Cancer_type QTL_type tag_SNP LD SNP SNP_position Alleles Methylation_probe Methylation_position Probe_related_gene Beta t-stat Correlation_coefficient (r) p-value Traits BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 14.31 0.49 1.76e-40 Alzheimer's disease; BRCA cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg13395646 chr4:1353034 KIAA1530 -0.52 -9.44 -0.35 6.79e-20 Obesity-related traits; BRCA cis rs72772090 0.539 rs2042386 chr5:96156783 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -12.03 -0.43 3.57e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4728302 0.869 rs889825 chr7:133596227 A/G cg07491979 chr7:133331646 EXOC4 0.36 7.84 0.3 1.88e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg24069376 chr3:38537580 EXOG -0.31 -8.76 -0.33 1.81e-17 Electrocardiographic conduction measures; BRCA cis rs4776059 1.000 rs12902679 chr15:52881317 C/T cg25063058 chr15:52860530 ARPP19 -0.37 -8.24 -0.31 9.45e-16 Schizophrenia; BRCA cis rs11758351 0.715 rs75390741 chr6:26209784 A/T cg01420254 chr6:26195488 NA 0.55 8.58 0.32 7.05e-17 Gout;Renal underexcretion gout; BRCA cis rs4466137 0.830 rs6886442 chr5:82973210 A/C cg15083037 chr5:83017644 HAPLN1 0.43 9.21 0.34 4.45e-19 Prostate cancer; BRCA cis rs2304069 1.000 rs10072275 chr5:149401596 T/C cg12661370 chr5:149340060 SLC26A2 0.51 7.81 0.3 2.44e-14 HIV-1 control; BRCA cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -9.2 -0.34 5.08e-19 Monocyte percentage of white cells; BRCA cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg17143192 chr8:8559678 CLDN23 0.57 11.15 0.4 1.68e-26 Obesity-related traits; BRCA cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg25801113 chr15:45476975 SHF -0.33 -8.06 -0.3 3.9e-15 Uric acid levels; BRCA cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg16850897 chr7:100343110 ZAN -0.57 -12.25 -0.44 3.72e-31 Other erythrocyte phenotypes; BRCA cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg01017244 chr2:74357527 NA 0.57 13.12 0.46 5.33e-35 Gestational age at birth (maternal effect); BRCA cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.47 0.35 5.16e-20 Tonsillectomy; BRCA cis rs870825 0.929 rs72689272 chr4:185592515 T/C cg04058563 chr4:185651563 MLF1IP 0.69 11.75 0.42 5.29e-29 Blood protein levels; BRCA cis rs7584330 0.704 rs72620821 chr2:238362615 C/A cg14458575 chr2:238380390 NA 0.74 16.58 0.55 1.26e-51 Prostate cancer; BRCA cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs858239 0.699 rs955187 chr7:23194605 A/G cg23682824 chr7:23144976 KLHL7 -0.4 -10.38 -0.38 2e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg11766577 chr21:47581405 C21orf56 -0.44 -9.82 -0.36 2.65e-21 Testicular germ cell tumor; BRCA cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4588572 0.644 rs1428864 chr5:77780263 C/T cg18281939 chr5:77783895 LHFPL2 0.33 8.0 0.3 5.99e-15 Triglycerides; BRCA cis rs79976124 0.837 rs74327235 chr6:66648353 T/A cg07460842 chr6:66804631 NA 0.6 10.31 0.38 3.63e-23 Type 2 diabetes; BRCA cis rs7537052 0.564 rs6669395 chr1:36653717 A/G cg24686825 chr1:36642396 MAP7D1 -0.54 -12.38 -0.44 1.07e-31 Schizophrenia; BRCA cis rs875971 0.545 rs313828 chr7:65552614 T/C cg11764359 chr7:65958608 NA -0.64 -11.28 -0.41 4.68e-27 Aortic root size; BRCA cis rs6669919 0.967 rs7513031 chr1:211671900 C/T cg10512769 chr1:211675356 NA 0.53 14.69 0.5 2.77e-42 Intelligence (multi-trait analysis); BRCA cis rs7399018 1.000 rs7399018 chr12:51610365 C/T cg25754956 chr12:51612065 POU6F1 -0.77 -15.88 -0.53 4.04e-48 Cisplatin-induced ototoxicity; BRCA cis rs36051895 0.559 rs12342390 chr9:5211297 G/A cg02405213 chr9:5042618 JAK2 -0.44 -8.5 -0.32 1.31e-16 Pediatric autoimmune diseases; BRCA cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.47 -10.51 -0.38 6.2e-24 Personality dimensions; BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 14.16 0.49 8.34e-40 Alzheimer's disease; BRCA cis rs250677 0.687 rs185155 chr5:148455893 T/C cg23229984 chr5:148520753 ABLIM3 0.37 9.08 0.34 1.33e-18 Breast cancer; BRCA cis rs4363385 0.818 rs436621 chr1:153005492 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -13.49 -0.47 1.17e-36 Cognitive function; BRCA cis rs6840360 0.571 rs11726892 chr4:152555106 A/G cg22705602 chr4:152727874 NA -0.34 -8.61 -0.32 5.47e-17 Intelligence (multi-trait analysis); BRCA cis rs6005807 0.719 rs12168765 chr22:29033308 G/C cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg19077165 chr18:44547161 KATNAL2 -0.4 -8.39 -0.31 3.23e-16 Educational attainment; BRCA trans rs6951245 1.000 rs79327308 chr7:1108141 A/C cg13565492 chr6:43139072 SRF -0.84 -11.44 -0.41 1.02e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs10911251 0.528 rs2333622 chr1:183075456 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.34e-58 Colorectal cancer; BRCA cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg13010199 chr12:38710504 ALG10B -0.36 -7.95 -0.3 8.19e-15 Morning vs. evening chronotype; BRCA cis rs2120243 0.874 rs2316708 chr3:157150299 G/A cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.5 0.35 3.97e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs2688608 0.839 rs2633310 chr10:75594050 G/T cg23231163 chr10:75533350 FUT11 0.31 7.86 0.3 1.68e-14 Inflammatory bowel disease; BRCA cis rs72781680 0.716 rs2712086 chr2:24004739 G/C cg08917208 chr2:24149416 ATAD2B 0.58 9.58 0.35 2.06e-20 Lymphocyte counts; BRCA cis rs4268898 0.552 rs11125444 chr2:24367205 G/T cg06627628 chr2:24431161 ITSN2 0.4 8.51 0.32 1.24e-16 Asthma; BRCA cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg24110177 chr3:50126178 RBM5 -0.44 -9.7 -0.36 7.29e-21 Intelligence (multi-trait analysis); BRCA trans rs75804782 0.641 rs11904390 chr2:239344663 T/A cg01134436 chr17:81009848 B3GNTL1 0.72 9.3 0.35 2.26e-19 Morning vs. evening chronotype;Chronotype; BRCA cis rs4819052 0.679 rs2838859 chr21:46684517 C/T cg11663144 chr21:46675770 NA -0.45 -10.68 -0.39 1.29e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs765787 0.530 rs1706830 chr15:45516229 G/A cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg09184832 chr6:79620586 NA -0.53 -11.69 -0.42 9.66e-29 Intelligence (multi-trait analysis); BRCA trans rs561341 1.000 rs757009 chr17:30243937 A/G cg27661571 chr11:113659931 NA -0.48 -8.35 -0.31 4.29e-16 Hip circumference adjusted for BMI; BRCA cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg13256891 chr4:100009986 ADH5 0.5 10.34 0.38 2.72e-23 Alcohol dependence; BRCA cis rs478304 0.900 rs502468 chr11:65525119 T/G cg08755490 chr11:65554678 OVOL1 0.55 11.5 0.41 5.88e-28 Acne (severe); BRCA trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg25517755 chr10:38738941 LOC399744 -0.37 -7.85 -0.3 1.81e-14 Corneal astigmatism; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg25036284 chr2:26402008 FAM59B 0.94 15.84 0.53 6.66e-48 Gut microbiome composition (summer); BRCA cis rs7523050 0.643 rs71655970 chr1:109403895 A/G cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg23888215 chr10:79422304 NA -0.55 -10.7 -0.39 1.07e-24 Bone mineral density; BRCA cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg12165864 chr7:66369176 NA -0.45 -10.15 -0.37 1.58e-22 Corneal structure; BRCA cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.94 0.4 1.2e-25 Rheumatoid arthritis; BRCA cis rs887829 0.569 rs6431628 chr2:234647478 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.17 -0.31 1.7e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg08807101 chr21:30365312 RNF160 -0.6 -15.0 -0.51 8.49e-44 Dental caries; BRCA cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 10.62 0.39 2.31e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17253792 0.822 rs74940664 chr14:56135065 A/G cg01858014 chr14:56050164 KTN1 -0.74 -9.16 -0.34 7.15e-19 Putamen volume; BRCA cis rs832540 0.512 rs33320 chr5:56206529 C/T cg24531977 chr5:56204891 C5orf35 -0.52 -10.54 -0.38 4.73e-24 Coronary artery disease; BRCA cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg03477792 chr4:77819574 ANKRD56 0.66 16.03 0.54 7.83e-49 Emphysema distribution in smoking; BRCA trans rs804280 0.560 rs10503426 chr8:11589383 A/C cg15556689 chr8:8085844 FLJ10661 0.4 9.78 0.36 3.71e-21 Myopia (pathological); BRCA cis rs735539 0.645 rs1052209 chr13:21216850 C/T cg04906043 chr13:21280425 IL17D -0.45 -9.05 -0.34 1.73e-18 Dental caries; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs7727544 0.594 rs10479000 chr5:131607402 T/C cg14196790 chr5:131705035 SLC22A5 0.43 11.14 0.4 1.91e-26 Blood metabolite levels; BRCA cis rs68170813 0.559 rs12538090 chr7:106974647 T/C cg02696742 chr7:106810147 HBP1 -0.55 -9.02 -0.34 2.24e-18 Coronary artery disease; BRCA cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg27478167 chr7:817139 HEATR2 0.52 10.16 0.37 1.4e-22 Cerebrospinal P-tau181p levels; BRCA cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg21132104 chr15:45694354 SPATA5L1 -0.63 -12.37 -0.44 1.11e-31 Homoarginine levels; BRCA cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg04450456 chr4:17643702 FAM184B 0.37 10.97 0.4 8.68e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg26149184 chr10:133730230 NA -0.4 -8.15 -0.31 1.9e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg10802521 chr3:52805072 NEK4 -0.33 -8.47 -0.32 1.64e-16 Bipolar disorder; BRCA cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg22467129 chr15:76604101 ETFA -0.41 -9.06 -0.34 1.63e-18 Blood metabolite levels; BRCA cis rs6456156 0.586 rs9459853 chr6:167465774 C/A cg07741184 chr6:167504864 NA 0.33 9.86 0.36 1.89e-21 Primary biliary cholangitis; BRCA cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg22117172 chr7:91764530 CYP51A1 0.23 7.84 0.3 1.88e-14 Breast cancer; BRCA cis rs735396 1.000 rs1169313 chr12:121442670 C/T cg02403541 chr12:121454288 C12orf43 -0.53 -10.23 -0.38 7.64e-23 N-glycan levels; BRCA cis rs2624839 0.630 rs2624841 chr3:50198415 C/T cg24110177 chr3:50126178 RBM5 -0.45 -11.46 -0.41 8.7e-28 Intelligence (multi-trait analysis); BRCA cis rs7927771 0.524 rs7929014 chr11:47776283 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs3768617 0.510 rs10911247 chr1:183076993 A/G ch.1.3577855R chr1:183094577 LAMC1 0.62 15.71 0.53 2.81e-47 Fuchs's corneal dystrophy; BRCA trans rs1005277 0.505 rs7099777 chr10:38183569 A/C cg17830980 chr10:43048298 ZNF37B 0.43 10.04 0.37 4.1e-22 Extrinsic epigenetic age acceleration; BRCA cis rs3733585 0.683 rs6449140 chr4:9936437 G/C cg00071950 chr4:10020882 SLC2A9 -0.54 -13.14 -0.46 4.24e-35 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 16.16 0.54 1.57e-49 Platelet count; BRCA cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.5 -11.23 -0.41 7.7e-27 Cognitive ability; BRCA cis rs3820928 0.874 rs6718057 chr2:227834349 T/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.43 -0.32 2.26e-16 Pulmonary function; BRCA cis rs6665290 0.594 rs17592479 chr1:227173892 T/A cg10327440 chr1:227177885 CDC42BPA -1.09 -37.71 -0.83 1.23e-164 Myeloid white cell count; BRCA cis rs13064411 0.696 rs6438159 chr3:113217341 T/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs61990749 0.597 rs2112136 chr14:78248952 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.65 9.87 0.36 1.73e-21 Fibroblast growth factor basic levels; BRCA cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.12e-23 Motion sickness; BRCA cis rs9463078 0.764 rs10948190 chr6:44942300 C/T cg25276700 chr6:44698697 NA -0.37 -8.74 -0.33 2.08e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.29 -0.31 6.51e-16 Total body bone mineral density; BRCA cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg26647111 chr11:31128758 NA -0.42 -9.6 -0.36 1.78e-20 Red blood cell count; BRCA trans rs3733585 0.699 rs7657340 chr4:9966772 A/T cg26043149 chr18:55253948 FECH -0.38 -8.35 -0.31 4.17e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg04586622 chr2:25135609 ADCY3 0.46 11.61 0.42 2.11e-28 Body mass index in non-asthmatics; BRCA trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg03929089 chr4:120376271 NA -0.7 -13.75 -0.48 7e-38 Coronary artery disease; BRCA cis rs7178424 0.875 rs12912208 chr15:62354570 A/G cg00456672 chr15:62358751 C2CD4A 0.34 8.03 0.3 4.77e-15 Height; BRCA cis rs11098499 0.644 rs34835603 chr4:120553428 C/T cg09307838 chr4:120376055 NA 0.6 12.42 0.44 7.18e-32 Corneal astigmatism; BRCA cis rs4588572 0.643 rs9293747 chr5:77705567 A/G cg11547950 chr5:77652471 NA -0.49 -8.88 -0.33 6.8e-18 Triglycerides; BRCA cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs12611088 0.600 rs2261316 chr19:44030998 A/G cg15012607 chr19:44012195 ETHE1 0.34 8.37 0.31 3.66e-16 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs34779708 0.931 rs11010132 chr10:35517265 C/G cg03585969 chr10:35415529 CREM 0.46 9.54 0.35 2.91e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.41 -0.32 2.58e-16 Monocyte percentage of white cells; BRCA cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg15352829 chr14:105391018 PLD4 -0.38 -12.39 -0.44 9.37e-32 Rheumatoid arthritis; BRCA cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg22875332 chr1:76189707 ACADM -0.65 -15.56 -0.52 1.67e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9399135 0.967 rs4142299 chr6:135377186 G/T cg24558204 chr6:135376177 HBS1L 0.45 12.35 0.44 1.45e-31 Red blood cell count; BRCA trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg11707556 chr5:10655725 ANKRD33B -0.39 -8.16 -0.31 1.78e-15 Coronary artery disease; BRCA cis rs67460515 0.563 rs4494975 chr3:160866768 C/T cg03342759 chr3:160939853 NMD3 -0.74 -15.16 -0.51 1.44e-44 Parkinson's disease; BRCA cis rs1003719 0.715 rs6579 chr21:38568308 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.5 -0.5 2.11e-41 Eye color traits; BRCA cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg17644776 chr2:200775616 C2orf69 0.43 8.12 0.31 2.44e-15 Schizophrenia; BRCA trans rs1493916 0.967 rs9953768 chr18:31399468 A/G cg27147174 chr7:100797783 AP1S1 -0.54 -10.84 -0.39 2.87e-25 Life satisfaction; BRCA cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg19077165 chr18:44547161 KATNAL2 -0.37 -7.84 -0.3 1.9e-14 Educational attainment; BRCA cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -10.25 -0.38 6.1e-23 Reticulocyte count; BRCA cis rs9287719 0.967 rs10929686 chr2:10743705 A/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg03929089 chr4:120376271 NA -0.52 -10.22 -0.37 7.93e-23 HDL cholesterol; BRCA trans rs9291683 0.609 rs7678012 chr4:9993772 T/C cg26043149 chr18:55253948 FECH 0.4 8.92 0.33 5.05e-18 Bone mineral density; BRCA cis rs637571 0.522 rs491973 chr11:65727301 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.6 13.31 0.47 7.59e-36 Eosinophil percentage of white cells; BRCA cis rs10883723 0.810 rs7090276 chr10:104281239 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.08 0.62 6.44e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7584330 0.704 rs7598954 chr2:238364776 C/T cg14458575 chr2:238380390 NA 0.74 16.58 0.55 1.26e-51 Prostate cancer; BRCA cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg13298116 chr11:62369859 EML3;MTA2 0.58 13.53 0.47 7.75e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.4 0.57 8.98e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs6545883 0.929 rs2593627 chr2:61618574 T/C cg15711740 chr2:61764176 XPO1 0.53 13.63 0.47 2.48e-37 Tuberculosis; BRCA cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg13256891 chr4:100009986 ADH5 0.52 9.67 0.36 1e-20 Alcohol dependence; BRCA cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.61 -0.45 9.81e-33 Bipolar disorder; BRCA cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg06221963 chr1:154839813 KCNN3 -0.56 -16.1 -0.54 3.26e-49 Prostate cancer; BRCA cis rs2806561 0.929 rs2903545 chr1:23541108 C/T cg12483005 chr1:23474871 LUZP1 -0.37 -8.1 -0.31 2.77e-15 Height; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg18402987 chr7:1209562 NA 0.59 12.21 0.43 5.92e-31 Longevity;Endometriosis; BRCA cis rs9473147 0.516 rs10456570 chr6:47559451 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.62 0.36 1.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs3768617 0.510 rs10797852 chr1:183101302 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 17.73 0.57 1.72e-57 Fuchs's corneal dystrophy; BRCA cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.72e-15 Extrinsic epigenetic age acceleration; BRCA cis rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05901451 chr6:126070800 HEY2 0.4 9.85 0.36 2.14e-21 Endometrial cancer; BRCA cis rs66782572 1 rs66782572 chr3:52567617 A/G cg05564831 chr3:52568323 NT5DC2 0.35 8.38 0.31 3.49e-16 Hemoglobin concentration; BRCA cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg07636037 chr3:49044803 WDR6 0.94 27.29 0.73 2.81e-109 Parkinson's disease; BRCA cis rs2016266 0.820 rs11170496 chr12:53666195 G/A cg26875137 chr12:53738046 NA 0.37 9.85 0.36 2.16e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs867371 1.000 rs8037224 chr15:82464530 G/A cg00614314 chr15:82944287 LOC80154 0.43 9.07 0.34 1.5e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA trans rs1325195 0.920 rs2816209 chr1:179171494 A/G cg11624085 chr17:8464688 MYH10 0.27 7.83 0.3 2.09e-14 IgE grass sensitization; BRCA cis rs4803468 0.967 rs13345590 chr19:41886455 T/G cg09537434 chr19:41945824 ATP5SL -0.95 -22.68 -0.67 5.57e-84 Height; BRCA cis rs2204008 0.654 rs1733410 chr12:38132172 G/A cg26384229 chr12:38710491 ALG10B -0.46 -10.56 -0.39 3.73e-24 Bladder cancer; BRCA cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg00071950 chr4:10020882 SLC2A9 0.57 14.08 0.49 2.16e-39 Bone mineral density; BRCA cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.5 0.5 2.04e-41 Colorectal cancer; BRCA cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg23029597 chr12:123009494 RSRC2 -0.56 -10.93 -0.4 1.27e-25 Body mass index; BRCA cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg01028140 chr2:1542097 TPO -0.57 -11.98 -0.43 5.46e-30 IgG glycosylation; BRCA cis rs9297145 0.958 rs11975761 chr7:98766688 G/A cg05967295 chr7:98741636 SMURF1 -0.86 -20.46 -0.63 6.31e-72 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg11764359 chr7:65958608 NA -0.64 -13.57 -0.47 5e-37 Aortic root size; BRCA cis rs7833986 0.501 rs2953911 chr8:56948009 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.47 7.89 0.3 1.28e-14 Height; BRCA cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg21573476 chr21:45109991 RRP1B -0.37 -9.43 -0.35 7.44e-20 Mean corpuscular volume; BRCA cis rs1941023 0.503 rs4939349 chr11:60135880 G/A cg08716584 chr11:60157161 MS4A7 -0.44 -10.11 -0.37 2.2e-22 Congenital heart disease (maternal effect); BRCA cis rs36051895 0.659 rs7859390 chr9:5062473 A/T cg02405213 chr9:5042618 JAK2 -0.46 -8.53 -0.32 1.1e-16 Pediatric autoimmune diseases; BRCA cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg25427524 chr10:38739819 LOC399744 -0.73 -17.56 -0.57 1.24e-56 Extrinsic epigenetic age acceleration; BRCA cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg10128416 chr1:75198403 TYW3;CRYZ -0.45 -9.23 -0.34 4.01e-19 Resistin levels; BRCA cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg21724239 chr8:58056113 NA 0.46 8.08 0.3 3.13e-15 Developmental language disorder (linguistic errors); BRCA cis rs4908760 0.965 rs1884352 chr1:8537289 G/A cg20416874 chr1:8611966 RERE -0.28 -7.97 -0.3 7.1e-15 Vitiligo; BRCA cis rs73086581 1.000 rs73086595 chr20:3983448 A/G cg02187196 chr20:3869020 PANK2 0.53 9.37 0.35 1.23e-19 Response to antidepressants in depression; BRCA cis rs9287719 0.967 rs1541574 chr2:10773508 A/T cg02196655 chr2:10830764 NOL10 -0.3 -7.92 -0.3 1.04e-14 Prostate cancer; BRCA cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg17524180 chr13:113633600 MCF2L -0.31 -7.91 -0.3 1.13e-14 Systolic blood pressure; BRCA cis rs7727544 0.660 rs274563 chr5:131717859 C/A cg07395648 chr5:131743802 NA 0.4 9.97 0.37 7.52e-22 Blood metabolite levels; BRCA cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg16109817 chr1:16162209 FLJ37453 0.29 8.23 0.31 1.09e-15 Systolic blood pressure; BRCA cis rs10193935 0.901 rs222479 chr2:42656857 T/G cg27598129 chr2:42591480 NA -0.78 -13.27 -0.46 1.12e-35 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg27446573 chr6:127587934 RNF146 0.9 21.31 0.64 1.56e-76 Breast cancer; BRCA cis rs112217694 1.000 rs17196218 chr4:104658371 C/T cg17160751 chr4:104641250 TACR3 -0.78 -8.34 -0.31 4.52e-16 Menarche (age at onset); BRCA cis rs7246657 0.943 rs4969487 chr19:37831039 C/T cg18154014 chr19:37997991 ZNF793 0.61 11.43 0.41 1.22e-27 Coronary artery calcification; BRCA cis rs11585357 0.895 rs72633806 chr1:17617943 A/G cg08277548 chr1:17600880 PADI3 -0.76 -12.36 -0.44 1.32e-31 Hair shape; BRCA cis rs509477 0.962 rs562412 chr18:32576305 T/C cg00449728 chr18:32561817 MAPRE2 -0.34 -7.84 -0.3 1.92e-14 Cerebrospinal fluid AB1-42 levels; BRCA cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg22862634 chr11:62369728 EML3;MTA2 0.57 13.82 0.48 3.38e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11719291 0.833 rs11709246 chr3:48859498 G/A cg00383909 chr3:49044727 WDR6 0.96 15.69 0.53 3.76e-47 Cognitive function; BRCA cis rs8062405 0.737 rs11861132 chr16:28871860 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg20476274 chr7:133979776 SLC35B4 0.67 20.05 0.62 9.59e-70 Mean platelet volume; BRCA trans rs208520 0.690 rs207077 chr6:66769855 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.94 -0.64 1.57e-74 Exhaled nitric oxide output; BRCA cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg26384229 chr12:38710491 ALG10B 0.76 16.95 0.56 1.79e-53 Bladder cancer; BRCA cis rs11190604 0.767 rs10883479 chr10:102162860 A/G cg07080220 chr10:102295463 HIF1AN 0.5 10.59 0.39 3.07e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg19318889 chr4:1322082 MAEA -0.6 -11.97 -0.43 6.25e-30 Longevity; BRCA cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.05e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg27478167 chr7:817139 HEATR2 -0.42 -9.1 -0.34 1.12e-18 Cerebrospinal P-tau181p levels; BRCA cis rs9814567 1.000 rs4974484 chr3:134219019 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.44 -0.32 2.09e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg11764359 chr7:65958608 NA -0.76 -17.53 -0.57 1.89e-56 Aortic root size; BRCA cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.5 0.35 4.14e-20 Motion sickness; BRCA cis rs6835098 0.961 rs11737748 chr4:174130503 T/C cg08422745 chr4:174089978 GALNT7 0.81 15.25 0.52 5.13e-45 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs694739 0.628 rs538147 chr11:64129722 G/A cg23796481 chr11:64053134 BAD;GPR137 0.5 10.45 0.38 1.1e-23 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs7394190 0.748 rs4746151 chr10:75578720 G/T cg07699608 chr10:75541558 CHCHD1 0.68 9.91 0.36 1.24e-21 Incident atrial fibrillation; BRCA cis rs11051970 0.679 rs2651366 chr12:32560431 T/C cg02745156 chr12:32552066 NA 0.25 8.31 0.31 5.6e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg20503657 chr10:835505 NA 0.9 16.21 0.54 9.35e-50 Eosinophil percentage of granulocytes; BRCA cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs9790314 1.000 rs459697 chr3:161093420 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.3 -0.49 1.95e-40 Morning vs. evening chronotype; BRCA cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg23583168 chr7:148888333 NA -0.85 -19.73 -0.62 4.99e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs9329221 0.527 rs6989657 chr8:10330873 C/G cg15556689 chr8:8085844 FLJ10661 0.35 8.92 0.33 4.87e-18 Neuroticism; BRCA cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg18876405 chr7:65276391 NA -0.66 -16.81 -0.55 9.26e-53 Aortic root size; BRCA cis rs2625529 0.824 rs12593134 chr15:72303007 G/C cg16672083 chr15:72433130 SENP8 -0.85 -17.68 -0.57 3.22e-57 Red blood cell count; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg22920501 chr2:26401640 FAM59B -0.95 -17.06 -0.56 4.64e-54 Gut microbiome composition (summer); BRCA cis rs910316 1.000 rs13099 chr14:75599155 G/A cg08847533 chr14:75593920 NEK9 -0.86 -22.01 -0.66 2.57e-80 Height; BRCA cis rs11105298 0.838 rs10858862 chr12:89842053 T/C cg00757033 chr12:89920650 WDR51B 0.53 10.69 0.39 1.16e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs1962073 0.528 rs9329223 chr8:10331754 C/T cg06636001 chr8:8085503 FLJ10661 -0.42 -8.76 -0.33 1.78e-17 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); BRCA cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.49 0.41 6.35e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs800082 0.698 rs800070 chr3:144346614 A/T cg24215973 chr2:240111563 HDAC4 -0.61 -14.69 -0.5 2.54e-42 Smoking behavior; BRCA cis rs7927771 0.965 rs12787112 chr11:47687147 A/G cg18512352 chr11:47633146 NA -0.35 -8.52 -0.32 1.17e-16 Subjective well-being; BRCA cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg01528321 chr10:82214614 TSPAN14 0.62 14.01 0.48 4.46e-39 Post bronchodilator FEV1; BRCA cis rs9467773 0.620 rs2504599 chr6:26641060 C/T cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.76e-30 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 8.85e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6459804 1.000 rs6459805 chr7:157510294 T/C cg05731713 chr7:157510257 PTPRN2 0.41 10.58 0.39 3.25e-24 Bipolar disorder and schizophrenia; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg09436375 chr6:42928200 GNMT -0.28 -10.58 -0.39 3.38e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11890956 chr21:40555474 PSMG1 -0.81 -19.19 -0.6 3.68e-65 Cognitive function; BRCA cis rs1577917 0.560 rs9450288 chr6:86221586 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.36 9.94 0.37 9.9700000000000009e-22 Response to antipsychotic treatment; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg22907277 chr7:1156413 C7orf50 0.59 9.18 0.34 5.82e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg12463550 chr7:65579703 CRCP -0.36 -7.83 -0.3 2.02e-14 Aortic root size; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.74 -0.33 2.1e-17 Total body bone mineral density; BRCA cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg23649088 chr2:200775458 C2orf69 -0.58 -8.59 -0.32 6.42e-17 Schizophrenia; BRCA cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg02466173 chr16:30829666 NA -0.5 -11.4 -0.41 1.52e-27 Dementia with Lewy bodies; BRCA cis rs11734570 0.581 rs4461531 chr4:38603576 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.51 9.49 0.35 4.41e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.47 -11.22 -0.41 8.22e-27 IgG glycosylation; BRCA cis rs6495367 1.000 rs755362 chr15:79376601 C/T cg17916960 chr15:79447300 NA -0.33 -8.4 -0.32 2.78e-16 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs3733585 0.578 rs4466042 chr4:9955367 T/C cg26043149 chr18:55253948 FECH -0.37 -8.3 -0.31 6.41e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17021463 0.902 rs2016483 chr4:95229039 A/T cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.03 -0.37 4.4e-22 Testicular germ cell tumor; BRCA cis rs11585357 0.947 rs72646789 chr1:17610030 C/T cg19159961 chr1:17633534 PADI4 0.58 9.22 0.34 4.14e-19 Hair shape; BRCA cis rs61931739 0.500 rs7489130 chr12:34539674 C/A cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs595982 0.559 rs17206714 chr19:49362001 T/A cg21252483 chr19:49399788 TULP2 -0.43 -9.38 -0.35 1.09e-19 Red cell distribution width; BRCA cis rs13046373 0.507 rs11088139 chr21:31978884 T/G cg16812893 chr21:31813075 KRTAP15-1 0.39 9.84 0.36 2.21e-21 HDL cholesterol; BRCA trans rs6479891 0.915 rs9415682 chr10:65033817 G/T cg14819942 chr15:35414228 NA -0.35 -8.57 -0.32 7.85e-17 Arthritis (juvenile idiopathic); BRCA cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg14582100 chr15:45693742 SPATA5L1 -0.33 -10.41 -0.38 1.45e-23 Homoarginine levels; BRCA cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg03717367 chr9:139980219 LOC100289341;MAN1B1 0.38 8.97 0.33 3.38e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg13010199 chr12:38710504 ALG10B 0.5 9.89 0.36 1.54e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg20090143 chr19:45452003 APOC2 0.27 7.89 0.3 1.31e-14 Blood protein levels; BRCA cis rs2795502 1.000 rs3121278 chr10:43375646 G/T cg20628663 chr10:43360327 NA 0.65 12.79 0.45 1.61e-33 Blood protein levels; BRCA cis rs7395581 0.798 rs10769252 chr11:47343955 A/G cg25783544 chr11:47291846 MADD 0.42 9.52 0.35 3.48e-20 HDL cholesterol; BRCA cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22509189 chr2:225307070 NA -0.46 -9.94 -0.37 1e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs10751667 0.666 rs11246358 chr11:967349 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.8 0.53 9.98e-48 Alzheimer's disease (late onset); BRCA cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg26248373 chr2:1572462 NA -0.56 -12.8 -0.45 1.44e-33 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg16339924 chr4:17578868 LAP3 0.62 15.42 0.52 7.56e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs59918340 0.764 rs4961338 chr8:142230192 C/T cg23750338 chr8:142222470 SLC45A4 -0.52 -12.67 -0.45 5.34e-33 Immature fraction of reticulocytes; BRCA trans rs1459104 1.000 rs36082455 chr11:55271813 A/G cg15704280 chr7:45808275 SEPT13 0.65 8.14 0.31 2.12e-15 Body mass index; BRCA cis rs7582180 0.739 rs11123824 chr2:100924029 G/A cg14675211 chr2:100938903 LONRF2 0.49 11.2 0.4 1.09e-26 Intelligence (multi-trait analysis); BRCA cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg26031613 chr14:104095156 KLC1 0.7 15.03 0.51 6.13e-44 Body mass index; BRCA cis rs10492096 0.947 rs11064231 chr12:6604415 T/G cg13857086 chr12:6580257 VAMP1 0.43 8.41 0.32 2.66e-16 Hip geometry; BRCA cis rs6942756 1.000 rs6467235 chr7:128939150 A/G cg02491457 chr7:128862824 NA 0.69 12.73 0.45 3.08e-33 White matter hyperintensity burden; BRCA cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg22800045 chr5:56110881 MAP3K1 0.66 12.38 0.44 1.06e-31 Initial pursuit acceleration; BRCA cis rs62229266 0.804 rs2835259 chr21:37425302 T/C cg12218747 chr21:37451666 NA -0.33 -7.91 -0.3 1.11e-14 Mitral valve prolapse; BRCA cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg04117972 chr1:227635322 NA 0.49 8.91 0.33 5.31e-18 Major depressive disorder; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg09177884 chr7:1199841 ZFAND2A -0.59 -14.35 -0.49 1.12e-40 Longevity;Endometriosis; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.88 -0.3 1.4e-14 Total body bone mineral density; BRCA cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 13.0 0.46 1.8e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11711311 1.000 rs2305546 chr3:113503354 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.77 -0.39 5.8e-25 IgG glycosylation; BRCA cis rs9399135 0.838 rs4896126 chr6:135342786 C/A cg24558204 chr6:135376177 HBS1L 0.44 12.2 0.43 6.19e-31 Red blood cell count; BRCA cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg08917208 chr2:24149416 ATAD2B 1.1 15.84 0.53 6.79e-48 Lymphocyte counts; BRCA cis rs2762353 0.904 rs13197514 chr6:25785991 C/T cg12310025 chr6:25882481 NA 0.52 12.44 0.44 5.51e-32 Blood metabolite levels; BRCA cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg27286337 chr10:134555280 INPP5A 0.61 11.91 0.43 1.14e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs17401966 0.964 rs34215045 chr1:10361679 G/A cg15208524 chr1:10270712 KIF1B 0.38 8.21 0.31 1.21e-15 Hepatocellular carcinoma; BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg12564285 chr5:131593104 PDLIM4 0.38 10.19 0.37 1.08e-22 Breast cancer; BRCA cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.722 rs2909098 chr19:38204248 G/A cg18154014 chr19:37997991 ZNF793 -0.51 -9.66 -0.36 1.05e-20 Coronary artery calcification; BRCA cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02475777 chr4:1388615 CRIPAK 0.66 12.88 0.45 6.35e-34 Longevity; BRCA cis rs1775715 0.707 rs2808079 chr10:32167385 C/T cg14930904 chr10:32216787 ARHGAP12 0.34 7.88 0.3 1.4e-14 Bipolar disorder with mood-incongruent psychosis; BRCA trans rs9784649 0.641 rs72755823 chr5:25075537 T/C cg08600765 chr20:34638493 LOC647979 -0.76 -12.32 -0.44 1.87e-31 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg03188948 chr7:1209495 NA 0.73 11.99 0.43 4.92e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7937890 1.000 rs2970335 chr11:14325401 A/C cg19336497 chr11:14380999 RRAS2 -0.3 -8.08 -0.3 3.3e-15 Mitochondrial DNA levels; BRCA trans rs1547374 0.737 rs178741 chr21:43779408 G/A cg09521743 chr10:75415752 SYNPO2L 0.42 8.47 0.32 1.7e-16 Pancreatic cancer; BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -14.37 -0.49 8.94e-41 Type 2 diabetes; BRCA cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.92 -0.33 4.73e-18 Lobe attachment (rater-scored or self-reported); BRCA trans rs208520 0.690 rs7764570 chr6:66827600 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -19.18 -0.6 4.01e-65 Exhaled nitric oxide output; BRCA cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg11812906 chr14:75593930 NEK9 0.59 13.65 0.48 2.04e-37 Height; BRCA cis rs6866344 0.697 rs56159071 chr5:178127246 T/A cg10224037 chr5:178157518 ZNF354A 0.76 15.88 0.53 4.32e-48 Neutrophil percentage of white cells; BRCA cis rs17253792 0.822 rs77990307 chr14:56070049 T/C cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.78 -0.36 3.73e-21 Tonsillectomy; BRCA cis rs2204008 0.540 rs3908193 chr12:38410907 G/T cg26384229 chr12:38710491 ALG10B -0.43 -9.99 -0.37 6.12e-22 Bladder cancer; BRCA cis rs10870270 0.957 rs10870307 chr10:133780610 T/C cg08754478 chr10:133766260 PPP2R2D -0.68 -13.9 -0.48 1.42e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6669919 0.565 rs10863911 chr1:211686860 C/T cg10512769 chr1:211675356 NA -0.4 -10.64 -0.39 1.94e-24 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg20607798 chr8:58055168 NA 0.51 10.9 0.4 1.7e-25 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.63e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2658782 0.724 rs2605627 chr11:93259515 A/G cg15737290 chr11:93063684 CCDC67 0.49 9.56 0.35 2.4e-20 Pulmonary function decline; BRCA cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg00339695 chr16:24857497 SLC5A11 0.51 11.21 0.41 9.46e-27 Intelligence (multi-trait analysis); BRCA cis rs2835872 0.758 rs1709820 chr21:39035971 A/C cg06728970 chr21:39037746 KCNJ6 0.44 12.59 0.45 1.22e-32 Electroencephalographic traits in alcoholism; BRCA trans rs11098499 0.826 rs4472123 chr4:120236630 T/A cg25214090 chr10:38739885 LOC399744 0.46 10.46 0.38 9.42e-24 Corneal astigmatism; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg07308232 chr7:1071921 C7orf50 -0.4 -8.79 -0.33 1.33e-17 Longevity;Endometriosis; BRCA cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg11366901 chr6:160182831 ACAT2 0.78 15.29 0.52 3.18e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs9814567 0.806 rs1880374 chr3:134322113 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs2204008 0.577 rs11520050 chr12:38051839 G/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 7.99e-21 Bladder cancer; BRCA cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg05707623 chr12:122985044 ZCCHC8 -0.45 -8.71 -0.33 2.5e-17 Body mass index; BRCA trans rs629535 0.821 rs497398 chr8:70037434 A/T cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs6763687 0.693 rs1353894 chr3:171807514 G/A cg16233210 chr3:171778391 FNDC3B 0.38 9.09 0.34 1.24e-18 Red cell distribution width; BRCA cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg11764359 chr7:65958608 NA -0.78 -18.53 -0.59 1.09e-61 Aortic root size; BRCA cis rs6840360 0.615 rs7669465 chr4:152609289 C/T cg22705602 chr4:152727874 NA -0.37 -9.89 -0.36 1.43e-21 Intelligence (multi-trait analysis); BRCA cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg14784868 chr12:69753453 YEATS4 0.51 12.47 0.44 4.34e-32 Blood protein levels; BRCA trans rs1912785 1.000 rs4681123 chr3:146405343 C/T cg18433293 chr15:41576837 LOC729082 -0.26 -8.23 -0.31 1.06e-15 Barrett's esophagus; BRCA cis rs7766436 0.767 rs11754964 chr6:22604737 G/T cg13666174 chr6:22585274 NA -0.37 -9.5 -0.35 4.04e-20 Coronary artery disease; BRCA cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg15017067 chr4:17643749 FAM184B 0.28 8.47 0.32 1.64e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs34779708 0.931 rs7923172 chr10:35309367 G/A cg03585969 chr10:35415529 CREM 0.49 10.3 0.38 3.94e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg20887711 chr4:1340912 KIAA1530 -0.73 -15.53 -0.52 2.14e-46 Longevity; BRCA cis rs17253792 0.822 rs74051609 chr14:56171132 G/A cg01858014 chr14:56050164 KTN1 -0.57 -8.78 -0.33 1.47e-17 Putamen volume; BRCA trans rs8073060 0.586 rs72829927 chr17:34049992 A/G cg19694781 chr19:47549865 TMEM160 1.07 20.64 0.63 6.34e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs6598955 0.671 rs7551557 chr1:26596614 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.62 -13.07 -0.46 9e-35 Obesity-related traits; BRCA cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg26446133 chr18:72167187 CNDP2 -0.79 -19.95 -0.62 3.3e-69 Refractive error; BRCA cis rs2712431 0.554 rs9864772 chr3:128316939 A/G cg16766828 chr3:128327626 NA -0.36 -8.2 -0.31 1.29e-15 Monocyte chemoattractant protein-1 levels; BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg22638593 chr5:131593259 PDLIM4 0.31 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg05793240 chr7:2802953 GNA12 -0.32 -8.81 -0.33 1.17e-17 Height; BRCA cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.01 0.3 5.31e-15 Breast cancer; BRCA trans rs11722228 0.508 rs3796825 chr4:10092879 T/A cg26043149 chr18:55253948 FECH 1.09 23.21 0.68 7.07e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs4808199 0.895 rs10403731 chr19:19469296 G/A cg03709012 chr19:19516395 GATAD2A 0.91 17.4 0.57 8.79e-56 Nonalcoholic fatty liver disease; BRCA cis rs6456156 1.000 rs9457274 chr6:167520865 G/T cg07741184 chr6:167504864 NA 0.28 8.54 0.32 9.83e-17 Primary biliary cholangitis; BRCA cis rs73086581 1.000 rs6037708 chr20:3961253 C/G cg02187196 chr20:3869020 PANK2 0.46 8.29 0.31 6.69e-16 Response to antidepressants in depression; BRCA trans rs11098499 0.774 rs11098505 chr4:120284627 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.37 8.02 0.3 4.99e-15 Schizophrenia; BRCA cis rs6973256 0.865 rs10954424 chr7:133335479 G/A cg07491979 chr7:133331646 EXOC4 -0.39 -8.91 -0.33 5.11e-18 Intelligence (multi-trait analysis); BRCA cis rs7247513 0.866 rs2861405 chr19:12722332 A/C cg01871581 chr19:12707946 ZNF490 -0.68 -15.15 -0.51 1.56e-44 Bipolar disorder; BRCA cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs11577318 0.796 rs4625269 chr1:26626967 C/A cg07461501 chr17:79650226 HGS;ARL16 0.39 10.0 0.37 5.83e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6121246 0.559 rs6087779 chr20:30370566 T/C cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA cis rs4911259 0.513 rs4287835 chr20:31457337 T/C cg13636640 chr20:31349939 DNMT3B -0.44 -11.55 -0.42 3.8e-28 Inflammatory bowel disease; BRCA cis rs6430585 0.527 rs1446586 chr2:136407445 C/T cg07169764 chr2:136633963 MCM6 -0.99 -19.44 -0.61 1.81e-66 Corneal structure; BRCA cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg22875332 chr1:76189707 ACADM 0.52 9.91 0.37 1.21e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3824867 0.920 rs3740684 chr11:47468820 C/T cg20307385 chr11:47447363 PSMC3 0.51 11.35 0.41 2.59e-27 Mean corpuscular hemoglobin; BRCA cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg01262667 chr19:19385393 TM6SF2 0.34 8.76 0.33 1.71e-17 Tonsillectomy; BRCA cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg21573476 chr21:45109991 RRP1B -0.36 -9.23 -0.34 3.85e-19 Mean corpuscular volume; BRCA cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.09 0.4 2.94e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg23285459 chr7:2802560 GNA12 -0.36 -8.95 -0.33 3.74e-18 Height; BRCA cis rs7512552 0.839 rs1097070 chr1:150332955 A/T cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.81e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs11191270 1.000 rs4919624 chr10:104021085 A/G cg15320455 chr10:103880129 LDB1 0.53 8.74 0.33 1.97e-17 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg20701182 chr2:24300061 SF3B14 0.62 8.83 0.33 9.71e-18 Lymphocyte counts; BRCA cis rs6580649 1.000 rs7132668 chr12:48405860 C/T cg05342945 chr12:48394962 COL2A1 -0.43 -8.35 -0.31 4.37e-16 Lung cancer; BRCA cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg20701182 chr2:24300061 SF3B14 0.57 8.72 0.33 2.31e-17 Lymphocyte counts; BRCA cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg06634786 chr22:41940651 POLR3H -0.52 -9.56 -0.35 2.54e-20 Vitiligo; BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg21724239 chr8:58056113 NA -0.58 -9.33 -0.35 1.66e-19 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg06618935 chr21:46677482 NA -0.39 -8.63 -0.32 4.85e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6598955 0.572 rs6598951 chr1:26592714 G/T cg04990556 chr1:26633338 UBXN11 0.54 8.89 0.33 6.19e-18 Obesity-related traits; BRCA cis rs11676348 0.846 rs11677534 chr2:219007060 T/C cg00012203 chr2:219082015 ARPC2 -0.42 -8.23 -0.31 1.08e-15 Ulcerative colitis; BRCA cis rs1538970 0.851 rs61788285 chr1:45919234 A/C cg05343316 chr1:45956843 TESK2 0.65 13.23 0.46 1.66e-35 Platelet count; BRCA cis rs911119 0.913 rs6036465 chr20:23588003 G/T cg16589663 chr20:23618590 CST3 0.39 7.99 0.3 6.43e-15 Chronic kidney disease; BRCA cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg02018176 chr4:1364513 KIAA1530 0.36 7.94 0.3 9.15e-15 Longevity; BRCA cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.15 0.31 1.95e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7020830 0.931 rs1388978 chr9:37144062 G/T cg14294708 chr9:37120828 ZCCHC7 1.05 31.36 0.78 2.06e-131 Schizophrenia; BRCA cis rs10771431 0.597 rs7976807 chr12:9352459 G/A cg08997352 chr12:9597637 DDX12 -0.54 -10.16 -0.37 1.42e-22 Breast size; BRCA cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.39 8.33 0.31 5.04e-16 Osteoporosis; BRCA cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg03060546 chr3:49711283 APEH 0.6 9.83 0.36 2.5e-21 Menarche (age at onset); BRCA cis rs7737355 0.898 rs4706024 chr5:130904163 G/A cg06307176 chr5:131281290 NA 0.54 10.74 0.39 7.2e-25 Life satisfaction; BRCA cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.02 0.37 4.95e-22 Bipolar disorder; BRCA cis rs4481887 0.927 rs28524655 chr1:248474331 C/T cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg12379764 chr21:47803548 PCNT -0.4 -8.98 -0.33 2.9e-18 Testicular germ cell tumor; BRCA cis rs4642101 0.824 rs11717013 chr3:12843862 A/C cg24848339 chr3:12840334 CAND2 0.41 10.6 0.39 2.8e-24 QRS complex (12-leadsum); BRCA cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA trans rs9409565 0.855 rs7042481 chr9:97064273 C/A cg05679027 chr9:99775184 HIATL2 0.41 9.08 0.34 1.33e-18 Colorectal cancer (alcohol consumption interaction); BRCA cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg21535247 chr6:8435926 SLC35B3 0.39 8.87 0.33 7.22e-18 Motion sickness; BRCA cis rs2777491 0.957 rs16971798 chr15:41657144 A/T cg18705301 chr15:41695430 NDUFAF1 0.6 13.85 0.48 2.34e-38 Ulcerative colitis; BRCA cis rs6952809 0.532 rs6952152 chr7:2440912 G/A cg05083358 chr7:2394359 EIF3B -0.51 -8.04 -0.3 4.52e-15 Multiple sclerosis; BRCA trans rs8073060 0.516 rs2376177 chr17:33938089 T/G cg19694781 chr19:47549865 TMEM160 -1.04 -21.61 -0.65 3.85e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1865721 1.000 rs62089511 chr18:73197629 C/T cg26385618 chr18:73139727 C18orf62 -0.38 -8.66 -0.32 3.85e-17 Intelligence; BRCA cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.74 10.05 0.37 3.52e-22 Initial pursuit acceleration; BRCA trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg26384229 chr12:38710491 ALG10B 0.57 13.37 0.47 4.08e-36 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg15485101 chr11:133734466 NA 0.4 9.74 0.36 5.55e-21 Childhood ear infection; BRCA cis rs11098499 0.739 rs4833612 chr4:120147596 A/C cg09307838 chr4:120376055 NA -0.49 -9.27 -0.34 2.75e-19 Corneal astigmatism; BRCA cis rs716316 1.000 rs716316 chr20:14908741 C/T cg04470754 chr20:14904432 MACROD2 0.44 10.54 0.38 4.57e-24 Advanced glycation end-product levels; BRCA cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg24829409 chr8:58192753 C8orf71 -0.58 -12.18 -0.43 8.01e-31 Developmental language disorder (linguistic errors); BRCA cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg13852791 chr20:30311386 BCL2L1 0.86 16.78 0.55 1.31e-52 Mean corpuscular hemoglobin; BRCA cis rs2282802 0.685 rs67813630 chr5:139623592 C/A cg26211634 chr5:139558579 C5orf32 0.36 8.45 0.32 2.04e-16 Intelligence (multi-trait analysis); BRCA trans rs8073060 0.586 rs226090 chr17:34034059 C/T cg19694781 chr19:47549865 TMEM160 -1.07 -20.59 -0.63 1.26e-72 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2712184 0.756 rs2024487 chr2:217663271 C/T cg05032264 chr2:217675019 NA 0.35 8.61 0.32 5.6e-17 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs9517320 0.534 rs4772088 chr13:99138270 T/G cg20487152 chr13:99095054 FARP1 -0.33 -7.96 -0.3 7.85e-15 Longevity; BRCA trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg13010199 chr12:38710504 ALG10B -0.5 -9.77 -0.36 4.33e-21 Morning vs. evening chronotype; BRCA cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg18270830 chr10:32634957 EPC1 0.6 10.44 0.38 1.1e-23 Sexual dysfunction (female); BRCA cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.41 0.38 1.45e-23 Bladder cancer; BRCA cis rs1942 0.837 rs12440045 chr15:41782684 A/C cg18705301 chr15:41695430 NDUFAF1 -0.46 -9.08 -0.34 1.38e-18 Eosinophil percentage of granulocytes; BRCA cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg00745463 chr17:30367425 LRRC37B -0.62 -9.94 -0.37 9.63e-22 Hip circumference adjusted for BMI; BRCA cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg04450456 chr4:17643702 FAM184B 0.37 10.81 0.39 4.03e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg25206134 chr2:45395956 NA 0.52 8.73 0.33 2.2e-17 Bipolar disorder; BRCA cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg08754478 chr10:133766260 PPP2R2D -0.67 -13.02 -0.46 1.47e-34 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6752107 0.503 rs12997325 chr2:234237387 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.38 7.84 0.3 1.84e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs495337 0.736 rs530461 chr20:48467716 A/G cg17835207 chr20:48524531 SPATA2 0.53 12.06 0.43 2.56e-30 Psoriasis; BRCA cis rs593982 0.920 rs618456 chr11:65475620 C/T cg08755490 chr11:65554678 OVOL1 1.18 17.51 0.57 2.18e-56 Atopic dermatitis; BRCA trans rs330048 0.545 rs11249913 chr8:9143521 G/T cg08975724 chr8:8085496 FLJ10661 -0.49 -10.26 -0.38 5.69e-23 Systemic lupus erythematosus; BRCA cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg08000102 chr2:233561755 GIGYF2 -0.63 -13.61 -0.47 3.18e-37 Coronary artery disease; BRCA cis rs3820928 0.839 rs4673174 chr2:227801316 A/T cg11843606 chr2:227700838 RHBDD1 -0.39 -8.72 -0.33 2.41e-17 Pulmonary function; BRCA trans rs9291683 0.546 rs4529049 chr4:10045389 C/T cg26043149 chr18:55253948 FECH 0.39 8.44 0.32 2.09e-16 Bone mineral density; BRCA cis rs9790314 0.632 rs778645 chr3:160707459 A/T cg03342759 chr3:160939853 NMD3 -0.47 -8.84 -0.33 9.1e-18 Morning vs. evening chronotype; BRCA cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -16.32 -0.54 2.48e-50 Chronic sinus infection; BRCA cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg16586182 chr3:47516702 SCAP -0.57 -12.77 -0.45 1.96e-33 Colorectal cancer; BRCA cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.17 0.43 8.91e-31 Mean platelet volume; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.36 -8.08 -0.3 3.32e-15 Longevity;Endometriosis; BRCA cis rs922182 1.000 rs1460546 chr15:64283108 C/A cg24729988 chr15:64271149 DAPK2 0.44 9.64 0.36 1.3e-20 Blood protein levels; BRCA cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg13010199 chr12:38710504 ALG10B 0.36 8.65 0.32 4.18e-17 Morning vs. evening chronotype; BRCA cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg11266682 chr4:10021025 SLC2A9 0.39 10.25 0.38 6.48e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg04727924 chr7:799746 HEATR2 -0.55 -10.86 -0.39 2.52e-25 Cerebrospinal P-tau181p levels; BRCA cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg09455208 chr3:40491958 NA -0.48 -11.9 -0.43 1.25e-29 Renal cell carcinoma; BRCA cis rs1538970 0.924 rs7528573 chr1:45913860 T/C cg05343316 chr1:45956843 TESK2 0.64 13.01 0.46 1.73e-34 Platelet count; BRCA cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg23711669 chr6:146136114 FBXO30 0.69 16.02 0.54 7.97e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg10802521 chr3:52805072 NEK4 -0.33 -8.44 -0.32 2.15e-16 Bipolar disorder; BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg00149659 chr3:10157352 C3orf10 0.79 13.66 0.48 1.77e-37 Alzheimer's disease; BRCA cis rs68170813 0.562 rs7810216 chr7:107000353 G/A cg02696742 chr7:106810147 HBP1 -0.55 -8.51 -0.32 1.22e-16 Coronary artery disease; BRCA cis rs11231017 0.507 rs10792351 chr11:62157472 T/C cg23876832 chr11:62092739 NA 0.32 8.04 0.3 4.4e-15 HIV-1 viral setpoint; BRCA cis rs7267979 1.000 rs761025 chr20:25426968 G/A cg08601574 chr20:25228251 PYGB 0.34 8.22 0.31 1.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs698833 0.547 rs1067348 chr2:44671409 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.44 0.32 2.06e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg21361702 chr7:150065534 REPIN1 0.55 10.03 0.37 4.29e-22 Blood protein levels;Circulating chemerin levels; BRCA cis rs34891900 0.507 rs12167823 chr22:18124362 G/A cg19898043 chr22:18121309 BCL2L13 0.46 9.24 0.34 3.75e-19 Sum neutrophil eosinophil counts; BRCA cis rs13118159 0.801 rs10024996 chr4:1328297 G/A cg01939980 chr4:1354348 KIAA1530 0.3 8.18 0.31 1.49e-15 Longevity; BRCA cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg20302533 chr7:39170763 POU6F2 0.4 8.45 0.32 1.92e-16 IgG glycosylation; BRCA cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg27165867 chr14:105738592 BRF1 -0.35 -8.93 -0.33 4.35e-18 Mean platelet volume;Platelet distribution width; BRCA cis rs6500602 0.701 rs1362626 chr16:4549226 C/G cg08645402 chr16:4508243 NA 0.37 8.96 0.33 3.46e-18 Schizophrenia; BRCA cis rs9287719 0.967 rs963831 chr2:10745184 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.07 -0.3 3.46e-15 Prostate cancer; BRCA cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg22875332 chr1:76189707 ACADM 0.8 19.03 0.6 2.6e-64 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10924970 0.781 rs10802590 chr1:235444051 A/G cg26050004 chr1:235667680 B3GALNT2 0.35 8.74 0.33 2.02e-17 Asthma; BRCA cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg17211192 chr8:82754475 SNX16 -0.53 -12.1 -0.43 1.69e-30 Diastolic blood pressure; BRCA cis rs941873 0.805 rs8837 chr10:81114813 C/G cg09469691 chr10:81107165 PPIF 0.5 10.12 0.37 2e-22 Height; BRCA trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg03929089 chr4:120376271 NA 0.63 12.45 0.44 5.31e-32 Coronary artery disease; BRCA cis rs732716 0.504 rs9352 chr19:4442336 C/T cg21934504 chr19:4445085 UBXN6 0.32 8.99 0.34 2.71e-18 Mean corpuscular volume; BRCA cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg15017067 chr4:17643749 FAM184B 0.28 8.41 0.32 2.64e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12368653 0.582 rs2307095 chr12:58026001 G/A cg18357645 chr12:58087776 OS9 0.34 9.16 0.34 6.91e-19 Multiple sclerosis; BRCA cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg11843238 chr5:131593191 PDLIM4 -0.36 -7.85 -0.3 1.73e-14 Breast cancer; BRCA cis rs9790314 0.747 rs1599378 chr3:160874511 A/C cg03342759 chr3:160939853 NMD3 -0.52 -10.43 -0.38 1.21e-23 Morning vs. evening chronotype; BRCA trans rs6952808 0.723 rs57216949 chr7:2030287 G/T cg04565464 chr8:145669602 NFKBIL2 0.38 9.0 0.34 2.63e-18 Bipolar disorder and schizophrenia; BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg12444411 chr7:2802554 GNA12 -0.34 -8.72 -0.33 2.36e-17 Height; BRCA cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.31e-54 Bladder cancer; BRCA cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg14847009 chr1:175162515 KIAA0040 0.25 9.67 0.36 1.01e-20 Alcohol dependence; BRCA cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg13010199 chr12:38710504 ALG10B 0.57 12.58 0.45 1.44e-32 Heart rate; BRCA cis rs3806843 0.900 rs116210441 chr5:140128649 T/A cg11822812 chr5:140052017 DND1 -0.33 -9.02 -0.34 2.21e-18 Depressive symptoms (multi-trait analysis); BRCA cis rs11229555 1.000 rs1938598 chr11:58413910 T/C cg15696309 chr11:58395628 NA -0.53 -11.59 -0.42 2.59e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6028335 0.674 rs59096774 chr20:37603529 A/G cg16355469 chr20:37678765 NA 0.47 8.54 0.32 9.61e-17 Alcohol and nicotine co-dependence; BRCA cis rs7766436 1.000 rs7766436 chr6:22598259 C/T cg13666174 chr6:22585274 NA -0.41 -10.07 -0.37 3.07e-22 Coronary artery disease; BRCA cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg05283184 chr6:79620031 NA -0.36 -8.17 -0.31 1.66e-15 Intelligence (multi-trait analysis); BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg24060327 chr5:131705240 SLC22A5 -0.42 -7.94 -0.3 9.32e-15 Acylcarnitine levels; BRCA cis rs2742234 0.590 rs1254962 chr10:43696992 G/A cg15436174 chr10:43711423 RASGEF1A 0.57 11.53 0.41 4.62e-28 Hirschsprung disease; BRCA cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg02734326 chr4:10020555 SLC2A9 0.39 8.19 0.31 1.44e-15 Bone mineral density; BRCA cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg25019033 chr10:957182 NA -0.41 -7.88 -0.3 1.45e-14 Eosinophil percentage of granulocytes; BRCA cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg06636001 chr8:8085503 FLJ10661 -0.52 -11.61 -0.42 2e-28 Mood instability; BRCA cis rs400736 0.655 rs55634431 chr1:8149549 G/A cg25007680 chr1:8021821 PARK7 -0.38 -8.94 -0.33 4.12e-18 Response to antidepressants and depression; BRCA trans rs208520 1.000 rs72882079 chr6:66973878 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.38 0.49 8.24e-41 Exhaled nitric oxide output; BRCA trans rs9325144 0.555 rs1843867 chr12:38703855 A/G cg23762105 chr12:34175262 ALG10 0.35 8.95 0.33 3.75e-18 Morning vs. evening chronotype; BRCA cis rs6456156 0.586 rs13210649 chr6:167473193 T/G cg07741184 chr6:167504864 NA 0.33 10.0 0.37 5.67e-22 Primary biliary cholangitis; BRCA cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 11.25 0.41 6.7399999999999993e-27 Personality dimensions; BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg18876405 chr7:65276391 NA -0.66 -16.98 -0.56 1.24e-53 Aortic root size; BRCA trans rs4689592 0.513 rs3857178 chr4:7066516 G/A cg07817883 chr1:32538562 TMEM39B -0.44 -8.51 -0.32 1.25e-16 Monocyte percentage of white cells; BRCA cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.11 -0.34 1.01e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12826209 chr6:26865740 GUSBL1 0.59 10.42 0.38 1.36e-23 Intelligence (multi-trait analysis); BRCA cis rs7412746 0.658 rs2275235 chr1:150730279 A/G cg15448220 chr1:150897856 SETDB1 0.36 8.25 0.31 8.93e-16 Melanoma; BRCA cis rs72781680 0.821 rs17046004 chr2:24144873 A/G cg08917208 chr2:24149416 ATAD2B 0.64 10.7 0.39 1.08e-24 Lymphocyte counts; BRCA cis rs600806 0.778 rs491285 chr1:110019002 C/T cg20591472 chr1:110008990 SYPL2 -0.31 -7.95 -0.3 8.63e-15 Intelligence (multi-trait analysis); BRCA cis rs11105298 0.786 rs10858867 chr12:89851166 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.94 -0.37 9.36e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9314323 0.592 rs12165 chr8:26269412 C/T cg13160058 chr8:26243215 BNIP3L -0.36 -10.32 -0.38 3.35e-23 Red cell distribution width; BRCA cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg11764359 chr7:65958608 NA -0.79 -19.02 -0.6 2.87e-64 Aortic root size; BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.01 21.57 0.65 5.99e-78 Gut microbiome composition (summer); BRCA cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg24110177 chr3:50126178 RBM5 -0.45 -9.92 -0.37 1.19e-21 Menarche (age at onset); BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg22009923 chr11:832065 CD151 -0.48 -10.6 -0.39 2.69e-24 Mean platelet volume; BRCA cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg16680214 chr1:154839983 KCNN3 -0.46 -12.9 -0.45 5.3e-34 Prostate cancer; BRCA cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.49e-15 Depression; BRCA cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.15 0.31 1.94e-15 Mean platelet volume; BRCA trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.14 -0.31 2.03e-15 Menarche (age at onset); BRCA cis rs561341 1.000 rs510264 chr17:30323414 A/G cg23018236 chr17:30244563 NA -0.68 -10.7 -0.39 1.09e-24 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg11752832 chr7:134001865 SLC35B4 -0.4 -9.72 -0.36 6.16e-21 Mean platelet volume; BRCA trans rs11250097 0.507 rs2409779 chr8:11311340 A/T cg06636001 chr8:8085503 FLJ10661 -0.5 -10.0 -0.37 5.52e-22 Neuroticism; BRCA cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.87 -0.43 1.67e-29 Electroencephalogram traits; BRCA cis rs7246657 0.525 rs10410594 chr19:37477758 C/T cg18154014 chr19:37997991 ZNF793 0.49 8.39 0.32 3.11e-16 Coronary artery calcification; BRCA cis rs3809566 1.000 rs4775612 chr15:63332157 T/C cg12160578 chr15:63334699 TPM1 -0.42 -8.48 -0.32 1.59e-16 Platelet count; BRCA cis rs2354432 0.607 rs6658763 chr1:146692373 C/T cg25205988 chr1:146714368 CHD1L -0.9 -11.32 -0.41 3.48e-27 Mitochondrial DNA levels; BRCA cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg05207973 chr5:176823642 SLC34A1 0.42 9.22 0.34 4.1e-19 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 4.98e-18 Motion sickness; BRCA cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg16989086 chr20:62203971 PRIC285 0.53 8.91 0.33 5.27e-18 Glioblastoma; BRCA cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg14440974 chr22:39074834 NA -0.38 -9.0 -0.34 2.64e-18 Menopause (age at onset); BRCA cis rs13108904 0.935 rs6853002 chr4:1295991 C/T cg00684032 chr4:1343700 KIAA1530 0.31 8.04 0.3 4.35e-15 Obesity-related traits; BRCA cis rs17376456 1.000 rs34013242 chr5:93507947 C/T cg21475434 chr5:93447410 FAM172A 0.67 8.75 0.33 1.94e-17 Diabetic retinopathy; BRCA cis rs7593730 0.636 rs3772071 chr2:161135544 C/T cg22609984 chr2:161126801 NA 0.38 8.32 0.31 5.4e-16 Type 2 diabetes; BRCA cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg24692254 chr21:30365293 RNF160 -0.62 -15.86 -0.53 5.22e-48 Dental caries; BRCA cis rs7945718 0.935 rs11022501 chr11:12809314 T/C cg25843174 chr11:12811716 TEAD1 0.23 8.91 0.33 5.12e-18 Educational attainment (years of education); BRCA cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg14343924 chr8:8086146 FLJ10661 0.4 8.41 0.32 2.74e-16 Mood instability; BRCA cis rs11583043 0.874 rs6577222 chr1:101420502 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.67 0.36 9.74e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs6121246 0.909 rs6060929 chr20:30345914 C/T cg13852791 chr20:30311386 BCL2L1 0.84 16.58 0.55 1.35e-51 Mean corpuscular hemoglobin; BRCA cis rs7587476 0.822 rs13018304 chr2:215682218 T/G cg04004882 chr2:215674386 BARD1 0.67 12.41 0.44 7.73e-32 Neuroblastoma; BRCA cis rs1538970 0.924 rs3790582 chr1:45887288 T/C cg05343316 chr1:45956843 TESK2 0.61 12.49 0.44 3.42e-32 Platelet count; BRCA cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg14530993 chr4:882597 GAK 0.59 9.54 0.35 2.98e-20 Intelligence (multi-trait analysis); BRCA cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg17211192 chr8:82754475 SNX16 0.49 11.0 0.4 6.82e-26 Diastolic blood pressure; BRCA cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg25767906 chr1:53392781 SCP2 0.38 8.7 0.33 2.83e-17 Monocyte count; BRCA cis rs3008870 1.000 rs3008856 chr1:67387901 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.58 0.65 5.31e-78 Lymphocyte percentage of white cells; BRCA trans rs9329221 0.710 rs11779205 chr8:10260100 C/T cg06636001 chr8:8085503 FLJ10661 0.48 9.24 0.34 3.67e-19 Neuroticism; BRCA trans rs453301 0.624 rs330049 chr8:9087299 C/T cg06636001 chr8:8085503 FLJ10661 0.57 13.0 0.46 1.87e-34 Joint mobility (Beighton score); BRCA cis rs473651 0.935 rs558924 chr2:239339511 A/G cg18131467 chr2:239335373 ASB1 0.86 21.85 0.65 1.88e-79 Multiple system atrophy; BRCA cis rs724568 0.527 rs12612262 chr2:67934125 G/C cg14046302 chr2:67939758 NA -0.38 -10.14 -0.37 1.72e-22 Major depressive disorder (broad); BRCA cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg24692254 chr21:30365293 RNF160 0.48 10.6 0.39 2.78e-24 Pancreatic cancer; BRCA cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg27446573 chr6:127587934 RNF146 0.89 21.1 0.64 2.1e-75 Breast cancer; BRCA cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg22974920 chr21:40686053 BRWD1 -0.35 -7.99 -0.3 6.32e-15 Menarche (age at onset); BRCA cis rs6684514 0.961 rs12126696 chr1:156241348 C/T cg16558208 chr1:156270281 VHLL 0.37 7.97 0.3 7.58e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12826209 chr6:26865740 GUSBL1 -0.59 -10.48 -0.38 8.28e-24 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs4712965 chr6:25742022 G/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg26384229 chr12:38710491 ALG10B -0.61 -14.68 -0.5 2.95e-42 Bladder cancer; BRCA cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -10.32 -0.38 3.51e-23 Autism spectrum disorder or schizophrenia; BRCA trans rs12517041 1.000 rs1428622 chr5:23286204 G/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA cis rs7267979 1.000 rs2500448 chr20:25404027 A/C cg08601574 chr20:25228251 PYGB -0.38 -8.94 -0.33 4.31e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg23283495 chr1:209979779 IRF6 0.38 9.11 0.34 1.02e-18 Cleft lip with or without cleft palate; BRCA cis rs3008870 1.000 rs1925408 chr1:67365034 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.96 21.6 0.65 4.41e-78 Lymphocyte percentage of white cells; BRCA cis rs7523273 0.606 rs2724391 chr1:207953244 T/C cg22525895 chr1:207977042 MIR29B2 0.47 11.92 0.43 1.02e-29 Schizophrenia; BRCA cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg21573476 chr21:45109991 RRP1B -0.35 -9.0 -0.34 2.64e-18 Mean corpuscular volume; BRCA cis rs7647973 0.961 rs7626076 chr3:49298139 G/A cg07636037 chr3:49044803 WDR6 0.68 13.58 0.47 4.29e-37 Menarche (age at onset); BRCA cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.55 -0.32 8.79e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs17270561 0.609 rs1408271 chr6:25859621 T/A cg17691542 chr6:26056736 HIST1H1C 0.53 10.85 0.39 2.74e-25 Iron status biomarkers; BRCA cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11890956 chr21:40555474 PSMG1 1.06 30.21 0.77 3.46e-125 Cognitive function; BRCA cis rs10189230 0.546 rs6436266 chr2:222357235 T/C cg14652038 chr2:222343519 EPHA4 0.37 8.89 0.33 6.3e-18 Urate levels in lean individuals; BRCA trans rs4332037 0.707 rs62435132 chr7:1891315 C/T cg11693508 chr17:37793320 STARD3 0.6 11.11 0.4 2.42e-26 Bipolar disorder; BRCA cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg13770153 chr20:60521292 NA -0.45 -10.92 -0.4 1.44e-25 Body mass index; BRCA cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg15145296 chr3:125709740 NA -0.54 -8.72 -0.33 2.31e-17 Blood pressure (smoking interaction); BRCA cis rs9646954 0.542 rs4149512 chr2:101022886 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.65 0.42 1.37e-28 Intelligence (multi-trait analysis); BRCA cis rs6435161 1.000 rs35202091 chr2:203507663 C/T cg18429434 chr2:203499731 FAM117B -0.43 -8.46 -0.32 1.77e-16 Total cholesterol levels; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg03709012 chr19:19516395 GATAD2A 0.72 15.68 0.53 4.14e-47 Tonsillectomy; BRCA cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.34 -0.35 1.6e-19 Alzheimer's disease (late onset); BRCA cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg18876405 chr7:65276391 NA 0.52 12.21 0.44 5.58e-31 Aortic root size; BRCA cis rs17376456 0.597 rs1031423 chr5:93276883 A/G cg25358565 chr5:93447407 FAM172A -0.53 -9.87 -0.36 1.79e-21 Diabetic retinopathy; BRCA trans rs12517041 1.000 rs7721619 chr5:23292676 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg07636037 chr3:49044803 WDR6 0.46 9.16 0.34 7.01e-19 Resting heart rate; BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.58 0.47 4.5e-37 Platelet count; BRCA cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -16.98 -0.56 1.25e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg03188948 chr7:1209495 NA 0.63 12.83 0.45 1.12e-33 Longevity;Endometriosis; BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.35 -0.44 1.39e-31 Lymphocyte counts; BRCA cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg22875332 chr1:76189707 ACADM 0.7 15.05 0.51 4.65e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.17 -0.34 6.24e-19 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg17063962 chr7:91808500 NA 0.61 14.56 0.5 1.08e-41 Breast cancer; BRCA cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg05025164 chr4:1340916 KIAA1530 -0.59 -12.28 -0.44 2.81e-31 Obesity-related traits; BRCA cis rs17270561 0.666 rs3923725 chr6:25734920 C/A cg17691542 chr6:26056736 HIST1H1C 0.49 9.29 0.34 2.44e-19 Iron status biomarkers; BRCA cis rs4595586 0.545 rs12823487 chr12:39391286 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs561341 0.769 rs8074383 chr17:30178793 C/T cg23018236 chr17:30244563 NA 0.61 8.75 0.33 1.95e-17 Hip circumference adjusted for BMI; BRCA cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg26248373 chr2:1572462 NA -0.47 -9.29 -0.34 2.48e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7149337 1.000 rs35567150 chr14:51725944 A/G cg23942311 chr14:51606299 NA 0.36 9.63 0.36 1.39e-20 Cancer; BRCA cis rs7582720 0.887 rs72934591 chr2:204019762 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.75 0.45 2.48e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs4803468 1.000 rs13344563 chr19:41945904 G/C cg09537434 chr19:41945824 ATP5SL 1.02 25.5 0.71 1.75e-99 Height; BRCA cis rs826838 0.559 rs4882276 chr12:38611994 T/C cg26384229 chr12:38710491 ALG10B 0.43 10.27 0.38 5.16e-23 Heart rate; BRCA cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg26373071 chr5:1325741 CLPTM1L 0.51 12.63 0.45 8.13e-33 Lung cancer; BRCA cis rs9612 1.000 rs346528 chr19:44259232 G/T cg08581076 chr19:44259116 C19orf61 0.53 9.74 0.36 5.59e-21 Exhaled nitric oxide output; BRCA cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg04756594 chr16:24857601 SLC5A11 0.54 12.2 0.43 6.23e-31 Intelligence (multi-trait analysis); BRCA cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg19628046 chr18:33552617 C18orf21 0.55 10.58 0.39 3.18e-24 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs35110281 0.776 rs62226866 chr21:45024186 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.37 0.38 2.09e-23 Mean corpuscular volume; BRCA cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg27535305 chr1:53392650 SCP2 -0.38 -9.28 -0.34 2.59e-19 Monocyte count; BRCA trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -8.91 -0.33 5.46e-18 HDL cholesterol; BRCA cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg20219911 chr3:52813652 ITIH1 0.3 8.27 0.31 7.65e-16 Bipolar disorder; BRCA cis rs10267417 0.657 rs6963367 chr7:19857873 A/C cg07541023 chr7:19748670 TWISTNB 0.51 9.08 0.34 1.3e-18 Night sleep phenotypes; BRCA cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg10556349 chr10:835070 NA 0.59 8.31 0.31 5.59e-16 Eosinophil percentage of granulocytes; BRCA cis rs10949834 0.504 rs150862 chr7:73524207 C/T cg07137043 chr7:73588983 EIF4H 0.51 8.72 0.33 2.42e-17 Verbal memory performance (residualized delayed recall change); BRCA trans rs11764590 0.671 rs56226325 chr7:2078981 C/T cg11693508 chr17:37793320 STARD3 0.52 9.14 0.34 8.43e-19 Neuroticism; BRCA cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg10523679 chr1:76189770 ACADM 0.78 18.91 0.6 1.14e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg15556689 chr8:8085844 FLJ10661 0.44 12.34 0.44 1.55e-31 Neuroticism; BRCA cis rs7172677 0.737 rs8025412 chr15:75444033 C/T cg10253484 chr15:75165896 SCAMP2 -0.41 -7.91 -0.3 1.15e-14 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg25817165 chr18:72167213 CNDP2 -0.77 -19.89 -0.62 6.7e-69 Refractive error; BRCA cis rs733592 0.507 rs7304428 chr12:48494275 T/G cg24011408 chr12:48396354 COL2A1 -0.42 -9.31 -0.35 1.97e-19 Plateletcrit; BRCA cis rs6964587 0.933 rs28671255 chr7:91770705 A/G cg17063962 chr7:91808500 NA 0.61 14.46 0.5 3.48e-41 Breast cancer; BRCA cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg26408565 chr15:76604113 ETFA -0.48 -10.3 -0.38 3.98e-23 Blood metabolite levels; BRCA cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.35 -12.8 -0.45 1.47e-33 Autism spectrum disorder or schizophrenia; BRCA cis rs8062405 0.755 rs7186573 chr16:28587389 T/C cg16576597 chr16:28551801 NUPR1 0.33 9.04 0.34 1.88e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg04025307 chr7:1156635 C7orf50 0.59 15.01 0.51 7.24e-44 Longevity;Endometriosis; BRCA cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg06627628 chr2:24431161 ITSN2 -0.54 -8.81 -0.33 1.15e-17 Lymphocyte counts; BRCA cis rs561341 1.000 rs501957 chr17:30314504 C/T cg12193833 chr17:30244370 NA -0.52 -8.41 -0.32 2.7e-16 Hip circumference adjusted for BMI; BRCA cis rs6964587 0.626 rs68009402 chr7:91516226 G/A cg17063962 chr7:91808500 NA -0.55 -12.75 -0.45 2.49e-33 Breast cancer; BRCA trans rs11098499 0.780 rs12504773 chr4:120562149 G/C cg25214090 chr10:38739885 LOC399744 0.53 11.67 0.42 1.12e-28 Corneal astigmatism; BRCA cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05535760 chr7:792225 HEATR2 0.87 14.93 0.51 1.94e-43 Cerebrospinal P-tau181p levels; BRCA trans rs747782 0.527 rs7113857 chr11:48141859 G/T cg15704280 chr7:45808275 SEPT13 0.56 7.94 0.3 9.45e-15 Intraocular pressure; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg21747090 chr2:27597821 SNX17 -0.41 -9.16 -0.34 7.07e-19 Total body bone mineral density; BRCA cis rs7267979 1.000 rs2856 chr20:25433536 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.87 0.33 7.45e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10733682 0.715 rs3814119 chr9:129462901 A/G cg00232160 chr9:129468157 NA 0.37 8.8 0.33 1.22e-17 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs708547 0.581 rs13121027 chr4:57813369 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.44 8.55 0.32 9.34e-17 Response to bleomycin (chromatid breaks); BRCA cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg01483505 chr11:975446 AP2A2 0.34 9.2 0.34 5.11e-19 Alzheimer's disease (late onset); BRCA trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg03929089 chr4:120376271 NA -0.49 -9.5 -0.35 4.01e-20 HDL cholesterol; BRCA cis rs9814567 0.806 rs4074521 chr3:134325536 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.36 8.18 0.31 1.51e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05535760 chr7:792225 HEATR2 0.85 14.37 0.49 8.79e-41 Cerebrospinal P-tau181p levels; BRCA cis rs7555523 0.887 rs6696454 chr1:165707923 T/C cg24409356 chr1:165738333 TMCO1 0.51 8.19 0.31 1.46e-15 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs6032067 0.561 rs6032104 chr20:43932412 G/A cg06407657 chr20:43937138 MATN4;RBPJL 0.29 8.03 0.3 4.75e-15 Blood protein levels; BRCA cis rs34779708 0.931 rs9663401 chr10:35278849 G/T cg03585969 chr10:35415529 CREM 0.57 11.51 0.41 5.35e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs7647973 0.626 rs11130217 chr3:49737323 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.13 -0.31 2.22e-15 Menarche (age at onset); BRCA cis rs13046373 0.507 rs8133828 chr21:32033046 C/G cg16812893 chr21:31813075 KRTAP15-1 0.36 8.58 0.32 7.03e-17 HDL cholesterol; BRCA cis rs78487399 0.908 rs6749617 chr2:43845329 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.52 8.07 0.3 3.47e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs7833986 0.501 rs72653941 chr8:56942247 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.67 13.0 0.46 1.85e-34 Height; BRCA cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.39 -0.32 3.03e-16 IgG glycosylation; BRCA cis rs9467773 0.967 rs1535276 chr6:26520941 T/C cg09904177 chr6:26538194 HMGN4 0.57 18.49 0.59 1.76e-61 Intelligence (multi-trait analysis); BRCA cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg08798685 chr6:27730294 NA -0.4 -7.82 -0.3 2.23e-14 Parkinson's disease; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg15112475 chr7:1198522 ZFAND2A -0.38 -9.1 -0.34 1.13e-18 Longevity;Endometriosis; BRCA cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.13 -0.34 8.58e-19 Menopause (age at onset); BRCA cis rs9304742 0.962 rs1044467 chr19:53452769 A/G cg09915433 chr19:53449742 NA -0.82 -20.11 -0.62 4.69e-70 Psoriasis; BRCA cis rs2346177 0.875 rs1447565 chr2:46643682 T/A cg02822958 chr2:46747628 ATP6V1E2 0.41 8.58 0.32 6.92e-17 HDL cholesterol; BRCA cis rs4808199 0.739 rs2240117 chr19:19418916 C/T cg03709012 chr19:19516395 GATAD2A 0.85 12.69 0.45 4.46e-33 Nonalcoholic fatty liver disease; BRCA cis rs6733011 0.578 rs11893888 chr2:99495239 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.35 -8.06 -0.3 3.68e-15 Bipolar disorder; BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 18.0 0.58 6.37e-59 Platelet count; BRCA trans rs801193 0.613 rs2016325 chr7:66323500 T/C cg18876405 chr7:65276391 NA -0.51 -11.6 -0.42 2.34e-28 Aortic root size; BRCA cis rs7072216 0.763 rs10748729 chr10:100171371 G/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA trans rs1422110 0.513 rs1422105 chr5:85448371 A/C cg01787110 chr1:109008453 NBPF6 0.36 8.01 0.3 5.6e-15 Attention function in attention deficit hyperactive disorder; BRCA cis rs11229555 1.000 rs2298608 chr11:58404467 A/G cg15696309 chr11:58395628 NA 0.52 11.48 0.41 7.14e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -11.8 -0.42 3.22e-29 Intelligence (multi-trait analysis); BRCA cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg13770153 chr20:60521292 NA -0.41 -9.12 -0.34 9.89e-19 Body mass index; BRCA trans rs11098499 0.604 rs2389882 chr4:120566733 A/C cg25214090 chr10:38739885 LOC399744 0.49 10.4 0.38 1.59e-23 Corneal astigmatism; BRCA trans rs61931739 0.635 rs10743836 chr12:33961680 C/T cg26384229 chr12:38710491 ALG10B 0.39 8.87 0.33 7e-18 Morning vs. evening chronotype; BRCA cis rs858239 0.600 rs10266123 chr7:23136487 G/C cg23682824 chr7:23144976 KLHL7 0.42 11.32 0.41 3.34e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs6570726 0.935 rs422540 chr6:145837815 G/T cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs10089 0.953 rs10463839 chr5:127519675 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 13.44 0.47 1.93e-36 Ileal carcinoids; BRCA cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg17143192 chr8:8559678 CLDN23 0.52 10.06 0.37 3.48e-22 Obesity-related traits; BRCA cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg00031303 chr3:195681400 NA 0.45 8.55 0.32 9.31e-17 Pancreatic cancer; BRCA cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.52 10.1 0.37 2.4e-22 Lung cancer in ever smokers; BRCA cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11890956 chr21:40555474 PSMG1 -0.82 -20.61 -0.63 9.89e-73 Cognitive function; BRCA cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg22862634 chr11:62369728 EML3;MTA2 0.56 13.26 0.46 1.2e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg23711669 chr6:146136114 FBXO30 0.72 16.53 0.55 2.2e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg25173405 chr17:45401733 C17orf57 -0.52 -11.12 -0.4 2.26e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg25206134 chr2:45395956 NA 0.55 9.06 0.34 1.55e-18 Bipolar disorder; BRCA cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.61 11.23 0.41 7.49e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs11190604 1.000 rs10883501 chr10:102238326 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.34 0.41 2.78e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg26149184 chr10:133730230 NA 0.39 7.88 0.3 1.46e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg02659138 chr7:134003124 SLC35B4 0.32 9.78 0.36 3.74e-21 Mean platelet volume; BRCA cis rs1451375 0.755 rs3829897 chr7:50629764 G/T cg18232548 chr7:50535776 DDC 0.4 9.73 0.36 5.85e-21 Malaria; BRCA cis rs858239 0.539 rs10280815 chr7:23188370 A/C cg23682824 chr7:23144976 KLHL7 0.42 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.44 0.35 6.79e-20 Motion sickness; BRCA cis rs9790314 1.000 rs9872514 chr3:161042833 T/C cg04691961 chr3:161091175 C3orf57 -0.52 -12.88 -0.45 6.43e-34 Morning vs. evening chronotype; BRCA cis rs12760731 0.565 rs34593395 chr1:178129488 C/T cg00404053 chr1:178313656 RASAL2 0.64 7.86 0.3 1.67e-14 Obesity-related traits; BRCA cis rs1971762 0.563 rs7958775 chr12:54077556 T/C cg23533419 chr12:54090519 NA -0.33 -8.37 -0.31 3.55e-16 Height; BRCA cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg26384229 chr12:38710491 ALG10B 0.66 15.22 0.52 7.19e-45 Drug-induced liver injury (flucloxacillin); BRCA cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -11.66 -0.42 1.34e-28 Personality dimensions; BRCA trans rs9291683 0.692 rs1558489 chr4:10325489 T/A cg26043149 chr18:55253948 FECH -0.41 -8.88 -0.33 6.9e-18 Bone mineral density; BRCA cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg07549590 chr16:15018862 NA -0.49 -12.34 -0.44 1.63e-31 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs877529 1.000 rs713909 chr22:39532420 G/C cg12193277 chr22:39547181 CBX7 0.46 12.74 0.45 2.63e-33 Multiple myeloma; BRCA cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.77 -0.42 4.32e-29 Alcohol dependence; BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.57 -0.32 7.64e-17 Total body bone mineral density; BRCA cis rs17376456 0.778 rs10440717 chr5:93424852 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.08 0.3 3.12e-15 Diabetic retinopathy; BRCA cis rs4595586 0.525 rs6580891 chr12:39370127 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg11266682 chr4:10021025 SLC2A9 0.37 9.56 0.35 2.56e-20 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2304069 0.817 rs216132 chr5:149431259 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.69 -14.34 -0.49 1.24e-40 HIV-1 control; BRCA cis rs16944613 0.541 rs7494949 chr15:91090394 C/G cg26821196 chr15:91095069 CRTC3 0.47 8.55 0.32 9.42e-17 Colorectal cancer; BRCA cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -11.95 -0.43 7.54e-30 Personality dimensions; BRCA cis rs6545883 0.525 rs1729662 chr2:61391305 G/A cg15711740 chr2:61764176 XPO1 -0.46 -11.27 -0.41 5.43e-27 Tuberculosis; BRCA cis rs586533 0.678 rs669951 chr11:99499468 G/T cg22878054 chr11:99397252 CNTN5 0.32 8.07 0.3 3.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg02353165 chr6:42928485 GNMT 0.88 23.75 0.68 7.12e-90 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6723226 0.750 rs3769597 chr2:32691400 T/G cg02381751 chr2:32503542 YIPF4 0.48 10.21 0.37 8.62e-23 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.657 rs9996569 chr4:120299004 G/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg12386194 chr3:101231763 SENP7 0.46 9.76 0.36 4.58e-21 Colorectal cancer; BRCA cis rs9400271 0.527 rs60248809 chr6:109640690 A/C cg01475377 chr6:109611718 NA 0.36 7.96 0.3 7.97e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs11148252 0.846 rs7323666 chr13:53006058 T/C cg00495681 chr13:53174319 NA 0.42 8.98 0.33 2.98e-18 Lewy body disease; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.39e-15 Menopause (age at onset); BRCA cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg11742103 chr11:62369870 EML3;MTA2 0.53 13.53 0.47 7.47e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2066819 1.000 rs17118409 chr12:56630764 G/A cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs2731664 0.792 rs652242 chr5:176873010 C/G cg23176889 chr5:176863531 GRK6 -0.61 -16.61 -0.55 8.84e-52 Intelligence (multi-trait analysis); BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg00106254 chr7:1943704 MAD1L1 -0.35 -9.26 -0.34 3.18e-19 Schizophrenia; BRCA cis rs62380364 0.542 rs2457979 chr5:88039660 T/A cg22951263 chr5:87985283 NA -0.38 -10.56 -0.39 3.86e-24 Intelligence (multi-trait analysis); BRCA cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.41 7.84 0.3 1.93e-14 Tuberculosis; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg03885332 chr11:832357 CD151 -0.33 -9.45 -0.35 6.31e-20 Mean platelet volume; BRCA cis rs113835537 0.597 rs57288351 chr11:66307489 C/T cg24851651 chr11:66362959 CCS 0.48 8.73 0.33 2.15e-17 Airway imaging phenotypes; BRCA cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg14440974 chr22:39074834 NA -0.38 -9.0 -0.34 2.64e-18 Menopause (age at onset); BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.39e-15 Menopause (age at onset); BRCA trans rs11098499 0.863 rs3822191 chr4:120428101 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.12 0.31 2.33e-15 Corneal astigmatism; BRCA cis rs858239 0.601 rs73272048 chr7:23152653 C/G cg23682824 chr7:23144976 KLHL7 0.45 12.04 0.43 3.16e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs7772486 0.754 rs702324 chr6:146008793 A/G cg23711669 chr6:146136114 FBXO30 -0.75 -15.96 -0.53 1.59e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs2455601 0.786 rs11042127 chr11:8947586 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -9.03 -0.34 2.02e-18 Schizophrenia; BRCA trans rs9291683 0.527 rs73212848 chr4:10093299 T/C cg26043149 chr18:55253948 FECH -0.41 -8.73 -0.33 2.29e-17 Bone mineral density; BRCA cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs3733585 0.673 rs4627861 chr4:9954238 T/G cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 8.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9392556 0.829 rs619873 chr6:4107455 A/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.39 -8.64 -0.32 4.63e-17 Blood metabolite levels; BRCA trans rs11098499 0.865 rs10213221 chr4:120255926 G/A cg25214090 chr10:38739885 LOC399744 0.46 10.6 0.39 2.72e-24 Corneal astigmatism; BRCA cis rs782590 0.533 rs2008040 chr2:55687290 G/C cg18811423 chr2:55921094 PNPT1 0.46 11.99 0.43 5.35e-30 Metabolic syndrome; BRCA cis rs829883 0.622 rs7302630 chr12:98959577 C/A cg25150519 chr12:98850993 NA -0.46 -8.46 -0.32 1.82e-16 Colorectal adenoma (advanced); BRCA cis rs6594499 0.872 rs6865932 chr5:110436852 G/C cg04022379 chr5:110408740 TSLP 0.35 8.01 0.3 5.51e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg27129171 chr3:47204927 SETD2 -0.64 -14.38 -0.49 8.27e-41 Colorectal cancer; BRCA cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.57 -0.42 3.14e-28 Bipolar disorder; BRCA cis rs7103648 0.966 rs1377416 chr11:47416746 C/T cg03711944 chr11:47377212 SPI1 -0.43 -11.64 -0.42 1.51e-28 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.26 -9.11 -0.34 1.08e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs365132 1.000 rs35977534 chr5:176335231 T/C cg16309518 chr5:176445507 NA -0.52 -13.38 -0.47 3.71e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7635838 0.596 rs347599 chr3:11258191 C/T cg00170343 chr3:11313890 ATG7 -0.42 -8.42 -0.32 2.44e-16 HDL cholesterol; BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg27170947 chr2:26402098 FAM59B -0.65 -10.98 -0.4 8.46e-26 Gut microbiome composition (summer); BRCA cis rs7824557 0.569 rs35418978 chr8:11186453 T/C cg21775007 chr8:11205619 TDH 0.71 17.28 0.56 3.32e-55 Retinal vascular caliber; BRCA cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.1 0.4 2.74e-26 Coronary artery disease; BRCA cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg25809561 chr17:30822961 MYO1D 0.4 9.26 0.34 2.96e-19 Schizophrenia; BRCA trans rs7615952 0.512 rs4234285 chr3:125404477 G/A cg07211511 chr3:129823064 LOC729375 -0.57 -10.52 -0.38 5.52e-24 Blood pressure (smoking interaction); BRCA cis rs34734847 1.000 rs2948149 chr12:121162854 T/G cg21892295 chr12:121157589 UNC119B -0.42 -13.07 -0.46 9.58e-35 Mean corpuscular volume; BRCA cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg16339924 chr4:17578868 LAP3 0.56 13.9 0.48 1.42e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg08888203 chr3:10149979 C3orf24 0.67 14.45 0.5 3.77e-41 Alzheimer's disease; BRCA cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg27279351 chr12:120934652 DYNLL1 0.51 12.25 0.44 3.95e-31 High light scatter reticulocyte count; BRCA cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg21545522 chr1:205238299 TMCC2 0.4 8.8 0.33 1.29e-17 Mean corpuscular volume;Mean platelet volume; BRCA cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg09526685 chr4:187126073 CYP4V2 -0.96 -11.81 -0.42 2.99e-29 Blood protein levels; BRCA cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg06115741 chr20:33292138 TP53INP2 -0.37 -8.22 -0.31 1.17e-15 Glomerular filtration rate (creatinine); BRCA cis rs7631605 0.905 rs9822082 chr3:37086204 G/A cg15934958 chr3:37212084 LRRFIP2 0.41 9.33 0.35 1.69e-19 Cerebrospinal P-tau181p levels; BRCA cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg01874867 chr7:94954059 PON1 -0.39 -7.97 -0.3 7.31e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg11764359 chr7:65958608 NA 0.66 12.08 0.43 2.07e-30 Aortic root size; BRCA cis rs13046373 0.508 rs1911572 chr21:32031648 A/G cg24082983 chr21:31802169 KRTAP13-4 -0.34 -8.56 -0.32 8.65e-17 HDL cholesterol; BRCA cis rs62005083 0.500 rs10135300 chr14:74574561 G/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.52 8.95 0.33 3.72e-18 Mean corpuscular volume; BRCA cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg04414720 chr1:150670196 GOLPH3L 0.36 8.28 0.31 7.19e-16 Tonsillectomy; BRCA cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg08085267 chr17:45401833 C17orf57 0.67 14.61 0.5 6.47e-42 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3824867 0.920 rs7948705 chr11:47447955 C/G cg20307385 chr11:47447363 PSMC3 -0.49 -11.0 -0.4 7.1e-26 Mean corpuscular hemoglobin; BRCA cis rs10746514 0.768 rs11122427 chr1:232261085 C/T cg09506761 chr1:232265262 NA -0.42 -8.66 -0.32 3.86e-17 Response to statin therapy; BRCA cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg01939980 chr4:1354348 KIAA1530 0.37 8.73 0.33 2.23e-17 Obesity-related traits; BRCA cis rs4906332 0.966 rs12894275 chr14:103901424 A/G cg04998671 chr14:104000505 TRMT61A 0.41 8.94 0.33 4.31e-18 Coronary artery disease; BRCA cis rs3771570 0.901 rs73008106 chr2:242422446 C/T cg21155796 chr2:242212141 HDLBP 0.52 8.49 0.32 1.41e-16 Prostate cancer; BRCA cis rs28374715 0.662 rs513280 chr15:41482800 T/C cg18705301 chr15:41695430 NDUFAF1 0.78 16.93 0.56 2.19e-53 Ulcerative colitis; BRCA cis rs950776 0.616 rs56276142 chr15:78889795 T/C cg06917634 chr15:78832804 PSMA4 0.58 12.5 0.44 3.28e-32 Sudden cardiac arrest; BRCA cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg12863693 chr15:85201151 NMB 0.4 9.18 0.34 5.7e-19 P wave terminal force; BRCA cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.12 0.43 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg15704280 chr7:45808275 SEPT13 -0.77 -17.34 -0.57 1.8e-55 Coronary artery disease; BRCA cis rs17818399 0.548 rs1989720 chr2:46854364 C/T cg02822958 chr2:46747628 ATP6V1E2 0.42 8.31 0.31 5.84e-16 Height; BRCA cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg05234568 chr11:5960015 NA -0.43 -8.83 -0.33 1.01e-17 DNA methylation (variation); BRCA cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.98 0.3 6.99e-15 Depression; BRCA cis rs4478858 0.611 rs7527645 chr1:31763787 T/C cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.35 0.31 4.22e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg11814155 chr7:99998594 ZCWPW1 0.49 8.77 0.33 1.57e-17 Platelet count; BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg11062466 chr8:58055876 NA 0.54 9.15 0.34 7.78e-19 Developmental language disorder (linguistic errors); BRCA cis rs7582720 1.000 rs72934537 chr2:203969504 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.77 0.45 2.02e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs4237845 0.537 rs59401446 chr12:58259564 G/A cg00677455 chr12:58241039 CTDSP2 0.64 16.16 0.54 1.62e-49 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.524 rs28542490 chr19:37456584 C/A cg23950597 chr19:37808831 NA -0.58 -9.19 -0.34 5.47e-19 Coronary artery calcification; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg21747090 chr2:27597821 SNX17 -0.45 -9.65 -0.36 1.2e-20 Total body bone mineral density; BRCA cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.83 -0.36 2.47e-21 Tonsillectomy; BRCA cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg13010199 chr12:38710504 ALG10B 0.41 8.37 0.31 3.59e-16 Bladder cancer; BRCA cis rs5167 0.504 rs73047641 chr19:45457377 G/A cg20090143 chr19:45452003 APOC2 0.27 7.9 0.3 1.18e-14 Blood protein levels; BRCA cis rs870825 0.616 rs877276 chr4:185621249 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA trans rs7819412 0.505 rs17726209 chr8:11022185 C/T cg15556689 chr8:8085844 FLJ10661 0.33 8.05 0.3 4.14e-15 Triglycerides; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg11843238 chr5:131593191 PDLIM4 0.36 9.32 0.35 1.81e-19 Breast cancer; BRCA trans rs1493916 0.592 rs1389068 chr18:31312738 G/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.15 -0.31 1.89e-15 Life satisfaction; BRCA cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg04981885 chr1:160991156 F11R -0.55 -10.12 -0.37 2.07e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg05863683 chr7:1912471 MAD1L1 0.37 8.39 0.31 3.21e-16 Bipolar disorder and schizophrenia; BRCA cis rs4763879 0.865 rs4763840 chr12:9884410 A/G cg27502298 chr12:9555721 NA 0.41 7.92 0.3 1.05e-14 Type 1 diabetes; BRCA cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg13736514 chr6:26305472 NA -0.36 -12.24 -0.44 4.46e-31 Educational attainment; BRCA cis rs10788264 0.538 rs1998344 chr10:124030137 A/G cg09507567 chr10:124027408 NA 0.38 7.96 0.3 7.94e-15 Total body bone mineral density; BRCA cis rs2070488 1.000 rs1002676 chr3:38444932 A/C cg24069376 chr3:38537580 EXOG -0.38 -10.78 -0.39 5.09e-25 Electrocardiographic conduction measures; BRCA cis rs1865760 0.566 rs3752420 chr6:26027135 G/A cg17691542 chr6:26056736 HIST1H1C 0.55 11.56 0.42 3.39e-28 Height; BRCA cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.6 -13.88 -0.48 1.76e-38 Personality dimensions; BRCA cis rs7617773 0.963 rs6800730 chr3:48174210 C/T cg11946769 chr3:48343235 NME6 0.38 8.19 0.31 1.44e-15 Coronary artery disease; BRCA cis rs6840360 0.615 rs12647586 chr4:152607568 G/C cg22705602 chr4:152727874 NA -0.38 -10.16 -0.37 1.41e-22 Intelligence (multi-trait analysis); BRCA cis rs6901004 0.935 rs1150078 chr6:111560301 C/T cg15721981 chr6:111408429 SLC16A10 0.36 7.91 0.3 1.1e-14 Blood metabolite levels; BRCA cis rs4594175 0.886 rs11157802 chr14:51622984 C/T cg23942311 chr14:51606299 NA 0.33 8.46 0.32 1.83e-16 Cancer; BRCA cis rs13053817 1.000 rs7290855 chr22:29852474 G/A cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.47 -9.04 -0.34 1.81e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs9790314 1.000 rs1478565 chr3:161027464 C/T cg03342759 chr3:160939853 NMD3 -0.64 -13.47 -0.47 1.36e-36 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs11928499 chr3:134232350 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.64 0.61 1.56e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26314531 chr2:26401878 FAM59B -0.66 -11.2 -0.4 1.08e-26 Gut microbiome composition (summer); BRCA cis rs4642101 0.662 rs4034942 chr3:12836792 C/T cg24848339 chr3:12840334 CAND2 0.52 14.13 0.49 1.16e-39 QRS complex (12-leadsum); BRCA cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg00339695 chr16:24857497 SLC5A11 0.49 9.75 0.36 5.07e-21 Intelligence (multi-trait analysis); BRCA cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg06697600 chr4:7070879 GRPEL1 0.6 10.09 0.37 2.65e-22 Monocyte percentage of white cells; BRCA cis rs7020830 0.861 rs6476622 chr9:37308049 T/A cg14294708 chr9:37120828 ZCCHC7 1.14 38.09 0.83 1.42e-166 Schizophrenia; BRCA cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg21132104 chr15:45694354 SPATA5L1 -0.61 -12.65 -0.45 6.64e-33 Homoarginine levels; BRCA cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg15605315 chr1:45957053 TESK2 0.46 9.4 0.35 9.8e-20 High light scatter reticulocyte count; BRCA cis rs10193935 0.892 rs13413028 chr2:42394865 C/G cg27598129 chr2:42591480 NA -0.93 -14.94 -0.51 1.59e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14240646 chr10:27532245 ACBD5 -0.62 -9.58 -0.35 2.13e-20 Breast cancer; BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg05896524 chr21:47604654 C21orf56 0.51 10.35 0.38 2.66e-23 Testicular germ cell tumor; BRCA cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg13319975 chr6:146136371 FBXO30 -0.46 -10.5 -0.38 6.96e-24 Lobe attachment (rater-scored or self-reported); BRCA trans rs3812049 0.826 rs2409110 chr5:127433047 A/T cg16011800 chr17:1958478 HIC1 -0.56 -9.04 -0.34 1.84e-18 Lymphocyte counts;Red cell distribution width; BRCA cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg26384229 chr12:38710491 ALG10B 0.73 17.55 0.57 1.36e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs7582720 0.943 rs72934546 chr2:203980033 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.77 0.45 2.02e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg04267008 chr7:1944627 MAD1L1 -0.58 -12.71 -0.45 3.61e-33 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg23711669 chr6:146136114 FBXO30 -0.8 -19.25 -0.61 1.69e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.17 0.34 6.54e-19 Alzheimer's disease; BRCA cis rs701145 0.938 rs701135 chr3:154065455 C/G cg17054900 chr3:154042577 DHX36 0.66 11.41 0.41 1.46e-27 Coronary artery disease; BRCA cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg24692254 chr21:30365293 RNF160 0.79 21.82 0.65 2.72e-79 Dental caries; BRCA cis rs7131987 0.621 rs6487805 chr12:29457550 A/T cg09582351 chr12:29534625 ERGIC2 0.41 9.34 0.35 1.5700000000000001e-19 QT interval; BRCA cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg16482183 chr6:26056742 HIST1H1C 0.5 10.33 0.38 3.04e-23 Height; BRCA cis rs17376456 0.542 rs1982439 chr5:93160560 C/G cg25358565 chr5:93447407 FAM172A -0.66 -11.52 -0.41 4.79e-28 Diabetic retinopathy; BRCA trans rs4819388 0.915 rs4818892 chr21:45650085 A/G cg17383793 chr5:52405638 MOCS2 0.48 11.03 0.4 5.02e-26 Celiac disease; BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg04944784 chr2:26401820 FAM59B -0.74 -11.86 -0.42 1.87e-29 Gut microbiome composition (summer); BRCA trans rs10805346 0.531 rs12498927 chr4:10115523 C/T cg26043149 chr18:55253948 FECH -0.44 -10.26 -0.38 5.8e-23 Urate levels in overweight individuals;Urate levels in obese individuals; BRCA cis rs365132 1.000 rs353490 chr5:176433063 C/T cg16309518 chr5:176445507 NA -0.51 -13.2 -0.46 2.28e-35 Menarche and menopause (age at onset);Menopause (age at onset); BRCA trans rs7944735 0.517 rs11039538 chr11:48154990 A/T cg15704280 chr7:45808275 SEPT13 0.57 8.09 0.3 3.11e-15 Intraocular pressure; BRCA cis rs34779708 0.966 rs11010129 chr10:35510822 T/C cg03585969 chr10:35415529 CREM 0.49 10.09 0.37 2.59e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg18876405 chr7:65276391 NA -0.55 -13.02 -0.46 1.6e-34 Aortic root size; BRCA cis rs7095944 0.614 rs4962697 chr10:126447545 G/C cg08799069 chr10:126477246 METTL10 -0.4 -9.44 -0.35 7.08e-20 Asthma; BRCA cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg24920358 chr1:40204285 PPIE 0.33 7.81 0.3 2.3e-14 Blood protein levels; BRCA cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg21017887 chr14:105400489 NA -0.64 -17.16 -0.56 1.49e-54 Rheumatoid arthritis; BRCA trans rs826838 0.709 rs4882355 chr12:38721462 A/T cg23762105 chr12:34175262 ALG10 -0.41 -10.1 -0.37 2.42e-22 Heart rate; BRCA cis rs17253792 0.822 rs10083493 chr14:56045411 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.71e-16 Putamen volume; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg22903471 chr2:27725779 GCKR -0.39 -9.72 -0.36 6.26e-21 Total body bone mineral density; BRCA cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg18964960 chr10:1102726 WDR37 -0.51 -8.91 -0.33 5.36e-18 Response to angiotensin II receptor blocker therapy; BRCA cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg10253484 chr15:75165896 SCAMP2 0.48 9.54 0.35 2.92e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA trans rs634534 0.532 rs12794370 chr11:65770413 G/A cg17712092 chr4:129076599 LARP1B 0.54 13.08 0.46 8.18e-35 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7917772 0.636 rs1475644 chr10:104491164 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 10.66 0.39 1.53e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg03929089 chr4:120376271 NA 0.47 8.42 0.32 2.55e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs4808199 0.947 rs2163804 chr19:19575965 G/A cg03709012 chr19:19516395 GATAD2A 1.08 20.88 0.64 3.37e-74 Nonalcoholic fatty liver disease; BRCA cis rs11112613 0.713 rs55646142 chr12:105949557 G/A cg03607813 chr12:105948248 NA 0.6 11.21 0.41 9.41e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg08045932 chr20:61659980 NA 0.49 11.18 0.4 1.31e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs8114671 0.562 rs7263157 chr20:33459127 G/A cg07148914 chr20:33460835 GGT7 0.45 9.65 0.36 1.18e-20 Height; BRCA cis rs11702148 0.552 rs2154583 chr21:34888940 T/G cg14850771 chr21:34775459 IFNGR2 0.36 8.08 0.3 3.35e-15 Mean corpuscular hemoglobin; BRCA cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg00530320 chr1:46809349 NSUN4 0.48 9.78 0.36 3.87e-21 Menopause (age at onset); BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 19.53 0.61 5.96e-67 Platelet count; BRCA cis rs7267979 1.000 rs2258201 chr20:25272490 G/C cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg04025307 chr7:1156635 C7orf50 0.47 9.42 0.35 8.26e-20 Bronchopulmonary dysplasia; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.33e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg23422044 chr7:1970798 MAD1L1 -0.56 -9.64 -0.36 1.29e-20 Neuroticism; BRCA cis rs6545883 0.859 rs35760550 chr2:61603865 T/A cg15711740 chr2:61764176 XPO1 0.5 12.18 0.43 8.05e-31 Tuberculosis; BRCA cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs55692411 0.537 rs13071931 chr3:50062878 G/A cg05623727 chr3:50126028 RBM5 0.45 8.55 0.32 9.1e-17 Intelligence (multi-trait analysis); BRCA cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg15017067 chr4:17643749 FAM184B -0.29 -8.78 -0.33 1.49e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs35110281 0.807 rs2838326 chr21:45014315 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.36 7.91 0.3 1.13e-14 Mean corpuscular volume; BRCA cis rs4919694 1.000 rs58317752 chr10:104799267 T/A cg04362960 chr10:104952993 NT5C2 0.94 14.5 0.5 2.26e-41 Arsenic metabolism; BRCA cis rs7098414 0.511 rs12262228 chr10:82160425 C/T cg00277334 chr10:82204260 NA -0.48 -10.1 -0.37 2.42e-22 Post bronchodilator FEV1; BRCA cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg16179182 chr5:140090404 VTRNA1-1 -0.46 -10.75 -0.39 7.03e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs8038465 0.622 rs17185525 chr15:73885539 T/C cg15420318 chr15:73925796 NPTN 0.48 10.37 0.38 2.07e-23 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg13256891 chr4:100009986 ADH5 -0.53 -9.85 -0.36 2.13e-21 Alcohol dependence; BRCA cis rs751728 0.717 rs3763258 chr6:33773744 A/G cg25922239 chr6:33757077 LEMD2 0.51 11.42 0.41 1.24e-27 Crohn's disease; BRCA cis rs9467773 1.000 rs12526680 chr6:26550954 A/G cg11502198 chr6:26597334 ABT1 0.47 9.46 0.35 5.7e-20 Intelligence (multi-trait analysis); BRCA cis rs2235642 0.821 rs2281236 chr16:1603576 G/A cg09065629 chr16:1709722 CRAMP1L 0.36 8.36 0.31 3.8e-16 Coronary artery disease; BRCA cis rs7587476 0.784 rs17424051 chr2:215688992 G/C cg04004882 chr2:215674386 BARD1 0.67 12.38 0.44 1.02e-31 Neuroblastoma; BRCA cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg18904891 chr8:8559673 CLDN23 0.61 11.98 0.43 5.44e-30 Obesity-related traits; BRCA cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg05072100 chr8:143858499 LYNX1 -0.41 -8.73 -0.33 2.14e-17 Urinary tract infection frequency; BRCA trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg03929089 chr4:120376271 NA 0.59 10.1 0.37 2.29e-22 Acute lymphoblastic leukemia (childhood); BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.54 -0.32 9.62e-17 Total body bone mineral density; BRCA cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg18876405 chr7:65276391 NA -0.63 -15.65 -0.53 5.9e-47 Aortic root size; BRCA cis rs4722585 0.605 rs10268883 chr7:26200417 C/T cg07876897 chr7:26191696 NFE2L3 0.43 9.33 0.35 1.71e-19 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs6121246 1.000 rs6121246 chr20:30433352 C/T cg21427119 chr20:30132790 HM13 -0.43 -9.24 -0.34 3.68e-19 Mean corpuscular hemoglobin; BRCA cis rs2404602 0.575 rs11072611 chr15:76947983 A/G cg23625390 chr15:77176239 SCAPER 0.56 12.94 0.46 3.66e-34 Blood metabolite levels; BRCA cis rs4074536 0.574 rs10801976 chr1:116295519 A/C cg21648376 chr1:116311395 CASQ2 -0.5 -8.73 -0.33 2.19e-17 QRS duration; BRCA cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg06026331 chr20:60912101 LAMA5 0.43 8.22 0.31 1.12e-15 Colorectal cancer; BRCA cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg03433033 chr1:76189801 ACADM -0.6 -12.13 -0.43 1.23e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs476633 0.691 rs28735224 chr15:41537539 C/T cg18705301 chr15:41695430 NDUFAF1 -0.4 -8.8 -0.33 1.32e-17 Glomerular filtration rate (creatinine); BRCA cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg06212747 chr3:49208901 KLHDC8B 0.51 8.0 0.3 5.96e-15 Menarche (age at onset); BRCA cis rs7131987 0.650 rs7301398 chr12:29455390 G/T cg09582351 chr12:29534625 ERGIC2 -0.46 -10.61 -0.39 2.46e-24 QT interval; BRCA cis rs4363385 0.669 rs4845519 chr1:153003916 G/T cg24667326 chr1:152973720 SPRR3 0.33 9.45 0.35 6.5e-20 Inflammatory skin disease; BRCA cis rs1499614 1.000 rs2707840 chr7:66158015 C/T cg18252515 chr7:66147081 NA -1.06 -15.69 -0.53 3.74e-47 Gout; BRCA cis rs4308124 0.708 rs56693625 chr2:111965155 G/A cg04571233 chr2:111982156 NA -0.45 -9.67 -0.36 9.81e-21 Vitiligo; BRCA cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg15017067 chr4:17643749 FAM184B 0.34 10.39 0.38 1.76e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg07741184 chr6:167504864 NA 0.29 8.37 0.31 3.57e-16 Crohn's disease; BRCA cis rs2710642 0.962 rs7567923 chr2:63085848 C/T cg17519650 chr2:63277830 OTX1 -0.38 -8.72 -0.33 2.47e-17 LDL cholesterol levels;LDL cholesterol; BRCA cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg06697600 chr4:7070879 GRPEL1 0.61 10.75 0.39 6.57e-25 Monocyte percentage of white cells; BRCA cis rs4953076 0.573 rs7593987 chr2:44393532 C/T cg04920474 chr2:44395004 PPM1B -0.47 -9.54 -0.35 3.04e-20 Height; BRCA cis rs6878727 0.850 rs988410 chr5:123730530 C/T cg01806427 chr5:123737813 NA 0.42 9.55 0.35 2.73e-20 Breast cancer; BRCA cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg08885076 chr2:99613938 TSGA10 0.43 10.31 0.38 3.72e-23 Chronic sinus infection; BRCA cis rs936229 0.954 rs936230 chr15:75145098 C/T cg14664628 chr15:75095509 CSK 0.83 21.87 0.65 1.39e-79 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs4074536 0.574 rs10754356 chr1:116292469 C/T cg21648376 chr1:116311395 CASQ2 0.48 8.52 0.32 1.11e-16 QRS duration; BRCA cis rs10267417 0.657 rs12668709 chr7:19858946 T/G cg07541023 chr7:19748670 TWISTNB 0.51 9.11 0.34 1.05e-18 Night sleep phenotypes; BRCA trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21659725 chr3:3221576 CRBN -0.71 -21.61 -0.65 3.69e-78 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg08888203 chr3:10149979 C3orf24 0.67 14.48 0.5 2.56e-41 Alzheimer's disease; BRCA cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg23711669 chr6:146136114 FBXO30 0.69 16.07 0.54 4.52e-49 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs13153245 chr5:93374891 G/A cg21475434 chr5:93447410 FAM172A 0.67 8.75 0.33 1.9e-17 Diabetic retinopathy; BRCA cis rs7474896 0.616 rs2505239 chr10:38440765 A/G cg25427524 chr10:38739819 LOC399744 -0.59 -10.15 -0.37 1.49e-22 Obesity (extreme); BRCA cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.23 0.41 7.53e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2147904 0.934 rs812487 chr1:42366198 G/A cg16685388 chr1:42384056 HIVEP3 0.32 9.08 0.34 1.36e-18 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 19.71 0.61 6.07e-68 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6545883 0.965 rs3771258 chr2:61764140 C/T cg15711740 chr2:61764176 XPO1 -0.56 -14.32 -0.49 1.52e-40 Tuberculosis; BRCA cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg16931447 chr4:875861 GAK -0.37 -8.43 -0.32 2.24e-16 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; BRCA cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.76 -0.33 1.79e-17 Colorectal cancer; BRCA cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg24642439 chr20:33292090 TP53INP2 -0.43 -8.79 -0.33 1.34e-17 Glomerular filtration rate (creatinine); BRCA cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg05340658 chr4:99064831 C4orf37 0.67 16.6 0.55 1.05e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs6688613 0.694 rs2075946 chr1:166818566 A/G ch.1.3259774R chr1:166827647 TADA1 0.42 8.97 0.33 3.39e-18 Refractive astigmatism; BRCA cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg20203395 chr5:56204925 C5orf35 -0.49 -10.25 -0.38 6.14e-23 Initial pursuit acceleration; BRCA cis rs17270561 0.609 rs1317816 chr6:25765390 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA trans rs7647973 0.626 rs11130217 chr3:49737323 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.7 -0.33 2.83e-17 Menarche (age at onset); BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg23358479 chr7:1110784 C7orf50 -0.49 -8.2 -0.31 1.27e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3815308 0.530 rs12983546 chr19:2195065 G/T cg09261902 chr19:2140048 AP3D1 0.35 8.55 0.32 8.99e-17 Breast cancer; BRCA cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.14 0.34 8.49e-19 Bladder cancer; BRCA cis rs7707921 0.881 rs60733727 chr5:81448283 G/A cg15871215 chr5:81402204 ATG10 -0.41 -8.59 -0.32 6.64e-17 Breast cancer; BRCA cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.1 0.31 2.81e-15 Bipolar disorder; BRCA cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.64 -0.5 4.62e-42 Chronic sinus infection; BRCA cis rs34779708 0.966 rs11010095 chr10:35395948 A/G cg03585969 chr10:35415529 CREM 0.44 9.26 0.34 3.1e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -8.63 -0.32 4.87e-17 Tonsillectomy; BRCA cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg15103426 chr22:29168792 CCDC117 0.51 11.88 0.43 1.43e-29 Lymphocyte counts; BRCA trans rs11098499 0.954 rs10518331 chr4:120323595 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.89e-15 Corneal astigmatism; BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26314531 chr2:26401878 FAM59B 0.85 13.83 0.48 2.92e-38 Gut microbiome composition (summer); BRCA cis rs6878727 0.614 rs256614 chr5:123660784 T/C cg01806427 chr5:123737813 NA -0.35 -7.94 -0.3 9.27e-15 Breast cancer; BRCA cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg16586182 chr3:47516702 SCAP 0.61 13.73 0.48 9.12e-38 Colorectal cancer; BRCA cis rs9400271 0.632 rs9384704 chr6:109587209 C/T cg01475377 chr6:109611718 NA -0.43 -10.24 -0.38 6.9e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg20476274 chr7:133979776 SLC35B4 0.63 17.75 0.57 1.4e-57 Mean platelet volume; BRCA cis rs708547 0.599 rs1718864 chr4:57887471 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.79 0.36 3.44e-21 Response to bleomycin (chromatid breaks); BRCA cis rs204247 0.565 rs411094 chr6:13718264 C/A cg02206980 chr6:13574034 SIRT5 -0.34 -9.5 -0.35 4.2e-20 Breast cancer; BRCA trans rs208520 0.526 rs9354370 chr6:66808209 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.12 38.9 0.84 1.2e-170 Exhaled nitric oxide output; BRCA cis rs908922 0.676 rs10888494 chr1:152514709 T/C cg20991723 chr1:152506922 NA 0.39 8.94 0.33 4.28e-18 Hair morphology; BRCA cis rs61863818 0.709 rs10786343 chr10:99159465 C/A cg08345082 chr10:99160200 RRP12 -0.31 -9.07 -0.34 1.46e-18 Monocyte percentage of white cells; BRCA trans rs11577318 0.853 rs4333841 chr1:26631927 T/C cg07461501 chr17:79650226 HGS;ARL16 0.4 10.11 0.37 2.14e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs35661897 0.920 rs12463838 chr2:227310093 G/A cg03426602 chr2:227312417 NA -0.47 -7.98 -0.3 6.63e-15 Urinary tract infection frequency; BRCA cis rs7927771 0.524 rs2290851 chr11:47753370 C/T cg20307385 chr11:47447363 PSMC3 -0.41 -9.7 -0.36 7.83e-21 Subjective well-being; BRCA cis rs11098499 0.955 rs7684942 chr4:120162201 C/T cg09307838 chr4:120376055 NA 0.61 12.31 0.44 2.09e-31 Corneal astigmatism; BRCA cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg08999081 chr20:33150536 PIGU -0.45 -12.47 -0.44 4.39e-32 Glomerular filtration rate (creatinine); BRCA cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg16102102 chr5:83017553 HAPLN1 -0.91 -17.84 -0.58 4.48e-58 Prostate cancer; BRCA cis rs11971779 0.715 rs6954219 chr7:139065110 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.21 0.37 9.03e-23 Diisocyanate-induced asthma; BRCA cis rs7072216 0.770 rs3830020 chr10:100176615 C/G cg26618903 chr10:100175079 PYROXD2 0.26 7.91 0.3 1.1e-14 Metabolite levels; BRCA cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg05340658 chr4:99064831 C4orf37 0.68 17.05 0.56 5.48e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg00106254 chr7:1943704 MAD1L1 -0.38 -9.02 -0.34 2.09e-18 Bipolar disorder and schizophrenia; BRCA cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg03433033 chr1:76189801 ACADM 0.76 17.51 0.57 2.43e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg18252515 chr7:66147081 NA -0.68 -10.93 -0.4 1.3e-25 Diabetic kidney disease; BRCA cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.67 -14.13 -0.49 1.2e-39 Personality dimensions; BRCA cis rs57590327 0.555 rs13072957 chr3:81776242 A/G cg07356753 chr3:81810745 GBE1 0.47 11.11 0.4 2.4e-26 Extraversion; BRCA cis rs4891159 0.548 rs617823 chr18:74120233 A/G cg24786174 chr18:74118243 ZNF516 0.83 25.25 0.71 4.36e-98 Longevity; BRCA cis rs7520050 0.966 rs12411269 chr1:46271052 C/T cg24296786 chr1:45957014 TESK2 0.44 9.96 0.37 8.03e-22 Red blood cell count;Reticulocyte count; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -10.98 -0.4 8.03e-26 Alzheimer's disease; BRCA cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg01028140 chr2:1542097 TPO -0.77 -15.31 -0.52 2.73e-45 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg12016809 chr21:47604291 C21orf56 0.4 7.94 0.3 9.19e-15 Testicular germ cell tumor; BRCA cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg25358565 chr5:93447407 FAM172A 1.23 18.97 0.6 5.63e-64 Diabetic retinopathy; BRCA cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.44 -0.35 6.68e-20 Body mass index; BRCA trans rs208520 1.000 rs72884033 chr6:66995747 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.39 0.49 7.25e-41 Exhaled nitric oxide output; BRCA cis rs4819052 0.634 rs8128636 chr21:46690633 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.47 10.16 0.37 1.45e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4074536 0.536 rs12140550 chr1:116291025 G/A cg21648376 chr1:116311395 CASQ2 -0.49 -8.68 -0.32 3.19e-17 QRS duration; BRCA cis rs796364 0.906 rs281784 chr2:200749749 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.8 0.42 3.22e-29 Schizophrenia; BRCA cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11890956 chr21:40555474 PSMG1 0.64 14.71 0.5 2.11e-42 Menarche (age at onset); BRCA cis rs9325144 0.600 rs10748442 chr12:38732939 A/T cg26384229 chr12:38710491 ALG10B 0.47 12.21 0.44 5.61e-31 Morning vs. evening chronotype; BRCA cis rs7523050 0.643 rs67567504 chr1:109402580 C/A cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg17420585 chr12:42539391 GXYLT1 -0.38 -8.08 -0.3 3.3e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg17971929 chr21:40555470 PSMG1 -0.49 -10.91 -0.4 1.5e-25 Menarche (age at onset); BRCA cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg02297831 chr4:17616191 MED28 0.39 9.11 0.34 1.08e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg10811474 chr19:8428787 ANGPTL4 -0.33 -8.35 -0.31 4.15e-16 HDL cholesterol; BRCA cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.54 11.06 0.4 3.74e-26 Monocyte percentage of white cells; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg16405210 chr4:1374714 KIAA1530 -0.53 -12.45 -0.44 5.43e-32 Longevity; BRCA cis rs698833 0.819 rs2340809 chr2:44536249 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.78 0.36 3.93e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg26769984 chr7:1090371 C7orf50 0.48 9.11 0.34 1.06e-18 Bronchopulmonary dysplasia; BRCA cis rs17401966 0.931 rs912961 chr1:10356848 A/G cg03954927 chr1:10346856 KIF1B 0.47 14.91 0.51 2.22e-43 Hepatocellular carcinoma; BRCA cis rs4561483 0.801 rs33660 chr16:11961858 A/G cg08843971 chr16:11963173 GSPT1 -0.51 -11.6 -0.42 2.24e-28 Testicular germ cell tumor; BRCA cis rs7011049 1.000 rs79536146 chr8:53853526 G/A cg26025543 chr8:53854495 NA 0.55 9.54 0.35 3.03e-20 Systolic blood pressure; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg15112475 chr7:1198522 ZFAND2A -0.61 -15.79 -0.53 1.14e-47 Longevity;Endometriosis; BRCA cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.91 -0.3 1.17e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs6952808 0.895 rs12669518 chr7:1921429 G/C cg04565464 chr8:145669602 NFKBIL2 0.37 8.7 0.33 2.73e-17 Bipolar disorder and schizophrenia; BRCA cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg11663144 chr21:46675770 NA -0.48 -9.81 -0.36 3.08e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs1039664 chr7:65449716 T/G cg18252515 chr7:66147081 NA -0.86 -12.34 -0.44 1.55e-31 Diabetic kidney disease; BRCA trans rs783540 0.934 rs7182403 chr15:83297613 C/T cg18393722 chr15:85113863 UBE2QP1 -0.28 -8.91 -0.33 5.42e-18 Schizophrenia; BRCA cis rs4742903 0.967 rs7048372 chr9:106859738 T/C cg14250997 chr9:106856677 SMC2 0.34 10.67 0.39 1.48e-24 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg04733989 chr22:42467013 NAGA -0.36 -8.03 -0.3 4.67e-15 Cognitive function; BRCA cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg04034577 chr2:241836375 C2orf54 -0.56 -13.46 -0.47 1.51e-36 Urinary metabolites; BRCA cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14240646 chr10:27532245 ACBD5 -0.72 -16.04 -0.54 6.32e-49 Breast cancer; BRCA cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.96 -0.3 7.61e-15 Prostate cancer; BRCA cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg05313129 chr8:58192883 C8orf71 -0.46 -9.17 -0.34 6.37e-19 Developmental language disorder (linguistic errors); BRCA cis rs7944584 0.551 rs12224672 chr11:47500400 C/T cg20307385 chr11:47447363 PSMC3 0.76 16.8 0.55 1.04e-52 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg03264133 chr6:25882463 NA -0.53 -11.93 -0.43 9.61e-30 Blood metabolite levels; BRCA cis rs6138458 0.887 rs227622 chr20:24910597 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.38 -0.31 3.34e-16 Blood protein levels; BRCA cis rs79976124 0.842 rs74881738 chr6:66621825 T/G cg07460842 chr6:66804631 NA 0.6 10.43 0.38 1.26e-23 Type 2 diabetes; BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 14.17 0.49 8.02e-40 Colorectal cancer; BRCA cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg06627628 chr2:24431161 ITSN2 -0.54 -8.81 -0.33 1.15e-17 Lymphocyte counts; BRCA cis rs7119 0.717 rs35268067 chr15:77753688 C/G cg17802220 chr15:77601643 NA -0.46 -10.18 -0.37 1.15e-22 Type 2 diabetes; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg21248554 chr2:27665150 KRTCAP3 -0.34 -8.69 -0.33 3.02e-17 Total body bone mineral density; BRCA cis rs2243480 1.000 rs34974928 chr7:65364006 T/C cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg23625390 chr15:77176239 SCAPER -0.36 -8.7 -0.33 2.91e-17 Blood metabolite levels; BRCA cis rs61931739 0.534 rs12372557 chr12:34363843 C/T cg06521331 chr12:34319734 NA -0.56 -10.01 -0.37 5.05e-22 Morning vs. evening chronotype; BRCA cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -14.44 -0.5 4.25e-41 Cognitive function; BRCA cis rs6878727 0.626 rs256857 chr5:123659824 T/C cg01806427 chr5:123737813 NA -0.36 -8.05 -0.3 4.04e-15 Breast cancer; BRCA cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.89 0.36 1.54e-21 Bladder cancer; BRCA cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg21770322 chr7:97807741 LMTK2 0.44 11.53 0.41 4.52e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 19.86 0.62 9.53e-69 Platelet count; BRCA cis rs6867032 1.000 rs2129471 chr5:2016236 C/G cg26168224 chr5:2018326 NA 0.64 17.82 0.58 6.05e-58 Gut microbiome composition (winter); BRCA cis rs4302748 0.862 rs57854543 chr7:36184158 C/G cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23221052 chr5:179740743 GFPT2 -0.64 -13.42 -0.47 2.44e-36 Height; BRCA cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg11062466 chr8:58055876 NA 0.42 8.1 0.31 2.86e-15 Developmental language disorder (linguistic errors); BRCA cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg13902645 chr11:5959945 NA -0.54 -11.11 -0.4 2.37e-26 DNA methylation (variation); BRCA cis rs372883 0.532 rs425989 chr21:30715275 T/C cg08807101 chr21:30365312 RNF160 -0.36 -8.18 -0.31 1.48e-15 Pancreatic cancer; BRCA cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg05283184 chr6:79620031 NA -0.43 -11.03 -0.4 4.97e-26 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg21573476 chr21:45109991 RRP1B -0.35 -8.82 -0.33 1.1e-17 Mean corpuscular volume; BRCA cis rs17270561 0.609 rs9358878 chr6:25740273 C/T cg16482183 chr6:26056742 HIST1H1C 0.47 8.94 0.33 4.11e-18 Iron status biomarkers; BRCA cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.41 -0.32 2.62e-16 Aortic root size; BRCA cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.17 -0.31 1.6e-15 Depression; BRCA cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg08000102 chr2:233561755 GIGYF2 0.62 13.57 0.47 4.67e-37 Coronary artery disease; BRCA cis rs881375 0.967 rs10435843 chr9:123668033 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.53 0.32 1.09e-16 Rheumatoid arthritis; BRCA cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg01475377 chr6:109611718 NA -0.44 -10.99 -0.4 7.28e-26 Reticulocyte fraction of red cells; BRCA cis rs6901250 0.568 rs4946198 chr6:117176599 C/T cg12892004 chr6:117198278 RFX6 -0.44 -8.89 -0.33 6.11e-18 C-reactive protein levels; BRCA cis rs17433780 0.612 rs7911 chr1:89518120 A/G cg26827852 chr1:89887630 LOC400759 0.33 7.98 0.3 6.65e-15 Carotid intima media thickness; BRCA cis rs3820928 0.874 rs59630650 chr2:227786514 T/C cg11843606 chr2:227700838 RHBDD1 -0.41 -9.01 -0.34 2.39e-18 Pulmonary function; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.22 -0.46 1.99e-35 Platelet count; BRCA cis rs17685 0.753 rs11972240 chr7:75694079 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.56 -0.32 8.61e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg12935359 chr14:103987150 CKB -0.52 -11.26 -0.41 6e-27 Intelligence (multi-trait analysis); BRCA cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg24562669 chr7:97807699 LMTK2 0.6 17.59 0.57 8.38e-57 Breast cancer; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg18404041 chr3:52824283 ITIH1 -0.32 -9.65 -0.36 1.16e-20 Bipolar disorder; BRCA cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.26 -0.34 3.04e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs28735056 0.620 rs12456484 chr18:77677315 C/G cg20368463 chr18:77673604 PQLC1 0.49 12.34 0.44 1.57e-31 Schizophrenia; BRCA cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg13256891 chr4:100009986 ADH5 0.52 9.77 0.36 4.15e-21 Alcohol dependence; BRCA cis rs7617773 0.817 rs13100815 chr3:48287449 A/C cg11946769 chr3:48343235 NME6 0.67 13.67 0.48 1.72e-37 Coronary artery disease; BRCA cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg13319975 chr6:146136371 FBXO30 0.45 10.38 0.38 1.97e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg24803719 chr17:45855879 NA -0.33 -8.48 -0.32 1.53e-16 IgG glycosylation; BRCA cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg02297831 chr4:17616191 MED28 0.34 7.88 0.3 1.41e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7927771 1.000 rs10838757 chr11:47763016 T/C cg18512352 chr11:47633146 NA -0.33 -8.15 -0.31 1.94e-15 Subjective well-being; BRCA cis rs9914988 0.887 rs4795463 chr17:27146389 G/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.81 -0.33 1.13e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs847577 0.508 rs12538837 chr7:97684468 C/T cg21770322 chr7:97807741 LMTK2 0.36 8.28 0.31 7.44e-16 Breast cancer; BRCA cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg01939980 chr4:1354348 KIAA1530 0.29 8.11 0.31 2.67e-15 Longevity; BRCA cis rs2336384 1.000 rs7551874 chr1:12048130 A/G cg13216073 chr1:12042593 MFN2 0.44 9.55 0.35 2.6e-20 Platelet count; BRCA cis rs17376456 0.597 rs11135401 chr5:93365716 G/A cg25358565 chr5:93447407 FAM172A -0.52 -9.41 -0.35 8.75e-20 Diabetic retinopathy; BRCA trans rs3857536 0.740 rs7773577 chr6:66892124 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg27165867 chr14:105738592 BRF1 -0.36 -8.74 -0.33 2.01e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.98 -0.62 2.26e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.67 0.55 4.69e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs4268898 0.697 rs10445892 chr2:24406958 T/C cg06627628 chr2:24431161 ITSN2 0.45 9.43 0.35 7.53e-20 Asthma; BRCA cis rs7220401 0.512 rs2289629 chr17:27959903 A/G cg26525008 chr17:28256777 EFCAB5;SSH2 0.49 10.52 0.38 5.63e-24 Coronary artery disease; BRCA cis rs561341 0.556 rs542244 chr17:30307242 T/C cg00745463 chr17:30367425 LRRC37B -0.52 -8.8 -0.33 1.26e-17 Hip circumference adjusted for BMI; BRCA cis rs5758659 0.652 rs5758537 chr22:42397042 G/T cg15557168 chr22:42548783 NA -0.32 -8.81 -0.33 1.16e-17 Cognitive function; BRCA cis rs6546550 0.867 rs4852349 chr2:70076954 A/T cg02498382 chr2:70120550 SNRNP27 -0.5 -10.37 -0.38 2.16e-23 Prevalent atrial fibrillation; BRCA cis rs2797160 1.000 rs1739373 chr6:126011509 A/G cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.19e-20 Endometrial cancer; BRCA cis rs6840360 0.615 rs10021407 chr4:152465002 A/G cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 9.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.774 rs162404 chr21:44963264 G/A cg04455712 chr21:45112962 RRP1B 0.41 10.7 0.39 1.05e-24 Mean corpuscular volume; BRCA cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs829883 0.664 rs829874 chr12:98840615 G/A cg25150519 chr12:98850993 NA 0.67 16.16 0.54 1.57e-49 Colorectal adenoma (advanced); BRCA cis rs7178424 1.000 rs12913951 chr15:62372592 A/G cg00456672 chr15:62358751 C2CD4A -0.36 -8.66 -0.32 3.81e-17 Height; BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg00106254 chr7:1943704 MAD1L1 -0.36 -9.51 -0.35 3.8e-20 Bipolar disorder and schizophrenia; BRCA cis rs495337 0.760 rs1056200 chr20:48556248 A/G cg17835207 chr20:48524531 SPATA2 -0.69 -16.83 -0.55 6.76e-53 Psoriasis; BRCA cis rs11098499 0.863 rs10018280 chr4:120478139 T/G cg09307838 chr4:120376055 NA 0.69 14.89 0.51 2.79e-43 Corneal astigmatism; BRCA cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg09658497 chr7:2847517 GNA12 0.39 8.31 0.31 5.54e-16 Height; BRCA cis rs7809615 0.901 rs10808111 chr7:99070884 T/A cg12290671 chr7:99195819 NA -0.5 -8.59 -0.32 6.77e-17 Blood metabolite ratios; BRCA cis rs600806 0.888 rs6695482 chr1:109870859 C/G cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.5e-15 Intelligence (multi-trait analysis); BRCA cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg06636001 chr8:8085503 FLJ10661 0.7 15.81 0.53 8.86e-48 Mood instability; BRCA cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg16179182 chr5:140090404 VTRNA1-1 0.47 10.99 0.4 7.61e-26 Depressive symptoms (multi-trait analysis); BRCA cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.72 -0.36 6.63e-21 Body mass index; BRCA trans rs2665103 0.632 rs3902959 chr15:82544927 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.32 -8.69 -0.33 3.06e-17 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg25214090 chr10:38739885 LOC399744 0.57 12.99 0.46 2.06e-34 Corneal astigmatism; BRCA trans rs4332037 0.522 rs4721098 chr7:1881527 G/C cg11693508 chr17:37793320 STARD3 -0.59 -11.12 -0.4 2.17e-26 Bipolar disorder; BRCA cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.47 0.35 5.16e-20 Tonsillectomy; BRCA cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs60012524 1 rs60012524 chr2:99559117 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -12.96 -0.46 2.89e-34 Chronic sinus infection; BRCA cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg13319975 chr6:146136371 FBXO30 0.42 9.6 0.36 1.74e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg18351406 chr4:77819688 ANKRD56 0.58 12.6 0.45 1.14e-32 Emphysema distribution in smoking; BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00166722 chr3:10149974 C3orf24 0.65 11.29 0.41 4.52e-27 Alzheimer's disease; BRCA cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg11752832 chr7:134001865 SLC35B4 0.53 13.81 0.48 3.87e-38 Mean platelet volume; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg03188948 chr7:1209495 NA 0.62 12.76 0.45 2.34e-33 Longevity;Endometriosis; BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.1 -0.43 1.65e-30 Gut microbiome composition (summer); BRCA cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.09 0.4 2.94e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9486719 0.843 rs2103539 chr6:96844342 T/A cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg12935359 chr14:103987150 CKB -0.59 -14.09 -0.49 1.85e-39 Body mass index; BRCA trans rs11098499 0.566 rs17051356 chr4:120585308 C/T cg25214090 chr10:38739885 LOC399744 0.5 10.34 0.38 2.83e-23 Corneal astigmatism; BRCA cis rs4481887 0.962 rs10788768 chr1:248456027 G/A cg00666640 chr1:248458726 OR2T12 0.33 8.66 0.32 3.76e-17 Common traits (Other); BRCA cis rs12579753 0.789 rs35448307 chr12:82165817 A/G cg07988820 chr12:82153109 PPFIA2 -0.63 -10.63 -0.39 2.01e-24 Resting heart rate; BRCA cis rs561341 1.000 rs561341 chr17:30316385 T/G cg00745463 chr17:30367425 LRRC37B -0.53 -8.91 -0.33 5.45e-18 Hip circumference adjusted for BMI; BRCA cis rs875971 0.929 rs778712 chr7:65849978 C/T cg11764359 chr7:65958608 NA 0.8 19.64 0.61 1.58e-67 Aortic root size; BRCA cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.48 0.47 1.21e-36 Colorectal cancer; BRCA cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg08999081 chr20:33150536 PIGU 0.47 13.04 0.46 1.28e-34 Glomerular filtration rate (creatinine); BRCA cis rs10751667 0.600 rs11246377 chr11:999796 G/T cg06064525 chr11:970664 AP2A2 -0.27 -8.06 -0.3 3.65e-15 Alzheimer's disease (late onset); BRCA cis rs9341808 0.718 rs3828754 chr6:80900640 C/G cg08355045 chr6:80787529 NA 0.39 9.96 0.37 7.9e-22 Sitting height ratio; BRCA cis rs9359856 0.564 rs72915933 chr6:90441464 C/T cg13799429 chr6:90582589 CASP8AP2 -0.67 -8.43 -0.32 2.28e-16 Bipolar disorder; BRCA cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg11764359 chr7:65958608 NA 0.8 19.35 0.61 5.5000000000000005e-66 Aortic root size; BRCA cis rs68170813 0.559 rs6971675 chr7:106833797 G/A cg02696742 chr7:106810147 HBP1 -0.52 -8.35 -0.31 4.12e-16 Coronary artery disease; BRCA cis rs7617773 0.817 rs6796490 chr3:48237104 A/C cg11946769 chr3:48343235 NME6 0.49 11.28 0.41 4.77e-27 Coronary artery disease; BRCA cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg08885076 chr2:99613938 TSGA10 -0.57 -12.88 -0.45 6.45e-34 Chronic sinus infection; BRCA cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg02466173 chr16:30829666 NA 0.5 11.31 0.41 3.75e-27 Dementia with Lewy bodies; BRCA cis rs7914558 1.000 rs4917996 chr10:104925829 A/C cg04362960 chr10:104952993 NT5C2 0.43 10.38 0.38 1.93e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg10556349 chr10:835070 NA 0.73 9.85 0.36 2.13e-21 Eosinophil percentage of granulocytes; BRCA trans rs1941687 0.527 rs2000945 chr18:31365336 A/G cg27147174 chr7:100797783 AP1S1 -0.52 -10.49 -0.38 7.33e-24 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg11887960 chr12:57824829 NA 0.53 8.26 0.31 8.2e-16 Lung disease severity in cystic fibrosis; BRCA cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -8.6 -0.32 6.06e-17 Personality dimensions; BRCA cis rs1065852 0.526 rs2097562 chr22:42389500 T/C cg22189786 chr22:42395067 WBP2NL 0.41 8.39 0.32 3.1e-16 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs6450176 1.000 rs59061738 chr5:53296557 A/G ch.5.1024479R chr5:53302184 ARL15 -0.63 -14.96 -0.51 1.31e-43 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs4285028 0.851 rs1986368 chr3:121710969 A/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.69 -0.39 1.14e-24 Multiple sclerosis; BRCA cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg17509989 chr5:176798049 RGS14 -0.75 -11.8 -0.42 3.35e-29 Urate levels in lean individuals; BRCA cis rs72772090 0.539 rs11738115 chr5:96113072 A/T cg17330273 chr5:96107758 CAST;ERAP1 0.57 11.68 0.42 1.1e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs11098499 0.863 rs7664986 chr4:120429952 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.13 0.31 2.16e-15 Corneal astigmatism; BRCA cis rs877282 0.947 rs7923867 chr10:768094 G/A cg17470449 chr10:769945 NA 0.49 8.47 0.32 1.72e-16 Uric acid levels; BRCA cis rs11764590 0.724 rs62444917 chr7:2107262 A/C cg23422044 chr7:1970798 MAD1L1 -0.43 -8.87 -0.33 7.36e-18 Neuroticism; BRCA cis rs7179456 0.545 rs507801 chr15:59053345 T/G cg05156742 chr15:59063176 FAM63B 0.46 9.22 0.34 4.11e-19 Asperger disorder; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 9.67 0.36 9.57e-21 Bipolar disorder; BRCA cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg10295955 chr4:187884368 NA 0.96 27.99 0.74 3.86e-113 Lobe attachment (rater-scored or self-reported); BRCA cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg19729930 chr2:74357872 NA 0.63 14.74 0.5 1.45e-42 Gestational age at birth (maternal effect); BRCA trans rs877282 0.947 rs957642 chr10:773966 C/T cg22713356 chr15:30763199 NA 1.15 23.14 0.68 1.7e-86 Uric acid levels; BRCA cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.06 0.46 1.02e-34 Bipolar disorder; BRCA cis rs12474201 0.928 rs12999586 chr2:46938736 C/T cg06386533 chr2:46925753 SOCS5 0.87 18.83 0.6 3.16e-63 Height; BRCA trans rs7618501 0.699 rs2681781 chr3:49898273 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.37 10.22 0.37 8.54e-23 Intelligence (multi-trait analysis); BRCA cis rs9341808 0.700 rs12215236 chr6:80975058 A/T cg08355045 chr6:80787529 NA 0.37 9.56 0.35 2.58e-20 Sitting height ratio; BRCA cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg21138405 chr5:131827807 IRF1 0.4 12.98 0.46 2.4e-34 Asthma (sex interaction); BRCA trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg03929089 chr4:120376271 NA 0.49 7.98 0.3 6.92e-15 D-dimer levels; BRCA cis rs1401999 0.690 rs6768149 chr3:183636195 T/C cg20387954 chr3:183756860 HTR3D 0.39 8.87 0.33 6.99e-18 Anterior chamber depth; BRCA cis rs12541635 0.677 rs1817939 chr8:107029820 A/G cg10147462 chr8:107024639 NA 0.39 10.56 0.39 3.85e-24 Age of smoking initiation; BRCA cis rs2070997 0.607 rs2855191 chr9:133708441 C/T cg11464064 chr9:133710261 ABL1 -0.54 -10.01 -0.37 5.12e-22 Response to amphetamines; BRCA cis rs367943 1.000 rs348930 chr5:112814763 T/C cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg10253484 chr15:75165896 SCAMP2 -0.56 -11.7 -0.42 8.59e-29 Breast cancer; BRCA cis rs6089584 0.566 rs6061401 chr20:60607482 G/A cg13770153 chr20:60521292 NA -0.38 -9.02 -0.34 2.15e-18 Body mass index; BRCA cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg12365402 chr11:9010492 NRIP3 -0.37 -8.45 -0.32 1.9e-16 Hemoglobin concentration; BRCA cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.34 0.31 4.57e-16 Cognitive ability; BRCA cis rs897984 0.609 rs732172 chr16:31050033 C/T cg02466173 chr16:30829666 NA -0.44 -9.85 -0.36 2.08e-21 Dementia with Lewy bodies; BRCA cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.33 0.31 4.83e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg11663144 chr21:46675770 NA -0.48 -9.62 -0.36 1.45e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1568889 0.712 rs4567438 chr11:28380051 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.52 9.72 0.36 6.56e-21 Bipolar disorder; BRCA cis rs9653442 0.704 rs10211595 chr2:100726476 G/C cg22139774 chr2:100720529 AFF3 -0.29 -8.21 -0.31 1.18e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg12935359 chr14:103987150 CKB -0.61 -13.9 -0.48 1.51e-38 Intelligence (multi-trait analysis); BRCA trans rs17685 0.753 rs10245584 chr7:75745866 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 27.8 0.74 4.4e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs877282 0.898 rs12356709 chr10:763365 A/G cg17470449 chr10:769945 NA 0.47 7.92 0.3 1.08e-14 Uric acid levels; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg08470875 chr2:26401718 FAM59B 0.72 10.32 0.38 3.51e-23 Gut microbiome composition (summer); BRCA cis rs1003719 0.591 rs2018521 chr21:38517264 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.56 -12.48 -0.44 3.95e-32 Eye color traits; BRCA cis rs12950390 0.853 rs8078052 chr17:45859434 A/G cg03474202 chr17:45855739 NA -0.46 -12.21 -0.43 5.72e-31 IgG glycosylation; BRCA cis rs1048238 0.506 rs7525608 chr1:16141901 A/G cg21385522 chr1:16154831 NA 0.46 9.86 0.36 1.89e-21 Systolic blood pressure; BRCA cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs1451375 1.000 rs10250513 chr7:50621488 T/G cg18232548 chr7:50535776 DDC 0.43 10.09 0.37 2.54e-22 Malaria; BRCA cis rs9318086 0.935 rs9553083 chr13:24441525 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.29 -8.33 -0.31 4.79e-16 Myopia (pathological); BRCA cis rs2070488 0.965 rs35553573 chr3:38441439 C/T cg24069376 chr3:38537580 EXOG 0.39 11.12 0.4 2.26e-26 Electrocardiographic conduction measures; BRCA cis rs9875589 0.509 rs2731330 chr3:14111588 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.95 0.33 3.7e-18 Ovarian reserve; BRCA cis rs7246657 0.943 rs35540940 chr19:38008235 G/A cg18154014 chr19:37997991 ZNF793 0.63 12.27 0.44 3.28e-31 Coronary artery calcification; BRCA cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg11764359 chr7:65958608 NA -0.76 -17.64 -0.57 4.74e-57 Aortic root size; BRCA cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg05283184 chr6:79620031 NA -0.43 -11.01 -0.4 6.1e-26 Intelligence (multi-trait analysis); BRCA cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs9858542 0.537 rs35869135 chr3:49359102 A/G cg00383909 chr3:49044727 WDR6 0.48 9.66 0.36 1.03e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs3768617 0.510 rs1886499 chr1:183095024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs3125734 0.572 rs3864794 chr10:64041956 A/C cg19640130 chr10:64028056 RTKN2 -0.33 -9.14 -0.34 8.48e-19 Rheumatoid arthritis; BRCA cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.72 0.36 6.67e-21 Bipolar disorder; BRCA cis rs6684514 0.922 rs2075166 chr1:156215562 G/A cg16558208 chr1:156270281 VHLL 0.36 7.88 0.3 1.42e-14 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg05707623 chr12:122985044 ZCCHC8 0.5 9.65 0.36 1.15e-20 Body mass index; BRCA cis rs6963495 0.818 rs818619 chr7:105172505 A/T cg19920283 chr7:105172520 RINT1 0.65 12.98 0.46 2.34e-34 Bipolar disorder (body mass index interaction); BRCA cis rs3845702 0.736 rs3845701 chr2:180826781 A/G cg01881094 chr2:180872142 CWC22 -0.96 -17.49 -0.57 2.83e-56 Schizophrenia; BRCA cis rs6840360 0.533 rs13147021 chr4:152722688 A/C cg22705602 chr4:152727874 NA 0.39 10.42 0.38 1.41e-23 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg12923728 chr3:195709715 SDHAP1 -0.59 -12.57 -0.45 1.55e-32 Pancreatic cancer; BRCA cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg19346786 chr7:2764209 NA -0.32 -9.77 -0.36 3.99e-21 Height; BRCA cis rs733175 0.951 rs7669090 chr4:10028131 C/T cg00071950 chr4:10020882 SLC2A9 0.41 7.97 0.3 7.25e-15 Psychosis and Alzheimer's disease; BRCA cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg24692254 chr21:30365293 RNF160 0.66 18.2 0.58 5.71e-60 Dental caries; BRCA cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg00071950 chr4:10020882 SLC2A9 0.64 16.26 0.54 5.02e-50 Bone mineral density; BRCA cis rs870825 0.929 rs56106324 chr4:185589901 C/A cg04058563 chr4:185651563 MLF1IP 0.69 11.72 0.42 7.1e-29 Blood protein levels; BRCA cis rs62064224 0.553 rs9915115 chr17:30684858 A/G cg25809561 chr17:30822961 MYO1D 0.39 9.05 0.34 1.67e-18 Schizophrenia; BRCA cis rs61931739 0.534 rs10844840 chr12:34364517 C/T cg06521331 chr12:34319734 NA -0.56 -10.02 -0.37 4.62e-22 Morning vs. evening chronotype; BRCA trans rs11098499 0.909 rs28793658 chr4:120307214 A/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs736408 0.608 rs4687657 chr3:52852538 G/T cg18404041 chr3:52824283 ITIH1 -0.38 -10.37 -0.38 2.14e-23 Bipolar disorder; BRCA cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg23788917 chr6:8435910 SLC35B3 -0.47 -10.18 -0.37 1.22e-22 Motion sickness; BRCA cis rs832540 0.898 rs331497 chr5:56251660 G/T cg24531977 chr5:56204891 C5orf35 0.39 8.16 0.31 1.73e-15 Coronary artery disease; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg24846343 chr22:24311635 DDTL -0.56 -14.17 -0.49 7.73e-40 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24110177 chr3:50126178 RBM5 0.38 10.57 0.39 3.54e-24 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg06494592 chr3:125709126 NA -0.53 -8.25 -0.31 9.2e-16 Blood pressure (smoking interaction); BRCA cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.85 0.45 8.63e-34 Electroencephalogram traits; BRCA cis rs752010 0.967 rs6703597 chr1:42097904 C/T cg06885757 chr1:42089581 HIVEP3 0.24 8.64 0.32 4.39e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs10463316 0.894 rs6579863 chr5:150761946 A/T cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg23711669 chr6:146136114 FBXO30 0.75 17.17 0.56 1.3e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs11690935 1.000 rs11678984 chr2:172535848 T/G cg13550731 chr2:172543902 DYNC1I2 0.94 32.12 0.79 1.73e-135 Schizophrenia; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg23285459 chr7:2802560 GNA12 -0.35 -8.83 -0.33 9.77e-18 Height; BRCA cis rs490234 0.902 rs10739662 chr9:128278687 T/C cg14078157 chr9:128172775 NA -0.33 -7.87 -0.3 1.55e-14 Mean arterial pressure; BRCA cis rs6433895 1.000 rs59395276 chr2:182020696 T/C cg00481216 chr2:181971175 NA 0.38 8.78 0.33 1.55e-17 Lymphocyte counts; BRCA cis rs2070488 0.965 rs7372849 chr3:38524328 G/C cg24069376 chr3:38537580 EXOG 0.39 11.4 0.41 1.53e-27 Electrocardiographic conduction measures; BRCA trans rs8073060 0.544 rs225268 chr17:33966224 A/C cg19694781 chr19:47549865 TMEM160 -1.06 -21.58 -0.65 5.04e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs4780401 0.728 rs7188511 chr16:11773743 G/T cg01061890 chr16:11836724 TXNDC11 -0.44 -9.73 -0.36 5.68e-21 Rheumatoid arthritis; BRCA cis rs72781680 0.848 rs6754694 chr2:24155448 T/C cg08917208 chr2:24149416 ATAD2B 0.94 13.85 0.48 2.55e-38 Lymphocyte counts; BRCA cis rs870825 0.616 rs7680779 chr4:185652830 G/C cg04058563 chr4:185651563 MLF1IP -0.73 -15.84 -0.53 6.2e-48 Blood protein levels; BRCA cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg20701182 chr2:24300061 SF3B14 0.67 9.77 0.36 4.1e-21 Lymphocyte counts; BRCA cis rs1451375 0.572 rs745042 chr7:50544138 A/G cg18232548 chr7:50535776 DDC -0.41 -8.7 -0.33 2.8e-17 Malaria; BRCA cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.53 11.41 0.41 1.4e-27 Colorectal cancer; BRCA cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.6 -0.32 6.05e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08109568 chr15:31115862 NA -0.45 -10.6 -0.39 2.77e-24 Huntington's disease progression; BRCA cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.28 -0.31 7.24e-16 Aortic root size; BRCA cis rs9790314 0.580 rs960212 chr3:161047974 C/T cg04691961 chr3:161091175 C3orf57 -0.4 -9.33 -0.35 1.65e-19 Morning vs. evening chronotype; BRCA cis rs738322 0.967 rs133017 chr22:38572637 A/C cg25457927 chr22:38595422 NA -0.32 -11.89 -0.43 1.38e-29 Cutaneous nevi; BRCA cis rs6952407 1 rs6952407 chr7:66045512 A/G cg11764359 chr7:65958608 NA -0.68 -15.2 -0.52 9.03e-45 Cotinine glucuronidation; BRCA cis rs11971779 0.680 rs66491565 chr7:139088977 C/G cg07862535 chr7:139043722 LUC7L2 0.4 10.97 0.4 9.39e-26 Diisocyanate-induced asthma; BRCA cis rs6088813 0.961 rs6060371 chr20:33913322 G/T cg14752227 chr20:34000481 UQCC 0.4 8.4 0.32 2.96e-16 Height; BRCA cis rs796364 0.694 rs1653299 chr2:201075611 A/G cg23649088 chr2:200775458 C2orf69 0.59 11.9 0.43 1.22e-29 Schizophrenia; BRCA trans rs75804782 0.572 rs112551758 chr2:239299770 A/G cg01134436 chr17:81009848 B3GNTL1 0.74 7.88 0.3 1.38e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.4 -9.75 -0.36 4.86e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs875971 1.000 rs778696 chr7:65870813 C/G cg18876405 chr7:65276391 NA 0.55 13.35 0.47 4.99e-36 Aortic root size; BRCA cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg11266682 chr4:10021025 SLC2A9 0.49 13.12 0.46 5.22e-35 Bone mineral density; BRCA cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg05890377 chr2:74357713 NA 0.46 11.74 0.42 5.94e-29 Gestational age at birth (maternal effect); BRCA trans rs62103177 0.525 rs4799117 chr18:77756604 G/A cg05926928 chr17:57297772 GDPD1 -0.59 -9.1 -0.34 1.13e-18 Opioid sensitivity; BRCA cis rs7903847 0.642 rs11189179 chr10:99143320 T/C cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2180341 0.566 rs982306 chr6:127777039 T/C cg24812749 chr6:127587940 RNF146 0.6 13.07 0.46 8.88e-35 Breast cancer; BRCA cis rs4074536 0.548 rs9887923 chr1:116288224 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg11366901 chr6:160182831 ACAT2 0.81 15.96 0.53 1.75e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs7560272 0.512 rs13015885 chr2:73920482 G/T cg20560298 chr2:73613845 ALMS1 0.35 9.13 0.34 8.62e-19 Schizophrenia; BRCA cis rs4845570 1.000 rs11586946 chr1:151769806 G/A cg07092448 chr1:151763213 TDRKH -0.9 -16.07 -0.54 4.64e-49 Coronary artery disease; BRCA cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15541040 chr2:3486749 NA -0.42 -9.15 -0.34 7.34e-19 Neurofibrillary tangles; BRCA cis rs36051895 0.632 rs12352022 chr9:5161836 T/G cg02405213 chr9:5042618 JAK2 -0.48 -8.89 -0.33 6.14e-18 Pediatric autoimmune diseases; BRCA cis rs12541635 0.677 rs55639043 chr8:107055993 C/T cg10147462 chr8:107024639 NA 0.4 10.89 0.4 1.88e-25 Age of smoking initiation; BRCA cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg03264133 chr6:25882463 NA -0.53 -11.95 -0.43 7.44e-30 Blood metabolite levels; BRCA cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg06212747 chr3:49208901 KLHDC8B 0.55 12.15 0.43 1.01e-30 Menarche (age at onset); BRCA cis rs12579753 0.810 rs10862355 chr12:82162698 C/T cg07988820 chr12:82153109 PPFIA2 -0.6 -11.04 -0.4 4.5e-26 Resting heart rate; BRCA trans rs35110281 0.633 rs4819289 chr21:45120237 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.43 0.32 2.3e-16 Mean corpuscular volume; BRCA cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 12.57 0.45 1.57e-32 Personality dimensions; BRCA cis rs9815354 0.812 rs73073229 chr3:42007850 T/C cg03022575 chr3:42003672 ULK4 0.74 10.27 0.38 5.43e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg26647111 chr11:31128758 NA -0.45 -9.78 -0.36 3.99e-21 Red blood cell count; BRCA cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg25173405 chr17:45401733 C17orf57 0.48 10.01 0.37 5.23e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9296092 0.538 rs56199698 chr6:33534505 G/C cg13560919 chr6:33536144 NA -0.91 -19.42 -0.61 2.12e-66 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs721399 0.924 rs1115784 chr8:18255410 C/T cg18736775 chr8:18248649 NAT2 0.39 8.44 0.32 2.15e-16 Blood metabolite levels; BRCA cis rs10779751 0.770 rs10864490 chr1:11236410 A/C cg08854313 chr1:11322531 MTOR 0.76 15.62 0.53 8.33e-47 Body mass index; BRCA cis rs11955398 0.625 rs10939857 chr5:59956801 C/T cg02684056 chr5:59996105 DEPDC1B 0.38 8.84 0.33 9.1e-18 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.620 rs708143 chr12:33719962 A/C cg26384229 chr12:38710491 ALG10B 0.41 9.28 0.34 2.69e-19 Morning vs. evening chronotype; BRCA cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg02659138 chr7:134003124 SLC35B4 0.34 10.71 0.39 9.67e-25 Mean platelet volume; BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg08470875 chr2:26401718 FAM59B -0.52 -8.28 -0.31 7.21e-16 Gut microbiome composition (summer); BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg03354898 chr7:1950403 MAD1L1 -0.58 -13.91 -0.48 1.32e-38 Bipolar disorder and schizophrenia; BRCA cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg13298116 chr11:62369859 EML3;MTA2 0.57 13.17 0.46 3.31e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg04166393 chr7:2884313 GNA12 0.41 8.99 0.34 2.76e-18 Height; BRCA cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.3 -0.31 6.2e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs495337 0.699 rs2982414 chr20:48463058 A/G cg17835207 chr20:48524531 SPATA2 -0.5 -10.83 -0.39 3.33e-25 Psoriasis; BRCA cis rs870825 0.929 rs72689266 chr4:185591053 T/C cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs2191566 0.576 rs419839 chr19:44495598 C/T cg20607764 chr19:44506953 ZNF230 0.37 8.02 0.3 5.01e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg25204440 chr1:209979598 IRF6 0.51 13.79 0.48 4.84e-38 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs1401999 1.000 rs4148571 chr3:183720576 A/C cg01324343 chr3:183735012 ABCC5 0.83 21.18 0.64 8.04e-76 Anterior chamber depth; BRCA cis rs887829 0.569 rs3806596 chr2:234637707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.33 8.5 0.32 1.36e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs4919087 0.810 rs10786321 chr10:99026112 T/C cg25902810 chr10:99078978 FRAT1 0.41 8.99 0.34 2.69e-18 Monocyte count; BRCA cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.42e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4363385 0.818 rs370162 chr1:153005488 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs7301016 0.793 rs11174557 chr12:62979216 C/T cg01804193 chr12:63026212 NA 0.46 8.36 0.31 3.91e-16 IgG glycosylation; BRCA cis rs7727544 0.582 rs3805681 chr5:131537860 T/G cg14196790 chr5:131705035 SLC22A5 0.36 9.08 0.34 1.29e-18 Blood metabolite levels; BRCA cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg23711669 chr6:146136114 FBXO30 -0.8 -19.38 -0.61 3.73e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg04455712 chr21:45112962 RRP1B 0.46 11.34 0.41 2.85e-27 Mean corpuscular volume; BRCA cis rs295140 0.506 rs295136 chr2:201141002 G/C cg23649088 chr2:200775458 C2orf69 0.4 8.39 0.32 3.08e-16 QT interval; BRCA cis rs10927875 0.541 rs1739843 chr1:16343254 T/C cg22431228 chr1:16359049 CLCNKA -0.44 -9.82 -0.36 2.75e-21 Dilated cardiomyopathy; BRCA cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08109568 chr15:31115862 NA -0.43 -10.26 -0.38 6.01e-23 Huntington's disease progression; BRCA cis rs9814567 0.964 rs9841180 chr3:134191880 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.23 -0.31 1.09e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10911232 0.507 rs4266836 chr1:183029070 T/G ch.1.3577855R chr1:183094577 LAMC1 0.62 16.12 0.54 2.76e-49 Hypertriglyceridemia; BRCA cis rs11098499 0.866 rs6847778 chr4:120293582 A/G cg09307838 chr4:120376055 NA 0.68 14.64 0.5 4.72e-42 Corneal astigmatism; BRCA trans rs4596713 0.508 rs4076287 chr9:71755333 A/G cg16512924 chr15:28394682 HERC2 0.42 10.03 0.37 4.51e-22 Headache; BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -10.14 -0.37 1.7e-22 Alzheimer's disease; BRCA cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg11301795 chr4:187892539 NA 0.31 10.69 0.39 1.15e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg04944784 chr2:26401820 FAM59B 0.97 15.01 0.51 7.4e-44 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg08470875 chr2:26401718 FAM59B -0.76 -11.6 -0.42 2.24e-28 Gut microbiome composition (summer); BRCA cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg13271783 chr10:134563150 INPP5A -0.5 -9.57 -0.35 2.31e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2486288 0.586 rs12909625 chr15:45572053 C/A cg15395560 chr15:45543142 SLC28A2 0.29 7.95 0.3 8.65e-15 Glomerular filtration rate; BRCA cis rs7147624 0.683 rs8017258 chr14:66231017 C/G cg03016385 chr14:66212404 NA 0.55 7.98 0.3 6.74e-15 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg24642439 chr20:33292090 TP53INP2 0.38 7.88 0.3 1.39e-14 Height; BRCA cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg13271783 chr10:134563150 INPP5A -0.35 -7.94 -0.3 9.19e-15 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.09 -0.4 2.84e-26 Lymphocyte counts; BRCA cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg11266682 chr4:10021025 SLC2A9 0.46 12.21 0.43 5.95e-31 Bone mineral density; BRCA cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg22875332 chr1:76189707 ACADM -0.51 -9.8 -0.36 3.24e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg00701064 chr4:6280414 WFS1 0.62 14.26 0.49 2.83e-40 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7927771 0.756 rs2856661 chr11:47374998 A/G cg20307385 chr11:47447363 PSMC3 0.4 8.22 0.31 1.14e-15 Subjective well-being; BRCA cis rs3815700 1.000 rs10404211 chr19:33093565 C/T cg02997394 chr19:33096574 ANKRD27 0.61 8.65 0.32 4.04e-17 Eosinophilic esophagitis; BRCA cis rs427394 0.659 rs274675 chr5:6755319 C/T cg10857441 chr5:6722123 POLS -0.32 -10.02 -0.37 4.87e-22 Menopause (age at onset); BRCA cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.09 -0.3 2.95e-15 Depression; BRCA cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg12935359 chr14:103987150 CKB -0.6 -13.53 -0.47 7.47e-37 Intelligence (multi-trait analysis); BRCA cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.5e-36 High light scatter reticulocyte count; BRCA cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg20891283 chr12:69753455 YEATS4 0.37 8.84 0.33 8.93e-18 Blood protein levels; BRCA cis rs6500602 0.673 rs4786513 chr16:4576423 T/C cg08645402 chr16:4508243 NA 0.41 9.86 0.36 1.94e-21 Schizophrenia; BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg27446573 chr6:127587934 RNF146 0.54 12.09 0.43 1.86e-30 Breast cancer; BRCA cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg20503657 chr10:835505 NA 1.03 15.66 0.53 5.34e-47 Eosinophil percentage of granulocytes; BRCA cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg11189052 chr15:85197271 WDR73 0.44 9.05 0.34 1.66e-18 Schizophrenia; BRCA cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg25036284 chr2:26402008 FAM59B 0.94 13.89 0.48 1.53e-38 Gut microbiome composition (summer); BRCA cis rs9325144 0.555 rs1813392 chr12:38692203 C/T cg13010199 chr12:38710504 ALG10B -0.36 -8.51 -0.32 1.21e-16 Morning vs. evening chronotype; BRCA trans rs11098499 0.909 rs35111518 chr4:120440682 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.34 0.31 4.72e-16 Corneal astigmatism; BRCA cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -11.92 -0.43 1.02e-29 Personality dimensions; BRCA cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.64e-24 Motion sickness; BRCA cis rs4481887 0.962 rs10788769 chr1:248457426 C/T cg13385794 chr1:248469461 NA 0.29 7.88 0.3 1.44e-14 Common traits (Other); BRCA trans rs208520 0.661 rs4710566 chr6:66848538 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.95 -0.64 1.37e-74 Exhaled nitric oxide output; BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13732083 chr21:47605072 C21orf56 0.38 7.85 0.3 1.75e-14 Testicular germ cell tumor; BRCA cis rs561341 1.000 rs530209 chr17:30315287 A/G cg00745463 chr17:30367425 LRRC37B -0.53 -8.91 -0.33 5.45e-18 Hip circumference adjusted for BMI; BRCA cis rs1448094 0.512 rs7133591 chr12:86239752 G/C cg19622623 chr12:86230825 RASSF9 -0.32 -8.98 -0.33 3e-18 Major depressive disorder; BRCA cis rs6582630 0.559 rs12318620 chr12:38522340 T/C cg26384229 chr12:38710491 ALG10B -0.45 -10.6 -0.39 2.73e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.505 rs12826314 chr12:39379435 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs7737355 0.947 rs6859469 chr5:130962546 C/T cg06307176 chr5:131281290 NA 0.52 10.11 0.37 2.1e-22 Life satisfaction; BRCA cis rs9463078 0.764 rs9369513 chr6:44789476 T/C cg25276700 chr6:44698697 NA -0.36 -8.42 -0.32 2.41e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg11301795 chr4:187892539 NA -0.28 -9.24 -0.34 3.54e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443189 0.570 rs9341532 chr6:76403674 A/G cg01950844 chr6:76311363 SENP6 0.84 13.53 0.47 7.52e-37 Prostate cancer; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg22920501 chr2:26401640 FAM59B 0.94 16.16 0.54 1.61e-49 Gut microbiome composition (summer); BRCA cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg11764359 chr7:65958608 NA -0.75 -16.9 -0.56 2.91e-53 Aortic root size; BRCA cis rs7520050 0.966 rs1707336 chr1:46493460 T/G cg24296786 chr1:45957014 TESK2 0.43 9.59 0.35 1.9e-20 Red blood cell count;Reticulocyte count; BRCA cis rs9880211 0.948 rs34135127 chr3:136226498 T/C cg21827317 chr3:136751795 NA -0.44 -7.87 -0.3 1.52e-14 Body mass index;Height; BRCA cis rs9814567 1.000 rs7619451 chr3:134233238 A/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.35 -8.03 -0.3 4.73e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs6582630 0.502 rs11610978 chr12:38356957 C/G cg06521331 chr12:34319734 NA -0.47 -8.99 -0.34 2.71e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg23422044 chr7:1970798 MAD1L1 -0.59 -10.85 -0.39 2.67e-25 Bipolar disorder; BRCA cis rs208520 0.802 rs851600 chr6:66893754 T/C cg07460842 chr6:66804631 NA -0.93 -16.92 -0.56 2.38e-53 Exhaled nitric oxide output; BRCA cis rs7737355 0.947 rs12656936 chr5:130788642 A/C cg06307176 chr5:131281290 NA -0.53 -10.55 -0.39 4.22e-24 Life satisfaction; BRCA cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.78 -0.58 9.4e-58 Chronic sinus infection; BRCA cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.09 0.43 1.83e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs9399135 0.967 rs9389253 chr6:135329755 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.41 0.44 8.05e-32 Red blood cell count; BRCA cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg01819863 chr10:32635814 EPC1 1.15 20.31 0.63 3.9e-71 Sexual dysfunction (female); BRCA cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg25358565 chr5:93447407 FAM172A 1.19 18.82 0.6 3.54e-63 Diabetic retinopathy; BRCA cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg05347473 chr6:146136440 FBXO30 0.42 8.39 0.32 3.1e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs9325144 0.600 rs12424410 chr12:38758035 A/T cg23762105 chr12:34175262 ALG10 0.36 8.49 0.32 1.45e-16 Morning vs. evening chronotype; BRCA cis rs17685 0.753 rs3757593 chr7:75678735 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.4 8.99 0.33 2.89e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4363385 0.747 rs2879489 chr1:152970465 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.88 -0.33 6.69e-18 Inflammatory skin disease; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg10862848 chr6:42927986 GNMT -0.34 -14.49 -0.5 2.36e-41 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9359856 0.529 rs56352205 chr6:90439272 C/T cg13799429 chr6:90582589 CASP8AP2 -0.71 -8.58 -0.32 7.04e-17 Bipolar disorder; BRCA cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg26647111 chr11:31128758 NA -0.42 -9.35 -0.35 1.47e-19 Red blood cell count; BRCA cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg09184832 chr6:79620586 NA -0.53 -11.69 -0.42 9.67e-29 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg08219700 chr8:58056026 NA 0.59 9.82 0.36 2.69e-21 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.965 rs7421663 chr2:61753786 C/T cg15711740 chr2:61764176 XPO1 -0.55 -14.2 -0.49 5.44e-40 Tuberculosis; BRCA cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.05 0.49 2.87e-39 Motion sickness; BRCA cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg25358565 chr5:93447407 FAM172A 1.22 19.53 0.61 5.73e-67 Diabetic retinopathy; BRCA cis rs2425143 1.000 rs8116836 chr20:34453362 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.47 -0.35 5.22e-20 Blood protein levels; BRCA trans rs629535 0.748 rs689410 chr8:70037558 G/A cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.22e-26 Bipolar disorder; BRCA cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg20476274 chr7:133979776 SLC35B4 0.6 14.74 0.5 1.56e-42 Mean platelet volume; BRCA cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.17 0.43 8.34e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26119090 chr2:26468346 HADHA;HADHB 1.05 21.9 0.65 9.95e-80 Gut microbiome composition (summer); BRCA cis rs796364 0.616 rs2103094 chr2:200687954 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.34 0.31 4.49e-16 Schizophrenia; BRCA cis rs6088813 1.000 rs224329 chr20:34019579 C/T cg14752227 chr20:34000481 UQCC 0.38 8.05 0.3 3.97e-15 Height; BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.49 -8.79 -0.33 1.37e-17 Renal function-related traits (BUN); BRCA cis rs12541635 0.677 rs6999580 chr8:107018254 C/T cg10147462 chr8:107024639 NA 0.38 10.36 0.38 2.32e-23 Age of smoking initiation; BRCA cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg05283184 chr6:79620031 NA -0.43 -11.0 -0.4 6.58e-26 Intelligence (multi-trait analysis); BRCA cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg27446573 chr6:127587934 RNF146 0.89 20.5 0.63 3.86e-72 Breast cancer; BRCA cis rs61612642 0.537 rs73434275 chr6:42156239 G/A cg01092361 chr6:42185687 MRPS10 0.69 11.89 0.43 1.38e-29 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg08807892 chr2:162101083 NA 0.51 10.1 0.37 2.35e-22 Intelligence (multi-trait analysis); BRCA cis rs9486715 0.867 rs9486181 chr6:96868132 G/A cg06623918 chr6:96969491 KIAA0776 0.9 25.43 0.71 4.24e-99 Headache; BRCA cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA trans rs2204008 0.837 rs11612125 chr12:38213212 C/T cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg24812749 chr6:127587940 RNF146 -0.91 -20.9 -0.64 2.5e-74 Breast cancer; BRCA cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg18512352 chr11:47633146 NA 0.32 8.02 0.3 4.99e-15 Subjective well-being; BRCA cis rs9487051 0.698 rs9374081 chr6:109631782 A/G cg01475377 chr6:109611718 NA -0.44 -9.51 -0.35 3.76e-20 Reticulocyte fraction of red cells; BRCA cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg22875332 chr1:76189707 ACADM 0.81 19.7 0.61 7.26e-68 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg08885076 chr2:99613938 TSGA10 -0.46 -8.65 -0.32 4.1e-17 Chronic sinus infection; BRCA cis rs8014204 1.000 rs8014374 chr14:75322914 G/A cg06637938 chr14:75390232 RPS6KL1 -0.59 -11.84 -0.42 2.28e-29 Caffeine consumption; BRCA trans rs6479891 1.000 rs2393980 chr10:65224510 C/G cg14819942 chr15:35414228 NA 0.35 8.59 0.32 6.62e-17 Arthritis (juvenile idiopathic); BRCA cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg06115741 chr20:33292138 TP53INP2 0.39 8.62 0.32 5.23e-17 Glomerular filtration rate (creatinine); BRCA cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg06064525 chr11:970664 AP2A2 -0.48 -16.22 -0.54 8.78e-50 Alzheimer's disease (late onset); BRCA cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg08085267 chr17:45401833 C17orf57 0.69 15.36 0.52 1.56e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs79387448 0.638 rs11465670 chr2:103034440 A/G cg09003973 chr2:102972529 NA 0.52 8.0 0.3 6.07e-15 Gut microbiota (bacterial taxa); BRCA trans rs35110281 0.667 rs2250773 chr21:45087786 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.23 0.31 1.05e-15 Mean corpuscular volume; BRCA cis rs7707921 0.881 rs111907176 chr5:81312399 A/G cg15871215 chr5:81402204 ATG10 -0.4 -8.39 -0.31 3.21e-16 Breast cancer; BRCA cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg06627628 chr2:24431161 ITSN2 -0.56 -9.05 -0.34 1.69e-18 Lymphocyte counts; BRCA cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.82 0.42 2.66e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -16.9 -0.56 3.01e-53 Extrinsic epigenetic age acceleration; BRCA cis rs16958440 1.000 rs57928699 chr18:44645593 T/A cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs832540 1.000 rs192249 chr5:56197514 C/G cg18230493 chr5:56204884 C5orf35 -0.42 -8.55 -0.32 9.31e-17 Coronary artery disease; BRCA cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14442939 chr10:27389572 ANKRD26 0.66 10.99 0.4 7.61e-26 Breast cancer; BRCA cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.79 0.39 4.73e-25 Mean corpuscular volume; BRCA cis rs9517320 0.534 rs4771306 chr13:99143661 T/C cg07423050 chr13:99094983 FARP1 -0.49 -11.01 -0.4 5.94e-26 Longevity; BRCA cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg22455342 chr2:225449267 CUL3 0.65 17.04 0.56 5.88e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg20607287 chr7:12443886 VWDE -0.58 -8.19 -0.31 1.46e-15 Coronary artery disease; BRCA cis rs113835537 0.529 rs75003264 chr11:66256099 G/A cg24851651 chr11:66362959 CCS 0.5 8.69 0.32 3.12e-17 Airway imaging phenotypes; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg03354898 chr7:1950403 MAD1L1 -0.47 -9.47 -0.35 5.51e-20 Bipolar disorder and schizophrenia; BRCA cis rs35146811 0.735 rs6948729 chr7:99787372 A/G cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.03 0.37 4.25e-22 Bipolar disorder; BRCA cis rs6840360 0.571 rs1822347 chr4:152525319 A/G cg22705602 chr4:152727874 NA -0.32 -8.31 -0.31 5.88e-16 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg26384229 chr12:38710491 ALG10B 0.77 17.41 0.57 7.15e-56 Bladder cancer; BRCA cis rs3768617 0.528 rs2027082 chr1:183084608 C/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.72 0.57 1.98e-57 Fuchs's corneal dystrophy; BRCA cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.64 -0.32 4.36e-17 Intelligence (multi-trait analysis); BRCA trans rs7786808 0.776 rs11983316 chr7:158209742 A/G cg02030672 chr11:45687055 CHST1 0.51 11.37 0.41 2.15e-27 Obesity-related traits; BRCA cis rs6582630 0.622 rs11182005 chr12:38441292 G/A cg26384229 chr12:38710491 ALG10B -0.43 -10.04 -0.37 4.13e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.545 rs12821810 chr12:39375858 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs7633770 0.786 rs1520489 chr3:46677519 A/G cg11219411 chr3:46661640 NA -0.64 -17.25 -0.56 5e-55 Coronary artery disease; BRCA cis rs11190604 1.000 rs11190551 chr10:102204734 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.42 0.41 1.25e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9640161 0.742 rs2108854 chr7:150017408 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 0.54 13.64 0.47 2.21e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 3.04e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg15017067 chr4:17643749 FAM184B 0.32 9.79 0.36 3.54e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2404602 0.684 rs12437981 chr15:76842401 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.96 -0.48 7.8e-39 Blood metabolite levels; BRCA trans rs1459104 1.000 rs35218816 chr11:55087104 C/A cg15704280 chr7:45808275 SEPT13 0.7 8.7 0.33 2.73e-17 Body mass index; BRCA cis rs9814567 1.000 rs6766897 chr3:134191303 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.31 -0.31 5.62e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11190604 0.767 rs10883489 chr10:102194532 T/C cg07080220 chr10:102295463 HIF1AN 0.44 9.78 0.36 3.68e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.53 12.07 0.43 2.21e-30 Colorectal cancer; BRCA trans rs7786808 0.504 rs10949725 chr7:158196003 C/T cg02030672 chr11:45687055 CHST1 -0.39 -8.9 -0.33 5.53e-18 Obesity-related traits; BRCA cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg20891558 chr2:74357851 NA -0.47 -10.28 -0.38 4.66e-23 Gestational age at birth (maternal effect); BRCA cis rs798554 0.591 rs757791 chr7:2867296 A/G cg04166393 chr7:2884313 GNA12 0.42 8.72 0.33 2.46e-17 Height; BRCA cis rs698833 0.926 rs1067367 chr2:44654905 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 10.02 0.37 4.87e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg08885076 chr2:99613938 TSGA10 -0.54 -12.53 -0.44 2.24e-32 Chronic sinus infection; BRCA cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg04727924 chr7:799746 HEATR2 -0.54 -10.27 -0.38 5.12e-23 Cerebrospinal P-tau181p levels; BRCA cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg24562669 chr7:97807699 LMTK2 -0.39 -10.53 -0.38 5.33e-24 Prostate cancer (SNP x SNP interaction); BRCA cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg13660082 chr14:53194042 PSMC6 -0.57 -8.13 -0.31 2.15e-15 Alzheimer's disease (late onset); BRCA cis rs16976116 0.901 rs28708989 chr15:55498934 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg04455712 chr21:45112962 RRP1B 0.4 10.47 0.38 8.8e-24 Mean corpuscular volume; BRCA cis rs28830936 1.000 rs12441300 chr15:42102845 A/G cg17847044 chr15:42102381 MAPKBP1 -0.36 -9.67 -0.36 1e-20 Diastolic blood pressure; BRCA cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.33 -10.56 -0.39 3.85e-24 Bipolar disorder; BRCA cis rs13095912 0.962 rs34505819 chr3:185340721 C/T cg11274856 chr3:185301563 NA 0.34 8.37 0.31 3.72e-16 Systolic blood pressure; BRCA cis rs858239 0.899 rs28458177 chr7:23294872 G/A cg23682824 chr7:23144976 KLHL7 0.32 8.18 0.31 1.54e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs117623576 0.941 rs16932939 chr10:32407862 T/C cg03047570 chr10:32398778 NA -0.59 -8.97 -0.33 3.31e-18 Anti-saccade response; BRCA cis rs2624839 0.704 rs12632110 chr3:50224225 A/G cg24110177 chr3:50126178 RBM5 0.41 11.24 0.41 6.84e-27 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.818 rs7688802 chr4:120451668 G/A cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg26597838 chr10:835615 NA 1.02 18.06 0.58 3.33e-59 Eosinophil percentage of granulocytes; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07308232 chr7:1071921 C7orf50 -0.42 -8.55 -0.32 9.4e-17 Longevity;Endometriosis; BRCA cis rs2859741 0.935 rs2782410 chr1:37509489 G/C cg09363841 chr1:37513479 NA -0.65 -16.02 -0.54 8e-49 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs9467773 0.595 rs3799379 chr6:26404694 C/T cg09904177 chr6:26538194 HMGN4 -0.36 -9.5 -0.35 4.14e-20 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.935 rs3757131 chr6:25783909 C/T cg03264133 chr6:25882463 NA 0.5 11.19 0.4 1.12e-26 Blood metabolite levels; BRCA cis rs250677 0.687 rs1422581 chr5:148437386 C/T cg23229984 chr5:148520753 ABLIM3 -0.35 -8.81 -0.33 1.2e-17 Breast cancer; BRCA cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg17971929 chr21:40555470 PSMG1 0.79 18.79 0.6 4.9e-63 Cognitive function; BRCA cis rs4742903 0.967 rs10125661 chr9:106868443 A/G cg21169611 chr9:106856078 SMC2 0.36 9.35 0.35 1.44e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg11833968 chr6:79620685 NA -0.39 -8.72 -0.33 2.33e-17 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.605 rs74632724 chr7:107136759 A/G cg02696742 chr7:106810147 HBP1 -0.5 -7.91 -0.3 1.17e-14 Coronary artery disease; BRCA cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg23711669 chr6:146136114 FBXO30 0.77 17.91 0.58 1.9e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7249921 0.833 rs7255878 chr19:35667192 C/T cg15419183 chr19:35660584 FXYD5 0.45 10.17 0.37 1.22e-22 Platelet count; BRCA cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg08000102 chr2:233561755 GIGYF2 -0.62 -13.55 -0.47 6.2e-37 Coronary artery disease; BRCA cis rs1215050 0.791 rs1025201 chr4:98902938 A/G cg05340658 chr4:99064831 C4orf37 -0.45 -10.26 -0.38 5.51e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.606 rs28481322 chr4:99086638 T/C cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 6.87e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg11752832 chr7:134001865 SLC35B4 0.5 11.62 0.42 1.86e-28 Mean platelet volume; BRCA cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg20503657 chr10:835505 NA 1.02 15.54 0.52 1.96e-46 Eosinophil percentage of granulocytes; BRCA cis rs6910061 0.956 rs61185321 chr6:11103103 T/G cg27233058 chr6:11094804 LOC221710 0.53 9.36 0.35 1.3e-19 Diabetic kidney disease; BRCA cis rs11229555 0.598 rs12276438 chr11:58185419 G/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.72e-31 Breast cancer; BRCA cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg17366294 chr4:99064904 C4orf37 0.41 9.22 0.34 4.31e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs7707921 1.000 rs17245188 chr5:81469082 A/C cg15871215 chr5:81402204 ATG10 0.4 8.35 0.31 4.21e-16 Breast cancer; BRCA cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg06552810 chr11:31128660 NA 0.41 8.92 0.33 4.71e-18 Red blood cell count; BRCA cis rs7772486 0.902 rs2748500 chr6:146314852 C/A cg23711669 chr6:146136114 FBXO30 0.63 14.52 0.5 1.67e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs3772130 0.924 rs55643643 chr3:121440197 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.13 0.34 9.23e-19 Cognitive performance; BRCA cis rs35306767 0.855 rs35825568 chr10:950760 C/T cg20503657 chr10:835505 NA 1.04 17.4 0.57 8.52e-56 Eosinophil percentage of granulocytes; BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg05457628 chr5:178986728 RUFY1 -0.5 -12.39 -0.44 9.85e-32 Lung cancer; BRCA cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg01017244 chr2:74357527 NA 0.52 12.29 0.44 2.49e-31 Gestational age at birth (maternal effect); BRCA cis rs4819052 0.679 rs2236450 chr21:46702553 T/C cg11663144 chr21:46675770 NA -0.47 -11.05 -0.4 4.46e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6920965 0.545 rs614031 chr6:126165720 A/C cg05901451 chr6:126070800 HEY2 -0.35 -8.62 -0.32 5.43e-17 High light scatter reticulocyte count; BRCA cis rs9790314 1.000 rs7653233 chr3:160992033 G/A cg03342759 chr3:160939853 NMD3 -0.64 -14.76 -0.5 1.21e-42 Morning vs. evening chronotype; BRCA cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg05555928 chr11:63887634 MACROD1 -0.44 -8.03 -0.3 4.61e-15 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg14983838 chr19:29218262 NA 0.54 10.03 0.37 4.44e-22 Methadone dose in opioid dependence; BRCA cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg06784218 chr1:46089804 CCDC17 0.49 11.91 0.43 1.16e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg17892150 chr10:133769511 PPP2R2D -0.72 -15.44 -0.52 6.07e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg24642439 chr20:33292090 TP53INP2 0.7 16.24 0.54 6.72e-50 Coronary artery disease; BRCA cis rs758324 0.947 rs13154286 chr5:131160189 A/G cg06307176 chr5:131281290 NA 0.52 10.16 0.37 1.42e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1165205 0.558 rs793144 chr6:25879321 C/T cg03264133 chr6:25882463 NA -0.82 -19.86 -0.62 9.97e-69 Urate levels; BRCA cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.58 11.73 0.42 6.62e-29 Hip circumference adjusted for BMI; BRCA cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg03517284 chr6:25882590 NA 0.43 8.89 0.33 6.13e-18 Intelligence (multi-trait analysis); BRCA cis rs6901250 1.000 rs993394 chr6:117117143 G/A cg12892004 chr6:117198278 RFX6 0.49 11.07 0.4 3.55e-26 C-reactive protein levels; BRCA cis rs7633857 0.512 rs10936215 chr3:160652271 A/G cg03342759 chr3:160939853 NMD3 -0.52 -10.96 -0.4 9.53e-26 Educational attainment (years of education); BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.98e-16 Total body bone mineral density; BRCA cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg17143192 chr8:8559678 CLDN23 0.55 10.43 0.38 1.27e-23 Obesity-related traits; BRCA cis rs61931739 0.500 rs11053277 chr12:34553835 T/A cg06521331 chr12:34319734 NA -0.52 -10.27 -0.38 5.25e-23 Morning vs. evening chronotype; BRCA cis rs9527 0.545 rs11191602 chr10:104954219 C/T cg04362960 chr10:104952993 NT5C2 0.43 9.75 0.36 4.83e-21 Arsenic metabolism; BRCA cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg24692254 chr21:30365293 RNF160 0.41 9.04 0.34 1.82e-18 Selective IgA deficiency; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg13397359 chr6:42928475 GNMT 0.67 16.1 0.54 3.13e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1691799 0.867 rs1168332 chr12:66761548 C/T cg16791601 chr12:66731901 HELB -0.66 -17.99 -0.58 7.53e-59 White blood cell count (basophil); BRCA cis rs7582180 0.614 rs1530030 chr2:101009600 G/A cg08017756 chr2:100939284 LONRF2 -0.3 -7.9 -0.3 1.22e-14 Intelligence (multi-trait analysis); BRCA cis rs10911251 0.546 rs3359 chr1:183112041 G/C ch.1.3577855R chr1:183094577 LAMC1 0.6 15.18 0.51 1.17e-44 Colorectal cancer; BRCA cis rs6973256 0.897 rs17601462 chr7:133347066 A/G cg07491979 chr7:133331646 EXOC4 -0.39 -8.94 -0.33 4.2e-18 Intelligence (multi-trait analysis); BRCA cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg11764359 chr7:65958608 NA -0.8 -19.12 -0.6 8.59e-65 Aortic root size; BRCA cis rs7072216 0.763 rs2274244 chr10:100175218 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 8.8e-21 Metabolite levels; BRCA cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg17330251 chr7:94953956 PON1 -0.42 -8.57 -0.32 7.92e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg01448562 chr3:133502909 NA 0.57 13.84 0.48 2.87e-38 Iron status biomarkers; BRCA cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg05564831 chr3:52568323 NT5DC2 0.34 8.11 0.31 2.54e-15 Electroencephalogram traits; BRCA cis rs2019216 0.500 rs6565385 chr17:21897646 C/A cg22648282 chr17:21454238 C17orf51 -0.4 -9.27 -0.34 2.93e-19 Pelvic organ prolapse; BRCA cis rs9399135 0.967 rs9402676 chr6:135355507 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.29 0.44 2.63e-31 Red blood cell count; BRCA cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.9 0.43 1.18e-29 Schizophrenia; BRCA cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.94 0.37 9.84e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2839186 0.681 rs13047198 chr21:47701835 T/C cg12516959 chr21:47718080 NA -0.35 -8.36 -0.31 3.99e-16 Testicular germ cell tumor; BRCA cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.24 0.34 3.66e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg26384229 chr12:38710491 ALG10B -0.82 -21.69 -0.65 1.36e-78 Heart rate; BRCA cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg05347473 chr6:146136440 FBXO30 -0.42 -8.41 -0.32 2.75e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg14835575 chr10:16859367 RSU1 0.63 14.06 0.49 2.53e-39 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg05340658 chr4:99064831 C4orf37 -0.56 -11.42 -0.41 1.23e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg17892150 chr10:133769511 PPP2R2D -0.73 -15.66 -0.53 4.96e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg11752832 chr7:134001865 SLC35B4 0.5 12.88 0.45 6.66e-34 Mean platelet volume; BRCA cis rs514406 0.505 rs395169 chr1:53174071 G/A cg24675658 chr1:53192096 ZYG11B -0.65 -14.33 -0.49 1.34e-40 Monocyte count; BRCA trans rs61931739 0.534 rs11053072 chr12:34202399 A/C cg26384229 chr12:38710491 ALG10B 0.67 14.29 0.49 2.1e-40 Morning vs. evening chronotype; BRCA cis rs11955398 0.501 rs10067618 chr5:60010995 G/A cg02684056 chr5:59996105 DEPDC1B -0.41 -9.65 -0.36 1.2e-20 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg24562669 chr7:97807699 LMTK2 0.47 12.58 0.45 1.38e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.862 rs778684 chr7:65836403 A/T cg11764359 chr7:65958608 NA 0.77 17.42 0.57 6.69e-56 Aortic root size; BRCA cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.23e-23 Motion sickness; BRCA cis rs17270561 0.666 rs4712971 chr6:25771900 T/C cg16482183 chr6:26056742 HIST1H1C 0.55 10.5 0.38 6.63e-24 Iron status biomarkers; BRCA trans rs8073060 0.586 rs4796100 chr17:33997657 G/T cg19694781 chr19:47549865 TMEM160 1.01 20.07 0.62 7.78e-70 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.52 -10.97 -0.4 9.27e-26 Lymphocyte counts; BRCA cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg03806693 chr22:41940476 POLR3H 0.97 18.76 0.6 6.57e-63 Vitiligo; BRCA cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg26343298 chr8:95960752 TP53INP1 0.29 8.3 0.31 6.38e-16 Type 2 diabetes; BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg08470875 chr2:26401718 FAM59B -0.63 -9.41 -0.35 8.56e-20 Gut microbiome composition (summer); BRCA trans rs561341 0.769 rs559228 chr17:30294527 T/C cg20587970 chr11:113659929 NA -1.2 -22.13 -0.66 5.45e-81 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg05340658 chr4:99064831 C4orf37 0.58 12.42 0.44 7.03e-32 Colonoscopy-negative controls vs population controls; BRCA trans rs3942852 0.606 rs10734561 chr11:48097480 C/T cg15704280 chr7:45808275 SEPT13 -0.44 -8.14 -0.31 2.1e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.17 -0.31 1.66e-15 Aortic root size; BRCA cis rs6459804 0.844 rs76501205 chr7:157508941 A/T cg05731713 chr7:157510257 PTPRN2 0.39 10.12 0.37 1.94e-22 Bipolar disorder and schizophrenia; BRCA cis rs7246657 0.722 rs1564208 chr19:38041221 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.1 0.34 1.1e-18 Coronary artery calcification; BRCA cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg04166393 chr7:2884313 GNA12 0.42 9.09 0.34 1.21e-18 Height; BRCA cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg11822812 chr5:140052017 DND1 -0.3 -8.1 -0.31 2.72e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg04025307 chr7:1156635 C7orf50 0.75 19.71 0.61 6.57e-68 Longevity;Endometriosis; BRCA cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg11663144 chr21:46675770 NA -0.6 -13.88 -0.48 1.75e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9469578 0.792 rs73743329 chr6:33713943 T/A cg18708504 chr6:33715942 IP6K3 0.7 10.18 0.37 1.12e-22 Phosphorus levels; BRCA cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg25019033 chr10:957182 NA -0.41 -7.89 -0.3 1.34e-14 Eosinophil percentage of granulocytes; BRCA cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg11752832 chr7:134001865 SLC35B4 0.53 13.72 0.48 9.45e-38 Mean platelet volume; BRCA cis rs651907 0.557 rs17347644 chr3:101547733 C/T cg12386194 chr3:101231763 SENP7 0.48 9.79 0.36 3.56e-21 Colorectal cancer; BRCA cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg14019146 chr3:50243930 SLC38A3 -0.34 -8.16 -0.31 1.84e-15 Intelligence (multi-trait analysis); BRCA trans rs7824557 0.767 rs11775635 chr8:11164865 G/A cg06636001 chr8:8085503 FLJ10661 0.53 10.04 0.37 3.92e-22 Retinal vascular caliber; BRCA cis rs9790314 0.934 rs462413 chr3:161101587 T/C cg03342759 chr3:160939853 NMD3 -0.64 -13.34 -0.47 5.56e-36 Morning vs. evening chronotype; BRCA cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 10.92 0.4 1.48e-25 Rheumatoid arthritis; BRCA cis rs2549003 0.966 rs839 chr5:131819126 C/T cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.5e-34 Asthma (sex interaction); BRCA cis rs7944584 0.632 rs11039159 chr11:47294021 G/T cg03711944 chr11:47377212 SPI1 -0.35 -7.83 -0.3 1.98e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1538970 0.816 rs11211123 chr1:45957609 G/A cg05343316 chr1:45956843 TESK2 0.7 14.57 0.5 1.02e-41 Platelet count; BRCA cis rs4919694 0.572 rs7080935 chr10:104929113 C/A cg04362960 chr10:104952993 NT5C2 0.71 12.33 0.44 1.66e-31 Arsenic metabolism; BRCA cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg20701182 chr2:24300061 SF3B14 0.63 8.97 0.33 3.35e-18 Lymphocyte counts; BRCA cis rs757081 0.637 rs34941502 chr11:17155432 G/A cg15432903 chr11:17409602 KCNJ11 -0.46 -8.66 -0.32 3.73e-17 Systolic blood pressure; BRCA cis rs9297145 0.585 rs10953283 chr7:98782750 A/G cg05967295 chr7:98741636 SMURF1 0.61 13.2 0.46 2.47e-35 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.45 -0.32 1.93e-16 Total body bone mineral density; BRCA cis rs1003719 0.762 rs2835598 chr21:38466669 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.12 0.49 1.35e-39 Eye color traits; BRCA cis rs7267979 0.966 rs2261794 chr20:25263062 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9790314 0.659 rs13066683 chr3:160847410 A/G cg03342759 chr3:160939853 NMD3 -0.5 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs2795502 0.882 rs2744091 chr10:43339441 A/G cg20628663 chr10:43360327 NA -0.69 -13.4 -0.47 2.99e-36 Blood protein levels; BRCA cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2637266 0.935 rs12772269 chr10:78394292 C/A cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg04756594 chr16:24857601 SLC5A11 -0.34 -8.32 -0.31 5.29e-16 Intelligence (multi-trait analysis); BRCA trans rs656319 0.629 rs10111315 chr8:9865588 G/A cg06636001 chr8:8085503 FLJ10661 -0.44 -9.07 -0.34 1.45e-18 Myopia (pathological); BRCA trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg03929089 chr4:120376271 NA -0.68 -13.52 -0.47 7.85e-37 Coronary artery disease; BRCA cis rs61931739 0.534 rs11052986 chr12:34052578 T/C cg06521331 chr12:34319734 NA -0.58 -11.65 -0.42 1.47e-28 Morning vs. evening chronotype; BRCA cis rs4595586 0.545 rs1375796 chr12:39410592 G/T cg26384229 chr12:38710491 ALG10B 0.54 11.51 0.41 5.36e-28 Morning vs. evening chronotype; BRCA trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21582582 chr3:182698605 DCUN1D1 -0.38 -10.1 -0.37 2.35e-22 Intelligence (multi-trait analysis); BRCA cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg14784868 chr12:69753453 YEATS4 0.45 11.64 0.42 1.48e-28 Blood protein levels; BRCA cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.722 rs954504 chr19:38045394 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.13 0.34 8.69e-19 Coronary artery calcification; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg21782813 chr7:2030301 MAD1L1 0.43 12.37 0.44 1.18e-31 Bipolar disorder and schizophrenia; BRCA cis rs7208859 0.673 rs2433 chr17:29226228 T/C cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg26384229 chr12:38710491 ALG10B 0.75 16.51 0.55 2.8e-51 Morning vs. evening chronotype; BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg16431978 chr21:31797932 KRTAP13-3 0.38 9.42 0.35 8.21e-20 HDL cholesterol; BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.76 0.67 2.09e-84 Platelet count; BRCA trans rs7829975 0.593 rs2921077 chr8:8304502 C/T cg21775007 chr8:11205619 TDH 0.4 8.63 0.32 4.81e-17 Mood instability; BRCA cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg23711669 chr6:146136114 FBXO30 0.72 16.49 0.55 3.69e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg25838465 chr1:92012736 NA -0.66 -19.85 -0.62 1.1e-68 Breast cancer; BRCA cis rs1865760 0.865 rs10946800 chr6:25957773 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.38e-21 Height; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs1499972 0.941 rs817508 chr3:117685576 T/C cg07612923 chr3:117604196 NA -0.6 -8.21 -0.31 1.19e-15 Schizophrenia; BRCA cis rs6580649 0.883 rs7967762 chr12:48420214 C/T cg05342945 chr12:48394962 COL2A1 0.44 8.57 0.32 7.75e-17 Lung cancer; BRCA cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg17143192 chr8:8559678 CLDN23 0.55 10.46 0.38 9.4e-24 Obesity-related traits; BRCA trans rs208520 0.560 rs2351880 chr6:66863707 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.85 -0.64 4.92e-74 Exhaled nitric oxide output; BRCA trans rs12517041 1.000 rs7734577 chr5:23290864 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05901451 chr6:126070800 HEY2 0.39 9.59 0.35 1.91e-20 Endometrial cancer; BRCA cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg25174290 chr11:3078921 CARS 0.41 12.06 0.43 2.56e-30 Longevity; BRCA cis rs2506889 0.553 rs7548453 chr1:10589836 A/G cg17425144 chr1:10567563 PEX14 0.55 14.03 0.49 3.39e-39 Breast cancer; BRCA cis rs4566357 0.595 rs10201538 chr2:227914449 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -9.26 -0.34 3.12e-19 Coronary artery disease; BRCA cis rs10752881 0.901 rs10911201 chr1:183001622 G/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.38e-52 Colorectal cancer; BRCA cis rs11785693 0.865 rs7815144 chr8:4970788 G/T cg26367366 chr8:4980734 NA -0.6 -10.77 -0.39 5.53e-25 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg18132916 chr6:79620363 NA -0.45 -10.32 -0.38 3.31e-23 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.13 0.34 8.92e-19 Tonsillectomy; BRCA cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg04756594 chr16:24857601 SLC5A11 -0.46 -9.22 -0.34 4.1e-19 Intelligence (multi-trait analysis); BRCA cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.51 11.22 0.41 8.73e-27 IgG glycosylation; BRCA cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg08477640 chr19:41863820 B9D2 -0.39 -7.97 -0.3 7.17e-15 Migraine;Coronary artery disease; BRCA cis rs61935443 0.832 rs11107768 chr12:95274182 A/T cg21533806 chr12:95267307 NA -0.44 -8.77 -0.33 1.65e-17 Schizophrenia; BRCA cis rs7607369 0.648 rs7559629 chr2:219657013 A/T cg02176678 chr2:219576539 TTLL4 -0.47 -12.25 -0.44 4e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs7824557 0.767 rs11775635 chr8:11164865 G/A cg15556689 chr8:8085844 FLJ10661 0.37 8.72 0.33 2.37e-17 Retinal vascular caliber; BRCA cis rs9287719 0.967 rs6761678 chr2:10746341 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg17971929 chr21:40555470 PSMG1 0.8 19.47 0.61 1.2e-66 Cognitive function; BRCA cis rs61931739 0.517 rs1197562 chr12:34122037 G/A cg06521331 chr12:34319734 NA -0.6 -11.88 -0.43 1.49e-29 Morning vs. evening chronotype; BRCA cis rs4566357 0.615 rs10198406 chr2:227913539 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -8.12 -0.31 2.44e-15 Coronary artery disease; BRCA cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA trans rs75804782 0.515 rs75251934 chr2:239288387 A/C cg01134436 chr17:81009848 B3GNTL1 0.74 7.95 0.3 8.38e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg26384229 chr12:38710491 ALG10B 0.54 13.78 0.48 5.34e-38 Morning vs. evening chronotype; BRCA cis rs1348850 0.914 rs1348849 chr2:178358072 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 10.34 0.38 2.89e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10242455 0.702 rs59240302 chr7:99072991 C/G cg18809830 chr7:99032528 PTCD1 -0.62 -8.83 -0.33 9.64e-18 Blood metabolite levels; BRCA cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg11742103 chr11:62369870 EML3;MTA2 0.54 13.44 0.47 1.96e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9325144 0.647 rs3759139 chr12:39087609 G/A cg26384229 chr12:38710491 ALG10B -0.48 -11.1 -0.4 2.77e-26 Morning vs. evening chronotype; BRCA cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg25173405 chr17:45401733 C17orf57 -0.54 -11.99 -0.43 5.22e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA trans rs60843830 1.000 rs58461606 chr2:267367 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 14.26 0.49 3.04e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs11958404 0.932 rs72816564 chr5:157427484 T/C cg05962755 chr5:157440814 NA 0.58 10.55 0.39 4.36e-24 IgG glycosylation; BRCA cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.03 0.37 4.54e-22 Bladder cancer; BRCA trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21659725 chr3:3221576 CRBN 0.72 22.05 0.66 1.54e-80 Intelligence (multi-trait analysis); BRCA trans rs1941687 0.563 rs2032189 chr18:31332200 T/A cg15819921 chr19:927150 ARID3A -0.43 -8.24 -0.31 9.75e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs897080 0.515 rs1065783 chr2:44660741 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.43 7.97 0.3 7.43e-15 Height; BRCA cis rs6964587 1.000 rs13245393 chr7:91641928 A/G cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.16e-32 Breast cancer; BRCA trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg17830980 chr10:43048298 ZNF37B -0.53 -12.81 -0.45 1.36e-33 Extrinsic epigenetic age acceleration; BRCA cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg12373951 chr3:133503437 NA 0.45 10.74 0.39 7.77e-25 Iron status biomarkers; BRCA cis rs1451375 0.617 rs1376524 chr7:50563582 G/A cg18232548 chr7:50535776 DDC -0.42 -9.09 -0.34 1.19e-18 Malaria; BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.29 -0.47 9.55e-36 Platelet count; BRCA cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg21475434 chr5:93447410 FAM172A 0.66 8.83 0.33 9.99e-18 Diabetic retinopathy; BRCA cis rs10493773 0.609 rs12097932 chr1:86182216 A/G cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.35 -0.47 5.16e-36 Urate levels in overweight individuals; BRCA cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.47 0.5 2.98e-41 Colorectal cancer; BRCA cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg17892150 chr10:133769511 PPP2R2D -0.73 -15.79 -0.53 1.19e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg04455712 chr21:45112962 RRP1B 0.38 9.63 0.36 1.4e-20 Mean corpuscular volume; BRCA cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg19077165 chr18:44547161 KATNAL2 -0.53 -11.42 -0.41 1.23e-27 Personality dimensions; BRCA cis rs67460515 0.892 rs1478566 chr3:161030335 A/T cg03342759 chr3:160939853 NMD3 -0.8 -18.81 -0.6 4.02e-63 Parkinson's disease; BRCA trans rs11098499 0.754 rs4443261 chr4:120249301 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.4 0.38 1.72e-23 Corneal astigmatism; BRCA cis rs7647973 0.593 rs4855885 chr3:49690199 G/A cg03060546 chr3:49711283 APEH 0.56 8.68 0.32 3.36e-17 Menarche (age at onset); BRCA cis rs13046373 0.562 rs12627602 chr21:32022924 G/A cg14062083 chr21:31802829 KRTAP13-4 0.34 9.46 0.35 5.73e-20 HDL cholesterol; BRCA cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg03146154 chr1:46216737 IPP -0.51 -11.33 -0.41 3.08e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs9858542 0.953 rs6446272 chr3:49463287 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.53 -0.35 3.33e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6121246 0.697 rs6088864 chr20:30228157 G/A cg13852791 chr20:30311386 BCL2L1 0.8 14.92 0.51 2.14e-43 Mean corpuscular hemoglobin; BRCA cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg19678392 chr7:94953810 PON1 -0.42 -8.67 -0.32 3.47e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs758324 0.891 rs635164 chr5:131312874 C/T cg06307176 chr5:131281290 NA -0.54 -10.55 -0.39 4.14e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs262150 0.819 rs6956589 chr7:158769301 C/T cg19418458 chr7:158789849 NA -0.43 -9.64 -0.36 1.22e-20 Facial morphology (factor 20); BRCA cis rs73001065 0.591 rs57962361 chr19:19425025 C/T cg03709012 chr19:19516395 GATAD2A 0.88 12.84 0.45 1.03e-33 LDL cholesterol; BRCA cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg24130564 chr14:104152367 KLC1 -0.35 -8.04 -0.3 4.23e-15 Body mass index; BRCA cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg13319975 chr6:146136371 FBXO30 -0.62 -14.34 -0.49 1.2e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs12458462 0.892 rs2242175 chr18:77464406 G/A cg11879182 chr18:77439856 CTDP1 0.64 13.66 0.48 1.85e-37 Monocyte count; BRCA cis rs11997175 0.716 rs7460818 chr8:33816362 A/G ch.8.33884649F chr8:33765107 NA 0.42 10.22 0.37 8.56e-23 Body mass index; BRCA cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg18876405 chr7:65276391 NA -0.5 -11.18 -0.4 1.25e-26 Aortic root size; BRCA cis rs10504073 0.584 rs55908480 chr8:49923431 G/A cg00325661 chr8:49890786 NA 0.51 15.04 0.51 5.21e-44 Blood metabolite ratios; BRCA cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg13628971 chr7:2884303 GNA12 0.38 8.76 0.33 1.73e-17 Height; BRCA cis rs7677751 0.767 rs6831380 chr4:55076345 G/A cg17187183 chr4:55093834 PDGFRA 0.4 8.11 0.31 2.69e-15 Corneal astigmatism; BRCA cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.35 -9.33 -0.35 1.7e-19 Body mass index; BRCA cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg02574844 chr11:5959923 NA -0.4 -8.02 -0.3 5.18e-15 DNA methylation (variation); BRCA cis rs559928 1.000 rs7105178 chr11:64145109 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.57 -8.75 -0.33 1.84e-17 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26314531 chr2:26401878 FAM59B -0.59 -10.14 -0.37 1.68e-22 Gut microbiome composition (summer); BRCA cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.02 15.18 0.51 1.1e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg13944838 chr5:179740914 GFPT2 -0.71 -15.11 -0.51 2.51e-44 Height; BRCA trans rs11098499 0.874 rs6832670 chr4:120118792 A/G cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.8e-24 Corneal astigmatism; BRCA cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 9.9 0.36 1.35e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs2204008 0.526 rs2320448 chr12:38224180 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.74 -0.36 5.26e-21 Bladder cancer; BRCA cis rs490234 0.966 rs542974 chr9:128373218 G/A cg14078157 chr9:128172775 NA 0.33 8.04 0.3 4.28e-15 Mean arterial pressure; BRCA cis rs965469 1.000 rs1040726 chr20:3264267 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.44 -0.38 1.18e-23 IFN-related cytopenia; BRCA cis rs7264396 0.790 rs2207889 chr20:34224898 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.97 0.3 7.5e-15 Total cholesterol levels; BRCA cis rs4728302 0.869 rs6954712 chr7:133618853 G/A cg07491979 chr7:133331646 EXOC4 0.37 7.83 0.3 2.06e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg26116260 chr4:7069785 GRPEL1 -0.91 -19.01 -0.6 3.47e-64 Monocyte percentage of white cells; BRCA cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg27129171 chr3:47204927 SETD2 0.63 13.41 0.47 2.49e-36 Birth weight; BRCA cis rs72627509 0.767 rs6853156 chr4:57774843 C/T cg26694713 chr4:57773883 REST 0.48 9.27 0.34 2.78e-19 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.72 -11.88 -0.43 1.52e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7737355 0.947 rs17167760 chr5:130782699 A/G cg06307176 chr5:131281290 NA -0.55 -10.99 -0.4 7.66e-26 Life satisfaction; BRCA trans rs11976180 1.000 rs7777389 chr7:143744802 T/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.24 -0.31 9.58e-16 Obesity-related traits; BRCA cis rs858239 0.600 rs10256359 chr7:23123877 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.69 0.42 9.57e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg24549020 chr5:56110836 MAP3K1 -0.48 -8.58 -0.32 7.41e-17 Initial pursuit acceleration; BRCA cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg26384229 chr12:38710491 ALG10B 0.7 16.39 0.54 1.2e-50 Bladder cancer; BRCA cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs6142102 0.961 rs6088355 chr20:32545887 A/G cg24642439 chr20:33292090 TP53INP2 0.43 8.03 0.3 4.57e-15 Skin pigmentation; BRCA cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.53 -0.5 1.47e-41 Hemoglobin concentration; BRCA cis rs738322 0.772 rs9619724 chr22:38517880 T/G cg25457927 chr22:38595422 NA -0.29 -10.25 -0.38 6.19e-23 Cutaneous nevi; BRCA cis rs796364 1.000 rs769950 chr2:200730028 A/G cg23649088 chr2:200775458 C2orf69 0.61 9.06 0.34 1.54e-18 Schizophrenia; BRCA cis rs17376456 0.778 rs72786662 chr5:93137630 C/T cg21475434 chr5:93447410 FAM172A 0.7 8.95 0.33 3.8e-18 Diabetic retinopathy; BRCA cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.83 0.3 1.99e-14 Tonsillectomy; BRCA cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg16339924 chr4:17578868 LAP3 0.56 13.82 0.48 3.26e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7617773 0.676 rs13060020 chr3:48372646 C/T cg11946769 chr3:48343235 NME6 0.67 13.41 0.47 2.67e-36 Coronary artery disease; BRCA cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg11266682 chr4:10021025 SLC2A9 0.49 12.86 0.45 8.33e-34 Bone mineral density; BRCA cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg10523679 chr1:76189770 ACADM -0.77 -15.98 -0.53 1.35e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1577917 0.740 rs7771612 chr6:86264374 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 9.0 0.34 2.59e-18 Response to antipsychotic treatment; BRCA cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.3 -0.31 6.38e-16 Bipolar disorder; BRCA cis rs7772486 0.790 rs1133832 chr6:146205604 C/T cg23711669 chr6:146136114 FBXO30 -0.68 -16.34 -0.54 2.12e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs6763687 0.637 rs1875093 chr3:171807714 T/C cg16233210 chr3:171778391 FNDC3B 0.39 9.39 0.35 1e-19 Red cell distribution width; BRCA cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg06784218 chr1:46089804 CCDC17 -0.45 -10.79 -0.39 4.67e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7520050 0.966 rs946529 chr1:46485548 G/T cg24296786 chr1:45957014 TESK2 0.43 9.78 0.36 3.74e-21 Red blood cell count;Reticulocyte count; BRCA cis rs1797081 0.967 rs811912 chr10:16859618 G/C cg23933602 chr10:16859644 RSU1 1.0 32.65 0.79 2.69e-138 Platelet distribution width; BRCA cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg20607287 chr7:12443886 VWDE -0.57 -8.39 -0.31 3.13e-16 Coronary artery disease; BRCA cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg05025164 chr4:1340916 KIAA1530 0.6 12.26 0.44 3.43e-31 Longevity; BRCA cis rs1829883 0.729 rs714385 chr5:98887617 T/C cg08333243 chr5:99726346 NA -0.34 -8.0 -0.3 5.96e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs9287719 0.967 rs1541573 chr2:10773385 T/G cg00105475 chr2:10696890 NA 0.43 9.83 0.36 2.47e-21 Prostate cancer; BRCA cis rs4588572 0.688 rs11743511 chr5:77692819 C/T cg11547950 chr5:77652471 NA -0.43 -8.42 -0.32 2.54e-16 Triglycerides; BRCA cis rs1878931 0.582 rs27238 chr16:3441223 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.51 -8.86 -0.33 8.07e-18 Body mass index (adult); BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg08888203 chr3:10149979 C3orf24 0.56 10.24 0.38 7.16e-23 Alzheimer's disease; BRCA cis rs2637266 1.000 rs7900616 chr10:78367075 C/T cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg02569458 chr12:86230093 RASSF9 0.33 8.14 0.31 2.08e-15 Major depressive disorder; BRCA cis rs11122272 0.735 rs2572249 chr1:231514829 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -12.32 -0.44 1.92e-31 Hemoglobin concentration; BRCA cis rs71636778 0.543 rs17162330 chr1:27236212 A/G cg12203394 chr1:27248618 NUDC 0.6 9.38 0.35 1.14e-19 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs7481584 0.517 rs80872 chr11:3049984 G/T cg08508325 chr11:3079039 CARS 0.28 8.45 0.32 2e-16 Calcium levels; BRCA cis rs7772486 0.743 rs111332144 chr6:146056681 C/T cg23711669 chr6:146136114 FBXO30 -0.62 -13.95 -0.48 8.79e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg10523679 chr1:76189770 ACADM -0.49 -9.52 -0.35 3.5e-20 Daytime sleep phenotypes; BRCA cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2463822 1.000 rs2246920 chr11:62104937 T/G cg06239285 chr11:62104954 ASRGL1 0.67 11.41 0.41 1.38e-27 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg02951883 chr7:2050386 MAD1L1 -0.61 -15.14 -0.51 1.76e-44 Bipolar disorder and schizophrenia; BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg18230493 chr5:56204884 C5orf35 -0.75 -14.62 -0.5 6e-42 Initial pursuit acceleration; BRCA cis rs17401966 1.000 rs12141416 chr1:10327867 A/G cg03954927 chr1:10346856 KIF1B 0.48 15.05 0.51 5.04e-44 Hepatocellular carcinoma; BRCA trans rs8002861 0.967 rs7983109 chr13:44484351 C/A cg17145862 chr1:211918768 LPGAT1 0.69 18.15 0.58 1.04e-59 Leprosy; BRCA cis rs6942756 0.774 rs6946288 chr7:129004277 A/G cg02491457 chr7:128862824 NA -0.57 -11.97 -0.43 6.07e-30 White matter hyperintensity burden; BRCA cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg12310025 chr6:25882481 NA -0.53 -12.02 -0.43 3.91e-30 Intelligence (multi-trait analysis); BRCA cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg25173405 chr17:45401733 C17orf57 -0.52 -10.81 -0.39 3.83e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg23933602 chr10:16859644 RSU1 0.56 9.1 0.34 1.15e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs4919694 0.572 rs12240508 chr10:104939232 G/A cg04362960 chr10:104952993 NT5C2 0.71 12.36 0.44 1.32e-31 Arsenic metabolism; BRCA cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg24060327 chr5:131705240 SLC22A5 -0.47 -9.58 -0.35 2.07e-20 Blood metabolite levels; BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg12016809 chr21:47604291 C21orf56 0.4 8.39 0.32 3.04e-16 Testicular germ cell tumor; BRCA cis rs739401 0.527 rs418832 chr11:3072236 C/T cg05729581 chr11:3078854 CARS -0.35 -8.64 -0.32 4.64e-17 Longevity; BRCA cis rs243505 1.000 rs243515 chr7:148426672 A/C cg09806900 chr7:148480153 CUL1 -0.39 -8.12 -0.31 2.46e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6429082 0.818 rs167092 chr1:235642359 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 14.13 0.49 1.15e-39 Adiposity; BRCA cis rs2204008 0.630 rs12306932 chr12:38242029 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.76 -0.36 4.36e-21 Bladder cancer; BRCA cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.33 0.38 3.03e-23 Calcium levels; BRCA cis rs6120849 0.901 rs6060278 chr20:33753262 T/C cg24642439 chr20:33292090 TP53INP2 0.49 8.93 0.33 4.66e-18 Protein C levels; BRCA cis rs17270561 1.000 rs12211184 chr6:25823774 G/A cg16482183 chr6:26056742 HIST1H1C 0.74 12.96 0.46 2.9e-34 Iron status biomarkers; BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg22920501 chr2:26401640 FAM59B -0.81 -13.19 -0.46 2.66e-35 Gut microbiome composition (summer); BRCA cis rs2243480 1.000 rs58062456 chr7:65394852 G/T cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.54 -0.32 9.57e-17 Extrinsic epigenetic age acceleration; BRCA cis rs8017423 0.647 rs12590712 chr14:90822481 T/C cg04374321 chr14:90722782 PSMC1 -0.49 -11.86 -0.42 1.75e-29 Mortality in heart failure; BRCA cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg03433033 chr1:76189801 ACADM 0.75 16.85 0.55 5.63e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg06108461 chr20:60628389 TAF4 -0.78 -17.09 -0.56 3.18e-54 Body mass index; BRCA cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.55 0.72 2.89e-105 Chronic sinus infection; BRCA cis rs3768617 0.510 rs3768616 chr1:183103551 T/C ch.1.3577855R chr1:183094577 LAMC1 0.62 15.86 0.53 5.42e-48 Fuchs's corneal dystrophy; BRCA cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs701145 0.556 rs355751 chr3:153971602 T/C cg16511985 chr3:153974050 SGEF 0.41 8.96 0.33 3.45e-18 Coronary artery disease; BRCA cis rs11098499 0.866 rs12499602 chr4:120284387 T/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg05234568 chr11:5960015 NA -0.51 -9.93 -0.37 1.04e-21 DNA methylation (variation); BRCA cis rs68170813 0.559 rs7981 chr7:106843133 G/C cg02696742 chr7:106810147 HBP1 -0.52 -8.35 -0.31 4.12e-16 Coronary artery disease; BRCA cis rs4285028 0.699 rs12637968 chr3:121599976 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.73 -13.2 -0.46 2.35e-35 Multiple sclerosis; BRCA cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.17 0.46 3.12e-35 Bipolar disorder; BRCA cis rs6964587 0.934 rs12531561 chr7:91707780 A/G cg17063962 chr7:91808500 NA 0.52 12.35 0.44 1.41e-31 Breast cancer; BRCA cis rs34779708 0.931 rs1926556 chr10:35344907 T/C cg03585969 chr10:35415529 CREM 0.55 11.41 0.41 1.41e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.73e-21 Developmental language disorder (linguistic errors); BRCA cis rs3849570 0.615 rs35779564 chr3:81982771 G/A cg07356753 chr3:81810745 GBE1 -0.34 -7.98 -0.3 6.63e-15 Waist circumference;Body mass index; BRCA cis rs9467773 0.587 rs10946812 chr6:26344975 G/C cg09904177 chr6:26538194 HMGN4 -0.29 -7.86 -0.3 1.63e-14 Intelligence (multi-trait analysis); BRCA cis rs778371 0.915 rs748002 chr2:233757679 G/A cg08000102 chr2:233561755 GIGYF2 -0.75 -16.35 -0.54 1.91e-50 Schizophrenia; BRCA cis rs637571 0.522 rs649000 chr11:65742933 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.47 0.35 5.46e-20 Eosinophil percentage of white cells; BRCA cis rs17095355 1.000 rs55728195 chr10:111715599 G/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.79 -0.36 3.57e-21 Biliary atresia; BRCA cis rs17601876 0.623 rs1062033 chr15:51547938 C/G cg19946085 chr15:51559439 CYP19A1 -0.34 -9.17 -0.34 6.31e-19 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6546550 0.901 rs6546556 chr2:70139001 A/G cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.94e-28 Prevalent atrial fibrillation; BRCA cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg00745463 chr17:30367425 LRRC37B -0.53 -8.85 -0.33 8.4e-18 Hip circumference adjusted for BMI; BRCA cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.06 0.49 2.68e-39 Motion sickness; BRCA cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg08645402 chr16:4508243 NA 0.4 9.25 0.34 3.35e-19 Schizophrenia; BRCA trans rs9858542 0.953 rs9841110 chr3:49492481 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.25 -0.34 3.26e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg00071950 chr4:10020882 SLC2A9 -0.43 -10.08 -0.37 2.75e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.36 0.31 4.06e-16 Rheumatoid arthritis; BRCA cis rs1580019 0.885 rs3801331 chr7:32497039 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.43 -8.93 -0.33 4.34e-18 Cognitive ability; BRCA cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Depression; BRCA cis rs1355223 0.525 rs55796371 chr11:34872769 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs66887589 0.967 rs7678973 chr4:120511817 T/C cg09307838 chr4:120376055 NA -0.44 -9.22 -0.34 4.34e-19 Diastolic blood pressure; BRCA cis rs61931739 0.500 rs11053271 chr12:34545407 C/A cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.08 -0.3 3.26e-15 Total body bone mineral density; BRCA cis rs870825 0.616 rs4263438 chr4:185624238 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7560272 0.502 rs13013228 chr2:73925216 G/A cg20560298 chr2:73613845 ALMS1 0.35 9.13 0.34 8.74e-19 Schizophrenia; BRCA cis rs2688608 0.587 rs2894040 chr10:75478159 A/C cg23231163 chr10:75533350 FUT11 -0.34 -8.83 -0.33 9.85e-18 Inflammatory bowel disease; BRCA cis rs7727544 0.660 rs2631361 chr5:131707380 C/A cg24060327 chr5:131705240 SLC22A5 0.46 9.44 0.35 7.06e-20 Blood metabolite levels; BRCA cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg05025164 chr4:1340916 KIAA1530 -0.62 -12.63 -0.45 8.35e-33 Obesity-related traits; BRCA cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg06046430 chr4:77819534 ANKRD56 0.61 13.63 0.47 2.57e-37 Emphysema distribution in smoking; BRCA cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg24596788 chr1:163392923 NA -0.4 -10.68 -0.39 1.28e-24 Motion sickness; BRCA cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg22974920 chr21:40686053 BRWD1 -0.35 -7.91 -0.3 1.17e-14 Menarche (age at onset); BRCA cis rs2070488 0.965 rs2051215 chr3:38560345 A/G cg24069376 chr3:38537580 EXOG -0.41 -11.76 -0.42 4.65e-29 Electrocardiographic conduction measures; BRCA cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs17095355 1.000 rs12259261 chr10:111725145 A/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.8 -0.36 3.11e-21 Biliary atresia; BRCA cis rs4481887 0.927 rs4381224 chr1:248456826 A/T cg00666640 chr1:248458726 OR2T12 0.35 8.97 0.33 3.21e-18 Common traits (Other); BRCA cis rs7520050 0.931 rs6688365 chr1:46329884 G/C cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.14 0.49 1.06e-39 Colorectal cancer; BRCA cis rs61935443 0.778 rs78522691 chr12:95267340 G/T cg21533806 chr12:95267307 NA 0.45 8.56 0.32 8.66e-17 Schizophrenia; BRCA cis rs17095355 1.000 rs4565840 chr10:111717140 A/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.06 -0.37 3.45e-22 Biliary atresia; BRCA cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg00071950 chr4:10020882 SLC2A9 -0.5 -11.48 -0.41 7.04e-28 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs9329221 0.638 rs12543645 chr8:10246325 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -8.92 -0.33 4.93e-18 Neuroticism; BRCA trans rs61931739 0.635 rs1405024 chr12:33937939 A/T cg26384229 chr12:38710491 ALG10B -0.39 -8.95 -0.33 3.98e-18 Morning vs. evening chronotype; BRCA cis rs3784262 0.669 rs4646594 chr15:58302386 C/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.23 -0.38 7.56e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Depression; BRCA cis rs2985684 0.948 rs4900925 chr14:50012325 A/G cg04989706 chr14:50066350 PPIL5 0.44 8.35 0.31 4.21e-16 Carotid intima media thickness; BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg01262667 chr19:19385393 TM6SF2 0.4 10.33 0.38 3.12e-23 Tonsillectomy; BRCA trans rs11098499 0.754 rs12506487 chr4:120271361 T/G cg25214090 chr10:38739885 LOC399744 0.45 10.66 0.39 1.59e-24 Corneal astigmatism; BRCA cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg18305652 chr10:134549665 INPP5A 0.49 12.03 0.43 3.31e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg26536863 chr7:158807979 LOC154822 -0.36 -8.62 -0.32 5.09e-17 Facial morphology (factor 20); BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg13047869 chr3:10149882 C3orf24 0.57 11.77 0.42 4.49e-29 Alzheimer's disease; BRCA cis rs30380 0.632 rs26489 chr5:96133427 C/T cg16492584 chr5:96139282 ERAP1 -0.46 -11.09 -0.4 2.93e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs3812049 0.667 rs6888037 chr5:127406259 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 11.46 0.41 8.52e-28 Lymphocyte counts;Red cell distribution width; BRCA cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg04450456 chr4:17643702 FAM184B 0.35 9.6 0.36 1.76e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3771570 1.000 rs62193202 chr2:242303717 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg02297831 chr4:17616191 MED28 0.36 7.89 0.3 1.32e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg16339924 chr4:17578868 LAP3 0.56 13.89 0.48 1.62e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7945705 0.791 rs10769958 chr11:8815115 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -10.68 -0.39 1.25e-24 Hemoglobin concentration; BRCA cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg11845111 chr2:191398756 TMEM194B -0.79 -14.81 -0.51 6.99e-43 Diastolic blood pressure; BRCA cis rs8028182 0.636 rs4322627 chr15:75810659 C/T cg20655648 chr15:75932815 IMP3 0.42 8.01 0.3 5.34e-15 Sudden cardiac arrest; BRCA cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg18876405 chr7:65276391 NA -0.5 -11.19 -0.4 1.18e-26 Aortic root size; BRCA cis rs769267 0.965 rs13964 chr19:19468710 C/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.19 -0.43 6.7e-31 Tonsillectomy; BRCA cis rs11083475 0.714 rs7248584 chr19:39258110 C/T cg07905965 chr19:39260460 NA 0.47 11.13 0.4 2.01e-26 Heart rate; BRCA trans rs3733585 0.631 rs3822236 chr4:10119961 T/G cg26043149 chr18:55253948 FECH -0.4 -8.56 -0.32 8.69e-17 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17023223 0.537 rs12064033 chr1:119709558 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs10911232 0.507 rs12037623 chr1:183000148 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs7246657 0.509 rs10426093 chr19:37615629 G/A cg23950597 chr19:37808831 NA -0.64 -9.52 -0.35 3.4e-20 Coronary artery calcification; BRCA cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg04025307 chr7:1156635 C7orf50 0.47 9.11 0.34 1.03e-18 Bronchopulmonary dysplasia; BRCA cis rs7100689 0.646 rs1340384 chr10:82088702 T/A cg00277334 chr10:82204260 NA -0.43 -8.48 -0.32 1.53e-16 Post bronchodilator FEV1; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26314531 chr2:26401878 FAM59B 0.95 16.54 0.55 2.07e-51 Gut microbiome composition (summer); BRCA cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.03 0.4 5.21e-26 Coronary artery disease; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg26608667 chr7:1196370 ZFAND2A 0.43 9.65 0.36 1.13e-20 Longevity;Endometriosis; BRCA cis rs36051895 0.695 rs10120763 chr9:5002911 C/G cg02405213 chr9:5042618 JAK2 -0.47 -8.49 -0.32 1.47e-16 Pediatric autoimmune diseases; BRCA cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.82e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs9467773 1.000 rs6456733 chr6:26566804 C/T cg09904177 chr6:26538194 HMGN4 0.55 17.71 0.57 2.23e-57 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.904 rs2894623 chr2:227766112 T/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.58e-16 Pulmonary function; BRCA cis rs11622475 1.000 rs11625697 chr14:104464800 C/T cg12183467 chr14:104352244 NA -0.49 -10.19 -0.37 1.09e-22 Bipolar disorder; BRCA cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg15556689 chr8:8085844 FLJ10661 0.43 12.23 0.44 4.6e-31 Mood instability; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg04518342 chr5:131593106 PDLIM4 0.37 9.31 0.35 2.02e-19 Breast cancer; BRCA cis rs736408 0.522 rs998909 chr3:52805093 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.58 -0.42 2.69e-28 Bipolar disorder; BRCA cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg08847533 chr14:75593920 NEK9 0.69 15.01 0.51 7.51e-44 Coronary artery disease; BRCA cis rs7824557 0.872 rs2572431 chr8:11105077 C/T cg21775007 chr8:11205619 TDH -0.46 -9.64 -0.36 1.27e-20 Retinal vascular caliber; BRCA cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.66 10.4 0.38 1.6e-23 Schizophrenia; BRCA cis rs7917772 0.636 rs7911747 chr10:104528890 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.56 -0.39 3.96e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg03709012 chr19:19516395 GATAD2A -0.75 -16.72 -0.55 2.46e-52 Tonsillectomy; BRCA cis rs796364 1.000 rs769949 chr2:200729558 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.85 0.45 8.99e-34 Schizophrenia; BRCA cis rs804280 0.525 rs1004712 chr8:11622293 C/T cg12395012 chr8:11607386 GATA4 -0.35 -8.15 -0.31 1.85e-15 Myopia (pathological); BRCA cis rs3820928 0.934 rs1366756 chr2:227772038 G/A cg11843606 chr2:227700838 RHBDD1 -0.37 -8.31 -0.31 5.59e-16 Pulmonary function; BRCA cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg08564027 chr20:61660810 NA 0.85 21.89 0.65 1.06e-79 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.53 -0.32 1.06e-16 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg23708337 chr7:1209742 NA 0.42 8.26 0.31 8.3e-16 Longevity;Endometriosis; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg12016809 chr21:47604291 C21orf56 0.4 8.42 0.32 2.57e-16 Testicular germ cell tumor; BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg05863683 chr7:1912471 MAD1L1 0.4 8.57 0.32 7.59e-17 Bipolar disorder and schizophrenia; BRCA cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg18512352 chr11:47633146 NA 0.32 8.02 0.3 4.99e-15 Subjective well-being; BRCA cis rs7766436 0.561 rs1342206 chr6:22593676 G/A cg13666174 chr6:22585274 NA -0.41 -10.21 -0.37 8.68e-23 Coronary artery disease; BRCA cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg08048268 chr3:133502702 NA -0.32 -8.16 -0.31 1.81e-15 Iron status biomarkers; BRCA cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg00106254 chr7:1943704 MAD1L1 -0.39 -10.05 -0.37 3.81e-22 Bipolar disorder and schizophrenia; BRCA cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg10523679 chr1:76189770 ACADM -0.45 -8.05 -0.3 4.16e-15 Daytime sleep phenotypes; BRCA cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg07828340 chr4:882639 GAK 0.86 10.53 0.38 4.92e-24 Parkinson's disease; BRCA cis rs6499255 0.951 rs16959025 chr16:69695589 G/T cg15192750 chr16:69999425 NA -0.58 -8.94 -0.33 4.03e-18 IgE levels; BRCA cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg20891283 chr12:69753455 YEATS4 0.73 21.66 0.65 1.94e-78 Blood protein levels; BRCA cis rs6866344 0.570 rs1132336 chr5:178140090 C/T cg03877680 chr5:178157825 ZNF354A 0.82 16.29 0.54 3.56e-50 Neutrophil percentage of white cells; BRCA cis rs7267979 0.744 rs6050463 chr20:25208990 G/A cg08601574 chr20:25228251 PYGB 0.35 8.22 0.31 1.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg19077165 chr18:44547161 KATNAL2 0.39 8.47 0.32 1.67e-16 Personality dimensions; BRCA cis rs742320 0.756 rs3765263 chr16:840378 A/G cg03433313 chr16:819064 MIR662 -0.51 -10.48 -0.38 8.24e-24 Mean corpuscular volume; BRCA trans rs7824557 0.701 rs2060465 chr8:11162609 T/C cg08975724 chr8:8085496 FLJ10661 0.43 8.03 0.3 4.59e-15 Retinal vascular caliber; BRCA cis rs1997103 0.863 rs2140916 chr7:55403154 A/C cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs16854884 0.657 rs13086088 chr3:143723942 G/A cg06585982 chr3:143692056 C3orf58 0.43 9.04 0.34 1.92e-18 Economic and political preferences (feminism/equality); BRCA cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg09537434 chr19:41945824 ATP5SL -0.63 -13.12 -0.46 5.22e-35 Migraine;Coronary artery disease; BRCA cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -10.2 -0.37 9.69e-23 Autism spectrum disorder or schizophrenia; BRCA cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg24130564 chr14:104152367 KLC1 0.36 8.21 0.31 1.25e-15 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg25517755 chr10:38738941 LOC399744 -0.4 -8.03 -0.3 4.59e-15 Corneal astigmatism; BRCA cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg07606381 chr6:8435919 SLC35B3 0.64 13.85 0.48 2.4e-38 Motion sickness; BRCA cis rs9814567 1.000 rs13096604 chr3:134250099 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg06212747 chr3:49208901 KLHDC8B 0.45 9.36 0.35 1.36e-19 Parkinson's disease; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg21782813 chr7:2030301 MAD1L1 -0.4 -11.8 -0.42 3.23e-29 Bipolar disorder and schizophrenia; BRCA cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg26597838 chr10:835615 NA 0.73 10.7 0.39 1.11e-24 Eosinophil percentage of granulocytes; BRCA cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.58 0.32 7.41e-17 Diabetic retinopathy; BRCA cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg23711669 chr6:146136114 FBXO30 -0.8 -19.32 -0.61 8.01e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg08470875 chr2:26401718 FAM59B -0.51 -8.22 -0.31 1.14e-15 Gut microbiome composition (summer); BRCA cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11890956 chr21:40555474 PSMG1 1.07 31.04 0.78 1.05e-129 Cognitive function; BRCA cis rs10752881 0.935 rs10911197 chr1:182995399 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Colorectal cancer; BRCA cis rs1153858 0.945 rs16943246 chr15:45720597 G/A cg21132104 chr15:45694354 SPATA5L1 0.67 14.03 0.49 3.66e-39 Homoarginine levels; BRCA cis rs2115630 1.000 rs6496452 chr15:85372645 A/T cg11189052 chr15:85197271 WDR73 -0.36 -8.71 -0.33 2.66e-17 P wave terminal force; BRCA cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg21918786 chr6:109611834 NA -0.45 -12.1 -0.43 1.74e-30 Reticulocyte fraction of red cells; BRCA cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg08564027 chr20:61660810 NA 0.85 23.04 0.67 5.44e-86 Prostate cancer (SNP x SNP interaction); BRCA cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg01874867 chr7:94954059 PON1 -0.39 -8.02 -0.3 4.93e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg04518342 chr5:131593106 PDLIM4 0.36 9.03 0.34 1.99e-18 Breast cancer; BRCA cis rs6545883 0.894 rs778148 chr2:61606866 G/A cg15711740 chr2:61764176 XPO1 0.49 12.13 0.43 1.33e-30 Tuberculosis; BRCA cis rs4975616 0.773 rs10078017 chr5:1314009 C/T cg07493874 chr5:1342172 CLPTM1L 0.44 12.0 0.43 4.74e-30 Lung cancer; BRCA cis rs4363385 0.667 rs399550 chr1:153049917 T/C cg24667326 chr1:152973720 SPRR3 -0.3 -7.92 -0.3 1.07e-14 Inflammatory skin disease; BRCA cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg17330251 chr7:94953956 PON1 -0.43 -9.06 -0.34 1.51e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs644148 0.803 rs2686771 chr19:44999494 T/C cg15540054 chr19:45004280 ZNF180 -0.57 -12.28 -0.44 2.9e-31 Personality dimensions; BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg00814883 chr7:100076585 TSC22D4 -0.47 -10.53 -0.38 5.1900000000000004e-24 Platelet count; BRCA trans rs9944715 0.954 rs12457740 chr18:43741742 G/A cg01718231 chr17:29326311 RNF135 0.44 8.95 0.33 3.74e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs7903847 0.620 rs17112676 chr10:99122288 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.19 -0.31 1.46e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs7267979 0.933 rs6138571 chr20:25435388 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.38 -8.31 -0.31 5.7e-16 Educational attainment; BRCA cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.22 -0.31 1.16e-15 Axial length; BRCA trans rs6951245 1.000 rs80094748 chr7:1103958 G/A cg13565492 chr6:43139072 SRF -0.78 -10.67 -0.39 1.44e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg14196790 chr5:131705035 SLC22A5 0.33 8.66 0.32 3.85e-17 Breast cancer; BRCA cis rs11997175 0.583 rs17780571 chr8:33817821 G/C ch.8.33884649F chr8:33765107 NA 0.37 8.52 0.32 1.14e-16 Body mass index; BRCA cis rs7927771 0.507 rs7111606 chr11:47787538 G/A cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs2463822 0.858 rs2463836 chr11:62126494 A/G cg06239285 chr11:62104954 ASRGL1 0.69 11.52 0.41 4.72e-28 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 14.5 0.5 2.09e-41 Alzheimer's disease; BRCA cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.44 9.31 0.35 2.04e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs6121246 0.512 rs45443696 chr20:30311396 A/C cg21427119 chr20:30132790 HM13 -0.36 -8.09 -0.3 3.1e-15 Mean corpuscular hemoglobin; BRCA cis rs13064411 0.696 rs1486894 chr3:113211513 G/A cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs12541635 0.639 rs10095827 chr8:106984403 A/G cg10147462 chr8:107024639 NA 0.4 10.77 0.39 5.51e-25 Age of smoking initiation; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.68 -13.77 -0.48 5.85e-38 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6120849 0.851 rs13040631 chr20:33747714 T/C cg24642439 chr20:33292090 TP53INP2 0.48 8.61 0.32 5.91e-17 Protein C levels; BRCA cis rs3087591 1.000 rs2525578 chr17:29711411 A/G cg24425628 chr17:29625626 OMG;NF1 -0.45 -9.44 -0.35 6.74e-20 Hip circumference; BRCA cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg08859206 chr1:53392774 SCP2 0.49 10.84 0.39 2.91e-25 Monocyte count; BRCA cis rs796364 0.951 rs281776 chr2:200834282 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.81 13.47 0.47 1.45e-36 Schizophrenia; BRCA cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg24829409 chr8:58192753 C8orf71 -0.57 -12.24 -0.44 4.41e-31 Developmental language disorder (linguistic errors); BRCA cis rs701145 0.585 rs242577 chr3:153941208 G/A cg17054900 chr3:154042577 DHX36 0.58 9.74 0.36 5.2e-21 Coronary artery disease; BRCA cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg03452623 chr4:187889614 NA -0.35 -11.44 -0.41 1.08e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs1200821 0.529 rs2475206 chr10:37802532 A/G cg25427524 chr10:38739819 LOC399744 0.46 9.8 0.36 3.22e-21 Hemostatic factors and hematological phenotypes; BRCA cis rs870825 0.616 rs6834156 chr4:185639903 G/C cg04058563 chr4:185651563 MLF1IP 0.77 17.21 0.56 7.75e-55 Blood protein levels; BRCA cis rs4423214 0.592 rs11233933 chr11:71210070 C/T cg05163923 chr11:71159392 DHCR7 -0.48 -8.43 -0.32 2.34e-16 Vitamin D levels; BRCA cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg04455712 chr21:45112962 RRP1B 0.38 9.71 0.36 7.17e-21 Mean corpuscular volume; BRCA cis rs7301826 0.610 rs7961690 chr12:131296880 G/T cg11011512 chr12:131303247 STX2 -0.45 -11.17 -0.4 1.44e-26 Plasma plasminogen activator levels; BRCA cis rs9296092 0.560 rs9469502 chr6:33526648 G/A cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs17641971 0.645 rs341806 chr8:50034028 A/C cg00325661 chr8:49890786 NA 0.35 9.51 0.35 3.71e-20 Blood metabolite levels; BRCA cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs561341 1.000 rs498391 chr17:30328704 G/A cg23018236 chr17:30244563 NA -0.63 -10.28 -0.38 4.91e-23 Hip circumference adjusted for BMI; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.31 -0.44 2.07e-31 Lymphocyte counts; BRCA cis rs365132 0.875 rs353476 chr5:176424035 A/G cg16309518 chr5:176445507 NA -0.4 -9.72 -0.36 6.41e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.95e-38 Mean platelet volume; BRCA cis rs2806561 0.606 rs218341 chr1:23294153 G/C cg12483005 chr1:23474871 LUZP1 0.42 9.17 0.34 6.34e-19 Height; BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg23583168 chr7:148888333 NA -0.85 -19.73 -0.62 4.99e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9674544 0.757 rs4410130 chr17:47122942 C/T cg11673840 chr17:47092156 IGF2BP1 0.32 7.94 0.3 9.19e-15 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13217239 0.646 rs12527111 chr6:27006475 C/T cg12292205 chr6:26970375 C6orf41 0.57 12.64 0.45 7.47e-33 Schizophrenia; BRCA cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg06028605 chr16:24865363 SLC5A11 0.45 9.93 0.37 1.05e-21 Intelligence (multi-trait analysis); BRCA cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg02951883 chr7:2050386 MAD1L1 -0.48 -10.58 -0.39 3.35e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg21747090 chr2:27597821 SNX17 -0.43 -9.27 -0.34 2.87e-19 Total body bone mineral density; BRCA trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg20587970 chr11:113659929 NA -1.23 -22.07 -0.66 1.11e-80 Hip circumference adjusted for BMI; BRCA cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.07 0.37 3.19e-22 Bipolar disorder; BRCA cis rs9814567 0.964 rs3856729 chr3:134200925 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.28 -0.61 1.29e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg01448562 chr3:133502909 NA 0.39 8.96 0.33 3.5e-18 Alcohol consumption (transferrin glycosylation); BRCA cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg08213375 chr14:104286397 PPP1R13B 0.64 18.47 0.59 2.2e-61 Schizophrenia; BRCA cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg09877947 chr5:131593287 PDLIM4 0.37 7.93 0.3 1.01e-14 Breast cancer; BRCA cis rs6890695 1 rs6890695 chr5:130888424 C/G cg06307176 chr5:131281290 NA 0.53 10.64 0.39 1.96e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg18876405 chr7:65276391 NA 0.55 13.29 0.47 9.4e-36 Aortic root size; BRCA cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA trans rs7980799 0.649 rs2389218 chr12:33680929 C/A cg26384229 chr12:38710491 ALG10B 0.52 10.95 0.4 1.09e-25 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg04025307 chr7:1156635 C7orf50 0.58 9.0 0.34 2.5e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.95 -0.37 8.79e-22 Alzheimer's disease (late onset); BRCA trans rs877282 0.945 rs35342920 chr10:790484 T/C cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg26384229 chr12:38710491 ALG10B 0.74 17.77 0.58 1.03e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs561341 1.000 rs550923 chr17:30327013 G/C cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.63e-17 Hip circumference adjusted for BMI; BRCA cis rs738321 0.757 rs4821748 chr22:38541936 G/A cg25457927 chr22:38595422 NA -0.36 -12.61 -0.45 1.02e-32 Breast cancer; BRCA cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg25173405 chr17:45401733 C17orf57 0.52 11.16 0.4 1.46e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.09 -0.34 1.19e-18 Menopause (age at onset); BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg04166393 chr7:2884313 GNA12 0.48 9.16 0.34 7e-19 Height; BRCA cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg08975724 chr8:8085496 FLJ10661 0.52 11.13 0.4 1.95e-26 Mood instability; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg04013093 chr6:42928303 GNMT -0.27 -8.51 -0.32 1.23e-16 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg11742103 chr11:62369870 EML3;MTA2 0.54 11.41 0.41 1.44e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg06064525 chr11:970664 AP2A2 -0.3 -8.7 -0.33 2.87e-17 Alzheimer's disease (late onset); BRCA cis rs8014204 0.762 rs10148293 chr14:75296831 C/T cg06637938 chr14:75390232 RPS6KL1 -0.42 -8.76 -0.33 1.81e-17 Caffeine consumption; BRCA cis rs72781680 0.756 rs2712059 chr2:24020539 T/C cg08917208 chr2:24149416 ATAD2B 0.57 9.43 0.35 7.39e-20 Lymphocyte counts; BRCA trans rs11098499 0.863 rs1480936 chr4:120462861 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.2 0.43 6.68e-31 Corneal astigmatism; BRCA cis rs1020064 0.636 rs2679883 chr2:105949668 C/T cg02079111 chr2:105885981 TGFBRAP1 0.42 7.95 0.3 8.73e-15 AIDS; BRCA cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -15.66 -0.53 5.1e-47 Extrinsic epigenetic age acceleration; BRCA cis rs853679 0.546 rs493161 chr6:27850714 A/T cg26587870 chr6:27730563 NA -0.53 -7.88 -0.3 1.42e-14 Depression; BRCA cis rs631288 0.557 rs4534444 chr1:146679283 T/C cg25205988 chr1:146714368 CHD1L 0.81 7.86 0.3 1.6e-14 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg06115741 chr20:33292138 TP53INP2 0.39 8.58 0.32 7.19e-17 Glomerular filtration rate (creatinine); BRCA cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.56 9.0 0.34 2.59e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs11971779 0.752 rs4732371 chr7:139077317 T/A cg07862535 chr7:139043722 LUC7L2 0.41 11.02 0.4 5.68e-26 Diisocyanate-induced asthma; BRCA cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg11764359 chr7:65958608 NA -0.65 -14.23 -0.49 4.19e-40 Aortic root size; BRCA cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg14844989 chr11:31128820 NA 0.45 10.02 0.37 4.89e-22 Red blood cell count; BRCA cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg13319975 chr6:146136371 FBXO30 0.35 8.07 0.3 3.42e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg24549020 chr5:56110836 MAP3K1 -0.39 -8.35 -0.31 4.14e-16 Coronary artery disease; BRCA trans rs2018683 0.707 rs1021690 chr7:28974488 A/G cg19402173 chr7:128379420 CALU -0.42 -9.92 -0.37 1.1e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.09 0.43 1.94e-30 Attention deficit hyperactivity disorder; BRCA cis rs4588572 0.643 rs6453391 chr5:77755035 T/C cg11547950 chr5:77652471 NA -0.47 -8.4 -0.32 2.81e-16 Triglycerides; BRCA cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14829155 chr15:31115871 NA -0.41 -9.68 -0.36 8.8e-21 Huntington's disease progression; BRCA cis rs6545883 0.524 rs778159 chr2:61556744 T/C cg15711740 chr2:61764176 XPO1 0.32 7.86 0.3 1.62e-14 Tuberculosis; BRCA cis rs12541635 0.967 rs11997513 chr8:107093325 C/T cg10147462 chr8:107024639 NA -0.29 -7.84 -0.3 1.84e-14 Age of smoking initiation; BRCA cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg08807101 chr21:30365312 RNF160 0.75 19.73 0.62 5.14e-68 Dental caries; BRCA cis rs11809207 0.523 rs2783706 chr1:26504697 A/G cg23602478 chr1:26503979 CNKSR1 0.23 7.95 0.3 8.44e-15 Height; BRCA cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg10523679 chr1:76189770 ACADM -0.59 -11.06 -0.4 4.06e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs35146811 0.731 rs2257213 chr7:99810113 T/C cg22906224 chr7:99728672 NA -0.43 -8.09 -0.3 2.95e-15 Coronary artery disease; BRCA cis rs13272623 0.502 rs268594 chr8:71513130 C/T cg23757474 chr8:71581111 LACTB2;XKR9 0.43 8.91 0.33 5.17e-18 IgG glycosylation; BRCA cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 8.02 0.3 4.98e-15 Mean platelet volume; BRCA cis rs6142102 0.625 rs4012234 chr20:32553047 T/G cg24642439 chr20:33292090 TP53INP2 0.39 7.82 0.3 2.17e-14 Skin pigmentation; BRCA cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11890956 chr21:40555474 PSMG1 1.04 29.33 0.76 1.92e-120 Cognitive function; BRCA cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.69 0.45 4.39e-33 Mean platelet volume; BRCA cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg24060327 chr5:131705240 SLC22A5 -0.49 -10.22 -0.37 8.39e-23 Blood metabolite levels; BRCA cis rs3796619 1.000 rs1466215 chr4:1072220 C/T cg27284194 chr4:1044797 NA 0.44 9.42 0.35 7.8500000000000006e-20 Recombination rate (males); BRCA cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.3 0.49 1.92e-40 Motion sickness; BRCA cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs4302748 0.862 rs79729347 chr7:36184584 G/A cg24442661 chr7:36192818 EEPD1 0.49 8.87 0.33 7.24e-18 Platelet count; BRCA cis rs4481887 0.927 rs4244181 chr1:248471118 A/G cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.9e-18 Common traits (Other); BRCA cis rs4363385 0.747 rs4845508 chr1:152968421 G/C cg21543102 chr1:152974771 SPRR3 -0.3 -8.3 -0.31 6.13e-16 Inflammatory skin disease; BRCA trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg06636001 chr8:8085503 FLJ10661 -0.53 -11.18 -0.4 1.22e-26 Neuroticism; BRCA cis rs10876993 0.928 rs1628552 chr12:58082142 C/T cg18357645 chr12:58087776 OS9 0.48 13.61 0.47 3.19e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs7809950 0.731 rs2712196 chr7:107128797 G/T cg23024343 chr7:107201750 COG5 -0.49 -10.34 -0.38 2.95e-23 Coronary artery disease; BRCA cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg06808227 chr14:105710500 BRF1 -0.79 -16.08 -0.54 4.3e-49 Mean platelet volume;Platelet distribution width; BRCA trans rs2204008 0.744 rs8186814 chr12:38335169 C/T cg06521331 chr12:34319734 NA -0.48 -8.79 -0.33 1.39e-17 Bladder cancer; BRCA cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg06640241 chr16:89574553 SPG7 -0.55 -12.33 -0.44 1.72e-31 Multiple myeloma (IgH translocation); BRCA trans rs17685 0.753 rs12531559 chr7:75631697 C/T cg19862616 chr7:65841803 NCRNA00174 -0.8 -25.29 -0.71 2.52e-98 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg22029157 chr1:209979665 IRF6 0.53 12.09 0.43 1.83e-30 Cleft lip with or without cleft palate; BRCA cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg03060546 chr3:49711283 APEH 0.6 9.83 0.36 2.5e-21 Menarche (age at onset); BRCA cis rs6964587 0.967 rs4729015 chr7:91561592 T/G cg17063962 chr7:91808500 NA -0.51 -11.89 -0.43 1.32e-29 Breast cancer; BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -15.12 -0.51 2.36e-44 Bipolar disorder and schizophrenia; BRCA cis rs6952809 0.532 rs10272548 chr7:2439467 G/A cg23289794 chr7:2394357 EIF3B -0.64 -11.97 -0.43 6.36e-30 Multiple sclerosis; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg00106254 chr7:1943704 MAD1L1 -0.39 -9.6 -0.36 1.72e-20 Bipolar disorder and schizophrenia; BRCA cis rs9646954 0.542 rs11674830 chr2:101024735 A/G cg08017756 chr2:100939284 LONRF2 -0.3 -7.89 -0.3 1.27e-14 Intelligence (multi-trait analysis); BRCA cis rs2806561 0.765 rs4333826 chr1:23517514 C/T cg12483005 chr1:23474871 LUZP1 0.44 9.81 0.36 2.88e-21 Height; BRCA cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg15485101 chr11:133734466 NA 0.4 10.08 0.37 2.78e-22 Childhood ear infection; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg05793240 chr7:2802953 GNA12 -0.31 -7.81 -0.3 2.37e-14 Height; BRCA cis rs7524258 0.868 rs2412153 chr1:7272412 C/T cg07173049 chr1:7289937 CAMTA1 0.48 11.71 0.42 8.08e-29 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg18850127 chr7:39170497 POU6F2 0.49 10.42 0.38 1.36e-23 IgG glycosylation; BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg03354898 chr7:1950403 MAD1L1 -0.44 -8.87 -0.33 7.37e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs7647973 0.667 rs6446286 chr3:49681704 A/G cg03060546 chr3:49711283 APEH 0.6 10.31 0.38 3.56e-23 Menarche (age at onset); BRCA cis rs911119 0.954 rs35966482 chr20:23620716 G/T cg16589663 chr20:23618590 CST3 0.46 8.73 0.33 2.21e-17 Chronic kidney disease; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9318086 0.663 rs2312295 chr13:24457744 A/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.3 8.4 0.32 2.79e-16 Myopia (pathological); BRCA cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.59e-19 Motion sickness; BRCA cis rs1499972 0.887 rs1499970 chr3:117692767 G/A cg07612923 chr3:117604196 NA -0.6 -8.14 -0.31 2.14e-15 Schizophrenia; BRCA cis rs3125734 0.633 rs6479791 chr10:63980341 T/C cg19640130 chr10:64028056 RTKN2 -0.31 -9.07 -0.34 1.4e-18 Rheumatoid arthritis; BRCA cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg20476274 chr7:133979776 SLC35B4 0.59 16.4 0.54 9.86e-51 Mean platelet volume; BRCA cis rs6028335 0.674 rs57993460 chr20:37662068 C/A cg16355469 chr20:37678765 NA 0.48 8.67 0.32 3.57e-17 Alcohol and nicotine co-dependence; BRCA cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg22676075 chr6:135203613 NA 0.44 8.56 0.32 8.6e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg17971929 chr21:40555470 PSMG1 -0.47 -10.42 -0.38 1.38e-23 Menarche (age at onset); BRCA trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.04 -0.34 1.8e-18 Resting heart rate; BRCA cis rs4919087 0.892 rs10882880 chr10:99008068 G/A cg25902810 chr10:99078978 FRAT1 0.43 9.15 0.34 7.7e-19 Monocyte count; BRCA cis rs7246657 0.943 rs13345116 chr19:37847098 A/T cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.67 11.34 0.41 2.78e-27 Lung function (FEV1/FVC); BRCA cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg12591125 chr7:1885375 MAD1L1 0.51 8.93 0.33 4.6e-18 Bipolar disorder; BRCA cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -13.16 -0.46 3.62e-35 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11644478 chr21:40555479 PSMG1 -0.55 -11.79 -0.42 3.59e-29 Menarche (age at onset); BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.71 -0.42 7.78e-29 Gut microbiome composition (summer); BRCA cis rs7267979 1.000 rs6050573 chr20:25366065 C/G cg08601574 chr20:25228251 PYGB 0.33 7.91 0.3 1.14e-14 Liver enzyme levels (alkaline phosphatase); BRCA trans rs11165623 0.543 rs6656866 chr1:97002238 T/C cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.18e-30 Hip circumference;Waist circumference; BRCA trans rs7824557 0.778 rs6601572 chr8:11093337 C/G cg15556689 chr8:8085844 FLJ10661 -0.34 -8.45 -0.32 1.95e-16 Retinal vascular caliber; BRCA cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg03146154 chr1:46216737 IPP -0.44 -9.78 -0.36 3.68e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg08213375 chr14:104286397 PPP1R13B 0.63 18.0 0.58 6.9e-59 Schizophrenia; BRCA cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg02175503 chr12:58329896 NA 0.43 8.48 0.32 1.58e-16 Intelligence (multi-trait analysis); BRCA cis rs9473147 0.543 rs13211285 chr6:47479618 C/T cg12968598 chr6:47444699 CD2AP 0.43 9.51 0.35 3.85e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg25251562 chr2:3704773 ALLC -0.42 -7.98 -0.3 6.88e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs7572733 0.534 rs1607375 chr2:198800387 C/T cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.53e-21 Dermatomyositis; BRCA cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg08601574 chr20:25228251 PYGB 0.35 8.23 0.31 1.02e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs16866061 1.000 rs10933068 chr2:225418360 G/A cg12698349 chr2:225449008 CUL3 0.78 21.58 0.65 5.64e-78 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2859741 0.967 rs494157 chr1:37512995 C/T cg09363841 chr1:37513479 NA 0.68 17.65 0.57 4.49e-57 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs4845875 0.600 rs6696752 chr1:11835935 T/C cg24844545 chr1:11908347 NPPA 0.38 8.75 0.33 1.82e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg15395560 chr15:45543142 SLC28A2 -0.29 -7.83 -0.3 2.02e-14 Uric acid levels; BRCA cis rs6430585 0.528 rs56064699 chr2:136595706 G/A cg07169764 chr2:136633963 MCM6 1.31 26.09 0.72 9.68e-103 Corneal structure; BRCA trans rs4596713 0.538 rs7048094 chr9:71745660 G/C cg16512924 chr15:28394682 HERC2 0.4 9.45 0.35 6.24e-20 Headache; BRCA cis rs911119 1.000 rs5030707 chr20:23618656 C/G cg16589663 chr20:23618590 CST3 0.47 8.84 0.33 9.27e-18 Chronic kidney disease; BRCA trans rs2204008 0.837 rs11181857 chr12:38413255 C/G cg06521331 chr12:34319734 NA -0.46 -8.73 -0.33 2.23e-17 Bladder cancer; BRCA cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg00071950 chr4:10020882 SLC2A9 0.54 13.35 0.47 4.83e-36 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.48 0.35 4.92e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg08564027 chr20:61660810 NA 0.84 22.69 0.67 4.62e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10819733 chr22:24237672 NA -0.3 -8.44 -0.32 2.08e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg23711669 chr6:146136114 FBXO30 0.74 17.02 0.56 7.93e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467711 0.651 rs35402046 chr6:26099472 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.6 9.63 0.36 1.39e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs490234 0.812 rs4329365 chr9:128445758 A/C cg14078157 chr9:128172775 NA -0.45 -10.03 -0.37 4.39e-22 Mean arterial pressure; BRCA cis rs6430585 0.583 rs58116536 chr2:136585323 C/T cg07169764 chr2:136633963 MCM6 1.32 32.94 0.79 7.3e-140 Corneal structure; BRCA cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 14.75 0.5 1.35e-42 Colorectal cancer; BRCA cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg06453172 chr10:134556979 INPP5A -0.58 -12.15 -0.43 1.04e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6582630 0.512 rs11182667 chr12:38588392 C/A cg26384229 chr12:38710491 ALG10B -0.46 -10.53 -0.38 5.05e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.52 9.12 0.34 9.47e-19 Schizophrenia; BRCA cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg17366294 chr4:99064904 C4orf37 0.41 9.7 0.36 7.41e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs13102973 0.965 rs11099306 chr4:135895674 A/G cg14419869 chr4:135874104 NA 0.52 10.97 0.4 9.3e-26 Subjective well-being; BRCA cis rs4713118 0.911 rs9461406 chr6:27719764 C/T cg20933634 chr6:27740509 NA -0.41 -7.85 -0.3 1.76e-14 Parkinson's disease; BRCA cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg10932868 chr11:921992 NA 0.38 9.03 0.34 1.93e-18 Alzheimer's disease (late onset); BRCA cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.05 0.3 3.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs765787 0.530 rs2899379 chr15:45534799 C/T cg24006582 chr15:45444508 DUOX1 0.54 10.55 0.39 4.14e-24 Uric acid levels; BRCA cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg17366294 chr4:99064904 C4orf37 0.52 11.54 0.42 4.23e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg04267008 chr7:1944627 MAD1L1 -0.6 -13.52 -0.47 8.46e-37 Bipolar disorder and schizophrenia; BRCA cis rs270601 0.633 rs733300 chr5:131572243 A/G cg11843238 chr5:131593191 PDLIM4 0.38 9.34 0.35 1.56e-19 Acylcarnitine levels; BRCA cis rs10089 1.000 rs11957052 chr5:127524055 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.55 12.62 0.45 9.24e-33 Ileal carcinoids; BRCA cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg18964960 chr10:1102726 WDR37 -0.58 -7.87 -0.3 1.5e-14 Eosinophil percentage of granulocytes; BRCA cis rs250677 0.522 rs11954893 chr5:148392362 A/G cg18129178 chr5:148520854 ABLIM3 -0.54 -10.53 -0.38 5.23e-24 Breast cancer; BRCA cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg13334819 chr7:99746414 C7orf59 0.45 10.49 0.38 7.52e-24 Coronary artery disease; BRCA cis rs877282 0.945 rs35342920 chr10:790484 T/C cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA trans rs6479891 1.000 rs7899715 chr10:65078455 T/C cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.62e-16 Arthritis (juvenile idiopathic); BRCA cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.4 0.5 6.27e-41 Motion sickness; BRCA cis rs10751667 0.560 rs10902267 chr11:1007831 T/C cg06064525 chr11:970664 AP2A2 -0.28 -8.22 -0.31 1.12e-15 Alzheimer's disease (late onset); BRCA cis rs7772486 0.743 rs9376955 chr6:145949404 T/A cg23711669 chr6:146136114 FBXO30 0.71 17.15 0.56 1.55e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg09658497 chr7:2847517 GNA12 -0.4 -8.57 -0.32 8e-17 Height; BRCA cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg08917208 chr2:24149416 ATAD2B 0.57 9.07 0.34 1.43e-18 Lymphocyte counts; BRCA cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11644478 chr21:40555479 PSMG1 -0.66 -14.23 -0.49 3.94e-40 Cognitive function; BRCA cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg06552810 chr11:31128660 NA -0.38 -8.41 -0.32 2.64e-16 Red blood cell count; BRCA cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.2 0.31 1.29e-15 Cognitive ability; BRCA cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs939658 0.935 rs2204069 chr15:79449335 A/G cg17916960 chr15:79447300 NA 0.43 10.72 0.39 9.4e-25 Refractive error; BRCA trans rs9291683 0.588 rs35866697 chr4:10018604 C/A cg26043149 chr18:55253948 FECH 0.39 8.44 0.32 2.2e-16 Bone mineral density; BRCA cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.51e-36 High light scatter reticulocyte count; BRCA cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg07395648 chr5:131743802 NA -0.38 -8.27 -0.31 7.67e-16 Breast cancer; BRCA cis rs12541635 1.000 rs2881037 chr8:107090901 C/T cg10147462 chr8:107024639 NA -0.3 -8.24 -0.31 9.5e-16 Age of smoking initiation; BRCA cis rs921968 0.643 rs523396 chr2:219338789 T/G cg02176678 chr2:219576539 TTLL4 0.39 10.4 0.38 1.64e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg27446573 chr6:127587934 RNF146 0.89 20.41 0.63 1.09e-71 Breast cancer; BRCA trans rs57046232 0.552 rs6054166 chr20:6348251 A/C cg21095983 chr6:86352623 SYNCRIP 0.38 7.98 0.3 6.64e-15 Colorectal cancer; BRCA cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg24069376 chr3:38537580 EXOG 0.32 8.83 0.33 1e-17 Electrocardiographic conduction measures; BRCA cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg11663144 chr21:46675770 NA -0.61 -14.16 -0.49 8.39e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs6782228 0.651 rs9289332 chr3:128387884 C/G cg16766828 chr3:128327626 NA -0.43 -9.49 -0.35 4.68e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs9858542 0.953 rs9827021 chr3:49514764 C/A cg03060546 chr3:49711283 APEH -0.54 -10.99 -0.4 7.38e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg14789911 chr21:47582049 C21orf56 -0.36 -7.84 -0.3 1.83e-14 Testicular germ cell tumor; BRCA cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg16109817 chr1:16162209 FLJ37453 0.3 8.31 0.31 5.64e-16 Systolic blood pressure; BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24549020 chr5:56110836 MAP3K1 0.66 13.4 0.47 3.01e-36 Initial pursuit acceleration; BRCA cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg06618935 chr21:46677482 NA -0.38 -8.56 -0.32 8.68e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg06618935 chr21:46677482 NA 0.36 7.91 0.3 1.1e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10037055 1.000 rs6886255 chr5:176718361 A/G cg06733329 chr5:176740039 MXD3 -0.41 -9.75 -0.36 4.78e-21 Migraine without aura; BRCA cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg09184832 chr6:79620586 NA -0.53 -11.52 -0.41 4.77e-28 Intelligence (multi-trait analysis); BRCA cis rs4908768 0.539 rs11121205 chr1:8658085 G/A cg20416874 chr1:8611966 RERE -0.28 -7.86 -0.3 1.64e-14 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1003719 0.743 rs2835615 chr21:38497303 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.25 -0.49 3.38e-40 Eye color traits; BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg26608667 chr7:1196370 ZFAND2A 0.38 9.18 0.34 5.92e-19 Longevity;Endometriosis; BRCA cis rs7264396 0.790 rs2425096 chr20:34308588 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.74 -15.96 -0.53 1.63e-48 Total cholesterol levels; BRCA cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg26384229 chr12:38710491 ALG10B -0.55 -13.14 -0.46 4.58e-35 Morning vs. evening chronotype; BRCA trans rs7939886 0.764 rs11227350 chr11:55912289 T/C cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.84 -0.33 9.14e-18 Reticulocyte count; BRCA cis rs7833986 0.501 rs2953909 chr8:56968200 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.38 0.47 3.61e-36 Height; BRCA cis rs6430585 0.583 rs4594504 chr2:136625113 A/C cg07169764 chr2:136633963 MCM6 1.28 28.6 0.75 1.86e-116 Corneal structure; BRCA cis rs2732480 0.538 rs2468943 chr12:48747249 G/T cg04545296 chr12:48745243 ZNF641 -0.25 -8.4 -0.32 2.9e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs514406 0.679 rs960570 chr1:53237763 A/G cg24675658 chr1:53192096 ZYG11B 0.83 18.75 0.6 7.51e-63 Monocyte count; BRCA cis rs7254827 0.868 rs3745349 chr19:17212992 C/T cg19418318 chr19:17219073 MYO9B -0.51 -10.34 -0.38 2.79e-23 Mean platelet volume; BRCA cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg11168104 chr5:1857477 NA -0.33 -8.88 -0.33 6.46e-18 Cardiovascular disease risk factors; BRCA cis rs9473147 0.516 rs9463342 chr6:47585106 A/T cg12968598 chr6:47444699 CD2AP 0.44 9.58 0.35 2.15e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg25173405 chr17:45401733 C17orf57 0.48 9.81 0.36 2.87e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs61931739 0.929 rs1490110 chr12:34091605 A/G cg26384229 chr12:38710491 ALG10B -0.45 -10.73 -0.39 8.24e-25 Morning vs. evening chronotype; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg21226059 chr5:178986404 RUFY1 -0.53 -15.07 -0.51 3.79e-44 Lung cancer; BRCA trans rs877282 0.945 rs877280 chr10:771599 C/T cg22713356 chr15:30763199 NA 1.35 27.49 0.74 2.15e-110 Uric acid levels; BRCA cis rs72928364 1.000 rs41273553 chr3:100617532 T/C cg10123952 chr3:100791384 NA 0.54 7.95 0.3 8.19e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.46 0.38 9.2e-24 IgG glycosylation; BRCA cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg08885076 chr2:99613938 TSGA10 0.53 11.78 0.42 3.88e-29 Chronic sinus infection; BRCA cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg22117172 chr7:91764530 CYP51A1 -0.23 -7.87 -0.3 1.47e-14 Breast cancer; BRCA cis rs17095355 1.000 rs17126890 chr10:111699169 T/C cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.32 -0.38 3.24e-23 Biliary atresia; BRCA cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg18230493 chr5:56204884 C5orf35 -0.72 -14.03 -0.49 3.47e-39 Initial pursuit acceleration; BRCA cis rs9837602 0.688 rs793488 chr3:99495567 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -10.79 -0.39 4.67e-25 Breast cancer; BRCA cis rs6582630 0.599 rs1851114 chr12:38424671 C/T cg26384229 chr12:38710491 ALG10B -0.43 -10.06 -0.37 3.32e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg05535760 chr7:792225 HEATR2 0.71 13.04 0.46 1.21e-34 Cerebrospinal P-tau181p levels; BRCA cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg19784903 chr17:45786737 TBKBP1 -0.34 -8.02 -0.3 4.92e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4319547 0.661 rs10773172 chr12:122939655 G/A cg23029597 chr12:123009494 RSRC2 -0.48 -9.56 -0.35 2.57e-20 Body mass index; BRCA cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg24562669 chr7:97807699 LMTK2 0.45 11.96 0.43 6.76e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs11809207 0.568 rs1892494 chr1:26497626 C/G cg23602478 chr1:26503979 CNKSR1 0.23 8.03 0.3 4.83e-15 Height; BRCA cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg09467607 chr2:36825704 FEZ2 -0.55 -13.86 -0.48 2.09e-38 Height; BRCA cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg06784218 chr1:46089804 CCDC17 -0.53 -12.92 -0.45 4.51e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs208515 0.525 rs10755508 chr6:66675790 T/C cg07460842 chr6:66804631 NA 0.77 14.02 0.48 4.08e-39 Exhaled nitric oxide levels; BRCA trans rs11722228 0.549 rs3796818 chr4:10097976 C/T cg26043149 chr18:55253948 FECH 1.09 23.48 0.68 2.32e-88 Gout;Urate levels;Serum uric acid levels; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00149659 chr3:10157352 C3orf10 0.77 13.14 0.46 4.31e-35 Alzheimer's disease; BRCA cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg15605315 chr1:45957053 TESK2 0.49 10.21 0.37 8.77e-23 High light scatter reticulocyte count; BRCA cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg21856205 chr7:94953877 PON1 -0.37 -7.89 -0.3 1.31e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg08000102 chr2:233561755 GIGYF2 -0.47 -10.43 -0.38 1.26e-23 Coronary artery disease; BRCA cis rs7647973 0.626 rs4855849 chr3:49653378 A/G cg03060546 chr3:49711283 APEH 0.6 10.21 0.37 8.9e-23 Menarche (age at onset); BRCA trans rs3733585 0.699 rs10001964 chr4:9959275 C/T cg26043149 chr18:55253948 FECH -0.37 -8.21 -0.31 1.2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg18132916 chr6:79620363 NA -0.45 -9.96 -0.37 8.37e-22 Intelligence (multi-trait analysis); BRCA cis rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05901451 chr6:126070800 HEY2 0.41 10.01 0.37 5.02e-22 Endometrial cancer; BRCA cis rs3820928 0.839 rs13404750 chr2:227876129 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.79 -0.33 1.33e-17 Pulmonary function; BRCA cis rs270601 0.683 rs81598 chr5:131587960 C/G cg07262247 chr5:131593730 PDLIM4 0.34 7.87 0.3 1.51e-14 Acylcarnitine levels; BRCA trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg19077165 chr18:44547161 KATNAL2 -0.58 -12.73 -0.45 2.98e-33 Personality dimensions; BRCA cis rs344364 0.511 rs911391 chr16:1947016 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.49e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg02353165 chr6:42928485 GNMT 0.78 18.84 0.6 2.77e-63 Plasma homocysteine levels (post-methionine load test); BRCA trans rs7746199 0.736 rs67652222 chr6:27586220 C/T cg06606381 chr12:133084897 FBRSL1 -0.86 -8.5 -0.32 1.33e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg08999081 chr20:33150536 PIGU 0.5 14.01 0.48 4.45e-39 Coronary artery disease; BRCA cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg06636001 chr8:8085503 FLJ10661 -0.45 -9.46 -0.35 5.67e-20 Joint mobility (Beighton score); BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg08885076 chr2:99613938 TSGA10 -0.57 -12.88 -0.45 6.45e-34 Chronic sinus infection; BRCA cis rs7572733 0.515 rs700675 chr2:198700216 G/A cg00792783 chr2:198669748 PLCL1 0.47 10.17 0.37 1.28e-22 Dermatomyositis; BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg04944784 chr2:26401820 FAM59B -0.85 -13.27 -0.46 1.19e-35 Gut microbiome composition (summer); BRCA cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg18132916 chr6:79620363 NA -0.45 -10.16 -0.37 1.44e-22 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.593 rs9295678 chr6:25937033 G/A cg12310025 chr6:25882481 NA -0.38 -8.79 -0.33 1.32e-17 Height; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg22903471 chr2:27725779 GCKR -0.35 -8.51 -0.32 1.24e-16 Total body bone mineral density; BRCA cis rs10463316 0.832 rs246486 chr5:150727880 C/T cg03212797 chr5:150827313 SLC36A1 0.48 9.41 0.35 8.64e-20 Metabolite levels (Pyroglutamine); BRCA cis rs478304 0.934 rs603645 chr11:65533000 A/C cg08755490 chr11:65554678 OVOL1 0.53 10.97 0.4 8.98e-26 Acne (severe); BRCA cis rs34293785 1.000 rs34293785 chr1:66137192 T/C cg04111102 chr1:66153794 NA 0.36 8.71 0.33 2.67e-17 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Sum basophil neutrophil counts;Neutrophil count;White blood cell count; BRCA cis rs7091068 0.616 rs4322326 chr10:95483382 A/T cg20715218 chr10:95462985 C10orf4 0.46 8.57 0.32 7.96e-17 Urinary tract infection frequency; BRCA cis rs6032067 0.673 rs13042474 chr20:43893068 G/T cg20256260 chr20:43936981 MATN4;RBPJL 0.34 8.19 0.31 1.47e-15 Blood protein levels; BRCA cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg20219911 chr3:52813652 ITIH1 0.29 7.83 0.3 1.97e-14 Electroencephalogram traits; BRCA cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg06115741 chr20:33292138 TP53INP2 0.38 8.46 0.32 1.86e-16 Glomerular filtration rate (creatinine); BRCA trans rs61931739 0.927 rs12315970 chr12:34038535 A/G cg26384229 chr12:38710491 ALG10B -0.41 -9.33 -0.35 1.76e-19 Morning vs. evening chronotype; BRCA cis rs9986765 1.000 rs73452570 chr7:142817482 T/A cg22531018 chr7:142981779 TMEM139 0.58 9.61 0.36 1.58e-20 Cancer;Dermatomyositis; BRCA cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.06e-21 Developmental language disorder (linguistic errors); BRCA cis rs1348850 0.914 rs6710575 chr2:178377311 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 9.69 0.36 8.32e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs3771570 0.901 rs4075818 chr2:242432142 T/C cg21155796 chr2:242212141 HDLBP 0.63 9.7 0.36 7.62e-21 Prostate cancer; BRCA cis rs752010 0.714 rs7515948 chr1:42079046 T/G cg06885757 chr1:42089581 HIVEP3 0.28 10.24 0.38 6.6e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs30380 0.632 rs27434 chr5:96129512 A/G cg16492584 chr5:96139282 ERAP1 -0.46 -10.95 -0.4 1.04e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs72772090 0.522 rs76961889 chr5:95987932 G/T cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -8.15 -0.31 1.91e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs919433 0.783 rs787979 chr2:198242868 A/T cg00792783 chr2:198669748 PLCL1 0.35 7.92 0.3 1.09e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg17063962 chr7:91808500 NA 0.54 12.91 0.45 4.89e-34 Breast cancer; BRCA cis rs2479724 0.818 rs9357369 chr6:41818202 A/C cg17623882 chr6:41773611 USP49 -0.38 -10.33 -0.38 2.97e-23 Menarche (age at onset); BRCA cis rs9640161 0.742 rs2159236 chr7:150017214 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.55 -13.35 -0.47 4.84e-36 Blood protein levels;Circulating chemerin levels; BRCA cis rs6840360 0.550 rs7675818 chr4:152690777 C/G cg22705602 chr4:152727874 NA -0.38 -10.5 -0.38 6.91e-24 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg21475434 chr5:93447410 FAM172A -0.71 -8.9 -0.33 5.79e-18 Diabetic retinopathy; BRCA cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg02951883 chr7:2050386 MAD1L1 -0.35 -8.04 -0.3 4.43e-15 Bipolar disorder and schizophrenia; BRCA cis rs600806 0.745 rs4246517 chr1:110007636 G/C cg20591472 chr1:110008990 SYPL2 0.33 8.38 0.31 3.29e-16 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg13010199 chr12:38710504 ALG10B 0.5 10.4 0.38 1.68e-23 Bladder cancer; BRCA trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg23505145 chr19:12996616 KLF1 0.53 11.99 0.43 5.27e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg13047869 chr3:10149882 C3orf24 0.6 12.76 0.45 2.33e-33 Alzheimer's disease; BRCA cis rs9290065 0.519 rs1530636 chr3:160697442 A/G cg03342759 chr3:160939853 NMD3 0.47 9.49 0.35 4.38e-20 Kawasaki disease; BRCA cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg26597838 chr10:835615 NA -1.0 -17.46 -0.57 3.92e-56 Eosinophil percentage of granulocytes; BRCA cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -9.84 -0.36 2.22e-21 Schizophrenia; BRCA cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg00677455 chr12:58241039 CTDSP2 0.63 15.54 0.52 1.94e-46 Multiple sclerosis; BRCA cis rs798554 0.704 rs798512 chr7:2782592 C/G cg13628971 chr7:2884303 GNA12 0.39 8.47 0.32 1.72e-16 Height; BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.01 0.43 4.17e-30 Tonsillectomy; BRCA cis rs35661897 0.920 rs4490174 chr2:227325171 G/A cg03426602 chr2:227312417 NA -0.5 -8.09 -0.3 3.11e-15 Urinary tract infection frequency; BRCA cis rs2294693 0.891 rs9369256 chr6:40998344 G/C cg14418226 chr6:40996092 UNC5CL 0.47 8.57 0.32 7.82e-17 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs6834538 0.597 rs9991830 chr4:113485372 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.41 9.77 0.36 4.3e-21 Free thyroxine concentration; BRCA cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg06636001 chr8:8085503 FLJ10661 -0.47 -10.44 -0.38 1.16e-23 Mood instability; BRCA cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 0.32 8.02 0.3 5.22e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg20701182 chr2:24300061 SF3B14 0.63 8.97 0.33 3.36e-18 Lymphocyte counts; BRCA cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg25174290 chr11:3078921 CARS -0.43 -12.78 -0.45 1.76e-33 Longevity; BRCA cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.15 0.37 1.55e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs1997103 1.000 rs12532070 chr7:55407698 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg26384229 chr12:38710491 ALG10B -0.53 -12.76 -0.45 2.2e-33 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs35110281 0.517 rs11089020 chr21:44939991 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.83 0.33 1.02e-17 Mean corpuscular volume; BRCA cis rs10046574 0.831 rs77693675 chr7:135142402 T/C cg27474649 chr7:135195673 CNOT4 0.61 8.71 0.33 2.65e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs796364 0.951 rs281769 chr2:200809709 T/C cg23649088 chr2:200775458 C2orf69 0.59 8.66 0.32 3.85e-17 Schizophrenia; BRCA cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg03477792 chr4:77819574 ANKRD56 0.64 15.42 0.52 7.8e-46 Emphysema distribution in smoking; BRCA cis rs7131987 0.683 rs7954278 chr12:29459290 G/A cg09582351 chr12:29534625 ERGIC2 -0.44 -10.36 -0.38 2.36e-23 QT interval; BRCA cis rs34779708 0.966 rs10827492 chr10:35429825 A/G cg03585969 chr10:35415529 CREM -0.49 -10.26 -0.38 5.62e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.7 10.61 0.39 2.47e-24 Lung function (FEV1/FVC); BRCA cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg18876405 chr7:65276391 NA 0.5 11.1 0.4 2.63e-26 Aortic root size; BRCA cis rs7395581 0.918 rs3847502 chr11:47333685 C/A cg25783544 chr11:47291846 MADD 0.42 9.52 0.35 3.6e-20 HDL cholesterol; BRCA cis rs13082711 0.554 rs35840701 chr3:27334231 A/C cg02860705 chr3:27208620 NA 0.75 13.91 0.48 1.24e-38 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg09658497 chr7:2847517 GNA12 -0.48 -10.62 -0.39 2.21e-24 Plateletcrit; BRCA cis rs11690935 0.851 rs7573003 chr2:172741415 T/A cg13550731 chr2:172543902 DYNC1I2 -0.81 -23.79 -0.69 4.31e-90 Schizophrenia; BRCA cis rs870825 0.929 rs55746424 chr4:185589603 C/T cg20176042 chr4:185552304 CASP3 -0.6 -8.12 -0.31 2.37e-15 Blood protein levels; BRCA cis rs9649465 1.000 rs2896334 chr7:123367705 A/C cg04330084 chr7:123175371 IQUB -0.31 -8.54 -0.32 9.74e-17 Migraine; BRCA trans rs3960554 0.808 rs11983987 chr7:75657850 A/G cg19862616 chr7:65841803 NCRNA00174 0.58 12.21 0.43 5.66e-31 Eotaxin levels; BRCA trans rs61931739 1.000 rs11052989 chr12:34057614 G/A cg26384229 chr12:38710491 ALG10B -0.41 -9.17 -0.34 6.25e-19 Morning vs. evening chronotype; BRCA cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.23e-15 Aortic root size; BRCA cis rs10870270 1.000 rs6560695 chr10:133774986 C/A cg08754478 chr10:133766260 PPP2R2D -0.68 -14.17 -0.49 7.88e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.71 10.88 0.4 2.03e-25 Lung function (FEV1/FVC); BRCA trans rs877282 1.000 rs12219807 chr10:772870 A/C cg22713356 chr15:30763199 NA 1.2 24.44 0.7 1.23e-93 Uric acid levels; BRCA cis rs2645694 0.651 rs2703128 chr4:77819187 C/G cg10057126 chr4:77819792 ANKRD56 0.65 15.17 0.51 1.24e-44 Emphysema distribution in smoking; BRCA cis rs3820928 0.874 rs4234066 chr2:227882180 G/A cg11843606 chr2:227700838 RHBDD1 -0.36 -7.95 -0.3 8.19e-15 Pulmonary function; BRCA cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.56 11.9 0.43 1.23e-29 Age-related macular degeneration (geographic atrophy); BRCA cis rs11785693 0.862 rs6995565 chr8:4990461 C/T cg26367366 chr8:4980734 NA -0.57 -9.83 -0.36 2.56e-21 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg12573674 chr2:1569213 NA -0.56 -12.3 -0.44 2.4e-31 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg23791538 chr6:167370224 RNASET2 -0.44 -11.01 -0.4 6.36e-26 Crohn's disease; BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg21782813 chr7:2030301 MAD1L1 0.34 9.09 0.34 1.23e-18 Bipolar disorder and schizophrenia; BRCA cis rs7927771 1.000 rs11039255 chr11:47495746 G/T cg18512352 chr11:47633146 NA -0.36 -8.99 -0.34 2.74e-18 Subjective well-being; BRCA cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.46 10.19 0.37 1.08e-22 Cognitive ability; BRCA cis rs9329289 0.888 rs11251273 chr10:2540300 G/C cg15501526 chr10:2543763 NA 0.56 13.79 0.48 4.55e-38 Age-related hearing impairment; BRCA cis rs7584330 0.518 rs78856668 chr2:238438055 A/C cg08992911 chr2:238395768 MLPH 0.53 8.31 0.31 5.62e-16 Prostate cancer; BRCA cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg26031613 chr14:104095156 KLC1 0.44 8.73 0.33 2.14e-17 Schizophrenia; BRCA trans rs11098499 0.754 rs11098502 chr4:120252063 T/A cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg08213375 chr14:104286397 PPP1R13B 0.63 18.06 0.58 3.25e-59 Schizophrenia; BRCA cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg06636001 chr8:8085503 FLJ10661 0.47 10.27 0.38 5.37e-23 Joint mobility (Beighton score); BRCA cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs427394 1.000 rs427394 chr5:6745875 A/G cg10857441 chr5:6722123 POLS -0.31 -10.29 -0.38 4.26e-23 Menopause (age at onset); BRCA cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.66 -0.32 3.85e-17 Developmental language disorder (linguistic errors); BRCA cis rs9814567 0.806 rs4955534 chr3:134319723 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.55 -10.0 -0.37 5.66e-22 Renal function-related traits (BUN); BRCA cis rs7191700 0.511 rs8043625 chr16:11361895 C/G cg00044050 chr16:11439710 C16orf75 -0.42 -9.72 -0.36 6.13e-21 Multiple sclerosis; BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg03709012 chr19:19516395 GATAD2A -0.8 -18.43 -0.59 3.95e-61 Tonsillectomy; BRCA cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg18446336 chr7:2847575 GNA12 -0.35 -8.31 -0.31 5.85e-16 Height; BRCA cis rs7914558 1.000 rs7094843 chr10:104806654 A/C cg04362960 chr10:104952993 NT5C2 0.43 10.32 0.38 3.32e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs897080 0.515 rs1067319 chr2:44633458 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.41 0.35 8.74e-20 Height; BRCA cis rs8180040 0.764 rs11716539 chr3:47186503 G/T cg16586182 chr3:47516702 SCAP -0.56 -12.96 -0.46 2.81e-34 Colorectal cancer; BRCA cis rs2108225 0.900 rs2051956 chr7:107441358 G/C cg18560240 chr7:107437656 SLC26A3 -0.56 -11.72 -0.42 7.12e-29 Ulcerative colitis; BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg27170947 chr2:26402098 FAM59B -0.7 -11.81 -0.42 3.07e-29 Gut microbiome composition (summer); BRCA trans rs12517041 1.000 rs2081950 chr5:23287505 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs10992471 0.528 rs7860786 chr9:95245473 C/T cg14631576 chr9:95140430 CENPP -0.33 -8.41 -0.32 2.68e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg19196401 chr6:110721138 DDO -0.41 -10.23 -0.38 7.51e-23 Platelet distribution width; BRCA cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg08219700 chr8:58056026 NA 0.54 8.9 0.33 5.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs9986765 0.867 rs1994498 chr7:142816448 C/T cg15652212 chr7:142981776 TMEM139 0.57 9.4 0.35 9.23e-20 Cancer;Dermatomyositis; BRCA cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg20503657 chr10:835505 NA 0.9 16.21 0.54 9.56e-50 Eosinophil percentage of granulocytes; BRCA cis rs4466137 0.903 rs3734092 chr5:83016743 C/T cg15083037 chr5:83017644 HAPLN1 -0.54 -10.92 -0.4 1.49e-25 Prostate cancer; BRCA cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg21535247 chr6:8435926 SLC35B3 0.39 8.85 0.33 8.55e-18 Motion sickness; BRCA cis rs10911232 0.524 rs4487994 chr1:182982173 T/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.71 0.55 2.93e-52 Hypertriglyceridemia; BRCA cis rs34779708 0.702 rs7087150 chr10:35542138 A/T cg03585969 chr10:35415529 CREM 0.45 9.23 0.34 3.93e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs514406 0.547 rs377808 chr1:53190359 T/G cg24675658 chr1:53192096 ZYG11B -0.69 -14.79 -0.5 9.16e-43 Monocyte count; BRCA cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.32 -0.44 1.93e-31 Bipolar disorder; BRCA cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg24549020 chr5:56110836 MAP3K1 0.67 13.55 0.47 6.1e-37 Initial pursuit acceleration; BRCA cis rs10782582 0.609 rs5745543 chr1:76365111 A/T cg03433033 chr1:76189801 ACADM -0.38 -7.97 -0.3 7.45e-15 Daytime sleep phenotypes; BRCA cis rs11098499 0.955 rs1551 chr4:120158500 T/G cg09307838 chr4:120376055 NA 0.61 12.31 0.44 2.23e-31 Corneal astigmatism; BRCA cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg10057126 chr4:77819792 ANKRD56 0.65 14.76 0.5 1.2e-42 Emphysema distribution in smoking; BRCA cis rs3892630 0.757 rs8109823 chr19:33183316 A/G cg22980127 chr19:33182716 NUDT19 0.9 18.16 0.58 9.86e-60 Red blood cell traits; BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26314531 chr2:26401878 FAM59B 0.95 16.58 0.55 1.33e-51 Gut microbiome composition (summer); BRCA cis rs7246657 0.653 rs10401525 chr19:37658979 C/G cg18154014 chr19:37997991 ZNF793 0.54 8.99 0.34 2.81e-18 Coronary artery calcification; BRCA cis rs3892630 0.878 rs114224536 chr19:33211232 A/G cg22980127 chr19:33182716 NUDT19 0.9 17.54 0.57 1.69e-56 Red blood cell traits; BRCA cis rs1008375 0.931 rs10939733 chr4:17570658 T/C cg15017067 chr4:17643749 FAM184B 0.33 10.12 0.37 1.91e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg03517284 chr6:25882590 NA -0.46 -9.64 -0.36 1.27e-20 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg11764359 chr7:65958608 NA 0.64 10.96 0.4 9.82e-26 Aortic root size; BRCA trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg11707556 chr5:10655725 ANKRD33B 0.4 8.55 0.32 9.24e-17 Coronary artery disease; BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg18402987 chr7:1209562 NA 0.67 11.68 0.42 1.07e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7267979 1.000 rs6107045 chr20:25441936 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.5 0.32 1.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg08085267 chr17:45401833 C17orf57 -0.64 -13.91 -0.48 1.36e-38 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.75e-15 Developmental language disorder (linguistic errors); BRCA cis rs11229555 0.645 rs12272911 chr11:58183839 G/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6782228 0.585 rs2811492 chr3:128356279 A/G cg16766828 chr3:128327626 NA -0.43 -9.68 -0.36 9.36e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg26119090 chr2:26468346 HADHA;HADHB 0.99 21.22 0.64 4.87e-76 Gut microbiome composition (summer); BRCA cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 18.33 0.59 1.3e-60 Hip circumference adjusted for BMI; BRCA cis rs7553864 0.614 rs10493796 chr1:87614175 A/G cg17420885 chr1:87600446 LOC339524 0.4 7.96 0.3 7.78e-15 Smoking behavior; BRCA cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg10295955 chr4:187884368 NA -0.9 -26.24 -0.72 1.48e-103 Lobe attachment (rater-scored or self-reported); BRCA cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs72781680 0.716 rs2712065 chr2:23973603 C/T cg08917208 chr2:24149416 ATAD2B -0.54 -9.18 -0.34 5.91e-19 Lymphocyte counts; BRCA cis rs10911232 0.507 rs4652765 chr1:182994147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs1568889 1.000 rs78140392 chr11:28203231 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 13.3 0.47 8.19e-36 Bipolar disorder; BRCA cis rs1577917 0.958 rs12192033 chr6:86472559 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.7 -0.45 4.2e-33 Response to antipsychotic treatment; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.02 -0.4 5.67e-26 Lymphocyte counts; BRCA cis rs477692 0.549 rs7098548 chr10:131455028 A/G cg05714579 chr10:131428358 MGMT -0.45 -9.84 -0.36 2.27e-21 Response to temozolomide; BRCA cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.96 -0.33 3.63e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.66 0.71 2.38e-100 Chronic sinus infection; BRCA cis rs11098499 0.863 rs6534139 chr4:120449456 A/G cg09307838 chr4:120376055 NA -0.68 -13.55 -0.47 6.02e-37 Corneal astigmatism; BRCA cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg18876405 chr7:65276391 NA 0.58 14.5 0.5 2.06e-41 Aortic root size; BRCA cis rs11190604 1.000 rs2495759 chr10:102320363 C/T cg07080220 chr10:102295463 HIF1AN 0.65 12.92 0.46 4.1e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs965469 0.779 rs6051683 chr20:3237822 G/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.73 -0.33 2.27e-17 IFN-related cytopenia; BRCA cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg26384229 chr12:38710491 ALG10B -0.58 -13.54 -0.47 6.62e-37 Bladder cancer; BRCA cis rs6087771 0.926 rs6058431 chr20:30297133 C/T cg13852791 chr20:30311386 BCL2L1 0.86 18.56 0.59 7.93e-62 Subcortical brain region volumes;Putamen volume; BRCA cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg21770322 chr7:97807741 LMTK2 0.42 11.1 0.4 2.55e-26 Prostate cancer (SNP x SNP interaction); BRCA trans rs1493916 1.000 rs4393645 chr18:31394407 C/T cg15819921 chr19:927150 ARID3A -0.48 -9.17 -0.34 6.5e-19 Life satisfaction; BRCA cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg09065629 chr16:1709722 CRAMP1L 0.36 8.37 0.31 3.59e-16 Coronary artery disease; BRCA cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg24060327 chr5:131705240 SLC22A5 -0.63 -12.27 -0.44 3.2e-31 Breast cancer; BRCA cis rs2274273 1.000 rs6573006 chr14:55610432 T/C cg04306507 chr14:55594613 LGALS3 0.32 9.0 0.34 2.57e-18 Protein biomarker; BRCA cis rs965469 1.000 rs2281497 chr20:3258874 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -10.56 -0.39 3.93e-24 IFN-related cytopenia; BRCA cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg15698299 chr3:52233019 ALAS1 -0.4 -9.61 -0.36 1.58e-20 Electroencephalogram traits; BRCA cis rs4478858 0.735 rs7556340 chr1:31788453 A/T cg00250761 chr1:31883323 NA -0.3 -7.93 -0.3 9.88e-15 Alcohol dependence; BRCA cis rs870825 1.000 rs9995633 chr4:185584441 C/T cg04058563 chr4:185651563 MLF1IP 0.69 12.56 0.45 1.65e-32 Blood protein levels; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2742234 0.955 rs2435385 chr10:43665750 A/G cg02780029 chr10:43622663 RET -0.39 -9.55 -0.35 2.82e-20 Hirschsprung disease; BRCA cis rs11785693 0.862 rs17435605 chr8:4987302 A/G cg26367366 chr8:4980734 NA 0.63 11.37 0.41 2.14e-27 Neuroticism (multi-trait analysis);Neuroticism; BRCA trans rs6600671 0.899 rs11249432 chr1:121283476 T/A cg00646200 chr1:148855367 NA 0.32 8.13 0.31 2.2e-15 Hip geometry; BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg00166722 chr3:10149974 C3orf24 0.67 13.3 0.47 8.21e-36 Alzheimer's disease; BRCA cis rs6120849 0.754 rs3746436 chr20:33586193 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.35 0.38 2.61e-23 Protein C levels; BRCA cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg21518248 chr2:162101506 NA -0.47 -10.13 -0.37 1.78e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs4891159 0.790 rs35516239 chr18:74129942 C/T cg24786174 chr18:74118243 ZNF516 -0.76 -18.61 -0.59 4.07e-62 Longevity; BRCA cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.07 -0.4 3.59e-26 IgG glycosylation; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg27170947 chr2:26402098 FAM59B 0.93 16.66 0.55 4.84e-52 Gut microbiome composition (summer); BRCA cis rs9560113 1.000 rs9555810 chr13:112181437 C/G cg10483660 chr13:112241077 NA 0.32 8.02 0.3 5.06e-15 Menarche (age at onset); BRCA cis rs68170813 0.523 rs79619227 chr7:107025335 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.6 -0.32 6.19e-17 Coronary artery disease; BRCA cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg09469691 chr10:81107165 PPIF 0.5 10.5 0.38 6.62e-24 Height; BRCA cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs739401 0.611 rs402276 chr11:3051404 C/G cg25174290 chr11:3078921 CARS 0.44 13.35 0.47 5.15e-36 Longevity; BRCA cis rs4561483 0.801 rs33637 chr16:11989875 A/T cg08843971 chr16:11963173 GSPT1 -0.52 -11.97 -0.43 6.16e-30 Testicular germ cell tumor; BRCA trans rs35110281 0.666 rs2236665 chr21:45108987 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.29 0.31 6.69e-16 Mean corpuscular volume; BRCA cis rs9549260 0.753 rs9532563 chr13:41160270 T/C cg21288729 chr13:41239152 FOXO1 0.55 9.18 0.34 5.85e-19 Red blood cell count; BRCA cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.06 0.34 1.6e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs514406 0.679 rs499239 chr1:53310594 A/G cg08859206 chr1:53392774 SCP2 -0.59 -12.81 -0.45 1.39e-33 Monocyte count; BRCA cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg01181863 chr3:195395398 SDHAP2 -0.46 -8.05 -0.3 4.19e-15 Pancreatic cancer; BRCA cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg16586182 chr3:47516702 SCAP 0.51 11.42 0.41 1.27e-27 Colorectal cancer; BRCA cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg08885076 chr2:99613938 TSGA10 0.46 10.73 0.39 8.53e-25 Chronic sinus infection; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg22337977 chr21:31811175 KRTAP15-1 0.36 8.67 0.32 3.6e-17 HDL cholesterol; BRCA cis rs870825 0.616 rs10428373 chr4:185639002 A/T cg04058563 chr4:185651563 MLF1IP 0.77 17.27 0.56 4.14e-55 Blood protein levels; BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg25036284 chr2:26402008 FAM59B -0.66 -11.21 -0.41 9.28e-27 Gut microbiome composition (summer); BRCA cis rs425277 1.000 rs809912 chr1:2078385 C/T cg00981070 chr1:2046702 PRKCZ 0.31 8.25 0.31 9.06e-16 Height; BRCA trans rs911555 0.755 rs17841064 chr14:103900609 A/G cg17675199 chr6:35436792 RPL10A 0.3 8.12 0.31 2.32e-15 Intelligence (multi-trait analysis); BRCA cis rs8062405 1.000 rs62036657 chr16:28844365 G/A cg09754948 chr16:28834200 ATXN2L 0.46 9.13 0.34 9.04e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11890956 chr21:40555474 PSMG1 -0.82 -19.54 -0.61 5.3800000000000003e-67 Cognitive function; BRCA cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs34779708 0.733 rs3936503 chr10:35549257 A/G cg03585969 chr10:35415529 CREM -0.42 -8.73 -0.33 2.27e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs524281 0.861 rs918299 chr11:65927607 C/T cg16950941 chr11:66035639 RAB1B -0.37 -8.02 -0.3 4.9e-15 Electroencephalogram traits; BRCA cis rs11098499 0.754 rs17595608 chr4:120250506 C/T cg09307838 chr4:120376055 NA 0.64 13.8 0.48 4.15e-38 Corneal astigmatism; BRCA cis rs829883 0.616 rs249832 chr12:98832387 C/T cg25150519 chr12:98850993 NA 0.66 16.05 0.54 5.72e-49 Colorectal adenoma (advanced); BRCA cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.51 -0.32 1.21e-16 Colorectal cancer; BRCA cis rs11190604 0.767 rs77769532 chr10:102193646 T/C cg07080220 chr10:102295463 HIF1AN 0.44 9.8 0.36 3.19e-21 Palmitoleic acid (16:1n-7) levels; BRCA trans rs208520 0.779 rs208446 chr6:66903515 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -15.98 -0.53 1.37e-48 Exhaled nitric oxide output; BRCA cis rs10492096 0.947 rs10849482 chr12:6635274 G/A cg13857086 chr12:6580257 VAMP1 0.43 8.26 0.31 8.61e-16 Hip geometry; BRCA cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.67 0.36 9.85e-21 Parkinson's disease; BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg12000995 chr2:27665139 KRTCAP3 -0.35 -9.0 -0.34 2.61e-18 Total body bone mineral density; BRCA cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg06115741 chr20:33292138 TP53INP2 0.4 8.76 0.33 1.73e-17 Coronary artery disease; BRCA cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.62 0.42 1.93e-28 Homoarginine levels; BRCA cis rs1372520 0.684 rs356162 chr4:90697157 T/C cg15133208 chr4:90757351 SNCA 0.4 7.9 0.3 1.2e-14 Neuroticism; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg22907277 chr7:1156413 C7orf50 0.62 11.87 0.43 1.61e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg21856205 chr7:94953877 PON1 -0.37 -8.17 -0.31 1.68e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs3768617 0.565 rs3768626 chr1:183078462 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 18.01 0.58 5.66e-59 Fuchs's corneal dystrophy; BRCA cis rs3806843 0.966 rs3756341 chr5:140171194 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.8 -0.36 3.25e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg12011299 chr4:100065546 ADH4 0.48 11.18 0.4 1.28e-26 Alcohol dependence; BRCA cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -16.1 -0.54 3.4e-49 Chronic sinus infection; BRCA cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg22834771 chr12:69754056 YEATS4 -0.39 -9.64 -0.36 1.29e-20 Blood protein levels; BRCA cis rs11711311 1.000 rs13070720 chr3:113473754 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.77 -0.39 5.79e-25 IgG glycosylation; BRCA cis rs7020830 0.931 rs13293916 chr9:37136359 C/G cg14294708 chr9:37120828 ZCCHC7 1.19 42.07 0.86 2.61e-186 Schizophrenia; BRCA cis rs708547 0.647 rs781668 chr4:57825140 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.38 -9.56 -0.35 2.44e-20 Response to bleomycin (chromatid breaks); BRCA cis rs6940638 0.615 rs9393801 chr6:27242681 A/G cg12292205 chr6:26970375 C6orf41 -0.43 -8.74 -0.33 2.1e-17 Intelligence (multi-trait analysis); BRCA cis rs35146811 0.735 rs7811662 chr7:99792608 A/G cg13334819 chr7:99746414 C7orf59 -0.34 -7.9 -0.3 1.24e-14 Coronary artery disease; BRCA cis rs3925075 1.000 rs4411512 chr16:31347445 C/T cg02846316 chr16:31340340 ITGAM 0.54 13.29 0.47 9.24e-36 IgA nephropathy; BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg04267008 chr7:1944627 MAD1L1 -0.49 -10.91 -0.4 1.55e-25 Bipolar disorder and schizophrenia; BRCA cis rs7953508 0.506 rs1316740 chr12:93968288 C/A cg18151635 chr12:93972918 NA -0.46 -9.19 -0.34 5.6e-19 Pubertal anthropometrics; BRCA cis rs12922317 0.535 rs8051349 chr16:12105523 T/A cg09319797 chr16:12061715 TNFRSF17 -0.34 -7.94 -0.3 9.01e-15 Schizophrenia; BRCA cis rs2239547 0.563 rs4687560 chr3:52898121 T/G cg18404041 chr3:52824283 ITIH1 -0.31 -7.97 -0.3 7.1e-15 Schizophrenia; BRCA cis rs546131 0.928 rs547504 chr11:34847225 G/T cg06937548 chr11:34938143 PDHX;APIP 0.44 8.38 0.31 3.25e-16 Lung disease severity in cystic fibrosis; BRCA cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg10876282 chr6:28092338 ZSCAN16 0.42 8.38 0.31 3.25e-16 Cardiac Troponin-T levels; BRCA trans rs17685 0.671 rs10274404 chr7:75706634 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 28.37 0.75 3.37e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg02743256 chr7:2109353 MAD1L1 -0.45 -8.4 -0.32 2.8e-16 Bipolar disorder; BRCA cis rs78456975 0.574 rs13412980 chr2:1545231 C/A cg12573674 chr2:1569213 NA -0.58 -11.19 -0.4 1.14e-26 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs12618769 0.597 rs3754886 chr2:99107677 A/G cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg11845111 chr2:191398756 TMEM194B 0.4 9.29 0.35 2.32e-19 Pulse pressure; BRCA cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg17724175 chr1:150552817 MCL1 0.25 8.44 0.32 2.08e-16 Tonsillectomy; BRCA cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg26647111 chr11:31128758 NA 0.41 8.76 0.33 1.79e-17 Red blood cell count; BRCA cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg07148914 chr20:33460835 GGT7 0.42 9.26 0.34 3.04e-19 Height; BRCA trans rs2562456 0.917 rs2650805 chr19:21687939 T/G cg25042112 chr7:64838748 ZNF92 0.45 8.31 0.31 5.89e-16 Pain; BRCA cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg02503808 chr4:7069936 GRPEL1 -0.8 -14.14 -0.49 1.11e-39 Monocyte percentage of white cells; BRCA cis rs72772090 0.539 rs3334 chr5:96115085 G/C cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.16 -0.43 9.57e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg20503657 chr10:835505 NA 1.29 21.5 0.65 1.46e-77 Eosinophil percentage of granulocytes; BRCA cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10089 1.000 rs1842006 chr5:127508687 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.63 14.56 0.5 1.15e-41 Ileal carcinoids; BRCA cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg04455712 chr21:45112962 RRP1B -0.39 -9.48 -0.35 5.07e-20 Mean corpuscular volume; BRCA cis rs7103648 0.897 rs35032070 chr11:47408592 G/A cg03711944 chr11:47377212 SPI1 -0.47 -12.01 -0.43 4.14e-30 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -10.23 -0.38 7.41e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4423214 0.879 rs1790353 chr11:71136730 C/T cg05163923 chr11:71159392 DHCR7 -0.56 -11.24 -0.41 7.37e-27 Vitamin D levels; BRCA trans rs459571 0.959 rs392134 chr9:136909008 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.81 -15.44 -0.52 5.94e-46 Platelet distribution width; BRCA cis rs614226 0.744 rs787832 chr12:120986801 A/G cg27489772 chr12:121021490 NA 0.46 8.15 0.31 1.98e-15 Type 1 diabetes nephropathy; BRCA cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg27029518 chr18:72166324 CNDP2 -0.31 -8.68 -0.32 3.35e-17 Refractive error; BRCA cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg06784218 chr1:46089804 CCDC17 0.5 12.1 0.43 1.78e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg16586182 chr3:47516702 SCAP 0.55 12.35 0.44 1.44e-31 Colorectal cancer; BRCA cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg15017067 chr4:17643749 FAM184B 0.28 8.52 0.32 1.17e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17270561 0.636 rs6923367 chr6:25745852 A/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.18e-17 Iron status biomarkers; BRCA cis rs2108225 1.000 rs6466190 chr7:107451045 G/T cg18560240 chr7:107437656 SLC26A3 0.5 10.13 0.37 1.88e-22 Ulcerative colitis; BRCA cis rs2806561 0.765 rs681395 chr1:23500314 G/A cg12483005 chr1:23474871 LUZP1 0.47 10.47 0.38 8.71e-24 Height; BRCA trans rs6089829 0.962 rs6089825 chr20:61668447 C/T cg23505145 chr19:12996616 KLF1 0.54 12.43 0.44 6.62e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg06640241 chr16:89574553 SPG7 0.87 22.39 0.66 2.05e-82 Multiple myeloma (IgH translocation); BRCA cis rs870825 1.000 rs870825 chr4:185588045 A/G cg04058563 chr4:185651563 MLF1IP 0.78 13.36 0.47 4.56e-36 Blood protein levels; BRCA cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.96 25.16 0.71 1.37e-97 Subjective well-being; BRCA cis rs6087990 0.735 rs910083 chr20:31378690 A/C cg13636640 chr20:31349939 DNMT3B 0.64 18.0 0.58 6.89e-59 Ulcerative colitis; BRCA cis rs72772090 0.539 rs72773947 chr5:96125533 T/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs9291683 0.588 rs12507330 chr4:10002195 G/A cg26043149 chr18:55253948 FECH 0.38 8.63 0.32 4.97e-17 Bone mineral density; BRCA cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg13010199 chr12:38710504 ALG10B -0.37 -8.92 -0.33 4.97e-18 Morning vs. evening chronotype; BRCA cis rs9787249 0.957 rs1046988 chr1:40219065 A/G cg02773041 chr1:40204384 PPIE -0.44 -9.33 -0.35 1.68e-19 Blood protein levels; BRCA cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg22800045 chr5:56110881 MAP3K1 -0.47 -9.31 -0.35 1.95e-19 Initial pursuit acceleration; BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs11051970 0.661 rs188979 chr12:32569684 G/T cg02745156 chr12:32552066 NA 0.25 8.27 0.31 7.85e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11792861 0.926 rs75128146 chr9:111833791 G/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.18 0.31 1.48e-15 Menarche (age at onset); BRCA cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs12367572 0.663 rs1118481 chr12:45354469 C/G cg04608330 chr12:45269318 NELL2 -0.48 -10.26 -0.38 5.65e-23 Gut microbiome composition (summer); BRCA cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg13319975 chr6:146136371 FBXO30 -0.35 -8.11 -0.31 2.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg08999081 chr20:33150536 PIGU 0.47 12.95 0.46 3.17e-34 Glomerular filtration rate (creatinine); BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg07092213 chr7:1199455 ZFAND2A -0.37 -7.93 -0.3 9.54e-15 Longevity;Endometriosis; BRCA cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg11764359 chr7:65958608 NA -0.77 -17.63 -0.57 5.38e-57 Aortic root size; BRCA cis rs1003719 0.715 rs7277820 chr21:38580309 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.45 -0.5 3.7e-41 Eye color traits; BRCA cis rs55665837 1.000 rs4412729 chr11:14439000 A/G cg19336497 chr11:14380999 RRAS2 -0.34 -8.18 -0.31 1.52e-15 Vitamin D levels; BRCA cis rs1865760 1.000 rs3799372 chr6:25922311 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 11.35 0.41 2.61e-27 Height; BRCA cis rs17401966 0.931 rs3748579 chr1:10420937 C/T cg03954927 chr1:10346856 KIF1B 0.48 14.88 0.51 3.21e-43 Hepatocellular carcinoma; BRCA cis rs67981189 0.537 rs917067 chr14:71371904 C/T cg15816911 chr14:71606274 NA -0.39 -8.92 -0.33 4.79e-18 Schizophrenia; BRCA cis rs6835098 0.961 rs1574314 chr4:174106663 C/T cg08422745 chr4:174089978 GALNT7 -0.78 -15.97 -0.53 1.52e-48 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg11764359 chr7:65958608 NA -0.75 -16.53 -0.55 2.26e-51 Aortic root size; BRCA cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg14844989 chr11:31128820 NA -0.43 -9.56 -0.35 2.59e-20 Red blood cell count; BRCA cis rs1801251 0.727 rs6437071 chr2:233568793 G/A cg08000102 chr2:233561755 GIGYF2 0.63 14.58 0.5 8.97e-42 Coronary artery disease; BRCA cis rs7631605 0.935 rs6550448 chr3:37108896 T/A cg15934958 chr3:37212084 LRRFIP2 0.41 9.51 0.35 3.86e-20 Cerebrospinal P-tau181p levels; BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg20607798 chr8:58055168 NA 0.58 9.25 0.34 3.26e-19 Developmental language disorder (linguistic errors); BRCA cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg17330251 chr7:94953956 PON1 -0.41 -8.5 -0.32 1.35e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg00339695 chr16:24857497 SLC5A11 0.54 11.79 0.42 3.76e-29 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.36 -8.31 -0.31 5.9e-16 Longevity;Endometriosis; BRCA cis rs9462027 0.628 rs11759151 chr6:34747603 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.0 -0.3 5.77e-15 Systemic lupus erythematosus; BRCA cis rs6598955 0.671 rs11247909 chr1:26640135 G/A cg04990556 chr1:26633338 UBXN11 0.55 9.12 0.34 9.28e-19 Obesity-related traits; BRCA cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg14019146 chr3:50243930 SLC38A3 0.37 9.03 0.34 2.09e-18 Menarche (age at onset); BRCA cis rs7647973 1.000 rs9862534 chr3:49598064 A/G cg07636037 chr3:49044803 WDR6 0.69 14.23 0.49 3.95e-40 Menarche (age at onset); BRCA cis rs757081 0.636 rs214934 chr11:17193475 T/A cg15432903 chr11:17409602 KCNJ11 -0.45 -8.5 -0.32 1.33e-16 Systolic blood pressure; BRCA cis rs1882538 0.503 rs1345938 chr7:133137867 C/T cg10665199 chr7:133106180 EXOC4 -0.48 -10.12 -0.37 1.99e-22 Intelligence (multi-trait analysis); BRCA cis rs12612619 0.732 rs13032100 chr2:27233859 T/C cg00617064 chr2:27272375 NA -0.3 -7.97 -0.3 7.44e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs3806843 0.864 rs2531343 chr5:140129346 A/G cg11822812 chr5:140052017 DND1 -0.33 -8.96 -0.33 3.61e-18 Depressive symptoms (multi-trait analysis); BRCA cis rs10504073 0.584 rs7820270 chr8:49971395 G/T cg00325661 chr8:49890786 NA 0.42 12.27 0.44 3.32e-31 Blood metabolite ratios; BRCA cis rs9790314 0.967 rs7623206 chr3:160971518 G/A cg03342759 chr3:160939853 NMD3 -0.63 -13.33 -0.47 5.81e-36 Morning vs. evening chronotype; BRCA cis rs12579753 0.879 rs1987116 chr12:82156478 G/A cg07988820 chr12:82153109 PPFIA2 -0.67 -11.22 -0.41 8.97e-27 Resting heart rate; BRCA cis rs6545883 0.794 rs778152 chr2:61608540 C/A cg15711740 chr2:61764176 XPO1 0.53 13.52 0.47 7.87e-37 Tuberculosis; BRCA cis rs7640424 0.649 rs62262371 chr3:107896108 C/T cg09227934 chr3:107805635 CD47 -0.38 -7.88 -0.3 1.39e-14 Body mass index; BRCA trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg22968622 chr17:43663579 NA 1.13 19.43 0.61 2.1e-66 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs6570726 0.875 rs368744 chr6:145812622 A/G cg23711669 chr6:146136114 FBXO30 0.62 14.02 0.49 3.95e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg22800045 chr5:56110881 MAP3K1 -0.43 -8.44 -0.32 2.16e-16 Initial pursuit acceleration; BRCA cis rs2904967 0.852 rs1858783 chr11:65042941 A/G cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs113835537 0.735 rs519380 chr11:66409409 G/A cg24851651 chr11:66362959 CCS 0.49 8.13 0.31 2.2e-15 Airway imaging phenotypes; BRCA trans rs4718428 0.607 rs66954441 chr7:66369209 T/C cg18876405 chr7:65276391 NA 0.43 8.45 0.32 1.96e-16 Corneal structure; BRCA cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg16325326 chr1:53192061 ZYG11B -0.95 -25.95 -0.72 6.27e-102 Monocyte count; BRCA cis rs262150 0.714 rs2657397 chr7:158785095 C/T cg26536863 chr7:158807979 LOC154822 0.36 8.26 0.31 8.56e-16 Facial morphology (factor 20); BRCA cis rs1371867 0.846 rs1788205 chr8:101306546 G/C cg06636551 chr8:101224915 SPAG1 -0.38 -8.72 -0.33 2.39e-17 Atrioventricular conduction; BRCA cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg08859206 chr1:53392774 SCP2 -0.4 -8.63 -0.32 5e-17 Monocyte count; BRCA cis rs1048238 0.506 rs56352596 chr1:16297592 G/A cg21385522 chr1:16154831 NA 0.43 9.05 0.34 1.69e-18 Systolic blood pressure; BRCA cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg19077165 chr18:44547161 KATNAL2 -0.6 -13.5 -0.47 1.01e-36 Personality dimensions; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg04944784 chr2:26401820 FAM59B 1.0 16.75 0.55 1.77e-52 Gut microbiome composition (summer); BRCA cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg06115741 chr20:33292138 TP53INP2 -0.42 -9.35 -0.35 1.4e-19 Coronary artery disease; BRCA cis rs701145 0.643 rs357488 chr3:153885006 A/G cg17054900 chr3:154042577 DHX36 0.57 9.53 0.35 3.22e-20 Coronary artery disease; BRCA cis rs7762018 0.607 rs6907814 chr6:170058206 G/A cg19338460 chr6:170058176 WDR27 -0.77 -11.01 -0.4 6.26e-26 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg24110177 chr3:50126178 RBM5 -0.45 -9.93 -0.37 1.07e-21 Intelligence (multi-trait analysis); BRCA cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg15436174 chr10:43711423 RASGEF1A 0.5 9.96 0.37 7.74e-22 Hirschsprung disease; BRCA cis rs7914558 0.966 rs7921574 chr10:104840970 T/C cg04362960 chr10:104952993 NT5C2 0.42 10.18 0.37 1.22e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7246657 0.663 rs4803287 chr19:38079435 A/G cg14683738 chr19:37701593 ZNF585B 0.48 8.14 0.31 2.02e-15 Coronary artery calcification; BRCA cis rs1401999 1.000 rs13317532 chr3:183641669 G/C cg20387954 chr3:183756860 HTR3D 0.45 10.12 0.37 1.93e-22 Anterior chamber depth; BRCA cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 4.09e-29 Bipolar disorder; BRCA cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg05535760 chr7:792225 HEATR2 0.7 13.32 0.47 6.96e-36 Cerebrospinal P-tau181p levels; BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.15 0.34 7.49e-19 Tonsillectomy; BRCA cis rs965469 0.901 rs6037586 chr20:3368114 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -10.25 -0.38 6.11e-23 IFN-related cytopenia; BRCA cis rs416603 0.901 rs149597 chr16:11343942 C/G cg00044050 chr16:11439710 C16orf75 -0.41 -9.5 -0.35 4.08e-20 Type 1 diabetes; BRCA cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg04553112 chr3:125709451 NA -0.5 -8.11 -0.31 2.63e-15 Blood pressure (smoking interaction); BRCA cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg08917208 chr2:24149416 ATAD2B 0.91 13.46 0.47 1.5e-36 Lymphocyte counts; BRCA cis rs11190604 1.000 rs2489050 chr10:102350898 T/A cg07080220 chr10:102295463 HIF1AN 0.61 13.07 0.46 9.45e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg12310025 chr6:25882481 NA 0.55 12.07 0.43 2.38e-30 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg24642439 chr20:33292090 TP53INP2 -0.41 -8.44 -0.32 2.16e-16 Height; BRCA cis rs2288073 0.965 rs10173949 chr2:24410256 A/C cg06627628 chr2:24431161 ITSN2 -0.63 -12.02 -0.43 3.88e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs4642101 0.765 rs9871991 chr3:12827525 C/A cg05775895 chr3:12838266 CAND2 0.35 7.84 0.3 1.84e-14 QRS complex (12-leadsum); BRCA cis rs11711311 1.000 rs2566968 chr3:113474154 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.69 -0.39 1.22e-24 IgG glycosylation; BRCA cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.4 -0.32 2.87e-16 Monocyte percentage of white cells; BRCA cis rs7264396 0.790 rs6058297 chr20:34271861 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.38 7.97 0.3 7.13e-15 Total cholesterol levels; BRCA cis rs78707713 0.524 rs10823377 chr10:71213327 G/A cg12610070 chr10:71211762 TSPAN15 -0.26 -10.03 -0.37 4.48e-22 Venous thromboembolism; BRCA cis rs7249921 0.833 rs2285515 chr19:35660450 T/C cg15419183 chr19:35660584 FXYD5 0.46 10.26 0.38 5.53e-23 Platelet count; BRCA cis rs2404602 0.735 rs11632222 chr15:76712927 C/G cg23625390 chr15:77176239 SCAPER -0.52 -12.1 -0.43 1.75e-30 Blood metabolite levels; BRCA cis rs3768617 0.510 rs10752900 chr1:183086238 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 17.49 0.57 2.75e-56 Fuchs's corneal dystrophy; BRCA cis rs35110281 0.633 rs4819292 chr21:45125223 A/G cg04455712 chr21:45112962 RRP1B 0.46 12.18 0.43 7.92e-31 Mean corpuscular volume; BRCA cis rs847577 0.677 rs951988 chr7:97762474 C/G cg21770322 chr7:97807741 LMTK2 -0.46 -12.21 -0.44 5.54e-31 Breast cancer; BRCA cis rs11711311 1.000 rs16861312 chr3:113492402 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.38 0.41 1.81e-27 IgG glycosylation; BRCA cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg12292205 chr6:26970375 C6orf41 -0.59 -11.05 -0.4 4.14e-26 Intelligence (multi-trait analysis); BRCA cis rs9788682 0.747 rs12101809 chr15:78779801 C/T cg24631222 chr15:78858424 CHRNA5 0.46 9.06 0.34 1.6e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg22963979 chr7:1858916 MAD1L1 -0.4 -8.46 -0.32 1.77e-16 Bipolar disorder and schizophrenia; BRCA cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg11764359 chr7:65958608 NA -0.47 -9.11 -0.34 1.07e-18 Calcium levels; BRCA cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.03 0.3 4.76e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2712184 0.935 rs2712169 chr2:217671349 G/A cg05032264 chr2:217675019 NA -0.4 -9.83 -0.36 2.56e-21 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs17401966 1.000 rs60743860 chr1:10442926 G/C cg03954927 chr1:10346856 KIF1B 0.43 11.9 0.43 1.27e-29 Hepatocellular carcinoma; BRCA cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.21 -0.46 2.18e-35 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg26384229 chr12:38710491 ALG10B 0.75 17.25 0.56 4.78e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg22535103 chr8:58192502 C8orf71 -0.53 -9.09 -0.34 1.24e-18 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg04455712 chr21:45112962 RRP1B 0.39 9.9 0.36 1.36e-21 Mean corpuscular volume; BRCA cis rs11098499 0.865 rs10032158 chr4:120391632 C/T cg09307838 chr4:120376055 NA 0.76 16.36 0.54 1.61e-50 Corneal astigmatism; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg13047869 chr3:10149882 C3orf24 0.57 10.41 0.38 1.45e-23 Alzheimer's disease; BRCA cis rs7172677 1.000 rs4886422 chr15:75426723 C/T cg14664628 chr15:75095509 CSK -0.39 -8.1 -0.31 2.8e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.3 -0.35 2.22e-19 Bipolar disorder; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.21 -0.43 5.78e-31 Alzheimer's disease; BRCA cis rs9399135 0.967 rs9376085 chr6:135371224 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.46e-31 Red blood cell count; BRCA cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg24812749 chr6:127587940 RNF146 0.89 20.97 0.64 1.08e-74 Breast cancer; BRCA cis rs1476670 0.683 rs813642 chr1:44506420 A/C cg09470012 chr1:44509516 NA 0.42 9.29 0.34 2.4e-19 Eotaxin levels; BRCA cis rs3925075 0.531 rs4608351 chr16:31348848 T/C cg02846316 chr16:31340340 ITGAM 0.42 8.65 0.32 4.12e-17 IgA nephropathy; BRCA cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg10978503 chr1:24200527 CNR2 -0.42 -9.77 -0.36 4.13e-21 Immature fraction of reticulocytes; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.7 -0.42 8.41e-29 Lymphocyte counts; BRCA trans rs2018683 0.649 rs221193 chr7:29015784 G/T cg19402173 chr7:128379420 CALU -0.37 -8.13 -0.31 2.29e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA trans rs17685 0.702 rs6960598 chr7:75772991 T/C cg19862616 chr7:65841803 NCRNA00174 0.82 26.58 0.72 2.01e-105 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg16405210 chr4:1374714 KIAA1530 -0.49 -11.39 -0.41 1.71e-27 Longevity; BRCA cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg09065629 chr16:1709722 CRAMP1L 0.36 8.4 0.32 2.83e-16 Coronary artery disease; BRCA cis rs17270561 0.609 rs4711095 chr6:25726774 A/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg22875332 chr1:76189707 ACADM -0.69 -15.05 -0.51 4.97e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17384381 0.861 rs2300640 chr1:85823795 C/G cg16011679 chr1:85725395 C1orf52 0.53 8.12 0.31 2.34e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs12545109 0.800 rs2118261 chr8:57393286 A/G cg09654669 chr8:57350985 NA 0.37 7.96 0.3 8.04e-15 Obesity-related traits; BRCA cis rs4588572 0.570 rs2362832 chr5:77795843 A/G cg11547950 chr5:77652471 NA -0.49 -8.89 -0.33 6.42e-18 Triglycerides; BRCA cis rs9325144 0.647 rs7316392 chr12:39064381 T/G cg26384229 chr12:38710491 ALG10B -0.47 -10.87 -0.4 2.28e-25 Morning vs. evening chronotype; BRCA trans rs637571 0.726 rs669371 chr11:65674153 G/T cg17712092 chr4:129076599 LARP1B -0.67 -16.8 -0.55 9.9e-53 Eosinophil percentage of white cells; BRCA cis rs71386921 1 rs71386921 chr10:27478698 AAT/A cg14240646 chr10:27532245 ACBD5 -0.57 -9.61 -0.36 1.69e-20 Breast cancer; BRCA cis rs10791097 0.765 rs4622274 chr11:130729486 C/T cg09137382 chr11:130731461 NA 0.34 8.21 0.31 1.25e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg24642439 chr20:33292090 TP53INP2 -0.44 -9.06 -0.34 1.63e-18 Glomerular filtration rate (creatinine); BRCA cis rs9341808 0.718 rs10080237 chr6:80854470 T/C cg08355045 chr6:80787529 NA 0.37 9.29 0.35 2.32e-19 Sitting height ratio; BRCA cis rs17685 0.753 rs1637045 chr7:75703895 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.2 -0.31 1.33e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.87 0.3 1.55e-14 Tonsillectomy; BRCA cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg22431228 chr1:16359049 CLCNKA -0.49 -11.06 -0.4 3.96e-26 Systolic blood pressure; BRCA cis rs2070488 1.000 rs2268757 chr3:38505853 C/T cg24069376 chr3:38537580 EXOG 0.41 11.82 0.42 2.77e-29 Electrocardiographic conduction measures; BRCA cis rs6570726 0.935 rs384806 chr6:145814889 C/G cg23711669 chr6:146136114 FBXO30 0.64 15.05 0.51 4.81e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg21951975 chr1:209979733 IRF6 0.39 8.18 0.31 1.57e-15 Cleft lip with or without cleft palate; BRCA cis rs826838 1.000 rs826889 chr12:39101076 G/A cg26384229 chr12:38710491 ALG10B -0.64 -16.7 -0.55 3.26e-52 Heart rate; BRCA cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg03264133 chr6:25882463 NA -0.37 -8.31 -0.31 5.86e-16 Height; BRCA cis rs11583043 0.874 rs6577222 chr1:101420502 C/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.36 0.35 1.38e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs17376456 1.000 rs13163610 chr5:93548877 A/C cg25358565 chr5:93447407 FAM172A 1.14 18.27 0.59 2.57e-60 Diabetic retinopathy; BRCA cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg16339924 chr4:17578868 LAP3 -0.59 -14.21 -0.49 4.84e-40 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2599510 0.811 rs2710615 chr2:32791222 A/T cg02381751 chr2:32503542 YIPF4 0.42 8.39 0.31 3.17e-16 Interleukin-18 levels; BRCA cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.38 8.11 0.31 2.66e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.49 -8.91 -0.33 5.4e-18 Renal function-related traits (BUN); BRCA trans rs6582630 0.555 rs35284307 chr12:38509999 T/G cg06521331 chr12:34319734 NA -0.47 -8.73 -0.33 2.14e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs61931739 0.534 rs10844801 chr12:34230940 A/T cg06521331 chr12:34319734 NA -0.62 -11.38 -0.41 1.88e-27 Morning vs. evening chronotype; BRCA cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.33 0.31 4.75e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.95 -0.46 3.08e-34 Lymphocyte counts; BRCA cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -8.59 -0.32 6.42e-17 Schizophrenia; BRCA cis rs11758351 1.000 rs112751982 chr6:26191958 C/T cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg23533926 chr12:111358616 MYL2 -0.41 -8.57 -0.32 7.8e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.97 -18.12 -0.58 1.59e-59 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9858542 0.953 rs9858280 chr3:49597737 T/C cg03060546 chr3:49711283 APEH -0.53 -11.08 -0.4 3.1e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs12949688 0.967 rs12451753 chr17:55822214 T/A cg12582317 chr17:55822272 NA 0.32 7.93 0.3 9.97e-15 Schizophrenia; BRCA cis rs4718428 0.705 rs13220977 chr7:66337648 A/T cg18252515 chr7:66147081 NA 0.49 10.22 0.37 7.93e-23 Corneal structure; BRCA cis rs11690935 0.959 rs6759575 chr2:172689068 C/T cg13550731 chr2:172543902 DYNC1I2 -0.9 -29.55 -0.76 1.26e-121 Schizophrenia; BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.83 0.6 3.08e-63 Tonsillectomy; BRCA cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg13852791 chr20:30311386 BCL2L1 0.86 16.98 0.56 1.13e-53 Monocyte count; BRCA cis rs13102973 0.965 rs6853276 chr4:135881445 A/T cg14419869 chr4:135874104 NA 0.51 10.79 0.39 4.54e-25 Subjective well-being; BRCA cis rs8038465 0.594 rs55816897 chr15:73869767 G/T cg15420318 chr15:73925796 NPTN 0.46 10.57 0.39 3.71e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg18196295 chr10:418757 DIP2C 0.49 11.74 0.42 5.86e-29 Psychosis in Alzheimer's disease; BRCA cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24308560 chr3:49941425 MST1R 0.39 8.23 0.31 1.04e-15 Intelligence (multi-trait analysis); BRCA cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg14458575 chr2:238380390 NA -0.48 -11.05 -0.4 4.35e-26 Prostate cancer; BRCA cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg13319975 chr6:146136371 FBXO30 0.42 9.57 0.35 2.3e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs10927875 0.557 rs1572381 chr1:16344494 G/A cg22431228 chr1:16359049 CLCNKA -0.44 -9.95 -0.37 9.16e-22 Dilated cardiomyopathy; BRCA cis rs1868673 1.000 rs16862651 chr3:150157388 C/T cg04908077 chr3:150187338 NA -0.33 -9.0 -0.34 2.56e-18 Waist circumference; BRCA cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg01475377 chr6:109611718 NA -0.56 -15.22 -0.52 6.95e-45 Reticulocyte fraction of red cells; BRCA cis rs61931739 0.500 rs11053248 chr12:34518011 G/A cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg16586182 chr3:47516702 SCAP 0.53 11.4 0.41 1.62e-27 Colorectal cancer; BRCA cis rs10193935 1.000 rs12622910 chr2:42398918 C/A cg27598129 chr2:42591480 NA -0.92 -14.81 -0.51 7.13e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg01884057 chr2:25150051 NA 0.34 9.22 0.34 4.2e-19 Body mass index; BRCA cis rs4363385 0.597 rs6679201 chr1:152976840 C/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.78 -0.36 3.71e-21 Inflammatory skin disease; BRCA cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg26384229 chr12:38710491 ALG10B 0.75 17.51 0.57 2.3e-56 Bladder cancer; BRCA cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.69 0.32 3.12e-17 Personality dimensions; BRCA cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg00701064 chr4:6280414 WFS1 0.69 18.92 0.6 1.06e-63 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs34779708 0.931 rs12242882 chr10:35347860 G/C cg03585969 chr10:35415529 CREM 0.46 9.52 0.35 3.37e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12210905 0.610 rs72845208 chr6:27395664 C/A cg08851530 chr6:28072375 NA 0.81 7.95 0.3 8.51e-15 Hip circumference adjusted for BMI; BRCA cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg00530320 chr1:46809349 NSUN4 0.48 9.6 0.35 1.83e-20 Menopause (age at onset); BRCA cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg22431228 chr1:16359049 CLCNKA -0.45 -9.3 -0.35 2.11e-19 Dilated cardiomyopathy; BRCA cis rs17092148 1.000 rs6060047 chr20:33367400 G/T cg16810054 chr20:33298113 TP53INP2 0.48 10.86 0.39 2.43e-25 Neuroticism; BRCA cis rs7599312 0.534 rs2371615 chr2:213405660 G/T cg20637307 chr2:213403960 ERBB4 0.73 21.29 0.64 1.97e-76 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg24642439 chr20:33292090 TP53INP2 0.55 12.14 0.43 1.12e-30 Coronary artery disease; BRCA cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg18404041 chr3:52824283 ITIH1 0.42 12.48 0.44 3.87e-32 Bipolar disorder; BRCA cis rs6570726 1.000 rs444564 chr6:145859795 G/C cg23711669 chr6:146136114 FBXO30 0.64 14.96 0.51 1.34e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs11711311 0.784 rs13081931 chr3:113349928 G/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -9.12 -0.34 9.9e-19 IgG glycosylation; BRCA cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.41 0.61 2.5e-66 Alzheimer's disease; BRCA cis rs634534 0.622 rs593525 chr11:65727799 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.51 11.13 0.4 2.05e-26 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -9.0 -0.34 2.61e-18 Aortic root size; BRCA cis rs4588572 0.615 rs4143070 chr5:77769094 G/C cg11547950 chr5:77652471 NA -0.45 -8.63 -0.32 4.99e-17 Triglycerides; BRCA cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.87 0.56 4.31e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg09436375 chr6:42928200 GNMT -0.29 -10.78 -0.39 5.22e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs17376456 1.000 rs13174700 chr5:93554644 G/A cg25358565 chr5:93447407 FAM172A 1.17 18.34 0.59 1.17e-60 Diabetic retinopathy; BRCA cis rs701145 0.938 rs165275 chr3:153991875 T/C cg17054900 chr3:154042577 DHX36 0.68 11.76 0.42 4.97e-29 Coronary artery disease; BRCA cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg02038168 chr22:39784481 NA -0.43 -8.5 -0.32 1.31e-16 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.08 -0.3 3.26e-15 Total body bone mineral density; BRCA cis rs4363385 0.747 rs6689609 chr1:152967588 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.68 -0.36 9.02e-21 Inflammatory skin disease; BRCA cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg00409905 chr10:38381863 ZNF37A -0.48 -9.98 -0.37 6.6e-22 Extrinsic epigenetic age acceleration; BRCA cis rs7520050 0.778 rs2991985 chr1:46080530 T/C cg24296786 chr1:45957014 TESK2 0.48 11.5 0.41 5.88e-28 Red blood cell count;Reticulocyte count; BRCA cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg20203395 chr5:56204925 C5orf35 0.41 9.14 0.34 8.1e-19 Initial pursuit acceleration; BRCA cis rs7267979 1.000 rs2258617 chr20:25274318 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.7 0.36 7.47e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6545883 0.965 rs1562308 chr2:61768421 A/C cg15711740 chr2:61764176 XPO1 -0.56 -14.33 -0.49 1.35e-40 Tuberculosis; BRCA cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg13010199 chr12:38710504 ALG10B -0.41 -8.75 -0.33 1.94e-17 Morning vs. evening chronotype; BRCA cis rs9463078 0.547 rs764396 chr6:44710691 C/G cg25276700 chr6:44698697 NA 0.36 8.18 0.31 1.56e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.59 0.47 3.93e-37 Platelet count; BRCA cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg00071950 chr4:10020882 SLC2A9 -0.53 -12.59 -0.45 1.2e-32 Bone mineral density; BRCA cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg03517284 chr6:25882590 NA -0.49 -10.29 -0.38 4.27e-23 Intelligence (multi-trait analysis); BRCA cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg24450063 chr1:156163899 SLC25A44 1.08 32.41 0.79 5.16e-137 Testicular germ cell tumor; BRCA cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg04586622 chr2:25135609 ADCY3 0.46 11.38 0.41 1.91e-27 Body mass index; BRCA cis rs11098499 0.863 rs3736115 chr4:120488703 A/G cg09307838 chr4:120376055 NA -0.7 -14.33 -0.49 1.3e-40 Corneal astigmatism; BRCA cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.32 0.31 5.33e-16 Aortic root size; BRCA cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg00071950 chr4:10020882 SLC2A9 0.63 15.54 0.52 1.97e-46 Bone mineral density; BRCA cis rs2839186 0.587 rs35679325 chr21:47640980 A/G cg12516959 chr21:47718080 NA 0.33 7.84 0.3 1.94e-14 Testicular germ cell tumor; BRCA cis rs2777491 0.915 rs16971767 chr15:41623308 T/C cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.93 -0.48 1.09e-38 Ulcerative colitis; BRCA cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.05 0.34 1.7e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7572263 0.724 rs7579275 chr2:209053080 A/C cg23998903 chr2:209048830 C2orf80 -0.42 -8.78 -0.33 1.52e-17 Glioma;Non-glioblastoma glioma; BRCA trans rs9650657 0.537 rs11250092 chr8:10786543 A/G cg06636001 chr8:8085503 FLJ10661 0.52 10.93 0.4 1.31e-25 Neuroticism; BRCA cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.97 19.95 0.62 3.16e-69 Cognitive ability; BRCA cis rs11229555 0.609 rs11229451 chr11:58201687 T/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg01884057 chr2:25150051 NA 0.34 9.22 0.34 4.2e-19 Body mass index; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg08888203 chr3:10149979 C3orf24 -0.66 -14.15 -0.49 9.55e-40 Alzheimer's disease; BRCA trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg11887960 chr12:57824829 NA -0.5 -8.19 -0.31 1.46e-15 Obesity-related traits; BRCA cis rs2522056 0.935 rs1981524 chr5:131756506 C/T cg24060327 chr5:131705240 SLC22A5 0.5 8.66 0.32 3.88e-17 Lymphocyte counts;Fibrinogen; BRCA cis rs909002 0.789 rs3817398 chr1:32119431 C/T cg13919466 chr1:32135498 COL16A1 0.25 8.35 0.31 4.4e-16 Intelligence (multi-trait analysis); BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg23283495 chr1:209979779 IRF6 0.42 13.42 0.47 2.34e-36 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs910316 0.687 rs175059 chr14:75490667 T/C cg11812906 chr14:75593930 NEK9 -0.64 -14.79 -0.5 9.24e-43 Height; BRCA cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg16230307 chr14:35515116 FAM177A1 0.75 15.49 0.52 3.35e-46 Psoriasis; BRCA trans rs2197308 0.740 rs1842595 chr12:37906223 G/A cg06521331 chr12:34319734 NA 0.45 8.89 0.33 6.03e-18 Morning vs. evening chronotype; BRCA cis rs312274 0.532 rs312276 chr12:41243143 A/G cg17827154 chr12:41323612 CNTN1 0.36 8.83 0.33 1.03e-17 Metabolite levels (X-11787); BRCA cis rs2635047 0.935 rs2576031 chr18:44658146 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 8.62 0.32 5.33e-17 Educational attainment; BRCA trans rs7615952 0.512 rs1077621 chr3:125819799 A/G cg07211511 chr3:129823064 LOC729375 -0.63 -10.91 -0.4 1.51e-25 Blood pressure (smoking interaction); BRCA cis rs8062405 1.000 rs9972693 chr16:28859802 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6752107 0.935 rs11688431 chr2:234147175 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 10.61 0.39 2.4e-24 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1215050 0.740 rs1648568 chr4:98957619 A/G cg05340658 chr4:99064831 C4orf37 -0.49 -11.42 -0.41 1.32e-27 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1784581 0.894 rs1626020 chr6:162383379 G/A cg17173639 chr6:162384350 PARK2 -0.45 -10.72 -0.39 9.15e-25 Itch intensity from mosquito bite; BRCA cis rs12711979 0.509 rs12711972 chr2:3823786 T/C cg17052675 chr2:3827356 NA -0.7 -23.81 -0.69 3.44e-90 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs6547741 0.935 rs4260197 chr2:27794150 C/G cg27432699 chr2:27873401 GPN1 -0.46 -9.75 -0.36 5.04e-21 Oral cavity cancer; BRCA cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg07414643 chr4:187882934 NA 0.28 9.67 0.36 9.82e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg21782813 chr7:2030301 MAD1L1 0.35 9.24 0.34 3.66e-19 Bipolar disorder and schizophrenia; BRCA cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg15485101 chr11:133734466 NA 0.4 9.59 0.35 1.93e-20 Childhood ear infection; BRCA cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg23029597 chr12:123009494 RSRC2 -0.62 -12.72 -0.45 3.37e-33 Body mass index; BRCA cis rs7617773 0.817 rs11130162 chr3:48297611 A/G cg11946769 chr3:48343235 NME6 0.5 11.26 0.41 5.79e-27 Coronary artery disease; BRCA cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg26384229 chr12:38710491 ALG10B 0.77 17.57 0.57 1.14e-56 Bladder cancer; BRCA trans rs2270927 0.510 rs246813 chr5:75599605 G/T cg13563193 chr19:33072644 PDCD5 0.84 10.05 0.37 3.68e-22 Mean corpuscular volume; BRCA trans rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.36 8.06 0.3 3.87e-15 Endometrial cancer; BRCA cis rs9937943 0.721 rs8059315 chr16:74506447 C/G cg01733217 chr16:74700730 RFWD3 0.47 7.85 0.3 1.8e-14 Neutrophil percentage of white cells; BRCA cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.7e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.28e-36 Developmental language disorder (linguistic errors); BRCA trans rs6582630 0.555 rs12372536 chr12:38400864 C/G cg06521331 chr12:34319734 NA -0.46 -8.48 -0.32 1.58e-16 Drug-induced liver injury (flucloxacillin); BRCA trans rs1997103 1.000 rs4948011 chr7:55403859 A/G cg20935933 chr6:143382018 AIG1 0.59 11.37 0.41 2.04e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs3760982 0.585 rs67704568 chr19:44294019 T/C cg11993925 chr19:44307056 LYPD5 0.38 8.91 0.33 5.4e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs6542838 0.641 rs12478574 chr2:99476369 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.37 -8.34 -0.31 4.66e-16 Fear of minor pain; BRCA cis rs7590720 0.704 rs7603645 chr2:216876949 C/G cg12620499 chr2:216877984 MREG 0.81 26.45 0.72 1.02e-104 Alcohol dependence; BRCA cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg24642439 chr20:33292090 TP53INP2 0.52 11.42 0.41 1.23e-27 Glomerular filtration rate (creatinine); BRCA cis rs74181299 0.684 rs6741255 chr2:65306905 C/T cg05010058 chr2:65284262 CEP68 -0.3 -7.98 -0.3 6.57e-15 Pulse pressure; BRCA cis rs2288073 0.801 rs6757275 chr2:24375230 A/G cg06627628 chr2:24431161 ITSN2 -0.53 -10.35 -0.38 2.52e-23 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -9.23 -0.34 3.87e-19 Monocyte percentage of white cells; BRCA cis rs1580019 0.885 rs4460270 chr7:32496450 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.73 15.87 0.53 4.42e-48 Cognitive ability; BRCA trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg15934090 chr1:100435551 SLC35A3 0.35 7.91 0.3 1.11e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg11833968 chr6:79620685 NA 0.43 9.44 0.35 6.68e-20 Intelligence (multi-trait analysis); BRCA cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg00074818 chr8:8560427 CLDN23 0.37 8.16 0.31 1.78e-15 Obesity-related traits; BRCA cis rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05901451 chr6:126070800 HEY2 -0.41 -10.08 -0.37 2.73e-22 Endometrial cancer; BRCA cis rs7592578 0.882 rs58568707 chr2:191468987 G/A cg10560079 chr2:191398806 TMEM194B -0.71 -12.48 -0.44 3.92e-32 Diastolic blood pressure; BRCA trans rs1997103 1.000 rs6973450 chr7:55396537 A/G cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.62 -0.36 1.44e-20 Alzheimer's disease (late onset); BRCA cis rs6893300 0.961 rs62406219 chr5:179211629 G/A cg14593053 chr5:179126677 CANX -0.37 -8.03 -0.3 4.61e-15 Resting heart rate; BRCA cis rs16854884 0.657 rs6766685 chr3:143736916 C/T cg06585982 chr3:143692056 C3orf58 0.43 8.99 0.33 2.87e-18 Economic and political preferences (feminism/equality); BRCA cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg12386194 chr3:101231763 SENP7 0.46 9.79 0.36 3.64e-21 Colorectal cancer; BRCA cis rs13217239 0.646 rs11756275 chr6:27007113 A/C cg12292205 chr6:26970375 C6orf41 -0.58 -12.71 -0.45 3.79e-33 Schizophrenia; BRCA cis rs7520050 0.966 rs6695809 chr1:46285461 T/C cg24296786 chr1:45957014 TESK2 0.43 9.8 0.36 3.18e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2652834 0.950 rs2652815 chr15:63401345 T/C cg05507819 chr15:63340323 TPM1 0.45 8.05 0.3 3.97e-15 HDL cholesterol; BRCA trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.62 0.36 1.5e-20 Morning vs. evening chronotype; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg22907277 chr7:1156413 C7orf50 0.59 9.28 0.34 2.7e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg22535103 chr8:58192502 C8orf71 -0.49 -8.66 -0.32 3.91e-17 Developmental language disorder (linguistic errors); BRCA cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.58 -13.08 -0.46 8.49e-35 Platelet count; BRCA trans rs12517041 1.000 rs2099090 chr5:23287823 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs7903847 0.642 rs1048442 chr10:99160152 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.5 -0.32 1.38e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.66 9.98 0.37 6.49e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.54 0.77 5.46e-127 Chronic sinus infection; BRCA cis rs6433895 1.000 rs13025711 chr2:182019461 A/G cg00481216 chr2:181971175 NA 0.39 9.15 0.34 7.59e-19 Lymphocyte counts; BRCA cis rs1371867 0.846 rs1660327 chr8:101292206 A/C cg06002616 chr8:101225028 SPAG1 -0.34 -8.3 -0.31 6.4e-16 Atrioventricular conduction; BRCA cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg02880119 chr16:3481970 NA 0.54 9.64 0.36 1.21e-20 Body mass index (adult); BRCA cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg19077165 chr18:44547161 KATNAL2 -0.52 -10.98 -0.4 7.85e-26 Personality dimensions; BRCA cis rs8032158 1.000 rs11633263 chr15:56135559 A/C cg02198044 chr15:56286336 NEDD4 -0.37 -8.9 -0.33 5.7e-18 Keloid; BRCA cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11890956 chr21:40555474 PSMG1 -0.81 -19.34 -0.61 6.08e-66 Cognitive function; BRCA cis rs36051895 0.530 rs4142064 chr9:5221818 C/T cg02405213 chr9:5042618 JAK2 -0.44 -8.37 -0.31 3.59e-16 Pediatric autoimmune diseases; BRCA cis rs274567 0.501 rs274571 chr5:131712125 A/G cg07395648 chr5:131743802 NA 0.38 8.23 0.31 1.02e-15 Blood metabolite levels; BRCA cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11644478 chr21:40555479 PSMG1 0.81 18.1 0.58 1.96e-59 Cognitive function; BRCA cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg08917208 chr2:24149416 ATAD2B 0.51 8.06 0.3 3.73e-15 Asthma; BRCA cis rs7258465 1.000 rs7252848 chr19:18612351 C/G cg01065977 chr19:18549689 ISYNA1 -0.3 -8.83 -0.33 9.65e-18 Breast cancer; BRCA cis rs6598955 0.616 rs11247890 chr1:26590182 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.31 -0.31 5.82e-16 Obesity-related traits; BRCA cis rs2066819 1.000 rs74673257 chr12:56638077 T/C cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA trans rs61931739 0.635 rs1486884 chr12:33908876 A/T cg13010199 chr12:38710504 ALG10B -0.36 -7.83 -0.3 2.05e-14 Morning vs. evening chronotype; BRCA cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg06697600 chr4:7070879 GRPEL1 -0.53 -10.82 -0.39 3.57e-25 Monocyte percentage of white cells; BRCA cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.35 0.41 2.57e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -13.7 -0.48 1.18e-37 Menarche (age at onset); BRCA cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg21132104 chr15:45694354 SPATA5L1 0.74 16.46 0.55 5.36e-51 Homoarginine levels; BRCA cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg21535247 chr6:8435926 SLC35B3 0.42 9.48 0.35 5.1e-20 Motion sickness; BRCA cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg19274703 chr22:41806451 NA 0.36 8.99 0.34 2.76e-18 Vitiligo; BRCA cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.55 -0.47 5.94e-37 Developmental language disorder (linguistic errors); BRCA cis rs965469 0.779 rs6051693 chr20:3244449 T/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.73 -0.33 2.27e-17 IFN-related cytopenia; BRCA cis rs12681288 0.550 rs58295701 chr8:962136 T/C cg04851639 chr8:1020857 NA -0.32 -8.82 -0.33 1.05e-17 Schizophrenia; BRCA cis rs990171 0.607 rs3917246 chr2:102775164 T/C cg22835712 chr2:102737379 NA 0.53 8.96 0.33 3.61e-18 Lymphocyte counts; BRCA cis rs11711311 1.000 rs2603793 chr3:113496418 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.2 -0.37 9.64e-23 IgG glycosylation; BRCA cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg17971929 chr21:40555470 PSMG1 0.77 18.03 0.58 4.67e-59 Cognitive function; BRCA cis rs6901250 0.632 rs339355 chr6:117196503 A/T cg12892004 chr6:117198278 RFX6 -0.39 -9.62 -0.36 1.53e-20 C-reactive protein levels; BRCA cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg21770322 chr7:97807741 LMTK2 0.42 11.18 0.4 1.21e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg16606324 chr3:10149918 C3orf24 0.56 11.01 0.4 5.91e-26 Alzheimer's disease; BRCA trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21659725 chr3:3221576 CRBN -0.47 -11.99 -0.43 5.23e-30 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs7647973 0.922 rs7620024 chr3:49451691 G/A cg07636037 chr3:49044803 WDR6 -0.73 -15.81 -0.53 9.22e-48 Menarche (age at onset); BRCA cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.8 -0.36 3.31e-21 IgG glycosylation; BRCA cis rs7267979 0.873 rs6083853 chr20:25404541 T/C cg08601574 chr20:25228251 PYGB -0.38 -8.86 -0.33 7.62e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10751667 0.580 rs7395515 chr11:1005160 C/T cg01483505 chr11:975446 AP2A2 0.3 8.17 0.31 1.63e-15 Alzheimer's disease (late onset); BRCA cis rs11112613 0.653 rs59504344 chr12:105950837 C/T cg03607813 chr12:105948248 NA 0.58 11.02 0.4 5.68e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs7647973 1.000 rs2177268 chr3:49439725 A/T cg07636037 chr3:49044803 WDR6 -0.73 -15.84 -0.53 6.49e-48 Menarche (age at onset); BRCA cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.3 0.31 6.32e-16 Autism spectrum disorder or schizophrenia; BRCA trans rs11165623 0.715 rs1980769 chr1:96888201 A/T cg10631902 chr5:14652156 NA -0.5 -16.09 -0.54 3.83e-49 Hip circumference;Waist circumference; BRCA cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg05775895 chr3:12838266 CAND2 0.36 8.14 0.31 2.07e-15 QRS complex (12-leadsum); BRCA trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg00717180 chr2:96193071 NA 0.31 8.66 0.32 3.73e-17 Coronary artery disease; BRCA cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11644478 chr21:40555479 PSMG1 0.85 19.56 0.61 4.1e-67 Cognitive function; BRCA cis rs7586879 0.765 rs6545758 chr2:25074874 C/T cg04586622 chr2:25135609 ADCY3 -0.34 -8.19 -0.31 1.44e-15 Body mass index; BRCA cis rs6570726 0.764 rs9403726 chr6:145901686 G/T cg23711669 chr6:146136114 FBXO30 0.72 17.24 0.56 5.44e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs7149337 0.836 rs4901087 chr14:51668499 T/C cg23942311 chr14:51606299 NA 0.43 12.12 0.43 1.37e-30 Cancer; BRCA cis rs4713118 0.629 rs203888 chr6:28021589 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 8.14 0.31 2.06e-15 Parkinson's disease; BRCA cis rs9527 0.571 rs12219246 chr10:104613355 A/G cg04362960 chr10:104952993 NT5C2 0.42 10.05 0.37 3.54e-22 Arsenic metabolism; BRCA cis rs6121246 0.559 rs6087782 chr20:30391580 C/T cg21427119 chr20:30132790 HM13 -0.36 -8.13 -0.31 2.28e-15 Mean corpuscular hemoglobin; BRCA cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.64 -0.36 1.26e-20 Tonsillectomy; BRCA cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg08999081 chr20:33150536 PIGU 0.36 9.08 0.34 1.33e-18 Coronary artery disease; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2806561 0.765 rs641808 chr1:23514123 T/G cg12483005 chr1:23474871 LUZP1 0.44 9.89 0.36 1.43e-21 Height; BRCA cis rs965469 0.652 rs6051837 chr20:3388994 G/T cg25506879 chr20:3388711 C20orf194 -0.48 -9.9 -0.36 1.31e-21 IFN-related cytopenia; BRCA cis rs10751667 0.580 rs7395515 chr11:1005160 C/T cg06064525 chr11:970664 AP2A2 -0.29 -8.7 -0.33 2.88e-17 Alzheimer's disease (late onset); BRCA cis rs9814567 1.000 rs9856693 chr3:134306913 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10751667 0.666 rs7105477 chr11:964271 C/G ch.11.42038R chr11:967971 AP2A2 0.51 16.14 0.54 2.02e-49 Alzheimer's disease (late onset); BRCA cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg03425785 chr20:62221387 GMEB2 0.51 8.25 0.31 9.21e-16 Glioblastoma; BRCA cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg02734326 chr4:10020555 SLC2A9 0.39 8.46 0.32 1.78e-16 Bone mineral density; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg22764044 chr5:178986830 RUFY1 -0.49 -13.87 -0.48 2.03e-38 Lung cancer; BRCA cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg05985134 chr18:33552581 C18orf21 0.71 13.62 0.47 2.99e-37 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9811920 0.809 rs902159 chr3:99747445 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 12.96 0.46 2.99e-34 Axial length; BRCA cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.54 0.35 2.89e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg26384229 chr12:38710491 ALG10B -0.5 -13.14 -0.46 4.29e-35 Morning vs. evening chronotype; BRCA cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg19717773 chr7:2847554 GNA12 -0.43 -9.73 -0.36 5.94e-21 Height; BRCA cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg15103426 chr22:29168792 CCDC117 0.54 12.57 0.45 1.56e-32 Lymphocyte counts; BRCA cis rs7264396 0.635 rs6060682 chr20:34506331 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.95 -0.51 1.54e-43 Total cholesterol levels; BRCA cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg19748678 chr4:122722346 EXOSC9 0.71 15.2 0.52 9.39e-45 Type 2 diabetes; BRCA cis rs11252926 0.625 rs7903876 chr10:482678 T/C cg03684893 chr10:554711 DIP2C 0.41 9.99 0.37 6.23e-22 Psychosis in Alzheimer's disease; BRCA cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg05340658 chr4:99064831 C4orf37 0.61 14.41 0.5 5.65e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg04267008 chr7:1944627 MAD1L1 -0.66 -13.97 -0.48 6.67e-39 Bipolar disorder and schizophrenia; BRCA cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg17105886 chr17:28927953 LRRC37B2 -0.59 -8.32 -0.31 5.14e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg14728415 chr7:32535168 LSM5;AVL9 0.36 7.97 0.3 7.3e-15 Cognitive ability; BRCA cis rs7246657 0.663 rs9304568 chr19:38054508 C/A cg23950597 chr19:37808831 NA -0.49 -8.52 -0.32 1.14e-16 Coronary artery calcification; BRCA cis rs2235642 0.653 rs7197288 chr16:1654753 C/A cg26528668 chr16:1614120 IFT140 0.36 7.9 0.3 1.23e-14 Coronary artery disease; BRCA cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg04756594 chr16:24857601 SLC5A11 0.5 11.57 0.42 3.07e-28 Intelligence (multi-trait analysis); BRCA cis rs936229 0.813 rs1350193 chr15:75084281 G/C cg14664628 chr15:75095509 CSK -0.93 -27.07 -0.73 4.18e-108 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA trans rs561341 1.000 rs501957 chr17:30314504 C/T cg20587970 chr11:113659929 NA -1.12 -20.23 -0.62 1.11e-70 Hip circumference adjusted for BMI; BRCA cis rs2070488 0.761 rs6807940 chr3:38460062 C/G cg24069376 chr3:38537580 EXOG 0.29 7.91 0.3 1.1e-14 Electrocardiographic conduction measures; BRCA cis rs7766436 0.922 rs11753523 chr6:22602094 G/A cg13666174 chr6:22585274 NA -0.42 -9.16 -0.34 7.25e-19 Coronary artery disease; BRCA cis rs2304069 0.954 rs2340463 chr5:149409294 C/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.54 8.29 0.31 6.62e-16 HIV-1 control; BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg00814883 chr7:100076585 TSC22D4 -0.54 -11.83 -0.42 2.56e-29 Platelet count; BRCA cis rs921968 0.509 rs7571743 chr2:219352572 C/T cg02176678 chr2:219576539 TTLL4 0.46 11.67 0.42 1.14e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs68170813 0.641 rs12538848 chr7:106984569 G/T cg02696742 chr7:106810147 HBP1 -0.5 -8.06 -0.3 3.74e-15 Coronary artery disease; BRCA cis rs10193935 0.901 rs222471 chr2:42638057 C/T cg27598129 chr2:42591480 NA 0.84 14.12 0.49 1.31e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 0.755 rs4787456 chr16:28559573 C/T cg16576597 chr16:28551801 NUPR1 0.36 9.68 0.36 8.82e-21 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg08975724 chr8:8085496 FLJ10661 0.47 10.06 0.37 3.38e-22 Mood instability; BRCA trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.88 -0.3 1.41e-14 Corneal astigmatism; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18758796 chr5:131593413 PDLIM4 0.35 9.28 0.34 2.52e-19 Breast cancer; BRCA cis rs3849570 1.000 rs9818006 chr3:81828230 A/C cg07356753 chr3:81810745 GBE1 -0.43 -10.28 -0.38 4.65e-23 Waist circumference;Body mass index; BRCA cis rs910316 0.935 rs175448 chr14:75591071 G/A cg23033748 chr14:75592666 NEK9 -0.43 -10.61 -0.39 2.43e-24 Height; BRCA cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg13770153 chr20:60521292 NA -0.35 -8.1 -0.3 2.89e-15 Body mass index; BRCA cis rs751728 0.664 rs943475 chr6:33749978 C/T cg25922239 chr6:33757077 LEMD2 -0.5 -12.68 -0.45 4.83e-33 Crohn's disease; BRCA cis rs2637030 0.559 rs549131 chr5:52902238 T/C cg06476337 chr5:52856530 NDUFS4 0.37 8.53 0.32 1.09e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA trans rs4332037 0.901 rs7791299 chr7:1935598 T/C cg11693508 chr17:37793320 STARD3 0.38 7.87 0.3 1.47e-14 Bipolar disorder; BRCA cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg08999081 chr20:33150536 PIGU 0.35 9.04 0.34 1.78e-18 Coronary artery disease; BRCA cis rs1776421 0.760 rs61768412 chr1:53901450 C/G cg10892335 chr1:53966318 NA 0.47 7.86 0.3 1.68e-14 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 8.24 0.31 9.46e-16 Electroencephalogram traits; BRCA cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.05 0.4 4.42e-26 Bipolar disorder; BRCA cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg12292205 chr6:26970375 C6orf41 -0.81 -19.89 -0.62 7.21e-69 Autism spectrum disorder or schizophrenia; BRCA cis rs7572733 0.534 rs770657 chr2:198674184 C/A cg00792783 chr2:198669748 PLCL1 0.47 10.22 0.37 8.54e-23 Dermatomyositis; BRCA cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg00701064 chr4:6280414 WFS1 0.71 19.23 0.61 2.26e-65 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4808199 0.894 rs10418051 chr19:19397789 C/T cg03709012 chr19:19516395 GATAD2A 0.88 16.52 0.55 2.57e-51 Nonalcoholic fatty liver disease; BRCA cis rs365132 0.875 rs353477 chr5:176418927 C/T cg16309518 chr5:176445507 NA -0.4 -9.73 -0.36 5.73e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA trans rs35110281 0.807 rs1598206 chr21:45058776 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.28 0.31 7.37e-16 Mean corpuscular volume; BRCA cis rs2425143 1.000 rs74785978 chr20:34373234 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.17 -0.34 6.32e-19 Blood protein levels; BRCA cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg18876405 chr7:65276391 NA -0.51 -11.43 -0.41 1.13e-27 Aortic root size; BRCA cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg25174290 chr11:3078921 CARS -0.3 -7.87 -0.3 1.54e-14 Calcium levels; BRCA cis rs7927592 0.913 rs6591344 chr11:68360873 G/A cg20283391 chr11:68216788 NA -0.45 -8.93 -0.33 4.39e-18 Total body bone mineral density; BRCA cis rs6142102 0.961 rs1319363 chr20:32541876 T/A cg24642439 chr20:33292090 TP53INP2 0.44 8.35 0.31 4.09e-16 Skin pigmentation; BRCA cis rs1595825 0.891 rs74965164 chr2:198499162 C/T cg19156104 chr2:198669113 PLCL1 -0.42 -8.14 -0.31 2.02e-15 Ulcerative colitis; BRCA cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.18 -0.31 1.59e-15 Colorectal cancer; BRCA cis rs11190604 0.697 rs12355942 chr10:102201320 T/C cg07080220 chr10:102295463 HIF1AN -0.5 -11.85 -0.42 1.95e-29 Palmitoleic acid (16:1n-7) levels; BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg01262667 chr19:19385393 TM6SF2 0.38 9.71 0.36 6.68e-21 Tonsillectomy; BRCA cis rs28735056 1.000 rs28735056 chr18:77622879 A/G cg20368463 chr18:77673604 PQLC1 -0.33 -8.05 -0.3 4.18e-15 Schizophrenia; BRCA cis rs11190604 1.000 rs3750630 chr10:102275780 A/G cg07080220 chr10:102295463 HIF1AN 0.6 14.17 0.49 7.71e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg26116260 chr4:7069785 GRPEL1 -0.9 -19.55 -0.61 4.37e-67 Monocyte percentage of white cells; BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.47 9.49 0.35 4.36e-20 Lymphocyte counts; BRCA cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.21 0.37 9.15e-23 Aortic root size; BRCA cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg25174290 chr11:3078921 CARS -0.3 -7.87 -0.3 1.54e-14 Calcium levels; BRCA cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg24675658 chr1:53192096 ZYG11B -0.6 -13.8 -0.48 4.01e-38 Monocyte count; BRCA trans rs61931739 0.635 rs1405025 chr12:33908491 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.24 0.34 3.74e-19 Morning vs. evening chronotype; BRCA cis rs523522 1.000 rs523522 chr12:121020250 A/T cg27279351 chr12:120934652 DYNLL1 0.55 13.12 0.46 5.72e-35 High light scatter reticulocyte count; BRCA cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg25767906 chr1:53392781 SCP2 0.37 8.6 0.32 5.92e-17 Monocyte count; BRCA cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -8.48 -0.32 1.57e-16 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg07148914 chr20:33460835 GGT7 -0.37 -7.97 -0.3 7.47e-15 Glomerular filtration rate (creatinine); BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg04166393 chr7:2884313 GNA12 0.51 9.62 0.36 1.5e-20 Height; BRCA cis rs921968 0.643 rs559722 chr2:219398159 A/G cg02176678 chr2:219576539 TTLL4 0.39 10.48 0.38 7.73e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs17253792 0.822 rs75991559 chr14:56092419 A/T cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs701145 0.585 rs401162 chr3:153905988 T/A cg17054900 chr3:154042577 DHX36 0.58 9.66 0.36 1.1e-20 Coronary artery disease; BRCA cis rs921968 0.541 rs3845835 chr2:219342284 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -12.82 -0.45 1.24e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs6977660 0.714 rs10249477 chr7:19805388 T/A cg05791153 chr7:19748676 TWISTNB 0.59 10.83 0.39 3.39e-25 Thyroid stimulating hormone; BRCA cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg00990874 chr7:1149470 C7orf50 -0.53 -9.83 -0.36 2.46e-21 Bronchopulmonary dysplasia; BRCA trans rs783540 0.934 rs1594511 chr15:83307063 T/A cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.23 -0.31 1.04e-15 Schizophrenia; BRCA cis rs9868809 0.505 rs56735597 chr3:48765168 A/G cg00383909 chr3:49044727 WDR6 0.63 11.23 0.41 7.62e-27 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg04476341 chr5:669733 TPPP 0.39 7.86 0.3 1.65e-14 Lung disease severity in cystic fibrosis; BRCA cis rs897080 0.552 rs1067326 chr2:44628605 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.35 0.35 1.46e-19 Height; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg18402987 chr7:1209562 NA 0.4 8.18 0.31 1.53e-15 Longevity;Endometriosis; BRCA cis rs11711311 1.000 rs34475696 chr3:113458293 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs11792861 0.781 rs28361106 chr9:111762385 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.93 0.3 9.62e-15 Menarche (age at onset); BRCA cis rs344364 0.511 rs337284 chr16:1954799 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.5 -9.15 -0.34 7.65e-19 Glomerular filtration rate in chronic kidney disease; BRCA cis rs11971779 0.941 rs74299967 chr7:139043769 G/T cg07862535 chr7:139043722 LUC7L2 0.53 12.98 0.46 2.21e-34 Diisocyanate-induced asthma; BRCA cis rs3784262 0.669 rs7178598 chr15:58309016 C/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.03 -0.37 4.41e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7903847 0.667 rs11189181 chr10:99144154 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.01 -0.3 5.35e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg20933634 chr6:27740509 NA 0.43 8.5 0.32 1.35e-16 Parkinson's disease; BRCA cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.56 0.35 2.45e-20 Parkinson's disease; BRCA cis rs4481887 1.000 rs6666690 chr1:248465323 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.59 0.32 6.44e-17 Common traits (Other); BRCA cis rs7520050 0.966 rs4660898 chr1:46402171 A/G cg24296786 chr1:45957014 TESK2 0.44 9.87 0.36 1.74e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7523050 0.643 rs36047249 chr1:109401499 T/C cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg13010199 chr12:38710504 ALG10B 0.42 9.0 0.34 2.64e-18 Morning vs. evening chronotype; BRCA cis rs74417235 0.610 rs35212808 chr5:154057808 A/G cg08754654 chr5:154026448 NA 0.43 9.99 0.37 6.1e-22 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs17401966 0.931 rs12409754 chr1:10457540 T/C cg19773385 chr1:10388646 KIF1B -0.4 -8.53 -0.32 1.08e-16 Hepatocellular carcinoma; BRCA cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg12935359 chr14:103987150 CKB -0.59 -13.47 -0.47 1.42e-36 Intelligence (multi-trait analysis); BRCA cis rs690037 0.551 rs690522 chr3:16377067 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.39 -7.85 -0.3 1.75e-14 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); BRCA cis rs2463822 1.000 rs115395195 chr11:62100353 G/A cg06239285 chr11:62104954 ASRGL1 -0.66 -8.94 -0.33 4.29e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs6866344 0.697 rs11748497 chr5:178130012 C/G cg03877680 chr5:178157825 ZNF354A 0.79 14.73 0.5 1.74e-42 Neutrophil percentage of white cells; BRCA cis rs12926788 0.689 rs34365165 chr16:24856208 G/A cg04756594 chr16:24857601 SLC5A11 0.43 8.36 0.31 3.97e-16 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs58688157 0.705 rs7112149 chr11:595890 G/A cg16486109 chr11:613632 IRF7 0.42 8.81 0.33 1.17e-17 Systemic lupus erythematosus; BRCA trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg17470723 chr8:74884337 TCEB1 0.41 8.64 0.32 4.43e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs35146811 0.657 rs36019559 chr7:99814586 A/G cg13334819 chr7:99746414 C7orf59 0.34 8.01 0.3 5.56e-15 Coronary artery disease; BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg27170947 chr2:26402098 FAM59B -0.65 -11.27 -0.41 5.26e-27 Gut microbiome composition (summer); BRCA cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.42 0.32 2.42e-16 Bladder cancer; BRCA cis rs4613509 1 rs4613509 chr3:160728059 T/C cg03342759 chr3:160939853 NMD3 -0.46 -8.78 -0.33 1.53e-17 Morning vs. evening chronotype; BRCA cis rs7208859 0.673 rs9911989 chr17:29237702 A/C cg13385521 chr17:29058706 SUZ12P -0.61 -8.24 -0.31 1e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6121246 0.559 rs6060962 chr20:30397847 A/G cg21427119 chr20:30132790 HM13 -0.35 -7.95 -0.3 8.41e-15 Mean corpuscular hemoglobin; BRCA cis rs4285028 0.948 rs1920291 chr3:121672440 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs13136331 0.680 rs2732171 chr4:88655984 A/G cg12990093 chr4:88570587 DMP1 -0.4 -8.22 -0.31 1.14e-15 Sitting height ratio; BRCA cis rs9733 0.570 rs951281 chr1:150691122 A/C cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg14036092 chr11:66035641 RAB1B 0.39 10.23 0.38 7.55e-23 Gout; BRCA trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg15556689 chr8:8085844 FLJ10661 -0.32 -8.1 -0.31 2.85e-15 Triglycerides; BRCA cis rs2797160 0.837 rs1739364 chr6:126022383 A/G cg05901451 chr6:126070800 HEY2 -0.42 -10.07 -0.37 3.05e-22 Endometrial cancer; BRCA cis rs9341808 0.718 rs9352801 chr6:80817468 G/T cg08355045 chr6:80787529 NA 0.37 9.36 0.35 1.39e-19 Sitting height ratio; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg00106254 chr7:1943704 MAD1L1 -0.44 -10.94 -0.4 1.13e-25 Bipolar disorder and schizophrenia; BRCA trans rs1005277 0.522 rs7072977 chr10:37940440 C/A cg17830980 chr10:43048298 ZNF37B -0.42 -9.58 -0.35 2.18e-20 Extrinsic epigenetic age acceleration; BRCA cis rs6840360 0.571 rs11723395 chr4:152524191 G/A cg22705602 chr4:152727874 NA -0.33 -8.18 -0.31 1.54e-15 Intelligence (multi-trait analysis); BRCA cis rs10754283 0.934 rs10493829 chr1:90117833 T/C cg21401794 chr1:90099060 LRRC8C 0.48 11.9 0.43 1.29e-29 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.88 0.64 3.29e-74 Chronic sinus infection; BRCA cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg11366901 chr6:160182831 ACAT2 -0.65 -13.04 -0.46 1.24e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 6.53e-87 Chronic sinus infection; BRCA trans rs1994135 0.692 rs7297538 chr12:33693438 T/C cg26384229 chr12:38710491 ALG10B 0.59 11.89 0.43 1.4e-29 Resting heart rate; BRCA cis rs7819412 0.806 rs6980856 chr8:10938260 A/G cg21775007 chr8:11205619 TDH 0.45 9.01 0.34 2.37e-18 Triglycerides; BRCA cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg03452623 chr4:187889614 NA -0.32 -10.37 -0.38 2.09e-23 Lobe attachment (rater-scored or self-reported); BRCA trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg20587970 chr11:113659929 NA 1.02 14.49 0.5 2.42e-41 Hip circumference adjusted for BMI; BRCA cis rs11098499 0.954 rs59394118 chr4:120295551 A/G cg09307838 chr4:120376055 NA 0.73 15.95 0.53 1.9e-48 Corneal astigmatism; BRCA cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg24130564 chr14:104152367 KLC1 -0.41 -8.76 -0.33 1.75e-17 Reticulocyte count; BRCA cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg16006841 chr5:176797999 RGS14 -0.58 -11.6 -0.42 2.22e-28 Hemoglobin concentration;Hematocrit; BRCA cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.2 0.49 5.86e-40 Motion sickness; BRCA cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg26384229 chr12:38710491 ALG10B 0.65 14.16 0.49 8.57e-40 Morning vs. evening chronotype; BRCA cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg05283184 chr6:79620031 NA -0.43 -11.03 -0.4 4.97e-26 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg18479299 chr3:125709523 NA -0.54 -8.36 -0.31 4.05e-16 Blood pressure (smoking interaction); BRCA cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg07414643 chr4:187882934 NA 0.28 9.61 0.36 1.65e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs2806561 0.765 rs652706 chr1:23514246 G/A cg12483005 chr1:23474871 LUZP1 0.44 9.89 0.36 1.43e-21 Height; BRCA cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg02659138 chr7:134003124 SLC35B4 0.36 10.41 0.38 1.49e-23 Mean platelet volume; BRCA cis rs11711311 1.000 rs12497716 chr3:113453258 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.1 -0.37 2.47e-22 IgG glycosylation; BRCA cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -11.03 -0.4 4.91e-26 IgG glycosylation; BRCA cis rs2882667 0.690 rs10078079 chr5:138256139 C/T cg04439458 chr5:138467593 SIL1 -0.37 -8.9 -0.33 5.53e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4074536 0.574 rs10923362 chr1:116292908 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 5e-17 QRS duration; BRCA cis rs3809566 1.000 rs4774471 chr15:63332645 A/T cg05507819 chr15:63340323 TPM1 -0.41 -9.01 -0.34 2.38e-18 Platelet count; BRCA cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg00531865 chr16:30841666 NA -0.49 -11.35 -0.41 2.57e-27 Multiple myeloma; BRCA cis rs4363385 0.667 rs73014331 chr1:152964533 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.0 -0.34 2.53e-18 Inflammatory skin disease; BRCA cis rs713587 0.520 rs1530016 chr2:25305756 C/T cg01884057 chr2:25150051 NA -0.32 -8.32 -0.31 5.2e-16 Body mass index in non-asthmatics; BRCA cis rs4302748 0.862 rs11768269 chr7:36172741 A/G cg24442661 chr7:36192818 EEPD1 0.41 7.9 0.3 1.22e-14 Platelet count; BRCA cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg14530993 chr4:882597 GAK 0.51 8.69 0.33 2.99e-17 Parkinson's disease; BRCA cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg00701064 chr4:6280414 WFS1 0.71 18.93 0.6 8.74e-64 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs897080 0.515 rs1145519 chr2:44708709 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.14 0.34 8.3e-19 Height; BRCA cis rs7646881 0.812 rs73017540 chr3:158460788 T/A cg19483011 chr3:158453295 NA -0.46 -8.05 -0.3 4.08e-15 Tetralogy of Fallot; BRCA cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg02951883 chr7:2050386 MAD1L1 -0.52 -11.56 -0.42 3.45e-28 Bipolar disorder and schizophrenia; BRCA cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg15395560 chr15:45543142 SLC28A2 0.29 8.18 0.31 1.53e-15 Uric acid levels; BRCA cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.72 9.71 0.36 6.7e-21 Initial pursuit acceleration; BRCA cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg24562669 chr7:97807699 LMTK2 0.42 11.08 0.4 3.12e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs9790314 0.818 rs6797066 chr3:161008725 T/A cg03342759 chr3:160939853 NMD3 -0.72 -18.01 -0.58 5.81e-59 Morning vs. evening chronotype; BRCA cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg09455208 chr3:40491958 NA 0.53 11.94 0.43 8.23e-30 Renal cell carcinoma; BRCA cis rs599083 0.569 rs685095 chr11:68170376 C/T cg01657329 chr11:68192670 LRP5 0.37 8.31 0.31 5.83e-16 Bone mineral density (spine); BRCA cis rs17270561 0.943 rs4478398 chr6:25694684 T/C cg16482183 chr6:26056742 HIST1H1C 0.59 10.2 0.37 9.38e-23 Iron status biomarkers; BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg04944784 chr2:26401820 FAM59B -0.99 -16.67 -0.55 4.37e-52 Gut microbiome composition (summer); BRCA cis rs68170813 0.559 rs3823960 chr7:107009349 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.68 -0.32 3.23e-17 Coronary artery disease; BRCA cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg21427119 chr20:30132790 HM13 -0.42 -8.79 -0.33 1.38e-17 Mean corpuscular hemoglobin; BRCA cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.59 -12.11 -0.43 1.51e-30 Chronic sinus infection; BRCA cis rs600806 0.778 rs6693932 chr1:110003575 T/C cg20591472 chr1:110008990 SYPL2 0.31 7.89 0.3 1.31e-14 Intelligence (multi-trait analysis); BRCA cis rs709400 0.930 rs57447494 chr14:104034569 G/A cg12935359 chr14:103987150 CKB -0.46 -10.36 -0.38 2.25e-23 Body mass index; BRCA cis rs832540 0.519 rs10940518 chr5:56270794 C/T cg18230493 chr5:56204884 C5orf35 -0.41 -8.01 -0.3 5.54e-15 Coronary artery disease; BRCA cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg18876405 chr7:65276391 NA -0.62 -15.37 -0.52 1.36e-45 Aortic root size; BRCA cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg05283184 chr6:79620031 NA -0.37 -8.28 -0.31 7.09e-16 Intelligence (multi-trait analysis); BRCA cis rs10129255 0.556 rs8010005 chr14:107186226 A/G cg07958169 chr14:107095056 NA -0.4 -8.48 -0.32 1.59e-16 Kawasaki disease; BRCA cis rs7772486 0.875 rs2777481 chr6:146310036 G/T cg23711669 chr6:146136114 FBXO30 0.67 15.04 0.51 5.29e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7903847 0.642 rs11189200 chr10:99156273 C/G cg20016023 chr10:99160130 RRP12 -0.26 -8.53 -0.32 1.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg15112475 chr7:1198522 ZFAND2A -0.44 -8.6 -0.32 6.01e-17 Bronchopulmonary dysplasia; BRCA cis rs7640424 0.649 rs6795280 chr3:107876232 T/C cg09227934 chr3:107805635 CD47 -0.37 -7.86 -0.3 1.62e-14 Body mass index; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg09177884 chr7:1199841 ZFAND2A -0.58 -13.0 -0.46 1.84e-34 Longevity;Endometriosis; BRCA cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26314531 chr2:26401878 FAM59B 0.6 10.04 0.37 3.98e-22 Gut microbiome composition (summer); BRCA cis rs10927875 0.541 rs1048237 chr1:16341733 T/C cg06159980 chr1:16340746 HSPB7 -0.38 -8.84 -0.33 9.14e-18 Dilated cardiomyopathy; BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.14 -0.46 4.59e-35 Lymphocyte counts; BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.53 10.52 0.38 5.52e-24 Lymphocyte counts; BRCA cis rs7572733 0.534 rs771009 chr2:198691082 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.17 0.37 1.3e-22 Dermatomyositis; BRCA cis rs113835537 0.529 rs17580784 chr11:66214859 T/A cg24851651 chr11:66362959 CCS 0.5 8.75 0.33 1.94e-17 Airway imaging phenotypes; BRCA cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg13010199 chr12:38710504 ALG10B 0.43 9.14 0.34 7.95e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs754466 0.830 rs61854186 chr10:79703255 G/A cg17075019 chr10:79541650 NA -0.63 -11.83 -0.42 2.52e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg08999081 chr20:33150536 PIGU -0.44 -12.38 -0.44 1.01e-31 Glomerular filtration rate (creatinine); BRCA cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg06028605 chr16:24865363 SLC5A11 0.43 9.53 0.35 3.1e-20 Intelligence (multi-trait analysis); BRCA cis rs6782228 0.606 rs2811497 chr3:128363332 C/T cg16766828 chr3:128327626 NA -0.43 -9.64 -0.36 1.22e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs17270561 0.609 rs9358883 chr6:25755515 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.7 0.33 2.82e-17 Iron status biomarkers; BRCA cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.8 -0.33 1.25e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.52 0.32 1.12e-16 Electroencephalogram traits; BRCA cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg23788917 chr6:8435910 SLC35B3 0.47 10.27 0.38 5.4e-23 Motion sickness; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg04166393 chr7:2884313 GNA12 0.5 9.59 0.35 1.96e-20 Height; BRCA trans rs7829975 0.623 rs10087493 chr8:8373557 A/G cg16141378 chr3:129829833 LOC729375 0.34 8.3 0.31 6.28e-16 Mood instability; BRCA cis rs67981189 0.679 rs221901 chr14:71602226 C/T cg15816911 chr14:71606274 NA -0.38 -8.27 -0.31 7.72e-16 Schizophrenia; BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.25 -0.31 9.29e-16 Gut microbiome composition (summer); BRCA cis rs7264396 0.563 rs2425114 chr20:34322346 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg02376097 chr19:46275166 DMPK 0.47 10.57 0.39 3.64e-24 Coronary artery disease; BRCA cis rs7523050 0.730 rs12079547 chr1:109469314 A/C cg08274380 chr1:109419600 GPSM2 0.98 14.31 0.49 1.79e-40 Fat distribution (HIV); BRCA cis rs911119 1.000 rs6114206 chr20:23611789 A/G cg16589663 chr20:23618590 CST3 0.46 8.68 0.32 3.24e-17 Chronic kidney disease; BRCA cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg22676075 chr6:135203613 NA 0.45 8.79 0.33 1.38e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs61931739 0.534 rs6488189 chr12:33995865 C/T cg06521331 chr12:34319734 NA -0.62 -11.18 -0.4 1.28e-26 Morning vs. evening chronotype; BRCA cis rs6893300 0.857 rs6860716 chr5:179162840 T/C cg14593053 chr5:179126677 CANX -0.36 -8.06 -0.3 3.85e-15 Resting heart rate; BRCA cis rs9341808 0.558 rs2322635 chr6:80897210 A/G cg08355045 chr6:80787529 NA 0.32 7.81 0.3 2.37e-14 Sitting height ratio; BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg11062466 chr8:58055876 NA 0.49 8.67 0.32 3.64e-17 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11890956 chr21:40555474 PSMG1 1.04 28.18 0.74 3.6e-114 Cognitive function; BRCA cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg06238570 chr21:40685208 BRWD1 -0.39 -8.09 -0.3 3.07e-15 Menarche (age at onset); BRCA cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg08885076 chr2:99613938 TSGA10 -0.5 -9.22 -0.34 4.36e-19 Chronic sinus infection; BRCA cis rs6840360 0.593 rs6847844 chr4:152693246 C/T cg22705602 chr4:152727874 NA -0.38 -10.58 -0.39 3.14e-24 Intelligence (multi-trait analysis); BRCA cis rs57221529 0.545 rs55955015 chr5:575182 A/G cg09021430 chr5:549028 NA -0.68 -14.28 -0.49 2.5e-40 Lung disease severity in cystic fibrosis; BRCA cis rs2013441 1.000 rs2107566 chr17:20103252 C/T cg13482628 chr17:19912719 NA -0.4 -8.9 -0.33 5.77e-18 Obesity-related traits; BRCA cis rs941873 0.805 rs8837 chr10:81114813 C/G cg11057378 chr10:81107060 PPIF 0.39 8.95 0.33 3.96e-18 Height; BRCA cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg01483505 chr11:975446 AP2A2 0.34 9.14 0.34 7.89e-19 Alzheimer's disease (late onset); BRCA cis rs10267417 0.603 rs6960607 chr7:19869407 A/G cg07541023 chr7:19748670 TWISTNB 0.47 8.49 0.32 1.49e-16 Night sleep phenotypes; BRCA cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg16325326 chr1:53192061 ZYG11B -0.66 -16.28 -0.54 4.2e-50 Monocyte count; BRCA cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg23583168 chr7:148888333 NA -0.85 -19.85 -0.62 1.13e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs853679 0.607 rs28360499 chr6:27945396 G/A cg06606381 chr12:133084897 FBRSL1 -0.89 -8.78 -0.33 1.44e-17 Depression; BRCA cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg08085267 chr17:45401833 C17orf57 -0.64 -13.75 -0.48 7.49e-38 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg24112000 chr20:60950667 NA 0.49 9.48 0.35 4.82e-20 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg12463550 chr7:65579703 CRCP -0.37 -8.1 -0.31 2.84e-15 Aortic root size; BRCA cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg08885076 chr2:99613938 TSGA10 0.41 9.62 0.36 1.45e-20 Chronic sinus infection; BRCA cis rs425277 1.000 rs421992 chr1:2077260 C/T cg24578937 chr1:2090814 PRKCZ 0.58 17.89 0.58 2.47e-58 Height; BRCA cis rs1580019 0.961 rs1580022 chr7:32497712 C/A cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.29 0.54 3.92e-50 Cognitive ability; BRCA trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg03929089 chr4:120376271 NA 0.57 9.27 0.34 2.8e-19 Axial length; BRCA cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg19901468 chr14:105411992 AHNAK2 -0.51 -12.43 -0.44 6.12e-32 Rheumatoid arthritis; BRCA cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.56 -9.87 -0.36 1.78e-21 Body mass index (adult); BRCA cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg18850127 chr7:39170497 POU6F2 0.5 10.96 0.4 1.02e-25 IgG glycosylation; BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg08280861 chr8:58055591 NA 0.53 8.4 0.32 2.84e-16 Developmental language disorder (linguistic errors); BRCA trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg25206134 chr2:45395956 NA 0.51 8.68 0.32 3.31e-17 Bipolar disorder; BRCA cis rs739401 0.572 rs410820 chr11:3080102 G/A cg08508325 chr11:3079039 CARS -0.45 -16.17 -0.54 1.41e-49 Longevity; BRCA cis rs9457247 0.638 rs239933 chr6:167413230 A/G cg07741184 chr6:167504864 NA 0.28 7.99 0.3 6.14e-15 Crohn's disease; BRCA cis rs1401999 1.000 rs4148579 chr3:183685249 T/C cg20387954 chr3:183756860 HTR3D 0.45 10.02 0.37 4.7e-22 Anterior chamber depth; BRCA cis rs460214 0.576 rs2836604 chr21:40041295 A/C cg21578987 chr21:40029669 ERG 0.34 8.21 0.31 1.2e-15 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs6842047 1.000 rs9995366 chr4:187131384 T/C cg23442198 chr4:187126114 CYP4V2 0.66 8.98 0.33 3.13e-18 Blood protein levels; BRCA cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg14844989 chr11:31128820 NA 0.47 9.96 0.37 7.98e-22 Bone mineral density (spine); BRCA cis rs4803468 0.967 rs4803462 chr19:41908936 T/A cg09537434 chr19:41945824 ATP5SL -0.99 -23.45 -0.68 3.09e-88 Height; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg03354898 chr7:1950403 MAD1L1 -0.49 -10.09 -0.37 2.57e-22 Bipolar disorder and schizophrenia; BRCA cis rs28595532 0.546 rs36058627 chr4:119233201 G/T cg21605333 chr4:119757512 SEC24D 0.83 8.78 0.33 1.46e-17 Cannabis dependence symptom count; BRCA cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg17366294 chr4:99064904 C4orf37 0.44 10.31 0.38 3.67e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs9291683 0.588 rs3733586 chr4:9997534 C/T cg26043149 chr18:55253948 FECH 0.4 8.8 0.33 1.24e-17 Bone mineral density; BRCA cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg24596788 chr1:163392923 NA 0.42 11.12 0.4 2.27e-26 Motion sickness; BRCA trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.51 -0.32 1.22e-16 Total body bone mineral density; BRCA cis rs965469 0.779 rs6515791 chr20:3310443 C/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.87 -0.33 7.39e-18 IFN-related cytopenia; BRCA cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 8.14 0.31 2.03e-15 Personality dimensions; BRCA trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg15704280 chr7:45808275 SEPT13 0.64 11.28 0.41 4.86e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg01877450 chr7:97915802 BRI3 -0.37 -8.36 -0.31 3.93e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs58235267 0.543 rs2539990 chr2:63170185 C/T cg17519650 chr2:63277830 OTX1 0.43 10.01 0.37 5.36e-22 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg00814883 chr7:100076585 TSC22D4 -0.48 -10.01 -0.37 5.03e-22 Platelet count; BRCA cis rs7246967 0.673 rs4933036 chr19:22963069 C/A cg23217946 chr19:22817039 ZNF492 0.5 9.11 0.34 1.04e-18 Bronchopulmonary dysplasia; BRCA cis rs2624839 0.704 rs2624833 chr3:50212512 G/T cg14019146 chr3:50243930 SLC38A3 -0.65 -15.89 -0.53 3.57e-48 Intelligence (multi-trait analysis); BRCA cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg04756594 chr16:24857601 SLC5A11 -0.34 -8.89 -0.33 6.34e-18 Intelligence (multi-trait analysis); BRCA trans rs9858542 0.953 rs9878943 chr3:49434654 G/A cg21659725 chr3:3221576 CRBN -0.45 -9.87 -0.36 1.73e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg20476274 chr7:133979776 SLC35B4 0.51 11.82 0.42 2.71e-29 Mean platelet volume; BRCA cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.05 -0.4 4.1e-26 Extrinsic epigenetic age acceleration; BRCA cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg11266682 chr4:10021025 SLC2A9 0.49 13.16 0.46 3.67e-35 Bone mineral density; BRCA cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg24692254 chr21:30365293 RNF160 0.66 18.19 0.58 6.62e-60 Dental caries; BRCA trans rs6952808 0.689 rs4719391 chr7:2048136 T/C cg04565464 chr8:145669602 NFKBIL2 0.34 8.17 0.31 1.59e-15 Bipolar disorder and schizophrenia; BRCA cis rs877529 0.967 rs12158877 chr22:39549426 T/G cg18708252 chr22:39545030 CBX7 -0.31 -8.14 -0.31 2.02e-15 Multiple myeloma; BRCA cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg23109721 chr2:106886537 NA 0.55 10.83 0.39 3.36e-25 Facial morphology (factor 23); BRCA cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.86 -0.33 7.99e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg11584989 chr19:19387371 SF4 -0.65 -14.21 -0.49 4.81e-40 Bipolar disorder; BRCA cis rs350251 0.899 rs350275 chr16:12233099 G/C cg06014057 chr16:12226852 SNX29 0.29 7.91 0.3 1.15e-14 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg10932868 chr11:921992 NA -0.5 -12.77 -0.45 2.09e-33 Alzheimer's disease (late onset); BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 21.81 0.65 2.95e-79 Platelet count; BRCA cis rs9859260 0.710 rs419068 chr3:195782176 C/T cg12923728 chr3:195709715 SDHAP1 0.38 7.85 0.3 1.72e-14 Mean corpuscular volume; BRCA cis rs908922 0.676 rs539393 chr1:152518896 C/T cg20991723 chr1:152506922 NA 0.37 8.32 0.31 5.36e-16 Hair morphology; BRCA trans rs8002861 0.967 rs7994883 chr13:44478805 A/G cg17145862 chr1:211918768 LPGAT1 -0.68 -17.82 -0.58 5.77e-58 Leprosy; BRCA cis rs875971 0.660 rs801192 chr7:66031952 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.38 -0.31 3.25e-16 Aortic root size; BRCA cis rs9815354 1.000 rs9815354 chr3:41912651 G/A cg03022575 chr3:42003672 ULK4 0.51 8.31 0.31 5.54e-16 Pulse pressure;Diastolic blood pressure; BRCA cis rs7267979 1.000 rs2482940 chr20:25349830 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9942416 0.660 rs193344 chr5:74977854 T/C cg19683494 chr5:74908142 NA -0.44 -8.66 -0.32 3.74e-17 Age-related disease endophenotypes; BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 21.92 0.66 7.54e-80 Platelet count; BRCA cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11644478 chr21:40555479 PSMG1 0.88 20.84 0.64 5.49e-74 Cognitive function; BRCA cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg26384229 chr12:38710491 ALG10B 0.69 16.13 0.54 2.41e-49 Bladder cancer; BRCA trans rs6964833 0.872 rs4717903 chr7:74068167 T/C cg07504079 chr7:72649617 NCF1B -0.47 -9.19 -0.34 5.46e-19 Menarche (age at onset); BRCA cis rs72781680 0.716 rs72788206 chr2:24084989 T/C cg08917208 chr2:24149416 ATAD2B 0.61 10.24 0.38 7.17e-23 Lymphocyte counts; BRCA cis rs6542838 0.611 rs1976766 chr2:99522754 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.24 -0.34 3.52e-19 Fear of minor pain; BRCA cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.36 -13.3 -0.47 8.04e-36 Autism spectrum disorder or schizophrenia; BRCA cis rs2130392 0.926 rs7677893 chr4:185625523 T/C cg04058563 chr4:185651563 MLF1IP 0.36 9.0 0.34 2.47e-18 Kawasaki disease; BRCA cis rs4808199 0.894 rs10418051 chr19:19397789 C/T cg01262667 chr19:19385393 TM6SF2 0.39 8.3 0.31 6.37e-16 Nonalcoholic fatty liver disease; BRCA cis rs7246657 0.943 rs8106839 chr19:37958475 C/G cg23950597 chr19:37808831 NA -0.67 -12.13 -0.43 1.28e-30 Coronary artery calcification; BRCA cis rs9486719 1.000 rs6921291 chr6:97066242 C/T cg06623918 chr6:96969491 KIAA0776 -0.79 -13.84 -0.48 2.81e-38 Migraine;Coronary artery disease; BRCA cis rs7766436 0.848 rs13211568 chr6:22573180 A/T cg13666174 chr6:22585274 NA -0.45 -9.64 -0.36 1.21e-20 Coronary artery disease; BRCA cis rs2279817 0.863 rs2354291 chr1:18027554 G/T cg21791023 chr1:18019539 ARHGEF10L -0.47 -14.34 -0.49 1.21e-40 Neuroticism; BRCA cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10463316 0.747 rs10077700 chr5:150768324 A/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.33 -0.31 4.92e-16 Metabolite levels (Pyroglutamine); BRCA trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.31 8.55 0.32 8.8e-17 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg08564027 chr20:61660810 NA 0.69 14.23 0.49 4.26e-40 Prostate cancer (SNP x SNP interaction); BRCA cis rs2742234 0.590 rs2435338 chr10:43642115 A/G cg15436174 chr10:43711423 RASGEF1A -0.54 -10.96 -0.4 1.02e-25 Hirschsprung disease; BRCA cis rs853679 0.517 rs9393884 chr6:28046789 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.23 -0.31 1.06e-15 Depression; BRCA cis rs9818758 0.607 rs9847839 chr3:49289003 T/C cg00383909 chr3:49044727 WDR6 0.71 12.7 0.45 4.18e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs13102973 0.932 rs4130840 chr4:135869598 T/G cg14419869 chr4:135874104 NA -0.59 -13.06 -0.46 1.02e-34 Subjective well-being; BRCA cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg16145915 chr7:1198662 ZFAND2A -0.41 -7.87 -0.3 1.48e-14 Bronchopulmonary dysplasia; BRCA cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg17143192 chr8:8559678 CLDN23 0.57 11.1 0.4 2.61e-26 Obesity-related traits; BRCA cis rs4363385 0.720 rs1984197 chr1:152962915 C/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.3 -0.35 2.13e-19 Inflammatory skin disease; BRCA cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg10523679 chr1:76189770 ACADM -0.47 -9.1 -0.34 1.17e-18 Daytime sleep phenotypes; BRCA cis rs6120849 0.754 rs6120788 chr20:33583716 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.35 0.38 2.61e-23 Protein C levels; BRCA trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.5 -0.32 1.32e-16 Extrinsic epigenetic age acceleration; BRCA cis rs586533 0.881 rs674717 chr11:99506867 A/T cg22878054 chr11:99397252 CNTN5 0.32 8.24 0.31 9.43e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.17 -0.31 1.66e-15 Aortic root size; BRCA cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg05890377 chr2:74357713 NA 0.5 12.27 0.44 3.24e-31 Gestational age at birth (maternal effect); BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg22907277 chr7:1156413 C7orf50 0.6 11.44 0.41 1.04e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg24531977 chr5:56204891 C5orf35 -0.87 -17.9 -0.58 2.27e-58 Initial pursuit acceleration; BRCA cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg12641515 chr19:46296257 DMWD 0.71 17.75 0.57 1.37e-57 Coronary artery disease; BRCA cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02018176 chr4:1364513 KIAA1530 0.4 8.21 0.31 1.2e-15 Longevity; BRCA cis rs6772849 0.930 rs55987729 chr3:128340110 T/C cg16766828 chr3:128327626 NA -0.38 -8.48 -0.32 1.57e-16 Monocyte percentage of white cells;Monocyte count; BRCA cis rs4363385 0.818 rs441229 chr1:153015059 A/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.46 -0.32 1.88e-16 Inflammatory skin disease; BRCA cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg04727924 chr7:799746 HEATR2 -0.57 -11.27 -0.41 5.25e-27 Cerebrospinal P-tau181p levels; BRCA cis rs7085104 0.572 rs284858 chr10:104573936 T/C cg04362960 chr10:104952993 NT5C2 -0.33 -7.97 -0.3 7.18e-15 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg18876405 chr7:65276391 NA -0.5 -11.01 -0.4 6.44e-26 Aortic root size; BRCA cis rs7523273 0.526 rs2724375 chr1:207997973 C/A cg22525895 chr1:207977042 MIR29B2 -0.5 -12.75 -0.45 2.59e-33 Schizophrenia; BRCA cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 2.02e-19 Schizophrenia; BRCA cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg18904891 chr8:8559673 CLDN23 -0.52 -9.63 -0.36 1.38e-20 Obesity-related traits; BRCA cis rs829883 0.724 rs3168521 chr12:98908547 C/T cg25150519 chr12:98850993 NA -0.51 -9.34 -0.35 1.54e-19 Colorectal adenoma (advanced); BRCA cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.5 0.5 2.04e-41 Colorectal cancer; BRCA cis rs478304 0.654 rs12289836 chr11:65436888 C/T cg10518572 chr11:65560635 OVOL1 0.28 8.15 0.31 1.99e-15 Acne (severe); BRCA cis rs965469 1.000 rs6051718 chr20:3270370 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.51 -0.38 6.02e-24 IFN-related cytopenia; BRCA cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3768617 0.811 rs12043805 chr1:183008150 T/A ch.1.3577855R chr1:183094577 LAMC1 0.45 9.89 0.36 1.46e-21 Fuchs's corneal dystrophy; BRCA cis rs7072216 0.763 rs942804 chr10:100168499 C/A cg26618903 chr10:100175079 PYROXD2 -0.31 -8.87 -0.33 7.47e-18 Metabolite levels; BRCA cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg06671706 chr8:8559999 CLDN23 0.43 8.31 0.31 5.84e-16 Obesity-related traits; BRCA cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg07148914 chr20:33460835 GGT7 0.38 8.63 0.32 4.77e-17 Height; BRCA cis rs11719291 0.667 rs9877542 chr3:48748545 C/T cg07636037 chr3:49044803 WDR6 -0.58 -8.37 -0.31 3.57e-16 Cognitive function; BRCA cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.61 -12.14 -0.43 1.13e-30 Tonsillectomy; BRCA cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg01028140 chr2:1542097 TPO -0.62 -12.85 -0.45 8.52e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg12317470 chr15:67143691 NA 0.47 8.21 0.31 1.26e-15 Lung cancer (smoking interaction); BRCA cis rs9296092 0.538 rs9469486 chr6:33516849 G/A cg13560919 chr6:33536144 NA -0.85 -18.39 -0.59 6.37e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg02476566 chr12:106696527 TCP11L2 0.51 9.48 0.35 4.7e-20 Tourette syndrome; BRCA cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg06026331 chr20:60912101 LAMA5 -0.48 -10.02 -0.37 4.8e-22 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg11279151 chr3:101281821 RG9MTD1 -0.34 -7.85 -0.3 1.76e-14 Colorectal cancer; BRCA cis rs208520 0.507 rs7755710 chr6:66783355 G/A cg07460842 chr6:66804631 NA -1.17 -37.04 -0.83 3.07e-161 Exhaled nitric oxide output; BRCA cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg24558204 chr6:135376177 HBS1L 0.52 11.52 0.41 4.92e-28 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7647973 0.626 rs62262722 chr3:49769419 G/C cg03060546 chr3:49711283 APEH -0.59 -8.48 -0.32 1.55e-16 Menarche (age at onset); BRCA cis rs7147624 1.000 rs1009465 chr14:65970370 G/C cg03016385 chr14:66212404 NA -0.55 -8.3 -0.31 6.42e-16 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs9807989 0.507 rs6749014 chr2:103006448 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.42 0.32 2.39e-16 Asthma; BRCA cis rs1801251 1.000 rs283474 chr2:233654627 A/G cg08000102 chr2:233561755 GIGYF2 0.61 13.0 0.46 1.96e-34 Coronary artery disease; BRCA cis rs425277 0.538 rs169037 chr1:2095582 G/T cg19257562 chr1:2043853 PRKCZ -0.35 -9.77 -0.36 4.21e-21 Height; BRCA cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg18132916 chr6:79620363 NA -0.49 -11.16 -0.4 1.53e-26 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7818345 1.000 rs6981898 chr8:19305705 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 8.46 0.32 1.84e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.659 rs59668095 chr9:5043688 C/G cg02405213 chr9:5042618 JAK2 -0.51 -9.12 -0.34 9.89e-19 Pediatric autoimmune diseases; BRCA cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg00631329 chr6:26305371 NA -0.48 -13.62 -0.47 2.93e-37 Educational attainment; BRCA cis rs2481665 0.772 rs6668600 chr1:62536683 C/G cg18591186 chr1:62594603 INADL 0.54 12.42 0.44 7.37e-32 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9287719 0.967 rs6432117 chr2:10749359 G/C cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.66 12.38 0.44 1.06e-31 Alzheimer's disease; BRCA trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg13010199 chr12:38710504 ALG10B 0.49 9.56 0.35 2.42e-20 Morning vs. evening chronotype; BRCA cis rs4780401 0.703 rs3190321 chr16:11773662 C/G cg01061890 chr16:11836724 TXNDC11 -0.42 -9.26 -0.34 3.1400000000000002e-19 Rheumatoid arthritis; BRCA trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg11707556 chr5:10655725 ANKRD33B -0.44 -9.73 -0.36 6e-21 Coronary artery disease; BRCA cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg24397884 chr7:158709396 WDR60 0.63 13.19 0.46 2.63e-35 Height; BRCA cis rs13064411 0.591 rs7628945 chr3:113201754 A/T cg18753928 chr3:113234510 CCDC52 -0.46 -9.92 -0.37 1.14e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg23505145 chr19:12996616 KLF1 0.54 12.28 0.44 2.95e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.566 rs7249692 chr19:19670688 T/C cg03709012 chr19:19516395 GATAD2A -0.5 -9.95 -0.37 8.69e-22 Tonsillectomy; BRCA trans rs208520 0.661 rs207099 chr6:66796373 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.04 -0.64 4.67e-75 Exhaled nitric oxide output; BRCA cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.84 0.33 9.42e-18 Motion sickness; BRCA cis rs3743832 0.520 rs8045589 chr16:9210373 A/T cg08831531 chr16:9218945 NA 0.38 7.99 0.3 6.21e-15 Non-substance related behavioral disinhibition;Behavioural disinhibition (generation interaction); BRCA cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg22307029 chr19:49891270 CCDC155 0.54 9.03 0.34 2.04e-18 Multiple sclerosis; BRCA cis rs7246657 0.943 rs10404602 chr19:37825633 A/T cg23950597 chr19:37808831 NA -0.72 -12.54 -0.44 2.15e-32 Coronary artery calcification; BRCA cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg02574844 chr11:5959923 NA -0.42 -8.16 -0.31 1.79e-15 DNA methylation (variation); BRCA cis rs7651736 0.835 rs6439679 chr3:136757463 C/T cg21827317 chr3:136751795 NA -0.48 -10.49 -0.38 7.05e-24 Neuroticism; BRCA cis rs2859741 0.967 rs534131 chr1:37484237 T/C cg09363841 chr1:37513479 NA -0.66 -16.63 -0.55 7.46e-52 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs6669384 0.547 rs2745979 chr1:208018219 G/C cg22525895 chr1:207977042 MIR29B2 -0.41 -9.11 -0.34 1.08e-18 Immune response to measles vaccine (measles-specific neutralising antibody titre); BRCA cis rs11098499 0.954 rs11734241 chr4:120416872 A/G cg09307838 chr4:120376055 NA 0.72 15.24 0.52 5.6e-45 Corneal astigmatism; BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 21.62 0.65 3.42e-78 Platelet count; BRCA cis rs754466 0.580 rs12356063 chr10:79558131 G/C cg17075019 chr10:79541650 NA -0.87 -23.79 -0.69 4.63e-90 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.43 -0.32 2.26e-16 Monocyte percentage of white cells; BRCA cis rs7258465 1.000 rs10405636 chr19:18538742 A/C cg01065977 chr19:18549689 ISYNA1 -0.29 -8.76 -0.33 1.81e-17 Breast cancer; BRCA cis rs4742903 0.967 rs2417485 chr9:106867106 A/C cg14250997 chr9:106856677 SMC2 0.35 11.18 0.4 1.21e-26 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7927771 1.000 rs12419692 chr11:47624714 A/C cg18512352 chr11:47633146 NA 0.35 8.68 0.32 3.31e-17 Subjective well-being; BRCA cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg12386194 chr3:101231763 SENP7 0.67 13.0 0.46 1.96e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg27446573 chr6:127587934 RNF146 0.84 18.9 0.6 1.34e-63 Breast cancer; BRCA cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7100689 0.556 rs10788541 chr10:82016530 T/G cg01528321 chr10:82214614 TSPAN14 0.71 15.83 0.53 7.55e-48 Post bronchodilator FEV1; BRCA cis rs2415984 0.644 rs1669808 chr14:46930473 A/G cg14871534 chr14:47121158 RPL10L 0.33 8.06 0.3 3.77e-15 Number of children ever born; BRCA cis rs12618769 0.597 rs72819996 chr2:99059983 G/A cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs698833 0.788 rs1142523 chr2:44545576 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.65 0.39 1.78e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg18132916 chr6:79620363 NA -0.5 -11.27 -0.41 5.13e-27 Intelligence (multi-trait analysis); BRCA cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.53 16.56 0.55 1.64e-51 Intelligence (multi-trait analysis); BRCA cis rs8038465 0.615 rs4075802 chr15:73963239 A/G cg15420318 chr15:73925796 NPTN 0.41 9.12 0.34 9.27e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg06115741 chr20:33292138 TP53INP2 -0.38 -8.45 -0.32 1.97e-16 Glomerular filtration rate (creatinine); BRCA cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg18918831 chr3:195489782 MUC4 0.56 9.0 0.34 2.56e-18 Lung disease severity in cystic fibrosis; BRCA cis rs6558530 0.932 rs6558531 chr8:1707566 A/G cg19131313 chr8:1704013 NA -0.37 -7.85 -0.3 1.77e-14 Systolic blood pressure; BRCA cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg22875332 chr1:76189707 ACADM 0.62 11.91 0.43 1.17e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11608355 0.545 rs35018715 chr12:109893134 T/C cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs1829883 1.000 rs2461991 chr5:98793332 C/G cg08333243 chr5:99726346 NA -0.36 -8.81 -0.33 1.22e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs2635047 1.000 rs9304341 chr18:44670263 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 8.89 0.33 5.97e-18 Educational attainment; BRCA cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 8.99 0.34 2.74e-18 Response to antipsychotic treatment; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.7 -11.88 -0.43 1.57e-29 Platelet count; BRCA cis rs35661897 0.920 rs62190909 chr2:227294858 C/G cg03426602 chr2:227312417 NA -0.52 -8.87 -0.33 7.55e-18 Urinary tract infection frequency; BRCA cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs312274 0.507 rs3816251 chr12:41318169 G/T cg17827154 chr12:41323612 CNTN1 -0.43 -10.63 -0.39 2.05e-24 Metabolite levels (X-11787); BRCA cis rs2370759 1.000 rs78959390 chr10:32616346 C/T cg01819863 chr10:32635814 EPC1 1.17 20.75 0.63 1.69e-73 Sexual dysfunction (female); BRCA cis rs2243480 1.000 rs35825738 chr7:65318027 A/G cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs8044868 0.530 rs8059437 chr16:72116467 A/G cg16558253 chr16:72132732 DHX38 -0.48 -11.28 -0.41 5.08e-27 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs10129255 0.518 rs11847766 chr14:107187425 T/C cg07958169 chr14:107095056 NA -0.39 -8.54 -0.32 9.72e-17 Kawasaki disease; BRCA cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.93e-24 Motion sickness; BRCA cis rs9325144 1.000 rs7963123 chr12:38976617 C/T cg26384229 chr12:38710491 ALG10B -0.45 -9.46 -0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -7.83 -0.3 2.1e-14 Total body bone mineral density; BRCA cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 9.02 0.34 2.2e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11051970 0.704 rs2733694 chr12:32555230 A/G cg24626660 chr12:32551988 NA 0.32 9.43 0.35 7.74e-20 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs754466 0.580 rs10824573 chr10:79540969 T/C cg17075019 chr10:79541650 NA -0.84 -20.61 -0.63 9.89e-73 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs6076960 0.846 rs6053962 chr20:6176915 A/G cg21095983 chr6:86352623 SYNCRIP 0.41 9.7 0.36 7.65e-21 Smooth-surface caries; BRCA cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11890956 chr21:40555474 PSMG1 0.82 20.69 0.63 3.72e-73 Cognitive function; BRCA cis rs12971120 1.000 rs734559 chr18:72179579 G/A cg25817165 chr18:72167213 CNDP2 -0.74 -14.1 -0.49 1.58e-39 Refractive error; BRCA cis rs2116941 1.000 rs7250265 chr19:10339818 G/C cg01850179 chr19:10340795 S1PR2 -0.64 -12.58 -0.45 1.41e-32 Pulse pressure; BRCA trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.05 -0.56 5.13e-54 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.32 0.66 4.72e-82 Chronic sinus infection; BRCA cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg10523679 chr1:76189770 ACADM 0.62 10.61 0.39 2.49e-24 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg24549020 chr5:56110836 MAP3K1 0.58 11.73 0.42 6.76e-29 Initial pursuit acceleration; BRCA cis rs9527 0.615 rs11191489 chr10:104740568 C/A cg04362960 chr10:104952993 NT5C2 0.47 10.8 0.39 4.18e-25 Arsenic metabolism; BRCA cis rs7258465 0.965 rs7253990 chr19:18604085 C/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.26 -0.31 8.25e-16 Breast cancer; BRCA cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg13902645 chr11:5959945 NA -0.48 -10.42 -0.38 1.34e-23 DNA methylation (variation); BRCA cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.02 15.09 0.51 3.01e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA cis rs10197940 0.550 rs77233070 chr2:152416477 G/A cg06191203 chr2:152266755 RIF1 -0.34 -9.28 -0.34 2.67e-19 Lung cancer; BRCA cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA trans rs783540 0.967 rs17158390 chr15:83293028 A/G cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.61 -0.32 5.71e-17 Schizophrenia; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.17 -0.34 6.4e-19 Total body bone mineral density; BRCA cis rs16976116 0.901 rs28433503 chr15:55499857 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg12863693 chr15:85201151 NMB 0.45 8.22 0.31 1.16e-15 Schizophrenia; BRCA cis rs11955398 0.585 rs12655977 chr5:60034475 A/G cg02684056 chr5:59996105 DEPDC1B 0.38 8.99 0.34 2.82e-18 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg11266682 chr4:10021025 SLC2A9 0.45 11.99 0.43 4.9e-30 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10045504 0.502 rs72746038 chr5:38753999 G/A cg15396434 chr5:38725168 NA -0.56 -10.55 -0.39 4.41e-24 Night sleep phenotypes; BRCA cis rs2839186 0.843 rs17182671 chr21:47696238 T/C cg12379764 chr21:47803548 PCNT -0.38 -8.24 -0.31 9.57e-16 Testicular germ cell tumor; BRCA cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg09555818 chr19:45449301 APOC2 0.48 12.7 0.45 4.25e-33 Blood protein levels; BRCA trans rs11039798 0.844 rs41431447 chr11:48983199 A/G cg15704280 chr7:45808275 SEPT13 0.66 7.89 0.3 1.27e-14 Axial length; BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg22907277 chr7:1156413 C7orf50 0.65 12.23 0.44 4.83e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1401999 1.000 rs6804242 chr3:183659463 A/T cg01324343 chr3:183735012 ABCC5 0.83 20.91 0.64 2.19e-74 Anterior chamber depth; BRCA cis rs4363385 0.693 rs76987906 chr1:152964530 A/G cg21543102 chr1:152974771 SPRR3 -0.31 -8.92 -0.33 4.88e-18 Inflammatory skin disease; BRCA cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.5 -10.07 -0.37 3.07e-22 Tonsillectomy; BRCA trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg15704280 chr7:45808275 SEPT13 -0.72 -15.88 -0.53 3.95e-48 Coronary artery disease; BRCA cis rs17401966 0.838 rs10492971 chr1:10342975 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.78 0.48 5.32e-38 Hepatocellular carcinoma; BRCA cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg06064525 chr11:970664 AP2A2 -0.49 -16.45 -0.55 5.71e-51 Alzheimer's disease (late onset); BRCA cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg23711669 chr6:146136114 FBXO30 0.72 16.38 0.54 1.28e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.966 rs2227892 chr20:25264814 T/C cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg17211192 chr8:82754475 SNX16 -0.62 -11.53 -0.42 4.32e-28 Diastolic blood pressure; BRCA cis rs7246657 0.943 rs10413602 chr19:37891492 T/C cg18154014 chr19:37997991 ZNF793 0.62 11.63 0.42 1.7e-28 Coronary artery calcification; BRCA cis rs11190604 1.000 rs9419897 chr10:102246125 T/C cg07080220 chr10:102295463 HIF1AN 0.51 11.48 0.41 7.13e-28 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs910316 1.000 rs175443 chr14:75601963 C/T cg23033748 chr14:75592666 NEK9 -0.43 -10.49 -0.38 7.42e-24 Height; BRCA cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg11843238 chr5:131593191 PDLIM4 0.36 7.88 0.3 1.39e-14 Breast cancer; BRCA cis rs61931739 0.500 rs73103774 chr12:34482279 C/T cg06521331 chr12:34319734 NA -0.56 -10.19 -0.37 1.08e-22 Morning vs. evening chronotype; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg14863265 chr7:2801509 GNA12 -0.4 -9.27 -0.34 2.81e-19 Height; BRCA cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg11764359 chr7:65958608 NA -0.76 -16.98 -0.56 1.25e-53 Aortic root size; BRCA cis rs826838 0.868 rs864324 chr12:39122853 A/G cg26384229 chr12:38710491 ALG10B 0.55 14.11 0.49 1.44e-39 Heart rate; BRCA cis rs7607369 0.526 rs4674322 chr2:219513782 C/T cg02176678 chr2:219576539 TTLL4 0.47 9.52 0.35 3.39e-20 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg12165864 chr7:66369176 NA -0.46 -10.34 -0.38 2.74e-23 Corneal structure; BRCA cis rs312274 0.515 rs312273 chr12:41247742 A/G cg17827154 chr12:41323612 CNTN1 0.41 9.92 0.37 1.1e-21 Metabolite levels (X-11787); BRCA cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs6714710 0.603 rs58546246 chr2:98521823 C/A cg26665480 chr2:98280029 ACTR1B 0.57 13.39 0.47 3.3e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg26384229 chr12:38710491 ALG10B 0.7 15.83 0.53 7.18e-48 Bladder cancer; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 14.09 0.49 1.82e-39 Alzheimer's disease; BRCA cis rs9287719 0.810 rs7601748 chr2:10785446 A/G cg00105475 chr2:10696890 NA 0.42 9.64 0.36 1.24e-20 Prostate cancer; BRCA cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg10057126 chr4:77819792 ANKRD56 0.65 14.81 0.51 6.83e-43 Emphysema distribution in smoking; BRCA cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg12863693 chr15:85201151 NMB 0.44 7.85 0.3 1.81e-14 Schizophrenia; BRCA cis rs9309473 0.583 rs35885918 chr2:73612234 T/C cg20560298 chr2:73613845 ALMS1 -0.46 -12.35 -0.44 1.4e-31 Metabolite levels; BRCA cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg12501888 chr15:85177176 SCAND2 0.35 8.44 0.32 2.16e-16 P wave terminal force; BRCA cis rs908922 0.676 rs2146120 chr1:152504200 A/T cg20991723 chr1:152506922 NA 0.38 7.84 0.3 1.88e-14 Hair morphology; BRCA trans rs1422110 0.616 rs6452689 chr5:85445059 A/T cg01787110 chr1:109008453 NBPF6 0.4 8.65 0.32 4.21e-17 Attention function in attention deficit hyperactive disorder; BRCA cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg18876405 chr7:65276391 NA -0.5 -11.19 -0.4 1.18e-26 Aortic root size; BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg19346786 chr7:2764209 NA -0.32 -9.6 -0.36 1.79e-20 Height; BRCA trans rs2797160 1.000 rs983543 chr6:126005767 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.01e-14 Endometrial cancer; BRCA cis rs9814567 1.000 rs13089966 chr3:134279197 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3740540 0.761 rs61870251 chr10:126284415 A/C cg04949429 chr10:126290192 LHPP -0.41 -8.96 -0.33 3.43e-18 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs3815308 0.530 rs2269880 chr19:2195611 T/C cg09261902 chr19:2140048 AP3D1 0.34 8.43 0.32 2.23e-16 Breast cancer; BRCA cis rs7520050 0.833 rs1085242 chr1:46544224 T/A cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.42e-19 Red blood cell count;Reticulocyte count; BRCA cis rs11122272 0.701 rs2491402 chr1:231494338 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -11.39 -0.41 1.79e-27 Hemoglobin concentration; BRCA cis rs2635047 0.875 rs2635040 chr18:44640972 G/T cg19077165 chr18:44547161 KATNAL2 -0.43 -8.97 -0.33 3.15e-18 Educational attainment; BRCA cis rs6964587 0.626 rs409 chr7:91556355 C/T cg17063962 chr7:91808500 NA 0.57 12.99 0.46 2.14e-34 Breast cancer; BRCA cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg00071950 chr4:10020882 SLC2A9 -0.5 -11.39 -0.41 1.76e-27 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg14004847 chr7:1930337 MAD1L1 -0.46 -8.85 -0.33 8.71e-18 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.908 rs71614449 chr4:120387055 C/T cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 7.15e-87 Chronic sinus infection; BRCA cis rs1577917 1.000 rs12201880 chr6:86627007 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA cis rs3820068 0.603 rs2236215 chr1:15892415 A/C cg17385448 chr1:15911702 AGMAT 0.4 8.6 0.32 6.09e-17 Systolic blood pressure; BRCA cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.33 9.06 0.34 1.56e-18 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg00409905 chr10:38381863 ZNF37A -0.5 -10.45 -0.38 1.03e-23 Extrinsic epigenetic age acceleration; BRCA trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg25482853 chr8:67687455 SGK3 1.01 17.39 0.57 1.01e-55 Lung disease severity in cystic fibrosis; BRCA cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg17158414 chr2:27665306 KRTCAP3 -0.3 -7.92 -0.3 1.07e-14 Total body bone mineral density; BRCA cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg11833968 chr6:79620685 NA -0.41 -9.17 -0.34 6.16e-19 Intelligence (multi-trait analysis); BRCA cis rs7523050 0.908 rs17621536 chr1:109396908 A/G cg08274380 chr1:109419600 GPSM2 0.84 12.92 0.46 4.12e-34 Fat distribution (HIV); BRCA cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 11.43 0.41 1.2100000000000001e-27 Height; BRCA trans rs8073060 0.586 rs8064895 chr17:34001121 T/C cg19694781 chr19:47549865 TMEM160 -1.04 -21.53 -0.65 9.91e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00166722 chr3:10149974 C3orf24 0.67 13.46 0.47 1.52e-36 Alzheimer's disease; BRCA trans rs6952808 0.723 rs4721287 chr7:2028663 A/C cg04565464 chr8:145669602 NFKBIL2 0.38 8.92 0.33 5.04e-18 Bipolar disorder and schizophrenia; BRCA cis rs1420338 0.933 rs6462533 chr7:34168028 G/A cg01275685 chr7:34179230 BMPER -0.51 -11.41 -0.41 1.37e-27 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg05283184 chr6:79620031 NA -0.43 -11.22 -0.41 8.77e-27 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg08470875 chr2:26401718 FAM59B -0.52 -7.99 -0.3 6.24e-15 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.1 0.46 6.97e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg18305652 chr10:134549665 INPP5A 0.49 11.17 0.4 1.39e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg03433033 chr1:76189801 ACADM 0.89 23.76 0.68 6.23e-90 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 12.04 0.43 2.97e-30 Personality dimensions; BRCA cis rs11608355 0.515 rs2241204 chr12:109972037 G/A cg05360138 chr12:110035743 NA 0.73 13.35 0.47 4.74e-36 Neuroticism; BRCA cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg06766960 chr11:133703094 NA -0.61 -12.51 -0.44 2.96e-32 Childhood ear infection; BRCA cis rs13053817 0.898 rs16987627 chr22:29835060 T/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.49 -9.74 -0.36 5.54e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs2354432 0.607 rs11587707 chr1:146707186 T/C cg25205988 chr1:146714368 CHD1L -0.91 -11.34 -0.41 2.84e-27 Mitochondrial DNA levels; BRCA cis rs8009147 1 rs8009147 chr14:104264662 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.37 -0.41 2.06e-27 Autism spectrum disorder or schizophrenia; BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg19318889 chr4:1322082 MAEA 0.36 7.93 0.3 9.58e-15 Longevity; BRCA cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg03425785 chr20:62221387 GMEB2 0.51 8.23 0.31 1.04e-15 Glioblastoma; BRCA cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -8.0 -0.3 5.96e-15 Personality dimensions; BRCA cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.65 0.61 1.3e-67 Smoking behavior; BRCA cis rs7818345 1.000 rs11780343 chr8:19290963 C/T cg11303988 chr8:19266685 CSGALNACT1 0.3 7.97 0.3 7.15e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg10932868 chr11:921992 NA 0.42 10.02 0.37 4.98e-22 Alzheimer's disease (late onset); BRCA cis rs9467773 1.000 rs9357010 chr6:26527945 C/G cg09904177 chr6:26538194 HMGN4 0.57 18.43 0.59 3.7e-61 Intelligence (multi-trait analysis); BRCA cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg02376097 chr19:46275166 DMPK 0.45 10.21 0.37 8.91e-23 Coronary artery disease; BRCA cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg11058730 chr11:34937778 PDHX;APIP -0.65 -15.08 -0.51 3.41e-44 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg20203395 chr5:56204925 C5orf35 -0.51 -10.03 -0.37 4.49e-22 Initial pursuit acceleration; BRCA cis rs17253792 0.545 rs12879705 chr14:56017684 C/G cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.07 0.34 1.44e-18 Resting heart rate; BRCA cis rs586533 0.801 rs651446 chr11:99496269 A/G cg22878054 chr11:99397252 CNTN5 0.32 7.95 0.3 8.3e-15 Depressive symptoms (multi-trait analysis); BRCA trans rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05039488 chr6:79577232 IRAK1BP1 0.46 10.53 0.38 5.02e-24 Brugada syndrome; BRCA cis rs738322 0.805 rs2235344 chr22:38518083 G/A cg20207973 chr22:38506712 BAIAP2L2 0.38 9.92 0.37 1.11e-21 Cutaneous nevi; BRCA cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg27446573 chr6:127587934 RNF146 0.86 19.7 0.61 7.62e-68 Breast cancer; BRCA trans rs35110281 0.633 rs4819292 chr21:45125223 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.71 0.33 2.63e-17 Mean corpuscular volume; BRCA cis rs4595586 0.545 rs969469 chr12:39366775 A/C cg26384229 chr12:38710491 ALG10B 0.41 9.21 0.34 4.52e-19 Morning vs. evening chronotype; BRCA cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg11366901 chr6:160182831 ACAT2 0.78 15.08 0.51 3.42e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs4363385 0.818 rs2339492 chr1:152985552 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.42 -0.32 2.39e-16 Inflammatory skin disease; BRCA cis rs7647973 0.626 rs11720705 chr3:49753788 A/G cg03060546 chr3:49711283 APEH 0.6 10.4 0.38 1.61e-23 Menarche (age at onset); BRCA cis rs4845875 0.514 rs198406 chr1:11897592 A/G cg24844545 chr1:11908347 NPPA -0.31 -8.08 -0.3 3.13e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg09263875 chr16:632152 PIGQ 0.74 21.36 0.65 7.95e-77 Height; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.7 0.57 2.51e-57 Platelet count; BRCA cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg03146154 chr1:46216737 IPP 0.45 10.08 0.37 2.88e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7903847 0.596 rs7922512 chr10:99155685 C/A cg08345082 chr10:99160200 RRP12 -0.3 -8.72 -0.33 2.41e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs858239 0.536 rs6956974 chr7:23252318 C/G cg23682824 chr7:23144976 KLHL7 -0.32 -8.2 -0.31 1.27e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg11663144 chr21:46675770 NA 0.6 13.98 0.48 5.86e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9486719 1.000 rs11757063 chr6:96884886 C/T cg06623918 chr6:96969491 KIAA0776 -0.68 -12.16 -0.43 9.25e-31 Migraine;Coronary artery disease; BRCA cis rs13082711 0.513 rs7612102 chr3:27372826 A/G cg02860705 chr3:27208620 NA -0.56 -10.69 -0.39 1.15e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg11766577 chr21:47581405 C21orf56 0.43 9.53 0.35 3.17e-20 Testicular germ cell tumor; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg22337977 chr21:31811175 KRTAP15-1 0.35 8.06 0.3 3.82e-15 HDL cholesterol; BRCA cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.28 -0.31 7.47e-16 Bipolar disorder; BRCA cis rs10752881 0.935 rs3935221 chr1:182969010 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.56 0.55 1.64e-51 Colorectal cancer; BRCA cis rs10089 1.000 rs3805612 chr5:127505316 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.63 14.56 0.5 1.15e-41 Ileal carcinoids; BRCA cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg08992911 chr2:238395768 MLPH 0.4 8.72 0.33 2.31e-17 Prostate cancer; BRCA cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg02175503 chr12:58329896 NA 0.49 10.38 0.38 2.01e-23 Intelligence (multi-trait analysis); BRCA cis rs7568458 0.709 rs2028898 chr2:85777270 G/A cg02493740 chr2:85810744 VAMP5 -0.54 -11.23 -0.41 8.17e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs4595586 0.545 rs7958118 chr12:39376685 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.61e-19 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.81 12.23 0.44 4.85e-31 Platelet count; BRCA cis rs13046373 0.535 rs1354866 chr21:31981559 A/T cg06468780 chr21:31798236 KRTAP13-3 0.34 8.66 0.32 3.99e-17 HDL cholesterol; BRCA cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg12863693 chr15:85201151 NMB -0.54 -11.18 -0.4 1.31e-26 Schizophrenia; BRCA cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs6963495 0.769 rs73192134 chr7:105189338 T/C cg19920283 chr7:105172520 RINT1 0.58 9.24 0.34 3.49e-19 Bipolar disorder (body mass index interaction); BRCA cis rs8062405 0.824 rs62034319 chr16:28532188 T/G cg16576597 chr16:28551801 NUPR1 0.3 8.48 0.32 1.6e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.500 rs7971957 chr12:34477558 C/T cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.27e-22 Morning vs. evening chronotype; BRCA trans rs6582630 0.519 rs11495700 chr12:38288240 A/G cg06521331 chr12:34319734 NA -0.53 -9.53 -0.35 3.32e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs4891159 0.757 rs11665518 chr18:74147054 C/T cg24786174 chr18:74118243 ZNF516 -0.75 -18.0 -0.58 6.43e-59 Longevity; BRCA cis rs2070488 1.000 rs3792527 chr3:38493212 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.56 0.63 1.72e-72 Electrocardiographic conduction measures; BRCA trans rs60843830 1.000 rs57542652 chr2:228088 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.47 0.5 3.09e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg27170947 chr2:26402098 FAM59B -0.67 -11.53 -0.42 4.46e-28 Gut microbiome composition (summer); BRCA cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg04990556 chr1:26633338 UBXN11 -0.47 -9.27 -0.34 2.76e-19 Granulocyte percentage of myeloid white cells; BRCA trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg15704280 chr7:45808275 SEPT13 0.62 10.34 0.38 2.9e-23 Axial length; BRCA cis rs2404602 0.735 rs437131 chr15:76781051 C/T cg23625390 chr15:77176239 SCAPER 0.52 12.95 0.46 3.33e-34 Blood metabolite levels; BRCA cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg15903213 chr10:43522190 NA 0.37 8.0 0.3 5.85e-15 Pediatric bone mineral content (radius); BRCA cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg18351406 chr4:77819688 ANKRD56 0.62 14.04 0.49 3.05e-39 Emphysema distribution in smoking; BRCA cis rs870825 0.616 rs7692367 chr4:185651056 T/C cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA trans rs9467711 0.659 rs35555795 chr6:26509382 C/T cg01620082 chr3:125678407 NA -0.7 -8.64 -0.32 4.42e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs113835537 0.529 rs60358007 chr11:66222353 G/A cg24851651 chr11:66362959 CCS 0.5 8.62 0.32 5.19e-17 Airway imaging phenotypes; BRCA cis rs61931739 0.500 rs11053185 chr12:34428857 A/G cg06521331 chr12:34319734 NA -0.52 -10.25 -0.38 6.04e-23 Morning vs. evening chronotype; BRCA cis rs4302748 0.862 rs59125899 chr7:36182857 G/A cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs798766 0.779 rs55895920 chr4:1735930 C/T cg10756475 chr4:1757242 NA 0.38 8.58 0.32 7.19e-17 Bladder cancer;Urinary bladder cancer; BRCA cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.16 -0.58 1.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg24324837 chr19:49891574 CCDC155 0.54 9.6 0.36 1.75e-20 Multiple sclerosis; BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -11.77 -0.42 4.46e-29 Tonsillectomy; BRCA cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg05340658 chr4:99064831 C4orf37 0.62 14.69 0.5 2.65e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg17971929 chr21:40555470 PSMG1 0.77 18.12 0.58 1.6e-59 Cognitive function; BRCA trans rs208520 0.690 rs4386800 chr6:66755242 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.98 20.73 0.63 2.22e-73 Exhaled nitric oxide output; BRCA cis rs6684514 1.000 rs66965793 chr1:156285814 G/A cg16558208 chr1:156270281 VHLL 0.36 8.36 0.31 4.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7172677 0.737 rs7163083 chr15:75442337 A/C cg14664628 chr15:75095509 CSK -0.37 -7.88 -0.3 1.46e-14 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs3733585 0.806 rs7375599 chr4:9954918 C/T cg26043149 chr18:55253948 FECH 0.39 8.89 0.33 6.31e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4728302 0.583 rs1424583 chr7:133159583 T/G cg10665199 chr7:133106180 EXOC4 0.47 10.09 0.37 2.48e-22 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs12612619 0.732 rs11681562 chr2:27250603 A/G cg00617064 chr2:27272375 NA -0.32 -8.45 -0.32 1.91e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg06697600 chr4:7070879 GRPEL1 0.59 9.98 0.37 6.68e-22 Monocyte percentage of white cells; BRCA cis rs12950390 0.853 rs11079791 chr17:45859099 C/T cg03474202 chr17:45855739 NA -0.46 -12.35 -0.44 1.47e-31 IgG glycosylation; BRCA cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.47 -0.47 1.33e-36 Developmental language disorder (linguistic errors); BRCA cis rs9811920 0.660 rs11719468 chr3:99671848 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -11.15 -0.4 1.6e-26 Axial length; BRCA cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.17 0.49 7.64e-40 Motion sickness; BRCA cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.2e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg24531977 chr5:56204891 C5orf35 -0.88 -17.68 -0.57 2.99e-57 Initial pursuit acceleration; BRCA cis rs7617773 0.780 rs7653336 chr3:48369464 T/A cg11946769 chr3:48343235 NME6 0.67 13.64 0.47 2.37e-37 Coronary artery disease; BRCA cis rs6545883 0.929 rs1838978 chr2:61540923 T/C cg15711740 chr2:61764176 XPO1 0.51 12.2 0.43 6.69e-31 Tuberculosis; BRCA cis rs2243480 1.000 rs2243480 chr7:65599196 C/T cg18252515 chr7:66147081 NA -1.0 -14.27 -0.49 2.76e-40 Diabetic kidney disease; BRCA cis rs3008870 0.583 rs11208978 chr1:67442210 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.89 -16.53 -0.55 2.17e-51 Lymphocyte percentage of white cells; BRCA cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 8.84 0.33 9.33e-18 Mean platelet volume; BRCA cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg06060754 chr5:176797920 RGS14 0.59 11.18 0.4 1.31e-26 Hemoglobin concentration;Hematocrit; BRCA cis rs9325144 0.600 rs11183505 chr12:38759110 G/T cg26384229 chr12:38710491 ALG10B -0.51 -12.16 -0.43 9.46e-31 Morning vs. evening chronotype; BRCA trans rs2840044 1.000 rs1671656 chr17:33939661 C/T cg19694781 chr19:47549865 TMEM160 -0.44 -10.24 -0.38 6.94e-23 Response to radiotherapy in cancer (late toxicity); BRCA trans rs877282 1.000 rs12773872 chr10:771939 T/C cg22713356 chr15:30763199 NA 1.31 26.42 0.72 1.54e-104 Uric acid levels; BRCA cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.75 -12.66 -0.45 6.21e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs587242 1.000 rs12727152 chr1:96915548 G/A cg10631902 chr5:14652156 NA 0.4 9.94 0.37 9.26e-22 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs12530845 0.623 rs77454235 chr7:135341862 T/C cg23117316 chr7:135346802 PL-5283 -0.4 -8.2 -0.31 1.35e-15 Red blood cell traits; BRCA cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg04317338 chr11:64019027 PLCB3 0.52 7.97 0.3 7.56e-15 Mean platelet volume; BRCA cis rs12478296 1.000 rs12478296 chr2:243048760 A/G cg06360820 chr2:242988706 NA 0.74 13.73 0.48 8.56e-38 Obesity-related traits; BRCA cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg07493874 chr5:1342172 CLPTM1L -0.5 -14.04 -0.49 3.14e-39 Lung cancer; BRCA cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg00071950 chr4:10020882 SLC2A9 0.64 15.96 0.53 1.61e-48 Bone mineral density; BRCA cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.7 0.36 7.47e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg19748678 chr4:122722346 EXOSC9 0.74 15.9 0.53 3.11e-48 Type 2 diabetes; BRCA cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7917772 0.503 rs11191330 chr10:104306160 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.08 0.62 6.67e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7523273 0.606 rs2796263 chr1:207915978 T/C cg22525895 chr1:207977042 MIR29B2 0.48 12.22 0.44 5.47e-31 Schizophrenia; BRCA cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg11584989 chr19:19387371 SF4 0.61 13.9 0.48 1.5e-38 Bipolar disorder; BRCA cis rs7945705 0.782 rs3763918 chr11:8819683 T/A cg21881798 chr11:8931708 C11orf17;ST5 0.49 10.62 0.39 2.21e-24 Hemoglobin concentration; BRCA cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg24692254 chr21:30365293 RNF160 -0.6 -15.11 -0.51 2.49e-44 Dental caries; BRCA cis rs754466 0.561 rs11002344 chr10:79709725 A/T cg17075019 chr10:79541650 NA -0.5 -7.83 -0.3 1.98e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2073300 0.609 rs6137938 chr20:23389127 C/G cg12062639 chr20:23401060 NAPB 0.94 13.03 0.46 1.46e-34 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1577917 0.958 rs13207354 chr6:86700263 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.77 -0.42 4.5e-29 Response to antipsychotic treatment; BRCA cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.64 -0.36 1.25e-20 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.534 rs11053005 chr12:34091626 A/C cg26384229 chr12:38710491 ALG10B 0.68 14.09 0.49 1.77e-39 Morning vs. evening chronotype; BRCA cis rs2882667 0.894 rs1433008 chr5:138333664 T/C cg04439458 chr5:138467593 SIL1 -0.34 -9.47 -0.35 5.33e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg00750074 chr16:89608354 SPG7 0.37 9.66 0.36 1.05e-20 Multiple myeloma (IgH translocation); BRCA cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.22 -0.37 8.46e-23 Psoriasis; BRCA trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg27661571 chr11:113659931 NA -0.83 -12.11 -0.43 1.55e-30 Hip circumference adjusted for BMI; BRCA cis rs1868673 1.000 rs9784281 chr3:150159779 C/G cg04908077 chr3:150187338 NA -0.33 -8.82 -0.33 1.09e-17 Waist circumference; BRCA cis rs9747201 0.925 rs11867806 chr17:80072049 A/G cg01777586 chr17:80163174 CCDC57 -0.41 -8.28 -0.31 7.21e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11105298 0.891 rs10777184 chr12:89919568 C/T cg00757033 chr12:89920650 WDR51B 0.54 10.87 0.39 2.32e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9287719 0.601 rs6751436 chr2:10723862 C/T cg00105475 chr2:10696890 NA 0.47 10.48 0.38 7.94e-24 Prostate cancer; BRCA trans rs1005277 0.579 rs2800485 chr10:38542588 G/A cg23533926 chr12:111358616 MYL2 -0.44 -9.19 -0.34 5.59e-19 Extrinsic epigenetic age acceleration; BRCA cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg13628971 chr7:2884303 GNA12 0.38 8.42 0.32 2.39e-16 Height; BRCA cis rs7659604 0.628 rs3828485 chr4:122722368 G/A cg20573242 chr4:122745356 CCNA2 0.49 10.77 0.39 5.75e-25 Type 2 diabetes; BRCA trans rs11098499 0.754 rs11732087 chr4:120239831 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.33 0.38 3.04e-23 Corneal astigmatism; BRCA cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg18904891 chr8:8559673 CLDN23 0.64 12.57 0.45 1.54e-32 Obesity-related traits; BRCA cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -18.56 -0.59 7.93e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs16867321 0.950 rs12472841 chr2:181491840 C/A cg23363182 chr2:181467187 NA -0.45 -8.58 -0.32 6.96e-17 Obesity; BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07343612 chr16:622815 PIGQ -0.68 -22.79 -0.67 1.27e-84 Height; BRCA cis rs9304742 0.962 rs1808106 chr19:53452944 T/G cg09915433 chr19:53449742 NA -0.81 -19.97 -0.62 2.5e-69 Psoriasis; BRCA cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg03264133 chr6:25882463 NA 0.72 16.63 0.55 7.45e-52 Blood metabolite levels; BRCA cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg15839431 chr19:19639596 YJEFN3 -0.41 -9.13 -0.34 9.05e-19 Bipolar disorder; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg16606324 chr3:10149918 C3orf24 0.56 10.91 0.4 1.64e-25 Alzheimer's disease; BRCA trans rs208520 0.661 rs207090 chr6:66783963 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs10751667 0.600 rs11246376 chr11:999622 C/T cg06064525 chr11:970664 AP2A2 -0.29 -8.56 -0.32 8.47e-17 Alzheimer's disease (late onset); BRCA cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg23895963 chr12:117471115 NA 0.5 9.47 0.35 5.37e-20 Subcortical brain region volumes;Hippocampal volume; BRCA trans rs11098499 1.000 rs7659194 chr4:120207147 T/G cg25214090 chr10:38739885 LOC399744 0.49 10.87 0.4 2.29e-25 Corneal astigmatism; BRCA cis rs7264396 0.790 rs12480622 chr20:34234620 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.31 -0.49 1.65e-40 Total cholesterol levels; BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg21782813 chr7:2030301 MAD1L1 -0.33 -9.54 -0.35 3.06e-20 Bipolar disorder and schizophrenia; BRCA cis rs8114671 0.836 rs17404569 chr20:33674077 A/C cg07148914 chr20:33460835 GGT7 -0.42 -9.11 -0.34 1.09e-18 Height; BRCA cis rs1401999 1.000 rs6804242 chr3:183659463 A/T cg20387954 chr3:183756860 HTR3D 0.44 10.0 0.37 5.71e-22 Anterior chamber depth; BRCA cis rs1557765 0.527 rs10832782 chr11:17397273 G/C cg04705435 chr11:17411270 KCNJ11 0.34 7.84 0.3 1.95e-14 Body mass index;Social communication problems; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg18402987 chr7:1209562 NA 0.43 8.08 0.3 3.13e-15 Longevity;Endometriosis; BRCA cis rs7772486 0.790 rs2247206 chr6:146216184 C/T cg23711669 chr6:146136114 FBXO30 0.67 15.72 0.53 2.45e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs6121246 0.559 rs1062794 chr20:30381758 G/C cg13852791 chr20:30311386 BCL2L1 0.94 22.82 0.67 9.51e-85 Mean corpuscular hemoglobin; BRCA cis rs1018836 0.923 rs12545279 chr8:91636373 C/G cg16814680 chr8:91681699 NA -0.51 -10.66 -0.39 1.53e-24 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg11764359 chr7:65958608 NA 0.75 16.82 0.55 8.27e-53 Aortic root size; BRCA cis rs2304069 0.954 rs6579767 chr5:149406271 C/T cg12661370 chr5:149340060 SLC26A2 0.56 8.3 0.31 6.09e-16 HIV-1 control; BRCA cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg12011299 chr4:100065546 ADH4 0.43 10.82 0.39 3.46e-25 Alcohol dependence; BRCA cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg25173405 chr17:45401733 C17orf57 0.52 11.1 0.4 2.79e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg23711669 chr6:146136114 FBXO30 0.73 16.88 0.56 3.73e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs10871290 0.551 rs3863435 chr16:74465396 C/G cg01733217 chr16:74700730 RFWD3 -0.52 -13.09 -0.46 7.62e-35 Breast cancer; BRCA trans rs11165623 0.792 rs1931180 chr1:96914049 C/T cg10631902 chr5:14652156 NA -0.52 -16.97 -0.56 1.36e-53 Hip circumference;Waist circumference; BRCA cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg11062466 chr8:58055876 NA 0.4 7.85 0.3 1.74e-14 Developmental language disorder (linguistic errors); BRCA cis rs3809566 0.963 rs12148057 chr15:63331509 A/T cg12160578 chr15:63334699 TPM1 -0.42 -8.53 -0.32 1.04e-16 Platelet count; BRCA cis rs250677 0.687 rs250678 chr5:148434830 C/T cg23229984 chr5:148520753 ABLIM3 0.35 8.69 0.33 3.04e-17 Breast cancer; BRCA cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg06640241 chr16:89574553 SPG7 0.56 12.3 0.44 2.25e-31 Multiple myeloma (IgH translocation); BRCA cis rs2559856 1.000 rs2695285 chr12:102089043 G/A cg12924262 chr12:102091054 CHPT1 0.38 8.6 0.32 6.38e-17 Blood protein levels; BRCA cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -11.25 -0.41 6.26e-27 Schizophrenia; BRCA cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg07414643 chr4:187882934 NA -0.24 -8.04 -0.3 4.31e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs243505 1.000 rs243522 chr7:148420509 A/G cg09806900 chr7:148480153 CUL1 -0.4 -8.37 -0.31 3.73e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17685 0.816 rs11763076 chr7:75765963 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.68 -0.32 3.18e-17 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs3942852 0.622 rs6485806 chr11:48102806 A/G cg15704280 chr7:45808275 SEPT13 0.5 9.26 0.34 3.15e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs7246967 0.673 rs8103012 chr19:22879285 C/T cg23217946 chr19:22817039 ZNF492 0.46 8.46 0.32 1.87e-16 Bronchopulmonary dysplasia; BRCA cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg12463550 chr7:65579703 CRCP -0.38 -8.13 -0.31 2.28e-15 Aortic root size; BRCA cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg01939980 chr4:1354348 KIAA1530 0.32 9.07 0.34 1.41e-18 Longevity; BRCA cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.22e-26 Bipolar disorder; BRCA cis rs477692 0.905 rs544217 chr10:131420584 A/G cg24747557 chr10:131355152 MGMT -0.31 -7.89 -0.3 1.28e-14 Response to temozolomide; BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg01262667 chr19:19385393 TM6SF2 -0.42 -10.68 -0.39 1.35e-24 Tonsillectomy; BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.58 -9.93 -0.37 1.03e-21 Gut microbiome composition (summer); BRCA cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg22834771 chr12:69754056 YEATS4 -0.37 -9.05 -0.34 1.69e-18 Blood protein levels; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg02951883 chr7:2050386 MAD1L1 -0.6 -14.85 -0.51 4.73e-43 Bipolar disorder and schizophrenia; BRCA cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23248424 chr5:179741104 GFPT2 -0.67 -14.24 -0.49 3.72e-40 Height; BRCA cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg04756594 chr16:24857601 SLC5A11 0.34 8.31 0.31 5.53e-16 Intelligence (multi-trait analysis); BRCA cis rs7249142 0.512 rs12981160 chr19:19298099 T/A cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.37 -7.91 -0.3 1.12e-14 IgG glycosylation; BRCA cis rs7772486 0.837 rs2474354 chr6:146323795 T/A cg23711669 chr6:146136114 FBXO30 0.64 14.42 0.5 5.1e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg09060608 chr5:178986726 RUFY1 0.55 12.66 0.45 6.24e-33 Lung cancer; BRCA cis rs2645694 0.651 rs2703128 chr4:77819187 C/G cg03477792 chr4:77819574 ANKRD56 0.62 14.81 0.51 6.91e-43 Emphysema distribution in smoking; BRCA cis rs501916 0.833 rs11629796 chr15:48045248 A/G cg16110827 chr15:48056943 SEMA6D -0.44 -9.38 -0.35 1.14e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs4423214 0.879 rs1792282 chr11:71135166 G/A cg05163923 chr11:71159392 DHCR7 -0.51 -10.24 -0.38 6.61e-23 Vitamin D levels; BRCA cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.26 -0.34 2.96e-19 Colorectal cancer; BRCA cis rs11577318 1.000 rs11577318 chr1:26601570 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.4 -0.32 2.87e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg09462578 chr12:12878428 APOLD1 -0.69 -11.85 -0.42 2.08e-29 Systemic lupus erythematosus; BRCA cis rs887829 0.641 rs10179094 chr2:234597825 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.35 -8.67 -0.32 3.66e-17 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs9790314 0.715 rs980976 chr3:160771668 T/G cg03342759 chr3:160939853 NMD3 -0.51 -9.79 -0.36 3.62e-21 Morning vs. evening chronotype; BRCA cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg24130564 chr14:104152367 KLC1 0.4 9.19 0.34 5.61e-19 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs507080 0.845 rs509641 chr11:118558952 T/C cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA cis rs8017423 0.904 rs11623741 chr14:90804474 C/T cg14092571 chr14:90743983 NA -0.33 -7.87 -0.3 1.57e-14 Mortality in heart failure; BRCA cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.62 -13.89 -0.48 1.63e-38 Multiple sclerosis; BRCA trans rs8002861 0.935 rs4942256 chr13:44455920 A/T cg17145862 chr1:211918768 LPGAT1 0.73 19.3 0.61 1.01e-65 Leprosy; BRCA cis rs897080 0.552 rs1067377 chr2:44648239 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.56 0.35 2.59e-20 Height; BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg22920501 chr2:26401640 FAM59B -0.65 -11.29 -0.41 4.42e-27 Gut microbiome composition (summer); BRCA cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg04450456 chr4:17643702 FAM184B 0.41 12.47 0.44 4.22e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11758351 0.660 rs77130538 chr6:26210723 T/C cg01420254 chr6:26195488 NA 0.55 8.58 0.32 7.05e-17 Gout;Renal underexcretion gout; BRCA cis rs6704768 0.545 rs5004510 chr2:233679275 A/C cg08000102 chr2:233561755 GIGYF2 -0.78 -17.16 -0.56 1.52e-54 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg25208724 chr1:156163844 SLC25A44 0.59 11.95 0.43 7.53e-30 Testicular germ cell tumor; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.61 -12.72 -0.45 3.34e-33 Lymphocyte counts; BRCA cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg26647111 chr11:31128758 NA -0.44 -9.61 -0.36 1.61e-20 Red blood cell count; BRCA cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg06532163 chr17:45867833 NA 0.39 8.08 0.3 3.17e-15 IgG glycosylation; BRCA trans rs1493916 0.748 rs1941684 chr18:31304421 C/G cg15819921 chr19:927150 ARID3A -0.43 -8.32 -0.31 5.49e-16 Life satisfaction; BRCA cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg05283184 chr6:79620031 NA -0.43 -11.08 -0.4 3.33e-26 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.754 rs702324 chr6:146008793 A/G cg05347473 chr6:146136440 FBXO30 -0.42 -7.92 -0.3 1.08e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs2629540 0.824 rs1552345 chr10:126477406 A/G cg08799069 chr10:126477246 METTL10 -0.54 -11.85 -0.42 1.97e-29 Cocaine dependence; BRCA cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.57 0.39 3.5e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg08000102 chr2:233561755 GIGYF2 -0.64 -14.0 -0.48 5.16e-39 Coronary artery disease; BRCA cis rs6456156 0.792 rs10946212 chr6:167515947 C/G cg07741184 chr6:167504864 NA 0.31 8.94 0.33 4.11e-18 Primary biliary cholangitis; BRCA cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg03264133 chr6:25882463 NA 0.73 16.65 0.55 5.4e-52 Blood metabolite levels; BRCA cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.51e-36 High light scatter reticulocyte count; BRCA cis rs2599510 0.811 rs2710628 chr2:32758353 A/C cg02381751 chr2:32503542 YIPF4 0.41 8.29 0.31 6.85e-16 Interleukin-18 levels; BRCA cis rs36051895 0.632 rs11793886 chr9:5125469 A/G cg02405213 chr9:5042618 JAK2 -0.49 -8.9 -0.33 5.81e-18 Pediatric autoimmune diseases; BRCA trans rs2262909 0.962 rs12609368 chr19:22263996 T/C cg17074339 chr11:11642133 GALNTL4 0.42 8.15 0.31 1.93e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA trans rs4714291 0.698 rs2983144 chr6:40046724 G/A cg02267698 chr19:7991119 CTXN1 -0.44 -8.85 -0.33 8.61e-18 Strep throat; BRCA cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg22638593 chr5:131593259 PDLIM4 0.32 7.86 0.3 1.7e-14 Acylcarnitine levels; BRCA cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05535760 chr7:792225 HEATR2 0.87 14.93 0.51 1.94e-43 Cerebrospinal P-tau181p levels; BRCA cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.65 -10.28 -0.38 4.77e-23 Lung cancer in ever smokers; BRCA cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.76 -12.68 -0.45 5.04e-33 Schizophrenia; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg10729496 chr3:10149963 C3orf24 0.46 8.61 0.32 5.75e-17 Alzheimer's disease; BRCA cis rs877282 0.786 rs11253392 chr10:788768 G/A cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.23 0.34 3.99e-19 Resting heart rate; BRCA cis rs1421811 0.509 rs7733428 chr5:32689850 G/A cg16267343 chr5:32710456 NPR3 0.63 11.96 0.43 7.05e-30 Blood pressure; BRCA cis rs477692 0.875 rs7091540 chr10:131420276 C/T cg05714579 chr10:131428358 MGMT -0.56 -13.71 -0.48 1.07e-37 Response to temozolomide; BRCA cis rs11098499 0.722 rs10006192 chr4:120263022 T/C cg09307838 chr4:120376055 NA 0.6 13.0 0.46 1.91e-34 Corneal astigmatism; BRCA trans rs35110281 0.667 rs7282122 chr21:45082365 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.16 0.31 1.73e-15 Mean corpuscular volume; BRCA cis rs9815354 0.723 rs77572508 chr3:41938044 C/A cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.71e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.37 -0.38 2.18e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 24.7 0.7 4.42e-95 Platelet count; BRCA cis rs7020830 0.858 rs67036212 chr9:37133538 A/G cg14294708 chr9:37120828 ZCCHC7 1.2 38.04 0.83 2.49e-166 Schizophrenia; BRCA cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg21395723 chr22:39101663 GTPBP1 0.39 8.33 0.31 4.9e-16 Menopause (age at onset); BRCA cis rs3892630 0.588 rs7245709 chr19:33242755 C/T cg22980127 chr19:33182716 NUDT19 0.92 20.75 0.63 1.6e-73 Red blood cell traits; BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.33e-19 Tonsillectomy; BRCA cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg08000102 chr2:233561755 GIGYF2 -0.62 -13.31 -0.47 7.64e-36 Coronary artery disease; BRCA cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg00990874 chr7:1149470 C7orf50 -0.52 -9.49 -0.35 4.61e-20 Bronchopulmonary dysplasia; BRCA cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg10802521 chr3:52805072 NEK4 -0.33 -9.13 -0.34 8.81e-19 Bipolar disorder; BRCA cis rs7607369 0.609 rs13391398 chr2:219282429 A/G cg02176678 chr2:219576539 TTLL4 0.42 10.85 0.39 2.79e-25 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs9790314 0.521 rs1450522 chr3:161077630 A/G cg03342759 chr3:160939853 NMD3 -0.78 -17.38 -0.57 1.13e-55 Morning vs. evening chronotype; BRCA cis rs1997103 1.000 rs4947504 chr7:55409428 T/C cg17469321 chr7:55412551 NA 0.5 9.55 0.35 2.71e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4953318 0.577 rs67087783 chr2:46363544 C/T cg12428440 chr2:46370979 PRKCE 0.5 10.53 0.38 5.1900000000000004e-24 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.04 -0.4 4.7e-26 IgG glycosylation; BRCA cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg16230307 chr14:35515116 FAM177A1 0.74 15.5 0.52 3.27e-46 Psoriasis; BRCA cis rs12458462 0.892 rs12456692 chr18:77482189 C/T cg11879182 chr18:77439856 CTDP1 0.65 13.74 0.48 7.88e-38 Monocyte count; BRCA cis rs11758351 0.866 rs77889957 chr6:26207435 A/G cg01420254 chr6:26195488 NA 0.53 8.54 0.32 9.95e-17 Gout;Renal underexcretion gout; BRCA cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.31e-15 Aortic root size; BRCA cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs12711979 0.904 rs12329356 chr2:3868533 G/C cg17052675 chr2:3827356 NA -0.43 -11.52 -0.41 4.81e-28 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.51 0.35 3.85e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs10504073 0.647 rs10105794 chr8:50012793 G/C cg00325661 chr8:49890786 NA 0.39 11.34 0.41 2.81e-27 Blood metabolite ratios; BRCA cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg16482183 chr6:26056742 HIST1H1C 0.5 10.46 0.38 9.27e-24 Height; BRCA cis rs9393777 0.513 rs6904071 chr6:27047256 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -8.29 -0.31 6.81e-16 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.67 -16.55 -0.55 1.78e-51 Chronic sinus infection; BRCA trans rs12310956 0.532 rs11052935 chr12:33970946 C/T cg26384229 chr12:38710491 ALG10B 0.52 11.22 0.41 8.84e-27 Morning vs. evening chronotype; BRCA cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg06238570 chr21:40685208 BRWD1 -0.46 -9.19 -0.34 5.6e-19 Cognitive function; BRCA cis rs7633770 0.769 rs3796371 chr3:46667224 C/T cg11219411 chr3:46661640 NA 0.7 19.14 0.6 6.79e-65 Coronary artery disease; BRCA cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg14844989 chr11:31128820 NA -0.45 -9.52 -0.35 3.53e-20 Red blood cell count; BRCA cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg07148914 chr20:33460835 GGT7 0.46 9.9 0.36 1.35e-21 Height; BRCA cis rs7617773 0.780 rs6442111 chr3:48312060 G/C cg11946769 chr3:48343235 NME6 0.62 13.51 0.47 9.11e-37 Coronary artery disease; BRCA cis rs6138458 0.828 rs6132785 chr20:24993414 T/C cg26195577 chr20:24973756 C20orf3 0.71 17.49 0.57 2.8e-56 Blood protein levels; BRCA cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg03717367 chr9:139980219 LOC100289341;MAN1B1 0.46 10.83 0.39 3.25e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs965469 0.947 rs7274193 chr20:3329750 C/T cg25506879 chr20:3388711 C20orf194 -0.55 -10.7 -0.39 1.07e-24 IFN-related cytopenia; BRCA cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA cis rs5758511 0.689 rs17478227 chr22:42654327 C/G cg00645731 chr22:42541494 CYP2D7P1 -0.5 -7.86 -0.3 1.66e-14 Birth weight; BRCA trans rs11722228 0.549 rs62288521 chr4:10099772 G/A cg26043149 chr18:55253948 FECH 1.09 23.3 0.68 2.09e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs1691799 0.867 rs1495497 chr12:66770020 A/T cg16791601 chr12:66731901 HELB -0.63 -17.15 -0.56 1.68e-54 White blood cell count (basophil); BRCA cis rs2880765 0.835 rs4344688 chr15:86043007 A/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.45 -0.32 1.92e-16 Coronary artery disease; BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.27 -0.41 5.58e-27 Gut microbiome composition (summer); BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg08470875 chr2:26401718 FAM59B -0.76 -12.04 -0.43 3.12e-30 Gut microbiome composition (summer); BRCA cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24110177 chr3:50126178 RBM5 -0.36 -9.59 -0.35 2e-20 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.935 rs366308 chr6:145814532 T/A cg23711669 chr6:146136114 FBXO30 0.64 15.05 0.51 4.81e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.818 rs1334849 chr1:153004652 A/G cg25856811 chr1:152973957 SPRR3 0.32 8.56 0.32 8.22e-17 Inflammatory skin disease; BRCA cis rs7647973 0.626 rs7649428 chr3:49868876 A/T cg07636037 chr3:49044803 WDR6 -0.49 -8.1 -0.31 2.79e-15 Menarche (age at onset); BRCA cis rs7560272 0.513 rs7558546 chr2:73937732 A/T cg20560298 chr2:73613845 ALMS1 0.34 8.67 0.32 3.68e-17 Schizophrenia; BRCA cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA cis rs2070488 0.804 rs7372452 chr3:38444298 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.61 15.77 0.53 1.5e-47 Electrocardiographic conduction measures; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg09177884 chr7:1199841 ZFAND2A -0.47 -10.08 -0.37 2.72e-22 Longevity;Endometriosis; BRCA trans rs57046232 0.552 rs6076987 chr20:6351417 A/C cg21095983 chr6:86352623 SYNCRIP 0.4 8.29 0.31 6.64e-16 Colorectal cancer; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg20801007 chr11:830320 EFCAB4A -0.49 -10.65 -0.39 1.72e-24 Mean platelet volume; BRCA cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg05084668 chr3:125655381 ALG1L -0.47 -8.1 -0.31 2.84e-15 Blood pressure (smoking interaction); BRCA cis rs7512552 0.839 rs12042229 chr1:150447398 A/G cg15654264 chr1:150340011 RPRD2 0.43 9.05 0.34 1.76e-18 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs3733585 0.657 rs62286568 chr4:10124889 C/T cg00071950 chr4:10020882 SLC2A9 -0.47 -10.69 -0.39 1.2e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4908768 0.501 rs6577499 chr1:8612104 C/G cg20416874 chr1:8611966 RERE 0.29 8.49 0.32 1.46e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1153858 0.945 rs16943246 chr15:45720597 G/A cg14582100 chr15:45693742 SPATA5L1 0.35 10.84 0.39 2.97e-25 Homoarginine levels; BRCA trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg03929089 chr4:120376271 NA -0.53 -8.82 -0.33 1.09e-17 Axial length; BRCA cis rs208520 0.802 rs208496 chr6:66930786 G/C cg07460842 chr6:66804631 NA -0.89 -15.7 -0.53 3.24e-47 Exhaled nitric oxide output; BRCA cis rs2997447 0.595 rs3008425 chr1:26385660 T/C cg19633962 chr1:26362018 EXTL1 -0.5 -9.06 -0.34 1.59e-18 QRS complex (12-leadsum); BRCA cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.643 rs579610 chr2:219327582 C/A cg02176678 chr2:219576539 TTLL4 0.39 10.4 0.38 1.6e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg00738919 chr7:1100172 C7orf50 0.46 7.82 0.3 2.18e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg13047869 chr3:10149882 C3orf24 0.59 12.13 0.43 1.26e-30 Alzheimer's disease; BRCA cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg13852791 chr20:30311386 BCL2L1 0.85 16.77 0.55 1.43e-52 Mean corpuscular hemoglobin; BRCA cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg24324837 chr19:49891574 CCDC155 0.52 9.35 0.35 1.43e-19 Multiple sclerosis; BRCA cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg14036092 chr11:66035641 RAB1B -0.35 -9.58 -0.35 2.08e-20 Gout; BRCA cis rs910316 0.763 rs175047 chr14:75479039 C/G cg08847533 chr14:75593920 NEK9 -0.84 -21.09 -0.64 2.39e-75 Height; BRCA trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg15704280 chr7:45808275 SEPT13 -0.7 -14.16 -0.49 8.71e-40 Coronary artery disease; BRCA cis rs2050392 0.737 rs7898978 chr10:30699800 T/C cg18806716 chr10:30721971 MAP3K8 0.58 13.56 0.47 5.49e-37 Inflammatory bowel disease; BRCA trans rs4650994 0.525 rs4651000 chr1:178532223 A/G cg05059571 chr16:84539110 KIAA1609 -0.56 -12.54 -0.44 2e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg21395723 chr22:39101663 GTPBP1 0.4 8.72 0.33 2.42e-17 Menopause (age at onset); BRCA cis rs7707921 0.881 rs2629744 chr5:81381997 A/T cg15871215 chr5:81402204 ATG10 -0.37 -8.07 -0.3 3.37e-15 Breast cancer; BRCA cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg05347473 chr6:146136440 FBXO30 0.39 7.93 0.3 9.59e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7737355 0.947 rs7724769 chr5:130954943 C/T cg06307176 chr5:131281290 NA 0.53 10.27 0.38 5.2e-23 Life satisfaction; BRCA cis rs561341 1.000 rs527256 chr17:30321293 C/G cg23018236 chr17:30244563 NA -0.64 -10.28 -0.38 4.62e-23 Hip circumference adjusted for BMI; BRCA cis rs13136331 0.680 rs2732206 chr4:88652504 T/A cg22416721 chr4:88570574 DMP1 -0.57 -13.64 -0.47 2.43e-37 Sitting height ratio; BRCA cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.47e-27 Extrinsic epigenetic age acceleration; BRCA cis rs17641971 0.662 rs1858312 chr8:49996521 G/A cg00325661 chr8:49890786 NA 0.39 10.77 0.39 5.97e-25 Blood metabolite levels; BRCA cis rs1011018 0.628 rs73158614 chr7:139436800 G/A cg03224163 chr7:139420300 HIPK2 -0.54 -9.23 -0.34 3.9e-19 Systolic blood pressure; BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14415214 chr11:2950403 PHLDA2 0.35 7.87 0.3 1.54e-14 Mosquito bite size; BRCA cis rs10911232 0.507 rs11582514 chr1:182992161 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.48e-53 Hypertriglyceridemia; BRCA cis rs7103648 0.864 rs10769264 chr11:47423340 C/T cg20307385 chr11:47447363 PSMC3 0.86 25.99 0.72 3.64e-102 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1011018 0.628 rs17262390 chr7:139454209 T/C cg03224163 chr7:139420300 HIPK2 -0.58 -8.8 -0.33 1.31e-17 Systolic blood pressure; BRCA cis rs2387326 0.671 rs11016104 chr10:129946512 G/A cg16087940 chr10:129947807 NA -0.46 -8.25 -0.31 8.89e-16 Select biomarker traits; BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.8 0.62 2.19e-68 Platelet count; BRCA cis rs877282 0.898 rs11253346 chr10:765313 A/G cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA cis rs4906332 1.000 rs11625172 chr14:103944912 G/A cg19000871 chr14:103996768 TRMT61A -0.35 -8.04 -0.3 4.21e-15 Coronary artery disease; BRCA cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.43 0.55 7.1e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg08219700 chr8:58056026 NA 0.58 9.7 0.36 7.56e-21 Developmental language disorder (linguistic errors); BRCA cis rs4481887 1.000 rs10736378 chr1:248455769 T/G cg00666640 chr1:248458726 OR2T12 0.31 8.31 0.31 5.74e-16 Common traits (Other); BRCA cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.54 10.13 0.37 1.84e-22 Lung cancer in ever smokers; BRCA cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg22676075 chr6:135203613 NA 0.45 8.89 0.33 6.22e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7178424 0.806 rs4775453 chr15:62217391 A/C cg00456672 chr15:62358751 C2CD4A 0.38 9.26 0.34 2.98e-19 Height; BRCA cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.79 0.33 1.4e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg13736514 chr6:26305472 NA -0.35 -12.08 -0.43 2.04e-30 Educational attainment; BRCA cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs2239547 0.522 rs2581805 chr3:52979050 T/C cg11645453 chr3:52864694 ITIH4 -0.46 -11.6 -0.42 2.36e-28 Schizophrenia; BRCA cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22857025 chr5:266934 NA -1.03 -20.11 -0.62 4.43e-70 Breast cancer; BRCA cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.28 -0.44 2.95e-31 Bipolar disorder; BRCA cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg20476274 chr7:133979776 SLC35B4 0.7 21.57 0.65 5.96e-78 Mean platelet volume; BRCA cis rs6435161 0.959 rs72926966 chr2:203493293 C/A cg18429434 chr2:203499731 FAM117B -0.43 -8.47 -0.32 1.73e-16 Total cholesterol levels; BRCA cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg06552810 chr11:31128660 NA -0.4 -8.82 -0.33 1.09e-17 Red blood cell count; BRCA cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg22800045 chr5:56110881 MAP3K1 0.69 11.06 0.4 3.72e-26 Type 2 diabetes; BRCA cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs66887589 1.000 rs66887589 chr4:120509279 T/C cg09307838 chr4:120376055 NA -0.44 -9.09 -0.34 1.18e-18 Diastolic blood pressure; BRCA cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg22862634 chr11:62369728 EML3;MTA2 0.54 11.02 0.4 5.73e-26 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs965469 0.779 rs6051746 chr20:3307290 C/G cg25506879 chr20:3388711 C20orf194 -0.45 -8.97 -0.33 3.33e-18 IFN-related cytopenia; BRCA cis rs2404602 0.575 rs11633309 chr15:76962349 C/A cg23625390 chr15:77176239 SCAPER -0.53 -11.31 -0.41 3.73e-27 Blood metabolite levels; BRCA cis rs6066825 0.644 rs761271 chr20:47315637 A/G cg18078177 chr20:47281410 PREX1 0.41 10.15 0.37 1.57e-22 Colorectal cancer; BRCA cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg08917208 chr2:24149416 ATAD2B 1.05 14.38 0.49 7.78e-41 Lymphocyte counts; BRCA cis rs6879260 1.000 rs1035411 chr5:179729519 A/G cg23221052 chr5:179740743 GFPT2 -0.65 -13.28 -0.47 1.03e-35 Height; BRCA cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg13770153 chr20:60521292 NA -0.44 -9.84 -0.36 2.37e-21 Body mass index; BRCA cis rs11098499 0.754 rs2036857 chr4:120249240 T/C cg09307838 chr4:120376055 NA 0.64 14.0 0.48 5.12e-39 Corneal astigmatism; BRCA cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.6 9.91 0.37 1.21e-21 Lung function (FEV1/FVC); BRCA trans rs2018683 0.707 rs4722877 chr7:28972906 A/G cg19402173 chr7:128379420 CALU -0.42 -9.85 -0.36 2.07e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs4713118 0.955 rs9380010 chr6:27683572 A/G cg20933634 chr6:27740509 NA 0.44 8.45 0.32 2.04e-16 Parkinson's disease; BRCA cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs68170813 0.559 rs2107318 chr7:106845969 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.46 -0.32 1.78e-16 Coronary artery disease; BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.71 13.29 0.47 9.21e-36 Gut microbiome composition (summer); BRCA cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg04511125 chr2:88470314 THNSL2 0.77 11.17 0.4 1.35e-26 Plasma clusterin levels; BRCA cis rs142958719 1 rs142958719 chr5:131232959 G/A cg06307176 chr5:131281290 NA -0.53 -10.19 -0.37 1.06e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg14004847 chr7:1930337 MAD1L1 -0.42 -8.04 -0.3 4.51e-15 Bipolar disorder and schizophrenia; BRCA cis rs939658 1.000 rs34286854 chr15:79454374 C/T cg17916960 chr15:79447300 NA -0.43 -10.63 -0.39 2e-24 Refractive error; BRCA cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg11663144 chr21:46675770 NA -0.5 -9.89 -0.36 1.42e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4074536 0.574 rs6693356 chr1:116296510 T/A cg21648376 chr1:116311395 CASQ2 -0.48 -8.48 -0.32 1.53e-16 QRS duration; BRCA trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.35 0.44 1.44e-31 Corneal astigmatism; BRCA cis rs1580019 0.961 rs11768506 chr7:32494788 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.09 0.54 3.59e-49 Cognitive ability; BRCA cis rs13064411 0.660 rs1872747 chr3:113175785 T/A cg18753928 chr3:113234510 CCDC52 -0.56 -10.15 -0.37 1.5e-22 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08704250 chr15:31115839 NA -0.36 -8.92 -0.33 4.76e-18 Huntington's disease progression; BRCA cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.2 0.31 1.3e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg15839431 chr19:19639596 YJEFN3 -0.43 -8.93 -0.33 4.53e-18 Bipolar disorder; BRCA cis rs2762353 0.935 rs1165213 chr6:25799676 A/G cg12310025 chr6:25882481 NA 0.51 12.25 0.44 3.7e-31 Blood metabolite levels; BRCA cis rs10788264 0.569 rs7089468 chr10:124019052 T/C cg09507567 chr10:124027408 NA 0.39 8.36 0.31 3.87e-16 Total body bone mineral density; BRCA cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.71 12.32 0.44 1.94e-31 Lung cancer in ever smokers; BRCA cis rs7633857 0.595 rs7640874 chr3:160672617 T/A cg03342759 chr3:160939853 NMD3 -0.51 -10.43 -0.38 1.31e-23 Educational attainment (years of education); BRCA cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg05623727 chr3:50126028 RBM5 -0.38 -8.21 -0.31 1.2e-15 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs8017423 0.740 rs8003095 chr14:90680643 A/T cg04374321 chr14:90722782 PSMC1 0.73 19.21 0.61 2.79e-65 Mortality in heart failure; BRCA cis rs698833 0.692 rs786410 chr2:44731156 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.45 0.38 1.06e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11644478 chr21:40555479 PSMG1 -0.82 -18.5 -0.59 1.61e-61 Cognitive function; BRCA cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg08999081 chr20:33150536 PIGU 0.42 11.59 0.42 2.5e-28 Coronary artery disease; BRCA cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg21385522 chr1:16154831 NA 0.46 8.38 0.31 3.46e-16 Dilated cardiomyopathy; BRCA cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg12311346 chr5:56204834 C5orf35 -0.73 -14.47 -0.5 3.11e-41 Initial pursuit acceleration; BRCA cis rs312273 0.631 rs1442189 chr12:41364503 A/T cg17827154 chr12:41323612 CNTN1 -0.39 -10.09 -0.37 2.69e-22 Bipolar disorder; BRCA cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg24812749 chr6:127587940 RNF146 -0.68 -15.39 -0.52 1.08e-45 Breast cancer; BRCA cis rs17270561 0.553 rs6456696 chr6:25741408 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs9296092 0.538 rs62405948 chr6:33522753 A/C cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA trans rs6951245 1.000 rs78896566 chr7:1080182 C/G cg13565492 chr6:43139072 SRF -0.79 -11.12 -0.4 2.25e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg00071950 chr4:10020882 SLC2A9 0.54 13.11 0.46 5.88e-35 Bone mineral density; BRCA cis rs1568889 1.000 rs12797155 chr11:28290866 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 13.94 0.48 9.54e-39 Bipolar disorder; BRCA trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.43 0.35 7.46e-20 Intelligence (multi-trait analysis); BRCA cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -9.82 -0.36 2.72e-21 Neuroticism; BRCA cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg18404041 chr3:52824283 ITIH1 -0.29 -8.68 -0.32 3.31e-17 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Alcohol dependence; BRCA cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.45 -7.99 -0.3 6.35e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6545883 0.826 rs2694651 chr2:61588642 T/C cg15711740 chr2:61764176 XPO1 0.5 12.19 0.43 6.78e-31 Tuberculosis; BRCA cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg13319975 chr6:146136371 FBXO30 0.35 8.07 0.3 3.44e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2880765 0.835 rs7180923 chr15:86050890 A/T cg10818794 chr15:86012489 AKAP13 -0.32 -8.95 -0.33 3.95e-18 Coronary artery disease; BRCA cis rs10193935 0.901 rs2088281 chr2:42672731 A/G cg27598129 chr2:42591480 NA 0.87 13.96 0.48 7.25e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs858239 0.539 rs10279194 chr7:23191083 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs9640161 0.750 rs1983440 chr7:150023941 G/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.56 -13.95 -0.48 8.75e-39 Blood protein levels;Circulating chemerin levels; BRCA cis rs908922 0.676 rs1856119 chr1:152512483 A/G cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA trans rs6598955 0.671 rs12088858 chr1:26643708 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.22 -0.52 7.28e-45 Obesity-related traits; BRCA cis rs9341808 0.718 rs9294171 chr6:80839815 C/T cg08355045 chr6:80787529 NA 0.37 9.28 0.34 2.66e-19 Sitting height ratio; BRCA cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg16325326 chr1:53192061 ZYG11B -0.65 -16.18 -0.54 1.39e-49 Monocyte count; BRCA cis rs7640424 0.652 rs12152307 chr3:107861766 T/C cg09227934 chr3:107805635 CD47 -0.42 -8.63 -0.32 4.99e-17 Body mass index; BRCA trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.09 16.64 0.55 6.15e-52 Hemostatic factors and hematological phenotypes; BRCA cis rs7903847 0.642 rs11189172 chr10:99135215 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.28 -0.31 7.46e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg12193833 chr17:30244370 NA -0.58 -8.78 -0.33 1.54e-17 Hip circumference adjusted for BMI; BRCA cis rs7539409 0.651 rs10747407 chr1:84314754 G/A cg10977910 chr1:84465055 TTLL7 0.7 10.51 0.38 6.2e-24 Alzheimer's disease; BRCA trans rs1997103 0.954 rs2177809 chr7:55378125 T/C cg20935933 chr6:143382018 AIG1 0.6 11.43 0.41 1.15e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg22307029 chr19:49891270 CCDC155 0.54 9.03 0.34 2.04e-18 Multiple sclerosis; BRCA cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.85 0.3 1.76e-14 Depression; BRCA cis rs8062405 1.000 rs4451951 chr16:28836205 T/C cg16576597 chr16:28551801 NUPR1 0.3 8.45 0.32 2.03e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.05e-15 Melanoma; BRCA cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg22307297 chr20:60903441 LAMA5 -0.35 -9.82 -0.36 2.65e-21 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs17401966 0.931 rs4846205 chr1:10310214 A/T cg19773385 chr1:10388646 KIF1B -0.36 -7.89 -0.3 1.27e-14 Hepatocellular carcinoma; BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.14 0.31 2.12e-15 Tonsillectomy; BRCA cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg27446573 chr6:127587934 RNF146 0.88 20.71 0.63 2.59e-73 Breast cancer; BRCA cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg26384229 chr12:38710491 ALG10B 0.68 16.29 0.54 3.53e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg21782813 chr7:2030301 MAD1L1 0.32 8.52 0.32 1.18e-16 Bipolar disorder and schizophrenia; BRCA trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg11707556 chr5:10655725 ANKRD33B 0.42 9.35 0.35 1.46e-19 Coronary artery disease; BRCA cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg18446336 chr7:2847575 GNA12 -0.41 -10.25 -0.38 6.39e-23 Height; BRCA cis rs3806843 0.741 rs4912597 chr5:140106857 C/G cg16179182 chr5:140090404 VTRNA1-1 0.45 10.34 0.38 2.9e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs13082711 0.555 rs73149363 chr3:27265394 C/A cg02860705 chr3:27208620 NA 0.56 10.64 0.39 1.93e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2549003 1.000 rs13170412 chr5:131823519 A/G cg02551604 chr5:131831745 NA -0.4 -13.94 -0.48 9.43e-39 Asthma (sex interaction); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg09177884 chr7:1199841 ZFAND2A -0.52 -11.02 -0.4 5.56e-26 Longevity;Endometriosis; BRCA cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg23422044 chr7:1970798 MAD1L1 -0.56 -9.67 -0.36 9.51e-21 Neuroticism; BRCA cis rs9467711 0.606 rs28360517 chr6:26602453 A/G cg12826209 chr6:26865740 GUSBL1 0.61 8.07 0.3 3.52e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7975161 0.572 rs4964226 chr12:104570489 A/G cg25273343 chr12:104657179 TXNRD1 -0.52 -9.09 -0.34 1.24e-18 Toenail selenium levels; BRCA cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 19.47 0.61 1.19e-66 Smoking behavior; BRCA trans rs60843830 1.000 rs9213 chr2:218386 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 13.92 0.48 1.12e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg08219700 chr8:58056026 NA -0.54 -8.89 -0.33 6.33e-18 Developmental language disorder (linguistic errors); BRCA cis rs6484504 0.652 rs494464 chr11:31386150 C/T cg14844989 chr11:31128820 NA 0.44 9.65 0.36 1.14e-20 Red blood cell count; BRCA cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg17366294 chr4:99064904 C4orf37 0.54 11.58 0.42 2.76e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs9400271 0.632 rs9398191 chr6:109586561 C/T cg01475377 chr6:109611718 NA -0.43 -10.4 -0.38 1.58e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg09658497 chr7:2847517 GNA12 -0.42 -8.67 -0.32 3.68e-17 Height; BRCA cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg22467129 chr15:76604101 ETFA -0.41 -9.02 -0.34 2.13e-18 Blood metabolite levels; BRCA cis rs72772090 0.710 rs11750399 chr5:96077940 A/G cg24982541 chr5:96078678 CAST -0.46 -8.07 -0.3 3.42e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.07e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14442939 chr10:27389572 ANKRD26 0.69 9.28 0.34 2.68e-19 Breast cancer; BRCA cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg26384229 chr12:38710491 ALG10B 0.73 17.17 0.56 1.28e-54 Bladder cancer; BRCA cis rs7914558 1.000 rs4917380 chr10:104775335 C/G cg04362960 chr10:104952993 NT5C2 0.43 10.54 0.38 4.81e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1371614 0.545 rs3769136 chr2:27168743 C/T cg00617064 chr2:27272375 NA -0.32 -8.36 -0.31 3.84e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg25237894 chr2:233734115 C2orf82 0.4 11.45 0.41 1.01e-27 Coronary artery disease; BRCA cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg06212747 chr3:49208901 KLHDC8B 0.46 9.38 0.35 1.16e-19 Parkinson's disease; BRCA cis rs1030877 1.000 rs1030877 chr2:105910513 G/A cg02079111 chr2:105885981 TGFBRAP1 0.72 17.38 0.57 1.07e-55 Obesity-related traits; BRCA cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg08896387 chr1:24191740 FUCA1 -0.24 -7.93 -0.3 1e-14 Immature fraction of reticulocytes; BRCA trans rs57221529 0.709 rs4957056 chr5:570105 T/C cg25482853 chr8:67687455 SGK3 1.02 17.46 0.57 4.04e-56 Lung disease severity in cystic fibrosis; BRCA trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.14 0.31 2.04e-15 Corneal astigmatism; BRCA cis rs4660306 0.961 rs7546268 chr1:45965340 T/C cg24296786 chr1:45957014 TESK2 0.42 8.42 0.32 2.52e-16 Homocysteine levels; BRCA cis rs1595825 0.891 rs74265511 chr2:198494782 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -8.23 -0.31 1.04e-15 Ulcerative colitis; BRCA cis rs10267417 0.603 rs13241328 chr7:19939232 G/A cg05791153 chr7:19748676 TWISTNB 0.43 7.98 0.3 6.59e-15 Night sleep phenotypes; BRCA cis rs4595586 0.545 rs4768526 chr12:39402898 A/G cg26384229 chr12:38710491 ALG10B 0.54 11.26 0.41 5.69e-27 Morning vs. evening chronotype; BRCA cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg06627628 chr2:24431161 ITSN2 -0.51 -8.2 -0.31 1.27e-15 Lymphocyte counts; BRCA cis rs7582180 0.629 rs2309796 chr2:100954385 C/T cg14675211 chr2:100938903 LONRF2 0.45 10.28 0.38 4.83e-23 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.818 rs10888526 chr1:153000311 G/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.34 -0.31 4.71e-16 Inflammatory skin disease; BRCA cis rs921968 0.541 rs664514 chr2:219329819 A/G cg02176678 chr2:219576539 TTLL4 0.46 11.88 0.43 1.57e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg12219531 chr12:120966889 COQ5 0.54 11.37 0.41 2.15e-27 High light scatter reticulocyte count; BRCA cis rs116095464 0.558 rs10065239 chr5:275288 C/T cg22857025 chr5:266934 NA -1.03 -19.77 -0.62 3.13e-68 Breast cancer; BRCA cis rs56399783 0.901 rs73047387 chr7:2774125 G/A cg23627948 chr7:2760692 NA 0.5 7.84 0.3 1.85e-14 Childhood ear infection; BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg02733842 chr7:1102375 C7orf50 -0.61 -11.53 -0.41 4.57e-28 Bronchopulmonary dysplasia; BRCA trans rs208520 0.661 rs6937856 chr6:66867468 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.54 -0.63 2.23e-72 Exhaled nitric oxide output; BRCA cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg03517284 chr6:25882590 NA -0.45 -9.29 -0.34 2.45e-19 Intelligence (multi-trait analysis); BRCA cis rs11764590 0.756 rs17132130 chr7:2108036 G/C cg23422044 chr7:1970798 MAD1L1 -0.44 -9.0 -0.34 2.54e-18 Neuroticism; BRCA trans rs7824557 0.614 rs2736277 chr8:11218893 C/T cg15556689 chr8:8085844 FLJ10661 -0.29 -7.83 -0.3 2.09e-14 Retinal vascular caliber; BRCA cis rs28830936 0.510 rs11070349 chr15:42085017 A/C cg17847044 chr15:42102381 MAPKBP1 -0.51 -19.51 -0.61 7e-67 Diastolic blood pressure; BRCA cis rs6714710 0.580 rs11680018 chr2:98479581 C/A cg26665480 chr2:98280029 ACTR1B 0.59 13.54 0.47 6.4e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.86e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4285028 0.747 rs58367397 chr3:121451700 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.91 -0.48 1.25e-38 Multiple sclerosis; BRCA cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg09998033 chr7:158218633 PTPRN2 -0.41 -9.49 -0.35 4.36e-20 Obesity-related traits; BRCA cis rs34779708 0.966 rs17591163 chr10:35465279 G/C cg03585969 chr10:35415529 CREM 0.57 11.63 0.42 1.65e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs10267417 0.603 rs1557774 chr7:19908777 A/G cg07541023 chr7:19748670 TWISTNB 0.45 8.2 0.31 1.3e-15 Night sleep phenotypes; BRCA cis rs6910061 0.750 rs16870965 chr6:11123550 G/A cg27233058 chr6:11094804 LOC221710 0.5 8.27 0.31 8e-16 Diabetic kidney disease; BRCA cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.87e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg00800038 chr16:89945340 TCF25 -0.7 -10.64 -0.39 1.87e-24 Skin colour saturation; BRCA cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA trans rs11098499 0.954 rs17009122 chr4:120362403 G/A cg25214090 chr10:38739885 LOC399744 0.57 12.94 0.46 3.6e-34 Corneal astigmatism; BRCA cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg00750074 chr16:89608354 SPG7 -0.33 -8.95 -0.33 3.68e-18 Multiple myeloma (IgH translocation); BRCA cis rs36051895 0.632 rs12337481 chr9:5134599 T/G cg02405213 chr9:5042618 JAK2 -0.46 -9.01 -0.34 2.43e-18 Pediatric autoimmune diseases; BRCA cis rs4481887 1.000 rs4360553 chr1:248467092 A/G cg00666640 chr1:248458726 OR2T12 0.33 9.43 0.35 7.61e-20 Common traits (Other); BRCA cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg02297831 chr4:17616191 MED28 0.36 8.33 0.31 4.84e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg00825309 chr19:58991885 ZNF446 -0.64 -14.27 -0.49 2.66e-40 Uric acid clearance; BRCA cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02018176 chr4:1364513 KIAA1530 0.4 8.17 0.31 1.6e-15 Longevity; BRCA cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.72 12.18 0.43 8.02e-31 Lung cancer in ever smokers; BRCA cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg01579765 chr21:45077557 HSF2BP -0.43 -11.79 -0.42 3.45e-29 Mean corpuscular volume; BRCA cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg00012203 chr2:219082015 ARPC2 -0.58 -12.23 -0.44 4.95e-31 Colorectal cancer; BRCA cis rs6120849 0.754 rs13433216 chr20:33616301 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.29 0.38 4.57e-23 Protein C levels; BRCA cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg10495392 chr1:46806563 NSUN4 -0.44 -8.22 -0.31 1.14e-15 Menopause (age at onset); BRCA cis rs477692 1.000 rs577227 chr10:131404528 C/T cg05714579 chr10:131428358 MGMT 0.54 12.72 0.45 3.5e-33 Response to temozolomide; BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg16230307 chr14:35515116 FAM177A1 0.73 14.85 0.51 4.44e-43 Psoriasis; BRCA cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.73 17.76 0.57 1.2e-57 Chronic sinus infection; BRCA cis rs12618769 0.597 rs12617721 chr2:99083892 G/T cg10123293 chr2:99228465 UNC50 -0.4 -8.12 -0.31 2.49e-15 Bipolar disorder; BRCA cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg03517284 chr6:25882590 NA -0.39 -8.23 -0.31 1.08e-15 Intelligence (multi-trait analysis); BRCA trans rs1997103 1.000 rs2177804 chr7:55410302 G/A cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9527 0.590 rs7912517 chr10:104905529 G/A cg04362960 chr10:104952993 NT5C2 0.45 10.28 0.38 4.8e-23 Arsenic metabolism; BRCA cis rs4689388 0.727 rs1801213 chr4:6293696 C/G cg25554036 chr4:6271136 WFS1 0.43 9.62 0.36 1.48e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18301423 chr5:131593218 PDLIM4 0.32 8.42 0.32 2.42e-16 Breast cancer; BRCA cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 15.63 0.53 7.54e-47 Smoking behavior; BRCA cis rs7617773 0.743 rs6804986 chr3:48363595 A/G cg11946769 chr3:48343235 NME6 0.63 13.47 0.47 1.45e-36 Coronary artery disease; BRCA cis rs12579753 1.000 rs7956826 chr12:82173365 A/G cg07988820 chr12:82153109 PPFIA2 -0.59 -9.41 -0.35 8.79e-20 Resting heart rate; BRCA cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg23033748 chr14:75592666 NEK9 -0.43 -10.11 -0.37 2.14e-22 Height; BRCA cis rs36051895 0.659 rs1576271 chr9:5039652 A/C cg02405213 chr9:5042618 JAK2 -0.48 -8.67 -0.32 3.42e-17 Pediatric autoimmune diseases; BRCA cis rs270601 0.955 rs273911 chr5:131661526 C/G cg07395648 chr5:131743802 NA -0.38 -8.29 -0.31 6.7e-16 Acylcarnitine levels; BRCA cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.22 7.87 0.3 1.49e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs7520050 0.751 rs2991975 chr1:46024526 A/G cg24296786 chr1:45957014 TESK2 0.5 11.85 0.42 2.05e-29 Red blood cell count;Reticulocyte count; BRCA cis rs6963495 0.818 rs73192115 chr7:105169605 T/A cg19920283 chr7:105172520 RINT1 0.59 9.46 0.35 5.64e-20 Bipolar disorder (body mass index interaction); BRCA cis rs17767294 0.614 rs72850302 chr6:28241398 A/G cg08851530 chr6:28072375 NA 1.14 10.35 0.38 2.5e-23 Parkinson's disease; BRCA cis rs4363385 0.747 rs4478766 chr1:152984906 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.2 -0.34 5.11e-19 Inflammatory skin disease; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13012494 chr21:47604986 C21orf56 0.45 9.42 0.35 8.04e-20 Testicular germ cell tumor; BRCA cis rs6545883 0.929 rs1186707 chr2:61673520 C/A cg15711740 chr2:61764176 XPO1 -0.53 -13.33 -0.47 6.2e-36 Tuberculosis; BRCA cis rs7523273 0.526 rs1204706 chr1:208021060 G/T cg22525895 chr1:207977042 MIR29B2 -0.46 -11.43 -0.41 1.13e-27 Schizophrenia; BRCA cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs999943 0.846 rs9357162 chr6:33613344 G/A cg14003231 chr6:33640908 ITPR3 0.64 14.26 0.49 2.91e-40 Obesity (extreme); BRCA cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg26384229 chr12:38710491 ALG10B 0.72 17.02 0.56 7.11e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs17376456 0.569 rs7721668 chr5:93290995 G/A cg25358565 chr5:93447407 FAM172A -0.51 -9.44 -0.35 6.68e-20 Diabetic retinopathy; BRCA cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg10932868 chr11:921992 NA 0.47 12.09 0.43 1.93e-30 Alzheimer's disease (late onset); BRCA cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.51 9.86 0.36 1.96e-21 Aortic root size; BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg04267008 chr7:1944627 MAD1L1 -0.47 -9.77 -0.36 4.22e-21 Schizophrenia; BRCA cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg17143192 chr8:8559678 CLDN23 0.5 9.72 0.36 6.54e-21 Obesity-related traits; BRCA cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.77e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg21280719 chr6:42927975 GNMT -0.29 -12.11 -0.43 1.54e-30 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs9858542 0.953 rs9853683 chr3:49512588 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.66 -0.36 1.04e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs208520 0.690 rs207119 chr6:66786408 C/T cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs11030122 0.702 rs12281293 chr11:3963814 C/T cg18678763 chr11:4115507 RRM1 -0.36 -8.17 -0.31 1.6e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs7582180 0.638 rs6734316 chr2:100976210 A/G cg14675211 chr2:100938903 LONRF2 0.43 9.45 0.35 6.54e-20 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg12310025 chr6:25882481 NA -0.54 -13.09 -0.46 7.43e-35 Blood metabolite levels; BRCA cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg26597838 chr10:835615 NA 0.89 13.86 0.48 2.29e-38 Eosinophil percentage of granulocytes; BRCA cis rs13082711 0.689 rs34641383 chr3:27320210 G/A cg02860705 chr3:27208620 NA 0.85 15.37 0.52 1.31e-45 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7100689 0.577 rs2342813 chr10:82046302 T/G cg01528321 chr10:82214614 TSPAN14 0.77 17.28 0.56 3.55e-55 Post bronchodilator FEV1; BRCA trans rs7647973 0.710 rs9869120 chr3:49624065 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.86 -0.3 1.65e-14 Menarche (age at onset); BRCA cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.44 0.57 5.49e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs926392 0.533 rs6129162 chr20:37683195 G/A cg16355469 chr20:37678765 NA 0.49 11.07 0.4 3.57e-26 Dialysis-related mortality; BRCA trans rs2562456 0.874 rs9304986 chr19:21682062 G/A cg25042112 chr7:64838748 ZNF92 0.44 8.18 0.31 1.5e-15 Pain; BRCA cis rs1975991 0.765 rs4381925 chr3:187952250 C/T cg15417654 chr3:187959138 LPP -0.34 -8.32 -0.31 5.18e-16 White matter integrity (bipolar disorder risk interaction); BRCA cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg20503657 chr10:835505 NA 0.9 13.79 0.48 4.67e-38 Eosinophil percentage of granulocytes; BRCA cis rs477692 0.673 rs579325 chr10:131363688 C/T cg05714579 chr10:131428358 MGMT 0.5 11.0 0.4 6.51e-26 Response to temozolomide; BRCA cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg18876405 chr7:65276391 NA -0.62 -15.24 -0.52 5.51e-45 Aortic root size; BRCA cis rs13136331 0.641 rs2732174 chr4:88682910 A/T cg22416721 chr4:88570574 DMP1 -0.5 -11.44 -0.41 1.04e-27 Sitting height ratio; BRCA cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg13271783 chr10:134563150 INPP5A -0.51 -9.59 -0.35 1.99e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7647973 0.626 rs1352889 chr3:49652148 T/C cg03060546 chr3:49711283 APEH 0.56 9.84 0.36 2.26e-21 Menarche (age at onset); BRCA cis rs4077515 0.577 rs3812584 chr9:139312719 C/T cg14169450 chr9:139327907 INPP5E -0.38 -8.92 -0.33 4.7e-18 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2303759 0.709 rs10411679 chr19:49826480 A/T cg24324837 chr19:49891574 CCDC155 0.47 7.94 0.3 9.35e-15 Multiple sclerosis; BRCA cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.28e-18 Motion sickness; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg13397359 chr6:42928475 GNMT 0.75 19.35 0.61 5.1e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs8054556 0.647 rs11649149 chr16:30008644 C/T cg06326092 chr16:30034487 C16orf92 0.35 8.67 0.32 3.69e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11644478 chr21:40555479 PSMG1 -0.85 -19.93 -0.62 4.19e-69 Cognitive function; BRCA cis rs7264396 0.563 rs6058312 chr20:34324484 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs72781680 0.848 rs56371415 chr2:23932603 C/G cg08917208 chr2:24149416 ATAD2B 1.05 14.25 0.49 3.4e-40 Lymphocyte counts; BRCA cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg05347473 chr6:146136440 FBXO30 0.41 8.27 0.31 7.88e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg03354898 chr7:1950403 MAD1L1 0.46 9.12 0.34 9.29e-19 Bipolar disorder and schizophrenia; BRCA cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg24642439 chr20:33292090 TP53INP2 0.68 15.49 0.52 3.59e-46 Coronary artery disease; BRCA cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg18016565 chr1:150552671 MCL1 -0.46 -10.68 -0.39 1.28e-24 Tonsillectomy; BRCA cis rs67460515 0.531 rs13315565 chr3:160754626 G/C cg03342759 chr3:160939853 NMD3 -0.62 -12.67 -0.45 5.55e-33 Parkinson's disease; BRCA trans rs2204008 0.659 rs4002655 chr12:38169881 T/G cg06521331 chr12:34319734 NA -0.5 -9.31 -0.35 1.97e-19 Bladder cancer; BRCA cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg15556689 chr8:8085844 FLJ10661 0.43 11.81 0.42 3.04e-29 Mood instability; BRCA trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg15704280 chr7:45808275 SEPT13 0.7 13.95 0.48 8.34e-39 Coronary artery disease; BRCA cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg06238570 chr21:40685208 BRWD1 -0.4 -8.11 -0.31 2.53e-15 Menarche (age at onset); BRCA cis rs17376456 0.877 rs10078194 chr5:93364310 A/C cg25358565 chr5:93447407 FAM172A 1.14 18.67 0.59 2.14e-62 Diabetic retinopathy; BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24531977 chr5:56204891 C5orf35 -0.87 -17.89 -0.58 2.43e-58 Type 2 diabetes; BRCA cis rs17685 0.712 rs6464994 chr7:75784668 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 5.04e-16 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg23533926 chr12:111358616 MYL2 -0.43 -8.97 -0.33 3.37e-18 Extrinsic epigenetic age acceleration; BRCA cis rs6840360 0.615 rs55932132 chr4:152463897 G/T cg22705602 chr4:152727874 NA -0.32 -8.03 -0.3 4.59e-15 Intelligence (multi-trait analysis); BRCA cis rs6120849 0.901 rs6060273 chr20:33744323 G/C cg24642439 chr20:33292090 TP53INP2 0.47 8.42 0.32 2.42e-16 Protein C levels; BRCA cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg22535103 chr8:58192502 C8orf71 -0.61 -13.17 -0.46 3.08e-35 Developmental language disorder (linguistic errors); BRCA cis rs7267979 1.000 rs4815420 chr20:25383979 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.08 -0.34 1.34e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg12310025 chr6:25882481 NA -0.58 -12.87 -0.45 7.09e-34 Intelligence (multi-trait analysis); BRCA cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg14343924 chr8:8086146 FLJ10661 -0.41 -8.73 -0.33 2.16e-17 Mood instability; BRCA cis rs4285028 0.747 rs10049060 chr3:121358448 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.69 13.56 0.47 5.6e-37 Multiple sclerosis; BRCA cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.83 0.3 1.99e-14 Tonsillectomy; BRCA cis rs9309473 0.606 rs6759452 chr2:73878352 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -8.41 -0.32 2.76e-16 Metabolite levels; BRCA cis rs6964587 0.869 rs7810391 chr7:91520227 G/A cg17063962 chr7:91808500 NA -0.53 -12.21 -0.43 5.86e-31 Breast cancer; BRCA cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg22903657 chr4:1355424 KIAA1530 -0.37 -7.99 -0.3 6.21e-15 Obesity-related traits; BRCA cis rs2806561 0.704 rs664301 chr1:23522522 C/T cg12483005 chr1:23474871 LUZP1 0.48 10.46 0.38 9.57e-24 Height; BRCA cis rs12618769 0.652 rs17513468 chr2:99235169 T/G cg10123293 chr2:99228465 UNC50 0.41 8.16 0.31 1.82e-15 Bipolar disorder; BRCA cis rs9815354 0.904 rs9848992 chr3:41875297 C/T cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs1577917 0.917 rs35738006 chr6:86646309 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.32 -0.47 6.68e-36 Response to antipsychotic treatment; BRCA trans rs7829975 0.688 rs13270194 chr8:8378102 T/C cg16141378 chr3:129829833 LOC729375 -0.32 -7.84 -0.3 1.9e-14 Mood instability; BRCA cis rs754466 0.580 rs2579176 chr10:79529350 A/G cg17075019 chr10:79541650 NA -0.81 -19.36 -0.61 4.53e-66 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9341808 0.718 rs12203867 chr6:80820833 G/T cg08355045 chr6:80787529 NA 0.37 9.35 0.35 1.43e-19 Sitting height ratio; BRCA trans rs7618501 0.521 rs55692411 chr3:49911155 G/A cg21659725 chr3:3221576 CRBN 0.36 8.92 0.33 4.89e-18 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.55e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs727479 0.502 rs4775932 chr15:51498539 A/G cg19946085 chr15:51559439 CYP19A1 -0.3 -8.44 -0.32 2.08e-16 Estradiol levels; BRCA cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -14.1 -0.49 1.71e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg01028140 chr2:1542097 TPO -0.6 -12.64 -0.45 7.84e-33 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs17253792 0.822 rs17746033 chr14:56061837 G/A cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs73086581 1.000 rs17215340 chr20:3970173 C/G cg02187196 chr20:3869020 PANK2 -0.47 -8.75 -0.33 1.86e-17 Response to antidepressants in depression; BRCA cis rs7077164 1.000 rs7077164 chr10:71583198 C/T cg07630274 chr10:71583235 COL13A1 0.26 8.25 0.31 8.93e-16 Non-alcoholic fatty liver disease histology (lobular); BRCA cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.6 -0.42 2.21e-28 Glomerular filtration rate (creatinine); BRCA cis rs7246657 0.943 rs34603719 chr19:37794528 T/G cg23950597 chr19:37808831 NA -0.72 -12.06 -0.43 2.65e-30 Coronary artery calcification; BRCA cis rs7397814 0.558 rs4764447 chr12:9579109 C/T cg27502298 chr12:9555721 NA 0.81 17.27 0.56 3.88e-55 IgG glycosylation; BRCA cis rs9788682 0.747 rs2568490 chr15:78738370 T/C cg24631222 chr15:78858424 CHRNA5 -0.48 -9.57 -0.35 2.37e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg14784868 chr12:69753453 YEATS4 0.53 13.73 0.48 8.56e-38 Blood protein levels; BRCA cis rs11098499 0.874 rs13139045 chr4:120168588 T/C cg09307838 chr4:120376055 NA 0.58 11.73 0.42 6.56e-29 Corneal astigmatism; BRCA cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.79 0.39 4.86e-25 Bipolar disorder; BRCA cis rs11792861 0.855 rs116127510 chr9:111868344 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.05 0.3 3.95e-15 Menarche (age at onset); BRCA cis rs10992471 0.528 rs4744133 chr9:95226702 C/T cg14631576 chr9:95140430 CENPP -0.35 -8.82 -0.33 1.11e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg12310025 chr6:25882481 NA -0.54 -12.02 -0.43 3.8e-30 Intelligence (multi-trait analysis); BRCA cis rs832540 0.669 rs832538 chr5:56200016 C/T cg22800045 chr5:56110881 MAP3K1 0.43 8.84 0.33 9.05e-18 Coronary artery disease; BRCA trans rs9291683 0.609 rs4622999 chr4:10003395 C/G cg26043149 chr18:55253948 FECH 0.38 8.3 0.31 6.27e-16 Bone mineral density; BRCA cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg07636037 chr3:49044803 WDR6 0.46 9.17 0.34 6.59e-19 Resting heart rate; BRCA cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg14993813 chr1:46806288 NSUN4 -0.47 -8.86 -0.33 7.67e-18 Menopause (age at onset); BRCA cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg22875332 chr1:76189707 ACADM -0.79 -21.75 -0.65 6.71e-79 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg22920501 chr2:26401640 FAM59B -0.81 -13.14 -0.46 4.44e-35 Gut microbiome composition (summer); BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.2 0.66 2.32e-81 Platelet count; BRCA cis rs3768617 0.528 rs10737241 chr1:183098208 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 17.54 0.57 1.59e-56 Fuchs's corneal dystrophy; BRCA cis rs9814567 0.752 rs13075117 chr3:134329535 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.52 15.9 0.53 3.46e-48 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.86 -14.22 -0.49 4.72e-40 Platelet count; BRCA cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 -0.38 -8.3 -0.31 6.36e-16 Tonsillectomy; BRCA cis rs2239547 0.522 rs6768844 chr3:53004620 A/G cg11645453 chr3:52864694 ITIH4 -0.44 -11.14 -0.4 1.8e-26 Schizophrenia; BRCA cis rs1865760 1.000 rs2071298 chr6:25914901 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 11.32 0.41 3.23e-27 Height; BRCA cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg11584989 chr19:19387371 SF4 0.64 13.49 0.47 1.14e-36 Bipolar disorder; BRCA cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6842047 0.563 rs10025990 chr4:187146258 T/C cg23442198 chr4:187126114 CYP4V2 0.78 8.26 0.31 8.71e-16 Blood protein levels; BRCA cis rs7927592 0.913 rs3740631 chr11:68341722 T/G cg20283391 chr11:68216788 NA -0.46 -8.97 -0.33 3.25e-18 Total body bone mineral density; BRCA cis rs61931739 0.500 rs7296061 chr12:34435009 A/G cg06521331 chr12:34319734 NA 0.55 10.24 0.38 6.77e-23 Morning vs. evening chronotype; BRCA cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg20887711 chr4:1340912 KIAA1530 0.6 13.23 0.46 1.8e-35 Longevity; BRCA cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.46 -0.35 5.64e-20 Body mass index; BRCA cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.65e-34 Asthma (sex interaction); BRCA cis rs72772090 0.710 rs11750399 chr5:96077940 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.8 -0.45 1.52e-33 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg24812749 chr6:127587940 RNF146 0.86 20.26 0.63 7.08e-71 Breast cancer; BRCA cis rs561341 1.000 rs548957 chr17:30302411 G/A cg23018236 chr17:30244563 NA -0.61 -10.05 -0.37 3.63e-22 Hip circumference adjusted for BMI; BRCA cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.03 0.54 7.54e-49 Smoking behavior; BRCA cis rs1580019 0.844 rs1901202 chr7:32503724 A/T cg06627557 chr7:32535165 LSM5;AVL9 0.9 20.0 0.62 1.77e-69 Cognitive ability; BRCA cis rs1635 0.655 rs10484542 chr6:28309753 C/T cg15743358 chr6:28303923 ZNF323 -0.64 -7.92 -0.3 1.07e-14 Schizophrenia; BRCA cis rs68170813 0.559 rs12536485 chr7:106978005 T/C cg02696742 chr7:106810147 HBP1 -0.55 -8.79 -0.33 1.4e-17 Coronary artery disease; BRCA cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg10932868 chr11:921992 NA 0.49 12.6 0.45 1.18e-32 Alzheimer's disease (late onset); BRCA cis rs6840258 1.000 rs767315 chr4:87960435 C/T cg08197287 chr4:87952173 AFF1 -0.45 -8.95 -0.33 3.72e-18 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.52 -11.04 -0.4 4.78e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg05340658 chr4:99064831 C4orf37 0.62 14.89 0.51 2.77e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs11190604 1.000 rs10883510 chr10:102297018 C/T cg07080220 chr10:102295463 HIF1AN 0.63 13.26 0.46 1.33e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs13006833 0.668 rs291458 chr2:191181481 A/C cg11845111 chr2:191398756 TMEM194B 0.34 7.81 0.3 2.37e-14 Urinary metabolites; BRCA cis rs7727544 0.547 rs10076758 chr5:131524299 A/G cg14196790 chr5:131705035 SLC22A5 0.37 9.05 0.34 1.72e-18 Blood metabolite levels; BRCA cis rs611744 0.647 rs7015513 chr8:109262570 A/C cg21045802 chr8:109455806 TTC35 0.35 7.95 0.3 8.59e-15 Dupuytren's disease; BRCA cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg12935359 chr14:103987150 CKB -0.46 -10.53 -0.38 4.9e-24 Body mass index; BRCA cis rs11112613 0.713 rs17041546 chr12:105950801 G/T cg03607813 chr12:105948248 NA -0.55 -10.9 -0.4 1.74e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs11098499 0.722 rs7673476 chr4:120248683 C/T cg09307838 chr4:120376055 NA 0.62 13.38 0.47 3.73e-36 Corneal astigmatism; BRCA cis rs6977660 0.714 rs10252597 chr7:19791171 G/T cg07541023 chr7:19748670 TWISTNB -0.64 -10.59 -0.39 3.04e-24 Thyroid stimulating hormone; BRCA cis rs754466 0.606 rs3740250 chr10:79580101 C/T cg17075019 chr10:79541650 NA -0.86 -23.36 -0.68 1.01e-87 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg00814883 chr7:100076585 TSC22D4 -0.48 -10.59 -0.39 2.94e-24 Platelet count; BRCA cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg11764359 chr7:65958608 NA -0.63 -13.48 -0.47 1.2e-36 Aortic root size; BRCA cis rs4919087 0.961 rs11189120 chr10:99069493 G/T cg25902810 chr10:99078978 FRAT1 0.52 11.67 0.42 1.17e-28 Monocyte count; BRCA cis rs826838 0.586 rs10785554 chr12:38628749 T/A cg26384229 chr12:38710491 ALG10B 0.43 10.28 0.38 4.63e-23 Heart rate; BRCA cis rs68170813 0.559 rs76646886 chr7:107034328 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.3 -0.31 6.28e-16 Coronary artery disease; BRCA cis rs4595586 0.545 rs2388177 chr12:39364403 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.34e-19 Morning vs. evening chronotype; BRCA cis rs3774749 0.565 rs2188151 chr3:50201924 A/C cg24110177 chr3:50126178 RBM5 0.3 7.84 0.3 1.9e-14 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.02 -0.3 5.01e-15 Aortic root size; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.58 12.19 0.43 6.92e-31 Lymphocyte counts; BRCA cis rs1595825 0.891 rs7595819 chr2:198543156 A/C cg19156104 chr2:198669113 PLCL1 0.43 7.95 0.3 8.55e-15 Ulcerative colitis; BRCA cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg26597838 chr10:835615 NA 1.3 21.79 0.65 4.02e-79 Eosinophil percentage of granulocytes; BRCA cis rs10876993 0.928 rs10082911 chr12:58104104 C/A cg18357645 chr12:58087776 OS9 0.46 13.3 0.47 7.96e-36 Celiac disease or Rheumatoid arthritis; BRCA trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.01 0.3 5.51e-15 Corneal astigmatism; BRCA cis rs3892630 0.588 rs7260037 chr19:33242701 G/A cg22980127 chr19:33182716 NUDT19 0.92 20.75 0.63 1.6e-73 Red blood cell traits; BRCA cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg26031613 chr14:104095156 KLC1 0.44 8.73 0.33 2.14e-17 Schizophrenia; BRCA cis rs921968 0.508 rs72965103 chr2:219312469 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -13.26 -0.46 1.28e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.26 -0.49 3.1e-40 Initial pursuit acceleration; BRCA cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg18964960 chr10:1102726 WDR37 0.61 8.12 0.31 2.48e-15 Eosinophil percentage of granulocytes; BRCA cis rs3008870 0.920 rs2755253 chr1:67470843 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.72 16.09 0.54 3.82e-49 Lymphocyte percentage of white cells; BRCA cis rs8180040 1.000 rs2302278 chr3:47361082 G/T cg27129171 chr3:47204927 SETD2 -0.62 -14.37 -0.49 8.49e-41 Colorectal cancer; BRCA cis rs10911232 0.542 rs12128323 chr1:183050087 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 16.95 0.56 1.78e-53 Hypertriglyceridemia; BRCA cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg03433033 chr1:76189801 ACADM 0.73 16.14 0.54 2.07e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17253792 0.822 rs10148122 chr14:56146694 G/T cg01858014 chr14:56050164 KTN1 -0.75 -10.26 -0.38 5.89e-23 Putamen volume; BRCA cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg13628971 chr7:2884303 GNA12 0.4 9.12 0.34 9.5e-19 Height; BRCA cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.92 -0.33 5.05e-18 Monocyte percentage of white cells; BRCA cis rs1005277 0.505 rs200931 chr10:38128434 A/C cg00409905 chr10:38381863 ZNF37A -0.49 -10.48 -0.38 7.85e-24 Extrinsic epigenetic age acceleration; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg05863683 chr7:1912471 MAD1L1 0.37 8.28 0.31 7.31e-16 Bipolar disorder and schizophrenia; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg19626725 chr5:178986131 RUFY1 -0.32 -9.75 -0.36 4.76e-21 Lung cancer; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg25703541 chr22:24373054 LOC391322 -0.66 -15.08 -0.51 3.37e-44 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs919433 0.713 rs6719729 chr2:198480072 G/A cg00792783 chr2:198669748 PLCL1 0.34 7.9 0.3 1.2e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs490234 0.616 rs2841325 chr9:128163620 C/G cg14078157 chr9:128172775 NA 0.36 8.2 0.31 1.34e-15 Mean arterial pressure; BRCA cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg26384229 chr12:38710491 ALG10B 0.66 15.1 0.51 2.91e-44 Bladder cancer; BRCA cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg18876405 chr7:65276391 NA -0.5 -11.13 -0.4 1.96e-26 Aortic root size; BRCA cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg08807101 chr21:30365312 RNF160 -0.57 -13.96 -0.48 7.81e-39 Dental caries; BRCA trans rs11165623 0.543 rs60982887 chr1:96989155 T/G cg10631902 chr5:14652156 NA -0.43 -12.07 -0.43 2.24e-30 Hip circumference;Waist circumference; BRCA cis rs832540 0.931 rs832536 chr5:56212595 C/T cg24531977 chr5:56204891 C5orf35 -0.42 -8.42 -0.32 2.43e-16 Coronary artery disease; BRCA cis rs9815354 0.812 rs73081361 chr3:41912535 G/A cg03022575 chr3:42003672 ULK4 0.71 9.74 0.36 5.4e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg24692254 chr21:30365293 RNF160 -0.48 -10.57 -0.39 3.64e-24 Pancreatic cancer; BRCA cis rs7917772 0.636 rs7894154 chr10:104524647 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.58 -0.39 3.11e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg04166393 chr7:2884313 GNA12 -0.42 -9.1 -0.34 1.12e-18 Height; BRCA cis rs36051895 0.659 rs12336577 chr9:5063690 T/A cg02405213 chr9:5042618 JAK2 -0.53 -9.56 -0.35 2.39e-20 Pediatric autoimmune diseases; BRCA cis rs2250402 0.510 rs2291619 chr15:40329033 C/T cg10636054 chr15:40330586 SRP14 -0.91 -13.26 -0.46 1.29e-35 Corneal curvature; BRCA cis rs875971 0.558 rs4433015 chr7:65639723 A/C cg11764359 chr7:65958608 NA -0.61 -13.28 -0.47 9.82e-36 Aortic root size; BRCA trans rs208520 0.874 rs208470 chr6:66916402 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.29 -0.54 3.62e-50 Exhaled nitric oxide output; BRCA cis rs6964587 0.967 rs34863529 chr7:91644341 C/G cg17063962 chr7:91808500 NA 0.54 12.41 0.44 7.86e-32 Breast cancer; BRCA cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg17691542 chr6:26056736 HIST1H1C 0.53 11.36 0.41 2.38e-27 Height; BRCA cis rs887829 0.569 rs4294999 chr2:234635467 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.86 -0.33 8.03e-18 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg00409905 chr10:38381863 ZNF37A -0.47 -10.18 -0.37 1.12e-22 Extrinsic epigenetic age acceleration; BRCA cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg21573476 chr21:45109991 RRP1B -0.34 -9.0 -0.34 2.61e-18 Mean corpuscular volume; BRCA cis rs11098499 0.588 rs6534149 chr4:120559292 T/G cg09307838 chr4:120376055 NA -0.53 -11.07 -0.4 3.59e-26 Corneal astigmatism; BRCA cis rs10751667 0.857 rs6597961 chr11:976677 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.81 -0.36 3.08e-21 Alzheimer's disease (late onset); BRCA cis rs1421811 0.532 rs72740626 chr5:32692220 G/C cg16267343 chr5:32710456 NPR3 0.65 12.48 0.44 3.91e-32 Blood pressure; BRCA cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg13256891 chr4:100009986 ADH5 -0.52 -9.64 -0.36 1.27e-20 Alcohol dependence; BRCA trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg23533926 chr12:111358616 MYL2 -0.41 -8.72 -0.33 2.47e-17 Extrinsic epigenetic age acceleration; BRCA cis rs9309711 0.772 rs9309714 chr2:3491830 G/C cg16153549 chr2:3496821 NA -0.44 -9.98 -0.37 7.04e-22 Neurofibrillary tangles; BRCA cis rs17376456 0.877 rs10044066 chr5:93437580 T/C cg21475434 chr5:93447410 FAM172A 0.66 9.05 0.34 1.75e-18 Diabetic retinopathy; BRCA trans rs2204008 0.837 rs1589395 chr12:38420405 C/T cg06521331 chr12:34319734 NA -0.46 -8.57 -0.32 8.05e-17 Bladder cancer; BRCA cis rs6087990 0.842 rs6119279 chr20:31330612 A/G cg13636640 chr20:31349939 DNMT3B 0.7 21.1 0.64 2.05e-75 Ulcerative colitis; BRCA cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg12756686 chr19:29218302 NA 0.38 8.03 0.3 4.58e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs3617 0.572 rs2256332 chr3:52855865 A/G cg11645453 chr3:52864694 ITIH4 -0.4 -10.68 -0.39 1.26e-24 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs96067 0.805 rs7522400 chr1:36613380 A/G cg24686825 chr1:36642396 MAP7D1 -0.45 -8.67 -0.32 3.61e-17 Corneal structure; BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg14196790 chr5:131705035 SLC22A5 0.33 8.64 0.32 4.66e-17 Breast cancer; BRCA cis rs4974559 0.739 rs28429103 chr4:1320023 G/A cg02980000 chr4:1222292 CTBP1 0.81 13.19 0.46 2.75e-35 Systolic blood pressure; BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg21226059 chr5:178986404 RUFY1 0.5 12.84 0.45 1.01e-33 Lung cancer; BRCA cis rs3806843 1.000 rs4151680 chr5:140186657 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs4988958 0.584 rs12712149 chr2:103045193 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma (childhood onset); BRCA cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg20887711 chr4:1340912 KIAA1530 0.59 13.07 0.46 9.07e-35 Longevity; BRCA cis rs7818345 0.967 rs7006702 chr8:19272533 G/C cg11303988 chr8:19266685 CSGALNACT1 0.31 8.26 0.31 8.36e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs4481887 0.927 rs12744455 chr1:248479960 A/G cg00666640 chr1:248458726 OR2T12 0.29 8.29 0.31 6.55e-16 Common traits (Other); BRCA trans rs2204008 0.774 rs11520237 chr12:38266978 G/A cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Bladder cancer; BRCA cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg08514558 chr10:81106712 PPIF 0.39 8.99 0.33 2.88e-18 Height; BRCA cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.71e-15 Uric acid levels; BRCA cis rs7809950 0.678 rs62483641 chr7:106901741 T/C cg23024343 chr7:107201750 COG5 -0.45 -8.95 -0.33 3.83e-18 Coronary artery disease; BRCA cis rs11997175 0.624 rs67643247 chr8:33700790 G/A ch.8.33884649F chr8:33765107 NA 0.37 8.09 0.3 3.02e-15 Body mass index; BRCA cis rs4660306 0.961 rs4660871 chr1:45995232 C/A cg24296786 chr1:45957014 TESK2 0.45 9.5 0.35 4.12e-20 Homocysteine levels; BRCA cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg20219911 chr3:52813652 ITIH1 0.3 8.21 0.31 1.18e-15 Bipolar disorder; BRCA cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg20790798 chr5:1857306 NA -0.39 -9.09 -0.34 1.2e-18 Cardiovascular disease risk factors; BRCA cis rs7011049 0.908 rs72640866 chr8:53843014 C/T cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg04166393 chr7:2884313 GNA12 0.42 9.1 0.34 1.09e-18 Height; BRCA cis rs17270561 0.609 rs1937127 chr6:25769872 G/T cg16482183 chr6:26056742 HIST1H1C -0.45 -9.0 -0.34 2.65e-18 Iron status biomarkers; BRCA cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg26617929 chr16:1858877 NA -0.45 -7.94 -0.3 9.45e-15 Glomerular filtration rate in chronic kidney disease; BRCA cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg03146154 chr1:46216737 IPP -0.44 -9.74 -0.36 5.58e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2404602 0.684 rs28895952 chr15:76856776 A/G cg23625390 chr15:77176239 SCAPER -0.54 -13.63 -0.47 2.7e-37 Blood metabolite levels; BRCA cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 17.21 0.56 8.14e-55 Hip circumference adjusted for BMI; BRCA cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg05347473 chr6:146136440 FBXO30 0.42 8.28 0.31 7.18e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs312273 0.806 rs1372538 chr12:41325578 C/T cg17827154 chr12:41323612 CNTN1 -0.43 -11.27 -0.41 5.23e-27 Bipolar disorder; BRCA cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg11764359 chr7:65958608 NA -0.64 -14.51 -0.5 1.83e-41 Aortic root size; BRCA cis rs9814567 1.000 rs1880376 chr3:134270347 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.64 13.63 0.47 2.48e-37 Lymphocyte counts; BRCA cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.73 0.42 6.43e-29 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg08754478 chr10:133766260 PPP2R2D -0.68 -13.52 -0.47 7.81e-37 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg16230307 chr14:35515116 FAM177A1 0.73 15.23 0.52 6.64e-45 Psoriasis; BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.14 -0.43 1.14e-30 Alzheimer's disease; BRCA cis rs6942756 1.000 rs67520056 chr7:128982075 A/G cg02491457 chr7:128862824 NA -0.72 -14.15 -0.49 9.48e-40 White matter hyperintensity burden; BRCA trans rs9329221 0.686 rs35406700 chr8:10244593 A/G cg15556689 chr8:8085844 FLJ10661 0.35 8.61 0.32 5.82e-17 Neuroticism; BRCA cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg18876405 chr7:65276391 NA 0.62 15.48 0.52 4.02e-46 Aortic root size; BRCA cis rs10782582 0.609 rs111914775 chr1:76319036 C/T cg03433033 chr1:76189801 ACADM -0.42 -8.63 -0.32 4.85e-17 Daytime sleep phenotypes; BRCA cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg10556349 chr10:835070 NA 0.64 9.31 0.35 1.97e-19 Eosinophil percentage of granulocytes; BRCA cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg19346786 chr7:2764209 NA -0.28 -8.85 -0.33 8.37e-18 Height; BRCA cis rs9463078 0.845 rs2396425 chr6:45177025 A/G cg25276700 chr6:44698697 NA -0.35 -7.97 -0.3 7.51e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7917772 0.582 rs10786684 chr10:104323028 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.5 -15.22 -0.52 6.9e-45 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg23708337 chr7:1209742 NA 0.52 10.22 0.37 8.38e-23 Longevity;Endometriosis; BRCA cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.54 0.38 4.59e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs636291 0.517 rs55935829 chr1:10540926 A/T cg17425144 chr1:10567563 PEX14 0.55 13.77 0.48 6e-38 Prostate cancer; BRCA cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg08704250 chr15:31115839 NA -0.34 -8.13 -0.31 2.31e-15 Huntington's disease progression; BRCA cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs524281 0.861 rs2889313 chr11:65966066 G/C cg16950941 chr11:66035639 RAB1B -0.39 -8.06 -0.3 3.88e-15 Electroencephalogram traits; BRCA trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg23505145 chr19:12996616 KLF1 0.56 12.75 0.45 2.49e-33 Prostate cancer (SNP x SNP interaction); BRCA trans rs7726839 0.561 rs72703050 chr5:582917 A/C cg25482853 chr8:67687455 SGK3 0.78 12.93 0.46 3.98e-34 Obesity-related traits; BRCA cis rs9942416 0.660 rs17649055 chr5:74984269 C/T cg19683494 chr5:74908142 NA 0.48 9.06 0.34 1.57e-18 Age-related disease endophenotypes; BRCA cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24549020 chr5:56110836 MAP3K1 0.66 13.54 0.47 6.71e-37 Initial pursuit acceleration; BRCA trans rs2204008 0.837 rs7308714 chr12:38274307 T/C cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Bladder cancer; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg22920501 chr2:26401640 FAM59B -0.64 -11.26 -0.41 6.05e-27 Gut microbiome composition (summer); BRCA cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg05472934 chr7:22766657 IL6 -0.59 -14.41 -0.5 5.87e-41 Lung cancer; BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg08888203 chr3:10149979 C3orf24 0.65 11.88 0.43 1.45e-29 Alzheimer's disease; BRCA cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg02734326 chr4:10020555 SLC2A9 0.36 7.87 0.3 1.53e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9815354 0.812 rs59146151 chr3:41949301 T/C cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA trans rs7824557 0.806 rs34171564 chr8:11095346 C/A cg15556689 chr8:8085844 FLJ10661 -0.35 -8.59 -0.32 6.47e-17 Retinal vascular caliber; BRCA cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs4908768 0.539 rs2100888 chr1:8659282 T/A cg20416874 chr1:8611966 RERE -0.28 -7.94 -0.3 9.16e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.48 0.32 1.53e-16 Electroencephalogram traits; BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.33 -0.31 5.01e-16 Total body bone mineral density; BRCA cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.61e-52 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9287719 0.839 rs11683335 chr2:10756665 C/G cg02196655 chr2:10830764 NOL10 -0.3 -8.07 -0.3 3.4e-15 Prostate cancer; BRCA cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg03433033 chr1:76189801 ACADM -0.76 -17.43 -0.57 5.73e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg08601574 chr20:25228251 PYGB -0.37 -8.91 -0.33 5.15e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg03188948 chr7:1209495 NA 0.45 8.22 0.31 1.14e-15 Longevity;Endometriosis; BRCA cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11890956 chr21:40555474 PSMG1 -0.84 -21.85 -0.65 1.78e-79 Cognitive function; BRCA cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs9649465 1.000 rs1506635 chr7:123317184 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs7917772 0.503 rs11191321 chr10:104293412 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg24006582 chr15:45444508 DUOX1 0.54 10.71 0.39 9.67e-25 Uric acid levels; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12711979 0.509 rs10195488 chr2:3824135 T/C cg17052675 chr2:3827356 NA -0.7 -23.65 -0.68 2.6e-89 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg23791538 chr6:167370224 RNASET2 0.43 10.61 0.39 2.57e-24 Crohn's disease; BRCA cis rs9457247 0.663 rs9457258 chr6:167444254 T/C cg07741184 chr6:167504864 NA 0.28 8.18 0.31 1.58e-15 Crohn's disease; BRCA cis rs3820928 1.000 rs7579961 chr2:227776976 T/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.8e-16 Pulmonary function; BRCA cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.48 -9.34 -0.35 1.55e-19 Chronic sinus infection; BRCA cis rs586533 0.801 rs669596 chr11:99499507 G/C cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg06271696 chr7:157225062 NA -0.37 -9.55 -0.35 2.72e-20 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg13319975 chr6:146136371 FBXO30 0.62 13.86 0.48 2.15e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg21782813 chr7:2030301 MAD1L1 0.36 9.79 0.36 3.37e-21 Bipolar disorder and schizophrenia; BRCA cis rs4713118 0.955 rs9380012 chr6:27684654 A/G cg20933634 chr6:27740509 NA 0.44 8.43 0.32 2.27e-16 Parkinson's disease; BRCA cis rs10883723 0.810 rs7074343 chr10:104283165 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.08 0.62 6.44e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs9287719 0.967 rs6727768 chr2:10757479 T/C cg00105475 chr2:10696890 NA 0.44 10.3 0.38 4.11e-23 Prostate cancer; BRCA cis rs72781680 0.898 rs113522526 chr2:24018476 C/T cg08917208 chr2:24149416 ATAD2B 0.88 12.68 0.45 5.05e-33 Lymphocyte counts; BRCA cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.47 0.57 3.66e-56 Bladder cancer; BRCA cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.59 12.24 0.44 4.39e-31 Monocyte percentage of white cells; BRCA cis rs17818399 0.815 rs62136873 chr2:46861237 G/A cg02822958 chr2:46747628 ATP6V1E2 0.45 8.02 0.3 4.96e-15 Height; BRCA cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg19077165 chr18:44547161 KATNAL2 -0.53 -11.33 -0.41 3.01e-27 Personality dimensions; BRCA cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.27 -0.41 5.18e-27 Colorectal cancer; BRCA cis rs7178424 1.000 rs12442212 chr15:62380482 A/C cg00456672 chr15:62358751 C2CD4A -0.35 -8.43 -0.32 2.35e-16 Height; BRCA cis rs10638925 1 rs10638925 chr3:194119749 C/CCATAAA cg00834899 chr3:194121120 GP5 0.45 9.22 0.34 4.11e-19 Platelet distribution width; BRCA cis rs2712184 0.868 rs1548946 chr2:217665368 C/T cg05032264 chr2:217675019 NA -0.43 -10.63 -0.39 2.04e-24 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs7246657 0.943 rs1559229 chr19:37876197 T/C cg14683738 chr19:37701593 ZNF585B 0.46 8.12 0.31 2.48e-15 Coronary artery calcification; BRCA trans rs11039798 0.920 rs9667596 chr11:48691193 T/C cg15704280 chr7:45808275 SEPT13 0.6 8.83 0.33 1.02e-17 Axial length; BRCA trans rs6011368 0.765 rs7270745 chr20:62892756 C/G cg13869341 chr1:15865 WASH5P -0.35 -7.94 -0.3 9.44e-15 Clozapine-induced cytotoxicity; BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg05793240 chr7:2802953 GNA12 -0.32 -7.82 -0.3 2.23e-14 Height; BRCA cis rs4787491 0.729 rs11642399 chr16:30059593 T/G cg06326092 chr16:30034487 C16orf92 0.37 9.48 0.35 4.82e-20 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2204008 0.774 rs4534658 chr12:38246783 G/A cg06521331 chr12:34319734 NA -0.48 -8.9 -0.33 5.63e-18 Bladder cancer; BRCA cis rs68170813 0.559 rs61406169 chr7:106903421 A/T cg02696742 chr7:106810147 HBP1 -0.52 -8.97 -0.33 3.36e-18 Coronary artery disease; BRCA cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg08807892 chr2:162101083 NA 0.72 16.5 0.55 3.35e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15506890 chr2:3487001 NA -0.57 -12.33 -0.44 1.67e-31 Neurofibrillary tangles; BRCA trans rs1459104 1.000 rs34965777 chr11:55238748 G/A cg15704280 chr7:45808275 SEPT13 0.67 8.35 0.31 4.13e-16 Body mass index; BRCA cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.69 0.39 1.18e-24 Motion sickness; BRCA trans rs8073060 0.586 rs72828038 chr17:33893908 C/A cg19694781 chr19:47549865 TMEM160 1.03 21.28 0.64 2.24e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1506636 1.000 rs1506636 chr7:123317140 C/T cg03229431 chr7:123269106 ASB15 0.59 13.19 0.46 2.59e-35 Plateletcrit;Platelet count; BRCA cis rs68170813 0.559 rs6965001 chr7:106933196 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.7 -0.33 2.87e-17 Coronary artery disease; BRCA cis rs2992756 0.663 rs2992757 chr1:18807137 T/C cg14356550 chr1:18808102 KLHDC7A -0.4 -8.22 -0.31 1.1e-15 Breast cancer; BRCA cis rs6446731 0.517 rs2071667 chr4:3269926 C/A cg08886695 chr4:3369023 RGS12 0.37 9.87 0.36 1.82e-21 Mean platelet volume; BRCA cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg08085267 chr17:45401833 C17orf57 -0.58 -11.98 -0.43 5.79e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9788721 0.836 rs17405217 chr15:78731149 C/T cg18825076 chr15:78729989 IREB2 -0.44 -8.37 -0.31 3.56e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.24 -0.31 9.98e-16 Colorectal cancer; BRCA cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 21.85 0.65 1.87e-79 Smoking behavior; BRCA cis rs1046896 0.503 rs12947062 chr17:80686370 A/G cg02711726 chr17:80685570 FN3KRP 0.68 16.5 0.55 3.31e-51 Glycated hemoglobin levels; BRCA trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.49 -0.32 1.4e-16 Extrinsic epigenetic age acceleration; BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 26.17 0.72 3.74e-103 Platelet count; BRCA cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg10523679 chr1:76189770 ACADM -0.55 -10.19 -0.37 1.04e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1372520 0.684 rs10008964 chr4:90744721 G/A cg15133208 chr4:90757351 SNCA -0.39 -7.97 -0.3 7.23e-15 Neuroticism; BRCA cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg05340658 chr4:99064831 C4orf37 0.62 14.99 0.51 1e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg13507429 chr1:18807550 KLHDC7A -0.44 -10.96 -0.4 9.55e-26 Breast cancer; BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.28 -0.31 7.16e-16 Total body bone mineral density; BRCA cis rs2762353 0.935 rs11754288 chr6:25776949 G/A cg03517284 chr6:25882590 NA 0.47 10.45 0.38 1.05e-23 Blood metabolite levels; BRCA cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 9.31 0.35 2.02e-19 Aortic root size; BRCA trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg03929089 chr4:120376271 NA 0.6 9.82 0.36 2.78e-21 Axial length; BRCA cis rs910316 0.935 rs175422 chr14:75627319 T/A cg11812906 chr14:75593930 NEK9 -0.63 -14.3 -0.49 1.84e-40 Height; BRCA cis rs2882667 0.894 rs10054478 chr5:138354075 G/A cg04439458 chr5:138467593 SIL1 -0.34 -9.23 -0.34 3.83e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg18404041 chr3:52824283 ITIH1 -0.38 -11.74 -0.42 5.84e-29 Bipolar disorder; BRCA cis rs7577696 0.597 rs212689 chr2:32437338 G/A cg02381751 chr2:32503542 YIPF4 0.47 8.58 0.32 7.11e-17 Inflammatory biomarkers; BRCA cis rs7607369 0.536 rs4646535 chr2:219664663 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.55 -0.39 4.18e-24 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg21226059 chr5:178986404 RUFY1 -0.36 -9.44 -0.35 6.86e-20 Lung cancer; BRCA trans rs208520 0.837 rs208509 chr6:66941706 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.82 -15.26 -0.52 4.4e-45 Exhaled nitric oxide output; BRCA cis rs67460515 0.892 rs2100238 chr3:161058055 T/A cg03342759 chr3:160939853 NMD3 -0.81 -19.0 -0.6 3.77e-64 Parkinson's disease; BRCA cis rs736408 0.812 rs9324 chr3:52825585 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.3 9.6 0.36 1.75e-20 Bipolar disorder; BRCA cis rs8005677 0.611 rs11624528 chr14:23459156 A/G cg23176270 chr14:23476067 C14orf93 0.46 9.35 0.35 1.46e-19 Cognitive ability (multi-trait analysis); BRCA cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.58 -0.35 2.17e-20 Tonsillectomy; BRCA cis rs7833986 0.501 rs72653986 chr8:57035048 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.46 7.85 0.3 1.79e-14 Height; BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg14196790 chr5:131705035 SLC22A5 0.32 8.46 0.32 1.86e-16 Breast cancer; BRCA cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.42e-68 Mean platelet volume; BRCA cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.72e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg20503657 chr10:835505 NA 1.04 17.17 0.56 1.32e-54 Eosinophil percentage of granulocytes; BRCA cis rs7131987 0.903 rs7974221 chr12:29399448 A/G cg09582351 chr12:29534625 ERGIC2 -0.39 -9.51 -0.35 3.89e-20 QT interval; BRCA cis rs887829 0.570 rs13002774 chr2:234593706 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.31 -0.31 5.65e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1113500 0.730 rs1361829 chr1:108593895 A/G cg06207961 chr1:108661230 NA -0.33 -7.91 -0.3 1.12e-14 Growth-regulated protein alpha levels; BRCA trans rs7615952 0.558 rs7641353 chr3:125339879 T/C cg07211511 chr3:129823064 LOC729375 -0.59 -10.63 -0.39 2.15e-24 Blood pressure (smoking interaction); BRCA cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.4 0.38 1.71e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs7208859 0.573 rs55661352 chr17:29045628 A/G cg13385521 chr17:29058706 SUZ12P 0.79 10.85 0.39 2.75e-25 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs9649465 0.935 rs7780086 chr7:123378471 C/A cg04330084 chr7:123175371 IQUB -0.33 -8.88 -0.33 6.76e-18 Migraine; BRCA cis rs7647973 1.000 rs2312462 chr3:49601255 A/G cg07636037 chr3:49044803 WDR6 0.66 14.19 0.49 6.13e-40 Menarche (age at onset); BRCA cis rs9325144 0.647 rs12231313 chr12:39101929 C/T cg26384229 chr12:38710491 ALG10B -0.48 -11.23 -0.41 7.66e-27 Morning vs. evening chronotype; BRCA cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg24060327 chr5:131705240 SLC22A5 -0.61 -11.54 -0.42 4.19e-28 Breast cancer; BRCA cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs28374715 0.510 rs8034073 chr15:41545613 A/C cg18705301 chr15:41695430 NDUFAF1 -0.51 -11.28 -0.41 4.73e-27 Ulcerative colitis; BRCA cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg00531865 chr16:30841666 NA -0.5 -11.66 -0.42 1.28e-28 Multiple myeloma; BRCA cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.48 0.5 2.79e-41 Motion sickness; BRCA cis rs477692 1.000 rs503660 chr10:131418999 A/G cg05714579 chr10:131428358 MGMT 0.53 12.51 0.44 2.76e-32 Response to temozolomide; BRCA cis rs2070488 0.965 rs2051215 chr3:38560345 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -19.35 -0.61 5.45e-66 Electrocardiographic conduction measures; BRCA trans rs8105895 0.825 rs62112369 chr19:22313901 C/T cg05197062 chr11:11642011 GALNTL4 -0.51 -8.24 -0.31 9.86e-16 Body mass index (change over time); BRCA cis rs11887277 0.507 rs6743539 chr2:27056239 A/G cg12368169 chr2:27073192 DPYSL5 -0.27 -8.01 -0.3 5.28e-15 Obesity-related traits; BRCA cis rs854765 0.565 rs4072738 chr17:17884547 A/C cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 15.38 0.52 1.25e-45 Total body bone mineral density; BRCA cis rs11608355 0.545 rs11609019 chr12:109895958 G/A cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg00071950 chr4:10020882 SLC2A9 -0.47 -10.97 -0.4 9.29e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg11050988 chr7:1952600 MAD1L1 -0.23 -7.82 -0.3 2.11e-14 Bipolar disorder and schizophrenia; BRCA cis rs6545883 0.894 rs2177962 chr2:61588070 T/A cg15711740 chr2:61764176 XPO1 0.5 12.29 0.44 2.54e-31 Tuberculosis; BRCA cis rs3749237 1.000 rs2307021 chr3:49765483 C/G cg03060546 chr3:49711283 APEH 0.52 10.81 0.39 3.85e-25 Resting heart rate; BRCA cis rs2594989 0.943 rs2594995 chr3:11369117 A/G cg01796438 chr3:11312864 ATG7 0.53 8.22 0.31 1.15e-15 Circulating chemerin levels; BRCA cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.3 0.38 4.05e-23 Aortic root size; BRCA cis rs12368653 0.701 rs238517 chr12:58117737 T/G cg18357645 chr12:58087776 OS9 0.36 9.98 0.37 6.69e-22 Multiple sclerosis; BRCA trans rs6479891 1.000 rs12413029 chr10:65189126 T/C cg14819942 chr15:35414228 NA 0.35 8.58 0.32 7.31e-17 Arthritis (juvenile idiopathic); BRCA cis rs9815354 0.812 rs73077386 chr3:41857652 A/G cg03022575 chr3:42003672 ULK4 0.68 9.45 0.35 6.07e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.18e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24110177 chr3:50126178 RBM5 0.4 10.85 0.39 2.73e-25 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.822 rs75555677 chr14:56096429 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs7809950 1.000 rs2520268 chr7:107191161 T/A cg23024343 chr7:107201750 COG5 -0.41 -9.13 -0.34 8.66e-19 Coronary artery disease; BRCA cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg06494592 chr3:125709126 NA -0.53 -8.27 -0.31 7.78e-16 Blood pressure (smoking interaction); BRCA cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg00012203 chr2:219082015 ARPC2 -0.57 -12.08 -0.43 2.08e-30 Colorectal cancer; BRCA cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg06115741 chr20:33292138 TP53INP2 0.36 8.01 0.3 5.64e-15 Glomerular filtration rate (creatinine); BRCA cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg08045932 chr20:61659980 NA 0.5 11.02 0.4 5.42e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs7647973 0.626 rs62260723 chr3:49872124 T/C cg03060546 chr3:49711283 APEH -0.6 -10.47 -0.38 8.64e-24 Menarche (age at onset); BRCA cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg12011299 chr4:100065546 ADH4 0.38 11.02 0.4 5.74e-26 Alcohol dependence; BRCA trans rs6598955 0.671 rs12086573 chr1:26574330 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs1003719 0.591 rs9636914 chr21:38589732 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.55 11.69 0.42 9.14e-29 Eye color traits; BRCA cis rs3845702 0.935 rs3845695 chr2:180796989 A/G cg01881094 chr2:180872142 CWC22 -0.68 -13.59 -0.47 3.76e-37 Schizophrenia; BRCA cis rs7474896 0.583 rs12783272 chr10:38024885 T/G cg25427524 chr10:38739819 LOC399744 -0.56 -9.54 -0.35 3.02e-20 Obesity (extreme); BRCA cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg21433313 chr16:3507492 NAT15 0.61 9.58 0.35 2.07e-20 Tuberculosis; BRCA cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg10523679 chr1:76189770 ACADM -0.62 -11.68 -0.42 1.05e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7592578 0.771 rs62181034 chr2:191354963 C/A cg11845111 chr2:191398756 TMEM194B -0.79 -14.92 -0.51 2.19e-43 Diastolic blood pressure; BRCA cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.1 0.37 2.45e-22 Bipolar disorder; BRCA cis rs57024841 0.500 rs6560652 chr9:139830940 C/T cg00693599 chr9:139836323 FBXW5 -0.4 -9.94 -0.37 9.59e-22 Beta-trace protein levels; BRCA cis rs17818399 0.533 rs4384837 chr2:46789514 A/G cg02822958 chr2:46747628 ATP6V1E2 0.48 9.97 0.37 7.59e-22 Height; BRCA cis rs3820928 0.692 rs2396434 chr2:227775223 G/T cg05526886 chr2:227700861 RHBDD1 -0.4 -8.34 -0.31 4.49e-16 Pulmonary function; BRCA cis rs250677 0.617 rs166106 chr5:148447061 T/C cg18129178 chr5:148520854 ABLIM3 -0.64 -12.5 -0.44 3.06e-32 Breast cancer; BRCA cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7904368 0.659 rs3740169 chr10:16873547 C/T cg14835575 chr10:16859367 RSU1 0.41 10.04 0.37 3.95e-22 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg24558204 chr6:135376177 HBS1L 0.59 15.94 0.53 1.98e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg18132916 chr6:79620363 NA -0.48 -10.78 -0.39 5.12e-25 Intelligence (multi-trait analysis); BRCA cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg14844989 chr11:31128820 NA -0.44 -9.45 -0.35 6.13e-20 Red blood cell count; BRCA trans rs11098499 0.954 rs11722872 chr4:120233030 G/C cg25214090 chr10:38739885 LOC399744 0.52 11.58 0.42 2.68e-28 Corneal astigmatism; BRCA cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg01475377 chr6:109611718 NA -0.57 -15.31 -0.52 2.73e-45 Reticulocyte fraction of red cells; BRCA cis rs1506636 1.000 rs2896332 chr7:123297223 A/T cg03229431 chr7:123269106 ASB15 -0.64 -14.3 -0.49 1.95e-40 Plateletcrit;Platelet count; BRCA cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg18132916 chr6:79620363 NA -0.48 -10.85 -0.39 2.86e-25 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg03433033 chr1:76189801 ACADM 0.68 13.8 0.48 4.24e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6456156 0.586 rs720325 chr6:167467349 G/T cg07741184 chr6:167504864 NA 0.3 8.84 0.33 9.56e-18 Primary biliary cholangitis; BRCA cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg21782813 chr7:2030301 MAD1L1 -0.29 -8.25 -0.31 9.28e-16 Schizophrenia; BRCA cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg01849466 chr14:104193079 ZFYVE21 0.56 14.74 0.5 1.57e-42 Schizophrenia; BRCA trans rs11722228 1.000 rs6825187 chr4:9915325 T/C cg26043149 chr18:55253948 FECH -0.6 -13.0 -0.46 1.81e-34 Gout;Urate levels;Serum uric acid levels; BRCA cis rs17604090 0.938 rs28457783 chr7:29687058 T/G cg19413766 chr7:29689036 LOC646762 -0.59 -8.17 -0.31 1.67e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg16414030 chr3:133502952 NA -0.47 -11.0 -0.4 7.11e-26 Iron status biomarkers; BRCA trans rs6598955 0.671 rs12145403 chr1:26597189 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -15.17 -0.51 1.22e-44 Obesity-related traits; BRCA cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg20302533 chr7:39170763 POU6F2 0.37 7.83 0.3 2.08e-14 IgG glycosylation; BRCA cis rs6543140 0.964 rs11886793 chr2:103072220 T/G cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs611744 0.647 rs1584373 chr8:109263399 C/A cg21045802 chr8:109455806 TTC35 0.34 7.87 0.3 1.52e-14 Dupuytren's disease; BRCA cis rs9318086 0.624 rs9510909 chr13:24436760 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.33 9.43 0.35 7.59e-20 Myopia (pathological); BRCA cis rs698833 0.828 rs2165421 chr2:44526010 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.29 0.38 4.31e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg16145915 chr7:1198662 ZFAND2A -0.41 -9.19 -0.34 5.3e-19 Longevity;Endometriosis; BRCA cis rs701145 0.537 rs377565 chr3:153921953 A/G cg17054900 chr3:154042577 DHX36 0.42 8.05 0.3 3.99e-15 Coronary artery disease; BRCA cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg23788917 chr6:8435910 SLC35B3 -0.47 -10.25 -0.38 6.36e-23 Motion sickness; BRCA cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg20701182 chr2:24300061 SF3B14 0.71 13.49 0.47 1.15e-36 Lymphocyte counts; BRCA cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg17063962 chr7:91808500 NA -0.54 -12.82 -0.45 1.26e-33 Breast cancer; BRCA cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg01283332 chr5:1856932 NA -0.33 -8.24 -0.31 1.01e-15 Cardiovascular disease risk factors; BRCA cis rs3820928 0.967 rs16822905 chr2:227770727 G/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.77e-16 Pulmonary function; BRCA cis rs11969893 0.850 rs9791284 chr6:101353886 G/A cg12253828 chr6:101329408 ASCC3 1.02 12.24 0.44 4.43e-31 Economic and political preferences (immigration/crime); BRCA cis rs9790314 1.000 rs2218803 chr3:161047973 T/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.04 -0.49 3.35e-39 Morning vs. evening chronotype; BRCA cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg24675658 chr1:53192096 ZYG11B 0.63 15.25 0.52 5.13e-45 Monocyte count; BRCA cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg04607235 chr12:12878440 APOLD1 -0.69 -10.73 -0.39 8.18e-25 Systemic lupus erythematosus; BRCA cis rs61990749 0.597 rs176943 chr14:78175797 T/G cg02301378 chr14:78227641 SNW1;C14orf178 -0.62 -9.5 -0.35 4.3e-20 Fibroblast growth factor basic levels; BRCA cis rs4803468 0.967 rs67047091 chr19:41938684 C/T cg09537434 chr19:41945824 ATP5SL 1.02 23.92 0.69 8.77e-91 Height; BRCA cis rs4948102 0.690 rs35844144 chr7:56050525 C/T cg09872392 chr7:56161020 PHKG1 -0.37 -8.75 -0.33 1.85e-17 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7605378 1.000 rs7605378 chr2:200676926 A/C cg23649088 chr2:200775458 C2orf69 0.49 9.98 0.37 7.05e-22 Osteoporosis; BRCA cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg07606381 chr6:8435919 SLC35B3 0.64 13.98 0.48 5.79e-39 Motion sickness; BRCA cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.41 -0.52 9.02e-46 Systemic lupus erythematosus; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg19626725 chr5:178986131 RUFY1 0.33 9.31 0.35 2.05e-19 Lung cancer; BRCA cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg25019033 chr10:957182 NA -0.42 -8.03 -0.3 4.66e-15 Eosinophil percentage of granulocytes; BRCA cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg05025164 chr4:1340916 KIAA1530 -0.76 -15.52 -0.52 2.34e-46 Longevity; BRCA cis rs2070488 0.761 rs6807940 chr3:38460062 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.62 16.13 0.54 2.36e-49 Electrocardiographic conduction measures; BRCA cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs3960554 1.000 rs2079477 chr7:75836549 C/G cg19862616 chr7:65841803 NCRNA00174 0.57 12.26 0.44 3.4e-31 Eotaxin levels; BRCA cis rs7666738 0.515 rs13118898 chr4:98792893 T/A cg05340658 chr4:99064831 C4orf37 0.55 10.76 0.39 6.32e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg06618935 chr21:46677482 NA -0.36 -8.0 -0.3 5.95e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg08999081 chr20:33150536 PIGU -0.3 -7.82 -0.3 2.25e-14 Height; BRCA cis rs10046574 0.764 rs10269360 chr7:135147425 A/C cg27474649 chr7:135195673 CNOT4 0.56 8.09 0.3 2.99e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6138458 0.962 rs6036976 chr20:24901567 T/G cg26195577 chr20:24973756 C20orf3 -0.98 -24.76 -0.7 2.17e-95 Blood protein levels; BRCA cis rs7267979 1.000 rs6050565 chr20:25347563 A/C cg08601574 chr20:25228251 PYGB -0.33 -7.99 -0.3 6.45e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg06484146 chr7:12443880 VWDE -0.76 -10.67 -0.39 1.43e-24 Coronary artery disease; BRCA trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg17470723 chr8:74884337 TCEB1 0.4 8.67 0.32 3.48e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.6 -10.42 -0.38 1.37e-23 Body mass index (adult); BRCA cis rs3820928 0.904 rs59135978 chr2:227857763 T/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.43 -0.32 2.35e-16 Pulmonary function; BRCA cis rs2742234 0.504 rs10899780 chr10:43725796 T/C cg15436174 chr10:43711423 RASGEF1A 0.54 10.68 0.39 1.35e-24 Hirschsprung disease; BRCA cis rs34779708 0.966 rs2126984 chr10:35410291 A/G cg03585969 chr10:35415529 CREM 0.45 9.44 0.35 6.64e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2762353 0.935 rs1177442 chr6:25809069 A/G cg03264133 chr6:25882463 NA -0.49 -11.09 -0.4 3.07e-26 Blood metabolite levels; BRCA cis rs909002 0.811 rs11575883 chr1:32085485 G/A cg11573219 chr1:32083031 HCRTR1 0.26 8.25 0.31 9.21e-16 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.28 0.56 3.38e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs831571 0.519 rs13059603 chr3:63827381 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.69 13.89 0.48 1.6e-38 Type 2 diabetes; BRCA cis rs6430585 1.000 rs6732236 chr2:136501509 T/G cg07169764 chr2:136633963 MCM6 0.99 19.85 0.62 1.12e-68 Corneal structure; BRCA cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 20.24 0.62 9.74e-71 Platelet count; BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg14403583 chr14:105418241 AHNAK2 -0.4 -9.32 -0.35 1.86e-19 Rheumatoid arthritis; BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.35 -0.41 2.51e-27 Gut microbiome composition (summer); BRCA cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg23262073 chr20:60523788 NA 0.43 9.39 0.35 1.06e-19 Body mass index; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg04944784 chr2:26401820 FAM59B 0.95 16.64 0.55 6.56e-52 Gut microbiome composition (summer); BRCA trans rs561341 1.000 rs564714 chr17:30318404 C/T cg27661571 chr11:113659931 NA -0.81 -12.13 -0.43 1.25e-30 Hip circumference adjusted for BMI; BRCA cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg12373951 chr3:133503437 NA 0.34 8.11 0.31 2.68e-15 Iron status biomarkers; BRCA cis rs17253792 0.822 rs78429067 chr14:56092551 G/A cg01858014 chr14:56050164 KTN1 -0.74 -9.19 -0.34 5.63e-19 Putamen volume; BRCA cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg10802521 chr3:52805072 NEK4 -0.34 -9.2 -0.34 5.17e-19 Bipolar disorder; BRCA cis rs813218 0.523 rs1708167 chr3:99459236 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -9.22 -0.34 4.26e-19 Orofacial clefts; BRCA cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 6.05e-35 Bone mineral density; BRCA cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg09184832 chr6:79620586 NA -0.51 -11.12 -0.4 2.32e-26 Intelligence (multi-trait analysis); BRCA cis rs4566357 0.576 rs10187255 chr2:227913442 T/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.44 -0.35 6.61e-20 Coronary artery disease; BRCA cis rs9287719 0.967 rs6432112 chr2:10744874 A/G cg02196655 chr2:10830764 NOL10 0.29 7.82 0.3 2.13e-14 Prostate cancer; BRCA cis rs3820928 1.000 rs11692572 chr2:227774503 C/G cg11843606 chr2:227700838 RHBDD1 -0.4 -8.87 -0.33 7.08e-18 Pulmonary function; BRCA cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg16325326 chr1:53192061 ZYG11B -0.56 -11.48 -0.41 7.53e-28 Monocyte count; BRCA cis rs847649 0.731 rs10808120 chr7:102672234 A/G cg18108683 chr7:102477205 FBXL13 -0.35 -7.81 -0.3 2.33e-14 Morning vs. evening chronotype; BRCA cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg26384229 chr12:38710491 ALG10B 0.74 16.83 0.55 6.77e-53 Bladder cancer; BRCA cis rs6598955 0.627 rs3924324 chr1:26616280 G/A cg04990556 chr1:26633338 UBXN11 0.53 8.53 0.32 1.04e-16 Obesity-related traits; BRCA cis rs11971779 0.616 rs2883772 chr7:139072756 T/C cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg10523679 chr1:76189770 ACADM -0.47 -9.19 -0.34 5.54e-19 Daytime sleep phenotypes; BRCA cis rs9858542 0.951 rs1800668 chr3:49395757 G/A cg03060546 chr3:49711283 APEH -0.48 -9.56 -0.35 2.39e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7809615 0.901 rs17161761 chr7:99156934 C/T cg12290671 chr7:99195819 NA -0.5 -8.44 -0.32 2.2e-16 Blood metabolite ratios; BRCA cis rs250677 0.687 rs250663 chr5:148453117 T/C cg18129178 chr5:148520854 ABLIM3 -0.6 -12.16 -0.43 9.46e-31 Breast cancer; BRCA cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg05347473 chr6:146136440 FBXO30 -0.44 -8.74 -0.33 2.08e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg05527609 chr1:210001259 C1orf107 -0.78 -16.55 -0.55 1.91e-51 Orofacial clefts; BRCA cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg01028140 chr2:1542097 TPO 0.76 15.07 0.51 3.88e-44 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1401999 1.000 rs4148571 chr3:183720576 A/C cg20387954 chr3:183756860 HTR3D 0.45 10.16 0.37 1.44e-22 Anterior chamber depth; BRCA cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.75 15.37 0.52 1.35e-45 Smoking behavior; BRCA cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs4363385 0.654 rs1129654 chr1:152958238 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.93e-16 Inflammatory skin disease; BRCA cis rs1865760 0.963 rs3846838 chr6:25911775 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.27 0.41 5.3e-27 Height; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.61 11.77 0.42 4.22e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg20701182 chr2:24300061 SF3B14 0.71 12.98 0.46 2.33e-34 Lymphocyte counts; BRCA cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg21664854 chr7:1097933 C7orf50;GPR146 0.52 10.26 0.38 5.84e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs10197940 0.578 rs2432946 chr2:152306897 G/T cg06191203 chr2:152266755 RIF1 0.28 8.23 0.31 1.05e-15 Lung cancer; BRCA cis rs34779708 0.931 rs12248333 chr10:35362977 A/G cg03585969 chr10:35415529 CREM 0.46 9.56 0.35 2.43e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1348850 0.768 rs57681892 chr2:178357645 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 8.52 0.32 1.17e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17253792 0.822 rs111467375 chr14:56046159 T/G cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.29e-20 Putamen volume; BRCA cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg02012338 chr4:187126139 CYP4V2 0.78 8.82 0.33 1.07e-17 Activated partial thromboplastin time; BRCA trans rs6089829 0.962 rs6089825 chr20:61668447 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.33 0.31 4.87e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.7 -0.33 2.74e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7267979 1.000 rs2258617 chr20:25274318 C/T cg08601574 chr20:25228251 PYGB 0.35 8.48 0.32 1.52e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9487023 1 rs9487023 chr6:109590004 A/G cg21918786 chr6:109611834 NA -0.44 -11.7 -0.42 8.55e-29 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; BRCA cis rs4727443 0.866 rs12531809 chr7:99620473 G/T cg22004693 chr7:99632812 ZKSCAN1 0.41 9.12 0.34 9.84e-19 Interstitial lung disease; BRCA trans rs35110281 0.744 rs230646 chr21:44918788 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.2 0.31 1.29e-15 Mean corpuscular volume; BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg02951883 chr7:2050386 MAD1L1 0.45 10.54 0.38 4.67e-24 Bipolar disorder and schizophrenia; BRCA cis rs9291683 0.588 rs3796842 chr4:9995851 A/T cg02734326 chr4:10020555 SLC2A9 0.37 8.42 0.32 2.43e-16 Bone mineral density; BRCA cis rs9467773 0.620 rs2451711 chr6:26663110 A/G cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA trans rs6560039 1 rs6560039 chr9:90474946 C/T cg24436365 chr6:63940138 NA 0.66 17.05 0.56 5.3e-54 Gait variability; BRCA cis rs4812048 0.649 rs6070702 chr20:57621562 G/C cg14073986 chr20:57617431 SLMO2 0.78 12.14 0.43 1.17e-30 Mean platelet volume; BRCA cis rs3008870 0.959 rs2985810 chr1:67376162 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.49 0.65 1.55e-77 Lymphocyte percentage of white cells; BRCA cis rs61524473 1 rs61524473 chr15:45646283 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Metabolite levels (small molecules and protein measures); BRCA cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg13010199 chr12:38710504 ALG10B -0.39 -8.83 -0.33 1.04e-17 Morning vs. evening chronotype; BRCA cis rs7103648 0.630 rs7120548 chr11:47662932 A/G cg03711944 chr11:47377212 SPI1 -0.39 -9.42 -0.35 7.84e-20 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9287719 0.935 rs61424402 chr2:10758371 T/A cg00105475 chr2:10696890 NA 0.44 10.3 0.38 4.08e-23 Prostate cancer; BRCA cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg04756594 chr16:24857601 SLC5A11 0.45 9.52 0.35 3.53e-20 Intelligence (multi-trait analysis); BRCA cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.31 8.12 0.31 2.36e-15 Monocyte percentage of white cells; BRCA trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg25206134 chr2:45395956 NA 0.54 8.8 0.33 1.31e-17 Bipolar disorder; BRCA cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.41e-22 Bladder cancer; BRCA cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.74 -11.52 -0.41 4.85e-28 Mean platelet volume; BRCA cis rs7524258 0.903 rs4908608 chr1:7292772 T/C cg07173049 chr1:7289937 CAMTA1 0.55 13.39 0.47 3.18e-36 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.24 0.31 9.55e-16 Cognitive ability; BRCA cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg00409905 chr10:38381863 ZNF37A 0.44 9.13 0.34 8.87e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg15112475 chr7:1198522 ZFAND2A -0.43 -8.29 -0.31 6.84e-16 Bronchopulmonary dysplasia; BRCA cis rs113835537 0.529 rs4542420 chr11:66277610 G/C cg24851651 chr11:66362959 CCS 0.44 8.3 0.31 6.33e-16 Airway imaging phenotypes; BRCA cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg14343924 chr8:8086146 FLJ10661 0.45 9.31 0.35 2e-19 Systolic blood pressure; BRCA cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg15595755 chr5:1867978 NA 0.36 8.49 0.32 1.45e-16 Cardiovascular disease risk factors; BRCA cis rs17641971 0.899 rs818557 chr8:49984515 G/C cg00325661 chr8:49890786 NA -0.31 -8.18 -0.31 1.52e-15 Blood metabolite levels; BRCA trans rs2204008 0.749 rs10880692 chr12:38592918 C/G cg06521331 chr12:34319734 NA 0.5 9.02 0.34 2.25e-18 Bladder cancer; BRCA cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg17892150 chr10:133769511 PPP2R2D -0.69 -13.81 -0.48 3.74e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 4e-22 Alzheimer's disease; BRCA cis rs6942407 0.546 rs3789251 chr7:86793303 A/G cg02420886 chr7:86849541 C7orf23 0.52 7.81 0.3 2.31e-14 Food allergy; BRCA cis rs1372520 0.684 rs1811442 chr4:90747751 C/T cg15133208 chr4:90757351 SNCA -0.39 -8.06 -0.3 3.72e-15 Neuroticism; BRCA trans rs6582630 0.502 rs11520234 chr12:38255005 G/A cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs6545883 0.929 rs6545873 chr2:61733012 T/C cg15711740 chr2:61764176 XPO1 -0.54 -14.02 -0.49 3.95e-39 Tuberculosis; BRCA cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg17063962 chr7:91808500 NA 0.57 13.25 0.46 1.42e-35 Breast cancer; BRCA cis rs10751667 0.560 rs10902265 chr11:1003642 G/A ch.11.42038R chr11:967971 AP2A2 0.46 13.79 0.48 4.71e-38 Alzheimer's disease (late onset); BRCA trans rs17685 0.753 rs6465000 chr7:75787417 G/A cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.18 -0.34 5.78e-19 Extrinsic epigenetic age acceleration; BRCA cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg20203395 chr5:56204925 C5orf35 -0.45 -8.73 -0.33 2.27e-17 Initial pursuit acceleration; BRCA cis rs875971 0.571 rs160647 chr7:65554352 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.32 -0.38 3.36e-23 Aortic root size; BRCA cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 10.2 0.37 1.01e-22 Aortic root size; BRCA trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg15704280 chr7:45808275 SEPT13 0.78 18.4 0.59 5.58e-61 Coronary artery disease; BRCA cis rs701145 0.585 rs1358405 chr3:153810992 A/G cg17054900 chr3:154042577 DHX36 0.53 8.92 0.33 4.83e-18 Coronary artery disease; BRCA cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg20307385 chr11:47447363 PSMC3 -0.43 -9.03 -0.34 1.96e-18 Subjective well-being; BRCA cis rs17818399 0.547 rs4952833 chr2:46762034 T/C cg02822958 chr2:46747628 ATP6V1E2 0.63 11.49 0.41 6.86e-28 Height; BRCA cis rs477692 0.699 rs509017 chr10:131367174 T/G cg24747557 chr10:131355152 MGMT -0.36 -8.68 -0.32 3.27e-17 Response to temozolomide; BRCA cis rs9467773 0.620 rs9461276 chr6:26595168 T/C cg09904177 chr6:26538194 HMGN4 0.47 15.01 0.51 7.99e-44 Intelligence (multi-trait analysis); BRCA cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg08603382 chr10:743973 NA -0.46 -8.78 -0.33 1.52e-17 Psychosis in Alzheimer's disease; BRCA cis rs1018836 0.884 rs9643307 chr8:91625257 A/C cg16814680 chr8:91681699 NA -0.59 -12.7 -0.45 4.08e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.517 rs4104182 chr12:34081343 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.36 0.49 1.04e-40 Morning vs. evening chronotype; BRCA cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg07741184 chr6:167504864 NA 0.27 7.94 0.3 9.36e-15 Crohn's disease; BRCA cis rs7568458 0.846 rs6738645 chr2:85783128 T/G cg17127132 chr2:85788382 GGCX 0.35 7.97 0.3 7.48e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs68170813 0.559 rs10953534 chr7:106913718 A/G cg02696742 chr7:106810147 HBP1 0.54 8.79 0.33 1.41e-17 Coronary artery disease; BRCA cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg18876405 chr7:65276391 NA -0.63 -15.65 -0.53 5.63e-47 Aortic root size; BRCA cis rs782590 0.967 rs58003472 chr2:55797507 T/C cg18811423 chr2:55921094 PNPT1 0.71 23.03 0.67 6.31e-86 Metabolic syndrome; BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs910316 0.763 rs175047 chr14:75479039 C/G cg11812906 chr14:75593930 NEK9 -0.64 -14.88 -0.51 3.09e-43 Height; BRCA cis rs4803468 1.000 rs284658 chr19:41929988 G/A cg09537434 chr19:41945824 ATP5SL -1.01 -24.77 -0.7 1.88e-95 Height; BRCA cis rs17401966 0.540 rs1467653 chr1:10413123 A/G cg03954927 chr1:10346856 KIF1B -0.33 -9.75 -0.36 4.74e-21 Hepatocellular carcinoma; BRCA cis rs7523273 0.606 rs12401619 chr1:207976276 G/C cg22525895 chr1:207977042 MIR29B2 -0.53 -13.56 -0.47 5.43e-37 Schizophrenia; BRCA cis rs68170813 0.559 rs11769527 chr7:106912948 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.67 -0.32 3.43e-17 Coronary artery disease; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg00420348 chr11:830190 EFCAB4A -0.5 -10.71 -0.39 1.01e-24 Mean platelet volume; BRCA cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg23711669 chr6:146136114 FBXO30 0.72 16.79 0.55 1.07e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs9462027 0.628 rs6906759 chr6:34742990 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.0 -0.3 5.77e-15 Systemic lupus erythematosus; BRCA cis rs9308433 0.529 rs10465696 chr1:214499883 G/A cg06198575 chr1:214491504 SMYD2 0.55 12.1 0.43 1.65e-30 IgG glycosylation; BRCA cis rs243505 0.559 rs2072407 chr7:148508833 A/G cg09806900 chr7:148480153 CUL1 0.52 10.73 0.39 7.94e-25 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg04117972 chr1:227635322 NA -0.46 -8.39 -0.31 3.13e-16 Major depressive disorder; BRCA cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs526821 0.595 rs532278 chr11:55344983 A/G cg15704280 chr7:45808275 SEPT13 -0.42 -7.86 -0.3 1.64e-14 Pediatric bone mineral density (spine); BRCA cis rs2760061 0.626 rs592736 chr1:228116831 A/G cg02753203 chr1:228287806 NA -0.55 -11.81 -0.42 3.02e-29 Diastolic blood pressure; BRCA cis rs6121246 0.909 rs6058463 chr20:30385192 C/T cg21427119 chr20:30132790 HM13 -0.42 -8.88 -0.33 6.48e-18 Mean corpuscular hemoglobin; BRCA cis rs16958440 1.000 rs4609941 chr18:44645491 T/C cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs2404602 0.647 rs12903331 chr15:77168268 C/G cg23625390 chr15:77176239 SCAPER -0.54 -13.79 -0.48 4.61e-38 Blood metabolite levels; BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg08888203 chr3:10149979 C3orf24 0.54 10.05 0.37 3.55e-22 Alzheimer's disease; BRCA cis rs4561483 0.673 rs28279 chr16:11968555 A/C cg08843971 chr16:11963173 GSPT1 0.49 11.07 0.4 3.43e-26 Testicular germ cell tumor; BRCA cis rs17685 0.753 rs10245584 chr7:75745866 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.72 -0.33 2.42e-17 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs6479891 1.000 rs7916282 chr10:65031811 A/T cg14819942 chr15:35414228 NA -0.35 -8.57 -0.32 7.85e-17 Arthritis (juvenile idiopathic); BRCA cis rs460214 0.576 rs28446127 chr21:40029568 C/A cg21578987 chr21:40029669 ERG 0.38 8.78 0.33 1.53e-17 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 11.94 0.43 8.68e-30 Rheumatoid arthritis; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg16606324 chr3:10149918 C3orf24 0.56 11.15 0.4 1.74e-26 Alzheimer's disease; BRCA cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg01206211 chr2:36825736 FEZ2 0.46 10.86 0.39 2.58e-25 Height; BRCA cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg10523679 chr1:76189770 ACADM 0.68 12.55 0.44 1.96e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.72e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17095355 1.000 rs12570423 chr10:111690942 C/T cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.63 -0.36 1.35e-20 Biliary atresia; BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.24 0.44 4.32e-31 Platelet count; BRCA cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg23711669 chr6:146136114 FBXO30 0.74 17.77 0.58 1.06e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg10876282 chr6:28092338 ZSCAN16 0.41 8.16 0.31 1.79e-15 Cardiac Troponin-T levels; BRCA cis rs7512552 0.839 rs1103115 chr1:150332304 G/A cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.81e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs427394 0.582 rs274665 chr5:6707981 C/T cg10857441 chr5:6722123 POLS -0.3 -9.47 -0.35 5.28e-20 Menopause (age at onset); BRCA cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg08917208 chr2:24149416 ATAD2B 0.51 7.96 0.3 7.95e-15 Lymphocyte counts; BRCA cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.87 0.51 3.77e-43 Colorectal cancer; BRCA cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg08645402 chr16:4508243 NA -0.41 -9.55 -0.35 2.69e-20 Schizophrenia; BRCA cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg09359103 chr1:154839909 KCNN3 -0.58 -15.36 -0.52 1.47e-45 Prostate cancer; BRCA cis rs10931896 0.531 rs295118 chr2:201144004 C/T cg23649088 chr2:200775458 C2orf69 0.44 9.53 0.35 3.3e-20 Systolic blood pressure; BRCA cis rs6121246 0.865 rs6089055 chr20:30324045 C/T cg13852791 chr20:30311386 BCL2L1 0.75 12.25 0.44 3.94e-31 Mean corpuscular hemoglobin; BRCA cis rs8005677 0.962 rs10130756 chr14:23396600 C/G cg01529538 chr14:23388837 RBM23 0.42 11.46 0.41 8.38e-28 Cognitive ability (multi-trait analysis); BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg05793240 chr7:2802953 GNA12 -0.33 -8.45 -0.32 2.01e-16 Height; BRCA cis rs34779708 0.931 rs2490663 chr10:35329735 A/G cg03585969 chr10:35415529 CREM -0.45 -9.53 -0.35 3.34e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17092148 0.945 rs6058115 chr20:33358397 T/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.6 0.39 2.74e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -14.01 -0.48 4.39e-39 Platelet count; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg04944784 chr2:26401820 FAM59B -0.95 -16.58 -0.55 1.26e-51 Gut microbiome composition (summer); BRCA cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.67 14.95 0.51 1.43e-43 Hip circumference adjusted for BMI; BRCA trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.62 0.47 2.98e-37 Morning vs. evening chronotype; BRCA cis rs9467773 0.596 rs2494693 chr6:26619226 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.11e-42 Intelligence (multi-trait analysis); BRCA cis rs1401999 0.690 rs1402001 chr3:183642751 A/G cg01324343 chr3:183735012 ABCC5 0.63 15.03 0.51 6.31e-44 Anterior chamber depth; BRCA cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg04450456 chr4:17643702 FAM184B 0.38 11.29 0.41 4.51e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.44 0.68 3.67e-88 Platelet count; BRCA cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg06108461 chr20:60628389 TAF4 -1.01 -23.05 -0.67 5.07e-86 Body mass index; BRCA cis rs67460515 0.892 rs6780536 chr3:161058726 T/C cg03342759 chr3:160939853 NMD3 -0.78 -18.39 -0.59 6.32e-61 Parkinson's disease; BRCA cis rs9814567 1.000 rs13089966 chr3:134279197 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10782582 0.609 rs5745545 chr1:76377356 A/G cg03433033 chr1:76189801 ACADM -0.39 -7.94 -0.3 8.9e-15 Daytime sleep phenotypes; BRCA cis rs7851660 0.967 rs3758251 chr9:100613700 G/C cg13688889 chr9:100608707 NA -0.36 -8.71 -0.33 2.56e-17 Strep throat; BRCA cis rs870825 0.616 rs12512839 chr4:185610347 G/A cg04058563 chr4:185651563 MLF1IP 0.86 16.13 0.54 2.46e-49 Blood protein levels; BRCA cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg07636037 chr3:49044803 WDR6 0.98 29.34 0.76 1.7e-120 Parkinson's disease; BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26314531 chr2:26401878 FAM59B 0.75 10.66 0.39 1.59e-24 Gut microbiome composition (summer); BRCA cis rs12681288 0.823 rs2701908 chr8:1003250 T/C cg04851639 chr8:1020857 NA -0.35 -10.33 -0.38 3.07e-23 Schizophrenia; BRCA cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg26384229 chr12:38710491 ALG10B 0.67 18.57 0.59 6.75e-62 Morning vs. evening chronotype; BRCA cis rs9473147 0.503 rs9473123 chr6:47475339 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.57 0.35 2.33e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg23719950 chr11:63933701 MACROD1 -0.52 -8.56 -0.32 8.52e-17 Mean platelet volume; BRCA cis rs35306767 0.668 rs72760914 chr10:1070952 A/G cg26597838 chr10:835615 NA 0.66 11.09 0.4 3.02e-26 Eosinophil percentage of granulocytes; BRCA cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg04450456 chr4:17643702 FAM184B 0.39 11.66 0.42 1.3e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs829883 0.872 rs1641637 chr12:98890564 G/A cg25150519 chr12:98850993 NA 0.59 11.88 0.43 1.52e-29 Colorectal adenoma (advanced); BRCA cis rs12545109 0.800 rs1467126 chr8:57418452 C/T cg09654669 chr8:57350985 NA -0.39 -8.74 -0.33 2.11e-17 Obesity-related traits; BRCA cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg11833968 chr6:79620685 NA -0.44 -9.81 -0.36 2.92e-21 Intelligence (multi-trait analysis); BRCA trans rs3780486 0.629 rs10971439 chr9:33180813 C/T cg04842962 chr6:43655489 MRPS18A -0.88 -14.68 -0.5 2.84e-42 IgG glycosylation; BRCA cis rs861020 1.000 rs12134698 chr1:209987801 C/A cg05527609 chr1:210001259 C1orf107 -0.7 -15.02 -0.51 6.67e-44 Orofacial clefts; BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.74 -12.85 -0.45 9.13e-34 Platelet count; BRCA cis rs6088813 1.000 rs6142369 chr20:33973315 T/G cg14752227 chr20:34000481 UQCC -0.43 -9.12 -0.34 9.99e-19 Height; BRCA trans rs208520 0.526 rs7775830 chr6:66755249 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.02 30.59 0.77 3.06e-127 Exhaled nitric oxide output; BRCA trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.93 0.3 9.71e-15 Corneal astigmatism; BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -8.23 -0.31 1.08e-15 Total body bone mineral density; BRCA cis rs8180040 0.654 rs62246451 chr3:47211632 C/T cg27129171 chr3:47204927 SETD2 -0.72 -17.49 -0.57 2.94e-56 Colorectal cancer; BRCA cis rs2404602 0.622 rs11637296 chr15:77207885 C/A cg23625390 chr15:77176239 SCAPER -0.53 -12.24 -0.44 4.09e-31 Blood metabolite levels; BRCA cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg06092702 chr1:163392909 NA -0.33 -8.71 -0.33 2.69e-17 Motion sickness; BRCA cis rs534126 0.778 rs10256011 chr7:142936243 G/A cg15652212 chr7:142981776 TMEM139 0.46 10.34 0.38 2.81e-23 Cancer; BRCA cis rs36051895 0.695 rs7045000 chr9:5015143 G/A cg02405213 chr9:5042618 JAK2 -0.45 -8.35 -0.31 4.21e-16 Pediatric autoimmune diseases; BRCA cis rs6782228 0.606 rs7650156 chr3:128361555 T/A cg16766828 chr3:128327626 NA -0.43 -9.67 -0.36 9.7e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg06784218 chr1:46089804 CCDC17 0.49 11.63 0.42 1.71e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3845702 0.736 rs3843323 chr2:180856459 T/C cg01881094 chr2:180872142 CWC22 -1.01 -18.87 -0.6 1.89e-63 Schizophrenia; BRCA cis rs908922 0.676 rs12059256 chr1:152515431 G/A cg20991723 chr1:152506922 NA 0.39 8.95 0.33 3.87e-18 Hair morphology; BRCA cis rs9287719 0.649 rs10929684 chr2:10732224 C/T cg00105475 chr2:10696890 NA -0.42 -9.43 -0.35 7.69e-20 Prostate cancer; BRCA cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11644478 chr21:40555479 PSMG1 0.54 11.62 0.42 1.94e-28 Cognitive function; BRCA cis rs9790314 1.000 rs9790314 chr3:161019558 T/C cg04691961 chr3:161091175 C3orf57 -0.52 -12.94 -0.46 3.68e-34 Morning vs. evening chronotype; BRCA cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg26384229 chr12:38710491 ALG10B 0.87 23.95 0.69 5.8e-91 Heart rate; BRCA cis rs4363385 0.818 rs382292 chr1:153006641 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.57 -0.32 7.61e-17 Inflammatory skin disease; BRCA cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg20203395 chr5:56204925 C5orf35 -0.42 -9.33 -0.35 1.7e-19 Initial pursuit acceleration; BRCA cis rs7904368 0.754 rs12269366 chr10:16850344 G/A cg14835575 chr10:16859367 RSU1 0.62 12.38 0.44 1.07e-31 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs4728302 0.869 rs11770927 chr7:133593126 G/A cg07491979 chr7:133331646 EXOC4 0.36 7.89 0.3 1.31e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.41 0.57 7.61e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.59 0.32 6.82e-17 Glomerular filtration rate (creatinine); BRCA cis rs6570726 0.846 rs7773939 chr6:145927384 C/T cg23711669 chr6:146136114 FBXO30 -0.69 -15.47 -0.52 4.38e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs11718455 1.000 rs1524885 chr3:44031847 G/A cg08738300 chr3:44038990 NA 0.47 8.94 0.33 4.09e-18 Coronary artery disease; BRCA cis rs11098499 0.954 rs17009122 chr4:120362403 G/A cg09307838 chr4:120376055 NA 0.74 15.84 0.53 6.39e-48 Corneal astigmatism; BRCA cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg16405210 chr4:1374714 KIAA1530 -0.37 -8.13 -0.31 2.24e-15 Obesity-related traits; BRCA cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs66887589 0.592 rs2175383 chr4:120215836 C/A cg09307838 chr4:120376055 NA 0.46 9.53 0.35 3.29e-20 Diastolic blood pressure; BRCA cis rs1776421 0.760 rs78493155 chr1:53898195 G/A cg10892335 chr1:53966318 NA 0.5 7.96 0.3 7.83e-15 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs59918340 0.764 rs4961339 chr8:142231504 A/G cg23750338 chr8:142222470 SLC45A4 0.53 12.79 0.45 1.62e-33 Immature fraction of reticulocytes; BRCA cis rs6456156 0.792 rs10946213 chr6:167516095 A/G cg07741184 chr6:167504864 NA -0.3 -8.71 -0.33 2.63e-17 Primary biliary cholangitis; BRCA cis rs6942407 0.546 rs3789252 chr7:86793362 G/C cg02420886 chr7:86849541 C7orf23 0.52 7.81 0.3 2.31e-14 Food allergy; BRCA cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg14863265 chr7:2801509 GNA12 0.39 8.76 0.33 1.74e-17 Height; BRCA cis rs7177699 0.557 rs12442476 chr15:79117856 G/A cg00540400 chr15:79124168 NA 0.27 7.81 0.3 2.44e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs11252926 0.800 rs2209625 chr10:747115 A/C cg08603382 chr10:743973 NA -0.47 -9.92 -0.37 1.1e-21 Psychosis in Alzheimer's disease; BRCA cis rs2281845 0.507 rs7547762 chr1:201088245 A/G cg06714761 chr1:201096289 NA 0.57 14.78 0.5 9.32e-43 Permanent tooth development; BRCA cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg22467129 chr15:76604101 ETFA -0.42 -9.22 -0.34 4.26e-19 Blood metabolite levels; BRCA cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg18876405 chr7:65276391 NA -0.55 -13.19 -0.46 2.51e-35 Aortic root size; BRCA cis rs6542838 0.641 rs4850890 chr2:99535426 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -9.97 -0.37 7.19e-22 Fear of minor pain; BRCA cis rs546131 1.000 rs546131 chr11:34851760 G/C cg11058730 chr11:34937778 PDHX;APIP 0.42 8.05 0.3 4e-15 Lung disease severity in cystic fibrosis; BRCA cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg09184832 chr6:79620586 NA -0.47 -10.26 -0.38 5.98e-23 Intelligence (multi-trait analysis); BRCA cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg02187348 chr16:89574699 SPG7 0.53 13.04 0.46 1.21e-34 Multiple myeloma (IgH translocation); BRCA cis rs17270561 0.609 rs1165156 chr6:25792978 T/C cg16482183 chr6:26056742 HIST1H1C 0.41 8.78 0.33 1.49e-17 Iron status biomarkers; BRCA cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg20701182 chr2:24300061 SF3B14 0.58 9.1 0.34 1.12e-18 Lymphocyte counts; BRCA cis rs9296092 0.538 rs115770720 chr6:33517032 A/T cg13560919 chr6:33536144 NA -0.85 -18.39 -0.59 6.37e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg11584989 chr19:19387371 SF4 0.34 8.94 0.33 4.28e-18 Tonsillectomy; BRCA cis rs870825 0.746 rs1107908 chr4:185620113 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg25036284 chr2:26402008 FAM59B 0.95 16.08 0.54 4.12e-49 Gut microbiome composition (summer); BRCA cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 12.56 0.45 1.65e-32 Personality dimensions; BRCA cis rs4766646 0.619 rs4766637 chr12:110292155 A/C cg01252219 chr12:110302105 GLTP 0.38 8.59 0.32 6.89e-17 Metabolite levels (MHPG); BRCA cis rs11758351 0.660 rs11759904 chr6:26231443 T/C cg01420254 chr6:26195488 NA 0.55 8.52 0.32 1.1e-16 Gout;Renal underexcretion gout; BRCA cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.71 0.39 1.01e-24 Cognitive ability; BRCA cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.94 -0.3 9.04e-15 Ulcerative colitis; BRCA cis rs4363385 0.818 rs2879487 chr1:152985360 C/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.25 -0.34 3.21e-19 Inflammatory skin disease; BRCA cis rs735860 0.726 rs209490 chr6:53179047 C/T cg10236188 chr6:53219634 NA 0.38 7.98 0.3 6.78e-15 Glaucoma; BRCA cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.32e-32 Breast cancer; BRCA cis rs9287719 0.935 rs1309 chr2:10743546 A/G cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs769267 0.931 rs15622 chr19:19468734 G/A cg03709012 chr19:19516395 GATAD2A -0.75 -16.68 -0.55 3.8e-52 Tonsillectomy; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg00814883 chr7:100076585 TSC22D4 -0.51 -11.72 -0.42 7.39e-29 Platelet count; BRCA cis rs4919087 0.923 rs12357266 chr10:98978045 G/A cg25902810 chr10:99078978 FRAT1 0.41 8.59 0.32 6.62e-17 Monocyte count; BRCA cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg23992470 chr4:843637 GAK 0.56 8.31 0.31 5.57e-16 Intelligence (multi-trait analysis); BRCA cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg12935359 chr14:103987150 CKB 0.61 13.49 0.47 1.08e-36 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg21747090 chr2:27597821 SNX17 -0.37 -8.08 -0.3 3.26e-15 Total body bone mineral density; BRCA cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg21856205 chr7:94953877 PON1 -0.37 -8.17 -0.31 1.68e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs35110281 0.811 rs4819264 chr21:45017349 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.39 0.38 1.87e-23 Mean corpuscular volume; BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.73 0.36 5.88e-21 Gut microbiome composition (summer); BRCA cis rs6840360 0.615 rs62329085 chr4:152470237 G/A cg25486957 chr4:152246857 NA -0.36 -7.9 -0.3 1.26e-14 Intelligence (multi-trait analysis); BRCA trans rs6762477 0.748 rs3755831 chr3:50228767 G/T cg21659725 chr3:3221576 CRBN -0.34 -8.23 -0.31 1.07e-15 Menarche (age at onset); BRCA cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.21 0.49 5.09e-40 Motion sickness; BRCA cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs992157 0.835 rs7585702 chr2:219146607 T/C cg00012203 chr2:219082015 ARPC2 -0.47 -9.2 -0.34 4.93e-19 Colorectal cancer; BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA trans rs6582630 0.502 rs11520276 chr12:38359216 C/T cg06521331 chr12:34319734 NA -0.47 -8.55 -0.32 8.91e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg09877947 chr5:131593287 PDLIM4 0.42 9.88 0.36 1.55e-21 Acylcarnitine levels; BRCA cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg26395211 chr5:140044315 WDR55 0.37 8.59 0.32 6.46e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs950169 0.579 rs62027818 chr15:84661145 T/C cg17507749 chr15:85114479 UBE2QP1 0.56 9.07 0.34 1.45e-18 Schizophrenia; BRCA cis rs4363385 0.818 rs382653 chr1:153006761 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.08e-14 Inflammatory skin disease; BRCA cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.55 0.47 6.2e-37 Mean platelet volume; BRCA trans rs4332037 0.624 rs11764124 chr7:1891723 C/G cg25206134 chr2:45395956 NA 0.53 8.97 0.33 3.15e-18 Bipolar disorder; BRCA cis rs2019216 0.903 rs1817415 chr17:21893338 C/G cg22648282 chr17:21454238 C17orf51 -0.35 -8.03 -0.3 4.85e-15 Pelvic organ prolapse; BRCA cis rs11734570 0.581 rs79354477 chr4:38597448 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.53 9.92 0.37 1.11e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg03264133 chr6:25882463 NA -0.76 -18.58 -0.59 6.39e-62 Uric acid levels; BRCA cis rs7474896 0.583 rs10827818 chr10:38000856 T/C cg25427524 chr10:38739819 LOC399744 -0.55 -10.09 -0.37 2.52e-22 Obesity (extreme); BRCA cis rs853679 0.546 rs34295134 chr6:27828151 T/A cg26587870 chr6:27730563 NA -0.54 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -1.06 -18.86 -0.6 1.99e-63 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs113835537 0.597 rs3737525 chr11:66306355 A/G cg24851651 chr11:66362959 CCS 0.53 9.23 0.34 3.81e-19 Airway imaging phenotypes; BRCA cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg16482183 chr6:26056742 HIST1H1C 0.53 11.03 0.4 5.12e-26 Height; BRCA cis rs1864400 0.696 rs2742239 chr10:43621712 A/G cg15436174 chr10:43711423 RASGEF1A -0.53 -10.75 -0.39 6.99e-25 Hirschsprung disease; BRCA trans rs9929218 0.954 rs4485355 chr16:68754730 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -16.17 -0.54 1.52e-49 Colorectal cancer; BRCA cis rs864745 0.690 rs849140 chr7:28183702 T/C cg22892036 chr7:28189139 JAZF1 0.48 10.61 0.39 2.56e-24 Crohn's disease;Type 2 diabetes; BRCA cis rs208520 0.802 rs4710314 chr6:66883656 G/A cg07460842 chr6:66804631 NA -0.95 -17.73 -0.57 1.73e-57 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg17366294 chr4:99064904 C4orf37 -0.41 -9.7 -0.36 7.63e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg04267008 chr7:1944627 MAD1L1 -0.63 -14.77 -0.5 1.12e-42 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -11.59 -0.42 2.62e-28 Platelet count; BRCA cis rs3768617 0.811 rs10797828 chr1:183028430 G/A ch.1.3577855R chr1:183094577 LAMC1 0.45 9.72 0.36 6.38e-21 Fuchs's corneal dystrophy; BRCA cis rs7523273 0.586 rs2796264 chr1:207919968 A/G cg22525895 chr1:207977042 MIR29B2 0.47 12.1 0.43 1.74e-30 Schizophrenia; BRCA cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg11058730 chr11:34937778 PDHX;APIP 0.67 15.53 0.52 2.23e-46 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA trans rs7824557 0.591 rs2736282 chr8:11225480 C/T cg06636001 chr8:8085503 FLJ10661 0.43 8.65 0.32 4e-17 Retinal vascular caliber; BRCA cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg06640241 chr16:89574553 SPG7 0.87 22.48 0.66 6.59e-83 Multiple myeloma (IgH translocation); BRCA cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg25427524 chr10:38739819 LOC399744 0.68 16.57 0.55 1.48e-51 Extrinsic epigenetic age acceleration; BRCA cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg25801113 chr15:45476975 SHF -0.34 -8.33 -0.31 4.87e-16 Uric acid levels; BRCA cis rs9341808 0.754 rs9294173 chr6:80991630 T/A cg08355045 chr6:80787529 NA 0.35 9.11 0.34 1.03e-18 Sitting height ratio; BRCA cis rs13046373 0.535 rs1395778 chr21:31985502 G/C cg22337977 chr21:31811175 KRTAP15-1 0.34 8.01 0.3 5.5e-15 HDL cholesterol; BRCA cis rs7586879 0.752 rs11683748 chr2:25130434 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.5 0.35 4.12e-20 Body mass index; BRCA cis rs6598955 0.671 rs12139514 chr1:26575939 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs2836633 0.895 rs61085980 chr21:40032140 C/T cg05519781 chr21:40033154 ERG 0.37 8.0 0.3 5.68e-15 Coronary artery disease; BRCA cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.42 0.35 8.21e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg22875332 chr1:76189707 ACADM 0.69 14.42 0.5 5.03e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7267979 1.000 rs8125868 chr20:25324410 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.6 -0.32 6.2e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1580019 0.961 rs11765387 chr7:32494790 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.09 0.54 3.59e-49 Cognitive ability; BRCA cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.4 -7.91 -0.3 1.12e-14 Extrinsic epigenetic age acceleration; BRCA cis rs796364 0.806 rs188102 chr2:200903189 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -10.1 -0.37 2.41e-22 Schizophrenia; BRCA cis rs7011049 1.000 rs11985687 chr8:53832602 G/A cg26025543 chr8:53854495 NA 0.55 9.98 0.37 7e-22 Systolic blood pressure; BRCA cis rs1784581 0.802 rs7768986 chr6:162427890 G/C cg17173639 chr6:162384350 PARK2 0.39 9.15 0.34 7.26e-19 Itch intensity from mosquito bite; BRCA trans rs11098499 0.863 rs7669520 chr4:120515278 T/C cg25214090 chr10:38739885 LOC399744 0.52 11.58 0.42 2.83e-28 Corneal astigmatism; BRCA cis rs9790314 0.846 rs9809522 chr3:160983768 G/C cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA trans rs3733585 0.673 rs4235348 chr4:9951968 T/C cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2.06e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg12011299 chr4:100065546 ADH4 0.48 10.79 0.39 4.86e-25 Smoking initiation; BRCA cis rs4077515 0.934 rs3829111 chr9:139269483 G/A cg14019695 chr9:139328340 INPP5E 0.32 8.13 0.31 2.31e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7819412 0.745 rs4841498 chr8:10985432 C/T cg21775007 chr8:11205619 TDH -0.42 -8.69 -0.33 2.94e-17 Triglycerides; BRCA cis rs3916 0.911 rs12829722 chr12:121155622 C/T cg21892295 chr12:121157589 UNC119B -0.35 -8.45 -0.32 1.92e-16 Urinary metabolites (H-NMR features); BRCA cis rs9811920 0.695 rs1287284 chr3:99516962 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -12.87 -0.45 7.38e-34 Axial length; BRCA cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.24 0.49 3.83e-40 Motion sickness; BRCA cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.4e-77 Mean platelet volume; BRCA cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.04 0.43 3.16e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7572733 0.515 rs1518368 chr2:198839145 G/A cg00792783 chr2:198669748 PLCL1 0.45 9.86 0.36 1.98e-21 Dermatomyositis; BRCA cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg23711669 chr6:146136114 FBXO30 0.75 17.42 0.57 6.43e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.95 0.37 8.46e-22 Bipolar disorder; BRCA cis rs858239 0.600 rs7456915 chr7:23143049 T/C cg23682824 chr7:23144976 KLHL7 0.46 12.25 0.44 3.7e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg16322792 chr1:120165303 ZNF697 0.58 15.43 0.52 6.54e-46 Systemic lupus erythematosus; BRCA cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.78 11.05 0.4 4.45e-26 Initial pursuit acceleration; BRCA cis rs1401999 0.650 rs3792585 chr3:183646222 A/G cg20387954 chr3:183756860 HTR3D 0.37 8.6 0.32 5.95e-17 Anterior chamber depth; BRCA cis rs17270561 0.636 rs2070642 chr6:25831212 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 9.33 0.35 1.73e-19 Iron status biomarkers; BRCA cis rs7666738 0.830 rs28622458 chr4:98916651 A/G cg17366294 chr4:99064904 C4orf37 0.41 9.64 0.36 1.28e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg18876405 chr7:65276391 NA 0.56 13.33 0.47 6.11e-36 Aortic root size; BRCA cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg08885076 chr2:99613938 TSGA10 0.46 10.82 0.39 3.68e-25 Chronic sinus infection; BRCA trans rs7824557 0.614 rs2736277 chr8:11218893 C/T cg06636001 chr8:8085503 FLJ10661 -0.41 -8.6 -0.32 6.36e-17 Retinal vascular caliber; BRCA cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.32 0.57 2.11e-55 Bladder cancer; BRCA cis rs7809950 1.000 rs2894475 chr7:107262558 A/T cg23024343 chr7:107201750 COG5 -0.35 -8.03 -0.3 4.74e-15 Coronary artery disease; BRCA trans rs11098499 0.954 rs34858317 chr4:120387110 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs12431939 0.948 rs12436158 chr14:51669891 G/A cg23942311 chr14:51606299 NA -0.43 -8.02 -0.3 5.06e-15 Cancer; BRCA cis rs12711979 0.729 rs6714956 chr2:3820454 T/C cg17052675 chr2:3827356 NA -0.48 -14.09 -0.49 1.93e-39 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg15112475 chr7:1198522 ZFAND2A -0.58 -14.57 -0.5 9.62e-42 Longevity;Endometriosis; BRCA cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg18105134 chr13:113819100 PROZ -0.64 -14.55 -0.5 1.17e-41 Platelet distribution width; BRCA cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg18876405 chr7:65276391 NA 0.61 15.07 0.51 3.77e-44 Aortic root size; BRCA cis rs1506403 0.685 rs1994497 chr7:142816927 A/G cg21852589 chr7:142981689 TMEM139 0.4 7.89 0.3 1.28e-14 Cancer; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg14863265 chr7:2801509 GNA12 0.45 9.88 0.36 1.59e-21 Height; BRCA cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.697 rs10020027 chr4:120381879 G/C cg09307838 chr4:120376055 NA 0.76 17.1 0.56 2.9e-54 Corneal astigmatism; BRCA trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -13.86 -0.48 2.11e-38 Extrinsic epigenetic age acceleration; BRCA cis rs7786877 0.723 rs6969697 chr7:100209604 G/A cg16850897 chr7:100343110 ZAN -0.57 -10.61 -0.39 2.54e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1577917 1.000 rs2324843 chr6:86617501 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -8.71 -0.33 2.62e-17 Response to antipsychotic treatment; BRCA cis rs9463078 0.764 rs9395051 chr6:44825715 C/A cg25276700 chr6:44698697 NA -0.36 -8.3 -0.31 6.41e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg04166393 chr7:2884313 GNA12 0.49 9.05 0.34 1.77e-18 Height; BRCA cis rs10193935 0.901 rs10490552 chr2:42559947 C/T cg27598129 chr2:42591480 NA 0.61 10.55 0.39 4.09e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2985684 0.894 rs6572586 chr14:50021941 A/C cg04989706 chr14:50066350 PPIL5 -0.5 -10.04 -0.37 3.96e-22 Carotid intima media thickness; BRCA cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.72 -0.55 2.49e-52 Breast cancer; BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.05 22.15 0.66 4.01e-81 Gut microbiome composition (summer); BRCA cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg21573476 chr21:45109991 RRP1B -0.36 -9.05 -0.34 1.76e-18 Mean corpuscular volume; BRCA cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.04e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.18 -0.49 7.38e-40 Initial pursuit acceleration; BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 17.69 0.57 2.6e-57 Alzheimer's disease; BRCA cis rs61931739 0.534 rs2625897 chr12:34064295 G/A cg06521331 chr12:34319734 NA -0.62 -12.41 -0.44 8.14e-32 Morning vs. evening chronotype; BRCA cis rs36051895 0.659 rs7045491 chr9:5045658 G/A cg02405213 chr9:5042618 JAK2 -0.5 -9.59 -0.35 1.9e-20 Pediatric autoimmune diseases; BRCA cis rs11626933 1.000 rs2236402 chr14:90734378 C/G cg14092571 chr14:90743983 NA -0.81 -21.02 -0.64 6.16e-75 Gut microbiota (bacterial taxa); BRCA cis rs4077515 0.577 rs3812584 chr9:139312719 C/T cg14019695 chr9:139328340 INPP5E -0.4 -10.65 -0.39 1.69e-24 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2985684 0.846 rs10150624 chr14:50051565 A/G cg04989706 chr14:50066350 PPIL5 -0.47 -9.21 -0.34 4.76e-19 Carotid intima media thickness; BRCA cis rs2645694 0.651 rs2703128 chr4:77819187 C/G cg18351406 chr4:77819688 ANKRD56 0.56 12.4 0.44 8.76e-32 Emphysema distribution in smoking; BRCA cis rs6834538 1.000 rs6823117 chr4:113447354 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.41 9.15 0.34 7.29e-19 Free thyroxine concentration; BRCA trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg22491629 chr6:157744540 C6orf35 -0.68 -12.22 -0.44 5.38e-31 Hemostatic factors and hematological phenotypes; BRCA cis rs61931739 0.517 rs2636074 chr12:34064056 C/T cg06521331 chr12:34319734 NA -0.62 -12.41 -0.44 8.14e-32 Morning vs. evening chronotype; BRCA cis rs17401966 0.540 rs10864452 chr1:10395683 G/T cg03954927 chr1:10346856 KIF1B 0.34 10.41 0.38 1.54e-23 Hepatocellular carcinoma; BRCA cis rs6835098 1.000 rs6826412 chr4:174109622 C/T cg27433088 chr4:174089019 GALNT7 0.34 9.24 0.34 3.48e-19 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs2880765 0.566 rs17553249 chr15:86006694 A/G cg10818794 chr15:86012489 AKAP13 -0.4 -10.79 -0.39 4.89e-25 Coronary artery disease; BRCA cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg08355456 chr11:67383691 NA 0.4 8.42 0.32 2.4e-16 Mean corpuscular volume; BRCA cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg00012203 chr2:219082015 ARPC2 -0.49 -9.47 -0.35 5.19e-20 Colorectal cancer; BRCA cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg08917208 chr2:24149416 ATAD2B 0.53 8.25 0.31 8.81e-16 Asthma; BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.61 -0.39 2.57e-24 Gut microbiome composition (summer); BRCA cis rs2290402 0.536 rs17165130 chr4:875339 A/C cg08937613 chr4:881914 GAK 0.49 8.05 0.3 4.2e-15 Type 2 diabetes; BRCA cis rs9486719 1.000 rs12213426 chr6:96896035 T/C cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.97e-34 Migraine;Coronary artery disease; BRCA cis rs7264396 0.790 rs761825 chr20:34194054 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -13.72 -0.48 1.03e-37 Total cholesterol levels; BRCA cis rs3762637 1.000 rs11932 chr3:122141135 A/G cg24169773 chr3:122142474 KPNA1 0.43 8.21 0.31 1.18e-15 LDL cholesterol levels; BRCA cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg00631329 chr6:26305371 NA -0.44 -13.13 -0.46 5.16e-35 Educational attainment; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg22920501 chr2:26401640 FAM59B -0.89 -16.19 -0.54 1.2e-49 Gut microbiome composition (summer); BRCA cis rs3772130 0.962 rs9812228 chr3:121495682 C/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.68 0.39 1.31e-24 Cognitive performance; BRCA cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg00409905 chr10:38381863 ZNF37A 0.45 9.36 0.35 1.3e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs1577917 0.958 rs4707223 chr6:86509802 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.48 -12.9 -0.45 5.31e-34 Response to antipsychotic treatment; BRCA cis rs701145 0.585 rs6769099 chr3:153852442 T/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.31 -0.35 2.06e-19 Alzheimer's disease (late onset); BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.73 0.42 6.45e-29 Tonsillectomy; BRCA cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg27129171 chr3:47204927 SETD2 0.72 17.71 0.57 2.19e-57 Colorectal cancer; BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg12564285 chr5:131593104 PDLIM4 0.37 9.95 0.37 8.59e-22 Breast cancer; BRCA cis rs6745190 0.575 rs35049898 chr2:181982277 C/T cg00481216 chr2:181971175 NA 0.4 9.38 0.35 1.09e-19 White blood cell count; BRCA cis rs1163251 0.837 rs517533 chr1:120229170 T/G cg19096424 chr1:120255104 PHGDH 0.45 10.28 0.38 4.69e-23 Blood metabolite levels; BRCA cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.22 -0.44 4.98e-31 Personality dimensions; BRCA cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg01191920 chr7:158217561 PTPRN2 -0.46 -11.01 -0.4 6.11e-26 Obesity-related traits; BRCA cis rs3857536 0.642 rs7755840 chr6:66891913 A/G cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.57 0.39 3.43e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.06 -0.4 3.82e-26 Lymphocyte counts; BRCA cis rs7927771 1.000 rs12421210 chr11:47779586 C/T cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs4588572 0.601 rs10942855 chr5:77737529 G/A cg11547950 chr5:77652471 NA -0.45 -8.07 -0.3 3.57e-15 Triglycerides; BRCA cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg24110177 chr3:50126178 RBM5 -0.5 -14.25 -0.49 3.44e-40 Body mass index; BRCA cis rs6429082 0.689 rs10802803 chr1:235709610 A/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -12.59 -0.45 1.31e-32 Adiposity; BRCA cis rs6120849 0.663 rs11698868 chr20:33549946 C/T cg24642439 chr20:33292090 TP53INP2 0.59 10.26 0.38 5.53e-23 Protein C levels; BRCA cis rs10267417 0.603 rs2892957 chr7:19952910 T/A cg05791153 chr7:19748676 TWISTNB 0.42 7.9 0.3 1.2e-14 Night sleep phenotypes; BRCA trans rs11098499 0.697 rs10020027 chr4:120381879 G/C cg25214090 chr10:38739885 LOC399744 0.54 12.59 0.45 1.29e-32 Corneal astigmatism; BRCA cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg10556349 chr10:835070 NA 0.73 9.85 0.36 2.01e-21 Eosinophil percentage of granulocytes; BRCA cis rs6964587 1.000 rs2282974 chr7:91761617 G/A cg01689657 chr7:91764605 CYP51A1 0.23 8.3 0.31 6.06e-16 Breast cancer; BRCA trans rs6951245 0.529 rs76001997 chr7:1152615 C/T cg13565492 chr6:43139072 SRF -0.87 -15.93 -0.53 2.33e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10733682 0.524 rs10987419 chr9:129462594 T/C cg00232160 chr9:129468157 NA 0.35 8.02 0.3 5.09e-15 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21659725 chr3:3221576 CRBN 0.48 12.2 0.43 6.63e-31 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg22920501 chr2:26401640 FAM59B 0.9 16.44 0.55 6.44e-51 Gut microbiome composition (summer); BRCA trans rs877282 0.838 rs34912955 chr10:772222 T/C cg22713356 chr15:30763199 NA 1.31 26.42 0.72 1.54e-104 Uric acid levels; BRCA cis rs798554 0.679 rs798499 chr7:2792013 G/A cg04166393 chr7:2884313 GNA12 0.41 8.7 0.33 2.74e-17 Height; BRCA cis rs11098499 0.908 rs7695996 chr4:120322033 C/T cg09307838 chr4:120376055 NA 0.73 15.87 0.53 4.5e-48 Corneal astigmatism; BRCA trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg22153745 chr1:153894579 GATAD2B -0.49 -9.7 -0.36 7.72e-21 Total cholesterol levels; BRCA cis rs10752881 1.000 rs10752885 chr1:182982878 C/G ch.1.3577855R chr1:183094577 LAMC1 0.64 17.21 0.56 8.31e-55 Colorectal cancer; BRCA cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg08975724 chr8:8085496 FLJ10661 0.5 10.64 0.39 1.9e-24 Mood instability; BRCA cis rs765787 0.530 rs3759893 chr15:45542950 G/T cg15395560 chr15:45543142 SLC28A2 0.29 8.08 0.3 3.2e-15 Uric acid levels; BRCA cis rs11971779 0.590 rs4732374 chr7:139091453 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.36 0.38 2.36e-23 Diisocyanate-induced asthma; BRCA cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg22491629 chr6:157744540 C6orf35 -0.6 -11.7 -0.42 8.34e-29 Hemostatic factors and hematological phenotypes; BRCA trans rs8073060 0.586 rs7208672 chr17:33989759 G/A cg19694781 chr19:47549865 TMEM160 -1.04 -21.1 -0.64 2.24e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.73 -12.7 -0.45 3.91e-33 Platelet count; BRCA cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg23895963 chr12:117471115 NA 0.51 9.18 0.34 6.12e-19 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 17.71 0.57 2.06e-57 Alzheimer's disease; BRCA cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg23711669 chr6:146136114 FBXO30 -0.76 -17.44 -0.57 5.18e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs7607369 0.574 rs12990478 chr2:219667463 T/A cg02176678 chr2:219576539 TTLL4 -0.38 -10.17 -0.37 1.3e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs2880765 0.835 rs7161880 chr15:86018746 C/T cg10818794 chr15:86012489 AKAP13 -0.31 -8.63 -0.32 4.91e-17 Coronary artery disease; BRCA cis rs6684514 1.000 rs12038481 chr1:156284815 T/C cg16558208 chr1:156270281 VHLL 0.36 8.47 0.32 1.73e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.72 0.36 6.47e-21 Bladder cancer; BRCA cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg18876405 chr7:65276391 NA 0.51 11.49 0.41 6.32e-28 Aortic root size; BRCA cis rs739401 0.572 rs404629 chr11:3077025 A/G cg25174290 chr11:3078921 CARS 0.44 12.99 0.46 2.06e-34 Longevity; BRCA cis rs1801251 0.656 rs10211596 chr2:233699415 C/T cg08000102 chr2:233561755 GIGYF2 -0.63 -14.74 -0.5 1.61e-42 Coronary artery disease; BRCA cis rs9790314 0.846 rs13083229 chr3:161008125 G/A cg04691961 chr3:161091175 C3orf57 -0.41 -10.17 -0.37 1.33e-22 Morning vs. evening chronotype; BRCA cis rs72772090 0.710 rs11750400 chr5:96077968 A/T cg24982541 chr5:96078678 CAST -0.46 -8.03 -0.3 4.58e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs1891275 0.515 rs4244930 chr10:93466849 T/C cg07889827 chr10:93443413 NA -0.4 -10.95 -0.4 1.12e-25 Intelligence (multi-trait analysis); BRCA cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg23791538 chr6:167370224 RNASET2 -0.46 -11.48 -0.41 7.26e-28 Crohn's disease; BRCA cis rs495337 0.736 rs568124 chr20:48484125 C/T cg17835207 chr20:48524531 SPATA2 -0.5 -10.58 -0.39 3.21e-24 Psoriasis; BRCA cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg11890956 chr21:40555474 PSMG1 1.06 31.2 0.78 1.58e-130 Cognitive function; BRCA cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg12311346 chr5:56204834 C5orf35 -0.46 -9.23 -0.34 4.04e-19 Coronary artery disease; BRCA cis rs7584330 0.780 rs12474519 chr2:238377012 G/A cg14458575 chr2:238380390 NA 0.5 11.48 0.41 7.3e-28 Prostate cancer; BRCA cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg20503657 chr10:835505 NA 1.3 21.68 0.65 1.61e-78 Eosinophil percentage of granulocytes; BRCA cis rs6570726 0.935 rs12663204 chr6:145818373 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.08 0.51 3.35e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs9462027 0.606 rs7341253 chr6:34726838 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 7.76e-15 Systemic lupus erythematosus; BRCA cis rs1865760 0.892 rs9379806 chr6:25940958 G/A cg16482183 chr6:26056742 HIST1H1C 0.5 10.25 0.38 6.32e-23 Height; BRCA trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.07 -0.56 4.02e-54 Intelligence (multi-trait analysis); BRCA trans rs9291683 0.595 rs11731110 chr4:10037346 T/C cg26043149 chr18:55253948 FECH 0.42 9.08 0.34 1.33e-18 Bone mineral density; BRCA cis rs13161895 1.000 rs4700853 chr5:179473328 G/A cg02702477 chr5:179499311 RNF130 0.46 8.53 0.32 1.03e-16 LDL cholesterol; BRCA cis rs9325144 0.555 rs7301258 chr12:38706942 C/T cg26384229 chr12:38710491 ALG10B 0.5 12.61 0.45 1.05e-32 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs17092148 0.895 rs4417778 chr20:33350987 T/C cg16810054 chr20:33298113 TP53INP2 -0.49 -11.19 -0.4 1.19e-26 Neuroticism; BRCA cis rs13190036 1.000 rs3733875 chr5:176637240 G/T cg06733329 chr5:176740039 MXD3 0.46 8.33 0.31 5.04e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs6032067 0.673 rs991048 chr20:43898227 C/T cg06407657 chr20:43937138 MATN4;RBPJL -0.3 -8.28 -0.31 7.18e-16 Blood protein levels; BRCA cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg22974920 chr21:40686053 BRWD1 -0.39 -8.73 -0.33 2.15e-17 Cognitive function; BRCA cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06022373 chr22:39101656 GTPBP1 0.74 18.2 0.58 5.93e-60 Menopause (age at onset); BRCA cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg05863683 chr7:1912471 MAD1L1 0.42 8.94 0.33 4.25e-18 Schizophrenia; BRCA cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg18016565 chr1:150552671 MCL1 -0.45 -10.16 -0.37 1.39e-22 Tonsillectomy; BRCA cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.63 0.55 7.2e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg17143192 chr8:8559678 CLDN23 -0.54 -10.32 -0.38 3.41e-23 Obesity-related traits; BRCA cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg17691542 chr6:26056736 HIST1H1C 0.75 14.56 0.5 1.06e-41 Iron status biomarkers; BRCA cis rs2050392 0.517 rs619864 chr10:30750950 A/G cg18806716 chr10:30721971 MAP3K8 0.48 11.48 0.41 7.15e-28 Inflammatory bowel disease; BRCA cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg27624424 chr6:160112604 SOD2 0.41 8.79 0.33 1.35e-17 Age-related macular degeneration (geographic atrophy); BRCA cis rs3771570 0.901 rs55764424 chr2:242407467 C/T cg21155796 chr2:242212141 HDLBP 0.55 9.29 0.34 2.4e-19 Prostate cancer; BRCA cis rs4268898 0.552 rs11125444 chr2:24367205 G/T cg26838691 chr2:24397539 C2orf84 0.39 7.96 0.3 8.05e-15 Asthma; BRCA cis rs3087591 0.922 rs2953013 chr17:29496343 A/C cg24425628 chr17:29625626 OMG;NF1 -0.42 -8.27 -0.31 7.97e-16 Hip circumference; BRCA cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg26384229 chr12:38710491 ALG10B 0.69 16.21 0.54 9.67e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.23 0.58 4.19e-60 Platelet count; BRCA cis rs6840360 0.615 rs4696096 chr4:152475387 A/G cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -18.93 -0.6 8.44e-64 Chronic sinus infection; BRCA cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg24642439 chr20:33292090 TP53INP2 -0.54 -11.77 -0.42 4.23e-29 Glomerular filtration rate (creatinine); BRCA cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg16179182 chr5:140090404 VTRNA1-1 0.45 10.65 0.39 1.66e-24 Depressive symptoms (multi-trait analysis); BRCA cis rs752010 0.806 rs11210500 chr1:42089737 A/G cg06885757 chr1:42089581 HIVEP3 0.31 11.08 0.4 3.24e-26 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6750047 0.638 rs336031 chr2:38265130 C/A cg07380506 chr2:38303506 CYP1B1 -0.44 -9.54 -0.35 3.02e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.9 -0.33 5.71e-18 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.19 -0.43 6.98e-31 Alzheimer's disease; BRCA cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg08888203 chr3:10149979 C3orf24 -0.69 -14.67 -0.5 3.13e-42 Alzheimer's disease; BRCA cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg03264133 chr6:25882463 NA -0.52 -10.92 -0.4 1.44e-25 Intelligence (multi-trait analysis); BRCA cis rs7100689 0.646 rs2994390 chr10:82074395 C/A cg01528321 chr10:82214614 TSPAN14 0.78 16.58 0.55 1.23e-51 Post bronchodilator FEV1; BRCA trans rs7786808 0.552 rs4909205 chr7:158185283 G/A cg02030672 chr11:45687055 CHST1 0.46 9.78 0.36 3.82e-21 Obesity-related traits; BRCA trans rs2204008 0.811 rs2139752 chr12:38370398 C/T cg06521331 chr12:34319734 NA -0.46 -8.45 -0.32 1.9e-16 Bladder cancer; BRCA cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg24675658 chr1:53192096 ZYG11B 0.55 12.64 0.45 7.42e-33 Monocyte count; BRCA cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg05347473 chr6:146136440 FBXO30 -0.43 -8.67 -0.32 3.5e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg05729581 chr11:3078854 CARS -0.37 -9.15 -0.34 7.77e-19 Longevity; BRCA cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg21475434 chr5:93447410 FAM172A 0.66 8.66 0.32 3.97e-17 Diabetic retinopathy; BRCA cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg19318889 chr4:1322082 MAEA 0.54 11.25 0.41 6.56e-27 Longevity; BRCA cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24110177 chr3:50126178 RBM5 0.37 9.93 0.37 1.07e-21 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.649 rs2024432 chr2:10731474 C/T cg00105475 chr2:10696890 NA 0.41 9.18 0.34 5.88e-19 Prostate cancer; BRCA trans rs11098499 0.909 rs28581362 chr4:120283548 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg17063962 chr7:91808500 NA 0.54 12.82 0.45 1.26e-33 Breast cancer; BRCA cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg24450063 chr1:156163899 SLC25A44 0.95 18.31 0.59 1.66e-60 Testicular germ cell tumor; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg26608667 chr7:1196370 ZFAND2A -0.39 -8.79 -0.33 1.43e-17 Longevity;Endometriosis; BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.07 0.34 1.47e-18 Tonsillectomy; BRCA cis rs838147 0.815 rs28400015 chr19:49250633 G/A cg13540341 chr19:49222985 MAMSTR 0.32 8.38 0.31 3.35e-16 Dietary macronutrient intake; BRCA cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.26e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg05283184 chr6:79620031 NA -0.43 -10.88 -0.4 2.01e-25 Intelligence (multi-trait analysis); BRCA cis rs698833 0.548 rs1372079 chr2:44543317 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.13 0.31 2.2e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9486719 1.000 rs12191653 chr6:96903898 T/C cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.66e-34 Migraine;Coronary artery disease; BRCA cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg13319975 chr6:146136371 FBXO30 0.43 9.8 0.36 3.22e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.2 0.34 5.09e-19 Tonsillectomy; BRCA trans rs1941687 0.505 rs9956918 chr18:31315878 C/G cg27147174 chr7:100797783 AP1S1 0.38 7.9 0.3 1.26e-14 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7904368 0.806 rs45495501 chr10:16861476 G/A cg14835575 chr10:16859367 RSU1 0.62 12.96 0.46 2.76e-34 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs870825 0.616 rs28579226 chr4:185650458 A/C cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg22862634 chr11:62369728 EML3;MTA2 0.54 10.95 0.4 1.05e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs912057 0.965 rs1294409 chr6:6738355 A/G cg06612196 chr6:6737390 NA -0.46 -10.16 -0.37 1.43e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs7903847 0.620 rs9787454 chr10:99155561 A/T cg08345082 chr10:99160200 RRP12 -0.3 -8.72 -0.33 2.41e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.29 0.41 4.34e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17685 0.753 rs1574107 chr7:75685047 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.37 -0.31 3.5e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2832191 0.545 rs2251381 chr21:30530692 T/G cg24692254 chr21:30365293 RNF160 0.45 10.48 0.38 7.87e-24 Dental caries; BRCA cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg11266682 chr4:10021025 SLC2A9 -0.41 -10.74 -0.39 7.43e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs72928364 1.000 rs41273557 chr3:100621683 T/A cg10123952 chr3:100791384 NA 0.54 8.07 0.3 3.62e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs7809950 1.000 rs10243340 chr7:107090955 A/G cg23024343 chr7:107201750 COG5 -0.4 -9.3 -0.35 2.23e-19 Coronary artery disease; BRCA cis rs6087990 0.735 rs6058892 chr20:31388461 C/T cg13636640 chr20:31349939 DNMT3B 0.6 16.51 0.55 3.06e-51 Ulcerative colitis; BRCA cis rs6066835 1.000 rs6066833 chr20:47354494 G/C cg18078177 chr20:47281410 PREX1 0.69 8.6 0.32 6.2e-17 Multiple myeloma; BRCA cis rs1267303 0.637 rs1745371 chr1:46985192 C/T cg25110126 chr1:46999211 NA 0.49 9.46 0.35 6.02e-20 Monobrow; BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.06 20.01 0.62 1.58e-69 Platelet count; BRCA trans rs1493916 0.777 rs1493910 chr18:31318376 A/G cg27147174 chr7:100797783 AP1S1 -0.41 -8.04 -0.3 4.47e-15 Life satisfaction; BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -12.84 -0.45 9.7e-34 Alzheimer's disease; BRCA cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg08885076 chr2:99613938 TSGA10 -0.58 -12.89 -0.45 6.11e-34 Chronic sinus infection; BRCA cis rs7772486 0.686 rs702314 chr6:146003510 G/A cg23711669 chr6:146136114 FBXO30 -0.72 -17.12 -0.56 2.39e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6582630 0.576 rs4882258 chr12:38453686 C/T cg26384229 chr12:38710491 ALG10B -0.43 -10.0 -0.37 5.62e-22 Drug-induced liver injury (flucloxacillin); BRCA trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg17470723 chr8:74884337 TCEB1 0.4 8.64 0.32 4.37e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg01191920 chr7:158217561 PTPRN2 -0.46 -11.01 -0.4 6.11e-26 Obesity-related traits; BRCA cis rs7267979 1.000 rs2424716 chr20:25423538 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.32 9.05 0.34 1.65e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs16958440 1.000 rs60228288 chr18:44640412 G/A cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg14061069 chr19:46274453 DMPK -0.48 -12.08 -0.43 2.05e-30 Coronary artery disease; BRCA cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.39 0.35 1.06e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs7824557 0.652 rs12677504 chr8:11133175 G/A cg15556689 chr8:8085844 FLJ10661 -0.39 -9.35 -0.35 1.5e-19 Retinal vascular caliber; BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg00166722 chr3:10149974 C3orf24 0.66 13.26 0.46 1.33e-35 Alzheimer's disease; BRCA trans rs7829975 0.593 rs2921061 chr8:8317615 A/T cg21775007 chr8:11205619 TDH 0.45 9.23 0.34 3.93e-19 Mood instability; BRCA cis rs10782582 0.609 rs1796827 chr1:76391536 A/T cg03433033 chr1:76189801 ACADM -0.4 -8.46 -0.32 1.79e-16 Daytime sleep phenotypes; BRCA trans rs7746199 0.736 rs13202291 chr6:27698857 A/G cg01620082 chr3:125678407 NA -0.92 -10.32 -0.38 3.23e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs17270561 0.609 rs4712964 chr6:25740822 A/T cg16482183 chr6:26056742 HIST1H1C 0.47 9.01 0.34 2.39e-18 Iron status biomarkers; BRCA cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.52 0.32 1.17e-16 Rheumatoid arthritis; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg14196790 chr5:131705035 SLC22A5 0.33 8.56 0.32 8.38e-17 Breast cancer; BRCA cis rs9393692 0.875 rs12526215 chr6:26262916 T/C cg00631329 chr6:26305371 NA -0.42 -12.52 -0.44 2.45e-32 Educational attainment; BRCA cis rs17270561 0.609 rs4712964 chr6:25740822 A/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.92 0.33 4.82e-18 Iron status biomarkers; BRCA trans rs6952808 0.689 rs12670737 chr7:2046830 C/T cg04565464 chr8:145669602 NFKBIL2 0.35 8.47 0.32 1.74e-16 Bipolar disorder and schizophrenia; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg22963979 chr7:1858916 MAD1L1 -0.4 -8.29 -0.31 6.76e-16 Bipolar disorder and schizophrenia; BRCA cis rs514406 0.929 rs562178 chr1:53319562 T/C cg16325326 chr1:53192061 ZYG11B 0.7 17.53 0.57 1.73e-56 Monocyte count; BRCA cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg03605463 chr16:89740564 NA 0.57 9.63 0.36 1.35e-20 Vitiligo; BRCA cis rs7927592 0.913 rs10896330 chr11:68254998 A/G cg20283391 chr11:68216788 NA -0.46 -9.29 -0.34 2.45e-19 Total body bone mineral density; BRCA cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg25204440 chr1:209979598 IRF6 0.42 8.39 0.31 3.21e-16 Cleft lip with or without cleft palate; BRCA cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg27446573 chr6:127587934 RNF146 0.89 20.34 0.63 2.69e-71 Breast cancer; BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg22920501 chr2:26401640 FAM59B -0.81 -13.22 -0.46 1.9e-35 Gut microbiome composition (summer); BRCA cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs9341808 0.718 rs9343978 chr6:80971978 A/G cg08355045 chr6:80787529 NA 0.37 9.56 0.35 2.56e-20 Sitting height ratio; BRCA cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.99 -0.43 5.22e-30 Bipolar disorder; BRCA cis rs6964587 0.967 rs12531966 chr7:91765840 A/G cg01689657 chr7:91764605 CYP51A1 0.26 9.23 0.34 4.06e-19 Breast cancer; BRCA cis rs3820928 1.000 rs10210763 chr2:227776029 G/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.53e-16 Pulmonary function; BRCA cis rs11229555 0.645 rs11229459 chr11:58208025 G/A cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs151349 1.000 rs151345 chr20:57586849 G/C cg23907860 chr20:57583709 CTSZ -0.44 -10.78 -0.39 5.17e-25 Platelet distribution width; BRCA cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg25358565 chr5:93447407 FAM172A 1.21 18.49 0.59 1.84e-61 Diabetic retinopathy; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg27588902 chr6:42928151 GNMT -0.31 -10.17 -0.37 1.28e-22 Plasma homocysteine levels (post-methionine load test); BRCA cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg16405210 chr4:1374714 KIAA1530 -0.91 -22.75 -0.67 2.13e-84 Longevity; BRCA cis rs4689388 0.890 rs4689397 chr4:6299387 G/A cg00701064 chr4:6280414 WFS1 0.68 18.54 0.59 1e-61 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6484504 0.576 rs16922084 chr11:31371109 C/T cg14844989 chr11:31128820 NA 0.46 9.59 0.35 1.88e-20 Red blood cell count; BRCA cis rs11190604 1.000 rs2489051 chr10:102351785 C/T cg07080220 chr10:102295463 HIF1AN -0.58 -13.0 -0.46 1.92e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg00531865 chr16:30841666 NA -0.44 -10.27 -0.38 5.14e-23 Multiple myeloma; BRCA cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg26398791 chr1:38455867 SF3A3 -0.5 -11.93 -0.43 9.41e-30 Coronary artery disease; BRCA cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.91 0.74 1.14e-112 Chronic sinus infection; BRCA cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg12927641 chr6:109611667 NA 0.42 10.88 0.4 2.05e-25 Reticulocyte fraction of red cells; BRCA cis rs11809207 0.574 rs2783631 chr1:26504756 C/T cg00147160 chr1:26503991 CNKSR1 0.3 9.8 0.36 3.21e-21 Height; BRCA cis rs7246657 0.943 rs10426666 chr19:37828514 C/G cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg04944784 chr2:26401820 FAM59B -0.87 -13.54 -0.47 6.71e-37 Gut microbiome composition (summer); BRCA cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg03161606 chr19:29218774 NA 0.46 8.28 0.31 7.41e-16 Methadone dose in opioid dependence; BRCA cis rs6540556 0.769 rs2272867 chr1:209929579 C/A cg05527609 chr1:210001259 C1orf107 -0.44 -8.24 -0.31 9.62e-16 Red blood cell count; BRCA cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg05294307 chr14:35346193 BAZ1A -0.59 -10.37 -0.38 2.18e-23 Psoriasis; BRCA cis rs7149337 0.805 rs2999357 chr14:51606001 C/G cg23942311 chr14:51606299 NA 0.45 13.35 0.47 4.76e-36 Cancer; BRCA cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg00745463 chr17:30367425 LRRC37B -0.61 -9.71 -0.36 7.2e-21 Hip circumference adjusted for BMI; BRCA cis rs13136331 0.642 rs2869681 chr4:88620187 A/G cg22416721 chr4:88570574 DMP1 -0.47 -11.44 -0.41 1.02e-27 Sitting height ratio; BRCA cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg00012203 chr2:219082015 ARPC2 -0.57 -12.01 -0.43 4.3e-30 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7246657 0.653 rs4805207 chr19:37673733 G/A cg23950597 chr19:37808831 NA -0.66 -10.28 -0.38 4.82e-23 Coronary artery calcification; BRCA cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.43 -0.32 2.22e-16 Colorectal cancer; BRCA cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 10.41 0.38 1.48e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg08045932 chr20:61659980 NA 0.49 11.29 0.41 4.65e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg21017887 chr14:105400489 NA 0.65 17.45 0.57 4.43e-56 Rheumatoid arthritis; BRCA cis rs7560272 0.501 rs6755500 chr2:73942233 C/T cg20560298 chr2:73613845 ALMS1 0.35 8.93 0.33 4.32e-18 Schizophrenia; BRCA cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.01e-15 Alzheimer's disease (late onset); BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.01 -22.16 -0.66 3.76e-81 Gut microbiome composition (summer); BRCA cis rs17685 0.753 rs2286830 chr7:75693963 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.39 8.81 0.33 1.16e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg20887711 chr4:1340912 KIAA1530 0.42 10.16 0.37 1.4e-22 Longevity; BRCA cis rs595982 0.559 rs73061632 chr19:49361663 G/A cg15549821 chr19:49342101 PLEKHA4 -0.74 -11.91 -0.43 1.11e-29 Red cell distribution width; BRCA cis rs7474896 0.507 rs2474555 chr10:38465220 G/C cg25427524 chr10:38739819 LOC399744 -0.59 -10.18 -0.37 1.21e-22 Obesity (extreme); BRCA cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg08822215 chr16:89438651 ANKRD11 -0.4 -8.32 -0.31 5.39e-16 Multiple myeloma (IgH translocation); BRCA cis rs708547 0.578 rs781665 chr4:57831461 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -8.16 -0.31 1.73e-15 Response to bleomycin (chromatid breaks); BRCA cis rs3796352 1.000 rs13072395 chr3:52980573 T/C cg07884673 chr3:53033167 SFMBT1 0.85 9.61 0.36 1.7e-20 Immune reponse to smallpox (secreted IL-2); BRCA cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg24812749 chr6:127587940 RNF146 0.86 19.78 0.62 2.55e-68 Breast cancer; BRCA trans rs1994135 0.647 rs66542958 chr12:33695385 T/G cg26384229 chr12:38710491 ALG10B 0.52 10.93 0.4 1.33e-25 Resting heart rate; BRCA cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg21918786 chr6:109611834 NA -0.44 -11.83 -0.42 2.47e-29 Reticulocyte fraction of red cells; BRCA trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.14 -0.31 2.03e-15 Menarche (age at onset); BRCA cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg02475777 chr4:1388615 CRIPAK 0.67 12.68 0.45 5.08e-33 Longevity; BRCA cis rs4285028 0.848 rs77630152 chr3:121681194 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.72 -0.39 8.65e-25 Multiple sclerosis; BRCA trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg13010199 chr12:38710504 ALG10B 0.43 9.22 0.34 4.33e-19 Morning vs. evening chronotype; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -13.14 -0.46 4.35e-35 Lymphocyte counts; BRCA cis rs26949 0.511 rs11740327 chr5:59899413 G/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.47 0.35 5.42e-20 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg11843238 chr5:131593191 PDLIM4 0.41 10.35 0.38 2.63e-23 Acylcarnitine levels; BRCA cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg01849466 chr14:104193079 ZFYVE21 -0.42 -10.79 -0.39 4.75e-25 Schizophrenia; BRCA cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg10876282 chr6:28092338 ZSCAN16 0.4 7.89 0.3 1.29e-14 Parkinson's disease; BRCA cis rs250677 0.687 rs42364 chr5:148438858 T/A cg12140854 chr5:148520817 ABLIM3 -0.42 -8.96 -0.33 3.64e-18 Breast cancer; BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00166722 chr3:10149974 C3orf24 0.58 10.03 0.37 4.48e-22 Alzheimer's disease; BRCA cis rs1003719 0.553 rs1063948 chr21:38574674 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs17401966 0.838 rs11579365 chr1:10470846 G/T cg03954927 chr1:10346856 KIF1B 0.43 13.08 0.46 8.43e-35 Hepatocellular carcinoma; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg14863265 chr7:2801509 GNA12 -0.43 -9.25 -0.34 3.26e-19 Height; BRCA cis rs2425143 1.000 rs55761608 chr20:34344226 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.02 -0.34 2.18e-18 Blood protein levels; BRCA cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg17971929 chr21:40555470 PSMG1 -0.62 -14.23 -0.49 4.23e-40 Cognitive function; BRCA cis rs2012796 0.913 rs8010181 chr14:81820125 T/C cg02996355 chr14:81879375 NA 0.43 8.61 0.32 5.54e-17 Night sleep phenotypes; BRCA cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg00254258 chr1:3105189 PRDM16 -0.47 -11.11 -0.4 2.51e-26 Migraine; BRCA cis rs9790314 1.000 rs6775627 chr3:160953609 A/G cg03342759 chr3:160939853 NMD3 -0.63 -13.37 -0.47 3.85e-36 Morning vs. evening chronotype; BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg19626725 chr5:178986131 RUFY1 -0.34 -10.66 -0.39 1.61e-24 Lung cancer; BRCA cis rs2404602 0.684 rs4886819 chr15:76901698 C/T cg23625390 chr15:77176239 SCAPER -0.54 -13.38 -0.47 3.53e-36 Blood metabolite levels; BRCA cis rs631288 0.557 rs2354434 chr1:146679428 A/G cg25205988 chr1:146714368 CHD1L 0.82 8.01 0.3 5.33e-15 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg03433033 chr1:76189801 ACADM -0.88 -28.26 -0.75 1.36e-114 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs3733585 0.699 rs7699609 chr4:9961059 A/G cg26043149 chr18:55253948 FECH -0.38 -8.4 -0.32 2.97e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7824557 0.564 rs2736295 chr8:11234780 C/G cg21775007 chr8:11205619 TDH 0.63 14.5 0.5 2.03e-41 Retinal vascular caliber; BRCA cis rs910316 0.737 rs175084 chr14:75519175 C/T cg23033748 chr14:75592666 NEK9 -0.34 -7.98 -0.3 6.93e-15 Height; BRCA cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.76 -0.33 1.77e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.52 0.35 3.41e-20 Motion sickness; BRCA cis rs9325144 0.600 rs10785621 chr12:38744912 C/T cg26384229 chr12:38710491 ALG10B 0.48 12.36 0.44 1.28e-31 Morning vs. evening chronotype; BRCA cis rs1843834 0.898 rs12623277 chr2:225548072 T/G cg22455342 chr2:225449267 CUL3 0.34 8.29 0.31 6.67e-16 IgE levels in asthmatics (D.p. specific); BRCA cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg23422044 chr7:1970798 MAD1L1 -0.59 -10.6 -0.39 2.7e-24 Bipolar disorder; BRCA cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.09 0.46 7.12e-35 Intelligence (multi-trait analysis); BRCA cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg07395648 chr5:131743802 NA -0.38 -8.3 -0.31 6.16e-16 Breast cancer; BRCA cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs220324 0.688 rs715744 chr21:43565503 G/C cg09727148 chr21:43560719 UMODL1 0.44 7.87 0.3 1.5e-14 Idiopathic osteonecrosis of the femoral head; BRCA trans rs6598955 0.671 rs6686100 chr1:26617338 G/C cg07461501 chr17:79650226 HGS;ARL16 -0.68 -15.92 -0.53 2.61e-48 Obesity-related traits; BRCA cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg08000102 chr2:233561755 GIGYF2 0.63 13.95 0.48 8.3e-39 Coronary artery disease; BRCA cis rs7666738 0.753 rs10029372 chr4:98859002 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.56 0.5 1.14e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs2050392 0.517 rs603072 chr10:30755778 C/T cg18806716 chr10:30721971 MAP3K8 0.41 9.96 0.37 8.35e-22 Inflammatory bowel disease; BRCA cis rs921968 0.541 rs12617603 chr2:219369288 A/G cg02176678 chr2:219576539 TTLL4 -0.5 -12.73 -0.45 3.13e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs3087591 0.920 rs11080150 chr17:29629326 A/G cg24425628 chr17:29625626 OMG;NF1 -0.45 -8.98 -0.33 2.97e-18 Hip circumference; BRCA cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg00684032 chr4:1343700 KIAA1530 0.31 7.98 0.3 6.79e-15 Obesity-related traits; BRCA trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.29 -0.34 2.36e-19 Extrinsic epigenetic age acceleration; BRCA cis rs6558530 0.965 rs6558529 chr8:1706206 C/T cg19131313 chr8:1704013 NA -0.35 -7.86 -0.3 1.69e-14 Systolic blood pressure; BRCA cis rs4285028 0.948 rs76593525 chr3:121690477 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.88 -0.4 2.15e-25 Multiple sclerosis; BRCA cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.703 rs351755 chr6:109538073 G/A cg01475377 chr6:109611718 NA 0.45 11.23 0.41 7.99e-27 Reticulocyte fraction of red cells; BRCA cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.11e-40 Motion sickness; BRCA cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg26384229 chr12:38710491 ALG10B 0.72 16.78 0.55 1.2e-52 Drug-induced liver injury (flucloxacillin); BRCA cis rs4730250 0.708 rs4730242 chr7:107057373 G/C cg02696742 chr7:106810147 HBP1 -0.54 -8.13 -0.31 2.17e-15 Osteoarthritis; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg18402987 chr7:1209562 NA -0.49 -9.4 -0.35 9.79e-20 Longevity;Endometriosis; BRCA cis rs1580019 0.961 rs2392056 chr7:32498953 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.2 0.54 1.04e-49 Cognitive ability; BRCA cis rs921968 0.541 rs10200507 chr2:219335944 C/A cg10223061 chr2:219282414 VIL1 0.3 8.55 0.32 9.43e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs6484504 0.652 rs578666 chr11:31404484 C/T cg26647111 chr11:31128758 NA 0.45 9.73 0.36 6e-21 Red blood cell count; BRCA cis rs17818399 0.620 rs1080871 chr2:46854708 A/G cg02822958 chr2:46747628 ATP6V1E2 0.41 8.0 0.3 5.75e-15 Height; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.58 -11.48 -0.41 7.39e-28 Lymphocyte counts; BRCA cis rs490234 0.966 rs509753 chr9:128303518 G/A cg14078157 chr9:128172775 NA 0.33 7.89 0.3 1.3e-14 Mean arterial pressure; BRCA trans rs11098499 0.863 rs2291185 chr4:120434833 C/A cg25214090 chr10:38739885 LOC399744 0.55 12.24 0.44 4.27e-31 Corneal astigmatism; BRCA cis rs7927592 0.913 rs12294029 chr11:68257059 A/C cg20283391 chr11:68216788 NA -0.45 -9.32 -0.35 1.81e-19 Total body bone mineral density; BRCA cis rs9309473 0.687 rs11693531 chr2:73608614 C/G cg20560298 chr2:73613845 ALMS1 -0.52 -14.21 -0.49 5.14e-40 Metabolite levels; BRCA cis rs586533 0.846 rs593538 chr11:99498435 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.06 0.3 3.7e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs897984 0.520 rs4889536 chr16:30871755 G/T cg02466173 chr16:30829666 NA 0.46 9.31 0.35 1.99e-19 Dementia with Lewy bodies; BRCA cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg21573476 chr21:45109991 RRP1B -0.49 -12.68 -0.45 5.06e-33 Mean corpuscular volume; BRCA cis rs7760949 0.889 rs9396264 chr6:13930342 T/A cg27413430 chr6:13925136 RNF182 0.46 9.3 0.35 2.2e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs7577696 0.597 rs7556942 chr2:32295694 G/A cg02381751 chr2:32503542 YIPF4 -0.42 -8.01 -0.3 5.47e-15 Inflammatory biomarkers; BRCA cis rs1997103 0.863 rs4480062 chr7:55401299 T/C cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.58 -0.32 7.19e-17 Total body bone mineral density; BRCA cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg19678392 chr7:94953810 PON1 -0.42 -8.84 -0.33 9.34e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2249625 0.523 rs2496501 chr6:72885364 A/G cg18830697 chr6:72922368 RIMS1 -0.63 -14.36 -0.49 9.82e-41 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg06115741 chr20:33292138 TP53INP2 -0.37 -8.22 -0.31 1.17e-15 Glomerular filtration rate (creatinine); BRCA cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg13119609 chr19:45449297 APOC2 0.47 13.08 0.46 8.51e-35 Blood protein levels; BRCA cis rs11792861 0.888 rs75543406 chr9:111816903 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.81 0.3 2.43e-14 Menarche (age at onset); BRCA cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg13770153 chr20:60521292 NA -0.45 -10.87 -0.39 2.31e-25 Body mass index; BRCA cis rs7511006 1.000 rs17836662 chr22:50672154 A/G cg16473166 chr22:50639996 SELO -0.49 -11.07 -0.4 3.5e-26 Obesity-related traits; BRCA cis rs6714710 0.603 rs11684749 chr2:98420142 G/C cg26665480 chr2:98280029 ACTR1B 0.58 13.61 0.47 3.29e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA trans rs877282 0.755 rs2486579 chr10:785647 G/A cg22713356 chr15:30763199 NA 1.09 21.7 0.65 1.18e-78 Uric acid levels; BRCA cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.2 0.56 8.9e-55 Bladder cancer; BRCA cis rs9814567 0.806 rs12637301 chr3:134317966 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -10.74 -0.39 7.19e-25 IgG glycosylation; BRCA cis rs727479 0.545 rs10851499 chr15:51537127 G/C cg19946085 chr15:51559439 CYP19A1 -0.29 -7.84 -0.3 1.89e-14 Estradiol levels; BRCA cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg14847009 chr1:175162515 KIAA0040 0.25 9.47 0.35 5.34e-20 Alcohol dependence; BRCA cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.55 0.32 8.93e-17 Glomerular filtration rate (creatinine); BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg12419862 chr22:24373484 LOC391322 -0.69 -15.85 -0.53 5.94e-48 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.03 0.3 4.83e-15 Diabetic retinopathy; BRCA cis rs16854884 0.657 rs6769910 chr3:143737830 C/G cg06585982 chr3:143692056 C3orf58 0.43 8.99 0.33 2.87e-18 Economic and political preferences (feminism/equality); BRCA cis rs6977660 0.714 rs10155949 chr7:19834747 T/C cg05791153 chr7:19748676 TWISTNB 0.58 10.74 0.39 7.76e-25 Thyroid stimulating hormone; BRCA cis rs870825 0.616 rs6810600 chr4:185616814 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.17 0.56 1.32e-54 Blood protein levels; BRCA cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.69 0.5 2.56e-42 Personality dimensions; BRCA cis rs7447593 0.518 rs4074995 chr5:176797343 C/T cg06060754 chr5:176797920 RGS14 0.94 19.24 0.61 2.09e-65 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs4787491 0.729 rs11150584 chr16:30039678 C/A cg06326092 chr16:30034487 C16orf92 0.37 9.46 0.35 5.69e-20 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs3740540 0.530 rs2362507 chr10:126290820 A/G cg04949429 chr10:126290192 LHPP 0.43 12.26 0.44 3.62e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs524281 0.817 rs10791859 chr11:65978453 C/T cg16950941 chr11:66035639 RAB1B -0.38 -8.11 -0.31 2.58e-15 Electroencephalogram traits; BRCA trans rs6479901 0.512 rs4439410 chr10:64998772 C/G cg14819942 chr15:35414228 NA -0.35 -8.65 -0.32 4.26e-17 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.664 rs9525873 chr13:44482204 T/C cg17145862 chr1:211918768 LPGAT1 0.51 11.61 0.42 2.13e-28 Leprosy; BRCA cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg12193833 chr17:30244370 NA -0.61 -9.26 -0.34 3.03e-19 Hip circumference adjusted for BMI; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.48 -0.44 3.66e-32 Lymphocyte counts; BRCA cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg27535305 chr1:53392650 SCP2 0.49 11.37 0.41 2.12e-27 Monocyte count; BRCA trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.01 0.3 5.51e-15 Corneal astigmatism; BRCA cis rs6878727 0.850 rs10055879 chr5:123704258 G/A cg01806427 chr5:123737813 NA 0.42 8.65 0.32 4.29e-17 Breast cancer; BRCA cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.03 0.3 4.7e-15 Breast cancer; BRCA cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg01939980 chr4:1354348 KIAA1530 0.38 9.05 0.34 1.73e-18 Obesity-related traits; BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.08 0.3 3.34e-15 Tonsillectomy; BRCA cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg01884057 chr2:25150051 NA 0.31 8.09 0.3 3.08e-15 Body mass index; BRCA cis rs17604090 0.938 rs850029 chr7:29678087 A/G cg19413766 chr7:29689036 LOC646762 -0.55 -7.96 -0.3 7.86e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs2839186 0.739 rs7282763 chr21:47696800 C/T cg12379764 chr21:47803548 PCNT -0.38 -8.24 -0.31 9.57e-16 Testicular germ cell tumor; BRCA cis rs6545883 0.783 rs7579651 chr2:61800279 C/G cg15711740 chr2:61764176 XPO1 -0.57 -14.38 -0.49 8.14e-41 Tuberculosis; BRCA trans rs9944715 0.954 rs7240354 chr18:43809614 G/A cg01718231 chr17:29326311 RNF135 -0.4 -8.04 -0.3 4.47e-15 Red cell distribution width;Mean corpuscular volume; BRCA cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg12310025 chr6:25882481 NA -0.55 -13.62 -0.47 2.93e-37 Blood metabolite levels; BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg27170947 chr2:26402098 FAM59B -0.99 -17.47 -0.57 3.52e-56 Gut microbiome composition (summer); BRCA cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs12579753 0.810 rs1922565 chr12:82135348 T/C cg07988820 chr12:82153109 PPFIA2 -0.61 -10.97 -0.4 8.61e-26 Resting heart rate; BRCA cis rs9646954 0.542 rs3828193 chr2:101031561 A/C cg14675211 chr2:100938903 LONRF2 -0.52 -11.21 -0.41 9.33e-27 Intelligence (multi-trait analysis); BRCA cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg18876405 chr7:65276391 NA 0.71 18.24 0.59 3.68e-60 Calcium levels; BRCA cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.47 0.32 1.68e-16 Bone mineral density; BRCA cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.54 -10.39 -0.38 1.83e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs34779708 0.702 rs35969476 chr10:35544318 G/A cg03585969 chr10:35415529 CREM 0.45 9.1 0.34 1.11e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg14784868 chr12:69753453 YEATS4 0.45 11.79 0.42 3.52e-29 Blood protein levels; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg00024416 chr22:24240387 NA 0.32 8.04 0.3 4.22e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9325144 0.647 rs61930266 chr12:38922048 A/G cg26384229 chr12:38710491 ALG10B -0.52 -12.44 -0.44 5.95e-32 Morning vs. evening chronotype; BRCA cis rs4478858 0.735 rs68008576 chr1:31805905 T/C cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA trans rs75804782 0.521 rs72993073 chr2:239412925 G/A cg01134436 chr17:81009848 B3GNTL1 0.68 8.52 0.32 1.11e-16 Morning vs. evening chronotype;Chronotype; BRCA cis rs6763687 0.964 rs16856859 chr3:171784736 A/G cg16233210 chr3:171778391 FNDC3B 0.49 11.77 0.42 4.59e-29 Red cell distribution width; BRCA cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg21017887 chr14:105400489 NA 0.66 17.48 0.57 3.47e-56 Rheumatoid arthritis; BRCA cis rs1165668 0.755 rs10735390 chr12:104311731 A/G cg21863207 chr12:104234989 NT5DC3 0.39 8.19 0.31 1.37e-15 Coronary heart disease (SNP X SNP interaction); BRCA cis rs12541635 0.934 rs2115703 chr8:107045935 C/G cg10147462 chr8:107024639 NA 0.37 9.62 0.36 1.46e-20 Age of smoking initiation; BRCA cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg15145296 chr3:125709740 NA -0.56 -8.92 -0.33 5.06e-18 Blood pressure (smoking interaction); BRCA cis rs1580019 0.844 rs1376290 chr7:32486922 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.89 19.33 0.61 7.04e-66 Cognitive ability; BRCA cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg18876405 chr7:65276391 NA 0.52 12.2 0.43 6.26e-31 Aortic root size; BRCA cis rs12368653 0.840 rs3816896 chr12:58195773 C/T cg00677455 chr12:58241039 CTDSP2 -0.41 -9.31 -0.35 2.07e-19 Multiple sclerosis; BRCA cis rs34779708 0.931 rs34876468 chr10:35424450 G/A cg03585969 chr10:35415529 CREM 0.56 11.38 0.41 1.82e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7927771 0.560 rs4752858 chr11:47685829 C/T cg20307385 chr11:47447363 PSMC3 -0.39 -9.1 -0.34 1.13e-18 Subjective well-being; BRCA cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg08992911 chr2:238395768 MLPH 0.38 8.38 0.31 3.37e-16 Prostate cancer; BRCA cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.31 0.41 3.68e-27 Electroencephalogram traits; BRCA cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg01884057 chr2:25150051 NA 0.33 8.28 0.31 7.49e-16 Body mass index; BRCA cis rs11229555 0.645 rs4517537 chr11:58213695 G/A cg15696309 chr11:58395628 NA -0.45 -9.64 -0.36 1.27e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7394190 0.748 rs4746147 chr10:75527708 A/G cg07699608 chr10:75541558 CHCHD1 0.65 9.66 0.36 1.06e-20 Incident atrial fibrillation; BRCA trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.54 17.21 0.56 7.93e-55 Intelligence (multi-trait analysis); BRCA cis rs938554 0.513 rs3775947 chr4:9995240 C/T cg00071950 chr4:10020882 SLC2A9 0.4 8.43 0.32 2.27e-16 Blood metabolite levels; BRCA cis rs73001065 1.000 rs73001065 chr19:19460541 G/C cg03709012 chr19:19516395 GATAD2A 0.88 7.89 0.3 1.36e-14 LDL cholesterol; BRCA cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg02659138 chr7:134003124 SLC35B4 0.34 10.73 0.39 8.26e-25 Mean platelet volume; BRCA cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA trans rs7474896 0.616 rs2474561 chr10:38373544 C/T cg17830980 chr10:43048298 ZNF37B -0.45 -8.05 -0.3 4.16e-15 Obesity (extreme); BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.29 -0.31 6.93e-16 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg17366294 chr4:99064904 C4orf37 0.41 9.37 0.35 1.21e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs7246967 0.611 rs34806882 chr19:22880104 T/C cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs2859741 0.647 rs548661 chr1:37479392 T/G cg09363841 chr1:37513479 NA -0.56 -11.98 -0.43 5.48e-30 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs6546550 0.835 rs3755389 chr2:70119469 T/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.94e-28 Prevalent atrial fibrillation; BRCA cis rs17092148 0.616 rs1122174 chr20:33110846 T/C cg16810054 chr20:33298113 TP53INP2 -0.43 -9.41 -0.35 9e-20 Neuroticism; BRCA cis rs7592578 0.882 rs61117285 chr2:191468986 G/C cg10560079 chr2:191398806 TMEM194B -0.71 -12.48 -0.44 3.92e-32 Diastolic blood pressure; BRCA cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg13010199 chr12:38710504 ALG10B 0.54 11.51 0.41 5.6e-28 Heart rate; BRCA cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg10523679 chr1:76189770 ACADM 0.76 15.98 0.53 1.34e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg14829155 chr15:31115871 NA -0.33 -8.01 -0.3 5.32e-15 Huntington's disease progression; BRCA cis rs861020 1.000 rs861020 chr1:209977111 A/G cg09163369 chr1:210001066 C1orf107 0.51 9.44 0.35 6.65e-20 Orofacial clefts; BRCA cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs11098499 1.000 rs28374891 chr4:120183550 G/A cg09307838 chr4:120376055 NA 0.61 12.33 0.44 1.65e-31 Corneal astigmatism; BRCA cis rs2882667 0.898 rs6882330 chr5:138382182 A/G cg04439458 chr5:138467593 SIL1 -0.33 -8.99 -0.33 2.85e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs495337 0.760 rs4810995 chr20:48571802 C/A cg17835207 chr20:48524531 SPATA2 -0.69 -16.88 -0.56 3.73e-53 Psoriasis; BRCA cis rs17401966 1.000 rs4846208 chr1:10313839 T/C cg15208524 chr1:10270712 KIF1B 0.39 8.43 0.32 2.24e-16 Hepatocellular carcinoma; BRCA cis rs875971 0.929 rs778682 chr7:65837934 A/G cg18876405 chr7:65276391 NA 0.55 13.29 0.47 9.4e-36 Aortic root size; BRCA cis rs875971 0.862 rs709596 chr7:65825913 A/G cg11764359 chr7:65958608 NA 0.76 17.57 0.57 1.11e-56 Aortic root size; BRCA cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg24060327 chr5:131705240 SLC22A5 0.61 12.0 0.43 4.85e-30 Breast cancer; BRCA trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.04e-14 Corneal astigmatism; BRCA cis rs1891275 0.509 rs76313529 chr10:93443076 T/C cg07889827 chr10:93443413 NA -0.44 -12.54 -0.44 2.03e-32 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg04455712 chr21:45112962 RRP1B 0.39 10.18 0.37 1.19e-22 Mean corpuscular volume; BRCA cis rs2455799 0.634 rs13085226 chr3:15923750 C/T cg16303742 chr3:15540471 COLQ -0.33 -7.89 -0.3 1.34e-14 Mean platelet volume; BRCA cis rs80130819 0.515 rs1635536 chr12:48385945 A/G cg05342945 chr12:48394962 COL2A1 -0.5 -9.62 -0.36 1.45e-20 Prostate cancer; BRCA cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg04756594 chr16:24857601 SLC5A11 -0.34 -8.62 -0.32 5.2e-17 Intelligence (multi-trait analysis); BRCA cis rs11792861 0.888 rs11794648 chr9:111829792 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.5 0.32 1.39e-16 Menarche (age at onset); BRCA cis rs4948102 0.727 rs4948097 chr7:56056571 A/G cg09872392 chr7:56161020 PHKG1 -0.4 -9.08 -0.34 1.39e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs2742234 0.590 rs2075912 chr10:43622217 T/C cg02780029 chr10:43622663 RET -0.35 -7.86 -0.3 1.64e-14 Hirschsprung disease; BRCA cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg01579765 chr21:45077557 HSF2BP -0.36 -8.75 -0.33 1.91e-17 Mean corpuscular volume; BRCA cis rs654950 0.653 rs2810568 chr1:42054247 A/G cg06885757 chr1:42089581 HIVEP3 -0.33 -10.94 -0.4 1.22e-25 Airway imaging phenotypes; BRCA trans rs637571 0.584 rs659824 chr11:65636509 A/G cg17712092 chr4:129076599 LARP1B -0.57 -13.28 -0.47 1.07e-35 Eosinophil percentage of white cells; BRCA cis rs9369695 0.883 rs9381581 chr6:47580695 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.58 0.35 2.15e-20 Reticulocyte count; BRCA cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12756686 chr19:29218302 NA 0.55 10.85 0.39 2.75e-25 Methadone dose in opioid dependence; BRCA cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg15395560 chr15:45543142 SLC28A2 -0.29 -7.84 -0.3 1.9e-14 Uric acid levels; BRCA trans rs3733585 0.673 rs9993410 chr4:9951264 C/T cg26043149 chr18:55253948 FECH -0.36 -8.05 -0.3 3.98e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg11707556 chr5:10655725 ANKRD33B -0.41 -8.94 -0.33 4e-18 Coronary artery disease; BRCA cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.65 -0.5 4.27e-42 Chronic sinus infection; BRCA cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg08514558 chr10:81106712 PPIF 0.36 8.72 0.33 2.34e-17 Height; BRCA trans rs7395662 0.833 rs1963073 chr11:48975094 T/A cg00717180 chr2:96193071 NA -0.31 -8.61 -0.32 5.68e-17 HDL cholesterol; BRCA trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg14343924 chr8:8086146 FLJ10661 0.42 8.51 0.32 1.23e-16 Neuroticism; BRCA cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg06494592 chr3:125709126 NA -0.53 -8.23 -0.31 1.05e-15 Blood pressure (smoking interaction); BRCA cis rs17401966 0.931 rs3748577 chr1:10357406 C/T cg03954927 chr1:10346856 KIF1B -0.47 -15.0 -0.51 8.74e-44 Hepatocellular carcinoma; BRCA cis rs838147 0.844 rs12975033 chr19:49249443 A/T cg13540341 chr19:49222985 MAMSTR 0.3 7.88 0.3 1.39e-14 Dietary macronutrient intake; BRCA cis rs1865721 0.804 rs1319789 chr18:73161157 C/A cg26385618 chr18:73139727 C18orf62 -0.41 -9.85 -0.36 2.02e-21 Intelligence; BRCA cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg23018236 chr17:30244563 NA -0.72 -12.04 -0.43 3.26e-30 Hip circumference adjusted for BMI; BRCA cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg23625390 chr15:77176239 SCAPER 0.37 8.87 0.33 7.19e-18 Blood metabolite levels; BRCA cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg25801113 chr15:45476975 SHF -0.34 -8.39 -0.31 3.14e-16 Uric acid levels; BRCA cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.86 0.39 2.45e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs13315871 0.929 rs11706920 chr3:58279672 C/T cg20936604 chr3:58311152 NA -0.65 -8.19 -0.31 1.44e-15 Cholesterol, total; BRCA cis rs977987 0.806 rs11862095 chr16:75385418 T/A cg03315344 chr16:75512273 CHST6 0.52 12.29 0.44 2.58e-31 Dupuytren's disease; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.14 -0.31 2.08e-15 Total body bone mineral density; BRCA cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg18876405 chr7:65276391 NA 0.55 13.18 0.46 3.03e-35 Aortic root size; BRCA cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg25019033 chr10:957182 NA -0.41 -7.91 -0.3 1.11e-14 Eosinophil percentage of granulocytes; BRCA cis rs6715284 1.000 rs13398075 chr2:202376269 A/T cg08521270 chr2:202316462 TRAK2;STRADB 0.66 8.83 0.33 1.03e-17 Rheumatoid arthritis; BRCA trans rs6951245 0.872 rs77434655 chr7:1098405 G/A cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg25237894 chr2:233734115 C2orf82 -0.44 -13.82 -0.48 3.21e-38 Coronary artery disease; BRCA cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg24692254 chr21:30365293 RNF160 0.79 22.05 0.66 1.52e-80 Dental caries; BRCA cis rs7246657 0.722 rs10403173 chr19:38078680 G/A cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs1865721 0.804 rs72977818 chr18:73146852 T/C cg26385618 chr18:73139727 C18orf62 -0.44 -10.79 -0.39 4.95e-25 Intelligence; BRCA cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg11764359 chr7:65958608 NA -0.74 -16.09 -0.54 3.77e-49 Aortic root size; BRCA cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg24060327 chr5:131705240 SLC22A5 0.61 11.38 0.41 1.91e-27 Breast cancer; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg18402987 chr7:1209562 NA 0.85 12.22 0.44 5.38e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs10771431 0.935 rs1988852 chr12:9372862 G/A cg27600084 chr12:12264075 NA 0.4 9.21 0.34 4.65e-19 Breast size; BRCA cis rs13136331 0.642 rs1319917 chr4:88628808 G/C cg22416721 chr4:88570574 DMP1 -0.47 -11.48 -0.41 6.94e-28 Sitting height ratio; BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg27071517 chr21:31768726 KRTAP13-1 0.29 7.92 0.3 1.08e-14 HDL cholesterol; BRCA cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg12310025 chr6:25882481 NA -0.55 -13.63 -0.47 2.52e-37 Blood metabolite levels; BRCA cis rs9815354 0.812 rs73071212 chr3:41981856 C/A cg03022575 chr3:42003672 ULK4 0.7 9.67 0.36 9.51e-21 Pulse pressure;Diastolic blood pressure; BRCA trans rs561341 1.000 rs527256 chr17:30321293 C/G cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.26e-27 Hip circumference adjusted for BMI; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg16145915 chr7:1198662 ZFAND2A -0.65 -17.6 -0.57 8.16e-57 Longevity;Endometriosis; BRCA cis rs965469 0.625 rs1043159 chr20:3232031 C/T cg25506879 chr20:3388711 C20orf194 -0.46 -9.63 -0.36 1.35e-20 IFN-related cytopenia; BRCA trans rs11250097 0.549 rs11784897 chr8:11310442 G/A cg06636001 chr8:8085503 FLJ10661 -0.51 -10.12 -0.37 1.99e-22 Neuroticism; BRCA cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.871 rs339114 chr3:161109220 C/T cg04691961 chr3:161091175 C3orf57 0.46 10.95 0.4 1.05e-25 Morning vs. evening chronotype; BRCA cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg12193833 chr17:30244370 NA -0.54 -8.72 -0.33 2.47e-17 Hip circumference adjusted for BMI; BRCA cis rs11098499 0.908 rs28499576 chr4:120386677 G/A cg09307838 chr4:120376055 NA 0.76 17.1 0.56 2.87e-54 Corneal astigmatism; BRCA cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg26031613 chr14:104095156 KLC1 0.73 15.91 0.53 2.85e-48 Bone mineral density; BRCA cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg04398451 chr17:18023971 MYO15A 0.66 14.55 0.5 1.25e-41 Total body bone mineral density; BRCA cis rs965469 1.000 rs6037535 chr20:3270621 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -10.19 -0.37 1.08e-22 IFN-related cytopenia; BRCA cis rs68170813 0.559 rs6963917 chr7:106953427 T/G cg02696742 chr7:106810147 HBP1 -0.54 -8.72 -0.33 2.46e-17 Coronary artery disease; BRCA trans rs7647973 0.626 rs7649428 chr3:49868876 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.38 7.96 0.3 8.16e-15 Menarche (age at onset); BRCA cis rs3008870 1.000 rs3008854 chr1:67385951 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.74 0.65 7.41e-79 Lymphocyte percentage of white cells; BRCA cis rs4363385 0.818 rs406350 chr1:153007492 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs4363385 0.747 rs1984198 chr1:152958584 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.84e-16 Inflammatory skin disease; BRCA trans rs11098499 0.865 rs1112817 chr4:120297800 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.87e-21 Colorectal cancer; BRCA cis rs7809950 0.862 rs62482502 chr7:106987810 A/C cg23024343 chr7:107201750 COG5 -0.4 -9.13 -0.34 8.84e-19 Coronary artery disease; BRCA cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs6687430 0.526 rs6688558 chr1:10611403 A/G cg17425144 chr1:10567563 PEX14 0.51 11.9 0.43 1.18e-29 Hand grip strength; BRCA cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg03354898 chr7:1950403 MAD1L1 0.44 9.34 0.35 1.59e-19 Bipolar disorder and schizophrenia; BRCA cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg05084668 chr3:125655381 ALG1L -0.47 -8.1 -0.31 2.84e-15 Blood pressure (smoking interaction); BRCA cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.66 0.71 2.38e-100 Chronic sinus infection; BRCA cis rs875971 0.862 rs801194 chr7:66028495 T/C cg18876405 chr7:65276391 NA -0.5 -11.01 -0.4 6.21e-26 Aortic root size; BRCA cis rs7903847 0.642 rs4635018 chr10:99137839 C/G cg20016023 chr10:99160130 RRP12 0.27 8.59 0.32 6.62e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6547741 1.000 rs1528404 chr2:27846603 C/T cg27432699 chr2:27873401 GPN1 -0.41 -8.83 -0.33 9.84e-18 Oral cavity cancer; BRCA cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg22467129 chr15:76604101 ETFA -0.49 -10.77 -0.39 5.61e-25 Blood metabolite levels; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs4363385 0.747 rs4845506 chr1:152968407 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.08 -0.34 1.35e-18 Inflammatory skin disease; BRCA cis rs965469 0.779 rs6037571 chr20:3334322 C/T cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA cis rs1868673 1.000 rs1868672 chr3:150175231 T/C cg04908077 chr3:150187338 NA -0.32 -8.62 -0.32 5.31e-17 Waist circumference; BRCA cis rs9986765 0.881 rs73452602 chr7:142828331 A/T cg22531018 chr7:142981779 TMEM139 0.58 9.69 0.36 7.99e-21 Cancer;Dermatomyositis; BRCA cis rs4363385 0.818 rs406350 chr1:153007492 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg02297831 chr4:17616191 MED28 0.36 8.38 0.31 3.46e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg12564285 chr5:131593104 PDLIM4 -0.44 -11.7 -0.42 8.46e-29 Acylcarnitine levels; BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg00106254 chr7:1943704 MAD1L1 -0.39 -9.65 -0.36 1.21e-20 Bipolar disorder and schizophrenia; BRCA cis rs1797081 0.811 rs1797076 chr10:16853076 A/G cg14835575 chr10:16859367 RSU1 0.31 7.81 0.3 2.29e-14 Platelet distribution width; BRCA cis rs10267417 0.603 rs4543442 chr7:19911140 G/A cg07541023 chr7:19748670 TWISTNB 0.45 8.01 0.3 5.54e-15 Night sleep phenotypes; BRCA cis rs4719841 0.662 rs9639523 chr7:25991977 A/C cg24254488 chr7:25991654 NA 0.29 8.88 0.33 6.46e-18 Triglyceride levels; BRCA cis rs9309711 0.961 rs11890651 chr2:3482796 T/G cg16153549 chr2:3496821 NA -0.38 -9.02 -0.34 2.09e-18 Neurofibrillary tangles; BRCA trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg13010199 chr12:38710504 ALG10B 0.52 9.89 0.36 1.5e-21 Morning vs. evening chronotype; BRCA cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.73 -0.33 2.29e-17 Colorectal cancer; BRCA cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg02466173 chr16:30829666 NA -0.54 -11.73 -0.42 6.71e-29 Multiple myeloma; BRCA cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg04450456 chr4:17643702 FAM184B 0.37 10.95 0.4 1.08e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs853679 0.607 rs13211507 chr6:28257377 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -8.75 -0.33 1.83e-17 Depression; BRCA cis rs3125734 0.633 rs1368157 chr10:64001114 T/C cg09941381 chr10:64027924 RTKN2 -0.27 -7.92 -0.3 1.07e-14 Rheumatoid arthritis; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.33 -0.54 2.28e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs760805 1.000 rs4648884 chr1:25261386 C/T cg22509179 chr1:25234806 RUNX3 0.56 14.34 0.49 1.17e-40 Allergic disease (asthma, hay fever or eczema); BRCA trans rs9291683 0.530 rs4697698 chr4:9942577 C/T cg26043149 chr18:55253948 FECH 0.4 8.94 0.33 3.99e-18 Bone mineral density; BRCA cis rs8180040 0.967 rs4858890 chr3:47405456 A/G cg27129171 chr3:47204927 SETD2 -0.66 -15.28 -0.52 3.55e-45 Colorectal cancer; BRCA cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg07395648 chr5:131743802 NA -0.36 -9.08 -0.34 1.32e-18 Blood metabolite levels; BRCA cis rs17092148 0.945 rs6142237 chr20:33340993 C/T cg16810054 chr20:33298113 TP53INP2 -0.5 -11.31 -0.41 3.81e-27 Neuroticism; BRCA cis rs2425143 1.000 rs10485510 chr20:34445164 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.54 -0.32 9.92e-17 Blood protein levels; BRCA cis rs16866061 0.855 rs11687736 chr2:225405122 A/T cg12698349 chr2:225449008 CUL3 0.78 21.23 0.64 4.04e-76 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg03605463 chr16:89740564 NA 0.41 8.65 0.32 4e-17 Vitiligo; BRCA cis rs4665809 1.000 rs11126340 chr2:26253255 A/G cg26314531 chr2:26401878 FAM59B -0.63 -10.48 -0.38 7.95e-24 Gut microbiome composition (summer); BRCA cis rs11696845 0.626 rs1111032 chr20:43378770 A/G cg25301532 chr20:43378953 KCNK15 0.45 10.77 0.39 5.61e-25 Obesity-related traits; BRCA trans rs11098499 0.863 rs1383532 chr4:120434404 A/T cg25214090 chr10:38739885 LOC399744 -0.54 -11.96 -0.43 6.99e-30 Corneal astigmatism; BRCA cis rs9296092 0.560 rs9469500 chr6:33526196 C/T cg13560919 chr6:33536144 NA -0.85 -17.98 -0.58 8.28e-59 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7772486 0.875 rs2748502 chr6:146298239 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.56 0.5 1.11e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs1865760 0.929 rs1816546 chr6:25938252 C/T cg16482183 chr6:26056742 HIST1H1C 0.51 10.48 0.38 7.92e-24 Height; BRCA cis rs9399135 0.933 rs9389262 chr6:135376409 G/T cg24558204 chr6:135376177 HBS1L 0.46 12.42 0.44 7.32e-32 Red blood cell count; BRCA cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg15395560 chr15:45543142 SLC28A2 -0.3 -7.85 -0.3 1.79e-14 Uric acid levels; BRCA cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg17143192 chr8:8559678 CLDN23 -0.54 -10.32 -0.38 3.35e-23 Obesity-related traits; BRCA cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg23711669 chr6:146136114 FBXO30 -0.8 -19.34 -0.61 5.67e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg02475777 chr4:1388615 CRIPAK 0.67 12.98 0.46 2.34e-34 Longevity; BRCA trans rs9291683 0.588 rs2240721 chr4:10020564 G/A cg26043149 chr18:55253948 FECH 0.39 8.42 0.32 2.43e-16 Bone mineral density; BRCA cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg09184832 chr6:79620586 NA -0.48 -10.52 -0.38 5.72e-24 Intelligence (multi-trait analysis); BRCA cis rs10845606 0.781 rs7972866 chr12:12828320 C/T cg09462578 chr12:12878428 APOLD1 -0.43 -8.66 -0.32 3.79e-17 Systemic lupus erythematosus; BRCA cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg13010199 chr12:38710504 ALG10B 0.52 9.84 0.36 2.2e-21 Bladder cancer; BRCA cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg25019033 chr10:957182 NA -0.42 -8.03 -0.3 4.66e-15 Eosinophil percentage of granulocytes; BRCA cis rs9309711 0.922 rs11679058 chr2:3483813 C/G cg16153549 chr2:3496821 NA -0.41 -9.47 -0.35 5.32e-20 Neurofibrillary tangles; BRCA cis rs4642101 0.793 rs13086170 chr3:12832604 G/C cg24848339 chr3:12840334 CAND2 0.43 11.51 0.41 5.55e-28 QRS complex (12-leadsum); BRCA trans rs587242 0.868 rs35869184 chr1:97027749 G/C cg10631902 chr5:14652156 NA 0.35 8.11 0.31 2.63e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs10992471 0.756 rs2516568 chr9:95187380 A/T cg14631576 chr9:95140430 CENPP -0.35 -8.43 -0.32 2.23e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs72772090 0.710 rs17400685 chr5:96066366 A/C cg24982541 chr5:96078678 CAST 0.46 7.99 0.3 6.19e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg13010199 chr12:38710504 ALG10B 0.41 8.37 0.31 3.59e-16 Bladder cancer; BRCA cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg11833968 chr6:79620685 NA -0.43 -9.67 -0.36 9.64e-21 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.05 -22.15 -0.66 4.01e-81 Gut microbiome composition (summer); BRCA cis rs12612619 0.732 rs11679681 chr2:27298479 C/A cg00617064 chr2:27272375 NA -0.32 -8.31 -0.31 5.86e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs16854884 0.632 rs62267390 chr3:143644067 A/T cg06585982 chr3:143692056 C3orf58 0.43 8.63 0.32 4.74e-17 Economic and political preferences (feminism/equality); BRCA trans rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05039488 chr6:79577232 IRAK1BP1 0.48 11.18 0.4 1.26e-26 Brugada syndrome; BRCA cis rs2832077 0.943 rs2832091 chr21:30162855 C/T cg24692254 chr21:30365293 RNF160 -0.48 -8.42 -0.32 2.52e-16 Cognitive test performance; BRCA cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.67 0.45 5.84e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3125734 0.633 rs7100297 chr10:63985100 T/C cg09941381 chr10:64027924 RTKN2 -0.27 -8.05 -0.3 4.11e-15 Rheumatoid arthritis; BRCA cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg09184832 chr6:79620586 NA -0.48 -10.71 -0.39 1.01e-24 Intelligence (multi-trait analysis); BRCA cis rs2070488 1.000 rs2070488 chr3:38442490 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -19.61 -0.61 2.23e-67 Electrocardiographic conduction measures; BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg27170947 chr2:26402098 FAM59B -0.91 -17.39 -0.57 9.91e-56 Gut microbiome composition (summer); BRCA trans rs3857536 0.813 rs62415859 chr6:66934278 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.12 -0.31 2.43e-15 Blood trace element (Cu levels); BRCA cis rs2422052 0.527 rs2276695 chr2:118814868 A/G cg22545206 chr2:118617499 NA 0.33 7.99 0.3 6.24e-15 Mosquito bite size; BRCA trans rs7824557 0.806 rs6601574 chr8:11094885 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -9.39 -0.35 1.04e-19 Retinal vascular caliber; BRCA cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.45e-19 Bipolar disorder; BRCA cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg18016565 chr1:150552671 MCL1 0.34 8.01 0.3 5.32e-15 Tonsillectomy; BRCA trans rs2204008 0.805 rs10881112 chr12:37956611 G/A cg06521331 chr12:34319734 NA 0.45 8.96 0.33 3.57e-18 Bladder cancer; BRCA cis rs9486715 0.867 rs2223238 chr6:96871855 G/A cg06623918 chr6:96969491 KIAA0776 0.9 25.35 0.71 1.22e-98 Headache; BRCA cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.03 0.49 3.57e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4690686 0.509 rs11730559 chr4:177259257 A/T cg17059388 chr4:177262070 NA 0.49 9.94 0.37 9.88e-22 Essential tremor; BRCA cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg16339924 chr4:17578868 LAP3 0.61 14.95 0.51 1.49e-43 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10463316 0.894 rs13361298 chr5:150765549 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.29 -0.31 6.58e-16 Metabolite levels (Pyroglutamine); BRCA cis rs7246657 0.943 rs2126977 chr19:37995747 C/G cg18154014 chr19:37997991 ZNF793 -0.53 -10.45 -0.38 1.03e-23 Coronary artery calcification; BRCA cis rs7394190 0.748 rs4746146 chr10:75527197 C/T cg07699608 chr10:75541558 CHCHD1 0.66 9.81 0.36 3.03e-21 Incident atrial fibrillation; BRCA cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.98 14.38 0.49 8.11e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6429082 0.783 rs291364 chr1:235687179 A/G cg26050004 chr1:235667680 B3GALNT2 0.55 14.41 0.5 5.73e-41 Adiposity; BRCA trans rs877282 0.945 rs10904556 chr10:789429 A/G cg22713356 chr15:30763199 NA 1.36 27.31 0.73 2.1e-109 Uric acid levels; BRCA cis rs1003719 0.715 rs13046581 chr21:38551985 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg19346786 chr7:2764209 NA 0.38 11.37 0.41 2.1e-27 Height; BRCA cis rs2016266 0.819 rs1976938 chr12:53661925 C/T cg26875137 chr12:53738046 NA 0.38 9.73 0.36 5.87e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs7301826 0.651 rs7132657 chr12:131285187 T/C cg11011512 chr12:131303247 STX2 0.52 13.58 0.47 4.57e-37 Plasma plasminogen activator levels; BRCA cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 0.32 7.86 0.3 1.59e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7927592 0.731 rs643609 chr11:68241833 A/G cg01657329 chr11:68192670 LRP5 -0.34 -8.04 -0.3 4.43e-15 Total body bone mineral density; BRCA cis rs13040088 0.935 rs3787513 chr20:61573736 G/A cg23096297 chr20:61557774 DIDO1 0.9 17.35 0.57 1.54e-55 Menopause (age at onset); BRCA cis rs9527 0.544 rs3781280 chr10:104863843 T/G cg04362960 chr10:104952993 NT5C2 0.47 10.77 0.39 5.66e-25 Arsenic metabolism; BRCA trans rs1962073 0.528 rs9329223 chr8:10331754 C/T cg15556689 chr8:8085844 FLJ10661 -0.3 -7.85 -0.3 1.82e-14 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); BRCA cis rs9487051 0.735 rs351754 chr6:109537553 A/G cg01475377 chr6:109611718 NA 0.47 11.78 0.42 3.95e-29 Reticulocyte fraction of red cells; BRCA cis rs9503598 0.714 rs11242859 chr6:3454032 G/A cg00476032 chr6:3446245 SLC22A23 0.42 10.75 0.39 7.03e-25 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 17.05 0.56 5.17e-54 Alzheimer's disease; BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.45 8.98 0.33 2.9e-18 Tonsillectomy; BRCA trans rs7181230 1.000 rs9972424 chr15:40365851 A/G cg22705835 chr10:65332833 REEP3 -0.4 -9.69 -0.36 8.28e-21 Dehydroepiandrosterone sulphate levels; BRCA cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg00339695 chr16:24857497 SLC5A11 0.52 11.45 0.41 9.89e-28 Intelligence (multi-trait analysis); BRCA cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.3 -0.35 2.15e-19 Intelligence (multi-trait analysis); BRCA cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg22563815 chr15:78856949 CHRNA5 -0.36 -8.62 -0.32 5.39e-17 Sudden cardiac arrest; BRCA cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg14196790 chr5:131705035 SLC22A5 0.39 9.52 0.35 3.55e-20 Breast cancer;Mosquito bite size; BRCA cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg22535103 chr8:58192502 C8orf71 -0.6 -12.91 -0.45 4.83e-34 Developmental language disorder (linguistic errors); BRCA cis rs12530845 0.673 rs73721607 chr7:135335822 C/T cg23117316 chr7:135346802 PL-5283 -0.39 -8.02 -0.3 5.07e-15 Red blood cell traits; BRCA cis rs3806843 1.000 rs4451093 chr5:140158542 A/G cg16179182 chr5:140090404 VTRNA1-1 0.4 9.43 0.35 7.36e-20 Depressive symptoms (multi-trait analysis); BRCA trans rs7824557 0.767 rs2060463 chr8:11161610 T/G cg08975724 chr8:8085496 FLJ10661 0.43 8.08 0.3 3.26e-15 Retinal vascular caliber; BRCA cis rs1953600 0.805 rs2819947 chr10:81947757 T/C cg04850286 chr10:81895943 PLAC9 0.31 9.1 0.34 1.14e-18 Sarcoidosis; BRCA cis rs12612619 0.704 rs2119026 chr2:27310393 A/G cg00617064 chr2:27272375 NA 0.34 8.81 0.33 1.14e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs523522 0.962 rs603574 chr12:120998443 A/G cg27279351 chr12:120934652 DYNLL1 0.56 13.32 0.47 7.04e-36 High light scatter reticulocyte count; BRCA cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg00108164 chr2:264199 ACP1;SH3YL1 0.71 13.94 0.48 9.16e-39 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg23018236 chr17:30244563 NA -0.69 -10.65 -0.39 1.73e-24 Hip circumference adjusted for BMI; BRCA cis rs2795502 1.000 rs2795508 chr10:43353555 G/T cg20628663 chr10:43360327 NA 0.68 13.71 0.48 1.12e-37 Blood protein levels; BRCA cis rs2131877 0.529 rs3892194 chr3:194855675 C/T cg13868855 chr3:194833887 C3orf21 -0.37 -8.62 -0.32 5.14e-17 Non-small cell lung cancer; BRCA cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg25072359 chr17:41440525 NA -0.43 -10.77 -0.39 5.84e-25 Menopause (age at onset); BRCA cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg14664628 chr15:75095509 CSK -0.52 -12.29 -0.44 2.54e-31 Breast cancer; BRCA cis rs10751667 0.643 rs10902245 chr11:953014 C/T cg06064525 chr11:970664 AP2A2 0.49 16.3 0.54 3.41e-50 Alzheimer's disease (late onset); BRCA cis rs870825 0.616 rs57271221 chr4:185627198 C/T cg04058563 chr4:185651563 MLF1IP 0.86 16.4 0.54 1.05e-50 Blood protein levels; BRCA cis rs11585357 0.947 rs2977303 chr1:17611548 A/T cg08277548 chr1:17600880 PADI3 -0.54 -10.21 -0.37 9.36e-23 Hair shape; BRCA trans rs66887589 0.934 rs56843000 chr4:120516597 T/C cg25214090 chr10:38739885 LOC399744 -0.35 -8.02 -0.3 5.21e-15 Diastolic blood pressure; BRCA cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.28 -8.16 -0.31 1.82e-15 Intelligence (multi-trait analysis); BRCA cis rs617791 0.569 rs11227370 chr11:65747693 C/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.47 8.69 0.32 3.16e-17 Breast cancer; BRCA cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg13902645 chr11:5959945 NA -0.52 -10.63 -0.39 2.14e-24 DNA methylation (variation); BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.78 0.62 2.7e-68 Platelet count; BRCA cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg03433033 chr1:76189801 ACADM 0.85 21.95 0.66 5.26e-80 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg11693508 chr17:37793320 STARD3 0.68 12.45 0.44 5.1e-32 Bipolar disorder; BRCA cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.32 10.12 0.37 2.06e-22 Bipolar disorder; BRCA cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg11062466 chr8:58055876 NA 0.41 7.88 0.3 1.38e-14 Developmental language disorder (linguistic errors); BRCA cis rs6060717 0.654 rs6060686 chr20:34512606 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -12.78 -0.45 1.75e-33 Hip circumference adjusted for BMI; BRCA cis rs733175 0.855 rs9291641 chr4:10007259 C/T cg00071950 chr4:10020882 SLC2A9 0.42 8.68 0.32 3.26e-17 Psychosis and Alzheimer's disease; BRCA cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg10792982 chr14:105748885 BRF1 0.47 11.08 0.4 3.2e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.31 0.41 3.75e-27 Rheumatoid arthritis; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.84 -14.16 -0.49 8.39e-40 Alzheimer's disease; BRCA cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg08923669 chr16:420230 MRPL28 -0.39 -9.41 -0.35 8.82e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.51 0.32 1.22e-16 Rheumatoid arthritis; BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg00814883 chr7:100076585 TSC22D4 -0.51 -11.67 -0.42 1.12e-28 Platelet count; BRCA cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg05347473 chr6:146136440 FBXO30 0.39 7.92 0.3 1.08e-14 Lobe attachment (rater-scored or self-reported); BRCA trans rs1493916 0.837 rs4997493 chr18:31407302 C/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.48 -0.32 1.55e-16 Life satisfaction; BRCA trans rs1459104 0.641 rs12790762 chr11:54933709 T/A cg15704280 chr7:45808275 SEPT13 0.58 8.04 0.3 4.29e-15 Body mass index; BRCA cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg21951975 chr1:209979733 IRF6 -0.4 -9.3 -0.35 2.28e-19 Cleft lip with or without cleft palate; BRCA cis rs1691799 0.899 rs1168295 chr12:66734151 G/C cg16791601 chr12:66731901 HELB -0.65 -17.59 -0.57 9.35e-57 White blood cell count (basophil); BRCA cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg05896524 chr21:47604654 C21orf56 -0.49 -9.66 -0.36 1.07e-20 Testicular germ cell tumor; BRCA cis rs67460515 0.563 rs6772723 chr3:160895074 C/G cg03342759 chr3:160939853 NMD3 -0.69 -14.38 -0.49 8.11e-41 Parkinson's disease; BRCA cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg03808351 chr9:123631620 PHF19 0.4 7.85 0.3 1.7e-14 Rheumatoid arthritis; BRCA cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg14844989 chr11:31128820 NA 0.46 9.91 0.36 1.27e-21 Red blood cell count; BRCA cis rs698833 0.886 rs2053455 chr2:44550233 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.88 0.4 2.12e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.67 0.36 1.02e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8017423 0.647 rs11626821 chr14:90824945 A/G cg04374321 chr14:90722782 PSMC1 -0.49 -11.75 -0.42 5.33e-29 Mortality in heart failure; BRCA cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 7.97 0.3 7.23e-15 Personality dimensions; BRCA cis rs11608355 0.545 rs35422737 chr12:109911456 A/G cg05360138 chr12:110035743 NA 0.71 13.05 0.46 1.09e-34 Neuroticism; BRCA cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg00409905 chr10:38381863 ZNF37A -0.53 -11.43 -0.41 1.22e-27 Extrinsic epigenetic age acceleration; BRCA cis rs6740322 0.748 rs6755601 chr2:43483044 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.74 -14.33 -0.49 1.43e-40 Coronary artery disease; BRCA cis rs7246657 0.943 rs1382357 chr19:37977609 G/A cg14683738 chr19:37701593 ZNF585B 0.45 8.07 0.3 3.58e-15 Coronary artery calcification; BRCA cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg21770322 chr7:97807741 LMTK2 0.41 11.08 0.4 3.09e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.51 -0.35 3.7799999999999997e-20 Total body bone mineral density; BRCA cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -13.76 -0.48 6.27e-38 Hemoglobin concentration; BRCA cis rs3784262 0.528 rs10518961 chr15:58334345 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.67 -0.36 9.65e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.91 0.33 5.1e-18 Platelet count; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg13397359 chr6:42928475 GNMT 0.76 19.39 0.61 3.43e-66 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs11098499 0.691 rs9307471 chr4:120261262 G/A cg25214090 chr10:38739885 LOC399744 0.42 9.85 0.36 2.11e-21 Corneal astigmatism; BRCA cis rs6570726 0.905 rs419575 chr6:145840174 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs867371 1.000 rs7173339 chr15:82467594 A/G cg00614314 chr15:82944287 LOC80154 0.43 8.92 0.33 4.89e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA trans rs8073060 0.586 rs7214742 chr17:33981969 C/A cg19694781 chr19:47549865 TMEM160 -1.05 -22.03 -0.66 1.81e-80 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1577917 0.958 rs1337843 chr6:86675545 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.26 -0.41 5.73e-27 Response to antipsychotic treatment; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg24060327 chr5:131705240 SLC22A5 -0.46 -9.15 -0.34 7.57e-19 Acylcarnitine levels; BRCA cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg26031613 chr14:104095156 KLC1 0.99 26.2 0.72 2.57e-103 Body mass index; BRCA cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11890956 chr21:40555474 PSMG1 -0.53 -10.92 -0.4 1.43e-25 Menarche (age at onset); BRCA cis rs858239 0.539 rs6975852 chr7:23186654 T/C cg23682824 chr7:23144976 KLHL7 0.37 9.5 0.35 4.11e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs877282 0.891 rs11595385 chr10:800539 A/G cg17470449 chr10:769945 NA 0.49 8.41 0.32 2.62e-16 Uric acid levels; BRCA cis rs3845702 1.000 rs9989852 chr2:180839707 G/A cg01881094 chr2:180872142 CWC22 -0.69 -13.7 -0.48 1.18e-37 Schizophrenia; BRCA cis rs6430585 0.583 rs79633114 chr2:136586825 C/T cg07169764 chr2:136633963 MCM6 1.29 28.7 0.75 5.33e-117 Corneal structure; BRCA cis rs9309711 0.737 rs9284795 chr2:3492065 G/A cg10845886 chr2:3471009 TTC15 -0.69 -14.1 -0.49 1.7e-39 Neurofibrillary tangles; BRCA cis rs1865721 0.755 rs3213875 chr18:73184048 C/T cg26385618 chr18:73139727 C18orf62 -0.33 -8.57 -0.32 7.55e-17 Intelligence; BRCA cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg06238570 chr21:40685208 BRWD1 -0.42 -8.65 -0.32 4.03e-17 Cognitive function; BRCA cis rs3762637 0.943 rs72960447 chr3:122235105 G/A cg24169773 chr3:122142474 KPNA1 -0.43 -8.01 -0.3 5.54e-15 LDL cholesterol levels; BRCA cis rs7520050 0.743 rs61789988 chr1:46085242 G/C cg24296786 chr1:45957014 TESK2 0.46 10.59 0.39 3.09e-24 Red blood cell count;Reticulocyte count; BRCA cis rs17270561 0.609 rs4145217 chr6:25743997 T/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA trans rs4689592 0.622 rs2276968 chr4:7070118 T/G cg07817883 chr1:32538562 TMEM39B -0.44 -7.97 -0.3 7.27e-15 Monocyte percentage of white cells; BRCA cis rs208515 0.556 rs12206707 chr6:66697182 A/G cg07460842 chr6:66804631 NA 0.87 15.52 0.52 2.4e-46 Exhaled nitric oxide levels; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg12444411 chr7:2802554 GNA12 -0.35 -8.66 -0.32 3.82e-17 Height; BRCA trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg20290983 chr6:43655470 MRPS18A -1.09 -38.37 -0.84 5.86e-168 IgG glycosylation; BRCA cis rs6028335 0.674 rs66486072 chr20:37647882 G/A cg16355469 chr20:37678765 NA 0.51 9.61 0.36 1.58e-20 Alcohol and nicotine co-dependence; BRCA cis rs72781680 0.716 rs2551325 chr2:23979729 C/T cg08917208 chr2:24149416 ATAD2B 0.64 10.14 0.37 1.68e-22 Lymphocyte counts; BRCA cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg05025164 chr4:1340916 KIAA1530 0.48 10.6 0.39 2.8e-24 Longevity; BRCA cis rs34779708 0.931 rs34815241 chr10:35296676 T/C cg03585969 chr10:35415529 CREM 0.49 10.21 0.37 9.07e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg00484396 chr16:3507460 NAT15 -0.46 -9.79 -0.36 3.59e-21 Tuberculosis; BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg04944784 chr2:26401820 FAM59B -0.95 -16.46 -0.55 5.26e-51 Gut microbiome composition (summer); BRCA cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg22875332 chr1:76189707 ACADM 0.62 11.48 0.41 7.45e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs13082711 0.595 rs34453788 chr3:27330153 T/C cg02860705 chr3:27208620 NA 0.74 13.43 0.47 2.13e-36 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs3784262 0.669 rs7171261 chr15:58356855 C/G cg12031962 chr15:58353849 ALDH1A2 0.37 10.03 0.37 4.3e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1975991 0.538 rs12629150 chr3:187963329 C/A cg15417654 chr3:187959138 LPP 0.35 8.94 0.33 4.12e-18 White matter integrity (bipolar disorder risk interaction); BRCA trans rs7944735 0.507 rs10742827 chr11:48102350 C/T cg15704280 chr7:45808275 SEPT13 0.43 7.98 0.3 6.55e-15 Intraocular pressure; BRCA cis rs2070488 1.000 rs13074025 chr3:38455704 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.55 0.61 4.35e-67 Electrocardiographic conduction measures; BRCA cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg13256891 chr4:100009986 ADH5 0.47 9.06 0.34 1.52e-18 Alcohol dependence; BRCA cis rs312274 0.546 rs7295964 chr12:41272564 T/C cg17827154 chr12:41323612 CNTN1 -0.36 -8.98 -0.33 3.03e-18 Metabolite levels (X-11787); BRCA cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg06552810 chr11:31128660 NA -0.39 -8.76 -0.33 1.8e-17 Red blood cell count; BRCA cis rs2243480 1.000 rs10807701 chr7:65724686 C/A cg18252515 chr7:66147081 NA 1.04 15.72 0.53 2.58e-47 Diabetic kidney disease; BRCA cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -9.61 -0.36 1.61e-20 Response to bleomycin (chromatid breaks); BRCA cis rs4588572 0.643 rs1019739 chr5:77770241 G/C cg11547950 chr5:77652471 NA -0.48 -8.53 -0.32 1.08e-16 Triglycerides; BRCA cis rs7631605 0.905 rs6773752 chr3:37225837 C/T cg15934958 chr3:37212084 LRRFIP2 0.42 9.85 0.36 2.03e-21 Cerebrospinal P-tau181p levels; BRCA cis rs7927592 0.956 rs10896337 chr11:68284236 T/C cg20283391 chr11:68216788 NA -0.45 -9.04 -0.34 1.81e-18 Total body bone mineral density; BRCA cis rs13272623 0.502 rs268628 chr8:71560505 T/C cg23757474 chr8:71581111 LACTB2;XKR9 -0.51 -10.91 -0.4 1.58e-25 IgG glycosylation; BRCA cis rs6089584 0.830 rs6089309 chr20:60585687 T/C cg06108461 chr20:60628389 TAF4 -0.84 -17.72 -0.57 1.8e-57 Body mass index; BRCA cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg26597838 chr10:835615 NA 1.01 15.56 0.52 1.59e-46 Eosinophil percentage of granulocytes; BRCA cis rs7851660 0.967 rs4743135 chr9:100599493 C/T cg13688889 chr9:100608707 NA -0.36 -8.61 -0.32 5.84e-17 Strep throat; BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg24549020 chr5:56110836 MAP3K1 0.67 13.31 0.47 7.36e-36 Initial pursuit acceleration; BRCA cis rs12541635 0.677 rs2029880 chr8:107024649 T/C cg10147462 chr8:107024639 NA 0.39 10.73 0.39 8.37e-25 Age of smoking initiation; BRCA cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.23 0.38 7.64e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs8017423 0.967 rs11628812 chr14:90713720 G/T cg04374321 chr14:90722782 PSMC1 -0.76 -21.46 -0.65 2.43e-77 Mortality in heart failure; BRCA cis rs2289583 0.517 rs2004278 chr15:75264363 C/T cg10253484 chr15:75165896 SCAMP2 0.47 8.53 0.32 1.02e-16 Systemic lupus erythematosus; BRCA cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -13.71 -0.48 1.09e-37 Hemoglobin concentration; BRCA trans rs7824557 0.767 rs3808509 chr8:11163256 G/T cg08975724 chr8:8085496 FLJ10661 0.44 8.11 0.31 2.58e-15 Retinal vascular caliber; BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg14863265 chr7:2801509 GNA12 -0.51 -11.17 -0.4 1.34e-26 Height; BRCA cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.13 0.4 2.01e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs597583 0.775 rs12806865 chr11:117404769 C/T cg27161313 chr11:117392002 DSCAML1 0.37 7.86 0.3 1.7e-14 Putamen volume; BRCA cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg23711669 chr6:146136114 FBXO30 -0.76 -17.6 -0.57 8.28e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs2953145 0.568 rs1133354 chr2:241522450 A/G cg07929629 chr2:241523174 NA 0.54 11.9 0.43 1.18e-29 Bipolar disorder; BRCA cis rs829883 0.966 rs249818 chr12:98896994 A/C cg25150519 chr12:98850993 NA 0.59 11.9 0.43 1.19e-29 Colorectal adenoma (advanced); BRCA cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg17971929 chr21:40555470 PSMG1 0.76 16.59 0.55 1.12e-51 Cognitive function; BRCA cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.16 -0.34 6.79e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg23131131 chr22:24373011 LOC391322 0.45 9.56 0.35 2.59e-20 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs11585357 0.895 rs112208664 chr1:17632010 G/A cg08277548 chr1:17600880 PADI3 -0.69 -11.78 -0.42 3.86e-29 Hair shape; BRCA cis rs8072100 0.817 rs9892497 chr17:45545919 G/A cg25173405 chr17:45401733 C17orf57 -0.54 -11.7 -0.42 8.9e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs7582180 0.629 rs36103184 chr2:100942634 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.67 0.42 1.21e-28 Intelligence (multi-trait analysis); BRCA cis rs9309473 0.607 rs10198301 chr2:73581600 T/A cg20560298 chr2:73613845 ALMS1 -0.42 -10.93 -0.4 1.31e-25 Metabolite levels; BRCA cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg04455712 chr21:45112962 RRP1B 0.4 10.28 0.38 4.82e-23 Mean corpuscular volume; BRCA cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg00071950 chr4:10020882 SLC2A9 -0.42 -9.81 -0.36 3.04e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg26769984 chr7:1090371 C7orf50 0.64 11.29 0.41 4.46e-27 Bronchopulmonary dysplasia; BRCA cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg05896524 chr21:47604654 C21orf56 0.48 9.9 0.36 1.41e-21 Testicular germ cell tumor; BRCA cis rs17641971 0.684 rs4873310 chr8:49990006 A/T cg00325661 chr8:49890786 NA 0.39 10.81 0.39 4.14e-25 Blood metabolite levels; BRCA cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg08917208 chr2:24149416 ATAD2B 0.52 8.0 0.3 5.99e-15 Lymphocyte counts; BRCA trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg12193833 chr17:30244370 NA -0.54 -8.72 -0.33 2.35e-17 Hip circumference adjusted for BMI; BRCA cis rs8180040 0.654 rs1466740 chr3:47245883 C/T cg27129171 chr3:47204927 SETD2 -0.71 -17.25 -0.56 4.72e-55 Colorectal cancer; BRCA cis rs10845606 1.000 rs10845606 chr12:12834894 G/T cg04607235 chr12:12878440 APOLD1 -0.66 -10.54 -0.38 4.76e-24 Systemic lupus erythematosus; BRCA cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg02659138 chr7:134003124 SLC35B4 0.31 9.56 0.35 2.49e-20 Mean platelet volume; BRCA cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg08999081 chr20:33150536 PIGU 0.5 14.19 0.49 6.64e-40 Coronary artery disease; BRCA cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg04455712 chr21:45112962 RRP1B 0.4 10.7 0.39 1.05e-24 Mean corpuscular volume; BRCA cis rs7568458 0.709 rs1446669 chr2:85762209 T/C cg02493740 chr2:85810744 VAMP5 -0.51 -10.48 -0.38 7.97e-24 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg18876405 chr7:65276391 NA 0.56 13.5 0.47 1.02e-36 Aortic root size; BRCA cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.64 -0.32 4.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8005677 0.611 rs11624528 chr14:23459156 A/G cg01529538 chr14:23388837 RBM23 0.37 9.03 0.34 1.99e-18 Cognitive ability (multi-trait analysis); BRCA cis rs4409675 0.576 rs6703851 chr1:28237556 G/A cg23691781 chr1:28212827 C1orf38 0.31 9.92 0.37 1.12e-21 Corneal astigmatism; BRCA cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg03934865 chr2:198174659 NA -0.39 -8.4 -0.32 2.96e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs11098499 0.698 rs4422403 chr4:120258194 C/T cg09307838 chr4:120376055 NA 0.59 12.85 0.45 8.72e-34 Corneal astigmatism; BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg22920501 chr2:26401640 FAM59B -0.72 -12.4 -0.44 8.2e-32 Gut microbiome composition (summer); BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg04727924 chr7:799746 HEATR2 -0.51 -8.86 -0.33 7.84e-18 Cerebrospinal P-tau181p levels; BRCA cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg10523679 chr1:76189770 ACADM -0.49 -9.58 -0.35 2.09e-20 Daytime sleep phenotypes; BRCA cis rs1018836 0.884 rs7008765 chr8:91632589 C/T cg16814680 chr8:91681699 NA -0.61 -12.96 -0.46 2.82e-34 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.39 9.42 0.35 7.89e-20 Alzheimer's disease (late onset); BRCA cis rs999943 0.846 rs10947422 chr6:33611351 G/A cg14003231 chr6:33640908 ITPR3 0.62 14.08 0.49 2.06e-39 Obesity (extreme); BRCA cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg13010199 chr12:38710504 ALG10B 0.56 12.33 0.44 1.71e-31 Heart rate; BRCA cis rs7520050 0.966 rs4134386 chr1:46395089 G/A cg24296786 chr1:45957014 TESK2 0.44 9.8 0.36 3.19e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg25427524 chr10:38739819 LOC399744 0.7 15.63 0.53 7.03e-47 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6546550 0.901 rs34586537 chr2:70163316 G/T cg02498382 chr2:70120550 SNRNP27 0.52 11.18 0.4 1.21e-26 Prevalent atrial fibrillation; BRCA cis rs666930 0.519 rs662602 chr1:120266903 C/G cg19096424 chr1:120255104 PHGDH 0.63 13.7 0.48 1.16e-37 Breast cancer; BRCA cis rs78456975 0.574 rs13412980 chr2:1545231 C/A cg26248373 chr2:1572462 NA -0.54 -10.6 -0.39 2.6e-24 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg05347473 chr6:146136440 FBXO30 0.4 8.28 0.31 7.34e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7394190 0.748 rs11000766 chr10:75512952 C/T cg07699608 chr10:75541558 CHCHD1 0.66 9.85 0.36 2.01e-21 Incident atrial fibrillation; BRCA cis rs9467773 0.620 rs2494692 chr6:26615223 G/A cg09904177 chr6:26538194 HMGN4 0.47 14.88 0.51 3.21e-43 Intelligence (multi-trait analysis); BRCA cis rs73086581 1.000 rs6107391 chr20:3983083 A/G cg02187196 chr20:3869020 PANK2 0.5 9.1 0.34 1.11e-18 Response to antidepressants in depression; BRCA cis rs595982 0.559 rs117227130 chr19:49367959 A/G cg15549821 chr19:49342101 PLEKHA4 -0.7 -11.51 -0.41 5.66e-28 Red cell distribution width; BRCA cis rs2274273 0.840 rs66486619 chr14:55869555 T/G cg04306507 chr14:55594613 LGALS3 0.31 8.65 0.32 4e-17 Protein biomarker; BRCA cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.61 0.32 5.6e-17 Rheumatoid arthritis; BRCA cis rs12348691 0.503 rs907576 chr9:100615359 C/T cg13688889 chr9:100608707 NA -0.49 -9.9 -0.36 1.32e-21 Alopecia areata; BRCA cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.08 0.4 3.27e-26 Bipolar disorder; BRCA cis rs9420 0.961 rs527528 chr11:57433327 C/T cg19752551 chr11:57585705 CTNND1 -0.41 -10.51 -0.38 6.25e-24 Schizophrenia; BRCA cis rs3772130 0.540 rs11717089 chr3:121563271 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.39 0.49 7.2e-41 Cognitive performance; BRCA cis rs6570726 0.935 rs449377 chr6:145852437 C/G cg23711669 chr6:146136114 FBXO30 0.64 15.12 0.51 2.12e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.01 0.34 2.27e-18 Motion sickness; BRCA cis rs72634258 0.945 rs12745223 chr1:8094978 C/T cg00042356 chr1:8021962 PARK7 0.77 11.81 0.42 2.89e-29 Inflammatory bowel disease; BRCA cis rs9469890 0.604 rs11758471 chr6:34503517 A/C cg14254433 chr6:34482411 PACSIN1 -0.44 -9.07 -0.34 1.44e-18 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.38 -0.35 1.09e-19 Menopause (age at onset); BRCA cis rs9341808 0.754 rs9343973 chr6:80913216 A/G cg08355045 chr6:80787529 NA 0.39 9.95 0.37 8.62e-22 Sitting height ratio; BRCA cis rs6121246 0.609 rs6060948 chr20:30376393 C/G cg13852791 chr20:30311386 BCL2L1 0.84 18.15 0.58 1.15e-59 Mean corpuscular hemoglobin; BRCA cis rs7267979 1.000 rs6050562 chr20:25336186 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.11 -0.34 1.06e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9858542 0.953 rs9818590 chr3:49525096 A/G cg03060546 chr3:49711283 APEH -0.54 -10.99 -0.4 7.38e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA cis rs9649465 1.000 rs13225220 chr7:123371026 C/A cg04330084 chr7:123175371 IQUB -0.33 -8.98 -0.33 2.94e-18 Migraine; BRCA cis rs7772486 0.875 rs10457792 chr6:146412415 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.73 -0.33 2.24e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs870825 0.616 rs12512839 chr4:185610347 G/A cg20176042 chr4:185552304 CASP3 -0.54 -8.18 -0.31 1.57e-15 Blood protein levels; BRCA trans rs61931739 0.824 rs406753 chr12:34117408 A/G cg26384229 chr12:38710491 ALG10B 0.44 10.54 0.38 4.79e-24 Morning vs. evening chronotype; BRCA cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg24130564 chr14:104152367 KLC1 -0.34 -7.92 -0.3 1.09e-14 Body mass index; BRCA cis rs55883249 1.000 rs56372340 chr2:9741536 A/G cg23886495 chr2:9695866 ADAM17 0.55 7.95 0.3 8.63e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs7523273 0.606 rs2488253 chr1:207938709 C/A cg22525895 chr1:207977042 MIR29B2 0.48 12.16 0.43 9.54e-31 Schizophrenia; BRCA trans rs11098499 0.731 rs9995026 chr4:120490499 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.16 0.31 1.73e-15 Corneal astigmatism; BRCA cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg07606381 chr6:8435919 SLC35B3 0.64 13.93 0.48 1.08e-38 Motion sickness; BRCA cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg21854759 chr1:92012499 NA -0.39 -9.36 -0.35 1.3e-19 Breast cancer; BRCA cis rs11677370 0.561 rs12711973 chr2:3825339 C/G cg17052675 chr2:3827356 NA -0.61 -15.78 -0.53 1.31e-47 Type 2 diabetes; BRCA cis rs1401999 0.650 rs3792585 chr3:183646222 A/G cg01324343 chr3:183735012 ABCC5 0.63 14.92 0.51 2e-43 Anterior chamber depth; BRCA trans rs7819412 0.595 rs10106914 chr8:10987651 T/G cg15556689 chr8:8085844 FLJ10661 -0.36 -9.51 -0.35 3.95e-20 Triglycerides; BRCA cis rs637571 0.522 rs556643 chr11:65733289 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.57 12.78 0.45 1.81e-33 Eosinophil percentage of white cells; BRCA cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -12.3 -0.44 2.39e-31 Personality dimensions; BRCA cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 8.42 0.32 2.57e-16 Renal function-related traits (BUN); BRCA cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg15556689 chr8:8085844 FLJ10661 0.36 9.92 0.37 1.11e-21 Mood instability; BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.8 -14.52 -0.5 1.73e-41 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7829975 0.573 rs7842359 chr8:8797078 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -11.75 -0.42 5.12e-29 Mood instability; BRCA cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg06671706 chr8:8559999 CLDN23 -0.43 -8.28 -0.31 7.08e-16 Obesity-related traits; BRCA cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg23711669 chr6:146136114 FBXO30 0.72 16.44 0.55 6.45e-51 Lobe attachment (rater-scored or self-reported); BRCA trans rs9291683 0.655 rs35750364 chr4:10049049 T/C cg26043149 chr18:55253948 FECH 0.42 9.14 0.34 8.24e-19 Bone mineral density; BRCA trans rs9944715 0.954 rs62096526 chr18:43745639 G/A cg01718231 chr17:29326311 RNF135 0.45 8.88 0.33 6.98e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs600806 0.888 rs3853501 chr1:109864374 G/A cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.5e-15 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg17971929 chr21:40555470 PSMG1 0.82 19.79 0.62 2.45e-68 Cognitive function; BRCA trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg03929089 chr4:120376271 NA -0.53 -8.81 -0.33 1.21e-17 Axial length; BRCA cis rs1468333 1.000 rs7729926 chr5:137514641 A/T cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.31 0.35 1.96e-19 Resting heart rate; BRCA trans rs7178375 1.000 rs10163148 chr15:31212684 C/G cg04373760 chr16:53404718 NA 0.46 8.7 0.33 2.77e-17 Hypertriglyceridemia; BRCA cis rs17401966 0.898 rs11582123 chr1:10303942 A/T cg03954927 chr1:10346856 KIF1B 0.47 14.99 0.51 1e-43 Hepatocellular carcinoma; BRCA cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg12756686 chr19:29218302 NA 0.46 8.09 0.3 3.07e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg25206134 chr2:45395956 NA 0.54 8.75 0.33 1.87e-17 Bipolar disorder; BRCA cis rs9287719 0.781 rs12472807 chr2:10781605 G/A cg00105475 chr2:10696890 NA 0.41 9.53 0.35 3.17e-20 Prostate cancer; BRCA trans rs7746199 0.736 rs13209332 chr6:27520752 T/A cg06606381 chr12:133084897 FBRSL1 -0.87 -8.53 -0.32 1.1e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.33 -0.31 5.11e-16 Bipolar disorder; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg22907277 chr7:1156413 C7orf50 0.44 10.08 0.37 2.94e-22 Longevity;Endometriosis; BRCA cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.73e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6942756 0.668 rs644723 chr7:129107881 C/T cg02491457 chr7:128862824 NA -0.56 -11.38 -0.41 1.9e-27 White matter hyperintensity burden; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg08470875 chr2:26401718 FAM59B -0.66 -9.77 -0.36 4.27e-21 Gut microbiome composition (summer); BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg19723775 chr5:179050963 HNRNPH1 0.36 8.73 0.33 2.19e-17 Lung cancer; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00802000 chr16:706648 WDR90 -0.4 -9.36 -0.35 1.32e-19 Height; BRCA cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.63 -0.39 2.15e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs637571 0.522 rs542332 chr11:65744421 C/T cg17712092 chr4:129076599 LARP1B 0.54 13.22 0.46 1.83e-35 Eosinophil percentage of white cells; BRCA cis rs10504073 0.647 rs10435612 chr8:49993696 A/T cg00325661 chr8:49890786 NA 0.44 12.51 0.44 2.87e-32 Blood metabolite ratios; BRCA cis rs701145 0.585 rs7612886 chr3:153821176 T/A cg12800244 chr3:153838788 SGEF 0.63 7.87 0.3 1.47e-14 Coronary artery disease; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg06468780 chr21:31798236 KRTAP13-3 0.39 9.53 0.35 3.15e-20 HDL cholesterol; BRCA cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.74 17.63 0.57 5.68e-57 Chronic sinus infection; BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg25036284 chr2:26402008 FAM59B -0.88 -15.93 -0.53 2.26e-48 Gut microbiome composition (summer); BRCA cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg11168104 chr5:1857477 NA -0.35 -9.34 -0.35 1.5700000000000001e-19 Cardiovascular disease risk factors; BRCA cis rs1691799 0.867 rs1168342 chr12:66758734 A/T cg16791601 chr12:66731901 HELB -0.66 -18.01 -0.58 6.07e-59 White blood cell count (basophil); BRCA cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg18512352 chr11:47633146 NA 0.32 7.93 0.3 1e-14 Subjective well-being; BRCA cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg24088639 chr11:34937564 PDHX;APIP -0.43 -9.6 -0.36 1.76e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg09035930 chr12:129282057 SLC15A4 0.5 14.0 0.48 5e-39 Systemic lupus erythematosus; BRCA cis rs12618769 0.625 rs56232707 chr2:99032298 G/A cg10123293 chr2:99228465 UNC50 0.4 7.97 0.3 7.08e-15 Bipolar disorder; BRCA cis rs6545883 0.831 rs9309336 chr2:61763165 T/C cg15711740 chr2:61764176 XPO1 -0.55 -14.15 -0.49 9.2e-40 Tuberculosis; BRCA cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg06115741 chr20:33292138 TP53INP2 0.36 8.13 0.31 2.23e-15 Glomerular filtration rate (creatinine); BRCA cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.754 rs12711071 chr4:120240934 A/G cg25214090 chr10:38739885 LOC399744 0.44 10.23 0.38 7.5e-23 Corneal astigmatism; BRCA cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14019695 chr9:139328340 INPP5E -0.41 -11.25 -0.41 6.75e-27 Granulocyte percentage of myeloid white cells; BRCA cis rs9790314 0.521 rs1450522 chr3:161077630 A/G cg04691961 chr3:161091175 C3orf57 -0.37 -8.01 -0.3 5.35e-15 Morning vs. evening chronotype; BRCA cis rs7707921 0.881 rs324914 chr5:81389950 C/T cg15871215 chr5:81402204 ATG10 0.38 7.98 0.3 6.6e-15 Breast cancer; BRCA cis rs7520050 0.966 rs11810993 chr1:46478793 A/G cg24296786 chr1:45957014 TESK2 0.44 9.84 0.36 2.35e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2882667 0.690 rs11749163 chr5:138262670 A/G cg04439458 chr5:138467593 SIL1 -0.32 -8.02 -0.3 4.96e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs16944613 0.541 rs6496690 chr15:91097401 T/C cg26821196 chr15:91095069 CRTC3 0.47 8.12 0.31 2.46e-15 Colorectal cancer; BRCA cis rs262150 0.714 rs2657397 chr7:158785095 C/T cg19418458 chr7:158789849 NA -0.42 -9.41 -0.35 8.77e-20 Facial morphology (factor 20); BRCA cis rs2710642 0.888 rs2539985 chr2:63134507 T/A cg17519650 chr2:63277830 OTX1 0.36 7.97 0.3 7.51e-15 LDL cholesterol levels;LDL cholesterol; BRCA cis rs13427251 0.692 rs17765112 chr2:100149336 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.34 -7.85 -0.3 1.7e-14 Chronic sinus infection; BRCA cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg19717773 chr7:2847554 GNA12 -0.43 -9.54 -0.35 2.88e-20 Height; BRCA cis rs4787491 0.704 rs67218159 chr16:30050505 C/T cg06326092 chr16:30034487 C16orf92 0.38 9.92 0.37 1.16e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9399135 0.967 rs2297338 chr6:135375762 G/A cg24558204 chr6:135376177 HBS1L 0.46 12.41 0.44 7.89e-32 Red blood cell count; BRCA cis rs35306767 0.855 rs12770190 chr10:951262 C/T cg20503657 chr10:835505 NA 1.04 17.39 0.57 9.44e-56 Eosinophil percentage of granulocytes; BRCA cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg24531977 chr5:56204891 C5orf35 -0.42 -8.5 -0.32 1.35e-16 Coronary artery disease; BRCA cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.59 12.05 0.43 2.77e-30 Monocyte percentage of white cells; BRCA trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -16.76 -0.55 1.52e-52 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg26395211 chr5:140044315 WDR55 0.37 8.48 0.32 1.58e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs654950 0.783 rs639298 chr1:42001530 A/G cg06885757 chr1:42089581 HIVEP3 -0.24 -8.8 -0.33 1.23e-17 Airway imaging phenotypes; BRCA cis rs3750965 0.959 rs3376 chr11:68856680 G/A cg06818126 chr11:68850279 TPCN2 -0.36 -8.41 -0.32 2.65e-16 Hair color; BRCA cis rs2625529 0.818 rs2246225 chr15:72115230 C/T cg16672083 chr15:72433130 SENP8 0.71 14.79 0.5 9.16e-43 Red blood cell count; BRCA cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg08807101 chr21:30365312 RNF160 0.74 19.35 0.61 5.06e-66 Dental caries; BRCA cis rs9649465 1.000 rs2109725 chr7:123325459 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs1555322 0.530 rs2425047 chr20:33871675 G/T cg03689076 chr20:33865952 NA -0.43 -8.03 -0.3 4.63e-15 Attention deficit hyperactivity disorder; BRCA cis rs9858542 0.537 rs56038006 chr3:49362369 C/T cg00383909 chr3:49044727 WDR6 0.5 9.67 0.36 9.49e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs921968 0.541 rs593888 chr2:219427597 A/G cg10223061 chr2:219282414 VIL1 -0.27 -8.1 -0.31 2.77e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg00684032 chr4:1343700 KIAA1530 0.31 7.97 0.3 7.36e-15 Obesity-related traits; BRCA cis rs875971 0.660 rs801217 chr7:66010577 C/T cg11764359 chr7:65958608 NA -0.68 -15.19 -0.52 9.94e-45 Aortic root size; BRCA cis rs2073300 1.000 rs79255223 chr20:23443559 G/T cg12062639 chr20:23401060 NAPB 0.88 10.43 0.38 1.28e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4561483 0.734 rs33655 chr16:11970381 C/T cg08843971 chr16:11963173 GSPT1 -0.53 -11.97 -0.43 5.94e-30 Testicular germ cell tumor; BRCA cis rs4481887 1.000 rs4306162 chr1:248468509 C/T cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg15017067 chr4:17643749 FAM184B 0.28 8.53 0.32 1.04e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10838687 0.736 rs830083 chr11:47254051 G/C cg25783544 chr11:47291846 MADD -0.41 -7.89 -0.3 1.36e-14 Proinsulin levels; BRCA cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.54 -0.52 1.99e-46 Axial length; BRCA cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg17691542 chr6:26056736 HIST1H1C 0.56 11.84 0.42 2.28e-29 Height; BRCA trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -14.18 -0.49 7.04e-40 Extrinsic epigenetic age acceleration; BRCA cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg08564027 chr20:61660810 NA 0.85 22.56 0.67 2.3e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.45 -9.23 -0.34 3.8e-19 Tonsillectomy; BRCA trans rs61931739 0.534 rs11053021 chr12:34111157 C/T cg13010199 chr12:38710504 ALG10B 0.47 9.18 0.34 5.96e-19 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs2000351 chr6:25759783 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs7914558 1.000 rs10883837 chr10:104896486 G/A cg04362960 chr10:104952993 NT5C2 0.44 10.8 0.39 4.26e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg22307029 chr19:49891270 CCDC155 0.6 10.98 0.4 8.1e-26 Multiple sclerosis; BRCA cis rs17092148 0.887 rs932542 chr20:33171368 G/C cg16810054 chr20:33298113 TP53INP2 -0.47 -10.28 -0.38 5e-23 Neuroticism; BRCA cis rs4074536 0.574 rs10754347 chr1:116286818 C/A cg21648376 chr1:116311395 CASQ2 -0.49 -8.51 -0.32 1.27e-16 QRS duration; BRCA cis rs10782582 0.609 rs5745553 chr1:76379135 A/T cg03433033 chr1:76189801 ACADM -0.38 -7.92 -0.3 1.05e-14 Daytime sleep phenotypes; BRCA trans rs629535 0.679 rs62511660 chr8:70157089 G/A cg21567404 chr3:27674614 NA -0.96 -17.52 -0.57 2.09e-56 Dupuytren's disease; BRCA cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg06453172 chr10:134556979 INPP5A -0.5 -10.75 -0.39 7.16e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9359856 0.564 rs34732313 chr6:90368380 G/A cg13799429 chr6:90582589 CASP8AP2 -0.64 -8.54 -0.32 9.91e-17 Bipolar disorder; BRCA cis rs4588572 0.644 rs1428864 chr5:77780263 C/T cg11547950 chr5:77652471 NA -0.45 -8.64 -0.32 4.64e-17 Triglycerides; BRCA cis rs4642101 0.561 rs7638333 chr3:12806142 T/C cg24848339 chr3:12840334 CAND2 0.38 9.38 0.35 1.09e-19 QRS complex (12-leadsum); BRCA cis rs9811920 0.535 rs793481 chr3:99488742 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.86 -0.36 1.97e-21 Axial length; BRCA cis rs17818399 0.620 rs6739397 chr2:46858321 G/C cg02822958 chr2:46747628 ATP6V1E2 0.42 8.37 0.31 3.57e-16 Height; BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -11.85 -0.42 2e-29 Tonsillectomy; BRCA cis rs2455799 0.573 rs2455793 chr3:15743844 A/G cg16303742 chr3:15540471 COLQ -0.36 -8.68 -0.32 3.36e-17 Mean platelet volume; BRCA cis rs4363385 0.720 rs6672735 chr1:152981086 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.83 -0.36 2.47e-21 Inflammatory skin disease; BRCA cis rs7246657 0.653 rs10401525 chr19:37658979 C/G cg23950597 chr19:37808831 NA -0.64 -9.79 -0.36 3.55e-21 Coronary artery calcification; BRCA cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.14 0.4 1.9e-26 IgG glycosylation; BRCA cis rs13082711 0.871 rs35572617 chr3:27499247 A/T cg02860705 chr3:27208620 NA 0.59 11.08 0.4 3.26e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6545883 0.894 rs2593633 chr2:61571513 T/C cg15711740 chr2:61764176 XPO1 0.53 13.48 0.47 1.25e-36 Tuberculosis; BRCA cis rs943466 1.000 rs6930201 chr6:33738749 A/C cg25922239 chr6:33757077 LEMD2 -0.38 -8.38 -0.31 3.31e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg04607235 chr12:12878440 APOLD1 -0.65 -10.33 -0.38 3.05e-23 Systemic lupus erythematosus; BRCA cis rs760805 1.000 rs7517302 chr1:25254317 C/T cg22509179 chr1:25234806 RUNX3 -0.58 -14.81 -0.51 7.17e-43 Allergic disease (asthma, hay fever or eczema); BRCA cis rs9942416 0.592 rs10462521 chr5:74985867 T/C cg19683494 chr5:74908142 NA 0.48 9.0 0.34 2.58e-18 Age-related disease endophenotypes; BRCA cis rs9473147 0.516 rs9349415 chr6:47551861 T/C cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.92e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg14983838 chr19:29218262 NA -0.46 -7.81 -0.3 2.32e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg24110177 chr3:50126178 RBM5 0.52 14.7 0.5 2.43e-42 Body mass index; BRCA cis rs4478858 0.735 rs6687819 chr1:31801112 G/A cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.24 0.44 4.06e-31 Corneal astigmatism; BRCA cis rs2882667 0.690 rs10155636 chr5:138261990 A/G cg04439458 chr5:138467593 SIL1 -0.34 -8.22 -0.31 1.1e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg19077165 chr18:44547161 KATNAL2 0.39 8.45 0.32 1.95e-16 Personality dimensions; BRCA cis rs6987853 0.761 rs2974356 chr8:42434633 C/T cg09913449 chr8:42400586 C8orf40 0.42 9.29 0.35 2.33e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg23711669 chr6:146136114 FBXO30 0.79 18.81 0.6 3.83e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg01579765 chr21:45077557 HSF2BP 0.41 10.71 0.39 1.02e-24 Mean corpuscular volume; BRCA cis rs17253792 0.822 rs78522049 chr14:56071203 A/C cg24579896 chr14:56047964 C14orf33;KTN1 0.6 8.13 0.31 2.23e-15 Putamen volume; BRCA cis rs17253792 0.822 rs79873916 chr14:56172631 G/C cg01858014 chr14:56050164 KTN1 -0.74 -9.27 -0.34 2.85e-19 Putamen volume; BRCA cis rs703842 0.532 rs238516 chr12:58117355 T/C cg18357645 chr12:58087776 OS9 0.37 10.28 0.38 4.74e-23 Multiple sclerosis; BRCA cis rs11229555 0.874 rs11229519 chr11:58310587 C/T cg15696309 chr11:58395628 NA -0.53 -11.54 -0.42 4.18e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.55 0.39 4.3e-24 Motion sickness; BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg00149659 chr3:10157352 C3orf10 0.79 13.61 0.47 3.02e-37 Alzheimer's disease; BRCA cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg10932868 chr11:921992 NA 0.49 12.4 0.44 8.43e-32 Alzheimer's disease (late onset); BRCA trans rs208520 0.690 rs866452 chr6:66849936 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.31 -0.64 1.63e-76 Exhaled nitric oxide output; BRCA cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.27 0.31 7.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -8.55 -0.32 9.43e-17 Response to bleomycin (chromatid breaks); BRCA cis rs6598955 0.543 rs12122527 chr1:26549748 C/T cg12744634 chr1:26560303 CCDC21 0.3 8.18 0.31 1.49e-15 Obesity-related traits; BRCA cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg18963800 chr10:38644991 HSD17B7P2 -0.41 -7.84 -0.3 1.85e-14 Extrinsic epigenetic age acceleration; BRCA cis rs9807989 0.507 rs7584093 chr2:102997721 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.36 0.31 4.03e-16 Asthma; BRCA cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg16339924 chr4:17578868 LAP3 0.62 15.42 0.52 7.48e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17253792 0.822 rs28831725 chr14:56087569 C/T cg01858014 chr14:56050164 KTN1 -0.76 -10.26 -0.38 5.65e-23 Putamen volume; BRCA cis rs6977660 0.714 rs10486365 chr7:19801364 A/G cg05791153 chr7:19748676 TWISTNB 0.53 10.24 0.38 7.06e-23 Thyroid stimulating hormone; BRCA cis rs7617773 0.780 rs35297486 chr3:48378147 T/A cg11946769 chr3:48343235 NME6 0.67 13.37 0.47 3.99e-36 Coronary artery disease; BRCA cis rs9790314 0.602 rs4679926 chr3:160677240 A/T cg03342759 chr3:160939853 NMD3 0.46 8.87 0.33 7.57e-18 Morning vs. evening chronotype; BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg21782813 chr7:2030301 MAD1L1 0.4 10.6 0.39 2.66e-24 Bipolar disorder and schizophrenia; BRCA cis rs67460515 0.926 rs66508859 chr3:160946351 C/T cg03342759 chr3:160939853 NMD3 -0.8 -18.96 -0.6 5.94e-64 Parkinson's disease; BRCA cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg15839431 chr19:19639596 YJEFN3 -0.4 -8.66 -0.32 3.9e-17 Bipolar disorder; BRCA cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs3008870 1.000 rs12117131 chr1:67451922 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.45 -0.66 9.76e-83 Lymphocyte percentage of white cells; BRCA cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg04450456 chr4:17643702 FAM184B -0.34 -9.83 -0.36 2.41e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg08085267 chr17:45401833 C17orf57 -0.69 -15.23 -0.52 6.86e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs17270561 0.609 rs9379783 chr6:25725207 C/T cg16482183 chr6:26056742 HIST1H1C 0.41 8.27 0.31 7.69e-16 Iron status biomarkers; BRCA cis rs9807989 0.507 rs10208196 chr2:102996345 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.41 0.32 2.59e-16 Asthma; BRCA cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.54 0.32 9.51e-17 Bone mineral density; BRCA cis rs3772130 0.962 rs9883467 chr3:121517833 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.85 0.39 2.68e-25 Cognitive performance; BRCA trans rs7647973 0.626 rs9870858 chr3:49769071 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -8.49 -0.32 1.4e-16 Menarche (age at onset); BRCA cis rs11105298 0.685 rs117578503 chr12:89836672 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.84 -0.36 2.22e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9296092 0.538 rs35381461 chr6:33519751 T/C cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg18876405 chr7:65276391 NA -0.5 -10.98 -0.4 8.51e-26 Aortic root size; BRCA cis rs61160187 0.510 rs4577661 chr5:60040467 G/A cg02684056 chr5:59996105 DEPDC1B -0.33 -7.87 -0.3 1.56e-14 Educational attainment (years of education);Educational attainment (college completion); BRCA cis rs4845875 0.602 rs4846043 chr1:11839966 G/A cg24844545 chr1:11908347 NPPA 0.32 8.14 0.31 2.12e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs7254114 0.645 rs61045132 chr19:11303068 C/T cg02815516 chr19:11306319 KANK2 -0.33 -8.56 -0.32 8.42e-17 Immature fraction of reticulocytes; BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg00149659 chr3:10157352 C3orf10 0.79 13.66 0.48 1.77e-37 Alzheimer's disease; BRCA cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg22467129 chr15:76604101 ETFA -0.48 -10.35 -0.38 2.62e-23 Blood metabolite levels; BRCA cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg09658497 chr7:2847517 GNA12 -0.41 -7.84 -0.3 1.87e-14 Height; BRCA cis rs9560113 1.000 rs4773387 chr13:112180955 T/C cg10483660 chr13:112241077 NA 0.32 7.98 0.3 6.88e-15 Menarche (age at onset); BRCA cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg20603222 chr7:1096387 C7orf50;GPR146 0.38 8.03 0.3 4.56e-15 Longevity;Endometriosis; BRCA cis rs9467773 1.000 rs9467773 chr6:26498426 A/G cg11502198 chr6:26597334 ABT1 0.47 9.48 0.35 4.73e-20 Intelligence (multi-trait analysis); BRCA cis rs713587 1.000 rs2384054 chr2:25156773 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.63 0.36 1.33e-20 Body mass index in non-asthmatics; BRCA trans rs2980436 1 rs2980436 chr8:8092025 A/G cg16141378 chr3:129829833 LOC729375 0.43 10.31 0.38 3.81e-23 Schizophrenia; BRCA cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.11 0.49 1.43e-39 Motion sickness; BRCA cis rs13136331 0.500 rs1462371 chr4:88576655 T/C cg22416721 chr4:88570574 DMP1 -0.59 -14.33 -0.49 1.43e-40 Sitting height ratio; BRCA cis rs220324 0.688 rs56184115 chr21:43560554 G/T cg09727148 chr21:43560719 UMODL1 0.5 8.9 0.33 5.53e-18 Idiopathic osteonecrosis of the femoral head; BRCA cis rs509477 1.000 rs11660848 chr18:32574010 T/C cg00449728 chr18:32561817 MAPRE2 -0.35 -8.06 -0.3 3.72e-15 Cerebrospinal fluid AB1-42 levels; BRCA cis rs17270561 0.609 rs9358871 chr6:25726675 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs7178424 0.967 rs10468026 chr15:62343850 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.07 -0.3 3.61e-15 Height; BRCA cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg17420585 chr12:42539391 GXYLT1 -0.39 -8.14 -0.31 2.05e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.85 0.45 8.83e-34 Bipolar disorder; BRCA cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg00409905 chr10:38381863 ZNF37A -0.54 -11.51 -0.41 5.58e-28 Extrinsic epigenetic age acceleration; BRCA trans rs6951245 0.744 rs10265758 chr7:1172518 C/T cg13565492 chr6:43139072 SRF -0.84 -13.17 -0.46 3.33e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg10932868 chr11:921992 NA 0.49 12.51 0.44 2.84e-32 Alzheimer's disease (late onset); BRCA cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg08601574 chr20:25228251 PYGB -0.38 -9.01 -0.34 2.4e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.55e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1788820 0.917 rs1788785 chr18:21142340 T/C cg14672496 chr18:21087552 C18orf8 0.34 8.19 0.31 1.43e-15 Body mass index; BRCA cis rs7267979 1.000 rs1047171 chr20:25428786 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.17 -0.31 1.62e-15 Gut microbiome composition (summer); BRCA cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg24642439 chr20:33292090 TP53INP2 0.41 8.13 0.31 2.17e-15 Height; BRCA cis rs3760982 0.585 rs8109812 chr19:44298494 C/A cg12072164 chr19:44306565 LYPD5 0.36 8.7 0.33 2.75e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.77 0.45 1.99e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg10802521 chr3:52805072 NEK4 -0.33 -8.48 -0.32 1.61e-16 Bipolar disorder; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg23978390 chr7:1156363 C7orf50 0.38 9.21 0.34 4.45e-19 Longevity;Endometriosis; BRCA cis rs6582630 0.519 rs8189549 chr12:38245752 A/G cg26384229 chr12:38710491 ALG10B 0.75 17.0 0.56 9.05e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.73 14.55 0.5 1.26e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg13010199 chr12:38710504 ALG10B 0.53 10.82 0.39 3.59e-25 Heart rate; BRCA cis rs10883723 0.810 rs6584507 chr10:104254623 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2235642 0.691 rs2281235 chr16:1603535 T/C cg26528668 chr16:1614120 IFT140 0.39 9.0 0.34 2.47e-18 Coronary artery disease; BRCA cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg02196655 chr2:10830764 NOL10 -0.3 -8.07 -0.3 3.48e-15 Prostate cancer; BRCA cis rs9287719 0.967 rs10454738 chr2:10742049 G/A cg00105475 chr2:10696890 NA 0.44 10.37 0.38 2.16e-23 Prostate cancer; BRCA cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg12311346 chr5:56204834 C5orf35 -0.62 -13.03 -0.46 1.37e-34 Initial pursuit acceleration; BRCA cis rs12950390 0.512 rs11651000 chr17:45835278 G/A cg03474202 chr17:45855739 NA -0.43 -7.83 -0.3 2.06e-14 IgG glycosylation; BRCA trans rs9650657 0.644 rs4395858 chr8:10521021 C/T cg15556689 chr8:8085844 FLJ10661 0.37 9.6 0.36 1.82e-20 Neuroticism; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg05457628 chr5:178986728 RUFY1 0.58 14.36 0.49 1.02e-40 Lung cancer; BRCA cis rs965469 0.671 rs6139076 chr20:3305210 T/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.86 -0.33 7.91e-18 IFN-related cytopenia; BRCA cis rs2239547 0.563 rs4687699 chr3:53101224 C/T cg11645453 chr3:52864694 ITIH4 0.38 9.17 0.34 6.34e-19 Schizophrenia; BRCA trans rs2204008 0.580 rs11520047 chr12:38051778 T/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 7.99e-21 Bladder cancer; BRCA cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg10932868 chr11:921992 NA 0.48 12.2 0.43 6.15e-31 Alzheimer's disease (late onset); BRCA cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg26031613 chr14:104095156 KLC1 0.73 15.83 0.53 7.18e-48 Body mass index; BRCA cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg08859206 chr1:53392774 SCP2 -0.52 -11.18 -0.4 1.31e-26 Monocyte count; BRCA cis rs10779751 0.770 rs11585553 chr1:11233814 G/A cg08854313 chr1:11322531 MTOR -0.83 -14.89 -0.51 2.83e-43 Body mass index; BRCA cis rs6840360 0.571 rs28608620 chr4:152504791 C/T cg22705602 chr4:152727874 NA -0.32 -8.18 -0.31 1.57e-15 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg08888203 chr3:10149979 C3orf24 -0.65 -12.0 -0.43 4.53e-30 Alzheimer's disease; BRCA cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg24812749 chr6:127587940 RNF146 0.88 20.63 0.63 7.68e-73 Breast cancer; BRCA cis rs16910800 0.731 rs55908012 chr11:23191640 G/A cg20040320 chr11:23191996 NA -0.59 -10.23 -0.38 7.61e-23 Cancer; BRCA cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg03433033 chr1:76189801 ACADM 0.7 13.81 0.48 3.94e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2652834 1.000 rs2729784 chr15:63402735 T/C cg05507819 chr15:63340323 TPM1 0.45 8.32 0.31 5.39e-16 HDL cholesterol; BRCA cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs7737355 1.000 rs2551036 chr5:130648994 G/A cg06307176 chr5:131281290 NA 0.45 8.81 0.33 1.15e-17 Life satisfaction; BRCA cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg04455712 chr21:45112962 RRP1B 0.35 8.77 0.33 1.64e-17 Mean corpuscular volume; BRCA cis rs7737355 0.947 rs2215190 chr5:130921666 C/T cg06307176 chr5:131281290 NA 0.53 10.47 0.38 8.93e-24 Life satisfaction; BRCA cis rs4481887 1.000 rs7513161 chr1:248453422 A/T cg13385794 chr1:248469461 NA 0.29 7.87 0.3 1.48e-14 Common traits (Other); BRCA cis rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05901451 chr6:126070800 HEY2 -0.7 -20.37 -0.63 1.75e-71 Brugada syndrome; BRCA cis rs61931739 0.500 rs6488211 chr12:34375620 A/T cg06521331 chr12:34319734 NA 0.49 9.08 0.34 1.31e-18 Morning vs. evening chronotype; BRCA cis rs5758511 0.680 rs5758686 chr22:42655377 G/T cg00645731 chr22:42541494 CYP2D7P1 0.57 10.73 0.39 8.21e-25 Birth weight; BRCA cis rs2050392 0.624 rs303447 chr10:30728464 T/C cg18806716 chr10:30721971 MAP3K8 -0.6 -13.97 -0.48 6.51e-39 Inflammatory bowel disease; BRCA cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg27446573 chr6:127587934 RNF146 0.68 15.5 0.52 3.24e-46 Breast cancer; BRCA cis rs9807989 0.507 rs1420094 chr2:103015687 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.49 0.32 1.46e-16 Asthma; BRCA cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11644478 chr21:40555479 PSMG1 -0.67 -15.12 -0.51 2.35e-44 Cognitive function; BRCA cis rs7523273 0.606 rs2488255 chr1:207941741 C/T cg22525895 chr1:207977042 MIR29B2 0.47 11.89 0.43 1.42e-29 Schizophrenia; BRCA cis rs7666738 0.579 rs7672718 chr4:98645122 A/G cg05340658 chr4:99064831 C4orf37 0.56 11.03 0.4 5.06e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg24324837 chr19:49891574 CCDC155 0.53 9.67 0.36 9.98e-21 Multiple sclerosis; BRCA cis rs644148 0.836 rs2686777 chr19:45000386 T/C cg15540054 chr19:45004280 ZNF180 -0.57 -12.29 -0.44 2.67e-31 Personality dimensions; BRCA cis rs4845875 0.559 rs4846047 chr1:11843632 C/G cg24844545 chr1:11908347 NPPA 0.36 8.59 0.32 6.75e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg16414030 chr3:133502952 NA -0.4 -8.88 -0.33 6.61e-18 Iron status biomarkers; BRCA cis rs208520 0.609 rs208436 chr6:66897470 G/A cg07460842 chr6:66804631 NA -0.6 -11.09 -0.4 2.89e-26 Exhaled nitric oxide output; BRCA cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg04727924 chr7:799746 HEATR2 -0.53 -9.88 -0.36 1.63e-21 Cerebrospinal P-tau181p levels; BRCA cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.67e-36 Chronic sinus infection; BRCA cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg00106254 chr7:1943704 MAD1L1 -0.37 -9.78 -0.36 3.74e-21 Schizophrenia; BRCA cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg26408565 chr15:76604113 ETFA -0.47 -10.0 -0.37 5.73e-22 Blood metabolite levels; BRCA cis rs1401999 0.966 rs2292998 chr3:183663833 T/C cg01324343 chr3:183735012 ABCC5 0.83 20.96 0.64 1.25e-74 Anterior chamber depth; BRCA cis rs1371614 0.611 rs4665922 chr2:27133934 G/T cg12368169 chr2:27073192 DPYSL5 -0.29 -8.63 -0.32 4.84e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg18279126 chr7:2041391 MAD1L1 0.37 8.09 0.3 2.95e-15 Bipolar disorder and schizophrenia; BRCA cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg08048268 chr3:133502702 NA -0.41 -10.38 -0.38 1.94e-23 Iron status biomarkers; BRCA cis rs600806 0.821 rs3879451 chr1:109909269 C/T cg20591472 chr1:110008990 SYPL2 0.32 8.06 0.3 3.71e-15 Intelligence (multi-trait analysis); BRCA cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg26384229 chr12:38710491 ALG10B 0.7 15.82 0.53 8.5e-48 Morning vs. evening chronotype; BRCA cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.41 -8.54 -0.32 9.9e-17 Bipolar disorder; BRCA trans rs9858542 0.953 rs11926781 chr3:49603289 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.33 -0.35 1.68e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg11764359 chr7:65958608 NA 0.65 11.69 0.42 9.72e-29 Aortic root size; BRCA cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg07636037 chr3:49044803 WDR6 0.97 29.03 0.75 8.1e-119 Parkinson's disease; BRCA cis rs7607369 0.536 rs12623007 chr2:219665335 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -10.1 -0.37 2.41e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs2425143 1.000 rs12479473 chr20:34398628 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.53 -0.32 1.09e-16 Blood protein levels; BRCA cis rs3768617 0.510 rs1547712 chr1:183088013 T/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg17143192 chr8:8559678 CLDN23 0.57 11.1 0.4 2.61e-26 Obesity-related traits; BRCA cis rs4820539 1.000 rs756631 chr22:23463183 A/G cg14186256 chr22:23484241 RTDR1 0.76 22.93 0.67 2.17e-85 Bone mineral density; BRCA cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.71 -16.21 -0.54 9.25e-50 Axial length; BRCA trans rs3857536 0.704 rs4710570 chr6:66890244 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.54e-20 Blood trace element (Cu levels); BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg27170947 chr2:26402098 FAM59B -0.64 -11.42 -0.41 1.23e-27 Gut microbiome composition (summer); BRCA cis rs16958440 0.867 rs75287977 chr18:44686823 G/A cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg00071950 chr4:10020882 SLC2A9 0.51 11.69 0.42 9.18e-29 Bone mineral density; BRCA cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg10802521 chr3:52805072 NEK4 -0.33 -8.65 -0.32 4.15e-17 Bipolar disorder; BRCA cis rs2387326 0.717 rs12254442 chr10:129945793 C/T cg16087940 chr10:129947807 NA -0.45 -8.01 -0.3 5.38e-15 Select biomarker traits; BRCA cis rs9341808 0.727 rs10943697 chr6:80931506 A/C cg08355045 chr6:80787529 NA 0.39 9.98 0.37 6.98e-22 Sitting height ratio; BRCA cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg03264133 chr6:25882463 NA -0.58 -11.98 -0.43 5.76e-30 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs870825 0.616 rs1401359 chr4:185640216 T/C cg04058563 chr4:185651563 MLF1IP 0.76 16.91 0.56 2.85e-53 Blood protein levels; BRCA cis rs9467773 0.550 rs9379874 chr6:26440429 A/T cg09904177 chr6:26538194 HMGN4 -0.37 -9.8 -0.36 3.34e-21 Intelligence (multi-trait analysis); BRCA cis rs4953318 0.619 rs10198247 chr2:46362677 C/T cg12428440 chr2:46370979 PRKCE -0.48 -10.59 -0.39 3.02e-24 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg25838465 chr1:92012736 NA 0.67 19.12 0.6 8.94e-65 Breast cancer; BRCA cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg04455712 chr21:45112962 RRP1B 0.44 11.96 0.43 6.83e-30 Mean corpuscular volume; BRCA trans rs12310956 0.515 rs1852221 chr12:33945489 G/T cg26384229 chr12:38710491 ALG10B 0.5 10.79 0.39 4.61e-25 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg03146154 chr1:46216737 IPP -0.44 -9.9 -0.36 1.39e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg21770322 chr7:97807741 LMTK2 0.45 11.33 0.41 3.01e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs1580019 0.844 rs1376290 chr7:32486922 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.42 8.73 0.33 2.19e-17 Cognitive ability; BRCA cis rs3824867 0.920 rs7105907 chr11:47450318 A/T cg20307385 chr11:47447363 PSMC3 -0.49 -10.94 -0.4 1.16e-25 Mean corpuscular hemoglobin; BRCA cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.76 -0.42 5.03e-29 Bipolar disorder; BRCA cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs12474201 0.963 rs11676737 chr2:46929873 T/C cg06386533 chr2:46925753 SOCS5 0.87 18.81 0.6 3.9e-63 Height; BRCA cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg25019033 chr10:957182 NA -0.42 -8.07 -0.3 3.47e-15 Eosinophil percentage of granulocytes; BRCA cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 1.97e-48 Bladder cancer; BRCA cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg01877450 chr7:97915802 BRI3 -0.39 -8.61 -0.32 5.49e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg15485101 chr11:133734466 NA 0.4 9.73 0.36 5.69e-21 Childhood ear infection; BRCA cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg15595755 chr5:1867978 NA 0.34 8.29 0.31 6.9e-16 Cardiovascular disease risk factors; BRCA cis rs3862030 0.839 rs12570859 chr10:104257226 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.03 -0.43 3.42e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.87 -0.3 1.49e-14 Electroencephalogram traits; BRCA cis rs2070997 0.607 rs2855190 chr9:133708361 C/T cg11464064 chr9:133710261 ABL1 -0.52 -9.44 -0.35 6.63e-20 Response to amphetamines; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg05793240 chr7:2802953 GNA12 -0.32 -8.11 -0.31 2.54e-15 Height; BRCA cis rs8114671 0.967 rs6088753 chr20:33768252 C/T cg07148914 chr20:33460835 GGT7 0.38 7.99 0.3 6.35e-15 Height; BRCA cis rs6665290 0.935 rs17600627 chr1:227201449 A/G cg10327440 chr1:227177885 CDC42BPA -1.14 -45.45 -0.87 2.29e-202 Myeloid white cell count; BRCA cis rs13046373 0.507 rs2832969 chr21:32019627 A/G cg16812893 chr21:31813075 KRTAP15-1 0.38 9.41 0.35 8.66e-20 HDL cholesterol; BRCA cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg02880119 chr16:3481970 NA 0.48 8.75 0.33 1.91e-17 Body mass index (adult); BRCA cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.27 0.34 2.9e-19 Motion sickness; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg26608667 chr7:1196370 ZFAND2A 0.42 10.27 0.38 5.12e-23 Longevity;Endometriosis; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg22920501 chr2:26401640 FAM59B -0.96 -16.94 -0.56 2.01e-53 Gut microbiome composition (summer); BRCA cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg08213375 chr14:104286397 PPP1R13B 0.43 9.25 0.34 3.19e-19 Reticulocyte count; BRCA cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg06552810 chr11:31128660 NA -0.39 -8.81 -0.33 1.18e-17 Red blood cell count; BRCA cis rs7246657 0.525 rs10410594 chr19:37477758 C/T cg23950597 chr19:37808831 NA -0.6 -9.41 -0.35 8.83e-20 Coronary artery calcification; BRCA cis rs2288073 0.965 rs10199334 chr2:24392618 T/C cg06627628 chr2:24431161 ITSN2 -0.66 -12.11 -0.43 1.48e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs6594499 0.872 rs10060003 chr5:110449357 A/G cg04022379 chr5:110408740 TSLP 0.35 7.93 0.3 1.02e-14 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg19628046 chr18:33552617 C18orf21 0.53 10.37 0.38 2.07e-23 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9463078 0.801 rs9395079 chr6:45154433 C/T cg25276700 chr6:44698697 NA -0.36 -8.22 -0.31 1.17e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.21 -0.31 1.26e-15 Menarche (age at onset); BRCA cis rs4595586 0.545 rs1588970 chr12:39403122 C/A cg26384229 chr12:38710491 ALG10B 0.42 9.42 0.35 8.25e-20 Morning vs. evening chronotype; BRCA cis rs72792276 1.000 rs17164395 chr5:127395526 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.6 10.21 0.37 9.02e-23 Red cell distribution width; BRCA cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.84 12.5 0.44 3.17e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg00981070 chr1:2046702 PRKCZ 0.26 7.88 0.3 1.4e-14 Height; BRCA cis rs7551345 0.853 rs7517820 chr1:31760665 T/C cg19084893 chr1:31688959 NA -0.48 -7.85 -0.3 1.79e-14 Schizophrenia; BRCA cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg15997130 chr1:24165203 NA -0.45 -10.01 -0.37 5.43e-22 Immature fraction of reticulocytes; BRCA cis rs2762353 0.806 rs6909187 chr6:25785925 C/T cg03264133 chr6:25882463 NA 0.42 9.68 0.36 9.22e-21 Blood metabolite levels; BRCA cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg20476274 chr7:133979776 SLC35B4 0.7 21.47 0.65 2.12e-77 Mean platelet volume; BRCA cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg26384229 chr12:38710491 ALG10B 0.69 16.21 0.54 9.67e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs6430585 0.878 rs9677760 chr2:136538939 T/A cg07169764 chr2:136633963 MCM6 -0.89 -17.95 -0.58 1.19e-58 Corneal structure; BRCA cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg04455712 chr21:45112962 RRP1B -0.35 -8.95 -0.33 3.68e-18 Mean corpuscular volume; BRCA cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.29 -0.31 6.47e-16 Colorectal cancer; BRCA cis rs7618501 0.521 rs34654589 chr3:49911449 C/G cg14019146 chr3:50243930 SLC38A3 -0.46 -11.2 -0.41 1e-26 Intelligence (multi-trait analysis); BRCA cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg23033748 chr14:75592666 NEK9 -0.39 -9.36 -0.35 1.38e-19 Height; BRCA cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg06115741 chr20:33292138 TP53INP2 0.39 8.61 0.32 5.6e-17 Glomerular filtration rate (creatinine); BRCA cis rs6028335 0.674 rs66476511 chr20:37605303 T/A cg16355469 chr20:37678765 NA 0.48 8.75 0.33 1.88e-17 Alcohol and nicotine co-dependence; BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -12.34 -0.44 1.61e-31 Bipolar disorder and schizophrenia; BRCA cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg08213375 chr14:104286397 PPP1R13B 0.42 8.99 0.33 2.87e-18 Reticulocyte count; BRCA cis rs9640161 0.789 rs10952250 chr7:150025966 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.54 -13.59 -0.47 4.07e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs9880211 0.948 rs9872178 chr3:135986438 T/G cg21827317 chr3:136751795 NA -0.43 -7.83 -0.3 2.09e-14 Body mass index;Height; BRCA cis rs10876993 0.672 rs2640611 chr12:58037757 T/A cg18357645 chr12:58087776 OS9 0.43 11.88 0.43 1.52e-29 Celiac disease or Rheumatoid arthritis; BRCA cis rs7809950 1.000 rs4730245 chr7:107087294 C/T cg23024343 chr7:107201750 COG5 -0.42 -9.6 -0.36 1.76e-20 Coronary artery disease; BRCA trans rs6600671 0.934 rs67718113 chr1:121238910 C/T cg17023122 chr1:144479586 NA -0.35 -7.92 -0.3 1.09e-14 Hip geometry; BRCA cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.22e-36 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs7267979 0.932 rs433352 chr20:25467992 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.55 -0.32 9.18e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg05457628 chr5:178986728 RUFY1 0.41 8.57 0.32 7.48e-17 Lung cancer; BRCA cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.86 -0.3 1.61e-14 Electroencephalogram traits; BRCA cis rs2282802 0.685 rs7717576 chr5:139623591 G/A cg26211634 chr5:139558579 C5orf32 0.37 8.53 0.32 1.03e-16 Intelligence (multi-trait analysis); BRCA cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg14558114 chr2:88469736 THNSL2 0.63 9.18 0.34 6.08e-19 Plasma clusterin levels; BRCA cis rs700651 0.789 rs6434949 chr2:198855510 T/A cg00792783 chr2:198669748 PLCL1 0.44 9.68 0.36 9.05e-21 Intracranial aneurysm; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.46 0.41 9.15e-28 Age-related macular degeneration (geographic atrophy); BRCA trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg15704280 chr7:45808275 SEPT13 0.52 8.93 0.33 4.35e-18 Axial length; BRCA trans rs12310956 0.532 rs1906134 chr12:33957135 A/C cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs7737355 0.947 rs31253 chr5:130833011 A/C cg06307176 chr5:131281290 NA 0.53 10.56 0.39 4.02e-24 Life satisfaction; BRCA cis rs8180040 0.726 rs4682842 chr3:46982773 C/G cg27129171 chr3:47204927 SETD2 -0.71 -16.79 -0.55 1.08e-52 Colorectal cancer; BRCA cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg08975724 chr8:8085496 FLJ10661 -0.43 -9.58 -0.35 2.04e-20 Mood instability; BRCA cis rs12464559 0.522 rs6715027 chr2:152626657 T/C cg01189475 chr2:152685088 ARL5A 0.64 9.47 0.35 5.36e-20 Response to cognitive-behavioural therapy in anxiety disorder; BRCA trans rs10506458 0.915 rs998506 chr12:63400017 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -19.5 -0.61 8.19e-67 Hemostatic factors and hematological phenotypes; BRCA cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg13256891 chr4:100009986 ADH5 -0.53 -10.0 -0.37 5.45e-22 Alcohol dependence; BRCA cis rs4722404 0.502 rs1872879 chr7:3109430 A/C cg19214707 chr7:3157722 NA -0.37 -8.03 -0.3 4.58e-15 Atopic dermatitis; BRCA trans rs11098499 0.866 rs12513310 chr4:120288039 T/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.76 0.67 2.09e-84 Platelet count; BRCA cis rs3771570 1.000 rs62190367 chr2:242376276 G/A cg21155796 chr2:242212141 HDLBP 0.62 9.37 0.35 1.22e-19 Prostate cancer; BRCA cis rs9487051 0.768 rs445796 chr6:109520145 T/C cg01475377 chr6:109611718 NA -0.44 -11.28 -0.41 4.89e-27 Reticulocyte fraction of red cells; BRCA cis rs1595825 0.891 rs76637837 chr2:198529496 G/A cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.91e-15 Ulcerative colitis; BRCA cis rs9467773 1.000 rs6924838 chr6:26571756 C/T cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.93e-21 Intelligence (multi-trait analysis); BRCA cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg08923669 chr16:420230 MRPL28 -0.46 -8.99 -0.34 2.74e-18 Bone mineral density (spine);Bone mineral density; BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg15790184 chr11:494944 RNH1 0.64 9.95 0.37 8.42e-22 Body mass index; BRCA cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg19318889 chr4:1322082 MAEA 0.57 11.79 0.42 3.58e-29 Longevity; BRCA cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg04586622 chr2:25135609 ADCY3 -0.45 -11.31 -0.41 3.71e-27 Body mass index; BRCA cis rs6700896 0.931 rs12044840 chr1:66115213 C/G cg04111102 chr1:66153794 NA 0.34 8.42 0.32 2.57e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs17818399 0.620 rs7598578 chr2:46857085 T/C cg02822958 chr2:46747628 ATP6V1E2 0.43 8.36 0.31 4e-16 Height; BRCA cis rs17604090 0.793 rs10241305 chr7:29689929 T/C cg19413766 chr7:29689036 LOC646762 -0.49 -8.01 -0.3 5.4e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs11098499 0.826 rs12511640 chr4:120251248 T/C cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg26597838 chr10:835615 NA -0.52 -9.49 -0.35 4.61e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs7715811 0.913 rs6869474 chr5:13768691 C/T cg07548982 chr5:13769939 DNAH5 -0.38 -8.25 -0.31 9.13e-16 Subclinical atherosclerosis traits (other); BRCA cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.36 0.31 3.98e-16 Bladder cancer; BRCA cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2463822 1.000 rs12279819 chr11:62137245 G/A cg06239285 chr11:62104954 ASRGL1 -0.65 -9.63 -0.36 1.43e-20 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg22535103 chr8:58192502 C8orf71 -0.57 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs9329221 0.572 rs4841295 chr8:10105115 C/T cg06636001 chr8:8085503 FLJ10661 0.45 8.88 0.33 6.95e-18 Neuroticism; BRCA cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs17253792 0.822 rs28513551 chr14:56094993 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs6087990 0.899 rs998382 chr20:31384136 C/T cg13636640 chr20:31349939 DNMT3B -0.69 -21.87 -0.65 1.39e-79 Ulcerative colitis; BRCA cis rs7729447 0.776 rs58739438 chr5:32693994 G/C cg16267343 chr5:32710456 NPR3 0.44 9.06 0.34 1.6e-18 Blood pressure; BRCA cis rs72772090 0.539 rs10515250 chr5:96150193 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -11.94 -0.43 8.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg14993813 chr1:46806288 NSUN4 0.51 9.95 0.37 8.53e-22 Menopause (age at onset); BRCA cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.31 0.38 3.57e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs75804782 0.521 rs60779166 chr2:239433943 G/A cg01134436 chr17:81009848 B3GNTL1 0.7 8.78 0.33 1.5e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs7246760 0.867 rs1820114 chr19:9805692 G/A cg16876255 chr19:9731953 ZNF561 0.63 7.86 0.3 1.61e-14 Pursuit maintenance gain; BRCA cis rs4588572 0.644 rs891150 chr5:77761794 G/A cg11547950 chr5:77652471 NA -0.45 -8.6 -0.32 5.99e-17 Triglycerides; BRCA cis rs908922 0.676 rs7518654 chr1:152517845 C/G cg20991723 chr1:152506922 NA 0.38 8.75 0.33 1.89e-17 Hair morphology; BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg08888203 chr3:10149979 C3orf24 0.54 9.93 0.37 1.07e-21 Alzheimer's disease; BRCA cis rs4970988 0.787 rs1532770 chr1:150725335 G/T cg15448220 chr1:150897856 SETDB1 0.37 8.26 0.31 8.34e-16 Urate levels; BRCA cis rs2387326 0.672 rs10829344 chr10:129944569 A/C cg16087940 chr10:129947807 NA -0.45 -8.01 -0.3 5.47e-15 Select biomarker traits; BRCA cis rs9467773 0.620 rs2494694 chr6:26619328 A/T cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.11e-42 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg22920501 chr2:26401640 FAM59B -0.66 -11.52 -0.41 4.74e-28 Gut microbiome composition (summer); BRCA trans rs12188164 0.515 rs2672744 chr5:411047 A/G cg15371732 chr17:78194151 SLC26A11;SGSH -0.36 -9.21 -0.34 4.52e-19 Cystic fibrosis severity; BRCA cis rs11920090 0.858 rs61595505 chr3:170693472 C/T cg09710316 chr3:170744871 SLC2A2 0.51 8.09 0.3 2.95e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg03146154 chr1:46216737 IPP 0.46 10.02 0.37 4.61e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg10845886 chr2:3471009 TTC15 -0.54 -12.22 -0.44 5.48e-31 Neurofibrillary tangles; BRCA cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg19729930 chr2:74357872 NA 0.7 14.6 0.5 7.34e-42 Gestational age at birth (maternal effect); BRCA cis rs40363 0.645 rs250629 chr16:3525431 C/A cg22508957 chr16:3507546 NAT15 0.48 11.73 0.42 6.25e-29 Tuberculosis; BRCA trans rs11098499 0.754 rs2036857 chr4:120249240 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.4 0.38 1.72e-23 Corneal astigmatism; BRCA cis rs10789491 1.000 rs4660956 chr1:47158486 A/G cg15501359 chr1:47185051 KIAA0494 0.63 15.68 0.53 3.88e-47 Response to hepatitis C treatment; BRCA cis rs6546550 0.867 rs6738174 chr2:70150215 A/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.98e-28 Prevalent atrial fibrillation; BRCA cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.38 0.38 1.96e-23 Motion sickness; BRCA cis rs757110 0.803 rs7928810 chr11:17372443 G/T cg15432903 chr11:17409602 KCNJ11 0.71 15.76 0.53 1.64e-47 Type 2 diabetes; BRCA cis rs8062405 1.000 rs11861174 chr16:28871989 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11055008 0.620 rs2111941 chr12:12829404 A/T cg09462578 chr12:12878428 APOLD1 0.43 9.58 0.35 2.13e-20 Pulse pressure; BRCA cis rs2882667 0.658 rs10076442 chr5:138276779 T/C cg04439458 chr5:138467593 SIL1 -0.32 -8.31 -0.31 5.83e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 1.000 rs778685 chr7:65836176 G/T cg11764359 chr7:65958608 NA 0.8 19.53 0.61 6.05e-67 Aortic root size; BRCA cis rs13217239 0.646 rs9379956 chr6:27033735 T/C cg12292205 chr6:26970375 C6orf41 -0.56 -12.5 -0.44 3.17e-32 Schizophrenia; BRCA trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg22491629 chr6:157744540 C6orf35 -0.65 -12.0 -0.43 4.59e-30 Hemostatic factors and hematological phenotypes; BRCA cis rs6964587 0.773 rs59242586 chr7:91918145 A/G cg17063962 chr7:91808500 NA 0.51 11.17 0.4 1.4e-26 Breast cancer; BRCA cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg17971929 chr21:40555470 PSMG1 -0.49 -10.91 -0.4 1.5e-25 Menarche (age at onset); BRCA cis rs870825 0.698 rs66462315 chr4:185623917 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs9837602 1.000 rs34626154 chr3:99756312 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 10.22 0.37 8.31e-23 Breast cancer; BRCA cis rs12760731 0.565 rs12028023 chr1:178087408 G/A cg00404053 chr1:178313656 RASAL2 0.66 8.07 0.3 3.41e-15 Obesity-related traits; BRCA cis rs1865760 0.555 rs2051541 chr6:25945211 C/T cg12310025 chr6:25882481 NA 0.35 8.26 0.31 8.53e-16 Height; BRCA cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg22875332 chr1:76189707 ACADM -0.69 -15.07 -0.51 4.06e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7258465 0.965 rs8100767 chr19:18589088 T/C cg01065977 chr19:18549689 ISYNA1 -0.28 -8.35 -0.31 4.19e-16 Breast cancer; BRCA cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg12927641 chr6:109611667 NA -0.42 -10.93 -0.4 1.33e-25 Reticulocyte fraction of red cells; BRCA cis rs2652822 0.525 rs12148434 chr15:63510114 A/G cg02713581 chr15:63449717 RPS27L 0.41 8.3 0.31 6.28e-16 Metabolic traits; BRCA cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.43e-84 Chronic sinus infection; BRCA cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg02017074 chr12:117425053 FBXW8 0.56 10.74 0.39 7.6e-25 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs61931739 0.500 rs7979240 chr12:34509026 C/T cg06521331 chr12:34319734 NA -0.54 -9.84 -0.36 2.29e-21 Morning vs. evening chronotype; BRCA cis rs9354352 0.791 rs4710306 chr6:66700271 A/G cg07460842 chr6:66804631 NA -0.59 -12.59 -0.45 1.33e-32 Initial pursuit acceleration in psychotic disorders; BRCA cis rs867371 0.826 rs2047678 chr15:82498198 G/A cg00614314 chr15:82944287 LOC80154 0.38 7.88 0.3 1.47e-14 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs17604090 0.877 rs28516764 chr7:29685245 T/G cg19413766 chr7:29689036 LOC646762 -0.51 -7.99 -0.3 6.22e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg09184832 chr6:79620586 NA -0.44 -9.02 -0.34 2.23e-18 Intelligence (multi-trait analysis); BRCA cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg24130564 chr14:104152367 KLC1 -0.34 -7.94 -0.3 8.91e-15 Body mass index; BRCA cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg16506815 chr2:162101123 NA 0.51 11.12 0.4 2.15e-26 Intelligence (multi-trait analysis); BRCA cis rs939658 0.805 rs939661 chr15:79431063 A/G cg17916960 chr15:79447300 NA -0.45 -11.39 -0.41 1.75e-27 Refractive error; BRCA cis rs9790314 0.902 rs9863590 chr3:161116445 T/C cg03342759 chr3:160939853 NMD3 -0.62 -13.02 -0.46 1.53e-34 Morning vs. evening chronotype; BRCA cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg11833968 chr6:79620685 NA -0.4 -8.78 -0.33 1.55e-17 Intelligence (multi-trait analysis); BRCA cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg20090143 chr19:45452003 APOC2 0.27 7.89 0.3 1.31e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA trans rs7395662 0.864 rs10839201 chr11:48989417 A/G cg00717180 chr2:96193071 NA 0.3 8.23 0.31 1.03e-15 HDL cholesterol; BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.65 10.65 0.39 1.68e-24 Renal function-related traits (BUN); BRCA trans rs7939886 0.920 rs17150102 chr11:55904382 A/C cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs2953174 0.786 rs2953146 chr2:241515252 A/G cg07929629 chr2:241523174 NA -0.43 -8.22 -0.31 1.11e-15 Bipolar disorder; BRCA cis rs4363385 0.747 rs6704105 chr1:152964397 C/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.59 -0.35 1.87e-20 Inflammatory skin disease; BRCA cis rs870825 0.616 rs1401360 chr4:185643571 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs6878727 0.665 rs256853 chr5:123662595 C/T cg01806427 chr5:123737813 NA -0.36 -8.01 -0.3 5.53e-15 Breast cancer; BRCA cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg17971929 chr21:40555470 PSMG1 0.52 11.7 0.42 8.67e-29 Cognitive function; BRCA cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.58 -0.35 2.17e-20 Tonsillectomy; BRCA cis rs7000551 0.606 rs7844699 chr8:22248920 G/T cg23129673 chr8:22266227 SLC39A14 -0.39 -8.44 -0.32 2.13e-16 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs3820928 0.874 rs10177995 chr2:227781600 T/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.84 -0.33 8.95e-18 Pulmonary function; BRCA cis rs6546550 0.901 rs6741449 chr2:70156589 A/G cg02498382 chr2:70120550 SNRNP27 -0.52 -11.35 -0.41 2.54e-27 Prevalent atrial fibrillation; BRCA cis rs7582180 0.614 rs1530030 chr2:101009600 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.48 0.41 7.01e-28 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg13852791 chr20:30311386 BCL2L1 0.8 14.89 0.51 2.88e-43 Mean corpuscular hemoglobin; BRCA cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.42 0.32 2.44e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9837602 1.000 rs6790535 chr3:99807735 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 10.37 0.38 2.16e-23 Breast cancer; BRCA trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg25517755 chr10:38738941 LOC399744 -0.37 -7.87 -0.3 1.53e-14 Corneal astigmatism; BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.7 -12.14 -0.43 1.1e-30 Platelet count; BRCA cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg10169327 chr19:45448959 APOC2 0.31 7.83 0.3 2.05e-14 Blood protein levels; BRCA cis rs10782582 0.593 rs12142247 chr1:76235746 C/T cg10523679 chr1:76189770 ACADM -0.48 -9.01 -0.34 2.39e-18 Daytime sleep phenotypes; BRCA cis rs698813 0.572 rs13424464 chr2:44482263 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.44 7.84 0.3 1.85e-14 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg18230493 chr5:56204884 C5orf35 -0.73 -15.09 -0.51 3.09e-44 Initial pursuit acceleration; BRCA cis rs7914558 1.000 rs11191577 chr10:104902165 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.81 0.39 4e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg06060754 chr5:176797920 RGS14 0.57 10.96 0.4 1.01e-25 Hemoglobin concentration;Hematocrit; BRCA cis rs3818285 0.959 rs492943 chr10:111629030 A/T cg00817464 chr10:111662876 XPNPEP1 0.32 8.73 0.33 2.29e-17 Superior crus of antihelix expression; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg16145915 chr7:1198662 ZFAND2A -0.74 -22.42 -0.66 1.37e-82 Longevity;Endometriosis; BRCA cis rs501916 0.634 rs1561479 chr15:48070157 C/G cg16110827 chr15:48056943 SEMA6D -0.41 -8.83 -0.33 9.88e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs2243480 1.000 rs10807702 chr7:65767843 C/T cg18252515 chr7:66147081 NA -0.99 -14.71 -0.5 2.03e-42 Diabetic kidney disease; BRCA cis rs66887589 0.967 rs56173225 chr4:120509972 G/A cg09307838 chr4:120376055 NA -0.44 -9.18 -0.34 5.86e-19 Diastolic blood pressure; BRCA cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg02544614 chr20:61657117 NA 0.29 8.16 0.31 1.79e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs11098499 0.564 rs11098507 chr4:120288286 G/A cg09307838 chr4:120376055 NA 0.66 14.2 0.49 5.52e-40 Corneal astigmatism; BRCA cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg18225595 chr11:63971243 STIP1 0.53 9.58 0.35 2.09e-20 Mean platelet volume; BRCA cis rs12579753 1.000 rs12580330 chr12:82241280 T/G cg07988820 chr12:82153109 PPFIA2 -0.65 -10.48 -0.38 7.7e-24 Resting heart rate; BRCA cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg26408565 chr15:76604113 ETFA -0.47 -10.0 -0.37 5.88e-22 Blood metabolite levels; BRCA cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.65 -14.49 -0.5 2.33e-41 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.37 -0.44 1.18e-31 Lymphocyte counts; BRCA cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg03452623 chr4:187889614 NA 0.35 11.86 0.42 1.75e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg13010199 chr12:38710504 ALG10B -0.39 -8.86 -0.33 7.85e-18 Morning vs. evening chronotype; BRCA cis rs7639513 0.767 rs6784168 chr3:12702847 T/G cg23032965 chr3:12705835 RAF1 0.69 15.12 0.51 2.25e-44 Itch intensity from mosquito bite; BRCA cis rs17401966 0.931 rs3737155 chr1:10459779 G/A cg19773385 chr1:10388646 KIF1B -0.39 -8.37 -0.31 3.72e-16 Hepatocellular carcinoma; BRCA cis rs9467773 0.935 rs1884947 chr6:26553273 G/T cg09904177 chr6:26538194 HMGN4 0.5 14.26 0.49 2.89e-40 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26314531 chr2:26401878 FAM59B -0.78 -14.37 -0.49 8.64e-41 Gut microbiome composition (summer); BRCA cis rs12611088 0.571 rs2305375 chr19:44013260 C/T cg13740135 chr19:44006432 PHLDB3 -0.3 -7.94 -0.3 9.41e-15 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.05e-20 Menopause (age at onset); BRCA cis rs262150 1.000 rs262149 chr7:158778256 A/G cg19418458 chr7:158789849 NA 0.42 9.4 0.35 9.8e-20 Facial morphology (factor 20); BRCA cis rs425277 1.000 rs262665 chr1:2083173 A/G cg24578937 chr1:2090814 PRKCZ 0.58 17.95 0.58 1.28e-58 Height; BRCA trans rs11098499 0.863 rs3775849 chr4:120450908 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs1577917 1.000 rs12154056 chr6:86634094 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA cis rs1865760 0.519 rs2275904 chr6:25768085 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 10.43 0.38 1.29e-23 Height; BRCA cis rs9790314 0.875 rs55688744 chr3:160944222 G/A cg03342759 chr3:160939853 NMD3 -0.72 -17.66 -0.57 3.7e-57 Morning vs. evening chronotype; BRCA cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg17691542 chr6:26056736 HIST1H1C 0.55 11.62 0.42 1.82e-28 Height; BRCA cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.42 8.61 0.32 5.54e-17 Monocyte percentage of white cells; BRCA cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 8.73e-16 Height; BRCA cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg02297831 chr4:17616191 MED28 0.36 8.33 0.31 4.9e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.635 rs1486883 chr12:33908740 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.24 0.34 3.74e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg05340658 chr4:99064831 C4orf37 0.66 16.19 0.54 1.17e-49 Colonoscopy-negative controls vs population controls; BRCA trans rs62103177 0.810 rs62103187 chr18:77627633 G/C cg05926928 chr17:57297772 GDPD1 1.2 16.07 0.54 4.68e-49 Opioid sensitivity; BRCA cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg15557168 chr22:42548783 NA 0.33 8.68 0.32 3.41e-17 Cognitive function; BRCA cis rs10191773 0.589 rs72831634 chr2:112946796 A/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.61 7.81 0.3 2.34e-14 Yeast infection; BRCA cis rs6840360 0.615 rs6535822 chr4:152679722 A/G cg22705602 chr4:152727874 NA -0.38 -10.33 -0.38 3.1e-23 Intelligence (multi-trait analysis); BRCA cis rs67311347 1.000 rs1047855 chr3:40468896 A/G cg09455208 chr3:40491958 NA -0.5 -10.84 -0.39 3.12e-25 Renal cell carcinoma; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg23708337 chr7:1209742 NA 0.55 11.53 0.41 4.53e-28 Longevity;Endometriosis; BRCA cis rs611744 0.523 rs13253581 chr8:109343105 A/G cg21045802 chr8:109455806 TTC35 0.45 10.45 0.38 1.01e-23 Dupuytren's disease; BRCA cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg20476274 chr7:133979776 SLC35B4 0.7 21.34 0.65 1.05e-76 Mean platelet volume; BRCA cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg11301795 chr4:187892539 NA -0.31 -10.26 -0.38 6.01e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs7523273 0.606 rs2761433 chr1:207917361 G/A cg22525895 chr1:207977042 MIR29B2 0.47 12.11 0.43 1.61e-30 Schizophrenia; BRCA cis rs2835872 0.733 rs1787393 chr21:39035934 G/A cg06728970 chr21:39037746 KCNJ6 0.45 12.85 0.45 9.07e-34 Electroencephalographic traits in alcoholism; BRCA cis rs6456156 0.586 rs9457261 chr6:167467679 A/G cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.81e-21 Primary biliary cholangitis; BRCA cis rs365132 0.875 rs2940521 chr5:176339209 A/C cg16309518 chr5:176445507 NA -0.39 -9.67 -0.36 9.47e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg20701182 chr2:24300061 SF3B14 0.64 9.03 0.34 2.01e-18 Lymphocyte counts; BRCA cis rs778371 0.676 rs4973563 chr2:233716421 C/T cg08000102 chr2:233561755 GIGYF2 -0.79 -16.99 -0.56 1.1e-53 Schizophrenia; BRCA cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.05 0.46 1.08e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.37 -9.2 -0.34 5.08e-19 Blood protein levels;Circulating chemerin levels; BRCA cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg16339924 chr4:17578868 LAP3 0.58 13.38 0.47 3.5e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3761847 0.500 rs7037673 chr9:123740484 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.42 0.32 2.46e-16 Rheumatoid arthritis; BRCA cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.72e-15 Extrinsic epigenetic age acceleration; BRCA cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 10.19 0.37 1.12e-22 Aortic root size; BRCA cis rs6430585 0.528 rs3099429 chr2:136655582 T/A cg07169764 chr2:136633963 MCM6 1.02 19.42 0.61 2.33e-66 Corneal structure; BRCA cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg19784903 chr17:45786737 TBKBP1 -0.35 -8.21 -0.31 1.21e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3771570 0.901 rs73006381 chr2:242406654 G/C cg21155796 chr2:242212141 HDLBP 0.61 9.48 0.35 4.82e-20 Prostate cancer; BRCA cis rs10484885 0.793 rs9359862 chr6:90474508 A/G cg13799429 chr6:90582589 CASP8AP2 0.72 11.06 0.4 3.84e-26 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1451375 0.756 rs11761683 chr7:50542879 C/T cg18232548 chr7:50535776 DDC -0.48 -11.73 -0.42 6.28e-29 Malaria; BRCA cis rs35146811 0.735 rs11767968 chr7:99790971 G/A cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.52e-15 Coronary artery disease; BRCA cis rs2882667 0.964 rs12719517 chr5:138305502 C/T cg04439458 chr5:138467593 SIL1 -0.39 -9.87 -0.36 1.69e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2797160 1.000 rs9491471 chr6:125991715 C/T cg05901451 chr6:126070800 HEY2 -0.42 -10.14 -0.37 1.66e-22 Endometrial cancer; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg22907277 chr7:1156413 C7orf50 0.52 11.38 0.41 1.88e-27 Longevity;Endometriosis; BRCA cis rs754466 0.651 rs11002317 chr10:79617648 G/A cg17075019 chr10:79541650 NA -0.73 -17.63 -0.57 5.75e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9815354 0.812 rs111967505 chr3:41873157 C/T cg03022575 chr3:42003672 ULK4 0.69 9.47 0.35 5.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs3849570 0.925 rs6765917 chr3:81891116 C/T cg07356753 chr3:81810745 GBE1 -0.43 -10.23 -0.38 7.71e-23 Waist circumference;Body mass index; BRCA cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg02931644 chr1:25747376 RHCE 0.42 11.51 0.41 5.25e-28 Plateletcrit;Mean corpuscular volume; BRCA cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.02 0.49 3.85e-39 Motion sickness; BRCA cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg02403541 chr12:121454288 C12orf43 0.72 15.68 0.53 4e-47 N-glycan levels; BRCA cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.36 0.49 9.52e-41 Personality dimensions; BRCA cis rs12310956 0.515 rs11052934 chr12:33970381 T/C cg06521331 chr12:34319734 NA -0.53 -10.66 -0.39 1.51e-24 Morning vs. evening chronotype; BRCA cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg06115741 chr20:33292138 TP53INP2 0.4 8.99 0.34 2.78e-18 Coronary artery disease; BRCA cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA trans rs637571 0.522 rs550435 chr11:65732651 G/A cg17712092 chr4:129076599 LARP1B 0.53 12.98 0.46 2.26e-34 Eosinophil percentage of white cells; BRCA cis rs317689 0.513 rs317678 chr12:69692166 C/G cg14784868 chr12:69753453 YEATS4 0.47 10.99 0.4 7.58e-26 Response to diuretic therapy; BRCA cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg06784218 chr1:46089804 CCDC17 0.5 12.18 0.43 7.68e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg22535103 chr8:58192502 C8orf71 0.48 8.54 0.32 9.83e-17 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.8 0.48 4.21e-38 Coronary artery disease; BRCA cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.95 -0.37 8.64e-22 Tonsillectomy; BRCA cis rs495337 0.677 rs6012750 chr20:48430680 A/G cg17835207 chr20:48524531 SPATA2 0.49 11.07 0.4 3.65e-26 Psoriasis; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg26769984 chr7:1090371 C7orf50 0.5 9.58 0.35 2.16e-20 Bronchopulmonary dysplasia; BRCA cis rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05901451 chr6:126070800 HEY2 0.68 19.5 0.61 8.29e-67 Brugada syndrome; BRCA cis rs765787 0.530 rs16941017 chr15:45543281 T/C cg15395560 chr15:45543142 SLC28A2 0.29 7.96 0.3 8.05e-15 Uric acid levels; BRCA cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs9649465 1.000 rs2109724 chr7:123325391 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.96 0.33 3.4e-18 Tonsillectomy; BRCA trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg23505145 chr19:12996616 KLF1 0.56 12.73 0.45 2.95e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs7011049 1.000 rs72648407 chr8:53857144 C/T cg26025543 chr8:53854495 NA 0.55 9.5 0.35 4.24e-20 Systolic blood pressure; BRCA cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -18.59 -0.59 5.61e-62 Lobe attachment (rater-scored or self-reported); BRCA trans rs7939886 0.920 rs11227158 chr11:55843795 A/G cg15704280 chr7:45808275 SEPT13 0.6 7.84 0.3 1.92e-14 Myopia (pathological); BRCA cis rs17376456 0.877 rs28633397 chr5:93447048 A/G cg21475434 chr5:93447410 FAM172A 0.69 9.18 0.34 5.83e-19 Diabetic retinopathy; BRCA cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.91 22.88 0.67 4.42e-85 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA trans rs2235573 0.527 rs139885 chr22:38371039 C/T cg19894588 chr14:64061835 NA 0.37 8.98 0.33 2.93e-18 Glioblastoma;Glioma; BRCA cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.64 0.32 4.59e-17 Diabetic retinopathy; BRCA cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.11 0.37 2.23e-22 Aortic root size; BRCA trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.15 -0.37 1.56e-22 Intelligence (multi-trait analysis); BRCA cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg10820045 chr2:198174542 NA -0.38 -7.91 -0.3 1.1e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs193541 0.555 rs2438151 chr5:122199197 A/G cg19412675 chr5:122181750 SNX24 0.33 7.93 0.3 9.66e-15 Glucose homeostasis traits; BRCA trans rs634534 0.561 rs655744 chr11:65776585 G/T cg17712092 chr4:129076599 LARP1B -0.54 -12.91 -0.45 4.77e-34 Sum eosinophil basophil counts;Eosinophil counts; BRCA trans rs9354352 0.967 rs6455062 chr6:66694131 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 13.25 0.46 1.4e-35 Initial pursuit acceleration in psychotic disorders; BRCA cis rs4481887 0.927 rs7534188 chr1:248434303 C/T cg00666640 chr1:248458726 OR2T12 -0.29 -7.84 -0.3 1.84e-14 Common traits (Other); BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg20007245 chr22:24372913 LOC391322 -0.58 -12.9 -0.45 5.14e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg04025307 chr7:1156635 C7orf50 0.59 9.45 0.35 6.35e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.88 -0.4 2.07e-25 Schizophrenia; BRCA cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.83 -0.3 2.02e-14 Corneal astigmatism; BRCA cis rs910316 0.737 rs175499 chr14:75535927 G/A cg08847533 chr14:75593920 NEK9 -0.79 -18.55 -0.59 8.54e-62 Height; BRCA cis rs6430585 0.528 rs12474975 chr2:136702118 A/T cg07169764 chr2:136633963 MCM6 1.22 23.88 0.69 1.36e-90 Corneal structure; BRCA cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg03433033 chr1:76189801 ACADM 0.75 17.29 0.56 3.16e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9790314 0.637 rs778654 chr3:160716078 G/A cg03342759 chr3:160939853 NMD3 -0.47 -8.91 -0.33 5.28e-18 Morning vs. evening chronotype; BRCA cis rs911555 0.755 rs9671414 chr14:103967299 C/T cg24130564 chr14:104152367 KLC1 0.39 8.57 0.32 8.03e-17 Intelligence (multi-trait analysis); BRCA cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg14835575 chr10:16859367 RSU1 0.64 14.1 0.49 1.62e-39 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs6433895 1.000 rs7598960 chr2:182018382 T/G cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -8.13 -0.31 2.25e-15 Developmental language disorder (linguistic errors); BRCA cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.05 0.49 2.88e-39 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg26031613 chr14:104095156 KLC1 -0.43 -8.59 -0.32 6.54e-17 Schizophrenia; BRCA cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg18446336 chr7:2847575 GNA12 -0.35 -8.32 -0.31 5.18e-16 Height; BRCA cis rs1878931 0.531 rs9635548 chr16:3417156 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 12.07 0.43 2.27e-30 Body mass index (adult); BRCA cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg26408565 chr15:76604113 ETFA -0.37 -8.11 -0.31 2.67e-15 Blood metabolite levels; BRCA cis rs4728302 0.838 rs10225605 chr7:133591676 G/A cg07491979 chr7:133331646 EXOC4 0.36 7.82 0.3 2.17e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs2413784 chr15:45530516 A/C cg24006582 chr15:45444508 DUOX1 -0.53 -11.02 -0.4 5.69e-26 Uric acid levels; BRCA cis rs6782228 0.628 rs7641584 chr3:128392630 G/C cg16766828 chr3:128327626 NA -0.42 -9.33 -0.35 1.7e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg27170947 chr2:26402098 FAM59B 0.78 11.05 0.4 4.25e-26 Gut microbiome composition (summer); BRCA cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.03 -0.3 4.72e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs72781680 0.821 rs113014365 chr2:24159903 C/T cg08917208 chr2:24149416 ATAD2B 0.64 10.71 0.39 9.64e-25 Lymphocyte counts; BRCA cis rs3815700 0.920 rs10426856 chr19:33096406 A/G cg02997394 chr19:33096574 ANKRD27 0.69 11.34 0.41 2.72e-27 Eosinophilic esophagitis; BRCA cis rs611744 0.550 rs57045491 chr8:109279120 A/C cg21045802 chr8:109455806 TTC35 0.35 8.06 0.3 3.69e-15 Dupuytren's disease; BRCA cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.68 0.39 1.32e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs4594175 0.926 rs4901083 chr14:51604998 C/A cg23942311 chr14:51606299 NA 0.34 8.47 0.32 1.72e-16 Cancer; BRCA trans rs66887589 0.967 rs56173225 chr4:120509972 G/A cg25214090 chr10:38739885 LOC399744 -0.35 -8.09 -0.3 3.03e-15 Diastolic blood pressure; BRCA cis rs1538970 0.924 rs11211108 chr1:45891152 C/T cg05343316 chr1:45956843 TESK2 0.62 12.48 0.44 3.73e-32 Platelet count; BRCA cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg26384229 chr12:38710491 ALG10B -0.62 -15.05 -0.51 4.91e-44 Drug-induced liver injury (flucloxacillin); BRCA cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg16339924 chr4:17578868 LAP3 -0.56 -13.13 -0.46 5.09e-35 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs4566357 0.615 rs1800517 chr2:227915832 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -9.58 -0.35 2.16e-20 Coronary artery disease; BRCA cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.4 0.32 2.8e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 10.75 0.39 6.69e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10870270 1.000 rs6560695 chr10:133774986 C/A cg17892150 chr10:133769511 PPP2R2D -0.71 -15.3 -0.52 2.96e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs7945718 0.840 rs10741601 chr11:12735873 T/C cg25843174 chr11:12811716 TEAD1 0.23 8.55 0.32 9.3e-17 Educational attainment (years of education); BRCA cis rs7762018 0.607 rs7759404 chr6:170135728 A/G cg19338460 chr6:170058176 WDR27 -0.44 -7.84 -0.3 1.9e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg04450456 chr4:17643702 FAM184B 0.35 9.83 0.36 2.48e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6545883 0.894 rs1186703 chr2:61672965 A/C cg15711740 chr2:61764176 XPO1 -0.56 -14.29 -0.49 2.14e-40 Tuberculosis; BRCA cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg17971929 chr21:40555470 PSMG1 -0.5 -11.24 -0.41 7.24e-27 Menarche (age at onset); BRCA cis rs2985684 0.894 rs4581611 chr14:50043520 A/T cg04989706 chr14:50066350 PPIL5 -0.47 -9.21 -0.34 4.57e-19 Carotid intima media thickness; BRCA cis rs765787 0.530 rs4238377 chr15:45541981 A/G cg24006582 chr15:45444508 DUOX1 -0.56 -11.58 -0.42 2.68e-28 Uric acid levels; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg21248554 chr2:27665150 KRTCAP3 0.35 8.99 0.34 2.75e-18 Total body bone mineral density; BRCA cis rs12618769 0.597 rs72821956 chr2:99159966 G/T cg10123293 chr2:99228465 UNC50 0.43 8.47 0.32 1.65e-16 Bipolar disorder; BRCA cis rs10044254 0.563 rs12153463 chr5:15693370 G/A cg07238450 chr5:15720153 FBXL7 -0.38 -7.82 -0.3 2.13e-14 Asthma (corticosteroid response); BRCA cis rs6750047 0.649 rs4670231 chr2:38267836 T/G cg07380506 chr2:38303506 CYP1B1 0.43 9.51 0.35 3.94e-20 Cutaneous malignant melanoma;Melanoma; BRCA trans rs61931739 0.500 rs6488209 chr12:34319309 A/G cg26384229 chr12:38710491 ALG10B 0.46 10.5 0.38 6.62e-24 Morning vs. evening chronotype; BRCA cis rs16854884 0.657 rs35309714 chr3:143735011 T/A cg06585982 chr3:143692056 C3orf58 0.43 9.0 0.34 2.63e-18 Economic and political preferences (feminism/equality); BRCA cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg03934865 chr2:198174659 NA -0.44 -9.67 -0.36 1e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg10578991 chr7:12443926 VWDE -0.56 -7.92 -0.3 1.04e-14 Coronary artery disease; BRCA cis rs17685 0.523 rs10246583 chr7:75746667 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.65 -0.36 1.17e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs798554 0.704 rs798512 chr7:2782592 C/G cg09658497 chr7:2847517 GNA12 -0.41 -8.31 -0.31 5.82e-16 Height; BRCA cis rs858239 0.600 rs7787110 chr7:23138474 C/T cg23682824 chr7:23144976 KLHL7 0.45 12.1 0.43 1.8e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs1003719 0.680 rs2257091 chr21:38522618 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.37 -0.49 9.12e-41 Eye color traits; BRCA cis rs4746818 1.000 rs7893492 chr10:70960448 C/T cg11621586 chr10:70884670 VPS26A -0.74 -13.01 -0.46 1.74e-34 Left atrial antero-posterior diameter; BRCA cis rs7903847 0.642 rs10786341 chr10:99158607 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.34 -0.31 4.68e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg05347473 chr6:146136440 FBXO30 -0.45 -9.13 -0.34 8.82e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs897984 0.609 rs732172 chr16:31050033 C/T cg00531865 chr16:30841666 NA -0.36 -8.44 -0.32 2.18e-16 Dementia with Lewy bodies; BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg08470875 chr2:26401718 FAM59B -0.51 -8.59 -0.32 6.87e-17 Gut microbiome composition (summer); BRCA trans rs1005277 0.505 rs13503 chr10:38239843 C/A cg17830980 chr10:43048298 ZNF37B 0.43 10.12 0.37 1.94e-22 Extrinsic epigenetic age acceleration; BRCA cis rs17095355 0.818 rs57239324 chr10:111770871 T/C cg00817464 chr10:111662876 XPNPEP1 -0.45 -9.74 -0.36 5.35e-21 Biliary atresia; BRCA cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 22.3 0.66 6.23e-82 Platelet count; BRCA cis rs7560272 0.502 rs4513320 chr2:73920741 T/C cg20560298 chr2:73613845 ALMS1 0.36 9.47 0.35 5.37e-20 Schizophrenia; BRCA cis rs8062405 0.755 rs4788073 chr16:28594549 A/G cg16576597 chr16:28551801 NUPR1 0.32 8.83 0.33 1.01e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs589448 0.902 rs315138 chr12:69764850 A/T cg20891283 chr12:69753455 YEATS4 0.84 28.6 0.75 1.77e-116 Cerebrospinal fluid biomarker levels; BRCA cis rs7246657 0.943 rs2891699 chr19:37920237 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg18876405 chr7:65276391 NA -0.56 -13.42 -0.47 2.28e-36 Aortic root size; BRCA cis rs2304069 0.954 rs2340462 chr5:149415219 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.62 13.43 0.47 2.05e-36 HIV-1 control; BRCA cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg07828340 chr4:882639 GAK 0.8 10.28 0.38 4.7e-23 Parkinson's disease; BRCA cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg00071950 chr4:10020882 SLC2A9 0.64 15.73 0.53 2.16e-47 Bone mineral density; BRCA cis rs4566357 0.615 rs2272200 chr2:227912331 G/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.17 -0.31 1.69e-15 Coronary artery disease; BRCA trans rs4596713 0.538 rs7030146 chr9:71756390 T/G cg16512924 chr15:28394682 HERC2 0.42 10.07 0.37 3.07e-22 Headache; BRCA cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg08085267 chr17:45401833 C17orf57 -0.69 -15.26 -0.52 4.69e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10504073 0.584 rs4873307 chr8:49950417 C/T cg00325661 chr8:49890786 NA 0.49 14.39 0.49 7.32e-41 Blood metabolite ratios; BRCA cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg13385521 chr17:29058706 SUZ12P 0.77 12.14 0.43 1.15e-30 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg04317338 chr11:64019027 PLCB3 0.54 9.47 0.35 5.33e-20 Mean platelet volume; BRCA cis rs34779708 0.966 rs17591781 chr10:35498538 G/A cg03585969 chr10:35415529 CREM 0.49 10.25 0.38 6.11e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9314323 0.524 rs7816609 chr8:26202482 A/C cg13160058 chr8:26243215 BNIP3L -0.34 -8.76 -0.33 1.68e-17 Red cell distribution width; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.83 -0.33 1.03e-17 Total body bone mineral density; BRCA trans rs1997103 0.911 rs9642575 chr7:55399090 C/T cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs2204008 0.837 rs11180549 chr12:38236950 A/G cg06521331 chr12:34319734 NA -0.52 -9.41 -0.35 8.45e-20 Bladder cancer; BRCA cis rs12760731 0.720 rs35905053 chr1:178441618 A/T cg00404053 chr1:178313656 RASAL2 0.61 8.08 0.3 3.13e-15 Obesity-related traits; BRCA trans rs12310956 0.510 rs7965329 chr12:33868199 C/A cg26384229 chr12:38710491 ALG10B 0.39 9.15 0.34 7.57e-19 Morning vs. evening chronotype; BRCA trans rs61931739 0.569 rs1872746 chr12:33985843 T/C cg26384229 chr12:38710491 ALG10B 0.43 9.96 0.37 7.77e-22 Morning vs. evening chronotype; BRCA cis rs7011049 1.000 rs72643585 chr8:53847651 A/G cg26025543 chr8:53854495 NA 0.55 9.49 0.35 4.41e-20 Systolic blood pressure; BRCA trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.35 8.51 0.32 1.25e-16 Resting heart rate; BRCA cis rs17685 0.753 rs11982200 chr7:75714883 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.5 -0.32 1.31e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.54 0.44 2.18e-32 Bipolar disorder; BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg04944784 chr2:26401820 FAM59B 0.95 16.58 0.55 1.27e-51 Gut microbiome composition (summer); BRCA cis rs2041840 0.503 rs3770756 chr2:37573897 T/C cg25727520 chr2:37576821 QPCT -0.28 -7.81 -0.3 2.34e-14 Chronic lymphocytic leukemia; BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs7772486 0.686 rs1337839 chr6:146010239 A/G cg23711669 chr6:146136114 FBXO30 -0.68 -15.64 -0.53 6.62e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs10876993 0.928 rs10877001 chr12:58083077 T/C cg18357645 chr12:58087776 OS9 -0.47 -13.5 -0.47 9.71e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs2235642 0.893 rs2076440 chr16:1587322 G/A cg09065629 chr16:1709722 CRAMP1L 0.38 8.78 0.33 1.52e-17 Coronary artery disease; BRCA cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg02951883 chr7:2050386 MAD1L1 -0.47 -11.63 -0.42 1.66e-28 Schizophrenia; BRCA cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg08975724 chr8:8085496 FLJ10661 0.41 8.67 0.32 3.48e-17 Mood instability; BRCA cis rs2289583 0.642 rs11635266 chr15:75386649 T/C cg14664628 chr15:75095509 CSK 0.39 8.99 0.33 2.86e-18 Systemic lupus erythematosus; BRCA cis rs7727544 0.625 rs3091338 chr5:131402738 C/T cg14196790 chr5:131705035 SLC22A5 0.38 9.25 0.34 3.22e-19 Blood metabolite levels; BRCA cis rs9467773 1.000 rs9467774 chr6:26505036 C/A cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.12e-60 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg04267008 chr7:1944627 MAD1L1 -0.51 -10.88 -0.4 2.06e-25 Bipolar disorder and schizophrenia; BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg05863683 chr7:1912471 MAD1L1 0.38 8.49 0.32 1.41e-16 Bipolar disorder and schizophrenia; BRCA trans rs3733585 0.588 rs6449154 chr4:9956404 C/T cg26043149 chr18:55253948 FECH -0.37 -8.29 -0.31 6.69e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6061231 0.837 rs6061235 chr20:60978524 C/G cg06026331 chr20:60912101 LAMA5 0.44 8.16 0.31 1.75e-15 Colorectal cancer; BRCA cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg13798912 chr7:905769 UNC84A -0.5 -7.88 -0.3 1.42e-14 Cerebrospinal P-tau181p levels; BRCA cis rs6120849 0.802 rs6087681 chr20:33752896 G/C cg24642439 chr20:33292090 TP53INP2 0.48 8.56 0.32 8.7e-17 Protein C levels; BRCA trans rs10411161 0.702 rs16983200 chr19:52386723 G/A cg22319618 chr22:45562946 NUP50 -0.43 -8.04 -0.3 4.43e-15 Breast cancer; BRCA cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg02551604 chr5:131831745 NA 0.38 13.75 0.48 6.78e-38 Asthma (sex interaction); BRCA trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21659725 chr3:3221576 CRBN 0.7 20.95 0.64 1.37e-74 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg24549020 chr5:56110836 MAP3K1 -0.39 -8.07 -0.3 3.48e-15 Initial pursuit acceleration; BRCA cis rs12579753 1.000 rs7306395 chr12:82175867 A/G cg07988820 chr12:82153109 PPFIA2 -0.58 -9.61 -0.36 1.62e-20 Resting heart rate; BRCA trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg08975724 chr8:8085496 FLJ10661 -0.4 -7.92 -0.3 1.02e-14 Retinal vascular caliber; BRCA cis rs4671400 0.543 rs62152274 chr2:61499588 C/A cg15711740 chr2:61764176 XPO1 0.4 7.92 0.3 1.09e-14 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg00024416 chr22:24240387 NA 0.38 9.78 0.36 3.69e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -21.54 -0.65 8.57e-78 Gut microbiome composition (summer); BRCA cis rs9473147 0.516 rs9369695 chr6:47440565 C/A cg12968598 chr6:47444699 CD2AP 0.44 9.26 0.34 3.1400000000000002e-19 Platelet distribution width;Mean platelet volume; BRCA cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.8 -0.62 2.12e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs875971 0.543 rs801191 chr7:66032955 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.8 -0.33 1.24e-17 Aortic root size; BRCA cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg13319975 chr6:146136371 FBXO30 -0.34 -8.05 -0.3 3.93e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs11190604 1.000 rs7905961 chr10:102297391 G/C cg07080220 chr10:102295463 HIF1AN 0.57 13.41 0.47 2.65e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs250677 0.524 rs40521 chr5:148439639 C/T cg12140854 chr5:148520817 ABLIM3 0.37 8.51 0.32 1.2e-16 Breast cancer; BRCA cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg01416388 chr22:39784598 NA -0.39 -8.06 -0.3 3.67e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs4268898 0.722 rs7563958 chr2:24422381 C/A cg06627628 chr2:24431161 ITSN2 0.47 9.97 0.37 7.1e-22 Asthma; BRCA cis rs17376456 0.569 rs6879620 chr5:93119893 G/A cg25358565 chr5:93447407 FAM172A -0.67 -11.67 -0.42 1.17e-28 Diabetic retinopathy; BRCA cis rs4285028 0.948 rs34478505 chr3:121694071 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.88 -0.4 2.15e-25 Multiple sclerosis; BRCA cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -11.5 -0.41 6.24e-28 Glomerular filtration rate (creatinine); BRCA cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 9.03 0.34 2e-18 Cognitive ability; BRCA cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg02175503 chr12:58329896 NA 0.44 8.5 0.32 1.31e-16 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg03264133 chr6:25882463 NA -0.54 -12.42 -0.44 7.33e-32 Blood metabolite levels; BRCA cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg23649088 chr2:200775458 C2orf69 -0.62 -10.05 -0.37 3.77e-22 Schizophrenia; BRCA cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg12591125 chr7:1885375 MAD1L1 0.51 8.93 0.33 4.6e-18 Bipolar disorder; BRCA cis rs61931739 0.500 rs11053210 chr12:34461771 A/G cg06521331 chr12:34319734 NA 0.56 9.73 0.36 6.07e-21 Morning vs. evening chronotype; BRCA cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.4 -0.35 9.47e-20 Menopause (age at onset); BRCA cis rs9790314 0.645 rs6778254 chr3:160892792 T/C cg03342759 chr3:160939853 NMD3 -0.57 -12.13 -0.43 1.22e-30 Morning vs. evening chronotype; BRCA cis rs2404602 0.684 rs8029283 chr15:76837140 A/G cg23625390 chr15:77176239 SCAPER -0.56 -14.37 -0.49 9.19e-41 Blood metabolite levels; BRCA cis rs9467711 0.591 rs10484433 chr6:26030492 G/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.56 8.85 0.33 8.42e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs250677 0.524 rs417413 chr5:148452726 T/C cg12140854 chr5:148520817 ABLIM3 -0.37 -8.3 -0.31 6.18e-16 Breast cancer; BRCA cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.76 0.57 1.24e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs2070488 0.965 rs4679060 chr3:38536261 T/C cg24069376 chr3:38537580 EXOG -0.43 -12.28 -0.44 2.92e-31 Electrocardiographic conduction measures; BRCA cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg11608241 chr8:8085544 FLJ10661 -0.29 -8.75 -0.33 1.87e-17 Mood instability; BRCA cis rs2797160 1.000 rs1935774 chr6:125996661 A/G cg05901451 chr6:126070800 HEY2 0.4 9.7 0.36 7.3e-21 Endometrial cancer; BRCA cis rs9287719 0.967 rs7600820 chr2:10740044 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.73 16.36 0.54 1.75e-50 Hip circumference adjusted for BMI; BRCA cis rs2795502 1.000 rs2795497 chr10:43339475 C/A cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 16.38 0.54 1.35e-50 Colorectal cancer; BRCA cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg24549020 chr5:56110836 MAP3K1 0.64 13.06 0.46 9.94e-35 Initial pursuit acceleration; BRCA cis rs9527 0.590 rs2148198 chr10:104915310 A/G cg04362960 chr10:104952993 NT5C2 -0.44 -9.99 -0.37 5.95e-22 Arsenic metabolism; BRCA cis rs4679121 0.642 rs55708952 chr3:126188912 A/G cg01106040 chr3:126194903 ZXDC -0.67 -7.96 -0.3 7.83e-15 Pursuit maintenance gain; BRCA cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs4808199 1.000 rs4808199 chr19:19545099 C/T cg03709012 chr19:19516395 GATAD2A 1.05 20.42 0.63 9.41e-72 Nonalcoholic fatty liver disease; BRCA cis rs853679 0.517 rs7755442 chr6:28039015 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.15e-15 Depression; BRCA cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg26384229 chr12:38710491 ALG10B 0.85 22.93 0.67 2.44e-85 Heart rate; BRCA cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg26061582 chr7:22766209 IL6 0.35 8.31 0.31 5.56e-16 Lung cancer; BRCA cis rs7633770 0.710 rs4683259 chr3:46698538 A/G cg11219411 chr3:46661640 NA -0.52 -12.16 -0.43 9.9e-31 Coronary artery disease; BRCA cis rs67460515 0.892 rs35100811 chr3:161084046 A/C cg04691961 chr3:161091175 C3orf57 -0.41 -9.18 -0.34 5.99e-19 Parkinson's disease; BRCA cis rs6882046 0.513 rs618298 chr5:88038390 A/G cg22951263 chr5:87985283 NA -0.34 -9.38 -0.35 1.09e-19 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg06115741 chr20:33292138 TP53INP2 -0.39 -8.67 -0.32 3.46e-17 Glomerular filtration rate (creatinine); BRCA cis rs4713118 0.513 rs149962 chr6:28015918 G/A cg10876282 chr6:28092338 ZSCAN16 0.4 7.84 0.3 1.9e-14 Parkinson's disease; BRCA trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg11707556 chr5:10655725 ANKRD33B -0.45 -9.99 -0.37 6.1e-22 Coronary artery disease; BRCA trans rs12439619 1.000 rs35152457 chr15:82546548 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.42 -10.44 -0.38 1.13e-23 Intelligence (multi-trait analysis); BRCA cis rs752010 0.571 rs10890135 chr1:42054084 G/A cg06885757 chr1:42089581 HIVEP3 0.22 8.01 0.3 5.4e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.22 0.49 4.5e-40 Colorectal cancer; BRCA cis rs7631605 0.905 rs7634972 chr3:37205716 C/T cg15934958 chr3:37212084 LRRFIP2 0.42 9.87 0.36 1.69e-21 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7809950 0.598 rs2283038 chr7:106835410 C/T cg23024343 chr7:107201750 COG5 -0.46 -9.1 -0.34 1.16e-18 Coronary artery disease; BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.11 -0.4 2.32e-26 Gut microbiome composition (summer); BRCA cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg15145296 chr3:125709740 NA -0.55 -8.92 -0.33 5.02e-18 Blood pressure (smoking interaction); BRCA cis rs2066819 0.892 rs17118431 chr12:56667100 A/G cg26714650 chr12:56694279 CS -1.16 -15.27 -0.52 3.93e-45 Psoriasis vulgaris; BRCA cis rs10189230 0.967 rs13026659 chr2:222353014 C/T cg14652038 chr2:222343519 EPHA4 0.47 13.14 0.46 4.22e-35 Urate levels in lean individuals; BRCA cis rs8072100 0.782 rs28507314 chr17:45551402 C/T cg08085267 chr17:45401833 C17orf57 -0.62 -13.37 -0.47 4.19e-36 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs950776 0.593 rs555018 chr15:78879242 G/A cg06917634 chr15:78832804 PSMA4 -0.6 -13.13 -0.46 5.15e-35 Sudden cardiac arrest; BRCA cis rs66679842 1 rs66679842 chr6:88171407 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -8.38 -0.31 3.34e-16 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4595586 0.545 rs925827 chr12:39364307 C/T cg26384229 chr12:38710491 ALG10B 0.43 9.52 0.35 3.41e-20 Morning vs. evening chronotype; BRCA cis rs11792861 0.962 rs72607162 chr9:111793719 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.86 0.3 1.66e-14 Menarche (age at onset); BRCA cis rs9325144 0.625 rs11534879 chr12:38968165 A/G cg26384229 chr12:38710491 ALG10B -0.48 -11.49 -0.41 6.5e-28 Morning vs. evening chronotype; BRCA cis rs12760731 0.565 rs12030488 chr1:178094751 A/C cg00404053 chr1:178313656 RASAL2 -0.62 -7.93 -0.3 1.01e-14 Obesity-related traits; BRCA cis rs17270561 0.609 rs760698 chr6:25685889 A/G cg16482183 chr6:26056742 HIST1H1C 0.42 8.14 0.31 2.15e-15 Iron status biomarkers; BRCA cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.2 -0.41 1.01e-26 Schizophrenia; BRCA cis rs2712184 0.756 rs2541393 chr2:217651230 G/C cg05032264 chr2:217675019 NA -0.38 -9.15 -0.34 7.75e-19 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg08888203 chr3:10149979 C3orf24 0.65 13.74 0.48 7.58e-38 Alzheimer's disease; BRCA cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg06484146 chr7:12443880 VWDE -0.65 -10.12 -0.37 1.98e-22 Coronary artery disease; BRCA cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg22153463 chr1:85462885 MCOLN2 -0.62 -12.23 -0.44 4.88e-31 Serum sulfate level; BRCA trans rs11098499 0.604 rs17051352 chr4:120581427 G/A cg25214090 chr10:38739885 LOC399744 0.52 10.74 0.39 7.27e-25 Corneal astigmatism; BRCA cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg01475377 chr6:109611718 NA -0.61 -16.82 -0.55 8.28e-53 Reticulocyte fraction of red cells; BRCA cis rs1371614 0.635 rs12612520 chr2:27137307 C/T cg12368169 chr2:27073192 DPYSL5 -0.3 -8.96 -0.33 3.45e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg22337977 chr21:31811175 KRTAP15-1 0.35 8.31 0.31 5.84e-16 HDL cholesterol; BRCA cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg01579765 chr21:45077557 HSF2BP -0.45 -11.95 -0.43 7.37e-30 Mean corpuscular volume; BRCA cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.32 -0.38 3.23e-23 Psoriasis; BRCA cis rs4663866 0.901 rs76312449 chr2:239190906 A/G cg16914508 chr2:239161102 PER2 0.69 9.38 0.35 1.09e-19 Irritable bowel syndrome; BRCA cis rs9359856 0.510 rs17294495 chr6:90445753 T/G cg13799429 chr6:90582589 CASP8AP2 -0.71 -10.75 -0.39 7.08e-25 Bipolar disorder; BRCA cis rs9858542 1.000 rs9858542 chr3:49701983 A/G cg03060546 chr3:49711283 APEH 0.56 10.99 0.4 7.41e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg05623727 chr3:50126028 RBM5 0.43 10.08 0.37 2.94e-22 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg03517284 chr6:25882590 NA 0.46 10.42 0.38 1.35e-23 Blood metabolite levels; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg09060608 chr5:178986726 RUFY1 0.54 12.71 0.45 3.73e-33 Lung cancer; BRCA cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg10495392 chr1:46806563 NSUN4 0.45 8.49 0.32 1.42e-16 Menopause (age at onset); BRCA cis rs11690935 0.569 rs62183770 chr2:172838117 C/G cg13550731 chr2:172543902 DYNC1I2 0.5 12.07 0.43 2.43e-30 Schizophrenia; BRCA cis rs858239 0.601 rs12539331 chr7:23151330 A/G cg23682824 chr7:23144976 KLHL7 0.4 10.35 0.38 2.62e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.32 -9.57 -0.35 2.22e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs4290604 0.748 rs6431514 chr2:238051064 T/C cg23555395 chr2:238036564 NA -0.5 -8.16 -0.31 1.72e-15 Asthma; BRCA cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg23625390 chr15:77176239 SCAPER 0.38 9.13 0.34 8.91e-19 Blood metabolite levels; BRCA cis rs7760949 0.889 rs9475806 chr6:13934527 A/G cg27413430 chr6:13925136 RNF182 0.47 9.41 0.35 8.55e-20 Mean corpuscular hemoglobin concentration; BRCA cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.89 0.51 2.78e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs782590 0.837 rs782584 chr2:55921116 C/G cg18811423 chr2:55921094 PNPT1 -0.78 -28.11 -0.74 8.19e-114 Metabolic syndrome; BRCA cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg25427524 chr10:38739819 LOC399744 -0.74 -18.02 -0.58 5.19e-59 Extrinsic epigenetic age acceleration; BRCA cis rs28830936 1.000 rs28830936 chr15:41906408 G/A cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.34 -0.35 1.61e-19 Diastolic blood pressure; BRCA cis rs61931739 0.534 rs4931783 chr12:34115322 G/A cg06521331 chr12:34319734 NA -0.61 -11.21 -0.41 9.27e-27 Morning vs. evening chronotype; BRCA cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg12923728 chr3:195709715 SDHAP1 -0.61 -12.48 -0.44 3.79e-32 Pancreatic cancer; BRCA cis rs6570726 0.935 rs452552 chr6:145820781 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs12541635 0.966 rs34177605 chr8:107065105 G/A cg10147462 chr8:107024639 NA 0.38 9.88 0.36 1.6e-21 Age of smoking initiation; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg21724239 chr8:58056113 NA 0.56 9.08 0.34 1.3e-18 Developmental language disorder (linguistic errors); BRCA cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg11366901 chr6:160182831 ACAT2 0.82 15.87 0.53 4.73e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs11098499 0.954 rs11940028 chr4:120411907 T/C cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.91e-45 Corneal astigmatism; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg22920501 chr2:26401640 FAM59B 0.95 16.32 0.54 2.51e-50 Gut microbiome composition (summer); BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.24 -0.31 9.49e-16 Total body bone mineral density; BRCA cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg01877450 chr7:97915802 BRI3 -0.39 -8.9 -0.33 5.76e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs8067545 0.611 rs12603372 chr17:20181566 C/T cg13482628 chr17:19912719 NA 0.48 12.55 0.44 1.8e-32 Schizophrenia; BRCA cis rs1499972 0.941 rs62263120 chr3:117630253 A/G cg07612923 chr3:117604196 NA 0.6 8.15 0.31 1.97e-15 Schizophrenia; BRCA cis rs7633770 0.769 rs2385858 chr3:46660436 T/C cg11219411 chr3:46661640 NA 0.72 20.93 0.64 1.73e-74 Coronary artery disease; BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.19 0.34 5.28e-19 Tonsillectomy; BRCA cis rs11718455 1.000 rs11917515 chr3:44020237 A/G cg08738300 chr3:44038990 NA 0.44 8.56 0.32 8.6e-17 Coronary artery disease; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg25036284 chr2:26402008 FAM59B 0.63 10.38 0.38 2.01e-23 Gut microbiome composition (summer); BRCA cis rs6738485 0.601 rs13011900 chr2:106845059 G/C cg16099169 chr2:106886729 NA -0.41 -8.76 -0.33 1.69e-17 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs13190036 1.000 rs4976682 chr5:176726002 A/G cg06733329 chr5:176740039 MXD3 -0.45 -8.75 -0.33 1.85e-17 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg18105134 chr13:113819100 PROZ -0.62 -14.1 -0.49 1.64e-39 Platelet distribution width; BRCA cis rs2346177 0.580 rs1530628 chr2:46670941 A/G cg02822958 chr2:46747628 ATP6V1E2 0.54 11.88 0.43 1.45e-29 HDL cholesterol; BRCA cis rs4588572 0.643 rs6874309 chr5:77774498 A/T cg11547950 chr5:77652471 NA 0.47 8.51 0.32 1.26e-16 Triglycerides; BRCA cis rs897984 0.542 rs7294 chr16:31102321 A/G cg00531865 chr16:30841666 NA 0.38 9.05 0.34 1.74e-18 Dementia with Lewy bodies; BRCA cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg24110177 chr3:50126178 RBM5 0.38 10.35 0.38 2.65e-23 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.12 0.31 2.49e-15 Menopause (age at onset); BRCA cis rs7246657 0.551 rs11084873 chr19:37583910 A/G cg18154014 chr19:37997991 ZNF793 0.53 8.68 0.32 3.16e-17 Coronary artery calcification; BRCA cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg07636037 chr3:49044803 WDR6 0.73 15.88 0.53 4.04e-48 Menarche (age at onset); BRCA cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg04450456 chr4:17643702 FAM184B 0.37 10.98 0.4 8.29e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg06784218 chr1:46089804 CCDC17 -0.45 -10.8 -0.39 4.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2070433 0.556 rs8129460 chr21:47822544 C/T cg05998816 chr21:47859926 PCNT 0.36 8.54 0.32 9.59e-17 Lymphocyte counts; BRCA cis rs11229555 0.645 rs4506677 chr11:58213852 T/C cg15696309 chr11:58395628 NA -0.45 -9.64 -0.36 1.27e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs35995292 0.534 rs13228087 chr7:38909204 A/C cg19327137 chr7:38886074 VPS41 0.4 13.3 0.47 8.14e-36 Subjective well-being (multi-trait analysis); BRCA cis rs7809950 0.817 rs3779495 chr7:107250260 G/A cg23024343 chr7:107201750 COG5 0.51 10.48 0.38 7.77e-24 Coronary artery disease; BRCA cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.86e-54 Bladder cancer; BRCA cis rs16976116 0.901 rs28864456 chr15:55503092 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.52 0.38 5.59e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg06618935 chr21:46677482 NA -0.36 -7.98 -0.3 6.64e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2882667 0.893 rs10069961 chr5:138294568 A/G cg04439458 chr5:138467593 SIL1 -0.32 -8.54 -0.32 1.01e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.29e-16 Schizophrenia; BRCA cis rs9296092 0.517 rs56206922 chr6:33522567 C/T cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg07828340 chr4:882639 GAK 1.07 14.28 0.49 2.32e-40 Intelligence (multi-trait analysis); BRCA cis rs2625529 0.526 rs11637611 chr15:72551712 C/T cg16672083 chr15:72433130 SENP8 0.62 14.71 0.5 2.21e-42 Red blood cell count; BRCA cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg23711669 chr6:146136114 FBXO30 0.75 17.25 0.56 4.93e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs9291683 0.679 rs2241483 chr4:10099831 A/G cg26043149 chr18:55253948 FECH -0.4 -8.8 -0.33 1.28e-17 Bone mineral density; BRCA cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.0 -0.34 2.61e-18 Developmental language disorder (linguistic errors); BRCA cis rs2974760 0.606 rs6600143 chr16:201389 A/C cg01839639 chr16:202542 HBZ 0.35 7.89 0.3 1.32e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.49 0.41 6.35e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs495337 0.760 rs624115 chr20:48523628 C/T cg17835207 chr20:48524531 SPATA2 -0.66 -15.85 -0.53 5.68e-48 Psoriasis; BRCA trans rs629535 0.725 rs639127 chr8:70073251 A/G cg21567404 chr3:27674614 NA 1.01 21.13 0.64 1.52e-75 Dupuytren's disease; BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.27 0.34 2.71e-19 Tonsillectomy; BRCA cis rs3812565 0.530 rs10781538 chr9:139320929 C/G cg14169450 chr9:139327907 INPP5E -0.46 -11.32 -0.41 3.25e-27 Granulocyte percentage of myeloid white cells; BRCA cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg06784218 chr1:46089804 CCDC17 0.49 11.45 0.41 1e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2559856 1.000 rs2559856 chr12:102089561 A/G cg12924262 chr12:102091054 CHPT1 0.39 8.67 0.32 3.54e-17 Blood protein levels; BRCA cis rs1256061 0.654 rs1256031 chr14:64746179 C/T cg23250157 chr14:64679961 SYNE2 0.3 8.09 0.3 3e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs9486719 1.000 rs11756315 chr6:97008678 A/G cg06623918 chr6:96969491 KIAA0776 0.75 13.79 0.48 4.53e-38 Migraine;Coronary artery disease; BRCA cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg12386194 chr3:101231763 SENP7 0.4 8.62 0.32 5.29e-17 Colorectal cancer; BRCA trans rs6479891 1.000 rs2893922 chr10:65247019 G/T cg14819942 chr15:35414228 NA -0.34 -8.51 -0.32 1.24e-16 Arthritis (juvenile idiopathic); BRCA cis rs9287719 0.967 rs7600728 chr2:10739999 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA trans rs12517041 1.000 rs12519798 chr5:23290006 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.99 0.4 7.26e-26 Bipolar disorder; BRCA cis rs679087 0.932 rs10843507 chr12:29931056 C/A cg14258853 chr12:29935411 TMTC1 0.36 8.26 0.31 8.17e-16 Schizophrenia; BRCA cis rs11764590 0.694 rs6461115 chr7:2103668 A/G cg23422044 chr7:1970798 MAD1L1 -0.41 -8.63 -0.32 4.79e-17 Neuroticism; BRCA cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.19 -0.4 1.19e-26 Extrinsic epigenetic age acceleration; BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.53 0.35 3.26e-20 Tonsillectomy; BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.48 -8.32 -0.31 5.32e-16 Renal function-related traits (BUN); BRCA cis rs11229555 0.645 rs10896775 chr11:58175989 A/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836633 0.929 rs58120977 chr21:40037346 C/T cg05519781 chr21:40033154 ERG 0.44 9.34 0.35 1.61e-19 Coronary artery disease; BRCA cis rs698813 0.572 rs4953076 chr2:44480950 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.27 0.31 7.55e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs7917772 0.560 rs35095897 chr10:104377759 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.72 -0.48 9.78e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.01e-15 Alzheimer's disease (late onset); BRCA cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs10992471 0.603 rs7045572 chr9:95137964 T/C cg14631576 chr9:95140430 CENPP -0.4 -9.68 -0.36 8.86e-21 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs17376456 0.569 rs1349711 chr5:93179032 C/T cg25358565 chr5:93447407 FAM172A -0.64 -11.14 -0.4 1.88e-26 Diabetic retinopathy; BRCA cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.54 -0.44 2.15e-32 Developmental language disorder (linguistic errors); BRCA cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg18404041 chr3:52824283 ITIH1 -0.28 -8.26 -0.31 8.39e-16 Electroencephalogram traits; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg22907277 chr7:1156413 C7orf50 0.41 8.73 0.33 2.28e-17 Longevity;Endometriosis; BRCA cis rs9715521 0.589 rs11726451 chr4:59852381 A/C cg11281224 chr4:60001000 NA -0.38 -8.82 -0.33 1.12e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg12311346 chr5:56204834 C5orf35 -0.81 -16.08 -0.54 4.04e-49 Initial pursuit acceleration; BRCA trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg17470723 chr8:74884337 TCEB1 0.39 8.52 0.32 1.17e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs858239 0.570 rs10242166 chr7:23162799 A/G cg23682824 chr7:23144976 KLHL7 0.45 12.1 0.43 1.81e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg08601574 chr20:25228251 PYGB 0.34 8.36 0.31 3.9e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.21 -0.34 4.57e-19 Alzheimer's disease (late onset); BRCA cis rs62380364 0.602 rs610217 chr5:88065263 G/A cg22951263 chr5:87985283 NA -0.38 -10.39 -0.38 1.81e-23 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.605 rs6718767 chr2:227800776 A/G cg05526886 chr2:227700861 RHBDD1 -0.42 -8.71 -0.33 2.57e-17 Pulmonary function; BRCA cis rs11920090 0.860 rs35297160 chr3:170738981 C/G cg09710316 chr3:170744871 SLC2A2 0.48 8.82 0.33 1.08e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -12.78 -0.45 1.88e-33 Bipolar disorder; BRCA trans rs11976180 1.000 rs13243677 chr7:143746572 T/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.43 -8.0 -0.3 5.89e-15 Obesity-related traits; BRCA cis rs1050631 0.564 rs1785905 chr18:33713287 T/A cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.99 -0.3 6.25e-15 Esophageal squamous cell cancer (length of survival); BRCA cis rs7818345 0.935 rs4333618 chr8:19283442 G/C cg11303988 chr8:19266685 CSGALNACT1 0.31 8.22 0.31 1.12e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg11764359 chr7:65958608 NA 0.77 17.66 0.57 3.66e-57 Aortic root size; BRCA trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg11887960 chr12:57824829 NA 0.5 8.27 0.31 7.83e-16 Lung disease severity in cystic fibrosis; BRCA cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg25554036 chr4:6271136 WFS1 0.37 9.07 0.34 1.45e-18 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg03146154 chr1:46216737 IPP -0.44 -9.8 -0.36 3.14e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.93 0.56 2.16e-53 Bladder cancer; BRCA cis rs13082711 0.911 rs2371065 chr3:27494589 A/C cg02860705 chr3:27208620 NA 0.59 11.05 0.4 4.22e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs11608355 0.515 rs61941592 chr12:109930497 G/A cg05360138 chr12:110035743 NA 0.73 13.43 0.47 2.08e-36 Neuroticism; BRCA cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg13880726 chr7:1868755 MAD1L1 0.47 9.2 0.34 4.96e-19 Bipolar disorder and schizophrenia; BRCA cis rs763121 0.524 rs760645 chr22:39032270 C/T cg06544989 chr22:39130855 UNC84B 0.35 8.15 0.31 1.9e-15 Menopause (age at onset); BRCA cis rs2282526 0.615 rs463738 chr21:44921166 G/A cg04455712 chr21:45112962 RRP1B -0.37 -8.46 -0.32 1.82e-16 Mean corpuscular hemoglobin; BRCA cis rs12545109 0.800 rs1992122 chr8:57409467 A/G cg09654669 chr8:57350985 NA -0.38 -8.24 -0.31 9.83e-16 Obesity-related traits; BRCA cis rs10746514 0.841 rs9725652 chr1:232245997 T/A cg09506761 chr1:232265262 NA 0.48 10.38 0.38 1.94e-23 Response to statin therapy; BRCA cis rs6545883 0.931 rs12713437 chr2:61722904 C/T cg15711740 chr2:61764176 XPO1 -0.55 -13.99 -0.48 5.71e-39 Tuberculosis; BRCA cis rs1953600 0.837 rs2819946 chr10:81951635 G/A cg04850286 chr10:81895943 PLAC9 0.31 8.94 0.33 4.08e-18 Sarcoidosis; BRCA cis rs3772130 0.885 rs9816844 chr3:121496324 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.68 0.39 1.31e-24 Cognitive performance; BRCA cis rs1635 0.655 rs60698636 chr6:28316045 A/G cg15743358 chr6:28303923 ZNF323 -0.74 -8.61 -0.32 5.76e-17 Schizophrenia; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg23708337 chr7:1209742 NA 0.63 8.84 0.33 8.9e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 19.13 0.6 7.84e-65 Platelet count; BRCA cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg00071950 chr4:10020882 SLC2A9 -0.46 -10.9 -0.4 1.78e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3862030 0.720 rs12569526 chr10:104237007 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -13.24 -0.46 1.56e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.83 0.51 5.53e-43 Colorectal cancer; BRCA cis rs12200560 0.505 rs211171 chr6:97070579 T/G cg06623918 chr6:96969491 KIAA0776 0.52 12.25 0.44 3.94e-31 Coronary heart disease; BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg04267008 chr7:1944627 MAD1L1 -0.54 -10.88 -0.4 2.05e-25 Bipolar disorder and schizophrenia; BRCA cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg18876405 chr7:65276391 NA -0.55 -12.62 -0.45 9.73e-33 Aortic root size; BRCA cis rs2404602 0.647 rs116090606 chr15:77075209 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.89 -0.48 1.61e-38 Blood metabolite levels; BRCA cis rs12200560 0.505 rs1988040 chr6:97076271 G/A cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg27129171 chr3:47204927 SETD2 0.74 18.78 0.6 5.59e-63 Colorectal cancer; BRCA trans rs6952808 0.692 rs11765549 chr7:2027311 G/T cg04565464 chr8:145669602 NFKBIL2 0.37 8.75 0.33 1.96e-17 Bipolar disorder and schizophrenia; BRCA trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg17470723 chr8:74884337 TCEB1 0.44 9.13 0.34 8.75e-19 Prostate cancer (SNP x SNP interaction); BRCA cis rs7917772 0.503 rs7068535 chr10:104349127 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 18.28 0.59 2.39e-60 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg07308232 chr7:1071921 C7orf50 -0.39 -8.27 -0.31 7.49e-16 Longevity;Endometriosis; BRCA cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg02187348 chr16:89574699 SPG7 -0.45 -10.78 -0.39 5.3e-25 Multiple myeloma (IgH translocation); BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg11843238 chr5:131593191 PDLIM4 0.34 8.8 0.33 1.3e-17 Breast cancer; BRCA cis rs4363385 0.818 rs1415969 chr1:153006448 G/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.84 -0.3 1.86e-14 Inflammatory skin disease; BRCA cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg19539972 chr4:7069911 GRPEL1 0.7 16.36 0.54 1.58e-50 Monocyte percentage of white cells; BRCA trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg22800045 chr5:56110881 MAP3K1 -0.64 -12.32 -0.44 1.88e-31 Initial pursuit acceleration; BRCA cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg11657440 chr19:46296263 DMWD -0.55 -13.09 -0.46 7.26e-35 Coronary artery disease; BRCA cis rs17376456 0.569 rs68122392 chr5:93077807 A/T cg25358565 chr5:93447407 FAM172A 0.7 11.94 0.43 8.08e-30 Diabetic retinopathy; BRCA cis rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05901451 chr6:126070800 HEY2 0.4 9.72 0.36 6.35e-21 Endometrial cancer; BRCA cis rs7267979 1.000 rs4813563 chr20:25365340 T/C cg08601574 chr20:25228251 PYGB -0.35 -8.64 -0.32 4.54e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs10751667 0.666 rs6597958 chr11:978087 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg06784218 chr1:46089804 CCDC17 -0.47 -10.55 -0.39 4.12e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs877282 1.000 rs10904552 chr10:774326 A/G cg17470449 chr10:769945 NA 0.5 9.49 0.35 4.33e-20 Uric acid levels; BRCA cis rs250677 0.524 rs40521 chr5:148439639 C/T cg18129178 chr5:148520854 ABLIM3 0.48 10.39 0.38 1.85e-23 Breast cancer; BRCA cis rs12971120 0.891 rs2278159 chr18:72178161 T/C cg26446133 chr18:72167187 CNDP2 -0.74 -12.91 -0.45 4.65e-34 Refractive error; BRCA cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg26874164 chr19:58962979 ZNF324B 0.43 9.0 0.34 2.46e-18 Uric acid clearance; BRCA cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg06064525 chr11:970664 AP2A2 0.3 8.76 0.33 1.71e-17 Alzheimer's disease (late onset); BRCA cis rs7572733 0.534 rs6760891 chr2:198768166 T/G cg00792783 chr2:198669748 PLCL1 0.49 10.43 0.38 1.31e-23 Dermatomyositis; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.84 15.26 0.52 4.65e-45 Platelet count; BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg27170947 chr2:26402098 FAM59B -0.81 -13.07 -0.46 9.07e-35 Gut microbiome composition (summer); BRCA cis rs36051895 0.658 rs12346093 chr9:5021140 T/A cg02405213 chr9:5042618 JAK2 -0.51 -8.94 -0.33 3.99e-18 Pediatric autoimmune diseases; BRCA cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.25 -8.27 -0.31 7.58e-16 Schizophrenia; BRCA trans rs1493916 0.721 rs4799723 chr18:31367050 T/G cg27147174 chr7:100797783 AP1S1 -0.54 -10.42 -0.38 1.42e-23 Life satisfaction; BRCA cis rs2762353 0.935 rs1359232 chr6:25809716 C/A cg12310025 chr6:25882481 NA 0.5 11.94 0.43 8.64e-30 Blood metabolite levels; BRCA cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg02228329 chr11:64053129 BAD;GPR137 0.54 12.0 0.43 4.46e-30 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg11764359 chr7:65958608 NA 0.65 11.57 0.42 3.14e-28 Aortic root size; BRCA cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg11764359 chr7:65958608 NA 0.66 12.08 0.43 2.07e-30 Aortic root size; BRCA cis rs6963495 0.745 rs2392749 chr7:105182605 A/G cg19920283 chr7:105172520 RINT1 0.67 13.47 0.47 1.46e-36 Bipolar disorder (body mass index interaction); BRCA cis rs9815354 0.767 rs73081335 chr3:41895177 A/G cg03022575 chr3:42003672 ULK4 0.68 9.46 0.35 5.93e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg00071950 chr4:10020882 SLC2A9 0.63 15.86 0.53 5.11e-48 Bone mineral density; BRCA cis rs3820928 0.845 rs1917126 chr2:227840923 G/T cg11843606 chr2:227700838 RHBDD1 -0.37 -8.31 -0.31 5.79e-16 Pulmonary function; BRCA cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg13010199 chr12:38710504 ALG10B 0.55 11.67 0.42 1.2e-28 Heart rate; BRCA cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.2 0.41 1e-26 Bipolar disorder; BRCA cis rs10751667 0.961 rs7943115 chr11:973885 T/C ch.11.42038R chr11:967971 AP2A2 0.58 19.17 0.6 5.03e-65 Alzheimer's disease (late onset); BRCA cis rs72829446 0.530 rs4796421 chr17:7379650 C/T cg02795151 chr17:7402630 POLR2A 0.65 11.49 0.41 6.64e-28 Androgen levels; BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg06468780 chr21:31798236 KRTAP13-3 0.34 8.56 0.32 8.15e-17 HDL cholesterol; BRCA cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg24692254 chr21:30365293 RNF160 0.6 15.87 0.53 4.43e-48 Dental caries; BRCA cis rs9287719 0.934 rs10201077 chr2:10752426 A/C cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA trans rs9858542 0.953 rs34363169 chr3:49537712 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.66 -0.36 1.04e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08704250 chr15:31115839 NA 0.34 8.85 0.33 8.75e-18 Huntington's disease progression; BRCA trans rs7786808 0.608 rs6978352 chr7:158209802 T/C cg02030672 chr11:45687055 CHST1 -0.41 -9.15 -0.34 7.53e-19 Obesity-related traits; BRCA cis rs2652834 1.000 rs2652816 chr15:63403368 C/T cg05507819 chr15:63340323 TPM1 0.45 8.26 0.31 8.19e-16 HDL cholesterol; BRCA cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs2235642 1.000 rs2235642 chr16:1584866 T/C cg09065629 chr16:1709722 CRAMP1L 0.37 8.69 0.32 3.13e-17 Coronary artery disease; BRCA cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.36 -0.31 3.92e-16 Developmental language disorder (linguistic errors); BRCA cis rs16866061 0.962 rs16866045 chr2:225413020 G/A cg12698349 chr2:225449008 CUL3 0.78 21.23 0.64 4.46e-76 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 25.18 0.71 9.98e-98 Platelet count; BRCA cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.17e-23 Motion sickness; BRCA cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs5017598 1.000 rs5017598 chr6:169211494 A/G cg05672967 chr6:169256475 NA 0.35 8.15 0.31 1.97e-15 Pediatric bone mineral density (femoral neck);Pediatric bone mineral density (hip); BRCA cis rs4481887 0.861 rs4575112 chr1:248473534 A/G cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA trans rs7615952 0.932 rs13065725 chr3:125632289 C/A cg07211511 chr3:129823064 LOC729375 -1.05 -18.66 -0.59 2.48e-62 Blood pressure (smoking interaction); BRCA trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg03929089 chr4:120376271 NA 0.54 9.15 0.34 7.6e-19 Axial length; BRCA cis rs4908768 0.501 rs6677736 chr1:8552804 A/T cg20416874 chr1:8611966 RERE -0.29 -8.32 -0.31 5.4e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg17971929 chr21:40555470 PSMG1 0.79 18.92 0.6 1.04e-63 Cognitive function; BRCA cis rs9462027 0.628 rs6899938 chr6:34749113 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.2e-15 Systemic lupus erythematosus; BRCA cis rs17401966 0.838 rs12132134 chr1:10378428 A/G cg03954927 chr1:10346856 KIF1B 0.43 13.53 0.47 7.6e-37 Hepatocellular carcinoma; BRCA cis rs7246967 0.673 rs35061555 chr19:22963766 T/C cg23217946 chr19:22817039 ZNF492 0.5 9.11 0.34 1.04e-18 Bronchopulmonary dysplasia; BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg08280861 chr8:58055591 NA 0.61 9.32 0.35 1.81e-19 Developmental language disorder (linguistic errors); BRCA cis rs28374715 0.662 rs13329579 chr15:41467435 C/T cg18705301 chr15:41695430 NDUFAF1 -0.85 -17.71 -0.57 2.15e-57 Ulcerative colitis; BRCA cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.55 -9.24 -0.34 3.66e-19 Schizophrenia; BRCA cis rs2239547 0.607 rs9836178 chr3:52925403 T/C cg11645453 chr3:52864694 ITIH4 -0.46 -11.38 -0.41 1.86e-27 Schizophrenia; BRCA cis rs9796 0.558 rs8043253 chr15:41503730 C/T cg18705301 chr15:41695430 NDUFAF1 -0.37 -8.28 -0.31 7.26e-16 Menopause (age at onset); BRCA cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9682041 0.696 rs16855034 chr3:170097842 C/G cg11886554 chr3:170076028 SKIL 0.51 10.11 0.37 2.1e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.61 11.96 0.43 6.74e-30 Multiple sclerosis; BRCA cis rs9393777 1.000 rs9393777 chr6:26942027 T/C cg12826209 chr6:26865740 GUSBL1 0.67 9.74 0.36 5.19e-21 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg17366294 chr4:99064904 C4orf37 0.43 9.89 0.36 1.45e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs698813 0.789 rs2592195 chr2:44607707 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.56 10.59 0.39 3.05e-24 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA trans rs3733585 0.699 rs28613263 chr4:9964880 C/T cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg12292205 chr6:26970375 C6orf41 -0.64 -10.65 -0.39 1.66e-24 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs62318504 chr4:98935558 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7809950 0.817 rs4727678 chr7:107083635 C/G cg23024343 chr7:107201750 COG5 -0.5 -10.49 -0.38 7.39e-24 Coronary artery disease; BRCA cis rs61931739 0.534 rs7313137 chr12:34010231 T/G cg06521331 chr12:34319734 NA -0.62 -11.25 -0.41 6.25e-27 Morning vs. evening chronotype; BRCA cis rs4319547 0.615 rs2341439 chr12:122848096 C/G cg23029597 chr12:123009494 RSRC2 -0.57 -11.19 -0.4 1.14e-26 Body mass index; BRCA cis rs9393777 0.513 rs13219181 chr6:27136225 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.34 -8.74 -0.33 2.05e-17 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.61 -0.36 1.58e-20 Mean corpuscular volume; BRCA cis rs858239 0.600 rs2014768 chr7:23122440 C/A cg23682824 chr7:23144976 KLHL7 0.45 12.23 0.44 4.63e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg02574844 chr11:5959923 NA -0.42 -8.04 -0.3 4.25e-15 DNA methylation (variation); BRCA cis rs1832871 0.672 rs56115227 chr6:158773884 G/A cg07165851 chr6:158734300 TULP4 0.64 12.76 0.45 2.27e-33 Height; BRCA cis rs4808199 0.842 rs11085259 chr19:19445856 C/T cg03709012 chr19:19516395 GATAD2A 0.99 18.37 0.59 8.18e-61 Nonalcoholic fatty liver disease; BRCA trans rs9325144 0.650 rs6582631 chr12:38744135 T/C cg23762105 chr12:34175262 ALG10 -0.41 -10.06 -0.37 3.39e-22 Morning vs. evening chronotype; BRCA cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.42 11.75 0.42 5.35e-29 Monocyte percentage of white cells; BRCA cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs17376456 1.000 rs17376207 chr5:93545524 C/T cg21475434 chr5:93447410 FAM172A -0.63 -8.46 -0.32 1.82e-16 Diabetic retinopathy; BRCA trans rs1997103 1.000 rs2331065 chr7:55408392 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1577917 0.740 rs7775864 chr6:86247759 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 8.99 0.34 2.79e-18 Response to antipsychotic treatment; BRCA cis rs9323205 0.861 rs55763867 chr14:51608567 G/A cg23942311 chr14:51606299 NA -0.44 -9.54 -0.35 2.89e-20 Cancer; BRCA cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg24450063 chr1:156163899 SLC25A44 0.94 18.49 0.59 1.82e-61 Testicular germ cell tumor; BRCA cis rs17401966 0.867 rs6696056 chr1:10305992 C/A cg03954927 chr1:10346856 KIF1B 0.43 13.72 0.48 1.01e-37 Hepatocellular carcinoma; BRCA cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.67 0.39 1.46e-24 Chronic sinus infection; BRCA cis rs7914558 1.000 rs3740387 chr10:104849468 G/A cg04362960 chr10:104952993 NT5C2 0.43 10.31 0.38 3.72e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg12564285 chr5:131593104 PDLIM4 0.31 8.2 0.31 1.34e-15 Blood metabolite levels; BRCA cis rs4595586 0.545 rs11610886 chr12:39390613 C/G cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs12541635 0.966 rs12680670 chr8:107006811 T/G cg10147462 chr8:107024639 NA 0.37 9.98 0.37 6.74e-22 Age of smoking initiation; BRCA cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg09060608 chr5:178986726 RUFY1 0.45 9.44 0.35 7.1e-20 Lung cancer; BRCA cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Depression; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg04013093 chr6:42928303 GNMT -0.28 -8.88 -0.33 6.98e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg14004847 chr7:1930337 MAD1L1 -0.45 -9.58 -0.35 2.06e-20 Bipolar disorder and schizophrenia; BRCA cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg16339924 chr4:17578868 LAP3 0.57 13.78 0.48 5.21e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -15.45 -0.52 5.49e-46 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.32 0.41 3.49e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg24558204 chr6:135376177 HBS1L -0.53 -14.48 -0.5 2.6e-41 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg18016565 chr1:150552671 MCL1 0.34 7.95 0.3 8.65e-15 Tonsillectomy; BRCA cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg14844989 chr11:31128820 NA 0.44 9.62 0.36 1.47e-20 Red blood cell count; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg24101359 chr6:42928495 GNMT -0.42 -9.97 -0.37 7.52e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.94 0.4 1.16e-25 Cognitive ability; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs1468333 0.930 rs2269954 chr5:137501003 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.44 8.66 0.32 3.92e-17 Resting heart rate; BRCA cis rs754466 0.651 rs11818687 chr10:79637709 C/T cg17075019 chr10:79541650 NA -0.75 -18.04 -0.58 4.02e-59 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg18765753 chr7:1198926 ZFAND2A -0.46 -10.36 -0.38 2.4e-23 Longevity;Endometriosis; BRCA cis rs7847628 0.587 rs12684934 chr9:123593159 C/T cg03808351 chr9:123631620 PHF19 0.61 12.82 0.45 1.27e-33 Birth weight; BRCA cis rs7829975 0.539 rs940031 chr8:8546848 C/T cg15556689 chr8:8085844 FLJ10661 -0.34 -8.89 -0.33 6.04e-18 Mood instability; BRCA cis rs4865169 0.783 rs7668814 chr4:57825190 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.31 8.14 0.31 2.09e-15 Breast cancer; BRCA cis rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05901451 chr6:126070800 HEY2 -0.7 -20.28 -0.63 5.55e-71 Brugada syndrome; BRCA cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg17366294 chr4:99064904 C4orf37 0.41 9.66 0.36 1.07e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs96067 0.772 rs6700737 chr1:36598214 A/G cg24686825 chr1:36642396 MAP7D1 -0.46 -8.33 -0.31 4.99e-16 Corneal structure; BRCA cis rs17095355 1.000 rs921348 chr10:111707498 A/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.86 -0.36 1.88e-21 Biliary atresia; BRCA cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.643 rs526134 chr2:219402371 G/A cg02176678 chr2:219576539 TTLL4 0.39 10.54 0.38 4.57e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs965469 0.779 rs6051770 chr20:3327014 A/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg05283184 chr6:79620031 NA 0.43 11.05 0.4 4.31e-26 Intelligence (multi-trait analysis); BRCA cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg04166393 chr7:2884313 GNA12 0.45 9.77 0.36 4.32e-21 Height; BRCA cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg19628046 chr18:33552617 C18orf21 0.53 10.64 0.39 1.83e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6598955 1.000 rs10902728 chr1:26598281 T/C cg04990556 chr1:26633338 UBXN11 0.78 17.1 0.56 2.79e-54 Obesity-related traits; BRCA cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs738322 0.726 rs5750561 chr22:38595260 A/T cg25457927 chr22:38595422 NA 0.51 21.86 0.65 1.55e-79 Cutaneous nevi; BRCA cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg09877947 chr5:131593287 PDLIM4 0.36 7.81 0.3 2.32e-14 Breast cancer; BRCA cis rs2742417 0.603 rs2064063 chr3:45759924 T/A cg04837898 chr3:45731254 SACM1L -0.4 -8.09 -0.3 3.07e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs7178424 0.817 rs12916052 chr15:62329382 A/G cg00456672 chr15:62358751 C2CD4A -0.36 -8.12 -0.31 2.46e-15 Height; BRCA cis rs7927592 0.913 rs7102898 chr11:68328870 G/A cg20283391 chr11:68216788 NA -0.46 -9.05 -0.34 1.66e-18 Total body bone mineral density; BRCA cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2742234 0.666 rs715106 chr10:43616751 C/A cg15436174 chr10:43711423 RASGEF1A -0.54 -10.63 -0.39 2.08e-24 Hirschsprung disease; BRCA cis rs9486719 0.895 rs12527021 chr6:97025496 C/T cg06623918 chr6:96969491 KIAA0776 -0.77 -13.77 -0.48 5.7800000000000005e-38 Migraine;Coronary artery disease; BRCA cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.68 0.5 2.94e-42 Motion sickness; BRCA cis rs4566357 0.595 rs10201538 chr2:227914449 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -8.2 -0.31 1.32e-15 Coronary artery disease; BRCA cis rs10044254 0.587 rs4568364 chr5:15732533 T/G cg07238450 chr5:15720153 FBXL7 -0.38 -8.04 -0.3 4.25e-15 Asthma (corticosteroid response); BRCA cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 3.93e-29 Bipolar disorder; BRCA cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg19678392 chr7:94953810 PON1 -0.43 -9.17 -0.34 6.48e-19 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.48 -9.43 -0.35 7.35e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs208520 0.690 rs207108 chr6:66794096 T/C cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.77 -11.77 -0.42 4.39e-29 Platelet count; BRCA cis rs6598955 0.671 rs10902732 chr1:26606174 A/C cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg03146154 chr1:46216737 IPP -0.44 -9.78 -0.36 3.68e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.72 15.11 0.51 2.44e-44 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9443645 0.509 rs9352668 chr6:79572678 A/G cg05283184 chr6:79620031 NA -0.35 -8.5 -0.32 1.29e-16 Intelligence (multi-trait analysis); BRCA cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg13298116 chr11:62369859 EML3;MTA2 -0.53 -10.72 -0.39 8.85e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs10206020 0.921 rs11884956 chr2:1566426 A/G cg26248373 chr2:1572462 NA -0.65 -15.46 -0.52 4.64e-46 IgG glycosylation; BRCA trans rs35110281 0.693 rs4819290 chr21:45122713 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.87 0.33 7.46e-18 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg13047869 chr3:10149882 C3orf24 0.52 10.86 0.39 2.54e-25 Alzheimer's disease; BRCA cis rs9393777 0.623 rs9358944 chr6:26469875 A/C cg12826209 chr6:26865740 GUSBL1 0.56 9.23 0.34 3.9e-19 Intelligence (multi-trait analysis); BRCA cis rs250677 0.522 rs6872701 chr5:148359086 C/G cg12140854 chr5:148520817 ABLIM3 0.42 8.56 0.32 8.45e-17 Breast cancer; BRCA cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.8 0.39 4.53e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.39e-16 Colorectal cancer; BRCA cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.21 0.56 7.75e-55 Bladder cancer; BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.73 10.58 0.39 3.33e-24 Platelet count; BRCA cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg23711669 chr6:146136114 FBXO30 -0.75 -18.0 -0.58 6.95e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs6570726 0.846 rs426874 chr6:145880630 A/C cg23711669 chr6:146136114 FBXO30 0.72 16.9 0.56 2.9e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.13 0.4 1.95e-26 Platelet count; BRCA cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs9818758 0.607 rs34784192 chr3:49274823 G/T cg00383909 chr3:49044727 WDR6 0.71 12.63 0.45 8.28e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs425277 0.606 rs262664 chr1:2083537 G/C cg04315214 chr1:2043799 PRKCZ -0.48 -12.65 -0.45 6.69e-33 Height; BRCA cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg06108461 chr20:60628389 TAF4 -0.98 -22.16 -0.66 3.66e-81 Body mass index; BRCA cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg11301795 chr4:187892539 NA -0.27 -8.71 -0.33 2.5e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg21918786 chr6:109611834 NA -0.44 -12.53 -0.44 2.34e-32 Reticulocyte fraction of red cells; BRCA cis rs10911232 0.507 rs10732271 chr1:183025898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.25e-51 Hypertriglyceridemia; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg22920501 chr2:26401640 FAM59B -0.9 -16.59 -0.55 1.12e-51 Gut microbiome composition (summer); BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22338127 chr1:209979572 IRF6 0.54 13.88 0.48 1.74e-38 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg02733842 chr7:1102375 C7orf50 -0.43 -8.64 -0.32 4.37e-17 Bronchopulmonary dysplasia; BRCA cis rs7512552 0.839 rs834232 chr1:150354682 T/C cg15654264 chr1:150340011 RPRD2 0.38 8.44 0.32 2.06e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg01579765 chr21:45077557 HSF2BP -0.37 -10.04 -0.37 3.85e-22 Mean corpuscular volume; BRCA cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.97 14.47 0.5 2.86e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7914558 1.000 rs7067970 chr10:104913870 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.61 0.39 2.52e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg12193833 chr17:30244370 NA -0.61 -9.77 -0.36 4.27e-21 Hip circumference adjusted for BMI; BRCA cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -8.11 -0.31 2.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs911119 1.000 rs13041070 chr20:23614261 G/A cg16589663 chr20:23618590 CST3 0.46 8.64 0.32 4.47e-17 Chronic kidney disease; BRCA cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg08885076 chr2:99613938 TSGA10 0.44 10.4 0.38 1.72e-23 Chronic sinus infection; BRCA cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg05665937 chr4:1216051 CTBP1 0.44 8.71 0.33 2.52e-17 Obesity-related traits; BRCA cis rs13095912 0.752 rs13092283 chr3:185338005 T/C cg11274856 chr3:185301563 NA 0.53 12.85 0.45 9.14e-34 Systolic blood pressure; BRCA cis rs36051895 0.632 rs12343038 chr9:5178579 A/G cg02405213 chr9:5042618 JAK2 0.47 9.07 0.34 1.5e-18 Pediatric autoimmune diseases; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg15112475 chr7:1198522 ZFAND2A -0.57 -12.95 -0.46 3.27e-34 Longevity;Endometriosis; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07256732 chr16:621771 PIGQ -0.34 -8.8 -0.33 1.3e-17 Height; BRCA trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg15704280 chr7:45808275 SEPT13 -0.77 -17.34 -0.57 1.8e-55 Coronary artery disease; BRCA trans rs11165623 0.564 rs11165658 chr1:96985670 A/G cg10631902 chr5:14652156 NA -0.46 -12.94 -0.46 3.67e-34 Hip circumference;Waist circumference; BRCA cis rs738321 0.725 rs9622738 chr22:38542346 G/A cg25457927 chr22:38595422 NA -0.38 -13.01 -0.46 1.67e-34 Breast cancer; BRCA cis rs3213545 0.659 rs2259693 chr12:121457995 G/A cg02403541 chr12:121454288 C12orf43 0.59 12.8 0.45 1.51e-33 Subjective well-being;Cardiovascular disease risk factors; BRCA cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg14349672 chr11:133703707 NA -0.34 -8.5 -0.32 1.34e-16 Childhood ear infection; BRCA cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.95 0.37 8.73e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9443189 0.526 rs10943255 chr6:76225928 T/A cg01950844 chr6:76311363 SENP6 0.85 13.6 0.47 3.36e-37 Prostate cancer; BRCA cis rs3125734 0.633 rs4979772 chr10:63967600 C/T cg09941381 chr10:64027924 RTKN2 0.29 8.73 0.33 2.23e-17 Rheumatoid arthritis; BRCA cis rs4308124 0.708 rs61358692 chr2:111965159 T/C cg04571233 chr2:111982156 NA -0.45 -9.71 -0.36 7.15e-21 Vitiligo; BRCA cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22590775 chr19:49891494 CCDC155 0.45 7.97 0.3 7.15e-15 Multiple sclerosis; BRCA cis rs2880765 0.835 rs4360874 chr15:86040820 A/T cg10818794 chr15:86012489 AKAP13 -0.31 -8.56 -0.32 8.11e-17 Coronary artery disease; BRCA cis rs4689388 0.791 rs1046317 chr4:6304242 T/C cg25554036 chr4:6271136 WFS1 0.44 9.25 0.34 3.34e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6558174 0.965 rs7831119 chr8:22489678 C/T cg03733263 chr8:22462867 KIAA1967 -0.42 -8.08 -0.3 3.2e-15 Breast cancer; BRCA cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg06784218 chr1:46089804 CCDC17 -0.43 -9.95 -0.37 8.5e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg09877947 chr5:131593287 PDLIM4 0.46 11.17 0.4 1.37e-26 Acylcarnitine levels; BRCA cis rs66530629 1.000 rs4601530 chr1:25044111 A/G cg01905478 chr1:25040257 NA -0.34 -7.97 -0.3 7.14e-15 Plateletcrit; BRCA trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg13010199 chr12:38710504 ALG10B 0.43 9.17 0.34 6.24e-19 Morning vs. evening chronotype; BRCA cis rs7246657 0.678 rs2972446 chr19:38129893 G/A cg18154014 chr19:37997991 ZNF793 -0.49 -9.24 -0.34 3.51e-19 Coronary artery calcification; BRCA cis rs262150 1.000 rs262149 chr7:158778256 A/G cg26536863 chr7:158807979 LOC154822 -0.34 -7.85 -0.3 1.77e-14 Facial morphology (factor 20); BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.71 0.42 8.19e-29 Tonsillectomy; BRCA cis rs2070488 0.931 rs6599212 chr3:38558906 T/C cg24069376 chr3:38537580 EXOG -0.41 -11.81 -0.42 2.95e-29 Electrocardiographic conduction measures; BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg11843238 chr5:131593191 PDLIM4 0.37 9.68 0.36 9.38e-21 Breast cancer; BRCA cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg16606324 chr3:10149918 C3orf24 0.56 9.97 0.37 7.35e-22 Alzheimer's disease; BRCA cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.46 8.6 0.32 5.96e-17 Multiple sclerosis; BRCA cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.63 -15.78 -0.53 1.3e-47 Multiple sclerosis; BRCA cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg00012203 chr2:219082015 ARPC2 -0.42 -8.11 -0.31 2.54e-15 Ulcerative colitis; BRCA trans rs637571 0.522 rs566590 chr11:65754062 C/T cg17712092 chr4:129076599 LARP1B 0.54 13.03 0.46 1.34e-34 Eosinophil percentage of white cells; BRCA cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg13256891 chr4:100009986 ADH5 0.37 8.05 0.3 4.05e-15 Alcohol dependence; BRCA cis rs7590368 1.000 rs7590368 chr2:10961474 T/C cg15705551 chr2:10952987 PDIA6 0.44 8.16 0.31 1.83e-15 Educational attainment (years of education); BRCA cis rs250677 0.522 rs919730 chr5:148352401 T/C cg12140854 chr5:148520817 ABLIM3 0.4 8.13 0.31 2.15e-15 Breast cancer; BRCA cis rs7246657 0.653 rs10414983 chr19:37665732 T/C cg18154014 chr19:37997991 ZNF793 0.55 9.25 0.34 3.46e-19 Coronary artery calcification; BRCA cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24531977 chr5:56204891 C5orf35 -0.88 -19.02 -0.6 2.83e-64 Initial pursuit acceleration; BRCA cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg11584989 chr19:19387371 SF4 0.67 14.73 0.5 1.78e-42 Bipolar disorder; BRCA cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.63 0.76 4.78e-122 Cognitive ability; BRCA cis rs6120849 0.754 rs752448 chr20:33592248 C/T cg24642439 chr20:33292090 TP53INP2 0.58 10.12 0.37 1.91e-22 Protein C levels; BRCA cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg06627557 chr7:32535165 LSM5;AVL9 -1.04 -28.95 -0.75 2.23e-118 Cognitive ability; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg22920501 chr2:26401640 FAM59B -0.66 -11.6 -0.42 2.35e-28 Gut microbiome composition (summer); BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg03609598 chr5:56110824 MAP3K1 -0.46 -8.03 -0.3 4.6e-15 Initial pursuit acceleration; BRCA cis rs9399135 0.967 rs1041481 chr6:135335063 G/A cg24558204 chr6:135376177 HBS1L 0.45 12.31 0.44 2.04e-31 Red blood cell count; BRCA cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.39 -0.44 9.24e-32 Type 2 diabetes; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg24642844 chr7:1081250 C7orf50 -0.58 -12.04 -0.43 3.04e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7799006 0.593 rs12531150 chr7:2289888 C/T cg08027265 chr7:2291960 NA -0.48 -12.74 -0.45 2.65e-33 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs861020 1.000 rs861020 chr1:209977111 A/G cg05527609 chr1:210001259 C1orf107 0.67 14.23 0.49 3.95e-40 Orofacial clefts; BRCA cis rs7769051 1.000 rs9493454 chr6:133144629 G/T cg07930552 chr6:133119739 C6orf192 -0.66 -10.4 -0.38 1.64e-23 Type 2 diabetes nephropathy; BRCA trans rs61931739 0.534 rs11053075 chr12:34207009 A/G cg26384229 chr12:38710491 ALG10B -0.66 -13.96 -0.48 7.69e-39 Morning vs. evening chronotype; BRCA cis rs9462027 0.583 rs7755982 chr6:34715297 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 8.03e-15 Systemic lupus erythematosus; BRCA cis rs2073300 1.000 rs12626013 chr20:23442215 G/A cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9533799 1.000 rs7999059 chr13:44807194 C/A cg19190762 chr13:44806055 NA 0.41 9.02 0.34 2.17e-18 Amyotrophic lateral sclerosis; BRCA cis rs490234 0.841 rs548793 chr9:128301931 C/T cg14078157 chr9:128172775 NA 0.34 8.11 0.31 2.63e-15 Mean arterial pressure; BRCA cis rs10493773 0.775 rs6667672 chr1:86171072 A/G cg17807903 chr1:86174739 ZNHIT6 -0.43 -9.5 -0.35 4.05e-20 Urate levels in overweight individuals; BRCA cis rs2832077 0.505 rs9305386 chr21:30386751 A/G cg03476357 chr21:30257390 N6AMT1 0.53 8.37 0.31 3.53e-16 Cognitive test performance; BRCA cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.46 -10.3 -0.38 3.92e-23 Aortic root size; BRCA cis rs7246657 0.765 rs4803262 chr19:38066760 G/A cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.29 0.61 1.07e-65 Smoking behavior; BRCA cis rs17270561 0.943 rs4478398 chr6:25694684 T/C cg17691542 chr6:26056736 HIST1H1C 0.63 11.04 0.4 4.86e-26 Iron status biomarkers; BRCA cis rs9790314 0.586 rs16832246 chr3:161109916 A/G cg03342759 chr3:160939853 NMD3 0.67 14.57 0.5 1.02e-41 Morning vs. evening chronotype; BRCA cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg00631329 chr6:26305371 NA -0.43 -12.71 -0.45 3.53e-33 Educational attainment; BRCA cis rs4853036 0.951 rs61422548 chr2:70110249 G/T cg02498382 chr2:70120550 SNRNP27 -0.56 -10.14 -0.37 1.6e-22 Colorectal or endometrial cancer; BRCA cis rs7617773 0.743 rs11716371 chr3:48362750 C/T cg11946769 chr3:48343235 NME6 0.67 13.64 0.47 2.37e-37 Coronary artery disease; BRCA cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 11.31 0.41 3.81e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg04546413 chr19:29218101 NA 0.63 12.77 0.45 1.98e-33 Methadone dose in opioid dependence; BRCA cis rs11098499 1.000 rs11098499 chr4:120187611 C/T cg09307838 chr4:120376055 NA 0.64 13.09 0.46 7.25e-35 Corneal astigmatism; BRCA cis rs1372520 0.873 rs2583990 chr4:90771499 A/G cg15133208 chr4:90757351 SNCA -0.38 -7.93 -0.3 9.7e-15 Neuroticism; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 18.0 0.58 6.37e-59 Platelet count; BRCA trans rs5756813 1.000 rs5756813 chr22:38175477 A/C cg19894588 chr14:64061835 NA -0.52 -13.63 -0.47 2.68e-37 Optic cup area;Vertical cup-disc ratio; BRCA trans rs75804782 0.572 rs56330821 chr2:239273949 C/T cg01134436 chr17:81009848 B3GNTL1 0.75 7.98 0.3 6.64e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18765753 chr7:1198926 ZFAND2A -0.36 -8.8 -0.33 1.26e-17 Longevity;Endometriosis; BRCA cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.61 12.69 0.45 4.45e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs12540874 0.507 rs4947644 chr7:50618876 C/T cg18232548 chr7:50535776 DDC 0.36 8.7 0.33 2.9e-17 Systemic sclerosis; BRCA cis rs6964587 1.000 rs13239875 chr7:91716104 G/A cg17063962 chr7:91808500 NA 0.54 12.71 0.45 3.83e-33 Breast cancer; BRCA cis rs11059919 1 rs11059919 chr12:129289190 G/A cg09035930 chr12:129282057 SLC15A4 0.57 16.81 0.55 8.83e-53 Systemic lupus erythematosus; BRCA cis rs561341 1.000 rs7214017 chr17:30332220 T/C cg23018236 chr17:30244563 NA -0.46 -8.29 -0.31 6.9e-16 Hip circumference adjusted for BMI; BRCA cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg06115741 chr20:33292138 TP53INP2 0.51 11.12 0.4 2.13e-26 Coronary artery disease; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg27588902 chr6:42928151 GNMT -0.3 -10.14 -0.37 1.7e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs758324 0.947 rs60847707 chr5:131252554 C/T cg06307176 chr5:131281290 NA -0.52 -10.15 -0.37 1.56e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg01483505 chr11:975446 AP2A2 0.33 9.14 0.34 7.87e-19 Alzheimer's disease (late onset); BRCA cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg21535247 chr6:8435926 SLC35B3 0.41 9.38 0.35 1.09e-19 Motion sickness; BRCA cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg13256891 chr4:100009986 ADH5 0.51 9.77 0.36 4.23e-21 Smoking initiation; BRCA cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg20607287 chr7:12443886 VWDE -0.58 -8.36 -0.31 4.04e-16 Coronary artery disease; BRCA cis rs10751667 0.580 rs7396041 chr11:1001607 G/A cg06064525 chr11:970664 AP2A2 -0.29 -8.42 -0.32 2.43e-16 Alzheimer's disease (late onset); BRCA trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg23533926 chr12:111358616 MYL2 -0.41 -8.57 -0.32 7.8e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.67 -0.32 3.43e-17 Glomerular filtration rate (creatinine); BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg08742575 chr21:47604166 C21orf56 0.41 8.23 0.31 1.02e-15 Testicular germ cell tumor; BRCA cis rs758324 0.947 rs7734536 chr5:131162124 C/T cg06307176 chr5:131281290 NA 0.52 10.16 0.37 1.42e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs10927875 0.632 rs2862162 chr1:16142960 A/C cg21385522 chr1:16154831 NA 0.99 25.46 0.71 3.02e-99 Dilated cardiomyopathy; BRCA cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.68e-24 Motion sickness; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 2e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg22907277 chr7:1156413 C7orf50 0.45 10.27 0.38 5.21e-23 Longevity;Endometriosis; BRCA cis rs921968 0.541 rs832798 chr2:219464810 G/A cg10223061 chr2:219282414 VIL1 -0.28 -8.32 -0.31 5.35e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs7246657 0.524 rs28542490 chr19:37456584 C/A cg14683738 chr19:37701593 ZNF585B 0.5 7.88 0.3 1.43e-14 Coronary artery calcification; BRCA cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg20503657 chr10:835505 NA 1.04 18.38 0.59 7.04e-61 Eosinophil percentage of granulocytes; BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg00149659 chr3:10157352 C3orf10 0.8 13.69 0.48 1.4e-37 Alzheimer's disease; BRCA trans rs7618501 0.521 rs2352984 chr3:49948728 T/C cg21659725 chr3:3221576 CRBN 0.34 8.26 0.31 8.32e-16 Intelligence (multi-trait analysis); BRCA cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg11845111 chr2:191398756 TMEM194B 0.4 9.34 0.35 1.55e-19 Pulse pressure; BRCA cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg25767906 chr1:53392781 SCP2 0.34 7.83 0.3 2.09e-14 Monocyte count; BRCA cis rs17401966 0.838 rs2182326 chr1:10385664 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.76 0.48 6.16e-38 Hepatocellular carcinoma; BRCA cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg13319975 chr6:146136371 FBXO30 -0.48 -11.53 -0.41 4.63e-28 Lobe attachment (rater-scored or self-reported); BRCA trans rs7200543 1.000 rs2740 chr16:15132108 A/G cg24683922 chr1:11983373 KIAA2013 -0.38 -8.47 -0.32 1.65e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -14.97 -0.51 1.18e-43 Initial pursuit acceleration; BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -9.79 -0.36 3.53e-21 Renal function-related traits (BUN); BRCA cis rs832540 0.552 rs702681 chr5:56218029 C/T cg12311346 chr5:56204834 C5orf35 -0.49 -9.92 -0.37 1.14e-21 Coronary artery disease; BRCA cis rs6964587 0.655 rs6465351 chr7:91773213 T/C cg17063962 chr7:91808500 NA 0.57 13.25 0.46 1.44e-35 Breast cancer; BRCA cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg16405210 chr4:1374714 KIAA1530 -0.37 -7.83 -0.3 2e-14 Obesity-related traits; BRCA cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg03351412 chr1:154909251 PMVK 0.62 14.22 0.49 4.73e-40 Prostate cancer; BRCA trans rs629535 0.783 rs658407 chr8:70035247 T/C cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs9814567 1.000 rs13090969 chr3:134307257 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.63 0.61 1.63e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg23788917 chr6:8435910 SLC35B3 -0.49 -10.6 -0.39 2.78e-24 Motion sickness; BRCA cis rs9914988 0.943 rs4794839 chr17:27131393 G/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs782590 0.967 rs17278044 chr2:55748217 G/C cg18811423 chr2:55921094 PNPT1 0.73 23.39 0.68 7.41e-88 Metabolic syndrome; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg09436375 chr6:42928200 GNMT 0.28 10.85 0.39 2.63e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.34 0.41 2.79e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.92 0.3 1.08e-14 Melanoma; BRCA cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs858239 0.601 rs987257 chr7:23147840 G/A cg23682824 chr7:23144976 KLHL7 0.42 10.94 0.4 1.16e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg00531865 chr16:30841666 NA -0.49 -11.56 -0.42 3.47e-28 Multiple myeloma; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26314531 chr2:26401878 FAM59B -0.67 -11.99 -0.43 4.89e-30 Gut microbiome composition (summer); BRCA cis rs7927771 0.965 rs3817335 chr11:47643891 T/A cg18512352 chr11:47633146 NA -0.36 -8.86 -0.33 7.89e-18 Subjective well-being; BRCA cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg05472934 chr7:22766657 IL6 0.49 12.69 0.45 4.44e-33 Lung cancer; BRCA cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg17366294 chr4:99064904 C4orf37 0.42 9.73 0.36 5.8e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs9864346 chr3:134312352 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.52 -0.61 6.62e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05039488 chr6:79577232 IRAK1BP1 0.36 7.85 0.3 1.78e-14 Endometrial cancer; BRCA cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.54 0.38 4.59e-24 IgG glycosylation; BRCA cis rs10883723 0.810 rs2296590 chr10:104262628 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.91 0.62 5.12e-69 Allergic disease (asthma, hay fever or eczema); BRCA cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.29e-45 Aortic root size; BRCA trans rs2262909 0.962 rs409835 chr19:22230671 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -7.98 -0.3 6.96e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs775227 0.574 rs16860849 chr3:113049993 C/T cg18753928 chr3:113234510 CCDC52 0.54 9.24 0.34 3.54e-19 Dental caries; BRCA cis rs10751667 0.961 rs7395303 chr11:986221 T/A cg06064525 chr11:970664 AP2A2 -0.34 -10.11 -0.37 2.16e-22 Alzheimer's disease (late onset); BRCA cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg02503808 chr4:7069936 GRPEL1 -0.81 -15.52 -0.52 2.51e-46 Monocyte percentage of white cells; BRCA cis rs1568889 1.000 rs12797712 chr11:28290890 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 12.84 0.45 1.03e-33 Bipolar disorder; BRCA cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg11843238 chr5:131593191 PDLIM4 0.38 9.32 0.35 1.92e-19 Acylcarnitine levels; BRCA trans rs637571 0.544 rs12361552 chr11:65701204 G/A cg17712092 chr4:129076599 LARP1B -0.59 -14.32 -0.49 1.5e-40 Eosinophil percentage of white cells; BRCA cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 11.54 0.42 3.94e-28 Height; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg27071517 chr21:31768726 KRTAP13-1 0.3 7.95 0.3 8.5e-15 HDL cholesterol; BRCA cis rs877529 0.966 rs5995688 chr22:39548027 A/G cg12193277 chr22:39547181 CBX7 0.45 12.31 0.44 2.14e-31 Multiple myeloma; BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.32 -0.44 1.9e-31 Alzheimer's disease; BRCA cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg13319975 chr6:146136371 FBXO30 -0.62 -14.5 -0.5 2.1e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg00684032 chr4:1343700 KIAA1530 0.53 12.44 0.44 5.63e-32 Obesity-related traits; BRCA cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs34172651 0.687 rs8044992 chr16:24811207 T/C cg04756594 chr16:24857601 SLC5A11 0.33 8.32 0.31 5.51e-16 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg04025307 chr7:1156635 C7orf50 0.48 10.12 0.37 1.98e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11098499 0.708 rs11732686 chr4:120252330 C/A cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs11252926 0.574 rs10904065 chr10:423226 G/T cg18196295 chr10:418757 DIP2C -0.61 -12.68 -0.45 4.9e-33 Psychosis in Alzheimer's disease; BRCA cis rs875971 0.545 rs3735147 chr7:65970528 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.89 0.36 1.45e-21 Aortic root size; BRCA cis rs10465746 0.775 rs4907186 chr1:84340753 G/T cg10977910 chr1:84465055 TTLL7 0.63 13.33 0.47 6.17e-36 Obesity-related traits; BRCA cis rs12612619 0.579 rs13029206 chr2:27077610 G/A cg12368169 chr2:27073192 DPYSL5 -0.33 -10.04 -0.37 3.85e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs13315871 1.000 rs9860970 chr3:58353781 C/T cg20936604 chr3:58311152 NA -0.62 -7.96 -0.3 8.01e-15 Cholesterol, total; BRCA cis rs62229266 0.804 rs2835263 chr21:37430245 A/G cg12218747 chr21:37451666 NA 0.33 7.95 0.3 8.37e-15 Mitral valve prolapse; BRCA cis rs897984 0.520 rs4889614 chr16:30862135 G/A cg02466173 chr16:30829666 NA 0.47 9.42 0.35 8.31e-20 Dementia with Lewy bodies; BRCA cis rs3806843 0.900 rs2563286 chr5:140125199 T/A cg16179182 chr5:140090404 VTRNA1-1 0.4 9.28 0.34 2.64e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 15.04 0.51 5.48e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs881375 0.933 rs1548784 chr9:123685280 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.76 0.39 6.33e-25 Rheumatoid arthritis; BRCA cis rs1994135 0.594 rs10772096 chr12:33732869 A/G cg06521331 chr12:34319734 NA -0.39 -8.06 -0.3 3.7e-15 Resting heart rate; BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.61 -11.2 -0.41 1e-26 Alzheimer's disease; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg22907277 chr7:1156413 C7orf50 0.6 11.68 0.42 1.07e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs736408 0.812 rs2071507 chr3:52826707 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 7.89 0.3 1.36e-14 Bipolar disorder; BRCA cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.3 -0.31 6.42e-16 Bipolar disorder; BRCA cis rs2073300 0.609 rs3746733 chr20:23349749 C/T cg12062639 chr20:23401060 NAPB 0.91 13.46 0.47 1.54e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2832077 0.506 rs2832085 chr21:30155258 G/T cg24692254 chr21:30365293 RNF160 -0.47 -9.83 -0.36 2.59e-21 Cognitive test performance; BRCA cis rs752010 0.841 rs11210498 chr1:42077958 T/G cg06885757 chr1:42089581 HIVEP3 0.23 8.49 0.32 1.43e-16 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg17470723 chr8:74884337 TCEB1 0.4 8.72 0.33 2.46e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.52 0.41 4.72e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2404602 0.647 rs12904417 chr15:76964152 A/G cg23625390 chr15:77176239 SCAPER 0.57 14.55 0.5 1.2e-41 Blood metabolite levels; BRCA cis rs142518269 1 rs142518269 chr2:24087095 G/A cg08917208 chr2:24149416 ATAD2B 1.1 15.43 0.52 6.58e-46 Mean corpuscular hemoglobin; BRCA cis rs9287719 0.967 rs728282 chr2:10750303 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg23422044 chr7:1970798 MAD1L1 -0.59 -10.69 -0.39 1.18e-24 Bipolar disorder; BRCA cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg07395648 chr5:131743802 NA -0.36 -9.11 -0.34 1.03e-18 Blood metabolite levels; BRCA cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg26031613 chr14:104095156 KLC1 -0.43 -8.53 -0.32 1.04e-16 Schizophrenia; BRCA cis rs7408868 0.908 rs2074619 chr19:15276919 G/A cg14696996 chr19:15285081 NOTCH3 0.99 14.49 0.5 2.35e-41 Pulse pressure; BRCA cis rs8062405 1.000 rs7198606 chr16:28875122 T/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs61931739 0.534 rs11052959 chr12:33997095 T/C cg06521331 chr12:34319734 NA -0.62 -11.13 -0.4 2.05e-26 Morning vs. evening chronotype; BRCA cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg24692254 chr21:30365293 RNF160 -0.62 -15.86 -0.53 5.18e-48 Dental caries; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg14004847 chr7:1930337 MAD1L1 -0.46 -8.87 -0.33 7.52e-18 Bipolar disorder and schizophrenia; BRCA cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg26384229 chr12:38710491 ALG10B 0.72 17.02 0.56 7.88e-54 Bladder cancer; BRCA cis rs10080237 0.564 rs2490230 chr6:80812464 G/A cg08355045 chr6:80787529 NA 0.42 10.96 0.4 9.49e-26 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; BRCA cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs920590 0.758 rs35280191 chr8:19665214 A/C cg03894339 chr8:19674705 INTS10 0.44 8.62 0.32 5.34e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs708547 0.647 rs1718839 chr4:57827206 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.41 -7.99 -0.3 6.34e-15 Response to bleomycin (chromatid breaks); BRCA cis rs9560113 1.000 rs4771757 chr13:112176379 G/T cg10483660 chr13:112241077 NA 0.32 7.93 0.3 9.77e-15 Menarche (age at onset); BRCA cis rs6977660 0.714 rs4721827 chr7:19825655 A/G cg05791153 chr7:19748676 TWISTNB 0.59 11.0 0.4 6.53e-26 Thyroid stimulating hormone; BRCA cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg14664628 chr15:75095509 CSK -0.74 -18.23 -0.58 4.43e-60 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs473651 0.935 rs477041 chr2:239355995 C/G cg21699342 chr2:239360505 ASB1 -0.54 -14.56 -0.5 1.09e-41 Multiple system atrophy; BRCA cis rs8010715 0.816 rs8015168 chr14:24599872 A/T cg23112188 chr14:24563095 PCK2 -0.32 -8.11 -0.31 2.52e-15 IgG glycosylation; BRCA cis rs7809950 0.648 rs114452520 chr7:107176780 C/T cg23024343 chr7:107201750 COG5 -0.41 -9.36 -0.35 1.29e-19 Coronary artery disease; BRCA cis rs9341808 0.621 rs2322627 chr6:80806341 T/A cg08355045 chr6:80787529 NA 0.46 12.07 0.43 2.31e-30 Sitting height ratio; BRCA cis rs2882667 0.690 rs288032 chr5:138215328 G/A cg04439458 chr5:138467593 SIL1 -0.35 -8.56 -0.32 8.34e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs11088226 0.681 rs2833912 chr21:33949822 G/A cg09050820 chr6:167586206 TCP10L2 0.85 15.88 0.53 4.06e-48 Gastritis; BRCA cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg10802521 chr3:52805072 NEK4 -0.34 -9.28 -0.34 2.61e-19 Bipolar disorder; BRCA cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg02297831 chr4:17616191 MED28 0.36 8.43 0.32 2.25e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg05623727 chr3:50126028 RBM5 -0.43 -10.03 -0.37 4.47e-22 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.36 -0.44 1.25e-31 Lymphocyte counts; BRCA cis rs6840360 0.554 rs62329088 chr4:152471289 C/T cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg01579765 chr21:45077557 HSF2BP -0.4 -9.94 -0.37 9.47e-22 Mean corpuscular volume; BRCA cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg12641515 chr19:46296257 DMWD -0.53 -11.76 -0.42 5.01e-29 Coronary artery disease; BRCA cis rs7914558 0.901 rs1926034 chr10:104829102 G/A cg04362960 chr10:104952993 NT5C2 0.42 10.1 0.37 2.41e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg12927641 chr6:109611667 NA -0.41 -10.54 -0.38 4.76e-24 Reticulocyte fraction of red cells; BRCA cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.36 0.35 1.33e-19 Menopause (age at onset); BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg05896524 chr21:47604654 C21orf56 0.5 9.82 0.36 2.75e-21 Testicular germ cell tumor; BRCA cis rs3125734 0.660 rs10733769 chr10:63974255 G/T cg19640130 chr10:64028056 RTKN2 -0.31 -8.95 -0.33 3.93e-18 Rheumatoid arthritis; BRCA cis rs9341808 0.754 rs9361591 chr6:80953255 C/A cg08355045 chr6:80787529 NA 0.39 9.92 0.37 1.17e-21 Sitting height ratio; BRCA cis rs2731664 0.792 rs2630764 chr5:176880085 C/T cg23176889 chr5:176863531 GRK6 -0.62 -17.02 -0.56 7.68e-54 Intelligence (multi-trait analysis); BRCA trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg10578991 chr7:12443926 VWDE -0.54 -8.1 -0.31 2.87e-15 Coronary artery disease; BRCA cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg20742385 chr13:113633654 MCF2L -0.37 -7.86 -0.3 1.6e-14 Systolic blood pressure; BRCA cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg13010199 chr12:38710504 ALG10B 0.41 8.34 0.31 4.59e-16 Morning vs. evening chronotype; BRCA cis rs4268898 1.000 rs10165445 chr2:24441698 C/T cg06627628 chr2:24431161 ITSN2 0.5 10.43 0.38 1.31e-23 Asthma; BRCA cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg24642439 chr20:33292090 TP53INP2 0.56 12.3 0.44 2.43e-31 Coronary artery disease; BRCA cis rs514406 0.708 rs536621 chr1:53309097 A/G cg08859206 chr1:53392774 SCP2 -0.59 -12.81 -0.45 1.39e-33 Monocyte count; BRCA cis rs3762637 0.941 rs7653592 chr3:122218371 G/A cg24169773 chr3:122142474 KPNA1 -0.43 -8.04 -0.3 4.23e-15 LDL cholesterol levels; BRCA cis rs2742234 0.541 rs11238483 chr10:43728780 A/G cg02780029 chr10:43622663 RET 0.35 7.85 0.3 1.71e-14 Hirschsprung disease; BRCA cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.4e-64 Cognitive function; BRCA cis rs27434 0.583 rs149544 chr5:96157854 C/G cg16492584 chr5:96139282 ERAP1 -0.5 -12.76 -0.45 2.31e-33 Ankylosing spondylitis; BRCA cis rs896854 0.902 rs726816 chr8:95968413 T/G cg16049864 chr8:95962084 TP53INP1 -0.49 -12.22 -0.44 5.1e-31 Type 2 diabetes; BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg20476274 chr7:133979776 SLC35B4 0.61 15.56 0.52 1.52e-46 Mean platelet volume; BRCA cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA trans rs1997103 1.000 rs9642578 chr7:55400320 A/G cg20935933 chr6:143382018 AIG1 0.6 11.38 0.41 1.95e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.4 8.09 0.3 3.04e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9633740 1.000 rs7097656 chr10:82250831 T/C cg00277334 chr10:82204260 NA -0.48 -7.89 -0.3 1.27e-14 Post bronchodilator FEV1; BRCA trans rs629535 0.814 rs545720 chr8:70063370 T/C cg21567404 chr3:27674614 NA 1.01 20.66 0.63 4.98e-73 Dupuytren's disease; BRCA cis rs11971779 0.680 rs28579232 chr7:139073116 C/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg21644426 chr2:191273491 MFSD6 -0.42 -10.56 -0.39 3.77e-24 Pulse pressure; BRCA cis rs11785693 0.862 rs11778367 chr8:4988398 T/C cg26367366 chr8:4980734 NA 0.61 10.99 0.4 7.38e-26 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg11266682 chr4:10021025 SLC2A9 0.47 12.52 0.44 2.61e-32 Bone mineral density; BRCA cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.12 0.37 1.97e-22 Aortic root size; BRCA cis rs7246657 0.722 rs35863684 chr19:38109777 C/T cg23950597 chr19:37808831 NA -0.49 -8.41 -0.32 2.74e-16 Coronary artery calcification; BRCA cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg14784868 chr12:69753453 YEATS4 0.66 19.14 0.6 6.6e-65 Blood protein levels; BRCA cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg06238570 chr21:40685208 BRWD1 -0.39 -7.98 -0.3 6.8e-15 Menarche (age at onset); BRCA trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.54 17.21 0.56 7.98e-55 Intelligence (multi-trait analysis); BRCA cis rs9473147 0.543 rs9296559 chr6:47452270 T/C cg12968598 chr6:47444699 CD2AP 0.45 9.6 0.36 1.72e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs2282802 0.711 rs3777095 chr5:139660916 G/A cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.15e-15 Intelligence (multi-trait analysis); BRCA cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg06212747 chr3:49208901 KLHDC8B -0.57 -10.72 -0.39 8.98e-25 Menarche (age at onset); BRCA cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg08885076 chr2:99613938 TSGA10 -0.6 -13.13 -0.46 4.92e-35 Chronic sinus infection; BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg07930192 chr7:1003750 NA 0.4 8.69 0.33 3.03e-17 Longevity;Endometriosis; BRCA cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg08999081 chr20:33150536 PIGU -0.34 -8.23 -0.31 1.07e-15 Coronary artery disease; BRCA cis rs1865721 1.000 rs62089507 chr18:73179019 C/T cg26385618 chr18:73139727 C18orf62 -0.41 -9.23 -0.34 3.87e-19 Intelligence; BRCA cis rs11229555 0.645 rs11229435 chr11:58185796 G/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs11893307 0.566 rs10170782 chr2:191623236 G/A cg05765582 chr2:191677683 NA 0.48 8.46 0.32 1.8e-16 Mean platelet volume; BRCA cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.54 0.38 4.58e-24 Motion sickness; BRCA cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.39 0.44 9.76e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9814567 1.000 rs13087875 chr3:134261123 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.47e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6840360 0.571 rs11931934 chr4:152552082 A/G cg22705602 chr4:152727874 NA -0.34 -8.38 -0.31 3.27e-16 Intelligence (multi-trait analysis); BRCA cis rs1035144 0.510 rs12432357 chr14:81299468 A/G cg06600135 chr14:81408086 NA -0.51 -12.37 -0.44 1.11e-31 Male sexual orientation; BRCA cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg26536863 chr7:158807979 LOC154822 0.37 8.59 0.32 6.8e-17 Facial morphology (factor 20); BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg05347473 chr6:146136440 FBXO30 0.42 8.37 0.31 3.6e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2625529 0.652 rs8036307 chr15:72175120 A/G cg16672083 chr15:72433130 SENP8 0.66 15.83 0.53 7.13e-48 Red blood cell count; BRCA cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg08085267 chr17:45401833 C17orf57 0.6 12.26 0.44 3.56e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7927771 0.524 rs10838771 chr11:47831332 A/G cg20307385 chr11:47447363 PSMC3 -0.38 -8.84 -0.33 9.34e-18 Subjective well-being; BRCA cis rs6748734 0.817 rs10182575 chr2:241806690 C/T cg07537917 chr2:241836409 C2orf54 -0.43 -10.41 -0.38 1.46e-23 Urinary metabolites; BRCA cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg07395648 chr5:131743802 NA -0.36 -7.99 -0.3 6.34e-15 Breast cancer; BRCA cis rs858239 0.600 rs6461691 chr7:23139345 G/A cg23682824 chr7:23144976 KLHL7 0.43 11.39 0.41 1.68e-27 Cerebrospinal fluid biomarker levels; BRCA trans rs61931739 0.534 rs7310499 chr12:34212112 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.35 0.49 1.15e-40 Morning vs. evening chronotype; BRCA cis rs7267979 0.966 rs416745 chr20:25438868 T/C cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6456156 0.792 rs4710183 chr6:167514083 A/G cg07741184 chr6:167504864 NA -0.31 -9.03 -0.34 2.05e-18 Primary biliary cholangitis; BRCA cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg13010199 chr12:38710504 ALG10B 0.35 8.5 0.32 1.35e-16 Morning vs. evening chronotype; BRCA trans rs9291683 0.588 rs17246745 chr4:9994583 T/C cg26043149 chr18:55253948 FECH 0.4 8.89 0.33 6.3e-18 Bone mineral density; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg25036284 chr2:26402008 FAM59B -0.9 -15.25 -0.52 5.18e-45 Gut microbiome composition (summer); BRCA cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg24006582 chr15:45444508 DUOX1 0.56 10.9 0.4 1.72e-25 Uric acid levels; BRCA cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg24642439 chr20:33292090 TP53INP2 -0.52 -11.42 -0.41 1.3e-27 Glomerular filtration rate (creatinine); BRCA cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg06484146 chr7:12443880 VWDE -0.63 -9.88 -0.36 1.66e-21 Coronary artery disease; BRCA trans rs208520 0.690 rs12208977 chr6:66725257 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 20.36 0.63 1.98e-71 Exhaled nitric oxide output; BRCA cis rs10992471 0.528 rs3780347 chr9:95266812 A/G cg14631576 chr9:95140430 CENPP -0.34 -8.63 -0.32 5.02e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg03146154 chr1:46216737 IPP -0.51 -11.26 -0.41 5.93e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.4 -0.32 2.86e-16 Total body bone mineral density; BRCA trans rs1200821 0.738 rs1926128 chr10:37654620 C/T cg25427524 chr10:38739819 LOC399744 0.38 8.02 0.3 4.91e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs17601876 0.651 rs12907866 chr15:51545454 A/G cg19946085 chr15:51559439 CYP19A1 -0.33 -8.76 -0.33 1.72e-17 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg17724175 chr1:150552817 MCL1 0.26 8.54 0.32 9.54e-17 Tonsillectomy; BRCA cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg26373071 chr5:1325741 CLPTM1L 0.46 10.98 0.4 8.49e-26 Lung cancer; BRCA cis rs736408 0.561 rs2276815 chr3:52853747 C/G cg11645453 chr3:52864694 ITIH4 0.42 10.33 0.38 2.99e-23 Bipolar disorder; BRCA cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.68 -0.36 8.95e-21 Alzheimer's disease (late onset); BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18765753 chr7:1198926 ZFAND2A -0.52 -13.3 -0.47 7.98e-36 Longevity;Endometriosis; BRCA cis rs2836950 0.545 rs2836922 chr21:40516308 C/T cg17971929 chr21:40555470 PSMG1 -0.46 -9.93 -0.37 1.06e-21 Menarche (age at onset); BRCA cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg19628046 chr18:33552617 C18orf21 0.61 12.03 0.43 3.33e-30 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg22972055 chr7:872293 UNC84A 0.39 8.76 0.33 1.68e-17 Cerebrospinal P-tau181p levels; BRCA trans rs2204008 0.652 rs11520002 chr12:38022179 G/T cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.55e-21 Bladder cancer; BRCA cis rs5758511 0.680 rs5758681 chr22:42645091 A/G cg00645731 chr22:42541494 CYP2D7P1 0.51 9.91 0.37 1.2e-21 Birth weight; BRCA cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg05868516 chr6:26286170 HIST1H4H 0.51 11.15 0.4 1.6e-26 Educational attainment; BRCA cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.83 -0.39 3.4e-25 Personality dimensions; BRCA cis rs28374715 0.733 rs9568 chr15:41573612 G/T cg18705301 chr15:41695430 NDUFAF1 -0.85 -18.46 -0.59 2.55e-61 Ulcerative colitis; BRCA cis rs6840360 0.571 rs4696101 chr4:152528513 A/G cg22705602 chr4:152727874 NA -0.32 -8.14 -0.31 2.04e-15 Intelligence (multi-trait analysis); BRCA cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg11941060 chr3:133502564 NA -0.34 -8.13 -0.31 2.19e-15 Iron status biomarkers; BRCA cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg06618935 chr21:46677482 NA -0.37 -8.05 -0.3 4.1e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs68170813 0.523 rs7777976 chr7:106888594 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.44 -0.32 2.05e-16 Coronary artery disease; BRCA cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg13770153 chr20:60521292 NA -0.39 -9.14 -0.34 8.52e-19 Body mass index; BRCA cis rs3824867 0.920 rs3740685 chr11:47468791 C/T cg20307385 chr11:47447363 PSMC3 0.55 12.1 0.43 1.7e-30 Mean corpuscular hemoglobin; BRCA cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg07636037 chr3:49044803 WDR6 0.98 28.75 0.75 2.78e-117 Parkinson's disease; BRCA cis rs35306767 0.623 rs72760943 chr10:1143104 G/A cg20503657 chr10:835505 NA 0.67 10.78 0.39 5.07e-25 Eosinophil percentage of granulocytes; BRCA trans rs61931739 0.517 rs2636073 chr12:34063049 C/T cg26384229 chr12:38710491 ALG10B 0.52 11.18 0.4 1.28e-26 Morning vs. evening chronotype; BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg00106254 chr7:1943704 MAD1L1 -0.45 -12.42 -0.44 6.93e-32 Autism spectrum disorder or schizophrenia; BRCA cis rs6785206 0.667 rs2253125 chr3:128329793 T/C cg16766828 chr3:128327626 NA -0.68 -11.07 -0.4 3.42e-26 Lymphocyte percentage of white cells; BRCA cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg05552183 chr6:42928497 GNMT -0.63 -11.02 -0.4 5.71e-26 Blood protein levels; BRCA cis rs8180040 0.966 rs3736177 chr3:47451411 C/T cg27129171 chr3:47204927 SETD2 -0.69 -16.06 -0.54 5.07e-49 Colorectal cancer; BRCA trans rs208515 0.525 rs10498841 chr6:66663706 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.83 15.72 0.53 2.52e-47 Exhaled nitric oxide levels; BRCA cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg26677194 chr12:130822605 PIWIL1 0.6 14.47 0.5 2.92e-41 Menopause (age at onset); BRCA cis rs56104184 0.775 rs17272700 chr19:49391770 G/A cg21252483 chr19:49399788 TULP2 -0.52 -11.06 -0.4 4.04e-26 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.69 0.36 8.27e-21 Lung cancer in ever smokers; BRCA cis rs250677 0.522 rs6580590 chr5:148360374 C/T cg12140854 chr5:148520817 ABLIM3 0.41 8.32 0.31 5.16e-16 Breast cancer; BRCA cis rs1577917 0.538 rs7755996 chr6:86423720 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 12.63 0.45 8.24e-33 Response to antipsychotic treatment; BRCA cis rs3806843 1.000 rs1548701 chr5:140164557 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.67e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -9.64 -0.36 1.29e-20 HDL cholesterol; BRCA cis rs7254827 0.784 rs8108205 chr19:17220341 G/A cg19418318 chr19:17219073 MYO9B -0.51 -10.32 -0.38 3.34e-23 Mean platelet volume; BRCA cis rs758324 0.947 rs600661 chr5:131290894 T/C cg06307176 chr5:131281290 NA -0.53 -10.4 -0.38 1.68e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg22800045 chr5:56110881 MAP3K1 0.66 12.27 0.44 3.09e-31 Type 2 diabetes; BRCA cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg05084668 chr3:125655381 ALG1L -0.48 -8.33 -0.31 4.83e-16 Blood pressure (smoking interaction); BRCA cis rs929596 0.785 rs17862875 chr2:234649302 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -12.17 -0.43 8.46e-31 Total bilirubin levels in HIV-1 infection; BRCA cis rs7020830 0.571 rs3780335 chr9:37376587 A/G cg14294708 chr9:37120828 ZCCHC7 -0.86 -16.25 -0.54 6.09e-50 Schizophrenia; BRCA cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg16339924 chr4:17578868 LAP3 0.63 15.92 0.53 2.55e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs36051895 0.622 rs10974952 chr9:5079828 A/T cg02405213 chr9:5042618 JAK2 -0.55 -9.59 -0.35 2e-20 Pediatric autoimmune diseases; BRCA cis rs4321325 0.733 rs79208542 chr2:127935686 G/C cg11380483 chr2:127933992 NA 0.44 8.48 0.32 1.56e-16 Protein C levels; BRCA cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg26384229 chr12:38710491 ALG10B 0.66 15.56 0.52 1.65e-46 Bladder cancer; BRCA cis rs8058578 1.000 rs67128646 chr16:30672097 A/C cg02466173 chr16:30829666 NA -0.49 -10.08 -0.37 2.82e-22 Multiple myeloma; BRCA cis rs17270561 0.583 rs6937800 chr6:25765943 A/G cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs1891275 0.508 rs7099557 chr10:93445364 C/G cg07889827 chr10:93443413 NA -0.44 -12.37 -0.44 1.2e-31 Intelligence (multi-trait analysis); BRCA cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg18904891 chr8:8559673 CLDN23 0.58 11.29 0.41 4.28e-27 Obesity-related traits; BRCA cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg12011299 chr4:100065546 ADH4 0.42 10.42 0.38 1.34e-23 Alcohol dependence; BRCA cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg08601574 chr20:25228251 PYGB -0.34 -8.06 -0.3 3.77e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12611088 0.571 rs2599447 chr19:44007012 G/A cg15012607 chr19:44012195 ETHE1 -0.35 -9.11 -0.34 1.08e-18 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg09177884 chr7:1199841 ZFAND2A -0.55 -12.08 -0.43 2.01e-30 Longevity;Endometriosis; BRCA cis rs3784262 0.669 rs4646564 chr15:58351797 G/A cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.57 -0.39 3.66e-24 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs10181042 0.528 rs2564118 chr2:61233289 A/G cg15711740 chr2:61764176 XPO1 -0.34 -8.08 -0.3 3.35e-15 Crohn's disease; BRCA cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.91e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg05347473 chr6:146136440 FBXO30 0.39 7.93 0.3 9.72e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs7786808 0.653 rs4909213 chr7:158202404 G/A cg02030672 chr11:45687055 CHST1 0.52 11.53 0.41 4.55e-28 Obesity-related traits; BRCA cis rs11190604 0.767 rs10883485 chr10:102174805 G/C cg07080220 chr10:102295463 HIF1AN 0.5 10.14 0.37 1.66e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg20476274 chr7:133979776 SLC35B4 0.6 14.85 0.51 4.41e-43 Mean platelet volume; BRCA cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06481639 chr22:41940642 POLR3H -0.53 -8.77 -0.33 1.64e-17 Vitiligo; BRCA cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.35 7.84 0.3 1.83e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3784262 0.771 rs4775005 chr15:58208165 C/T cg12031962 chr15:58353849 ALDH1A2 0.42 11.0 0.4 6.62e-26 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9467773 1.000 rs28558133 chr6:26531433 G/C cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.71e-61 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg12310025 chr6:25882481 NA -0.49 -10.82 -0.39 3.66e-25 Intelligence (multi-trait analysis); BRCA trans rs3780486 0.846 rs12554995 chr9:33132044 A/G cg20290983 chr6:43655470 MRPS18A 1.1 41.39 0.85 5.5e-183 IgG glycosylation; BRCA cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg10523679 chr1:76189770 ACADM 0.88 20.8 0.64 8.8e-74 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.37 0.38 2.23e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg04450456 chr4:17643702 FAM184B 0.37 10.78 0.39 5.07e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs858239 0.601 rs3735228 chr7:23170427 T/G cg23682824 chr7:23144976 KLHL7 0.44 11.56 0.42 3.27e-28 Cerebrospinal fluid biomarker levels; BRCA cis rs16958440 0.867 rs75934126 chr18:44679781 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.78 18.69 0.59 1.7e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg22875332 chr1:76189707 ACADM 0.68 14.82 0.51 6.53e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg05535760 chr7:792225 HEATR2 0.72 13.08 0.46 8.63e-35 Cerebrospinal P-tau181p levels; BRCA trans rs2204008 0.806 rs11520229 chr12:38246448 C/A cg06521331 chr12:34319734 NA -0.53 -9.51 -0.35 3.7e-20 Bladder cancer; BRCA cis rs877529 0.967 rs139411 chr22:39552888 A/G cg12193277 chr22:39547181 CBX7 0.47 12.81 0.45 1.27e-33 Multiple myeloma; BRCA trans rs3780486 0.874 rs10813955 chr9:33141791 C/T cg20290983 chr6:43655470 MRPS18A 1.11 40.54 0.85 8.31e-179 IgG glycosylation; BRCA cis rs9487051 0.660 rs2884036 chr6:109642916 A/G cg21918786 chr6:109611834 NA 0.34 8.32 0.31 5.35e-16 Reticulocyte fraction of red cells; BRCA cis rs17767294 0.708 rs72848791 chr6:27986199 C/T cg08851530 chr6:28072375 NA 1.06 9.75 0.36 5.08e-21 Parkinson's disease; BRCA trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.6 0.55 9.92e-52 Morning vs. evening chronotype; BRCA cis rs965469 1.000 rs6037526 chr20:3251248 T/C cg25506879 chr20:3388711 C20orf194 -0.56 -10.92 -0.4 1.46e-25 IFN-related cytopenia; BRCA cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg02297831 chr4:17616191 MED28 0.36 8.42 0.32 2.43e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg16339924 chr4:17578868 LAP3 0.63 15.68 0.53 4.2e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg05623727 chr3:50126028 RBM5 -0.52 -12.31 -0.44 2.14e-31 Body mass index; BRCA cis rs6435161 0.959 rs1544913 chr2:203484781 T/C cg18429434 chr2:203499731 FAM117B -0.43 -9.0 -0.34 2.46e-18 Total cholesterol levels; BRCA cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg01028140 chr2:1542097 TPO -0.61 -12.23 -0.44 4.72e-31 IgG glycosylation; BRCA trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg08313168 chr12:7315531 NA 0.5 8.04 0.3 4.5e-15 Lung disease severity in cystic fibrosis; BRCA cis rs7829975 0.606 rs7819827 chr8:8797055 G/C cg06636001 chr8:8085503 FLJ10661 -0.54 -11.72 -0.42 7.42e-29 Mood instability; BRCA cis rs8062405 1.000 rs8055138 chr16:28891465 C/T cg09754948 chr16:28834200 ATXN2L 0.46 8.97 0.33 3.27e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9527 0.830 rs11191440 chr10:104641511 G/A cg04362960 chr10:104952993 NT5C2 0.48 10.54 0.38 4.79e-24 Arsenic metabolism; BRCA cis rs11098499 0.738 rs28408407 chr4:120376030 C/G cg09307838 chr4:120376055 NA 0.76 17.16 0.56 1.42e-54 Corneal astigmatism; BRCA cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg13770153 chr20:60521292 NA -0.45 -10.67 -0.39 1.4e-24 Body mass index; BRCA cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg20607798 chr8:58055168 NA 0.45 7.88 0.3 1.38e-14 Developmental language disorder (linguistic errors); BRCA cis rs9399135 0.967 rs9389261 chr6:135371148 C/G cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.46e-31 Red blood cell count; BRCA cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.55 12.07 0.43 2.3e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6700896 0.931 rs1938492 chr1:66117829 A/C cg04111102 chr1:66153794 NA 0.34 8.42 0.32 2.57e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs12517041 1.000 rs12520032 chr5:23285074 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA cis rs4948102 0.731 rs4543497 chr7:56047215 T/C cg09872392 chr7:56161020 PHKG1 -0.4 -9.15 -0.34 7.4e-19 Plasma homocysteine levels (post-methionine load test); BRCA cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.61 -0.45 1.06e-32 Chronic sinus infection; BRCA cis rs1801251 0.778 rs2675957 chr2:233754364 C/T cg25237894 chr2:233734115 C2orf82 -0.43 -13.33 -0.47 6.08e-36 Coronary artery disease; BRCA cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.69 -0.39 1.15e-24 Menarche (age at onset); BRCA cis rs919433 0.680 rs12621129 chr2:198265350 T/C cg00792783 chr2:198669748 PLCL1 -0.38 -8.15 -0.31 1.93e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs1997103 1.000 rs6593233 chr7:55406200 C/T cg20935933 chr6:143382018 AIG1 -0.6 -11.61 -0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg23583168 chr7:148888333 NA -0.79 -18.05 -0.58 3.66e-59 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg04981885 chr1:160991156 F11R -0.63 -11.62 -0.42 1.94e-28 Granulocyte percentage of myeloid white cells; BRCA cis rs7582180 0.613 rs12988464 chr2:100946285 A/G cg14675211 chr2:100938903 LONRF2 0.43 9.53 0.35 3.14e-20 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg26597838 chr10:835615 NA 0.6 10.39 0.38 1.87e-23 Eosinophil percentage of granulocytes; BRCA cis rs4780401 0.609 rs9923954 chr16:11816855 G/T cg01061890 chr16:11836724 TXNDC11 -0.56 -13.21 -0.46 2.03e-35 Rheumatoid arthritis; BRCA cis rs9463078 0.739 rs1041333 chr6:44945206 A/T cg25276700 chr6:44698697 NA -0.35 -8.18 -0.31 1.58e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs765787 0.530 rs12323957 chr15:45490773 C/T cg25801113 chr15:45476975 SHF -0.34 -8.26 -0.31 8.22e-16 Uric acid levels; BRCA trans rs7829975 0.593 rs2979241 chr8:8303353 G/C cg16141378 chr3:129829833 LOC729375 -0.39 -9.57 -0.35 2.27e-20 Mood instability; BRCA cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg10802521 chr3:52805072 NEK4 -0.33 -9.13 -0.34 8.81e-19 Bipolar disorder; BRCA cis rs1167827 0.710 rs1167836 chr7:75168900 T/A cg16384552 chr7:74938386 SPDYE8P -0.47 -9.78 -0.36 3.97e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -9.9 -0.36 1.36e-21 Mean corpuscular volume; BRCA cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg01283332 chr5:1856932 NA -0.34 -8.44 -0.32 2.17e-16 Cardiovascular disease risk factors; BRCA cis rs2795502 1.000 rs2142991 chr10:43341105 C/T cg20628663 chr10:43360327 NA -0.71 -13.64 -0.47 2.25e-37 Blood protein levels; BRCA cis rs57024841 0.562 rs7862602 chr9:139840471 G/T cg00693599 chr9:139836323 FBXW5 0.45 10.96 0.4 9.85e-26 Beta-trace protein levels; BRCA cis rs4631830 0.720 rs12412140 chr10:51503977 T/C cg20129853 chr10:51489980 NA 0.31 8.44 0.32 2.18e-16 Prostate-specific antigen levels; BRCA cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg06212747 chr3:49208901 KLHDC8B 0.49 10.02 0.37 4.9e-22 Parkinson's disease; BRCA cis rs2652834 0.861 rs4774472 chr15:63353760 C/A cg05507819 chr15:63340323 TPM1 0.57 10.29 0.38 4.29e-23 HDL cholesterol; BRCA cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg09184832 chr6:79620586 NA -0.49 -11.02 -0.4 5.45e-26 Intelligence (multi-trait analysis); BRCA cis rs9473147 0.516 rs9357546 chr6:47549495 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.92e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg00012203 chr2:219082015 ARPC2 0.52 10.49 0.38 7.6e-24 Colorectal cancer; BRCA cis rs2251381 0.565 rs2832279 chr21:30613466 G/T cg08807101 chr21:30365312 RNF160 0.38 7.97 0.3 7.24e-15 Selective IgA deficiency; BRCA cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -11.33 -0.41 3.04e-27 Electroencephalogram traits; BRCA cis rs7707921 0.690 rs6870335 chr5:81590070 A/T cg15871215 chr5:81402204 ATG10 -0.35 -8.32 -0.31 5.42e-16 Breast cancer; BRCA cis rs4268898 0.662 rs17733015 chr2:24509370 A/G cg08917208 chr2:24149416 ATAD2B 0.48 7.83 0.3 2.08e-14 Asthma; BRCA trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.52 -0.32 1.16e-16 Extrinsic epigenetic age acceleration; BRCA cis rs17539620 0.624 rs7770107 chr6:154836862 A/G cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21659725 chr3:3221576 CRBN 0.51 12.05 0.43 2.86e-30 Resting heart rate; BRCA cis rs2806561 0.894 rs629107 chr1:23537971 C/T cg12483005 chr1:23474871 LUZP1 0.37 8.12 0.31 2.36e-15 Height; BRCA cis rs10493773 0.609 rs11161660 chr1:86184066 C/T cg17807903 chr1:86174739 ZNHIT6 -0.53 -13.38 -0.47 3.49e-36 Urate levels in overweight individuals; BRCA cis rs61931739 0.500 rs11519123 chr12:34436478 A/G cg06521331 chr12:34319734 NA -0.52 -10.21 -0.37 9.32e-23 Morning vs. evening chronotype; BRCA cis rs17092148 0.887 rs2889849 chr20:33164277 A/G cg16810054 chr20:33298113 TP53INP2 -0.47 -10.63 -0.39 2e-24 Neuroticism; BRCA cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.42e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg18876405 chr7:65276391 NA 0.47 9.67 0.36 9.81e-21 Calcium levels; BRCA cis rs9463078 0.683 rs227855 chr6:44702352 T/C cg25276700 chr6:44698697 NA 0.35 7.85 0.3 1.71e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg26384229 chr12:38710491 ALG10B 0.58 13.17 0.46 3.41e-35 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg01305625 chr5:131593812 PDLIM4 0.34 8.07 0.3 3.4e-15 Acylcarnitine levels; BRCA cis rs17092148 0.616 rs6059908 chr20:33132159 T/C cg16810054 chr20:33298113 TP53INP2 -0.44 -9.47 -0.35 5.21e-20 Neuroticism; BRCA cis rs11785693 0.862 rs73189843 chr8:5000915 C/T cg26367366 chr8:4980734 NA 0.65 11.11 0.4 2.47e-26 Neuroticism (multi-trait analysis);Neuroticism; BRCA trans rs1997103 1.000 rs10252413 chr7:55396740 C/G cg20935933 chr6:143382018 AIG1 0.6 11.29 0.41 4.64e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs12760731 0.565 rs11585355 chr1:178181219 T/G cg00404053 chr1:178313656 RASAL2 0.65 7.82 0.3 2.27e-14 Obesity-related traits; BRCA cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.71 -16.05 -0.54 6.14e-49 Axial length; BRCA cis rs895636 0.749 rs748947 chr2:45192600 A/C cg16198908 chr2:45192207 NA 0.49 9.26 0.34 3.05e-19 Metabolite levels;Fasting plasma glucose; BRCA cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg24549020 chr5:56110836 MAP3K1 -0.58 -10.63 -0.39 1.99e-24 Initial pursuit acceleration; BRCA cis rs4478858 0.684 rs3766289 chr1:31760128 G/A cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs12586317 0.620 rs12588810 chr14:35554484 C/T cg16230307 chr14:35515116 FAM177A1 0.74 15.02 0.51 7.09e-44 Psoriasis; BRCA cis rs2625529 0.641 rs2035379 chr15:72293202 C/T cg16672083 chr15:72433130 SENP8 -0.85 -17.5 -0.57 2.71e-56 Red blood cell count; BRCA cis rs73072330 1.000 rs17729010 chr3:47912703 A/G cg09665691 chr3:47563885 NA -0.98 -9.04 -0.34 1.92e-18 Stem cell growth factor beta levels; BRCA trans rs4650994 0.544 rs2476561 chr1:178619900 C/T cg05059571 chr16:84539110 KIAA1609 -0.52 -11.67 -0.42 1.16e-28 HDL cholesterol levels;HDL cholesterol; BRCA cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.31 0.35 1.94e-19 Tonsillectomy; BRCA cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.2e-36 Developmental language disorder (linguistic errors); BRCA cis rs459571 0.920 rs460154 chr9:136909309 C/T cg13789015 chr9:136890014 NCRNA00094 0.57 12.09 0.43 1.93e-30 Platelet distribution width; BRCA cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg13319975 chr6:146136371 FBXO30 -0.35 -8.11 -0.31 2.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7639513 0.767 rs3806661 chr3:12705855 A/G cg23032965 chr3:12705835 RAF1 0.71 15.61 0.53 9.16e-47 Itch intensity from mosquito bite; BRCA cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg23583168 chr7:148888333 NA -0.8 -19.27 -0.61 1.44e-65 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg05340658 chr4:99064831 C4orf37 0.62 14.89 0.51 2.77e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg26647111 chr11:31128758 NA -0.45 -9.92 -0.37 1.15e-21 Red blood cell count; BRCA cis rs1577917 0.876 rs12201992 chr6:86618219 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA cis rs4481887 0.893 rs10888355 chr1:248457180 G/A cg00666640 chr1:248458726 OR2T12 0.33 8.66 0.32 3.96e-17 Common traits (Other); BRCA cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg11822812 chr5:140052017 DND1 0.29 8.12 0.31 2.38e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9467773 0.620 rs2101582 chr6:26622734 C/T cg09904177 chr6:26538194 HMGN4 0.48 15.45 0.52 5.34e-46 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.845 rs10165767 chr2:227781863 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.12 -0.34 9.3e-19 Pulmonary function; BRCA cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -10.43 -0.38 1.28e-23 Schizophrenia; BRCA cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg23583168 chr7:148888333 NA -0.75 -16.77 -0.55 1.34e-52 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg22903471 chr2:27725779 GCKR -0.38 -9.18 -0.34 5.87e-19 Total body bone mineral density; BRCA cis rs10484885 0.824 rs72919982 chr6:90532600 C/G cg13799429 chr6:90582589 CASP8AP2 -0.76 -9.64 -0.36 1.23e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.72 -0.45 3.32e-33 Bipolar disorder; BRCA cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs3099143 1.000 rs3099138 chr15:77115524 G/A cg21673338 chr15:77095150 SCAPER -0.54 -9.27 -0.34 2.82e-19 Recalcitrant atopic dermatitis; BRCA cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.73 0.33 2.16e-17 Glomerular filtration rate (creatinine); BRCA cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg12573674 chr2:1569213 NA -0.59 -13.05 -0.46 1.14e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6963495 0.556 rs818474 chr7:105155243 A/T cg19920283 chr7:105172520 RINT1 0.44 9.02 0.34 2.21e-18 Bipolar disorder (body mass index interaction); BRCA cis rs6964587 0.967 rs10231350 chr7:91808499 G/T cg17063962 chr7:91808500 NA 0.63 14.87 0.51 3.75e-43 Breast cancer; BRCA cis rs6750795 0.870 rs6754952 chr2:232381245 G/T cg19187155 chr2:232395269 NMUR1 -0.8 -21.22 -0.64 4.98e-76 Height; BRCA trans rs6582630 0.519 rs8189461 chr12:38374870 G/T cg06521331 chr12:34319734 NA -0.46 -8.49 -0.32 1.46e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs2742234 0.955 rs1272142 chr10:43695484 G/T cg02780029 chr10:43622663 RET -0.36 -8.88 -0.33 6.52e-18 Hirschsprung disease; BRCA cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.47 0.35 5.28e-20 Menopause (age at onset); BRCA cis rs9467773 1.000 rs9467778 chr6:26534743 T/C cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs1371614 0.513 rs562311 chr2:27098086 G/A cg12368169 chr2:27073192 DPYSL5 -0.3 -8.76 -0.33 1.78e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.61 -0.45 1.06e-32 Personality dimensions; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg18402987 chr7:1209562 NA 0.6 11.81 0.42 3.07e-29 Longevity;Endometriosis; BRCA cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg13256891 chr4:100009986 ADH5 0.46 9.68 0.36 8.9e-21 Alcohol dependence; BRCA cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.69 11.67 0.42 1.16e-28 Mean platelet volume; BRCA cis rs9814567 1.000 rs9841212 chr3:134191938 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.35 -8.1 -0.31 2.78e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9814567 0.896 rs4435682 chr3:134344182 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 17.85 0.58 3.83e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10733682 0.659 rs867560 chr9:129465233 C/G cg00232160 chr9:129468157 NA -0.35 -8.37 -0.31 3.75e-16 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg25036284 chr2:26402008 FAM59B -0.83 -13.06 -0.46 1.05e-34 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs13095912 0.785 rs6444076 chr3:185321405 T/C cg11274856 chr3:185301563 NA 0.55 13.28 0.47 1.01e-35 Systolic blood pressure; BRCA cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg12564285 chr5:131593104 PDLIM4 0.35 9.39 0.35 1.06e-19 Breast cancer; BRCA cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg24596788 chr1:163392923 NA -0.36 -9.54 -0.35 2.91e-20 Motion sickness; BRCA cis rs9810890 0.850 rs73198858 chr3:128514061 T/G cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs7590368 1.000 rs13429247 chr2:10960529 A/G cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.02e-15 Educational attainment (years of education); BRCA cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6840258 0.660 rs74784659 chr4:87888929 G/A cg08197287 chr4:87952173 AFF1 -0.46 -8.4 -0.32 2.8e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA trans rs877282 0.891 rs12767062 chr10:797961 C/T cg22713356 chr15:30763199 NA 1.41 28.9 0.75 4.24e-118 Uric acid levels; BRCA cis rs765787 0.530 rs1706831 chr15:45516230 T/C cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg06212747 chr3:49208901 KLHDC8B 0.68 15.13 0.51 2.1e-44 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA trans rs1493916 1.000 rs7238717 chr18:31395186 C/T cg15819921 chr19:927150 ARID3A -0.48 -9.17 -0.34 6.67e-19 Life satisfaction; BRCA cis rs8028182 0.666 rs4886708 chr15:75762608 C/T cg20655648 chr15:75932815 IMP3 0.41 8.01 0.3 5.53e-15 Sudden cardiac arrest; BRCA cis rs61931739 0.500 rs7307583 chr12:34521711 T/C cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.3e-22 Morning vs. evening chronotype; BRCA trans rs7824557 0.736 rs35392635 chr8:11164349 G/C cg08975724 chr8:8085496 FLJ10661 0.43 8.08 0.3 3.28e-15 Retinal vascular caliber; BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.7 0.36 7.35e-21 Gut microbiome composition (summer); BRCA cis rs796364 0.625 rs1369843 chr2:201088171 A/G cg23649088 chr2:200775458 C2orf69 0.55 9.55 0.35 2.79e-20 Schizophrenia; BRCA cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg08885076 chr2:99613938 TSGA10 -0.59 -13.24 -0.46 1.49e-35 Chronic sinus infection; BRCA cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg04317338 chr11:64019027 PLCB3 0.58 9.81 0.36 2.87e-21 Mean platelet volume; BRCA cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg12365402 chr11:9010492 NRIP3 -0.37 -8.55 -0.32 9.42e-17 Hemoglobin concentration; BRCA cis rs365132 0.875 rs2962844 chr5:176333748 G/T cg16309518 chr5:176445507 NA -0.4 -9.75 -0.36 5e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2070488 1.000 rs4147024 chr3:38456664 C/T cg24069376 chr3:38537580 EXOG 0.4 11.54 0.42 4.09e-28 Electrocardiographic conduction measures; BRCA cis rs7762018 1.000 rs11961560 chr6:170130121 T/C cg19338460 chr6:170058176 WDR27 -0.45 -8.03 -0.3 4.53e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg06115741 chr20:33292138 TP53INP2 0.5 11.22 0.41 8.59e-27 Coronary artery disease; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg23978390 chr7:1156363 C7orf50 0.33 8.16 0.31 1.81e-15 Longevity;Endometriosis; BRCA cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.36 -12.28 -0.44 2.86e-31 Bipolar disorder; BRCA cis rs6842047 0.809 rs3087505 chr4:187179486 A/G cg23442198 chr4:187126114 CYP4V2 0.85 9.8 0.36 3.1e-21 Blood protein levels; BRCA cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -10.04 -0.37 4.14e-22 Mean corpuscular volume; BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg01262667 chr19:19385393 TM6SF2 0.43 11.03 0.4 5.36e-26 Tonsillectomy; BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.75 16.83 0.55 7.34e-53 Lymphocyte counts; BRCA cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg07395648 chr5:131743802 NA 0.37 7.99 0.3 6.21e-15 Breast cancer; BRCA trans rs7647973 0.626 rs62260723 chr3:49872124 T/C cg21659725 chr3:3221576 CRBN 0.47 8.66 0.32 3.71e-17 Menarche (age at onset); BRCA cis rs6460942 0.731 rs75994414 chr7:12307992 C/A cg06484146 chr7:12443880 VWDE -0.64 -8.81 -0.33 1.14e-17 Coronary artery disease; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs1712517 0.873 rs7894240 chr10:105000369 T/C cg05636881 chr10:105038444 INA -0.35 -8.17 -0.31 1.68e-15 Migraine; BRCA cis rs11690935 0.851 rs6433319 chr2:172830953 C/T cg13550731 chr2:172543902 DYNC1I2 -0.76 -22.54 -0.67 3.05e-83 Schizophrenia; BRCA cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg23750338 chr8:142222470 SLC45A4 -0.5 -12.17 -0.43 8.25e-31 Immature fraction of reticulocytes; BRCA cis rs7267979 1.000 rs2856 chr20:25433536 T/C cg08601574 chr20:25228251 PYGB 0.33 7.82 0.3 2.23e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg00071950 chr4:10020882 SLC2A9 -0.47 -11.19 -0.4 1.16e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg22535103 chr8:58192502 C8orf71 -0.44 -8.85 -0.33 8.5e-18 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.41e-20 Menopause (age at onset); BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg03354898 chr7:1950403 MAD1L1 -0.48 -9.68 -0.36 9.37e-21 Bipolar disorder and schizophrenia; BRCA cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg23711669 chr6:146136114 FBXO30 0.71 14.67 0.5 3.38e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs12618769 0.597 rs72819981 chr2:99040696 T/C cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs3917254 0.596 rs12618571 chr2:102767192 G/A cg22835712 chr2:102737379 NA -0.54 -8.78 -0.33 1.51e-17 Blood protein levels; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg16606324 chr3:10149918 C3orf24 -0.57 -10.15 -0.37 1.54e-22 Alzheimer's disease; BRCA cis rs2066819 1.000 rs77131854 chr12:56664231 C/T cg26734620 chr12:56694298 CS 0.92 10.64 0.39 1.83e-24 Psoriasis vulgaris; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg09704166 chr2:114031854 PAX8;LOC440839 -0.38 -7.88 -0.3 1.4e-14 Lymphocyte counts; BRCA cis rs8017423 0.791 rs7146250 chr14:90711703 A/G cg04374321 chr14:90722782 PSMC1 0.74 20.13 0.62 3.8e-70 Mortality in heart failure; BRCA cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg26395211 chr5:140044315 WDR55 0.37 8.61 0.32 5.85e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg00531865 chr16:30841666 NA -0.38 -9.02 -0.34 2.25e-18 Dementia with Lewy bodies; BRCA trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg25206134 chr2:45395956 NA 0.51 8.66 0.32 3.71e-17 Bipolar disorder; BRCA cis rs870825 0.616 rs14969 chr4:185615764 C/A cg04058563 chr4:185651563 MLF1IP 0.78 17.17 0.56 1.32e-54 Blood protein levels; BRCA cis rs9309473 1.000 rs13398956 chr2:73720258 C/A cg20560298 chr2:73613845 ALMS1 -0.44 -10.67 -0.39 1.46e-24 Metabolite levels; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg10729496 chr3:10149963 C3orf24 0.45 8.74 0.33 2.11e-17 Alzheimer's disease; BRCA cis rs9487051 0.676 rs9386775 chr6:109561779 T/C cg21918786 chr6:109611834 NA -0.32 -8.25 -0.31 9.15e-16 Reticulocyte fraction of red cells; BRCA cis rs7847628 0.587 rs12684934 chr9:123593159 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.84 20.47 0.63 5.21e-72 Birth weight; BRCA cis rs12711979 1.000 rs12711979 chr2:3869559 A/G cg17052675 chr2:3827356 NA -0.44 -11.91 -0.43 1.1e-29 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs12950390 0.853 rs28589850 chr17:45855713 A/G cg03474202 chr17:45855739 NA -0.47 -12.85 -0.45 9.12e-34 IgG glycosylation; BRCA cis rs7264396 0.513 rs2425092 chr20:34306815 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Total cholesterol levels; BRCA cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg04944784 chr2:26401820 FAM59B 1.0 16.48 0.55 4.02e-51 Gut microbiome composition (summer); BRCA cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg19318889 chr4:1322082 MAEA -0.45 -9.64 -0.36 1.28e-20 Obesity-related traits; BRCA cis rs4845875 0.535 rs4846045 chr1:11840380 A/G cg24844545 chr1:11908347 NPPA 0.33 8.22 0.31 1.17e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs477692 0.673 rs579952 chr10:131356084 A/T cg24747557 chr10:131355152 MGMT 0.37 9.19 0.34 5.34e-19 Response to temozolomide; BRCA cis rs16944613 0.541 rs13313427 chr15:91090768 G/A cg26821196 chr15:91095069 CRTC3 0.47 8.52 0.32 1.18e-16 Colorectal cancer; BRCA cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg20891283 chr12:69753455 YEATS4 0.84 28.41 0.75 1.93e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg00012203 chr2:219082015 ARPC2 0.64 14.22 0.49 4.53e-40 Colorectal cancer; BRCA cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg04455712 chr21:45112962 RRP1B 0.38 9.74 0.36 5.49e-21 Mean corpuscular volume; BRCA cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg16339924 chr4:17578868 LAP3 0.63 15.41 0.52 8.34e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs826838 0.935 rs980571 chr12:39127532 C/G cg26384229 chr12:38710491 ALG10B -0.62 -16.24 -0.54 6.8e-50 Heart rate; BRCA cis rs12681288 0.523 rs111782857 chr8:962486 T/C cg04851639 chr8:1020857 NA -0.32 -8.82 -0.33 1.05e-17 Schizophrenia; BRCA cis rs6893300 0.542 rs7736300 chr5:179196898 G/A cg14593053 chr5:179126677 CANX 0.48 12.95 0.46 3.14e-34 Resting heart rate; BRCA cis rs3099143 1.000 rs3102712 chr15:77058926 G/A cg21673338 chr15:77095150 SCAPER -0.53 -9.55 -0.35 2.71e-20 Recalcitrant atopic dermatitis; BRCA cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg21770322 chr7:97807741 LMTK2 0.45 11.26 0.41 5.83e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg13010199 chr12:38710504 ALG10B -0.37 -8.55 -0.32 9.27e-17 Morning vs. evening chronotype; BRCA cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg14844989 chr11:31128820 NA -0.44 -9.27 -0.34 2.83e-19 Red blood cell count; BRCA cis rs698833 0.852 rs2582918 chr2:44582275 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.6 12.37 0.44 1.11e-31 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg00012203 chr2:219082015 ARPC2 -0.47 -9.1 -0.34 1.15e-18 Ulcerative colitis; BRCA cis rs10992471 0.603 rs7033979 chr9:95223980 A/G cg14631576 chr9:95140430 CENPP -0.39 -9.47 -0.35 5.52e-20 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg09263875 chr16:632152 PIGQ 0.72 21.51 0.65 1.22e-77 Height; BRCA cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg10802521 chr3:52805072 NEK4 -0.32 -8.27 -0.31 8e-16 Bipolar disorder; BRCA cis rs8028313 0.630 rs16951105 chr15:67965694 A/G cg05925327 chr15:68127851 NA -0.37 -7.82 -0.3 2.13e-14 Obesity; BRCA cis rs9296092 0.521 rs56332659 chr6:33537887 T/C cg13560919 chr6:33536144 NA -0.87 -16.85 -0.55 5.31e-53 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg23285459 chr7:2802560 GNA12 -0.37 -9.39 -0.35 1.01e-19 Height; BRCA cis rs13040088 1.000 rs2295000 chr20:61536938 A/G cg23096297 chr20:61557774 DIDO1 -0.9 -17.81 -0.58 6.73e-58 Menopause (age at onset); BRCA cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.81 0.3 2.32e-14 Melanoma; BRCA cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.47 0.66 7.52e-83 Chronic sinus infection; BRCA cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg25730555 chr22:47059586 GRAMD4 -0.47 -8.99 -0.33 2.83e-18 Urate levels in obese individuals; BRCA cis rs7267979 0.727 rs2474765 chr20:25245950 G/T cg08601574 chr20:25228251 PYGB 0.34 8.16 0.31 1.77e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11148252 0.819 rs7336679 chr13:53043333 G/A cg00495681 chr13:53174319 NA 0.43 9.03 0.34 2.03e-18 Lewy body disease; BRCA cis rs1401999 1.000 rs10937158 chr3:183708439 T/C cg20387954 chr3:183756860 HTR3D 0.46 10.31 0.38 3.71e-23 Anterior chamber depth; BRCA cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg03477792 chr4:77819574 ANKRD56 0.66 15.67 0.53 4.35e-47 Emphysema distribution in smoking; BRCA cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg18105134 chr13:113819100 PROZ -0.59 -13.75 -0.48 6.96e-38 Platelet distribution width; BRCA cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg05985134 chr18:33552581 C18orf21 0.65 11.65 0.42 1.42e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs3806843 0.868 rs2531345 chr5:140126781 T/G cg11822812 chr5:140052017 DND1 -0.32 -8.81 -0.33 1.15e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg04450456 chr4:17643702 FAM184B -0.34 -9.89 -0.36 1.44e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs911555 0.755 rs8010247 chr14:103933556 A/G cg17675199 chr6:35436792 RPL10A -0.3 -8.21 -0.31 1.2e-15 Intelligence (multi-trait analysis); BRCA cis rs8072100 0.967 rs8074149 chr17:45583375 A/C cg25173405 chr17:45401733 C17orf57 0.44 9.11 0.34 1.01e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.87 0.3 1.54e-14 Axial length; BRCA cis rs7267979 1.000 rs4815408 chr20:25346678 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 21.88 0.65 1.24e-79 Platelet count; BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18301423 chr5:131593218 PDLIM4 -0.33 -8.16 -0.31 1.82e-15 Acylcarnitine levels; BRCA cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg26384229 chr12:38710491 ALG10B 0.71 16.45 0.55 5.52e-51 Bladder cancer; BRCA cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg12386194 chr3:101231763 SENP7 0.45 9.56 0.35 2.58e-20 Colorectal cancer; BRCA cis rs2070488 0.965 rs13097628 chr3:38521156 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.25 0.63 8.21e-71 Electrocardiographic conduction measures; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg26608667 chr7:1196370 ZFAND2A 0.46 10.46 0.38 9.92e-24 Longevity;Endometriosis; BRCA cis rs514406 0.929 rs557715 chr1:53321593 C/G cg16325326 chr1:53192061 ZYG11B 0.7 17.51 0.57 2.2e-56 Monocyte count; BRCA cis rs11105298 0.891 rs10858894 chr12:89914261 T/C cg00757033 chr12:89920650 WDR51B 0.54 11.08 0.4 3.24e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9427116 0.531 rs35504625 chr1:154599778 C/G cg17218026 chr1:154582156 ADAR 0.28 8.16 0.31 1.81e-15 Blood protein levels; BRCA cis rs1468333 0.691 rs35839251 chr5:137584080 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.4 8.44 0.32 2.06e-16 Resting heart rate; BRCA cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg16230307 chr14:35515116 FAM177A1 0.77 15.6 0.53 9.97e-47 Psoriasis; BRCA cis rs7587476 0.784 rs36086595 chr2:215680293 A/G cg04004882 chr2:215674386 BARD1 0.65 12.22 0.44 5.09e-31 Neuroblastoma; BRCA cis rs910316 0.967 rs4899550 chr14:75647666 C/T cg08847533 chr14:75593920 NEK9 -0.83 -20.34 -0.63 2.66e-71 Height; BRCA cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg03433033 chr1:76189801 ACADM 0.68 13.64 0.47 2.19e-37 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 1.97e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs10129255 0.518 rs8004895 chr14:107193377 T/C cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.69e-17 Kawasaki disease; BRCA cis rs4803468 1.000 rs11670757 chr19:41913431 G/T cg09537434 chr19:41945824 ATP5SL -1.0 -25.35 -0.71 1.18e-98 Height; BRCA cis rs7264396 0.635 rs6121073 chr20:34457513 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.61 -0.5 6.48e-42 Total cholesterol levels; BRCA cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11890956 chr21:40555474 PSMG1 1.06 30.49 0.77 1.02e-126 Cognitive function; BRCA cis rs7945718 0.905 rs7124484 chr11:12745271 G/A cg25843174 chr11:12811716 TEAD1 0.23 8.69 0.33 2.97e-17 Educational attainment (years of education); BRCA cis rs7631605 0.905 rs6808735 chr3:37104246 A/C cg15934958 chr3:37212084 LRRFIP2 0.47 10.83 0.39 3.16e-25 Cerebrospinal P-tau181p levels; BRCA cis rs34779708 0.931 rs67976880 chr10:35372261 G/C cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs698833 0.886 rs698775 chr2:44588941 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.61 12.68 0.45 5.1e-33 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.38e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs61990749 0.597 rs2267761 chr14:78147849 G/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.63 -9.68 -0.36 9.08e-21 Fibroblast growth factor basic levels; BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg08888203 chr3:10149979 C3orf24 0.63 11.82 0.42 2.73e-29 Alzheimer's disease; BRCA cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg06484146 chr7:12443880 VWDE -0.74 -10.77 -0.39 5.91e-25 Coronary artery disease; BRCA cis rs7192750 0.617 rs9929256 chr16:72040032 A/C cg14768367 chr16:72042858 DHODH 0.59 9.52 0.35 3.6e-20 LDL cholesterol levels;Total cholesterol levels; BRCA cis rs10267417 0.603 rs4721829 chr7:19873199 A/G cg05791153 chr7:19748676 TWISTNB 0.48 9.14 0.34 8.22e-19 Night sleep phenotypes; BRCA cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11890956 chr21:40555474 PSMG1 -1.04 -29.63 -0.76 4.49e-122 Cognitive function; BRCA cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg21605333 chr4:119757512 SEC24D 1.14 12.65 0.45 6.54e-33 Cannabis dependence symptom count; BRCA cis rs701145 0.585 rs6440935 chr3:153816976 A/T cg12800244 chr3:153838788 SGEF 0.63 7.87 0.3 1.47e-14 Coronary artery disease; BRCA cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg26528668 chr16:1614120 IFT140 0.37 8.33 0.31 4.79e-16 Coronary artery disease; BRCA cis rs4588572 0.644 rs6882191 chr5:77743098 G/A cg11547950 chr5:77652471 NA -0.45 -8.58 -0.32 7.33e-17 Triglycerides; BRCA cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg25358565 chr5:93447407 FAM172A -1.18 -17.88 -0.58 2.9e-58 Diabetic retinopathy; BRCA cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs9443189 0.570 rs72888705 chr6:76403114 A/G cg01950844 chr6:76311363 SENP6 0.84 13.53 0.47 7.52e-37 Prostate cancer; BRCA trans rs9329221 0.527 rs34308302 chr8:10332022 C/T cg06636001 chr8:8085503 FLJ10661 -0.5 -10.05 -0.37 3.63e-22 Neuroticism; BRCA cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg08045932 chr20:61659980 NA 0.49 11.35 0.41 2.57e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg11764359 chr7:65958608 NA 0.79 19.31 0.61 8.49e-66 Aortic root size; BRCA trans rs6076960 0.652 rs3905171 chr20:6211177 T/C cg21095983 chr6:86352623 SYNCRIP 0.37 8.22 0.31 1.18e-15 Smooth-surface caries; BRCA cis rs1669338 0.588 rs3864049 chr3:3186719 T/G cg16797762 chr3:3221439 CRBN -0.69 -10.57 -0.39 3.55e-24 White matter integrity; BRCA cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg08917208 chr2:24149416 ATAD2B 0.93 13.82 0.48 3.34e-38 Lymphocyte counts; BRCA trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg26248373 chr2:1572462 NA -0.61 -13.78 -0.48 5.39e-38 IgG glycosylation; BRCA cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg12863693 chr15:85201151 NMB -0.55 -12.08 -0.43 2.07e-30 Schizophrenia; BRCA cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg02931644 chr1:25747376 RHCE 0.42 11.46 0.41 8.59e-28 Erythrocyte sedimentation rate; BRCA cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.07 -0.3 3.57e-15 Depression; BRCA cis rs7264396 0.690 rs2425164 chr20:34434916 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.11 0.31 2.51e-15 Total cholesterol levels; BRCA cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg13256891 chr4:100009986 ADH5 0.47 8.9 0.33 5.92e-18 Alcohol dependence; BRCA cis rs3784262 0.669 rs3204690 chr15:58246768 A/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.87 -0.36 1.73e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs12464559 0.522 rs1916301 chr2:152640498 G/A cg01189475 chr2:152685088 ARL5A 0.63 9.16 0.34 6.97e-19 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs3806843 0.838 rs2337514 chr5:140132732 T/C cg16179182 chr5:140090404 VTRNA1-1 0.4 9.14 0.34 8.25e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg11833968 chr6:79620685 NA 0.42 9.07 0.34 1.44e-18 Intelligence (multi-trait analysis); BRCA trans rs9325144 0.602 rs10785590 chr12:38694145 C/T cg23762105 chr12:34175262 ALG10 -0.4 -9.81 -0.36 2.96e-21 Morning vs. evening chronotype; BRCA cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg25019033 chr10:957182 NA -0.41 -7.85 -0.3 1.73e-14 Eosinophil percentage of granulocytes; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07092213 chr7:1199455 ZFAND2A -0.41 -7.96 -0.3 7.83e-15 Longevity;Endometriosis; BRCA cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.83 -0.3 2.04e-14 Aortic root size; BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg21747090 chr2:27597821 SNX17 -0.41 -8.82 -0.33 1.09e-17 Total body bone mineral density; BRCA cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.52 -0.5 1.79e-41 Chronic sinus infection; BRCA cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg18351406 chr4:77819688 ANKRD56 0.46 9.7 0.36 7.85e-21 Emphysema distribution in smoking; BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.41 0.35 8.99e-20 Alzheimer's disease; BRCA trans rs8073060 0.544 rs225244 chr17:33946581 A/G cg19694781 chr19:47549865 TMEM160 1.06 21.34 0.65 1.05e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg07092213 chr7:1199455 ZFAND2A -0.54 -11.78 -0.42 4.08e-29 Longevity;Endometriosis; BRCA cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg22906224 chr7:99728672 NA 0.44 8.23 0.31 1.06e-15 Coronary artery disease; BRCA cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg23711669 chr6:146136114 FBXO30 0.74 16.82 0.55 7.41e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs12135062 0.538 rs2651929 chr1:3101353 C/T cg00254258 chr1:3105189 PRDM16 0.36 8.78 0.33 1.49e-17 Migraine; BRCA cis rs12541635 0.966 rs2029881 chr8:107002226 A/G cg10147462 chr8:107024639 NA 0.37 9.91 0.37 1.2e-21 Age of smoking initiation; BRCA cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg10578991 chr7:12443926 VWDE -0.52 -7.94 -0.3 9.11e-15 Coronary artery disease; BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00149659 chr3:10157352 C3orf10 -0.72 -12.68 -0.45 4.89e-33 Alzheimer's disease; BRCA cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.13e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg04990556 chr1:26633338 UBXN11 -0.47 -9.23 -0.34 3.82e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg11764359 chr7:65958608 NA 0.6 13.57 0.47 4.95e-37 Aortic root size; BRCA trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.28 -0.34 2.55e-19 Intelligence (multi-trait analysis); BRCA trans rs7613875 0.620 rs7430334 chr3:50078221 T/C cg21659725 chr3:3221576 CRBN -0.35 -8.7 -0.33 2.74e-17 Body mass index; BRCA cis rs4595586 0.545 rs4768505 chr12:39380338 C/A cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.84e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11025559 0.812 rs10766678 chr11:20507180 A/G cg19653624 chr11:20408972 PRMT3 -0.45 -10.36 -0.38 2.36e-23 Pursuit maintenance gain; BRCA cis rs4984778 0.750 rs7198064 chr16:1272472 C/T cg07748719 chr16:1272498 TPSG1 0.5 11.14 0.4 1.76e-26 Blood protein levels; BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg21747090 chr2:27597821 SNX17 -0.4 -8.55 -0.32 9.09e-17 Total body bone mineral density; BRCA cis rs7267979 1.000 rs2500436 chr20:25406366 G/C cg08601574 chr20:25228251 PYGB -0.37 -8.81 -0.33 1.21e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg15112475 chr7:1198522 ZFAND2A -0.54 -12.19 -0.43 6.83e-31 Longevity;Endometriosis; BRCA cis rs10795061 0.576 rs12219804 chr10:3710626 C/T cg22632523 chr10:3711048 NA 0.43 10.93 0.4 1.25e-25 Subjective well-being; BRCA cis rs7903847 0.642 rs10882922 chr10:99158537 C/T cg20016023 chr10:99160130 RRP12 -0.26 -8.36 -0.31 3.83e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs3772130 0.962 rs6789736 chr3:121543084 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.95 0.4 1.08e-25 Cognitive performance; BRCA cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.76 0.39 6.41e-25 Cognitive ability; BRCA cis rs367943 0.730 rs2914174 chr5:112978531 C/T cg12552261 chr5:112820674 MCC -0.43 -8.93 -0.33 4.51e-18 Type 2 diabetes; BRCA cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg00277334 chr10:82204260 NA -0.85 -24.9 -0.7 3.41e-96 Post bronchodilator FEV1; BRCA cis rs10193935 1.000 rs13424523 chr2:42413562 T/G cg27598129 chr2:42591480 NA -0.94 -15.03 -0.51 6.18e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs559928 0.556 rs734762 chr11:63912189 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 11.13 0.4 2.02e-26 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.2 0.31 1.34e-15 Mean platelet volume; BRCA cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -8.99 -0.34 2.73e-18 Alzheimer's disease (late onset); BRCA cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.53 0.41 4.48e-28 Homoarginine levels; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg23285459 chr7:2802560 GNA12 -0.36 -9.17 -0.34 6.39e-19 Height; BRCA cis rs7089973 0.584 rs4752255 chr10:116576790 C/T cg03647239 chr10:116582469 FAM160B1 0.38 7.96 0.3 7.7e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs919433 0.963 rs7582736 chr2:198170342 A/G cg10820045 chr2:198174542 NA -0.39 -8.07 -0.3 3.47e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4713118 0.955 rs9468204 chr6:27688809 C/T cg20933634 chr6:27740509 NA 0.44 8.56 0.32 8.24e-17 Parkinson's disease; BRCA cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg00531865 chr16:30841666 NA 0.39 9.25 0.34 3.21e-19 Dementia with Lewy bodies; BRCA cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg12923728 chr3:195709715 SDHAP1 -0.6 -12.93 -0.46 3.83e-34 Pancreatic cancer; BRCA trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.71 0.55 2.71e-52 Morning vs. evening chronotype; BRCA cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg07507251 chr3:52567010 NT5DC2 0.39 9.29 0.34 2.47e-19 Electroencephalogram traits; BRCA cis rs6460942 1.000 rs73053527 chr7:12313008 C/A cg06484146 chr7:12443880 VWDE -0.62 -8.6 -0.32 5.97e-17 Coronary artery disease; BRCA trans rs2204008 0.744 rs11495519 chr12:38060546 C/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 7.99e-21 Bladder cancer; BRCA cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg12935359 chr14:103987150 CKB 0.64 14.71 0.5 2.11e-42 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.510 rs10458355 chr1:183063993 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 18.02 0.58 5.02e-59 Fuchs's corneal dystrophy; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.13 -0.4 1.96e-26 Lymphocyte counts; BRCA cis rs877529 0.967 rs139385 chr22:39530132 C/A cg12193277 chr22:39547181 CBX7 0.48 13.09 0.46 7.6e-35 Multiple myeloma; BRCA cis rs9633740 1.000 rs7900536 chr10:82253701 G/T cg01528321 chr10:82214614 TSPAN14 1.05 20.63 0.63 7.39e-73 Post bronchodilator FEV1; BRCA cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg06028605 chr16:24865363 SLC5A11 0.39 8.05 0.3 3.98e-15 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.54 -0.32 1e-16 Bipolar disorder; BRCA trans rs61931739 0.500 rs11053278 chr12:34555955 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.22 0.34 4.33e-19 Morning vs. evening chronotype; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -12.03 -0.43 3.51e-30 Alzheimer's disease; BRCA cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg14008862 chr17:28927542 LRRC37B2 -0.54 -8.01 -0.3 5.64e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.21e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.538 rs8189550 chr12:38333058 T/G cg26384229 chr12:38710491 ALG10B -0.42 -9.71 -0.36 7.22e-21 Drug-induced liver injury (flucloxacillin); BRCA trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.57 -0.39 3.71e-24 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.699 rs6449171 chr4:9965998 C/T cg26043149 chr18:55253948 FECH 0.37 8.16 0.31 1.83e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11644478 chr21:40555479 PSMG1 0.85 19.44 0.61 1.75e-66 Cognitive function; BRCA cis rs7903847 0.673 rs3818908 chr10:99132701 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.51 -0.32 1.27e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7903847 0.596 rs11189203 chr10:99159096 C/A cg20016023 chr10:99160130 RRP12 -0.26 -8.39 -0.31 3.16e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs10046574 0.519 rs10250947 chr7:135211017 T/G cg27474649 chr7:135195673 CNOT4 0.63 10.71 0.39 9.6e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7727544 0.735 rs272881 chr5:131669264 G/A cg24060327 chr5:131705240 SLC22A5 -0.49 -10.38 -0.38 1.93e-23 Blood metabolite levels; BRCA cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg18270830 chr10:32634957 EPC1 0.58 10.04 0.37 4.01e-22 Sexual dysfunction (female); BRCA trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.06 -0.56 4.9e-54 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.874 rs10167086 chr2:227792729 A/T cg11843606 chr2:227700838 RHBDD1 0.4 8.85 0.33 8.4e-18 Pulmonary function; BRCA cis rs34779708 0.966 rs113170867 chr10:35450147 C/T cg03585969 chr10:35415529 CREM 0.55 11.17 0.4 1.33e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4268898 0.722 rs10445893 chr2:24407128 A/G cg06627628 chr2:24431161 ITSN2 0.44 9.09 0.34 1.25e-18 Asthma; BRCA cis rs1941023 0.584 rs2241920 chr11:60164204 A/G cg08716584 chr11:60157161 MS4A7 0.41 9.82 0.36 2.7e-21 Congenital heart disease (maternal effect); BRCA cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.55 12.08 0.43 2.18e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6028335 0.610 rs16987687 chr20:37566737 T/C cg16355469 chr20:37678765 NA 0.44 7.94 0.3 9.2e-15 Alcohol and nicotine co-dependence; BRCA cis rs7917772 0.582 rs10786687 chr10:104336994 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.83 0.39 3.41e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6866344 0.697 rs11739893 chr5:178127837 G/A cg03877680 chr5:178157825 ZNF354A 0.79 14.52 0.5 1.76e-41 Neutrophil percentage of white cells; BRCA cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg01874867 chr7:94954059 PON1 -0.4 -8.13 -0.31 2.25e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2243480 1.000 rs4718333 chr7:65772758 T/C cg18252515 chr7:66147081 NA 1.06 15.89 0.53 3.65e-48 Diabetic kidney disease; BRCA cis rs7131987 0.903 rs2194520 chr12:29423712 C/T cg09582351 chr12:29534625 ERGIC2 -0.43 -10.48 -0.38 7.76e-24 QT interval; BRCA cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg09877947 chr5:131593287 PDLIM4 0.34 8.38 0.31 3.28e-16 Blood metabolite levels; BRCA cis rs11098499 0.909 rs28668716 chr4:120309875 T/C cg09307838 chr4:120376055 NA 0.74 16.02 0.54 8.36e-49 Corneal astigmatism; BRCA cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg06212747 chr3:49208901 KLHDC8B 0.53 8.17 0.31 1.65e-15 Menarche (age at onset); BRCA cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs2836633 0.859 rs8132069 chr21:40032611 T/C cg05519781 chr21:40033154 ERG 0.38 8.29 0.31 6.89e-16 Coronary artery disease; BRCA cis rs910316 0.789 rs175444 chr14:75601782 G/C cg08847533 chr14:75593920 NEK9 -0.8 -19.02 -0.6 3.1e-64 Height; BRCA cis rs12474201 0.630 rs897529 chr2:46948175 T/C cg06386533 chr2:46925753 SOCS5 0.58 12.54 0.44 2.06e-32 Height; BRCA trans rs9929218 0.953 rs16260 chr16:68771034 C/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -16.34 -0.54 2.04e-50 Colorectal cancer; BRCA cis rs67460515 0.563 rs11717272 chr3:160810355 A/G cg03342759 chr3:160939853 NMD3 -0.69 -13.91 -0.48 1.32e-38 Parkinson's disease; BRCA cis rs6728642 1.000 rs116171118 chr2:97695036 C/A cg26665480 chr2:98280029 ACTR1B -0.69 -8.34 -0.31 4.62e-16 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs9467160 0.532 rs2744565 chr6:24458461 G/T cg20631270 chr6:24437470 GPLD1 -0.43 -8.55 -0.32 9.07e-17 Liver enzyme levels; BRCA cis rs3820928 1.000 rs59904960 chr2:227761269 T/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.81 -0.33 1.18e-17 Pulmonary function; BRCA cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg15448220 chr1:150897856 SETDB1 -0.35 -8.05 -0.3 4.17e-15 Melanoma; BRCA cis rs3809566 1.000 rs10851721 chr15:63332383 T/C cg12160578 chr15:63334699 TPM1 -0.42 -8.55 -0.32 9.03e-17 Platelet count; BRCA cis rs853679 0.517 rs9368554 chr6:28082711 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.93 -0.3 9.81e-15 Corneal astigmatism; BRCA cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg08085267 chr17:45401833 C17orf57 -0.56 -11.44 -0.41 1.1e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6570726 0.935 rs421268 chr6:145845558 A/T cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467773 1.000 rs10214634 chr6:26564582 T/A cg11502198 chr6:26597334 ABT1 0.48 9.61 0.36 1.58e-20 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs8180040 0.966 rs17476234 chr3:47326298 G/A cg27129171 chr3:47204927 SETD2 -0.7 -16.87 -0.56 4.27e-53 Colorectal cancer; BRCA cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg04450456 chr4:17643702 FAM184B 0.42 12.7 0.45 4.17e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg16482183 chr6:26056742 HIST1H1C 0.56 11.91 0.43 1.15e-29 Height; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg23708337 chr7:1209742 NA 0.49 8.26 0.31 8.64e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7917772 0.582 rs10786698 chr10:104378750 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.08 0.49 2.02e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs5758511 0.680 rs5758684 chr22:42649509 C/T cg00645731 chr22:42541494 CYP2D7P1 0.59 11.11 0.4 2.52e-26 Birth weight; BRCA trans rs3858145 0.588 rs4142049 chr10:70044452 C/A cg04882175 chr6:131122610 NA -0.34 -7.83 -0.3 1.99e-14 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg03452623 chr4:187889614 NA -0.3 -9.81 -0.36 2.83e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs11971779 0.680 rs1862879 chr7:139019951 A/G cg07862535 chr7:139043722 LUC7L2 0.39 10.3 0.38 3.91e-23 Diisocyanate-induced asthma; BRCA cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.78 0.48 4.93e-38 Coronary artery disease; BRCA cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 3.04e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg16339924 chr4:17578868 LAP3 0.67 16.21 0.54 9.04e-50 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs700651 0.789 rs5007118 chr2:198909738 G/C cg00792783 chr2:198669748 PLCL1 0.42 9.05 0.34 1.76e-18 Intracranial aneurysm; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg17158414 chr2:27665306 KRTCAP3 -0.34 -8.76 -0.33 1.69e-17 Total body bone mineral density; BRCA cis rs10484885 0.878 rs55750696 chr6:90552336 G/A cg13799429 chr6:90582589 CASP8AP2 -0.76 -9.47 -0.35 5.23e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7819412 0.505 rs17782554 chr8:11022106 C/G cg21775007 chr8:11205619 TDH -0.47 -9.38 -0.35 1.12e-19 Triglycerides; BRCA cis rs7523050 0.643 rs7551313 chr1:109399881 G/A cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs11958404 0.932 rs7706111 chr5:157416053 C/T cg05962755 chr5:157440814 NA 0.47 9.36 0.35 1.34e-19 IgG glycosylation; BRCA cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg08999081 chr20:33150536 PIGU -0.34 -8.7 -0.33 2.7e-17 Coronary artery disease; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -11.52 -0.41 4.96e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg09436375 chr6:42928200 GNMT 0.28 10.57 0.39 3.63e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1215050 0.782 rs6853916 chr4:98653387 C/T cg05340658 chr4:99064831 C4orf37 -0.44 -9.97 -0.37 7.4e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs317689 0.718 rs315130 chr12:69761444 T/C cg14784868 chr12:69753453 YEATS4 0.48 9.56 0.35 2.41e-20 Response to diuretic therapy; BRCA cis rs10876993 0.893 rs7979246 chr12:58092554 A/G cg18357645 chr12:58087776 OS9 0.46 12.98 0.46 2.23e-34 Celiac disease or Rheumatoid arthritis; BRCA cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.3 -0.44 2.28e-31 Developmental language disorder (linguistic errors); BRCA cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg08564027 chr20:61660810 NA 0.85 22.5 0.66 5.11e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg11845111 chr2:191398756 TMEM194B 0.79 15.25 0.52 5.19e-45 Diastolic blood pressure; BRCA cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.43e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6138458 1.000 rs7269416 chr20:24976196 T/G cg06937882 chr20:24974362 C20orf3 -0.48 -9.46 -0.35 5.84e-20 Blood protein levels; BRCA cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg21395723 chr22:39101663 GTPBP1 0.39 8.39 0.31 3.17e-16 Menopause (age at onset); BRCA cis rs6840360 0.571 rs11099823 chr4:152510565 T/G cg22705602 chr4:152727874 NA -0.32 -8.36 -0.31 4e-16 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.51 -0.47 9.38e-37 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg03433033 chr1:76189801 ACADM 0.66 11.9 0.43 1.24e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6942756 0.806 rs6467237 chr7:128964831 A/G cg02491457 chr7:128862824 NA -0.57 -12.11 -0.43 1.53e-30 White matter hyperintensity burden; BRCA cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.43e-84 Chronic sinus infection; BRCA cis rs4363385 0.747 rs4240866 chr1:152954875 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.96e-16 Inflammatory skin disease; BRCA cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -9.53 -0.35 3.31e-20 Body mass index (adult); BRCA cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg09177884 chr7:1199841 ZFAND2A -0.6 -14.33 -0.49 1.35e-40 Longevity;Endometriosis; BRCA cis rs6598955 0.671 rs12116908 chr1:26587918 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg14558114 chr2:88469736 THNSL2 -0.42 -9.08 -0.34 1.36e-18 Response to metformin (IC50); BRCA cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg17063962 chr7:91808500 NA 0.52 12.38 0.44 1.01e-31 Breast cancer; BRCA cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA cis rs9633740 1.000 rs7097656 chr10:82250831 T/C cg01528321 chr10:82214614 TSPAN14 1.07 20.42 0.63 9.67e-72 Post bronchodilator FEV1; BRCA cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3772130 0.527 rs2141614 chr3:121590173 G/A cg20356878 chr3:121714668 ILDR1 0.44 10.09 0.37 2.67e-22 Cognitive performance; BRCA cis rs514406 0.760 rs475969 chr1:53292607 T/A cg24675658 chr1:53192096 ZYG11B -0.7 -16.25 -0.54 5.9e-50 Monocyte count; BRCA cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg18230493 chr5:56204884 C5orf35 -0.87 -16.72 -0.55 2.41e-52 Initial pursuit acceleration; BRCA cis rs10129255 0.500 rs6576232 chr14:107195328 A/G cg07958169 chr14:107095056 NA -0.39 -8.44 -0.32 2.05e-16 Kawasaki disease; BRCA cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg06784218 chr1:46089804 CCDC17 0.51 12.17 0.43 8.34e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504073 0.584 rs10957356 chr8:49980634 G/A cg00325661 chr8:49890786 NA 0.44 12.82 0.45 1.2e-33 Blood metabolite ratios; BRCA cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg19847866 chr10:1019161 NA 0.55 12.0 0.43 4.51e-30 Response to angiotensin II receptor blocker therapy; BRCA trans rs9944715 0.954 rs36191490 chr18:43839653 C/T cg01718231 chr17:29326311 RNF135 -0.44 -9.01 -0.34 2.36e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs6120849 0.518 rs11696652 chr20:33637060 T/G cg24642439 chr20:33292090 TP53INP2 0.6 10.36 0.38 2.45e-23 Protein C levels; BRCA cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg10057126 chr4:77819792 ANKRD56 0.67 15.28 0.52 3.62e-45 Emphysema distribution in smoking; BRCA cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg18351406 chr4:77819688 ANKRD56 0.58 12.68 0.45 5.27e-33 Emphysema distribution in smoking; BRCA cis rs919433 0.783 rs787980 chr2:198239225 C/T cg00792783 chr2:198669748 PLCL1 0.35 7.83 0.3 1.98e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs11098499 0.754 rs2036860 chr4:120248934 A/G cg09307838 chr4:120376055 NA 0.64 14.09 0.49 1.94e-39 Corneal astigmatism; BRCA cis rs8180040 0.620 rs1811652 chr3:47208698 C/G cg27129171 chr3:47204927 SETD2 -0.72 -17.52 -0.57 2.05e-56 Colorectal cancer; BRCA cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg24531977 chr5:56204891 C5orf35 -0.8 -16.79 -0.55 1.14e-52 Initial pursuit acceleration; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.39 -0.32 3e-16 Total body bone mineral density; BRCA cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg26850624 chr5:429559 AHRR 0.33 7.83 0.3 2.06e-14 Cystic fibrosis severity; BRCA trans rs12517041 1.000 rs13156787 chr5:23280382 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.45 -8.23 -0.31 1.09e-15 Calcium levels; BRCA cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.83 0.39 3.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.84e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.19 -0.31 1.45e-15 Aortic root size; BRCA cis rs56399783 0.901 rs73049341 chr7:2812255 G/C cg19731401 chr7:2775893 GNA12 0.48 8.34 0.31 4.49e-16 Childhood ear infection; BRCA cis rs7481584 0.624 rs397919 chr11:3063094 A/C cg08508325 chr11:3079039 CARS 0.28 8.48 0.32 1.56e-16 Calcium levels; BRCA cis rs2204008 0.748 rs8186658 chr12:38301461 A/C cg13010199 chr12:38710504 ALG10B 0.42 8.87 0.33 7.17e-18 Bladder cancer; BRCA cis rs7481584 0.624 rs449466 chr11:3047603 C/T cg08508325 chr11:3079039 CARS 0.28 8.49 0.32 1.5e-16 Calcium levels; BRCA cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg07148914 chr20:33460835 GGT7 0.43 9.24 0.34 3.69e-19 Height; BRCA cis rs1215050 0.791 rs165250 chr4:98696259 G/A cg05340658 chr4:99064831 C4orf37 0.45 10.18 0.37 1.21e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4642101 0.765 rs9872103 chr3:12827452 G/T cg24848339 chr3:12840334 CAND2 0.44 11.59 0.42 2.62e-28 QRS complex (12-leadsum); BRCA cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg15212455 chr7:39170539 POU6F2 0.4 9.1 0.34 1.1e-18 IgG glycosylation; BRCA cis rs2625529 0.824 rs12917428 chr15:72221998 T/C cg16672083 chr15:72433130 SENP8 -0.84 -17.34 -0.57 1.67e-55 Red blood cell count; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.1 0.34 1.12e-18 Tonsillectomy; BRCA cis rs9814567 0.806 rs12637301 chr3:134317966 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9811920 0.809 rs6806323 chr3:99722564 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -13.16 -0.46 3.55e-35 Axial length; BRCA cis rs586533 0.881 rs590634 chr11:99500333 A/C cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs11764590 0.694 rs56072378 chr7:2104364 A/G cg23422044 chr7:1970798 MAD1L1 -0.41 -8.71 -0.33 2.68e-17 Neuroticism; BRCA cis rs72928364 0.860 rs13085636 chr3:100797104 G/A cg10123952 chr3:100791384 NA 0.58 8.36 0.31 3.8e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg27170947 chr2:26402098 FAM59B -0.88 -16.75 -0.55 1.71e-52 Gut microbiome composition (summer); BRCA cis rs66573146 0.572 rs67252699 chr4:6946411 A/G cg26116260 chr4:7069785 GRPEL1 -0.59 -8.93 -0.33 4.43e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.46 0.38 9.36e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.61 0.32 5.64e-17 Rheumatoid arthritis; BRCA cis rs11098499 0.644 rs7693919 chr4:120540571 G/A cg09307838 chr4:120376055 NA 0.59 12.12 0.43 1.43e-30 Corneal astigmatism; BRCA cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.22 0.44 5.45e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg05234568 chr11:5960015 NA -0.44 -9.15 -0.34 7.49e-19 DNA methylation (variation); BRCA cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9467773 0.620 rs2494701 chr6:26634432 C/T cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.68e-30 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.79e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.31e-16 Menopause (age at onset); BRCA trans rs1422110 0.572 rs6884343 chr5:85444051 G/T cg01787110 chr1:109008453 NBPF6 0.4 8.54 0.32 9.94e-17 Attention function in attention deficit hyperactive disorder; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg24101359 chr6:42928495 GNMT 0.65 16.2 0.54 1.08e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs870825 0.616 rs7680639 chr4:185652915 C/T cg04058563 chr4:185651563 MLF1IP -0.73 -15.84 -0.53 6.2e-48 Blood protein levels; BRCA trans rs61931739 0.517 rs7958755 chr12:34294699 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.51 0.35 3.76e-20 Morning vs. evening chronotype; BRCA cis rs9325144 0.625 rs12227353 chr12:38734542 C/T cg26384229 chr12:38710491 ALG10B -0.52 -12.39 -0.44 9.86e-32 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs10445791 chr2:201078307 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.59 -8.63 -0.32 4.76e-17 Schizophrenia; BRCA cis rs701145 0.585 rs1713828 chr3:153838553 C/T cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA trans rs3733585 0.673 rs6850143 chr4:9958924 T/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2204008 0.775 rs8186812 chr12:38305055 C/T cg06521331 chr12:34319734 NA -0.46 -8.57 -0.32 7.48e-17 Bladder cancer; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg21280719 chr6:42927975 GNMT -0.33 -14.2 -0.49 5.89e-40 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs911555 0.723 rs6575982 chr14:103862681 G/A cg12935359 chr14:103987150 CKB 0.61 14.06 0.49 2.58e-39 Intelligence (multi-trait analysis); BRCA cis rs701145 0.556 rs355756 chr3:154021063 G/A cg16511985 chr3:153974050 SGEF 0.46 10.61 0.39 2.52e-24 Coronary artery disease; BRCA cis rs7715811 1.000 rs12153762 chr5:13778890 A/G cg07548982 chr5:13769939 DNAH5 -0.41 -9.09 -0.34 1.19e-18 Subclinical atherosclerosis traits (other); BRCA cis rs7607369 0.536 rs7600248 chr2:219665963 C/T cg02176678 chr2:219576539 TTLL4 -0.37 -10.09 -0.37 2.49e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7412746 0.658 rs3843843 chr1:150918084 C/T cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.19e-14 Melanoma; BRCA cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.19e-24 Chronic sinus infection; BRCA cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg20503657 chr10:835505 NA 1.32 21.46 0.65 2.31e-77 Eosinophil percentage of granulocytes; BRCA cis rs17253792 0.822 rs79262019 chr14:56092704 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -10.46 -0.38 9.67e-24 Extrinsic epigenetic age acceleration; BRCA cis rs514406 0.708 rs514881 chr1:53336737 A/G cg08859206 chr1:53392774 SCP2 0.59 12.95 0.46 3.02e-34 Monocyte count; BRCA cis rs829883 0.738 rs249846 chr12:98868739 T/C cg25150519 chr12:98850993 NA 0.69 16.75 0.55 1.68e-52 Colorectal adenoma (advanced); BRCA cis rs34779708 0.931 rs7920095 chr10:35303334 G/A cg03585969 chr10:35415529 CREM 0.56 11.59 0.42 2.64e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs12472274 0.646 rs35468889 chr2:239090959 G/A cg17459225 chr2:239074497 NA 0.59 10.62 0.39 2.35e-24 Phospholipid levels (plasma); BRCA cis rs593982 0.777 rs72941015 chr11:65457514 A/C cg08755490 chr11:65554678 OVOL1 -1.23 -14.64 -0.5 4.77e-42 Atopic dermatitis; BRCA cis rs7814319 0.838 rs10955067 chr8:97230982 C/T cg20787634 chr8:97240163 UQCRB -0.45 -10.48 -0.38 8.28e-24 Lung function (FVC); BRCA cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg03264133 chr6:25882463 NA 0.72 16.86 0.55 4.87e-53 Blood metabolite levels; BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg14196790 chr5:131705035 SLC22A5 0.34 9.13 0.34 8.61e-19 Breast cancer; BRCA cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg03264133 chr6:25882463 NA -0.53 -11.95 -0.43 7.44e-30 Blood metabolite levels; BRCA cis rs7246657 1.000 rs1529957 chr19:37739801 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.12 0.34 9.48e-19 Coronary artery calcification; BRCA cis rs36051895 0.594 rs10115464 chr9:5144268 C/T cg02405213 chr9:5042618 JAK2 -0.45 -8.63 -0.32 4.8e-17 Pediatric autoimmune diseases; BRCA cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg16339924 chr4:17578868 LAP3 0.55 13.7 0.48 1.24e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4363385 0.747 rs946098 chr1:152975038 A/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.54 -0.35 2.94e-20 Inflammatory skin disease; BRCA cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg11764359 chr7:65958608 NA -0.75 -16.87 -0.55 4.61e-53 Aortic root size; BRCA trans rs4596713 0.508 rs7862404 chr9:71779903 G/A cg16512924 chr15:28394682 HERC2 0.45 10.58 0.39 3.12e-24 Headache; BRCA cis rs3106136 0.527 rs4693376 chr4:95157240 A/G cg11021082 chr4:95130006 SMARCAD1 -0.39 -8.21 -0.31 1.21e-15 Capecitabine sensitivity; BRCA cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA trans rs4650994 0.525 rs2493865 chr1:178545016 G/A cg05059571 chr16:84539110 KIAA1609 0.54 12.5 0.44 3.11e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7267979 0.966 rs2257712 chr20:25264910 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg24549020 chr5:56110836 MAP3K1 0.5 10.44 0.38 1.15e-23 Type 2 diabetes; BRCA cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9325144 0.671 rs7485963 chr12:38768254 C/G cg26384229 chr12:38710491 ALG10B -0.51 -12.1 -0.43 1.7e-30 Morning vs. evening chronotype; BRCA cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg02297831 chr4:17616191 MED28 0.38 8.85 0.33 8.39e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg11707556 chr5:10655725 ANKRD33B 0.43 9.63 0.36 1.4e-20 Coronary artery disease; BRCA cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg14403583 chr14:105418241 AHNAK2 -0.38 -8.84 -0.33 8.9e-18 Rheumatoid arthritis; BRCA trans rs7395662 0.571 rs1605358 chr11:48689318 T/A cg00717180 chr2:96193071 NA -0.32 -8.73 -0.33 2.2e-17 HDL cholesterol; BRCA cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.55 10.88 0.4 1.99e-25 Tonsillectomy; BRCA cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg00321850 chr1:175162397 KIAA0040 -0.41 -11.47 -0.41 8.16e-28 Alcohol dependence; BRCA trans rs62103177 0.525 rs62101233 chr18:77724288 C/T cg05926928 chr17:57297772 GDPD1 0.64 9.12 0.34 9.95e-19 Opioid sensitivity; BRCA cis rs708547 0.581 rs6554400 chr4:57805306 A/C cg25525207 chr4:57843836 C4orf14;POLR2B 0.44 8.57 0.32 7.56e-17 Response to bleomycin (chromatid breaks); BRCA cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg24562669 chr7:97807699 LMTK2 0.47 11.93 0.43 9.16e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs10751667 0.666 rs6597967 chr11:950583 G/T ch.11.42038R chr11:967971 AP2A2 0.5 15.89 0.53 3.78e-48 Alzheimer's disease (late onset); BRCA cis rs7666738 0.606 rs4699606 chr4:99095074 A/C cg17366294 chr4:99064904 C4orf37 -0.36 -7.81 -0.3 2.38e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs597539 0.652 rs569777 chr11:68706848 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 18.43 0.59 3.6e-61 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg18132916 chr6:79620363 NA -0.49 -11.09 -0.4 3.06e-26 Intelligence (multi-trait analysis); BRCA cis rs4780401 0.728 rs8191335 chr16:11771353 C/A cg01061890 chr16:11836724 TXNDC11 -0.39 -8.32 -0.31 5.44e-16 Rheumatoid arthritis; BRCA cis rs7607369 0.782 rs514799 chr2:219411203 A/G cg02176678 chr2:219576539 TTLL4 0.46 11.97 0.43 6.17e-30 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs300703 0.935 rs417829 chr2:206851 A/G cg21211680 chr2:198530 NA 0.46 7.92 0.3 1.05e-14 Blood protein levels; BRCA cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 8.98 0.33 3.05e-18 Bipolar disorder; BRCA trans rs7773004 0.601 rs13210340 chr6:26326314 G/C cg01620082 chr3:125678407 NA -0.84 -9.24 -0.34 3.71e-19 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI in non-smokers;Waist circumference adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs1401999 0.510 rs3749438 chr3:183705184 G/A cg01324343 chr3:183735012 ABCC5 0.44 9.79 0.36 3.62e-21 Anterior chamber depth; BRCA trans rs11098499 0.779 rs10016060 chr4:120298412 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg05868516 chr6:26286170 HIST1H4H 0.46 9.22 0.34 4.37e-19 Educational attainment; BRCA cis rs4711336 0.967 rs4713658 chr6:33667117 C/G cg14003231 chr6:33640908 ITPR3 0.33 8.02 0.3 5.01e-15 Height; BRCA cis rs7647973 1.000 rs13096474 chr3:49443081 C/T cg07636037 chr3:49044803 WDR6 -0.73 -15.52 -0.52 2.44e-46 Menarche (age at onset); BRCA trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.21 -0.37 8.6e-23 Intelligence (multi-trait analysis); BRCA cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg11584989 chr19:19387371 SF4 -0.65 -14.15 -0.49 9.63e-40 Bipolar disorder; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg14863265 chr7:2801509 GNA12 -0.47 -10.14 -0.37 1.72e-22 Height; BRCA cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -9.29 -0.34 2.44e-19 Eosinophil percentage of white cells; BRCA trans rs61931739 0.534 rs10844767 chr12:34152368 C/G cg26384229 chr12:38710491 ALG10B 0.68 14.47 0.5 3.08e-41 Morning vs. evening chronotype; BRCA cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.83e-22 Bladder cancer; BRCA cis rs3768617 0.510 rs2093984 chr1:183094314 T/C ch.1.3577855R chr1:183094577 LAMC1 0.62 16.06 0.54 5.55e-49 Fuchs's corneal dystrophy; BRCA cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg12310025 chr6:25882481 NA -0.54 -12.03 -0.43 3.44e-30 Intelligence (multi-trait analysis); BRCA cis rs1371614 0.632 rs6738528 chr2:27149258 T/A cg00617064 chr2:27272375 NA 0.32 8.37 0.31 3.52e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs887829 0.570 rs10175809 chr2:234596865 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.36 -0.31 3.83e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs514406 0.505 rs427319 chr1:53178807 T/G cg24675658 chr1:53192096 ZYG11B -0.66 -14.52 -0.5 1.71e-41 Monocyte count; BRCA cis rs2880765 0.545 rs17553734 chr15:86013059 C/G cg10818794 chr15:86012489 AKAP13 0.42 11.31 0.41 3.58e-27 Coronary artery disease; BRCA cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg16339924 chr4:17578868 LAP3 0.61 14.99 0.51 9.23e-44 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg11789530 chr4:8429930 ACOX3 0.6 14.93 0.51 1.83e-43 Response to antineoplastic agents; BRCA cis rs59918340 1.000 rs59918340 chr8:142232256 A/G cg23750338 chr8:142222470 SLC45A4 0.4 9.77 0.36 4.15e-21 Immature fraction of reticulocytes; BRCA cis rs6964587 0.773 rs62467797 chr7:91889722 G/A cg01689657 chr7:91764605 CYP51A1 0.24 8.31 0.31 5.93e-16 Breast cancer; BRCA cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg03264133 chr6:25882463 NA -0.4 -8.6 -0.32 5.97e-17 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.31 0.41 3.82e-27 Height; BRCA cis rs9837602 1.000 rs4075038 chr3:99680086 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -11.28 -0.41 4.78e-27 Breast cancer; BRCA cis rs7917772 0.560 rs729023 chr10:104341887 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.48 -14.38 -0.49 7.92e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg08999081 chr20:33150536 PIGU 0.36 9.32 0.35 1.81e-19 Coronary artery disease; BRCA cis rs11920090 0.858 rs66674286 chr3:170679289 T/C cg09710316 chr3:170744871 SLC2A2 0.51 8.2 0.31 1.35e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs2425143 1.000 rs7264414 chr20:34446826 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.54 -0.32 9.92e-17 Blood protein levels; BRCA cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.25 0.56 5.13e-55 Electrocardiographic conduction measures; BRCA cis rs1483121 0.808 rs11039482 chr11:48009074 C/T cg20307385 chr11:47447363 PSMC3 0.56 7.92 0.3 1.07e-14 Fasting blood glucose (BMI interaction);Fasting blood glucose; BRCA cis rs5758511 0.689 rs5758691 chr22:42668504 G/C cg00645731 chr22:42541494 CYP2D7P1 0.58 11.18 0.4 1.24e-26 Birth weight; BRCA trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs6700896 0.931 rs12021623 chr1:66153586 A/C cg04111102 chr1:66153794 NA 0.41 9.87 0.36 1.83e-21 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6840360 0.615 rs113052419 chr4:152473008 T/C cg22705602 chr4:152727874 NA -0.32 -8.26 -0.31 8.6e-16 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs13051529 chr21:32029743 G/C cg14062083 chr21:31802829 KRTAP13-4 0.33 8.72 0.33 2.45e-17 HDL cholesterol; BRCA cis rs10197940 0.662 rs2432945 chr2:152278414 T/C cg06191203 chr2:152266755 RIF1 -0.31 -9.11 -0.34 1.08e-18 Lung cancer; BRCA cis rs7267979 0.932 rs6037125 chr20:25463382 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.37 0.31 3.74e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg26384229 chr12:38710491 ALG10B 0.7 15.92 0.53 2.66e-48 Bladder cancer; BRCA cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg24675658 chr1:53192096 ZYG11B 0.56 12.75 0.45 2.42e-33 Monocyte count; BRCA cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg17971929 chr21:40555470 PSMG1 -0.61 -13.72 -0.48 9.54e-38 Cognitive function; BRCA cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg17691542 chr6:26056736 HIST1H1C 0.74 14.71 0.5 2.08e-42 Iron status biomarkers; BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg16606324 chr3:10149918 C3orf24 0.55 10.86 0.39 2.38e-25 Alzheimer's disease; BRCA cis rs250677 0.687 rs384979 chr5:148459267 C/T cg12140854 chr5:148520817 ABLIM3 0.43 9.16 0.34 6.77e-19 Breast cancer; BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26314531 chr2:26401878 FAM59B -0.79 -12.6 -0.45 1.18e-32 Gut microbiome composition (summer); BRCA cis rs11971779 0.793 rs11764426 chr7:139024050 C/G cg07862535 chr7:139043722 LUC7L2 0.45 11.78 0.42 4.19e-29 Diisocyanate-induced asthma; BRCA cis rs875971 0.964 rs778721 chr7:65845397 C/G cg11764359 chr7:65958608 NA 0.81 19.67 0.61 1.05e-67 Aortic root size; BRCA cis rs9612 1.000 rs346524 chr19:44260572 T/C cg08581076 chr19:44259116 C19orf61 0.53 9.72 0.36 6.46e-21 Exhaled nitric oxide output; BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg04267008 chr7:1944627 MAD1L1 -0.45 -9.53 -0.35 3.12e-20 Schizophrenia; BRCA cis rs4076764 0.914 rs4638099 chr1:163365521 A/G cg06092702 chr1:163392909 NA 0.37 9.86 0.36 1.88e-21 Motion sickness; BRCA cis rs1577917 0.917 rs35738006 chr6:86646309 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -7.83 -0.3 2.04e-14 Response to antipsychotic treatment; BRCA cis rs7254114 0.578 rs35248735 chr19:11312238 G/A cg02815516 chr19:11306319 KANK2 -0.35 -10.01 -0.37 5.37e-22 Immature fraction of reticulocytes; BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg14062083 chr21:31802829 KRTAP13-4 0.35 9.54 0.35 2.85e-20 HDL cholesterol; BRCA cis rs1003719 0.788 rs2835584 chr21:38460338 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.59 13.62 0.47 2.93e-37 Eye color traits; BRCA cis rs2066819 1.000 rs11171806 chr12:56733531 A/G cg26734620 chr12:56694298 CS -0.89 -10.37 -0.38 2.07e-23 Psoriasis vulgaris; BRCA cis rs250677 0.687 rs384979 chr5:148459267 C/T cg23229984 chr5:148520753 ABLIM3 -0.36 -9.04 -0.34 1.8e-18 Breast cancer; BRCA cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg07828340 chr4:882639 GAK 0.99 13.58 0.47 4.13e-37 Intelligence (multi-trait analysis); BRCA cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg25817165 chr18:72167213 CNDP2 -0.75 -14.82 -0.51 6.34e-43 Refractive error; BRCA cis rs7766436 0.614 rs60412116 chr6:22563741 G/T cg13666174 chr6:22585274 NA -0.41 -8.63 -0.32 4.72e-17 Coronary artery disease; BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg08888203 chr3:10149979 C3orf24 -0.62 -13.57 -0.47 4.78e-37 Alzheimer's disease; BRCA cis rs12368653 0.525 rs1564374 chr12:58010163 C/T cg12615879 chr12:58013172 SLC26A10 0.32 9.05 0.34 1.75e-18 Multiple sclerosis; BRCA cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.55 -0.32 8.79e-17 Developmental language disorder (linguistic errors); BRCA cis rs12579753 0.917 rs7306043 chr12:82191282 G/A cg07988820 chr12:82153109 PPFIA2 -0.51 -8.83 -0.33 1.03e-17 Resting heart rate; BRCA cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg18758796 chr5:131593413 PDLIM4 0.31 8.12 0.31 2.35e-15 Blood metabolite levels; BRCA cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs13102973 0.899 rs7438900 chr4:135909921 T/A cg14419869 chr4:135874104 NA 0.46 8.99 0.34 2.81e-18 Subjective well-being; BRCA cis rs3739998 0.509 rs61841115 chr10:30333025 C/T cg00730780 chr10:30316187 KIAA1462 0.56 10.75 0.39 6.95e-25 Coronary heart disease; BRCA cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.43 7.86 0.3 1.6e-14 Mean platelet volume; BRCA trans rs61931739 0.534 rs11052984 chr12:34045904 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.22 0.31 1.1e-15 Morning vs. evening chronotype; BRCA cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg12373951 chr3:133503437 NA 0.34 8.1 0.31 2.73e-15 Iron status biomarkers; BRCA cis rs61931739 0.500 rs28624237 chr12:34457171 G/T cg06521331 chr12:34319734 NA -0.56 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs9517320 0.534 rs3858776 chr13:99161457 C/T cg20487152 chr13:99095054 FARP1 -0.3 -7.89 -0.3 1.33e-14 Longevity; BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -11.64 -0.42 1.62e-28 Alzheimer's disease; BRCA cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg04166393 chr7:2884313 GNA12 0.43 9.26 0.34 2.95e-19 Height; BRCA cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.88 -0.3 1.43e-14 Intelligence (multi-trait analysis); BRCA cis rs9435341 1.000 rs1762484 chr1:107613923 A/C cg09367891 chr1:107599246 PRMT6 -0.55 -10.08 -0.37 2.94e-22 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg22903471 chr2:27725779 GCKR 0.35 8.45 0.32 1.94e-16 Total body bone mineral density; BRCA cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg02753203 chr1:228287806 NA -0.72 -15.73 -0.53 2.34e-47 Diastolic blood pressure; BRCA cis rs4268898 0.529 rs4426488 chr2:24372815 A/G cg06627628 chr2:24431161 ITSN2 0.42 8.68 0.32 3.17e-17 Asthma; BRCA cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg08601574 chr20:25228251 PYGB 0.39 8.95 0.33 3.74e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11229555 0.609 rs4519113 chr11:58216825 T/C cg15696309 chr11:58395628 NA -0.45 -9.6 -0.35 1.79e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg01579765 chr21:45077557 HSF2BP -0.4 -10.76 -0.39 6.05e-25 Mean corpuscular volume; BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg21784768 chr11:537496 LRRC56 -0.64 -8.28 -0.31 7.08e-16 Body mass index; BRCA cis rs2251381 0.750 rs2776250 chr21:30528094 T/G cg08807101 chr21:30365312 RNF160 0.62 13.46 0.47 1.59e-36 Selective IgA deficiency; BRCA cis rs12541635 0.966 rs62525734 chr8:106984056 T/C cg10147462 chr8:107024639 NA 0.38 10.07 0.37 3.14e-22 Age of smoking initiation; BRCA cis rs61931739 0.500 rs11053260 chr12:34530215 T/G cg06521331 chr12:34319734 NA -0.53 -10.29 -0.38 4.23e-23 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg11814155 chr7:99998594 ZCWPW1 0.57 9.77 0.36 4.13e-21 Platelet count; BRCA cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg03433033 chr1:76189801 ACADM -0.47 -9.84 -0.36 2.25e-21 Daytime sleep phenotypes; BRCA trans rs61931739 0.534 rs7302688 chr12:34235064 A/G cg13010199 chr12:38710504 ALG10B 0.49 9.61 0.36 1.57e-20 Morning vs. evening chronotype; BRCA cis rs9818758 0.607 rs3923475 chr3:49055788 G/T cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs3845702 0.877 rs12693216 chr2:180839793 T/A cg01881094 chr2:180872142 CWC22 -0.69 -13.7 -0.48 1.18e-37 Schizophrenia; BRCA cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 8.21e-41 Motion sickness; BRCA trans rs12517041 1.000 rs35411935 chr5:23282784 T/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg00409905 chr10:38381863 ZNF37A -0.5 -10.44 -0.38 1.18e-23 Extrinsic epigenetic age acceleration; BRCA cis rs7043114 0.525 rs6479419 chr9:95110002 T/C cg14631576 chr9:95140430 CENPP -0.34 -8.38 -0.31 3.29e-16 Height; BRCA cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg18016565 chr1:150552671 MCL1 0.34 8.11 0.31 2.61e-15 Melanoma; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg08470875 chr2:26401718 FAM59B 0.72 11.89 0.43 1.31e-29 Gut microbiome composition (summer); BRCA cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg02574844 chr11:5959923 NA -0.4 -8.22 -0.31 1.11e-15 DNA methylation (variation); BRCA cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg08917208 chr2:24149416 ATAD2B 0.92 13.6 0.47 3.66e-37 Lymphocyte counts; BRCA cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg11530693 chr1:120165357 ZNF697 0.63 15.57 0.52 1.44e-46 Systemic lupus erythematosus; BRCA cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 11.55 0.42 3.54e-28 Personality dimensions; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.66 -0.59 2.46e-62 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9549367 0.577 rs3024718 chr13:113813853 C/T cg18105134 chr13:113819100 PROZ 0.71 15.07 0.51 3.77e-44 Platelet distribution width; BRCA cis rs6963495 0.818 rs75116202 chr7:105160059 C/T cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.61 -0.32 5.61e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7582180 0.652 rs11675901 chr2:100951189 G/A cg08017756 chr2:100939284 LONRF2 -0.31 -7.98 -0.3 6.56e-15 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg03923535 chr7:1197113 ZFAND2A 0.47 10.29 0.38 4.58e-23 Longevity;Endometriosis; BRCA cis rs3784262 0.692 rs1822205 chr15:58284657 C/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.9 -0.36 1.32e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.7e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4423214 0.840 rs1792224 chr11:71176141 C/T cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs6484504 0.625 rs4922859 chr11:31382517 A/G cg26647111 chr11:31128758 NA 0.42 9.34 0.35 1.5700000000000001e-19 Red blood cell count; BRCA cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg22307297 chr20:60903441 LAMA5 -0.34 -9.33 -0.35 1.65e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs2073300 1.000 rs6137961 chr20:23443102 G/T cg12062639 chr20:23401060 NAPB 0.88 10.43 0.38 1.28e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs34779708 0.733 rs7914468 chr10:35548071 G/A cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.52 0.38 5.65e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4481887 0.893 rs9651175 chr1:248446888 G/T cg00666640 chr1:248458726 OR2T12 0.32 8.61 0.32 5.63e-17 Common traits (Other); BRCA trans rs8002861 0.664 rs1466005 chr13:44424210 T/C cg12856521 chr11:46389249 DGKZ 0.37 8.12 0.31 2.36e-15 Leprosy; BRCA cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.65 16.69 0.55 3.62e-52 Colorectal cancer; BRCA trans rs11098499 0.789 rs12498994 chr4:120250818 A/C cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA cis rs7809950 0.678 rs77395658 chr7:107000651 G/A cg23024343 chr7:107201750 COG5 -0.48 -9.65 -0.36 1.17e-20 Coronary artery disease; BRCA cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -11.97 -0.43 6.14e-30 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg21475434 chr5:93447410 FAM172A 0.71 8.82 0.33 1.05e-17 Diabetic retinopathy; BRCA cis rs11031096 0.782 rs11031110 chr11:4162652 G/C cg18678763 chr11:4115507 RRM1 -0.37 -8.35 -0.31 4.08e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.96 -0.37 7.88e-22 Alzheimer's disease; BRCA cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 11.46 0.41 8.86e-28 Height; BRCA cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg18404041 chr3:52824283 ITIH1 -0.35 -9.0 -0.34 2.6e-18 Schizophrenia; BRCA cis rs4919694 1.000 rs17787717 chr10:104695699 T/G cg04362960 chr10:104952993 NT5C2 0.99 13.51 0.47 9.53e-37 Arsenic metabolism; BRCA cis rs724568 0.546 rs6717648 chr2:67939688 C/T cg17945962 chr2:67939740 NA -0.38 -10.19 -0.37 1.09e-22 Major depressive disorder (broad); BRCA cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs634534 0.622 rs552130 chr11:65732800 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 11.15 0.4 1.69e-26 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs9457247 0.510 rs6456151 chr6:167471851 A/C cg07741184 chr6:167504864 NA 0.33 9.8 0.36 3.25e-21 Crohn's disease; BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 11.17 0.4 1.43e-26 Platelet count; BRCA cis rs1997103 1.000 rs2331065 chr7:55408392 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg02551604 chr5:131831745 NA 0.4 15.16 0.51 1.43e-44 Asthma (sex interaction); BRCA cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg04727924 chr7:799746 HEATR2 -0.55 -10.78 -0.39 5.25e-25 Cerebrospinal P-tau181p levels; BRCA cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg15704280 chr7:45808275 SEPT13 -0.55 -10.73 -0.39 7.9e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs17376456 0.569 rs10076965 chr5:93094972 G/A cg25358565 chr5:93447407 FAM172A 0.69 11.87 0.42 1.73e-29 Diabetic retinopathy; BRCA trans rs9329221 0.662 rs4240645 chr8:10254463 C/G cg06636001 chr8:8085503 FLJ10661 -0.46 -8.81 -0.33 1.14e-17 Neuroticism; BRCA cis rs7903847 0.642 rs10882914 chr10:99142057 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7267979 0.844 rs6107017 chr20:25232300 A/G cg08601574 chr20:25228251 PYGB 0.41 9.62 0.36 1.49e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.59 9.33 0.35 1.67e-19 Renal function-related traits (BUN); BRCA cis rs1997103 0.954 rs2030807 chr7:55378485 A/G cg17469321 chr7:55412551 NA 0.51 9.52 0.35 3.5e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7572733 0.534 rs700678 chr2:198705820 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.15 0.37 1.55e-22 Dermatomyositis; BRCA cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.36 0.35 1.36e-19 Motion sickness; BRCA cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.4 8.38 0.31 3.4e-16 Total cholesterol levels; BRCA cis rs9486715 0.793 rs2499777 chr6:97013814 T/C cg06623918 chr6:96969491 KIAA0776 -0.92 -27.31 -0.73 1.98e-109 Headache; BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 11.31 0.41 3.77e-27 Tonsillectomy; BRCA cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg04450456 chr4:17643702 FAM184B -0.33 -9.39 -0.35 1.04e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg05340658 chr4:99064831 C4orf37 0.61 14.6 0.5 7.16e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs778371 0.522 rs10205801 chr2:233597196 G/A cg08000102 chr2:233561755 GIGYF2 0.7 17.06 0.56 4.79e-54 Schizophrenia; BRCA cis rs514406 1.000 rs514406 chr1:53330458 A/G cg16325326 chr1:53192061 ZYG11B 0.6 13.11 0.46 6.12e-35 Monocyte count; BRCA cis rs9287719 0.674 rs12620209 chr2:10720441 T/C cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.52e-19 Prostate cancer; BRCA cis rs877282 0.898 rs11253352 chr10:766598 C/A cg17470449 chr10:769945 NA 0.47 8.08 0.3 3.26e-15 Uric acid levels; BRCA trans rs7618501 0.633 rs12485600 chr3:50025530 A/G cg21659725 chr3:3221576 CRBN 0.5 12.72 0.45 3.48e-33 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs999943 0.846 rs9348923 chr6:33617924 C/T cg14003231 chr6:33640908 ITPR3 0.64 14.24 0.49 3.79e-40 Obesity (extreme); BRCA cis rs453301 0.686 rs3989373 chr8:8911308 G/T cg15556689 chr8:8085844 FLJ10661 -0.35 -9.38 -0.35 1.16e-19 Joint mobility (Beighton score); BRCA cis rs826838 0.967 rs2069211 chr12:39128892 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg27279351 chr12:120934652 DYNLL1 0.55 13.11 0.46 6.1e-35 High light scatter reticulocyte count; BRCA cis rs10174077 0.687 rs4664491 chr2:152479986 C/T cg06191203 chr2:152266755 RIF1 -0.34 -9.05 -0.34 1.76e-18 Squamous cell lung carcinoma; BRCA cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.42 8.95 0.33 3.79e-18 IgG glycosylation; BRCA cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg03146154 chr1:46216737 IPP -0.44 -9.62 -0.36 1.5e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2718798 1 rs2718798 chr3:133492088 A/C cg16414030 chr3:133502952 NA -0.34 -8.08 -0.3 3.17e-15 Ankle injury; BRCA cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.81 -0.36 2.98e-21 Alzheimer's disease (late onset); BRCA cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg08000102 chr2:233561755 GIGYF2 0.62 13.68 0.48 1.47e-37 Coronary artery disease; BRCA cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg11057378 chr10:81107060 PPIF 0.43 10.35 0.38 2.66e-23 Height; BRCA cis rs12541635 0.966 rs4734895 chr8:107002604 A/G cg10147462 chr8:107024639 NA 0.38 9.95 0.37 8.45e-22 Age of smoking initiation; BRCA cis rs4924935 0.770 rs4924946 chr17:18846525 A/T cg26378065 chr17:18585709 ZNF286B -0.35 -8.22 -0.31 1.14e-15 Pancreatic cancer; BRCA cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg01483505 chr11:975446 AP2A2 0.33 9.05 0.34 1.7e-18 Alzheimer's disease (late onset); BRCA cis rs1355223 0.506 rs11032898 chr11:34870111 C/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.38 -0.35 1.1e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.59 0.39 2.9e-24 IgG glycosylation; BRCA cis rs2444217 0.872 rs2531977 chr16:4043701 C/G cg09300795 chr16:4042428 ADCY9 0.49 11.6 0.42 2.34e-28 Body mass index; BRCA cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg12560992 chr17:57184187 TRIM37 -0.67 -18.01 -0.58 6e-59 Intelligence (multi-trait analysis); BRCA cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg08859206 chr1:53392774 SCP2 0.44 9.39 0.35 1.07e-19 Monocyte count; BRCA cis rs6910061 1.000 rs13214777 chr6:11103597 C/G cg27233058 chr6:11094804 LOC221710 0.53 9.37 0.35 1.27e-19 Diabetic kidney disease; BRCA cis rs4642101 0.765 rs4321514 chr3:12825901 C/T cg05775895 chr3:12838266 CAND2 0.35 7.97 0.3 7.39e-15 QRS complex (12-leadsum); BRCA trans rs826838 0.684 rs12367400 chr12:38618673 G/T cg06521331 chr12:34319734 NA -0.51 -9.34 -0.35 1.53e-19 Heart rate; BRCA cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg01262667 chr19:19385393 TM6SF2 -0.41 -10.61 -0.39 2.56e-24 Tonsillectomy; BRCA cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.38 7.95 0.3 8.39e-15 Total cholesterol levels; BRCA cis rs2882667 0.690 rs288013 chr5:138195817 A/G cg04439458 chr5:138467593 SIL1 0.31 7.94 0.3 9.16e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4595586 0.505 rs11615603 chr12:39409450 C/G cg26384229 chr12:38710491 ALG10B 0.43 9.61 0.36 1.69e-20 Morning vs. evening chronotype; BRCA cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg11502198 chr6:26597334 ABT1 -0.45 -9.13 -0.34 8.79e-19 Intelligence (multi-trait analysis); BRCA cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.29 0.31 6.67e-16 Breast cancer; BRCA cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg06552810 chr11:31128660 NA -0.37 -8.44 -0.32 2.12e-16 Red blood cell count; BRCA cis rs711245 0.545 rs848617 chr2:36811298 G/C cg09467607 chr2:36825704 FEZ2 0.57 14.0 0.48 4.76e-39 Height; BRCA cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs9815354 0.812 rs60796012 chr3:41908668 T/C cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2408955 0.522 rs7139330 chr12:48483484 A/C cg24011408 chr12:48396354 COL2A1 -0.39 -7.84 -0.3 1.86e-14 Glycated hemoglobin levels; BRCA cis rs1035144 0.506 rs2371416 chr14:81275672 A/T cg06600135 chr14:81408086 NA -0.43 -10.08 -0.37 2.84e-22 Male sexual orientation; BRCA cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.57 -0.32 7.58e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089829 0.962 rs1116450 chr20:61658210 T/C cg08045932 chr20:61659980 NA 0.5 11.21 0.41 9.24e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg03929089 chr4:120376271 NA 0.57 9.28 0.34 2.5e-19 Axial length; BRCA cis rs2346177 0.580 rs7565770 chr2:46683683 A/C cg02822958 chr2:46747628 ATP6V1E2 0.55 11.9 0.43 1.25e-29 HDL cholesterol; BRCA cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.78 0.33 1.48e-17 Motion sickness; BRCA cis rs9858542 0.953 rs6809216 chr3:49412559 G/A cg03060546 chr3:49711283 APEH -0.51 -10.51 -0.38 6.34e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg11057378 chr10:81107060 PPIF 0.43 10.3 0.38 4.18e-23 Height; BRCA cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg10811474 chr19:8428787 ANGPTL4 -0.33 -8.35 -0.31 4.18e-16 HDL cholesterol; BRCA cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg01475735 chr3:40494733 NA -0.43 -7.96 -0.3 7.63e-15 Renal cell carcinoma; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg16606324 chr3:10149918 C3orf24 0.53 10.09 0.37 2.68e-22 Alzheimer's disease; BRCA cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg11833968 chr6:79620685 NA -0.43 -9.55 -0.35 2.75e-20 Intelligence (multi-trait analysis); BRCA cis rs10189230 0.674 rs2710506 chr2:222379489 A/C cg14652038 chr2:222343519 EPHA4 0.33 8.03 0.3 4.64e-15 Urate levels in lean individuals; BRCA cis rs7635838 0.596 rs347598 chr3:11258289 G/C cg00170343 chr3:11313890 ATG7 0.42 8.53 0.32 1.03e-16 HDL cholesterol; BRCA cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.6 13.27 0.46 1.15e-35 Hemoglobin concentration; BRCA cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg16339924 chr4:17578868 LAP3 0.66 16.65 0.55 5.39e-52 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg13770153 chr20:60521292 NA -0.43 -9.73 -0.36 6.07e-21 Body mass index; BRCA cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14240646 chr10:27532245 ACBD5 -0.6 -9.93 -0.37 1.06e-21 Breast cancer; BRCA trans rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.56 -14.12 -0.49 1.28e-39 Brugada syndrome; BRCA cis rs9467773 1.000 rs767471 chr6:26557854 C/T cg09904177 chr6:26538194 HMGN4 0.55 17.67 0.57 3.26e-57 Intelligence (multi-trait analysis); BRCA cis rs595982 0.527 rs17206707 chr19:49361441 A/C cg21252483 chr19:49399788 TULP2 -0.39 -8.62 -0.32 5.41e-17 Red cell distribution width; BRCA cis rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05901451 chr6:126070800 HEY2 0.39 9.6 0.36 1.76e-20 Endometrial cancer; BRCA trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg13010199 chr12:38710504 ALG10B 0.42 9.01 0.34 2.3e-18 Morning vs. evening chronotype; BRCA cis rs72627509 0.951 rs6554401 chr4:57825336 C/G cg26694713 chr4:57773883 REST 0.48 9.22 0.34 4.37e-19 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs4820539 0.966 rs2267005 chr22:23461723 A/G cg14186256 chr22:23484241 RTDR1 0.74 22.01 0.66 2.53e-80 Bone mineral density; BRCA cis rs6963495 0.872 rs73190193 chr7:105164852 A/G cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.72 16.21 0.54 9.37e-50 Lymphocyte counts; BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg08888203 chr3:10149979 C3orf24 0.66 11.99 0.43 5.24e-30 Alzheimer's disease; BRCA trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -13.86 -0.48 2.11e-38 Extrinsic epigenetic age acceleration; BRCA cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg02773041 chr1:40204384 PPIE 0.43 9.25 0.34 3.34e-19 Blood protein levels; BRCA cis rs7258465 1.000 rs10409483 chr19:18590223 C/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.35 -0.31 4.35e-16 Breast cancer; BRCA cis rs1348850 0.958 rs4893941 chr2:178269531 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 10.09 0.37 2.67e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs868036 1.000 rs868036 chr15:68055013 T/A cg05925327 chr15:68127851 NA 0.34 8.54 0.32 9.66e-17 Restless legs syndrome; BRCA cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg17143192 chr8:8559678 CLDN23 0.52 10.03 0.37 4.5e-22 Obesity-related traits; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.71 -0.53 2.72e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs6500602 0.701 rs8053770 chr16:4539030 T/A cg08645402 chr16:4508243 NA 0.37 8.91 0.33 5.21e-18 Schizophrenia; BRCA cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.5 -9.4 -0.35 9.23e-20 Chronic sinus infection; BRCA cis rs7903847 0.642 rs11189179 chr10:99143320 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs752010 0.902 rs28635337 chr1:42101391 G/A cg06885757 chr1:42089581 HIVEP3 0.23 8.19 0.31 1.46e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6598955 0.671 rs11247908 chr1:26638222 G/A cg04990556 chr1:26633338 UBXN11 0.56 8.89 0.33 6.12e-18 Obesity-related traits; BRCA cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg10802521 chr3:52805072 NEK4 -0.32 -8.34 -0.31 4.67e-16 Bipolar disorder; BRCA trans rs8002861 0.967 rs2325071 chr13:44476793 T/C cg17145862 chr1:211918768 LPGAT1 0.69 18.17 0.58 8.7e-60 Leprosy; BRCA cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg20908204 chr19:46285434 DMPK -0.27 -8.01 -0.3 5.34e-15 Coronary artery disease; BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.12 0.31 2.38e-15 Tonsillectomy; BRCA cis rs651907 0.557 rs17347644 chr3:101547733 C/T cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.41 -0.32 2.67e-16 Colorectal cancer; BRCA cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg10523679 chr1:76189770 ACADM 0.78 18.69 0.59 1.61e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2832077 0.943 rs11700746 chr21:30189207 T/C cg24692254 chr21:30365293 RNF160 -0.46 -8.03 -0.3 4.54e-15 Cognitive test performance; BRCA cis rs3892630 0.824 rs2287882 chr19:33332952 C/T cg22980127 chr19:33182716 NUDT19 0.87 16.42 0.54 8.4e-51 Red blood cell traits; BRCA cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.75 16.26 0.54 5.12e-50 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs798554 0.660 rs798480 chr7:2805597 G/T cg19717773 chr7:2847554 GNA12 -0.42 -8.91 -0.33 5.1e-18 Height; BRCA cis rs2243480 1.000 rs35391607 chr7:65360829 G/A cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs757081 0.667 rs60173525 chr11:17259967 A/G cg15432903 chr11:17409602 KCNJ11 -0.46 -8.68 -0.32 3.25e-17 Systolic blood pressure; BRCA cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg24642439 chr20:33292090 TP53INP2 -0.52 -11.44 -0.41 1.04e-27 Glomerular filtration rate (creatinine); BRCA cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg18279126 chr7:2041391 MAD1L1 0.36 7.82 0.3 2.13e-14 Bipolar disorder and schizophrenia; BRCA cis rs2836633 0.929 rs2836602 chr21:40039169 A/T cg05519781 chr21:40033154 ERG -0.45 -9.56 -0.35 2.5e-20 Coronary artery disease; BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg20295408 chr7:1910781 MAD1L1 -0.34 -7.84 -0.3 1.94e-14 Bipolar disorder and schizophrenia; BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg25036284 chr2:26402008 FAM59B -0.8 -14.44 -0.5 4.05e-41 Gut microbiome composition (summer); BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.69 13.9 0.48 1.38e-38 Lymphocyte counts; BRCA cis rs2191566 1.000 rs2191566 chr19:44511389 A/C cg20607764 chr19:44506953 ZNF230 0.41 9.2 0.34 5.2e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs782590 0.783 rs7594279 chr2:55812073 T/G cg18811423 chr2:55921094 PNPT1 0.7 22.66 0.67 6.58e-84 Metabolic syndrome; BRCA cis rs4631830 0.863 rs2611507 chr10:51518673 T/C cg20129853 chr10:51489980 NA -0.29 -7.93 -0.3 9.53e-15 Prostate-specific antigen levels; BRCA cis rs1691799 0.867 rs1168316 chr12:66746239 A/G cg16791601 chr12:66731901 HELB -0.69 -19.67 -0.61 1.03e-67 White blood cell count (basophil); BRCA cis rs9368481 0.761 rs6918835 chr6:27017827 T/G cg12292205 chr6:26970375 C6orf41 -0.69 -15.0 -0.51 8.97e-44 Autism spectrum disorder or schizophrenia; BRCA cis rs7551345 0.687 rs881882 chr1:31697370 G/A cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA cis rs1065852 0.526 rs739296 chr22:42389948 A/G cg22189786 chr22:42395067 WBP2NL -0.41 -8.24 -0.31 9.99e-16 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg13271783 chr10:134563150 INPP5A -0.42 -9.02 -0.34 2.19e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6740322 0.895 rs10166994 chr2:43557977 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.14 -0.43 1.18e-30 Coronary artery disease; BRCA cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg24112000 chr20:60950667 NA -0.47 -9.26 -0.34 3.06e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs780096 0.546 rs2293571 chr2:27729480 C/T cg22903471 chr2:27725779 GCKR -0.35 -8.58 -0.32 7.35e-17 Total body bone mineral density; BRCA cis rs4664304 0.620 rs1397717 chr2:160720444 G/T cg14819504 chr2:160761413 LY75 0.34 8.47 0.32 1.65e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12762955 0.677 rs11250267 chr10:1156487 A/G cg20503657 chr10:835505 NA 0.56 9.54 0.35 2.92e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs1011018 0.628 rs17262676 chr7:139468828 C/T cg03224163 chr7:139420300 HIPK2 -0.59 -8.94 -0.33 4.08e-18 Systolic blood pressure; BRCA cis rs6964587 0.869 rs401 chr7:91527945 T/G cg17063962 chr7:91808500 NA -0.51 -11.89 -0.43 1.36e-29 Breast cancer; BRCA cis rs7246657 0.598 rs28660259 chr19:37658681 C/T cg23950597 chr19:37808831 NA -0.65 -9.89 -0.36 1.5e-21 Coronary artery calcification; BRCA cis rs7927771 0.524 rs10838777 chr11:47860954 A/C cg20307385 chr11:47447363 PSMC3 0.42 9.49 0.35 4.65e-20 Subjective well-being; BRCA cis rs12579753 0.827 rs7958100 chr12:82200782 G/A cg07988820 chr12:82153109 PPFIA2 -0.48 -8.33 -0.31 4.79e-16 Resting heart rate; BRCA cis rs4478858 0.684 rs1532861 chr1:31766491 T/C cg00250761 chr1:31883323 NA -0.32 -8.23 -0.31 1.09e-15 Alcohol dependence; BRCA cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg23711669 chr6:146136114 FBXO30 0.78 18.44 0.59 3.27e-61 Lobe attachment (rater-scored or self-reported); BRCA trans rs6479901 0.512 rs7082090 chr10:64999012 C/T cg14819942 chr15:35414228 NA 0.33 8.29 0.31 6.79e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg25036284 chr2:26402008 FAM59B -0.67 -10.99 -0.4 7.66e-26 Gut microbiome composition (summer); BRCA cis rs7647973 0.626 rs1078341 chr3:49685592 A/G cg03060546 chr3:49711283 APEH 0.58 10.19 0.37 1.08e-22 Menarche (age at onset); BRCA cis rs8062405 1.000 rs62036624 chr16:28839930 G/T cg09754948 chr16:28834200 ATXN2L 0.46 9.19 0.34 5.45e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg08000102 chr2:233561755 GIGYF2 -0.46 -10.01 -0.37 5.41e-22 Coronary artery disease; BRCA cis rs9325144 0.555 rs4882358 chr12:38726640 A/G cg26384229 chr12:38710491 ALG10B 0.48 12.29 0.44 2.61e-31 Morning vs. evening chronotype; BRCA cis rs1832871 0.672 rs9457344 chr6:158742043 C/T cg07165851 chr6:158734300 TULP4 0.63 12.61 0.45 9.95e-33 Height; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg00080972 chr5:178986291 RUFY1 0.52 14.39 0.49 7.48e-41 Lung cancer; BRCA trans rs61931739 0.517 rs10844815 chr12:34245150 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.54 0.35 3.01e-20 Morning vs. evening chronotype; BRCA cis rs9486719 1.000 rs4343922 chr6:96876903 C/T cg06623918 chr6:96969491 KIAA0776 0.72 14.29 0.49 2.11e-40 Migraine;Coronary artery disease; BRCA trans rs17685 0.753 rs13240967 chr7:75658197 C/T cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.06 -0.73 4.85e-108 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg08999081 chr20:33150536 PIGU 0.44 11.88 0.43 1.48e-29 Coronary artery disease; BRCA cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg02544614 chr20:61657117 NA 0.29 8.11 0.31 2.66e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1348850 0.872 rs4893824 chr2:178298104 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 8.58 0.32 7.08e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs887829 0.588 rs7556676 chr2:234658250 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -9.17 -0.34 6.59e-19 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg00012203 chr2:219082015 ARPC2 -0.46 -8.95 -0.33 3.91e-18 Colorectal cancer; BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.45 -0.41 9.33e-28 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs586533 0.881 rs668173 chr11:99499834 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6500602 0.826 rs7205189 chr16:4460114 A/G cg08645402 chr16:4508243 NA 0.39 8.5 0.32 1.29e-16 Schizophrenia; BRCA cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg15145296 chr3:125709740 NA -0.55 -8.7 -0.33 2.73e-17 Blood pressure (smoking interaction); BRCA cis rs9560113 1.000 rs9555804 chr13:112179751 T/C cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg23711669 chr6:146136114 FBXO30 0.74 17.43 0.57 5.6e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg13047869 chr3:10149882 C3orf24 0.54 11.55 0.42 3.64e-28 Alzheimer's disease; BRCA cis rs60780116 1 rs60780116 chr4:185708807 T/C cg04058563 chr4:185651563 MLF1IP 0.57 9.38 0.35 1.1e-19 Type 2 diabetes; BRCA cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg02466173 chr16:30829666 NA -0.42 -9.38 -0.35 1.13e-19 Dementia with Lewy bodies; BRCA cis rs698833 0.962 rs1085447 chr2:44670996 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.44 -9.0 -0.34 2.63e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7246657 0.943 rs1559229 chr19:37876197 T/C cg18154014 chr19:37997991 ZNF793 0.49 9.58 0.35 2.05e-20 Coronary artery calcification; BRCA cis rs7666738 0.546 rs34159897 chr4:98787367 T/C cg05340658 chr4:99064831 C4orf37 0.55 10.76 0.39 6.32e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg18964960 chr10:1102726 WDR37 0.6 8.05 0.3 4.2e-15 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.45 -9.26 -0.34 3.13e-19 Tonsillectomy; BRCA trans rs9858542 0.953 rs3811699 chr3:49396360 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.13 -0.34 9.04e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9831754 0.906 rs7611939 chr3:78392751 A/C cg06138941 chr3:78371609 NA -0.76 -16.59 -0.55 1.18e-51 Calcium levels; BRCA cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.77 0.48 5.88e-38 Coronary artery disease; BRCA trans rs4650994 1.000 rs10798619 chr1:178532517 A/G cg05059571 chr16:84539110 KIAA1609 -0.38 -8.51 -0.32 1.22e-16 HDL cholesterol levels;HDL cholesterol; BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg04025307 chr7:1156635 C7orf50 0.47 9.42 0.35 8.29e-20 Bronchopulmonary dysplasia; BRCA cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg04315214 chr1:2043799 PRKCZ 0.54 16.38 0.54 1.34e-50 Height; BRCA cis rs1865721 1.000 rs8094181 chr18:73193976 T/A cg26385618 chr18:73139727 C18orf62 -0.39 -9.0 -0.34 2.66e-18 Intelligence; BRCA cis rs1468333 1.000 rs10479179 chr5:137564115 A/G cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.51 0.32 1.21e-16 Resting heart rate; BRCA cis rs4595586 0.545 rs7308161 chr12:39363459 A/G cg26384229 chr12:38710491 ALG10B 0.43 9.48 0.35 4.78e-20 Morning vs. evening chronotype; BRCA cis rs1034435 0.755 rs5767172 chr22:48892314 A/C cg05992904 chr22:48892994 FAM19A5 -0.81 -21.16 -0.64 1.03e-75 Late-onset Alzheimer's disease; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg03188948 chr7:1209495 NA 0.67 11.33 0.41 2.99e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg05623727 chr3:50126028 RBM5 0.49 12.1 0.43 1.66e-30 Body mass index; BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg27170947 chr2:26402098 FAM59B 0.76 10.95 0.4 1.04e-25 Gut microbiome composition (summer); BRCA trans rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA cis rs367943 1.000 rs168365 chr5:112817984 G/A cg12552261 chr5:112820674 MCC -0.55 -12.1 -0.43 1.7e-30 Type 2 diabetes; BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg03609598 chr5:56110824 MAP3K1 -0.47 -8.22 -0.31 1.13e-15 Initial pursuit acceleration; BRCA cis rs12545109 0.879 rs2576588 chr8:57381627 G/A cg09654669 chr8:57350985 NA -0.42 -9.39 -0.35 1.04e-19 Obesity-related traits; BRCA cis rs9837602 1.000 rs9833888 chr3:99723580 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.21 0.41 9.09e-27 Breast cancer; BRCA cis rs7225537 0.559 rs7214429 chr17:17059872 A/G cg26176665 chr17:16994978 MPRIP -0.38 -8.49 -0.32 1.42e-16 Mean platelet volume; BRCA cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.33 0.31 5.05e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg23583168 chr7:148888333 NA 0.78 18.48 0.59 2.03e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg16405210 chr4:1374714 KIAA1530 -0.92 -20.74 -0.63 1.88e-73 Longevity; BRCA cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg20887711 chr4:1340912 KIAA1530 0.36 8.66 0.32 4e-17 Longevity; BRCA cis rs13223928 0.592 rs4722439 chr7:3155858 C/T cg19214707 chr7:3157722 NA 0.44 10.98 0.4 8.4e-26 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg26597838 chr10:835615 NA -0.51 -9.65 -0.36 1.14e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs2243480 1.000 rs313831 chr7:65551226 C/T cg18252515 chr7:66147081 NA -1.08 -15.14 -0.51 1.87e-44 Diabetic kidney disease; BRCA cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg22974920 chr21:40686053 BRWD1 -0.38 -8.76 -0.33 1.71e-17 Cognitive function; BRCA cis rs9527 0.662 rs10883783 chr10:104591152 T/A cg04362960 chr10:104952993 NT5C2 0.47 10.12 0.37 1.91e-22 Arsenic metabolism; BRCA cis rs3008870 1.000 rs2815357 chr1:67491854 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.93 20.76 0.63 1.49e-73 Lymphocyte percentage of white cells; BRCA trans rs800082 0.668 rs9821986 chr3:144292701 T/G cg24215973 chr2:240111563 HDAC4 -0.43 -10.32 -0.38 3.26e-23 Smoking behavior; BRCA cis rs7474896 0.616 rs1985260 chr10:38434090 C/T cg25427524 chr10:38739819 LOC399744 -0.59 -9.95 -0.37 8.54e-22 Obesity (extreme); BRCA cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs4363385 0.818 rs12085426 chr1:153003074 C/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.24 -0.31 9.85e-16 Inflammatory skin disease; BRCA cis rs11190604 1.000 rs10883506 chr10:102289743 C/G cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg17509989 chr5:176798049 RGS14 0.67 13.13 0.46 5.08e-35 Hemoglobin concentration;Hematocrit; BRCA cis rs875971 0.830 rs427575 chr7:65519219 A/G cg11764359 chr7:65958608 NA 0.76 17.46 0.57 4.2e-56 Aortic root size; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg00106254 chr7:1943704 MAD1L1 -0.33 -8.22 -0.31 1.12e-15 Schizophrenia; BRCA cis rs7729447 0.804 rs4867471 chr5:32693456 A/T cg16267343 chr5:32710456 NPR3 0.41 8.27 0.31 7.85e-16 Blood pressure; BRCA cis rs9309473 0.950 rs11689588 chr2:73773691 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -11.71 -0.42 8.08e-29 Metabolite levels; BRCA cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg01689657 chr7:91764605 CYP51A1 0.21 7.87 0.3 1.48e-14 Breast cancer; BRCA cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg07636037 chr3:49044803 WDR6 0.98 29.34 0.76 1.6e-120 Parkinson's disease; BRCA cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg16850897 chr7:100343110 ZAN -0.6 -12.61 -0.45 9.91e-33 Other erythrocyte phenotypes; BRCA cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11890956 chr21:40555474 PSMG1 -0.8 -18.89 -0.6 1.44e-63 Cognitive function; BRCA cis rs910316 1.000 rs876402 chr14:75601862 C/T cg23033748 chr14:75592666 NEK9 -0.41 -9.86 -0.36 1.84e-21 Height; BRCA cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg06784218 chr1:46089804 CCDC17 0.49 11.58 0.42 2.67e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.26 0.61 1.53e-65 Alzheimer's disease; BRCA cis rs7582180 0.629 rs11123826 chr2:100936276 G/T cg14675211 chr2:100938903 LONRF2 -0.52 -11.96 -0.43 6.89e-30 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.43 -10.06 -0.37 3.38e-22 Lymphocyte counts; BRCA cis rs12540874 0.698 rs10899736 chr7:50546925 C/T cg18232548 chr7:50535776 DDC -0.55 -14.1 -0.49 1.7e-39 Systemic sclerosis; BRCA cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.791 rs28858828 chr4:98950442 C/G cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.77e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg15017067 chr4:17643749 FAM184B 0.32 9.95 0.37 8.95e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg13628971 chr7:2884303 GNA12 0.38 8.53 0.32 1.08e-16 Height; BRCA cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg24112000 chr20:60950667 NA -0.58 -12.74 -0.45 2.82e-33 Colorectal cancer; BRCA cis rs34779708 0.741 rs34397613 chr10:35550313 A/G cg03585969 chr10:35415529 CREM 0.41 8.3 0.31 6.18e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg23018236 chr17:30244563 NA -0.63 -10.05 -0.37 3.77e-22 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs11252926 0.605 rs10904075 chr10:425667 A/G cg18196295 chr10:418757 DIP2C -0.61 -12.98 -0.46 2.35e-34 Psychosis in Alzheimer's disease; BRCA cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg21573476 chr21:45109991 RRP1B -0.37 -9.49 -0.35 4.48e-20 Mean corpuscular volume; BRCA cis rs2108225 0.872 rs2051954 chr7:107441097 G/C cg18560240 chr7:107437656 SLC26A3 -0.55 -11.52 -0.41 5.01e-28 Ulcerative colitis; BRCA trans rs3780486 0.846 rs10971419 chr9:33124161 T/C cg20290983 chr6:43655470 MRPS18A 1.12 41.82 0.86 4.22e-185 IgG glycosylation; BRCA cis rs758324 0.947 rs72793241 chr5:131240885 C/T cg06307176 chr5:131281290 NA -0.57 -11.95 -0.43 7.26e-30 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14240646 chr10:27532245 ACBD5 -0.64 -9.4 -0.35 9.32e-20 Breast cancer; BRCA cis rs10504073 0.631 rs341813 chr8:50039916 T/C cg00325661 chr8:49890786 NA 0.38 10.85 0.39 2.85e-25 Blood metabolite ratios; BRCA cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg04476341 chr5:669733 TPPP 0.39 7.83 0.3 2.02e-14 Lung disease severity in cystic fibrosis; BRCA cis rs2370759 1.000 rs79487858 chr10:32616405 T/C cg01819863 chr10:32635814 EPC1 1.17 20.75 0.63 1.69e-73 Sexual dysfunction (female); BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.48 -8.72 -0.33 2.32e-17 Renal function-related traits (BUN); BRCA trans rs11098499 0.697 rs11941899 chr4:120382758 C/A cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs10046574 1.000 rs10046574 chr7:135170470 C/T cg27474649 chr7:135195673 CNOT4 0.61 8.89 0.33 6.04e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg17366294 chr4:99064904 C4orf37 0.43 10.02 0.37 4.67e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs1348850 0.574 rs11691740 chr2:178445161 A/G cg27490568 chr2:178487706 NA -0.42 -7.96 -0.3 7.89e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.16 -0.34 6.72e-19 Total body bone mineral density; BRCA trans rs3857536 0.813 rs7771569 chr6:66946717 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24308560 chr3:49941425 MST1R -0.4 -8.54 -0.32 9.6e-17 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.730 rs12505735 chr4:120532956 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.31 0.31 5.53e-16 Corneal astigmatism; BRCA cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg10932868 chr11:921992 NA 0.5 12.8 0.45 1.55e-33 Alzheimer's disease (late onset); BRCA cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg23711669 chr6:146136114 FBXO30 -0.64 -14.7 -0.5 2.5e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.902 rs1125462 chr6:146417832 A/G cg23711669 chr6:146136114 FBXO30 0.67 15.51 0.52 2.73e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs2279817 0.743 rs3766309 chr1:17977378 C/T cg21791023 chr1:18019539 ARHGEF10L -0.34 -9.53 -0.35 3.3e-20 Neuroticism; BRCA cis rs1865760 0.865 rs4478388 chr6:25953633 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 9.54 0.35 2.86e-20 Height; BRCA cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.48 0.5 2.79e-41 Motion sickness; BRCA cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg24692254 chr21:30365293 RNF160 -0.47 -10.33 -0.38 3.11e-23 Dental caries; BRCA cis rs6066835 0.850 rs3827042 chr20:47319307 G/A cg18078177 chr20:47281410 PREX1 0.69 8.04 0.3 4.49e-15 Multiple myeloma; BRCA cis rs9649465 1.000 rs7776792 chr7:123335350 C/T cg04330084 chr7:123175371 IQUB 0.33 9.01 0.34 2.3e-18 Migraine; BRCA cis rs7264396 0.690 rs2425175 chr20:34445563 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.45 -0.52 5.35e-46 Total cholesterol levels; BRCA cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg08085267 chr17:45401833 C17orf57 0.59 12.38 0.44 1.07e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6964587 1.000 rs7781066 chr7:91691946 G/T cg17063962 chr7:91808500 NA 0.54 12.75 0.45 2.53e-33 Breast cancer; BRCA cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg24562669 chr7:97807699 LMTK2 -0.39 -10.4 -0.38 1.7e-23 Prostate cancer (SNP x SNP interaction); BRCA cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg26446133 chr18:72167187 CNDP2 -0.79 -19.95 -0.62 3.38e-69 Refractive error; BRCA cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg12011299 chr4:100065546 ADH4 0.49 11.08 0.4 3.25e-26 Alcohol dependence; BRCA cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg08085267 chr17:45401833 C17orf57 -0.7 -15.4 -0.52 9.67e-46 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2880765 0.710 rs11630457 chr15:86004801 T/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.14 -0.31 2.01e-15 Coronary artery disease; BRCA cis rs59918340 0.728 rs6987335 chr8:142235358 T/G cg23750338 chr8:142222470 SLC45A4 -0.49 -11.17 -0.4 1.36e-26 Immature fraction of reticulocytes; BRCA cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg12311346 chr5:56204834 C5orf35 -0.81 -16.16 -0.54 1.65e-49 Initial pursuit acceleration; BRCA cis rs858239 0.539 rs6956828 chr7:23187347 A/G cg23682824 chr7:23144976 KLHL7 0.41 10.64 0.39 1.8e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs9486719 1.000 rs2499807 chr6:96864053 T/G cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA cis rs10751667 0.666 rs7395321 chr11:940280 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg27286337 chr10:134555280 INPP5A 0.64 10.75 0.39 6.79e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs739401 0.869 rs395188 chr11:3072631 A/G cg25174290 chr11:3078921 CARS -0.36 -10.69 -0.39 1.22e-24 Longevity; BRCA cis rs250677 0.522 rs10042466 chr5:148393634 T/C cg18129178 chr5:148520854 ABLIM3 -0.52 -10.13 -0.37 1.78e-22 Breast cancer; BRCA cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg23719950 chr11:63933701 MACROD1 -0.58 -9.62 -0.36 1.48e-20 Mean platelet volume; BRCA cis rs6121246 0.511 rs879982 chr20:30398510 A/G cg13852791 chr20:30311386 BCL2L1 0.95 23.13 0.68 1.89e-86 Mean corpuscular hemoglobin; BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13126279 chr21:47581558 C21orf56 -0.45 -10.17 -0.37 1.33e-22 Testicular germ cell tumor; BRCA cis rs6500602 0.627 rs841231 chr16:4583147 C/T cg08645402 chr16:4508243 NA -0.4 -9.52 -0.35 3.49e-20 Schizophrenia; BRCA cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg12386194 chr3:101231763 SENP7 0.46 9.65 0.36 1.12e-20 Colorectal cancer; BRCA cis rs2625529 0.775 rs62023342 chr15:72161305 A/C cg16672083 chr15:72433130 SENP8 -0.84 -17.51 -0.57 2.35e-56 Red blood cell count; BRCA cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg17063962 chr7:91808500 NA 0.54 12.69 0.45 4.49e-33 Breast cancer; BRCA cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg18279126 chr7:2041391 MAD1L1 0.37 7.96 0.3 7.67e-15 Bipolar disorder and schizophrenia; BRCA cis rs56104184 0.775 rs56146968 chr19:49398847 A/G cg15549821 chr19:49342101 PLEKHA4 -0.64 -9.51 -0.35 3.81e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.33 0.31 4.93e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7178424 0.806 rs4587915 chr15:62241962 C/T cg00456672 chr15:62358751 C2CD4A 0.36 8.93 0.33 4.46e-18 Height; BRCA cis rs4242434 0.927 rs2291231 chr8:22463912 C/T cg03733263 chr8:22462867 KIAA1967 0.97 23.58 0.68 6.65e-89 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg18132916 chr6:79620363 NA -0.46 -10.32 -0.38 3.24e-23 Intelligence (multi-trait analysis); BRCA cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.83 0.36 2.44e-21 Lung cancer in ever smokers; BRCA cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg09904177 chr6:26538194 HMGN4 0.51 14.83 0.51 5.59e-43 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.24 -0.41 7.23e-27 Gut microbiome composition (summer); BRCA cis rs2637266 1.000 rs12260379 chr10:78365036 C/T cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs7766436 0.885 rs7773749 chr6:22587190 C/G cg13666174 chr6:22585274 NA -0.5 -11.89 -0.43 1.36e-29 Coronary artery disease; BRCA cis rs4141404 0.923 rs2413035 chr22:31600460 A/G cg02404636 chr22:31891804 SFI1 -0.41 -8.75 -0.33 1.93e-17 Paclitaxel-induced neuropathy; BRCA cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg02734326 chr4:10020555 SLC2A9 0.36 7.98 0.3 6.97e-15 Bone mineral density; BRCA cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg10802521 chr3:52805072 NEK4 -0.34 -9.33 -0.35 1.73e-19 Intelligence (multi-trait analysis); BRCA cis rs9581857 0.685 rs9319373 chr13:28042835 A/G cg22138327 chr13:27999177 GTF3A 0.62 9.55 0.35 2.66e-20 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); BRCA cis rs7220401 0.789 rs4794859 chr17:27962393 A/C cg26525008 chr17:28256777 EFCAB5;SSH2 -0.5 -11.68 -0.42 1.07e-28 Coronary artery disease; BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg08805041 chr16:621841 PIGQ -0.3 -8.04 -0.3 4.5e-15 Height; BRCA trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg15556689 chr8:8085844 FLJ10661 0.4 10.14 0.37 1.7e-22 Triglycerides; BRCA cis rs6840360 0.571 rs12647566 chr4:152482525 C/T cg22705602 chr4:152727874 NA -0.32 -8.27 -0.31 7.76e-16 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.965 rs6796845 chr3:38567771 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -19.31 -0.61 8.57e-66 Electrocardiographic conduction measures; BRCA cis rs6570726 0.967 rs6903252 chr6:145922777 A/G cg23711669 chr6:146136114 FBXO30 0.7 16.79 0.55 1.07e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.619 rs28502463 chr4:120257023 T/C cg09307838 chr4:120376055 NA 0.63 13.48 0.47 1.22e-36 Corneal astigmatism; BRCA cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg11764359 chr7:65958608 NA 0.62 13.63 0.47 2.69e-37 Aortic root size; BRCA cis rs208520 0.690 rs12192851 chr6:66705862 G/C cg07460842 chr6:66804631 NA 0.97 19.47 0.61 1.26e-66 Exhaled nitric oxide output; BRCA cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg20933634 chr6:27740509 NA 0.48 9.61 0.36 1.64e-20 Parkinson's disease; BRCA cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -11.63 -0.42 1.78e-28 Monocyte percentage of white cells; BRCA cis rs61990749 0.597 rs1477262 chr14:78226653 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.82 0.36 2.75e-21 Fibroblast growth factor basic levels; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg23358479 chr7:1110784 C7orf50 -0.47 -7.94 -0.3 9.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9831754 0.526 rs11927217 chr3:78341723 A/G cg06138941 chr3:78371609 NA -0.41 -9.93 -0.37 1.03e-21 Calcium levels; BRCA cis rs17376456 0.877 rs12153506 chr5:93360953 T/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.0 0.3 6.07e-15 Diabetic retinopathy; BRCA cis rs4713118 0.662 rs9468274 chr6:28026077 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.46e-23 Chronic sinus infection; BRCA cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg17077180 chr1:38461687 NA 0.51 11.99 0.43 5.18e-30 Coronary artery disease; BRCA cis rs546131 0.928 rs483976 chr11:34840167 C/G cg06937548 chr11:34938143 PDHX;APIP 0.4 7.82 0.3 2.22e-14 Lung disease severity in cystic fibrosis; BRCA trans rs561341 1.000 rs484175 chr17:30309041 G/A cg20587970 chr11:113659929 NA -1.2 -22.15 -0.66 4.31e-81 Hip circumference adjusted for BMI; BRCA cis rs7727544 0.684 rs274546 chr5:131699867 A/G cg24060327 chr5:131705240 SLC22A5 -0.46 -9.26 -0.34 3.06e-19 Blood metabolite levels; BRCA cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg20933634 chr6:27740509 NA 0.47 9.3 0.35 2.17e-19 Parkinson's disease; BRCA cis rs6121246 0.512 rs6058384 chr20:30276409 A/T cg13852791 chr20:30311386 BCL2L1 0.96 23.31 0.68 2.03e-87 Mean corpuscular hemoglobin; BRCA cis rs36051895 0.664 rs10115172 chr9:5098549 C/T cg02405213 chr9:5042618 JAK2 -0.5 -8.88 -0.33 6.46e-18 Pediatric autoimmune diseases; BRCA cis rs652260 0.967 rs667295 chr19:7901634 G/A cg26014689 chr19:7917955 EVI5L -0.51 -11.68 -0.42 1.05e-28 Menarche (age at onset); BRCA cis rs9811920 0.965 rs10222474 chr3:99862551 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 12.76 0.45 2.31e-33 Axial length; BRCA cis rs7246657 0.722 rs16958861 chr19:38124179 G/A cg14683738 chr19:37701593 ZNF585B 0.47 7.98 0.3 6.94e-15 Coronary artery calcification; BRCA cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg06784218 chr1:46089804 CCDC17 0.47 11.27 0.41 5.43e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.32 0.54 2.57e-50 Smoking behavior; BRCA cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg08807892 chr2:162101083 NA 0.45 8.7 0.33 2.86e-17 Intelligence (multi-trait analysis); BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg18538332 chr22:24372958 LOC391322 -0.57 -14.53 -0.5 1.55e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7945705 0.791 rs4579928 chr11:8815704 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.47 10.45 0.38 1.09e-23 Hemoglobin concentration; BRCA cis rs2732480 0.577 rs2732479 chr12:48736260 A/C cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 6.07e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.65 -0.36 1.14e-20 Tonsillectomy; BRCA cis rs7246657 0.551 rs10407224 chr19:37651470 G/T cg23950597 chr19:37808831 NA -0.65 -9.88 -0.36 1.67e-21 Coronary artery calcification; BRCA cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg22800045 chr5:56110881 MAP3K1 0.4 8.05 0.3 4.05e-15 Coronary artery disease; BRCA cis rs6546886 0.957 rs4416242 chr2:74259894 A/T cg14702570 chr2:74259524 NA -0.32 -8.21 -0.31 1.22e-15 Dialysis-related mortality; BRCA trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg25214090 chr10:38739885 LOC399744 0.51 11.61 0.42 2.01e-28 Corneal astigmatism; BRCA cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.81 -19.17 -0.6 4.77e-65 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg03929089 chr4:120376271 NA 0.58 9.41 0.35 8.64e-20 Axial length; BRCA cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.2 0.34 4.89e-19 Height; BRCA cis rs6782228 0.606 rs1127030 chr3:128338953 T/C cg16766828 chr3:128327626 NA -0.42 -9.53 -0.35 3.29e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7582180 0.614 rs4340543 chr2:101005511 G/A cg14675211 chr2:100938903 LONRF2 0.43 9.78 0.36 3.77e-21 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg02659138 chr7:134003124 SLC35B4 0.33 10.5 0.38 6.78e-24 Mean platelet volume; BRCA cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg24296786 chr1:45957014 TESK2 0.64 15.92 0.53 2.57e-48 High light scatter reticulocyte count; BRCA cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg13256891 chr4:100009986 ADH5 0.51 10.67 0.39 1.41e-24 Alcohol dependence; BRCA cis rs12541635 0.899 rs1429676 chr8:107065790 G/A cg10147462 chr8:107024639 NA -0.33 -8.82 -0.33 1.05e-17 Age of smoking initiation; BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg04166393 chr7:2884313 GNA12 0.51 9.44 0.35 6.58e-20 Height; BRCA cis rs2732480 0.537 rs1061986 chr12:48736439 T/C cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 6.07e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg22676075 chr6:135203613 NA 0.44 8.66 0.32 3.73e-17 Red blood cell count; BRCA cis rs10463316 0.894 rs7729438 chr5:150762197 G/A cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs754466 0.606 rs7084705 chr10:79596675 A/G cg17075019 chr10:79541650 NA -0.77 -20.19 -0.62 1.67e-70 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17401966 1.000 rs2275424 chr1:10356562 C/A cg03954927 chr1:10346856 KIF1B 0.45 12.76 0.45 2.13e-33 Hepatocellular carcinoma; BRCA cis rs586533 0.757 rs657362 chr11:99501878 T/G cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.08 -0.4 3.14e-26 Schizophrenia; BRCA cis rs2282802 0.685 rs7737543 chr5:139646026 A/G cg26211634 chr5:139558579 C5orf32 0.35 8.39 0.31 3.17e-16 Intelligence (multi-trait analysis); BRCA cis rs7824557 0.778 rs6601572 chr8:11093337 C/G cg21775007 chr8:11205619 TDH -0.46 -9.24 -0.34 3.63e-19 Retinal vascular caliber; BRCA cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg11901034 chr3:128598214 ACAD9 0.37 9.01 0.34 2.43e-18 IgG glycosylation; BRCA cis rs2964802 0.505 rs10513058 chr5:10804383 C/T cg14521931 chr5:10832172 NA -0.56 -12.5 -0.44 3e-32 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.43 0.41 1.2100000000000001e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg20887711 chr4:1340912 KIAA1530 0.35 8.49 0.32 1.41e-16 Longevity; BRCA cis rs897080 0.515 rs698815 chr2:44706974 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.21 0.34 4.44e-19 Height; BRCA cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg26384229 chr12:38710491 ALG10B -0.58 -13.58 -0.47 4.59e-37 Bladder cancer; BRCA cis rs3813567 0.759 rs12594550 chr15:78959037 C/G cg04896959 chr15:78267971 NA 0.44 8.27 0.31 7.62e-16 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg23029597 chr12:123009494 RSRC2 -0.58 -11.56 -0.42 3.4e-28 Body mass index; BRCA cis rs490234 0.783 rs4838278 chr9:128403509 T/C cg14078157 chr9:128172775 NA -0.45 -10.32 -0.38 3.45e-23 Mean arterial pressure; BRCA cis rs2425143 1.000 rs7273815 chr20:34232415 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.7 -0.33 2.75e-17 Blood protein levels; BRCA cis rs9858542 1.000 rs13085791 chr3:49721798 C/A cg03060546 chr3:49711283 APEH -0.58 -11.74 -0.42 5.82e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg20607798 chr8:58055168 NA 0.47 8.32 0.31 5.26e-16 Developmental language disorder (linguistic errors); BRCA cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg09184832 chr6:79620586 NA -0.52 -11.4 -0.41 1.61e-27 Intelligence (multi-trait analysis); BRCA cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg18351406 chr4:77819688 ANKRD56 0.61 13.39 0.47 3.13e-36 Emphysema distribution in smoking; BRCA cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2066819 0.892 rs17118431 chr12:56667100 A/G cg26734620 chr12:56694298 CS 0.91 10.64 0.39 1.85e-24 Psoriasis vulgaris; BRCA cis rs9560113 0.843 rs9555808 chr13:112181284 A/T cg10483660 chr13:112241077 NA 0.32 7.98 0.3 6.63e-15 Menarche (age at onset); BRCA cis rs473651 0.935 rs515412 chr2:239345394 A/T cg03560586 chr2:239334908 ASB1 -0.51 -11.24 -0.41 6.92e-27 Multiple system atrophy; BRCA cis rs9463078 0.764 rs494982 chr6:44937255 C/T cg25276700 chr6:44698697 NA -0.34 -7.95 -0.3 8.39e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs11098499 0.754 rs12507565 chr4:120251121 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg23173402 chr1:227635558 NA -0.52 -9.51 -0.35 3.69e-20 Major depressive disorder; BRCA cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg02175503 chr12:58329896 NA 0.42 8.07 0.3 3.55e-15 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg05283184 chr6:79620031 NA -0.43 -10.89 -0.4 1.97e-25 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg02734326 chr4:10020555 SLC2A9 0.37 8.43 0.32 2.21e-16 Bone mineral density; BRCA cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg18964960 chr10:1102726 WDR37 0.6 8.21 0.31 1.26e-15 Eosinophil percentage of granulocytes; BRCA cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg23583168 chr7:148888333 NA -0.74 -16.17 -0.54 1.55e-49 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg22834771 chr12:69754056 YEATS4 -0.34 -7.92 -0.3 1.09e-14 Blood protein levels; BRCA cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg03146154 chr1:46216737 IPP -0.44 -9.62 -0.36 1.5e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -12.03 -0.43 3.51e-30 Alzheimer's disease; BRCA trans rs35110281 0.666 rs2838348 chr21:45107285 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.41 -8.36 -0.31 4.06e-16 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9921192 1.000 rs2892165 chr16:4324293 A/T cg00021532 chr16:4324280 TFAP4 0.59 16.29 0.54 3.71e-50 Prostate-specific antigen levels; BRCA cis rs1983170 0.736 rs745731 chr1:92011467 G/T cg25838465 chr1:92012736 NA 0.47 8.23 0.31 1.06e-15 Eosinophil percentage of white cells; BRCA cis rs6120849 0.754 rs36003887 chr20:33589107 G/A cg24642439 chr20:33292090 TP53INP2 0.58 10.12 0.37 2.05e-22 Protein C levels; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6032067 0.561 rs2743317 chr20:43936931 C/T cg20256260 chr20:43936981 MATN4;RBPJL 0.35 8.38 0.31 3.3e-16 Blood protein levels; BRCA cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg25110423 chr6:41068646 NFYA;LOC221442 0.4 9.58 0.35 2.04e-20 Alzheimer's disease (late onset); BRCA cis rs2836950 0.545 rs11700813 chr21:40517469 T/G cg11644478 chr21:40555479 PSMG1 -0.51 -10.53 -0.38 5.03e-24 Menarche (age at onset); BRCA cis rs4631830 0.720 rs12763717 chr10:51500874 C/G cg20129853 chr10:51489980 NA 0.32 8.63 0.32 4.85e-17 Prostate-specific antigen levels; BRCA cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg23649088 chr2:200775458 C2orf69 -0.61 -10.28 -0.38 5e-23 Schizophrenia; BRCA cis rs918629 0.530 rs17085249 chr5:95236415 C/T cg16656078 chr5:95278638 ELL2 -0.35 -8.34 -0.31 4.5e-16 IgG glycosylation; BRCA cis rs7267979 1.000 rs2258201 chr20:25272490 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17818399 0.645 rs35870739 chr2:46784231 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.42 -7.84 -0.3 1.96e-14 Height; BRCA trans rs6479891 1.000 rs9414788 chr10:65056712 A/G cg14819942 chr15:35414228 NA -0.34 -8.45 -0.32 1.9e-16 Arthritis (juvenile idiopathic); BRCA cis rs6542838 0.641 rs6760065 chr2:99486318 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.37 -8.24 -0.31 9.76e-16 Fear of minor pain; BRCA cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs6665290 0.935 rs1929862 chr1:227199718 G/A cg10327440 chr1:227177885 CDC42BPA -1.16 -49.86 -0.89 2.04e-222 Myeloid white cell count; BRCA cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.66 -0.5 3.76e-42 Chronic sinus infection; BRCA cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.6 0.39 2.59e-24 Mean corpuscular volume; BRCA cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -11.55 -0.42 3.72e-28 Glomerular filtration rate (creatinine); BRCA cis rs4908768 0.520 rs7520025 chr1:8698277 C/T cg20416874 chr1:8611966 RERE -0.3 -8.52 -0.32 1.13e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg12310025 chr6:25882481 NA 0.72 18.11 0.58 1.8e-59 Blood metabolite levels; BRCA cis rs7824557 0.701 rs4568582 chr8:11160495 A/T cg21775007 chr8:11205619 TDH 0.62 12.28 0.44 2.79e-31 Retinal vascular caliber; BRCA cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg15595755 chr5:1867978 NA 0.36 8.6 0.32 6.01e-17 Cardiovascular disease risk factors; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg14582100 chr15:45693742 SPATA5L1 0.37 11.66 0.42 1.32e-28 Homoarginine levels; BRCA cis rs243505 1.000 rs243521 chr7:148421571 T/C cg09806900 chr7:148480153 CUL1 -0.43 -8.82 -0.33 1.1e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9400271 0.504 rs9784763 chr6:109624937 A/G cg01475377 chr6:109611718 NA 0.41 9.89 0.36 1.53e-21 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg08917208 chr2:24149416 ATAD2B 0.91 13.38 0.47 3.55e-36 Lymphocyte counts; BRCA cis rs13046373 0.535 rs1354866 chr21:31981559 A/T cg14062083 chr21:31802829 KRTAP13-4 0.34 9.25 0.34 3.44e-19 HDL cholesterol; BRCA cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg24296786 chr1:45957014 TESK2 0.42 9.5 0.35 4.24e-20 Red blood cell count;Reticulocyte count; BRCA cis rs4820539 0.932 rs3788349 chr22:23467950 A/G cg14186256 chr22:23484241 RTDR1 0.78 23.94 0.69 6.75e-91 Bone mineral density; BRCA cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg03264133 chr6:25882463 NA -0.54 -11.24 -0.41 6.83e-27 Intelligence (multi-trait analysis); BRCA cis rs11030122 0.702 rs10835407 chr11:3993231 C/T cg18678763 chr11:4115507 RRM1 0.35 7.91 0.3 1.16e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05901451 chr6:126070800 HEY2 0.45 11.47 0.41 8.05e-28 Endometrial cancer; BRCA cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.03 -0.34 1.96e-18 Alzheimer's disease (late onset); BRCA cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg04117972 chr1:227635322 NA 0.52 9.34 0.35 1.5700000000000001e-19 Major depressive disorder; BRCA cis rs4243830 0.737 rs11122083 chr1:6593532 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.9 -15.38 -0.52 1.22e-45 Body mass index; BRCA cis rs912057 0.526 rs737449 chr6:6733729 A/G cg06612196 chr6:6737390 NA -0.54 -12.98 -0.46 2.26e-34 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs868036 0.522 rs3784711 chr15:68072527 C/T cg05925327 chr15:68127851 NA 0.31 7.9 0.3 1.18e-14 Restless legs syndrome; BRCA cis rs2749592 0.611 rs2505199 chr10:38392457 G/A cg00409905 chr10:38381863 ZNF37A -0.49 -9.03 -0.34 1.99e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg18016565 chr1:150552671 MCL1 0.34 8.12 0.31 2.43e-15 Tonsillectomy; BRCA cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg19717773 chr7:2847554 GNA12 0.46 10.55 0.39 4.38e-24 Height; BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.79 -0.36 3.42e-21 Schizophrenia; BRCA cis rs7267979 0.714 rs2474763 chr20:25241295 A/G cg08601574 chr20:25228251 PYGB 0.34 8.01 0.3 5.55e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6446731 0.593 rs2157090 chr4:3273110 C/T cg08886695 chr4:3369023 RGS12 -0.37 -9.7 -0.36 7.62e-21 Mean platelet volume; BRCA cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs10805346 0.558 rs12506562 chr4:10106954 G/T cg26043149 chr18:55253948 FECH 0.43 9.73 0.36 5.85e-21 Urate levels in overweight individuals;Urate levels in obese individuals; BRCA cis rs7539409 0.604 rs910183 chr1:84297285 A/G cg10977910 chr1:84465055 TTLL7 0.58 9.04 0.34 1.84e-18 Alzheimer's disease; BRCA cis rs2070488 0.965 rs1058945 chr3:38532511 A/G cg24069376 chr3:38537580 EXOG -0.42 -12.15 -0.43 1.01e-30 Electrocardiographic conduction measures; BRCA cis rs453301 0.686 rs11785634 chr8:8892597 G/T cg15556689 chr8:8085844 FLJ10661 -0.31 -8.11 -0.31 2.59e-15 Joint mobility (Beighton score); BRCA cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.41 8.92 0.33 4.93e-18 Colonoscopy-negative controls vs population controls; BRCA trans rs7980799 0.654 rs10844618 chr12:33625010 A/G cg26384229 chr12:38710491 ALG10B -0.49 -10.57 -0.39 3.57e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs920590 0.758 rs1826420 chr8:19664878 G/T cg03894339 chr8:19674705 INTS10 0.44 8.72 0.33 2.44e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg17366294 chr4:99064904 C4orf37 0.52 11.13 0.4 1.97e-26 Colonoscopy-negative controls vs population controls; BRCA trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.2 0.34 4.85e-19 Resting heart rate; BRCA cis rs7098414 0.511 rs4934126 chr10:82151598 A/G cg01528321 chr10:82214614 TSPAN14 0.67 14.17 0.49 8.12e-40 Post bronchodilator FEV1; BRCA cis rs9790314 0.521 rs60625846 chr3:161084525 G/T cg03342759 chr3:160939853 NMD3 -0.56 -11.93 -0.43 9.38e-30 Morning vs. evening chronotype; BRCA cis rs895636 0.848 rs4953156 chr2:45189763 G/A cg16198908 chr2:45192207 NA 0.48 8.89 0.33 6.13e-18 Metabolite levels;Fasting plasma glucose; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg27588902 chr6:42928151 GNMT -0.3 -9.85 -0.36 2.14e-21 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs908922 0.676 rs945788 chr1:152512762 A/G cg20991723 chr1:152506922 NA 0.38 8.82 0.33 1.05e-17 Hair morphology; BRCA cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs208520 0.634 rs3909071 chr6:66836947 T/C cg07460842 chr6:66804631 NA -1.01 -19.78 -0.62 2.57e-68 Exhaled nitric oxide output; BRCA cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg18876405 chr7:65276391 NA -0.66 -16.59 -0.55 1.09e-51 Aortic root size; BRCA cis rs2070488 1.000 rs13074160 chr3:38455650 G/T cg24069376 chr3:38537580 EXOG 0.4 11.4 0.41 1.51e-27 Electrocardiographic conduction measures; BRCA cis rs4820539 1.000 rs916585 chr22:23469438 G/A cg14186256 chr22:23484241 RTDR1 0.79 24.78 0.7 1.59e-95 Bone mineral density; BRCA cis rs9814567 0.928 rs6768323 chr3:134268737 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg12011299 chr4:100065546 ADH4 0.51 11.66 0.42 1.33e-28 Alcohol dependence; BRCA cis rs9914988 0.943 rs9893782 chr17:27108132 C/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg10845886 chr2:3471009 TTC15 -0.54 -11.99 -0.43 4.9e-30 Neurofibrillary tangles; BRCA cis rs9291683 0.567 rs12499857 chr4:9995376 G/A cg11266682 chr4:10021025 SLC2A9 0.47 12.35 0.44 1.48e-31 Bone mineral density; BRCA cis rs559928 0.606 rs61083753 chr11:63892665 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 9.24 0.34 3.7e-19 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -8.66 -0.32 3.84e-17 Longevity;Endometriosis; BRCA cis rs1707322 0.686 rs1541131 chr1:46084934 G/A cg06784218 chr1:46089804 CCDC17 -0.53 -12.82 -0.45 1.16e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg02353165 chr6:42928485 GNMT 0.88 23.77 0.69 5.73e-90 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg07148914 chr20:33460835 GGT7 -0.36 -7.93 -0.3 9.56e-15 Glomerular filtration rate (creatinine); BRCA cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg12311346 chr5:56204834 C5orf35 -0.81 -16.03 -0.54 7.58e-49 Initial pursuit acceleration; BRCA cis rs6910061 1.000 rs6910061 chr6:11101918 A/T cg27233058 chr6:11094804 LOC221710 -0.5 -8.95 -0.33 3.68e-18 Diabetic kidney disease; BRCA cis rs4730250 0.670 rs9641380 chr7:106868151 C/G cg02696742 chr7:106810147 HBP1 -0.51 -8.58 -0.32 7.04e-17 Osteoarthritis; BRCA cis rs9649465 0.561 rs2429618 chr7:123421662 G/A cg03229431 chr7:123269106 ASB15 0.44 10.17 0.37 1.25e-22 Migraine; BRCA cis rs12618769 0.543 rs56357378 chr2:99032455 T/G cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.01e-15 Bipolar disorder; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA trans rs1459104 1.000 rs35453180 chr11:55324915 G/A cg15704280 chr7:45808275 SEPT13 0.64 8.04 0.3 4.25e-15 Body mass index; BRCA cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg24130564 chr14:104152367 KLC1 0.39 8.48 0.32 1.55e-16 Reticulocyte count; BRCA cis rs757110 0.868 rs5219 chr11:17409572 T/C cg04705435 chr11:17411270 KCNJ11 0.45 9.35 0.35 1.44e-19 Type 2 diabetes; BRCA cis rs11098499 0.909 rs11723839 chr4:120299673 G/A cg09307838 chr4:120376055 NA 0.71 15.07 0.51 3.93e-44 Corneal astigmatism; BRCA cis rs3008870 1.000 rs3008859 chr1:67390999 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.49 0.65 1.62e-77 Lymphocyte percentage of white cells; BRCA cis rs11874712 0.965 rs8083998 chr18:43673144 A/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.09 0.3 2.98e-15 Migraine - clinic-based; BRCA cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs829883 0.646 rs4762494 chr12:98933834 T/G cg25150519 chr12:98850993 NA -0.5 -9.1 -0.34 1.1e-18 Colorectal adenoma (advanced); BRCA cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg02503808 chr4:7069936 GRPEL1 0.8 18.6 0.59 4.57e-62 Monocyte percentage of white cells; BRCA cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg26597838 chr10:835615 NA 1.02 17.86 0.58 3.47e-58 Eosinophil percentage of granulocytes; BRCA cis rs3857067 0.776 rs6858265 chr4:95112565 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs34779708 0.706 rs36027395 chr10:35550323 T/A cg03585969 chr10:35415529 CREM 0.43 8.58 0.32 7e-17 Inflammatory bowel disease;Crohn's disease; BRCA trans rs11764590 0.666 rs3996325 chr7:2053747 T/C cg11693508 chr17:37793320 STARD3 0.42 8.87 0.33 7.07e-18 Neuroticism; BRCA trans rs3857536 0.740 rs9360191 chr6:66942454 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs10788264 0.621 rs9633733 chr10:124056546 A/G cg09507567 chr10:124027408 NA -0.38 -8.03 -0.3 4.81e-15 Total body bone mineral density; BRCA cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg24596788 chr1:163392923 NA -0.4 -10.66 -0.39 1.53e-24 Motion sickness; BRCA cis rs11098499 0.863 rs59732491 chr4:120489588 G/C cg09307838 chr4:120376055 NA 0.69 13.84 0.48 2.79e-38 Corneal astigmatism; BRCA cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg27446573 chr6:127587934 RNF146 0.9 21.07 0.64 2.99e-75 Breast cancer; BRCA cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg10780632 chr17:43973522 MAPT;LOC100128977;LOC100130148 0.5 8.81 0.33 1.17e-17 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18758796 chr5:131593413 PDLIM4 0.39 9.94 0.37 9.96e-22 Acylcarnitine levels; BRCA cis rs9875589 0.509 rs2731337 chr3:14091440 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 9.04 0.34 1.83e-18 Ovarian reserve; BRCA cis rs503734 0.502 rs571391 chr3:100963154 C/T cg27318481 chr3:100970896 IMPG2 -0.39 -9.27 -0.34 2.9e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11890956 chr21:40555474 PSMG1 -0.84 -20.5 -0.63 3.55e-72 Cognitive function; BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg27170947 chr2:26402098 FAM59B -0.65 -11.16 -0.4 1.47e-26 Gut microbiome composition (summer); BRCA cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg19077165 chr18:44547161 KATNAL2 -0.37 -7.83 -0.3 2.09e-14 Educational attainment; BRCA cis rs753778 0.962 rs4961341 chr8:142235154 G/T cg18755752 chr8:142205143 DENND3 -0.42 -9.3 -0.35 2.21e-19 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg01191920 chr7:158217561 PTPRN2 0.46 11.06 0.4 3.71e-26 Obesity-related traits; BRCA cis rs798554 0.679 rs798499 chr7:2792013 G/A cg19717773 chr7:2847554 GNA12 -0.43 -9.48 -0.35 4.99e-20 Height; BRCA cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -14.07 -0.49 2.41e-39 Hemoglobin concentration; BRCA cis rs2629540 0.765 rs11245387 chr10:126537825 C/T cg08799069 chr10:126477246 METTL10 -0.35 -8.03 -0.3 4.78e-15 Cocaine dependence; BRCA cis rs1832871 0.599 rs1754413 chr6:158764741 C/T cg07215822 chr6:158701037 NA 0.47 9.64 0.36 1.29e-20 Height; BRCA cis rs611744 0.647 rs1448150 chr8:109276161 T/C cg21045802 chr8:109455806 TTC35 0.35 7.94 0.3 9.27e-15 Dupuytren's disease; BRCA cis rs1451375 0.652 rs7803903 chr7:50625945 C/T cg18232548 chr7:50535776 DDC 0.38 8.03 0.3 4.84e-15 Malaria; BRCA trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg15704280 chr7:45808275 SEPT13 -0.49 -9.64 -0.36 1.29e-20 HDL cholesterol; BRCA cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.55 -0.32 9.03e-17 Glomerular filtration rate (creatinine); BRCA cis rs877282 1.000 rs12219807 chr10:772870 A/C cg17470449 chr10:769945 NA 0.5 9.37 0.35 1.23e-19 Uric acid levels; BRCA cis rs870825 0.929 rs1405940 chr4:185591481 A/G cg04058563 chr4:185651563 MLF1IP 0.87 14.48 0.5 2.52e-41 Blood protein levels; BRCA cis rs9287719 0.934 rs12692418 chr2:10745870 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.84 0.39 2.96e-25 Cognitive ability; BRCA cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.84 0.36 2.29e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1949733 0.628 rs1543246 chr4:8504909 A/T cg13073564 chr4:8508604 NA -0.38 -10.44 -0.38 1.11e-23 Response to antineoplastic agents; BRCA cis rs67460515 0.500 rs9860537 chr3:160660500 G/T cg03342759 chr3:160939853 NMD3 0.59 11.78 0.42 3.81e-29 Parkinson's disease; BRCA cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg26384229 chr12:38710491 ALG10B 0.77 17.27 0.56 4.05e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 4.08e-15 Breast cancer; BRCA cis rs4965272 1.000 rs4965557 chr15:100583717 C/G cg27344315 chr15:100560801 ADAMTS17 -0.41 -8.66 -0.32 3.95e-17 Gastroesophageal reflux disease; BRCA cis rs6546550 0.901 rs897119 chr2:70160658 T/C cg02498382 chr2:70120550 SNRNP27 -0.52 -11.35 -0.41 2.54e-27 Prevalent atrial fibrillation; BRCA cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg06064525 chr11:970664 AP2A2 -0.49 -16.2 -0.54 1.11e-49 Alzheimer's disease (late onset); BRCA cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg02503808 chr4:7069936 GRPEL1 -0.79 -14.16 -0.49 8.68e-40 Monocyte percentage of white cells; BRCA cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs11608355 0.545 rs4766474 chr12:109908084 G/C cg05360138 chr12:110035743 NA 0.71 13.09 0.46 7.36e-35 Neuroticism; BRCA cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg23711669 chr6:146136114 FBXO30 0.69 16.01 0.54 9.25e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg10862848 chr6:42927986 GNMT -0.35 -14.74 -0.5 1.59e-42 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg16145915 chr7:1198662 ZFAND2A -0.42 -8.01 -0.3 5.52e-15 Bronchopulmonary dysplasia; BRCA cis rs11098499 0.710 rs6851130 chr4:120133712 G/A cg09307838 chr4:120376055 NA -0.49 -9.27 -0.34 2.75e-19 Corneal astigmatism; BRCA cis rs6066825 0.644 rs6066823 chr20:47338768 C/G cg18078177 chr20:47281410 PREX1 0.39 9.51 0.35 3.76e-20 Colorectal cancer; BRCA cis rs514406 0.505 rs374849 chr1:53185631 G/A cg24675658 chr1:53192096 ZYG11B -0.66 -14.29 -0.49 2.2e-40 Monocyte count; BRCA cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 13.97 0.48 7.08e-39 Colorectal cancer; BRCA cis rs7301826 0.627 rs4325342 chr12:131312482 G/A cg11011512 chr12:131303247 STX2 0.52 13.72 0.48 9.48e-38 Plasma plasminogen activator levels; BRCA cis rs1400816 0.850 rs2292814 chr2:172586567 A/G cg13550731 chr2:172543902 DYNC1I2 0.53 8.31 0.31 5.84e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.67 11.13 0.4 1.93e-26 Schizophrenia; BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs250677 0.522 rs10477400 chr5:148359598 T/C cg12140854 chr5:148520817 ABLIM3 0.4 8.13 0.31 2.3e-15 Breast cancer; BRCA cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3808502 0.527 rs4410870 chr8:11156120 C/G cg21775007 chr8:11205619 TDH -0.43 -8.18 -0.31 1.57e-15 Neuroticism; BRCA cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA cis rs9318086 0.712 rs9318099 chr13:24442462 C/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.31 -8.79 -0.33 1.35e-17 Myopia (pathological); BRCA cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.79 -18.71 -0.59 1.36e-62 Hip circumference adjusted for BMI; BRCA cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.55e-18 Motion sickness; BRCA cis rs4595586 0.545 rs7486598 chr12:39371159 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.4 0.35 9.62e-20 Morning vs. evening chronotype; BRCA cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3768617 0.510 rs2093985 chr1:183094322 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.72 0.55 2.66e-52 Fuchs's corneal dystrophy; BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg23285459 chr7:2802560 GNA12 -0.34 -8.62 -0.32 5.08e-17 Height; BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg27170947 chr2:26402098 FAM59B 0.93 16.85 0.55 5.51e-53 Gut microbiome composition (summer); BRCA cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.77 -0.45 2.07e-33 Bipolar disorder; BRCA cis rs939658 0.805 rs35291410 chr15:79438660 C/T cg17916960 chr15:79447300 NA -0.46 -11.6 -0.42 2.39e-28 Refractive error; BRCA cis rs6582630 0.638 rs61931383 chr12:38513845 G/A cg26384229 chr12:38710491 ALG10B -0.43 -10.05 -0.37 3.76e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs3741798 1.000 rs17375328 chr12:12485292 T/C cg08615371 chr12:12503544 MANSC1 1.07 15.32 0.52 2.35e-45 Cerebrospinal fluid biomarker levels; BRCA cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg22963979 chr7:1858916 MAD1L1 0.4 8.72 0.33 2.39e-17 Bipolar disorder and schizophrenia; BRCA cis rs7727544 0.557 rs2897096 chr5:131486284 A/G cg14196790 chr5:131705035 SLC22A5 0.37 9.21 0.34 4.52e-19 Blood metabolite levels; BRCA cis rs11105298 0.891 rs10858906 chr12:89934474 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.54 -0.35 3.02e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs60843830 0.964 rs17713568 chr2:242132 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 14.62 0.5 5.57e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.03 -0.4 5.04e-26 Lymphocyte counts; BRCA cis rs1577917 0.740 rs2758843 chr6:86328431 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.75 -0.45 2.45e-33 Response to antipsychotic treatment; BRCA cis rs868036 1.000 rs884202 chr15:68054388 G/A cg05925327 chr15:68127851 NA 0.34 8.54 0.32 9.66e-17 Restless legs syndrome; BRCA cis rs765787 0.530 rs1631533 chr15:45518628 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.42 -0.41 1.3e-27 Uric acid levels; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg23285459 chr7:2802560 GNA12 -0.38 -9.65 -0.36 1.16e-20 Height; BRCA cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg12573674 chr2:1569213 NA -0.48 -9.47 -0.35 5.36e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 7.85 0.3 1.78e-14 Mean platelet volume; BRCA cis rs10189230 0.967 rs13026378 chr2:222352712 G/A cg14652038 chr2:222343519 EPHA4 0.46 12.75 0.45 2.57e-33 Urate levels in lean individuals; BRCA cis rs9291683 0.546 rs4529049 chr4:10045389 C/T cg00071950 chr4:10020882 SLC2A9 0.56 13.52 0.47 7.89e-37 Bone mineral density; BRCA cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.78 -19.6 -0.61 2.49e-67 Systemic lupus erythematosus; BRCA cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg04455712 chr21:45112962 RRP1B 0.41 10.55 0.39 4.16e-24 Mean corpuscular volume; BRCA cis rs16854884 0.741 rs55909524 chr3:143794734 T/C cg06585982 chr3:143692056 C3orf58 0.39 7.81 0.3 2.33e-14 Economic and political preferences (feminism/equality); BRCA cis rs314370 0.951 rs13226502 chr7:100506381 C/T cg10426581 chr7:100472382 SRRT 0.63 9.79 0.36 3.4e-21 Resting heart rate; BRCA cis rs35740288 0.929 rs11636821 chr15:86306005 T/G cg20737812 chr15:86336631 KLHL25 -0.32 -7.95 -0.3 8.56e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg02389323 chr16:88786976 FAM38A 0.75 11.89 0.43 1.4e-29 Plateletcrit; BRCA cis rs654950 0.901 rs594656 chr1:41999873 C/T cg06885757 chr1:42089581 HIVEP3 -0.32 -10.47 -0.38 8.86e-24 Airway imaging phenotypes; BRCA trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg25482853 chr8:67687455 SGK3 0.97 15.32 0.52 2.31e-45 Lung disease severity in cystic fibrosis; BRCA cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.2 -0.49 5.76e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1784581 1.000 rs1615717 chr6:162400612 C/T cg17173639 chr6:162384350 PARK2 -0.44 -10.31 -0.38 3.6e-23 Itch intensity from mosquito bite; BRCA trans rs8002861 0.935 rs7319725 chr13:44445421 T/C cg17145862 chr1:211918768 LPGAT1 0.7 18.43 0.59 3.74e-61 Leprosy; BRCA cis rs11955398 0.625 rs286153 chr5:59928948 A/G cg02684056 chr5:59996105 DEPDC1B 0.35 8.3 0.31 6.11e-16 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.943 rs4802766 chr19:37981933 T/C cg18154014 chr19:37997991 ZNF793 0.64 12.26 0.44 3.56e-31 Coronary artery calcification; BRCA cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg05234568 chr11:5960015 NA 0.37 7.9 0.3 1.22e-14 DNA methylation (variation); BRCA cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg06484146 chr7:12443880 VWDE -0.74 -10.73 -0.39 8.46e-25 Coronary artery disease; BRCA cis rs3768617 0.510 rs3765522 chr1:183077618 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 18.08 0.58 2.46e-59 Fuchs's corneal dystrophy; BRCA cis rs4409675 0.576 rs2474470 chr1:28234999 C/T cg23691781 chr1:28212827 C1orf38 0.32 10.61 0.39 2.47e-24 Corneal astigmatism; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03576123 chr11:487126 PTDSS2 -1.23 -18.51 -0.59 1.39e-61 Body mass index; BRCA cis rs6120849 0.754 rs1885116 chr20:33600560 A/G cg24642439 chr20:33292090 TP53INP2 0.59 10.15 0.37 1.51e-22 Protein C levels; BRCA trans rs6952808 0.564 rs55865401 chr7:2145720 G/C cg04565464 chr8:145669602 NFKBIL2 0.38 8.79 0.33 1.41e-17 Bipolar disorder and schizophrenia; BRCA cis rs10501293 0.662 rs4755686 chr11:42999785 A/C cg03447554 chr11:43094025 NA 0.42 8.02 0.3 4.97e-15 Cognitive performance; BRCA cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.43 -0.32 2.33e-16 Bipolar disorder; BRCA cis rs9814567 1.000 rs4334685 chr3:134304335 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg13628971 chr7:2884303 GNA12 0.46 9.21 0.34 4.79e-19 Height; BRCA cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.52 -0.32 1.11e-16 Electroencephalogram traits; BRCA cis rs16958440 0.867 rs12326465 chr18:44678645 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg23711669 chr6:146136114 FBXO30 0.72 16.54 0.55 2.16e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.669 rs10229964 chr7:1051776 A/G cg00431813 chr7:1051703 C7orf50 -0.38 -11.32 -0.41 3.25e-27 Longevity;Endometriosis; BRCA cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 11.14 0.4 1.8e-26 Platelet count; BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -11.28 -0.41 5e-27 Alzheimer's disease; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg24101359 chr6:42928495 GNMT 0.52 11.73 0.42 6.37e-29 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6066835 1.000 rs6095247 chr20:47320835 T/C cg18078177 chr20:47281410 PREX1 0.69 8.04 0.3 4.49e-15 Multiple myeloma; BRCA cis rs8038465 0.592 rs899981 chr15:73935329 G/A cg15420318 chr15:73925796 NPTN 0.45 9.57 0.35 2.32e-20 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg08493051 chr2:3487164 NA -0.43 -9.21 -0.34 4.64e-19 Neurofibrillary tangles; BRCA cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg00071950 chr4:10020882 SLC2A9 0.63 15.51 0.52 2.82e-46 Bone mineral density; BRCA cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Parkinson's disease; BRCA cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg24812749 chr6:127587940 RNF146 -0.77 -15.28 -0.52 3.61e-45 Breast cancer; BRCA cis rs929596 0.563 rs1105879 chr2:234602202 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.37 -9.01 -0.34 2.43e-18 Total bilirubin levels in HIV-1 infection; BRCA cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg24642439 chr20:33292090 TP53INP2 0.72 16.79 0.55 1.12e-52 Coronary artery disease; BRCA cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg12564285 chr5:131593104 PDLIM4 0.32 8.19 0.31 1.38e-15 Blood metabolite levels; BRCA cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg10792982 chr14:105748885 BRF1 0.48 11.26 0.41 5.66e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs8017423 0.569 rs10141476 chr14:90823351 C/T cg04374321 chr14:90722782 PSMC1 -0.49 -11.86 -0.42 1.75e-29 Mortality in heart failure; BRCA cis rs6429082 0.818 rs704714 chr1:235632094 T/C cg26050004 chr1:235667680 B3GALNT2 0.57 13.48 0.47 1.27e-36 Adiposity; BRCA cis rs1401999 0.690 rs6773408 chr3:183716609 G/T cg20387954 chr3:183756860 HTR3D 0.37 8.27 0.31 7.95e-16 Anterior chamber depth; BRCA cis rs2625529 0.668 rs12591313 chr15:72556746 T/C cg16672083 chr15:72433130 SENP8 -0.81 -16.99 -0.56 1.09e-53 Red blood cell count; BRCA trans rs4596713 0.538 rs7865373 chr9:71765105 T/C cg16512924 chr15:28394682 HERC2 0.42 9.98 0.37 6.79e-22 Headache; BRCA cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg22676075 chr6:135203613 NA 0.44 8.54 0.32 9.62e-17 High light scatter reticulocyte percentage of red cells; BRCA cis rs4664304 0.620 rs4665125 chr2:160714314 C/G cg01092293 chr2:160761427 LY75 0.36 8.43 0.32 2.22e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2014572 0.967 rs10426174 chr19:57756055 G/A cg24459738 chr19:57751996 ZNF805 -0.33 -7.98 -0.3 6.73e-15 Hyperactive-impulsive symptoms; BRCA cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg06115741 chr20:33292138 TP53INP2 0.49 11.03 0.4 5.21e-26 Coronary artery disease; BRCA cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg03264133 chr6:25882463 NA 0.49 10.21 0.37 9.25e-23 Intelligence (multi-trait analysis); BRCA cis rs1568889 0.838 rs10835276 chr11:28167147 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.63 0.63 7.09e-73 Bipolar disorder; BRCA cis rs1577917 1.000 rs1995688 chr6:86632319 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.07 -0.43 2.24e-30 Response to antipsychotic treatment; BRCA cis rs7246657 0.722 rs2075284 chr19:38189616 T/C cg18154014 chr19:37997991 ZNF793 -0.5 -9.46 -0.35 5.78e-20 Coronary artery calcification; BRCA cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.08 0.49 2.08e-39 Motion sickness; BRCA trans rs1005277 0.577 rs4934906 chr10:38015028 C/T cg17830980 chr10:43048298 ZNF37B -0.4 -9.14 -0.34 8.34e-19 Extrinsic epigenetic age acceleration; BRCA cis rs4363385 0.720 rs1611755 chr1:152956420 T/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.49 -0.35 4.57e-20 Inflammatory skin disease; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg21280719 chr6:42927975 GNMT -0.32 -13.42 -0.47 2.44e-36 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg01262667 chr19:19385393 TM6SF2 0.41 10.45 0.38 1.08e-23 Tonsillectomy; BRCA cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg26769984 chr7:1090371 C7orf50 -0.46 -8.82 -0.33 1.1e-17 Bronchopulmonary dysplasia; BRCA cis rs57221529 0.766 rs72703042 chr5:579269 C/T cg09021430 chr5:549028 NA -0.68 -14.24 -0.49 3.68e-40 Lung disease severity in cystic fibrosis; BRCA cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg06028605 chr16:24865363 SLC5A11 -0.43 -8.83 -0.33 9.71e-18 Intelligence (multi-trait analysis); BRCA cis rs9682041 0.696 rs13067560 chr3:170094190 G/A cg11886554 chr3:170076028 SKIL 0.51 10.16 0.37 1.41e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs754466 0.561 rs67332822 chr10:79706118 G/A cg17075019 chr10:79541650 NA -0.54 -7.96 -0.3 7.75e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9814567 1.000 rs7426847 chr3:134267519 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.29 0.34 2.47e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6598955 0.671 rs10159433 chr1:26618370 A/G cg04990556 chr1:26633338 UBXN11 0.55 9.12 0.34 9.99e-19 Obesity-related traits; BRCA trans rs9291683 0.645 rs11557743 chr4:10118377 C/G cg26043149 chr18:55253948 FECH -0.41 -9.11 -0.34 1.08e-18 Bone mineral density; BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.72 0.42 6.85e-29 Tonsillectomy; BRCA cis rs7829975 0.617 rs4841072 chr8:8791253 C/A cg15556689 chr8:8085844 FLJ10661 -0.43 -11.93 -0.43 8.84e-30 Mood instability; BRCA cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg19077165 chr18:44547161 KATNAL2 0.63 14.1 0.49 1.64e-39 Personality dimensions; BRCA cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg26384229 chr12:38710491 ALG10B 0.85 22.84 0.67 7.26e-85 Heart rate; BRCA cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg24812749 chr6:127587940 RNF146 0.87 20.52 0.63 2.92e-72 Breast cancer; BRCA cis rs17604090 1.000 rs28420551 chr7:29685353 G/A cg19413766 chr7:29689036 LOC646762 -0.51 -7.99 -0.3 6.22e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.68 -13.27 -0.46 1.14e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4588572 0.643 rs7700390 chr5:77789532 T/C cg11547950 chr5:77652471 NA -0.5 -8.93 -0.33 4.39e-18 Triglycerides; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 20.81 0.64 8.17e-74 Platelet count; BRCA cis rs1568889 1.000 rs66702115 chr11:28181703 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.84 0.51 5.15e-43 Bipolar disorder; BRCA trans rs208520 0.690 rs851468 chr6:66825875 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.46 -0.63 6.47e-72 Exhaled nitric oxide output; BRCA trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg22491629 chr6:157744540 C6orf35 -0.65 -11.64 -0.42 1.62e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.26 -0.31 8.61e-16 Bipolar disorder; BRCA cis rs6977660 0.652 rs10267417 chr7:19843797 C/T cg07541023 chr7:19748670 TWISTNB 0.55 9.19 0.34 5.31e-19 Thyroid stimulating hormone; BRCA cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.41 -8.97 -0.33 3.31e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg12573674 chr2:1569213 NA -0.58 -12.54 -0.44 2.11e-32 IgG glycosylation; BRCA cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg08085267 chr17:45401833 C17orf57 -0.58 -11.98 -0.43 5.85e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9309473 0.687 rs7576824 chr2:73611281 C/T cg20560298 chr2:73613845 ALMS1 0.51 13.99 0.48 5.68e-39 Metabolite levels; BRCA cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg00071950 chr4:10020882 SLC2A9 0.62 14.77 0.5 1.08e-42 Bone mineral density; BRCA cis rs7666738 0.830 rs13147195 chr4:98893334 G/T cg05340658 chr4:99064831 C4orf37 0.61 14.54 0.5 1.37e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs6594499 0.872 rs10038177 chr5:110436450 C/T cg04022379 chr5:110408740 TSLP 0.35 8.0 0.3 5.7e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg11814155 chr7:99998594 ZCWPW1 0.48 8.59 0.32 6.58e-17 Platelet count; BRCA trans rs6582630 0.519 rs10880629 chr12:38533611 T/G cg06521331 chr12:34319734 NA -0.47 -8.79 -0.33 1.32e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs10465746 0.967 rs12120160 chr1:84342835 T/G cg10977910 chr1:84465055 TTLL7 0.51 10.28 0.38 4.89e-23 Obesity-related traits; BRCA trans rs7980799 0.653 rs1384598 chr12:33622899 T/A cg26384229 chr12:38710491 ALG10B -0.49 -10.57 -0.39 3.57e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg17971929 chr21:40555470 PSMG1 -0.47 -10.19 -0.37 1.03e-22 Menarche (age at onset); BRCA cis rs514406 0.929 rs557847 chr1:53333116 A/G cg16325326 chr1:53192061 ZYG11B 0.7 16.94 0.56 1.91e-53 Monocyte count; BRCA cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg03060546 chr3:49711283 APEH 0.58 9.49 0.35 4.62e-20 Menarche (age at onset); BRCA cis rs965469 0.948 rs6051769 chr20:3326438 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -9.86 -0.36 1.86e-21 IFN-related cytopenia; BRCA cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Bladder cancer; BRCA cis rs6878727 0.665 rs256851 chr5:123662677 T/C cg01806427 chr5:123737813 NA -0.36 -8.07 -0.3 3.5e-15 Breast cancer; BRCA cis rs9828933 0.577 rs704374 chr3:63865947 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.83 14.3 0.49 1.96e-40 Type 2 diabetes; BRCA cis rs2832077 0.506 rs10222093 chr21:30163518 T/C cg08807101 chr21:30365312 RNF160 -0.4 -8.16 -0.31 1.79e-15 Cognitive test performance; BRCA cis rs4319547 0.695 rs6488958 chr12:122880704 A/G cg05707623 chr12:122985044 ZCCHC8 -0.47 -9.32 -0.35 1.93e-19 Body mass index; BRCA cis rs12618769 0.597 rs72821908 chr2:99085359 A/G cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs6120849 0.754 rs1885117 chr20:33600740 C/T cg24642439 chr20:33292090 TP53INP2 0.59 10.15 0.37 1.51e-22 Protein C levels; BRCA cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg06552810 chr11:31128660 NA -0.39 -8.81 -0.33 1.18e-17 Red blood cell count; BRCA cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg25173405 chr17:45401733 C17orf57 0.51 11.12 0.4 2.23e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7555523 0.830 rs6660601 chr1:165695855 C/T cg24409356 chr1:165738333 TMCO1 0.5 7.93 0.3 9.48e-15 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA trans rs9784649 0.760 rs72755820 chr5:25066181 G/A cg11038491 chr20:34638489 LOC647979 -0.47 -8.73 -0.33 2.19e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg13319975 chr6:146136371 FBXO30 0.42 9.84 0.36 2.32e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg06115741 chr20:33292138 TP53INP2 -0.37 -8.15 -0.31 1.9e-15 Glomerular filtration rate (creatinine); BRCA cis rs2760061 0.626 rs596675 chr1:228117892 G/A cg02753203 chr1:228287806 NA -0.6 -12.82 -0.45 1.18e-33 Diastolic blood pressure; BRCA cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 14.17 0.49 7.92e-40 Colorectal cancer; BRCA cis rs1003719 0.788 rs3787783 chr21:38462959 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg09033563 chr22:24373618 LOC391322 -0.38 -7.84 -0.3 1.88e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg25237894 chr2:233734115 C2orf82 -0.4 -11.7 -0.42 8.58e-29 Coronary artery disease; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.85 -0.3 1.74e-14 Total body bone mineral density; BRCA cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg12219531 chr12:120966889 COQ5 0.54 11.32 0.41 3.35e-27 High light scatter reticulocyte count; BRCA cis rs4722585 0.533 rs757371 chr7:26199207 A/G cg07876897 chr7:26191696 NFE2L3 0.41 8.94 0.33 4.1e-18 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA trans rs4819388 0.693 rs4818889 chr21:45645308 A/G cg17383793 chr5:52405638 MOCS2 0.48 10.75 0.39 6.56e-25 Celiac disease; BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg27170947 chr2:26402098 FAM59B -0.79 -12.76 -0.45 2.12e-33 Gut microbiome composition (summer); BRCA cis rs17376456 0.877 rs12374470 chr5:93481046 A/G cg25358565 chr5:93447407 FAM172A 1.23 19.31 0.61 9.12e-66 Diabetic retinopathy; BRCA cis rs9287719 0.967 rs6432121 chr2:10753804 G/C cg00105475 chr2:10696890 NA 0.44 10.26 0.38 5.62e-23 Prostate cancer; BRCA cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.42 -12.0 -0.43 4.43e-30 Monocyte percentage of white cells; BRCA cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg18514922 chr2:160761262 LY75 -0.36 -8.45 -0.32 1.99e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9837602 1.000 rs9878931 chr3:99712634 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.28 0.41 4.85e-27 Breast cancer; BRCA cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg15352829 chr14:105391018 PLD4 0.37 12.14 0.43 1.17e-30 Rheumatoid arthritis; BRCA cis rs1506636 0.962 rs10273985 chr7:123309538 A/T cg03229431 chr7:123269106 ASB15 -0.63 -14.15 -0.49 9.48e-40 Plateletcrit;Platelet count; BRCA trans rs4689592 0.619 rs3796908 chr4:7061378 G/A cg07817883 chr1:32538562 TMEM39B -0.44 -8.08 -0.3 3.22e-15 Monocyte percentage of white cells; BRCA cis rs4803468 0.934 rs2317131 chr19:41885151 C/T cg09537434 chr19:41945824 ATP5SL -0.96 -23.36 -0.68 9.73e-88 Height; BRCA cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg19717773 chr7:2847554 GNA12 -0.41 -9.34 -0.35 1.52e-19 Height; BRCA cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg12927641 chr6:109611667 NA -0.42 -11.0 -0.4 6.83e-26 Reticulocyte fraction of red cells; BRCA cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.48e-66 Mean platelet volume; BRCA trans rs11098499 0.818 rs7688802 chr4:120451668 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg16102102 chr5:83017553 HAPLN1 -0.86 -16.29 -0.54 3.74e-50 Prostate cancer; BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg05863683 chr7:1912471 MAD1L1 0.42 8.82 0.33 1.11e-17 Bipolar disorder and schizophrenia; BRCA cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg22800045 chr5:56110881 MAP3K1 -0.51 -10.11 -0.37 2.2e-22 Type 2 diabetes; BRCA cis rs875971 0.800 rs427557 chr7:65519250 A/G cg11764359 chr7:65958608 NA 0.76 17.67 0.57 3.46e-57 Aortic root size; BRCA cis rs35110281 0.667 rs4819293 chr21:45125863 A/G cg21573476 chr21:45109991 RRP1B -0.44 -10.87 -0.39 2.34e-25 Mean corpuscular volume; BRCA cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.15 -17.53 -0.57 1.79e-56 Hemostatic factors and hematological phenotypes; BRCA cis rs2880765 0.631 rs55767890 chr15:86004142 C/G cg19183879 chr15:85880815 NA -0.33 -8.03 -0.3 4.84e-15 Coronary artery disease; BRCA cis rs10911251 0.508 rs2245784 chr1:183107665 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.46 0.55 5.2e-51 Colorectal cancer; BRCA cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.75 -20.21 -0.62 1.29e-70 Chronic sinus infection; BRCA cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg08975724 chr8:8085496 FLJ10661 0.47 9.97 0.37 7.55e-22 Mood instability; BRCA cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg23033748 chr14:75592666 NEK9 0.45 10.58 0.39 3.38e-24 Height; BRCA cis rs6450176 0.951 rs255757 chr5:53309371 G/A ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.16 -0.51 1.42e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs514406 0.792 rs481440 chr1:53344976 C/T cg01802117 chr1:53393560 SCP2 -0.42 -9.6 -0.36 1.73e-20 Monocyte count; BRCA cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.3 -0.31 5.98e-16 IgG glycosylation; BRCA cis rs16866061 0.515 rs1027340 chr2:225370554 C/A cg22455342 chr2:225449267 CUL3 0.34 9.15 0.34 7.34e-19 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA trans rs11098499 0.909 rs2127821 chr4:120394535 T/C cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.23e-34 Corneal astigmatism; BRCA cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg27347728 chr4:17578864 LAP3 -0.45 -8.79 -0.33 1.38e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2387326 0.717 rs12266400 chr10:129944536 C/G cg16087940 chr10:129947807 NA 0.46 8.35 0.31 4.12e-16 Select biomarker traits; BRCA cis rs561341 0.769 rs7217004 chr17:30178092 A/G cg23018236 chr17:30244563 NA 0.61 8.75 0.33 1.95e-17 Hip circumference adjusted for BMI; BRCA cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg18016565 chr1:150552671 MCL1 0.35 8.36 0.31 3.93e-16 Tonsillectomy; BRCA cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.48 10.49 0.38 7.63e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg11752832 chr7:134001865 SLC35B4 -0.44 -11.1 -0.4 2.59e-26 Mean platelet volume; BRCA cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg23583168 chr7:148888333 NA -0.86 -20.09 -0.62 5.61e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg18305652 chr10:134549665 INPP5A 0.49 11.02 0.4 5.83e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs12310956 0.532 rs1852226 chr12:33962940 G/A cg26384229 chr12:38710491 ALG10B 0.48 10.64 0.39 1.96e-24 Morning vs. evening chronotype; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg00166722 chr3:10149974 C3orf24 0.64 12.73 0.45 3.13e-33 Alzheimer's disease; BRCA cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg14019146 chr3:50243930 SLC38A3 -0.4 -9.84 -0.36 2.21e-21 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -8.96 -0.33 3.42e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4812048 0.649 rs3761258 chr20:57618596 C/G cg14073986 chr20:57617431 SLMO2 -0.76 -11.59 -0.42 2.61e-28 Mean platelet volume; BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg22920501 chr2:26401640 FAM59B -0.67 -11.56 -0.42 3.5e-28 Gut microbiome composition (summer); BRCA cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg02503808 chr4:7069936 GRPEL1 0.76 17.42 0.57 6.83e-56 Monocyte percentage of white cells; BRCA cis rs889312 0.500 rs702688 chr5:56190986 A/G cg18230493 chr5:56204884 C5orf35 -0.39 -8.1 -0.31 2.76e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg23029597 chr12:123009494 RSRC2 -0.57 -11.43 -0.41 1.16e-27 Body mass index; BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg22920501 chr2:26401640 FAM59B -0.63 -11.34 -0.41 2.85e-27 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs7301826 0.651 rs34749116 chr12:131280752 G/A cg11011512 chr12:131303247 STX2 -0.46 -11.26 -0.41 5.78e-27 Plasma plasminogen activator levels; BRCA cis rs9467711 0.606 rs9348726 chr6:26605206 G/A cg12826209 chr6:26865740 GUSBL1 0.63 8.27 0.31 7.95e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg06784218 chr1:46089804 CCDC17 0.44 10.63 0.39 2.06e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg19077165 chr18:44547161 KATNAL2 0.58 12.68 0.45 5.24e-33 Personality dimensions; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.58 -0.32 7.19e-17 Total body bone mineral density; BRCA cis rs3771570 1.000 rs1984598 chr2:242284824 G/A cg21155796 chr2:242212141 HDLBP 0.48 8.36 0.31 3.97e-16 Prostate cancer; BRCA cis rs6963495 0.818 rs73190183 chr7:105163022 G/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7301826 0.651 rs10744485 chr12:131298550 A/G cg11011512 chr12:131303247 STX2 0.5 13.03 0.46 1.42e-34 Plasma plasminogen activator levels; BRCA cis rs7937682 0.961 rs11601674 chr11:111634354 C/T cg09085632 chr11:111637200 PPP2R1B -1.02 -24.09 -0.69 1.01e-91 Primary sclerosing cholangitis; BRCA cis rs2637030 0.559 rs923609 chr5:52912249 G/A cg06476337 chr5:52856530 NDUFS4 0.38 8.55 0.32 9.09e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg15017067 chr4:17643749 FAM184B -0.33 -10.18 -0.37 1.21e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.6 11.84 0.42 2.17e-29 Multiple sclerosis; BRCA cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg05347473 chr6:146136440 FBXO30 0.41 8.21 0.31 1.26e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3862030 0.720 rs11593583 chr10:104228149 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 12.04 0.43 3.05e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs514406 0.679 rs545719 chr1:53304922 T/C cg24675658 chr1:53192096 ZYG11B -0.71 -16.09 -0.54 3.88e-49 Monocyte count; BRCA cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 8.84 0.33 8.93e-18 Bipolar disorder; BRCA cis rs727479 0.543 rs8023263 chr15:51517597 G/T cg19946085 chr15:51559439 CYP19A1 -0.28 -7.94 -0.3 8.94e-15 Estradiol levels; BRCA cis rs7590720 1.000 rs6435930 chr2:216885852 A/G cg12620499 chr2:216877984 MREG 0.8 22.15 0.66 4.35e-81 Alcohol dependence; BRCA cis rs1580019 0.961 rs1868776 chr7:32494435 G/T cg07520158 chr7:32535189 LSM5;AVL9 -0.38 -8.42 -0.32 2.47e-16 Cognitive ability; BRCA cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg21573476 chr21:45109991 RRP1B -0.33 -8.39 -0.31 3.21e-16 Mean corpuscular volume; BRCA cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg24130564 chr14:104152367 KLC1 0.36 8.2 0.31 1.33e-15 Intelligence (multi-trait analysis); BRCA cis rs929354 1.000 rs1182452 chr7:157053618 G/A cg17757837 chr7:157058334 UBE3C -0.71 -17.58 -0.57 9.48e-57 Body mass index; BRCA cis rs853679 0.517 rs9393891 chr6:28079160 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA trans rs526821 0.532 rs578067 chr11:55313690 T/G cg11707556 chr5:10655725 ANKRD33B -0.36 -8.11 -0.31 2.54e-15 Pediatric bone mineral density (spine); BRCA cis rs9300255 0.537 rs10772993 chr12:123644714 A/G cg00376283 chr12:123451042 ABCB9 0.51 11.15 0.4 1.63e-26 Neutrophil percentage of white cells; BRCA cis rs4919694 1.000 rs78893207 chr10:104796138 T/C cg04362960 chr10:104952993 NT5C2 0.94 14.5 0.5 2.26e-41 Arsenic metabolism; BRCA cis rs7677751 0.806 rs7673853 chr4:55096606 T/C cg17187183 chr4:55093834 PDGFRA 0.44 9.27 0.34 2.73e-19 Corneal astigmatism; BRCA cis rs939658 1.000 rs8031504 chr15:79458589 G/T cg17916960 chr15:79447300 NA 0.39 9.85 0.36 2.09e-21 Refractive error; BRCA cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg14019146 chr3:50243930 SLC38A3 -0.42 -10.11 -0.37 2.11e-22 Body mass index; BRCA cis rs9329289 0.510 rs28579610 chr10:2546080 C/A cg15501526 chr10:2543763 NA 0.46 10.73 0.39 8.45e-25 Age-related hearing impairment; BRCA trans rs57221529 0.766 rs72703064 chr5:587825 T/C cg25482853 chr8:67687455 SGK3 1.02 16.08 0.54 4.27e-49 Lung disease severity in cystic fibrosis; BRCA cis rs3617 0.573 rs9850563 chr3:52912214 G/A cg11645453 chr3:52864694 ITIH4 -0.37 -9.52 -0.35 3.58e-20 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs17092148 1.000 rs3787220 chr20:33337751 T/C cg16810054 chr20:33298113 TP53INP2 -0.5 -11.3 -0.41 3.92e-27 Neuroticism; BRCA cis rs2625529 0.590 rs3803471 chr15:72500786 A/G cg16672083 chr15:72433130 SENP8 -0.83 -17.39 -0.57 1.01e-55 Red blood cell count; BRCA cis rs4478858 0.735 rs7547897 chr1:31797593 G/A cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg17892150 chr10:133769511 PPP2R2D 0.72 15.77 0.53 1.51e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9816226 1.000 rs61587156 chr3:185831583 T/G cg00760338 chr3:185826511 ETV5 -0.52 -8.06 -0.3 3.64e-15 Obesity;Body mass index; BRCA cis rs965469 0.817 rs6515806 chr20:3359138 A/G cg25506879 chr20:3388711 C20orf194 -0.47 -9.42 -0.35 7.83e-20 IFN-related cytopenia; BRCA cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg05283184 chr6:79620031 NA -0.43 -11.41 -0.41 1.41e-27 Intelligence (multi-trait analysis); BRCA trans rs9409565 0.826 rs639276 chr9:97206737 G/T cg05679027 chr9:99775184 HIATL2 -0.43 -9.44 -0.35 6.67e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.35 0.35 1.45e-19 Parkinson's disease; BRCA cis rs9287719 0.649 rs10929685 chr2:10732799 T/C cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 12.09 0.43 1.99e-30 Personality dimensions; BRCA cis rs28374715 0.578 rs10518717 chr15:41623368 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -23.43 -0.68 4.26e-88 Ulcerative colitis; BRCA cis rs12210905 0.688 rs72839474 chr6:27324757 T/C cg08851530 chr6:28072375 NA 0.91 8.7 0.33 2.7e-17 Hip circumference adjusted for BMI; BRCA cis rs2070488 0.804 rs13092164 chr3:38458533 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.01 0.56 8.37e-54 Electrocardiographic conduction measures; BRCA cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg24642439 chr20:33292090 TP53INP2 0.56 12.01 0.43 4.3e-30 Coronary artery disease; BRCA cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg21395723 chr22:39101663 GTPBP1 0.4 8.65 0.32 4.14e-17 Menopause (age at onset); BRCA trans rs3960554 0.808 rs79864016 chr7:75655838 A/G cg19862616 chr7:65841803 NCRNA00174 0.6 12.48 0.44 3.72e-32 Eotaxin levels; BRCA cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.4 -0.41 1.63e-27 Electroencephalogram traits; BRCA cis rs12541635 0.902 rs59123253 chr8:107006365 C/T cg10147462 chr8:107024639 NA 0.37 9.97 0.37 7.11e-22 Age of smoking initiation; BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26314531 chr2:26401878 FAM59B -0.78 -12.62 -0.45 8.84e-33 Gut microbiome composition (summer); BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg27071517 chr21:31768726 KRTAP13-1 0.29 7.86 0.3 1.66e-14 HDL cholesterol; BRCA cis rs7945718 0.967 rs11022491 chr11:12777620 A/G cg25843174 chr11:12811716 TEAD1 -0.23 -8.66 -0.32 3.77e-17 Educational attainment (years of education); BRCA cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.3 -0.31 6.01e-16 Electroencephalogram traits; BRCA cis rs4363385 0.818 rs436621 chr1:153005492 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg03060546 chr3:49711283 APEH 0.6 10.31 0.38 3.76e-23 Menarche (age at onset); BRCA trans rs877282 0.898 rs11253338 chr10:759559 C/T cg22713356 chr15:30763199 NA 1.2 21.44 0.65 3.04e-77 Uric acid levels; BRCA cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.04 -0.54 6.86e-49 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs17401966 1.000 rs11576866 chr1:10414432 A/G cg15208524 chr1:10270712 KIF1B 0.38 7.91 0.3 1.12e-14 Hepatocellular carcinoma; BRCA cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg06784218 chr1:46089804 CCDC17 -0.54 -13.22 -0.46 1.85e-35 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2415984 0.622 rs12435397 chr14:46940867 G/A cg14871534 chr14:47121158 RPL10L -0.32 -7.87 -0.3 1.54e-14 Number of children ever born; BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg14820908 chr5:178986412 RUFY1 0.48 11.48 0.41 7.07e-28 Lung cancer; BRCA trans rs11098499 0.863 rs1010739 chr4:120463471 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.15 0.31 1.94e-15 Corneal astigmatism; BRCA cis rs2904967 0.810 rs507005 chr11:65045615 T/C cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg21644426 chr2:191273491 MFSD6 0.44 11.23 0.41 7.76e-27 Pulse pressure; BRCA cis rs477692 0.699 rs471390 chr10:131382825 A/G cg05714579 chr10:131428358 MGMT -0.47 -10.43 -0.38 1.21e-23 Response to temozolomide; BRCA cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.53 -10.04 -0.37 4.13e-22 Aortic root size; BRCA cis rs6582630 0.502 rs7312212 chr12:38274760 T/G cg13010199 chr12:38710504 ALG10B 0.41 8.52 0.32 1.14e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg18016565 chr1:150552671 MCL1 -0.37 -8.61 -0.32 5.55e-17 Tonsillectomy; BRCA cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22496380 chr5:211416 CCDC127 -1.01 -14.34 -0.49 1.21e-40 Breast cancer; BRCA cis rs7729447 0.776 rs58529247 chr5:32693889 C/T cg16267343 chr5:32710456 NPR3 0.41 8.27 0.31 7.85e-16 Blood pressure; BRCA cis rs495337 0.735 rs2281217 chr20:48568055 C/G cg17835207 chr20:48524531 SPATA2 -0.67 -16.31 -0.54 2.93e-50 Psoriasis; BRCA cis rs17641971 0.684 rs4873095 chr8:49990166 A/T cg00325661 chr8:49890786 NA 0.39 10.81 0.39 4.14e-25 Blood metabolite levels; BRCA cis rs12413816 0.818 rs35567671 chr10:13769722 C/A cg16485048 chr10:13749193 FRMD4A 0.57 12.73 0.45 2.92e-33 Red cell distribution width; BRCA cis rs7267979 0.932 rs6115215 chr20:25562500 C/T cg08601574 chr20:25228251 PYGB 0.36 8.43 0.32 2.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.18 0.49 7.18e-40 Motion sickness; BRCA cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg11764359 chr7:65958608 NA 0.73 16.22 0.54 8.75e-50 Aortic root size; BRCA cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.48 0.52 3.93e-46 Colorectal cancer; BRCA cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.8 -0.33 1.24e-17 Aortic root size; BRCA cis rs10899021 1.000 rs7102084 chr11:74358132 T/C cg25880958 chr11:74394337 NA -0.5 -7.89 -0.3 1.27e-14 Response to metformin (IC50); BRCA cis rs8028313 0.630 rs16951105 chr15:67965694 A/G cg24579218 chr15:68104479 NA -0.35 -7.82 -0.3 2.19e-14 Obesity; BRCA trans rs12517041 1.000 rs1366454 chr5:23319172 G/C ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.73 0.57 1.62e-57 Colonoscopy-negative controls vs population controls; BRCA cis rs7633770 0.710 rs11710586 chr3:46693457 A/G cg11219411 chr3:46661640 NA -0.51 -12.19 -0.43 7.14e-31 Coronary artery disease; BRCA cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg26408565 chr15:76604113 ETFA -0.47 -9.93 -0.37 1.05e-21 Blood metabolite levels; BRCA cis rs3916 0.955 rs12828810 chr12:121152017 T/G cg21892295 chr12:121157589 UNC119B -0.38 -9.74 -0.36 5.55e-21 Urinary metabolites (H-NMR features); BRCA cis rs2637266 0.935 rs12259550 chr10:78352843 A/G cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.29e-14 Pulmonary function; BRCA cis rs7809950 0.815 rs62482495 chr7:106965009 A/G cg23024343 chr7:107201750 COG5 -0.47 -9.55 -0.35 2.67e-20 Coronary artery disease; BRCA cis rs7119 0.717 rs11632729 chr15:77722006 G/A cg17802220 chr15:77601643 NA -0.44 -10.26 -0.38 5.62e-23 Type 2 diabetes; BRCA cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.35e-15 Extrinsic epigenetic age acceleration; BRCA cis rs2387326 0.717 rs11016102 chr10:129945154 A/G cg16087940 chr10:129947807 NA -0.45 -8.08 -0.3 3.15e-15 Select biomarker traits; BRCA cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg09184832 chr6:79620586 NA -0.52 -11.36 -0.41 2.21e-27 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg22907277 chr7:1156413 C7orf50 0.5 11.01 0.4 6.34e-26 Longevity;Endometriosis; BRCA cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg02297831 chr4:17616191 MED28 0.37 8.58 0.32 7.18e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17467752 chr17:38218738 THRA 0.44 10.08 0.37 2.91e-22 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); BRCA cis rs17376456 0.877 rs12153506 chr5:93360953 T/G cg25358565 chr5:93447407 FAM172A 1.14 18.59 0.59 5.23e-62 Diabetic retinopathy; BRCA cis rs698833 0.828 rs6745281 chr2:44534472 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.24 0.38 6.63e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9790314 0.663 rs12639128 chr3:160639645 A/G cg03342759 chr3:160939853 NMD3 0.44 8.83 0.33 1.04e-17 Morning vs. evening chronotype; BRCA cis rs7246657 0.653 rs10406612 chr19:37716611 C/T cg18154014 chr19:37997991 ZNF793 0.56 9.22 0.34 4.37e-19 Coronary artery calcification; BRCA cis rs490234 0.588 rs34983978 chr9:128169170 G/A cg14078157 chr9:128172775 NA -0.55 -12.03 -0.43 3.3e-30 Mean arterial pressure; BRCA cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg26446133 chr18:72167187 CNDP2 -0.8 -20.6 -0.63 1.1e-72 Refractive error; BRCA cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg11301795 chr4:187892539 NA -0.3 -10.15 -0.37 1.54e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs2439831 0.850 rs8042868 chr15:43939642 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.77 13.32 0.47 6.5e-36 Lung cancer in ever smokers; BRCA cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.34 -7.86 -0.3 1.68e-14 High light scatter reticulocyte count; BRCA cis rs2882667 0.620 rs3789151 chr5:138145460 C/T cg04439458 chr5:138467593 SIL1 0.31 7.86 0.3 1.62e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7103648 0.695 rs10838726 chr11:47568344 C/G cg20307385 chr11:47447363 PSMC3 0.8 19.14 0.6 6.89e-65 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs3125734 0.633 rs12217669 chr10:63988456 A/G cg19640130 chr10:64028056 RTKN2 0.29 8.2 0.31 1.3e-15 Rheumatoid arthritis; BRCA cis rs6542838 0.641 rs7565510 chr2:99494833 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.39 -8.84 -0.33 9.53e-18 Fear of minor pain; BRCA cis rs1691799 0.867 rs1168338 chr12:66759369 T/C cg16791601 chr12:66731901 HELB -0.67 -18.36 -0.59 8.64e-61 White blood cell count (basophil); BRCA cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg15556689 chr8:8085844 FLJ10661 -0.4 -11.32 -0.41 3.34e-27 Mood instability; BRCA cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg26384229 chr12:38710491 ALG10B -0.62 -14.81 -0.51 7.42e-43 Bladder cancer; BRCA cis rs738322 0.577 rs6001034 chr22:38558459 A/G cg25457927 chr22:38595422 NA -0.35 -12.63 -0.45 8.21e-33 Cutaneous nevi; BRCA cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg08754478 chr10:133766260 PPP2R2D -0.69 -14.12 -0.49 1.38e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg03433033 chr1:76189801 ACADM 0.7 12.91 0.45 4.96e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg18200150 chr17:30822561 MYO1D 0.34 8.74 0.33 2.08e-17 Schizophrenia; BRCA cis rs1215050 0.791 rs260890 chr4:98741698 A/G cg05340658 chr4:99064831 C4orf37 0.45 10.64 0.39 1.9e-24 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -8.84 -0.33 9.42e-18 Alzheimer's disease (late onset); BRCA cis rs6582630 0.555 rs35186318 chr12:38295822 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.05 -0.37 3.53e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.23 -0.41 7.67e-27 Lymphocyte counts; BRCA cis rs921968 0.565 rs7605055 chr2:219627050 G/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 6.22e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs6977660 1.000 rs12672557 chr7:19804237 G/A cg05791153 chr7:19748676 TWISTNB 0.47 9.03 0.34 1.95e-18 Thyroid stimulating hormone; BRCA cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg06115741 chr20:33292138 TP53INP2 0.39 8.55 0.32 9.35e-17 Coronary artery disease; BRCA cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg23583168 chr7:148888333 NA -0.81 -18.33 -0.59 1.28e-60 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17270561 0.609 rs9348692 chr6:25720812 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.97e-18 Iron status biomarkers; BRCA cis rs4073582 0.595 rs801739 chr11:65922589 A/G cg16950941 chr11:66035639 RAB1B 0.42 11.26 0.41 6.05e-27 Gout; BRCA cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg06115741 chr20:33292138 TP53INP2 0.38 8.46 0.32 1.86e-16 Glomerular filtration rate (creatinine); BRCA cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs858239 0.602 rs6953996 chr7:23175946 A/G cg23682824 chr7:23144976 KLHL7 0.4 10.48 0.38 7.88e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.6e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9296092 0.538 rs9461882 chr6:33520221 A/C cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9467160 0.651 rs9393558 chr6:24454196 G/T cg20631270 chr6:24437470 GPLD1 0.43 8.69 0.32 3.16e-17 Liver enzyme levels; BRCA cis rs7927592 0.913 rs11228276 chr11:68307525 A/G cg20283391 chr11:68216788 NA -0.46 -9.02 -0.34 2.24e-18 Total body bone mineral density; BRCA cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.82 -0.42 2.58e-29 Bipolar disorder; BRCA cis rs10740039 0.768 rs920646 chr10:62463525 C/T cg02922035 chr10:62493342 NA 0.41 7.81 0.3 2.37e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg14983838 chr19:29218262 NA 0.54 10.09 0.37 2.65e-22 Methadone dose in opioid dependence; BRCA cis rs12348691 0.503 rs7849497 chr9:100615660 G/C cg13688889 chr9:100608707 NA -0.49 -9.9 -0.36 1.32e-21 Alopecia areata; BRCA trans rs208520 0.802 rs208496 chr6:66930786 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.36 -0.54 1.71e-50 Exhaled nitric oxide output; BRCA cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg18132916 chr6:79620363 NA -0.49 -11.19 -0.4 1.1e-26 Intelligence (multi-trait analysis); BRCA cis rs9986765 0.867 rs1994498 chr7:142816448 C/T cg21852589 chr7:142981689 TMEM139 0.57 9.72 0.36 6.17e-21 Cancer;Dermatomyositis; BRCA cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg09469691 chr10:81107165 PPIF 0.42 9.29 0.34 2.42e-19 Height; BRCA cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg16586182 chr3:47516702 SCAP -0.55 -12.36 -0.44 1.3e-31 Colorectal cancer; BRCA cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg08885076 chr2:99613938 TSGA10 -0.52 -10.28 -0.38 4.9e-23 Chronic sinus infection; BRCA cis rs12210905 0.688 rs12196452 chr6:27344415 A/T cg08851530 chr6:28072375 NA 0.91 8.7 0.33 2.7e-17 Hip circumference adjusted for BMI; BRCA cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg11266682 chr4:10021025 SLC2A9 0.49 13.12 0.46 5.22e-35 Bone mineral density; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg16590910 chr6:42928470 GNMT 0.42 9.22 0.34 4.38e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2070488 0.965 rs7372386 chr3:38484175 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 19.57 0.61 3.41e-67 Electrocardiographic conduction measures; BRCA cis rs1005277 0.505 rs200937 chr10:38135772 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -16.16 -0.54 1.65e-49 Extrinsic epigenetic age acceleration; BRCA cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11890956 chr21:40555474 PSMG1 -0.68 -16.65 -0.55 5.63e-52 Cognitive function; BRCA cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg18446336 chr7:2847575 GNA12 -0.41 -10.28 -0.38 4.86e-23 Height; BRCA cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.8e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg12751644 chr20:60527061 NA -0.33 -7.87 -0.3 1.57e-14 Body mass index; BRCA cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg01849466 chr14:104193079 ZFYVE21 0.46 10.54 0.38 4.59e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs1003719 0.788 rs2835582 chr21:38458773 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.05 0.49 2.98e-39 Eye color traits; BRCA cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg25358565 chr5:93447407 FAM172A 1.17 17.98 0.58 8.92e-59 Diabetic retinopathy; BRCA cis rs250677 0.687 rs36046 chr5:148441257 A/C cg12140854 chr5:148520817 ABLIM3 -0.41 -8.71 -0.33 2.59e-17 Breast cancer; BRCA trans rs62103177 0.608 rs34383580 chr18:77833263 A/G cg05926928 chr17:57297772 GDPD1 -0.76 -10.74 -0.39 7.22e-25 Opioid sensitivity; BRCA cis rs3772130 0.583 rs4296627 chr3:121567684 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.27 0.49 2.71e-40 Cognitive performance; BRCA cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.87 -0.33 7.43e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg13010199 chr12:38710504 ALG10B -0.4 -8.59 -0.32 6.42e-17 Bladder cancer; BRCA trans rs6582630 0.537 rs7310749 chr12:38400472 C/T cg06521331 chr12:34319734 NA -0.47 -8.6 -0.32 6.19e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg13271783 chr10:134563150 INPP5A -0.46 -9.59 -0.35 1.97e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.55 0.57 1.47e-56 Bladder cancer; BRCA cis rs2425143 1.000 rs11696947 chr20:34312658 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.38 0.38 2.02e-23 Motion sickness; BRCA cis rs2346177 0.875 rs12986585 chr2:46644121 T/A cg02822958 chr2:46747628 ATP6V1E2 0.41 8.49 0.32 1.49e-16 HDL cholesterol; BRCA cis rs6545883 0.929 rs3732170 chr2:61749716 C/T cg15711740 chr2:61764176 XPO1 -0.55 -14.18 -0.49 7.07e-40 Tuberculosis; BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.92 -0.3 1.05e-14 Total body bone mineral density; BRCA cis rs13136331 0.684 rs13123354 chr4:88729912 C/T cg22416721 chr4:88570574 DMP1 0.38 8.08 0.3 3.28e-15 Sitting height ratio; BRCA cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11644478 chr21:40555479 PSMG1 0.73 14.23 0.49 4.17e-40 Cognitive function; BRCA cis rs6484504 0.625 rs7112412 chr11:31370271 T/C cg14844989 chr11:31128820 NA 0.44 9.7 0.36 7.83e-21 Red blood cell count; BRCA cis rs17401966 0.518 rs10864453 chr1:10407169 T/G cg03954927 chr1:10346856 KIF1B 0.34 10.32 0.38 3.51e-23 Hepatocellular carcinoma; BRCA cis rs17401966 0.931 rs1002076 chr1:10438892 G/A cg03954927 chr1:10346856 KIF1B 0.48 14.83 0.51 5.68e-43 Hepatocellular carcinoma; BRCA cis rs10463316 0.894 rs4099169 chr5:150766526 C/T cg03212797 chr5:150827313 SLC36A1 -0.41 -8.13 -0.31 2.23e-15 Metabolite levels (Pyroglutamine); BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg11062466 chr8:58055876 NA 0.54 9.12 0.34 9.92e-19 Developmental language disorder (linguistic errors); BRCA cis rs881375 0.678 rs2416804 chr9:123676396 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.49 -10.06 -0.37 3.27e-22 Rheumatoid arthritis; BRCA trans rs2832077 0.943 rs2832097 chr21:30173340 A/T cg14791747 chr16:20752902 THUMPD1 -0.4 -9.82 -0.36 2.75e-21 Cognitive test performance; BRCA trans rs6964833 1.000 rs36044436 chr7:74089819 G/C cg07504079 chr7:72649617 NCF1B -0.51 -9.89 -0.36 1.47e-21 Menarche (age at onset); BRCA cis rs3849570 0.695 rs1851930 chr3:81895318 T/G cg07356753 chr3:81810745 GBE1 -0.42 -10.11 -0.37 2.11e-22 Waist circumference;Body mass index; BRCA cis rs6546550 0.900 rs2054047 chr2:70117421 A/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.6 -0.42 2.21e-28 Prevalent atrial fibrillation; BRCA cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.45e-16 Bipolar disorder; BRCA cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg14963724 chr18:72166303 CNDP2 -0.34 -9.43 -0.35 7.58e-20 Refractive error; BRCA cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg23711669 chr6:146136114 FBXO30 0.73 17.61 0.57 6.77e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs7395581 0.918 rs1449627 chr11:47290984 T/G cg25783544 chr11:47291846 MADD 0.43 9.78 0.36 3.68e-21 HDL cholesterol; BRCA cis rs7246657 0.551 rs10404069 chr19:37638404 C/T cg23950597 chr19:37808831 NA -0.55 -8.41 -0.32 2.65e-16 Coronary artery calcification; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg04013093 chr6:42928303 GNMT 0.29 9.73 0.36 5.88e-21 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg06766960 chr11:133703094 NA -0.62 -13.0 -0.46 1.8e-34 Childhood ear infection; BRCA cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.29 9.35 0.35 1.43e-19 Systemic lupus erythematosus; BRCA trans rs6582630 0.555 rs1906260 chr12:38601013 T/G cg06521331 chr12:34319734 NA -0.5 -9.1 -0.34 1.13e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.81 -0.42 3.02e-29 Gut microbiome composition (summer); BRCA cis rs2836974 0.897 rs2776308 chr21:40715175 A/G cg11644478 chr21:40555479 PSMG1 0.76 16.06 0.54 5.46e-49 Cognitive function; BRCA cis rs208515 0.525 rs12215007 chr6:66671008 C/T cg07460842 chr6:66804631 NA -0.87 -15.63 -0.53 7.24e-47 Exhaled nitric oxide levels; BRCA cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg17892150 chr10:133769511 PPP2R2D -0.72 -15.51 -0.52 2.66e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6782228 0.565 rs2811496 chr3:128359958 A/T cg16766828 chr3:128327626 NA -0.42 -9.51 -0.35 3.94e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs35146811 0.735 rs1636978 chr7:99813912 G/A cg22906224 chr7:99728672 NA -0.42 -7.87 -0.3 1.54e-14 Coronary artery disease; BRCA cis rs12611088 0.571 rs7252955 chr19:44021766 A/T cg13740135 chr19:44006432 PHLDB3 -0.3 -7.86 -0.3 1.69e-14 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs1005277 0.579 rs1985707 chr10:38434098 C/T cg25427524 chr10:38739819 LOC399744 -0.68 -16.55 -0.55 1.89e-51 Extrinsic epigenetic age acceleration; BRCA cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.83 -20.73 -0.63 2.24e-73 Birth weight; BRCA cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg26384229 chr12:38710491 ALG10B 0.74 16.99 0.56 1.12e-53 Bladder cancer; BRCA cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg24562669 chr7:97807699 LMTK2 0.66 19.74 0.62 4.64e-68 Breast cancer; BRCA cis rs11690935 0.959 rs76324055 chr2:172620150 T/A cg13550731 chr2:172543902 DYNC1I2 -0.91 -29.23 -0.76 6.7e-120 Schizophrenia; BRCA cis rs477692 1.000 rs531572 chr10:131427569 A/G cg05714579 chr10:131428358 MGMT -0.58 -14.22 -0.49 4.45e-40 Response to temozolomide; BRCA cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.32 -9.64 -0.36 1.3e-20 Autism spectrum disorder or schizophrenia; BRCA trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg15704280 chr7:45808275 SEPT13 0.74 17.45 0.57 4.8e-56 Coronary artery disease; BRCA cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11890956 chr21:40555474 PSMG1 0.99 23.93 0.69 7.69e-91 Cognitive function; BRCA trans rs9388451 0.587 rs1739385 chr6:126099939 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.52 -12.43 -0.44 6.1e-32 Brugada syndrome; BRCA trans rs9291683 0.620 rs717615 chr4:10104670 C/T cg26043149 chr18:55253948 FECH 0.38 8.46 0.32 1.89e-16 Bone mineral density; BRCA cis rs908922 0.676 rs6687126 chr1:152530894 T/G cg20991723 chr1:152506922 NA 0.36 8.13 0.31 2.24e-15 Hair morphology; BRCA cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg11833968 chr6:79620685 NA -0.44 -9.73 -0.36 5.88e-21 Intelligence (multi-trait analysis); BRCA cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg00684032 chr4:1343700 KIAA1530 -0.34 -8.8 -0.33 1.25e-17 Obesity-related traits; BRCA cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.3 0.35 2.25e-19 Rheumatoid arthritis; BRCA cis rs875971 1.000 rs778710 chr7:65854834 T/C cg18876405 chr7:65276391 NA 0.55 13.31 0.47 7.72e-36 Aortic root size; BRCA cis rs1348850 0.608 rs2364845 chr2:178226240 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.4 8.27 0.31 7.56e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg08999081 chr20:33150536 PIGU -0.45 -12.27 -0.44 3.01e-31 Glomerular filtration rate (creatinine); BRCA cis rs7264396 0.563 rs2425084 chr20:34301871 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.69 -12.48 -0.44 3.65e-32 Total cholesterol levels; BRCA cis rs244731 0.919 rs12652509 chr5:176626441 A/G cg06060754 chr5:176797920 RGS14 -0.67 -10.3 -0.38 4.09e-23 Urate levels in lean individuals; BRCA cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3812049 0.693 rs9327468 chr5:127441861 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.57 10.33 0.38 2.98e-23 Lymphocyte counts;Red cell distribution width; BRCA cis rs6456156 0.565 rs2181058 chr6:167465330 A/T cg07741184 chr6:167504864 NA 0.33 9.82 0.36 2.83e-21 Primary biliary cholangitis; BRCA cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg03433033 chr1:76189801 ACADM 0.73 18.87 0.6 1.74e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs34779708 0.966 rs12775759 chr10:35400183 G/T cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.98e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12210905 0.688 rs12194842 chr6:27367978 A/C cg08851530 chr6:28072375 NA 0.84 8.27 0.31 7.64e-16 Hip circumference adjusted for BMI; BRCA cis rs2304069 0.954 rs6579767 chr5:149406271 C/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.57 8.89 0.33 6.41e-18 HIV-1 control; BRCA trans rs7980799 0.565 rs2200159 chr12:33648544 G/C cg26384229 chr12:38710491 ALG10B -0.45 -9.67 -0.36 9.67e-21 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg12011299 chr4:100065546 ADH4 -0.51 -11.79 -0.42 3.6e-29 Alcohol dependence; BRCA cis rs290268 0.874 rs772407 chr9:93560850 A/C cg02608019 chr9:93564028 SYK 0.56 12.41 0.44 7.39e-32 Platelet count; BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg20203395 chr5:56204925 C5orf35 -0.51 -10.45 -0.38 1.08e-23 Initial pursuit acceleration; BRCA cis rs6138458 1.000 rs2387362 chr20:24899906 C/T cg06937882 chr20:24974362 C20orf3 0.44 8.35 0.31 4.34e-16 Blood protein levels; BRCA cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg20887711 chr4:1340912 KIAA1530 0.42 10.29 0.38 4.24e-23 Longevity; BRCA cis rs61931739 0.500 rs9919726 chr12:34510783 A/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.26e-22 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.8e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.943 rs10415937 chr19:37830064 T/G cg18154014 chr19:37997991 ZNF793 0.48 9.5 0.35 4.29e-20 Coronary artery calcification; BRCA cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg13010199 chr12:38710504 ALG10B -0.44 -10.19 -0.37 1.09e-22 Heart rate; BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.98 -0.3 6.81e-15 Total body bone mineral density; BRCA cis rs782590 0.607 rs2061032 chr2:55679490 T/C cg18811423 chr2:55921094 PNPT1 0.46 11.9 0.43 1.29e-29 Metabolic syndrome; BRCA trans rs6582630 0.502 rs11181230 chr12:38300085 A/G cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Drug-induced liver injury (flucloxacillin); BRCA trans rs4689592 0.619 rs2359011 chr4:7066052 T/G cg07817883 chr1:32538562 TMEM39B -0.44 -8.55 -0.32 8.74e-17 Monocyte percentage of white cells; BRCA cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg22903657 chr4:1355424 KIAA1530 -0.36 -8.15 -0.31 1.95e-15 Obesity-related traits; BRCA cis rs4478858 0.735 rs11583123 chr1:31751772 T/C cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs10046574 0.519 rs10265128 chr7:135211446 A/G cg27474649 chr7:135195673 CNOT4 0.64 10.75 0.39 6.98e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1506636 1.000 rs2429616 chr7:123406034 C/T cg03229431 chr7:123269106 ASB15 0.61 13.61 0.47 3.2e-37 Plateletcrit;Platelet count; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg24101359 chr6:42928495 GNMT 0.63 15.45 0.52 5.19e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs3008870 1.000 rs2755240 chr1:67477339 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 21.27 0.64 2.47e-76 Lymphocyte percentage of white cells; BRCA cis rs6842047 1.000 rs4862668 chr4:187136443 A/T cg09526685 chr4:187126073 CYP4V2 0.72 9.93 0.37 1.03e-21 Blood protein levels; BRCA cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg25019033 chr10:957182 NA -0.42 -8.2 -0.31 1.32e-15 Eosinophil percentage of granulocytes; BRCA cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg07828340 chr4:882639 GAK 1.04 12.39 0.44 9.94e-32 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.572 rs2076029 chr6:26390830 T/C cg09904177 chr6:26538194 HMGN4 -0.34 -9.1 -0.34 1.1e-18 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.931 rs10508815 chr10:35332621 A/C cg03585969 chr10:35415529 CREM 0.45 9.48 0.35 4.91e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10751667 0.666 rs7395402 chr11:950293 A/G ch.11.42038R chr11:967971 AP2A2 -0.52 -16.84 -0.55 6.38e-53 Alzheimer's disease (late onset); BRCA cis rs853679 0.517 rs9468292 chr6:28095355 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.02 -0.3 5.22e-15 Depression; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 20.64 0.63 6.21e-73 Platelet count; BRCA cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg24130564 chr14:104152367 KLC1 0.35 7.96 0.3 7.84e-15 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.935 rs430561 chr6:145813140 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.68 0.5 3e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs858239 0.600 rs10488077 chr7:23144182 A/T cg23682824 chr7:23144976 KLHL7 0.42 11.16 0.4 1.52e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg08213375 chr14:104286397 PPP1R13B 0.42 9.1 0.34 1.1e-18 Reticulocyte count; BRCA cis rs2288073 0.562 rs112892911 chr2:24590800 G/A cg06627628 chr2:24431161 ITSN2 -0.8 -15.15 -0.51 1.59e-44 Venous thromboembolism (SNP x SNP interaction); BRCA trans rs6600671 1.000 rs4844616 chr1:121171208 A/G cg17023122 chr1:144479586 NA 0.33 8.02 0.3 4.99e-15 Hip geometry; BRCA cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg22903471 chr2:27725779 GCKR -0.34 -8.16 -0.31 1.72e-15 Total body bone mineral density; BRCA cis rs6598955 0.671 rs8564 chr1:26605069 T/C cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA trans rs11098499 0.820 rs28394116 chr4:120524283 T/G cg25214090 chr10:38739885 LOC399744 0.53 11.53 0.41 4.45e-28 Corneal astigmatism; BRCA cis rs2404602 0.647 rs11072626 chr15:77090826 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.82 -0.48 3.53e-38 Blood metabolite levels; BRCA cis rs796364 0.806 rs79897806 chr2:201073968 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -9.38 -0.35 1.09e-19 Schizophrenia; BRCA cis rs2688608 0.592 rs11000760 chr10:75493734 G/A cg23231163 chr10:75533350 FUT11 -0.33 -8.74 -0.33 2.12e-17 Inflammatory bowel disease; BRCA cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 11.77 0.42 4.57e-29 Calcium levels; BRCA cis rs3008870 0.959 rs3008852 chr1:67383416 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.6 0.65 3.99e-78 Lymphocyte percentage of white cells; BRCA cis rs10046574 0.831 rs56101588 chr7:135128106 A/C cg27474649 chr7:135195673 CNOT4 0.62 8.62 0.32 5.34e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg03517284 chr6:25882590 NA -0.49 -10.27 -0.38 5.31e-23 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg20891283 chr12:69753455 YEATS4 0.72 21.68 0.65 1.6e-78 Blood protein levels; BRCA cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -10.31 -0.38 3.64e-23 Reticulocyte count; BRCA cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg26031613 chr14:104095156 KLC1 -0.45 -8.92 -0.33 5.04e-18 Schizophrenia; BRCA cis rs17401966 0.838 rs12737239 chr1:10323973 C/G cg03954927 chr1:10346856 KIF1B 0.43 13.72 0.48 9.36e-38 Hepatocellular carcinoma; BRCA cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg14019146 chr3:50243930 SLC38A3 -0.34 -8.16 -0.31 1.73e-15 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg05347473 chr6:146136440 FBXO30 -0.42 -8.4 -0.32 2.9e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg19847866 chr10:1019161 NA 0.51 10.43 0.38 1.3e-23 Response to angiotensin II receptor blocker therapy; BRCA trans rs11098499 0.863 rs1552095 chr4:120460306 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.38 8.49 0.32 1.41e-16 Corneal astigmatism; BRCA cis rs372883 0.600 rs2832298 chr21:30743863 C/G cg08807101 chr21:30365312 RNF160 0.45 9.62 0.36 1.5e-20 Pancreatic cancer; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg03923535 chr7:1197113 ZFAND2A 0.5 10.06 0.37 3.5e-22 Longevity;Endometriosis; BRCA cis rs17092148 1.000 rs2425003 chr20:33403584 G/T cg16810054 chr20:33298113 TP53INP2 0.47 10.9 0.4 1.75e-25 Neuroticism; BRCA cis rs10911232 0.507 rs9787327 chr1:182978459 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Hypertriglyceridemia; BRCA cis rs9814567 1.000 rs13071551 chr3:134310867 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.63 0.61 1.63e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 9.19 0.34 5.41e-19 Mean platelet volume; BRCA cis rs72772090 0.539 rs10515248 chr5:96112005 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.08 -0.43 2.05e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 3.79e-25 Bipolar disorder; BRCA cis rs875971 1.000 rs875971 chr7:65617595 A/G cg12463550 chr7:65579703 CRCP -0.36 -7.92 -0.3 1.06e-14 Aortic root size; BRCA trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg25517755 chr10:38738941 LOC399744 -0.37 -7.86 -0.3 1.66e-14 Corneal astigmatism; BRCA cis rs55665837 0.559 rs11023210 chr11:14422762 A/G cg19336497 chr11:14380999 RRAS2 0.44 11.65 0.42 1.48e-28 Vitamin D levels; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg22920501 chr2:26401640 FAM59B -0.81 -12.99 -0.46 2.17e-34 Gut microbiome composition (summer); BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg12016809 chr21:47604291 C21orf56 0.41 8.49 0.32 1.44e-16 Testicular germ cell tumor; BRCA cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg18876405 chr7:65276391 NA 0.55 13.15 0.46 3.95e-35 Aortic root size; BRCA cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg12463550 chr7:65579703 CRCP -0.37 -7.88 -0.3 1.37e-14 Aortic root size; BRCA cis rs7766436 0.614 rs12660580 chr6:22564428 C/G cg13666174 chr6:22585274 NA -0.41 -8.66 -0.32 3.86e-17 Coronary artery disease; BRCA cis rs6665290 0.935 rs6670924 chr1:227196048 A/C cg10327440 chr1:227177885 CDC42BPA -1.15 -48.94 -0.89 2.43e-218 Myeloid white cell count; BRCA cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg14582100 chr15:45693742 SPATA5L1 0.37 12.11 0.43 1.48e-30 Homoarginine levels; BRCA cis rs3825199 0.515 rs2072593 chr12:93970026 T/C cg18151635 chr12:93972918 NA -0.46 -9.16 -0.34 6.91e-19 Height; BRCA cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg18876405 chr7:65276391 NA 0.54 11.99 0.43 4.95e-30 Calcium levels; BRCA trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.96 0.3 8.02e-15 Corneal astigmatism; BRCA cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg12386194 chr3:101231763 SENP7 0.61 12.35 0.44 1.36e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.44e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4803468 1.000 rs284650 chr19:41927129 A/G cg09537434 chr19:41945824 ATP5SL -1.0 -23.66 -0.68 2.44e-89 Height; BRCA cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg11247378 chr22:39784982 NA -0.64 -15.57 -0.52 1.39e-46 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg03146154 chr1:46216737 IPP 0.45 10.04 0.37 4.15e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg08645402 chr16:4508243 NA 0.42 9.32 0.35 1.89e-19 Schizophrenia; BRCA cis rs17253792 0.822 rs75115817 chr14:56069537 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA trans rs629535 0.767 rs72654070 chr8:70079369 G/A cg21567404 chr3:27674614 NA -1.01 -21.77 -0.65 5.17e-79 Dupuytren's disease; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg13628971 chr7:2884303 GNA12 0.46 9.2 0.34 4.83e-19 Height; BRCA cis rs4845875 0.626 rs4845882 chr1:11843167 A/G cg24844545 chr1:11908347 NPPA 0.33 8.22 0.31 1.09e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs1371614 0.610 rs3820822 chr2:27155862 G/A cg00617064 chr2:27272375 NA 0.31 7.82 0.3 2.15e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs367943 0.799 rs10057321 chr5:112974729 A/G cg12552261 chr5:112820674 MCC 0.5 9.9 0.36 1.3e-21 Type 2 diabetes; BRCA cis rs11711311 1.000 rs12632983 chr3:113481913 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.76 -0.39 6.03e-25 IgG glycosylation; BRCA cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg16586182 chr3:47516702 SCAP -0.51 -10.85 -0.39 2.76e-25 Colorectal cancer; BRCA trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.17 0.31 1.61e-15 Corneal astigmatism; BRCA cis rs7385804 0.761 rs507392 chr7:100319936 G/A cg20848291 chr7:100343083 ZAN 0.37 8.36 0.31 4.02e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7116495 0.529 rs575871 chr11:71778822 A/G cg10381502 chr11:71823885 C11orf51 -0.76 -8.93 -0.33 4.62e-18 Severe influenza A (H1N1) infection; BRCA cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg19508488 chr2:152266495 RIF1 0.53 10.98 0.4 8.3e-26 Lung cancer; BRCA cis rs9790314 0.613 rs6809177 chr3:160630477 G/T cg03342759 chr3:160939853 NMD3 0.43 8.66 0.32 3.78e-17 Morning vs. evening chronotype; BRCA cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11644478 chr21:40555479 PSMG1 0.76 15.58 0.52 1.28e-46 Cognitive function; BRCA cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.69 -0.36 8.1e-21 Developmental language disorder (linguistic errors); BRCA cis rs7903847 0.642 rs11812223 chr10:99158455 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.78 -0.33 1.47e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.84 -0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.21 -0.56 7.74e-55 Intelligence (multi-trait analysis); BRCA cis rs7572733 0.534 rs1464211 chr2:198798630 G/A cg00792783 chr2:198669748 PLCL1 0.45 9.93 0.37 1.02e-21 Dermatomyositis; BRCA cis rs11025559 0.812 rs10833336 chr11:20514288 C/G cg19653624 chr11:20408972 PRMT3 -0.41 -9.67 -0.36 9.89e-21 Pursuit maintenance gain; BRCA cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg16339924 chr4:17578868 LAP3 -0.57 -13.46 -0.47 1.49e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12612619 0.732 rs1053609 chr2:27293150 G/T cg00617064 chr2:27272375 NA -0.33 -8.61 -0.32 5.5e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.773 rs13236026 chr7:91885873 A/G cg01689657 chr7:91764605 CYP51A1 0.25 8.65 0.32 4.11e-17 Breast cancer; BRCA trans rs1459104 1.000 rs12797013 chr11:55318288 T/G cg15704280 chr7:45808275 SEPT13 0.63 7.91 0.3 1.13e-14 Body mass index; BRCA cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg06212747 chr3:49208901 KLHDC8B 0.53 8.17 0.31 1.65e-15 Menarche (age at onset); BRCA cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg07148914 chr20:33460835 GGT7 -0.43 -8.83 -0.33 1.01e-17 Glomerular filtration rate (creatinine); BRCA cis rs35146811 0.520 rs1015538 chr7:99626035 A/G cg13334819 chr7:99746414 C7orf59 0.37 9.1 0.34 1.12e-18 Coronary artery disease; BRCA cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg27478167 chr7:817139 HEATR2 0.52 10.16 0.37 1.4e-22 Cerebrospinal P-tau181p levels; BRCA cis rs7191700 0.712 rs7187741 chr16:11433103 C/G cg00044050 chr16:11439710 C16orf75 -0.4 -9.84 -0.36 2.25e-21 Multiple sclerosis; BRCA cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg01877450 chr7:97915802 BRI3 -0.37 -8.57 -0.32 7.96e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.43 -0.44 6.2e-32 Chronic sinus infection; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.76 16.77 0.55 1.41e-52 Lymphocyte counts; BRCA cis rs9359856 0.564 rs17584108 chr6:90458209 T/C cg13799429 chr6:90582589 CASP8AP2 -0.7 -8.44 -0.32 2.16e-16 Bipolar disorder; BRCA cis rs367943 0.698 rs6594746 chr5:112995895 A/C cg12552261 chr5:112820674 MCC -0.4 -9.02 -0.34 2.21e-18 Type 2 diabetes; BRCA cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg26384229 chr12:38710491 ALG10B -0.5 -12.9 -0.45 5.47e-34 Morning vs. evening chronotype; BRCA cis rs4280164 0.945 rs11158632 chr14:24769663 A/C cg16194253 chr14:24768981 DHRS1;C14orf21 -0.46 -7.81 -0.3 2.38e-14 Parent of origin effect on language impairment (paternal); BRCA cis rs7561273 0.609 rs10189243 chr2:24293756 C/T cg04809136 chr2:24300158 SF3B14 -0.4 -9.24 -0.34 3.57e-19 Quantitative traits; BRCA cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.79 0.51 8.75e-43 Colorectal cancer; BRCA cis rs4319547 0.737 rs10773176 chr12:122944713 A/G cg05707623 chr12:122985044 ZCCHC8 -0.45 -9.25 -0.34 3.29e-19 Body mass index; BRCA cis rs11098499 0.604 rs12642411 chr4:120580525 T/C cg09307838 chr4:120376055 NA 0.6 11.03 0.4 5.04e-26 Corneal astigmatism; BRCA cis rs6840360 0.571 rs7685697 chr4:152558849 A/G cg22705602 chr4:152727874 NA -0.32 -8.43 -0.32 2.28e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26314531 chr2:26401878 FAM59B -0.69 -11.56 -0.42 3.21e-28 Gut microbiome composition (summer); BRCA cis rs11716531 0.504 rs648103 chr3:27550301 T/C cg02860705 chr3:27208620 NA -0.41 -8.3 -0.31 5.99e-16 Diastolic blood pressure; BRCA cis rs9816226 0.793 rs869400 chr3:185826740 T/G cg00760338 chr3:185826511 ETV5 0.55 9.2 0.34 5e-19 Obesity;Body mass index; BRCA trans rs75804782 0.641 rs41264155 chr2:239342096 G/A cg01134436 chr17:81009848 B3GNTL1 0.79 9.77 0.36 4.09e-21 Morning vs. evening chronotype;Chronotype; BRCA trans rs75804782 0.630 rs75921156 chr2:239279633 C/T cg01134436 chr17:81009848 B3GNTL1 0.76 8.01 0.3 5.58e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.56 -0.32 8.14e-17 Extrinsic epigenetic age acceleration; BRCA cis rs3931020 0.508 rs4145871 chr1:75218704 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.43 8.26 0.31 8.1e-16 Resistin levels; BRCA cis rs12618769 0.597 rs1587835 chr2:99041269 A/C cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg24558204 chr6:135376177 HBS1L -0.51 -13.8 -0.48 4.02e-38 High light scatter reticulocyte percentage of red cells; BRCA cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg06627557 chr7:32535165 LSM5;AVL9 1.1 31.43 0.78 8.72e-132 Cognitive ability; BRCA cis rs2742417 0.603 rs2253979 chr3:45773320 A/G cg04837898 chr3:45731254 SACM1L -0.38 -7.86 -0.3 1.59e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs7666738 0.546 rs9993299 chr4:98815976 G/A cg05340658 chr4:99064831 C4orf37 0.56 10.8 0.39 4.33e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3862030 0.720 rs7081467 chr10:104231662 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.11e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg12573674 chr2:1569213 NA -0.58 -13.0 -0.46 1.87e-34 IgG glycosylation; BRCA cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.22 0.56 7.24e-55 Bladder cancer; BRCA cis rs1215050 0.791 rs984940 chr4:98811756 T/A cg05340658 chr4:99064831 C4orf37 0.45 10.14 0.37 1.6400000000000001e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg00071950 chr4:10020882 SLC2A9 -0.47 -11.13 -0.4 1.98e-26 Bone mineral density; BRCA cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.45e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg18132916 chr6:79620363 NA -0.46 -10.35 -0.38 2.5e-23 Intelligence (multi-trait analysis); BRCA cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg27489772 chr12:121021490 NA -0.43 -7.94 -0.3 9.1e-15 Type 1 diabetes nephropathy; BRCA cis rs6834538 0.862 rs7659503 chr4:113425304 A/G cg05166686 chr4:113558556 LARP7;C4orf21 -0.36 -8.34 -0.31 4.51e-16 Free thyroxine concentration; BRCA trans rs9291683 0.632 rs11734375 chr4:10046298 A/G cg26043149 chr18:55253948 FECH 0.43 9.29 0.34 2.32e-19 Bone mineral density; BRCA cis rs9837602 1.000 rs7610486 chr3:99732564 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.17 0.4 1.35e-26 Breast cancer; BRCA cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 13.92 0.48 1.2e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg18016565 chr1:150552671 MCL1 0.36 8.19 0.31 1.43e-15 Melanoma; BRCA cis rs701145 0.537 rs449361 chr3:153922410 T/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs17401966 0.540 rs6682868 chr1:10454773 C/T cg03954927 chr1:10346856 KIF1B -0.33 -10.14 -0.37 1.73e-22 Hepatocellular carcinoma; BRCA cis rs992157 0.835 rs11677953 chr2:219121663 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.5 -10.38 -0.38 2.04e-23 Colorectal cancer; BRCA cis rs7917772 0.619 rs2801050 chr10:104509393 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.51 12.37 0.44 1.22e-31 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg06671706 chr8:8559999 CLDN23 0.45 8.54 0.32 9.48e-17 Obesity-related traits; BRCA cis rs34779708 0.931 rs4351760 chr10:35280254 A/G cg03585969 chr10:35415529 CREM 0.56 11.51 0.41 5.36e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg13010199 chr12:38710504 ALG10B 0.43 9.2 0.34 5.11e-19 Morning vs. evening chronotype; BRCA cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg24692254 chr21:30365293 RNF160 -0.68 -18.85 -0.6 2.26e-63 Dental caries; BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 16.73 0.55 2.15e-52 Platelet count; BRCA cis rs698813 0.674 rs11678787 chr2:44496315 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.21 0.31 1.2e-15 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.9 -0.33 5.59e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg26373071 chr5:1325741 CLPTM1L 0.49 11.5 0.41 6.25e-28 Lung cancer; BRCA cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.08 0.37 2.77e-22 Bipolar disorder; BRCA cis rs13082711 0.595 rs17681498 chr3:27331258 T/C cg02860705 chr3:27208620 NA 0.75 14.0 0.48 4.94e-39 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.67 0.32 3.67e-17 Glomerular filtration rate (creatinine); BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg09436375 chr6:42928200 GNMT -0.3 -11.04 -0.4 4.56e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg23033748 chr14:75592666 NEK9 -0.38 -9.15 -0.34 7.77e-19 Height; BRCA cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg12365402 chr11:9010492 NRIP3 0.35 7.95 0.3 8.31e-15 Hemoglobin concentration; BRCA cis rs3806843 0.864 rs2531343 chr5:140129346 A/G cg16179182 chr5:140090404 VTRNA1-1 0.41 9.24 0.34 3.54e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs1113500 0.787 rs4571989 chr1:108631344 G/A cg06207961 chr1:108661230 NA 0.36 8.83 0.33 1e-17 Growth-regulated protein alpha levels; BRCA trans rs3960554 0.808 rs9801125 chr7:75792451 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 11.95 0.43 7.33e-30 Eotaxin levels; BRCA cis rs17228212 1.000 rs35738694 chr15:67454235 C/G cg26876701 chr15:67458665 SMAD3 -0.47 -9.18 -0.34 5.81e-19 Coronary heart disease; BRCA cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg10932868 chr11:921992 NA 0.49 12.38 0.44 1.09e-31 Alzheimer's disease (late onset); BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg10862848 chr6:42927986 GNMT -0.35 -14.46 -0.5 3.2e-41 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg01028140 chr2:1542097 TPO -0.58 -12.18 -0.43 8e-31 IgG glycosylation; BRCA cis rs7089973 0.604 rs7895830 chr10:116625776 A/G cg23260525 chr10:116636907 FAM160B1 0.3 7.94 0.3 9.17e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg16339924 chr4:17578868 LAP3 -0.71 -16.42 -0.54 8.69e-51 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs738321 0.757 rs4821748 chr22:38541936 G/A cg20207973 chr22:38506712 BAIAP2L2 0.38 9.23 0.34 3.81e-19 Breast cancer; BRCA cis rs875971 0.862 rs778697 chr7:65870426 G/A cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs4727027 0.704 rs12535115 chr7:148895087 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.4 8.34 0.31 4.42e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg25036284 chr2:26402008 FAM59B -0.63 -10.64 -0.39 1.93e-24 Gut microbiome composition (summer); BRCA cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.54 -11.21 -0.41 9.84e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs2387326 0.671 rs10829346 chr10:129946104 C/T cg16087940 chr10:129947807 NA -0.46 -8.23 -0.31 1.05e-15 Select biomarker traits; BRCA cis rs9467773 1.000 rs9461259 chr6:26504835 C/A cg11502198 chr6:26597334 ABT1 0.47 9.48 0.35 4.75e-20 Intelligence (multi-trait analysis); BRCA cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg13628971 chr7:2884303 GNA12 0.38 8.52 0.32 1.18e-16 Height; BRCA cis rs10927875 1.000 rs12138117 chr1:16305279 T/C cg21385522 chr1:16154831 NA -0.62 -11.61 -0.42 2.14e-28 Dilated cardiomyopathy; BRCA cis rs4808199 0.895 rs2285628 chr19:19467996 T/A cg03709012 chr19:19516395 GATAD2A 0.91 16.66 0.55 4.81e-52 Nonalcoholic fatty liver disease; BRCA cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.88 -0.56 4.06e-53 Extrinsic epigenetic age acceleration; BRCA cis rs7818345 0.967 rs4554480 chr8:19284072 G/A cg11303988 chr8:19266685 CSGALNACT1 0.31 8.22 0.31 1.12e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg22875332 chr1:76189707 ACADM 0.64 11.42 0.41 1.32e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4561483 0.799 rs33635 chr16:11991944 C/T cg08843971 chr16:11963173 GSPT1 -0.44 -9.21 -0.34 4.76e-19 Testicular germ cell tumor; BRCA cis rs11098499 0.722 rs28713555 chr4:120251995 C/T cg09307838 chr4:120376055 NA 0.65 14.19 0.49 6.52e-40 Corneal astigmatism; BRCA cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg13319975 chr6:146136371 FBXO30 0.45 10.38 0.38 1.98e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs950776 0.714 rs615470 chr15:78885988 T/C cg06917634 chr15:78832804 PSMA4 -0.56 -11.9 -0.43 1.27e-29 Sudden cardiac arrest; BRCA cis rs8077889 0.957 rs17742929 chr17:41891437 C/T cg26893861 chr17:41843967 DUSP3 0.78 13.72 0.48 9.49e-38 Triglycerides; BRCA cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs473651 0.935 rs541013 chr2:239336492 G/A cg21699342 chr2:239360505 ASB1 0.53 14.02 0.49 3.75e-39 Multiple system atrophy; BRCA cis rs2243480 0.803 rs35268390 chr7:65416536 C/G cg18252515 chr7:66147081 NA -0.82 -11.87 -0.42 1.69e-29 Diabetic kidney disease; BRCA cis rs1941023 0.584 rs10897057 chr11:60172273 A/T cg08716584 chr11:60157161 MS4A7 -0.42 -9.73 -0.36 5.75e-21 Congenital heart disease (maternal effect); BRCA trans rs10411161 0.702 rs10423835 chr19:52387322 A/G cg22319618 chr22:45562946 NUP50 -0.43 -8.01 -0.3 5.43e-15 Breast cancer; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.42 -0.32 2.48e-16 Bipolar disorder and schizophrenia; BRCA cis rs34779708 0.966 rs12784482 chr10:35446865 A/G cg03585969 chr10:35415529 CREM 0.56 11.58 0.42 2.9e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7254114 0.578 rs3745682 chr19:11313256 C/T cg06870470 chr19:11315767 DOCK6 -0.36 -8.1 -0.31 2.85e-15 Immature fraction of reticulocytes; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg18402987 chr7:1209562 NA 0.85 12.22 0.44 5.38e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7267979 0.899 rs6115213 chr20:25550372 G/A cg08601574 chr20:25228251 PYGB 0.36 8.45 0.32 2.03e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2404602 0.967 rs7174096 chr15:77072400 A/G cg22467129 chr15:76604101 ETFA -0.4 -8.98 -0.33 3.05e-18 Blood metabolite levels; BRCA cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.86 0.62 9.76e-69 Smoking behavior; BRCA cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg07952391 chr2:88470173 THNSL2 0.68 9.27 0.34 2.76e-19 Plasma clusterin levels; BRCA cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg26384229 chr12:38710491 ALG10B 0.69 16.42 0.54 8.54e-51 Drug-induced liver injury (flucloxacillin); BRCA cis rs6121246 0.559 rs6060621 chr20:30261562 G/C cg13852791 chr20:30311386 BCL2L1 0.95 23.01 0.67 8.32e-86 Mean corpuscular hemoglobin; BRCA trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg15704280 chr7:45808275 SEPT13 -0.82 -20.37 -0.63 1.84e-71 Coronary artery disease; BRCA cis rs17164103 0.505 rs10500136 chr7:143014244 C/T cg15652212 chr7:142981776 TMEM139 -0.7 -13.9 -0.48 1.49e-38 Cancer; BRCA cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 12.95 0.46 3.33e-34 Bipolar disorder; BRCA cis rs12541635 0.677 rs12546875 chr8:107012915 C/T cg10147462 chr8:107024639 NA 0.39 10.61 0.39 2.5e-24 Age of smoking initiation; BRCA cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 11.6 0.42 2.37e-28 Personality dimensions; BRCA cis rs4363385 0.747 rs4845334 chr1:152982998 T/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.99e-16 Inflammatory skin disease; BRCA cis rs3806843 0.966 rs1030163 chr5:140185132 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs858239 0.601 rs2141307 chr7:23191424 G/C cg23682824 chr7:23144976 KLHL7 0.37 9.7 0.36 7.62e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg08045932 chr20:61659980 NA 0.5 11.54 0.42 4.11e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs910316 0.967 rs119076 chr14:75572419 G/T cg08847533 chr14:75593920 NEK9 -0.86 -21.96 -0.66 4.46e-80 Height; BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.83 -0.36 2.48e-21 Schizophrenia; BRCA cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg27446573 chr6:127587934 RNF146 0.86 20.0 0.62 1.76e-69 Breast cancer; BRCA cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.05 0.3 3.98e-15 Parkinson's disease; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg22535103 chr8:58192502 C8orf71 -0.46 -8.16 -0.31 1.74e-15 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.704 rs709282 chr7:2769921 G/A cg04166393 chr7:2884313 GNA12 0.41 8.42 0.32 2.44e-16 Height; BRCA cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.67 0.45 5.84e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs561341 0.941 rs72825746 chr17:30364610 G/A cg12193833 chr17:30244370 NA -0.6 -9.02 -0.34 2.17e-18 Hip circumference adjusted for BMI; BRCA cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1050631 0.592 rs1010955 chr18:33710610 T/C cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.9 -0.3 1.19e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.34 0.31 4.75e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg18876405 chr7:65276391 NA -0.69 -17.9 -0.58 2.12e-58 Aortic root size; BRCA cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg15485101 chr11:133734466 NA 0.41 9.96 0.37 8.41e-22 Childhood ear infection; BRCA cis rs7737355 0.947 rs3776005 chr5:130879003 T/C cg06307176 chr5:131281290 NA 0.53 11.11 0.4 2.37e-26 Life satisfaction; BRCA cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg21609526 chr1:3105151 PRDM16 -0.37 -8.93 -0.33 4.46e-18 Migraine; BRCA cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg15997130 chr1:24165203 NA 0.49 12.94 0.46 3.38e-34 Immature fraction of reticulocytes; BRCA cis rs7833986 1.000 rs34516759 chr8:57097138 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.22 0.31 1.14e-15 Height; BRCA cis rs6450176 0.909 rs3776720 chr5:53296158 A/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.41 -0.5 5.71e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg13256891 chr4:100009986 ADH5 0.4 8.34 0.31 4.42e-16 Alcohol dependence; BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.5 10.07 0.37 3.07e-22 Lymphocyte counts; BRCA cis rs1344694 0.548 rs12468812 chr2:216905867 C/T cg25588852 chr2:216877276 MREG -0.29 -8.09 -0.3 2.98e-15 Alcohol dependence; BRCA cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg23719950 chr11:63933701 MACROD1 -0.59 -10.07 -0.37 3.18e-22 Mean platelet volume; BRCA trans rs877282 0.898 rs11253346 chr10:765313 A/G cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs11229555 0.609 rs12270515 chr11:58217945 G/A cg15696309 chr11:58395628 NA -0.44 -9.47 -0.35 5.21e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.22 0.34 4.33e-19 Morning vs. evening chronotype; BRCA cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.36 0.31 4.07e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.15 -0.34 7.27e-19 Total body bone mineral density; BRCA cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.46 -9.55 -0.35 2.72e-20 Monocyte percentage of white cells; BRCA cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg06494592 chr3:125709126 NA -0.53 -8.2 -0.31 1.32e-15 Blood pressure (smoking interaction); BRCA cis rs9287719 0.967 rs6432117 chr2:10749359 G/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08109568 chr15:31115862 NA 0.42 10.22 0.37 8.26e-23 Huntington's disease progression; BRCA cis rs17095355 1.000 rs12570820 chr10:111732507 G/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.84 -0.36 2.27e-21 Biliary atresia; BRCA cis rs6460942 0.597 rs12699381 chr7:12527026 G/A cg06484146 chr7:12443880 VWDE -0.6 -7.85 -0.3 1.8e-14 Coronary artery disease; BRCA cis rs7584330 0.666 rs72620818 chr2:238354652 G/A cg14458575 chr2:238380390 NA 0.72 15.55 0.52 1.86e-46 Prostate cancer; BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg12444411 chr7:2802554 GNA12 0.34 8.64 0.32 4.41e-17 Height; BRCA cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11890956 chr21:40555474 PSMG1 -1.03 -28.62 -0.75 1.41e-116 Cognitive function; BRCA cis rs4280164 0.945 rs2281472 chr14:24775846 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 0.47 9.08 0.34 1.3e-18 Parent of origin effect on language impairment (paternal); BRCA cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg11584989 chr19:19387371 SF4 0.62 13.0 0.46 1.89e-34 Bipolar disorder; BRCA cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg15412446 chr2:106886593 NA -0.5 -9.18 -0.34 5.69e-19 Facial morphology (factor 23); BRCA cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg24060327 chr5:131705240 SLC22A5 -0.48 -10.02 -0.37 4.79e-22 Blood metabolite levels; BRCA cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.13 0.46 5.01e-35 Electroencephalogram traits; BRCA cis rs8180040 0.967 rs17411375 chr3:47395135 C/T cg27129171 chr3:47204927 SETD2 -0.69 -16.65 -0.55 5.68e-52 Colorectal cancer; BRCA trans rs9951602 0.512 rs8089108 chr18:76651361 C/T cg02800362 chr5:177631904 HNRNPAB 0.77 18.01 0.58 5.8e-59 Obesity-related traits; BRCA cis rs595982 0.559 rs73061643 chr19:49368151 A/G cg21252483 chr19:49399788 TULP2 -0.4 -9.06 -0.34 1.52e-18 Red cell distribution width; BRCA cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg17366294 chr4:99064904 C4orf37 0.41 9.22 0.34 4.31e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs897080 0.515 rs698818 chr2:44709769 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.22 0.34 4.11e-19 Height; BRCA cis rs9527 1.000 rs12416687 chr10:104629011 T/C cg04362960 chr10:104952993 NT5C2 0.52 10.91 0.4 1.51e-25 Arsenic metabolism; BRCA cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05903289 chr2:130345205 NA -0.34 -8.5 -0.32 1.3e-16 Response to cytidine analogues (gemcitabine); BRCA cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.44 0.55 6.47e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs2652822 0.525 rs58789072 chr15:63497553 G/A cg02713581 chr15:63449717 RPS27L 0.41 8.26 0.31 8.09e-16 Metabolic traits; BRCA cis rs17854409 0.881 rs6011430 chr20:61497014 C/T cg07645718 chr20:61493192 TCFL5 -0.59 -8.09 -0.3 3.03e-15 Obesity-related traits; BRCA cis rs4423214 0.840 rs1792231 chr11:71182681 G/A cg05163923 chr11:71159392 DHCR7 -0.56 -11.3 -0.41 4.03e-27 Vitamin D levels; BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg27170947 chr2:26402098 FAM59B -0.7 -11.79 -0.42 3.45e-29 Gut microbiome composition (summer); BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg05279229 chr7:1896384 MAD1L1 -0.41 -7.81 -0.3 2.32e-14 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg05347473 chr6:146136440 FBXO30 -0.46 -9.22 -0.34 4.21e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2645694 0.626 rs2703129 chr4:77818548 T/C cg06046430 chr4:77819534 ANKRD56 0.58 12.97 0.46 2.53e-34 Emphysema distribution in smoking; BRCA cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg20476274 chr7:133979776 SLC35B4 0.58 14.41 0.5 5.64e-41 Mean platelet volume; BRCA cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg25801113 chr15:45476975 SHF 0.31 7.84 0.3 1.93e-14 Uric acid levels; BRCA cis rs875971 0.660 rs801190 chr7:66033033 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.38 -0.31 3.25e-16 Aortic root size; BRCA cis rs2880765 0.743 rs8039049 chr15:86007629 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.37 -0.31 3.57e-16 Coronary artery disease; BRCA cis rs17401966 0.838 rs4846197 chr1:10282166 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.75 0.48 7.29e-38 Hepatocellular carcinoma; BRCA cis rs2425143 1.000 rs78421482 chr20:34376486 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.17 -0.34 6.32e-19 Blood protein levels; BRCA cis rs4363385 0.818 rs61811863 chr1:152995721 T/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.7 -0.33 2.7e-17 Inflammatory skin disease; BRCA cis rs6750047 0.719 rs336035 chr2:38261467 A/G cg07380506 chr2:38303506 CYP1B1 -0.47 -10.68 -0.39 1.32e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg06784218 chr1:46089804 CCDC17 0.52 12.41 0.44 8.07e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs796364 0.906 rs281789 chr2:200780698 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.72 0.42 7.45e-29 Schizophrenia; BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.88 0.43 1.5e-29 Tonsillectomy; BRCA cis rs8062405 1.000 rs62036620 chr16:28833097 A/G cg16576597 chr16:28551801 NUPR1 0.3 8.42 0.32 2.52e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg00071950 chr4:10020882 SLC2A9 0.52 12.84 0.45 9.58e-34 Bone mineral density; BRCA cis rs6834538 1.000 rs1486864 chr4:113465766 G/T cg05166686 chr4:113558556 LARP7;C4orf21 0.39 8.98 0.33 3.13e-18 Free thyroxine concentration; BRCA cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg08847533 chr14:75593920 NEK9 0.81 19.0 0.6 3.87e-64 Height; BRCA cis rs9309711 0.770 rs13409323 chr2:3488184 C/T cg16153549 chr2:3496821 NA -0.4 -9.12 -0.34 1e-18 Neurofibrillary tangles; BRCA cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg00701064 chr4:6280414 WFS1 0.67 17.2 0.56 8.78e-55 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs921968 0.541 rs664514 chr2:219329819 A/G cg10223061 chr2:219282414 VIL1 -0.27 -7.89 -0.3 1.36e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg07636037 chr3:49044803 WDR6 0.42 8.65 0.32 4.2e-17 Resting heart rate; BRCA cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg05665937 chr4:1216051 CTBP1 0.44 8.76 0.33 1.78e-17 Obesity-related traits; BRCA cis rs9287719 0.967 rs10191883 chr2:10744136 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs208515 0.525 rs10944868 chr6:66687508 A/G cg07460842 chr6:66804631 NA 0.77 13.99 0.48 5.51e-39 Exhaled nitric oxide levels; BRCA cis rs7737355 0.947 rs12659474 chr5:130801304 T/C cg06307176 chr5:131281290 NA -0.53 -10.47 -0.38 8.48e-24 Life satisfaction; BRCA cis rs9287719 0.967 rs7593496 chr2:10738176 A/C cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs10267417 0.603 rs10267511 chr7:19896924 A/G cg05791153 chr7:19748676 TWISTNB 0.47 9.05 0.34 1.73e-18 Night sleep phenotypes; BRCA cis rs17641971 0.708 rs1511363 chr8:49901023 C/T cg00325661 chr8:49890786 NA 0.36 9.83 0.36 2.4e-21 Blood metabolite levels; BRCA cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg08859206 chr1:53392774 SCP2 -0.48 -10.65 -0.39 1.77e-24 Monocyte count; BRCA cis rs1891275 0.515 rs2153653 chr10:93495926 T/A cg07889827 chr10:93443413 NA -0.4 -10.8 -0.39 4.34e-25 Intelligence (multi-trait analysis); BRCA trans rs526821 0.595 rs2926309 chr11:55314219 G/A cg11707556 chr5:10655725 ANKRD33B -0.36 -8.11 -0.31 2.54e-15 Pediatric bone mineral density (spine); BRCA cis rs9287719 0.967 rs11687023 chr2:10741412 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.81e-15 Prostate cancer; BRCA cis rs2839186 0.564 rs4819215 chr21:47623573 G/A cg12379764 chr21:47803548 PCNT -0.4 -8.72 -0.33 2.45e-17 Testicular germ cell tumor; BRCA cis rs616402 0.527 rs11584327 chr1:10578791 T/C cg17425144 chr1:10567563 PEX14 0.63 16.75 0.55 1.73e-52 Breast size; BRCA cis rs27434 0.583 rs193482 chr5:96157846 A/G cg16492584 chr5:96139282 ERAP1 -0.5 -12.76 -0.45 2.31e-33 Ankylosing spondylitis; BRCA cis rs11583043 0.918 rs6675403 chr1:101418569 T/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.27 0.34 2.84e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs875971 0.505 rs1167386 chr7:65513096 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -9.46 -0.35 5.8e-20 Aortic root size; BRCA cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.3 0.44 2.29e-31 Multiple sclerosis; BRCA cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg20607798 chr8:58055168 NA 0.47 8.11 0.31 2.6e-15 Developmental language disorder (linguistic errors); BRCA cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg13906792 chr15:75199810 C15orf17 -0.4 -9.48 -0.35 4.77e-20 Breast cancer; BRCA cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg01483505 chr11:975446 AP2A2 0.33 9.01 0.34 2.38e-18 Alzheimer's disease (late onset); BRCA cis rs2742234 0.541 rs61268333 chr10:43721370 G/A cg15436174 chr10:43711423 RASGEF1A 0.53 10.6 0.39 2.8e-24 Hirschsprung disease; BRCA cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.68 0.42 1.1e-28 Homoarginine levels; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg05793240 chr7:2802953 GNA12 -0.32 -8.25 -0.31 9.33e-16 Height; BRCA cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.42 0.38 1.34e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs56399783 0.614 rs55776032 chr7:2762255 T/C cg23627948 chr7:2760692 NA 0.54 8.72 0.33 2.34e-17 Childhood ear infection; BRCA cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg00071950 chr4:10020882 SLC2A9 -0.43 -10.08 -0.37 2.91e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2204008 0.806 rs3922574 chr12:38329069 C/T cg06521331 chr12:34319734 NA -0.49 -8.88 -0.33 6.67e-18 Bladder cancer; BRCA cis rs4660306 1.000 rs7536557 chr1:45992114 T/C cg24296786 chr1:45957014 TESK2 0.45 9.52 0.35 3.51e-20 Homocysteine levels; BRCA cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -8.61 -0.32 5.66e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070997 0.607 rs72765060 chr9:133712404 T/C cg11464064 chr9:133710261 ABL1 0.56 10.1 0.37 2.44e-22 Response to amphetamines; BRCA cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg13010199 chr12:38710504 ALG10B 0.51 9.8 0.36 3.24e-21 Bladder cancer; BRCA cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg08085267 chr17:45401833 C17orf57 -0.62 -13.37 -0.47 4.19e-36 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1018836 0.923 rs4735256 chr8:91612145 C/G cg16814680 chr8:91681699 NA -0.59 -12.55 -0.44 1.91e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs2204008 0.597 rs4002591 chr12:38133841 A/G cg06521331 chr12:34319734 NA -0.5 -9.29 -0.34 2.35e-19 Bladder cancer; BRCA cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.64 -14.26 -0.49 2.8e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg02574844 chr11:5959923 NA 0.41 8.01 0.3 5.32e-15 DNA methylation (variation); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg09177884 chr7:1199841 ZFAND2A -0.43 -9.19 -0.34 5.58e-19 Longevity;Endometriosis; BRCA cis rs2625529 0.824 rs4777475 chr15:72218206 C/T cg16672083 chr15:72433130 SENP8 -0.83 -17.37 -0.57 1.16e-55 Red blood cell count; BRCA trans rs7615952 0.543 rs4645102 chr3:125424441 A/G cg07211511 chr3:129823064 LOC729375 -0.58 -10.46 -0.38 9.92e-24 Blood pressure (smoking interaction); BRCA trans rs11098499 0.908 rs1002152 chr4:120273387 C/A cg25214090 chr10:38739885 LOC399744 0.55 12.37 0.44 1.2e-31 Corneal astigmatism; BRCA cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 1.000 rs12444171 chr16:28845251 G/A cg09754948 chr16:28834200 ATXN2L 0.46 9.13 0.34 9.04e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs8073060 0.544 rs225249 chr17:33942540 T/C cg19694781 chr19:47549865 TMEM160 -1.04 -21.68 -0.65 1.59e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2760061 0.626 rs2796057 chr1:228124414 G/C cg02753203 chr1:228287806 NA -0.58 -12.36 -0.44 1.24e-31 Diastolic blood pressure; BRCA cis rs244731 0.959 rs4976677 chr5:176629546 G/A cg17509989 chr5:176798049 RGS14 -0.73 -11.7 -0.42 8.8e-29 Urate levels in lean individuals; BRCA cis rs12210905 0.688 rs12212348 chr6:27361242 T/C cg08851530 chr6:28072375 NA 0.84 8.3 0.31 6.28e-16 Hip circumference adjusted for BMI; BRCA cis rs1448094 0.512 rs4488288 chr12:86245450 A/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.27 -0.34 2.83e-19 Major depressive disorder; BRCA cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg10523679 chr1:76189770 ACADM -0.47 -9.19 -0.34 5.31e-19 Daytime sleep phenotypes; BRCA cis rs600231 0.577 rs35826299 chr11:65240964 T/C cg01292856 chr11:65242576 NA 0.65 14.83 0.51 5.53e-43 Bone mineral density; BRCA cis rs735396 0.770 rs1169301 chr12:121431300 C/T cg02403541 chr12:121454288 C12orf43 0.63 11.94 0.43 8.23e-30 N-glycan levels; BRCA cis rs1018836 0.892 rs10103198 chr8:91579436 A/T cg16814680 chr8:91681699 NA -0.46 -9.79 -0.36 3.6e-21 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs870825 0.655 rs28661636 chr4:185634218 A/C cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg26031613 chr14:104095156 KLC1 0.7 15.04 0.51 5.51e-44 Body mass index; BRCA cis rs3768617 0.510 rs20558 chr1:183094547 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.77e-18 Motion sickness; BRCA cis rs910316 0.726 rs175040 chr14:75469555 A/G cg11812906 chr14:75593930 NEK9 -0.63 -14.62 -0.5 5.46e-42 Height; BRCA cis rs344364 0.511 rs2917519 chr16:1950479 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -9.73 -0.36 6.09e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs7178424 1.000 rs4775457 chr15:62374915 T/C cg00456672 chr15:62358751 C2CD4A -0.35 -8.3 -0.31 6.42e-16 Height; BRCA cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02018176 chr4:1364513 KIAA1530 -0.41 -8.38 -0.31 3.41e-16 Longevity; BRCA trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg03929089 chr4:120376271 NA -0.69 -13.63 -0.47 2.6e-37 Coronary artery disease; BRCA cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg15839431 chr19:19639596 YJEFN3 0.41 8.97 0.33 3.34e-18 Bipolar disorder; BRCA cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg25019033 chr10:957182 NA -0.42 -8.86 -0.33 7.61e-18 Eosinophil percentage of granulocytes; BRCA cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg03517284 chr6:25882590 NA -0.53 -12.55 -0.44 1.87e-32 Blood metabolite levels; BRCA cis rs3815700 1.000 rs10406750 chr19:33097144 C/T cg02997394 chr19:33096574 ANKRD27 0.69 11.69 0.42 9.23e-29 Eosinophilic esophagitis; BRCA cis rs11971779 0.680 rs6960876 chr7:139112176 C/T cg07862535 chr7:139043722 LUC7L2 -0.4 -10.93 -0.4 1.27e-25 Diisocyanate-induced asthma; BRCA cis rs7246657 0.598 rs10417545 chr19:37654263 C/G cg23950597 chr19:37808831 NA -0.65 -9.98 -0.37 6.76e-22 Coronary artery calcification; BRCA cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg25173405 chr17:45401733 C17orf57 0.52 10.74 0.39 7.4e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs758324 0.947 rs4705835 chr5:131116899 T/C cg06307176 chr5:131281290 NA 0.53 10.27 0.38 5.48e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg03146154 chr1:46216737 IPP -0.45 -9.49 -0.35 4.35e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6450176 1.000 rs7707547 chr5:53295737 A/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.39 -0.49 7.26e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg19418458 chr7:158789849 NA -0.42 -9.43 -0.35 7.42e-20 Facial morphology (factor 20); BRCA cis rs10465746 0.570 rs11163886 chr1:84473445 C/A cg10977910 chr1:84465055 TTLL7 0.54 11.08 0.4 3.22e-26 Obesity-related traits; BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.6 -0.36 1.78e-20 Total body bone mineral density; BRCA cis rs1371867 0.846 rs2047249 chr8:101234126 A/G cg06636551 chr8:101224915 SPAG1 0.37 8.49 0.32 1.45e-16 Atrioventricular conduction; BRCA cis rs7246657 0.943 rs10415024 chr19:37814724 A/G cg23950597 chr19:37808831 NA -0.66 -11.66 -0.42 1.25e-28 Coronary artery calcification; BRCA cis rs9596863 0.950 rs9563183 chr13:54396931 A/C ch.13.53330881F chr13:54432880 NA 0.49 8.22 0.31 1.16e-15 Epilepsy and lamotrigine-induced maculopapular eruptions; BRCA cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg26597838 chr10:835615 NA 1.03 18.39 0.59 6.28e-61 Eosinophil percentage of granulocytes; BRCA cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg16386425 chr10:429943 DIP2C -0.39 -7.94 -0.3 9.39e-15 Psychosis in Alzheimer's disease; BRCA cis rs832540 0.629 rs3309 chr5:56092779 A/T cg24531977 chr5:56204891 C5orf35 0.51 10.76 0.39 6.37e-25 Coronary artery disease; BRCA cis rs17641971 0.599 rs818555 chr8:49999211 A/G cg00325661 chr8:49890786 NA -0.32 -9.04 -0.34 1.87e-18 Blood metabolite levels; BRCA cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg18876405 chr7:65276391 NA 0.54 12.77 0.45 2.1e-33 Aortic root size; BRCA cis rs11051970 0.879 rs950080 chr12:32588503 G/A cg24626660 chr12:32551988 NA 0.29 8.36 0.31 4e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11792861 0.926 rs11788904 chr9:111865052 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.05 0.3 3.95e-15 Menarche (age at onset); BRCA cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg20607287 chr7:12443886 VWDE -0.54 -8.28 -0.31 7.46e-16 Coronary artery disease; BRCA cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg24562669 chr7:97807699 LMTK2 0.71 22.11 0.66 7.41e-81 Breast cancer; BRCA cis rs8028182 0.636 rs28610581 chr15:75812474 A/G cg20655648 chr15:75932815 IMP3 0.41 7.82 0.3 2.13e-14 Sudden cardiac arrest; BRCA cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4363385 0.747 rs9919333 chr1:152968744 G/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.42 -0.35 8e-20 Inflammatory skin disease; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg02353165 chr6:42928485 GNMT 0.87 23.47 0.68 2.46e-88 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg18479299 chr3:125709523 NA -0.53 -8.28 -0.31 7.29e-16 Blood pressure (smoking interaction); BRCA cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg08048268 chr3:133502702 NA 0.34 8.61 0.32 5.56e-17 Iron status biomarkers; BRCA cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -13.65 -0.48 2.11e-37 Hemoglobin concentration; BRCA cis rs3106136 0.546 rs2664880 chr4:95144177 T/A cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.07 -0.37 2.97e-22 Capecitabine sensitivity; BRCA cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg12011299 chr4:100065546 ADH4 0.42 11.11 0.4 2.52e-26 Alcohol dependence; BRCA cis rs910316 0.737 rs175071 chr14:75498177 A/G cg23033748 chr14:75592666 NEK9 -0.37 -8.78 -0.33 1.46e-17 Height; BRCA cis rs7412746 0.658 rs11589458 chr1:150792616 A/G cg18016565 chr1:150552671 MCL1 0.36 8.14 0.31 2.02e-15 Melanoma; BRCA cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.77 -0.55 1.45e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12579753 0.869 rs17692407 chr12:82171369 G/C cg07988820 chr12:82153109 PPFIA2 -0.6 -9.6 -0.35 1.84e-20 Resting heart rate; BRCA trans rs867371 0.502 rs8025964 chr15:82521770 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.34 -8.97 -0.33 3.38e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA trans rs11098499 0.863 rs3775858 chr4:120486028 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.12 0.31 2.44e-15 Corneal astigmatism; BRCA cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg12573674 chr2:1569213 NA -0.51 -9.48 -0.35 4.98e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6752107 0.967 rs36001488 chr2:234185267 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.39 0.41 1.73e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2832077 0.527 rs59730679 chr21:30226244 T/C cg24692254 chr21:30365293 RNF160 -0.52 -11.85 -0.42 1.96e-29 Cognitive test performance; BRCA cis rs1451375 0.794 rs11238133 chr7:50542914 A/C cg18232548 chr7:50535776 DDC -0.49 -12.05 -0.43 2.84e-30 Malaria; BRCA cis rs7267979 1.000 rs6050565 chr20:25347563 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.23 -0.34 3.89e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg06784218 chr1:46089804 CCDC17 0.5 12.3 0.44 2.39e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7647973 0.710 rs6797299 chr3:49609794 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.86 -0.3 1.65e-14 Menarche (age at onset); BRCA cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.47 -0.32 1.7e-16 Monocyte percentage of white cells; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg08805041 chr16:621841 PIGQ -0.29 -7.87 -0.3 1.47e-14 Height; BRCA cis rs4887140 0.867 rs12899897 chr15:74055191 A/C cg11789681 chr15:74046708 NA 0.48 8.31 0.31 5.68e-16 Glucose homeostasis traits; BRCA trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg03929089 chr4:120376271 NA -0.67 -12.9 -0.45 5.55e-34 Coronary artery disease; BRCA cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.16 -0.43 9.45e-31 Electroencephalogram traits; BRCA cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg13770153 chr20:60521292 NA -0.39 -8.94 -0.33 4.09e-18 Body mass index; BRCA cis rs965469 1.000 rs6037533 chr20:3268817 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.23 -0.38 7.7e-23 IFN-related cytopenia; BRCA cis rs12618769 0.597 rs72821951 chr2:99157009 A/C cg10123293 chr2:99228465 UNC50 0.42 8.39 0.32 3.12e-16 Bipolar disorder; BRCA cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg21475434 chr5:93447410 FAM172A 0.7 8.69 0.33 3.02e-17 Diabetic retinopathy; BRCA cis rs332507 0.830 rs62265580 chr3:124359842 C/T cg05980111 chr3:124395277 KALRN 0.36 8.28 0.31 7.09e-16 Plateletcrit; BRCA cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.4 0.49 6.57e-41 Motion sickness; BRCA cis rs2191566 1.000 rs384544 chr19:44505255 A/T cg20607764 chr19:44506953 ZNF230 0.49 10.83 0.39 3.22e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs113835537 0.559 rs11227498 chr11:66269714 A/G cg24851651 chr11:66362959 CCS 0.44 8.27 0.31 7.55e-16 Airway imaging phenotypes; BRCA cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg23719950 chr11:63933701 MACROD1 -0.59 -9.68 -0.36 9.39e-21 Mean platelet volume; BRCA cis rs7520050 0.931 rs6697557 chr1:46307809 G/A cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.4e-21 Red blood cell count;Reticulocyte count; BRCA cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.49 -0.38 7.35e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg19508488 chr2:152266495 RIF1 0.52 10.65 0.39 1.72e-24 Lung cancer; BRCA cis rs877282 0.945 rs10904554 chr10:786768 T/C cg17470449 chr10:769945 NA 0.47 8.16 0.31 1.81e-15 Uric acid levels; BRCA cis rs6715284 1.000 rs13398075 chr2:202376269 A/T cg27024860 chr2:202316456 TRAK2;STRADB 0.67 8.52 0.32 1.14e-16 Rheumatoid arthritis; BRCA cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg16850897 chr7:100343110 ZAN -0.6 -12.41 -0.44 7.65e-32 Other erythrocyte phenotypes; BRCA cis rs1215050 0.740 rs783949 chr4:99001933 A/G cg05340658 chr4:99064831 C4orf37 -0.47 -10.81 -0.39 3.81e-25 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6977660 0.943 rs10274447 chr7:19850640 C/T cg05791153 chr7:19748676 TWISTNB 0.4 8.23 0.31 1.02e-15 Thyroid stimulating hormone; BRCA cis rs708547 0.957 rs1623306 chr4:57773595 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.46 9.8 0.36 3.31e-21 Response to bleomycin (chromatid breaks); BRCA cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg21573476 chr21:45109991 RRP1B 0.32 7.97 0.3 7.22e-15 Mean corpuscular volume; BRCA cis rs3809566 1.000 rs4775610 chr15:63332057 C/T cg12160578 chr15:63334699 TPM1 0.41 8.27 0.31 7.75e-16 Platelet count; BRCA trans rs11098499 0.754 rs1814813 chr4:120258207 G/T cg25214090 chr10:38739885 LOC399744 -0.43 -10.13 -0.37 1.82e-22 Corneal astigmatism; BRCA trans rs1941687 0.527 rs1493914 chr18:31362327 C/T cg27147174 chr7:100797783 AP1S1 -0.54 -10.77 -0.39 5.93e-25 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs4853036 0.951 rs7575302 chr2:70055236 T/C cg02498382 chr2:70120550 SNRNP27 -0.5 -9.21 -0.34 4.49e-19 Colorectal or endometrial cancer; BRCA cis rs1215050 0.765 rs644839 chr4:98716357 C/A cg05340658 chr4:99064831 C4orf37 0.45 10.35 0.38 2.52e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12368653 0.582 rs2307095 chr12:58026001 G/A cg12615879 chr12:58013172 SLC26A10 0.34 9.54 0.35 2.98e-20 Multiple sclerosis; BRCA cis rs7582180 0.700 rs11685293 chr2:100976502 A/C cg14675211 chr2:100938903 LONRF2 0.41 9.16 0.34 6.71e-19 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.545 rs12816776 chr12:39375817 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg27279351 chr12:120934652 DYNLL1 0.57 13.32 0.47 7.06e-36 High light scatter reticulocyte count; BRCA cis rs427394 0.632 rs377137 chr5:6740468 T/G cg10857441 chr5:6722123 POLS -0.32 -10.17 -0.37 1.32e-22 Menopause (age at onset); BRCA cis rs11190604 1.000 rs3750629 chr10:102275727 A/G cg07080220 chr10:102295463 HIF1AN 0.59 14.06 0.49 2.5e-39 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg16145915 chr7:1198662 ZFAND2A -0.43 -9.52 -0.35 3.49e-20 Longevity;Endometriosis; BRCA cis rs11690935 0.959 rs6722757 chr2:172591963 A/G cg13550731 chr2:172543902 DYNC1I2 -0.91 -28.38 -0.75 2.97e-115 Schizophrenia; BRCA cis rs2191566 0.959 rs7255623 chr19:44510906 G/C cg20607764 chr19:44506953 ZNF230 -0.44 -9.95 -0.37 8.47e-22 Acute lymphoblastic leukemia (childhood); BRCA cis rs12210905 0.688 rs12202956 chr6:27356476 T/C cg08851530 chr6:28072375 NA 0.84 8.3 0.31 6.28e-16 Hip circumference adjusted for BMI; BRCA cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.93 22.17 0.66 3.36e-81 Platelet count; BRCA cis rs10162002 0.872 rs3764067 chr13:24042897 T/C cg00158254 chr13:24040743 NA 0.55 8.78 0.33 1.48e-17 Hypothyroidism; BRCA cis rs17102884 0.506 rs887746 chr14:75403817 C/T cg08847533 chr14:75593920 NEK9 -0.46 -9.22 -0.34 4.16e-19 Neuroticism; BRCA cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.57e-23 Motion sickness; BRCA cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg13852791 chr20:30311386 BCL2L1 0.85 16.48 0.55 4.17e-51 Mean corpuscular hemoglobin; BRCA cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg08213375 chr14:104286397 PPP1R13B 0.64 18.21 0.58 5.17e-60 Schizophrenia; BRCA cis rs3857536 0.740 rs7773577 chr6:66892124 G/A cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs6594713 0.531 rs13362189 chr5:112940706 A/G cg12552261 chr5:112820674 MCC 0.46 7.88 0.3 1.38e-14 Brain cytoarchitecture; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6089584 0.854 rs8117075 chr20:60613766 T/C cg06108461 chr20:60628389 TAF4 -0.99 -22.25 -0.66 1.19e-81 Body mass index; BRCA trans rs11098499 0.909 rs7681978 chr4:120383775 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg03929089 chr4:120376271 NA -0.48 -9.04 -0.34 1.81e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg00277334 chr10:82204260 NA -0.85 -24.9 -0.7 3.41e-96 Post bronchodilator FEV1; BRCA cis rs1003719 0.641 rs13046844 chr21:38517603 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.44 -0.5 4e-41 Eye color traits; BRCA cis rs2637266 1.000 rs1077916 chr10:78381951 G/A cg18941641 chr10:78392320 NA 0.35 7.9 0.3 1.21e-14 Pulmonary function; BRCA cis rs11098499 0.532 rs12512646 chr4:120585733 G/A cg09307838 chr4:120376055 NA 0.53 10.47 0.38 8.78e-24 Corneal astigmatism; BRCA trans rs911555 0.662 rs4906322 chr14:103879032 A/G cg17675199 chr6:35436792 RPL10A -0.31 -8.24 -0.31 9.94e-16 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.635 rs2838808 chr21:46621106 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.39 8.23 0.31 1.03e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg11833968 chr6:79620685 NA -0.44 -9.83 -0.36 2.43e-21 Intelligence (multi-trait analysis); BRCA cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg00631329 chr6:26305371 NA -0.55 -15.71 -0.53 2.77e-47 Educational attainment; BRCA cis rs17042140 0.904 rs6540844 chr1:214680378 C/T cg16144317 chr1:214725524 PTPN14 0.34 8.0 0.3 5.94e-15 Plasma thyroid-stimulating hormone levels; BRCA cis rs11190604 1.000 rs10883496 chr10:102221931 T/C cg07080220 chr10:102295463 HIF1AN 0.49 11.29 0.41 4.34e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg08807101 chr21:30365312 RNF160 0.77 20.12 0.62 4.19e-70 Dental caries; BRCA trans rs800082 0.690 rs800081 chr3:144339980 C/T cg24215973 chr2:240111563 HDAC4 0.41 10.11 0.37 2.15e-22 Smoking behavior; BRCA cis rs11229555 0.645 rs10466659 chr11:58190112 A/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg18964960 chr10:1102726 WDR37 0.63 8.83 0.33 9.63e-18 Eosinophil percentage of granulocytes; BRCA cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg07493874 chr5:1342172 CLPTM1L -0.5 -14.11 -0.49 1.57e-39 Lung cancer; BRCA cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.39 -8.05 -0.3 4.1e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4363385 0.667 rs454186 chr1:153049149 C/T cg24667326 chr1:152973720 SPRR3 -0.29 -7.87 -0.3 1.47e-14 Inflammatory skin disease; BRCA cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg06970220 chr1:156163860 SLC25A44 0.38 9.7 0.36 7.46e-21 Testicular germ cell tumor; BRCA cis rs17741873 0.836 rs57771499 chr10:75605492 T/C cg07699608 chr10:75541558 CHCHD1 0.56 8.81 0.33 1.16e-17 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs9341808 0.754 rs1324121 chr6:80946077 A/G cg08355045 chr6:80787529 NA 0.39 10.01 0.37 5.21e-22 Sitting height ratio; BRCA cis rs9341808 0.718 rs910266 chr6:80921170 A/T cg08355045 chr6:80787529 NA 0.39 9.98 0.37 6.89e-22 Sitting height ratio; BRCA cis rs4478137 0.824 rs4691907 chr4:164223658 G/T cg06758707 chr4:164254230 NPY1R 0.57 12.13 0.43 1.28e-30 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -7.93 -0.3 9.72e-15 Longevity;Endometriosis; BRCA trans rs1493916 0.870 rs7235698 chr18:31382486 A/G cg15819921 chr19:927150 ARID3A -0.47 -9.23 -0.34 4.01e-19 Life satisfaction; BRCA cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg26031613 chr14:104095156 KLC1 0.75 16.61 0.55 8.76e-52 Body mass index; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg00149659 chr3:10157352 C3orf10 1.04 17.91 0.58 1.94e-58 Alzheimer's disease; BRCA cis rs7635838 0.718 rs2606736 chr3:11400249 C/T cg00170343 chr3:11313890 ATG7 0.38 7.81 0.3 2.37e-14 HDL cholesterol; BRCA cis rs7917772 0.503 rs10883732 chr10:104293461 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs854765 0.520 rs7219324 chr17:17909775 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.56 -16.96 -0.56 1.46e-53 Total body bone mineral density; BRCA cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg02734326 chr4:10020555 SLC2A9 0.42 9.07 0.34 1.43e-18 Bone mineral density; BRCA cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg10845886 chr2:3471009 TTC15 0.46 9.87 0.36 1.83e-21 Neurofibrillary tangles; BRCA cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg12386194 chr3:101231763 SENP7 0.62 12.07 0.43 2.38e-30 Colonoscopy-negative controls vs population controls; BRCA cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg11266682 chr4:10021025 SLC2A9 -0.37 -9.4 -0.35 9.25e-20 Bone mineral density; BRCA cis rs11105298 0.891 rs4842654 chr12:89834428 T/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.88 -0.36 1.58e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs881375 0.678 rs7037195 chr9:123684000 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.07 0.4 3.55e-26 Rheumatoid arthritis; BRCA cis rs1577917 1.000 rs12199784 chr6:86726808 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.45 -0.44 5.07e-32 Response to antipsychotic treatment; BRCA cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg16339924 chr4:17578868 LAP3 0.63 15.73 0.53 2.27e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4589502 1.000 rs75502100 chr15:67131417 T/C cg09911534 chr15:67153556 NA -0.82 -10.58 -0.39 3.1e-24 Lung cancer (smoking interaction); BRCA cis rs7727544 0.735 rs272860 chr5:131684175 C/G cg07395648 chr5:131743802 NA -0.37 -9.17 -0.34 6.67e-19 Blood metabolite levels; BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg21747090 chr2:27597821 SNX17 -0.43 -9.36 -0.35 1.35e-19 Total body bone mineral density; BRCA cis rs7246657 0.943 rs10405064 chr19:37861861 C/T cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA trans rs1493916 0.807 rs10775455 chr18:31310761 A/C cg27147174 chr7:100797783 AP1S1 -0.38 -7.81 -0.3 2.3e-14 Life satisfaction; BRCA cis rs936229 0.690 rs2472300 chr15:75033909 A/G cg10253484 chr15:75165896 SCAMP2 -0.5 -9.52 -0.35 3.42e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6598955 0.671 rs17257169 chr1:26570009 C/T cg00852783 chr1:26633632 UBXN11 -0.49 -8.11 -0.31 2.57e-15 Obesity-related traits; BRCA cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg06784218 chr1:46089804 CCDC17 0.5 12.17 0.43 8.36e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.2 -0.34 5.21e-19 Menopause (age at onset); BRCA cis rs9790314 0.581 rs6772578 chr3:160760851 T/A cg04691961 chr3:161091175 C3orf57 -0.41 -8.6 -0.32 6.21e-17 Morning vs. evening chronotype; BRCA trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg15704280 chr7:45808275 SEPT13 -0.47 -9.03 -0.34 2.09e-18 Height; BRCA trans rs61931739 0.517 rs11611190 chr12:34015697 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.19 0.34 5.33e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg05707623 chr12:122985044 ZCCHC8 0.52 9.23 0.34 3.91e-19 Body mass index; BRCA cis rs1555322 0.530 rs6060341 chr20:33863633 C/T cg03689076 chr20:33865952 NA -0.53 -9.98 -0.37 6.98e-22 Attention deficit hyperactivity disorder; BRCA cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg12311346 chr5:56204834 C5orf35 -0.48 -9.81 -0.36 2.97e-21 Coronary artery disease; BRCA cis rs7523050 0.643 rs35526993 chr1:109405107 A/T cg08274380 chr1:109419600 GPSM2 0.98 14.02 0.49 3.82e-39 Fat distribution (HIV); BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg02951883 chr7:2050386 MAD1L1 0.49 12.33 0.44 1.82e-31 Bipolar disorder and schizophrenia; BRCA cis rs7914558 1.000 rs6584540 chr10:104927634 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.38 0.38 1.93e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg18230493 chr5:56204884 C5orf35 0.92 17.78 0.58 9.32e-58 Initial pursuit acceleration; BRCA cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 9.48 0.35 4.95e-20 Height; BRCA cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 11.56 0.42 3.29e-28 Bipolar disorder; BRCA trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg07870213 chr5:140052090 DND1 0.79 15.63 0.53 6.79e-47 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs11249608 0.548 rs11960161 chr5:178453837 A/G cg21905437 chr5:178450457 ZNF879 0.52 10.79 0.39 4.69e-25 Pubertal anthropometrics; BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs701145 1.000 rs701145 chr3:154054799 T/C cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA trans rs9329221 0.509 rs3088186 chr8:10226355 C/T cg06636001 chr8:8085503 FLJ10661 0.47 8.37 0.31 3.76e-16 Neuroticism; BRCA cis rs7617480 0.519 rs6790914 chr3:49206318 G/C cg03060546 chr3:49711283 APEH 0.47 9.89 0.36 1.54e-21 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs1215050 0.765 rs471500 chr4:98714820 T/C cg05340658 chr4:99064831 C4orf37 0.45 10.41 0.38 1.48e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7246657 0.943 rs8111782 chr19:37867904 A/G cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA trans rs9858542 0.953 rs35169793 chr3:49423274 A/G cg21659725 chr3:3221576 CRBN -0.45 -9.86 -0.36 1.94e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7587476 0.626 rs7593780 chr2:215640396 C/T cg04004882 chr2:215674386 BARD1 0.39 7.9 0.3 1.23e-14 Neuroblastoma; BRCA cis rs7631605 0.935 rs2302503 chr3:37107470 G/A cg15934958 chr3:37212084 LRRFIP2 0.4 9.05 0.34 1.65e-18 Cerebrospinal P-tau181p levels; BRCA trans rs9858542 0.953 rs9821311 chr3:49543656 C/T cg21659725 chr3:3221576 CRBN -0.46 -9.91 -0.36 1.27e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs870825 0.616 rs7668009 chr4:185641998 A/C cg04058563 chr4:185651563 MLF1IP 0.78 17.63 0.57 5.85e-57 Blood protein levels; BRCA cis rs514406 0.893 rs476108 chr1:53317351 C/T cg16325326 chr1:53192061 ZYG11B 0.69 17.45 0.57 4.78e-56 Monocyte count; BRCA cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.64e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.31 8.46 0.32 1.8e-16 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg07636037 chr3:49044803 WDR6 0.98 29.33 0.76 1.88e-120 Parkinson's disease; BRCA cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg25237894 chr2:233734115 C2orf82 -0.45 -14.26 -0.49 2.93e-40 Coronary artery disease; BRCA cis rs9527 0.590 rs10786744 chr10:104945028 A/C cg04362960 chr10:104952993 NT5C2 -0.42 -9.74 -0.36 5.61e-21 Arsenic metabolism; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg14004847 chr7:1930337 MAD1L1 -0.44 -8.95 -0.33 3.78e-18 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs1691799 0.867 rs1168339 chr12:66759236 T/G cg16791601 chr12:66731901 HELB -0.66 -18.01 -0.58 6.07e-59 White blood cell count (basophil); BRCA cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.21 -0.43 5.77e-31 Tonsillectomy; BRCA cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg12011299 chr4:100065546 ADH4 0.44 11.31 0.41 3.53e-27 Alcohol dependence; BRCA cis rs6723226 0.842 rs2754522 chr2:32801257 C/G cg02381751 chr2:32503542 YIPF4 0.68 14.6 0.5 6.83e-42 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg07636037 chr3:49044803 WDR6 0.97 28.41 0.75 1.86e-115 Parkinson's disease; BRCA trans rs9944715 0.954 rs62096525 chr18:43743820 G/A cg01718231 chr17:29326311 RNF135 0.44 8.97 0.33 3.32e-18 Red cell distribution width;Mean corpuscular volume; BRCA trans rs561341 1.000 rs498391 chr17:30328704 G/A cg27661571 chr11:113659931 NA -0.73 -11.28 -0.41 4.82e-27 Hip circumference adjusted for BMI; BRCA cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg19077165 chr18:44547161 KATNAL2 -0.58 -12.72 -0.45 3.23e-33 Personality dimensions; BRCA cis rs887829 0.570 rs10203266 chr2:234596368 G/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.35 -0.31 4.16e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.8 0.55 9.98e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6752107 1.000 rs2241878 chr2:234183718 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.48 0.41 7.51e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg13319975 chr6:146136371 FBXO30 -0.36 -8.55 -0.32 8.92e-17 Lobe attachment (rater-scored or self-reported); BRCA trans rs8105895 0.735 rs17554694 chr19:22317148 A/G cg05197062 chr11:11642011 GALNTL4 0.53 8.76 0.33 1.71e-17 Body mass index (change over time); BRCA cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg20090143 chr19:45452003 APOC2 0.26 7.96 0.3 7.86e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.56 8.96 0.33 3.41e-18 Mean platelet volume; BRCA cis rs8062405 0.723 rs4788079 chr16:28559363 C/A cg16576597 chr16:28551801 NUPR1 0.35 9.62 0.36 1.5e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg09359103 chr1:154839909 KCNN3 0.56 14.34 0.49 1.26e-40 Prostate cancer; BRCA cis rs6570726 0.967 rs9497316 chr6:145792387 G/T cg23711669 chr6:146136114 FBXO30 -0.62 -14.13 -0.49 1.21e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs7762018 1.000 rs6941766 chr6:170131653 A/G cg19338460 chr6:170058176 WDR27 -0.44 -7.89 -0.3 1.31e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg01324343 chr3:183735012 ABCC5 0.84 21.26 0.64 3.06e-76 Anterior chamber depth; BRCA cis rs921968 0.541 rs4674310 chr2:219318078 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -13.15 -0.46 3.95e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs2073300 0.609 rs1936011 chr20:23341912 G/C cg12062639 chr20:23401060 NAPB 0.94 13.41 0.47 2.59e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs929596 0.501 rs4530361 chr2:234590041 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.53 -0.32 1.09e-16 Total bilirubin levels in HIV-1 infection; BRCA cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.56 12.2 0.43 6.07e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4302748 0.862 rs57651006 chr7:36184211 T/C cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs11585357 0.895 rs72633812 chr1:17623140 T/C cg19159961 chr1:17633534 PADI4 0.57 9.04 0.34 1.84e-18 Hair shape; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 17.74 0.57 1.58e-57 Platelet count; BRCA cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11644478 chr21:40555479 PSMG1 0.83 18.93 0.6 9.26e-64 Cognitive function; BRCA cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg25358565 chr5:93447407 FAM172A -1.13 -17.38 -0.57 1.09e-55 Diabetic retinopathy; BRCA cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.64 -15.32 -0.52 2.32e-45 Chronic sinus infection; BRCA cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg07148914 chr20:33460835 GGT7 0.38 8.57 0.32 7.57e-17 Height; BRCA cis rs11690935 0.589 rs6729945 chr2:172864695 C/G cg13550731 chr2:172543902 DYNC1I2 0.49 12.04 0.43 3.06e-30 Schizophrenia; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg04025307 chr7:1156635 C7orf50 0.55 13.02 0.46 1.51e-34 Longevity;Endometriosis; BRCA cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg11764359 chr7:65958608 NA -0.75 -16.69 -0.55 3.53e-52 Aortic root size; BRCA cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg23711669 chr6:146136114 FBXO30 0.73 17.3 0.56 2.77e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06022373 chr22:39101656 GTPBP1 0.74 18.2 0.58 5.93e-60 Menopause (age at onset); BRCA cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg00990874 chr7:1149470 C7orf50 -0.57 -10.78 -0.39 5.24e-25 Bronchopulmonary dysplasia; BRCA cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg26384229 chr12:38710491 ALG10B 0.65 15.52 0.52 2.53e-46 Drug-induced liver injury (flucloxacillin); BRCA cis rs3862030 0.503 rs6584506 chr10:104254428 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg03923535 chr7:1197113 ZFAND2A -0.4 -7.88 -0.3 1.42e-14 Longevity;Endometriosis; BRCA trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg03929089 chr4:120376271 NA -0.65 -12.05 -0.43 2.71e-30 Coronary artery disease; BRCA cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg10518543 chr12:38710700 ALG10B 0.36 7.88 0.3 1.43e-14 Heart rate; BRCA cis rs8177253 0.632 rs6782523 chr3:133438917 C/T cg11941060 chr3:133502564 NA -0.34 -7.81 -0.3 2.31e-14 Iron status biomarkers; BRCA cis rs10193935 0.901 rs10169411 chr2:42637749 G/A cg27598129 chr2:42591480 NA -0.81 -13.69 -0.48 1.36e-37 Colonoscopy-negative controls vs population controls; BRCA cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.79e-15 Breast cancer; BRCA cis rs11690935 0.550 rs62183785 chr2:172866976 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 12.11 0.43 1.55e-30 Schizophrenia; BRCA cis rs4664304 0.620 rs10186586 chr2:160715334 T/C cg01092293 chr2:160761427 LY75 0.36 8.52 0.32 1.19e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg11833968 chr6:79620685 NA -0.44 -9.89 -0.36 1.53e-21 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg03146154 chr1:46216737 IPP 0.53 11.92 0.43 9.92e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs2486288 0.656 rs11631021 chr15:45556829 A/G cg21132104 chr15:45694354 SPATA5L1 -0.42 -8.55 -0.32 9.38e-17 Glomerular filtration rate; BRCA cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.29 -0.38 4.53e-23 Alzheimer's disease (late onset); BRCA cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 7.92e-24 Motion sickness; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg00149659 chr3:10157352 C3orf10 1.06 18.2 0.58 6.23e-60 Alzheimer's disease; BRCA cis rs2836974 0.830 rs2735309 chr21:40715313 C/T cg11644478 chr21:40555479 PSMG1 0.75 15.99 0.53 1.12e-48 Cognitive function; BRCA cis rs8062405 1.000 rs80275162 chr16:28863517 T/A cg16576597 chr16:28551801 NUPR1 0.3 8.12 0.31 2.49e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg13271783 chr10:134563150 INPP5A -0.51 -9.59 -0.35 1.99e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg13319975 chr6:146136371 FBXO30 -0.34 -8.03 -0.3 4.84e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg25517755 chr10:38738941 LOC399744 -0.37 -7.83 -0.3 2.05e-14 Corneal astigmatism; BRCA cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg08109568 chr15:31115862 NA 0.42 10.24 0.38 7.12e-23 Huntington's disease progression; BRCA cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg08885076 chr2:99613938 TSGA10 -0.49 -11.08 -0.4 3.31e-26 Chronic sinus infection; BRCA cis rs6545883 0.929 rs10173974 chr2:61748900 C/G cg15711740 chr2:61764176 XPO1 -0.54 -13.84 -0.48 2.75e-38 Tuberculosis; BRCA cis rs61931739 0.517 rs11052980 chr12:34036036 T/C cg06521331 chr12:34319734 NA -0.57 -11.43 -0.41 1.17e-27 Morning vs. evening chronotype; BRCA cis rs3892630 0.878 rs8108621 chr19:33183291 G/A cg22980127 chr19:33182716 NUDT19 0.91 18.49 0.59 1.84e-61 Red blood cell traits; BRCA cis rs9463078 0.774 rs6935398 chr6:45262427 G/A cg25276700 chr6:44698697 NA -0.35 -7.95 -0.3 8.26e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.62 19.61 0.61 2.3e-67 Total body bone mineral density; BRCA cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg13319975 chr6:146136371 FBXO30 0.4 9.35 0.35 1.45e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg08132940 chr7:1081526 C7orf50 -0.59 -8.84 -0.33 9.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2635047 0.967 rs12960444 chr18:44607314 T/C cg19077165 chr18:44547161 KATNAL2 -0.43 -9.33 -0.35 1.67e-19 Educational attainment; BRCA cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg13010199 chr12:38710504 ALG10B 0.5 10.17 0.37 1.23e-22 Bladder cancer; BRCA cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg11764359 chr7:65958608 NA 0.62 13.35 0.47 4.82e-36 Aortic root size; BRCA cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.58 0.39 3.38e-24 Motion sickness; BRCA cis rs1577917 0.958 rs12215265 chr6:86443969 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.19 -0.31 1.37e-15 Response to antipsychotic treatment; BRCA cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg20573242 chr4:122745356 CCNA2 0.49 10.9 0.4 1.66e-25 Type 2 diabetes; BRCA cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2404602 0.647 rs118129828 chr15:77015200 T/C cg23625390 chr15:77176239 SCAPER -0.57 -14.54 -0.5 1.39e-41 Blood metabolite levels; BRCA cis rs921943 0.554 rs163132 chr5:78285921 A/G cg18828365 chr5:78281819 ARSB 0.38 7.86 0.3 1.64e-14 Blood and toenail selenium levels;Blood trace element (Se levels); BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.58 -0.52 1.25e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6743226 0.901 rs7592138 chr2:242218915 G/A cg10021735 chr2:242295487 FARP2 0.35 9.61 0.36 1.7e-20 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs7786877 0.723 rs6969584 chr7:100209747 A/C cg20848291 chr7:100343083 ZAN -0.57 -10.65 -0.39 1.66e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs8180040 0.654 rs1466740 chr3:47245883 C/T cg16586182 chr3:47516702 SCAP 0.56 12.57 0.45 1.49e-32 Colorectal cancer; BRCA cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg06238570 chr21:40685208 BRWD1 -0.41 -8.4 -0.32 2.9e-16 Cognitive function; BRCA cis rs7914558 0.966 rs7085598 chr10:104650128 T/C cg04362960 chr10:104952993 NT5C2 0.42 10.14 0.37 1.67e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs34779708 0.966 rs10827493 chr10:35454976 C/T cg03585969 chr10:35415529 CREM 0.5 10.39 0.38 1.73e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs796364 0.789 rs176008 chr2:200814720 A/T cg23649088 chr2:200775458 C2orf69 0.58 8.56 0.32 8.56e-17 Schizophrenia; BRCA cis rs9831754 0.906 rs9840031 chr3:78396140 C/T cg06138941 chr3:78371609 NA 0.75 16.52 0.55 2.61e-51 Calcium levels; BRCA cis rs950776 0.518 rs3813571 chr15:78832792 G/T cg06917634 chr15:78832804 PSMA4 0.8 18.45 0.59 2.97e-61 Sudden cardiac arrest; BRCA cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg01884057 chr2:25150051 NA 0.35 9.22 0.34 4.12e-19 Body mass index; BRCA cis rs2732480 0.557 rs2732484 chr12:48737245 A/C cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 6.07e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg25237894 chr2:233734115 C2orf82 0.39 11.33 0.41 3.13e-27 Coronary artery disease; BRCA cis rs2580764 0.540 rs10174838 chr2:55241216 A/T cg09592903 chr2:55203963 RTN4 -0.41 -10.41 -0.38 1.55e-23 Mean platelet volume; BRCA cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs875971 1.000 rs875971 chr7:65617595 A/G cg11764359 chr7:65958608 NA -0.77 -18.82 -0.6 3.47e-63 Aortic root size; BRCA cis rs3761847 0.593 rs1468673 chr9:123809890 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 8.07 0.3 3.46e-15 Rheumatoid arthritis; BRCA cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg08000102 chr2:233561755 GIGYF2 0.62 13.54 0.47 6.92e-37 Coronary artery disease; BRCA cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg12923728 chr3:195709715 SDHAP1 0.4 9.01 0.34 2.4e-18 Bronchopulmonary dysplasia; BRCA cis rs12367572 0.601 rs1495042 chr12:45434386 C/T cg04608330 chr12:45269318 NELL2 -0.44 -8.93 -0.33 4.6e-18 Gut microbiome composition (summer); BRCA cis rs12612619 0.557 rs1368888 chr2:27068577 G/C cg12368169 chr2:27073192 DPYSL5 -0.33 -10.03 -0.37 4.4e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs701145 0.938 rs355768 chr3:154045001 A/G cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs7677751 0.806 rs890203 chr4:55097405 A/C cg17187183 chr4:55093834 PDGFRA 0.44 9.06 0.34 1.53e-18 Corneal astigmatism; BRCA cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg26384229 chr12:38710491 ALG10B -0.5 -13.15 -0.46 4.15e-35 Morning vs. evening chronotype; BRCA cis rs12681288 0.792 rs4735972 chr8:998618 A/C cg04851639 chr8:1020857 NA -0.34 -10.57 -0.39 3.53e-24 Schizophrenia; BRCA cis rs6063312 1.000 rs11699576 chr20:47349878 A/C cg18078177 chr20:47281410 PREX1 0.64 11.67 0.42 1.2e-28 Tonometry; BRCA cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs1401999 0.966 rs2313216 chr3:183637251 C/T cg20387954 chr3:183756860 HTR3D 0.39 8.84 0.33 9.13e-18 Anterior chamber depth; BRCA cis rs7095944 0.584 rs4962691 chr10:126424137 C/T cg08799069 chr10:126477246 METTL10 -0.36 -8.18 -0.31 1.58e-15 Asthma; BRCA cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg21770322 chr7:97807741 LMTK2 0.42 11.04 0.4 4.89e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs4919694 1.000 rs4917382 chr10:104838510 G/A cg04362960 chr10:104952993 NT5C2 0.94 14.65 0.5 4.14e-42 Arsenic metabolism; BRCA trans rs11098499 0.863 rs28718422 chr4:120466304 C/A cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg21475434 chr5:93447410 FAM172A -0.71 -8.97 -0.33 3.15e-18 Diabetic retinopathy; BRCA cis rs9467773 1.000 rs9986382 chr6:26550619 T/C cg11502198 chr6:26597334 ABT1 0.48 9.67 0.36 9.55e-21 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg11266682 chr4:10021025 SLC2A9 -0.41 -10.83 -0.39 3.42e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6714710 0.580 rs11690737 chr2:98461953 C/T cg26665480 chr2:98280029 ACTR1B 0.57 13.28 0.47 1.05e-35 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs17095355 1.000 rs59804002 chr10:111692043 G/T cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.14 -0.34 8.24e-19 Biliary atresia; BRCA cis rs3845702 1.000 rs3738943 chr2:180846743 G/T cg01881094 chr2:180872142 CWC22 -0.65 -12.68 -0.45 4.85e-33 Schizophrenia; BRCA cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.49 0.38 7.22e-24 Motion sickness; BRCA trans rs11577318 0.853 rs4471263 chr1:26622700 C/T cg07461501 chr17:79650226 HGS;ARL16 0.4 10.21 0.37 9.22e-23 Granulocyte percentage of myeloid white cells; BRCA cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg10560079 chr2:191398806 TMEM194B 0.73 13.08 0.46 8.16e-35 Diastolic blood pressure; BRCA trans rs6951245 0.872 rs112309216 chr7:1100296 A/T cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs1973993 0.691 rs6658131 chr1:96889314 C/T cg10631902 chr5:14652156 NA 0.58 20.44 0.63 7.64e-72 Weight; BRCA cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg06671706 chr8:8559999 CLDN23 0.45 8.76 0.33 1.69e-17 Obesity-related traits; BRCA cis rs9682041 0.932 rs6782252 chr3:170133639 C/T cg11886554 chr3:170076028 SKIL 0.79 13.94 0.48 9.52e-39 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg24642844 chr7:1081250 C7orf50 -0.58 -12.1 -0.43 1.76e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.1 -0.31 2.84e-15 Depression; BRCA cis rs9473147 0.516 rs9395279 chr6:47542864 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.69 0.36 8.01e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg19274703 chr22:41806451 NA 0.39 9.44 0.35 6.82e-20 Vitiligo; BRCA cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.76 -20.74 -0.63 1.86e-73 Chronic sinus infection; BRCA cis rs11105298 0.891 rs10858852 chr12:89833338 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.88 -0.36 1.58e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg08888203 chr3:10149979 C3orf24 0.56 10.24 0.38 7.16e-23 Alzheimer's disease; BRCA cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg11845111 chr2:191398756 TMEM194B 0.43 9.7 0.36 7.73e-21 Pulse pressure; BRCA trans rs2562456 0.917 rs2562466 chr19:21714204 C/T cg25042112 chr7:64838748 ZNF92 0.46 8.47 0.32 1.75e-16 Pain; BRCA cis rs1371867 0.846 rs1660323 chr8:101278724 T/A cg06636551 chr8:101224915 SPAG1 -0.38 -8.52 -0.32 1.18e-16 Atrioventricular conduction; BRCA cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg07636037 chr3:49044803 WDR6 0.98 28.68 0.75 6.29e-117 Parkinson's disease; BRCA cis rs6543140 0.964 rs10193485 chr2:103089573 T/C cg04239558 chr2:103089729 SLC9A4 0.36 9.99 0.37 6.11e-22 Blood protein levels; BRCA trans rs9951602 0.512 rs8084836 chr18:76647841 A/G cg02800362 chr5:177631904 HNRNPAB 0.75 17.5 0.57 2.7e-56 Obesity-related traits; BRCA cis rs1577917 0.958 rs12195776 chr6:86488599 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.95 -0.43 7.7e-30 Response to antipsychotic treatment; BRCA cis rs6901250 1.000 rs6901250 chr6:117114025 A/G cg12892004 chr6:117198278 RFX6 -0.49 -11.61 -0.42 2.14e-28 C-reactive protein levels; BRCA cis rs12413816 0.784 rs11258560 chr10:13770137 A/G cg16485048 chr10:13749193 FRMD4A 0.56 12.58 0.45 1.45e-32 Red cell distribution width; BRCA cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg07395648 chr5:131743802 NA -0.36 -8.04 -0.3 4.33e-15 Breast cancer; BRCA cis rs67460515 0.926 rs13062740 chr3:161024208 G/A cg04691961 chr3:161091175 C3orf57 -0.38 -7.99 -0.3 6.47e-15 Parkinson's disease; BRCA cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg22834771 chr12:69754056 YEATS4 -0.37 -9.06 -0.34 1.6e-18 Blood protein levels; BRCA cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg12386194 chr3:101231763 SENP7 0.62 12.61 0.45 1.05e-32 Colonoscopy-negative controls vs population controls; BRCA cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg15839431 chr19:19639596 YJEFN3 -0.38 -8.43 -0.32 2.26e-16 Bipolar disorder; BRCA cis rs7523050 0.643 rs12741359 chr1:109400489 T/C cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs501916 0.634 rs3743286 chr15:48065792 A/G cg16110827 chr15:48056943 SEMA6D -0.42 -8.78 -0.33 1.52e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg15103426 chr22:29168792 CCDC117 0.52 12.24 0.44 4.34e-31 Lymphocyte counts; BRCA cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg01819863 chr10:32635814 EPC1 1.21 20.9 0.64 2.66e-74 Sexual dysfunction (female); BRCA cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs10463316 0.894 rs11167542 chr5:150760282 A/G cg03212797 chr5:150827313 SLC36A1 0.42 8.05 0.3 4.01e-15 Metabolite levels (Pyroglutamine); BRCA cis rs9875589 0.509 rs4047237 chr3:14012861 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.33 8.67 0.32 3.62e-17 Ovarian reserve; BRCA cis rs17270561 0.636 rs4145218 chr6:25746083 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.18e-17 Iron status biomarkers; BRCA trans rs12517041 1.000 rs1560177 chr5:23322987 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.1 -0.31 2.73e-15 Calcium levels; BRCA cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.89 13.05 0.46 1.07e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1505368 0.781 rs4673664 chr2:213277649 T/C cg16329650 chr2:213403929 ERBB4 0.32 7.99 0.3 6.27e-15 Symmetrical dimethylarginine levels; BRCA cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.16 0.4 1.58e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs75804782 0.641 rs60841092 chr2:239349640 G/A cg01134436 chr17:81009848 B3GNTL1 0.77 9.76 0.36 4.38e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs7809950 1.000 rs28714607 chr7:107106253 T/C cg23024343 chr7:107201750 COG5 -0.42 -9.77 -0.36 4.28e-21 Coronary artery disease; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg22920501 chr2:26401640 FAM59B -0.64 -11.3 -0.41 4.14e-27 Gut microbiome composition (summer); BRCA cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg16325326 chr1:53192061 ZYG11B 0.69 16.99 0.56 1.11e-53 Monocyte count; BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg05793240 chr7:2802953 GNA12 0.32 8.17 0.31 1.61e-15 Height; BRCA cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg06115741 chr20:33292138 TP53INP2 0.38 8.2 0.31 1.27e-15 Glomerular filtration rate (creatinine); BRCA cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg05707623 chr12:122985044 ZCCHC8 -0.49 -9.4 -0.35 9.23e-20 Body mass index; BRCA cis rs1067327 1 rs1067327 chr2:44628529 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.93 0.37 1.08e-21 Anxiety disorder (factor score); BRCA cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg10523679 chr1:76189770 ACADM 0.72 15.15 0.51 1.66e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs753778 0.628 rs11579 chr8:142205132 G/A cg18755752 chr8:142205143 DENND3 -0.63 -16.56 -0.55 1.66e-51 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg25767906 chr1:53392781 SCP2 -0.39 -8.68 -0.32 3.34e-17 Monocyte count; BRCA cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg13010199 chr12:38710504 ALG10B 0.44 8.89 0.33 6.39e-18 Bladder cancer; BRCA cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg03146154 chr1:46216737 IPP -0.47 -10.35 -0.38 2.48e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg22875332 chr1:76189707 ACADM 0.66 11.81 0.42 2.97e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.26 -0.34 3.02e-19 Colorectal cancer; BRCA cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs4984778 0.717 rs2738892 chr16:1268758 A/G cg07748719 chr16:1272498 TPSG1 0.48 9.73 0.36 5.77e-21 Blood protein levels; BRCA cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg24549020 chr5:56110836 MAP3K1 -0.39 -8.2 -0.31 1.28e-15 Initial pursuit acceleration; BRCA cis rs6456156 0.755 rs4710182 chr6:167514061 G/A cg07741184 chr6:167504864 NA 0.32 9.21 0.34 4.6e-19 Primary biliary cholangitis; BRCA cis rs9473147 0.543 rs9296558 chr6:47451883 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.53 0.35 3.2e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs10463316 0.894 rs6579865 chr5:150762335 A/C cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg25036284 chr2:26402008 FAM59B -0.64 -11.04 -0.4 4.7e-26 Gut microbiome composition (summer); BRCA cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.49 -0.38 7.6e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.704 rs709282 chr7:2769921 G/A cg19717773 chr7:2847554 GNA12 -0.42 -9.11 -0.34 1.05e-18 Height; BRCA cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg08000102 chr2:233561755 GIGYF2 -0.63 -13.64 -0.47 2.42e-37 Coronary artery disease; BRCA cis rs6920965 0.527 rs7763515 chr6:126174714 C/G cg05901451 chr6:126070800 HEY2 -0.35 -8.46 -0.32 1.76e-16 High light scatter reticulocyte count; BRCA cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg11707556 chr5:10655725 ANKRD33B -0.48 -12.5 -0.44 3.15e-32 Height; BRCA cis rs9815354 0.761 rs57638657 chr3:41809238 G/C cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg05347473 chr6:146136440 FBXO30 -0.42 -8.34 -0.31 4.51e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs4713118 0.513 rs149958 chr6:28013617 A/C cg10876282 chr6:28092338 ZSCAN16 0.41 7.9 0.3 1.18e-14 Parkinson's disease; BRCA cis rs11249608 0.600 rs6859767 chr5:178451107 T/C cg21905437 chr5:178450457 ZNF879 0.53 11.0 0.4 6.6e-26 Pubertal anthropometrics; BRCA cis rs7607369 0.536 rs6436090 chr2:219669002 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.11 -0.37 2.18e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs208520 1.000 rs72884025 chr6:66994185 T/C cg07460842 chr6:66804631 NA 0.88 14.14 0.49 1.11e-39 Exhaled nitric oxide output; BRCA trans rs35110281 0.774 rs1378080 chr21:45011315 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.49 0.35 4.67e-20 Mean corpuscular volume; BRCA cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.57 0.39 3.5e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs11252926 0.770 rs4880736 chr10:680133 C/G cg08603382 chr10:743973 NA 0.39 8.1 0.31 2.8e-15 Psychosis in Alzheimer's disease; BRCA cis rs17376456 0.877 rs67066109 chr5:93494101 G/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 7.82 0.3 2.15e-14 Diabetic retinopathy; BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.73 -12.9 -0.45 5.43e-34 Gut microbiome composition (summer); BRCA cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs17641971 0.708 rs1567555 chr8:49900154 G/A cg00325661 chr8:49890786 NA 0.35 9.52 0.35 3.37e-20 Blood metabolite levels; BRCA cis rs853679 0.517 rs1853097 chr6:28058635 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.17e-15 Depression; BRCA cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg16414030 chr3:133502952 NA -0.5 -11.61 -0.42 2.01e-28 Iron status biomarkers; BRCA trans rs9325144 0.647 rs7316392 chr12:39064381 T/G cg23762105 chr12:34175262 ALG10 0.35 7.93 0.3 9.86e-15 Morning vs. evening chronotype; BRCA cis rs11191205 0.686 rs11191067 chr10:103379882 G/T cg15320455 chr10:103880129 LDB1 0.46 7.85 0.3 1.82e-14 Intelligence (multi-trait analysis); BRCA cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Depression; BRCA cis rs9880211 0.948 rs9813691 chr3:136260722 T/G cg21827317 chr3:136751795 NA -0.45 -8.15 -0.31 1.89e-15 Body mass index;Height; BRCA cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs10262624 0.528 rs722294 chr7:23746585 A/C cg05804949 chr7:23719620 C7orf46 0.38 8.11 0.31 2.69e-15 Schizophrenia; BRCA cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg13902645 chr11:5959945 NA -0.53 -11.38 -0.41 1.96e-27 DNA methylation (variation); BRCA cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg11766577 chr21:47581405 C21orf56 -0.38 -8.3 -0.31 6.06e-16 Testicular germ cell tumor; BRCA cis rs7561273 0.609 rs10197527 chr2:24352398 A/C cg04809136 chr2:24300158 SF3B14 -0.4 -8.85 -0.33 8.44e-18 Quantitative traits; BRCA trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1801251 0.752 rs2592126 chr2:233751377 A/G cg25237894 chr2:233734115 C2orf82 -0.44 -13.54 -0.47 6.66e-37 Coronary artery disease; BRCA cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 9.32 0.35 1.83e-19 Personality dimensions; BRCA cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.27 0.49 2.73e-40 Motion sickness; BRCA trans rs800082 0.690 rs2717392 chr3:144280080 T/C cg24215973 chr2:240111563 HDAC4 0.4 10.4 0.38 1.58e-23 Smoking behavior; BRCA cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg18357526 chr6:26021779 HIST1H4A -0.47 -8.56 -0.32 8.37e-17 Intelligence (multi-trait analysis); BRCA cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg18129178 chr5:148520854 ABLIM3 -0.6 -12.09 -0.43 1.81e-30 Breast cancer; BRCA cis rs7726839 0.526 rs11960158 chr5:568665 C/T cg09021430 chr5:549028 NA -0.64 -16.44 -0.55 6.66e-51 Obesity-related traits; BRCA cis rs67981189 0.896 rs4391999 chr14:71445413 A/G cg15816911 chr14:71606274 NA 0.36 7.98 0.3 7.01e-15 Schizophrenia; BRCA cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg05283184 chr6:79620031 NA 0.45 11.27 0.41 5.63e-27 Intelligence (multi-trait analysis); BRCA cis rs490234 0.841 rs10114882 chr9:128303425 T/C cg14078157 chr9:128172775 NA -0.48 -10.96 -0.4 9.73e-26 Mean arterial pressure; BRCA cis rs9486719 1.000 rs13210597 chr6:96969694 C/A cg06623918 chr6:96969491 KIAA0776 -0.78 -14.07 -0.49 2.31e-39 Migraine;Coronary artery disease; BRCA cis rs631288 0.557 rs7546434 chr1:146676339 A/G cg25205988 chr1:146714368 CHD1L 0.82 8.08 0.3 3.13e-15 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs7582180 0.607 rs1530029 chr2:100968205 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.49 0.41 6.69e-28 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg04450456 chr4:17643702 FAM184B 0.41 12.17 0.43 8.33e-31 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg23649088 chr2:200775458 C2orf69 0.62 10.62 0.39 2.34e-24 Schizophrenia; BRCA cis rs6430585 0.702 rs3213890 chr2:136552188 G/A cg07169764 chr2:136633963 MCM6 1.27 30.26 0.77 1.84e-125 Corneal structure; BRCA cis rs763121 0.962 rs138711 chr22:39139913 C/T cg06022373 chr22:39101656 GTPBP1 0.6 11.29 0.41 4.48e-27 Menopause (age at onset); BRCA cis rs7582720 0.943 rs72934551 chr2:203984117 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.77 0.45 2.02e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg16230307 chr14:35515116 FAM177A1 0.73 15.28 0.52 3.85e-45 Psoriasis; BRCA cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg10556349 chr10:835070 NA 0.59 8.32 0.31 5.29e-16 Eosinophil percentage of granulocytes; BRCA cis rs2299587 0.560 rs3913556 chr8:17781401 A/G cg01800426 chr8:17659068 MTUS1 -0.35 -8.09 -0.3 3.02e-15 Economic and political preferences; BRCA cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg17063962 chr7:91808500 NA 0.54 12.85 0.45 8.6e-34 Breast cancer; BRCA cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg15448220 chr1:150897856 SETDB1 0.35 7.93 0.3 1e-14 Melanoma; BRCA cis rs921968 0.541 rs17462853 chr2:219345637 T/G cg02176678 chr2:219576539 TTLL4 -0.51 -13.01 -0.46 1.63e-34 Mean corpuscular hemoglobin concentration; BRCA cis rs2806561 0.734 rs2235548 chr1:23394062 G/A cg19743168 chr1:23544995 NA 0.35 8.03 0.3 4.79e-15 Height; BRCA cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg20607798 chr8:58055168 NA 0.49 8.61 0.32 5.61e-17 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg12292205 chr6:26970375 C6orf41 0.74 17.19 0.56 1e-54 Autism spectrum disorder or schizophrenia; BRCA cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg03264133 chr6:25882463 NA -0.53 -11.95 -0.43 7.44e-30 Blood metabolite levels; BRCA cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg06671706 chr8:8559999 CLDN23 0.41 7.95 0.3 8.36e-15 Obesity-related traits; BRCA cis rs7254827 0.655 rs115002674 chr19:17167717 T/G cg19418318 chr19:17219073 MYO9B -0.48 -10.12 -0.37 2.05e-22 Mean platelet volume; BRCA cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg13334819 chr7:99746414 C7orf59 -0.43 -10.05 -0.37 3.76e-22 Coronary artery disease; BRCA cis rs67460515 0.500 rs1345156 chr3:160649272 G/T cg03342759 chr3:160939853 NMD3 0.59 11.81 0.42 2.99e-29 Parkinson's disease; BRCA cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg02951883 chr7:2050386 MAD1L1 -0.39 -8.82 -0.33 1.09e-17 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg23711669 chr6:146136114 FBXO30 0.73 17.53 0.57 1.82e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.97 0.33 3.17e-18 Tonsillectomy; BRCA cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg25237894 chr2:233734115 C2orf82 0.39 11.25 0.41 6.72e-27 Coronary artery disease; BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg00814883 chr7:100076585 TSC22D4 -0.53 -11.81 -0.42 3.06e-29 Platelet count; BRCA cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg06618935 chr21:46677482 NA -0.37 -8.33 -0.31 5e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg27572855 chr1:25598939 RHD 0.47 13.32 0.47 6.43e-36 Erythrocyte sedimentation rate; BRCA cis rs6598955 0.543 rs60676610 chr1:26543421 G/C cg12744634 chr1:26560303 CCDC21 0.31 8.28 0.31 7.39e-16 Obesity-related traits; BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24531977 chr5:56204891 C5orf35 -0.88 -18.06 -0.58 3.1e-59 Initial pursuit acceleration; BRCA cis rs6594499 0.872 rs6880351 chr5:110451664 C/G cg04022379 chr5:110408740 TSLP 0.35 8.02 0.3 4.93e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1348850 0.574 rs2365617 chr2:178421934 C/A cg27490568 chr2:178487706 NA 0.55 8.7 0.33 2.75e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.17 0.31 1.68e-15 Parkinson's disease; BRCA cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9811920 0.809 rs7649349 chr3:99725629 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.56 -13.41 -0.47 2.75e-36 Axial length; BRCA cis rs11958404 0.932 rs11950297 chr5:157419938 T/G cg05962755 chr5:157440814 NA 0.54 10.17 0.37 1.28e-22 IgG glycosylation; BRCA cis rs116139393 0.540 rs12539942 chr7:6776585 C/T cg00318111 chr7:6010084 RSPH10B;RSPH10B2 -0.41 -9.23 -0.34 3.96e-19 Alzheimer's disease (APOE e4 interaction); BRCA cis rs2073300 1.000 rs78000067 chr20:23439507 A/G cg12062639 chr20:23401060 NAPB 0.88 10.42 0.38 1.43e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg13010199 chr12:38710504 ALG10B 0.45 9.28 0.34 2.5e-19 Bladder cancer; BRCA cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg15556689 chr8:8085844 FLJ10661 -0.39 -10.24 -0.38 7.16e-23 Mood instability; BRCA cis rs757110 0.745 rs10734252 chr11:17404839 G/A cg03864215 chr11:17408437 KCNJ11 -0.27 -7.93 -0.3 9.96e-15 Type 2 diabetes; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg16145915 chr7:1198662 ZFAND2A -0.48 -11.51 -0.41 5.35e-28 Longevity;Endometriosis; BRCA cis rs2204008 0.603 rs4397954 chr12:38089157 T/C cg26384229 chr12:38710491 ALG10B 0.77 16.43 0.54 7.53e-51 Bladder cancer; BRCA cis rs10267417 0.603 rs10243346 chr7:19862365 G/A cg05791153 chr7:19748676 TWISTNB 0.51 9.74 0.36 5.38e-21 Night sleep phenotypes; BRCA trans rs11098499 0.542 rs7677836 chr4:120310638 T/A cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg08917208 chr2:24149416 ATAD2B 0.52 8.28 0.31 7.42e-16 Asthma; BRCA trans rs6601450 0.522 rs7837979 chr8:10198534 C/T cg15556689 chr8:8085844 FLJ10661 0.37 9.91 0.36 1.19e-21 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg12373951 chr3:133503437 NA 0.42 10.17 0.37 1.26e-22 Iron status biomarkers; BRCA cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg03146154 chr1:46216737 IPP -0.49 -10.77 -0.39 5.84e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg04414720 chr1:150670196 GOLPH3L -0.38 -8.49 -0.32 1.45e-16 Tonsillectomy; BRCA cis rs67311347 1.000 rs9874499 chr3:40441908 C/T cg09455208 chr3:40491958 NA 0.45 10.84 0.39 3.1e-25 Renal cell carcinoma; BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 24.67 0.7 6.7e-95 Platelet count; BRCA cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg26384229 chr12:38710491 ALG10B -0.56 -13.06 -0.46 1.02e-34 Morning vs. evening chronotype; BRCA trans rs2204008 0.537 rs11170128 chr12:38006632 G/A cg06521331 chr12:34319734 NA -0.53 -9.53 -0.35 3.28e-20 Bladder cancer; BRCA cis rs6598955 0.543 rs6690461 chr1:26543097 T/A cg12744634 chr1:26560303 CCDC21 0.31 8.27 0.31 7.92e-16 Obesity-related traits; BRCA cis rs10129255 0.500 rs2027902 chr14:107215393 T/C cg07958169 chr14:107095056 NA -0.36 -7.89 -0.3 1.28e-14 Kawasaki disease; BRCA cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg26597838 chr10:835615 NA -0.52 -9.61 -0.36 1.63e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs113835537 0.529 rs11227511 chr11:66281244 A/C cg24851651 chr11:66362959 CCS 0.43 8.26 0.31 8.52e-16 Airway imaging phenotypes; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg21226059 chr5:178986404 RUFY1 0.47 12.69 0.45 4.56e-33 Lung cancer; BRCA cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.62 -0.55 8.18e-52 Axial length; BRCA trans rs7618501 0.699 rs2681780 chr3:49897830 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.37 10.21 0.37 9.26e-23 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.771 rs801174 chr5:140112712 C/T cg26395211 chr5:140044315 WDR55 0.38 8.56 0.32 8.49e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg09455208 chr3:40491958 NA 0.51 10.84 0.39 3.02e-25 Renal cell carcinoma; BRCA cis rs11190604 1.000 rs7079136 chr10:102292709 T/C cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1997103 1.000 rs6949244 chr7:55411301 C/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs11874712 1.000 rs28504655 chr18:43665348 G/A cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg13175981 chr1:150552382 MCL1 0.42 9.32 0.35 1.93e-19 Tonsillectomy; BRCA cis rs7131987 0.617 rs3764953 chr12:29502236 T/C cg09582351 chr12:29534625 ERGIC2 -0.48 -10.71 -0.39 9.62e-25 QT interval; BRCA cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg16586182 chr3:47516702 SCAP 0.55 12.17 0.43 9e-31 Colorectal cancer; BRCA cis rs13161895 1.000 rs34674199 chr5:179473900 G/A cg02702477 chr5:179499311 RNF130 0.46 8.53 0.32 1.03e-16 LDL cholesterol; BRCA cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg16506815 chr2:162101123 NA 0.45 9.47 0.35 5.34e-20 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.605 rs7656624 chr4:10121097 T/C cg26043149 chr18:55253948 FECH -0.4 -8.5 -0.32 1.37e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs775227 0.706 rs808951 chr3:113002150 A/G cg18753928 chr3:113234510 CCDC52 0.38 7.96 0.3 7.85e-15 Dental caries; BRCA cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg11663144 chr21:46675770 NA -0.61 -14.22 -0.49 4.45e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2387326 0.717 rs11016101 chr10:129945003 C/T cg16087940 chr10:129947807 NA -0.44 -8.07 -0.3 3.6e-15 Select biomarker traits; BRCA cis rs6835098 1.000 rs10011724 chr4:174088865 A/G cg08422745 chr4:174089978 GALNT7 -0.81 -17.99 -0.58 7.54e-59 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs17270561 0.609 rs1165211 chr6:25800922 T/C cg17691542 chr6:26056736 HIST1H1C 0.43 9.29 0.35 2.29e-19 Iron status biomarkers; BRCA cis rs11779988 0.545 rs438873 chr8:17786516 G/A cg01800426 chr8:17659068 MTUS1 -0.4 -8.37 -0.31 3.65e-16 Breast cancer; BRCA cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg26769984 chr7:1090371 C7orf50 0.39 7.93 0.3 9.86e-15 Bronchopulmonary dysplasia; BRCA cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.77 0.55 1.38e-52 Age-related macular degeneration (geographic atrophy); BRCA cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg20573242 chr4:122745356 CCNA2 0.48 10.84 0.39 2.96e-25 Type 2 diabetes; BRCA cis rs6545883 0.507 rs4672427 chr2:61469250 A/G cg15711740 chr2:61764176 XPO1 0.32 8.01 0.3 5.53e-15 Tuberculosis; BRCA cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg04586622 chr2:25135609 ADCY3 0.36 8.71 0.33 2.66e-17 Body mass index; BRCA cis rs7903847 0.642 rs10882911 chr10:99138064 A/C cg08345082 chr10:99160200 RRP12 -0.29 -8.51 -0.32 1.24e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7254114 0.578 rs12980863 chr19:11309871 C/T cg06870470 chr19:11315767 DOCK6 -0.36 -8.57 -0.32 7.98e-17 Immature fraction of reticulocytes; BRCA cis rs3772130 1.000 rs33988592 chr3:121415610 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.58 0.35 2.07e-20 Cognitive performance; BRCA cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg01475735 chr3:40494733 NA 0.49 10.27 0.38 5.16e-23 Renal cell carcinoma; BRCA cis rs11252926 0.537 rs61836851 chr10:447231 T/C cg16386425 chr10:429943 DIP2C -0.42 -9.02 -0.34 2.17e-18 Psychosis in Alzheimer's disease; BRCA cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg01092293 chr2:160761427 LY75 -0.44 -10.46 -0.38 9.84e-24 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg20476274 chr7:133979776 SLC35B4 0.64 18.19 0.58 6.56e-60 Mean platelet volume; BRCA cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg10845886 chr2:3471009 TTC15 -0.54 -12.15 -0.43 1.0500000000000001e-30 Neurofibrillary tangles; BRCA cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg00321850 chr1:175162397 KIAA0040 0.43 12.38 0.44 1.05e-31 Alcohol dependence; BRCA cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg27572855 chr1:25598939 RHD 0.45 12.85 0.45 8.63e-34 Erythrocyte sedimentation rate; BRCA trans rs6582630 0.502 rs4559747 chr12:38436235 G/A cg06521331 chr12:34319734 NA -0.44 -8.37 -0.31 3.68e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs911555 0.755 rs8014013 chr14:103937372 A/G cg12935359 chr14:103987150 CKB 0.61 14.13 0.49 1.22e-39 Intelligence (multi-trait analysis); BRCA cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.14e-16 Monocyte percentage of white cells; BRCA cis rs7246657 1.000 rs10426297 chr19:37798373 A/G cg14683738 chr19:37701593 ZNF585B 0.5 8.57 0.32 7.72e-17 Coronary artery calcification; BRCA cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg12311346 chr5:56204834 C5orf35 -0.73 -14.47 -0.5 3.11e-41 Initial pursuit acceleration; BRCA cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs4820539 0.966 rs5751587 chr22:23470090 G/A cg14186256 chr22:23484241 RTDR1 0.79 24.79 0.7 1.46e-95 Bone mineral density; BRCA trans rs9650657 0.655 rs1991651 chr8:10706411 C/G cg15556689 chr8:8085844 FLJ10661 0.32 8.21 0.31 1.23e-15 Neuroticism; BRCA cis rs4689388 0.890 rs4689397 chr4:6299387 G/A cg25554036 chr4:6271136 WFS1 0.38 9.28 0.34 2.65e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs13046373 0.508 rs2253516 chr21:31993317 C/T cg22337977 chr21:31811175 KRTAP15-1 0.34 8.01 0.3 5.43e-15 HDL cholesterol; BRCA cis rs4509693 0.941 rs7914169 chr10:102495725 A/G cg24179445 chr10:102496915 NA 0.36 9.68 0.36 9.01e-21 Alzheimer's disease; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg13047869 chr3:10149882 C3orf24 0.53 11.33 0.41 2.9e-27 Alzheimer's disease; BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -14.61 -0.5 6.65e-42 Personality dimensions; BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00149659 chr3:10157352 C3orf10 0.76 12.99 0.46 2.1e-34 Alzheimer's disease; BRCA cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.37 8.25 0.31 9.33e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs508618 1.000 rs508618 chr1:231532312 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.46 -8.27 -0.31 8.01e-16 Red blood cell count; BRCA cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24110177 chr3:50126178 RBM5 -0.37 -9.96 -0.37 7.85e-22 Intelligence (multi-trait analysis); BRCA cis rs8062405 0.895 rs56186137 chr16:28825953 A/G cg16576597 chr16:28551801 NUPR1 0.3 8.41 0.32 2.72e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg12310025 chr6:25882481 NA 0.42 9.43 0.35 7.17e-20 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs778705 chr7:65861115 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg15212455 chr7:39170539 POU6F2 0.43 9.54 0.35 2.9e-20 IgG glycosylation; BRCA cis rs250677 0.522 rs62378210 chr5:148384885 G/A cg18129178 chr5:148520854 ABLIM3 -0.55 -10.58 -0.39 3.39e-24 Breast cancer; BRCA cis rs11098499 0.618 rs35265692 chr4:120325135 T/C cg09307838 chr4:120376055 NA 0.75 16.34 0.54 2.01e-50 Corneal astigmatism; BRCA cis rs1506636 0.886 rs4731112 chr7:123269118 C/G cg03229431 chr7:123269106 ASB15 -0.68 -15.75 -0.53 1.83e-47 Plateletcrit;Platelet count; BRCA cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg13319975 chr6:146136371 FBXO30 0.42 9.78 0.36 3.73e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs11711311 1.000 rs9848993 chr3:113497914 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.54 0.38 4.59e-24 IgG glycosylation; BRCA cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.95e-22 Alzheimer's disease; BRCA cis rs7267979 1.000 rs6083856 chr20:25407585 C/T cg08601574 chr20:25228251 PYGB -0.37 -8.8 -0.33 1.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.78 12.94 0.46 3.53e-34 Platelet count; BRCA trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21659725 chr3:3221576 CRBN -0.5 -12.97 -0.46 2.49e-34 Intelligence (multi-trait analysis); BRCA cis rs7631605 0.935 rs6786857 chr3:37205015 C/T cg15934958 chr3:37212084 LRRFIP2 0.4 9.37 0.35 1.24e-19 Cerebrospinal P-tau181p levels; BRCA cis rs739401 0.527 rs423236 chr11:3065916 C/T cg08508325 chr11:3079039 CARS -0.45 -16.92 -0.56 2.35e-53 Longevity; BRCA cis rs2268241 0.938 rs9978166 chr21:34770516 A/G cg14850771 chr21:34775459 IFNGR2 0.85 17.34 0.57 1.81e-55 Obesity-related traits; BRCA cis rs7582180 0.591 rs62148360 chr2:101006319 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.73 0.42 6.61e-29 Intelligence (multi-trait analysis); BRCA cis rs367943 0.901 rs348951 chr5:112822017 G/C cg12552261 chr5:112820674 MCC -0.55 -12.05 -0.43 2.83e-30 Type 2 diabetes; BRCA cis rs4780401 0.933 rs4584833 chr16:11798758 C/T cg01061890 chr16:11836724 TXNDC11 -0.4 -8.73 -0.33 2.18e-17 Rheumatoid arthritis; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg20607798 chr8:58055168 NA 0.58 9.19 0.34 5.3e-19 Developmental language disorder (linguistic errors); BRCA cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22633769 chr20:60982531 CABLES2 -0.47 -9.37 -0.35 1.24e-19 Colorectal cancer; BRCA cis rs6866344 0.697 rs62392823 chr5:178126968 T/C cg03877680 chr5:178157825 ZNF354A 0.79 14.61 0.5 6.19e-42 Neutrophil percentage of white cells; BRCA cis rs7582180 0.591 rs1030902 chr2:101007178 T/G cg14675211 chr2:100938903 LONRF2 0.47 10.58 0.39 3.33e-24 Intelligence (multi-trait analysis); BRCA cis rs7582180 0.590 rs11123828 chr2:100960918 T/G cg14675211 chr2:100938903 LONRF2 0.45 10.19 0.37 1.06e-22 Intelligence (multi-trait analysis); BRCA cis rs4074536 0.574 rs10754352 chr1:116292369 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 4.94e-17 QRS duration; BRCA cis rs9325144 0.600 rs6582630 chr12:38743508 A/G cg26384229 chr12:38710491 ALG10B -0.52 -13.0 -0.46 1.84e-34 Morning vs. evening chronotype; BRCA trans rs9291683 0.530 rs998675 chr4:9948829 A/G cg26043149 chr18:55253948 FECH 0.39 8.86 0.33 7.79e-18 Bone mineral density; BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg03354898 chr7:1950403 MAD1L1 0.56 12.32 0.44 1.97e-31 Bipolar disorder and schizophrenia; BRCA cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg02175503 chr12:58329896 NA 0.64 15.2 0.52 8.8e-45 Intelligence (multi-trait analysis); BRCA cis rs6763687 0.664 rs9824019 chr3:171806327 T/C cg16233210 chr3:171778391 FNDC3B 0.39 9.19 0.34 5.41e-19 Red cell distribution width; BRCA trans rs11098499 0.779 rs72918579 chr4:120333222 G/C cg25214090 chr10:38739885 LOC399744 0.54 12.41 0.44 8.17e-32 Corneal astigmatism; BRCA cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg26384229 chr12:38710491 ALG10B 0.66 15.61 0.53 8.91e-47 Drug-induced liver injury (flucloxacillin); BRCA cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg08508325 chr11:3079039 CARS 0.35 11.72 0.42 7.2e-29 Longevity; BRCA trans rs7618501 0.501 rs35275715 chr3:49959148 A/G cg21659725 chr3:3221576 CRBN 0.35 8.39 0.32 3.11e-16 Intelligence (multi-trait analysis); BRCA cis rs7398996 1 rs7398996 chr12:53659448 C/T cg26875137 chr12:53738046 NA 0.38 9.72 0.36 6.39e-21 Total body bone mineral density (age 45-60); BRCA cis rs7737355 0.947 rs2108871 chr5:131089044 A/C cg06307176 chr5:131281290 NA 0.53 10.18 0.37 1.16e-22 Life satisfaction; BRCA cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg17971929 chr21:40555470 PSMG1 -0.47 -10.29 -0.38 4.45e-23 Menarche (age at onset); BRCA cis rs67460515 0.563 rs11922959 chr3:160828871 A/G cg03342759 chr3:160939853 NMD3 -0.71 -14.47 -0.5 2.82e-41 Parkinson's disease; BRCA cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs7647973 0.961 rs62259943 chr3:49425167 A/G cg07636037 chr3:49044803 WDR6 -0.77 -15.49 -0.52 3.56e-46 Menarche (age at onset); BRCA cis rs7582180 0.629 rs11123827 chr2:100951248 C/G cg14675211 chr2:100938903 LONRF2 0.51 11.71 0.42 7.77e-29 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.967 rs9525871 chr13:44477712 A/T cg17145862 chr1:211918768 LPGAT1 0.69 18.17 0.58 8.7e-60 Leprosy; BRCA cis rs9287719 0.967 rs7563816 chr2:10763400 C/T cg00105475 chr2:10696890 NA 0.44 10.26 0.38 5.78e-23 Prostate cancer; BRCA cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg06026331 chr20:60912101 LAMA5 0.7 13.26 0.46 1.26e-35 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs897080 0.515 rs1067359 chr2:44661997 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.44 8.35 0.31 4.38e-16 Height; BRCA cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg19748678 chr4:122722346 EXOSC9 0.74 16.19 0.54 1.24e-49 Type 2 diabetes; BRCA cis rs8017423 0.647 rs12882575 chr14:90820454 C/G cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs6546550 0.901 rs7573442 chr2:70154037 G/A cg02498382 chr2:70120550 SNRNP27 -0.52 -11.34 -0.41 2.86e-27 Prevalent atrial fibrillation; BRCA cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg23649088 chr2:200775458 C2orf69 0.6 8.85 0.33 8.7e-18 Schizophrenia; BRCA cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg02734326 chr4:10020555 SLC2A9 0.41 8.99 0.34 2.74e-18 Bone mineral density; BRCA cis rs10267417 0.603 rs10243346 chr7:19862365 G/A cg07541023 chr7:19748670 TWISTNB 0.5 8.92 0.33 4.85e-18 Night sleep phenotypes; BRCA cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg10295955 chr4:187884368 NA -0.99 -31.94 -0.78 1.62e-134 Lobe attachment (rater-scored or self-reported); BRCA cis rs9309473 0.632 rs6546825 chr2:73592253 G/C cg20560298 chr2:73613845 ALMS1 -0.43 -11.15 -0.4 1.72e-26 Metabolite levels; BRCA cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06481639 chr22:41940642 POLR3H -0.61 -9.86 -0.36 1.87e-21 Vitiligo; BRCA cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg24324837 chr19:49891574 CCDC155 0.46 8.54 0.32 9.65e-17 Multiple sclerosis; BRCA cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg11764359 chr7:65958608 NA 0.46 9.02 0.34 2.09e-18 Calcium levels; BRCA cis rs2742234 0.590 rs2505553 chr10:43681251 G/T cg15436174 chr10:43711423 RASGEF1A -0.56 -11.41 -0.41 1.38e-27 Hirschsprung disease; BRCA cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 4.98e-32 Developmental language disorder (linguistic errors); BRCA cis rs8028182 0.636 rs4299117 chr15:75789444 C/T cg20655648 chr15:75932815 IMP3 0.41 7.82 0.3 2.13e-14 Sudden cardiac arrest; BRCA cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs1018836 0.923 rs9694450 chr8:91618292 G/A cg16814680 chr8:91681699 NA -0.58 -12.54 -0.44 2.15e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs698833 1.000 rs698834 chr2:44736957 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.44 0.35 6.84e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs11051970 0.659 rs2728674 chr12:32587465 C/T cg02745156 chr12:32552066 NA 0.26 8.09 0.3 2.98e-15 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg06636001 chr8:8085503 FLJ10661 0.53 11.2 0.41 1.05e-26 Retinal vascular caliber; BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg17414380 chr19:19431394 KIAA0892;SF4 0.42 8.68 0.32 3.27e-17 Tonsillectomy; BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg16606324 chr3:10149918 C3orf24 0.56 10.5 0.38 6.78e-24 Alzheimer's disease; BRCA cis rs4074536 0.622 rs12123600 chr1:116319088 G/A cg21648376 chr1:116311395 CASQ2 -0.55 -9.08 -0.34 1.35e-18 QRS duration; BRCA cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg03213289 chr20:61660250 NA 0.63 16.37 0.54 1.53e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs6977660 1.000 rs7812001 chr7:19803323 A/G cg05791153 chr7:19748676 TWISTNB -0.45 -8.83 -0.33 1.03e-17 Thyroid stimulating hormone; BRCA cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg22676075 chr6:135203613 NA 0.44 8.6 0.32 6.06e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg00031303 chr3:195681400 NA 0.45 8.54 0.32 9.64e-17 Pancreatic cancer; BRCA cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg24130564 chr14:104152367 KLC1 0.35 7.96 0.3 8.02e-15 Intelligence (multi-trait analysis); BRCA cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg27165867 chr14:105738592 BRF1 -0.36 -8.31 -0.31 5.65e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg18016565 chr1:150552671 MCL1 -0.4 -9.19 -0.34 5.61e-19 Blood protein levels; BRCA cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg13902645 chr11:5959945 NA -0.55 -11.27 -0.41 5.3e-27 DNA methylation (variation); BRCA cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.954 rs6848389 chr4:120402622 A/G cg09307838 chr4:120376055 NA 0.71 15.14 0.51 1.85e-44 Corneal astigmatism; BRCA cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg02780029 chr10:43622663 RET 0.35 7.91 0.3 1.14e-14 Hirschsprung disease; BRCA cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs7809615 0.901 rs1581492 chr7:99186826 C/T cg12290671 chr7:99195819 NA -0.51 -8.72 -0.33 2.31e-17 Blood metabolite ratios; BRCA cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg23711669 chr6:146136114 FBXO30 -0.78 -18.71 -0.59 1.35e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.61 12.66 0.45 6.38e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg03433033 chr1:76189801 ACADM 0.75 16.68 0.55 4.04e-52 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12368653 0.607 rs7966795 chr12:58031413 C/A cg12615879 chr12:58013172 SLC26A10 0.35 9.78 0.36 3.73e-21 Multiple sclerosis; BRCA cis rs16910800 0.731 rs16910738 chr11:23189455 C/T cg20040320 chr11:23191996 NA -0.58 -10.16 -0.37 1.44e-22 Cancer; BRCA cis rs4808199 1.000 rs60321073 chr19:19499598 A/G cg03709012 chr19:19516395 GATAD2A 1.11 21.25 0.64 3.38e-76 Nonalcoholic fatty liver disease; BRCA cis rs17539620 0.624 rs62432739 chr6:154835926 A/G cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg05283184 chr6:79620031 NA -0.43 -10.75 -0.39 6.92e-25 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs1892246 chr6:25764408 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 9.44 0.35 6.72e-20 Iron status biomarkers; BRCA cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg02038168 chr22:39784481 NA 0.42 7.87 0.3 1.56e-14 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.559 rs76307631 chr7:107058018 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.23 -0.31 1.03e-15 Coronary artery disease; BRCA cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg11766577 chr21:47581405 C21orf56 -0.41 -8.97 -0.33 3.3e-18 Testicular germ cell tumor; BRCA cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg13319975 chr6:146136371 FBXO30 0.61 13.87 0.48 1.96e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs57590327 0.555 rs13062054 chr3:81833906 A/G cg07356753 chr3:81810745 GBE1 -0.47 -11.02 -0.4 5.63e-26 Extraversion; BRCA cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.07 -0.54 4.52e-49 Alzheimer's disease (late onset); BRCA cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.61 0.36 1.62e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs783540 0.967 rs1145173 chr15:83223425 A/G cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.13 -0.31 2.27e-15 Schizophrenia; BRCA cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.37 7.89 0.3 1.31e-14 Osteoporosis; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg20007245 chr22:24372913 LOC391322 0.58 12.91 0.45 4.76e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs9467773 1.000 rs4871 chr6:26545632 G/A cg09904177 chr6:26538194 HMGN4 0.57 18.47 0.59 2.35e-61 Intelligence (multi-trait analysis); BRCA cis rs943466 1.000 rs6933174 chr6:33751003 G/A cg25922239 chr6:33757077 LEMD2 -0.38 -7.88 -0.3 1.38e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs514406 0.505 rs146750 chr1:53183447 C/G cg08859206 chr1:53392774 SCP2 -0.44 -8.84 -0.33 8.97e-18 Monocyte count; BRCA cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg16230307 chr14:35515116 FAM177A1 -0.73 -15.86 -0.53 5e-48 Psoriasis; BRCA cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg10495392 chr1:46806563 NSUN4 0.44 8.2 0.31 1.37e-15 Menopause (age at onset); BRCA cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg15782153 chr7:917662 C7orf20 -0.39 -9.32 -0.35 1.89e-19 Perceived unattractiveness to mosquitoes; BRCA cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22509189 chr2:225307070 NA -0.46 -9.95 -0.37 8.9e-22 IgE levels in asthmatics (D.p. specific); BRCA cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg12756686 chr19:29218302 NA 0.38 8.06 0.3 3.63e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg26061582 chr7:22766209 IL6 0.39 9.32 0.35 1.83e-19 Lung cancer; BRCA cis rs7666738 0.606 rs4699606 chr4:99095074 A/C cg05340658 chr4:99064831 C4orf37 -0.5 -10.82 -0.39 3.56e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg12591125 chr7:1885375 MAD1L1 0.5 8.88 0.33 6.9e-18 Bipolar disorder; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.54 -9.47 -0.35 5.34e-20 Renal function-related traits (BUN); BRCA cis rs6964587 0.869 rs2023784 chr7:91524677 A/G cg17063962 chr7:91808500 NA -0.51 -11.89 -0.43 1.36e-29 Breast cancer; BRCA cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg24399712 chr22:39784796 NA -0.57 -12.62 -0.45 8.9e-33 Intelligence (multi-trait analysis); BRCA cis rs561341 1.000 rs483301 chr17:30293398 G/T cg00745463 chr17:30367425 LRRC37B -0.6 -9.77 -0.36 4.04e-21 Hip circumference adjusted for BMI; BRCA cis rs11997175 0.766 rs4733176 chr8:33685334 A/T ch.8.33884649F chr8:33765107 NA 0.35 8.09 0.3 2.94e-15 Body mass index; BRCA cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg24642439 chr20:33292090 TP53INP2 0.69 13.82 0.48 3.35e-38 Coronary artery disease; BRCA cis rs67460515 0.892 rs11718905 chr3:161051793 G/A cg03342759 chr3:160939853 NMD3 -0.81 -19.0 -0.6 3.77e-64 Parkinson's disease; BRCA cis rs7829975 0.582 rs6983150 chr8:8792426 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -11.86 -0.42 1.74e-29 Mood instability; BRCA cis rs765787 0.530 rs4238377 chr15:45541981 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.08 0.3 3.2e-15 Uric acid levels; BRCA cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg18230493 chr5:56204884 C5orf35 -0.44 -8.83 -0.33 1.01e-17 Coronary artery disease; BRCA cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg20701182 chr2:24300061 SF3B14 0.55 8.51 0.32 1.21e-16 Lymphocyte counts; BRCA cis rs896854 0.902 rs726816 chr8:95968413 T/G cg13393036 chr8:95962371 TP53INP1 -0.34 -9.18 -0.34 5.75e-19 Type 2 diabetes; BRCA cis rs919433 0.679 rs7564924 chr2:198513877 C/T cg00792783 chr2:198669748 PLCL1 0.41 9.2 0.34 5.22e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg02773041 chr1:40204384 PPIE 0.43 9.25 0.34 3.34e-19 Blood protein levels; BRCA cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg14844989 chr11:31128820 NA -0.44 -9.52 -0.35 3.45e-20 Red blood cell count; BRCA cis rs7103648 0.630 rs7120548 chr11:47662932 A/G cg20307385 chr11:47447363 PSMC3 0.79 18.79 0.6 4.84e-63 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 8.71e-23 Psoriasis; BRCA cis rs11696845 0.666 rs13042905 chr20:43379454 T/C cg25301532 chr20:43378953 KCNK15 0.44 10.41 0.38 1.45e-23 Obesity-related traits; BRCA cis rs8062405 0.965 rs62037363 chr16:28865042 T/C cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg00106254 chr7:1943704 MAD1L1 -0.32 -8.5 -0.32 1.36e-16 Schizophrenia; BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg21226059 chr5:178986404 RUFY1 0.38 9.25 0.34 3.2e-19 Lung cancer; BRCA cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.19 -0.31 1.47e-15 Blood pressure (smoking interaction); BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg00149659 chr3:10157352 C3orf10 0.7 12.11 0.43 1.56e-30 Alzheimer's disease; BRCA cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg15017067 chr4:17643749 FAM184B -0.32 -9.41 -0.35 8.89e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg27446573 chr6:127587934 RNF146 0.9 21.0 0.64 7.01e-75 Breast cancer; BRCA cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg02734326 chr4:10020555 SLC2A9 0.39 8.48 0.32 1.59e-16 Bone mineral density; BRCA trans rs11098499 0.909 rs10017335 chr4:120381523 C/G cg25214090 chr10:38739885 LOC399744 -0.51 -11.0 -0.4 6.75e-26 Corneal astigmatism; BRCA cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg21918786 chr6:109611834 NA -0.47 -13.26 -0.46 1.33e-35 Reticulocyte fraction of red cells; BRCA cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg26513180 chr16:89883248 FANCA 0.78 19.78 0.62 2.62e-68 Vitiligo; BRCA cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg20476274 chr7:133979776 SLC35B4 0.65 18.34 0.59 1.16e-60 Mean platelet volume; BRCA cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.24 0.38 7e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.72 0.33 2.43e-17 Iron status biomarkers; BRCA cis rs7590720 1.000 rs7592663 chr2:216894978 T/C cg12620499 chr2:216877984 MREG 0.8 22.82 0.67 9.79e-85 Alcohol dependence; BRCA cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg11822812 chr5:140052017 DND1 -0.3 -8.22 -0.31 1.14e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg20848291 chr7:100343083 ZAN -0.58 -10.81 -0.39 4.13e-25 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7520050 0.898 rs34175029 chr1:46483871 C/T cg24296786 chr1:45957014 TESK2 0.44 9.84 0.36 2.35e-21 Red blood cell count;Reticulocyte count; BRCA cis rs9527 0.614 rs4919691 chr10:104624475 A/C cg04362960 chr10:104952993 NT5C2 0.41 9.63 0.36 1.38e-20 Arsenic metabolism; BRCA cis rs17092148 1.000 rs1884431 chr20:33338585 G/A cg16810054 chr20:33298113 TP53INP2 -0.49 -11.2 -0.41 1.04e-26 Neuroticism; BRCA cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg16482183 chr6:26056742 HIST1H1C 0.56 11.79 0.42 3.48e-29 Height; BRCA cis rs9790314 0.637 rs7628880 chr3:160743217 C/A cg03342759 chr3:160939853 NMD3 -0.46 -8.88 -0.33 6.53e-18 Morning vs. evening chronotype; BRCA cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg19717773 chr7:2847554 GNA12 -0.41 -9.25 -0.34 3.26e-19 Height; BRCA cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22455342 chr2:225449267 CUL3 0.67 17.24 0.56 5.48e-55 IgE levels in asthmatics (D.p. specific); BRCA cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.83 0.3 1.99e-14 Tonsillectomy; BRCA cis rs243505 0.861 rs243525 chr7:148418140 G/A cg09806900 chr7:148480153 CUL1 -0.4 -8.38 -0.31 3.29e-16 Inflammatory bowel disease;Crohn's disease; BRCA trans rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.37 -8.33 -0.31 4.81e-16 Endometrial cancer; BRCA cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg04450456 chr4:17643702 FAM184B 0.38 11.37 0.41 1.99e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1577917 0.959 rs34258068 chr6:86679449 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.86 -0.42 1.86e-29 Response to antipsychotic treatment; BRCA cis rs9715521 0.557 rs13146381 chr4:59853842 T/C cg11281224 chr4:60001000 NA -0.38 -8.74 -0.33 2.04e-17 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg18402987 chr7:1209562 NA 0.89 14.68 0.5 2.95e-42 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9790314 0.812 rs7631479 chr3:161139566 C/T cg03342759 chr3:160939853 NMD3 -0.52 -11.38 -0.41 1.81e-27 Morning vs. evening chronotype; BRCA cis rs56104184 0.775 rs55737338 chr19:49403141 A/G cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.02e-40 Motion sickness; BRCA cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.25 0.31 9.32e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.06 0.49 2.61e-39 Colorectal cancer; BRCA cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg06238570 chr21:40685208 BRWD1 -0.4 -8.21 -0.31 1.18e-15 Menarche (age at onset); BRCA cis rs6964587 0.869 rs11769294 chr7:91549937 C/T cg17063962 chr7:91808500 NA 0.5 11.56 0.42 3.37e-28 Breast cancer; BRCA cis rs9457247 1.000 rs408918 chr6:167399282 G/T cg00271210 chr6:167070053 RPS6KA2 -0.33 -8.67 -0.32 3.52e-17 Crohn's disease; BRCA cis rs13053817 1.000 rs13057382 chr22:29850334 A/T cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.49 -9.06 -0.34 1.62e-18 Carotid atherosclerosis in HIV infection; BRCA trans rs1973993 0.691 rs4000303 chr1:96913765 A/G cg10631902 chr5:14652156 NA 0.59 21.04 0.64 4.47e-75 Weight; BRCA cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.46 9.46 0.35 5.75e-20 Systemic lupus erythematosus; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg00814883 chr7:100076585 TSC22D4 -0.54 -11.44 -0.41 1.03e-27 Platelet count; BRCA cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.89 14.34 0.49 1.28e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11958404 0.789 rs7736318 chr5:157477593 A/G cg05962755 chr5:157440814 NA 0.54 9.43 0.35 7.74e-20 IgG glycosylation; BRCA trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21659725 chr3:3221576 CRBN 0.48 12.29 0.44 2.61e-31 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg18402987 chr7:1209562 NA 0.58 11.4 0.41 1.55e-27 Longevity;Endometriosis; BRCA cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.71e-15 Uric acid levels; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.14 19.16 0.6 5.23e-65 Platelet count; BRCA cis rs10883723 0.810 rs10786669 chr10:104256094 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2289583 0.517 rs2004278 chr15:75264363 C/T cg14664628 chr15:75095509 CSK 0.51 10.68 0.39 1.28e-24 Systemic lupus erythematosus; BRCA cis rs2046867 0.818 rs34582798 chr3:72882778 A/C cg25664220 chr3:72788482 NA -0.55 -11.8 -0.42 3.14e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg24069376 chr3:38537580 EXOG 0.4 11.43 0.41 1.16e-27 Electrocardiographic conduction measures; BRCA cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg11764359 chr7:65958608 NA -0.64 -11.42 -0.41 1.33e-27 Aortic root size; BRCA cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg13902645 chr11:5959945 NA -0.47 -10.45 -0.38 1.1e-23 DNA methylation (variation); BRCA cis rs6763687 1.000 rs6763687 chr3:171777646 A/T cg16233210 chr3:171778391 FNDC3B 0.44 10.54 0.38 4.47e-24 Red cell distribution width; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.15 0.34 7.78e-19 Platelet count; BRCA cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg13256891 chr4:100009986 ADH5 0.52 9.67 0.36 9.98e-21 Alcohol dependence; BRCA cis rs11249608 0.548 rs6860309 chr5:178451428 T/C cg21905437 chr5:178450457 ZNF879 0.54 11.32 0.41 3.38e-27 Pubertal anthropometrics; BRCA cis rs514406 0.698 rs567880 chr1:53348564 T/G cg27535305 chr1:53392650 SCP2 -0.49 -12.43 -0.44 6.1e-32 Monocyte count; BRCA cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg04944784 chr2:26401820 FAM59B 0.99 16.67 0.55 4.37e-52 Gut microbiome composition (summer); BRCA cis rs9612 1.000 rs8105041 chr19:44258458 A/G cg08581076 chr19:44259116 C19orf61 0.53 9.7 0.36 7.35e-21 Exhaled nitric oxide output; BRCA cis rs495337 0.736 rs595027 chr20:48465722 G/T cg17835207 chr20:48524531 SPATA2 -0.5 -11.06 -0.4 4.03e-26 Psoriasis; BRCA cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.51 11.23 0.41 7.96e-27 Cognitive ability; BRCA cis rs1505368 0.817 rs1283310 chr2:213273891 A/G cg16329650 chr2:213403929 ERBB4 0.34 8.24 0.31 9.53e-16 Symmetrical dimethylarginine levels; BRCA cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg02297831 chr4:17616191 MED28 0.39 9.1 0.34 1.13e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10751667 0.666 rs10902247 chr11:953686 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA cis rs6545883 0.894 rs2694639 chr2:61595291 G/A cg15711740 chr2:61764176 XPO1 0.5 12.34 0.44 1.58e-31 Tuberculosis; BRCA trans rs6461049 0.638 rs3778994 chr7:2175855 G/T cg04565464 chr8:145669602 NFKBIL2 0.37 8.79 0.33 1.32e-17 Schizophrenia; BRCA trans rs6951245 1.000 rs74652290 chr7:1090109 G/A cg13565492 chr6:43139072 SRF -0.7 -10.11 -0.37 2.17e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg18016565 chr1:150552671 MCL1 -0.39 -9.09 -0.34 1.24e-18 Tonsillectomy; BRCA cis rs2346177 0.777 rs7587138 chr2:46657089 A/G cg02822958 chr2:46747628 ATP6V1E2 -0.42 -8.74 -0.33 2.05e-17 HDL cholesterol; BRCA cis rs10267417 0.535 rs6956976 chr7:19869168 G/A cg07541023 chr7:19748670 TWISTNB 0.5 8.95 0.33 3.78e-18 Night sleep phenotypes; BRCA cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg00504896 chr12:9437009 LOC642846 -0.46 -10.05 -0.37 3.66e-22 Breast size; BRCA cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg24558204 chr6:135376177 HBS1L 0.59 16.07 0.54 4.78e-49 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs6687430 0.526 rs12117392 chr1:10608583 T/C cg17425144 chr1:10567563 PEX14 0.57 12.99 0.46 2.05e-34 Hand grip strength; BRCA cis rs2742234 0.656 rs1864400 chr10:43610366 G/A cg15436174 chr10:43711423 RASGEF1A -0.53 -10.68 -0.39 1.26e-24 Hirschsprung disease; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.4 8.73 0.33 2.14e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg24692254 chr21:30365293 RNF160 0.63 14.41 0.5 5.84e-41 Selective IgA deficiency; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg21724239 chr8:58056113 NA 0.62 9.71 0.36 6.96e-21 Developmental language disorder (linguistic errors); BRCA cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.73 14.57 0.5 1.04e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg24088639 chr11:34937564 PDHX;APIP -0.4 -9.05 -0.34 1.74e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg20587970 chr11:113659929 NA -1.24 -22.54 -0.67 3.14e-83 Hip circumference adjusted for BMI; BRCA trans rs17685 0.623 rs7782808 chr7:75768645 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 16.01 0.54 9.5e-49 Platelet count; BRCA cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.58 16.96 0.56 1.46e-53 Total body bone mineral density; BRCA cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg03676636 chr4:99064102 C4orf37 0.24 8.35 0.31 4.34e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs1997103 1.000 rs6951294 chr7:55400835 C/T cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9325144 0.647 rs1875609 chr12:39018259 C/T cg26384229 chr12:38710491 ALG10B -0.48 -11.47 -0.41 8.01e-28 Morning vs. evening chronotype; BRCA cis rs7927771 0.864 rs11600581 chr11:47448497 T/C cg20307385 chr11:47447363 PSMC3 -0.43 -9.19 -0.34 5.38e-19 Subjective well-being; BRCA cis rs12711979 0.509 rs10205540 chr2:3827839 A/G cg17052675 chr2:3827356 NA -0.71 -24.21 -0.69 2.14e-92 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs8028182 0.636 rs4886712 chr15:75812888 C/T cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg13010199 chr12:38710504 ALG10B 0.51 10.04 0.37 3.97e-22 Morning vs. evening chronotype; BRCA trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg25214090 chr10:38739885 LOC399744 0.53 12.03 0.43 3.51e-30 Corneal astigmatism; BRCA trans rs9929218 1.000 rs13334471 chr16:68800452 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.93 -0.48 1.03e-38 Colorectal cancer; BRCA cis rs6450176 1.000 rs6450176 chr5:53298025 G/A ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.08 -0.51 3.62e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs9858542 0.953 rs9859556 chr3:49455986 G/T cg21659725 chr3:3221576 CRBN -0.45 -9.6 -0.36 1.79e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs9291683 0.525 rs12506455 chr4:10031569 T/A cg26043149 chr18:55253948 FECH 0.42 8.98 0.33 3.05e-18 Bone mineral density; BRCA cis rs2797160 0.967 rs926854 chr6:126021780 A/G cg05901451 chr6:126070800 HEY2 0.39 9.43 0.35 7.33e-20 Endometrial cancer; BRCA cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs7267979 0.833 rs4619688 chr20:25244101 C/G cg08601574 chr20:25228251 PYGB 0.41 9.61 0.36 1.64e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs514406 0.679 rs960570 chr1:53237763 A/G cg25767906 chr1:53392781 SCP2 0.52 10.96 0.4 1.02e-25 Monocyte count; BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg13880726 chr7:1868755 MAD1L1 0.51 9.84 0.36 2.24e-21 Autism spectrum disorder or schizophrenia; BRCA cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg24130564 chr14:104152367 KLC1 -0.41 -8.79 -0.33 1.35e-17 Reticulocyte count; BRCA trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg25214090 chr10:38739885 LOC399744 0.54 12.24 0.44 4.06e-31 Corneal astigmatism; BRCA cis rs818427 0.927 rs153546 chr5:112238039 A/C cg07820702 chr5:112228657 REEP5 -0.35 -8.65 -0.32 4.19e-17 Total body bone mineral density; BRCA cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg24060327 chr5:131705240 SLC22A5 0.5 10.36 0.38 2.34e-23 Blood metabolite levels; BRCA cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg10169327 chr19:45448959 APOC2 0.31 7.83 0.3 2.05e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs9858542 0.953 rs4625 chr3:49572140 A/G cg21659725 chr3:3221576 CRBN -0.45 -10.01 -0.37 5.05e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg25036284 chr2:26402008 FAM59B -0.64 -10.61 -0.39 2.57e-24 Gut microbiome composition (summer); BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.89 -18.47 -0.59 2.37e-61 Alzheimer's disease; BRCA cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg26597838 chr10:835615 NA 1.03 18.39 0.59 6.28e-61 Eosinophil percentage of granulocytes; BRCA cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg13628971 chr7:2884303 GNA12 0.39 8.65 0.32 4.24e-17 Height; BRCA cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg06064525 chr11:970664 AP2A2 -0.49 -16.22 -0.54 7.89e-50 Alzheimer's disease (late onset); BRCA cis rs1577917 0.958 rs36042496 chr6:86524214 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs9814567 1.000 rs6769885 chr3:134286913 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.52 -0.61 6.57e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg16606324 chr3:10149918 C3orf24 0.56 10.96 0.4 9.85e-26 Alzheimer's disease; BRCA cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg18876405 chr7:65276391 NA 0.55 13.15 0.46 3.95e-35 Aortic root size; BRCA cis rs427394 0.743 rs274716 chr5:6722289 T/C cg10857441 chr5:6722123 POLS -0.33 -10.71 -0.39 9.57e-25 Menopause (age at onset); BRCA cis rs7267979 1.000 rs4815405 chr20:25317492 T/C cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10465746 0.780 rs11163872 chr1:84421969 G/T cg10977910 chr1:84465055 TTLL7 0.56 11.71 0.42 8.2e-29 Obesity-related traits; BRCA cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.97e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg18357645 chr12:58087776 OS9 0.43 11.98 0.43 5.86e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs17539620 0.624 rs12665520 chr6:154835273 C/T cg20019720 chr6:154832845 CNKSR3 0.52 10.44 0.38 1.18e-23 Lipoprotein (a) levels; BRCA cis rs6426558 0.537 rs56219094 chr1:227340191 T/C cg10327440 chr1:227177885 CDC42BPA -0.48 -9.48 -0.35 4.92e-20 Neutrophil percentage of white cells; BRCA cis rs798554 0.549 rs1623138 chr7:2899410 A/G cg04166393 chr7:2884313 GNA12 0.48 10.29 0.38 4.52e-23 Height; BRCA cis rs6700896 0.900 rs4459081 chr1:66164327 G/C cg04111102 chr1:66153794 NA -0.36 -8.33 -0.31 5.08e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1059312 0.932 rs11059916 chr12:129287609 C/A cg09035930 chr12:129282057 SLC15A4 0.55 16.11 0.54 2.99e-49 Systemic lupus erythematosus; BRCA trans rs1994135 0.630 rs11052757 chr12:33719879 A/G cg26384229 chr12:38710491 ALG10B 0.61 12.25 0.44 3.92e-31 Resting heart rate; BRCA cis rs2859741 0.967 rs507460 chr1:37493206 C/G cg09363841 chr1:37513479 NA 0.64 16.03 0.54 7.36e-49 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs10267417 0.603 rs1557774 chr7:19908777 A/G cg05791153 chr7:19748676 TWISTNB 0.47 9.05 0.34 1.69e-18 Night sleep phenotypes; BRCA cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg01579765 chr21:45077557 HSF2BP -0.41 -10.56 -0.39 3.89e-24 Mean corpuscular volume; BRCA cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg13010199 chr12:38710504 ALG10B 0.33 7.86 0.3 1.59e-14 Morning vs. evening chronotype; BRCA cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.2 -0.31 1.33e-15 Bipolar disorder; BRCA cis rs10992471 0.603 rs7850528 chr9:95208992 A/G cg14631576 chr9:95140430 CENPP -0.38 -9.02 -0.34 2.19e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs6977660 0.714 rs12666488 chr7:19788403 G/A cg05791153 chr7:19748676 TWISTNB 0.58 10.58 0.39 3.27e-24 Thyroid stimulating hormone; BRCA cis rs12493885 0.818 rs55681005 chr3:153759257 G/T cg17054900 chr3:154042577 DHX36 -0.5 -8.55 -0.32 8.73e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg08280861 chr8:58055591 NA 0.61 9.32 0.35 1.81e-19 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.500 rs34418276 chr12:34535976 C/T cg06521331 chr12:34319734 NA -0.55 -9.69 -0.36 7.96e-21 Morning vs. evening chronotype; BRCA cis rs9914988 0.943 rs7215000 chr17:27088436 C/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.87 -0.33 7.23e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg02733842 chr7:1102375 C7orf50 0.69 12.88 0.45 6.39e-34 Bronchopulmonary dysplasia; BRCA cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg01579765 chr21:45077557 HSF2BP -0.43 -11.63 -0.42 1.75e-28 Mean corpuscular volume; BRCA cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg00745463 chr17:30367425 LRRC37B -0.53 -8.91 -0.33 5.36e-18 Hip circumference adjusted for BMI; BRCA cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg11366901 chr6:160182831 ACAT2 0.81 15.79 0.53 1.1e-47 Age-related macular degeneration (geographic atrophy); BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg03609598 chr5:56110824 MAP3K1 -0.46 -8.07 -0.3 3.55e-15 Initial pursuit acceleration; BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.22 -0.44 5.38e-31 Alzheimer's disease; BRCA cis rs950169 0.519 rs7237 chr15:85186577 C/T cg11189052 chr15:85197271 WDR73 0.39 7.88 0.3 1.37e-14 Schizophrenia; BRCA cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.2 -0.34 5.17e-19 Bipolar disorder; BRCA cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg23711669 chr6:146136114 FBXO30 0.66 13.82 0.48 3.22e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg03354898 chr7:1950403 MAD1L1 0.44 9.34 0.35 1.59e-19 Bipolar disorder and schizophrenia; BRCA cis rs12367572 0.965 rs7979717 chr12:45242272 A/T cg04608330 chr12:45269318 NELL2 -0.58 -12.62 -0.45 9.49e-33 Gut microbiome composition (summer); BRCA cis rs11971779 0.666 rs7786851 chr7:139007020 C/G cg07862535 chr7:139043722 LUC7L2 -0.4 -8.97 -0.33 3.25e-18 Diisocyanate-induced asthma; BRCA cis rs7119038 0.509 rs11216961 chr11:118580338 C/G cg19308663 chr11:118741387 NA 0.37 8.23 0.31 1.02e-15 Sjögren's syndrome; BRCA cis rs7246657 0.943 rs1035479 chr19:37893300 G/T cg14683738 chr19:37701593 ZNF585B -0.44 -7.97 -0.3 7.07e-15 Coronary artery calcification; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg04025307 chr7:1156635 C7orf50 0.59 9.31 0.35 2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs637571 0.522 rs606978 chr11:65711517 A/C cg17712092 chr4:129076599 LARP1B 0.62 14.62 0.5 5.91e-42 Eosinophil percentage of white cells; BRCA cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg09184832 chr6:79620586 NA -0.52 -11.32 -0.41 3.45e-27 Intelligence (multi-trait analysis); BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.53 10.49 0.38 7.1e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2637266 0.935 rs2583048 chr10:78404507 C/G cg18941641 chr10:78392320 NA 0.35 7.98 0.3 6.89e-15 Pulmonary function; BRCA cis rs61990749 0.597 rs7147516 chr14:78153980 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.63 -9.65 -0.36 1.13e-20 Fibroblast growth factor basic levels; BRCA cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg27446573 chr6:127587934 RNF146 0.81 18.44 0.59 3.29e-61 Breast cancer; BRCA cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.59 13.88 0.48 1.69e-38 Systemic lupus erythematosus; BRCA trans rs783540 0.967 rs783529 chr15:83267981 A/G cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.29 -0.31 6.65e-16 Schizophrenia; BRCA cis rs2425143 0.822 rs6060677 chr20:34499368 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.58 7.91 0.3 1.16e-14 Blood protein levels; BRCA cis rs881375 0.678 rs3761846 chr9:123689597 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.48 0.32 1.52e-16 Rheumatoid arthritis; BRCA cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.26 -0.44 3.51e-31 Bipolar disorder; BRCA cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg09184832 chr6:79620586 NA -0.41 -7.94 -0.3 9.17e-15 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg06115741 chr20:33292138 TP53INP2 -0.38 -8.46 -0.32 1.78e-16 Glomerular filtration rate (creatinine); BRCA cis rs4595586 0.756 rs7137139 chr12:39364013 C/T cg26384229 chr12:38710491 ALG10B 0.38 8.43 0.32 2.3e-16 Morning vs. evening chronotype; BRCA cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg02466173 chr16:30829666 NA -0.44 -9.86 -0.36 1.9e-21 Dementia with Lewy bodies; BRCA cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg07636037 chr3:49044803 WDR6 -0.51 -8.28 -0.31 7.43e-16 Menarche (age at onset); BRCA cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.88e-15 Breast cancer; BRCA cis rs2288073 0.801 rs72797831 chr2:24366829 G/A cg26838691 chr2:24397539 C2orf84 -0.45 -8.18 -0.31 1.59e-15 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs12586317 0.547 rs112138868 chr14:35444385 C/T cg16230307 chr14:35515116 FAM177A1 0.74 15.5 0.52 3.27e-46 Psoriasis; BRCA cis rs4363385 0.818 rs472076 chr1:153013742 G/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.19 -0.34 5.43e-19 Inflammatory skin disease; BRCA cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.52 -0.32 1.18e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg03709012 chr19:19516395 GATAD2A 0.71 15.53 0.52 2.1e-46 Tonsillectomy; BRCA trans rs2562456 0.917 rs2681392 chr19:21695987 T/G cg25042112 chr7:64838748 ZNF92 0.46 8.63 0.32 4.86e-17 Pain; BRCA cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg21770322 chr7:97807741 LMTK2 0.43 11.49 0.41 6.49e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs12200560 0.505 rs211165 chr6:97068520 A/T cg06623918 chr6:96969491 KIAA0776 0.51 11.93 0.43 9.45e-30 Coronary heart disease; BRCA cis rs6598955 0.627 rs12143920 chr1:26575834 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg20701182 chr2:24300061 SF3B14 0.7 10.31 0.38 3.56e-23 Lymphocyte counts; BRCA cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12379764 chr21:47803548 PCNT -0.55 -10.91 -0.4 1.5e-25 Testicular germ cell tumor; BRCA cis rs7903847 0.642 rs11189172 chr10:99135215 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.06 -0.3 3.86e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg00531865 chr16:30841666 NA -0.38 -9.05 -0.34 1.67e-18 Dementia with Lewy bodies; BRCA cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg21918786 chr6:109611834 NA -0.49 -14.14 -0.49 1.03e-39 Reticulocyte fraction of red cells; BRCA cis rs4363385 0.747 rs1415971 chr1:152965779 T/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.38 -0.35 1.14e-19 Inflammatory skin disease; BRCA cis rs34779708 0.931 rs7908573 chr10:35309513 T/C cg03585969 chr10:35415529 CREM 0.55 11.39 0.41 1.72e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7833986 0.501 rs2668007 chr8:56944111 C/T cg26371346 chr8:56986568 SNORD54;RPS20 0.51 8.47 0.32 1.74e-16 Height; BRCA cis rs7927771 0.770 rs11039203 chr11:47384597 A/G cg20307385 chr11:47447363 PSMC3 -0.41 -8.68 -0.32 3.32e-17 Subjective well-being; BRCA cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg26384229 chr12:38710491 ALG10B 0.67 15.29 0.52 3.21e-45 Bladder cancer; BRCA cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.913 rs273916 chr5:131659830 C/A cg12564285 chr5:131593104 PDLIM4 0.34 7.86 0.3 1.7e-14 Acylcarnitine levels; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg00166722 chr3:10149974 C3orf24 -0.63 -11.22 -0.41 8.43e-27 Alzheimer's disease; BRCA cis rs2012796 0.743 rs8020575 chr14:81859521 G/A cg02996355 chr14:81879375 NA 0.52 10.38 0.38 1.98e-23 Night sleep phenotypes; BRCA cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.94 0.3 9.23e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs920590 0.758 rs1907799 chr8:19664668 A/G cg03894339 chr8:19674705 INTS10 -0.45 -8.89 -0.33 6.11e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.69 -0.5 2.76e-42 Hemoglobin concentration; BRCA cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg12935359 chr14:103987150 CKB -0.59 -14.08 -0.49 2.02e-39 Body mass index; BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.87 0.36 1.77e-21 Tonsillectomy; BRCA cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -8.62 -0.32 5.23e-17 Schizophrenia; BRCA cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.37 0.31 3.59e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649465 0.905 rs3757504 chr7:123391750 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.13 -0.31 2.21e-15 Migraine; BRCA trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg27661571 chr11:113659931 NA -0.8 -12.01 -0.43 4.07e-30 Hip circumference adjusted for BMI; BRCA cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg26408565 chr15:76604113 ETFA -0.47 -9.94 -0.37 9.32e-22 Blood metabolite levels; BRCA cis rs897080 0.515 rs1067336 chr2:44625876 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.65 0.32 4.16e-17 Height; BRCA cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg08807101 chr21:30365312 RNF160 0.74 19.4 0.61 3.03e-66 Dental caries; BRCA cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.66 15.54 0.52 1.89e-46 Chronic sinus infection; BRCA cis rs698813 0.642 rs1837702 chr2:44492444 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.44 0.32 2.05e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs7246657 0.943 rs9676967 chr19:37928089 G/C cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA trans rs7615952 0.641 rs2365019 chr3:125808135 T/C cg07211511 chr3:129823064 LOC729375 -0.62 -10.82 -0.39 3.47e-25 Blood pressure (smoking interaction); BRCA cis rs7833986 1.000 rs4263734 chr8:57099931 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.27 0.31 8.08e-16 Height; BRCA cis rs3733585 0.699 rs6834893 chr4:9959123 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.92 0.37 1.14e-21 Tonsillectomy; BRCA cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.22 -0.58 4.79e-60 Extrinsic epigenetic age acceleration; BRCA cis rs2797160 1.000 rs1739377 chr6:126012236 T/C cg05901451 chr6:126070800 HEY2 0.4 9.64 0.36 1.24e-20 Endometrial cancer; BRCA cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg21132104 chr15:45694354 SPATA5L1 0.75 16.54 0.55 2.01e-51 Homoarginine levels; BRCA cis rs763121 0.524 rs760645 chr22:39032270 C/T cg06022373 chr22:39101656 GTPBP1 0.5 10.77 0.39 5.82e-25 Menopause (age at onset); BRCA cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.53 -0.52 2.1e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs13190036 0.551 rs4976639 chr5:176550301 A/C cg06733329 chr5:176740039 MXD3 -0.4 -8.07 -0.3 3.56e-15 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg18305652 chr10:134549665 INPP5A 0.49 12.04 0.43 3.15e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.32 0.61 7.31e-66 Alzheimer's disease; BRCA cis rs6138458 0.717 rs2179732 chr20:25000446 A/T cg26195577 chr20:24973756 C20orf3 0.7 17.7 0.57 2.38e-57 Blood protein levels; BRCA cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg01579765 chr21:45077557 HSF2BP -0.37 -9.8 -0.36 3.36e-21 Mean corpuscular volume; BRCA cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.3 0.31 6.38e-16 Schizophrenia; BRCA trans rs1973993 0.561 rs61334931 chr1:96988776 T/A cg10631902 chr5:14652156 NA -0.41 -10.06 -0.37 3.36e-22 Weight; BRCA cis rs7523050 0.643 rs34801874 chr1:109404382 C/T cg08274380 chr1:109419600 GPSM2 0.98 14.02 0.49 3.82e-39 Fat distribution (HIV); BRCA cis rs561341 0.943 rs508566 chr17:30289861 G/C cg23018236 chr17:30244563 NA -0.61 -9.92 -0.37 1.12e-21 Hip circumference adjusted for BMI; BRCA cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 8.81 0.33 1.13e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs11674184 0.714 rs16857668 chr2:11723110 G/A cg07314298 chr2:11723111 GREB1 -0.83 -20.63 -0.63 6.98e-73 Endometriosis; BRCA cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.29 -0.31 6.74e-16 Bipolar disorder; BRCA trans rs208520 0.690 rs74707865 chr6:66717352 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 20.36 0.63 1.98e-71 Exhaled nitric oxide output; BRCA cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs4742903 0.935 rs1507513 chr9:106973857 A/G cg14250997 chr9:106856677 SMC2 0.3 9.3 0.35 2.15e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs1355223 0.545 rs7106831 chr11:34879542 T/C cg11058730 chr11:34937778 PDHX;APIP -0.49 -9.62 -0.36 1.54e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs738322 1.000 rs133012 chr22:38570721 G/A cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.58e-27 Extrinsic epigenetic age acceleration; BRCA cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg06671706 chr8:8559999 CLDN23 0.45 8.77 0.33 1.57e-17 Obesity-related traits; BRCA cis rs17270561 0.609 rs9393665 chr6:25744284 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs11690935 0.851 rs6731562 chr2:172798262 T/C cg13550731 chr2:172543902 DYNC1I2 -0.75 -22.26 -0.66 1.02e-81 Schizophrenia; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.63 11.66 0.42 1.3e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.5 -10.99 -0.4 7.31e-26 IgG glycosylation; BRCA cis rs11634851 0.844 rs12917526 chr15:81025457 G/C cg03950166 chr15:80988613 FAM108C1 -0.33 -7.9 -0.3 1.25e-14 Systolic blood pressure; BRCA trans rs2736345 0.755 rs2736340 chr8:11343973 C/T cg06636001 chr8:8085503 FLJ10661 0.46 7.88 0.3 1.43e-14 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg10011062 chr15:43941034 CATSPER2 -0.53 -7.98 -0.3 6.85e-15 Lung cancer in ever smokers; BRCA cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg08997352 chr12:9597637 DDX12 -0.5 -9.91 -0.37 1.19e-21 Breast size; BRCA cis rs9902453 0.780 rs3115093 chr17:28039755 G/A cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 14.26 0.49 3.02e-40 Coffee consumption (cups per day); BRCA cis rs910316 1.000 rs175436 chr14:75608683 C/G cg11812906 chr14:75593930 NEK9 -0.6 -13.62 -0.47 2.82e-37 Height; BRCA cis rs11098499 0.644 rs10012252 chr4:120559139 T/C cg09307838 chr4:120376055 NA 0.59 12.48 0.44 3.76e-32 Corneal astigmatism; BRCA cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg00531865 chr16:30841666 NA -0.4 -9.88 -0.36 1.62e-21 Dementia with Lewy bodies; BRCA cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg06238570 chr21:40685208 BRWD1 -0.47 -9.26 -0.34 3.09e-19 Cognitive function; BRCA cis rs13082711 0.595 rs1445114 chr3:27345489 C/A cg02860705 chr3:27208620 NA 0.76 13.86 0.48 2.22e-38 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA trans rs1973993 0.691 rs11165623 chr1:96893000 G/A cg10631902 chr5:14652156 NA 0.55 18.31 0.59 1.66e-60 Weight; BRCA cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg19052272 chr2:3704530 ALLC 0.41 9.89 0.36 1.53e-21 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs1499614 1.000 rs2659903 chr7:66180931 G/A cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg18230493 chr5:56204884 C5orf35 0.62 13.23 0.46 1.64e-35 Initial pursuit acceleration; BRCA cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg11952622 chr19:58962976 ZNF324B 0.51 10.52 0.38 5.47e-24 Uric acid clearance; BRCA cis rs7172677 0.737 rs6495154 chr15:75437262 G/C cg10253484 chr15:75165896 SCAMP2 -0.45 -8.31 -0.31 5.6e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA trans rs11976180 1.000 rs1919949 chr7:143767723 G/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.43 -7.95 -0.3 8.47e-15 Obesity-related traits; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.42 -0.44 7.37e-32 Alzheimer's disease; BRCA trans rs2832077 0.943 rs2832100 chr21:30175628 A/C cg14791747 chr16:20752902 THUMPD1 0.39 9.19 0.34 5.45e-19 Cognitive test performance; BRCA cis rs17376456 0.877 rs13170509 chr5:93378564 T/C cg21475434 chr5:93447410 FAM172A 0.7 8.65 0.32 4.16e-17 Diabetic retinopathy; BRCA cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg22601191 chr20:60968625 CABLES2 0.43 10.48 0.38 8.1e-24 Colorectal cancer; BRCA cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg19508488 chr2:152266495 RIF1 0.51 10.48 0.38 7.94e-24 Lung cancer; BRCA cis rs4566357 0.615 rs10178098 chr2:227914425 C/T cg11843606 chr2:227700838 RHBDD1 -0.41 -9.26 -0.34 3.12e-19 Coronary artery disease; BRCA trans rs11098499 0.710 rs4145952 chr4:120155806 C/A cg25214090 chr10:38739885 LOC399744 0.41 9.28 0.34 2.54e-19 Corneal astigmatism; BRCA cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg03709012 chr19:19516395 GATAD2A -0.76 -16.69 -0.55 3.68e-52 Tonsillectomy; BRCA cis rs1949733 0.523 rs16842563 chr4:8545146 C/T cg13073564 chr4:8508604 NA 0.33 8.33 0.31 5.03e-16 Response to antineoplastic agents; BRCA cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.64 -0.5 4.53e-42 Chronic sinus infection; BRCA cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg27165867 chr14:105738592 BRF1 -0.36 -8.37 -0.31 3.53e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs7707921 0.767 rs226196 chr5:81576965 C/A cg15871215 chr5:81402204 ATG10 0.35 8.02 0.3 5.16e-15 Breast cancer; BRCA cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg13010199 chr12:38710504 ALG10B 0.35 8.22 0.31 1.12e-15 Morning vs. evening chronotype; BRCA cis rs9914988 0.832 rs9903248 chr17:27127439 G/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs875971 0.545 rs316324 chr7:65610614 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.99 -0.37 6.44e-22 Aortic root size; BRCA cis rs4363385 0.747 rs4845506 chr1:152968407 G/A cg24667326 chr1:152973720 SPRR3 -0.36 -9.89 -0.36 1.54e-21 Inflammatory skin disease; BRCA cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg11764359 chr7:65958608 NA 0.65 11.67 0.42 1.12e-28 Aortic root size; BRCA cis rs6547741 1.000 rs13026621 chr2:27807624 G/A cg27432699 chr2:27873401 GPN1 0.45 9.66 0.36 1.06e-20 Oral cavity cancer; BRCA cis rs6120849 0.754 rs6119560 chr20:33606977 G/C cg24642439 chr20:33292090 TP53INP2 0.6 10.3 0.38 4.11e-23 Protein C levels; BRCA cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg22105103 chr4:187893119 NA 0.37 11.37 0.41 2.09e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg17143192 chr8:8559678 CLDN23 0.52 9.93 0.37 1.04e-21 Obesity-related traits; BRCA trans rs6479891 1.000 rs9414786 chr10:65044322 T/A cg14819942 chr15:35414228 NA -0.35 -8.57 -0.32 7.85e-17 Arthritis (juvenile idiopathic); BRCA cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.62 10.3 0.38 4.09e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg16584290 chr5:462447 EXOC3 0.54 15.14 0.51 1.72e-44 Cystic fibrosis severity; BRCA cis rs2180341 0.842 rs9372860 chr6:127546605 G/A cg27446573 chr6:127587934 RNF146 0.8 15.52 0.52 2.37e-46 Breast cancer; BRCA cis rs2120243 0.874 rs9868133 chr3:157151461 G/C cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.49 0.35 4.32e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg15934090 chr1:100435551 SLC35A3 0.35 8.06 0.3 3.67e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg24690094 chr11:67383802 NA 0.53 11.4 0.41 1.63e-27 Mean corpuscular volume; BRCA cis rs698833 0.926 rs1067394 chr2:44638123 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.77 0.39 5.71e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2011503 1.000 rs11671253 chr19:19604206 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.43e-36 High light scatter reticulocyte count; BRCA cis rs9814567 0.964 rs6805388 chr3:134173534 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -7.91 -0.3 1.1e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs61931739 0.517 rs10844727 chr12:34017435 C/T cg13010199 chr12:38710504 ALG10B 0.39 7.87 0.3 1.47e-14 Morning vs. evening chronotype; BRCA trans rs61931739 0.534 rs10844729 chr12:34022919 A/G cg26384229 chr12:38710491 ALG10B 0.65 13.76 0.48 6.33e-38 Morning vs. evening chronotype; BRCA cis rs701145 0.938 rs355752 chr3:153970796 A/G cg17054900 chr3:154042577 DHX36 0.67 11.71 0.42 8.15e-29 Coronary artery disease; BRCA trans rs9747201 1.000 rs9747201 chr17:80177852 A/C cg07393940 chr7:158741817 NA 0.51 10.01 0.37 5.26e-22 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.79 18.96 0.6 6.08e-64 Multiple sclerosis; BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg22535103 chr8:58192502 C8orf71 -0.52 -8.91 -0.33 5.21e-18 Developmental language disorder (linguistic errors); BRCA cis rs589448 1.000 rs589448 chr12:69752200 A/G cg20891283 chr12:69753455 YEATS4 0.84 28.1 0.74 9.91e-114 Cerebrospinal fluid biomarker levels; BRCA trans rs783540 0.500 rs783541 chr15:83255061 T/C cg18393722 chr15:85113863 UBE2QP1 -0.34 -8.67 -0.32 3.65e-17 Schizophrenia; BRCA cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg02659138 chr7:134003124 SLC35B4 0.32 9.78 0.36 3.74e-21 Mean platelet volume; BRCA cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg11752832 chr7:134001865 SLC35B4 0.52 13.55 0.47 6.19e-37 Mean platelet volume; BRCA cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg00152838 chr16:24741724 TNRC6A -0.35 -7.97 -0.3 7.2e-15 Intelligence (multi-trait analysis); BRCA cis rs11955398 0.585 rs9654363 chr5:60033232 C/T cg02684056 chr5:59996105 DEPDC1B -0.38 -8.98 -0.33 3.11e-18 Intelligence (multi-trait analysis); BRCA cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.1 0.46 6.97e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs757110 0.770 rs11024268 chr11:17387982 A/G cg15432903 chr11:17409602 KCNJ11 0.71 15.48 0.52 3.81e-46 Type 2 diabetes; BRCA cis rs2032447 0.610 rs189911 chr6:25965942 A/G cg03264133 chr6:25882463 NA -0.52 -11.03 -0.4 5.04e-26 Intelligence (multi-trait analysis); BRCA trans rs629535 0.734 rs542288 chr8:70057149 G/T cg21567404 chr3:27674614 NA -0.98 -21.35 -0.65 9.76e-77 Dupuytren's disease; BRCA cis rs13315871 1.000 rs9819072 chr3:58353647 A/C cg20936604 chr3:58311152 NA -0.62 -7.96 -0.3 8.01e-15 Cholesterol, total; BRCA cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -9.55 -0.35 2.83e-20 Personality dimensions; BRCA cis rs9815354 0.855 rs73071261 chr3:42003369 C/A cg03022575 chr3:42003672 ULK4 0.74 10.27 0.38 5.43e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs1003719 0.708 rs3787788 chr21:38502804 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs921968 0.541 rs647990 chr2:219441428 T/C cg10223061 chr2:219282414 VIL1 -0.27 -8.1 -0.31 2.71e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs11874712 1.000 rs1800640 chr18:43671400 A/G cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.1 0.31 2.72e-15 Migraine - clinic-based; BRCA cis rs829883 0.724 rs11109507 chr12:98904160 C/T cg25150519 chr12:98850993 NA 0.52 9.64 0.36 1.22e-20 Colorectal adenoma (advanced); BRCA cis rs7940866 0.740 rs2162060 chr11:130830763 A/G cg12179176 chr11:130786555 SNX19 0.59 13.23 0.46 1.7000000000000001e-35 Schizophrenia; BRCA cis rs11711311 1.000 rs2603792 chr3:113509187 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.32 8.34 0.31 4.41e-16 IgG glycosylation; BRCA trans rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05039488 chr6:79577232 IRAK1BP1 0.51 12.04 0.43 3.26e-30 Brugada syndrome; BRCA cis rs9788682 0.706 rs924840 chr15:78731808 A/T cg24631222 chr15:78858424 CHRNA5 0.5 9.91 0.37 1.21e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs1832871 0.672 rs9457363 chr6:158777515 C/T cg07215822 chr6:158701037 NA -0.49 -7.87 -0.3 1.47e-14 Height; BRCA trans rs9291683 0.609 rs36084205 chr4:10028678 A/C cg26043149 chr18:55253948 FECH 0.41 8.91 0.33 5.1e-18 Bone mineral density; BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg21782813 chr7:2030301 MAD1L1 0.39 10.14 0.37 1.61e-22 Bipolar disorder and schizophrenia; BRCA cis rs2841233 0.681 rs2582558 chr14:105347488 A/G cg01147727 chr14:105363015 KIAA0284 0.32 7.9 0.3 1.22e-14 IgG glycosylation; BRCA cis rs9420 0.961 rs71484461 chr11:57488890 G/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.43 -0.44 6.13e-32 Schizophrenia; BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11644478 chr21:40555479 PSMG1 -0.68 -15.33 -0.52 2.16e-45 Cognitive function; BRCA trans rs4596713 0.538 rs1416738 chr9:71787927 C/T cg16512924 chr15:28394682 HERC2 0.45 10.56 0.39 3.97e-24 Headache; BRCA cis rs1538970 0.962 rs4660849 chr1:45819872 A/G cg05343316 chr1:45956843 TESK2 -0.56 -11.61 -0.42 2.1e-28 Platelet count; BRCA cis rs754466 0.580 rs10824571 chr10:79531931 G/A cg17075019 chr10:79541650 NA -0.83 -20.15 -0.62 2.91e-70 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg10560079 chr2:191398806 TMEM194B 0.39 8.42 0.32 2.39e-16 Pulse pressure; BRCA cis rs11249608 0.744 rs4701025 chr5:178444474 G/A cg21905437 chr5:178450457 ZNF879 -0.45 -9.27 -0.34 2.76e-19 Pubertal anthropometrics; BRCA cis rs11250464 0.804 rs11250463 chr10:1406228 T/C cg08668359 chr10:1443807 ADARB2 0.46 8.97 0.33 3.27e-18 Radiation response; BRCA cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg06970220 chr1:156163860 SLC25A44 0.38 9.4 0.35 9.68e-20 Testicular germ cell tumor; BRCA cis rs1997103 0.911 rs6949931 chr7:55391081 T/C cg17469321 chr7:55412551 NA 0.5 9.35 0.35 1.49e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg07148914 chr20:33460835 GGT7 0.44 9.64 0.36 1.27e-20 Height; BRCA cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg22875332 chr1:76189707 ACADM 0.69 14.93 0.51 1.77e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11809207 0.523 rs7087 chr1:26496651 T/C cg00147160 chr1:26503991 CNKSR1 0.28 9.24 0.34 3.71e-19 Height; BRCA cis rs6121246 0.559 rs6060922 chr20:30333909 C/T cg21427119 chr20:30132790 HM13 -0.35 -8.04 -0.3 4.42e-15 Mean corpuscular hemoglobin; BRCA cis rs2066819 1.000 rs2306693 chr12:56680531 T/C cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg02659138 chr7:134003124 SLC35B4 0.36 10.0 0.37 5.73e-22 Mean platelet volume; BRCA cis rs11098499 1.000 rs13435802 chr4:120177960 A/T cg09307838 chr4:120376055 NA -0.6 -11.96 -0.43 7.06e-30 Corneal astigmatism; BRCA cis rs400736 0.930 rs442862 chr1:8079494 T/C cg25007680 chr1:8021821 PARK7 0.48 12.05 0.43 2.87e-30 Response to antidepressants and depression; BRCA cis rs9790314 0.967 rs460165 chr3:161087710 G/A cg04691961 chr3:161091175 C3orf57 -0.63 -16.31 -0.54 2.99e-50 Morning vs. evening chronotype; BRCA cis rs6964587 0.869 rs6946764 chr7:91539003 A/G cg17063962 chr7:91808500 NA -0.51 -11.93 -0.43 9.32e-30 Breast cancer; BRCA cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg08885076 chr2:99613938 TSGA10 -0.6 -13.44 -0.47 1.88e-36 Chronic sinus infection; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg27170947 chr2:26402098 FAM59B 0.97 17.18 0.56 1.18e-54 Gut microbiome composition (summer); BRCA cis rs9517320 0.534 rs9554477 chr13:99160379 C/T cg07423050 chr13:99094983 FARP1 -0.42 -10.01 -0.37 5.39e-22 Longevity; BRCA trans rs11098499 0.863 rs13140409 chr4:120503460 A/G cg25214090 chr10:38739885 LOC399744 0.54 11.89 0.43 1.43e-29 Corneal astigmatism; BRCA cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.07 0.43 2.39e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7523050 0.730 rs11102650 chr1:109464228 C/G cg08274380 chr1:109419600 GPSM2 0.97 14.17 0.49 8.24e-40 Fat distribution (HIV); BRCA cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg22875332 chr1:76189707 ACADM -0.47 -9.04 -0.34 1.86e-18 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4363385 0.747 rs1933383 chr1:152963468 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.27 -0.34 2.87e-19 Inflammatory skin disease; BRCA trans rs6089829 0.962 rs6089825 chr20:61668447 C/T cg17470723 chr8:74884337 TCEB1 0.4 8.74 0.33 2.06e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs754466 0.651 rs10824583 chr10:79619402 C/T cg17075019 chr10:79541650 NA 0.71 16.94 0.56 2.01e-53 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs11098499 0.863 rs10018280 chr4:120478139 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.13 0.31 2.29e-15 Corneal astigmatism; BRCA cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.72 -15.93 -0.53 2.37e-48 Hip circumference adjusted for BMI; BRCA cis rs10078 0.898 rs2241598 chr5:438564 C/T cg08916839 chr5:415575 AHRR -0.51 -9.26 -0.34 3.06e-19 Fat distribution (HIV); BRCA cis rs9287719 0.967 rs10454738 chr2:10742049 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.81e-15 Prostate cancer; BRCA cis rs4948102 0.691 rs4470984 chr7:56033558 A/G cg09872392 chr7:56161020 PHKG1 -0.4 -9.0 -0.34 2.55e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs11051970 0.636 rs2733705 chr12:32561564 T/C cg24626660 chr12:32551988 NA 0.31 9.26 0.34 2.98e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg10523679 chr1:76189770 ACADM -0.46 -8.79 -0.33 1.39e-17 Daytime sleep phenotypes; BRCA cis rs7267979 0.934 rs6037085 chr20:25305202 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.6 -0.35 1.84e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs854765 0.547 rs4072739 chr17:17884660 G/A cg04398451 chr17:18023971 MYO15A -0.71 -15.42 -0.52 7.44e-46 Total body bone mineral density; BRCA cis rs9768139 0.658 rs73746486 chr7:158113191 A/G cg24154853 chr7:158122151 PTPRN2 0.34 8.05 0.3 4.16e-15 Calcium levels; BRCA cis rs67460515 0.563 rs11922957 chr3:160828865 A/C cg03342759 chr3:160939853 NMD3 -0.71 -14.47 -0.5 2.82e-41 Parkinson's disease; BRCA trans rs3812049 0.784 rs1560637 chr5:127448066 A/C cg16011800 chr17:1958478 HIC1 -0.55 -8.95 -0.33 3.76e-18 Lymphocyte counts;Red cell distribution width; BRCA cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg02079420 chr8:82753780 SNX16 -0.31 -8.46 -0.32 1.77e-16 Diastolic blood pressure; BRCA cis rs3815700 1.000 rs7248845 chr19:33096718 T/C cg02997394 chr19:33096574 ANKRD27 0.7 12.01 0.43 4.13e-30 Eosinophilic esophagitis; BRCA cis rs16910800 0.731 rs1871953 chr11:23192677 G/A cg20040320 chr11:23191996 NA -0.59 -9.84 -0.36 2.34e-21 Cancer; BRCA trans rs4596713 0.507 rs1339546 chr9:71790297 G/A cg16512924 chr15:28394682 HERC2 0.45 10.73 0.39 7.99e-25 Headache; BRCA cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.4 8.65 0.32 4.05e-17 Cognitive ability; BRCA cis rs2204008 0.720 rs11180923 chr12:38255172 A/T cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.88e-18 Bladder cancer; BRCA cis rs8016982 0.963 rs2099108 chr14:81675420 C/G cg01989461 chr14:81687754 GTF2A1 0.52 11.19 0.4 1.11e-26 Schizophrenia; BRCA cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg18478394 chr8:109455254 TTC35 0.29 8.28 0.31 7.19e-16 Dupuytren's disease; BRCA cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg11764359 chr7:65958608 NA 0.62 13.46 0.47 1.5e-36 Aortic root size; BRCA cis rs4664304 0.772 rs12692572 chr2:160743793 G/A cg01092293 chr2:160761427 LY75 0.37 8.83 0.33 9.81e-18 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6815814 0.861 rs11936050 chr4:38789524 C/T cg06935464 chr4:38784597 TLR10 0.5 9.97 0.37 7.37e-22 Breast cancer; BRCA cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg26384229 chr12:38710491 ALG10B 0.77 17.86 0.58 3.6e-58 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs11229555 0.645 rs10896785 chr11:58233395 G/A cg15696309 chr11:58395628 NA -0.52 -10.81 -0.39 4.11e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12986413 1.000 rs4807208 chr19:2170205 A/C cg09261902 chr19:2140048 AP3D1 0.39 10.21 0.37 8.69e-23 Height; BRCA cis rs6558530 0.653 rs6984632 chr8:1700434 G/A cg19131313 chr8:1704013 NA -0.41 -8.06 -0.3 3.84e-15 Systolic blood pressure; BRCA trans rs9291683 0.588 rs35099040 chr4:10018839 T/C cg26043149 chr18:55253948 FECH 0.39 8.44 0.32 2.08e-16 Bone mineral density; BRCA cis rs6433895 0.883 rs4432412 chr2:182069079 C/G cg00481216 chr2:181971175 NA 0.38 8.49 0.32 1.49e-16 Lymphocyte counts; BRCA cis rs1865760 1.000 rs2071299 chr6:25914801 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 11.32 0.41 3.23e-27 Height; BRCA cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg03676636 chr4:99064102 C4orf37 0.24 8.27 0.31 7.91e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs2070488 0.804 rs1870914 chr3:38494220 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.63 16.57 0.55 1.51e-51 Electrocardiographic conduction measures; BRCA cis rs11711311 0.955 rs12630791 chr3:113387717 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.33 -8.27 -0.31 7.81e-16 IgG glycosylation; BRCA cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.09 0.37 2.6e-22 Calcium levels; BRCA cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg26384229 chr12:38710491 ALG10B -0.55 -13.6 -0.47 3.6e-37 Morning vs. evening chronotype; BRCA trans rs9929218 0.508 rs6499194 chr16:68744100 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 29.32 0.76 2.17e-120 Colorectal cancer; BRCA cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg03161606 chr19:29218774 NA 0.46 8.11 0.31 2.56e-15 Methadone dose in opioid dependence; BRCA cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg22906224 chr7:99728672 NA 0.46 8.72 0.33 2.31e-17 Coronary artery disease; BRCA cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg10523679 chr1:76189770 ACADM -0.5 -9.61 -0.36 1.58e-20 Daytime sleep phenotypes; BRCA cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg21427119 chr20:30132790 HM13 -0.42 -8.92 -0.33 4.92e-18 Mean corpuscular hemoglobin; BRCA cis rs7568458 0.684 rs1048739 chr2:85764968 T/G cg02493740 chr2:85810744 VAMP5 -0.53 -11.07 -0.4 3.46e-26 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2637030 0.515 rs381374 chr5:52927813 A/G cg06476337 chr5:52856530 NDUFS4 0.38 8.82 0.33 1.09e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs428668 0.523 rs6898671 chr5:150677643 A/T cg14086364 chr5:150678334 SLC36A3 0.53 14.54 0.5 1.34e-41 Skin aging (microtopography measurement); BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26314531 chr2:26401878 FAM59B -0.62 -10.9 -0.4 1.7e-25 Gut microbiome composition (summer); BRCA trans rs4714291 0.832 rs761798 chr6:40087514 C/T cg02267698 chr19:7991119 CTXN1 0.47 9.68 0.36 8.95e-21 Strep throat; BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg17971929 chr21:40555470 PSMG1 0.74 15.95 0.53 1.78e-48 Cognitive function; BRCA cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg11266682 chr4:10021025 SLC2A9 0.41 10.82 0.39 3.72e-25 Bone mineral density; BRCA cis rs9467773 1.000 rs6925895 chr6:26572165 G/T cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 6.01e-21 Intelligence (multi-trait analysis); BRCA trans rs2270927 0.510 rs246814 chr5:75599208 C/T cg13563193 chr19:33072644 PDCD5 0.92 10.65 0.39 1.77e-24 Mean corpuscular volume; BRCA cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg01689657 chr7:91764605 CYP51A1 0.23 8.16 0.31 1.72e-15 Breast cancer; BRCA trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg23505145 chr19:12996616 KLF1 0.56 12.79 0.45 1.66e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs9287719 0.934 rs12692418 chr2:10745870 T/C cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs57908212 1 rs57908212 chr19:2161321 T/C cg09261902 chr19:2140048 AP3D1 0.41 10.62 0.39 2.28e-24 Red blood cell count;Hemoglobin concentration;Hematocrit; BRCA cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.7 11.66 0.42 1.29e-28 Lung function (FEV1/FVC); BRCA cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.29 0.31 6.66e-16 Cognitive ability; BRCA cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg13319975 chr6:146136371 FBXO30 0.41 9.26 0.34 3.15e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg18876405 chr7:65276391 NA 0.44 8.91 0.33 5.4e-18 Corneal structure; BRCA cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.07 0.3 3.54e-15 Aortic root size; BRCA cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg03213289 chr20:61660250 NA 0.63 16.57 0.55 1.44e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs1113500 0.933 rs11185256 chr1:108633957 C/T cg06207961 chr1:108661230 NA 0.46 11.28 0.41 5.1e-27 Growth-regulated protein alpha levels; BRCA cis rs4919087 1.000 rs10786327 chr10:99071408 C/T cg25902810 chr10:99078978 FRAT1 0.52 11.67 0.42 1.17e-28 Monocyte count; BRCA cis rs11098499 0.863 rs6833334 chr4:120504227 C/T cg09307838 chr4:120376055 NA 0.69 13.8 0.48 4.33e-38 Corneal astigmatism; BRCA cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg13271783 chr10:134563150 INPP5A -0.45 -9.56 -0.35 2.52e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3772130 0.583 rs9819530 chr3:121387784 T/G cg20356878 chr3:121714668 ILDR1 0.38 8.62 0.32 5.06e-17 Cognitive performance; BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA cis rs6740322 0.895 rs9309098 chr2:43554972 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.67 12.31 0.44 2.12e-31 Coronary artery disease; BRCA cis rs2204008 0.580 rs1315373 chr12:38179114 T/G cg26384229 chr12:38710491 ALG10B -0.45 -10.15 -0.37 1.53e-22 Bladder cancer; BRCA cis rs9309473 0.607 rs6546824 chr2:73587331 G/A cg20560298 chr2:73613845 ALMS1 -0.42 -10.78 -0.39 5.45e-25 Metabolite levels; BRCA cis rs7246657 0.765 rs10402455 chr19:37728707 G/A cg23950597 chr19:37808831 NA -0.72 -11.47 -0.41 8.03e-28 Coronary artery calcification; BRCA cis rs6430585 0.583 rs78364332 chr2:136640101 T/C cg07169764 chr2:136633963 MCM6 1.3 29.42 0.76 5.9e-121 Corneal structure; BRCA cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 7.94 0.3 9.22e-15 Mean platelet volume; BRCA cis rs7927592 0.956 rs7106259 chr11:68298512 T/G cg20283391 chr11:68216788 NA -0.44 -8.97 -0.33 3.35e-18 Total body bone mineral density; BRCA cis rs3806843 0.933 rs2879087 chr5:140188575 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs546131 0.820 rs744841 chr11:34857667 G/A cg11058730 chr11:34937778 PDHX;APIP 0.46 8.88 0.33 6.66e-18 Lung disease severity in cystic fibrosis; BRCA cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg18016565 chr1:150552671 MCL1 0.35 8.42 0.32 2.54e-16 Tonsillectomy; BRCA cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg13770153 chr20:60521292 NA -0.42 -9.43 -0.35 7.61e-20 Body mass index; BRCA cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs1546505 chr4:120241224 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.43e-28 Corneal astigmatism; BRCA cis rs10752881 0.652 rs10911262 chr1:183114956 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.44 0.55 6.21e-51 Colorectal cancer; BRCA cis rs559928 0.606 rs56311067 chr11:63931607 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.56 0.42 3.32e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs477692 0.789 rs507900 chr10:131398144 A/G cg24747557 chr10:131355152 MGMT 0.36 8.98 0.33 2.89e-18 Response to temozolomide; BRCA cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 8.85e-19 Bipolar disorder; BRCA cis rs735396 0.770 rs2464196 chr12:121435427 G/A cg02403541 chr12:121454288 C12orf43 0.64 12.18 0.43 7.81e-31 N-glycan levels; BRCA cis rs10883723 0.810 rs10883729 chr10:104273943 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.41 0.59 4.72e-61 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg11584989 chr19:19387371 SF4 -0.66 -14.28 -0.49 2.4e-40 Bipolar disorder; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.72e-16 Total body bone mineral density; BRCA cis rs514406 0.505 rs374662 chr1:53164549 C/A cg08859206 chr1:53392774 SCP2 -0.41 -8.7 -0.33 2.7e-17 Monocyte count; BRCA trans rs4689592 0.503 rs11937667 chr4:7057037 C/G cg07817883 chr1:32538562 TMEM39B 0.5 8.17 0.31 1.62e-15 Monocyte percentage of white cells; BRCA cis rs4713118 0.868 rs9468220 chr6:27732976 A/G cg20933634 chr6:27740509 NA -0.45 -8.51 -0.32 1.27e-16 Parkinson's disease; BRCA cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs2797160 1.000 rs1739371 chr6:126011291 G/A cg05901451 chr6:126070800 HEY2 0.39 9.53 0.35 3.34e-20 Endometrial cancer; BRCA cis rs3820928 0.967 rs4675113 chr2:227766339 G/A cg11843606 chr2:227700838 RHBDD1 -0.39 -8.63 -0.32 4.82e-17 Pulmonary function; BRCA cis rs4919087 0.810 rs10736115 chr10:99031685 A/G cg25902810 chr10:99078978 FRAT1 0.41 9.04 0.34 1.86e-18 Monocyte count; BRCA cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.41 -0.44 8.14e-32 Developmental language disorder (linguistic errors); BRCA cis rs4302748 0.862 rs73335286 chr7:36184728 C/T cg24442661 chr7:36192818 EEPD1 0.48 8.81 0.33 1.2e-17 Platelet count; BRCA cis rs1003719 0.679 rs2246285 chr21:38582431 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.41 -0.5 5.89e-41 Eye color traits; BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg08470875 chr2:26401718 FAM59B -0.53 -8.21 -0.31 1.24e-15 Gut microbiome composition (summer); BRCA cis rs7927771 0.832 rs7105851 chr11:47383275 T/C cg20307385 chr11:47447363 PSMC3 0.41 8.7 0.33 2.87e-17 Subjective well-being; BRCA cis rs11105298 0.891 rs4842662 chr12:89933446 T/C cg00757033 chr12:89920650 WDR51B 0.52 10.52 0.38 5.8e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs4363385 0.818 rs1890285 chr1:153015396 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.57 -0.32 7.58e-17 Inflammatory skin disease; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg21782813 chr7:2030301 MAD1L1 0.43 12.31 0.44 2.06e-31 Bipolar disorder and schizophrenia; BRCA cis rs775227 0.574 rs35765657 chr3:113078384 C/T cg18753928 chr3:113234510 CCDC52 -0.55 -9.19 -0.34 5.28e-19 Dental caries; BRCA cis rs11190604 0.767 rs10786590 chr10:102164604 T/C cg07080220 chr10:102295463 HIF1AN 0.5 10.59 0.39 3.07e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7582180 0.629 rs6731549 chr2:100939937 T/G cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg06212747 chr3:49208901 KLHDC8B 0.48 9.9 0.36 1.38e-21 Parkinson's disease; BRCA cis rs9473147 0.543 rs9473126 chr6:47481833 C/G cg12968598 chr6:47444699 CD2AP 0.46 9.86 0.36 1.85e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs9811920 0.683 rs10936003 chr3:99667565 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -11.16 -0.4 1.52e-26 Axial length; BRCA cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg18230493 chr5:56204884 C5orf35 -0.43 -8.88 -0.33 6.55e-18 Coronary artery disease; BRCA cis rs9868809 0.649 rs3733086 chr3:48699519 C/T cg00383909 chr3:49044727 WDR6 0.64 10.54 0.38 4.75e-24 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.67 -0.39 1.46e-24 Menarche (age at onset); BRCA cis rs2637266 0.935 rs2583052 chr10:78403288 C/G cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg08045932 chr20:61659980 NA 0.5 10.99 0.4 7.5e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs2832077 0.943 rs11701777 chr21:30155828 T/C cg24692254 chr21:30365293 RNF160 -0.45 -8.04 -0.3 4.47e-15 Cognitive test performance; BRCA cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.3 -0.38 4.09e-23 Psoriasis; BRCA cis rs11190604 1.000 rs79831012 chr10:102237059 T/C cg07080220 chr10:102295463 HIF1AN 0.48 11.1 0.4 2.65e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg17971929 chr21:40555470 PSMG1 -0.48 -10.57 -0.39 3.65e-24 Menarche (age at onset); BRCA trans rs12517041 1.000 rs10052994 chr5:23292784 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.0 -0.3 5.78e-15 Calcium levels; BRCA cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9420 0.528 rs34052104 chr11:57384519 A/C cg19752551 chr11:57585705 CTNND1 -0.42 -9.63 -0.36 1.41e-20 Schizophrenia; BRCA cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg01579765 chr21:45077557 HSF2BP -0.43 -11.33 -0.41 2.93e-27 Mean corpuscular volume; BRCA cis rs12210905 0.688 rs114843651 chr6:27449611 A/G cg08851530 chr6:28072375 NA 0.82 7.99 0.3 6.52e-15 Hip circumference adjusted for BMI; BRCA cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg04756594 chr16:24857601 SLC5A11 0.54 12.16 0.43 9.53e-31 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg08885076 chr2:99613938 TSGA10 0.42 9.81 0.36 3.08e-21 Chronic sinus infection; BRCA cis rs4664304 0.739 rs2162500 chr2:160708645 C/G cg14819504 chr2:160761413 LY75 0.34 8.43 0.32 2.35e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9790314 1.000 rs336579 chr3:161086610 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.76 -0.5 1.22e-42 Morning vs. evening chronotype; BRCA cis rs7647973 0.593 rs58339610 chr3:49845006 T/A cg03060546 chr3:49711283 APEH -0.6 -10.48 -0.38 7.88e-24 Menarche (age at onset); BRCA cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -9.21 -0.34 4.7e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg01528321 chr10:82214614 TSPAN14 0.63 13.97 0.48 6.43e-39 Post bronchodilator FEV1; BRCA cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11644478 chr21:40555479 PSMG1 -0.52 -10.93 -0.4 1.36e-25 Menarche (age at onset); BRCA cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.76 -0.42 4.94e-29 Colorectal cancer; BRCA cis rs34779708 0.733 rs60553075 chr10:35542462 T/A cg03585969 chr10:35415529 CREM 0.45 9.18 0.34 6.03e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg00339695 chr16:24857497 SLC5A11 -0.52 -11.18 -0.4 1.24e-26 Intelligence (multi-trait analysis); BRCA cis rs1941023 0.503 rs10792269 chr11:60117126 C/T cg08716584 chr11:60157161 MS4A7 -0.42 -9.82 -0.36 2.72e-21 Congenital heart disease (maternal effect); BRCA cis rs514406 0.708 rs536621 chr1:53309097 A/G cg25767906 chr1:53392781 SCP2 -0.46 -10.28 -0.38 4.66e-23 Monocyte count; BRCA cis rs490234 0.627 rs4838276 chr9:128364901 A/G cg14078157 chr9:128172775 NA 0.44 9.84 0.36 2.25e-21 Mean arterial pressure; BRCA cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.02 0.43 3.78e-30 Multiple sclerosis; BRCA cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg19748678 chr4:122722346 EXOSC9 0.74 15.96 0.53 1.71e-48 Type 2 diabetes; BRCA cis rs3125734 0.633 rs6479804 chr10:64048327 T/C cg19640130 chr10:64028056 RTKN2 -0.32 -8.91 -0.33 5.37e-18 Rheumatoid arthritis; BRCA cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg22676075 chr6:135203613 NA -0.6 -12.96 -0.46 2.74e-34 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9880211 0.752 rs9881831 chr3:136389718 T/C cg21827317 chr3:136751795 NA -0.45 -7.97 -0.3 7.3e-15 Body mass index;Height; BRCA cis rs7267979 0.966 rs6037083 chr20:25290543 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.72 -0.36 6.45e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3799977 0.531 rs62436031 chr6:44722203 A/G cg25276700 chr6:44698697 NA 0.36 8.29 0.31 6.81e-16 Attention deficit hyperactivity disorder; BRCA cis rs7301826 1.000 rs4619189 chr12:131313797 A/G cg11011512 chr12:131303247 STX2 0.42 10.4 0.38 1.62e-23 Plasma plasminogen activator levels; BRCA cis rs13046373 0.508 rs1012969 chr21:31996108 G/A cg16812893 chr21:31813075 KRTAP15-1 0.37 9.47 0.35 5.23e-20 HDL cholesterol; BRCA cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg18446336 chr7:2847575 GNA12 -0.34 -8.1 -0.31 2.74e-15 Height; BRCA cis rs10044254 0.641 rs2937074 chr5:15751645 G/A cg07238450 chr5:15720153 FBXL7 -0.38 -8.03 -0.3 4.54e-15 Asthma (corticosteroid response); BRCA cis rs11051970 0.879 rs2651379 chr12:32581778 A/G cg24626660 chr12:32551988 NA 0.28 7.98 0.3 7.03e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs3125734 0.633 rs10740068 chr10:63982254 A/C cg19640130 chr10:64028056 RTKN2 -0.31 -9.05 -0.34 1.64e-18 Rheumatoid arthritis; BRCA cis rs9287719 0.624 rs6740245 chr2:10760902 T/C cg00105475 chr2:10696890 NA 0.41 8.99 0.33 2.85e-18 Prostate cancer; BRCA cis rs4595586 0.545 rs9669705 chr12:39374459 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg04034577 chr2:241836375 C2orf54 -0.57 -13.94 -0.48 9.76e-39 Urinary metabolites; BRCA trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs11971779 0.680 rs1133067 chr7:139053069 G/T cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg00339695 chr16:24857497 SLC5A11 0.51 11.09 0.4 2.88e-26 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg15556689 chr8:8085844 FLJ10661 0.49 13.76 0.48 6.43e-38 Mood instability; BRCA cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg25358565 chr5:93447407 FAM172A 1.15 18.67 0.59 2.15e-62 Diabetic retinopathy; BRCA cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.53 -14.16 -0.49 8.87e-40 Colorectal cancer; BRCA cis rs514406 0.668 rs520281 chr1:53365235 G/C cg25767906 chr1:53392781 SCP2 -0.48 -10.67 -0.39 1.44e-24 Monocyte count; BRCA cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg02466173 chr16:30829666 NA -0.44 -9.79 -0.36 3.39e-21 Dementia with Lewy bodies; BRCA cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08704250 chr15:31115839 NA 0.34 8.77 0.33 1.6e-17 Huntington's disease progression; BRCA cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg23711669 chr6:146136114 FBXO30 0.73 16.88 0.56 3.75e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.54 -0.32 9.93e-17 Monocyte percentage of white cells; BRCA cis rs6426558 0.502 rs2813965 chr1:227445733 A/G cg10327440 chr1:227177885 CDC42BPA 0.52 10.31 0.38 3.75e-23 Neutrophil percentage of white cells; BRCA cis rs2294693 0.945 rs9369255 chr6:40989503 T/C cg14769373 chr6:40998127 UNC5CL -0.39 -7.83 -0.3 2.06e-14 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs7011049 1.000 rs72648403 chr8:53854848 T/C cg26025543 chr8:53854495 NA 0.55 9.49 0.35 4.66e-20 Systolic blood pressure; BRCA cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.7 -0.33 2.83e-17 Total body bone mineral density; BRCA cis rs61931739 0.500 rs3934517 chr12:34451396 T/C cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.8e-23 Morning vs. evening chronotype; BRCA cis rs1420338 0.967 rs4720151 chr7:34160523 G/A cg01275685 chr7:34179230 BMPER -0.45 -9.25 -0.34 3.36e-19 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9325144 0.600 rs12424410 chr12:38758035 A/T cg26384229 chr12:38710491 ALG10B -0.51 -12.16 -0.43 9.46e-31 Morning vs. evening chronotype; BRCA cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg24549020 chr5:56110836 MAP3K1 -0.4 -8.36 -0.31 4.01e-16 Initial pursuit acceleration; BRCA cis rs4820294 0.669 rs1894532 chr22:38059750 T/C cg21798802 chr22:38057573 PDXP 0.31 8.41 0.32 2.78e-16 Fat distribution (HIV); BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg00814883 chr7:100076585 TSC22D4 -0.54 -11.63 -0.42 1.77e-28 Platelet count; BRCA cis rs7927771 0.524 rs12362318 chr11:47682671 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.54 0.35 3e-20 Subjective well-being; BRCA cis rs8177253 0.555 rs4481157 chr3:133464684 G/A cg01448562 chr3:133502909 NA -0.39 -9.13 -0.34 8.62e-19 Iron status biomarkers; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg22920501 chr2:26401640 FAM59B -0.87 -16.6 -0.55 9.68e-52 Gut microbiome composition (summer); BRCA cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.26 -0.31 8.25e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg10523679 chr1:76189770 ACADM -0.49 -9.52 -0.35 3.41e-20 Daytime sleep phenotypes; BRCA cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg13902645 chr11:5959945 NA 0.6 13.77 0.48 5.93e-38 DNA methylation (variation); BRCA cis rs1048238 0.506 rs7525608 chr1:16141901 A/G cg16109817 chr1:16162209 FLJ37453 -0.29 -8.19 -0.31 1.46e-15 Systolic blood pressure; BRCA cis rs6500395 1.000 rs9924078 chr16:48557918 A/C cg04672837 chr16:48644449 N4BP1 -0.42 -9.55 -0.35 2.61e-20 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11578532 chr1:161008127 TSTD1 0.3 9.49 0.35 4.66e-20 Granulocyte percentage of myeloid white cells; BRCA cis rs9462846 1.000 rs56158882 chr6:42860740 T/G cg02353165 chr6:42928485 GNMT 0.49 8.64 0.32 4.47e-17 Blood protein levels; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg24101359 chr6:42928495 GNMT 0.54 12.57 0.45 1.5e-32 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg23205692 chr1:25664452 TMEM50A -0.41 -10.01 -0.37 5.24e-22 Erythrocyte sedimentation rate; BRCA cis rs9318086 0.935 rs9652080 chr13:24435426 A/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.29 -8.31 -0.31 5.74e-16 Myopia (pathological); BRCA cis rs17095355 1.000 rs752584 chr10:111682934 C/G cg00817464 chr10:111662876 XPNPEP1 -0.43 -9.1 -0.34 1.12e-18 Biliary atresia; BRCA trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg03929089 chr4:120376271 NA -0.65 -12.83 -0.45 1.06e-33 Coronary artery disease; BRCA trans rs75804782 0.641 rs72983861 chr2:239326126 G/A cg01134436 chr17:81009848 B3GNTL1 0.76 9.58 0.35 2.02e-20 Morning vs. evening chronotype;Chronotype; BRCA cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg10792982 chr14:105748885 BRF1 0.47 10.94 0.4 1.14e-25 Mean platelet volume;Platelet distribution width; BRCA cis rs2243480 1.000 rs35046236 chr7:65408613 T/C cg18252515 chr7:66147081 NA -0.84 -12.12 -0.43 1.34e-30 Diabetic kidney disease; BRCA cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg11584989 chr19:19387371 SF4 -0.66 -14.28 -0.49 2.4e-40 Bipolar disorder; BRCA cis rs12618769 0.656 rs3769735 chr2:99092302 C/T cg10123293 chr2:99228465 UNC50 0.41 8.51 0.32 1.28e-16 Bipolar disorder; BRCA cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg26061582 chr7:22766209 IL6 0.44 9.91 0.36 1.24e-21 Lung cancer; BRCA cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg12219531 chr12:120966889 COQ5 0.53 11.63 0.42 1.71e-28 High light scatter reticulocyte count; BRCA cis rs10431058 0.708 rs651300 chr11:107488577 A/G cg18204760 chr11:107461044 ELMOD1;LOC643923 -0.38 -8.27 -0.31 7.68e-16 Common traits (Other); BRCA cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg15017067 chr4:17643749 FAM184B -0.29 -8.64 -0.32 4.35e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13095912 0.785 rs34619288 chr3:185331678 G/C cg11274856 chr3:185301563 NA 0.52 12.4 0.44 8.66e-32 Systolic blood pressure; BRCA cis rs2882667 0.690 rs10045605 chr5:138272147 T/C cg04439458 chr5:138467593 SIL1 -0.35 -8.41 -0.32 2.62e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4919694 1.000 rs7099987 chr10:104807926 C/T cg04362960 chr10:104952993 NT5C2 0.94 14.43 0.5 4.38e-41 Arsenic metabolism; BRCA cis rs4730250 0.554 rs76257331 chr7:106916279 G/A cg02696742 chr7:106810147 HBP1 -0.49 -8.01 -0.3 5.32e-15 Osteoarthritis; BRCA cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg17747265 chr1:1875780 NA 0.37 9.24 0.34 3.68e-19 Body mass index; BRCA cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg13319975 chr6:146136371 FBXO30 0.41 9.31 0.35 1.98e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs5758659 0.652 rs133326 chr22:42406885 G/A cg15557168 chr22:42548783 NA -0.31 -8.47 -0.32 1.62e-16 Cognitive function; BRCA cis rs9682041 0.696 rs10936626 chr3:170095019 G/A cg11886554 chr3:170076028 SKIL 0.51 10.16 0.37 1.41e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs9790314 0.967 rs7623206 chr3:160971518 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.08 -0.49 2.01e-39 Morning vs. evening chronotype; BRCA cis rs7666738 0.606 rs6852813 chr4:99084671 G/A cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 6.87e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs514406 0.929 rs554301 chr1:53321948 A/T cg08859206 chr1:53392774 SCP2 0.51 11.2 0.41 1.04e-26 Monocyte count; BRCA cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg26031613 chr14:104095156 KLC1 -0.43 -8.61 -0.32 5.69e-17 Schizophrenia; BRCA cis rs17376456 0.877 rs12374488 chr5:93481407 A/G cg21475434 chr5:93447410 FAM172A 0.7 8.86 0.33 7.58e-18 Diabetic retinopathy; BRCA cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.05 -0.3 4.07e-15 Blood pressure (smoking interaction); BRCA cis rs7809950 1.000 rs10234355 chr7:107086517 T/G cg23024343 chr7:107201750 COG5 -0.4 -9.28 -0.34 2.65e-19 Coronary artery disease; BRCA cis rs4713118 0.662 rs9468271 chr6:28024570 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.45e-16 Parkinson's disease; BRCA cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg21782813 chr7:2030301 MAD1L1 0.35 9.08 0.34 1.31e-18 Bipolar disorder and schizophrenia; BRCA cis rs1372520 0.684 rs2619341 chr4:90741773 A/G cg15133208 chr4:90757351 SNCA -0.39 -7.83 -0.3 2.04e-14 Neuroticism; BRCA cis rs9790314 0.718 rs1599383 chr3:160829820 T/C cg03342759 chr3:160939853 NMD3 -0.5 -10.01 -0.37 5.24e-22 Morning vs. evening chronotype; BRCA cis rs72781680 0.679 rs718138 chr2:23976324 G/A cg08917208 chr2:24149416 ATAD2B 0.62 9.83 0.36 2.52e-21 Lymphocyte counts; BRCA cis rs61931739 0.500 rs28692887 chr12:34457075 G/A cg06521331 chr12:34319734 NA -0.56 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs8077889 0.672 rs3785810 chr17:41850689 C/G cg26893861 chr17:41843967 DUSP3 0.91 23.25 0.68 3.97e-87 Triglycerides; BRCA trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.63 0.32 4.74e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7819412 0.811 rs2409691 chr8:10943276 C/T cg21775007 chr8:11205619 TDH -0.43 -8.93 -0.33 4.39e-18 Triglycerides; BRCA cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg05283184 chr6:79620031 NA -0.34 -7.9 -0.3 1.2e-14 Intelligence (multi-trait analysis); BRCA cis rs877282 1.000 rs71494928 chr10:769134 A/G cg17470449 chr10:769945 NA 0.49 8.54 0.32 9.71e-17 Uric acid levels; BRCA cis rs9790314 0.905 rs7611367 chr3:161003182 A/G cg03342759 chr3:160939853 NMD3 0.6 12.63 0.45 8.72e-33 Morning vs. evening chronotype; BRCA cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg24558204 chr6:135376177 HBS1L 0.42 10.7 0.39 1.12e-24 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg13256891 chr4:100009986 ADH5 0.54 10.16 0.37 1.43e-22 Smoking initiation; BRCA cis rs4595586 0.505 rs6580897 chr12:39372254 A/G cg26384229 chr12:38710491 ALG10B 0.41 9.22 0.34 4.35e-19 Morning vs. evening chronotype; BRCA cis rs6500602 0.702 rs6500606 chr16:4502514 A/G cg08645402 chr16:4508243 NA -0.48 -12.81 -0.45 1.32e-33 Schizophrenia; BRCA cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.0 0.34 2.55e-18 Lymphocyte counts; BRCA cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15541040 chr2:3486749 NA -0.46 -10.21 -0.37 8.86e-23 Neurofibrillary tangles; BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg11814155 chr7:99998594 ZCWPW1 0.47 8.38 0.31 3.41e-16 Platelet count; BRCA cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg21518248 chr2:162101506 NA 0.71 17.53 0.57 1.77e-56 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs9818758 0.556 rs9814987 chr3:49207849 T/C cg00383909 chr3:49044727 WDR6 0.74 12.9 0.45 5.43e-34 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg09913183 chr17:42254507 C17orf65;ASB16 -0.44 -9.07 -0.34 1.43e-18 Total body bone mineral density; BRCA cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA trans rs911555 0.617 rs7156036 chr14:103908142 A/G cg17675199 chr6:35436792 RPL10A -0.3 -8.03 -0.3 4.8e-15 Intelligence (multi-trait analysis); BRCA cis rs6142102 0.961 rs6120519 chr20:32688113 A/G cg24642439 chr20:33292090 TP53INP2 0.4 7.97 0.3 7.48e-15 Skin pigmentation; BRCA cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg23625390 chr15:77176239 SCAPER 0.39 9.59 0.35 1.94e-20 Blood metabolite levels; BRCA cis rs10924970 0.967 rs12739707 chr1:235466564 C/G cg26050004 chr1:235667680 B3GALNT2 0.31 7.83 0.3 2.09e-14 Asthma; BRCA cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg13319975 chr6:146136371 FBXO30 -0.55 -12.06 -0.43 2.47e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs7020830 0.823 rs7019699 chr9:37125081 C/A cg14294708 chr9:37120828 ZCCHC7 1.19 43.18 0.86 1.27e-191 Schizophrenia; BRCA cis rs6540559 0.673 rs4556361 chr1:210019654 C/G cg22029157 chr1:209979665 IRF6 -0.43 -8.19 -0.31 1.42e-15 Cleft lip with or without cleft palate; BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.66 14.28 0.49 2.28e-40 Lymphocyte counts; BRCA cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg23583168 chr7:148888333 NA -0.84 -19.64 -0.61 1.44e-67 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11608355 0.515 rs2287192 chr12:109931594 C/T cg05360138 chr12:110035743 NA 0.73 13.41 0.47 2.64e-36 Neuroticism; BRCA cis rs7561273 0.586 rs7580772 chr2:24357657 T/C cg04809136 chr2:24300158 SF3B14 -0.4 -8.97 -0.33 3.37e-18 Quantitative traits; BRCA cis rs10751667 0.643 rs10794343 chr11:925493 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.77 0.53 1.38e-47 Alzheimer's disease (late onset); BRCA cis rs2624839 0.704 rs13064381 chr3:50233317 C/T cg14019146 chr3:50243930 SLC38A3 -0.66 -16.44 -0.55 6.59e-51 Intelligence (multi-trait analysis); BRCA cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg10295955 chr4:187884368 NA -0.99 -31.87 -0.78 3.73e-134 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg21573476 chr21:45109991 RRP1B -0.43 -11.67 -0.42 1.13e-28 Mean corpuscular volume; BRCA cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg13256891 chr4:100009986 ADH5 0.54 10.14 0.37 1.65e-22 Alcohol dependence; BRCA cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg21385522 chr1:16154831 NA 0.47 8.5 0.32 1.39e-16 Dilated cardiomyopathy; BRCA cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.83e-24 Motion sickness; BRCA trans rs9325144 0.560 rs11182979 chr12:38642562 C/A cg23762105 chr12:34175262 ALG10 0.34 7.99 0.3 6.54e-15 Morning vs. evening chronotype; BRCA cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg26384229 chr12:38710491 ALG10B 0.66 15.14 0.51 1.78e-44 Bladder cancer; BRCA cis rs9814567 0.963 rs36006513 chr3:134291913 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.78 0.62 2.8e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6912958 0.781 rs2207146 chr6:88180641 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.29 -8.03 -0.3 4.68e-15 Monocyte percentage of white cells; BRCA cis rs12347191 0.500 rs973473 chr9:100620730 T/G cg13688889 chr9:100608707 NA -0.49 -9.96 -0.37 8.33e-22 Orofacial clefts; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.34 -0.31 4.5e-16 Total body bone mineral density; BRCA cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg00071950 chr4:10020882 SLC2A9 -0.5 -11.39 -0.41 1.76e-27 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6121246 0.559 rs10439608 chr20:30258814 T/C cg21427119 chr20:30132790 HM13 -0.35 -7.92 -0.3 1.06e-14 Mean corpuscular hemoglobin; BRCA cis rs616402 0.527 rs589151 chr1:10567711 C/T cg17425144 chr1:10567563 PEX14 0.63 16.63 0.55 6.95e-52 Breast size; BRCA cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg06970220 chr1:156163860 SLC25A44 0.4 9.71 0.36 7.2e-21 Testicular germ cell tumor; BRCA cis rs2625529 0.652 rs2957740 chr15:72307691 A/G cg16672083 chr15:72433130 SENP8 0.69 16.77 0.55 1.32e-52 Red blood cell count; BRCA cis rs877282 0.945 rs17293517 chr10:778770 C/T cg17470449 chr10:769945 NA 0.52 8.8 0.33 1.22e-17 Uric acid levels; BRCA cis rs9790314 0.663 rs61105146 chr3:160651949 T/A cg03342759 chr3:160939853 NMD3 0.44 8.52 0.32 1.18e-16 Morning vs. evening chronotype; BRCA cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 13.73 0.48 8.52e-38 Hip circumference adjusted for BMI; BRCA trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg13010199 chr12:38710504 ALG10B 0.48 9.53 0.35 3.25e-20 Morning vs. evening chronotype; BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.55 0.42 3.81e-28 Tonsillectomy; BRCA cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg02780029 chr10:43622663 RET 0.36 7.98 0.3 6.56e-15 Hirschsprung disease; BRCA cis rs3806843 0.838 rs2262567 chr5:140132134 T/A cg11822812 chr5:140052017 DND1 -0.32 -8.69 -0.33 3.01e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs6582630 0.554 rs7299735 chr12:38450890 A/C cg26384229 chr12:38710491 ALG10B -0.43 -9.87 -0.36 1.75e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg12463550 chr7:65579703 CRCP 0.38 8.21 0.31 1.23e-15 Aortic root size; BRCA cis rs61931739 0.534 rs11053131 chr12:34282109 A/G cg06521331 chr12:34319734 NA -0.67 -14.69 -0.5 2.6e-42 Morning vs. evening chronotype; BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg19346786 chr7:2764209 NA -0.36 -10.56 -0.39 4e-24 Height; BRCA cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg20887711 chr4:1340912 KIAA1530 0.36 8.55 0.32 9.29e-17 Longevity; BRCA cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.98 -0.3 6.79e-15 Bipolar disorder; BRCA trans rs3749237 1.000 rs11130216 chr3:49736172 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.01 0.34 2.3e-18 Resting heart rate; BRCA cis rs3768617 0.510 rs10797846 chr1:183087485 A/T ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA cis rs9653442 0.777 rs6732141 chr2:100743492 G/C cg07810366 chr2:100720526 AFF3 -0.31 -7.9 -0.3 1.2e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs6005807 0.719 rs73430118 chr22:28913950 C/T cg12565055 chr22:29076175 TTC28 0.46 8.45 0.32 1.97e-16 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs208520 1.000 rs12194996 chr6:66973366 G/C cg07460842 chr6:66804631 NA 0.69 11.58 0.42 2.68e-28 Exhaled nitric oxide output; BRCA cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11644478 chr21:40555479 PSMG1 -0.68 -15.46 -0.52 4.87e-46 Cognitive function; BRCA cis rs10782582 0.593 rs4638068 chr1:76161663 G/A cg10523679 chr1:76189770 ACADM -0.47 -9.1 -0.34 1.12e-18 Daytime sleep phenotypes; BRCA cis rs10743315 0.599 rs11044451 chr12:19365798 C/T cg02471346 chr12:19282374 PLEKHA5 -0.55 -9.08 -0.34 1.29e-18 Gut microbiota (bacterial taxa); BRCA cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg22800045 chr5:56110881 MAP3K1 -0.58 -9.93 -0.37 1.04e-21 Initial pursuit acceleration; BRCA cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg04248312 chr19:17393744 ANKLE1 0.93 21.55 0.65 7.33e-78 Systemic lupus erythematosus; BRCA cis rs7246657 0.654 rs10407568 chr19:38123009 A/T cg14683738 chr19:37701593 ZNF585B 0.47 8.12 0.31 2.4e-15 Coronary artery calcification; BRCA cis rs595982 0.527 rs56021835 chr19:49369989 G/A cg15549821 chr19:49342101 PLEKHA4 -0.72 -11.68 -0.42 1.05e-28 Red cell distribution width; BRCA cis rs616402 0.527 rs11121581 chr1:10577740 A/G cg17425144 chr1:10567563 PEX14 0.62 16.4 0.54 1.02e-50 Breast size; BRCA cis rs113835537 0.529 rs11227510 chr11:66281220 T/C cg24851651 chr11:66362959 CCS 0.44 8.29 0.31 6.92e-16 Airway imaging phenotypes; BRCA cis rs13108904 0.901 rs12642410 chr4:1308409 A/G cg00684032 chr4:1343700 KIAA1530 0.41 9.97 0.37 7.22e-22 Obesity-related traits; BRCA cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg17366294 chr4:99064904 C4orf37 0.42 9.81 0.36 2.94e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg05283184 chr6:79620031 NA -0.36 -8.78 -0.33 1.54e-17 Intelligence (multi-trait analysis); BRCA cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12292205 chr6:26970375 C6orf41 0.48 8.03 0.3 4.67e-15 Intelligence (multi-trait analysis); BRCA cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg26818010 chr10:134567672 INPP5A -0.79 -15.89 -0.53 3.58e-48 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs3857536 0.842 rs2188591 chr6:66939511 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs10046574 0.561 rs10226494 chr7:135214412 C/G cg27474649 chr7:135195673 CNOT4 0.61 10.42 0.38 1.35e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg22676075 chr6:135203613 NA 0.44 8.6 0.32 6.06e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.91 0.3 1.15e-14 Parkinson's disease; BRCA cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg25173405 chr17:45401733 C17orf57 -0.51 -10.8 -0.39 4.43e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg23791538 chr6:167370224 RNASET2 -0.42 -10.05 -0.37 3.79e-22 Crohn's disease; BRCA cis rs10751667 0.600 rs11246376 chr11:999622 C/T ch.11.42038R chr11:967971 AP2A2 0.46 13.98 0.48 5.97e-39 Alzheimer's disease (late onset); BRCA cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg16405210 chr4:1374714 KIAA1530 -0.36 -7.83 -0.3 2.02e-14 Obesity-related traits; BRCA cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.19 0.4 1.17e-26 Bipolar disorder; BRCA cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg26818010 chr10:134567672 INPP5A -0.54 -12.47 -0.44 4.05e-32 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg11584989 chr19:19387371 SF4 0.64 13.51 0.47 8.71e-37 Bipolar disorder; BRCA cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg06494592 chr3:125709126 NA -0.53 -8.25 -0.31 9.2e-16 Blood pressure (smoking interaction); BRCA trans rs8073060 0.586 rs225296 chr17:33924847 C/G cg19694781 chr19:47549865 TMEM160 -1.0 -21.66 -0.65 1.96e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7520050 0.966 rs6429582 chr1:46321843 C/T cg24296786 chr1:45957014 TESK2 -0.44 -9.75 -0.36 5.11e-21 Red blood cell count;Reticulocyte count; BRCA cis rs9341808 0.754 rs9352808 chr6:80997342 G/T cg08355045 chr6:80787529 NA 0.35 9.01 0.34 2.36e-18 Sitting height ratio; BRCA cis rs2764208 0.599 rs9368828 chr6:34661449 A/T cg07306190 chr6:34760872 UHRF1BP1 0.26 7.94 0.3 9.21e-15 Systemic lupus erythematosus; BRCA cis rs4891159 0.790 rs660029 chr18:74149668 A/G cg24786174 chr18:74118243 ZNF516 0.8 22.99 0.67 1.06e-85 Longevity; BRCA cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.5e-64 Cognitive function; BRCA trans rs4650994 0.525 rs2493858 chr1:178541210 A/G cg05059571 chr16:84539110 KIAA1609 -0.57 -12.7 -0.45 4.24e-33 HDL cholesterol levels;HDL cholesterol; BRCA cis rs9814567 1.000 rs9985356 chr3:134232920 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.57 18.57 0.59 7.05e-62 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs877282 0.945 rs11253396 chr10:789754 C/T cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs9487051 0.738 rs171272 chr6:109530094 T/C cg21918786 chr6:109611834 NA -0.33 -8.87 -0.33 7.57e-18 Reticulocyte fraction of red cells; BRCA cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08109568 chr15:31115862 NA -0.45 -10.37 -0.38 2.14e-23 Huntington's disease progression; BRCA cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.52 -9.82 -0.36 2.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12997796 0.556 rs13004867 chr2:86982504 C/G cg25203885 chr2:87302643 LOC285074 -0.6 -9.8 -0.36 3.16e-21 Schizophrenia; BRCA cis rs3849570 1.000 rs3849570 chr3:81792112 C/A cg07356753 chr3:81810745 GBE1 -0.47 -11.41 -0.41 1.35e-27 Waist circumference;Body mass index; BRCA cis rs11190604 1.000 rs7090431 chr10:102261753 A/G cg07080220 chr10:102295463 HIF1AN 0.6 14.4 0.5 6.25e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1003719 0.737 rs9974374 chr21:38479885 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.09 0.49 1.88e-39 Eye color traits; BRCA cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg26248373 chr2:1572462 NA -0.62 -14.47 -0.5 2.94e-41 IgG glycosylation; BRCA cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs3815700 0.841 rs10410895 chr19:33093655 T/G cg02997394 chr19:33096574 ANKRD27 0.69 11.52 0.41 4.75e-28 Eosinophilic esophagitis; BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg04944784 chr2:26401820 FAM59B -0.69 -11.43 -0.41 1.14e-27 Gut microbiome composition (summer); BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.81 0.36 2.99e-21 Tonsillectomy; BRCA cis rs10128251 0.650 rs4469789 chr10:5712366 A/G cg24097872 chr10:5724021 NA 0.44 9.95 0.37 8.44e-22 Childhood ear infection; BRCA cis rs12530845 0.673 rs4073627 chr7:135312572 A/G cg23117316 chr7:135346802 PL-5283 0.36 7.85 0.3 1.78e-14 Red blood cell traits; BRCA cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg08917208 chr2:24149416 ATAD2B 0.54 8.43 0.32 2.29e-16 Asthma; BRCA cis rs9399135 0.933 rs7755680 chr6:135294259 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.36 0.44 1.22e-31 Red blood cell count; BRCA cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.5e-64 Cognitive function; BRCA cis rs3857067 0.806 rs4693374 chr4:95086164 A/C cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.15 -0.34 7.51e-19 QT interval; BRCA cis rs1707322 1.000 rs1613296 chr1:46546852 A/C cg03146154 chr1:46216737 IPP -0.42 -9.15 -0.34 7.39e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg07930192 chr7:1003750 NA 0.41 8.7 0.33 2.76e-17 Longevity;Endometriosis; BRCA cis rs2836974 0.897 rs13049280 chr21:40594656 C/G cg11890956 chr21:40555474 PSMG1 1.01 24.99 0.7 1.11e-96 Cognitive function; BRCA cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.43 -9.32 -0.35 1.82e-19 Colorectal cancer; BRCA cis rs17021463 0.902 rs10516950 chr4:95254730 C/T cg11021082 chr4:95130006 SMARCAD1 0.4 9.28 0.34 2.64e-19 Testicular germ cell tumor; BRCA cis rs250677 1.000 rs36069 chr5:148417253 G/C cg18129178 chr5:148520854 ABLIM3 -0.57 -11.69 -0.42 9.61e-29 Breast cancer; BRCA cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg13770153 chr20:60521292 NA -0.45 -10.79 -0.39 4.77e-25 Body mass index; BRCA cis rs2710642 0.962 rs7557501 chr2:63086639 C/T cg17519650 chr2:63277830 OTX1 0.37 8.14 0.31 2.04e-15 LDL cholesterol levels;LDL cholesterol; BRCA cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg02297831 chr4:17616191 MED28 0.36 8.49 0.32 1.41e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg16606324 chr3:10149918 C3orf24 0.49 9.81 0.36 2.97e-21 Alzheimer's disease; BRCA cis rs4290604 0.748 rs12692198 chr2:238057391 C/A cg23555395 chr2:238036564 NA -0.51 -8.36 -0.31 3.94e-16 Asthma; BRCA cis rs2882667 0.690 rs700627 chr5:138119400 A/T cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs208515 0.525 rs4145045 chr6:66678949 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 14.54 0.5 1.32e-41 Exhaled nitric oxide levels; BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg03188948 chr7:1209495 NA 0.86 11.78 0.42 3.91e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6545883 0.895 rs2421192 chr2:61643631 T/C cg15711740 chr2:61764176 XPO1 0.53 13.48 0.47 1.19e-36 Tuberculosis; BRCA cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.15 0.31 1.87e-15 Tonsillectomy; BRCA cis rs9818758 0.556 rs9835439 chr3:49220330 G/C cg00383909 chr3:49044727 WDR6 0.73 12.12 0.43 1.36e-30 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg26384229 chr12:38710491 ALG10B 0.85 22.52 0.67 3.94e-83 Heart rate; BRCA cis rs769267 0.931 rs15622 chr19:19468734 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.59 -0.35 1.96e-20 Tonsillectomy; BRCA cis rs7715806 0.500 rs2291630 chr5:75013356 G/A cg19683494 chr5:74908142 NA 0.53 8.58 0.32 7.25e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 11.34 0.41 2.9e-27 Platelet count; BRCA cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.58 0.42 2.75e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9649465 1.000 rs12537287 chr7:123364747 G/A cg04330084 chr7:123175371 IQUB -0.34 -9.1 -0.34 1.14e-18 Migraine; BRCA cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg16506815 chr2:162101123 NA 0.45 9.59 0.35 1.88e-20 Intelligence (multi-trait analysis); BRCA cis rs17818399 0.547 rs4953400 chr2:46777208 T/A cg02822958 chr2:46747628 ATP6V1E2 0.51 9.36 0.35 1.32e-19 Height; BRCA cis rs3772130 0.923 rs3805127 chr3:121556751 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.05 0.37 3.52e-22 Cognitive performance; BRCA cis rs1577917 0.816 rs9353349 chr6:86707725 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 11.69 0.42 9.61e-29 Response to antipsychotic treatment; BRCA cis rs34172651 0.917 rs200536 chr16:24749203 G/A cg00339695 chr16:24857497 SLC5A11 -0.34 -7.82 -0.3 2.15e-14 Intelligence (multi-trait analysis); BRCA trans rs79976124 0.879 rs17511467 chr6:66627293 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.6 0.39 2.78e-24 Type 2 diabetes; BRCA cis rs1403694 0.695 rs10439971 chr3:186434188 C/T cg12454167 chr3:186435060 KNG1 0.29 7.92 0.3 1.04e-14 Blood protein levels; BRCA cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.02 0.34 2.14e-18 Eosinophil percentage of white cells; BRCA cis rs11229555 0.645 rs11229489 chr11:58244917 A/G cg15696309 chr11:58395628 NA -0.52 -10.72 -0.39 9.29e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs11671005 0.504 rs3794963 chr19:59071051 C/G cg22037779 chr5:139682734 PFDN1 0.54 10.93 0.4 1.34e-25 Mean platelet volume; BRCA cis rs1904096 0.506 rs7697827 chr4:95184748 G/A cg11021082 chr4:95130006 SMARCAD1 -0.39 -8.21 -0.31 1.22e-15 Type 2 diabetes; BRCA cis rs868036 1.000 rs4325504 chr15:68055570 A/G cg08079166 chr15:68083412 MAP2K5 -0.33 -8.71 -0.33 2.52e-17 Restless legs syndrome; BRCA cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg17724175 chr1:150552817 MCL1 0.24 7.8 0.3 2.45e-14 Melanoma; BRCA cis rs1476679 1.000 rs1476679 chr7:100004446 C/T cg19116668 chr7:99932089 PMS2L1 0.48 8.87 0.33 7.34e-18 Alzheimer's disease (late onset); BRCA cis rs7512552 0.809 rs698923 chr1:150379159 G/A cg15654264 chr1:150340011 RPRD2 0.43 9.23 0.34 3.93e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg22307297 chr20:60903441 LAMA5 0.36 9.93 0.37 1.03e-21 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14240646 chr10:27532245 ACBD5 0.64 9.52 0.35 3.43e-20 Breast cancer; BRCA cis rs3768617 0.510 rs6424885 chr1:183066254 T/G ch.1.3577855R chr1:183094577 LAMC1 0.68 18.02 0.58 5.02e-59 Fuchs's corneal dystrophy; BRCA cis rs919433 0.679 rs6708239 chr2:198525084 A/G cg00792783 chr2:198669748 PLCL1 0.39 9.03 0.34 2.08e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2806561 0.929 rs6660880 chr1:23540302 T/C cg19743168 chr1:23544995 NA -0.46 -11.52 -0.41 4.8e-28 Height; BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg24060327 chr5:131705240 SLC22A5 -0.4 -7.85 -0.3 1.82e-14 Acylcarnitine levels; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg21782813 chr7:2030301 MAD1L1 0.32 8.57 0.32 7.59e-17 Bipolar disorder and schizophrenia; BRCA cis rs2625529 0.730 rs2929527 chr15:72282270 T/G cg16672083 chr15:72433130 SENP8 0.66 15.72 0.53 2.5e-47 Red blood cell count; BRCA cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg15103426 chr22:29168792 CCDC117 0.54 12.78 0.45 1.76e-33 Lymphocyte counts; BRCA cis rs7172677 0.501 rs8040061 chr15:75393720 C/A cg14664628 chr15:75095509 CSK 0.4 9.14 0.34 7.89e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6665290 0.545 rs6426584 chr1:227374949 A/T cg10327440 chr1:227177885 CDC42BPA -0.85 -19.71 -0.61 6.75e-68 Myeloid white cell count; BRCA cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11890956 chr21:40555474 PSMG1 0.81 13.24 0.46 1.52e-35 Cognitive function; BRCA cis rs4363385 0.818 rs559236 chr1:153010510 T/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03264133 chr6:25882463 NA 0.54 11.23 0.41 7.69e-27 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg24642439 chr20:33292090 TP53INP2 -0.42 -8.67 -0.32 3.43e-17 Glomerular filtration rate (creatinine); BRCA cis rs11626933 0.959 rs8005973 chr14:90774951 C/T cg14092571 chr14:90743983 NA -0.81 -21.7 -0.65 1.26e-78 Gut microbiota (bacterial taxa); BRCA cis rs9875589 0.509 rs4685062 chr3:14066409 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.95 0.33 3.85e-18 Ovarian reserve; BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 17.75 0.57 1.36e-57 Alzheimer's disease; BRCA cis rs7264396 0.887 rs224360 chr20:34059675 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.41 8.53 0.32 1.03e-16 Total cholesterol levels; BRCA trans rs17685 0.796 rs3757594 chr7:75678644 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -28.07 -0.74 1.43e-113 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs68092024 0.731 rs793480 chr3:99488364 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.56 -0.39 3.85e-24 Cleft lip with or without cleft palate; BRCA trans rs6951245 1.000 rs11766526 chr7:1101433 G/A cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.570 rs10032272 chr4:99095601 T/C cg05340658 chr4:99064831 C4orf37 0.49 10.77 0.39 5.83e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.818 rs2070964 chr1:153004213 C/T cg24667326 chr1:152973720 SPRR3 -0.31 -8.52 -0.32 1.16e-16 Inflammatory skin disease; BRCA cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg08807101 chr21:30365312 RNF160 -0.6 -15.0 -0.51 8.49e-44 Dental caries; BRCA cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -10.11 -0.37 2.21e-22 Body mass index; BRCA cis rs2070433 0.948 rs2839304 chr21:47952650 C/G cg05998816 chr21:47859926 PCNT -0.37 -8.77 -0.33 1.64e-17 Lymphocyte counts; BRCA cis rs694739 0.628 rs645078 chr11:64135298 A/C cg23796481 chr11:64053134 BAD;GPR137 0.5 10.53 0.38 5.17e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs921968 0.565 rs2059717 chr2:219600316 A/T cg02176678 chr2:219576539 TTLL4 -0.41 -10.93 -0.4 1.35e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6931421 1.000 rs6931421 chr6:80880138 A/C cg08355045 chr6:80787529 NA 0.41 9.15 0.34 7.83e-19 Sitting height ratio; BRCA cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg21770322 chr7:97807741 LMTK2 0.44 11.72 0.42 7.34e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg11657440 chr19:46296263 DMWD 0.71 19.22 0.61 2.7e-65 Coronary artery disease; BRCA cis rs4363385 0.647 rs1995308 chr1:153014082 A/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.38 -0.31 3.35e-16 Inflammatory skin disease; BRCA cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg03188948 chr7:1209495 NA -0.52 -9.63 -0.36 1.34e-20 Longevity;Endometriosis; BRCA cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg13628971 chr7:2884303 GNA12 0.38 8.57 0.32 7.68e-17 Height; BRCA cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg04546413 chr19:29218101 NA 0.49 8.47 0.32 1.63e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs1580019 0.961 rs2392056 chr7:32498953 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.53 0.32 1.07e-16 Cognitive ability; BRCA cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs2404602 0.735 rs2957614 chr15:76696635 C/T cg23625390 chr15:77176239 SCAPER 0.54 13.74 0.48 8.09e-38 Blood metabolite levels; BRCA cis rs17253792 0.822 rs79262019 chr14:56092704 A/G cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA trans rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.89 0.3 1.35e-14 Endometrial cancer; BRCA cis rs6120849 0.754 rs3746446 chr20:33574765 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.18 0.37 1.16e-22 Protein C levels; BRCA cis rs151349 1.000 rs108727 chr20:57584890 C/T cg23907860 chr20:57583709 CTSZ 0.45 11.06 0.4 3.92e-26 Platelet distribution width; BRCA cis rs8062405 1.000 rs4788099 chr16:28855727 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.9 0.33 5.77e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg05283184 chr6:79620031 NA -0.43 -11.21 -0.41 9.28e-27 Intelligence (multi-trait analysis); BRCA cis rs244731 0.959 rs6872021 chr5:176610012 G/A cg06060754 chr5:176797920 RGS14 -0.67 -10.3 -0.38 4.09e-23 Urate levels in lean individuals; BRCA cis rs597539 0.652 rs516425 chr11:68715675 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 17.73 0.57 1.61e-57 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs77972916 0.505 rs6719754 chr2:43526386 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -11.05 -0.4 4.32e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs1451375 0.669 rs59086818 chr7:50653830 G/A cg18232548 chr7:50535776 DDC 0.4 9.24 0.34 3.6e-19 Malaria; BRCA cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.47 -0.32 1.74e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs8028182 0.577 rs28693593 chr15:75849776 A/C cg20655648 chr15:75932815 IMP3 0.44 8.7 0.33 2.74e-17 Sudden cardiac arrest; BRCA cis rs9325144 0.577 rs10876008 chr12:39126750 T/C cg26384229 chr12:38710491 ALG10B -0.49 -11.31 -0.41 3.55e-27 Morning vs. evening chronotype; BRCA cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg08999081 chr20:33150536 PIGU 0.45 12.72 0.45 3.46e-33 Glomerular filtration rate (creatinine); BRCA cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.71 -0.39 9.99e-25 Bone mineral density; BRCA cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg18876405 chr7:65276391 NA -0.57 -13.43 -0.47 2.16e-36 Aortic root size; BRCA cis rs10504073 0.584 rs11778863 chr8:49954893 C/T cg00325661 chr8:49890786 NA 0.49 14.07 0.49 2.32e-39 Blood metabolite ratios; BRCA cis rs9487051 0.834 rs351728 chr6:109549099 T/C cg01475377 chr6:109611718 NA -0.41 -9.76 -0.36 4.7e-21 Reticulocyte fraction of red cells; BRCA cis rs8177179 1.000 rs8177179 chr3:133463457 G/A cg24879335 chr3:133465180 TF 0.32 10.89 0.4 1.97e-25 Iron status biomarkers (transferrin levels); BRCA cis rs1371614 0.635 rs12618836 chr2:27137616 A/G cg12368169 chr2:27073192 DPYSL5 0.29 8.55 0.32 9.18e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.46 0.5 3.41e-41 Personality dimensions; BRCA cis rs6835098 1.000 rs28477433 chr4:174085820 T/C cg08422745 chr4:174089978 GALNT7 -0.81 -18.41 -0.59 4.71e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg25036284 chr2:26402008 FAM59B 0.77 10.71 0.39 1.01e-24 Gut microbiome composition (summer); BRCA cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11890956 chr21:40555474 PSMG1 -0.62 -13.9 -0.48 1.43e-38 Menarche (age at onset); BRCA trans rs2197308 0.692 rs1904964 chr12:37933241 T/A cg06521331 chr12:34319734 NA -0.5 -9.26 -0.34 3.16e-19 Morning vs. evening chronotype; BRCA cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg10729496 chr3:10149963 C3orf24 -0.49 -9.24 -0.34 3.62e-19 Alzheimer's disease; BRCA cis rs10992471 0.528 rs1924243 chr9:95224847 C/T cg14631576 chr9:95140430 CENPP -0.35 -8.86 -0.33 8.14e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs765787 0.530 rs3759895 chr15:45543870 G/A cg24006582 chr15:45444508 DUOX1 -0.55 -11.45 -0.41 9.28e-28 Uric acid levels; BRCA cis rs7267979 0.844 rs1555330 chr20:25232097 A/C cg08601574 chr20:25228251 PYGB 0.41 9.62 0.36 1.49e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs765787 0.530 rs11854689 chr15:45516052 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg26384229 chr12:38710491 ALG10B 0.57 13.13 0.46 5.01e-35 Morning vs. evening chronotype; BRCA cis rs10463316 0.817 rs6877498 chr5:150802876 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.59 -0.32 6.42e-17 Metabolite levels (Pyroglutamine); BRCA cis rs9457247 0.534 rs7750593 chr6:167387359 C/G cg23791538 chr6:167370224 RNASET2 0.51 13.06 0.46 9.76e-35 Crohn's disease; BRCA cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg02079420 chr8:82753780 SNX16 0.32 8.64 0.32 4.33e-17 Diastolic blood pressure; BRCA cis rs4891159 0.790 rs77878087 chr18:74116337 G/A cg24786174 chr18:74118243 ZNF516 -0.76 -18.62 -0.59 4e-62 Longevity; BRCA cis rs9297145 0.678 rs62473007 chr7:98749598 G/C cg05967295 chr7:98741636 SMURF1 0.86 16.26 0.54 5.17e-50 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA trans rs61931739 0.612 rs1906137 chr12:33939676 T/A cg26384229 chr12:38710491 ALG10B 0.39 8.8 0.33 1.27e-17 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26314531 chr2:26401878 FAM59B -0.66 -11.2 -0.4 1.08e-26 Gut microbiome composition (summer); BRCA cis rs9296092 0.560 rs17627049 chr6:33537802 G/T cg13560919 chr6:33536144 NA -0.92 -19.27 -0.61 1.44e-65 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1448094 0.512 rs1349063 chr12:86264237 C/T cg19622623 chr12:86230825 RASSF9 -0.35 -9.57 -0.35 2.21e-20 Major depressive disorder; BRCA cis rs10791097 0.694 rs1050071 chr11:130747231 C/G cg12179176 chr11:130786555 SNX19 0.71 16.4 0.54 1.04e-50 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg06636001 chr8:8085503 FLJ10661 -0.63 -12.82 -0.45 1.26e-33 Myopia (pathological); BRCA cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.61 0.42 1.98e-28 Rheumatoid arthritis; BRCA cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg23029597 chr12:123009494 RSRC2 -0.62 -12.62 -0.45 9.4e-33 Body mass index; BRCA cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg24006582 chr15:45444508 DUOX1 0.56 11.23 0.41 8.18e-27 Uric acid levels; BRCA cis rs2580764 0.515 rs4672005 chr2:55246551 C/T cg09592903 chr2:55203963 RTN4 -0.39 -9.87 -0.36 1.73e-21 Mean platelet volume; BRCA cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg00321850 chr1:175162397 KIAA0040 -0.41 -11.37 -0.41 2.11e-27 Alcohol dependence; BRCA cis rs11711311 1.000 rs1073040 chr3:113522123 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.34 8.75 0.33 1.92e-17 IgG glycosylation; BRCA cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg08213375 chr14:104286397 PPP1R13B 0.42 9.05 0.34 1.69e-18 Reticulocyte count; BRCA cis rs4423214 0.840 rs1629220 chr11:71174553 C/T cg05163923 chr11:71159392 DHCR7 -0.58 -11.63 -0.42 1.67e-28 Vitamin D levels; BRCA cis rs11122272 0.735 rs2491412 chr1:231535880 A/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -11.46 -0.41 9.02e-28 Hemoglobin concentration; BRCA cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg16109817 chr1:16162209 FLJ37453 -0.29 -8.16 -0.31 1.84e-15 Systolic blood pressure; BRCA cis rs7927592 0.956 rs7126340 chr11:68257293 C/T cg20283391 chr11:68216788 NA -0.45 -9.3 -0.35 2.17e-19 Total body bone mineral density; BRCA cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.48e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs3809566 0.963 rs4775608 chr15:63331940 A/G cg05507819 chr15:63340323 TPM1 0.42 9.14 0.34 7.97e-19 Platelet count; BRCA trans rs9329221 0.736 rs11249999 chr8:10251265 C/T cg15556689 chr8:8085844 FLJ10661 -0.35 -8.57 -0.32 8.04e-17 Neuroticism; BRCA cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs4363385 0.818 rs10888525 chr1:153000215 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.38 -0.31 3.34e-16 Inflammatory skin disease; BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg14004847 chr7:1930337 MAD1L1 -0.44 -8.84 -0.33 9.29e-18 Bipolar disorder and schizophrenia; BRCA cis rs2204008 0.545 rs1663283 chr12:38132039 G/A cg26384229 chr12:38710491 ALG10B -0.46 -10.56 -0.39 3.73e-24 Bladder cancer; BRCA cis rs36051895 0.623 rs2381215 chr9:5262607 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.37 -0.31 3.61e-16 Pediatric autoimmune diseases; BRCA cis rs6456156 1.000 rs6456156 chr6:167522300 T/C cg07741184 chr6:167504864 NA 0.28 8.39 0.32 3.08e-16 Primary biliary cholangitis; BRCA cis rs9914988 0.943 rs9908881 chr17:27100924 T/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg08514558 chr10:81106712 PPIF 0.36 8.78 0.33 1.55e-17 Height; BRCA cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.23 0.31 1.06e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs992157 1.000 rs992157 chr2:219154781 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.6 -13.78 -0.48 5.11e-38 Colorectal cancer; BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.57 11.48 0.41 7.53e-28 Tonsillectomy; BRCA cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg01262667 chr19:19385393 TM6SF2 -0.42 -10.79 -0.39 4.77e-25 Tonsillectomy; BRCA cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.51 11.19 0.4 1.1e-26 Multiple sclerosis; BRCA cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg08807892 chr2:162101083 NA -0.47 -9.23 -0.34 3.98e-19 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg22907277 chr7:1156413 C7orf50 0.6 9.01 0.34 2.28e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7264396 0.747 rs2425151 chr20:34394541 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.85 0.3 1.73e-14 Total cholesterol levels; BRCA cis rs1190552 0.739 rs1998421 chr14:102979644 C/T cg18135206 chr14:102964638 TECPR2 0.43 8.34 0.31 4.66e-16 Blood protein levels; BRCA cis rs6750795 0.569 rs1667308 chr2:232406344 T/C cg19187155 chr2:232395269 NMUR1 0.69 17.51 0.57 2.19e-56 Height; BRCA cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg11266682 chr4:10021025 SLC2A9 -0.38 -9.66 -0.36 1.04e-20 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9297145 0.761 rs62473015 chr7:98763301 G/A cg05967295 chr7:98741636 SMURF1 0.96 18.17 0.58 8.37e-60 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA trans rs11098499 0.775 rs67281037 chr4:120281157 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.97e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7927771 0.756 rs10742803 chr11:47439938 A/G cg20307385 chr11:47447363 PSMC3 0.41 9.22 0.34 4.13e-19 Subjective well-being; BRCA cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg17366294 chr4:99064904 C4orf37 0.43 9.94 0.37 9.98e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg03923535 chr7:1197113 ZFAND2A 0.46 9.31 0.35 2.04e-19 Longevity;Endometriosis; BRCA cis rs877282 0.583 rs12356155 chr10:823940 C/T cg15764593 chr10:829463 NA -0.65 -10.71 -0.39 1.02e-24 Uric acid levels; BRCA cis rs34779708 0.931 rs12771399 chr10:35452377 C/T cg03585969 chr10:35415529 CREM 0.55 11.15 0.4 1.65e-26 Inflammatory bowel disease;Crohn's disease; BRCA trans rs9325144 0.600 rs1817648 chr12:38733424 C/T cg23762105 chr12:34175262 ALG10 0.37 9.58 0.35 2.16e-20 Morning vs. evening chronotype; BRCA cis rs67460515 0.892 rs73026974 chr3:160963231 A/C cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Parkinson's disease; BRCA cis rs7520050 0.966 rs6668284 chr1:46354510 G/A cg24296786 chr1:45957014 TESK2 0.43 9.73 0.36 5.98e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4853036 1.000 rs3732269 chr2:70046255 G/C cg02498382 chr2:70120550 SNRNP27 -0.49 -8.86 -0.33 7.8e-18 Colorectal or endometrial cancer; BRCA cis rs11984145 1.000 rs73121399 chr7:38870368 T/C cg19327137 chr7:38886074 VPS41 0.5 7.91 0.3 1.15e-14 Cognitive performance; BRCA cis rs73001065 0.551 rs10424702 chr19:19508013 A/G cg03709012 chr19:19516395 GATAD2A 0.99 14.79 0.51 8.7e-43 LDL cholesterol; BRCA cis rs17253792 0.822 rs17685102 chr14:56129214 A/G cg01858014 chr14:56050164 KTN1 -0.74 -9.16 -0.34 7.15e-19 Putamen volume; BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.41 0.44 8.15e-32 Platelet count; BRCA cis rs514406 0.565 rs897732 chr1:53382816 A/C cg27535305 chr1:53392650 SCP2 -0.49 -12.27 -0.44 3.16e-31 Monocyte count; BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg08888203 chr3:10149979 C3orf24 0.55 11.76 0.42 4.89e-29 Alzheimer's disease; BRCA cis rs6450176 0.638 rs1542167 chr5:53305742 T/G ch.5.1024479R chr5:53302184 ARL15 -0.89 -17.27 -0.56 4.13e-55 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg23719950 chr11:63933701 MACROD1 -0.52 -8.31 -0.31 5.61e-16 Mean platelet volume; BRCA cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg17063962 chr7:91808500 NA 0.52 12.38 0.44 1.01e-31 Breast cancer; BRCA cis rs778371 0.723 rs6710294 chr2:233579634 T/C cg08000102 chr2:233561755 GIGYF2 0.85 21.05 0.64 3.79e-75 Schizophrenia; BRCA cis rs870825 0.929 rs2310102 chr4:185595141 C/G cg04058563 chr4:185651563 MLF1IP -0.63 -11.33 -0.41 3.05e-27 Blood protein levels; BRCA cis rs11711311 1.000 rs2242109 chr3:113434100 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.64 0.39 1.83e-24 IgG glycosylation; BRCA cis rs11098499 0.779 rs72918579 chr4:120333222 G/C cg09307838 chr4:120376055 NA 0.77 17.15 0.56 1.63e-54 Corneal astigmatism; BRCA cis rs68170813 0.559 rs80307895 chr7:106907781 T/A cg02696742 chr7:106810147 HBP1 -0.53 -8.63 -0.32 4.99e-17 Coronary artery disease; BRCA cis rs7903847 0.620 rs11189165 chr10:99123457 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.34 -0.31 4.5e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg05340658 chr4:99064831 C4orf37 0.67 16.71 0.55 2.87e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs12478296 1.000 rs4973685 chr2:243019089 A/C cg18898632 chr2:242989856 NA -0.51 -8.56 -0.32 8.62e-17 Obesity-related traits; BRCA cis rs57221529 0.713 rs56328416 chr5:591138 G/A cg09021430 chr5:549028 NA -0.65 -13.68 -0.48 1.54e-37 Lung disease severity in cystic fibrosis; BRCA cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg13877915 chr19:58951672 ZNF132 0.46 10.81 0.39 4.09e-25 Uric acid clearance; BRCA cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg17211192 chr8:82754475 SNX16 -0.56 -11.54 -0.42 4.05e-28 Diastolic blood pressure; BRCA cis rs2243480 1.000 rs60683927 chr7:65394768 T/C cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg21433313 chr16:3507492 NAT15 0.45 10.04 0.37 4.18e-22 Tuberculosis; BRCA cis rs6545883 0.862 rs11691734 chr2:61702466 C/T cg15711740 chr2:61764176 XPO1 -0.52 -13.14 -0.46 4.63e-35 Tuberculosis; BRCA cis rs2742234 0.541 rs7096500 chr10:43712095 C/T cg15436174 chr10:43711423 RASGEF1A 0.53 10.6 0.39 2.76e-24 Hirschsprung disease; BRCA cis rs2070488 0.965 rs6599209 chr3:38558197 A/G cg24069376 chr3:38537580 EXOG -0.42 -11.94 -0.43 8.5e-30 Electrocardiographic conduction measures; BRCA cis rs2171564 0.791 rs4682420 chr3:112440692 C/T cg06685282 chr3:112453648 NA -0.36 -8.73 -0.33 2.15e-17 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 12.68 0.45 5.22e-33 Hip circumference adjusted for BMI; BRCA cis rs1420338 0.967 rs2192874 chr7:34144916 G/A cg01275685 chr7:34179230 BMPER -0.51 -11.46 -0.41 8.84e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24531977 chr5:56204891 C5orf35 -0.87 -19.03 -0.6 2.76e-64 Initial pursuit acceleration; BRCA cis rs6840360 0.571 rs62327271 chr4:152535916 A/G cg22705602 chr4:152727874 NA -0.32 -8.03 -0.3 4.64e-15 Intelligence (multi-trait analysis); BRCA cis rs796364 0.951 rs971232 chr2:200792881 C/T cg23649088 chr2:200775458 C2orf69 0.6 8.85 0.33 8.7e-18 Schizophrenia; BRCA cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg08885076 chr2:99613938 TSGA10 0.58 13.1 0.46 6.64e-35 Chronic sinus infection; BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg00106254 chr7:1943704 MAD1L1 -0.42 -10.14 -0.37 1.61e-22 Bipolar disorder and schizophrenia; BRCA cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg13298116 chr11:62369859 EML3;MTA2 0.59 13.82 0.48 3.46e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7647973 0.626 rs11709734 chr3:49745235 G/A cg03060546 chr3:49711283 APEH 0.6 10.38 0.38 1.97e-23 Menarche (age at onset); BRCA trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.32 8.64 0.32 4.53e-17 Intelligence (multi-trait analysis); BRCA cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.95 0.3 8.75e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs27434 0.583 rs34764 chr5:96155229 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.15e-33 Ankylosing spondylitis; BRCA cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg27129171 chr3:47204927 SETD2 -0.71 -17.01 -0.56 8.42e-54 Colorectal cancer; BRCA cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.89 0.45 6.08e-34 Bipolar disorder; BRCA cis rs9467773 1.000 rs9467796 chr6:26568411 A/G cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.4e-57 Intelligence (multi-trait analysis); BRCA cis rs950027 0.549 rs1719250 chr15:45609773 A/G cg21132104 chr15:45694354 SPATA5L1 0.45 9.58 0.35 2.04e-20 Response to fenofibrate (adiponectin levels); BRCA cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg26031613 chr14:104095156 KLC1 0.53 9.58 0.35 2.12e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs7523273 0.606 rs2761430 chr1:207912408 G/A cg22525895 chr1:207977042 MIR29B2 0.48 12.21 0.43 5.66e-31 Schizophrenia; BRCA cis rs11585357 0.895 rs112208664 chr1:17632010 G/A cg19159961 chr1:17633534 PADI4 0.58 9.68 0.36 8.83e-21 Hair shape; BRCA cis rs7264396 0.790 rs6058288 chr20:34228680 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.71 15.34 0.52 1.87e-45 Total cholesterol levels; BRCA cis rs826838 1.000 rs1963562 chr12:38662896 C/T cg26384229 chr12:38710491 ALG10B 0.85 22.95 0.67 1.8e-85 Heart rate; BRCA cis rs4908768 0.501 rs7527389 chr1:8556545 A/G cg20416874 chr1:8611966 RERE -0.29 -8.29 -0.31 6.52e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2070488 0.965 rs7642472 chr3:38525567 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.07 0.62 7.44e-70 Electrocardiographic conduction measures; BRCA trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg23533926 chr12:111358616 MYL2 -0.41 -8.68 -0.32 3.39e-17 Extrinsic epigenetic age acceleration; BRCA cis rs11098499 0.954 rs28572238 chr4:120316686 T/G cg09307838 chr4:120376055 NA 0.75 16.63 0.55 7.36e-52 Corneal astigmatism; BRCA trans rs9325144 0.647 rs12227834 chr12:38849246 G/C cg23762105 chr12:34175262 ALG10 0.37 8.55 0.32 9.33e-17 Morning vs. evening chronotype; BRCA cis rs7095944 0.613 rs11245366 chr10:126482849 C/T cg08799069 chr10:126477246 METTL10 -0.39 -9.29 -0.34 2.46e-19 Asthma; BRCA cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.74 0.36 5.32e-21 Bipolar disorder; BRCA cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg01939980 chr4:1354348 KIAA1530 0.36 10.26 0.38 5.74e-23 Longevity; BRCA cis rs3741151 0.773 rs73542976 chr11:73127471 A/G cg17517138 chr11:73019481 ARHGEF17 0.88 12.73 0.45 3.1e-33 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs514406 0.505 rs440871 chr1:53173052 C/T cg16325326 chr1:53192061 ZYG11B 0.86 25.13 0.7 2.04e-97 Monocyte count; BRCA cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg06618935 chr21:46677482 NA -0.36 -7.93 -0.3 9.76e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3806843 0.966 rs10053945 chr5:140160127 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.53 -0.35 3.1e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs701145 0.938 rs2971446 chr3:154073445 G/C cg17054900 chr3:154042577 DHX36 0.66 11.59 0.42 2.54e-28 Coronary artery disease; BRCA cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs752010 0.644 rs6700390 chr1:42112554 A/G cg06885757 chr1:42089581 HIVEP3 0.27 9.39 0.35 1.01e-19 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.49 -0.47 1.09e-36 Extrinsic epigenetic age acceleration; BRCA cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.29 -0.31 6.57e-16 Bipolar disorder; BRCA cis rs7646881 0.812 rs79303235 chr3:158444793 C/T cg19483011 chr3:158453295 NA -0.47 -8.18 -0.31 1.5e-15 Tetralogy of Fallot; BRCA cis rs7737355 1.000 rs12521320 chr5:130755920 A/G cg06307176 chr5:131281290 NA -0.5 -9.74 -0.36 5.22e-21 Life satisfaction; BRCA cis rs61931739 0.534 rs11053072 chr12:34202399 A/C cg06521331 chr12:34319734 NA -0.65 -11.93 -0.43 9.53e-30 Morning vs. evening chronotype; BRCA cis rs2486288 0.656 rs7166580 chr15:45571209 C/G cg15395560 chr15:45543142 SLC28A2 0.29 7.85 0.3 1.74e-14 Glomerular filtration rate; BRCA cis rs6430585 0.583 rs59213715 chr2:136646582 A/C cg07169764 chr2:136633963 MCM6 1.22 24.82 0.7 9.71e-96 Corneal structure; BRCA trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.86 0.42 1.81e-29 Corneal astigmatism; BRCA cis rs10463316 0.817 rs10040628 chr5:150821027 T/G cg03212797 chr5:150827313 SLC36A1 -0.44 -8.66 -0.32 3.76e-17 Metabolite levels (Pyroglutamine); BRCA cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg24562669 chr7:97807699 LMTK2 0.46 12.22 0.44 5e-31 Prostate cancer (SNP x SNP interaction); BRCA trans rs2018683 0.624 rs2286220 chr7:28998699 G/C cg19402173 chr7:128379420 CALU -0.48 -11.73 -0.42 6.82e-29 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs953387 1.000 rs2056297 chr2:136899116 G/T cg05194412 chr2:137003533 NA -0.37 -8.62 -0.32 5.45e-17 Arthritis (juvenile idiopathic); BRCA cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.67 0.32 3.53e-17 Coronary artery disease; BRCA cis rs9811920 0.715 rs6810262 chr3:99906342 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 8.94 0.33 4.13e-18 Axial length; BRCA cis rs8005677 1.000 rs7155857 chr14:23400059 C/A cg01529538 chr14:23388837 RBM23 0.41 11.12 0.4 2.25e-26 Cognitive ability (multi-trait analysis); BRCA cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs11758351 0.588 rs2050948 chr6:26234952 A/G cg01420254 chr6:26195488 NA 0.55 8.56 0.32 8.23e-17 Gout;Renal underexcretion gout; BRCA cis rs6543140 0.855 rs4851591 chr2:103077423 T/C cg04239558 chr2:103089729 SLC9A4 0.34 9.6 0.36 1.72e-20 Blood protein levels; BRCA cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg08917208 chr2:24149416 ATAD2B 0.9 12.93 0.46 3.8e-34 Lymphocyte counts; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg27588902 chr6:42928151 GNMT -0.31 -10.15 -0.37 1.49e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg18230493 chr5:56204884 C5orf35 0.53 10.82 0.39 3.71e-25 Type 2 diabetes; BRCA cis rs35146811 0.695 rs1727132 chr7:99812297 T/C cg13334819 chr7:99746414 C7orf59 0.34 8.05 0.3 4.16e-15 Coronary artery disease; BRCA cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7178424 0.875 rs2414753 chr15:62200974 T/C cg00456672 chr15:62358751 C2CD4A -0.42 -9.34 -0.35 1.5700000000000001e-19 Height; BRCA cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs11779988 0.545 rs397096 chr8:17798848 C/G cg01800426 chr8:17659068 MTUS1 0.43 8.99 0.33 2.84e-18 Breast cancer; BRCA cis rs7520050 0.807 rs72688483 chr1:46149209 A/G cg24296786 chr1:45957014 TESK2 -0.47 -10.87 -0.39 2.32e-25 Red blood cell count;Reticulocyte count; BRCA cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg24549020 chr5:56110836 MAP3K1 -0.63 -12.48 -0.44 3.86e-32 Initial pursuit acceleration; BRCA cis rs72781680 0.756 rs2551337 chr2:24006886 C/T cg08917208 chr2:24149416 ATAD2B 0.6 9.72 0.36 6.17e-21 Lymphocyte counts; BRCA cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.534 rs11053000 chr12:34079022 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.77 0.36 4.33e-21 Morning vs. evening chronotype; BRCA cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.56 0.59 7.95e-62 Cognitive function; BRCA cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08109568 chr15:31115862 NA -0.45 -10.55 -0.39 4.37e-24 Huntington's disease progression; BRCA cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.6 0.5 6.87e-42 Personality dimensions; BRCA cis rs7264396 0.836 rs2010565 chr20:34182517 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -11.84 -0.42 2.21e-29 Total cholesterol levels; BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.68 0.59 1.76e-62 Alzheimer's disease; BRCA cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg23711669 chr6:146136114 FBXO30 0.74 15.75 0.53 1.89e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs9815354 1.000 rs56207540 chr3:41976627 G/C cg03022575 chr3:42003672 ULK4 0.7 9.67 0.36 9.51e-21 Pulse pressure;Diastolic blood pressure; BRCA trans rs2204008 0.665 rs11179830 chr12:38220966 T/C cg06521331 chr12:34319734 NA -0.53 -10.02 -0.37 4.82e-22 Bladder cancer; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg12419862 chr22:24373484 LOC391322 -0.92 -24.24 -0.69 1.53e-92 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs34779708 0.897 rs7900480 chr10:35338699 A/G cg03585969 chr10:35415529 CREM -0.42 -8.53 -0.32 1.05e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg23033748 chr14:75592666 NEK9 -0.34 -7.98 -0.3 6.71e-15 Height; BRCA cis rs9837602 0.938 rs10511177 chr3:99724873 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -10.56 -0.39 4.01e-24 Breast cancer; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg26608667 chr7:1196370 ZFAND2A 0.4 9.03 0.34 1.93e-18 Longevity;Endometriosis; BRCA trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg06636001 chr8:8085503 FLJ10661 0.54 10.92 0.4 1.37e-25 Retinal vascular caliber; BRCA cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.61 0.36 1.65e-20 Menopause (age at onset); BRCA cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.78 0.55 1.19e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs910316 0.967 rs4899549 chr14:75647494 G/A cg08847533 chr14:75593920 NEK9 -0.83 -20.34 -0.63 2.66e-71 Height; BRCA cis rs34779708 0.733 rs16935948 chr10:35549748 C/G cg03585969 chr10:35415529 CREM 0.41 8.41 0.32 2.77e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2832077 0.943 rs2832094 chr21:30165910 G/A cg24692254 chr21:30365293 RNF160 -0.46 -8.19 -0.31 1.45e-15 Cognitive test performance; BRCA cis rs10464366 0.957 rs2392618 chr7:39108392 G/A cg18850127 chr7:39170497 POU6F2 0.39 8.24 0.31 1.01e-15 IgG glycosylation; BRCA trans rs11088226 0.645 rs2409457 chr21:33929895 T/C cg09050820 chr6:167586206 TCP10L2 0.76 13.66 0.48 1.9e-37 Gastritis; BRCA trans rs17685 0.672 rs6465011 chr7:75811297 T/C cg19862616 chr7:65841803 NCRNA00174 0.79 24.71 0.7 3.87e-95 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg16812893 chr21:31813075 KRTAP15-1 0.4 9.67 0.36 9.39e-21 HDL cholesterol; BRCA trans rs225245 0.817 rs1634684 chr17:33941051 A/G cg19694781 chr19:47549865 TMEM160 -0.32 -7.85 -0.3 1.78e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs12541635 0.934 rs10955407 chr8:107020648 G/A cg10147462 chr8:107024639 NA 0.35 9.82 0.36 2.76e-21 Age of smoking initiation; BRCA cis rs12618769 0.597 rs4851136 chr2:99060873 A/T cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14240646 chr10:27532245 ACBD5 -0.62 -9.58 -0.35 2.13e-20 Breast cancer; BRCA cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg16414030 chr3:133502952 NA -0.47 -11.19 -0.4 1.11e-26 Iron status biomarkers; BRCA cis rs798766 1.000 rs798766 chr4:1734239 C/T cg10756475 chr4:1757242 NA -0.37 -8.6 -0.32 5.99e-17 Bladder cancer;Urinary bladder cancer; BRCA cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg16262614 chr3:133464971 TF 0.24 7.91 0.3 1.12e-14 Iron status biomarkers (transferrin levels); BRCA trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.63 0.55 7.3e-52 Morning vs. evening chronotype; BRCA cis rs67981189 0.634 rs221898 chr14:71605516 A/G cg15816911 chr14:71606274 NA 0.4 8.89 0.33 6.42e-18 Schizophrenia; BRCA cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.42 0.38 1.42e-23 Motion sickness; BRCA cis rs4722585 0.533 rs2237335 chr7:26200213 A/G cg07876897 chr7:26191696 NFE2L3 0.41 8.77 0.33 1.67e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.72 9.81 0.36 3.06e-21 Initial pursuit acceleration; BRCA cis rs4478858 0.647 rs12752761 chr1:31710888 T/C cg00250761 chr1:31883323 NA -0.32 -8.21 -0.31 1.19e-15 Alcohol dependence; BRCA cis rs1878931 0.582 rs9635562 chr16:3416689 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.49 8.68 0.32 3.34e-17 Body mass index (adult); BRCA cis rs6429082 0.715 rs2131923 chr1:235580821 A/G cg26050004 chr1:235667680 B3GALNT2 -0.55 -13.78 -0.48 4.97e-38 Adiposity; BRCA cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg13736514 chr6:26305472 NA 0.36 11.97 0.43 6.35e-30 Educational attainment; BRCA cis rs3768617 0.510 rs10911254 chr1:183088627 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA trans rs208520 0.802 rs851600 chr6:66893754 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -17.6 -0.57 7.86e-57 Exhaled nitric oxide output; BRCA cis rs611744 0.647 rs13280487 chr8:109270263 G/C cg21045802 chr8:109455806 TTC35 0.34 7.82 0.3 2.18e-14 Dupuytren's disease; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg16431978 chr21:31797932 KRTAP13-3 0.37 9.37 0.35 1.27e-19 HDL cholesterol; BRCA cis rs10181042 0.535 rs2441465 chr2:61311187 C/T cg15711740 chr2:61764176 XPO1 -0.38 -9.54 -0.35 2.85e-20 Crohn's disease; BRCA cis rs35110281 0.600 rs914198 chr21:45117456 A/C cg21573476 chr21:45109991 RRP1B -0.39 -10.23 -0.38 7.64e-23 Mean corpuscular volume; BRCA cis rs6901250 0.851 rs9374624 chr6:117145837 A/C cg12892004 chr6:117198278 RFX6 0.47 10.97 0.4 9.06e-26 C-reactive protein levels; BRCA cis rs4594175 0.926 rs60234748 chr14:51630102 T/C cg23942311 chr14:51606299 NA 0.33 8.27 0.31 7.87e-16 Cancer; BRCA cis rs1577917 0.958 rs12198971 chr6:86525445 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs561341 1.000 rs498391 chr17:30328704 G/A cg00745463 chr17:30367425 LRRC37B -0.53 -8.81 -0.33 1.17e-17 Hip circumference adjusted for BMI; BRCA cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg02951883 chr7:2050386 MAD1L1 -0.53 -11.54 -0.42 4.17e-28 Bipolar disorder and schizophrenia; BRCA cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg02734326 chr4:10020555 SLC2A9 0.4 8.72 0.33 2.46e-17 Bone mineral density; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg23358479 chr7:1110784 C7orf50 -0.47 -7.9 -0.3 1.26e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg16506815 chr2:162101123 NA -0.45 -8.69 -0.32 3.15e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); BRCA cis rs11229555 0.609 rs34133416 chr11:58184720 T/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs2262909 0.962 rs73019842 chr19:22249909 T/G cg17074339 chr11:11642133 GALNTL4 0.42 8.14 0.31 2.13e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs739401 0.611 rs401707 chr11:3050965 T/C cg25174290 chr11:3078921 CARS 0.44 13.75 0.48 6.97e-38 Longevity; BRCA cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg20203395 chr5:56204925 C5orf35 0.63 12.4 0.44 8.78e-32 Initial pursuit acceleration; BRCA cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 9.72 0.36 6.5e-21 Personality dimensions; BRCA cis rs332507 0.830 rs2242425 chr3:124398644 A/G cg05980111 chr3:124395277 KALRN 0.37 8.41 0.32 2.73e-16 Plateletcrit; BRCA cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7092929 0.831 rs667943 chr10:3575417 C/T cg14308648 chr10:3568949 NA 0.45 8.02 0.3 4.92e-15 Coronary artery calcification; BRCA cis rs1865760 1.000 rs9348698 chr6:25929689 T/A cg17691542 chr6:26056736 HIST1H1C 0.52 10.47 0.38 8.91e-24 Height; BRCA cis rs12464559 0.522 rs12472627 chr2:152633114 C/T cg01189475 chr2:152685088 ARL5A 0.56 8.32 0.31 5.3e-16 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg17971929 chr21:40555470 PSMG1 0.75 16.28 0.54 4.32e-50 Cognitive function; BRCA cis rs921968 0.528 rs13022583 chr2:219589175 T/C cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.94e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg02527881 chr3:46936655 PTH1R -0.36 -8.37 -0.31 3.76e-16 Birth weight; BRCA cis rs2336384 1.000 rs6672267 chr1:12054911 A/G cg13216073 chr1:12042593 MFN2 0.46 9.92 0.37 1.18e-21 Platelet count; BRCA cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs9309711 0.961 rs35067331 chr2:3474085 C/T cg10845886 chr2:3471009 TTC15 -0.8 -16.67 -0.55 4.62e-52 Neurofibrillary tangles; BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.05 -0.34 1.66e-18 Total body bone mineral density; BRCA cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.29 -0.31 6.47e-16 Colorectal cancer; BRCA cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg25237894 chr2:233734115 C2orf82 0.4 11.51 0.41 5.29e-28 Coronary artery disease; BRCA cis rs62244186 0.516 rs11922470 chr3:44777795 C/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.59 13.01 0.46 1.7e-34 Depressive symptoms; BRCA trans rs6981523 0.553 rs11783045 chr8:11056175 A/G cg06636001 chr8:8085503 FLJ10661 -0.41 -8.04 -0.3 4.52e-15 Neuroticism; BRCA cis rs4268898 0.527 rs72789910 chr2:24388609 T/G cg06627628 chr2:24431161 ITSN2 -0.81 -14.39 -0.49 7.5e-41 Asthma; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.57 12.04 0.43 3.08e-30 Lymphocyte counts; BRCA trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg03929089 chr4:120376271 NA -0.44 -8.32 -0.31 5.44e-16 Height; BRCA cis rs17270561 0.609 rs7772382 chr6:25708116 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.74 0.33 2.01e-17 Iron status biomarkers; BRCA cis rs4906332 1.000 rs8012127 chr14:103942762 G/A cg04998671 chr14:104000505 TRMT61A -0.43 -9.5 -0.35 4.27e-20 Coronary artery disease; BRCA trans rs62103177 0.608 rs8088089 chr18:77832154 A/G cg05926928 chr17:57297772 GDPD1 -0.77 -10.88 -0.4 2.12e-25 Opioid sensitivity; BRCA cis rs7590368 0.926 rs12621237 chr2:10957538 T/C cg15705551 chr2:10952987 PDIA6 0.46 8.75 0.33 1.86e-17 Educational attainment (years of education); BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg21724239 chr8:58056113 NA 0.62 9.78 0.36 3.87e-21 Developmental language disorder (linguistic errors); BRCA cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.34 -7.97 -0.3 7.46e-15 Alzheimer's disease (late onset); BRCA cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg03452623 chr4:187889614 NA -0.31 -10.06 -0.37 3.36e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.49 0.32 1.42e-16 Menopause (age at onset); BRCA cis rs36051895 0.623 rs6476955 chr9:5256533 C/G cg02405213 chr9:5042618 JAK2 -0.45 -8.58 -0.32 7.16e-17 Pediatric autoimmune diseases; BRCA cis rs1371614 0.545 rs1057115 chr2:27172069 T/C cg00617064 chr2:27272375 NA 0.31 8.0 0.3 5.86e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg03146154 chr1:46216737 IPP 0.47 10.23 0.38 7.6e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg23033748 chr14:75592666 NEK9 0.35 8.17 0.31 1.72e-15 Height; BRCA cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs3784262 0.669 rs4646597 chr15:58300768 G/A cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.8 -0.36 3.14e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2066819 1.000 rs77768890 chr12:56725121 A/G cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs6840360 0.571 rs62329101 chr4:152512239 G/T cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 6.04e-15 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg08885076 chr2:99613938 TSGA10 -0.57 -12.71 -0.45 3.59e-33 Chronic sinus infection; BRCA cis rs2797160 1.000 rs1418639 chr6:125999940 C/T cg05901451 chr6:126070800 HEY2 -0.39 -9.41 -0.35 9.06e-20 Endometrial cancer; BRCA cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.75 0.57 1.29e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 -0.37 -8.16 -0.31 1.81e-15 Tonsillectomy; BRCA cis rs17376456 0.825 rs13161885 chr5:93071242 A/C cg25358565 chr5:93447407 FAM172A 1.16 17.91 0.58 1.93e-58 Diabetic retinopathy; BRCA cis rs75229567 0.618 rs11177853 chr12:70184924 A/G cg10114359 chr12:70132523 RAB3IP 1.17 13.1 0.46 6.84e-35 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs2991971 1.000 rs2991971 chr1:46012748 C/G cg15605315 chr1:45957053 TESK2 0.46 9.37 0.35 1.19e-19 High light scatter reticulocyte count; BRCA cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs524281 0.861 rs1862005 chr11:65863402 T/C cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4.15e-15 Electroencephalogram traits; BRCA cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg13256891 chr4:100009986 ADH5 0.43 8.86 0.33 7.78e-18 Alcohol dependence; BRCA cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg12011299 chr4:100065546 ADH4 0.42 11.1 0.4 2.67e-26 Alcohol dependence; BRCA trans rs11098499 0.954 rs59866101 chr4:120296591 T/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs6543140 0.601 rs78178597 chr2:103023596 G/T cg04239558 chr2:103089729 SLC9A4 0.32 7.84 0.3 1.95e-14 Blood protein levels; BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg12444411 chr7:2802554 GNA12 0.34 8.64 0.32 4.6e-17 Height; BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.27 -0.31 7.72e-16 Gut microbiome composition (summer); BRCA cis rs6840360 0.593 rs11723227 chr4:152689717 G/A cg22705602 chr4:152727874 NA -0.38 -10.45 -0.38 1.08e-23 Intelligence (multi-trait analysis); BRCA cis rs10883723 0.810 rs2296589 chr10:104248106 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.72 0.62 5.57e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs514406 0.679 rs545719 chr1:53304922 T/C cg08859206 chr1:53392774 SCP2 -0.61 -13.04 -0.46 1.29e-34 Monocyte count; BRCA cis rs10129255 0.556 rs6576224 chr14:107186236 G/A cg07958169 chr14:107095056 NA -0.4 -8.48 -0.32 1.59e-16 Kawasaki disease; BRCA cis rs6977660 0.714 rs10155949 chr7:19834747 T/C cg07541023 chr7:19748670 TWISTNB 0.54 9.25 0.34 3.21e-19 Thyroid stimulating hormone; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg16606324 chr3:10149918 C3orf24 0.56 11.06 0.4 3.88e-26 Alzheimer's disease; BRCA cis rs6433895 1.000 rs7558428 chr2:182018554 C/T cg00481216 chr2:181971175 NA -0.39 -9.12 -0.34 9.27e-19 Lymphocyte counts; BRCA cis rs16854884 0.657 rs6778627 chr3:143720869 G/T cg06585982 chr3:143692056 C3orf58 0.42 8.86 0.33 8.11e-18 Economic and political preferences (feminism/equality); BRCA cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.74 -0.42 5.84e-29 Bipolar disorder; BRCA cis rs2070488 0.965 rs3762791 chr3:38568828 T/C cg24069376 chr3:38537580 EXOG -0.42 -12.09 -0.43 1.88e-30 Electrocardiographic conduction measures; BRCA cis rs798554 0.704 rs798503 chr7:2789704 G/A cg04166393 chr7:2884313 GNA12 0.4 8.39 0.31 3.23e-16 Height; BRCA cis rs5771069 0.933 rs137848 chr22:50440296 A/G cg03721641 chr22:50451245 IL17REL 0.3 8.83 0.33 1.02e-17 Ulcerative colitis; BRCA cis rs6714710 0.603 rs6757357 chr2:98491750 T/C cg26665480 chr2:98280029 ACTR1B 0.58 13.5 0.47 9.75e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg26384229 chr12:38710491 ALG10B 0.85 22.64 0.67 8.85e-84 Heart rate; BRCA cis rs9790314 0.747 rs9848239 chr3:160823488 A/C cg03342759 chr3:160939853 NMD3 -0.54 -10.52 -0.38 5.41e-24 Morning vs. evening chronotype; BRCA cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg26248373 chr2:1572462 NA -0.65 -15.81 -0.53 9.41e-48 IgG glycosylation; BRCA cis rs7677751 0.848 rs4635872 chr4:55099041 C/A cg17187183 chr4:55093834 PDGFRA 0.44 9.07 0.34 1.44e-18 Corneal astigmatism; BRCA cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg22903471 chr2:27725779 GCKR -0.36 -8.83 -0.33 1.04e-17 Total body bone mineral density; BRCA cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.39 0.44 9.53e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg27071517 chr21:31768726 KRTAP13-1 0.29 8.08 0.3 3.2e-15 HDL cholesterol; BRCA cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg00074818 chr8:8560427 CLDN23 0.39 8.61 0.32 5.71e-17 Obesity-related traits; BRCA cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg04455712 chr21:45112962 RRP1B 0.4 10.47 0.38 8.8e-24 Mean corpuscular volume; BRCA cis rs7640424 0.659 rs7639774 chr3:107816216 T/G cg09227934 chr3:107805635 CD47 -0.43 -8.19 -0.31 1.44e-15 Body mass index; BRCA cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg00945666 chr1:160990265 F11R -0.27 -8.0 -0.3 6.03e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.33 0.31 4.76e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg03517284 chr6:25882590 NA -0.44 -10.24 -0.38 6.87e-23 Blood metabolite levels; BRCA cis rs992157 0.835 rs4674282 chr2:219144230 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.43 -0.41 1.14e-27 Colorectal cancer; BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.21 0.34 4.65e-19 Tonsillectomy; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg04944784 chr2:26401820 FAM59B -0.66 -11.17 -0.4 1.41e-26 Gut microbiome composition (summer); BRCA cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg11279151 chr3:101281821 RG9MTD1 -0.34 -7.86 -0.3 1.64e-14 Colorectal cancer; BRCA cis rs3768617 0.510 rs6424889 chr1:183091796 G/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.08e-57 Fuchs's corneal dystrophy; BRCA trans rs35110281 0.693 rs2838345 chr21:45092715 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.46 0.32 1.88e-16 Mean corpuscular volume; BRCA cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg01262667 chr19:19385393 TM6SF2 0.41 10.51 0.38 6.09e-24 Tonsillectomy; BRCA cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg06627628 chr2:24431161 ITSN2 -0.54 -8.81 -0.33 1.15e-17 Lymphocyte counts; BRCA cis rs7927592 0.956 rs12271290 chr11:68326236 A/G cg20283391 chr11:68216788 NA 0.43 8.62 0.32 5.07e-17 Total body bone mineral density; BRCA cis rs13082711 0.911 rs13077400 chr3:27473066 A/G cg02860705 chr3:27208620 NA 0.54 10.59 0.39 2.91e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6763687 0.828 rs2219263 chr3:171786974 A/C cg16233210 chr3:171778391 FNDC3B 0.39 8.64 0.32 4.37e-17 Red cell distribution width; BRCA cis rs7833986 0.501 rs2976044 chr8:56986737 A/G cg26371346 chr8:56986568 SNORD54;RPS20 0.42 8.33 0.31 4.82e-16 Height; BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg04518342 chr5:131593106 PDLIM4 0.36 9.09 0.34 1.25e-18 Breast cancer; BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.46 0.35 5.93e-20 Tonsillectomy; BRCA cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.58 11.63 0.42 1.66e-28 Age-related macular degeneration (geographic atrophy); BRCA cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg21926612 chr6:163149169 PACRG;PARK2 1.04 16.01 0.54 9.44e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs68170813 0.559 rs2023892 chr7:106847686 C/T cg02696742 chr7:106810147 HBP1 0.48 8.2 0.31 1.36e-15 Coronary artery disease; BRCA cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg13073564 chr4:8508604 NA -0.38 -10.36 -0.38 2.43e-23 Response to antineoplastic agents; BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.55 11.32 0.41 3.22e-27 Multiple sclerosis; BRCA cis rs17270561 0.609 rs1937132 chr6:25757017 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.8e-17 Iron status biomarkers; BRCA cis rs460214 0.528 rs6517474 chr21:40023133 G/A cg21578987 chr21:40029669 ERG 0.35 8.27 0.31 7.79e-16 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.77e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.851 rs6089827 chr20:61668845 C/T cg08564027 chr20:61660810 NA 0.85 22.71 0.67 3.5e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs4588572 0.644 rs7714871 chr5:77754268 G/T cg11547950 chr5:77652471 NA -0.45 -8.55 -0.32 9.09e-17 Triglycerides; BRCA cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg06108461 chr20:60628389 TAF4 -0.98 -22.1 -0.66 8.19e-81 Body mass index; BRCA cis rs2797160 1.000 rs1777225 chr6:126018270 T/C cg05901451 chr6:126070800 HEY2 0.4 9.62 0.36 1.48e-20 Endometrial cancer; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg21782813 chr7:2030301 MAD1L1 0.41 10.83 0.39 3.14e-25 Bipolar disorder and schizophrenia; BRCA cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -8.7 -0.33 2.91e-17 Response to bleomycin (chromatid breaks); BRCA cis rs2732480 0.577 rs2634678 chr12:48735538 C/G cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 5.97e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg01884057 chr2:25150051 NA 0.34 8.49 0.32 1.4e-16 Body mass index; BRCA cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.5 -9.88 -0.36 1.6e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg06970220 chr1:156163860 SLC25A44 0.39 9.45 0.35 6.4e-20 Testicular germ cell tumor; BRCA cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg18357526 chr6:26021779 HIST1H4A 0.5 9.13 0.34 8.8e-19 Intelligence (multi-trait analysis); BRCA trans rs11039798 0.512 rs11040205 chr11:49007360 G/C cg15704280 chr7:45808275 SEPT13 0.62 10.23 0.38 7.37e-23 Axial length; BRCA cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg05283184 chr6:79620031 NA -0.43 -10.93 -0.4 1.28e-25 Intelligence (multi-trait analysis); BRCA cis rs10992471 0.603 rs10761155 chr9:95153729 C/G cg14631576 chr9:95140430 CENPP -0.39 -9.48 -0.35 5.08e-20 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs13136331 0.532 rs2615477 chr4:88579803 T/C cg22416721 chr4:88570574 DMP1 -0.6 -14.52 -0.5 1.71e-41 Sitting height ratio; BRCA cis rs11690935 0.959 rs6724337 chr2:172735329 C/T cg13550731 chr2:172543902 DYNC1I2 -0.9 -29.48 -0.76 2.81e-121 Schizophrenia; BRCA cis rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05901451 chr6:126070800 HEY2 0.4 9.73 0.36 6.12e-21 Endometrial cancer; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg16145915 chr7:1198662 ZFAND2A -0.7 -19.84 -0.62 1.23e-68 Longevity;Endometriosis; BRCA cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.74 -0.42 5.64e-29 Bipolar disorder; BRCA cis rs295140 0.507 rs13019821 chr2:201106815 C/G cg23649088 chr2:200775458 C2orf69 -0.39 -8.11 -0.31 2.53e-15 QT interval; BRCA cis rs6963495 0.538 rs55967123 chr7:105163678 C/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7520050 0.807 rs28844317 chr1:46209207 T/C cg24296786 chr1:45957014 TESK2 -0.46 -10.54 -0.38 4.68e-24 Red blood cell count;Reticulocyte count; BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs250677 0.687 rs250673 chr5:148445798 C/T cg23229984 chr5:148520753 ABLIM3 0.36 8.74 0.33 2.06e-17 Breast cancer; BRCA trans rs3857536 0.740 rs7769722 chr6:66891363 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs11190604 1.000 rs12354411 chr10:102294537 G/A cg07080220 chr10:102295463 HIF1AN 0.63 14.98 0.51 1.08e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1874326 0.524 rs6968570 chr7:138110039 T/G cg18008034 chr7:138118925 NA -0.44 -9.2 -0.34 5.03e-19 Quantitative traits; BRCA cis rs6435161 0.959 rs72926961 chr2:203489948 G/A cg18429434 chr2:203499731 FAM117B -0.43 -8.28 -0.31 7.37e-16 Total cholesterol levels; BRCA cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg01262667 chr19:19385393 TM6SF2 0.43 11.19 0.4 1.14e-26 Tonsillectomy; BRCA cis rs832540 0.669 rs832539 chr5:56199386 A/C cg24531977 chr5:56204891 C5orf35 -0.63 -13.94 -0.48 8.86e-39 Coronary artery disease; BRCA cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs9399135 0.967 rs1023179 chr6:135343829 T/A cg24558204 chr6:135376177 HBS1L 0.44 12.2 0.43 6.19e-31 Red blood cell count; BRCA cis rs7246657 0.524 rs28542490 chr19:37456584 C/A cg18154014 chr19:37997991 ZNF793 0.52 8.94 0.33 4.31e-18 Coronary artery calcification; BRCA cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.26 0.31 8.22e-16 Aortic root size; BRCA cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs16958440 0.867 rs79285649 chr18:44699019 A/T cg17192377 chr18:44677553 HDHD2 0.99 13.47 0.47 1.43e-36 Sitting height ratio; BRCA cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -8.98 -0.33 2.97e-18 Developmental language disorder (linguistic errors); BRCA cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg24397884 chr7:158709396 WDR60 0.7 15.37 0.52 1.31e-45 Height; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg23708337 chr7:1209742 NA 0.47 7.84 0.3 1.92e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7474896 0.537 rs2749588 chr10:38269457 C/G cg25427524 chr10:38739819 LOC399744 -0.52 -9.65 -0.36 1.12e-20 Obesity (extreme); BRCA cis rs7072216 0.763 rs6584202 chr10:100170383 G/A cg26618903 chr10:100175079 PYROXD2 -0.33 -9.53 -0.35 3.34e-20 Metabolite levels; BRCA cis rs10760123 1 rs10760123 chr9:123650534 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.66 0.32 3.82e-17 Allergic disease (asthma, hay fever or eczema); BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg25036284 chr2:26402008 FAM59B -0.7 -11.49 -0.41 6.85e-28 Gut microbiome composition (summer); BRCA cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.32 0.41 3.23e-27 Monocyte percentage of white cells; BRCA cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg08000102 chr2:233561755 GIGYF2 -0.61 -13.43 -0.47 2.03e-36 Coronary artery disease; BRCA cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.66 17.0 0.56 9.23e-54 Age-related macular degeneration (geographic atrophy); BRCA cis rs9287719 0.967 rs6712304 chr2:10754375 A/C cg02196655 chr2:10830764 NOL10 -0.3 -7.88 -0.3 1.39e-14 Prostate cancer; BRCA cis rs2016266 0.855 rs6580941 chr12:53662199 T/C cg26875137 chr12:53738046 NA 0.39 9.41 0.35 8.82e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg18357645 chr12:58087776 OS9 -0.33 -8.0 -0.3 5.66e-15 Multiple sclerosis; BRCA cis rs939658 0.805 rs8036435 chr15:79420031 T/C cg17916960 chr15:79447300 NA -0.46 -11.49 -0.41 6.72e-28 Refractive error; BRCA cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg00277334 chr10:82204260 NA -0.85 -24.9 -0.7 3.41e-96 Post bronchodilator FEV1; BRCA cis rs7131987 0.903 rs10843371 chr12:29414232 G/A cg09582351 chr12:29534625 ERGIC2 -0.47 -11.56 -0.42 3.34e-28 QT interval; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg04013093 chr6:42928303 GNMT -0.29 -8.93 -0.33 4.64e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.61 12.69 0.45 4.45e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg18230493 chr5:56204884 C5orf35 -0.72 -14.07 -0.49 2.32e-39 Initial pursuit acceleration; BRCA cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg16743903 chr16:89593216 SPG7 0.31 7.81 0.3 2.41e-14 Multiple myeloma (IgH translocation); BRCA cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg03161606 chr19:29218774 NA 0.46 8.11 0.31 2.56e-15 Methadone dose in opioid dependence; BRCA cis rs7917772 0.636 rs4919676 chr10:104524352 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.58 -0.39 3.11e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs2204008 0.685 rs4556621 chr12:38187236 C/A cg06521331 chr12:34319734 NA -0.54 -9.65 -0.36 1.13e-20 Bladder cancer; BRCA cis rs1829883 0.775 rs7717158 chr5:98843529 C/T cg08333243 chr5:99726346 NA -0.36 -8.1 -0.3 2.9e-15 Hemostatic factors and hematological phenotypes; BRCA trans rs35491132 1 rs35491132 chr6:27527227 GT/G cg06606381 chr12:133084897 FBRSL1 -0.84 -8.66 -0.32 3.7e-17 Urinary tract infection frequency; BRCA cis rs9790314 0.967 rs9821201 chr3:160996155 G/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.13 -0.49 1.19e-39 Morning vs. evening chronotype; BRCA cis rs2013441 1.000 rs11654025 chr17:20198160 A/T cg13482628 chr17:19912719 NA -0.37 -8.15 -0.31 1.9e-15 Obesity-related traits; BRCA cis rs10504073 0.584 rs55838473 chr8:49948281 C/A cg00325661 chr8:49890786 NA 0.49 14.23 0.49 4.24e-40 Blood metabolite ratios; BRCA trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -9.21 -0.34 4.72e-19 Morning vs. evening chronotype; BRCA cis rs6430585 0.527 rs7592050 chr2:136459227 C/T cg07169764 chr2:136633963 MCM6 -1.02 -19.72 -0.62 5.72e-68 Corneal structure; BRCA cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg08917208 chr2:24149416 ATAD2B 1.04 14.17 0.49 8.05e-40 Lymphocyte counts; BRCA cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg10057126 chr4:77819792 ANKRD56 0.51 11.01 0.4 6.04e-26 Emphysema distribution in smoking; BRCA cis rs2882667 0.858 rs11956159 chr5:138408568 T/C cg04439458 chr5:138467593 SIL1 -0.43 -10.83 -0.39 3.31e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4862307 0.836 rs6829678 chr4:185001631 C/T cg06737308 chr4:185021514 ENPP6 -0.37 -8.23 -0.31 1.05e-15 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg18132916 chr6:79620363 NA -0.44 -9.89 -0.36 1.47e-21 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg24562669 chr7:97807699 LMTK2 0.44 11.84 0.42 2.12e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg01475377 chr6:109611718 NA -0.6 -16.46 -0.55 5.32e-51 Reticulocyte fraction of red cells; BRCA cis rs2404602 0.735 rs12906143 chr15:76709523 T/A cg23625390 chr15:77176239 SCAPER -0.52 -12.24 -0.44 4.28e-31 Blood metabolite levels; BRCA cis rs1577917 1.000 rs12209127 chr6:86724427 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -12.94 -0.46 3.67e-34 Response to antipsychotic treatment; BRCA cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.663 rs10513559 chr3:160667465 G/A cg03342759 chr3:160939853 NMD3 0.46 8.72 0.33 2.47e-17 Morning vs. evening chronotype; BRCA cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.19e-23 Motion sickness; BRCA cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.78 0.36 3.77e-21 Bipolar disorder; BRCA cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg06970220 chr1:156163860 SLC25A44 0.39 9.47 0.35 5.38e-20 Testicular germ cell tumor; BRCA cis rs858239 0.601 rs73272053 chr7:23155525 A/G cg23682824 chr7:23144976 KLHL7 0.4 10.26 0.38 5.65e-23 Cerebrospinal fluid biomarker levels; BRCA trans rs8073060 0.504 rs225271 chr17:33969836 C/T cg19694781 chr19:47549865 TMEM160 -1.05 -21.83 -0.65 2.3e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1577917 1.000 rs13199006 chr6:86608708 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -11.28 -0.41 5.11e-27 Response to antipsychotic treatment; BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.61 0.61 2.24e-67 Platelet count; BRCA cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg06064525 chr11:970664 AP2A2 -0.49 -16.41 -0.54 9.05e-51 Alzheimer's disease (late onset); BRCA cis rs2180341 0.782 rs6912552 chr6:127722946 C/G cg27446573 chr6:127587934 RNF146 -0.69 -15.6 -0.53 1.01e-46 Breast cancer; BRCA cis rs701145 0.640 rs896016 chr3:153929902 C/T cg17054900 chr3:154042577 DHX36 0.43 8.18 0.31 1.59e-15 Coronary artery disease; BRCA cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg21427119 chr20:30132790 HM13 -0.43 -8.99 -0.33 2.86e-18 Mean corpuscular hemoglobin; BRCA cis rs7903847 0.642 rs10786339 chr10:99153076 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.78 -0.33 1.53e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs72792276 1.000 rs17839658 chr5:127423013 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 10.32 0.38 3.32e-23 Red cell distribution width; BRCA cis rs1678542 0.679 rs10783834 chr12:57975953 G/C cg00677455 chr12:58241039 CTDSP2 0.38 7.81 0.3 2.34e-14 Rheumatoid arthritis; BRCA cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6738485 0.589 rs13021716 chr2:106837931 A/C cg16099169 chr2:106886729 NA -0.37 -7.93 -0.3 9.83e-15 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA trans rs35110281 0.720 rs162375 chr21:44927015 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -10.17 -0.37 1.32e-22 Mean corpuscular volume; BRCA cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg26116260 chr4:7069785 GRPEL1 0.88 22.52 0.67 3.79e-83 Monocyte percentage of white cells; BRCA cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg03517284 chr6:25882590 NA -0.51 -11.52 -0.41 5.1e-28 Blood metabolite levels; BRCA cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg24642439 chr20:33292090 TP53INP2 0.43 8.6 0.32 6.27e-17 Height; BRCA cis rs7607369 0.536 rs12694443 chr2:219664977 G/T cg02176678 chr2:219576539 TTLL4 -0.38 -10.1 -0.37 2.3e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs11249608 0.548 rs35568336 chr5:178451854 A/G cg21905437 chr5:178450457 ZNF879 0.55 11.3 0.41 3.89e-27 Pubertal anthropometrics; BRCA cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -11.74 -0.42 6.17e-29 Chronic sinus infection; BRCA cis rs7903847 0.642 rs11189204 chr10:99164394 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.75 -0.33 1.95e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2832191 0.597 rs8127842 chr21:30516461 G/A cg08807101 chr21:30365312 RNF160 -0.44 -9.44 -0.35 7.1e-20 Dental caries; BRCA cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg05340658 chr4:99064831 C4orf37 0.65 15.98 0.53 1.35e-48 Colonoscopy-negative controls vs population controls; BRCA cis rs9287719 0.967 rs4669599 chr2:10758029 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.99 -0.3 6.39e-15 Prostate cancer; BRCA cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg11663144 chr21:46675770 NA -0.6 -13.88 -0.48 1.88e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1003719 0.751 rs55740803 chr21:38542761 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.23 -0.49 4.16e-40 Eye color traits; BRCA cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg11584989 chr19:19387371 SF4 0.64 13.49 0.47 1.14e-36 Bipolar disorder; BRCA cis rs9462027 0.628 rs7769961 chr6:34760162 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA trans rs4689592 0.503 rs66885632 chr4:7053738 T/C cg07817883 chr1:32538562 TMEM39B 0.53 8.58 0.32 7.44e-17 Monocyte percentage of white cells; BRCA cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg06550200 chr5:1325588 CLPTM1L -0.65 -14.26 -0.49 2.85e-40 Lung cancer; BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.65 10.41 0.38 1.57e-23 Renal function-related traits (BUN); BRCA cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg01181863 chr3:195395398 SDHAP2 -0.46 -8.01 -0.3 5.54e-15 Pancreatic cancer; BRCA cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg12935359 chr14:103987150 CKB -0.59 -13.99 -0.48 5.55e-39 Body mass index; BRCA trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg26516362 chr5:178986906 RUFY1 0.44 12.39 0.44 9.58e-32 Lung cancer; BRCA cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg26384229 chr12:38710491 ALG10B 0.84 22.26 0.66 1.06e-81 Heart rate; BRCA cis rs4237845 0.537 rs9645819 chr12:58270063 T/C cg00677455 chr12:58241039 CTDSP2 0.64 15.95 0.53 1.79e-48 Intelligence (multi-trait analysis); BRCA cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg03161606 chr19:29218774 NA 0.46 8.04 0.3 4.23e-15 Methadone dose in opioid dependence; BRCA cis rs6089584 0.527 rs927589 chr20:60606363 A/G cg13770153 chr20:60521292 NA -0.39 -9.17 -0.34 6.67e-19 Body mass index; BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg22920501 chr2:26401640 FAM59B -0.9 -16.0 -0.53 1.07e-48 Gut microbiome composition (summer); BRCA cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg20701182 chr2:24300061 SF3B14 0.66 9.65 0.36 1.17e-20 Lymphocyte counts; BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13126279 chr21:47581558 C21orf56 -0.5 -10.68 -0.39 1.29e-24 Testicular germ cell tumor; BRCA cis rs73086581 1.000 rs56324992 chr20:3978153 C/A cg02187196 chr20:3869020 PANK2 0.43 7.83 0.3 2.07e-14 Response to antidepressants in depression; BRCA cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg16339924 chr4:17578868 LAP3 0.6 14.62 0.5 5.9e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 0.964 rs697969 chr7:65558478 C/A cg11764359 chr7:65958608 NA -0.77 -18.03 -0.58 4.5e-59 Aortic root size; BRCA cis rs11105298 0.891 rs10777185 chr12:89921275 C/T cg00757033 chr12:89920650 WDR51B 0.55 11.24 0.41 7.05e-27 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs55882075 1.000 rs55882075 chr5:179210115 C/G cg14593053 chr5:179126677 CANX 0.41 10.31 0.38 3.6e-23 Monocyte percentage of white cells; BRCA cis rs9467773 0.967 rs7753565 chr6:26560012 A/G cg11502198 chr6:26597334 ABT1 0.48 9.69 0.36 8.28e-21 Intelligence (multi-trait analysis); BRCA cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg06026331 chr20:60912101 LAMA5 0.61 12.03 0.43 3.57e-30 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.82 -0.33 1.07e-17 Alzheimer's disease (late onset); BRCA cis rs3857067 0.836 rs12501138 chr4:95098444 T/A cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.33 -0.35 1.66e-19 QT interval; BRCA cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg18964960 chr10:1102726 WDR37 0.53 9.03 0.34 1.97e-18 Response to angiotensin II receptor blocker therapy; BRCA cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg23583168 chr7:148888333 NA -0.79 -18.98 -0.6 4.88e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2559856 1.000 rs2695284 chr12:102089318 A/G cg12924262 chr12:102091054 CHPT1 -0.38 -8.57 -0.32 7.86e-17 Blood protein levels; BRCA cis rs6088813 0.885 rs224331 chr20:34022387 A/C cg14752227 chr20:34000481 UQCC 0.39 7.85 0.3 1.73e-14 Height; BRCA cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11890956 chr21:40555474 PSMG1 1.05 30.01 0.76 3.89e-124 Cognitive function; BRCA cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg03709012 chr19:19516395 GATAD2A -0.75 -16.72 -0.55 2.46e-52 Tonsillectomy; BRCA cis rs4423214 0.879 rs1792264 chr11:71150247 C/T cg05163923 chr11:71159392 DHCR7 -0.57 -11.65 -0.42 1.42e-28 Vitamin D levels; BRCA cis rs875971 0.862 rs801195 chr7:66026115 A/G cg11764359 chr7:65958608 NA -0.76 -16.79 -0.55 1.17e-52 Aortic root size; BRCA cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg05283184 chr6:79620031 NA -0.41 -10.63 -0.39 2.12e-24 Intelligence (multi-trait analysis); BRCA trans rs1997103 1.000 rs12718956 chr7:55407763 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs250677 0.958 rs36068 chr5:148417512 C/T cg12140854 chr5:148520817 ABLIM3 -0.43 -9.07 -0.34 1.41e-18 Breast cancer; BRCA cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg01579765 chr21:45077557 HSF2BP 0.44 12.27 0.44 3.11e-31 Mean corpuscular volume; BRCA cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg06671706 chr8:8559999 CLDN23 0.44 8.48 0.32 1.59e-16 Obesity-related traits; BRCA trans rs9858542 0.953 rs6779524 chr3:49450449 C/T cg21659725 chr3:3221576 CRBN -0.45 -9.93 -0.37 1.03e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.48 0.5 2.81e-41 Motion sickness; BRCA cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg12386194 chr3:101231763 SENP7 0.46 9.88 0.36 1.64e-21 Colorectal cancer; BRCA cis rs68170813 0.559 rs79705824 chr7:106848325 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.44 -0.32 2.11e-16 Coronary artery disease; BRCA cis rs6496044 0.568 rs11855789 chr15:86066403 G/A cg10818794 chr15:86012489 AKAP13 -0.29 -7.91 -0.3 1.1e-14 Interstitial lung disease; BRCA cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.31 -0.31 5.84e-16 Electroencephalogram traits; BRCA cis rs7903847 0.646 rs10882924 chr10:99159304 T/A cg08345082 chr10:99160200 RRP12 -0.3 -8.86 -0.33 7.98e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs6750047 0.781 rs4670809 chr2:38277364 A/C cg07380506 chr2:38303506 CYP1B1 0.36 8.16 0.31 1.77e-15 Cutaneous malignant melanoma;Melanoma; BRCA cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11890956 chr21:40555474 PSMG1 -0.84 -21.56 -0.65 6.65e-78 Cognitive function; BRCA cis rs2718798 1 rs2718798 chr3:133492088 A/C cg01448562 chr3:133502909 NA -0.38 -8.72 -0.33 2.36e-17 Ankle injury; BRCA cis rs514406 0.893 rs476108 chr1:53317351 C/T cg27535305 chr1:53392650 SCP2 -0.37 -9.32 -0.35 1.85e-19 Monocyte count; BRCA cis rs8062405 1.000 rs55991577 chr16:28843025 C/T cg16576597 chr16:28551801 NUPR1 0.3 8.32 0.31 5.25e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg16482183 chr6:26056742 HIST1H1C -0.57 -10.94 -0.4 1.16e-25 Iron status biomarkers; BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.7 14.15 0.49 1.01e-39 Alzheimer's disease; BRCA cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.17 -0.4 1.42e-26 Extrinsic epigenetic age acceleration; BRCA cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.82 0.45 1.24e-33 Bipolar disorder; BRCA cis rs6543140 0.964 rs6543144 chr2:103092575 A/G cg04239558 chr2:103089729 SLC9A4 0.36 9.9 0.36 1.37e-21 Blood protein levels; BRCA cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg21573476 chr21:45109991 RRP1B 0.31 7.99 0.3 6.39e-15 Mean corpuscular volume; BRCA cis rs2404602 0.503 rs284909 chr15:76736628 C/T cg23625390 chr15:77176239 SCAPER 0.46 11.53 0.42 4.4e-28 Blood metabolite levels; BRCA cis rs2147904 0.934 rs2786487 chr1:42368339 C/G cg16685388 chr1:42384056 HIVEP3 -0.36 -10.17 -0.37 1.33e-22 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg15782153 chr7:917662 C7orf20 0.39 9.42 0.35 8.39e-20 Perceived unattractiveness to mosquitoes; BRCA cis rs832540 0.564 rs33329 chr5:56145068 T/C cg24531977 chr5:56204891 C5orf35 -0.54 -11.41 -0.41 1.4e-27 Coronary artery disease; BRCA cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg17971929 chr21:40555470 PSMG1 0.8 18.71 0.59 1.3e-62 Cognitive function; BRCA cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg05283184 chr6:79620031 NA -0.39 -9.9 -0.36 1.4e-21 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA trans rs1994135 0.617 rs1384590 chr12:33734271 C/T cg26384229 chr12:38710491 ALG10B 0.48 10.3 0.38 4.15e-23 Resting heart rate; BRCA trans rs4650994 0.625 rs6681354 chr1:178526279 A/G cg05059571 chr16:84539110 KIAA1609 -0.42 -9.44 -0.35 7.1e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.02 26.51 0.72 4.86e-105 Cognitive ability; BRCA cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.44 -0.44 5.63e-32 Personality dimensions; BRCA cis rs9814567 1.000 rs9829092 chr3:134229866 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.45 -0.61 1.55e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6456156 0.792 rs2039321 chr6:167516299 C/T cg07741184 chr6:167504864 NA 0.31 8.96 0.33 3.51e-18 Primary biliary cholangitis; BRCA trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.96 -0.37 7.87e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs3925075 0.531 rs4597342 chr16:31343769 T/C cg02846316 chr16:31340340 ITGAM 0.43 8.73 0.33 2.22e-17 IgA nephropathy; BRCA cis rs1209950 1.000 rs1013841 chr21:40173345 A/G cg01359822 chr21:40176597 ETS2 0.34 8.52 0.32 1.17e-16 Non-small cell lung cancer (survival); BRCA cis rs13046373 0.535 rs9977510 chr21:32027920 A/G cg16812893 chr21:31813075 KRTAP15-1 0.37 9.13 0.34 8.8e-19 HDL cholesterol; BRCA cis rs2070488 0.775 rs1073506 chr3:38566235 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.57 -15.0 -0.51 8.3e-44 Electrocardiographic conduction measures; BRCA trans rs11098499 0.618 rs28491261 chr4:120294900 C/A cg25214090 chr10:38739885 LOC399744 0.51 11.58 0.42 2.83e-28 Corneal astigmatism; BRCA cis rs9467773 1.000 rs6910899 chr6:26524339 A/G cg11502198 chr6:26597334 ABT1 0.48 9.59 0.35 2.02e-20 Intelligence (multi-trait analysis); BRCA cis rs7258465 1.000 rs7251653 chr19:18608283 C/T cg01065977 chr19:18549689 ISYNA1 -0.28 -8.21 -0.31 1.18e-15 Breast cancer; BRCA cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.43 8.3 0.31 6.18e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg25358565 chr5:93447407 FAM172A -1.18 -17.53 -0.57 1.81e-56 Diabetic retinopathy; BRCA cis rs332507 0.789 rs11928787 chr3:124408149 C/T cg05980111 chr3:124395277 KALRN 0.38 8.7 0.33 2.89e-17 Plateletcrit; BRCA cis rs36051895 0.664 rs28378223 chr9:5113087 C/G cg02405213 chr9:5042618 JAK2 -0.48 -9.37 -0.35 1.2e-19 Pediatric autoimmune diseases; BRCA cis rs61931739 0.534 rs11053047 chr12:34161084 C/T cg06521331 chr12:34319734 NA -0.63 -11.49 -0.41 6.35e-28 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.45e-84 Chronic sinus infection; BRCA cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.01 15.68 0.53 4.08e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4588572 0.570 rs2115433 chr5:77700363 C/T cg11547950 chr5:77652471 NA -0.44 -8.39 -0.32 3.07e-16 Triglycerides; BRCA cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg22875332 chr1:76189707 ACADM 0.66 15.77 0.53 1.39e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11098499 0.743 rs10003567 chr4:120241674 C/T cg09307838 chr4:120376055 NA 0.64 13.93 0.48 1.02e-38 Corneal astigmatism; BRCA cis rs9462027 0.651 rs9469885 chr6:34758716 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.33e-15 Systemic lupus erythematosus; BRCA cis rs28830936 0.967 rs9672671 chr15:41917075 C/T cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.28 -0.34 2.54e-19 Diastolic blood pressure; BRCA cis rs3740540 0.530 rs10751598 chr10:126290951 A/G cg04949429 chr10:126290192 LHPP -0.42 -12.07 -0.43 2.41e-30 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs4631830 0.896 rs7088225 chr10:51522120 T/C cg20129853 chr10:51489980 NA 0.29 7.93 0.3 9.64e-15 Prostate-specific antigen levels; BRCA cis rs4588572 0.688 rs1594055 chr5:77695088 G/A cg11547950 chr5:77652471 NA -0.43 -8.29 -0.31 6.51e-16 Triglycerides; BRCA trans rs11098499 0.863 rs58452170 chr4:120459674 A/T cg25214090 chr10:38739885 LOC399744 0.56 12.24 0.44 4.11e-31 Corneal astigmatism; BRCA cis rs7647973 0.626 rs4855845 chr3:49687043 T/C cg07636037 chr3:49044803 WDR6 0.51 8.4 0.32 2.94e-16 Menarche (age at onset); BRCA cis rs10089 0.953 rs3805615 chr5:127519049 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.63 14.72 0.5 1.84e-42 Ileal carcinoids; BRCA cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg21770322 chr7:97807741 LMTK2 0.43 11.49 0.41 6.49e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg18305652 chr10:134549665 INPP5A 0.5 11.54 0.42 4.03e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg02297831 chr4:17616191 MED28 0.38 8.88 0.33 6.9e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2777491 0.540 rs7164684 chr15:41705008 G/T cg18705301 chr15:41695430 NDUFAF1 -1.08 -25.41 -0.71 5.37e-99 Ulcerative colitis; BRCA cis rs6430585 0.528 rs79826902 chr2:136670419 G/A cg07169764 chr2:136633963 MCM6 1.22 23.92 0.69 8.51e-91 Corneal structure; BRCA cis rs6088813 1.000 rs6141549 chr20:33974051 T/C cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.1e-17 Height; BRCA cis rs3960554 0.808 rs59882870 chr7:75638421 G/A cg17325771 chr7:75508891 RHBDD2 -0.33 -8.0 -0.3 6.04e-15 Eotaxin levels; BRCA cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg24578937 chr1:2090814 PRKCZ 0.35 10.77 0.39 5.97e-25 Height; BRCA cis rs9359856 0.564 rs17584290 chr6:90467114 T/G cg13799429 chr6:90582589 CASP8AP2 -0.7 -8.55 -0.32 8.85e-17 Bipolar disorder; BRCA cis rs72792276 1.000 rs10519971 chr5:127379216 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.62 -10.71 -0.39 1.03e-24 Red cell distribution width; BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.33 0.38 3.14e-23 Gut microbiome composition (summer); BRCA trans rs877282 0.898 rs71489279 chr10:760510 T/C cg22713356 chr15:30763199 NA 1.29 24.34 0.69 4.4e-93 Uric acid levels; BRCA cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg11062466 chr8:58055876 NA 0.51 8.86 0.33 8.08e-18 Developmental language disorder (linguistic errors); BRCA cis rs10876993 0.890 rs774887 chr12:58034835 A/G cg18357645 chr12:58087776 OS9 0.43 11.75 0.42 5.42e-29 Celiac disease or Rheumatoid arthritis; BRCA cis rs752010 0.714 rs6600384 chr1:42085141 A/G cg06885757 chr1:42089581 HIVEP3 -0.27 -9.64 -0.36 1.32e-20 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs1994135 0.692 rs1816958 chr12:33695066 A/T cg26384229 chr12:38710491 ALG10B 0.39 8.59 0.32 6.67e-17 Resting heart rate; BRCA cis rs870825 0.860 rs72703527 chr4:185605997 C/A cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs67981189 0.896 rs2158997 chr14:71497794 C/G cg15816911 chr14:71606274 NA -0.36 -8.23 -0.31 1.02e-15 Schizophrenia; BRCA cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg04317338 chr11:64019027 PLCB3 0.57 9.68 0.36 9.03e-21 Mean platelet volume; BRCA trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg14343924 chr8:8086146 FLJ10661 0.39 8.27 0.31 7.69e-16 Neuroticism; BRCA trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.63e-30 Corneal astigmatism; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg24101359 chr6:42928495 GNMT 0.61 14.92 0.51 2.02e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6545883 0.929 rs55806663 chr2:61740487 G/T cg15711740 chr2:61764176 XPO1 -0.55 -14.18 -0.49 6.89e-40 Tuberculosis; BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg25036284 chr2:26402008 FAM59B -0.8 -12.42 -0.44 7.32e-32 Gut microbiome composition (summer); BRCA cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.1 0.37 2.28e-22 Bipolar disorder; BRCA cis rs1451375 0.652 rs10249420 chr7:50623451 C/G cg18232548 chr7:50535776 DDC -0.38 -8.19 -0.31 1.38e-15 Malaria; BRCA cis rs713587 0.520 rs530951 chr2:25307005 C/T cg01884057 chr2:25150051 NA -0.32 -8.26 -0.31 8.59e-16 Body mass index in non-asthmatics; BRCA cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg23788917 chr6:8435910 SLC35B3 -0.44 -9.48 -0.35 4.73e-20 Motion sickness; BRCA cis rs10752881 0.602 rs9425569 chr1:182942202 C/T ch.1.3577855R chr1:183094577 LAMC1 0.49 11.09 0.4 3.04e-26 Colorectal cancer; BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg00106254 chr7:1943704 MAD1L1 0.36 10.07 0.37 3.15e-22 Bipolar disorder and schizophrenia; BRCA cis rs2066819 1.000 rs79718165 chr12:56644251 C/T cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs7683537 0.887 rs7678412 chr4:185648611 T/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Systemic lupus erythematosus; BRCA cis rs875971 1.000 rs4717292 chr7:65895598 G/A cg11764359 chr7:65958608 NA 0.79 19.19 0.6 3.68e-65 Aortic root size; BRCA cis rs6543140 0.964 rs918000 chr2:103067862 C/T cg04239558 chr2:103089729 SLC9A4 0.34 9.55 0.35 2.73e-20 Blood protein levels; BRCA cis rs6445967 0.832 rs1055973 chr3:58308960 T/C cg23715586 chr3:58305044 RPP14 0.35 8.73 0.33 2.25e-17 Platelet count; BRCA cis rs1003719 0.667 rs28666643 chr21:38455999 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 11.28 0.41 4.7e-27 Eye color traits; BRCA cis rs11229555 0.609 rs34782543 chr11:58187398 G/A cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.05e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs698833 0.859 rs1067360 chr2:44661817 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 9.43 0.35 7.46e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg04455712 chr21:45112962 RRP1B 0.46 11.72 0.42 6.9e-29 Mean corpuscular volume; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18402987 chr7:1209562 NA 0.61 12.94 0.46 3.62e-34 Longevity;Endometriosis; BRCA cis rs9872999 1 rs9872999 chr3:133457514 C/T cg16262614 chr3:133464971 TF 0.24 7.82 0.3 2.18e-14 Iron status biomarkers; BRCA cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg19784903 chr17:45786737 TBKBP1 -0.46 -11.13 -0.4 1.96e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs9858542 0.953 rs7623659 chr3:49414791 C/T cg21659725 chr3:3221576 CRBN -0.45 -9.86 -0.36 1.94e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs9297145 0.565 rs56132062 chr7:98778198 C/T cg05967295 chr7:98741636 SMURF1 -0.62 -13.76 -0.48 6.7e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.68e-24 Motion sickness; BRCA cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Depression; BRCA trans rs7746199 0.736 rs13192965 chr6:27671825 G/A cg06606381 chr12:133084897 FBRSL1 -0.89 -8.8 -0.33 1.28e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.02 0.3 5.23e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2243480 1.000 rs6970243 chr7:65388490 C/A cg18252515 chr7:66147081 NA -0.84 -12.14 -0.43 1.2e-30 Diabetic kidney disease; BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.84 -0.42 2.16e-29 Gut microbiome composition (summer); BRCA trans rs8002861 0.870 rs4942251 chr13:44440048 G/T cg17145862 chr1:211918768 LPGAT1 0.63 16.12 0.54 2.56e-49 Leprosy; BRCA cis rs17539620 0.624 rs117591255 chr6:154839118 G/A cg20019720 chr6:154832845 CNKSR3 0.52 10.35 0.38 2.56e-23 Lipoprotein (a) levels; BRCA cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg01579765 chr21:45077557 HSF2BP 0.4 10.25 0.38 6.52e-23 Mean corpuscular volume; BRCA trans rs6598955 0.627 rs6684875 chr1:26567044 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.54 0.47 6.44e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18765753 chr7:1198926 ZFAND2A -0.54 -13.87 -0.48 1.9e-38 Longevity;Endometriosis; BRCA cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg26248373 chr2:1572462 NA -0.62 -14.37 -0.49 8.48e-41 IgG glycosylation; BRCA cis rs6430585 0.528 rs12464050 chr2:136663110 G/T cg07169764 chr2:136633963 MCM6 1.23 23.98 0.69 4.14e-91 Corneal structure; BRCA cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg14530993 chr4:882597 GAK 0.56 9.29 0.35 2.32e-19 Intelligence (multi-trait analysis); BRCA cis rs9611519 0.894 rs4821990 chr22:41438710 A/C cg03806693 chr22:41940476 POLR3H -0.56 -9.86 -0.36 1.84e-21 Neuroticism; BRCA cis rs2404602 0.684 rs62026898 chr15:76944371 C/A cg23625390 chr15:77176239 SCAPER -0.54 -13.71 -0.48 1.09e-37 Blood metabolite levels; BRCA cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg01475377 chr6:109611718 NA -0.6 -16.64 -0.55 6.47e-52 Reticulocyte fraction of red cells; BRCA cis rs2346177 0.542 rs6757564 chr2:46702619 G/C cg02822958 chr2:46747628 ATP6V1E2 0.54 11.58 0.42 2.75e-28 HDL cholesterol; BRCA cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg05890377 chr2:74357713 NA 0.51 11.74 0.42 5.98e-29 Gestational age at birth (maternal effect); BRCA cis rs6723226 0.598 rs2710629 chr2:32765844 C/T cg02381751 chr2:32503542 YIPF4 0.47 10.27 0.38 5.14e-23 Intelligence (multi-trait analysis); BRCA cis rs290268 1.000 rs290274 chr9:93546913 C/T cg02608019 chr9:93564028 SYK 0.54 12.02 0.43 3.72e-30 Platelet count; BRCA cis rs586533 0.881 rs5006806 chr11:99506226 C/A cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg00277334 chr10:82204260 NA -0.82 -23.14 -0.68 1.58e-86 Post bronchodilator FEV1; BRCA cis rs965469 0.895 rs6139124 chr20:3398144 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -10.21 -0.37 8.88e-23 IFN-related cytopenia; BRCA cis rs7729447 0.813 rs7715279 chr5:32689875 T/A cg16267343 chr5:32710456 NPR3 0.44 8.94 0.33 4.27e-18 Blood pressure; BRCA cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 10.83 0.39 3.4e-25 Personality dimensions; BRCA cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.57e-22 Bladder cancer; BRCA cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.45e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9469578 1.000 rs16869464 chr6:33715127 A/G cg18708504 chr6:33715942 IP6K3 0.7 10.19 0.37 1.09e-22 Phosphorus levels; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19346786 chr7:2764209 NA -0.34 -10.62 -0.39 2.17e-24 Height; BRCA trans rs61931739 0.534 rs11052957 chr12:33995354 G/A cg26384229 chr12:38710491 ALG10B 0.48 10.61 0.39 2.41e-24 Morning vs. evening chronotype; BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg00106254 chr7:1943704 MAD1L1 -0.35 -8.74 -0.33 2.04e-17 Schizophrenia; BRCA cis rs9341808 0.650 rs6909546 chr6:80869923 C/G cg08355045 chr6:80787529 NA 0.37 9.24 0.34 3.63e-19 Sitting height ratio; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg20007245 chr22:24372913 LOC391322 -0.57 -12.81 -0.45 1.34e-33 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg27446573 chr6:127587934 RNF146 0.68 15.48 0.52 3.72e-46 Breast cancer; BRCA cis rs11676348 0.776 rs11690316 chr2:219017462 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.43 -8.9 -0.33 5.54e-18 Ulcerative colitis; BRCA cis rs1832871 0.711 rs9459826 chr6:158680396 C/G cg07215822 chr6:158701037 NA 0.51 8.31 0.31 5.94e-16 Height; BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg00814883 chr7:100076585 TSC22D4 -0.54 -11.63 -0.42 1.77e-28 Platelet count; BRCA cis rs1267303 0.642 rs6670699 chr1:46997270 C/T cg25110126 chr1:46999211 NA 0.74 13.81 0.48 3.64e-38 Monobrow; BRCA cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg20607798 chr8:58055168 NA 0.54 8.39 0.31 3.17e-16 Developmental language disorder (linguistic errors); BRCA trans rs3960554 0.808 rs868555 chr7:75697418 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 12.55 0.44 1.93e-32 Eotaxin levels; BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg16606324 chr3:10149918 C3orf24 0.57 9.94 0.37 1e-21 Alzheimer's disease; BRCA cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs9815354 0.812 rs73073230 chr3:42008263 G/A cg03022575 chr3:42003672 ULK4 0.74 10.29 0.38 4.49e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs2732480 0.577 rs2732448 chr12:48730600 T/C cg04545296 chr12:48745243 ZNF641 0.25 8.18 0.31 1.52e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs754466 0.651 rs10762767 chr10:79645070 C/A cg17075019 chr10:79541650 NA -0.73 -17.54 -0.57 1.53e-56 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs6598955 0.671 rs11247909 chr1:26640135 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.79 -0.53 1.16e-47 Obesity-related traits; BRCA cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -8.44 -0.32 2.15e-16 Personality dimensions; BRCA cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg01579765 chr21:45077557 HSF2BP -0.42 -11.52 -0.41 4.82e-28 Mean corpuscular volume; BRCA cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg01939980 chr4:1354348 KIAA1530 0.38 9.05 0.34 1.7e-18 Obesity-related traits; BRCA cis rs4074536 0.574 rs10801969 chr1:116287634 A/G cg21648376 chr1:116311395 CASQ2 -0.48 -8.43 -0.32 2.24e-16 QRS duration; BRCA cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -11.28 -0.41 4.93e-27 Schizophrenia; BRCA cis rs13082711 0.595 rs7615321 chr3:27368010 A/G cg02860705 chr3:27208620 NA 0.71 13.12 0.46 5.32e-35 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs10883723 0.810 rs12162 chr10:104240498 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.57 13.32 0.47 6.57e-36 Allergic disease (asthma, hay fever or eczema); BRCA trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.44 0.35 6.58e-20 Intelligence (multi-trait analysis); BRCA cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg18016565 chr1:150552671 MCL1 0.34 7.81 0.3 2.33e-14 Melanoma; BRCA cis rs7582180 0.614 rs1530031 chr2:101009326 T/C cg14675211 chr2:100938903 LONRF2 0.43 9.69 0.36 8.25e-21 Intelligence (multi-trait analysis); BRCA cis rs965469 1.000 rs6051716 chr20:3267736 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -9.49 -0.35 4.55e-20 IFN-related cytopenia; BRCA cis rs4423214 0.559 rs10898203 chr11:71203436 C/T cg05163923 chr11:71159392 DHCR7 -0.51 -8.73 -0.33 2.16e-17 Vitamin D levels; BRCA cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08704250 chr15:31115839 NA -0.48 -12.23 -0.44 4.9e-31 Huntington's disease progression; BRCA trans rs877282 0.520 rs12360072 chr10:813082 C/T cg22713356 chr15:30763199 NA 0.53 9.91 0.36 1.27e-21 Uric acid levels; BRCA cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs6866344 0.697 rs62392831 chr5:178134365 A/G cg03877680 chr5:178157825 ZNF354A 0.79 14.65 0.5 4.19e-42 Neutrophil percentage of white cells; BRCA cis rs6820391 0.816 rs7681869 chr4:54447773 G/A cg04173182 chr4:54446035 LNX1 0.53 11.85 0.42 1.98e-29 Cervical artery dissection; BRCA cis rs9287719 0.967 rs10929688 chr2:10756650 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.1e-15 Prostate cancer; BRCA cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 0.36 9.13 0.34 8.63e-19 Blood protein levels;Circulating chemerin levels; BRCA cis rs9914988 0.943 rs2874253 chr17:27157863 A/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.8 -0.33 1.25e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs6840360 0.571 rs4696271 chr4:152509118 G/A cg22705602 chr4:152727874 NA -0.31 -7.83 -0.3 2.09e-14 Intelligence (multi-trait analysis); BRCA cis rs2120243 1.000 rs9289982 chr3:157144444 G/C cg01018701 chr3:157155998 VEPH1;PTX3 0.4 8.91 0.33 5.35e-18 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs36051895 0.586 rs12342421 chr9:5065750 G/C cg02405213 chr9:5042618 JAK2 -0.53 -9.25 -0.34 3.21e-19 Pediatric autoimmune diseases; BRCA cis rs6964587 0.626 rs6972945 chr7:91549576 C/G cg17063962 chr7:91808500 NA -0.55 -12.68 -0.45 5.13e-33 Breast cancer; BRCA cis rs4728302 0.869 rs10224575 chr7:133590875 G/A cg07491979 chr7:133331646 EXOC4 0.36 7.81 0.3 2.32e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs7903847 0.642 rs10786341 chr10:99158607 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.73 -0.33 2.16e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs8180040 0.739 rs4683320 chr3:47152992 C/T cg16586182 chr3:47516702 SCAP -0.57 -13.11 -0.46 6.28e-35 Colorectal cancer; BRCA cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg13902645 chr11:5959945 NA 0.53 11.08 0.4 3.36e-26 DNA methylation (variation); BRCA trans rs2562456 0.917 rs11085463 chr19:21751302 G/T cg25042112 chr7:64838748 ZNF92 -0.44 -8.61 -0.32 5.47e-17 Pain; BRCA cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg11833968 chr6:79620685 NA -0.43 -9.51 -0.35 3.74e-20 Intelligence (multi-trait analysis); BRCA cis rs12612619 0.732 rs920433 chr2:27212526 A/C cg00617064 chr2:27272375 NA -0.31 -8.16 -0.31 1.72e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs68170813 0.562 rs78181351 chr7:106999301 A/G cg02696742 chr7:106810147 HBP1 -0.55 -8.61 -0.32 5.89e-17 Coronary artery disease; BRCA cis rs6964587 1.000 rs10234434 chr7:91673308 A/T cg01689657 chr7:91764605 CYP51A1 0.22 8.14 0.31 2.13e-15 Breast cancer; BRCA cis rs1267303 0.642 rs116078607 chr1:46999238 G/A cg25110126 chr1:46999211 NA 0.74 13.93 0.48 1.1e-38 Monobrow; BRCA cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg19628046 chr18:33552617 C18orf21 0.54 10.95 0.4 1.12e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg24675658 chr1:53192096 ZYG11B 0.66 14.41 0.5 5.75e-41 Monocyte count; BRCA cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.02 0.62 1.47e-69 Chronic sinus infection; BRCA cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg11890956 chr21:40555474 PSMG1 1.0 26.11 0.72 7.56e-103 Cognitive function; BRCA cis rs3820928 0.904 rs10188570 chr2:227792540 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -8.24 -0.31 9.57e-16 Pulmonary function; BRCA cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg06064525 chr11:970664 AP2A2 -0.49 -16.41 -0.54 9.05e-51 Alzheimer's disease (late onset); BRCA trans rs3857536 0.813 rs6455083 chr6:66935406 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA trans rs7819412 0.595 rs10106914 chr8:10987651 T/G cg06636001 chr8:8085503 FLJ10661 -0.5 -10.4 -0.38 1.59e-23 Triglycerides; BRCA cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.07 -0.34 1.5e-18 Developmental language disorder (linguistic errors); BRCA cis rs11229555 1.000 rs10896795 chr11:58366561 A/G cg15696309 chr11:58395628 NA -0.52 -11.32 -0.41 3.39e-27 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg12373951 chr3:133503437 NA -0.54 -13.11 -0.46 5.94e-35 Iron status biomarkers; BRCA cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg10932868 chr11:921992 NA -0.49 -12.5 -0.44 3.23e-32 Alzheimer's disease (late onset); BRCA cis rs7772486 0.846 rs1331636 chr6:146338826 T/C cg23711669 chr6:146136114 FBXO30 0.72 16.53 0.55 2.2e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg26384229 chr12:38710491 ALG10B -0.58 -13.43 -0.47 2.13e-36 Morning vs. evening chronotype; BRCA cis rs7178424 1.000 rs1436964 chr15:62374487 A/G cg00456672 chr15:62358751 C2CD4A -0.35 -8.3 -0.31 6.42e-16 Height; BRCA cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg27535305 chr1:53392650 SCP2 -0.38 -9.28 -0.34 2.59e-19 Monocyte count; BRCA cis rs9790314 0.846 rs13083229 chr3:161008125 G/A cg03342759 chr3:160939853 NMD3 -0.72 -18.01 -0.58 5.81e-59 Morning vs. evening chronotype; BRCA cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg19784903 chr17:45786737 TBKBP1 0.34 8.25 0.31 8.93e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2376015 1 rs2376015 chr1:66123774 A/G cg04111102 chr1:66153794 NA 0.36 8.86 0.33 7.84e-18 Fibrinogen levels; BRCA cis rs10193935 0.901 rs7605782 chr2:42502332 C/T cg27598129 chr2:42591480 NA -0.95 -14.52 -0.5 1.78e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs2764980 1.000 rs2764980 chr10:3284007 C/T cg11630169 chr10:3283847 NA 0.41 9.25 0.34 3.27e-19 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs2288073 0.965 rs72789923 chr2:24394504 A/C cg06627628 chr2:24431161 ITSN2 -0.66 -12.11 -0.43 1.48e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg27398817 chr8:82754497 SNX16 -0.37 -8.57 -0.32 7.68e-17 Diastolic blood pressure; BRCA trans rs877282 0.755 rs11253399 chr10:790030 T/A cg22713356 chr15:30763199 NA 1.14 22.57 0.67 2.18e-83 Uric acid levels; BRCA cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs2243480 1.000 rs4718317 chr7:65648901 A/G cg18252515 chr7:66147081 NA 1.0 15.17 0.51 1.35e-44 Diabetic kidney disease; BRCA cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg22601191 chr20:60968625 CABLES2 0.46 10.78 0.39 4.99e-25 Colorectal cancer; BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.21 -0.43 5.68e-31 Gut microbiome composition (summer); BRCA cis rs208520 1.000 rs12190316 chr6:66973365 T/C cg07460842 chr6:66804631 NA 0.69 11.58 0.42 2.68e-28 Exhaled nitric oxide output; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg04025307 chr7:1156635 C7orf50 0.55 13.71 0.48 1.06e-37 Longevity;Endometriosis; BRCA cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11890956 chr21:40555474 PSMG1 0.99 24.13 0.69 5.74e-92 Cognitive function; BRCA cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 13.86 0.48 2.32e-38 Hip circumference adjusted for BMI; BRCA cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg01448562 chr3:133502909 NA -0.39 -8.93 -0.33 4.53e-18 Iron status biomarkers; BRCA cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg00990874 chr7:1149470 C7orf50 -0.49 -10.87 -0.4 2.25e-25 Bronchopulmonary dysplasia; BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg20887711 chr4:1340912 KIAA1530 0.49 11.1 0.4 2.69e-26 Longevity; BRCA cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg20607287 chr7:12443886 VWDE -0.57 -8.09 -0.3 3.08e-15 Coronary artery disease; BRCA cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg19346786 chr7:2764209 NA -0.26 -8.54 -0.32 1.01e-16 Height; BRCA cis rs367943 1.000 rs367943 chr5:112809728 C/T cg12552261 chr5:112820674 MCC 0.55 12.25 0.44 3.85e-31 Type 2 diabetes; BRCA cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.1 0.46 6.54e-35 Electroencephalogram traits; BRCA cis rs473651 0.935 rs558924 chr2:239339511 A/G cg03560586 chr2:239334908 ASB1 -0.41 -7.87 -0.3 1.55e-14 Multiple system atrophy; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg03188948 chr7:1209495 NA 0.82 11.39 0.41 1.8e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg14004847 chr7:1930337 MAD1L1 -0.42 -8.39 -0.32 3.05e-16 Schizophrenia; BRCA trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg15704280 chr7:45808275 SEPT13 0.65 11.44 0.41 1.06e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs698833 0.548 rs6721421 chr2:44535686 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.47 0.32 1.65e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 16.92 0.56 2.33e-53 Platelet count; BRCA cis rs826838 0.967 rs826876 chr12:39123843 T/C cg13010199 chr12:38710504 ALG10B -0.44 -10.35 -0.38 2.55e-23 Heart rate; BRCA cis rs12618769 0.543 rs6753380 chr2:99129040 A/G cg10123293 chr2:99228465 UNC50 0.42 8.26 0.31 8.44e-16 Bipolar disorder; BRCA cis rs600806 0.778 rs11101961 chr1:110008813 T/C cg20591472 chr1:110008990 SYPL2 0.31 7.98 0.3 6.74e-15 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA cis rs796364 0.616 rs769956 chr2:200693720 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.5 -7.95 -0.3 8.6e-15 Schizophrenia; BRCA cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg13880726 chr7:1868755 MAD1L1 0.52 10.54 0.38 4.87e-24 Bipolar disorder and schizophrenia; BRCA cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg24692254 chr21:30365293 RNF160 0.37 8.39 0.31 3.19e-16 Selective IgA deficiency; BRCA cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.06 -0.34 1.62e-18 Menopause (age at onset); BRCA cis rs6745190 0.575 rs55664819 chr2:181980069 T/G cg00481216 chr2:181971175 NA 0.4 9.45 0.35 6.15e-20 White blood cell count; BRCA cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg18016565 chr1:150552671 MCL1 0.36 8.41 0.32 2.75e-16 Tonsillectomy; BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg05457628 chr5:178986728 RUFY1 0.5 12.08 0.43 2.14e-30 Lung cancer; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg26408565 chr15:76604113 ETFA -0.51 -11.6 -0.42 2.19e-28 Blood metabolite levels; BRCA cis rs9487051 0.698 rs35757653 chr6:109644599 A/C cg21918786 chr6:109611834 NA -0.38 -8.31 -0.31 5.63e-16 Reticulocyte fraction of red cells; BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg04709771 chr16:646395 RAB40C 0.42 10.47 0.38 8.88e-24 Height; BRCA cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg13319975 chr6:146136371 FBXO30 0.62 14.44 0.5 4.22e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.41 0.44 8.15e-32 Platelet count; BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg03609598 chr5:56110824 MAP3K1 -0.47 -8.01 -0.3 5.6e-15 Initial pursuit acceleration; BRCA cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg00631329 chr6:26305371 NA -0.42 -12.68 -0.45 5.25e-33 Educational attainment; BRCA cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg20908204 chr19:46285434 DMPK -0.28 -8.13 -0.31 2.18e-15 Coronary artery disease; BRCA cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg08219700 chr8:58056026 NA 0.45 7.87 0.3 1.57e-14 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg22907277 chr7:1156413 C7orf50 0.46 10.7 0.39 1.08e-24 Longevity;Endometriosis; BRCA cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.26e-28 Body mass index; BRCA trans rs10057188 0.742 rs9293756 chr5:77918136 A/C cg11941228 chr5:65891968 MAST4 0.34 8.26 0.31 8.43e-16 Pulse pressure; BRCA cis rs10504073 0.584 rs62507182 chr8:49942500 C/A cg00325661 chr8:49890786 NA 0.49 14.23 0.49 3.9e-40 Blood metabolite ratios; BRCA cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg27478167 chr7:817139 HEATR2 0.49 9.41 0.35 9.07e-20 Cerebrospinal P-tau181p levels; BRCA cis rs1568889 1.000 rs12287732 chr11:28120845 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 13.96 0.48 7.91e-39 Bipolar disorder; BRCA cis rs2985684 0.894 rs2354439 chr14:50019417 G/C cg04989706 chr14:50066350 PPIL5 -0.5 -9.99 -0.37 6.46e-22 Carotid intima media thickness; BRCA cis rs1215050 0.791 rs684210 chr4:98678740 G/C cg05340658 chr4:99064831 C4orf37 0.44 10.07 0.37 3.12e-22 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg15556689 chr8:8085844 FLJ10661 -0.42 -11.05 -0.4 4.42e-26 Neuroticism; BRCA cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg09184832 chr6:79620586 NA -0.52 -11.45 -0.41 9.86e-28 Intelligence (multi-trait analysis); BRCA cis rs250677 0.522 rs55732303 chr5:148392538 C/T cg12140854 chr5:148520817 ABLIM3 -0.41 -8.43 -0.32 2.22e-16 Breast cancer; BRCA cis rs67311347 0.544 rs2278927 chr3:40350447 G/A cg09455208 chr3:40491958 NA 0.35 8.59 0.32 6.75e-17 Renal cell carcinoma; BRCA cis rs11718455 0.960 rs11921995 chr3:44017301 C/A cg08738300 chr3:44038990 NA 0.47 8.86 0.33 8e-18 Coronary artery disease; BRCA cis rs490234 0.746 rs1266009 chr9:128192316 A/G cg14078157 chr9:128172775 NA -0.34 -7.89 -0.3 1.3e-14 Mean arterial pressure; BRCA cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.53 0.5 1.53e-41 Motion sickness; BRCA trans rs6598955 0.671 rs57386998 chr1:26569821 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA trans rs35110281 0.667 rs4819286 chr21:45120121 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.66 0.32 3.77e-17 Mean corpuscular volume; BRCA cis rs11190604 1.000 rs2489047 chr10:102347028 A/G cg07080220 chr10:102295463 HIF1AN 0.51 11.73 0.42 6.43e-29 Palmitoleic acid (16:1n-7) levels; BRCA trans rs61931739 0.534 rs10844800 chr12:34230734 A/G cg26384229 chr12:38710491 ALG10B 0.67 14.33 0.49 1.43e-40 Morning vs. evening chronotype; BRCA cis rs56399783 0.901 rs73047393 chr7:2775879 C/T cg19731401 chr7:2775893 GNA12 0.52 8.24 0.31 9.73e-16 Childhood ear infection; BRCA cis rs743757 1.000 rs2282754 chr3:50436827 T/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.45 8.14 0.31 2.12e-15 Diastolic blood pressure; BRCA trans rs11098499 0.866 rs13105020 chr4:120285688 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg11663144 chr21:46675770 NA -0.61 -14.22 -0.49 4.45e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs637571 0.510 rs3892696 chr11:65582341 G/C cg17712092 chr4:129076599 LARP1B -0.52 -11.66 -0.42 1.26e-28 Eosinophil percentage of white cells; BRCA cis rs9287719 0.839 rs7600695 chr2:10739945 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs9796 0.558 rs7166205 chr15:41514733 A/G cg18705301 chr15:41695430 NDUFAF1 -0.36 -7.85 -0.3 1.76e-14 Menopause (age at onset); BRCA cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg27398817 chr8:82754497 SNX16 0.44 8.66 0.32 3.76e-17 Diastolic blood pressure; BRCA trans rs12517041 1.000 rs7723641 chr5:23298305 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.44 -8.07 -0.3 3.61e-15 Calcium levels; BRCA cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06022373 chr22:39101656 GTPBP1 -0.73 -15.82 -0.53 7.82e-48 Menopause (age at onset); BRCA cis rs9818758 0.556 rs9813813 chr3:49207093 T/A cg00383909 chr3:49044727 WDR6 0.96 14.94 0.51 1.61e-43 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs12618769 0.597 rs4850879 chr2:99113082 A/G cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs8014204 1.000 rs10483863 chr14:75322327 A/G cg06637938 chr14:75390232 RPS6KL1 -0.51 -10.64 -0.39 1.79e-24 Caffeine consumption; BRCA cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg00990874 chr7:1149470 C7orf50 -0.51 -9.93 -0.37 1.08e-21 Bronchopulmonary dysplasia; BRCA cis rs6500602 0.893 rs6500596 chr16:4470027 G/T cg08645402 chr16:4508243 NA 0.39 8.4 0.32 2.8e-16 Schizophrenia; BRCA cis rs838147 0.760 rs281408 chr19:49233406 A/C cg12258179 chr19:49232187 RASIP1 -0.32 -8.02 -0.3 4.9e-15 Dietary macronutrient intake; BRCA cis rs9942416 0.660 rs41534344 chr5:74997832 T/C cg19683494 chr5:74908142 NA 0.48 8.93 0.33 4.33e-18 Age-related disease endophenotypes; BRCA cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg24812749 chr6:127587940 RNF146 0.69 15.72 0.53 2.58e-47 Breast cancer; BRCA cis rs61931739 0.534 rs11053016 chr12:34104372 C/T cg06521331 chr12:34319734 NA -0.62 -11.18 -0.4 1.22e-26 Morning vs. evening chronotype; BRCA cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg01448562 chr3:133502909 NA -0.61 -14.38 -0.49 7.95e-41 Iron status biomarkers; BRCA cis rs7246657 0.722 rs10417576 chr19:38119212 A/C cg14683738 chr19:37701593 ZNF585B 0.47 8.11 0.31 2.51e-15 Coronary artery calcification; BRCA trans rs7618501 0.699 rs1317154 chr3:49910084 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.37 10.28 0.38 4.82e-23 Intelligence (multi-trait analysis); BRCA cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg04117972 chr1:227635322 NA 0.52 9.28 0.34 2.55e-19 Major depressive disorder; BRCA cis rs6910061 1.000 rs36067344 chr6:11094764 C/T cg27233058 chr6:11094804 LOC221710 0.53 9.39 0.35 1.01e-19 Diabetic kidney disease; BRCA cis rs6546550 0.868 rs12713682 chr2:70154134 G/A cg02498382 chr2:70120550 SNRNP27 -0.52 -11.34 -0.41 2.86e-27 Prevalent atrial fibrillation; BRCA cis rs1712517 0.873 rs7903004 chr10:105004101 G/A cg05636881 chr10:105038444 INA -0.35 -7.94 -0.3 9.06e-15 Migraine; BRCA cis rs7592578 0.766 rs62182885 chr2:191437024 A/G cg11845111 chr2:191398756 TMEM194B -0.82 -14.72 -0.5 1.92e-42 Diastolic blood pressure; BRCA cis rs57590327 0.503 rs6802480 chr3:81906671 G/A cg07356753 chr3:81810745 GBE1 -0.44 -10.06 -0.37 3.41e-22 Extraversion; BRCA cis rs10504073 0.647 rs59064792 chr8:50018337 A/C cg00325661 chr8:49890786 NA 0.38 11.26 0.41 5.95e-27 Blood metabolite ratios; BRCA trans rs6952808 1.000 rs4449693 chr7:1884630 G/C cg04565464 chr8:145669602 NFKBIL2 0.36 7.91 0.3 1.13e-14 Bipolar disorder and schizophrenia; BRCA cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg21918786 chr6:109611834 NA -0.36 -9.71 -0.36 7.07e-21 Reticulocyte fraction of red cells; BRCA cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg26395211 chr5:140044315 WDR55 -0.37 -8.32 -0.31 5.39e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg03354898 chr7:1950403 MAD1L1 -0.37 -7.9 -0.3 1.23e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg12311346 chr5:56204834 C5orf35 -0.73 -14.47 -0.5 3.11e-41 Initial pursuit acceleration; BRCA cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg26597838 chr10:835615 NA 0.97 17.04 0.56 6.2e-54 Eosinophil percentage of granulocytes; BRCA cis rs7523050 0.643 rs34920128 chr1:109400889 C/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.66 -0.59 2.46e-62 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.59 0.55 1.2e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.8 0.51 7.85e-43 Colorectal cancer; BRCA cis rs9649465 0.561 rs2429621 chr7:123430316 A/G cg03229431 chr7:123269106 ASB15 0.41 9.47 0.35 5.49e-20 Migraine; BRCA cis rs1801251 1.000 rs2012221 chr2:233566848 T/C cg25237894 chr2:233734115 C2orf82 0.38 11.12 0.4 2.2e-26 Coronary artery disease; BRCA trans rs11098499 0.954 rs1546505 chr4:120241224 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.43 0.32 2.32e-16 Corneal astigmatism; BRCA cis rs35306767 0.623 rs36051896 chr10:1155747 T/C cg20503657 chr10:835505 NA 0.68 10.8 0.39 4.43e-25 Eosinophil percentage of granulocytes; BRCA trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg15934090 chr1:100435551 SLC35A3 0.37 8.27 0.31 7.71e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.1 -0.31 2.84e-15 Depression; BRCA cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg06064525 chr11:970664 AP2A2 -0.47 -15.53 -0.52 2.32e-46 Alzheimer's disease (late onset); BRCA cis rs2425143 1.000 rs1056196 chr20:34327159 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg03433033 chr1:76189801 ACADM 0.76 17.39 0.57 9.52e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7267979 1.000 rs3002702 chr20:25268920 T/C cg08601574 chr20:25228251 PYGB 0.35 8.48 0.32 1.61e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7737355 1.000 rs257390 chr5:130740617 C/T cg06307176 chr5:131281290 NA -0.48 -9.38 -0.35 1.1e-19 Life satisfaction; BRCA cis rs2637266 1.000 rs7477433 chr10:78358116 C/T cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.6 -0.35 1.83e-20 Mean corpuscular volume; BRCA cis rs3806843 1.000 rs6579987 chr5:140183659 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs66887589 0.967 rs13104219 chr4:120438174 G/T cg09307838 chr4:120376055 NA 0.46 9.56 0.35 2.53e-20 Diastolic blood pressure; BRCA cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg01475377 chr6:109611718 NA -0.56 -15.06 -0.51 4.35e-44 Reticulocyte fraction of red cells; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.34 -0.31 4.42e-16 Total body bone mineral density; BRCA cis rs9649465 0.935 rs3815458 chr7:123304323 A/T cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.66e-16 Migraine; BRCA trans rs11039798 0.841 rs11039760 chr11:48479009 C/T cg15704280 chr7:45808275 SEPT13 0.69 8.22 0.31 1.16e-15 Axial length; BRCA cis rs3768617 0.510 rs4651145 chr1:183098900 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs3820068 0.603 rs6429769 chr1:15968610 C/G cg17385448 chr1:15911702 AGMAT 0.35 7.95 0.3 8.17e-15 Systolic blood pressure; BRCA cis rs701145 0.585 rs62276840 chr3:153783622 G/C cg17054900 chr3:154042577 DHX36 -0.54 -9.14 -0.34 7.93e-19 Coronary artery disease; BRCA cis rs7809950 1.000 rs12667527 chr7:107086969 T/C cg23024343 chr7:107201750 COG5 -0.42 -9.67 -0.36 1.02e-20 Coronary artery disease; BRCA trans rs7647973 0.710 rs11130208 chr3:49615624 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.86 -0.3 1.65e-14 Menarche (age at onset); BRCA cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg25208724 chr1:156163844 SLC25A44 1.05 33.53 0.8 5.46e-143 Testicular germ cell tumor; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg16590910 chr6:42928470 GNMT 0.36 7.87 0.3 1.54e-14 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg04450456 chr4:17643702 FAM184B 0.35 9.42 0.35 8.36e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg08999081 chr20:33150536 PIGU 0.47 12.95 0.46 3.15e-34 Glomerular filtration rate (creatinine); BRCA cis rs6121246 0.512 rs6060941 chr20:30367383 C/T cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg25482853 chr8:67687455 SGK3 1.05 16.94 0.56 1.94e-53 Lung disease severity in cystic fibrosis; BRCA cis rs6582630 0.524 rs10785494 chr12:38532431 C/G cg26384229 chr12:38710491 ALG10B -0.43 -10.11 -0.37 2.08e-22 Drug-induced liver injury (flucloxacillin); BRCA trans rs7647973 0.626 rs9835157 chr3:49797769 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.4 8.13 0.31 2.22e-15 Menarche (age at onset); BRCA cis rs68170813 0.559 rs7800443 chr7:106910723 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.61 -0.32 5.62e-17 Coronary artery disease; BRCA cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg13010199 chr12:38710504 ALG10B 0.44 8.97 0.33 3.33e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.51 12.17 0.43 8.78e-31 Electrocardiographic conduction measures; BRCA cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg24642439 chr20:33292090 TP53INP2 0.61 13.43 0.47 2.21e-36 Coronary artery disease; BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg04944784 chr2:26401820 FAM59B -0.84 -13.23 -0.46 1.74e-35 Gut microbiome composition (summer); BRCA cis rs67340775 0.541 rs200964 chr6:27866943 G/C cg26587870 chr6:27730563 NA -0.44 -7.84 -0.3 1.84e-14 Lung cancer in ever smokers; BRCA cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg12923728 chr3:195709715 SDHAP1 -0.58 -12.41 -0.44 7.61e-32 Pancreatic cancer; BRCA cis rs250677 0.687 rs36048 chr5:148441713 G/C cg23229984 chr5:148520753 ABLIM3 0.35 8.64 0.32 4.48e-17 Breast cancer; BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg16606324 chr3:10149918 C3orf24 0.51 10.15 0.37 1.52e-22 Alzheimer's disease; BRCA trans rs11098499 0.909 rs1546502 chr4:120235898 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.12 0.31 2.33e-15 Corneal astigmatism; BRCA cis rs17401966 1.000 rs17410793 chr1:10391886 A/G cg03954927 chr1:10346856 KIF1B 0.47 13.17 0.46 3.22e-35 Hepatocellular carcinoma; BRCA cis rs6942407 0.546 rs2074757 chr7:86794121 G/A cg02420886 chr7:86849541 C7orf23 0.54 8.1 0.31 2.73e-15 Food allergy; BRCA cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg08508325 chr11:3079039 CARS -0.42 -14.39 -0.49 7.51e-41 Longevity; BRCA cis rs7918232 0.943 rs6482593 chr10:27371437 A/G cg14442939 chr10:27389572 ANKRD26 0.69 11.53 0.42 4.38e-28 Breast cancer; BRCA cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg15605315 chr1:45957053 TESK2 -0.44 -8.88 -0.33 6.59e-18 High light scatter reticulocyte count; BRCA cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg08885076 chr2:99613938 TSGA10 -0.6 -13.6 -0.47 3.48e-37 Chronic sinus infection; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg00149659 chr3:10157352 C3orf10 1.08 18.1 0.58 1.93e-59 Alzheimer's disease; BRCA cis rs7927771 0.690 rs35496532 chr11:47450338 C/T cg20307385 chr11:47447363 PSMC3 -0.43 -9.14 -0.34 8.4e-19 Subjective well-being; BRCA cis rs7178572 0.743 rs62009090 chr15:77837055 T/G cg22256960 chr15:77711686 NA -0.38 -8.26 -0.31 8.65e-16 Type 2 diabetes; BRCA cis rs9790314 0.589 rs4679662 chr3:160603024 T/C cg03342759 chr3:160939853 NMD3 0.41 8.17 0.31 1.69e-15 Morning vs. evening chronotype; BRCA cis rs7772486 0.686 rs9403739 chr6:146015357 A/G cg23711669 chr6:146136114 FBXO30 -0.69 -15.97 -0.53 1.4e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs6977660 0.714 rs17141882 chr7:19790217 C/T cg07541023 chr7:19748670 TWISTNB 0.57 9.79 0.36 3.53e-21 Thyroid stimulating hormone; BRCA cis rs12989701 0.825 rs4663096 chr2:127861766 T/A cg08168897 chr2:127865431 BIN1 0.6 10.95 0.4 1.1e-25 Alzheimer's disease (late onset); BRCA cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg14844989 chr11:31128820 NA 0.44 9.82 0.36 2.67e-21 Red blood cell count; BRCA cis rs7727544 0.582 rs3792894 chr5:131547271 C/T cg14196790 chr5:131705035 SLC22A5 0.34 8.89 0.33 5.99e-18 Blood metabolite levels; BRCA cis rs6901250 0.655 rs636252 chr6:117157774 A/G cg12892004 chr6:117198278 RFX6 -0.38 -9.4 -0.35 9.27e-20 C-reactive protein levels; BRCA cis rs17818399 0.597 rs13385693 chr2:46867158 C/T cg02822958 chr2:46747628 ATP6V1E2 0.41 7.99 0.3 6.3e-15 Height; BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg14789911 chr21:47582049 C21orf56 -0.36 -7.92 -0.3 1.04e-14 Testicular germ cell tumor; BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg16606324 chr3:10149918 C3orf24 0.56 11.2 0.41 1.01e-26 Alzheimer's disease; BRCA cis rs589448 0.902 rs315138 chr12:69764850 A/T cg14784868 chr12:69753453 YEATS4 0.78 25.12 0.7 2.27e-97 Cerebrospinal fluid biomarker levels; BRCA trans rs9467711 0.659 rs66757203 chr6:26454956 C/T cg01620082 chr3:125678407 NA -0.71 -8.39 -0.32 3.09e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6740322 0.948 rs6722694 chr2:43569798 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.78 -0.45 1.85e-33 Coronary artery disease; BRCA cis rs4891159 0.790 rs10514217 chr18:74144939 A/G cg24786174 chr18:74118243 ZNF516 -0.69 -16.61 -0.55 8.92e-52 Longevity; BRCA cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11890956 chr21:40555474 PSMG1 0.82 20.46 0.63 6.03e-72 Cognitive function; BRCA trans rs9944715 0.954 rs6507676 chr18:43739730 T/C cg01718231 chr17:29326311 RNF135 0.44 8.92 0.33 5.02e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs1113500 0.814 rs893983 chr1:108630338 C/T cg06207961 chr1:108661230 NA -0.35 -8.65 -0.32 4.06e-17 Growth-regulated protein alpha levels; BRCA cis rs1468333 0.964 rs2967786 chr5:137547675 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.42 8.58 0.32 7.31e-17 Resting heart rate; BRCA cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg10932868 chr11:921992 NA 0.49 12.66 0.45 5.96e-33 Alzheimer's disease (late onset); BRCA cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.57 -0.42 3.19e-28 Bipolar disorder; BRCA cis rs7246657 0.943 rs13343471 chr19:37932130 A/G cg18154014 chr19:37997991 ZNF793 0.65 11.84 0.42 2.15e-29 Coronary artery calcification; BRCA cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg15083037 chr5:83017644 HAPLN1 -0.52 -10.1 -0.37 2.31e-22 Prostate cancer; BRCA cis rs4478858 0.735 rs4622114 chr1:31772571 A/G cg00250761 chr1:31883323 NA -0.32 -8.25 -0.31 9.14e-16 Alcohol dependence; BRCA cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg25427524 chr10:38739819 LOC399744 -0.64 -15.4 -0.52 9.88e-46 Extrinsic epigenetic age acceleration; BRCA cis rs4285028 0.747 rs1127412 chr3:121414061 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.69 -13.75 -0.48 7.15e-38 Multiple sclerosis; BRCA cis rs9796 0.621 rs7170049 chr15:41484287 C/A cg18705301 chr15:41695430 NDUFAF1 -0.37 -7.83 -0.3 2.04e-14 Menopause (age at onset); BRCA cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg14664628 chr15:75095509 CSK 0.72 17.95 0.58 1.16e-58 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10493773 0.775 rs2069208 chr1:86117583 T/C cg17807903 chr1:86174739 ZNHIT6 -0.46 -10.47 -0.38 8.44e-24 Urate levels in overweight individuals; BRCA cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg17211192 chr8:82754475 SNX16 0.52 11.9 0.43 1.23e-29 Diastolic blood pressure; BRCA cis rs7565124 0.909 rs6747472 chr2:20252007 C/T cg23821541 chr2:20251993 LAPTM4A 0.39 8.23 0.31 1.02e-15 Major depressive disorder; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00166722 chr3:10149974 C3orf24 0.67 13.44 0.47 1.83e-36 Alzheimer's disease; BRCA cis rs9467711 0.538 rs36012762 chr6:25980523 A/C cg08501292 chr6:25962987 TRIM38 0.59 8.02 0.3 4.97e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs295140 0.546 rs295134 chr2:201110223 A/G cg23649088 chr2:200775458 C2orf69 -0.41 -8.76 -0.33 1.81e-17 QT interval; BRCA cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.5 0.5 2.04e-41 Colorectal cancer; BRCA cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.54e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg14863265 chr7:2801509 GNA12 -0.39 -8.97 -0.33 3.21e-18 Height; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg08888203 chr3:10149979 C3orf24 0.67 14.48 0.5 2.56e-41 Alzheimer's disease; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg05552183 chr6:42928497 GNMT 0.79 19.21 0.6 3.07e-65 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg01579765 chr21:45077557 HSF2BP -0.38 -10.27 -0.38 5.11e-23 Mean corpuscular volume; BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg22920501 chr2:26401640 FAM59B -0.8 -13.18 -0.46 3e-35 Gut microbiome composition (summer); BRCA cis rs250677 0.522 rs7702695 chr5:148402550 T/A cg12140854 chr5:148520817 ABLIM3 -0.42 -8.52 -0.32 1.12e-16 Breast cancer; BRCA cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs832540 0.629 rs3309 chr5:56092779 A/T cg22800045 chr5:56110881 MAP3K1 -0.4 -8.25 -0.31 9.3e-16 Coronary artery disease; BRCA cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.69 -0.5 2.63e-42 Total cholesterol levels; BRCA cis rs9790314 1.000 rs464766 chr3:161087592 C/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.92 -0.51 2.15e-43 Morning vs. evening chronotype; BRCA cis rs3820928 0.904 rs2396431 chr2:227765488 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.77e-16 Pulmonary function; BRCA cis rs208520 0.526 rs9354370 chr6:66808209 C/T cg07460842 chr6:66804631 NA 1.15 37.82 0.83 3.38e-165 Exhaled nitric oxide output; BRCA cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.67 -0.45 5.66e-33 Bipolar disorder; BRCA cis rs2415984 0.622 rs61993303 chr14:46949716 G/C cg14871534 chr14:47121158 RPL10L -0.33 -8.2 -0.31 1.35e-15 Number of children ever born; BRCA cis rs4423214 0.840 rs2017686 chr11:71187061 C/G cg05163923 chr11:71159392 DHCR7 -0.56 -11.35 -0.41 2.58e-27 Vitamin D levels; BRCA cis rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05901451 chr6:126070800 HEY2 0.4 9.7 0.36 7.76e-21 Endometrial cancer; BRCA cis rs6545883 0.507 rs2123111 chr2:61450454 A/G cg15711740 chr2:61764176 XPO1 0.32 8.04 0.3 4.39e-15 Tuberculosis; BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg26314531 chr2:26401878 FAM59B -0.97 -16.81 -0.55 9.01e-53 Gut microbiome composition (summer); BRCA trans rs8002861 0.664 rs9533662 chr13:44435988 T/A cg17145862 chr1:211918768 LPGAT1 0.47 10.77 0.39 5.47e-25 Leprosy; BRCA trans rs8002861 0.664 rs1808097 chr13:44424766 A/G cg17145862 chr1:211918768 LPGAT1 0.47 10.77 0.39 5.77e-25 Leprosy; BRCA cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg21138405 chr5:131827807 IRF1 0.4 13.0 0.46 1.85e-34 Asthma (sex interaction); BRCA cis rs243505 1.000 rs1019058 chr7:148424243 A/G cg09806900 chr7:148480153 CUL1 -0.43 -8.81 -0.33 1.15e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6089584 0.507 rs6061990 chr20:60628429 T/G cg06108461 chr20:60628389 TAF4 -0.69 -14.42 -0.5 5.25e-41 Body mass index; BRCA cis rs10911232 0.507 rs4652764 chr1:182994115 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.35 0.54 1.78e-50 Hypertriglyceridemia; BRCA cis rs2859741 1.000 rs2795009 chr1:37509494 C/T cg09363841 chr1:37513479 NA -0.67 -16.68 -0.55 4.16e-52 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg24642439 chr20:33292090 TP53INP2 -0.52 -11.5 -0.41 6.15e-28 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg05313129 chr8:58192883 C8orf71 -0.46 -9.46 -0.35 5.73e-20 Developmental language disorder (linguistic errors); BRCA cis rs6138458 1.000 rs227618 chr20:24909472 T/C cg26195577 chr20:24973756 C20orf3 0.99 24.7 0.7 4.74e-95 Blood protein levels; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg14062083 chr21:31802829 KRTAP13-4 0.33 8.78 0.33 1.46e-17 HDL cholesterol; BRCA cis rs116979167 0.545 rs1706914 chr7:105196445 A/T cg19920283 chr7:105172520 RINT1 0.44 8.95 0.33 3.92e-18 Bipolar disorder (body mass index interaction); BRCA trans rs6582630 0.519 rs11182457 chr12:38538331 G/A cg06521331 chr12:34319734 NA -0.51 -9.27 -0.34 2.72e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1865760 1.000 rs2071299 chr6:25914801 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.41 0.38 1.49e-23 Height; BRCA trans rs10028773 0.515 rs9994488 chr4:120587781 C/T cg25214090 chr10:38739885 LOC399744 0.42 9.45 0.35 6.21e-20 Educational attainment; BRCA cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg11644478 chr21:40555479 PSMG1 0.86 19.84 0.62 1.25e-68 Cognitive function; BRCA cis rs2839186 0.900 rs59828751 chr21:47708918 A/G cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs2797160 0.874 rs58305111 chr6:126008386 G/T cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.19e-20 Endometrial cancer; BRCA cis rs6987853 0.787 rs2974346 chr8:42401205 T/C cg09913449 chr8:42400586 C8orf40 0.41 9.08 0.34 1.35e-18 Mean corpuscular hemoglobin concentration; BRCA cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg06784218 chr1:46089804 CCDC17 -0.53 -12.92 -0.45 4.51e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg05347473 chr6:146136440 FBXO30 0.42 8.46 0.32 1.78e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11785693 0.862 rs10503292 chr8:4992275 A/G cg26367366 chr8:4980734 NA 0.47 8.11 0.31 2.6e-15 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg27478167 chr7:817139 HEATR2 -0.48 -9.89 -0.36 1.52e-21 Cerebrospinal P-tau181p levels; BRCA cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg00071950 chr4:10020882 SLC2A9 -0.47 -10.89 -0.4 1.85e-25 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7824557 0.767 rs28507159 chr8:11166076 C/T cg08975724 chr8:8085496 FLJ10661 0.43 8.0 0.3 5.9e-15 Retinal vascular caliber; BRCA trans rs60843830 1.000 rs10193373 chr2:281886 T/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.8 0.51 8.09e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6942756 1.000 rs66970518 chr7:128871006 G/A cg02491457 chr7:128862824 NA -0.71 -14.34 -0.49 1.22e-40 White matter hyperintensity burden; BRCA cis rs7178424 0.742 rs7170293 chr15:62236373 A/T cg00456672 chr15:62358751 C2CD4A 0.41 9.93 0.37 1.02e-21 Height; BRCA cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24308560 chr3:49941425 MST1R 0.39 8.3 0.31 6.01e-16 Intelligence (multi-trait analysis); BRCA cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.13 -0.49 1.2e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs459571 0.959 rs416390 chr9:136908549 C/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.81 15.71 0.53 2.85e-47 Platelet distribution width; BRCA cis rs34779708 0.898 rs11595898 chr10:35326263 T/C cg03585969 chr10:35415529 CREM 0.55 11.39 0.41 1.72e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg15112475 chr7:1198522 ZFAND2A -0.38 -8.33 -0.31 4.87e-16 Longevity;Endometriosis; BRCA cis rs12310956 0.532 rs11052933 chr12:33969881 G/A cg06521331 chr12:34319734 NA -0.6 -11.02 -0.4 5.61e-26 Morning vs. evening chronotype; BRCA cis rs3806843 0.868 rs2563291 chr5:140119599 T/A cg26395211 chr5:140044315 WDR55 0.34 7.84 0.3 1.84e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg23711669 chr6:146136114 FBXO30 -0.76 -17.46 -0.57 4.11e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -9.31 -0.35 2.01e-19 Personality dimensions; BRCA cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg11764359 chr7:65958608 NA -0.73 -16.08 -0.54 3.99e-49 Aortic root size; BRCA cis rs2635047 0.967 rs2684843 chr18:44726260 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 8.15 0.31 1.97e-15 Educational attainment; BRCA cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg26384229 chr12:38710491 ALG10B 0.77 17.64 0.57 4.77e-57 Drug-induced liver injury (flucloxacillin); BRCA trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg26384229 chr12:38710491 ALG10B 0.59 13.53 0.47 7.42e-37 Morning vs. evening chronotype; BRCA cis rs3806843 0.868 rs2563281 chr5:140131219 T/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.16 0.34 7.11e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs939658 0.683 rs8041222 chr15:79465549 A/G cg17916960 chr15:79447300 NA -0.36 -8.71 -0.33 2.69e-17 Refractive error; BRCA cis rs1003719 0.715 rs6517405 chr21:38560334 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA trans rs984440 0.524 rs10111139 chr8:139084283 C/T cg03334052 chr1:168888044 NA -0.37 -8.53 -0.32 1.1e-16 Obesity-related traits; BRCA cis rs6752107 0.935 rs10199278 chr2:234160669 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.33 0.41 2.94e-27 Crohn's disease;Inflammatory bowel disease; BRCA trans rs8002861 0.840 rs7989353 chr13:44438957 T/C cg17145862 chr1:211918768 LPGAT1 0.63 16.18 0.54 1.31e-49 Leprosy; BRCA cis rs701145 0.585 rs1470662 chr3:153870997 T/G cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg23992470 chr4:843637 GAK 0.56 8.34 0.31 4.4e-16 Intelligence (multi-trait analysis); BRCA trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg03929089 chr4:120376271 NA -0.71 -14.17 -0.49 7.75e-40 Height; BRCA cis rs10046574 0.831 rs10251162 chr7:135190264 C/T cg27474649 chr7:135195673 CNOT4 0.64 9.17 0.34 6.38e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg11608241 chr8:8085544 FLJ10661 0.3 8.12 0.31 2.38e-15 Mood instability; BRCA cis rs6912958 0.559 rs107690 chr6:88069352 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.37 -10.81 -0.39 3.96e-25 Monocyte percentage of white cells; BRCA cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg08917208 chr2:24149416 ATAD2B 0.51 8.16 0.31 1.81e-15 Asthma; BRCA cis rs9487051 0.773 rs421790 chr6:109543428 T/A cg21918786 chr6:109611834 NA -0.35 -8.61 -0.32 5.78e-17 Reticulocyte fraction of red cells; BRCA cis rs7582720 0.943 rs72934550 chr2:203983940 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.77 0.45 2.02e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18758796 chr5:131593413 PDLIM4 -0.41 -10.83 -0.39 3.32e-25 Acylcarnitine levels; BRCA cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg21535247 chr6:8435926 SLC35B3 0.38 8.39 0.32 3.1e-16 Motion sickness; BRCA cis rs10504073 0.584 rs55795863 chr8:49898055 A/G cg00325661 chr8:49890786 NA 0.52 15.1 0.51 2.79e-44 Blood metabolite ratios; BRCA cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg08999081 chr20:33150536 PIGU 0.35 9.04 0.34 1.86e-18 Coronary artery disease; BRCA cis rs9517320 0.534 rs9556963 chr13:99157026 G/A cg07423050 chr13:99094983 FARP1 -0.49 -10.83 -0.39 3.37e-25 Longevity; BRCA cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg24692254 chr21:30365293 RNF160 -0.45 -9.98 -0.37 6.8e-22 Pancreatic cancer; BRCA cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg01283332 chr5:1856932 NA -0.33 -8.01 -0.3 5.39e-15 Cardiovascular disease risk factors; BRCA cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 1.97e-48 Bladder cancer; BRCA trans rs7980799 0.716 rs10161311 chr12:33623204 G/A cg26384229 chr12:38710491 ALG10B -0.51 -10.97 -0.4 8.96e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs3768617 0.510 rs2224933 chr1:183095765 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs7809950 1.000 rs10273733 chr7:107258121 A/G cg23024343 chr7:107201750 COG5 0.39 8.38 0.31 3.36e-16 Coronary artery disease; BRCA cis rs637571 0.522 rs606978 chr11:65711517 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.61 12.97 0.46 2.54e-34 Eosinophil percentage of white cells; BRCA cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.03 0.56 6.82e-54 Bladder cancer; BRCA cis rs13136331 0.721 rs2732175 chr4:88682574 C/G cg22416721 chr4:88570574 DMP1 -0.52 -12.29 -0.44 2.52e-31 Sitting height ratio; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6835174 0.881 rs4516655 chr4:5975378 G/A cg08509927 chr4:5976063 C4orf50 -0.52 -8.56 -0.32 8.23e-17 Cannabis use (initiation); BRCA cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg16325326 chr1:53192061 ZYG11B -0.66 -16.28 -0.54 4.37e-50 Monocyte count; BRCA cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg18016565 chr1:150552671 MCL1 -0.34 -8.11 -0.31 2.5e-15 Tonsillectomy; BRCA cis rs17376456 0.569 rs7729807 chr5:93104089 C/T cg25358565 chr5:93447407 FAM172A 0.69 11.97 0.43 6.3e-30 Diabetic retinopathy; BRCA cis rs12949688 0.967 rs9910446 chr17:55821485 G/C cg12582317 chr17:55822272 NA 0.32 7.93 0.3 9.68e-15 Schizophrenia; BRCA cis rs8062405 1.000 rs7205323 chr16:28865892 C/T cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.71 -16.93 -0.56 2.1e-53 Chronic sinus infection; BRCA cis rs73198271 0.562 rs17154743 chr8:8650787 A/G cg01851573 chr8:8652454 MFHAS1 0.49 9.3 0.35 2.21e-19 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs208520 0.690 rs1100981 chr6:66852052 T/C cg07460842 chr6:66804631 NA -1.02 -20.26 -0.63 7.39e-71 Exhaled nitric oxide output; BRCA cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg24399712 chr22:39784796 NA 0.54 12.36 0.44 1.34e-31 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs12618769 0.597 rs4851138 chr2:99065464 A/C cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.71e-15 Bipolar disorder; BRCA cis rs30380 0.666 rs26512 chr5:96128400 G/T cg16492584 chr5:96139282 ERAP1 -0.46 -10.93 -0.4 1.25e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs4285028 0.747 rs6791882 chr3:121373058 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.82 -15.88 -0.53 4.21e-48 Multiple sclerosis; BRCA cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -9.5 -0.35 4.26e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg10862848 chr6:42927986 GNMT -0.35 -14.62 -0.5 5.61e-42 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg19346786 chr7:2764209 NA -0.33 -9.84 -0.36 2.22e-21 Height; BRCA trans rs6951245 1.000 rs77702926 chr7:1088838 G/A cg13565492 chr6:43139072 SRF -0.79 -10.84 -0.39 2.99e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12541635 0.639 rs6469030 chr8:107030321 C/T cg10147462 chr8:107024639 NA 0.38 9.97 0.37 7.2e-22 Age of smoking initiation; BRCA cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg27286337 chr10:134555280 INPP5A 0.8 12.94 0.46 3.49e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9815354 0.680 rs73073263 chr3:42018666 C/A cg03022575 chr3:42003672 ULK4 0.77 9.77 0.36 4e-21 Pulse pressure;Diastolic blood pressure; BRCA trans rs6598955 0.572 rs12089219 chr1:26638751 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.46 -0.52 5.17e-46 Obesity-related traits; BRCA trans rs7824557 0.767 rs3808513 chr8:11157460 G/T cg15556689 chr8:8085844 FLJ10661 -0.39 -9.38 -0.35 1.12e-19 Retinal vascular caliber; BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs2806561 1.000 rs2473851 chr1:23489869 A/G cg19743168 chr1:23544995 NA 0.4 9.6 0.36 1.72e-20 Height; BRCA trans rs783540 0.609 rs803686 chr15:83219340 G/A cg18393722 chr15:85113863 UBE2QP1 -0.32 -8.5 -0.32 1.31e-16 Schizophrenia; BRCA cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.05 0.3 4.15e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.12 -0.37 1.97e-22 IgG glycosylation; BRCA cis rs13095912 0.597 rs112800013 chr3:185313807 A/G cg11274856 chr3:185301563 NA 0.52 12.35 0.44 1.46e-31 Systolic blood pressure; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg05793240 chr7:2802953 GNA12 0.31 7.99 0.3 6.14e-15 Height; BRCA cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg11742103 chr11:62369870 EML3;MTA2 0.54 11.43 0.41 1.18e-27 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg12463550 chr7:65579703 CRCP 0.38 8.09 0.3 2.99e-15 Aortic root size; BRCA trans rs7939886 0.920 rs12223014 chr11:55878290 G/A cg15704280 chr7:45808275 SEPT13 0.61 7.98 0.3 6.74e-15 Myopia (pathological); BRCA trans rs11098499 1.000 rs1011054 chr4:120202387 A/G cg25214090 chr10:38739885 LOC399744 -0.48 -10.23 -0.38 7.19e-23 Corneal astigmatism; BRCA trans rs11039798 0.920 rs11039848 chr11:48598243 C/T cg15704280 chr7:45808275 SEPT13 0.64 7.82 0.3 2.12e-14 Axial length; BRCA cis rs6582630 0.519 rs11520262 chr12:38333051 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.37 0.38 2.25e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2274471 0.645 rs73395330 chr9:5082839 C/T cg03390472 chr9:5043263 JAK2 -0.49 -8.86 -0.33 7.63e-18 Crohn's disease; BRCA cis rs738322 0.804 rs4821742 chr22:38514839 T/C cg20207973 chr22:38506712 BAIAP2L2 0.39 9.82 0.36 2.79e-21 Cutaneous nevi; BRCA cis rs1003719 0.646 rs2835671 chr21:38581125 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.51 -0.5 1.83e-41 Eye color traits; BRCA cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg26384229 chr12:38710491 ALG10B -0.55 -13.58 -0.47 4.27e-37 Morning vs. evening chronotype; BRCA cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg13010199 chr12:38710504 ALG10B -0.43 -9.88 -0.36 1.68e-21 Heart rate; BRCA cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg06640241 chr16:89574553 SPG7 0.84 20.91 0.64 2.41e-74 Multiple myeloma (IgH translocation); BRCA cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg03264133 chr6:25882463 NA -0.61 -12.65 -0.45 6.79e-33 Intelligence (multi-trait analysis); BRCA trans rs9858542 0.953 rs11922013 chr3:49458355 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.4 -0.35 9.2e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -9.75 -0.36 5.15e-21 Joint mobility (Beighton score); BRCA cis rs11758351 0.866 rs2069018 chr6:26205718 T/C cg01420254 chr6:26195488 NA 0.55 8.49 0.32 1.49e-16 Gout;Renal underexcretion gout; BRCA cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.06 -0.3 3.78e-15 Bipolar disorder; BRCA cis rs12618769 0.652 rs3754878 chr2:99179384 G/A cg10123293 chr2:99228465 UNC50 0.44 8.67 0.32 3.42e-17 Bipolar disorder; BRCA cis rs965469 0.779 rs6037528 chr20:3260978 A/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.72 -0.33 2.31e-17 IFN-related cytopenia; BRCA cis rs7264396 0.563 rs6060580 chr20:34310512 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.13 -0.43 1.26e-30 Total cholesterol levels; BRCA cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg26373071 chr5:1325741 CLPTM1L 0.5 12.26 0.44 3.6e-31 Lung cancer; BRCA cis rs208520 0.690 rs207077 chr6:66769855 A/C cg07460842 chr6:66804631 NA -1.01 -19.86 -0.62 9.57e-69 Exhaled nitric oxide output; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18301423 chr5:131593218 PDLIM4 0.38 9.57 0.35 2.32e-20 Acylcarnitine levels; BRCA cis rs2204008 0.560 rs4129033 chr12:38301897 A/T cg26384229 chr12:38710491 ALG10B -0.44 -10.03 -0.37 4.35e-22 Bladder cancer; BRCA cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.64e-23 Motion sickness; BRCA cis rs61931739 0.500 rs11053273 chr12:34547255 C/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs495337 0.736 rs686996 chr20:48476266 C/G cg17835207 chr20:48524531 SPATA2 -0.5 -11.06 -0.4 3.87e-26 Psoriasis; BRCA cis rs9790314 0.967 rs10804790 chr3:161039300 T/A cg04691961 chr3:161091175 C3orf57 -0.59 -13.97 -0.48 7.07e-39 Morning vs. evening chronotype; BRCA cis rs56104184 0.725 rs4347731 chr19:49385154 A/G cg21252483 chr19:49399788 TULP2 -0.46 -8.94 -0.33 4.3e-18 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2505998 0.957 rs1864408 chr10:43575883 T/C cg15436174 chr10:43711423 RASGEF1A -0.43 -8.43 -0.32 2.25e-16 Hirschsprung disease; BRCA cis rs1577917 0.538 rs6454483 chr6:86418283 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 12.45 0.44 5.29e-32 Response to antipsychotic treatment; BRCA cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg08917208 chr2:24149416 ATAD2B 0.93 13.86 0.48 2.21e-38 Lymphocyte counts; BRCA cis rs7246657 0.823 rs4802236 chr19:37919246 A/G cg23950597 chr19:37808831 NA -0.75 -13.12 -0.46 5.71e-35 Coronary artery calcification; BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg19346786 chr7:2764209 NA -0.33 -9.79 -0.36 3.5e-21 Height; BRCA trans rs804280 1.000 rs804280 chr8:11612698 G/T cg15556689 chr8:8085844 FLJ10661 0.33 8.93 0.33 4.4e-18 Myopia (pathological); BRCA cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg13319975 chr6:146136371 FBXO30 -0.37 -8.56 -0.32 8.47e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg01939980 chr4:1354348 KIAA1530 0.37 10.57 0.39 3.69e-24 Longevity; BRCA cis rs6831352 0.918 rs2602895 chr4:100045840 C/T cg12011299 chr4:100065546 ADH4 0.5 11.72 0.42 7.29e-29 Alcohol dependence; BRCA cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.69 -0.53 3.55e-47 Chronic sinus infection; BRCA cis rs36051895 0.623 rs3780383 chr9:5232409 G/C cg02405213 chr9:5042618 JAK2 -0.48 -8.21 -0.31 1.22e-15 Pediatric autoimmune diseases; BRCA trans rs208520 1.000 rs12209225 chr6:66996443 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.37 0.49 9.11e-41 Exhaled nitric oxide output; BRCA cis rs11718455 0.960 rs11917885 chr3:44008013 A/G cg08738300 chr3:44038990 NA -0.46 -9.06 -0.34 1.64e-18 Coronary artery disease; BRCA cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.2 0.31 1.31e-15 Mean platelet volume; BRCA cis rs6831352 0.918 rs13110176 chr4:100062430 C/T cg13256891 chr4:100009986 ADH5 0.53 9.88 0.36 1.64e-21 Alcohol dependence; BRCA cis rs9790314 0.750 rs6765270 chr3:160899974 A/G cg03342759 chr3:160939853 NMD3 -0.53 -10.91 -0.4 1.57e-25 Morning vs. evening chronotype; BRCA cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg03146154 chr1:46216737 IPP 0.45 9.84 0.36 2.28e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 19.95 0.62 3.51e-69 Platelet count; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg18402987 chr7:1209562 NA 0.82 11.85 0.42 1.95e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg23711669 chr6:146136114 FBXO30 0.79 18.86 0.6 2.06e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.932 rs6138588 chr20:25487523 C/T cg08601574 chr20:25228251 PYGB 0.35 8.4 0.32 2.92e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs28735056 0.591 rs62101204 chr18:77712832 G/A cg05491587 chr18:77659695 KCNG2 -0.32 -8.1 -0.31 2.86e-15 Schizophrenia; BRCA cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 11.18 0.4 1.28e-26 Systemic lupus erythematosus; BRCA cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg08085267 chr17:45401833 C17orf57 0.59 12.26 0.44 3.67e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7246657 0.943 rs12981532 chr19:37889280 G/A cg18154014 chr19:37997991 ZNF793 0.62 11.63 0.42 1.7e-28 Coronary artery calcification; BRCA cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs2066819 1.000 rs744051 chr12:56667298 C/T cg26734620 chr12:56694298 CS -0.91 -10.64 -0.39 1.85e-24 Psoriasis vulgaris; BRCA cis rs1568889 0.592 rs7110074 chr11:28469325 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.51 8.76 0.33 1.75e-17 Bipolar disorder; BRCA cis rs2070488 1.000 rs6772046 chr3:38479660 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 19.59 0.61 2.82e-67 Electrocardiographic conduction measures; BRCA cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg12386194 chr3:101231763 SENP7 -0.45 -9.82 -0.36 2.78e-21 Colorectal cancer; BRCA cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg26769984 chr7:1090371 C7orf50 0.68 12.78 0.45 1.76e-33 Bronchopulmonary dysplasia; BRCA cis rs700651 0.821 rs700690 chr2:198727626 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.18 0.37 1.21e-22 Intracranial aneurysm; BRCA cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg26384229 chr12:38710491 ALG10B 0.76 16.91 0.56 2.6e-53 Bladder cancer; BRCA cis rs6570726 0.935 rs407721 chr6:145871354 A/C cg23711669 chr6:146136114 FBXO30 0.64 14.85 0.51 4.51e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg12311346 chr5:56204834 C5orf35 0.61 12.73 0.45 3.11e-33 Initial pursuit acceleration; BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg21747090 chr2:27597821 SNX17 -0.39 -8.47 -0.32 1.75e-16 Total body bone mineral density; BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00149659 chr3:10157352 C3orf10 0.76 12.99 0.46 2.1e-34 Alzheimer's disease; BRCA cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg12893428 chr3:195717962 SDHAP1 0.32 7.88 0.3 1.43e-14 Pancreatic cancer; BRCA trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg21775007 chr8:11205619 TDH -0.39 -7.95 -0.3 8.33e-15 Neuroticism; BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.36 -0.41 2.22e-27 Gut microbiome composition (summer); BRCA cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg26384229 chr12:38710491 ALG10B 0.69 16.25 0.54 6.19e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs35306767 0.623 rs72760941 chr10:1141244 A/G cg20503657 chr10:835505 NA 0.67 10.55 0.39 4.26e-24 Eosinophil percentage of granulocytes; BRCA cis rs3733585 0.699 rs6852441 chr4:9973744 C/T cg11266682 chr4:10021025 SLC2A9 -0.38 -10.01 -0.37 5.17e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.84e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs965469 0.779 rs6515810 chr20:3370861 T/C cg25506879 chr20:3388711 C20orf194 -0.46 -9.05 -0.34 1.71e-18 IFN-related cytopenia; BRCA trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.03 -0.56 6.83e-54 Intelligence (multi-trait analysis); BRCA cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg16339924 chr4:17578868 LAP3 0.63 15.59 0.52 1.11e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg03676636 chr4:99064102 C4orf37 0.22 8.04 0.3 4.36e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2108225 0.900 rs4518594 chr7:107451060 G/C cg18560240 chr7:107437656 SLC26A3 -0.49 -9.86 -0.36 1.9e-21 Ulcerative colitis; BRCA trans rs11098499 0.865 rs1112817 chr4:120297800 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs867371 0.820 rs7164362 chr15:82486742 C/G cg00614314 chr15:82944287 LOC80154 0.39 7.93 0.3 1.01e-14 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs589448 0.872 rs315111 chr12:69784695 G/A cg22834771 chr12:69754056 YEATS4 -0.4 -10.02 -0.37 4.59e-22 Cerebrospinal fluid biomarker levels; BRCA cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg24531977 chr5:56204891 C5orf35 -0.78 -12.9 -0.45 5.38e-34 Type 2 diabetes; BRCA cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.45 -0.38 1.04e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg13047869 chr3:10149882 C3orf24 0.53 11.33 0.41 3.18e-27 Alzheimer's disease; BRCA cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg00531865 chr16:30841666 NA -0.38 -9.06 -0.34 1.6e-18 Dementia with Lewy bodies; BRCA cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs4268898 0.760 rs11676939 chr2:24479057 C/T cg06627628 chr2:24431161 ITSN2 0.41 8.75 0.33 1.83e-17 Asthma; BRCA cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg23583168 chr7:148888333 NA -0.99 -26.11 -0.72 8.01e-103 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11051970 0.636 rs325424 chr12:32570193 C/T cg24626660 chr12:32551988 NA 0.31 9.03 0.34 1.99e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg21926612 chr6:163149169 PACRG;PARK2 1.02 15.53 0.52 2.22e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg00701064 chr4:6280414 WFS1 -0.62 -14.81 -0.51 7.02e-43 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10044254 0.587 rs4484432 chr5:15739776 T/G cg07238450 chr5:15720153 FBXL7 -0.38 -7.9 -0.3 1.19e-14 Asthma (corticosteroid response); BRCA trans rs3780486 1.000 rs10813951 chr9:33128021 C/T cg20290983 chr6:43655470 MRPS18A -0.95 -22.17 -0.66 3.18e-81 IgG glycosylation; BRCA cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg08219700 chr8:58056026 NA 0.54 8.93 0.33 4.66e-18 Developmental language disorder (linguistic errors); BRCA cis rs4742903 0.904 rs10114234 chr9:107003646 C/T cg14250997 chr9:106856677 SMC2 -0.3 -9.45 -0.35 6.56e-20 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg23708337 chr7:1209742 NA 0.49 9.56 0.35 2.52e-20 Longevity;Endometriosis; BRCA cis rs858239 0.899 rs7794684 chr7:23310805 A/G cg23682824 chr7:23144976 KLHL7 0.36 9.09 0.34 1.24e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs6964587 1.000 rs4727267 chr7:91570290 G/C cg17063962 chr7:91808500 NA -0.53 -12.46 -0.44 4.56e-32 Breast cancer; BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg04166393 chr7:2884313 GNA12 0.52 10.0 0.37 5.74e-22 Height; BRCA cis rs2762353 0.902 rs3799344 chr6:25786993 C/T cg03517284 chr6:25882590 NA 0.39 9.04 0.34 1.8e-18 Blood metabolite levels; BRCA cis rs1401999 0.864 rs4148563 chr3:183725999 T/C cg20387954 chr3:183756860 HTR3D 0.46 10.54 0.38 4.64e-24 Anterior chamber depth; BRCA cis rs6840360 0.615 rs4696095 chr4:152467243 A/G cg22705602 chr4:152727874 NA -0.33 -8.02 -0.3 5.22e-15 Intelligence (multi-trait analysis); BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -8.13 -0.31 2.31e-15 Bipolar disorder and schizophrenia; BRCA cis rs912057 0.841 rs1294423 chr6:6743795 C/T cg06612196 chr6:6737390 NA 0.4 8.86 0.33 7.98e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs9914988 0.943 rs11656256 chr17:27153553 G/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.88 -0.33 6.75e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7582180 0.577 rs6542942 chr2:100985378 G/T cg14675211 chr2:100938903 LONRF2 0.44 9.94 0.37 9.24e-22 Intelligence (multi-trait analysis); BRCA cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg23422044 chr7:1970798 MAD1L1 0.59 10.72 0.39 9.27e-25 Bipolar disorder; BRCA trans rs11976180 1.000 rs11976037 chr7:143741024 A/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.48 -8.72 -0.33 2.47e-17 Obesity-related traits; BRCA cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg03609598 chr5:56110824 MAP3K1 -0.47 -8.24 -0.31 9.74e-16 Initial pursuit acceleration; BRCA cis rs6964587 0.967 rs34344935 chr7:91835436 G/A cg17063962 chr7:91808500 NA 0.57 13.02 0.46 1.56e-34 Breast cancer; BRCA cis rs10992471 0.603 rs11794346 chr9:95247288 C/T cg14631576 chr9:95140430 CENPP -0.38 -9.37 -0.35 1.25e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg24596788 chr1:163392923 NA -0.38 -9.9 -0.36 1.37e-21 Motion sickness; BRCA cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg26647111 chr11:31128758 NA 0.45 9.71 0.36 7.27e-21 Red blood cell count; BRCA cis rs13315871 0.929 rs11130627 chr3:58315749 G/A cg20936604 chr3:58311152 NA -0.65 -8.24 -0.31 9.48e-16 Cholesterol, total; BRCA cis rs6813479 0.523 rs2926565 chr4:137744017 C/T cg16185213 chr4:137733633 NA 0.33 7.98 0.3 6.83e-15 Longevity; BRCA cis rs11112613 0.713 rs12296355 chr12:105953321 C/A cg03607813 chr12:105948248 NA 0.55 10.4 0.38 1.6e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -15.61 -0.53 8.97e-47 Extrinsic epigenetic age acceleration; BRCA cis rs172166 0.694 rs2791332 chr6:28108788 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.98 0.3 6.85e-15 Cardiac Troponin-T levels; BRCA cis rs7927592 0.513 rs653056 chr11:68203625 T/C cg01657329 chr11:68192670 LRP5 -0.39 -9.72 -0.36 6.62e-21 Total body bone mineral density; BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.4 -0.32 2.84e-16 Total body bone mineral density; BRCA cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg08508325 chr11:3079039 CARS -0.39 -13.31 -0.47 7.71e-36 Longevity; BRCA cis rs858239 0.539 rs4294098 chr7:23185995 G/A cg23682824 chr7:23144976 KLHL7 0.41 10.63 0.39 1.99e-24 Cerebrospinal fluid biomarker levels; BRCA trans rs12517041 1.000 rs10520889 chr5:23280920 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.33 -0.31 4.92e-16 Calcium levels; BRCA trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg25214090 chr10:38739885 LOC399744 0.52 11.71 0.42 7.85e-29 Corneal astigmatism; BRCA cis rs4481887 0.830 rs10888341 chr1:248441995 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg27279351 chr12:120934652 DYNLL1 0.56 13.32 0.47 6.68e-36 High light scatter reticulocyte count; BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -12.59 -0.45 1.2e-32 Bipolar disorder and schizophrenia; BRCA cis rs6087990 0.735 rs6087420 chr20:31359391 G/A cg13636640 chr20:31349939 DNMT3B 0.67 20.46 0.63 5.89e-72 Ulcerative colitis; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg05863683 chr7:1912471 MAD1L1 0.41 8.63 0.32 4.79e-17 Bipolar disorder and schizophrenia; BRCA cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.73 -0.42 6.2e-29 Chronic sinus infection; BRCA trans rs11098499 0.954 rs878373 chr4:120237484 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.47 0.32 1.73e-16 Corneal astigmatism; BRCA cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7131987 0.868 rs7958210 chr12:29395181 G/C cg09582351 chr12:29534625 ERGIC2 -0.4 -9.6 -0.36 1.73e-20 QT interval; BRCA cis rs1003719 0.788 rs1543750 chr21:38446918 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.19 0.49 6.57e-40 Eye color traits; BRCA cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.81 -0.3 2.3e-14 Electroencephalogram traits; BRCA cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.92 0.4 1.43e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg26384229 chr12:38710491 ALG10B -0.54 -13.47 -0.47 1.4e-36 Morning vs. evening chronotype; BRCA cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg18446336 chr7:2847575 GNA12 -0.34 -8.23 -0.31 1.03e-15 Height; BRCA cis rs921968 0.565 rs12612395 chr2:219621642 G/C cg02176678 chr2:219576539 TTLL4 -0.42 -11.25 -0.41 6.19e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs9858542 0.953 rs35115732 chr3:49475155 T/C cg03060546 chr3:49711283 APEH -0.51 -10.03 -0.37 4.39e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs17209837 0.607 rs1473154 chr7:87082042 A/G cg00919237 chr7:87102261 ABCB4 -0.52 -10.19 -0.37 1.05e-22 Gallbladder cancer; BRCA cis rs1691799 0.777 rs11176145 chr12:66719795 A/G cg16791601 chr12:66731901 HELB 0.49 12.73 0.45 2.92e-33 White blood cell count (basophil); BRCA cis rs1215050 0.755 rs6843393 chr4:98822619 C/G cg05340658 chr4:99064831 C4orf37 0.45 10.19 0.37 1.12e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9325144 0.534 rs1973293 chr12:38679575 C/T cg26384229 chr12:38710491 ALG10B 0.52 13.86 0.48 2.26e-38 Morning vs. evening chronotype; BRCA cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg18252515 chr7:66147081 NA -0.65 -10.89 -0.4 1.92e-25 Diabetic kidney disease; BRCA cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg13010199 chr12:38710504 ALG10B 0.52 10.81 0.39 3.81e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs35123781 1.000 rs601336 chr5:139057167 T/C cg05227215 chr5:139057496 CXXC5 0.33 7.94 0.3 9.35e-15 Schizophrenia; BRCA cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg27170947 chr2:26402098 FAM59B 0.59 9.9 0.36 1.39e-21 Gut microbiome composition (summer); BRCA cis rs4363385 0.765 rs11205165 chr1:152986928 G/T cg24667326 chr1:152973720 SPRR3 -0.31 -8.4 -0.32 2.78e-16 Inflammatory skin disease; BRCA trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg03929089 chr4:120376271 NA 0.64 11.72 0.42 7.04e-29 Coronary artery disease; BRCA cis rs6964587 0.773 rs12536421 chr7:92008220 A/G cg01689657 chr7:91764605 CYP51A1 0.23 7.87 0.3 1.54e-14 Breast cancer; BRCA cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.67e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.92 0.4 1.39e-25 Cognitive ability; BRCA cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.96 -0.3 8.11e-15 Axial length; BRCA cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg11663144 chr21:46675770 NA -0.6 -13.87 -0.48 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg12373951 chr3:133503437 NA 0.34 8.05 0.3 3.95e-15 Iron status biomarkers; BRCA trans rs6582630 0.555 rs10880520 chr12:38464111 C/T cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.32e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg08470875 chr2:26401718 FAM59B 0.76 11.92 0.43 1.02e-29 Gut microbiome composition (summer); BRCA cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.57 0.76 9.6e-122 Cognitive ability; BRCA cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg07636037 chr3:49044803 WDR6 0.97 29.49 0.76 2.61e-121 Parkinson's disease; BRCA cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg05555928 chr11:63887634 MACROD1 -0.44 -7.99 -0.3 6.39e-15 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs4780401 0.933 rs12926451 chr16:11819569 A/C cg01061890 chr16:11836724 TXNDC11 0.36 7.89 0.3 1.35e-14 Rheumatoid arthritis; BRCA trans rs8073060 0.559 rs10438814 chr17:34007065 A/G cg19694781 chr19:47549865 TMEM160 -1.03 -21.09 -0.64 2.33e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg19920283 chr7:105172520 RINT1 0.61 9.53 0.35 3.16e-20 Bipolar disorder (body mass index interaction); BRCA cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg23422044 chr7:1970798 MAD1L1 -0.56 -9.55 -0.35 2.6e-20 Neuroticism; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg04709771 chr16:646395 RAB40C 0.45 11.25 0.41 6.33e-27 Height; BRCA cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.05 0.34 1.68e-18 Lymphocyte counts; BRCA cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg26384229 chr12:38710491 ALG10B 0.82 21.7 0.65 1.25e-78 Heart rate; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg01262667 chr19:19385393 TM6SF2 0.41 10.58 0.39 3.35e-24 Tonsillectomy; BRCA cis rs11231017 0.507 rs10897266 chr11:62155112 A/T cg23876832 chr11:62092739 NA 0.33 8.47 0.32 1.64e-16 HIV-1 viral setpoint; BRCA cis rs45509595 0.841 rs2747054 chr6:27783359 A/G cg26587870 chr6:27730563 NA -0.52 -8.02 -0.3 5.04e-15 Breast cancer; BRCA cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg00012203 chr2:219082015 ARPC2 0.49 9.76 0.36 4.64e-21 Colorectal cancer; BRCA cis rs7246657 0.943 rs1559229 chr19:37876197 T/C cg23950597 chr19:37808831 NA -0.61 -11.22 -0.41 8.27e-27 Coronary artery calcification; BRCA cis rs1371867 0.846 rs1660326 chr8:101290447 G/A cg06636551 chr8:101224915 SPAG1 -0.38 -8.58 -0.32 7.08e-17 Atrioventricular conduction; BRCA cis rs10504073 0.609 rs17644494 chr8:50019679 T/C cg00325661 chr8:49890786 NA 0.38 11.15 0.4 1.65e-26 Blood metabolite ratios; BRCA cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg18357526 chr6:26021779 HIST1H4A 0.51 9.48 0.35 4.82e-20 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.632 rs4819050 chr21:46692943 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.5 10.98 0.4 8.36e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg01262667 chr19:19385393 TM6SF2 -0.41 -10.68 -0.39 1.31e-24 Tonsillectomy; BRCA cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.85 -0.33 8.29e-18 Alzheimer's disease (late onset); BRCA cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs17384381 0.859 rs28529751 chr1:85910951 G/A cg16011679 chr1:85725395 C1orf52 0.51 7.97 0.3 7.29e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3784262 0.565 rs34676542 chr15:58318716 C/T cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.46 -0.35 5.84e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg17366294 chr4:99064904 C4orf37 0.42 9.71 0.36 6.85e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg06115741 chr20:33292138 TP53INP2 0.51 11.53 0.42 4.35e-28 Coronary artery disease; BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00802000 chr16:706648 WDR90 -0.39 -9.18 -0.34 5.86e-19 Height; BRCA cis rs6964587 0.869 rs10250014 chr7:91490208 T/C cg17063962 chr7:91808500 NA -0.54 -12.92 -0.46 4.26e-34 Breast cancer; BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs68170813 0.559 rs58663672 chr7:106949444 T/C cg02696742 chr7:106810147 HBP1 -0.53 -9.02 -0.34 2.2e-18 Coronary artery disease; BRCA cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg05340658 chr4:99064831 C4orf37 0.59 12.66 0.45 6.47e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg12011299 chr4:100065546 ADH4 0.53 12.95 0.46 3.03e-34 Alcohol dependence; BRCA cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg05283184 chr6:79620031 NA -0.42 -10.85 -0.39 2.79e-25 Intelligence (multi-trait analysis); BRCA cis rs1040555 0.516 rs242547 chr20:31418581 T/C cg13636640 chr20:31349939 DNMT3B 0.46 10.83 0.39 3.32e-25 Lymphocyte percentage of white cells; BRCA cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.21e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10267417 0.603 rs28819981 chr7:19933631 A/G cg05791153 chr7:19748676 TWISTNB 0.42 7.91 0.3 1.11e-14 Night sleep phenotypes; BRCA cis rs9814567 1.000 rs11919350 chr3:134235970 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.3 0.31 6.36e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.35 0.57 1.57e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg14863265 chr7:2801509 GNA12 -0.45 -9.48 -0.35 4.9e-20 Height; BRCA cis rs6942756 0.956 rs13235668 chr7:128879710 A/G cg02491457 chr7:128862824 NA -0.73 -14.9 -0.51 2.65e-43 White matter hyperintensity burden; BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg13628971 chr7:2884303 GNA12 0.44 8.72 0.33 2.44e-17 Height; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg18402987 chr7:1209562 NA 0.66 11.51 0.41 5.35e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg02820040 chr2:241836501 C2orf54 -0.53 -10.22 -0.37 8.42e-23 Urinary metabolites; BRCA cis rs8177253 0.632 rs6782523 chr3:133438917 C/T cg01448562 chr3:133502909 NA -0.43 -9.43 -0.35 7.36e-20 Iron status biomarkers; BRCA cis rs654950 0.806 rs941971 chr1:42040893 T/C cg06885757 chr1:42089581 HIVEP3 -0.31 -10.45 -0.38 1.03e-23 Airway imaging phenotypes; BRCA cis rs7258465 1.000 rs4808133 chr19:18608518 C/A cg01065977 chr19:18549689 ISYNA1 -0.28 -8.29 -0.31 6.59e-16 Breast cancer; BRCA cis rs6570726 0.935 rs391820 chr6:145821284 C/T cg23711669 chr6:146136114 FBXO30 0.64 15.0 0.51 8.96e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs546131 0.928 rs572690 chr11:34833614 A/G cg11058730 chr11:34937778 PDHX;APIP 0.45 8.43 0.32 2.25e-16 Lung disease severity in cystic fibrosis; BRCA cis rs6763687 0.637 rs7636026 chr3:171814021 A/T cg16233210 chr3:171778391 FNDC3B 0.4 9.38 0.35 1.16e-19 Red cell distribution width; BRCA cis rs881375 0.678 rs10739581 chr9:123696871 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.17 0.4 1.4e-26 Rheumatoid arthritis; BRCA cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg07952391 chr2:88470173 THNSL2 0.64 8.95 0.33 3.77e-18 Plasma clusterin levels; BRCA cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg12310025 chr6:25882481 NA 0.5 12.16 0.43 9.55e-31 Blood metabolite levels; BRCA cis rs6083 0.549 rs11858020 chr15:58852422 A/T cg05156742 chr15:59063176 FAM63B 0.44 9.35 0.35 1.43e-19 Schizophrenia; BRCA cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg02038168 chr22:39784481 NA 0.42 8.02 0.3 5.17e-15 Intelligence (multi-trait analysis); BRCA cis rs4566357 0.615 rs2272202 chr2:227914625 C/T cg05526886 chr2:227700861 RHBDD1 0.4 8.37 0.31 3.56e-16 Coronary artery disease; BRCA cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -12.76 -0.45 2.29e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10876993 0.928 rs10877008 chr12:58103592 A/G cg18357645 chr12:58087776 OS9 0.44 12.49 0.44 3.55e-32 Celiac disease or Rheumatoid arthritis; BRCA cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg03354898 chr7:1950403 MAD1L1 -0.6 -14.56 -0.5 1.1e-41 Bipolar disorder and schizophrenia; BRCA cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg08564027 chr20:61660810 NA -0.9 -23.39 -0.68 6.98e-88 Prostate cancer (SNP x SNP interaction); BRCA cis rs13102973 0.899 rs7442212 chr4:135899800 A/G cg14419869 chr4:135874104 NA -0.53 -10.84 -0.39 2.93e-25 Subjective well-being; BRCA cis rs2625529 0.730 rs12908882 chr15:72437572 G/A cg16672083 chr15:72433130 SENP8 -0.85 -17.86 -0.58 3.75e-58 Red blood cell count; BRCA cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.43 0.41 1.22e-27 Electroencephalogram traits; BRCA cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg05283184 chr6:79620031 NA -0.42 -10.88 -0.4 2.13e-25 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA cis rs8062405 0.964 rs7193733 chr16:28875482 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.22e-36 Developmental language disorder (linguistic errors); BRCA cis rs11098499 0.954 rs6847248 chr4:120225955 A/G cg09307838 chr4:120376055 NA 0.67 12.32 0.44 1.99e-31 Corneal astigmatism; BRCA cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.65 -0.32 4.07e-17 Monocyte percentage of white cells; BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg08470875 chr2:26401718 FAM59B 0.72 11.93 0.43 8.78e-30 Gut microbiome composition (summer); BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.89 0.33 5.97e-18 Tonsillectomy; BRCA cis rs62380364 0.602 rs665324 chr5:88055517 T/C cg22951263 chr5:87985283 NA -0.38 -10.65 -0.39 1.69e-24 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.85e-20 Tonsillectomy; BRCA cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Depression; BRCA cis rs9400271 0.632 rs34981677 chr6:109590920 T/C cg01475377 chr6:109611718 NA -0.43 -10.27 -0.38 5.06e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs672059 0.812 rs61418038 chr1:183155717 C/A ch.1.3577855R chr1:183094577 LAMC1 0.38 8.83 0.33 9.91e-18 Hypertriglyceridemia; BRCA trans rs12310956 0.532 rs6488186 chr12:33974122 G/A cg26384229 chr12:38710491 ALG10B 0.52 11.13 0.4 2.02e-26 Morning vs. evening chronotype; BRCA cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg02297831 chr4:17616191 MED28 0.36 8.24 0.31 9.75e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22590775 chr19:49891494 CCDC155 0.46 8.03 0.3 4.84e-15 Multiple sclerosis; BRCA cis rs2742234 0.614 rs3026750 chr10:43607756 G/A cg02780029 chr10:43622663 RET -0.4 -9.97 -0.37 7.55e-22 Hirschsprung disease; BRCA cis rs2073300 0.609 rs6137936 chr20:23385232 C/T cg12062639 chr20:23401060 NAPB 0.95 13.22 0.46 1.89e-35 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg23978390 chr7:1156363 C7orf50 0.41 9.33 0.35 1.73e-19 Longevity;Endometriosis; BRCA cis rs13046373 0.535 rs2832970 chr21:32020767 T/C cg14062083 chr21:31802829 KRTAP13-4 0.34 9.46 0.35 5.95e-20 HDL cholesterol; BRCA cis rs11711311 0.868 rs13091621 chr3:113481977 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.23 0.34 3.88e-19 IgG glycosylation; BRCA cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg08514558 chr10:81106712 PPIF 0.38 8.66 0.32 3.9e-17 Height; BRCA cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg23649088 chr2:200775458 C2orf69 -0.57 -8.58 -0.32 7.26e-17 Schizophrenia; BRCA cis rs61990749 0.597 rs2267768 chr14:78216014 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.57 0.39 3.61e-24 Fibroblast growth factor basic levels; BRCA cis rs4900538 0.819 rs72698591 chr14:102838896 G/A cg18135206 chr14:102964638 TECPR2 -0.96 -22.29 -0.66 7.07e-82 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -11.64 -0.42 1.58e-28 Alzheimer's disease; BRCA cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.18 0.4 1.23e-26 Bipolar disorder; BRCA cis rs1538970 0.962 rs9429077 chr1:45820667 C/A cg05343316 chr1:45956843 TESK2 0.56 11.34 0.41 2.74e-27 Platelet count; BRCA cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg06212747 chr3:49208901 KLHDC8B -0.46 -9.1 -0.34 1.1e-18 Parkinson's disease; BRCA cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg20573242 chr4:122745356 CCNA2 0.48 10.87 0.4 2.23e-25 Type 2 diabetes; BRCA cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.0 -0.37 5.53e-22 Alzheimer's disease (late onset); BRCA cis rs2882667 0.659 rs288037 chr5:138208441 A/G cg04439458 chr5:138467593 SIL1 -0.35 -8.55 -0.32 9.12e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4742903 0.967 rs10512325 chr9:106861191 C/T cg21169611 chr9:106856078 SMC2 0.35 9.25 0.34 3.19e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg26874164 chr19:58962979 ZNF324B 0.42 9.05 0.34 1.72e-18 Uric acid clearance; BRCA cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg04756594 chr16:24857601 SLC5A11 0.5 11.51 0.41 5.37e-28 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs41005 0.597 rs34452414 chr2:8101593 C/T cg03155496 chr2:8117019 LOC339788 -0.49 -11.12 -0.4 2.28e-26 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -18.97 -0.6 5.62e-64 Chronic sinus infection; BRCA cis rs11105298 0.891 rs4842653 chr12:89834113 C/T cg00757033 chr12:89920650 WDR51B 0.54 10.82 0.39 3.61e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs3008870 0.755 rs2815362 chr1:67496803 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 13.23 0.46 1.7000000000000001e-35 Lymphocyte percentage of white cells; BRCA cis rs1050631 0.564 rs1625385 chr18:33717364 C/A cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.99 -0.3 6.25e-15 Esophageal squamous cell cancer (length of survival); BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.01 -20.8 -0.64 8.85e-74 Gut microbiome composition (summer); BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg03923535 chr7:1197113 ZFAND2A 0.44 8.7 0.33 2.73e-17 Longevity;Endometriosis; BRCA cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA cis rs7267979 1.000 rs2297497 chr20:25297909 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.87 -0.36 1.79e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.77 0.33 1.65e-17 Motion sickness; BRCA cis rs507080 0.885 rs693037 chr11:118553326 C/T cg09144398 chr11:118550485 TREH -0.37 -8.9 -0.33 5.82e-18 Serum metabolite levels; BRCA cis rs11190604 1.000 rs2495737 chr10:102338344 T/C cg07080220 chr10:102295463 HIF1AN 0.56 12.4 0.44 8.77e-32 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1018836 0.923 rs12680211 chr8:91633434 C/T cg16814680 chr8:91681699 NA -0.53 -11.37 -0.41 2.04e-27 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs62158211 1.000 rs62158211 chr2:114106139 G/T cg17784749 chr2:114082611 LOC440839 0.49 8.5 0.32 1.35e-16 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; BRCA cis rs9467773 0.620 rs2504540 chr6:26641626 A/G cg09904177 chr6:26538194 HMGN4 0.46 14.64 0.5 4.66e-42 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.502 rs34972965 chr3:160984296 G/A cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Morning vs. evening chronotype; BRCA cis rs7528419 0.617 rs4970834 chr1:109814880 C/T cg00908766 chr1:109817496 CELSR2 -0.35 -8.99 -0.34 2.8e-18 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; BRCA cis rs7264396 0.832 rs224349 chr20:34045392 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.31 -0.31 5.81e-16 Total cholesterol levels; BRCA cis rs9814567 1.000 rs9989967 chr3:134238964 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.11 -0.34 1.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs61931739 0.534 rs12371021 chr12:34062252 T/C cg06521331 chr12:34319734 NA -0.62 -11.03 -0.4 5.15e-26 Morning vs. evening chronotype; BRCA trans rs6089829 1.000 rs6089828 chr20:61668998 C/T cg23505145 chr19:12996616 KLF1 0.53 12.03 0.43 3.3e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs782590 0.967 rs2627759 chr2:55853341 T/C cg18811423 chr2:55921094 PNPT1 0.73 23.54 0.68 1.07e-88 Metabolic syndrome; BRCA cis rs66887589 0.616 rs11731675 chr4:120212514 T/C cg09307838 chr4:120376055 NA 0.46 9.64 0.36 1.24e-20 Diastolic blood pressure; BRCA cis rs6087990 0.806 rs1474738 chr20:31380309 G/A cg13636640 chr20:31349939 DNMT3B 0.62 18.64 0.59 3.06e-62 Ulcerative colitis; BRCA cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg26031613 chr14:104095156 KLC1 0.7 14.77 0.5 1.15e-42 Body mass index; BRCA cis rs796364 0.865 rs769948 chr2:200728475 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.85 0.45 8.99e-34 Schizophrenia; BRCA cis rs74417235 0.684 rs12655636 chr5:154057618 T/C cg07371521 chr5:154026371 NA 0.41 8.1 0.31 2.79e-15 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg14500267 chr11:67383377 NA -0.4 -8.41 -0.32 2.73e-16 Mean corpuscular volume; BRCA cis rs58785573 0.504 rs9522 chr4:38666972 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.56 11.88 0.43 1.55e-29 Lymphocyte percentage of white cells; BRCA cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg14784868 chr12:69753453 YEATS4 -0.76 -24.83 -0.7 9.17e-96 Cerebrospinal fluid biomarker levels; BRCA cis rs10504073 0.584 rs56078938 chr8:49940342 A/C cg00325661 chr8:49890786 NA 0.51 14.6 0.5 6.96e-42 Blood metabolite ratios; BRCA cis rs7246657 0.722 rs958305 chr19:38189440 A/G cg18154014 chr19:37997991 ZNF793 -0.42 -8.05 -0.3 3.96e-15 Coronary artery calcification; BRCA cis rs2882667 0.898 rs6862393 chr5:138364698 T/C cg04439458 chr5:138467593 SIL1 -0.33 -8.93 -0.33 4.46e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12477438 0.520 rs11123765 chr2:99768064 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.52 0.77 6.7e-127 Chronic sinus infection; BRCA cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg24549020 chr5:56110836 MAP3K1 0.62 12.39 0.44 9.7e-32 Initial pursuit acceleration; BRCA cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11644478 chr21:40555479 PSMG1 0.71 13.93 0.48 1.01e-38 Cognitive function; BRCA cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.84 12.5 0.44 3.17e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.9 0.51 2.56e-43 Colorectal cancer; BRCA cis rs4713118 0.662 rs9468278 chr6:28028482 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg26647111 chr11:31128758 NA 0.45 9.79 0.36 3.41e-21 Red blood cell count; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg18538332 chr22:24372958 LOC391322 -0.49 -11.56 -0.42 3.36e-28 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -11.92 -0.43 9.74e-30 Tonsillectomy; BRCA cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg09035930 chr12:129282057 SLC15A4 0.58 17.51 0.57 2.2e-56 Systemic lupus erythematosus; BRCA cis rs3862030 0.720 rs11593971 chr10:104234090 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -13.2 -0.46 2.44e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA trans rs8002861 0.664 rs895266 chr13:44461179 T/C cg17145862 chr1:211918768 LPGAT1 0.52 11.55 0.42 3.62e-28 Leprosy; BRCA cis rs7312933 0.584 rs7974654 chr12:42630466 C/A cg01256987 chr12:42539512 GXYLT1 -0.42 -8.32 -0.31 5.3e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs11711311 1.000 rs7622403 chr3:113472434 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.45 9.81 0.36 2.89e-21 IgG glycosylation; BRCA cis rs12545109 0.765 rs2055985 chr8:57410821 T/A cg09654669 chr8:57350985 NA -0.39 -8.36 -0.31 4.02e-16 Obesity-related traits; BRCA cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.51 -0.41 5.7e-28 Electroencephalogram traits; BRCA cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.81 -0.3 2.42e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7264396 0.635 rs2425166 chr20:34439391 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.1 0.31 2.71e-15 Total cholesterol levels; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13012494 chr21:47604986 C21orf56 -0.45 -9.06 -0.34 1.6e-18 Testicular germ cell tumor; BRCA cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs2797160 0.905 rs1418641 chr6:125999854 C/T cg05901451 chr6:126070800 HEY2 -0.39 -9.41 -0.35 9.06e-20 Endometrial cancer; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg14789911 chr21:47582049 C21orf56 0.36 7.86 0.3 1.63e-14 Testicular germ cell tumor; BRCA cis rs169738 1 rs169738 chr6:33537546 A/G cg13560919 chr6:33536144 NA -0.38 -8.08 -0.3 3.32e-15 Platelet count;Autism spectrum disorder or schizophrenia; BRCA cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.78 0.36 3.76e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs400736 0.562 rs7551900 chr1:8178526 A/C cg25007680 chr1:8021821 PARK7 -0.36 -8.82 -0.33 1.05e-17 Response to antidepressants and depression; BRCA cis rs7824557 0.767 rs3808509 chr8:11163256 G/T cg21775007 chr8:11205619 TDH 0.62 12.04 0.43 3.02e-30 Retinal vascular caliber; BRCA cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.97 14.79 0.51 8.69e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9790314 0.905 rs6774276 chr3:160941318 C/T cg04691961 chr3:161091175 C3orf57 -0.59 -14.34 -0.49 1.2e-40 Morning vs. evening chronotype; BRCA cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg26373071 chr5:1325741 CLPTM1L 0.51 12.36 0.44 1.32e-31 Lung cancer; BRCA cis rs9287719 0.967 rs6712304 chr2:10754375 A/C cg00105475 chr2:10696890 NA 0.44 10.15 0.37 1.46e-22 Prostate cancer; BRCA cis rs858239 0.601 rs1034963 chr7:23148473 T/C cg23682824 chr7:23144976 KLHL7 0.45 12.17 0.43 8.16e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.83e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9503598 0.783 rs9503599 chr6:3451048 T/C cg00476032 chr6:3446245 SLC22A23 0.43 10.79 0.39 4.67e-25 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs12477438 0.765 rs6737257 chr2:99683330 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26314531 chr2:26401878 FAM59B 0.9 16.15 0.54 1.92e-49 Gut microbiome composition (summer); BRCA cis rs61931739 0.500 rs11053243 chr12:34514155 T/C cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.26e-22 Morning vs. evening chronotype; BRCA cis rs6546550 0.901 rs6546553 chr2:70111711 C/A cg02498382 chr2:70120550 SNRNP27 -0.5 -10.98 -0.4 7.86e-26 Prevalent atrial fibrillation; BRCA cis rs9527 0.668 rs7092815 chr10:104736345 G/T cg04362960 chr10:104952993 NT5C2 0.46 10.41 0.38 1.55e-23 Arsenic metabolism; BRCA cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg13902645 chr11:5959945 NA -0.53 -11.37 -0.41 2.02e-27 DNA methylation (variation); BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg22105103 chr4:187893119 NA -0.37 -11.65 -0.42 1.35e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs9287719 0.967 rs4613248 chr2:10744051 C/T cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs7772486 0.776 rs4316025 chr6:146238032 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -15.34 -0.52 1.85e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs1865721 0.656 rs724765 chr18:73139794 A/G cg26385618 chr18:73139727 C18orf62 -0.37 -9.3 -0.35 2.2e-19 Intelligence; BRCA cis rs74181299 0.750 rs12472718 chr2:65327620 G/A cg05010058 chr2:65284262 CEP68 -0.3 -8.43 -0.32 2.21e-16 Pulse pressure; BRCA cis rs6120849 0.754 rs6088667 chr20:33566722 A/C cg24642439 chr20:33292090 TP53INP2 0.57 9.91 0.37 1.21e-21 Protein C levels; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg22920501 chr2:26401640 FAM59B 0.94 16.57 0.55 1.46e-51 Gut microbiome composition (summer); BRCA trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg08975724 chr8:8085496 FLJ10661 -0.38 -7.92 -0.3 1.09e-14 Retinal vascular caliber; BRCA cis rs1971762 0.561 rs4759288 chr12:54084006 T/A cg23533419 chr12:54090519 NA -0.32 -7.97 -0.3 7.44e-15 Height; BRCA cis rs34330 0.562 rs10492235 chr12:12851339 T/G cg09462578 chr12:12878428 APOLD1 -0.68 -11.7 -0.42 8.62e-29 Systemic lupus erythematosus; BRCA cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg03060546 chr3:49711283 APEH 0.6 9.83 0.36 2.5e-21 Menarche (age at onset); BRCA cis rs1707322 0.721 rs12049027 chr1:46118184 A/T cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg20203395 chr5:56204925 C5orf35 -0.52 -10.96 -0.4 9.63e-26 Initial pursuit acceleration; BRCA cis rs6545883 0.894 rs778144 chr2:61583128 A/C cg15711740 chr2:61764176 XPO1 0.52 13.45 0.47 1.73e-36 Tuberculosis; BRCA cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg03146154 chr1:46216737 IPP 0.46 10.22 0.37 8.35e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs939658 0.805 rs4778924 chr15:79443363 T/C cg17916960 chr15:79447300 NA -0.44 -11.05 -0.4 4.3e-26 Refractive error; BRCA cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg00684032 chr4:1343700 KIAA1530 0.36 8.65 0.32 4.05e-17 Obesity-related traits; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 11.3 0.41 4.15e-27 Platelet count; BRCA trans rs7618501 0.665 rs7621352 chr3:50070763 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.47 -0.35 5.34e-20 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs2482937 chr20:25340786 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.6 -0.32 6.27e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.85 0.33 8.79e-18 Motion sickness; BRCA trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -11.01 -0.4 5.91e-26 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs9487051 0.768 rs371960 chr6:109525082 A/G cg01475377 chr6:109611718 NA -0.45 -11.51 -0.41 5.67e-28 Reticulocyte fraction of red cells; BRCA cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg21770322 chr7:97807741 LMTK2 0.44 11.72 0.42 7.34e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs17270561 0.779 rs78589800 chr6:25883500 C/G cg16482183 chr6:26056742 HIST1H1C 0.74 14.73 0.5 1.78e-42 Iron status biomarkers; BRCA cis rs208520 0.789 rs9351549 chr6:66871851 A/G cg07460842 chr6:66804631 NA -0.98 -18.46 -0.59 2.69e-61 Exhaled nitric oxide output; BRCA cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg21926612 chr6:163149169 PACRG;PARK2 1.02 15.49 0.52 3.3e-46 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9287719 0.649 rs2160258 chr2:10717221 T/A cg00105475 chr2:10696890 NA 0.41 9.23 0.34 4.02e-19 Prostate cancer; BRCA cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12826209 chr6:26865740 GUSBL1 0.58 10.45 0.38 1.03e-23 Intelligence (multi-trait analysis); BRCA cis rs4679121 0.642 rs16837507 chr3:126189395 A/G cg05485589 chr3:126194908 ZXDC -0.74 -8.36 -0.31 3.92e-16 Pursuit maintenance gain; BRCA cis rs2806561 1.000 rs1208932 chr1:23429122 T/G cg19743168 chr1:23544995 NA -0.41 -9.91 -0.37 1.21e-21 Height; BRCA cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg02196655 chr2:10830764 NOL10 -0.31 -8.27 -0.31 8.07e-16 Prostate cancer; BRCA cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg27478167 chr7:817139 HEATR2 -0.55 -11.3 -0.41 3.89e-27 Cerebrospinal P-tau181p levels; BRCA cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg26769984 chr7:1090371 C7orf50 0.65 11.47 0.41 8.13e-28 Bronchopulmonary dysplasia; BRCA cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg08213375 chr14:104286397 PPP1R13B 0.63 17.6 0.57 7.78e-57 Schizophrenia; BRCA cis rs17092148 1.000 rs1884432 chr20:33342439 A/G cg16810054 chr20:33298113 TP53INP2 -0.51 -11.45 -0.41 9.76e-28 Neuroticism; BRCA trans rs208520 0.874 rs208491 chr6:66928459 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.36 -0.54 1.72e-50 Exhaled nitric oxide output; BRCA cis rs7412746 0.611 rs10888398 chr1:150886782 A/G cg15448220 chr1:150897856 SETDB1 -0.34 -8.01 -0.3 5.42e-15 Melanoma; BRCA cis rs6815814 1.000 rs11722836 chr4:38811529 T/A cg06935464 chr4:38784597 TLR10 0.51 8.2 0.31 1.31e-15 Breast cancer; BRCA cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02018176 chr4:1364513 KIAA1530 0.4 8.17 0.31 1.67e-15 Longevity; BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg20203395 chr5:56204925 C5orf35 -0.52 -10.57 -0.39 3.58e-24 Initial pursuit acceleration; BRCA cis rs950776 0.722 rs471889 chr15:78870235 T/C cg06917634 chr15:78832804 PSMA4 -0.55 -11.98 -0.43 5.61e-30 Sudden cardiac arrest; BRCA cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg12011299 chr4:100065546 ADH4 -0.51 -11.71 -0.42 7.78e-29 Alcohol dependence; BRCA cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg13298116 chr11:62369859 EML3;MTA2 0.57 13.7 0.48 1.23e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs35110281 0.748 rs9981460 chr21:45030965 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.42 0.38 1.42e-23 Mean corpuscular volume; BRCA cis rs3771570 1.000 rs17386695 chr2:242379751 A/G cg21155796 chr2:242212141 HDLBP -0.61 -9.65 -0.36 1.18e-20 Prostate cancer; BRCA cis rs6446731 0.517 rs2157093 chr4:3270913 C/G cg08886695 chr4:3369023 RGS12 0.38 10.0 0.37 5.47e-22 Mean platelet volume; BRCA cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg24812749 chr6:127587940 RNF146 0.88 20.78 0.63 1.21e-73 Breast cancer; BRCA cis rs6901250 0.655 rs1398404 chr6:117126345 A/C cg12892004 chr6:117198278 RFX6 0.38 9.21 0.34 4.57e-19 C-reactive protein levels; BRCA cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg20203395 chr5:56204925 C5orf35 0.4 8.91 0.33 5.1e-18 Initial pursuit acceleration; BRCA cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 7.89 0.3 1.35e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg05754148 chr16:3507555 NAT15 0.39 8.15 0.31 1.86e-15 Tuberculosis; BRCA cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs1865760 0.566 rs3752419 chr6:26027433 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 11.39 0.41 1.76e-27 Height; BRCA trans rs7615952 0.641 rs61048217 chr3:125807905 G/T cg07211511 chr3:129823064 LOC729375 -0.62 -10.82 -0.39 3.47e-25 Blood pressure (smoking interaction); BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.11 -0.31 2.61e-15 Gut microbiome composition (summer); BRCA cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg22875332 chr1:76189707 ACADM 0.8 19.35 0.61 5.36e-66 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1468333 1.000 rs2906127 chr5:137539466 G/A cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.56 0.32 8.09e-17 Resting heart rate; BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg12564285 chr5:131593104 PDLIM4 0.37 9.87 0.36 1.77e-21 Breast cancer; BRCA cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg12386194 chr3:101231763 SENP7 0.39 8.45 0.32 1.98e-16 Colorectal cancer; BRCA cis rs9302635 0.513 rs8050238 chr16:72154187 C/T cg16558253 chr16:72132732 DHX38 -0.5 -10.83 -0.39 3.24e-25 Blood protein levels; BRCA cis rs11105298 0.891 rs11105325 chr12:89938590 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.51 -0.35 3.69e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4243830 0.850 rs57203351 chr1:6601319 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.91 18.16 0.58 9.24e-60 Body mass index; BRCA cis rs7178424 0.934 rs4143843 chr15:62373121 C/T cg00456672 chr15:62358751 C2CD4A -0.36 -8.26 -0.31 8.6e-16 Height; BRCA cis rs7975161 0.630 rs4964260 chr12:104634270 A/G cg25273343 chr12:104657179 TXNRD1 -0.61 -9.53 -0.35 3.31e-20 Toenail selenium levels; BRCA cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg26597838 chr10:835615 NA 1.02 18.05 0.58 3.47e-59 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg05340658 chr4:99064831 C4orf37 0.59 12.05 0.43 2.85e-30 Colonoscopy-negative controls vs population controls; BRCA trans rs2562456 0.917 rs2681377 chr19:21716520 T/C cg25042112 chr7:64838748 ZNF92 0.46 8.51 0.32 1.27e-16 Pain; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg23358479 chr7:1110784 C7orf50 -0.49 -8.2 -0.31 1.27e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg26314531 chr2:26401878 FAM59B 0.92 13.82 0.48 3.35e-38 Gut microbiome composition (summer); BRCA trans rs6461049 0.800 rs1860831 chr7:2160931 T/C cg04565464 chr8:145669602 NFKBIL2 0.44 10.39 0.38 1.79e-23 Schizophrenia; BRCA cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg05340658 chr4:99064831 C4orf37 -0.69 -17.38 -0.57 1.07e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg08859206 chr1:53392774 SCP2 0.43 8.57 0.32 8.01e-17 Monocyte count; BRCA cis rs2014572 0.967 rs4801452 chr19:57768066 A/G cg24459738 chr19:57751996 ZNF805 -0.36 -8.4 -0.32 2.85e-16 Hyperactive-impulsive symptoms; BRCA trans rs783540 0.967 rs4779044 chr15:83339353 A/C cg18393722 chr15:85113863 UBE2QP1 0.26 8.03 0.3 4.65e-15 Schizophrenia; BRCA cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg13902645 chr11:5959945 NA -0.49 -10.45 -0.38 1.08e-23 DNA methylation (variation); BRCA cis rs12618769 0.652 rs2230388 chr2:99193496 C/T cg10123293 chr2:99228465 UNC50 0.43 8.56 0.32 8.35e-17 Bipolar disorder; BRCA cis rs2839186 0.967 rs4819222 chr21:47707778 G/A cg12379764 chr21:47803548 PCNT -0.37 -7.83 -0.3 2.1e-14 Testicular germ cell tumor; BRCA trans rs75804782 0.521 rs1123472 chr2:239414355 C/T cg01134436 chr17:81009848 B3GNTL1 -0.68 -9.04 -0.34 1.92e-18 Morning vs. evening chronotype;Chronotype; BRCA cis rs12291225 0.637 rs8570 chr11:14300759 C/G cg19336497 chr11:14380999 RRAS2 -0.48 -11.98 -0.43 5.81e-30 Sense of smell; BRCA cis rs7592578 0.679 rs4287794 chr2:191327147 T/C cg11845111 chr2:191398756 TMEM194B -0.69 -13.57 -0.47 4.89e-37 Diastolic blood pressure; BRCA cis rs17092148 0.790 rs6087602 chr20:33170689 G/A cg16810054 chr20:33298113 TP53INP2 -0.47 -10.74 -0.39 7.59e-25 Neuroticism; BRCA cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg22834771 chr12:69754056 YEATS4 -0.34 -8.33 -0.31 5.11e-16 Blood protein levels; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg06085985 chr11:830527 EFCAB4A -0.41 -8.94 -0.33 4.15e-18 Mean platelet volume; BRCA cis rs4481887 0.927 rs6678798 chr1:248476617 C/T cg00666640 chr1:248458726 OR2T12 0.3 8.45 0.32 2e-16 Common traits (Other); BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.52 8.41 0.32 2.67e-16 Gut microbiome composition (summer); BRCA cis rs950776 0.752 rs2869546 chr15:78907345 C/T cg06917634 chr15:78832804 PSMA4 -0.57 -11.66 -0.42 1.23e-28 Sudden cardiac arrest; BRCA cis rs7103648 0.838 rs2293576 chr11:47434986 A/G cg03711944 chr11:47377212 SPI1 0.4 9.77 0.36 4.21e-21 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2014572 0.967 rs8111977 chr19:57759158 T/A cg24459738 chr19:57751996 ZNF805 -0.36 -8.53 -0.32 1.03e-16 Hyperactive-impulsive symptoms; BRCA cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.03 0.56 6.82e-54 Bladder cancer; BRCA cis rs6545883 0.894 rs6545867 chr2:61651027 C/T cg15711740 chr2:61764176 XPO1 0.54 13.6 0.47 3.52e-37 Tuberculosis; BRCA cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg26384229 chr12:38710491 ALG10B 0.76 16.91 0.56 2.6e-53 Bladder cancer; BRCA cis rs1348850 0.567 rs7605493 chr2:178534983 C/G cg22681709 chr2:178499509 PDE11A -0.41 -8.91 -0.33 5.31e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17741873 0.779 rs58125091 chr10:75605420 A/T cg07699608 chr10:75541558 CHCHD1 0.49 7.91 0.3 1.11e-14 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs870825 0.616 rs28649620 chr4:185648997 G/A cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs4243830 0.850 rs4908910 chr1:6599362 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -16.07 -0.54 4.79e-49 Body mass index; BRCA cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg02574844 chr11:5959923 NA 0.5 11.0 0.4 7.03e-26 DNA methylation (variation); BRCA cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2840044 1.000 rs11080357 chr17:33898933 G/A cg19694781 chr19:47549865 TMEM160 0.46 10.92 0.4 1.37e-25 Response to radiotherapy in cancer (late toxicity); BRCA cis rs12431939 0.947 rs56026555 chr14:51649066 G/T cg23942311 chr14:51606299 NA -0.44 -8.17 -0.31 1.67e-15 Cancer; BRCA cis rs6138458 1.000 rs6138458 chr20:24973769 C/T cg26195577 chr20:24973756 C20orf3 1.04 29.29 0.76 3.11e-120 Blood protein levels; BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg08280861 chr8:58055591 NA 0.6 9.42 0.35 7.86e-20 Developmental language disorder (linguistic errors); BRCA cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg27129171 chr3:47204927 SETD2 -0.71 -16.97 -0.56 1.35e-53 Colorectal cancer; BRCA cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.91 13.65 0.48 2.03e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg04450456 chr4:17643702 FAM184B 0.33 9.64 0.36 1.27e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs4596713 0.508 rs4745656 chr9:71782556 A/G cg16512924 chr15:28394682 HERC2 0.46 10.95 0.4 1.07e-25 Headache; BRCA cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.53 0.35 3.29e-20 Height; BRCA cis rs7715806 0.509 rs34349 chr5:74944868 A/G cg19683494 chr5:74908142 NA -0.66 -10.2 -0.37 9.64e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg08917208 chr2:24149416 ATAD2B 1.12 16.1 0.54 3.21e-49 Lymphocyte counts; BRCA cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.77 -0.36 4.2e-21 IgG glycosylation; BRCA trans rs11098499 0.954 rs6849171 chr4:120409549 G/A cg25214090 chr10:38739885 LOC399744 0.53 12.31 0.44 2.2e-31 Corneal astigmatism; BRCA cis rs12541635 0.677 rs62527405 chr8:107058109 G/C cg10147462 chr8:107024639 NA 0.39 10.31 0.38 3.63e-23 Age of smoking initiation; BRCA cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg02297831 chr4:17616191 MED28 0.36 8.31 0.31 5.8e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg08470875 chr2:26401718 FAM59B 0.56 8.81 0.33 1.15e-17 Gut microbiome composition (summer); BRCA cis rs12971120 0.891 rs3794953 chr18:72180519 C/T cg26446133 chr18:72167187 CNDP2 -0.73 -12.72 -0.45 3.22e-33 Refractive error; BRCA trans rs7615952 0.641 rs12491577 chr3:125731131 C/T cg07211511 chr3:129823064 LOC729375 -0.62 -10.94 -0.4 1.23e-25 Blood pressure (smoking interaction); BRCA cis rs6570726 0.516 rs10484700 chr6:145728933 C/T cg23711669 chr6:146136114 FBXO30 0.5 10.4 0.38 1.66e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs644148 1.000 rs644148 chr19:44970935 T/G cg15540054 chr19:45004280 ZNF180 -0.58 -12.16 -0.43 9.82e-31 Personality dimensions; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg15242686 chr22:24348715 GSTTP1 -0.43 -10.63 -0.39 2.06e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs8062405 0.824 rs62034319 chr16:28532188 T/G cg09719594 chr16:21412588 NA -0.34 -8.18 -0.31 1.51e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs17601876 0.520 rs28757201 chr15:51503897 G/A cg19946085 chr15:51559439 CYP19A1 -0.33 -9.02 -0.34 2.12e-18 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs10463316 0.894 rs10476769 chr5:150763970 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.4 -0.32 2.96e-16 Metabolite levels (Pyroglutamine); BRCA cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs72928364 0.929 rs62275826 chr3:100762644 G/A cg10123952 chr3:100791384 NA 0.59 8.6 0.32 6.1e-17 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.62 0.32 5.33e-17 Rheumatoid arthritis; BRCA cis rs13095912 0.889 rs35917986 chr3:185310041 G/A cg11274856 chr3:185301563 NA 0.34 8.53 0.32 1.1e-16 Systolic blood pressure; BRCA cis rs2637266 0.935 rs2583050 chr10:78403615 C/T cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 11.07 0.4 3.39e-26 Rheumatoid arthritis; BRCA cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.19 -0.43 7.39e-31 Tonsillectomy; BRCA cis rs507080 0.885 rs7926959 chr11:118559866 T/C cg09144398 chr11:118550485 TREH -0.38 -8.96 -0.33 3.57e-18 Serum metabolite levels; BRCA cis rs2777491 1.000 rs11631770 chr15:41737059 T/C cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.15 -0.54 1.95e-49 Ulcerative colitis; BRCA cis rs1580019 0.885 rs4460269 chr7:32496445 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.57 0.32 7.83e-17 Cognitive ability; BRCA cis rs12612619 0.579 rs6756245 chr2:27083489 C/T cg08802533 chr2:27073253 DPYSL5 0.29 7.91 0.3 1.14e-14 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg10011062 chr15:43941034 CATSPER2 -0.54 -7.93 -0.3 9.54e-15 Lung cancer in ever smokers; BRCA cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg05234568 chr11:5960015 NA -0.48 -9.59 -0.35 1.97e-20 DNA methylation (variation); BRCA cis rs9325144 0.671 rs12818797 chr12:39019409 A/G cg26384229 chr12:38710491 ALG10B -0.48 -11.39 -0.41 1.74e-27 Morning vs. evening chronotype; BRCA trans rs6952808 0.689 rs11771625 chr7:2050401 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 8.72 0.33 2.49e-17 Bipolar disorder and schizophrenia; BRCA cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg14784868 chr12:69753453 YEATS4 0.53 13.35 0.47 5.08e-36 Blood protein levels; BRCA cis rs12291225 0.679 rs11238 chr11:14288128 A/C cg19336497 chr11:14380999 RRAS2 0.45 11.25 0.41 6.24e-27 Sense of smell; BRCA cis rs921968 0.541 rs10200507 chr2:219335944 C/A cg02176678 chr2:219576539 TTLL4 -0.51 -12.86 -0.45 7.96e-34 Mean corpuscular hemoglobin concentration; BRCA cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg13298116 chr11:62369859 EML3;MTA2 0.58 13.56 0.47 5.14e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs877282 0.838 rs11253373 chr10:774857 A/G cg22713356 chr15:30763199 NA 1.36 26.59 0.72 1.81e-105 Uric acid levels; BRCA cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg13010199 chr12:38710504 ALG10B -0.4 -8.51 -0.32 1.21e-16 Bladder cancer; BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg21143896 chr7:2802374 GNA12 -0.34 -8.55 -0.32 9.15e-17 Height; BRCA cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg13010199 chr12:38710504 ALG10B 0.55 11.99 0.43 5.04e-30 Heart rate; BRCA cis rs921968 0.510 rs591573 chr2:219478193 C/T cg02176678 chr2:219576539 TTLL4 0.46 12.19 0.43 6.78e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs1577917 0.958 rs7739241 chr6:86575796 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.29 -0.41 4.61e-27 Response to antipsychotic treatment; BRCA cis rs67460515 0.563 rs6794882 chr3:160851849 G/A cg03342759 chr3:160939853 NMD3 -0.72 -14.94 -0.51 1.71e-43 Parkinson's disease; BRCA cis rs1448094 0.512 rs7137596 chr12:86239884 C/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.83e-19 Major depressive disorder; BRCA cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 11.65 0.42 1.35e-28 Personality dimensions; BRCA cis rs34779708 0.966 rs12761675 chr10:35438337 C/T cg03585969 chr10:35415529 CREM -0.55 -11.38 -0.41 1.84e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs8009147 1 rs8009147 chr14:104264662 A/G cg26031613 chr14:104095156 KLC1 -0.42 -8.45 -0.32 1.94e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs11148252 0.740 rs3803264 chr13:52971893 A/G cg00495681 chr13:53174319 NA -0.38 -8.12 -0.31 2.49e-15 Lewy body disease; BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.5 0.38 6.5e-24 Tonsillectomy; BRCA cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg24549020 chr5:56110836 MAP3K1 0.55 10.98 0.4 7.84e-26 Initial pursuit acceleration; BRCA cis rs11585357 1.000 rs11203346 chr1:17600822 A/G cg08277548 chr1:17600880 PADI3 -0.74 -12.93 -0.46 3.83e-34 Hair shape; BRCA cis rs7635838 0.718 rs2594981 chr3:11380638 C/G cg00170343 chr3:11313890 ATG7 0.42 8.65 0.32 4.15e-17 HDL cholesterol; BRCA cis rs700651 0.685 rs976180 chr2:198880443 C/T cg00792783 chr2:198669748 PLCL1 -0.4 -8.95 -0.33 3.73e-18 Intracranial aneurysm; BRCA cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg03433033 chr1:76189801 ACADM 0.76 17.55 0.57 1.4e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.6e-29 Bipolar disorder; BRCA cis rs17253792 0.822 rs112374071 chr14:56061919 C/T cg01858014 chr14:56050164 KTN1 -0.74 -10.1 -0.37 2.31e-22 Putamen volume; BRCA cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg13119609 chr19:45449297 APOC2 0.48 13.29 0.47 9.51e-36 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs6582630 0.502 rs4309219 chr12:38293584 A/G cg06521331 chr12:34319734 NA -0.48 -9.28 -0.34 2.57e-19 Drug-induced liver injury (flucloxacillin); BRCA trans rs9409565 0.826 rs9409564 chr9:97248166 C/T cg05679027 chr9:99775184 HIATL2 -0.42 -9.23 -0.34 3.78e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.18 0.43 7.6e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg06028605 chr16:24865363 SLC5A11 -0.46 -10.29 -0.38 4.27e-23 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg15395560 chr15:45543142 SLC28A2 -0.32 -8.64 -0.32 4.65e-17 Uric acid levels; BRCA cis rs7555523 0.887 rs4657476 chr1:165732661 A/G cg24409356 chr1:165738333 TMCO1 -0.51 -8.58 -0.32 7.08e-17 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 10.88 0.4 2.14e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg12311346 chr5:56204834 C5orf35 0.9 16.95 0.56 1.67e-53 Initial pursuit acceleration; BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg04944784 chr2:26401820 FAM59B -0.67 -11.31 -0.41 3.73e-27 Gut microbiome composition (summer); BRCA cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg27446573 chr6:127587934 RNF146 0.89 20.42 0.63 1e-71 Breast cancer; BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 16.99 0.56 1.1e-53 Platelet count; BRCA cis rs2070488 0.965 rs2126534 chr3:38445165 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.61 0.61 2.16e-67 Electrocardiographic conduction measures; BRCA cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.46 0.38 9.18e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.806 rs1589382 chr12:38408565 T/A cg06521331 chr12:34319734 NA -0.48 -8.85 -0.33 8.59e-18 Bladder cancer; BRCA cis rs992157 0.798 rs10193383 chr2:219157692 C/T cg00012203 chr2:219082015 ARPC2 0.48 9.22 0.34 4.08e-19 Colorectal cancer; BRCA cis rs7914558 0.966 rs3902934 chr10:104746649 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.44 0.38 1.2e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6598955 0.585 rs11577098 chr1:26602525 C/T cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg13877915 chr19:58951672 ZNF132 0.47 11.09 0.4 2.96e-26 Uric acid clearance; BRCA cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg08999081 chr20:33150536 PIGU 0.45 12.1 0.43 1.76e-30 Glomerular filtration rate (creatinine); BRCA cis rs9814567 0.896 rs10935123 chr3:134345327 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.38 -0.31 3.41e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg03709012 chr19:19516395 GATAD2A 0.74 16.06 0.54 5.26e-49 Tonsillectomy; BRCA cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA trans rs78049276 0.512 rs6855875 chr4:148402737 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.51 -10.53 -0.38 4.95e-24 Pulse pressure; BRCA cis rs1710278 0.935 rs1278270 chr10:127747785 G/A cg22975853 chr10:127789788 ADAM12 0.31 7.96 0.3 8.07e-15 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg08917208 chr2:24149416 ATAD2B 0.58 9.13 0.34 8.87e-19 Lymphocyte counts; BRCA cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg10523679 chr1:76189770 ACADM 0.69 11.95 0.43 7.32e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg07636037 chr3:49044803 WDR6 0.97 28.46 0.75 1.02e-115 Parkinson's disease; BRCA cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.32 -0.38 3.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4589502 0.614 rs17273637 chr15:67193084 C/T cg09911534 chr15:67153556 NA -0.69 -8.23 -0.31 1.05e-15 Lung cancer (smoking interaction); BRCA cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg26408565 chr15:76604113 ETFA -0.44 -9.56 -0.35 2.59e-20 Blood metabolite levels; BRCA cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg17971929 chr21:40555470 PSMG1 0.76 16.57 0.55 1.43e-51 Cognitive function; BRCA cis rs6460942 1.000 rs6944134 chr7:12418036 T/C cg06484146 chr7:12443880 VWDE -0.6 -8.66 -0.32 3.91e-17 Coronary artery disease; BRCA cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.01 0.4 6.14e-26 Electroencephalogram traits; BRCA cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -13.49 -0.47 1.16e-36 Chronic sinus infection; BRCA trans rs17685 0.753 rs1637051 chr7:75730659 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 27.75 0.74 7.88e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6963495 0.745 rs818620 chr7:105172685 G/C cg19920283 chr7:105172520 RINT1 0.65 12.93 0.46 3.95e-34 Bipolar disorder (body mass index interaction); BRCA cis rs826838 0.868 rs864324 chr12:39122853 A/G cg13010199 chr12:38710504 ALG10B 0.42 10.06 0.37 3.25e-22 Heart rate; BRCA cis rs12950390 0.893 rs4239165 chr17:45847272 A/T cg03474202 chr17:45855739 NA -0.45 -12.42 -0.44 7.08e-32 IgG glycosylation; BRCA cis rs867371 0.929 rs7176075 chr15:82471339 C/G cg00614314 chr15:82944287 LOC80154 0.44 9.3 0.35 2.27e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.95 0.37 8.91e-22 Bladder cancer; BRCA cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.31 -0.31 5.69e-16 Monocyte percentage of white cells; BRCA cis rs11711311 0.955 rs9813630 chr3:113377361 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.32 8.08 0.3 3.24e-15 IgG glycosylation; BRCA cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11890956 chr21:40555474 PSMG1 1.05 29.72 0.76 1.54e-122 Cognitive function; BRCA cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg23992470 chr4:843637 GAK 0.56 8.25 0.31 9e-16 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.611 rs74661620 chr2:24365260 C/A cg06627628 chr2:24431161 ITSN2 -0.53 -8.35 -0.31 4.24e-16 Lymphocyte counts; BRCA cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -14.14 -0.49 1.05e-39 Hemoglobin concentration; BRCA cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg24130564 chr14:104152367 KLC1 -0.34 -7.89 -0.3 1.33e-14 Body mass index; BRCA cis rs9287719 0.967 rs7605461 chr2:10738134 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA trans rs561341 1.000 rs497479 chr17:30328605 C/T cg27661571 chr11:113659931 NA -0.72 -11.08 -0.4 3.21e-26 Hip circumference adjusted for BMI; BRCA cis rs11679564 0.714 rs10490657 chr2:37178255 C/T cg14987922 chr2:37194071 STRN 0.4 8.42 0.32 2.45e-16 Immature fraction of reticulocytes; BRCA cis rs3806843 1.000 rs10038174 chr5:140210616 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.87 -0.36 1.72e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg11764359 chr7:65958608 NA 0.62 13.31 0.47 7.5e-36 Aortic root size; BRCA cis rs7582180 0.625 rs12612755 chr2:100906061 T/C cg14675211 chr2:100938903 LONRF2 0.38 8.34 0.31 4.63e-16 Intelligence (multi-trait analysis); BRCA trans rs7746199 0.736 rs17749927 chr6:27669976 A/G cg06606381 chr12:133084897 FBRSL1 -0.89 -8.8 -0.33 1.28e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg14019146 chr3:50243930 SLC38A3 0.42 10.09 0.37 2.48e-22 Body mass index; BRCA cis rs6733011 0.578 rs1878585 chr2:99501698 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.5 -0.32 1.31e-16 Bipolar disorder; BRCA cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg05347473 chr6:146136440 FBXO30 0.43 8.48 0.32 1.56e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg02733842 chr7:1102375 C7orf50 -0.71 -12.99 -0.46 2.07e-34 Bronchopulmonary dysplasia; BRCA trans rs61931739 0.513 rs10844698 chr12:33890158 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.44 0.35 6.6e-20 Morning vs. evening chronotype; BRCA trans rs11098499 0.863 rs13134665 chr4:120426430 T/C cg25214090 chr10:38739885 LOC399744 0.55 12.2 0.43 6.37e-31 Corneal astigmatism; BRCA cis rs559928 0.548 rs11231713 chr11:63931849 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 11.58 0.42 2.78e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs7677751 0.806 rs7698425 chr4:55090656 C/T cg17187183 chr4:55093834 PDGFRA 0.44 9.17 0.34 6.18e-19 Corneal astigmatism; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 18.52 0.59 1.25e-61 Alzheimer's disease; BRCA trans rs7615952 0.512 rs2979334 chr3:125358824 G/A cg07211511 chr3:129823064 LOC729375 -0.58 -10.71 -0.39 1.02e-24 Blood pressure (smoking interaction); BRCA cis rs3767633 0.858 rs2341468 chr1:161862312 G/A cg09175582 chr1:161736000 ATF6 0.53 8.71 0.33 2.49e-17 IgG glycosylation; BRCA trans rs12517041 1.000 rs995216 chr5:23285541 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs9914988 0.778 rs9907185 chr17:27122414 C/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs9837602 0.938 rs9823908 chr3:99795507 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.24 0.41 7.33e-27 Breast cancer; BRCA cis rs78456975 0.943 rs6721243 chr2:1580250 A/G cg01028140 chr2:1542097 TPO -0.61 -11.85 -0.42 2.04e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7809950 1.000 rs2253146 chr7:107200319 A/G cg23024343 chr7:107201750 COG5 -0.39 -8.94 -0.33 4.32e-18 Coronary artery disease; BRCA cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg07741184 chr6:167504864 NA -0.29 -8.47 -0.32 1.7e-16 Crohn's disease; BRCA cis rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05901451 chr6:126070800 HEY2 0.4 9.7 0.36 7.76e-21 Endometrial cancer; BRCA cis rs909002 0.886 rs11807225 chr1:32083193 G/C cg13919466 chr1:32135498 COL16A1 -0.27 -9.1 -0.34 1.16e-18 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.01 -0.34 2.42e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2559856 1.000 rs10745921 chr12:102087193 A/G cg12924262 chr12:102091054 CHPT1 0.38 8.56 0.32 8.5e-17 Blood protein levels; BRCA cis rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05901451 chr6:126070800 HEY2 0.39 9.58 0.35 2.2e-20 Endometrial cancer; BRCA cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg26343298 chr8:95960752 TP53INP1 0.29 8.41 0.32 2.78e-16 Type 2 diabetes; BRCA cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg08109568 chr15:31115862 NA -0.54 -13.02 -0.46 1.59e-34 Huntington's disease progression; BRCA cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg15557168 chr22:42548783 NA -0.31 -8.58 -0.32 7.07e-17 Schizophrenia; BRCA trans rs6076960 0.681 rs4487157 chr20:6249581 G/A cg17788362 chr6:86352627 SYNCRIP 0.4 7.85 0.3 1.82e-14 Smooth-surface caries; BRCA trans rs9325144 0.600 rs1825807 chr12:38737007 T/C cg23762105 chr12:34175262 ALG10 -0.41 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs6580649 0.943 rs3803183 chr12:48398080 T/A cg05342945 chr12:48394962 COL2A1 -0.47 -9.55 -0.35 2.64e-20 Lung cancer; BRCA cis rs778371 0.723 rs1973675 chr2:233636450 C/T cg08000102 chr2:233561755 GIGYF2 -0.85 -21.32 -0.64 1.37e-76 Schizophrenia; BRCA cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.93 -0.33 4.63e-18 Alzheimer's disease (late onset); BRCA cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg09184832 chr6:79620586 NA 0.51 10.83 0.39 3.33e-25 Intelligence (multi-trait analysis); BRCA cis rs7914558 0.966 rs943035 chr10:104839152 T/C cg04362960 chr10:104952993 NT5C2 0.42 10.18 0.37 1.22e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs425277 1.000 rs381664 chr1:2088104 A/G cg24578937 chr1:2090814 PRKCZ 0.58 17.92 0.58 1.69e-58 Height; BRCA cis rs10465746 0.780 rs10874423 chr1:84374071 C/T cg10977910 chr1:84465055 TTLL7 0.55 11.46 0.41 8.86e-28 Obesity-related traits; BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.06 0.34 1.53e-18 Platelet count; BRCA cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.22e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10791323 0.569 rs2282601 chr11:133712594 C/G cg14349672 chr11:133703707 NA -0.41 -9.12 -0.34 9.54e-19 Childhood ear infection; BRCA cis rs708547 0.874 rs781551 chr4:57718406 A/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.47 -10.42 -0.38 1.43e-23 Response to bleomycin (chromatid breaks); BRCA cis rs589448 0.902 rs642786 chr12:69758462 T/C cg14784868 chr12:69753453 YEATS4 0.78 24.97 0.7 1.46e-96 Cerebrospinal fluid biomarker levels; BRCA cis rs926392 0.547 rs6129161 chr20:37678327 T/G cg16355469 chr20:37678765 NA 0.51 11.58 0.42 2.72e-28 Dialysis-related mortality; BRCA cis rs67311347 1.000 rs6801859 chr3:40493218 G/T cg09455208 chr3:40491958 NA -0.43 -10.77 -0.39 5.69e-25 Renal cell carcinoma; BRCA cis rs9649465 0.935 rs1605285 chr7:123374412 A/G cg04330084 chr7:123175371 IQUB -0.31 -8.39 -0.31 3.23e-16 Migraine; BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs495337 0.735 rs636987 chr20:48524288 A/C cg17835207 chr20:48524531 SPATA2 -0.68 -16.8 -0.55 9.77e-53 Psoriasis; BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 22.34 0.66 4e-82 Platelet count; BRCA cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg11266682 chr4:10021025 SLC2A9 0.48 12.56 0.44 1.71e-32 Bone mineral density; BRCA cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg05535760 chr7:792225 HEATR2 0.83 14.24 0.49 3.57e-40 Cerebrospinal P-tau181p levels; BRCA cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.7 0.5 2.41e-42 Motion sickness; BRCA cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg21475434 chr5:93447410 FAM172A 0.65 9.0 0.34 2.59e-18 Diabetic retinopathy; BRCA cis rs73198271 0.562 rs79296712 chr8:8659978 G/A cg01851573 chr8:8652454 MFHAS1 0.49 7.94 0.3 8.88e-15 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs11690935 0.959 rs13419987 chr2:172623914 T/C cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.54 -0.77 5.19e-127 Schizophrenia; BRCA trans rs7241530 0.623 rs6506772 chr18:75918499 T/C cg25697769 chr22:39097335 JOSD1 0.38 8.26 0.31 8.47e-16 Educational attainment (years of education); BRCA cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg13010199 chr12:38710504 ALG10B -0.41 -8.71 -0.33 2.63e-17 Bladder cancer; BRCA cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg19077165 chr18:44547161 KATNAL2 -0.59 -13.49 -0.47 1.11e-36 Personality dimensions; BRCA cis rs9837602 1.000 rs7616988 chr3:99701134 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -10.68 -0.39 1.29e-24 Breast cancer; BRCA cis rs6088813 1.000 rs6142379 chr20:33999267 A/G cg14752227 chr20:34000481 UQCC -0.43 -9.15 -0.34 7.31e-19 Height; BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg20203395 chr5:56204925 C5orf35 0.52 10.69 0.39 1.14e-24 Initial pursuit acceleration; BRCA cis rs61931739 0.500 rs11052994 chr12:34065843 C/T cg06521331 chr12:34319734 NA -0.62 -11.14 -0.4 1.81e-26 Morning vs. evening chronotype; BRCA cis rs460214 0.539 rs28718905 chr21:40032244 C/A cg21578987 chr21:40029669 ERG 0.38 8.73 0.33 2.22e-17 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg01877450 chr7:97915802 BRI3 -0.37 -8.45 -0.32 2.02e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs611744 0.608 rs612744 chr8:109245991 G/A cg21045802 chr8:109455806 TTC35 0.35 7.88 0.3 1.37e-14 Dupuytren's disease; BRCA cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg26838691 chr2:24397539 C2orf84 -0.46 -8.49 -0.32 1.44e-16 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs453301 0.631 rs17700611 chr8:8793654 A/G cg15556689 chr8:8085844 FLJ10661 -0.37 -9.48 -0.35 4.7e-20 Joint mobility (Beighton score); BRCA cis rs936229 0.813 rs2168519 chr15:75080872 T/C cg10253484 chr15:75165896 SCAMP2 -0.51 -9.61 -0.36 1.68e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg14926445 chr8:58193284 C8orf71 -0.44 -8.41 -0.32 2.72e-16 Developmental language disorder (linguistic errors); BRCA cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg05868516 chr6:26286170 HIST1H4H 0.5 11.25 0.41 6.6e-27 Educational attainment; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg03354898 chr7:1950403 MAD1L1 -0.4 -8.34 -0.31 4.42e-16 Bipolar disorder and schizophrenia; BRCA cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg04553112 chr3:125709451 NA -0.55 -8.27 -0.31 7.6e-16 Blood pressure (smoking interaction); BRCA cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg25208724 chr1:156163844 SLC25A44 1.07 35.23 0.81 7.01e-152 Testicular germ cell tumor; BRCA cis rs4363385 0.818 rs2787629 chr1:153011966 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.22 -0.34 4.12e-19 Inflammatory skin disease; BRCA cis rs10197940 0.662 rs4467261 chr2:152281391 G/C cg19508488 chr2:152266495 RIF1 0.44 9.35 0.35 1.46e-19 Lung cancer; BRCA cis rs6426558 0.502 rs2813970 chr1:227410637 C/T cg10327440 chr1:227177885 CDC42BPA 0.45 8.73 0.33 2.14e-17 Neutrophil percentage of white cells; BRCA cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.61 -0.39 2.39e-24 Personality dimensions; BRCA cis rs4662945 0.603 rs10496678 chr2:130262209 C/T cg05962382 chr2:130345044 NA -0.34 -8.02 -0.3 5.05e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.36e-39 Initial pursuit acceleration; BRCA cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg22676075 chr6:135203613 NA 0.44 8.67 0.32 3.67e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1153858 1.000 rs12439274 chr15:45636667 A/G cg21132104 chr15:45694354 SPATA5L1 0.7 15.25 0.52 5.07e-45 Homoarginine levels; BRCA cis rs708547 0.874 rs1315006 chr4:57858193 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -8.8 -0.33 1.26e-17 Response to bleomycin (chromatid breaks); BRCA cis rs9467773 0.572 rs62394558 chr6:26604650 G/A cg11502198 chr6:26597334 ABT1 0.52 10.06 0.37 3.5e-22 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg26384229 chr12:38710491 ALG10B 0.69 16.16 0.54 1.62e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg18357645 chr12:58087776 OS9 -0.34 -8.36 -0.31 4.07e-16 Multiple sclerosis; BRCA trans rs35110281 0.782 rs6518302 chr21:45018478 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.52 0.38 5.4e-24 Mean corpuscular volume; BRCA cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.81 13.51 0.47 8.98e-37 Schizophrenia; BRCA cis rs11098499 0.909 rs1809406 chr4:120377122 G/A cg09307838 chr4:120376055 NA 0.76 17.1 0.56 2.9e-54 Corneal astigmatism; BRCA cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg24642439 chr20:33292090 TP53INP2 0.53 11.6 0.42 2.23e-28 Glomerular filtration rate (creatinine); BRCA cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg04546413 chr19:29218101 NA 0.64 12.28 0.44 2.81e-31 Methadone dose in opioid dependence; BRCA cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.32 0.31 5.43e-16 Axial length; BRCA trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg15556689 chr8:8085844 FLJ10661 -0.38 -9.81 -0.36 3.08e-21 Triglycerides; BRCA cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg06784218 chr1:46089804 CCDC17 0.5 12.3 0.44 2.39e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg16049864 chr8:95962084 TP53INP1 -0.49 -12.03 -0.43 3.51e-30 Type 2 diabetes; BRCA cis rs7927592 0.913 rs7123564 chr11:68362164 C/T cg20283391 chr11:68216788 NA -0.45 -8.92 -0.33 4.96e-18 Total body bone mineral density; BRCA cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg21545522 chr1:205238299 TMCC2 0.38 8.41 0.32 2.68e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs7666738 0.570 rs1921415 chr4:99093804 C/T cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 7.12e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg23018236 chr17:30244563 NA -0.63 -10.19 -0.37 1.06e-22 Hip circumference adjusted for BMI; BRCA cis rs9341808 0.628 rs2490245 chr6:80892427 A/G cg08355045 chr6:80787529 NA 0.33 8.1 0.31 2.8e-15 Sitting height ratio; BRCA cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg18876405 chr7:65276391 NA -0.51 -11.49 -0.41 6.61e-28 Aortic root size; BRCA cis rs7927771 0.542 rs6485775 chr11:47773518 A/G cg20307385 chr11:47447363 PSMC3 -0.39 -9.12 -0.34 9.9e-19 Subjective well-being; BRCA cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg17366294 chr4:99064904 C4orf37 0.45 10.78 0.39 5.29e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg18402987 chr7:1209562 NA 0.43 8.13 0.31 2.2e-15 Longevity;Endometriosis; BRCA cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg24558204 chr6:135376177 HBS1L 0.56 15.27 0.52 4.2e-45 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA trans rs11250098 0.567 rs4326350 chr8:10763655 C/G cg15556689 chr8:8085844 FLJ10661 0.32 8.31 0.31 5.78e-16 Morning vs. evening chronotype; BRCA cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg26384229 chr12:38710491 ALG10B 0.66 15.49 0.52 3.57e-46 Drug-induced liver injury (flucloxacillin); BRCA cis rs939658 0.805 rs11630571 chr15:79432992 C/A cg17916960 chr15:79447300 NA -0.44 -10.78 -0.39 5.09e-25 Refractive error; BRCA cis rs11955398 0.647 rs6449483 chr5:59995393 C/T cg02684056 chr5:59996105 DEPDC1B 0.39 8.99 0.33 2.83e-18 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg00106254 chr7:1943704 MAD1L1 -0.46 -12.31 -0.44 2.1e-31 Bipolar disorder and schizophrenia; BRCA cis rs13095912 1.000 rs17523471 chr3:185304018 T/C cg11274856 chr3:185301563 NA 0.36 8.89 0.33 6.05e-18 Systolic blood pressure; BRCA cis rs28830936 1.000 rs11632424 chr15:42095351 G/A cg17847044 chr15:42102381 MAPKBP1 -0.37 -10.06 -0.37 3.35e-22 Diastolic blood pressure; BRCA cis rs4363385 0.818 rs4845335 chr1:152993955 G/A cg25856811 chr1:152973957 SPRR3 -0.31 -8.1 -0.31 2.71e-15 Inflammatory skin disease; BRCA cis rs12348691 0.503 rs894672 chr9:100612185 C/T cg13688889 chr9:100608707 NA -0.49 -9.9 -0.36 1.35e-21 Alopecia areata; BRCA cis rs1577917 1.000 rs12207305 chr6:86723502 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.45 -0.44 5.07e-32 Response to antipsychotic treatment; BRCA cis rs7904368 0.806 rs7099178 chr10:16862578 C/G cg23933602 chr10:16859644 RSU1 0.56 8.75 0.33 1.83e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.44 0.5 4.01e-41 Personality dimensions; BRCA trans rs7824557 0.836 rs2736378 chr8:11119760 G/A cg08975724 chr8:8085496 FLJ10661 -0.44 -8.31 -0.31 5.73e-16 Retinal vascular caliber; BRCA cis rs7395581 0.918 rs4752825 chr11:47352409 G/A cg25783544 chr11:47291846 MADD 0.41 9.27 0.34 2.76e-19 HDL cholesterol; BRCA cis rs4965272 0.830 rs990422 chr15:100559768 T/C cg27344315 chr15:100560801 ADAMTS17 0.43 8.33 0.31 4.79e-16 Gastroesophageal reflux disease; BRCA cis rs826838 1.000 rs826838 chr12:39106731 C/T cg26384229 chr12:38710491 ALG10B -0.63 -16.33 -0.54 2.24e-50 Heart rate; BRCA cis rs9810890 1.000 rs73196989 chr3:128454638 G/A cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs17376456 0.877 rs10059630 chr5:93459807 C/A cg25358565 chr5:93447407 FAM172A 1.2 19.89 0.62 7.04e-69 Diabetic retinopathy; BRCA cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.95 0.4 1.12e-25 Rheumatoid arthritis; BRCA cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.41 -8.28 -0.31 7.16e-16 Rheumatoid arthritis; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.8 11.85 0.42 2.07e-29 Platelet count; BRCA cis rs61990749 0.597 rs10142722 chr14:78275549 A/T cg02301378 chr14:78227641 SNW1;C14orf178 0.61 9.55 0.35 2.66e-20 Fibroblast growth factor basic levels; BRCA cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg00012203 chr2:219082015 ARPC2 0.47 9.08 0.34 1.38e-18 Ulcerative colitis; BRCA cis rs847577 0.674 rs7790479 chr7:97713101 C/G cg21770322 chr7:97807741 LMTK2 0.55 15.72 0.53 2.69e-47 Breast cancer; BRCA cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg19901468 chr14:105411992 AHNAK2 -0.51 -12.43 -0.44 6.12e-32 Rheumatoid arthritis; BRCA cis rs7631605 0.905 rs4647269 chr3:37057591 C/T cg15934958 chr3:37212084 LRRFIP2 0.47 10.76 0.39 6.54e-25 Cerebrospinal P-tau181p levels; BRCA cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg02544614 chr20:61657117 NA 0.29 8.15 0.31 1.9e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg14349672 chr11:133703707 NA -0.41 -9.15 -0.34 7.43e-19 Childhood ear infection; BRCA cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg16099169 chr2:106886729 NA -0.59 -10.7 -0.39 1.12e-24 Facial morphology (factor 23); BRCA cis rs2832191 0.633 rs2832166 chr21:30462395 G/C cg24692254 chr21:30365293 RNF160 0.79 21.45 0.65 2.71e-77 Dental caries; BRCA cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs30380 1.000 rs30380 chr5:96122281 A/C cg16492584 chr5:96139282 ERAP1 -0.31 -7.95 -0.3 8.49e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg20891283 chr12:69753455 YEATS4 0.73 21.96 0.66 4.86e-80 Blood protein levels; BRCA cis rs7267979 0.934 rs2500399 chr20:25354694 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.42 0.52 8.02e-46 Platelet count; BRCA trans rs78049276 0.651 rs59415853 chr4:148378225 G/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.45 -8.35 -0.31 4.21e-16 Pulse pressure; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs6882046 0.513 rs187270 chr5:88026870 C/T cg22951263 chr5:87985283 NA -0.38 -10.68 -0.39 1.27e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.85 0.36 2.07e-21 Bipolar disorder; BRCA cis rs9381107 0.932 rs2223603 chr6:9487956 C/T cg14735645 chr6:9486422 NA 0.45 8.12 0.31 2.36e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs3845702 0.736 rs6733426 chr2:180830958 A/G cg01881094 chr2:180872142 CWC22 -1.0 -18.07 -0.58 2.91e-59 Schizophrenia; BRCA trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.93 0.3 1.01e-14 Corneal astigmatism; BRCA trans rs7395662 0.929 rs10838982 chr11:48640168 C/T cg00717180 chr2:96193071 NA -0.32 -8.69 -0.33 3.07e-17 HDL cholesterol; BRCA cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg21770322 chr7:97807741 LMTK2 0.42 11.28 0.41 4.79e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.05 0.54 5.96e-49 Intelligence (multi-trait analysis); BRCA cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg06115741 chr20:33292138 TP53INP2 -0.37 -8.02 -0.3 5.14e-15 Glomerular filtration rate (creatinine); BRCA cis rs8017423 0.967 rs59980414 chr14:90687738 G/C cg14092571 chr14:90743983 NA -0.34 -8.03 -0.3 4.54e-15 Mortality in heart failure; BRCA cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.22 0.58 4.99e-60 Schizophrenia; BRCA cis rs724568 0.546 rs724567 chr2:67942439 T/C cg14046302 chr2:67939758 NA -0.4 -10.22 -0.37 8.53e-23 Major depressive disorder (broad); BRCA cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg19913688 chr11:428466 ANO9 -0.67 -9.76 -0.36 4.67e-21 Body mass index; BRCA cis rs9341808 0.718 rs9448893 chr6:80837239 A/G cg08355045 chr6:80787529 NA 0.37 9.33 0.35 1.74e-19 Sitting height ratio; BRCA cis rs7092929 0.941 rs668923 chr10:3575664 G/T cg14308648 chr10:3568949 NA 0.44 8.01 0.3 5.54e-15 Coronary artery calcification; BRCA cis rs9486715 0.867 rs9386500 chr6:96889845 A/C cg06623918 chr6:96969491 KIAA0776 0.86 24.01 0.69 2.59e-91 Headache; BRCA cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg03433033 chr1:76189801 ACADM 0.67 13.55 0.47 5.82e-37 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2806561 0.765 rs623988 chr1:23519477 C/T cg12483005 chr1:23474871 LUZP1 0.44 9.81 0.36 2.88e-21 Height; BRCA cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.85 0.58 4.14e-58 Drug-induced liver injury (flucloxacillin); BRCA cis rs1003719 0.591 rs2835618 chr21:38503126 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.57 -13.21 -0.46 2.12e-35 Eye color traits; BRCA cis rs507080 0.922 rs514143 chr11:118558449 G/A cg08498647 chr11:118550644 TREH -0.37 -8.12 -0.31 2.48e-15 Serum metabolite levels; BRCA cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg17366294 chr4:99064904 C4orf37 0.42 9.87 0.36 1.78e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.57 12.14 0.43 1.14e-30 Lymphocyte counts; BRCA trans rs1493916 0.905 rs12455290 chr18:31398778 A/G cg15819921 chr19:927150 ARID3A -0.52 -9.67 -0.36 1.01e-20 Life satisfaction; BRCA cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg22467129 chr15:76604101 ETFA -0.5 -10.9 -0.4 1.7e-25 Blood metabolite levels; BRCA cis rs10754283 0.967 rs10801759 chr1:90113745 A/G cg21401794 chr1:90099060 LRRC8C 0.46 11.06 0.4 4.04e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg08917208 chr2:24149416 ATAD2B 0.57 9.07 0.34 1.43e-18 Lymphocyte counts; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg13880726 chr7:1868755 MAD1L1 0.52 9.81 0.36 2.84e-21 Bipolar disorder and schizophrenia; BRCA cis rs3809566 0.526 rs35829897 chr15:63334688 G/C cg05507819 chr15:63340323 TPM1 -0.83 -15.26 -0.52 4.77e-45 Platelet count; BRCA cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg18876405 chr7:65276391 NA 0.48 10.83 0.39 3.43e-25 Aortic root size; BRCA trans rs877282 0.898 rs11253344 chr10:765162 C/T cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg16386425 chr10:429943 DIP2C -0.4 -8.4 -0.32 2.8e-16 Psychosis in Alzheimer's disease; BRCA cis rs9875589 0.957 rs13077668 chr3:13929756 A/G cg19554555 chr3:13937349 NA -0.43 -9.13 -0.34 8.92e-19 Ovarian reserve; BRCA cis rs3768617 0.510 rs3768619 chr1:183092404 C/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.67 0.57 3.59e-57 Fuchs's corneal dystrophy; BRCA cis rs561341 0.556 rs542244 chr17:30307242 T/C cg23018236 chr17:30244563 NA -0.6 -9.9 -0.36 1.39e-21 Hip circumference adjusted for BMI; BRCA trans rs747782 0.527 rs2270993 chr11:48145166 G/A cg15704280 chr7:45808275 SEPT13 0.58 8.13 0.31 2.23e-15 Intraocular pressure; BRCA cis rs7408868 1.000 rs7247835 chr19:15262844 A/G cg14696996 chr19:15285081 NOTCH3 0.98 14.7 0.5 2.37e-42 Pulse pressure; BRCA cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg17063962 chr7:91808500 NA 0.53 12.53 0.44 2.32e-32 Breast cancer; BRCA cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.6 12.03 0.43 3.35e-30 Multiple sclerosis; BRCA cis rs1451375 0.617 rs10271341 chr7:50591583 A/C cg18232548 chr7:50535776 DDC 0.43 9.22 0.34 4.17e-19 Malaria; BRCA cis rs1506636 1.000 rs2259457 chr7:123424350 A/G cg03229431 chr7:123269106 ASB15 0.61 13.54 0.47 6.54e-37 Plateletcrit;Platelet count; BRCA trans rs6598955 0.627 rs12143920 chr1:26575834 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs9682041 0.597 rs13076319 chr3:170104630 T/G cg11886554 chr3:170076028 SKIL 0.48 9.83 0.36 2.46e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg07395648 chr5:131743802 NA -0.36 -7.99 -0.3 6.34e-15 Breast cancer; BRCA cis rs2832191 0.791 rs28633762 chr21:30500070 C/T cg08807101 chr21:30365312 RNF160 -0.59 -14.68 -0.5 3.1e-42 Dental caries; BRCA cis rs56399783 0.901 rs17241904 chr7:2875574 C/T cg19731401 chr7:2775893 GNA12 0.54 8.25 0.31 9.25e-16 Childhood ear infection; BRCA cis rs1784581 0.674 rs1789990 chr6:162406957 G/T cg17173639 chr6:162384350 PARK2 -0.33 -7.82 -0.3 2.24e-14 Itch intensity from mosquito bite; BRCA cis rs4880487 0.888 rs4880789 chr10:1254393 G/T cg03183215 chr10:1252341 ADARB2 -0.38 -8.33 -0.31 4.9e-16 Migraine; BRCA cis rs13136331 0.532 rs1462366 chr4:88570492 G/A cg22416721 chr4:88570574 DMP1 -0.6 -14.99 -0.51 9.39e-44 Sitting height ratio; BRCA cis rs6088813 1.000 rs6088821 chr20:33987576 G/A cg14752227 chr20:34000481 UQCC -0.43 -9.14 -0.34 8.09e-19 Height; BRCA cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.29 0.31 6.67e-16 Multiple sclerosis; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg22907277 chr7:1156413 C7orf50 0.52 11.51 0.41 5.37e-28 Longevity;Endometriosis; BRCA cis rs1593 0.734 rs6815076 chr4:187224558 G/C cg14349977 chr4:187219430 NA 0.57 10.37 0.38 2.1e-23 Activated partial thromboplastin time; BRCA cis rs1577917 0.958 rs6921315 chr6:86471668 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.41 -0.44 7.93e-32 Response to antipsychotic treatment; BRCA cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg06028605 chr16:24865363 SLC5A11 0.45 9.78 0.36 3.88e-21 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs3768617 0.510 rs7529465 chr1:183096880 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.5 0.57 2.46e-56 Fuchs's corneal dystrophy; BRCA trans rs17685 0.697 rs2302437 chr7:75677016 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.72 -0.74 1.21e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs965469 1.000 rs6051779 chr20:3333449 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.5 -0.38 6.58e-24 IFN-related cytopenia; BRCA cis rs11690935 0.959 rs6709156 chr2:172591944 T/C cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.48 -0.77 1.09e-126 Schizophrenia; BRCA cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs6723226 0.881 rs10181198 chr2:32686582 A/G cg02381751 chr2:32503542 YIPF4 0.64 13.76 0.48 6.15e-38 Intelligence (multi-trait analysis); BRCA cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg14036092 chr11:66035641 RAB1B 0.39 10.23 0.38 7.55e-23 Gout; BRCA cis rs9640161 0.750 rs11765644 chr7:150026339 C/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.57 -13.6 -0.47 3.5e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg21475434 chr5:93447410 FAM172A 0.65 8.28 0.31 6.96e-16 Diabetic retinopathy; BRCA cis rs2197308 0.643 rs1842597 chr12:37862142 C/G cg13010199 chr12:38710504 ALG10B -0.44 -9.5 -0.35 4.29e-20 Morning vs. evening chronotype; BRCA cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg15145296 chr3:125709740 NA -0.57 -9.39 -0.35 1.07e-19 Blood pressure (smoking interaction); BRCA trans rs6952808 0.723 rs1107592 chr7:2041432 C/T cg04565464 chr8:145669602 NFKBIL2 -0.34 -8.41 -0.32 2.61e-16 Bipolar disorder and schizophrenia; BRCA cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.31 -0.38 3.65e-23 Reticulocyte count; BRCA cis rs559928 0.606 rs76653616 chr11:63936139 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.56 0.42 3.32e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs3820928 0.845 rs13384342 chr2:227805010 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.68 -0.32 3.4e-17 Pulmonary function; BRCA cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg16179182 chr5:140090404 VTRNA1-1 0.47 10.98 0.4 8e-26 Depressive symptoms (multi-trait analysis); BRCA cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.67 -0.32 3.58e-17 Intelligence (multi-trait analysis); BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg00106254 chr7:1943704 MAD1L1 -0.32 -7.97 -0.3 7.18e-15 Bipolar disorder and schizophrenia; BRCA cis rs7727544 0.684 rs274567 chr5:131714409 C/T cg07395648 chr5:131743802 NA 0.4 10.04 0.37 4.13e-22 Blood metabolite levels; BRCA cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg11645453 chr3:52864694 ITIH4 0.48 11.63 0.42 1.73e-28 Schizophrenia; BRCA cis rs9868809 0.772 rs9812200 chr3:48695667 A/G cg00383909 chr3:49044727 WDR6 -0.43 -8.17 -0.31 1.65e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA trans rs9858542 0.953 rs9827021 chr3:49514764 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.48 -0.35 4.76e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6831352 0.918 rs17218288 chr4:100058030 A/T cg13256891 chr4:100009986 ADH5 -0.52 -9.73 -0.36 5.85e-21 Alcohol dependence; BRCA cis rs11585357 1.000 rs11585357 chr1:17601165 C/T cg19159961 chr1:17633534 PADI4 0.55 8.57 0.32 7.5e-17 Hair shape; BRCA cis rs11945232 1.000 rs11945232 chr4:88342369 A/G cg23841344 chr4:88312519 HSD17B11 -0.39 -8.2 -0.31 1.3e-15 Intelligence (multi-trait analysis); BRCA cis rs12579753 0.957 rs35001833 chr12:82188510 C/G cg07988820 chr12:82153109 PPFIA2 -0.67 -10.76 -0.39 6.11e-25 Resting heart rate; BRCA cis rs4803468 0.967 rs7259900 chr19:41889429 A/T cg09537434 chr19:41945824 ATP5SL -0.98 -23.05 -0.67 4.91e-86 Height; BRCA cis rs2425143 1.000 rs7267759 chr20:34257284 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.82 -0.33 1.07e-17 Blood protein levels; BRCA cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1371614 0.635 rs9309558 chr2:27141504 C/T cg12368169 chr2:27073192 DPYSL5 -0.3 -8.85 -0.33 8.83e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4803468 1.000 rs10417311 chr19:41902038 G/A cg09537434 chr19:41945824 ATP5SL -0.98 -23.22 -0.68 6.18e-87 Height; BRCA cis rs944722 0.839 rs8073631 chr17:26104547 C/T cg07704981 chr17:26127537 NOS2 -0.38 -8.01 -0.3 5.6e-15 Fractional exhaled nitric oxide (childhood); BRCA cis rs12348691 0.503 rs7024345 chr9:100595238 A/G cg13688889 chr9:100608707 NA -0.48 -9.85 -0.36 2.06e-21 Alopecia areata; BRCA cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg21395723 chr22:39101663 GTPBP1 0.39 8.39 0.31 3.17e-16 Menopause (age at onset); BRCA cis rs6582630 0.584 rs12832156 chr12:38419435 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.82 -0.36 2.68e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs1949733 0.701 rs940136 chr4:8448992 G/A cg11789530 chr4:8429930 ACOX3 0.59 14.57 0.5 9.58e-42 Response to antineoplastic agents; BRCA cis rs9790314 0.645 rs9879687 chr3:160874938 A/G cg03342759 chr3:160939853 NMD3 -0.61 -13.75 -0.48 6.93e-38 Morning vs. evening chronotype; BRCA cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg05623727 chr3:50126028 RBM5 0.43 10.08 0.37 2.74e-22 Intelligence (multi-trait analysis); BRCA cis rs2282802 0.651 rs6863474 chr5:139630862 C/T cg26211634 chr5:139558579 C5orf32 0.34 8.22 0.31 1.11e-15 Intelligence (multi-trait analysis); BRCA cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.47 -10.22 -0.37 7.99e-23 Multiple sclerosis; BRCA cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.63 0.53 7.54e-47 Colorectal cancer; BRCA trans rs1005277 0.579 rs1740742 chr10:38518860 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.63e-33 Extrinsic epigenetic age acceleration; BRCA cis rs312274 0.588 rs4768312 chr12:41236642 T/C cg17827154 chr12:41323612 CNTN1 0.4 9.9 0.36 1.39e-21 Metabolite levels (X-11787); BRCA cis rs62064224 0.554 rs9901737 chr17:30681354 C/G cg18200150 chr17:30822561 MYO1D 0.33 8.27 0.31 8.05e-16 Schizophrenia; BRCA trans rs7647973 0.587 rs10452032 chr3:49680973 G/A cg21659725 chr3:3221576 CRBN -0.47 -8.44 -0.32 2.17e-16 Menarche (age at onset); BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.83 -0.33 1e-17 Total body bone mineral density; BRCA cis rs9858542 0.953 rs9837027 chr3:49597013 C/T cg03060546 chr3:49711283 APEH -0.52 -10.88 -0.4 2.06e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.62 0.5 5.74e-42 Personality dimensions; BRCA cis rs4664304 0.620 rs2136977 chr2:160722850 C/T cg18514922 chr2:160761262 LY75 0.34 7.92 0.3 1.05e-14 Crohn's disease;Inflammatory bowel disease; BRCA trans rs6479891 0.818 rs59215788 chr10:65233834 A/G cg14819942 chr15:35414228 NA 0.35 8.69 0.33 3.04e-17 Arthritis (juvenile idiopathic); BRCA cis rs11190604 1.000 rs10883500 chr10:102238324 T/G cg07080220 chr10:102295463 HIF1AN 0.49 11.34 0.41 2.78e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -15.09 -0.51 3.04e-44 Initial pursuit acceleration; BRCA cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg13175981 chr1:150552382 MCL1 0.48 10.61 0.39 2.57e-24 Tonsillectomy; BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.33 -8.31 -0.31 5.77e-16 Total body bone mineral density; BRCA cis rs7602441 0.521 rs77940955 chr2:14767411 T/C cg06545361 chr2:14773388 FAM84A 0.61 8.06 0.3 3.88e-15 Visceral adipose tissue adjusted for BMI; BRCA cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg24812749 chr6:127587940 RNF146 0.66 14.91 0.51 2.21e-43 Breast cancer; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.71 15.54 0.52 1.9e-46 Lymphocyte counts; BRCA cis rs6700896 0.931 rs4655574 chr1:66135328 T/A cg04111102 chr1:66153794 NA 0.36 8.72 0.33 2.37e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg08999081 chr20:33150536 PIGU -0.46 -12.5 -0.44 3.12e-32 Glomerular filtration rate (creatinine); BRCA cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.27 8.91 0.33 5.33e-18 Bipolar disorder; BRCA cis rs8077889 0.719 rs57227660 chr17:41858984 T/C cg26893861 chr17:41843967 DUSP3 0.89 22.52 0.67 3.85e-83 Triglycerides; BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -7.98 -0.3 6.73e-15 Total body bone mineral density; BRCA cis rs875971 0.545 rs316324 chr7:65610614 A/G cg11764359 chr7:65958608 NA -0.66 -12.14 -0.43 1.21e-30 Aortic root size; BRCA cis rs7247513 0.790 rs17476839 chr19:12762783 C/T cg01871581 chr19:12707946 ZNF490 0.61 13.07 0.46 9.15e-35 Bipolar disorder; BRCA cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg13010199 chr12:38710504 ALG10B 0.54 11.77 0.42 4.49e-29 Heart rate; BRCA trans rs9951602 0.512 rs1903722 chr18:76646539 G/A cg02800362 chr5:177631904 HNRNPAB 0.77 17.94 0.58 1.43e-58 Obesity-related traits; BRCA cis rs9463078 0.845 rs1329713 chr6:45004028 A/C cg25276700 chr6:44698697 NA -0.35 -7.97 -0.3 7.38e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 15.94 0.53 2.05e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg06636001 chr8:8085503 FLJ10661 0.48 10.09 0.37 2.5e-22 Neuroticism; BRCA cis rs7584330 0.518 rs74478860 chr2:238437364 C/G cg08992911 chr2:238395768 MLPH 0.53 8.36 0.31 3.84e-16 Prostate cancer; BRCA trans rs877282 0.583 rs12356155 chr10:823940 C/T cg22713356 chr15:30763199 NA 0.95 15.33 0.52 2.01e-45 Uric acid levels; BRCA cis rs9486719 1.000 rs11152968 chr6:96908653 A/G cg06623918 chr6:96969491 KIAA0776 0.7 12.83 0.45 1.05e-33 Migraine;Coronary artery disease; BRCA cis rs868036 1.000 rs868037 chr15:68054996 A/G cg05925327 chr15:68127851 NA 0.34 8.64 0.32 4.62e-17 Restless legs syndrome; BRCA cis rs9790314 0.750 rs6765270 chr3:160899974 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -9.36 -0.35 1.29e-19 Morning vs. evening chronotype; BRCA trans rs75804782 0.566 rs56314406 chr2:239280377 A/G cg01134436 chr17:81009848 B3GNTL1 0.76 8.01 0.3 5.58e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.92 -0.3 1.08e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1003719 0.707 rs9976360 chr21:38587860 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.51 -0.5 1.83e-41 Eye color traits; BRCA cis rs17401966 0.931 rs61778401 chr1:10426474 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.28 -0.31 6.99e-16 Hepatocellular carcinoma; BRCA cis rs870825 0.550 rs28525282 chr4:185631468 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.85e-54 Blood protein levels; BRCA cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg20891283 chr12:69753455 YEATS4 0.71 20.3 0.63 4.25e-71 Blood protein levels; BRCA cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.47 8.65 0.32 4.02e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg08219700 chr8:58056026 NA -0.44 -7.98 -0.3 6.8e-15 Developmental language disorder (linguistic errors); BRCA cis rs78707713 0.592 rs3829182 chr10:71251384 A/G cg12610070 chr10:71211762 TSPAN15 -0.32 -10.13 -0.37 1.76e-22 Venous thromboembolism; BRCA cis rs12973672 1.000 rs12973672 chr19:35767866 A/G cg12095397 chr19:35769544 USF2 0.38 8.56 0.32 8.4e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg14983838 chr19:29218262 NA 0.54 10.08 0.37 2.78e-22 Methadone dose in opioid dependence; BRCA cis rs1577917 1.000 rs7771342 chr6:86631936 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA trans rs4714291 0.963 rs847743 chr6:40087154 C/G cg02267698 chr19:7991119 CTXN1 0.42 8.26 0.31 8.69e-16 Strep throat; BRCA cis rs2243480 1.000 rs36033484 chr7:65390558 T/G cg18252515 chr7:66147081 NA -0.9 -12.9 -0.45 5.33e-34 Diabetic kidney disease; BRCA cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.61 -0.32 5.69e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg22875332 chr1:76189707 ACADM 0.5 9.85 0.36 2.01e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3743102 0.591 rs78104714 chr15:83381199 C/G cg00614314 chr15:82944287 LOC80154 -0.58 -8.37 -0.31 3.66e-16 Colorectal adenoma (advanced); BRCA cis rs2011503 0.782 rs8113006 chr19:19669441 C/G cg15839431 chr19:19639596 YJEFN3 0.38 8.32 0.31 5.13e-16 Bipolar disorder; BRCA cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg24675658 chr1:53192096 ZYG11B 0.63 14.09 0.49 1.87e-39 Monocyte count; BRCA cis rs9420 0.884 rs673344 chr11:57657141 G/A cg19752551 chr11:57585705 CTNND1 0.48 12.06 0.43 2.65e-30 Schizophrenia; BRCA cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs11051970 0.879 rs950080 chr12:32588503 G/A cg02745156 chr12:32552066 NA 0.27 8.87 0.33 7.25e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg18876405 chr7:65276391 NA 0.48 10.71 0.39 1.01e-24 Aortic root size; BRCA cis rs4481887 0.962 rs4369256 chr1:248492274 G/A cg00666640 chr1:248458726 OR2T12 0.35 9.27 0.34 2.76e-19 Common traits (Other); BRCA cis rs9868809 0.772 rs13070798 chr3:48705934 C/T cg00383909 chr3:49044727 WDR6 -0.48 -9.55 -0.35 2.65e-20 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs35306767 0.623 rs72760943 chr10:1143104 G/A cg26597838 chr10:835615 NA 0.69 11.12 0.4 2.3e-26 Eosinophil percentage of granulocytes; BRCA cis rs6088813 0.857 rs6142378 chr20:33997291 T/A cg14752227 chr20:34000481 UQCC -0.43 -9.14 -0.34 8.11e-19 Height; BRCA cis rs4363385 0.679 rs6686285 chr1:152984561 T/G cg24667326 chr1:152973720 SPRR3 -0.32 -8.81 -0.33 1.22e-17 Inflammatory skin disease; BRCA cis rs4642101 0.534 rs13316229 chr3:12807371 C/T cg24848339 chr3:12840334 CAND2 0.38 9.24 0.34 3.49e-19 QRS complex (12-leadsum); BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg21747090 chr2:27597821 SNX17 -0.43 -9.47 -0.35 5.14e-20 Total body bone mineral density; BRCA cis rs7646881 0.812 rs73015665 chr3:158453934 A/T cg19483011 chr3:158453295 NA -0.46 -8.02 -0.3 4.95e-15 Tetralogy of Fallot; BRCA cis rs7267979 1.000 rs422844 chr20:25445591 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg04025307 chr7:1156635 C7orf50 0.42 7.9 0.3 1.19e-14 Bronchopulmonary dysplasia; BRCA cis rs4948102 0.595 rs10255049 chr7:56121304 G/A cg09872392 chr7:56161020 PHKG1 -0.44 -11.09 -0.4 2.95e-26 Plasma homocysteine levels (post-methionine load test); BRCA cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg19077165 chr18:44547161 KATNAL2 0.37 8.06 0.3 3.88e-15 Personality dimensions; BRCA cis rs56399783 0.901 rs73049362 chr7:2826822 G/A cg19731401 chr7:2775893 GNA12 0.52 8.44 0.32 2.17e-16 Childhood ear infection; BRCA cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg24130564 chr14:104152367 KLC1 0.34 7.81 0.3 2.35e-14 Intelligence (multi-trait analysis); BRCA trans rs1459104 0.925 rs67465952 chr11:55194045 T/A cg15704280 chr7:45808275 SEPT13 0.66 8.17 0.31 1.62e-15 Body mass index; BRCA cis rs9790314 0.967 rs336586 chr3:161081347 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.38 -0.49 7.74e-41 Morning vs. evening chronotype; BRCA cis rs11249608 0.548 rs7709054 chr5:178462757 C/T cg21905437 chr5:178450457 ZNF879 0.51 10.64 0.39 1.95e-24 Pubertal anthropometrics; BRCA cis rs754466 0.580 rs2289308 chr10:79579251 G/A cg17075019 chr10:79541650 NA -0.82 -19.74 -0.62 4.32e-68 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs812925 0.502 rs2053750 chr2:61656273 T/A cg15711740 chr2:61764176 XPO1 0.32 7.9 0.3 1.23e-14 Immature fraction of reticulocytes; BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg25036284 chr2:26402008 FAM59B -0.64 -10.71 -0.39 1e-24 Gut microbiome composition (summer); BRCA cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.52 -0.32 1.15e-16 Monocyte percentage of white cells; BRCA cis rs4766646 0.619 rs7966820 chr12:110302270 A/G cg01252219 chr12:110302105 GLTP -0.38 -8.71 -0.33 2.49e-17 Metabolite levels (MHPG); BRCA cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.08 0.4 3.27e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2882667 0.824 rs12173085 chr5:138480025 A/G cg04439458 chr5:138467593 SIL1 -0.44 -11.13 -0.4 2e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3917254 0.596 rs6754776 chr2:102764778 C/G cg22835712 chr2:102737379 NA -0.53 -8.89 -0.33 6.21e-18 Blood protein levels; BRCA trans rs11976180 1.000 rs1533266 chr7:143766714 G/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.43 -8.05 -0.3 4.02e-15 Obesity-related traits; BRCA cis rs6782228 0.606 rs2811488 chr3:128336517 C/T cg16766828 chr3:128327626 NA -0.42 -9.28 -0.34 2.57e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs17270561 0.583 rs6937800 chr6:25765943 A/G cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg17971929 chr21:40555470 PSMG1 0.61 14.16 0.49 8.34e-40 Cognitive function; BRCA cis rs9400271 0.632 rs6930698 chr6:109590304 A/G cg01475377 chr6:109611718 NA -0.43 -10.27 -0.38 5.06e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs61931739 0.500 rs11053207 chr12:34459827 A/G cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.62e-23 Morning vs. evening chronotype; BRCA cis rs2625529 0.824 rs4131630 chr15:72355398 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.45 -0.57 4.66e-56 Red blood cell count; BRCA trans rs9951602 0.512 rs9304070 chr18:76654890 A/C cg02800362 chr5:177631904 HNRNPAB 0.74 17.67 0.57 3.54e-57 Obesity-related traits; BRCA cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11890956 chr21:40555474 PSMG1 1.06 31.86 0.78 4.18e-134 Cognitive function; BRCA cis rs10751667 0.666 rs10902242 chr11:949700 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.88 0.64 3.29e-74 Chronic sinus infection; BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg21724239 chr8:58056113 NA 0.61 9.64 0.36 1.23e-20 Developmental language disorder (linguistic errors); BRCA cis rs7246760 0.867 rs8102257 chr19:9830795 C/T cg16876255 chr19:9731953 ZNF561 0.62 7.91 0.3 1.14e-14 Pursuit maintenance gain; BRCA trans rs1459104 1.000 rs12789360 chr11:55289751 C/T cg15704280 chr7:45808275 SEPT13 0.64 8.1 0.31 2.84e-15 Body mass index; BRCA trans rs453301 0.606 rs7462373 chr8:8899318 G/C cg21775007 chr8:11205619 TDH -0.4 -8.37 -0.31 3.58e-16 Joint mobility (Beighton score); BRCA cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.63 -0.61 1.65e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs250677 0.958 rs36068 chr5:148417512 C/T cg18129178 chr5:148520854 ABLIM3 -0.59 -11.98 -0.43 5.71e-30 Breast cancer; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg07092213 chr7:1199455 ZFAND2A -0.41 -8.02 -0.3 5.05e-15 Longevity;Endometriosis; BRCA cis rs77972916 0.536 rs59362315 chr2:43594931 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -10.43 -0.38 1.23e-23 Granulocyte percentage of myeloid white cells; BRCA cis rs6546550 0.658 rs10186725 chr2:70015491 A/G cg02498382 chr2:70120550 SNRNP27 -0.4 -8.55 -0.32 9.1e-17 Prevalent atrial fibrillation; BRCA trans rs931812 1.000 rs931812 chr8:101919321 A/G cg20993868 chr7:22813445 NA -0.49 -13.65 -0.48 2.13e-37 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs965469 0.947 rs965468 chr20:3381443 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.46 -0.38 9.8e-24 IFN-related cytopenia; BRCA cis rs7523050 0.730 rs72984612 chr1:109434826 T/C cg08274380 chr1:109419600 GPSM2 1.18 16.83 0.55 6.67e-53 Fat distribution (HIV); BRCA cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg26597838 chr10:835615 NA 0.91 14.21 0.49 4.98e-40 Eosinophil percentage of granulocytes; BRCA cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg17211192 chr8:82754475 SNX16 -0.49 -11.13 -0.4 1.94e-26 Diastolic blood pressure; BRCA cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg20203395 chr5:56204925 C5orf35 -0.5 -10.56 -0.39 4.06e-24 Initial pursuit acceleration; BRCA cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg16339924 chr4:17578868 LAP3 0.57 13.96 0.48 7.72e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7727544 0.684 rs272869 chr5:131677997 A/G cg24060327 chr5:131705240 SLC22A5 -0.48 -9.67 -0.36 1.02e-20 Blood metabolite levels; BRCA trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg15556689 chr8:8085844 FLJ10661 0.38 10.52 0.38 5.69e-24 Neuroticism; BRCA cis rs2762353 0.505 rs2096386 chr6:25787817 C/T cg12310025 chr6:25882481 NA 0.33 7.87 0.3 1.51e-14 Blood metabolite levels; BRCA cis rs7683537 0.725 rs28837443 chr4:185641497 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.18 0.56 1.08e-54 Systemic lupus erythematosus; BRCA cis rs7246657 0.722 rs2909105 chr19:38167906 A/G cg18154014 chr19:37997991 ZNF793 -0.5 -9.49 -0.35 4.36e-20 Coronary artery calcification; BRCA cis rs17376456 0.877 rs12374470 chr5:93481046 A/G cg21475434 chr5:93447410 FAM172A 0.68 8.69 0.33 3.1e-17 Diabetic retinopathy; BRCA cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg21951975 chr1:209979733 IRF6 0.4 9.26 0.34 2.98e-19 Cleft lip with or without cleft palate; BRCA cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.56 8.3 0.31 6.22e-16 Cerebrospinal P-tau181p levels; BRCA trans rs7746199 0.736 rs34038546 chr6:27607660 C/A cg06606381 chr12:133084897 FBRSL1 -0.86 -8.5 -0.32 1.31e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs7394190 0.630 rs78845904 chr10:75517249 C/A cg07699608 chr10:75541558 CHCHD1 0.66 9.89 0.36 1.44e-21 Incident atrial fibrillation; BRCA cis rs7524258 0.517 rs6577430 chr1:7324468 C/T cg08033730 chr1:7319125 CAMTA1 0.33 7.82 0.3 2.24e-14 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs16867321 0.639 rs12466770 chr2:181441312 C/G cg23363182 chr2:181467187 NA 0.47 10.24 0.38 6.67e-23 Obesity; BRCA cis rs12474201 0.862 rs13025595 chr2:46977893 A/G cg06386533 chr2:46925753 SOCS5 0.82 17.82 0.58 5.78e-58 Height; BRCA cis rs7607369 0.791 rs12468043 chr2:219354197 C/A cg02176678 chr2:219576539 TTLL4 0.45 11.62 0.42 1.97e-28 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg18225595 chr11:63971243 STIP1 0.56 13.54 0.47 6.93e-37 Platelet count; BRCA cis rs7944584 1.000 rs7944584 chr11:47336320 A/T cg03711944 chr11:47377212 SPI1 -0.36 -7.9 -0.3 1.24e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs812925 0.537 rs778139 chr2:61684564 A/G cg15711740 chr2:61764176 XPO1 0.32 7.82 0.3 2.13e-14 Immature fraction of reticulocytes; BRCA cis rs7903847 0.642 rs9888026 chr10:99159869 G/T cg08345082 chr10:99160200 RRP12 0.3 8.74 0.33 2.11e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg00071950 chr4:10020882 SLC2A9 0.5 11.87 0.42 1.72e-29 Bone mineral density; BRCA cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg05347473 chr6:146136440 FBXO30 0.43 8.53 0.32 1.07e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg20503657 chr10:835505 NA 0.86 15.72 0.53 2.53e-47 Eosinophil percentage of granulocytes; BRCA cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg24838063 chr12:130822603 PIWIL1 0.69 16.92 0.56 2.48e-53 Menopause (age at onset); BRCA cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg13334819 chr7:99746414 C7orf59 -0.42 -10.0 -0.37 5.87e-22 Coronary artery disease; BRCA cis rs244731 0.959 rs918459 chr5:176669030 C/T cg16006841 chr5:176797999 RGS14 -0.69 -11.26 -0.41 5.79e-27 Urate levels in lean individuals; BRCA cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg11822372 chr1:151115635 SEMA6C 0.51 8.07 0.3 3.43e-15 Blood trace element (Cu levels); BRCA cis rs12532878 0.652 rs11768465 chr7:100198386 C/T cg20848291 chr7:100343083 ZAN -0.38 -8.06 -0.3 3.87e-15 Mean corpuscular hemoglobin; BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.68 14.36 0.49 9.62e-41 Lymphocyte counts; BRCA cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg05347473 chr6:146136440 FBXO30 0.39 7.81 0.3 2.36e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.546 rs2098935 chr4:98914376 A/G cg05340658 chr4:99064831 C4orf37 0.56 11.14 0.4 1.86e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs9467711 0.591 rs34791189 chr6:26035806 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.6 9.36 0.35 1.32e-19 Autism spectrum disorder or schizophrenia; BRCA trans rs9329221 0.527 rs7833781 chr8:10333477 A/G cg06636001 chr8:8085503 FLJ10661 0.5 10.09 0.37 2.62e-22 Neuroticism; BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.55 -0.32 9.43e-17 Total body bone mineral density; BRCA cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg01181863 chr3:195395398 SDHAP2 -0.57 -10.35 -0.38 2.69e-23 Pancreatic cancer; BRCA cis rs796364 1.000 rs769950 chr2:200730028 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.85 0.45 8.99e-34 Schizophrenia; BRCA cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg26677194 chr12:130822605 PIWIL1 0.6 14.41 0.5 5.64e-41 Menopause (age at onset); BRCA cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg26647111 chr11:31128758 NA -0.44 -9.68 -0.36 9.03e-21 Red blood cell count; BRCA cis rs9341808 0.655 rs9350846 chr6:80865481 T/A cg08355045 chr6:80787529 NA 0.37 9.34 0.35 1.63e-19 Sitting height ratio; BRCA cis rs10754283 0.967 rs7523518 chr1:90110010 G/A cg21401794 chr1:90099060 LRRC8C 0.49 11.63 0.42 1.69e-28 Amyotrophic lateral sclerosis (sporadic); BRCA trans rs4650994 0.525 rs17361286 chr1:178521916 C/G cg05059571 chr16:84539110 KIAA1609 -0.58 -12.86 -0.45 7.99e-34 HDL cholesterol levels;HDL cholesterol; BRCA cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg18132916 chr6:79620363 NA -0.46 -10.43 -0.38 1.23e-23 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.63 0.55 7.2e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg23262073 chr20:60523788 NA -0.39 -8.67 -0.32 3.63e-17 Body mass index; BRCA cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg24803719 chr17:45855879 NA -0.31 -7.99 -0.3 6.54e-15 IgG glycosylation; BRCA cis rs344364 0.511 rs1742462 chr16:1946062 A/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.54 -9.6 -0.36 1.78e-20 Glomerular filtration rate in chronic kidney disease; BRCA cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg13647721 chr17:30228624 UTP6 0.56 8.05 0.3 4.16e-15 Hip circumference adjusted for BMI; BRCA cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.25 -0.38 6.05e-23 Alzheimer's disease (late onset); BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26314531 chr2:26401878 FAM59B -0.89 -16.14 -0.54 2.19e-49 Gut microbiome composition (summer); BRCA cis rs6545977 0.531 rs2539982 chr2:63111004 G/A cg17519650 chr2:63277830 OTX1 0.43 10.11 0.37 2.22e-22 Prostate cancer; BRCA cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg26769984 chr7:1090371 C7orf50 0.48 8.72 0.33 2.45e-17 Bronchopulmonary dysplasia; BRCA cis rs208515 0.518 rs12209790 chr6:66662965 T/C cg07460842 chr6:66804631 NA 0.85 15.31 0.52 2.76e-45 Exhaled nitric oxide levels; BRCA cis rs909002 0.745 rs4949458 chr1:32142332 G/T cg13919466 chr1:32135498 COL16A1 0.23 7.88 0.3 1.37e-14 Intelligence (multi-trait analysis); BRCA cis rs7560272 0.538 rs12053242 chr2:73937168 G/A cg20560298 chr2:73613845 ALMS1 0.34 8.96 0.33 3.56e-18 Schizophrenia; BRCA cis rs1215050 0.791 rs155019 chr4:98759126 G/A cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg14844989 chr11:31128820 NA -0.45 -9.62 -0.36 1.51e-20 Red blood cell count; BRCA cis rs12973672 1.000 rs10421768 chr19:35772899 A/G cg12095397 chr19:35769544 USF2 0.38 8.35 0.31 4.36e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg04727924 chr7:799746 HEATR2 -0.52 -10.14 -0.37 1.7e-22 Cerebrospinal P-tau181p levels; BRCA cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg27478167 chr7:817139 HEATR2 0.54 10.48 0.38 7.72e-24 Cerebrospinal P-tau181p levels; BRCA cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -12.27 -0.44 3.16e-31 Personality dimensions; BRCA cis rs6750047 0.605 rs1374191 chr2:38265420 T/G cg07380506 chr2:38303506 CYP1B1 -0.47 -10.26 -0.38 5.66e-23 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7408868 0.908 rs4809028 chr19:15273231 A/G cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs2859741 0.546 rs10489413 chr1:37513906 C/T cg09363841 chr1:37513479 NA -0.54 -12.49 -0.44 3.46e-32 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.41 -0.44 8.14e-32 Developmental language disorder (linguistic errors); BRCA cis rs796364 1.000 rs281763 chr2:200794870 C/T cg23649088 chr2:200775458 C2orf69 0.6 8.83 0.33 1e-17 Schizophrenia; BRCA cis rs9394841 0.667 rs3827633 chr6:41759846 A/C cg08135965 chr6:41755394 TOMM6 0.5 8.13 0.31 2.18e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs3771570 0.892 rs59715783 chr2:242366262 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.27 0.34 2.73e-19 Prostate cancer; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg27170947 chr2:26402098 FAM59B -0.96 -15.4 -0.52 9.17e-46 Gut microbiome composition (summer); BRCA trans rs12517041 1.000 rs6874000 chr5:23304235 C/T ch.8.1293020R chr8:59333349 UBXN2B 0.48 8.58 0.32 7.38e-17 Calcium levels; BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg25036284 chr2:26402008 FAM59B -0.96 -16.35 -0.54 1.76e-50 Gut microbiome composition (summer); BRCA cis rs1005277 0.502 rs2800484 chr10:38542415 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.05 -0.3 4.14e-15 Extrinsic epigenetic age acceleration; BRCA cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.03 0.37 4.23e-22 Bipolar disorder; BRCA cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.33 0.49 1.37e-40 Personality dimensions; BRCA cis rs4908768 0.539 rs1934138 chr1:8645816 G/A cg20416874 chr1:8611966 RERE -0.3 -8.35 -0.31 4.15e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.4 -7.95 -0.3 8.78e-15 Extrinsic epigenetic age acceleration; BRCA cis rs7246657 0.943 rs10422967 chr19:37850137 T/C cg18154014 chr19:37997991 ZNF793 0.61 11.48 0.41 7.17e-28 Coronary artery calcification; BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs10465746 0.967 rs5028806 chr1:84329295 G/A cg10977910 chr1:84465055 TTLL7 0.51 10.3 0.38 4.19e-23 Obesity-related traits; BRCA cis rs10046574 0.519 rs7810403 chr7:135216172 G/A cg27474649 chr7:135195673 CNOT4 0.64 10.73 0.39 7.98e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -13.19 -0.46 2.64e-35 Bipolar disorder and schizophrenia; BRCA cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg04455712 chr21:45112962 RRP1B 0.39 10.19 0.37 1.05e-22 Mean corpuscular volume; BRCA cis rs735396 0.770 rs2264782 chr12:121432603 C/T cg02403541 chr12:121454288 C12orf43 0.53 10.1 0.37 2.36e-22 N-glycan levels; BRCA cis rs7772486 0.764 rs2265471 chr6:146220250 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.98 -0.33 3e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.72e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg16339924 chr4:17578868 LAP3 0.55 12.82 0.45 1.27e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs34779708 0.966 rs12765038 chr10:35416513 G/C cg03585969 chr10:35415529 CREM 0.49 10.31 0.38 3.76e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08704250 chr15:31115839 NA -0.35 -8.77 -0.33 1.64e-17 Huntington's disease progression; BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.59 12.27 0.44 3.12e-31 Lymphocyte counts; BRCA cis rs425277 0.606 rs377283 chr1:2075570 T/C cg24578937 chr1:2090814 PRKCZ 0.38 11.53 0.41 4.59e-28 Height; BRCA cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg20203395 chr5:56204925 C5orf35 0.49 9.82 0.36 2.66e-21 Initial pursuit acceleration; BRCA cis rs10883723 1.000 rs10883723 chr10:104225832 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.04 0.56 5.91e-54 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg08564027 chr20:61660810 NA 0.84 22.5 0.66 5.42e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.565 rs2272189 chr2:219610322 G/A cg02176678 chr2:219576539 TTLL4 -0.42 -11.21 -0.41 9.84e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs600806 0.778 rs10745357 chr1:110001876 G/C cg20591472 chr1:110008990 SYPL2 0.33 8.42 0.32 2.39e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.58 0.65 5.52e-78 Gut microbiome composition (summer); BRCA trans rs12310956 0.510 rs10844693 chr12:33865197 A/G cg26384229 chr12:38710491 ALG10B -0.38 -9.0 -0.34 2.55e-18 Morning vs. evening chronotype; BRCA cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.28e-18 Motion sickness; BRCA cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.81 0.3 2.32e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4319547 0.737 rs7964138 chr12:122950375 A/G cg05707623 chr12:122985044 ZCCHC8 -0.46 -9.23 -0.34 3.84e-19 Body mass index; BRCA cis rs7264396 0.887 rs224347 chr20:34037523 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.37 -0.31 3.77e-16 Total cholesterol levels; BRCA cis rs7829975 0.617 rs4841072 chr8:8791253 C/A cg08975724 chr8:8085496 FLJ10661 -0.42 -8.9 -0.33 5.82e-18 Mood instability; BRCA cis rs61931739 0.500 rs10772160 chr12:34456848 G/A cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.63e-23 Morning vs. evening chronotype; BRCA trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg13010199 chr12:38710504 ALG10B 0.48 9.48 0.35 5.09e-20 Morning vs. evening chronotype; BRCA cis rs7605378 0.658 rs4673507 chr2:200710167 G/C cg23649088 chr2:200775458 C2orf69 0.64 13.28 0.47 1.05e-35 Osteoporosis; BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 20.1 0.62 4.94e-70 Platelet count; BRCA cis rs2742417 0.603 rs2742374 chr3:45784082 T/C cg04837898 chr3:45731254 SACM1L -0.38 -7.81 -0.3 2.31e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.48 -9.9 -0.36 1.33e-21 Tonsillectomy; BRCA cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs9790314 1.000 rs336589 chr3:161080358 C/T cg04691961 chr3:161091175 C3orf57 -0.6 -15.14 -0.51 1.7e-44 Morning vs. evening chronotype; BRCA cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg06115741 chr20:33292138 TP53INP2 0.48 10.72 0.39 8.71e-25 Coronary artery disease; BRCA cis rs2832077 0.943 rs4816332 chr21:30201706 T/C cg24692254 chr21:30365293 RNF160 -0.46 -7.96 -0.3 7.6e-15 Cognitive test performance; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07256732 chr16:621771 PIGQ -0.35 -9.12 -0.34 9.72e-19 Height; BRCA cis rs66530629 1.000 rs66530629 chr1:25032168 G/A cg01905478 chr1:25040257 NA 0.38 8.86 0.33 8.15e-18 Plateletcrit; BRCA cis rs708547 0.647 rs1718831 chr4:57886946 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.79 0.36 3.44e-21 Response to bleomycin (chromatid breaks); BRCA cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg24130564 chr14:104152367 KLC1 0.35 7.98 0.3 6.97e-15 Intelligence (multi-trait analysis); BRCA cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg11764359 chr7:65958608 NA 0.68 15.1 0.51 2.81e-44 Aortic root size; BRCA cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.46 -8.1 -0.31 2.72e-15 Body mass index (adult); BRCA trans rs75804782 0.630 rs56108200 chr2:239276888 C/T cg01134436 chr17:81009848 B3GNTL1 0.74 7.95 0.3 8.38e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg13628971 chr7:2884303 GNA12 0.46 9.25 0.34 3.2e-19 Height; BRCA cis rs8062405 1.000 rs9972693 chr16:28859802 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg06108461 chr20:60628389 TAF4 0.49 8.37 0.31 3.75e-16 Obesity-related traits; BRCA cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg00701064 chr4:6280414 WFS1 -0.71 -17.38 -0.57 1.1e-55 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs2832077 0.943 rs11700746 chr21:30189207 T/C cg14791747 chr16:20752902 THUMPD1 0.4 9.35 0.35 1.51e-19 Cognitive test performance; BRCA cis rs9807989 0.507 rs6710034 chr2:103023678 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.25e-16 Asthma; BRCA cis rs56116382 0.605 rs12715435 chr3:49338992 G/A cg00383909 chr3:49044727 WDR6 0.52 10.27 0.38 5.2e-23 Intelligence (multi-trait analysis);High light scatter reticulocyte count; BRCA cis rs7647973 0.626 rs62260723 chr3:49872124 T/C cg07636037 chr3:49044803 WDR6 -0.49 -8.27 -0.31 7.57e-16 Menarche (age at onset); BRCA cis rs67340775 0.541 rs200974 chr6:27855845 A/G cg26587870 chr6:27730563 NA -0.45 -8.03 -0.3 4.73e-15 Lung cancer in ever smokers; BRCA cis rs262150 0.851 rs2527224 chr7:158769198 G/A cg19418458 chr7:158789849 NA -0.43 -9.62 -0.36 1.52e-20 Facial morphology (factor 20); BRCA cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.67 -0.57 3.38e-57 Chronic sinus infection; BRCA cis rs1568889 1.000 rs12797689 chr11:28076042 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 13.48 0.47 1.2e-36 Bipolar disorder; BRCA trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -16.77 -0.55 1.35e-52 Intelligence (multi-trait analysis); BRCA trans rs10242455 0.557 rs77997620 chr7:99070415 G/T cg09045935 chr12:6379348 NA 0.88 8.55 0.32 9.14e-17 Blood metabolite levels; BRCA cis rs6964587 1.000 rs12537846 chr7:91721581 C/T cg17063962 chr7:91808500 NA -0.53 -12.62 -0.45 9.64e-33 Breast cancer; BRCA cis rs6700896 0.931 rs10789192 chr1:66125770 G/A cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs477692 0.629 rs945231 chr10:131294827 A/G cg05714579 chr10:131428358 MGMT 0.48 10.17 0.37 1.24e-22 Response to temozolomide; BRCA cis rs12711979 0.584 rs11694096 chr2:3868113 G/A cg17052675 chr2:3827356 NA -0.53 -15.54 -0.52 2e-46 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg14863265 chr7:2801509 GNA12 -0.5 -10.99 -0.4 7.8e-26 Height; BRCA trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21582582 chr3:182698605 DCUN1D1 0.39 10.14 0.37 1.61e-22 Intelligence (multi-trait analysis); BRCA cis rs7927592 0.913 rs7115374 chr11:68300076 G/T cg20283391 chr11:68216788 NA -0.46 -8.98 -0.33 3.03e-18 Total body bone mineral density; BRCA cis rs9682041 0.660 rs34158232 chr3:170115360 T/C cg11886554 chr3:170076028 SKIL 0.51 10.15 0.37 1.49e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg06713675 chr4:122721982 EXOSC9 -0.54 -12.37 -0.44 1.11e-31 Type 2 diabetes; BRCA cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg11764359 chr7:65958608 NA -0.64 -11.15 -0.4 1.64e-26 Aortic root size; BRCA cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.22 0.31 1.12e-15 Menopause (age at onset); BRCA cis rs7100689 0.598 rs2342815 chr10:82086532 T/C cg00277334 chr10:82204260 NA -0.43 -8.48 -0.32 1.53e-16 Post bronchodilator FEV1; BRCA cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8.32e-35 Chronic sinus infection; BRCA cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg14926445 chr8:58193284 C8orf71 -0.46 -8.69 -0.33 2.95e-17 Developmental language disorder (linguistic errors); BRCA cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg02376097 chr19:46275166 DMPK 0.43 9.7 0.36 7.64e-21 Coronary artery disease; BRCA cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.42 0.41 1.26e-27 Age-related macular degeneration (geographic atrophy); BRCA trans rs8002861 0.619 rs1337203 chr13:44423621 T/G cg12856521 chr11:46389249 DGKZ 0.37 8.13 0.31 2.15e-15 Leprosy; BRCA cis rs2370759 1.000 rs11599044 chr10:32615445 A/G cg01819863 chr10:32635814 EPC1 1.17 20.84 0.64 5.16e-74 Sexual dysfunction (female); BRCA cis rs13315871 0.929 rs71311853 chr3:58319152 C/T cg20936604 chr3:58311152 NA -0.66 -8.42 -0.32 2.54e-16 Cholesterol, total; BRCA cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg01874867 chr7:94954059 PON1 -0.4 -8.26 -0.31 8.66e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg18404041 chr3:52824283 ITIH1 -0.37 -11.21 -0.41 9.26e-27 Electroencephalogram traits; BRCA cis rs4481887 0.861 rs6681336 chr1:248482756 C/T cg00666640 chr1:248458726 OR2T12 0.31 8.73 0.33 2.19e-17 Common traits (Other); BRCA trans rs6582630 0.555 rs4601853 chr12:38435569 G/A cg06521331 chr12:34319734 NA -0.46 -8.53 -0.32 1.08e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.73 10.2 0.37 9.6e-23 Initial pursuit acceleration; BRCA cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14442939 chr10:27389572 ANKRD26 0.64 10.74 0.39 7.61e-25 Breast cancer; BRCA cis rs9837602 1.000 rs6806178 chr3:99780393 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.56 0.39 3.77e-24 Breast cancer; BRCA cis rs7727544 0.684 rs2516788 chr5:131715565 G/C cg07395648 chr5:131743802 NA 0.4 9.96 0.37 7.84e-22 Blood metabolite levels; BRCA cis rs6430585 0.583 rs111837148 chr2:136612036 G/A cg07169764 chr2:136633963 MCM6 1.28 28.75 0.75 2.6e-117 Corneal structure; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg16606324 chr3:10149918 C3orf24 0.57 11.38 0.41 1.87e-27 Alzheimer's disease; BRCA cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg02503808 chr4:7069936 GRPEL1 -0.79 -14.52 -0.5 1.79e-41 Monocyte percentage of white cells; BRCA cis rs8062405 1.000 rs2008514 chr16:28825605 A/G cg16576597 chr16:28551801 NUPR1 -0.29 -8.05 -0.3 3.95e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6860806 0.531 rs274556 chr5:131722075 A/G cg07395648 chr5:131743802 NA 0.37 8.02 0.3 4.93e-15 Breast cancer; BRCA cis rs4243830 1.000 rs58415361 chr1:6592377 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.92 13.91 0.48 1.3e-38 Body mass index; BRCA cis rs4363385 0.747 rs6668696 chr1:152964910 A/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.52 -0.32 1.18e-16 Inflammatory skin disease; BRCA cis rs1555322 0.530 rs7004 chr20:33866753 G/C cg17927777 chr20:33865990 NA 0.47 8.71 0.33 2.67e-17 Attention deficit hyperactivity disorder; BRCA cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.08 0.4 3.31e-26 Bipolar disorder; BRCA cis rs801193 0.660 rs2659897 chr7:66187715 A/G cg18876405 chr7:65276391 NA -0.51 -12.02 -0.43 3.98e-30 Aortic root size; BRCA cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg16339924 chr4:17578868 LAP3 0.63 15.85 0.53 5.85e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2637266 0.905 rs2579772 chr10:78406555 A/G cg18941641 chr10:78392320 NA 0.36 8.3 0.31 6.03e-16 Pulmonary function; BRCA cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg20848291 chr7:100343083 ZAN -0.6 -12.59 -0.45 1.23e-32 Other erythrocyte phenotypes; BRCA trans rs208520 0.690 rs12197578 chr6:66725905 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 20.36 0.63 1.98e-71 Exhaled nitric oxide output; BRCA cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg09184832 chr6:79620586 NA -0.44 -8.52 -0.32 1.12e-16 Intelligence (multi-trait analysis); BRCA cis rs9612 1.000 rs28373139 chr19:44246706 A/G cg08581076 chr19:44259116 C19orf61 0.52 9.02 0.34 2.17e-18 Exhaled nitric oxide output; BRCA cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg21427119 chr20:30132790 HM13 -0.44 -9.29 -0.35 2.34e-19 Mean corpuscular hemoglobin; BRCA cis rs7914558 0.966 rs10748839 chr10:104953547 A/G cg04362960 chr10:104952993 NT5C2 0.41 9.73 0.36 5.65e-21 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9487051 0.703 rs351755 chr6:109538073 G/A cg21918786 chr6:109611834 NA 0.36 9.6 0.35 1.81e-20 Reticulocyte fraction of red cells; BRCA cis rs16866061 1.000 rs72974238 chr2:225432470 C/A cg12698349 chr2:225449008 CUL3 0.79 20.49 0.63 4.1e-72 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7917772 0.582 rs10786689 chr10:104356359 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg04944784 chr2:26401820 FAM59B -0.74 -11.85 -0.42 2.1e-29 Gut microbiome composition (summer); BRCA cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg06028605 chr16:24865363 SLC5A11 0.45 9.74 0.36 5.58e-21 Intelligence (multi-trait analysis); BRCA cis rs17601876 0.814 rs34784350 chr15:51559552 C/T cg19946085 chr15:51559439 CYP19A1 -0.36 -10.19 -0.37 1.08e-22 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA trans rs208520 1.000 rs12192261 chr6:66985268 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.46 0.5 3.3e-41 Exhaled nitric oxide output; BRCA cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.1 0.31 2.7e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg12923728 chr3:195709715 SDHAP1 -0.58 -12.58 -0.45 1.45e-32 Pancreatic cancer; BRCA cis rs637571 0.522 rs538954 chr11:65756808 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.7 0.36 7.73e-21 Eosinophil percentage of white cells; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.2 0.56 9.34e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -8.96 -0.33 3.67e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA trans rs2204008 0.616 rs1607852 chr12:38398125 G/A cg06521331 chr12:34319734 NA -0.51 -9.15 -0.34 7.41e-19 Bladder cancer; BRCA cis rs835154 0.817 rs835157 chr5:14874533 T/C cg18064842 chr5:14874549 NA -0.51 -13.61 -0.47 3.01e-37 Blood metabolite levels; BRCA cis rs9818758 0.607 rs9862483 chr3:49195441 G/A cg01304814 chr3:48885189 PRKAR2A 0.63 7.84 0.3 1.91e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg13010199 chr12:38710504 ALG10B 0.54 11.48 0.41 7.08e-28 Heart rate; BRCA cis rs3733585 0.699 rs17245723 chr4:9962218 A/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.45 -0.38 1.04e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs11039798 0.557 rs683180 chr11:48463949 A/G cg15704280 chr7:45808275 SEPT13 -0.46 -7.94 -0.3 9.25e-15 Axial length; BRCA cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg20503657 chr10:835505 NA 1.33 22.05 0.66 1.42e-80 Eosinophil percentage of granulocytes; BRCA cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.7 14.26 0.49 2.95e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs977987 0.843 rs11860231 chr16:75385159 A/G cg03315344 chr16:75512273 CHST6 0.52 12.04 0.43 2.97e-30 Dupuytren's disease; BRCA cis rs11758351 0.925 rs78932312 chr6:26194869 A/G cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg10932868 chr11:921992 NA 0.5 13.0 0.46 1.88e-34 Alzheimer's disease (late onset); BRCA cis rs10896135 0.526 rs12795774 chr11:66381517 T/C cg24851651 chr11:66362959 CCS -0.45 -9.08 -0.34 1.37e-18 Bipolar disorder; BRCA trans rs11039798 0.588 rs7479642 chr11:48553808 G/T cg03929089 chr4:120376271 NA 0.49 8.17 0.31 1.7e-15 Axial length; BRCA cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg12935359 chr14:103987150 CKB -0.6 -13.61 -0.47 3.28e-37 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.39 -0.38 1.72e-23 Initial pursuit acceleration; BRCA cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg06640241 chr16:89574553 SPG7 0.77 18.48 0.59 2.18e-61 Multiple myeloma (IgH translocation); BRCA cis rs2235642 0.785 rs1057983 chr16:1660274 A/G cg26528668 chr16:1614120 IFT140 0.34 7.93 0.3 9.75e-15 Coronary artery disease; BRCA cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg24110177 chr3:50126178 RBM5 -0.51 -14.48 -0.5 2.58e-41 Body mass index; BRCA cis rs507080 0.883 rs563549 chr11:118558953 G/A cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA cis rs3806843 0.868 rs2531349 chr5:140120953 G/A cg16179182 chr5:140090404 VTRNA1-1 0.42 9.8 0.36 3.12e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs6582630 0.555 rs7133706 chr12:38475465 G/A cg06521331 chr12:34319734 NA 0.45 8.78 0.33 1.47e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7100689 0.577 rs9421464 chr10:82043426 C/T cg01528321 chr10:82214614 TSPAN14 0.77 17.31 0.57 2.34e-55 Post bronchodilator FEV1; BRCA cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg04414720 chr1:150670196 GOLPH3L 0.35 7.83 0.3 2.05e-14 Tonsillectomy; BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -11.54 -0.42 4.21e-28 Tonsillectomy; BRCA cis rs72781680 0.948 rs72790326 chr2:24126153 C/T cg20701182 chr2:24300061 SF3B14 0.57 9.01 0.34 2.39e-18 Lymphocyte counts; BRCA cis rs9296092 0.538 rs62405941 chr6:33517297 G/A cg13560919 chr6:33536144 NA -0.85 -17.41 -0.57 7.54e-56 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg08470875 chr2:26401718 FAM59B -0.63 -9.49 -0.35 4.62e-20 Gut microbiome composition (summer); BRCA cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg16950941 chr11:66035639 RAB1B 0.44 11.97 0.43 6.29e-30 Gout; BRCA cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -8.18 -0.31 1.57e-15 Longevity;Endometriosis; BRCA cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg03517284 chr6:25882590 NA 0.7 15.67 0.53 4.46e-47 Blood metabolite levels; BRCA cis rs2777491 0.874 rs7161772 chr15:41611066 A/T cg18705301 chr15:41695430 NDUFAF1 -0.62 -14.12 -0.49 1.38e-39 Ulcerative colitis; BRCA cis rs798554 0.704 rs798513 chr7:2782493 C/T cg13628971 chr7:2884303 GNA12 0.39 8.63 0.32 4.98e-17 Height; BRCA cis rs12530845 0.623 rs73721662 chr7:135341314 G/A cg23117316 chr7:135346802 PL-5283 -0.4 -8.2 -0.31 1.35e-15 Red blood cell traits; BRCA cis rs250677 0.687 rs36044 chr5:148441128 T/C cg18129178 chr5:148520854 ABLIM3 -0.58 -11.93 -0.43 9.28e-30 Breast cancer; BRCA cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg05623727 chr3:50126028 RBM5 -0.49 -12.3 -0.44 2.32e-31 Body mass index; BRCA cis rs12530845 0.887 rs79100776 chr7:135315817 G/A cg23117316 chr7:135346802 PL-5283 -0.34 -8.15 -0.31 1.89e-15 Red blood cell traits; BRCA trans rs3857536 0.741 rs4710582 chr6:66939984 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs752010 0.714 rs10890144 chr1:42085397 G/T cg06885757 chr1:42089581 HIVEP3 0.27 9.72 0.36 6.56e-21 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs67460515 0.630 rs7638370 chr3:160921793 G/T cg03342759 chr3:160939853 NMD3 -0.75 -15.82 -0.53 8.19e-48 Parkinson's disease; BRCA cis rs2880765 0.835 rs1872074 chr15:86033184 T/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.27e-17 Coronary artery disease; BRCA cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg15556689 chr8:8085844 FLJ10661 -0.49 -13.93 -0.48 1.04e-38 Mood instability; BRCA cis rs13053817 0.950 rs13056528 chr22:29829333 C/G cg20285224 chr22:29838184 RFPL1S;RFPL1 0.49 9.66 0.36 1.02e-20 Carotid atherosclerosis in HIV infection; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg15112475 chr7:1198522 ZFAND2A -0.42 -8.2 -0.31 1.37e-15 Bronchopulmonary dysplasia; BRCA cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg06108461 chr20:60628389 TAF4 -0.99 -22.33 -0.66 4.6e-82 Body mass index; BRCA cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg12573674 chr2:1569213 NA -0.43 -8.0 -0.3 6.04e-15 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs7615952 0.599 rs6438955 chr3:125730333 C/A cg07211511 chr3:129823064 LOC729375 -0.59 -11.17 -0.4 1.34e-26 Blood pressure (smoking interaction); BRCA trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg03929089 chr4:120376271 NA 0.57 9.25 0.34 3.26e-19 Axial length; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg15242686 chr22:24348715 GSTTP1 -0.36 -8.8 -0.33 1.26e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17539620 0.624 rs62432738 chr6:154835674 T/C cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03526776 chr6:41159608 TREML2 0.39 8.32 0.31 5.46e-16 Alzheimer's disease (late onset); BRCA cis rs7565124 1.000 rs12471796 chr2:20256192 G/A cg23821541 chr2:20251993 LAPTM4A 0.39 8.05 0.3 4.15e-15 Major depressive disorder; BRCA cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg09184832 chr6:79620586 NA -0.41 -8.18 -0.31 1.52e-15 Intelligence (multi-trait analysis); BRCA cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.69 12.14 0.43 1.18e-30 Lung cancer in ever smokers; BRCA cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg08822215 chr16:89438651 ANKRD11 0.38 8.43 0.32 2.32e-16 Multiple myeloma (IgH translocation); BRCA cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.34e-23 Chronic sinus infection; BRCA cis rs72772090 0.710 rs17479052 chr5:96065636 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.59 -0.45 1.28e-32 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1505368 0.505 rs1394781 chr2:213248822 C/T cg16329650 chr2:213403929 ERBB4 -0.33 -8.05 -0.3 4.04e-15 Symmetrical dimethylarginine levels; BRCA trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.83 0.3 2.02e-14 Corneal astigmatism; BRCA cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg11764359 chr7:65958608 NA 0.8 19.31 0.61 8.41e-66 Aortic root size; BRCA cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg15395560 chr15:45543142 SLC28A2 0.3 8.32 0.31 5.52e-16 Uric acid levels; BRCA cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg05283184 chr6:79620031 NA -0.45 -11.47 -0.41 8.17e-28 Intelligence (multi-trait analysis); BRCA cis rs1882538 0.569 rs11562037 chr7:133076885 A/G cg10665199 chr7:133106180 EXOC4 0.46 9.99 0.37 6.16e-22 Intelligence (multi-trait analysis); BRCA cis rs12760731 0.720 rs12048834 chr1:178353998 A/G cg00404053 chr1:178313656 RASAL2 0.69 8.26 0.31 8.46e-16 Obesity-related traits; BRCA cis rs11051970 0.877 rs2728671 chr12:32589715 T/A cg24626660 chr12:32551988 NA 0.29 8.36 0.31 4e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg20908204 chr19:46285434 DMPK -0.28 -8.15 -0.31 1.87e-15 Coronary artery disease; BRCA cis rs7560272 0.723 rs780391 chr2:73703904 C/T cg20560298 chr2:73613845 ALMS1 0.43 11.65 0.42 1.47e-28 Schizophrenia; BRCA cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg26373071 chr5:1325741 CLPTM1L 0.45 10.63 0.39 2.12e-24 Lung cancer; BRCA trans rs1814175 0.533 rs4528310 chr11:49983106 C/T cg03929089 chr4:120376271 NA 0.59 8.14 0.31 2.02e-15 Height; BRCA cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg12193833 chr17:30244370 NA -0.61 -9.25 -0.34 3.32e-19 Hip circumference adjusted for BMI; BRCA cis rs765787 0.530 rs4775844 chr15:45542048 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.58 -0.42 2.68e-28 Uric acid levels; BRCA cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg11764359 chr7:65958608 NA -0.79 -19.17 -0.6 4.65e-65 Aortic root size; BRCA cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg00599163 chr2:162100495 NA 0.27 8.86 0.33 7.95e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.38 8.99 0.34 2.67e-18 Tonsillectomy; BRCA cis rs6750795 0.569 rs1797387 chr2:232414692 A/G cg19187155 chr2:232395269 NMUR1 0.69 17.55 0.57 1.41e-56 Height; BRCA cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg10932868 chr11:921992 NA 0.38 9.27 0.34 2.72e-19 Alzheimer's disease (late onset); BRCA cis rs9733 0.570 rs951281 chr1:150691122 A/C cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs2239547 0.522 rs6792578 chr3:53004604 G/A cg11645453 chr3:52864694 ITIH4 0.45 11.15 0.4 1.71e-26 Schizophrenia; BRCA cis rs40363 0.645 rs250630 chr16:3524242 C/T cg21433313 chr16:3507492 NAT15 0.45 10.04 0.37 4.04e-22 Tuberculosis; BRCA cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg25767906 chr1:53392781 SCP2 0.38 8.71 0.33 2.67e-17 Monocyte count; BRCA cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg11764359 chr7:65958608 NA 0.78 18.53 0.59 1.17e-61 Aortic root size; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg04518342 chr5:131593106 PDLIM4 0.42 10.3 0.38 3.93e-23 Acylcarnitine levels; BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg04267008 chr7:1944627 MAD1L1 -0.46 -9.61 -0.36 1.63e-20 Schizophrenia; BRCA cis rs68170813 0.559 rs17427849 chr7:106864237 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.69 -0.33 2.97e-17 Coronary artery disease; BRCA cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.85e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg03923535 chr7:1197113 ZFAND2A 0.51 10.95 0.4 1.13e-25 Longevity;Endometriosis; BRCA cis rs7267979 1.000 rs7343481 chr20:25300113 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.64 -0.36 1.23e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6942756 0.715 rs6467242 chr7:129001173 T/A cg02491457 chr7:128862824 NA -0.58 -11.97 -0.43 6.09e-30 White matter hyperintensity burden; BRCA cis rs2066819 1.000 rs17118403 chr12:56630067 C/T cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg22963979 chr7:1858916 MAD1L1 -0.39 -7.98 -0.3 6.55e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs2147904 0.934 rs783622 chr1:42366988 C/T cg16685388 chr1:42384056 HIVEP3 -0.31 -8.58 -0.32 7e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs4363385 0.747 rs1577965 chr1:152968294 T/C cg25856811 chr1:152973957 SPRR3 -0.35 -9.22 -0.34 4.35e-19 Inflammatory skin disease; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg05552183 chr6:42928497 GNMT 0.81 19.52 0.61 6.5e-67 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1577917 1.000 rs12208493 chr6:86662267 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.03 -0.3 4.72e-15 Response to antipsychotic treatment; BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26119090 chr2:26468346 HADHA;HADHB -0.77 -13.56 -0.47 5.25e-37 Gut microbiome composition (summer); BRCA cis rs10046574 0.831 rs10261625 chr7:135173544 C/T cg27474649 chr7:135195673 CNOT4 0.6 8.96 0.33 3.59e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg05896524 chr21:47604654 C21orf56 -0.47 -9.57 -0.35 2.35e-20 Testicular germ cell tumor; BRCA trans rs208520 0.690 rs6929762 chr6:66709277 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 20.26 0.63 7.44e-71 Exhaled nitric oxide output; BRCA cis rs7072216 0.763 rs9787550 chr10:100169051 C/T cg26618903 chr10:100175079 PYROXD2 -0.32 -9.16 -0.34 6.79e-19 Metabolite levels; BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg04944784 chr2:26401820 FAM59B -0.69 -11.36 -0.41 2.25e-27 Gut microbiome composition (summer); BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 11.66 0.42 1.3e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4690686 0.538 rs13120287 chr4:177260184 T/C cg17059388 chr4:177262070 NA 0.49 10.02 0.37 4.99e-22 Essential tremor; BRCA trans rs6598955 0.671 rs11579630 chr1:26612297 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.66 -14.65 -0.5 4.29e-42 Obesity-related traits; BRCA cis rs7044106 0.762 rs1158553 chr9:123400974 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.57 11.59 0.42 2.63e-28 Hip circumference adjusted for BMI; BRCA cis rs8180040 1.000 rs11130127 chr3:47398793 C/G cg16586182 chr3:47516702 SCAP 0.62 14.39 0.49 7.23e-41 Colorectal cancer; BRCA cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.89 14.34 0.49 1.28e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10782582 0.593 rs11579752 chr1:76178694 C/T cg03433033 chr1:76189801 ACADM -0.48 -9.11 -0.34 1.04e-18 Daytime sleep phenotypes; BRCA cis rs992157 0.798 rs2382817 chr2:219151218 A/C cg00012203 chr2:219082015 ARPC2 0.49 9.59 0.35 1.91e-20 Colorectal cancer; BRCA trans rs877282 0.898 rs12359731 chr10:759497 A/G cg22713356 chr15:30763199 NA 1.26 24.29 0.69 8.32e-93 Uric acid levels; BRCA cis rs4481887 0.927 rs4523548 chr1:248472399 G/T cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg12927641 chr6:109611667 NA -0.37 -9.17 -0.34 6.27e-19 Reticulocyte fraction of red cells; BRCA cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg01884057 chr2:25150051 NA 0.35 9.25 0.34 3.24e-19 Body mass index; BRCA cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.25 0.31 9.15e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs858239 0.537 rs10279691 chr7:23228387 A/G cg23682824 chr7:23144976 KLHL7 0.35 8.9 0.33 5.77e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs796364 0.577 rs7574287 chr2:200680999 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.34 0.31 4.51e-16 Schizophrenia; BRCA cis rs11690935 1.000 rs312925 chr2:172563922 G/A cg13550731 chr2:172543902 DYNC1I2 -0.92 -31.13 -0.78 3.51e-130 Schizophrenia; BRCA cis rs7727544 0.645 rs272857 chr5:131685297 G/A cg24060327 chr5:131705240 SLC22A5 -0.47 -9.46 -0.35 5.92e-20 Blood metabolite levels; BRCA cis rs2625529 0.586 rs7170456 chr15:72469946 G/C cg16672083 chr15:72433130 SENP8 0.67 16.12 0.54 2.52e-49 Red blood cell count; BRCA cis rs9810890 1.000 rs73196996 chr3:128458416 G/A cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -9.93 -0.37 1.05e-21 Mean corpuscular volume; BRCA cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.71 15.54 0.52 2.06e-46 Hip circumference adjusted for BMI; BRCA trans rs783540 0.500 rs1313494 chr15:83274279 C/T cg16105309 chr15:79090380 ADAMTS7 0.3 7.83 0.3 2.01e-14 Schizophrenia; BRCA cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg22676075 chr6:135203613 NA 0.41 8.28 0.31 7.41e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs10463316 0.709 rs3857426 chr5:150789831 C/A cg03212797 chr5:150827313 SLC36A1 -0.42 -8.21 -0.31 1.25e-15 Metabolite levels (Pyroglutamine); BRCA cis rs3784262 0.669 rs4646642 chr15:58246916 A/G cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.76 -0.36 4.45e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11098499 0.863 rs2127823 chr4:120485670 G/T cg09307838 chr4:120376055 NA 0.69 14.89 0.51 2.79e-43 Corneal astigmatism; BRCA cis rs7586879 0.789 rs36029941 chr2:25127801 C/T cg01884057 chr2:25150051 NA 0.31 7.84 0.3 1.83e-14 Body mass index; BRCA cis rs7178424 0.805 rs5006593 chr15:62250008 T/C cg00456672 chr15:62358751 C2CD4A 0.43 9.9 0.36 1.41e-21 Height; BRCA cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.55 11.76 0.42 4.97e-29 Monocyte percentage of white cells; BRCA cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg12573674 chr2:1569213 NA -0.64 -14.46 -0.5 3.35e-41 IgG glycosylation; BRCA cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg06221963 chr1:154839813 KCNN3 -0.58 -16.31 -0.54 3.02e-50 Prostate cancer; BRCA cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg11833968 chr6:79620685 NA -0.44 -9.81 -0.36 2.92e-21 Intelligence (multi-trait analysis); BRCA cis rs9814567 0.806 rs2888670 chr3:134326684 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.64 -0.55 6.39e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg11952622 chr19:58962976 ZNF324B 0.43 8.81 0.33 1.13e-17 Uric acid clearance; BRCA cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg12310025 chr6:25882481 NA -0.42 -9.55 -0.35 2.8e-20 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg03264133 chr6:25882463 NA -0.53 -11.96 -0.43 7.1e-30 Blood metabolite levels; BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg08280861 chr8:58055591 NA 0.57 8.91 0.33 5.15e-18 Developmental language disorder (linguistic errors); BRCA cis rs2806561 0.929 rs2867315 chr1:23541286 C/T cg12483005 chr1:23474871 LUZP1 -0.37 -8.06 -0.3 3.8e-15 Height; BRCA cis rs10992471 0.528 rs10820975 chr9:95211922 T/G cg14631576 chr9:95140430 CENPP -0.35 -8.73 -0.33 2.23e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs11098499 0.866 rs11098506 chr4:120284971 A/G cg09307838 chr4:120376055 NA 0.65 14.06 0.49 2.52e-39 Corneal astigmatism; BRCA cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22455342 chr2:225449267 CUL3 0.67 17.22 0.56 7.49e-55 IgE levels in asthmatics (D.p. specific); BRCA cis rs3820928 1.000 rs3820928 chr2:227773466 A/G cg11843606 chr2:227700838 RHBDD1 -0.37 -8.42 -0.32 2.51e-16 Pulmonary function; BRCA cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg12011299 chr4:100065546 ADH4 0.49 10.95 0.4 1.12e-25 Smoking initiation; BRCA cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg06784218 chr1:46089804 CCDC17 0.52 12.34 0.44 1.51e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg25208724 chr1:156163844 SLC25A44 1.07 35.26 0.81 4.84e-152 Testicular germ cell tumor; BRCA cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg17366294 chr4:99064904 C4orf37 0.51 11.24 0.41 7.08e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg13944838 chr5:179740914 GFPT2 0.68 14.67 0.5 3.46e-42 Height; BRCA cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg02734326 chr4:10020555 SLC2A9 -0.35 -7.88 -0.3 1.41e-14 Bone mineral density; BRCA cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg13319975 chr6:146136371 FBXO30 -0.37 -8.56 -0.32 8.47e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs11758351 1.000 rs76329209 chr6:26196430 A/G cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg11266682 chr4:10021025 SLC2A9 0.48 12.67 0.45 5.57e-33 Bone mineral density; BRCA cis rs1401999 1.000 rs6443926 chr3:183706630 A/C cg01324343 chr3:183735012 ABCC5 0.83 21.18 0.64 8.22e-76 Anterior chamber depth; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.29 -0.47 9.55e-36 Platelet count; BRCA cis rs7772486 0.597 rs2246132 chr6:146182515 C/G cg05347473 chr6:146136440 FBXO30 0.62 12.15 0.43 1.07e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs7617773 0.780 rs7632297 chr3:48348163 A/C cg11946769 chr3:48343235 NME6 0.69 13.89 0.48 1.67e-38 Coronary artery disease; BRCA cis rs9308433 0.529 rs4655332 chr1:214490756 G/A cg06198575 chr1:214491504 SMYD2 0.58 12.69 0.45 4.46e-33 IgG glycosylation; BRCA cis rs3892630 0.878 rs7246451 chr19:33209614 C/G cg22980127 chr19:33182716 NUDT19 0.89 17.2 0.56 9.34e-55 Red blood cell traits; BRCA cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg09074113 chr2:20870087 GDF7 -0.34 -8.39 -0.32 3.05e-16 Abdominal aortic aneurysm; BRCA trans rs8073060 0.586 rs9303690 chr17:34005513 C/T cg19694781 chr19:47549865 TMEM160 -1.03 -21.74 -0.65 7.58e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.78 0.39 5.41e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1448094 0.690 rs7132879 chr12:86289864 A/G cg19622623 chr12:86230825 RASSF9 -0.28 -7.99 -0.3 6.42e-15 Major depressive disorder; BRCA cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg13852791 chr20:30311386 BCL2L1 0.84 16.5 0.55 3.24e-51 Mean corpuscular hemoglobin; BRCA cis rs9296092 0.517 rs113111213 chr6:33520790 A/G cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.32 0.38 3.41e-23 Motion sickness; BRCA cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg13902645 chr11:5959945 NA -0.47 -10.09 -0.37 2.5e-22 DNA methylation (variation); BRCA cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg24642844 chr7:1081250 C7orf50 -0.94 -12.26 -0.44 3.45e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11955398 0.665 rs11948543 chr5:59918937 T/C cg02684056 chr5:59996105 DEPDC1B 0.39 9.38 0.35 1.13e-19 Intelligence (multi-trait analysis); BRCA cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg24596788 chr1:163392923 NA -0.37 -9.76 -0.36 4.49e-21 Motion sickness; BRCA cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg23711669 chr6:146136114 FBXO30 -0.73 -15.46 -0.52 5.03e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg10253484 chr15:75165896 SCAMP2 -0.54 -10.05 -0.37 3.67e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs4319547 0.737 rs11058226 chr12:122938958 A/G cg05707623 chr12:122985044 ZCCHC8 -0.41 -8.51 -0.32 1.26e-16 Body mass index; BRCA cis rs7301016 1.000 rs11174518 chr12:62902550 T/C cg01804193 chr12:63026212 NA 0.46 7.93 0.3 1.01e-14 IgG glycosylation; BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -12.95 -0.46 3.01e-34 Platelet count; BRCA cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg24110177 chr3:50126178 RBM5 0.39 10.49 0.38 7.16e-24 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs10034623 chr4:120397829 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.48 0.44 3.81e-32 Corneal astigmatism; BRCA cis rs9816226 1.000 rs55835921 chr3:185831474 T/C cg00760338 chr3:185826511 ETV5 -0.52 -8.82 -0.33 1.1e-17 Obesity;Body mass index; BRCA cis rs7493 1.000 rs12026 chr7:95041016 G/C cg21856205 chr7:94953877 PON1 -0.38 -8.05 -0.3 3.96e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9287719 0.649 rs10182589 chr2:10720664 C/T cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.52e-19 Prostate cancer; BRCA cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.58 -0.39 3.1e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg04450456 chr4:17643702 FAM184B 0.38 11.15 0.4 1.66e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg11764359 chr7:65958608 NA 0.77 17.25 0.56 5.26e-55 Aortic root size; BRCA cis rs61931739 0.534 rs1826144 chr12:34094272 A/G cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.35e-26 Morning vs. evening chronotype; BRCA cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg00686598 chr14:53173677 PSMC6 1.25 16.56 0.55 1.56e-51 Alzheimer's disease (late onset); BRCA cis rs17270561 0.583 rs9393661 chr6:25739080 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.81e-18 Iron status biomarkers; BRCA cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg13175981 chr1:150552382 MCL1 0.47 10.51 0.38 5.93e-24 Tonsillectomy; BRCA cis rs6687430 0.562 rs6676491 chr1:10633421 A/C cg17425144 chr1:10567563 PEX14 0.54 12.4 0.44 8.67e-32 Hand grip strength; BRCA cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg02551604 chr5:131831745 NA -0.4 -14.94 -0.51 1.73e-43 Asthma (sex interaction); BRCA cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg24879335 chr3:133465180 TF 0.32 10.83 0.39 3.36e-25 Iron status biomarkers (transferrin levels); BRCA cis rs6665290 0.935 rs1929863 chr1:227195728 C/T cg10327440 chr1:227177885 CDC42BPA -1.16 -50.17 -0.89 8.1e-224 Myeloid white cell count; BRCA cis rs2882667 0.898 rs2882792 chr5:138380480 G/T cg04439458 chr5:138467593 SIL1 -0.33 -8.98 -0.33 3.06e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3008870 0.883 rs2755249 chr1:67493662 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.23 0.64 4.1e-76 Lymphocyte percentage of white cells; BRCA cis rs13095912 1.000 rs6762208 chr3:185331165 A/C cg11274856 chr3:185301563 NA -0.34 -8.5 -0.32 1.34e-16 Systolic blood pressure; BRCA cis rs757110 0.770 rs1557765 chr11:17403639 T/C cg04705435 chr11:17411270 KCNJ11 0.42 9.1 0.34 1.18e-18 Type 2 diabetes; BRCA cis rs10501293 0.529 rs2902301 chr11:43093159 A/T cg03447554 chr11:43094025 NA -0.56 -12.94 -0.46 3.58e-34 Cognitive performance; BRCA cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg22972055 chr7:872293 UNC84A 0.39 8.68 0.32 3.38e-17 Cerebrospinal P-tau181p levels; BRCA trans rs7819412 0.505 rs17726209 chr8:11022185 C/T cg06636001 chr8:8085503 FLJ10661 0.45 8.48 0.32 1.55e-16 Triglycerides; BRCA cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.08 0.37 2.72e-22 Calcium levels; BRCA cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg26384229 chr12:38710491 ALG10B 0.76 16.99 0.56 1.04e-53 Morning vs. evening chronotype; BRCA cis rs3008870 1.000 rs2815371 chr1:67504313 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.9 19.33 0.61 7.02e-66 Lymphocyte percentage of white cells; BRCA cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.43 0.35 7.76e-20 Tonsillectomy; BRCA cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs826838 0.967 rs826870 chr12:39120250 G/A cg26384229 chr12:38710491 ALG10B -0.61 -15.85 -0.53 5.65e-48 Heart rate; BRCA cis rs7829975 0.606 rs891570 chr8:8794454 G/A cg06636001 chr8:8085503 FLJ10661 -0.54 -11.91 -0.43 1.09e-29 Mood instability; BRCA cis rs758324 0.947 rs6886188 chr5:131178252 C/T cg06307176 chr5:131281290 NA 0.53 10.25 0.38 6.22e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7072216 0.763 rs3750601 chr10:100174561 C/A cg26618903 chr10:100175079 PYROXD2 -0.33 -9.64 -0.36 1.31e-20 Metabolite levels; BRCA cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.65 0.61 1.3e-67 Smoking behavior; BRCA cis rs1595825 0.945 rs73056883 chr2:198824638 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.13 -0.31 2.26e-15 Ulcerative colitis; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg03188948 chr7:1209495 NA 0.59 11.13 0.4 1.99e-26 Longevity;Endometriosis; BRCA cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg22862634 chr11:62369728 EML3;MTA2 0.53 10.72 0.39 8.76e-25 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.84 0.42 2.32e-29 Tonsillectomy; BRCA cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg18876405 chr7:65276391 NA -0.63 -15.57 -0.52 1.4300000000000001e-46 Aortic root size; BRCA cis rs79839061 0.520 rs11730111 chr4:942833 C/T cg14530993 chr4:882597 GAK 0.58 9.57 0.35 2.28e-20 Intelligence (multi-trait analysis); BRCA cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.19 0.4 1.17e-26 Bipolar disorder; BRCA cis rs7677751 0.806 rs7678144 chr4:55102425 T/C cg17187183 chr4:55093834 PDGFRA 0.45 9.22 0.34 4.11e-19 Corneal astigmatism; BRCA cis rs2066819 1.000 rs77853814 chr12:56687572 G/T cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs870825 0.587 rs35845099 chr4:185639762 A/G cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.75 0.6 7.86e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg18225595 chr11:63971243 STIP1 0.4 9.79 0.36 3.38e-21 Platelet count; BRCA cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg03452623 chr4:187889614 NA -0.31 -10.06 -0.37 3.36e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs3772130 0.545 rs7340674 chr3:121574215 T/C cg20356878 chr3:121714668 ILDR1 0.43 9.82 0.36 2.65e-21 Cognitive performance; BRCA cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg06115741 chr20:33292138 TP53INP2 0.42 9.48 0.35 4.91e-20 Coronary artery disease; BRCA trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -13.85 -0.48 2.38e-38 Extrinsic epigenetic age acceleration; BRCA cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg14019146 chr3:50243930 SLC38A3 0.38 9.35 0.35 1.45e-19 Body mass index; BRCA trans rs9291683 0.530 rs73227883 chr4:9979279 T/C cg26043149 chr18:55253948 FECH 0.4 8.96 0.33 3.48e-18 Bone mineral density; BRCA cis rs7395581 0.959 rs2279239 chr11:47281780 T/C cg25783544 chr11:47291846 MADD 0.43 9.45 0.35 6.2e-20 HDL cholesterol; BRCA cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.61 -13.47 -0.47 1.45e-36 Chronic sinus infection; BRCA cis rs3849570 0.925 rs2873054 chr3:81888255 A/C cg07356753 chr3:81810745 GBE1 -0.43 -10.19 -0.37 1.04e-22 Waist circumference;Body mass index; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg13628971 chr7:2884303 GNA12 0.46 9.09 0.34 1.2e-18 Height; BRCA cis rs2882667 0.931 rs7720150 chr5:138334069 C/A cg04439458 chr5:138467593 SIL1 -0.35 -9.85 -0.36 2.16e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs3808502 0.605 rs11784572 chr8:11174484 C/G cg06636001 chr8:8085503 FLJ10661 -0.5 -10.43 -0.38 1.25e-23 Neuroticism; BRCA cis rs4629710 0.545 rs11755717 chr6:131547028 A/T cg12606694 chr6:131520996 AKAP7 -0.4 -8.43 -0.32 2.37e-16 Multiple myeloma (IgH translocation); BRCA trans rs9467711 0.659 rs35277236 chr6:26562269 G/T cg01620082 chr3:125678407 NA -0.69 -8.51 -0.32 1.23e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1020064 0.636 rs2576750 chr2:105916635 A/T cg02079111 chr2:105885981 TGFBRAP1 0.41 7.96 0.3 7.75e-15 AIDS; BRCA cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg18964960 chr10:1102726 WDR37 0.66 9.22 0.34 4.25e-19 Eosinophil percentage of granulocytes; BRCA cis rs7408868 0.908 rs757474 chr19:15273624 T/C cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs477692 0.905 rs524545 chr10:131411840 A/C cg05714579 chr10:131428358 MGMT -0.57 -13.54 -0.47 6.91e-37 Response to temozolomide; BRCA cis rs1215050 0.740 rs783932 chr4:98973936 C/G cg05340658 chr4:99064831 C4orf37 -0.48 -10.94 -0.4 1.24e-25 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs74181299 0.684 rs6736728 chr2:65305499 A/G cg05010058 chr2:65284262 CEP68 0.3 7.97 0.3 7.45e-15 Pulse pressure; BRCA cis rs4363385 0.747 rs9919227 chr1:152970867 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.42 -0.35 8e-20 Inflammatory skin disease; BRCA cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 3.02e-25 Bipolar disorder; BRCA cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.35 0.31 4.22e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7737355 0.947 rs193458 chr5:130816284 G/C cg06307176 chr5:131281290 NA 0.54 11.38 0.41 1.86e-27 Life satisfaction; BRCA trans rs1005277 0.579 rs1548255 chr10:38417193 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.16 -0.49 8.76e-40 Extrinsic epigenetic age acceleration; BRCA cis rs10751667 0.666 rs7394992 chr11:980690 G/C cg06064525 chr11:970664 AP2A2 -0.48 -15.6 -0.53 1.04e-46 Alzheimer's disease (late onset); BRCA cis rs17092148 0.836 rs4322911 chr20:33182577 G/A cg16810054 chr20:33298113 TP53INP2 -0.44 -10.1 -0.37 2.3e-22 Neuroticism; BRCA trans rs66887589 0.775 rs6843229 chr4:120424087 T/C cg25214090 chr10:38739885 LOC399744 0.35 8.01 0.3 5.35e-15 Diastolic blood pressure; BRCA cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg15605315 chr1:45957053 TESK2 -0.47 -9.21 -0.34 4.52e-19 High light scatter reticulocyte count; BRCA cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg21573476 chr21:45109991 RRP1B -0.39 -10.44 -0.38 1.14e-23 Mean corpuscular volume; BRCA cis rs2858942 0.602 rs1211375 chr16:240280 G/T cg08400316 chr16:204221 HBZ -0.37 -8.08 -0.3 3.32e-15 Mean corpuscular hemoglobin; BRCA trans rs5756813 1.000 rs1129448 chr22:38170026 G/A cg19894588 chr14:64061835 NA 0.54 13.82 0.48 3.47e-38 Optic cup area;Vertical cup-disc ratio; BRCA cis rs12368653 0.544 rs11172304 chr12:58097862 T/C cg18357645 chr12:58087776 OS9 0.41 11.96 0.43 6.59e-30 Multiple sclerosis; BRCA trans rs35110281 0.667 rs4818859 chr21:45117120 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.76 0.33 1.77e-17 Mean corpuscular volume; BRCA cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg05665937 chr4:1216051 CTBP1 0.43 8.62 0.32 5.41e-17 Obesity-related traits; BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 16.85 0.55 5.43e-53 Alzheimer's disease; BRCA trans rs7615952 0.673 rs9821905 chr3:125620850 A/G cg07211511 chr3:129823064 LOC729375 0.99 13.89 0.48 1.6e-38 Blood pressure (smoking interaction); BRCA cis rs775227 0.574 rs13064411 chr3:113046640 A/G cg18753928 chr3:113234510 CCDC52 -0.59 -9.24 -0.34 3.54e-19 Dental caries; BRCA trans rs7615952 0.932 rs11922218 chr3:125631289 C/T cg07211511 chr3:129823064 LOC729375 -1.01 -19.21 -0.61 3.06e-65 Blood pressure (smoking interaction); BRCA cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg24130564 chr14:104152367 KLC1 -0.39 -8.91 -0.33 5.2e-18 Intelligence (multi-trait analysis); BRCA cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg05623727 chr3:50126028 RBM5 -0.49 -11.69 -0.42 9.64e-29 Body mass index; BRCA cis rs10754283 0.967 rs4658130 chr1:90113447 G/C cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6754311 0.517 rs1469995 chr2:136542559 G/A cg07169764 chr2:136633963 MCM6 0.99 19.92 0.62 4.78e-69 Mosquito bite size; BRCA cis rs73198271 0.740 rs10105690 chr8:8649232 G/T cg15556689 chr8:8085844 FLJ10661 -0.32 -7.85 -0.3 1.81e-14 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg27286337 chr10:134555280 INPP5A 0.6 10.15 0.37 1.51e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg08885076 chr2:99613938 TSGA10 -0.48 -9.26 -0.34 3.18e-19 Chronic sinus infection; BRCA cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg11941060 chr3:133502564 NA -0.5 -11.87 -0.43 1.61e-29 Iron status biomarkers; BRCA cis rs35740288 1.000 rs35740288 chr15:86297085 T/A cg20737812 chr15:86336631 KLHL25 -0.33 -8.82 -0.33 1.07e-17 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs9462027 0.628 rs2764206 chr6:34712900 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.54e-14 Systemic lupus erythematosus; BRCA trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.72e-20 Morning vs. evening chronotype; BRCA cis rs9309711 0.922 rs13431788 chr2:3482912 G/A cg16153549 chr2:3496821 NA -0.41 -9.38 -0.35 1.13e-19 Neurofibrillary tangles; BRCA cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg06627557 chr7:32535165 LSM5;AVL9 -1.07 -30.59 -0.77 2.77e-127 Cognitive ability; BRCA cis rs2832191 0.791 rs8134407 chr21:30476586 G/A cg08807101 chr21:30365312 RNF160 0.59 15.17 0.51 1.26e-44 Dental caries; BRCA cis rs1865760 0.827 rs9295680 chr6:25944103 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.72 0.36 6.51e-21 Height; BRCA cis rs7100689 0.784 rs7082102 chr10:82104890 A/C cg01528321 chr10:82214614 TSPAN14 0.91 19.98 0.62 2.21e-69 Post bronchodilator FEV1; BRCA trans rs11098499 0.779 rs6815934 chr4:120267310 T/C cg25214090 chr10:38739885 LOC399744 0.43 10.0 0.37 5.45e-22 Corneal astigmatism; BRCA cis rs921968 0.541 rs642520 chr2:219423605 A/G cg10223061 chr2:219282414 VIL1 0.27 7.96 0.3 7.8e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs9858542 0.953 rs9878943 chr3:49434654 G/A cg03060546 chr3:49711283 APEH -0.51 -10.42 -0.38 1.34e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6733011 0.506 rs11123755 chr2:99507948 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.35 -8.1 -0.31 2.72e-15 Bipolar disorder; BRCA cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg26769984 chr7:1090371 C7orf50 0.44 9.47 0.35 5.3e-20 Bronchopulmonary dysplasia; BRCA cis rs6598955 0.671 rs75517917 chr1:26612926 G/T cg00852783 chr1:26633632 UBXN11 -0.5 -8.26 -0.31 8.7e-16 Obesity-related traits; BRCA cis rs7737355 0.947 rs31587 chr5:131000711 A/T cg06307176 chr5:131281290 NA 0.53 10.41 0.38 1.51e-23 Life satisfaction; BRCA cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 13.8 0.48 4.37e-38 Response to bleomycin (chromatid breaks); BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs7246657 0.943 rs3745765 chr19:37854235 G/T cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -26.1 -0.72 9.5e-103 Chronic sinus infection; BRCA cis rs7044106 0.791 rs735110 chr9:123488940 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.78 18.12 0.58 1.51e-59 Hip circumference adjusted for BMI; BRCA cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg03477792 chr4:77819574 ANKRD56 0.52 11.69 0.42 9.73e-29 Emphysema distribution in smoking; BRCA cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.56 -0.32 8.47e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs17818399 0.735 rs11894342 chr2:46836439 A/T cg02822958 chr2:46747628 ATP6V1E2 0.42 8.62 0.32 5.28e-17 Height; BRCA cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08704250 chr15:31115839 NA -0.36 -9.07 -0.34 1.43e-18 Huntington's disease progression; BRCA cis rs782590 0.875 rs62165175 chr2:55745810 T/A cg18811423 chr2:55921094 PNPT1 0.67 19.88 0.62 7.72e-69 Metabolic syndrome; BRCA cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg22875332 chr1:76189707 ACADM -0.54 -10.34 -0.38 2.74e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg16145915 chr7:1198662 ZFAND2A -0.47 -10.66 -0.39 1.63e-24 Longevity;Endometriosis; BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.31 -0.38 3.63e-23 Gut microbiome composition (summer); BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.13 -0.4 1.96e-26 Lymphocyte counts; BRCA trans rs3733585 0.673 rs7376505 chr4:9952744 C/A cg26043149 chr18:55253948 FECH -0.37 -8.13 -0.31 2.18e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs911555 0.755 rs12432803 chr14:103930032 C/T cg12935359 chr14:103987150 CKB 0.64 14.67 0.5 3.48e-42 Intelligence (multi-trait analysis); BRCA cis rs6598955 0.671 rs11247896 chr1:26600483 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs9394841 0.692 rs56215622 chr6:41892457 G/A cg08135965 chr6:41755394 TOMM6 0.51 8.44 0.32 2.17e-16 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.29 -0.38 4.31e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg01256987 chr12:42539512 GXYLT1 -0.56 -11.49 -0.41 6.43e-28 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6866344 0.561 rs55974982 chr5:178141421 G/A cg10224037 chr5:178157518 ZNF354A 0.79 17.9 0.58 2.18e-58 Neutrophil percentage of white cells; BRCA cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg26384229 chr12:38710491 ALG10B 0.69 16.21 0.54 9.67e-50 Bladder cancer; BRCA cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -9.83 -0.36 2.39e-21 Schizophrenia; BRCA cis rs9649213 0.614 rs1006169 chr7:97938443 A/G cg09267113 chr7:98030324 BAIAP2L1 0.58 15.4 0.52 9.2e-46 Prostate cancer (SNP x SNP interaction); BRCA cis rs9400271 0.609 rs9386782 chr6:109588643 G/T cg01475377 chr6:109611718 NA -0.44 -10.41 -0.38 1.56e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs9467773 1.000 rs6925703 chr6:26521589 G/A cg11502198 chr6:26597334 ABT1 0.48 9.54 0.35 3.06e-20 Intelligence (multi-trait analysis); BRCA cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg17211192 chr8:82754475 SNX16 -0.51 -11.71 -0.42 7.97e-29 Diastolic blood pressure; BRCA cis rs8180040 1.000 rs7613282 chr3:47389409 C/T cg16586182 chr3:47516702 SCAP 0.62 14.49 0.5 2.41e-41 Colorectal cancer; BRCA cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg02012338 chr4:187126139 CYP4V2 0.85 9.6 0.35 1.82e-20 Blood protein levels; BRCA cis rs2731664 0.792 rs2544809 chr5:176885499 T/C cg23176889 chr5:176863531 GRK6 -0.64 -17.72 -0.57 1.82e-57 Intelligence (multi-trait analysis); BRCA cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg06713675 chr4:122721982 EXOSC9 -0.53 -12.44 -0.44 5.58e-32 Type 2 diabetes; BRCA trans rs35110281 0.811 rs9980185 chr21:45057905 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.06 0.37 3.27e-22 Mean corpuscular volume; BRCA cis rs7737355 0.947 rs1422081 chr5:130776053 A/C cg06307176 chr5:131281290 NA 0.5 9.92 0.37 1.12e-21 Life satisfaction; BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.06 0.34 1.52e-18 Tonsillectomy; BRCA cis rs6867032 1.000 rs4975794 chr5:2015330 A/G cg26168224 chr5:2018326 NA -0.64 -18.47 -0.59 2.39e-61 Gut microbiome composition (winter); BRCA trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.11 -18.14 -0.58 1.28e-59 Hemostatic factors and hematological phenotypes; BRCA cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg12386194 chr3:101231763 SENP7 0.46 9.91 0.36 1.29e-21 Colorectal cancer; BRCA trans rs2562456 0.917 rs2681389 chr19:21692575 G/A cg25042112 chr7:64838748 ZNF92 0.46 8.63 0.32 4.86e-17 Pain; BRCA cis rs2625529 0.530 rs2959930 chr15:72598614 A/G cg16672083 chr15:72433130 SENP8 -0.71 -15.2 -0.52 9.33e-45 Red blood cell count; BRCA cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg24112000 chr20:60950667 NA -0.5 -9.67 -0.36 1.01e-20 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs10411936 0.692 rs10413787 chr19:16594967 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.72 0.36 6.35e-21 White blood cell count;Multiple sclerosis; BRCA cis rs11758351 0.778 rs41266801 chr6:26197493 C/A cg01420254 chr6:26195488 NA 0.6 9.24 0.34 3.6e-19 Gout;Renal underexcretion gout; BRCA cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg11890956 chr21:40555474 PSMG1 1.03 27.92 0.74 9.19e-113 Cognitive function; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg11843238 chr5:131593191 PDLIM4 0.44 11.34 0.41 2.81e-27 Acylcarnitine levels; BRCA cis rs4474465 1.000 rs6592779 chr11:78197283 G/C cg27205649 chr11:78285834 NARS2 -0.32 -8.83 -0.33 9.82e-18 Alzheimer's disease (survival time); BRCA cis rs4908760 0.899 rs61783642 chr1:8591397 T/C cg20416874 chr1:8611966 RERE -0.28 -8.02 -0.3 5.12e-15 Vitiligo; BRCA cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg25833597 chr17:30823145 MYO1D 0.34 8.34 0.31 4.72e-16 Schizophrenia; BRCA cis rs9868809 0.505 rs28657585 chr3:48736216 A/T cg00383909 chr3:49044727 WDR6 0.59 11.07 0.4 3.56e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs12474201 0.928 rs13025984 chr2:46938789 T/C cg06386533 chr2:46925753 SOCS5 0.87 18.93 0.6 8.6e-64 Height; BRCA cis rs3925075 1.000 rs3925075 chr16:31347748 C/T cg02846316 chr16:31340340 ITGAM -0.54 -13.45 -0.47 1.8e-36 IgA nephropathy; BRCA cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg15145296 chr3:125709740 NA -0.57 -9.37 -0.35 1.19e-19 Blood pressure (smoking interaction); BRCA cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg05707623 chr12:122985044 ZCCHC8 0.44 8.77 0.33 1.67e-17 Body mass index; BRCA cis rs1451375 1.000 rs4452748 chr7:50625056 A/C cg18232548 chr7:50535776 DDC -0.43 -10.12 -0.37 2.02e-22 Malaria; BRCA trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg20587970 chr11:113659929 NA -1.2 -22.13 -0.66 5.45e-81 Hip circumference adjusted for BMI; BRCA cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg20503657 chr10:835505 NA 0.93 14.38 0.49 8.36e-41 Eosinophil percentage of granulocytes; BRCA cis rs9814567 1.000 rs11928499 chr3:134232350 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.42 0.32 2.42e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 26.21 0.72 2.25e-103 Chronic sinus infection; BRCA cis rs782590 0.837 rs782573 chr2:55912961 T/C cg18811423 chr2:55921094 PNPT1 0.77 26.87 0.73 5.06e-107 Metabolic syndrome; BRCA cis rs887829 0.569 rs7574296 chr2:234638249 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.99 -0.34 2.76e-18 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs56399783 0.901 rs73047393 chr7:2775879 C/T cg23627948 chr7:2760692 NA 0.49 8.04 0.3 4.21e-15 Childhood ear infection; BRCA cis rs12545109 0.800 rs1561224 chr8:57419922 T/C cg09654669 chr8:57350985 NA -0.39 -8.59 -0.32 6.42e-17 Obesity-related traits; BRCA cis rs56176327 0.583 rs7613603 chr3:49812866 C/T cg03060546 chr3:49711283 APEH -0.59 -10.21 -0.37 9.07e-23 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg11266682 chr4:10021025 SLC2A9 -0.38 -10.02 -0.37 4.61e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6973256 0.828 rs4731974 chr7:133344010 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.510 rs10752902 chr1:183090265 T/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg15112475 chr7:1198522 ZFAND2A -0.62 -16.35 -0.54 1.96e-50 Longevity;Endometriosis; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg02353165 chr6:42928485 GNMT 0.89 23.98 0.69 3.97e-91 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg03806693 chr22:41940476 POLR3H -1.15 -22.86 -0.67 5.77e-85 Vitiligo; BRCA cis rs11711311 1.000 rs12736 chr3:113530211 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -10.2 -0.37 9.61e-23 IgG glycosylation; BRCA cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs36051895 0.559 rs10815172 chr9:5212254 T/A cg02405213 chr9:5042618 JAK2 -0.45 -8.61 -0.32 5.59e-17 Pediatric autoimmune diseases; BRCA cis rs35306767 0.623 rs72760941 chr10:1141244 A/G cg26597838 chr10:835615 NA 0.68 10.89 0.4 1.82e-25 Eosinophil percentage of granulocytes; BRCA cis rs61931739 0.500 rs11519398 chr12:34473553 C/T cg06521331 chr12:34319734 NA -0.54 -9.36 -0.35 1.39e-19 Morning vs. evening chronotype; BRCA cis rs9399135 0.967 rs952674 chr6:135349157 A/G cg24558204 chr6:135376177 HBS1L 0.44 12.2 0.43 6.19e-31 Red blood cell count; BRCA cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs8054556 0.669 rs9972866 chr16:30018982 C/G cg06326092 chr16:30034487 C16orf92 0.35 8.76 0.33 1.8e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.64 9.94 0.37 9.42e-22 Lung function (FEV1/FVC); BRCA cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg02640540 chr1:67518911 SLC35D1 0.51 11.18 0.4 1.27e-26 Lymphocyte percentage of white cells; BRCA cis rs2882667 0.690 rs176381 chr5:138196731 C/T cg04439458 chr5:138467593 SIL1 0.31 7.97 0.3 7.43e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg01819759 chr13:79234251 RNF219 0.66 11.7 0.42 8.78e-29 Large artery stroke; BRCA cis rs2882667 0.690 rs288017 chr5:138193515 A/T cg04439458 chr5:138467593 SIL1 0.35 8.57 0.32 7.79e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4891159 0.756 rs8084155 chr18:74134952 A/G cg24786174 chr18:74118243 ZNF516 -0.81 -22.62 -0.67 1.08e-83 Longevity; BRCA cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -9.44 -0.35 6.86e-20 Personality dimensions; BRCA cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg11663144 chr21:46675770 NA -0.49 -9.54 -0.35 2.92e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs61931739 0.534 rs11053029 chr12:34131766 G/T cg13010199 chr12:38710504 ALG10B 0.48 9.29 0.34 2.41e-19 Morning vs. evening chronotype; BRCA cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg13334819 chr7:99746414 C7orf59 -0.36 -8.1 -0.31 2.73e-15 Coronary artery disease; BRCA cis rs1997103 1.000 rs6973337 chr7:55411534 T/C cg17469321 chr7:55412551 NA 0.51 9.68 0.36 8.77e-21 QRS interval (sulfonylurea treatment interaction); BRCA trans rs6598955 0.671 rs7550997 chr1:26596080 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.65 -14.98 -0.51 1.04e-43 Obesity-related traits; BRCA cis rs7512552 0.839 rs2264418 chr1:150368579 G/A cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.96e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7592578 0.599 rs62180992 chr2:191285732 A/G cg11845111 chr2:191398756 TMEM194B -0.75 -13.49 -0.47 1.17e-36 Diastolic blood pressure; BRCA cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg08917208 chr2:24149416 ATAD2B 0.9 13.2 0.46 2.27e-35 Lymphocyte counts; BRCA cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg24531977 chr5:56204891 C5orf35 -1.0 -20.39 -0.63 1.43e-71 Initial pursuit acceleration; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg08470875 chr2:26401718 FAM59B -0.68 -11.68 -0.42 1.05e-28 Gut microbiome composition (summer); BRCA cis rs2745967 0.715 rs2724367 chr1:208067329 C/T cg09788693 chr1:208063733 CD34 0.37 7.84 0.3 1.86e-14 Resting heart rate; BRCA trans rs6582630 0.537 rs11611326 chr12:38547958 C/A cg06521331 chr12:34319734 NA -0.51 -9.27 -0.34 2.75e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg21782813 chr7:2030301 MAD1L1 0.29 7.94 0.3 9.15e-15 Bipolar disorder and schizophrenia; BRCA cis rs11711311 1.000 rs2603793 chr3:113496418 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.37 9.67 0.36 1.02e-20 IgG glycosylation; BRCA cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg20476274 chr7:133979776 SLC35B4 0.7 21.25 0.64 3.26e-76 Mean platelet volume; BRCA cis rs9399135 0.967 rs9389258 chr6:135361140 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.74e-31 Red blood cell count; BRCA cis rs9837602 0.938 rs34922392 chr3:99794730 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 10.46 0.38 9.25e-24 Breast cancer; BRCA cis rs9463078 0.683 rs227851 chr6:44699209 A/C cg25276700 chr6:44698697 NA 0.35 7.81 0.3 2.39e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs312274 0.515 rs2583992 chr12:41241863 C/T cg17827154 chr12:41323612 CNTN1 0.36 8.84 0.33 9.34e-18 Metabolite levels (X-11787); BRCA cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16024904 chr19:17905718 B3GNT3 0.37 7.81 0.3 2.38e-14 Tumor biomarkers; BRCA cis rs7247513 0.701 rs8107642 chr19:12766370 C/T cg01871581 chr19:12707946 ZNF490 -0.64 -14.39 -0.49 6.83e-41 Bipolar disorder; BRCA cis rs922182 0.617 rs17777266 chr15:64241242 A/G cg24729988 chr15:64271149 DAPK2 0.49 10.87 0.39 2.34e-25 Blood protein levels; BRCA cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg21770322 chr7:97807741 LMTK2 0.41 11.02 0.4 5.9e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs9341808 0.718 rs2322636 chr6:80897436 C/T cg08355045 chr6:80787529 NA 0.39 9.91 0.36 1.26e-21 Sitting height ratio; BRCA cis rs2019216 0.835 rs402052 chr17:21908388 G/C cg22648282 chr17:21454238 C17orf51 -0.36 -8.07 -0.3 3.6e-15 Pelvic organ prolapse; BRCA cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg18230493 chr5:56204884 C5orf35 -0.73 -14.31 -0.49 1.77e-40 Initial pursuit acceleration; BRCA cis rs61935443 0.666 rs11107780 chr12:95299142 G/A cg21533806 chr12:95267307 NA 0.47 8.16 0.31 1.77e-15 Schizophrenia; BRCA cis rs753274 0.650 rs72998945 chr19:14418441 C/A cg25450033 chr19:14444658 NA 0.33 7.82 0.3 2.23e-14 Tumor necrosis factor beta levels; BRCA cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg26373071 chr5:1325741 CLPTM1L 0.49 11.78 0.42 4.06e-29 Lung cancer; BRCA cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg27529037 chr20:44575021 PCIF1 0.32 7.84 0.3 1.96e-14 Intelligence (multi-trait analysis); BRCA cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg17330251 chr7:94953956 PON1 -0.43 -8.6 -0.32 5.91e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg14847009 chr1:175162515 KIAA0040 0.25 9.65 0.36 1.14e-20 Alcohol dependence; BRCA cis rs72772090 0.539 rs72775807 chr5:96179761 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -11.31 -0.41 3.56e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg00701064 chr4:6280414 WFS1 0.65 16.41 0.54 8.8e-51 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg13319975 chr6:146136371 FBXO30 0.34 7.94 0.3 9.3e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs17253792 0.822 rs17253716 chr14:56153661 G/C cg01858014 chr14:56050164 KTN1 -0.76 -9.53 -0.35 3.34e-20 Putamen volume; BRCA cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -12.51 -0.44 2.77e-32 Hemoglobin concentration; BRCA cis rs757081 0.667 rs17641418 chr11:17161341 T/C cg15432903 chr11:17409602 KCNJ11 -0.47 -8.81 -0.33 1.17e-17 Systolic blood pressure; BRCA cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg03433033 chr1:76189801 ACADM 0.75 17.08 0.56 3.59e-54 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg01475377 chr6:109611718 NA -0.51 -12.99 -0.46 2.1e-34 Reticulocyte fraction of red cells; BRCA cis rs4891159 0.790 rs1056714 chr18:74149526 A/G cg24786174 chr18:74118243 ZNF516 -0.74 -18.11 -0.58 1.84e-59 Longevity; BRCA cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg08601574 chr20:25228251 PYGB -0.36 -8.53 -0.32 1.03e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs875971 0.545 rs17138156 chr7:65714695 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.24 0.38 6.64e-23 Aortic root size; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.81 0.36 3e-21 Gut microbiome composition (summer); BRCA cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg14863265 chr7:2801509 GNA12 -0.42 -9.64 -0.36 1.21e-20 Height; BRCA cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg17724175 chr1:150552817 MCL1 0.25 8.42 0.32 2.49e-16 Tonsillectomy; BRCA cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.29 0.47 9e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.43 -9.39 -0.35 1.07e-19 Colorectal cancer; BRCA cis rs4809760 0.692 rs8118160 chr20:48434636 A/G cg17835207 chr20:48524531 SPATA2 0.38 8.3 0.31 6.18e-16 Gut microbiota (beta diversity); BRCA cis rs6088590 0.582 rs6059909 chr20:33139691 C/A cg06115741 chr20:33292138 TP53INP2 0.41 8.94 0.33 4e-18 Coronary artery disease; BRCA cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg04287289 chr16:89883240 FANCA -0.61 -13.94 -0.48 9.47e-39 Vitiligo; BRCA cis rs7258465 0.965 rs10408290 chr19:18542701 C/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.76 -0.33 1.76e-17 Breast cancer; BRCA cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs2243480 0.522 rs73150635 chr7:65972490 C/T cg18252515 chr7:66147081 NA -1.0 -11.23 -0.41 7.95e-27 Diabetic kidney disease; BRCA cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg06484146 chr7:12443880 VWDE -0.76 -10.77 -0.39 5.66e-25 Coronary artery disease; BRCA cis rs6598955 0.627 rs6684875 chr1:26567044 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.38 0.57 1.11e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs2354432 1.000 rs10900325 chr1:146692174 C/T cg25205988 chr1:146714368 CHD1L -0.93 -15.28 -0.52 3.67e-45 Mitochondrial DNA levels; BRCA cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs72772090 0.634 rs17401901 chr5:96091925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -13.46 -0.47 1.57e-36 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8005677 0.926 rs34344888 chr14:23387585 A/G cg01529538 chr14:23388837 RBM23 0.42 11.48 0.41 7.01e-28 Cognitive ability (multi-trait analysis); BRCA cis rs10046574 0.831 rs10276768 chr7:135064346 A/G cg27474649 chr7:135195673 CNOT4 0.58 8.3 0.31 6.41e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11030122 0.632 rs4910596 chr11:4084604 A/G cg18678763 chr11:4115507 RRM1 -0.35 -7.88 -0.3 1.37e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg14440974 chr22:39074834 NA -0.38 -9.14 -0.34 8.06e-19 Menopause (age at onset); BRCA cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg24006582 chr15:45444508 DUOX1 -0.56 -11.55 -0.42 3.82e-28 Uric acid levels; BRCA cis rs929596 0.614 rs10929302 chr2:234665782 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -12.03 -0.43 3.53e-30 Total bilirubin levels in HIV-1 infection; BRCA cis rs490234 0.702 rs2416964 chr9:128360413 C/T cg14078157 chr9:128172775 NA -0.48 -10.75 -0.39 7.08e-25 Mean arterial pressure; BRCA cis rs10465746 0.780 rs12139191 chr1:84387871 A/C cg10977910 chr1:84465055 TTLL7 0.58 12.06 0.43 2.57e-30 Obesity-related traits; BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -12.29 -0.44 2.72e-31 Bipolar disorder and schizophrenia; BRCA cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg11952622 chr19:58962976 ZNF324B -0.5 -10.71 -0.39 9.77e-25 Uric acid clearance; BRCA cis rs7267979 0.932 rs372678 chr20:25465248 G/A cg08601574 chr20:25228251 PYGB 0.33 8.2 0.31 1.3e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs875971 0.862 rs778724 chr7:65829291 T/C cg18876405 chr7:65276391 NA 0.52 11.74 0.42 5.66e-29 Aortic root size; BRCA trans rs11098499 0.775 rs10021601 chr4:120282563 G/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg15017067 chr4:17643749 FAM184B -0.28 -7.83 -0.3 1.99e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7246657 0.943 rs7255785 chr19:37971683 C/T cg23950597 chr19:37808831 NA -0.62 -11.59 -0.42 2.48e-28 Coronary artery calcification; BRCA cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg10349874 chr16:420996 TMEM8A;MRPL28 0.35 8.45 0.32 2.04e-16 Bone mineral density (spine);Bone mineral density; BRCA cis rs3849570 1.000 rs3772882 chr3:81808602 C/A cg07356753 chr3:81810745 GBE1 -0.45 -10.63 -0.39 2.14e-24 Waist circumference;Body mass index; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg23978390 chr7:1156363 C7orf50 0.38 9.12 0.34 9.98e-19 Longevity;Endometriosis; BRCA cis rs72772090 0.522 rs76590269 chr5:95996410 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -8.5 -0.32 1.3e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.86 0.45 7.85e-34 Bipolar disorder; BRCA cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg10523679 chr1:76189770 ACADM 0.78 18.71 0.59 1.25e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg15485101 chr11:133734466 NA -0.42 -10.48 -0.38 8.34e-24 Childhood ear infection; BRCA trans rs208520 1.000 rs72882100 chr6:66981495 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.51 0.5 1.93e-41 Exhaled nitric oxide output; BRCA cis rs12579753 0.917 rs7138895 chr12:82203280 T/G cg07988820 chr12:82153109 PPFIA2 -0.48 -8.4 -0.32 2.96e-16 Resting heart rate; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg15112475 chr7:1198522 ZFAND2A -0.53 -11.52 -0.41 4.96e-28 Longevity;Endometriosis; BRCA cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg06547715 chr2:218990976 CXCR2 0.32 7.89 0.3 1.3e-14 Ulcerative colitis; BRCA cis rs7264396 0.635 rs6058355 chr20:34491343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.73 -0.5 1.74e-42 Total cholesterol levels; BRCA cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg18876405 chr7:65276391 NA 0.71 18.61 0.59 4.39e-62 Calcium levels; BRCA cis rs826838 1.000 rs826892 chr12:39100790 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.18 -0.54 1.39e-49 Heart rate; BRCA cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.76 0.36 4.62e-21 Bipolar disorder; BRCA cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg18016565 chr1:150552671 MCL1 0.35 8.43 0.32 2.25e-16 Tonsillectomy; BRCA cis rs701145 0.585 rs1727953 chr3:153871392 G/T cg17054900 chr3:154042577 DHX36 0.55 9.34 0.35 1.58e-19 Coronary artery disease; BRCA cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg16339924 chr4:17578868 LAP3 0.58 13.97 0.48 6.48e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10752881 0.875 rs10797825 chr1:183024581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.3e-51 Colorectal cancer; BRCA cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.14 0.46 4.34e-35 Bipolar disorder; BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Menopause (age at onset); BRCA cis rs701145 0.556 rs355771 chr3:154039385 G/C cg12800244 chr3:153838788 SGEF 0.44 8.66 0.32 3.98e-17 Coronary artery disease; BRCA cis rs7011049 1.000 rs72643577 chr8:53846358 A/T cg26025543 chr8:53854495 NA 0.55 9.57 0.35 2.31e-20 Systolic blood pressure; BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg24642844 chr7:1081250 C7orf50 -0.74 -13.87 -0.48 1.88e-38 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4363385 0.818 rs1048296 chr1:153012240 A/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.82 -13.66 -0.48 1.78e-37 Platelet count; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg23708337 chr7:1209742 NA 0.64 8.74 0.33 2.05e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1372520 0.684 rs2619347 chr4:90745770 G/A cg15133208 chr4:90757351 SNCA -0.38 -7.82 -0.3 2.14e-14 Neuroticism; BRCA cis rs7833986 0.501 rs72653978 chr8:57018393 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.69 12.93 0.46 3.74e-34 Height; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.6 -12.55 -0.44 1.86e-32 Lymphocyte counts; BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.29 -0.31 6.69e-16 Gut microbiome composition (summer); BRCA cis rs290268 0.838 rs1333635 chr9:93566406 A/G cg02608019 chr9:93564028 SYK 0.56 12.4 0.44 8.82e-32 Platelet count; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg18301423 chr5:131593218 PDLIM4 0.35 8.75 0.33 1.93e-17 Acylcarnitine levels; BRCA cis rs921968 0.541 rs2556391 chr2:219556346 T/C cg10223061 chr2:219282414 VIL1 0.28 7.94 0.3 8.93e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.41 -0.47 2.55e-36 Developmental language disorder (linguistic errors); BRCA cis rs757110 0.770 rs4439492 chr11:17386733 C/T cg04705435 chr11:17411270 KCNJ11 0.44 9.4 0.35 9.82e-20 Type 2 diabetes; BRCA cis rs1691799 0.836 rs1184552 chr12:66756215 A/G cg16791601 chr12:66731901 HELB -0.66 -18.01 -0.58 6.19e-59 White blood cell count (basophil); BRCA cis rs6547741 0.874 rs28381983 chr2:27804432 T/C cg27432699 chr2:27873401 GPN1 0.45 9.3 0.35 2.19e-19 Oral cavity cancer; BRCA cis rs12478296 1.000 rs4973685 chr2:243019089 A/C cg06360820 chr2:242988706 NA -0.85 -15.11 -0.51 2.45e-44 Obesity-related traits; BRCA cis rs7267979 0.844 rs2257649 chr20:25263457 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.28 7.85 0.3 1.74e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7267979 1.000 rs448396 chr20:25440269 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4363385 0.693 rs608509 chr1:153034650 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.3 -0.31 6.2e-16 Inflammatory skin disease; BRCA cis rs6901250 0.851 rs339362 chr6:117165370 A/C cg12892004 chr6:117198278 RFX6 -0.5 -11.43 -0.41 1.15e-27 C-reactive protein levels; BRCA trans rs11577318 0.853 rs12743998 chr1:26629882 G/A cg07461501 chr17:79650226 HGS;ARL16 0.4 10.09 0.37 2.53e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg02951883 chr7:2050386 MAD1L1 -0.57 -13.19 -0.46 2.53e-35 Bipolar disorder and schizophrenia; BRCA cis rs8062405 1.000 rs62036616 chr16:28826307 A/G cg09754948 chr16:28834200 ATXN2L 0.46 8.59 0.32 6.53e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7560272 0.723 rs7566315 chr2:73791808 C/T cg20560298 chr2:73613845 ALMS1 -0.41 -11.52 -0.41 5.08e-28 Schizophrenia; BRCA cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg03146154 chr1:46216737 IPP 0.45 10.04 0.37 4.15e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4660306 0.884 rs7543076 chr1:45964238 T/C cg24296786 chr1:45957014 TESK2 0.42 8.42 0.32 2.52e-16 Homocysteine levels; BRCA cis rs7833986 0.501 rs2719258 chr8:56941389 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.67 13.11 0.46 5.97e-35 Height; BRCA trans rs2204008 0.774 rs8189620 chr12:38241621 A/G cg06521331 chr12:34319734 NA -0.52 -9.35 -0.35 1.41e-19 Bladder cancer; BRCA cis rs1801251 1.000 rs991873 chr2:233711046 A/G cg25237894 chr2:233734115 C2orf82 -0.41 -11.81 -0.42 3.04e-29 Coronary artery disease; BRCA cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.29 -0.38 4.31e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg04450456 chr4:17643702 FAM184B -0.34 -9.9 -0.36 1.4e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.95 14.43 0.5 4.75e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg08847533 chr14:75593920 NEK9 -0.84 -21.75 -0.65 6.46e-79 Height; BRCA trans rs4332037 0.624 rs56256289 chr7:1892529 C/T cg25206134 chr2:45395956 NA 0.53 8.94 0.33 4.23e-18 Bipolar disorder; BRCA cis rs6840360 0.571 rs62327270 chr4:152533618 C/T cg22705602 chr4:152727874 NA -0.33 -8.26 -0.31 8.67e-16 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.08 0.43 2.16e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg15485101 chr11:133734466 NA -0.39 -9.87 -0.36 1.81e-21 Childhood ear infection; BRCA cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg24642439 chr20:33292090 TP53INP2 0.69 15.6 0.53 9.49e-47 Coronary artery disease; BRCA cis rs8062405 0.755 rs56272201 chr16:28580685 A/G cg16576597 chr16:28551801 NUPR1 0.35 8.8 0.33 1.32e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6121246 0.559 rs6121172 chr20:30296095 A/C cg21427119 chr20:30132790 HM13 -0.35 -7.9 -0.3 1.18e-14 Mean corpuscular hemoglobin; BRCA cis rs7412746 0.634 rs2124952 chr1:150923774 T/A cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.22e-14 Melanoma; BRCA cis rs10464366 0.912 rs7785889 chr7:39106368 G/T cg15212455 chr7:39170539 POU6F2 0.39 8.31 0.31 5.54e-16 IgG glycosylation; BRCA cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 7.94 0.3 9.05e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3784262 0.904 rs3784260 chr15:58253269 T/G cg12031962 chr15:58353849 ALDH1A2 -0.44 -11.8 -0.42 3.28e-29 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg26384229 chr12:38710491 ALG10B 0.64 14.93 0.51 1.8e-43 Bladder cancer; BRCA cis rs8022179 0.566 rs62006258 chr14:103838909 A/C cg12935359 chr14:103987150 CKB 0.45 8.59 0.32 6.69e-17 Monocyte count; BRCA cis rs6815814 0.950 rs5743563 chr4:38806019 A/G cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.08e-15 Alzheimer's disease (late onset); BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg21724239 chr8:58056113 NA 0.59 9.5 0.35 4.25e-20 Developmental language disorder (linguistic errors); BRCA cis rs12760731 0.565 rs7541122 chr1:178199214 G/C cg00404053 chr1:178313656 RASAL2 0.64 7.9 0.3 1.2e-14 Obesity-related traits; BRCA cis rs1577917 0.771 rs7762321 chr6:86412146 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 13.56 0.47 5.41e-37 Response to antipsychotic treatment; BRCA cis rs57221529 0.713 rs72703072 chr5:590626 A/G cg09021430 chr5:549028 NA -0.65 -13.67 -0.48 1.7e-37 Lung disease severity in cystic fibrosis; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg22920501 chr2:26401640 FAM59B 0.94 16.22 0.54 8.59e-50 Gut microbiome composition (summer); BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg00166722 chr3:10149974 C3orf24 0.63 11.14 0.4 1.77e-26 Alzheimer's disease; BRCA cis rs7590720 0.840 rs705648 chr2:216933792 C/T cg12620499 chr2:216877984 MREG 0.71 17.4 0.57 8.81e-56 Alcohol dependence; BRCA cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg11644478 chr21:40555479 PSMG1 0.85 19.32 0.61 7.99e-66 Cognitive function; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg10729496 chr3:10149963 C3orf24 0.47 7.83 0.3 2.04e-14 Alzheimer's disease; BRCA cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.47 0.47 1.43e-36 Mean platelet volume; BRCA cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg13010199 chr12:38710504 ALG10B 0.44 9.01 0.34 2.44e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg24642439 chr20:33292090 TP53INP2 -0.44 -9.12 -0.34 1e-18 Glomerular filtration rate (creatinine); BRCA cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg06784218 chr1:46089804 CCDC17 0.51 12.23 0.44 4.9e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg03452623 chr4:187889614 NA -0.31 -10.11 -0.37 2.26e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs7582180 0.715 rs7571306 chr2:100906084 G/C cg14675211 chr2:100938903 LONRF2 0.38 8.34 0.31 4.63e-16 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -11.1 -0.4 2.77e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12541635 0.934 rs1353450 chr8:107035120 A/G cg10147462 chr8:107024639 NA -0.38 -10.43 -0.38 1.28e-23 Age of smoking initiation; BRCA cis rs897080 0.552 rs1085442 chr2:44635454 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.89 0.33 6.35e-18 Height; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg09177884 chr7:1199841 ZFAND2A -0.51 -10.89 -0.4 1.96e-25 Longevity;Endometriosis; BRCA cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg23711669 chr6:146136114 FBXO30 0.72 16.15 0.54 1.91e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg19346786 chr7:2764209 NA -0.3 -9.43 -0.35 7.72e-20 Height; BRCA cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.79 -20.02 -0.62 1.4e-69 Systemic lupus erythematosus; BRCA cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11890956 chr21:40555474 PSMG1 -0.82 -19.6 -0.61 2.48e-67 Cognitive function; BRCA cis rs10503871 0.625 rs13275869 chr8:30310335 T/C cg26383811 chr8:30366931 RBPMS 0.31 8.17 0.31 1.66e-15 Metabolite levels (X-11787); BRCA cis rs317689 0.718 rs160827 chr12:69770147 G/A cg20891283 chr12:69753455 YEATS4 0.56 11.31 0.41 3.83e-27 Response to diuretic therapy; BRCA cis rs6138458 1.000 rs4273288 chr20:24900873 G/A cg06937882 chr20:24974362 C20orf3 0.44 8.38 0.31 3.34e-16 Blood protein levels; BRCA cis rs8180040 0.966 rs56351005 chr3:47430186 G/T cg27129171 chr3:47204927 SETD2 -0.69 -16.29 -0.54 3.8e-50 Colorectal cancer; BRCA cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg14582100 chr15:45693742 SPATA5L1 0.35 11.34 0.41 2.68e-27 Homoarginine levels; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg03188948 chr7:1209495 NA 0.84 11.6 0.42 2.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35995292 0.500 rs1019065 chr7:38939775 C/T cg19327137 chr7:38886074 VPS41 0.39 12.81 0.45 1.3e-33 Subjective well-being (multi-trait analysis); BRCA cis rs7772486 0.624 rs9485018 chr6:146025731 T/C cg23711669 chr6:146136114 FBXO30 -0.71 -17.03 -0.56 6.36e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs2762353 0.639 rs566530 chr6:25878361 T/C cg03517284 chr6:25882590 NA -0.45 -10.37 -0.38 2.07e-23 Blood metabolite levels; BRCA trans rs1493916 0.905 rs4799727 chr18:31393095 T/G cg27147174 chr7:100797783 AP1S1 -0.56 -10.86 -0.39 2.57e-25 Life satisfaction; BRCA cis rs3771570 1.000 rs62193256 chr2:242362168 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.27 0.34 2.73e-19 Prostate cancer; BRCA cis rs727479 0.543 rs6493488 chr15:51513922 G/C cg19946085 chr15:51559439 CYP19A1 -0.3 -8.3 -0.31 5.99e-16 Estradiol levels; BRCA cis rs758324 0.947 rs1500114 chr5:131138120 C/A cg06307176 chr5:131281290 NA 0.53 10.27 0.38 5.48e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs4074536 0.796 rs10801990 chr1:116309183 G/A cg21648376 chr1:116311395 CASQ2 -0.5 -8.79 -0.33 1.36e-17 QRS duration; BRCA cis rs858239 0.539 rs2141306 chr7:23191664 G/A cg23682824 chr7:23144976 KLHL7 0.41 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg14951292 chr16:4525986 HMOX2;NMRAL1 0.41 8.62 0.32 5.44e-17 Schizophrenia; BRCA cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg14019146 chr3:50243930 SLC38A3 0.37 9.02 0.34 2.15e-18 Menarche (age at onset); BRCA cis rs425277 1.000 rs262670 chr1:2082458 C/T cg24578937 chr1:2090814 PRKCZ 0.58 17.85 0.58 3.97e-58 Height; BRCA cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg06238570 chr21:40685208 BRWD1 0.41 8.36 0.31 3.97e-16 Cognitive function; BRCA cis rs815815 0.608 rs815808 chr2:47381097 C/T cg27223769 chr2:47403360 CALM2 0.44 9.7 0.36 7.58e-21 Dialysis-related mortality; BRCA cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs67981189 0.896 rs17108804 chr14:71441524 A/G cg15816911 chr14:71606274 NA -0.36 -8.14 -0.31 2.09e-15 Schizophrenia; BRCA cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg24562669 chr7:97807699 LMTK2 0.45 12.14 0.43 1.12e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7147624 1.000 rs2411354 chr14:66062132 T/C cg03016385 chr14:66212404 NA -0.57 -8.58 -0.32 7.08e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg09184832 chr6:79620586 NA -0.53 -11.72 -0.42 7.38e-29 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg26597838 chr10:835615 NA 1.3 21.91 0.65 8.86e-80 Eosinophil percentage of granulocytes; BRCA cis rs2625529 1.000 rs2625529 chr15:72118777 C/G cg16672083 chr15:72433130 SENP8 0.67 14.42 0.5 5.4e-41 Red blood cell count; BRCA trans rs7824557 0.736 rs35392635 chr8:11164349 G/C cg06636001 chr8:8085503 FLJ10661 0.54 10.13 0.37 1.79e-22 Retinal vascular caliber; BRCA cis rs4595586 0.545 rs3858553 chr12:39381291 A/C cg26384229 chr12:38710491 ALG10B 0.55 11.69 0.42 9.73e-29 Morning vs. evening chronotype; BRCA cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg23583168 chr7:148888333 NA -0.79 -18.42 -0.59 4.27e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg02951883 chr7:2050386 MAD1L1 -0.6 -14.79 -0.5 8.99e-43 Bipolar disorder and schizophrenia; BRCA cis rs875971 0.830 rs427575 chr7:65519219 A/G cg18876405 chr7:65276391 NA 0.58 13.82 0.48 3.53e-38 Aortic root size; BRCA cis rs870825 0.616 rs4437295 chr4:185643336 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg07917127 chr4:99064746 C4orf37 0.43 8.0 0.3 5.74e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg00166722 chr3:10149974 C3orf24 0.64 11.21 0.41 9.9e-27 Alzheimer's disease; BRCA cis rs7246967 0.673 rs4932782 chr19:22812801 A/G cg23217946 chr19:22817039 ZNF492 0.47 8.43 0.32 2.22e-16 Bronchopulmonary dysplasia; BRCA cis rs11098499 0.908 rs7696649 chr4:120322177 G/A cg09307838 chr4:120376055 NA 0.72 15.35 0.52 1.79e-45 Corneal astigmatism; BRCA cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg24112000 chr20:60950667 NA -0.54 -10.49 -0.38 7.11e-24 Colorectal cancer; BRCA cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg10523679 chr1:76189770 ACADM -0.48 -9.37 -0.35 1.2e-19 Daytime sleep phenotypes; BRCA trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.53 16.34 0.54 2.16e-50 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs2806561 0.704 rs856510 chr1:23524407 A/C cg12483005 chr1:23474871 LUZP1 0.48 10.46 0.38 9.57e-24 Height; BRCA cis rs7727544 0.716 rs4594848 chr5:131586598 C/A cg14196790 chr5:131705035 SLC22A5 0.44 11.23 0.41 7.91e-27 Blood metabolite levels; BRCA cis rs9818758 0.607 rs13068038 chr3:49294250 C/A cg01304814 chr3:48885189 PRKAR2A 0.62 7.84 0.3 1.9e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -11.59 -0.42 2.63e-28 Glomerular filtration rate (creatinine); BRCA cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 7.17e-41 Motion sickness; BRCA cis rs9815354 0.812 rs17214945 chr3:41808660 A/C cg03022575 chr3:42003672 ULK4 0.71 9.78 0.36 3.77e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.19 0.46 2.76e-35 Electroencephalogram traits; BRCA cis rs13053817 1.000 rs73405097 chr22:29855836 T/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.48 -9.24 -0.34 3.69e-19 Carotid atherosclerosis in HIV infection; BRCA cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg06108461 chr20:60628389 TAF4 -0.83 -18.02 -0.58 5.48e-59 Body mass index; BRCA cis rs9287719 0.967 rs10167129 chr2:10758575 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.16 -0.31 1.79e-15 Prostate cancer; BRCA cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.27e-15 Developmental language disorder (linguistic errors); BRCA cis rs312273 0.774 rs10879421 chr12:41350775 T/A cg17827154 chr12:41323612 CNTN1 -0.42 -11.08 -0.4 3.3e-26 Bipolar disorder; BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg18404041 chr3:52824283 ITIH1 -0.28 -8.15 -0.31 1.95e-15 Electroencephalogram traits; BRCA cis rs17270561 0.609 rs9366629 chr6:25741216 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.33 12.21 0.44 5.52e-31 Autism spectrum disorder or schizophrenia; BRCA trans rs6076960 0.629 rs6054024 chr20:6229282 A/C cg21095983 chr6:86352623 SYNCRIP 0.42 9.28 0.34 2.53e-19 Smooth-surface caries; BRCA cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg23029597 chr12:123009494 RSRC2 -0.54 -11.27 -0.41 5.32e-27 Body mass index; BRCA cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg12935359 chr14:103987150 CKB -0.59 -13.89 -0.48 1.67e-38 Body mass index; BRCA cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg24110177 chr3:50126178 RBM5 0.41 11.23 0.41 8.18e-27 Intelligence (multi-trait analysis); BRCA cis rs425277 0.917 rs262656 chr1:2088754 A/C cg00981070 chr1:2046702 PRKCZ 0.31 8.16 0.31 1.75e-15 Height; BRCA cis rs4888262 0.545 rs4243108 chr16:74692453 A/G cg01733217 chr16:74700730 RFWD3 -0.77 -19.49 -0.61 9.95e-67 Testicular germ cell tumor; BRCA cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg05623727 chr3:50126028 RBM5 0.48 11.82 0.42 2.58e-29 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -10.63 -0.39 2.01e-24 Myopia (pathological); BRCA cis rs8180040 0.966 rs922957 chr3:47422152 G/C cg16586182 chr3:47516702 SCAP 0.65 15.07 0.51 3.86e-44 Colorectal cancer; BRCA cis rs9858542 0.953 rs6997 chr3:49453834 C/T cg03060546 chr3:49711283 APEH -0.51 -10.27 -0.38 5.2e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg27661571 chr11:113659931 NA -0.8 -12.01 -0.43 4.07e-30 Hip circumference adjusted for BMI; BRCA cis rs13082711 0.834 rs2172297 chr3:27428423 C/T cg02860705 chr3:27208620 NA 0.54 10.23 0.38 7.78e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2797160 1.000 rs1739362 chr6:126020703 A/T cg05901451 chr6:126070800 HEY2 0.39 9.44 0.35 7.03e-20 Endometrial cancer; BRCA cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.14 0.4 1.78e-26 Schizophrenia; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.19 -0.34 5.55e-19 Total body bone mineral density; BRCA cis rs17253792 0.822 rs77315200 chr14:56072643 C/A cg01858014 chr14:56050164 KTN1 -0.76 -10.52 -0.38 5.5e-24 Putamen volume; BRCA cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg06159980 chr1:16340746 HSPB7 -0.37 -7.87 -0.3 1.53e-14 Dilated cardiomyopathy; BRCA cis rs36051895 0.632 rs57698263 chr9:5143262 G/A cg02405213 chr9:5042618 JAK2 -0.45 -8.65 -0.32 4.04e-17 Pediatric autoimmune diseases; BRCA cis rs2070488 0.965 rs2284820 chr3:38562579 C/T cg24069376 chr3:38537580 EXOG -0.42 -12.16 -0.43 9.9e-31 Electrocardiographic conduction measures; BRCA cis rs4718428 0.662 rs34577323 chr7:66310041 G/C cg18252515 chr7:66147081 NA -0.55 -11.18 -0.4 1.24e-26 Corneal structure; BRCA cis rs10746514 0.833 rs2356925 chr1:232261769 G/A cg09506761 chr1:232265262 NA -0.42 -8.54 -0.32 9.77e-17 Response to statin therapy; BRCA cis rs208520 0.690 rs6932475 chr6:66863155 G/A cg07460842 chr6:66804631 NA -1.02 -20.08 -0.62 6.71e-70 Exhaled nitric oxide output; BRCA cis rs701145 0.585 rs1727919 chr3:153788757 G/A cg17054900 chr3:154042577 DHX36 0.53 9.19 0.34 5.62e-19 Coronary artery disease; BRCA trans rs79976124 0.837 rs10944858 chr6:66646039 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.76 0.39 6.29e-25 Type 2 diabetes; BRCA cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 29.81 0.76 4.96e-123 Chronic sinus infection; BRCA cis rs3862030 0.720 rs11593526 chr10:104228017 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.11 -0.43 1.53e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg13319975 chr6:146136371 FBXO30 0.35 8.09 0.3 3.08e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg24812749 chr6:127587940 RNF146 0.86 19.78 0.62 2.55e-68 Breast cancer; BRCA trans rs877282 1.000 rs7100358 chr10:773681 G/A cg22713356 chr15:30763199 NA 1.17 23.7 0.68 1.43e-89 Uric acid levels; BRCA cis rs7927592 0.913 rs11228292 chr11:68379772 C/T cg20283391 chr11:68216788 NA -0.45 -8.98 -0.33 3.1e-18 Total body bone mineral density; BRCA cis rs10090774 0.710 rs11166992 chr8:141677470 C/T cg18440839 chr8:141609380 EIF2C2 -0.25 -8.29 -0.31 6.6e-16 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg24642844 chr7:1081250 C7orf50 -0.79 -14.76 -0.5 1.17e-42 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2304069 1.000 rs216126 chr5:149428424 G/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.57 12.06 0.43 2.64e-30 HIV-1 control; BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg04546413 chr19:29218101 NA 0.64 12.33 0.44 1.75e-31 Methadone dose in opioid dependence; BRCA cis rs71636778 0.584 rs17162316 chr1:27177907 C/G cg12203394 chr1:27248618 NUDC 0.5 7.92 0.3 1.06e-14 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg21475434 chr5:93447410 FAM172A 0.66 9.02 0.34 2.24e-18 Diabetic retinopathy; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.37 -7.85 -0.3 1.76e-14 Longevity;Endometriosis; BRCA cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.48e-66 Mean platelet volume; BRCA cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg13256891 chr4:100009986 ADH5 0.53 9.87 0.36 1.75e-21 Smoking initiation; BRCA cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs868036 0.915 rs4489954 chr15:68072075 A/C cg05925327 chr15:68127851 NA 0.34 8.34 0.31 4.45e-16 Restless legs syndrome; BRCA cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs6088813 0.922 rs6088800 chr20:33934437 T/A cg14752227 chr20:34000481 UQCC -0.39 -8.43 -0.32 2.34e-16 Height; BRCA cis rs3768617 0.510 rs10752895 chr1:183068505 C/G ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA cis rs514406 0.760 rs475969 chr1:53292607 T/A cg01802117 chr1:53393560 SCP2 -0.35 -8.03 -0.3 4.71e-15 Monocyte count; BRCA cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg06212747 chr3:49208901 KLHDC8B 0.41 7.84 0.3 1.9e-14 Menarche (age at onset); BRCA cis rs1865760 0.541 rs1436309 chr6:25970109 T/A cg16482183 chr6:26056742 HIST1H1C 0.53 10.94 0.4 1.18e-25 Height; BRCA cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg19257562 chr1:2043853 PRKCZ -0.32 -8.83 -0.33 9.99e-18 Height; BRCA cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.25e-55 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.641 rs2387810 chr12:38368875 G/T cg06521331 chr12:34319734 NA -0.46 -8.44 -0.32 2.08e-16 Bladder cancer; BRCA cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg16339924 chr4:17578868 LAP3 -0.56 -13.35 -0.47 4.83e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.66e-15 Menopause (age at onset); BRCA cis rs1568889 0.838 rs6484359 chr11:28262328 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.59 0.63 1.17e-72 Bipolar disorder; BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -8.24 -0.31 9.84e-16 Developmental language disorder (linguistic errors); BRCA cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg23625390 chr15:77176239 SCAPER 0.39 9.61 0.36 1.62e-20 Blood metabolite levels; BRCA cis rs7772486 0.686 rs9390349 chr6:146054430 T/G cg23711669 chr6:146136114 FBXO30 -0.71 -16.78 -0.55 1.24e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs6430585 0.702 rs2304601 chr2:136528034 C/A cg07169764 chr2:136633963 MCM6 1.23 26.49 0.72 6.67e-105 Corneal structure; BRCA cis rs3820928 0.874 rs4675134 chr2:227843489 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.21 -0.31 1.19e-15 Pulmonary function; BRCA cis rs11874712 0.965 rs28694780 chr18:43665338 C/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg22920501 chr2:26401640 FAM59B -0.81 -13.19 -0.46 2.66e-35 Gut microbiome composition (summer); BRCA cis rs11098499 0.865 rs2389809 chr4:120377399 T/C cg09307838 chr4:120376055 NA 0.76 17.1 0.56 2.9e-54 Corneal astigmatism; BRCA cis rs394563 0.601 rs439495 chr6:149793224 A/G cg07828024 chr6:149772892 ZC3H12D 0.3 8.46 0.32 1.83e-16 Dupuytren's disease; BRCA cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg07606381 chr6:8435919 SLC35B3 -0.64 -14.12 -0.49 1.31e-39 Motion sickness; BRCA cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg24558204 chr6:135376177 HBS1L -0.47 -12.99 -0.46 2.15e-34 High light scatter reticulocyte percentage of red cells; BRCA cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg11764359 chr7:65958608 NA 0.65 11.55 0.42 3.6e-28 Aortic root size; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg09177884 chr7:1199841 ZFAND2A -0.61 -15.19 -0.51 1.07e-44 Longevity;Endometriosis; BRCA cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.51 -0.32 1.19e-16 Monocyte percentage of white cells; BRCA trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.29 -0.34 2.45e-19 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.510 rs6666259 chr1:183102855 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.55 0.57 1.5e-56 Fuchs's corneal dystrophy; BRCA cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.3 0.41 3.86e-27 Electroencephalogram traits; BRCA cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg17892150 chr10:133769511 PPP2R2D -0.73 -15.66 -0.53 4.96e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs11098499 0.575 rs907205 chr4:120238664 G/C cg09307838 chr4:120376055 NA 0.64 13.91 0.48 1.32e-38 Corneal astigmatism; BRCA cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg10253484 chr15:75165896 SCAMP2 -0.51 -9.84 -0.36 2.38e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg27446573 chr6:127587934 RNF146 0.9 21.24 0.64 3.9e-76 Breast cancer; BRCA cis rs4975616 0.807 rs28379291 chr5:1313701 A/G cg07493874 chr5:1342172 CLPTM1L 0.45 12.15 0.43 1.09e-30 Lung cancer; BRCA cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg11301795 chr4:187892539 NA -0.31 -9.97 -0.37 7.56e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13126279 chr21:47581558 C21orf56 -0.45 -9.9 -0.36 1.4e-21 Testicular germ cell tumor; BRCA trans rs877282 0.898 rs11253343 chr10:765117 C/T cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg22467129 chr15:76604101 ETFA -0.41 -9.14 -0.34 8.13e-19 Blood metabolite levels; BRCA cis rs4862750 0.872 rs4862748 chr4:187877388 C/T cg10295955 chr4:187884368 NA 0.73 18.09 0.58 2.35e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg12751644 chr20:60527061 NA -0.33 -7.95 -0.3 8.44e-15 Body mass index; BRCA cis rs17253792 0.822 rs17683728 chr14:56060389 C/T cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs312274 0.508 rs11178858 chr12:41267529 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -8.8 -0.33 1.3e-17 Metabolite levels (X-11787); BRCA cis rs6570726 0.935 rs386344 chr6:145855622 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.09 0.51 2.99e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs11711311 1.000 rs10934243 chr3:113430239 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.89 -0.36 1.49e-21 IgG glycosylation; BRCA cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg22307297 chr20:60903441 LAMA5 0.34 9.35 0.35 1.47e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs4588572 0.601 rs10070202 chr5:77792462 A/C cg11547950 chr5:77652471 NA -0.5 -8.95 -0.33 3.93e-18 Triglycerides; BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg08280861 chr8:58055591 NA 0.54 8.82 0.33 1.12e-17 Developmental language disorder (linguistic errors); BRCA cis rs4409675 0.576 rs7520860 chr1:28232952 C/A cg23691781 chr1:28212827 C1orf38 0.33 10.95 0.4 1.06e-25 Corneal astigmatism; BRCA cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg20503657 chr10:835505 NA 1.3 21.68 0.65 1.61e-78 Eosinophil percentage of granulocytes; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg18402987 chr7:1209562 NA 0.82 11.83 0.42 2.38e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.63 -0.32 4.88e-17 Glomerular filtration rate (creatinine); BRCA cis rs8028182 0.636 rs4545784 chr15:75755651 A/G cg20655648 chr15:75932815 IMP3 0.41 8.01 0.3 5.5e-15 Sudden cardiac arrest; BRCA cis rs332507 0.830 rs10804562 chr3:124377196 C/T cg05980111 chr3:124395277 KALRN 0.34 8.14 0.31 2.09e-15 Plateletcrit; BRCA cis rs8062405 0.755 rs56209193 chr16:28585636 C/T cg16576597 chr16:28551801 NUPR1 0.33 8.83 0.33 9.92e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs754466 0.580 rs2289309 chr10:79571108 C/T cg17075019 chr10:79541650 NA -0.86 -23.42 -0.68 4.49e-88 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg18357526 chr6:26021779 HIST1H4A 0.51 9.48 0.35 4.78e-20 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg25801113 chr15:45476975 SHF 0.31 7.83 0.3 2e-14 Uric acid levels; BRCA cis rs514406 0.505 rs437954 chr1:53173321 C/G cg08859206 chr1:53392774 SCP2 -0.42 -8.46 -0.32 1.85e-16 Monocyte count; BRCA cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg10932868 chr11:921992 NA 0.35 8.03 0.3 4.74e-15 Alzheimer's disease (late onset); BRCA trans rs57046232 0.552 rs6038449 chr20:6337980 C/T cg21095983 chr6:86352623 SYNCRIP 0.38 8.06 0.3 3.86e-15 Colorectal cancer; BRCA cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12292205 chr6:26970375 C6orf41 -0.49 -8.3 -0.31 6.14e-16 Intelligence (multi-trait analysis); BRCA cis rs997295 0.520 rs4776971 chr15:68081097 C/A cg08079166 chr15:68083412 MAP2K5 0.31 8.29 0.31 6.61e-16 Motion sickness; BRCA cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg22972055 chr7:872293 UNC84A 0.38 8.34 0.31 4.73e-16 Cerebrospinal P-tau181p levels; BRCA trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.96e-15 Corneal astigmatism; BRCA cis rs36051895 0.664 rs3780374 chr9:5099677 G/A cg02405213 chr9:5042618 JAK2 -0.48 -8.59 -0.32 6.75e-17 Pediatric autoimmune diseases; BRCA cis rs1215050 0.740 rs700740 chr4:98976003 A/C cg05340658 chr4:99064831 C4orf37 -0.48 -10.94 -0.4 1.22e-25 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg11266682 chr4:10021025 SLC2A9 0.49 13.19 0.46 2.72e-35 Bone mineral density; BRCA cis rs6543140 0.964 rs13383602 chr2:103085962 C/T cg04239558 chr2:103089729 SLC9A4 0.35 9.9 0.36 1.39e-21 Blood protein levels; BRCA trans rs9858542 0.953 rs9814873 chr3:49454112 A/G cg21659725 chr3:3221576 CRBN -0.46 -9.92 -0.37 1.15e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs921968 0.541 rs4674314 chr2:219423520 A/G cg02176678 chr2:219576539 TTLL4 -0.48 -12.13 -0.43 1.3e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7824557 0.767 rs11775635 chr8:11164865 G/A cg21775007 chr8:11205619 TDH 0.61 11.78 0.42 3.94e-29 Retinal vascular caliber; BRCA trans rs79976124 0.800 rs12194767 chr6:66639599 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.58 10.33 0.38 3.1e-23 Type 2 diabetes; BRCA cis rs10789491 0.953 rs11211337 chr1:47133811 T/C cg15501359 chr1:47185051 KIAA0494 0.66 18.07 0.58 2.88e-59 Response to hepatitis C treatment; BRCA cis rs9287719 0.934 rs6432111 chr2:10744620 A/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg27170947 chr2:26402098 FAM59B -0.95 -16.91 -0.56 2.58e-53 Gut microbiome composition (summer); BRCA cis rs7781557 1.000 rs11496066 chr7:102486254 T/C cg18108683 chr7:102477205 FBXL13 -0.43 -7.81 -0.3 2.44e-14 Colorectal adenoma (advanced); BRCA cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs6867032 0.958 rs4975797 chr5:2015573 G/A cg26168224 chr5:2018326 NA 0.63 17.47 0.57 3.54e-56 Gut microbiome composition (winter); BRCA cis rs1003719 0.586 rs2298685 chr21:38533390 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.54 -0.5 1.43e-41 Eye color traits; BRCA cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg22467129 chr15:76604101 ETFA 0.53 12.41 0.44 7.84e-32 Blood metabolite levels; BRCA cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg00071950 chr4:10020882 SLC2A9 0.64 16.0 0.53 1.06e-48 Bone mineral density; BRCA cis rs4595586 0.505 rs11613808 chr12:39390823 T/A cg26384229 chr12:38710491 ALG10B 0.56 11.64 0.42 1.58e-28 Morning vs. evening chronotype; BRCA cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg04267008 chr7:1944627 MAD1L1 -0.38 -8.34 -0.31 4.53e-16 Schizophrenia; BRCA cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg11266682 chr4:10021025 SLC2A9 0.48 12.5 0.44 3.17e-32 Bone mineral density; BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg14004847 chr7:1930337 MAD1L1 -0.41 -8.41 -0.32 2.67e-16 Schizophrenia; BRCA trans rs11098499 0.863 rs3775848 chr4:120447724 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.45 0.44 5.14e-32 Corneal astigmatism; BRCA cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg07817648 chr10:79422355 NA -0.66 -12.38 -0.44 1.09e-31 Bone mineral density; BRCA cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg03425785 chr20:62221387 GMEB2 0.51 8.27 0.31 7.88e-16 Glioblastoma; BRCA cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg04267008 chr7:1944627 MAD1L1 -0.55 -10.97 -0.4 8.66e-26 Bipolar disorder and schizophrenia; BRCA cis rs3960554 0.673 rs112680895 chr7:75623520 G/A cg17325771 chr7:75508891 RHBDD2 -0.32 -7.87 -0.3 1.48e-14 Eotaxin levels; BRCA cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg19539972 chr4:7069911 GRPEL1 0.7 17.16 0.56 1.42e-54 Monocyte percentage of white cells; BRCA cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.51 -0.47 9.34e-37 Developmental language disorder (linguistic errors); BRCA cis rs5769707 0.609 rs739247 chr22:49996657 T/C cg05373962 chr22:49881684 NA -0.31 -8.5 -0.32 1.38e-16 Monocyte count;Monocyte percentage of white cells; BRCA cis rs775227 0.574 rs55693215 chr3:113064094 T/C cg18753928 chr3:113234510 CCDC52 -0.58 -9.44 -0.35 6.65e-20 Dental caries; BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg02951883 chr7:2050386 MAD1L1 -0.55 -12.43 -0.44 6.65e-32 Bipolar disorder and schizophrenia; BRCA cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg01448562 chr3:133502909 NA -0.65 -15.37 -0.52 1.4e-45 Iron status biomarkers; BRCA cis rs9420 0.528 rs73480556 chr11:57400462 G/C cg19752551 chr11:57585705 CTNND1 -0.38 -9.61 -0.36 1.69e-20 Schizophrenia; BRCA cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg23033748 chr14:75592666 NEK9 -0.44 -10.37 -0.38 2.06e-23 Height; BRCA cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.49 8.65 0.32 4e-17 Multiple sclerosis; BRCA cis rs6456156 0.586 rs2017338 chr6:167471714 G/A cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs701145 0.938 rs355769 chr3:154042550 T/C cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg05234568 chr11:5960015 NA -0.47 -9.75 -0.36 4.86e-21 DNA methylation (variation); BRCA cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg19678392 chr7:94953810 PON1 -0.41 -8.77 -0.33 1.66e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.64 -0.36 1.32e-20 Mean corpuscular volume; BRCA cis rs17401966 0.838 rs12125535 chr1:10350849 T/A cg03954927 chr1:10346856 KIF1B 0.44 13.78 0.48 5.15e-38 Hepatocellular carcinoma; BRCA cis rs832540 0.629 rs3309 chr5:56092779 A/T cg12311346 chr5:56204834 C5orf35 0.41 8.4 0.32 2.82e-16 Coronary artery disease; BRCA cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg24642439 chr20:33292090 TP53INP2 0.47 10.44 0.38 1.19e-23 Glomerular filtration rate (creatinine); BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg02951883 chr7:2050386 MAD1L1 -0.6 -15.49 -0.52 3.48e-46 Bipolar disorder and schizophrenia; BRCA cis rs4285028 0.747 rs3732410 chr3:121415720 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.84 -16.36 -0.54 1.66e-50 Multiple sclerosis; BRCA cis rs12618769 0.597 rs3754891 chr2:99088018 T/C cg10123293 chr2:99228465 UNC50 0.41 8.52 0.32 1.14e-16 Bipolar disorder; BRCA cis rs7582180 0.614 rs4851309 chr2:100975390 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.47 0.41 8.1e-28 Intelligence (multi-trait analysis); BRCA cis rs752010 0.808 rs7529858 chr1:42086606 G/C cg06885757 chr1:42089581 HIVEP3 0.3 10.72 0.39 8.97e-25 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7085104 0.700 rs743572 chr10:104597152 A/G cg04362960 chr10:104952993 NT5C2 0.4 9.64 0.36 1.23e-20 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 16.39 0.54 1.2e-50 Allergic disease (asthma, hay fever or eczema); BRCA cis rs61931739 0.534 rs11053073 chr12:34202412 C/T cg06521331 chr12:34319734 NA -0.65 -11.93 -0.43 9.53e-30 Morning vs. evening chronotype; BRCA trans rs4596713 0.568 rs7038833 chr9:71748097 C/T cg16512924 chr15:28394682 HERC2 0.4 9.65 0.36 1.13e-20 Headache; BRCA cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg03808351 chr9:123631620 PHF19 -0.6 -12.8 -0.45 1.48e-33 Birth weight; BRCA cis rs10752881 1.000 rs10752883 chr1:182980963 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.53e-53 Colorectal cancer; BRCA cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg06115741 chr20:33292138 TP53INP2 -0.4 -8.8 -0.33 1.25e-17 Glomerular filtration rate (creatinine); BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.11 0.43 1.58e-30 Tonsillectomy; BRCA cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg03452623 chr4:187889614 NA -0.35 -11.63 -0.42 1.71e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs2339496 chr1:152970719 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.85 -0.36 2.13e-21 Inflammatory skin disease; BRCA cis rs1882538 0.569 rs11562036 chr7:133076862 T/C cg10665199 chr7:133106180 EXOC4 0.44 9.21 0.34 4.69e-19 Intelligence (multi-trait analysis); BRCA cis rs2354432 0.607 rs6703847 chr1:146669444 G/A cg25205988 chr1:146714368 CHD1L 0.86 10.6 0.39 2.66e-24 Mitochondrial DNA levels; BRCA cis rs11971779 0.941 rs28395455 chr7:139035986 A/G cg07862535 chr7:139043722 LUC7L2 0.4 9.56 0.35 2.41e-20 Diisocyanate-induced asthma; BRCA cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg17971929 chr21:40555470 PSMG1 -0.47 -10.26 -0.38 5.66e-23 Menarche (age at onset); BRCA cis rs2070488 0.804 rs6764551 chr3:38460305 A/G cg24069376 chr3:38537580 EXOG 0.31 8.69 0.32 3.12e-17 Electrocardiographic conduction measures; BRCA cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg19418458 chr7:158789849 NA -0.41 -9.07 -0.34 1.46e-18 Facial morphology (factor 20); BRCA cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg23649088 chr2:200775458 C2orf69 -0.62 -10.36 -0.38 2.39e-23 Schizophrenia; BRCA cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg04450456 chr4:17643702 FAM184B 0.32 9.36 0.35 1.33e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs1941687 0.563 rs2032189 chr18:31332200 T/A cg27147174 chr7:100797783 AP1S1 -0.44 -8.6 -0.32 6.24e-17 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.22 -0.37 8.01e-23 Schizophrenia; BRCA cis rs752010 0.806 rs1109255 chr1:42091708 C/T cg06885757 chr1:42089581 HIVEP3 0.28 10.15 0.37 1.57e-22 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg16230307 chr14:35515116 FAM177A1 0.75 15.43 0.52 6.65e-46 Psoriasis; BRCA cis rs10193935 0.901 rs871045 chr2:42609431 G/C cg27598129 chr2:42591480 NA -0.84 -14.07 -0.49 2.42e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 4.09e-29 Bipolar disorder; BRCA cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg21951975 chr1:209979733 IRF6 0.4 9.3 0.35 2.28e-19 Cleft lip with or without cleft palate; BRCA cis rs2836974 0.897 rs2776308 chr21:40715175 A/G cg11890956 chr21:40555474 PSMG1 0.94 23.2 0.68 7.77e-87 Cognitive function; BRCA cis rs965469 0.947 rs6051692 chr20:3244098 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -10.54 -0.38 4.7e-24 IFN-related cytopenia; BRCA cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg24562669 chr7:97807699 LMTK2 0.63 18.75 0.6 7.64e-63 Breast cancer; BRCA cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -20.03 -0.62 1.28e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.28e-18 Tonsillectomy; BRCA cis rs11997175 0.766 rs4273817 chr8:33702686 C/T ch.8.33884649F chr8:33765107 NA 0.35 8.32 0.31 5.3e-16 Body mass index; BRCA cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg26031613 chr14:104095156 KLC1 0.75 16.48 0.55 4.1e-51 Body mass index; BRCA cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg12463550 chr7:65579703 CRCP -0.37 -7.95 -0.3 8.25e-15 Aortic root size; BRCA cis rs2795502 1.000 rs2795502 chr10:43340662 G/A cg20628663 chr10:43360327 NA -0.71 -13.64 -0.47 2.25e-37 Blood protein levels; BRCA cis rs7520050 0.807 rs4274104 chr1:46217941 T/C cg24296786 chr1:45957014 TESK2 -0.47 -10.67 -0.39 1.44e-24 Red blood cell count;Reticulocyte count; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg14789911 chr21:47582049 C21orf56 0.38 7.98 0.3 6.75e-15 Testicular germ cell tumor; BRCA cis rs3820928 0.967 rs4675118 chr2:227773157 C/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.45 -0.32 1.9e-16 Pulmonary function; BRCA trans rs1459104 1.000 rs12788969 chr11:55253357 G/T cg15704280 chr7:45808275 SEPT13 0.65 8.15 0.31 1.85e-15 Body mass index; BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00166722 chr3:10149974 C3orf24 0.56 10.98 0.4 7.86e-26 Alzheimer's disease; BRCA cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.57 8.93 0.33 4.48e-18 Lung function (FEV1/FVC); BRCA cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg10792982 chr14:105748885 BRF1 0.5 11.4 0.41 1.55e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.84 0.55 5.87e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg12373951 chr3:133503437 NA 0.53 12.58 0.45 1.41e-32 Iron status biomarkers; BRCA cis rs1577917 0.958 rs12197463 chr6:86445242 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.69 -0.45 4.41e-33 Response to antipsychotic treatment; BRCA cis rs4363385 0.818 rs57311099 chr1:153005597 A/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24110177 chr3:50126178 RBM5 -0.36 -9.59 -0.35 1.96e-20 Intelligence (multi-trait analysis); BRCA cis rs295140 0.605 rs10931893 chr2:201114652 A/G cg23649088 chr2:200775458 C2orf69 -0.39 -8.15 -0.31 1.93e-15 QT interval; BRCA cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.53e-23 Motion sickness; BRCA cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.13 0.37 1.85e-22 Bladder cancer; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg04166393 chr7:2884313 GNA12 0.46 8.72 0.33 2.42e-17 Height; BRCA cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg12927641 chr6:109611667 NA -0.36 -8.96 -0.33 3.66e-18 Reticulocyte fraction of red cells; BRCA cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.14 -0.31 2.06e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs12681288 0.550 rs59004371 chr8:962393 T/C cg04851639 chr8:1020857 NA -0.32 -8.82 -0.33 1.05e-17 Schizophrenia; BRCA cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg00958927 chr1:175162553 KIAA0040 0.21 7.92 0.3 1.03e-14 Alcohol dependence; BRCA cis rs7829975 0.577 rs940030 chr8:8546928 A/G cg15556689 chr8:8085844 FLJ10661 -0.35 -9.03 -0.34 1.97e-18 Mood instability; BRCA cis rs1568889 0.938 rs7128045 chr11:28190180 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.76 0.5 1.17e-42 Bipolar disorder; BRCA cis rs910316 0.763 rs735452 chr14:75497984 A/G cg08847533 chr14:75593920 NEK9 -0.88 -21.91 -0.65 8.97e-80 Height; BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 21.71 0.65 1.08e-78 Platelet count; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg25036284 chr2:26402008 FAM59B 0.88 15.16 0.51 1.48e-44 Gut microbiome composition (summer); BRCA cis rs4363385 0.791 rs489323 chr1:153006047 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs2404602 0.552 rs11072613 chr15:76961526 A/C cg23625390 chr15:77176239 SCAPER -0.52 -11.15 -0.4 1.71e-26 Blood metabolite levels; BRCA cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg10664184 chr19:17420304 DDA1 -0.36 -10.11 -0.37 2.24e-22 Systemic lupus erythematosus; BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -9.04 -0.34 1.88e-18 Tonsillectomy; BRCA cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg23029597 chr12:123009494 RSRC2 -0.61 -11.79 -0.42 3.46e-29 Body mass index; BRCA cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg01448562 chr3:133502909 NA -0.59 -14.23 -0.49 4.11e-40 Iron status biomarkers; BRCA cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg23090583 chr17:61904693 PSMC5;FTSJ3 -0.45 -11.1 -0.4 2.76e-26 Height; BRCA cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg16405210 chr4:1374714 KIAA1530 -0.43 -9.67 -0.36 9.69e-21 Longevity; BRCA cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg12310025 chr6:25882481 NA -0.5 -12.06 -0.43 2.52e-30 Blood metabolite levels; BRCA cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg00745463 chr17:30367425 LRRC37B -0.61 -9.57 -0.35 2.21e-20 Hip circumference adjusted for BMI; BRCA cis rs1448094 0.511 rs11117042 chr12:86207547 G/T cg19622623 chr12:86230825 RASSF9 -0.33 -8.84 -0.33 9.37e-18 Major depressive disorder; BRCA cis rs11626933 0.851 rs2282031 chr14:90730943 A/G cg04374321 chr14:90722782 PSMC1 0.43 9.26 0.34 3.06e-19 Gut microbiota (bacterial taxa); BRCA cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 13.92 0.48 1.2e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs1538970 0.781 rs34768551 chr1:46020408 G/A cg05343316 chr1:45956843 TESK2 0.69 13.83 0.48 3.08e-38 Platelet count; BRCA cis rs3925075 0.553 rs3087796 chr16:31343653 A/G cg02846316 chr16:31340340 ITGAM 0.43 8.73 0.33 2.22e-17 IgA nephropathy; BRCA cis rs9287719 0.967 rs2110778 chr2:10748970 A/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs113835537 0.529 rs75685325 chr11:66235242 A/G cg24851651 chr11:66362959 CCS 0.51 8.79 0.33 1.32e-17 Airway imaging phenotypes; BRCA cis rs34779708 0.966 rs4934730 chr10:35415555 A/G cg03585969 chr10:35415529 CREM 0.55 11.37 0.41 2.17e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg04586622 chr2:25135609 ADCY3 0.46 11.61 0.42 2.11e-28 Body mass index; BRCA cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg23173402 chr1:227635558 NA 0.5 9.12 0.34 9.47e-19 Major depressive disorder; BRCA cis rs2204008 0.594 rs11531211 chr12:37998007 T/G cg13010199 chr12:38710504 ALG10B -0.4 -8.58 -0.32 6.91e-17 Bladder cancer; BRCA cis rs41005 0.967 rs41006 chr2:8109348 A/G cg03155496 chr2:8117019 LOC339788 0.56 14.96 0.51 1.26e-43 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs7208859 0.623 rs122898 chr17:28905254 C/T cg13385521 chr17:29058706 SUZ12P -0.67 -9.39 -0.35 1.05e-19 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg08514558 chr10:81106712 PPIF 0.35 8.42 0.32 2.43e-16 Height; BRCA cis rs6594499 0.872 rs10043631 chr5:110443228 C/T cg04022379 chr5:110408740 TSLP 0.35 8.1 0.31 2.81e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6987853 0.787 rs2923437 chr8:42425399 A/C cg09913449 chr8:42400586 C8orf40 0.4 8.89 0.33 6.02e-18 Mean corpuscular hemoglobin concentration; BRCA cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg15605315 chr1:45957053 TESK2 0.5 9.99 0.37 6.14e-22 High light scatter reticulocyte count; BRCA cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg27129171 chr3:47204927 SETD2 0.73 17.76 0.57 1.15e-57 Colorectal cancer; BRCA cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg12311346 chr5:56204834 C5orf35 -0.46 -9.15 -0.34 7.58e-19 Coronary artery disease; BRCA cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg07138768 chr7:917805 C7orf20 0.28 8.09 0.3 3.09e-15 Perceived unattractiveness to mosquitoes; BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.14 0.34 8.16e-19 Alzheimer's disease; BRCA trans rs4332037 0.510 rs58673065 chr7:1885600 A/G cg11693508 chr17:37793320 STARD3 0.48 10.28 0.38 4.99e-23 Bipolar disorder; BRCA cis rs13082711 0.863 rs34611823 chr3:27500344 A/G cg02860705 chr3:27208620 NA 0.53 10.58 0.39 3.1e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.12 -0.31 2.44e-15 Bipolar disorder; BRCA cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg06618935 chr21:46677482 NA -0.38 -8.6 -0.32 6.24e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg06484146 chr7:12443880 VWDE -0.75 -10.68 -0.39 1.29e-24 Coronary artery disease; BRCA cis rs250677 0.522 rs2895837 chr5:148357535 C/T cg18129178 chr5:148520854 ABLIM3 0.54 10.4 0.38 1.58e-23 Breast cancer; BRCA cis rs9462027 0.628 rs2814961 chr6:34706951 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA trans rs9291683 0.588 rs3796829 chr4:10019138 C/G cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.34e-16 Bone mineral density; BRCA cis rs1198872 0.526 rs57282335 chr2:10928207 G/A cg15705551 chr2:10952987 PDIA6 0.53 9.52 0.35 3.45e-20 Cardiac Troponin-T levels; BRCA cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg11266682 chr4:10021025 SLC2A9 0.4 10.5 0.38 6.54e-24 Bone mineral density; BRCA cis rs7789940 0.809 rs12533836 chr7:75935622 G/T cg10167463 chr7:75959203 YWHAG -0.42 -8.33 -0.31 5.07e-16 Multiple sclerosis; BRCA cis rs897080 0.552 rs1067405 chr2:44674861 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.62 0.36 1.5e-20 Height; BRCA cis rs2580764 0.565 rs2919129 chr2:55216545 G/T cg09592903 chr2:55203963 RTN4 0.39 9.93 0.37 1.02e-21 Mean platelet volume; BRCA cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg12219531 chr12:120966889 COQ5 0.53 11.53 0.41 4.63e-28 High light scatter reticulocyte count; BRCA cis rs2645424 0.530 rs1293303 chr8:11720227 C/G cg21281001 chr8:11725306 CTSB -0.39 -8.04 -0.3 4.52e-15 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); BRCA cis rs782590 0.935 rs2627776 chr2:55873301 T/A cg18811423 chr2:55921094 PNPT1 0.74 24.19 0.69 2.83e-92 Metabolic syndrome; BRCA cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg17971929 chr21:40555470 PSMG1 0.6 13.68 0.48 1.55e-37 Cognitive function; BRCA cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.28 -0.31 7.1e-16 Bipolar disorder; BRCA cis rs9463078 0.845 rs6458419 chr6:45085038 T/C cg25276700 chr6:44698697 NA -0.36 -8.19 -0.31 1.38e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9290065 0.686 rs1839021 chr3:160623669 T/G cg03342759 chr3:160939853 NMD3 0.43 8.67 0.32 3.42e-17 Kawasaki disease; BRCA cis rs870825 0.616 rs7692104 chr4:185650895 T/G cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs2880765 0.566 rs12911430 chr15:86011264 A/T cg19183879 chr15:85880815 NA -0.32 -7.89 -0.3 1.29e-14 Coronary artery disease; BRCA cis rs17253792 0.822 rs78988988 chr14:56152404 G/A cg01858014 chr14:56050164 KTN1 -0.76 -9.53 -0.35 3.34e-20 Putamen volume; BRCA cis rs11190604 1.000 rs17746014 chr10:102315354 T/C cg07080220 chr10:102295463 HIF1AN 0.64 14.77 0.5 1.06e-42 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9308731 0.644 rs3789068 chr2:111909247 A/G cg04780086 chr2:111875790 ACOXL 0.27 7.81 0.3 2.44e-14 Chronic lymphocytic leukemia; BRCA cis rs12367572 0.796 rs7979141 chr12:45282630 A/T cg04608330 chr12:45269318 NELL2 -0.62 -13.68 -0.48 1.43e-37 Gut microbiome composition (summer); BRCA cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg25208724 chr1:156163844 SLC25A44 1.07 35.1 0.81 3.35e-151 Testicular germ cell tumor; BRCA cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -7.98 -0.3 6.99e-15 Extrinsic epigenetic age acceleration; BRCA cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg14582100 chr15:45693742 SPATA5L1 0.29 8.61 0.32 5.82e-17 Homoarginine levels; BRCA cis rs9859260 0.710 rs34906439 chr3:195779706 A/G cg12923728 chr3:195709715 SDHAP1 0.38 7.92 0.3 1.09e-14 Mean corpuscular volume; BRCA trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21659725 chr3:3221576 CRBN 0.47 11.96 0.43 6.65e-30 Intelligence (multi-trait analysis); BRCA cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg20019365 chr2:219134978 PNKD;AAMP 0.6 13.8 0.48 4.39e-38 Colorectal cancer; BRCA cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg05973401 chr12:123451056 ABCB9 0.42 9.25 0.34 3.25e-19 Platelet count; BRCA cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg20476274 chr7:133979776 SLC35B4 0.7 21.47 0.65 2.12e-77 Mean platelet volume; BRCA cis rs12760731 0.720 rs3791023 chr1:178398092 A/C cg00404053 chr1:178313656 RASAL2 0.6 7.86 0.3 1.58e-14 Obesity-related traits; BRCA cis rs736408 0.507 rs6445531 chr3:52717282 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.36 -0.35 1.33e-19 Bipolar disorder; BRCA cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg08975724 chr8:8085496 FLJ10661 0.5 11.01 0.4 6.27e-26 Mood instability; BRCA cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg03433033 chr1:76189801 ACADM 0.76 17.06 0.56 4.94e-54 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg17330251 chr7:94953956 PON1 -0.42 -8.87 -0.33 7.37e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2637266 1.000 rs2395388 chr10:78357203 C/T cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg13114125 chr14:105738426 BRF1 -0.53 -11.02 -0.4 5.39e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 9.02 0.34 2.13e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs629535 0.862 rs2178955 chr8:70045303 C/T cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg09184832 chr6:79620586 NA -0.41 -8.24 -0.31 1.01e-15 Intelligence (multi-trait analysis); BRCA cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg20818283 chr2:191399100 TMEM194B 0.38 8.87 0.33 7.24e-18 Pulse pressure; BRCA cis rs9549260 0.755 rs2721066 chr13:41156188 C/T cg21288729 chr13:41239152 FOXO1 -0.67 -14.93 -0.51 1.81e-43 Red blood cell count; BRCA cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg27129171 chr3:47204927 SETD2 -0.7 -16.91 -0.56 2.66e-53 Colorectal cancer; BRCA cis rs7666738 0.791 rs1527516 chr4:98967937 A/C cg05340658 chr4:99064831 C4orf37 0.67 16.75 0.55 1.82e-52 Colonoscopy-negative controls vs population controls; BRCA trans rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.98 -0.3 6.56e-15 Endometrial cancer; BRCA cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 10.3 0.38 4.03e-23 Aortic root size; BRCA cis rs6032067 0.673 rs4522674 chr20:43893276 T/C cg06407657 chr20:43937138 MATN4;RBPJL 0.3 8.13 0.31 2.3e-15 Blood protein levels; BRCA cis rs7617773 0.780 rs13066044 chr3:48377276 C/T cg11946769 chr3:48343235 NME6 0.67 13.48 0.47 1.23e-36 Coronary artery disease; BRCA cis rs654950 0.901 rs1885654 chr1:42007188 C/A cg06885757 chr1:42089581 HIVEP3 -0.33 -10.88 -0.4 1.98e-25 Airway imaging phenotypes; BRCA cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.17e-27 High light scatter reticulocyte count; BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24549020 chr5:56110836 MAP3K1 0.63 12.79 0.45 1.71e-33 Initial pursuit acceleration; BRCA cis rs11043280 0.703 rs11043275 chr12:122402723 T/C cg13699009 chr12:122356056 WDR66 0.35 7.99 0.3 6.12e-15 Mean platelet volume; BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg13047869 chr3:10149882 C3orf24 0.53 9.72 0.36 6.19e-21 Alzheimer's disease; BRCA cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg08219700 chr8:58056026 NA 0.58 9.7 0.36 7.56e-21 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11890956 chr21:40555474 PSMG1 0.83 13.8 0.48 3.98e-38 Cognitive function; BRCA cis rs7959452 0.535 rs7308481 chr12:69659299 A/G cg20891283 chr12:69753455 YEATS4 0.56 14.26 0.49 2.96e-40 Blood protein levels; BRCA cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.02 0.4 5.84e-26 Monocyte percentage of white cells; BRCA cis rs3820928 0.935 rs113195824 chr2:227769139 A/G cg05526886 chr2:227700861 RHBDD1 -0.38 -7.83 -0.3 2.03e-14 Pulmonary function; BRCA cis rs4363385 0.747 rs1055935 chr1:152975941 C/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.24 -0.31 1.01e-15 Inflammatory skin disease; BRCA cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.58 12.24 0.44 4.16e-31 Lymphocyte percentage of white cells; BRCA cis rs826838 1.000 rs826891 chr12:39100824 A/G cg13010199 chr12:38710504 ALG10B -0.42 -9.78 -0.36 3.79e-21 Heart rate; BRCA cis rs11792861 0.816 rs744980 chr9:111690388 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.97 0.3 7.54e-15 Menarche (age at onset); BRCA cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.54 -10.17 -0.37 1.24e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7647973 0.710 rs11130207 chr3:49611666 T/G cg07636037 chr3:49044803 WDR6 0.55 8.7 0.33 2.75e-17 Menarche (age at onset); BRCA cis rs1476670 0.710 rs753637 chr1:44508927 A/G cg09470012 chr1:44509516 NA 0.45 9.49 0.35 4.33e-20 Eotaxin levels; BRCA cis rs698833 0.509 rs6715202 chr2:44516282 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.34 0.31 4.66e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13012494 chr21:47604986 C21orf56 0.44 8.92 0.33 5.06e-18 Testicular germ cell tumor; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg22920501 chr2:26401640 FAM59B 0.94 16.38 0.54 1.37e-50 Gut microbiome composition (summer); BRCA cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg07636037 chr3:49044803 WDR6 0.98 28.62 0.75 1.36e-116 Parkinson's disease; BRCA cis rs11098499 0.618 rs6858383 chr4:120296772 T/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs3857067 0.806 rs12505596 chr4:95109600 A/G cg11021082 chr4:95130006 SMARCAD1 -0.41 -9.35 -0.35 1.5e-19 QT interval; BRCA cis rs10181042 0.514 rs1177288 chr2:61352985 A/G cg15711740 chr2:61764176 XPO1 -0.37 -8.6 -0.32 6e-17 Crohn's disease; BRCA cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg01579765 chr21:45077557 HSF2BP -0.39 -10.61 -0.39 2.52e-24 Mean corpuscular volume; BRCA cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg11632617 chr15:75315747 PPCDC -0.35 -7.98 -0.3 6.9e-15 Blood trace element (Zn levels); BRCA cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg04990556 chr1:26633338 UBXN11 -0.47 -9.3 -0.35 2.25e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg04025307 chr7:1156635 C7orf50 0.58 9.0 0.34 2.5e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.690 rs34818745 chr4:120257055 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.86 0.3 1.64e-14 Corneal astigmatism; BRCA cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg27129171 chr3:47204927 SETD2 0.67 15.63 0.53 7.35e-47 Colorectal cancer; BRCA cis rs561341 0.769 rs559228 chr17:30294527 T/C cg12193833 chr17:30244370 NA -0.54 -8.66 -0.32 3.95e-17 Hip circumference adjusted for BMI; BRCA trans rs9467711 0.659 rs72845428 chr6:26550144 C/T cg01620082 chr3:125678407 NA -0.69 -8.52 -0.32 1.12e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs312274 0.674 rs11178540 chr12:41213695 T/C cg17827154 chr12:41323612 CNTN1 0.36 8.84 0.33 8.92e-18 Metabolite levels (X-11787); BRCA cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg07423050 chr13:99094983 FARP1 -0.63 -16.07 -0.54 4.67e-49 Neuroticism; BRCA cis rs67072384 0.818 rs12287481 chr11:72472336 A/C cg04827223 chr11:72435913 ARAP1 0.56 9.38 0.35 1.13e-19 Alloimmunization response to red blood cell transfusion in sickle cell anemia; BRCA cis rs4268898 0.636 rs72787383 chr2:24583861 G/A cg06627628 chr2:24431161 ITSN2 -0.84 -15.52 -0.52 2.6e-46 Asthma; BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg24642844 chr7:1081250 C7orf50 -0.58 -11.88 -0.43 1.53e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs11971779 0.680 rs7779900 chr7:139082987 G/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs4363385 0.818 rs653332 chr1:153010481 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.62 -0.32 5.39e-17 Inflammatory skin disease; BRCA cis rs1994135 0.654 rs1384591 chr12:33734170 T/C cg06521331 chr12:34319734 NA -0.44 -8.18 -0.31 1.54e-15 Resting heart rate; BRCA cis rs7586879 0.929 rs6545808 chr2:25124388 C/A cg04586622 chr2:25135609 ADCY3 0.4 9.23 0.34 3.91e-19 Body mass index; BRCA cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg27129171 chr3:47204927 SETD2 0.67 15.64 0.53 6.56e-47 Colorectal cancer; BRCA cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg00750074 chr16:89608354 SPG7 -0.39 -10.48 -0.38 7.9e-24 Multiple myeloma (IgH translocation); BRCA trans rs4714291 0.832 rs9471244 chr6:40092331 A/G cg02267698 chr19:7991119 CTXN1 0.44 9.23 0.34 3.92e-19 Strep throat; BRCA cis rs6005807 0.668 rs9620808 chr22:28993331 A/C cg12565055 chr22:29076175 TTC28 0.5 9.38 0.35 1.17e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.35 -0.31 4.32e-16 Colorectal cancer; BRCA cis rs490234 0.841 rs497531 chr9:128314664 C/T cg14078157 chr9:128172775 NA 0.34 8.07 0.3 3.42e-15 Mean arterial pressure; BRCA cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs2742234 0.590 rs741968 chr10:43611708 A/G cg15436174 chr10:43711423 RASGEF1A -0.54 -10.84 -0.39 2.99e-25 Hirschsprung disease; BRCA cis rs9399135 0.967 rs1854865 chr6:135360300 C/G cg24558204 chr6:135376177 HBS1L 0.44 12.22 0.44 5.38e-31 Red blood cell count; BRCA cis rs10992471 0.528 rs3739606 chr9:95237222 G/T cg14631576 chr9:95140430 CENPP -0.34 -8.69 -0.33 3.01e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs2425143 1.000 rs11700256 chr20:34372941 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.17 -0.34 6.32e-19 Blood protein levels; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg04025307 chr7:1156635 C7orf50 0.62 14.72 0.5 2.01e-42 Longevity;Endometriosis; BRCA trans rs11098499 0.562 rs2389879 chr4:120557684 G/A cg25214090 chr10:38739885 LOC399744 -0.4 -9.14 -0.34 8.21e-19 Corneal astigmatism; BRCA cis rs9649465 0.967 rs12538876 chr7:123296320 C/A cg04330084 chr7:123175371 IQUB -0.32 -8.87 -0.33 7.15e-18 Migraine; BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg17986701 chr20:44574422 PCIF1 -0.4 -9.35 -0.35 1.41e-19 Intelligence (multi-trait analysis); BRCA cis rs3008870 1.000 rs1925412 chr1:67405057 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.98 0.66 3.63e-80 Lymphocyte percentage of white cells; BRCA cis rs9814567 1.000 rs9851441 chr3:134315091 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.23 -0.61 2.35e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11229555 0.645 rs12283414 chr11:58176920 C/T cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.91 -0.3 1.16e-14 Axial length; BRCA cis rs13095912 1.000 rs1823238 chr3:185341970 G/A cg11274856 chr3:185301563 NA 0.35 8.84 0.33 9.08e-18 Systolic blood pressure; BRCA cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg14019146 chr3:50243930 SLC38A3 -0.43 -10.37 -0.38 2.13e-23 Body mass index; BRCA cis rs2880765 0.835 rs4360875 chr15:86040394 A/G cg10818794 chr15:86012489 AKAP13 -0.29 -8.19 -0.31 1.37e-15 Coronary artery disease; BRCA cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg06453172 chr10:134556979 INPP5A -0.47 -11.06 -0.4 4e-26 Migraine; BRCA cis rs6700896 0.931 rs11809906 chr1:66115064 C/T cg04111102 chr1:66153794 NA 0.34 8.42 0.32 2.57e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg23711669 chr6:146136114 FBXO30 0.78 18.68 0.59 1.85e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs8028182 0.636 rs8030802 chr15:75813153 A/G cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs7246657 0.943 rs8109038 chr19:38015709 A/G cg18154014 chr19:37997991 ZNF793 -0.62 -12.13 -0.43 1.31e-30 Coronary artery calcification; BRCA cis rs6547741 0.935 rs12714204 chr2:27787540 T/C cg27432699 chr2:27873401 GPN1 0.49 10.25 0.38 6.18e-23 Oral cavity cancer; BRCA cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg08917208 chr2:24149416 ATAD2B 0.9 12.95 0.46 3.2e-34 Lymphocyte counts; BRCA cis rs17270561 0.636 rs6923839 chr6:25745853 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.18e-17 Iron status biomarkers; BRCA cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg17143192 chr8:8559678 CLDN23 -0.58 -11.81 -0.42 3.01e-29 Obesity-related traits; BRCA cis rs6542838 0.641 rs10192266 chr2:99521837 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -9.59 -0.35 1.94e-20 Fear of minor pain; BRCA cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg03146154 chr1:46216737 IPP -0.44 -9.72 -0.36 6.67e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg24812749 chr6:127587940 RNF146 0.66 14.91 0.51 2.21e-43 Breast cancer; BRCA cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg02659138 chr7:134003124 SLC35B4 0.35 10.85 0.39 2.84e-25 Mean platelet volume; BRCA cis rs1863824 0.625 rs7091192 chr10:88167456 A/G cg07322936 chr10:88137208 NA -0.45 -8.87 -0.33 7.29e-18 Schizophrenia; BRCA cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg08601574 chr20:25228251 PYGB 0.34 8.07 0.3 3.54e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg00677455 chr12:58241039 CTDSP2 0.63 14.33 0.49 1.39e-40 Multiple sclerosis; BRCA cis rs12101261 0.560 rs1035144 chr14:81445121 C/T cg06600135 chr14:81408086 NA 0.34 8.33 0.31 4.94e-16 Graves' disease; BRCA cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg06618935 chr21:46677482 NA -0.36 -8.0 -0.3 5.85e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1341267 0.529 rs6492721 chr13:95258944 A/G cg18412871 chr13:95254051 GPR180 -0.37 -9.0 -0.34 2.54e-18 Triglyceride levels; BRCA trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg03929089 chr4:120376271 NA 0.65 12.61 0.45 1.01e-32 Coronary artery disease; BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg16606324 chr3:10149918 C3orf24 0.5 10.02 0.37 4.84e-22 Alzheimer's disease; BRCA cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg13256891 chr4:100009986 ADH5 0.5 9.53 0.35 3.08e-20 Alcohol dependence; BRCA cis rs12711979 0.509 rs13005405 chr2:3826324 C/T cg17052675 chr2:3827356 NA -0.69 -23.52 -0.68 1.37e-88 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg03709012 chr19:19516395 GATAD2A 0.73 16.16 0.54 1.74e-49 Tonsillectomy; BRCA cis rs936229 0.861 rs11634474 chr15:75116184 C/G cg14664628 chr15:75095509 CSK -0.95 -29.41 -0.76 6.68e-121 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6495367 1.000 rs13380109 chr15:79378775 G/A cg17916960 chr15:79447300 NA 0.32 8.1 0.31 2.85e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg05234568 chr11:5960015 NA -0.44 -9.26 -0.34 2.98e-19 DNA methylation (variation); BRCA cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg23711669 chr6:146136114 FBXO30 0.77 17.98 0.58 8.97e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.92e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10876993 0.890 rs115106209 chr12:58059331 G/A cg18357645 chr12:58087776 OS9 0.46 13.48 0.47 1.26e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs1865760 0.519 rs2275904 chr6:25768085 T/C cg17691542 chr6:26056736 HIST1H1C 0.57 10.98 0.4 7.99e-26 Height; BRCA cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.57 11.35 0.41 2.54e-27 Monocyte percentage of white cells; BRCA cis rs561341 1.000 rs473356 chr17:30321762 G/C cg23018236 chr17:30244563 NA -0.64 -10.28 -0.38 4.62e-23 Hip circumference adjusted for BMI; BRCA cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.22 0.37 8.24e-23 Bladder cancer; BRCA cis rs6570726 0.846 rs439035 chr6:145887990 G/C cg23711669 chr6:146136114 FBXO30 0.72 17.41 0.57 7.59e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.582 rs6982832 chr8:8792217 A/C cg15556689 chr8:8085844 FLJ10661 -0.43 -11.89 -0.43 1.31e-29 Mood instability; BRCA cis rs2832077 0.943 rs2832106 chr21:30191767 A/G cg08807101 chr21:30365312 RNF160 -0.46 -7.93 -0.3 9.9e-15 Cognitive test performance; BRCA cis rs9790314 0.521 rs2122527 chr3:161091636 G/A cg03342759 chr3:160939853 NMD3 -0.56 -12.15 -0.43 1.01e-30 Morning vs. evening chronotype; BRCA cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.43 -0.32 2.26e-16 Monocyte percentage of white cells; BRCA cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.49 0.32 1.42e-16 Menopause (age at onset); BRCA cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.55 -0.42 3.82e-28 Uric acid levels; BRCA cis rs897080 0.552 rs1067374 chr2:44650250 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.48 -8.83 -0.33 9.84e-18 Height; BRCA trans rs629535 0.814 rs62513373 chr8:70080753 C/T cg21567404 chr3:27674614 NA -1.01 -21.8 -0.65 3.47e-79 Dupuytren's disease; BRCA trans rs7824557 0.606 rs2736273 chr8:11199938 C/A cg15556689 chr8:8085844 FLJ10661 0.34 9.37 0.35 1.25e-19 Retinal vascular caliber; BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg08132940 chr7:1081526 C7orf50 -0.61 -9.05 -0.34 1.74e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17253792 0.822 rs28392709 chr14:56093685 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA trans rs9291683 0.509 rs10939671 chr4:10050815 T/C cg26043149 chr18:55253948 FECH 0.39 8.46 0.32 1.78e-16 Bone mineral density; BRCA cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg18876405 chr7:65276391 NA 0.45 8.72 0.33 2.46e-17 Corneal structure; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg09177884 chr7:1199841 ZFAND2A -0.52 -11.38 -0.41 1.82e-27 Longevity;Endometriosis; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg04025307 chr7:1156635 C7orf50 0.6 15.26 0.52 4.76e-45 Longevity;Endometriosis; BRCA cis rs9790314 0.540 rs35462273 chr3:160991877 C/T cg17135325 chr3:160939158 NMD3 0.41 7.91 0.3 1.11e-14 Morning vs. evening chronotype; BRCA cis rs3784262 0.607 rs4646576 chr15:58338998 A/T cg12031962 chr15:58353849 ALDH1A2 -0.54 -13.8 -0.48 4.4e-38 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6598955 0.627 rs12143920 chr1:26575834 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs16958440 0.867 rs80006910 chr18:44696382 C/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg12573674 chr2:1569213 NA -0.48 -9.25 -0.34 3.41e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg11584989 chr19:19387371 SF4 0.64 12.57 0.45 1.49e-32 Bipolar disorder; BRCA cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24110177 chr3:50126178 RBM5 -0.37 -9.86 -0.36 1.89e-21 Intelligence (multi-trait analysis); BRCA cis rs1499972 0.941 rs73183041 chr3:117610500 C/A cg07612923 chr3:117604196 NA 0.59 7.91 0.3 1.11e-14 Schizophrenia; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg03354898 chr7:1950403 MAD1L1 -0.4 -8.34 -0.31 4.42e-16 Bipolar disorder and schizophrenia; BRCA cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg08999081 chr20:33150536 PIGU 0.47 12.97 0.46 2.57e-34 Glomerular filtration rate (creatinine); BRCA cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.21 -0.43 5.77e-31 Tonsillectomy; BRCA cis rs2415984 0.622 rs1761027 chr14:46929611 G/A cg14871534 chr14:47121158 RPL10L 0.33 8.1 0.31 2.77e-15 Number of children ever born; BRCA cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.43 0.59 3.92e-61 Cognitive function; BRCA cis rs4660306 1.000 rs10736426 chr1:45984353 A/G cg24296786 chr1:45957014 TESK2 -0.44 -9.32 -0.35 1.84e-19 Homocysteine levels; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg04025307 chr7:1156635 C7orf50 0.57 13.38 0.47 3.7e-36 Longevity;Endometriosis; BRCA cis rs9287719 0.967 rs2110776 chr2:10748810 A/G cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs4481887 0.927 rs10157089 chr1:248488157 A/G cg13385794 chr1:248469461 NA 0.27 7.89 0.3 1.32e-14 Common traits (Other); BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg08470875 chr2:26401718 FAM59B -0.5 -8.11 -0.31 2.69e-15 Gut microbiome composition (summer); BRCA cis rs11190604 1.000 rs3750627 chr10:102275642 G/T cg07080220 chr10:102295463 HIF1AN 0.61 14.49 0.5 2.37e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6815814 0.950 rs73236615 chr4:38786869 G/T cg02016764 chr4:38805732 TLR1 -0.54 -8.84 -0.33 9.38e-18 Breast cancer; BRCA cis rs3799379 0.530 rs10456045 chr6:26404958 A/G cg12826209 chr6:26865740 GUSBL1 -0.44 -8.03 -0.3 4.68e-15 Intelligence (multi-trait analysis); BRCA cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg11764359 chr7:65958608 NA -0.62 -13.69 -0.48 1.34e-37 Aortic root size; BRCA trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg16141378 chr3:129829833 LOC729375 -0.34 -7.88 -0.3 1.41e-14 Neuroticism; BRCA cis rs9287719 0.967 rs4405729 chr2:10755779 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs6840360 0.615 rs2406973 chr4:152608339 G/T cg22705602 chr4:152727874 NA 0.36 9.95 0.37 8.71e-22 Intelligence (multi-trait analysis); BRCA cis rs1577917 0.740 rs2475792 chr6:86392102 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 13.29 0.47 9.28e-36 Response to antipsychotic treatment; BRCA cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg06558623 chr16:89946397 TCF25 0.65 11.89 0.43 1.36e-29 Skin colour saturation; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs1348850 0.526 rs6723063 chr2:178491398 C/T cg27490568 chr2:178487706 NA 0.59 10.28 0.38 4.95e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.3 0.38 4.03e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs72772090 0.522 rs75553638 chr5:95992460 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -8.42 -0.32 2.4e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg17971929 chr21:40555470 PSMG1 0.79 18.87 0.6 1.9e-63 Cognitive function; BRCA cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.58 9.12 0.34 9.64e-19 Lung function (FEV1/FVC); BRCA trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.89 -0.56 3.51e-53 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg06618935 chr21:46677482 NA -0.35 -8.01 -0.3 5.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs751728 0.605 rs1535950 chr6:33785827 A/G cg15252951 chr6:33757062 LEMD2 0.36 8.65 0.32 4.29e-17 Crohn's disease; BRCA cis rs561341 1.000 rs555629 chr17:30294136 T/C cg12193833 chr17:30244370 NA -0.54 -8.66 -0.32 3.95e-17 Hip circumference adjusted for BMI; BRCA cis rs8180040 0.934 rs4858811 chr3:47480524 G/C cg27129171 chr3:47204927 SETD2 -0.68 -15.69 -0.53 3.44e-47 Colorectal cancer; BRCA cis rs7917772 0.502 rs2296584 chr10:104244323 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.76 0.62 3.43e-68 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg05340658 chr4:99064831 C4orf37 0.68 16.86 0.55 5.15e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg25237894 chr2:233734115 C2orf82 -0.4 -11.34 -0.41 2.66e-27 Coronary artery disease; BRCA trans rs11976180 1.000 rs2371248 chr7:143764189 C/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg11764359 chr7:65958608 NA 0.65 11.88 0.43 1.52e-29 Aortic root size; BRCA trans rs11098499 0.865 rs4507344 chr4:120307485 C/A cg25214090 chr10:38739885 LOC399744 0.51 11.54 0.42 4.01e-28 Corneal astigmatism; BRCA cis rs2742417 0.603 rs9826208 chr3:45773991 C/T cg04837898 chr3:45731254 SACM1L -0.38 -7.82 -0.3 2.24e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg25237894 chr2:233734115 C2orf82 -0.38 -11.09 -0.4 2.95e-26 Coronary artery disease; BRCA cis rs10883723 0.737 rs11191312 chr10:104278601 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 16.64 0.55 6.55e-52 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg23711669 chr6:146136114 FBXO30 0.83 20.04 0.62 1.16e-69 Lobe attachment (rater-scored or self-reported); BRCA cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg20362242 chr5:692897 TPPP 0.56 8.74 0.33 2.03e-17 Lung disease severity in cystic fibrosis; BRCA cis rs701145 0.585 rs9839821 chr3:153796323 G/A cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg11279151 chr3:101281821 RG9MTD1 0.35 8.06 0.3 3.77e-15 Colorectal cancer; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4280164 0.945 rs3181384 chr14:24786976 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.45 -7.87 -0.3 1.49e-14 Parent of origin effect on language impairment (paternal); BRCA cis rs3125734 0.633 rs10740068 chr10:63982254 A/C cg09941381 chr10:64027924 RTKN2 -0.29 -8.73 -0.33 2.29e-17 Rheumatoid arthritis; BRCA cis rs2635047 0.967 rs9960264 chr18:44606996 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 7.92 0.3 1.05e-14 Educational attainment; BRCA cis rs9486719 0.857 rs6568392 chr6:96861476 G/T cg06623918 chr6:96969491 KIAA0776 0.76 16.01 0.54 8.84e-49 Migraine;Coronary artery disease; BRCA cis rs473651 0.935 rs508483 chr2:239339709 T/C cg03560586 chr2:239334908 ASB1 -0.5 -11.2 -0.41 9.95e-27 Multiple system atrophy; BRCA cis rs1595825 0.891 rs75946628 chr2:198546239 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -7.97 -0.3 7.09e-15 Ulcerative colitis; BRCA cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg11271282 chr2:238384023 NA 0.43 8.21 0.31 1.2e-15 Prostate cancer; BRCA cis rs1505368 0.567 rs972491 chr2:213316573 A/G cg16329650 chr2:213403929 ERBB4 -0.39 -9.45 -0.35 6.16e-20 Symmetrical dimethylarginine levels; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg14004847 chr7:1930337 MAD1L1 -0.42 -8.08 -0.3 3.16e-15 Bipolar disorder and schizophrenia; BRCA cis rs77106637 1.000 rs11605166 chr11:72669777 T/C cg03713592 chr11:72463424 ARAP1 0.77 11.59 0.42 2.41e-28 Type 2 diabetes; BRCA cis rs4478858 0.684 rs7544946 chr1:31749736 T/C cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg10729496 chr3:10149963 C3orf24 0.41 7.85 0.3 1.75e-14 Alzheimer's disease; BRCA cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg06238570 chr21:40685208 BRWD1 -0.41 -8.21 -0.31 1.26e-15 Menarche (age at onset); BRCA cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg24829409 chr8:58192753 C8orf71 -0.59 -12.3 -0.44 2.45e-31 Developmental language disorder (linguistic errors); BRCA cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg26373071 chr5:1325741 CLPTM1L 0.5 12.32 0.44 1.92e-31 Lung cancer; BRCA cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg11644478 chr21:40555479 PSMG1 0.85 19.43 0.61 2.08e-66 Cognitive function; BRCA cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg18850127 chr7:39170497 POU6F2 0.55 11.95 0.43 7.19e-30 IgG glycosylation; BRCA cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg20848291 chr7:100343083 ZAN -0.51 -11.56 -0.42 3.37e-28 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1348850 0.526 rs7607073 chr2:178375065 C/A cg27490568 chr2:178487706 NA 0.51 8.58 0.32 7.29e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs6570726 0.791 rs4332001 chr6:145934841 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.04 0.56 6.19e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg11645453 chr3:52864694 ITIH4 -0.46 -11.38 -0.41 1.86e-27 Schizophrenia; BRCA trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21659725 chr3:3221576 CRBN -0.45 -11.4 -0.41 1.54e-27 Intelligence (multi-trait analysis); BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.58 -0.52 1.25e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7607369 0.536 rs13032993 chr2:219666377 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -10.11 -0.37 2.09e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.62 0.42 1.93e-28 Homoarginine levels; BRCA cis rs6964587 0.967 rs6980247 chr7:91594228 T/A cg17063962 chr7:91808500 NA 0.57 13.54 0.47 6.61e-37 Breast cancer; BRCA cis rs2380220 0.576 rs4498363 chr6:96042338 A/C cg15832292 chr6:96025679 MANEA 0.55 8.32 0.31 5.14e-16 Behavioural disinhibition (generation interaction); BRCA cis rs1042058 0.565 rs2480297 chr10:30754512 A/G cg18806716 chr10:30721971 MAP3K8 -0.42 -10.05 -0.37 3.58e-22 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs17401966 0.558 rs17402762 chr1:10414470 T/C cg03954927 chr1:10346856 KIF1B 0.34 10.2 0.37 1.02e-22 Hepatocellular carcinoma; BRCA cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.48 11.06 0.4 3.96e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg13010199 chr12:38710504 ALG10B 0.45 9.34 0.35 1.53e-19 Bladder cancer; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg12419862 chr22:24373484 LOC391322 0.86 21.98 0.66 3.4e-80 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg11764359 chr7:65958608 NA -0.65 -14.24 -0.49 3.73e-40 Aortic root size; BRCA trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg17830980 chr10:43048298 ZNF37B 0.56 13.91 0.48 1.31e-38 Extrinsic epigenetic age acceleration; BRCA cis rs12973672 0.855 rs7256866 chr19:35771257 A/G cg12095397 chr19:35769544 USF2 0.37 8.33 0.31 5.05e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs12618769 0.597 rs17505326 chr2:99156807 T/A cg10123293 chr2:99228465 UNC50 0.43 8.32 0.31 5.53e-16 Bipolar disorder; BRCA cis rs9457247 0.602 rs6456152 chr6:167472062 A/G cg07741184 chr6:167504864 NA 0.36 10.44 0.38 1.19e-23 Crohn's disease; BRCA trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg00717180 chr2:96193071 NA -0.31 -8.54 -0.32 9.83e-17 Coronary artery disease; BRCA trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21659725 chr3:3221576 CRBN -0.47 -11.88 -0.43 1.56e-29 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs6668215 chr1:152964498 A/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.62 -0.32 5.33e-17 Inflammatory skin disease; BRCA cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.75e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg26395211 chr5:140044315 WDR55 0.35 7.98 0.3 6.55e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs68170813 0.559 rs2249043 chr7:106960515 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.76 -0.33 1.77e-17 Coronary artery disease; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18758796 chr5:131593413 PDLIM4 0.39 9.94 0.37 9.96e-22 Acylcarnitine levels; BRCA cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg21475434 chr5:93447410 FAM172A 0.66 8.71 0.33 2.68e-17 Diabetic retinopathy; BRCA cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg15103426 chr22:29168792 CCDC117 0.49 9.79 0.36 3.45e-21 Lymphocyte counts; BRCA cis rs4268898 0.636 rs72787385 chr2:24585820 G/A cg06627628 chr2:24431161 ITSN2 -0.84 -15.29 -0.52 3.32e-45 Asthma; BRCA cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.1 0.49 1.71e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17253792 0.822 rs10083303 chr14:56068521 T/C cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg07952391 chr2:88470173 THNSL2 0.57 8.09 0.3 3.05e-15 Plasma clusterin levels; BRCA cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -11.2 -0.41 9.98e-27 Response to bleomycin (chromatid breaks); BRCA cis rs6866344 0.570 rs1071881 chr5:178135917 C/T cg10224037 chr5:178157518 ZNF354A 0.8 18.29 0.59 1.93e-60 Neutrophil percentage of white cells; BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg21143896 chr7:2802374 GNA12 -0.35 -8.88 -0.33 6.96e-18 Height; BRCA trans rs7181230 0.961 rs7183977 chr15:40377092 C/T cg22705835 chr10:65332833 REEP3 0.44 9.85 0.36 2.06e-21 Dehydroepiandrosterone sulphate levels; BRCA cis rs7666738 0.546 rs13105521 chr4:98734419 C/T cg05340658 chr4:99064831 C4orf37 0.56 11.11 0.4 2.53e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs12579753 1.000 rs17692461 chr12:82171755 C/G cg07988820 chr12:82153109 PPFIA2 -0.63 -10.44 -0.38 1.19e-23 Resting heart rate; BRCA cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg01579765 chr21:45077557 HSF2BP -0.42 -11.41 -0.41 1.44e-27 Mean corpuscular volume; BRCA cis rs9790314 1.000 rs336579 chr3:161086610 G/A cg03342759 chr3:160939853 NMD3 -0.53 -11.37 -0.41 2.12e-27 Morning vs. evening chronotype; BRCA cis rs1865760 0.688 rs9379814 chr6:25979869 C/T cg16482183 chr6:26056742 HIST1H1C 0.5 10.27 0.38 5.38e-23 Height; BRCA cis rs9462846 0.919 rs9462844 chr6:42856502 T/G cg02353165 chr6:42928485 GNMT 0.44 8.19 0.31 1.44e-15 Blood protein levels; BRCA cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg21573476 chr21:45109991 RRP1B -0.32 -8.29 -0.31 6.57e-16 Mean corpuscular volume; BRCA cis rs3740540 0.530 rs4297414 chr10:126292116 T/G cg04949429 chr10:126290192 LHPP 0.43 11.96 0.43 6.87e-30 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg27170947 chr2:26402098 FAM59B -0.79 -12.58 -0.45 1.34e-32 Gut microbiome composition (summer); BRCA cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg13628971 chr7:2884303 GNA12 0.51 9.88 0.36 1.61e-21 Height; BRCA cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.5 -11.15 -0.4 1.63e-26 Calcium levels; BRCA cis rs34779708 0.733 rs12240638 chr10:35542610 G/T cg03585969 chr10:35415529 CREM 0.45 9.18 0.34 6.03e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs798554 0.704 rs709282 chr7:2769921 G/A cg09658497 chr7:2847517 GNA12 -0.39 -8.0 -0.3 5.75e-15 Height; BRCA cis rs72781680 0.716 rs2712050 chr2:24059408 A/C cg08917208 chr2:24149416 ATAD2B 0.6 10.25 0.38 6.06e-23 Lymphocyte counts; BRCA cis rs6484504 0.625 rs1535741 chr11:31375072 T/C cg14844989 chr11:31128820 NA 0.44 9.67 0.36 9.56e-21 Red blood cell count; BRCA cis rs2370759 1.000 rs79487858 chr10:32616405 T/C cg18270830 chr10:32634957 EPC1 0.6 10.44 0.38 1.1e-23 Sexual dysfunction (female); BRCA cis rs765787 0.530 rs2899378 chr15:45537584 C/T cg24006582 chr15:45444508 DUOX1 0.55 10.72 0.39 9.44e-25 Uric acid levels; BRCA trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg25214090 chr10:38739885 LOC399744 0.57 12.97 0.46 2.58e-34 Corneal astigmatism; BRCA cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg06552810 chr11:31128660 NA -0.39 -8.71 -0.33 2.51e-17 Red blood cell count; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg00339695 chr16:24857497 SLC5A11 0.49 9.71 0.36 6.87e-21 Intelligence (multi-trait analysis); BRCA cis rs12458462 0.892 rs35928863 chr18:77438956 A/G cg11879182 chr18:77439856 CTDP1 0.64 13.99 0.48 5.41e-39 Monocyte count; BRCA cis rs6964587 1.000 rs7784248 chr7:91758111 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.14 0.31 2.09e-15 Breast cancer; BRCA cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg13902645 chr11:5959945 NA -0.49 -10.0 -0.37 5.84e-22 DNA methylation (variation); BRCA cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg06115741 chr20:33292138 TP53INP2 0.37 8.27 0.31 8.07e-16 Glomerular filtration rate (creatinine); BRCA cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg06636001 chr8:8085503 FLJ10661 0.58 11.68 0.42 1.08e-28 Neuroticism; BRCA cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.65 -0.36 1.19e-20 Mean corpuscular volume; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs372883 0.638 rs117213 chr21:30720536 G/A cg08807101 chr21:30365312 RNF160 -0.43 -9.14 -0.34 8.02e-19 Pancreatic cancer; BRCA cis rs9818758 0.607 rs56306491 chr3:49314960 G/A cg00383909 chr3:49044727 WDR6 0.92 13.81 0.48 3.6e-38 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1401999 1.000 rs1402002 chr3:183642794 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.16 0.37 1.4e-22 Anterior chamber depth; BRCA cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg21132104 chr15:45694354 SPATA5L1 0.75 16.9 0.56 3.2e-53 Homoarginine levels; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13732083 chr21:47605072 C21orf56 -0.38 -7.88 -0.3 1.42e-14 Testicular germ cell tumor; BRCA cis rs6545883 0.783 rs6545888 chr2:61845215 T/G cg15711740 chr2:61764176 XPO1 -0.48 -11.7 -0.42 8.37e-29 Tuberculosis; BRCA cis rs514406 0.929 rs562178 chr1:53319562 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -11.61 -0.42 2.03e-28 Monocyte count; BRCA cis rs6745190 0.557 rs34504038 chr2:181992954 T/G cg00481216 chr2:181971175 NA 0.47 8.89 0.33 6.33e-18 White blood cell count; BRCA cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg02175503 chr12:58329896 NA 0.45 8.58 0.32 7.21e-17 Intelligence (multi-trait analysis); BRCA cis rs7927592 0.956 rs11228258 chr11:68254328 A/C cg20283391 chr11:68216788 NA 0.45 9.3 0.35 2.13e-19 Total body bone mineral density; BRCA cis rs911186 0.891 rs6914824 chr6:27139048 C/T cg12292205 chr6:26970375 C6orf41 -0.65 -10.03 -0.37 4.55e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg15242686 chr22:24348715 GSTTP1 0.33 7.86 0.3 1.62e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs801193 1.000 rs3800812 chr7:66223461 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.35 0.31 4.08e-16 Aortic root size; BRCA cis rs6840258 1.000 rs72667759 chr4:87952199 C/G cg08197287 chr4:87952173 AFF1 -0.45 -8.81 -0.33 1.13e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26314531 chr2:26401878 FAM59B -0.66 -11.25 -0.41 6.5e-27 Gut microbiome composition (summer); BRCA cis rs34779708 0.931 rs4007289 chr10:35269790 G/A cg03585969 chr10:35415529 CREM 0.49 10.1 0.37 2.44e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg05868516 chr6:26286170 HIST1H4H 0.49 10.97 0.4 8.67e-26 Educational attainment; BRCA cis rs3087591 0.922 rs2905801 chr17:29524974 C/T cg24425628 chr17:29625626 OMG;NF1 0.41 7.97 0.3 7.44e-15 Hip circumference; BRCA cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.94e-23 Mean platelet volume; BRCA cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg00750074 chr16:89608354 SPG7 -0.37 -9.78 -0.36 3.68e-21 Multiple myeloma (IgH translocation); BRCA cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg03864215 chr11:17408437 KCNJ11 -0.27 -8.18 -0.31 1.48e-15 Type 2 diabetes; BRCA cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -10.77 -0.39 5.57e-25 Type 2 diabetes; BRCA cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg19628046 chr18:33552617 C18orf21 0.54 11.15 0.4 1.69e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs3768617 0.510 rs12091137 chr1:183075732 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.82 0.58 5.95e-58 Fuchs's corneal dystrophy; BRCA trans rs2204008 0.837 rs11168387 chr12:37962818 G/A cg06521331 chr12:34319734 NA 0.45 8.87 0.33 7.15e-18 Bladder cancer; BRCA cis rs9646954 0.542 rs4149513 chr2:101022726 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.52 0.41 4.71e-28 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg20476274 chr7:133979776 SLC35B4 0.6 15.08 0.51 3.63e-44 Mean platelet volume; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg08888203 chr3:10149979 C3orf24 0.65 13.7 0.48 1.19e-37 Alzheimer's disease; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11141652 chr22:24348549 GSTTP1 0.43 8.72 0.33 2.4e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs6901250 0.632 rs688961 chr6:117089080 A/T cg12892004 chr6:117198278 RFX6 0.35 8.65 0.32 4.23e-17 C-reactive protein levels; BRCA cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg11764359 chr7:65958608 NA -0.62 -13.14 -0.46 4.35e-35 Aortic root size; BRCA cis rs317689 0.918 rs581911 chr12:69738293 C/T cg14784868 chr12:69753453 YEATS4 0.45 9.03 0.34 1.95e-18 Response to diuretic therapy; BRCA cis rs73086581 0.947 rs17287577 chr20:3966254 C/T cg02187196 chr20:3869020 PANK2 0.54 9.56 0.35 2.59e-20 Response to antidepressants in depression; BRCA cis rs6032067 0.673 rs36019441 chr20:43892401 G/A cg06407657 chr20:43937138 MATN4;RBPJL 0.31 8.18 0.31 1.54e-15 Blood protein levels; BRCA cis rs3820928 0.874 rs7605032 chr2:227847630 T/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.39 -0.32 3.08e-16 Pulmonary function; BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.17 -0.31 1.6e-15 Aortic root size; BRCA trans rs2204008 0.782 rs117824012 chr12:38215517 T/C cg06521331 chr12:34319734 NA -0.54 -9.77 -0.36 4.1e-21 Bladder cancer; BRCA cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg06046430 chr4:77819534 ANKRD56 0.58 12.8 0.45 1.42e-33 Emphysema distribution in smoking; BRCA cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg04455712 chr21:45112962 RRP1B -0.43 -11.56 -0.42 3.29e-28 Mean corpuscular volume; BRCA cis rs6598955 0.543 rs12122527 chr1:26549748 C/T cg04990556 chr1:26633338 UBXN11 0.7 12.25 0.44 3.77e-31 Obesity-related traits; BRCA cis rs11764590 0.694 rs3996323 chr7:2079428 G/T cg23422044 chr7:1970798 MAD1L1 -0.44 -9.4 -0.35 9.71e-20 Neuroticism; BRCA cis rs3771570 1.000 rs62193210 chr2:242323616 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.18 0.34 5.69e-19 Prostate cancer; BRCA cis rs9818758 0.607 rs35060561 chr3:49255503 T/C cg00383909 chr3:49044727 WDR6 0.77 12.81 0.45 1.35e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7100689 0.516 rs3862532 chr10:82015725 A/C cg01528321 chr10:82214614 TSPAN14 0.71 15.97 0.53 1.47e-48 Post bronchodilator FEV1; BRCA cis rs2304069 0.954 rs6861548 chr5:149384680 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.84 16.95 0.56 1.78e-53 HIV-1 control; BRCA cis rs722599 0.683 rs8011071 chr14:75286705 T/C cg08847533 chr14:75593920 NEK9 0.43 8.02 0.3 5.18e-15 IgG glycosylation; BRCA cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg00071950 chr4:10020882 SLC2A9 0.67 16.82 0.55 7.99e-53 Bone mineral density; BRCA cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.63 -0.42 1.68e-28 Glomerular filtration rate (creatinine); BRCA cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg18016565 chr1:150552671 MCL1 0.34 8.01 0.3 5.63e-15 Tonsillectomy; BRCA cis rs8180040 0.726 rs61729713 chr3:47027192 A/G cg27129171 chr3:47204927 SETD2 -0.59 -13.57 -0.47 4.98e-37 Colorectal cancer; BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.03 0.3 4.62e-15 Tonsillectomy; BRCA cis rs2120243 0.845 rs2305619 chr3:157154861 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.4 8.76 0.33 1.81e-17 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg03433033 chr1:76189801 ACADM 0.64 11.41 0.41 1.39e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1577917 1.000 rs12190598 chr6:86686074 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.48 -12.57 -0.45 1.62e-32 Response to antipsychotic treatment; BRCA cis rs72781680 0.716 rs6718631 chr2:24036086 A/G cg08917208 chr2:24149416 ATAD2B -0.59 -10.15 -0.37 1.53e-22 Lymphocyte counts; BRCA cis rs2070488 0.662 rs6599202 chr3:38480651 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.55 12.92 0.46 4.38e-34 Electrocardiographic conduction measures; BRCA cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg03433033 chr1:76189801 ACADM -0.76 -17.35 -0.57 1.57e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg00071950 chr4:10020882 SLC2A9 -0.46 -10.94 -0.4 1.13e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7715806 0.500 rs17563589 chr5:74980019 A/G cg19683494 chr5:74908142 NA 0.53 8.58 0.32 7.02e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg25554036 chr4:6271136 WFS1 0.44 10.48 0.38 7.8e-24 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg23711669 chr6:146136114 FBXO30 0.78 18.79 0.6 4.89e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs17376456 0.877 rs13153245 chr5:93374891 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 8.05 0.3 4.15e-15 Diabetic retinopathy; BRCA cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.89 0.72 1.21e-101 Chronic sinus infection; BRCA cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg21535247 chr6:8435926 SLC35B3 0.41 9.24 0.34 3.57e-19 Motion sickness; BRCA cis rs72634258 0.554 rs13306061 chr1:7913445 C/T cg26816564 chr1:7831052 VAMP3 0.54 10.4 0.38 1.68e-23 Inflammatory bowel disease; BRCA cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg08999081 chr20:33150536 PIGU -0.44 -12.15 -0.43 1.01e-30 Glomerular filtration rate (creatinine); BRCA cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg24229701 chr12:130821962 PIWIL1 0.39 8.89 0.33 6.08e-18 Menopause (age at onset); BRCA cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg25208724 chr1:156163844 SLC25A44 -1.06 -35.94 -0.82 1.46e-155 Testicular germ cell tumor; BRCA cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg06238570 chr21:40685208 BRWD1 0.4 8.04 0.3 4.48e-15 Cognitive function; BRCA cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.82 -0.33 1.08e-17 Developmental language disorder (linguistic errors); BRCA cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg08975724 chr8:8085496 FLJ10661 -0.5 -10.66 -0.39 1.56e-24 Mood instability; BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg10729496 chr3:10149963 C3orf24 0.48 8.98 0.33 2.93e-18 Alzheimer's disease; BRCA cis rs9814567 1.000 rs6790466 chr3:134197740 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.46 -0.61 1.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg02175503 chr12:58329896 NA 0.56 13.34 0.47 5.6e-36 Intelligence (multi-trait analysis); BRCA cis rs11030122 0.702 rs12286710 chr11:3967171 T/G cg18678763 chr11:4115507 RRM1 -0.37 -8.67 -0.32 3.44e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg25478527 chr11:95522999 CEP57;FAM76B -0.37 -8.13 -0.31 2.23e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA trans rs526821 0.595 rs485555 chr11:55323570 A/G cg15704280 chr7:45808275 SEPT13 0.41 7.87 0.3 1.56e-14 Pediatric bone mineral density (spine); BRCA cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg22974920 chr21:40686053 BRWD1 -0.4 -8.74 -0.33 2.01e-17 Cognitive function; BRCA cis rs6541297 0.887 rs4846906 chr1:230284257 C/A cg20703242 chr1:230279135 GALNT2 0.42 8.3 0.31 6.04e-16 Coronary artery disease; BRCA cis rs4953318 0.619 rs13406773 chr2:46362868 T/C cg12428440 chr2:46370979 PRKCE 0.49 10.76 0.39 6.19e-25 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg12310025 chr6:25882481 NA -0.5 -12.1 -0.43 1.71e-30 Blood metabolite levels; BRCA cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg21399703 chr1:247681439 NA 0.49 10.5 0.38 6.53e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg24642439 chr20:33292090 TP53INP2 0.61 13.6 0.47 3.42e-37 Coronary artery disease; BRCA cis rs7336332 0.598 rs7669 chr13:28009851 C/T cg22138327 chr13:27999177 GTF3A 0.65 11.57 0.42 2.92e-28 Weight; BRCA cis rs3772130 0.603 rs10470410 chr3:121434977 G/T cg20356878 chr3:121714668 ILDR1 0.37 8.27 0.31 7.51e-16 Cognitive performance; BRCA cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.46 -0.32 1.83e-16 Monocyte percentage of white cells; BRCA cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.02 0.3 5.14e-15 Breast cancer; BRCA cis rs490234 0.702 rs35237975 chr9:128313867 A/G cg14078157 chr9:128172775 NA -0.53 -11.58 -0.42 2.68e-28 Mean arterial pressure; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg00106254 chr7:1943704 MAD1L1 -0.47 -12.61 -0.45 1.07e-32 Bipolar disorder and schizophrenia; BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.81 12.15 0.43 9.98e-31 Platelet count; BRCA trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21582582 chr3:182698605 DCUN1D1 0.4 10.41 0.38 1.49e-23 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs1541574 chr2:10773508 A/T cg00105475 chr2:10696890 NA 0.43 9.83 0.36 2.47e-21 Prostate cancer; BRCA cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.55 -0.35 2.64e-20 Tonsillectomy; BRCA cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg17971929 chr21:40555470 PSMG1 -0.62 -14.48 -0.5 2.58e-41 Cognitive function; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg02951883 chr7:2050386 MAD1L1 -0.37 -8.24 -0.31 9.67e-16 Bipolar disorder and schizophrenia; BRCA cis rs3812049 0.826 rs34576922 chr5:127364103 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.59 -11.17 -0.4 1.4e-26 Lymphocyte counts;Red cell distribution width; BRCA cis rs425277 1.000 rs262676 chr1:2078482 T/A cg24578937 chr1:2090814 PRKCZ 0.57 17.81 0.58 6.82e-58 Height; BRCA trans rs3857536 0.740 rs9354390 chr6:66890162 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.46 9.12 0.34 1e-18 Blood trace element (Cu levels); BRCA cis rs733592 0.524 rs10875727 chr12:48426143 T/C cg24011408 chr12:48396354 COL2A1 -0.45 -9.98 -0.37 6.85e-22 Plateletcrit; BRCA trans rs61931739 0.534 rs28548399 chr12:34188151 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.54 0.5 1.35e-41 Morning vs. evening chronotype; BRCA cis rs72781680 0.768 rs56339558 chr2:24125234 G/A cg08917208 chr2:24149416 ATAD2B 0.62 10.54 0.38 4.72e-24 Lymphocyte counts; BRCA cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.56 0.67 2.43e-83 Chronic sinus infection; BRCA cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg21518248 chr2:162101506 NA 0.71 17.54 0.57 1.55e-56 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA trans rs2204008 0.623 rs1607878 chr12:38376000 A/G cg06521331 chr12:34319734 NA -0.46 -8.83 -0.33 1.01e-17 Bladder cancer; BRCA cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.79 22.15 0.66 4.42e-81 Chronic sinus infection; BRCA cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg11833968 chr6:79620685 NA -0.39 -8.47 -0.32 1.72e-16 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg21573476 chr21:45109991 RRP1B 0.34 9.03 0.34 2.06e-18 Mean corpuscular volume; BRCA cis rs4363385 0.597 rs6679201 chr1:152976840 C/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.57e-16 Inflammatory skin disease; BRCA cis rs10046574 0.519 rs9656456 chr7:135202208 G/A cg27474649 chr7:135195673 CNOT4 0.67 11.09 0.4 3.01e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4595586 0.525 rs7313120 chr12:39388027 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.44 0.35 6.82e-20 Morning vs. evening chronotype; BRCA cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.69 0.57 2.73e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs8038465 0.622 rs710086 chr15:73877001 C/T cg15420318 chr15:73925796 NPTN 0.48 10.05 0.37 3.73e-22 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg11764359 chr7:65958608 NA -0.62 -13.27 -0.46 1.09e-35 Aortic root size; BRCA cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg16179182 chr5:140090404 VTRNA1-1 0.46 10.9 0.4 1.73e-25 Depressive symptoms (multi-trait analysis); BRCA trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg15556689 chr8:8085844 FLJ10661 -0.35 -9.48 -0.35 4.87e-20 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs17685 0.753 rs4573217 chr7:75733946 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.22 -0.31 1.14e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.08 -0.34 1.35e-18 Developmental language disorder (linguistic errors); BRCA cis rs4803468 1.000 rs10422956 chr19:41901261 C/T cg09537434 chr19:41945824 ATP5SL -0.98 -23.4 -0.68 6.38e-88 Height; BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg21782813 chr7:2030301 MAD1L1 0.35 9.36 0.35 1.35e-19 Schizophrenia; BRCA cis rs911119 0.913 rs6036461 chr20:23576754 C/G cg16589663 chr20:23618590 CST3 0.4 7.99 0.3 6.34e-15 Chronic kidney disease; BRCA cis rs9925964 0.748 rs4889603 chr16:30982225 C/T cg02466173 chr16:30829666 NA -0.45 -9.09 -0.34 1.19e-18 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2018683 1.000 rs4719963 chr7:29011064 A/G cg19402173 chr7:128379420 CALU 0.56 14.04 0.49 3.25e-39 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs2120243 1.000 rs10936090 chr3:157142754 A/C cg01018701 chr3:157155998 VEPH1;PTX3 0.41 9.09 0.34 1.28e-18 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs1152591 0.643 rs3020449 chr14:64773392 C/T cg21174375 chr14:64681225 SYNE2 -0.36 -8.15 -0.31 1.86e-15 Atrial fibrillation; BRCA cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg18876405 chr7:65276391 NA -0.49 -10.84 -0.39 3.06e-25 Aortic root size; BRCA cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg08885076 chr2:99613938 TSGA10 -0.45 -10.53 -0.38 5.11e-24 Chronic sinus infection; BRCA cis rs13040088 1.000 rs10854167 chr20:61533039 G/C cg23096297 chr20:61557774 DIDO1 0.88 17.77 0.58 1.07e-57 Menopause (age at onset); BRCA cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg03709012 chr19:19516395 GATAD2A -0.75 -16.77 -0.55 1.34e-52 Tonsillectomy; BRCA cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 10.84 0.39 3.02e-25 Height; BRCA cis rs9341808 0.754 rs9352817 chr6:81025879 T/G cg08355045 chr6:80787529 NA 0.35 9.23 0.34 3.85e-19 Sitting height ratio; BRCA cis rs2554380 0.943 rs2585040 chr15:84340468 G/C cg14598478 chr15:84363061 ADAMTSL3 -0.32 -7.96 -0.3 7.7e-15 Height; BRCA cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg09526685 chr4:187126073 CYP4V2 1.01 12.05 0.43 2.91e-30 Blood protein levels; BRCA cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg06784218 chr1:46089804 CCDC17 0.48 11.63 0.42 1.68e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg03146154 chr1:46216737 IPP 0.45 10.03 0.37 4.49e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg12365402 chr11:9010492 NRIP3 -0.37 -8.35 -0.31 4.12e-16 Hemoglobin concentration; BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg24829409 chr8:58192753 C8orf71 -0.49 -8.44 -0.32 2.19e-16 Developmental language disorder (linguistic errors); BRCA trans rs2739330 0.731 rs5751792 chr22:24401542 G/A cg06437703 chr8:37914619 EIF4EBP1 -0.4 -10.71 -0.39 9.95e-25 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17125944 0.505 rs2274275 chr14:53235728 G/T cg13660082 chr14:53194042 PSMC6 -0.57 -8.12 -0.31 2.41e-15 Alzheimer's disease (late onset); BRCA trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg15934090 chr1:100435551 SLC35A3 0.36 8.22 0.31 1.11e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7809799 1.000 rs6975245 chr7:98755272 G/T cg05967295 chr7:98741636 SMURF1 -0.81 -8.11 -0.31 2.68e-15 Ulcerative colitis; BRCA trans rs6479891 1.000 rs10761745 chr10:65101071 C/G cg14819942 chr15:35414228 NA -0.33 -8.21 -0.31 1.24e-15 Arthritis (juvenile idiopathic); BRCA cis rs4818225 0.793 rs960231 chr21:42622657 C/G cg21268422 chr21:42620091 BACE2 0.46 8.6 0.32 6.19e-17 Educational attainment; BRCA cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9517320 0.534 rs4772088 chr13:99138270 T/G cg07423050 chr13:99094983 FARP1 -0.51 -11.28 -0.41 4.85e-27 Longevity; BRCA cis rs9287719 0.674 rs759399 chr2:10796883 T/C cg02196655 chr2:10830764 NOL10 0.29 7.81 0.3 2.35e-14 Prostate cancer; BRCA trans rs7786808 0.586 rs7794256 chr7:158206214 T/G cg02030672 chr11:45687055 CHST1 -0.43 -9.67 -0.36 9.51e-21 Obesity-related traits; BRCA cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1975974 0.872 rs17052352 chr17:21721972 A/G cg18423549 chr17:21743878 NA -0.52 -11.44 -0.41 1.08e-27 Psoriasis; BRCA trans rs7939886 0.920 rs11227222 chr11:55876393 G/T cg15704280 chr7:45808275 SEPT13 -0.62 -8.09 -0.3 2.93e-15 Myopia (pathological); BRCA cis rs735396 1.000 rs2464195 chr12:121435475 G/A cg02403541 chr12:121454288 C12orf43 0.54 10.3 0.38 3.9699999999999997e-23 N-glycan levels; BRCA cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg26874164 chr19:58962979 ZNF324B 0.44 9.39 0.35 1.08e-19 Uric acid clearance; BRCA cis rs11098499 0.779 rs7674500 chr4:120303593 C/T cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.75 -13.9 -0.48 1.48e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg02773041 chr1:40204384 PPIE 0.43 9.25 0.34 3.34e-19 Blood protein levels; BRCA cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.87 0.33 7.22e-18 Motion sickness; BRCA cis rs3818285 0.556 rs2084607 chr10:111681411 C/T cg00817464 chr10:111662876 XPNPEP1 0.35 9.69 0.36 8.44e-21 Superior crus of antihelix expression; BRCA cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg09467607 chr2:36825704 FEZ2 0.62 15.32 0.52 2.25e-45 Height; BRCA cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg27129171 chr3:47204927 SETD2 -0.64 -14.43 -0.5 4.62e-41 Colorectal cancer; BRCA cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15506890 chr2:3487001 NA -0.58 -13.14 -0.46 4.26e-35 Neurofibrillary tangles; BRCA cis rs13136331 0.721 rs2732186 chr4:88673987 T/C cg22416721 chr4:88570574 DMP1 -0.51 -11.61 -0.42 2.04e-28 Sitting height ratio; BRCA cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg02079420 chr8:82753780 SNX16 0.31 7.94 0.3 9.08e-15 Diastolic blood pressure; BRCA trans rs61931739 0.534 rs4086956 chr12:34105047 A/T cg13010199 chr12:38710504 ALG10B 0.4 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs10476599 chr5:93383423 A/G cg25358565 chr5:93447407 FAM172A 1.2 18.58 0.59 6.04e-62 Diabetic retinopathy; BRCA cis rs3820928 0.934 rs60141402 chr2:227761445 A/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.36 -0.31 3.79e-16 Pulmonary function; BRCA trans rs7824557 0.628 rs11250129 chr8:11202154 G/A cg06636001 chr8:8085503 FLJ10661 0.4 8.24 0.31 9.56e-16 Retinal vascular caliber; BRCA cis rs7582180 0.700 rs11685401 chr2:100976685 A/G cg14675211 chr2:100938903 LONRF2 0.4 8.99 0.34 2.77e-18 Intelligence (multi-trait analysis); BRCA cis rs6963495 0.818 rs1721498 chr7:105178819 A/C cg19920283 chr7:105172520 RINT1 -0.64 -13.08 -0.46 7.89e-35 Bipolar disorder (body mass index interaction); BRCA cis rs1865721 1.000 rs62089509 chr18:73194519 G/A cg26385618 chr18:73139727 C18orf62 -0.39 -9.03 -0.34 2.07e-18 Intelligence; BRCA cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg08085267 chr17:45401833 C17orf57 -0.59 -12.06 -0.43 2.63e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg21782813 chr7:2030301 MAD1L1 0.43 12.34 0.44 1.53e-31 Bipolar disorder and schizophrenia; BRCA cis rs875971 1.000 rs778696 chr7:65870813 C/G cg11764359 chr7:65958608 NA 0.8 19.49 0.61 9.4e-67 Aortic root size; BRCA cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg13175981 chr1:150552382 MCL1 0.47 10.54 0.38 4.68e-24 Lymphocyte counts; BRCA cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg06636001 chr8:8085503 FLJ10661 -0.48 -10.0 -0.37 5.64e-22 Joint mobility (Beighton score); BRCA cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg01579765 chr21:45077557 HSF2BP -0.42 -11.64 -0.42 1.5e-28 Mean corpuscular volume; BRCA cis rs3743102 0.527 rs117959961 chr15:83339895 C/T cg00614314 chr15:82944287 LOC80154 -0.59 -8.18 -0.31 1.54e-15 Colorectal adenoma (advanced); BRCA cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.11 0.43 1.51e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.8 17.14 0.56 1.93e-54 Smoking behavior; BRCA trans rs9858542 1.000 rs9882740 chr3:49702484 T/C cg21659725 chr3:3221576 CRBN -0.46 -9.71 -0.36 7.18e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs17253792 0.822 rs75663029 chr14:56092385 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs12431939 1.000 rs4567626 chr14:51647640 A/T cg23942311 chr14:51606299 NA 0.41 8.01 0.3 5.46e-15 Cancer; BRCA cis rs9875589 0.509 rs2733556 chr3:14100172 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.33 8.72 0.33 2.41e-17 Ovarian reserve; BRCA cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg09658497 chr7:2847517 GNA12 -0.39 -7.97 -0.3 7.12e-15 Height; BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -13.97 -0.48 6.65e-39 Platelet count; BRCA cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg06092702 chr1:163392909 NA -0.36 -9.6 -0.35 1.85e-20 Motion sickness; BRCA cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.99 0.3 6.4e-15 Depression; BRCA cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg26769984 chr7:1090371 C7orf50 0.49 9.17 0.34 6.59e-19 Bronchopulmonary dysplasia; BRCA cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg02175503 chr12:58329896 NA 0.56 13.26 0.46 1.23e-35 Intelligence (multi-trait analysis); BRCA cis rs3740540 0.507 rs942015 chr10:126289932 G/T cg04949429 chr10:126290192 LHPP 0.44 12.33 0.44 1.73e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.45 -0.38 1.07e-23 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg25427524 chr10:38739819 LOC399744 0.66 16.21 0.54 9.7e-50 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg23788917 chr6:8435910 SLC35B3 -0.47 -10.22 -0.37 8.45e-23 Motion sickness; BRCA cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.54 10.22 0.37 7.92e-23 Aortic root size; BRCA cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.46 -9.29 -0.35 2.34e-19 Tonsillectomy; BRCA cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg16179182 chr5:140090404 VTRNA1-1 0.45 10.72 0.39 9.38e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs752010 0.684 rs10789402 chr1:42084649 A/G cg06885757 chr1:42089581 HIVEP3 0.3 10.74 0.39 7.23e-25 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs11679564 0.714 rs4016031 chr2:37184754 C/T cg14987922 chr2:37194071 STRN 0.4 8.24 0.31 1e-15 Immature fraction of reticulocytes; BRCA cis rs243505 1.000 rs243511 chr7:148430148 A/C cg09806900 chr7:148480153 CUL1 -0.44 -8.9 -0.33 5.96e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1707322 1.000 rs2458400 chr1:46530798 C/T cg06784218 chr1:46089804 CCDC17 -0.44 -10.53 -0.38 5.14e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17270561 0.608 rs4711102 chr6:25742075 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg24112000 chr20:60950667 NA 0.53 11.37 0.41 2.04e-27 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.19 -0.34 5.6e-19 Tonsillectomy; BRCA cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg03146154 chr1:46216737 IPP 0.53 11.98 0.43 5.79e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17253792 0.822 rs28549152 chr14:56091239 A/G cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs2288073 0.965 rs10469924 chr2:24416230 G/A cg06627628 chr2:24431161 ITSN2 -0.64 -12.47 -0.44 4.44e-32 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs3849570 0.961 rs13340130 chr3:81790970 A/T cg07356753 chr3:81810745 GBE1 -0.47 -11.41 -0.41 1.35e-27 Waist circumference;Body mass index; BRCA trans rs8073060 0.586 rs225305 chr17:33921160 C/T cg19694781 chr19:47549865 TMEM160 -1.02 -21.11 -0.64 1.88e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -11.27 -0.41 5.34e-27 Triglycerides; BRCA cis rs1577917 0.958 rs12192546 chr6:86476484 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.59 15.55 0.52 1.78e-46 Response to antipsychotic treatment; BRCA cis rs10193935 0.786 rs10178087 chr2:42409631 C/A cg27598129 chr2:42591480 NA -0.91 -14.5 -0.5 2.15e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.31 -0.31 5.73e-16 Colorectal cancer; BRCA cis rs738322 1.000 rs4382 chr22:38570842 T/C cg25457927 chr22:38595422 NA -0.32 -11.89 -0.43 1.34e-29 Cutaneous nevi; BRCA cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg13393036 chr8:95962371 TP53INP1 -0.34 -9.12 -0.34 1.01e-18 Type 2 diabetes; BRCA cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg09184832 chr6:79620586 NA -0.47 -10.07 -0.37 3.08e-22 Intelligence (multi-trait analysis); BRCA trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg27661571 chr11:113659931 NA -0.83 -12.29 -0.44 2.55e-31 Hip circumference adjusted for BMI; BRCA cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg08847533 chr14:75593920 NEK9 -0.94 -24.86 -0.7 5.75e-96 Height; BRCA cis rs2066819 1.000 rs59811639 chr12:56695954 C/T cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs6582630 0.519 rs1607868 chr12:38385512 G/T cg13010199 chr12:38710504 ALG10B 0.49 10.12 0.37 1.96e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs8062405 1.000 rs62036621 chr16:28833299 C/A cg16576597 chr16:28551801 NUPR1 0.3 8.42 0.32 2.52e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg08807101 chr21:30365312 RNF160 0.74 19.48 0.61 1.12e-66 Dental caries; BRCA cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg00339695 chr16:24857497 SLC5A11 0.34 7.92 0.3 1.03e-14 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs12997796 0.503 rs34492196 chr2:87021758 T/C cg25203885 chr2:87302643 LOC285074 -0.52 -8.49 -0.32 1.4e-16 Schizophrenia; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs875971 0.520 rs160645 chr7:65556307 A/G cg11764359 chr7:65958608 NA -0.64 -11.24 -0.41 6.96e-27 Aortic root size; BRCA cis rs2677744 0.626 rs11207 chr15:91497239 C/T cg23684204 chr15:91497937 RCCD1 0.46 9.52 0.35 3.4e-20 Attention deficit hyperactivity disorder; BRCA cis rs11098499 0.863 rs3775843 chr4:120427844 T/C cg09307838 chr4:120376055 NA 0.7 14.3 0.49 1.96e-40 Corneal astigmatism; BRCA cis rs3820928 0.874 rs3752896 chr2:227886925 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.44e-16 Pulmonary function; BRCA cis rs6740322 1.000 rs6756736 chr2:43558743 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -12.0 -0.43 4.47e-30 Coronary artery disease; BRCA cis rs6723226 0.767 rs10172308 chr2:32555760 G/A cg02381751 chr2:32503542 YIPF4 -0.72 -16.17 -0.54 1.45e-49 Intelligence (multi-trait analysis); BRCA cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg09035930 chr12:129282057 SLC15A4 0.51 14.64 0.5 4.86e-42 Systemic lupus erythematosus; BRCA cis rs9790314 0.690 rs6441354 chr3:160826404 A/G cg03342759 chr3:160939853 NMD3 -0.51 -10.51 -0.38 6.04e-24 Morning vs. evening chronotype; BRCA cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg01579765 chr21:45077557 HSF2BP -0.43 -11.77 -0.42 4.31e-29 Mean corpuscular volume; BRCA cis rs6598955 0.671 rs59143843 chr1:26641595 G/T cg04990556 chr1:26633338 UBXN11 0.54 9.0 0.34 2.58e-18 Obesity-related traits; BRCA trans rs634534 0.622 rs593525 chr11:65727799 T/C cg17712092 chr4:129076599 LARP1B 0.5 12.07 0.43 2.21e-30 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs1580019 0.922 rs766658 chr7:32499391 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.75 16.35 0.54 1.84e-50 Cognitive ability; BRCA cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg19318889 chr4:1322082 MAEA -0.59 -12.12 -0.43 1.43e-30 Longevity; BRCA cis rs2280018 0.963 rs12928424 chr16:15150773 C/G cg07549590 chr16:15018862 NA -0.36 -9.15 -0.34 7.32e-19 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.35 -9.78 -0.36 3.84e-21 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg20607798 chr8:58055168 NA 0.47 8.09 0.3 3.07e-15 Developmental language disorder (linguistic errors); BRCA cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.38 9.13 0.34 8.57e-19 Platelet count; BRCA cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.54 0.32 9.95e-17 Electroencephalogram traits; BRCA cis rs7646881 0.812 rs73017539 chr3:158460743 A/G cg19483011 chr3:158453295 NA -0.45 -7.97 -0.3 7.19e-15 Tetralogy of Fallot; BRCA cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.09 0.3 3.03e-15 Bladder cancer; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg19346786 chr7:2764209 NA -0.31 -8.95 -0.33 3.7e-18 Height; BRCA cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg08859206 chr1:53392774 SCP2 -0.62 -13.31 -0.47 7.72e-36 Monocyte count; BRCA cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24308560 chr3:49941425 MST1R 0.39 8.43 0.32 2.37e-16 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.04e-16 Developmental language disorder (linguistic errors); BRCA cis rs6025261 0.761 rs6099360 chr20:55511902 C/T cg04763273 chr20:55502381 NA -0.33 -7.99 -0.3 6.45e-15 Verbal memory performance (delayed recall level); BRCA cis rs7666738 0.791 rs1426674 chr4:98924247 C/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs838147 0.507 rs1704773 chr19:49209566 A/G cg21064579 chr19:49206444 FUT2 0.32 8.02 0.3 4.92e-15 Dietary macronutrient intake; BRCA cis rs5758511 0.680 rs5758682 chr22:42645202 C/T cg00645731 chr22:42541494 CYP2D7P1 0.59 11.03 0.4 5.16e-26 Birth weight; BRCA cis rs1003719 0.715 rs9974494 chr21:38566566 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.47 -0.5 2.85e-41 Eye color traits; BRCA cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg12011299 chr4:100065546 ADH4 0.53 12.95 0.46 3.03e-34 Alcohol dependence; BRCA trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg15704280 chr7:45808275 SEPT13 0.76 16.12 0.54 2.56e-49 Coronary artery disease; BRCA cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg04586622 chr2:25135609 ADCY3 -0.45 -11.45 -0.41 9.4e-28 Body mass index; BRCA cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg10518543 chr12:38710700 ALG10B 0.36 7.93 0.3 1.01e-14 Morning vs. evening chronotype; BRCA cis rs312274 0.505 rs17622354 chr12:41323480 C/T cg17827154 chr12:41323612 CNTN1 -0.42 -11.3 -0.41 4.06e-27 Metabolite levels (X-11787); BRCA cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg06636001 chr8:8085503 FLJ10661 0.66 15.03 0.51 6.36e-44 Parkinson's disease; BRCA cis rs1691799 0.899 rs1168327 chr12:66728842 G/A cg16791601 chr12:66731901 HELB -0.65 -17.46 -0.57 4.06e-56 White blood cell count (basophil); BRCA cis rs1003719 0.646 rs9985082 chr21:38501021 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.24 -0.49 3.73e-40 Eye color traits; BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.15 -0.31 1.89e-15 Total body bone mineral density; BRCA cis rs12310956 0.515 rs1830086 chr12:33958874 C/T cg06521331 chr12:34319734 NA -0.61 -11.11 -0.4 2.37e-26 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.8 0.33 1.28e-17 Motion sickness; BRCA cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg20701182 chr2:24300061 SF3B14 0.68 9.83 0.36 2.55e-21 Lymphocyte counts; BRCA cis rs1829883 0.835 rs2511977 chr5:98819617 A/G cg08333243 chr5:99726346 NA 0.35 7.91 0.3 1.1e-14 Hemostatic factors and hematological phenotypes; BRCA cis rs832540 0.695 rs702686 chr5:56201350 A/G cg24531977 chr5:56204891 C5orf35 -0.66 -14.55 -0.5 1.18e-41 Coronary artery disease; BRCA cis rs3008870 0.958 rs12131222 chr1:67438535 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs34779708 0.931 rs12261654 chr10:35322024 G/A cg03585969 chr10:35415529 CREM 0.47 10.02 0.37 4.7e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.73 0.57 1.65e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs6815814 0.861 rs6531663 chr4:38792340 T/C cg06935464 chr4:38784597 TLR10 0.49 9.7 0.36 7.89e-21 Breast cancer; BRCA trans rs11098499 0.863 rs11736416 chr4:120431661 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.13 0.31 2.16e-15 Corneal astigmatism; BRCA cis rs10929956 0.760 rs2729704 chr2:160707866 T/A cg18514922 chr2:160761262 LY75 -0.34 -7.97 -0.3 7.27e-15 Crohn's disease-related phenotypes; BRCA cis rs12950390 0.893 rs4239166 chr17:45847329 A/G cg03474202 chr17:45855739 NA -0.46 -12.57 -0.45 1.56e-32 IgG glycosylation; BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg08219700 chr8:58056026 NA 0.6 9.6 0.35 1.81e-20 Developmental language disorder (linguistic errors); BRCA cis rs9463078 0.739 rs1293467 chr6:44769204 C/G cg25276700 chr6:44698697 NA 0.4 9.18 0.34 5.91e-19 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1371867 0.846 rs1660351 chr8:101275034 C/T cg06636551 chr8:101224915 SPAG1 -0.35 -7.84 -0.3 1.84e-14 Atrioventricular conduction; BRCA cis rs10751667 1.000 rs7395691 chr11:985006 T/C ch.11.42038R chr11:967971 AP2A2 0.56 17.72 0.57 2e-57 Alzheimer's disease (late onset); BRCA cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg08999081 chr20:33150536 PIGU 0.36 9.27 0.34 2.78e-19 Coronary artery disease; BRCA trans rs9329221 0.662 rs4240645 chr8:10254463 C/G cg15556689 chr8:8085844 FLJ10661 -0.34 -8.09 -0.3 3e-15 Neuroticism; BRCA cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg19766460 chr21:43528205 UMODL1;C21orf128 0.8 17.4 0.57 8.4e-56 IgG glycosylation; BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs1865760 0.963 rs9356991 chr6:25901758 C/A cg16482183 chr6:26056742 HIST1H1C 0.54 11.24 0.41 7.04e-27 Height; BRCA cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg26248373 chr2:1572462 NA -0.51 -10.03 -0.37 4.22e-22 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg14019146 chr3:50243930 SLC38A3 -0.43 -10.43 -0.38 1.24e-23 Body mass index; BRCA cis rs10752881 0.967 rs8179361 chr1:182974572 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.71 0.55 2.93e-52 Colorectal cancer; BRCA cis rs6723226 0.803 rs387780 chr2:32502495 T/C cg02381751 chr2:32503542 YIPF4 0.67 13.85 0.48 2.45e-38 Intelligence (multi-trait analysis); BRCA cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06022373 chr22:39101656 GTPBP1 0.74 17.69 0.57 2.79e-57 Menopause (age at onset); BRCA cis rs7394190 0.748 rs79936644 chr10:75545117 C/T cg07699608 chr10:75541558 CHCHD1 0.66 10.0 0.37 5.62e-22 Incident atrial fibrillation; BRCA cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg22467129 chr15:76604101 ETFA -0.49 -10.77 -0.39 5.82e-25 Blood metabolite levels; BRCA cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg26597838 chr10:835615 NA 0.98 15.02 0.51 6.75e-44 Eosinophil percentage of granulocytes; BRCA cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg18876405 chr7:65276391 NA -0.62 -15.42 -0.52 7.35e-46 Aortic root size; BRCA cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg11301795 chr4:187892539 NA -0.28 -9.06 -0.34 1.61e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs2243480 1.000 rs34815098 chr7:65292254 A/C cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA trans rs61931739 0.500 rs7977194 chr12:34408459 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.74 0.36 5.26e-21 Morning vs. evening chronotype; BRCA cis rs7927771 0.524 rs1056387 chr11:47681370 A/C cg20307385 chr11:47447363 PSMC3 0.4 9.04 0.34 1.83e-18 Subjective well-being; BRCA cis rs7312933 0.558 rs11181507 chr12:42844763 T/A cg01256987 chr12:42539512 GXYLT1 -0.41 -7.93 -0.3 9.88e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg21747090 chr2:27597821 SNX17 -0.43 -9.36 -0.35 1.29e-19 Total body bone mineral density; BRCA cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg23583168 chr7:148888333 NA -0.83 -18.56 -0.59 7.99e-62 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg05707623 chr12:122985044 ZCCHC8 -0.47 -9.57 -0.35 2.24e-20 Body mass index; BRCA cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2880765 0.631 rs55767890 chr15:86004142 C/G cg10818794 chr15:86012489 AKAP13 -0.42 -11.41 -0.41 1.46e-27 Coronary artery disease; BRCA cis rs637571 0.565 rs633800 chr11:65638719 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.49 -10.05 -0.37 3.8e-22 Eosinophil percentage of white cells; BRCA cis rs7833986 0.534 rs72653928 chr8:56907735 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.71 0.45 3.73e-33 Height; BRCA cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -9.63 -0.36 1.38e-20 Monocyte percentage of white cells; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg00149659 chr3:10157352 C3orf10 0.8 13.67 0.48 1.69e-37 Alzheimer's disease; BRCA trans rs800082 0.501 rs9844730 chr3:144216886 T/G cg24215973 chr2:240111563 HDAC4 0.35 8.31 0.31 5.64e-16 Smoking behavior; BRCA cis rs250677 0.687 rs40523 chr5:148444186 A/T cg12140854 chr5:148520817 ABLIM3 0.41 8.85 0.33 8.72e-18 Breast cancer; BRCA cis rs9463078 0.774 rs7451423 chr6:45241343 C/T cg25276700 chr6:44698697 NA -0.35 -7.85 -0.3 1.77e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs11098499 0.863 rs10004484 chr4:120442428 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.87 0.3 1.51e-14 Corneal astigmatism; BRCA cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.04 -0.37 3.92e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg11952622 chr19:58962976 ZNF324B 0.43 8.75 0.33 1.95e-17 Uric acid clearance; BRCA cis rs796364 0.951 rs769952 chr2:200734368 C/T cg23649088 chr2:200775458 C2orf69 0.6 8.92 0.33 4.8e-18 Schizophrenia; BRCA cis rs2731664 0.792 rs385981 chr5:176886539 C/T cg23176889 chr5:176863531 GRK6 -0.61 -16.71 -0.55 2.98e-52 Intelligence (multi-trait analysis); BRCA cis rs7572733 0.555 rs700671 chr2:198690001 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.16 0.37 1.44e-22 Dermatomyositis; BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.27 0.56 4.14e-55 Alzheimer's disease; BRCA cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg05340658 chr4:99064831 C4orf37 0.66 16.1 0.54 3.26e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.43 0.32 2.29e-16 Rheumatoid arthritis; BRCA cis rs7737355 0.947 rs244739 chr5:130806874 A/C cg06307176 chr5:131281290 NA -0.53 -10.48 -0.38 8.24e-24 Life satisfaction; BRCA cis rs782590 0.774 rs782630 chr2:55899425 T/C cg18811423 chr2:55921094 PNPT1 0.78 26.62 0.73 1.31e-105 Metabolic syndrome; BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg16606324 chr3:10149918 C3orf24 0.57 11.38 0.41 1.87e-27 Alzheimer's disease; BRCA trans rs2204008 0.837 rs11183232 chr12:37941053 A/G cg06521331 chr12:34319734 NA -0.54 -10.31 -0.38 3.53e-23 Bladder cancer; BRCA cis rs11191270 0.590 rs12569901 chr10:104025410 C/G cg15320455 chr10:103880129 LDB1 0.75 11.22 0.41 8.29e-27 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg03929089 chr4:120376271 NA -0.43 -8.17 -0.31 1.7e-15 HDL cholesterol; BRCA cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg00677455 chr12:58241039 CTDSP2 0.39 8.65 0.32 4.32e-17 Intelligence (multi-trait analysis); BRCA cis rs1371614 0.513 rs13010712 chr2:27087709 T/A cg12368169 chr2:27073192 DPYSL5 -0.35 -10.26 -0.38 5.74e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg14403583 chr14:105418241 AHNAK2 0.37 8.51 0.32 1.27e-16 Rheumatoid arthritis; BRCA cis rs10754283 0.935 rs1934046 chr1:90119290 A/T cg21401794 chr1:90099060 LRRC8C -0.48 -11.0 -0.4 7.01e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2425143 1.000 rs7261284 chr20:34244104 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.97 -0.33 3.3e-18 Blood protein levels; BRCA cis rs798554 0.679 rs798499 chr7:2792013 G/A cg18446336 chr7:2847575 GNA12 -0.37 -8.66 -0.32 3.72e-17 Height; BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg22920501 chr2:26401640 FAM59B -0.59 -10.73 -0.39 8.42e-25 Gut microbiome composition (summer); BRCA cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg23711669 chr6:146136114 FBXO30 0.71 14.34 0.49 1.26e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg25767906 chr1:53392781 SCP2 -0.38 -8.7 -0.33 2.75e-17 Monocyte count; BRCA cis rs7618915 1.000 rs34569561 chr3:52287293 T/C cg18404041 chr3:52824283 ITIH1 -0.34 -9.3 -0.35 2.27e-19 Bipolar disorder; BRCA cis rs7267979 1.000 rs4815405 chr20:25317492 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.78 -0.36 3.81e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2882667 0.931 rs10075951 chr5:138355963 G/T cg04439458 chr5:138467593 SIL1 -0.33 -9.02 -0.34 2.2e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg08885076 chr2:99613938 TSGA10 -0.58 -12.99 -0.46 2.01e-34 Chronic sinus infection; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.75 16.25 0.54 5.61e-50 Lymphocyte counts; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.92 -0.3 1.05e-14 Total body bone mineral density; BRCA cis rs11098499 0.954 rs10031483 chr4:120422636 T/C cg09307838 chr4:120376055 NA 0.72 15.33 0.52 2.08e-45 Corneal astigmatism; BRCA cis rs11098499 0.955 rs35197422 chr4:120169314 T/G cg09307838 chr4:120376055 NA 0.61 12.35 0.44 1.42e-31 Corneal astigmatism; BRCA cis rs1355223 0.583 rs2915179 chr11:34871943 C/T cg11058730 chr11:34937778 PDHX;APIP 0.68 15.83 0.53 7.51e-48 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.78 -12.47 -0.44 4.35e-32 Platelet count; BRCA cis rs7607369 0.714 rs4674338 chr2:219647487 A/G cg02176678 chr2:219576539 TTLL4 0.46 12.44 0.44 5.57e-32 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg00173435 chr12:106696525 TCP11L2 0.57 10.06 0.37 3.42e-22 Tourette syndrome; BRCA trans rs11098499 0.954 rs28429722 chr4:120300093 G/A cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs1829883 1.000 rs2511973 chr5:98807871 T/A cg08333243 chr5:99726346 NA -0.36 -8.59 -0.32 6.81e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg18765753 chr7:1198926 ZFAND2A -0.5 -12.0 -0.43 4.82e-30 Longevity;Endometriosis; BRCA cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg13010199 chr12:38710504 ALG10B -0.41 -9.59 -0.35 2e-20 Heart rate; BRCA cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 8.92 0.33 4.8e-18 Personality dimensions; BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg00149659 chr3:10157352 C3orf10 1.08 18.29 0.59 1.95e-60 Alzheimer's disease; BRCA cis rs9790314 0.663 rs4557202 chr3:160820524 G/C cg03342759 chr3:160939853 NMD3 -0.53 -11.46 -0.41 8.46e-28 Morning vs. evening chronotype; BRCA cis rs7267979 0.966 rs6050567 chr20:25354561 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg00106254 chr7:1943704 MAD1L1 -0.42 -10.15 -0.37 1.56e-22 Bipolar disorder and schizophrenia; BRCA cis rs1865721 0.771 rs4410169 chr18:73138840 A/G cg26385618 chr18:73139727 C18orf62 -0.44 -10.78 -0.39 5.22e-25 Intelligence; BRCA cis rs367943 1.000 rs348929 chr5:112814883 T/A cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs17685 0.753 rs6465000 chr7:75787417 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2070488 0.766 rs6808093 chr3:38498160 T/C cg24069376 chr3:38537580 EXOG 0.32 9.08 0.34 1.36e-18 Electrocardiographic conduction measures; BRCA cis rs7737355 0.947 rs58895212 chr5:130797057 C/A cg06307176 chr5:131281290 NA -0.51 -10.26 -0.38 5.92e-23 Life satisfaction; BRCA trans rs11098499 0.866 rs72676074 chr4:120359841 A/C cg25214090 chr10:38739885 LOC399744 0.54 12.46 0.44 4.58e-32 Corneal astigmatism; BRCA cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg20503657 chr10:835505 NA 1.0 15.57 0.52 1.4e-46 Eosinophil percentage of granulocytes; BRCA cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg01448562 chr3:133502909 NA -0.41 -9.41 -0.35 8.84e-20 Iron status biomarkers; BRCA cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg05340658 chr4:99064831 C4orf37 0.59 12.67 0.45 5.43e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg22906224 chr7:99728672 NA 0.4 7.99 0.3 6.09e-15 Coronary artery disease; BRCA cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs2354432 0.556 rs12568866 chr1:146718430 A/C cg25205988 chr1:146714368 CHD1L -0.94 -13.46 -0.47 1.53e-36 Mitochondrial DNA levels; BRCA cis rs11677370 0.603 rs11696104 chr2:3849512 C/G cg17052675 chr2:3827356 NA -0.5 -12.25 -0.44 3.74e-31 Type 2 diabetes; BRCA cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg25173405 chr17:45401733 C17orf57 -0.5 -10.52 -0.38 5.55e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.13 0.34 9.24e-19 Resting heart rate; BRCA cis rs12310956 0.532 rs35366144 chr12:33992000 C/G cg06521331 chr12:34319734 NA -0.62 -11.21 -0.41 9.26e-27 Morning vs. evening chronotype; BRCA cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -9.03 -0.34 1.95e-18 Alzheimer's disease (late onset); BRCA trans rs11722228 0.508 rs3796826 chr4:10092728 G/A cg26043149 chr18:55253948 FECH 1.09 23.21 0.68 7.07e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs61931739 0.534 rs10844800 chr12:34230734 A/G cg06521331 chr12:34319734 NA -0.65 -12.08 -0.43 2.1000000000000002e-30 Morning vs. evening chronotype; BRCA cis rs6835098 1.000 rs6826412 chr4:174109622 C/T cg08422745 chr4:174089978 GALNT7 -0.78 -16.06 -0.54 5.51e-49 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs2404602 0.735 rs11635463 chr15:76762986 C/T cg23625390 chr15:77176239 SCAPER -0.51 -11.96 -0.43 7.15e-30 Blood metabolite levels; BRCA cis rs9467773 0.620 rs4368798 chr6:26593471 A/G cg09904177 chr6:26538194 HMGN4 0.47 15.0 0.51 8.32e-44 Intelligence (multi-trait analysis); BRCA cis rs10857712 0.950 rs10857711 chr10:135224059 G/A cg01444801 chr10:135216882 MTG1 -0.46 -10.37 -0.38 2.07e-23 Systemic lupus erythematosus; BRCA cis rs10782582 0.609 rs5745325 chr1:76269460 G/A cg03433033 chr1:76189801 ACADM -0.4 -8.08 -0.3 3.16e-15 Daytime sleep phenotypes; BRCA cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg24250549 chr1:154909240 PMVK 0.65 16.88 0.56 3.74e-53 Prostate cancer; BRCA cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg04267008 chr7:1944627 MAD1L1 0.52 11.47 0.41 7.72e-28 Bipolar disorder and schizophrenia; BRCA cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11644478 chr21:40555479 PSMG1 0.85 19.82 0.62 1.71e-68 Cognitive function; BRCA cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg25208724 chr1:156163844 SLC25A44 0.85 23.37 0.68 9.52e-88 Testicular germ cell tumor; BRCA cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7523050 0.643 rs35662800 chr1:109400816 C/A cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg20908204 chr19:46285434 DMPK -0.29 -8.6 -0.32 6.32e-17 Coronary artery disease; BRCA cis rs999943 0.774 rs12205634 chr6:33611667 C/G cg14003231 chr6:33640908 ITPR3 0.74 16.8 0.55 9.37e-53 Obesity (extreme); BRCA cis rs1577917 0.958 rs66807489 chr6:86440702 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.33 -0.44 1.71e-31 Response to antipsychotic treatment; BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg04944784 chr2:26401820 FAM59B 0.73 11.93 0.43 8.96e-30 Gut microbiome composition (summer); BRCA cis rs7607369 0.559 rs13027908 chr2:219660374 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -10.33 -0.38 3.02e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs75804782 0.641 rs11885523 chr2:239344263 G/A cg01134436 chr17:81009848 B3GNTL1 0.72 9.3 0.35 2.26e-19 Morning vs. evening chronotype;Chronotype; BRCA cis rs6430585 0.583 rs4988163 chr2:136628121 G/T cg07169764 chr2:136633963 MCM6 1.21 26.37 0.72 2.96e-104 Corneal structure; BRCA cis rs999943 0.846 rs9366826 chr6:33619184 C/G cg14003231 chr6:33640908 ITPR3 0.6 13.42 0.47 2.41e-36 Obesity (extreme); BRCA trans rs2797160 1.000 rs1739354 chr6:126017808 G/C cg05039488 chr6:79577232 IRAK1BP1 0.36 7.95 0.3 8.19e-15 Endometrial cancer; BRCA cis rs6582630 0.533 rs11181379 chr12:38332381 C/T cg26384229 chr12:38710491 ALG10B 0.4 9.62 0.36 1.46e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs6089584 0.924 rs6142906 chr20:60552554 G/C cg06108461 chr20:60628389 TAF4 -0.82 -17.52 -0.57 2.13e-56 Body mass index; BRCA cis rs12612619 0.542 rs6710065 chr2:27076557 C/T cg12368169 chr2:27073192 DPYSL5 -0.34 -10.24 -0.38 6.78e-23 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs2404602 0.647 rs11632765 chr15:76974261 A/T cg23625390 chr15:77176239 SCAPER 0.54 13.99 0.48 5.71e-39 Blood metabolite levels; BRCA cis rs7520050 0.966 rs6680380 chr1:46300189 T/G cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.43e-21 Red blood cell count;Reticulocyte count; BRCA trans rs2832077 1.000 rs12329875 chr21:30137796 C/T cg14791747 chr16:20752902 THUMPD1 0.4 9.51 0.35 3.8e-20 Cognitive test performance; BRCA cis rs56104184 0.775 rs55756106 chr19:49403055 A/G cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs6752107 0.935 rs10929326 chr2:234151045 T/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 10.9 0.4 1.74e-25 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2795502 1.000 rs2185717 chr10:43343875 G/A cg20628663 chr10:43360327 NA 0.7 13.53 0.47 7.1e-37 Blood protein levels; BRCA cis rs7103648 0.966 rs874896 chr11:47418953 C/G cg03711944 chr11:47377212 SPI1 -0.42 -11.53 -0.41 4.54e-28 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs10782582 0.593 rs79552201 chr1:76215497 A/T cg03433033 chr1:76189801 ACADM -0.49 -10.43 -0.38 1.28e-23 Daytime sleep phenotypes; BRCA cis rs2732480 0.577 rs2732466 chr12:48732459 A/G cg04545296 chr12:48745243 ZNF641 0.25 8.21 0.31 1.25e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs2712184 0.721 rs2541401 chr2:217641006 T/C cg05032264 chr2:217675019 NA -0.38 -9.13 -0.34 9.04e-19 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs9790314 0.521 rs13084746 chr3:161086038 G/A cg04691961 chr3:161091175 C3orf57 -0.46 -10.85 -0.39 2.66e-25 Morning vs. evening chronotype; BRCA cis rs3008870 0.785 rs10889651 chr1:67463513 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.62 -13.5 -0.47 9.64e-37 Lymphocyte percentage of white cells; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg18402987 chr7:1209562 NA 0.47 9.9 0.36 1.4e-21 Longevity;Endometriosis; BRCA cis rs6088813 0.885 rs6142353 chr20:33942685 G/A cg14752227 chr20:34000481 UQCC -0.43 -9.16 -0.34 6.86e-19 Height; BRCA cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg10802521 chr3:52805072 NEK4 -0.32 -8.33 -0.31 4.93e-16 Bipolar disorder; BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg03354898 chr7:1950403 MAD1L1 -0.46 -9.47 -0.35 5.41e-20 Bipolar disorder and schizophrenia; BRCA cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg14784868 chr12:69753453 YEATS4 -0.55 -13.91 -0.48 1.25e-38 Blood protein levels; BRCA cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA cis rs478222 1.000 rs551573 chr2:25305504 A/G cg01884057 chr2:25150051 NA 0.31 8.17 0.31 1.7e-15 Type 1 diabetes; BRCA cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg03433033 chr1:76189801 ACADM 0.86 22.28 0.66 8.17e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg13010199 chr12:38710504 ALG10B -0.38 -8.75 -0.33 1.88e-17 Morning vs. evening chronotype; BRCA cis rs2832077 0.689 rs2832055 chr21:30132382 C/G cg24692254 chr21:30365293 RNF160 0.45 9.53 0.35 3.17e-20 Cognitive test performance; BRCA cis rs698833 0.506 rs4952705 chr2:44499867 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.73 0.33 2.26e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs10242455 0.557 rs2404487 chr7:99038057 G/A cg09045935 chr12:6379348 NA 0.84 8.26 0.31 8.16e-16 Blood metabolite levels; BRCA cis rs10911232 0.507 rs10797816 chr1:182998486 A/T ch.1.3577855R chr1:183094577 LAMC1 0.6 15.43 0.52 6.55e-46 Hypertriglyceridemia; BRCA cis rs4481887 1.000 rs11204626 chr1:248458974 T/A cg00666640 chr1:248458726 OR2T12 0.33 8.55 0.32 9.4e-17 Common traits (Other); BRCA cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg20701182 chr2:24300061 SF3B14 0.66 9.09 0.34 1.18e-18 Lymphocyte counts; BRCA cis rs1401999 1.000 rs2872249 chr3:183636273 T/A cg01324343 chr3:183735012 ABCC5 0.85 21.59 0.65 4.58e-78 Anterior chamber depth; BRCA cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg24110177 chr3:50126178 RBM5 0.51 14.4 0.5 6.06e-41 Body mass index; BRCA cis rs1371614 0.632 rs4665363 chr2:27156416 T/G cg00617064 chr2:27272375 NA 0.31 8.02 0.3 5.14e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.48 -10.95 -0.4 1.08e-25 Bipolar disorder; BRCA cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg12437481 chr16:420112 MRPL28 -0.39 -8.63 -0.32 5.01e-17 Bone mineral density (spine);Bone mineral density; BRCA cis rs8016982 0.674 rs8004096 chr14:81701082 T/G cg01989461 chr14:81687754 GTF2A1 0.62 14.47 0.5 2.86e-41 Schizophrenia; BRCA cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg05340658 chr4:99064831 C4orf37 0.61 14.11 0.49 1.47e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg25767906 chr1:53392781 SCP2 0.37 8.6 0.32 6.07e-17 Monocyte count; BRCA cis rs11098499 0.754 rs4443261 chr4:120249301 T/C cg09307838 chr4:120376055 NA 0.64 14.0 0.48 5.12e-39 Corneal astigmatism; BRCA trans rs9858542 0.953 rs9862080 chr3:49674458 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.42 -10.24 -0.38 7.06e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2481665 0.617 rs12732781 chr1:62518459 T/C cg18591186 chr1:62594603 INADL -0.39 -8.47 -0.32 1.74e-16 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9467773 0.620 rs1027204 chr6:26639613 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs4955485 chr3:134295843 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.34 -0.61 6.06e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11039216 1 rs11039216 chr11:47406592 C/T cg20307385 chr11:47447363 PSMC3 0.57 14.09 0.49 1.86e-39 Neuroticism; BRCA cis rs2070433 0.539 rs1008549 chr21:47959698 C/T cg12379764 chr21:47803548 PCNT 0.56 11.82 0.42 2.83e-29 Lymphocyte counts; BRCA cis rs1555322 0.505 rs639763 chr20:33861904 C/T cg17927777 chr20:33865990 NA 0.46 8.41 0.32 2.71e-16 Attention deficit hyperactivity disorder; BRCA cis rs7766436 0.648 rs7757111 chr6:22591154 C/A cg13666174 chr6:22585274 NA -0.43 -10.77 -0.39 5.81e-25 Coronary artery disease; BRCA cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.59e-23 Motion sickness; BRCA cis rs490234 0.841 rs13285366 chr9:128375047 G/A cg14078157 chr9:128172775 NA -0.47 -10.7 -0.39 1.05e-24 Mean arterial pressure; BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.79 -12.89 -0.45 5.78e-34 Platelet count; BRCA cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg26343298 chr8:95960752 TP53INP1 0.3 8.74 0.33 2.07e-17 Type 2 diabetes; BRCA cis rs7772486 0.902 rs1331643 chr6:146398873 T/A cg23711669 chr6:146136114 FBXO30 0.66 15.51 0.52 2.73e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs244731 1.000 rs244730 chr5:176539212 A/G cg06060754 chr5:176797920 RGS14 -0.67 -10.85 -0.39 2.65e-25 Urate levels in lean individuals; BRCA cis rs6484504 0.652 rs494464 chr11:31386150 C/T cg26647111 chr11:31128758 NA 0.43 9.53 0.35 3.18e-20 Red blood cell count; BRCA cis rs6878727 0.665 rs698179 chr5:123668072 C/A cg01806427 chr5:123737813 NA -0.36 -8.21 -0.31 1.24e-15 Breast cancer; BRCA cis rs6831352 0.819 rs1230155 chr4:99989259 C/T cg12011299 chr4:100065546 ADH4 0.39 9.37 0.35 1.26e-19 Alcohol dependence; BRCA cis rs546131 0.820 rs744841 chr11:34857667 G/A cg06937548 chr11:34938143 PDHX;APIP 0.5 9.7 0.36 7.59e-21 Lung disease severity in cystic fibrosis; BRCA cis rs6433895 0.677 rs11688120 chr2:181997950 T/C cg00481216 chr2:181971175 NA 0.46 8.68 0.32 3.35e-17 Lymphocyte counts; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg23708337 chr7:1209742 NA 0.64 8.93 0.33 4.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7582720 1.000 rs72934563 chr2:203995405 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.75 0.45 2.48e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.45 -8.44 -0.32 2.12e-16 Gut microbiome composition (summer); BRCA trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.91 -0.3 1.14e-14 Corneal astigmatism; BRCA cis rs523522 0.962 rs4766969 chr12:120988238 A/G cg12219531 chr12:120966889 COQ5 0.53 11.26 0.41 5.91e-27 High light scatter reticulocyte count; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg24846343 chr22:24311635 DDTL 0.56 14.54 0.5 1.34e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.59 12.07 0.43 2.33e-30 Tonsillectomy; BRCA cis rs10496034 1.000 rs77602473 chr2:55184781 A/C cg16098955 chr2:55172992 EML6 0.52 9.2 0.34 5.07e-19 Refractive astigmatism; BRCA cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg04450456 chr4:17643702 FAM184B 0.35 9.6 0.35 1.82e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6446731 0.517 rs2858086 chr4:3270611 A/G cg08886695 chr4:3369023 RGS12 0.37 9.87 0.36 1.82e-21 Mean platelet volume; BRCA cis rs7258465 1.000 rs8103622 chr19:18572834 C/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.73 -0.33 2.23e-17 Breast cancer; BRCA cis rs1468333 1.000 rs62381795 chr5:137577870 G/T cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.22 0.34 4.3e-19 Resting heart rate; BRCA cis rs9790314 0.846 rs899275 chr3:161042104 T/C cg03342759 chr3:160939853 NMD3 -0.73 -18.46 -0.59 2.61e-61 Morning vs. evening chronotype; BRCA cis rs17095355 1.000 rs7080576 chr10:111710817 C/T cg00817464 chr10:111662876 XPNPEP1 0.37 9.71 0.36 6.89e-21 Biliary atresia; BRCA cis rs9392556 0.829 rs633290 chr6:4114788 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 0.37 8.19 0.31 1.4e-15 Blood metabolite levels; BRCA cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg09035930 chr12:129282057 SLC15A4 -0.52 -15.8 -0.53 9.91e-48 Systemic lupus erythematosus; BRCA cis rs17270561 0.666 rs4711099 chr6:25741809 C/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -12.28 -0.44 2.89e-31 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.62e-22 Bladder cancer; BRCA cis rs9814567 0.806 rs2293293 chr3:134322742 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.82 -0.55 7.94e-53 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.29 -0.49 2.04e-40 Hemoglobin concentration; BRCA cis rs7789940 0.951 rs73140055 chr7:75975777 A/T cg10167463 chr7:75959203 YWHAG -0.44 -8.72 -0.33 2.34e-17 Multiple sclerosis; BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg23285459 chr7:2802560 GNA12 -0.34 -8.34 -0.31 4.73e-16 Height; BRCA cis rs7647973 1.000 rs9842132 chr3:49427933 G/A cg07636037 chr3:49044803 WDR6 -0.73 -15.9 -0.53 3.45e-48 Menarche (age at onset); BRCA cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA trans rs1459104 1.000 rs66654577 chr11:55168539 G/A cg15704280 chr7:45808275 SEPT13 0.63 8.0 0.3 5.74e-15 Body mass index; BRCA cis rs875971 0.862 rs801209 chr7:66019390 G/T cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA cis rs4889855 0.530 rs8079792 chr17:78609394 A/G cg16591659 chr17:78472290 NA -0.31 -8.0 -0.3 6.06e-15 Fractional excretion of uric acid; BRCA cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg10802521 chr3:52805072 NEK4 0.32 8.34 0.31 4.52e-16 Bipolar disorder; BRCA cis rs751728 0.626 rs6457741 chr6:33756026 C/T cg25922239 chr6:33757077 LEMD2 0.49 12.55 0.44 1.92e-32 Crohn's disease; BRCA cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg14196790 chr5:131705035 SLC22A5 0.32 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs870825 0.550 rs10000507 chr4:185619281 C/T cg04058563 chr4:185651563 MLF1IP 0.76 17.0 0.56 1e-53 Blood protein levels; BRCA cis rs9403521 1.000 rs116980222 chr6:143998987 C/T cg18240653 chr6:144019428 PHACTR2 -0.41 -8.18 -0.31 1.5e-15 Obesity-related traits; BRCA cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg23029597 chr12:123009494 RSRC2 0.62 11.99 0.43 4.88e-30 Body mass index; BRCA cis rs4363385 0.747 rs946099 chr1:152971618 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.35 -0.35 1.47e-19 Inflammatory skin disease; BRCA cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg19539972 chr4:7069911 GRPEL1 0.69 16.89 0.56 3.38e-53 Monocyte percentage of white cells; BRCA cis rs2806561 0.964 rs1757041 chr1:23506063 G/A cg19743168 chr1:23544995 NA 0.41 9.92 0.37 1.14e-21 Height; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg07092213 chr7:1199455 ZFAND2A -0.5 -10.94 -0.4 1.21e-25 Longevity;Endometriosis; BRCA trans rs12310956 0.515 rs11052934 chr12:33970381 T/C cg26384229 chr12:38710491 ALG10B 0.47 10.39 0.38 1.73e-23 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs2424700 chr20:25266513 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.83 0.36 2.48e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8028182 0.636 rs10152155 chr15:75701554 A/T cg20655648 chr15:75932815 IMP3 0.42 8.27 0.31 7.82e-16 Sudden cardiac arrest; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg16590910 chr6:42928470 GNMT 0.41 9.17 0.34 6.58e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg14820908 chr5:178986412 RUFY1 0.49 12.99 0.46 2.11e-34 Lung cancer; BRCA cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg05340658 chr4:99064831 C4orf37 0.66 15.53 0.52 2.29e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.74 0.39 7.59e-25 Cognitive ability; BRCA trans rs11722228 0.508 rs2241473 chr4:10085949 G/A cg26043149 chr18:55253948 FECH 1.05 22.5 0.66 5.15e-83 Gout;Urate levels;Serum uric acid levels; BRCA cis rs6089584 0.566 rs55881457 chr20:60608424 G/A cg06108461 chr20:60628389 TAF4 -0.72 -15.04 -0.51 5.71e-44 Body mass index; BRCA cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg24692254 chr21:30365293 RNF160 -0.79 -21.88 -0.65 1.3e-79 Dental caries; BRCA cis rs796364 1.000 rs166845 chr2:200823360 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.81 13.5 0.47 9.75e-37 Schizophrenia; BRCA cis rs524281 0.648 rs10896089 chr11:65936292 A/G cg16950941 chr11:66035639 RAB1B -0.37 -7.83 -0.3 2e-14 Electroencephalogram traits; BRCA cis rs12618769 0.597 rs3754885 chr2:99121708 G/T cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 21.99 0.66 3.34e-80 Chronic sinus infection; BRCA cis rs736408 0.677 rs678 chr3:52820981 A/T cg10802521 chr3:52805072 NEK4 -0.32 -8.08 -0.3 3.26e-15 Bipolar disorder; BRCA cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg00071950 chr4:10020882 SLC2A9 0.66 16.62 0.55 7.62e-52 Bone mineral density; BRCA cis rs4853036 1.000 rs28362672 chr2:70056866 A/G cg02498382 chr2:70120550 SNRNP27 -0.51 -9.27 -0.34 2.72e-19 Colorectal or endometrial cancer; BRCA cis rs7178424 0.875 rs8029942 chr15:62353458 G/A cg00456672 chr15:62358751 C2CD4A -0.36 -8.58 -0.32 7.3e-17 Height; BRCA cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.66 -0.32 3.7e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6910061 0.830 rs9468435 chr6:11112486 G/A cg27233058 chr6:11094804 LOC221710 0.5 8.51 0.32 1.21e-16 Diabetic kidney disease; BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg23285459 chr7:2802560 GNA12 0.35 8.95 0.33 3.85e-18 Height; BRCA cis rs4141404 0.561 rs5994376 chr22:31563555 A/C cg02404636 chr22:31891804 SFI1 -0.35 -8.42 -0.32 2.46e-16 Paclitaxel-induced neuropathy; BRCA cis rs7408868 1.000 rs10406754 chr19:15274201 T/A cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg25237894 chr2:233734115 C2orf82 0.38 10.98 0.4 7.87e-26 Coronary artery disease; BRCA cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg27624424 chr6:160112604 SOD2 0.39 8.23 0.31 1.02e-15 Age-related macular degeneration (geographic atrophy); BRCA cis rs4660306 1.000 rs2356559 chr1:45981512 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.38 -7.95 -0.3 8.41e-15 Homocysteine levels; BRCA cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg19257562 chr1:2043853 PRKCZ -0.32 -8.86 -0.33 7.62e-18 Height; BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg11814155 chr7:99998594 ZCWPW1 0.57 9.69 0.36 7.98e-21 Platelet count; BRCA cis rs7246657 0.722 rs2972437 chr19:38210511 G/T cg14683738 chr19:37701593 ZNF585B 0.46 7.82 0.3 2.11e-14 Coronary artery calcification; BRCA cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg11752832 chr7:134001865 SLC35B4 0.39 9.65 0.36 1.21e-20 Mean platelet volume; BRCA cis rs2953174 0.507 rs2953172 chr2:241525316 C/T cg07929629 chr2:241523174 NA 0.57 10.92 0.4 1.43e-25 Bipolar disorder; BRCA cis rs514406 0.668 rs520281 chr1:53365235 G/C cg01802117 chr1:53393560 SCP2 -0.42 -9.43 -0.35 7.5599999999999994e-20 Monocyte count; BRCA cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg11764359 chr7:65958608 NA -0.76 -17.18 -0.56 1.11e-54 Aortic root size; BRCA cis rs7582180 0.614 rs4149518 chr2:101013649 A/G cg08017756 chr2:100939284 LONRF2 -0.3 -7.89 -0.3 1.36e-14 Intelligence (multi-trait analysis); BRCA cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg13628971 chr7:2884303 GNA12 0.6 13.49 0.47 1.16e-36 Height; BRCA cis rs7927771 0.524 rs6485773 chr11:47763509 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs1448094 0.512 rs11832992 chr12:86240790 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.22 -0.34 4.11e-19 Major depressive disorder; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg18765753 chr7:1198926 ZFAND2A -0.41 -10.09 -0.37 2.59e-22 Longevity;Endometriosis; BRCA cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg24531977 chr5:56204891 C5orf35 -0.88 -18.15 -0.58 1.15e-59 Initial pursuit acceleration; BRCA cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.03 0.49 3.57e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg04944784 chr2:26401820 FAM59B -0.9 -16.49 -0.55 3.51e-51 Gut microbiome composition (summer); BRCA cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.47 0.38 9.14e-24 Motion sickness; BRCA trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.09 0.34 1.28e-18 Morning vs. evening chronotype; BRCA cis rs4660306 1.000 rs2356561 chr1:45980862 T/G cg24296786 chr1:45957014 TESK2 0.43 9.08 0.34 1.33e-18 Homocysteine levels; BRCA cis rs867371 0.929 rs7173852 chr15:82461853 A/G cg00614314 chr15:82944287 LOC80154 0.42 8.88 0.33 6.72e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.21 0.56 7.75e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg20701182 chr2:24300061 SF3B14 0.66 9.65 0.36 1.15e-20 Lymphocyte counts; BRCA cis rs6973256 0.865 rs11771373 chr7:133334842 A/G cg07491979 chr7:133331646 EXOC4 -0.39 -8.91 -0.33 5.11e-18 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.534 rs4931770 chr12:34044479 G/T cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.85e-20 Morning vs. evening chronotype; BRCA cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg12927641 chr6:109611667 NA -0.36 -8.97 -0.33 3.21e-18 Reticulocyte fraction of red cells; BRCA cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.72e-15 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg17063962 chr7:91808500 NA 0.54 12.26 0.44 3.63e-31 Breast cancer; BRCA cis rs17401966 0.931 rs10492972 chr1:10353112 A/G cg03954927 chr1:10346856 KIF1B 0.47 14.9 0.51 2.49e-43 Hepatocellular carcinoma; BRCA cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg06634786 chr22:41940651 POLR3H 0.5 9.13 0.34 9.23e-19 Vitiligo; BRCA cis rs4319547 0.695 rs7301515 chr12:122949673 T/C cg23029597 chr12:123009494 RSRC2 -0.63 -11.3 -0.41 3.87e-27 Body mass index; BRCA cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.9e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs936229 0.690 rs2472299 chr15:75033400 C/T cg14664628 chr15:75095509 CSK 0.84 22.56 0.67 2.58e-83 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg01579765 chr21:45077557 HSF2BP -0.44 -11.84 -0.42 2.26e-29 Mean corpuscular volume; BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.41 -0.35 8.6e-20 Total body bone mineral density; BRCA cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg11812906 chr14:75593930 NEK9 -0.56 -12.63 -0.45 8.23e-33 Height; BRCA cis rs67981189 0.892 rs221899 chr14:71605268 C/T cg15816911 chr14:71606274 NA 0.36 8.13 0.31 2.19e-15 Schizophrenia; BRCA cis rs9487051 0.676 rs11964178 chr6:109562035 A/G cg21918786 chr6:109611834 NA -0.31 -8.07 -0.3 3.38e-15 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg01483505 chr11:975446 AP2A2 0.34 9.21 0.34 4.73e-19 Alzheimer's disease (late onset); BRCA cis rs9473147 0.543 rs9369716 chr6:47552180 A/T cg12968598 chr6:47444699 CD2AP 0.46 9.84 0.36 2.34e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.6 0.39 2.62e-24 Chronic sinus infection; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.93e-16 Total body bone mineral density; BRCA cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg08085267 chr17:45401833 C17orf57 -0.64 -13.75 -0.48 7.46e-38 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7131987 0.675 rs2194515 chr12:29550383 T/C cg09582351 chr12:29534625 ERGIC2 0.4 9.52 0.35 3.5e-20 QT interval; BRCA cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35995292 0.534 rs10274968 chr7:38939254 C/T cg19327137 chr7:38886074 VPS41 0.41 13.47 0.47 1.37e-36 Subjective well-being (multi-trait analysis); BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.72 -15.56 -0.52 1.5e-46 Lymphocyte counts; BRCA cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.64 -11.83 -0.42 2.49e-29 IgG glycosylation; BRCA cis rs12050794 0.671 rs7179427 chr15:72516821 G/A cg16672083 chr15:72433130 SENP8 0.63 14.81 0.51 6.89e-43 Metabolite levels (HVA/MHPG ratio); BRCA cis rs12618769 0.597 rs3769738 chr2:99078367 T/C cg10123293 chr2:99228465 UNC50 0.41 8.27 0.31 8.05e-16 Bipolar disorder; BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.55 8.58 0.32 7.26e-17 Renal function-related traits (BUN); BRCA cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.55 11.56 0.42 3.47e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg25427524 chr10:38739819 LOC399744 -0.71 -17.44 -0.57 5.3e-56 Extrinsic epigenetic age acceleration; BRCA cis rs7633857 0.512 rs2376477 chr3:160700699 G/T cg03342759 chr3:160939853 NMD3 -0.55 -11.66 -0.42 1.32e-28 Educational attainment (years of education); BRCA cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg06627628 chr2:24431161 ITSN2 -0.57 -8.99 -0.34 2.78e-18 Lymphocyte counts; BRCA cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg17691542 chr6:26056736 HIST1H1C 0.52 11.23 0.41 7.91e-27 Height; BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg18230493 chr5:56204884 C5orf35 -0.72 -14.34 -0.49 1.18e-40 Initial pursuit acceleration; BRCA cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.77 -0.42 4.37e-29 Electroencephalogram traits; BRCA cis rs27434 0.583 rs151909 chr5:96156888 T/C cg16492584 chr5:96139282 ERAP1 -0.51 -12.73 -0.45 3.03e-33 Ankylosing spondylitis; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.37 -0.31 3.51e-16 Total body bone mineral density; BRCA cis rs9486719 0.552 rs9399923 chr6:96850379 G/A cg06623918 chr6:96969491 KIAA0776 0.74 15.48 0.52 3.88e-46 Migraine;Coronary artery disease; BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg03709012 chr19:19516395 GATAD2A 0.82 19.29 0.61 1.09e-65 Tonsillectomy; BRCA cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg00074818 chr8:8560427 CLDN23 0.37 8.16 0.31 1.73e-15 Obesity-related traits; BRCA cis rs4481887 1.000 rs4430369 chr1:248464330 A/G cg00666640 chr1:248458726 OR2T12 0.35 9.27 0.34 2.87e-19 Common traits (Other); BRCA cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg05025164 chr4:1340916 KIAA1530 0.36 7.93 0.3 9.59e-15 Longevity; BRCA trans rs3733585 0.699 rs7677710 chr4:9969517 T/G cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 9.34e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11249608 0.636 rs13361077 chr5:178449174 G/C cg21905437 chr5:178450457 ZNF879 0.5 10.61 0.39 2.55e-24 Pubertal anthropometrics; BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg02951883 chr7:2050386 MAD1L1 0.47 11.86 0.42 1.87e-29 Bipolar disorder and schizophrenia; BRCA trans rs7647973 0.626 rs6809879 chr3:49834571 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.38 7.82 0.3 2.2e-14 Menarche (age at onset); BRCA cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg13010199 chr12:38710504 ALG10B -0.49 -10.69 -0.39 1.22e-24 Heart rate; BRCA cis rs4076764 0.846 rs12036398 chr1:163422204 C/T cg24596788 chr1:163392923 NA 0.3 8.04 0.3 4.46e-15 Motion sickness; BRCA cis rs2070488 0.775 rs7644530 chr3:38558316 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.71 -0.53 2.76e-47 Electrocardiographic conduction measures; BRCA cis rs4478858 0.647 rs6425720 chr1:31709555 A/G cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.71e-15 Alcohol dependence; BRCA cis rs1003719 0.788 rs4411798 chr21:38453183 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.56 13.22 0.46 1.93e-35 Eye color traits; BRCA cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg26384229 chr12:38710491 ALG10B -0.64 -16.83 -0.55 7.02e-53 Heart rate; BRCA cis rs17228212 1.000 rs17227883 chr15:67443078 C/T cg26876701 chr15:67458665 SMAD3 -0.47 -9.1 -0.34 1.16e-18 Coronary heart disease; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg14863265 chr7:2801509 GNA12 -0.45 -10.0 -0.37 5.64e-22 Height; BRCA cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg13256891 chr4:100009986 ADH5 0.45 8.03 0.3 4.7e-15 Alcohol dependence; BRCA cis rs6546550 0.901 rs13028508 chr2:70118427 A/T cg02498382 chr2:70120550 SNRNP27 0.52 11.54 0.42 3.9e-28 Prevalent atrial fibrillation; BRCA cis rs1198430 1.000 rs1198431 chr1:23755716 C/T cg19827787 chr1:23763612 ASAP3 -0.36 -9.7 -0.36 7.37e-21 Total cholesterol levels; BRCA cis rs2742234 0.910 rs2503866 chr10:43646261 T/A cg02780029 chr10:43622663 RET -0.4 -10.03 -0.37 4.25e-22 Hirschsprung disease; BRCA cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -12.02 -0.43 3.77e-30 Bipolar disorder; BRCA cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg04455712 chr21:45112962 RRP1B 0.42 10.41 0.38 1.5e-23 Mean corpuscular volume; BRCA cis rs2276314 0.553 rs4799842 chr18:33627968 C/A cg05985134 chr18:33552581 C18orf21 0.42 8.14 0.31 2.09e-15 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs13053817 1.000 rs34305567 chr22:29853562 T/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.49 -8.89 -0.33 6.29e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs708547 0.874 rs73242624 chr4:57847420 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 10.82 0.39 3.69e-25 Response to bleomycin (chromatid breaks); BRCA cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.82e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 13.67 0.48 1.62e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg26116260 chr4:7069785 GRPEL1 -0.86 -17.83 -0.58 5.1e-58 Monocyte percentage of white cells; BRCA cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg24690094 chr11:67383802 NA 0.49 10.57 0.39 3.65e-24 Mean corpuscular volume; BRCA cis rs2011503 0.509 rs11668721 chr19:19760916 G/A cg11584989 chr19:19387371 SF4 0.44 8.5 0.32 1.35e-16 Bipolar disorder; BRCA cis rs7246657 0.722 rs8103647 chr19:38100452 C/A cg23950597 chr19:37808831 NA -0.49 -8.49 -0.32 1.46e-16 Coronary artery calcification; BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg22907277 chr7:1156413 C7orf50 0.4 8.56 0.32 8.34e-17 Longevity;Endometriosis; BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg10729496 chr3:10149963 C3orf24 0.48 8.97 0.33 3.2e-18 Alzheimer's disease; BRCA cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg13319975 chr6:146136371 FBXO30 0.43 10.04 0.37 4.06e-22 Lobe attachment (rater-scored or self-reported); BRCA trans rs3733585 0.631 rs4697707 chr4:10119787 G/T cg26043149 chr18:55253948 FECH -0.4 -8.51 -0.32 1.21e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6430585 0.528 rs309159 chr2:136684940 C/T cg07169764 chr2:136633963 MCM6 1.0 19.2 0.6 3.34e-65 Corneal structure; BRCA cis rs13102973 0.829 rs55951114 chr4:135897925 T/C cg14419869 chr4:135874104 NA 0.48 9.61 0.36 1.69e-20 Subjective well-being; BRCA cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg24642439 chr20:33292090 TP53INP2 0.73 16.99 0.56 1.02e-53 Coronary artery disease; BRCA cis rs11997175 0.819 rs6415400 chr8:33783714 C/T ch.8.33884649F chr8:33765107 NA 0.46 11.41 0.41 1.46e-27 Body mass index; BRCA cis rs9287719 0.967 rs7563816 chr2:10763400 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.87 -0.3 1.52e-14 Prostate cancer; BRCA cis rs7100689 0.622 rs1340383 chr10:82095968 T/G cg00277334 chr10:82204260 NA -0.44 -8.59 -0.32 6.6e-17 Post bronchodilator FEV1; BRCA cis rs936229 1.000 rs4886615 chr15:75131661 A/G cg14664628 chr15:75095509 CSK -0.9 -24.51 -0.7 4.95e-94 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7020830 0.898 rs2790063 chr9:37287405 G/A cg14294708 chr9:37120828 ZCCHC7 1.05 30.81 0.77 1.85e-128 Schizophrenia; BRCA cis rs11792861 0.816 rs17792434 chr9:111667319 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 7.89 0.3 1.31e-14 Menarche (age at onset); BRCA cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.85 0.42 2.03e-29 Lung cancer in ever smokers; BRCA cis rs10465746 0.780 rs1324486 chr1:84384825 A/G cg10977910 chr1:84465055 TTLL7 -0.56 -11.42 -0.41 1.3e-27 Obesity-related traits; BRCA cis rs1348850 0.634 rs2293471 chr2:178487729 T/G cg27490568 chr2:178487706 NA 0.42 7.87 0.3 1.47e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.85 0.36 2.18e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs3733585 0.673 rs6843873 chr4:9958788 A/C cg26043149 chr18:55253948 FECH -0.37 -8.24 -0.31 9.84e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs6479891 1.000 rs10761730 chr10:65017053 C/T cg14819942 chr15:35414228 NA -0.35 -8.57 -0.32 7.85e-17 Arthritis (juvenile idiopathic); BRCA trans rs17685 0.725 rs6947068 chr7:75662056 T/C cg19862616 chr7:65841803 NCRNA00174 -0.85 -27.43 -0.74 4.31e-110 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs35146811 0.735 rs858505 chr7:99819577 G/A cg22906224 chr7:99728672 NA -0.42 -7.82 -0.3 2.27e-14 Coronary artery disease; BRCA cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg26408565 chr15:76604113 ETFA -0.48 -10.23 -0.38 7.71e-23 Blood metabolite levels; BRCA cis rs911119 0.913 rs13043266 chr20:23588127 C/T cg16589663 chr20:23618590 CST3 0.44 8.14 0.31 2.09e-15 Chronic kidney disease; BRCA cis rs6570726 0.935 rs367612 chr6:145828987 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.0 0.51 8.96e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs877282 0.628 rs11253435 chr10:824169 T/C cg15764593 chr10:829463 NA -0.65 -10.7 -0.39 1.04e-24 Uric acid levels; BRCA cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg05279229 chr7:1896384 MAD1L1 -0.39 -8.02 -0.3 5.08e-15 Bipolar disorder and schizophrenia; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18758796 chr5:131593413 PDLIM4 -0.39 -9.49 -0.35 4.59e-20 Acylcarnitine levels; BRCA cis rs887829 0.570 rs4261716 chr2:234593117 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.31 -0.31 5.65e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg03452623 chr4:187889614 NA -0.31 -10.14 -0.37 1.7e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.7 0.39 1.11e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg12573674 chr2:1569213 NA -0.57 -12.43 -0.44 6.56e-32 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs7647973 0.592 rs6774202 chr3:49687779 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -8.11 -0.31 2.53e-15 Menarche (age at onset); BRCA cis rs62103177 0.525 rs10438902 chr18:77745640 A/G cg02751453 chr18:77725136 HSBP1L1 0.38 9.19 0.34 5.6e-19 Opioid sensitivity; BRCA cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg06550200 chr5:1325588 CLPTM1L -0.66 -14.4 -0.49 6.67e-41 Lung cancer; BRCA cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg17143192 chr8:8559678 CLDN23 0.54 10.49 0.38 7.14e-24 Obesity-related traits; BRCA cis rs365132 0.875 rs691141 chr5:176323298 A/G cg16309518 chr5:176445507 NA 0.39 9.51 0.35 3.91e-20 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs4803468 1.000 rs878083 chr19:41897688 G/A cg09537434 chr19:41945824 ATP5SL -0.95 -23.17 -0.68 1.15e-86 Height; BRCA cis rs798554 0.704 rs798512 chr7:2782592 C/G cg04166393 chr7:2884313 GNA12 0.4 8.27 0.31 7.54e-16 Height; BRCA cis rs2860975 0.501 rs602941 chr10:96961184 G/A cg10482532 chr10:96946522 NA -0.55 -13.66 -0.48 1.96e-37 Immune response to smallpox vaccine (IL-6); BRCA cis rs6840360 0.571 rs12648420 chr4:152543434 G/C cg22705602 chr4:152727874 NA -0.32 -8.06 -0.3 3.79e-15 Intelligence (multi-trait analysis); BRCA cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg09658497 chr7:2847517 GNA12 -0.43 -8.54 -0.32 9.92e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg22307029 chr19:49891270 CCDC155 0.54 9.07 0.34 1.4e-18 Multiple sclerosis; BRCA cis rs7147624 1.000 rs11848209 chr14:66022832 T/A cg03016385 chr14:66212404 NA -0.59 -8.96 -0.33 3.61e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs724568 0.546 rs1367458 chr2:67946328 C/T cg17945962 chr2:67939740 NA -0.37 -10.2 -0.37 9.64e-23 Major depressive disorder (broad); BRCA cis rs9467773 1.000 rs9393731 chr6:26529374 C/T cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs7103648 0.932 rs7104036 chr11:47462140 A/G cg20307385 chr11:47447363 PSMC3 0.89 27.06 0.73 4.95e-108 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg21143896 chr7:2802374 GNA12 -0.33 -8.18 -0.31 1.53e-15 Height; BRCA cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg01028140 chr2:1542097 TPO -0.77 -15.42 -0.52 8.12e-46 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4478858 0.684 rs7549343 chr1:31752260 A/G cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs11887277 0.507 rs1821410 chr2:27058507 T/C cg12368169 chr2:27073192 DPYSL5 -0.27 -8.0 -0.3 5.94e-15 Obesity-related traits; BRCA cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg13010199 chr12:38710504 ALG10B 0.54 11.5 0.41 6.2e-28 Heart rate; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.62 -13.14 -0.46 4.52e-35 Lymphocyte counts; BRCA cis rs877529 1.000 rs139413 chr22:39553772 C/T cg12193277 chr22:39547181 CBX7 -0.42 -11.35 -0.41 2.47e-27 Multiple myeloma; BRCA cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg10523679 chr1:76189770 ACADM 0.66 13.76 0.48 6.31e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs290268 0.838 rs290993 chr9:93559572 G/A cg02608019 chr9:93564028 SYK 0.56 12.32 0.44 1.91e-31 Platelet count; BRCA cis rs7975161 0.630 rs4246264 chr12:104637743 C/G cg25273343 chr12:104657179 TXNRD1 -0.61 -9.53 -0.35 3.31e-20 Toenail selenium levels; BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13732083 chr21:47605072 C21orf56 0.38 8.01 0.3 5.6e-15 Testicular germ cell tumor; BRCA cis rs722599 0.748 rs3742783 chr14:75377008 C/T cg08847533 chr14:75593920 NEK9 -0.45 -8.09 -0.3 3.03e-15 IgG glycosylation; BRCA trans rs931812 0.825 rs55818461 chr8:101899229 T/C cg20993868 chr7:22813445 NA 0.58 16.18 0.54 1.26e-49 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg21747090 chr2:27597821 SNX17 -0.4 -8.67 -0.32 3.42e-17 Total body bone mineral density; BRCA cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg24977027 chr2:88469347 THNSL2 -0.45 -10.69 -0.39 1.23e-24 Response to metformin (IC50); BRCA cis rs3820928 0.874 rs10182307 chr2:227875360 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.48 -0.32 1.57e-16 Pulmonary function; BRCA cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.49 -0.32 1.4e-16 Colorectal cancer; BRCA trans rs3857536 0.813 rs2040591 chr6:66945915 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA trans rs7615952 0.608 rs35668111 chr3:125544635 C/T cg07211511 chr3:129823064 LOC729375 -0.78 -15.04 -0.51 5.2e-44 Blood pressure (smoking interaction); BRCA cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg26384229 chr12:38710491 ALG10B 0.86 23.3 0.68 2.11e-87 Heart rate; BRCA cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg05025164 chr4:1340916 KIAA1530 0.76 15.7 0.53 3.33e-47 Longevity; BRCA cis rs6138458 1.000 rs227624 chr20:24911562 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.76 0.7 2.17e-95 Blood protein levels; BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg22920501 chr2:26401640 FAM59B -0.7 -11.81 -0.42 3.01e-29 Gut microbiome composition (summer); BRCA cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg04414720 chr1:150670196 GOLPH3L 0.34 7.82 0.3 2.13e-14 Tonsillectomy; BRCA cis rs11231017 0.507 rs11231058 chr11:62138890 C/T cg23876832 chr11:62092739 NA 0.33 8.23 0.31 1.04e-15 HIV-1 viral setpoint; BRCA cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg16179182 chr5:140090404 VTRNA1-1 0.45 10.7 0.39 1.13e-24 Depressive symptoms (multi-trait analysis); BRCA cis rs8180040 0.764 rs4683324 chr3:47251284 T/C cg27129171 chr3:47204927 SETD2 0.76 19.64 0.61 1.58e-67 Colorectal cancer; BRCA cis rs4803468 0.967 rs4803461 chr19:41908871 G/A cg09537434 chr19:41945824 ATP5SL -0.99 -24.68 -0.7 5.87e-95 Height; BRCA cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs7193541 0.859 rs12598791 chr16:74500745 A/C cg01733217 chr16:74700730 RFWD3 0.63 16.32 0.54 2.76e-50 Multiple myeloma; BRCA cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg07636037 chr3:49044803 WDR6 0.97 29.29 0.76 3.21e-120 Parkinson's disease; BRCA cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg06784218 chr1:46089804 CCDC17 -0.47 -11.08 -0.4 3.29e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9486715 0.809 rs9486467 chr6:96971803 C/T cg06623918 chr6:96969491 KIAA0776 0.92 27.08 0.73 3.74e-108 Headache; BRCA cis rs738322 0.640 rs738321 chr22:38568833 C/G cg25457927 chr22:38595422 NA -0.33 -12.24 -0.44 4.42e-31 Cutaneous nevi; BRCA cis rs701145 0.586 rs181443 chr3:153959028 G/T cg12800244 chr3:153838788 SGEF 0.45 8.92 0.33 4.82e-18 Coronary artery disease; BRCA cis rs3125734 0.633 rs6479792 chr10:63983264 T/G cg09941381 chr10:64027924 RTKN2 -0.27 -8.09 -0.3 3.02e-15 Rheumatoid arthritis; BRCA cis rs8062405 0.929 rs11150609 chr16:28870596 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 4.76e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs1493916 1.000 rs9964702 chr18:31390427 A/C cg15819921 chr19:927150 ARID3A -0.47 -9.01 -0.34 2.3e-18 Life satisfaction; BRCA cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg17971929 chr21:40555470 PSMG1 -0.62 -14.4 -0.49 6.73e-41 Cognitive function; BRCA cis rs4481887 0.927 rs4244185 chr1:248486913 A/G cg00666640 chr1:248458726 OR2T12 0.3 8.58 0.32 7.32e-17 Common traits (Other); BRCA cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg22875332 chr1:76189707 ACADM -0.5 -9.51 -0.35 3.72e-20 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs225245 0.782 rs321599 chr17:33905745 C/T cg19694781 chr19:47549865 TMEM160 -0.32 -7.81 -0.3 2.31e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs1712517 0.873 rs1163083 chr10:105038455 T/A cg05636881 chr10:105038444 INA 0.4 9.06 0.34 1.53e-18 Migraine; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg16590910 chr6:42928470 GNMT 0.42 9.24 0.34 3.62e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg00166722 chr3:10149974 C3orf24 0.65 12.95 0.46 3.08e-34 Alzheimer's disease; BRCA cis rs7727544 0.716 rs6863213 chr5:131575932 C/T cg14196790 chr5:131705035 SLC22A5 0.45 11.57 0.42 3.01e-28 Blood metabolite levels; BRCA cis rs490234 0.812 rs7875713 chr9:128268903 G/T cg14078157 chr9:128172775 NA -0.34 -8.02 -0.3 4.94e-15 Mean arterial pressure; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.36 -8.4 -0.32 2.92e-16 Longevity;Endometriosis; BRCA cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg26597838 chr10:835615 NA 0.82 14.82 0.51 6.49e-43 Eosinophil percentage of granulocytes; BRCA trans rs1973993 0.603 rs1925833 chr1:97023641 C/A cg10631902 chr5:14652156 NA -0.39 -9.99 -0.37 6.45e-22 Weight; BRCA cis rs4363385 0.818 rs2070963 chr1:153004004 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.56 -0.32 8.65e-17 Inflammatory skin disease; BRCA cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg01579765 chr21:45077557 HSF2BP 0.31 8.14 0.31 2.14e-15 Mean corpuscular volume; BRCA trans rs9858542 0.953 rs12330269 chr3:49513910 G/A cg21659725 chr3:3221576 CRBN -0.47 -9.99 -0.37 6.33e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6714710 0.580 rs6711101 chr2:98379813 G/A cg26665480 chr2:98280029 ACTR1B 0.56 13.05 0.46 1.11e-34 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg25173405 chr17:45401733 C17orf57 -0.44 -8.97 -0.33 3.18e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.37 -0.41 2.11e-27 Bipolar disorder; BRCA cis rs2859741 0.565 rs12031540 chr1:37513757 C/T cg09363841 chr1:37513479 NA -0.51 -11.75 -0.42 5.41e-29 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs11083475 0.681 rs62121377 chr19:39257296 G/A cg07403899 chr19:39283540 NA -0.24 -7.89 -0.3 1.33e-14 Heart rate; BRCA cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg05283184 chr6:79620031 NA -0.41 -10.47 -0.38 8.84e-24 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.965 rs7642472 chr3:38525567 T/C cg24069376 chr3:38537580 EXOG 0.43 12.26 0.44 3.42e-31 Electrocardiographic conduction measures; BRCA cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg05623727 chr3:50126028 RBM5 0.42 10.01 0.37 5.4e-22 Intelligence (multi-trait analysis); BRCA cis rs7707921 0.522 rs10065463 chr5:81500280 A/G cg15871215 chr5:81402204 ATG10 -0.37 -9.41 -0.35 8.93e-20 Breast cancer; BRCA cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg04166393 chr7:2884313 GNA12 0.44 9.6 0.35 1.83e-20 Height; BRCA cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg02734326 chr4:10020555 SLC2A9 0.39 8.51 0.32 1.21e-16 Bone mineral density; BRCA cis rs6963495 0.799 rs73190201 chr7:105165891 A/C cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA cis rs7851660 0.935 rs10818124 chr9:100603008 C/T cg13688889 chr9:100608707 NA -0.36 -8.61 -0.32 5.84e-17 Strep throat; BRCA trans rs7824557 0.767 rs7837036 chr8:11175489 A/G cg08975724 chr8:8085496 FLJ10661 0.45 8.22 0.31 1.16e-15 Retinal vascular caliber; BRCA cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg14863265 chr7:2801509 GNA12 -0.42 -8.78 -0.33 1.45e-17 Height; BRCA cis rs965469 1.000 rs8123289 chr20:3253831 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -9.93 -0.37 1e-21 IFN-related cytopenia; BRCA cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg23711669 chr6:146136114 FBXO30 0.8 18.91 0.6 1.06e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs2075371 0.932 rs1862048 chr7:133978167 C/G cg02659138 chr7:134003124 SLC35B4 -0.34 -9.64 -0.36 1.22e-20 Mean platelet volume; BRCA cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg12549451 chr6:135224345 NA -0.36 -8.19 -0.31 1.47e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs2736345 0.516 rs7844858 chr8:11392659 T/A cg15556689 chr8:8085844 FLJ10661 0.34 9.01 0.34 2.28e-18 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.4e-77 Mean platelet volume; BRCA cis rs17095355 1.000 rs12242642 chr10:111724213 G/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.82 -0.36 2.61e-21 Biliary atresia; BRCA trans rs11098499 0.754 rs10212714 chr4:120254302 T/C cg25214090 chr10:38739885 LOC399744 0.46 10.34 0.38 2.86e-23 Corneal astigmatism; BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg00166722 chr3:10149974 C3orf24 0.64 11.27 0.41 5.44e-27 Alzheimer's disease; BRCA cis rs875971 0.662 rs448725 chr7:65514628 A/G cg12463550 chr7:65579703 CRCP 0.37 7.9 0.3 1.23e-14 Aortic root size; BRCA cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg00409905 chr10:38381863 ZNF37A 0.52 11.24 0.41 7.39e-27 Extrinsic epigenetic age acceleration; BRCA cis rs8177253 0.665 rs8177178 chr3:133463272 G/A cg01448562 chr3:133502909 NA -0.43 -9.46 -0.35 5.59e-20 Iron status biomarkers; BRCA trans rs35847492 1.000 rs17730481 chr8:9276163 A/G cg06636001 chr8:8085503 FLJ10661 -0.52 -9.75 -0.36 4.92e-21 Neuroticism; BRCA cis rs1059312 0.932 rs4760593 chr12:129287220 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.36 -0.52 1.57e-45 Systemic lupus erythematosus; BRCA cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg03452623 chr4:187889614 NA -0.35 -11.45 -0.41 9.92e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg27286337 chr10:134555280 INPP5A 0.63 10.7 0.39 1.08e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1448094 0.545 rs11117077 chr12:86277317 A/G cg19622623 chr12:86230825 RASSF9 -0.28 -8.12 -0.31 2.41e-15 Major depressive disorder; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg09177884 chr7:1199841 ZFAND2A 0.43 9.12 0.34 9.78e-19 Longevity;Endometriosis; BRCA cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg05234568 chr11:5960015 NA -0.44 -9.54 -0.35 2.85e-20 DNA methylation (variation); BRCA trans rs10771431 1.000 rs10771431 chr12:9380859 C/T cg27600084 chr12:12264075 NA 0.37 8.66 0.32 3.82e-17 Breast size; BRCA cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -15.85 -0.53 6.05e-48 Chronic sinus infection; BRCA cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg14500267 chr11:67383377 NA 0.4 8.5 0.32 1.33e-16 Mean corpuscular volume; BRCA cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs919433 0.617 rs34632716 chr2:198542619 C/T cg00792783 chr2:198669748 PLCL1 -0.44 -9.64 -0.36 1.24e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs877282 1.000 rs877281 chr10:771557 T/G cg22713356 chr15:30763199 NA 1.31 26.42 0.72 1.6e-104 Uric acid levels; BRCA cis rs7267979 1.000 rs6050547 chr20:25326012 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.56 -0.35 2.51e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg04248312 chr19:17393744 ANKLE1 -0.93 -21.69 -0.65 1.32e-78 Systemic lupus erythematosus; BRCA cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg03161606 chr19:29218774 NA 0.47 8.24 0.31 9.51e-16 Methadone dose in opioid dependence; BRCA trans rs4714291 0.802 rs1923465 chr6:39971376 A/T cg02267698 chr19:7991119 CTXN1 -0.45 -9.41 -0.35 8.5e-20 Strep throat; BRCA cis rs10465746 0.967 rs11163861 chr1:84354282 T/C cg10977910 chr1:84465055 TTLL7 0.51 10.2 0.37 9.92e-23 Obesity-related traits; BRCA cis rs921968 0.541 rs2556391 chr2:219556346 T/C cg02176678 chr2:219576539 TTLL4 -0.5 -12.7 -0.45 4.28e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg21143896 chr7:2802374 GNA12 -0.37 -9.38 -0.35 1.15e-19 Height; BRCA cis rs9807989 0.507 rs4479442 chr2:103054074 A/T cg03938978 chr2:103052716 IL18RAP 0.29 8.5 0.32 1.34e-16 Asthma; BRCA cis rs208515 0.525 rs12193034 chr6:66677866 C/T cg07460842 chr6:66804631 NA 0.87 15.64 0.53 6.69e-47 Exhaled nitric oxide levels; BRCA cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg18016565 chr1:150552671 MCL1 -0.41 -9.43 -0.35 7.2e-20 Tonsillectomy; BRCA cis rs6910061 0.512 rs67794216 chr6:11114209 G/T cg27233058 chr6:11094804 LOC221710 0.54 9.54 0.35 2.87e-20 Diabetic kidney disease; BRCA cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg06115741 chr20:33292138 TP53INP2 0.38 8.47 0.32 1.7e-16 Glomerular filtration rate (creatinine); BRCA cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg10011062 chr15:43941034 CATSPER2 -0.53 -7.81 -0.3 2.27e-14 Lung cancer in ever smokers; BRCA cis rs11105298 0.891 rs10858872 chr12:89872932 C/T cg00757033 chr12:89920650 WDR51B 0.53 10.71 0.39 1.02e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg19257562 chr1:2043853 PRKCZ 0.36 10.5 0.38 6.7e-24 Height; BRCA cis rs4285028 0.948 rs13083557 chr3:121687613 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.88 -0.4 2.15e-25 Multiple sclerosis; BRCA cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.86 -0.33 7.77e-18 Alzheimer's disease (late onset); BRCA cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs16958440 0.867 rs12326221 chr18:44682893 G/T cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg24296786 chr1:45957014 TESK2 0.64 15.96 0.53 1.75e-48 High light scatter reticulocyte count; BRCA cis rs9814567 1.000 rs1357762 chr3:134264859 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.52 -0.61 6.85e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7592578 0.771 rs1128723 chr2:191366707 A/G cg10560079 chr2:191398806 TMEM194B -0.74 -13.38 -0.47 3.5e-36 Diastolic blood pressure; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg04025307 chr7:1156635 C7orf50 0.53 10.45 0.38 1.07e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9486719 1.000 rs11153067 chr6:97039421 A/T cg06623918 chr6:96969491 KIAA0776 0.77 13.47 0.47 1.43e-36 Migraine;Coronary artery disease; BRCA cis rs1005224 0.853 rs6574251 chr14:76136883 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.19 -0.31 1.42e-15 Large artery stroke; BRCA cis rs9287719 0.601 rs12995465 chr2:10716828 G/A cg00105475 chr2:10696890 NA 0.47 10.46 0.38 9.8e-24 Prostate cancer; BRCA cis rs7264396 0.512 rs2425072 chr20:34293686 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -12.05 -0.43 2.69e-30 Total cholesterol levels; BRCA cis rs68170813 0.605 rs4730227 chr7:106904031 G/C cg02696742 chr7:106810147 HBP1 -0.52 -9.03 -0.34 1.96e-18 Coronary artery disease; BRCA cis rs10089 0.953 rs6875982 chr5:127529197 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 13.13 0.46 4.75e-35 Ileal carcinoids; BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg12311346 chr5:56204834 C5orf35 -0.79 -16.01 -0.53 9.84e-49 Initial pursuit acceleration; BRCA trans rs1994135 0.630 rs11052760 chr12:33724949 A/T cg26384229 chr12:38710491 ALG10B 0.6 12.16 0.43 9.04e-31 Resting heart rate; BRCA cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg03433033 chr1:76189801 ACADM 0.86 22.18 0.66 2.75e-81 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4891159 0.724 rs690401 chr18:74108576 C/T cg24786174 chr18:74118243 ZNF516 0.73 17.99 0.58 7.89e-59 Longevity; BRCA cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.92 0.4 1.43e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.954 rs10031665 chr4:120422852 T/C cg09307838 chr4:120376055 NA 0.72 15.33 0.52 2.08e-45 Corneal astigmatism; BRCA cis rs2880765 0.835 rs7178991 chr15:86050944 G/C cg10818794 chr15:86012489 AKAP13 -0.31 -8.85 -0.33 8.84e-18 Coronary artery disease; BRCA cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg02544614 chr20:61657117 NA 0.28 7.93 0.3 1.01e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg11764359 chr7:65958608 NA -0.64 -11.38 -0.41 1.97e-27 Aortic root size; BRCA cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg11279151 chr3:101281821 RG9MTD1 -0.51 -10.58 -0.39 3.13e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg12751644 chr20:60527061 NA 0.4 8.81 0.33 1.16e-17 Obesity-related traits; BRCA cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7777754 0.512 rs11238131 chr7:50538589 T/C cg18232548 chr7:50535776 DDC -0.54 -13.02 -0.46 1.55e-34 Response to zileuton treatment in asthma (FEV1 change interaction); BRCA trans rs1941687 0.527 rs12608181 chr18:31339351 T/G cg27147174 chr7:100797783 AP1S1 -0.4 -8.19 -0.31 1.43e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg19717773 chr7:2847554 GNA12 -0.48 -11.35 -0.41 2.63e-27 Height; BRCA cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg02574844 chr11:5959923 NA -0.4 -7.81 -0.3 2.43e-14 DNA methylation (variation); BRCA trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg23533926 chr12:111358616 MYL2 -0.42 -8.66 -0.32 3.88e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg23711669 chr6:146136114 FBXO30 0.79 18.96 0.6 5.82e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs9463078 0.739 rs6910749 chr6:44773892 A/G cg25276700 chr6:44698697 NA -0.39 -8.99 -0.33 2.87e-18 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg02353165 chr6:42928485 GNMT 0.88 23.62 0.68 3.77e-89 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2070488 1.000 rs7373805 chr3:38455439 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.55 0.61 4.35e-67 Electrocardiographic conduction measures; BRCA cis rs9287719 0.649 rs10929677 chr2:10717548 A/G cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.91e-19 Prostate cancer; BRCA cis rs7617773 0.817 rs9819094 chr3:48319558 C/T cg11946769 chr3:48343235 NME6 0.56 12.02 0.43 3.85e-30 Coronary artery disease; BRCA cis rs10754283 0.967 rs1934044 chr1:90107501 C/T cg21401794 chr1:90099060 LRRC8C -0.48 -11.61 -0.42 2.05e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1401999 0.836 rs34571027 chr3:183726644 T/C cg20387954 chr3:183756860 HTR3D 0.46 10.59 0.39 2.89e-24 Anterior chamber depth; BRCA cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg10523679 chr1:76189770 ACADM -0.75 -15.69 -0.53 3.66e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4663969 0.873 rs759174 chr2:234668245 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.53 -0.32 1.04e-16 Total bilirubin levels in HIV-1 infection; BRCA cis rs7582180 0.629 rs4851296 chr2:100949570 T/C cg14675211 chr2:100938903 LONRF2 0.43 10.0 0.37 5.89e-22 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg21724239 chr8:58056113 NA 0.64 9.9 0.36 1.34e-21 Developmental language disorder (linguistic errors); BRCA cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.14 -0.34 8.3e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg13010199 chr12:38710504 ALG10B 0.35 8.22 0.31 1.1e-15 Drug-induced liver injury (flucloxacillin); BRCA cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg10518543 chr12:38710700 ALG10B 0.36 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg23887609 chr12:130822674 PIWIL1 0.43 9.33 0.35 1.71e-19 Menopause (age at onset); BRCA cis rs12612619 0.732 rs714513 chr2:27206474 T/C cg00617064 chr2:27272375 NA -0.33 -8.63 -0.32 5.03e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg08885076 chr2:99613938 TSGA10 0.51 9.22 0.34 4.18e-19 Chronic sinus infection; BRCA cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.23 0.44 4.9e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1451375 0.698 rs1839740 chr7:50646280 C/T cg18232548 chr7:50535776 DDC 0.39 9.19 0.34 5.5e-19 Malaria; BRCA cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.74e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.567 rs1182190 chr7:2869391 A/G cg19717773 chr7:2847554 GNA12 -0.41 -8.85 -0.33 8.32e-18 Height; BRCA cis rs7662987 0.517 rs4235436 chr4:100039620 G/A cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.06 -0.3 3.89e-15 Menarche (age at onset); BRCA cis rs7766436 0.848 rs66989470 chr6:22598707 G/C cg13666174 chr6:22585274 NA -0.44 -9.56 -0.35 2.43e-20 Coronary artery disease; BRCA cis rs17376456 0.877 rs12109629 chr5:93359702 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.0 0.3 6.07e-15 Diabetic retinopathy; BRCA cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg23711669 chr6:146136114 FBXO30 0.69 15.96 0.53 1.73e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg24642439 chr20:33292090 TP53INP2 0.54 11.63 0.42 1.67e-28 Coronary artery disease; BRCA cis rs3781663 0.526 rs7936612 chr11:70019182 A/G cg06393558 chr11:69982916 ANO1 -0.35 -8.13 -0.31 2.23e-15 Survival in rectal cancer; BRCA cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg06784218 chr1:46089804 CCDC17 0.52 12.34 0.44 1.51e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs270601 0.683 rs81598 chr5:131587960 C/G cg09877947 chr5:131593287 PDLIM4 0.4 9.44 0.35 6.61e-20 Acylcarnitine levels; BRCA cis rs1691799 0.899 rs1168303 chr12:66738586 A/G cg16791601 chr12:66731901 HELB -0.64 -17.29 -0.56 3.01e-55 White blood cell count (basophil); BRCA trans rs3780486 0.846 rs10113903 chr9:33122645 C/G cg04842962 chr6:43655489 MRPS18A -1.1 -36.42 -0.82 4.74e-158 IgG glycosylation; BRCA cis rs72634258 0.554 rs13306061 chr1:7913445 C/T cg00042356 chr1:8021962 PARK7 0.53 8.18 0.31 1.51e-15 Inflammatory bowel disease; BRCA cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs12540874 0.698 rs13234331 chr7:50560314 G/T cg18232548 chr7:50535776 DDC -0.53 -13.45 -0.47 1.7e-36 Systemic sclerosis; BRCA cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5.24e-22 Morning vs. evening chronotype; BRCA cis rs7809950 0.798 rs10281535 chr7:107229618 T/G cg23024343 chr7:107201750 COG5 0.39 8.87 0.33 7.04e-18 Coronary artery disease; BRCA cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg05623727 chr3:50126028 RBM5 -0.43 -10.3 -0.38 3.88e-23 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg11663144 chr21:46675770 NA -0.6 -13.81 -0.48 3.78e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg14019146 chr3:50243930 SLC38A3 0.41 10.05 0.37 3.63e-22 Body mass index; BRCA cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.27 -0.31 8e-16 Bipolar disorder; BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg27170947 chr2:26402098 FAM59B -0.79 -12.79 -0.45 1.7e-33 Gut microbiome composition (summer); BRCA cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg18446336 chr7:2847575 GNA12 -0.34 -8.09 -0.3 3.07e-15 Height; BRCA cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg27446573 chr6:127587934 RNF146 0.91 21.01 0.64 6.71e-75 Breast cancer; BRCA cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg20362242 chr5:692897 TPPP -0.49 -7.85 -0.3 1.72e-14 Obesity-related traits; BRCA cis rs921968 0.541 rs634590 chr2:219372768 C/A cg02176678 chr2:219576539 TTLL4 0.45 11.73 0.42 6.24e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg15145296 chr3:125709740 NA -0.55 -8.65 -0.32 4.23e-17 Blood pressure (smoking interaction); BRCA cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg26384229 chr12:38710491 ALG10B 0.67 15.47 0.52 4.55e-46 Bladder cancer; BRCA cis rs7520050 0.966 rs4660321 chr1:46366760 A/G cg24296786 chr1:45957014 TESK2 0.43 9.85 0.36 2.18e-21 Red blood cell count;Reticulocyte count; BRCA cis rs1451375 0.617 rs7790758 chr7:50561544 G/A cg18232548 chr7:50535776 DDC -0.42 -9.07 -0.34 1.51e-18 Malaria; BRCA cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg22963979 chr7:1858916 MAD1L1 0.4 8.72 0.33 2.39e-17 Bipolar disorder and schizophrenia; BRCA cis rs796364 0.806 rs79725795 chr2:201083534 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -8.15 -0.31 1.86e-15 Schizophrenia; BRCA cis rs17270561 0.609 rs4145216 chr6:25743559 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA trans rs634534 0.563 rs470192 chr11:65724291 C/T cg17712092 chr4:129076599 LARP1B 0.53 12.7 0.45 4.22e-33 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs6842047 0.706 rs4862666 chr4:187136307 A/G cg23442198 chr4:187126114 CYP4V2 0.62 8.49 0.32 1.42e-16 Blood protein levels; BRCA cis rs6460942 1.000 rs6460942 chr7:12420989 T/C cg06484146 chr7:12443880 VWDE -0.6 -8.77 -0.33 1.57e-17 Coronary artery disease; BRCA cis rs3008870 0.755 rs1570838 chr1:67403315 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.13 0.49 1.18e-39 Lymphocyte percentage of white cells; BRCA cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg21143896 chr7:2802374 GNA12 -0.32 -8.08 -0.3 3.22e-15 Height; BRCA cis rs483180 0.512 rs866321 chr1:120224469 T/C cg19096424 chr1:120255104 PHGDH 0.45 10.01 0.37 5.27e-22 Macular telangiectasia type 2; BRCA cis rs9790314 0.846 rs7636941 chr3:160993928 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -10.23 -0.38 7.58e-23 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.07 -0.3 3.52e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17253792 0.822 rs17253730 chr14:56157911 A/G cg01858014 chr14:56050164 KTN1 -0.76 -9.54 -0.35 3.02e-20 Putamen volume; BRCA cis rs58785573 0.504 rs62294474 chr4:38628725 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.49 10.39 0.38 1.75e-23 Lymphocyte percentage of white cells; BRCA cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg02527881 chr3:46936655 PTH1R 0.35 8.23 0.31 1.09e-15 Birth weight; BRCA cis rs10504073 0.584 rs1511365 chr8:49975321 A/T cg00325661 chr8:49890786 NA 0.48 13.76 0.48 6.64e-38 Blood metabolite ratios; BRCA cis rs208520 0.690 rs12198745 chr6:66722598 T/C cg07460842 chr6:66804631 NA 0.93 18.53 0.59 1.17e-61 Exhaled nitric oxide output; BRCA cis rs2625529 0.526 rs11634622 chr15:72562327 G/A cg16672083 chr15:72433130 SENP8 0.61 14.64 0.5 4.47e-42 Red blood cell count; BRCA cis rs4268898 0.931 rs7603997 chr2:24524958 C/T cg06627628 chr2:24431161 ITSN2 -0.51 -10.37 -0.38 2.19e-23 Asthma; BRCA cis rs35110281 0.627 rs7282704 chr21:44966253 A/G cg21573476 chr21:45109991 RRP1B -0.34 -8.72 -0.33 2.34e-17 Mean corpuscular volume; BRCA cis rs7512552 0.839 rs11577600 chr1:150407443 G/A cg15654264 chr1:150340011 RPRD2 0.41 8.87 0.33 7.38e-18 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg10578991 chr7:12443926 VWDE -0.54 -7.96 -0.3 7.88e-15 Coronary artery disease; BRCA cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg04455712 chr21:45112962 RRP1B 0.42 10.54 0.38 4.45e-24 Mean corpuscular volume; BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg02353165 chr6:42928485 GNMT -0.89 -23.18 -0.68 1e-86 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs8072100 0.935 rs78551919 chr17:45626002 A/C cg08085267 chr17:45401833 C17orf57 0.67 15.0 0.51 8.13e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6963495 0.818 rs56177071 chr7:105165648 C/T cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10819733 chr22:24237672 NA 0.34 9.26 0.34 3.16e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg17063962 chr7:91808500 NA 0.61 14.54 0.5 1.46e-41 Breast cancer; BRCA cis rs9308433 0.529 rs4655336 chr1:214499667 A/C cg06198575 chr1:214491504 SMYD2 0.56 12.32 0.44 2e-31 IgG glycosylation; BRCA cis rs11764590 0.694 rs6977161 chr7:2099361 T/C cg23422044 chr7:1970798 MAD1L1 -0.45 -9.53 -0.35 3.34e-20 Neuroticism; BRCA cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg26384229 chr12:38710491 ALG10B 0.75 17.2 0.56 8.96e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg11764359 chr7:65958608 NA -0.74 -16.09 -0.54 3.77e-49 Aortic root size; BRCA cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.92 0.74 9.27e-113 Chronic sinus infection; BRCA cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg06552810 chr11:31128660 NA 0.37 8.58 0.32 7.41e-17 Red blood cell count; BRCA cis rs7894051 1.000 rs7074435 chr10:135190570 G/T cg20534287 chr10:135191450 PAOX 0.58 9.75 0.36 5.13e-21 Lifespan; BRCA trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg15704280 chr7:45808275 SEPT13 -0.49 -9.64 -0.36 1.29e-20 HDL cholesterol; BRCA cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg04102894 chr7:1000210 NA -0.36 -8.56 -0.32 8.32e-17 Bronchopulmonary dysplasia; BRCA cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg08999081 chr20:33150536 PIGU 0.46 12.96 0.46 2.82e-34 Glomerular filtration rate (creatinine); BRCA cis rs7927771 0.864 rs755555 chr11:47431966 C/T cg20307385 chr11:47447363 PSMC3 -0.42 -8.61 -0.32 5.68e-17 Subjective well-being; BRCA cis rs1971762 0.563 rs3897117 chr12:54077407 T/G cg23533419 chr12:54090519 NA -0.33 -8.3 -0.31 6.23e-16 Height; BRCA cis rs875971 0.825 rs801202 chr7:66023929 C/T cg18876405 chr7:65276391 NA -0.5 -11.04 -0.4 4.74e-26 Aortic root size; BRCA cis rs17102884 0.506 rs4899541 chr14:75403437 T/G cg08847533 chr14:75593920 NEK9 -0.47 -9.39 -0.35 1.01e-19 Neuroticism; BRCA cis rs2882667 0.654 rs4835704 chr5:138151325 G/A cg04439458 chr5:138467593 SIL1 0.35 8.47 0.32 1.63e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs490234 0.702 rs13287071 chr9:128268224 T/C cg14078157 chr9:128172775 NA -0.55 -11.96 -0.43 6.65e-30 Mean arterial pressure; BRCA cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg25173405 chr17:45401733 C17orf57 -0.53 -11.25 -0.41 6.7e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg18904891 chr8:8559673 CLDN23 0.54 10.46 0.38 9.81e-24 Obesity-related traits; BRCA cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.85 0.42 1.99e-29 Homoarginine levels; BRCA cis rs7598759 0.548 rs6750795 chr2:232378231 T/C cg19187155 chr2:232395269 NMUR1 0.73 17.19 0.56 1.05e-54 Noise-induced hearing loss; BRCA cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg18850127 chr7:39170497 POU6F2 -0.48 -10.79 -0.39 4.63e-25 IgG glycosylation; BRCA cis rs9814567 1.000 rs7645295 chr3:134307734 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.13 -0.34 8.78e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg03929089 chr4:120376271 NA 0.49 8.21 0.31 1.24e-15 Axial length; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 14.73 0.5 1.72e-42 Platelet count; BRCA cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg17892150 chr10:133769511 PPP2R2D -0.72 -15.05 -0.51 4.84e-44 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg02503808 chr4:7069936 GRPEL1 -0.8 -17.93 -0.58 1.55e-58 Monocyte percentage of white cells; BRCA cis rs72781680 0.752 rs55801864 chr2:23922325 C/T cg08917208 chr2:24149416 ATAD2B 1.06 14.37 0.49 8.94e-41 Lymphocyte counts; BRCA cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg06026331 chr20:60912101 LAMA5 0.39 7.82 0.3 2.25e-14 Colorectal cancer; BRCA cis rs6964587 0.869 rs55811257 chr7:91484799 T/A cg17063962 chr7:91808500 NA -0.51 -11.93 -0.43 9.13e-30 Breast cancer; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg04518342 chr5:131593106 PDLIM4 0.42 10.1 0.37 2.41e-22 Acylcarnitine levels; BRCA cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg13770153 chr20:60521292 NA -0.43 -9.51 -0.35 3.76e-20 Body mass index; BRCA cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg19678392 chr7:94953810 PON1 -0.41 -8.88 -0.33 6.78e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs858239 0.600 rs6978827 chr7:23125544 A/T cg23682824 chr7:23144976 KLHL7 0.45 12.23 0.44 4.63e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 1.01e-15 Axial length; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg21782813 chr7:2030301 MAD1L1 0.33 8.8 0.33 1.31e-17 Bipolar disorder and schizophrenia; BRCA cis rs56399783 0.901 rs17132744 chr7:2874982 T/C cg19731401 chr7:2775893 GNA12 0.52 8.47 0.32 1.63e-16 Childhood ear infection; BRCA cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg20701182 chr2:24300061 SF3B14 0.57 8.67 0.32 3.66e-17 Lymphocyte counts; BRCA cis rs17270561 0.583 rs7749149 chr6:25781139 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 9.34 0.35 1.53e-19 Iron status biomarkers; BRCA cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg18225595 chr11:63971243 STIP1 0.53 9.82 0.36 2.77e-21 Mean platelet volume; BRCA cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg00277334 chr10:82204260 NA -0.85 -25.05 -0.7 5.02e-97 Post bronchodilator FEV1; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg18765753 chr7:1198926 ZFAND2A -0.41 -8.18 -0.31 1.5e-15 Bronchopulmonary dysplasia; BRCA cis rs7677751 0.806 rs4864861 chr4:55097685 C/T cg17187183 chr4:55093834 PDGFRA 0.45 8.9 0.33 5.87e-18 Corneal astigmatism; BRCA trans rs7178375 1.000 rs35162264 chr15:31200683 T/A cg04373760 chr16:53404718 NA 0.47 8.81 0.33 1.21e-17 Hypertriglyceridemia; BRCA cis rs17270561 0.609 rs9358887 chr6:25759406 G/T cg16482183 chr6:26056742 HIST1H1C 0.51 9.91 0.36 1.27e-21 Iron status biomarkers; BRCA cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg15605315 chr1:45957053 TESK2 0.47 9.77 0.36 4.19e-21 High light scatter reticulocyte count; BRCA cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg23711669 chr6:146136114 FBXO30 0.77 17.73 0.57 1.74e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs11608355 0.515 rs11611011 chr12:109936948 C/T cg05360138 chr12:110035743 NA 0.74 13.68 0.48 1.56e-37 Neuroticism; BRCA cis rs11792861 0.890 rs3087979 chr9:111781779 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 7.97 0.3 7.41e-15 Menarche (age at onset); BRCA cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg18479299 chr3:125709523 NA -0.52 -8.63 -0.32 4.83e-17 Blood pressure (smoking interaction); BRCA cis rs9880211 0.800 rs34324561 chr3:136101242 T/G cg21827317 chr3:136751795 NA -0.44 -7.98 -0.3 6.98e-15 Body mass index;Height; BRCA cis rs56399783 0.901 rs73047387 chr7:2774125 G/A cg19731401 chr7:2775893 GNA12 0.56 8.63 0.32 4.69e-17 Childhood ear infection; BRCA trans rs826838 0.654 rs7977738 chr12:38722460 G/A cg23762105 chr12:34175262 ALG10 -0.38 -9.61 -0.36 1.62e-20 Heart rate; BRCA cis rs6723226 0.572 rs176411 chr2:32643528 A/G cg02381751 chr2:32503542 YIPF4 0.44 9.46 0.35 5.68e-20 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.967 rs720501 chr2:227778445 C/T cg11843606 chr2:227700838 RHBDD1 -0.39 -8.65 -0.32 4.08e-17 Pulmonary function; BRCA trans rs3733585 0.726 rs4306953 chr4:9955776 G/A cg26043149 chr18:55253948 FECH -0.37 -8.3 -0.31 6.41e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2204008 0.777 rs11179774 chr12:38219559 A/C cg06521331 chr12:34319734 NA -0.54 -9.78 -0.36 3.7e-21 Bladder cancer; BRCA cis rs1577917 0.629 rs7761762 chr6:86205968 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.3 8.23 0.31 1.05e-15 Response to antipsychotic treatment; BRCA trans rs2204008 0.744 rs11514071 chr12:38392076 C/T cg06521331 chr12:34319734 NA -0.46 -8.38 -0.31 3.31e-16 Bladder cancer; BRCA cis rs6882046 0.533 rs599402 chr5:88043656 G/C cg22951263 chr5:87985283 NA -0.39 -10.87 -0.4 2.19e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs634534 0.622 rs552130 chr11:65732800 T/C cg26695010 chr11:65641043 EFEMP2 -0.34 -7.98 -0.3 6.64e-15 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs61931739 0.500 rs7977194 chr12:34408459 G/A cg06521331 chr12:34319734 NA -0.56 -9.94 -0.37 9.53e-22 Morning vs. evening chronotype; BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg22920501 chr2:26401640 FAM59B -0.9 -16.71 -0.55 2.92e-52 Gut microbiome composition (summer); BRCA cis rs897080 0.589 rs1067380 chr2:44646834 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.61 0.36 1.64e-20 Height; BRCA cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg11764359 chr7:65958608 NA 0.59 10.36 0.38 2.3e-23 Aortic root size; BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg00106254 chr7:1943704 MAD1L1 -0.44 -11.89 -0.43 1.31e-29 Bipolar disorder and schizophrenia; BRCA cis rs7617773 0.694 rs13099560 chr3:48204768 C/T cg11946769 chr3:48343235 NME6 -0.5 -11.14 -0.4 1.86e-26 Coronary artery disease; BRCA cis rs2629540 0.766 rs10794177 chr10:126407409 G/C cg08799069 chr10:126477246 METTL10 0.46 9.35 0.35 1.4e-19 Cocaine dependence; BRCA cis rs2430307 0.556 rs3905501 chr7:76542080 C/T cg05843312 chr7:76586131 NA -0.48 -8.55 -0.32 8.97e-17 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg23711669 chr6:146136114 FBXO30 0.84 20.17 0.62 2.1e-70 Lobe attachment (rater-scored or self-reported); BRCA cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg07507251 chr3:52567010 NT5DC2 0.35 7.95 0.3 8.35e-15 Electroencephalogram traits; BRCA cis rs2806561 0.704 rs588387 chr1:23523689 A/G cg19743168 chr1:23544995 NA 0.35 8.15 0.31 1.89e-15 Height; BRCA cis rs6598955 0.671 rs17163749 chr1:26568165 A/G cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 3.08e-15 Obesity-related traits; BRCA cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg06115741 chr20:33292138 TP53INP2 0.5 11.11 0.4 2.49e-26 Coronary artery disease; BRCA cis rs9435341 1.000 rs9435341 chr1:107616641 T/C cg09367891 chr1:107599246 PRMT6 -0.43 -8.46 -0.32 1.84e-16 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs6977660 0.714 rs10252965 chr7:19822385 A/C cg07541023 chr7:19748670 TWISTNB 0.53 9.27 0.34 2.77e-19 Thyroid stimulating hormone; BRCA cis rs2479724 0.846 rs2251084 chr6:41838119 T/C cg17623882 chr6:41773611 USP49 -0.34 -9.13 -0.34 8.98e-19 Menarche (age at onset); BRCA cis rs7246657 0.722 rs2075284 chr19:38189616 T/C cg23950597 chr19:37808831 NA 0.51 8.56 0.32 8.59e-17 Coronary artery calcification; BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg00814883 chr7:100076585 TSC22D4 -0.54 -11.37 -0.41 1.98e-27 Platelet count; BRCA cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg26031613 chr14:104095156 KLC1 0.72 15.64 0.53 6.49e-47 Body mass index; BRCA trans rs9858542 0.953 rs9859556 chr3:49455986 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.17 -0.34 6.34e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg24450063 chr1:156163899 SLC25A44 0.91 17.64 0.57 5.11e-57 Testicular germ cell tumor; BRCA cis rs992157 0.775 rs7559428 chr2:219150238 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.2 -0.4 1.08e-26 Colorectal cancer; BRCA cis rs208346 0.612 rs208356 chr7:2775825 A/T cg09658497 chr7:2847517 GNA12 0.51 10.34 0.38 2.7e-23 Loneliness (linear analysis); BRCA cis rs4268898 0.662 rs2288074 chr2:24413595 C/T cg06627628 chr2:24431161 ITSN2 -0.82 -14.82 -0.51 6.31e-43 Asthma; BRCA cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg20701182 chr2:24300061 SF3B14 0.55 8.51 0.32 1.21e-16 Lymphocyte counts; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg05863683 chr7:1912471 MAD1L1 0.38 7.82 0.3 2.21e-14 Bipolar disorder and schizophrenia; BRCA cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.63 0.61 1.6e-67 Cognitive function; BRCA trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg20587970 chr11:113659929 NA -0.89 -16.5 -0.55 3.42e-51 Hip circumference adjusted for BMI; BRCA cis rs13102973 0.899 rs4546304 chr4:135902382 G/A cg14419869 chr4:135874104 NA 0.46 9.22 0.34 4.42e-19 Subjective well-being; BRCA cis rs7635838 0.596 rs13353463 chr3:11260221 T/C cg00170343 chr3:11313890 ATG7 0.4 8.17 0.31 1.61e-15 HDL cholesterol; BRCA cis rs9487051 0.737 rs1260593 chr6:109521400 C/T cg21918786 chr6:109611834 NA -0.35 -9.24 -0.34 3.73e-19 Reticulocyte fraction of red cells; BRCA cis rs4930561 0.714 rs7126326 chr11:67947275 T/G cg04465784 chr11:67976953 SUV420H1 -0.27 -8.82 -0.33 1.1e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg23711669 chr6:146136114 FBXO30 0.74 16.82 0.55 7.41e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.43 -0.32 2.23e-16 Total body bone mineral density; BRCA cis rs2777491 0.957 rs3743038 chr15:41694743 C/T cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.96 -0.53 1.59e-48 Ulcerative colitis; BRCA cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.48e-61 Cognitive function; BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs6089829 1.000 rs62207535 chr20:61669187 A/G cg08045932 chr20:61659980 NA 0.48 10.67 0.39 1.47e-24 Prostate cancer (SNP x SNP interaction); BRCA cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03264133 chr6:25882463 NA 0.52 10.8 0.39 4.52e-25 Intelligence (multi-trait analysis); BRCA cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg10295955 chr4:187884368 NA -0.93 -26.99 -0.73 1.23e-107 Lobe attachment (rater-scored or self-reported); BRCA cis rs908922 0.676 rs1337338 chr1:152511885 G/A cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA cis rs3771570 0.681 rs12151655 chr2:242281438 T/A cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs3892630 0.824 rs34748593 chr19:33240447 T/C cg22980127 chr19:33182716 NUDT19 0.9 17.6 0.57 7.68e-57 Red blood cell traits; BRCA cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg08859206 chr1:53392774 SCP2 0.45 9.94 0.37 9.63e-22 Monocyte count; BRCA cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg24450063 chr1:156163899 SLC25A44 1.08 33.86 0.8 9.84e-145 Testicular germ cell tumor; BRCA cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.03 0.34 1.96e-18 Motion sickness; BRCA cis rs6570726 0.935 rs390252 chr6:145856896 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.89 0.51 2.93e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs2688608 0.592 rs11000758 chr10:75493610 A/T cg23231163 chr10:75533350 FUT11 -0.33 -8.78 -0.33 1.48e-17 Inflammatory bowel disease; BRCA cis rs877282 0.583 rs112372193 chr10:826602 A/G cg15764593 chr10:829463 NA -0.65 -10.71 -0.39 1.02e-24 Uric acid levels; BRCA cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.79 19.25 0.61 1.83e-65 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs589448 0.902 rs315124 chr12:69771727 G/A cg20891283 chr12:69753455 YEATS4 0.83 28.58 0.75 2.23e-116 Cerebrospinal fluid biomarker levels; BRCA cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.61 13.0 0.46 1.99e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs9815354 0.812 rs73830532 chr3:41898814 T/C cg03022575 chr3:42003672 ULK4 0.71 9.71 0.36 7.25e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg16414030 chr3:133502952 NA -0.47 -11.22 -0.41 8.72e-27 Iron status biomarkers; BRCA cis rs7123876 0.504 rs1157343 chr11:72429141 A/G cg04827223 chr11:72435913 ARAP1 0.51 13.23 0.46 1.66e-35 Body mass index; BRCA cis rs2625529 0.730 rs1481861 chr15:72240129 A/G cg16672083 chr15:72433130 SENP8 0.71 16.5 0.55 3.25e-51 Red blood cell count; BRCA cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg18876405 chr7:65276391 NA -0.55 -13.42 -0.47 2.26e-36 Aortic root size; BRCA cis rs34779708 0.931 rs72789609 chr10:35306206 C/T cg03585969 chr10:35415529 CREM 0.55 11.4 0.41 1.62e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs56399783 0.901 rs7803944 chr7:2809087 G/A cg19731401 chr7:2775893 GNA12 0.47 8.13 0.31 2.26e-15 Childhood ear infection; BRCA cis rs4690686 0.500 rs12498564 chr4:177264827 T/C cg17059388 chr4:177262070 NA 0.51 10.75 0.39 6.89e-25 Essential tremor; BRCA cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.98 -0.3 6.79e-15 Bipolar disorder; BRCA cis rs9527 0.590 rs12785223 chr10:104844011 C/T cg04362960 chr10:104952993 NT5C2 -0.44 -10.05 -0.37 3.68e-22 Arsenic metabolism; BRCA cis rs9309473 0.948 rs10183818 chr2:73714556 A/G cg20560298 chr2:73613845 ALMS1 -0.5 -12.11 -0.43 1.57e-30 Metabolite levels; BRCA cis rs514406 0.505 rs437954 chr1:53173321 C/G cg24675658 chr1:53192096 ZYG11B -0.66 -14.52 -0.5 1.76e-41 Monocyte count; BRCA cis rs41005 1.000 rs41004 chr2:8111580 C/T cg03155496 chr2:8117019 LOC339788 0.57 15.32 0.52 2.26e-45 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs2249625 0.523 rs2496554 chr6:72855840 A/T cg18830697 chr6:72922368 RIMS1 -0.51 -11.54 -0.42 4.16e-28 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs10254118 0.757 rs13241123 chr7:133135507 A/T cg10665199 chr7:133106180 EXOC4 0.47 9.53 0.35 3.15e-20 Intelligence (multi-trait analysis); BRCA cis rs3784262 1.000 rs12903474 chr15:58276747 A/C cg12031962 chr15:58353849 ALDH1A2 0.48 12.69 0.45 4.49e-33 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs75804782 0.630 rs74404946 chr2:239300772 C/G cg01134436 chr17:81009848 B3GNTL1 0.76 8.18 0.31 1.48e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs9467773 1.000 rs9393731 chr6:26529374 C/T cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg13628971 chr7:2884303 GNA12 0.37 7.97 0.3 7.3e-15 Height; BRCA cis rs11190604 1.000 rs11190578 chr10:102238953 C/T cg07080220 chr10:102295463 HIF1AN 0.51 11.37 0.41 2.08e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs637571 0.522 rs679581 chr11:65746653 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.5 0.35 4.06e-20 Eosinophil percentage of white cells; BRCA cis rs9527 0.615 rs9733635 chr10:104711940 G/A cg04362960 chr10:104952993 NT5C2 0.46 10.56 0.39 3.89e-24 Arsenic metabolism; BRCA cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg26898376 chr11:64110657 CCDC88B 0.36 7.86 0.3 1.69e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg06671706 chr8:8559999 CLDN23 0.46 8.83 0.33 1.02e-17 Obesity-related traits; BRCA cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg20887711 chr4:1340912 KIAA1530 0.36 8.66 0.32 3.8e-17 Longevity; BRCA cis rs12134245 0.527 rs6681073 chr1:92022597 A/C cg25838465 chr1:92012736 NA -0.38 -8.54 -0.32 9.54e-17 Breast cancer; BRCA cis rs875971 1.000 rs697970 chr7:65560052 G/C cg11764359 chr7:65958608 NA -0.77 -17.76 -0.57 1.21e-57 Aortic root size; BRCA cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg13395646 chr4:1353034 KIAA1530 -0.52 -9.3 -0.35 2.25e-19 Obesity-related traits; BRCA cis rs10754283 0.967 rs10801763 chr1:90120822 C/T cg21401794 chr1:90099060 LRRC8C 0.47 11.61 0.42 2.01e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.34 0.38 2.79e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs73142122 chr7:65311298 C/A cg18252515 chr7:66147081 NA -0.87 -12.08 -0.43 2.13e-30 Diabetic kidney disease; BRCA cis rs17641971 0.708 rs4873303 chr8:49922675 G/A cg00325661 chr8:49890786 NA 0.35 9.59 0.35 1.98e-20 Blood metabolite levels; BRCA cis rs7598759 0.548 rs11693738 chr2:232360484 C/T cg19187155 chr2:232395269 NMUR1 0.7 16.94 0.56 1.96e-53 Noise-induced hearing loss; BRCA cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg26446133 chr18:72167187 CNDP2 -0.78 -14.37 -0.49 8.43e-41 Refractive error; BRCA cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg26818010 chr10:134567672 INPP5A -0.78 -15.17 -0.51 1.27e-44 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg21770322 chr7:97807741 LMTK2 -0.37 -9.79 -0.36 3.62e-21 Prostate cancer (SNP x SNP interaction); BRCA trans rs9291683 0.632 rs12508991 chr4:10041104 C/T cg26043149 chr18:55253948 FECH 0.43 9.17 0.34 6.33e-19 Bone mineral density; BRCA cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg22974920 chr21:40686053 BRWD1 -0.34 -7.86 -0.3 1.59e-14 Menarche (age at onset); BRCA cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg19748678 chr4:122722346 EXOSC9 0.74 16.02 0.54 8.68e-49 Type 2 diabetes; BRCA cis rs1003719 0.788 rs61701101 chr21:38450317 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.24e-40 Eye color traits; BRCA cis rs2046867 0.818 rs6786469 chr3:72873809 A/G cg25664220 chr3:72788482 NA -0.54 -11.66 -0.42 1.28e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs7613875 0.600 rs2624848 chr3:50165101 T/C cg14019146 chr3:50243930 SLC38A3 0.4 9.71 0.36 7.01e-21 Body mass index; BRCA cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.58 0.39 3.15e-24 Motion sickness; BRCA cis rs7246657 0.943 rs7252346 chr19:37914682 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA trans rs11098499 0.644 rs3806808 chr4:120551085 A/C cg25214090 chr10:38739885 LOC399744 0.45 10.1 0.37 2.44e-22 Corneal astigmatism; BRCA cis rs1865760 0.613 rs9379805 chr6:25938764 T/A cg03264133 chr6:25882463 NA -0.37 -8.0 -0.3 5.94e-15 Height; BRCA cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11890956 chr21:40555474 PSMG1 -0.84 -21.73 -0.65 8.47e-79 Cognitive function; BRCA cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg25767906 chr1:53392781 SCP2 0.35 7.92 0.3 1.06e-14 Monocyte count; BRCA cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg21782813 chr7:2030301 MAD1L1 0.37 10.34 0.38 2.84e-23 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg13047869 chr3:10149882 C3orf24 0.53 9.73 0.36 5.63e-21 Alzheimer's disease; BRCA cis rs34779708 0.931 rs1926554 chr10:35344969 C/T cg03585969 chr10:35415529 CREM 0.55 11.41 0.41 1.41e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2066819 1.000 rs78121408 chr12:56684798 C/T cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg11366901 chr6:160182831 ACAT2 0.78 15.03 0.51 5.93e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg12373951 chr3:133503437 NA 0.34 8.11 0.31 2.68e-15 Iron status biomarkers; BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg16606324 chr3:10149918 C3orf24 0.46 7.95 0.3 8.24e-15 Alzheimer's disease; BRCA cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg03433033 chr1:76189801 ACADM -0.47 -9.57 -0.35 2.33e-20 Daytime sleep phenotypes; BRCA cis rs4363385 0.818 rs532773 chr1:153011750 T/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.51e-17 Inflammatory skin disease; BRCA trans rs9291683 0.546 rs13146686 chr4:10034933 A/G cg26043149 chr18:55253948 FECH 0.4 8.78 0.33 1.48e-17 Bone mineral density; BRCA cis rs3741151 0.773 rs57354084 chr11:73139376 A/T cg17517138 chr11:73019481 ARHGEF17 0.89 12.84 0.45 9.44e-34 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs11098499 0.789 rs9991166 chr4:120237851 G/A cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg08280861 chr8:58055591 NA 0.58 8.99 0.33 2.88e-18 Developmental language disorder (linguistic errors); BRCA cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg26384229 chr12:38710491 ALG10B 0.8 20.24 0.62 9.55e-71 Heart rate; BRCA cis rs597539 0.690 rs497149 chr11:68626639 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.42 0.54 7.84e-51 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1348850 0.914 rs1975544 chr2:178465423 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 7.96 0.3 8.08e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg21143896 chr7:2802374 GNA12 -0.38 -9.65 -0.36 1.14e-20 Height; BRCA cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.54 0.5 1.34e-41 Platelet count; BRCA cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs1448094 0.512 rs7308229 chr12:86239849 A/T cg19622623 chr12:86230825 RASSF9 0.33 9.41 0.35 8.68e-20 Major depressive disorder; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.59 -12.29 -0.44 2.48e-31 Lymphocyte counts; BRCA cis rs476633 0.573 rs6492995 chr15:41529712 T/C cg18705301 chr15:41695430 NDUFAF1 -0.52 -11.36 -0.41 2.34e-27 Glomerular filtration rate (creatinine); BRCA cis rs708547 0.541 rs6554392 chr4:57739948 G/A cg16868167 chr4:57843880 C4orf14;POLR2B -0.33 -7.98 -0.3 6.86e-15 Response to bleomycin (chromatid breaks); BRCA trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg08313168 chr12:7315531 NA 0.5 8.09 0.3 2.95e-15 Lung disease severity in cystic fibrosis; BRCA cis rs6460942 0.915 rs10267801 chr7:12451931 G/A cg06484146 chr7:12443880 VWDE -0.55 -8.69 -0.33 2.94e-17 Coronary artery disease; BRCA cis rs36051895 0.659 rs4495487 chr9:5072798 T/C cg02405213 chr9:5042618 JAK2 -0.54 -9.64 -0.36 1.3e-20 Pediatric autoimmune diseases; BRCA cis rs10493773 0.609 rs2389972 chr1:86190666 A/G cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.52 -0.47 8.39e-37 Urate levels in overweight individuals; BRCA cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg02038168 chr22:39784481 NA -0.42 -8.8 -0.33 1.3e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs4566357 0.615 rs12328878 chr2:227918962 G/A cg11843606 chr2:227700838 RHBDD1 -0.44 -9.69 -0.36 8.15e-21 Coronary artery disease; BRCA cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg15145296 chr3:125709740 NA -0.55 -8.7 -0.33 2.73e-17 Blood pressure (smoking interaction); BRCA cis rs9682041 0.561 rs6444928 chr3:170147875 A/G cg11886554 chr3:170076028 SKIL 0.46 8.41 0.32 2.76e-16 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA trans rs35110281 0.715 rs2838320 chr21:44995037 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.16 0.37 1.37e-22 Mean corpuscular volume; BRCA trans rs78049276 0.688 rs61075980 chr4:148374767 G/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.47 -8.01 -0.3 5.47e-15 Pulse pressure; BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg07256732 chr16:621771 PIGQ -0.33 -8.86 -0.33 8e-18 Height; BRCA cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg11833968 chr6:79620685 NA -0.43 -9.55 -0.35 2.75e-20 Intelligence (multi-trait analysis); BRCA cis rs589448 0.902 rs315131 chr12:69761839 T/G cg14784868 chr12:69753453 YEATS4 0.78 24.97 0.7 1.45e-96 Cerebrospinal fluid biomarker levels; BRCA cis rs7727544 0.684 rs274561 chr5:131719228 A/C cg07395648 chr5:131743802 NA -0.41 -10.15 -0.37 1.57e-22 Blood metabolite levels; BRCA cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg20607798 chr8:58055168 NA 0.5 8.58 0.32 7.03e-17 Developmental language disorder (linguistic errors); BRCA cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs11249608 0.548 rs6875622 chr5:178451397 C/T cg21905437 chr5:178450457 ZNF879 0.54 11.32 0.41 3.38e-27 Pubertal anthropometrics; BRCA cis rs919433 0.963 rs10153881 chr2:198171098 T/C cg10820045 chr2:198174542 NA -0.4 -8.65 -0.32 4.06e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6546886 0.912 rs7560668 chr2:74300717 A/G cg14702570 chr2:74259524 NA -0.32 -8.2 -0.31 1.33e-15 Dialysis-related mortality; BRCA trans rs9329221 0.736 rs2001338 chr8:10251217 A/G cg15556689 chr8:8085844 FLJ10661 0.35 8.75 0.33 1.87e-17 Neuroticism; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg16145915 chr7:1198662 ZFAND2A -0.63 -15.13 -0.51 1.98e-44 Longevity;Endometriosis; BRCA cis rs9858542 0.537 rs4410472 chr3:49329090 A/T cg00383909 chr3:49044727 WDR6 0.5 9.77 0.36 4.23e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs17818399 0.510 rs12105801 chr2:46799343 C/G cg02822958 chr2:46747628 ATP6V1E2 0.53 11.05 0.4 4.09e-26 Height; BRCA cis rs6963495 0.818 rs6956234 chr7:105149707 A/G cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.07e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.11 0.4 2.44e-26 Bipolar disorder; BRCA cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12667521 chr19:29218732 NA 0.47 8.68 0.32 3.4e-17 Methadone dose in opioid dependence; BRCA cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.74 11.71 0.42 7.68e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg11941060 chr3:133502564 NA -0.6 -14.9 -0.51 2.59e-43 Iron status biomarkers; BRCA trans rs9944715 0.954 rs4890317 chr18:43770510 A/G cg01718231 chr17:29326311 RNF135 -0.45 -8.73 -0.33 2.18e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs3741404 0.620 rs2236647 chr11:63964605 A/G cg18225595 chr11:63971243 STIP1 -0.4 -9.96 -0.37 7.81e-22 Platelet count; BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg08280861 chr8:58055591 NA 0.56 8.78 0.33 1.49e-17 Developmental language disorder (linguistic errors); BRCA cis rs17209837 0.607 rs12539936 chr7:87110017 A/G cg00919237 chr7:87102261 ABCB4 0.51 9.87 0.36 1.7e-21 Gallbladder cancer; BRCA cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg08917208 chr2:24149416 ATAD2B 0.92 13.6 0.47 3.66e-37 Lymphocyte counts; BRCA cis rs875971 0.651 rs313829 chr7:65552497 A/G cg11764359 chr7:65958608 NA -0.69 -13.28 -0.47 1.04e-35 Aortic root size; BRCA cis rs10924970 0.601 rs2803847 chr1:235503611 C/G cg26050004 chr1:235667680 B3GALNT2 0.36 8.48 0.32 1.58e-16 Asthma; BRCA cis rs12474201 0.928 rs12998762 chr2:46938393 A/C cg06386533 chr2:46925753 SOCS5 0.91 19.84 0.62 1.33e-68 Height; BRCA cis rs561341 1.000 rs484175 chr17:30309041 G/A cg00745463 chr17:30367425 LRRC37B -0.53 -8.87 -0.33 7.27e-18 Hip circumference adjusted for BMI; BRCA cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg10792982 chr14:105748885 BRF1 0.44 10.38 0.38 2.03e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs7267979 0.966 rs2145126 chr20:25263648 G/A cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg21951975 chr1:209979733 IRF6 0.39 8.21 0.31 1.19e-15 Cleft lip with or without cleft palate; BRCA cis rs6910061 0.913 rs28712814 chr6:11108745 T/G cg27233058 chr6:11094804 LOC221710 0.53 9.36 0.35 1.31e-19 Diabetic kidney disease; BRCA cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg23029597 chr12:123009494 RSRC2 -0.6 -11.85 -0.42 1.96e-29 Body mass index; BRCA trans rs867371 0.502 rs3759800 chr15:82532963 A/C cg04831495 chr15:85060580 GOLGA6L5 0.3 8.17 0.31 1.67e-15 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs7914558 0.966 rs10748836 chr10:104693917 G/A cg04362960 chr10:104952993 NT5C2 0.43 10.54 0.38 4.54e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9296092 0.500 rs9469503 chr6:33527234 G/T cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.67 -16.97 -0.56 1.31e-53 Multiple sclerosis; BRCA cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg05340658 chr4:99064831 C4orf37 0.67 16.75 0.55 1.82e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg05623727 chr3:50126028 RBM5 -0.5 -12.14 -0.43 1.17e-30 Body mass index; BRCA cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg07138768 chr7:917805 C7orf20 -0.28 -8.09 -0.3 3.02e-15 Perceived unattractiveness to mosquitoes; BRCA cis rs11608355 0.545 rs4766473 chr12:109900596 C/T cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs875971 0.522 rs56028712 chr7:65466565 C/T cg18876405 chr7:65276391 NA 0.71 18.44 0.59 3.4800000000000003e-61 Aortic root size; BRCA cis rs7301016 0.793 rs11174557 chr12:62979216 C/T cg11441379 chr12:63026424 NA 0.46 8.73 0.33 2.19e-17 IgG glycosylation; BRCA cis rs6840360 0.571 rs718800 chr4:152549307 A/T cg22705602 chr4:152727874 NA 0.32 8.08 0.3 3.2e-15 Intelligence (multi-trait analysis); BRCA cis rs4285028 0.948 rs13089878 chr3:121703895 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.85 -0.39 2.68e-25 Multiple sclerosis; BRCA cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg04455712 chr21:45112962 RRP1B -0.47 -12.92 -0.46 4.4e-34 Mean corpuscular volume; BRCA cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg18357645 chr12:58087776 OS9 0.44 12.52 0.44 2.63e-32 Celiac disease or Rheumatoid arthritis; BRCA cis rs5771069 0.897 rs137858 chr22:50445601 T/C cg03721641 chr22:50451245 IL17REL 0.32 9.93 0.37 1.05e-21 Ulcerative colitis; BRCA cis rs6942756 1.000 rs2012919 chr7:128890812 C/T cg02491457 chr7:128862824 NA -0.7 -13.77 -0.48 5.71e-38 White matter hyperintensity burden; BRCA cis rs36051895 0.659 rs12337134 chr9:5061578 G/A cg02405213 chr9:5042618 JAK2 -0.49 -8.91 -0.33 5.44e-18 Pediatric autoimmune diseases; BRCA cis rs1865760 0.865 rs9467648 chr6:25957933 T/A cg16482183 chr6:26056742 HIST1H1C 0.51 10.58 0.39 3.17e-24 Height; BRCA cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -9.06 -0.34 1.57e-18 Schizophrenia; BRCA cis rs7085104 0.700 rs3740397 chr10:104592675 G/C cg04362960 chr10:104952993 NT5C2 0.39 9.07 0.34 1.45e-18 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.6 9.31 0.35 2e-19 Lung function (FEV1/FVC); BRCA cis rs9611519 0.580 rs7286603 chr22:41440061 T/C cg03806693 chr22:41940476 POLR3H -0.41 -7.81 -0.3 2.29e-14 Neuroticism; BRCA cis rs11711311 1.000 rs13061150 chr3:113506734 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.6 0.32 6.08e-17 IgG glycosylation; BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg25036284 chr2:26402008 FAM59B -0.77 -13.87 -0.48 1.96e-38 Gut microbiome composition (summer); BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg08470875 chr2:26401718 FAM59B 0.58 7.87 0.3 1.5e-14 Gut microbiome composition (summer); BRCA cis rs858239 1.000 rs858240 chr7:23284237 A/G cg23682824 chr7:23144976 KLHL7 0.37 9.14 0.34 8.34e-19 Cerebrospinal fluid biomarker levels; BRCA cis rs2836974 0.863 rs1065242 chr21:40567716 C/G cg17971929 chr21:40555470 PSMG1 0.8 18.85 0.6 2.22e-63 Cognitive function; BRCA cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg19318889 chr4:1322082 MAEA -0.59 -11.92 -0.43 1e-29 Longevity; BRCA cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs7786808 0.712 rs12671981 chr7:158202971 G/A cg02030672 chr11:45687055 CHST1 0.52 11.47 0.41 8.1e-28 Obesity-related traits; BRCA cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.71 -10.41 -0.38 1.5e-23 Schizophrenia; BRCA cis rs12618769 0.625 rs61180742 chr2:99148078 A/G cg10123293 chr2:99228465 UNC50 0.42 8.15 0.31 1.92e-15 Bipolar disorder; BRCA trans rs6582630 0.502 rs11181475 chr12:38348922 G/A cg06521331 chr12:34319734 NA -0.44 -8.35 -0.31 4.37e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg09035930 chr12:129282057 SLC15A4 0.49 13.79 0.48 4.53e-38 Systemic lupus erythematosus; BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg19346786 chr7:2764209 NA -0.31 -9.1 -0.34 1.12e-18 Height; BRCA cis rs870825 0.616 rs12502860 chr4:185636105 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg24803719 chr17:45855879 NA -0.32 -8.47 -0.32 1.75e-16 IgG glycosylation; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg23708337 chr7:1209742 NA 0.37 7.85 0.3 1.74e-14 Longevity;Endometriosis; BRCA cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA trans rs1997103 1.000 rs2331067 chr7:55408232 A/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.64 -0.32 4.45e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2882667 0.587 rs825674 chr5:138102720 A/G cg04439458 chr5:138467593 SIL1 0.37 8.78 0.33 1.5e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 17.25 0.56 4.82e-55 Platelet count; BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg27170947 chr2:26402098 FAM59B -0.65 -11.15 -0.4 1.68e-26 Gut microbiome composition (summer); BRCA cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg24692254 chr21:30365293 RNF160 -0.64 -16.6 -0.55 9.92e-52 Dental caries; BRCA cis rs6433895 0.961 rs6746347 chr2:182017374 T/G cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg05234568 chr11:5960015 NA -0.49 -9.69 -0.36 7.99e-21 DNA methylation (variation); BRCA cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.58 -0.35 2.17e-20 Tonsillectomy; BRCA cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg18876405 chr7:65276391 NA -0.51 -11.68 -0.42 1.02e-28 Aortic root size; BRCA cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.22e-18 Developmental language disorder (linguistic errors); BRCA cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg19628046 chr18:33552617 C18orf21 0.54 11.0 0.4 6.54e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9733 0.744 rs3754211 chr1:150951857 G/A cg13175981 chr1:150552382 MCL1 -0.35 -8.28 -0.31 6.97e-16 Tonsillectomy; BRCA trans rs4714291 0.862 rs2984433 chr6:39973445 T/G cg02267698 chr19:7991119 CTXN1 -0.47 -9.69 -0.36 8.07e-21 Strep throat; BRCA cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg11266682 chr4:10021025 SLC2A9 -0.35 -8.75 -0.33 1.88e-17 Bone mineral density; BRCA cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg23029597 chr12:123009494 RSRC2 -0.65 -12.41 -0.44 7.73e-32 Body mass index; BRCA trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.87 0.3 1.55e-14 Corneal astigmatism; BRCA cis rs9309473 0.607 rs2421488 chr2:73590625 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -12.75 -0.45 2.55e-33 Metabolite levels; BRCA cis rs9815354 0.669 rs113059632 chr3:41932858 G/A cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.71e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2115536 0.606 rs8024713 chr15:80206958 C/G cg00225070 chr15:80189496 MTHFS 0.48 11.5 0.41 5.92e-28 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs10782582 0.586 rs5745383 chr1:76288590 G/C cg03433033 chr1:76189801 ACADM -0.4 -8.18 -0.31 1.52e-15 Daytime sleep phenotypes; BRCA cis rs6138458 1.000 rs6138458 chr20:24973769 C/T cg06937882 chr20:24974362 C20orf3 -0.48 -9.45 -0.35 6.15e-20 Blood protein levels; BRCA cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg03146154 chr1:46216737 IPP -0.45 -9.48 -0.35 4.71e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs28595532 0.623 rs34531766 chr4:119230339 T/C cg21605333 chr4:119757512 SEC24D 0.83 8.78 0.33 1.46e-17 Cannabis dependence symptom count; BRCA cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg04450456 chr4:17643702 FAM184B 0.32 9.41 0.35 8.79e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1538970 0.962 rs2487442 chr1:45857176 C/G cg05343316 chr1:45956843 TESK2 -0.53 -10.98 -0.4 8.58e-26 Platelet count; BRCA cis rs7903847 0.642 rs7092350 chr10:99140218 A/T cg08345082 chr10:99160200 RRP12 -0.29 -8.5 -0.32 1.31e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg12310025 chr6:25882481 NA 0.73 17.74 0.57 1.54e-57 Blood metabolite levels; BRCA cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs9309473 1.000 rs7572722 chr2:73724675 T/C cg20560298 chr2:73613845 ALMS1 -0.44 -10.68 -0.39 1.33e-24 Metabolite levels; BRCA cis rs4076764 1.000 rs6683181 chr1:163417077 C/T cg06092702 chr1:163392909 NA -0.34 -8.81 -0.33 1.21e-17 Motion sickness; BRCA cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg09455208 chr3:40491958 NA -0.39 -9.29 -0.35 2.3e-19 Renal cell carcinoma; BRCA cis rs858239 0.508 rs7805085 chr7:23190243 C/T cg23682824 chr7:23144976 KLHL7 0.37 9.65 0.36 1.12e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs10242455 0.702 rs6974831 chr7:99131605 A/G cg18809830 chr7:99032528 PTCD1 -0.62 -8.73 -0.33 2.23e-17 Blood metabolite levels; BRCA cis rs1707322 1.000 rs34694458 chr1:46332696 G/A cg03146154 chr1:46216737 IPP 0.45 9.98 0.37 6.77e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11890956 chr21:40555474 PSMG1 0.68 15.76 0.53 1.67e-47 Cognitive function; BRCA cis rs870825 0.616 rs7667409 chr4:185650941 C/T cg04058563 chr4:185651563 MLF1IP -0.78 -17.85 -0.58 4.14e-58 Blood protein levels; BRCA trans rs3733585 0.699 rs6856127 chr4:9965443 T/C cg26043149 chr18:55253948 FECH -0.37 -8.27 -0.31 7.64e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs738322 0.600 rs5995542 chr22:38558141 C/T cg25457927 chr22:38595422 NA -0.35 -12.8 -0.45 1.49e-33 Cutaneous nevi; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs72781680 0.660 rs72780104 chr2:23983715 A/G cg08917208 chr2:24149416 ATAD2B 0.9 12.86 0.45 8.23e-34 Lymphocyte counts; BRCA cis rs4363385 0.747 rs6678107 chr1:152966818 T/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.6 -0.35 1.81e-20 Inflammatory skin disease; BRCA cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs4321325 0.733 rs4284778 chr2:127946326 A/G cg11380483 chr2:127933992 NA 0.42 8.16 0.31 1.83e-15 Protein C levels; BRCA cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg13010199 chr12:38710504 ALG10B 0.44 9.57 0.35 2.34e-20 Bladder cancer; BRCA trans rs6582630 0.519 rs8189561 chr12:38296178 G/A cg06521331 chr12:34319734 NA -0.47 -8.69 -0.33 2.99e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs367943 0.608 rs2972662 chr5:112990330 C/T cg12552261 chr5:112820674 MCC -0.37 -8.14 -0.31 2.07e-15 Type 2 diabetes; BRCA cis rs735860 0.726 rs209519 chr6:53208680 G/A cg10236188 chr6:53219634 NA 0.38 7.89 0.3 1.31e-14 Glaucoma; BRCA cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.56 -11.06 -0.4 3.73e-26 Tonsillectomy; BRCA cis rs3768617 0.510 rs12061219 chr1:183101471 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg18016565 chr1:150552671 MCL1 0.35 8.17 0.31 1.62e-15 Tonsillectomy; BRCA cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg14004847 chr7:1930337 MAD1L1 -0.42 -8.4 -0.32 2.98e-16 Bipolar disorder and schizophrenia; BRCA cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg25554036 chr4:6271136 WFS1 -0.36 -8.79 -0.33 1.35e-17 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg25427524 chr10:38739819 LOC399744 -0.64 -14.77 -0.5 1.08e-42 Extrinsic epigenetic age acceleration; BRCA cis rs6570726 0.791 rs6902404 chr6:145905254 G/A cg23711669 chr6:146136114 FBXO30 0.71 16.76 0.55 1.52e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs2073300 0.609 rs6137915 chr20:23358509 A/G cg12062639 chr20:23401060 NAPB -0.88 -12.34 -0.44 1.5e-31 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2066819 1.000 rs41423244 chr12:56693520 A/C cg26714650 chr12:56694279 CS 1.19 15.73 0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs8062405 0.964 rs11864107 chr16:28885931 T/C cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4481887 0.962 rs10788768 chr1:248456027 G/A cg13385794 chr1:248469461 NA 0.29 7.89 0.3 1.34e-14 Common traits (Other); BRCA cis rs6500602 0.793 rs4785964 chr16:4484613 A/G cg08645402 chr16:4508243 NA 0.37 7.89 0.3 1.36e-14 Schizophrenia; BRCA cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg15485101 chr11:133734466 NA 0.41 9.89 0.36 1.51e-21 Childhood ear infection; BRCA cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg21518248 chr2:162101506 NA 0.46 9.59 0.35 1.9e-20 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg20701182 chr2:24300061 SF3B14 0.67 9.75 0.36 4.9e-21 Lymphocyte counts; BRCA cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg26384229 chr12:38710491 ALG10B -0.61 -14.26 -0.49 2.82e-40 Morning vs. evening chronotype; BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg14863265 chr7:2801509 GNA12 -0.46 -10.11 -0.37 2.19e-22 Height; BRCA cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg08917208 chr2:24149416 ATAD2B 1.07 14.82 0.51 5.99e-43 Lymphocyte counts; BRCA cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg24812749 chr6:127587940 RNF146 0.88 20.66 0.63 4.91e-73 Breast cancer; BRCA cis rs782590 0.967 rs6545506 chr2:55798108 A/G cg18811423 chr2:55921094 PNPT1 -0.69 -22.38 -0.66 2.21e-82 Metabolic syndrome; BRCA cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.38 -0.44 1.03e-31 Type 2 diabetes; BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.56 -0.68 8.48e-89 Gut microbiome composition (summer); BRCA cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg15145296 chr3:125709740 NA -0.55 -8.65 -0.32 4.23e-17 Blood pressure (smoking interaction); BRCA trans rs1005277 0.522 rs9418276 chr10:37940116 G/T cg17830980 chr10:43048298 ZNF37B -0.42 -9.58 -0.35 2.18e-20 Extrinsic epigenetic age acceleration; BRCA cis rs4363385 0.818 rs407103 chr1:153007106 C/T cg24667326 chr1:152973720 SPRR3 0.33 9.19 0.34 5.28e-19 Inflammatory skin disease; BRCA cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg16339924 chr4:17578868 LAP3 0.63 15.65 0.53 5.38e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4389656 0.857 rs274709 chr5:6726464 T/C cg10857441 chr5:6722123 POLS -0.25 -7.82 -0.3 2.21e-14 Coronary artery disease; BRCA cis rs7766436 0.813 rs7773580 chr6:22587114 C/T cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA cis rs2011503 1.000 rs11670882 chr19:19649748 C/G cg11584989 chr19:19387371 SF4 0.49 11.05 0.4 4.14e-26 Bipolar disorder; BRCA cis rs6430585 0.697 rs6724569 chr2:136516970 G/A cg07169764 chr2:136633963 MCM6 1.23 25.96 0.72 5.36e-102 Corneal structure; BRCA cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1443512 0.812 rs1975470 chr12:54336841 G/A cg17410650 chr12:54324560 NA -0.43 -10.69 -0.39 1.18e-24 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.65 -11.53 -0.41 4.61e-28 Lung cancer in ever smokers; BRCA cis rs3772130 0.560 rs7649585 chr3:121562300 G/C cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.39 0.49 7.26e-41 Cognitive performance; BRCA cis rs9649213 0.574 rs34817002 chr7:97887051 G/A cg24562669 chr7:97807699 LMTK2 0.47 11.96 0.43 7.09e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg27211696 chr2:191398769 TMEM194B 0.5 11.59 0.42 2.53e-28 Pulse pressure; BRCA cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg07402062 chr16:89894098 SPIRE2 0.26 9.17 0.34 6.54e-19 Vitiligo; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg13047869 chr3:10149882 C3orf24 0.6 12.76 0.45 2.33e-33 Alzheimer's disease; BRCA cis rs13191362 0.507 rs13207363 chr6:163201285 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.46 -8.59 -0.32 6.75e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs68170813 0.559 rs7779062 chr7:106880195 T/A cg02696742 chr7:106810147 HBP1 -0.47 -8.15 -0.31 1.94e-15 Coronary artery disease; BRCA cis rs561341 0.783 rs512698 chr17:30292507 G/T cg12193833 chr17:30244370 NA -0.54 -8.6 -0.32 5.98e-17 Hip circumference adjusted for BMI; BRCA cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12760731 0.565 rs11583144 chr1:178222070 C/G cg00404053 chr1:178313656 RASAL2 0.64 7.83 0.3 2.01e-14 Obesity-related traits; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg27170947 chr2:26402098 FAM59B -0.81 -13.05 -0.46 1.1e-34 Gut microbiome composition (summer); BRCA cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 9.18 0.34 6e-19 Platelet count; BRCA cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg07636037 chr3:49044803 WDR6 0.55 8.7 0.33 2.75e-17 Menarche (age at onset); BRCA cis rs7593730 0.636 rs6743795 chr2:161122134 A/G cg22609984 chr2:161126801 NA 0.43 9.24 0.34 3.68e-19 Type 2 diabetes; BRCA cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.26 8.68 0.32 3.23e-17 Electroencephalogram traits; BRCA cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg03517284 chr6:25882590 NA 0.68 15.76 0.53 1.56e-47 Blood metabolite levels; BRCA cis rs12618769 0.571 rs72821939 chr2:99138872 T/C cg10123293 chr2:99228465 UNC50 0.42 8.1 0.31 2.81e-15 Bipolar disorder; BRCA cis rs634534 0.561 rs14157 chr11:65769780 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 9.82 0.36 2.67e-21 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 17.25 0.56 5.04e-55 Hip circumference adjusted for BMI; BRCA cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg09184832 chr6:79620586 NA -0.51 -11.2 -0.41 1e-26 Intelligence (multi-trait analysis); BRCA cis rs9462027 0.628 rs9462006 chr6:34710327 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA cis rs4908768 0.501 rs12046643 chr1:8547866 A/C cg20416874 chr1:8611966 RERE -0.29 -8.31 -0.31 5.62e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs9287719 0.967 rs6432114 chr2:10744930 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs965469 1.000 rs6051808 chr20:3350697 A/T cg25506879 chr20:3388711 C20orf194 -0.53 -10.45 -0.38 1.06e-23 IFN-related cytopenia; BRCA cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11644478 chr21:40555479 PSMG1 0.73 14.82 0.51 6.06e-43 Cognitive function; BRCA cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg00530320 chr1:46809349 NSUN4 -0.48 -9.75 -0.36 5.01e-21 Menopause (age at onset); BRCA cis rs2280018 0.963 rs11075255 chr16:15166232 A/G cg27102117 chr16:15229624 NA 0.33 7.93 0.3 1.02e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs9308433 0.529 rs6660335 chr1:214501855 C/T cg06198575 chr1:214491504 SMYD2 0.52 11.76 0.42 4.86e-29 IgG glycosylation; BRCA cis rs701145 0.585 rs454837 chr3:153915417 T/C cg17054900 chr3:154042577 DHX36 0.57 9.57 0.35 2.21e-20 Coronary artery disease; BRCA cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg04450456 chr4:17643702 FAM184B 0.37 10.68 0.39 1.3e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4803468 1.000 rs4803465 chr19:41918158 A/G cg09537434 chr19:41945824 ATP5SL 0.98 24.78 0.7 1.67e-95 Height; BRCA cis rs6973256 0.865 rs763646 chr7:133343353 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.03 -0.34 2.04e-18 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.510 rs7542640 chr1:183063738 G/A ch.1.3577855R chr1:183094577 LAMC1 0.68 18.02 0.58 5.02e-59 Fuchs's corneal dystrophy; BRCA cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.54 -0.32 9.87e-17 Bipolar disorder; BRCA cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg00074818 chr8:8560427 CLDN23 0.38 8.4 0.32 2.82e-16 Obesity-related traits; BRCA cis rs1635 0.655 rs58019071 chr6:28304016 T/C cg15743358 chr6:28303923 ZNF323 -0.75 -8.56 -0.32 8.52e-17 Schizophrenia; BRCA cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.44 0.32 2.17e-16 Bone mineral density; BRCA trans rs561341 1.000 rs554078 chr17:30330109 A/C cg27661571 chr11:113659931 NA -0.81 -12.17 -0.43 8.64e-31 Hip circumference adjusted for BMI; BRCA cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.13 0.56 2.04e-54 Bladder cancer; BRCA cis rs3892630 0.878 rs1061686 chr19:33204544 C/T cg22980127 chr19:33182716 NUDT19 -0.9 -17.14 -0.56 1.85e-54 Red blood cell traits; BRCA cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs599083 0.530 rs2472415 chr11:68185616 T/C cg01657329 chr11:68192670 LRP5 0.36 8.08 0.3 3.22e-15 Bone mineral density (spine); BRCA trans rs11098499 0.691 rs9996644 chr4:120238877 G/T cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.36e-23 Corneal astigmatism; BRCA cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg11764359 chr7:65958608 NA 0.62 13.51 0.47 8.75e-37 Calcium levels; BRCA cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.23e-40 Motion sickness; BRCA cis rs7246967 0.551 rs7249473 chr19:22906694 T/C cg23217946 chr19:22817039 ZNF492 0.51 9.31 0.35 1.99e-19 Bronchopulmonary dysplasia; BRCA cis rs6942756 1.000 rs7806089 chr7:128972215 C/G cg02491457 chr7:128862824 NA -0.71 -14.04 -0.49 3.12e-39 White matter hyperintensity burden; BRCA cis rs7523050 0.643 rs34114412 chr1:109402866 C/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs4481887 1.000 rs4244182 chr1:248471174 A/G cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.9e-18 Common traits (Other); BRCA cis rs7715806 0.500 rs4703676 chr5:74979866 G/C cg19683494 chr5:74908142 NA 0.53 8.6 0.32 6.36e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4803468 1.000 rs2241711 chr19:41911980 T/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.54 -0.68 1.1e-88 Height; BRCA cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.47 0.41 7.81e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs77633900 0.614 rs280033 chr15:77023099 G/A cg21673338 chr15:77095150 SCAPER -0.53 -9.72 -0.36 6.2e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs4363385 0.714 rs4845329 chr1:152974454 G/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.33 -0.31 4.93e-16 Inflammatory skin disease; BRCA cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg10820045 chr2:198174542 NA -0.41 -9.36 -0.35 1.28e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs17401966 0.838 rs912963 chr1:10348042 C/T cg03954927 chr1:10346856 KIF1B 0.4 12.65 0.45 7.17e-33 Hepatocellular carcinoma; BRCA cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg04450456 chr4:17643702 FAM184B 0.32 9.32 0.35 1.79e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11190604 1.000 rs10883511 chr10:102299407 A/G cg07080220 chr10:102295463 HIF1AN 0.61 14.38 0.49 7.97e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg08213375 chr14:104286397 PPP1R13B 0.63 17.16 0.56 1.37e-54 Schizophrenia; BRCA cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg27535305 chr1:53392650 SCP2 0.33 8.11 0.31 2.53e-15 Monocyte count; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.66 13.47 0.47 1.37e-36 Lymphocyte counts; BRCA cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg13256891 chr4:100009986 ADH5 0.53 9.79 0.36 3.62e-21 Alcohol dependence; BRCA cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.2 -0.31 1.3e-15 Bipolar disorder; BRCA cis rs919433 0.648 rs787975 chr2:198248128 C/T cg00792783 chr2:198669748 PLCL1 0.37 8.36 0.31 4.04e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg03433033 chr1:76189801 ACADM -0.59 -11.68 -0.42 1.1e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.89 -0.33 6.03e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4268898 1.000 rs4268898 chr2:24490413 C/T cg06627628 chr2:24431161 ITSN2 0.49 10.19 0.37 1.1e-22 Asthma; BRCA cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg26384229 chr12:38710491 ALG10B 0.76 17.14 0.56 1.82e-54 Morning vs. evening chronotype; BRCA cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg06108461 chr20:60628389 TAF4 -1.02 -23.08 -0.67 3.38e-86 Body mass index; BRCA cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg02659138 chr7:134003124 SLC35B4 0.32 9.73 0.36 5.95e-21 Mean platelet volume; BRCA cis rs2243480 1.000 rs313802 chr7:65516373 A/G cg18252515 chr7:66147081 NA -0.97 -13.78 -0.48 5.15e-38 Diabetic kidney disease; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg21747090 chr2:27597821 SNX17 -0.43 -9.44 -0.35 7.04e-20 Total body bone mineral density; BRCA cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg24060327 chr5:131705240 SLC22A5 0.5 10.38 0.38 1.97e-23 Blood metabolite levels; BRCA cis rs1371614 0.611 rs877272 chr2:27139888 C/T cg00617064 chr2:27272375 NA -0.3 -7.93 -0.3 9.74e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg11707556 chr5:10655725 ANKRD33B 0.43 9.58 0.35 2.19e-20 Coronary artery disease; BRCA cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg23711669 chr6:146136114 FBXO30 0.77 17.49 0.57 2.75e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg27279351 chr12:120934652 DYNLL1 0.56 13.31 0.47 7.75e-36 High light scatter reticulocyte count; BRCA cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg20607287 chr7:12443886 VWDE -0.57 -8.03 -0.3 4.78e-15 Coronary artery disease; BRCA cis rs7917772 0.582 rs12784963 chr10:104336986 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.73 -0.48 8.75e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2637266 1.000 rs2579747 chr10:78327759 C/T cg18941641 chr10:78392320 NA 0.36 7.93 0.3 9.78e-15 Pulmonary function; BRCA cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24110177 chr3:50126178 RBM5 -0.36 -9.71 -0.36 6.98e-21 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs13059720 chr3:134242021 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.41 8.61 0.32 5.62e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs644148 0.836 rs2571111 chr19:45000581 C/A cg15540054 chr19:45004280 ZNF180 -0.59 -12.57 -0.45 1.53e-32 Personality dimensions; BRCA trans rs3780486 0.846 rs10738905 chr9:33123627 A/G cg20290983 chr6:43655470 MRPS18A 1.11 40.87 0.85 1.95e-180 IgG glycosylation; BRCA cis rs478304 0.934 rs669742 chr11:65501291 C/T cg08755490 chr11:65554678 OVOL1 0.53 10.96 0.4 9.69e-26 Acne (severe); BRCA cis rs6430585 0.528 rs10496738 chr2:136751488 C/T cg07169764 chr2:136633963 MCM6 1.22 23.75 0.68 7.81e-90 Corneal structure; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg08132940 chr7:1081526 C7orf50 -0.48 -7.85 -0.3 1.78e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6952809 0.532 rs2023969 chr7:2449980 T/C cg23289794 chr7:2394357 EIF3B -0.64 -12.22 -0.44 4.99e-31 Multiple sclerosis; BRCA cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.38e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs34779708 0.733 rs12777960 chr10:35541026 C/A cg03585969 chr10:35415529 CREM 0.45 9.19 0.34 5.29e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg20887711 chr4:1340912 KIAA1530 0.74 15.79 0.53 1.18e-47 Longevity; BRCA cis rs12586317 0.883 rs4982254 chr14:35755737 C/T cg05294307 chr14:35346193 BAZ1A -0.5 -9.12 -0.34 1e-18 Psoriasis; BRCA cis rs7593730 0.551 rs6706685 chr2:161151559 T/C cg22609984 chr2:161126801 NA 0.38 8.25 0.31 8.91e-16 Type 2 diabetes; BRCA cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg24879335 chr3:133465180 TF 0.32 10.94 0.4 1.14e-25 Iron status biomarkers (transferrin levels); BRCA cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.25 0.38 6.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4974559 0.947 rs10000797 chr4:1345647 G/A cg02980000 chr4:1222292 CTBP1 0.76 12.91 0.45 4.7e-34 Systolic blood pressure; BRCA cis rs8028182 0.636 rs8034317 chr15:75764343 G/A cg20655648 chr15:75932815 IMP3 0.41 8.1 0.31 2.81e-15 Sudden cardiac arrest; BRCA cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.05 0.37 3.59e-22 Bladder cancer; BRCA cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg20607798 chr8:58055168 NA -0.52 -8.13 -0.31 2.28e-15 Developmental language disorder (linguistic errors); BRCA cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg13854012 chr2:162103682 NA -0.39 -8.72 -0.33 2.43e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs10501293 1.000 rs10838010 chr11:43122962 T/C cg03447554 chr11:43094025 NA -0.47 -8.57 -0.32 7.95e-17 Cognitive performance; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg04234412 chr22:24373322 LOC391322 -0.82 -23.08 -0.67 3.58e-86 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg25703541 chr22:24373054 LOC391322 0.7 15.83 0.53 7.15e-48 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1595825 0.891 rs16825917 chr2:198805185 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -8.12 -0.31 2.38e-15 Ulcerative colitis; BRCA cis rs4713118 0.662 rs175954 chr6:28011585 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.95 0.3 8.23e-15 Parkinson's disease; BRCA cis rs7666738 0.753 rs28463863 chr4:98844444 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.29 0.49 2.23e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 0.706 rs6460257 chr7:65196780 C/T cg18876405 chr7:65276391 NA 0.53 8.49 0.32 1.42e-16 Diabetic kidney disease; BRCA cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg06002616 chr8:101225028 SPAG1 0.42 10.54 0.38 4.73e-24 Atrioventricular conduction; BRCA cis rs3772130 1.000 rs17691170 chr3:121357626 G/C cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.5 0.35 4.22e-20 Cognitive performance; BRCA cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.17 0.31 1.68e-15 Axial length; BRCA cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg26384229 chr12:38710491 ALG10B 0.72 16.21 0.54 9e-50 Morning vs. evening chronotype; BRCA cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07930192 chr7:1003750 NA 0.48 10.7 0.39 1.04e-24 Longevity;Endometriosis; BRCA cis rs1062753 0.922 rs9611712 chr22:42410993 T/C cg22189786 chr22:42395067 WBP2NL 0.41 8.05 0.3 3.94e-15 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg05340658 chr4:99064831 C4orf37 0.68 17.28 0.56 3.44e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs1003719 0.788 rs2835605 chr21:38490734 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.14 0.49 1.04e-39 Eye color traits; BRCA cis rs9369695 0.881 rs9349409 chr6:47463126 G/T cg12968598 chr6:47444699 CD2AP 0.44 9.7 0.36 7.62e-21 Reticulocyte count; BRCA cis rs4588572 0.644 rs2241566 chr5:77784738 C/T cg11547950 chr5:77652471 NA 0.44 8.34 0.31 4.53e-16 Triglycerides; BRCA cis rs1371614 0.588 rs10181727 chr2:27171245 C/T cg00617064 chr2:27272375 NA 0.31 8.0 0.3 5.86e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg13010199 chr12:38710504 ALG10B 0.35 8.24 0.31 9.47e-16 Morning vs. evening chronotype; BRCA cis rs7772486 0.875 rs2748485 chr6:146332421 T/C cg23711669 chr6:146136114 FBXO30 0.67 15.44 0.52 6.1e-46 Lobe attachment (rater-scored or self-reported); BRCA trans rs2018683 1.000 rs4719962 chr7:28999237 G/A cg19402173 chr7:128379420 CALU -0.6 -15.0 -0.51 8.08e-44 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg10150615 chr22:24372951 LOC391322 0.43 9.4 0.35 9.9e-20 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2239547 0.522 rs6773040 chr3:52935428 C/A cg11645453 chr3:52864694 ITIH4 -0.45 -11.08 -0.4 3.29e-26 Schizophrenia; BRCA cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.27e-41 Motion sickness; BRCA cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg11764359 chr7:65958608 NA -0.68 -15.1 -0.51 2.75e-44 Aortic root size; BRCA cis rs6545883 0.811 rs2921718 chr2:61795267 C/A cg15711740 chr2:61764176 XPO1 -0.56 -14.33 -0.49 1.33e-40 Tuberculosis; BRCA trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg15556689 chr8:8085844 FLJ10661 -0.33 -9.02 -0.34 2.15e-18 Neuroticism; BRCA cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg08999081 chr20:33150536 PIGU -0.43 -12.03 -0.43 3.34e-30 Glomerular filtration rate (creatinine); BRCA cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg24531977 chr5:56204891 C5orf35 0.66 14.48 0.5 2.59e-41 Initial pursuit acceleration; BRCA cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg06064525 chr11:970664 AP2A2 -0.49 -16.2 -0.54 1.01e-49 Alzheimer's disease (late onset); BRCA cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg04673462 chr1:38461896 NA 0.39 7.9 0.3 1.2e-14 Coronary artery disease; BRCA trans rs2197308 0.667 rs61920838 chr12:37856814 T/C cg06521331 chr12:34319734 NA 0.46 9.02 0.34 2.17e-18 Morning vs. evening chronotype; BRCA cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg23583168 chr7:148888333 NA -0.85 -20.03 -0.62 1.24e-69 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg22974920 chr21:40686053 BRWD1 0.39 8.83 0.33 9.89e-18 Cognitive function; BRCA cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.78 0.33 1.45e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs7829975 0.623 rs10092965 chr8:8373485 A/G cg16141378 chr3:129829833 LOC729375 -0.36 -8.78 -0.33 1.52e-17 Mood instability; BRCA trans rs3857536 0.740 rs4710572 chr6:66890361 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.48 -0.35 4.88e-20 Blood trace element (Cu levels); BRCA cis rs6963495 0.818 rs73190133 chr7:105147821 G/C cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.07e-19 Bipolar disorder (body mass index interaction); BRCA cis rs9287719 0.649 rs12618726 chr2:10728375 C/G cg00105475 chr2:10696890 NA 0.41 9.18 0.34 5.88e-19 Prostate cancer; BRCA cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg02733842 chr7:1102375 C7orf50 -0.45 -8.53 -0.32 1.06e-16 Bronchopulmonary dysplasia; BRCA cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg26384229 chr12:38710491 ALG10B 0.65 15.35 0.52 1.64e-45 Drug-induced liver injury (flucloxacillin); BRCA cis rs7927771 0.524 rs10838746 chr11:47706291 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.52 0.35 3.42e-20 Subjective well-being; BRCA cis rs76419734 0.510 rs2553461 chr4:106731410 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.43 -9.39 -0.35 1.01e-19 Post bronchodilator FEV1; BRCA cis rs7246967 0.673 rs16994997 chr19:22879610 T/G cg23217946 chr19:22817039 ZNF492 0.48 8.92 0.33 4.93e-18 Bronchopulmonary dysplasia; BRCA cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg11764359 chr7:65958608 NA 0.78 18.5 0.59 1.63e-61 Aortic root size; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg13880726 chr7:1868755 MAD1L1 0.52 10.45 0.38 1.04e-23 Bipolar disorder and schizophrenia; BRCA trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg21775007 chr8:11205619 TDH -0.41 -8.66 -0.32 3.76e-17 Neuroticism; BRCA cis rs2249625 0.523 rs1969530 chr6:72861276 A/C cg18830697 chr6:72922368 RIMS1 -0.51 -11.46 -0.41 8.64e-28 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA trans rs877282 0.891 rs34652870 chr10:772218 T/C cg22713356 chr15:30763199 NA 1.31 26.42 0.72 1.54e-104 Uric acid levels; BRCA cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg08917208 chr2:24149416 ATAD2B 0.9 12.93 0.46 3.8e-34 Lymphocyte counts; BRCA cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.14e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs1509123 0.609 rs17804635 chr17:6703985 A/G cg12642237 chr17:6703447 TEKT1 0.76 10.52 0.38 5.45e-24 Blood metabolite levels; BRCA cis rs7077164 1.000 rs1227776 chr10:71580893 G/A cg07630274 chr10:71583235 COL13A1 -0.24 -7.92 -0.3 1.05e-14 Non-alcoholic fatty liver disease histology (lobular); BRCA cis rs2742234 0.955 rs1272142 chr10:43695484 G/T cg15436174 chr10:43711423 RASGEF1A -0.4 -8.27 -0.31 7.89e-16 Hirschsprung disease; BRCA cis rs7918232 0.567 rs4749215 chr10:27312005 T/C cg14240646 chr10:27532245 ACBD5 -0.47 -8.18 -0.31 1.55e-15 Breast cancer; BRCA cis rs2072438 0.505 rs7034074 chr9:123923029 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.43 8.99 0.33 2.86e-18 Rheumatoid arthritis; BRCA cis rs9487051 0.766 rs351748 chr6:109532296 C/T cg01475377 chr6:109611718 NA 0.47 11.78 0.42 3.96e-29 Reticulocyte fraction of red cells; BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.34 0.44 1.55e-31 Platelet count; BRCA cis rs11583043 1.000 rs17100939 chr1:101443701 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.4 8.01 0.3 5.58e-15 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg26587870 chr6:27730563 NA -0.39 -8.33 -0.31 5.11e-16 Parkinson's disease; BRCA cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg27478167 chr7:817139 HEATR2 -0.43 -9.13 -0.34 8.64e-19 Cerebrospinal P-tau181p levels; BRCA trans rs1994135 0.715 rs10506110 chr12:33708552 A/C cg26384229 chr12:38710491 ALG10B 0.53 10.79 0.39 4.9e-25 Resting heart rate; BRCA cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg05347473 chr6:146136440 FBXO30 -0.6 -11.36 -0.41 2.22e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs490234 0.676 rs1129 chr9:128199873 A/G cg14078157 chr9:128172775 NA 0.53 11.41 0.41 1.42e-27 Mean arterial pressure; BRCA cis rs6831352 1.000 rs10017466 chr4:100055800 C/T cg12011299 chr4:100065546 ADH4 0.5 13.37 0.47 4.02e-36 Alcohol dependence; BRCA cis rs6424115 0.618 rs10917420 chr1:24062987 C/T cg15997130 chr1:24165203 NA 0.32 7.89 0.3 1.27e-14 Immature fraction of reticulocytes; BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg25036284 chr2:26402008 FAM59B -0.63 -10.46 -0.38 9.54e-24 Gut microbiome composition (summer); BRCA cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg23711669 chr6:146136114 FBXO30 0.71 16.52 0.55 2.73e-51 Lobe attachment (rater-scored or self-reported); BRCA trans rs6952808 1.000 rs4256490 chr7:1890764 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 8.21 0.31 1.19e-15 Bipolar disorder and schizophrenia; BRCA cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg16405210 chr4:1374714 KIAA1530 0.36 8.01 0.3 5.53e-15 Obesity-related traits; BRCA trans rs8073060 0.505 rs225276 chr17:33973034 T/C cg19694781 chr19:47549865 TMEM160 -1.05 -20.96 -0.64 1.16e-74 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1048238 0.506 rs10737911 chr1:16167855 C/T cg21385522 chr1:16154831 NA -0.48 -10.25 -0.38 6.51e-23 Systolic blood pressure; BRCA cis rs7980687 0.662 rs585522 chr12:123550813 A/G cg00376283 chr12:123451042 ABCB9 0.5 11.45 0.41 9.91e-28 Height;Educational attainment;Head circumference (infant); BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.15 -0.31 1.87e-15 Total body bone mineral density; BRCA cis rs6763687 1.000 rs4894796 chr3:171780763 A/G cg16233210 chr3:171778391 FNDC3B 0.45 10.66 0.39 1.63e-24 Red cell distribution width; BRCA cis rs11098499 0.913 rs10006304 chr4:120124305 A/G cg09307838 chr4:120376055 NA 0.61 11.16 0.4 1.57e-26 Corneal astigmatism; BRCA cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg04546413 chr19:29218101 NA 0.64 12.28 0.44 2.81e-31 Methadone dose in opioid dependence; BRCA cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs425277 1.000 rs262667 chr1:2082722 T/C cg00981070 chr1:2046702 PRKCZ 0.31 8.24 0.31 9.76e-16 Height; BRCA cis rs6061231 0.793 rs6061512 chr20:60976929 G/A cg06026331 chr20:60912101 LAMA5 0.44 8.29 0.31 6.94e-16 Colorectal cancer; BRCA cis rs4660306 0.961 rs937290 chr1:45961955 A/G cg24296786 chr1:45957014 TESK2 0.42 8.4 0.32 2.93e-16 Homocysteine levels; BRCA cis rs4862307 0.733 rs28631204 chr4:184996363 T/G cg06737308 chr4:185021514 ENPP6 0.4 8.99 0.34 2.69e-18 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs10540 1.000 rs61876335 chr11:488878 T/C cg15790184 chr11:494944 RNH1 0.6 9.53 0.35 3.09e-20 Body mass index; BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg05863683 chr7:1912471 MAD1L1 0.45 9.98 0.37 7.04e-22 Bipolar disorder and schizophrenia; BRCA cis rs4566357 0.615 rs10177528 chr2:227913706 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -9.0 -0.34 2.51e-18 Coronary artery disease; BRCA trans rs1200821 0.671 rs2226276 chr10:37673052 A/T cg25427524 chr10:38739819 LOC399744 0.38 8.16 0.31 1.81e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12292205 chr6:26970375 C6orf41 -0.47 -8.0 -0.3 5.77e-15 Intelligence (multi-trait analysis); BRCA cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg02175503 chr12:58329896 NA 0.42 8.12 0.31 2.38e-15 Intelligence (multi-trait analysis); BRCA cis rs7582180 0.629 rs12620139 chr2:100943446 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.97 0.43 6.22e-30 Intelligence (multi-trait analysis); BRCA cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg03433033 chr1:76189801 ACADM -0.48 -9.89 -0.36 1.45e-21 Daytime sleep phenotypes; BRCA cis rs17270561 0.609 rs9393659 chr6:25731358 T/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg07930192 chr7:1003750 NA 0.48 10.75 0.39 6.59e-25 Longevity;Endometriosis; BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 8.97 0.33 3.34e-18 Platelet count; BRCA cis rs586533 0.881 rs2458167 chr11:99500748 A/C cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.38e-19 Total body bone mineral density; BRCA trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg15704280 chr7:45808275 SEPT13 -0.53 -10.28 -0.38 4.75e-23 Acute lymphoblastic leukemia (childhood); BRCA trans rs4596713 0.538 rs10869961 chr9:71787071 C/T cg16512924 chr15:28394682 HERC2 0.45 10.86 0.39 2.46e-25 Headache; BRCA cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg11266682 chr4:10021025 SLC2A9 0.46 12.72 0.45 3.4e-33 Bone mineral density; BRCA cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg21361702 chr7:150065534 REPIN1 0.54 9.8 0.36 3.17e-21 Blood protein levels;Circulating chemerin levels; BRCA cis rs6121246 0.657 rs74392247 chr20:30241737 C/T cg13852791 chr20:30311386 BCL2L1 0.76 10.77 0.39 5.5e-25 Mean corpuscular hemoglobin; BRCA cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg06494592 chr3:125709126 NA -0.54 -8.44 -0.32 2.09e-16 Blood pressure (smoking interaction); BRCA cis rs6942756 0.806 rs2566886 chr7:128917866 G/A cg02491457 chr7:128862824 NA 0.56 11.97 0.43 6.22e-30 White matter hyperintensity burden; BRCA cis rs36051895 0.632 rs12684720 chr9:5150800 T/C cg02405213 chr9:5042618 JAK2 -0.44 -8.59 -0.32 6.71e-17 Pediatric autoimmune diseases; BRCA trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg15556689 chr8:8085844 FLJ10661 0.33 9.13 0.34 8.76e-19 Retinal vascular caliber; BRCA cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg08514558 chr10:81106712 PPIF 0.4 9.23 0.34 4e-19 Height; BRCA cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.64e-24 Motion sickness; BRCA cis rs698761 0.519 rs2005202 chr2:44541706 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.45 7.84 0.3 1.91e-14 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.08 0.37 2.77e-22 Bipolar disorder; BRCA cis rs8072100 0.967 rs12452315 chr17:45479446 G/T cg25173405 chr17:45401733 C17orf57 0.54 11.59 0.42 2.41e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12612619 0.732 rs2053385 chr2:27231145 G/A cg00617064 chr2:27272375 NA -0.32 -8.46 -0.32 1.77e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7772486 0.875 rs9403765 chr6:146368041 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -15.16 -0.51 1.45e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg22920501 chr2:26401640 FAM59B -0.9 -16.0 -0.53 1.07e-48 Gut microbiome composition (summer); BRCA trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg00717180 chr2:96193071 NA -0.38 -10.16 -0.37 1.38e-22 HDL cholesterol; BRCA cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -9.79 -0.36 3.47e-21 Monocyte percentage of white cells; BRCA cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -13.01 -0.46 1.76e-34 Developmental language disorder (linguistic errors); BRCA cis rs7095944 0.585 rs11245357 chr10:126452042 A/G cg08799069 chr10:126477246 METTL10 -0.4 -10.16 -0.37 1.43e-22 Asthma; BRCA cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg11905131 chr22:24372483 LOC391322 -0.53 -11.75 -0.42 5.27e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs28830936 1.000 rs9672360 chr15:41912411 T/C cg17847044 chr15:42102381 MAPKBP1 -0.31 -9.02 -0.34 2.24e-18 Diastolic blood pressure; BRCA cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg11764359 chr7:65958608 NA -0.75 -18.0 -0.58 6.97e-59 Aortic root size; BRCA cis rs11190604 1.000 rs11190592 chr10:102291059 T/C cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA trans rs9291683 0.632 rs7679916 chr4:10042160 C/T cg26043149 chr18:55253948 FECH 0.43 9.17 0.34 6.33e-19 Bone mineral density; BRCA cis rs10911232 0.507 rs10797814 chr1:182990929 C/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.88 0.56 3.66e-53 Hypertriglyceridemia; BRCA cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 9.93 0.37 1.03e-21 Tonsillectomy; BRCA cis rs6714710 0.580 rs13032265 chr2:98409565 T/C cg26665480 chr2:98280029 ACTR1B 0.58 13.65 0.48 2.04e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs6542838 0.698 rs7565736 chr2:99464952 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -7.97 -0.3 7.42e-15 Fear of minor pain; BRCA trans rs7819412 0.811 rs2409691 chr8:10943276 C/T cg15556689 chr8:8085844 FLJ10661 -0.4 -10.72 -0.39 8.84e-25 Triglycerides; BRCA cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg22535103 chr8:58192502 C8orf71 -0.6 -13.09 -0.46 7.81e-35 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.67 13.61 0.47 3.12e-37 Lymphocyte counts; BRCA cis rs12431939 1.000 rs55851845 chr14:51645583 A/T cg23942311 chr14:51606299 NA -0.44 -8.34 -0.31 4.53e-16 Cancer; BRCA cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg22875332 chr1:76189707 ACADM 0.81 19.76 0.62 3.25e-68 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2731664 0.792 rs2630765 chr5:176876825 T/C cg23176889 chr5:176863531 GRK6 -0.64 -17.66 -0.57 3.86e-57 Intelligence (multi-trait analysis); BRCA cis rs10028773 0.506 rs12374346 chr4:120281705 G/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Educational attainment; BRCA cis rs3733585 0.605 rs7656624 chr4:10121097 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.33 -0.38 3.17e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.46 0.41 8.48e-28 Personality dimensions; BRCA cis rs10789491 1.000 rs601060 chr1:47139580 C/G cg15501359 chr1:47185051 KIAA0494 -0.65 -18.42 -0.59 4.22e-61 Response to hepatitis C treatment; BRCA cis rs6882046 0.513 rs454214 chr5:88003403 A/G cg22951263 chr5:87985283 NA 0.41 11.14 0.4 1.91e-26 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg01939980 chr4:1354348 KIAA1530 0.38 8.8 0.33 1.24e-17 Obesity-related traits; BRCA cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg27478167 chr7:817139 HEATR2 -0.56 -11.13 -0.4 2.03e-26 Cerebrospinal P-tau181p levels; BRCA cis rs6752107 1.000 rs2241880 chr2:234183368 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.6 0.42 2.29e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6964587 0.967 rs34344935 chr7:91835436 G/A cg22117172 chr7:91764530 CYP51A1 0.24 8.03 0.3 4.81e-15 Breast cancer; BRCA cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg05623727 chr3:50126028 RBM5 0.5 12.45 0.44 5.4e-32 Intelligence (multi-trait analysis); BRCA cis rs501916 0.634 rs8037600 chr15:48060331 A/G cg16110827 chr15:48056943 SEMA6D -0.43 -9.05 -0.34 1.73e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs3820928 0.874 rs2396452 chr2:227838040 T/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.22 -0.31 1.12e-15 Pulmonary function; BRCA cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg08999081 chr20:33150536 PIGU 0.36 9.28 0.34 2.53e-19 Coronary artery disease; BRCA cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg03146154 chr1:46216737 IPP 0.53 11.57 0.42 2.94e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2070488 1.000 rs2268753 chr3:38500189 C/T cg24069376 chr3:38537580 EXOG 0.41 11.92 0.43 9.9e-30 Electrocardiographic conduction measures; BRCA trans rs61931739 1.000 rs12424741 chr12:34022771 C/T cg26384229 chr12:38710491 ALG10B -0.41 -9.44 -0.35 7e-20 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg03146154 chr1:46216737 IPP -0.47 -10.34 -0.38 2.71e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg26597838 chr10:835615 NA 1.3 21.87 0.65 1.45e-79 Eosinophil percentage of granulocytes; BRCA trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg25482853 chr8:67687455 SGK3 1.06 17.17 0.56 1.31e-54 Lung disease severity in cystic fibrosis; BRCA cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg11752832 chr7:134001865 SLC35B4 0.51 11.87 0.43 1.6800000000000001e-29 Mean platelet volume; BRCA trans rs208515 0.525 rs12215007 chr6:66671008 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -16.05 -0.54 5.92e-49 Exhaled nitric oxide levels; BRCA cis rs4742903 1.000 rs7854630 chr9:106875277 A/C cg14250997 chr9:106856677 SMC2 -0.34 -10.77 -0.39 5.73e-25 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs11191205 0.644 rs7899178 chr10:103359285 G/A cg15320455 chr10:103880129 LDB1 0.46 7.91 0.3 1.1e-14 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.586 rs34727114 chr3:161138929 A/C cg04691961 chr3:161091175 C3orf57 -0.38 -8.28 -0.31 7.19e-16 Morning vs. evening chronotype; BRCA cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg13906792 chr15:75199810 C15orf17 -0.39 -9.23 -0.34 3.96e-19 Breast cancer; BRCA cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg18404041 chr3:52824283 ITIH1 -0.49 -15.25 -0.52 4.96e-45 Bipolar disorder; BRCA cis rs8062405 0.964 rs7187333 chr16:28865916 G/A cg09754948 chr16:28834200 ATXN2L 0.46 8.45 0.32 2.02e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9858542 0.953 rs11711485 chr3:49491983 G/T cg03060546 chr3:49711283 APEH -0.54 -10.77 -0.39 5.96e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs116095464 0.558 rs55833259 chr5:286728 G/A cg22857025 chr5:266934 NA -1.04 -19.68 -0.61 9.4e-68 Breast cancer; BRCA cis rs9473147 0.543 rs9473122 chr6:47474962 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.93e-20 Platelet distribution width;Mean platelet volume; BRCA trans rs61931739 0.517 rs56308002 chr12:34016021 C/G cg13010199 chr12:38710504 ALG10B 0.48 9.21 0.34 4.58e-19 Morning vs. evening chronotype; BRCA cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg19318889 chr4:1322082 MAEA 0.58 12.01 0.43 4.2000000000000004e-30 Longevity; BRCA cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg13073564 chr4:8508604 NA 0.44 11.91 0.43 1.11e-29 Response to antineoplastic agents; BRCA cis rs9649213 0.614 rs2240348 chr7:97984077 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.59 -16.01 -0.54 9.43e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs6840258 1.000 rs75550773 chr4:87955423 G/T cg08197287 chr4:87952173 AFF1 -0.44 -8.78 -0.33 1.48e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -8.58 -0.32 7.07e-17 Neuroticism; BRCA cis rs72928364 1.000 rs62275200 chr3:100696631 C/T cg10123952 chr3:100791384 NA 0.53 7.85 0.3 1.71e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg17971929 chr21:40555470 PSMG1 -0.77 -18.21 -0.58 5.54e-60 Cognitive function; BRCA cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg10556349 chr10:835070 NA 0.59 8.25 0.31 8.76e-16 Eosinophil percentage of granulocytes; BRCA cis rs6598955 0.543 rs3795689 chr1:26560366 C/G cg04990556 chr1:26633338 UBXN11 0.68 11.87 0.42 1.7e-29 Obesity-related traits; BRCA cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg21132104 chr15:45694354 SPATA5L1 -0.73 -16.68 -0.55 4.09e-52 Homoarginine levels; BRCA cis rs9814567 1.000 rs4974484 chr3:134219019 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.45 -0.61 1.55e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.4 9.03 0.34 2e-18 Alzheimer's disease (late onset); BRCA cis rs11785693 0.862 rs73183618 chr8:4988340 T/C cg26367366 chr8:4980734 NA 0.6 10.92 0.4 1.48e-25 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg08213375 chr14:104286397 PPP1R13B -0.53 -12.39 -0.44 9.14e-32 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs7917772 0.503 rs6584510 chr10:104299868 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg04166393 chr7:2884313 GNA12 -0.51 -10.12 -0.37 1.97e-22 Height; BRCA cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4594175 0.926 rs66625118 chr14:51631062 T/C cg23942311 chr14:51606299 NA 0.33 8.3 0.31 6.24e-16 Cancer; BRCA cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg11764359 chr7:65958608 NA 0.63 11.52 0.41 4.94e-28 Aortic root size; BRCA cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.38 -7.85 -0.3 1.81e-14 Alzheimer's disease (late onset); BRCA cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg08000102 chr2:233561755 GIGYF2 0.64 13.86 0.48 2.19e-38 Coronary artery disease; BRCA trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg22491629 chr6:157744540 C6orf35 -0.66 -11.63 -0.42 1.64e-28 Hemostatic factors and hematological phenotypes; BRCA trans rs11098499 0.863 rs3733525 chr4:120447048 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.45 0.44 5.14e-32 Corneal astigmatism; BRCA cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg00857998 chr1:205179979 DSTYK 0.41 8.2 0.31 1.28e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs7715806 0.500 rs17649248 chr5:74998426 C/T cg19683494 chr5:74908142 NA 0.53 8.77 0.33 1.61e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg05347473 chr6:146136440 FBXO30 0.42 8.39 0.32 3.1e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs16958440 0.867 rs78547658 chr18:44669852 C/T cg17192377 chr18:44677553 HDHD2 0.99 13.87 0.48 1.94e-38 Sitting height ratio; BRCA trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg03929089 chr4:120376271 NA 0.46 7.87 0.3 1.53e-14 Axial length; BRCA cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2730245 0.527 rs2730237 chr7:158706166 A/G cg24397884 chr7:158709396 WDR60 0.85 14.32 0.49 1.58e-40 Height; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA trans rs9325144 0.555 rs6582576 chr12:38701230 C/T cg23762105 chr12:34175262 ALG10 0.38 9.4 0.35 9.38e-20 Morning vs. evening chronotype; BRCA cis rs7560272 0.538 rs12233115 chr2:73931891 G/A cg20560298 chr2:73613845 ALMS1 0.34 8.71 0.33 2.6e-17 Schizophrenia; BRCA cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg14844989 chr11:31128820 NA -0.44 -9.49 -0.35 4.33e-20 Red blood cell count; BRCA cis rs4363385 0.782 rs1933381 chr1:153003255 C/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.12 -0.34 9.92e-19 Inflammatory skin disease; BRCA cis rs990171 0.571 rs3771202 chr2:102772669 C/G cg22835712 chr2:102737379 NA 0.54 9.43 0.35 7.18e-20 Lymphocyte counts; BRCA cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg11952622 chr19:58962976 ZNF324B 0.51 10.59 0.39 2.91e-24 Uric acid clearance; BRCA cis rs1577917 1.000 rs1337844 chr6:86677273 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.1 -0.43 1.73e-30 Response to antipsychotic treatment; BRCA cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA trans rs17685 0.712 rs11770149 chr7:75791644 G/A cg19862616 chr7:65841803 NCRNA00174 0.8 24.55 0.7 2.9e-94 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg11789530 chr4:8429930 ACOX3 -0.62 -16.31 -0.54 2.93e-50 Response to antineoplastic agents; BRCA cis rs896854 0.516 rs12679044 chr8:95891356 C/A cg16049864 chr8:95962084 TP53INP1 -0.42 -10.09 -0.37 2.69e-22 Type 2 diabetes; BRCA cis rs16958440 1.000 rs60854219 chr18:44646664 G/A cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.48e-43 Aortic root size; BRCA cis rs2637266 0.902 rs2583056 chr10:78399498 A/G cg18941641 chr10:78392320 NA 0.35 7.98 0.3 6.89e-15 Pulmonary function; BRCA cis rs9837602 0.938 rs9828079 chr3:99806645 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.3e-26 Breast cancer; BRCA cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.02e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.863 rs7678400 chr4:120461957 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.38 8.57 0.32 8e-17 Corneal astigmatism; BRCA cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg11764359 chr7:65958608 NA 0.81 19.52 0.61 6.65e-67 Aortic root size; BRCA cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs892961 0.931 rs2411110 chr17:75400143 A/C cg05865280 chr17:75406074 SEPT9 0.36 9.76 0.36 4.64e-21 Airflow obstruction; BRCA cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 2.02e-19 Schizophrenia; BRCA cis rs2898681 0.874 rs59649036 chr4:53741175 T/C cg00338735 chr4:53728038 RASL11B 0.41 7.82 0.3 2.15e-14 Optic nerve measurement (cup area); BRCA cis rs7927771 0.800 rs35996350 chr11:47389223 A/G cg20307385 chr11:47447363 PSMC3 -0.41 -8.68 -0.32 3.23e-17 Subjective well-being; BRCA cis rs10751667 0.600 rs4076915 chr11:1012464 C/G ch.11.42038R chr11:967971 AP2A2 0.47 14.22 0.49 4.33e-40 Alzheimer's disease (late onset); BRCA cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg02659138 chr7:134003124 SLC35B4 0.32 9.76 0.36 4.42e-21 Mean platelet volume; BRCA cis rs4713118 0.513 rs149897 chr6:28006650 A/G cg10876282 chr6:28092338 ZSCAN16 0.41 7.96 0.3 7.79e-15 Parkinson's disease; BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.65 0.57 4.17e-57 Platelet count; BRCA cis rs7927592 0.956 rs7944870 chr11:68309108 C/G cg20283391 chr11:68216788 NA -0.4 -8.09 -0.3 3.05e-15 Total body bone mineral density; BRCA cis rs7833986 0.501 rs2668007 chr8:56944111 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.6 10.55 0.39 4.31e-24 Height; BRCA cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08704250 chr15:31115839 NA -0.36 -8.7 -0.33 2.83e-17 Huntington's disease progression; BRCA cis rs68170813 0.559 rs78267892 chr7:106823734 C/T cg02696742 chr7:106810147 HBP1 -0.54 -8.83 -0.33 1e-17 Coronary artery disease; BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg08470875 chr2:26401718 FAM59B 0.65 8.47 0.32 1.65e-16 Gut microbiome composition (summer); BRCA cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg17892150 chr10:133769511 PPP2R2D -0.7 -14.38 -0.49 7.87e-41 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg07636037 chr3:49044803 WDR6 0.96 28.39 0.75 2.58e-115 Parkinson's disease; BRCA cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg24549020 chr5:56110836 MAP3K1 0.6 12.36 0.44 1.29e-31 Initial pursuit acceleration; BRCA cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg23029597 chr12:123009494 RSRC2 0.57 11.12 0.4 2.18e-26 Body mass index; BRCA cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg05340658 chr4:99064831 C4orf37 0.67 16.58 0.55 1.29e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg01475377 chr6:109611718 NA -0.59 -16.37 -0.54 1.4e-50 Reticulocyte fraction of red cells; BRCA trans rs66887589 0.967 rs7678973 chr4:120511817 T/C cg25214090 chr10:38739885 LOC399744 -0.35 -8.11 -0.31 2.54e-15 Diastolic blood pressure; BRCA cis rs898097 0.607 rs2199111 chr17:80823203 A/G cg15664640 chr17:80829946 TBCD -0.38 -10.18 -0.37 1.18e-22 Breast cancer; BRCA cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 9.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.37 -0.31 3.51e-16 Monocyte percentage of white cells; BRCA cis rs2303759 0.709 rs2278405 chr19:49812403 A/C cg22307029 chr19:49891270 CCDC155 -0.52 -8.74 -0.33 2.1e-17 Multiple sclerosis; BRCA cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg13271783 chr10:134563150 INPP5A -0.49 -9.95 -0.37 8.44e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs2836974 0.831 rs34294410 chr21:40555160 C/G cg17971929 chr21:40555470 PSMG1 0.79 18.34 0.59 1.08e-60 Cognitive function; BRCA cis rs2073499 0.872 rs58051625 chr3:50278717 G/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.6 8.59 0.32 6.55e-17 Schizophrenia; BRCA cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg25251562 chr2:3704773 ALLC -0.41 -7.9 -0.3 1.21e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs1153858 0.621 rs1706824 chr15:45579948 C/T cg21132104 chr15:45694354 SPATA5L1 0.6 11.9 0.43 1.22e-29 Homoarginine levels; BRCA cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg24692254 chr21:30365293 RNF160 -0.52 -12.05 -0.43 2.7e-30 Cognitive test performance; BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.26 -0.31 8.38e-16 Gut microbiome composition (summer); BRCA cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg04450456 chr4:17643702 FAM184B 0.37 10.91 0.4 1.54e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg05623727 chr3:50126028 RBM5 0.5 12.0 0.43 4.84e-30 Body mass index; BRCA cis rs7666738 0.752 rs35436270 chr4:99088280 G/A cg17366294 chr4:99064904 C4orf37 0.42 8.34 0.31 4.7e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6570726 0.967 rs439017 chr6:145806123 T/C cg23711669 chr6:146136114 FBXO30 0.67 15.65 0.53 5.42e-47 Lobe attachment (rater-scored or self-reported); BRCA trans rs8073060 0.544 rs225283 chr17:33934912 A/G cg19694781 chr19:47549865 TMEM160 -1.06 -21.34 -0.65 1.09e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -13.49 -0.47 1.18e-36 Cognitive function; BRCA cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.74e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11204677 1 rs11204677 chr1:150574695 C/G cg13175981 chr1:150552382 MCL1 0.54 11.79 0.42 3.59e-29 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.546 rs28590002 chr4:98722642 C/T cg05340658 chr4:99064831 C4orf37 0.56 11.09 0.4 3.06e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg21132104 chr15:45694354 SPATA5L1 0.7 15.43 0.52 6.64e-46 Homoarginine levels; BRCA cis rs11190604 1.000 rs2295780 chr10:102305965 A/G cg07080220 chr10:102295463 HIF1AN 0.64 13.77 0.48 5.64e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6429082 0.875 rs2291688 chr1:235594250 A/G cg26050004 chr1:235667680 B3GALNT2 -0.35 -8.18 -0.31 1.54e-15 Adiposity; BRCA cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg16325326 chr1:53192061 ZYG11B 0.69 17.16 0.56 1.36e-54 Monocyte count; BRCA trans rs3733585 0.699 rs10017674 chr4:9967053 T/C cg26043149 chr18:55253948 FECH -0.38 -8.34 -0.31 4.43e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs919433 0.510 rs34631382 chr2:198390009 C/T cg00792783 chr2:198669748 PLCL1 0.36 8.31 0.31 5.72e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg03929089 chr4:120376271 NA -0.53 -8.67 -0.32 3.67e-17 Axial length; BRCA cis rs7586879 0.796 rs916484 chr2:25082588 A/C cg04586622 chr2:25135609 ADCY3 0.37 9.01 0.34 2.34e-18 Body mass index; BRCA cis rs9807989 0.524 rs7594402 chr2:103021267 A/T cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.25e-16 Asthma; BRCA cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg02659138 chr7:134003124 SLC35B4 0.31 9.79 0.36 3.38e-21 Mean platelet volume; BRCA cis rs9341808 0.935 rs2322633 chr6:80845989 C/T cg08355045 chr6:80787529 NA -0.31 -8.07 -0.3 3.5e-15 Sitting height ratio; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg18765753 chr7:1198926 ZFAND2A -0.46 -10.56 -0.39 3.9e-24 Longevity;Endometriosis; BRCA cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg01483505 chr11:975446 AP2A2 0.31 8.48 0.32 1.53e-16 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg00339695 chr16:24857497 SLC5A11 0.49 9.92 0.37 1.18e-21 Intelligence (multi-trait analysis); BRCA cis rs7799006 0.782 rs2159044 chr7:2262941 C/A cg08027265 chr7:2291960 NA -0.34 -8.89 -0.33 6.43e-18 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg05729581 chr11:3078854 CARS -0.34 -8.49 -0.32 1.43e-16 Longevity; BRCA cis rs899997 0.862 rs57260218 chr15:78973772 C/T cg04896959 chr15:78267971 NA -0.45 -10.52 -0.38 5.69e-24 Coronary artery disease or large artery stroke; BRCA cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg04414720 chr1:150670196 GOLPH3L 0.36 8.34 0.31 4.72e-16 Tonsillectomy; BRCA cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg14582100 chr15:45693742 SPATA5L1 0.37 11.83 0.42 2.38e-29 Homoarginine levels; BRCA cis rs11229555 0.645 rs12801475 chr11:58189034 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg21143896 chr7:2802374 GNA12 -0.34 -8.44 -0.32 2.12e-16 Height; BRCA cis rs4423214 0.840 rs1792234 chr11:71182018 T/C cg05163923 chr11:71159392 DHCR7 -0.57 -11.46 -0.41 9.02e-28 Vitamin D levels; BRCA cis rs61931739 0.500 rs34997501 chr12:34549828 C/G cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs6867032 1.000 rs4398675 chr5:2015816 G/A cg26168224 chr5:2018326 NA 0.64 17.71 0.57 2.02e-57 Gut microbiome composition (winter); BRCA cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.22 0.76 7.53e-120 Cognitive function; BRCA cis rs11920090 0.720 rs58284370 chr3:170738849 G/A cg09710316 chr3:170744871 SLC2A2 0.64 10.28 0.38 4.89e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg05340658 chr4:99064831 C4orf37 0.63 15.15 0.51 1.51e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs936229 0.813 rs2301249 chr15:75092384 T/C cg10253484 chr15:75165896 SCAMP2 -0.51 -9.8 -0.36 3.29e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs4851870 0.514 rs4851840 chr2:106369253 G/C cg15488963 chr2:106262226 NA 0.39 8.2 0.31 1.28e-15 Addiction; BRCA cis rs3617 0.539 rs11922975 chr3:52936763 C/T cg11645453 chr3:52864694 ITIH4 -0.35 -9.42 -0.35 8.1e-20 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg23533926 chr12:111358616 MYL2 0.41 8.61 0.32 5.64e-17 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg22920501 chr2:26401640 FAM59B -0.64 -11.15 -0.4 1.61e-26 Gut microbiome composition (summer); BRCA cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg19077165 chr18:44547161 KATNAL2 -0.39 -8.27 -0.31 7.79e-16 Educational attainment; BRCA cis rs9790314 0.632 rs62280333 chr3:160689060 G/A cg03342759 chr3:160939853 NMD3 0.47 9.14 0.34 8.53e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.581 rs34205844 chr4:98887494 C/A cg05340658 chr4:99064831 C4orf37 0.61 14.5 0.5 2.05e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs4689388 0.750 rs10001190 chr4:6284633 C/T cg25554036 chr4:6271136 WFS1 -0.36 -8.04 -0.3 4.31e-15 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg21782813 chr7:2030301 MAD1L1 0.37 10.79 0.39 4.62e-25 Bipolar disorder and schizophrenia; BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg27170947 chr2:26402098 FAM59B -0.93 -16.88 -0.56 4.1e-53 Gut microbiome composition (summer); BRCA cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg19628046 chr18:33552617 C18orf21 0.54 10.62 0.39 2.2e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs10207060 1.000 rs10207060 chr2:240687289 A/C cg07506560 chr2:240697449 NA 0.49 10.87 0.39 2.35e-25 Obesity-related traits; BRCA cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg11890956 chr21:40555474 PSMG1 0.98 23.88 0.69 1.43e-90 Cognitive function; BRCA trans rs61931739 0.517 rs12367881 chr12:34175508 T/C cg13010199 chr12:38710504 ALG10B 0.5 9.74 0.36 5.54e-21 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg21475434 chr5:93447410 FAM172A 0.66 8.7 0.33 2.8e-17 Diabetic retinopathy; BRCA cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg20607287 chr7:12443886 VWDE -0.58 -8.32 -0.31 5.34e-16 Coronary artery disease; BRCA cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.88 0.74 1.6e-112 Chronic sinus infection; BRCA cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.79 -0.42 3.6e-29 Alcohol dependence; BRCA cis rs4363385 0.747 rs1577964 chr1:152961784 C/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.3e-17 Inflammatory skin disease; BRCA cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.13 -0.4 1.98e-26 Extrinsic epigenetic age acceleration; BRCA cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg02896835 chr1:92012615 NA 0.44 8.32 0.31 5.16e-16 Eosinophil percentage of white cells; BRCA cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg18446336 chr7:2847575 GNA12 -0.34 -8.19 -0.31 1.4e-15 Height; BRCA cis rs4566357 0.576 rs3769644 chr2:227917240 C/G cg11843606 chr2:227700838 RHBDD1 -0.43 -9.55 -0.35 2.65e-20 Coronary artery disease; BRCA cis rs710865 0.519 rs3748759 chr1:19487656 C/T cg13387374 chr1:19411106 UBR4 -0.42 -9.24 -0.34 3.66e-19 Brain structure; BRCA cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg04455712 chr21:45112962 RRP1B 0.41 10.93 0.4 1.29e-25 Mean corpuscular volume; BRCA cis rs597539 0.652 rs501799 chr11:68631240 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 16.67 0.55 4.51e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs4690686 0.538 rs4690687 chr4:177259635 A/G cg17059388 chr4:177262070 NA -0.5 -10.39 -0.38 1.82e-23 Essential tremor; BRCA cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg07138768 chr7:917805 C7orf20 0.28 7.92 0.3 1.02e-14 Perceived unattractiveness to mosquitoes; BRCA cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg18357526 chr6:26021779 HIST1H4A 0.46 8.51 0.32 1.21e-16 Intelligence (multi-trait analysis); BRCA cis rs12579753 0.917 rs7313521 chr12:82205656 G/A cg07988820 chr12:82153109 PPFIA2 -0.48 -8.42 -0.32 2.41e-16 Resting heart rate; BRCA cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg03452623 chr4:187889614 NA -0.35 -11.19 -0.4 1.19e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.509 rs12176511 chr6:79565721 G/A cg05283184 chr6:79620031 NA 0.36 8.99 0.34 2.67e-18 Intelligence (multi-trait analysis); BRCA cis rs2112347 0.502 rs34342 chr5:74934213 A/C cg19683494 chr5:74908142 NA -0.63 -10.28 -0.38 4.77e-23 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Hip circumference;Body mass index;Body mass index in physically active individuals;Obesity; BRCA cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg06212747 chr3:49208901 KLHDC8B 0.47 9.66 0.36 1.09e-20 Parkinson's disease; BRCA cis rs1568889 1.000 rs7937778 chr11:28104605 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.54 0.5 1.37e-41 Bipolar disorder; BRCA cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.75e-15 Developmental language disorder (linguistic errors); BRCA cis rs17092148 1.000 rs62211617 chr20:33400355 C/G cg16810054 chr20:33298113 TP53INP2 0.5 11.25 0.41 6.79e-27 Neuroticism; BRCA cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg08603382 chr10:743973 NA -0.46 -8.64 -0.32 4.44e-17 Psychosis in Alzheimer's disease; BRCA cis rs7178424 1.000 rs12438803 chr15:62374942 T/A cg00456672 chr15:62358751 C2CD4A -0.35 -8.3 -0.31 6.42e-16 Height; BRCA cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg01579765 chr21:45077557 HSF2BP -0.43 -11.68 -0.42 1.02e-28 Mean corpuscular volume; BRCA cis rs3820928 0.874 rs55743026 chr2:227802813 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.72 -0.33 2.42e-17 Pulmonary function; BRCA cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg22875332 chr1:76189707 ACADM 0.69 14.91 0.51 2.21e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4566357 0.615 rs3769642 chr2:227917323 T/C cg05526886 chr2:227700861 RHBDD1 -0.4 -8.31 -0.31 5.82e-16 Coronary artery disease; BRCA cis rs13064411 0.518 rs2669909 chr3:113265727 A/G cg18753928 chr3:113234510 CCDC52 0.4 9.13 0.34 8.98e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.72e-22 Bladder cancer; BRCA cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg08999081 chr20:33150536 PIGU -0.45 -12.15 -0.43 1.03e-30 Glomerular filtration rate (creatinine); BRCA cis rs870825 0.860 rs72689295 chr4:185600930 T/C cg04058563 chr4:185651563 MLF1IP 0.82 13.82 0.48 3.56e-38 Blood protein levels; BRCA cis rs6546550 0.867 rs1551374 chr2:70079633 C/T cg02498382 chr2:70120550 SNRNP27 -0.49 -10.21 -0.37 8.82e-23 Prevalent atrial fibrillation; BRCA cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg22535103 chr8:58192502 C8orf71 -0.49 -8.6 -0.32 5.95e-17 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg21918786 chr6:109611834 NA -0.49 -14.15 -0.49 1.02e-39 Reticulocyte fraction of red cells; BRCA cis rs7565124 1.000 rs7568106 chr2:20261969 G/A cg23821541 chr2:20251993 LAPTM4A 0.37 7.83 0.3 2.07e-14 Major depressive disorder; BRCA cis rs10465746 0.780 rs11163862 chr1:84355418 A/T cg10977910 chr1:84465055 TTLL7 -0.56 -11.78 -0.42 3.89e-29 Obesity-related traits; BRCA cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs743757 1.000 rs2236955 chr3:50429876 G/A cg05260129 chr3:50388622 TUSC4;CYB561D2 0.45 7.92 0.3 1.08e-14 Diastolic blood pressure; BRCA cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg15997130 chr1:24165203 NA -0.45 -10.18 -0.37 1.12e-22 Immature fraction of reticulocytes; BRCA cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 3.02e-25 Bipolar disorder; BRCA cis rs2274471 0.591 rs7034539 chr9:5081585 C/T cg03390472 chr9:5043263 JAK2 0.48 8.6 0.32 6.33e-17 Crohn's disease; BRCA cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg17971929 chr21:40555470 PSMG1 -0.62 -14.46 -0.5 3.37e-41 Cognitive function; BRCA cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg04267008 chr7:1944627 MAD1L1 -0.46 -9.81 -0.36 3.08e-21 Bipolar disorder and schizophrenia; BRCA cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg16262614 chr3:133464971 TF -0.25 -8.12 -0.31 2.41e-15 Iron status biomarkers (transferrin levels); BRCA cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg20887711 chr4:1340912 KIAA1530 0.42 10.2 0.37 1.02e-22 Longevity; BRCA cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs2412459 1.000 rs2279581 chr15:40300092 A/G cg10636054 chr15:40330586 SRP14 0.5 8.41 0.32 2.67e-16 Response to haloperidol in psychosis; BRCA cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.44 -0.32 2.08e-16 Monocyte percentage of white cells; BRCA trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg22491629 chr6:157744540 C6orf35 -0.66 -11.63 -0.42 1.64e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs2204008 0.807 rs10880234 chr12:38318353 C/T cg13010199 chr12:38710504 ALG10B 0.52 10.19 0.37 1.05e-22 Bladder cancer; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg24101359 chr6:42928495 GNMT 0.55 12.98 0.46 2.32e-34 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg08219700 chr8:58056026 NA 0.54 8.98 0.33 2.94e-18 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg22875332 chr1:76189707 ACADM -0.53 -10.27 -0.38 5.49e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504073 0.647 rs62507246 chr8:50013449 G/A cg00325661 chr8:49890786 NA 0.44 12.52 0.44 2.54e-32 Blood metabolite ratios; BRCA cis rs9325144 0.577 rs12314639 chr12:39119869 T/C cg26384229 chr12:38710491 ALG10B -0.43 -10.38 -0.38 2e-23 Morning vs. evening chronotype; BRCA cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg05025164 chr4:1340916 KIAA1530 0.59 12.33 0.44 1.66e-31 Longevity; BRCA cis rs16854884 0.802 rs6783329 chr3:143798454 T/G cg06585982 chr3:143692056 C3orf58 0.44 8.88 0.33 6.67e-18 Economic and political preferences (feminism/equality); BRCA cis rs826838 0.616 rs10880754 chr12:38628154 C/T cg26384229 chr12:38710491 ALG10B -0.45 -10.34 -0.38 2.73e-23 Heart rate; BRCA cis rs7786808 0.741 rs4909222 chr7:158228095 C/T cg09998033 chr7:158218633 PTPRN2 0.4 9.52 0.35 3.46e-20 Obesity-related traits; BRCA cis rs10733682 0.524 rs10987422 chr9:129462687 C/A cg00232160 chr9:129468157 NA 0.35 8.09 0.3 3.1e-15 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg21143896 chr7:2802374 GNA12 -0.38 -9.53 -0.35 3.1e-20 Height; BRCA cis rs6088813 1.000 rs6142370 chr20:33973378 G/A cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.1e-17 Height; BRCA cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg06552810 chr11:31128660 NA -0.39 -8.77 -0.33 1.59e-17 Red blood cell count; BRCA cis rs3820928 0.874 rs10202239 chr2:227901819 C/T cg11843606 chr2:227700838 RHBDD1 -0.36 -7.91 -0.3 1.16e-14 Pulmonary function; BRCA cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg04450456 chr4:17643702 FAM184B -0.33 -9.4 -0.35 9.83e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1190552 0.846 rs3783381 chr14:102965435 A/G cg18135206 chr14:102964638 TECPR2 0.46 8.9 0.33 5.89e-18 Blood protein levels; BRCA cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA trans rs1005277 0.579 rs1780138 chr10:38501654 A/G cg23533926 chr12:111358616 MYL2 -0.43 -9.14 -0.34 8.32e-19 Extrinsic epigenetic age acceleration; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg10150615 chr22:24372951 LOC391322 -0.44 -9.88 -0.36 1.66e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17376456 1.000 rs35184505 chr5:93561535 A/G cg21475434 chr5:93447410 FAM172A 0.7 8.93 0.33 4.37e-18 Diabetic retinopathy; BRCA cis rs910316 0.935 rs175076 chr14:75505486 A/G cg23033748 chr14:75592666 NEK9 -0.41 -9.93 -0.37 1e-21 Height; BRCA cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg11812906 chr14:75593930 NEK9 -0.61 -13.88 -0.48 1.76e-38 Height; BRCA cis rs1448094 0.512 rs10863086 chr12:86244225 G/A cg19622623 chr12:86230825 RASSF9 -0.33 -9.31 -0.35 2.09e-19 Major depressive disorder; BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg08805041 chr16:621841 PIGQ -0.33 -8.99 -0.34 2.82e-18 Height; BRCA cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg08213375 chr14:104286397 PPP1R13B -0.49 -11.01 -0.4 6.23e-26 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs11112613 0.713 rs12580741 chr12:105941328 A/G cg03607813 chr12:105948248 NA -0.53 -9.66 -0.36 1.04e-20 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg23029597 chr12:123009494 RSRC2 -0.61 -11.79 -0.42 3.46e-29 Body mass index; BRCA cis rs3772130 0.962 rs6768621 chr3:121530274 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.91 0.4 1.63e-25 Cognitive performance; BRCA cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.54 11.6 0.42 2.32e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 8.36 0.31 3.97e-16 Schizophrenia; BRCA cis rs2762353 0.574 rs9467573 chr6:25704190 C/A cg03264133 chr6:25882463 NA 0.71 16.19 0.54 1.12e-49 Blood metabolite levels; BRCA trans rs1493916 0.905 rs34910379 chr18:31400047 A/G cg15819921 chr19:927150 ARID3A -0.51 -9.69 -0.36 8.22e-21 Life satisfaction; BRCA cis rs77686669 1 rs77686669 chr7:99744572 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.47 8.16 0.31 1.73e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs1030877 0.515 rs2679895 chr2:105906480 C/G cg02079111 chr2:105885981 TGFBRAP1 0.62 12.04 0.43 3.19e-30 Obesity-related traits; BRCA cis rs13631 0.965 rs9411307 chr9:139994947 C/T cg14289826 chr9:140003911 NA 0.52 13.8 0.48 4.25e-38 Cerebrospinal fluid biomarker levels; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg12564285 chr5:131593104 PDLIM4 0.43 11.04 0.4 4.77e-26 Acylcarnitine levels; BRCA cis rs2637266 0.935 rs12414653 chr10:78394071 C/G cg18941641 chr10:78392320 NA 0.36 8.28 0.31 7.41e-16 Pulmonary function; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg22907277 chr7:1156413 C7orf50 0.5 11.14 0.4 1.84e-26 Longevity;Endometriosis; BRCA trans rs12579753 0.879 rs11115009 chr12:82165409 G/T cg07923666 chr12:49932857 KCNH3 0.4 7.82 0.3 2.25e-14 Resting heart rate; BRCA trans rs11098499 0.644 rs7676296 chr4:120555687 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.2 0.37 9.49e-23 Corneal astigmatism; BRCA cis rs9790314 0.718 rs9847866 chr3:160758275 A/G cg03342759 chr3:160939853 NMD3 -0.49 -9.25 -0.34 3.39e-19 Morning vs. evening chronotype; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg13628971 chr7:2884303 GNA12 0.47 9.13 0.34 8.69e-19 Height; BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg13047869 chr3:10149882 C3orf24 0.51 9.51 0.35 3.77e-20 Alzheimer's disease; BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg12564285 chr5:131593104 PDLIM4 0.36 9.55 0.35 2.64e-20 Breast cancer; BRCA cis rs61931739 0.517 rs11513277 chr12:34074799 G/T cg06521331 chr12:34319734 NA -0.62 -11.16 -0.4 1.52e-26 Morning vs. evening chronotype; BRCA cis rs74417235 0.684 rs13186731 chr5:154056002 C/T cg08754654 chr5:154026448 NA 0.43 10.11 0.37 2.11e-22 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03576123 chr11:487126 PTDSS2 -1.2 -18.77 -0.6 6.11e-63 Body mass index; BRCA trans rs12439619 0.883 rs62012045 chr15:82521707 G/A cg04831495 chr15:85060580 GOLGA6L5 -0.46 -11.24 -0.41 6.94e-27 Intelligence (multi-trait analysis); BRCA cis rs853679 0.517 rs9393888 chr6:28059217 G/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.17e-15 Depression; BRCA trans rs2197308 0.765 rs117216293 chr12:37882982 T/C cg06521331 chr12:34319734 NA 0.45 8.9 0.33 5.72e-18 Morning vs. evening chronotype; BRCA cis rs11105298 0.891 rs11105312 chr12:89920733 C/T cg00757033 chr12:89920650 WDR51B 0.55 11.24 0.41 7.05e-27 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg27398817 chr8:82754497 SNX16 -0.38 -8.13 -0.31 2.16e-15 Diastolic blood pressure; BRCA cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -10.81 -0.39 4.09e-25 IgG glycosylation; BRCA cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg21545522 chr1:205238299 TMCC2 0.37 8.19 0.31 1.43e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg08470875 chr2:26401718 FAM59B -0.51 -8.24 -0.31 9.64e-16 Gut microbiome composition (summer); BRCA cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.32 0.31 5.33e-16 Menopause (age at onset); BRCA cis rs3008870 1.000 rs2009319 chr1:67481070 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.73 0.65 7.9e-79 Lymphocyte percentage of white cells; BRCA cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg01256987 chr12:42539512 GXYLT1 -0.4 -7.82 -0.3 2.21e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs8017423 0.605 rs4904676 chr14:90819220 G/A cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs10193935 1.000 rs4048 chr2:42424595 A/C cg27598129 chr2:42591480 NA -0.99 -14.71 -0.5 2.03e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs2282802 0.617 rs10477348 chr5:139666906 A/T cg26211634 chr5:139558579 C5orf32 0.35 8.21 0.31 1.19e-15 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA cis rs708547 0.871 rs2687238 chr4:57880474 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.5 12.01 0.43 4.15e-30 Response to bleomycin (chromatid breaks); BRCA cis rs2859741 0.565 rs11263962 chr1:37509239 C/T cg09363841 chr1:37513479 NA -0.54 -11.71 -0.42 8.16e-29 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg24060327 chr5:131705240 SLC22A5 -0.46 -9.16 -0.34 7.14e-19 Acylcarnitine levels; BRCA cis rs2806561 0.754 rs10917337 chr1:23300723 G/A cg19743168 chr1:23544995 NA -0.41 -9.78 -0.36 3.68e-21 Height; BRCA cis rs897080 0.515 rs1067351 chr2:44669907 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.19 0.34 5.54e-19 Height; BRCA cis rs7586879 0.789 rs13428763 chr2:25132855 T/G cg04586622 chr2:25135609 ADCY3 0.4 9.44 0.35 7.05e-20 Body mass index; BRCA cis rs13082711 0.871 rs7624790 chr3:27468601 C/A cg02860705 chr3:27208620 NA 0.53 10.65 0.39 1.65e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7568458 0.709 rs11895399 chr2:85753806 C/A cg02493740 chr2:85810744 VAMP5 -0.51 -10.58 -0.39 3.16e-24 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.42 -0.38 1.37e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg02228329 chr11:64053129 BAD;GPR137 0.54 11.9 0.43 1.18e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs4820539 1.000 rs4822357 chr22:23473231 A/G cg14186256 chr22:23484241 RTDR1 0.77 22.44 0.66 1.1e-82 Bone mineral density; BRCA cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.42 0.38 1.41e-23 Drug-induced liver injury (flucloxacillin); BRCA trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21659725 chr3:3221576 CRBN -0.49 -12.55 -0.44 1.8e-32 Intelligence (multi-trait analysis); BRCA cis rs9640161 0.789 rs10282458 chr7:150045302 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.49 -12.07 -0.43 2.24e-30 Blood protein levels;Circulating chemerin levels; BRCA cis rs798766 1.000 rs1374469 chr4:1724799 C/T cg05874882 chr4:1763078 NA -0.46 -8.42 -0.32 2.43e-16 Bladder cancer;Urinary bladder cancer; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg23708337 chr7:1209742 NA 0.44 8.36 0.31 4.01e-16 Longevity;Endometriosis; BRCA cis rs9420 0.796 rs685149 chr11:57657413 A/G cg19752551 chr11:57585705 CTNND1 0.42 10.74 0.39 7.41e-25 Schizophrenia; BRCA cis rs921968 0.565 rs6723334 chr2:219629303 C/T cg02176678 chr2:219576539 TTLL4 0.4 10.88 0.4 1.98e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs7100689 0.524 rs7902460 chr10:82199263 T/A cg00277334 chr10:82204260 NA -0.61 -14.02 -0.49 3.75e-39 Post bronchodilator FEV1; BRCA cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg10523679 chr1:76189770 ACADM -0.52 -9.64 -0.36 1.23e-20 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg18016565 chr1:150552671 MCL1 -0.39 -9.5 -0.35 4.1e-20 Urate levels; BRCA cis rs56104184 0.775 rs56149557 chr19:49401384 C/A cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg00814883 chr7:100076585 TSC22D4 0.55 11.69 0.42 9.37e-29 Platelet count; BRCA cis rs1865760 0.688 rs1436310 chr6:25969958 G/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.98 0.37 6.82e-22 Height; BRCA cis rs12478296 1.000 rs59036157 chr2:243040228 C/A cg06360820 chr2:242988706 NA -0.86 -14.92 -0.51 2.11e-43 Obesity-related traits; BRCA cis rs9633740 0.947 rs7096909 chr10:82284512 A/T cg00277334 chr10:82204260 NA 0.49 8.14 0.31 2.15e-15 Post bronchodilator FEV1; BRCA cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg06494592 chr3:125709126 NA -0.54 -8.36 -0.31 4.06e-16 Blood pressure (smoking interaction); BRCA cis rs870825 0.616 rs72703531 chr4:185611092 C/T cg04058563 chr4:185651563 MLF1IP 0.85 16.21 0.54 8.96e-50 Blood protein levels; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg19626725 chr5:178986131 RUFY1 0.36 11.3 0.41 3.99e-27 Lung cancer; BRCA cis rs6942756 0.876 rs822040 chr7:129065922 C/G cg02491457 chr7:128862824 NA 0.6 12.57 0.45 1.49e-32 White matter hyperintensity burden; BRCA cis rs9658691 0.607 rs9658757 chr10:90769455 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.55 -8.01 -0.3 5.57e-15 Mosquito bite size; BRCA cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg15352829 chr14:105391018 PLD4 -0.38 -12.39 -0.44 9.37e-32 Rheumatoid arthritis; BRCA cis rs6977660 0.943 rs10270447 chr7:19849823 C/G cg05791153 chr7:19748676 TWISTNB -0.41 -8.57 -0.32 8.02e-17 Thyroid stimulating hormone; BRCA cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.38 0.38 2.04e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg12564285 chr5:131593104 PDLIM4 0.37 10.06 0.37 3.39e-22 Breast cancer; BRCA cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg09555818 chr19:45449301 APOC2 -0.55 -14.48 -0.5 2.6e-41 Blood protein levels; BRCA cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg24562669 chr7:97807699 LMTK2 0.48 13.34 0.47 5.69e-36 Breast cancer; BRCA cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9880211 1.000 rs67949818 chr3:136212978 G/A cg21827317 chr3:136751795 NA -0.45 -8.22 -0.31 1.12e-15 Body mass index;Height; BRCA cis rs4803468 0.967 rs3826713 chr19:41892269 C/T cg09537434 chr19:41945824 ATP5SL -0.99 -23.95 -0.69 5.75e-91 Height; BRCA cis rs9393777 0.623 rs9358948 chr6:26483806 G/A cg12826209 chr6:26865740 GUSBL1 0.56 9.17 0.34 6.68e-19 Intelligence (multi-trait analysis); BRCA cis rs2658782 1.000 rs2608216 chr11:93149172 G/A cg15737290 chr11:93063684 CCDC67 0.54 10.29 0.38 4.6e-23 Pulmonary function decline; BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.05 0.3 3.93e-15 Tonsillectomy; BRCA cis rs6005807 0.545 rs134488 chr22:28728344 G/A cg12565055 chr22:29076175 TTC28 -0.44 -7.83 -0.3 1.98e-14 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.02e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7707921 0.767 rs226199 chr5:81572464 G/C cg15871215 chr5:81402204 ATG10 0.36 8.32 0.31 5.15e-16 Breast cancer; BRCA cis rs9486715 0.867 rs4839828 chr6:96863326 G/A cg06623918 chr6:96969491 KIAA0776 0.89 25.14 0.71 1.8e-97 Headache; BRCA cis rs8180040 0.966 rs7628631 chr3:47560863 C/T cg27129171 chr3:47204927 SETD2 -0.67 -14.87 -0.51 3.74e-43 Colorectal cancer; BRCA cis rs4689388 0.926 rs6446480 chr4:6295565 C/T cg25554036 chr4:6271136 WFS1 0.41 9.58 0.35 2.18e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9300255 0.739 rs1879380 chr12:123739111 G/A cg00376283 chr12:123451042 ABCB9 -0.57 -10.9 -0.4 1.65e-25 Neutrophil percentage of white cells; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg00814883 chr7:100076585 TSC22D4 -0.54 -10.68 -0.39 1.27e-24 Platelet count; BRCA cis rs13046373 0.535 rs1911571 chr21:32031538 A/C cg24082983 chr21:31802169 KRTAP13-4 0.33 8.42 0.32 2.39e-16 HDL cholesterol; BRCA cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg08807101 chr21:30365312 RNF160 -0.76 -20.05 -0.62 1e-69 Dental caries; BRCA cis rs7824557 0.815 rs958648 chr8:11103895 A/G cg21775007 chr8:11205619 TDH -0.38 -8.06 -0.3 3.68e-15 Retinal vascular caliber; BRCA trans rs11088226 0.681 rs2833891 chr21:33928821 A/G cg09050820 chr6:167586206 TCP10L2 0.79 14.32 0.49 1.59e-40 Gastritis; BRCA cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg16006841 chr5:176797999 RGS14 0.78 14.28 0.49 2.28e-40 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs16976116 0.901 rs28564077 chr15:55495151 G/A cg11288833 chr15:55489084 RSL24D1 0.48 10.68 0.39 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA trans rs12439619 0.921 rs4778672 chr15:82537354 G/T cg04831495 chr15:85060580 GOLGA6L5 0.45 11.0 0.4 6.93e-26 Intelligence (multi-trait analysis); BRCA cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg18904891 chr8:8559673 CLDN23 0.64 12.48 0.44 3.89e-32 Obesity-related traits; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 18.99 0.6 4.41e-64 Platelet count; BRCA trans rs61931739 0.635 rs7138254 chr12:33914422 G/T cg26384229 chr12:38710491 ALG10B 0.4 8.98 0.33 3.05e-18 Morning vs. evening chronotype; BRCA trans rs9291683 0.546 rs12504565 chr4:10045145 G/A cg26043149 chr18:55253948 FECH 0.4 8.73 0.33 2.17e-17 Bone mineral density; BRCA cis rs7582180 0.790 rs13020451 chr2:100927131 T/G cg14675211 chr2:100938903 LONRF2 0.48 11.08 0.4 3.09e-26 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.14 0.37 1.62e-22 Bladder cancer; BRCA cis rs6783573 0.965 rs7650998 chr3:46607255 C/T cg16875182 chr3:46619291 LRRC2;TDGF1 0.41 8.31 0.31 5.75e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs113835537 0.559 rs57045447 chr11:66339683 A/G cg24851651 chr11:66362959 CCS 0.45 8.59 0.32 6.55e-17 Airway imaging phenotypes; BRCA cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02475777 chr4:1388615 CRIPAK 0.66 12.77 0.45 1.98e-33 Longevity; BRCA cis rs3820928 0.874 rs4675132 chr2:227841792 A/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.27 -0.31 7.92e-16 Pulmonary function; BRCA cis rs9868809 0.656 rs13324119 chr3:48710606 G/C cg00383909 chr3:49044727 WDR6 0.56 9.78 0.36 3.97e-21 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.46e-15 Developmental language disorder (linguistic errors); BRCA cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg06640241 chr16:89574553 SPG7 0.56 11.95 0.43 7.93e-30 Multiple myeloma (IgH translocation); BRCA trans rs4714291 0.832 rs7764688 chr6:40115442 G/T cg02267698 chr19:7991119 CTXN1 -0.46 -9.49 -0.35 4.57e-20 Strep throat; BRCA cis rs7246657 0.550 rs10411176 chr19:37686953 G/T cg14683738 chr19:37701593 ZNF585B 0.52 7.81 0.3 2.32e-14 Coronary artery calcification; BRCA cis rs12541635 0.677 rs34872724 chr8:107033071 C/T cg10147462 chr8:107024639 NA -0.39 -10.57 -0.39 3.46e-24 Age of smoking initiation; BRCA cis rs3806843 0.733 rs801181 chr5:140092814 C/T cg16179182 chr5:140090404 VTRNA1-1 0.42 9.71 0.36 6.95e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg10845886 chr2:3471009 TTC15 -0.5 -10.71 -0.39 9.6e-25 Neurofibrillary tangles; BRCA cis rs4853036 1.000 rs56223710 chr2:70049715 C/T cg02498382 chr2:70120550 SNRNP27 -0.49 -8.9 -0.33 5.59e-18 Colorectal or endometrial cancer; BRCA trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs8114671 0.647 rs945959 chr20:33734905 G/C cg24642439 chr20:33292090 TP53INP2 0.4 8.58 0.32 7.04e-17 Height; BRCA cis rs2731664 0.792 rs335467 chr5:176890642 A/G cg23176889 chr5:176863531 GRK6 -0.6 -16.42 -0.54 8.15e-51 Intelligence (multi-trait analysis); BRCA cis rs17092148 0.836 rs4911157 chr20:33167075 T/C cg16810054 chr20:33298113 TP53INP2 -0.48 -10.45 -0.38 1.06e-23 Neuroticism; BRCA cis rs9790314 1.000 rs336593 chr3:161076431 T/C cg04691961 chr3:161091175 C3orf57 -0.6 -15.12 -0.51 2.13e-44 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg07606381 chr6:8435919 SLC35B3 -0.66 -14.37 -0.49 8.75e-41 Motion sickness; BRCA trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.56 8.54 0.32 9.87e-17 Gut microbiome composition (summer); BRCA cis rs798554 0.704 rs798513 chr7:2782493 C/T cg19717773 chr7:2847554 GNA12 -0.43 -9.45 -0.35 6.5e-20 Height; BRCA trans rs4714291 0.963 rs9369159 chr6:39998853 T/C cg02267698 chr19:7991119 CTXN1 0.4 7.92 0.3 1.08e-14 Strep throat; BRCA trans rs6479891 0.908 rs11819167 chr10:64976169 G/A cg14819942 chr15:35414228 NA 0.34 8.48 0.32 1.58e-16 Arthritis (juvenile idiopathic); BRCA cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg08704250 chr15:31115839 NA 0.34 8.81 0.33 1.19e-17 Huntington's disease progression; BRCA cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg08045932 chr20:61659980 NA 0.5 11.55 0.42 3.63e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs3845702 0.935 rs6433822 chr2:180840422 G/C cg01881094 chr2:180872142 CWC22 -0.66 -12.58 -0.45 1.43e-32 Schizophrenia; BRCA cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg06544989 chr22:39130855 UNC84B 0.34 7.94 0.3 9.19e-15 Menopause (age at onset); BRCA cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg14829155 chr15:31115871 NA -0.42 -9.7 -0.36 7.72e-21 Huntington's disease progression; BRCA cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg06453172 chr10:134556979 INPP5A -0.6 -11.88 -0.43 1.45e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs147120681 1 rs147120681 chr1:101239293 CT/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.41 -10.36 -0.38 2.29e-23 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs7103648 0.669 rs7131262 chr11:47836302 T/A cg20307385 chr11:47447363 PSMC3 0.72 15.82 0.53 8.23e-48 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg08917208 chr2:24149416 ATAD2B 0.54 8.23 0.31 1.06e-15 Lymphocyte counts; BRCA cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg24130564 chr14:104152367 KLC1 -0.41 -10.02 -0.37 4.85e-22 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.75 16.53 0.55 2.32e-51 Lymphocyte counts; BRCA cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg22834771 chr12:69754056 YEATS4 -0.39 -9.64 -0.36 1.29e-20 Blood protein levels; BRCA cis rs67460515 0.892 rs35100811 chr3:161084046 A/C cg03342759 chr3:160939853 NMD3 -0.72 -16.33 -0.54 2.28e-50 Parkinson's disease; BRCA trans rs1005277 0.603 rs1998062 chr10:38457652 G/C cg17830980 chr10:43048298 ZNF37B -0.56 -13.8 -0.48 4.14e-38 Extrinsic epigenetic age acceleration; BRCA cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11644478 chr21:40555479 PSMG1 0.84 19.32 0.61 7.72e-66 Cognitive function; BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs1506636 0.924 rs4370458 chr7:123260968 G/A cg03229431 chr7:123269106 ASB15 -0.66 -15.28 -0.52 3.91e-45 Plateletcrit;Platelet count; BRCA cis rs4302748 0.862 rs11980735 chr7:36183683 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.5 -0.32 1.35e-16 Monocyte percentage of white cells; BRCA cis rs11690935 0.550 rs4280427 chr2:172813218 G/A cg13550731 chr2:172543902 DYNC1I2 0.54 13.01 0.46 1.62e-34 Schizophrenia; BRCA cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg18230493 chr5:56204884 C5orf35 -0.68 -13.75 -0.48 7.51e-38 Initial pursuit acceleration; BRCA cis rs2882667 0.654 rs288019 chr5:138191393 A/G cg04439458 chr5:138467593 SIL1 0.31 7.94 0.3 9.37e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs1459104 1.000 rs12795435 chr11:55047287 C/T cg15704280 chr7:45808275 SEPT13 0.64 8.36 0.31 3.82e-16 Body mass index; BRCA cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.37 8.56 0.32 8.64e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -8.2 -0.31 1.33e-15 Longevity;Endometriosis; BRCA trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg24531977 chr5:56204891 C5orf35 0.71 15.72 0.53 2.7e-47 Initial pursuit acceleration; BRCA cis rs9325144 0.624 rs10783333 chr12:39118931 A/T cg26384229 chr12:38710491 ALG10B 0.44 10.7 0.39 1.08e-24 Morning vs. evening chronotype; BRCA cis rs6582630 0.548 rs8189608 chr12:38327775 T/G cg26384229 chr12:38710491 ALG10B -0.42 -9.61 -0.36 1.6e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs10503871 0.967 rs2294085 chr8:30436779 C/T cg26383811 chr8:30366931 RBPMS 0.31 8.41 0.32 2.74e-16 Metabolite levels (X-11787); BRCA cis rs3772130 0.962 rs13065245 chr3:121566729 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.57 9.94 0.37 9.38e-22 Cognitive performance; BRCA cis rs6942756 0.806 rs1880854 chr7:128949748 G/T cg02491457 chr7:128862824 NA 0.56 12.02 0.43 3.83e-30 White matter hyperintensity burden; BRCA trans rs7824557 0.737 rs2293855 chr8:11177410 G/A cg06636001 chr8:8085503 FLJ10661 0.55 10.35 0.38 2.56e-23 Retinal vascular caliber; BRCA cis rs1784581 0.894 rs1784594 chr6:162382734 A/G cg17173639 chr6:162384350 PARK2 -0.43 -10.48 -0.38 8.03e-24 Itch intensity from mosquito bite; BRCA cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.9 0.43 1.2e-29 Hip circumference adjusted for BMI; BRCA cis rs10838687 0.736 rs7120158 chr11:47265194 G/C cg25783544 chr11:47291846 MADD 0.42 7.87 0.3 1.57e-14 Proinsulin levels; BRCA cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg05025164 chr4:1340916 KIAA1530 0.41 9.27 0.34 2.75e-19 Longevity; BRCA cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg01181863 chr3:195395398 SDHAP2 -0.46 -8.01 -0.3 5.54e-15 Pancreatic cancer; BRCA cis rs17270561 0.697 rs9366633 chr6:25838054 A/G cg16482183 chr6:26056742 HIST1H1C 0.51 10.23 0.38 7.31e-23 Iron status biomarkers; BRCA cis rs2839186 0.967 rs17176131 chr21:47705237 T/C cg12379764 chr21:47803548 PCNT -0.37 -7.91 -0.3 1.11e-14 Testicular germ cell tumor; BRCA cis rs61931739 0.517 rs12815556 chr12:34319670 G/A cg06521331 chr12:34319734 NA -0.65 -11.95 -0.43 7.75e-30 Morning vs. evening chronotype; BRCA cis rs2455799 0.613 rs6802048 chr3:15883933 A/G cg16303742 chr3:15540471 COLQ -0.38 -9.27 -0.34 2.85e-19 Mean platelet volume; BRCA cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg21573476 chr21:45109991 RRP1B -0.47 -11.63 -0.42 1.74e-28 Mean corpuscular volume; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.93 -15.83 -0.53 7.73e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg22920501 chr2:26401640 FAM59B 0.63 10.89 0.4 1.81e-25 Gut microbiome composition (summer); BRCA cis rs514406 0.729 rs534070 chr1:53308858 T/G cg08859206 chr1:53392774 SCP2 -0.59 -12.76 -0.45 2.13e-33 Monocyte count; BRCA cis rs2279817 1.000 rs905389 chr1:18021406 T/C cg21791023 chr1:18019539 ARHGEF10L 0.54 16.44 0.55 6.25e-51 Neuroticism; BRCA cis rs1011018 0.628 rs10230692 chr7:139421180 A/G cg03224163 chr7:139420300 HIPK2 -0.54 -9.18 -0.34 5.9e-19 Systolic blood pressure; BRCA cis rs62402013 1 rs62402013 chr6:26915000 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.29 0.31 6.5e-16 Schizophrenia; BRCA cis rs4930561 0.690 rs6591334 chr11:67924559 A/G cg04465784 chr11:67976953 SUV420H1 -0.27 -8.71 -0.33 2.62e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg14196790 chr5:131705035 SLC22A5 0.35 9.27 0.34 2.93e-19 Breast cancer; BRCA cis rs4819052 0.679 rs2838859 chr21:46684517 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.47 10.35 0.38 2.49e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.51 -0.35 3.95e-20 Total body bone mineral density; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg04025307 chr7:1156635 C7orf50 0.57 13.32 0.47 6.41e-36 Longevity;Endometriosis; BRCA cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg05283184 chr6:79620031 NA -0.43 -11.05 -0.4 4.25e-26 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs2259873 chr20:25280781 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.2e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4642101 0.618 rs9877079 chr3:12821287 A/G cg05775895 chr3:12838266 CAND2 0.38 8.37 0.31 3.64e-16 QRS complex (12-leadsum); BRCA cis rs7727544 0.735 rs273914 chr5:131660431 A/T cg07395648 chr5:131743802 NA -0.36 -9.09 -0.34 1.25e-18 Blood metabolite levels; BRCA cis rs16976116 0.901 rs1061873 chr15:55496756 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9467773 1.000 rs767471 chr6:26557854 C/T cg11502198 chr6:26597334 ABT1 0.48 9.62 0.36 1.45e-20 Intelligence (multi-trait analysis); BRCA cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg24692254 chr21:30365293 RNF160 -0.47 -10.25 -0.38 6.31e-23 Dental caries; BRCA cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg08807892 chr2:162101083 NA 0.72 16.41 0.54 9.16e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs1018836 0.923 rs11784529 chr8:91640956 C/A cg16814680 chr8:91681699 NA -0.57 -12.24 -0.44 4.44e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.69 14.03 0.49 3.53e-39 Lymphocyte counts; BRCA trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg25214090 chr10:38739885 LOC399744 0.52 11.67 0.42 1.18e-28 Corneal astigmatism; BRCA cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg01483505 chr11:975446 AP2A2 0.35 9.39 0.35 1.06e-19 Alzheimer's disease (late onset); BRCA cis rs7727544 0.684 rs274567 chr5:131714409 C/T cg24060327 chr5:131705240 SLC22A5 0.46 9.41 0.35 9e-20 Blood metabolite levels; BRCA cis rs2304069 0.601 rs216143 chr5:149444147 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.61 12.83 0.45 1.13e-33 HIV-1 control; BRCA cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg11279151 chr3:101281821 RG9MTD1 -0.49 -9.9 -0.36 1.32e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1003719 0.708 rs8126491 chr21:38551219 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg01884057 chr2:25150051 NA -0.32 -8.57 -0.32 7.51e-17 Body mass index; BRCA cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg06671706 chr8:8559999 CLDN23 0.45 8.63 0.32 4.94e-17 Obesity-related traits; BRCA cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.73 0.71 9.83e-101 Chronic sinus infection; BRCA cis rs17401966 0.838 rs7553228 chr1:10350438 G/C cg03954927 chr1:10346856 KIF1B 0.44 13.78 0.48 5.15e-38 Hepatocellular carcinoma; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg03188948 chr7:1209495 NA 0.45 8.62 0.32 5.4e-17 Longevity;Endometriosis; BRCA cis rs11098499 0.754 rs7672594 chr4:120248543 A/C cg09307838 chr4:120376055 NA 0.64 14.09 0.49 1.94e-39 Corneal astigmatism; BRCA cis rs27434 0.583 rs151911 chr5:96157084 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.8 -0.45 1.52e-33 Ankylosing spondylitis; BRCA cis rs1003719 0.715 rs2051398 chr21:38550258 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 14.67 0.5 3.48e-42 Eye color traits; BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg00106254 chr7:1943704 MAD1L1 0.45 12.55 0.44 1.85e-32 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg23711669 chr6:146136114 FBXO30 -0.74 -15.1 -0.51 2.86e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs6840360 0.532 rs4235221 chr4:152511193 C/T cg22705602 chr4:152727874 NA -0.33 -8.22 -0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs61931739 0.534 rs11052974 chr12:34029877 T/G cg06521331 chr12:34319734 NA -0.62 -11.28 -0.41 5.11e-27 Morning vs. evening chronotype; BRCA cis rs708547 0.647 rs1718878 chr4:57876955 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.87 0.36 1.76e-21 Response to bleomycin (chromatid breaks); BRCA cis rs8016982 0.662 rs7148100 chr14:81678096 A/G cg01989461 chr14:81687754 GTF2A1 0.47 8.58 0.32 6.97e-17 Schizophrenia; BRCA cis rs911119 1.000 rs3787498 chr20:23616781 C/T cg16589663 chr20:23618590 CST3 0.46 8.66 0.32 3.93e-17 Chronic kidney disease; BRCA cis rs6545883 0.894 rs9677047 chr2:61585295 C/G cg15711740 chr2:61764176 XPO1 0.51 12.45 0.44 5.07e-32 Tuberculosis; BRCA cis rs7677751 0.806 rs1800813 chr4:55094467 G/A cg17187183 chr4:55093834 PDGFRA 0.45 8.63 0.32 4.93e-17 Corneal astigmatism; BRCA cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg24692254 chr21:30365293 RNF160 -0.79 -22.61 -0.67 1.3e-83 Dental caries; BRCA cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.09 0.43 1.83e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7903847 0.642 rs9888026 chr10:99159869 G/T cg20016023 chr10:99160130 RRP12 0.26 8.36 0.31 3.99e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs2880765 0.743 rs8039631 chr15:86007931 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.37 -0.31 3.57e-16 Coronary artery disease; BRCA cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg12927641 chr6:109611667 NA -0.42 -10.87 -0.4 2.22e-25 Reticulocyte fraction of red cells; BRCA trans rs2018683 0.707 rs1021691 chr7:28974496 C/T cg19402173 chr7:128379420 CALU -0.42 -9.92 -0.37 1.1e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs208520 0.874 rs208473 chr6:66917265 G/C cg07460842 chr6:66804631 NA -0.89 -15.64 -0.53 6.62e-47 Exhaled nitric oxide output; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11141652 chr22:24348549 GSTTP1 -0.38 -7.81 -0.3 2.41e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7677751 0.806 rs6554163 chr4:55102559 A/T cg17187183 chr4:55093834 PDGFRA 0.45 9.5 0.35 4.01e-20 Corneal astigmatism; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.71 -0.42 8.23e-29 Lymphocyte counts; BRCA cis rs7575217 0.682 rs4851401 chr2:101700518 T/C cg23907051 chr2:101730305 TBC1D8 0.2 7.92 0.3 1.08e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs2742234 0.910 rs2505511 chr10:43641029 T/A cg15436174 chr10:43711423 RASGEF1A -0.43 -9.0 -0.34 2.49e-18 Hirschsprung disease; BRCA cis rs9527 0.615 rs1556960 chr10:104726673 A/G cg04362960 chr10:104952993 NT5C2 0.45 10.34 0.38 2.75e-23 Arsenic metabolism; BRCA cis rs311392 1.000 rs311392 chr8:55084782 A/G cg11783602 chr8:55087084 NA -0.33 -9.98 -0.37 7e-22 Pelvic organ prolapse (moderate/severe); BRCA cis rs7524258 0.868 rs7538921 chr1:7267007 T/C cg07173049 chr1:7289937 CAMTA1 0.54 13.01 0.46 1.63e-34 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg21545522 chr1:205238299 TMCC2 0.39 8.25 0.31 9.23e-16 Mean corpuscular volume;Mean platelet volume; BRCA trans rs60843830 1.000 rs17714252 chr2:285471 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 13.71 0.48 1.05e-37 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs672059 0.934 rs6703054 chr1:183155778 A/C ch.1.3577855R chr1:183094577 LAMC1 0.38 8.64 0.32 4.44e-17 Hypertriglyceridemia; BRCA cis rs4363385 0.782 rs4845515 chr1:153003871 G/T cg25856811 chr1:152973957 SPRR3 -0.31 -8.34 -0.31 4.49e-16 Inflammatory skin disease; BRCA cis rs7605378 1.000 rs769954 chr2:200692159 C/G cg23649088 chr2:200775458 C2orf69 -0.47 -9.6 -0.35 1.83e-20 Osteoporosis; BRCA trans rs208520 0.690 rs12213561 chr6:66705646 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 20.27 0.63 6.67e-71 Exhaled nitric oxide output; BRCA cis rs698833 0.886 rs2241871 chr2:44548613 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.1 0.37 2.4e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.11 0.31 2.51e-15 Tonsillectomy; BRCA trans rs7613875 0.600 rs2624848 chr3:50165101 T/C cg21659725 chr3:3221576 CRBN -0.36 -8.54 -0.32 9.92e-17 Body mass index; BRCA cis rs2032447 0.641 rs442601 chr6:25934524 G/A cg03517284 chr6:25882590 NA -0.48 -10.3 -0.38 3.96e-23 Intelligence (multi-trait analysis); BRCA cis rs236352 0.576 rs2116447 chr6:36837364 T/C cg10099585 chr6:36853529 C6orf89 -0.34 -7.87 -0.3 1.49e-14 Heart rate; BRCA cis rs208520 0.526 rs9354366 chr6:66788559 C/T cg07460842 chr6:66804631 NA -1.18 -38.99 -0.84 3.98e-171 Exhaled nitric oxide output; BRCA cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg24558204 chr6:135376177 HBS1L 0.59 15.99 0.53 1.14e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9399135 0.967 rs2327578 chr6:135329969 C/T cg24558204 chr6:135376177 HBS1L 0.46 12.61 0.45 9.93e-33 Red blood cell count; BRCA cis rs16958440 0.867 rs57744138 chr18:44700482 A/C cg17192377 chr18:44677553 HDHD2 0.99 13.47 0.47 1.43e-36 Sitting height ratio; BRCA cis rs10754283 0.967 rs10737707 chr1:90119304 A/G cg21401794 chr1:90099060 LRRC8C 0.48 11.68 0.42 1.04e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7267979 0.934 rs2261753 chr20:25262291 G/A cg08601574 chr20:25228251 PYGB 0.37 8.8 0.33 1.23e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12950390 0.853 rs17700008 chr17:45863591 A/C cg03474202 chr17:45855739 NA 0.45 11.88 0.43 1.56e-29 IgG glycosylation; BRCA cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.51 0.32 1.25e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs490234 0.812 rs4838284 chr9:128446365 G/T cg14078157 chr9:128172775 NA -0.42 -9.51 -0.35 3.9e-20 Mean arterial pressure; BRCA cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.92 0.4 1.43e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs13102973 0.965 rs4629509 chr4:135872410 C/T cg14419869 chr4:135874104 NA -0.59 -12.98 -0.46 2.36e-34 Subjective well-being; BRCA cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg11843238 chr5:131593191 PDLIM4 0.35 7.86 0.3 1.62e-14 Breast cancer; BRCA cis rs8180040 0.681 rs9818382 chr3:47193034 C/T cg16586182 chr3:47516702 SCAP -0.56 -12.49 -0.44 3.39e-32 Colorectal cancer; BRCA cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.41e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs56104184 0.775 rs73061699 chr19:49400511 T/C cg21252483 chr19:49399788 TULP2 -0.51 -10.86 -0.39 2.53e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs57221529 0.766 rs4957053 chr5:575927 T/C cg09021430 chr5:549028 NA -0.68 -14.27 -0.49 2.58e-40 Lung disease severity in cystic fibrosis; BRCA cis rs877282 0.700 rs816311 chr10:796490 C/A cg17470449 chr10:769945 NA 0.41 7.83 0.3 2.04e-14 Uric acid levels; BRCA cis rs10193935 0.901 rs13426988 chr2:42604081 G/A cg27598129 chr2:42591480 NA -1.0 -14.8 -0.51 7.67e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg20701182 chr2:24300061 SF3B14 0.55 8.2 0.31 1.35e-15 Lymphocyte counts; BRCA cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg01483505 chr11:975446 AP2A2 0.33 9.02 0.34 2.22e-18 Alzheimer's disease (late onset); BRCA cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg10802521 chr3:52805072 NEK4 -0.3 -7.82 -0.3 2.16e-14 Electroencephalogram traits; BRCA trans rs637571 0.522 rs556643 chr11:65733289 C/T cg17712092 chr4:129076599 LARP1B 0.51 12.34 0.44 1.51e-31 Eosinophil percentage of white cells; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.81 -13.66 -0.48 1.94e-37 Platelet count; BRCA cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.36 0.41 2.22e-27 Coronary artery disease; BRCA cis rs10924970 0.870 rs12095886 chr1:235432249 A/G cg26050004 chr1:235667680 B3GALNT2 0.34 8.52 0.32 1.16e-16 Asthma; BRCA cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg10193763 chr2:225306901 NA 0.3 7.81 0.3 2.28e-14 IgE levels in asthmatics (D.p. specific); BRCA cis rs11051970 0.545 rs2728681 chr12:32582977 T/C cg24626660 chr12:32551988 NA 0.3 8.78 0.33 1.45e-17 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg18252515 chr7:66147081 NA -0.54 -11.01 -0.4 6.36e-26 Corneal structure; BRCA cis rs16976116 0.901 rs62020114 chr15:55501116 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs1814175 0.533 rs4528310 chr11:49983106 C/T cg15704280 chr7:45808275 SEPT13 0.62 8.68 0.32 3.19e-17 Height; BRCA cis rs9790314 0.613 rs11716265 chr3:160602111 A/G cg03342759 chr3:160939853 NMD3 -0.42 -7.92 -0.3 1.04e-14 Morning vs. evening chronotype; BRCA cis rs6963495 0.818 rs9769403 chr7:105163091 G/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.61 -0.32 5.63e-17 Colorectal cancer; BRCA cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg24110177 chr3:50126178 RBM5 -0.37 -9.91 -0.36 1.26e-21 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.31e-54 Bladder cancer; BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.87 0.6 1.93e-63 Alzheimer's disease; BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.42 8.59 0.32 6.9e-17 Lymphocyte counts; BRCA trans rs11039798 1.000 rs11039978 chr11:48760237 A/G cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.69 0.57 2.73e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs738322 0.967 rs4380 chr22:38569529 T/C cg25457927 chr22:38595422 NA -0.31 -11.65 -0.42 1.41e-28 Cutaneous nevi; BRCA trans rs1997103 0.911 rs11238361 chr7:55395981 A/G cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2274273 0.837 rs7146748 chr14:55747086 G/A cg04306507 chr14:55594613 LGALS3 0.33 9.13 0.34 8.8e-19 Protein biomarker; BRCA cis rs6545883 0.524 rs2593631 chr2:61572286 A/G cg15711740 chr2:61764176 XPO1 0.32 7.81 0.3 2.29e-14 Tuberculosis; BRCA cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg16339924 chr4:17578868 LAP3 0.63 15.82 0.53 8.4e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg05985134 chr18:33552581 C18orf21 -0.68 -12.63 -0.45 8.42e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg17971929 chr21:40555470 PSMG1 -0.62 -14.48 -0.5 2.58e-41 Cognitive function; BRCA cis rs6912958 0.781 rs13193380 chr6:88297057 G/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.53 -0.32 1.1e-16 Monocyte percentage of white cells; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.37 0.65 7.12e-77 Gut microbiome composition (summer); BRCA cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg04553112 chr3:125709451 NA -0.55 -8.44 -0.32 2.1e-16 Blood pressure (smoking interaction); BRCA cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg06808227 chr14:105710500 BRF1 -0.79 -15.91 -0.53 2.86e-48 Mean platelet volume;Platelet distribution width; BRCA cis rs2070433 0.752 rs11701058 chr21:47776382 T/C cg05998816 chr21:47859926 PCNT 0.36 8.17 0.31 1.65e-15 Lymphocyte counts; BRCA cis rs919433 0.679 rs10931787 chr2:198520615 A/G cg00792783 chr2:198669748 PLCL1 0.39 9.02 0.34 2.24e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg22834771 chr12:69754056 YEATS4 -0.36 -9.03 -0.34 2.08e-18 Blood protein levels; BRCA cis rs9290065 0.519 rs10513560 chr3:160710798 C/T cg03342759 chr3:160939853 NMD3 -0.47 -9.64 -0.36 1.24e-20 Kawasaki disease; BRCA trans rs7618501 0.699 rs6446187 chr3:49907111 C/A cg21659725 chr3:3221576 CRBN 0.53 13.7 0.48 1.25e-37 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg26384229 chr12:38710491 ALG10B 0.66 15.27 0.52 4.12e-45 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.29 0.56 3.24e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs936229 0.861 rs7180484 chr15:75115416 G/T cg10253484 chr15:75165896 SCAMP2 0.52 10.01 0.37 5.4e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg11502198 chr6:26597334 ABT1 -0.49 -10.35 -0.38 2.66e-23 Intelligence (multi-trait analysis); BRCA cis rs634534 0.562 rs661335 chr11:65754061 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.59 13.3 0.47 8.2e-36 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg23978390 chr7:1156363 C7orf50 0.4 7.93 0.3 9.97e-15 Bronchopulmonary dysplasia; BRCA cis rs11098499 0.779 rs7699346 chr4:120310542 C/T cg09307838 chr4:120376055 NA 0.71 15.07 0.51 3.93e-44 Corneal astigmatism; BRCA cis rs11098499 0.820 rs12503082 chr4:120284317 A/G cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs35110281 0.659 rs11909064 chr21:45092095 G/C cg21573476 chr21:45109991 RRP1B -0.47 -12.13 -0.43 1.22e-30 Mean corpuscular volume; BRCA cis rs11190604 1.000 rs12219789 chr10:102213778 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.15 0.4 1.7e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg04944784 chr2:26401820 FAM59B 0.96 16.57 0.55 1.43e-51 Gut microbiome composition (summer); BRCA trans rs66887589 0.967 rs2892869 chr4:120521297 T/C cg25214090 chr10:38739885 LOC399744 -0.35 -7.92 -0.3 1.08e-14 Diastolic blood pressure; BRCA cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg01283332 chr5:1856932 NA -0.35 -8.6 -0.32 6.29e-17 Cardiovascular disease risk factors; BRCA trans rs17685 0.753 rs11972240 chr7:75694079 A/C cg19862616 chr7:65841803 NCRNA00174 0.85 28.13 0.74 6.66e-114 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14240646 chr10:27532245 ACBD5 0.64 9.43 0.35 7.69e-20 Breast cancer; BRCA cis rs67460515 0.926 rs11715591 chr3:161043137 C/T cg04691961 chr3:161091175 C3orf57 -0.38 -8.05 -0.3 4.06e-15 Parkinson's disease; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg10862848 chr6:42927986 GNMT -0.36 -15.1 -0.51 2.83e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1538970 1.000 rs4520450 chr1:45834773 A/G cg05343316 chr1:45956843 TESK2 0.56 11.47 0.41 7.95e-28 Platelet count; BRCA cis rs11971779 0.680 rs7788777 chr7:139055193 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg26031613 chr14:104095156 KLC1 0.73 15.88 0.53 3.91e-48 Body mass index; BRCA cis rs1568889 0.838 rs11030265 chr11:28296168 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 19.44 0.61 1.67e-66 Bipolar disorder; BRCA cis rs7707921 0.522 rs9293290 chr5:81474225 A/T cg15871215 chr5:81402204 ATG10 -0.36 -9.14 -0.34 8.47e-19 Breast cancer; BRCA cis rs6138458 1.000 rs7268095 chr20:24972333 C/T cg06937882 chr20:24974362 C20orf3 -0.46 -9.02 -0.34 2.15e-18 Blood protein levels; BRCA cis rs10754283 0.967 rs6657988 chr1:90106745 G/C cg21401794 chr1:90099060 LRRC8C 0.46 11.13 0.4 2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6987853 0.736 rs35295075 chr8:42428852 A/G cg09913449 chr8:42400586 C8orf40 0.41 9.2 0.34 5.12e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.94 0.43 8.34e-30 Tonsillectomy; BRCA cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs7727544 0.647 rs7721882 chr5:131418948 A/G cg14196790 chr5:131705035 SLC22A5 0.37 9.07 0.34 1.46e-18 Blood metabolite levels; BRCA cis rs7647973 0.731 rs13084037 chr3:49214066 G/A cg06212747 chr3:49208901 KLHDC8B 0.64 10.91 0.4 1.52e-25 Menarche (age at onset); BRCA cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg05084668 chr3:125655381 ALG1L 0.46 7.83 0.3 2.01e-14 Blood pressure (smoking interaction); BRCA cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg12935359 chr14:103987150 CKB -0.59 -14.22 -0.49 4.73e-40 Bone mineral density; BRCA cis rs10129255 0.500 rs8022547 chr14:107190222 A/T cg07958169 chr14:107095056 NA -0.39 -8.46 -0.32 1.84e-16 Kawasaki disease; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg11814155 chr7:99998594 ZCWPW1 0.45 7.89 0.3 1.36e-14 Platelet count; BRCA cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.05 0.3 4.09e-15 Aortic root size; BRCA cis rs67460515 0.926 rs66508859 chr3:160946351 C/T cg17135325 chr3:160939158 NMD3 0.39 7.93 0.3 9.79e-15 Parkinson's disease; BRCA cis rs1008375 0.966 rs6449325 chr4:17699509 C/T cg04450456 chr4:17643702 FAM184B -0.31 -8.64 -0.32 4.65e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg06784218 chr1:46089804 CCDC17 -0.42 -9.58 -0.35 2.19e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg04727924 chr7:799746 HEATR2 -0.52 -9.9 -0.36 1.39e-21 Cerebrospinal P-tau181p levels; BRCA cis rs7587476 0.862 rs13001462 chr2:215678346 G/A cg04004882 chr2:215674386 BARD1 0.65 12.12 0.43 1.41e-30 Neuroblastoma; BRCA cis rs2204008 0.577 rs11520050 chr12:38051839 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 2.99e-22 Bladder cancer; BRCA cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg11833968 chr6:79620685 NA -0.44 -9.88 -0.36 1.67e-21 Intelligence (multi-trait analysis); BRCA cis rs6066835 1.000 rs6125446 chr20:47348161 C/G cg18078177 chr20:47281410 PREX1 0.69 8.61 0.32 5.58e-17 Multiple myeloma; BRCA trans rs35110281 0.627 rs1436291 chr21:44965485 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.06 0.37 3.5e-22 Mean corpuscular volume; BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg02951883 chr7:2050386 MAD1L1 -0.5 -11.66 -0.42 1.23e-28 Schizophrenia; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg04234412 chr22:24373322 LOC391322 -0.62 -15.57 -0.52 1.38e-46 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7123876 0.553 rs12099027 chr11:72433920 A/G cg04827223 chr11:72435913 ARAP1 -0.57 -14.8 -0.51 7.67e-43 Body mass index; BRCA trans rs11764590 0.950 rs55683212 chr7:2078855 G/C cg11693508 chr17:37793320 STARD3 0.57 10.87 0.4 2.23e-25 Neuroticism; BRCA cis rs56804039 1.000 rs56804039 chr8:8381029 C/G cg06636001 chr8:8085503 FLJ10661 -0.57 -9.32 -0.35 1.91e-19 Cervical cancer; BRCA cis rs758324 0.853 rs6882899 chr5:131172467 G/C cg06307176 chr5:131281290 NA 0.52 10.15 0.37 1.55e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs73242632 0.881 rs55734441 chr4:57833717 G/A cg20415529 chr4:57845134 POLR2B;C4orf14 0.7 8.62 0.32 5.37e-17 Congenital heart disease (maternal effect); BRCA cis rs912057 0.833 rs1294421 chr6:6743149 A/C cg06612196 chr6:6737390 NA 0.39 8.82 0.33 1.05e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs911119 1.000 rs3827143 chr20:23619617 A/G cg16589663 chr20:23618590 CST3 0.47 8.81 0.33 1.2e-17 Chronic kidney disease; BRCA cis rs4730250 0.707 rs257378 chr7:106801395 C/G cg02696742 chr7:106810147 HBP1 -0.62 -9.76 -0.36 4.45e-21 Osteoarthritis; BRCA cis rs875971 0.502 rs11769702 chr7:65720516 A/C cg11764359 chr7:65958608 NA 0.63 10.79 0.39 4.96e-25 Aortic root size; BRCA cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg16482183 chr6:26056742 HIST1H1C 0.56 11.8 0.42 3.38e-29 Height; BRCA cis rs11190604 1.000 rs2295773 chr10:102265815 A/G cg07080220 chr10:102295463 HIF1AN 0.61 14.51 0.5 1.97e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg03146154 chr1:46216737 IPP 0.52 11.6 0.42 2.36e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3008870 0.792 rs72673729 chr1:67441673 T/TG cg08660285 chr1:67390436 MIER1;WDR78 -0.98 -21.6 -0.65 3.93e-78 Lymphocyte percentage of white cells; BRCA cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.79 -0.42 3.6e-29 Alcohol dependence; BRCA cis rs73036520 0.846 rs17356664 chr19:45740771 C/T cg01416317 chr19:45737208 EXOC3L2 0.39 8.08 0.3 3.35e-15 Monocyte percentage of white cells; BRCA cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg14530993 chr4:882597 GAK 0.55 9.95 0.37 8.79e-22 Intelligence (multi-trait analysis); BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg02951883 chr7:2050386 MAD1L1 -0.49 -11.19 -0.4 1.1e-26 Schizophrenia; BRCA cis rs4595586 0.525 rs1878227 chr12:39355719 A/T cg26384229 chr12:38710491 ALG10B 0.54 11.47 0.41 7.77e-28 Morning vs. evening chronotype; BRCA cis rs854765 0.647 rs854790 chr17:18028318 C/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.4 10.87 0.4 2.2e-25 Total body bone mineral density; BRCA cis rs73198271 0.563 rs3748143 chr8:8655237 A/G cg01851573 chr8:8652454 MFHAS1 -0.42 -7.83 -0.3 2.09e-14 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.77 -0.42 4.23e-29 Glomerular filtration rate (creatinine); BRCA cis rs1451375 0.642 rs6963996 chr7:50559300 T/C cg18232548 chr7:50535776 DDC -0.42 -8.87 -0.33 7.06e-18 Malaria; BRCA cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -12.13 -0.43 1.27e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs614226 0.938 rs12857 chr12:120933946 T/G cg01236616 chr12:121019343 POP5 1.2 25.9 0.72 1.14e-101 Type 1 diabetes nephropathy; BRCA cis rs9287719 0.967 rs2010073 chr2:10736478 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs12579753 1.000 rs12827923 chr12:82242067 G/A cg07988820 chr12:82153109 PPFIA2 -0.65 -10.48 -0.38 7.7e-24 Resting heart rate; BRCA cis rs208520 0.690 rs207081 chr6:66773742 A/G cg07460842 chr6:66804631 NA -1.03 -20.44 -0.63 7.46e-72 Exhaled nitric oxide output; BRCA cis rs1595825 0.891 rs1030796 chr2:198674673 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.33 -0.31 4.87e-16 Ulcerative colitis; BRCA trans rs2204008 0.639 rs7311462 chr12:38278130 G/A cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs600626 0.636 rs10899109 chr11:75451201 G/A cg24262691 chr11:75473276 NA 0.47 7.85 0.3 1.75e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); BRCA cis rs3857067 0.806 rs28408270 chr4:95114572 G/T cg11021082 chr4:95130006 SMARCAD1 -0.41 -9.74 -0.36 5.47e-21 QT interval; BRCA cis rs2880765 0.566 rs55899824 chr15:86004091 C/T cg10818794 chr15:86012489 AKAP13 -0.42 -11.41 -0.41 1.46e-27 Coronary artery disease; BRCA cis rs13082711 0.911 rs2131205 chr3:27428501 A/G cg02860705 chr3:27208620 NA 0.53 10.32 0.38 3.48e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs61931739 0.534 rs12831685 chr12:34038392 C/T cg06521331 chr12:34319734 NA -0.63 -12.47 -0.44 4.13e-32 Morning vs. evening chronotype; BRCA cis rs11190604 1.000 rs2495745 chr10:102329075 A/G cg07080220 chr10:102295463 HIF1AN 0.53 12.26 0.44 3.67e-31 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg22963979 chr7:1858916 MAD1L1 -0.46 -9.26 -0.34 3.12e-19 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg17691542 chr6:26056736 HIST1H1C 0.49 10.3 0.38 3.94e-23 Height; BRCA cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg14983838 chr19:29218262 NA 0.54 10.09 0.37 2.65e-22 Methadone dose in opioid dependence; BRCA cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg03161606 chr19:29218774 NA 0.44 7.89 0.3 1.33e-14 Methadone dose in opioid dependence; BRCA cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg12463550 chr7:65579703 CRCP -0.37 -7.96 -0.3 8.11e-15 Aortic root size; BRCA cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 8.8 0.33 1.25e-17 Cognitive ability; BRCA cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg01884057 chr2:25150051 NA 0.31 8.1 0.31 2.84e-15 Body mass index; BRCA trans rs11764590 0.715 rs9639202 chr7:2087315 G/A cg11693508 chr17:37793320 STARD3 0.52 9.19 0.34 5.36e-19 Neuroticism; BRCA cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg07493874 chr5:1342172 CLPTM1L -0.53 -15.14 -0.51 1.73e-44 Lung cancer; BRCA cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg08213375 chr14:104286397 PPP1R13B 0.63 18.11 0.58 1.69e-59 Schizophrenia; BRCA cis rs495337 0.760 rs2745078 chr20:48525460 C/T cg17835207 chr20:48524531 SPATA2 -0.68 -16.82 -0.55 8.02e-53 Psoriasis; BRCA cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11644478 chr21:40555479 PSMG1 -0.67 -15.11 -0.51 2.41e-44 Cognitive function; BRCA cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg24642844 chr7:1081250 C7orf50 -0.92 -12.25 -0.44 3.88e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg06784218 chr1:46089804 CCDC17 0.52 12.72 0.45 3.23e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs6952808 0.531 rs3800922 chr7:2184505 A/G cg04565464 chr8:145669602 NFKBIL2 0.4 8.75 0.33 1.85e-17 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs2286885 1.000 rs741025 chr9:129251792 C/T cg15282417 chr9:129245246 FAM125B 0.3 7.81 0.3 2.28e-14 Intraocular pressure; BRCA cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg14582100 chr15:45693742 SPATA5L1 -0.36 -11.76 -0.42 4.68e-29 Homoarginine levels; BRCA cis rs7131987 0.903 rs10843367 chr12:29408380 G/A cg09582351 chr12:29534625 ERGIC2 -0.49 -11.77 -0.42 4.32e-29 QT interval; BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg27170947 chr2:26402098 FAM59B -0.66 -11.43 -0.41 1.22e-27 Gut microbiome composition (summer); BRCA trans rs6076960 0.629 rs6054024 chr20:6229282 A/C cg17788362 chr6:86352627 SYNCRIP 0.4 8.08 0.3 3.17e-15 Smooth-surface caries; BRCA cis rs7737355 0.738 rs3776016 chr5:130855352 C/T cg06307176 chr5:131281290 NA 0.45 9.86 0.36 1.88e-21 Life satisfaction; BRCA cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg12373951 chr3:133503437 NA 0.53 12.5 0.44 3.06e-32 Iron status biomarkers; BRCA cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22307029 chr19:49891270 CCDC155 0.68 12.44 0.44 5.71e-32 Multiple sclerosis; BRCA cis rs6121246 0.559 rs6060919 chr20:30331922 A/T cg21427119 chr20:30132790 HM13 -0.35 -8.04 -0.3 4.42e-15 Mean corpuscular hemoglobin; BRCA cis rs9467711 0.591 rs13195692 chr6:26044373 C/T cg08501292 chr6:25962987 TRIM38 0.58 7.87 0.3 1.52e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs7666738 0.830 rs7696715 chr4:98938486 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg24642439 chr20:33292090 TP53INP2 -0.7 -16.31 -0.54 2.91e-50 Coronary artery disease; BRCA cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg08564027 chr20:61660810 NA 0.9 23.51 0.68 1.56e-88 Prostate cancer (SNP x SNP interaction); BRCA cis rs12620038 0.525 rs7598661 chr2:47468955 C/T cg13204236 chr2:47476732 NA 0.36 9.9 0.36 1.38e-21 Survival in pancreatic cancer; BRCA cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.62 10.26 0.38 5.56e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.46 10.01 0.37 5.06e-22 Cognitive ability; BRCA cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg11062466 chr8:58055876 NA 0.41 8.0 0.3 5.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.712 rs4803263 chr19:38066782 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs6500602 0.819 rs3747580 chr16:4455675 G/A cg08645402 chr16:4508243 NA 0.39 8.42 0.32 2.56e-16 Schizophrenia; BRCA trans rs1005277 0.529 rs1780125 chr10:38531376 A/G cg17830980 chr10:43048298 ZNF37B -0.52 -12.61 -0.45 9.81e-33 Extrinsic epigenetic age acceleration; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg22907277 chr7:1156413 C7orf50 0.59 9.1 0.34 1.11e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs26949 0.511 rs2898287 chr5:59884233 C/G cg02684056 chr5:59996105 DEPDC1B -0.4 -9.77 -0.36 4.03e-21 Intelligence (multi-trait analysis); BRCA cis rs7617773 0.851 rs7647817 chr3:48236507 G/A cg11946769 chr3:48343235 NME6 0.67 13.96 0.48 7.95e-39 Coronary artery disease; BRCA cis rs250677 0.522 rs10038913 chr5:148354224 A/G cg12140854 chr5:148520817 ABLIM3 0.41 8.24 0.31 9.73e-16 Breast cancer; BRCA cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.46e-19 Bipolar disorder; BRCA cis rs7639513 0.737 rs13070228 chr3:12706914 G/A cg23032965 chr3:12705835 RAF1 0.71 15.83 0.53 7.73e-48 Itch intensity from mosquito bite; BRCA cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.51 0.35 3.89e-20 Motion sickness; BRCA cis rs3784262 0.869 rs4646628 chr15:58255282 T/C cg12031962 chr15:58353849 ALDH1A2 -0.44 -11.91 -0.43 1.12e-29 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -8.25 -0.31 9.4e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg00684032 chr4:1343700 KIAA1530 0.52 12.41 0.44 8.07e-32 Obesity-related traits; BRCA cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg21782813 chr7:2030301 MAD1L1 0.4 10.66 0.39 1.55e-24 Bipolar disorder and schizophrenia; BRCA cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg10523679 chr1:76189770 ACADM -0.47 -8.98 -0.33 3.02e-18 Daytime sleep phenotypes; BRCA cis rs1569175 0.522 rs2202923 chr2:200879804 C/T cg23649088 chr2:200775458 C2orf69 -0.55 -8.23 -0.31 1.09e-15 Response to treatment for acute lymphoblastic leukemia; BRCA cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg05283184 chr6:79620031 NA -0.41 -10.47 -0.38 8.51e-24 Intelligence (multi-trait analysis); BRCA cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.47 -10.79 -0.39 4.77e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.12 -0.37 1.97e-22 Initial pursuit acceleration; BRCA cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg15017067 chr4:17643749 FAM184B 0.32 10.2 0.37 1.01e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -13.27 -0.46 1.17e-35 Cognitive function; BRCA cis rs7264396 0.747 rs2425151 chr20:34394541 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.74 -15.35 -0.52 1.74e-45 Total cholesterol levels; BRCA cis rs10189230 0.935 rs6731133 chr2:222359155 C/T cg14652038 chr2:222343519 EPHA4 0.49 13.66 0.48 1.9e-37 Urate levels in lean individuals; BRCA cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg21395723 chr22:39101663 GTPBP1 0.38 8.32 0.31 5.17e-16 Menopause (age at onset); BRCA cis rs34779708 0.733 rs3936502 chr10:35549218 C/T cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg11266682 chr4:10021025 SLC2A9 0.4 10.78 0.39 4.99e-25 Bone mineral density; BRCA cis rs769267 0.965 rs13964 chr19:19468710 C/G cg03709012 chr19:19516395 GATAD2A -0.75 -16.73 -0.55 2.17e-52 Tonsillectomy; BRCA cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg08085267 chr17:45401833 C17orf57 -0.69 -15.12 -0.51 2.12e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg25036284 chr2:26402008 FAM59B 0.96 15.95 0.53 1.78e-48 Gut microbiome composition (summer); BRCA cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.51 8.43 0.32 2.21e-16 Lung function (FEV1/FVC); BRCA cis rs28374715 0.578 rs17730589 chr15:41600878 T/C cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.06 -0.7 4.57e-97 Ulcerative colitis; BRCA cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg20887711 chr4:1340912 KIAA1530 0.74 15.79 0.53 1.18e-47 Longevity; BRCA cis rs2860975 0.905 rs10882516 chr10:96791217 A/C cg09036531 chr10:96991505 NA -0.39 -8.3 -0.31 6.26e-16 Immune response to smallpox vaccine (IL-6); BRCA cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg00012203 chr2:219082015 ARPC2 -0.59 -12.24 -0.44 4.06e-31 Colorectal cancer; BRCA cis rs3008870 1.000 rs2755248 chr1:67492624 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.6 0.65 4.26e-78 Lymphocyte percentage of white cells; BRCA cis rs6570726 0.791 rs7765687 chr6:145915100 A/C cg23711669 chr6:146136114 FBXO30 0.72 17.32 0.57 2.26e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs6450176 1.000 rs58369491 chr5:53297295 T/C ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.07 -0.51 3.76e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs17741873 0.779 rs4746153 chr10:75598282 G/C cg07699608 chr10:75541558 CHCHD1 0.5 8.21 0.31 1.27e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.16 0.4 1.54e-26 Electroencephalogram traits; BRCA cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg07817648 chr10:79422355 NA 0.64 12.44 0.44 5.5e-32 Bone mineral density; BRCA cis rs9831754 0.906 rs7621811 chr3:78388816 G/A cg06138941 chr3:78371609 NA -0.76 -16.59 -0.55 1.18e-51 Calcium levels; BRCA cis rs8016982 0.962 rs8007841 chr14:81647878 C/T cg01989461 chr14:81687754 GTF2A1 -0.47 -9.65 -0.36 1.12e-20 Schizophrenia; BRCA cis rs12617721 0.574 rs6542754 chr2:99025400 C/T cg10123293 chr2:99228465 UNC50 0.43 8.46 0.32 1.88e-16 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs910316 1.000 rs910316 chr14:75626042 A/C cg08847533 chr14:75593920 NEK9 0.95 24.95 0.7 1.99e-96 Height; BRCA cis rs17384381 1.000 rs12128907 chr1:85891385 A/G cg16011679 chr1:85725395 C1orf52 0.52 8.07 0.3 3.49e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3760982 0.585 rs1386502 chr19:44293356 T/C cg11993925 chr19:44307056 LYPD5 0.37 8.78 0.33 1.54e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs3741151 0.773 rs73544729 chr11:73183418 G/T cg17517138 chr11:73019481 ARHGEF17 0.88 12.43 0.44 6.17e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg18279126 chr7:2041391 MAD1L1 0.39 8.94 0.33 4.18e-18 Bipolar disorder and schizophrenia; BRCA cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg12935359 chr14:103987150 CKB 0.64 15.0 0.51 8.63e-44 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg22875332 chr1:76189707 ACADM 0.57 10.03 0.37 4.2e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg01689657 chr7:91764605 CYP51A1 0.23 8.39 0.32 3.08e-16 Breast cancer; BRCA cis rs11758351 0.660 rs55848726 chr6:26224434 T/C cg01420254 chr6:26195488 NA 0.55 8.64 0.32 4.59e-17 Gout;Renal underexcretion gout; BRCA cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg10518543 chr12:38710700 ALG10B 0.36 7.94 0.3 9.4e-15 Morning vs. evening chronotype; BRCA cis rs2806561 0.765 rs682766 chr1:23516397 C/G cg12483005 chr1:23474871 LUZP1 0.44 9.81 0.36 2.84e-21 Height; BRCA cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.43 0.54 7.51e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs9467711 0.591 rs35528636 chr6:25995701 A/C cg21479132 chr6:26055353 NA 0.57 7.97 0.3 7.48e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg04025307 chr7:1156635 C7orf50 0.59 9.46 0.35 5.6e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs708547 0.836 rs1718882 chr4:57859533 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.56 15.64 0.53 6.57e-47 Response to bleomycin (chromatid breaks); BRCA cis rs9814567 1.000 rs62271513 chr3:134298412 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.7 0.33 2.92e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg13393036 chr8:95962371 TP53INP1 -0.34 -9.29 -0.35 2.32e-19 Type 2 diabetes; BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg22920501 chr2:26401640 FAM59B 0.91 13.72 0.48 9.56e-38 Gut microbiome composition (summer); BRCA cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.26 0.56 4.56e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg15017067 chr4:17643749 FAM184B 0.34 10.78 0.39 5.23e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg18850127 chr7:39170497 POU6F2 0.59 12.81 0.45 1.33e-33 IgG glycosylation; BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg09184832 chr6:79620586 NA -0.51 -11.21 -0.41 9.87e-27 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.595 rs10503416 chr8:10987553 C/T cg15556689 chr8:8085844 FLJ10661 0.33 8.74 0.33 2.06e-17 Triglycerides; BRCA cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg06484146 chr7:12443880 VWDE -0.78 -11.09 -0.4 3.03e-26 Coronary artery disease; BRCA cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg06697600 chr4:7070879 GRPEL1 -0.52 -10.61 -0.39 2.42e-24 Monocyte percentage of white cells; BRCA cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg09469691 chr10:81107165 PPIF 0.45 9.72 0.36 6.56e-21 Height; BRCA cis rs9788682 0.747 rs7174190 chr15:78763617 C/T cg24631222 chr15:78858424 CHRNA5 0.47 9.32 0.35 1.86e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg05347473 chr6:146136440 FBXO30 0.4 8.03 0.3 4.72e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs8005677 1.000 rs2295683 chr14:23388382 A/C cg01529538 chr14:23388837 RBM23 0.42 11.48 0.41 7.01e-28 Cognitive ability (multi-trait analysis); BRCA cis rs10465746 0.809 rs2389617 chr1:84437652 A/T cg10977910 chr1:84465055 TTLL7 0.57 11.92 0.43 1.01e-29 Obesity-related traits; BRCA cis rs34779708 0.931 rs13376801 chr10:35370443 T/C cg03585969 chr10:35415529 CREM 0.48 10.22 0.37 8.56e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg24450063 chr1:156163899 SLC25A44 1.04 33.59 0.8 2.68e-143 Testicular germ cell tumor; BRCA cis rs3793683 1.000 rs3793683 chr10:134568387 G/T cg26818010 chr10:134567672 INPP5A 0.39 9.21 0.34 4.44e-19 Migraine; BRCA cis rs9300255 0.516 rs6488868 chr12:123799974 A/G cg00376283 chr12:123451042 ABCB9 0.46 11.23 0.41 7.82e-27 Neutrophil percentage of white cells; BRCA cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg03060546 chr3:49711283 APEH -0.61 -14.18 -0.49 7.36e-40 Resting heart rate; BRCA cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg27398817 chr8:82754497 SNX16 -0.37 -8.55 -0.32 8.8e-17 Diastolic blood pressure; BRCA cis rs28830936 0.966 rs890498 chr15:42111298 C/G cg17847044 chr15:42102381 MAPKBP1 -0.37 -10.22 -0.37 8.41e-23 Diastolic blood pressure; BRCA cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg20476274 chr7:133979776 SLC35B4 0.5 11.79 0.42 3.72e-29 Mean platelet volume; BRCA cis rs7772486 0.875 rs2814872 chr6:146310234 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.59 -0.32 6.86e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7833986 1.000 rs66553445 chr8:57096781 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.27 0.31 8.08e-16 Height; BRCA trans rs35110281 0.591 rs86138 chr21:44932398 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.03 0.3 4.84e-15 Mean corpuscular volume; BRCA cis rs9486715 0.867 rs6568428 chr6:96903604 A/G cg06623918 chr6:96969491 KIAA0776 0.87 24.24 0.69 1.48e-92 Headache; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg13047869 chr3:10149882 C3orf24 0.52 11.1 0.4 2.76e-26 Alzheimer's disease; BRCA cis rs7647973 0.626 rs9870858 chr3:49769071 C/T cg03060546 chr3:49711283 APEH 0.6 10.38 0.38 1.97e-23 Menarche (age at onset); BRCA trans rs17685 0.884 rs8565 chr7:75630274 T/C cg19862616 chr7:65841803 NCRNA00174 -0.65 -17.59 -0.57 8.92e-57 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg25237894 chr2:233734115 C2orf82 -0.41 -11.81 -0.42 3.12e-29 Coronary artery disease; BRCA cis rs7927592 0.956 rs12277225 chr11:68340967 T/C cg20283391 chr11:68216788 NA -0.42 -8.49 -0.32 1.44e-16 Total body bone mineral density; BRCA cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.4 0.32 3e-16 Breast cancer; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.59 -12.3 -0.44 2.25e-31 Lymphocyte counts; BRCA trans rs8002861 0.935 rs1811464 chr13:44469290 T/G cg17145862 chr1:211918768 LPGAT1 0.73 19.55 0.61 4.54e-67 Leprosy; BRCA trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg20587970 chr11:113659929 NA -1.13 -20.42 -0.63 1.05e-71 Hip circumference adjusted for BMI; BRCA cis rs11711311 1.000 rs9865965 chr3:113450495 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.35 0.31 4.2e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4653767 1.000 rs708774 chr1:226921530 C/G cg05049329 chr1:226924846 ITPKB 0.34 9.71 0.36 7.15e-21 Parkinson's disease; BRCA cis rs4363385 0.818 rs1334848 chr1:153004721 A/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.59 -0.32 6.68e-17 Inflammatory skin disease; BRCA cis rs208520 0.690 rs207096 chr6:66797287 T/C cg07460842 chr6:66804631 NA -1.0 -20.02 -0.62 1.44e-69 Exhaled nitric oxide output; BRCA cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg25237894 chr2:233734115 C2orf82 -0.36 -10.21 -0.37 8.64e-23 Coronary artery disease; BRCA cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg21433313 chr16:3507492 NAT15 -0.46 -9.8 -0.36 3.23e-21 Tuberculosis; BRCA cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg00071950 chr4:10020882 SLC2A9 -0.51 -11.87 -0.42 1.72e-29 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2243480 1.000 rs73142162 chr7:65374296 A/T cg18252515 chr7:66147081 NA -0.89 -12.28 -0.44 2.95e-31 Diabetic kidney disease; BRCA cis rs3768617 0.811 rs10911205 chr1:183009277 C/A ch.1.3577855R chr1:183094577 LAMC1 0.45 9.89 0.36 1.46e-21 Fuchs's corneal dystrophy; BRCA trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.54 0.47 6.37e-37 Morning vs. evening chronotype; BRCA trans rs61931739 0.534 rs11053010 chr12:34093228 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.42 0.35 7.88e-20 Morning vs. evening chronotype; BRCA cis rs6582630 0.563 rs923281 chr12:38590241 G/A cg26384229 chr12:38710491 ALG10B -0.46 -10.53 -0.38 5.05e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs853679 0.546 rs200950 chr6:27835772 A/G cg26587870 chr6:27730563 NA -0.55 -8.23 -0.31 1.08e-15 Depression; BRCA cis rs10504073 0.647 rs1511359 chr8:50006448 T/A cg00325661 chr8:49890786 NA 0.45 12.82 0.45 1.19e-33 Blood metabolite ratios; BRCA cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.32 -0.31 5.42e-16 Electroencephalogram traits; BRCA cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.68 -0.42 1.08e-28 Chronic sinus infection; BRCA cis rs9583531 0.509 rs12184676 chr13:111396484 A/G cg24331049 chr13:111365604 ING1 -0.65 -12.99 -0.46 2.16e-34 Coronary artery disease; BRCA cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.62 0.39 2.18e-24 Mean platelet volume; BRCA cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.54 -0.32 9.68e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg24112000 chr20:60950667 NA -0.47 -8.75 -0.33 1.94e-17 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg04709771 chr16:646395 RAB40C 0.43 10.63 0.39 1.97e-24 Height; BRCA cis rs7617773 0.817 rs6806112 chr3:48276077 A/T cg11946769 chr3:48343235 NME6 0.5 11.47 0.41 7.68e-28 Coronary artery disease; BRCA cis rs6815814 0.950 rs73236617 chr4:38793860 C/G cg02016764 chr4:38805732 TLR1 -0.64 -9.96 -0.37 7.93e-22 Breast cancer; BRCA cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.69 0.5 2.56e-42 Colorectal cancer; BRCA cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg13319975 chr6:146136371 FBXO30 -0.36 -8.08 -0.3 3.18e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.54 -9.04 -0.34 1.8e-18 Schizophrenia; BRCA cis rs7124681 0.584 rs10769285 chr11:47709212 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.52 0.35 3.42e-20 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg08045932 chr20:61659980 NA 0.49 11.48 0.41 7.01e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg04455712 chr21:45112962 RRP1B 0.46 11.68 0.42 1.07e-28 Coronary artery disease; BRCA cis rs751728 0.689 rs3763257 chr6:33773696 T/A cg15252951 chr6:33757062 LEMD2 0.38 8.67 0.32 3.45e-17 Crohn's disease; BRCA cis rs9394152 0.845 rs9380367 chr6:33474975 G/A cg13560919 chr6:33536144 NA 0.62 12.76 0.45 2.34e-33 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.34e-19 Tonsillectomy; BRCA cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg06697600 chr4:7070879 GRPEL1 -0.53 -10.82 -0.39 3.53e-25 Monocyte percentage of white cells; BRCA cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg16325326 chr1:53192061 ZYG11B 0.52 11.72 0.42 7.31e-29 Monocyte count; BRCA cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.52e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg03929089 chr4:120376271 NA -0.47 -9.04 -0.34 1.9e-18 HDL cholesterol; BRCA cis rs3008870 0.755 rs2815366 chr1:67499930 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 12.96 0.46 2.93e-34 Lymphocyte percentage of white cells; BRCA cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.13 -0.43 1.24e-30 Personality dimensions; BRCA cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg05340658 chr4:99064831 C4orf37 0.65 16.2 0.54 1.04e-49 Colonoscopy-negative controls vs population controls; BRCA trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.63e-33 Extrinsic epigenetic age acceleration; BRCA cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 12.59 0.45 1.25e-32 Personality dimensions; BRCA cis rs3796619 0.503 rs1466216 chr4:1071907 C/T cg27284194 chr4:1044797 NA -0.69 -16.07 -0.54 4.63e-49 Recombination rate (males); BRCA cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.68 14.61 0.5 6.71e-42 Total cholesterol levels; BRCA cis rs6723226 0.679 rs116617324 chr2:32622709 C/T cg02381751 chr2:32503542 YIPF4 -0.48 -10.29 -0.38 4.51e-23 Intelligence (multi-trait analysis); BRCA cis rs7089973 0.585 rs7907837 chr10:116610690 G/T cg23260525 chr10:116636907 FAM160B1 0.32 8.45 0.32 1.9e-16 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.47 0.38 8.7e-24 Cognitive ability; BRCA cis rs7917772 0.560 rs10786697 chr10:104378563 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.11 0.49 1.5e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs757278 0.608 rs4500028 chr7:117342315 T/A cg10524701 chr7:117356490 CTTNBP2 0.43 7.9 0.3 1.23e-14 Response to methotrexate in juvenile idiopathic arthritis; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg12564285 chr5:131593104 PDLIM4 0.38 9.5 0.35 4.17e-20 Acylcarnitine levels; BRCA cis rs9443189 0.570 rs775072 chr6:76377998 G/A cg01950844 chr6:76311363 SENP6 -0.84 -13.48 -0.47 1.32e-36 Prostate cancer; BRCA cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg05868516 chr6:26286170 HIST1H4H 0.51 11.33 0.41 3.05e-27 Educational attainment; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg25036284 chr2:26402008 FAM59B 0.95 16.07 0.54 4.82e-49 Gut microbiome composition (summer); BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.39e-15 Total body bone mineral density; BRCA cis rs11051970 0.879 rs2728680 chr12:32583512 T/C cg02745156 chr12:32552066 NA 0.27 8.89 0.33 6.35e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg03452623 chr4:187889614 NA -0.31 -10.06 -0.37 3.36e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs9527 0.615 rs7917295 chr10:104701187 A/G cg04362960 chr10:104952993 NT5C2 0.45 10.19 0.37 1.09e-22 Arsenic metabolism; BRCA cis rs2559856 1.000 rs10860771 chr12:102087242 A/G cg12924262 chr12:102091054 CHPT1 0.38 8.56 0.32 8.5e-17 Blood protein levels; BRCA cis rs7095944 0.584 rs4962692 chr10:126424823 G/A cg08799069 chr10:126477246 METTL10 -0.38 -8.85 -0.33 8.32e-18 Asthma; BRCA cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg00983440 chr10:79422392 NA -0.54 -10.21 -0.37 8.98e-23 Bone mineral density; BRCA trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg15556689 chr8:8085844 FLJ10661 -0.41 -10.85 -0.39 2.62e-25 Neuroticism; BRCA trans rs11098499 0.909 rs79026312 chr4:120440677 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.34 0.31 4.72e-16 Corneal astigmatism; BRCA cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.68 0.42 1.01e-28 Homoarginine levels; BRCA cis rs1050631 0.564 rs1785929 chr18:33725165 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.39 7.93 0.3 1.01e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs4363385 0.782 rs310105 chr1:153022253 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.51 -0.32 1.27e-16 Inflammatory skin disease; BRCA cis rs312273 0.967 rs312269 chr12:41249381 T/G cg17827154 chr12:41323612 CNTN1 -0.41 -9.88 -0.36 1.63e-21 Bipolar disorder; BRCA cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg12310025 chr6:25882481 NA -0.56 -13.43 -0.47 2.13e-36 Blood metabolite levels; BRCA cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.75 -0.45 2.44e-33 Bipolar disorder; BRCA trans rs9944715 1.000 rs718514 chr18:43856354 A/C cg01718231 chr17:29326311 RNF135 -0.43 -8.56 -0.32 8.57e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg16325326 chr1:53192061 ZYG11B 0.86 25.26 0.71 3.84e-98 Monocyte count; BRCA cis rs6912958 0.703 rs9359748 chr6:88095500 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.05 0.4 4.12e-26 Monocyte percentage of white cells; BRCA cis rs7851660 0.967 rs1443435 chr9:100617583 T/C cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.78e-17 Strep throat; BRCA cis rs2710642 0.927 rs1468748 chr2:63204611 C/T cg17519650 chr2:63277830 OTX1 0.37 8.3 0.31 6.24e-16 LDL cholesterol levels;LDL cholesterol; BRCA cis rs4074536 0.740 rs6659025 chr1:116301019 A/G cg21648376 chr1:116311395 CASQ2 -0.48 -8.54 -0.32 9.76e-17 QRS duration; BRCA cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.58 -12.15 -0.43 1.04e-30 Hip circumference adjusted for BMI; BRCA cis rs1568889 0.838 rs6484347 chr11:28040969 G/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.77 -19.92 -0.62 4.9e-69 Bipolar disorder; BRCA cis rs4766646 0.619 rs7397059 chr12:110310916 C/T cg01252219 chr12:110302105 GLTP 0.36 8.15 0.31 1.92e-15 Metabolite levels (MHPG); BRCA cis rs34779708 0.966 rs12762493 chr10:35471873 G/A cg03585969 chr10:35415529 CREM 0.45 9.44 0.35 7.02e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg23978390 chr7:1156363 C7orf50 0.4 9.11 0.34 1.08e-18 Longevity;Endometriosis; BRCA cis rs62103177 0.525 rs4799116 chr18:77736735 A/G cg02751453 chr18:77725136 HSBP1L1 0.37 9.06 0.34 1.54e-18 Opioid sensitivity; BRCA cis rs7246657 0.943 rs1382357 chr19:37977609 G/A cg18154014 chr19:37997991 ZNF793 0.49 9.68 0.36 9.12e-21 Coronary artery calcification; BRCA cis rs7572733 0.534 rs4850813 chr2:198775982 C/T cg00792783 chr2:198669748 PLCL1 -0.48 -10.32 -0.38 3.35e-23 Dermatomyositis; BRCA cis rs1712517 0.844 rs4918003 chr10:105044157 C/T cg05636881 chr10:105038444 INA 0.4 9.02 0.34 2.24e-18 Migraine; BRCA cis rs6545883 0.894 rs10177303 chr2:61594459 G/A cg15711740 chr2:61764176 XPO1 0.5 12.35 0.44 1.39e-31 Tuberculosis; BRCA cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg11833968 chr6:79620685 NA -0.44 -9.81 -0.36 2.92e-21 Intelligence (multi-trait analysis); BRCA cis rs11792861 0.816 rs2304779 chr9:111670513 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.45 -8.21 -0.31 1.23e-15 Menarche (age at onset); BRCA cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg11301795 chr4:187892539 NA -0.31 -10.26 -0.38 5.62e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs6598955 0.671 rs57386998 chr1:26569821 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs16976116 0.901 rs7172108 chr15:55501551 C/G cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg06060754 chr5:176797920 RGS14 0.59 11.18 0.4 1.31e-26 Hemoglobin concentration;Hematocrit; BRCA trans rs2197308 0.740 rs11182251 chr12:37919611 C/T cg06521331 chr12:34319734 NA 0.44 8.48 0.32 1.57e-16 Morning vs. evening chronotype; BRCA cis rs6542838 0.702 rs6419564 chr2:99534113 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -9.35 -0.35 1.51e-19 Fear of minor pain; BRCA cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg08999081 chr20:33150536 PIGU 0.36 9.31 0.35 2.01e-19 Coronary artery disease; BRCA cis rs11083475 0.686 rs73040728 chr19:39257601 C/G cg07403899 chr19:39283540 NA -0.24 -8.02 -0.3 5.02e-15 Heart rate; BRCA cis rs12973672 1.000 rs1051995 chr19:35770292 C/T cg12095397 chr19:35769544 USF2 0.38 8.38 0.31 3.28e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg25173405 chr17:45401733 C17orf57 0.54 11.18 0.4 1.3e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs1005277 0.522 rs1208681 chr10:38092975 C/T cg17830980 chr10:43048298 ZNF37B -0.43 -9.98 -0.37 6.54e-22 Extrinsic epigenetic age acceleration; BRCA trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg03929089 chr4:120376271 NA -0.66 -13.2 -0.46 2.35e-35 Height; BRCA cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg23029597 chr12:123009494 RSRC2 -0.48 -10.09 -0.37 2.62e-22 Body mass index; BRCA cis rs514406 0.760 rs475969 chr1:53292607 T/A cg08859206 chr1:53392774 SCP2 -0.56 -12.3 -0.44 2.27e-31 Monocyte count; BRCA cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg26647111 chr11:31128758 NA -0.43 -9.41 -0.35 8.91e-20 Red blood cell count; BRCA cis rs1029738 0.659 rs1608553 chr7:22896231 G/C cg22407942 chr7:22894828 SNORD93 -0.3 -8.45 -0.32 1.9e-16 Fibrinogen levels; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.23 -0.31 1.05e-15 Total body bone mineral density; BRCA cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg01884057 chr2:25150051 NA 0.32 8.52 0.32 1.19e-16 Body mass index in non-asthmatics; BRCA cis rs11190604 0.806 rs11190510 chr10:102157175 G/A cg07080220 chr10:102295463 HIF1AN 0.49 10.17 0.37 1.33e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs672059 0.967 rs514183 chr1:183163174 A/C ch.1.3577855R chr1:183094577 LAMC1 0.38 8.61 0.32 5.48e-17 Hypertriglyceridemia; BRCA cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -14.79 -0.51 8.4e-43 Personality dimensions; BRCA cis rs9811920 0.541 rs1016914 chr3:99640121 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.78 0.55 1.27e-52 Axial length; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg27170947 chr2:26402098 FAM59B -0.98 -17.28 -0.56 3.42e-55 Gut microbiome composition (summer); BRCA trans rs1005277 0.579 rs1780122 chr10:38529509 C/A cg17830980 chr10:43048298 ZNF37B -0.55 -13.32 -0.47 6.81e-36 Extrinsic epigenetic age acceleration; BRCA cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.5 0.44 3.3e-32 Bipolar disorder; BRCA cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg00677455 chr12:58241039 CTDSP2 0.39 8.99 0.34 2.79e-18 Multiple sclerosis; BRCA cis rs6460942 0.915 rs7803056 chr7:12306913 A/C cg10578991 chr7:12443926 VWDE -0.44 -8.08 -0.3 3.35e-15 Coronary artery disease; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg04025307 chr7:1156635 C7orf50 0.38 9.14 0.34 8.2e-19 Longevity;Endometriosis; BRCA cis rs9859260 0.710 rs41298097 chr3:195779155 C/T cg12923728 chr3:195709715 SDHAP1 0.38 7.92 0.3 1.09e-14 Mean corpuscular volume; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg24101359 chr6:42928495 GNMT 0.54 12.75 0.45 2.43e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs782590 0.967 rs1084522 chr2:55843294 A/G cg18811423 chr2:55921094 PNPT1 0.72 22.7 0.67 4.07e-84 Metabolic syndrome; BRCA cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.17 -0.31 1.66e-15 Aortic root size; BRCA cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg05868516 chr6:26286170 HIST1H4H 0.41 8.1 0.31 2.8e-15 Educational attainment; BRCA cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg02574844 chr11:5959923 NA -0.4 -8.5 -0.32 1.33e-16 DNA methylation (variation); BRCA cis rs1018836 0.923 rs4734269 chr8:91635474 G/C cg16814680 chr8:91681699 NA -0.51 -10.67 -0.39 1.45e-24 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs7613875 0.580 rs12634780 chr3:50043341 A/T cg21659725 chr3:3221576 CRBN -0.34 -8.03 -0.3 4.75e-15 Body mass index; BRCA cis rs1165668 0.785 rs2583223 chr12:104316841 G/A cg21863207 chr12:104234989 NT5DC3 0.39 8.02 0.3 5.08e-15 Coronary heart disease (SNP X SNP interaction); BRCA cis rs11711311 0.712 rs2271498 chr3:113334752 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.38 -8.3 -0.31 6.1e-16 IgG glycosylation; BRCA cis rs1949733 0.523 rs62287455 chr4:8544994 A/T cg11789530 chr4:8429930 ACOX3 -0.53 -12.19 -0.43 6.87e-31 Response to antineoplastic agents; BRCA cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.19 0.31 1.46e-15 Cognitive ability; BRCA cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg20573242 chr4:122745356 CCNA2 0.49 11.28 0.41 4.91e-27 Type 2 diabetes; BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg11814155 chr7:99998594 ZCWPW1 0.43 8.19 0.31 1.38e-15 Platelet count; BRCA cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.5e-77 Mean platelet volume; BRCA cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.95 0.3 8.6e-15 Depression; BRCA cis rs6785206 0.892 rs6793907 chr3:128391626 A/G cg16766828 chr3:128327626 NA 0.73 11.48 0.41 7.28e-28 Lymphocyte percentage of white cells; BRCA cis rs7582180 0.629 rs13010911 chr2:100953390 G/C cg14675211 chr2:100938903 LONRF2 0.51 11.53 0.41 4.71e-28 Intelligence (multi-trait analysis); BRCA cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg11645453 chr3:52864694 ITIH4 0.48 11.55 0.42 3.69e-28 Schizophrenia; BRCA cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg19077165 chr18:44547161 KATNAL2 -0.39 -8.25 -0.31 9.35e-16 Educational attainment; BRCA cis rs9309711 0.736 rs13412581 chr2:3497187 G/A cg10845886 chr2:3471009 TTC15 -0.66 -12.92 -0.45 4.53e-34 Neurofibrillary tangles; BRCA trans rs6951245 1.000 rs1997243 chr7:1083777 A/G cg13565492 chr6:43139072 SRF -0.79 -10.98 -0.4 8.18e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg04455712 chr21:45112962 RRP1B 0.41 11.34 0.41 2.8e-27 Mean corpuscular volume; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg04267008 chr7:1944627 MAD1L1 -0.61 -13.55 -0.47 5.83e-37 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg09184832 chr6:79620586 NA -0.42 -8.19 -0.31 1.39e-15 Intelligence (multi-trait analysis); BRCA cis rs2985684 0.779 rs12160 chr14:50091932 T/A cg04989706 chr14:50066350 PPIL5 -0.48 -9.17 -0.34 6.6e-19 Carotid intima media thickness; BRCA cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg18016565 chr1:150552671 MCL1 -0.42 -9.66 -0.36 1.06e-20 Tonsillectomy; BRCA trans rs6479891 1.000 rs9414800 chr10:65131282 T/A cg14819942 chr15:35414228 NA 0.35 8.6 0.32 6.08e-17 Arthritis (juvenile idiopathic); BRCA cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.84 12.63 0.45 7.99e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg14689365 chr7:158441557 NCAPG2 -0.42 -8.59 -0.32 6.72e-17 Height; BRCA cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg03213289 chr20:61660250 NA 0.61 16.24 0.54 6.55e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs12926788 0.640 rs73551577 chr16:24845143 G/A cg06028605 chr16:24865363 SLC5A11 0.43 9.75 0.36 4.94e-21 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs2011503 1.000 rs76095338 chr19:19633908 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg12560992 chr17:57184187 TRIM37 0.39 8.77 0.33 1.57e-17 Primary tooth development (time to first tooth eruption); BRCA cis rs1949733 0.523 rs4619877 chr4:8543235 G/A cg11789530 chr4:8429930 ACOX3 -0.55 -12.61 -0.45 1.05e-32 Response to antineoplastic agents; BRCA cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.63 12.96 0.46 2.79e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs7904368 0.806 rs7899853 chr10:16857603 A/T cg14835575 chr10:16859367 RSU1 0.64 13.91 0.48 1.25e-38 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.35 0.61 5.38e-66 Cognitive function; BRCA cis rs7493 1.000 rs7786401 chr7:95034001 G/T cg17330251 chr7:94953956 PON1 -0.41 -8.7 -0.33 2.84e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg02734326 chr4:10020555 SLC2A9 0.38 8.22 0.31 1.17e-15 Bone mineral density; BRCA cis rs1448094 0.621 rs10863091 chr12:86282240 T/C cg19622623 chr12:86230825 RASSF9 -0.29 -8.26 -0.31 8.66e-16 Major depressive disorder; BRCA cis rs11764590 0.694 rs11762413 chr7:2090387 C/G cg23422044 chr7:1970798 MAD1L1 -0.46 -9.74 -0.36 5.34e-21 Neuroticism; BRCA cis rs1865721 1.000 rs7236756 chr18:73175689 T/C cg26385618 chr18:73139727 C18orf62 -0.4 -9.05 -0.34 1.67e-18 Intelligence; BRCA cis rs2016266 0.819 rs7398228 chr12:53660285 T/C cg26875137 chr12:53738046 NA 0.38 9.73 0.36 5.87e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg05872129 chr22:39784769 NA -0.51 -11.12 -0.4 2.23e-26 Intelligence (multi-trait analysis); BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg24642844 chr7:1081250 C7orf50 -0.89 -16.22 -0.54 8.17e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.58 0.55 1.29e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.29 0.41 4.47e-27 Bipolar disorder; BRCA cis rs1401999 0.966 rs2139560 chr3:183653869 A/G cg01324343 chr3:183735012 ABCC5 0.85 21.76 0.65 5.82e-79 Anterior chamber depth; BRCA cis rs701145 0.585 rs1534386 chr3:153819035 C/G cg12800244 chr3:153838788 SGEF 0.63 7.87 0.3 1.47e-14 Coronary artery disease; BRCA cis rs56399783 0.614 rs73047368 chr7:2766396 G/T cg19731401 chr7:2775893 GNA12 0.54 8.53 0.32 1.06e-16 Childhood ear infection; BRCA cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.02 0.3 5.16e-15 Tonsillectomy; BRCA cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg16339924 chr4:17578868 LAP3 0.54 13.31 0.47 7.37e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg03354898 chr7:1950403 MAD1L1 -0.48 -10.07 -0.37 2.99e-22 Bipolar disorder and schizophrenia; BRCA cis rs4908768 0.501 rs1922983 chr1:8531326 A/G cg20416874 chr1:8611966 RERE -0.28 -8.06 -0.3 3.84e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs7927771 0.832 rs10838699 chr11:47386073 T/C cg20307385 chr11:47447363 PSMC3 0.37 8.01 0.3 5.56e-15 Subjective well-being; BRCA cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg20476274 chr7:133979776 SLC35B4 0.6 16.15 0.54 1.82e-49 Mean platelet volume; BRCA cis rs4662945 0.603 rs1453147 chr2:130271510 A/C cg05903289 chr2:130345205 NA -0.33 -8.06 -0.3 3.75e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs34779708 0.733 rs7083266 chr10:35541632 C/A cg03585969 chr10:35415529 CREM 0.45 9.16 0.34 6.91e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg12756686 chr19:29218302 NA 0.46 8.07 0.3 3.39e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg14820908 chr5:178986412 RUFY1 0.44 11.2 0.41 1.01e-26 Lung cancer; BRCA cis rs6121246 0.609 rs6060955 chr20:30385071 A/G cg13852791 chr20:30311386 BCL2L1 0.89 20.17 0.62 2.15e-70 Mean corpuscular hemoglobin; BRCA cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.3 -0.31 6.02e-16 Aortic root size; BRCA cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg03929089 chr4:120376271 NA -0.69 -14.66 -0.5 3.76e-42 Coronary artery disease; BRCA cis rs11105298 0.891 rs4842654 chr12:89834428 T/A cg00757033 chr12:89920650 WDR51B 0.54 10.82 0.39 3.61e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6138458 0.626 rs6050261 chr20:25014206 C/T cg26195577 chr20:24973756 C20orf3 0.64 15.67 0.53 4.41e-47 Blood protein levels; BRCA cis rs17604090 0.529 rs10239226 chr7:29716312 C/G cg19413766 chr7:29689036 LOC646762 -0.56 -9.01 -0.34 2.35e-18 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs4728302 0.838 rs10224828 chr7:133591071 G/A cg07491979 chr7:133331646 EXOC4 0.36 7.81 0.3 2.32e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg22906224 chr7:99728672 NA 0.44 8.4 0.32 2.92e-16 Coronary artery disease; BRCA cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg11657440 chr19:46296263 DMWD -0.45 -10.25 -0.38 6.31e-23 Coronary artery disease; BRCA cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg27286337 chr10:134555280 INPP5A 0.8 13.17 0.46 3.32e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6882046 0.513 rs601942 chr5:88031820 T/C cg22951263 chr5:87985283 NA -0.38 -10.65 -0.39 1.72e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.73 -15.0 -0.51 8.14e-44 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs853679 0.517 rs9357063 chr6:28060005 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.25 -0.31 9.02e-16 Depression; BRCA cis rs12310956 0.532 rs1352209 chr12:33983408 G/A cg06521331 chr12:34319734 NA -0.56 -10.84 -0.39 2.95e-25 Morning vs. evening chronotype; BRCA cis rs868036 0.957 rs9920662 chr15:68104297 G/A cg05925327 chr15:68127851 NA -0.31 -7.9 -0.3 1.23e-14 Restless legs syndrome; BRCA cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg05340658 chr4:99064831 C4orf37 0.59 14.46 0.5 3.43e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg06028605 chr16:24865363 SLC5A11 0.43 9.65 0.36 1.17e-20 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg07636037 chr3:49044803 WDR6 0.98 29.45 0.76 4.2e-121 Parkinson's disease; BRCA cis rs11190604 0.767 rs7916904 chr10:102186778 C/G cg07080220 chr10:102295463 HIF1AN 0.47 10.63 0.39 2.03e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg07061783 chr6:25882402 NA -0.45 -9.04 -0.34 1.8e-18 Urate levels; BRCA cis rs425277 1.000 rs262676 chr1:2078482 T/A cg00981070 chr1:2046702 PRKCZ 0.31 8.25 0.31 9.06e-16 Height; BRCA cis rs1829883 0.729 rs2682142 chr5:98899578 T/C cg08333243 chr5:99726346 NA -0.34 -8.19 -0.31 1.42e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs16854884 0.683 rs6766544 chr3:143736659 G/T cg06585982 chr3:143692056 C3orf58 0.43 8.99 0.33 2.87e-18 Economic and political preferences (feminism/equality); BRCA cis rs1506636 1.000 rs2429619 chr7:123425599 C/G cg03229431 chr7:123269106 ASB15 0.61 13.53 0.47 7.36e-37 Plateletcrit;Platelet count; BRCA trans rs11098499 0.955 rs1511018 chr4:120161580 G/T cg25214090 chr10:38739885 LOC399744 0.5 11.02 0.4 5.79e-26 Corneal astigmatism; BRCA cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.4 -0.32 2.82e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg14530993 chr4:882597 GAK 0.6 9.75 0.36 4.99e-21 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg20476274 chr7:133979776 SLC35B4 0.62 18.04 0.58 4.19e-59 Mean platelet volume; BRCA cis rs7927592 0.913 rs7118897 chr11:68360680 G/A cg20283391 chr11:68216788 NA -0.43 -8.56 -0.32 8.2e-17 Total body bone mineral density; BRCA cis rs8180040 1.000 rs1024037 chr3:47318449 C/A cg16586182 chr3:47516702 SCAP 0.63 14.55 0.5 1.18e-41 Colorectal cancer; BRCA cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg23711669 chr6:146136114 FBXO30 -0.79 -18.4 -0.59 5.66e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs60843830 0.661 rs62116682 chr2:104618 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.49 9.27 0.34 2.83e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg02551604 chr5:131831745 NA -0.39 -14.1 -0.49 1.7e-39 Asthma (sex interaction); BRCA cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg16482183 chr6:26056742 HIST1H1C 0.52 11.13 0.4 1.99e-26 Height; BRCA cis rs8114671 0.562 rs6058120 chr20:33402829 A/G cg24642439 chr20:33292090 TP53INP2 0.45 9.86 0.36 1.96e-21 Height; BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.74 16.0 0.53 1.1e-48 Lymphocyte counts; BRCA trans rs208520 0.955 rs28684412 chr6:66979430 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.4 0.49 6.56e-41 Exhaled nitric oxide output; BRCA cis rs73001065 0.818 rs12610191 chr19:19721976 C/T cg03709012 chr19:19516395 GATAD2A 0.76 9.18 0.34 5.84e-19 LDL cholesterol; BRCA cis rs2066819 1.000 rs80317430 chr12:56727705 G/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs1403694 0.695 rs3774292 chr3:186433574 A/T cg12454167 chr3:186435060 KNG1 0.29 7.92 0.3 1.04e-14 Blood protein levels; BRCA cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg26384229 chr12:38710491 ALG10B -0.62 -16.08 -0.54 4.35e-49 Heart rate; BRCA cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg18132916 chr6:79620363 NA -0.4 -8.15 -0.31 1.87e-15 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.735 rs396000 chr6:109519611 A/G cg01475377 chr6:109611718 NA 0.47 12.04 0.43 2.98e-30 Reticulocyte fraction of red cells; BRCA cis rs4660306 1.000 rs2077808 chr1:45988115 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.96 -0.3 8.12e-15 Homocysteine levels; BRCA cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg12311346 chr5:56204834 C5orf35 -0.94 -18.23 -0.58 4.4e-60 Initial pursuit acceleration; BRCA cis rs921968 0.643 rs832799 chr2:219490111 C/A cg02176678 chr2:219576539 TTLL4 0.43 11.56 0.42 3.34e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs2386661 0.522 rs11258044 chr10:5644392 C/T cg17085576 chr10:5658249 NA -0.32 -8.18 -0.31 1.58e-15 Breast cancer; BRCA cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg18876405 chr7:65276391 NA 0.71 18.63 0.59 3.17e-62 Calcium levels; BRCA cis rs1865760 0.964 rs1324084 chr6:25915134 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.41 0.38 1.49e-23 Height; BRCA cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg18876405 chr7:65276391 NA 0.7 18.38 0.59 7.02e-61 Aortic root size; BRCA cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.87 0.33 7.22e-18 Motion sickness; BRCA cis rs6500395 0.962 rs9937623 chr16:48571590 A/T cg04672837 chr16:48644449 N4BP1 -0.43 -10.12 -0.37 1.93e-22 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.61 12.97 0.46 2.62e-34 Personality dimensions; BRCA cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg13010199 chr12:38710504 ALG10B 0.43 9.03 0.34 2e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs9658691 0.607 rs12416581 chr10:90780440 C/T cg03111039 chr10:90751583 FAS;ACTA2 -0.52 -8.02 -0.3 4.91e-15 Mosquito bite size; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg04709771 chr16:646395 RAB40C 0.44 10.84 0.39 2.93e-25 Height; BRCA cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg13319975 chr6:146136371 FBXO30 0.42 9.7 0.36 7.66e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs709400 0.627 rs55859054 chr14:103953666 T/A cg26031613 chr14:104095156 KLC1 0.74 15.96 0.53 1.67e-48 Body mass index; BRCA cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg18351406 chr4:77819688 ANKRD56 0.54 11.96 0.43 6.86e-30 Emphysema distribution in smoking; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg23978390 chr7:1156363 C7orf50 0.48 11.33 0.41 2.99e-27 Longevity;Endometriosis; BRCA cis rs35306767 0.623 rs34034003 chr10:1143435 G/A cg20503657 chr10:835505 NA 0.68 10.88 0.4 2.13e-25 Eosinophil percentage of granulocytes; BRCA cis rs2066819 1.000 rs118130855 chr12:56677979 T/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg00321850 chr1:175162397 KIAA0040 0.44 12.4 0.44 9.02e-32 Alcohol dependence; BRCA cis rs6484504 0.625 rs6484501 chr11:31373100 G/T cg06552810 chr11:31128660 NA 0.4 8.73 0.33 2.16e-17 Red blood cell count; BRCA cis rs9818758 0.556 rs9872660 chr3:49378832 G/T cg00383909 chr3:49044727 WDR6 0.52 10.13 0.37 1.85e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.26 0.59 2.84e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.4e-77 Mean platelet volume; BRCA cis rs7617773 0.817 rs13068265 chr3:48301614 A/C cg11946769 chr3:48343235 NME6 0.67 13.98 0.48 5.92e-39 Coronary artery disease; BRCA trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg20587970 chr11:113659929 NA 1.02 14.49 0.5 2.42e-41 Hip circumference adjusted for BMI; BRCA cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg10495392 chr1:46806563 NSUN4 0.47 8.73 0.33 2.19e-17 Menopause (age at onset); BRCA cis rs11191270 0.554 rs11191275 chr10:104142800 C/T cg12477931 chr10:104193363 CUEDC2 -0.5 -7.81 -0.3 2.35e-14 Intelligence (multi-trait analysis); BRCA cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg27478167 chr7:817139 HEATR2 0.45 9.01 0.34 2.31e-18 Cerebrospinal P-tau181p levels; BRCA cis rs372883 0.648 rs15092 chr21:30718201 G/A cg24692254 chr21:30365293 RNF160 -0.47 -10.62 -0.39 2.34e-24 Pancreatic cancer; BRCA cis rs1707322 0.752 rs3811436 chr1:46125880 T/C cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg00677455 chr12:58241039 CTDSP2 0.68 15.19 0.52 9.85e-45 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18765753 chr7:1198926 ZFAND2A -0.36 -8.83 -0.33 9.73e-18 Longevity;Endometriosis; BRCA cis rs754466 0.606 rs11002309 chr10:79594931 C/T cg17075019 chr10:79541650 NA -0.81 -20.56 -0.63 1.81e-72 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs250677 0.687 rs250664 chr5:148453823 C/T cg12140854 chr5:148520817 ABLIM3 -0.42 -9.02 -0.34 2.18e-18 Breast cancer; BRCA cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg22467129 chr15:76604101 ETFA 0.39 8.6 0.32 6.39e-17 Blood metabolite levels; BRCA trans rs208520 0.690 rs2208442 chr6:66867004 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.46 -0.63 5.77e-72 Exhaled nitric oxide output; BRCA cis rs6700896 0.931 rs4655582 chr1:66153363 C/G cg04111102 chr1:66153794 NA 0.42 9.97 0.37 7.42e-22 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7264396 0.580 rs2064511 chr20:34448810 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.64 11.93 0.43 9.57e-30 Total cholesterol levels; BRCA cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg04586622 chr2:25135609 ADCY3 0.46 11.76 0.42 4.91e-29 Body mass index; BRCA cis rs7617773 0.780 rs4511915 chr3:48343858 G/A cg11946769 chr3:48343235 NME6 0.69 13.87 0.48 2.01e-38 Coronary artery disease; BRCA cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg08610935 chr16:1836813 NUBP2 -0.43 -11.19 -0.4 1.12e-26 Insulin-like growth factors; BRCA cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg25358565 chr5:93447407 FAM172A -1.16 -18.35 -0.59 9.85e-61 Diabetic retinopathy; BRCA trans rs61931739 0.517 rs12367881 chr12:34175508 T/C cg26384229 chr12:38710491 ALG10B 0.69 14.65 0.5 4.12e-42 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8170 0.603 rs971693 chr19:17422649 G/C cg02455703 chr19:17412272 ABHD8 -0.34 -7.84 -0.3 1.87e-14 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs4713675 0.584 rs9394163 chr6:33682414 A/G cg14003231 chr6:33640908 ITPR3 0.33 8.41 0.32 2.6e-16 Plateletcrit; BRCA cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.54 -0.44 2.15e-32 Developmental language disorder (linguistic errors); BRCA cis rs11098499 0.863 rs7695620 chr4:120452776 G/A cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs1451375 1.000 rs921451 chr7:50623285 A/G cg18232548 chr7:50535776 DDC 0.43 10.12 0.37 1.99e-22 Malaria; BRCA cis rs2425143 1.000 rs17093026 chr20:34318911 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.57 8.38 0.31 3.36e-16 Blood protein levels; BRCA cis rs4363385 0.747 rs3964619 chr1:152972811 A/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.22 -0.31 1.13e-15 Inflammatory skin disease; BRCA cis rs9287719 0.967 rs10203664 chr2:10752377 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg11663144 chr21:46675770 NA -0.62 -14.66 -0.5 3.53e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1322639 0.806 rs1322640 chr6:169586887 T/C cg03254818 chr6:169586852 NA -0.41 -8.67 -0.32 3.55e-17 Pulse pressure; BRCA cis rs2288073 1.000 rs2288073 chr2:24413298 C/T cg06627628 chr2:24431161 ITSN2 0.6 11.51 0.41 5.31e-28 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg26913058 chr16:419975 MRPL28 -0.37 -8.78 -0.33 1.52e-17 Bone mineral density (spine);Bone mineral density; BRCA cis rs1448094 0.512 rs11117057 chr12:86248546 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.83e-19 Major depressive disorder; BRCA cis rs2370759 1.000 rs76467481 chr10:32610740 T/G cg01819863 chr10:32635814 EPC1 1.14 19.89 0.62 7.38e-69 Sexual dysfunction (female); BRCA cis rs4727027 0.704 rs12704071 chr7:148904795 C/T cg23583168 chr7:148888333 NA -0.85 -22.35 -0.66 3.26e-82 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs330048 0.545 rs11249913 chr8:9143521 G/T cg15556689 chr8:8085844 FLJ10661 -0.41 -10.68 -0.39 1.3e-24 Systemic lupus erythematosus; BRCA cis rs7086627 0.515 rs7907969 chr10:82153005 T/A cg00277334 chr10:82204260 NA -0.48 -10.26 -0.38 5.96e-23 Post bronchodilator FEV1; BRCA cis rs858239 0.699 rs858260 chr7:23212934 G/T cg23682824 chr7:23144976 KLHL7 0.35 9.08 0.34 1.3e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs7178424 0.967 rs17271403 chr15:62375389 C/T cg00456672 chr15:62358751 C2CD4A -0.36 -8.41 -0.32 2.77e-16 Height; BRCA cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg10802521 chr3:52805072 NEK4 -0.33 -8.49 -0.32 1.45e-16 Bipolar disorder; BRCA cis rs853679 0.517 rs9380049 chr6:28048535 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.15e-15 Depression; BRCA cis rs7520050 0.966 rs12049588 chr1:46472422 G/A cg24296786 chr1:45957014 TESK2 0.44 9.84 0.36 2.33e-21 Red blood cell count;Reticulocyte count; BRCA cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg05535760 chr7:792225 HEATR2 0.73 13.46 0.47 1.52e-36 Cerebrospinal P-tau181p levels; BRCA cis rs637571 0.726 rs526631 chr11:65681965 T/G cg02427764 chr11:65769310 BANF1;EIF1AD -0.46 -9.44 -0.35 6.84e-20 Eosinophil percentage of white cells; BRCA cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg26116260 chr4:7069785 GRPEL1 0.93 27.24 0.73 4.83e-109 Monocyte percentage of white cells; BRCA trans rs61931739 0.513 rs10772116 chr12:33897795 G/C cg26384229 chr12:38710491 ALG10B 0.46 10.77 0.39 5.91e-25 Morning vs. evening chronotype; BRCA cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg11266682 chr4:10021025 SLC2A9 0.48 12.8 0.45 1.51e-33 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.04 0.4 4.78e-26 Rheumatoid arthritis; BRCA cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg00012203 chr2:219082015 ARPC2 0.48 9.22 0.34 4.08e-19 Colorectal cancer; BRCA cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05039488 chr6:79577232 IRAK1BP1 0.37 8.27 0.31 7.98e-16 Endometrial cancer; BRCA cis rs2832077 0.943 rs2832094 chr21:30165910 G/A cg08807101 chr21:30365312 RNF160 -0.45 -7.89 -0.3 1.35e-14 Cognitive test performance; BRCA cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs586533 0.881 rs638740 chr11:99504483 A/T cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.31 2.78e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg25809561 chr17:30822961 MYO1D 0.4 9.52 0.35 3.4e-20 Schizophrenia; BRCA trans rs877282 0.947 rs7475589 chr10:767479 C/G cg22713356 chr15:30763199 NA 1.35 26.98 0.73 1.41e-107 Uric acid levels; BRCA cis rs7640424 0.620 rs71321252 chr3:107813107 A/C cg09227934 chr3:107805635 CD47 -0.43 -8.2 -0.31 1.32e-15 Body mass index; BRCA cis rs9469890 0.604 rs11758420 chr6:34503279 A/C cg17674042 chr6:34482479 PACSIN1 -0.33 -8.56 -0.32 8.1e-17 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs9486719 1.000 rs12214469 chr6:97019471 G/T cg06623918 chr6:96969491 KIAA0776 -0.77 -13.77 -0.48 5.7800000000000005e-38 Migraine;Coronary artery disease; BRCA cis rs8038465 0.622 rs7182124 chr15:73915254 C/T cg15420318 chr15:73925796 NPTN 0.48 10.33 0.38 3.08e-23 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg25110423 chr6:41068646 NFYA;LOC221442 0.39 9.36 0.35 1.35e-19 Alzheimer's disease (late onset); BRCA cis rs6426558 0.537 rs6662583 chr1:227383889 A/G cg10327440 chr1:227177885 CDC42BPA -0.48 -9.8 -0.36 3.26e-21 Neutrophil percentage of white cells; BRCA cis rs6973256 0.568 rs7783019 chr7:133347347 A/G cg07491979 chr7:133331646 EXOC4 -0.35 -8.1 -0.31 2.73e-15 Intelligence (multi-trait analysis); BRCA cis rs11971779 0.938 rs28477480 chr7:139036058 C/T cg07862535 chr7:139043722 LUC7L2 -0.4 -9.81 -0.36 2.85e-21 Diisocyanate-induced asthma; BRCA cis rs11098499 0.644 rs10050092 chr4:120532085 T/C cg09307838 chr4:120376055 NA 0.59 12.23 0.44 4.56e-31 Corneal astigmatism; BRCA cis rs6066835 1.000 rs6066828 chr20:47344233 C/T cg18078177 chr20:47281410 PREX1 0.69 8.65 0.32 4.17e-17 Multiple myeloma; BRCA trans rs11098499 0.865 rs11098513 chr4:120316075 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.29 0.31 6.82e-16 Corneal astigmatism; BRCA cis rs870825 0.549 rs7699919 chr4:185648610 A/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg06552810 chr11:31128660 NA 0.39 8.58 0.32 7.02e-17 Red blood cell count; BRCA cis rs6430585 0.583 rs4988201 chr2:136618507 A/G cg07169764 chr2:136633963 MCM6 1.28 28.78 0.75 1.99e-117 Corneal structure; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg03923535 chr7:1197113 ZFAND2A 0.4 7.83 0.3 1.97e-14 Longevity;Endometriosis; BRCA trans rs11098499 0.691 rs10028773 chr4:120265259 C/G cg25214090 chr10:38739885 LOC399744 -0.4 -9.48 -0.35 5.09e-20 Corneal astigmatism; BRCA cis rs698833 0.758 rs7586188 chr2:44544955 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.5 0.38 6.73e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.17e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4499344 0.768 rs10411319 chr19:33102805 C/A cg22980127 chr19:33182716 NUDT19 -0.37 -7.85 -0.3 1.8e-14 Mean platelet volume; BRCA cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg21775979 chr11:780331 NA 0.36 7.8 0.3 2.45e-14 Breast cancer; BRCA cis rs1997103 0.906 rs6593232 chr7:55402916 C/T cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg03146154 chr1:46216737 IPP 0.49 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9527 0.590 rs12415388 chr10:104796345 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.02 0.37 4.77e-22 Arsenic metabolism; BRCA cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.545 rs316328 chr7:65608838 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.45 -9.21 -0.34 4.54e-19 Aortic root size; BRCA cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg17691542 chr6:26056736 HIST1H1C 0.54 11.58 0.42 2.67e-28 Height; BRCA trans rs2197308 0.765 rs12824529 chr12:37931656 T/C cg06521331 chr12:34319734 NA -0.54 -9.58 -0.35 2.16e-20 Morning vs. evening chronotype; BRCA cis rs600231 0.708 rs661403 chr11:65242478 A/G cg01292856 chr11:65242576 NA 0.33 8.26 0.31 8.51e-16 Bone mineral density; BRCA cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2304069 0.954 rs4705409 chr5:149414899 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.77 16.11 0.54 2.93e-49 HIV-1 control; BRCA cis rs6429082 0.608 rs903348 chr1:235571343 C/T cg26050004 chr1:235667680 B3GALNT2 -0.53 -12.09 -0.43 1.89e-30 Adiposity; BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg04267008 chr7:1944627 MAD1L1 -0.64 -13.56 -0.47 5.52e-37 Bipolar disorder and schizophrenia; BRCA cis rs1568889 1.000 rs12803655 chr11:28060785 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.71 0.5 2.14e-42 Bipolar disorder; BRCA cis rs9790314 0.521 rs1450523 chr3:161077270 G/A cg04691961 chr3:161091175 C3orf57 -0.46 -10.84 -0.39 2.87e-25 Morning vs. evening chronotype; BRCA cis rs6570726 0.846 rs446031 chr6:145885592 C/T cg23711669 chr6:146136114 FBXO30 0.71 17.19 0.56 1.05e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs7551222 0.749 rs4951409 chr1:204560990 A/T cg20240347 chr1:204465584 NA -0.28 -8.73 -0.33 2.23e-17 Schizophrenia; BRCA cis rs597539 0.652 rs478647 chr11:68700424 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 17.96 0.58 1.11e-58 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg18357645 chr12:58087776 OS9 0.44 12.46 0.44 4.7e-32 Celiac disease or Rheumatoid arthritis; BRCA cis rs965469 0.708 rs80050989 chr20:3297881 A/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.73 -0.33 2.23e-17 IFN-related cytopenia; BRCA cis rs754466 0.580 rs17516020 chr10:79538734 C/T cg17075019 chr10:79541650 NA -0.74 -14.89 -0.51 2.8e-43 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs7824557 0.767 rs4559208 chr8:11153925 C/G cg08975724 chr8:8085496 FLJ10661 0.41 7.9 0.3 1.23e-14 Retinal vascular caliber; BRCA trans rs61931739 0.517 rs12815556 chr12:34319670 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.23 0.49 4.21e-40 Morning vs. evening chronotype; BRCA cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg10578991 chr7:12443926 VWDE -0.55 -7.9 -0.3 1.2e-14 Coronary artery disease; BRCA trans rs11098499 0.909 rs79704848 chr4:120309351 T/A cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs701145 0.585 rs1470664 chr3:153865193 C/T cg17054900 chr3:154042577 DHX36 0.43 8.07 0.3 3.55e-15 Coronary artery disease; BRCA cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg24562669 chr7:97807699 LMTK2 0.45 11.74 0.42 5.89e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs11958404 0.719 rs72818153 chr5:157487035 T/C cg05962755 chr5:157440814 NA 0.56 9.36 0.35 1.31e-19 IgG glycosylation; BRCA cis rs7582180 0.629 rs11694642 chr2:100957813 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.54 0.42 3.94e-28 Intelligence (multi-trait analysis); BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg02592271 chr2:27665507 KRTCAP3 -0.31 -7.84 -0.3 1.83e-14 Total body bone mineral density; BRCA cis rs7582180 0.739 rs10195793 chr2:100925803 A/G cg14675211 chr2:100938903 LONRF2 0.48 11.13 0.4 2.07e-26 Intelligence (multi-trait analysis); BRCA cis rs13108904 0.935 rs13148614 chr4:1248357 G/C cg05665937 chr4:1216051 CTBP1 0.39 8.21 0.31 1.27e-15 Obesity-related traits; BRCA cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg13319975 chr6:146136371 FBXO30 0.41 9.44 0.35 7.04e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.17 0.62 2.23e-70 Chronic sinus infection; BRCA cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg26597838 chr10:835615 NA 1.32 22.11 0.66 7.25e-81 Eosinophil percentage of granulocytes; BRCA cis rs7944584 0.588 rs2697923 chr11:47363215 G/T cg20307385 chr11:47447363 PSMC3 -0.51 -11.58 -0.42 2.83e-28 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9527 0.590 rs10883843 chr10:104947493 C/G cg04362960 chr10:104952993 NT5C2 0.43 9.66 0.36 1.11e-20 Arsenic metabolism; BRCA cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg16339924 chr4:17578868 LAP3 -0.59 -14.11 -0.49 1.54e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs6952808 0.595 rs2398705 chr7:2164995 G/A cg04565464 chr8:145669602 NFKBIL2 0.42 9.47 0.35 5.25e-20 Bipolar disorder and schizophrenia; BRCA cis rs6545883 0.825 rs4672426 chr2:61457148 G/A cg15711740 chr2:61764176 XPO1 0.51 13.06 0.46 1.06e-34 Tuberculosis; BRCA cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg00684032 chr4:1343700 KIAA1530 0.34 8.49 0.32 1.47e-16 Obesity-related traits; BRCA cis rs6910061 0.913 rs35199324 chr6:11112863 C/T cg27233058 chr6:11094804 LOC221710 0.53 9.43 0.35 7.64e-20 Diabetic kidney disease; BRCA cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.2 0.6 3.34e-65 Smoking behavior; BRCA cis rs11763147 1 rs11763147 chr7:65326821 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.44 -9.88 -0.36 1.64e-21 Corneal structure; BRCA trans rs7618501 0.521 rs2883059 chr3:49902160 C/T cg21659725 chr3:3221576 CRBN -0.38 -9.18 -0.34 5.82e-19 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.768 rs1766814 chr6:109526696 G/A cg21918786 chr6:109611834 NA -0.33 -8.96 -0.33 3.5e-18 Reticulocyte fraction of red cells; BRCA cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg16006841 chr5:176797999 RGS14 0.59 11.76 0.42 4.93e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs2204008 0.580 rs36118148 chr12:38411812 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.8 -0.36 3.32e-21 Bladder cancer; BRCA cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.62 13.88 0.48 1.79e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9527 0.590 rs34104646 chr10:104896078 T/A cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs10876993 0.784 rs7314152 chr12:58017701 T/G cg18357645 chr12:58087776 OS9 -0.41 -10.96 -0.4 9.6e-26 Celiac disease or Rheumatoid arthritis; BRCA cis rs3806843 0.676 rs778594 chr5:140027304 T/C cg16179182 chr5:140090404 VTRNA1-1 0.47 10.73 0.39 7.92e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.79 11.11 0.4 2.5e-26 Initial pursuit acceleration; BRCA cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg17971929 chr21:40555470 PSMG1 -0.62 -13.63 -0.47 2.5e-37 Cognitive function; BRCA cis rs2243480 1.000 rs34560516 chr7:65404092 A/T cg18252515 chr7:66147081 NA -0.9 -12.89 -0.45 6.08e-34 Diabetic kidney disease; BRCA cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg15017067 chr4:17643749 FAM184B 0.26 8.04 0.3 4.24e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3857067 0.806 rs72665627 chr4:95111824 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs6942756 0.747 rs692697 chr7:129112576 C/T cg02491457 chr7:128862824 NA 0.52 10.68 0.39 1.3e-24 White matter hyperintensity burden; BRCA cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 2.02e-19 Schizophrenia; BRCA cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -9.76 -0.36 4.37e-21 Bipolar disorder; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.52 8.35 0.31 4.13e-16 Renal function-related traits (BUN); BRCA cis rs250677 0.958 rs17109282 chr5:148416677 A/G cg12140854 chr5:148520817 ABLIM3 0.41 8.8 0.33 1.22e-17 Breast cancer; BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg25062951 chr7:817576 HEATR2 -0.38 -7.82 -0.3 2.19e-14 Cerebrospinal P-tau181p levels; BRCA trans rs3733585 0.699 rs11724510 chr4:9958583 C/T cg26043149 chr18:55253948 FECH -0.37 -8.12 -0.31 2.34e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11690935 0.879 rs908671 chr2:172690265 C/G cg13550731 chr2:172543902 DYNC1I2 -0.89 -27.51 -0.74 1.68e-110 Schizophrenia; BRCA cis rs2011503 1.000 rs111406321 chr19:19637437 G/A cg11584989 chr19:19387371 SF4 0.64 13.49 0.47 1.14e-36 Bipolar disorder; BRCA cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg12193833 chr17:30244370 NA -0.62 -9.85 -0.36 2e-21 Hip circumference adjusted for BMI; BRCA trans rs10411161 0.702 rs7251689 chr19:52389117 A/T cg22319618 chr22:45562946 NUP50 -0.42 -8.02 -0.3 4.89e-15 Breast cancer; BRCA cis rs11758351 0.660 rs77337633 chr6:26233610 T/C cg01420254 chr6:26195488 NA 0.55 8.52 0.32 1.1e-16 Gout;Renal underexcretion gout; BRCA cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.77e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg14835575 chr10:16859367 RSU1 0.65 14.32 0.49 1.58e-40 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs1451375 0.729 rs6593017 chr7:50644812 G/A cg18232548 chr7:50535776 DDC 0.39 9.19 0.34 5.5e-19 Malaria; BRCA cis rs11605275 1.000 rs16937347 chr11:20026717 A/G cg14835545 chr11:20032148 NAV2 -0.54 -9.58 -0.35 2.13e-20 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -12.23 -0.44 4.57e-31 Personality dimensions; BRCA cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 9.86 0.36 2e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg10523679 chr1:76189770 ACADM 0.77 15.5 0.52 3.17e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs752010 0.967 rs10890153 chr1:42102060 C/A cg06885757 chr1:42089581 HIVEP3 0.25 8.88 0.33 6.96e-18 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs12950390 0.814 rs11659069 chr17:45834275 G/T cg03474202 chr17:45855739 NA -0.46 -12.39 -0.44 9.18e-32 IgG glycosylation; BRCA cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg27129171 chr3:47204927 SETD2 0.77 19.97 0.62 2.64e-69 Colorectal cancer; BRCA cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.26 7.81 0.3 2.28e-14 Parkinson's disease; BRCA cis rs4363385 0.747 rs946097 chr1:152974732 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.07 -0.34 1.48e-18 Inflammatory skin disease; BRCA cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg11764359 chr7:65958608 NA -0.75 -16.8 -0.55 9.56e-53 Aortic root size; BRCA cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -9.87 -0.36 1.72e-21 Mood instability; BRCA cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg19678392 chr7:94953810 PON1 -0.43 -9.19 -0.34 5.6e-19 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs637571 0.584 rs659824 chr11:65636509 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.48 -10.23 -0.38 7.34e-23 Eosinophil percentage of white cells; BRCA trans rs629535 0.773 rs72654090 chr8:70118666 G/A cg21567404 chr3:27674614 NA -0.97 -20.42 -0.63 9.69e-72 Dupuytren's disease; BRCA cis rs2742234 0.656 rs1864400 chr10:43610366 G/A cg02780029 chr10:43622663 RET -0.37 -8.41 -0.32 2.69e-16 Hirschsprung disease; BRCA cis rs9470366 0.772 rs9918353 chr6:36622677 A/C cg08179530 chr6:36648295 CDKN1A 0.51 10.21 0.37 9.18e-23 QRS duration; BRCA cis rs514406 0.792 rs481440 chr1:53344976 C/T cg08859206 chr1:53392774 SCP2 -0.6 -13.35 -0.47 4.76e-36 Monocyte count; BRCA cis rs782590 0.764 rs2054728 chr2:55818419 C/T cg18811423 chr2:55921094 PNPT1 0.68 20.77 0.63 1.27e-73 Metabolic syndrome; BRCA cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.94 0.3 9.23e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg19318889 chr4:1322082 MAEA -0.48 -10.01 -0.37 5.14e-22 Obesity-related traits; BRCA cis rs7927771 0.864 rs2293577 chr11:47437202 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.29 0.35 2.34e-19 Subjective well-being; BRCA cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.14e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs7408868 0.764 rs45504393 chr19:15277010 A/G cg14696996 chr19:15285081 NOTCH3 0.99 14.49 0.5 2.35e-41 Pulse pressure; BRCA cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg24558204 chr6:135376177 HBS1L 0.54 14.87 0.51 3.45e-43 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg21747090 chr2:27597821 SNX17 0.4 8.57 0.32 7.86e-17 Total body bone mineral density; BRCA cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.74 11.76 0.42 4.72e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg00852783 chr1:26633632 UBXN11 -0.51 -12.21 -0.43 5.82e-31 Obesity-related traits; BRCA trans rs877282 0.898 rs11253352 chr10:766598 C/A cg22713356 chr15:30763199 NA 1.32 25.69 0.71 1.56e-100 Uric acid levels; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17270561 0.609 rs9358884 chr6:25756592 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.8e-17 Iron status biomarkers; BRCA cis rs2635047 0.934 rs11663321 chr18:44622704 T/C cg19077165 chr18:44547161 KATNAL2 -0.43 -9.07 -0.34 1.41e-18 Educational attainment; BRCA cis rs7727544 0.684 rs611084 chr5:131709739 A/C cg24060327 chr5:131705240 SLC22A5 0.47 9.48 0.35 4.75e-20 Blood metabolite levels; BRCA cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg12082025 chr19:1064218 ABCA7 -0.44 -9.41 -0.35 8.61e-20 Alzheimer's disease (late onset); BRCA cis rs4766646 0.640 rs4766488 chr12:110296095 G/C cg01252219 chr12:110302105 GLTP 0.36 7.83 0.3 1.98e-14 Metabolite levels (MHPG); BRCA cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg22987457 chr7:157211561 NA 0.33 7.97 0.3 7.1e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs9400271 0.527 rs9386798 chr6:109639971 T/C cg01475377 chr6:109611718 NA 0.36 7.96 0.3 7.82e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7178424 1.000 rs17205463 chr15:62381413 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.19 -0.31 1.44e-15 Height; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg24101359 chr6:42928495 GNMT 0.55 12.61 0.45 1.01e-32 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg18876405 chr7:65276391 NA -0.56 -13.4 -0.47 3.02e-36 Aortic root size; BRCA cis rs9290065 0.519 rs7613316 chr3:160674533 A/G cg03342759 chr3:160939853 NMD3 -0.46 -9.46 -0.35 5.94e-20 Kawasaki disease; BRCA cis rs2882667 0.858 rs35812969 chr5:138377550 G/C cg04439458 chr5:138467593 SIL1 -0.43 -10.72 -0.39 8.66e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -11.28 -0.41 5e-27 Alzheimer's disease; BRCA cis rs875971 0.545 rs316328 chr7:65608838 A/G cg11764359 chr7:65958608 NA -0.66 -13.1 -0.46 6.86e-35 Aortic root size; BRCA cis rs4423214 0.840 rs3794057 chr11:71186744 G/A cg05163923 chr11:71159392 DHCR7 -0.56 -11.35 -0.41 2.58e-27 Vitamin D levels; BRCA cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg17330251 chr7:94953956 PON1 -0.43 -8.9 -0.33 5.89e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6430585 0.527 rs62168836 chr2:136463117 G/A cg07169764 chr2:136633963 MCM6 1.01 19.31 0.61 9.06e-66 Corneal structure; BRCA cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.75 0.36 5.01e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs919433 0.890 rs979020 chr2:198169749 T/C cg03934865 chr2:198174659 NA -0.41 -8.86 -0.33 7.61e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs526821 0.595 rs608964 chr11:55339266 G/A cg11707556 chr5:10655725 ANKRD33B -0.36 -8.02 -0.3 5.15e-15 Pediatric bone mineral density (spine); BRCA trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.23 0.54 7.75e-50 Intelligence (multi-trait analysis); BRCA cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.6 9.05 0.34 1.69e-18 Lung function (FEV1/FVC); BRCA cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg06238570 chr21:40685208 BRWD1 -0.41 -8.3 -0.31 6.11e-16 Cognitive function; BRCA trans rs2235573 0.625 rs139905 chr22:38409596 C/T cg19894588 chr14:64061835 NA -0.32 -8.02 -0.3 5.09e-15 Glioblastoma;Glioma; BRCA trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg13010199 chr12:38710504 ALG10B 0.49 9.61 0.36 1.61e-20 Morning vs. evening chronotype; BRCA trans rs28735056 0.563 rs55642704 chr18:77688124 C/T cg05926928 chr17:57297772 GDPD1 -0.43 -7.82 -0.3 2.15e-14 Schizophrenia; BRCA cis rs16958440 0.867 rs12326412 chr18:44683594 A/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg08807892 chr2:162101083 NA -0.46 -8.18 -0.31 1.51e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); BRCA cis rs3925075 0.966 rs7195945 chr16:31344309 T/C cg02846316 chr16:31340340 ITGAM 0.54 13.33 0.47 5.89e-36 IgA nephropathy; BRCA cis rs6450176 0.625 rs16881958 chr5:53288201 C/G ch.5.1024479R chr5:53302184 ARL15 -0.67 -15.2 -0.52 9.03e-45 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs73086581 1.000 rs17214949 chr20:3940952 T/C cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg24642439 chr20:33292090 TP53INP2 0.42 8.73 0.33 2.15e-17 Height; BRCA cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.29 -0.41 4.39e-27 IgG glycosylation; BRCA cis rs1065656 0.571 rs2745170 chr16:1835231 G/T cg09540102 chr16:1822124 NME3;MRPS34;EME2 0.36 8.34 0.31 4.41e-16 Insulin-like growth factors; BRCA cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg09998033 chr7:158218633 PTPRN2 -0.4 -9.1 -0.34 1.1e-18 Obesity-related traits; BRCA cis rs11098499 0.954 rs10017543 chr4:120321420 G/A cg09307838 chr4:120376055 NA 0.73 15.81 0.53 9.12e-48 Corneal astigmatism; BRCA cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg03060546 chr3:49711283 APEH 0.6 9.83 0.36 2.5e-21 Menarche (age at onset); BRCA cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.31 0.31 5.96e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1401999 0.690 rs3805112 chr3:183645662 C/T cg01324343 chr3:183735012 ABCC5 0.63 15.0 0.51 8.8e-44 Anterior chamber depth; BRCA cis rs7267979 1.000 rs2482911 chr20:25395528 T/C cg08601574 chr20:25228251 PYGB -0.38 -9.09 -0.34 1.28e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.47e-49 Alzheimer's disease (late onset); BRCA cis rs2204008 0.623 rs1663281 chr12:38120936 A/G cg26384229 chr12:38710491 ALG10B -0.46 -10.54 -0.38 4.58e-24 Bladder cancer; BRCA cis rs9420 0.925 rs78587207 chr11:57654991 T/G cg19752551 chr11:57585705 CTNND1 -0.53 -12.84 -0.45 9.43e-34 Schizophrenia; BRCA cis rs1595825 0.891 rs1851779 chr2:198647108 C/T cg19156104 chr2:198669113 PLCL1 -0.42 -7.97 -0.3 7.13e-15 Ulcerative colitis; BRCA trans rs11039798 0.588 rs584899 chr11:48431408 T/C cg15704280 chr7:45808275 SEPT13 -0.48 -8.17 -0.31 1.66e-15 Axial length; BRCA cis rs2549003 1.000 rs17848418 chr5:131821188 C/T cg02551604 chr5:131831745 NA -0.4 -14.98 -0.51 1.03e-43 Asthma (sex interaction); BRCA cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 7e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg11843238 chr5:131593191 PDLIM4 0.34 8.92 0.33 4.82e-18 Breast cancer; BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg12444411 chr7:2802554 GNA12 -0.36 -8.98 -0.33 3.1e-18 Height; BRCA cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.2 0.49 5.58e-40 Motion sickness; BRCA cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg06115741 chr20:33292138 TP53INP2 0.39 8.64 0.32 4.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs4713118 0.586 rs6905516 chr6:28086478 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Parkinson's disease; BRCA cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg10802521 chr3:52805072 NEK4 -0.34 -9.32 -0.35 1.84e-19 Bipolar disorder; BRCA cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg18132916 chr6:79620363 NA -0.47 -10.45 -0.38 1.06e-23 Intelligence (multi-trait analysis); BRCA cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg01181863 chr3:195395398 SDHAP2 -0.46 -8.07 -0.3 3.56e-15 Pancreatic cancer; BRCA cis rs9818758 0.607 rs13077498 chr3:49313978 C/T cg00383909 chr3:49044727 WDR6 0.75 12.18 0.43 7.55e-31 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9309473 1.000 rs6755241 chr2:73641364 C/T cg20560298 chr2:73613845 ALMS1 -0.45 -11.14 -0.4 1.88e-26 Metabolite levels; BRCA cis rs13040088 1.000 rs12480117 chr20:61558274 G/A cg23096297 chr20:61557774 DIDO1 0.93 19.15 0.6 6.41e-65 Menopause (age at onset); BRCA cis rs8017423 1.000 rs4900028 chr14:90685594 C/T cg04374321 chr14:90722782 PSMC1 0.71 18.43 0.59 3.71e-61 Mortality in heart failure; BRCA cis rs11971779 0.793 rs4728464 chr7:139017670 C/T cg07862535 chr7:139043722 LUC7L2 -0.42 -11.51 -0.41 5.66e-28 Diisocyanate-induced asthma; BRCA cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg01119278 chr6:110721349 DDO 0.39 9.56 0.35 2.5e-20 Platelet distribution width; BRCA cis rs709400 0.633 rs3783395 chr14:103895020 T/C cg12935359 chr14:103987150 CKB -0.58 -13.84 -0.48 2.86e-38 Body mass index; BRCA cis rs4595586 0.525 rs4450203 chr12:39381493 T/G cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.68e-19 Morning vs. evening chronotype; BRCA cis rs698813 0.555 rs7605771 chr2:44479778 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.16 0.31 1.79e-15 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg21770322 chr7:97807741 LMTK2 0.43 10.98 0.4 7.84e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs490234 0.812 rs4838286 chr9:128460057 G/A cg14078157 chr9:128172775 NA -0.43 -9.72 -0.36 6.54e-21 Mean arterial pressure; BRCA cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg06212747 chr3:49208901 KLHDC8B 0.46 9.56 0.35 2.45e-20 Parkinson's disease; BRCA cis rs11696845 0.626 rs4810439 chr20:43377870 C/G cg25301532 chr20:43378953 KCNK15 -0.45 -10.89 -0.4 1.89e-25 Obesity-related traits; BRCA cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg25427524 chr10:38739819 LOC399744 -0.55 -12.48 -0.44 3.85e-32 Extrinsic epigenetic age acceleration; BRCA trans rs9409565 0.826 rs9409550 chr9:97223294 C/G cg05679027 chr9:99775184 HIATL2 -0.43 -9.4 -0.35 9.82e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg25427524 chr10:38739819 LOC399744 0.66 16.21 0.54 9.22e-50 Extrinsic epigenetic age acceleration; BRCA cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg18876405 chr7:65276391 NA 0.47 9.96 0.37 8.3e-22 Calcium levels; BRCA cis rs7572733 0.515 rs6724526 chr2:198858401 A/G cg00792783 chr2:198669748 PLCL1 0.44 9.68 0.36 9.05e-21 Dermatomyositis; BRCA cis rs425277 0.628 rs262668 chr1:2082602 A/G cg24578937 chr1:2090814 PRKCZ 0.38 11.65 0.42 1.42e-28 Height; BRCA cis rs2637266 1.000 rs7082587 chr10:78386328 C/T cg18941641 chr10:78392320 NA 0.34 7.88 0.3 1.46e-14 Pulmonary function; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg05863683 chr7:1912471 MAD1L1 0.38 8.41 0.32 2.77e-16 Bipolar disorder and schizophrenia; BRCA cis rs7647973 1.000 rs1982861 chr3:49577665 A/G cg07636037 chr3:49044803 WDR6 0.71 15.39 0.52 1.02e-45 Menarche (age at onset); BRCA cis rs4566357 0.615 rs6436644 chr2:227914275 T/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.14 -0.31 2.13e-15 Coronary artery disease; BRCA cis rs4481887 0.861 rs10888345 chr1:248447533 A/G cg00666640 chr1:248458726 OR2T12 0.33 8.82 0.33 1.11e-17 Common traits (Other); BRCA cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg27446573 chr6:127587934 RNF146 0.9 21.24 0.64 3.9e-76 Breast cancer; BRCA cis rs2171564 0.791 rs9852197 chr3:112442538 T/A cg06685282 chr3:112453648 NA 0.36 8.65 0.32 4.23e-17 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs514406 0.830 rs533935 chr1:53308807 T/C cg16325326 chr1:53192061 ZYG11B 0.69 17.55 0.57 1.44e-56 Monocyte count; BRCA trans rs8073060 0.586 rs7212488 chr17:33993476 A/T cg19694781 chr19:47549865 TMEM160 -1.05 -22.33 -0.66 4.41e-82 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs11577318 0.853 rs4450008 chr1:26643860 C/A cg07461501 chr17:79650226 HGS;ARL16 0.4 9.92 0.37 1.18e-21 Granulocyte percentage of myeloid white cells; BRCA cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg00701064 chr4:6280414 WFS1 -0.62 -15.9 -0.53 3.18e-48 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4891159 0.584 rs690397 chr18:74117767 C/T cg24786174 chr18:74118243 ZNF516 0.84 26.04 0.72 1.91e-102 Longevity; BRCA cis rs7819412 0.540 rs2409726 chr8:11043138 T/C cg21775007 chr8:11205619 TDH -0.51 -10.14 -0.37 1.71e-22 Triglycerides; BRCA cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg20607798 chr8:58055168 NA 0.53 8.34 0.31 4.56e-16 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg02297831 chr4:17616191 MED28 0.36 7.88 0.3 1.43e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg23248424 chr5:179741104 GFPT2 -0.65 -13.59 -0.47 3.92e-37 Height; BRCA cis rs1712517 0.873 rs1712516 chr10:105033628 G/A cg05636881 chr10:105038444 INA 0.36 7.91 0.3 1.17e-14 Migraine; BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg05863683 chr7:1912471 MAD1L1 0.4 8.44 0.32 2.17e-16 Bipolar disorder and schizophrenia; BRCA cis rs4820539 0.966 rs5996470 chr22:23483255 G/A cg14186256 chr22:23484241 RTDR1 0.81 25.53 0.71 1.17e-99 Bone mineral density; BRCA cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg11752832 chr7:134001865 SLC35B4 0.55 14.41 0.5 6.01e-41 Mean platelet volume; BRCA cis rs17376456 0.877 rs9314100 chr5:93447394 T/C cg21475434 chr5:93447410 FAM172A 0.69 9.03 0.34 1.97e-18 Diabetic retinopathy; BRCA cis rs11958404 0.932 rs72816556 chr5:157424412 C/G cg05962755 chr5:157440814 NA 0.49 9.61 0.36 1.64e-20 IgG glycosylation; BRCA cis rs7940866 0.834 rs1594821 chr11:130835883 C/T cg12179176 chr11:130786555 SNX19 0.61 13.63 0.47 2.56e-37 Schizophrenia; BRCA cis rs453301 0.686 rs3989373 chr8:8911308 G/T cg06636001 chr8:8085503 FLJ10661 -0.47 -10.06 -0.37 3.32e-22 Joint mobility (Beighton score); BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg27170947 chr2:26402098 FAM59B 0.97 17.16 0.56 1.38e-54 Gut microbiome composition (summer); BRCA cis rs10465746 0.780 rs11163866 chr1:84367123 A/G cg10977910 chr1:84465055 TTLL7 0.56 11.7 0.42 8.62e-29 Obesity-related traits; BRCA cis rs6450176 0.909 rs6884936 chr5:53293198 T/C ch.5.1024479R chr5:53302184 ARL15 -0.59 -13.85 -0.48 2.33e-38 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs11711311 1.000 rs9879760 chr3:113457948 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs6878727 0.665 rs173958 chr5:123675242 G/T cg01806427 chr5:123737813 NA -0.36 -8.07 -0.3 3.41e-15 Breast cancer; BRCA cis rs3008870 1.000 rs12044278 chr1:67460977 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs705471 0.966 rs12573508 chr10:3656268 C/T cg14308648 chr10:3568949 NA 0.35 7.88 0.3 1.38e-14 Capecitabine sensitivity; BRCA cis rs6977660 0.714 rs10260866 chr7:19793151 T/C cg05791153 chr7:19748676 TWISTNB 0.67 11.97 0.43 5.91e-30 Thyroid stimulating hormone; BRCA cis rs12950390 0.893 rs11079789 chr17:45849715 A/G cg24803719 chr17:45855879 NA -0.33 -8.59 -0.32 6.46e-17 IgG glycosylation; BRCA cis rs7560272 0.538 rs13000788 chr2:73918312 C/T cg20560298 chr2:73613845 ALMS1 0.35 9.06 0.34 1.53e-18 Schizophrenia; BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg11062466 chr8:58055876 NA 0.5 8.88 0.33 6.54e-18 Developmental language disorder (linguistic errors); BRCA cis rs12711979 0.692 rs6751947 chr2:3820739 G/A cg17052675 chr2:3827356 NA -0.48 -14.26 -0.49 2.93e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 8.95 0.33 3.75e-18 Tonsillectomy; BRCA trans rs6089829 1.000 rs6089828 chr20:61668998 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.53 0.32 1.08e-16 Prostate cancer (SNP x SNP interaction); BRCA trans rs11098499 0.820 rs28578366 chr4:120536905 A/G cg25214090 chr10:38739885 LOC399744 -0.53 -11.74 -0.42 6.17e-29 Corneal astigmatism; BRCA cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg15103426 chr22:29168792 CCDC117 0.52 12.2 0.43 6.37e-31 Lymphocyte counts; BRCA cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg24088639 chr11:34937564 PDHX;APIP -0.39 -8.84 -0.33 9.31e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg26031613 chr14:104095156 KLC1 -0.42 -8.46 -0.32 1.86e-16 Schizophrenia; BRCA cis rs11984145 1.000 rs68175808 chr7:38832209 G/A cg19327137 chr7:38886074 VPS41 0.46 7.83 0.3 2.07e-14 Cognitive performance; BRCA cis rs919433 0.680 rs788017 chr2:198265173 T/A cg00792783 chr2:198669748 PLCL1 0.38 8.55 0.32 9.31e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg20607798 chr8:58055168 NA 0.61 9.75 0.36 4.75e-21 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg01579765 chr21:45077557 HSF2BP 0.4 10.57 0.39 3.62e-24 Mean corpuscular volume; BRCA cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19346786 chr7:2764209 NA -0.26 -8.0 -0.3 5.86e-15 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA trans rs11039798 0.925 rs10769373 chr11:48531980 T/A cg15704280 chr7:45808275 SEPT13 0.56 8.34 0.31 4.74e-16 Axial length; BRCA cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.67 0.36 9.72e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs7615952 0.641 rs12487875 chr3:125787224 C/A cg07211511 chr3:129823064 LOC729375 -0.63 -11.17 -0.4 1.39e-26 Blood pressure (smoking interaction); BRCA cis rs7818345 1.000 rs4430112 chr8:19293365 G/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.95 0.3 8.41e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg02466173 chr16:30829666 NA -0.49 -11.22 -0.41 8.58e-27 Dementia with Lewy bodies; BRCA cis rs1832871 0.672 rs56075516 chr6:158745752 G/A cg07165851 chr6:158734300 TULP4 0.63 12.61 0.45 9.79e-33 Height; BRCA cis rs61990749 0.597 rs8003691 chr14:78211225 A/G cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.88 0.3 1.38e-14 Fibroblast growth factor basic levels; BRCA cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg11764359 chr7:65958608 NA 0.74 16.66 0.55 4.99e-52 Aortic root size; BRCA cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg10523679 chr1:76189770 ACADM 0.76 15.88 0.53 4.12e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg10011062 chr15:43941034 CATSPER2 0.51 8.25 0.31 8.83e-16 Lung cancer in ever smokers; BRCA cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.13 0.49 1.22e-39 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs965469 1.000 rs2236122 chr20:3305240 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -10.26 -0.38 5.74e-23 IFN-related cytopenia; BRCA cis rs11690935 0.527 rs7586556 chr2:172901887 G/C cg13550731 chr2:172543902 DYNC1I2 0.58 14.43 0.5 4.74e-41 Schizophrenia; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.56 -0.39 3.98e-24 Lymphocyte counts; BRCA cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg03146154 chr1:46216737 IPP 0.44 9.72 0.36 6.39e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg13319975 chr6:146136371 FBXO30 -0.35 -8.25 -0.31 9.4e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs853679 0.517 rs3823180 chr6:28061744 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.17e-15 Depression; BRCA trans rs12439619 1.000 rs12439619 chr15:82546946 T/G cg04831495 chr15:85060580 GOLGA6L5 -0.42 -10.72 -0.39 9.14e-25 Intelligence (multi-trait analysis); BRCA cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg00701064 chr4:6280414 WFS1 0.68 17.03 0.56 6.41e-54 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs12310956 0.531 rs10772110 chr12:33841755 A/G cg26384229 chr12:38710491 ALG10B 0.39 8.72 0.33 2.45e-17 Morning vs. evening chronotype; BRCA cis rs757110 0.648 rs12146443 chr11:17384498 T/C cg03864215 chr11:17408437 KCNJ11 -0.27 -8.01 -0.3 5.41e-15 Type 2 diabetes; BRCA cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg12311346 chr5:56204834 C5orf35 -0.81 -16.16 -0.54 1.65e-49 Initial pursuit acceleration; BRCA cis rs1878931 0.697 rs10048148 chr16:3417450 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.9 22.74 0.67 2.56e-84 Body mass index (adult); BRCA cis rs4595586 0.545 rs7136002 chr12:39369168 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs12472274 0.941 rs6748440 chr2:239100375 C/T cg17459225 chr2:239074497 NA 0.63 12.87 0.45 7.58e-34 Phospholipid levels (plasma); BRCA cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg21399703 chr1:247681439 NA 0.42 9.37 0.35 1.22e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs9814567 0.806 rs4074521 chr3:134325536 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.54 16.56 0.55 1.58e-51 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9400271 0.527 rs9400274 chr6:109639876 G/A cg01475377 chr6:109611718 NA 0.36 7.96 0.3 7.82e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs3818285 1.000 rs3740138 chr10:111630931 C/T cg00817464 chr10:111662876 XPNPEP1 -0.36 -8.94 -0.33 4.19e-18 Superior crus of antihelix expression; BRCA cis rs1420338 0.933 rs731844 chr7:34150264 C/T cg01275685 chr7:34179230 BMPER -0.52 -11.7 -0.42 8.48e-29 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04155289 chr7:94953770 PON1 -0.53 -11.44 -0.41 1.05e-27 Paraoxonase activity; BRCA trans rs9951602 0.512 rs73494176 chr18:76644895 T/C cg02800362 chr5:177631904 HNRNPAB 0.76 17.68 0.57 3.16e-57 Obesity-related traits; BRCA cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -11.89 -0.43 1.33e-29 Mood instability; BRCA trans rs208515 0.525 rs12191500 chr6:66668681 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 16.01 0.54 9.02e-49 Exhaled nitric oxide levels; BRCA cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs11764590 0.715 rs9969125 chr7:2088460 C/T cg02743256 chr7:2109353 MAD1L1 -0.45 -7.98 -0.3 6.75e-15 Neuroticism; BRCA cis rs10197940 0.578 rs6718653 chr2:152346118 C/A cg19508488 chr2:152266495 RIF1 0.37 7.93 0.3 9.6e-15 Lung cancer; BRCA cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg13319975 chr6:146136371 FBXO30 0.41 9.35 0.35 1.51e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4268898 0.662 rs72793213 chr2:24524725 A/G cg06627628 chr2:24431161 ITSN2 -0.78 -14.72 -0.5 1.86e-42 Asthma; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.57 11.98 0.43 5.64e-30 Lymphocyte counts; BRCA cis rs9858542 0.953 rs11922013 chr3:49458355 G/C cg03060546 chr3:49711283 APEH -0.54 -10.91 -0.4 1.61e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs861020 1.000 rs630984 chr1:209982293 C/T cg05527609 chr1:210001259 C1orf107 0.68 14.53 0.5 1.54e-41 Orofacial clefts; BRCA cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg22974920 chr21:40686053 BRWD1 -0.38 -8.62 -0.32 5.12e-17 Cognitive function; BRCA cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg11189052 chr15:85197271 WDR73 0.44 8.93 0.33 4.54e-18 Schizophrenia; BRCA cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg18876405 chr7:65276391 NA 0.7 18.65 0.59 2.72e-62 Aortic root size; BRCA cis rs6743226 0.901 rs12478458 chr2:242237856 A/G cg10021735 chr2:242295487 FARP2 0.37 10.12 0.37 1.95e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg20573242 chr4:122745356 CCNA2 0.46 9.82 0.36 2.76e-21 Type 2 diabetes; BRCA cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg16230307 chr14:35515116 FAM177A1 0.74 15.31 0.52 2.58e-45 Psoriasis; BRCA cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg01884057 chr2:25150051 NA 0.34 8.49 0.32 1.43e-16 Body mass index; BRCA cis rs9527 0.590 rs10786738 chr10:104869451 C/T cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.13e-24 Arsenic metabolism; BRCA cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg26031613 chr14:104095156 KLC1 0.73 15.88 0.53 3.91e-48 Body mass index; BRCA cis rs1003719 0.751 rs56268364 chr21:38542765 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.08 -0.49 2.11e-39 Eye color traits; BRCA cis rs4629180 1.000 rs59246268 chr2:102089021 G/A cg04415270 chr2:102091202 RFX8 -0.33 -8.32 -0.31 5.14e-16 Chronic rhinosinusitis with nasal polyps; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.71 15.55 0.52 1.74e-46 Lymphocyte counts; BRCA cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.41 -8.99 -0.34 2.69e-18 IgG glycosylation; BRCA cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.6 12.3 0.44 2.41e-31 Monocyte percentage of white cells; BRCA cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg26597838 chr10:835615 NA 0.9 13.67 0.48 1.64e-37 Eosinophil percentage of granulocytes; BRCA cis rs17401966 0.838 rs6541089 chr1:10402785 A/G cg19773385 chr1:10388646 KIF1B -0.35 -7.81 -0.3 2.31e-14 Hepatocellular carcinoma; BRCA cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg00409905 chr10:38381863 ZNF37A -0.43 -8.99 -0.34 2.67e-18 Extrinsic epigenetic age acceleration; BRCA cis rs701145 0.585 rs1727945 chr3:153882865 G/A cg17054900 chr3:154042577 DHX36 0.56 9.46 0.35 5.73e-20 Coronary artery disease; BRCA cis rs870825 0.860 rs60523653 chr4:185604676 T/C cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs1983170 1.000 rs12563578 chr1:91993702 T/C cg25838465 chr1:92012736 NA 0.47 9.24 0.34 3.51e-19 Eosinophil percentage of white cells; BRCA cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg21747090 chr2:27597821 SNX17 -0.39 -8.55 -0.32 9.37e-17 Total body bone mineral density; BRCA cis rs921968 0.565 rs6745700 chr2:219639862 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.02 -0.4 5.7e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs2180341 0.920 rs6916990 chr6:127698759 G/A cg24812749 chr6:127587940 RNF146 0.88 20.06 0.62 9.03e-70 Breast cancer; BRCA cis rs4073582 0.595 rs1115508 chr11:65923149 A/G cg16950941 chr11:66035639 RAB1B 0.43 11.85 0.42 1.99e-29 Gout; BRCA cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02018176 chr4:1364513 KIAA1530 -0.39 -8.23 -0.31 1.07e-15 Longevity; BRCA cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg14844989 chr11:31128820 NA -0.45 -9.77 -0.36 4.21e-21 Red blood cell count; BRCA trans rs35110281 0.659 rs73367822 chr21:45024252 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.22 0.31 1.11e-15 Mean corpuscular volume; BRCA cis rs17253792 0.545 rs12894613 chr14:56016221 T/C cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg08493051 chr2:3487164 NA -0.43 -9.25 -0.34 3.33e-19 Neurofibrillary tangles; BRCA cis rs4363385 0.747 rs1129655 chr1:152958267 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.72 -0.33 2.43e-17 Inflammatory skin disease; BRCA trans rs7824557 0.836 rs765731 chr8:11121498 T/A cg08975724 chr8:8085496 FLJ10661 -0.44 -8.34 -0.31 4.7e-16 Retinal vascular caliber; BRCA cis rs7100689 0.577 rs756208 chr10:82041751 A/G cg01528321 chr10:82214614 TSPAN14 0.78 17.03 0.56 6.88e-54 Post bronchodilator FEV1; BRCA cis rs600806 0.850 rs1465607 chr1:109958035 T/C cg20591472 chr1:110008990 SYPL2 0.32 7.91 0.3 1.12e-14 Intelligence (multi-trait analysis); BRCA cis rs11626933 1.000 rs2236402 chr14:90734378 C/G cg04374321 chr14:90722782 PSMC1 0.42 8.24 0.31 9.48e-16 Gut microbiota (bacterial taxa); BRCA cis rs9399137 0.507 rs11759077 chr6:135381351 A/G cg22676075 chr6:135203613 NA 0.45 8.89 0.33 6.22e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs61931739 0.613 rs1525898 chr12:33904445 G/T cg06521331 chr12:34319734 NA -0.39 -7.85 -0.3 1.71e-14 Morning vs. evening chronotype; BRCA cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg08601574 chr20:25228251 PYGB 0.35 8.36 0.31 3.92e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg05834845 chr3:195489306 MUC4 -0.56 -8.51 -0.32 1.22e-16 Lung disease severity in cystic fibrosis; BRCA cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.65 0.42 1.48e-28 Schizophrenia; BRCA cis rs56104184 0.775 rs73061697 chr19:49400000 C/T cg15549821 chr19:49342101 PLEKHA4 -0.67 -9.72 -0.36 6.19e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs7103648 1.000 rs12292911 chr11:47449072 C/T cg03711944 chr11:47377212 SPI1 -0.41 -11.06 -0.4 3.75e-26 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.34 0.38 2.83e-23 Aortic root size; BRCA cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg01939980 chr4:1354348 KIAA1530 0.38 9.11 0.34 1.02e-18 Obesity-related traits; BRCA cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.25e-18 Motion sickness; BRCA trans rs61931739 0.534 rs11052959 chr12:33997095 T/C cg13010199 chr12:38710504 ALG10B 0.47 8.99 0.34 2.82e-18 Morning vs. evening chronotype; BRCA cis rs6740322 0.895 rs6544643 chr2:43560072 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -12.59 -0.45 1.23e-32 Coronary artery disease; BRCA cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg21427119 chr20:30132790 HM13 -0.41 -8.78 -0.33 1.53e-17 Mean corpuscular hemoglobin; BRCA cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg24069376 chr3:38537580 EXOG 0.32 8.97 0.33 3.13e-18 Electrocardiographic conduction measures; BRCA cis rs807669 0.586 rs5746671 chr22:19160899 A/G cg02655711 chr22:19163373 SLC25A1 0.48 11.16 0.4 1.48e-26 Metabolite levels; BRCA cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg24531977 chr5:56204891 C5orf35 -0.89 -19.09 -0.6 1.23e-64 Initial pursuit acceleration; BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg00149659 chr3:10157352 C3orf10 1.06 18.2 0.58 6.23e-60 Alzheimer's disease; BRCA cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -11.75 -0.42 5.31e-29 Personality dimensions; BRCA cis rs250677 1.000 rs250677 chr5:148433549 T/C cg23229984 chr5:148520753 ABLIM3 0.31 7.81 0.3 2.36e-14 Breast cancer; BRCA cis rs11677370 0.603 rs10164826 chr2:3849951 G/C cg17052675 chr2:3827356 NA -0.54 -12.99 -0.46 2.01e-34 Type 2 diabetes; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg11062466 chr8:58055876 NA 0.49 8.67 0.32 3.64e-17 Developmental language disorder (linguistic errors); BRCA cis rs7572733 0.555 rs6434954 chr2:198929716 T/C cg00792783 chr2:198669748 PLCL1 0.36 7.99 0.3 6.43e-15 Dermatomyositis; BRCA cis rs7512552 0.839 rs1260405 chr1:150304781 A/G cg15654264 chr1:150340011 RPRD2 0.41 9.05 0.34 1.73e-18 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs9486715 1.000 rs9386670 chr6:97060688 C/A cg06623918 chr6:96969491 KIAA0776 -0.82 -19.9 -0.62 6.31e-69 Headache; BRCA cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg03060546 chr3:49711283 APEH 0.6 10.31 0.38 3.56e-23 Menarche (age at onset); BRCA cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA trans rs11098499 0.955 rs1551 chr4:120158500 T/G cg25214090 chr10:38739885 LOC399744 0.48 10.58 0.39 3.28e-24 Corneal astigmatism; BRCA cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg03433033 chr1:76189801 ACADM -0.6 -11.84 -0.42 2.22e-29 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg23505145 chr19:12996616 KLF1 0.56 12.64 0.45 7.94e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg05283184 chr6:79620031 NA -0.44 -11.31 -0.41 3.85e-27 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs9287719 0.967 rs7600587 chr2:10739851 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs11711311 1.000 rs11711311 chr3:113430599 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 10.7 0.39 1.11e-24 IgG glycosylation; BRCA cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.62 13.81 0.48 3.96e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg00677455 chr12:58241039 CTDSP2 0.47 11.52 0.41 5.01e-28 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg23711669 chr6:146136114 FBXO30 -0.7 -16.49 -0.55 3.76e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg26408565 chr15:76604113 ETFA -0.47 -10.06 -0.37 3.32e-22 Blood metabolite levels; BRCA cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.6 12.04 0.43 3.05e-30 Multiple sclerosis; BRCA cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg25358565 chr5:93447407 FAM172A 1.21 18.85 0.6 2.32e-63 Diabetic retinopathy; BRCA cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg21475434 chr5:93447410 FAM172A 0.67 8.72 0.33 2.36e-17 Diabetic retinopathy; BRCA cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg03517284 chr6:25882590 NA -0.47 -10.55 -0.39 4.14e-24 Blood metabolite levels; BRCA cis rs2635047 0.648 rs4986203 chr18:44597092 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 9.05 0.34 1.65e-18 Educational attainment; BRCA cis rs912057 0.932 rs1294406 chr6:6737737 A/G cg06612196 chr6:6737390 NA 0.46 10.49 0.38 7.19e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA trans rs1973993 0.669 rs510552 chr1:96891671 A/G cg10631902 chr5:14652156 NA 0.59 21.2 0.64 6.24e-76 Weight; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg00990874 chr7:1149470 C7orf50 -0.62 -13.13 -0.46 5.1e-35 Bronchopulmonary dysplasia; BRCA trans rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05039488 chr6:79577232 IRAK1BP1 0.37 8.33 0.31 4.98e-16 Endometrial cancer; BRCA cis rs7824557 0.767 rs1897951 chr8:11169854 C/T cg21775007 chr8:11205619 TDH 0.61 11.98 0.43 5.7e-30 Retinal vascular caliber; BRCA trans rs6952808 0.564 rs73038441 chr7:2139286 T/C cg04565464 chr8:145669602 NFKBIL2 0.44 9.86 0.36 1.89e-21 Bipolar disorder and schizophrenia; BRCA cis rs7582180 0.790 rs4851288 chr2:100920451 T/C cg14675211 chr2:100938903 LONRF2 0.47 10.19 0.37 1.09e-22 Intelligence (multi-trait analysis); BRCA cis rs7927771 0.524 rs7929725 chr11:47881740 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.53 0.35 3.18e-20 Subjective well-being; BRCA trans rs7746199 0.736 rs56405707 chr6:27640246 G/A cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.96e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg21475434 chr5:93447410 FAM172A 0.69 9.37 0.35 1.21e-19 Diabetic retinopathy; BRCA cis rs7824557 0.836 rs765731 chr8:11121498 T/A cg21775007 chr8:11205619 TDH -0.6 -11.74 -0.42 5.93e-29 Retinal vascular caliber; BRCA cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg11764359 chr7:65958608 NA 0.78 18.59 0.59 5.33e-62 Aortic root size; BRCA trans rs2727020 0.558 rs1164675 chr11:49325972 C/T cg03929089 chr4:120376271 NA 0.71 16.15 0.54 1.82e-49 Coronary artery disease; BRCA cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg17971929 chr21:40555470 PSMG1 -0.61 -13.39 -0.47 3.24e-36 Cognitive function; BRCA cis rs17604090 0.877 rs57253003 chr7:29686556 T/C cg19413766 chr7:29689036 LOC646762 -0.51 -7.98 -0.3 6.76e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs12530845 0.887 rs78641973 chr7:135324311 C/T cg23117316 chr7:135346802 PL-5283 -0.35 -8.26 -0.31 8.45e-16 Red blood cell traits; BRCA cis rs870825 0.616 rs7683537 chr4:185631998 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA cis rs3820928 1.000 rs4675116 chr2:227769607 A/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.56 -0.32 8.49e-17 Pulmonary function; BRCA cis rs11997175 0.583 rs17780153 chr8:33789161 A/G ch.8.33884649F chr8:33765107 NA 0.37 8.3 0.31 6.26e-16 Body mass index; BRCA cis rs17384381 0.953 rs12122816 chr1:85792384 C/T cg16011679 chr1:85725395 C1orf52 0.54 8.17 0.31 1.69e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs1005277 0.579 rs2749612 chr10:38488610 G/A cg17830980 chr10:43048298 ZNF37B -0.56 -13.7 -0.48 1.21e-37 Extrinsic epigenetic age acceleration; BRCA cis rs1020064 0.945 rs1030878 chr2:105910598 T/G cg02079111 chr2:105885981 TGFBRAP1 0.63 11.86 0.42 1.76e-29 AIDS; BRCA cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.19 0.52 9.72e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.955 rs7685268 chr4:120162188 G/A cg25214090 chr10:38739885 LOC399744 0.48 10.66 0.39 1.53e-24 Corneal astigmatism; BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg01262667 chr19:19385393 TM6SF2 0.41 10.54 0.38 4.75e-24 Tonsillectomy; BRCA cis rs897080 0.515 rs698791 chr2:44683168 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.54 9.43 0.35 7.39e-20 Height; BRCA trans rs1994135 0.630 rs11052757 chr12:33719879 A/G cg13010199 chr12:38710504 ALG10B 0.43 7.99 0.3 6.18e-15 Resting heart rate; BRCA cis rs7945718 0.806 rs7927346 chr11:12835835 C/T cg25843174 chr11:12811716 TEAD1 0.21 8.34 0.31 4.6e-16 Educational attainment (years of education); BRCA cis rs9486719 1.000 rs12201449 chr6:96959382 C/T cg06623918 chr6:96969491 KIAA0776 -0.73 -13.08 -0.46 8.41e-35 Migraine;Coronary artery disease; BRCA cis rs9329289 0.926 rs10903784 chr10:2541943 G/T cg15501526 chr10:2543763 NA -0.57 -13.99 -0.48 5.6e-39 Age-related hearing impairment; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg20801007 chr11:830320 EFCAB4A -0.49 -10.72 -0.39 9.01e-25 Mean platelet volume; BRCA cis rs4820539 0.966 rs2301554 chr22:23484254 A/C cg14186256 chr22:23484241 RTDR1 0.82 25.75 0.71 7.97e-101 Bone mineral density; BRCA cis rs3806843 1.000 rs10072015 chr5:140170655 A/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.46 0.35 5.61e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs7809799 1.000 rs6969313 chr7:98754007 G/A cg05967295 chr7:98741636 SMURF1 -0.81 -8.04 -0.3 4.24e-15 Ulcerative colitis; BRCA cis rs3125734 0.633 rs7100297 chr10:63985100 T/C cg19640130 chr10:64028056 RTKN2 -0.29 -8.38 -0.31 3.27e-16 Rheumatoid arthritis; BRCA cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.72 11.11 0.4 2.34e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 11.08 0.4 3.19e-26 Personality dimensions; BRCA cis rs965469 0.857 rs1922990 chr20:3252348 G/A cg25506879 chr20:3388711 C20orf194 -0.45 -9.1 -0.34 1.12e-18 IFN-related cytopenia; BRCA cis rs7246657 0.943 rs4803460 chr19:37885228 T/C cg18154014 chr19:37997991 ZNF793 0.49 9.72 0.36 6.14e-21 Coronary artery calcification; BRCA cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg18876405 chr7:65276391 NA -0.51 -11.75 -0.42 5.48e-29 Aortic root size; BRCA cis rs3008870 1.000 rs2815348 chr1:67472165 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.83 0.65 2.21e-79 Lymphocyte percentage of white cells; BRCA cis rs17376456 0.569 rs7713956 chr5:93133185 T/C cg25358565 chr5:93447407 FAM172A -0.67 -11.7 -0.42 8.73e-29 Diabetic retinopathy; BRCA cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg06784218 chr1:46089804 CCDC17 -0.54 -13.14 -0.46 4.5e-35 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.9 -0.3 1.26e-14 Corneal astigmatism; BRCA cis rs12541635 0.966 rs12681183 chr8:107007156 T/A cg10147462 chr8:107024639 NA 0.37 9.98 0.37 6.74e-22 Age of smoking initiation; BRCA cis rs9399135 0.967 rs10872427 chr6:135353452 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.29 0.44 2.61e-31 Red blood cell count; BRCA trans rs208520 0.690 rs4618506 chr6:66756889 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.96 -20.2 -0.62 1.49e-70 Exhaled nitric oxide output; BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg00814883 chr7:100076585 TSC22D4 -0.47 -10.45 -0.38 1.06e-23 Platelet count; BRCA cis rs921968 0.541 rs10205073 chr2:219412784 C/A cg10223061 chr2:219282414 VIL1 0.3 8.68 0.32 3.39e-17 Mean corpuscular hemoglobin concentration; BRCA trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg25214090 chr10:38739885 LOC399744 0.54 12.24 0.44 4.06e-31 Corneal astigmatism; BRCA cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg00631329 chr6:26305371 NA -0.44 -13.0 -0.46 1.8e-34 Educational attainment; BRCA cis rs6545883 0.929 rs1186700 chr2:61663372 A/C cg15711740 chr2:61764176 XPO1 -0.51 -12.33 -0.44 1.81e-31 Tuberculosis; BRCA cis rs9790314 0.586 rs35713426 chr3:161131271 A/G cg04691961 chr3:161091175 C3orf57 -0.38 -8.91 -0.33 5.14e-18 Morning vs. evening chronotype; BRCA cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg24562669 chr7:97807699 LMTK2 0.45 11.98 0.43 5.55e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg03452623 chr4:187889614 NA -0.34 -11.62 -0.42 1.81e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs9400271 0.632 rs9374071 chr6:109588681 T/C cg21918786 chr6:109611834 NA -0.32 -8.09 -0.3 3.08e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs2516839 0.517 rs1556257 chr1:161051134 A/G cg23055938 chr1:160991191 F11R -0.44 -8.44 -0.32 2.19e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9399135 0.967 rs7773126 chr6:135318390 A/G cg24558204 chr6:135376177 HBS1L 0.44 11.85 0.42 2.03e-29 Red blood cell count; BRCA cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg18479299 chr3:125709523 NA -0.53 -8.18 -0.31 1.53e-15 Blood pressure (smoking interaction); BRCA cis rs3892630 0.588 rs28787932 chr19:33226229 T/C cg22980127 chr19:33182716 NUDT19 0.92 20.5 0.63 3.92e-72 Red blood cell traits; BRCA cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs2204008 0.546 rs11519978 chr12:37998170 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.41e-22 Bladder cancer; BRCA cis rs929596 0.785 rs6747843 chr2:234664354 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -12.05 -0.43 2.92e-30 Total bilirubin levels in HIV-1 infection; BRCA cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg19678392 chr7:94953810 PON1 -0.43 -9.08 -0.34 1.38e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.02 0.3 4.91e-15 Corneal astigmatism; BRCA cis rs6060717 0.536 rs11699815 chr20:34543125 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.0 -0.3 5.95e-15 Hip circumference adjusted for BMI; BRCA cis rs11690935 0.959 rs3770451 chr2:172668715 T/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -29.81 -0.76 4.77e-123 Schizophrenia; BRCA cis rs1003719 0.788 rs2835576 chr21:38457393 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.18 0.49 7.11e-40 Eye color traits; BRCA cis rs3916 0.911 rs2239758 chr12:121162637 A/G cg21892295 chr12:121157589 UNC119B -0.38 -9.95 -0.37 8.62e-22 Urinary metabolites (H-NMR features); BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg10729496 chr3:10149963 C3orf24 0.51 9.1 0.34 1.17e-18 Alzheimer's disease; BRCA cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg21573476 chr21:45109991 RRP1B -0.33 -8.68 -0.32 3.25e-17 Mean corpuscular volume; BRCA cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.06 -0.3 3.78e-15 Bipolar disorder; BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg27170947 chr2:26402098 FAM59B 0.84 12.18 0.43 8.02e-31 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.53 -0.32 1.05e-16 Gut microbiome composition (summer); BRCA trans rs11722228 1.000 rs4697695 chr4:9915850 C/T cg26043149 chr18:55253948 FECH 0.6 13.51 0.47 9.41e-37 Gout;Urate levels;Serum uric acid levels; BRCA cis rs12348691 0.503 rs7046645 chr9:100617375 T/C cg13688889 chr9:100608707 NA -0.49 -9.9 -0.36 1.32e-21 Alopecia areata; BRCA cis rs3815700 1.000 rs8100168 chr19:33093084 G/A cg02997394 chr19:33096574 ANKRD27 0.61 8.67 0.32 3.58e-17 Eosinophilic esophagitis; BRCA cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg27478167 chr7:817139 HEATR2 0.53 10.41 0.38 1.46e-23 Cerebrospinal P-tau181p levels; BRCA cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg15448220 chr1:150897856 SETDB1 0.36 8.02 0.3 5.06e-15 Melanoma; BRCA trans rs7395662 0.818 rs2200181 chr11:48413175 C/G cg00717180 chr2:96193071 NA -0.29 -7.93 -0.3 9.78e-15 HDL cholesterol; BRCA cis rs939658 0.683 rs8024572 chr15:79465600 A/G cg17916960 chr15:79447300 NA 0.36 8.61 0.32 5.55e-17 Refractive error; BRCA cis rs3857067 0.806 rs2171384 chr4:95103545 G/A cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.34 -0.35 1.56e-19 QT interval; BRCA cis rs17376456 0.877 rs114256265 chr5:93473130 T/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.09 0.3 2.97e-15 Diabetic retinopathy; BRCA cis rs9302690 0.557 rs223875 chr16:57506915 C/T cg16753122 chr16:57506917 DOK4 0.47 7.86 0.3 1.58e-14 Blood protein levels; BRCA cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.81 0.39 3.99e-25 Rheumatoid arthritis; BRCA cis rs9369695 0.842 rs9395262 chr6:47465267 T/C cg12968598 chr6:47444699 CD2AP 0.44 9.68 0.36 9.34e-21 Reticulocyte count; BRCA cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg24450063 chr1:156163899 SLC25A44 1.11 36.3 0.82 2.03e-157 Testicular germ cell tumor; BRCA cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg02951883 chr7:2050386 MAD1L1 -0.45 -10.04 -0.37 4.19e-22 Bipolar disorder and schizophrenia; BRCA cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.01 0.34 2.37e-18 Lymphocyte counts; BRCA cis rs45509595 0.841 rs200501 chr6:27788942 C/T cg26587870 chr6:27730563 NA -0.52 -8.05 -0.3 4.11e-15 Breast cancer; BRCA cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg10523679 chr1:76189770 ACADM 0.76 15.89 0.53 3.87e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7766436 0.885 rs7742025 chr6:22575798 A/T cg13666174 chr6:22585274 NA -0.45 -9.76 -0.36 4.67e-21 Coronary artery disease; BRCA cis rs11252926 0.565 rs4881308 chr10:484983 G/T cg03684893 chr10:554711 DIP2C -0.4 -9.6 -0.36 1.71e-20 Psychosis in Alzheimer's disease; BRCA cis rs13064411 0.501 rs13092925 chr3:113209375 C/G cg18753928 chr3:113234510 CCDC52 -0.46 -9.92 -0.37 1.14e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.21 0.49 4.93e-40 Colorectal cancer; BRCA trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg15704280 chr7:45808275 SEPT13 0.56 8.77 0.33 1.67e-17 Intraocular pressure; BRCA cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg11498726 chr8:26250323 BNIP3L 0.59 14.82 0.51 6.01e-43 Red cell distribution width; BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg04025307 chr7:1156635 C7orf50 0.57 9.96 0.37 8.36e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.99 0.33 2.85e-18 Tonsillectomy; BRCA cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg26838691 chr2:24397539 C2orf84 -0.44 -8.3 -0.31 6.21e-16 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs1669338 0.588 rs73005226 chr3:3195369 A/G cg16797762 chr3:3221439 CRBN -0.58 -9.11 -0.34 1.06e-18 White matter integrity; BRCA cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs6963495 0.818 rs6944787 chr7:105147309 C/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.07e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6714710 0.603 rs11680321 chr2:98379267 C/T cg26665480 chr2:98280029 ACTR1B 0.56 13.05 0.46 1.11e-34 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs35306767 0.855 rs12774985 chr10:904245 C/T cg10556349 chr10:835070 NA 0.75 10.06 0.37 3.24e-22 Eosinophil percentage of granulocytes; BRCA cis rs61931739 0.534 rs4086956 chr12:34105047 A/T cg06521331 chr12:34319734 NA -0.62 -12.2 -0.43 6.08e-31 Morning vs. evening chronotype; BRCA trans rs6582630 0.537 rs11520294 chr12:38402705 C/A cg06521331 chr12:34319734 NA -0.51 -9.28 -0.34 2.52e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg20887711 chr4:1340912 KIAA1530 0.48 11.21 0.41 9.38e-27 Longevity; BRCA cis rs3768617 0.811 rs4366285 chr1:183013672 T/G ch.1.3577855R chr1:183094577 LAMC1 0.46 9.97 0.37 7.54e-22 Fuchs's corneal dystrophy; BRCA cis rs4561483 0.798 rs33629 chr16:11997490 G/A cg08843971 chr16:11963173 GSPT1 -0.45 -9.45 -0.35 6.4e-20 Testicular germ cell tumor; BRCA cis rs7917772 0.582 rs7906115 chr10:104327164 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.87 14.34 0.49 1.3e-40 Alzheimer's disease; BRCA cis rs651907 0.737 rs9844218 chr3:101584983 C/T cg12386194 chr3:101231763 SENP7 -0.43 -8.56 -0.32 8.35e-17 Colorectal cancer; BRCA cis rs11955398 0.716 rs56191602 chr5:59954444 T/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.46e-19 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg13010199 chr12:38710504 ALG10B 0.44 9.31 0.35 1.98e-19 Morning vs. evening chronotype; BRCA cis rs10411936 0.712 rs8100755 chr19:16593415 G/A cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.74 0.36 5.51e-21 White blood cell count;Multiple sclerosis; BRCA cis rs10493773 0.609 rs10873716 chr1:86178347 G/T cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.36 -0.47 4.41e-36 Urate levels in overweight individuals; BRCA cis rs6598955 0.671 rs6686100 chr1:26617338 G/C cg04990556 chr1:26633338 UBXN11 0.54 8.9 0.33 5.55e-18 Obesity-related traits; BRCA cis rs6964587 0.626 rs10280301 chr7:91524258 A/T cg17063962 chr7:91808500 NA -0.55 -12.71 -0.45 3.76e-33 Breast cancer; BRCA cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg12310025 chr6:25882481 NA 0.42 9.45 0.35 6.29e-20 Intelligence (multi-trait analysis); BRCA cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.4 9.26 0.34 3.15e-19 Multiple sclerosis; BRCA cis rs16854884 0.657 rs16854816 chr3:143734147 A/G cg06585982 chr3:143692056 C3orf58 0.43 9.0 0.34 2.63e-18 Economic and political preferences (feminism/equality); BRCA cis rs734999 1.000 rs10797432 chr1:2501338 C/T cg18854424 chr1:2615690 NA 0.31 8.22 0.31 1.12e-15 Ulcerative colitis; BRCA cis rs7098414 0.530 rs4146515 chr10:82116602 G/A cg00277334 chr10:82204260 NA -0.44 -9.25 -0.34 3.42e-19 Post bronchodilator FEV1; BRCA cis rs958025 1 rs958025 chr15:78759348 C/T cg24631222 chr15:78858424 CHRNA5 0.5 9.77 0.36 4.31e-21 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs9467773 1.000 rs28558133 chr6:26531433 G/C cg11502198 chr6:26597334 ABT1 0.47 9.39 0.35 9.98e-20 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg03517284 chr6:25882590 NA 0.38 8.22 0.31 1.1e-15 Intelligence (multi-trait analysis); BRCA cis rs801193 0.773 rs801207 chr7:66020590 T/C cg18876405 chr7:65276391 NA -0.58 -13.71 -0.48 1.06e-37 Aortic root size; BRCA cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg21918786 chr6:109611834 NA -0.48 -13.79 -0.48 4.72e-38 Reticulocyte fraction of red cells; BRCA cis rs7312933 0.558 rs7305397 chr12:42850058 T/C cg01256987 chr12:42539512 GXYLT1 -0.42 -7.85 -0.3 1.79e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs344364 0.511 rs1742464 chr16:1947335 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.54 9.49 0.35 4.59e-20 Glomerular filtration rate in chronic kidney disease; BRCA cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg20573242 chr4:122745356 CCNA2 0.49 11.15 0.4 1.62e-26 Type 2 diabetes; BRCA cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg05347473 chr6:146136440 FBXO30 0.55 10.26 0.38 5.59e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg17971929 chr21:40555470 PSMG1 -0.48 -10.57 -0.39 3.68e-24 Menarche (age at onset); BRCA cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg12386194 chr3:101231763 SENP7 0.65 12.82 0.45 1.23e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg26395211 chr5:140044315 WDR55 0.38 8.65 0.32 4.25e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs9640161 0.711 rs3800781 chr7:150027324 T/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.56 -13.7 -0.48 1.18e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg13902645 chr11:5959945 NA -0.45 -8.8 -0.33 1.24e-17 DNA methylation (variation); BRCA cis rs208520 1.000 rs12191598 chr6:66983962 T/C cg07460842 chr6:66804631 NA 0.88 14.29 0.49 2.04e-40 Exhaled nitric oxide output; BRCA cis rs7727544 0.606 rs11950562 chr5:131652529 A/C cg14196790 chr5:131705035 SLC22A5 0.5 13.08 0.46 8.41e-35 Blood metabolite levels; BRCA trans rs7944735 0.507 rs7114598 chr11:48101766 C/T cg15704280 chr7:45808275 SEPT13 0.43 8.13 0.31 2.23e-15 Intraocular pressure; BRCA cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg12591125 chr7:1885375 MAD1L1 0.51 8.92 0.33 5.05e-18 Bipolar disorder; BRCA cis rs9986765 1.000 rs73452567 chr7:142816043 T/G cg15652212 chr7:142981776 TMEM139 0.64 10.06 0.37 3.47e-22 Cancer;Dermatomyositis; BRCA trans rs7647973 0.626 rs1996664 chr3:49878395 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.38 7.9 0.3 1.18e-14 Menarche (age at onset); BRCA cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -13.08 -0.46 8.23e-35 Bipolar disorder; BRCA cis rs9443189 0.570 rs659807 chr6:76293435 C/A cg01950844 chr6:76311363 SENP6 0.85 14.09 0.49 1.77e-39 Prostate cancer; BRCA cis rs9790314 0.580 rs960212 chr3:161047974 C/T cg03342759 chr3:160939853 NMD3 -0.63 -13.99 -0.48 5.29e-39 Morning vs. evening chronotype; BRCA cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg06060754 chr5:176797920 RGS14 -0.79 -15.44 -0.52 6.19e-46 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs7408868 1.000 rs7245814 chr19:15274503 A/G cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs68170813 0.522 rs12531187 chr7:106963650 C/G cg02696742 chr7:106810147 HBP1 -0.53 -8.47 -0.32 1.7e-16 Coronary artery disease; BRCA cis rs6005807 0.719 rs9625513 chr22:29022172 C/T cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA trans rs634534 0.622 rs624273 chr11:65712413 A/G cg17712092 chr4:129076599 LARP1B 0.51 12.04 0.43 3.15e-30 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs9309473 0.607 rs7560272 chr2:73561485 A/T cg20560298 chr2:73613845 ALMS1 -0.44 -11.65 -0.42 1.39e-28 Metabolite levels; BRCA cis rs6964587 0.743 rs33993294 chr7:91998655 A/C cg17063962 chr7:91808500 NA 0.53 11.71 0.42 7.83e-29 Breast cancer; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg08280861 chr8:58055591 NA 0.53 8.59 0.32 6.53e-17 Developmental language disorder (linguistic errors); BRCA cis rs9462027 0.628 rs9296127 chr6:34719628 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.39e-15 Systemic lupus erythematosus; BRCA trans rs3741489 1.000 rs4758915 chr12:133477147 A/G cg24132527 chr5:140019269 TMCO6 0.97 10.3 0.38 3.94e-23 Cognitive function; BRCA cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg02574844 chr11:5959923 NA -0.41 -8.2 -0.31 1.36e-15 DNA methylation (variation); BRCA cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.28 -0.31 7.1e-16 Bipolar disorder; BRCA cis rs7565124 0.909 rs6747473 chr2:20252008 C/G cg23821541 chr2:20251993 LAPTM4A 0.39 8.23 0.31 1.02e-15 Major depressive disorder; BRCA cis rs3008870 1.000 rs11208979 chr1:67442275 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs1568889 0.838 rs10835283 chr11:28214985 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.57 0.63 1.62e-72 Bipolar disorder; BRCA cis rs9790314 0.589 rs13097130 chr3:160669279 G/A cg03342759 chr3:160939853 NMD3 0.46 8.72 0.33 2.47e-17 Morning vs. evening chronotype; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg22920501 chr2:26401640 FAM59B 0.9 16.59 0.55 1.12e-51 Gut microbiome composition (summer); BRCA cis rs7568458 0.684 rs7593969 chr2:85809670 A/G cg02493740 chr2:85810744 VAMP5 0.55 11.44 0.41 1.06e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11644478 chr21:40555479 PSMG1 -0.69 -15.64 -0.53 6.64e-47 Cognitive function; BRCA trans rs9467711 0.659 rs35433030 chr6:26529890 G/A cg01620082 chr3:125678407 NA -0.7 -8.74 -0.33 2e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg11584989 chr19:19387371 SF4 0.63 13.4 0.47 2.87e-36 Bipolar disorder; BRCA cis rs7560272 0.501 rs2421676 chr2:73966087 G/A cg20560298 chr2:73613845 ALMS1 0.34 8.58 0.32 6.99e-17 Schizophrenia; BRCA cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg01884057 chr2:25150051 NA 0.34 8.49 0.32 1.4e-16 Body mass index; BRCA cis rs36051895 0.658 rs11999928 chr9:5006743 T/G cg02405213 chr9:5042618 JAK2 -0.47 -8.78 -0.33 1.49e-17 Pediatric autoimmune diseases; BRCA cis rs10463316 0.894 rs7712569 chr5:150766089 A/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.29 -0.31 6.58e-16 Metabolite levels (Pyroglutamine); BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg27170947 chr2:26402098 FAM59B -0.66 -11.62 -0.42 1.91e-28 Gut microbiome composition (summer); BRCA cis rs757278 0.608 rs11767185 chr7:117345652 G/A cg10524701 chr7:117356490 CTTNBP2 0.43 7.81 0.3 2.42e-14 Response to methotrexate in juvenile idiopathic arthritis; BRCA cis rs7267979 1.000 rs2258879 chr20:25279213 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.2e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19346786 chr7:2764209 NA -0.28 -8.71 -0.33 2.66e-17 Height; BRCA cis rs701145 0.585 rs1713822 chr3:153863505 A/G cg17054900 chr3:154042577 DHX36 0.55 9.23 0.34 3.79e-19 Coronary artery disease; BRCA cis rs2637266 0.967 rs12254242 chr10:78352934 T/C cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.29e-14 Pulmonary function; BRCA cis rs6598955 0.671 rs7417505 chr1:26575523 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg04727924 chr7:799746 HEATR2 -0.56 -11.14 -0.4 1.83e-26 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6598955 0.671 rs6658935 chr1:26568912 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.34 0.44 1.64e-31 Platelet count; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg22638593 chr5:131593259 PDLIM4 0.32 7.86 0.3 1.7e-14 Acylcarnitine levels; BRCA cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs473651 0.935 rs477041 chr2:239355995 C/G cg03560586 chr2:239334908 ASB1 0.49 10.97 0.4 9.14e-26 Multiple system atrophy; BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg04709771 chr16:646395 RAB40C 0.44 11.32 0.41 3.33e-27 Height; BRCA cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg08807101 chr21:30365312 RNF160 0.72 18.73 0.6 9.67e-63 Dental caries; BRCA cis rs870825 0.616 rs7654208 chr4:185648877 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 11.25 0.41 6.6e-27 Personality dimensions; BRCA cis rs6964587 1.000 rs2299232 chr7:91626699 A/C cg01689657 chr7:91764605 CYP51A1 0.23 8.32 0.31 5.27e-16 Breast cancer; BRCA cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.43e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9831754 0.856 rs9824624 chr3:78407182 G/A cg06138941 chr3:78371609 NA -0.74 -15.99 -0.53 1.21e-48 Calcium levels; BRCA cis rs7246657 0.551 rs10419174 chr19:37605341 A/G cg18154014 chr19:37997991 ZNF793 0.52 8.38 0.31 3.49e-16 Coronary artery calcification; BRCA cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.46 0.38 9.44e-24 Mean corpuscular volume; BRCA trans rs9858542 0.953 rs11706370 chr3:49441091 G/A cg21659725 chr3:3221576 CRBN -0.45 -9.59 -0.35 1.86e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg08999081 chr20:33150536 PIGU 0.47 13.11 0.46 6.3e-35 Glomerular filtration rate (creatinine); BRCA cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg26343298 chr8:95960752 TP53INP1 0.29 8.22 0.31 1.17e-15 Type 2 diabetes; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg04267008 chr7:1944627 MAD1L1 0.68 15.16 0.51 1.39e-44 Bipolar disorder and schizophrenia; BRCA cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg24977027 chr2:88469347 THNSL2 0.53 9.0 0.34 2.63e-18 Plasma clusterin levels; BRCA trans rs3733585 0.699 rs2018643 chr4:9947121 C/T cg26043149 chr18:55253948 FECH 0.36 8.0 0.3 5.96e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg03676636 chr4:99064102 C4orf37 0.22 8.04 0.3 4.24e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.58 0.32 7.01e-17 Rheumatoid arthritis; BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg04267008 chr7:1944627 MAD1L1 -0.61 -13.2 -0.46 2.48e-35 Bipolar disorder and schizophrenia; BRCA cis rs17401966 0.838 rs12139981 chr1:10390696 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.86 0.48 2.33e-38 Hepatocellular carcinoma; BRCA cis rs2191566 0.614 rs396497 chr19:44494430 A/T cg20607764 chr19:44506953 ZNF230 -0.39 -8.05 -0.3 3.99e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs7267979 1.000 rs2257991 chr20:25270339 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.35 -0.31 4.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg00814883 chr7:100076585 TSC22D4 -0.48 -10.01 -0.37 5.03e-22 Platelet count; BRCA cis rs17092148 0.945 rs17092080 chr20:33335657 A/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.31 -0.41 3.74e-27 Neuroticism; BRCA cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg27535305 chr1:53392650 SCP2 0.32 8.07 0.3 3.4e-15 Monocyte count; BRCA cis rs2464469 0.631 rs2704218 chr15:58345001 A/T cg12031962 chr15:58353849 ALDH1A2 -0.32 -8.26 -0.31 8.53e-16 Barrett's esophagus or Esophageal adenocarcinoma; BRCA cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -9.09 -0.34 1.2e-18 Personality dimensions; BRCA cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22509189 chr2:225307070 NA -0.43 -9.14 -0.34 8.36e-19 IgE levels in asthmatics (D.p. specific); BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs877282 1.000 rs12775643 chr10:773242 G/A cg17470449 chr10:769945 NA 0.49 9.32 0.35 1.83e-19 Uric acid levels; BRCA cis rs6815814 0.950 rs5743566 chr4:38805942 G/C cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 14.7 0.5 2.49e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg10523679 chr1:76189770 ACADM 0.69 12.71 0.45 3.59e-33 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg15017067 chr4:17643749 FAM184B -0.3 -8.4 -0.32 2.86e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs34779708 0.931 rs11010067 chr10:35295431 C/G cg03585969 chr10:35415529 CREM -0.44 -9.13 -0.34 8.67e-19 Inflammatory bowel disease;Crohn's disease; BRCA trans rs1493916 0.748 rs7230463 chr18:31309133 G/C cg15819921 chr19:927150 ARID3A -0.41 -8.24 -0.31 9.8e-16 Life satisfaction; BRCA cis rs2580764 0.678 rs2580765 chr2:55204028 A/C cg09592903 chr2:55203963 RTN4 0.43 10.95 0.4 1.08e-25 Mean platelet volume; BRCA cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg15017067 chr4:17643749 FAM184B 0.32 9.94 0.37 9.73e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6964587 1.000 rs3753108 chr7:91629984 T/G cg17063962 chr7:91808500 NA 0.57 13.5 0.47 1.01e-36 Breast cancer; BRCA cis rs30380 0.587 rs469674 chr5:96130015 G/C cg16492584 chr5:96139282 ERAP1 -0.45 -10.49 -0.38 7.32e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs3008870 1.000 rs2755244 chr1:67484470 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.91 -20.39 -0.63 1.51e-71 Lymphocyte percentage of white cells; BRCA cis rs4730250 0.707 rs1981696 chr7:106794100 C/T cg02696742 chr7:106810147 HBP1 0.51 8.41 0.32 2.68e-16 Osteoarthritis; BRCA trans rs11098499 0.954 rs10014845 chr4:120301077 T/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg06636001 chr8:8085503 FLJ10661 0.67 15.33 0.52 2.16e-45 Mood instability; BRCA cis rs7072216 0.763 rs10883092 chr10:100167276 A/C cg26618903 chr10:100175079 PYROXD2 -0.3 -8.86 -0.33 7.61e-18 Metabolite levels; BRCA cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Smoking initiation; BRCA cis rs10791097 0.694 rs4436551 chr11:130755739 A/G cg12179176 chr11:130786555 SNX19 -0.69 -17.38 -0.57 1.07e-55 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg13902645 chr11:5959945 NA 0.46 10.15 0.37 1.48e-22 DNA methylation (variation); BRCA cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg23018236 chr17:30244563 NA -0.66 -10.02 -0.37 4.74e-22 Hip circumference adjusted for BMI; BRCA cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg13010199 chr12:38710504 ALG10B 0.36 8.62 0.32 5.15e-17 Morning vs. evening chronotype; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg15112475 chr7:1198522 ZFAND2A -0.42 -8.18 -0.31 1.58e-15 Bronchopulmonary dysplasia; BRCA cis rs12310956 0.532 rs11052951 chr12:33986181 T/A cg06521331 chr12:34319734 NA -0.53 -10.6 -0.39 2.71e-24 Morning vs. evening chronotype; BRCA cis rs751728 0.571 rs4713691 chr6:33790415 A/G cg25922239 chr6:33757077 LEMD2 -0.39 -8.43 -0.32 2.21e-16 Crohn's disease; BRCA cis rs12711979 0.509 rs1031478 chr2:3827425 G/A cg17052675 chr2:3827356 NA -0.71 -24.21 -0.69 2.14e-92 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 11.19 0.4 1.15e-26 Mean platelet volume; BRCA cis rs2742234 0.590 rs2115817 chr10:43686552 C/T cg15436174 chr10:43711423 RASGEF1A -0.55 -11.25 -0.41 6.37e-27 Hirschsprung disease; BRCA cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg11644478 chr21:40555479 PSMG1 0.61 9.37 0.35 1.18e-19 Cognitive function; BRCA cis rs12579753 0.917 rs7132732 chr12:82206053 C/G cg07988820 chr12:82153109 PPFIA2 -0.5 -8.77 -0.33 1.58e-17 Resting heart rate; BRCA cis rs2243480 0.614 rs34032527 chr7:65565141 C/G cg18252515 chr7:66147081 NA -1.07 -15.54 -0.52 2.03e-46 Diabetic kidney disease; BRCA trans rs61931739 0.513 rs1463634 chr12:33899621 A/G cg13010199 chr12:38710504 ALG10B 0.38 8.38 0.31 3.45e-16 Morning vs. evening chronotype; BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.57 0.39 3.57e-24 Tonsillectomy; BRCA cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg03433033 chr1:76189801 ACADM -0.59 -11.68 -0.42 1.1e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9287719 0.934 rs12692416 chr2:10745627 A/G cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs4268898 0.552 rs7560342 chr2:24371691 T/C cg26838691 chr2:24397539 C2orf84 0.4 8.1 0.31 2.86e-15 Asthma; BRCA cis rs3806843 0.900 rs2563286 chr5:140125199 T/A cg11822812 chr5:140052017 DND1 -0.31 -8.58 -0.32 7.38e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs7520050 0.931 rs1707333 chr1:46547035 C/G cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.42e-19 Red blood cell count;Reticulocyte count; BRCA cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg11608241 chr8:8085544 FLJ10661 0.34 9.46 0.35 6.01e-20 Mood instability; BRCA cis rs495337 0.760 rs6125830 chr20:48571662 G/A cg17835207 chr20:48524531 SPATA2 -0.68 -16.82 -0.55 7.73e-53 Psoriasis; BRCA cis rs757081 0.643 rs665311 chr11:17206740 A/T cg15432903 chr11:17409602 KCNJ11 -0.46 -8.58 -0.32 7.23e-17 Systolic blood pressure; BRCA cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg24642439 chr20:33292090 TP53INP2 0.72 16.53 0.55 2.25e-51 Coronary artery disease; BRCA cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg01884057 chr2:25150051 NA 0.34 9.22 0.34 4.2e-19 Body mass index; BRCA cis rs701145 0.878 rs355753 chr3:153968846 T/C cg17054900 chr3:154042577 DHX36 0.67 11.71 0.42 8.15e-29 Coronary artery disease; BRCA cis rs9300255 0.722 rs12298826 chr12:123829028 A/G cg00376283 chr12:123451042 ABCB9 -0.49 -11.21 -0.41 9.52e-27 Neutrophil percentage of white cells; BRCA cis rs11690935 0.550 rs62183801 chr2:172867475 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 12.11 0.43 1.55e-30 Schizophrenia; BRCA cis rs6964587 0.692 rs10236483 chr7:91797296 A/C cg17063962 chr7:91808500 NA 0.58 13.45 0.47 1.7e-36 Breast cancer; BRCA cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg15595755 chr5:1867978 NA 0.36 8.61 0.32 5.48e-17 Cardiovascular disease risk factors; BRCA trans rs12310956 0.515 rs1830086 chr12:33958874 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs7246967 0.551 rs6511367 chr19:22821270 G/A cg23217946 chr19:22817039 ZNF492 0.47 8.48 0.32 1.56e-16 Bronchopulmonary dysplasia; BRCA cis rs17604090 0.775 rs10225523 chr7:29689735 C/A cg19413766 chr7:29689036 LOC646762 -0.51 -8.22 -0.31 1.11e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs2204008 0.688 rs12824232 chr12:38175901 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA trans rs877282 0.583 rs11595057 chr10:819203 A/C cg22713356 chr15:30763199 NA 0.91 14.96 0.51 1.31e-43 Uric acid levels; BRCA cis rs738322 0.511 rs2267371 chr22:38577119 T/G cg25457927 chr22:38595422 NA -0.36 -12.04 -0.43 3.1e-30 Cutaneous nevi; BRCA cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.12 -0.4 2.28e-26 Extrinsic epigenetic age acceleration; BRCA cis rs765787 0.530 rs28733848 chr15:45516047 C/T cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs7590368 1.000 rs17456225 chr2:10963238 C/G cg15705551 chr2:10952987 PDIA6 0.43 8.06 0.3 3.89e-15 Educational attainment (years of education); BRCA cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg05294307 chr14:35346193 BAZ1A -0.6 -10.42 -0.38 1.37e-23 Psoriasis; BRCA cis rs705471 0.725 rs705465 chr10:3645633 G/A cg14308648 chr10:3568949 NA 0.4 10.26 0.38 5.85e-23 Capecitabine sensitivity; BRCA cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -16.97 -0.56 1.31e-53 Chronic sinus infection; BRCA cis rs9393777 0.588 rs11967935 chr6:26560672 A/C cg12826209 chr6:26865740 GUSBL1 0.54 9.51 0.35 3.8e-20 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24531977 chr5:56204891 C5orf35 -0.87 -18.47 -0.59 2.34e-61 Initial pursuit acceleration; BRCA cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.83 0.51 5.53e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg15017067 chr4:17643749 FAM184B 0.29 8.4 0.32 2.81e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs68170813 0.559 rs3801959 chr7:106955666 A/G cg02696742 chr7:106810147 HBP1 -0.54 -8.67 -0.32 3.66e-17 Coronary artery disease; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg19723775 chr5:179050963 HNRNPH1 0.45 10.66 0.39 1.6e-24 Lung cancer; BRCA cis rs9875589 0.957 rs1108341 chr3:13937328 T/A cg19554555 chr3:13937349 NA 0.42 8.68 0.32 3.4e-17 Ovarian reserve; BRCA cis rs16976116 0.901 rs28526269 chr15:55499190 A/G cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1975974 0.574 rs17052370 chr17:21736353 A/G cg18423549 chr17:21743878 NA 0.65 14.33 0.49 1.43e-40 Psoriasis; BRCA cis rs7640424 0.589 rs78673584 chr3:107813133 A/G cg09227934 chr3:107805635 CD47 -0.44 -8.28 -0.31 7.14e-16 Body mass index; BRCA cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg21770322 chr7:97807741 LMTK2 0.56 16.02 0.54 7.92e-49 Breast cancer; BRCA cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg07148914 chr20:33460835 GGT7 0.37 8.33 0.31 5.11e-16 Height; BRCA cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg17845761 chr1:175162550 KIAA0040 0.25 9.6 0.36 1.76e-20 Alcohol dependence; BRCA cis rs1878931 0.501 rs9635547 chr16:3416664 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 11.79 0.42 3.55e-29 Body mass index (adult); BRCA cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg02153584 chr22:29168773 CCDC117 0.57 11.92 0.43 1.06e-29 Lymphocyte counts; BRCA cis rs6867913 0.709 rs891987 chr5:141467196 A/T cg08523384 chr5:141488047 NDFIP1 0.35 8.64 0.32 4.55e-17 Asthma; BRCA cis rs919433 0.617 rs4850809 chr2:198583403 C/T cg00792783 chr2:198669748 PLCL1 -0.44 -9.73 -0.36 6.06e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.28 0.34 2.55e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs6543140 0.964 rs6543138 chr2:103066132 G/A cg04239558 chr2:103089729 SLC9A4 0.34 9.58 0.35 2.16e-20 Blood protein levels; BRCA cis rs7766436 0.845 rs1342207 chr6:22587762 G/A cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg00277334 chr10:82204260 NA -0.85 -24.69 -0.7 5.01e-95 Post bronchodilator FEV1; BRCA cis rs11098499 0.954 rs6849561 chr4:120409694 C/G cg09307838 chr4:120376055 NA -0.7 -14.15 -0.49 9.19e-40 Corneal astigmatism; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg00166722 chr3:10149974 C3orf24 0.63 13.07 0.46 9.55e-35 Alzheimer's disease; BRCA cis rs7520050 0.966 rs4376778 chr1:46288846 C/G cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.38e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2304069 1.000 rs2304069 chr5:149406733 G/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.47 8.0 0.3 5.89e-15 HIV-1 control; BRCA cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg11663144 chr21:46675770 NA -0.62 -14.66 -0.5 3.53e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg08213375 chr14:104286397 PPP1R13B 0.4 8.68 0.32 3.17e-17 Reticulocyte count; BRCA cis rs7809950 1.000 rs2520249 chr7:107146748 A/G cg23024343 chr7:107201750 COG5 -0.39 -9.09 -0.34 1.25e-18 Coronary artery disease; BRCA cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg26220594 chr1:19110978 NA -0.37 -7.95 -0.3 8.58e-15 Knee osteoarthritis; BRCA cis rs6964587 1.000 rs2299232 chr7:91626699 A/C cg17063962 chr7:91808500 NA 0.52 11.82 0.42 2.65e-29 Breast cancer; BRCA trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg05623727 chr3:50126028 RBM5 0.43 10.1 0.37 2.4e-22 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg02951883 chr7:2050386 MAD1L1 -0.53 -11.59 -0.42 2.6e-28 Bipolar disorder and schizophrenia; BRCA cis rs3106136 0.546 rs2664881 chr4:95143484 A/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.07 -0.37 2.97e-22 Capecitabine sensitivity; BRCA trans rs3134353 0.704 rs2386922 chr8:101975479 A/C cg20993868 chr7:22813445 NA -0.27 -8.22 -0.31 1.1e-15 Body mass index; BRCA trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg15704280 chr7:45808275 SEPT13 0.63 11.25 0.41 6.26e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24531977 chr5:56204891 C5orf35 -0.86 -18.56 -0.59 8.34e-62 Initial pursuit acceleration; BRCA cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.55 -0.35 2.8e-20 Tonsillectomy; BRCA cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.07 0.37 3.07e-22 Bipolar disorder; BRCA cis rs8114671 0.933 rs6087683 chr20:33774444 C/T cg07148914 chr20:33460835 GGT7 0.37 7.92 0.3 1.08e-14 Height; BRCA cis rs2204008 0.630 rs1283300 chr12:38150227 C/T cg26384229 chr12:38710491 ALG10B -0.46 -10.57 -0.39 3.71e-24 Bladder cancer; BRCA cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg13902645 chr11:5959945 NA -0.56 -11.45 -0.41 9.81e-28 DNA methylation (variation); BRCA cis rs7786877 0.723 rs7812123 chr7:100211556 C/A cg16850897 chr7:100343110 ZAN -0.57 -10.63 -0.39 2.09e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs3824344 0.507 rs2297105 chr9:37020622 A/C cg14294708 chr9:37120828 ZCCHC7 -0.42 -8.41 -0.32 2.7e-16 Intelligence; BRCA cis rs13053817 1.000 rs13340033 chr22:29846339 A/G cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.48 -10.06 -0.37 3.34e-22 Carotid atherosclerosis in HIV infection; BRCA cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.62 13.2 0.46 2.36e-35 Age-related macular degeneration (geographic atrophy); BRCA trans rs3857536 0.813 rs7757118 chr6:66946661 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs11603020 0.950 rs3824988 chr11:57377968 C/T cg19752551 chr11:57585705 CTNND1 0.42 9.86 0.36 1.89e-21 Blood protein levels; BRCA cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg23029597 chr12:123009494 RSRC2 -0.6 -12.45 -0.44 5.12e-32 Body mass index; BRCA cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg09035930 chr12:129282057 SLC15A4 0.53 15.21 0.52 8.15e-45 Systemic lupus erythematosus; BRCA cis rs11997175 0.545 rs66783231 chr8:33811467 A/T ch.8.33884649F chr8:33765107 NA 0.36 8.52 0.32 1.15e-16 Body mass index; BRCA cis rs10242455 0.702 rs73403290 chr7:99157828 C/T cg18809830 chr7:99032528 PTCD1 -0.61 -8.49 -0.32 1.42e-16 Blood metabolite levels; BRCA cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24308560 chr3:49941425 MST1R 0.4 8.43 0.32 2.33e-16 Intelligence (multi-trait analysis); BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg19346786 chr7:2764209 NA -0.33 -9.67 -0.36 9.83e-21 Height; BRCA cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg18876405 chr7:65276391 NA -0.56 -13.35 -0.47 5.16e-36 Aortic root size; BRCA cis rs835154 1.000 rs835154 chr5:14876569 A/G cg18064842 chr5:14874549 NA 0.4 10.3 0.38 4e-23 Blood metabolite levels; BRCA cis rs3784262 0.528 rs8027964 chr15:58335272 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.89 -0.36 1.54e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg16103275 chr6:290800 DUSP22 -0.46 -10.13 -0.37 1.78e-22 Menopause (age at onset); BRCA cis rs78487399 0.908 rs57066469 chr2:43843813 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -7.95 -0.3 8.73e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg05347473 chr6:146136440 FBXO30 0.6 11.7 0.42 8.29e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs911555 0.755 rs12435516 chr14:103954404 T/C cg24130564 chr14:104152367 KLC1 0.35 7.98 0.3 6.97e-15 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg24642439 chr20:33292090 TP53INP2 0.54 11.61 0.42 2e-28 Glomerular filtration rate (creatinine); BRCA cis rs7267979 0.808 rs84816 chr20:25459919 G/A cg08601574 chr20:25228251 PYGB 0.32 7.83 0.3 2.11e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1865760 0.865 rs9467647 chr6:25957642 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.38e-21 Height; BRCA cis rs9473147 0.571 rs9395285 chr6:47554177 G/A cg12968598 chr6:47444699 CD2AP 0.46 9.88 0.36 1.62e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.56 -0.32 8.13e-17 Developmental language disorder (linguistic errors); BRCA cis rs965469 1.000 rs6051745 chr20:3307243 T/G cg25506879 chr20:3388711 C20orf194 -0.54 -10.53 -0.38 4.92e-24 IFN-related cytopenia; BRCA cis rs10751667 0.961 rs7395303 chr11:986221 T/A ch.11.42038R chr11:967971 AP2A2 0.57 18.41 0.59 4.76e-61 Alzheimer's disease (late onset); BRCA cis rs514406 0.708 rs514881 chr1:53336737 A/G cg27535305 chr1:53392650 SCP2 0.46 11.22 0.41 8.44e-27 Monocyte count; BRCA cis rs7264396 0.563 rs7264869 chr20:34346502 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.66 -0.42 1.25e-28 Total cholesterol levels; BRCA cis rs7246657 0.943 rs4452075 chr19:37879589 A/G cg18154014 chr19:37997991 ZNF793 0.49 9.56 0.35 2.42e-20 Coronary artery calcification; BRCA cis rs950169 0.579 rs881983 chr15:84647308 C/T cg17507749 chr15:85114479 UBE2QP1 0.5 8.44 0.32 2.09e-16 Schizophrenia; BRCA trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.46 -0.38 9.46e-24 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg11764359 chr7:65958608 NA -0.64 -11.27 -0.41 5.23e-27 Aortic root size; BRCA cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg25427524 chr10:38739819 LOC399744 -0.69 -16.72 -0.55 2.55e-52 Extrinsic epigenetic age acceleration; BRCA cis rs2637030 0.533 rs7731940 chr5:52863638 A/T cg06476337 chr5:52856530 NDUFS4 0.35 7.92 0.3 1.05e-14 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg14926445 chr8:58193284 C8orf71 -0.46 -8.88 -0.33 6.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs710216 0.536 rs710221 chr1:43414200 G/A cg07803811 chr1:43423981 SLC2A1 0.42 8.98 0.33 3.1e-18 Red cell distribution width; BRCA cis rs1348850 0.526 rs78587445 chr2:178461339 G/T cg27490568 chr2:178487706 NA -0.54 -7.89 -0.3 1.3e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17023223 0.537 rs12083510 chr1:119746620 T/G cg05756136 chr1:119680316 WARS2 -0.41 -7.87 -0.3 1.51e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs12200560 0.505 rs211167 chr6:97069087 T/A cg06623918 chr6:96969491 KIAA0776 0.51 12.12 0.43 1.44e-30 Coronary heart disease; BRCA cis rs9287719 0.967 rs6432119 chr2:10753687 A/T cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg23711669 chr6:146136114 FBXO30 0.77 17.59 0.57 8.37e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs12545109 0.879 rs2670015 chr8:57376607 T/A cg09654669 chr8:57350985 NA -0.46 -8.69 -0.33 3.08e-17 Obesity-related traits; BRCA cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg11663144 chr21:46675770 NA -0.53 -12.53 -0.44 2.4e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs9325144 0.555 rs28738714 chr12:38706912 G/A cg23762105 chr12:34175262 ALG10 0.35 8.3 0.31 6.43e-16 Morning vs. evening chronotype; BRCA cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg27478167 chr7:817139 HEATR2 -0.42 -9.01 -0.34 2.28e-18 Cerebrospinal P-tau181p levels; BRCA cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.16 -0.4 1.55e-26 Schizophrenia; BRCA cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg08999081 chr20:33150536 PIGU 0.34 8.66 0.32 3.71e-17 Coronary artery disease; BRCA cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.38 -11.01 -0.4 6.33e-26 Monocyte percentage of white cells; BRCA cis rs3845702 0.736 rs72960664 chr2:180832672 C/T cg01881094 chr2:180872142 CWC22 1.01 16.69 0.55 3.51e-52 Schizophrenia; BRCA cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg22467129 chr15:76604101 ETFA -0.47 -10.15 -0.37 1.57e-22 Blood metabolite levels; BRCA cis rs6835098 0.924 rs13138282 chr4:174120906 C/T cg27433088 chr4:174089019 GALNT7 -0.33 -8.3 -0.31 6.34e-16 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24110177 chr3:50126178 RBM5 -0.4 -10.91 -0.4 1.54e-25 Intelligence (multi-trait analysis); BRCA cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg12573674 chr2:1569213 NA -0.58 -12.23 -0.44 4.78e-31 IgG glycosylation; BRCA cis rs870825 0.616 rs6814278 chr4:185644417 G/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.54 10.46 0.38 9.97e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1557765 0.527 rs2018218 chr11:17390855 A/G cg15432903 chr11:17409602 KCNJ11 0.4 8.7 0.33 2.72e-17 Body mass index;Social communication problems; BRCA cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg08917208 chr2:24149416 ATAD2B 0.52 8.07 0.3 3.37e-15 Lymphocyte counts; BRCA cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg06627628 chr2:24431161 ITSN2 -0.54 -8.89 -0.33 6.17e-18 Lymphocyte counts; BRCA cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.34 -0.44 1.64e-31 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg12927641 chr6:109611667 NA -0.39 -9.78 -0.36 3.85e-21 Reticulocyte fraction of red cells; BRCA cis rs11190604 1.000 rs2495755 chr10:102324649 A/C cg07080220 chr10:102295463 HIF1AN 0.63 13.39 0.47 3.18e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12497850 0.931 rs62262517 chr3:49134914 T/G cg06212747 chr3:49208901 KLHDC8B 0.48 9.61 0.36 1.57e-20 Parkinson's disease; BRCA cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.52 0.41 4.8e-28 Coronary artery disease; BRCA cis rs9790314 0.663 rs6804650 chr3:160648953 A/G cg03342759 chr3:160939853 NMD3 -0.44 -8.27 -0.31 8.02e-16 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs9289478 chr3:134268619 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.06 -0.34 1.62e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg05347473 chr6:146136440 FBXO30 0.61 12.02 0.43 3.84e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg04455712 chr21:45112962 RRP1B 0.41 10.45 0.38 1.05e-23 Mean corpuscular volume; BRCA cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg10495392 chr1:46806563 NSUN4 0.45 8.34 0.31 4.65e-16 Menopause (age at onset); BRCA cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg22875332 chr1:76189707 ACADM 0.68 14.74 0.5 1.52e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg03060546 chr3:49711283 APEH 0.6 10.31 0.38 3.56e-23 Menarche (age at onset); BRCA cis rs9419702 0.568 rs7075233 chr10:133545170 A/G cg04492858 chr10:133558786 NA -0.34 -8.02 -0.3 5.17e-15 Survival in rectal cancer; BRCA cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.47e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24308560 chr3:49941425 MST1R -0.39 -8.1 -0.31 2.85e-15 Intelligence (multi-trait analysis); BRCA cis rs6545883 0.859 rs2600661 chr2:61543081 T/C cg15711740 chr2:61764176 XPO1 0.52 13.19 0.46 2.62e-35 Tuberculosis; BRCA cis rs9290065 0.538 rs9860182 chr3:160768962 T/C cg03342759 chr3:160939853 NMD3 -0.53 -10.61 -0.39 2.51e-24 Kawasaki disease; BRCA trans rs8002861 0.902 rs1445557 chr13:44464827 C/T cg17145862 chr1:211918768 LPGAT1 0.73 19.6 0.61 2.35e-67 Leprosy; BRCA cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg06115741 chr20:33292138 TP53INP2 -0.37 -8.23 -0.31 1.04e-15 Glomerular filtration rate (creatinine); BRCA trans rs6479891 1.000 rs63749191 chr10:65119887 T/C cg14819942 chr15:35414228 NA 0.34 8.27 0.31 7.58e-16 Arthritis (juvenile idiopathic); BRCA cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.23 0.41 8.1e-27 Coronary artery disease; BRCA cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg24069376 chr3:38537580 EXOG -0.33 -9.43 -0.35 7.59e-20 Electrocardiographic conduction measures; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg12927641 chr6:109611667 NA -0.42 -10.97 -0.4 8.93e-26 Reticulocyte fraction of red cells; BRCA cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.59 12.23 0.44 4.9e-31 Monocyte percentage of white cells; BRCA cis rs7091068 0.518 rs9633674 chr10:95455431 C/T cg20715218 chr10:95462985 C10orf4 0.47 9.86 0.36 1.88e-21 Urinary tract infection frequency; BRCA cis rs7246657 0.943 rs7246993 chr19:37890154 C/T cg18154014 chr19:37997991 ZNF793 0.62 11.63 0.42 1.7e-28 Coronary artery calcification; BRCA cis rs9354352 1.000 rs9354352 chr6:66696272 T/C cg07460842 chr6:66804631 NA 0.64 13.82 0.48 3.46e-38 Initial pursuit acceleration in psychotic disorders; BRCA cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg05313129 chr8:58192883 C8orf71 -0.44 -9.5 -0.35 4.13e-20 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg06064525 chr11:970664 AP2A2 -0.48 -16.02 -0.54 7.9e-49 Alzheimer's disease (late onset); BRCA cis rs10752881 0.875 rs10752894 chr1:183050610 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 17.08 0.56 3.87e-54 Colorectal cancer; BRCA cis rs36051895 0.659 rs7025540 chr9:5043152 T/C cg02405213 chr9:5042618 JAK2 -0.49 -9.18 -0.34 5.99e-19 Pediatric autoimmune diseases; BRCA cis rs7264396 0.528 rs3787174 chr20:34487921 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -11.47 -0.41 8.32e-28 Total cholesterol levels; BRCA trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg22491629 chr6:157744540 C6orf35 -0.64 -11.71 -0.42 7.75e-29 Hemostatic factors and hematological phenotypes; BRCA cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.59 0.35 1.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.35 7.86 0.3 1.68e-14 Platelet count; BRCA cis rs1969363 0.509 rs8189633 chr12:38065155 C/G cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.42e-22 Morning vs. evening chronotype; BRCA cis rs1003719 0.788 rs3787782 chr21:38462909 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs7301826 0.627 rs61937256 chr12:131302645 G/A cg11011512 chr12:131303247 STX2 -0.45 -11.23 -0.41 8.14e-27 Plasma plasminogen activator levels; BRCA cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs11809207 0.523 rs2783626 chr1:26501044 C/T cg23602478 chr1:26503979 CNKSR1 -0.23 -8.06 -0.3 3.85e-15 Height; BRCA cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg05896524 chr21:47604654 C21orf56 0.47 9.53 0.35 3.26e-20 Testicular germ cell tumor; BRCA trans rs6600671 1.000 rs4844381 chr1:121184898 C/T cg17023122 chr1:144479586 NA 0.33 7.97 0.3 7.25e-15 Hip geometry; BRCA cis rs2645424 0.666 rs2272767 chr8:11711059 C/T cg21281001 chr8:11725306 CTSB 0.4 8.0 0.3 5.85e-15 Non-alcoholic fatty liver disease histology (other);Non-alcoholic fatty liver disease histology (lobular); BRCA cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg08859206 chr1:53392774 SCP2 -0.39 -8.19 -0.31 1.43e-15 Monocyte count; BRCA trans rs12458462 1.000 rs12458462 chr18:77472436 C/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.45 -8.37 -0.31 3.62e-16 Monocyte count; BRCA cis rs6835098 1.000 rs10027708 chr4:174083116 T/C cg08422745 chr4:174089978 GALNT7 -0.8 -18.39 -0.59 6.03e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg17507749 chr15:85114479 UBE2QP1 0.55 8.93 0.33 4.42e-18 Schizophrenia; BRCA cis rs7524258 0.868 rs4908448 chr1:7269283 A/G cg07173049 chr1:7289937 CAMTA1 -0.37 -9.12 -0.34 9.56e-19 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs367615 0.918 rs17161895 chr5:108855831 T/G cg17395555 chr5:108820864 NA 0.36 9.48 0.35 5.09e-20 Colorectal cancer (SNP x SNP interaction); BRCA cis rs12545109 0.842 rs2670050 chr8:57402914 T/G cg09654669 chr8:57350985 NA -0.38 -7.87 -0.3 1.47e-14 Obesity-related traits; BRCA cis rs9790314 0.871 rs339114 chr3:161109220 C/T cg03342759 chr3:160939853 NMD3 0.63 14.1 0.49 1.66e-39 Morning vs. evening chronotype; BRCA cis rs11105298 0.891 rs10858890 chr12:89907166 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.61 -0.36 1.64e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs694739 1.000 rs499425 chr11:64105929 A/G cg02228329 chr11:64053129 BAD;GPR137 -0.48 -10.28 -0.38 4.77e-23 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg24558204 chr6:135376177 HBS1L 0.59 16.22 0.54 8.81e-50 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs208520 0.874 rs208491 chr6:66928459 C/G cg07460842 chr6:66804631 NA -0.9 -15.72 -0.53 2.51e-47 Exhaled nitric oxide output; BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg22963979 chr7:1858916 MAD1L1 -0.47 -9.46 -0.35 5.78e-20 Bipolar disorder and schizophrenia; BRCA cis rs10193935 0.901 rs13429697 chr2:42529818 C/T cg27598129 chr2:42591480 NA -0.95 -14.96 -0.51 1.33e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs2882667 0.690 rs825677 chr5:138104770 T/C cg04439458 chr5:138467593 SIL1 0.34 8.47 0.32 1.74e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.16 0.31 1.82e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg21017887 chr14:105400489 NA 0.65 17.16 0.56 1.41e-54 Rheumatoid arthritis; BRCA cis rs9457247 0.624 rs17524252 chr6:167466978 T/G cg07741184 chr6:167504864 NA 0.36 10.4 0.38 1.6e-23 Crohn's disease; BRCA trans rs6582630 0.555 rs10748382 chr12:38504529 C/T cg06521331 chr12:34319734 NA -0.47 -8.88 -0.33 6.98e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs2070488 1.000 rs1841777 chr3:38484819 T/C cg24069376 chr3:38537580 EXOG 0.42 12.07 0.43 2.24e-30 Electrocardiographic conduction measures; BRCA cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg02574844 chr11:5959923 NA -0.43 -8.48 -0.32 1.58e-16 DNA methylation (variation); BRCA cis rs17253792 0.822 rs76555508 chr14:56071868 A/G cg01858014 chr14:56050164 KTN1 -0.78 -11.08 -0.4 3.12e-26 Putamen volume; BRCA cis rs9467773 0.620 rs1490488 chr6:26614808 T/C cg11502198 chr6:26597334 ABT1 0.57 12.14 0.43 1.21e-30 Intelligence (multi-trait analysis); BRCA cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs6665290 0.935 rs11588904 chr1:227196211 T/C cg10327440 chr1:227177885 CDC42BPA -1.15 -48.94 -0.89 2.43e-218 Myeloid white cell count; BRCA cis rs7592578 0.771 rs10432434 chr2:191387079 T/G cg11845111 chr2:191398756 TMEM194B -0.79 -15.17 -0.51 1.28e-44 Diastolic blood pressure; BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg22920501 chr2:26401640 FAM59B -0.61 -10.7 -0.39 1.04e-24 Gut microbiome composition (summer); BRCA cis rs13095912 1.000 rs10937226 chr3:185302885 G/A cg11274856 chr3:185301563 NA 0.35 8.76 0.33 1.71e-17 Systolic blood pressure; BRCA cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg15212455 chr7:39170539 POU6F2 0.43 9.59 0.35 1.87e-20 IgG glycosylation; BRCA cis rs6835098 0.887 rs12644699 chr4:174142874 A/G cg08422745 chr4:174089978 GALNT7 0.71 13.03 0.46 1.45e-34 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg08470875 chr2:26401718 FAM59B -0.54 -8.24 -0.31 9.97e-16 Gut microbiome composition (summer); BRCA cis rs9790314 0.875 rs336568 chr3:161072763 G/C cg04691961 chr3:161091175 C3orf57 -0.58 -15.09 -0.51 3.29e-44 Morning vs. evening chronotype; BRCA trans rs17685 0.632 rs1859793 chr7:75821283 G/A cg19862616 chr7:65841803 NCRNA00174 0.77 23.53 0.68 1.2e-88 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs73086581 1.000 rs6052196 chr20:3945824 T/C cg02187196 chr20:3869020 PANK2 0.51 9.28 0.34 2.51e-19 Response to antidepressants in depression; BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg26314531 chr2:26401878 FAM59B -0.66 -11.29 -0.41 4.42e-27 Gut microbiome composition (summer); BRCA trans rs11098499 0.618 rs28491261 chr4:120294900 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.94 0.3 9.3e-15 Corneal astigmatism; BRCA cis rs758324 0.947 rs72793242 chr5:131242506 A/T cg06307176 chr5:131281290 NA -0.53 -10.34 -0.38 2.79e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7020830 0.858 rs1492714 chr9:37141259 T/C cg14294708 chr9:37120828 ZCCHC7 1.18 42.51 0.86 1.97e-188 Schizophrenia; BRCA cis rs67460515 0.563 rs16831886 chr3:160799830 A/C cg03342759 chr3:160939853 NMD3 -0.69 -13.47 -0.47 1.4e-36 Parkinson's disease; BRCA cis rs7246657 0.882 rs6508719 chr19:37877419 A/G cg14683738 chr19:37701593 ZNF585B 0.46 8.12 0.31 2.48e-15 Coronary artery calcification; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.44 -0.32 2.09e-16 Total body bone mineral density; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg13397359 chr6:42928475 GNMT 0.68 16.37 0.54 1.42e-50 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6496044 0.568 rs1982743 chr15:86068759 A/T cg10818794 chr15:86012489 AKAP13 -0.29 -8.05 -0.3 4.19e-15 Interstitial lung disease; BRCA cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg06636001 chr8:8085503 FLJ10661 -0.42 -9.11 -0.34 1.03e-18 Joint mobility (Beighton score); BRCA cis rs7124681 0.565 rs2904127 chr11:47817290 A/G cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs7246967 0.604 rs58653025 chr19:22941617 T/C cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.54 0.57 1.68e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg06484146 chr7:12443880 VWDE -0.75 -10.82 -0.39 3.54e-25 Coronary artery disease; BRCA cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.15 -0.34 7.46e-19 Electroencephalogram traits; BRCA cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg26384229 chr12:38710491 ALG10B -0.55 -13.56 -0.47 5.62e-37 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs2088217 chr8:58113124 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.89 -0.33 6.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs9329289 0.510 rs35854428 chr10:2554280 T/C cg15501526 chr10:2543763 NA 0.42 9.82 0.36 2.64e-21 Age-related hearing impairment; BRCA cis rs9640161 0.711 rs60268791 chr7:150023800 G/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.54 -13.69 -0.48 1.38e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs11971779 0.648 rs66463279 chr7:139118661 A/G cg07862535 chr7:139043722 LUC7L2 0.39 10.38 0.38 2.02e-23 Diisocyanate-induced asthma; BRCA trans rs7829975 0.714 rs11784052 chr8:8671962 C/T cg16141378 chr3:129829833 LOC729375 -0.33 -8.3 -0.31 6.01e-16 Mood instability; BRCA cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg05665937 chr4:1216051 CTBP1 0.42 8.22 0.31 1.12e-15 Obesity-related traits; BRCA cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg12193833 chr17:30244370 NA -0.61 -10.08 -0.37 2.9e-22 Hip circumference adjusted for BMI; BRCA trans rs12310956 0.532 rs10844707 chr12:33936089 T/C cg26384229 chr12:38710491 ALG10B 0.67 14.13 0.49 1.25e-39 Morning vs. evening chronotype; BRCA trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg15556689 chr8:8085844 FLJ10661 -0.34 -8.76 -0.33 1.73e-17 Triglycerides; BRCA cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg14019146 chr3:50243930 SLC38A3 -0.45 -10.94 -0.4 1.24e-25 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.510 rs3768615 chr1:183103604 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.53 0.57 1.71e-56 Fuchs's corneal dystrophy; BRCA cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 13.75 0.48 7.49e-38 Personality dimensions; BRCA cis rs9814567 0.964 rs9820150 chr3:134223011 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.53 -0.61 5.8e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg12000995 chr2:27665139 KRTCAP3 -0.31 -7.81 -0.3 2.35e-14 Total body bone mineral density; BRCA cis rs7520050 0.933 rs6694340 chr1:46289416 C/T cg24296786 chr1:45957014 TESK2 0.41 9.34 0.35 1.55e-19 Red blood cell count;Reticulocyte count; BRCA cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg05283184 chr6:79620031 NA -0.42 -10.82 -0.39 3.57e-25 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg18876405 chr7:65276391 NA -0.51 -11.65 -0.42 1.36e-28 Aortic root size; BRCA cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg02297831 chr4:17616191 MED28 0.37 8.61 0.32 5.47e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6964587 0.692 rs10271430 chr7:91710466 G/C cg17063962 chr7:91808500 NA 0.55 12.6 0.45 1.13e-32 Breast cancer; BRCA cis rs13394619 0.744 rs10929759 chr2:11722012 C/G cg07314298 chr2:11723111 GREB1 0.56 13.31 0.47 7.12e-36 Endometriosis; BRCA cis rs6878727 0.850 rs12658088 chr5:123719448 T/C cg01806427 chr5:123737813 NA 0.41 9.52 0.35 3.36e-20 Breast cancer; BRCA cis rs1682361 1 rs1682361 chr3:136734014 G/C cg12473912 chr3:136751656 NA 0.51 12.1 0.43 1.74e-30 Schizophrenia; BRCA cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg06022373 chr22:39101656 GTPBP1 -0.62 -15.23 -0.52 6.37e-45 Menopause (age at onset); BRCA cis rs858239 0.806 rs10268610 chr7:23274764 A/G cg23682824 chr7:23144976 KLHL7 0.36 9.06 0.34 1.62e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs4803468 1.000 rs2241708 chr19:41912270 C/T cg09537434 chr19:41945824 ATP5SL -1.01 -25.27 -0.71 3.37e-98 Height; BRCA cis rs1499972 0.941 rs2860308 chr3:117690309 T/G cg07612923 chr3:117604196 NA -0.6 -8.14 -0.31 2.14e-15 Schizophrenia; BRCA trans rs561341 0.941 rs550213 chr17:30317518 C/G cg20587970 chr11:113659929 NA -0.96 -18.65 -0.59 2.81e-62 Hip circumference adjusted for BMI; BRCA cis rs921968 0.565 rs35189512 chr2:219628759 T/C cg02176678 chr2:219576539 TTLL4 -0.42 -11.2 -0.41 1e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08109568 chr15:31115862 NA -0.42 -10.33 -0.38 3.13e-23 Huntington's disease progression; BRCA cis rs8141529 1.000 rs8141529 chr22:29269692 A/G cg02153584 chr22:29168773 CCDC117 0.52 10.8 0.39 4.39e-25 Lymphocyte counts; BRCA cis rs2839186 0.565 rs2839183 chr21:47687144 G/A cg12379764 chr21:47803548 PCNT 0.58 13.39 0.47 3.15e-36 Testicular germ cell tumor; BRCA cis rs17270561 0.636 rs1575535 chr6:25809909 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 9.2 0.34 4.91e-19 Iron status biomarkers; BRCA cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.59 -0.32 6.57e-17 Monocyte percentage of white cells; BRCA cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg17892150 chr10:133769511 PPP2R2D -0.73 -15.75 -0.53 1.83e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs782590 0.967 rs4672054 chr2:55773093 C/A cg18811423 chr2:55921094 PNPT1 0.72 23.04 0.67 5.41e-86 Metabolic syndrome; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg04025307 chr7:1156635 C7orf50 0.59 9.36 0.35 1.38e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg11266682 chr4:10021025 SLC2A9 0.45 11.98 0.43 5.43e-30 Bone mineral density; BRCA cis rs12950390 1.000 rs8068453 chr17:45852354 A/G cg03474202 chr17:45855739 NA 0.42 9.86 0.36 1.94e-21 IgG glycosylation; BRCA cis rs34779708 0.966 rs12257770 chr10:35517234 A/G cg03585969 chr10:35415529 CREM 0.45 9.47 0.35 5.2e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg14356550 chr1:18808102 KLHDC7A -0.5 -11.81 -0.42 3e-29 Breast cancer; BRCA trans rs1941687 0.527 rs1493914 chr18:31362327 C/T cg15819921 chr19:927150 ARID3A -0.51 -9.72 -0.36 6.6e-21 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs1401999 1.000 rs869417 chr3:183689138 T/C cg20387954 chr3:183756860 HTR3D 0.45 10.19 0.37 1.04e-22 Anterior chamber depth; BRCA cis rs1348850 0.914 rs9789582 chr2:178330173 C/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.92 0.37 1.18e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg21545522 chr1:205238299 TMCC2 0.4 8.3 0.31 6.2e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs7927771 0.826 rs7925389 chr11:47466790 A/T cg20307385 chr11:47447363 PSMC3 -0.42 -8.93 -0.33 4.38e-18 Subjective well-being; BRCA cis rs3820928 0.839 rs12151848 chr2:227859326 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.3 -0.31 6e-16 Pulmonary function; BRCA cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg07537917 chr2:241836409 C2orf54 -0.55 -13.81 -0.48 3.78e-38 Urinary metabolites; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg23708337 chr7:1209742 NA 0.51 8.73 0.33 2.26e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2018683 0.707 rs4719961 chr7:28969513 C/T cg19402173 chr7:128379420 CALU -0.44 -10.5 -0.38 6.62e-24 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26314531 chr2:26401878 FAM59B -0.66 -11.25 -0.41 6.5e-27 Gut microbiome composition (summer); BRCA trans rs877282 0.898 rs12356709 chr10:763365 A/G cg22713356 chr15:30763199 NA 1.31 24.8 0.7 1.26e-95 Uric acid levels; BRCA cis rs780094 0.544 rs780110 chr2:27685388 G/A cg22903471 chr2:27725779 GCKR -0.36 -8.65 -0.32 4e-17 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.59 9.31 0.35 2.05e-19 Renal function-related traits (BUN); BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg14820908 chr5:178986412 RUFY1 0.46 11.99 0.43 5.14e-30 Lung cancer; BRCA cis rs6582630 0.555 rs11182422 chr12:38522833 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.03e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs4975616 0.773 rs10078017 chr5:1314009 C/T cg26373071 chr5:1325741 CLPTM1L -0.44 -10.27 -0.38 5.38e-23 Lung cancer; BRCA cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg14530993 chr4:882597 GAK 0.51 8.72 0.33 2.44e-17 Parkinson's disease; BRCA cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg25801113 chr15:45476975 SHF 0.31 7.83 0.3 2e-14 Uric acid levels; BRCA cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs597539 0.552 rs10896384 chr11:68720011 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.72 -16.56 -0.55 1.54e-51 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs796364 1.000 rs281774 chr2:200814572 C/T cg23649088 chr2:200775458 C2orf69 0.58 8.56 0.32 8.56e-17 Schizophrenia; BRCA cis rs9486719 1.000 rs12529248 chr6:96895377 T/G cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.39e-16 Colorectal cancer; BRCA cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg14019146 chr3:50243930 SLC38A3 0.43 10.41 0.38 1.54e-23 Body mass index; BRCA cis rs7715811 1.000 rs6554814 chr5:13774231 T/A cg07548982 chr5:13769939 DNAH5 -0.4 -9.03 -0.34 2.02e-18 Subclinical atherosclerosis traits (other); BRCA cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg12219531 chr12:120966889 COQ5 0.54 11.19 0.4 1.16e-26 High light scatter reticulocyte count; BRCA cis rs6893300 0.785 rs17617710 chr5:179206107 G/A cg14593053 chr5:179126677 CANX -0.36 -8.02 -0.3 4.9e-15 Resting heart rate; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg11062466 chr8:58055876 NA 0.52 8.74 0.33 2.01e-17 Developmental language disorder (linguistic errors); BRCA cis rs12612619 0.732 rs1866655 chr2:27208867 A/T cg00617064 chr2:27272375 NA 0.3 7.83 0.3 1.99e-14 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg05985134 chr18:33552581 C18orf21 0.67 12.83 0.45 1.1e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg14926445 chr8:58193284 C8orf71 -0.46 -8.83 -0.33 1.01e-17 Developmental language disorder (linguistic errors); BRCA cis rs6430549 0.518 rs41521049 chr2:135693069 G/A cg15893373 chr2:135677154 CCNT2 -0.29 -7.85 -0.3 1.78e-14 Hematocrit; BRCA cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg02659138 chr7:134003124 SLC35B4 0.4 11.65 0.42 1.45e-28 Mean platelet volume; BRCA trans rs783540 0.967 rs783526 chr15:83285795 C/A cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.36 -0.31 4.05e-16 Schizophrenia; BRCA cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg01579765 chr21:45077557 HSF2BP -0.43 -11.6 -0.42 2.3e-28 Mean corpuscular volume; BRCA cis rs11971779 0.715 rs11772771 chr7:139058803 T/C cg07862535 chr7:139043722 LUC7L2 0.4 10.97 0.4 9e-26 Diisocyanate-induced asthma; BRCA cis rs6840360 0.530 rs6839802 chr4:152485834 G/A cg22705602 chr4:152727874 NA -0.31 -8.06 -0.3 3.68e-15 Intelligence (multi-trait analysis); BRCA cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs265548 0.538 rs36688 chr19:17911212 A/C cg04517722 chr19:17905589 B3GNT3 0.43 8.46 0.32 1.85e-16 Tumor biomarkers; BRCA cis rs36051895 0.695 rs10815147 chr9:5016145 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.33 -0.31 4.8e-16 Pediatric autoimmune diseases; BRCA cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg01579765 chr21:45077557 HSF2BP -0.45 -12.77 -0.45 2.01e-33 Mean corpuscular volume; BRCA cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg24450063 chr1:156163899 SLC25A44 0.93 18.27 0.59 2.48e-60 Testicular germ cell tumor; BRCA trans rs11098499 0.863 rs10019674 chr4:120443489 C/T cg25214090 chr10:38739885 LOC399744 -0.53 -11.23 -0.41 7.74e-27 Corneal astigmatism; BRCA trans rs66887589 0.616 rs6822808 chr4:120217365 C/A cg25214090 chr10:38739885 LOC399744 0.36 8.37 0.31 3.73e-16 Diastolic blood pressure; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg20007245 chr22:24372913 LOC391322 -0.8 -19.94 -0.62 3.72e-69 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg23711669 chr6:146136114 FBXO30 -0.75 -17.43 -0.57 5.61e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg24229701 chr12:130821962 PIWIL1 0.39 8.89 0.33 6.08e-18 Menopause (age at onset); BRCA cis rs26949 0.511 rs1562235 chr5:59877538 T/G cg02684056 chr5:59996105 DEPDC1B 0.4 9.57 0.35 2.34e-20 Intelligence (multi-trait analysis); BRCA cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg23719950 chr11:63933701 MACROD1 -0.58 -9.62 -0.36 1.48e-20 Mean platelet volume; BRCA cis rs7264396 0.563 rs6060567 chr20:34288250 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.12 -0.43 1.38e-30 Total cholesterol levels; BRCA cis rs561341 1.000 rs497479 chr17:30328605 C/T cg12193833 chr17:30244370 NA -0.55 -8.62 -0.32 5.43e-17 Hip circumference adjusted for BMI; BRCA cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs17270561 0.609 rs9393655 chr6:25711338 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.81 0.33 1.2e-17 Iron status biomarkers; BRCA cis rs2279817 0.863 rs12749985 chr1:18026004 C/T cg21791023 chr1:18019539 ARHGEF10L -0.49 -15.59 -0.52 1.13e-46 Neuroticism; BRCA cis rs6120849 0.754 rs8501 chr20:33590584 T/C cg24642439 chr20:33292090 TP53INP2 0.58 10.12 0.37 1.91e-22 Protein C levels; BRCA cis rs7590720 0.531 rs6435932 chr2:216906030 T/C cg12620499 chr2:216877984 MREG 0.51 12.56 0.44 1.72e-32 Alcohol dependence; BRCA cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg16586182 chr3:47516702 SCAP 0.53 11.54 0.42 3.94e-28 Colorectal cancer; BRCA cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg00321850 chr1:175162397 KIAA0040 0.43 12.3 0.44 2.24e-31 Alcohol dependence; BRCA cis rs9290065 0.622 rs11705811 chr3:160643787 C/T cg03342759 chr3:160939853 NMD3 -0.38 -7.97 -0.3 7.16e-15 Kawasaki disease; BRCA cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg20203395 chr5:56204925 C5orf35 0.38 8.67 0.32 3.6e-17 Initial pursuit acceleration; BRCA cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03644281 chr6:41068752 NFYA;LOC221442 0.38 7.82 0.3 2.19e-14 Alzheimer's disease (late onset); BRCA cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg03684893 chr10:554711 DIP2C 0.39 9.14 0.34 8.08e-19 Psychosis in Alzheimer's disease; BRCA cis rs7903847 0.642 rs10882914 chr10:99142057 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg13298116 chr11:62369859 EML3;MTA2 0.58 13.44 0.47 1.88e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2625529 0.590 rs12442886 chr15:72473611 T/C cg16672083 chr15:72433130 SENP8 0.67 15.2 0.52 9e-45 Red blood cell count; BRCA cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg09165964 chr15:75287851 SCAMP5 -0.85 -20.27 -0.63 6.12e-71 Blood trace element (Zn levels); BRCA cis rs2197308 0.619 rs4002730 chr12:37876400 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.04 0.56 6.16e-54 Morning vs. evening chronotype; BRCA cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg27398817 chr8:82754497 SNX16 -0.35 -8.05 -0.3 4.1e-15 Diastolic blood pressure; BRCA cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg02527881 chr3:46936655 PTH1R -0.36 -8.35 -0.31 4.17e-16 Birth weight; BRCA cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg06115741 chr20:33292138 TP53INP2 -0.37 -8.15 -0.31 1.9e-15 Glomerular filtration rate (creatinine); BRCA cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg11901034 chr3:128598214 ACAD9 -0.36 -8.83 -0.33 9.67e-18 IgG glycosylation; BRCA cis rs698833 0.501 rs35347977 chr2:44506921 C/T cg04920474 chr2:44395004 PPM1B 0.38 8.89 0.33 5.99e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs360798 0.512 rs2710640 chr2:63144305 A/G cg17519650 chr2:63277830 OTX1 0.37 8.28 0.31 7.2e-16 Coronary artery disease; BRCA cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg24549020 chr5:56110836 MAP3K1 0.52 10.66 0.39 1.55e-24 Type 2 diabetes; BRCA cis rs911119 1.000 rs34374560 chr20:23609462 C/T cg16589663 chr20:23618590 CST3 0.45 8.5 0.32 1.35e-16 Chronic kidney disease; BRCA cis rs11229555 0.645 rs11229549 chr11:58395914 T/C cg15696309 chr11:58395628 NA -0.49 -9.65 -0.36 1.15e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg12591125 chr7:1885375 MAD1L1 -0.48 -8.67 -0.32 3.42e-17 Bipolar disorder; BRCA cis rs4321325 0.546 rs11886766 chr2:127948621 G/A cg11380483 chr2:127933992 NA 0.43 8.81 0.33 1.14e-17 Protein C levels; BRCA cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.67 14.68 0.5 2.88e-42 Chronic sinus infection; BRCA cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg09640425 chr7:158790006 NA -0.37 -7.89 -0.3 1.35e-14 Facial morphology (factor 20); BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.77 0.36 4.08e-21 Mean corpuscular hemoglobin; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg08888203 chr3:10149979 C3orf24 0.67 14.48 0.5 2.56e-41 Alzheimer's disease; BRCA cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg23711669 chr6:146136114 FBXO30 0.79 18.99 0.6 4.44e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg22491629 chr6:157744540 C6orf35 -0.65 -11.64 -0.42 1.62e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg02659138 chr7:134003124 SLC35B4 0.34 10.72 0.39 9.27e-25 Mean platelet volume; BRCA cis rs72634258 0.554 rs12745962 chr1:7919825 C/T cg26816564 chr1:7831052 VAMP3 0.54 10.53 0.38 5.3e-24 Inflammatory bowel disease; BRCA cis rs7666738 0.606 rs10006454 chr4:99080361 G/A cg05340658 chr4:99064831 C4orf37 0.49 10.82 0.39 3.73e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg18876405 chr7:65276391 NA 0.44 8.6 0.32 6.13e-17 Corneal structure; BRCA cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22455342 chr2:225449267 CUL3 0.68 16.82 0.55 7.71e-53 IgE levels in asthmatics (D.p. specific); BRCA cis rs7809950 0.954 rs2520245 chr7:107137428 G/C cg23024343 chr7:107201750 COG5 -0.42 -9.55 -0.35 2.73e-20 Coronary artery disease; BRCA cis rs887829 0.694 rs6749496 chr2:234624286 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -9.63 -0.36 1.4e-20 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg14582100 chr15:45693742 SPATA5L1 0.38 11.8 0.42 3.22e-29 Homoarginine levels; BRCA cis rs738322 1.000 rs4379 chr22:38569171 T/C cg25457927 chr22:38595422 NA -0.31 -11.81 -0.42 3.02e-29 Cutaneous nevi; BRCA cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg11663144 chr21:46675770 NA -0.6 -13.81 -0.48 3.58e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4664304 0.620 rs10929956 chr2:160714615 C/T cg18514922 chr2:160761262 LY75 0.34 7.97 0.3 7.35e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs10752881 1.000 rs12126434 chr1:182988414 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.62 -16.51 -0.55 2.75e-51 Colorectal cancer; BRCA cis rs4285028 0.747 rs1463736 chr3:121400725 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.85 -0.48 2.53e-38 Multiple sclerosis; BRCA cis rs7927771 0.524 rs754434 chr11:47814280 A/G cg20307385 chr11:47447363 PSMC3 0.41 9.34 0.35 1.54e-19 Subjective well-being; BRCA cis rs4919694 0.901 rs113541728 chr10:104716771 A/T cg04362960 chr10:104952993 NT5C2 0.97 15.09 0.51 3.25e-44 Arsenic metabolism; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.37e-15 Total body bone mineral density; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -8.88 -0.33 6.98e-18 Longevity;Endometriosis; BRCA cis rs1355223 0.583 rs2941060 chr11:34879154 G/A cg11058730 chr11:34937778 PDHX;APIP 0.68 16.03 0.54 7.64e-49 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg18904891 chr8:8559673 CLDN23 0.64 12.57 0.45 1.54e-32 Obesity-related traits; BRCA trans rs629535 0.814 rs506931 chr8:70068129 T/G cg21567404 chr3:27674614 NA 1.01 20.74 0.63 1.84e-73 Dupuytren's disease; BRCA cis rs9814567 0.806 rs4955526 chr3:134317337 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.34 -7.96 -0.3 7.65e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs870825 0.616 rs10022834 chr4:185649431 A/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg10932868 chr11:921992 NA 0.49 12.53 0.44 2.39e-32 Alzheimer's disease (late onset); BRCA cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg06145435 chr7:1022769 CYP2W1 0.5 9.25 0.34 3.29e-19 Bronchopulmonary dysplasia; BRCA cis rs6964587 0.869 rs10241720 chr7:91527367 G/T cg17063962 chr7:91808500 NA -0.51 -11.82 -0.42 2.74e-29 Breast cancer; BRCA cis rs11204677 1 rs11204677 chr1:150574695 C/G cg18016565 chr1:150552671 MCL1 -0.45 -9.97 -0.37 7.34e-22 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs9467773 0.620 rs2494692 chr6:26615223 G/A cg11502198 chr6:26597334 ABT1 0.57 12.14 0.43 1.21e-30 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg13902645 chr11:5959945 NA -0.55 -11.1 -0.4 2.73e-26 DNA methylation (variation); BRCA cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg01475377 chr6:109611718 NA -0.59 -16.37 -0.54 1.4e-50 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.647 rs11633869 chr15:77133322 G/T cg23625390 chr15:77176239 SCAPER 0.55 13.96 0.48 7.5e-39 Blood metabolite levels; BRCA cis rs9837602 1.000 rs10049383 chr3:99748548 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.22 0.41 8.3e-27 Breast cancer; BRCA cis rs1348850 0.519 rs1527407 chr2:178525630 T/G cg22681709 chr2:178499509 PDE11A -0.38 -8.22 -0.31 1.15e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9435341 0.965 rs1730859 chr1:107617707 A/G cg09367891 chr1:107599246 PRMT6 0.56 10.32 0.38 3.37e-23 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.55 -0.32 8.9e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs72848980 0.512 rs3781362 chr10:105375601 T/C cg00126946 chr10:105363258 SH3PXD2A 0.45 8.76 0.33 1.72e-17 White matter hyperintensity burden; BRCA cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg11812906 chr14:75593930 NEK9 0.68 15.27 0.52 4.2e-45 Height; BRCA cis rs208520 0.690 rs207102 chr6:66795671 G/A cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs6430585 0.759 rs12467770 chr2:136536095 G/A cg07169764 chr2:136633963 MCM6 1.23 26.55 0.72 2.93e-105 Corneal structure; BRCA cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 9.32 0.35 1.83e-19 Personality dimensions; BRCA trans rs66887589 0.934 rs7672519 chr4:120544112 C/T cg25214090 chr10:38739885 LOC399744 -0.34 -7.85 -0.3 1.72e-14 Diastolic blood pressure; BRCA cis rs10465746 0.935 rs35946036 chr1:84438991 A/G cg10977910 chr1:84465055 TTLL7 0.51 10.36 0.38 2.4e-23 Obesity-related traits; BRCA cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg17747265 chr1:1875780 NA -0.46 -13.24 -0.46 1.5e-35 Body mass index; BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg09509183 chr1:209979624 IRF6 0.34 8.21 0.31 1.25e-15 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12756686 chr19:29218302 NA 0.57 11.02 0.4 5.79e-26 Methadone dose in opioid dependence; BRCA cis rs7098414 0.530 rs10749572 chr10:82136664 G/T cg00277334 chr10:82204260 NA -0.45 -9.52 -0.35 3.44e-20 Post bronchodilator FEV1; BRCA cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg25554036 chr4:6271136 WFS1 0.42 9.8 0.36 3.2e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2404602 0.647 rs907594 chr15:77197745 C/A cg23625390 chr15:77176239 SCAPER -0.55 -13.79 -0.48 4.74e-38 Blood metabolite levels; BRCA cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg01475377 chr6:109611718 NA -0.6 -16.77 -0.55 1.45e-52 Reticulocyte fraction of red cells; BRCA cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.42 -12.28 -0.44 2.79e-31 Monocyte percentage of white cells; BRCA cis rs6594713 0.717 rs13436825 chr5:112817687 T/A cg12552261 chr5:112820674 MCC 0.49 8.47 0.32 1.64e-16 Brain cytoarchitecture; BRCA cis rs11764590 0.694 rs6461115 chr7:2103668 A/G cg02951883 chr7:2050386 MAD1L1 0.39 8.47 0.32 1.71e-16 Neuroticism; BRCA cis rs7580658 0.963 rs12622436 chr2:128081682 C/A cg09760422 chr2:128146352 NA -0.35 -7.88 -0.3 1.38e-14 Protein C levels; BRCA cis rs763121 0.853 rs138702 chr22:39132601 A/T cg14440974 chr22:39074834 NA 0.35 8.11 0.31 2.65e-15 Menopause (age at onset); BRCA cis rs2243480 1.000 rs2533288 chr7:66056711 C/G cg18252515 chr7:66147081 NA -1.05 -15.74 -0.53 2.14e-47 Diabetic kidney disease; BRCA cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg21573476 chr21:45109991 RRP1B -0.37 -9.4 -0.35 9.62e-20 Mean corpuscular volume; BRCA cis rs6963495 0.818 rs73190184 chr7:105163736 C/T cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg24060327 chr5:131705240 SLC22A5 -0.64 -12.41 -0.44 7.93e-32 Breast cancer; BRCA trans rs1005277 0.522 rs289643 chr10:37941494 T/G cg17830980 chr10:43048298 ZNF37B -0.41 -9.4 -0.35 9.41e-20 Extrinsic epigenetic age acceleration; BRCA cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.62 0.42 1.82e-28 Height; BRCA cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.34 -9.85 -0.36 2.18e-21 Intelligence (multi-trait analysis); BRCA cis rs611744 0.647 rs628206 chr8:109247873 A/G cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs919433 0.713 rs6719483 chr2:198472886 A/G cg00792783 chr2:198669748 PLCL1 0.35 7.9 0.3 1.18e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.05 -0.37 3.53e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs9287719 0.967 rs6755548 chr2:10746126 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg24060327 chr5:131705240 SLC22A5 -0.46 -9.15 -0.34 7.57e-19 Acylcarnitine levels; BRCA cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg18876405 chr7:65276391 NA -0.55 -12.97 -0.46 2.65e-34 Aortic root size; BRCA cis rs7301016 0.846 rs73124315 chr12:62970437 C/T cg11441379 chr12:63026424 NA 0.46 8.69 0.32 3.13e-17 IgG glycosylation; BRCA cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg18132916 chr6:79620363 NA -0.48 -10.94 -0.4 1.21e-25 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg11663144 chr21:46675770 NA -0.6 -13.87 -0.48 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1003719 0.788 rs2835579 chr21:38457965 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.18 0.49 7.11e-40 Eye color traits; BRCA cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg22153463 chr1:85462885 MCOLN2 -0.57 -10.21 -0.37 9.06e-23 Serum sulfate level; BRCA cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg21535247 chr6:8435926 SLC35B3 0.42 9.57 0.35 2.35e-20 Motion sickness; BRCA cis rs4478858 0.735 rs4949205 chr1:31800579 A/G cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs6840258 1.000 rs72667765 chr4:87965942 G/A cg08197287 chr4:87952173 AFF1 -0.45 -8.95 -0.33 3.78e-18 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg04025307 chr7:1156635 C7orf50 0.44 9.78 0.36 3.7e-21 Bronchopulmonary dysplasia; BRCA trans rs61931739 0.534 rs2636072 chr12:34062386 C/T cg26384229 chr12:38710491 ALG10B 0.53 11.32 0.41 3.38e-27 Morning vs. evening chronotype; BRCA cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg15997130 chr1:24165203 NA -0.45 -11.33 -0.41 3.15e-27 Immature fraction of reticulocytes; BRCA cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg05868516 chr6:26286170 HIST1H4H 0.45 9.95 0.37 8.61e-22 Educational attainment; BRCA cis rs1448094 0.512 rs11832503 chr12:86240797 A/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.22 -0.34 4.11e-19 Major depressive disorder; BRCA cis rs11098499 0.863 rs2306456 chr4:120472422 C/G cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs6500602 0.964 rs2304633 chr16:4496973 T/A cg08645402 chr16:4508243 NA 0.4 9.28 0.34 2.65e-19 Schizophrenia; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg09256448 chr16:638327 NA 0.32 8.6 0.32 6.25e-17 Height; BRCA cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.24 -0.41 7.07e-27 Schizophrenia; BRCA cis rs7809950 0.954 rs11977187 chr7:107210383 C/T cg23024343 chr7:107201750 COG5 0.39 8.5 0.32 1.38e-16 Coronary artery disease; BRCA cis rs2016266 0.785 rs10747660 chr12:53649874 C/G cg26875137 chr12:53738046 NA 0.31 8.09 0.3 2.91e-15 Bone mineral density (spine);Bone mineral density; BRCA cis rs3858526 0.584 rs10769276 chr11:5868020 G/T cg25319279 chr11:5960081 NA -0.38 -8.11 -0.31 2.6e-15 DNA methylation (variation); BRCA cis rs10845606 1.000 rs11055013 chr12:12829037 T/C cg09462578 chr12:12878428 APOLD1 -0.61 -10.85 -0.39 2.84e-25 Systemic lupus erythematosus; BRCA cis rs6448317 0.954 rs7666033 chr4:24925272 A/G cg21108841 chr4:24914750 CCDC149 -0.39 -8.65 -0.32 4.21e-17 Heschl's gyrus morphology; BRCA trans rs4714291 0.832 rs2984431 chr6:39980900 T/A cg02267698 chr19:7991119 CTXN1 -0.43 -8.79 -0.33 1.34e-17 Strep throat; BRCA cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg14255062 chr9:123606675 PSMD5;LOC253039 0.32 8.5 0.32 1.38e-16 Birth weight; BRCA cis rs939658 1.000 rs8033963 chr15:79455350 C/T cg17916960 chr15:79447300 NA 0.38 9.76 0.36 4.44e-21 Refractive error; BRCA cis rs3806843 0.676 rs2245643 chr5:140029780 C/T cg16179182 chr5:140090404 VTRNA1-1 0.45 10.36 0.38 2.27e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs7666738 0.830 rs10007261 chr4:98926155 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg03146154 chr1:46216737 IPP -0.5 -10.92 -0.4 1.47e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg22907277 chr7:1156413 C7orf50 0.55 8.87 0.33 7.42e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs853679 0.546 rs2232429 chr6:28359632 T/G cg06606381 chr12:133084897 FBRSL1 -0.9 -8.84 -0.33 9.38e-18 Depression; BRCA cis rs10046574 0.634 rs10266715 chr7:135155366 C/T cg27474649 chr7:135195673 CNOT4 -0.53 -8.15 -0.31 1.92e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7512552 0.839 rs834231 chr1:150389392 A/T cg15654264 chr1:150340011 RPRD2 -0.37 -8.19 -0.31 1.44e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs9487051 0.646 rs55677234 chr6:109621974 G/A cg01475377 chr6:109611718 NA -0.4 -8.73 -0.33 2.27e-17 Reticulocyte fraction of red cells; BRCA trans rs11098499 0.866 rs9991221 chr4:120292107 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs7524258 0.835 rs2412150 chr1:7303343 A/C cg07173049 chr1:7289937 CAMTA1 0.54 13.02 0.46 1.57e-34 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg07755735 chr2:20870362 GDF7 0.32 8.33 0.31 5.08e-16 Abdominal aortic aneurysm; BRCA cis rs3820928 0.874 rs4675138 chr2:227884118 G/A cg11843606 chr2:227700838 RHBDD1 -0.37 -8.23 -0.31 1.03e-15 Pulmonary function; BRCA cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.8e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1371867 0.846 rs1660329 chr8:101304048 G/T cg06636551 chr8:101224915 SPAG1 -0.38 -8.72 -0.33 2.39e-17 Atrioventricular conduction; BRCA cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg21385522 chr1:16154831 NA 0.54 10.01 0.37 5.17e-22 Dilated cardiomyopathy; BRCA cis rs311392 0.902 rs419813 chr8:55092385 A/T cg11783602 chr8:55087084 NA -0.31 -9.07 -0.34 1.49e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs2243480 1.000 rs1499613 chr7:65730860 G/A cg18252515 chr7:66147081 NA 1.04 15.68 0.53 4.14e-47 Diabetic kidney disease; BRCA cis rs11249608 0.548 rs6601007 chr5:178455796 G/C cg21905437 chr5:178450457 ZNF879 0.51 10.78 0.39 5.29e-25 Pubertal anthropometrics; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg13047869 chr3:10149882 C3orf24 0.58 12.1 0.43 1.7e-30 Alzheimer's disease; BRCA cis rs3760982 0.585 rs68073292 chr19:44291401 T/C cg11993925 chr19:44307056 LYPD5 0.38 8.89 0.33 6e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs10504073 0.584 rs11784268 chr8:49956339 T/G cg00325661 chr8:49890786 NA 0.49 14.07 0.49 2.32e-39 Blood metabolite ratios; BRCA cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg12436631 chr1:155007014 DCST1;DCST2 0.27 8.43 0.32 2.24e-16 Prostate cancer; BRCA cis rs7188861 0.724 rs1794019 chr16:11379775 T/C cg01510278 chr16:11456238 NA 0.42 8.29 0.31 6.46e-16 HDL cholesterol; BRCA cis rs875971 0.545 rs313828 chr7:65552614 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.41 -0.38 1.53e-23 Aortic root size; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg14004847 chr7:1930337 MAD1L1 -0.46 -8.82 -0.33 1.1e-17 Bipolar disorder and schizophrenia; BRCA cis rs911119 1.000 rs1010117 chr20:23608421 G/C cg16589663 chr20:23618590 CST3 0.45 8.56 0.32 8.21e-17 Chronic kidney disease; BRCA cis rs716316 0.590 rs6135309 chr20:14902522 C/T cg04470754 chr20:14904432 MACROD2 -0.36 -8.05 -0.3 4.2e-15 Advanced glycation end-product levels; BRCA cis rs4722585 0.764 rs4259314 chr7:26182214 A/G cg07876897 chr7:26191696 NFE2L3 -0.4 -8.46 -0.32 1.84e-16 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA trans rs1997103 0.954 rs1917769 chr7:55392325 T/A cg20935933 chr6:143382018 AIG1 0.61 11.61 0.42 2.03e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs6951245 0.935 rs61753396 chr7:1105372 A/G cg13565492 chr6:43139072 SRF -0.84 -11.44 -0.41 1.02e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg08219700 chr8:58056026 NA 0.63 10.0 0.37 5.69e-22 Developmental language disorder (linguistic errors); BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg08742575 chr21:47604166 C21orf56 0.41 8.01 0.3 5.51e-15 Testicular germ cell tumor; BRCA cis rs7737355 0.898 rs26007 chr5:131006356 T/A cg06307176 chr5:131281290 NA 0.52 10.24 0.38 6.86e-23 Life satisfaction; BRCA cis rs7975161 0.640 rs4477504 chr12:104710465 T/C cg25273343 chr12:104657179 TXNRD1 -0.49 -9.76 -0.36 4.49e-21 Toenail selenium levels; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg10862848 chr6:42927986 GNMT -0.36 -14.93 -0.51 1.89e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6547741 0.935 rs12615690 chr2:27851120 T/C cg27432699 chr2:27873401 GPN1 0.43 9.0 0.34 2.57e-18 Oral cavity cancer; BRCA cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg06453172 chr10:134556979 INPP5A -0.53 -11.12 -0.4 2.14e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9325144 0.647 rs7487395 chr12:38865660 C/A cg26384229 chr12:38710491 ALG10B -0.5 -12.1 -0.43 1.65e-30 Morning vs. evening chronotype; BRCA cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg13770153 chr20:60521292 NA -0.37 -8.46 -0.32 1.8e-16 Body mass index; BRCA cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg22800045 chr5:56110881 MAP3K1 0.65 12.34 0.44 1.62e-31 Initial pursuit acceleration; BRCA cis rs17345786 0.520 rs1476123 chr3:101313413 C/G cg12386194 chr3:101231763 SENP7 0.43 9.55 0.35 2.73e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg05896524 chr21:47604654 C21orf56 -0.51 -9.92 -0.37 1.18e-21 Testicular germ cell tumor; BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.44 -10.23 -0.38 7.3e-23 Lymphocyte counts; BRCA cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.77e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg10523679 chr1:76189770 ACADM 0.77 15.83 0.53 7.1e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs877282 0.583 rs11253441 chr10:828288 C/T cg15764593 chr10:829463 NA 0.64 10.34 0.38 2.8e-23 Uric acid levels; BRCA trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs6424115 0.546 rs35993651 chr1:24180613 C/G cg15997130 chr1:24165203 NA -0.51 -13.39 -0.47 3.11e-36 Immature fraction of reticulocytes; BRCA trans rs12310956 0.532 rs1906134 chr12:33957135 A/C cg26384229 chr12:38710491 ALG10B 0.66 13.95 0.48 8.57e-39 Morning vs. evening chronotype; BRCA cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg12140854 chr5:148520817 ABLIM3 -0.41 -8.67 -0.32 3.56e-17 Breast cancer; BRCA cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg17724175 chr1:150552817 MCL1 -0.34 -10.88 -0.4 2.05e-25 Blood protein levels; BRCA cis rs2404602 0.735 rs4886493 chr15:76679026 A/G cg23625390 chr15:77176239 SCAPER -0.53 -12.87 -0.45 7.31e-34 Blood metabolite levels; BRCA cis rs7098414 0.511 rs7899545 chr10:82150635 G/C cg01528321 chr10:82214614 TSPAN14 0.67 14.46 0.5 3.38e-41 Post bronchodilator FEV1; BRCA trans rs9291683 0.510 rs4318649 chr4:10016815 T/C cg26043149 chr18:55253948 FECH 0.36 7.81 0.3 2.29e-14 Bone mineral density; BRCA cis rs11098499 0.954 rs9993199 chr4:120392873 A/G cg09307838 chr4:120376055 NA -0.74 -15.9 -0.53 3.32e-48 Corneal astigmatism; BRCA cis rs1800682 0.528 rs11202918 chr10:90742008 A/G cg03111039 chr10:90751583 FAS;ACTA2 0.53 12.52 0.44 2.54e-32 Chronic lymphocytic leukemia; BRCA cis rs9463078 0.809 rs9357469 chr6:45049811 C/T cg25276700 chr6:44698697 NA -0.36 -8.19 -0.31 1.4e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg06766960 chr11:133703094 NA -0.62 -13.29 -0.47 9.43e-36 Childhood ear infection; BRCA cis rs10089 0.552 rs56718459 chr5:127546214 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.59 11.73 0.42 6.7200000000000006e-29 Ileal carcinoids; BRCA cis rs8177253 0.665 rs4525863 chr3:133436136 C/A cg11941060 chr3:133502564 NA -0.35 -8.01 -0.3 5.36e-15 Iron status biomarkers; BRCA cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA trans rs7200543 1.000 rs72774845 chr16:15147954 A/C cg24683922 chr1:11983373 KIAA2013 -0.37 -8.48 -0.32 1.59e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA trans rs2018683 0.707 rs917218 chr7:28975122 A/C cg19402173 chr7:128379420 CALU -0.39 -9.38 -0.35 1.13e-19 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg04518342 chr5:131593106 PDLIM4 0.36 9.03 0.34 1.99e-18 Breast cancer; BRCA cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg08754478 chr10:133766260 PPP2R2D 0.57 11.78 0.42 3.87e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7647973 0.516 rs4955418 chr3:49200627 A/G cg06212747 chr3:49208901 KLHDC8B 0.54 11.82 0.42 2.74e-29 Menarche (age at onset); BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00166722 chr3:10149974 C3orf24 0.67 13.49 0.47 1.13e-36 Alzheimer's disease; BRCA cis rs9296092 0.538 rs3916674 chr6:33522975 C/T cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.6 -13.23 -0.46 1.81e-35 IgG glycosylation; BRCA cis rs11690935 0.686 rs10165126 chr2:172820315 C/T cg13550731 chr2:172543902 DYNC1I2 -0.7 -18.9 -0.6 1.34e-63 Schizophrenia; BRCA cis rs703842 1.000 rs703842 chr12:58162739 C/T cg18357645 chr12:58087776 OS9 0.3 7.87 0.3 1.56e-14 Multiple sclerosis; BRCA cis rs877282 0.583 rs10904564 chr10:819459 C/G cg15764593 chr10:829463 NA -0.65 -10.53 -0.38 5.14e-24 Uric acid levels; BRCA trans rs7618501 0.602 rs10049087 chr3:50123417 A/G cg21659725 chr3:3221576 CRBN -0.5 -12.88 -0.45 6.45e-34 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.65 10.54 0.38 4.62e-24 Renal function-related traits (BUN); BRCA cis rs2885056 0.800 rs8105074 chr19:10708692 A/G cg04833646 chr19:10679720 CDKN2D 0.72 13.42 0.47 2.43e-36 Red cell distribution width; BRCA cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg26384229 chr12:38710491 ALG10B 0.76 17.13 0.56 1.94e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg00012203 chr2:219082015 ARPC2 -0.47 -9.1 -0.34 1.09e-18 Colorectal cancer; BRCA cis rs10193935 0.901 rs2118889 chr2:42451683 G/T cg27598129 chr2:42591480 NA -0.8 -13.48 -0.47 1.3e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs9914988 0.778 rs9907192 chr17:27122426 C/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs672059 1.000 rs544352 chr1:183157546 G/A ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.08e-17 Hypertriglyceridemia; BRCA cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg06238570 chr21:40685208 BRWD1 -0.43 -8.77 -0.33 1.61e-17 Cognitive function; BRCA cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.37 -0.31 3.65e-16 Menarche (age at onset); BRCA cis rs7809950 1.000 rs2520264 chr7:107179344 T/C cg23024343 chr7:107201750 COG5 -0.39 -8.99 -0.33 2.87e-18 Coronary artery disease; BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg04944784 chr2:26401820 FAM59B -0.74 -12.06 -0.43 2.62e-30 Gut microbiome composition (summer); BRCA cis rs10752881 1.000 rs10797811 chr1:182984432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.51 0.55 2.97e-51 Colorectal cancer; BRCA cis rs4803468 0.905 rs284662 chr19:41932275 T/C cg09537434 chr19:41945824 ATP5SL -1.01 -22.91 -0.67 2.9e-85 Height; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg09177884 chr7:1199841 ZFAND2A -0.5 -10.65 -0.39 1.65e-24 Longevity;Endometriosis; BRCA cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.94 -0.33 3.99e-18 Monocyte percentage of white cells; BRCA cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg06784218 chr1:46089804 CCDC17 -0.43 -10.2 -0.37 9.99e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1538970 0.962 rs4660301 chr1:45820149 T/A cg05343316 chr1:45956843 TESK2 0.58 11.74 0.42 5.64e-29 Platelet count; BRCA cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg20607287 chr7:12443886 VWDE -0.56 -7.85 -0.3 1.77e-14 Coronary artery disease; BRCA cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg23583168 chr7:148888333 NA -0.79 -18.98 -0.6 4.88e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2425143 1.000 rs45595739 chr20:34320759 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg03929089 chr4:120376271 NA -0.48 -9.04 -0.34 1.81e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02018176 chr4:1364513 KIAA1530 0.38 7.92 0.3 1.05e-14 Longevity; BRCA cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.56 -0.47 5.53e-37 Developmental language disorder (linguistic errors); BRCA cis rs11711311 0.712 rs3773683 chr3:113341007 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.4 -8.57 -0.32 8.03e-17 IgG glycosylation; BRCA cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg11608241 chr8:8085544 FLJ10661 0.31 8.56 0.32 8.24e-17 Systolic blood pressure; BRCA cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.17 -0.31 1.64e-15 Colorectal cancer; BRCA cis rs910316 0.737 rs175055 chr14:75488946 T/G cg23033748 chr14:75592666 NEK9 -0.34 -8.06 -0.3 3.8e-15 Height; BRCA cis rs72772090 0.710 rs1559085 chr5:96078702 A/G cg24982541 chr5:96078678 CAST -0.46 -8.03 -0.3 4.58e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg06671706 chr8:8559999 CLDN23 0.45 8.59 0.32 6.51e-17 Obesity-related traits; BRCA cis rs10751667 0.600 rs11246377 chr11:999796 G/T cg01483505 chr11:975446 AP2A2 0.33 9.05 0.34 1.66e-18 Alzheimer's disease (late onset); BRCA cis rs2243480 0.803 rs35480979 chr7:65357084 A/G cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg24642439 chr20:33292090 TP53INP2 0.55 11.92 0.43 1.01e-29 Coronary artery disease; BRCA cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg13175981 chr1:150552382 MCL1 0.43 9.54 0.35 2.86e-20 Tonsillectomy; BRCA cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA trans rs2832077 0.527 rs59730679 chr21:30226244 T/C cg14791747 chr16:20752902 THUMPD1 0.45 14.25 0.49 3.24e-40 Cognitive test performance; BRCA cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs514406 0.505 rs269293 chr1:53187767 A/C cg08859206 chr1:53392774 SCP2 -0.43 -8.62 -0.32 5.43e-17 Monocyte count; BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.8 0.33 1.24e-17 Platelet count; BRCA cis rs6684514 1.000 rs12134983 chr1:156290409 T/C cg16558208 chr1:156270281 VHLL 0.36 8.28 0.31 6.96e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs3812049 0.784 rs2617617 chr5:127455008 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.58 10.58 0.39 3.1e-24 Lymphocyte counts;Red cell distribution width; BRCA cis rs7631605 0.905 rs4678943 chr3:37197355 T/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.87 0.36 1.83e-21 Cerebrospinal P-tau181p levels; BRCA cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12756686 chr19:29218302 NA 0.57 10.99 0.4 7.43e-26 Methadone dose in opioid dependence; BRCA cis rs4481887 1.000 rs4372295 chr1:248464871 G/T cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.6e-17 Common traits (Other); BRCA cis rs6772849 0.930 rs7639400 chr3:128323356 T/C cg16766828 chr3:128327626 NA -0.41 -9.06 -0.34 1.6e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs2992756 0.625 rs2992752 chr1:18808526 A/C cg14356550 chr1:18808102 KLHDC7A -0.4 -8.29 -0.31 6.67e-16 Breast cancer; BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg24531977 chr5:56204891 C5orf35 -0.88 -18.18 -0.58 7.95e-60 Initial pursuit acceleration; BRCA cis rs7833986 0.501 rs2953897 chr8:56980569 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.36 0.47 4.56e-36 Height; BRCA cis rs12545109 1.000 rs12545109 chr8:57313906 A/C cg09654669 chr8:57350985 NA -0.41 -9.04 -0.34 1.85e-18 Obesity-related traits; BRCA cis rs1874326 0.545 rs4626544 chr7:138110301 C/G cg18008034 chr7:138118925 NA -0.45 -9.28 -0.34 2.54e-19 Quantitative traits; BRCA cis rs1113500 0.933 rs1419003 chr1:108616955 A/C cg06207961 chr1:108661230 NA 0.45 11.09 0.4 2.99e-26 Growth-regulated protein alpha levels; BRCA cis rs9467773 0.620 rs2504540 chr6:26641626 A/G cg11502198 chr6:26597334 ABT1 0.56 11.95 0.43 7.23e-30 Intelligence (multi-trait analysis); BRCA cis rs4423214 0.798 rs12224205 chr11:71180992 A/G cg05163923 chr11:71159392 DHCR7 -0.58 -11.81 -0.42 2.95e-29 Vitamin D levels; BRCA cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -9.42 -0.35 8.03e-20 Personality dimensions; BRCA trans rs12517041 1.000 rs16892316 chr5:23282819 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.29 -0.31 6.76e-16 Calcium levels; BRCA cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.3 -0.31 6.42e-16 Bipolar disorder; BRCA cis rs4664304 0.620 rs55664214 chr2:160708059 C/T cg01092293 chr2:160761427 LY75 -0.33 -7.95 -0.3 8.65e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs4662945 0.504 rs35568023 chr2:130251812 A/T cg05903289 chr2:130345205 NA -0.32 -8.08 -0.3 3.22e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11644478 chr21:40555479 PSMG1 0.89 21.0 0.64 7.43e-75 Cognitive function; BRCA cis rs4900538 0.855 rs12586378 chr14:102853150 T/C cg18135206 chr14:102964638 TECPR2 -0.91 -21.1 -0.64 2.26e-75 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs589448 0.934 rs554591 chr12:69753847 T/C cg22834771 chr12:69754056 YEATS4 -0.43 -10.64 -0.39 1.85e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg27478167 chr7:817139 HEATR2 -0.48 -9.96 -0.37 7.97e-22 Cerebrospinal P-tau181p levels; BRCA cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7267979 1.000 rs2482943 chr20:25380593 G/A cg08601574 chr20:25228251 PYGB -0.39 -8.93 -0.33 4.57e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg12516959 chr21:47718080 NA 0.33 7.86 0.3 1.59e-14 Testicular germ cell tumor; BRCA cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg06970220 chr1:156163860 SLC25A44 0.39 9.52 0.35 3.51e-20 Testicular germ cell tumor; BRCA cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.57 0.57 1.12e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs8170 0.603 rs10259 chr19:17430915 G/A cg04749549 chr19:17459798 NA -0.37 -9.76 -0.36 4.38e-21 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs12618769 0.625 rs12618524 chr2:99064029 T/A cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg11752832 chr7:134001865 SLC35B4 0.51 13.34 0.47 5.6e-36 Mean platelet volume; BRCA cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.54 0.42 3.99e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs796364 1.000 rs281760 chr2:200787804 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.66 0.42 1.24e-28 Schizophrenia; BRCA cis rs870825 0.616 rs28500698 chr4:185627746 A/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7592578 0.771 rs75579212 chr2:191376575 C/T cg11845111 chr2:191398756 TMEM194B -0.77 -14.86 -0.51 3.91e-43 Diastolic blood pressure; BRCA cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg01448562 chr3:133502909 NA -0.74 -17.48 -0.57 3.2e-56 Iron status biomarkers; BRCA cis rs56104184 0.830 rs55966626 chr19:49342396 G/T cg15549821 chr19:49342101 PLEKHA4 -1.06 -16.49 -0.55 3.59e-51 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs9296095 0.656 rs547391 chr6:33563913 T/A cg14003231 chr6:33640908 ITPR3 0.36 8.18 0.31 1.56e-15 Platelet count; BRCA cis rs6450176 1.000 rs3776706 chr5:53304933 T/G ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.55 -0.52 1.79e-46 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs6594499 0.872 rs13178997 chr5:110444249 G/T cg04022379 chr5:110408740 TSLP 0.35 7.97 0.3 7.58e-15 Allergic disease (asthma, hay fever or eczema); BRCA trans rs4714291 0.963 rs1721409 chr6:40112439 A/T cg02267698 chr19:7991119 CTXN1 0.42 8.21 0.31 1.27e-15 Strep throat; BRCA cis rs2075371 0.932 rs1862048 chr7:133978167 C/G cg11752832 chr7:134001865 SLC35B4 -0.44 -9.69 -0.36 8.15e-21 Mean platelet volume; BRCA cis rs57590327 0.503 rs1524557 chr3:81892031 A/G cg07356753 chr3:81810745 GBE1 -0.44 -10.41 -0.38 1.44e-23 Extraversion; BRCA cis rs68170813 0.559 rs17427123 chr7:106823661 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.83 -0.33 1e-17 Coronary artery disease; BRCA cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg24308560 chr3:49941425 MST1R -0.4 -8.55 -0.32 9.36e-17 Intelligence (multi-trait analysis); BRCA cis rs7246967 0.673 rs8106215 chr19:22879446 G/A cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg08645402 chr16:4508243 NA 0.42 9.74 0.36 5.44e-21 Schizophrenia; BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg12444411 chr7:2802554 GNA12 0.35 8.54 0.32 9.49e-17 Height; BRCA cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg06108461 chr20:60628389 TAF4 -0.99 -21.96 -0.66 4.49e-80 Body mass index; BRCA cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg25319279 chr11:5960081 NA -0.43 -8.4 -0.32 3e-16 DNA methylation (variation); BRCA cis rs7246657 0.722 rs10410588 chr19:38042410 C/G cg14683738 chr19:37701593 ZNF585B 0.46 7.92 0.3 1.02e-14 Coronary artery calcification; BRCA cis rs2050392 0.858 rs306583 chr10:30710057 C/T cg18806716 chr10:30721971 MAP3K8 0.34 7.98 0.3 6.83e-15 Inflammatory bowel disease; BRCA cis rs4594175 0.926 rs10138269 chr14:51615360 T/C cg23942311 chr14:51606299 NA 0.34 8.49 0.32 1.44e-16 Cancer; BRCA cis rs1865760 0.516 rs9379818 chr6:26023206 G/T cg16482183 chr6:26056742 HIST1H1C 0.52 11.24 0.41 6.95e-27 Height; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg10862848 chr6:42927986 GNMT -0.36 -15.23 -0.52 6.63e-45 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg00149659 chr3:10157352 C3orf10 0.77 12.6 0.45 1.1e-32 Alzheimer's disease; BRCA cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg20701182 chr2:24300061 SF3B14 0.58 9.01 0.34 2.37e-18 Lymphocyte counts; BRCA cis rs9309711 0.922 rs13399524 chr2:3480206 C/G cg16153549 chr2:3496821 NA -0.37 -8.63 -0.32 4.72e-17 Neurofibrillary tangles; BRCA cis rs4302748 0.909 rs11763993 chr7:36172486 G/A cg24442661 chr7:36192818 EEPD1 0.43 8.13 0.31 2.29e-15 Platelet count; BRCA trans rs208520 0.874 rs208473 chr6:66917265 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.3 -0.54 3.22e-50 Exhaled nitric oxide output; BRCA trans rs11098499 0.863 rs2306456 chr4:120472422 C/G cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.61e-15 Extrinsic epigenetic age acceleration; BRCA cis rs798554 0.655 rs798492 chr7:2799184 C/T cg18446336 chr7:2847575 GNA12 0.35 8.36 0.31 3.98e-16 Height; BRCA cis rs13102973 0.899 rs13127569 chr4:135900762 C/A cg14419869 chr4:135874104 NA 0.46 9.37 0.35 1.18e-19 Subjective well-being; BRCA cis rs17270561 0.609 rs4712960 chr6:25727265 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg04025307 chr7:1156635 C7orf50 0.57 13.46 0.47 1.61e-36 Longevity;Endometriosis; BRCA cis rs637571 0.676 rs1151523 chr11:65665200 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.42 -8.67 -0.32 3.53e-17 Eosinophil percentage of white cells; BRCA cis rs12497850 0.931 rs1134591 chr3:48972892 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.64 0.36 1.23e-20 Parkinson's disease; BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg10729496 chr3:10149963 C3orf24 0.49 9.3 0.35 2.22e-19 Alzheimer's disease; BRCA cis rs6137287 0.722 rs1007226 chr20:21103987 A/G cg04219410 chr20:21106687 PLK1S1 0.36 8.34 0.31 4.59e-16 Height; BRCA cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg14926445 chr8:58193284 C8orf71 -0.43 -8.57 -0.32 7.61e-17 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.15e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg13047869 chr3:10149882 C3orf24 -0.55 -12.13 -0.43 1.3e-30 Alzheimer's disease; BRCA cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg18876405 chr7:65276391 NA -0.52 -11.7 -0.42 8.87e-29 Aortic root size; BRCA cis rs4908768 0.501 rs6577494 chr1:8576925 C/T cg20416874 chr1:8611966 RERE -0.28 -8.2 -0.31 1.29e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg16049864 chr8:95962084 TP53INP1 0.48 10.62 0.39 2.17e-24 Type 2 diabetes; BRCA cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.4 -8.38 -0.31 3.37e-16 Ulcerative colitis; BRCA cis rs2204008 0.837 rs34381557 chr12:38181983 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg26647111 chr11:31128758 NA 0.44 9.74 0.36 5.46e-21 Red blood cell count; BRCA cis rs10924970 0.967 rs10754588 chr1:235438205 C/T cg26050004 chr1:235667680 B3GALNT2 0.35 8.69 0.33 3.01e-17 Asthma; BRCA cis rs2066819 1.000 rs59626664 chr12:56636975 C/G cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs7572733 0.534 rs1518363 chr2:198810131 C/T cg00792783 chr2:198669748 PLCL1 0.45 9.94 0.37 9.5e-22 Dermatomyositis; BRCA cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.8e-16 Monocyte percentage of white cells; BRCA cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.03 0.54 7.54e-49 Smoking behavior; BRCA cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg02196655 chr2:10830764 NOL10 0.3 7.92 0.3 1.05e-14 Prostate cancer; BRCA cis rs1997103 0.871 rs6956733 chr7:55393032 A/C cg17469321 chr7:55412551 NA 0.49 8.63 0.32 4.88e-17 QRS interval (sulfonylurea treatment interaction); BRCA trans rs1997103 0.911 rs17777 chr7:55380765 T/C cg20935933 chr6:143382018 AIG1 0.61 11.59 0.42 2.5e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg21535247 chr6:8435926 SLC35B3 0.39 8.74 0.33 2.06e-17 Motion sickness; BRCA cis rs3733585 0.598 rs28677023 chr4:9958326 C/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.3 8.18 0.31 1.55e-15 Intelligence (multi-trait analysis); BRCA cis rs1865760 1.000 rs3752421 chr6:25918688 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.53 0.38 5.05e-24 Height; BRCA cis rs4481887 0.893 rs10888348 chr1:248448610 C/G cg00666640 chr1:248458726 OR2T12 0.31 8.48 0.32 1.57e-16 Common traits (Other); BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 19.24 0.61 2.09e-65 Alzheimer's disease; BRCA cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg03526776 chr6:41159608 TREML2 0.43 8.0 0.3 5.81e-15 Alzheimer's disease (late onset); BRCA cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.48 -10.25 -0.38 6.49e-23 Bipolar disorder; BRCA trans rs8002861 0.619 rs1337203 chr13:44423621 T/G cg17145862 chr1:211918768 LPGAT1 0.47 10.76 0.39 6.31e-25 Leprosy; BRCA cis rs9290065 0.519 rs7644586 chr3:160674133 T/C cg03342759 chr3:160939853 NMD3 -0.5 -10.16 -0.37 1.34e-22 Kawasaki disease; BRCA cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg17691542 chr6:26056736 HIST1H1C 0.37 8.08 0.3 3.28e-15 Intelligence (multi-trait analysis); BRCA cis rs769267 0.566 rs9304962 chr19:19679992 G/C cg03709012 chr19:19516395 GATAD2A -0.5 -9.91 -0.36 1.26e-21 Tonsillectomy; BRCA cis rs2882667 0.690 rs995177 chr5:138169563 G/A cg04439458 chr5:138467593 SIL1 0.34 8.47 0.32 1.73e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg23649088 chr2:200775458 C2orf69 -0.63 -8.11 -0.31 2.61e-15 Schizophrenia; BRCA cis rs3750965 0.959 rs4930264 chr11:68852181 C/T cg06818126 chr11:68850279 TPCN2 -0.34 -8.14 -0.31 2.02e-15 Hair color; BRCA cis rs61931739 0.534 rs10844828 chr12:34303109 C/T cg06521331 chr12:34319734 NA -0.68 -14.68 -0.5 3.01e-42 Morning vs. evening chronotype; BRCA cis rs17604090 0.887 rs850013 chr7:29666530 T/C cg19413766 chr7:29689036 LOC646762 -0.49 -7.82 -0.3 2.2e-14 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg24642439 chr20:33292090 TP53INP2 0.62 13.99 0.48 5.7e-39 Coronary artery disease; BRCA cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg01262667 chr19:19385393 TM6SF2 -0.42 -10.79 -0.39 4.77e-25 Tonsillectomy; BRCA cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg09184832 chr6:79620586 NA -0.5 -11.19 -0.4 1.16e-26 Intelligence (multi-trait analysis); BRCA cis rs2806561 1.000 rs2806561 chr1:23504795 C/T cg19743168 chr1:23544995 NA -0.4 -9.53 -0.35 3.2e-20 Height; BRCA trans rs11088226 1.000 rs2833890 chr21:33927886 A/G cg09050820 chr6:167586206 TCP10L2 -0.49 -8.71 -0.33 2.5e-17 Gastritis; BRCA cis rs17401966 0.898 rs11587495 chr1:10448999 T/C cg19773385 chr1:10388646 KIF1B -0.38 -8.15 -0.31 1.93e-15 Hepatocellular carcinoma; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg14789911 chr21:47582049 C21orf56 -0.36 -7.99 -0.3 6.11e-15 Testicular germ cell tumor; BRCA cis rs3768617 0.811 rs11590958 chr1:183023636 T/C ch.1.3577855R chr1:183094577 LAMC1 0.44 9.7 0.36 7.76e-21 Fuchs's corneal dystrophy; BRCA cis rs4953076 0.533 rs10173126 chr2:44446492 T/C cg04920474 chr2:44395004 PPM1B 0.51 9.92 0.37 1.16e-21 Height; BRCA cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg26408565 chr15:76604113 ETFA -0.36 -7.87 -0.3 1.52e-14 Blood metabolite levels; BRCA cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg04450456 chr4:17643702 FAM184B 0.37 10.94 0.4 1.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs912057 1.000 rs912057 chr6:6736931 C/T cg06612196 chr6:6737390 NA -0.45 -10.29 -0.38 4.46e-23 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs13315871 1.000 rs9862969 chr3:58341917 A/G cg20936604 chr3:58311152 NA -0.63 -8.07 -0.3 3.42e-15 Cholesterol, total; BRCA trans rs208520 1.000 rs12212063 chr6:66985148 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 12.18 0.43 8.13e-31 Exhaled nitric oxide output; BRCA cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.78 0.42 4.07e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6450176 1.000 rs3776707 chr5:53304873 T/C ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.55 -0.52 1.79e-46 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg06238570 chr21:40685208 BRWD1 -0.4 -8.22 -0.31 1.16e-15 Menarche (age at onset); BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.54 -9.73 -0.36 5.69e-21 Renal function-related traits (BUN); BRCA cis rs6120849 0.901 rs6058193 chr20:33734464 A/G cg24642439 chr20:33292090 TP53INP2 0.48 8.52 0.32 1.18e-16 Protein C levels; BRCA cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 13.92 0.48 1.2e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg22764044 chr5:178986830 RUFY1 0.44 10.77 0.39 5.57e-25 Lung cancer; BRCA cis rs73086581 1.000 rs73086549 chr20:3954662 C/A cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.96e-21 Total body bone mineral density; BRCA cis rs35110281 0.774 rs162344 chr21:44954522 G/A cg01579765 chr21:45077557 HSF2BP -0.39 -10.25 -0.38 6.36e-23 Mean corpuscular volume; BRCA cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg26031613 chr14:104095156 KLC1 -0.43 -8.55 -0.32 9.31e-17 Schizophrenia; BRCA cis rs9837602 1.000 rs1038294 chr3:99503728 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -10.83 -0.39 3.42e-25 Breast cancer; BRCA cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg09035930 chr12:129282057 SLC15A4 0.5 13.98 0.48 6.25e-39 Systemic lupus erythematosus; BRCA cis rs2070997 0.667 rs2260323 chr9:133700786 C/T cg11464064 chr9:133710261 ABL1 -0.5 -9.15 -0.34 7.56e-19 Response to amphetamines; BRCA cis rs4242434 0.757 rs7005025 chr8:22519815 G/T cg03733263 chr8:22462867 KIAA1967 0.73 16.73 0.55 2.12e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA trans rs1459104 0.925 rs35019440 chr11:55218270 C/G cg15704280 chr7:45808275 SEPT13 0.64 8.15 0.31 1.95e-15 Body mass index; BRCA cis rs698833 0.828 rs6706053 chr2:44517662 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.44 -8.84 -0.33 9.1e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg20848291 chr7:100343083 ZAN 0.36 8.04 0.3 4.39e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg10802521 chr3:52805072 NEK4 -0.32 -8.34 -0.31 4.67e-16 Bipolar disorder; BRCA cis rs7512552 0.839 rs1260386 chr1:150369622 G/T cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.96e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg13736514 chr6:26305472 NA -0.35 -12.04 -0.43 3.2e-30 Educational attainment; BRCA cis rs2354432 0.607 rs12404113 chr1:146750343 C/A cg25205988 chr1:146714368 CHD1L -0.93 -12.28 -0.44 2.77e-31 Mitochondrial DNA levels; BRCA cis rs17401966 0.838 rs946501 chr1:10309580 C/G cg03954927 chr1:10346856 KIF1B 0.44 13.77 0.48 6.06e-38 Hepatocellular carcinoma; BRCA cis rs4363385 0.818 rs3820141 chr1:153004778 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.59 -0.32 6.68e-17 Inflammatory skin disease; BRCA cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.97 0.62 2.45e-69 Platelet count; BRCA trans rs9325144 0.555 rs12424003 chr12:38688140 C/T cg23762105 chr12:34175262 ALG10 0.36 8.27 0.31 7.73e-16 Morning vs. evening chronotype; BRCA cis rs4566357 0.595 rs2272203 chr2:227914655 C/G cg05526886 chr2:227700861 RHBDD1 -0.41 -8.57 -0.32 7.98e-17 Coronary artery disease; BRCA cis rs6942756 1.000 rs17168512 chr7:128955033 A/G cg02491457 chr7:128862824 NA -0.71 -14.0 -0.48 5.08e-39 White matter hyperintensity burden; BRCA cis rs9811920 0.893 rs6798114 chr3:99892825 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.51 11.68 0.42 1.06e-28 Axial length; BRCA cis rs6901250 0.851 rs339322 chr6:117193356 T/C cg12892004 chr6:117198278 RFX6 -0.49 -11.24 -0.41 6.81e-27 C-reactive protein levels; BRCA cis rs922182 0.547 rs6494458 chr15:64271095 A/C cg24729988 chr15:64271149 DAPK2 -0.71 -19.4 -0.61 2.91e-66 Blood protein levels; BRCA cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg08999081 chr20:33150536 PIGU -0.34 -8.69 -0.33 2.93e-17 Glomerular filtration rate (creatinine); BRCA cis rs17345786 0.520 rs1476123 chr3:101313413 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.39 9.11 0.34 1.05e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 1.000 rs10029750 chr4:120172543 A/G cg09307838 chr4:120376055 NA 0.6 12.21 0.44 5.54e-31 Corneal astigmatism; BRCA cis rs10782582 0.593 rs77733234 chr1:76101655 A/T cg10523679 chr1:76189770 ACADM -0.47 -9.0 -0.34 2.55e-18 Daytime sleep phenotypes; BRCA cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg07395648 chr5:131743802 NA 0.38 8.19 0.31 1.38e-15 Breast cancer; BRCA cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg21770322 chr7:97807741 LMTK2 0.45 11.84 0.42 2.23e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.5e-34 Asthma (sex interaction); BRCA cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.687 rs71610270 chr4:120287436 A/G cg25214090 chr10:38739885 LOC399744 0.49 11.41 0.41 1.47e-27 Corneal astigmatism; BRCA cis rs7927771 0.725 rs11039265 chr11:47523214 C/A cg18512352 chr11:47633146 NA -0.38 -9.1 -0.34 1.11e-18 Subjective well-being; BRCA cis rs1691799 0.899 rs1168294 chr12:66733988 T/C cg16791601 chr12:66731901 HELB -0.64 -17.13 -0.56 1.98e-54 White blood cell count (basophil); BRCA cis rs919433 0.680 rs67580728 chr2:198431258 C/T cg00792783 chr2:198669748 PLCL1 0.34 7.91 0.3 1.15e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg27170947 chr2:26402098 FAM59B -0.95 -17.03 -0.56 7.03e-54 Gut microbiome composition (summer); BRCA cis rs838147 0.760 rs412712 chr19:49234299 A/T cg13540341 chr19:49222985 MAMSTR 0.34 9.42 0.35 8.11e-20 Dietary macronutrient intake; BRCA cis rs2380220 0.606 rs4571572 chr6:96004823 T/C cg15832292 chr6:96025679 MANEA 0.52 8.58 0.32 7.34e-17 Behavioural disinhibition (generation interaction); BRCA cis rs4302748 0.862 rs4720196 chr7:36183300 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs6500602 0.592 rs4785966 chr16:4518754 C/T cg08645402 chr16:4508243 NA -0.37 -9.11 -0.34 1.06e-18 Schizophrenia; BRCA cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg20503657 chr10:835505 NA 0.98 14.92 0.51 2.13e-43 Eosinophil percentage of granulocytes; BRCA cis rs4363385 0.667 rs73014331 chr1:152964533 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -8.94 -0.33 4e-18 Inflammatory skin disease; BRCA cis rs2624839 0.704 rs14321 chr3:50226151 T/C cg14019146 chr3:50243930 SLC38A3 0.64 16.15 0.54 1.88e-49 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.21 -0.43 5.77e-31 Tonsillectomy; BRCA cis rs250677 0.958 rs36070 chr5:148417240 T/C cg18129178 chr5:148520854 ABLIM3 -0.59 -11.98 -0.43 5.71e-30 Breast cancer; BRCA cis rs921968 0.509 rs626432 chr2:219355658 C/A cg10223061 chr2:219282414 VIL1 -0.27 -7.82 -0.3 2.2e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs6867032 1.000 rs61177713 chr5:2017255 G/A cg26168224 chr5:2018326 NA 0.64 17.64 0.57 5.07e-57 Gut microbiome composition (winter); BRCA cis rs16866061 1.000 rs11681451 chr2:225334104 T/C cg12698349 chr2:225449008 CUL3 0.77 21.36 0.65 8.52e-77 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg19346786 chr7:2764209 NA -0.37 -10.8 -0.39 4.4e-25 Height; BRCA cis rs12711979 0.765 rs13030772 chr2:3821280 T/C cg17052675 chr2:3827356 NA -0.48 -14.31 -0.49 1.8e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg20503657 chr10:835505 NA -1.01 -18.63 -0.59 3.45e-62 Eosinophil percentage of granulocytes; BRCA cis rs875971 1.000 rs778699 chr7:65868290 G/A cg11764359 chr7:65958608 NA 0.81 19.65 0.61 1.26e-67 Aortic root size; BRCA cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg05084668 chr3:125655381 ALG1L -0.5 -9.51 -0.35 3.87e-20 Blood pressure (smoking interaction); BRCA cis rs2370759 1.000 rs2769241 chr10:32556229 T/C cg01819863 chr10:32635814 EPC1 -1.07 -18.93 -0.6 8.73e-64 Sexual dysfunction (female); BRCA cis rs78456975 0.943 rs6721243 chr2:1580250 A/G cg26248373 chr2:1572462 NA -0.54 -11.33 -0.41 3.17e-27 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg22467129 chr15:76604101 ETFA -0.5 -10.9 -0.4 1.7e-25 Blood metabolite levels; BRCA cis rs2204008 0.811 rs2139752 chr12:38370398 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.44 0.38 1.18e-23 Bladder cancer; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs2549003 0.934 rs2549006 chr5:131827065 A/G cg21138405 chr5:131827807 IRF1 -0.37 -11.65 -0.42 1.39e-28 Asthma (sex interaction); BRCA cis rs17270561 0.609 rs1408271 chr6:25859621 T/A cg16482183 chr6:26056742 HIST1H1C 0.51 10.32 0.38 3.34e-23 Iron status biomarkers; BRCA cis rs72781680 0.821 rs72790329 chr2:24129277 A/G cg08917208 chr2:24149416 ATAD2B 0.62 10.58 0.39 3.35e-24 Lymphocyte counts; BRCA cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg09184832 chr6:79620586 NA -0.47 -9.17 -0.34 6.22e-19 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs778697 chr7:65870426 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs2304069 0.909 rs30831 chr5:149359053 C/T cg12661370 chr5:149340060 SLC26A2 -0.56 -8.23 -0.31 1.07e-15 HIV-1 control; BRCA cis rs11098499 0.697 rs4373140 chr4:120307698 A/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs832540 0.669 rs173764 chr5:56198920 C/T cg20203395 chr5:56204925 C5orf35 -0.37 -8.39 -0.32 3.01e-16 Coronary artery disease; BRCA cis rs9394841 0.667 rs10807268 chr6:41777591 A/T cg08135965 chr6:41755394 TOMM6 0.5 8.21 0.31 1.19e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg08885076 chr2:99613938 TSGA10 -0.47 -8.99 -0.33 2.88e-18 Chronic sinus infection; BRCA cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg11266682 chr4:10021025 SLC2A9 -0.4 -9.98 -0.37 6.92e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.74 0.42 6.16e-29 Tonsillectomy; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.24 0.41 6.92e-27 Platelet count; BRCA cis rs1163251 0.869 rs629735 chr1:120206932 G/T cg19096424 chr1:120255104 PHGDH -0.42 -9.34 -0.35 1.62e-19 Blood metabolite levels; BRCA cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -12.63 -0.45 8.19e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg04166393 chr7:2884313 GNA12 0.4 8.47 0.32 1.74e-16 Height; BRCA cis rs4631830 0.720 rs11599333 chr10:51499655 A/C cg20129853 chr10:51489980 NA 0.32 8.65 0.32 4e-17 Prostate-specific antigen levels; BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.36 -0.31 3.88e-16 Gut microbiome composition (summer); BRCA cis rs9859260 0.710 rs41298097 chr3:195779155 C/T cg03462622 chr3:195777018 TFRC -0.38 -8.63 -0.32 4.86e-17 Mean corpuscular volume; BRCA cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.47 0.44 4.31e-32 Multiple sclerosis; BRCA cis rs6484504 0.625 rs7940420 chr11:31366700 T/A cg06552810 chr11:31128660 NA 0.39 8.61 0.32 5.84e-17 Red blood cell count; BRCA cis rs1593 0.565 rs10025152 chr4:187225304 C/T cg14349977 chr4:187219430 NA 0.53 10.04 0.37 3.95e-22 Activated partial thromboplastin time; BRCA cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg13877915 chr19:58951672 ZNF132 0.46 10.72 0.39 9.33e-25 Uric acid clearance; BRCA cis rs782590 0.694 rs2627775 chr2:55877113 C/T cg18811423 chr2:55921094 PNPT1 0.67 20.31 0.63 3.82e-71 Metabolic syndrome; BRCA cis rs7474896 0.583 rs11011341 chr10:37998500 G/A cg25427524 chr10:38739819 LOC399744 -0.52 -9.24 -0.34 3.56e-19 Obesity (extreme); BRCA cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -8.86 -0.33 8.09e-18 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg10495392 chr1:46806563 NSUN4 0.44 8.0 0.3 5.92e-15 Menopause (age at onset); BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg01262667 chr19:19385393 TM6SF2 0.41 10.58 0.39 3.35e-24 Tonsillectomy; BRCA trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg21518248 chr2:162101506 NA 0.49 10.24 0.38 6.77e-23 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.559 rs10487271 chr7:106898458 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.65 -0.32 4.02e-17 Coronary artery disease; BRCA cis rs9467773 1.000 rs9467773 chr6:26498426 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.28e-60 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs16941017 chr15:45543281 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.41 -0.41 1.37e-27 Uric acid levels; BRCA cis rs911119 1.000 rs6515375 chr20:23610841 G/A cg16589663 chr20:23618590 CST3 0.45 8.54 0.32 9.77e-17 Chronic kidney disease; BRCA cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg05707623 chr12:122985044 ZCCHC8 -0.49 -9.88 -0.36 1.55e-21 Body mass index; BRCA cis rs1865760 0.929 rs9358896 chr6:25943197 C/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.79 0.36 3.64e-21 Height; BRCA cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.7 10.84 0.39 3.06e-25 Lung function (FEV1/FVC); BRCA cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7592578 0.771 rs10432434 chr2:191387079 T/G cg10560079 chr2:191398806 TMEM194B -0.74 -13.7 -0.48 1.19e-37 Diastolic blood pressure; BRCA cis rs7617773 0.817 rs6800492 chr3:48323890 G/A cg11946769 chr3:48343235 NME6 0.63 13.42 0.47 2.33e-36 Coronary artery disease; BRCA cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.67 0.55 4.69e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs6547741 0.935 rs2384626 chr2:27773648 A/G cg27432699 chr2:27873401 GPN1 0.47 9.83 0.36 2.56e-21 Oral cavity cancer; BRCA cis rs2073300 1.000 rs79169006 chr20:23443535 A/T cg12062639 chr20:23401060 NAPB 0.88 10.43 0.38 1.28e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs701145 0.537 rs1727952 chr3:153871565 C/T cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg08975724 chr8:8085496 FLJ10661 0.48 10.29 0.38 4.42e-23 Mood instability; BRCA cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg11941060 chr3:133502564 NA -0.5 -11.89 -0.43 1.35e-29 Iron status biomarkers; BRCA cis rs3917254 0.509 rs13035227 chr2:102763837 T/C cg22835712 chr2:102737379 NA -0.52 -8.79 -0.33 1.33e-17 Blood protein levels; BRCA trans rs12517041 0.872 rs67191421 chr5:23281046 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.27 -0.31 7.73e-16 Calcium levels; BRCA cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg24812749 chr6:127587940 RNF146 0.88 20.25 0.63 8.34e-71 Breast cancer; BRCA cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg05234568 chr11:5960015 NA -0.48 -9.58 -0.35 2.14e-20 DNA methylation (variation); BRCA cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs2658782 1.000 rs2658779 chr11:93163137 G/T cg15737290 chr11:93063684 CCDC67 -0.49 -9.75 -0.36 4.95e-21 Pulmonary function decline; BRCA cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg06784218 chr1:46089804 CCDC17 0.49 11.52 0.41 4.73e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2204008 0.782 rs11514339 chr12:38236670 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.83e-22 Bladder cancer; BRCA cis rs9324022 0.858 rs1004572 chr14:101178330 G/A cg18089426 chr14:101175970 NA 0.59 11.28 0.41 4.7e-27 Plateletcrit; BRCA cis rs57590327 0.504 rs11712243 chr3:81840674 T/G cg07356753 chr3:81810745 GBE1 -0.47 -11.07 -0.4 3.54e-26 Extraversion; BRCA cis rs1003719 0.667 rs8127148 chr21:38481292 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.57 13.21 0.46 2.11e-35 Eye color traits; BRCA cis rs13190036 1.000 rs13177748 chr5:176643954 T/G cg06733329 chr5:176740039 MXD3 0.45 8.21 0.31 1.2e-15 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg08132940 chr7:1081526 C7orf50 -0.46 -8.39 -0.32 3.02e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11051970 0.661 rs188979 chr12:32569684 G/T cg24626660 chr12:32551988 NA 0.31 9.03 0.34 2.04e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg02297831 chr4:17616191 MED28 0.36 8.47 0.32 1.67e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6964587 0.967 rs10248102 chr7:91699779 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg20701182 chr2:24300061 SF3B14 0.65 9.37 0.35 1.2e-19 Lymphocyte counts; BRCA cis rs9914988 0.943 rs9894335 chr17:27138483 C/A cg20469991 chr17:27169893 C17orf63 -0.44 -8.66 -0.32 3.88e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg11764359 chr7:65958608 NA -0.75 -17.64 -0.57 4.71e-57 Aortic root size; BRCA cis rs738322 0.967 rs4383 chr22:38570927 C/G cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg00321850 chr1:175162397 KIAA0040 0.44 12.39 0.44 9.15e-32 Diastolic blood pressure; BRCA cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA trans rs11098499 0.908 rs11729050 chr4:120300066 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg11663144 chr21:46675770 NA -0.55 -12.75 -0.45 2.41e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg17366294 chr4:99064904 C4orf37 0.43 9.67 0.36 9.64e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg11764359 chr7:65958608 NA 0.78 18.57 0.59 7.06e-62 Aortic root size; BRCA cis rs9486715 0.867 rs11152924 chr6:96877383 A/G cg06623918 chr6:96969491 KIAA0776 0.9 25.45 0.71 3.19e-99 Headache; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.18 -0.4 1.27e-26 Extrinsic epigenetic age acceleration; BRCA cis rs17539620 0.534 rs7768635 chr6:154827861 C/T cg20019720 chr6:154832845 CNKSR3 0.5 11.78 0.42 4.1e-29 Lipoprotein (a) levels; BRCA cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs11722228 0.522 rs12504600 chr4:10067138 C/A cg26043149 chr18:55253948 FECH 1.03 21.7 0.65 1.15e-78 Gout;Urate levels;Serum uric acid levels; BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg21747090 chr2:27597821 SNX17 -0.43 -9.4 -0.35 9.66e-20 Total body bone mineral density; BRCA cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.41 -9.63 -0.36 1.43e-20 Tonsillectomy; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.6 -11.1 -0.4 2.74e-26 Renal function-related traits (BUN); BRCA cis rs7301016 0.901 rs12369961 chr12:62966584 C/T cg01804193 chr12:63026212 NA 0.47 8.56 0.32 8.12e-17 IgG glycosylation; BRCA cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.32 -10.29 -0.38 4.29e-23 Bipolar disorder; BRCA cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg25237894 chr2:233734115 C2orf82 0.39 11.36 0.41 2.39e-27 Coronary artery disease; BRCA cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.525 rs1177274 chr2:61368532 T/G cg15711740 chr2:61764176 XPO1 -0.47 -11.87 -0.43 1.66e-29 Tuberculosis; BRCA cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.59 13.47 0.47 1.38e-36 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7020830 0.931 rs13288178 chr9:37107799 A/G cg14294708 chr9:37120828 ZCCHC7 1.17 36.62 0.82 4.66e-159 Schizophrenia; BRCA cis rs701145 0.537 rs1713831 chr3:153836299 T/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.2e-14 Coronary artery disease; BRCA cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.76 -0.39 6.3e-25 Personality dimensions; BRCA cis rs1997103 0.871 rs1997101 chr7:55399652 A/T cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs12579753 1.000 rs7966755 chr12:82221604 A/G cg07988820 chr12:82153109 PPFIA2 -0.63 -10.3 -0.38 3.95e-23 Resting heart rate; BRCA cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.85e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs919433 0.963 rs2043016 chr2:198146381 C/T cg03934865 chr2:198174659 NA -0.38 -8.29 -0.31 6.5e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs1997103 1.000 rs2331063 chr7:55408914 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs13046373 0.535 rs7276743 chr21:31984545 C/T cg14062083 chr21:31802829 KRTAP13-4 0.32 8.42 0.32 2.44e-16 HDL cholesterol; BRCA cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg15485101 chr11:133734466 NA 0.4 10.14 0.37 1.73e-22 Childhood ear infection; BRCA cis rs34779708 0.931 rs4934535 chr10:35432721 G/T cg03585969 chr10:35415529 CREM 0.56 11.6 0.42 2.21e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7520050 0.931 rs11211198 chr1:46282673 G/A cg24296786 chr1:45957014 TESK2 0.44 9.85 0.36 2.07e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.5 -0.44 2.98e-32 Bipolar disorder; BRCA cis rs1865760 0.566 rs9358904 chr6:26068566 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 11.48 0.41 7.34e-28 Height; BRCA cis rs6598955 0.627 rs3924324 chr1:26616280 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -8.29 -0.31 6.54e-16 Obesity-related traits; BRCA cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg26248373 chr2:1572462 NA -0.5 -9.65 -0.36 1.16e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3784262 0.565 rs9635346 chr15:58298118 C/G cg12031962 chr15:58353849 ALDH1A2 0.33 8.57 0.32 7.64e-17 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg10802521 chr3:52805072 NEK4 -0.31 -8.08 -0.3 3.18e-15 Bipolar disorder; BRCA cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg13319975 chr6:146136371 FBXO30 0.45 10.42 0.38 1.41e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg01579765 chr21:45077557 HSF2BP -0.37 -9.87 -0.36 1.8e-21 Mean corpuscular volume; BRCA trans rs10411161 0.702 rs8110461 chr19:52383569 A/C cg22319618 chr22:45562946 NUP50 -0.41 -7.84 -0.3 1.95e-14 Breast cancer; BRCA cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.4 -0.35 9.22e-20 Body mass index; BRCA cis rs4722166 1.000 rs4722166 chr7:22738762 G/T cg05472934 chr7:22766657 IL6 0.49 10.79 0.39 4.78e-25 Lung cancer; BRCA cis rs2762353 0.935 rs1165215 chr6:25798932 G/A cg03517284 chr6:25882590 NA -0.46 -10.44 -0.38 1.11e-23 Blood metabolite levels; BRCA cis rs4363385 0.747 rs1015995 chr1:152976114 G/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg22467129 chr15:76604101 ETFA -0.39 -8.67 -0.32 3.66e-17 Blood metabolite levels; BRCA cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg05868516 chr6:26286170 HIST1H4H 0.43 8.39 0.32 3.1e-16 Educational attainment; BRCA cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs11190604 0.790 rs11190535 chr10:102197441 A/T cg07080220 chr10:102295463 HIF1AN 0.44 9.7 0.36 7.66e-21 Palmitoleic acid (16:1n-7) levels; BRCA trans rs35110281 0.712 rs1454648 chr21:45053815 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 9.87 0.36 1.72e-21 Mean corpuscular volume; BRCA cis rs3760982 0.585 rs8109812 chr19:44298494 C/A cg11993925 chr19:44307056 LYPD5 0.37 8.89 0.33 6.39e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg18765753 chr7:1198926 ZFAND2A -0.46 -10.42 -0.38 1.41e-23 Longevity;Endometriosis; BRCA cis rs7927592 0.871 rs55953412 chr11:68328283 C/T cg20283391 chr11:68216788 NA -0.46 -9.05 -0.34 1.66e-18 Total body bone mineral density; BRCA trans rs7939886 0.920 rs12226441 chr11:55867822 G/A cg15704280 chr7:45808275 SEPT13 0.61 7.93 0.3 1.01e-14 Myopia (pathological); BRCA cis rs2070997 0.667 rs13295907 chr9:133718242 G/T cg11464064 chr9:133710261 ABL1 0.53 9.6 0.35 1.84e-20 Response to amphetamines; BRCA cis rs6598955 0.671 rs12068212 chr1:26612935 C/T cg04990556 chr1:26633338 UBXN11 0.54 9.01 0.34 2.4e-18 Obesity-related traits; BRCA cis rs3820928 0.605 rs4281898 chr2:227855493 A/C cg11843606 chr2:227700838 RHBDD1 -0.49 -11.16 -0.4 1.45e-26 Pulmonary function; BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg16606324 chr3:10149918 C3orf24 0.57 10.02 0.37 4.74e-22 Alzheimer's disease; BRCA trans rs3960554 0.932 rs11971220 chr7:75842792 C/T cg19862616 chr7:65841803 NCRNA00174 0.6 11.68 0.42 1.08e-28 Eotaxin levels; BRCA cis rs559928 0.557 rs7122408 chr11:63898826 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.27 0.41 5.55e-27 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00149659 chr3:10157352 C3orf10 0.81 14.21 0.49 5.29e-40 Alzheimer's disease; BRCA cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.31 0.38 3.78e-23 Motion sickness; BRCA trans rs11088226 0.681 rs1134747 chr21:33939011 T/A cg09050820 chr6:167586206 TCP10L2 0.77 13.24 0.46 1.49e-35 Gastritis; BRCA cis rs796364 0.951 rs971232 chr2:200792881 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.28 0.46 1.07e-35 Schizophrenia; BRCA cis rs2625529 0.652 rs12148078 chr15:72300471 G/C cg16672083 chr15:72433130 SENP8 0.7 16.85 0.55 5.43e-53 Red blood cell count; BRCA cis rs250677 0.958 rs43147 chr5:148417103 C/G cg18129178 chr5:148520854 ABLIM3 0.58 11.62 0.42 1.88e-28 Breast cancer; BRCA cis rs7172677 0.737 rs7178625 chr15:75441017 A/G cg10253484 chr15:75165896 SCAMP2 -0.45 -8.46 -0.32 1.8e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7819412 0.521 rs9329238 chr8:11033737 C/T cg21775007 chr8:11205619 TDH -0.47 -9.7 -0.36 7.84e-21 Triglycerides; BRCA cis rs7666738 0.830 rs4392515 chr4:98957431 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4237845 0.514 rs4760339 chr12:58268149 G/T cg00677455 chr12:58241039 CTDSP2 0.69 15.97 0.53 1.46e-48 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.77 -13.59 -0.47 3.78e-37 Gut microbiome composition (summer); BRCA cis rs2294693 0.947 rs9349176 chr6:40989525 C/T cg14418226 chr6:40996092 UNC5CL 0.45 8.28 0.31 7.4e-16 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs9790314 0.875 rs163327 chr3:161062724 A/G cg03342759 chr3:160939853 NMD3 -0.59 -12.96 -0.46 2.73e-34 Morning vs. evening chronotype; BRCA cis rs9818758 0.545 rs55921200 chr3:49189316 T/C cg01304814 chr3:48885189 PRKAR2A 0.79 8.09 0.3 3.07e-15 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg24829409 chr8:58192753 C8orf71 -0.49 -9.45 -0.35 6.51e-20 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11644478 chr21:40555479 PSMG1 0.75 15.36 0.52 1.5e-45 Cognitive function; BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg00149659 chr3:10157352 C3orf10 0.79 13.66 0.48 1.77e-37 Alzheimer's disease; BRCA cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.77 -21.18 -0.64 8.35e-76 Multiple sclerosis; BRCA cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg06238570 chr21:40685208 BRWD1 -0.47 -9.26 -0.34 3.16e-19 Cognitive function; BRCA trans rs2204008 0.754 rs11514074 chr12:38401128 C/T cg06521331 chr12:34319734 NA -0.51 -9.16 -0.34 7.04e-19 Bladder cancer; BRCA cis rs8005677 1.000 rs4981446 chr14:23381413 A/G cg01529538 chr14:23388837 RBM23 0.42 11.48 0.41 7.35e-28 Cognitive ability (multi-trait analysis); BRCA cis rs10463316 0.862 rs59390562 chr5:150776092 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -8.32 -0.31 5.34e-16 Metabolite levels (Pyroglutamine); BRCA cis rs10838687 1.000 rs6485751 chr11:47336442 G/C cg25783544 chr11:47291846 MADD 0.42 8.45 0.32 2.04e-16 Proinsulin levels; BRCA cis rs17253792 0.731 rs28587929 chr14:56097492 C/T cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg20090143 chr19:45452003 APOC2 0.27 7.89 0.3 1.31e-14 Blood protein levels; BRCA cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.38 -0.38 1.96e-23 Personality dimensions; BRCA cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.05 -0.3 4.13e-15 Bipolar disorder; BRCA cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg04450456 chr4:17643702 FAM184B 0.39 11.6 0.42 2.34e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs924607 1.000 rs12523022 chr5:598643 C/T cg09021430 chr5:549028 NA 0.43 12.33 0.44 1.66e-31 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg21132104 chr15:45694354 SPATA5L1 0.7 15.6 0.53 9.98e-47 Homoarginine levels; BRCA cis rs4742903 0.509 rs7020317 chr9:106872682 T/A cg14250997 chr9:106856677 SMC2 0.27 8.03 0.3 4.71e-15 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg12193833 chr17:30244370 NA -0.6 -9.35 -0.35 1.42e-19 Hip circumference adjusted for BMI; BRCA cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg12350822 chr6:88032061 C6orf162;GJB7 0.42 11.86 0.42 1.84e-29 Monocyte percentage of white cells; BRCA cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg20302533 chr7:39170763 POU6F2 0.37 7.96 0.3 8.05e-15 IgG glycosylation; BRCA cis rs7172677 0.737 rs7179426 chr15:75441488 A/G cg14664628 chr15:75095509 CSK -0.36 -7.81 -0.3 2.3e-14 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg26408565 chr15:76604113 ETFA -0.39 -8.43 -0.32 2.33e-16 Blood metabolite levels; BRCA cis rs8180040 0.726 rs61729713 chr3:47027192 A/G cg02527881 chr3:46936655 PTH1R 0.35 8.9 0.33 5.55e-18 Colorectal cancer; BRCA cis rs473651 0.935 rs474478 chr2:239335473 C/T cg21699342 chr2:239360505 ASB1 0.53 14.05 0.49 2.92e-39 Multiple system atrophy; BRCA cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg05340658 chr4:99064831 C4orf37 0.66 16.08 0.54 4.09e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.73 0.36 5.88e-21 Gut microbiome composition (summer); BRCA cis rs3820928 0.874 rs2228557 chr2:227872182 G/A cg11843606 chr2:227700838 RHBDD1 -0.36 -7.99 -0.3 6.28e-15 Pulmonary function; BRCA trans rs62103177 0.608 rs4799115 chr18:77736365 A/T cg05926928 chr17:57297772 GDPD1 -0.8 -11.81 -0.42 3.04e-29 Opioid sensitivity; BRCA cis rs832540 0.669 rs173764 chr5:56198920 C/T cg22800045 chr5:56110881 MAP3K1 0.42 8.6 0.32 6.21e-17 Coronary artery disease; BRCA cis rs1163251 0.902 rs640195 chr1:120217650 T/A cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.73 11.73 0.42 6.69e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg08885076 chr2:99613938 TSGA10 0.43 10.31 0.38 3.72e-23 Chronic sinus infection; BRCA cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg14582100 chr15:45693742 SPATA5L1 0.37 11.87 0.42 1.71e-29 Homoarginine levels; BRCA cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg01528321 chr10:82214614 TSPAN14 0.64 14.52 0.5 1.65e-41 Post bronchodilator FEV1; BRCA trans rs12439619 0.846 rs62010071 chr15:82581783 G/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -7.81 -0.3 2.38e-14 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs56399783 0.708 rs56208415 chr7:2813806 G/A cg19731401 chr7:2775893 GNA12 0.48 8.35 0.31 4.14e-16 Childhood ear infection; BRCA cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg03060546 chr3:49711283 APEH 0.5 10.76 0.39 6.45e-25 Resting heart rate; BRCA cis rs12714314 0.830 rs12612812 chr2:1962131 A/C cg22511877 chr2:1942942 MYT1L 0.38 8.15 0.31 1.98e-15 Type 2 diabetes (age of onset); BRCA cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg24112000 chr20:60950667 NA -0.6 -13.49 -0.47 1.17e-36 Colorectal cancer; BRCA trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg27661571 chr11:113659931 NA -0.7 -10.86 -0.39 2.59e-25 Hip circumference adjusted for BMI; BRCA cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.4 -0.47 3.01e-36 Developmental language disorder (linguistic errors); BRCA cis rs11105298 0.891 rs10858899 chr12:89923811 G/C cg00757033 chr12:89920650 WDR51B 0.54 11.15 0.4 1.63e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs12612619 0.579 rs41448746 chr2:27080706 A/G cg12368169 chr2:27073192 DPYSL5 -0.33 -10.0 -0.37 5.87e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg11663144 chr21:46675770 NA -0.6 -13.82 -0.48 3.24e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs6952808 0.964 rs6945719 chr7:1932688 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 8.74 0.33 2.05e-17 Bipolar disorder and schizophrenia; BRCA cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.4 8.85 0.33 8.71e-18 Aortic root size; BRCA cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg11366901 chr6:160182831 ACAT2 0.82 15.87 0.53 4.47e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs634534 0.562 rs642293 chr11:65730217 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 9.91 0.37 1.19e-21 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs3125734 0.633 rs4561099 chr10:64041163 T/C cg09941381 chr10:64027924 RTKN2 -0.28 -8.19 -0.31 1.44e-15 Rheumatoid arthritis; BRCA cis rs1595825 0.838 rs80172713 chr2:198508044 T/C cg19156104 chr2:198669113 PLCL1 -0.46 -8.59 -0.32 6.53e-17 Ulcerative colitis; BRCA cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 9.47 0.35 5.24e-20 Electroencephalogram traits; BRCA cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.69e-23 Motion sickness; BRCA cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg03709012 chr19:19516395 GATAD2A 0.75 17.06 0.56 4.72e-54 Tonsillectomy; BRCA cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg04756594 chr16:24857601 SLC5A11 0.34 8.38 0.31 3.46e-16 Intelligence (multi-trait analysis); BRCA trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg03929089 chr4:120376271 NA 0.72 14.73 0.5 1.63e-42 Coronary artery disease; BRCA trans rs1005277 0.505 rs200936 chr10:38134935 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -9.63 -0.36 1.33e-20 Extrinsic epigenetic age acceleration; BRCA cis rs11146838 1 rs11146838 chr10:39149977 A/T cg17219203 chr10:38645113 HSD17B7P2 -0.43 -8.27 -0.31 7.86e-16 Breast cancer; BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg25173405 chr17:45401733 C17orf57 -0.5 -9.87 -0.36 1.73e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.02 -0.37 4.67e-22 Alzheimer's disease (late onset); BRCA cis rs735396 0.595 rs1169279 chr12:121455873 C/T cg25281562 chr12:121454272 C12orf43 0.35 9.15 0.34 7.6e-19 N-glycan levels; BRCA cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg12386194 chr3:101231763 SENP7 0.46 9.84 0.36 2.37e-21 Colorectal cancer; BRCA cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg20607287 chr7:12443886 VWDE -0.6 -8.53 -0.32 1.08e-16 Coronary artery disease; BRCA cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg23719950 chr11:63933701 MACROD1 -0.54 -8.79 -0.33 1.36e-17 Mean platelet volume; BRCA cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg10932868 chr11:921992 NA 0.47 11.85 0.42 1.99e-29 Alzheimer's disease (late onset); BRCA trans rs7647973 0.626 rs12715437 chr3:49751856 T/C cg21659725 chr3:3221576 CRBN -0.47 -8.64 -0.32 4.67e-17 Menarche (age at onset); BRCA cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg22535103 chr8:58192502 C8orf71 -0.44 -8.87 -0.33 7.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg04166393 chr7:2884313 GNA12 0.4 8.54 0.32 9.97e-17 Height; BRCA cis rs495337 0.760 rs6067282 chr20:48569278 T/C cg17835207 chr20:48524531 SPATA2 -0.69 -16.72 -0.55 2.51e-52 Psoriasis; BRCA cis rs782590 0.764 rs2586969 chr2:55829392 G/C cg18811423 chr2:55921094 PNPT1 0.68 20.87 0.64 3.62e-74 Metabolic syndrome; BRCA cis rs17023223 0.537 rs66715579 chr1:119725432 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs7809950 0.834 rs3801946 chr7:107242995 T/A cg23024343 chr7:107201750 COG5 0.42 9.18 0.34 5.8e-19 Coronary artery disease; BRCA cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.07 0.43 2.39e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg13010199 chr12:38710504 ALG10B 0.5 9.87 0.36 1.74e-21 Bladder cancer; BRCA cis rs2070488 0.804 rs13059256 chr3:38504315 T/C cg24069376 chr3:38537580 EXOG 0.32 9.08 0.34 1.35e-18 Electrocardiographic conduction measures; BRCA cis rs9611198 0.765 rs5757721 chr22:39947574 A/G cg03390717 chr22:39966585 CACNA1I 0.28 8.51 0.32 1.26e-16 Schizophrenia; BRCA cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs921968 0.643 rs832802 chr2:219386899 C/T cg02176678 chr2:219576539 TTLL4 0.39 10.47 0.38 8.73e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg16339924 chr4:17578868 LAP3 0.63 15.65 0.53 5.75e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11227306 0.934 rs7940691 chr11:65640906 C/T cg17712092 chr4:129076599 LARP1B -0.38 -8.28 -0.31 6.99e-16 DNA methylation (variation); BRCA cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg08917208 chr2:24149416 ATAD2B 0.9 12.92 0.46 4.27e-34 Lymphocyte counts; BRCA cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg16482183 chr6:26056742 HIST1H1C 0.5 10.69 0.39 1.16e-24 Height; BRCA cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg08564027 chr20:61660810 NA 0.84 22.49 0.66 5.99e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg04944784 chr2:26401820 FAM59B -0.84 -12.93 -0.46 3.78e-34 Gut microbiome composition (summer); BRCA cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.34 -0.49 1.29e-40 Chronic sinus infection; BRCA cis rs921968 0.541 rs3770214 chr2:219508988 C/T cg02176678 chr2:219576539 TTLL4 -0.5 -12.84 -0.45 9.49e-34 Mean corpuscular hemoglobin concentration; BRCA trans rs7980799 0.716 rs1601008 chr12:33611352 A/G cg26384229 chr12:38710491 ALG10B -0.49 -10.77 -0.39 5.98e-25 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2070488 1.000 rs13072809 chr3:38468171 G/A cg24069376 chr3:38537580 EXOG 0.41 11.68 0.42 1.01e-28 Electrocardiographic conduction measures; BRCA cis rs11231017 0.507 rs10792346 chr11:62140069 A/C cg23876832 chr11:62092739 NA -0.33 -8.31 -0.31 5.62e-16 HIV-1 viral setpoint; BRCA cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 13.86 0.48 2.2e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6424115 0.708 rs13551 chr1:24180962 T/C cg10978503 chr1:24200527 CNR2 -0.45 -10.33 -0.38 3.01e-23 Immature fraction of reticulocytes; BRCA trans rs6582630 0.519 rs11514372 chr12:38308613 T/G cg06521331 chr12:34319734 NA -0.47 -8.66 -0.32 3.96e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg15556689 chr8:8085844 FLJ10661 0.46 12.83 0.45 1.13e-33 Mood instability; BRCA cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.26 0.38 5.81e-23 Bipolar disorder; BRCA cis rs10463316 0.862 rs7720582 chr5:150776502 C/T cg03212797 chr5:150827313 SLC36A1 0.44 8.72 0.33 2.44e-17 Metabolite levels (Pyroglutamine); BRCA cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg15017067 chr4:17643749 FAM184B -0.28 -8.51 -0.32 1.2e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg08508325 chr11:3079039 CARS -0.41 -14.63 -0.5 5.31e-42 Longevity; BRCA cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg18404041 chr3:52824283 ITIH1 0.35 10.79 0.39 4.74e-25 Electroencephalogram traits; BRCA cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg26031613 chr14:104095156 KLC1 -0.43 -8.48 -0.32 1.57e-16 Schizophrenia; BRCA cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg03806693 chr22:41940476 POLR3H -0.9 -17.54 -0.57 1.65e-56 Vitiligo; BRCA cis rs17270561 0.609 rs9348694 chr6:25753640 C/T cg16482183 chr6:26056742 HIST1H1C 0.44 8.66 0.32 3.97e-17 Iron status biomarkers; BRCA cis rs2288327 0.643 rs16866334 chr2:179336672 A/G cg11548914 chr2:179343871 FKBP7;PLEKHA3;MIR548N 0.53 8.96 0.33 3.55e-18 Atrial fibrillation; BRCA cis rs965469 0.779 rs6037541 chr20:3287704 G/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.8 -0.33 1.22e-17 IFN-related cytopenia; BRCA cis rs10504073 0.565 rs12056536 chr8:49890132 C/T cg00325661 chr8:49890786 NA -0.49 -14.43 -0.5 4.68e-41 Blood metabolite ratios; BRCA cis rs5758659 0.652 rs129857 chr22:42399686 C/T cg15557168 chr22:42548783 NA 0.31 8.67 0.32 3.48e-17 Cognitive function; BRCA cis rs9308433 0.643 rs955920 chr1:214464309 G/A cg06198575 chr1:214491504 SMYD2 0.52 10.92 0.4 1.44e-25 IgG glycosylation; BRCA cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg13770153 chr20:60521292 NA -0.45 -10.81 -0.39 4.09e-25 Body mass index; BRCA cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.69 12.47 0.44 4.06e-32 IgG glycosylation; BRCA cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24308560 chr3:49941425 MST1R -0.41 -8.57 -0.32 7.77e-17 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.935 rs379164 chr6:145829093 A/T cg23711669 chr6:146136114 FBXO30 0.64 15.13 0.51 1.91e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg14343924 chr8:8086146 FLJ10661 0.42 8.81 0.33 1.13e-17 Mood instability; BRCA cis rs3771570 1.000 rs62193204 chr2:242315443 A/G cg21155796 chr2:242212141 HDLBP 0.6 9.21 0.34 4.8e-19 Prostate cancer; BRCA trans rs8073060 0.614 rs225275 chr17:33972567 G/C cg19694781 chr19:47549865 TMEM160 -1.05 -21.76 -0.65 5.94e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg13047869 chr3:10149882 C3orf24 0.53 10.94 0.4 1.14e-25 Alzheimer's disease; BRCA trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg03929089 chr4:120376271 NA 0.48 8.12 0.31 2.36e-15 Axial length; BRCA cis rs3820928 0.605 rs13410141 chr2:227805529 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -8.88 -0.33 6.5e-18 Pulmonary function; BRCA cis rs8010715 0.804 rs1134334 chr14:24594114 A/G cg23112188 chr14:24563095 PCK2 -0.33 -8.28 -0.31 7.35e-16 IgG glycosylation; BRCA cis rs7809950 0.817 rs17154091 chr7:107084790 T/C cg23024343 chr7:107201750 COG5 -0.52 -10.58 -0.39 3.39e-24 Coronary artery disease; BRCA cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.83 -0.3 1.98e-14 Bipolar disorder; BRCA cis rs6740322 0.895 rs6744746 chr2:43555805 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.65 11.98 0.43 5.45e-30 Coronary artery disease; BRCA cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg14019146 chr3:50243930 SLC38A3 0.42 10.14 0.37 1.61e-22 Body mass index; BRCA cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg08999081 chr20:33150536 PIGU 0.36 9.27 0.34 2.9e-19 Coronary artery disease; BRCA cis rs17270561 0.609 rs4712965 chr6:25742022 G/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs7587476 0.822 rs6726763 chr2:215681580 T/G cg04004882 chr2:215674386 BARD1 0.67 12.41 0.44 8.16e-32 Neuroblastoma; BRCA cis rs7072216 0.655 rs3830024 chr10:100176106 G/A cg26618903 chr10:100175079 PYROXD2 -0.32 -8.93 -0.33 4.6e-18 Metabolite levels; BRCA cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg11941060 chr3:133502564 NA -0.51 -12.42 -0.44 6.79e-32 Iron status biomarkers; BRCA cis rs727479 0.502 rs1065779 chr15:51504811 A/C cg19946085 chr15:51559439 CYP19A1 -0.31 -8.72 -0.33 2.44e-17 Estradiol levels; BRCA cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg00012203 chr2:219082015 ARPC2 0.49 9.72 0.36 6.57e-21 Colorectal cancer; BRCA cis rs265548 0.646 rs36692 chr19:17906839 C/T cg21960279 chr19:17905606 B3GNT3 0.48 10.85 0.39 2.78e-25 Tumor biomarkers; BRCA cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg13010199 chr12:38710504 ALG10B 0.52 10.48 0.38 8.03e-24 Bladder cancer; BRCA cis rs9457247 0.663 rs9459839 chr6:167431829 T/C cg07741184 chr6:167504864 NA 0.27 7.83 0.3 1.98e-14 Crohn's disease; BRCA cis rs1267303 0.642 rs1267301 chr1:46992853 C/G cg25110126 chr1:46999211 NA -0.72 -12.53 -0.44 2.23e-32 Monobrow; BRCA cis rs12348691 0.503 rs7847259 chr9:100600712 A/G cg13688889 chr9:100608707 NA -0.49 -9.94 -0.37 9.46e-22 Alopecia areata; BRCA cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg23887609 chr12:130822674 PIWIL1 0.43 9.35 0.35 1.47e-19 Menopause (age at onset); BRCA cis rs2882667 0.690 rs825758 chr5:138126977 G/A cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg11764359 chr7:65958608 NA 0.78 18.66 0.59 2.47e-62 Aortic root size; BRCA cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg19077165 chr18:44547161 KATNAL2 0.37 7.97 0.3 7.15e-15 Personality dimensions; BRCA cis rs9527 0.637 rs7085104 chr10:104628873 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.09 0.37 2.49e-22 Arsenic metabolism; BRCA cis rs317689 0.690 rs618470 chr12:69672060 A/G cg20891283 chr12:69753455 YEATS4 0.42 8.29 0.31 6.76e-16 Response to diuretic therapy; BRCA cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.71 10.85 0.39 2.72e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg03929089 chr4:120376271 NA 0.63 12.47 0.44 4.07e-32 Coronary artery disease; BRCA trans rs2197308 0.765 rs11182900 chr12:37934009 C/T cg06521331 chr12:34319734 NA -0.54 -9.58 -0.35 2.16e-20 Morning vs. evening chronotype; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.7 0.36 7.35e-21 Gut microbiome composition (summer); BRCA cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg24642439 chr20:33292090 TP53INP2 -0.41 -8.56 -0.32 8.61e-17 Height; BRCA cis rs8067545 0.750 rs4925077 chr17:19982276 C/T cg13482628 chr17:19912719 NA 0.54 14.89 0.51 2.99e-43 Schizophrenia; BRCA cis rs2481665 0.739 rs6674622 chr1:62534938 A/G cg18591186 chr1:62594603 INADL -0.46 -10.46 -0.38 1e-23 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 11.87 0.42 1.69e-29 Height; BRCA cis rs1163251 0.837 rs611365 chr1:120242571 C/T cg19096424 chr1:120255104 PHGDH 0.45 10.3 0.38 4.15e-23 Blood metabolite levels; BRCA cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg18132916 chr6:79620363 NA -0.42 -8.47 -0.32 1.65e-16 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.53 -0.32 1.09e-16 Electroencephalogram traits; BRCA cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg23625390 chr15:77176239 SCAPER 0.39 9.11 0.34 1.09e-18 Blood metabolite levels; BRCA cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg01802117 chr1:53393560 SCP2 0.34 7.86 0.3 1.68e-14 Monocyte count; BRCA cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.92 -0.3 1.08e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg27279351 chr12:120934652 DYNLL1 0.56 13.17 0.46 3.14e-35 High light scatter reticulocyte count; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg13047869 chr3:10149882 C3orf24 0.53 11.43 0.41 1.22e-27 Alzheimer's disease; BRCA cis rs1011018 0.628 rs61054086 chr7:139452190 A/C cg03224163 chr7:139420300 HIPK2 -0.59 -8.89 -0.33 6.11e-18 Systolic blood pressure; BRCA cis rs7246657 0.722 rs10412510 chr19:38075944 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA trans rs2727020 0.612 rs9787891 chr11:49413494 G/A cg03929089 chr4:120376271 NA -0.74 -15.94 -0.53 2.09e-48 Coronary artery disease; BRCA cis rs6546550 0.900 rs897122 chr2:70140271 C/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.93e-28 Prevalent atrial fibrillation; BRCA cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg09998033 chr7:158218633 PTPRN2 -0.41 -9.67 -0.36 9.9e-21 Obesity-related traits; BRCA cis rs6835098 0.923 rs9997477 chr4:174112543 C/T cg08422745 chr4:174089978 GALNT7 -0.75 -15.36 -0.52 1.46e-45 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs9653442 0.835 rs7565967 chr2:100744683 G/T cg07810366 chr2:100720526 AFF3 -0.32 -8.08 -0.3 3.33e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg13256891 chr4:100009986 ADH5 0.52 9.56 0.35 2.54e-20 Smoking initiation; BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA trans rs2727020 0.556 rs2866365 chr11:49390731 A/G cg15704280 chr7:45808275 SEPT13 -0.74 -15.05 -0.51 5.06e-44 Coronary artery disease; BRCA cis rs6545883 0.501 rs935860 chr2:61406561 G/C cg15711740 chr2:61764176 XPO1 -0.33 -8.25 -0.31 8.76e-16 Tuberculosis; BRCA cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg06671706 chr8:8559999 CLDN23 0.46 8.77 0.33 1.61e-17 Obesity-related traits; BRCA cis rs4423214 0.802 rs4616066 chr11:71183846 G/A cg05163923 chr11:71159392 DHCR7 -0.56 -11.35 -0.41 2.58e-27 Vitamin D levels; BRCA cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg21132104 chr15:45694354 SPATA5L1 -0.68 -14.83 -0.51 5.53e-43 Homoarginine levels; BRCA cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.83 23.35 0.68 1.22e-87 Chronic sinus infection; BRCA cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs2239547 0.523 rs6803486 chr3:53098209 T/A cg11645453 chr3:52864694 ITIH4 0.39 9.28 0.34 2.68e-19 Schizophrenia; BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg14863265 chr7:2801509 GNA12 -0.44 -9.36 -0.35 1.32e-19 Height; BRCA cis rs11583043 0.918 rs6577216 chr1:101409972 C/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.76 0.36 4.7e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs1499972 0.941 rs62264819 chr3:117671941 T/C cg07612923 chr3:117604196 NA 0.6 8.2 0.31 1.35e-15 Schizophrenia; BRCA cis rs7617773 0.780 rs11710257 chr3:48373214 T/G cg11946769 chr3:48343235 NME6 0.67 13.41 0.47 2.67e-36 Coronary artery disease; BRCA cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA trans rs1997103 1.000 rs6968966 chr7:55411356 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7617773 0.817 rs3731497 chr3:48226553 T/G cg11946769 chr3:48343235 NME6 0.65 13.59 0.47 3.98e-37 Coronary artery disease; BRCA trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg22491629 chr6:157744540 C6orf35 -0.67 -12.46 -0.44 4.53e-32 Hemostatic factors and hematological phenotypes; BRCA cis rs11608355 0.545 rs12822891 chr12:109896002 A/G cg05360138 chr12:110035743 NA 0.69 12.74 0.45 2.67e-33 Neuroticism; BRCA cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg22875332 chr1:76189707 ACADM -0.48 -9.19 -0.34 5.58e-19 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1883415 0.553 rs760907 chr6:24479873 T/C cg20631270 chr6:24437470 GPLD1 0.4 8.16 0.31 1.78e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.56 -0.44 1.72e-32 Personality dimensions; BRCA cis rs6901250 0.851 rs339307 chr6:117177340 A/G cg12892004 chr6:117198278 RFX6 -0.49 -11.41 -0.41 1.38e-27 C-reactive protein levels; BRCA cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg15352829 chr14:105391018 PLD4 -0.38 -12.42 -0.44 7.38e-32 Rheumatoid arthritis; BRCA cis rs1348850 0.519 rs1544002 chr2:178529534 C/T cg22681709 chr2:178499509 PDE11A -0.38 -8.29 -0.31 6.71e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg24692254 chr21:30365293 RNF160 -0.48 -10.56 -0.39 3.95e-24 Pancreatic cancer; BRCA cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg09658497 chr7:2847517 GNA12 -0.47 -10.49 -0.38 7.66e-24 Height; BRCA cis rs317689 0.684 rs315125 chr12:69758884 C/T cg20891283 chr12:69753455 YEATS4 0.57 11.52 0.41 5.1e-28 Response to diuretic therapy; BRCA cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2130392 1.000 rs3796689 chr4:185649866 C/A cg21366198 chr4:185655624 MLF1IP -0.39 -9.19 -0.34 5.6e-19 Kawasaki disease; BRCA cis rs1538970 0.962 rs2153609 chr1:45814058 A/G cg05343316 chr1:45956843 TESK2 0.5 10.3 0.38 3.9699999999999997e-23 Platelet count; BRCA cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg11764359 chr7:65958608 NA 0.79 19.17 0.6 4.63e-65 Aortic root size; BRCA cis rs17401966 1.000 rs12402052 chr1:10318652 C/G cg03954927 chr1:10346856 KIF1B 0.45 12.8 0.45 1.41e-33 Hepatocellular carcinoma; BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.84e-20 Tonsillectomy; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg22920501 chr2:26401640 FAM59B 0.96 16.92 0.56 2.42e-53 Gut microbiome composition (summer); BRCA cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg11644478 chr21:40555479 PSMG1 -0.68 -14.8 -0.51 8.2e-43 Cognitive function; BRCA trans rs11098499 0.865 rs3956464 chr4:120256764 T/C cg25214090 chr10:38739885 LOC399744 0.46 10.62 0.39 2.31e-24 Corneal astigmatism; BRCA cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg11266682 chr4:10021025 SLC2A9 0.48 12.82 0.45 1.26e-33 Bone mineral density; BRCA cis rs68170813 0.559 rs113422695 chr7:107070208 T/A cg02696742 chr7:106810147 HBP1 -0.51 -7.97 -0.3 7.42e-15 Coronary artery disease; BRCA cis rs6546886 0.957 rs11885172 chr2:74257094 T/C cg14702570 chr2:74259524 NA -0.3 -7.82 -0.3 2.22e-14 Dialysis-related mortality; BRCA cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg20891283 chr12:69753455 YEATS4 0.47 12.36 0.44 1.32e-31 Blood protein levels; BRCA cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.27 -0.34 2.9e-19 Alzheimer's disease (late onset); BRCA cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg08085267 chr17:45401833 C17orf57 0.6 12.3 0.44 2.38e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs58785573 0.504 rs11947292 chr4:38634749 A/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.56 12.2 0.43 6.43e-31 Lymphocyte percentage of white cells; BRCA cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg05294307 chr14:35346193 BAZ1A -0.58 -9.98 -0.37 7.07e-22 Psoriasis; BRCA cis rs477692 0.905 rs485579 chr10:131425492 T/G cg05714579 chr10:131428358 MGMT 0.59 14.57 0.5 9.89e-42 Response to temozolomide; BRCA cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg11742103 chr11:62369870 EML3;MTA2 0.49 12.3 0.44 2.45e-31 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg23708337 chr7:1209742 NA 0.59 12.86 0.45 8.27e-34 Longevity;Endometriosis; BRCA cis rs7267979 1.000 rs2482927 chr20:25327151 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.53 -0.32 1.03e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11958404 0.932 rs72816541 chr5:157414686 G/A cg05962755 chr5:157440814 NA 0.48 9.46 0.35 5.98e-20 IgG glycosylation; BRCA cis rs1891275 0.515 rs7092745 chr10:93483820 C/T cg07889827 chr10:93443413 NA -0.4 -10.83 -0.39 3.36e-25 Intelligence (multi-trait analysis); BRCA cis rs9426691 1 rs9426691 chr1:23484904 A/G cg12483005 chr1:23474871 LUZP1 0.6 12.58 0.45 1.4e-32 Coenzyme Q10 levels; BRCA cis rs950776 0.616 rs6495307 chr15:78890321 C/T cg06917634 chr15:78832804 PSMA4 0.58 12.5 0.44 3.04e-32 Sudden cardiac arrest; BRCA cis rs9818758 0.556 rs9880309 chr3:49304329 G/C cg00383909 chr3:49044727 WDR6 0.74 12.43 0.44 6.64e-32 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg20607287 chr7:12443886 VWDE -0.56 -8.48 -0.32 1.55e-16 Coronary artery disease; BRCA cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg11663144 chr21:46675770 NA -0.61 -14.22 -0.49 4.32e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg15541040 chr2:3486749 NA -0.45 -9.58 -0.35 2.06e-20 Neurofibrillary tangles; BRCA cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.36 -0.35 1.36e-19 Developmental language disorder (linguistic errors); BRCA cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg00750074 chr16:89608354 SPG7 0.34 9.11 0.34 1.02e-18 Multiple myeloma (IgH translocation); BRCA cis rs634534 0.622 rs501353 chr11:65739549 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.36 8.77 0.33 1.63e-17 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg24531977 chr5:56204891 C5orf35 0.66 13.98 0.48 5.77e-39 Initial pursuit acceleration; BRCA cis rs6426558 0.537 rs2492630 chr1:227286931 A/G cg10327440 chr1:227177885 CDC42BPA 0.48 9.44 0.35 6.63e-20 Neutrophil percentage of white cells; BRCA cis rs4805272 0.512 rs11879141 chr19:29320335 G/A cg04546413 chr19:29218101 NA 0.43 8.02 0.3 5.23e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.72 0.42 7.23e-29 Tonsillectomy; BRCA cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.47 -7.99 -0.3 6.39e-15 Mean platelet volume; BRCA cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg12463550 chr7:65579703 CRCP -0.39 -8.36 -0.31 3.99e-16 Aortic root size; BRCA cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg24642439 chr20:33292090 TP53INP2 -0.53 -11.35 -0.41 2.4200000000000002e-27 Glomerular filtration rate (creatinine); BRCA cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -9.55 -0.35 2.74e-20 Personality dimensions; BRCA cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.68 -0.32 3.26e-17 Colorectal cancer; BRCA trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.62 0.36 1.51e-20 Morning vs. evening chronotype; BRCA cis rs10193935 0.901 rs10196091 chr2:42541591 T/C cg27598129 chr2:42591480 NA -0.81 -13.14 -0.46 4.31e-35 Colonoscopy-negative controls vs population controls; BRCA cis rs4423214 0.840 rs1790341 chr11:71177578 T/C cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00166722 chr3:10149974 C3orf24 0.66 13.19 0.46 2.55e-35 Alzheimer's disease; BRCA cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg06238570 chr21:40685208 BRWD1 -0.45 -8.89 -0.33 6.42e-18 Cognitive function; BRCA trans rs7824557 0.767 rs6985460 chr8:11171087 A/C cg15556689 chr8:8085844 FLJ10661 0.36 8.68 0.32 3.33e-17 Retinal vascular caliber; BRCA cis rs9341808 0.718 rs9443735 chr6:80820474 G/T cg08355045 chr6:80787529 NA 0.37 9.38 0.35 1.13e-19 Sitting height ratio; BRCA trans rs9329221 0.527 rs6989657 chr8:10330873 C/G cg06636001 chr8:8085503 FLJ10661 0.47 9.65 0.36 1.15e-20 Neuroticism; BRCA cis rs10501293 1.000 rs1425850 chr11:43109833 T/C cg03447554 chr11:43094025 NA -0.48 -8.88 -0.33 6.85e-18 Cognitive performance; BRCA cis rs1344694 0.566 rs4672790 chr2:216892446 C/T cg12620499 chr2:216877984 MREG 0.57 14.91 0.51 2.45e-43 Alcohol dependence; BRCA trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.72 -0.36 6.22e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs11098499 0.863 rs10034450 chr4:120455649 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA trans rs3857536 0.740 rs4710571 chr6:66890250 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.54e-20 Blood trace element (Cu levels); BRCA cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg18876405 chr7:65276391 NA -0.62 -15.42 -0.52 7.35e-46 Aortic root size; BRCA cis rs490234 0.934 rs10119068 chr9:128424508 A/G cg14078157 chr9:128172775 NA -0.4 -9.2 -0.34 5.03e-19 Mean arterial pressure; BRCA cis rs9986765 0.881 rs73452602 chr7:142828331 A/T cg15652212 chr7:142981776 TMEM139 0.55 9.25 0.34 3.23e-19 Cancer;Dermatomyositis; BRCA cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg03060546 chr3:49711283 APEH 0.5 10.7 0.39 1.08e-24 Resting heart rate; BRCA trans rs1994135 0.654 rs1384591 chr12:33734170 T/C cg26384229 chr12:38710491 ALG10B 0.49 10.53 0.38 5.18e-24 Resting heart rate; BRCA cis rs17253792 0.731 rs28587929 chr14:56097492 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA trans rs12517041 0.786 rs7715927 chr5:23247790 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.4 -7.89 -0.3 1.36e-14 Calcium levels; BRCA cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg18016565 chr1:150552671 MCL1 -0.43 -10.26 -0.38 5.81e-23 Tonsillectomy; BRCA cis rs921968 0.541 rs588770 chr2:219494638 T/C cg02176678 chr2:219576539 TTLL4 0.48 12.44 0.44 5.54e-32 Mean corpuscular hemoglobin concentration; BRCA cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg01939980 chr4:1354348 KIAA1530 0.37 10.48 0.38 8.34e-24 Longevity; BRCA trans rs7647973 0.626 rs2131108 chr3:49665390 C/T cg21659725 chr3:3221576 CRBN -0.48 -8.73 -0.33 2.22e-17 Menarche (age at onset); BRCA cis rs751728 0.664 rs9394167 chr6:33754396 A/G cg25922239 chr6:33757077 LEMD2 0.49 12.55 0.44 1.92e-32 Crohn's disease; BRCA cis rs595982 0.527 rs17272673 chr19:49362992 C/A cg21252483 chr19:49399788 TULP2 -0.43 -9.4 -0.35 9.68e-20 Red cell distribution width; BRCA cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg12219531 chr12:120966889 COQ5 0.54 11.42 0.41 1.31e-27 High light scatter reticulocyte count; BRCA cis rs936229 0.749 rs4886633 chr15:75178207 G/A cg10253484 chr15:75165896 SCAMP2 -0.59 -11.45 -0.41 9.57e-28 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs9399135 0.967 rs11756988 chr6:135347595 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.41 0.44 8.13e-32 Red blood cell count; BRCA cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg26384229 chr12:38710491 ALG10B -0.65 -14.07 -0.49 2.3e-39 Heart rate; BRCA cis rs7766436 0.648 rs2876643 chr6:22591525 C/A cg13666174 chr6:22585274 NA -0.43 -10.77 -0.39 5.81e-25 Coronary artery disease; BRCA cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg26384229 chr12:38710491 ALG10B 0.81 20.23 0.62 1.02e-70 Heart rate; BRCA trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg06636001 chr8:8085503 FLJ10661 0.6 12.26 0.44 3.57e-31 Neuroticism; BRCA trans rs931812 0.895 rs965625 chr8:101909749 T/C cg20993868 chr7:22813445 NA 0.56 15.96 0.53 1.59e-48 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg18351406 chr4:77819688 ANKRD56 0.61 13.39 0.47 3.13e-36 Emphysema distribution in smoking; BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg03709012 chr19:19516395 GATAD2A 0.81 19.12 0.6 8.79e-65 Tonsillectomy; BRCA cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 4.05e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs11126340 chr2:26253255 A/G cg25036284 chr2:26402008 FAM59B -0.61 -9.87 -0.36 1.74e-21 Gut microbiome composition (summer); BRCA cis rs7647973 0.516 rs4955418 chr3:49200627 A/G cg07636037 chr3:49044803 WDR6 0.82 21.76 0.65 5.6e-79 Menarche (age at onset); BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg18402987 chr7:1209562 NA 0.84 12.05 0.43 2.8e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs478304 0.934 rs570954 chr11:65498261 A/G cg08755490 chr11:65554678 OVOL1 0.53 10.96 0.4 9.69e-26 Acne (severe); BRCA trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg03929089 chr4:120376271 NA 0.5 8.3 0.31 6.17e-16 Axial length; BRCA cis rs847577 0.748 rs940431 chr7:97716495 C/T cg21770322 chr7:97807741 LMTK2 0.58 16.99 0.56 1.12e-53 Breast cancer; BRCA cis rs7592578 0.771 rs12052514 chr2:191378170 C/T cg10560079 chr2:191398806 TMEM194B -0.69 -12.97 -0.46 2.47e-34 Diastolic blood pressure; BRCA trans rs9393777 0.920 rs13196692 chr6:27379119 C/T cg01620082 chr3:125678407 NA -0.85 -10.28 -0.38 4.85e-23 Intelligence (multi-trait analysis); BRCA trans rs7824557 0.734 rs2293856 chr8:11177447 C/T cg08975724 chr8:8085496 FLJ10661 0.44 8.11 0.31 2.53e-15 Retinal vascular caliber; BRCA cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg24634471 chr8:143751801 JRK 0.42 8.83 0.33 9.89e-18 Schizophrenia; BRCA cis rs11098499 0.754 rs7689729 chr4:120256192 A/G cg09307838 chr4:120376055 NA 0.63 13.65 0.48 2.17e-37 Corneal astigmatism; BRCA cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg10932868 chr11:921992 NA 0.39 9.55 0.35 2.82e-20 Alzheimer's disease (late onset); BRCA cis rs2130392 0.926 rs4610379 chr4:185624388 A/G cg04058563 chr4:185651563 MLF1IP 0.32 7.94 0.3 8.9e-15 Kawasaki disease; BRCA cis rs7575873 1 rs7575873 chr2:23962647 A/G cg20701182 chr2:24300061 SF3B14 0.66 9.46 0.35 5.67e-20 Birth weight; BRCA cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA cis rs3820928 0.874 rs13423046 chr2:227901805 G/T cg11843606 chr2:227700838 RHBDD1 -0.36 -7.91 -0.3 1.16e-14 Pulmonary function; BRCA cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg21770322 chr7:97807741 LMTK2 0.41 10.95 0.4 1.04e-25 Prostate cancer (SNP x SNP interaction); BRCA trans rs11976180 1.000 rs1919948 chr7:143762843 T/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.79 18.8 0.6 4.08e-63 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg08280861 chr8:58055591 NA 0.53 8.52 0.32 1.16e-16 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg04455712 chr21:45112962 RRP1B -0.42 -10.8 -0.39 4.19e-25 Mean corpuscular volume; BRCA cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg24812749 chr6:127587940 RNF146 0.69 15.11 0.51 2.58e-44 Breast cancer; BRCA cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg06026331 chr20:60912101 LAMA5 -0.64 -13.04 -0.46 1.31e-34 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs7589728 1.000 rs6722069 chr2:88533151 C/T cg04511125 chr2:88470314 THNSL2 0.69 10.2 0.37 1.01e-22 Plasma clusterin levels; BRCA cis rs7527798 0.592 rs11118345 chr1:207854827 A/T cg21110645 chr1:207815933 NA -0.28 -7.84 -0.3 1.92e-14 Erythrocyte sedimentation rate; BRCA cis rs9463078 0.547 rs4449629 chr6:44717808 T/C cg25276700 chr6:44698697 NA 0.37 8.57 0.32 7.53e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg08564027 chr20:61660810 NA 0.84 22.78 0.67 1.49e-84 Prostate cancer (SNP x SNP interaction); BRCA trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg23533926 chr12:111358616 MYL2 -0.43 -8.97 -0.33 3.19e-18 Extrinsic epigenetic age acceleration; BRCA cis rs1153858 1.000 rs11858495 chr15:45637662 A/G cg21132104 chr15:45694354 SPATA5L1 -0.7 -15.41 -0.52 8.32e-46 Homoarginine levels; BRCA cis rs6963495 0.745 rs73190179 chr7:105162812 C/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs2425143 0.730 rs7263640 chr20:34314725 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08109568 chr15:31115862 NA -0.45 -10.64 -0.39 1.84e-24 Huntington's disease progression; BRCA cis rs4481887 0.927 rs4916087 chr1:248493833 T/C cg00666640 chr1:248458726 OR2T12 0.33 8.99 0.34 2.75e-18 Common traits (Other); BRCA cis rs9467773 0.620 rs1027203 chr6:26639332 G/C cg11502198 chr6:26597334 ABT1 0.48 9.45 0.35 6.1e-20 Intelligence (multi-trait analysis); BRCA cis rs9467773 1.000 rs6910899 chr6:26524339 A/G cg09904177 chr6:26538194 HMGN4 0.57 18.5 0.59 1.62e-61 Intelligence (multi-trait analysis); BRCA cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg26031613 chr14:104095156 KLC1 -0.45 -8.62 -0.32 5.24e-17 Schizophrenia; BRCA cis rs1003719 0.667 rs73201942 chr21:38475164 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.51 10.89 0.4 1.92e-25 Eye color traits; BRCA cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg11764359 chr7:65958608 NA 0.71 16.0 0.53 1e-48 Aortic root size; BRCA cis rs17023223 0.537 rs10923766 chr1:119726932 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs3784262 0.669 rs34226780 chr15:58280168 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.04 -0.37 3.94e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2046867 0.818 rs6808341 chr3:72914847 A/G cg25664220 chr3:72788482 NA -0.4 -9.29 -0.35 2.3e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg11764359 chr7:65958608 NA -0.79 -19.23 -0.61 2.32e-65 Aortic root size; BRCA cis rs1865721 0.958 rs11663060 chr18:73172806 T/C cg26385618 chr18:73139727 C18orf62 -0.39 -9.0 -0.34 2.6e-18 Intelligence; BRCA cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg24324837 chr19:49891574 CCDC155 0.48 8.23 0.31 1.03e-15 Multiple sclerosis; BRCA cis rs7707921 0.705 rs226194 chr5:81585026 G/T cg15871215 chr5:81402204 ATG10 0.35 8.25 0.31 8.86e-16 Breast cancer; BRCA cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg18252515 chr7:66147081 NA -0.56 -11.25 -0.41 6.39e-27 Corneal structure; BRCA cis rs9399135 0.967 rs6923765 chr6:135335176 C/G cg24558204 chr6:135376177 HBS1L -0.45 -11.86 -0.42 1.78e-29 Red blood cell count; BRCA cis rs2011503 1.000 rs16996127 chr19:19627310 T/G cg11584989 chr19:19387371 SF4 0.5 11.16 0.4 1.47e-26 Bipolar disorder; BRCA cis rs6138458 0.743 rs3746330 chr20:24999795 A/G cg26195577 chr20:24973756 C20orf3 0.64 15.71 0.53 2.74e-47 Blood protein levels; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg03116740 chr11:841335 TSPAN4;POLR2L -0.37 -8.12 -0.31 2.41e-15 Mean platelet volume; BRCA cis rs9790314 0.613 rs1447620 chr3:160616211 T/C cg03342759 chr3:160939853 NMD3 0.43 8.56 0.32 8.3e-17 Morning vs. evening chronotype; BRCA cis rs66887589 0.627 rs3872807 chr4:120360251 T/A cg09307838 chr4:120376055 NA 0.48 9.96 0.37 8.35e-22 Diastolic blood pressure; BRCA cis rs7520050 0.966 rs785481 chr1:46554518 G/A cg24296786 chr1:45957014 TESK2 0.41 9.21 0.34 4.54e-19 Red blood cell count;Reticulocyte count; BRCA cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg11584989 chr19:19387371 SF4 0.6 13.67 0.48 1.66e-37 Bipolar disorder; BRCA cis rs7246657 0.525 rs1667359 chr19:37486172 G/A cg23950597 chr19:37808831 NA -0.52 -8.28 -0.31 7.37e-16 Coronary artery calcification; BRCA cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg24879335 chr3:133465180 TF 0.33 11.11 0.4 2.36e-26 Iron status biomarkers (transferrin levels); BRCA cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg26384229 chr12:38710491 ALG10B 0.75 17.0 0.56 9.05e-54 Bladder cancer; BRCA cis rs2859741 0.565 rs12023397 chr1:37507739 G/A cg09363841 chr1:37513479 NA -0.54 -11.77 -0.42 4.55e-29 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs694739 0.628 rs538147 chr11:64129722 G/A cg02228329 chr11:64053129 BAD;GPR137 0.53 11.72 0.42 7.16e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg26031613 chr14:104095156 KLC1 0.77 16.65 0.55 5.89e-52 Body mass index; BRCA cis rs8017423 0.647 rs4904674 chr14:90817412 G/A cg04374321 chr14:90722782 PSMC1 -0.5 -11.99 -0.43 5.23e-30 Mortality in heart failure; BRCA cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs921968 0.541 rs6717433 chr2:219375711 G/C cg02176678 chr2:219576539 TTLL4 -0.54 -13.52 -0.47 8.18e-37 Mean corpuscular hemoglobin concentration; BRCA cis rs1200821 0.529 rs2505707 chr10:37801254 T/C cg25427524 chr10:38739819 LOC399744 -0.42 -8.89 -0.33 6.26e-18 Hemostatic factors and hematological phenotypes; BRCA cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg12373951 chr3:133503437 NA 0.33 7.97 0.3 7.11e-15 Iron status biomarkers; BRCA trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg01620082 chr3:125678407 NA -0.74 -9.14 -0.34 8.09e-19 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Menopause (age at onset); BRCA cis rs13095912 1.000 rs6784842 chr3:185342723 C/T cg11274856 chr3:185301563 NA 0.33 8.26 0.31 8.26e-16 Systolic blood pressure; BRCA cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg09580153 chr6:41068724 NFYA;LOC221442 0.38 8.27 0.31 7.81e-16 Alzheimer's disease (late onset); BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg02951883 chr7:2050386 MAD1L1 -0.38 -9.02 -0.34 2.26e-18 Bipolar disorder and schizophrenia; BRCA cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg01689657 chr7:91764605 CYP51A1 0.23 8.31 0.31 5.54e-16 Breast cancer; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg23131131 chr22:24373011 LOC391322 -0.46 -11.02 -0.4 5.69e-26 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17253792 0.822 rs75897560 chr14:56090965 C/T cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.73 -0.42 6.2e-29 Chronic sinus infection; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg04518342 chr5:131593106 PDLIM4 0.42 10.1 0.37 2.41e-22 Acylcarnitine levels; BRCA trans rs8062405 0.824 rs62034324 chr16:28536762 T/C cg09719594 chr16:21412588 NA -0.35 -8.36 -0.31 3.87e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs72960926 0.744 rs2351778 chr6:74866814 T/G cg03266952 chr6:74778945 NA -0.67 -8.02 -0.3 5.06e-15 Metabolite levels (MHPG); BRCA cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg13319975 chr6:146136371 FBXO30 -0.42 -9.71 -0.36 7.12e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg26750617 chr12:132293702 NA -0.43 -9.61 -0.36 1.69e-20 Migraine; BRCA cis rs965469 1.000 rs6051810 chr20:3355384 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.49 -0.38 7.39e-24 IFN-related cytopenia; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg18402987 chr7:1209562 NA 0.9 14.51 0.5 1.95e-41 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11677370 0.574 rs12329183 chr2:3866943 G/A cg17052675 chr2:3827356 NA -0.51 -11.38 -0.41 1.86e-27 Type 2 diabetes; BRCA cis rs6750047 0.605 rs2121260 chr2:38268763 T/G cg07380506 chr2:38303506 CYP1B1 0.47 10.11 0.37 2.22e-22 Cutaneous malignant melanoma;Melanoma; BRCA trans rs11098499 0.754 rs66900435 chr4:120249425 C/A cg25214090 chr10:38739885 LOC399744 0.46 10.53 0.38 4.92e-24 Corneal astigmatism; BRCA cis rs9300255 0.602 rs10744147 chr12:123643729 A/G cg00376283 chr12:123451042 ABCB9 0.51 11.15 0.4 1.63e-26 Neutrophil percentage of white cells; BRCA cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.23 0.31 1.06e-15 Cognitive ability; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.11 -0.43 1.57e-30 Alzheimer's disease; BRCA cis rs61990749 0.597 rs1008988 chr14:78260795 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.25 0.38 6.39e-23 Fibroblast growth factor basic levels; BRCA cis rs6973256 0.605 rs13237435 chr7:133347570 C/T cg07491979 chr7:133331646 EXOC4 -0.34 -7.82 -0.3 2.17e-14 Intelligence (multi-trait analysis); BRCA cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.44 8.6 0.32 6.03e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.37e-15 Menopause (age at onset); BRCA cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.28 -0.44 2.79e-31 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 14.28 0.49 2.44e-40 Alzheimer's disease; BRCA cis rs10056811 0.538 rs4632781 chr5:74376658 G/C cg19683494 chr5:74908142 NA 0.56 8.32 0.31 5.39e-16 Coronary artery disease; BRCA cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg00530320 chr1:46809349 NSUN4 0.49 9.7 0.36 7.91e-21 Menopause (age at onset); BRCA cis rs9486715 0.838 rs9320127 chr6:96865358 G/A cg06623918 chr6:96969491 KIAA0776 0.86 23.87 0.69 1.55e-90 Headache; BRCA cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.53 12.1 0.43 1.79e-30 Colorectal cancer; BRCA cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg08873628 chr1:175162347 KIAA0040 -0.34 -8.13 -0.31 2.3e-15 Diastolic blood pressure; BRCA cis rs9807989 0.507 rs7605284 chr2:103044175 T/G cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma; BRCA cis rs10751667 0.643 rs12278229 chr11:946985 A/G ch.11.42038R chr11:967971 AP2A2 0.49 15.53 0.52 2.31e-46 Alzheimer's disease (late onset); BRCA cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg17724175 chr1:150552817 MCL1 -0.24 -8.05 -0.3 3.99e-15 Tonsillectomy; BRCA trans rs9858542 0.953 rs9837027 chr3:49597013 C/T cg21659725 chr3:3221576 CRBN -0.46 -10.22 -0.37 8.57e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg11843238 chr5:131593191 PDLIM4 0.35 9.03 0.34 1.93e-18 Breast cancer; BRCA trans rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg11812906 chr14:75593930 NEK9 -0.59 -13.06 -0.46 9.96e-35 Height; BRCA cis rs965469 0.895 rs6037592 chr20:3392950 T/G cg25506879 chr20:3388711 C20orf194 -0.51 -10.0 -0.37 5.6e-22 IFN-related cytopenia; BRCA cis rs4919694 1.000 rs11191445 chr10:104651055 C/T cg04362960 chr10:104952993 NT5C2 0.95 14.86 0.51 4.07e-43 Arsenic metabolism; BRCA cis rs6545883 0.929 rs6707830 chr2:61749472 G/A cg15711740 chr2:61764176 XPO1 -0.52 -13.17 -0.46 3.39e-35 Tuberculosis; BRCA cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -13.45 -0.47 1.81e-36 Bone mineral density; BRCA cis rs7927771 0.524 rs10838774 chr11:47856114 A/G cg20307385 chr11:47447363 PSMC3 0.44 10.09 0.37 2.65e-22 Subjective well-being; BRCA cis rs4974559 0.947 rs12639938 chr4:1343135 G/C cg02980000 chr4:1222292 CTBP1 0.76 12.89 0.45 5.61e-34 Systolic blood pressure; BRCA cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg24642439 chr20:33292090 TP53INP2 0.56 12.22 0.44 5.09e-31 Coronary artery disease; BRCA cis rs208346 1.000 rs208346 chr7:2799686 G/T cg18446336 chr7:2847575 GNA12 0.36 8.57 0.32 7.8e-17 Loneliness (linear analysis); BRCA cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 21.17 0.64 8.76e-76 Smoking behavior; BRCA cis rs73001065 0.636 rs10415849 chr19:19505087 C/T cg03709012 chr19:19516395 GATAD2A 1.0 14.91 0.51 2.29e-43 LDL cholesterol; BRCA cis rs10927875 0.541 rs1763601 chr1:16340460 G/T cg22431228 chr1:16359049 CLCNKA -0.43 -9.71 -0.36 6.72e-21 Dilated cardiomyopathy; BRCA cis rs965469 1.000 rs6133036 chr20:3349682 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.54 -0.38 4.61e-24 IFN-related cytopenia; BRCA cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg00677455 chr12:58241039 CTDSP2 -0.35 -7.88 -0.3 1.46e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg21573476 chr21:45109991 RRP1B -0.33 -8.55 -0.32 8.92e-17 Mean corpuscular volume; BRCA cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 3.74e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.14 0.34 8.5e-19 Systemic lupus erythematosus; BRCA cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg25358565 chr5:93447407 FAM172A 1.17 18.44 0.59 3.18e-61 Diabetic retinopathy; BRCA cis rs274567 0.550 rs272885 chr5:131667736 A/G cg07395648 chr5:131743802 NA -0.35 -7.86 -0.3 1.58e-14 Blood metabolite levels; BRCA cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg16931447 chr4:875861 GAK -0.37 -8.45 -0.32 2e-16 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; BRCA cis rs912057 0.833 rs1294424 chr6:6744135 G/A cg06612196 chr6:6737390 NA 0.39 8.72 0.33 2.31e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs11711311 1.000 rs13070720 chr3:113473754 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.33 0.35 1.72e-19 IgG glycosylation; BRCA cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg11843238 chr5:131593191 PDLIM4 0.32 7.81 0.3 2.29e-14 Blood metabolite levels; BRCA cis rs4900538 0.963 rs1885708 chr14:102960164 A/G cg18135206 chr14:102964638 TECPR2 1.05 29.55 0.76 1.18e-121 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg24558204 chr6:135376177 HBS1L 0.59 15.99 0.53 1.14e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg02659138 chr7:134003124 SLC35B4 0.32 9.8 0.36 3.24e-21 Mean platelet volume; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.73 -15.81 -0.53 9.55e-48 Lymphocyte counts; BRCA cis rs7481584 0.564 rs432585 chr11:3084903 G/A cg08508325 chr11:3079039 CARS 0.3 8.89 0.33 6.18e-18 Calcium levels; BRCA cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg12310025 chr6:25882481 NA -0.52 -11.54 -0.42 4.14e-28 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs62271514 chr3:134298554 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.69 0.33 2.92e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg14926445 chr8:58193284 C8orf71 -0.47 -8.83 -0.33 9.87e-18 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.21 0.46 2.03e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10465746 0.780 rs4907190 chr1:84409168 T/C cg10977910 chr1:84465055 TTLL7 0.56 11.77 0.42 4.52e-29 Obesity-related traits; BRCA cis rs9467773 0.967 rs6924865 chr6:26521353 A/G cg11502198 chr6:26597334 ABT1 0.5 9.91 0.36 1.29e-21 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.23 0.31 1.09e-15 Menopause (age at onset); BRCA cis rs999943 0.846 rs2274200 chr6:33625696 T/C cg14003231 chr6:33640908 ITPR3 0.68 15.46 0.52 4.92e-46 Obesity (extreme); BRCA cis rs4891159 0.548 rs654754 chr18:74143695 T/C cg24786174 chr18:74118243 ZNF516 0.8 23.43 0.68 4.11e-88 Longevity; BRCA cis rs7264396 0.561 rs2064725 chr20:34569142 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -9.73 -0.36 6.04e-21 Total cholesterol levels; BRCA cis rs10193935 0.901 rs10171643 chr2:42532912 C/T cg27598129 chr2:42591480 NA -0.8 -12.32 -0.44 1.98e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs4478858 0.806 rs6686845 chr1:31708796 A/T cg00250761 chr1:31883323 NA -0.33 -8.56 -0.32 8.52e-17 Alcohol dependence; BRCA cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg26395211 chr5:140044315 WDR55 -0.38 -8.77 -0.33 1.62e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg21248554 chr2:27665150 KRTCAP3 -0.34 -8.57 -0.32 7.47e-17 Total body bone mineral density; BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg12444411 chr7:2802554 GNA12 -0.38 -9.5 -0.35 4.01e-20 Height; BRCA cis rs3125734 0.608 rs7094950 chr10:64019744 T/C cg09941381 chr10:64027924 RTKN2 -0.28 -8.12 -0.31 2.33e-15 Rheumatoid arthritis; BRCA cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs796364 0.789 rs1653297 chr2:201075483 C/T cg23649088 chr2:200775458 C2orf69 0.61 11.87 0.43 1.63e-29 Schizophrenia; BRCA cis rs2880765 0.835 rs11074276 chr15:86030363 C/A cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.27e-17 Coronary artery disease; BRCA cis rs17253792 0.545 rs34446601 chr14:56010586 A/G cg01858014 chr14:56050164 KTN1 -0.61 -7.83 -0.3 1.99e-14 Putamen volume; BRCA cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg10560079 chr2:191398806 TMEM194B 0.36 8.2 0.31 1.31e-15 Pulse pressure; BRCA cis rs9467773 0.620 rs2494700 chr6:26631306 C/T cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.68e-30 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg04025307 chr7:1156635 C7orf50 0.72 17.91 0.58 1.88e-58 Longevity;Endometriosis; BRCA cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg01877450 chr7:97915802 BRI3 -0.37 -8.33 -0.31 4.82e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs8014204 0.762 rs8016389 chr14:75287554 T/C cg06637938 chr14:75390232 RPS6KL1 0.44 9.06 0.34 1.62e-18 Caffeine consumption; BRCA cis rs4906332 1.000 rs2065015 chr14:103904061 G/T cg04998671 chr14:104000505 TRMT61A 0.43 9.4 0.35 9.86e-20 Coronary artery disease; BRCA cis rs9399135 0.904 rs4895438 chr6:135317665 G/T cg24558204 chr6:135376177 HBS1L 0.45 12.29 0.44 2.57e-31 Red blood cell count; BRCA cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg17211192 chr8:82754475 SNX16 0.61 11.71 0.42 7.86e-29 Diastolic blood pressure; BRCA cis rs10227331 0.846 rs12673606 chr7:157297518 C/G cg04156418 chr7:157293606 NA 0.38 10.78 0.39 5.21e-25 Inattentive symptoms; BRCA cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.32 -0.44 1.93e-31 Bipolar disorder; BRCA cis rs853679 0.517 rs9380047 chr6:28037893 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.2 -0.31 1.31e-15 Depression; BRCA cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.83e-31 Blood protein levels; BRCA cis rs2882667 0.690 rs288036 chr5:138210895 C/A cg04439458 chr5:138467593 SIL1 -0.35 -8.55 -0.32 9.12e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9296092 0.560 rs62407561 chr6:33528103 T/C cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA trans rs57221529 0.766 rs72706610 chr5:561111 G/A cg25482853 chr8:67687455 SGK3 1.03 17.7 0.57 2.42e-57 Lung disease severity in cystic fibrosis; BRCA cis rs7246657 0.765 rs7247259 chr19:37851090 T/C cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs9790314 1.000 rs7653361 chr3:160992291 C/T cg04691961 chr3:161091175 C3orf57 -0.59 -14.13 -0.49 1.19e-39 Morning vs. evening chronotype; BRCA cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg21017887 chr14:105400489 NA 0.66 17.5 0.57 2.47e-56 Rheumatoid arthritis; BRCA cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg27121462 chr16:89883253 FANCA -0.58 -13.63 -0.47 2.47e-37 Vitiligo; BRCA cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.41 0.54 8.87e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg25036284 chr2:26402008 FAM59B -0.9 -15.25 -0.52 5.07e-45 Gut microbiome composition (summer); BRCA cis rs1538970 0.962 rs9429076 chr1:45819489 A/G cg05343316 chr1:45956843 TESK2 0.41 7.85 0.3 1.7e-14 Platelet count; BRCA cis rs7617773 0.539 rs13087050 chr3:48392800 C/T cg11946769 chr3:48343235 NME6 0.45 9.69 0.36 8.34e-21 Coronary artery disease; BRCA cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg05347473 chr6:146136440 FBXO30 -0.42 -8.53 -0.32 1.03e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg00531865 chr16:30841666 NA -0.5 -11.54 -0.42 4.12e-28 Multiple myeloma; BRCA cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.51 9.7 0.36 7.89e-21 Aortic root size; BRCA cis rs6748734 0.779 rs4401206 chr2:241796905 A/G cg02820040 chr2:241836501 C2orf54 -0.47 -9.15 -0.34 7.58e-19 Urinary metabolites; BRCA cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg05283184 chr6:79620031 NA -0.43 -10.94 -0.4 1.23e-25 Intelligence (multi-trait analysis); BRCA cis rs701145 0.585 rs1727880 chr3:153835972 G/A cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.89e-18 Coronary artery disease; BRCA cis rs8072100 0.934 rs9905583 chr17:45741016 C/T cg08085267 chr17:45401833 C17orf57 -0.67 -14.76 -0.5 1.29e-42 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12618769 0.570 rs116051325 chr2:99056836 G/A cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg06618935 chr21:46677482 NA -0.38 -8.39 -0.32 3.11e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1801251 1.000 rs35085837 chr2:233624363 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.42 0.41 1.32e-27 Coronary artery disease; BRCA cis rs2806561 0.894 rs628106 chr1:23537685 C/T cg19743168 chr1:23544995 NA 0.47 11.77 0.42 4.24e-29 Height; BRCA cis rs7737355 0.947 rs7725220 chr5:130877001 C/G cg06307176 chr5:131281290 NA 0.54 10.68 0.39 1.3e-24 Life satisfaction; BRCA cis rs875971 0.545 rs73136346 chr7:65566082 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.39 -0.38 1.8e-23 Aortic root size; BRCA cis rs7412746 0.611 rs2864873 chr1:150814174 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.83 0.3 2.11e-14 Melanoma; BRCA cis rs2637030 0.559 rs256110 chr5:52879803 A/G cg06476337 chr5:52856530 NDUFS4 0.36 8.13 0.31 2.23e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg00071950 chr4:10020882 SLC2A9 0.55 13.57 0.47 4.91e-37 Bone mineral density; BRCA cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg15212455 chr7:39170539 POU6F2 0.39 8.77 0.33 1.66e-17 IgG glycosylation; BRCA cis rs9486719 0.947 rs2499801 chr6:96854594 G/A cg06623918 chr6:96969491 KIAA0776 0.74 12.81 0.45 1.39e-33 Migraine;Coronary artery disease; BRCA cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg04450456 chr4:17643702 FAM184B 0.38 11.11 0.4 2.49e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg14349672 chr11:133703707 NA -0.42 -9.53 -0.35 3.35e-20 Childhood ear infection; BRCA cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg08999081 chr20:33150536 PIGU 0.36 9.21 0.34 4.44e-19 Coronary artery disease; BRCA cis rs801193 0.569 rs10950050 chr7:66239588 A/C cg18876405 chr7:65276391 NA 0.47 10.6 0.39 2.68e-24 Aortic root size; BRCA cis rs11229555 0.645 rs12785578 chr11:58206432 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg15145296 chr3:125709740 NA -0.55 -8.65 -0.32 4.23e-17 Blood pressure (smoking interaction); BRCA cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg17971929 chr21:40555470 PSMG1 -0.78 -18.15 -0.58 1.04e-59 Cognitive function; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg23708337 chr7:1209742 NA 0.63 8.84 0.33 9.2e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg15704280 chr7:45808275 SEPT13 0.51 8.72 0.33 2.4e-17 Axial length; BRCA cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.39 0.32 3.01e-16 Mean platelet volume; BRCA cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs9811920 0.809 rs4928153 chr3:99808445 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.53 -12.87 -0.45 7.45e-34 Axial length; BRCA cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11890956 chr21:40555474 PSMG1 1.04 28.62 0.75 1.45e-116 Cognitive function; BRCA cis rs72634258 0.554 rs17374292 chr1:7881234 C/T cg26816564 chr1:7831052 VAMP3 0.67 12.44 0.44 5.76e-32 Inflammatory bowel disease; BRCA cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg17366294 chr4:99064904 C4orf37 0.43 9.78 0.36 3.98e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs367943 0.966 rs364738 chr5:112808329 A/G cg12552261 chr5:112820674 MCC -0.55 -12.22 -0.44 4.98e-31 Type 2 diabetes; BRCA cis rs10754283 0.967 rs10801761 chr1:90115269 C/T cg21401794 chr1:90099060 LRRC8C 0.45 10.94 0.4 1.2e-25 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs10464366 0.519 rs6974609 chr7:39219149 C/T cg15212455 chr7:39170539 POU6F2 0.39 8.65 0.32 4.22e-17 IgG glycosylation; BRCA cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.5 10.17 0.37 1.31e-22 Hip circumference adjusted for BMI; BRCA cis rs4664304 0.620 rs2048437 chr2:160712065 C/T cg01092293 chr2:160761427 LY75 0.36 8.52 0.32 1.14e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg09877947 chr5:131593287 PDLIM4 0.38 9.54 0.35 2.98e-20 Breast cancer; BRCA cis rs644148 0.902 rs12982159 chr19:44964300 C/T cg15540054 chr19:45004280 ZNF180 -0.56 -11.68 -0.42 1.05e-28 Personality dimensions; BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.91 0.6 1.2e-63 Tonsillectomy; BRCA cis rs6901250 0.744 rs636872 chr6:117087944 C/T cg12892004 chr6:117198278 RFX6 0.45 10.54 0.38 4.53e-24 C-reactive protein levels; BRCA cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg05623727 chr3:50126028 RBM5 0.5 12.37 0.44 1.16e-31 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg06494592 chr3:125709126 NA -0.53 -8.22 -0.31 1.17e-15 Blood pressure (smoking interaction); BRCA cis rs9318086 0.753 rs9553094 chr13:24474613 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.31 -8.77 -0.33 1.66e-17 Myopia (pathological); BRCA cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.42e-34 Alzheimer's disease (late onset); BRCA cis rs6546537 0.562 rs1985342 chr2:69758927 C/T cg10773587 chr2:69614142 GFPT1 -0.37 -8.34 -0.31 4.45e-16 Serum thyroid-stimulating hormone levels; BRCA cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg17294928 chr15:75287854 SCAMP5 0.75 15.93 0.53 2.42e-48 Blood trace element (Zn levels); BRCA cis rs7586879 0.789 rs17046737 chr2:25127835 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.48 0.35 4.99e-20 Body mass index; BRCA cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg23711669 chr6:146136114 FBXO30 0.72 17.08 0.56 3.73e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6087990 0.735 rs1040555 chr20:31380201 A/T cg13636640 chr20:31349939 DNMT3B -0.61 -17.72 -0.57 1.91e-57 Ulcerative colitis; BRCA trans rs9393777 0.920 rs13196692 chr6:27379119 C/T cg06606381 chr12:133084897 FBRSL1 -0.77 -8.15 -0.31 1.98e-15 Intelligence (multi-trait analysis); BRCA cis rs3925075 0.531 rs4594268 chr16:31343243 T/C cg02846316 chr16:31340340 ITGAM 0.43 8.73 0.33 2.22e-17 IgA nephropathy; BRCA cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 12.07 0.43 2.33e-30 Tonsillectomy; BRCA cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs1577917 0.655 rs9359658 chr6:86305769 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.31 8.61 0.32 5.48e-17 Response to antipsychotic treatment; BRCA cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg21782813 chr7:2030301 MAD1L1 0.4 10.77 0.39 5.85e-25 Bipolar disorder and schizophrenia; BRCA cis rs7927771 0.524 rs4539273 chr11:47694699 C/T cg20307385 chr11:47447363 PSMC3 -0.39 -9.08 -0.34 1.32e-18 Subjective well-being; BRCA cis rs332507 0.830 rs2173852 chr3:124420102 C/G cg05980111 chr3:124395277 KALRN -0.33 -7.85 -0.3 1.7e-14 Plateletcrit; BRCA cis rs870825 0.929 rs55635512 chr4:185589982 G/T cg04058563 chr4:185651563 MLF1IP 0.69 11.73 0.42 6.4e-29 Blood protein levels; BRCA cis rs11690935 0.595 rs788166 chr2:172915489 G/C cg13550731 chr2:172543902 DYNC1I2 0.56 14.24 0.49 3.61e-40 Schizophrenia; BRCA cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg00701064 chr4:6280414 WFS1 0.68 17.62 0.57 5.86e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg00677455 chr12:58241039 CTDSP2 0.63 14.53 0.5 1.61e-41 Multiple sclerosis; BRCA cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg25173405 chr17:45401733 C17orf57 -0.51 -10.59 -0.39 2.89e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7582180 0.629 rs74177696 chr2:100938481 C/G cg14675211 chr2:100938903 LONRF2 0.52 11.65 0.42 1.41e-28 Intelligence (multi-trait analysis); BRCA cis rs7103648 1.000 rs11039225 chr11:47430599 G/A cg20307385 chr11:47447363 PSMC3 0.87 26.56 0.72 2.59e-105 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9486719 1.000 rs4078038 chr6:96904366 A/G cg06623918 chr6:96969491 KIAA0776 -0.71 -12.76 -0.45 2.19e-33 Migraine;Coronary artery disease; BRCA trans rs1973993 0.662 rs2057427 chr1:96888897 C/G cg10631902 chr5:14652156 NA -0.45 -12.41 -0.44 7.5e-32 Weight; BRCA cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.97e-15 Breast cancer; BRCA cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 6.53e-87 Chronic sinus infection; BRCA cis rs13064411 0.696 rs2129434 chr3:113138763 A/C cg18753928 chr3:113234510 CCDC52 -0.49 -9.38 -0.35 1.1e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA trans rs7618501 0.699 rs9821675 chr3:49902544 A/G cg21659725 chr3:3221576 CRBN 0.51 13.15 0.46 3.86e-35 Intelligence (multi-trait analysis); BRCA cis rs9807989 0.524 rs4851576 chr2:103028895 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma; BRCA cis rs6570726 0.764 rs9322028 chr6:145895797 G/T cg23711669 chr6:146136114 FBXO30 0.74 17.75 0.57 1.29e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs490234 0.902 rs12351538 chr9:128281503 A/G cg14078157 chr9:128172775 NA -0.33 -7.83 -0.3 1.96e-14 Mean arterial pressure; BRCA cis rs2239547 0.618 rs1573815 chr3:52870132 A/G cg18404041 chr3:52824283 ITIH1 0.32 8.51 0.32 1.26e-16 Schizophrenia; BRCA cis rs11958404 0.789 rs72818150 chr5:157484121 A/G cg05962755 chr5:157440814 NA 0.55 9.68 0.36 8.67e-21 IgG glycosylation; BRCA cis rs7809615 0.901 rs6947941 chr7:99156446 G/T cg12290671 chr7:99195819 NA -0.5 -8.44 -0.32 2.2e-16 Blood metabolite ratios; BRCA cis rs9787249 0.957 rs11809515 chr1:40205326 C/A cg02773041 chr1:40204384 PPIE 0.45 9.68 0.36 8.97e-21 Blood protein levels; BRCA cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.55 0.32 9.33e-17 Electroencephalogram traits; BRCA cis rs12681288 0.823 rs2701903 chr8:1004029 A/G cg04851639 chr8:1020857 NA 0.33 10.29 0.38 4.36e-23 Schizophrenia; BRCA cis rs992157 0.798 rs1017698 chr2:219170525 A/G cg00012203 chr2:219082015 ARPC2 -0.5 -10.2 -0.37 9.7e-23 Colorectal cancer; BRCA trans rs7746199 0.736 rs56405707 chr6:27640246 G/A cg06606381 chr12:133084897 FBRSL1 -0.86 -8.5 -0.32 1.31e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg03188948 chr7:1209495 NA 0.61 11.6 0.42 2.3e-28 Longevity;Endometriosis; BRCA cis rs6496044 0.568 rs7176291 chr15:86067398 T/C cg10818794 chr15:86012489 AKAP13 -0.29 -7.91 -0.3 1.18e-14 Interstitial lung disease; BRCA cis rs4664304 0.772 rs12692572 chr2:160743793 G/A cg02280532 chr2:160761244 LY75 0.36 7.98 0.3 6.9e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.25 0.38 6.57e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg12386194 chr3:101231763 SENP7 0.47 9.83 0.36 2.59e-21 Colorectal cancer; BRCA cis rs2239547 0.563 rs6797399 chr3:52905917 G/A cg18404041 chr3:52824283 ITIH1 -0.31 -7.83 -0.3 2.02e-14 Schizophrenia; BRCA cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.72 -0.39 9.09e-25 Mean corpuscular volume; BRCA cis rs1577917 0.837 rs806529 chr6:86467121 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -8.08 -0.3 3.15e-15 Response to antipsychotic treatment; BRCA cis rs698813 0.674 rs713447 chr2:44505185 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.54 9.27 0.34 2.85e-19 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs2549003 0.966 rs10213701 chr5:131824064 T/A cg02551604 chr5:131831745 NA -0.4 -14.07 -0.49 2.23e-39 Asthma (sex interaction); BRCA trans rs877282 1.000 rs11253369 chr10:773610 C/G cg22713356 chr15:30763199 NA 1.03 19.89 0.62 7.27e-69 Uric acid levels; BRCA cis rs9287719 0.967 rs6750891 chr2:10738563 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg12311346 chr5:56204834 C5orf35 -0.73 -11.77 -0.42 4.34e-29 Type 2 diabetes; BRCA cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.14 0.43 1.1e-30 Tonsillectomy; BRCA cis rs6543140 0.601 rs6543135 chr2:103062406 C/T cg04239558 chr2:103089729 SLC9A4 0.34 8.1 0.31 2.71e-15 Blood protein levels; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.67 14.34 0.49 1.18e-40 Lymphocyte counts; BRCA cis rs3768617 0.811 rs12120747 chr1:183042531 G/A ch.1.3577855R chr1:183094577 LAMC1 0.45 9.63 0.36 1.34e-20 Fuchs's corneal dystrophy; BRCA cis rs13046373 0.535 rs1961167 chr21:32030310 T/C cg06468780 chr21:31798236 KRTAP13-3 0.35 8.45 0.32 1.96e-16 HDL cholesterol; BRCA cis rs6987853 0.712 rs2974343 chr8:42400679 G/A cg09913449 chr8:42400586 C8orf40 0.41 9.08 0.34 1.35e-18 Mean corpuscular hemoglobin concentration; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 2.01e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg11814155 chr7:99998594 ZCWPW1 0.49 8.91 0.33 5.41e-18 Platelet count; BRCA cis rs11958404 0.932 rs72816552 chr5:157422376 G/A cg05962755 chr5:157440814 NA 0.52 9.89 0.36 1.52e-21 IgG glycosylation; BRCA cis rs870825 0.616 rs7694899 chr4:185625390 C/T cg04058563 chr4:185651563 MLF1IP 0.74 16.53 0.55 2.4e-51 Blood protein levels; BRCA cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg18850127 chr7:39170497 POU6F2 0.53 11.92 0.43 1.04e-29 IgG glycosylation; BRCA cis rs858239 1.000 rs858239 chr7:23286315 G/A cg23682824 chr7:23144976 KLHL7 0.36 8.95 0.33 3.75e-18 Cerebrospinal fluid biomarker levels; BRCA trans rs2204008 0.743 rs2127952 chr12:37995364 G/T cg06521331 chr12:34319734 NA -0.54 -10.37 -0.38 2.16e-23 Bladder cancer; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg12419862 chr22:24373484 LOC391322 -0.64 -14.69 -0.5 2.79e-42 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2880765 0.743 rs6497191 chr15:86011501 T/C cg10818794 chr15:86012489 AKAP13 -0.31 -8.51 -0.32 1.2e-16 Coronary artery disease; BRCA cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg07952391 chr2:88470173 THNSL2 0.6 9.29 0.34 2.39e-19 Plasma clusterin levels; BRCA trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21659725 chr3:3221576 CRBN 0.49 11.34 0.41 2.88e-27 Resting heart rate; BRCA cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -9.03 -0.34 1.99e-18 Alzheimer's disease (late onset); BRCA cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg08603382 chr10:743973 NA -0.46 -8.67 -0.32 3.64e-17 Psychosis in Alzheimer's disease; BRCA cis rs875971 0.862 rs778720 chr7:65846275 A/C cg18876405 chr7:65276391 NA -0.51 -11.36 -0.41 2.28e-27 Aortic root size; BRCA cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.79 -0.33 1.35e-17 Reticulocyte count; BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg04944784 chr2:26401820 FAM59B -0.69 -11.4 -0.41 1.56e-27 Gut microbiome composition (summer); BRCA cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg06494592 chr3:125709126 NA -0.53 -8.5 -0.32 1.29e-16 Blood pressure (smoking interaction); BRCA cis rs701145 0.585 rs1629659 chr3:153798731 C/T cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs1401999 1.000 rs13317532 chr3:183641669 G/C cg01324343 chr3:183735012 ABCC5 0.84 21.26 0.64 2.76e-76 Anterior chamber depth; BRCA cis rs6500602 0.893 rs4786490 chr16:4491190 C/T cg08645402 chr16:4508243 NA -0.37 -8.81 -0.33 1.22e-17 Schizophrenia; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg13397359 chr6:42928475 GNMT 0.76 19.42 0.61 2.14e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2882667 0.690 rs288026 chr5:138222594 A/G cg04439458 chr5:138467593 SIL1 -0.33 -8.21 -0.31 1.19e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg02574844 chr11:5959923 NA -0.41 -8.5 -0.32 1.38e-16 DNA methylation (variation); BRCA trans rs11098499 0.909 rs1546502 chr4:120235898 A/G cg25214090 chr10:38739885 LOC399744 0.52 11.63 0.42 1.64e-28 Corneal astigmatism; BRCA cis rs6543140 0.964 rs10169192 chr2:103072211 A/G cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs1003719 0.646 rs7276711 chr21:38578189 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs7246657 0.943 rs10405064 chr19:37861861 C/T cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg11584989 chr19:19387371 SF4 0.63 13.4 0.47 2.84e-36 Bipolar disorder; BRCA cis rs1577917 0.652 rs75593931 chr6:86719539 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -12.89 -0.45 6.01e-34 Response to antipsychotic treatment; BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.89 0.33 6.22e-18 Tonsillectomy; BRCA cis rs9560113 1.000 rs61967684 chr13:112178026 G/C cg10483660 chr13:112241077 NA 0.32 7.86 0.3 1.65e-14 Menarche (age at onset); BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.04 -0.34 1.81e-18 Total body bone mineral density; BRCA cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg01884057 chr2:25150051 NA 0.33 8.68 0.32 3.24e-17 Body mass index in non-asthmatics; BRCA trans rs61931739 0.517 rs12816423 chr12:34067736 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.37 0.35 1.19e-19 Morning vs. evening chronotype; BRCA cis rs875971 0.545 rs1065265 chr7:65841203 C/T cg11764359 chr7:65958608 NA 0.63 10.74 0.39 7.39e-25 Aortic root size; BRCA cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg12927641 chr6:109611667 NA -0.41 -10.59 -0.39 3.05e-24 Reticulocyte fraction of red cells; BRCA cis rs17685 0.587 rs1623759 chr7:75724679 A/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.22 -0.31 1.14e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg00750074 chr16:89608354 SPG7 0.38 10.33 0.38 3.05e-23 Multiple myeloma (IgH translocation); BRCA cis rs2991971 0.747 rs2492841 chr1:45894891 G/T cg24296786 chr1:45957014 TESK2 -0.54 -12.73 -0.45 2.96e-33 High light scatter reticulocyte count; BRCA cis rs11718455 0.921 rs1404482 chr3:43997282 A/G cg08738300 chr3:44038990 NA 0.44 8.57 0.32 8.06e-17 Coronary artery disease; BRCA cis rs6772849 0.930 rs6768344 chr3:128373556 G/A cg16766828 chr3:128327626 NA -0.39 -8.64 -0.32 4.64e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.28 -0.44 2.95e-31 Tonsillectomy; BRCA cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg20503657 chr10:835505 NA 0.95 17.83 0.58 5.12e-58 Eosinophil percentage of granulocytes; BRCA trans rs66887589 0.616 rs11098497 chr4:120187068 C/T cg25214090 chr10:38739885 LOC399744 0.37 8.61 0.32 5.53e-17 Diastolic blood pressure; BRCA cis rs922182 0.556 rs12443020 chr15:64215823 G/T cg24729988 chr15:64271149 DAPK2 0.46 9.49 0.35 4.5e-20 Blood protein levels; BRCA cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs1707322 0.717 rs12023439 chr1:46104636 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.99 0.43 5.31e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6060987 1 rs6060987 chr20:30427077 T/A cg21427119 chr20:30132790 HM13 -0.43 -9.28 -0.34 2.51e-19 Mean corpuscular volume; BRCA cis rs6831352 0.819 rs1230158 chr4:99990186 T/C cg12011299 chr4:100065546 ADH4 0.37 9.28 0.34 2.56e-19 Alcohol dependence; BRCA cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.32 -0.31 5.28e-16 Cognitive function; BRCA cis rs17401966 0.800 rs12725210 chr1:10416993 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.57 0.47 4.97e-37 Hepatocellular carcinoma; BRCA cis rs7103648 0.643 rs12365079 chr11:47696596 A/T cg20307385 chr11:47447363 PSMC3 0.74 17.0 0.56 9.98e-54 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1371867 0.846 rs1788205 chr8:101306546 G/C cg06002616 chr8:101225028 SPAG1 -0.34 -8.34 -0.31 4.47e-16 Atrioventricular conduction; BRCA cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg13319975 chr6:146136371 FBXO30 0.42 9.28 0.34 2.62e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs738322 0.804 rs2076116 chr22:38517405 A/G cg25457927 chr22:38595422 NA -0.29 -10.45 -0.38 1.04e-23 Cutaneous nevi; BRCA trans rs7615952 0.576 rs2276729 chr3:125826214 G/A cg07211511 chr3:129823064 LOC729375 -0.63 -11.59 -0.42 2.56e-28 Blood pressure (smoking interaction); BRCA cis rs7666738 0.791 rs6853608 chr4:99047916 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2882667 0.690 rs7722965 chr5:138100455 T/C cg04439458 chr5:138467593 SIL1 0.34 8.41 0.32 2.59e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg04025307 chr7:1156635 C7orf50 0.54 13.6 0.47 3.58e-37 Longevity;Endometriosis; BRCA cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg03264133 chr6:25882463 NA 0.7 16.09 0.54 3.68e-49 Blood metabolite levels; BRCA cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg19784903 chr17:45786737 TBKBP1 0.34 8.06 0.3 3.76e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg23583168 chr7:148888333 NA -0.79 -18.48 -0.59 2.1e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10751667 0.600 rs7950955 chr11:1011490 G/A ch.11.42038R chr11:967971 AP2A2 0.47 14.22 0.49 4.33e-40 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs991168 chr4:98928293 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg24812749 chr6:127587940 RNF146 0.84 19.32 0.61 7.62e-66 Breast cancer; BRCA cis rs16867321 0.588 rs1919156 chr2:181456978 C/T cg23363182 chr2:181467187 NA -0.49 -10.85 -0.39 2.72e-25 Obesity; BRCA cis rs10883723 0.810 rs3818470 chr10:104263675 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.91 0.62 5.12e-69 Allergic disease (asthma, hay fever or eczema); BRCA cis rs11605924 0.692 rs877412 chr11:45897651 A/C ch.11.939596F chr11:45881766 CRY2 0.57 14.12 0.49 1.3e-39 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg01181863 chr3:195395398 SDHAP2 0.49 8.63 0.32 5.03e-17 Pancreatic cancer; BRCA cis rs11718455 0.960 rs1852037 chr3:44003720 G/T cg08738300 chr3:44038990 NA -0.45 -8.81 -0.33 1.18e-17 Coronary artery disease; BRCA cis rs9287719 0.967 rs7592691 chr2:10737426 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg06618935 chr21:46677482 NA -0.37 -8.1 -0.31 2.87e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1691799 0.899 rs1168307 chr12:66739539 A/G cg16791601 chr12:66731901 HELB -0.7 -19.78 -0.62 2.81e-68 White blood cell count (basophil); BRCA cis rs6450176 0.597 rs1541682 chr5:53304401 C/T cg22592108 chr5:53304441 ARL15 0.34 8.1 0.31 2.81e-15 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7098414 0.511 rs10788603 chr10:82148137 G/T cg00277334 chr10:82204260 NA -0.49 -10.57 -0.39 3.61e-24 Post bronchodilator FEV1; BRCA cis rs2832077 0.883 rs35672956 chr21:30189042 T/C cg08807101 chr21:30365312 RNF160 -0.47 -7.97 -0.3 7.37e-15 Cognitive test performance; BRCA cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg27446573 chr6:127587934 RNF146 0.89 20.5 0.63 3.86e-72 Breast cancer; BRCA cis rs9457247 0.663 rs2237277 chr6:167442107 G/A cg07741184 chr6:167504864 NA 0.27 8.1 0.31 2.78e-15 Crohn's disease; BRCA cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg13010199 chr12:38710504 ALG10B 0.43 9.19 0.34 5.3e-19 Morning vs. evening chronotype; BRCA cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.63 0.32 4.71e-17 Motion sickness; BRCA cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 6.53e-87 Chronic sinus infection; BRCA cis rs477692 0.517 rs871026 chr10:131293145 A/G cg05714579 chr10:131428358 MGMT -0.48 -10.62 -0.39 2.21e-24 Response to temozolomide; BRCA cis rs9768139 0.733 rs71545585 chr7:158118672 G/A cg24154853 chr7:158122151 PTPRN2 0.38 8.26 0.31 8.35e-16 Calcium levels; BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 25.61 0.71 4.28e-100 Platelet count; BRCA cis rs61990749 0.597 rs9323650 chr14:78150336 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.63 10.12 0.37 1.97e-22 Fibroblast growth factor basic levels; BRCA cis rs9788682 0.747 rs2915695 chr15:78739471 T/C cg24631222 chr15:78858424 CHRNA5 -0.5 -9.95 -0.37 8.52e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs9400271 0.632 rs9400262 chr6:109591433 T/C cg21918786 chr6:109611834 NA -0.32 -8.1 -0.31 2.78e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg22508957 chr16:3507546 NAT15 0.47 11.67 0.42 1.18e-28 Tuberculosis; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26314531 chr2:26401878 FAM59B -0.88 -15.45 -0.52 5.59e-46 Gut microbiome composition (summer); BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00908189 chr16:619842 PIGQ 0.68 17.0 0.56 9.38e-54 Height; BRCA cis rs3806843 1.000 rs3733710 chr5:140167463 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.8 -0.36 3.27e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs367615 0.918 rs4576198 chr5:108867350 T/G cg17395555 chr5:108820864 NA 0.38 9.67 0.36 1e-20 Colorectal cancer (SNP x SNP interaction); BRCA cis rs7301826 0.627 rs10773823 chr12:131294501 C/T cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 3e-37 Plasma plasminogen activator levels; BRCA cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.45 0.38 1.08e-23 Aortic root size; BRCA trans rs1493916 1.000 rs1493916 chr18:31392577 T/G cg27147174 chr7:100797783 AP1S1 -0.54 -10.89 -0.4 1.83e-25 Life satisfaction; BRCA cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.33e-67 Aortic root size; BRCA cis rs2835872 0.733 rs1709822 chr21:39035485 A/G cg06728970 chr21:39037746 KCNJ6 0.45 12.83 0.45 1.12e-33 Electroencephalographic traits in alcoholism; BRCA cis rs17401966 1.000 rs12755094 chr1:10305711 T/C cg15208524 chr1:10270712 KIF1B 0.36 8.19 0.31 1.42e-15 Hepatocellular carcinoma; BRCA cis rs7582180 0.676 rs1437969 chr2:100983482 A/C cg14675211 chr2:100938903 LONRF2 0.41 9.29 0.35 2.31e-19 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11644478 chr21:40555479 PSMG1 0.84 19.21 0.61 2.91e-65 Cognitive function; BRCA cis rs12210905 0.688 rs12215289 chr6:27468705 T/C cg08851530 chr6:28072375 NA 0.82 8.04 0.3 4.42e-15 Hip circumference adjusted for BMI; BRCA cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg18876405 chr7:65276391 NA 0.55 13.09 0.46 7.42e-35 Aortic root size; BRCA cis rs7011049 0.673 rs72640835 chr8:53828012 T/C cg26025543 chr8:53854495 NA 0.43 7.85 0.3 1.8e-14 Systolic blood pressure; BRCA cis rs16858210 0.657 rs73177515 chr3:183566825 T/A cg25686905 chr3:183603175 PARL -0.39 -8.35 -0.31 4.4e-16 Menopause (age at onset); BRCA cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.0 0.48 4.7e-39 Motion sickness; BRCA cis rs1994135 0.647 rs66542958 chr12:33695385 T/G cg06521331 chr12:34319734 NA -0.44 -8.06 -0.3 3.7e-15 Resting heart rate; BRCA cis rs2073300 1.000 rs6137976 chr20:23463241 C/T cg12062639 chr20:23401060 NAPB 0.83 9.87 0.36 1.77e-21 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -9.22 -0.34 4.42e-19 Colorectal cancer; BRCA cis rs6582630 0.519 rs11514056 chr12:38284001 G/T cg13010199 chr12:38710504 ALG10B 0.41 8.47 0.32 1.64e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs10193935 0.792 rs13423729 chr2:42492874 C/T cg27598129 chr2:42591480 NA -0.58 -9.68 -0.36 9.27e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.89e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg04034577 chr2:241836375 C2orf54 -0.57 -14.0 -0.48 4.96e-39 Urinary metabolites; BRCA cis rs4363385 0.818 rs3795381 chr1:153004848 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.21 -0.34 4.44e-19 Inflammatory skin disease; BRCA trans rs61931739 0.534 rs7133262 chr12:34279444 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.24 0.49 3.81e-40 Morning vs. evening chronotype; BRCA cis rs3862030 0.694 rs41306870 chr10:104229785 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.12e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg12373951 chr3:133503437 NA 0.34 8.03 0.3 4.6e-15 Iron status biomarkers; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg04709771 chr16:646395 RAB40C 0.45 11.23 0.41 8.1e-27 Height; BRCA cis rs3862030 0.836 rs12771867 chr10:104246691 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -13.18 -0.46 3.02e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs7903847 0.642 rs7896100 chr10:99156994 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.83 -0.33 9.93e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs2425143 1.000 rs2425143 chr20:34350666 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.14 -0.37 1.61e-22 Blood protein levels; BRCA cis rs17685 0.672 rs56343450 chr7:75796235 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs311392 0.902 rs438437 chr8:55094187 G/C cg11783602 chr8:55087084 NA -0.32 -9.36 -0.35 1.36e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.81 12.49 0.44 3.53e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6604026 0.740 rs6604031 chr1:93400766 T/G cg17283838 chr1:93427260 FAM69A -0.39 -8.09 -0.3 2.99e-15 Multiple sclerosis; BRCA cis rs7246657 0.943 rs10420430 chr19:37894194 C/G cg23950597 chr19:37808831 NA -0.75 -13.02 -0.46 1.52e-34 Coronary artery calcification; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg18765753 chr7:1198926 ZFAND2A 0.46 10.56 0.39 3.82e-24 Longevity;Endometriosis; BRCA trans rs9325144 0.555 rs7301258 chr12:38706942 C/T cg23762105 chr12:34175262 ALG10 -0.39 -9.58 -0.35 2.07e-20 Morning vs. evening chronotype; BRCA cis rs3771570 0.901 rs35496488 chr2:242434316 G/A cg21155796 chr2:242212141 HDLBP 0.63 9.7 0.36 7.62e-21 Prostate cancer; BRCA cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg20503657 chr10:835505 NA 0.9 13.78 0.48 5.04e-38 Eosinophil percentage of granulocytes; BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg15017067 chr4:17643749 FAM184B 0.31 8.6 0.32 5.99e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17270561 0.636 rs9379779 chr6:25695441 G/T cg17691542 chr6:26056736 HIST1H1C 0.48 9.1 0.34 1.12e-18 Iron status biomarkers; BRCA cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg16576597 chr16:28551801 NUPR1 -0.28 -8.01 -0.3 5.42e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1451375 0.617 rs2329371 chr7:50615440 G/A cg18232548 chr7:50535776 DDC 0.43 9.17 0.34 6.45e-19 Malaria; BRCA cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.48 -9.38 -0.35 1.11e-19 Chronic sinus infection; BRCA cis rs897080 0.552 rs1067397 chr2:44679285 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.31 0.35 1.98e-19 Height; BRCA cis rs11585357 0.895 rs4625336 chr1:17630964 G/T cg08277548 chr1:17600880 PADI3 -0.62 -10.65 -0.39 1.77e-24 Hair shape; BRCA cis rs17095355 0.901 rs12240333 chr10:111743972 T/A cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.64 -0.36 1.26e-20 Biliary atresia; BRCA cis rs9400271 0.632 rs6930844 chr6:109590286 C/A cg21918786 chr6:109611834 NA -0.32 -8.02 -0.3 4.96e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg11843238 chr5:131593191 PDLIM4 -0.37 -7.89 -0.3 1.36e-14 Breast cancer; BRCA cis rs1580019 0.961 rs4255041 chr7:32496383 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.48 0.32 1.51e-16 Cognitive ability; BRCA trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg15704280 chr7:45808275 SEPT13 0.7 14.14 0.49 1.11e-39 Coronary artery disease; BRCA cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs1865721 0.917 rs62089506 chr18:73178913 A/G cg26385618 chr18:73139727 C18orf62 -0.41 -9.23 -0.34 3.87e-19 Intelligence; BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg00106254 chr7:1943704 MAD1L1 -0.42 -11.46 -0.41 8.67e-28 Bipolar disorder and schizophrenia; BRCA cis rs61931739 0.534 rs11052973 chr12:34029708 A/G cg06521331 chr12:34319734 NA -0.62 -11.28 -0.41 5.11e-27 Morning vs. evening chronotype; BRCA cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg22307297 chr20:60903441 LAMA5 -0.34 -9.44 -0.35 6.97e-20 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs7301016 0.846 rs11174569 chr12:63021161 A/C cg01804193 chr12:63026212 NA 0.47 8.41 0.32 2.73e-16 IgG glycosylation; BRCA cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg03146154 chr1:46216737 IPP 0.46 10.21 0.37 8.87e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs3733585 0.699 rs6449202 chr4:9974043 T/C cg26043149 chr18:55253948 FECH -0.36 -7.89 -0.3 1.34e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7086627 0.515 rs10887895 chr10:82210011 A/G cg01528321 chr10:82214614 TSPAN14 0.62 14.12 0.49 1.3e-39 Post bronchodilator FEV1; BRCA trans rs6598955 0.671 rs17257176 chr1:26578233 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.85 19.38 0.61 3.79e-66 Cognitive ability; BRCA cis rs4930103 0.591 rs11042048 chr11:1986240 C/G cg23202291 chr11:1979235 NA 0.4 9.06 0.34 1.61e-18 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg00339695 chr16:24857497 SLC5A11 -0.34 -8.25 -0.31 8.84e-16 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg04025307 chr7:1156635 C7orf50 0.58 14.65 0.5 4.28e-42 Longevity;Endometriosis; BRCA cis rs12200560 0.505 rs211163 chr6:97067654 A/G cg06623918 chr6:96969491 KIAA0776 0.51 12.06 0.43 2.45e-30 Coronary heart disease; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg19346786 chr7:2764209 NA -0.37 -11.15 -0.4 1.64e-26 Height; BRCA cis rs34779708 0.897 rs9665538 chr10:35461038 T/C cg03585969 chr10:35415529 CREM 0.48 10.19 0.37 1.07e-22 Inflammatory bowel disease;Crohn's disease; BRCA trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.89 0.3 1.33e-14 Corneal astigmatism; BRCA cis rs250677 0.522 rs4431331 chr5:148353574 A/C cg18129178 chr5:148520854 ABLIM3 -0.5 -9.64 -0.36 1.24e-20 Breast cancer; BRCA cis rs7827545 0.545 rs6988000 chr8:135559534 C/T cg17885191 chr8:135476712 NA 0.58 9.99 0.37 6.27e-22 Hypertension (SNP x SNP interaction); BRCA cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.12 0.37 1.91e-22 Bladder cancer; BRCA cis rs9296092 0.500 rs35150558 chr6:33519612 T/A cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs4953076 0.573 rs7602070 chr2:44388614 G/A cg04920474 chr2:44395004 PPM1B 0.48 10.07 0.37 3.18e-22 Height; BRCA cis rs7119 1.000 rs7119 chr15:77777632 C/T cg17802220 chr15:77601643 NA -0.33 -8.11 -0.31 2.57e-15 Type 2 diabetes; BRCA cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg11584989 chr19:19387371 SF4 0.63 13.56 0.47 5.66e-37 Bipolar disorder; BRCA cis rs782590 0.935 rs782652 chr2:55862775 C/A cg18811423 chr2:55921094 PNPT1 0.73 23.61 0.68 4.33e-89 Metabolic syndrome; BRCA cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.41 0.32 2.77e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg13319975 chr6:146136371 FBXO30 -0.54 -12.08 -0.43 2.01e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs754466 0.561 rs72806025 chr10:79707026 C/T cg17075019 chr10:79541650 NA -0.54 -8.13 -0.31 2.21e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2404602 0.647 rs11072625 chr15:77084984 A/G cg23625390 chr15:77176239 SCAPER 0.52 12.36 0.44 1.31e-31 Blood metabolite levels; BRCA cis rs9402673 0.558 rs9688342 chr6:135323026 A/T cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 8.89e-33 Reticulocyte count;High light scatter reticulocyte count; BRCA cis rs4363385 0.818 rs10788853 chr1:153002231 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.42 -0.32 2.38e-16 Inflammatory skin disease; BRCA cis rs514406 0.505 rs835609 chr1:53170494 T/C cg24675658 chr1:53192096 ZYG11B -0.61 -14.12 -0.49 1.31e-39 Monocyte count; BRCA cis rs16958440 1.000 rs61316646 chr18:44610670 G/C cg17192377 chr18:44677553 HDHD2 0.67 9.76 0.36 4.65e-21 Sitting height ratio; BRCA cis rs13136331 0.721 rs2627717 chr4:88684745 C/T cg22416721 chr4:88570574 DMP1 -0.52 -12.29 -0.44 2.52e-31 Sitting height ratio; BRCA cis rs868036 0.609 rs2278076 chr15:68099600 C/T cg24579218 chr15:68104479 NA -0.36 -7.83 -0.3 1.97e-14 Restless legs syndrome; BRCA cis rs524281 0.861 rs10896081 chr11:65880354 A/T cg16950941 chr11:66035639 RAB1B -0.39 -8.56 -0.32 8.12e-17 Electroencephalogram traits; BRCA cis rs208520 0.954 rs12190073 chr6:66983740 T/C cg07460842 chr6:66804631 NA 0.88 14.29 0.49 2.04e-40 Exhaled nitric oxide output; BRCA cis rs6748734 0.779 rs6437371 chr2:241797424 G/C cg02820040 chr2:241836501 C2orf54 -0.47 -9.16 -0.34 6.78e-19 Urinary metabolites; BRCA cis rs1949733 0.523 rs16842563 chr4:8545146 C/T cg11789530 chr4:8429930 ACOX3 -0.55 -12.79 -0.45 1.7e-33 Response to antineoplastic agents; BRCA cis rs9868809 0.505 rs11706203 chr3:48746239 T/A cg00383909 chr3:49044727 WDR6 0.58 10.53 0.38 4.88e-24 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg17330251 chr7:94953956 PON1 -0.42 -8.78 -0.33 1.52e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg08564027 chr20:61660810 NA 0.85 22.12 0.66 6.49e-81 Prostate cancer (SNP x SNP interaction); BRCA cis rs11958404 0.860 rs11135023 chr5:157420082 G/T cg05962755 chr5:157440814 NA 0.45 9.44 0.35 6.92e-20 IgG glycosylation; BRCA cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg07537917 chr2:241836409 C2orf54 -0.49 -11.68 -0.42 1.08e-28 Urinary metabolites; BRCA cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg08885076 chr2:99613938 TSGA10 -0.53 -11.74 -0.42 5.88e-29 Chronic sinus infection; BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.21 0.34 4.65e-19 Tonsillectomy; BRCA cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg03676636 chr4:99064102 C4orf37 0.22 8.07 0.3 3.51e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg16339924 chr4:17578868 LAP3 0.67 17.11 0.56 2.65e-54 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg12516959 chr21:47718080 NA -0.34 -8.29 -0.31 6.75e-16 Testicular germ cell tumor; BRCA cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.38 -0.31 3.27e-16 Aortic root size; BRCA trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg15556689 chr8:8085844 FLJ10661 -0.44 -12.45 -0.44 5.45e-32 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs1891275 0.515 rs1361552 chr10:93534624 T/C cg07889827 chr10:93443413 NA -0.41 -11.27 -0.41 5.27e-27 Intelligence (multi-trait analysis); BRCA cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg06022373 chr22:39101656 GTPBP1 0.73 18.11 0.58 1.89e-59 Menopause (age at onset); BRCA trans rs561341 1.000 rs550923 chr17:30327013 G/C cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.28e-27 Hip circumference adjusted for BMI; BRCA cis rs9616064 0.531 rs867212 chr22:47063330 C/T cg05621596 chr22:47072043 GRAMD4 0.65 14.23 0.49 3.92e-40 Urate levels in obese individuals; BRCA cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg24531977 chr5:56204891 C5orf35 -0.88 -18.17 -0.58 8.2e-60 Initial pursuit acceleration; BRCA cis rs13394619 1.000 rs2884374 chr2:11731846 C/T cg07314298 chr2:11723111 GREB1 0.52 11.89 0.43 1.37e-29 Endometriosis; BRCA cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg15352829 chr14:105391018 PLD4 0.38 12.12 0.43 1.41e-30 Rheumatoid arthritis; BRCA cis rs8180040 0.902 rs73081205 chr3:47517670 A/C cg27129171 chr3:47204927 SETD2 -0.68 -16.12 -0.54 2.59e-49 Colorectal cancer; BRCA cis rs870825 0.616 rs3184982 chr4:185615768 T/G cg04058563 chr4:185651563 MLF1IP 0.78 17.17 0.56 1.32e-54 Blood protein levels; BRCA cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg05340658 chr4:99064831 C4orf37 0.58 11.85 0.42 1.93e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg21280719 chr6:42927975 GNMT 0.29 12.71 0.45 3.64e-33 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs3857536 0.813 rs4710581 chr6:66939954 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs7572733 0.534 rs10931794 chr2:198776140 C/T cg00792783 chr2:198669748 PLCL1 -0.48 -10.32 -0.38 3.35e-23 Dermatomyositis; BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg20607798 chr8:58055168 NA 0.6 9.24 0.34 3.61e-19 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.5 0.32 1.35e-16 Bladder cancer; BRCA cis rs96067 0.711 rs272811 chr1:36634414 G/A cg24686825 chr1:36642396 MAP7D1 -0.57 -11.56 -0.42 3.44e-28 Corneal structure; BRCA cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg01579765 chr21:45077557 HSF2BP -0.36 -9.64 -0.36 1.26e-20 Mean corpuscular volume; BRCA cis rs6964587 0.620 rs6967588 chr7:91643402 G/T cg17063962 chr7:91808500 NA 0.55 12.63 0.45 8.24e-33 Breast cancer; BRCA cis rs9814567 1.000 rs9990351 chr3:134239191 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.58 19.52 0.61 6.5e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6963495 0.745 rs56239334 chr7:105165351 G/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg04025307 chr7:1156635 C7orf50 0.47 9.14 0.34 8.42e-19 Bronchopulmonary dysplasia; BRCA cis rs9976767 0.608 rs9784208 chr21:43824986 A/G cg23042151 chr21:43824109 UBASH3A -0.27 -8.48 -0.32 1.57e-16 Type 1 diabetes; BRCA cis rs6684514 1.000 rs10908500 chr1:156280671 A/T cg16558208 chr1:156270281 VHLL 0.35 8.07 0.3 3.53e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg06550200 chr5:1325588 CLPTM1L -0.65 -14.03 -0.49 3.54e-39 Lung cancer; BRCA cis rs2980436 1 rs2980436 chr8:8092025 A/G cg06636001 chr8:8085503 FLJ10661 -0.78 -17.87 -0.58 3.18e-58 Schizophrenia; BRCA cis rs459571 0.959 rs465724 chr9:136910097 C/T cg13789015 chr9:136890014 NCRNA00094 0.55 11.43 0.41 1.14e-27 Platelet distribution width; BRCA cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg25358565 chr5:93447407 FAM172A 1.21 18.85 0.6 2.32e-63 Diabetic retinopathy; BRCA cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.81 -0.36 2.86e-21 IgG glycosylation; BRCA cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg02659138 chr7:134003124 SLC35B4 0.34 10.47 0.38 8.67e-24 Mean platelet volume; BRCA cis rs2011503 0.882 rs8108777 chr19:19359058 C/A cg11584989 chr19:19387371 SF4 0.55 12.35 0.44 1.43e-31 Bipolar disorder; BRCA cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg21395723 chr22:39101663 GTPBP1 0.39 8.28 0.31 7.23e-16 Menopause (age at onset); BRCA cis rs2625529 0.713 rs16956634 chr15:72552243 C/G cg16672083 chr15:72433130 SENP8 0.77 15.77 0.53 1.49e-47 Red blood cell count; BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.72 15.73 0.53 2.39e-47 Lymphocyte counts; BRCA cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg14558114 chr2:88469736 THNSL2 0.63 9.17 0.34 6.56e-19 Plasma clusterin levels; BRCA cis rs7851660 0.527 rs7870795 chr9:100574120 A/G cg13688889 chr9:100608707 NA -0.51 -11.92 -0.43 1.03e-29 Strep throat; BRCA cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg22834771 chr12:69754056 YEATS4 -0.37 -9.05 -0.34 1.68e-18 Blood protein levels; BRCA cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg13902645 chr11:5959945 NA -0.48 -9.8 -0.36 3.33e-21 DNA methylation (variation); BRCA cis rs758324 0.947 rs4493667 chr5:131247218 G/T cg06307176 chr5:131281290 NA -0.52 -10.16 -0.37 1.38e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs17270561 0.636 rs1165157 chr6:25792250 A/G cg17691542 chr6:26056736 HIST1H1C 0.43 9.27 0.34 2.89e-19 Iron status biomarkers; BRCA cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.63 -0.36 1.33e-20 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11890956 chr21:40555474 PSMG1 -0.62 -13.74 -0.48 7.58e-38 Menarche (age at onset); BRCA cis rs7577696 0.597 rs17011801 chr2:32298072 A/T cg02381751 chr2:32503542 YIPF4 -0.42 -7.99 -0.3 6.45e-15 Inflammatory biomarkers; BRCA cis rs6964587 1.000 rs9969198 chr7:91567492 G/T cg17063962 chr7:91808500 NA -0.52 -12.15 -0.43 1e-30 Breast cancer; BRCA cis rs11098499 0.954 rs67265404 chr4:120359270 C/T cg09307838 chr4:120376055 NA 0.71 14.86 0.51 4.18e-43 Corneal astigmatism; BRCA cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.18 0.46 2.94e-35 Intelligence (multi-trait analysis); BRCA cis rs950776 0.714 rs472054 chr15:78887994 A/G cg06917634 chr15:78832804 PSMA4 -0.56 -11.65 -0.42 1.44e-28 Sudden cardiac arrest; BRCA cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg13319975 chr6:146136371 FBXO30 0.62 14.55 0.5 1.28e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs875971 0.658 rs432667 chr7:65514633 A/G cg18876405 chr7:65276391 NA 0.58 13.94 0.48 9.77e-39 Aortic root size; BRCA cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24308560 chr3:49941425 MST1R -0.39 -8.23 -0.31 1.08e-15 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.78 0.33 1.45e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs67981189 0.593 rs2526871 chr14:71385113 G/A cg15816911 chr14:71606274 NA -0.37 -8.45 -0.32 2e-16 Schizophrenia; BRCA cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg04025307 chr7:1156635 C7orf50 -0.43 -9.64 -0.36 1.22e-20 Longevity;Endometriosis; BRCA cis rs72627509 0.904 rs56281640 chr4:57765816 G/A cg26694713 chr4:57773883 REST 0.52 10.24 0.38 6.91e-23 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs74417235 0.684 rs13185173 chr5:154055081 A/G cg08754654 chr5:154026448 NA 0.43 10.07 0.37 3.12e-22 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs6545883 0.895 rs2256617 chr2:61679924 A/G cg15711740 chr2:61764176 XPO1 -0.53 -13.28 -0.47 1.02e-35 Tuberculosis; BRCA cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg09184832 chr6:79620586 NA -0.49 -10.63 -0.39 2.06e-24 Intelligence (multi-trait analysis); BRCA cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg02175503 chr12:58329896 NA 0.4 7.98 0.3 6.88e-15 Intelligence (multi-trait analysis); BRCA cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 9.79 0.36 3.65e-21 Bipolar disorder; BRCA cis rs3772130 0.962 rs11707518 chr3:121496568 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.56 9.87 0.36 1.78e-21 Cognitive performance; BRCA cis rs490234 0.841 rs1755936 chr9:128388991 C/G cg14078157 chr9:128172775 NA -0.35 -8.29 -0.31 6.88e-16 Mean arterial pressure; BRCA cis rs9837602 1.000 rs1688772 chr3:99503366 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -10.77 -0.39 5.51e-25 Breast cancer; BRCA cis rs17401966 0.540 rs6541094 chr1:10467074 G/A cg03954927 chr1:10346856 KIF1B 0.34 10.08 0.37 2.78e-22 Hepatocellular carcinoma; BRCA cis rs66569888 0.581 rs17271098 chr2:106692818 A/G cg16099169 chr2:106886729 NA 0.54 9.83 0.36 2.59e-21 Facial morphology (factor 23); BRCA trans rs10838798 0.523 rs4752917 chr11:48241639 A/G cg00717180 chr2:96193071 NA -0.36 -9.93 -0.37 1.06e-21 Height; BRCA cis rs3760982 0.585 rs4803659 chr19:44290235 C/T cg12072164 chr19:44306565 LYPD5 0.36 8.62 0.32 5.08e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg12432903 chr7:1882776 MAD1L1 0.46 8.15 0.31 1.96e-15 Bipolar disorder; BRCA cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg08000102 chr2:233561755 GIGYF2 -0.61 -13.6 -0.47 3.61e-37 Coronary artery disease; BRCA cis rs3733585 0.753 rs1122141 chr4:9947278 T/C cg00071950 chr4:10020882 SLC2A9 -0.51 -12.33 -0.44 1.73e-31 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2177596 0.549 rs4592846 chr2:227948866 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.12 -0.34 9.83e-19 Body mass index; BRCA cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg10932868 chr11:921992 NA 0.49 12.66 0.45 6.42e-33 Alzheimer's disease (late onset); BRCA cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg08992911 chr2:238395768 MLPH 0.4 7.91 0.3 1.14e-14 Prostate cancer; BRCA cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg22455342 chr2:225449267 CUL3 0.66 17.05 0.56 5.19e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs1994135 0.608 rs1482994 chr12:33713631 T/C cg06521331 chr12:34319734 NA -0.54 -9.38 -0.35 1.11e-19 Resting heart rate; BRCA trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.1 0.31 2.79e-15 Corneal astigmatism; BRCA trans rs6600671 1.000 rs4844380 chr1:121193620 A/T cg17023122 chr1:144479586 NA 0.34 7.94 0.3 9.34e-15 Hip geometry; BRCA cis rs2625529 0.652 rs2929532 chr15:72345110 C/T cg16672083 chr15:72433130 SENP8 0.67 16.17 0.54 1.53e-49 Red blood cell count; BRCA cis rs2421770 0.504 rs4756213 chr11:35363566 T/C cg13971030 chr11:35366721 SLC1A2 -0.44 -9.73 -0.36 5.79e-21 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs7666738 0.519 rs28539191 chr4:98821552 C/T cg05340658 chr4:99064831 C4orf37 0.55 10.59 0.39 2.88e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7923452 0.507 rs612802 chr10:30756441 G/A cg18806716 chr10:30721971 MAP3K8 -0.42 -10.05 -0.37 3.56e-22 Itch intensity from mosquito bite; BRCA cis rs2594714 0.538 rs895819 chr19:13947292 A/G cg17299615 chr19:13944571 NA 0.39 8.28 0.31 6.95e-16 Breast cancer; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg07262247 chr5:131593730 PDLIM4 0.37 8.76 0.33 1.71e-17 Acylcarnitine levels; BRCA cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 8.73e-16 Height; BRCA cis rs701145 0.585 rs6789213 chr3:153792795 T/C cg12800244 chr3:153838788 SGEF 0.62 7.82 0.3 2.21e-14 Coronary artery disease; BRCA cis rs910316 0.967 rs175498 chr14:75536369 G/A cg23033748 chr14:75592666 NEK9 -0.42 -10.2 -0.37 1.02e-22 Height; BRCA cis rs2985684 0.740 rs2883438 chr14:50044392 T/C cg04989706 chr14:50066350 PPIL5 -0.48 -9.26 -0.34 3e-19 Carotid intima media thickness; BRCA cis rs1401999 0.565 rs4912515 chr3:183653718 A/G cg01324343 chr3:183735012 ABCC5 0.48 11.04 0.4 4.52e-26 Anterior chamber depth; BRCA cis rs6809651 0.524 rs6444106 chr3:185811495 C/T cg00760338 chr3:185826511 ETV5 -0.47 -9.39 -0.35 1.07e-19 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs1878931 0.858 rs3760083 chr16:3450052 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.81 -18.58 -0.59 6.55e-62 Body mass index (adult); BRCA trans rs8073060 0.544 rs9912939 chr17:34005264 T/G cg19694781 chr19:47549865 TMEM160 -1.05 -21.46 -0.65 2.49e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9469578 1.000 rs16869458 chr6:33714639 C/T cg18708504 chr6:33715942 IP6K3 0.7 10.19 0.37 1.09e-22 Phosphorus levels; BRCA cis rs9341808 0.690 rs3805926 chr6:80879280 C/G cg08355045 chr6:80787529 NA 0.39 9.8 0.36 3.31e-21 Sitting height ratio; BRCA cis rs6546550 0.901 rs6729760 chr2:70161032 C/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.57 -0.42 3.16e-28 Prevalent atrial fibrillation; BRCA cis rs7319311 1.000 rs7320755 chr13:111031092 C/G cg05272587 chr13:111038400 COL4A2 -0.44 -10.48 -0.38 8.32e-24 Bipolar disorder and schizophrenia; BRCA cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg17330251 chr7:94953956 PON1 0.42 9.04 0.34 1.82e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg19077165 chr18:44547161 KATNAL2 -0.59 -12.98 -0.46 2.37e-34 Personality dimensions; BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.17 0.31 1.61e-15 Tonsillectomy; BRCA cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg21427119 chr20:30132790 HM13 -0.44 -9.3 -0.35 2.16e-19 Mean corpuscular hemoglobin; BRCA cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg21644426 chr2:191273491 MFSD6 -0.42 -10.63 -0.39 2.14e-24 Pulse pressure; BRCA cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 8.44 0.32 2.11e-16 Educational attainment; BRCA cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.18 -0.37 1.14e-22 Initial pursuit acceleration; BRCA cis rs11252926 0.563 rs11252290 chr10:461989 C/T cg18196295 chr10:418757 DIP2C 0.46 10.99 0.4 7.25e-26 Psychosis in Alzheimer's disease; BRCA cis rs7617480 0.648 rs6796790 chr3:48780317 G/A cg07636037 chr3:49044803 WDR6 0.89 20.86 0.64 4.14e-74 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs9486715 0.867 rs3849199 chr6:97049191 T/C cg06623918 chr6:96969491 KIAA0776 -0.92 -26.51 -0.72 5.11e-105 Headache; BRCA cis rs9649465 1.000 rs2109723 chr7:123325339 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs2115630 1.000 rs2115630 chr15:85364516 C/T cg11189052 chr15:85197271 WDR73 -0.33 -7.81 -0.3 2.38e-14 P wave terminal force; BRCA cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg26597838 chr10:835615 NA 1.3 21.81 0.65 2.87e-79 Eosinophil percentage of granulocytes; BRCA trans rs2204008 0.774 rs3910796 chr12:38230660 G/T cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg22105103 chr4:187893119 NA 0.36 11.7 0.42 8.8e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs514406 0.825 rs487453 chr1:53271225 T/C cg16325326 chr1:53192061 ZYG11B -0.65 -16.14 -0.54 2.19e-49 Monocyte count; BRCA cis rs724568 0.546 rs1367458 chr2:67946328 C/T cg14046302 chr2:67939758 NA -0.38 -10.55 -0.39 4.12e-24 Major depressive disorder (broad); BRCA cis rs367943 0.966 rs348945 chr5:112822889 C/T cg12552261 chr5:112820674 MCC -0.55 -12.07 -0.43 2.28e-30 Type 2 diabetes; BRCA cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.56e-18 Motion sickness; BRCA cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.89e-29 Chronic sinus infection; BRCA cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.29 0.38 4.41e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg23887609 chr12:130822674 PIWIL1 0.41 9.03 0.34 2.05e-18 Menopause (age at onset); BRCA cis rs151349 0.714 rs6026647 chr20:57606791 C/T cg23907860 chr20:57583709 CTSZ -0.36 -8.46 -0.32 1.76e-16 Platelet distribution width; BRCA cis rs911186 0.786 rs3800307 chr6:27185792 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.31 -8.63 -0.32 4.95e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.2 -0.34 5.17e-19 Bipolar disorder; BRCA cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg20307385 chr11:47447363 PSMC3 -0.42 -8.36 -0.31 3.86e-16 Subjective well-being; BRCA cis rs9790314 0.846 rs7627528 chr3:160990878 A/G cg03342759 chr3:160939853 NMD3 -0.71 -17.75 -0.57 1.29e-57 Morning vs. evening chronotype; BRCA cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg05340658 chr4:99064831 C4orf37 0.58 11.85 0.42 1.93e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg16482183 chr6:26056742 HIST1H1C 0.53 11.36 0.41 2.21e-27 Height; BRCA cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg22903657 chr4:1355424 KIAA1530 -0.37 -7.94 -0.3 9.11e-15 Obesity-related traits; BRCA cis rs10208940 0.777 rs4513330 chr2:68850921 C/T cg12452813 chr2:68675892 NA -0.48 -8.64 -0.32 4.47e-17 Urate levels in lean individuals; BRCA cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg06046430 chr4:77819534 ANKRD56 0.58 12.69 0.45 4.58e-33 Emphysema distribution in smoking; BRCA cis rs7246657 0.722 rs2909100 chr19:38212680 C/T cg14683738 chr19:37701593 ZNF585B -0.47 -8.02 -0.3 5.04e-15 Coronary artery calcification; BRCA cis rs6426558 0.537 rs4653813 chr1:227461510 G/C cg10327440 chr1:227177885 CDC42BPA 0.48 9.57 0.35 2.21e-20 Neutrophil percentage of white cells; BRCA cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg14926445 chr8:58193284 C8orf71 -0.47 -9.0 -0.34 2.48e-18 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg06784218 chr1:46089804 CCDC17 -0.49 -11.41 -0.41 1.48e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg24060327 chr5:131705240 SLC22A5 -0.49 -10.38 -0.38 1.93e-23 Blood metabolite levels; BRCA cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.23 8.04 0.3 4.4e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs17401966 0.931 rs4240911 chr1:10307453 A/G cg03954927 chr1:10346856 KIF1B 0.44 14.7 0.5 2.45e-42 Hepatocellular carcinoma; BRCA cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg23173402 chr1:227635558 NA 0.48 8.89 0.33 6.09e-18 Major depressive disorder; BRCA cis rs6496044 0.568 rs6496049 chr15:86069205 C/G cg10818794 chr15:86012489 AKAP13 -0.29 -8.0 -0.3 5.67e-15 Interstitial lung disease; BRCA cis rs7264396 0.515 rs2425134 chr20:34339439 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.92 -0.43 9.92e-30 Total cholesterol levels; BRCA cis rs8016982 0.674 rs6574631 chr14:81675772 C/T cg01989461 chr14:81687754 GTF2A1 0.72 16.81 0.55 9.26e-53 Schizophrenia; BRCA cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs385076 0.503 rs212702 chr2:32444250 A/G cg02381751 chr2:32503542 YIPF4 0.45 7.92 0.3 1.09e-14 Interleukin-18 levels; BRCA cis rs7254827 0.737 rs35557167 chr19:17171887 G/C cg19418318 chr19:17219073 MYO9B -0.48 -10.07 -0.37 3.1e-22 Mean platelet volume; BRCA cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg17848003 chr1:3704513 LRRC47 0.25 8.56 0.32 8.47e-17 Red cell distribution width; BRCA cis rs17270561 0.666 rs1937129 chr6:25789132 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 9.31 0.35 2.09e-19 Iron status biomarkers; BRCA cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg18479299 chr3:125709523 NA -0.52 -8.77 -0.33 1.68e-17 Blood pressure (smoking interaction); BRCA cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg20891558 chr2:74357851 NA 0.51 12.19 0.43 7.01e-31 Gestational age at birth (maternal effect); BRCA cis rs1003719 0.788 rs9977602 chr21:38450650 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.24e-40 Eye color traits; BRCA trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21659725 chr3:3221576 CRBN -0.47 -12.06 -0.43 2.45e-30 Intelligence (multi-trait analysis); BRCA cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg10978503 chr1:24200527 CNR2 0.52 13.93 0.48 9.94e-39 Immature fraction of reticulocytes; BRCA cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg08999081 chr20:33150536 PIGU -0.44 -12.35 -0.44 1.48e-31 Glomerular filtration rate (creatinine); BRCA cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg06550200 chr5:1325588 CLPTM1L 0.56 11.54 0.42 4.1e-28 Lung cancer; BRCA cis rs9467773 0.620 rs2498351 chr6:26659642 C/T cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.02e-42 Intelligence (multi-trait analysis); BRCA cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg27121462 chr16:89883253 FANCA -0.53 -11.46 -0.41 8.68e-28 Vitiligo; BRCA cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.22e-27 High light scatter reticulocyte count; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.57e-17 Total body bone mineral density; BRCA cis rs332507 0.830 rs11718359 chr3:124395987 G/A cg05980111 chr3:124395277 KALRN 0.36 8.4 0.32 2.92e-16 Plateletcrit; BRCA cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg01579765 chr21:45077557 HSF2BP -0.4 -10.5 -0.38 6.78e-24 Mean corpuscular volume; BRCA cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg03146154 chr1:46216737 IPP -0.44 -9.6 -0.35 1.84e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9399135 0.967 rs4896125 chr6:135342569 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.41 0.44 8.13e-32 Red blood cell count; BRCA cis rs4481887 0.927 rs7524700 chr1:248472816 A/G cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg20607798 chr8:58055168 NA -0.62 -9.66 -0.36 1.06e-20 Developmental language disorder (linguistic errors); BRCA cis rs795484 0.633 rs904661 chr12:118581860 C/T cg16572268 chr12:118583242 PEBP1 0.3 7.93 0.3 9.64e-15 Morphine dose requirement in tonsillectomy and adenoidectomy surgery; BRCA cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.53 -9.23 -0.34 4.03e-19 Schizophrenia; BRCA cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.1 0.46 6.97e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg08847533 chr14:75593920 NEK9 0.91 23.19 0.68 8.49e-87 Height; BRCA cis rs9467773 1.000 rs9393728 chr6:26509330 C/G cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.23e-20 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.706 rs4129858 chr1:183004334 A/G ch.1.3577855R chr1:183094577 LAMC1 0.49 11.22 0.41 8.44e-27 Fuchs's corneal dystrophy; BRCA cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.85 0.39 2.86e-25 Rheumatoid arthritis; BRCA cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg11941060 chr3:133502564 NA -0.58 -13.65 -0.48 2.05e-37 Iron status biomarkers; BRCA trans rs2262909 0.962 rs73019889 chr19:22277826 C/G cg17074339 chr11:11642133 GALNTL4 0.44 8.48 0.32 1.5e-16 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg16386425 chr10:429943 DIP2C -0.39 -8.09 -0.3 3e-15 Psychosis in Alzheimer's disease; BRCA cis rs2629540 0.889 rs7090422 chr10:126439361 T/A cg08799069 chr10:126477246 METTL10 -0.54 -11.73 -0.42 6.57e-29 Cocaine dependence; BRCA cis rs2243480 1.000 rs7456042 chr7:65299778 T/C cg18252515 chr7:66147081 NA -0.81 -11.34 -0.41 2.84e-27 Diabetic kidney disease; BRCA cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.41 -0.54 9.05e-51 Alzheimer's disease (late onset); BRCA cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg06115741 chr20:33292138 TP53INP2 0.45 10.03 0.37 4.49e-22 Coronary artery disease; BRCA cis rs7191700 0.511 rs12923756 chr16:11359675 C/T cg00044050 chr16:11439710 C16orf75 -0.4 -9.24 -0.34 3.58e-19 Multiple sclerosis; BRCA cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg25554036 chr4:6271136 WFS1 0.42 9.98 0.37 6.91e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs11098499 0.954 rs28572238 chr4:120316686 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.98 0.3 6.79e-15 Corneal astigmatism; BRCA cis rs6121246 0.909 rs1075698 chr20:30387992 G/C cg13852791 chr20:30311386 BCL2L1 0.84 16.41 0.54 9.67e-51 Mean corpuscular hemoglobin; BRCA cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg13628971 chr7:2884303 GNA12 0.38 8.54 0.32 1e-16 Height; BRCA cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg09184832 chr6:79620586 NA -0.51 -11.33 -0.41 3.1e-27 Intelligence (multi-trait analysis); BRCA cis rs7829975 0.606 rs7819827 chr8:8797055 G/C cg08975724 chr8:8085496 FLJ10661 -0.41 -8.71 -0.33 2.64e-17 Mood instability; BRCA cis rs2832077 0.527 rs2142375 chr21:30223742 G/A cg24692254 chr21:30365293 RNF160 -0.52 -11.83 -0.42 2.44e-29 Cognitive test performance; BRCA cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.38 0.38 2.02e-23 Motion sickness; BRCA cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.51 -0.32 1.21e-16 Colorectal cancer; BRCA cis rs9487051 0.768 rs398944 chr6:109523444 T/G cg21918786 chr6:109611834 NA -0.35 -9.24 -0.34 3.73e-19 Reticulocyte fraction of red cells; BRCA cis rs10751667 0.961 rs10902263 chr11:992691 A/C cg10932868 chr11:921992 NA -0.38 -9.05 -0.34 1.72e-18 Alzheimer's disease (late onset); BRCA trans rs2235573 0.527 rs139865 chr22:38353932 C/G cg19894588 chr14:64061835 NA 0.37 8.93 0.33 4.48e-18 Glioblastoma;Glioma; BRCA cis rs1506636 1.000 rs600774 chr7:123397831 C/T cg03229431 chr7:123269106 ASB15 0.61 13.56 0.47 5.64e-37 Plateletcrit;Platelet count; BRCA cis rs12188164 0.580 rs2672755 chr5:457249 G/T cg26850624 chr5:429559 AHRR 0.33 7.9 0.3 1.22e-14 Cystic fibrosis severity; BRCA cis rs9768139 0.611 rs12698211 chr7:158119623 G/A cg24154853 chr7:158122151 PTPRN2 0.35 8.16 0.31 1.73e-15 Calcium levels; BRCA cis rs4561483 0.801 rs4511557 chr16:11949458 T/C cg08843971 chr16:11963173 GSPT1 0.51 11.43 0.41 1.16e-27 Testicular germ cell tumor; BRCA cis rs9527 0.590 rs7067663 chr10:104883650 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.8 0.39 4.25e-25 Arsenic metabolism; BRCA trans rs747782 0.582 rs7949865 chr11:48346202 A/C cg15704280 chr7:45808275 SEPT13 -0.52 -8.0 -0.3 5.75e-15 Intraocular pressure; BRCA cis rs17401966 1.000 rs12402052 chr1:10318652 C/G cg15208524 chr1:10270712 KIF1B 0.39 8.43 0.32 2.24e-16 Hepatocellular carcinoma; BRCA cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg11266682 chr4:10021025 SLC2A9 0.39 10.07 0.37 3.05e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.68 14.53 0.5 1.51e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg02734326 chr4:10020555 SLC2A9 0.36 7.92 0.3 1.04e-14 Bone mineral density; BRCA cis rs10504073 0.647 rs4493918 chr8:50015937 C/G cg00325661 chr8:49890786 NA 0.44 12.52 0.44 2.54e-32 Blood metabolite ratios; BRCA cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -11.01 -0.4 5.99e-26 Bone mineral density; BRCA cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.14 -0.34 8.3e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7178424 0.742 rs12915825 chr15:62175636 A/G cg00456672 chr15:62358751 C2CD4A -0.37 -8.95 -0.33 3.74e-18 Height; BRCA cis rs7737355 0.853 rs6873582 chr5:130892741 A/G cg06307176 chr5:131281290 NA 0.53 10.53 0.38 5.24e-24 Life satisfaction; BRCA cis rs2832191 0.967 rs1999321 chr21:30530233 A/C cg24692254 chr21:30365293 RNF160 0.61 15.44 0.52 6.14e-46 Dental caries; BRCA cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg16586182 chr3:47516702 SCAP -0.56 -12.91 -0.45 5.02e-34 Colorectal cancer; BRCA cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg17143192 chr8:8559678 CLDN23 0.53 10.23 0.38 7.52e-23 Obesity-related traits; BRCA cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg24642439 chr20:33292090 TP53INP2 0.42 8.83 0.33 9.85e-18 Height; BRCA cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.77 0.6 6.25e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6430585 0.583 rs3769008 chr2:136586183 C/T cg07169764 chr2:136633963 MCM6 1.25 30.25 0.77 1.89e-125 Corneal structure; BRCA cis rs1499972 0.941 rs62264782 chr3:117655445 C/A cg07612923 chr3:117604196 NA 0.6 8.11 0.31 2.61e-15 Schizophrenia; BRCA cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg27129171 chr3:47204927 SETD2 0.57 11.88 0.43 1.48e-29 Birth weight; BRCA trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg06636001 chr8:8085503 FLJ10661 0.48 9.96 0.37 8.28e-22 Retinal vascular caliber; BRCA cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.76 0.36 4.41e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.837 rs4432085 chr12:38181146 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.14 0.56 1.9e-54 Bladder cancer; BRCA cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg00800038 chr16:89945340 TCF25 -0.57 -9.34 -0.35 1.59e-19 Skin colour saturation; BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg01262667 chr19:19385393 TM6SF2 0.41 10.73 0.39 8.34e-25 Tonsillectomy; BRCA cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg23711669 chr6:146136114 FBXO30 -0.79 -19.25 -0.61 1.82e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs2979489 0.891 rs7822839 chr8:30354453 A/G cg26383811 chr8:30366931 RBPMS 0.52 12.49 0.44 3.44e-32 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs10206020 0.921 rs11884956 chr2:1566426 A/G cg12573674 chr2:1569213 NA -0.63 -14.26 -0.49 3.01e-40 IgG glycosylation; BRCA cis rs908922 0.676 rs478926 chr1:152511533 G/T cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg24209194 chr3:40518798 ZNF619 -0.38 -7.9 -0.3 1.21e-14 Renal cell carcinoma; BRCA trans rs2204008 0.569 rs11495449 chr12:37995753 C/T cg06521331 chr12:34319734 NA -0.53 -9.61 -0.36 1.57e-20 Bladder cancer; BRCA cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg17724175 chr1:150552817 MCL1 -0.33 -10.91 -0.4 1.53e-25 Urate levels; BRCA cis rs4409675 0.556 rs2064710 chr1:28231154 G/A cg23691781 chr1:28212827 C1orf38 0.32 10.56 0.39 3.89e-24 Corneal astigmatism; BRCA cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg18904891 chr8:8559673 CLDN23 0.65 12.95 0.46 3.24e-34 Obesity-related traits; BRCA cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.55 9.12 0.34 9.71e-19 Renal function-related traits (BUN); BRCA cis rs6964587 0.621 rs38798 chr7:92044539 C/A cg17063962 chr7:91808500 NA -0.49 -10.75 -0.39 6.99e-25 Breast cancer; BRCA cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg14558114 chr2:88469736 THNSL2 0.63 9.11 0.34 1.06e-18 Plasma clusterin levels; BRCA cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg17143192 chr8:8559678 CLDN23 0.54 10.34 0.38 2.71e-23 Obesity-related traits; BRCA cis rs10484885 0.878 rs72921934 chr6:90579464 T/A cg13799429 chr6:90582589 CASP8AP2 -0.76 -9.46 -0.35 5.86e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs698833 0.852 rs2241870 chr2:44549204 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.2 0.37 9.79e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs17401966 1.000 rs2229687 chr1:10473196 C/T cg19773385 chr1:10388646 KIF1B -0.39 -8.37 -0.31 3.72e-16 Hepatocellular carcinoma; BRCA cis rs9325144 0.647 rs11168104 chr12:38857616 G/T cg26384229 chr12:38710491 ALG10B -0.5 -12.11 -0.43 1.56e-30 Morning vs. evening chronotype; BRCA cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1580019 0.922 rs1466147 chr7:32486262 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.89 19.5 0.61 8.03e-67 Cognitive ability; BRCA cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg23719950 chr11:63933701 MACROD1 -0.57 -9.53 -0.35 3.2e-20 Mean platelet volume; BRCA cis rs7727544 0.684 rs611084 chr5:131709739 A/C cg07395648 chr5:131743802 NA 0.4 9.98 0.37 6.8e-22 Blood metabolite levels; BRCA cis rs17384381 0.953 rs2284797 chr1:85792383 C/T cg16011679 chr1:85725395 C1orf52 0.54 8.17 0.31 1.69e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg26384229 chr12:38710491 ALG10B 0.77 17.24 0.56 5.75e-55 Bladder cancer; BRCA cis rs11809207 0.523 rs7087 chr1:26496651 T/C cg23602478 chr1:26503979 CNKSR1 0.23 8.03 0.3 4.83e-15 Height; BRCA trans rs6598955 0.671 rs13374173 chr1:26602256 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.54 -0.52 2.08e-46 Obesity-related traits; BRCA cis rs36051895 0.623 rs7023639 chr9:5244058 A/C cg02405213 chr9:5042618 JAK2 -0.42 -8.06 -0.3 3.73e-15 Pediatric autoimmune diseases; BRCA cis rs7246657 0.722 rs2909105 chr19:38167906 A/G cg14683738 chr19:37701593 ZNF585B -0.48 -8.23 -0.31 1.04e-15 Coronary artery calcification; BRCA cis rs6964587 1.000 rs4644173 chr7:91759597 A/G cg17063962 chr7:91808500 NA 0.6 14.13 0.49 1.22e-39 Breast cancer; BRCA cis rs737337 0.623 rs4804155 chr19:11334295 C/G cg00586551 chr19:11347513 LOC55908;DOCK6 0.53 10.54 0.38 4.84e-24 HDL cholesterol;HDL cholesterol levels; BRCA cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg05347473 chr6:146136440 FBXO30 0.39 8.06 0.3 3.81e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs61931739 0.500 rs11052966 chr12:34019826 C/T cg06521331 chr12:34319734 NA -0.6 -11.91 -0.43 1.17e-29 Morning vs. evening chronotype; BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg11814155 chr7:99998594 ZCWPW1 0.58 9.8 0.36 3.16e-21 Platelet count; BRCA cis rs4679121 0.642 rs16837507 chr3:126189395 A/G cg01106040 chr3:126194903 ZXDC -0.66 -7.85 -0.3 1.72e-14 Pursuit maintenance gain; BRCA cis rs6973256 0.795 rs763643 chr7:133343243 T/A cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg07148914 chr20:33460835 GGT7 0.38 8.32 0.31 5.29e-16 Height; BRCA cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.64 0.55 6.41e-52 Bladder cancer; BRCA cis rs724568 0.546 rs724567 chr2:67942439 T/C cg17945962 chr2:67939740 NA -0.39 -9.87 -0.36 1.8e-21 Major depressive disorder (broad); BRCA cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg01283332 chr5:1856932 NA -0.36 -8.87 -0.33 7.31e-18 Cardiovascular disease risk factors; BRCA cis rs735860 0.763 rs2817111 chr6:53125700 G/C cg10236188 chr6:53219634 NA -0.38 -8.19 -0.31 1.41e-15 Glaucoma; BRCA cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.28 0.41 4.76e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs208520 0.739 rs1935894 chr6:66891434 A/G cg07460842 chr6:66804631 NA -0.94 -17.3 -0.56 2.69e-55 Exhaled nitric oxide output; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.01 -21.02 -0.64 5.52e-75 Gut microbiome composition (summer); BRCA cis rs11690935 0.694 rs312921 chr2:172567225 T/C cg13550731 chr2:172543902 DYNC1I2 -0.93 -31.0 -0.78 1.68e-129 Schizophrenia; BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg26314531 chr2:26401878 FAM59B 0.97 16.5 0.55 3.27e-51 Gut microbiome composition (summer); BRCA trans rs561341 1.000 rs530209 chr17:30315287 A/G cg20587970 chr11:113659929 NA -1.21 -22.23 -0.66 1.6e-81 Hip circumference adjusted for BMI; BRCA cis rs561341 1.000 rs576985 chr17:30323323 C/T cg23018236 chr17:30244563 NA -0.64 -10.28 -0.38 4.62e-23 Hip circumference adjusted for BMI; BRCA cis rs2637266 1.000 rs7081214 chr10:78361134 G/A cg18941641 chr10:78392320 NA 0.35 7.84 0.3 1.83e-14 Pulmonary function; BRCA cis rs75229567 0.618 rs1599745 chr12:70186029 A/G cg10114359 chr12:70132523 RAB3IP 0.64 9.84 0.36 2.31e-21 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg22920501 chr2:26401640 FAM59B 0.94 16.25 0.54 5.88e-50 Gut microbiome composition (summer); BRCA cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg12011299 chr4:100065546 ADH4 0.48 13.63 0.47 2.69e-37 Alcohol dependence; BRCA trans rs9388451 0.839 rs3799709 chr6:126078361 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.51 -11.89 -0.43 1.41e-29 Brugada syndrome; BRCA cis rs2629540 0.793 rs10794180 chr10:126449306 T/A cg08799069 chr10:126477246 METTL10 -0.54 -11.73 -0.42 6.57e-29 Cocaine dependence; BRCA cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg01262667 chr19:19385393 TM6SF2 -0.41 -10.72 -0.39 9.03e-25 Tonsillectomy; BRCA trans rs1493916 0.837 rs1027332 chr18:31410097 A/C cg15819921 chr19:927150 ARID3A -0.41 -8.07 -0.3 3.37e-15 Life satisfaction; BRCA cis rs4423214 0.879 rs1792281 chr11:71135496 G/A cg05163923 chr11:71159392 DHCR7 -0.54 -10.94 -0.4 1.17e-25 Vitamin D levels; BRCA trans rs6479891 1.000 rs9415705 chr10:65161550 A/C cg14819942 chr15:35414228 NA 0.34 8.61 0.32 5.87e-17 Arthritis (juvenile idiopathic); BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.97 -0.46 2.5e-34 Lymphocyte counts; BRCA cis rs826838 1.000 rs11168505 chr12:38939057 A/T cg26384229 chr12:38710491 ALG10B -0.77 -19.82 -0.62 1.61e-68 Heart rate; BRCA cis rs10927875 0.541 rs1048245 chr1:16341354 T/G cg22431228 chr1:16359049 CLCNKA -0.43 -9.5 -0.35 4.02e-20 Dilated cardiomyopathy; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg25036284 chr2:26402008 FAM59B 0.95 15.91 0.53 2.86e-48 Gut microbiome composition (summer); BRCA trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21659725 chr3:3221576 CRBN -0.49 -10.27 -0.38 5.09e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4664304 0.620 rs10929957 chr2:160716508 A/G cg02280532 chr2:160761244 LY75 0.35 7.81 0.3 2.28e-14 Crohn's disease;Inflammatory bowel disease; BRCA trans rs6479891 0.818 rs2393976 chr10:65253439 G/C cg14819942 chr15:35414228 NA 0.35 8.59 0.32 6.62e-17 Arthritis (juvenile idiopathic); BRCA cis rs829880 0.858 rs733180 chr12:98842588 C/T cg25150519 chr12:98850993 NA 0.62 13.79 0.48 4.51e-38 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs514406 0.792 rs481440 chr1:53344976 C/T cg24675658 chr1:53192096 ZYG11B -0.67 -15.42 -0.52 7.61e-46 Monocyte count; BRCA cis rs6087990 0.735 rs6119946 chr20:31329704 A/G cg13636640 chr20:31349939 DNMT3B -0.63 -17.66 -0.57 3.92e-57 Ulcerative colitis; BRCA trans rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05039488 chr6:79577232 IRAK1BP1 0.36 8.15 0.31 1.9e-15 Endometrial cancer; BRCA cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.49 0.5 2.52e-41 Motion sickness; BRCA cis rs7927771 0.832 rs7940536 chr11:47395240 G/A cg20307385 chr11:47447363 PSMC3 0.39 8.38 0.31 3.42e-16 Subjective well-being; BRCA cis rs3892630 0.878 rs11878394 chr19:33205844 G/C cg22980127 chr19:33182716 NUDT19 0.89 17.45 0.57 4.94e-56 Red blood cell traits; BRCA cis rs2882667 0.822 rs13187096 chr5:138404088 C/A cg04439458 chr5:138467593 SIL1 -0.42 -10.62 -0.39 2.33e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs317689 0.680 rs315140 chr12:69790780 A/T cg20891283 chr12:69753455 YEATS4 0.56 11.36 0.41 2.22e-27 Response to diuretic therapy; BRCA cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg10295955 chr4:187884368 NA 0.99 28.93 0.75 3.04e-118 Lobe attachment (rater-scored or self-reported); BRCA cis rs11679564 0.714 rs4389320 chr2:37172531 T/C cg14987922 chr2:37194071 STRN 0.43 9.33 0.35 1.73e-19 Immature fraction of reticulocytes; BRCA cis rs7412746 0.658 rs7526489 chr1:150726238 C/T cg15448220 chr1:150897856 SETDB1 0.37 8.31 0.31 5.9e-16 Melanoma; BRCA cis rs453301 0.658 rs12114954 chr8:8904862 T/G cg06636001 chr8:8085503 FLJ10661 -0.47 -9.91 -0.36 1.28e-21 Joint mobility (Beighton score); BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg19346786 chr7:2764209 NA -0.31 -8.71 -0.33 2.58e-17 Height; BRCA cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg11941060 chr3:133502564 NA -0.33 -7.84 -0.3 1.83e-14 Iron status biomarkers; BRCA cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg11366901 chr6:160182831 ACAT2 0.83 16.25 0.54 5.81e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs12579753 0.872 rs11519752 chr12:82207300 A/G cg07988820 chr12:82153109 PPFIA2 -0.48 -8.29 -0.31 6.82e-16 Resting heart rate; BRCA trans rs11098499 0.863 rs1552092 chr4:120488496 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg05347473 chr6:146136440 FBXO30 0.39 7.91 0.3 1.1e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs6546550 0.901 rs10205487 chr2:70151471 C/T cg02498382 chr2:70120550 SNRNP27 0.5 10.81 0.39 3.84e-25 Prevalent atrial fibrillation; BRCA cis rs11809207 0.523 rs2783628 chr1:26501827 A/C cg23602478 chr1:26503979 CNKSR1 0.23 7.84 0.3 1.95e-14 Height; BRCA cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg06028605 chr16:24865363 SLC5A11 0.43 9.78 0.36 3.96e-21 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6582630 0.593 rs12816835 chr12:38533304 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.2 -0.37 9.98e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs7927771 1.000 rs7947730 chr11:47786184 C/T cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg04025307 chr7:1156635 C7orf50 0.71 17.89 0.58 2.56e-58 Longevity;Endometriosis; BRCA cis rs67981189 0.896 rs2526890 chr14:71430127 A/T cg15816911 chr14:71606274 NA -0.35 -7.93 -0.3 9.74e-15 Schizophrenia; BRCA cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.81 -0.51 7.14e-43 Chronic sinus infection; BRCA trans rs1941687 0.563 rs7232237 chr18:31324934 C/T cg27147174 chr7:100797783 AP1S1 0.42 8.03 0.3 4.54e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs870825 0.616 rs4623061 chr4:185643161 A/C cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA trans rs877282 0.945 rs12776447 chr10:790625 A/G cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.08 0.34 1.34e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg18404041 chr3:52824283 ITIH1 0.43 12.56 0.44 1.76e-32 Bipolar disorder; BRCA cis rs3771570 1.000 rs62193175 chr2:242284405 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs9467773 0.620 rs2451737 chr6:26619041 T/C cg11502198 chr6:26597334 ABT1 0.57 12.09 0.43 1.82e-30 Intelligence (multi-trait analysis); BRCA cis rs11105298 0.891 rs11105313 chr12:89923376 A/T cg00757033 chr12:89920650 WDR51B -0.54 -11.37 -0.41 2.03e-27 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2066819 1.000 rs57279772 chr12:56698960 G/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs11098499 0.908 rs1002152 chr4:120273387 C/A cg09307838 chr4:120376055 NA 0.69 14.55 0.5 1.24e-41 Corneal astigmatism; BRCA cis rs7264396 0.561 rs6142474 chr20:34574914 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.5 8.92 0.33 4.68e-18 Total cholesterol levels; BRCA cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.74 0.5 1.48e-42 Colorectal cancer; BRCA cis rs12541635 0.902 rs62525696 chr8:106968703 C/T cg10147462 chr8:107024639 NA 0.37 9.71 0.36 6.9e-21 Age of smoking initiation; BRCA cis rs870825 0.932 rs28594349 chr4:185574415 G/A cg04058563 chr4:185651563 MLF1IP 0.64 10.71 0.39 1e-24 Blood protein levels; BRCA cis rs4722166 0.704 rs4321884 chr7:22741459 A/T cg05472934 chr7:22766657 IL6 0.36 8.69 0.33 3.09e-17 Lung cancer; BRCA cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg03146154 chr1:46216737 IPP 0.45 10.08 0.37 2.88e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg24692254 chr21:30365293 RNF160 0.38 8.51 0.32 1.19e-16 Pancreatic cancer; BRCA cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.6 -0.32 6.34e-17 Monocyte percentage of white cells; BRCA cis rs1865760 1.000 rs2071297 chr6:25924513 C/G cg17691542 chr6:26056736 HIST1H1C -0.52 -10.63 -0.39 1.98e-24 Height; BRCA cis rs11758351 1.000 rs74363821 chr6:26189524 G/C cg01420254 chr6:26195488 NA 0.59 9.22 0.34 4.15e-19 Gout;Renal underexcretion gout; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg22920501 chr2:26401640 FAM59B 0.91 14.2 0.49 5.51e-40 Gut microbiome composition (summer); BRCA cis rs3818285 0.515 rs12258440 chr10:111676799 C/T cg00817464 chr10:111662876 XPNPEP1 -0.36 -9.73 -0.36 5.66e-21 Superior crus of antihelix expression; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg00080972 chr5:178986291 RUFY1 -0.5 -14.28 -0.49 2.47e-40 Lung cancer; BRCA cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.76 0.39 6.26e-25 Bipolar disorder; BRCA cis rs4285028 0.948 rs73855480 chr3:121676646 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.22 0.66 1.73e-81 Platelet count; BRCA cis rs616402 0.527 rs2274985 chr1:10573867 G/A cg17425144 chr1:10567563 PEX14 0.64 16.77 0.55 1.46e-52 Breast size; BRCA cis rs1005277 0.579 rs2472183 chr10:38392495 T/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.06 -0.4 4.01e-26 Extrinsic epigenetic age acceleration; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg20007245 chr22:24372913 LOC391322 -0.55 -12.08 -0.43 2.12e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs13095912 0.719 rs7625483 chr3:185297113 T/C cg11274856 chr3:185301563 NA 0.53 12.68 0.45 5.11e-33 Systolic blood pressure; BRCA cis rs870825 0.929 rs1405941 chr4:185591518 A/C cg04058563 chr4:185651563 MLF1IP -0.64 -11.42 -0.41 1.23e-27 Blood protein levels; BRCA cis rs4566357 0.615 rs3769643 chr2:227917270 T/C cg05526886 chr2:227700861 RHBDD1 -0.4 -8.23 -0.31 1.06e-15 Coronary artery disease; BRCA cis rs9443189 0.526 rs775060 chr6:76373567 G/A cg01950844 chr6:76311363 SENP6 -0.84 -13.4 -0.47 2.89e-36 Prostate cancer; BRCA cis rs6840258 1.000 rs10516788 chr4:87960857 A/G cg08197287 chr4:87952173 AFF1 -0.46 -9.19 -0.34 5.23e-19 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs9287719 0.934 rs4629131 chr2:10744159 C/T cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs312274 0.802 rs12371725 chr12:41235555 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -7.9 -0.3 1.23e-14 Metabolite levels (X-11787); BRCA cis rs12949688 0.967 rs8064970 chr17:55824687 T/C cg12582317 chr17:55822272 NA 0.33 7.98 0.3 6.77e-15 Schizophrenia; BRCA cis rs6840360 0.615 rs62329085 chr4:152470237 G/A cg22705602 chr4:152727874 NA -0.33 -8.02 -0.3 5.22e-15 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.569 rs10476520 chr5:93058290 A/C cg25358565 chr5:93447407 FAM172A 0.7 12.23 0.44 4.77e-31 Diabetic retinopathy; BRCA cis rs1707322 0.691 rs28495425 chr1:46187320 T/G cg03146154 chr1:46216737 IPP 0.54 12.02 0.43 3.92e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.617 rs810400 chr7:66022889 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.07 -0.3 3.54e-15 Aortic root size; BRCA cis rs13046373 0.508 rs1911572 chr21:32031648 A/G cg27071517 chr21:31768726 KRTAP13-1 -0.3 -8.27 -0.31 7.72e-16 HDL cholesterol; BRCA cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg12311346 chr5:56204834 C5orf35 -0.81 -16.16 -0.54 1.7e-49 Initial pursuit acceleration; BRCA cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.81 -0.3 2.34e-14 Total body bone mineral density; BRCA cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg08807101 chr21:30365312 RNF160 -0.59 -14.68 -0.5 3.08e-42 Dental caries; BRCA cis rs4566357 0.539 rs10933164 chr2:227860671 A/G cg11843606 chr2:227700838 RHBDD1 -0.73 -14.73 -0.5 1.72e-42 Coronary artery disease; BRCA cis rs514406 0.929 rs557715 chr1:53321593 C/G cg24675658 chr1:53192096 ZYG11B -0.52 -11.62 -0.42 1.91e-28 Monocyte count; BRCA cis rs9796 0.621 rs691702 chr15:41474399 C/G cg18705301 chr15:41695430 NDUFAF1 -0.37 -7.91 -0.3 1.13e-14 Menopause (age at onset); BRCA cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg14500267 chr11:67383377 NA -0.39 -8.08 -0.3 3.24e-15 Mean corpuscular volume; BRCA cis rs7408868 0.908 rs45591935 chr19:15277006 T/C cg14696996 chr19:15285081 NOTCH3 0.99 14.48 0.5 2.74e-41 Pulse pressure; BRCA cis rs6005807 0.545 rs12169120 chr22:29005302 A/C cg12565055 chr22:29076175 TTC28 0.48 8.79 0.33 1.41e-17 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs9815354 0.767 rs79323474 chr3:42000973 C/T cg03022575 chr3:42003672 ULK4 0.73 10.08 0.37 2.94e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17270561 0.609 rs1317816 chr6:25765390 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs9467773 1.000 rs6922824 chr6:26553815 C/G cg09904177 chr6:26538194 HMGN4 -0.54 -17.53 -0.57 1.9e-56 Intelligence (multi-trait analysis); BRCA cis rs1451375 0.698 rs7797131 chr7:50647934 A/G cg18232548 chr7:50535776 DDC 0.39 9.19 0.34 5.5e-19 Malaria; BRCA cis rs13064411 0.542 rs1463643 chr3:113215447 A/G cg18753928 chr3:113234510 CCDC52 -0.46 -9.92 -0.37 1.14e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg23791538 chr6:167370224 RNASET2 -0.33 -8.02 -0.3 4.98e-15 Crohn's disease; BRCA cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.93 0.3 9.65e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10771511 1 rs10771511 chr12:29437217 T/C cg09582351 chr12:29534625 ERGIC2 -0.34 -8.33 -0.31 4.78e-16 Platelet distribution width; BRCA trans rs9858542 0.953 rs9827021 chr3:49514764 C/A cg21659725 chr3:3221576 CRBN -0.46 -9.91 -0.36 1.27e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4478858 0.709 rs3766296 chr1:31820223 G/A cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs782590 0.774 rs782629 chr2:55900283 C/T cg18811423 chr2:55921094 PNPT1 -0.78 -26.64 -0.73 1.02e-105 Metabolic syndrome; BRCA cis rs4253311 0.544 rs4253256 chr4:187159282 G/C cg24794857 chr4:187113578 CYP4V2 0.4 8.16 0.31 1.82e-15 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; BRCA cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg15395560 chr15:45543142 SLC28A2 0.3 8.29 0.31 6.44e-16 Uric acid levels; BRCA cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg22834771 chr12:69754056 YEATS4 -0.43 -10.63 -0.39 2.04e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs7408868 1.000 rs10410514 chr19:15277610 C/T cg14696996 chr19:15285081 NOTCH3 0.99 14.48 0.5 2.63e-41 Pulse pressure; BRCA cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg27347728 chr4:17578864 LAP3 0.43 7.94 0.3 9.17e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6545883 0.718 rs6715259 chr2:61851845 G/T cg15711740 chr2:61764176 XPO1 -0.46 -11.27 -0.41 5.55e-27 Tuberculosis; BRCA cis rs68170813 0.559 rs12536491 chr7:106978024 T/G cg02696742 chr7:106810147 HBP1 -0.55 -8.79 -0.33 1.4e-17 Coronary artery disease; BRCA cis rs8062405 1.000 rs62036620 chr16:28833097 A/G cg09754948 chr16:28834200 ATXN2L 0.46 9.12 0.34 9.55e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2625529 0.652 rs2930069 chr15:72226977 G/A cg16672083 chr15:72433130 SENP8 0.65 15.64 0.53 6.25e-47 Red blood cell count; BRCA cis rs4595586 0.545 rs12812262 chr12:39392567 T/A cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs11229555 1.000 rs11603890 chr11:58402251 T/C cg15696309 chr11:58395628 NA -0.52 -11.48 -0.41 6.93e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg09060608 chr5:178986726 RUFY1 0.45 9.44 0.35 7.1e-20 Lung cancer; BRCA cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg00530320 chr1:46809349 NSUN4 0.48 9.42 0.35 8.15e-20 Menopause (age at onset); BRCA cis rs61931739 0.500 rs10844829 chr12:34304916 G/T cg06521331 chr12:34319734 NA -0.65 -11.99 -0.43 5.16e-30 Morning vs. evening chronotype; BRCA cis rs317689 0.918 rs689415 chr12:69738139 A/G cg20891283 chr12:69753455 YEATS4 -0.51 -10.12 -0.37 1.9e-22 Response to diuretic therapy; BRCA cis rs10193935 0.901 rs6720837 chr2:42463173 A/T cg27598129 chr2:42591480 NA -0.6 -9.96 -0.37 7.74e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs9309473 1.000 rs56154726 chr2:73721767 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -10.74 -0.39 7.36e-25 Metabolite levels; BRCA cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg25019033 chr10:957182 NA -0.41 -7.85 -0.3 1.75e-14 Eosinophil percentage of granulocytes; BRCA cis rs9527 0.590 rs726010 chr10:104841977 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.09 0.37 2.57e-22 Arsenic metabolism; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg21747090 chr2:27597821 SNX17 -0.45 -9.65 -0.36 1.2e-20 Menopause (age at onset); BRCA cis rs2797160 1.000 rs9321050 chr6:126001568 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.42 -0.35 8.36e-20 Endometrial cancer; BRCA cis rs78366141 0.649 rs7666372 chr4:89687531 C/T cg01026744 chr4:89619053 NAP1L5;HERC3 0.78 7.9 0.3 1.23e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs7103648 0.669 rs12577383 chr11:47774238 C/T cg03711944 chr11:47377212 SPI1 -0.39 -9.25 -0.34 3.28e-19 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs7826238 0.502 rs10503377 chr8:8378422 C/T cg06636001 chr8:8085503 FLJ10661 0.53 9.57 0.35 2.22e-20 Systolic blood pressure; BRCA cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg11663144 chr21:46675770 NA 0.45 10.78 0.39 5.31e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg04944784 chr2:26401820 FAM59B 0.99 16.67 0.55 4.32e-52 Gut microbiome composition (summer); BRCA cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg20224285 chr3:52813920 ITIH1 0.32 8.0 0.3 5.68e-15 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11890956 chr21:40555474 PSMG1 -0.83 -19.97 -0.62 2.55e-69 Cognitive function; BRCA cis rs2016266 0.964 rs2272313 chr12:53671549 A/G cg26875137 chr12:53738046 NA 0.36 9.59 0.35 2e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs3772130 0.540 rs57791671 chr3:121608433 T/A cg20356878 chr3:121714668 ILDR1 0.42 9.55 0.35 2.81e-20 Cognitive performance; BRCA cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg15448220 chr1:150897856 SETDB1 0.35 7.99 0.3 6.1e-15 Melanoma; BRCA cis rs7267979 1.000 rs6083828 chr20:25369918 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.85 -0.33 8.7e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg05347473 chr6:146136440 FBXO30 0.44 8.66 0.32 3.75e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg14829155 chr15:31115871 NA -0.43 -9.9 -0.36 1.4e-21 Huntington's disease progression; BRCA cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.52 -0.32 1.14e-16 Total body bone mineral density; BRCA cis rs868036 0.522 rs3784711 chr15:68072527 C/T cg08079166 chr15:68083412 MAP2K5 -0.32 -8.57 -0.32 7.75e-17 Restless legs syndrome; BRCA cis rs503734 0.521 rs546105 chr3:100967920 A/G cg27318481 chr3:100970896 IMPG2 -0.34 -8.19 -0.31 1.41e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg06028605 chr16:24865363 SLC5A11 0.39 8.15 0.31 1.96e-15 Intelligence (multi-trait analysis); BRCA cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg13073564 chr4:8508604 NA 0.43 11.8 0.42 3.31e-29 Response to antineoplastic agents; BRCA cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg25019033 chr10:957182 NA -0.41 -7.86 -0.3 1.63e-14 Eosinophil percentage of granulocytes; BRCA cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.62 -15.03 -0.51 6.11e-44 Hemoglobin concentration; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg06115741 chr20:33292138 TP53INP2 0.47 10.63 0.39 2.05e-24 Coronary artery disease; BRCA cis rs11608355 0.515 rs12579916 chr12:109924528 T/G cg05360138 chr12:110035743 NA 0.72 13.17 0.46 3.38e-35 Neuroticism; BRCA cis rs559928 0.606 rs55970968 chr11:63961433 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.62 0.42 1.89e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs4660306 1.000 rs4660306 chr1:45978675 C/T cg24296786 chr1:45957014 TESK2 -0.45 -9.07 -0.34 1.43e-18 Homocysteine levels; BRCA cis rs965469 0.779 rs6139092 chr20:3334651 T/C cg25506879 chr20:3388711 C20orf194 -0.42 -8.1 -0.31 2.81e-15 IFN-related cytopenia; BRCA cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg07636037 chr3:49044803 WDR6 0.97 29.12 0.76 2.84e-119 Parkinson's disease; BRCA trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg03929089 chr4:120376271 NA 0.57 9.25 0.34 3.26e-19 Axial length; BRCA cis rs7677751 0.806 rs67432867 chr4:55104454 A/T cg17187183 chr4:55093834 PDGFRA 0.44 9.1 0.34 1.14e-18 Corneal astigmatism; BRCA cis rs6121246 0.559 rs1484994 chr20:30305975 A/G cg21427119 chr20:30132790 HM13 -0.36 -8.1 -0.31 2.87e-15 Mean corpuscular hemoglobin; BRCA cis rs7666738 0.830 rs1426668 chr4:98945585 T/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1400816 0.850 rs59414074 chr2:172535198 C/T cg13550731 chr2:172543902 DYNC1I2 0.5 8.55 0.32 9.26e-17 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.34 -0.31 4.64e-16 Total body bone mineral density; BRCA cis rs751728 0.664 rs2395402 chr6:33753673 G/A cg25922239 chr6:33757077 LEMD2 0.5 12.67 0.45 5.49e-33 Crohn's disease; BRCA trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg22491629 chr6:157744540 C6orf35 -0.67 -12.32 -0.44 1.87e-31 Hemostatic factors and hematological phenotypes; BRCA cis rs6901250 1.000 rs6924002 chr6:117114223 A/T cg12892004 chr6:117198278 RFX6 0.48 10.7 0.39 1.1e-24 C-reactive protein levels; BRCA cis rs9291683 0.669 rs887733 chr4:10183108 T/C cg11266682 chr4:10021025 SLC2A9 -0.34 -8.39 -0.32 3.1e-16 Bone mineral density; BRCA cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg00071950 chr4:10020882 SLC2A9 0.64 15.64 0.53 6.38e-47 Bone mineral density; BRCA cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg01579765 chr21:45077557 HSF2BP 0.42 11.76 0.42 5.09e-29 Mean corpuscular volume; BRCA cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg07148914 chr20:33460835 GGT7 -0.43 -9.18 -0.34 5.73e-19 Height; BRCA cis rs3008870 1.000 rs2755246 chr1:67488984 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.93 20.6 0.63 1.04e-72 Lymphocyte percentage of white cells; BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00149659 chr3:10157352 C3orf10 -0.64 -11.21 -0.41 9.21e-27 Alzheimer's disease; BRCA cis rs6840360 0.615 rs72728179 chr4:152477877 A/G cg22705602 chr4:152727874 NA -0.32 -8.02 -0.3 5.2e-15 Intelligence (multi-trait analysis); BRCA cis rs9649465 0.967 rs6944031 chr7:123299304 T/C cg04330084 chr7:123175371 IQUB -0.31 -8.64 -0.32 4.54e-17 Migraine; BRCA cis rs12611088 0.571 rs8110232 chr19:44027390 T/C cg13740135 chr19:44006432 PHLDB3 -0.3 -7.84 -0.3 1.83e-14 Plasma amyloid beta peptide concentrations (ABx-42); BRCA trans rs6461049 0.765 rs1476887 chr7:2151633 T/C cg04565464 chr8:145669602 NFKBIL2 0.46 10.91 0.4 1.51e-25 Schizophrenia; BRCA cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.57e-23 Motion sickness; BRCA cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg00031303 chr3:195681400 NA 0.46 8.6 0.32 6.13e-17 Pancreatic cancer; BRCA cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs6011368 0.740 rs6062357 chr20:62892739 C/T cg13869341 chr1:15865 WASH5P 0.37 8.38 0.31 3.31e-16 Clozapine-induced cytotoxicity; BRCA cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg24642439 chr20:33292090 TP53INP2 0.45 9.82 0.36 2.68e-21 Glomerular filtration rate (creatinine); BRCA cis rs7267979 1.000 rs6115182 chr20:25410259 G/A cg08601574 chr20:25228251 PYGB -0.33 -7.83 -0.3 1.99e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg23711669 chr6:146136114 FBXO30 0.8 19.0 0.6 3.7e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg20503657 chr10:835505 NA 0.61 10.44 0.38 1.14e-23 Eosinophil percentage of granulocytes; BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.37 -8.21 -0.31 1.2e-15 Tonsillectomy; BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg21747090 chr2:27597821 SNX17 -0.37 -7.89 -0.3 1.33e-14 Total body bone mineral density; BRCA cis rs8077889 0.956 rs6503476 chr17:41850163 C/T cg26893861 chr17:41843967 DUSP3 0.78 15.54 0.52 2.02e-46 Triglycerides; BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.2 0.34 5.09e-19 Tonsillectomy; BRCA cis rs12618769 0.597 rs12622341 chr2:99074680 A/T cg10123293 chr2:99228465 UNC50 0.41 7.9 0.3 1.21e-14 Bipolar disorder; BRCA cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg21475434 chr5:93447410 FAM172A 0.69 8.58 0.32 6.97e-17 Diabetic retinopathy; BRCA cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg06026331 chr20:60912101 LAMA5 -0.58 -11.49 -0.41 6.83e-28 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs208520 0.661 rs6937856 chr6:66867468 A/G cg07460842 chr6:66804631 NA -1.0 -19.6 -0.61 2.47e-67 Exhaled nitric oxide output; BRCA cis rs6840258 0.660 rs17012213 chr4:87889167 G/T cg08197287 chr4:87952173 AFF1 -0.46 -8.4 -0.32 2.8e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg02733842 chr7:1102375 C7orf50 -0.61 -11.38 -0.41 1.83e-27 Bronchopulmonary dysplasia; BRCA cis rs7975161 0.753 rs7972034 chr12:104640881 G/T cg25273343 chr12:104657179 TXNRD1 -0.6 -9.31 -0.35 2.1e-19 Toenail selenium levels; BRCA cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg07606381 chr6:8435919 SLC35B3 0.64 14.02 0.48 4.01e-39 Motion sickness; BRCA cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg04034577 chr2:241836375 C2orf54 -0.56 -13.8 -0.48 3.98e-38 Urinary metabolites; BRCA cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg18132916 chr6:79620363 NA -0.5 -11.42 -0.41 1.29e-27 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.64 10.41 0.38 1.47e-23 Renal function-related traits (BUN); BRCA cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg05347473 chr6:146136440 FBXO30 0.6 11.55 0.42 3.69e-28 Lobe attachment (rater-scored or self-reported); BRCA trans rs2235573 0.527 rs139887 chr22:38371396 G/C cg19894588 chr14:64061835 NA 0.35 8.55 0.32 9.11e-17 Glioblastoma;Glioma; BRCA cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg05340658 chr4:99064831 C4orf37 0.69 17.11 0.56 2.48e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.943 rs13343502 chr19:37962292 C/T cg18154014 chr19:37997991 ZNF793 0.62 11.75 0.42 5.29e-29 Coronary artery calcification; BRCA cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg13906792 chr15:75199810 C15orf17 -0.4 -9.28 -0.34 2.59e-19 Breast cancer; BRCA cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs870825 1.000 rs870823 chr4:185588195 G/A cg20176042 chr4:185552304 CASP3 -0.58 -7.9 -0.3 1.24e-14 Blood protein levels; BRCA cis rs16870629 1.000 rs16870629 chr5:1015063 C/T cg00278107 chr5:1061253 SLC12A7 -0.72 -14.48 -0.5 2.62e-41 QT interval; BRCA cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.41 -0.32 2.58e-16 Intelligence (multi-trait analysis); BRCA cis rs6424115 0.644 rs2267960 chr1:24068544 T/C cg10978503 chr1:24200527 CNR2 0.34 8.0 0.3 5.73e-15 Immature fraction of reticulocytes; BRCA cis rs4919694 1.000 rs12261040 chr10:104665397 T/C cg04362960 chr10:104952993 NT5C2 0.93 14.99 0.51 9.22e-44 Arsenic metabolism; BRCA cis rs4363385 0.617 rs5010885 chr1:152973141 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.26 -0.31 8.37e-16 Inflammatory skin disease; BRCA cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg13073564 chr4:8508604 NA 0.31 8.03 0.3 4.8e-15 Response to antineoplastic agents; BRCA cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg20701182 chr2:24300061 SF3B14 0.57 8.69 0.33 3.09e-17 Lymphocyte counts; BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.26 -0.49 3e-40 Platelet count; BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg08280861 chr8:58055591 NA 0.45 8.03 0.3 4.83e-15 Developmental language disorder (linguistic errors); BRCA cis rs9814567 1.000 rs62271513 chr3:134298412 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.33 0.61 6.33e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg08470875 chr2:26401718 FAM59B 0.77 11.95 0.43 7.7e-30 Gut microbiome composition (summer); BRCA cis rs6028335 0.674 rs16987712 chr20:37601243 A/G cg16355469 chr20:37678765 NA 0.44 8.01 0.3 5.34e-15 Alcohol and nicotine co-dependence; BRCA cis rs3820928 0.874 rs6728239 chr2:227856552 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.46e-16 Pulmonary function; BRCA cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg15128208 chr22:42549153 NA 0.32 8.24 0.31 1.01e-15 Cognitive function; BRCA cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.48 -9.83 -0.36 2.49e-21 Tonsillectomy; BRCA cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg06636001 chr8:8085503 FLJ10661 0.56 11.53 0.42 4.34e-28 Mood instability; BRCA cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.36 -0.31 3.99e-16 Bipolar disorder; BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg20203395 chr5:56204925 C5orf35 -0.41 -9.25 -0.34 3.32e-19 Initial pursuit acceleration; BRCA cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg08885076 chr2:99613938 TSGA10 0.43 10.22 0.37 8.29e-23 Chronic sinus infection; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg09658497 chr7:2847517 GNA12 -0.42 -8.01 -0.3 5.43e-15 Height; BRCA cis rs9527 0.545 rs12247514 chr10:104958066 C/A cg04362960 chr10:104952993 NT5C2 0.43 9.57 0.35 2.35e-20 Arsenic metabolism; BRCA cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2594714 0.538 rs895819 chr19:13947292 A/G cg18576835 chr19:13944261 NA -0.41 -11.58 -0.42 2.81e-28 Breast cancer; BRCA cis rs600806 0.850 rs115935180 chr1:109976775 C/G cg20591472 chr1:110008990 SYPL2 0.33 8.38 0.31 3.37e-16 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.64 -0.36 1.23e-20 Alcohol dependence; BRCA cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg10295955 chr4:187884368 NA -0.97 -28.47 -0.75 9.28e-116 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.966 rs2261784 chr20:25262396 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.72 0.36 6.56e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg01579765 chr21:45077557 HSF2BP -0.4 -10.74 -0.39 7.53e-25 Mean corpuscular volume; BRCA cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg21132104 chr15:45694354 SPATA5L1 0.75 16.48 0.55 4.24e-51 Homoarginine levels; BRCA cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg12573674 chr2:1569213 NA -0.51 -9.54 -0.35 2.88e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1801251 0.928 rs737028 chr2:233640750 T/C cg08000102 chr2:233561755 GIGYF2 0.63 13.89 0.48 1.61e-38 Coronary artery disease; BRCA cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.42 -8.95 -0.33 3.96e-18 IgG glycosylation; BRCA cis rs1949733 0.598 rs16842480 chr4:8535621 G/T cg11789530 chr4:8429930 ACOX3 -0.56 -13.3 -0.47 7.97e-36 Response to antineoplastic agents; BRCA cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg11764359 chr7:65958608 NA -0.78 -17.83 -0.58 5.07e-58 Aortic root size; BRCA cis rs694739 0.628 rs645078 chr11:64135298 A/C cg26898376 chr11:64110657 CCDC88B 0.36 7.88 0.3 1.44e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg10523679 chr1:76189770 ACADM 0.68 13.47 0.47 1.37e-36 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 9.15 0.34 7.46e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs9467773 1.000 rs9467778 chr6:26534743 T/C cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -8.3 -0.31 6.43e-16 Total body bone mineral density; BRCA cis rs3087591 1.000 rs7226006 chr17:29650656 A/G cg24425628 chr17:29625626 OMG;NF1 -0.44 -9.05 -0.34 1.69e-18 Hip circumference; BRCA cis rs11662586 0.517 rs7230837 chr18:77695384 A/T cg20368463 chr18:77673604 PQLC1 0.46 11.73 0.42 6.66e-29 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.36 -0.38 2.35e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7615952 0.576 rs66671308 chr3:125793526 T/G cg07211511 chr3:129823064 LOC729375 -0.63 -11.09 -0.4 2.86e-26 Blood pressure (smoking interaction); BRCA cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg12863693 chr15:85201151 NMB -0.36 -8.55 -0.32 9.38e-17 P wave terminal force; BRCA cis rs7246657 0.765 rs10402455 chr19:37728707 G/A cg14683738 chr19:37701593 ZNF585B 0.54 8.42 0.32 2.48e-16 Coronary artery calcification; BRCA cis rs11250464 0.794 rs11250487 chr10:1434168 C/A cg08668359 chr10:1443807 ADARB2 0.5 9.56 0.35 2.51e-20 Radiation response; BRCA cis rs2180341 0.842 rs6569476 chr6:127553539 G/A cg27446573 chr6:127587934 RNF146 0.8 15.56 0.52 1.5e-46 Breast cancer; BRCA cis rs477895 0.713 rs882146 chr11:63976699 G/A cg18225595 chr11:63971243 STIP1 0.54 9.66 0.36 1.07e-20 Mean platelet volume; BRCA cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg19784903 chr17:45786737 TBKBP1 0.34 8.3 0.31 6.1e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2011503 0.714 rs113980591 chr19:19565357 G/A cg11584989 chr19:19387371 SF4 0.63 12.67 0.45 5.37e-33 Bipolar disorder; BRCA cis rs208515 0.560 rs207084 chr6:66776966 T/C cg07460842 chr6:66804631 NA -1.09 -31.58 -0.78 1.37e-132 Exhaled nitric oxide levels; BRCA cis rs4953076 0.573 rs6734443 chr2:44408282 G/C cg04920474 chr2:44395004 PPM1B 0.51 10.4 0.38 1.66e-23 Height; BRCA cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg12072164 chr19:44306565 LYPD5 0.44 9.76 0.36 4.68e-21 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.81 12.49 0.44 3.53e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg14847009 chr1:175162515 KIAA0040 0.24 9.05 0.34 1.72e-18 Alcohol dependence; BRCA cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg03146154 chr1:46216737 IPP 0.52 11.27 0.41 5.52e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2243480 0.615 rs34363376 chr7:65939536 T/C cg18252515 chr7:66147081 NA -1.07 -15.88 -0.53 3.98e-48 Diabetic kidney disease; BRCA cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg03433033 chr1:76189801 ACADM 0.68 13.08 0.46 8.56e-35 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4689388 0.890 rs4688991 chr4:6302220 C/G cg00701064 chr4:6280414 WFS1 0.7 19.38 0.61 3.64e-66 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7474896 0.583 rs10740950 chr10:38003496 C/T cg25427524 chr10:38739819 LOC399744 -0.54 -9.5 -0.35 3.97e-20 Obesity (extreme); BRCA cis rs12458462 1.000 rs12458462 chr18:77472436 C/A cg11879182 chr18:77439856 CTDP1 0.62 12.85 0.45 8.51e-34 Monocyte count; BRCA cis rs11105298 0.838 rs4842488 chr12:89881564 C/G cg00757033 chr12:89920650 WDR51B 0.53 10.7 0.39 1.13e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg18402987 chr7:1209562 NA 0.43 8.72 0.33 2.37e-17 Longevity;Endometriosis; BRCA cis rs1949733 0.701 rs940134 chr4:8454870 C/T cg11789530 chr4:8429930 ACOX3 0.59 14.72 0.5 1.85e-42 Response to antineoplastic agents; BRCA cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg18305652 chr10:134549665 INPP5A 0.49 11.17 0.4 1.39e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.62 12.9 0.45 5.52e-34 Monocyte percentage of white cells; BRCA trans rs6479891 1.000 rs12415038 chr10:65160858 A/G cg14819942 chr15:35414228 NA 0.35 8.67 0.32 3.63e-17 Arthritis (juvenile idiopathic); BRCA trans rs629535 0.911 rs490165 chr8:70014976 A/G cg21567404 chr3:27674614 NA -0.93 -19.74 -0.62 4.33e-68 Dupuytren's disease; BRCA cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.85 -0.3 1.81e-14 Aortic root size; BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg05863683 chr7:1912471 MAD1L1 -0.41 -9.7 -0.36 7.6e-21 Bipolar disorder and schizophrenia; BRCA trans rs11098499 0.697 rs10020027 chr4:120381879 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.3e-14 Corneal astigmatism; BRCA cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg18252515 chr7:66147081 NA -0.57 -11.42 -0.41 1.27e-27 Corneal structure; BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.7 0.57 2.51e-57 Platelet count; BRCA cis rs875971 0.502 rs2465121 chr7:65621004 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.56 -10.3 -0.38 4.02e-23 Aortic root size; BRCA cis rs12310956 0.532 rs10844712 chr12:33961022 G/A cg06521331 chr12:34319734 NA -0.57 -11.13 -0.4 1.93e-26 Morning vs. evening chronotype; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg11843238 chr5:131593191 PDLIM4 0.41 10.35 0.38 2.63e-23 Acylcarnitine levels; BRCA cis rs909002 0.789 rs3817398 chr1:32119431 C/T cg11573219 chr1:32083031 HCRTR1 -0.29 -9.26 -0.34 3.05e-19 Intelligence (multi-trait analysis); BRCA cis rs2635047 1.000 rs2684825 chr18:44666415 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 8.13 0.31 2.25e-15 Educational attainment; BRCA cis rs7635838 0.654 rs346086 chr3:11272932 G/T cg00170343 chr3:11313890 ATG7 0.43 8.37 0.31 3.53e-16 HDL cholesterol; BRCA cis rs7592578 0.679 rs62181019 chr2:191325414 A/G cg11845111 chr2:191398756 TMEM194B -0.69 -13.52 -0.47 8.46e-37 Diastolic blood pressure; BRCA cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.53 -0.44 2.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg13114125 chr14:105738426 BRF1 -0.48 -10.26 -0.38 5.53e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs10911251 0.508 rs2296297 chr1:183105324 C/T ch.1.3577855R chr1:183094577 LAMC1 0.65 16.88 0.56 3.96e-53 Colorectal cancer; BRCA cis rs262150 0.851 rs2730249 chr7:158767628 A/G cg19418458 chr7:158789849 NA 0.41 9.39 0.35 1e-19 Facial morphology (factor 20); BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.55 -10.96 -0.4 9.86e-26 Lymphocyte counts; BRCA cis rs6456156 0.586 rs12527827 chr6:167469271 C/T cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs6598955 0.671 rs11247900 chr1:26612460 G/A cg04990556 chr1:26633338 UBXN11 0.54 9.04 0.34 1.84e-18 Obesity-related traits; BRCA cis rs61931739 0.517 rs7975714 chr12:34055611 T/C cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.44e-26 Morning vs. evening chronotype; BRCA cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg24549020 chr5:56110836 MAP3K1 -0.39 -8.19 -0.31 1.48e-15 Initial pursuit acceleration; BRCA cis rs7246657 0.943 rs10417503 chr19:37842735 T/C cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg22974920 chr21:40686053 BRWD1 -0.37 -8.35 -0.31 4.26e-16 Cognitive function; BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg04944784 chr2:26401820 FAM59B -0.69 -11.41 -0.41 1.37e-27 Gut microbiome composition (summer); BRCA cis rs9658691 0.607 rs9658750 chr10:90766596 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.55 -8.01 -0.3 5.34e-15 Mosquito bite size; BRCA cis rs4713118 0.616 rs9348789 chr6:28025486 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs1878931 0.580 rs3848355 chr16:3407489 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 22.77 0.67 1.65e-84 Body mass index (adult); BRCA cis rs270601 0.913 rs273916 chr5:131659830 C/A cg11843238 chr5:131593191 PDLIM4 0.35 7.85 0.3 1.77e-14 Acylcarnitine levels; BRCA cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.58 -0.32 7.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs495337 0.736 rs596195 chr20:48474768 T/C cg17835207 chr20:48524531 SPATA2 -0.5 -10.94 -0.4 1.24e-25 Psoriasis; BRCA cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.53 -10.17 -0.37 1.32e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.99 14.82 0.51 6.43e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs61931739 0.534 rs1817761 chr12:34105719 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.23 0.34 3.94e-19 Morning vs. evening chronotype; BRCA cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.29 -0.41 4.58e-27 Schizophrenia; BRCA trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg16141378 chr3:129829833 LOC729375 0.32 7.9 0.3 1.21e-14 Neuroticism; BRCA cis rs10193935 1.000 rs10185742 chr2:42429666 A/G cg27598129 chr2:42591480 NA -0.96 -15.3 -0.52 2.9e-45 Colonoscopy-negative controls vs population controls; BRCA trans rs1994135 0.608 rs1482994 chr12:33713631 T/C cg13010199 chr12:38710504 ALG10B 0.42 7.89 0.3 1.33e-14 Resting heart rate; BRCA cis rs6963495 0.556 rs711433 chr7:105153191 A/G cg19920283 chr7:105172520 RINT1 -0.43 -8.89 -0.33 6e-18 Bipolar disorder (body mass index interaction); BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg10729496 chr3:10149963 C3orf24 0.48 8.93 0.33 4.51e-18 Alzheimer's disease; BRCA cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg06808227 chr14:105710500 BRF1 -0.79 -16.08 -0.54 4.34e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg08219700 chr8:58056026 NA 0.47 8.51 0.32 1.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs7395581 0.918 rs4752824 chr11:47324666 A/T cg25783544 chr11:47291846 MADD 0.43 9.71 0.36 6.74e-21 HDL cholesterol; BRCA cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg21132104 chr15:45694354 SPATA5L1 0.76 17.06 0.56 4.53e-54 Homoarginine levels; BRCA trans rs7615952 0.599 rs12485717 chr3:125707075 C/T cg07211511 chr3:129823064 LOC729375 0.55 9.49 0.35 4.63e-20 Blood pressure (smoking interaction); BRCA cis rs243505 1.000 rs243520 chr7:148423560 C/T cg09806900 chr7:148480153 CUL1 -0.43 -8.68 -0.32 3.19e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg11752832 chr7:134001865 SLC35B4 0.5 12.74 0.45 2.81e-33 Mean platelet volume; BRCA cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg02659138 chr7:134003124 SLC35B4 0.34 10.72 0.39 9.27e-25 Mean platelet volume; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg21143896 chr7:2802374 GNA12 -0.38 -9.55 -0.35 2.69e-20 Height; BRCA cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg16179182 chr5:140090404 VTRNA1-1 0.46 10.91 0.4 1.6e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs9790314 0.875 rs7615592 chr3:160981548 A/C cg03342759 chr3:160939853 NMD3 -0.64 -13.47 -0.47 1.34e-36 Morning vs. evening chronotype; BRCA trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg11887960 chr12:57824829 NA 0.49 8.21 0.31 1.22e-15 Lung disease severity in cystic fibrosis; BRCA cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg12437481 chr16:420112 MRPL28 -0.6 -15.24 -0.52 6.05e-45 Bone mineral density (spine);Bone mineral density; BRCA cis rs12458462 0.851 rs3859317 chr18:77443093 A/C cg11879182 chr18:77439856 CTDP1 0.64 13.91 0.48 1.33e-38 Monocyte count; BRCA cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg11764359 chr7:65958608 NA -0.77 -17.55 -0.57 1.38e-56 Aortic root size; BRCA cis rs7772486 0.713 rs79248977 chr6:146319388 C/A cg13319975 chr6:146136371 FBXO30 -0.38 -8.37 -0.31 3.51e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs586533 0.813 rs642881 chr11:99502807 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.45e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18758796 chr5:131593413 PDLIM4 0.39 9.94 0.37 9.96e-22 Acylcarnitine levels; BRCA cis rs10193935 1.000 rs10180528 chr2:42436723 T/A cg27598129 chr2:42591480 NA -0.92 -15.03 -0.51 5.82e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs11634851 1.000 rs4630510 chr15:81032822 C/T cg03950166 chr15:80988613 FAM108C1 -0.35 -7.93 -0.3 9.69e-15 Systolic blood pressure; BRCA cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg10523679 chr1:76189770 ACADM -0.73 -14.94 -0.51 1.75e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs5758659 0.652 rs133313 chr22:42401749 G/T cg15557168 chr22:42548783 NA -0.31 -8.66 -0.32 3.9e-17 Cognitive function; BRCA cis rs6723226 0.650 rs6729952 chr2:32764922 T/C cg02381751 chr2:32503542 YIPF4 0.55 12.04 0.43 3.12e-30 Intelligence (multi-trait analysis); BRCA cis rs7715811 0.913 rs73749952 chr5:13762518 T/C cg07548982 chr5:13769939 DNAH5 -0.37 -7.99 -0.3 6.24e-15 Subclinical atherosclerosis traits (other); BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.41 -0.41 1.37e-27 Gut microbiome composition (summer); BRCA cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -12.01 -0.43 4.18e-30 Chronic sinus infection; BRCA cis rs12612619 0.732 rs2304681 chr2:27315252 G/A cg00617064 chr2:27272375 NA 0.34 8.39 0.32 3.02e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg01849466 chr14:104193079 ZFYVE21 0.46 10.87 0.39 2.31e-25 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs11690935 0.959 rs10207085 chr2:172585885 T/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.79 -0.77 2.53e-128 Schizophrenia; BRCA cis rs1113500 0.580 rs1781058 chr1:108564059 C/G cg06207961 chr1:108661230 NA 0.35 8.14 0.31 2.09e-15 Growth-regulated protein alpha levels; BRCA cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg00531865 chr16:30841666 NA -0.41 -9.87 -0.36 1.69e-21 Dementia with Lewy bodies; BRCA cis rs68170813 0.596 rs76888321 chr7:106945926 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.88 -0.33 6.49e-18 Coronary artery disease; BRCA cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg13010199 chr12:38710504 ALG10B 0.45 9.38 0.35 1.16e-19 Bladder cancer; BRCA cis rs7586879 0.828 rs7597157 chr2:25089166 C/T cg04586622 chr2:25135609 ADCY3 0.38 9.16 0.34 7.06e-19 Body mass index; BRCA cis rs1003719 0.715 rs4261789 chr21:38503762 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.15 -0.49 9.86e-40 Eye color traits; BRCA cis rs11098499 0.863 rs28718422 chr4:120466304 C/A cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs4363385 0.818 rs12085426 chr1:153003074 C/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.44 -0.32 2.11e-16 Inflammatory skin disease; BRCA cis rs2806561 0.514 rs11801120 chr1:23543307 C/T cg19743168 chr1:23544995 NA 0.68 16.93 0.56 2.04e-53 Height; BRCA cis rs11955398 0.716 rs10939860 chr5:59999360 C/T cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.42e-19 Intelligence (multi-trait analysis); BRCA cis rs2806561 0.765 rs652783 chr1:23514313 G/T cg12483005 chr1:23474871 LUZP1 0.44 9.89 0.36 1.43e-21 Height; BRCA cis rs4689388 0.926 rs3889821 chr4:6282596 C/T cg25554036 chr4:6271136 WFS1 0.41 10.06 0.37 3.45e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4363385 0.747 rs4845334 chr1:152982998 T/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.15 -0.34 7.34e-19 Inflammatory skin disease; BRCA cis rs1163251 0.902 rs639761 chr1:120217558 G/A cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg10802521 chr3:52805072 NEK4 -0.34 -9.43 -0.35 7.6e-20 Bipolar disorder; BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg22535103 chr8:58192502 C8orf71 -0.46 -8.16 -0.31 1.74e-15 Developmental language disorder (linguistic errors); BRCA trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21659725 chr3:3221576 CRBN 0.69 20.42 0.63 9.85e-72 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg24110177 chr3:50126178 RBM5 0.37 10.1 0.37 2.45e-22 Menarche (age at onset); BRCA cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg17971929 chr21:40555470 PSMG1 -0.6 -13.26 -0.46 1.25e-35 Cognitive function; BRCA cis rs17270561 0.609 rs1179086 chr6:25791745 A/T cg17691542 chr6:26056736 HIST1H1C 0.43 9.27 0.34 2.89e-19 Iron status biomarkers; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg21782813 chr7:2030301 MAD1L1 0.42 11.98 0.43 5.44e-30 Bipolar disorder and schizophrenia; BRCA cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg07636037 chr3:49044803 WDR6 0.98 28.99 0.75 1.42e-118 Parkinson's disease; BRCA cis rs703842 0.575 rs701006 chr12:58106836 C/T cg18357645 chr12:58087776 OS9 -0.39 -11.25 -0.41 6.53e-27 Multiple sclerosis; BRCA cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg01483505 chr11:975446 AP2A2 0.3 7.99 0.3 6.46e-15 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg05340658 chr4:99064831 C4orf37 -0.68 -16.95 -0.56 1.75e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg15105969 chr2:36825350 FEZ2 -0.4 -7.85 -0.3 1.72e-14 Height; BRCA cis rs6570726 0.935 rs414646 chr6:145831685 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs2041840 0.538 rs2372998 chr2:37573556 G/A cg25727520 chr2:37576821 QPCT -0.29 -8.13 -0.31 2.23e-15 Chronic lymphocytic leukemia; BRCA cis rs700651 0.786 rs58224025 chr2:198821988 G/A cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.47e-21 Intracranial aneurysm; BRCA cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 2.97e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg25358565 chr5:93447407 FAM172A 1.21 18.79 0.6 5.1e-63 Diabetic retinopathy; BRCA trans rs208520 0.634 rs3909071 chr6:66836947 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.69 -0.63 3.65e-73 Exhaled nitric oxide output; BRCA cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg23283495 chr1:209979779 IRF6 -0.38 -9.07 -0.34 1.46e-18 Cleft lip with or without cleft palate; BRCA cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg16339924 chr4:17578868 LAP3 0.71 16.78 0.55 1.18e-52 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg16506815 chr2:162101123 NA 0.72 18.09 0.58 2.31e-59 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs3806843 0.900 rs2531340 chr5:140131046 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.16 0.34 7.11e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg12011299 chr4:100065546 ADH4 0.41 10.23 0.38 7.27e-23 Alcohol dependence; BRCA trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.95 -0.3 8.63e-15 Corneal astigmatism; BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg00814883 chr7:100076585 TSC22D4 -0.54 -11.59 -0.42 2.56e-28 Platelet count; BRCA cis rs6433895 0.677 rs34825850 chr2:182005326 C/A cg00481216 chr2:181971175 NA 0.46 8.68 0.32 3.35e-17 Lymphocyte counts; BRCA cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06022373 chr22:39101656 GTPBP1 0.71 17.15 0.56 1.56e-54 Menopause (age at onset); BRCA cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg06064525 chr11:970664 AP2A2 -0.28 -8.21 -0.31 1.24e-15 Alzheimer's disease (late onset); BRCA cis rs910316 0.967 rs175451 chr14:75589729 C/T cg11812906 chr14:75593930 NEK9 -0.61 -13.89 -0.48 1.55e-38 Height; BRCA cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg24829409 chr8:58192753 C8orf71 -0.59 -12.3 -0.44 2.45e-31 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.522 rs12341844 chr9:5177872 C/T cg02405213 chr9:5042618 JAK2 -0.48 -9.15 -0.34 7.86e-19 Pediatric autoimmune diseases; BRCA cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg13319975 chr6:146136371 FBXO30 0.41 8.99 0.34 2.67e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg21433313 chr16:3507492 NAT15 -0.6 -8.35 -0.31 4.14e-16 Tuberculosis; BRCA cis rs4363385 0.720 rs6680624 chr1:152983872 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.89 -0.36 1.52e-21 Inflammatory skin disease; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg08470875 chr2:26401718 FAM59B 0.72 11.93 0.43 8.78e-30 Gut microbiome composition (summer); BRCA cis rs9287719 0.967 rs12692417 chr2:10745718 C/G cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs9467773 0.620 rs2494696 chr6:26620894 A/G cg09904177 chr6:26538194 HMGN4 0.47 14.69 0.5 2.58e-42 Intelligence (multi-trait analysis); BRCA cis rs7607369 0.580 rs7568196 chr2:219652373 G/A cg02176678 chr2:219576539 TTLL4 -0.47 -12.22 -0.44 5.27e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg24977027 chr2:88469347 THNSL2 0.46 7.99 0.3 6.1e-15 Plasma clusterin levels; BRCA cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg00745463 chr17:30367425 LRRC37B -0.57 -9.35 -0.35 1.42e-19 Hip circumference adjusted for BMI; BRCA cis rs858239 0.632 rs6952947 chr7:23121042 C/G cg23682824 chr7:23144976 KLHL7 -0.44 -11.65 -0.42 1.44e-28 Cerebrospinal fluid biomarker levels; BRCA cis rs875971 0.862 rs778686 chr7:65835910 C/T cg11764359 chr7:65958608 NA 0.77 17.59 0.57 9.21e-57 Aortic root size; BRCA cis rs9308433 0.529 rs59864830 chr1:214474889 A/G cg06198575 chr1:214491504 SMYD2 0.58 11.77 0.42 4.48e-29 IgG glycosylation; BRCA cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg19077165 chr18:44547161 KATNAL2 -0.59 -13.29 -0.47 9.5e-36 Personality dimensions; BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg04267008 chr7:1944627 MAD1L1 -0.48 -10.85 -0.39 2.65e-25 Bipolar disorder and schizophrenia; BRCA trans rs4650994 1.000 rs4077194 chr1:178533832 A/C cg05059571 chr16:84539110 KIAA1609 0.36 8.31 0.31 5.97e-16 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg08564027 chr20:61660810 NA 0.84 22.49 0.66 5.99e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.61 -0.32 5.88e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs11997175 0.784 rs36083407 chr8:33812930 G/T ch.8.33884649F chr8:33765107 NA 0.43 10.39 0.38 1.74e-23 Body mass index; BRCA cis rs9929218 0.551 rs3785133 chr16:68728611 C/T cg01251360 chr16:68772225 CDH1 -0.2 -7.95 -0.3 8.57e-15 Colorectal cancer; BRCA cis rs1801251 1.000 rs7592717 chr2:233577038 G/A cg08000102 chr2:233561755 GIGYF2 0.64 13.84 0.48 2.76e-38 Coronary artery disease; BRCA cis rs10789491 1.000 rs10749863 chr1:47174328 C/T cg15501359 chr1:47185051 KIAA0494 0.66 18.1 0.58 1.96e-59 Response to hepatitis C treatment; BRCA cis rs698813 0.774 rs2304769 chr2:44569474 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.59 11.47 0.41 7.78e-28 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg11062466 chr8:58055876 NA 0.42 8.0 0.3 6.04e-15 Developmental language disorder (linguistic errors); BRCA cis rs10197940 0.578 rs2432957 chr2:152287897 A/C cg19508488 chr2:152266495 RIF1 0.39 8.4 0.32 2.83e-16 Lung cancer; BRCA trans rs561341 1.000 rs550264 chr17:30317540 G/T cg20587970 chr11:113659929 NA -1.24 -22.64 -0.67 8.57e-84 Hip circumference adjusted for BMI; BRCA cis rs738321 0.757 rs2284062 chr22:38544221 A/G cg25457927 chr22:38595422 NA -0.36 -12.81 -0.45 1.31e-33 Breast cancer; BRCA cis rs870825 0.616 rs28442259 chr4:185646962 T/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2010099 0.941 rs73191621 chr3:124303090 T/C cg14688451 chr3:124303035 KALRN 0.55 9.08 0.34 1.38e-18 Thyroid peroxidase antibody levels; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg25703541 chr22:24373054 LOC391322 -0.66 -15.05 -0.51 4.73e-44 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05901451 chr6:126070800 HEY2 -0.71 -20.6 -0.63 1.08e-72 Brugada syndrome; BRCA cis rs4595586 0.525 rs11612680 chr12:39344443 A/G cg26384229 chr12:38710491 ALG10B 0.54 11.37 0.41 2.1e-27 Morning vs. evening chronotype; BRCA cis rs1401999 1.000 rs6443924 chr3:183679532 A/G cg01324343 chr3:183735012 ABCC5 0.83 20.85 0.64 4.81e-74 Anterior chamber depth; BRCA cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg01475377 chr6:109611718 NA -0.59 -16.37 -0.54 1.4e-50 Reticulocyte fraction of red cells; BRCA cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg03351412 chr1:154909251 PMVK 0.59 13.6 0.47 3.55e-37 Prostate cancer; BRCA cis rs11098499 0.863 rs7699064 chr4:120428309 A/G cg09307838 chr4:120376055 NA -0.68 -13.66 -0.48 1.94e-37 Corneal astigmatism; BRCA cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg20108693 chr8:143823809 SLURP1 0.41 11.68 0.42 1.07e-28 Urinary tract infection frequency; BRCA cis rs4481887 0.861 rs4295906 chr1:248429861 C/T cg00666640 chr1:248458726 OR2T12 0.32 8.67 0.32 3.56e-17 Common traits (Other); BRCA cis rs68170813 0.559 rs77013162 chr7:107071674 A/C cg02696742 chr7:106810147 HBP1 -0.53 -8.24 -0.31 9.54e-16 Coronary artery disease; BRCA cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg12564285 chr5:131593104 PDLIM4 0.35 9.4 0.35 9.49e-20 Blood metabolite levels; BRCA cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg04455712 chr21:45112962 RRP1B 0.4 10.68 0.39 1.29e-24 Mean corpuscular volume; BRCA cis rs651907 1.000 rs662792 chr3:101599608 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.34 8.88 0.33 6.56e-18 Colorectal cancer; BRCA cis rs2204008 0.618 rs8186932 chr12:38338386 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.82 -0.36 2.72e-21 Bladder cancer; BRCA cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg10556349 chr10:835070 NA 0.75 9.92 0.37 1.09e-21 Eosinophil percentage of granulocytes; BRCA cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg21132104 chr15:45694354 SPATA5L1 0.73 16.29 0.54 3.75e-50 Homoarginine levels; BRCA cis rs11722228 1.000 rs4697695 chr4:9915850 C/T cg00071950 chr4:10020882 SLC2A9 0.39 8.35 0.31 4.26e-16 Gout;Urate levels;Serum uric acid levels; BRCA trans rs11088226 0.681 rs2833895 chr21:33929802 G/A cg09050820 chr6:167586206 TCP10L2 0.76 13.66 0.48 1.9e-37 Gastritis; BRCA trans rs2204008 0.837 rs1842599 chr12:37986081 G/A cg06521331 chr12:34319734 NA 0.43 8.47 0.32 1.7e-16 Bladder cancer; BRCA cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg15448220 chr1:150897856 SETDB1 0.35 7.99 0.3 6.16e-15 Melanoma; BRCA cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg23018236 chr17:30244563 NA -0.64 -10.28 -0.38 4.62e-23 Hip circumference adjusted for BMI; BRCA cis rs4595586 0.679 rs11169992 chr12:39317207 C/T cg26384229 chr12:38710491 ALG10B 0.36 7.85 0.3 1.75e-14 Morning vs. evening chronotype; BRCA cis rs9457247 0.579 rs2181059 chr6:167441624 T/C cg07741184 chr6:167504864 NA 0.27 8.1 0.31 2.78e-15 Crohn's disease; BRCA cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg11833968 chr6:79620685 NA 0.41 9.43 0.35 7.26e-20 Intelligence (multi-trait analysis); BRCA cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg11301795 chr4:187892539 NA -0.3 -10.15 -0.37 1.55e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.01 -0.3 5.37e-15 Total body bone mineral density; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg02353165 chr6:42928485 GNMT 0.76 18.64 0.59 2.94e-62 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4243830 1.000 rs12027598 chr1:6600804 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.92 12.84 0.45 9.64e-34 Body mass index; BRCA cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg02659138 chr7:134003124 SLC35B4 0.35 9.96 0.37 8.04e-22 Mean platelet volume; BRCA cis rs754466 0.580 rs11002301 chr10:79574078 G/A cg17075019 chr10:79541650 NA -0.86 -23.5 -0.68 1.74e-88 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg04025307 chr7:1156635 C7orf50 0.52 10.06 0.37 3.2800000000000002e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2835872 0.758 rs1709835 chr21:39037636 A/G cg06728970 chr21:39037746 KCNJ6 0.45 12.93 0.46 3.9e-34 Electroencephalographic traits in alcoholism; BRCA cis rs30380 0.587 rs30185 chr5:96125465 G/A cg16492584 chr5:96139282 ERAP1 -0.46 -10.84 -0.39 3.03e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg18230493 chr5:56204884 C5orf35 -0.68 -13.41 -0.47 2.57e-36 Initial pursuit acceleration; BRCA cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 8.96 0.33 3.55e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs921968 0.541 rs485975 chr2:219374250 C/T cg10223061 chr2:219282414 VIL1 -0.27 -7.95 -0.3 8.39e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs2882667 0.589 rs825770 chr5:138115219 T/G cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg01939980 chr4:1354348 KIAA1530 0.4 9.86 0.36 2e-21 Obesity-related traits; BRCA cis rs11676348 0.791 rs6726126 chr2:218952233 G/A cg00012203 chr2:219082015 ARPC2 -0.4 -7.85 -0.3 1.82e-14 Ulcerative colitis; BRCA cis rs6087990 0.899 rs6087999 chr20:31363774 A/G cg13636640 chr20:31349939 DNMT3B 0.76 25.07 0.7 4.15e-97 Ulcerative colitis; BRCA cis rs3849570 1.000 rs11915016 chr3:81833966 G/A cg07356753 chr3:81810745 GBE1 -0.47 -11.33 -0.41 3.13e-27 Waist circumference;Body mass index; BRCA cis rs6582630 0.519 rs4405392 chr12:38293661 A/C cg13010199 chr12:38710504 ALG10B 0.5 10.53 0.38 4.99e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs4363385 0.747 rs6587716 chr1:152966705 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.39 -0.35 1.01e-19 Inflammatory skin disease; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg23708337 chr7:1209742 NA 0.61 8.87 0.33 7.38e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs34779708 0.801 rs12255409 chr10:35535425 G/A cg03585969 chr10:35415529 CREM 0.46 9.27 0.34 2.77e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs8018808 0.935 rs8018513 chr14:77928288 T/C cg20045696 chr14:77926864 AHSA1 0.37 8.47 0.32 1.72e-16 Myeloid white cell count; BRCA cis rs2625529 0.652 rs3759820 chr15:72300031 A/C cg16672083 chr15:72433130 SENP8 0.68 16.39 0.54 1.14e-50 Red blood cell count; BRCA cis rs7520050 0.966 rs11579634 chr1:46466391 A/G cg24296786 chr1:45957014 TESK2 -0.42 -9.42 -0.35 8.1e-20 Red blood cell count;Reticulocyte count; BRCA trans rs61931739 0.534 rs1211286 chr12:34135581 T/C cg13010199 chr12:38710504 ALG10B 0.39 8.1 0.31 2.69e-15 Morning vs. evening chronotype; BRCA cis rs9527 0.590 rs10883830 chr10:104851285 G/A cg04362960 chr10:104952993 NT5C2 0.45 10.26 0.38 5.92e-23 Arsenic metabolism; BRCA cis rs9467773 0.967 rs7753565 chr6:26560012 A/G cg09904177 chr6:26538194 HMGN4 0.55 17.59 0.57 9.06e-57 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg03923535 chr7:1197113 ZFAND2A 0.5 10.95 0.4 1.1e-25 Longevity;Endometriosis; BRCA cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.84 12.53 0.44 2.21e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg17971929 chr21:40555470 PSMG1 -0.47 -10.36 -0.38 2.31e-23 Menarche (age at onset); BRCA cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.59e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg01206211 chr2:36825736 FEZ2 0.49 12.3 0.44 2.33e-31 Height; BRCA cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.67 0.55 4.49e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs6450176 1.000 rs9687611 chr5:53300288 C/T ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2066819 1.000 rs41363748 chr12:56696056 C/T cg26734620 chr12:56694298 CS -0.75 -9.3 -0.35 2.25e-19 Psoriasis vulgaris; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg10729496 chr3:10149963 C3orf24 0.49 9.01 0.34 2.35e-18 Alzheimer's disease; BRCA cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg11941060 chr3:133502564 NA 0.47 11.43 0.41 1.16e-27 Iron status biomarkers; BRCA cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg12386194 chr3:101231763 SENP7 0.67 13.23 0.46 1.71e-35 Colonoscopy-negative controls vs population controls; BRCA cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.48 -0.32 1.59e-16 Monocyte percentage of white cells; BRCA cis rs9815354 0.680 rs114478966 chr3:42007050 T/C cg03022575 chr3:42003672 ULK4 0.65 9.49 0.35 4.62e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg03354898 chr7:1950403 MAD1L1 -0.39 -8.18 -0.31 1.57e-15 Bipolar disorder and schizophrenia; BRCA cis rs7246657 0.943 rs9304566 chr19:37845504 T/C cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA cis rs4713118 0.911 rs9295746 chr6:27730064 T/C cg20933634 chr6:27740509 NA 0.43 8.21 0.31 1.22e-15 Parkinson's disease; BRCA cis rs6500602 0.826 rs11076830 chr16:4460049 A/G cg08645402 chr16:4508243 NA 0.37 8.03 0.3 4.78e-15 Schizophrenia; BRCA cis rs6089829 1.000 rs62207535 chr20:61669187 A/G cg03213289 chr20:61660250 NA 0.63 16.01 0.53 9.62e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs2762353 0.935 rs2817188 chr6:25807603 A/G cg03517284 chr6:25882590 NA -0.46 -10.45 -0.38 1.07e-23 Blood metabolite levels; BRCA cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg22117172 chr7:91764530 CYP51A1 -0.26 -8.78 -0.33 1.54e-17 Breast cancer; BRCA cis rs2073300 0.609 rs3736755 chr20:23377642 C/T cg12062639 chr20:23401060 NAPB 0.91 12.79 0.45 1.65e-33 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg05535760 chr7:792225 HEATR2 0.71 12.93 0.46 3.86e-34 Cerebrospinal P-tau181p levels; BRCA cis rs3857067 0.806 rs6858342 chr4:95112318 G/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs2562152 0.744 rs1045001 chr16:107275 G/T cg02949481 chr16:131562 MPG -0.54 -9.16 -0.34 7.02e-19 Glioblastoma; BRCA cis rs919433 0.713 rs1455653 chr2:198478320 G/A cg00792783 chr2:198669748 PLCL1 0.35 8.13 0.31 2.16e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1348850 0.526 rs4144278 chr2:178412378 C/T cg27490568 chr2:178487706 NA 0.52 8.92 0.33 4.76e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg25809561 chr17:30822961 MYO1D 0.59 15.93 0.53 2.21e-48 Schizophrenia; BRCA cis rs9296092 0.538 rs75652975 chr6:33516251 C/T cg13560919 chr6:33536144 NA -0.85 -17.45 -0.57 4.51e-56 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg26384229 chr12:38710491 ALG10B -0.51 -13.38 -0.47 3.56e-36 Morning vs. evening chronotype; BRCA cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg17971929 chr21:40555470 PSMG1 -0.48 -10.82 -0.39 3.7e-25 Menarche (age at onset); BRCA cis rs3733585 0.699 rs6839490 chr4:9965000 C/G cg00071950 chr4:10020882 SLC2A9 0.37 8.36 0.31 3.84e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1198430 0.929 rs1210852 chr1:23753533 T/C cg19827787 chr1:23763612 ASAP3 0.37 9.85 0.36 2.14e-21 Total cholesterol levels; BRCA cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg02574844 chr11:5959923 NA -0.42 -8.26 -0.31 8.54e-16 DNA methylation (variation); BRCA cis rs950776 0.518 rs952215 chr15:78819153 C/T cg06917634 chr15:78832804 PSMA4 -0.78 -17.95 -0.58 1.18e-58 Sudden cardiac arrest; BRCA cis rs72781680 0.898 rs12614616 chr2:23996501 T/G cg08917208 chr2:24149416 ATAD2B 0.9 12.95 0.46 3.2e-34 Lymphocyte counts; BRCA cis rs2304069 0.909 rs2544931 chr5:149367837 C/G cg10852222 chr5:149380144 HMGXB3;TIGD6 -0.59 -8.69 -0.32 3.13e-17 HIV-1 control; BRCA cis rs9399137 0.507 rs7768278 chr6:135274957 T/C cg22676075 chr6:135203613 NA 0.4 8.15 0.31 1.97e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs875971 0.545 rs313830 chr7:65551931 T/C cg11764359 chr7:65958608 NA -0.64 -11.24 -0.41 7.01e-27 Aortic root size; BRCA cis rs7903847 0.667 rs3818787 chr10:99145179 T/C cg20016023 chr10:99160130 RRP12 -0.25 -8.1 -0.3 2.89e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg08219700 chr8:58056026 NA 0.46 8.42 0.32 2.4e-16 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.6 0.36 1.72e-20 Menopause (age at onset); BRCA cis rs597539 0.652 rs654071 chr11:68653432 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.19 0.58 7e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg05623727 chr3:50126028 RBM5 -0.43 -10.52 -0.38 5.82e-24 Intelligence (multi-trait analysis); BRCA cis rs7523273 0.606 rs1474742 chr1:207976666 A/C cg22525895 chr1:207977042 MIR29B2 0.46 11.97 0.43 6.04e-30 Schizophrenia; BRCA cis rs9859260 0.710 rs419068 chr3:195782176 C/T cg03462622 chr3:195777018 TFRC -0.38 -8.61 -0.32 5.5e-17 Mean corpuscular volume; BRCA cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg04450456 chr4:17643702 FAM184B 0.41 12.15 0.43 1.06e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg04450456 chr4:17643702 FAM184B 0.33 9.45 0.35 6.04e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9649465 1.000 rs2299982 chr7:123356511 A/C cg04330084 chr7:123175371 IQUB -0.33 -9.01 -0.34 2.32e-18 Migraine; BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg00814883 chr7:100076585 TSC22D4 -0.52 -11.77 -0.42 4.38e-29 Platelet count; BRCA trans rs7615952 1.000 rs7615952 chr3:125649403 A/C cg07211511 chr3:129823064 LOC729375 1.05 21.59 0.65 4.62e-78 Blood pressure (smoking interaction); BRCA trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg13010199 chr12:38710504 ALG10B -0.47 -9.11 -0.34 1.01e-18 Morning vs. evening chronotype; BRCA cis rs9287719 0.967 rs4555318 chr2:10744295 C/G cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg16339924 chr4:17578868 LAP3 -0.58 -13.98 -0.48 5.94e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs858239 0.539 rs4559148 chr7:23185967 G/A cg23682824 chr7:23144976 KLHL7 0.37 9.62 0.36 1.54e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs4808199 0.948 rs1859287 chr19:19422187 T/C cg01262667 chr19:19385393 TM6SF2 0.38 8.23 0.31 1.09e-15 Nonalcoholic fatty liver disease; BRCA cis rs11055008 0.620 rs10845608 chr12:12836088 C/T cg09462578 chr12:12878428 APOLD1 0.43 9.68 0.36 9.28e-21 Pulse pressure; BRCA trans rs208520 0.754 rs851593 chr6:66875783 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 19.63 0.61 1.64e-67 Exhaled nitric oxide output; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg13397359 chr6:42928475 GNMT 0.66 16.05 0.54 6.04e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg05457628 chr5:178986728 RUFY1 0.4 9.52 0.35 3.59e-20 Lung cancer; BRCA cis rs9486719 1.000 rs2145535 chr6:97034715 G/A cg06623918 chr6:96969491 KIAA0776 -0.76 -13.44 -0.47 1.88e-36 Migraine;Coronary artery disease; BRCA cis rs6009527 0.752 rs7286232 chr22:49568490 A/G cg12746016 chr22:49560550 NA 0.39 9.13 0.34 9.05e-19 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); BRCA cis rs887829 0.570 rs6736508 chr2:234595747 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.22 -0.31 1.15e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg15704280 chr7:45808275 SEPT13 0.62 10.25 0.38 6.54e-23 Axial length; BRCA cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg26695010 chr11:65641043 EFEMP2 0.38 8.41 0.32 2.62e-16 Eosinophil percentage of white cells; BRCA cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.83 0.39 3.22e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.754 rs12509621 chr4:120249660 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.38e-23 Corneal astigmatism; BRCA cis rs6459788 0.605 rs887628 chr7:157237589 G/A cg06271696 chr7:157225062 NA -0.37 -9.71 -0.36 7.04e-21 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs2742234 0.578 rs2435354 chr10:43652445 C/T cg02780029 chr10:43622663 RET -0.35 -7.81 -0.3 2.4e-14 Hirschsprung disease; BRCA cis rs4631830 0.737 rs7071471 chr10:51503335 C/T cg20129853 chr10:51489980 NA 0.29 7.91 0.3 1.12e-14 Prostate-specific antigen levels; BRCA cis rs9527 0.568 rs1926036 chr10:104883812 C/T cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg03929089 chr4:120376271 NA -0.98 -29.5 -0.76 2.38e-121 Height; BRCA trans rs9944715 1.000 rs9959813 chr18:43841082 C/T cg01718231 chr17:29326311 RNF135 0.45 8.99 0.34 2.82e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs17376456 0.741 rs7718842 chr5:93480568 G/A cg25358565 chr5:93447407 FAM172A 1.25 18.29 0.59 2.09e-60 Diabetic retinopathy; BRCA cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs965469 1.000 rs2236117 chr20:3302021 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.14 -0.37 1.68e-22 IFN-related cytopenia; BRCA cis rs11971779 0.680 rs4732370 chr7:139077240 A/C cg07862535 chr7:139043722 LUC7L2 -0.39 -10.66 -0.39 1.52e-24 Diisocyanate-induced asthma; BRCA trans rs1997103 0.906 rs2177806 chr7:55402609 A/T cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg21951975 chr1:209979733 IRF6 0.39 8.39 0.31 3.18e-16 Cleft lip with or without cleft palate; BRCA cis rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05901451 chr6:126070800 HEY2 0.39 9.55 0.35 2.8e-20 Endometrial cancer; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.35 -0.41 2.51e-27 Gut microbiome composition (summer); BRCA cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.4 0.41 1.56e-27 Height; BRCA cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.61 -13.84 -0.48 2.86e-38 Platelet count; BRCA cis rs2637030 0.559 rs256083 chr5:52893681 G/A cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.08 0.4 3.31e-26 Bipolar disorder; BRCA trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg22491629 chr6:157744540 C6orf35 -0.65 -11.65 -0.42 1.47e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg03213289 chr20:61660250 NA 0.61 16.07 0.54 4.85e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg04944784 chr2:26401820 FAM59B -0.66 -11.2 -0.41 1.06e-26 Gut microbiome composition (summer); BRCA cis rs7246657 0.722 rs2909102 chr19:38167364 C/T cg18154014 chr19:37997991 ZNF793 -0.51 -9.56 -0.35 2.58e-20 Coronary artery calcification; BRCA cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg19077165 chr18:44547161 KATNAL2 -0.64 -14.56 -0.5 1.14e-41 Personality dimensions; BRCA cis rs910316 1.000 rs175436 chr14:75608683 C/G cg08847533 chr14:75593920 NEK9 -0.83 -20.94 -0.64 1.66e-74 Height; BRCA cis rs11098499 1.000 rs11726229 chr4:120211580 C/T cg09307838 chr4:120376055 NA 0.65 13.17 0.46 3.31e-35 Corneal astigmatism; BRCA cis rs2422052 0.654 rs1433530 chr2:118649083 G/A cg22545206 chr2:118617499 NA 0.4 9.84 0.36 2.24e-21 Mosquito bite size; BRCA cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg06212747 chr3:49208901 KLHDC8B 0.45 9.37 0.35 1.26e-19 Parkinson's disease; BRCA trans rs3733585 0.699 rs6449158 chr4:9960459 T/C cg26043149 chr18:55253948 FECH -0.37 -8.21 -0.31 1.2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4363385 0.818 rs4845514 chr1:153000820 T/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.74 -0.33 2.11e-17 Inflammatory skin disease; BRCA cis rs3008870 0.755 rs1925409 chr1:67365089 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.62 -13.15 -0.46 3.85e-35 Lymphocyte percentage of white cells; BRCA cis rs870825 0.655 rs72703561 chr4:185630890 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.9e-54 Blood protein levels; BRCA cis rs698833 0.886 rs2053454 chr2:44550290 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.0 0.37 5.74e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg12310025 chr6:25882481 NA -0.5 -11.01 -0.4 6.42e-26 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.43 0.57 6.11e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs826838 0.616 rs2200605 chr12:38624088 G/A cg26384229 chr12:38710491 ALG10B 0.43 10.26 0.38 5.72e-23 Heart rate; BRCA cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg26677194 chr12:130822605 PIWIL1 0.6 14.33 0.49 1.31e-40 Menopause (age at onset); BRCA cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7647973 1.000 rs3866330 chr3:49582994 T/C cg07636037 chr3:49044803 WDR6 0.73 15.92 0.53 2.73e-48 Menarche (age at onset); BRCA trans rs11098499 0.645 rs72676059 chr4:120290828 C/G cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg08999081 chr20:33150536 PIGU 0.36 9.03 0.34 2.01e-18 Coronary artery disease; BRCA trans rs35110281 0.805 rs4818855 chr21:45038951 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.37 8.13 0.31 2.16e-15 Mean corpuscular volume; BRCA cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg10802521 chr3:52805072 NEK4 -0.33 -8.37 -0.31 3.7e-16 Bipolar disorder; BRCA cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg03425785 chr20:62221387 GMEB2 0.51 8.26 0.31 8.42e-16 Glioblastoma; BRCA cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg19784903 chr17:45786737 TBKBP1 -0.45 -10.72 -0.39 9.07e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7635838 0.596 rs443503 chr3:11261912 A/T cg00170343 chr3:11313890 ATG7 -0.39 -8.08 -0.3 3.13e-15 HDL cholesterol; BRCA cis rs6459788 0.693 rs35146559 chr7:157238557 G/A cg03453431 chr7:157225567 NA -0.45 -8.97 -0.33 3.2e-18 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg14019146 chr3:50243930 SLC38A3 -0.45 -10.92 -0.4 1.4e-25 Intelligence (multi-trait analysis); BRCA trans rs931812 0.964 rs2102290 chr8:101919844 G/C cg20993868 chr7:22813445 NA 0.49 13.56 0.47 5.25e-37 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs10751667 0.600 rs7394783 chr11:1005108 C/T ch.11.42038R chr11:967971 AP2A2 -0.47 -14.47 -0.5 2.87e-41 Alzheimer's disease (late onset); BRCA cis rs2710642 0.888 rs13418889 chr2:63079775 T/C cg17519650 chr2:63277830 OTX1 0.38 8.43 0.32 2.36e-16 LDL cholesterol levels;LDL cholesterol; BRCA cis rs9790314 0.582 rs6796201 chr3:160634313 A/G cg03342759 chr3:160939853 NMD3 0.43 8.63 0.32 4.82e-17 Morning vs. evening chronotype; BRCA cis rs2882667 0.754 rs11746434 chr5:138435303 A/G cg04439458 chr5:138467593 SIL1 -0.43 -10.74 -0.39 7.24e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs193541 0.632 rs154512 chr5:122195040 T/C cg19412675 chr5:122181750 SNX24 0.32 7.85 0.3 1.79e-14 Glucose homeostasis traits; BRCA cis rs1448094 0.512 rs6539932 chr12:86247497 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.39 -0.35 1.02e-19 Major depressive disorder; BRCA cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.79e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg06917634 chr15:78832804 PSMA4 -0.78 -17.48 -0.57 3.41e-56 Sudden cardiac arrest; BRCA cis rs2742234 0.541 rs11238481 chr10:43719286 A/G cg02780029 chr10:43622663 RET 0.35 7.86 0.3 1.69e-14 Hirschsprung disease; BRCA cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg07606381 chr6:8435919 SLC35B3 0.64 14.22 0.49 4.42e-40 Motion sickness; BRCA cis rs2980436 1 rs2980436 chr8:8092025 A/G cg11608241 chr8:8085544 FLJ10661 -0.35 -9.73 -0.36 5.76e-21 Schizophrenia; BRCA trans rs629535 0.814 rs674429 chr8:70069942 G/A cg21567404 chr3:27674614 NA 1.01 20.96 0.64 1.2e-74 Dupuytren's disease; BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg01262667 chr19:19385393 TM6SF2 0.41 10.52 0.38 5.77e-24 Tonsillectomy; BRCA cis rs72627509 0.638 rs7658601 chr4:57781347 C/T cg26694713 chr4:57773883 REST 0.46 8.55 0.32 8.93e-17 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs12618769 0.652 rs1139829 chr2:99225168 C/T cg10123293 chr2:99228465 UNC50 0.44 8.64 0.32 4.34e-17 Bipolar disorder; BRCA cis rs4800452 0.745 rs8093542 chr18:20709123 A/C cg26136497 chr18:20735537 CABLES1 -0.4 -9.08 -0.34 1.33e-18 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs2898290 0.592 rs2736342 chr8:11347289 A/C cg21775007 chr8:11205619 TDH -0.37 -7.86 -0.3 1.6e-14 Systolic blood pressure; BRCA cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg17724175 chr1:150552817 MCL1 0.25 8.17 0.31 1.6e-15 Tonsillectomy; BRCA cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg16850897 chr7:100343110 ZAN 0.35 8.08 0.3 3.16e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg21926612 chr6:163149169 PACRG;PARK2 1.0 15.21 0.52 8.07e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14240646 chr10:27532245 ACBD5 -0.62 -9.58 -0.35 2.13e-20 Breast cancer; BRCA cis rs10504073 0.669 rs62507251 chr8:50028524 T/G cg00325661 chr8:49890786 NA 0.44 12.16 0.43 9.27e-31 Blood metabolite ratios; BRCA cis rs6840360 0.571 rs7695866 chr4:152488110 G/A cg22705602 chr4:152727874 NA -0.31 -8.05 -0.3 4.03e-15 Intelligence (multi-trait analysis); BRCA cis rs10504073 0.584 rs62507178 chr8:49938572 A/C cg00325661 chr8:49890786 NA 0.52 14.71 0.5 2.04e-42 Blood metabolite ratios; BRCA cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.5 -0.38 6.64e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg07537917 chr2:241836409 C2orf54 -0.49 -11.74 -0.42 5.86e-29 Urinary metabolites; BRCA cis rs3824867 0.920 rs9734013 chr11:47451517 G/T cg20307385 chr11:47447363 PSMC3 -0.49 -10.94 -0.4 1.16e-25 Mean corpuscular hemoglobin; BRCA cis rs507080 0.922 rs638805 chr11:118558889 G/T cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs7818345 0.967 rs6992893 chr8:19287504 G/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.97 0.3 7.11e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs559928 1.000 rs641168 chr11:64146289 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.54 -8.08 -0.3 3.17e-15 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg25173405 chr17:45401733 C17orf57 0.47 9.82 0.36 2.7e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7927771 0.524 rs3816605 chr11:47857253 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.62 0.36 1.56e-20 Subjective well-being; BRCA cis rs597539 0.652 rs613128 chr11:68638058 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 16.51 0.55 2.77e-51 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg09021430 chr5:549028 NA -0.69 -14.43 -0.5 4.56e-41 Lung disease severity in cystic fibrosis; BRCA cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg02187348 chr16:89574699 SPG7 0.51 12.23 0.44 4.91e-31 Multiple myeloma (IgH translocation); BRCA cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg07952391 chr2:88470173 THNSL2 -0.4 -8.01 -0.3 5.51e-15 Response to metformin (IC50); BRCA cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg18478394 chr8:109455254 TTC35 0.29 8.56 0.32 8.59e-17 Dupuytren's disease; BRCA cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.84 -0.53 6.63e-48 Systemic lupus erythematosus; BRCA cis rs11249608 0.789 rs7704963 chr5:178436854 A/G cg21905437 chr5:178450457 ZNF879 0.44 9.0 0.34 2.46e-18 Pubertal anthropometrics; BRCA cis rs9914988 0.943 rs11658884 chr17:27132742 A/G cg20469991 chr17:27169893 C17orf63 0.45 8.82 0.33 1.12e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7829975 0.606 rs6422352 chr8:8794193 A/G cg08975724 chr8:8085496 FLJ10661 -0.41 -8.72 -0.33 2.47e-17 Mood instability; BRCA cis rs6547741 1.000 rs6547734 chr2:27830990 G/T cg27432699 chr2:27873401 GPN1 0.46 9.69 0.36 8.42e-21 Oral cavity cancer; BRCA cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.49 0.5 2.52e-41 Motion sickness; BRCA cis rs6964587 1.000 rs1063243 chr7:91726927 A/C cg17063962 chr7:91808500 NA 0.53 12.49 0.44 3.57e-32 Breast cancer; BRCA trans rs11098499 0.754 rs11724409 chr4:120252361 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA trans rs2204008 0.744 rs66474616 chr12:38461564 G/A cg06521331 chr12:34319734 NA -0.49 -8.94 -0.33 4.09e-18 Bladder cancer; BRCA cis rs12541635 0.966 rs7819327 chr8:106986003 A/C cg10147462 chr8:107024639 NA 0.39 10.31 0.38 3.69e-23 Age of smoking initiation; BRCA trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg15704280 chr7:45808275 SEPT13 -0.55 -10.6 -0.39 2.7e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg13770153 chr20:60521292 NA -0.54 -11.45 -0.41 9.39e-28 Body mass index; BRCA cis rs67460515 0.563 rs35914913 chr3:160826561 A/G cg03342759 chr3:160939853 NMD3 -0.71 -14.27 -0.49 2.56e-40 Parkinson's disease; BRCA cis rs11190604 1.000 rs4244338 chr10:102272802 A/G cg07080220 chr10:102295463 HIF1AN 0.61 14.45 0.5 3.82e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9287719 0.601 rs1861300 chr2:10763961 A/G cg00105475 chr2:10696890 NA 0.47 10.32 0.38 3.26e-23 Prostate cancer; BRCA cis rs6964587 1.000 rs2299240 chr7:91654618 A/G cg17063962 chr7:91808500 NA 0.57 13.51 0.47 8.97e-37 Breast cancer; BRCA cis rs9389248 0.690 rs1028314 chr6:135255710 A/C cg22676075 chr6:135203613 NA -0.46 -9.64 -0.36 1.25e-20 High light scatter reticulocyte percentage of red cells; BRCA trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg20587970 chr11:113659929 NA -1.34 -24.21 -0.69 2.24e-92 Hip circumference adjusted for BMI; BRCA trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA cis rs9811920 0.683 rs4928230 chr3:99661963 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -11.18 -0.4 1.29e-26 Axial length; BRCA trans rs4650994 0.967 rs4650992 chr1:178515135 A/T cg05059571 chr16:84539110 KIAA1609 -0.42 -9.6 -0.36 1.71e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.43 -0.44 6.2e-32 Chronic sinus infection; BRCA cis rs7043114 0.525 rs1053446 chr9:95146761 T/A cg14631576 chr9:95140430 CENPP -0.33 -8.33 -0.31 4.77e-16 Height; BRCA cis rs2016266 0.859 rs10876433 chr12:53734114 G/A cg26875137 chr12:53738046 NA -0.44 -9.74 -0.36 5.43e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg05340658 chr4:99064831 C4orf37 0.7 17.39 0.57 9.76e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg05283184 chr6:79620031 NA -0.41 -10.37 -0.38 2.09e-23 Intelligence (multi-trait analysis); BRCA cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.17 -0.37 1.33e-22 Body mass index; BRCA cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg05294307 chr14:35346193 BAZ1A -0.57 -9.99 -0.37 5.97e-22 Psoriasis; BRCA cis rs11711311 0.747 rs7638378 chr3:113343630 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.07 0.3 3.41e-15 IgG glycosylation; BRCA cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4594175 0.926 rs9323206 chr14:51621800 C/T cg23942311 chr14:51606299 NA 0.33 8.36 0.31 4.05e-16 Cancer; BRCA cis rs10267417 0.603 rs13307910 chr7:19858392 C/T cg07541023 chr7:19748670 TWISTNB 0.48 8.85 0.33 8.88e-18 Night sleep phenotypes; BRCA cis rs2279817 0.735 rs12067869 chr1:17989765 G/T cg21791023 chr1:18019539 ARHGEF10L -0.45 -11.57 -0.42 2.92e-28 Neuroticism; BRCA cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg11266682 chr4:10021025 SLC2A9 0.49 13.12 0.46 5.22e-35 Bone mineral density; BRCA cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg13010199 chr12:38710504 ALG10B -0.35 -8.54 -0.32 9.47e-17 Morning vs. evening chronotype; BRCA cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg22307029 chr19:49891270 CCDC155 0.54 9.03 0.34 2.04e-18 Multiple sclerosis; BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg08888203 chr3:10149979 C3orf24 0.65 11.91 0.43 1.07e-29 Alzheimer's disease; BRCA cis rs758324 0.812 rs477086 chr5:131284610 C/T cg06307176 chr5:131281290 NA -0.47 -10.21 -0.37 8.96e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg04756594 chr16:24857601 SLC5A11 0.36 8.78 0.33 1.43e-17 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs1129655 chr1:152958267 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.12 -0.31 2.37e-15 Inflammatory skin disease; BRCA cis rs2274471 0.699 rs10974985 chr9:5156061 C/T cg03390472 chr9:5043263 JAK2 0.44 8.08 0.3 3.25e-15 Crohn's disease; BRCA cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg18479299 chr3:125709523 NA -0.53 -8.18 -0.31 1.53e-15 Blood pressure (smoking interaction); BRCA cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg00745463 chr17:30367425 LRRC37B -0.61 -9.51 -0.35 3.69e-20 Hip circumference adjusted for BMI; BRCA cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg00684032 chr4:1343700 KIAA1530 0.52 12.28 0.44 2.85e-31 Obesity-related traits; BRCA cis rs2304069 0.954 rs1433010 chr5:149383954 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.84 -17.06 -0.56 4.66e-54 HIV-1 control; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg14004847 chr7:1930337 MAD1L1 0.43 8.86 0.33 8.06e-18 Bipolar disorder and schizophrenia; BRCA cis rs9649213 0.593 rs34776142 chr7:97899873 C/T cg24562669 chr7:97807699 LMTK2 0.46 11.8 0.42 3.21e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.541 rs12617603 chr2:219369288 A/G cg10223061 chr2:219282414 VIL1 0.3 8.47 0.32 1.72e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs17376456 0.877 rs12153501 chr5:93360866 T/G cg21475434 chr5:93447410 FAM172A 0.67 8.97 0.33 3.29e-18 Diabetic retinopathy; BRCA cis rs7666738 0.830 rs11725477 chr4:98803266 G/T cg17366294 chr4:99064904 C4orf37 0.41 9.27 0.34 2.92e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg18404041 chr3:52824283 ITIH1 0.43 13.51 0.47 9.39e-37 Bipolar disorder; BRCA cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg26384229 chr12:38710491 ALG10B 0.85 22.95 0.67 1.8e-85 Heart rate; BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg18404041 chr3:52824283 ITIH1 -0.32 -9.54 -0.35 2.84e-20 Cognitive function; BRCA cis rs7617773 0.780 rs3197223 chr3:48335857 C/T cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg11764359 chr7:65958608 NA -0.67 -14.95 -0.51 1.53e-43 Aortic root size; BRCA cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.88 -0.3 1.43e-14 Bipolar disorder; BRCA cis rs561341 1.000 rs550264 chr17:30317540 G/T cg23018236 chr17:30244563 NA -0.64 -10.28 -0.38 4.62e-23 Hip circumference adjusted for BMI; BRCA cis rs1707322 0.686 rs3014239 chr1:46089801 G/A cg03146154 chr1:46216737 IPP -0.5 -11.16 -0.4 1.54e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.6e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.19 -0.31 1.45e-15 Colorectal cancer; BRCA cis rs870825 0.616 rs67409049 chr4:185623989 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg23109721 chr2:106886537 NA -0.46 -8.34 -0.31 4.6e-16 Facial morphology (factor 23); BRCA cis rs3845702 0.736 rs6433818 chr2:180810264 A/T cg01881094 chr2:180872142 CWC22 -1.03 -17.25 -0.56 5.06e-55 Schizophrenia; BRCA cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg14844989 chr11:31128820 NA -0.46 -9.91 -0.36 1.27e-21 Red blood cell count; BRCA cis rs6665290 0.901 rs2104860 chr1:227208637 G/C cg10327440 chr1:227177885 CDC42BPA -1.09 -38.38 -0.84 4.95e-168 Myeloid white cell count; BRCA trans rs7618501 0.699 rs2681780 chr3:49897830 C/T cg21659725 chr3:3221576 CRBN 0.52 13.59 0.47 3.75e-37 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs7647973 0.626 rs9830730 chr3:49675875 G/C cg07636037 chr3:49044803 WDR6 0.52 8.46 0.32 1.81e-16 Menarche (age at onset); BRCA cis rs12478296 1.000 rs56292923 chr2:243039986 C/T cg18898632 chr2:242989856 NA -0.5 -8.54 -0.32 9.65e-17 Obesity-related traits; BRCA cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg27535305 chr1:53392650 SCP2 -0.37 -9.32 -0.35 1.85e-19 Monocyte count; BRCA cis rs16866061 0.926 rs17479770 chr2:225335814 A/G cg12698349 chr2:225449008 CUL3 0.74 17.78 0.58 9.15e-58 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs4389656 0.740 rs412643 chr5:6720715 A/G cg10857441 chr5:6722123 POLS -0.25 -7.82 -0.3 2.22e-14 Coronary artery disease; BRCA cis rs2073300 1.000 rs12625999 chr20:23442085 A/G cg12062639 chr20:23401060 NAPB -0.88 -10.65 -0.39 1.65e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2505998 0.843 rs2506004 chr10:43582273 A/C cg15436174 chr10:43711423 RASGEF1A -0.4 -7.97 -0.3 7.42e-15 Hirschsprung disease; BRCA cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg02880119 chr16:3481970 NA 0.44 8.16 0.31 1.77e-15 Body mass index (adult); BRCA cis rs853679 0.517 rs9348796 chr6:28126202 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA cis rs172166 0.694 rs203877 chr6:28048624 T/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.41 0.32 2.74e-16 Cardiac Troponin-T levels; BRCA cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg18225595 chr11:63971243 STIP1 0.4 9.91 0.37 1.2e-21 Platelet count; BRCA cis rs17095355 1.000 rs12570607 chr10:111696704 C/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.05 -0.37 3.83e-22 Biliary atresia; BRCA cis rs4243830 0.850 rs12410405 chr1:6581283 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.8 16.01 0.54 9.17e-49 Body mass index; BRCA cis rs6598955 0.543 rs79778574 chr1:26538482 A/G cg04990556 chr1:26633338 UBXN11 0.7 11.98 0.43 5.53e-30 Obesity-related traits; BRCA cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg07636037 chr3:49044803 WDR6 0.81 20.97 0.64 1.15e-74 Menarche (age at onset); BRCA cis rs7100689 0.622 rs1890890 chr10:82090643 A/T cg00277334 chr10:82204260 NA -0.44 -8.62 -0.32 5.31e-17 Post bronchodilator FEV1; BRCA cis rs1941023 0.503 rs4939348 chr11:60135871 A/C cg08716584 chr11:60157161 MS4A7 -0.42 -9.79 -0.36 3.45e-21 Congenital heart disease (maternal effect); BRCA cis rs74181299 0.684 rs1420184 chr2:65315880 G/C cg05010058 chr2:65284262 CEP68 -0.29 -7.93 -0.3 9.96e-15 Pulse pressure; BRCA cis rs4671400 0.571 rs4672429 chr2:61495469 G/C cg15711740 chr2:61764176 XPO1 0.39 7.96 0.3 7.63e-15 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs10501293 1.000 rs1559762 chr11:43128541 C/T cg03447554 chr11:43094025 NA 0.49 9.0 0.34 2.47e-18 Cognitive performance; BRCA cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg05535760 chr7:792225 HEATR2 0.78 13.66 0.48 1.8e-37 Cerebrospinal P-tau181p levels; BRCA cis rs1971762 0.583 rs3852561 chr12:54085842 C/T cg23533419 chr12:54090519 NA -0.33 -8.39 -0.32 3.12e-16 Height; BRCA cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg18876405 chr7:65276391 NA 0.5 11.04 0.4 4.57e-26 Aortic root size; BRCA cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg13852791 chr20:30311386 BCL2L1 0.85 16.54 0.55 2.16e-51 Mean corpuscular hemoglobin; BRCA cis rs798766 1.000 rs3752749 chr4:1737262 T/C cg05874882 chr4:1763078 NA -0.47 -8.46 -0.32 1.79e-16 Bladder cancer;Urinary bladder cancer; BRCA cis rs2742234 0.590 rs2435383 chr10:43675671 T/C cg15436174 chr10:43711423 RASGEF1A -0.54 -10.87 -0.4 2.23e-25 Hirschsprung disease; BRCA cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg04607235 chr12:12878440 APOLD1 -0.63 -10.14 -0.37 1.65e-22 Systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.94e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 8.91e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs6964530 chr7:65718851 G/C cg18252515 chr7:66147081 NA 1.02 15.22 0.52 7.34e-45 Diabetic kidney disease; BRCA cis rs858239 0.539 rs2390757 chr7:23191492 A/G cg23682824 chr7:23144976 KLHL7 0.36 9.47 0.35 5.44e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs6446731 0.517 rs2858087 chr4:3268892 A/T cg08886695 chr4:3369023 RGS12 0.38 10.09 0.37 2.57e-22 Mean platelet volume; BRCA cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs10751667 0.621 rs7396107 chr11:970029 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.59 0.55 1.19e-51 Alzheimer's disease (late onset); BRCA cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg20503657 chr10:835505 NA 1.05 18.47 0.59 2.42e-61 Eosinophil percentage of granulocytes; BRCA cis rs4974559 0.739 rs10032327 chr4:1323537 C/T cg02980000 chr4:1222292 CTBP1 0.81 12.97 0.46 2.66e-34 Systolic blood pressure; BRCA cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.33 0.61 6.67e-66 Smoking behavior; BRCA cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg10523679 chr1:76189770 ACADM -0.63 -11.74 -0.42 6.16e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg04267008 chr7:1944627 MAD1L1 -0.6 -12.6 -0.45 1.13e-32 Bipolar disorder and schizophrenia; BRCA cis rs17270561 0.609 rs4712963 chr6:25740502 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 9.01 0.34 2.41e-18 Iron status biomarkers; BRCA cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.06e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs877282 0.898 rs11253340 chr10:764786 G/T cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA trans rs11098499 0.599 rs3864142 chr4:120266191 A/T cg25214090 chr10:38739885 LOC399744 0.43 9.99 0.37 6.03e-22 Corneal astigmatism; BRCA cis rs4808199 0.948 rs12982276 chr19:19459800 T/C cg03709012 chr19:19516395 GATAD2A 0.91 17.82 0.58 5.64e-58 Nonalcoholic fatty liver disease; BRCA cis rs672059 1.000 rs480132 chr1:183161779 A/G ch.1.3577855R chr1:183094577 LAMC1 0.38 8.71 0.33 2.52e-17 Hypertriglyceridemia; BRCA cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg06494592 chr3:125709126 NA -0.53 -8.18 -0.31 1.53e-15 Blood pressure (smoking interaction); BRCA cis rs9467773 0.967 rs9295694 chr6:26512994 A/T cg11502198 chr6:26597334 ABT1 0.47 9.47 0.35 5.19e-20 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.686 rs6570705 chr6:145961201 C/T cg23711669 chr6:146136114 FBXO30 0.71 17.0 0.56 8.98e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs7917772 0.582 rs4917976 chr10:104360518 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.48 -14.27 -0.49 2.71e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1215050 0.791 rs2123099 chr4:98803456 A/G cg05340658 chr4:99064831 C4orf37 0.44 10.13 0.37 1.74e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4906332 1.000 rs3783398 chr14:103949378 C/T cg26031613 chr14:104095156 KLC1 0.44 7.92 0.3 1.09e-14 Coronary artery disease; BRCA cis rs1878931 0.507 rs8054222 chr16:3413477 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.56 -9.01 -0.34 2.44e-18 Body mass index (adult); BRCA cis rs881375 0.967 rs876445 chr9:123677102 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.8 0.39 4.53e-25 Rheumatoid arthritis; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg10862848 chr6:42927986 GNMT -0.36 -15.1 -0.51 2.68e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg06484146 chr7:12443880 VWDE 0.62 9.81 0.36 3e-21 Coronary artery disease; BRCA cis rs11971779 0.618 rs10085814 chr7:139064089 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.27 0.38 5.48e-23 Diisocyanate-induced asthma; BRCA cis rs7092929 0.824 rs11251951 chr10:3622867 C/T cg14308648 chr10:3568949 NA -0.46 -8.2 -0.31 1.34e-15 Coronary artery calcification; BRCA cis rs875971 1.000 rs778726 chr7:65828731 C/T cg11764359 chr7:65958608 NA 0.8 19.53 0.61 6.05e-67 Aortic root size; BRCA cis rs4363385 0.791 rs11205177 chr1:153002502 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.37 -0.31 3.55e-16 Inflammatory skin disease; BRCA trans rs853679 0.599 rs188015 chr6:27877446 T/A cg01620082 chr3:125678407 NA -0.53 -7.84 -0.3 1.86e-14 Depression; BRCA cis rs7520050 0.966 rs785479 chr1:46492144 C/T cg24296786 chr1:45957014 TESK2 0.43 9.64 0.36 1.3e-20 Red blood cell count;Reticulocyte count; BRCA cis rs9463078 0.683 rs1342640 chr6:44743516 T/C cg25276700 chr6:44698697 NA 0.36 8.06 0.3 3.89e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs3733585 0.534 rs7375642 chr4:9955236 A/G cg26043149 chr18:55253948 FECH -0.37 -8.3 -0.31 6.41e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2479724 0.905 rs2149274 chr6:41839092 T/C cg17623882 chr6:41773611 USP49 -0.38 -10.28 -0.38 4.85e-23 Menarche (age at onset); BRCA cis rs829883 0.664 rs249833 chr12:98832189 T/C cg25150519 chr12:98850993 NA 0.66 16.05 0.54 5.72e-49 Colorectal adenoma (advanced); BRCA cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg02734326 chr4:10020555 SLC2A9 0.4 8.7 0.33 2.7e-17 Bone mineral density; BRCA cis rs1113500 0.836 rs1122158 chr1:108588668 G/T cg06207961 chr1:108661230 NA 0.4 9.58 0.35 2.03e-20 Growth-regulated protein alpha levels; BRCA cis rs2070997 0.667 rs13287613 chr9:133715291 T/C cg11464064 chr9:133710261 ABL1 0.53 9.6 0.35 1.81e-20 Response to amphetamines; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs9527 0.590 rs12414232 chr10:104914491 A/T cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.05e-24 Arsenic metabolism; BRCA cis rs6942756 1.000 rs11769045 chr7:128895335 A/G cg02491457 chr7:128862824 NA -0.7 -14.04 -0.49 3.02e-39 White matter hyperintensity burden; BRCA cis rs6433857 0.627 rs6741769 chr2:181500545 G/A cg23363182 chr2:181467187 NA -0.45 -9.73 -0.36 5.81e-21 Body mass index; BRCA cis rs7647973 0.769 rs11130181 chr3:49109919 G/A cg07636037 chr3:49044803 WDR6 0.87 20.79 0.64 9.85e-74 Menarche (age at onset); BRCA cis rs910873 0.505 rs6058099 chr20:33249134 C/T cg16810054 chr20:33298113 TP53INP2 -0.48 -10.44 -0.38 1.17e-23 Melanoma; BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg27170947 chr2:26402098 FAM59B -0.65 -11.17 -0.4 1.4e-26 Gut microbiome composition (summer); BRCA cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg08917208 chr2:24149416 ATAD2B 0.53 8.25 0.31 8.81e-16 Asthma; BRCA cis rs903263 0.601 rs34179759 chr1:84533842 G/T cg10977910 chr1:84465055 TTLL7 0.44 8.5 0.32 1.3e-16 Breast cancer (male); BRCA trans rs11098499 0.662 rs13108589 chr4:120268102 G/C cg25214090 chr10:38739885 LOC399744 0.47 10.74 0.39 7.86e-25 Corneal astigmatism; BRCA cis rs11098499 0.691 rs9996494 chr4:120238880 C/A cg09307838 chr4:120376055 NA 0.63 13.64 0.47 2.32e-37 Corneal astigmatism; BRCA cis rs4363385 0.818 rs561143 chr1:153010734 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs7103648 0.864 rs10742802 chr11:47432725 T/G cg20307385 chr11:47447363 PSMC3 0.86 26.42 0.72 1.55e-104 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.55 -0.35 2.64e-20 Tonsillectomy; BRCA cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg19784903 chr17:45786737 TBKBP1 0.36 8.48 0.32 1.56e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7818345 0.845 rs7821446 chr8:19268822 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.35 -9.15 -0.34 7.31e-19 Language performance in older adults (adjusted for episodic memory); BRCA cis rs9814567 1.000 rs9876658 chr3:134179453 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.55 0.32 9.16e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg22875332 chr1:76189707 ACADM 0.66 15.64 0.53 6.25e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 8.99 0.34 2.69e-18 Cognitive ability; BRCA cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.42 0.38 1.4e-23 IgG glycosylation; BRCA cis rs10751667 0.714 rs7933889 chr11:972270 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs6540559 0.673 rs2357230 chr1:210019498 G/A cg22029157 chr1:209979665 IRF6 0.44 8.33 0.31 4.95e-16 Cleft lip with or without cleft palate; BRCA cis rs7011049 1.000 rs72640850 chr8:53836681 A/C cg26025543 chr8:53854495 NA 0.55 9.59 0.35 1.92e-20 Systolic blood pressure; BRCA cis rs9818758 0.607 rs9855123 chr3:49229457 C/T cg00383909 chr3:49044727 WDR6 0.74 12.51 0.44 2.83e-32 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg08213375 chr14:104286397 PPP1R13B 0.63 17.61 0.57 7.19e-57 Schizophrenia; BRCA cis rs10992471 0.580 rs1535756 chr9:95202032 G/A cg14631576 chr9:95140430 CENPP -0.39 -9.31 -0.35 2.09e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg12365402 chr11:9010492 NRIP3 -0.42 -9.95 -0.37 9.05e-22 Hemoglobin concentration; BRCA cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs7809950 0.954 rs2189839 chr7:107230026 A/G cg23024343 chr7:107201750 COG5 0.39 8.87 0.33 7.04e-18 Coronary artery disease; BRCA cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs17685 0.753 rs6976532 chr7:75681094 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 4.94e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg21770322 chr7:97807741 LMTK2 0.39 10.38 0.38 1.95e-23 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg01262667 chr19:19385393 TM6SF2 0.42 10.91 0.4 1.59e-25 Tonsillectomy; BRCA cis rs3925075 1.000 rs9674009 chr16:31347541 C/A cg02846316 chr16:31340340 ITGAM 0.53 13.04 0.46 1.2e-34 IgA nephropathy; BRCA cis rs3008870 0.727 rs2755270 chr1:67474503 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.81 0.48 3.77e-38 Lymphocyte percentage of white cells; BRCA trans rs11722228 0.508 rs9732 chr4:10076658 T/C cg26043149 chr18:55253948 FECH 1.0 22.05 0.66 1.39e-80 Gout;Urate levels;Serum uric acid levels; BRCA cis rs7178424 1.000 rs7178424 chr15:62380259 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.23 -0.31 1.06e-15 Height; BRCA cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg00012203 chr2:219082015 ARPC2 -0.46 -8.77 -0.33 1.58e-17 Colorectal cancer; BRCA cis rs4718428 0.705 rs13227468 chr7:66433563 T/C cg18252515 chr7:66147081 NA -0.54 -10.76 -0.39 6.5e-25 Corneal structure; BRCA cis rs2637030 0.515 rs439552 chr5:52978517 G/A cg06476337 chr5:52856530 NDUFS4 0.36 8.28 0.31 7.15e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs28830936 1.000 rs11070343 chr15:41940146 T/A cg17847044 chr15:42102381 MAPKBP1 -0.34 -9.56 -0.35 2.4e-20 Diastolic blood pressure; BRCA cis rs6815814 0.950 rs55903115 chr4:38786474 C/A cg06935464 chr4:38784597 TLR10 0.51 8.96 0.33 3.43e-18 Breast cancer; BRCA cis rs778371 0.788 rs778355 chr2:233784749 T/G cg08000102 chr2:233561755 GIGYF2 -0.51 -9.7 -0.36 7.71e-21 Schizophrenia; BRCA cis rs2304069 0.954 rs10068537 chr5:149403193 G/A cg10852222 chr5:149380144 HMGXB3;TIGD6 0.58 8.94 0.33 4.26e-18 HIV-1 control; BRCA cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.82 -23.38 -0.68 8.2e-88 Chronic sinus infection; BRCA cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.4 8.43 0.32 2.28e-16 Schizophrenia; BRCA cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg24060327 chr5:131705240 SLC22A5 0.64 12.42 0.44 7.04e-32 Breast cancer; BRCA cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg01849466 chr14:104193079 ZFYVE21 -0.42 -11.03 -0.4 4.99e-26 Schizophrenia; BRCA cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg02659138 chr7:134003124 SLC35B4 0.34 10.79 0.39 4.94e-25 Mean platelet volume; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg24633833 chr3:10029261 TMEM111 0.41 8.02 0.3 5.1e-15 Alzheimer's disease; BRCA trans rs6582630 0.502 rs11181214 chr12:38298313 C/A cg06521331 chr12:34319734 NA -0.47 -8.73 -0.33 2.28e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs6545883 0.524 rs4599092 chr2:61498968 T/G cg15711740 chr2:61764176 XPO1 0.33 8.11 0.31 2.67e-15 Tuberculosis; BRCA cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg05872129 chr22:39784769 NA 0.58 13.27 0.46 1.16e-35 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg20203395 chr5:56204925 C5orf35 0.41 9.22 0.34 4.12e-19 Initial pursuit acceleration; BRCA cis rs10746514 0.833 rs10864720 chr1:232271232 C/T cg09506761 chr1:232265262 NA -0.42 -8.24 -0.31 9.78e-16 Response to statin therapy; BRCA cis rs11051970 0.704 rs7312698 chr12:32554695 G/T cg24626660 chr12:32551988 NA 0.32 9.4 0.35 9.38e-20 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -11.8 -0.42 3.43e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9790314 0.521 rs2122527 chr3:161091636 G/A cg04691961 chr3:161091175 C3orf57 -0.41 -9.66 -0.36 1.06e-20 Morning vs. evening chronotype; BRCA cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.23 -0.38 7.72e-23 Menarche (age at onset); BRCA cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg18876405 chr7:65276391 NA 0.52 11.63 0.42 1.7e-28 Aortic root size; BRCA cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg13256891 chr4:100009986 ADH5 0.42 9.57 0.35 2.29e-20 Alcohol dependence; BRCA cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg08045932 chr20:61659980 NA -0.42 -9.8 -0.36 3.11e-21 Prostate cancer (SNP x SNP interaction); BRCA cis rs1707322 0.827 rs12125508 chr1:46246010 A/G cg03146154 chr1:46216737 IPP 0.53 11.81 0.42 2.91e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2742234 0.590 rs2435376 chr10:43684963 A/G cg15436174 chr10:43711423 RASGEF1A -0.54 -11.11 -0.4 2.36e-26 Hirschsprung disease; BRCA trans rs1459104 1.000 rs12576386 chr11:55252365 T/G cg15704280 chr7:45808275 SEPT13 0.65 8.15 0.31 1.85e-15 Body mass index; BRCA cis rs360798 0.553 rs7562734 chr2:63047973 G/C cg17519650 chr2:63277830 OTX1 -0.38 -8.19 -0.31 1.39e-15 Coronary artery disease; BRCA cis rs12368653 0.840 rs10877020 chr12:58188014 G/A cg00677455 chr12:58241039 CTDSP2 -0.41 -9.37 -0.35 1.19e-19 Multiple sclerosis; BRCA cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.01 0.56 8.21e-54 Electrocardiographic conduction measures; BRCA cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg14343924 chr8:8086146 FLJ10661 0.41 8.55 0.32 9.27e-17 Mood instability; BRCA cis rs6121246 0.559 rs6058352 chr20:30269179 T/C cg21427119 chr20:30132790 HM13 -0.35 -7.89 -0.3 1.35e-14 Mean corpuscular hemoglobin; BRCA cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.91 -0.33 5.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1832871 0.579 rs828006 chr6:158775014 T/C cg07215822 chr6:158701037 NA 0.47 9.53 0.35 3.16e-20 Height; BRCA cis rs1144713 0.600 rs2683489 chr12:32251181 A/G cg01321189 chr12:32259338 BICD1 0.32 8.16 0.31 1.8e-15 Obesity-related traits; BRCA cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11890956 chr21:40555474 PSMG1 1.0 24.45 0.7 1.04e-93 Cognitive function; BRCA cis rs9420 0.961 rs11604333 chr11:57467035 C/G cg19752551 chr11:57585705 CTNND1 -0.51 -12.51 -0.44 2.91e-32 Schizophrenia; BRCA cis rs10883723 0.810 rs10748823 chr10:104274465 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.13 0.62 3.46e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs12950390 1.000 rs8068453 chr17:45852354 A/G cg24803719 chr17:45855879 NA 0.33 7.94 0.3 8.85e-15 IgG glycosylation; BRCA cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.1 0.56 3.05e-54 Bladder cancer; BRCA cis rs8180040 1.000 rs2159400 chr3:47375890 T/C cg27129171 chr3:47204927 SETD2 -0.69 -16.58 -0.55 1.33e-51 Colorectal cancer; BRCA cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg14349672 chr11:133703707 NA -0.4 -8.99 -0.33 2.84e-18 Childhood ear infection; BRCA cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg12463550 chr7:65579703 CRCP -0.36 -7.82 -0.3 2.2e-14 Aortic root size; BRCA cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg08045932 chr20:61659980 NA 0.49 11.32 0.41 3.36e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg23978390 chr7:1156363 C7orf50 0.42 9.62 0.36 1.44e-20 Longevity;Endometriosis; BRCA cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg05707623 chr12:122985044 ZCCHC8 -0.4 -8.53 -0.32 1.05e-16 Body mass index; BRCA cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg06766960 chr11:133703094 NA 0.59 13.01 0.46 1.77e-34 Childhood ear infection; BRCA cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg11608241 chr8:8085544 FLJ10661 0.31 8.53 0.32 1.07e-16 Mood instability; BRCA cis rs7100689 0.784 rs7089058 chr10:82071263 T/C cg01528321 chr10:82214614 TSPAN14 0.91 19.96 0.62 2.86e-69 Post bronchodilator FEV1; BRCA cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.09 0.37 2.52e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9457247 0.534 rs2345568 chr6:167381804 A/G cg23791538 chr6:167370224 RNASET2 0.52 13.11 0.46 5.8e-35 Crohn's disease; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg03923535 chr7:1197113 ZFAND2A 0.51 10.98 0.4 8.26e-26 Longevity;Endometriosis; BRCA cis rs7666738 0.518 rs13133925 chr4:98706398 G/T cg05340658 chr4:99064831 C4orf37 0.57 11.05 0.4 4.39e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg19847866 chr10:1019161 NA 0.56 12.04 0.43 2.97e-30 Response to angiotensin II receptor blocker therapy; BRCA cis rs1050631 0.623 rs7242481 chr18:33709217 G/A cg25426722 chr18:33708991 SLC39A6;ELP2 0.4 7.87 0.3 1.48e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg07395648 chr5:131743802 NA -0.36 -7.99 -0.3 6.39e-15 Breast cancer; BRCA cis rs870825 0.655 rs28451943 chr4:185645572 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA trans rs3733585 0.624 rs7376154 chr4:9952587 C/A cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2.06e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7512552 0.724 rs7002 chr1:150445819 A/G cg15654264 chr1:150340011 RPRD2 0.43 9.14 0.34 8.09e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs1215050 0.791 rs165244 chr4:98687889 C/T cg05340658 chr4:99064831 C4orf37 0.44 10.01 0.37 5.1e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 7.89 0.3 1.34e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.36 -0.38 2.27e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg18446336 chr7:2847575 GNA12 -0.35 -8.37 -0.31 3.75e-16 Height; BRCA cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg23719950 chr11:63933701 MACROD1 -0.56 -9.33 -0.35 1.65e-19 Mean platelet volume; BRCA trans rs61931739 0.517 rs7958856 chr12:34294737 T/C cg26384229 chr12:38710491 ALG10B 0.67 14.25 0.49 3.21e-40 Morning vs. evening chronotype; BRCA cis rs2980436 1 rs2980436 chr8:8092025 A/G cg08975724 chr8:8085496 FLJ10661 -0.57 -12.01 -0.43 3.98e-30 Schizophrenia; BRCA cis rs1577917 1.000 rs12216203 chr6:86675301 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.27 -0.46 1.09e-35 Response to antipsychotic treatment; BRCA cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.39 -7.97 -0.3 7.5e-15 Hematocrit; BRCA cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.7 -0.36 7.54e-21 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg13010199 chr12:38710504 ALG10B -0.38 -8.18 -0.31 1.55e-15 Bladder cancer; BRCA cis rs4363385 0.693 rs4845331 chr1:152982623 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs6901250 0.632 rs1853080 chr6:117196157 T/C cg12892004 chr6:117198278 RFX6 -0.37 -9.06 -0.34 1.57e-18 C-reactive protein levels; BRCA cis rs897984 0.542 rs73530203 chr16:31099859 G/A cg00531865 chr16:30841666 NA -0.38 -8.78 -0.33 1.49e-17 Dementia with Lewy bodies; BRCA cis rs765787 0.530 rs11070451 chr15:45533541 T/C cg24006582 chr15:45444508 DUOX1 -0.54 -11.07 -0.4 3.42e-26 Uric acid levels; BRCA trans rs79976124 0.760 rs74295030 chr6:66654441 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.82 0.39 3.75e-25 Type 2 diabetes; BRCA cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg11266682 chr4:10021025 SLC2A9 0.48 12.73 0.45 3.03e-33 Bone mineral density; BRCA cis rs1568889 0.730 rs6484350 chr11:28113658 G/A cg06544937 chr11:28130018 METT5D1;KIF18A -0.79 -20.33 -0.63 2.93e-71 Bipolar disorder; BRCA cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.8 0.39 4.41e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11583043 1.000 rs17100939 chr1:101443701 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.36 7.87 0.3 1.55e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs460214 0.528 rs4817954 chr21:40023857 C/T cg21578987 chr21:40029669 ERG 0.37 8.63 0.32 4.83e-17 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.94 0.4 1.2e-25 Rheumatoid arthritis; BRCA cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg24562669 chr7:97807699 LMTK2 0.62 18.7 0.59 1.41e-62 Breast cancer; BRCA cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.53 -0.32 1.04e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6942756 0.876 rs57263220 chr7:129010858 C/A cg02491457 chr7:128862824 NA -0.63 -12.86 -0.45 7.93e-34 White matter hyperintensity burden; BRCA cis rs1580019 1.000 rs1580019 chr7:32493169 A/T cg06627557 chr7:32535165 LSM5;AVL9 -0.82 -18.42 -0.59 4.46e-61 Cognitive ability; BRCA cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.97 0.43 5.92e-30 Lung cancer in ever smokers; BRCA cis rs7617773 0.817 rs11710861 chr3:48297560 C/T cg11946769 chr3:48343235 NME6 0.61 13.54 0.47 6.65e-37 Coronary artery disease; BRCA cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg06092702 chr1:163392909 NA -0.35 -9.57 -0.35 2.39e-20 Motion sickness; BRCA cis rs3617 0.625 rs11719137 chr3:52876389 G/T cg11645453 chr3:52864694 ITIH4 -0.38 -9.94 -0.37 9.24e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs757278 0.646 rs17140352 chr7:117344368 G/C cg10524701 chr7:117356490 CTTNBP2 0.42 7.85 0.3 1.81e-14 Response to methotrexate in juvenile idiopathic arthritis; BRCA cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.11 0.4 2.33e-26 Bipolar disorder; BRCA cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.25 0.38 6.04e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs922182 0.579 rs11856257 chr15:64239941 T/C cg24729988 chr15:64271149 DAPK2 0.49 10.74 0.39 7.31e-25 Blood protein levels; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs4906332 1.000 rs11625172 chr14:103944912 G/A cg26031613 chr14:104095156 KLC1 -0.44 -8.0 -0.3 6.01e-15 Coronary artery disease; BRCA cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg20607798 chr8:58055168 NA 0.48 8.33 0.31 4.87e-16 Developmental language disorder (linguistic errors); BRCA cis rs4660306 0.848 rs1088099 chr1:45946654 T/C cg24296786 chr1:45957014 TESK2 -0.41 -8.02 -0.3 4.93e-15 Homocysteine levels; BRCA cis rs4664304 0.620 rs11675085 chr2:160713352 C/G cg01092293 chr2:160761427 LY75 0.36 8.52 0.32 1.14e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg26597838 chr10:835615 NA 0.89 13.86 0.48 2.29e-38 Eosinophil percentage of granulocytes; BRCA cis rs965469 1.000 rs1331215 chr20:3376565 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.44 -0.38 1.19e-23 IFN-related cytopenia; BRCA cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg20476274 chr7:133979776 SLC35B4 0.6 15.08 0.51 3.63e-44 Mean platelet volume; BRCA cis rs3771570 1.000 rs62193171 chr2:242276523 C/A cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs12431939 1.000 rs7148508 chr14:51635137 G/A cg23942311 chr14:51606299 NA -0.43 -8.29 -0.31 6.89e-16 Cancer; BRCA cis rs365132 0.846 rs184784 chr5:176440229 G/T cg16309518 chr5:176445507 NA -0.4 -9.72 -0.36 6.35e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs66887589 0.616 rs13113885 chr4:120221176 G/C cg09307838 chr4:120376055 NA 0.43 8.62 0.32 5.33e-17 Diastolic blood pressure; BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26314531 chr2:26401878 FAM59B 0.82 11.34 0.41 2.76e-27 Gut microbiome composition (summer); BRCA cis rs8180040 0.934 rs62260710 chr3:47564462 C/G cg27129171 chr3:47204927 SETD2 -0.67 -14.82 -0.51 6.36e-43 Colorectal cancer; BRCA cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg20891283 chr12:69753455 YEATS4 -0.82 -27.81 -0.74 3.94e-112 Cerebrospinal fluid biomarker levels; BRCA cis rs3771570 0.901 rs3771587 chr2:242409701 A/G cg21155796 chr2:242212141 HDLBP 0.62 9.56 0.35 2.44e-20 Prostate cancer; BRCA cis rs7631605 0.905 rs9755599 chr3:37208192 T/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.87 0.36 1.69e-21 Cerebrospinal P-tau181p levels; BRCA cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg13877915 chr19:58951672 ZNF132 0.46 10.88 0.4 2.09e-25 Uric acid clearance; BRCA cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg26384229 chr12:38710491 ALG10B 0.7 15.83 0.53 7.18e-48 Bladder cancer; BRCA cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg20476274 chr7:133979776 SLC35B4 0.7 21.47 0.65 2.06e-77 Mean platelet volume; BRCA cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg16989086 chr20:62203971 PRIC285 0.52 8.77 0.33 1.63e-17 Glioblastoma; BRCA cis rs2412459 1.000 rs8023482 chr15:40307095 A/C cg10636054 chr15:40330586 SRP14 0.6 9.3 0.35 2.24e-19 Response to haloperidol in psychosis; BRCA cis rs2652822 0.525 rs8037296 chr15:63516759 A/G cg02713581 chr15:63449717 RPS27L 0.41 8.29 0.31 6.45e-16 Metabolic traits; BRCA cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg04455712 chr21:45112962 RRP1B 0.4 10.36 0.38 2.28e-23 Mean corpuscular volume; BRCA cis rs290268 1.000 rs188313 chr9:93548302 C/T cg02608019 chr9:93564028 SYK 0.54 11.8 0.42 3.37e-29 Platelet count; BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg14062083 chr21:31802829 KRTAP13-4 0.35 9.63 0.36 1.37e-20 HDL cholesterol; BRCA cis rs10992471 0.580 rs12341093 chr9:95234182 G/T cg14631576 chr9:95140430 CENPP -0.38 -9.31 -0.35 2.01e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg03929089 chr4:120376271 NA -0.68 -13.25 -0.46 1.36e-35 Coronary artery disease; BRCA cis rs10779751 0.770 rs11121696 chr1:11238063 A/G cg08854313 chr1:11322531 MTOR -0.64 -12.49 -0.44 3.44e-32 Body mass index; BRCA cis rs73242632 1.000 rs10026915 chr4:57857771 G/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.68 8.26 0.31 8.42e-16 Congenital heart disease (maternal effect); BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.09 0.34 1.24e-18 Tonsillectomy; BRCA cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg20573242 chr4:122745356 CCNA2 0.48 10.84 0.39 2.96e-25 Type 2 diabetes; BRCA trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs1401999 1.000 rs1533684 chr3:183635815 A/G cg20387954 chr3:183756860 HTR3D 0.44 9.81 0.36 3e-21 Anterior chamber depth; BRCA cis rs11051970 0.879 rs1500874 chr12:32589407 G/A cg24626660 chr12:32551988 NA 0.29 8.36 0.31 3.94e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg23978390 chr7:1156363 C7orf50 0.42 10.04 0.37 3.95e-22 Longevity;Endometriosis; BRCA cis rs1832871 0.672 rs6899322 chr6:158753669 G/T cg07165851 chr6:158734300 TULP4 0.63 12.57 0.45 1.62e-32 Height; BRCA cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.48 8.58 0.32 7.11e-17 Schizophrenia; BRCA cis rs7520050 0.808 rs11211196 chr1:46282296 A/T cg24296786 chr1:45957014 TESK2 0.44 9.83 0.36 2.51e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4285028 0.948 rs35902163 chr3:121649526 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.61 -10.76 -0.39 6.05e-25 Multiple sclerosis; BRCA trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg03929089 chr4:120376271 NA -0.6 -10.39 -0.38 1.85e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs9596863 1.000 rs9568939 chr13:54411497 A/C ch.13.53330881F chr13:54432880 NA 0.49 8.09 0.3 3.04e-15 Epilepsy and lamotrigine-induced maculopapular eruptions; BRCA cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg16950941 chr11:66035639 RAB1B 0.46 12.3 0.44 2.24e-31 Gout; BRCA cis rs9457247 0.624 rs2239826 chr6:167504880 T/C cg07741184 chr6:167504864 NA 0.38 11.06 0.4 3.78e-26 Crohn's disease; BRCA cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg00152838 chr16:24741724 TNRC6A -0.35 -7.9 -0.3 1.2e-14 Intelligence (multi-trait analysis); BRCA cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -8.27 -0.31 7.96e-16 Intelligence (multi-trait analysis); BRCA cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg16584290 chr5:462447 EXOC3 0.52 14.7 0.5 2.36e-42 Cystic fibrosis severity; BRCA cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg14664628 chr15:75095509 CSK -0.52 -12.17 -0.43 8.64e-31 Breast cancer; BRCA cis rs6582630 0.598 rs10880614 chr12:38509766 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.93 -0.37 1.07e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs9399135 0.869 rs9402675 chr6:135325794 C/G cg24558204 chr6:135376177 HBS1L 0.45 12.42 0.44 7.31e-32 Red blood cell count; BRCA cis rs9399135 0.967 rs1014020 chr6:135334426 C/A cg24558204 chr6:135376177 HBS1L 0.45 12.32 0.44 1.99e-31 Red blood cell count; BRCA cis rs7903847 0.544 rs61861865 chr10:99144867 C/G cg08345082 chr10:99160200 RRP12 -0.3 -8.68 -0.32 3.31e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.88 -15.5 -0.52 3.25e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs7914558 1.000 rs943036 chr10:104836047 T/C cg04362960 chr10:104952993 NT5C2 0.42 10.02 0.37 4.67e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1034435 0.755 rs5767173 chr22:48892473 T/C cg05992904 chr22:48892994 FAM19A5 -0.8 -20.86 -0.64 3.99e-74 Late-onset Alzheimer's disease; BRCA trans rs7980799 0.682 rs10844612 chr12:33603676 T/C cg26384229 chr12:38710491 ALG10B -0.52 -10.99 -0.4 7.56e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs61931739 0.500 rs7963282 chr12:34535255 A/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs9314101 chr5:93461593 A/T cg21475434 chr5:93447410 FAM172A 0.68 9.19 0.34 5.41e-19 Diabetic retinopathy; BRCA cis rs4073582 0.595 rs474005 chr11:66033301 C/T cg16950941 chr11:66035639 RAB1B 0.46 12.3 0.44 2.24e-31 Gout; BRCA cis rs7590368 0.926 rs12623588 chr2:10957612 C/G cg15705551 chr2:10952987 PDIA6 -0.45 -8.36 -0.31 4.04e-16 Educational attainment (years of education); BRCA cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.44 -0.32 2.09e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs8073060 0.963 rs4795082 chr17:33873501 C/T cg19694781 chr19:47549865 TMEM160 0.57 12.09 0.43 1.81e-30 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg11366901 chr6:160182831 ACAT2 0.81 15.73 0.53 2.29e-47 Age-related macular degeneration (geographic atrophy); BRCA cis rs17818399 0.962 rs7565274 chr2:46841861 G/T cg02822958 chr2:46747628 ATP6V1E2 0.52 10.04 0.37 4.02e-22 Height; BRCA cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg08917208 chr2:24149416 ATAD2B 0.87 12.43 0.44 6.24e-32 Lymphocyte counts; BRCA cis rs6433857 0.536 rs1542035 chr2:181351114 T/C cg23363182 chr2:181467187 NA -0.38 -7.93 -0.3 9.89e-15 Body mass index; BRCA cis rs6782228 0.606 rs7627549 chr3:128353079 G/A cg16766828 chr3:128327626 NA -0.43 -9.7 -0.36 7.92e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs56399783 0.901 rs73049380 chr7:2832845 C/T cg19731401 chr7:2775893 GNA12 0.49 8.15 0.31 1.9e-15 Childhood ear infection; BRCA cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs2742234 0.590 rs2435337 chr10:43661836 G/C cg15436174 chr10:43711423 RASGEF1A -0.54 -11.03 -0.4 5.02e-26 Hirschsprung disease; BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg00080972 chr5:178986291 RUFY1 0.47 12.39 0.44 9.93e-32 Lung cancer; BRCA cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg26031613 chr14:104095156 KLC1 -0.53 -9.42 -0.35 8.08e-20 Reticulocyte count; BRCA cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg05347473 chr6:146136440 FBXO30 0.43 8.67 0.32 3.67e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs861020 0.604 rs3766612 chr1:210020013 G/T cg09163369 chr1:210001066 C1orf107 -0.49 -9.76 -0.36 4.49e-21 Orofacial clefts; BRCA cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.31e-54 Bladder cancer; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg03354898 chr7:1950403 MAD1L1 -0.46 -9.19 -0.34 5.64e-19 Bipolar disorder and schizophrenia; BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg23708337 chr7:1209742 NA 0.49 8.13 0.31 2.17e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4466137 0.953 rs1585153 chr5:83000385 A/T cg15083037 chr5:83017644 HAPLN1 -0.53 -10.68 -0.39 1.28e-24 Prostate cancer; BRCA cis rs12760731 0.565 rs2095133 chr1:178198612 C/G cg00404053 chr1:178313656 RASAL2 0.64 7.9 0.3 1.2e-14 Obesity-related traits; BRCA cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg04450456 chr4:17643702 FAM184B 0.38 11.26 0.41 5.95e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.32 -0.41 3.43e-27 Uric acid levels; BRCA cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg26031613 chr14:104095156 KLC1 -0.43 -8.48 -0.32 1.58e-16 Schizophrenia; BRCA cis rs6430585 0.583 rs76097170 chr2:136593498 C/T cg07169764 chr2:136633963 MCM6 1.24 27.67 0.74 2.32e-111 Corneal structure; BRCA cis rs2243480 1.000 rs462853 chr7:65558167 G/C cg18252515 chr7:66147081 NA -1.07 -15.54 -0.52 2.03e-46 Diabetic kidney disease; BRCA cis rs1865760 0.929 rs9358896 chr6:25943197 C/A cg16482183 chr6:26056742 HIST1H1C 0.51 10.37 0.38 2.12e-23 Height; BRCA cis rs7845219 0.539 rs713113 chr8:95877787 C/T cg16049864 chr8:95962084 TP53INP1 0.4 9.58 0.35 2.14e-20 Type 2 diabetes; BRCA cis rs61990749 0.597 rs8016416 chr14:78213100 T/A cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.76 0.36 4.52e-21 Fibroblast growth factor basic levels; BRCA cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg13877915 chr19:58951672 ZNF132 0.46 10.67 0.39 1.46e-24 Uric acid clearance; BRCA cis rs8114671 0.967 rs2065979 chr20:33767690 T/C cg07148914 chr20:33460835 GGT7 0.39 8.28 0.31 7.4e-16 Height; BRCA trans rs3733585 0.631 rs4697925 chr4:10124330 G/C cg26043149 chr18:55253948 FECH -0.38 -8.09 -0.3 2.96e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9837602 1.000 rs793472 chr3:99546110 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -10.76 -0.39 6e-25 Breast cancer; BRCA cis rs501916 0.575 rs56345741 chr15:48065010 A/C cg16110827 chr15:48056943 SEMA6D -0.42 -8.88 -0.33 6.88e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.3 -0.38 4.09e-23 Psoriasis; BRCA cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.81 0.33 1.19e-17 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg03146154 chr1:46216737 IPP 0.46 10.15 0.37 1.56e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4690686 0.538 rs6855882 chr4:177261061 T/G cg17059388 chr4:177262070 NA 0.49 9.92 0.37 1.18e-21 Essential tremor; BRCA cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg13770153 chr20:60521292 NA -0.4 -8.92 -0.33 4.74e-18 Body mass index; BRCA cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg04450456 chr4:17643702 FAM184B 0.33 9.6 0.35 1.8e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg17077180 chr1:38461687 NA 0.41 8.42 0.32 2.45e-16 Coronary artery disease; BRCA cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs523522 0.923 rs3916065 chr12:120934624 A/C cg12219531 chr12:120966889 COQ5 0.55 11.42 0.41 1.25e-27 High light scatter reticulocyte count; BRCA trans rs6582630 0.519 rs12372510 chr12:38293074 T/C cg06521331 chr12:34319734 NA -0.46 -8.6 -0.32 6.31e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg07148914 chr20:33460835 GGT7 0.47 10.01 0.37 5.42e-22 Height; BRCA cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.29 0.38 4.23e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs10890381 chr1:46451771 T/G cg03146154 chr1:46216737 IPP 0.49 10.54 0.38 4.8e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17401966 1.000 rs12407992 chr1:10311983 A/C cg03954927 chr1:10346856 KIF1B 0.43 12.33 0.44 1.82e-31 Hepatocellular carcinoma; BRCA trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.92 0.3 1.09e-14 Corneal astigmatism; BRCA cis rs6456156 0.586 rs1407315 chr6:167468659 A/G cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -12.55 -0.44 1.94e-32 Bipolar disorder and schizophrenia; BRCA cis rs10499694 0.933 rs11575352 chr7:50594982 A/G cg18232548 chr7:50535776 DDC -0.39 -9.4 -0.35 9.8e-20 Body mass index; BRCA trans rs11165623 0.585 rs6698447 chr1:96999473 C/T cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.15e-30 Hip circumference;Waist circumference; BRCA cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -11.86 -0.42 1.8e-29 Joint mobility (Beighton score); BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13126279 chr21:47581558 C21orf56 0.5 10.8 0.39 4.4e-25 Testicular germ cell tumor; BRCA trans rs6089829 0.851 rs6089827 chr20:61668845 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.4 0.32 2.92e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.81 0.39 3.82e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 13.02 0.46 1.48e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.32 -0.44 1.93e-31 Bipolar disorder; BRCA cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg00339695 chr16:24857497 SLC5A11 -0.48 -9.28 -0.34 2.66e-19 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.853 rs4882054 chr11:48399899 A/G cg00717180 chr2:96193071 NA -0.28 -7.82 -0.3 2.16e-14 HDL cholesterol; BRCA cis rs4919087 1.000 rs3740512 chr10:99078745 C/T cg25902810 chr10:99078978 FRAT1 0.52 11.44 0.41 1.09e-27 Monocyte count; BRCA cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.94 -0.46 3.38e-34 Lymphocyte counts; BRCA cis rs6570726 0.791 rs1935612 chr6:145906090 T/A cg23711669 chr6:146136114 FBXO30 0.72 17.23 0.56 6.09e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs6754311 0.731 rs1470457 chr2:136581848 A/G cg25344623 chr2:136566232 LCT -0.32 -8.09 -0.3 3.1e-15 Mosquito bite size; BRCA cis rs27434 0.583 rs34759 chr5:96153133 T/C cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.2e-33 Ankylosing spondylitis; BRCA cis rs2415984 0.622 rs73245837 chr14:46947914 A/G cg14871534 chr14:47121158 RPL10L -0.32 -7.96 -0.3 7.98e-15 Number of children ever born; BRCA cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg11890956 chr21:40555474 PSMG1 1.06 30.33 0.77 7.59e-126 Cognitive function; BRCA cis rs13217239 0.646 rs10946891 chr6:26973215 T/C cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Schizophrenia; BRCA cis rs6854137 0.967 rs10033898 chr4:169734457 A/G cg20607169 chr4:169750834 PALLD -0.34 -8.1 -0.31 2.8e-15 Vein graft stenosis in coronary artery bypass grafting; BRCA cis rs7917772 0.636 rs2249845 chr10:104512095 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -10.19 -0.37 1.04e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg18351406 chr4:77819688 ANKRD56 0.57 12.65 0.45 6.54e-33 Emphysema distribution in smoking; BRCA cis rs9359856 0.564 rs17506403 chr6:90499059 C/G cg13799429 chr6:90582589 CASP8AP2 -0.67 -8.81 -0.33 1.13e-17 Bipolar disorder; BRCA cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg06092702 chr1:163392909 NA -0.36 -9.71 -0.36 6.9e-21 Motion sickness; BRCA cis rs694739 0.930 rs574087 chr11:64102948 A/G cg23796481 chr11:64053134 BAD;GPR137 0.55 11.01 0.4 5.93e-26 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs11098499 0.913 rs13126596 chr4:120140729 A/G cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.72e-26 Corneal astigmatism; BRCA cis rs4642101 0.793 rs13320486 chr3:12822069 C/A cg24848339 chr3:12840334 CAND2 0.43 11.36 0.41 2.39e-27 QRS complex (12-leadsum); BRCA cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg13256891 chr4:100009986 ADH5 0.54 9.99 0.37 6.11e-22 Smoking initiation; BRCA cis rs10751667 1.000 rs7396366 chr11:986185 C/A ch.11.42038R chr11:967971 AP2A2 0.56 17.96 0.58 1.12e-58 Alzheimer's disease (late onset); BRCA cis rs2191566 0.576 rs414402 chr19:44492568 A/G cg20607764 chr19:44506953 ZNF230 0.37 7.89 0.3 1.29e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg02475777 chr4:1388615 CRIPAK 0.38 7.82 0.3 2.27e-14 Longevity; BRCA trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg15934090 chr1:100435551 SLC35A3 0.36 8.23 0.31 1.02e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg08999081 chr20:33150536 PIGU -0.34 -8.71 -0.33 2.59e-17 Glomerular filtration rate (creatinine); BRCA cis rs2463822 1.000 rs2463820 chr11:62112290 A/T cg06239285 chr11:62104954 ASRGL1 0.63 9.24 0.34 3.67e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7927771 0.524 rs7123952 chr11:47852057 T/C cg20307385 chr11:47447363 PSMC3 0.41 9.38 0.35 1.11e-19 Subjective well-being; BRCA cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.58 -0.32 7.07e-17 Aortic root size; BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg13047869 chr3:10149882 C3orf24 0.6 12.76 0.45 2.33e-33 Alzheimer's disease; BRCA trans rs61931739 0.500 rs6488224 chr12:34537205 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg21280719 chr6:42927975 GNMT -0.33 -13.86 -0.48 2.21e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2404602 0.647 rs11072636 chr15:77185786 A/G cg23625390 chr15:77176239 SCAPER -0.56 -14.38 -0.49 7.89e-41 Blood metabolite levels; BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.55 -0.32 8.86e-17 Total body bone mineral density; BRCA cis rs921968 0.541 rs576901 chr2:219424364 A/G cg10223061 chr2:219282414 VIL1 -0.27 -8.09 -0.3 2.96e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs7666738 0.830 rs9994346 chr4:99037986 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.56 0.39 3.95e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.768 rs442405 chr6:109526980 T/G cg21918786 chr6:109611834 NA -0.34 -8.97 -0.33 3.22e-18 Reticulocyte fraction of red cells; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.09 -0.4 2.8e-26 Lymphocyte counts; BRCA cis rs10193935 0.901 rs13384323 chr2:42631346 C/T cg27598129 chr2:42591480 NA -0.72 -12.48 -0.44 3.68e-32 Colonoscopy-negative controls vs population controls; BRCA cis rs7586879 0.663 rs6760328 chr2:25077991 T/C cg04586622 chr2:25135609 ADCY3 0.37 8.54 0.32 9.82e-17 Body mass index; BRCA cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.53 -16.8 -0.55 9.57e-53 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.79 19.42 0.61 2.35e-66 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs754466 0.651 rs7895188 chr10:79623378 C/G cg17075019 chr10:79541650 NA 0.71 17.28 0.56 3.56e-55 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs2562456 0.876 rs7252585 chr19:21657943 C/T cg25042112 chr7:64838748 ZNF92 0.42 8.5 0.32 1.33e-16 Pain; BRCA cis rs7727544 0.716 rs4705928 chr5:131578637 A/G cg14196790 chr5:131705035 SLC22A5 -0.38 -9.73 -0.36 5.85e-21 Blood metabolite levels; BRCA trans rs2270927 0.510 rs10942765 chr5:75591324 G/A cg13563193 chr19:33072644 PDCD5 0.91 10.44 0.38 1.14e-23 Mean corpuscular volume; BRCA cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg18867708 chr6:26865862 GUSBL1 0.42 8.27 0.31 7.7e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg03146154 chr1:46216737 IPP -0.47 -10.38 -0.38 1.99e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9393777 0.545 rs56303243 chr6:26485727 G/A cg12826209 chr6:26865740 GUSBL1 0.56 9.17 0.34 6.34e-19 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.682 rs1337840 chr6:146042558 T/C cg23711669 chr6:146136114 FBXO30 -0.7 -16.89 -0.56 3.45e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs2243480 1.000 rs6959002 chr7:65650496 A/G cg18252515 chr7:66147081 NA 1.06 16.03 0.54 7.81e-49 Diabetic kidney disease; BRCA cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg09065629 chr16:1709722 CRAMP1L 0.37 8.65 0.32 4.27e-17 Coronary artery disease; BRCA cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg00684032 chr4:1343700 KIAA1530 0.31 8.01 0.3 5.45e-15 Obesity-related traits; BRCA cis rs68092024 0.731 rs792840 chr3:99471251 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 10.74 0.39 7.81e-25 Cleft lip with or without cleft palate; BRCA cis rs7647973 1.000 rs940045 chr3:49449638 G/A cg07636037 chr3:49044803 WDR6 0.74 16.35 0.54 1.9e-50 Menarche (age at onset); BRCA cis rs9309711 0.922 rs11679058 chr2:3483813 C/G cg10845886 chr2:3471009 TTC15 -0.82 -18.37 -0.59 7.92e-61 Neurofibrillary tangles; BRCA cis rs8062405 0.964 rs7193733 chr16:28875482 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9811920 0.770 rs4928237 chr3:99731330 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.56 -13.37 -0.47 4.18e-36 Axial length; BRCA cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg09065629 chr16:1709722 CRAMP1L 0.37 8.69 0.33 3.08e-17 Coronary artery disease; BRCA cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg04166393 chr7:2884313 GNA12 -0.62 -12.87 -0.45 7.17e-34 Height; BRCA cis rs4891159 0.548 rs690423 chr18:74117984 G/A cg24786174 chr18:74118243 ZNF516 0.84 25.71 0.71 1.21e-100 Longevity; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg16590910 chr6:42928470 GNMT 0.42 9.25 0.34 3.23e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg10802521 chr3:52805072 NEK4 -0.34 -9.25 -0.34 3.35e-19 Bipolar disorder; BRCA cis rs9304742 0.962 rs12150933 chr19:53455221 A/G cg09915433 chr19:53449742 NA -0.74 -17.02 -0.56 7.39e-54 Psoriasis; BRCA cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg23711669 chr6:146136114 FBXO30 0.8 19.26 0.61 1.59e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg21132104 chr15:45694354 SPATA5L1 0.69 13.91 0.48 1.23e-38 Homoarginine levels; BRCA cis rs8017423 1.000 rs8011810 chr14:90685669 A/G cg04374321 chr14:90722782 PSMC1 0.73 19.34 0.61 5.61e-66 Mortality in heart failure; BRCA cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg01579765 chr21:45077557 HSF2BP -0.44 -11.62 -0.42 1.92e-28 Mean corpuscular volume; BRCA cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg18252515 chr7:66147081 NA 0.52 10.32 0.38 3.33e-23 Corneal structure; BRCA cis rs919433 0.679 rs1598469 chr2:198515658 T/C cg00792783 chr2:198669748 PLCL1 0.4 9.0 0.34 2.59e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg15556689 chr8:8085844 FLJ10661 0.41 11.2 0.41 9.96e-27 Neuroticism; BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg08742575 chr21:47604166 C21orf56 0.42 8.4 0.32 2.92e-16 Testicular germ cell tumor; BRCA cis rs6545883 0.894 rs12997538 chr2:61564249 A/C cg15711740 chr2:61764176 XPO1 0.52 12.49 0.44 3.62e-32 Tuberculosis; BRCA cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg16482183 chr6:26056742 HIST1H1C 0.5 10.19 0.37 1.1e-22 Height; BRCA cis rs1865760 0.533 rs1408270 chr6:25873184 A/G cg16482183 chr6:26056742 HIST1H1C 0.58 11.22 0.41 8.4e-27 Height; BRCA cis rs6121246 0.583 rs28815498 chr20:30351560 T/C cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA cis rs11190604 1.000 rs2489043 chr10:102334327 T/C cg07080220 chr10:102295463 HIF1AN 0.57 13.33 0.47 5.94e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2880765 0.566 rs12911430 chr15:86011264 A/T cg10818794 chr15:86012489 AKAP13 -0.42 -11.14 -0.4 1.76e-26 Coronary artery disease; BRCA cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg13319975 chr6:146136371 FBXO30 -0.46 -10.47 -0.38 9.11e-24 Lobe attachment (rater-scored or self-reported); BRCA trans rs1005277 0.540 rs7903942 chr10:37929276 C/T cg17830980 chr10:43048298 ZNF37B 0.42 9.5 0.35 4.05e-20 Extrinsic epigenetic age acceleration; BRCA cis rs13053817 0.948 rs7287166 chr22:29843932 T/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.49 -9.75 -0.36 4.83e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs7395581 0.918 rs1052373 chr11:47354787 A/G cg25783544 chr11:47291846 MADD -0.41 -9.28 -0.34 2.59e-19 HDL cholesterol; BRCA trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg25517755 chr10:38738941 LOC399744 -0.37 -7.87 -0.3 1.53e-14 Corneal astigmatism; BRCA cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg12386194 chr3:101231763 SENP7 0.46 9.79 0.36 3.64e-21 Colorectal cancer; BRCA cis rs6426558 0.537 rs6699828 chr1:227274591 T/C cg10327440 chr1:227177885 CDC42BPA 0.48 9.41 0.35 9.14e-20 Neutrophil percentage of white cells; BRCA cis rs68170813 0.559 rs77641084 chr7:106970522 G/A cg02696742 chr7:106810147 HBP1 -0.56 -8.79 -0.33 1.41e-17 Coronary artery disease; BRCA cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg17971929 chr21:40555470 PSMG1 0.78 18.14 0.58 1.25e-59 Cognitive function; BRCA cis rs7582180 0.627 rs4149523 chr2:101007039 T/C cg14675211 chr2:100938903 LONRF2 0.43 9.57 0.35 2.26e-20 Intelligence (multi-trait analysis); BRCA trans rs1994135 0.608 rs1482994 chr12:33713631 T/C cg26384229 chr12:38710491 ALG10B 0.6 12.16 0.43 9.39e-31 Resting heart rate; BRCA cis rs17401966 0.522 rs6541085 chr1:10285709 A/G cg03954927 chr1:10346856 KIF1B 0.35 10.61 0.39 2.38e-24 Hepatocellular carcinoma; BRCA cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.14e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg01689657 chr7:91764605 CYP51A1 -0.22 -7.83 -0.3 2e-14 Breast cancer; BRCA cis rs6964587 0.740 rs2020360 chr7:91439506 G/C cg17063962 chr7:91808500 NA 0.5 11.28 0.41 5.07e-27 Breast cancer; BRCA cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg10224037 chr5:178157518 ZNF354A 0.63 12.02 0.43 3.73e-30 Neutrophil percentage of white cells; BRCA cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg05340658 chr4:99064831 C4orf37 0.59 12.81 0.45 1.29e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.39e-16 Colorectal cancer; BRCA trans rs11976180 1.000 rs1919951 chr7:143768891 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.21 -0.31 1.22e-15 Obesity-related traits; BRCA cis rs7246657 1.000 rs10426297 chr19:37798373 A/G cg23950597 chr19:37808831 NA -0.63 -10.93 -0.4 1.3e-25 Coronary artery calcification; BRCA cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg06784218 chr1:46089804 CCDC17 0.47 11.25 0.41 6.68e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.5 0.32 1.31e-16 Bladder cancer; BRCA cis rs7940866 0.845 rs1433976 chr11:130875123 C/T cg12179176 chr11:130786555 SNX19 -0.57 -12.42 -0.44 6.82e-32 Schizophrenia; BRCA cis rs7552404 0.855 rs385897 chr1:76106962 T/C cg10523679 chr1:76189770 ACADM -0.76 -16.11 -0.54 2.86e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4906332 1.000 rs12879663 chr14:103874215 A/G cg04998671 chr14:104000505 TRMT61A -0.41 -8.92 -0.33 4.71e-18 Coronary artery disease; BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13126279 chr21:47581558 C21orf56 -0.48 -10.75 -0.39 6.88e-25 Testicular germ cell tumor; BRCA cis rs796364 0.616 rs6718118 chr2:200691852 G/T cg23649088 chr2:200775458 C2orf69 -0.51 -7.83 -0.3 2e-14 Schizophrenia; BRCA trans rs208520 0.874 rs208515 chr6:66945749 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.45 -0.55 5.68e-51 Exhaled nitric oxide output; BRCA cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg09658497 chr7:2847517 GNA12 -0.41 -8.59 -0.32 6.86e-17 Height; BRCA trans rs3812049 0.826 rs34576922 chr5:127364103 C/G cg16011800 chr17:1958478 HIC1 0.5 8.11 0.31 2.56e-15 Lymphocyte counts;Red cell distribution width; BRCA cis rs4689388 0.926 rs28420833 chr4:6279504 G/A cg25554036 chr4:6271136 WFS1 0.43 10.46 0.38 9.97e-24 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1008375 0.618 rs13129002 chr4:17567513 A/G cg16339924 chr4:17578868 LAP3 0.56 13.35 0.47 4.69e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05039488 chr6:79577232 IRAK1BP1 0.4 8.97 0.33 3.33e-18 Endometrial cancer; BRCA cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg04450456 chr4:17643702 FAM184B 0.35 9.74 0.36 5.26e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg11707556 chr5:10655725 ANKRD33B -0.44 -10.0 -0.37 5.91e-22 Height; BRCA cis rs847577 0.508 rs12538837 chr7:97684468 C/T cg18676790 chr7:97680731 NA 0.35 7.91 0.3 1.15e-14 Breast cancer; BRCA cis rs897080 0.552 rs1067320 chr2:44633122 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.39 0.35 1.04e-19 Height; BRCA cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg22509189 chr2:225307070 NA -0.47 -9.67 -0.36 9.53e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg18357526 chr6:26021779 HIST1H4A 0.48 8.82 0.33 1.1e-17 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.966 rs2563263 chr5:140137644 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.91 -0.36 1.26e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs4363385 0.818 rs3181787 chr1:153004809 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.59 -0.32 6.67e-17 Inflammatory skin disease; BRCA cis rs7927592 0.913 rs4316515 chr11:68308840 A/T cg20283391 chr11:68216788 NA 0.45 8.96 0.33 3.67e-18 Total body bone mineral density; BRCA cis rs4363385 0.818 rs532773 chr1:153011750 T/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.27 -0.34 2.84e-19 Inflammatory skin disease; BRCA cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.31 0.49 1.69e-40 Platelet count; BRCA cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 14.17 0.49 7.83e-40 Electrocardiographic conduction measures; BRCA cis rs8180040 0.739 rs11719306 chr3:47184182 G/A cg27129171 chr3:47204927 SETD2 0.75 19.16 0.6 5.43e-65 Colorectal cancer; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.71 -0.53 2.9e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7394190 0.748 rs11000764 chr10:75506864 A/G cg07699608 chr10:75541558 CHCHD1 0.6 8.87 0.33 7.03e-18 Incident atrial fibrillation; BRCA cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg22431228 chr1:16359049 CLCNKA -0.41 -8.24 -0.31 1.01e-15 Dilated cardiomyopathy; BRCA trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21582582 chr3:182698605 DCUN1D1 0.39 10.11 0.37 2.08e-22 Intelligence (multi-trait analysis); BRCA cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg15352829 chr14:105391018 PLD4 -0.38 -12.39 -0.44 9.37e-32 Rheumatoid arthritis; BRCA cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1971762 0.583 rs2365345 chr12:54086820 C/T cg23533419 chr12:54090519 NA -0.33 -8.35 -0.31 4.36e-16 Height; BRCA cis rs6545883 0.965 rs7591345 chr2:61729641 T/A cg15711740 chr2:61764176 XPO1 -0.55 -14.03 -0.49 3.74e-39 Tuberculosis; BRCA cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7122539 0.768 rs7931485 chr11:66578635 G/A cg24851651 chr11:66362959 CCS 0.39 8.45 0.32 2.04e-16 HIV-1 susceptibility; BRCA cis rs4948102 0.731 rs4948099 chr7:56072250 A/C cg09872392 chr7:56161020 PHKG1 0.37 8.75 0.33 1.86e-17 Plasma homocysteine levels (post-methionine load test); BRCA cis rs2282526 0.615 rs162377 chr21:44926001 A/G cg04455712 chr21:45112962 RRP1B 0.35 8.2 0.31 1.36e-15 Mean corpuscular hemoglobin; BRCA cis rs2599510 0.783 rs62136349 chr2:32827504 G/A cg02381751 chr2:32503542 YIPF4 0.43 8.21 0.31 1.19e-15 Interleukin-18 levels; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg11814155 chr7:99998594 ZCWPW1 -0.49 -8.77 -0.33 1.58e-17 Platelet count; BRCA trans rs1005277 0.579 rs1780130 chr10:38485378 T/A cg17830980 chr10:43048298 ZNF37B -0.56 -13.35 -0.47 4.79e-36 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6912958 0.535 rs448580 chr6:88040399 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.4 10.99 0.4 7.67e-26 Monocyte percentage of white cells; BRCA cis rs12681288 0.676 rs2701910 chr8:1001246 G/T cg04851639 chr8:1020857 NA -0.38 -10.88 -0.4 1.99e-25 Schizophrenia; BRCA cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg00701064 chr4:6280414 WFS1 -0.67 -18.3 -0.59 1.76e-60 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2070997 0.607 rs2314342 chr9:133707362 A/G cg11464064 chr9:133710261 ABL1 0.53 9.65 0.36 1.14e-20 Response to amphetamines; BRCA cis rs561341 1.000 rs483301 chr17:30293398 G/T cg23018236 chr17:30244563 NA -0.68 -10.6 -0.39 2.7e-24 Hip circumference adjusted for BMI; BRCA cis rs9649213 0.593 rs34129434 chr7:97926464 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.58 -0.32 7.15e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.73e-18 Motion sickness; BRCA cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg22834771 chr12:69754056 YEATS4 -0.37 -9.08 -0.34 1.31e-18 Blood protein levels; BRCA cis rs66887589 0.967 rs6844263 chr4:120433807 A/G cg09307838 chr4:120376055 NA 0.45 9.3 0.35 2.14e-19 Diastolic blood pressure; BRCA cis rs1865760 1.000 rs3830057 chr6:25918510 G/T cg17691542 chr6:26056736 HIST1H1C 0.52 10.56 0.39 3.87e-24 Height; BRCA cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 17.89 0.58 2.44e-58 Age-related macular degeneration (geographic atrophy); BRCA cis rs11025559 0.631 rs11025571 chr11:20482801 C/G cg19653624 chr11:20408972 PRMT3 0.43 8.4 0.32 2.79e-16 Pursuit maintenance gain; BRCA trans rs11165623 0.792 rs2104236 chr1:96908690 C/T cg10631902 chr5:14652156 NA -0.5 -16.03 -0.54 7.01e-49 Hip circumference;Waist circumference; BRCA trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg23533926 chr12:111358616 MYL2 -0.41 -8.61 -0.32 5.77e-17 Extrinsic epigenetic age acceleration; BRCA cis rs12950390 0.776 rs4793646 chr17:45853966 A/C cg03474202 chr17:45855739 NA -0.48 -12.66 -0.45 6.03e-33 IgG glycosylation; BRCA trans rs6582630 0.555 rs2387598 chr12:38510472 G/A cg06521331 chr12:34319734 NA 0.46 9.31 0.35 2.03e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs3806843 0.933 rs2240696 chr5:140168070 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.67e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg26384229 chr12:38710491 ALG10B 0.7 15.71 0.53 2.79e-47 Bladder cancer; BRCA cis rs7927771 0.965 rs17788930 chr11:47752775 A/G cg18512352 chr11:47633146 NA -0.35 -8.52 -0.32 1.15e-16 Subjective well-being; BRCA trans rs2235573 0.551 rs139891 chr22:38387914 G/T cg19894588 chr14:64061835 NA 0.35 8.75 0.33 1.96e-17 Glioblastoma;Glioma; BRCA cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg13770153 chr20:60521292 NA -0.45 -10.79 -0.39 4.77e-25 Body mass index; BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 8.73 0.33 2.24e-17 Tonsillectomy; BRCA cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg21856205 chr7:94953877 PON1 -0.37 -8.03 -0.3 4.74e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.19 0.74 2.98e-114 Chronic sinus infection; BRCA cis rs56104184 0.830 rs17272645 chr19:49342366 C/G cg15549821 chr19:49342101 PLEKHA4 0.99 20.26 0.63 7.26e-71 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2120243 1.000 rs2120243 chr3:157147568 A/C cg01018701 chr3:157155998 VEPH1;PTX3 0.35 7.84 0.3 1.91e-14 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs796364 0.715 rs77089299 chr2:201116853 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -7.9 -0.3 1.18e-14 Schizophrenia; BRCA cis rs2979489 0.891 rs17627965 chr8:30354376 C/T cg26383811 chr8:30366931 RBPMS 0.41 9.66 0.36 1.1e-20 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs9291683 0.588 rs17246745 chr4:9994583 T/C cg11266682 chr4:10021025 SLC2A9 0.45 11.94 0.43 7.98e-30 Bone mineral density; BRCA cis rs7786808 0.741 rs11767875 chr7:158228923 A/G cg09998033 chr7:158218633 PTPRN2 -0.41 -9.6 -0.35 1.81e-20 Obesity-related traits; BRCA cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg01579765 chr21:45077557 HSF2BP -0.42 -10.86 -0.39 2.6e-25 Mean corpuscular volume; BRCA cis rs9283706 0.608 rs10060497 chr5:66332406 A/G cg11590213 chr5:66331682 MAST4 0.37 7.9 0.3 1.23e-14 Coronary artery disease; BRCA cis rs2404602 0.532 rs12591100 chr15:76700801 C/A cg23625390 chr15:77176239 SCAPER -0.43 -10.58 -0.39 3.34e-24 Blood metabolite levels; BRCA cis rs7818345 0.874 rs56298301 chr8:19305937 C/A cg11303988 chr8:19266685 CSGALNACT1 0.33 8.54 0.32 9.69e-17 Language performance in older adults (adjusted for episodic memory); BRCA cis rs17401966 0.867 rs7546364 chr1:10418815 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.57 0.47 4.97e-37 Hepatocellular carcinoma; BRCA cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg08754478 chr10:133766260 PPP2R2D -0.69 -13.87 -0.48 1.98e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2806561 0.729 rs35919647 chr1:23326072 C/T cg19743168 chr1:23544995 NA -0.4 -9.09 -0.34 1.25e-18 Height; BRCA cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg24829409 chr8:58192753 C8orf71 -0.47 -9.01 -0.34 2.38e-18 Developmental language disorder (linguistic errors); BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg10433463 chr1:1889099 KIAA1751 0.35 9.1 0.34 1.16e-18 Body mass index; BRCA cis rs6580649 0.771 rs1034762 chr12:48389643 G/T cg05342945 chr12:48394962 COL2A1 0.46 9.1 0.34 1.11e-18 Lung cancer; BRCA cis rs11252926 0.550 rs10795122 chr10:466830 C/T cg18196295 chr10:418757 DIP2C 0.48 10.87 0.4 2.24e-25 Psychosis in Alzheimer's disease; BRCA cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.34 -0.44 1.56e-31 Lymphocyte counts; BRCA trans rs7647973 0.710 rs34890793 chr3:49619493 C/T cg21659725 chr3:3221576 CRBN -0.53 -9.35 -0.35 1.44e-19 Menarche (age at onset); BRCA cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg25405998 chr7:65216604 CCT6P1 0.43 8.92 0.33 4.79e-18 Calcium levels; BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg21782813 chr7:2030301 MAD1L1 -0.32 -9.49 -0.35 4.61e-20 Bipolar disorder and schizophrenia; BRCA cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.83 0.6 2.85e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs453301 0.686 rs6987107 chr8:8893581 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -9.18 -0.34 5.93e-19 Joint mobility (Beighton score); BRCA cis rs13136331 0.532 rs2615479 chr4:88578310 C/T cg22416721 chr4:88570574 DMP1 0.58 13.97 0.48 7.11e-39 Sitting height ratio; BRCA cis rs142518269 1 rs142518269 chr2:24087095 G/A cg20701182 chr2:24300061 SF3B14 0.67 9.78 0.36 3.86e-21 Mean corpuscular hemoglobin; BRCA cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg14530993 chr4:882597 GAK 0.55 9.95 0.37 8.79e-22 Intelligence (multi-trait analysis); BRCA cis rs1499972 0.941 rs7631320 chr3:117650116 T/C cg07612923 chr3:117604196 NA 0.6 8.11 0.31 2.57e-15 Schizophrenia; BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 11.38 0.41 1.83e-27 Tonsillectomy; BRCA cis rs977987 0.806 rs4888404 chr16:75428097 G/A cg03315344 chr16:75512273 CHST6 0.53 12.55 0.44 1.91e-32 Dupuytren's disease; BRCA cis rs2839186 0.967 rs9637172 chr21:47685787 T/C cg12379764 chr21:47803548 PCNT -0.39 -8.31 -0.31 5.63e-16 Testicular germ cell tumor; BRCA cis rs6867032 0.527 rs4371796 chr5:1977785 C/T cg26168224 chr5:2018326 NA -0.51 -10.43 -0.38 1.31e-23 Gut microbiome composition (winter); BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg12444411 chr7:2802554 GNA12 -0.37 -9.3 -0.35 2.27e-19 Height; BRCA trans rs17685 0.753 rs4573217 chr7:75733946 G/A cg19862616 chr7:65841803 NCRNA00174 0.85 27.75 0.74 7.88e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11098499 0.731 rs9995026 chr4:120490499 T/A cg09307838 chr4:120376055 NA 0.68 14.12 0.49 1.28e-39 Corneal astigmatism; BRCA cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg12311346 chr5:56204834 C5orf35 0.9 17.1 0.56 3.04e-54 Initial pursuit acceleration; BRCA trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs4409675 0.576 rs2749119 chr1:28236248 G/A cg23691781 chr1:28212827 C1orf38 0.33 10.96 0.4 9.57e-26 Corneal astigmatism; BRCA cis rs7043114 0.525 rs7023004 chr9:95098712 A/G cg14631576 chr9:95140430 CENPP -0.34 -8.38 -0.31 3.3e-16 Height; BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg22920501 chr2:26401640 FAM59B -0.7 -11.53 -0.42 4.32e-28 Gut microbiome composition (summer); BRCA cis rs6545883 0.825 rs7578139 chr2:61564121 G/A cg15711740 chr2:61764176 XPO1 0.53 13.39 0.47 3.37e-36 Tuberculosis; BRCA cis rs573521 0.967 rs639752 chr11:102707339 G/T cg15619439 chr11:102700944 NA 0.29 8.4 0.32 2.82e-16 Cerebrospinal fluid levels of Alzheimer's disease-related proteins; BRCA cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg10792982 chr14:105748885 BRF1 0.48 11.25 0.41 6.68e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs35306767 0.714 rs11250228 chr10:1074887 A/G cg20503657 chr10:835505 NA 0.66 11.02 0.4 5.59e-26 Eosinophil percentage of granulocytes; BRCA cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg06064525 chr11:970664 AP2A2 -0.48 -16.04 -0.54 6.86e-49 Alzheimer's disease (late onset); BRCA cis rs7945718 0.967 rs11022490 chr11:12773526 C/G cg25843174 chr11:12811716 TEAD1 -0.23 -8.93 -0.33 4.62e-18 Educational attainment (years of education); BRCA cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg17143192 chr8:8559678 CLDN23 0.55 10.63 0.39 2.04e-24 Obesity-related traits; BRCA cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg26769984 chr7:1090371 C7orf50 0.49 9.09 0.34 1.21e-18 Bronchopulmonary dysplasia; BRCA cis rs4948102 0.824 rs11238389 chr7:56079744 A/G cg09872392 chr7:56161020 PHKG1 -0.41 -9.39 -0.35 1.03e-19 Plasma homocysteine levels (post-methionine load test); BRCA cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.09 0.37 2.64e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.07 0.34 1.49e-18 Motion sickness; BRCA cis rs7903847 0.642 rs7084654 chr10:99135262 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.63 -0.32 4.7e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.14 0.31 2.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2727020 0.757 rs7924526 chr11:49267043 G/A cg15704280 chr7:45808275 SEPT13 0.76 16.16 0.54 1.72e-49 Coronary artery disease; BRCA cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg16230307 chr14:35515116 FAM177A1 0.73 15.12 0.51 2.22e-44 Psoriasis; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg07930192 chr7:1003750 NA 0.39 8.35 0.31 4.34e-16 Longevity;Endometriosis; BRCA cis rs6952809 0.532 rs10227362 chr7:2456799 A/G cg23289794 chr7:2394357 EIF3B -0.61 -11.34 -0.41 2.89e-27 Multiple sclerosis; BRCA cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg23248424 chr5:179741104 GFPT2 -0.67 -14.18 -0.49 6.94e-40 Height; BRCA cis rs6430585 0.527 rs57530667 chr2:136444338 A/G cg07169764 chr2:136633963 MCM6 1.0 19.33 0.61 6.52e-66 Corneal structure; BRCA trans rs2204008 0.744 rs2222344 chr12:38406832 T/G cg06521331 chr12:34319734 NA -0.45 -8.4 -0.32 2.92e-16 Bladder cancer; BRCA cis rs11997175 0.624 rs4733175 chr8:33679744 T/A ch.8.33884649F chr8:33765107 NA 0.4 9.19 0.34 5.56e-19 Body mass index; BRCA cis rs17001868 0.568 rs17001846 chr22:40744053 A/G cg07138101 chr22:40742427 ADSL 0.59 11.25 0.41 6.55e-27 Mammographic density (dense area); BRCA cis rs9467773 0.549 rs9467805 chr6:26583366 C/T cg09904177 chr6:26538194 HMGN4 0.47 15.03 0.51 6.02e-44 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.81 -13.23 -0.46 1.7000000000000001e-35 Platelet count; BRCA cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.77e-26 Extrinsic epigenetic age acceleration; BRCA cis rs17401966 0.931 rs11585794 chr1:10443867 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.12 -0.31 2.34e-15 Hepatocellular carcinoma; BRCA cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.73 -0.33 2.24e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg03517284 chr6:25882590 NA -0.35 -7.92 -0.3 1.05e-14 Height; BRCA cis rs6772849 0.830 rs7633674 chr3:128355026 G/A cg16766828 chr3:128327626 NA -0.39 -8.63 -0.32 4.9e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.58 -11.81 -0.42 2.84e-29 Hip circumference adjusted for BMI; BRCA cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg18132916 chr6:79620363 NA -0.39 -7.99 -0.3 6.22e-15 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg04025307 chr7:1156635 C7orf50 0.56 13.93 0.48 1.03e-38 Longevity;Endometriosis; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg15242686 chr22:24348715 GSTTP1 0.36 8.93 0.33 4.35e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg25358565 chr5:93447407 FAM172A 1.23 19.7 0.61 7.39e-68 Diabetic retinopathy; BRCA cis rs17401966 0.964 rs17400510 chr1:10290421 T/C cg15208524 chr1:10270712 KIF1B 0.37 8.21 0.31 1.26e-15 Hepatocellular carcinoma; BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg00106254 chr7:1943704 MAD1L1 -0.4 -10.96 -0.4 1.01e-25 Bipolar disorder and schizophrenia; BRCA cis rs546131 0.928 rs535719 chr11:34853382 A/G cg06937548 chr11:34938143 PDHX;APIP 0.45 8.51 0.32 1.24e-16 Lung disease severity in cystic fibrosis; BRCA cis rs7617773 0.779 rs11718329 chr3:48309828 C/G cg11946769 chr3:48343235 NME6 0.58 12.64 0.45 7.76e-33 Coronary artery disease; BRCA cis rs7264396 0.635 rs6058365 chr20:34508092 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.9 -0.51 2.56e-43 Total cholesterol levels; BRCA cis rs10267417 0.603 rs4721836 chr7:19910497 A/G cg07541023 chr7:19748670 TWISTNB 0.45 8.21 0.31 1.25e-15 Night sleep phenotypes; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 25.68 0.71 1.87e-100 Platelet count; BRCA cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg13010199 chr12:38710504 ALG10B 0.35 8.59 0.32 6.53e-17 Morning vs. evening chronotype; BRCA trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg26384229 chr12:38710491 ALG10B 0.71 15.79 0.53 1.15e-47 Morning vs. evening chronotype; BRCA trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg03929089 chr4:120376271 NA 0.55 9.14 0.34 8.16e-19 Axial length; BRCA cis rs10504073 0.647 rs4873098 chr8:50021041 T/C cg00325661 chr8:49890786 NA 0.39 11.35 0.41 2.6e-27 Blood metabolite ratios; BRCA cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg13319975 chr6:146136371 FBXO30 -0.38 -8.76 -0.33 1.81e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg18351406 chr4:77819688 ANKRD56 0.61 13.51 0.47 9.23e-37 Emphysema distribution in smoking; BRCA cis rs11997175 0.624 rs7464055 chr8:33679382 G/A ch.8.33884649F chr8:33765107 NA 0.4 9.19 0.34 5.56e-19 Body mass index; BRCA cis rs2070488 0.745 rs9838792 chr3:38546726 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.56 -14.6 -0.5 7.2e-42 Electrocardiographic conduction measures; BRCA cis rs11098499 0.909 rs11723757 chr4:120299669 C/T cg09307838 chr4:120376055 NA 0.74 16.03 0.54 7.46e-49 Corneal astigmatism; BRCA cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.54 8.76 0.33 1.77e-17 Renal function-related traits (BUN); BRCA cis rs698813 0.703 rs2053457 chr2:44572164 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.61 11.66 0.42 1.31e-28 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg07636037 chr3:49044803 WDR6 0.52 8.72 0.33 2.42e-17 Menarche (age at onset); BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg24082983 chr21:31802169 KRTAP13-4 0.33 8.41 0.32 2.63e-16 HDL cholesterol; BRCA cis rs514406 0.505 rs405208 chr1:53176674 C/T cg08859206 chr1:53392774 SCP2 -0.42 -8.47 -0.32 1.72e-16 Monocyte count; BRCA cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg04727924 chr7:799746 HEATR2 0.55 10.22 0.37 7.9399999999999994e-23 Cerebrospinal P-tau181p levels; BRCA cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg16339924 chr4:17578868 LAP3 -0.58 -13.82 -0.48 3.49e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12618769 0.597 rs17031146 chr2:99036683 A/G cg10123293 chr2:99228465 UNC50 0.43 8.73 0.33 2.24e-17 Bipolar disorder; BRCA cis rs10197940 0.662 rs6735771 chr2:152273503 G/A cg19508488 chr2:152266495 RIF1 -0.43 -9.34 -0.35 1.63e-19 Lung cancer; BRCA cis rs1153858 1.000 rs12593230 chr15:45646968 A/T cg14582100 chr15:45693742 SPATA5L1 0.37 11.87 0.42 1.69e-29 Homoarginine levels; BRCA cis rs250677 0.687 rs36048 chr5:148441713 G/C cg12140854 chr5:148520817 ABLIM3 -0.4 -8.47 -0.32 1.71e-16 Breast cancer; BRCA cis rs151349 0.714 rs6123845 chr20:57607668 C/T cg23907860 chr20:57583709 CTSZ -0.37 -8.54 -0.32 9.56e-17 Platelet distribution width; BRCA cis rs7927771 0.826 rs2293578 chr11:47437403 C/T cg20307385 chr11:47447363 PSMC3 -0.43 -8.93 -0.33 4.63e-18 Subjective well-being; BRCA cis rs6545883 0.894 rs6760075 chr2:61612881 C/A cg15711740 chr2:61764176 XPO1 0.55 14.22 0.49 4.43e-40 Tuberculosis; BRCA cis rs7246657 0.941 rs12982333 chr19:37794724 A/G cg14683738 chr19:37701593 ZNF585B 0.5 8.57 0.32 7.72e-17 Coronary artery calcification; BRCA cis rs6142102 0.625 rs1883705 chr20:32552878 C/T cg24642439 chr20:33292090 TP53INP2 0.39 7.82 0.3 2.17e-14 Skin pigmentation; BRCA cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg03146154 chr1:46216737 IPP 0.45 10.04 0.37 4.15e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.1 0.46 6.97e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7772486 0.875 rs7739371 chr6:146424353 C/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.79 -0.33 1.36e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7395581 0.959 rs35879051 chr11:47275882 C/G cg25783544 chr11:47291846 MADD 0.43 9.49 0.35 4.43e-20 HDL cholesterol; BRCA cis rs1451375 0.583 rs7776816 chr7:50583534 G/A cg18232548 chr7:50535776 DDC 0.44 9.33 0.35 1.65e-19 Malaria; BRCA cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 11.79 0.42 3.77e-29 Mean platelet volume; BRCA cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg04727924 chr7:799746 HEATR2 -0.54 -10.52 -0.38 5.8e-24 Cerebrospinal P-tau181p levels; BRCA cis rs4919087 1.000 rs4919091 chr10:99088682 A/T cg25902810 chr10:99078978 FRAT1 -0.44 -9.25 -0.34 3.35e-19 Monocyte count; BRCA cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg22974920 chr21:40686053 BRWD1 -0.38 -8.63 -0.32 4.86e-17 Cognitive function; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg07691484 chr11:842764 TSPAN4;POLR2L -0.69 -16.29 -0.54 3.61e-50 Mean platelet volume; BRCA cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.89 0.43 1.31e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs912057 0.601 rs1294411 chr6:6739034 T/C cg06612196 chr6:6737390 NA 0.57 14.04 0.49 3.04e-39 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs6691722 0.506 rs11587667 chr1:24715435 C/G cg18323236 chr1:24743029 NIPAL3 0.37 10.24 0.38 6.71e-23 Response to interferon beta in multiple sclerosis; BRCA cis rs2070997 0.607 rs2772028 chr9:133707940 C/T cg11464064 chr9:133710261 ABL1 0.55 10.1 0.37 2.3e-22 Response to amphetamines; BRCA cis rs9325144 0.581 rs6582564 chr12:38671282 G/A cg13010199 chr12:38710504 ALG10B -0.35 -8.55 -0.32 9.32e-17 Morning vs. evening chronotype; BRCA cis rs7914558 0.902 rs7092200 chr10:104844872 T/C cg04362960 chr10:104952993 NT5C2 0.38 9.19 0.34 5.52e-19 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg10802521 chr3:52805072 NEK4 0.32 8.92 0.33 4.89e-18 Electroencephalogram traits; BRCA cis rs11105298 0.891 rs10858898 chr12:89922111 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.55 -0.35 2.81e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.3 -8.38 -0.31 3.32e-16 Lymphocyte counts; BRCA cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg26597838 chr10:835615 NA -0.52 -9.61 -0.36 1.63e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 11.07 0.4 3.38e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6430585 0.583 rs2322813 chr2:136582809 A/G cg07169764 chr2:136633963 MCM6 1.28 28.44 0.75 1.36e-115 Corneal structure; BRCA trans rs262150 0.819 rs6956589 chr7:158769301 C/T cg21167628 chr1:45308625 PTCH2 -0.32 -8.22 -0.31 1.16e-15 Facial morphology (factor 20); BRCA cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg26384229 chr12:38710491 ALG10B 0.59 15.09 0.51 3.02e-44 Morning vs. evening chronotype; BRCA cis rs2153535 0.542 rs6912740 chr6:8439959 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs912057 0.632 rs1294432 chr6:6745027 C/T cg06612196 chr6:6737390 NA 0.46 10.79 0.39 4.81e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs10911251 0.546 rs1547714 chr1:183114119 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA cis rs929596 0.785 rs17864701 chr2:234652717 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -12.28 -0.44 2.92e-31 Total bilirubin levels in HIV-1 infection; BRCA cis rs7020830 0.823 rs13285624 chr9:37129496 T/G cg14294708 chr9:37120828 ZCCHC7 1.17 40.58 0.85 5.34e-179 Schizophrenia; BRCA cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg24531977 chr5:56204891 C5orf35 0.62 12.63 0.45 8.75e-33 Coronary artery disease; BRCA cis rs9649465 1.000 rs2052128 chr7:123380405 T/A cg04330084 chr7:123175371 IQUB -0.3 -8.27 -0.31 7.73e-16 Migraine; BRCA cis rs701145 0.585 rs896013 chr3:153863873 A/G cg17054900 chr3:154042577 DHX36 0.44 8.09 0.3 2.93e-15 Coronary artery disease; BRCA cis rs2882667 0.898 rs2116789 chr5:138394262 G/T cg04439458 chr5:138467593 SIL1 -0.35 -9.55 -0.35 2.78e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs754466 0.874 rs61855849 chr10:79659934 G/A cg17075019 chr10:79541650 NA -0.69 -13.09 -0.46 7.46e-35 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg06697600 chr4:7070879 GRPEL1 0.61 10.23 0.37 7.83e-23 Monocyte percentage of white cells; BRCA cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg12311346 chr5:56204834 C5orf35 -0.62 -12.19 -0.43 7.35e-31 Type 2 diabetes; BRCA cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Urate levels; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg23358479 chr7:1110784 C7orf50 -0.47 -7.94 -0.3 9.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs16910800 0.689 rs7101737 chr11:23165031 C/T cg20040320 chr11:23191996 NA -0.55 -9.43 -0.35 7.19e-20 Cancer; BRCA cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.95 0.3 8.67e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11690935 0.550 rs62183784 chr2:172866696 A/G cg13550731 chr2:172543902 DYNC1I2 0.49 12.11 0.43 1.56e-30 Schizophrenia; BRCA cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg06618935 chr21:46677482 NA -0.37 -8.07 -0.3 3.41e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg09177884 chr7:1199841 ZFAND2A -0.42 -9.04 -0.34 1.92e-18 Longevity;Endometriosis; BRCA trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg15934090 chr1:100435551 SLC35A3 0.35 8.18 0.31 1.48e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.791 rs372490 chr1:153008971 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs4363385 0.747 rs946100 chr1:152971663 C/T cg24667326 chr1:152973720 SPRR3 0.33 9.19 0.34 5.25e-19 Inflammatory skin disease; BRCA cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.9 0.36 1.34e-21 Bladder cancer; BRCA cis rs9790314 0.663 rs778648 chr3:160708943 A/G cg03342759 chr3:160939853 NMD3 -0.46 -8.84 -0.33 9.06e-18 Morning vs. evening chronotype; BRCA cis rs8114671 0.562 rs7263157 chr20:33459127 G/A cg24642439 chr20:33292090 TP53INP2 0.41 8.13 0.31 2.24e-15 Height; BRCA cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.37 -8.07 -0.3 3.49e-15 Alzheimer's disease (late onset); BRCA cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg06552810 chr11:31128660 NA -0.39 -8.69 -0.33 3.06e-17 Red blood cell count; BRCA cis rs7927771 0.832 rs11039212 chr11:47393303 A/T cg20307385 chr11:47447363 PSMC3 0.41 8.8 0.33 1.24e-17 Subjective well-being; BRCA cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.27e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg23625390 chr15:77176239 SCAPER 0.4 9.38 0.35 1.12e-19 Blood metabolite levels; BRCA cis rs2762353 0.574 rs9467574 chr6:25705718 C/G cg03517284 chr6:25882590 NA 0.67 15.17 0.51 1.32e-44 Blood metabolite levels; BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.88 0.33 6.95e-18 Tonsillectomy; BRCA cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg04607235 chr12:12878440 APOLD1 -0.65 -10.34 -0.38 2.88e-23 Systemic lupus erythematosus; BRCA cis rs4908768 0.539 rs6666191 chr1:8658442 C/T cg20416874 chr1:8611966 RERE -0.28 -7.88 -0.3 1.43e-14 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs617791 0.530 rs7934543 chr11:65752508 G/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.48 8.78 0.33 1.52e-17 Breast cancer; BRCA cis rs929596 0.755 rs4148324 chr2:234672722 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -10.88 -0.4 2.09e-25 Total bilirubin levels in HIV-1 infection; BRCA cis rs2073300 0.609 rs6132606 chr20:23367453 G/A cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.36e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10899021 0.512 rs10219168 chr11:74374453 A/T cg25880958 chr11:74394337 NA 0.37 8.11 0.31 2.5e-15 Response to metformin (IC50); BRCA cis rs6714710 0.603 rs11123974 chr2:98605982 A/G cg26665480 chr2:98280029 ACTR1B 0.58 13.38 0.47 3.69e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg12310025 chr6:25882481 NA -1.0 -29.75 -0.76 1.03e-122 Urate levels; BRCA cis rs6714710 0.603 rs11679828 chr2:98517626 G/A cg26665480 chr2:98280029 ACTR1B 0.59 13.64 0.47 2.36e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg18305652 chr10:134549665 INPP5A 0.49 12.92 0.46 4.39e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.9 0.4 1.8e-25 Rheumatoid arthritis; BRCA cis rs6060717 0.536 rs6060670 chr20:34481143 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.08 -0.3 3.21e-15 Hip circumference adjusted for BMI; BRCA trans rs11098499 0.820 rs6829903 chr4:120506884 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.15 0.31 1.87e-15 Corneal astigmatism; BRCA cis rs1635 0.655 rs723475 chr6:28304841 G/T cg15743358 chr6:28303923 ZNF323 0.75 8.66 0.32 3.77e-17 Schizophrenia; BRCA cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.52 0.77 6.7e-127 Chronic sinus infection; BRCA cis rs921968 0.540 rs10190250 chr2:219457731 C/T cg10223061 chr2:219282414 VIL1 0.3 8.73 0.33 2.25e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs4237845 0.611 rs7298370 chr12:58318897 C/T cg00677455 chr12:58241039 CTDSP2 0.43 9.46 0.35 5.69e-20 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.875 rs163327 chr3:161062724 A/G cg04691961 chr3:161091175 C3orf57 -0.47 -11.11 -0.4 2.48e-26 Morning vs. evening chronotype; BRCA cis rs11955398 0.692 rs897672 chr5:59996101 C/G cg02684056 chr5:59996105 DEPDC1B 0.41 9.55 0.35 2.7e-20 Intelligence (multi-trait analysis); BRCA cis rs6435161 0.959 rs72926952 chr2:203485086 G/T cg18429434 chr2:203499731 FAM117B -0.43 -9.0 -0.34 2.46e-18 Total cholesterol levels; BRCA cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg00745463 chr17:30367425 LRRC37B -0.53 -8.85 -0.33 8.64e-18 Hip circumference adjusted for BMI; BRCA cis rs7560272 0.723 rs12995433 chr2:73641326 C/T cg20560298 chr2:73613845 ALMS1 0.42 11.33 0.41 2.96e-27 Schizophrenia; BRCA cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs919433 0.927 rs1429418 chr2:198158151 G/C cg00792783 chr2:198669748 PLCL1 -0.37 -7.9 -0.3 1.22e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg11764359 chr7:65958608 NA 0.74 16.46 0.55 4.94e-51 Aortic root size; BRCA cis rs1865760 0.713 rs7766342 chr6:25990674 C/A cg17691542 chr6:26056736 HIST1H1C 0.5 10.55 0.39 4.14e-24 Height; BRCA cis rs514406 0.708 rs480299 chr1:53320274 G/T cg08859206 chr1:53392774 SCP2 -0.66 -14.58 -0.5 9.07e-42 Monocyte count; BRCA cis rs2070488 0.775 rs2070489 chr3:38519424 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 16.85 0.55 5.55e-53 Electrocardiographic conduction measures; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 9.04 0.34 1.82e-18 Platelet count; BRCA cis rs4671400 0.571 rs62152275 chr2:61502238 C/A cg15711740 chr2:61764176 XPO1 0.4 7.92 0.3 1.02e-14 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg08999081 chr20:33150536 PIGU -0.45 -12.14 -0.43 1.13e-30 Glomerular filtration rate (creatinine); BRCA cis rs13082711 0.554 rs73055750 chr3:27401505 C/G cg02860705 chr3:27208620 NA 0.65 11.42 0.41 1.24e-27 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7474896 0.515 rs2738203 chr10:38277596 G/A cg25427524 chr10:38739819 LOC399744 0.58 10.0 0.37 5.69e-22 Obesity (extreme); BRCA cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg21770322 chr7:97807741 LMTK2 0.44 11.74 0.42 6.15e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg06698575 chr12:117470875 NA 0.45 7.97 0.3 7.32e-15 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg06550200 chr5:1325588 CLPTM1L 0.65 14.03 0.49 3.66e-39 Lung cancer; BRCA cis rs910316 1.000 rs175426 chr14:75624134 C/T cg23033748 chr14:75592666 NEK9 -0.44 -10.66 -0.39 1.59e-24 Height; BRCA cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 8.91e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2979489 0.786 rs2915595 chr8:30402817 A/G cg26383811 chr8:30366931 RBPMS 0.5 11.73 0.42 6.39e-29 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs7647973 1.000 rs9871024 chr3:49554241 T/C cg07636037 chr3:49044803 WDR6 -0.71 -15.29 -0.52 3.47e-45 Menarche (age at onset); BRCA cis rs9467711 0.591 rs116201501 chr6:25999149 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.24 0.34 3.63e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg21856205 chr7:94953877 PON1 -0.37 -7.89 -0.3 1.36e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.34 -0.31 4.63e-16 Monocyte percentage of white cells; BRCA cis rs910316 0.673 rs2012627 chr14:75443103 C/T cg11812906 chr14:75593930 NEK9 0.62 13.78 0.48 5.25e-38 Height; BRCA trans rs1991651 0.578 rs11778453 chr8:10489836 C/G cg15556689 chr8:8085844 FLJ10661 -0.37 -9.33 -0.35 1.69e-19 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; BRCA cis rs68170813 0.559 rs76299183 chr7:106904859 A/G cg02696742 chr7:106810147 HBP1 -0.52 -9.03 -0.34 1.96e-18 Coronary artery disease; BRCA trans rs7647973 0.588 rs4855848 chr3:49653457 C/T cg21659725 chr3:3221576 CRBN -0.48 -8.65 -0.32 4.23e-17 Menarche (age at onset); BRCA cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -18.12 -0.58 1.51e-59 Initial pursuit acceleration; BRCA cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg06453172 chr10:134556979 INPP5A -0.62 -12.15 -0.43 1.03e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10751667 0.600 rs7950955 chr11:1011490 G/A cg01483505 chr11:975446 AP2A2 0.3 7.9 0.3 1.27e-14 Alzheimer's disease (late onset); BRCA cis rs1538970 0.847 rs781230 chr1:45880751 C/T cg05343316 chr1:45956843 TESK2 -0.54 -11.17 -0.4 1.34e-26 Platelet count; BRCA cis rs523522 0.962 rs7471 chr12:120941215 T/C cg27279351 chr12:120934652 DYNLL1 0.57 13.35 0.47 4.69e-36 High light scatter reticulocyte count; BRCA cis rs1801251 1.000 rs13004406 chr2:233584557 A/T cg25237894 chr2:233734115 C2orf82 -0.4 -11.66 -0.42 1.25e-28 Coronary artery disease; BRCA cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.77 10.99 0.4 7.18e-26 Initial pursuit acceleration; BRCA cis rs9549260 0.755 rs2297627 chr13:41233931 A/G cg21288729 chr13:41239152 FOXO1 0.67 14.97 0.51 1.23e-43 Red blood cell count; BRCA cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs965469 1.000 rs6037567 chr20:3332160 C/A cg25506879 chr20:3388711 C20orf194 -0.55 -10.77 -0.39 5.7e-25 IFN-related cytopenia; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg08888203 chr3:10149979 C3orf24 0.63 11.75 0.42 5.1e-29 Alzheimer's disease; BRCA cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg05283184 chr6:79620031 NA -0.43 -10.75 -0.39 7.01e-25 Intelligence (multi-trait analysis); BRCA cis rs4588572 0.643 rs6861678 chr5:77764613 G/C cg11547950 chr5:77652471 NA -0.49 -8.54 -0.32 9.64e-17 Triglycerides; BRCA cis rs17095355 1.000 rs17095355 chr10:111735750 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.82 -0.36 2.66e-21 Biliary atresia; BRCA cis rs7577696 0.597 rs34197800 chr2:32389646 C/A cg02381751 chr2:32503542 YIPF4 -0.42 -7.91 -0.3 1.17e-14 Inflammatory biomarkers; BRCA cis rs4253772 0.550 rs9615347 chr22:46728153 A/G cg00784671 chr22:46762841 CELSR1 -0.63 -9.32 -0.35 1.85e-19 LDL cholesterol;Cholesterol, total; BRCA cis rs11662586 0.517 rs11662894 chr18:77713591 G/A cg20368463 chr18:77673604 PQLC1 0.47 11.6 0.42 2.24e-28 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs4919694 1.000 rs12254254 chr10:104765605 C/T cg04362960 chr10:104952993 NT5C2 0.94 14.64 0.5 4.47e-42 Arsenic metabolism; BRCA cis rs6973256 0.897 rs4728296 chr7:133344566 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA cis rs912057 0.833 rs1294418 chr6:6742185 A/G cg06612196 chr6:6737390 NA 0.41 9.08 0.34 1.36e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs2050392 0.799 rs303429 chr10:30708441 C/T cg18806716 chr10:30721971 MAP3K8 -0.34 -7.9 -0.3 1.25e-14 Inflammatory bowel disease; BRCA cis rs6598955 0.671 rs10902727 chr1:26597781 C/T cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.5 9.31 0.35 2.07e-19 Lung cancer in ever smokers; BRCA cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg24069376 chr3:38537580 EXOG -0.31 -8.53 -0.32 1.04e-16 Electrocardiographic conduction measures; BRCA cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08704250 chr15:31115839 NA -0.36 -8.71 -0.33 2.56e-17 Huntington's disease progression; BRCA cis rs12200560 0.505 rs1334321 chr6:97079571 C/T cg06623918 chr6:96969491 KIAA0776 -0.46 -10.61 -0.39 2.51e-24 Coronary heart disease; BRCA cis rs7267979 1.000 rs6138575 chr20:25438952 G/A cg08601574 chr20:25228251 PYGB 0.36 8.34 0.31 4.67e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs747782 0.528 rs10838881 chr11:48387275 T/C cg15704280 chr7:45808275 SEPT13 0.55 8.22 0.31 1.18e-15 Intraocular pressure; BRCA cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg10792982 chr14:105748885 BRF1 0.44 10.39 0.38 1.72e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs593982 0.719 rs11606668 chr11:65472758 A/G cg08755490 chr11:65554678 OVOL1 -1.0 -15.28 -0.52 3.55e-45 Atopic dermatitis; BRCA cis rs1865760 1.000 rs7770139 chr6:25925823 A/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.44 0.38 1.11e-23 Height; BRCA cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.49 0.32 1.42e-16 Menopause (age at onset); BRCA cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg17063962 chr7:91808500 NA 0.55 12.97 0.46 2.58e-34 Breast cancer; BRCA cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg08975724 chr8:8085496 FLJ10661 0.45 9.72 0.36 6.46e-21 Mood instability; BRCA cis rs3936840 0.647 rs942024 chr14:102979463 C/T cg18135206 chr14:102964638 TECPR2 0.5 10.75 0.39 6.66e-25 Plateletcrit; BRCA cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg13010199 chr12:38710504 ALG10B 0.56 12.22 0.44 5.11e-31 Heart rate; BRCA trans rs6951245 0.872 rs75398423 chr7:1098414 T/G cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11229555 0.574 rs11603800 chr11:58202085 A/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs11098499 0.754 rs28652763 chr4:120242312 C/T cg25214090 chr10:38739885 LOC399744 0.44 10.27 0.38 5.09e-23 Corneal astigmatism; BRCA cis rs36051895 0.623 rs1830610 chr9:5260079 C/T cg02405213 chr9:5042618 JAK2 -0.43 -8.15 -0.31 1.97e-15 Pediatric autoimmune diseases; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg00908189 chr16:619842 PIGQ 0.69 17.19 0.56 1.03e-54 Height; BRCA cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg24397884 chr7:158709396 WDR60 -0.99 -25.51 -0.71 1.62e-99 Height; BRCA cis rs7666738 0.830 rs13136930 chr4:98937933 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.86 0.55 4.66e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1878931 0.559 rs11643501 chr16:3392752 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.64 13.7 0.48 1.19e-37 Body mass index (adult); BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.22 -0.34 4.3e-19 Total body bone mineral density; BRCA cis rs8017423 0.647 rs4904680 chr14:90822075 C/T cg04374321 chr14:90722782 PSMC1 -0.47 -11.51 -0.41 5.2e-28 Mortality in heart failure; BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg09256448 chr16:638327 NA 0.3 7.89 0.3 1.28e-14 Height; BRCA cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg10556349 chr10:835070 NA 0.64 8.79 0.33 1.4e-17 Eosinophil percentage of granulocytes; BRCA cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg07148914 chr20:33460835 GGT7 0.38 8.55 0.32 8.77e-17 Height; BRCA cis rs9486719 1.000 rs2499816 chr6:96878206 C/T cg06623918 chr6:96969491 KIAA0776 0.73 12.95 0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs35740288 0.787 rs2291047 chr15:86225805 A/G cg20737812 chr15:86336631 KLHL25 -0.32 -7.86 -0.3 1.68e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA trans rs12517041 1.000 rs74322845 chr5:23293404 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA trans rs6461049 0.766 rs10256077 chr7:2171450 C/T cg04565464 chr8:145669602 NFKBIL2 -0.34 -8.18 -0.31 1.58e-15 Schizophrenia; BRCA cis rs875971 0.862 rs778736 chr7:65813848 C/T cg11764359 chr7:65958608 NA 0.76 16.74 0.55 1.98e-52 Aortic root size; BRCA cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg05347473 chr6:146136440 FBXO30 -0.43 -8.5 -0.32 1.29e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -8.03 -0.3 4.53e-15 Corneal astigmatism; BRCA cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.98 -0.37 7.05e-22 Alzheimer's disease (late onset); BRCA cis rs1568889 1.000 rs61889046 chr11:28297024 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.44 0.5 3.97e-41 Bipolar disorder; BRCA cis rs559928 0.606 rs12417635 chr11:63912728 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 11.13 0.4 2.02e-26 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA trans rs7746199 0.673 rs72845046 chr6:27575268 T/A cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.88e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg08807101 chr21:30365312 RNF160 0.77 20.27 0.63 6.04e-71 Dental caries; BRCA cis rs11718455 0.960 rs3843372 chr3:43997666 C/T cg08738300 chr3:44038990 NA 0.44 8.49 0.32 1.42e-16 Coronary artery disease; BRCA cis rs7666738 0.830 rs35560671 chr4:99069095 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs898097 0.625 rs7406464 chr17:80891460 A/G cg15664640 chr17:80829946 TBCD -0.4 -10.83 -0.39 3.22e-25 Breast cancer; BRCA trans rs877282 0.945 rs71489301 chr10:770191 A/G cg22713356 chr15:30763199 NA 1.19 23.81 0.69 3.46e-90 Uric acid levels; BRCA cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg18305652 chr10:134549665 INPP5A 0.49 11.17 0.4 1.39e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1568889 1.000 rs16917687 chr11:28062614 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.62 0.5 5.52e-42 Bipolar disorder; BRCA cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg11663144 chr21:46675770 NA -0.6 -13.81 -0.48 3.87e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg12444411 chr7:2802554 GNA12 -0.36 -8.76 -0.33 1.76e-17 Height; BRCA cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg23992470 chr4:843637 GAK 0.49 8.16 0.31 1.72e-15 Intelligence (multi-trait analysis); BRCA cis rs912330 0.529 rs4772100 chr13:99196573 G/T cg07423050 chr13:99094983 FARP1 -0.31 -7.91 -0.3 1.13e-14 Alzheimer's disease; BRCA cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg11366901 chr6:160182831 ACAT2 0.82 15.87 0.53 4.47e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs2635047 0.967 rs1119005 chr18:44725605 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 7.87 0.3 1.5e-14 Educational attainment; BRCA cis rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05901451 chr6:126070800 HEY2 -0.39 -9.53 -0.35 3.35e-20 Endometrial cancer; BRCA cis rs7647973 0.593 rs59684465 chr3:49874246 C/T cg07636037 chr3:49044803 WDR6 -0.49 -8.29 -0.31 6.85e-16 Menarche (age at onset); BRCA cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg03425785 chr20:62221387 GMEB2 0.52 8.47 0.32 1.7e-16 Glioblastoma; BRCA cis rs17092148 0.652 rs2281695 chr20:33129164 T/C cg16810054 chr20:33298113 TP53INP2 -0.45 -10.09 -0.37 2.51e-22 Neuroticism; BRCA cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg01849466 chr14:104193079 ZFYVE21 -0.47 -10.54 -0.38 4.87e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs12612619 0.732 rs4665366 chr2:27212596 G/A cg00617064 chr2:27272375 NA 0.32 8.25 0.31 8.72e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.44 0.57 5.31e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs832540 0.669 rs173764 chr5:56198920 C/T cg24531977 chr5:56204891 C5orf35 -0.64 -13.95 -0.48 8.27e-39 Coronary artery disease; BRCA cis rs561341 1.000 rs473356 chr17:30321762 G/C cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.58e-17 Hip circumference adjusted for BMI; BRCA cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg06115741 chr20:33292138 TP53INP2 -0.39 -8.54 -0.32 9.72e-17 Glomerular filtration rate (creatinine); BRCA cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -9.39 -0.35 1.08e-19 Monocyte percentage of white cells; BRCA cis rs459571 0.959 rs2520099 chr9:136918139 T/C cg13789015 chr9:136890014 NCRNA00094 0.55 11.5 0.41 6.01e-28 Platelet distribution width; BRCA cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg00409905 chr10:38381863 ZNF37A -0.49 -10.08 -0.37 2.83e-22 Extrinsic epigenetic age acceleration; BRCA cis rs2652834 1.000 rs2652832 chr15:63396928 T/C cg05507819 chr15:63340323 TPM1 0.44 7.92 0.3 1.09e-14 HDL cholesterol; BRCA cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs10484885 0.824 rs11967579 chr6:90540008 G/T cg13799429 chr6:90582589 CASP8AP2 -0.75 -9.84 -0.36 2.24e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg04455712 chr21:45112962 RRP1B 0.4 10.45 0.38 1.1e-23 Mean corpuscular volume; BRCA cis rs3008870 1.000 rs17497828 chr1:67452322 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -20.98 -0.64 9.21e-75 Lymphocyte percentage of white cells; BRCA trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg06636001 chr8:8085503 FLJ10661 0.56 11.81 0.42 2.86e-29 Neuroticism; BRCA cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg24130564 chr14:104152367 KLC1 0.35 7.91 0.3 1.12e-14 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA trans rs9858542 0.953 rs35115732 chr3:49475155 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.25 -0.34 3.26e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg06970220 chr1:156163860 SLC25A44 -0.36 -9.11 -0.34 1.04e-18 Testicular germ cell tumor; BRCA cis rs11792861 0.619 rs2289481 chr9:111712924 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 12.61 0.45 1e-32 Menarche (age at onset); BRCA cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg21856205 chr7:94953877 PON1 0.37 8.17 0.31 1.6e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg11764359 chr7:65958608 NA 0.62 13.51 0.47 9.34e-37 Calcium levels; BRCA cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg01483505 chr11:975446 AP2A2 0.33 9.04 0.34 1.84e-18 Alzheimer's disease (late onset); BRCA cis rs3925075 0.531 rs4075052 chr16:31348233 G/T cg02846316 chr16:31340340 ITGAM -0.41 -8.4 -0.32 2.98e-16 IgA nephropathy; BRCA cis rs3733585 0.631 rs4697925 chr4:10124330 G/C cg00071950 chr4:10020882 SLC2A9 -0.49 -11.23 -0.41 7.93e-27 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.28 0.31 7.32e-16 Bipolar disorder; BRCA cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg07148914 chr20:33460835 GGT7 -0.43 -9.33 -0.35 1.76e-19 Height; BRCA cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.56 11.81 0.42 3.03e-29 Monocyte percentage of white cells; BRCA cis rs2645694 0.626 rs2703129 chr4:77818548 T/C cg10057126 chr4:77819792 ANKRD56 0.66 15.36 0.52 1.54e-45 Emphysema distribution in smoking; BRCA cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.86 -0.3 1.65e-14 Axial length; BRCA cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg15212455 chr7:39170539 POU6F2 0.35 8.05 0.3 4.13e-15 IgG glycosylation; BRCA cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg26384229 chr12:38710491 ALG10B 0.82 21.94 0.66 5.8e-80 Heart rate; BRCA cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.71 -0.36 6.8e-21 Tonsillectomy; BRCA cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg08917208 chr2:24149416 ATAD2B 1.05 14.21 0.49 5.26e-40 Lymphocyte counts; BRCA cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg23711669 chr6:146136114 FBXO30 -0.78 -19.02 -0.6 2.88e-64 Lobe attachment (rater-scored or self-reported); BRCA trans rs9467711 0.606 rs35076545 chr6:26603924 C/A cg01620082 chr3:125678407 NA -0.71 -8.8 -0.33 1.28e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.66 -0.32 3.99e-17 Monocyte percentage of white cells; BRCA cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.1e-32 Developmental language disorder (linguistic errors); BRCA trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.33 9.48 0.35 4.73e-20 Intelligence (multi-trait analysis); BRCA cis rs1190552 0.894 rs2236349 chr14:102963640 G/A cg18135206 chr14:102964638 TECPR2 0.45 8.23 0.31 1.08e-15 Blood protein levels; BRCA cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs62380364 0.602 rs588282 chr5:88032651 G/T cg22951263 chr5:87985283 NA -0.38 -10.66 -0.39 1.58e-24 Intelligence (multi-trait analysis); BRCA cis rs1801251 1.000 rs6714245 chr2:233580505 T/C cg25237894 chr2:233734115 C2orf82 0.39 11.27 0.41 5.52e-27 Coronary artery disease; BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.73 -12.66 -0.45 5.95e-33 Platelet count; BRCA cis rs7927771 0.524 rs10769299 chr11:47865160 G/T cg20307385 chr11:47447363 PSMC3 0.41 9.47 0.35 5.45e-20 Subjective well-being; BRCA cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg25427524 chr10:38739819 LOC399744 0.65 15.6 0.53 9.72e-47 Extrinsic epigenetic age acceleration; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg16145915 chr7:1198662 ZFAND2A -0.47 -10.66 -0.39 1.63e-24 Longevity;Endometriosis; BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg00106254 chr7:1943704 MAD1L1 -0.46 -12.38 -0.44 1.03e-31 Bipolar disorder and schizophrenia; BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg03709012 chr19:19516395 GATAD2A 0.81 18.81 0.6 3.97e-63 Tonsillectomy; BRCA cis rs4664304 0.620 rs1828480 chr2:160720384 G/A cg14819504 chr2:160761413 LY75 0.34 8.47 0.32 1.65e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs13046373 0.508 rs1012969 chr21:31996108 G/A cg16431978 chr21:31797932 KRTAP13-3 0.35 9.01 0.34 2.42e-18 HDL cholesterol; BRCA cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg24692254 chr21:30365293 RNF160 0.62 14.25 0.49 3.16e-40 Selective IgA deficiency; BRCA cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg18230493 chr5:56204884 C5orf35 -0.62 -11.24 -0.41 7.4e-27 Initial pursuit acceleration; BRCA cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg06766960 chr11:133703094 NA 0.53 11.58 0.42 2.85e-28 Childhood ear infection; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg24642844 chr7:1081250 C7orf50 -0.56 -11.4 -0.41 1.57e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.07 0.4 3.52e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg13256891 chr4:100009986 ADH5 0.46 8.29 0.31 6.45e-16 Alcohol dependence; BRCA cis rs17685 0.712 rs56965035 chr7:75795670 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11792861 0.855 rs72607165 chr9:111814498 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.81 0.3 2.43e-14 Menarche (age at onset); BRCA cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg26343298 chr8:95960752 TP53INP1 0.3 8.74 0.33 2.07e-17 Type 2 diabetes; BRCA cis rs7914558 0.966 rs12766205 chr10:104893568 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.8 0.39 4.26e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.35e-15 Extrinsic epigenetic age acceleration; BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg22903471 chr2:27725779 GCKR -0.35 -8.52 -0.32 1.12e-16 Total body bone mineral density; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg07930192 chr7:1003750 NA 0.35 7.92 0.3 1.02e-14 Longevity;Endometriosis; BRCA cis rs778371 0.788 rs4973569 chr2:233767037 A/G cg08000102 chr2:233561755 GIGYF2 -0.64 -12.25 -0.44 3.76e-31 Schizophrenia; BRCA cis rs6878727 0.665 rs161015 chr5:123653814 G/A cg01806427 chr5:123737813 NA -0.36 -8.05 -0.3 4.17e-15 Breast cancer; BRCA cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg06064525 chr11:970664 AP2A2 -0.34 -9.9 -0.36 1.41e-21 Alzheimer's disease (late onset); BRCA cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.45e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1878931 0.555 rs27228 chr16:3431933 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.63 -9.88 -0.36 1.59e-21 Body mass index (adult); BRCA cis rs6484504 0.625 rs7112412 chr11:31370271 T/C cg26647111 chr11:31128758 NA 0.42 9.38 0.35 1.09e-19 Red blood cell count; BRCA cis rs3733585 0.699 rs6856127 chr4:9965443 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.43 -0.38 1.21e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg11941060 chr3:133502564 NA -0.51 -12.11 -0.43 1.5e-30 Iron status biomarkers; BRCA cis rs2302729 0.578 rs11062299 chr12:2771738 T/C cg19945202 chr12:2788847 CACNA1C -0.44 -9.79 -0.36 3.54e-21 Sleep quality; BRCA cis rs17270561 0.609 rs4711094 chr6:25706174 T/A cg16482183 chr6:26056742 HIST1H1C 0.42 8.19 0.31 1.44e-15 Iron status biomarkers; BRCA cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.86 -0.3 1.68e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg14019146 chr3:50243930 SLC38A3 0.37 8.99 0.34 2.73e-18 Body mass index; BRCA cis rs875971 0.965 rs28682868 chr7:65689809 C/T cg11764359 chr7:65958608 NA -0.79 -18.98 -0.6 5.11e-64 Aortic root size; BRCA cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs6479891 1.000 rs7070052 chr10:64903814 A/G cg14819942 chr15:35414228 NA -0.33 -8.37 -0.31 3.55e-16 Arthritis (juvenile idiopathic); BRCA cis rs2180341 0.960 rs7766802 chr6:127709871 T/G cg24812749 chr6:127587940 RNF146 0.84 18.89 0.6 1.45e-63 Breast cancer; BRCA cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg11189052 chr15:85197271 WDR73 -0.37 -8.93 -0.33 4.57e-18 P wave terminal force; BRCA cis rs887829 0.570 rs10171367 chr2:234597667 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.29 -0.31 6.48e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA trans rs9951602 0.573 rs78623099 chr18:76646228 G/T cg02800362 chr5:177631904 HNRNPAB 0.77 17.87 0.58 3.31e-58 Obesity-related traits; BRCA cis rs9463078 0.683 rs227841 chr6:44690309 A/T cg25276700 chr6:44698697 NA 0.38 8.31 0.31 5.74e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7766436 0.848 rs13200143 chr6:22586212 T/G cg13666174 chr6:22585274 NA -0.44 -9.52 -0.35 3.43e-20 Coronary artery disease; BRCA cis rs4481887 1.000 rs4244180 chr1:248471033 A/G cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.9e-18 Common traits (Other); BRCA cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.05 0.4 4.35e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs870825 0.929 rs72689263 chr4:185590961 C/T cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.57 -0.45 1.5e-32 Developmental language disorder (linguistic errors); BRCA cis rs7587476 0.736 rs62202002 chr2:215690600 T/C cg04004882 chr2:215674386 BARD1 0.67 12.38 0.44 1.05e-31 Neuroblastoma; BRCA cis rs2197308 0.692 rs67352173 chr12:37906912 A/T cg26384229 chr12:38710491 ALG10B 0.67 15.12 0.51 2.21e-44 Morning vs. evening chronotype; BRCA cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.28 -0.34 2.64e-19 Electroencephalogram traits; BRCA trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg15704280 chr7:45808275 SEPT13 0.62 10.28 0.38 4.74e-23 Axial length; BRCA cis rs6450176 0.909 rs6866586 chr5:53295568 A/C ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.33 -0.49 1.33e-40 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg21770322 chr7:97807741 LMTK2 0.44 11.76 0.42 4.65e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs2191566 0.576 rs402785 chr19:44492236 T/G cg20607764 chr19:44506953 ZNF230 0.37 7.98 0.3 6.59e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs6594713 0.642 rs6867579 chr5:112899573 T/C cg12552261 chr5:112820674 MCC 0.5 7.91 0.3 1.13e-14 Brain cytoarchitecture; BRCA cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg08085267 chr17:45401833 C17orf57 -0.69 -15.18 -0.51 1.18e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs62229266 0.804 rs62230822 chr21:37429945 T/C cg12218747 chr21:37451666 NA -0.35 -8.17 -0.31 1.68e-15 Mitral valve prolapse; BRCA cis rs8114671 0.967 rs6058202 chr20:33777983 A/G cg07148914 chr20:33460835 GGT7 0.37 7.87 0.3 1.51e-14 Height; BRCA cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11890956 chr21:40555474 PSMG1 1.06 30.2 0.77 3.72e-125 Cognitive function; BRCA cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs921968 0.541 rs532425 chr2:219434194 A/G cg10223061 chr2:219282414 VIL1 -0.27 -8.1 -0.31 2.71e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.53 11.92 0.43 1e-29 Colorectal cancer; BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.7 -14.39 -0.49 6.79e-41 Chronic sinus infection; BRCA cis rs2066819 1.000 rs74496027 chr12:56726340 C/T cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs7772486 0.624 rs6930154 chr6:146025662 C/T cg23711669 chr6:146136114 FBXO30 -0.7 -16.57 -0.55 1.5e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg20933634 chr6:27740509 NA 0.46 9.22 0.34 4.15e-19 Parkinson's disease; BRCA cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.28 0.44 2.88e-31 Prostate cancer (SNP x SNP interaction); BRCA trans rs35110281 0.511 rs2298562 chr21:45085236 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.07 0.3 3.37e-15 Mean corpuscular volume; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.35 -0.31 4.24e-16 Total body bone mineral density; BRCA cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.75 -0.33 1.84e-17 Aortic root size; BRCA cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg12193833 chr17:30244370 NA -0.54 -8.57 -0.32 7.97e-17 Hip circumference adjusted for BMI; BRCA cis rs7640424 0.649 rs11917909 chr3:107864673 G/A cg09227934 chr3:107805635 CD47 -0.37 -8.03 -0.3 4.6e-15 Body mass index; BRCA cis rs765787 0.530 rs2554454 chr15:45521536 A/G cg15395560 chr15:45543142 SLC28A2 0.28 7.87 0.3 1.5e-14 Uric acid levels; BRCA cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg03264133 chr6:25882463 NA 0.42 9.21 0.34 4.68e-19 Intelligence (multi-trait analysis); BRCA cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg12432903 chr7:1882776 MAD1L1 -0.45 -8.42 -0.32 2.51e-16 Bipolar disorder; BRCA cis rs9463078 0.764 rs3799968 chr6:44805377 C/T cg25276700 chr6:44698697 NA -0.36 -8.24 -0.31 9.88e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs12545109 0.765 rs2438063 chr8:57384360 A/G cg09654669 chr8:57350985 NA 0.47 9.72 0.36 6.43e-21 Obesity-related traits; BRCA cis rs12155623 0.619 rs17641604 chr8:49842784 C/T cg00325661 chr8:49890786 NA 0.33 8.57 0.32 7.8e-17 Sudden cardiac arrest; BRCA cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg13010199 chr12:38710504 ALG10B -0.39 -8.36 -0.31 3.85e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg17724175 chr1:150552817 MCL1 0.26 8.72 0.33 2.42e-17 Tonsillectomy; BRCA cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg03146154 chr1:46216737 IPP -0.47 -9.99 -0.37 6.14e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg18876405 chr7:65276391 NA -0.64 -15.91 -0.53 2.83e-48 Aortic root size; BRCA trans rs7829975 0.540 rs2976909 chr8:8346690 C/T cg02002194 chr4:3960332 NA 0.32 8.18 0.31 1.57e-15 Mood instability; BRCA cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg02017074 chr12:117425053 FBXW8 -0.58 -10.79 -0.39 4.54e-25 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg00684032 chr4:1343700 KIAA1530 -0.37 -9.49 -0.35 4.38e-20 Obesity-related traits; BRCA cis rs1843834 0.716 rs6716600 chr2:225481991 A/T cg22455342 chr2:225449267 CUL3 0.38 9.4 0.35 9.63e-20 IgE levels in asthmatics (D.p. specific); BRCA cis rs73086581 1.000 rs73086544 chr20:3950928 C/A cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs10193935 0.901 rs222486 chr2:42649664 C/T cg27598129 chr2:42591480 NA -0.81 -13.49 -0.47 1.14e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs9682041 0.627 rs34392658 chr3:170091584 C/T cg11886554 chr3:170076028 SKIL 0.49 9.93 0.37 1e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs72781680 0.678 rs11125293 chr2:24102423 A/G cg08917208 chr2:24149416 ATAD2B 0.61 10.39 0.38 1.77e-23 Lymphocyte counts; BRCA cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.34e-24 Motion sickness; BRCA cis rs912057 0.632 rs1294429 chr6:6744652 G/A cg06612196 chr6:6737390 NA 0.46 10.85 0.39 2.81e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs11758351 0.789 rs2069020 chr6:26205500 C/T cg01420254 chr6:26195488 NA 0.56 8.61 0.32 5.67e-17 Gout;Renal underexcretion gout; BRCA cis rs17270561 0.609 rs7754733 chr6:25745049 C/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg04267008 chr7:1944627 MAD1L1 -0.58 -12.14 -0.43 1.11e-30 Bipolar disorder and schizophrenia; BRCA cis rs30380 1.000 rs27529 chr5:96126308 A/G cg16492584 chr5:96139282 ERAP1 -0.31 -8.06 -0.3 3.69e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs7124681 0.565 rs2203712 chr11:47534964 T/C cg20307385 chr11:47447363 PSMC3 0.45 10.37 0.38 2.16e-23 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs1975991 0.765 rs4686941 chr3:187958554 G/A cg15417654 chr3:187959138 LPP 0.36 9.26 0.34 3.17e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs312273 0.719 rs4767995 chr12:41361851 C/T cg17827154 chr12:41323612 CNTN1 -0.39 -10.05 -0.37 3.56e-22 Bipolar disorder; BRCA cis rs61931739 0.534 rs2667447 chr12:34133468 C/A cg06521331 chr12:34319734 NA -0.61 -12.02 -0.43 3.63e-30 Morning vs. evening chronotype; BRCA cis rs6066825 0.568 rs6095245 chr20:47320770 G/C cg18078177 chr20:47281410 PREX1 0.41 10.26 0.38 5.71e-23 Colorectal cancer; BRCA cis rs796364 0.616 rs7589545 chr2:200676102 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.33 0.31 4.96e-16 Schizophrenia; BRCA trans rs3780486 0.846 rs7849148 chr9:33138352 A/T cg04842962 chr6:43655489 MRPS18A 1.12 38.92 0.84 9.6e-171 IgG glycosylation; BRCA cis rs10876993 0.784 rs10083154 chr12:58020933 G/A cg18357645 chr12:58087776 OS9 -0.42 -11.41 -0.41 1.38e-27 Celiac disease or Rheumatoid arthritis; BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg08807101 chr21:30365312 RNF160 -0.57 -13.89 -0.48 1.67e-38 Dental caries; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.87 0.69 1.58e-90 Gut microbiome composition (summer); BRCA cis rs10465746 0.905 rs34274953 chr1:84415011 G/A cg10977910 chr1:84465055 TTLL7 0.49 9.94 0.37 9.67e-22 Obesity-related traits; BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg13047869 chr3:10149882 C3orf24 0.6 12.62 0.45 9.38e-33 Alzheimer's disease; BRCA cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg00825309 chr19:58991885 ZNF446 -0.83 -19.72 -0.62 5.84e-68 Mean platelet volume; BRCA cis rs4919694 0.901 rs12251035 chr10:104671459 A/C cg04362960 chr10:104952993 NT5C2 0.98 15.23 0.52 6.73e-45 Arsenic metabolism; BRCA cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg18876405 chr7:65276391 NA -0.5 -11.21 -0.41 9.49e-27 Aortic root size; BRCA cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.58 0.42 2.8e-28 Homoarginine levels; BRCA cis rs495337 0.965 rs4809768 chr20:48576312 T/A cg17835207 chr20:48524531 SPATA2 -0.58 -13.29 -0.47 9.43e-36 Psoriasis; BRCA cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg13877915 chr19:58951672 ZNF132 0.46 10.83 0.39 3.32e-25 Uric acid clearance; BRCA cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg27541892 chr1:1571801 CDK11B -0.58 -13.2 -0.46 2.37e-35 Body mass index; BRCA cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.71 0.39 9.66e-25 Cognitive ability; BRCA trans rs12543645 0.598 rs35338507 chr8:10277982 G/A cg06636001 chr8:8085503 FLJ10661 0.47 8.63 0.32 5e-17 Schizophrenia; BRCA cis rs3784262 0.904 rs4646616 chr15:58261349 G/A cg12031962 chr15:58353849 ALDH1A2 -0.46 -12.35 -0.44 1.42e-31 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11971779 0.700 rs11763942 chr7:139005795 A/T cg07862535 chr7:139043722 LUC7L2 0.4 8.63 0.32 4.95e-17 Diisocyanate-induced asthma; BRCA cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg24060327 chr5:131705240 SLC22A5 -0.46 -9.15 -0.34 7.57e-19 Acylcarnitine levels; BRCA cis rs7264396 0.623 rs2590984 chr20:34597031 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -12.21 -0.43 5.9e-31 Total cholesterol levels; BRCA cis rs72627509 0.904 rs3796529 chr4:57797414 C/T cg26694713 chr4:57773883 REST 0.49 9.64 0.36 1.28e-20 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2762353 0.935 rs2328895 chr6:25802083 C/T cg03517284 chr6:25882590 NA -0.47 -10.66 -0.39 1.51e-24 Blood metabolite levels; BRCA cis rs4780401 0.527 rs4780402 chr16:11839809 C/T cg01061890 chr16:11836724 TXNDC11 -0.46 -9.74 -0.36 5.47e-21 Rheumatoid arthritis; BRCA cis rs35306767 0.668 rs35657988 chr10:1103590 A/G cg26597838 chr10:835615 NA 0.6 10.04 0.37 4.02e-22 Eosinophil percentage of granulocytes; BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs6450176 0.909 rs80213371 chr5:53300874 T/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.52 -0.5 1.65e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs3806843 0.766 rs801399 chr5:140034844 C/T cg16179182 chr5:140090404 VTRNA1-1 0.43 9.88 0.36 1.6e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs4925386 1.000 rs4925389 chr20:60922512 G/A cg06026331 chr20:60912101 LAMA5 -0.49 -10.18 -0.37 1.19e-22 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.39 -8.1 -0.31 2.8e-15 Alzheimer's disease (late onset); BRCA cis rs897080 0.515 rs698792 chr2:44683219 G/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.47 -8.6 -0.32 6.09e-17 Height; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg03923535 chr7:1197113 ZFAND2A 0.5 10.17 0.37 1.31e-22 Longevity;Endometriosis; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg07262247 chr5:131593730 PDLIM4 0.36 8.58 0.32 7.25e-17 Acylcarnitine levels; BRCA cis rs6570726 0.837 rs636894 chr6:145864122 T/C cg23711669 chr6:146136114 FBXO30 0.63 14.71 0.5 2.07e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg17644776 chr2:200775616 C2orf69 0.45 9.35 0.35 1.51e-19 Osteoporosis; BRCA cis rs6582630 0.519 rs11495724 chr12:38337507 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.18 0.56 1.19e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs17767294 0.614 rs72845068 chr6:27668147 A/C cg08851530 chr6:28072375 NA 1.11 10.02 0.37 4.78e-22 Parkinson's disease; BRCA trans rs79976124 0.797 rs74995761 chr6:66640216 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.77 0.39 5.51e-25 Type 2 diabetes; BRCA cis rs58785573 1.000 rs58785573 chr4:38653773 A/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.47 9.89 0.36 1.53e-21 Lymphocyte percentage of white cells; BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg05863683 chr7:1912471 MAD1L1 0.36 8.38 0.31 3.28e-16 Bipolar disorder and schizophrenia; BRCA cis rs17818399 0.926 rs35350086 chr2:46834036 C/G cg02822958 chr2:46747628 ATP6V1E2 0.56 10.24 0.38 6.6e-23 Height; BRCA cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -12.3 -0.44 2.39e-31 Personality dimensions; BRCA cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg13119609 chr19:45449297 APOC2 0.48 13.24 0.46 1.5e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.04 0.4 4.76e-26 Monocyte percentage of white cells; BRCA cis rs4891159 0.790 rs56077581 chr18:74116865 T/G cg24786174 chr18:74118243 ZNF516 -0.76 -18.69 -0.59 1.55e-62 Longevity; BRCA cis rs2625529 0.730 rs2957725 chr15:72248205 C/A cg16672083 chr15:72433130 SENP8 0.73 17.35 0.57 1.55e-55 Red blood cell count; BRCA cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg13271783 chr10:134563150 INPP5A -0.44 -8.93 -0.33 4.51e-18 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.16 0.49 8.32e-40 Platelet count; BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg00149659 chr3:10157352 C3orf10 1.06 18.2 0.58 6.23e-60 Alzheimer's disease; BRCA cis rs3741151 0.773 rs73543000 chr11:73151774 T/C cg17517138 chr11:73019481 ARHGEF17 0.87 12.41 0.44 7.71e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg17971929 chr21:40555470 PSMG1 0.7 15.48 0.52 3.79e-46 Cognitive function; BRCA cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs2637266 1.000 rs2395386 chr10:78341623 C/T cg18941641 chr10:78392320 NA 0.34 7.91 0.3 1.14e-14 Pulmonary function; BRCA cis rs68170813 0.559 rs10953531 chr7:106827867 A/G cg02696742 chr7:106810147 HBP1 0.51 8.46 0.32 1.87e-16 Coronary artery disease; BRCA cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg05973401 chr12:123451056 ABCB9 -0.41 -8.88 -0.33 6.9e-18 Height;Educational attainment;Head circumference (infant); BRCA cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.36e-31 Bipolar disorder; BRCA cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.03 22.71 0.67 3.92e-84 Gut microbiome composition (summer); BRCA cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg01689657 chr7:91764605 CYP51A1 0.22 8.17 0.31 1.63e-15 Breast cancer; BRCA cis rs758324 0.947 rs2896961 chr5:131165006 C/T cg06307176 chr5:131281290 NA 0.55 11.75 0.42 5.19e-29 Alzheimer's disease in APOE e4- carriers; BRCA cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg01483505 chr11:975446 AP2A2 0.34 9.32 0.35 1.9e-19 Alzheimer's disease (late onset); BRCA cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg12444411 chr7:2802554 GNA12 -0.32 -8.27 -0.31 7.86e-16 Height; BRCA trans rs9858542 0.953 rs7648841 chr3:49416825 G/A cg21659725 chr3:3221576 CRBN -0.46 -10.04 -0.37 4.1e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.83 0.45 1.13e-33 Bipolar disorder; BRCA cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg02297831 chr4:17616191 MED28 0.36 8.34 0.31 4.43e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9325144 0.560 rs11183090 chr12:38662293 G/C cg13010199 chr12:38710504 ALG10B -0.35 -8.54 -0.32 9.47e-17 Morning vs. evening chronotype; BRCA cis rs9467160 0.734 rs9467170 chr6:24452754 G/A cg20631270 chr6:24437470 GPLD1 0.43 7.81 0.3 2.41e-14 Liver enzyme levels; BRCA cis rs2599510 0.783 rs13399071 chr2:32793783 C/T cg02381751 chr2:32503542 YIPF4 0.43 8.53 0.32 1.07e-16 Interleukin-18 levels; BRCA cis rs3772130 0.962 rs11721291 chr3:121563285 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.82 0.39 3.58e-25 Cognitive performance; BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg13047869 chr3:10149882 C3orf24 -0.53 -9.97 -0.37 7.63e-22 Alzheimer's disease; BRCA cis rs34172651 0.874 rs200534 chr16:24752641 G/A cg04756594 chr16:24857601 SLC5A11 -0.36 -8.54 -0.32 1.01e-16 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 7.17e-41 Motion sickness; BRCA cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.51 8.06 0.3 3.82e-15 Renal function-related traits (BUN); BRCA trans rs9329221 0.935 rs6601450 chr8:10243101 G/T cg06636001 chr8:8085503 FLJ10661 0.45 9.63 0.36 1.38e-20 Neuroticism; BRCA cis rs9341808 0.617 rs9294170 chr6:80814080 A/G cg08355045 chr6:80787529 NA 0.44 11.51 0.41 5.62e-28 Sitting height ratio; BRCA cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg18876405 chr7:65276391 NA -0.55 -13.02 -0.46 1.6e-34 Aortic root size; BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 11.38 0.41 1.82e-27 Platelet count; BRCA cis rs2979489 0.891 rs6982511 chr8:30355513 G/T cg26383811 chr8:30366931 RBPMS -0.56 -13.55 -0.47 6.16e-37 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs2070488 1.000 rs13089394 chr3:38446309 C/A cg24069376 chr3:38537580 EXOG 0.4 11.31 0.41 3.69e-27 Electrocardiographic conduction measures; BRCA cis rs1344694 0.548 rs12468812 chr2:216905867 C/T cg12620499 chr2:216877984 MREG 0.53 13.17 0.46 3.35e-35 Alcohol dependence; BRCA cis rs910316 0.967 rs175451 chr14:75589729 C/T cg08847533 chr14:75593920 NEK9 -0.85 -21.51 -0.65 1.33e-77 Height; BRCA cis rs72772090 0.539 rs72773942 chr5:96123366 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg06636001 chr8:8085503 FLJ10661 0.56 12.74 0.45 2.61e-33 Mood instability; BRCA cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg13010199 chr12:38710504 ALG10B -0.44 -10.27 -0.38 5.26e-23 Heart rate; BRCA cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg08807101 chr21:30365312 RNF160 0.59 15.15 0.51 1.55e-44 Dental caries; BRCA cis rs7598759 1.000 rs7598759 chr2:232321956 C/T cg19187155 chr2:232395269 NMUR1 0.39 8.68 0.32 3.31e-17 Noise-induced hearing loss; BRCA cis rs7020830 0.830 rs13296413 chr9:37258105 C/T cg14294708 chr9:37120828 ZCCHC7 1.13 35.72 0.82 1.95e-154 Schizophrenia; BRCA cis rs611744 0.523 rs13253581 chr8:109343105 A/G cg18478394 chr8:109455254 TTC35 0.32 9.42 0.35 8.22e-20 Dupuytren's disease; BRCA cis rs11585357 0.895 rs72633808 chr1:17618665 A/G cg19159961 chr1:17633534 PADI4 0.55 8.72 0.33 2.44e-17 Hair shape; BRCA cis rs2204008 0.837 rs11168341 chr12:37961951 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.03 0.56 6.3e-54 Bladder cancer; BRCA cis rs2243480 1.000 rs7778911 chr7:65694506 T/C cg18252515 chr7:66147081 NA 1.07 15.89 0.53 3.53e-48 Diabetic kidney disease; BRCA cis rs11688816 0.569 rs7591708 chr2:63022050 T/C cg17519650 chr2:63277830 OTX1 -0.4 -8.64 -0.32 4.64e-17 Body mass index; BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg18301423 chr5:131593218 PDLIM4 0.33 8.57 0.32 7.71e-17 Breast cancer; BRCA cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg05623727 chr3:50126028 RBM5 0.41 9.68 0.36 8.68e-21 Intelligence (multi-trait analysis); BRCA cis rs1595825 0.786 rs75619425 chr2:198537281 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.08 -0.3 3.13e-15 Ulcerative colitis; BRCA cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs2625529 0.667 rs16956381 chr15:72193237 A/C cg16672083 chr15:72433130 SENP8 -0.82 -17.02 -0.56 7.35e-54 Red blood cell count; BRCA cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg26587870 chr6:27730563 NA -0.39 -8.29 -0.31 6.75e-16 Parkinson's disease; BRCA cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg24562669 chr7:97807699 LMTK2 0.47 12.54 0.44 2.15e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs3820928 0.874 rs2276593 chr2:227898434 A/G cg11843606 chr2:227700838 RHBDD1 0.37 8.17 0.31 1.65e-15 Pulmonary function; BRCA cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg20573242 chr4:122745356 CCNA2 0.49 10.92 0.4 1.45e-25 Type 2 diabetes; BRCA cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg19748678 chr4:122722346 EXOSC9 0.73 16.0 0.53 1.09e-48 Type 2 diabetes; BRCA cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg06115741 chr20:33292138 TP53INP2 -0.37 -8.32 -0.31 5.5e-16 Glomerular filtration rate (creatinine); BRCA cis rs2762353 0.902 rs3799344 chr6:25786993 C/T cg12310025 chr6:25882481 NA 0.43 10.58 0.39 3.21e-24 Blood metabolite levels; BRCA cis rs7927771 0.832 rs935914 chr11:47387599 C/T cg20307385 chr11:47447363 PSMC3 0.38 8.22 0.31 1.12e-15 Subjective well-being; BRCA cis rs724568 0.546 rs10191089 chr2:67941210 C/T cg17945962 chr2:67939740 NA -0.39 -10.56 -0.39 3.92e-24 Major depressive disorder (broad); BRCA cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg08999081 chr20:33150536 PIGU 0.37 9.4 0.35 9.56e-20 Coronary artery disease; BRCA cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg11057378 chr10:81107060 PPIF 0.36 8.88 0.33 6.98e-18 Height; BRCA cis rs4713675 0.565 rs4713670 chr6:33699882 C/T cg14003231 chr6:33640908 ITPR3 -0.34 -8.37 -0.31 3.65e-16 Plateletcrit; BRCA cis rs6594713 0.648 rs36023163 chr5:112891009 A/G cg12552261 chr5:112820674 MCC 0.5 7.91 0.3 1.13e-14 Brain cytoarchitecture; BRCA cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs9790314 0.638 rs6764019 chr3:160638851 A/C cg03342759 chr3:160939853 NMD3 0.45 8.73 0.33 2.3e-17 Morning vs. evening chronotype; BRCA trans rs60843830 1.000 rs3791224 chr2:221981 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 14.16 0.49 9.06e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs11984145 1.000 rs713243 chr7:38871105 T/C cg19327137 chr7:38886074 VPS41 0.5 7.91 0.3 1.15e-14 Cognitive performance; BRCA cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg17105886 chr17:28927953 LRRC37B2 0.62 8.17 0.31 1.67e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs12986413 0.935 rs36065733 chr19:2163771 T/G cg09261902 chr19:2140048 AP3D1 0.4 10.47 0.38 9.01e-24 Height; BRCA cis rs1865721 0.682 rs1561080 chr18:73145847 A/G cg26385618 chr18:73139727 C18orf62 -0.37 -9.31 -0.35 1.94e-19 Intelligence; BRCA cis rs10924970 1.000 rs2382567 chr1:235349803 A/G cg26050004 chr1:235667680 B3GALNT2 0.34 8.51 0.32 1.23e-16 Asthma; BRCA cis rs8114671 0.967 rs6088734 chr20:33745046 A/T cg07148914 chr20:33460835 GGT7 0.41 8.72 0.33 2.47e-17 Height; BRCA cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg17366294 chr4:99064904 C4orf37 0.41 9.39 0.35 1.01e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs4919694 1.000 rs12257935 chr10:104803062 C/A cg04362960 chr10:104952993 NT5C2 0.94 14.5 0.5 2.26e-41 Arsenic metabolism; BRCA cis rs7246657 0.639 rs12459015 chr19:38083189 T/A cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA trans rs4714291 0.832 rs9471247 chr6:40105318 A/G cg02267698 chr19:7991119 CTXN1 -0.48 -9.7 -0.36 7.32e-21 Strep throat; BRCA cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.26e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7267979 1.000 rs2257808 chr20:25266450 G/C cg08601574 chr20:25228251 PYGB 0.35 8.43 0.32 2.33e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs61931739 0.534 rs10844725 chr12:34009504 C/A cg06521331 chr12:34319734 NA -0.62 -11.22 -0.41 8.98e-27 Morning vs. evening chronotype; BRCA cis rs2415984 0.622 rs11846013 chr14:46932291 A/C cg14871534 chr14:47121158 RPL10L 0.37 8.92 0.33 4.89e-18 Number of children ever born; BRCA cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg02297831 chr4:17616191 MED28 0.37 8.55 0.32 9.34e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7249921 0.802 rs1046345 chr19:35660752 C/T cg15419183 chr19:35660584 FXYD5 0.45 10.04 0.37 3.97e-22 Platelet count; BRCA cis rs672059 1.000 rs660602 chr1:183162774 T/G ch.1.3577855R chr1:183094577 LAMC1 0.38 8.68 0.32 3.3e-17 Hypertriglyceridemia; BRCA cis rs7247513 0.964 rs4804202 chr19:12718619 T/C cg01871581 chr19:12707946 ZNF490 -0.69 -16.39 -0.54 1.22e-50 Bipolar disorder; BRCA cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg23711669 chr6:146136114 FBXO30 -0.66 -15.66 -0.53 4.98e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs765787 0.530 rs55920042 chr15:45541577 G/A cg24006582 chr15:45444508 DUOX1 -0.56 -11.57 -0.42 2.96e-28 Uric acid levels; BRCA cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg24130564 chr14:104152367 KLC1 -0.34 -7.84 -0.3 1.83e-14 Body mass index; BRCA cis rs7903847 0.596 rs11189203 chr10:99159096 C/A cg08345082 chr10:99160200 RRP12 -0.3 -8.89 -0.33 6.14e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs2243480 1.000 rs2460422 chr7:65601505 C/T cg18252515 chr7:66147081 NA -1.06 -15.58 -0.52 1.26e-46 Diabetic kidney disease; BRCA cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg08601574 chr20:25228251 PYGB -0.33 -7.97 -0.3 7.24e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11690935 0.885 rs6752812 chr2:172851502 C/A cg13550731 chr2:172543902 DYNC1I2 -0.8 -23.43 -0.68 4.13e-88 Schizophrenia; BRCA cis rs2882667 0.556 rs6873733 chr5:138403317 G/T cg04439458 chr5:138467593 SIL1 -0.29 -7.91 -0.3 1.12e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg23000734 chr10:126850823 CTBP2 -0.45 -11.95 -0.43 7.88e-30 Menarche (age at onset); BRCA cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.94 -0.51 1.6e-43 Total cholesterol levels; BRCA cis rs1538970 0.924 rs6657284 chr1:45879088 T/C cg05343316 chr1:45956843 TESK2 0.62 12.49 0.44 3.3e-32 Platelet count; BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.92 -0.3 1.05e-14 Total body bone mineral density; BRCA cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs7809950 0.678 rs12672451 chr7:106853817 C/G cg23024343 chr7:107201750 COG5 -0.45 -9.09 -0.34 1.26e-18 Coronary artery disease; BRCA cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg20701182 chr2:24300061 SF3B14 -0.7 -13.34 -0.47 5.59e-36 Lymphocyte counts; BRCA cis rs1355223 0.506 rs6484738 chr11:34860858 C/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -8.98 -0.33 3.04e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs9443645 0.527 rs4706746 chr6:79674176 G/A cg09184832 chr6:79620586 NA -0.42 -8.23 -0.31 1.04e-15 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2274471 0.645 rs3780376 chr9:5109485 G/T cg03390472 chr9:5043263 JAK2 -0.43 -8.07 -0.3 3.57e-15 Crohn's disease; BRCA cis rs7945705 0.747 rs2568020 chr11:8994715 C/T cg12365402 chr11:9010492 NRIP3 -0.44 -10.3 -0.38 4.05e-23 Hemoglobin concentration; BRCA cis rs17253792 0.822 rs80174205 chr14:56058694 T/C cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs2625529 0.824 rs4238449 chr15:72421603 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.67 -0.57 3.54e-57 Red blood cell count; BRCA cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.69 0.39 1.17e-24 Chronic sinus infection; BRCA cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg23422044 chr7:1970798 MAD1L1 -0.56 -9.62 -0.36 1.5e-20 Neuroticism; BRCA cis rs9837602 1.000 rs13064704 chr3:99767541 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.29e-26 Breast cancer; BRCA cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg24011408 chr12:48396354 COL2A1 0.57 9.48 0.35 4.93e-20 Lung cancer; BRCA cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg14983838 chr19:29218262 NA 0.5 9.86 0.36 1.91e-21 Methadone dose in opioid dependence; BRCA trans rs11722228 0.522 rs881641 chr4:10133747 G/A cg26043149 chr18:55253948 FECH 1.14 27.84 0.74 2.65e-112 Gout;Urate levels;Serum uric acid levels; BRCA trans rs7824557 0.564 rs2736295 chr8:11234780 C/G cg15556689 chr8:8085844 FLJ10661 0.34 9.1 0.34 1.14e-18 Retinal vascular caliber; BRCA cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg17724175 chr1:150552817 MCL1 0.25 8.37 0.31 3.7e-16 Urate levels; BRCA cis rs6912958 0.559 rs445434 chr6:88041849 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.43 12.11 0.43 1.57e-30 Monocyte percentage of white cells; BRCA trans rs1493916 0.748 rs1389535 chr18:31310416 A/G cg15819921 chr19:927150 ARID3A 0.43 8.35 0.31 4.08e-16 Life satisfaction; BRCA cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.33 0.49 1.33e-40 Motion sickness; BRCA cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.902 rs9863590 chr3:161116445 T/C cg04691961 chr3:161091175 C3orf57 -0.54 -12.48 -0.44 3.96e-32 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg26384229 chr12:38710491 ALG10B 0.71 16.15 0.54 1.87e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg13319975 chr6:146136371 FBXO30 0.34 7.82 0.3 2.21e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs10782582 0.592 rs7513194 chr1:76382664 A/C cg03433033 chr1:76189801 ACADM 0.39 8.22 0.31 1.11e-15 Daytime sleep phenotypes; BRCA cis rs514406 0.858 rs574853 chr1:53310959 A/T cg08859206 chr1:53392774 SCP2 -0.51 -11.23 -0.41 7.76e-27 Monocyte count; BRCA cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11644478 chr21:40555479 PSMG1 0.83 18.81 0.6 3.63e-63 Cognitive function; BRCA trans rs35110281 0.627 rs56369437 chr21:44970275 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.81 0.33 1.18e-17 Mean corpuscular volume; BRCA cis rs7582180 0.629 rs11678148 chr2:100966950 A/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.87 -0.3 1.48e-14 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.93 0.56 2.16e-53 Bladder cancer; BRCA cis rs6598955 0.671 rs57386998 chr1:26569821 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs1568889 1.000 rs11603799 chr11:28196488 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.8 0.51 8.3e-43 Bipolar disorder; BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.57 -11.52 -0.41 4.97e-28 Tonsillectomy; BRCA trans rs208520 0.754 rs7753158 chr6:66875633 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -18.58 -0.59 6.47e-62 Exhaled nitric oxide output; BRCA cis rs10838687 0.736 rs4647726 chr11:47245494 A/T cg25783544 chr11:47291846 MADD 0.43 7.86 0.3 1.63e-14 Proinsulin levels; BRCA cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg05347473 chr6:146136440 FBXO30 0.6 11.44 0.41 1.1e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg15541040 chr2:3486749 NA -0.47 -10.42 -0.38 1.39e-23 Neurofibrillary tangles; BRCA cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs10870270 0.956 rs4131689 chr10:133744328 A/C cg08754478 chr10:133766260 PPP2R2D 0.68 14.1 0.49 1.64e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg11657440 chr19:46296263 DMWD 0.7 18.48 0.59 2e-61 Coronary artery disease; BRCA cis rs2050392 0.624 rs303444 chr10:30729347 C/T cg18806716 chr10:30721971 MAP3K8 -0.6 -13.97 -0.48 6.51e-39 Inflammatory bowel disease; BRCA trans rs2262909 1.000 rs436039 chr19:22214873 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -7.81 -0.3 2.39e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs1878931 0.615 rs4786412 chr16:3440390 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.98 26.53 0.72 4.11e-105 Body mass index (adult); BRCA cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg11764359 chr7:65958608 NA 0.76 17.07 0.56 4.29e-54 Aortic root size; BRCA cis rs477692 1.000 rs538969 chr10:131410608 C/T cg05714579 chr10:131428358 MGMT 0.55 13.01 0.46 1.78e-34 Response to temozolomide; BRCA cis rs9341808 0.667 rs3805913 chr6:80927322 A/G cg08355045 chr6:80787529 NA 0.32 7.86 0.3 1.64e-14 Sitting height ratio; BRCA cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg19748678 chr4:122722346 EXOSC9 0.74 15.96 0.53 1.71e-48 Type 2 diabetes; BRCA cis rs7119038 0.818 rs6589684 chr11:118610957 A/G cg19308663 chr11:118741387 NA -0.4 -9.37 -0.35 1.21e-19 Sjögren's syndrome; BRCA trans rs2235573 0.551 rs139892 chr22:38388203 C/T cg19894588 chr14:64061835 NA 0.36 8.68 0.32 3.34e-17 Glioblastoma;Glioma; BRCA cis rs61931739 0.517 rs1844525 chr12:34103183 T/A cg06521331 chr12:34319734 NA -0.62 -11.18 -0.4 1.22e-26 Morning vs. evening chronotype; BRCA cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 14.19 0.49 6.03e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg12011299 chr4:100065546 ADH4 0.42 10.56 0.39 3.95e-24 Alcohol dependence; BRCA cis rs6460942 0.915 rs7809263 chr7:12450589 C/G cg06484146 chr7:12443880 VWDE -0.63 -9.49 -0.35 4.59e-20 Coronary artery disease; BRCA cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg02524346 chr8:600233 NA -0.74 -9.11 -0.34 1.08e-18 IgG glycosylation; BRCA cis rs10883723 0.810 rs11191304 chr10:104255284 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg00825309 chr19:58991885 ZNF446 -0.59 -12.88 -0.45 6.82e-34 Uric acid clearance; BRCA cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -8.01 -0.3 5.43e-15 Platelet count; BRCA cis rs11229555 0.574 rs66573492 chr11:58183797 G/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg10792982 chr14:105748885 BRF1 0.4 9.76 0.36 4.58e-21 Mean platelet volume;Platelet distribution width; BRCA cis rs1109501 1.000 rs1109501 chr4:71329490 G/A cg22786090 chr4:71381880 NA 0.37 7.85 0.3 1.77e-14 Alcoholism (heaviness of drinking); BRCA cis rs698833 0.852 rs4953092 chr2:44565293 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.54 11.25 0.41 6.6e-27 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg10792982 chr14:105748885 BRF1 0.5 11.25 0.41 6.71e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs6450176 1.000 rs60492935 chr5:53306240 G/T ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.32 -0.52 2.36e-45 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11644478 chr21:40555479 PSMG1 -0.7 -16.04 -0.54 6.27e-49 Cognitive function; BRCA cis rs13046373 0.508 rs1507393 chr21:31992779 A/G cg22337977 chr21:31811175 KRTAP15-1 0.33 7.92 0.3 1.05e-14 HDL cholesterol; BRCA cis rs9815354 0.812 rs74947509 chr3:42006323 T/C cg03022575 chr3:42003672 ULK4 0.65 9.49 0.35 4.62e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs11711311 1.000 rs2603792 chr3:113509187 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.7 -0.39 1.09e-24 IgG glycosylation; BRCA cis rs28374715 0.662 rs28827035 chr15:41492290 G/A cg18705301 chr15:41695430 NDUFAF1 -0.87 -18.09 -0.58 2.39e-59 Ulcerative colitis; BRCA cis rs4566357 0.557 rs2272201 chr2:227912551 T/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.44 -0.35 6.61e-20 Coronary artery disease; BRCA cis rs559928 0.606 rs78038516 chr11:63978067 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 11.44 0.41 1.07e-27 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg22467129 chr15:76604101 ETFA -0.49 -10.82 -0.39 3.71e-25 Blood metabolite levels; BRCA cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg23711669 chr6:146136114 FBXO30 0.75 17.43 0.57 6.04e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg16586182 chr3:47516702 SCAP -0.43 -8.84 -0.33 9.49e-18 Birth weight; BRCA cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs7953508 0.659 rs1316739 chr12:93968256 G/A cg18151635 chr12:93972918 NA -0.43 -9.09 -0.34 1.21e-18 Pubertal anthropometrics; BRCA cis rs875971 1.000 rs709597 chr7:65825983 A/G cg12463550 chr7:65579703 CRCP -0.37 -7.89 -0.3 1.33e-14 Aortic root size; BRCA cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.57 0.45 1.51e-32 Electroencephalogram traits; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.27 -0.31 7.74e-16 Total body bone mineral density; BRCA cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg01448562 chr3:133502909 NA 0.73 17.48 0.57 3.26e-56 Iron status biomarkers; BRCA cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.66 -14.67 -0.5 3.19e-42 Chronic sinus infection; BRCA cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg13319975 chr6:146136371 FBXO30 0.4 9.32 0.35 1.81e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6940638 0.662 rs6915678 chr6:27235866 T/G cg12292205 chr6:26970375 C6orf41 -0.44 -9.06 -0.34 1.55e-18 Intelligence (multi-trait analysis); BRCA trans rs208515 0.556 rs12206707 chr6:66697182 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 15.89 0.53 3.85e-48 Exhaled nitric oxide levels; BRCA cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg23711669 chr6:146136114 FBXO30 0.73 15.2 0.52 8.77e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs243505 1.000 rs243514 chr7:148427873 A/G cg09806900 chr7:148480153 CUL1 0.4 8.32 0.31 5.43e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.64 0.36 1.22e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg13319975 chr6:146136371 FBXO30 -0.34 -7.91 -0.3 1.1e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7103648 0.553 rs12803857 chr11:47890172 G/A cg20307385 chr11:47447363 PSMC3 0.67 14.35 0.49 1.15e-40 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.72 0.76 1.44e-122 Cognitive function; BRCA cis rs9527 0.545 rs35756290 chr10:104585572 G/A cg04362960 chr10:104952993 NT5C2 0.44 8.81 0.33 1.14e-17 Arsenic metabolism; BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.63 10.06 0.37 3.3e-22 Renal function-related traits (BUN); BRCA cis rs2294693 0.891 rs9369256 chr6:40998344 G/C cg14769373 chr6:40998127 UNC5CL -0.38 -7.93 -0.3 1e-14 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg17691542 chr6:26056736 HIST1H1C 0.47 9.55 0.35 2.61e-20 Height; BRCA cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.54 0.32 9.73e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs4642101 0.662 rs9874893 chr3:12833079 C/G cg24848339 chr3:12840334 CAND2 0.5 13.19 0.46 2.64e-35 QRS complex (12-leadsum); BRCA cis rs11608355 0.545 rs9943724 chr12:109902903 G/A cg05360138 chr12:110035743 NA 0.71 13.15 0.46 3.98e-35 Neuroticism; BRCA cis rs3008870 0.755 rs10789219 chr1:67417742 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.65 14.16 0.49 8.38e-40 Lymphocyte percentage of white cells; BRCA cis rs4302748 1.000 rs4302748 chr7:36191699 C/T cg24442661 chr7:36192818 EEPD1 0.51 9.61 0.36 1.68e-20 Platelet count; BRCA cis rs6930083 0.605 rs3829964 chr6:36644498 T/C cg08179530 chr6:36648295 CDKN1A 0.74 17.69 0.57 2.66e-57 Coronary artery disease; BRCA cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg01448562 chr3:133502909 NA -0.41 -9.41 -0.35 9.13e-20 Iron status biomarkers; BRCA cis rs2425143 0.730 rs6060626 chr20:34415073 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.33 -0.31 5.07e-16 Blood protein levels; BRCA cis rs11148252 0.846 rs13431 chr13:52987477 G/C cg00495681 chr13:53174319 NA 0.41 8.73 0.33 2.15e-17 Lewy body disease; BRCA cis rs933688 1.000 rs332529 chr5:90789470 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.85 17.04 0.56 6.18e-54 Smoking behavior; BRCA cis rs6121246 0.559 rs10439608 chr20:30258814 T/C cg13852791 chr20:30311386 BCL2L1 0.95 23.24 0.68 4.65e-87 Mean corpuscular hemoglobin; BRCA cis rs7666738 0.609 rs35214820 chr4:98864692 G/A cg05340658 chr4:99064831 C4orf37 0.56 10.76 0.39 6.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4891159 0.790 rs8087557 chr18:74116848 G/C cg24786174 chr18:74118243 ZNF516 -0.75 -20.02 -0.62 1.36e-69 Longevity; BRCA cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg13736514 chr6:26305472 NA -0.4 -12.7 -0.45 4.06e-33 Educational attainment; BRCA trans rs9951602 0.512 rs12455566 chr18:76655926 A/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.07 0.58 3.01e-59 Obesity-related traits; BRCA cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg01483505 chr11:975446 AP2A2 0.33 9.07 0.34 1.44e-18 Alzheimer's disease (late onset); BRCA cis rs12220238 1.000 rs7076721 chr10:75996682 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.49 7.99 0.3 6.44e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg16339924 chr4:17578868 LAP3 0.66 16.87 0.56 4.19e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10193935 0.901 rs2286701 chr2:42555636 T/C cg27598129 chr2:42591480 NA -0.95 -14.8 -0.51 7.85e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6835098 0.961 rs17322893 chr4:174122556 A/G cg27433088 chr4:174089019 GALNT7 -0.33 -8.14 -0.31 2.11e-15 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg05283184 chr6:79620031 NA 0.41 10.99 0.4 7.36e-26 Intelligence (multi-trait analysis); BRCA cis rs67460515 0.892 rs7647374 chr3:160975576 T/A cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Parkinson's disease; BRCA cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg19077165 chr18:44547161 KATNAL2 0.53 11.76 0.42 4.93e-29 Personality dimensions; BRCA cis rs61931739 0.534 rs10844791 chr12:34211659 C/T cg06521331 chr12:34319734 NA -0.65 -11.92 -0.43 1.01e-29 Morning vs. evening chronotype; BRCA cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg13256891 chr4:100009986 ADH5 0.39 7.98 0.3 6.99e-15 Alcohol dependence; BRCA cis rs7092929 0.941 rs705477 chr10:3582161 A/G cg14308648 chr10:3568949 NA 0.45 8.04 0.3 4.3e-15 Coronary artery calcification; BRCA cis rs6546550 0.935 rs13017134 chr2:70090579 C/G cg02498382 chr2:70120550 SNRNP27 -0.43 -9.39 -0.35 9.99e-20 Prevalent atrial fibrillation; BRCA cis rs7254827 0.955 rs12977269 chr19:17215648 G/T cg19418318 chr19:17219073 MYO9B -0.5 -10.18 -0.37 1.17e-22 Mean platelet volume; BRCA cis rs7408868 1.000 rs7254269 chr19:15277429 A/T cg14696996 chr19:15285081 NOTCH3 -1.01 -14.98 -0.51 1.08e-43 Pulse pressure; BRCA cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg26587870 chr6:27730563 NA -0.41 -8.58 -0.32 6.99e-17 Parkinson's disease; BRCA cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg14349672 chr11:133703707 NA -0.39 -8.77 -0.33 1.58e-17 Childhood ear infection; BRCA cis rs9287719 0.601 rs10084172 chr2:10771228 A/C cg00105475 chr2:10696890 NA 0.46 10.25 0.38 6.48e-23 Prostate cancer; BRCA cis rs473651 0.935 rs558924 chr2:239339511 A/G cg21699342 chr2:239360505 ASB1 0.5 11.52 0.41 5.08e-28 Multiple system atrophy; BRCA cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg24642439 chr20:33292090 TP53INP2 -0.6 -12.98 -0.46 2.39e-34 Coronary artery disease; BRCA cis rs6840360 0.615 rs6858483 chr4:152465509 C/T cg22705602 chr4:152727874 NA -0.32 -7.95 -0.3 8.21e-15 Intelligence (multi-trait analysis); BRCA cis rs11229555 0.645 rs7931394 chr11:58212617 T/A cg15696309 chr11:58395628 NA -0.45 -9.64 -0.36 1.27e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1997103 1.000 rs2331067 chr7:55408232 A/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs5758511 0.680 rs1107553 chr22:42667473 A/G cg00645731 chr22:42541494 CYP2D7P1 0.53 10.31 0.38 3.77e-23 Birth weight; BRCA cis rs6740322 0.895 rs11684601 chr2:43574242 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -12.13 -0.43 1.24e-30 Coronary artery disease; BRCA cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.4 -8.41 -0.32 2.7e-16 Ulcerative colitis; BRCA cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs11764590 0.694 rs7801349 chr7:2085553 T/C cg23422044 chr7:1970798 MAD1L1 -0.45 -9.44 -0.35 6.86e-20 Neuroticism; BRCA cis rs7772486 0.738 rs9485039 chr6:146319387 C/T cg23711669 chr6:146136114 FBXO30 0.72 16.16 0.54 1.62e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs8058578 0.887 rs28421305 chr16:30838128 G/A cg02466173 chr16:30829666 NA -0.51 -11.02 -0.4 5.43e-26 Multiple myeloma; BRCA cis rs758324 0.947 rs6861174 chr5:131156129 A/G cg06307176 chr5:131281290 NA 0.52 10.15 0.37 1.55e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg26384229 chr12:38710491 ALG10B -0.58 -13.43 -0.47 2.03e-36 Morning vs. evening chronotype; BRCA cis rs9463078 0.746 rs9395095 chr6:45273877 C/A cg25276700 chr6:44698697 NA -0.36 -8.14 -0.31 2.01e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6665290 0.835 rs7549465 chr1:227214399 A/C cg10327440 chr1:227177885 CDC42BPA -1.1 -40.33 -0.85 8.61e-178 Myeloid white cell count; BRCA cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg09184832 chr6:79620586 NA -0.4 -7.83 -0.3 2.1e-14 Intelligence (multi-trait analysis); BRCA cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg17063962 chr7:91808500 NA 0.52 12.35 0.44 1.39e-31 Breast cancer; BRCA cis rs589448 0.934 rs554591 chr12:69753847 T/C cg14784868 chr12:69753453 YEATS4 0.79 25.2 0.71 7.93e-98 Cerebrospinal fluid biomarker levels; BRCA trans rs4295623 0.531 rs2898295 chr8:11595969 C/T cg15556689 chr8:8085844 FLJ10661 -0.35 -9.28 -0.34 2.69e-19 Morning vs. evening chronotype; BRCA cis rs57024841 0.562 rs2071006 chr9:139839904 G/T cg00693599 chr9:139836323 FBXW5 -0.46 -11.51 -0.41 5.39e-28 Beta-trace protein levels; BRCA cis rs7647973 1.000 rs11720542 chr3:49357427 A/G cg07636037 chr3:49044803 WDR6 0.7 15.0 0.51 8.93e-44 Menarche (age at onset); BRCA cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg21545522 chr1:205238299 TMCC2 0.4 8.36 0.31 3.9e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs10089 1.000 rs1962291 chr5:127445373 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.7 -16.94 -0.56 1.86e-53 Ileal carcinoids; BRCA cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.12 0.34 9.75e-19 Height; BRCA cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 11.87 0.42 1.69e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs13064411 0.518 rs2399480 chr3:113228599 T/C cg18753928 chr3:113234510 CCDC52 -0.45 -9.68 -0.36 8.97e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs11674184 0.743 rs12470971 chr2:11725241 A/G cg07314298 chr2:11723111 GREB1 0.8 19.82 0.62 1.7e-68 Endometriosis; BRCA cis rs11146838 1 rs11146838 chr10:39149977 A/T cg03665457 chr10:38645376 HSD17B7P2 -0.42 -7.84 -0.3 1.84e-14 Breast cancer; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg08061076 chr7:1943177 MAD1L1 -0.34 -7.84 -0.3 1.93e-14 Bipolar disorder and schizophrenia; BRCA cis rs2274273 0.840 rs11547116 chr14:55738165 T/C cg04306507 chr14:55594613 LGALS3 0.31 8.61 0.32 5.51e-17 Protein biomarker; BRCA cis rs2439831 0.850 rs12440573 chr15:44108997 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.52 9.57 0.35 2.35e-20 Lung cancer in ever smokers; BRCA cis rs652260 0.967 rs569175 chr19:7901160 T/G cg26014689 chr19:7917955 EVI5L -0.52 -11.77 -0.42 4.49e-29 Menarche (age at onset); BRCA cis rs7147624 0.938 rs7151148 chr14:65936665 G/C cg03016385 chr14:66212404 NA -0.55 -8.38 -0.31 3.32e-16 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg21747090 chr2:27597821 SNX17 -0.37 -8.0 -0.3 5.8e-15 Total body bone mineral density; BRCA cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg01579765 chr21:45077557 HSF2BP -0.45 -12.17 -0.43 8.31e-31 Mean corpuscular volume; BRCA cis rs921968 0.565 rs1541777 chr2:219587291 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.94e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs12971120 0.891 rs12605820 chr18:72167802 G/A cg26446133 chr18:72167187 CNDP2 -0.75 -14.34 -0.49 1.23e-40 Refractive error; BRCA cis rs17376456 0.877 rs10065056 chr5:93380123 G/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 8.0 0.3 5.67e-15 Diabetic retinopathy; BRCA cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg11764359 chr7:65958608 NA -0.75 -16.69 -0.55 3.49e-52 Aortic root size; BRCA trans rs75804782 0.521 rs56387296 chr2:239426298 A/G cg01134436 chr17:81009848 B3GNTL1 0.69 8.83 0.33 1.03e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg04944784 chr2:26401820 FAM59B -0.95 -16.58 -0.55 1.26e-51 Gut microbiome composition (summer); BRCA cis rs13108904 0.935 rs4974575 chr4:1252028 A/G cg05665937 chr4:1216051 CTBP1 0.39 8.23 0.31 1.09e-15 Obesity-related traits; BRCA cis rs7819412 0.740 rs7844536 chr8:11034028 A/G cg21775007 chr8:11205619 TDH -0.43 -8.88 -0.33 6.77e-18 Triglycerides; BRCA trans rs111612372 1 rs111612372 chr2:20433218 T/C cg27368651 chr22:31829985 DRG1 -0.38 -9.01 -0.34 2.39e-18 Body mass index; BRCA cis rs12618769 0.597 rs3769741 chr2:99068204 G/T cg10123293 chr2:99228465 UNC50 0.4 8.12 0.31 2.46e-15 Bipolar disorder; BRCA cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.03 0.3 4.73e-15 Breast cancer; BRCA cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg10523679 chr1:76189770 ACADM 0.76 15.68 0.53 4.21e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7572733 0.555 rs6434953 chr2:198929693 A/G cg00792783 chr2:198669748 PLCL1 0.39 8.38 0.31 3.32e-16 Dermatomyositis; BRCA cis rs2806561 0.514 rs7519093 chr1:23541078 A/T cg24466277 chr1:23519622 HTR1D 0.39 8.74 0.33 2.08e-17 Height; BRCA cis rs9611565 0.649 rs126092 chr22:42178441 A/G cg03806693 chr22:41940476 POLR3H 0.74 13.84 0.48 2.88e-38 Vitiligo; BRCA cis rs9470366 0.545 rs6930083 chr6:36634156 A/G cg08179530 chr6:36648295 CDKN1A -0.51 -11.31 -0.41 3.77e-27 QRS duration; BRCA cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg04455712 chr21:45112962 RRP1B 0.46 11.72 0.42 6.9e-29 Mean corpuscular volume; BRCA cis rs877282 1.000 rs11253369 chr10:773610 C/G cg17470449 chr10:769945 NA 0.43 8.27 0.31 7.55e-16 Uric acid levels; BRCA cis rs9324022 0.929 rs17099617 chr14:101170488 A/G cg18089426 chr14:101175970 NA 0.64 12.56 0.45 1.65e-32 Plateletcrit; BRCA cis rs501916 0.605 rs8031169 chr15:48080330 G/C cg16110827 chr15:48056943 SEMA6D -0.39 -8.27 -0.31 7.67e-16 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs1451375 0.698 rs11238214 chr7:50636018 A/G cg18232548 chr7:50535776 DDC 0.4 9.29 0.34 2.47e-19 Malaria; BRCA cis rs12478296 0.792 rs57482298 chr2:243011148 C/A cg18898632 chr2:242989856 NA -0.53 -8.84 -0.33 9.49e-18 Obesity-related traits; BRCA cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg03146154 chr1:46216737 IPP 0.54 12.03 0.43 3.34e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.15 0.37 1.57e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg06598544 chr20:61472147 COL9A3 -0.76 -10.64 -0.39 1.87e-24 Obesity-related traits; BRCA cis rs924607 0.898 rs1697990 chr5:626278 A/G cg04476341 chr5:669733 TPPP -0.38 -10.56 -0.39 3.77e-24 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.02 0.3 4.93e-15 Corneal astigmatism; BRCA cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs4588572 0.644 rs11742212 chr5:77779033 G/A cg11547950 chr5:77652471 NA -0.44 -8.45 -0.32 1.95e-16 Triglycerides; BRCA cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.87 0.51 3.82e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg04455712 chr21:45112962 RRP1B 0.44 12.15 0.43 1.07e-30 Mean corpuscular volume; BRCA cis rs1997103 0.954 rs2177809 chr7:55378125 T/C cg17469321 chr7:55412551 NA 0.51 9.66 0.36 1.06e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1215050 0.669 rs783962 chr4:98884473 G/A cg05340658 chr4:99064831 C4orf37 -0.41 -9.18 -0.34 6.12e-19 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1113500 0.933 rs61797345 chr1:108623728 G/A cg06207961 chr1:108661230 NA 0.45 11.11 0.4 2.48e-26 Growth-regulated protein alpha levels; BRCA cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg23711669 chr6:146136114 FBXO30 -0.82 -20.11 -0.62 4.6e-70 Lobe attachment (rater-scored or self-reported); BRCA cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4481887 0.861 rs4497248 chr1:248450525 T/C cg00666640 chr1:248458726 OR2T12 0.31 8.02 0.3 4.91e-15 Common traits (Other); BRCA cis rs1865760 0.566 rs9379821 chr6:26054268 A/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.54 0.42 3.94e-28 Height; BRCA cis rs7851660 0.967 rs6478437 chr9:100607497 A/G cg13688889 chr9:100608707 NA -0.35 -8.56 -0.32 8.52e-17 Strep throat; BRCA cis rs6598955 0.671 rs12142535 chr1:26589698 T/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg24692254 chr21:30365293 RNF160 -0.63 -16.57 -0.55 1.49e-51 Dental caries; BRCA cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4308124 0.708 rs67816163 chr2:111963310 A/G cg04571233 chr2:111982156 NA -0.45 -9.69 -0.36 8.37e-21 Vitiligo; BRCA cis rs2625529 0.652 rs2899776 chr15:72268365 A/T cg16672083 chr15:72433130 SENP8 0.68 16.28 0.54 4.22e-50 Red blood cell count; BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg25036284 chr2:26402008 FAM59B -0.64 -10.61 -0.39 2.5e-24 Gut microbiome composition (summer); BRCA cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 9.09 0.34 1.22e-18 Personality dimensions; BRCA trans rs56176327 0.532 rs9849038 chr3:49771990 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.8 -0.33 1.32e-17 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.875 rs12524077 chr6:145866333 G/C cg23711669 chr6:146136114 FBXO30 0.63 14.68 0.5 2.85e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs28830936 1.000 rs11629678 chr15:41932530 G/A cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.2 -0.34 4.83e-19 Diastolic blood pressure; BRCA cis rs7666738 0.791 rs2081621 chr4:98926753 C/A cg05340658 chr4:99064831 C4orf37 0.67 16.82 0.55 7.42e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs113835537 0.529 rs11227512 chr11:66281291 T/C cg24851651 chr11:66362959 CCS 0.44 8.29 0.31 6.92e-16 Airway imaging phenotypes; BRCA cis rs16976116 0.901 rs113679855 chr15:55502428 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.57 0.39 3.56e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA trans rs9951602 0.512 rs6506874 chr18:76653467 G/T cg02800362 chr5:177631904 HNRNPAB 0.77 18.23 0.58 4.25e-60 Obesity-related traits; BRCA cis rs17095355 1.000 rs17126883 chr10:111694696 A/G cg00817464 chr10:111662876 XPNPEP1 -0.4 -9.08 -0.34 1.35e-18 Biliary atresia; BRCA cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.26 0.38 5.81e-23 Bipolar disorder; BRCA cis rs17854409 0.881 rs6011430 chr20:61497014 C/T cg06598544 chr20:61472147 COL9A3 0.66 9.54 0.35 2.95e-20 Obesity-related traits; BRCA cis rs7561273 0.561 rs35268318 chr2:24352824 A/T cg04809136 chr2:24300158 SF3B14 -0.4 -8.94 -0.33 4.13e-18 Quantitative traits; BRCA cis rs6565180 1.000 rs12930787 chr16:30381303 C/G cg17640201 chr16:30407289 ZNF48 -0.72 -16.6 -0.55 1.07e-51 Tonsillectomy; BRCA cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg08997352 chr12:9597637 DDX12 -0.5 -9.84 -0.36 2.24e-21 Breast size; BRCA cis rs11098499 0.954 rs13145352 chr4:120409963 C/T cg09307838 chr4:120376055 NA -0.77 -16.63 -0.55 6.84e-52 Corneal astigmatism; BRCA cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg21017887 chr14:105400489 NA 0.66 17.47 0.57 3.64e-56 Rheumatoid arthritis; BRCA cis rs6684514 0.961 rs12029695 chr1:156299847 C/T cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.58 0.32 7.41e-17 Diabetic retinopathy; BRCA cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg05623727 chr3:50126028 RBM5 -0.42 -10.2 -0.37 1.02e-22 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg17063962 chr7:91808500 NA 0.56 12.95 0.46 3.21e-34 Breast cancer; BRCA cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg24642439 chr20:33292090 TP53INP2 -0.54 -11.66 -0.42 1.31e-28 Glomerular filtration rate (creatinine); BRCA cis rs7572733 0.514 rs770659 chr2:198669754 G/C cg00792783 chr2:198669748 PLCL1 0.47 10.27 0.38 5.27e-23 Dermatomyositis; BRCA cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg05340658 chr4:99064831 C4orf37 0.59 12.38 0.44 1.07e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg00166722 chr3:10149974 C3orf24 0.65 12.8 0.45 1.54e-33 Alzheimer's disease; BRCA cis rs965469 0.817 rs16988490 chr20:3335431 C/T cg25506879 chr20:3388711 C20orf194 0.46 8.91 0.33 5.25e-18 IFN-related cytopenia; BRCA cis rs11030122 0.702 rs12223176 chr11:3982537 T/G cg18678763 chr11:4115507 RRM1 -0.35 -7.87 -0.3 1.53e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg15556689 chr8:8085844 FLJ10661 0.49 13.87 0.48 2.09e-38 Mood instability; BRCA cis rs10751667 0.666 rs10902248 chr11:957742 A/G cg01483505 chr11:975446 AP2A2 0.33 9.01 0.34 2.38e-18 Alzheimer's disease (late onset); BRCA cis rs897984 0.609 rs57576577 chr16:31036367 G/A cg00531865 chr16:30841666 NA -0.41 -10.08 -0.37 2.92e-22 Dementia with Lewy bodies; BRCA cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg10253484 chr15:75165896 SCAMP2 -0.55 -11.3 -0.41 4.2e-27 Breast cancer; BRCA cis rs3106136 0.527 rs2883 chr4:95158610 A/T cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.14 -0.37 1.7e-22 Capecitabine sensitivity; BRCA cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg08000102 chr2:233561755 GIGYF2 -0.62 -13.46 -0.47 1.55e-36 Coronary artery disease; BRCA cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.05 0.37 3.54e-22 Electroencephalogram traits; BRCA cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -7.87 -0.3 1.53e-14 Personality dimensions; BRCA cis rs11719291 0.915 rs11557629 chr3:48732223 G/A cg07636037 chr3:49044803 WDR6 -0.6 -8.74 -0.33 2.01e-17 Cognitive function; BRCA cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg18230493 chr5:56204884 C5orf35 0.58 12.17 0.43 8.57e-31 Initial pursuit acceleration; BRCA cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.02 0.3 5.01e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.34 -7.86 -0.3 1.66e-14 High light scatter reticulocyte count; BRCA cis rs3820928 0.874 rs10210963 chr2:227821845 A/G cg11843606 chr2:227700838 RHBDD1 -0.39 -8.66 -0.32 3.71e-17 Pulmonary function; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg03188948 chr7:1209495 NA 0.86 11.78 0.42 3.91e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4363385 0.818 rs3806222 chr1:153002606 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.83e-16 Inflammatory skin disease; BRCA cis rs801193 0.742 rs9969300 chr7:65781646 G/A cg18876405 chr7:65276391 NA -0.58 -14.46 -0.5 3.27e-41 Aortic root size; BRCA cis rs7917772 0.503 rs7093285 chr10:104374815 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.08 0.58 2.69e-59 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.78 0.33 1.53e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35995292 0.500 rs7776996 chr7:38919762 G/C cg19327137 chr7:38886074 VPS41 0.38 12.68 0.45 4.91e-33 Subjective well-being (multi-trait analysis); BRCA cis rs1003719 0.612 rs2835652 chr21:38557408 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs9815354 0.812 rs73071328 chr3:41810055 A/C cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA trans rs853679 0.882 rs9468287 chr6:28079741 G/T cg01620082 chr3:125678407 NA -0.58 -8.22 -0.31 1.11e-15 Depression; BRCA cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.55 13.6 0.47 3.45e-37 Colorectal cancer; BRCA cis rs11098499 0.954 rs13151285 chr4:120314741 C/A cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs908922 0.676 rs486283 chr1:152525957 A/G cg20991723 chr1:152506922 NA 0.37 8.29 0.31 6.61e-16 Hair morphology; BRCA cis rs12493885 0.769 rs11718319 chr3:153776944 G/A cg17054900 chr3:154042577 DHX36 -0.5 -8.64 -0.32 4.44e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs61931739 0.534 rs7138522 chr12:34039762 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.28 0.49 2.34e-40 Morning vs. evening chronotype; BRCA cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg12373951 chr3:133503437 NA 0.45 10.48 0.38 8.02e-24 Iron status biomarkers; BRCA cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg21132104 chr15:45694354 SPATA5L1 0.75 16.99 0.56 1.07e-53 Homoarginine levels; BRCA cis rs7474896 0.583 rs1208770 chr10:38044683 C/T cg25427524 chr10:38739819 LOC399744 -0.54 -9.73 -0.36 6.02e-21 Obesity (extreme); BRCA cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg21573476 chr21:45109991 RRP1B -0.4 -10.6 -0.39 2.81e-24 Mean corpuscular volume; BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26314531 chr2:26401878 FAM59B -0.63 -10.93 -0.4 1.27e-25 Gut microbiome composition (summer); BRCA cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.64 -16.35 -0.54 1.94e-50 Colorectal cancer; BRCA cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg26850624 chr5:429559 AHRR -0.34 -8.29 -0.31 6.85e-16 Cystic fibrosis severity; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs11718455 1.000 rs4682928 chr3:44037192 T/C cg08738300 chr3:44038990 NA 0.47 9.0 0.34 2.63e-18 Coronary artery disease; BRCA cis rs10411936 0.720 rs2885706 chr19:16582937 C/A cg10248733 chr19:16607483 C19orf44;CALR3 0.46 9.65 0.36 1.19e-20 White blood cell count;Multiple sclerosis; BRCA cis rs6061231 0.837 rs6061235 chr20:60978524 C/G cg22601191 chr20:60968625 CABLES2 0.42 9.74 0.36 5.35e-21 Colorectal cancer; BRCA cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg14196790 chr5:131705035 SLC22A5 0.42 10.05 0.37 3.72e-22 Breast cancer;Mosquito bite size; BRCA cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg20701182 chr2:24300061 SF3B14 0.67 9.77 0.36 4.1e-21 Lymphocyte counts; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg23708337 chr7:1209742 NA 0.64 8.93 0.33 4.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2816062 0.786 rs2816055 chr1:18898248 A/G cg18795169 chr1:18902165 NA -0.98 -29.37 -0.76 1.19e-120 Urate levels in lean individuals; BRCA cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg07606381 chr6:8435919 SLC35B3 -0.92 -18.13 -0.58 1.39e-59 Motion sickness; BRCA trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -11.32 -0.41 3.19e-27 Neuroticism; BRCA trans rs208515 0.525 rs10944863 chr6:66676238 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 14.54 0.5 1.32e-41 Exhaled nitric oxide levels; BRCA cis rs9650657 0.504 rs10109167 chr8:11033525 C/T cg21775007 chr8:11205619 TDH -0.44 -9.32 -0.35 1.84e-19 Neuroticism; BRCA cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.03 0.37 4.22e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9462027 0.628 rs9469887 chr6:34758940 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.33e-15 Systemic lupus erythematosus; BRCA cis rs9814567 1.000 rs4974483 chr3:134219001 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.31 -0.35 2.07e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg11266682 chr4:10021025 SLC2A9 0.48 12.56 0.44 1.71e-32 Bone mineral density; BRCA cis rs1865760 0.566 rs2794720 chr6:26087202 G/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs2304069 0.826 rs2244195 chr5:149403528 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.7 15.23 0.52 6.47e-45 HIV-1 control; BRCA cis rs739401 0.527 rs423236 chr11:3065916 C/T cg25174290 chr11:3078921 CARS 0.45 13.71 0.48 1.08e-37 Longevity; BRCA trans rs6582630 0.519 rs4406888 chr12:38293312 A/C cg06521331 chr12:34319734 NA -0.47 -8.77 -0.33 1.59e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs11585357 0.947 rs11585118 chr1:17605774 C/A cg19159961 chr1:17633534 PADI4 0.57 8.9 0.33 5.53e-18 Hair shape; BRCA cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Depression; BRCA cis rs4713118 0.786 rs200502 chr6:27788062 C/T cg20933634 chr6:27740509 NA 0.44 8.34 0.31 4.63e-16 Parkinson's disease; BRCA trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg23505145 chr19:12996616 KLF1 0.54 12.39 0.44 9.54e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg20891558 chr2:74357851 NA 0.53 12.34 0.44 1.61e-31 Gestational age at birth (maternal effect); BRCA cis rs250677 0.652 rs168751 chr5:148438264 C/T cg12140854 chr5:148520817 ABLIM3 -0.45 -9.39 -0.35 1.07e-19 Breast cancer; BRCA cis rs78761021 0.720 rs874174 chr17:9798619 C/T cg26853458 chr17:9805074 RCVRN -0.44 -8.88 -0.33 6.52e-18 Type 2 diabetes; BRCA cis rs6942756 0.876 rs1559486 chr7:129015894 C/T cg02491457 chr7:128862824 NA -0.6 -12.43 -0.44 6.14e-32 White matter hyperintensity burden; BRCA cis rs9443645 0.810 rs9361482 chr6:79750385 T/C cg11833968 chr6:79620685 NA -0.42 -9.37 -0.35 1.24e-19 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11890956 chr21:40555474 PSMG1 -0.61 -13.71 -0.48 1.1e-37 Menarche (age at onset); BRCA cis rs16976116 0.851 rs28393427 chr15:55490981 A/G cg11288833 chr15:55489084 RSL24D1 0.47 10.61 0.39 2.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg11833968 chr6:79620685 NA -0.43 -9.58 -0.35 2.18e-20 Intelligence (multi-trait analysis); BRCA cis rs66573146 0.572 rs66819208 chr4:6946128 A/G cg00086871 chr4:6988644 TBC1D14 0.77 11.86 0.42 1.9e-29 Granulocyte percentage of myeloid white cells; BRCA cis rs6028335 0.674 rs66647661 chr20:37671577 C/T cg16355469 chr20:37678765 NA 0.51 9.08 0.34 1.37e-18 Alcohol and nicotine co-dependence; BRCA cis rs7945705 0.935 rs2653593 chr11:8877317 G/A cg12365402 chr11:9010492 NRIP3 -0.37 -8.44 -0.32 2.14e-16 Hemoglobin concentration; BRCA cis rs17685 0.712 rs10235738 chr7:75773460 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 5.04e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10751667 0.666 rs10902255 chr11:967268 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.51 0.55 2.86e-51 Alzheimer's disease (late onset); BRCA cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg17372223 chr3:52568218 NT5DC2 0.34 7.91 0.3 1.11e-14 Electroencephalogram traits; BRCA cis rs9868809 0.505 rs13434258 chr3:48738491 T/C cg00383909 chr3:49044727 WDR6 0.6 10.99 0.4 7.27e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7249921 0.833 rs1046294 chr19:35660546 T/C cg15419183 chr19:35660584 FXYD5 0.45 10.15 0.37 1.46e-22 Platelet count; BRCA cis rs3733585 0.699 rs4473653 chr4:9971058 A/G cg11266682 chr4:10021025 SLC2A9 -0.37 -9.64 -0.36 1.26e-20 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9868809 0.505 rs56735597 chr3:48765168 A/G cg03060546 chr3:49711283 APEH -0.57 -7.88 -0.3 1.41e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs4766646 0.619 rs4766639 chr12:110298925 A/G cg01252219 chr12:110302105 GLTP 0.36 8.11 0.31 2.6e-15 Metabolite levels (MHPG); BRCA cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.46 9.98 0.37 6.74e-22 Cognitive ability; BRCA cis rs2991971 0.782 rs10789463 chr1:45927848 C/A cg24296786 chr1:45957014 TESK2 -0.52 -12.02 -0.43 3.96e-30 High light scatter reticulocyte count; BRCA cis rs17401966 1.000 rs17411502 chr1:10431158 T/C cg03954927 chr1:10346856 KIF1B 0.44 12.42 0.44 7.37e-32 Hepatocellular carcinoma; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg23708337 chr7:1209742 NA 0.64 8.74 0.33 2.05e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg00530320 chr1:46809349 NSUN4 -0.47 -9.6 -0.35 1.84e-20 Menopause (age at onset); BRCA cis rs7520050 0.966 rs1085244 chr1:46563680 C/A cg24296786 chr1:45957014 TESK2 0.43 9.71 0.36 6.81e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7572733 0.534 rs10211202 chr2:198771941 A/G cg00792783 chr2:198669748 PLCL1 0.48 10.36 0.38 2.27e-23 Dermatomyositis; BRCA cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg08807101 chr21:30365312 RNF160 0.4 8.53 0.32 1.08e-16 Pancreatic cancer; BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.6 -0.32 5.96e-17 Total body bone mineral density; BRCA cis rs9427116 0.502 rs9427100 chr1:154583762 G/A cg17218026 chr1:154582156 ADAR 0.28 8.36 0.31 4.03e-16 Blood protein levels; BRCA trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg15704280 chr7:45808275 SEPT13 0.65 11.44 0.41 1.06e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg09877947 chr5:131593287 PDLIM4 0.36 7.81 0.3 2.32e-14 Breast cancer; BRCA cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Smoking initiation; BRCA cis rs1113500 0.897 rs55980437 chr1:108639498 G/A cg06207961 chr1:108661230 NA 0.45 10.95 0.4 1.11e-25 Growth-regulated protein alpha levels; BRCA cis rs7975161 0.938 rs10400561 chr12:104640920 A/G cg25273343 chr12:104657179 TXNRD1 -0.54 -11.36 -0.41 2.25e-27 Toenail selenium levels; BRCA cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg08917208 chr2:24149416 ATAD2B 0.87 12.44 0.44 5.65e-32 Lymphocyte counts; BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.17 0.31 1.61e-15 Tonsillectomy; BRCA cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.68 -14.17 -0.49 8.17e-40 Chronic sinus infection; BRCA cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg11890956 chr21:40555474 PSMG1 1.05 30.23 0.77 2.39e-125 Cognitive function; BRCA cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg20573242 chr4:122745356 CCNA2 0.46 10.24 0.38 7.15e-23 Type 2 diabetes; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg04013093 chr6:42928303 GNMT 0.28 8.9 0.33 5.53e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9790314 0.905 rs7632797 chr3:161002694 C/T cg03342759 chr3:160939853 NMD3 0.65 14.31 0.49 1.73e-40 Morning vs. evening chronotype; BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg21747090 chr2:27597821 SNX17 -0.41 -8.86 -0.33 7.64e-18 Total body bone mineral density; BRCA cis rs9467773 1.000 rs10214634 chr6:26564582 T/A cg09904177 chr6:26538194 HMGN4 0.55 17.62 0.57 6.29e-57 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg21918786 chr6:109611834 NA -0.34 -9.12 -0.34 9.73e-19 Reticulocyte fraction of red cells; BRCA cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg22467129 chr15:76604101 ETFA -0.48 -10.68 -0.39 1.28e-24 Blood metabolite levels; BRCA cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg03146154 chr1:46216737 IPP -0.51 -11.29 -0.41 4.29e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 1.000 rs11211239 chr1:46451947 A/G cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -14.01 -0.48 4.52e-39 Extrinsic epigenetic age acceleration; BRCA cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg04117972 chr1:227635322 NA 0.49 8.91 0.33 5.22e-18 Major depressive disorder; BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg23285459 chr7:2802560 GNA12 -0.34 -8.67 -0.32 3.57e-17 Height; BRCA cis rs700651 0.821 rs771005 chr2:198675948 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.22 0.37 8.54e-23 Intracranial aneurysm; BRCA cis rs201673768 1 rs201673768 chr12:48699606 TGTTTTGTTTTG/T cg24011408 chr12:48396354 COL2A1 0.43 8.65 0.32 4.24e-17 Platelet count; BRCA cis rs4237845 0.611 rs7298370 chr12:58318897 C/T cg02175503 chr12:58329896 NA 0.77 18.75 0.6 7.52e-63 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.720 rs1611754 chr1:152956415 A/T cg21543102 chr1:152974771 SPRR3 -0.3 -8.65 -0.32 4.25e-17 Inflammatory skin disease; BRCA cis rs7756236 0.521 rs6930671 chr6:36625272 T/C cg08179530 chr6:36648295 CDKN1A 0.38 8.19 0.31 1.47e-15 QRS duration; BRCA cis rs6580649 0.941 rs72644847 chr12:48516093 C/A cg05342945 chr12:48394962 COL2A1 0.44 8.34 0.31 4.73e-16 Lung cancer; BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg17158414 chr2:27665306 KRTCAP3 -0.35 -8.77 -0.33 1.64e-17 Total body bone mineral density; BRCA cis rs9486719 1.000 rs67996804 chr6:96884387 C/T cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.7200000000000002e-34 Migraine;Coronary artery disease; BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg04518342 chr5:131593106 PDLIM4 0.35 8.99 0.34 2.75e-18 Breast cancer; BRCA cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg25208724 chr1:156163844 SLC25A44 1.07 35.1 0.81 3.35e-151 Testicular germ cell tumor; BRCA cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs7975161 0.882 rs4406890 chr12:104638773 A/C cg25273343 chr12:104657179 TXNRD1 -0.49 -10.83 -0.39 3.23e-25 Toenail selenium levels; BRCA cis rs11105298 0.891 rs12228177 chr12:89862030 G/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.94 -0.37 9.36e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs875971 0.862 rs2024192 chr7:66041447 G/T cg18876405 chr7:65276391 NA -0.5 -11.04 -0.4 4.59e-26 Aortic root size; BRCA cis rs7833986 0.501 rs17814658 chr8:56989130 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.18 0.46 3.04e-35 Height; BRCA cis rs7188861 0.768 rs12922733 chr16:11380670 C/G cg01510278 chr16:11456238 NA 0.42 8.27 0.31 7.61e-16 HDL cholesterol; BRCA trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg15556689 chr8:8085844 FLJ10661 0.41 10.11 0.37 2.15e-22 Retinal vascular caliber; BRCA cis rs12431939 1.000 rs7160729 chr14:51637241 C/T cg23942311 chr14:51606299 NA -0.42 -8.2 -0.31 1.27e-15 Cancer; BRCA cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg00031303 chr3:195681400 NA 0.72 12.11 0.43 1.57e-30 Pancreatic cancer; BRCA cis rs11718455 0.883 rs6795366 chr3:44005735 C/T cg08738300 chr3:44038990 NA 0.42 8.25 0.31 9.2e-16 Coronary artery disease; BRCA cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg10978503 chr1:24200527 CNR2 0.48 12.76 0.45 2.31e-33 Immature fraction of reticulocytes; BRCA cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.24 0.34 3.68e-19 Systemic lupus erythematosus; BRCA cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg04455712 chr21:45112962 RRP1B 0.38 9.8 0.36 3.13e-21 Mean corpuscular volume; BRCA cis rs7927592 0.956 rs60212556 chr11:68305494 C/T cg20283391 chr11:68216788 NA -0.42 -8.28 -0.31 7.03e-16 Total body bone mineral density; BRCA cis rs4595586 0.545 rs12815047 chr12:39380901 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.46 0.35 5.57e-20 Parkinson's disease; BRCA cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg17366294 chr4:99064904 C4orf37 0.46 10.78 0.39 5.16e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs7939886 0.841 rs11231800 chr11:55770930 A/G cg15704280 chr7:45808275 SEPT13 0.72 8.55 0.32 8.79e-17 Myopia (pathological); BRCA trans rs2204008 0.806 rs7305409 chr12:38349133 G/A cg06521331 chr12:34319734 NA -0.52 -9.3 -0.35 2.25e-19 Bladder cancer; BRCA trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21582582 chr3:182698605 DCUN1D1 0.37 9.86 0.36 1.95e-21 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg25214090 chr10:38739885 LOC399744 0.54 12.24 0.44 4.48e-31 Corneal astigmatism; BRCA cis rs738321 0.757 rs6001020 chr22:38538246 C/G cg20207973 chr22:38506712 BAIAP2L2 0.43 10.23 0.38 7.42e-23 Breast cancer; BRCA cis rs1878931 0.696 rs35984213 chr16:3451030 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.02 28.55 0.75 3.43e-116 Body mass index (adult); BRCA trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg27661571 chr11:113659931 NA -0.49 -8.68 -0.32 3.31e-17 Hip circumference adjusted for BMI; BRCA cis rs3936840 0.752 rs2181343 chr14:102993303 A/C cg18135206 chr14:102964638 TECPR2 -0.52 -11.16 -0.4 1.54e-26 Plateletcrit; BRCA cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg22535103 chr8:58192502 C8orf71 -0.6 -13.25 -0.46 1.4e-35 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg22467129 chr15:76604101 ETFA -0.49 -10.63 -0.39 2.11e-24 Blood metabolite levels; BRCA cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg05623727 chr3:50126028 RBM5 0.49 11.79 0.42 3.54e-29 Body mass index; BRCA cis rs10751667 0.666 rs7483273 chr11:951127 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.38 0.54 1.32e-50 Alzheimer's disease (late onset); BRCA cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg11812906 chr14:75593930 NEK9 -0.7 -16.24 -0.54 6.29e-50 Height; BRCA cis rs79976124 0.879 rs10944856 chr6:66636960 G/C cg07460842 chr6:66804631 NA 0.61 10.47 0.38 8.69e-24 Type 2 diabetes; BRCA cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg16586182 chr3:47516702 SCAP 0.56 12.87 0.45 7.33e-34 Colorectal cancer; BRCA cis rs2430307 0.556 rs3930019 chr7:76541610 C/T cg05843312 chr7:76586131 NA 0.48 8.32 0.31 5.13e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA trans rs61931739 0.817 rs1705771 chr12:34174950 C/G cg26384229 chr12:38710491 ALG10B 0.42 10.01 0.37 5.35e-22 Morning vs. evening chronotype; BRCA cis rs858239 0.632 rs13438452 chr7:23174182 A/G cg23682824 chr7:23144976 KLHL7 0.44 11.85 0.42 2.01e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs2762353 0.935 rs1165213 chr6:25799676 A/G cg03517284 chr6:25882590 NA 0.48 10.84 0.39 3.09e-25 Blood metabolite levels; BRCA cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg23033748 chr14:75592666 NEK9 0.4 9.79 0.36 3.45e-21 Height; BRCA cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg03060546 chr3:49711283 APEH 0.49 10.39 0.38 1.76e-23 Resting heart rate; BRCA cis rs10193935 0.901 rs6733464 chr2:42563597 A/G cg27598129 chr2:42591480 NA -0.91 -14.73 -0.5 1.78e-42 Colonoscopy-negative controls vs population controls; BRCA trans rs9951602 0.512 rs8085719 chr18:76649111 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 18.06 0.58 3.43e-59 Obesity-related traits; BRCA cis rs911186 0.812 rs35454259 chr6:27254475 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.34 -0.31 4.56e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs4481887 0.927 rs4578248 chr1:248434069 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.23 0.31 1.03e-15 Common traits (Other); BRCA trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA trans rs11098499 0.909 rs28632018 chr4:120386730 T/C cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg04553112 chr3:125709451 NA 0.56 8.5 0.32 1.37e-16 Blood pressure (smoking interaction); BRCA cis rs4853036 0.638 rs55723319 chr2:70118385 C/T cg02498382 chr2:70120550 SNRNP27 -0.59 -8.72 -0.33 2.43e-17 Colorectal or endometrial cancer; BRCA cis rs7523273 0.927 rs1891423 chr1:207931913 G/A cg22525895 chr1:207977042 MIR29B2 0.47 11.2 0.4 1.08e-26 Schizophrenia; BRCA cis rs769267 0.629 rs7245672 chr19:19699963 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.44 -8.43 -0.32 2.29e-16 Tonsillectomy; BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg27170947 chr2:26402098 FAM59B -0.66 -11.39 -0.41 1.75e-27 Gut microbiome composition (summer); BRCA cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg25319279 chr11:5960081 NA -0.4 -8.68 -0.32 3.36e-17 DNA methylation (variation); BRCA cis rs1595825 0.891 rs16825188 chr2:198741134 G/C cg19156104 chr2:198669113 PLCL1 -0.46 -8.25 -0.31 8.76e-16 Ulcerative colitis; BRCA cis rs9287719 0.967 rs2287061 chr2:10743153 C/T cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs6450176 1.000 rs4334836 chr5:53300835 T/C ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.83e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs6987853 0.787 rs2974351 chr8:42407047 A/T cg09913449 chr8:42400586 C8orf40 0.42 9.39 0.35 1.07e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg27286337 chr10:134555280 INPP5A 0.63 11.17 0.4 1.42e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2243480 1.000 rs73150014 chr7:65450919 A/C cg18252515 chr7:66147081 NA -0.89 -12.82 -0.45 1.17e-33 Diabetic kidney disease; BRCA trans rs208515 0.525 rs9453538 chr6:66668508 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 15.96 0.53 1.74e-48 Exhaled nitric oxide levels; BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.6 0.32 6.24e-17 Platelet count; BRCA cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg17971929 chr21:40555470 PSMG1 -0.62 -14.65 -0.5 3.97e-42 Cognitive function; BRCA cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg04450456 chr4:17643702 FAM184B 0.35 9.83 0.36 2.48e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg11833968 chr6:79620685 NA 0.44 10.0 0.37 5.91e-22 Intelligence (multi-trait analysis); BRCA cis rs11227306 0.902 rs625652 chr11:65641931 T/A cg00576331 chr11:65640516 EFEMP2 0.42 9.48 0.35 4.85e-20 DNA methylation (variation); BRCA cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.55 9.15 0.34 7.4e-19 Renal function-related traits (BUN); BRCA cis rs7246657 0.943 rs2126977 chr19:37995747 C/G cg14683738 chr19:37701593 ZNF585B -0.45 -7.97 -0.3 7.48e-15 Coronary artery calcification; BRCA cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg02376097 chr19:46275166 DMPK 0.45 10.08 0.37 2.72e-22 Coronary artery disease; BRCA cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.19e-24 Chronic sinus infection; BRCA cis rs2624839 0.704 rs2526384 chr3:50181136 C/T cg14019146 chr3:50243930 SLC38A3 -0.68 -16.59 -0.55 1.11e-51 Intelligence (multi-trait analysis); BRCA cis rs12618769 0.597 rs3769734 chr2:99096149 A/T cg10123293 chr2:99228465 UNC50 0.42 8.18 0.31 1.53e-15 Bipolar disorder; BRCA cis rs2882667 0.931 rs10044736 chr5:138320809 A/G cg04439458 chr5:138467593 SIL1 0.34 9.38 0.35 1.16e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg19077165 chr18:44547161 KATNAL2 0.42 8.95 0.33 3.85e-18 Educational attainment; BRCA cis rs11608355 0.515 rs3742018 chr12:109949134 C/T cg05360138 chr12:110035743 NA 0.74 13.64 0.47 2.36e-37 Neuroticism; BRCA trans rs9951602 0.512 rs7237214 chr18:76657394 C/G cg02800362 chr5:177631904 HNRNPAB 0.78 17.72 0.57 1.79e-57 Obesity-related traits; BRCA cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg12011299 chr4:100065546 ADH4 0.5 11.72 0.42 7.29e-29 Alcohol dependence; BRCA cis rs9807989 0.507 rs6734762 chr2:103062926 C/T cg03938978 chr2:103052716 IL18RAP 0.28 8.17 0.31 1.62e-15 Asthma; BRCA cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg18876405 chr7:65276391 NA -0.63 -15.47 -0.52 4.35e-46 Aortic root size; BRCA cis rs8114671 0.869 rs1407202 chr20:33651967 C/T cg24642439 chr20:33292090 TP53INP2 -0.43 -8.61 -0.32 5.56e-17 Height; BRCA cis rs36051895 0.664 rs10117565 chr9:5094461 G/A cg02405213 chr9:5042618 JAK2 -0.5 -8.97 -0.33 3.16e-18 Pediatric autoimmune diseases; BRCA cis rs7474896 0.515 rs2505233 chr10:38340265 C/T cg25427524 chr10:38739819 LOC399744 -0.51 -9.68 -0.36 8.7e-21 Obesity (extreme); BRCA cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg13319975 chr6:146136371 FBXO30 0.41 9.29 0.34 2.42e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg18963800 chr10:38644991 HSD17B7P2 -0.42 -8.2 -0.31 1.35e-15 Extrinsic epigenetic age acceleration; BRCA cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg20019365 chr2:219134978 PNKD;AAMP 0.52 11.78 0.42 4.16e-29 Colorectal cancer; BRCA cis rs7618915 0.501 rs7624716 chr3:52751534 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 4.09e-29 Bipolar disorder; BRCA cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg26384229 chr12:38710491 ALG10B -0.57 -13.43 -0.47 2.23e-36 Bladder cancer; BRCA cis rs7715806 0.500 rs58968428 chr5:75004107 A/G cg19683494 chr5:74908142 NA 0.5 8.1 0.31 2.81e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11874712 0.931 rs8095031 chr18:43666861 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs757110 0.740 rs10832776 chr11:17385224 C/A cg04705435 chr11:17411270 KCNJ11 0.42 9.03 0.34 2.06e-18 Type 2 diabetes; BRCA cis rs2505998 0.833 rs1864405 chr10:43604148 A/C cg15436174 chr10:43711423 RASGEF1A -0.43 -8.33 -0.31 4.83e-16 Hirschsprung disease; BRCA cis rs208515 0.525 rs1484577 chr6:66688397 A/G cg07460842 chr6:66804631 NA 0.81 15.13 0.51 2.08e-44 Exhaled nitric oxide levels; BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg08219700 chr8:58056026 NA 0.57 9.56 0.35 2.56e-20 Developmental language disorder (linguistic errors); BRCA cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg11502198 chr6:26597334 ABT1 0.47 9.4 0.35 9.69e-20 Intelligence (multi-trait analysis); BRCA cis rs6450176 1.000 rs6876198 chr5:53303595 A/G ch.5.1024479R chr5:53302184 ARL15 -0.65 -15.91 -0.53 2.82e-48 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs965469 0.762 rs6515783 chr20:3245006 T/C cg25506879 chr20:3388711 C20orf194 -0.43 -8.68 -0.32 3.38e-17 IFN-related cytopenia; BRCA cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg20203395 chr5:56204925 C5orf35 -0.49 -10.06 -0.37 3.27e-22 Initial pursuit acceleration; BRCA cis rs1474256 0.630 rs79015977 chr15:79450147 G/A cg17916960 chr15:79447300 NA 0.38 8.42 0.32 2.43e-16 Bronchopulmonary dysplasia; BRCA cis rs7512552 0.839 rs17596326 chr1:150433819 A/G cg15654264 chr1:150340011 RPRD2 0.4 8.56 0.32 8.26e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs17604090 1.000 rs28591682 chr7:29690811 T/C cg19413766 chr7:29689036 LOC646762 -0.57 -7.83 -0.3 2.1e-14 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA trans rs11098499 0.955 rs35434465 chr4:120169378 C/G cg25214090 chr10:38739885 LOC399744 0.5 11.02 0.4 5.85e-26 Corneal astigmatism; BRCA cis rs4285028 0.948 rs1920290 chr3:121672305 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs965469 1.000 rs6037562 chr20:3326141 A/C cg25506879 chr20:3388711 C20orf194 -0.55 -10.7 -0.39 1.07e-24 IFN-related cytopenia; BRCA cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs10267417 0.603 rs10224041 chr7:19903837 T/C cg05791153 chr7:19748676 TWISTNB 0.47 9.1 0.34 1.13e-18 Night sleep phenotypes; BRCA cis rs2880765 0.835 rs11856869 chr15:86029097 C/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.62 -0.32 5.2e-17 Coronary artery disease; BRCA cis rs9400271 0.632 rs9398192 chr6:109587236 C/T cg01475377 chr6:109611718 NA -0.44 -10.49 -0.38 7.17e-24 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7091068 0.518 rs4144098 chr10:95432600 C/T cg20715218 chr10:95462985 C10orf4 0.48 10.3 0.38 4.04e-23 Urinary tract infection frequency; BRCA cis rs6460942 1.000 rs77494477 chr7:12315302 A/T cg06484146 chr7:12443880 VWDE -0.63 -8.62 -0.32 5.11e-17 Coronary artery disease; BRCA cis rs72781680 0.716 rs2712061 chr2:24026411 G/A cg08917208 chr2:24149416 ATAD2B 0.57 9.46 0.35 5.72e-20 Lymphocyte counts; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg10862848 chr6:42927986 GNMT 0.35 14.93 0.51 1.83e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6582630 0.572 rs7315897 chr12:38449081 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.88 -0.36 1.66e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs6446731 0.593 rs7674472 chr4:3273538 C/G cg08886695 chr4:3369023 RGS12 -0.38 -9.89 -0.36 1.49e-21 Mean platelet volume; BRCA cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg08645402 chr16:4508243 NA 0.45 10.16 0.37 1.41e-22 Schizophrenia; BRCA cis rs11249608 0.636 rs6888539 chr5:178449010 T/A cg21905437 chr5:178450457 ZNF879 0.51 10.7 0.39 1.12e-24 Pubertal anthropometrics; BRCA cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg17892150 chr10:133769511 PPP2R2D -0.73 -15.69 -0.53 3.49e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7523273 0.606 rs2724388 chr1:207933577 T/G cg22525895 chr1:207977042 MIR29B2 0.47 12.07 0.43 2.39e-30 Schizophrenia; BRCA cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg18196295 chr10:418757 DIP2C -0.59 -13.79 -0.48 4.68e-38 Psychosis in Alzheimer's disease; BRCA cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg05040210 chr1:18807594 KLHDC7A -0.56 -13.51 -0.47 9.17e-37 Breast cancer; BRCA cis rs17401966 1.000 rs1536263 chr1:10378914 T/C cg15208524 chr1:10270712 KIF1B 0.37 7.95 0.3 8.69e-15 Hepatocellular carcinoma; BRCA cis rs769267 0.629 rs7245672 chr19:19699963 T/C cg03709012 chr19:19516395 GATAD2A -0.46 -9.03 -0.34 2e-18 Tonsillectomy; BRCA cis rs4595586 0.545 rs1156707 chr12:39372451 G/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs9467773 0.620 rs2451744 chr6:26633463 G/T cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.68e-30 Intelligence (multi-trait analysis); BRCA trans rs3749237 0.964 rs10865959 chr3:49891002 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.33 8.17 0.31 1.62e-15 Resting heart rate; BRCA cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg23711669 chr6:146136114 FBXO30 0.74 17.75 0.57 1.27e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs6867032 1.000 rs16902321 chr5:2015148 A/G cg26168224 chr5:2018326 NA 0.63 18.24 0.59 3.85e-60 Gut microbiome composition (winter); BRCA cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -11.11 -0.4 2.4e-26 Glomerular filtration rate (creatinine); BRCA cis rs344364 0.511 rs1657144 chr16:1963989 C/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.57 -9.59 -0.35 1.91e-20 Glomerular filtration rate in chronic kidney disease; BRCA cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs11608355 0.545 rs11615336 chr12:109914802 C/A cg05360138 chr12:110035743 NA 0.71 13.05 0.46 1.09e-34 Neuroticism; BRCA cis rs2243480 0.901 rs3813708 chr7:65305632 C/A cg18252515 chr7:66147081 NA -0.88 -12.21 -0.43 5.75e-31 Diabetic kidney disease; BRCA cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.67e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6835098 1.000 rs6814857 chr4:174082805 T/A cg08422745 chr4:174089978 GALNT7 -0.79 -16.5 -0.55 3.13e-51 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.12 0.31 2.41e-15 Cardiac Troponin-T levels; BRCA cis rs250677 1.000 rs36079 chr5:148430504 G/A cg12140854 chr5:148520817 ABLIM3 -0.4 -8.52 -0.32 1.18e-16 Breast cancer; BRCA cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.66 10.4 0.38 1.6e-23 Schizophrenia; BRCA cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg06640241 chr16:89574553 SPG7 0.84 21.15 0.64 1.14e-75 Multiple myeloma (IgH translocation); BRCA cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg26408565 chr15:76604113 ETFA -0.49 -10.41 -0.38 1.45e-23 Blood metabolite levels; BRCA cis rs950776 0.752 rs7182583 chr15:78899210 G/C cg06917634 chr15:78832804 PSMA4 0.58 11.74 0.42 5.77e-29 Sudden cardiac arrest; BRCA cis rs12618769 0.543 rs58778964 chr2:99110599 G/C cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA trans rs7615952 0.546 rs2976733 chr3:125414138 T/C cg07211511 chr3:129823064 LOC729375 -0.57 -10.48 -0.38 8.33e-24 Blood pressure (smoking interaction); BRCA cis rs16910800 0.689 rs7128636 chr11:23164689 C/T cg20040320 chr11:23191996 NA -0.56 -9.28 -0.34 2.49e-19 Cancer; BRCA cis rs1994135 0.617 rs10844642 chr12:33730368 A/C cg06521331 chr12:34319734 NA -0.5 -9.31 -0.35 1.94e-19 Resting heart rate; BRCA cis rs312274 0.515 rs1928558 chr12:41253042 T/C cg17827154 chr12:41323612 CNTN1 -0.41 -10.02 -0.37 4.83e-22 Metabolite levels (X-11787); BRCA cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg13256891 chr4:100009986 ADH5 0.49 10.3 0.38 3.9699999999999997e-23 Alcohol dependence; BRCA cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg24812749 chr6:127587940 RNF146 0.62 13.6 0.47 3.34e-37 Breast cancer; BRCA cis rs4285028 0.747 rs9850439 chr3:121393075 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.85 -0.48 2.53e-38 Multiple sclerosis; BRCA cis rs736408 0.812 rs2071507 chr3:52826707 G/A cg18404041 chr3:52824283 ITIH1 -0.52 -15.36 -0.52 1.46e-45 Bipolar disorder; BRCA trans rs208520 0.955 rs9453664 chr6:66976079 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 11.68 0.42 1.01e-28 Exhaled nitric oxide output; BRCA cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.26e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg18016565 chr1:150552671 MCL1 0.34 8.04 0.3 4.38e-15 Tonsillectomy; BRCA cis rs2762353 0.935 rs1892249 chr6:25768992 A/G cg03264133 chr6:25882463 NA 0.49 10.96 0.4 1.01e-25 Blood metabolite levels; BRCA cis rs10782582 0.609 rs10873797 chr1:76377191 G/T cg03433033 chr1:76189801 ACADM -0.39 -7.96 -0.3 8.16e-15 Daytime sleep phenotypes; BRCA cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg12432903 chr7:1882776 MAD1L1 0.45 8.07 0.3 3.4e-15 Bipolar disorder; BRCA cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg12386194 chr3:101231763 SENP7 0.46 9.67 0.36 9.52e-21 Colorectal cancer; BRCA cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg22676075 chr6:135203613 NA 0.44 8.54 0.32 9.62e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs6714710 0.535 rs13033383 chr2:98339513 C/T cg26665480 chr2:98280029 ACTR1B 0.62 13.78 0.48 5.07e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs897080 0.515 rs698767 chr2:44576417 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.62 11.82 0.42 2.77e-29 Height; BRCA trans rs11098499 0.754 rs28643450 chr4:120245242 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.29 0.38 4.57e-23 Corneal astigmatism; BRCA cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg05665937 chr4:1216051 CTBP1 0.43 8.62 0.32 5.41e-17 Obesity-related traits; BRCA cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg22974920 chr21:40686053 BRWD1 -0.38 -8.76 -0.33 1.73e-17 Cognitive function; BRCA cis rs4268898 0.931 rs55642516 chr2:24502305 A/G cg06627628 chr2:24431161 ITSN2 -0.52 -10.38 -0.38 1.9e-23 Asthma; BRCA cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.36e-31 Bipolar disorder; BRCA cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg11764359 chr7:65958608 NA 0.67 14.96 0.51 1.27e-43 Aortic root size; BRCA cis rs769267 0.965 rs13964 chr19:19468710 C/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.46 -0.35 5.8e-20 Tonsillectomy; BRCA cis rs9308433 0.529 rs9430133 chr1:214496313 C/T cg06198575 chr1:214491504 SMYD2 0.56 12.24 0.44 4.43e-31 IgG glycosylation; BRCA cis rs9287719 0.967 rs4519489 chr2:10739087 A/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg18876405 chr7:65276391 NA 0.48 10.79 0.39 4.64e-25 Aortic root size; BRCA cis rs11190604 1.000 rs11190569 chr10:102227409 C/T cg07080220 chr10:102295463 HIF1AN 0.51 11.68 0.42 1.02e-28 Palmitoleic acid (16:1n-7) levels; BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.6 9.08 0.34 1.29e-18 Renal function-related traits (BUN); BRCA cis rs8180040 1.000 rs7613282 chr3:47389409 C/T cg27129171 chr3:47204927 SETD2 -0.7 -16.77 -0.55 1.37e-52 Colorectal cancer; BRCA cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs360798 0.532 rs360799 chr2:62953166 G/A cg17519650 chr2:63277830 OTX1 -0.36 -7.87 -0.3 1.52e-14 Coronary artery disease; BRCA cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg24642439 chr20:33292090 TP53INP2 -0.42 -8.65 -0.32 4.19e-17 Glomerular filtration rate (creatinine); BRCA cis rs4481887 0.893 rs4512685 chr1:248446246 C/T cg00666640 chr1:248458726 OR2T12 0.32 8.61 0.32 5.63e-17 Common traits (Other); BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg21747090 chr2:27597821 SNX17 -0.45 -9.65 -0.36 1.2e-20 Menopause (age at onset); BRCA cis rs77972916 0.611 rs61552842 chr2:43584036 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.59 -10.13 -0.37 1.8e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs9682041 0.627 rs11924474 chr3:170091333 T/G cg11886554 chr3:170076028 SKIL 0.49 9.93 0.37 1e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg23096020 chr7:158799433 NA -0.37 -8.76 -0.33 1.69e-17 Facial morphology (factor 20); BRCA cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg04414720 chr1:150670196 GOLPH3L 0.36 8.12 0.31 2.4e-15 Tonsillectomy; BRCA cis rs6545883 0.965 rs766447 chr2:61735569 C/T cg15711740 chr2:61764176 XPO1 -0.55 -14.12 -0.49 1.34e-39 Tuberculosis; BRCA cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg18200150 chr17:30822561 MYO1D 0.35 8.91 0.33 5.17e-18 Schizophrenia; BRCA trans rs11098499 0.738 rs10026493 chr4:120384194 C/G cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg01802117 chr1:53393560 SCP2 0.4 8.6 0.32 6e-17 Monocyte count; BRCA cis rs1829883 0.739 rs2461969 chr5:98728440 G/A cg08333243 chr5:99726346 NA 0.34 8.45 0.32 1.98e-16 Hemostatic factors and hematological phenotypes; BRCA trans rs11992162 0.591 rs4240678 chr8:11802426 C/T cg06636001 chr8:8085503 FLJ10661 -0.41 -8.57 -0.32 7.75e-17 Monocyte count; BRCA cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg07952391 chr2:88470173 THNSL2 0.58 8.19 0.31 1.41e-15 Plasma clusterin levels; BRCA cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg18876405 chr7:65276391 NA -0.49 -11.0 -0.4 6.88e-26 Aortic root size; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs713587 0.967 rs713586 chr2:25158008 A/G cg04586622 chr2:25135609 ADCY3 0.39 9.54 0.35 3.04e-20 Body mass index in non-asthmatics; BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg27170947 chr2:26402098 FAM59B -0.66 -11.32 -0.41 3.45e-27 Gut microbiome composition (summer); BRCA trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg13010199 chr12:38710504 ALG10B 0.42 9.01 0.34 2.3e-18 Morning vs. evening chronotype; BRCA cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg24642439 chr20:33292090 TP53INP2 0.43 8.72 0.33 2.37e-17 Height; BRCA cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg11812906 chr14:75593930 NEK9 0.65 15.01 0.51 7.86e-44 Height; BRCA cis rs9462027 0.628 rs9462020 chr6:34751265 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.33e-15 Systemic lupus erythematosus; BRCA cis rs11984145 1.000 rs79643038 chr7:38880129 T/A cg19327137 chr7:38886074 VPS41 0.5 8.65 0.32 4.09e-17 Cognitive performance; BRCA cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg26248373 chr2:1572462 NA -0.5 -9.76 -0.36 4.55e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs921968 0.541 rs4674310 chr2:219318078 T/C cg10223061 chr2:219282414 VIL1 0.29 8.39 0.32 3.07e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg06064525 chr11:970664 AP2A2 -0.49 -16.18 -0.54 1.25e-49 Alzheimer's disease (late onset); BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg03188948 chr7:1209495 NA 0.75 10.95 0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs61931739 0.534 rs7313137 chr12:34010231 T/G cg26384229 chr12:38710491 ALG10B 0.67 13.91 0.48 1.34e-38 Morning vs. evening chronotype; BRCA cis rs10789491 1.000 rs1371834 chr1:47176894 G/A cg15501359 chr1:47185051 KIAA0494 0.66 18.26 0.59 3.04e-60 Response to hepatitis C treatment; BRCA cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg21573476 chr21:45109991 RRP1B 0.44 12.01 0.43 4.15e-30 Mean corpuscular volume; BRCA cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg06092702 chr1:163392909 NA -0.33 -8.87 -0.33 7.5e-18 Motion sickness; BRCA cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.67 0.5 3.17e-42 Personality dimensions; BRCA cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg07917127 chr4:99064746 C4orf37 0.44 8.16 0.31 1.84e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg08888203 chr3:10149979 C3orf24 0.68 14.18 0.49 7.04e-40 Alzheimer's disease; BRCA cis rs495337 0.760 rs2254930 chr20:48527107 T/A cg17835207 chr20:48524531 SPATA2 -0.68 -16.81 -0.55 9.28e-53 Psoriasis; BRCA cis rs7098414 0.511 rs7907575 chr10:82152675 T/G cg00277334 chr10:82204260 NA -0.49 -10.27 -0.38 5.4e-23 Post bronchodilator FEV1; BRCA cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08109568 chr15:31115862 NA 0.42 10.18 0.37 1.19e-22 Huntington's disease progression; BRCA cis rs7267979 1.000 rs2500436 chr20:25406366 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.64 -0.32 4.44e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs953387 0.910 rs13415439 chr2:136930232 C/A cg05194412 chr2:137003533 NA -0.35 -8.01 -0.3 5.37e-15 Arthritis (juvenile idiopathic); BRCA cis rs11190604 1.000 rs10786598 chr10:102291579 G/A cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg06115741 chr20:33292138 TP53INP2 0.51 11.3 0.41 3.92e-27 Coronary artery disease; BRCA cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg12379764 chr21:47803548 PCNT -0.41 -8.54 -0.32 9.84e-17 Testicular germ cell tumor; BRCA cis rs7903847 0.692 rs7900255 chr10:99157575 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.43 -0.32 2.25e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs9814567 0.896 rs7653880 chr3:134345788 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.83 -0.58 5.39e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.38e-19 Menopause (age at onset); BRCA cis rs34779708 0.931 rs4934709 chr10:35339324 A/C cg03585969 chr10:35415529 CREM -0.47 -9.84 -0.36 2.19e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg14036092 chr11:66035641 RAB1B 0.39 10.23 0.38 7.55e-23 Gout; BRCA cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.75 0.62 3.8e-68 Smoking behavior; BRCA cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg04756594 chr16:24857601 SLC5A11 0.5 11.61 0.42 2.12e-28 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6977660 0.652 rs10249291 chr7:19844448 C/G cg05791153 chr7:19748676 TWISTNB 0.77 12.98 0.46 2.22e-34 Thyroid stimulating hormone; BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg08280861 chr8:58055591 NA 0.56 9.1 0.34 1.17e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.779 rs10011097 chr4:120310359 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg17971929 chr21:40555470 PSMG1 -0.47 -10.51 -0.38 6.25e-24 Menarche (age at onset); BRCA trans rs783540 0.656 rs783538 chr15:83253143 C/G cg16105309 chr15:79090380 ADAMTS7 0.33 9.14 0.34 8.11e-19 Schizophrenia; BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg21782813 chr7:2030301 MAD1L1 0.33 9.29 0.35 2.31e-19 Schizophrenia; BRCA cis rs7412746 0.611 rs4509581 chr1:150774465 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.94 0.3 9.2e-15 Melanoma; BRCA cis rs1568889 0.838 rs10458896 chr11:28057957 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 20.22 0.62 1.19e-70 Bipolar disorder; BRCA cis rs10489202 0.608 rs7533646 chr1:168077593 A/C cg24449463 chr1:168025552 DCAF6 -0.47 -14.7 -0.5 2.37e-42 Schizophrenia; BRCA cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs9395066 0.620 rs227831 chr6:44680808 A/G cg25276700 chr6:44698697 NA 0.39 8.27 0.31 7.68e-16 Height; BRCA cis rs4820294 0.669 rs35662099 chr22:38053909 C/T cg21798802 chr22:38057573 PDXP 0.3 8.2 0.31 1.35e-15 Fat distribution (HIV); BRCA cis rs7959452 0.718 rs10878963 chr12:69717166 T/G cg14784868 chr12:69753453 YEATS4 0.37 8.96 0.33 3.45e-18 Blood protein levels; BRCA cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.52 9.91 0.36 1.25e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17641971 0.645 rs4873099 chr8:50025683 G/T cg00325661 chr8:49890786 NA 0.35 9.89 0.36 1.45e-21 Blood metabolite levels; BRCA cis rs2251381 0.722 rs2251278 chr21:30529234 A/G cg24692254 chr21:30365293 RNF160 0.63 13.89 0.48 1.56e-38 Selective IgA deficiency; BRCA cis rs6060717 0.529 rs6060535 chr20:34235522 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.0 -0.34 2.49e-18 Hip circumference adjusted for BMI; BRCA cis rs7523050 0.643 rs12752417 chr1:109400639 A/C cg08274380 chr1:109419600 GPSM2 -0.97 -12.89 -0.45 5.72e-34 Fat distribution (HIV); BRCA cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg23711669 chr6:146136114 FBXO30 0.78 18.79 0.6 4.89e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg25427524 chr10:38739819 LOC399744 -0.66 -16.21 -0.54 9.22e-50 Extrinsic epigenetic age acceleration; BRCA cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg17143192 chr8:8559678 CLDN23 0.54 10.72 0.39 8.93e-25 Obesity-related traits; BRCA cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg14728415 chr7:32535168 LSM5;AVL9 0.4 8.92 0.33 4.75e-18 Cognitive ability; BRCA cis rs6500602 0.627 rs6500610 chr16:4529613 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.39 0.31 3.18e-16 Schizophrenia; BRCA cis rs250677 0.652 rs250670 chr5:148446646 G/T cg23229984 chr5:148520753 ABLIM3 0.36 8.74 0.33 2.06e-17 Breast cancer; BRCA trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.16 0.34 6.77e-19 Morning vs. evening chronotype; BRCA cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15541040 chr2:3486749 NA -0.46 -10.11 -0.37 2.2e-22 Neurofibrillary tangles; BRCA cis rs9790314 1.000 rs7653233 chr3:160992033 G/A cg04691961 chr3:161091175 C3orf57 -0.52 -12.87 -0.45 6.99e-34 Morning vs. evening chronotype; BRCA cis rs16867321 0.853 rs73023563 chr2:181502830 C/T cg23363182 chr2:181467187 NA -0.44 -8.26 -0.31 8.11e-16 Obesity; BRCA cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg01475377 chr6:109611718 NA 0.59 16.4 0.54 1.1e-50 Reticulocyte fraction of red cells; BRCA cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg06784218 chr1:46089804 CCDC17 -0.53 -12.8 -0.45 1.42e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg18230493 chr5:56204884 C5orf35 -0.74 -14.85 -0.51 4.45e-43 Initial pursuit acceleration; BRCA cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg25237894 chr2:233734115 C2orf82 -0.41 -11.81 -0.42 3.12e-29 Coronary artery disease; BRCA cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg09035930 chr12:129282057 SLC15A4 0.58 17.51 0.57 2.2e-56 Systemic lupus erythematosus; BRCA cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -17.44 -0.57 5.43e-56 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.909 rs10002083 chr4:120311152 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs1011018 0.628 rs6967634 chr7:139448455 C/T cg03224163 chr7:139420300 HIPK2 -0.6 -9.01 -0.34 2.35e-18 Systolic blood pressure; BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24549020 chr5:56110836 MAP3K1 0.65 13.24 0.46 1.51e-35 Initial pursuit acceleration; BRCA cis rs10752881 1.000 rs10752886 chr1:182987248 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.17e-52 Colorectal cancer; BRCA cis rs4363385 0.747 rs4845509 chr1:152981900 T/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.13 -0.34 9.03e-19 Inflammatory skin disease; BRCA cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg24642439 chr20:33292090 TP53INP2 -0.54 -11.7 -0.42 8.74e-29 Glomerular filtration rate (creatinine); BRCA cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg03517284 chr6:25882590 NA 0.69 16.02 0.54 8.07e-49 Blood metabolite levels; BRCA cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs10242455 0.571 rs11734 chr7:99229768 C/G cg18809830 chr7:99032528 PTCD1 0.58 8.46 0.32 1.84e-16 Blood metabolite levels; BRCA cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.29 -0.34 2.43e-19 Alzheimer's disease (late onset); BRCA cis rs1863824 0.625 rs11202023 chr10:88165453 C/T cg07322936 chr10:88137208 NA -0.47 -9.41 -0.35 8.52e-20 Schizophrenia; BRCA cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg00651523 chr6:28411279 ZSCAN23 -0.36 -7.81 -0.3 2.28e-14 Pubertal anthropometrics; BRCA trans rs7618501 0.633 rs9866695 chr3:50069452 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.26 -0.34 3.03e-19 Intelligence (multi-trait analysis); BRCA cis rs28374715 0.532 rs28477406 chr15:41642036 C/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -23.57 -0.68 7.36e-89 Ulcerative colitis; BRCA trans rs1941687 0.527 rs6507059 chr18:31303643 A/G cg15819921 chr19:927150 ARID3A -0.44 -8.32 -0.31 5.43e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs9325144 0.555 rs1973292 chr12:38679626 T/C cg23762105 chr12:34175262 ALG10 -0.4 -9.73 -0.36 5.98e-21 Morning vs. evening chronotype; BRCA cis rs7587476 0.682 rs13009646 chr2:215691259 T/A cg04004882 chr2:215674386 BARD1 0.67 12.46 0.44 4.77e-32 Neuroblastoma; BRCA cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg13010199 chr12:38710504 ALG10B 0.45 9.47 0.35 5.17e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs7772486 0.701 rs2244308 chr6:146213706 C/T cg23711669 chr6:146136114 FBXO30 0.67 15.74 0.53 2.07e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg18446336 chr7:2847575 GNA12 0.34 8.03 0.3 4.64e-15 Height; BRCA cis rs9790314 0.521 rs13084746 chr3:161086038 G/A cg03342759 chr3:160939853 NMD3 -0.56 -11.93 -0.43 9.38e-30 Morning vs. evening chronotype; BRCA cis rs11601602 0.576 rs12576396 chr11:28555952 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.49 9.39 0.35 1e-19 Obesity-related traits; BRCA cis rs7267979 1.000 rs2257809 chr20:25266476 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.84 0.36 2.26e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05901451 chr6:126070800 HEY2 0.4 9.72 0.36 6.35e-21 Endometrial cancer; BRCA cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg15662616 chr7:148823355 ZNF425;ZNF398 -0.41 -9.16 -0.34 6.79e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg15395560 chr15:45543142 SLC28A2 0.29 8.17 0.31 1.67e-15 Uric acid levels; BRCA cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg13298116 chr11:62369859 EML3;MTA2 0.58 13.44 0.47 1.88e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1878931 0.535 rs7188903 chr16:3412861 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.48 8.51 0.32 1.21e-16 Body mass index (adult); BRCA cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.39 8.36 0.31 3.95e-16 Alzheimer's disease (late onset); BRCA cis rs9287719 0.967 rs7355649 chr2:10748094 C/A cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.65e-15 Prostate cancer; BRCA cis rs10484885 0.793 rs1465954 chr6:90475013 G/A cg13799429 chr6:90582589 CASP8AP2 0.71 11.03 0.4 5.34e-26 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg26408565 chr15:76604113 ETFA -0.41 -8.76 -0.33 1.77e-17 Blood metabolite levels; BRCA cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12667521 chr19:29218732 NA 0.47 8.75 0.33 1.93e-17 Methadone dose in opioid dependence; BRCA cis rs853679 0.517 rs9295759 chr6:28124469 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg01483505 chr11:975446 AP2A2 0.34 9.11 0.34 1.05e-18 Alzheimer's disease (late onset); BRCA cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.64 0.36 1.24e-20 Motion sickness; BRCA trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg20587970 chr11:113659929 NA 0.91 13.51 0.47 9.08e-37 Hip circumference adjusted for BMI; BRCA cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg23711669 chr6:146136114 FBXO30 -0.8 -19.25 -0.61 1.69e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg11833968 chr6:79620685 NA -0.45 -10.1 -0.37 2.37e-22 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs5758659 0.519 rs133307 chr22:42396568 C/A cg05082376 chr22:42548792 NA -0.31 -7.85 -0.3 1.71e-14 Cognitive function; BRCA cis rs36051895 0.623 rs10975023 chr9:5239549 A/G cg02405213 chr9:5042618 JAK2 0.46 8.44 0.32 2.06e-16 Pediatric autoimmune diseases; BRCA cis rs6546550 0.901 rs897120 chr2:70160982 C/T cg02498382 chr2:70120550 SNRNP27 0.49 10.72 0.39 8.9e-25 Prevalent atrial fibrillation; BRCA cis rs4363385 0.747 rs1577963 chr1:152961882 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.3 -0.35 2.14e-19 Inflammatory skin disease; BRCA cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.49 0.35 4.51e-20 Motion sickness; BRCA cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg07817648 chr10:79422355 NA 0.7 12.83 0.45 1.04e-33 Bone mineral density; BRCA cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg06238570 chr21:40685208 BRWD1 -0.43 -8.5 -0.32 1.33e-16 Cognitive function; BRCA cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg05313129 chr8:58192883 C8orf71 -0.48 -9.84 -0.36 2.23e-21 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.23 -0.34 3.95e-19 Tonsillectomy; BRCA trans rs9291683 0.588 rs6857693 chr4:10018435 G/A cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.34e-16 Bone mineral density; BRCA cis rs9486715 0.838 rs9386576 chr6:96954717 C/T cg06623918 chr6:96969491 KIAA0776 0.89 25.79 0.71 4.53e-101 Headache; BRCA cis rs6570726 0.791 rs414297 chr6:145887556 C/T cg05347473 chr6:146136440 FBXO30 0.39 8.0 0.3 5.85e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs312274 0.569 rs11178878 chr12:41273551 C/T cg17827154 chr12:41323612 CNTN1 0.36 8.98 0.33 3.02e-18 Metabolite levels (X-11787); BRCA cis rs2882667 0.931 rs10070021 chr5:138324706 A/G cg04439458 chr5:138467593 SIL1 -0.33 -9.11 -0.34 1.03e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7301826 0.651 rs10773825 chr12:131298913 G/A cg11011512 chr12:131303247 STX2 0.51 13.57 0.47 4.71e-37 Plasma plasminogen activator levels; BRCA cis rs28374715 0.662 rs522063 chr15:41476209 A/G cg18705301 chr15:41695430 NDUFAF1 0.79 17.01 0.56 8.18e-54 Ulcerative colitis; BRCA cis rs1371614 0.545 rs3769137 chr2:27169490 C/T cg00617064 chr2:27272375 NA 0.31 8.03 0.3 4.65e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9447004 0.584 rs56093139 chr6:74432923 C/T cg03006477 chr6:74432658 CD109 0.33 9.24 0.34 3.55e-19 Blood protein levels;Calcium levels; BRCA cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.15 0.31 1.92e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3008870 0.958 rs12143044 chr1:67460054 A/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs10751667 0.643 rs10902234 chr11:935578 A/G cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg11752832 chr7:134001865 SLC35B4 -0.43 -9.53 -0.35 3.1e-20 Mean platelet volume; BRCA cis rs6580649 1.000 rs3825404 chr12:48399931 A/G cg05342945 chr12:48394962 COL2A1 -0.46 -9.29 -0.34 2.47e-19 Lung cancer; BRCA cis rs7512552 0.809 rs2794679 chr1:150324857 G/A cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.81e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs55882075 0.690 rs12374485 chr5:179131395 G/C cg14593053 chr5:179126677 CANX 0.48 12.65 0.45 7.01e-33 Monocyte percentage of white cells; BRCA cis rs17253792 0.822 rs10083493 chr14:56045411 C/T cg01858014 chr14:56050164 KTN1 -0.79 -11.43 -0.41 1.15e-27 Putamen volume; BRCA cis rs6714710 0.603 rs12988571 chr2:98405695 C/T cg26665480 chr2:98280029 ACTR1B 0.59 13.44 0.47 1.83e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg15017067 chr4:17643749 FAM184B 0.34 10.55 0.39 4.43e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg11752832 chr7:134001865 SLC35B4 0.53 13.75 0.48 7.37e-38 Mean platelet volume; BRCA cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.83 -0.3 1.98e-14 Aortic root size; BRCA cis rs412050 0.502 rs17759796 chr22:22190163 A/C cg17089214 chr22:22089827 YPEL1 -0.55 -7.91 -0.3 1.14e-14 Attention deficit hyperactivity disorder; BRCA cis rs6910061 1.000 rs73445479 chr6:11114770 T/C cg27233058 chr6:11094804 LOC221710 0.53 9.43 0.35 7.64e-20 Diabetic kidney disease; BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg22920501 chr2:26401640 FAM59B -0.9 -16.59 -0.55 1.12e-51 Gut microbiome composition (summer); BRCA cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg00012203 chr2:219082015 ARPC2 -0.52 -10.53 -0.38 5.23e-24 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs2481665 0.806 rs55725347 chr1:62538252 G/A cg18591186 chr1:62594603 INADL -0.57 -12.2 -0.43 6.21e-31 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg16431978 chr21:31797932 KRTAP13-3 0.36 9.16 0.34 6.97e-19 HDL cholesterol; BRCA cis rs6450176 0.909 rs1541681 chr5:53304620 G/T ch.5.1024479R chr5:53302184 ARL15 -0.61 -14.78 -0.5 9.62e-43 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7561273 0.586 rs11900665 chr2:24298198 T/C cg04809136 chr2:24300158 SF3B14 -0.4 -9.27 -0.34 2.74e-19 Quantitative traits; BRCA cis rs3760982 0.585 rs10422108 chr19:44294868 C/T cg12072164 chr19:44306565 LYPD5 0.36 8.75 0.33 1.97e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs943466 0.513 rs755497 chr6:33734419 C/T cg25922239 chr6:33757077 LEMD2 -0.33 -8.11 -0.31 2.62e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.65 10.59 0.39 2.9e-24 Renal function-related traits (BUN); BRCA cis rs4908760 0.868 rs12131864 chr1:8591162 A/G cg20416874 chr1:8611966 RERE -0.29 -8.2 -0.31 1.28e-15 Vitiligo; BRCA cis rs6942756 0.774 rs2566876 chr7:128890055 A/G cg02491457 chr7:128862824 NA 0.58 12.53 0.44 2.36e-32 White matter hyperintensity burden; BRCA cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.79 18.93 0.6 8.87e-64 Multiple sclerosis; BRCA cis rs9394841 0.646 rs9369313 chr6:41847065 C/T cg08135965 chr6:41755394 TOMM6 0.51 8.29 0.31 6.88e-16 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs9325144 0.647 rs12227834 chr12:38849246 G/C cg26384229 chr12:38710491 ALG10B -0.51 -12.16 -0.43 9.48e-31 Morning vs. evening chronotype; BRCA cis rs738322 0.577 rs4820320 chr22:38572977 G/A cg25457927 chr22:38595422 NA -0.25 -8.68 -0.32 3.41e-17 Cutaneous nevi; BRCA cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg11266682 chr4:10021025 SLC2A9 -0.43 -11.43 -0.41 1.15e-27 Bone mineral density; BRCA cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.91 0.37 1.23e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg14829155 chr15:31115871 NA -0.43 -9.97 -0.37 7.15e-22 Huntington's disease progression; BRCA cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.54 -0.32 9.58e-17 Glomerular filtration rate (creatinine); BRCA trans rs9329221 0.662 rs13254942 chr8:10257678 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -9.22 -0.34 4.3e-19 Neuroticism; BRCA cis rs6545883 0.894 rs7566035 chr2:61520815 C/T cg15711740 chr2:61764176 XPO1 0.5 12.24 0.44 4.38e-31 Tuberculosis; BRCA cis rs10838687 0.736 rs4647725 chr11:47245389 T/C cg25783544 chr11:47291846 MADD 0.43 7.86 0.3 1.63e-14 Proinsulin levels; BRCA trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg21095983 chr6:86352623 SYNCRIP 0.42 9.51 0.35 3.75e-20 Smooth-surface caries; BRCA cis rs9814567 0.929 rs13088413 chr3:134309977 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.46 0.61 1.38e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Smoking initiation; BRCA cis rs10751667 0.961 rs7395303 chr11:986221 T/A cg01483505 chr11:975446 AP2A2 0.34 9.22 0.34 4.38e-19 Alzheimer's disease (late onset); BRCA cis rs12497850 0.805 rs6446198 chr3:49007638 T/A cg06212747 chr3:49208901 KLHDC8B 0.46 9.35 0.35 1.48e-19 Parkinson's disease; BRCA cis rs6901250 0.807 rs339303 chr6:117176691 C/T cg12892004 chr6:117198278 RFX6 -0.5 -11.41 -0.41 1.44e-27 C-reactive protein levels; BRCA cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg01028140 chr2:1542097 TPO -0.69 -13.84 -0.48 2.68e-38 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4409675 0.576 rs6700473 chr1:28236682 C/T cg23691781 chr1:28212827 C1orf38 0.33 9.98 0.37 6.92e-22 Corneal astigmatism; BRCA cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg11168104 chr5:1857477 NA -0.33 -8.78 -0.33 1.45e-17 Cardiovascular disease risk factors; BRCA cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg08798685 chr6:27730294 NA -0.72 -8.91 -0.33 5.23e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.625 rs13035260 chr2:201132377 A/G cg23649088 chr2:200775458 C2orf69 -0.53 -8.69 -0.33 3.04e-17 Schizophrenia; BRCA cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.91 -0.3 1.14e-14 Aortic root size; BRCA cis rs12291225 0.679 rs1043237 chr11:14289053 A/T cg19336497 chr11:14380999 RRAS2 -0.46 -11.54 -0.42 4.11e-28 Sense of smell; BRCA cis rs78487399 0.808 rs6705351 chr2:43843137 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -8.16 -0.31 1.74e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.27 0.31 7.9e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.81 -0.3 2.42e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9649213 0.533 rs1541409 chr7:98027580 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.59 -15.82 -0.53 7.81e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs367615 0.918 rs17161889 chr5:108855251 A/G cg17395555 chr5:108820864 NA -0.37 -9.99 -0.37 6.39e-22 Colorectal cancer (SNP x SNP interaction); BRCA cis rs2204008 0.521 rs7311188 chr12:38542813 C/G cg26384229 chr12:38710491 ALG10B -0.44 -10.4 -0.38 1.62e-23 Bladder cancer; BRCA cis rs523522 0.926 rs10774555 chr12:120971978 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.34 0.47 5.7e-36 High light scatter reticulocyte count; BRCA cis rs9469578 1.000 rs73743328 chr6:33713550 G/A cg18708504 chr6:33715942 IP6K3 0.7 10.18 0.37 1.12e-22 Phosphorus levels; BRCA cis rs7582180 0.701 rs4622752 chr2:100892018 A/G cg14675211 chr2:100938903 LONRF2 -0.42 -8.99 -0.33 2.87e-18 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.676 rs13098228 chr3:47138253 A/G cg27129171 chr3:47204927 SETD2 0.77 19.91 0.62 5.34e-69 Colorectal cancer; BRCA cis rs9527 0.590 rs6584537 chr10:104778267 C/G cg04362960 chr10:104952993 NT5C2 0.44 9.92 0.37 1.15e-21 Arsenic metabolism; BRCA cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg06627628 chr2:24431161 ITSN2 -0.57 -9.16 -0.34 7.23e-19 Lymphocyte counts; BRCA cis rs10492096 0.947 rs10849484 chr12:6637941 C/T cg13857086 chr12:6580257 VAMP1 0.43 8.13 0.31 2.29e-15 Hip geometry; BRCA cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg10523679 chr1:76189770 ACADM 0.78 18.69 0.59 1.61e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs7945705 0.846 rs4929911 chr11:8816495 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.49 10.36 0.38 2.37e-23 Hemoglobin concentration; BRCA cis rs7617773 0.780 rs4130522 chr3:48352313 G/A cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg03354898 chr7:1950403 MAD1L1 -0.4 -8.34 -0.31 4.42e-16 Bipolar disorder and schizophrenia; BRCA cis rs8010715 0.848 rs2277483 chr14:24591892 A/G cg23112188 chr14:24563095 PCK2 -0.33 -8.34 -0.31 4.74e-16 IgG glycosylation; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg01305625 chr5:131593812 PDLIM4 0.35 8.28 0.31 7.06e-16 Acylcarnitine levels; BRCA cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg10547057 chr6:26987810 LOC100270746;C6orf41 0.3 8.93 0.33 4.33e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.46e-19 Bipolar disorder; BRCA cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg11822812 chr5:140052017 DND1 -0.3 -8.2 -0.31 1.37e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.87 -0.3 1.49e-14 Electroencephalogram traits; BRCA trans rs877282 0.583 rs10904562 chr10:819058 T/C cg22713356 chr15:30763199 NA 1.03 16.89 0.56 3.36e-53 Uric acid levels; BRCA trans rs79976124 0.876 rs17511913 chr6:66644361 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 11.2 0.41 1.01e-26 Type 2 diabetes; BRCA cis rs921968 0.541 rs514356 chr2:219375018 C/T cg10223061 chr2:219282414 VIL1 -0.27 -7.83 -0.3 2.02e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs912057 0.582 rs1294412 chr6:6739854 A/G cg06612196 chr6:6737390 NA 0.58 14.29 0.49 2.23e-40 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs7100689 0.577 rs873395 chr10:82037215 C/T cg01528321 chr10:82214614 TSPAN14 -0.82 -17.44 -0.57 5.45e-56 Post bronchodilator FEV1; BRCA cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.6e-29 Bipolar disorder; BRCA cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg01475377 chr6:109611718 NA -0.59 -16.46 -0.55 5.05e-51 Reticulocyte fraction of red cells; BRCA cis rs1401999 0.510 rs12634398 chr3:183708405 A/G cg01324343 chr3:183735012 ABCC5 0.48 10.69 0.39 1.18e-24 Anterior chamber depth; BRCA cis rs6087990 0.806 rs4911108 chr20:31375311 A/G cg13636640 chr20:31349939 DNMT3B 0.62 19.22 0.61 2.63e-65 Ulcerative colitis; BRCA cis rs4243830 0.850 rs2412309 chr1:6603151 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -17.72 -0.57 1.8e-57 Body mass index; BRCA cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7789940 0.904 rs6953281 chr7:75946943 C/T cg10167463 chr7:75959203 YWHAG -0.45 -8.82 -0.33 1.06e-17 Multiple sclerosis; BRCA cis rs9649465 0.967 rs2402666 chr7:123285478 A/T cg04330084 chr7:123175371 IQUB -0.31 -8.6 -0.32 6.13e-17 Migraine; BRCA cis rs896854 0.967 rs896853 chr8:95960855 G/C cg26343298 chr8:95960752 TP53INP1 0.28 7.95 0.3 8.76e-15 Type 2 diabetes; BRCA cis rs2120243 0.874 rs2316706 chr3:157160061 A/C cg01018701 chr3:157155998 VEPH1;PTX3 0.44 9.81 0.36 2.85e-21 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs9487051 0.766 rs351748 chr6:109532296 C/T cg21918786 chr6:109611834 NA 0.36 9.61 0.36 1.67e-20 Reticulocyte fraction of red cells; BRCA cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg13798780 chr7:105162888 PUS7 0.45 7.95 0.3 8.55e-15 Bipolar disorder (body mass index interaction); BRCA cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg00012203 chr2:219082015 ARPC2 -0.57 -11.98 -0.43 5.8e-30 Colorectal cancer; BRCA cis rs735860 0.763 rs1346603 chr6:53149262 C/T cg10236188 chr6:53219634 NA 0.39 8.35 0.31 4.28e-16 Glaucoma; BRCA cis rs6433895 1.000 rs11893821 chr2:182017148 A/G cg00481216 chr2:181971175 NA 0.39 9.11 0.34 1.09e-18 Lymphocyte counts; BRCA cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg15556689 chr8:8085844 FLJ10661 -0.35 -9.01 -0.34 2.44e-18 Recombination measurement; BRCA cis rs6426558 0.537 rs488104 chr1:227300277 G/A cg10327440 chr1:227177885 CDC42BPA 0.47 9.34 0.35 1.64e-19 Neutrophil percentage of white cells; BRCA cis rs7572733 0.534 rs696817 chr2:198722225 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.12 0.37 1.95e-22 Dermatomyositis; BRCA cis rs938554 0.542 rs7678287 chr4:10000501 A/G cg00071950 chr4:10020882 SLC2A9 0.42 7.95 0.3 8.23e-15 Blood metabolite levels; BRCA cis rs501916 0.796 rs55961203 chr15:48050518 G/T cg16110827 chr15:48056943 SEMA6D -0.4 -8.51 -0.32 1.27e-16 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs117623576 0.680 rs211415 chr10:32397358 C/T cg03047570 chr10:32398778 NA 0.55 8.47 0.32 1.7e-16 Anti-saccade response; BRCA cis rs6580649 0.943 rs9651993 chr12:48404692 G/A cg05342945 chr12:48394962 COL2A1 -0.52 -10.2 -0.37 9.38e-23 Lung cancer; BRCA trans rs877282 0.628 rs11253435 chr10:824169 T/C cg22713356 chr15:30763199 NA 0.95 15.31 0.52 2.57e-45 Uric acid levels; BRCA cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg12310025 chr6:25882481 NA -0.5 -11.24 -0.41 7.23e-27 Intelligence (multi-trait analysis); BRCA cis rs7737355 0.947 rs6596009 chr5:130608093 C/A cg06307176 chr5:131281290 NA 0.48 8.14 0.31 2.08e-15 Life satisfaction; BRCA cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg05347473 chr6:146136440 FBXO30 -0.43 -8.51 -0.32 1.27e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg03709012 chr19:19516395 GATAD2A 0.81 19.12 0.6 8.79e-65 Tonsillectomy; BRCA cis rs889312 0.500 rs866223 chr5:56125353 A/G cg24531977 chr5:56204891 C5orf35 -0.41 -8.22 -0.31 1.15e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg14926445 chr8:58193284 C8orf71 -0.46 -8.83 -0.33 1.01e-17 Developmental language disorder (linguistic errors); BRCA cis rs2732480 0.577 rs1489108 chr12:48738781 G/A cg04545296 chr12:48745243 ZNF641 0.25 8.31 0.31 5.74e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg04034577 chr2:241836375 C2orf54 -0.57 -14.01 -0.48 4.62e-39 Urinary metabolites; BRCA cis rs2658782 0.724 rs1869914 chr11:93112492 C/G cg15737290 chr11:93063684 CCDC67 0.47 9.51 0.35 3.87e-20 Pulmonary function decline; BRCA cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg12573674 chr2:1569213 NA -0.51 -9.72 -0.36 6.58e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7395581 0.918 rs61896050 chr11:47309063 T/C cg25783544 chr11:47291846 MADD 0.43 9.76 0.36 4.41e-21 HDL cholesterol; BRCA cis rs1355223 0.506 rs7131229 chr11:34869328 A/G cg11058730 chr11:34937778 PDHX;APIP 0.49 9.65 0.36 1.16e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12310956 0.532 rs1352210 chr12:33983187 A/G cg06521331 chr12:34319734 NA -0.53 -10.6 -0.39 2.71e-24 Morning vs. evening chronotype; BRCA cis rs6973256 0.897 rs12333918 chr7:133330374 T/G cg07491979 chr7:133331646 EXOC4 -0.39 -8.8 -0.33 1.22e-17 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg05234568 chr11:5960015 NA -0.41 -7.95 -0.3 8.48e-15 DNA methylation (variation); BRCA cis rs250677 0.687 rs250671 chr5:148446523 T/C cg12140854 chr5:148520817 ABLIM3 -0.42 -8.69 -0.33 3.04e-17 Breast cancer; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 18.4 0.59 5.27e-61 Platelet count; BRCA cis rs1065852 0.503 rs9620006 chr22:42399547 T/A cg22189786 chr22:42395067 WBP2NL 0.41 8.32 0.31 5.29e-16 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg02780029 chr10:43622663 RET 0.36 8.12 0.31 2.43e-15 Hirschsprung disease; BRCA trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.81 0.36 2.99e-21 Morning vs. evening chronotype; BRCA cis rs1451375 0.698 rs11489736 chr7:50645372 G/A cg18232548 chr7:50535776 DDC 0.39 9.19 0.34 5.5e-19 Malaria; BRCA cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.99 14.79 0.51 8.45e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3008870 1.000 rs3008871 chr1:67419089 A/G cg08660285 chr1:67390436 MIER1;WDR78 -1.03 -22.71 -0.67 3.62e-84 Lymphocyte percentage of white cells; BRCA cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs12532878 0.652 rs11768465 chr7:100198386 C/T cg16850897 chr7:100343110 ZAN -0.39 -8.27 -0.31 7.99e-16 Mean corpuscular hemoglobin; BRCA cis rs1941023 0.584 rs2014121 chr11:60156297 T/C cg08716584 chr11:60157161 MS4A7 -0.43 -10.46 -0.38 9.49e-24 Congenital heart disease (maternal effect); BRCA trans rs7819412 0.505 rs17782536 chr8:11021682 A/G cg15556689 chr8:8085844 FLJ10661 -0.33 -7.96 -0.3 7.93e-15 Triglycerides; BRCA cis rs3820928 0.874 rs13385711 chr2:227830414 G/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.81e-16 Pulmonary function; BRCA cis rs1190552 0.639 rs3742446 chr14:102975572 C/T cg18135206 chr14:102964638 TECPR2 0.43 7.87 0.3 1.48e-14 Blood protein levels; BRCA cis rs8177179 0.967 rs4994582 chr3:133437566 G/C cg16262614 chr3:133464971 TF 0.24 7.88 0.3 1.45e-14 Iron status biomarkers (transferrin levels); BRCA cis rs68170813 0.559 rs76020313 chr7:106877468 A/G cg02696742 chr7:106810147 HBP1 -0.51 -8.43 -0.32 2.25e-16 Coronary artery disease; BRCA cis rs7264396 0.690 rs2425165 chr20:34438059 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.13 0.31 2.28e-15 Total cholesterol levels; BRCA cis rs6942756 0.737 rs61570833 chr7:128933492 C/A cg02491457 chr7:128862824 NA -0.71 -13.84 -0.48 2.81e-38 White matter hyperintensity burden; BRCA cis rs40363 0.680 rs72778116 chr16:3530752 A/G cg22508957 chr16:3507546 NAT15 0.64 8.33 0.31 4.87e-16 Tuberculosis; BRCA cis rs7246657 0.943 rs10415358 chr19:37808863 C/A cg23950597 chr19:37808831 NA -0.72 -12.52 -0.44 2.54e-32 Coronary artery calcification; BRCA cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg19628046 chr18:33552617 C18orf21 0.52 10.77 0.39 5.52e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4389656 0.826 rs192443 chr5:6733664 G/T cg10857441 chr5:6722123 POLS -0.25 -7.83 -0.3 2.08e-14 Coronary artery disease; BRCA cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.37e-39 Initial pursuit acceleration; BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.69 0.33 3.03e-17 Platelet count; BRCA cis rs10883723 0.962 rs1056740 chr10:104236552 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.6 17.47 0.57 3.62e-56 Allergic disease (asthma, hay fever or eczema); BRCA trans rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14026747 chr4:135865398 NA 0.46 8.96 0.33 3.42e-18 Menarche (age at onset); BRCA cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg26384229 chr12:38710491 ALG10B 0.7 15.88 0.53 4.21e-48 Bladder cancer; BRCA cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg07092213 chr7:1199455 ZFAND2A -0.5 -10.71 -0.39 9.57e-25 Longevity;Endometriosis; BRCA cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs13102973 0.640 rs6833827 chr4:135839731 T/C cg14419869 chr4:135874104 NA 0.45 9.09 0.34 1.24e-18 Subjective well-being; BRCA cis rs4243830 0.850 rs932112 chr1:6591937 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -17.81 -0.58 6.35e-58 Body mass index; BRCA trans rs2736340 0.539 rs11250138 chr8:11323312 C/G cg06636001 chr8:8085503 FLJ10661 -0.44 -8.69 -0.33 3.12e-17 Systemic lupus erythematosus and Systemic sclerosis;Rheumatoid arthritis;Systemic lupus erythematosus;Kawasaki disease;Systemic lupus erythematosus or rheumatoid arthritis; BRCA cis rs9768139 0.708 rs11771764 chr7:158119871 A/G cg24154853 chr7:158122151 PTPRN2 0.35 7.98 0.3 6.82e-15 Calcium levels; BRCA cis rs8180040 0.966 rs6792488 chr3:47503349 C/T cg27129171 chr3:47204927 SETD2 -0.68 -16.13 -0.54 2.33e-49 Colorectal cancer; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00166722 chr3:10149974 C3orf24 -0.65 -13.08 -0.46 7.93e-35 Alzheimer's disease; BRCA cis rs6546550 0.935 rs2872075 chr2:70068635 G/T cg02498382 chr2:70120550 SNRNP27 -0.52 -10.84 -0.39 3.05e-25 Prevalent atrial fibrillation; BRCA cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.05 0.34 1.68e-18 Lymphocyte counts; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg04944784 chr2:26401820 FAM59B -0.97 -16.58 -0.55 1.35e-51 Gut microbiome composition (summer); BRCA cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg12219531 chr12:120966889 COQ5 0.53 11.64 0.42 1.58e-28 High light scatter reticulocyte count; BRCA cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.58 -0.32 7.39e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6867032 0.958 rs4463207 chr5:2017118 G/T cg26168224 chr5:2018326 NA 0.63 17.6 0.57 7.82e-57 Gut microbiome composition (winter); BRCA cis rs889312 0.500 rs832577 chr5:56163787 G/A cg24531977 chr5:56204891 C5orf35 -0.4 -8.07 -0.3 3.5e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg08807101 chr21:30365312 RNF160 -0.44 -9.34 -0.35 1.51e-19 Dental caries; BRCA cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.27 -0.41 5.2e-27 Colorectal cancer; BRCA cis rs765787 0.530 rs12906537 chr15:45520061 T/C cg24006582 chr15:45444508 DUOX1 0.55 10.8 0.39 4.45e-25 Uric acid levels; BRCA cis rs698813 0.851 rs698804 chr2:44699720 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 8.81 0.33 1.18e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11141652 chr22:24348549 GSTTP1 -0.39 -7.94 -0.3 8.8e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs509477 1.000 rs7245165 chr18:32567007 C/A cg23791764 chr18:32556832 MAPRE2 0.35 8.33 0.31 5.03e-16 Cerebrospinal fluid AB1-42 levels; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.58 -9.79 -0.36 3.59e-21 Gut microbiome composition (summer); BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13732083 chr21:47605072 C21orf56 0.38 7.81 0.3 2.29e-14 Testicular germ cell tumor; BRCA cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg12011299 chr4:100065546 ADH4 0.42 10.52 0.38 5.44e-24 Alcohol dependence; BRCA cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg08564027 chr20:61660810 NA 0.9 23.66 0.68 2.44e-89 Prostate cancer (SNP x SNP interaction); BRCA cis rs897080 0.552 rs1067383 chr2:44645911 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.42 0.35 7.79e-20 Height; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg23131131 chr22:24373011 LOC391322 0.43 9.9 0.36 1.35e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10227331 0.692 rs34036749 chr7:157298870 T/C cg04156418 chr7:157293606 NA 0.35 10.05 0.37 3.51e-22 Inattentive symptoms; BRCA cis rs4908760 0.864 rs6674832 chr1:8691879 T/C cg20416874 chr1:8611966 RERE -0.28 -8.11 -0.31 2.66e-15 Vitiligo; BRCA cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg23583168 chr7:148888333 NA -0.78 -18.85 -0.6 2.33e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10464366 0.957 rs12667577 chr7:39095133 T/G cg18850127 chr7:39170497 POU6F2 0.39 8.31 0.31 5.58e-16 IgG glycosylation; BRCA cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.68 15.79 0.53 1.18e-47 Axial length; BRCA trans rs61931739 0.635 rs1486884 chr12:33908876 A/T cg26384229 chr12:38710491 ALG10B -0.43 -9.84 -0.36 2.2e-21 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg08219700 chr8:58056026 NA 0.47 8.51 0.32 1.21e-16 Developmental language disorder (linguistic errors); BRCA trans rs9951602 0.512 rs9958497 chr18:76655296 G/C cg02800362 chr5:177631904 HNRNPAB 0.78 18.16 0.58 1.01e-59 Obesity-related traits; BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.83 -12.56 -0.44 1.73e-32 Platelet count; BRCA cis rs6977660 0.660 rs10253753 chr7:19823032 A/G cg05791153 chr7:19748676 TWISTNB 0.57 10.8 0.39 4.43e-25 Thyroid stimulating hormone; BRCA cis rs919433 0.679 rs13000656 chr2:198522126 T/C cg00792783 chr2:198669748 PLCL1 -0.44 -9.38 -0.35 1.12e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2806561 0.734 rs2143156 chr1:23374629 T/G cg19743168 chr1:23544995 NA 0.36 8.38 0.31 3.28e-16 Height; BRCA cis rs9300255 0.722 rs12322888 chr12:123825559 A/G cg00376283 chr12:123451042 ABCB9 0.47 10.81 0.39 4.12e-25 Neutrophil percentage of white cells; BRCA cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs9341808 0.667 rs2490244 chr6:80891112 A/T cg08355045 chr6:80787529 NA 0.33 8.09 0.3 3.07e-15 Sitting height ratio; BRCA cis rs10089 0.552 rs11955148 chr5:127557814 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.5 10.04 0.37 4.17e-22 Ileal carcinoids; BRCA cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg24692254 chr21:30365293 RNF160 -0.35 -8.06 -0.3 3.7e-15 Pancreatic cancer; BRCA cis rs9462027 0.675 rs7755926 chr6:34722574 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.27 -8.25 -0.31 9.32e-16 Systemic lupus erythematosus; BRCA cis rs55665837 1.000 rs12792120 chr11:14469443 G/T cg19336497 chr11:14380999 RRAS2 -0.37 -9.66 -0.36 1.04e-20 Vitamin D levels; BRCA cis rs6763687 0.964 rs16856838 chr3:171775451 G/A cg16233210 chr3:171778391 FNDC3B 0.48 11.34 0.41 2.88e-27 Red cell distribution width; BRCA cis rs2839186 0.558 rs2968 chr21:47608580 C/T cg12379764 chr21:47803548 PCNT 0.39 8.44 0.32 2.07e-16 Testicular germ cell tumor; BRCA cis rs1348850 0.914 rs12104588 chr2:178253675 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.9 0.36 1.32e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg04450456 chr4:17643702 FAM184B 0.38 11.21 0.41 9.12e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2652834 1.000 rs2652835 chr15:63396408 T/C cg05507819 chr15:63340323 TPM1 0.47 8.65 0.32 4.18e-17 HDL cholesterol; BRCA cis rs13046373 0.535 rs1961167 chr21:32030310 T/C cg24082983 chr21:31802169 KRTAP13-4 0.33 8.21 0.31 1.26e-15 HDL cholesterol; BRCA cis rs9486719 1.000 rs2273622 chr6:97058567 A/G cg06623918 chr6:96969491 KIAA0776 -0.77 -13.62 -0.47 2.78e-37 Migraine;Coronary artery disease; BRCA trans rs3960554 0.808 rs59882870 chr7:75638421 G/A cg19862616 chr7:65841803 NCRNA00174 0.52 10.0 0.37 5.67e-22 Eotaxin levels; BRCA cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg02574844 chr11:5959923 NA -0.45 -9.02 -0.34 2.22e-18 DNA methylation (variation); BRCA cis rs7523050 0.643 rs34572569 chr1:109401856 A/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12756686 chr19:29218302 NA 0.57 10.97 0.4 9.04e-26 Methadone dose in opioid dependence; BRCA trans rs8073060 0.586 rs6505487 chr17:33996850 A/G cg19694781 chr19:47549865 TMEM160 -1.02 -20.87 -0.64 3.87e-74 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg08213375 chr14:104286397 PPP1R13B 0.41 8.82 0.33 1.09e-17 Reticulocyte count; BRCA cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg22800045 chr5:56110881 MAP3K1 -0.45 -9.04 -0.34 1.84e-18 Initial pursuit acceleration; BRCA cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.45e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg25237894 chr2:233734115 C2orf82 0.4 11.51 0.41 5.56e-28 Coronary artery disease; BRCA cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg24531977 chr5:56204891 C5orf35 -0.79 -15.1 -0.51 2.72e-44 Initial pursuit acceleration; BRCA cis rs1401999 1.000 rs7620350 chr3:183710053 A/T cg20387954 chr3:183756860 HTR3D 0.46 10.31 0.38 3.71e-23 Anterior chamber depth; BRCA cis rs6433895 0.736 rs13012524 chr2:181985834 G/A cg00481216 chr2:181971175 NA 0.41 8.74 0.33 2.02e-17 Lymphocyte counts; BRCA cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg17063962 chr7:91808500 NA -0.52 -12.17 -0.43 8.52e-31 Breast cancer; BRCA cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg19761014 chr17:28927070 LRRC37B2 0.58 8.24 0.31 1.01e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg05707623 chr12:122985044 ZCCHC8 0.5 9.68 0.36 8.65e-21 Body mass index; BRCA trans rs75804782 0.521 rs56121087 chr2:239435766 A/G cg01134436 chr17:81009848 B3GNTL1 0.69 8.81 0.33 1.17e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs11711311 1.000 rs9827682 chr3:113450251 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.1 -0.37 2.47e-22 IgG glycosylation; BRCA cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg00631329 chr6:26305371 NA 0.44 13.17 0.46 3.2e-35 Educational attainment; BRCA cis rs593982 0.920 rs4930298 chr11:65448108 T/A cg08755490 chr11:65554678 OVOL1 -1.23 -14.75 -0.5 1.37e-42 Atopic dermatitis; BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -10.7 -0.39 1.08e-24 Alzheimer's disease; BRCA trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg25214090 chr10:38739885 LOC399744 0.54 12.08 0.43 2.12e-30 Corneal astigmatism; BRCA cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.3 10.11 0.37 2.19e-22 Bipolar disorder; BRCA cis rs6088813 1.000 rs6579234 chr20:33983485 A/G cg14752227 chr20:34000481 UQCC -0.39 -8.33 -0.31 4.79e-16 Height; BRCA cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg11644478 chr21:40555479 PSMG1 0.75 15.22 0.52 6.94e-45 Cognitive function; BRCA cis rs1215050 0.740 rs804051 chr4:98935935 A/T cg05340658 chr4:99064831 C4orf37 -0.47 -10.92 -0.4 1.41e-25 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.09 -0.37 2.62e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6835098 0.961 rs28709762 chr4:174099149 T/C cg08422745 chr4:174089978 GALNT7 -0.78 -15.87 -0.53 4.43e-48 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1551570 0.755 rs2290687 chr19:10229521 C/T cg16327482 chr19:10226339 EIF3G 0.39 10.08 0.37 2.88e-22 Narcolepsy; BRCA cis rs3771570 0.901 rs10190033 chr2:242412358 A/C cg21155796 chr2:242212141 HDLBP 0.47 8.3 0.31 6.11e-16 Prostate cancer; BRCA cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.69 0.42 9.8e-29 Homoarginine levels; BRCA cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg14061069 chr19:46274453 DMPK 0.65 18.52 0.59 1.33e-61 Coronary artery disease; BRCA trans rs1493916 0.967 rs34341086 chr18:31400141 C/T cg27147174 chr7:100797783 AP1S1 -0.52 -10.24 -0.38 7.01e-23 Life satisfaction; BRCA cis rs11758351 0.660 rs16891446 chr6:26226996 A/C cg01420254 chr6:26195488 NA 0.55 8.64 0.32 4.59e-17 Gout;Renal underexcretion gout; BRCA cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg24296786 chr1:45957014 TESK2 0.62 15.49 0.52 3.59e-46 High light scatter reticulocyte count; BRCA cis rs10782582 0.668 rs7516477 chr1:76204502 C/G cg03433033 chr1:76189801 ACADM -0.37 -8.0 -0.3 6.02e-15 Daytime sleep phenotypes; BRCA cis rs2115630 1.000 rs11073730 chr15:85354596 C/T cg12863693 chr15:85201151 NMB -0.35 -8.44 -0.32 2.1e-16 P wave terminal force; BRCA cis rs208520 0.526 rs9294682 chr6:66795159 G/A cg07460842 chr6:66804631 NA -1.18 -38.66 -0.84 2e-169 Exhaled nitric oxide output; BRCA cis rs9815354 0.812 rs57162396 chr3:41896031 G/A cg03022575 chr3:42003672 ULK4 0.68 9.46 0.35 5.93e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs4481887 0.927 rs4376768 chr1:248476088 A/G cg00666640 chr1:248458726 OR2T12 -0.3 -8.59 -0.32 6.89e-17 Common traits (Other); BRCA cis rs9354352 0.784 rs2062327 chr6:66689923 C/G cg07460842 chr6:66804631 NA -0.69 -14.83 -0.51 5.63e-43 Initial pursuit acceleration in psychotic disorders; BRCA cis rs4478137 0.931 rs7665672 chr4:164236875 G/A cg06758707 chr4:164254230 NPY1R 0.57 12.52 0.44 2.5e-32 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs265548 0.538 rs36688 chr19:17911212 A/C cg16744531 chr19:17905626 B3GNT3 0.55 11.9 0.43 1.22e-29 Tumor biomarkers; BRCA trans rs7980799 1.000 rs7980799 chr12:33576990 A/C cg26384229 chr12:38710491 ALG10B -0.42 -8.63 -0.32 4.89e-17 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg18225595 chr11:63971243 STIP1 0.53 9.6 0.35 1.82e-20 Mean platelet volume; BRCA cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg27129171 chr3:47204927 SETD2 0.7 16.5 0.55 3.23e-51 Colorectal cancer; BRCA trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.13 -18.59 -0.59 5.48e-62 Hemostatic factors and hematological phenotypes; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg18402987 chr7:1209562 NA 0.85 12.22 0.44 5.38e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg12034118 chr1:209979487 IRF6 0.63 16.3 0.54 3.38e-50 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs2486288 0.586 rs12909883 chr15:45572054 G/C cg15395560 chr15:45543142 SLC28A2 0.29 7.95 0.3 8.67e-15 Glomerular filtration rate; BRCA cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg24692254 chr21:30365293 RNF160 -0.66 -17.95 -0.58 1.26e-58 Dental caries; BRCA cis rs12579753 1.000 rs7975863 chr12:82227288 C/T cg07988820 chr12:82153109 PPFIA2 -0.63 -10.13 -0.37 1.78e-22 Resting heart rate; BRCA cis rs17253792 0.822 rs8013714 chr14:56172286 T/C cg01858014 chr14:56050164 KTN1 -0.58 -9.01 -0.34 2.31e-18 Putamen volume; BRCA cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.23e-36 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.621 rs7394862 chr11:927500 T/C ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs965469 0.843 rs6139122 chr20:3395871 T/G cg25506879 chr20:3388711 C20orf194 -0.57 -10.96 -0.4 9.79e-26 IFN-related cytopenia; BRCA cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg26647111 chr11:31128758 NA -0.42 -8.88 -0.33 6.94e-18 Red blood cell count; BRCA cis rs10751667 0.666 rs7394958 chr11:965944 C/G ch.11.42038R chr11:967971 AP2A2 0.52 16.51 0.55 2.86e-51 Alzheimer's disease (late onset); BRCA cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg22431228 chr1:16359049 CLCNKA -0.49 -11.0 -0.4 6.86e-26 Systolic blood pressure; BRCA cis rs6740322 0.793 rs9808360 chr2:43546835 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -12.12 -0.43 1.42e-30 Coronary artery disease; BRCA cis rs2120243 0.791 rs7615621 chr3:157152600 A/T cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.59 0.35 1.95e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg25427524 chr10:38739819 LOC399744 -0.72 -17.76 -0.57 1.13e-57 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg16606324 chr3:10149918 C3orf24 0.56 9.78 0.36 3.7e-21 Alzheimer's disease; BRCA cis rs7092929 0.883 rs705458 chr10:3611415 C/T cg14308648 chr10:3568949 NA -0.46 -8.37 -0.31 3.52e-16 Coronary artery calcification; BRCA cis rs3772130 0.962 rs28660600 chr3:121482637 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.89 0.4 1.96e-25 Cognitive performance; BRCA cis rs12638540 0.543 rs12487678 chr3:32603358 A/C cg11605617 chr3:32612461 DYNC1LI1 0.77 11.54 0.42 3.91e-28 Mortality in heart failure; BRCA cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg05340658 chr4:99064831 C4orf37 0.7 16.97 0.56 1.42e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg00080972 chr5:178986291 RUFY1 0.47 12.46 0.44 4.79e-32 Lung cancer; BRCA cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg22875332 chr1:76189707 ACADM 0.69 14.94 0.51 1.65e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg07092213 chr7:1199455 ZFAND2A -0.52 -11.21 -0.41 9.63e-27 Longevity;Endometriosis; BRCA cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg08859206 chr1:53392774 SCP2 -0.41 -8.17 -0.31 1.6e-15 Monocyte count; BRCA cis rs16854884 0.657 rs7610378 chr3:143711298 G/A cg06585982 chr3:143692056 C3orf58 0.41 8.49 0.32 1.45e-16 Economic and political preferences (feminism/equality); BRCA cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg02297831 chr4:17616191 MED28 0.35 8.07 0.3 3.52e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs889312 0.500 rs832566 chr5:56151744 C/T cg24531977 chr5:56204891 C5orf35 -0.39 -8.03 -0.3 4.67e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs2243480 1.000 rs316325 chr7:65609518 G/A cg18252515 chr7:66147081 NA -1.04 -15.46 -0.52 5.05e-46 Diabetic kidney disease; BRCA cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 8.46 0.32 1.86e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs35740288 0.822 rs17574774 chr15:86233370 C/T cg20737812 chr15:86336631 KLHL25 0.32 7.82 0.3 2.12e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg18016565 chr1:150552671 MCL1 0.35 8.26 0.31 8.2e-16 Tonsillectomy; BRCA cis rs798554 0.548 rs1639064 chr7:2896544 G/A cg13628971 chr7:2884303 GNA12 0.46 10.24 0.38 6.9e-23 Height; BRCA cis rs10493773 1.000 rs12754358 chr1:86248431 C/T cg17807903 chr1:86174739 ZNHIT6 -0.46 -9.47 -0.35 5.53e-20 Urate levels in overweight individuals; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg21280719 chr6:42927975 GNMT -0.33 -13.91 -0.48 1.34e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs3820928 0.874 rs10178731 chr2:227874232 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.27 -0.31 7.98e-16 Pulmonary function; BRCA cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.88 0.51 3.12e-43 Colorectal cancer; BRCA cis rs17376456 0.825 rs6874766 chr5:93213807 C/G cg21475434 chr5:93447410 FAM172A -0.69 -8.61 -0.32 5.74e-17 Diabetic retinopathy; BRCA cis rs13136331 0.680 rs2732169 chr4:88656433 C/T cg12990093 chr4:88570587 DMP1 -0.4 -8.22 -0.31 1.14e-15 Sitting height ratio; BRCA trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg15704280 chr7:45808275 SEPT13 0.62 10.32 0.38 3.42e-23 Axial length; BRCA cis rs11971779 0.680 rs6963867 chr7:139059964 T/G cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs61931739 0.534 rs7965503 chr12:34199349 A/G cg06521331 chr12:34319734 NA -0.65 -11.93 -0.43 9.53e-30 Morning vs. evening chronotype; BRCA cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs17376456 1.000 rs6867042 chr5:93555761 C/T cg21475434 chr5:93447410 FAM172A 0.71 8.97 0.33 3.15e-18 Diabetic retinopathy; BRCA cis rs758324 0.947 rs804059 chr5:131270136 T/C cg06307176 chr5:131281290 NA -0.53 -10.15 -0.37 1.49e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg04450456 chr4:17643702 FAM184B 0.33 9.57 0.35 2.35e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs911555 0.755 rs8014800 chr14:103946302 T/C cg17675199 chr6:35436792 RPL10A -0.3 -8.14 -0.31 2e-15 Intelligence (multi-trait analysis); BRCA cis rs753778 0.628 rs1045248 chr8:142204326 C/G cg18755752 chr8:142205143 DENND3 -0.63 -16.36 -0.54 1.71e-50 Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7246657 0.941 rs67293224 chr19:37803248 C/T cg23950597 chr19:37808831 NA -0.71 -12.02 -0.43 3.68e-30 Coronary artery calcification; BRCA cis rs7395581 0.918 rs10501321 chr11:47294626 A/G cg25783544 chr11:47291846 MADD 0.39 8.92 0.33 4.83e-18 HDL cholesterol; BRCA cis rs2832191 0.791 rs2251517 chr21:30531951 T/G cg08807101 chr21:30365312 RNF160 0.68 17.5 0.57 2.59e-56 Dental caries; BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg04025307 chr7:1156635 C7orf50 0.54 10.61 0.39 2.52e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.954 rs4309825 chr4:120314881 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.34 -8.07 -0.3 3.56e-15 Corneal astigmatism; BRCA cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.28 -0.34 2.63e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.17 -0.4 1.39e-26 Extrinsic epigenetic age acceleration; BRCA cis rs12200560 0.505 rs4839849 chr6:97076673 T/C cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs9811920 0.809 rs923472 chr3:99758029 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.57 -13.61 -0.47 3.16e-37 Axial length; BRCA cis rs4908760 0.864 rs6701331 chr1:8670206 A/C cg20416874 chr1:8611966 RERE -0.28 -7.97 -0.3 7.38e-15 Vitiligo; BRCA cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg08807101 chr21:30365312 RNF160 -0.53 -13.16 -0.46 3.57e-35 Dental caries; BRCA cis rs4595586 0.545 rs7952765 chr12:39375325 C/G cg26384229 chr12:38710491 ALG10B 0.42 9.35 0.35 1.44e-19 Morning vs. evening chronotype; BRCA cis rs1538970 0.924 rs10890327 chr1:45891458 C/T cg05343316 chr1:45956843 TESK2 0.62 12.48 0.44 3.73e-32 Platelet count; BRCA cis rs1568889 1.000 rs12808162 chr11:28067027 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.61 0.5 6.1e-42 Bipolar disorder; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs7599312 0.963 rs10184221 chr2:213409014 G/A cg16329650 chr2:213403929 ERBB4 0.45 9.59 0.35 1.96e-20 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg21573476 chr21:45109991 RRP1B -0.46 -12.06 -0.43 2.61e-30 Mean corpuscular volume; BRCA cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.36 -0.35 1.31e-19 Tonsillectomy; BRCA cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg24324837 chr19:49891574 CCDC155 0.43 7.99 0.3 6.13e-15 Multiple sclerosis; BRCA cis rs760805 1.000 rs4649037 chr1:25258301 G/T cg22509179 chr1:25234806 RUNX3 -0.57 -14.67 -0.5 3.23e-42 Allergic disease (asthma, hay fever or eczema); BRCA cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.68 0.36 9.22e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.866 rs12499602 chr4:120284387 T/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg04025307 chr7:1156635 C7orf50 0.51 9.82 0.36 2.77e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg11663144 chr21:46675770 NA -0.61 -14.26 -0.49 3.01e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7715811 1.000 rs7715552 chr5:13769959 A/T cg07548982 chr5:13769939 DNAH5 -0.38 -8.56 -0.32 8.25e-17 Subclinical atherosclerosis traits (other); BRCA cis rs701145 0.586 rs355785 chr3:153990251 T/G cg17054900 chr3:154042577 DHX36 0.68 11.76 0.42 4.97e-29 Coronary artery disease; BRCA cis rs2816062 0.813 rs6698315 chr1:18895806 A/G cg18795169 chr1:18902165 NA -0.94 -27.92 -0.74 9.25e-113 Urate levels in lean individuals; BRCA cis rs793571 0.523 rs7163162 chr15:58983588 T/A cg05156742 chr15:59063176 FAM63B 0.56 11.58 0.42 2.84e-28 Schizophrenia; BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.46 -0.35 6.03e-20 Total body bone mineral density; BRCA cis rs9527 0.640 rs6584541 chr10:104929124 A/G cg04362960 chr10:104952993 NT5C2 0.43 9.72 0.36 6.14e-21 Arsenic metabolism; BRCA cis rs9527 0.590 rs943039 chr10:104825132 C/T cg04362960 chr10:104952993 NT5C2 0.43 9.77 0.36 4.15e-21 Arsenic metabolism; BRCA trans rs11098499 0.691 rs9995716 chr4:120264996 T/C cg25214090 chr10:38739885 LOC399744 0.42 9.67 0.36 9.88e-21 Corneal astigmatism; BRCA cis rs4363385 0.747 rs6665575 chr1:152960506 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.16 -0.31 1.74e-15 Inflammatory skin disease; BRCA cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.98 0.48 5.96e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg03676636 chr4:99064102 C4orf37 0.23 8.04 0.3 4.26e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg06026331 chr20:60912101 LAMA5 0.49 10.22 0.37 8.21e-23 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 8.46 0.32 1.84e-16 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 9.83 0.36 2.59e-21 Aortic root size; BRCA cis rs6840360 0.615 rs72728171 chr4:152469372 C/A cg22705602 chr4:152727874 NA -0.33 -8.02 -0.3 5.22e-15 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.559 rs1018946 chr7:106851754 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.47 -0.32 1.72e-16 Coronary artery disease; BRCA cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg26395211 chr5:140044315 WDR55 0.38 8.65 0.32 4.31e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg26874164 chr19:58962979 ZNF324B -0.51 -11.24 -0.41 7.44e-27 Uric acid clearance; BRCA cis rs2204008 0.775 rs3900361 chr12:38238936 A/G cg13010199 chr12:38710504 ALG10B -0.4 -8.13 -0.31 2.3e-15 Bladder cancer; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg15112475 chr7:1198522 ZFAND2A -0.54 -12.05 -0.43 2.71e-30 Longevity;Endometriosis; BRCA cis rs7100689 0.753 rs1361458 chr10:82090339 A/T cg00277334 chr10:82204260 NA -0.42 -8.07 -0.3 3.42e-15 Post bronchodilator FEV1; BRCA cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg19628046 chr18:33552617 C18orf21 0.55 10.58 0.39 3.18e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg11764359 chr7:65958608 NA 0.68 15.2 0.52 8.76e-45 Aortic root size; BRCA cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg05985134 chr18:33552581 C18orf21 -0.64 -12.37 -0.44 1.15e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7395581 0.918 rs12575456 chr11:47326073 G/A cg25783544 chr11:47291846 MADD 0.43 9.64 0.36 1.23e-20 HDL cholesterol; BRCA cis rs921968 0.608 rs832817 chr2:219358603 C/T cg02176678 chr2:219576539 TTLL4 0.38 10.2 0.37 9.8e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg02951883 chr7:2050386 MAD1L1 -0.5 -11.5 -0.41 5.78e-28 Bipolar disorder and schizophrenia; BRCA cis rs2777491 0.915 rs8036498 chr15:41603276 A/G cg18705301 chr15:41695430 NDUFAF1 -0.62 -14.14 -0.49 1.13e-39 Ulcerative colitis; BRCA cis rs10851411 0.688 rs17709596 chr15:42767981 C/T cg21293051 chr15:42870591 STARD9 0.51 8.4 0.32 2.94e-16 Glucose homeostasis traits; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg11905131 chr22:24372483 LOC391322 -0.53 -12.2 -0.43 6.53e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg21573476 chr21:45109991 RRP1B -0.39 -10.46 -0.38 1e-23 Mean corpuscular volume; BRCA cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 12.11 0.43 1.56e-30 Rheumatoid arthritis; BRCA cis rs17021463 0.902 rs2865352 chr4:95253263 A/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.38 -0.38 2.0500000000000001e-23 Testicular germ cell tumor; BRCA cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg04756594 chr16:24857601 SLC5A11 0.49 9.46 0.35 5.59e-20 Intelligence (multi-trait analysis); BRCA cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg18351406 chr4:77819688 ANKRD56 0.56 12.57 0.45 1.47e-32 Emphysema distribution in smoking; BRCA cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg23649088 chr2:200775458 C2orf69 -0.61 -7.95 -0.3 8.5e-15 Schizophrenia; BRCA cis rs7301826 0.585 rs6486600 chr12:131292977 C/T cg11011512 chr12:131303247 STX2 0.47 12.11 0.43 1.56e-30 Plasma plasminogen activator levels; BRCA cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg01689657 chr7:91764605 CYP51A1 -0.24 -8.41 -0.32 2.62e-16 Breast cancer; BRCA cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.31 8.4 0.32 2.97e-16 Birth weight; BRCA cis rs9308433 0.529 rs11120298 chr1:214500620 A/G cg06198575 chr1:214491504 SMYD2 0.57 12.44 0.44 5.68e-32 IgG glycosylation; BRCA cis rs7264396 0.790 rs6060565 chr20:34285442 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -16.0 -0.53 1.08e-48 Total cholesterol levels; BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg08888203 chr3:10149979 C3orf24 0.56 11.44 0.41 1.05e-27 Alzheimer's disease; BRCA cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg06784218 chr1:46089804 CCDC17 -0.5 -11.84 -0.42 2.31e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs9287719 0.935 rs7600495 chr2:10739800 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs11719291 0.833 rs13074318 chr3:48816725 C/T cg00383909 chr3:49044727 WDR6 0.97 15.45 0.52 5.37e-46 Cognitive function; BRCA trans rs12517041 1.000 rs1366452 chr5:23279222 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA cis rs6772849 0.931 rs60825080 chr3:128384834 G/T cg16766828 chr3:128327626 NA -0.41 -8.9 -0.33 5.75e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.57 11.96 0.43 6.77e-30 Age-related macular degeneration (geographic atrophy); BRCA cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg03433033 chr1:76189801 ACADM 0.73 18.51 0.59 1.47e-61 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs909002 0.849 rs2271933 chr1:32092525 C/T cg11573219 chr1:32083031 HCRTR1 -0.26 -8.2 -0.31 1.36e-15 Intelligence (multi-trait analysis); BRCA cis rs365132 0.967 rs58279426 chr5:176448139 T/C cg16309518 chr5:176445507 NA -0.51 -12.94 -0.46 3.54e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs11051970 0.879 rs2651378 chr12:32581794 A/G cg02745156 chr12:32552066 NA 0.27 8.93 0.33 4.43e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs61931739 0.534 rs1843733 chr12:34047626 T/C cg06521331 chr12:34319734 NA -0.58 -11.65 -0.42 1.47e-28 Morning vs. evening chronotype; BRCA cis rs17095355 1.000 rs55781439 chr10:111670220 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.0 -0.37 5.84e-22 Biliary atresia; BRCA cis rs7249142 0.549 rs539 chr19:19287802 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.4 -0.32 3e-16 IgG glycosylation; BRCA cis rs4409675 0.576 rs6598912 chr1:28233289 C/T cg23691781 chr1:28212827 C1orf38 0.32 10.43 0.38 1.29e-23 Corneal astigmatism; BRCA cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg07395648 chr5:131743802 NA -0.37 -9.14 -0.34 7.96e-19 Blood metabolite levels; BRCA cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg04267008 chr7:1944627 MAD1L1 -0.49 -10.79 -0.39 4.6e-25 Bipolar disorder and schizophrenia; BRCA cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.43e-36 High light scatter reticulocyte count; BRCA cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg18305652 chr10:134549665 INPP5A -0.5 -12.66 -0.45 6.37e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg18132916 chr6:79620363 NA -0.48 -10.82 -0.39 3.65e-25 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 20.09 0.62 5.9e-70 Platelet count; BRCA cis rs2625529 0.824 rs16956452 chr15:72284092 T/C cg16672083 chr15:72433130 SENP8 -0.85 -17.66 -0.57 4.05e-57 Red blood cell count; BRCA trans rs9858542 0.953 rs7648841 chr3:49416825 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.24 -0.34 3.51e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg10295955 chr4:187884368 NA -1.0 -31.58 -0.78 1.35e-132 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg17971929 chr21:40555470 PSMG1 0.77 18.12 0.58 1.53e-59 Cognitive function; BRCA cis rs9420 0.961 rs11229131 chr11:57562525 G/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.55 -0.44 1.96e-32 Schizophrenia; BRCA cis rs8180040 0.726 rs4078466 chr3:47126543 C/T cg16586182 chr3:47516702 SCAP -0.57 -13.01 -0.46 1.66e-34 Colorectal cancer; BRCA cis rs34779708 0.931 rs2384289 chr10:35343525 G/A cg03585969 chr10:35415529 CREM 0.45 9.51 0.35 3.94e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs250677 0.687 rs185155 chr5:148455893 T/C cg18129178 chr5:148520854 ABLIM3 -0.59 -12.03 -0.43 3.56e-30 Breast cancer; BRCA cis rs4478858 0.735 rs1566964 chr1:31792794 C/A cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.1e-16 Alcohol dependence; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg04013093 chr6:42928303 GNMT -0.27 -8.54 -0.32 9.68e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg26384229 chr12:38710491 ALG10B 0.77 17.62 0.57 6.36e-57 Drug-induced liver injury (flucloxacillin); BRCA trans rs35110281 0.600 rs11089092 chr21:45120994 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.7 0.33 2.81e-17 Mean corpuscular volume; BRCA cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs7011049 1.000 rs11997775 chr8:53833571 C/T cg26025543 chr8:53854495 NA -0.49 -9.46 -0.35 6.03e-20 Systolic blood pressure; BRCA trans rs61332075 0.518 rs112649209 chr2:239422814 C/G cg01134436 chr17:81009848 B3GNTL1 0.69 8.91 0.33 5.13e-18 Lung function (FEV1/FVC); BRCA cis rs2011503 1.000 rs34667451 chr19:19617017 C/T cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10949834 0.730 rs2237503 chr7:73509326 G/C cg07137043 chr7:73588983 EIF4H -0.51 -7.92 -0.3 1.06e-14 Verbal memory performance (residualized delayed recall change); BRCA cis rs12369635 1.000 rs12369635 chr12:129561356 C/T cg01909103 chr12:129572610 TMEM132D -0.69 -7.85 -0.3 1.73e-14 Schizophrenia (inflammation and infection response interaction); BRCA cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg03433033 chr1:76189801 ACADM -0.59 -11.68 -0.42 1.03e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.6 -0.32 6.33e-17 Developmental language disorder (linguistic errors); BRCA cis rs3771570 1.000 rs4675811 chr2:242402062 A/T cg21155796 chr2:242212141 HDLBP 0.51 8.86 0.33 8.03e-18 Prostate cancer; BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg27170947 chr2:26402098 FAM59B 0.77 11.03 0.4 5.15e-26 Gut microbiome composition (summer); BRCA cis rs7264396 0.563 rs2425071 chr20:34292961 A/C cg04508476 chr20:34239394 CPNE1;RBM12 0.66 11.74 0.42 6.17e-29 Total cholesterol levels; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -9.16 -0.34 7.13e-19 Bipolar disorder; BRCA cis rs1448094 0.512 rs7299285 chr12:86244959 A/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.28 -0.34 2.49e-19 Major depressive disorder; BRCA cis rs9457247 0.602 rs4710175 chr6:167467800 A/G cg07741184 chr6:167504864 NA 0.37 10.82 0.39 3.6e-25 Crohn's disease; BRCA cis rs41005 0.967 rs6752776 chr2:8104594 A/G cg03155496 chr2:8117019 LOC339788 0.54 14.32 0.49 1.58e-40 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg19077165 chr18:44547161 KATNAL2 -0.53 -11.35 -0.41 2.48e-27 Personality dimensions; BRCA cis rs853679 0.517 rs9380050 chr6:28048538 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.15e-15 Depression; BRCA cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg20701182 chr2:24300061 SF3B14 0.66 9.7 0.36 7.36e-21 Lymphocyte counts; BRCA cis rs7584330 0.554 rs880931 chr2:238396741 G/A cg14458575 chr2:238380390 NA 0.53 8.5 0.32 1.31e-16 Prostate cancer; BRCA cis rs3617 0.625 rs3774364 chr3:52863605 G/A cg11645453 chr3:52864694 ITIH4 0.32 8.28 0.31 7.28e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs12472274 0.648 rs67102443 chr2:239084602 A/G cg17459225 chr2:239074497 NA 0.42 9.07 0.34 1.43e-18 Phospholipid levels (plasma); BRCA cis rs2204008 0.728 rs12369538 chr12:38443942 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.72 0.36 6.47e-21 Bladder cancer; BRCA cis rs1371867 0.846 rs1660327 chr8:101292206 A/C cg06636551 chr8:101224915 SPAG1 -0.38 -8.62 -0.32 5.27e-17 Atrioventricular conduction; BRCA cis rs6752107 0.967 rs11694081 chr2:234148586 A/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 10.65 0.39 1.78e-24 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg26446133 chr18:72167187 CNDP2 -0.79 -19.95 -0.62 3.38e-69 Refractive error; BRCA cis rs13046373 0.508 rs1507393 chr21:31992779 A/G cg16812893 chr21:31813075 KRTAP15-1 0.37 9.25 0.34 3.32e-19 HDL cholesterol; BRCA cis rs10181042 0.565 rs1177233 chr2:61262134 C/T cg15711740 chr2:61764176 XPO1 0.37 8.57 0.32 7.92e-17 Crohn's disease; BRCA cis rs4363385 0.818 rs454993 chr1:153008992 C/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.14 0.46 4.34e-35 Bipolar disorder; BRCA cis rs12545109 0.800 rs1837614 chr8:57414497 T/A cg09654669 chr8:57350985 NA -0.39 -8.4 -0.32 2.82e-16 Obesity-related traits; BRCA cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg18200150 chr17:30822561 MYO1D -0.37 -9.19 -0.34 5.26e-19 Schizophrenia; BRCA cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg15595755 chr5:1867978 NA 0.36 8.46 0.32 1.81e-16 Cardiovascular disease risk factors; BRCA cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg10802521 chr3:52805072 NEK4 -0.33 -8.53 -0.32 1.04e-16 Bipolar disorder; BRCA cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11644478 chr21:40555479 PSMG1 -0.54 -11.54 -0.42 3.92e-28 Menarche (age at onset); BRCA cis rs9790314 0.696 rs9290069 chr3:160890946 A/G cg03342759 chr3:160939853 NMD3 -0.54 -11.6 -0.42 2.33e-28 Morning vs. evening chronotype; BRCA cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 13.59 0.47 3.9e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11644478 chr21:40555479 PSMG1 0.65 14.61 0.5 6.15e-42 Cognitive function; BRCA cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs698833 0.926 rs786407 chr2:44735865 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.04 0.37 4.11e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs8062405 1.000 rs62037371 chr16:28890131 C/A cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs965469 1.000 rs6037551 chr20:3306690 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -10.68 -0.39 1.32e-24 IFN-related cytopenia; BRCA cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg12373951 chr3:133503437 NA 0.53 12.48 0.44 3.98e-32 Iron status biomarkers; BRCA cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg26769984 chr7:1090371 C7orf50 0.69 13.39 0.47 3.22e-36 Bronchopulmonary dysplasia; BRCA cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg20701182 chr2:24300061 SF3B14 0.71 13.2 0.46 2.33e-35 Lymphocyte counts; BRCA cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg26597838 chr10:835615 NA 0.95 14.42 0.5 5.19e-41 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.36 0.38 2.26e-23 Motion sickness; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg13047869 chr3:10149882 C3orf24 0.6 12.74 0.45 2.67e-33 Alzheimer's disease; BRCA trans rs2204008 0.692 rs11613378 chr12:38213138 T/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs2766692 0.956 rs35696661 chr14:100742355 G/C cg14866419 chr14:100704911 YY1 0.44 9.31 0.35 1.99e-19 Electroencephalographic traits in alcoholism; BRCA cis rs9427116 0.677 rs9426831 chr1:154609657 A/T cg17218026 chr1:154582156 ADAR -0.28 -7.9 -0.3 1.18e-14 Blood protein levels; BRCA cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg12751644 chr20:60527061 NA -0.33 -7.95 -0.3 8.44e-15 Body mass index; BRCA cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg23711669 chr6:146136114 FBXO30 0.8 18.81 0.6 3.7e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs6815814 0.950 rs73236615 chr4:38786869 G/T cg06935464 chr4:38784597 TLR10 0.51 8.96 0.33 3.43e-18 Breast cancer; BRCA cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg23711669 chr6:146136114 FBXO30 0.74 16.82 0.55 7.41e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs9316337 1.000 rs9316337 chr13:21962207 C/T cg21011702 chr13:21951294 ZDHHC20 -0.32 -8.2 -0.31 1.31e-15 Schizophrenia; BRCA cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg06115741 chr20:33292138 TP53INP2 0.49 11.08 0.4 3.37e-26 Coronary artery disease; BRCA trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.09 0.3 3.09e-15 Corneal astigmatism; BRCA cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.51 0.32 1.21e-16 Rheumatoid arthritis; BRCA cis rs7819412 0.668 rs2409721 chr8:11038244 A/T cg21775007 chr8:11205619 TDH -0.46 -8.86 -0.33 7.62e-18 Triglycerides; BRCA cis rs4595586 0.525 rs17467376 chr12:39377551 T/G cg26384229 chr12:38710491 ALG10B 0.55 11.69 0.42 9.73e-29 Morning vs. evening chronotype; BRCA cis rs96067 0.805 rs6425966 chr1:36611287 C/T cg24686825 chr1:36642396 MAP7D1 0.5 9.17 0.34 6.64e-19 Corneal structure; BRCA cis rs796364 0.664 rs4673660 chr2:200915395 C/T cg23649088 chr2:200775458 C2orf69 0.57 9.53 0.35 3.32e-20 Schizophrenia; BRCA cis rs11583043 0.872 rs1326380 chr1:101293753 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.41 8.4 0.32 2.94e-16 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs250677 0.687 rs36044 chr5:148441128 T/C cg23229984 chr5:148520753 ABLIM3 0.36 8.89 0.33 6.37e-18 Breast cancer; BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.63 -0.42 1.74e-28 Gut microbiome composition (summer); BRCA cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.62 0.39 2.33e-24 Bipolar disorder; BRCA cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg11752832 chr7:134001865 SLC35B4 0.5 12.74 0.45 2.81e-33 Mean platelet volume; BRCA cis rs72627509 0.904 rs17081933 chr4:57822869 T/A cg26694713 chr4:57773883 REST 0.48 9.05 0.34 1.69e-18 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9486719 0.895 rs12190520 chr6:96928620 A/C cg06623918 chr6:96969491 KIAA0776 -0.73 -13.15 -0.46 3.89e-35 Migraine;Coronary artery disease; BRCA cis rs11190604 1.000 rs11190558 chr10:102209397 C/A cg07080220 chr10:102295463 HIF1AN 0.49 11.33 0.41 2.98e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9359856 0.623 rs1179906 chr6:90323624 T/C cg13799429 chr6:90582589 CASP8AP2 -0.53 -8.66 -0.32 3.9e-17 Bipolar disorder; BRCA cis rs9807989 0.507 rs4851571 chr2:103019000 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.49 0.32 1.49e-16 Asthma; BRCA cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg11764359 chr7:65958608 NA -0.74 -16.31 -0.54 3.11e-50 Aortic root size; BRCA cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg02574844 chr11:5959923 NA -0.42 -8.76 -0.33 1.79e-17 DNA methylation (variation); BRCA cis rs6547741 0.935 rs6761095 chr2:27778010 G/T cg27432699 chr2:27873401 GPN1 0.47 9.83 0.36 2.46e-21 Oral cavity cancer; BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00908189 chr16:619842 PIGQ 0.7 18.32 0.59 1.5e-60 Height; BRCA cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg08999081 chr20:33150536 PIGU 0.47 12.95 0.46 3.17e-34 Glomerular filtration rate (creatinine); BRCA trans rs4332037 0.539 rs11763750 chr7:2080114 G/A cg11693508 chr17:37793320 STARD3 0.58 10.72 0.39 9.07e-25 Bipolar disorder; BRCA cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs6665290 0.935 rs12409755 chr1:227196949 A/T cg10327440 chr1:227177885 CDC42BPA -1.16 -49.12 -0.89 3.85e-219 Myeloid white cell count; BRCA cis rs7246657 1.000 rs1823061 chr19:37800626 G/A cg18154014 chr19:37997991 ZNF793 0.53 9.99 0.37 6.38e-22 Coronary artery calcification; BRCA trans rs877282 0.853 rs11593836 chr10:756715 G/A cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg19077165 chr18:44547161 KATNAL2 -0.53 -11.34 -0.41 2.79e-27 Personality dimensions; BRCA cis rs7617773 0.815 rs6793150 chr3:48351560 G/A cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -9.22 -0.34 4.33e-19 Personality dimensions; BRCA cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg13736514 chr6:26305472 NA -0.35 -11.82 -0.42 2.62e-29 Educational attainment; BRCA cis rs754466 0.914 rs12219971 chr10:79701526 T/C cg17075019 chr10:79541650 NA -0.64 -12.18 -0.43 7.91e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg16479474 chr6:28041457 NA 0.42 7.82 0.3 2.18e-14 Parkinson's disease; BRCA cis rs919433 0.680 rs2564389 chr2:198260098 A/T cg00792783 chr2:198669748 PLCL1 0.38 8.66 0.32 3.94e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11890956 chr21:40555474 PSMG1 -0.82 -20.51 -0.63 3.3e-72 Cognitive function; BRCA cis rs1691799 0.899 rs903587 chr12:66746061 C/A cg16791601 chr12:66731901 HELB -0.69 -19.55 -0.61 4.29e-67 White blood cell count (basophil); BRCA cis rs6599636 1 rs6599636 chr10:124677899 T/G cg05252487 chr10:124670562 FAM24A -0.32 -8.08 -0.3 3.28e-15 Red cell distribution width; BRCA cis rs7296418 0.961 rs4148862 chr12:123568619 A/C cg00376283 chr12:123451042 ABCB9 0.58 15.19 0.51 1.07e-44 Platelet count; BRCA cis rs72799341 1.000 rs7200879 chr16:30947572 A/G cg02466173 chr16:30829666 NA -0.47 -8.56 -0.32 8.2e-17 Diastolic blood pressure; BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg03709012 chr19:19516395 GATAD2A 0.72 15.81 0.53 9.57e-48 Tonsillectomy; BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg09177884 chr7:1199841 ZFAND2A -0.41 -9.32 -0.35 1.86e-19 Longevity;Endometriosis; BRCA cis rs13046373 0.535 rs1605428 chr21:32028976 T/C cg14062083 chr21:31802829 KRTAP13-4 0.35 9.29 0.34 2.47e-19 HDL cholesterol; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 18.05 0.58 3.74e-59 Platelet count; BRCA cis rs2282802 0.685 rs35214989 chr5:139636127 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.18 0.31 1.51e-15 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.28 0.34 2.56e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs3617 0.625 rs2071042 chr3:52864584 A/G cg11645453 chr3:52864694 ITIH4 0.38 10.07 0.37 3.03e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg08975724 chr8:8085496 FLJ10661 -0.41 -8.85 -0.33 8.44e-18 Mood instability; BRCA trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg23533926 chr12:111358616 MYL2 -0.43 -9.14 -0.34 8.32e-19 Extrinsic epigenetic age acceleration; BRCA cis rs1577917 0.917 rs35283633 chr6:86690787 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -7.92 -0.3 1.06e-14 Response to antipsychotic treatment; BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg21782813 chr7:2030301 MAD1L1 0.33 9.05 0.34 1.76e-18 Schizophrenia; BRCA cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.65 0.42 1.45e-28 Mean platelet volume; BRCA cis rs9790314 0.846 rs4470535 chr3:160974468 G/A cg04691961 chr3:161091175 C3orf57 -0.45 -10.81 -0.39 4.13e-25 Morning vs. evening chronotype; BRCA cis rs870825 0.616 rs7660939 chr4:185640792 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.18 0.56 1.08e-54 Blood protein levels; BRCA cis rs1865760 0.568 rs2032450 chr6:25993114 C/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.59 0.39 2.96e-24 Height; BRCA trans rs7824557 0.767 rs1897950 chr8:11169551 C/A cg08975724 chr8:8085496 FLJ10661 0.43 8.0 0.3 5.82e-15 Retinal vascular caliber; BRCA cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg00701064 chr4:6280414 WFS1 0.68 17.7 0.57 2.54e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1448094 0.717 rs7137122 chr12:86290702 T/C cg19622623 chr12:86230825 RASSF9 -0.28 -8.08 -0.3 3.17e-15 Major depressive disorder; BRCA cis rs72781680 1.000 rs72781632 chr2:24198342 A/C cg08917208 chr2:24149416 ATAD2B 1.1 15.63 0.53 7.08e-47 Lymphocyte counts; BRCA cis rs10782582 0.593 rs12131344 chr1:76136437 C/T cg03433033 chr1:76189801 ACADM -0.46 -9.42 -0.35 8.36e-20 Daytime sleep phenotypes; BRCA cis rs950776 0.720 rs11637890 chr15:78935419 C/G cg06917634 chr15:78832804 PSMA4 -0.52 -10.19 -0.37 1.03e-22 Sudden cardiac arrest; BRCA cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg05729581 chr11:3078854 CARS -0.36 -8.86 -0.33 7.97e-18 Longevity; BRCA cis rs861020 0.959 rs658860 chr1:209990549 C/T cg05527609 chr1:210001259 C1orf107 0.69 15.0 0.51 8.45e-44 Orofacial clefts; BRCA cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.9e-19 Lymphocyte counts; BRCA cis rs12579753 1.000 rs11613196 chr12:82173251 A/T cg07988820 chr12:82153109 PPFIA2 0.59 9.64 0.36 1.26e-20 Resting heart rate; BRCA cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.81e-18 Bone mineral density; BRCA cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.88e-41 Motion sickness; BRCA cis rs3008870 0.709 rs62883160 chr1:67392889 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.58 0.47 4.23e-37 Lymphocyte percentage of white cells; BRCA cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg11644478 chr21:40555479 PSMG1 -0.66 -14.65 -0.5 4.24e-42 Cognitive function; BRCA cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg23711669 chr6:146136114 FBXO30 0.74 16.99 0.56 1.09e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs6901250 0.851 rs339360 chr6:117160872 G/T cg12892004 chr6:117198278 RFX6 -0.5 -11.55 -0.42 3.85e-28 C-reactive protein levels; BRCA trans rs11098499 0.954 rs3733520 chr4:120423480 C/G cg25214090 chr10:38739885 LOC399744 0.52 11.9 0.43 1.24e-29 Corneal astigmatism; BRCA cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.68e-16 Putamen volume; BRCA cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg10978503 chr1:24200527 CNR2 0.47 12.16 0.43 9.86e-31 Immature fraction of reticulocytes; BRCA cis rs11190604 1.000 rs11816840 chr10:102309220 G/C cg07080220 chr10:102295463 HIF1AN 0.65 15.11 0.51 2.53e-44 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg12311346 chr5:56204834 C5orf35 -0.8 -16.01 -0.54 9.43e-49 Initial pursuit acceleration; BRCA cis rs10716631 1 rs10716631 chr2:219138170 T/G cg20019365 chr2:219134978 PNKD;AAMP 0.6 13.38 0.47 3.74e-36 High light scatter reticulocyte percentage of red cells;Plateletcrit; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.89 -0.33 6.07e-18 Total body bone mineral density; BRCA cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg08704250 chr15:31115839 NA 0.34 8.81 0.33 1.22e-17 Huntington's disease progression; BRCA cis rs11711311 1.000 rs9879760 chr3:113457948 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 9.17 0.34 6.48e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2797160 1.000 rs4895798 chr6:126000162 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.41 -0.35 9.06e-20 Endometrial cancer; BRCA cis rs7927771 0.524 rs4752796 chr11:47841862 A/G cg20307385 chr11:47447363 PSMC3 -0.4 -9.5 -0.35 4.26e-20 Subjective well-being; BRCA cis rs698833 0.886 rs4953087 chr2:44561627 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.11 0.37 2.15e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs701145 0.585 rs1713798 chr3:153807407 G/A cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -9.08 -0.34 1.32e-18 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg02675527 chr2:114030824 PAX8;LOC440839 0.44 10.25 0.38 6.04e-23 Lymphocyte counts; BRCA cis rs7255436 0.965 rs11666003 chr19:8452102 G/A cg10174797 chr19:8464628 RAB11B 0.35 9.01 0.34 2.41e-18 HDL cholesterol; BRCA cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg13736514 chr6:26305472 NA -0.35 -11.82 -0.42 2.62e-29 Educational attainment; BRCA cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg08213375 chr14:104286397 PPP1R13B 0.41 8.83 0.33 1.02e-17 Reticulocyte count; BRCA cis rs4892230 1 rs4892230 chr18:72155572 G/A cg25817165 chr18:72167213 CNDP2 -0.5 -10.9 -0.4 1.7e-25 Mononucleosis; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg23285459 chr7:2802560 GNA12 -0.39 -9.86 -0.36 1.97e-21 Height; BRCA cis rs2882667 0.898 rs11956089 chr5:138394604 G/T cg04439458 chr5:138467593 SIL1 0.33 8.96 0.33 3.66e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs350251 0.934 rs350210 chr16:12212689 T/G cg06014057 chr16:12226852 SNX29 0.3 7.87 0.3 1.48e-14 Intelligence (multi-trait analysis); BRCA cis rs694739 1.000 rs499425 chr11:64105929 A/G cg26898376 chr11:64110657 CCDC88B -0.39 -8.36 -0.31 3.92e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg11822812 chr5:140052017 DND1 -0.3 -8.27 -0.31 8e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs17021463 0.902 rs13102926 chr4:95245527 C/T cg11021082 chr4:95130006 SMARCAD1 0.38 8.03 0.3 4.72e-15 Testicular germ cell tumor; BRCA cis rs7474896 0.559 rs1024202 chr10:38278977 A/C cg25427524 chr10:38739819 LOC399744 0.54 9.63 0.36 1.4e-20 Obesity (extreme); BRCA cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 8.69 0.32 3.15e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg08000102 chr2:233561755 GIGYF2 0.62 13.68 0.48 1.58e-37 Coronary artery disease; BRCA cis rs8017423 0.647 rs12883844 chr14:90820519 T/C cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg27489772 chr12:121021490 NA 0.44 7.95 0.3 8.41e-15 Type 1 diabetes nephropathy; BRCA cis rs1707322 1.000 rs4460583 chr1:46449918 C/G cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.69 0.36 8.18e-21 Bipolar disorder; BRCA cis rs4808199 0.948 rs7259434 chr19:19428805 A/T cg01262667 chr19:19385393 TM6SF2 0.38 8.23 0.31 1.09e-15 Nonalcoholic fatty liver disease; BRCA cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs11723261 0.621 rs7440274 chr4:155713 C/T cg12746427 chr4:53362 ZNF718;ZNF595 -0.36 -7.86 -0.3 1.59e-14 Immune response to smallpox vaccine (IL-6); BRCA cis rs3812049 0.826 rs6860245 chr5:127367998 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.59 -11.19 -0.4 1.15e-26 Lymphocyte counts;Red cell distribution width; BRCA cis rs10242455 0.702 rs45448997 chr7:99041598 G/C cg18809830 chr7:99032528 PTCD1 -0.63 -8.98 -0.33 3.13e-18 Blood metabolite levels; BRCA cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.65 -11.98 -0.43 5.7e-30 Chronic sinus infection; BRCA cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -13.52 -0.47 7.81e-37 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs3892630 1.000 rs3892630 chr19:33181484 A/G cg22980127 chr19:33182716 NUDT19 -0.9 -18.46 -0.59 2.68e-61 Red blood cell traits; BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg21724239 chr8:58056113 NA 0.63 9.8 0.36 3.32e-21 Developmental language disorder (linguistic errors); BRCA trans rs66887589 0.934 rs6817317 chr4:120542827 A/G cg25214090 chr10:38739885 LOC399744 -0.34 -7.85 -0.3 1.72e-14 Diastolic blood pressure; BRCA cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.12 -0.37 1.97e-22 Initial pursuit acceleration; BRCA cis rs12210905 0.688 rs12374649 chr6:27343726 C/T cg08851530 chr6:28072375 NA 0.84 8.07 0.3 3.48e-15 Hip circumference adjusted for BMI; BRCA cis rs4845875 0.626 rs10779764 chr1:11832311 G/C cg24844545 chr1:11908347 NPPA 0.31 7.85 0.3 1.78e-14 Midregional pro atrial natriuretic peptide levels; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.37 -7.99 -0.3 6.32e-15 Longevity;Endometriosis; BRCA cis rs679087 0.932 rs721617 chr12:29934586 C/T cg14258853 chr12:29935411 TMTC1 0.4 8.92 0.33 4.99e-18 Schizophrenia; BRCA trans rs637571 0.546 rs10791827 chr11:65596546 C/A cg17712092 chr4:129076599 LARP1B -0.54 -12.43 -0.44 6.53e-32 Eosinophil percentage of white cells; BRCA cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.91 -0.33 5.22e-18 Alzheimer's disease (late onset); BRCA cis rs10751667 0.643 rs7479473 chr11:929111 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.01 -0.43 4.17e-30 Alzheimer's disease; BRCA cis rs17253792 0.822 rs17683656 chr14:56053361 C/T cg01858014 chr14:56050164 KTN1 0.77 10.98 0.4 8.52e-26 Putamen volume; BRCA cis rs2806561 0.754 rs648322 chr1:23294839 C/T cg19743168 chr1:23544995 NA 0.38 9.29 0.34 2.47e-19 Height; BRCA cis rs250677 0.522 rs10045726 chr5:148352990 C/T cg12140854 chr5:148520817 ABLIM3 0.41 8.46 0.32 1.83e-16 Breast cancer; BRCA cis rs34779708 0.931 rs34954932 chr10:35410807 G/T cg03585969 chr10:35415529 CREM 0.47 10.03 0.37 4.46e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg21782813 chr7:2030301 MAD1L1 0.38 10.19 0.37 1.07e-22 Bipolar disorder and schizophrenia; BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.61 -11.5 -0.41 5.94e-28 Gut microbiome composition (summer); BRCA cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg12373951 chr3:133503437 NA 0.45 10.61 0.39 2.43e-24 Iron status biomarkers; BRCA trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21659725 chr3:3221576 CRBN -0.49 -12.59 -0.45 1.28e-32 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg11764359 chr7:65958608 NA 0.76 16.6 0.55 1.05e-51 Aortic root size; BRCA cis rs79839061 0.520 rs11730111 chr4:942833 C/T cg07828340 chr4:882639 GAK 0.96 11.41 0.41 1.46e-27 Intelligence (multi-trait analysis); BRCA cis rs3768617 0.782 rs12143211 chr1:182990172 C/G ch.1.3577855R chr1:183094577 LAMC1 0.47 10.17 0.37 1.31e-22 Fuchs's corneal dystrophy; BRCA cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg02544614 chr20:61657117 NA 0.29 8.19 0.31 1.44e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg05347473 chr6:146136440 FBXO30 0.4 7.93 0.3 9.88e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3858526 0.584 rs10769270 chr11:5860563 T/C cg02574844 chr11:5959923 NA -0.4 -8.22 -0.31 1.11e-15 DNA methylation (variation); BRCA cis rs13401104 0.587 rs6431443 chr2:237150311 T/C cg19324714 chr2:237145437 ASB18 0.38 7.86 0.3 1.65e-14 Educational attainment; BRCA cis rs17376456 0.877 rs12153501 chr5:93360866 T/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.0 0.3 6.07e-15 Diabetic retinopathy; BRCA cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg04455712 chr21:45112962 RRP1B 0.4 10.5 0.38 6.75e-24 Mean corpuscular volume; BRCA cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -10.87 -0.39 2.32e-25 IgG glycosylation; BRCA cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg04553112 chr3:125709451 NA -0.55 -8.77 -0.33 1.57e-17 Blood pressure (smoking interaction); BRCA cis rs7927771 1.000 rs10838738 chr11:47663049 A/G cg18512352 chr11:47633146 NA -0.37 -8.84 -0.33 9.5e-18 Subjective well-being; BRCA cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg24296786 chr1:45957014 TESK2 0.62 15.49 0.52 3.48e-46 High light scatter reticulocyte count; BRCA cis rs28669119 0.841 rs10044342 chr5:88178683 C/T cg18498987 chr5:88179539 MEF2C -0.42 -8.08 -0.3 3.13e-15 Schizophrenia; BRCA cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg13010199 chr12:38710504 ALG10B 0.55 12.21 0.43 5.87e-31 Heart rate; BRCA cis rs172166 0.652 rs476167 chr6:28065888 T/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.39 0.32 3.09e-16 Cardiac Troponin-T levels; BRCA cis rs2832077 0.506 rs10222093 chr21:30163518 T/C cg24692254 chr21:30365293 RNF160 -0.46 -9.93 -0.37 1.02e-21 Cognitive test performance; BRCA cis rs17253792 0.822 rs77033617 chr14:56129746 T/A cg01858014 chr14:56050164 KTN1 -0.74 -9.16 -0.34 7.15e-19 Putamen volume; BRCA cis rs7572263 0.959 rs7583625 chr2:209048739 A/G cg23998903 chr2:209048830 C2orf80 -0.32 -8.11 -0.31 2.63e-15 Glioma;Non-glioblastoma glioma; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18402987 chr7:1209562 NA 0.61 13.06 0.46 1.05e-34 Longevity;Endometriosis; BRCA cis rs11676348 0.846 rs4674260 chr2:219002376 T/C cg00012203 chr2:219082015 ARPC2 -0.42 -8.14 -0.31 2.12e-15 Ulcerative colitis; BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg16606324 chr3:10149918 C3orf24 0.46 7.95 0.3 8.24e-15 Alzheimer's disease; BRCA cis rs9880211 1.000 rs9826454 chr3:135953220 A/G cg21827317 chr3:136751795 NA -0.43 -7.87 -0.3 1.55e-14 Body mass index;Height; BRCA cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg00152838 chr16:24741724 TNRC6A -0.35 -7.98 -0.3 7.04e-15 Intelligence (multi-trait analysis); BRCA cis rs6456156 0.586 rs10946208 chr6:167459596 C/T cg07741184 chr6:167504864 NA 0.34 10.11 0.37 2.23e-22 Primary biliary cholangitis; BRCA cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.29e-36 Mean platelet volume; BRCA cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg23029597 chr12:123009494 RSRC2 -0.6 -12.31 -0.44 2.21e-31 Body mass index; BRCA cis rs2652834 0.808 rs11071723 chr15:63355275 A/T cg05507819 chr15:63340323 TPM1 0.53 9.25 0.34 3.23e-19 HDL cholesterol; BRCA cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg22974920 chr21:40686053 BRWD1 -0.39 -8.79 -0.33 1.34e-17 Cognitive function; BRCA cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.01 15.23 0.52 6.41e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2933343 0.679 rs1091938 chr3:128637025 T/C cg25356066 chr3:128598488 ACAD9 0.36 8.39 0.32 3.1e-16 IgG glycosylation; BRCA cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg03453431 chr7:157225567 NA -0.48 -9.78 -0.36 3.94e-21 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA trans rs66887589 0.807 rs7694483 chr4:120405929 T/A cg25214090 chr10:38739885 LOC399744 0.35 7.98 0.3 6.75e-15 Diastolic blood pressure; BRCA trans rs1459104 0.929 rs2017467 chr11:55234605 G/A cg15704280 chr7:45808275 SEPT13 0.67 8.35 0.31 4.13e-16 Body mass index; BRCA cis rs7677751 0.708 rs2052699 chr4:55063994 C/T cg17187183 chr4:55093834 PDGFRA 0.4 8.14 0.31 2.01e-15 Corneal astigmatism; BRCA cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.03 0.34 2.08e-18 Motion sickness; BRCA cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg24088639 chr11:34937564 PDHX;APIP -0.4 -9.04 -0.34 1.8e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs877282 1.000 rs12779159 chr10:772143 T/C cg22713356 chr15:30763199 NA 1.3 26.04 0.72 1.81e-102 Uric acid levels; BRCA cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg22800045 chr5:56110881 MAP3K1 0.61 11.5 0.41 6.04e-28 Initial pursuit acceleration; BRCA cis rs7246657 0.653 rs10402050 chr19:37688958 A/T cg14683738 chr19:37701593 ZNF585B 0.54 8.19 0.31 1.4e-15 Coronary artery calcification; BRCA cis rs6446731 0.734 rs10937921 chr4:3276491 C/T cg08886695 chr4:3369023 RGS12 -0.34 -8.63 -0.32 5.01e-17 Mean platelet volume; BRCA trans rs2204008 0.677 rs1581356 chr12:38391467 T/C cg06521331 chr12:34319734 NA -0.45 -8.34 -0.31 4.44e-16 Bladder cancer; BRCA cis rs3771570 0.901 rs4675963 chr2:242324763 G/A cg21155796 chr2:242212141 HDLBP 0.47 8.22 0.31 1.1e-15 Prostate cancer; BRCA cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA cis rs6142102 0.923 rs4911383 chr20:32555779 A/G cg24642439 chr20:33292090 TP53INP2 0.43 7.97 0.3 7.52e-15 Skin pigmentation; BRCA cis rs208520 0.690 rs12198297 chr6:66714665 G/A cg07460842 chr6:66804631 NA 0.98 19.6 0.61 2.42e-67 Exhaled nitric oxide output; BRCA cis rs9486719 1.000 rs34209750 chr6:96882215 G/T cg06623918 chr6:96969491 KIAA0776 -0.73 -12.95 -0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs7766436 0.885 rs13198323 chr6:22577065 C/T cg13666174 chr6:22585274 NA -0.48 -11.17 -0.4 1.34e-26 Coronary artery disease; BRCA cis rs2073300 0.609 rs1076776 chr20:23427399 C/T cg12062639 chr20:23401060 NAPB -0.88 -12.83 -0.45 1.08e-33 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg20887711 chr4:1340912 KIAA1530 0.43 10.48 0.38 7.81e-24 Longevity; BRCA cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg13010199 chr12:38710504 ALG10B 0.45 9.59 0.35 1.8899999999999998e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs17376456 0.877 rs17083460 chr5:93462354 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.59 7.98 0.3 6.61e-15 Diabetic retinopathy; BRCA cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg20203395 chr5:56204925 C5orf35 -0.5 -10.02 -0.37 4.88e-22 Initial pursuit acceleration; BRCA cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg01475377 chr6:109611718 NA -0.6 -16.59 -0.55 1.15e-51 Reticulocyte fraction of red cells; BRCA cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg19717773 chr7:2847554 GNA12 -0.42 -9.37 -0.35 1.18e-19 Height; BRCA cis rs2066819 1.000 rs79718165 chr12:56644251 C/T cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs9467773 0.620 rs1027203 chr6:26639332 G/C cg09904177 chr6:26538194 HMGN4 0.43 12.65 0.45 6.53e-33 Intelligence (multi-trait analysis); BRCA cis rs921968 0.541 rs496674 chr2:219432569 G/A cg10223061 chr2:219282414 VIL1 -0.27 -8.03 -0.3 4.76e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs7254827 0.868 rs71338610 chr19:17210041 G/A cg19418318 chr19:17219073 MYO9B -0.51 -10.4 -0.38 1.69e-23 Mean platelet volume; BRCA trans rs2204008 0.744 rs11180504 chr12:38236313 C/T cg06521331 chr12:34319734 NA -0.49 -9.11 -0.34 1.06e-18 Bladder cancer; BRCA cis rs11190604 0.945 rs2495735 chr10:102338609 G/A cg07080220 chr10:102295463 HIF1AN 0.52 12.36 0.44 1.28e-31 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 7e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs561341 1.000 rs473356 chr17:30321762 G/C cg20587970 chr11:113659929 NA -1.24 -22.64 -0.67 8.57e-84 Hip circumference adjusted for BMI; BRCA cis rs7772486 0.764 rs2247211 chr6:146216379 G/A cg23711669 chr6:146136114 FBXO30 0.67 15.72 0.53 2.45e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs8017423 0.626 rs8003363 chr14:90826840 T/C cg04374321 chr14:90722782 PSMC1 -0.49 -11.68 -0.42 1.02e-28 Mortality in heart failure; BRCA cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg03433033 chr1:76189801 ACADM 0.73 18.86 0.6 2.17e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg09455208 chr3:40491958 NA -0.49 -10.91 -0.4 1.62e-25 Renal cell carcinoma; BRCA cis rs12618769 0.543 rs2278211 chr2:99149946 G/A cg10123293 chr2:99228465 UNC50 0.43 7.98 0.3 7.01e-15 Bipolar disorder; BRCA cis rs514406 0.505 rs269286 chr1:53169018 C/T cg16325326 chr1:53192061 ZYG11B -0.79 -22.16 -0.66 3.5e-81 Monocyte count; BRCA cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2430386 1.000 rs2430386 chr2:63178111 C/T cg17519650 chr2:63277830 OTX1 0.42 9.92 0.37 1.17e-21 Prostate cancer; BRCA cis rs13136331 0.641 rs2627685 chr4:88657792 T/C cg22416721 chr4:88570574 DMP1 -0.56 -13.49 -0.47 1.15e-36 Sitting height ratio; BRCA cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg21770322 chr7:97807741 LMTK2 0.42 11.3 0.41 4e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs6087771 0.890 rs6089056 chr20:30325773 A/G cg21427119 chr20:30132790 HM13 -0.35 -8.04 -0.3 4.42e-15 Subcortical brain region volumes;Putamen volume; BRCA cis rs11971779 0.680 rs6962637 chr7:139051350 G/A cg07862535 chr7:139043722 LUC7L2 0.38 10.31 0.38 3.76e-23 Diisocyanate-induced asthma; BRCA cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg22508957 chr16:3507546 NAT15 -0.46 -11.32 -0.41 3.21e-27 Tuberculosis; BRCA trans rs208520 0.661 rs1776361 chr6:66822270 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.02 -0.64 5.66e-75 Exhaled nitric oxide output; BRCA cis rs1401999 1.000 rs9858774 chr3:183652736 G/A cg20387954 chr3:183756860 HTR3D 0.45 10.11 0.37 2.13e-22 Anterior chamber depth; BRCA cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg24812749 chr6:127587940 RNF146 0.85 19.76 0.62 3.28e-68 Breast cancer; BRCA cis rs9341808 0.718 rs9443734 chr6:80820293 C/T cg08355045 chr6:80787529 NA 0.37 9.38 0.35 1.13e-19 Sitting height ratio; BRCA trans rs7746199 0.736 rs10484399 chr6:27534528 A/G cg01620082 chr3:125678407 NA -0.88 -10.15 -0.37 1.5e-22 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs9674544 0.757 rs4410130 chr17:47122942 C/T cg10950924 chr17:47092072 IGF2BP1 0.36 9.37 0.35 1.25e-19 Primary tooth development (time to first tooth eruption);Primary tooth development (number of teeth); BRCA cis rs2832077 0.527 rs2705690 chr21:30239245 T/A cg24692254 chr21:30365293 RNF160 0.5 11.32 0.41 3.3e-27 Cognitive test performance; BRCA cis rs8028182 0.609 rs10220738 chr15:75666546 A/T cg20655648 chr15:75932815 IMP3 -0.4 -7.83 -0.3 2.03e-14 Sudden cardiac arrest; BRCA cis rs218264 0.592 rs6840845 chr4:55366235 A/G cg17105814 chr4:55365203 NA 0.38 7.82 0.3 2.12e-14 Hemoglobin concentration;Hematocrit; BRCA cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.29 0.31 6.69e-16 Axial length; BRCA cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.84 18.62 0.59 3.9e-62 Smoking behavior; BRCA cis rs9290065 0.622 rs6797798 chr3:160646598 G/A cg03342759 chr3:160939853 NMD3 0.41 8.49 0.32 1.4e-16 Kawasaki disease; BRCA cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.43 -0.44 6.2e-32 Chronic sinus infection; BRCA cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.35 -12.81 -0.45 1.34e-33 Autism spectrum disorder or schizophrenia; BRCA cis rs7267979 0.706 rs6138542 chr20:25207773 C/A cg08601574 chr20:25228251 PYGB 0.4 9.36 0.35 1.35e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs61931739 0.534 rs11053021 chr12:34111157 C/T cg06521331 chr12:34319734 NA -0.61 -11.18 -0.4 1.2e-26 Morning vs. evening chronotype; BRCA cis rs936229 0.654 rs762551 chr15:75041917 C/A cg14664628 chr15:75095509 CSK -0.86 -22.99 -0.67 1.13e-85 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg22431228 chr1:16359049 CLCNKA 0.45 9.42 0.35 8.08e-20 Dilated cardiomyopathy; BRCA cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg19678392 chr7:94953810 PON1 -0.39 -8.05 -0.3 4.05e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs208515 0.560 rs207084 chr6:66776966 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.07 -32.55 -0.79 9.22e-138 Exhaled nitric oxide levels; BRCA cis rs4730250 0.634 rs257371 chr7:106795043 C/A cg02696742 chr7:106810147 HBP1 -0.58 -9.53 -0.35 3.32e-20 Osteoarthritis; BRCA trans rs8073060 0.586 rs2011897 chr17:34054408 A/T cg19694781 chr19:47549865 TMEM160 1.06 21.21 0.64 5.22e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21659725 chr3:3221576 CRBN -0.48 -10.32 -0.38 3.26e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4919694 0.611 rs76695159 chr10:105070837 C/T cg04362960 chr10:104952993 NT5C2 0.72 11.29 0.41 4.47e-27 Arsenic metabolism; BRCA cis rs897080 0.515 rs1067409 chr2:44673057 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.17 0.34 6.53e-19 Height; BRCA cis rs7394190 0.748 rs2292307 chr10:75549916 C/A cg07699608 chr10:75541558 CHCHD1 0.71 10.36 0.38 2.41e-23 Incident atrial fibrillation; BRCA cis rs6963495 0.818 rs73192126 chr7:105175415 T/C cg19920283 chr7:105172520 RINT1 0.59 9.53 0.35 3.29e-20 Bipolar disorder (body mass index interaction); BRCA cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg06115741 chr20:33292138 TP53INP2 0.5 11.31 0.41 3.64e-27 Coronary artery disease; BRCA cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg25703541 chr22:24373054 LOC391322 -0.49 -9.04 -0.34 1.92e-18 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.45 -10.14 -0.37 1.7e-22 Personality dimensions; BRCA cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.48 10.01 0.37 5.23e-22 Tonsillectomy; BRCA cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 9.84 0.36 2.37e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs2180341 0.842 rs9375492 chr6:127545492 C/T cg27446573 chr6:127587934 RNF146 -0.78 -15.52 -0.52 2.38e-46 Breast cancer; BRCA cis rs524281 0.861 rs10791855 chr11:65963737 A/G cg16950941 chr11:66035639 RAB1B -0.39 -8.37 -0.31 3.77e-16 Electroencephalogram traits; BRCA cis rs28830936 0.510 rs11858843 chr15:42092915 C/A cg17847044 chr15:42102381 MAPKBP1 -0.51 -19.45 -0.61 1.53e-66 Diastolic blood pressure; BRCA cis rs1003719 0.680 rs2187577 chr21:38533341 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.53 -0.5 1.55e-41 Eye color traits; BRCA cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg08470875 chr2:26401718 FAM59B -0.75 -12.08 -0.43 2.14e-30 Gut microbiome composition (summer); BRCA cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg16049864 chr8:95962084 TP53INP1 -0.44 -10.83 -0.39 3.3e-25 Type 2 diabetes; BRCA cis rs7577696 0.597 rs2280968 chr2:32290040 G/T cg02381751 chr2:32503542 YIPF4 -0.42 -8.01 -0.3 5.47e-15 Inflammatory biomarkers; BRCA cis rs8114671 0.562 rs6088621 chr20:33418740 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.26 0.34 3.02e-19 Height; BRCA cis rs752010 0.714 rs2148635 chr1:42082452 C/T cg06885757 chr1:42089581 HIVEP3 -0.28 -10.32 -0.38 3.37e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6484504 0.625 rs4922859 chr11:31382517 A/G cg14844989 chr11:31128820 NA 0.44 9.6 0.35 1.85e-20 Red blood cell count; BRCA cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg08085267 chr17:45401833 C17orf57 -0.59 -12.15 -0.43 1.07e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9811920 0.665 rs1872609 chr3:99906579 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -9.22 -0.34 4.35e-19 Axial length; BRCA cis rs10838687 0.736 rs1449626 chr11:47290759 A/C cg25783544 chr11:47291846 MADD 0.41 7.84 0.3 1.92e-14 Proinsulin levels; BRCA cis rs701145 0.585 rs1727882 chr3:153837246 C/T cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs13315871 0.929 rs77487951 chr3:58290892 G/A cg20936604 chr3:58311152 NA -0.67 -8.64 -0.32 4.35e-17 Cholesterol, total; BRCA cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg18132916 chr6:79620363 NA -0.48 -10.88 -0.4 2.14e-25 Intelligence (multi-trait analysis); BRCA cis rs1403694 0.695 rs13317089 chr3:186436217 G/C cg12454167 chr3:186435060 KNG1 0.29 7.94 0.3 9.4e-15 Blood protein levels; BRCA cis rs12611088 0.600 rs2355994 chr19:44005107 T/C cg15012607 chr19:44012195 ETHE1 -0.33 -7.98 -0.3 6.9e-15 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs6426558 0.537 rs694740 chr1:227293451 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 9.32 0.35 1.81e-19 Neutrophil percentage of white cells; BRCA cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg21132104 chr15:45694354 SPATA5L1 0.76 17.26 0.56 4.5e-55 Homoarginine levels; BRCA cis rs6545883 0.965 rs1992765 chr2:61751333 A/G cg15711740 chr2:61764176 XPO1 -0.54 -14.03 -0.49 3.53e-39 Tuberculosis; BRCA cis rs2415984 0.600 rs61993299 chr14:46944880 A/C cg14871534 chr14:47121158 RPL10L -0.32 -7.92 -0.3 1.09e-14 Number of children ever born; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg08132940 chr7:1081526 C7orf50 -0.47 -8.34 -0.31 4.69e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.27 -0.41 5.36e-27 IgG glycosylation; BRCA cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.36 8.11 0.31 2.67e-15 Schizophrenia; BRCA trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA cis rs7312933 0.703 rs10492388 chr12:42608001 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -9.14 -0.34 7.98e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg04025307 chr7:1156635 C7orf50 0.5 8.33 0.31 4.97e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg04450456 chr4:17643702 FAM184B -0.36 -10.39 -0.38 1.79e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1865760 0.516 rs9379818 chr6:26023206 G/T cg17691542 chr6:26056736 HIST1H1C 0.53 11.39 0.41 1.7e-27 Height; BRCA cis rs10504229 1.000 rs73607874 chr8:58173433 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg19729930 chr2:74357872 NA 0.58 14.23 0.49 4.2e-40 Gestational age at birth (maternal effect); BRCA cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg25427524 chr10:38739819 LOC399744 -0.59 -13.57 -0.47 4.76e-37 Extrinsic epigenetic age acceleration; BRCA cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg14019146 chr3:50243930 SLC38A3 -0.38 -9.2 -0.34 5.22e-19 Body mass index; BRCA cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg08213375 chr14:104286397 PPP1R13B 0.66 18.75 0.6 7.68e-63 Schizophrenia; BRCA cis rs11098499 0.863 rs11098532 chr4:120490726 C/A cg09307838 chr4:120376055 NA 0.69 13.95 0.48 8.36e-39 Corneal astigmatism; BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.11 0.34 1.06e-18 Platelet count; BRCA trans rs208520 0.802 rs4710315 chr6:66887594 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -18.32 -0.59 1.38e-60 Exhaled nitric oxide output; BRCA cis rs2309752 1 rs2309752 chr2:100762169 T/A cg22139774 chr2:100720529 AFF3 -0.31 -8.73 -0.33 2.26e-17 Intelligence (multi-trait analysis); BRCA cis rs7086627 0.515 rs12245180 chr10:82211897 C/G cg00277334 chr10:82204260 NA -0.85 -25.05 -0.7 5.02e-97 Post bronchodilator FEV1; BRCA cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg27572855 chr1:25598939 RHD -0.47 -13.55 -0.47 6.06e-37 Erythrocyte sedimentation rate; BRCA cis rs3008870 0.677 rs2815354 chr1:67483642 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.89 16.26 0.54 5.05e-50 Lymphocyte percentage of white cells; BRCA cis rs4948102 0.595 rs7793921 chr7:56120881 G/A cg09872392 chr7:56161020 PHKG1 -0.44 -11.11 -0.4 2.47e-26 Plasma homocysteine levels (post-methionine load test); BRCA cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg11168104 chr5:1857477 NA -0.32 -8.43 -0.32 2.35e-16 Cardiovascular disease risk factors; BRCA cis rs6748734 0.779 rs4401206 chr2:241796905 A/G cg07537917 chr2:241836409 C2orf54 -0.43 -10.42 -0.38 1.38e-23 Urinary metabolites; BRCA cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg13119609 chr19:45449297 APOC2 0.48 13.24 0.46 1.64e-35 Blood protein levels; BRCA cis rs2243480 1.000 rs313832 chr7:65550891 G/T cg18252515 chr7:66147081 NA -1.08 -15.16 -0.51 1.51e-44 Diabetic kidney disease; BRCA cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg05707623 chr12:122985044 ZCCHC8 0.41 8.5 0.32 1.36e-16 Body mass index; BRCA cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg16405210 chr4:1374714 KIAA1530 -0.36 -7.87 -0.3 1.58e-14 Obesity-related traits; BRCA cis rs7264396 0.635 rs6058346 chr20:34481043 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -13.45 -0.47 1.71e-36 Total cholesterol levels; BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg08470875 chr2:26401718 FAM59B -0.51 -8.17 -0.31 1.62e-15 Gut microbiome composition (summer); BRCA cis rs12612619 0.667 rs11126871 chr2:27344457 T/A cg00617064 chr2:27272375 NA 0.32 8.01 0.3 5.6e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7582720 1.000 rs72936304 chr2:204036357 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.25 0.44 3.99e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs9815354 0.812 rs111277902 chr3:41950312 C/T cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs113835537 0.529 rs3819247 chr11:66293779 T/C cg24851651 chr11:66362959 CCS 0.47 8.81 0.33 1.22e-17 Airway imaging phenotypes; BRCA cis rs7631605 0.905 rs4678940 chr3:37187513 G/A cg15934958 chr3:37212084 LRRFIP2 0.43 9.97 0.37 7.56e-22 Cerebrospinal P-tau181p levels; BRCA cis rs4965272 1.000 rs1480955 chr15:100581989 T/A cg27344315 chr15:100560801 ADAMTS17 0.39 8.1 0.31 2.78e-15 Gastroesophageal reflux disease; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.17 -0.43 8.62e-31 Alzheimer's disease; BRCA trans rs9329221 0.725 rs11250001 chr8:10255901 G/A cg06636001 chr8:8085503 FLJ10661 -0.49 -9.42 -0.35 7.92e-20 Neuroticism; BRCA cis rs6882046 0.513 rs587490 chr5:88032522 C/T cg22951263 chr5:87985283 NA -0.38 -10.66 -0.39 1.58e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs9818758 0.607 rs35673421 chr3:49139406 G/A cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1691799 0.899 rs1168292 chr12:66732660 C/T cg16791601 chr12:66731901 HELB -0.65 -17.6 -0.57 7.75e-57 White blood cell count (basophil); BRCA cis rs9467773 1.000 rs9461271 chr6:26554968 G/A cg09904177 chr6:26538194 HMGN4 0.55 17.68 0.57 3.11e-57 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.46e-23 Prostate cancer; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 14.77 0.5 1.09e-42 Platelet count; BRCA cis rs4595586 0.525 rs73096109 chr12:39355720 C/A cg26384229 chr12:38710491 ALG10B 0.54 11.47 0.41 7.77e-28 Morning vs. evening chronotype; BRCA cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg12373951 chr3:133503437 NA 0.46 10.82 0.39 3.66e-25 Iron status biomarkers; BRCA cis rs312273 0.748 rs10879450 chr12:41367808 T/C cg17827154 chr12:41323612 CNTN1 -0.39 -10.12 -0.37 2.01e-22 Bipolar disorder; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg23358479 chr7:1110784 C7orf50 -0.47 -7.95 -0.3 8.75e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg11764359 chr7:65958608 NA -0.78 -17.82 -0.58 5.88e-58 Aortic root size; BRCA cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.34 -0.31 4.55e-16 Total body bone mineral density; BRCA cis rs6435161 1.000 rs72926976 chr2:203512138 C/A cg18429434 chr2:203499731 FAM117B -0.45 -8.83 -0.33 9.7e-18 Total cholesterol levels; BRCA cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg24642439 chr20:33292090 TP53INP2 -0.64 -13.18 -0.46 2.8e-35 Coronary artery disease; BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg22800045 chr5:56110881 MAP3K1 0.55 10.24 0.38 6.72e-23 Initial pursuit acceleration; BRCA cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.36 -0.38 2.35e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9300255 0.543 rs655293 chr12:123528405 G/A cg00376283 chr12:123451042 ABCB9 0.51 11.53 0.41 4.56e-28 Neutrophil percentage of white cells; BRCA cis rs9768139 0.733 rs10156158 chr7:158122287 G/T cg24154853 chr7:158122151 PTPRN2 0.34 7.85 0.3 1.81e-14 Calcium levels; BRCA cis rs7246967 0.551 rs16998998 chr19:22911116 T/C cg23217946 chr19:22817039 ZNF492 0.5 9.16 0.34 6.71e-19 Bronchopulmonary dysplasia; BRCA cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs9814567 1.000 rs9814567 chr3:134218557 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 8.75 0.33 1.89e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg17211192 chr8:82754475 SNX16 -0.49 -11.16 -0.4 1.5e-26 Diastolic blood pressure; BRCA cis rs637571 0.544 rs617791 chr11:65702523 C/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.44 9.08 0.34 1.3e-18 Eosinophil percentage of white cells; BRCA cis rs1865721 0.656 rs727894 chr18:73137117 C/T cg26385618 chr18:73139727 C18orf62 -0.36 -9.03 -0.34 2.08e-18 Intelligence; BRCA cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg20891283 chr12:69753455 YEATS4 0.84 28.41 0.75 1.93e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.88 -0.4 2.03e-25 Personality dimensions; BRCA cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg08508325 chr11:3079039 CARS -0.43 -15.37 -0.52 1.38e-45 Longevity; BRCA cis rs13046373 0.535 rs2832970 chr21:32020767 T/C cg22337977 chr21:31811175 KRTAP15-1 0.33 7.86 0.3 1.6e-14 HDL cholesterol; BRCA cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg24011408 chr12:48396354 COL2A1 0.54 9.14 0.34 8.5e-19 Lung cancer; BRCA trans rs9409565 1.000 rs9409565 chr9:97251034 C/T cg05679027 chr9:99775184 HIATL2 -0.36 -7.85 -0.3 1.75e-14 Colorectal cancer (alcohol consumption interaction); BRCA cis rs7737355 0.947 rs10478980 chr5:130618247 C/T cg06307176 chr5:131281290 NA 0.46 8.91 0.33 5.14e-18 Life satisfaction; BRCA cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg00101154 chr16:420108 MRPL28 0.46 10.64 0.39 1.87e-24 Bone mineral density (spine);Bone mineral density; BRCA cis rs6446731 0.614 rs6446727 chr4:3274488 T/A cg08886695 chr4:3369023 RGS12 -0.38 -10.01 -0.37 5.02e-22 Mean platelet volume; BRCA cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs34526934 0.566 rs34028621 chr2:177042779 C/T cg26754761 chr2:177040938 NA -0.45 -8.78 -0.33 1.43e-17 Obstructive sleep apnea trait (apnea hypopnea index); BRCA cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg21479132 chr6:26055353 NA 0.56 8.03 0.3 4.84e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg20848291 chr7:100343083 ZAN 0.36 8.13 0.31 2.17e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs6598955 0.671 rs8564 chr1:26605069 T/C cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs829883 1.000 rs829883 chr12:98879606 G/A cg25150519 chr12:98850993 NA 0.58 11.77 0.42 4.21e-29 Colorectal adenoma (advanced); BRCA cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs3862030 0.839 rs7078511 chr10:104283874 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.03 -0.43 3.53e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg00717180 chr2:96193071 NA -0.37 -10.23 -0.38 7.69e-23 Height; BRCA cis rs13102973 0.899 rs4479760 chr4:135867474 T/C cg14419869 chr4:135874104 NA 0.51 10.89 0.4 1.89e-25 Subjective well-being; BRCA cis rs1355223 0.507 rs11032903 chr11:34876176 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg15605315 chr1:45957053 TESK2 0.49 9.83 0.36 2.41e-21 High light scatter reticulocyte count; BRCA cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.44 12.32 0.44 1.93e-31 Monocyte percentage of white cells; BRCA cis rs6893300 0.524 rs12522926 chr5:179214818 G/A cg14593053 chr5:179126677 CANX 0.48 13.17 0.46 3.21e-35 Resting heart rate; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg00814883 chr7:100076585 TSC22D4 0.5 10.27 0.38 5.29e-23 Platelet count; BRCA cis rs1420338 0.933 rs12540602 chr7:34174056 G/A cg01275685 chr7:34179230 BMPER -0.51 -11.27 -0.41 5.39e-27 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs875971 0.545 rs221986 chr7:65570310 T/C cg11764359 chr7:65958608 NA -0.64 -11.36 -0.41 2.28e-27 Aortic root size; BRCA cis rs4919694 0.572 rs4917995 chr10:104845443 A/T cg04362960 chr10:104952993 NT5C2 -0.72 -12.66 -0.45 6.06e-33 Arsenic metabolism; BRCA cis rs7945718 0.935 rs4757059 chr11:12812356 G/A cg25843174 chr11:12811716 TEAD1 -0.23 -8.67 -0.32 3.64e-17 Educational attainment (years of education); BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg05863683 chr7:1912471 MAD1L1 -0.35 -8.21 -0.31 1.21e-15 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg22535103 chr8:58192502 C8orf71 -0.44 -8.85 -0.33 8.47e-18 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.46 0.38 9.36e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs34779708 0.931 rs2384283 chr10:35326789 G/A cg03585969 chr10:35415529 CREM 0.56 11.56 0.42 3.36e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs60843830 1.000 rs9213 chr2:218386 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.56 0.59 7.92e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg03213289 chr20:61660250 NA 0.61 16.23 0.54 7.73e-50 Prostate cancer (SNP x SNP interaction); BRCA trans rs7618501 0.573 rs7634917 chr3:50049299 T/G cg21659725 chr3:3221576 CRBN -0.5 -12.78 -0.45 1.75e-33 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg11663144 chr21:46675770 NA -0.62 -14.15 -0.49 9.92e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1200821 0.529 rs4934856 chr10:37807847 T/C cg25427524 chr10:38739819 LOC399744 0.43 8.97 0.33 3.29e-18 Hemostatic factors and hematological phenotypes; BRCA cis rs12474201 0.894 rs34401107 chr2:46972768 A/C cg06386533 chr2:46925753 SOCS5 0.83 18.7 0.59 1.4e-62 Height; BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg21143896 chr7:2802374 GNA12 -0.34 -8.39 -0.32 3.09e-16 Height; BRCA cis rs11229555 0.609 rs12289198 chr11:58175057 T/C cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg03433033 chr1:76189801 ACADM 0.62 13.83 0.48 3.11e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs7772486 0.875 rs2814871 chr6:146312274 G/T cg23711669 chr6:146136114 FBXO30 0.64 14.61 0.5 6.74e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs11229555 1.000 rs11229555 chr11:58408687 G/T cg15696309 chr11:58395628 NA -0.52 -11.61 -0.42 2.13e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs3770081 1.000 rs2303339 chr2:86346180 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 0.67 8.86 0.33 8.1e-18 Facial emotion recognition (sad faces); BRCA cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg06552810 chr11:31128660 NA -0.4 -8.82 -0.33 1.09e-17 Red blood cell count; BRCA cis rs11098499 0.913 rs68128210 chr4:120137819 T/G cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.72e-26 Corneal astigmatism; BRCA trans rs8002861 0.901 rs9525867 chr13:44463557 G/A cg17145862 chr1:211918768 LPGAT1 0.74 19.7 0.61 7.66e-68 Leprosy; BRCA trans rs225245 0.782 rs225293 chr17:33925906 A/G cg19694781 chr19:47549865 TMEM160 -0.32 -7.85 -0.3 1.8e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.85 -0.3 1.74e-14 Total body bone mineral density; BRCA cis rs7647973 0.626 rs62260720 chr3:49853796 T/A cg07636037 chr3:49044803 WDR6 -0.49 -8.13 -0.31 2.23e-15 Menarche (age at onset); BRCA trans rs2235573 0.527 rs139883 chr22:38369027 C/T cg19894588 chr14:64061835 NA 0.34 8.43 0.32 2.32e-16 Glioblastoma;Glioma; BRCA cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs2204008 0.806 rs11525001 chr12:38234397 A/G cg26384229 chr12:38710491 ALG10B 0.66 15.05 0.51 4.81e-44 Bladder cancer; BRCA cis rs757081 0.667 rs12577418 chr11:17101554 C/G cg15432903 chr11:17409602 KCNJ11 -0.47 -8.59 -0.32 6.48e-17 Systolic blood pressure; BRCA cis rs6545883 0.929 rs2694625 chr2:61616055 G/A cg15711740 chr2:61764176 XPO1 0.52 12.75 0.45 2.4e-33 Tuberculosis; BRCA cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg26384229 chr12:38710491 ALG10B -0.53 -13.35 -0.47 4.93e-36 Morning vs. evening chronotype; BRCA cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg27129171 chr3:47204927 SETD2 0.7 16.95 0.56 1.76e-53 Colorectal cancer; BRCA cis rs2832191 0.632 rs2246777 chr21:30309586 T/C cg08807101 chr21:30365312 RNF160 -0.73 -19.02 -0.6 3e-64 Dental caries; BRCA cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg04586622 chr2:25135609 ADCY3 0.46 11.53 0.42 4.28e-28 Body mass index; BRCA cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg24060327 chr5:131705240 SLC22A5 -0.63 -12.05 -0.43 2.95e-30 Breast cancer; BRCA cis rs4787491 0.729 rs4788215 chr16:30047930 G/A cg06326092 chr16:30034487 C16orf92 0.38 9.9 0.36 1.38e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs4596713 0.568 rs6560585 chr9:71747395 A/G cg16512924 chr15:28394682 HERC2 0.39 9.47 0.35 5.51e-20 Headache; BRCA trans rs6076960 0.598 rs3905168 chr20:6226752 C/T cg21095983 chr6:86352623 SYNCRIP 0.42 9.2 0.34 4.84e-19 Smooth-surface caries; BRCA cis rs672059 1.000 rs551569 chr1:183158293 G/C ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.26e-17 Hypertriglyceridemia; BRCA cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.24e-26 Bipolar disorder; BRCA cis rs4076764 1.000 rs7528020 chr1:163426537 G/A cg06092702 chr1:163392909 NA -0.33 -8.68 -0.32 3.17e-17 Motion sickness; BRCA cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg02544614 chr20:61657117 NA 0.29 8.19 0.31 1.45e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg25237894 chr2:233734115 C2orf82 0.4 11.48 0.41 7.43e-28 Coronary artery disease; BRCA cis rs514406 0.505 rs856721 chr1:53162156 C/A cg24675658 chr1:53192096 ZYG11B -0.65 -14.34 -0.49 1.24e-40 Monocyte count; BRCA cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg01528321 chr10:82214614 TSPAN14 0.64 14.64 0.5 4.66e-42 Post bronchodilator FEV1; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg23708337 chr7:1209742 NA 0.49 8.4 0.32 2.81e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7246967 0.551 rs8103204 chr19:22936517 T/A cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs3768617 0.510 rs1886500 chr1:183095048 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg22920501 chr2:26401640 FAM59B 0.9 16.59 0.55 1.12e-51 Gut microbiome composition (summer); BRCA cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg16405210 chr4:1374714 KIAA1530 0.69 14.29 0.49 2.13e-40 Obesity-related traits; BRCA cis rs34375054 0.526 rs4412800 chr12:125674742 C/T cg25124228 chr12:125621409 AACS 0.45 9.44 0.35 6.77e-20 Post bronchodilator FEV1/FVC ratio; BRCA cis rs9462846 0.959 rs9471954 chr6:42880326 C/A cg05552183 chr6:42928497 GNMT 0.45 7.93 0.3 1.01e-14 Blood protein levels; BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.14 0.58 1.22e-59 Platelet count; BRCA cis rs9337951 0.596 rs3739998 chr10:30316072 C/G cg00730780 chr10:30316187 KIAA1462 0.48 10.09 0.37 2.7e-22 Pulse pressure;Coronary artery disease; BRCA trans rs1005277 0.502 rs2800484 chr10:38542415 C/T cg17830980 chr10:43048298 ZNF37B -0.52 -12.59 -0.45 1.26e-32 Extrinsic epigenetic age acceleration; BRCA cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg20573242 chr4:122745356 CCNA2 0.49 10.93 0.4 1.25e-25 Type 2 diabetes; BRCA cis rs17092148 0.887 rs6059915 chr20:33147737 C/G cg16810054 chr20:33298113 TP53INP2 -0.46 -10.35 -0.38 2.59e-23 Neuroticism; BRCA cis rs9527 0.640 rs7089061 chr10:104723015 C/A cg04362960 chr10:104952993 NT5C2 0.45 10.42 0.38 1.39e-23 Arsenic metabolism; BRCA cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.38e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg02297831 chr4:17616191 MED28 0.36 8.47 0.32 1.67e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg23711669 chr6:146136114 FBXO30 0.72 16.75 0.55 1.67e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg14008862 chr17:28927542 LRRC37B2 0.58 8.08 0.3 3.28e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs796364 1.000 rs281774 chr2:200814572 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 11.94 0.43 8.59e-30 Schizophrenia; BRCA cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg12365402 chr11:9010492 NRIP3 -0.36 -7.86 -0.3 1.58e-14 Hematocrit; BRCA cis rs528301 0.868 rs570305 chr2:45142726 C/G cg02372786 chr2:45167549 SIX3 -0.49 -11.37 -0.41 2.1e-27 Alcohol and nicotine co-dependence; BRCA cis rs921968 0.541 rs933995 chr2:219650718 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -11.05 -0.4 4.09e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs514406 0.621 rs928452 chr1:53195926 G/C cg16325326 chr1:53192061 ZYG11B -0.95 -26.1 -0.72 8.67e-103 Monocyte count; BRCA cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.6 8.29 0.31 6.94e-16 Putamen volume; BRCA cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg04248312 chr19:17393744 ANKLE1 -0.87 -19.22 -0.61 2.5e-65 Systemic lupus erythematosus; BRCA cis rs708547 0.581 rs13121027 chr4:57813369 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.35 -8.65 -0.32 4.28e-17 Response to bleomycin (chromatid breaks); BRCA cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg22105103 chr4:187893119 NA 0.41 13.27 0.46 1.16e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs3820928 0.874 rs4144328 chr2:227790187 A/C cg11843606 chr2:227700838 RHBDD1 -0.39 -8.74 -0.33 1.99e-17 Pulmonary function; BRCA trans rs208520 0.874 rs208518 chr6:66948501 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.89 16.37 0.54 1.39e-50 Exhaled nitric oxide output; BRCA cis rs4242434 0.927 rs3736147 chr8:22471824 A/G cg03733263 chr8:22462867 KIAA1967 -0.95 -21.25 -0.64 3.18e-76 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg04455712 chr21:45112962 RRP1B -0.4 -10.07 -0.37 3.04e-22 Mean corpuscular volume; BRCA cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg06108461 chr20:60628389 TAF4 -0.97 -21.29 -0.64 2.06e-76 Body mass index; BRCA cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg11645453 chr3:52864694 ITIH4 0.49 11.85 0.42 1.94e-29 Schizophrenia; BRCA cis rs12530845 0.887 rs4492299 chr7:135315690 T/G cg23117316 chr7:135346802 PL-5283 -0.35 -8.17 -0.31 1.62e-15 Red blood cell traits; BRCA cis rs2346177 0.542 rs13020043 chr2:46698431 A/T cg02822958 chr2:46747628 ATP6V1E2 0.57 11.12 0.4 2.31e-26 HDL cholesterol; BRCA cis rs2625529 0.712 rs2054601 chr15:72184968 T/C cg16672083 chr15:72433130 SENP8 -0.82 -17.19 -0.56 1.07e-54 Red blood cell count; BRCA cis rs7267979 1.000 rs2500424 chr20:25391969 C/T cg08601574 chr20:25228251 PYGB -0.39 -9.04 -0.34 1.84e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.38e-19 Total body bone mineral density; BRCA cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg17845761 chr1:175162550 KIAA0040 0.25 9.7 0.36 7.43e-21 Alcohol dependence; BRCA cis rs10751667 0.600 rs11246380 chr11:1009890 T/C ch.11.42038R chr11:967971 AP2A2 0.45 13.45 0.47 1.77e-36 Alzheimer's disease (late onset); BRCA cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg10523679 chr1:76189770 ACADM -0.73 -14.64 -0.5 4.56e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7520050 0.966 rs9429183 chr1:46524582 G/A cg24296786 chr1:45957014 TESK2 0.41 9.12 0.34 9.33e-19 Red blood cell count;Reticulocyte count; BRCA cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA trans rs8073060 0.592 rs225306 chr17:33920036 A/C cg19694781 chr19:47549865 TMEM160 0.56 12.9 0.45 5.11e-34 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs10227331 0.632 rs10215531 chr7:157301180 A/G cg04156418 chr7:157293606 NA 0.33 9.21 0.34 4.74e-19 Inattentive symptoms; BRCA cis rs7715806 0.500 rs34355 chr5:74959970 G/A cg19683494 chr5:74908142 NA -0.57 -8.72 -0.33 2.45e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg01028140 chr2:1542097 TPO -0.58 -12.18 -0.43 8e-31 IgG glycosylation; BRCA trans rs6952808 0.573 rs12668848 chr7:2020995 G/A cg04565464 chr8:145669602 NFKBIL2 0.4 9.85 0.36 2.1e-21 Bipolar disorder and schizophrenia; BRCA cis rs6080550 1.000 rs73606110 chr20:1759957 G/A cg03128590 chr20:1760507 NA -0.54 -9.09 -0.34 1.22e-18 Non-obstructive azoospermia; BRCA cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg05623727 chr3:50126028 RBM5 0.42 9.73 0.36 5.68e-21 Intelligence (multi-trait analysis); BRCA trans rs2018683 0.600 rs6948880 chr7:29003478 C/T cg19402173 chr7:128379420 CALU -0.48 -11.61 -0.42 2.05e-28 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg08859206 chr1:53392774 SCP2 0.67 13.78 0.48 5.27e-38 Monocyte count; BRCA cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.64 -0.36 1.27e-20 Alcohol dependence; BRCA cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg01689657 chr7:91764605 CYP51A1 0.23 8.37 0.31 3.68e-16 Breast cancer; BRCA trans rs4689592 0.554 rs66925245 chr4:7071999 C/T cg07817883 chr1:32538562 TMEM39B 0.49 8.1 0.31 2.72e-15 Monocyte percentage of white cells; BRCA cis rs4853036 0.857 rs12613717 chr2:70039263 T/G cg02498382 chr2:70120550 SNRNP27 -0.49 -8.86 -0.33 7.63e-18 Colorectal or endometrial cancer; BRCA cis rs7647973 0.961 rs6778080 chr3:49317338 C/T cg07636037 chr3:49044803 WDR6 -0.59 -12.38 -0.44 1e-31 Menarche (age at onset); BRCA cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg06627628 chr2:24431161 ITSN2 -0.82 -14.8 -0.51 8.19e-43 Asthma; BRCA cis rs9880211 0.948 rs34913797 chr3:136127570 G/A cg21827317 chr3:136751795 NA -0.47 -8.32 -0.31 5.34e-16 Body mass index;Height; BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00166722 chr3:10149974 C3orf24 0.64 12.62 0.45 9.76e-33 Alzheimer's disease; BRCA cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg23173402 chr1:227635558 NA 0.53 9.62 0.36 1.46e-20 Major depressive disorder; BRCA trans rs4957048 0.891 rs11960196 chr5:568857 C/A cg25482853 chr8:67687455 SGK3 0.78 13.92 0.48 1.13e-38 Ulcerative colitis; BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg04025307 chr7:1156635 C7orf50 0.47 9.32 0.35 1.86e-19 Bronchopulmonary dysplasia; BRCA cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg13393036 chr8:95962371 TP53INP1 -0.34 -9.13 -0.34 8.57e-19 Type 2 diabetes; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.52 -0.52 2.52e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs990171 0.506 rs9284725 chr2:102744854 C/A cg22835712 chr2:102737379 NA 0.6 11.32 0.41 3.42e-27 Lymphocyte counts; BRCA cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg06552810 chr11:31128660 NA -0.39 -8.81 -0.33 1.21e-17 Red blood cell count; BRCA cis rs4389656 0.857 rs274699 chr5:6730332 A/C cg10857441 chr5:6722123 POLS -0.25 -7.82 -0.3 2.21e-14 Coronary artery disease; BRCA cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg18713687 chr3:195489789 MUC4 -0.56 -8.91 -0.33 5.22e-18 Lung disease severity in cystic fibrosis; BRCA cis rs1401999 0.628 rs7639048 chr3:183746044 A/G cg20387954 chr3:183756860 HTR3D 0.41 9.22 0.34 4.23e-19 Anterior chamber depth; BRCA cis rs10992471 0.729 rs6479418 chr9:95064762 G/A cg14631576 chr9:95140430 CENPP -0.36 -8.65 -0.32 4.12e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA trans rs2204008 0.805 rs11179579 chr12:38213957 A/C cg06521331 chr12:34319734 NA -0.5 -9.31 -0.35 1.97e-19 Bladder cancer; BRCA cis rs6433857 0.657 rs6756509 chr2:181500273 T/C cg23363182 chr2:181467187 NA -0.45 -9.73 -0.36 5.81e-21 Body mass index; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.24 -0.31 9.83e-16 Total body bone mineral density; BRCA cis rs2760061 0.598 rs590657 chr1:228117581 A/C cg02753203 chr1:228287806 NA -0.58 -12.16 -0.43 9.57e-31 Diastolic blood pressure; BRCA trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 3.77e-39 Extrinsic epigenetic age acceleration; BRCA cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.92 -0.46 4.11e-34 Chronic sinus infection; BRCA cis rs3008870 0.755 rs11208974 chr1:67398119 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.09 0.49 1.81e-39 Lymphocyte percentage of white cells; BRCA cis rs10883723 0.775 rs2296579 chr10:104241375 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.25 0.61 1.87e-65 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg08888203 chr3:10149979 C3orf24 0.63 11.48 0.41 7.36e-28 Alzheimer's disease; BRCA cis rs11190604 1.000 rs4919466 chr10:102241213 T/C cg07080220 chr10:102295463 HIF1AN 0.5 11.53 0.41 4.65e-28 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg23583168 chr7:148888333 NA -0.79 -18.42 -0.59 4.27e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg10729496 chr3:10149963 C3orf24 0.44 8.13 0.31 2.21e-15 Alzheimer's disease; BRCA cis rs733592 0.507 rs10747529 chr12:48473369 G/A cg24011408 chr12:48396354 COL2A1 -0.44 -9.85 -0.36 2.05e-21 Plateletcrit; BRCA cis rs7662987 0.517 rs2602883 chr4:100040914 A/T cg13256891 chr4:100009986 ADH5 0.52 9.56 0.35 2.54e-20 Smoking initiation; BRCA cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.4 0.41 1.52e-27 Homoarginine levels; BRCA cis rs1595825 0.945 rs7426250 chr2:198837358 G/A cg19156104 chr2:198669113 PLCL1 -0.44 -8.18 -0.31 1.48e-15 Ulcerative colitis; BRCA cis rs2204008 0.744 rs11514071 chr12:38392076 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.32 0.38 3.52e-23 Bladder cancer; BRCA cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg20908204 chr19:46285434 DMPK -0.29 -8.55 -0.32 8.79e-17 Coronary artery disease; BRCA cis rs1511802 0.625 rs7667777 chr4:187126077 C/G cg24794857 chr4:187113578 CYP4V2 0.37 7.81 0.3 2.39e-14 Blood protein levels; BRCA cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg17420585 chr12:42539391 GXYLT1 -0.38 -8.08 -0.3 3.27e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg05527609 chr1:210001259 C1orf107 -0.77 -15.96 -0.53 1.72e-48 Orofacial clefts; BRCA cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg04450456 chr4:17643702 FAM184B 0.33 9.43 0.35 7.14e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1499972 0.817 rs62263118 chr3:117629053 C/T cg07612923 chr3:117604196 NA 0.6 8.15 0.31 1.97e-15 Schizophrenia; BRCA cis rs7127900 0.583 rs11043142 chr11:2234042 A/G cg12428727 chr11:2234665 NA 0.54 13.21 0.46 2.08e-35 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); BRCA trans rs12439619 0.846 rs62012004 chr15:82476265 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.4 -7.92 -0.3 1.02e-14 Intelligence (multi-trait analysis); BRCA cis rs6545883 0.894 rs7602859 chr2:61458206 A/T cg15711740 chr2:61764176 XPO1 0.48 11.91 0.43 1.13e-29 Tuberculosis; BRCA cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.66 -0.39 1.62e-24 Personality dimensions; BRCA cis rs6121246 0.909 rs6060793 chr20:30288830 T/G cg21427119 chr20:30132790 HM13 -0.42 -8.74 -0.33 1.98e-17 Mean corpuscular hemoglobin; BRCA cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg11064039 chr7:766100 PRKAR1B;HEATR2 0.72 9.91 0.37 1.19e-21 Initial pursuit acceleration; BRCA cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.64 0.32 4.5e-17 Glomerular filtration rate (creatinine); BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -8.93 -0.33 4.47e-18 Longevity;Endometriosis; BRCA cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.26 0.38 5.81e-23 Bipolar disorder; BRCA cis rs7607369 0.637 rs17462630 chr2:219286541 C/G cg02176678 chr2:219576539 TTLL4 -0.51 -12.15 -0.43 1.03e-30 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -14.93 -0.51 1.84e-43 Cognitive function; BRCA cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg05472934 chr7:22766657 IL6 0.49 12.55 0.44 1.88e-32 Lung cancer; BRCA cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.97 0.6 5.18e-64 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.09 -0.4 2.84e-26 Lymphocyte counts; BRCA cis rs1401999 0.628 rs6798870 chr3:183740350 G/A cg01324343 chr3:183735012 ABCC5 0.7 16.55 0.55 1.92e-51 Anterior chamber depth; BRCA cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg04267008 chr7:1944627 MAD1L1 -0.43 -8.5 -0.32 1.32e-16 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6684514 1.000 rs12130361 chr1:156260301 C/T cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs10189230 0.967 rs1864460 chr2:222347655 A/C cg14652038 chr2:222343519 EPHA4 0.48 13.27 0.46 1.11e-35 Urate levels in lean individuals; BRCA cis rs6450176 0.953 rs3776724 chr5:53292270 A/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.11 -0.49 1.51e-39 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg14664628 chr15:75095509 CSK -0.59 -14.42 -0.5 4.92e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs9790314 0.586 rs11713185 chr3:161111357 C/G cg03342759 chr3:160939853 NMD3 -0.62 -14.03 -0.49 3.69e-39 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.61 -11.2 -0.41 1e-26 Alzheimer's disease; BRCA cis rs9463078 0.764 rs2396370 chr6:44946472 A/G cg25276700 chr6:44698697 NA -0.36 -8.32 -0.31 5.2e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg20573242 chr4:122745356 CCNA2 0.44 9.94 0.37 9.4e-22 Type 2 diabetes; BRCA cis rs10197940 0.662 rs72860233 chr2:152289767 G/A cg06191203 chr2:152266755 RIF1 -0.42 -12.21 -0.43 6.03e-31 Lung cancer; BRCA cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.67 0.32 3.69e-17 Personality dimensions; BRCA trans rs35110281 0.714 rs2282526 chr21:45080552 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.28 0.38 4.78e-23 Mean corpuscular volume; BRCA cis rs943466 0.513 rs943467 chr6:33731811 A/T cg25922239 chr6:33757077 LEMD2 0.33 8.19 0.31 1.39e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg26384229 chr12:38710491 ALG10B 0.73 17.0 0.56 9.24e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs672059 1.000 rs563026 chr1:183161037 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.38 -8.72 -0.33 2.32e-17 Hypertriglyceridemia; BRCA cis rs9403521 1.000 rs6901659 chr6:143985106 T/C cg18240653 chr6:144019428 PHACTR2 -0.4 -7.9 -0.3 1.21e-14 Obesity-related traits; BRCA cis rs312273 0.846 rs312264 chr12:41251889 T/C cg17827154 chr12:41323612 CNTN1 -0.37 -8.85 -0.33 8.29e-18 Bipolar disorder; BRCA cis rs1448094 0.512 rs1900701 chr12:86236231 T/C cg19622623 chr12:86230825 RASSF9 -0.34 -9.52 -0.35 3.39e-20 Major depressive disorder; BRCA cis rs701145 1.000 rs355784 chr3:153986371 A/C cg17054900 chr3:154042577 DHX36 0.67 11.49 0.41 6.85e-28 Coronary artery disease; BRCA cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg04450456 chr4:17643702 FAM184B 0.38 11.48 0.41 7.03e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7385804 0.761 rs1617640 chr7:100317298 C/A cg20848291 chr7:100343083 ZAN 0.37 8.26 0.31 8.54e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7246657 0.882 rs6508719 chr19:37877419 A/G cg18154014 chr19:37997991 ZNF793 0.49 9.58 0.35 2.05e-20 Coronary artery calcification; BRCA cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs6547741 0.844 rs9678851 chr2:27887034 C/A cg27432699 chr2:27873401 GPN1 -0.52 -10.97 -0.4 9.23e-26 Oral cavity cancer; BRCA cis rs17270561 0.609 rs9348692 chr6:25720812 A/G cg17691542 chr6:26056736 HIST1H1C 0.48 9.18 0.34 6.14e-19 Iron status biomarkers; BRCA cis rs250677 0.522 rs2217638 chr5:148364355 A/G cg18129178 chr5:148520854 ABLIM3 0.56 10.77 0.39 5.93e-25 Breast cancer; BRCA cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.47 9.2 0.34 5.02e-19 Lung cancer in ever smokers; BRCA cis rs4953076 0.573 rs2054005 chr2:44401843 C/T cg04920474 chr2:44395004 PPM1B 0.5 10.31 0.38 3.66e-23 Height; BRCA cis rs7726839 0.561 rs72703050 chr5:582917 A/C cg09021430 chr5:549028 NA -0.64 -15.32 -0.52 2.49e-45 Obesity-related traits; BRCA cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg12667521 chr19:29218732 NA 0.49 8.83 0.33 9.71e-18 Methadone dose in opioid dependence; BRCA cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg19784903 chr17:45786737 TBKBP1 -0.33 -7.83 -0.3 2.11e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11098499 0.863 rs7678400 chr4:120461957 G/A cg09307838 chr4:120376055 NA 0.7 14.09 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.28 -0.31 7.41e-16 Bipolar disorder; BRCA cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg16070123 chr10:51489643 NA 0.38 8.69 0.32 3.11e-17 Prostate-specific antigen levels; BRCA cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg11266682 chr4:10021025 SLC2A9 0.49 12.82 0.45 1.23e-33 Bone mineral density; BRCA cis rs1577917 0.958 rs11756615 chr6:86679835 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.08 -0.3 3.32e-15 Response to antipsychotic treatment; BRCA cis rs6684514 1.000 rs12122180 chr1:156244559 G/A cg16558208 chr1:156270281 VHLL 0.35 7.96 0.3 8.05e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7707921 0.881 rs73134709 chr5:81268499 G/A cg15871215 chr5:81402204 ATG10 -0.4 -8.22 -0.31 1.16e-15 Breast cancer; BRCA cis rs2243480 0.901 rs58207111 chr7:65486723 C/T cg18252515 chr7:66147081 NA -0.84 -12.26 -0.44 3.6e-31 Diabetic kidney disease; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg08999081 chr20:33150536 PIGU 0.47 12.92 0.46 4.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.46 9.62 0.36 1.52e-20 Tonsillectomy; BRCA cis rs754466 0.874 rs10430531 chr10:79660125 T/C cg17075019 chr10:79541650 NA -0.69 -13.06 -0.46 9.9e-35 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs17685 0.712 rs6954569 chr7:75738885 T/A cg19862616 chr7:65841803 NCRNA00174 0.85 27.84 0.74 2.67e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1707322 0.686 rs2230659 chr1:46078884 C/T cg03146154 chr1:46216737 IPP -0.51 -11.19 -0.4 1.11e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg25482853 chr8:67687455 SGK3 1.02 16.08 0.54 4.27e-49 Lung disease severity in cystic fibrosis; BRCA cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg02734326 chr4:10020555 SLC2A9 0.37 8.02 0.3 5.08e-15 Bone mineral density; BRCA cis rs921968 0.565 rs4674328 chr2:219593203 T/C cg02176678 chr2:219576539 TTLL4 -0.42 -11.18 -0.4 1.22e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg24642844 chr7:1081250 C7orf50 -0.88 -16.21 -0.54 9.48e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs67460515 0.852 rs2404341 chr3:161092405 T/C cg04691961 chr3:161091175 C3orf57 -0.39 -8.72 -0.33 2.46e-17 Parkinson's disease; BRCA cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg14819504 chr2:160761413 LY75 -0.38 -9.34 -0.35 1.52e-19 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg15556689 chr8:8085844 FLJ10661 0.41 10.2 0.37 9.85e-23 Neuroticism; BRCA cis rs6495367 0.803 rs2870111 chr15:79403585 C/T cg17916960 chr15:79447300 NA 0.39 9.24 0.34 3.51e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg18538332 chr22:24372958 LOC391322 -0.55 -13.57 -0.47 4.72e-37 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.93 0.33 4.51e-18 Motion sickness; BRCA cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.08 -0.54 4.01e-49 Alzheimer's disease (late onset); BRCA cis rs7512552 0.780 rs55823828 chr1:150467296 G/C cg15654264 chr1:150340011 RPRD2 0.39 8.35 0.31 4.36e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA trans rs6479891 1.000 rs72829170 chr10:64940289 A/G cg14819942 chr15:35414228 NA 0.35 8.52 0.32 1.13e-16 Arthritis (juvenile idiopathic); BRCA cis rs10129255 0.500 rs7161740 chr14:107184358 G/T cg07958169 chr14:107095056 NA -0.39 -8.3 -0.31 6.3e-16 Kawasaki disease; BRCA cis rs9467773 1.000 rs9393732 chr6:26530898 G/A cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.714 rs11520135 chr12:38114863 C/T cg06521331 chr12:34319734 NA -0.53 -9.53 -0.35 3.16e-20 Bladder cancer; BRCA cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg24675658 chr1:53192096 ZYG11B 0.67 14.68 0.5 3.02e-42 Monocyte count; BRCA cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg00277334 chr10:82204260 NA -0.85 -24.9 -0.7 3.41e-96 Post bronchodilator FEV1; BRCA cis rs2276314 1.000 rs2298715 chr18:33552425 T/C cg19628046 chr18:33552617 C18orf21 0.63 12.99 0.46 2.07e-34 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00166722 chr3:10149974 C3orf24 0.61 11.95 0.43 7.46e-30 Alzheimer's disease; BRCA cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg01528321 chr10:82214614 TSPAN14 0.63 14.24 0.49 3.47e-40 Post bronchodilator FEV1; BRCA cis rs1595825 0.891 rs73056811 chr2:198766642 T/C cg19156104 chr2:198669113 PLCL1 -0.41 -7.82 -0.3 2.17e-14 Ulcerative colitis; BRCA cis rs2836633 0.895 rs62217513 chr21:40024416 A/T cg05519781 chr21:40033154 ERG 0.46 9.78 0.36 3.72e-21 Coronary artery disease; BRCA cis rs208520 0.955 rs17644076 chr6:67004973 A/G cg07460842 chr6:66804631 NA -0.83 -13.54 -0.47 6.61e-37 Exhaled nitric oxide output; BRCA cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.42 8.67 0.32 3.59e-17 Schizophrenia; BRCA cis rs13223928 0.631 rs12531881 chr7:3156842 C/T cg19214707 chr7:3157722 NA -0.42 -9.42 -0.35 8.11e-20 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs698833 0.852 rs698774 chr2:44584314 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.57 11.6 0.42 2.18e-28 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9814567 1.000 rs9851441 chr3:134315091 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.2 -0.34 5.17e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.14e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg03433033 chr1:76189801 ACADM -0.47 -9.81 -0.36 2.98e-21 Daytime sleep phenotypes; BRCA cis rs870825 0.932 rs28702958 chr4:185575562 C/T cg04058563 chr4:185651563 MLF1IP 0.64 10.71 0.39 1e-24 Blood protein levels; BRCA cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg17971929 chr21:40555470 PSMG1 0.74 16.43 0.54 7.65e-51 Cognitive function; BRCA cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg01579765 chr21:45077557 HSF2BP 0.41 11.28 0.41 4.91e-27 Mean corpuscular volume; BRCA cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg12863693 chr15:85201151 NMB -0.34 -7.99 -0.3 6.16e-15 P wave terminal force; BRCA cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg08975724 chr8:8085496 FLJ10661 -0.4 -8.29 -0.31 6.86e-16 Neuroticism; BRCA cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.41 -8.76 -0.33 1.79e-17 Colonoscopy-negative controls vs population controls; BRCA trans rs11662586 0.517 rs7230837 chr18:77695384 A/T cg05926928 chr17:57297772 GDPD1 0.46 9.03 0.34 2.02e-18 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs2153535 0.580 rs7741456 chr6:8452424 G/A cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs7927771 0.524 rs2170815 chr11:47875910 T/C cg20307385 chr11:47447363 PSMC3 0.41 9.43 0.35 7.15e-20 Subjective well-being; BRCA cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg24642439 chr20:33292090 TP53INP2 0.54 11.77 0.42 4.49e-29 Glomerular filtration rate (creatinine); BRCA trans rs8073060 0.586 rs225307 chr17:33918311 A/G cg19694781 chr19:47549865 TMEM160 1.01 21.02 0.64 6.02e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg14062083 chr21:31802829 KRTAP13-4 0.33 9.22 0.34 4.33e-19 HDL cholesterol; BRCA cis rs17253792 0.545 rs12893061 chr14:56016097 A/T cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg11941060 chr3:133502564 NA 0.51 12.39 0.44 9.65e-32 Iron status biomarkers; BRCA cis rs634534 0.622 rs624273 chr11:65712413 A/G cg26695010 chr11:65641043 EFEMP2 -0.35 -7.99 -0.3 6.34e-15 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs2274273 0.967 rs2094102 chr14:55591098 T/C cg04306507 chr14:55594613 LGALS3 0.32 8.86 0.33 7.64e-18 Protein biomarker; BRCA cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg06671706 chr8:8559999 CLDN23 -0.42 -8.01 -0.3 5.31e-15 Obesity-related traits; BRCA cis rs6815814 0.950 rs45588337 chr4:38807328 A/G cg02016764 chr4:38805732 TLR1 -0.6 -9.56 -0.35 2.42e-20 Breast cancer; BRCA cis rs6684428 1.000 rs58538058 chr1:56370474 G/A cg11651538 chr1:56320950 NA -0.46 -7.81 -0.3 2.32e-14 Airflow obstruction; BRCA trans rs12517041 1.000 rs1366453 chr5:23283409 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs870825 0.616 rs28636679 chr4:185627481 C/T cg04058563 chr4:185651563 MLF1IP 0.77 16.89 0.56 3.35e-53 Blood protein levels; BRCA cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg02403541 chr12:121454288 C12orf43 0.7 15.05 0.51 4.82e-44 N-glycan levels; BRCA cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg13877915 chr19:58951672 ZNF132 0.45 10.66 0.39 1.54e-24 Uric acid clearance; BRCA cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg06784218 chr1:46089804 CCDC17 0.5 12.01 0.43 4.08e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6750047 0.585 rs4670808 chr2:38267794 A/G cg07380506 chr2:38303506 CYP1B1 0.45 9.76 0.36 4.56e-21 Cutaneous malignant melanoma;Melanoma; BRCA cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg01181863 chr3:195395398 SDHAP2 -0.46 -8.18 -0.31 1.52e-15 Pancreatic cancer; BRCA cis rs7633857 0.532 rs9858335 chr3:160760146 A/G cg03342759 chr3:160939853 NMD3 -0.56 -11.83 -0.42 2.53e-29 Educational attainment (years of education); BRCA cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg23711669 chr6:146136114 FBXO30 0.65 13.34 0.47 5.52e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs72928364 1.000 rs62275198 chr3:100687973 A/G cg10123952 chr3:100791384 NA 0.53 7.89 0.3 1.3e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.56 -0.39 3.72e-24 Gut microbiome composition (summer); BRCA cis rs926392 1.000 rs926391 chr20:37690485 A/G cg16355469 chr20:37678765 NA 0.32 7.84 0.3 1.85e-14 Dialysis-related mortality; BRCA cis rs4268898 0.931 rs60716082 chr2:24526265 T/A cg06627628 chr2:24431161 ITSN2 -0.51 -10.39 -0.38 1.87e-23 Asthma; BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.88 -0.3 1.46e-14 Total body bone mineral density; BRCA cis rs7647973 0.593 rs9870755 chr3:49809841 A/G cg07636037 chr3:49044803 WDR6 0.48 7.99 0.3 6.28e-15 Menarche (age at onset); BRCA cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg15017067 chr4:17643749 FAM184B 0.27 8.04 0.3 4.24e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg08045932 chr20:61659980 NA 0.49 11.35 0.41 2.57e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg02734326 chr4:10020555 SLC2A9 -0.35 -7.81 -0.3 2.38e-14 Bone mineral density; BRCA cis rs12545109 0.800 rs1348082 chr8:57415016 A/G cg09654669 chr8:57350985 NA -0.39 -8.4 -0.32 2.82e-16 Obesity-related traits; BRCA cis rs35110281 0.600 rs11089092 chr21:45120994 A/C cg01579765 chr21:45077557 HSF2BP -0.41 -11.13 -0.4 1.99e-26 Mean corpuscular volume; BRCA cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.7e-15 Developmental language disorder (linguistic errors); BRCA cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg11502198 chr6:26597334 ABT1 -0.48 -9.54 -0.35 3.04e-20 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs9653442 0.547 rs1062143 chr2:100659796 A/G cg22139774 chr2:100720529 AFF3 -0.29 -8.15 -0.31 1.97e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg25036284 chr2:26402008 FAM59B -0.59 -10.23 -0.38 7.44e-23 Gut microbiome composition (summer); BRCA cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg08859206 chr1:53392774 SCP2 0.48 10.51 0.38 6.29e-24 Monocyte count; BRCA cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg18876405 chr7:65276391 NA 0.63 15.8 0.53 1.05e-47 Aortic root size; BRCA cis rs7098414 0.511 rs7899513 chr10:82150559 G/A cg01528321 chr10:82214614 TSPAN14 0.67 14.46 0.5 3.38e-41 Post bronchodilator FEV1; BRCA cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg04553112 chr3:125709451 NA -0.57 -8.7 -0.33 2.72e-17 Blood pressure (smoking interaction); BRCA cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg15839431 chr19:19639596 YJEFN3 0.42 9.24 0.34 3.72e-19 Bipolar disorder; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.81 0.48 3.93e-38 Platelet count; BRCA trans rs9291683 0.595 rs10939665 chr4:10037628 T/C cg26043149 chr18:55253948 FECH 0.42 9.08 0.34 1.35e-18 Bone mineral density; BRCA cis rs2408955 0.561 rs9971924 chr12:48479832 C/G cg24011408 chr12:48396354 COL2A1 -0.39 -7.9 -0.3 1.24e-14 Glycated hemoglobin levels; BRCA cis rs698833 0.886 rs698802 chr2:44697624 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.96 0.37 7.96e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs875971 0.638 rs801205 chr7:66022144 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.07 -0.3 3.54e-15 Aortic root size; BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.84 0.42 2.32e-29 Tonsillectomy; BRCA cis rs1215050 0.765 rs687795 chr4:98754912 C/G cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg22535103 chr8:58192502 C8orf71 -0.42 -8.34 -0.31 4.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg03806693 chr22:41940476 POLR3H -1.15 -22.86 -0.67 5.77e-85 Vitiligo; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA trans rs11098499 0.954 rs34858317 chr4:120387110 A/C cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs4853036 1.000 rs1454499 chr2:70062939 T/C cg02498382 chr2:70120550 SNRNP27 -0.44 -8.87 -0.33 7.4e-18 Colorectal or endometrial cancer; BRCA cis rs250677 0.652 rs168751 chr5:148438264 C/T cg23229984 chr5:148520753 ABLIM3 0.35 8.38 0.31 3.26e-16 Breast cancer; BRCA cis rs4481887 1.000 rs4916124 chr1:248466495 T/C cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.79e-18 Common traits (Other); BRCA cis rs12142240 0.731 rs6658556 chr1:46844180 A/C cg14993813 chr1:46806288 NSUN4 -0.51 -9.73 -0.36 5.66e-21 Menopause (age at onset); BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg00814883 chr7:100076585 TSC22D4 -0.54 -11.38 -0.41 1.92e-27 Platelet count; BRCA cis rs7020830 0.898 rs308492 chr9:37298020 C/T cg14294708 chr9:37120828 ZCCHC7 1.09 33.67 0.8 1.09e-143 Schizophrenia; BRCA cis rs858239 0.601 rs10224327 chr7:23161820 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.82 0.39 3.69e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs311392 0.867 rs364484 chr8:55093492 G/T cg11783602 chr8:55087084 NA -0.31 -9.12 -0.34 9.47e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs739496 0.542 rs7312913 chr12:111793552 A/G cg10833066 chr12:111807467 FAM109A 0.35 8.1 0.31 2.77e-15 Platelet count; BRCA cis rs9308433 0.529 rs4655333 chr1:214493549 A/G cg06198575 chr1:214491504 SMYD2 0.53 11.84 0.42 2.32e-29 IgG glycosylation; BRCA trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg06636001 chr8:8085503 FLJ10661 -0.57 -12.61 -0.45 1e-32 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs7539409 0.651 rs6576953 chr1:84316946 A/G cg10977910 chr1:84465055 TTLL7 0.71 10.71 0.39 1.01e-24 Alzheimer's disease; BRCA cis rs754466 0.580 rs1058198 chr10:79566632 G/A cg17075019 chr10:79541650 NA -0.76 -18.91 -0.6 1.19e-63 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg26913058 chr16:419975 MRPL28 0.37 8.68 0.32 3.32e-17 Bone mineral density (spine);Bone mineral density; BRCA trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21659725 chr3:3221576 CRBN 0.5 11.93 0.43 9.4e-30 Resting heart rate; BRCA cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15664640 chr17:80829946 TBCD -0.67 -17.54 -0.57 1.53e-56 Breast cancer; BRCA cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg13010199 chr12:38710504 ALG10B 0.45 9.38 0.35 1.16e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs9837602 1.000 rs62285462 chr3:99769834 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.31e-26 Breast cancer; BRCA cis rs1348850 0.567 rs4144276 chr2:178523420 T/C cg22681709 chr2:178499509 PDE11A -0.41 -9.1 -0.34 1.17e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.13 0.49 1.22e-39 Platelet count; BRCA cis rs17270561 0.609 rs9393658 chr6:25730438 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs7246657 0.722 rs2927747 chr19:38159530 C/T cg18154014 chr19:37997991 ZNF793 -0.49 -9.2 -0.34 4.98e-19 Coronary artery calcification; BRCA cis rs919433 0.679 rs10497806 chr2:198508951 G/A cg00792783 chr2:198669748 PLCL1 0.41 9.06 0.34 1.52e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.98 -19.75 -0.62 4.07e-68 Gut microbiome composition (summer); BRCA cis rs10754283 0.967 rs7515375 chr1:90109854 T/C cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA trans rs2204008 0.837 rs11172728 chr12:38070042 C/A cg06521331 chr12:34319734 NA -0.54 -10.21 -0.37 8.63e-23 Bladder cancer; BRCA cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg04166393 chr7:2884313 GNA12 0.4 8.53 0.32 1.07e-16 Height; BRCA cis rs72799341 1.000 rs35675346 chr16:30936081 G/A cg02466173 chr16:30829666 NA -0.41 -8.0 -0.3 5.86e-15 Diastolic blood pressure; BRCA cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg27535305 chr1:53392650 SCP2 -0.39 -9.35 -0.35 1.5e-19 Monocyte count; BRCA cis rs7809950 0.678 rs12670688 chr7:106821016 A/G cg23024343 chr7:107201750 COG5 0.45 8.82 0.33 1.06e-17 Coronary artery disease; BRCA cis rs6121246 0.821 rs115585940 chr20:30317902 T/C cg13852791 chr20:30311386 BCL2L1 0.74 12.21 0.43 5.76e-31 Mean corpuscular hemoglobin; BRCA cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg08975724 chr8:8085496 FLJ10661 0.44 8.84 0.33 9.01e-18 Mood instability; BRCA cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg07148914 chr20:33460835 GGT7 -0.36 -8.24 -0.31 9.7e-16 Height; BRCA cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs6752107 1.000 rs3828309 chr2:234180410 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.51 -11.06 -0.4 3.71e-26 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg12310025 chr6:25882481 NA -0.54 -13.07 -0.46 9.5e-35 Blood metabolite levels; BRCA cis rs765787 0.530 rs28897155 chr15:45533974 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.78e-15 Uric acid levels; BRCA cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg21770322 chr7:97807741 LMTK2 0.45 11.72 0.42 7.41e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg08917208 chr2:24149416 ATAD2B 0.91 13.42 0.47 2.48e-36 Lymphocyte counts; BRCA cis rs9790314 0.812 rs7631479 chr3:161139566 C/T cg04691961 chr3:161091175 C3orf57 -0.48 -11.6 -0.42 2.23e-28 Morning vs. evening chronotype; BRCA cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg00409905 chr10:38381863 ZNF37A -0.5 -10.51 -0.38 6.31e-24 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2191566 0.576 rs393536 chr19:44493018 T/C cg20607764 chr19:44506953 ZNF230 0.4 8.63 0.32 4.71e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs6772849 0.830 rs4857917 chr3:128376178 C/T cg16766828 chr3:128327626 NA -0.4 -8.85 -0.33 8.76e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs10911232 0.507 rs10911234 chr1:183053001 A/C ch.1.3577855R chr1:183094577 LAMC1 0.65 17.08 0.56 3.87e-54 Hypertriglyceridemia; BRCA cis rs4919087 0.892 rs10882881 chr10:99010067 T/A cg25902810 chr10:99078978 FRAT1 0.37 8.08 0.3 3.21e-15 Monocyte count; BRCA cis rs9381107 0.860 rs9369385 chr6:9477277 A/G cg14735645 chr6:9486422 NA -0.46 -8.11 -0.31 2.53e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg27541892 chr1:1571801 CDK11B -0.58 -12.99 -0.46 2.2e-34 Body mass index; BRCA cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.54e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg04756594 chr16:24857601 SLC5A11 0.52 11.8 0.42 3.19e-29 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg00990874 chr7:1149470 C7orf50 -0.59 -11.99 -0.43 4.88e-30 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs68170813 0.559 rs76933738 chr7:106814574 T/C cg02696742 chr7:106810147 HBP1 -0.55 -9.03 -0.34 2.07e-18 Coronary artery disease; BRCA cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7572733 0.576 rs1865586 chr2:198758868 C/T cg00792783 chr2:198669748 PLCL1 -0.45 -9.9 -0.36 1.35e-21 Dermatomyositis; BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg08885076 chr2:99613938 TSGA10 -0.53 -12.25 -0.44 3.9e-31 Chronic sinus infection; BRCA cis rs9427116 0.532 rs9426828 chr1:154591489 G/A cg17218026 chr1:154582156 ADAR 0.27 8.23 0.31 1.07e-15 Blood protein levels; BRCA cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg06238570 chr21:40685208 BRWD1 0.41 8.32 0.31 5.3e-16 Cognitive function; BRCA cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.66 -0.57 3.68e-57 Chronic sinus infection; BRCA cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg25067162 chr17:41277974 BRCA1;NBR2 -0.37 -8.22 -0.31 1.16e-15 Menopause (age at onset); BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.62 -0.32 5.25e-17 Total body bone mineral density; BRCA cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg06115741 chr20:33292138 TP53INP2 0.38 8.37 0.31 3.61e-16 Coronary artery disease; BRCA cis rs10193935 1.000 rs13411405 chr2:42413811 C/A cg27598129 chr2:42591480 NA -0.95 -15.02 -0.51 6.54e-44 Colonoscopy-negative controls vs population controls; BRCA trans rs853679 0.607 rs13211507 chr6:28257377 T/C cg01620082 chr3:125678407 NA -0.83 -9.94 -0.37 9.21e-22 Depression; BRCA cis rs4363385 0.818 rs3795382 chr1:153004853 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.21 -0.34 4.44e-19 Inflammatory skin disease; BRCA cis rs12618769 0.625 rs3820945 chr2:99105156 G/A cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -10.96 -0.4 9.67e-26 Extrinsic epigenetic age acceleration; BRCA cis rs7917772 0.582 rs729024 chr10:104341975 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg23708337 chr7:1209742 NA 0.53 11.08 0.4 3.34e-26 Longevity;Endometriosis; BRCA trans rs3780486 0.846 rs7036812 chr9:33143822 T/C cg04842962 chr6:43655489 MRPS18A 1.12 37.36 0.83 7.55e-163 IgG glycosylation; BRCA cis rs870825 0.616 rs7674952 chr4:185622327 A/C cg04058563 chr4:185651563 MLF1IP 0.78 17.35 0.57 1.49e-55 Blood protein levels; BRCA cis rs4919694 1.000 rs112809537 chr10:104670346 C/T cg04362960 chr10:104952993 NT5C2 0.98 15.23 0.52 6.73e-45 Arsenic metabolism; BRCA cis rs11112613 0.775 rs10507194 chr12:105959488 G/A cg03607813 chr12:105948248 NA 0.59 10.33 0.38 3.13e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg26818010 chr10:134567672 INPP5A -0.78 -15.61 -0.53 8.91e-47 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs17270561 0.609 rs9348695 chr6:25763010 A/T cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs490234 0.616 rs2648318 chr9:128163447 T/C cg14078157 chr9:128172775 NA -0.38 -9.04 -0.34 1.9e-18 Mean arterial pressure; BRCA cis rs1577917 1.000 rs12216328 chr6:86703418 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -7.83 -0.3 1.98e-14 Response to antipsychotic treatment; BRCA cis rs67072384 1.000 rs55957377 chr11:72445476 A/G cg04827223 chr11:72435913 ARAP1 -0.68 -11.14 -0.4 1.91e-26 Alloimmunization response to red blood cell transfusion in sickle cell anemia; BRCA cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg11266682 chr4:10021025 SLC2A9 -0.41 -11.09 -0.4 3.03e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg06212747 chr3:49208901 KLHDC8B 0.46 9.26 0.34 3.12e-19 Parkinson's disease; BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg08470875 chr2:26401718 FAM59B 0.58 9.2 0.34 4.99e-19 Gut microbiome composition (summer); BRCA cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.31 -0.31 5.55e-16 Aortic root size; BRCA cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg17845761 chr1:175162550 KIAA0040 -0.25 -9.29 -0.35 2.29e-19 Alcohol dependence; BRCA cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg23625390 chr15:77176239 SCAPER 0.4 9.25 0.34 3.36e-19 Blood metabolite levels; BRCA cis rs12478296 0.591 rs4973646 chr2:243001373 C/T cg06360820 chr2:242988706 NA 0.62 12.04 0.43 3.16e-30 Obesity-related traits; BRCA trans rs4650994 0.525 rs4076563 chr1:178516901 C/T cg05059571 chr16:84539110 KIAA1609 -0.58 -12.94 -0.46 3.37e-34 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg12564285 chr5:131593104 PDLIM4 0.37 9.83 0.36 2.41e-21 Breast cancer; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg22903471 chr2:27725779 GCKR -0.35 -8.52 -0.32 1.16e-16 Total body bone mineral density; BRCA cis rs250677 0.687 rs40522 chr5:148442295 G/A cg23229984 chr5:148520753 ABLIM3 0.35 8.64 0.32 4.48e-17 Breast cancer; BRCA cis rs2243480 0.901 rs778687 chr7:65835819 G/A cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA trans rs2204008 0.774 rs7305085 chr12:38263511 C/T cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs7975161 1.000 rs4964728 chr12:104649733 G/A cg25273343 chr12:104657179 TXNRD1 -0.51 -11.06 -0.4 3.93e-26 Toenail selenium levels; BRCA cis rs34526934 0.566 rs1374325 chr2:177043971 G/A cg26754761 chr2:177040938 NA -0.46 -9.0 -0.34 2.53e-18 Obstructive sleep apnea trait (apnea hypopnea index); BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.37 -0.41 2.08e-27 Gut microbiome composition (summer); BRCA trans rs208520 1.000 rs12200490 chr6:66976084 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.84 13.94 0.48 8.87e-39 Exhaled nitric oxide output; BRCA cis rs858239 0.539 rs6955969 chr7:23186699 C/T cg23682824 chr7:23144976 KLHL7 0.4 10.56 0.39 4e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs6456156 0.586 rs6909180 chr6:167460537 A/G cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.68e-21 Primary biliary cholangitis; BRCA cis rs1832871 0.711 rs76962726 chr6:158674041 C/T cg07165851 chr6:158734300 TULP4 0.62 12.8 0.45 1.55e-33 Height; BRCA cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -12.57 -0.45 1.61e-32 Hemoglobin concentration; BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg04944784 chr2:26401820 FAM59B -0.93 -16.97 -0.56 1.34e-53 Gut microbiome composition (summer); BRCA cis rs757081 0.667 rs17560341 chr11:17107163 C/T cg15432903 chr11:17409602 KCNJ11 -0.46 -8.62 -0.32 5.14e-17 Systolic blood pressure; BRCA cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.17 -0.34 6.56e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2404602 0.669 rs17464903 chr15:77195486 A/G cg26408565 chr15:76604113 ETFA -0.4 -8.62 -0.32 5.37e-17 Blood metabolite levels; BRCA cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.7 -0.5 2.33e-42 Hemoglobin concentration; BRCA cis rs6700896 0.931 rs10749755 chr1:66129530 C/T cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs3857067 0.806 rs12507575 chr4:95114920 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs4689388 0.926 rs6446480 chr4:6295565 C/T cg00701064 chr4:6280414 WFS1 0.68 17.57 0.57 1.15e-56 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1499972 0.941 rs73168388 chr3:117645824 C/T cg07612923 chr3:117604196 NA 0.6 8.11 0.31 2.61e-15 Schizophrenia; BRCA cis rs4499344 0.693 rs8106944 chr19:33097783 A/C cg22980127 chr19:33182716 NUDT19 -0.38 -7.91 -0.3 1.11e-14 Mean platelet volume; BRCA cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg26343298 chr8:95960752 TP53INP1 0.3 8.74 0.33 2.12e-17 Type 2 diabetes; BRCA cis rs600806 0.778 rs4970767 chr1:110015183 G/A cg20591472 chr1:110008990 SYPL2 0.31 7.9 0.3 1.25e-14 Intelligence (multi-trait analysis); BRCA cis rs208520 0.661 rs4710566 chr6:66848538 G/A cg07460842 chr6:66804631 NA -1.02 -20.1 -0.62 5.5e-70 Exhaled nitric oxide output; BRCA trans rs11165623 0.792 rs1125358 chr1:96971800 T/C cg10631902 chr5:14652156 NA -0.5 -15.88 -0.53 3.91e-48 Hip circumference;Waist circumference; BRCA cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg26408565 chr15:76604113 ETFA 0.49 10.76 0.39 6.29e-25 Blood metabolite levels; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg24642844 chr7:1081250 C7orf50 -0.89 -16.21 -0.54 9.83e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2070488 0.804 rs13092164 chr3:38458533 G/A cg24069376 chr3:38537580 EXOG 0.32 8.83 0.33 9.97e-18 Electrocardiographic conduction measures; BRCA cis rs1355223 0.525 rs7129533 chr11:34872292 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg18016565 chr1:150552671 MCL1 -0.42 -9.67 -0.36 9.71e-21 Tonsillectomy; BRCA cis rs8180040 1.000 rs11714294 chr3:47339723 G/A cg27129171 chr3:47204927 SETD2 -0.69 -16.58 -0.55 1.24e-51 Colorectal cancer; BRCA cis rs9880211 1.000 rs28811905 chr3:136252052 T/C cg21827317 chr3:136751795 NA -0.43 -7.86 -0.3 1.7e-14 Body mass index;Height; BRCA cis rs6815814 0.950 rs5743565 chr4:38805983 T/C cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg08493051 chr2:3487164 NA -0.44 -9.28 -0.34 2.7e-19 Neurofibrillary tangles; BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg04944784 chr2:26401820 FAM59B -0.68 -11.22 -0.41 8.4e-27 Gut microbiome composition (summer); BRCA trans rs3733585 0.736 rs4543113 chr4:10008305 G/A cg26043149 chr18:55253948 FECH 0.39 8.42 0.32 2.47e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg13393036 chr8:95962371 TP53INP1 -0.35 -8.52 -0.32 1.11e-16 Type 2 diabetes; BRCA cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg17971929 chr21:40555470 PSMG1 -0.49 -10.82 -0.39 3.54e-25 Menarche (age at onset); BRCA cis rs9296092 0.517 rs56043172 chr6:33522363 T/G cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.62 0.32 5.37e-17 Multiple sclerosis; BRCA trans rs7613875 0.600 rs2624826 chr3:50155468 T/G cg21659725 chr3:3221576 CRBN -0.35 -8.07 -0.3 3.61e-15 Body mass index; BRCA cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg26248373 chr2:1572462 NA -0.66 -15.34 -0.52 1.9e-45 IgG glycosylation; BRCA cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.42 -7.91 -0.3 1.17e-14 Colorectal cancer; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg00814883 chr7:100076585 TSC22D4 -0.49 -10.48 -0.38 8.35e-24 Platelet count; BRCA cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12756686 chr19:29218302 NA 0.57 10.98 0.4 8.46e-26 Methadone dose in opioid dependence; BRCA cis rs849141 0.925 rs1029534 chr7:28189083 T/G cg22892036 chr7:28189139 JAZF1 0.46 8.28 0.31 7.31e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg23583168 chr7:148888333 NA -0.96 -25.09 -0.7 3.35e-97 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13046373 0.562 rs12627602 chr21:32022924 G/A cg16812893 chr21:31813075 KRTAP15-1 0.37 9.29 0.34 2.49e-19 HDL cholesterol; BRCA cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg21361702 chr7:150065534 REPIN1 0.42 7.81 0.3 2.28e-14 Blood protein levels;Circulating chemerin levels; BRCA cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg05234568 chr11:5960015 NA -0.47 -9.45 -0.35 6.04e-20 DNA methylation (variation); BRCA cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg03146154 chr1:46216737 IPP 0.45 10.07 0.37 2.99e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6866344 0.697 rs11748497 chr5:178130012 C/G cg10224037 chr5:178157518 ZNF354A 0.76 16.01 0.53 9.84e-49 Neutrophil percentage of white cells; BRCA cis rs312274 0.515 rs1822598 chr12:41231443 A/G cg17827154 chr12:41323612 CNTN1 0.36 9.03 0.34 2.09e-18 Metabolite levels (X-11787); BRCA cis rs2204008 0.840 rs7957966 chr12:37953629 A/G cg26384229 chr12:38710491 ALG10B -0.57 -13.22 -0.46 1.88e-35 Bladder cancer; BRCA cis rs10739663 0.520 rs2819624 chr9:128156519 A/G cg14078157 chr9:128172775 NA -0.43 -10.25 -0.38 6.5e-23 Resting heart rate; BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00149659 chr3:10157352 C3orf10 0.78 13.55 0.47 5.8e-37 Alzheimer's disease; BRCA cis rs9816226 0.590 rs869401 chr3:185826546 G/A cg00760338 chr3:185826511 ETV5 0.57 12.4 0.44 8.35e-32 Obesity;Body mass index; BRCA cis rs1669338 0.588 rs7629889 chr3:3187643 C/T cg16797762 chr3:3221439 CRBN -0.58 -9.07 -0.34 1.46e-18 White matter integrity; BRCA cis rs4746818 0.892 rs2394505 chr10:70871598 A/G cg11621586 chr10:70884670 VPS26A -0.62 -12.03 -0.43 3.36e-30 Left atrial antero-posterior diameter; BRCA cis rs6973256 0.897 rs2911495 chr7:133331405 T/C cg07491979 chr7:133331646 EXOC4 -0.38 -8.77 -0.33 1.67e-17 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.04 0.62 1.11e-69 Platelet count; BRCA cis rs2549003 1.000 rs2070727 chr5:131820275 C/A cg02551604 chr5:131831745 NA -0.4 -14.94 -0.51 1.73e-43 Asthma (sex interaction); BRCA cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.36 -8.83 -0.33 1.04e-17 Personality dimensions; BRCA cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg05347473 chr6:146136440 FBXO30 -0.39 -7.9 -0.3 1.18e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs6547741 0.935 rs4666005 chr2:27855239 A/G cg27432699 chr2:27873401 GPN1 0.42 8.93 0.33 4.62e-18 Oral cavity cancer; BRCA trans rs3857536 0.674 rs9345798 chr6:66951331 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.95 -0.3 8.27e-15 Blood trace element (Cu levels); BRCA cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.23 -0.41 7.77e-27 Schizophrenia; BRCA cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.54 -0.32 9.47e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6426558 0.537 rs2102634 chr1:227324308 T/C cg10327440 chr1:227177885 CDC42BPA -0.47 -9.3 -0.35 2.13e-19 Neutrophil percentage of white cells; BRCA cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg16230307 chr14:35515116 FAM177A1 0.73 15.06 0.51 4.55e-44 Psoriasis; BRCA cis rs8017423 0.935 rs7154695 chr14:90795705 C/G cg04374321 chr14:90722782 PSMC1 0.71 18.51 0.59 1.5e-61 Mortality in heart failure; BRCA cis rs2980436 1 rs2980436 chr8:8092025 A/G cg15556689 chr8:8085844 FLJ10661 -0.59 -17.01 -0.56 7.96e-54 Schizophrenia; BRCA trans rs1493916 0.967 rs9953768 chr18:31399468 A/G cg15819921 chr19:927150 ARID3A -0.47 -8.98 -0.33 2.89e-18 Life satisfaction; BRCA cis rs4808199 0.948 rs8108647 chr19:19427623 A/G cg03709012 chr19:19516395 GATAD2A 0.98 18.55 0.59 8.85e-62 Nonalcoholic fatty liver disease; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.72 15.83 0.53 7.6e-48 Lymphocyte counts; BRCA cis rs10262624 0.528 rs5029444 chr7:23737795 T/C cg05804949 chr7:23719620 C7orf46 0.38 7.88 0.3 1.39e-14 Schizophrenia; BRCA cis rs875971 1.000 rs709595 chr7:65817333 G/C cg11764359 chr7:65958608 NA 0.79 19.35 0.61 5.48e-66 Aortic root size; BRCA cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg18357526 chr6:26021779 HIST1H4A 0.51 9.39 0.35 1.02e-19 Intelligence (multi-trait analysis); BRCA cis rs4803468 1.000 rs3810174 chr19:41904165 C/T cg09537434 chr19:41945824 ATP5SL -0.98 -24.01 -0.69 2.89e-91 Height; BRCA cis rs10489202 0.608 rs10918827 chr1:168077044 A/G cg24449463 chr1:168025552 DCAF6 0.46 15.34 0.52 1.96e-45 Schizophrenia; BRCA cis rs637571 0.565 rs633800 chr11:65638719 G/A cg26695010 chr11:65641043 EFEMP2 0.45 9.79 0.36 3.63e-21 Eosinophil percentage of white cells; BRCA cis rs2235642 0.750 rs1894649 chr16:1657284 C/G cg26528668 chr16:1614120 IFT140 0.35 7.88 0.3 1.4e-14 Coronary artery disease; BRCA cis rs9790314 0.560 rs1450521 chr3:161091237 C/A cg04691961 chr3:161091175 C3orf57 -0.46 -10.85 -0.39 2.66e-25 Morning vs. evening chronotype; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26314531 chr2:26401878 FAM59B -0.63 -10.77 -0.39 5.55e-25 Gut microbiome composition (summer); BRCA cis rs1003719 0.715 rs2835644 chr21:38545610 G/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg09469691 chr10:81107165 PPIF 0.44 9.5 0.35 4.16e-20 Height; BRCA cis rs208520 0.690 rs74707865 chr6:66717352 A/G cg07460842 chr6:66804631 NA 0.98 19.59 0.61 2.75e-67 Exhaled nitric oxide output; BRCA cis rs4308124 0.708 rs6749633 chr2:111988016 A/G cg04571233 chr2:111982156 NA 0.44 9.49 0.35 4.55e-20 Vitiligo; BRCA cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg11890956 chr21:40555474 PSMG1 0.99 22.83 0.67 8.23e-85 Cognitive function; BRCA cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg15212455 chr7:39170539 POU6F2 0.35 7.81 0.3 2.41e-14 IgG glycosylation; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg21280719 chr6:42927975 GNMT -0.33 -13.93 -0.48 1.01e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2836950 0.772 rs62222988 chr21:40569508 T/C cg11644478 chr21:40555479 PSMG1 -0.44 -8.49 -0.32 1.48e-16 Menarche (age at onset); BRCA cis rs10782582 0.609 rs6656501 chr1:76266126 A/C cg03433033 chr1:76189801 ACADM -0.38 -7.83 -0.3 2.1e-14 Daytime sleep phenotypes; BRCA cis rs561341 1.000 rs548957 chr17:30302411 G/A cg12193833 chr17:30244370 NA -0.54 -8.72 -0.33 2.47e-17 Hip circumference adjusted for BMI; BRCA cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg23933602 chr10:16859644 RSU1 0.57 9.12 0.34 9.77e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.58 0.39 3.22e-24 IgG glycosylation; BRCA cis rs4243830 1.000 rs12401795 chr1:6594773 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 0.91 14.15 0.49 1.02e-39 Body mass index; BRCA cis rs11608355 0.545 rs61941585 chr12:109905222 C/T cg05360138 chr12:110035743 NA 0.65 10.77 0.39 5.72e-25 Neuroticism; BRCA cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg26647111 chr11:31128758 NA -0.42 -9.48 -0.35 4.94e-20 Red blood cell count; BRCA cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg12573674 chr2:1569213 NA -0.55 -12.15 -0.43 1.01e-30 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4268898 0.662 rs17789375 chr2:24502554 G/T cg06627628 chr2:24431161 ITSN2 -0.69 -13.03 -0.46 1.34e-34 Asthma; BRCA cis rs1371867 0.846 rs1788204 chr8:101303936 C/T cg06002616 chr8:101225028 SPAG1 -0.34 -8.34 -0.31 4.47e-16 Atrioventricular conduction; BRCA cis rs8044868 0.586 rs2070937 chr16:72089740 A/G cg16558253 chr16:72132732 DHX38 -0.45 -10.74 -0.39 7.78e-25 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg11764359 chr7:65958608 NA -0.76 -16.74 -0.55 1.98e-52 Aortic root size; BRCA cis rs11711311 1.000 rs7622403 chr3:113472434 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.41 -10.86 -0.39 2.41e-25 IgG glycosylation; BRCA cis rs724568 0.509 rs10179159 chr2:67923516 T/C cg14046302 chr2:67939758 NA -0.37 -9.45 -0.35 6.37e-20 Major depressive disorder (broad); BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg26608667 chr7:1196370 ZFAND2A 0.37 8.3 0.31 6.03e-16 Longevity;Endometriosis; BRCA cis rs7772486 0.875 rs56181683 chr6:146286620 A/G cg23711669 chr6:146136114 FBXO30 -0.64 -14.56 -0.5 1.16e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs6546550 0.935 rs1531025 chr2:70055505 G/T cg02498382 chr2:70120550 SNRNP27 -0.51 -10.58 -0.39 3.1e-24 Prevalent atrial fibrillation; BRCA cis rs3820928 0.904 rs2217359 chr2:227759892 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.29 -0.31 6.84e-16 Pulmonary function; BRCA cis rs7737355 0.898 rs4706025 chr5:130913788 T/A cg06307176 chr5:131281290 NA 0.52 10.43 0.38 1.27e-23 Life satisfaction; BRCA cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA cis rs4718428 0.705 rs13231140 chr7:66361618 C/G cg12165864 chr7:66369176 NA -0.45 -10.26 -0.38 5.58e-23 Corneal structure; BRCA cis rs13082711 0.911 rs34307140 chr3:27467875 A/C cg02860705 chr3:27208620 NA 0.53 10.65 0.39 1.65e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6138458 0.828 rs6138466 chr20:24997137 A/G cg26195577 chr20:24973756 C20orf3 0.71 17.45 0.57 4.57e-56 Blood protein levels; BRCA trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.37 -0.38 2.13e-23 Intelligence (multi-trait analysis); BRCA cis rs798554 0.567 rs1182190 chr7:2869391 A/G cg18446336 chr7:2847575 GNA12 -0.34 -7.9 -0.3 1.19e-14 Height; BRCA cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg02175503 chr12:58329896 NA 0.41 7.87 0.3 1.47e-14 Intelligence (multi-trait analysis); BRCA cis rs1059312 0.932 rs4760592 chr12:129287149 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -15.18 -0.51 1.19e-44 Systemic lupus erythematosus; BRCA trans rs2736337 0.532 rs6998387 chr8:11293458 C/T cg15556689 chr8:8085844 FLJ10661 0.34 8.56 0.32 8.58e-17 Rheumatoid arthritis; BRCA cis rs7959452 0.535 rs11177577 chr12:69671791 C/T cg20891283 chr12:69753455 YEATS4 0.57 14.78 0.5 1.01e-42 Blood protein levels; BRCA cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg22467129 chr15:76604101 ETFA -0.48 -10.55 -0.39 4.11e-24 Blood metabolite levels; BRCA cis rs2288327 0.643 rs1559908 chr2:179336347 C/T cg11548914 chr2:179343871 FKBP7;PLEKHA3;MIR548N -0.5 -8.68 -0.32 3.23e-17 Atrial fibrillation; BRCA cis rs2294693 0.685 rs67525613 chr6:41008956 G/T cg14769373 chr6:40998127 UNC5CL -0.43 -8.04 -0.3 4.37e-15 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs586533 0.881 rs669212 chr11:99502265 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.06 0.3 3.65e-15 Depressive symptoms (multi-trait analysis); BRCA trans rs11098499 0.754 rs7672778 chr4:120248585 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.32 0.38 3.27e-23 Corneal astigmatism; BRCA cis rs6987853 0.712 rs56220385 chr8:42428862 A/T cg09913449 chr8:42400586 C8orf40 0.41 9.22 0.34 4.19e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg19077165 chr18:44547161 KATNAL2 -0.52 -11.28 -0.41 4.75e-27 Personality dimensions; BRCA cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.86 0.45 7.85e-34 Bipolar disorder; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg23711669 chr6:146136114 FBXO30 0.8 19.33 0.61 6.42e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs6495367 1.000 rs1007365 chr15:79379492 T/G cg17916960 chr15:79447300 NA 0.36 8.66 0.32 3.7e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg21747090 chr2:27597821 SNX17 -0.4 -8.76 -0.33 1.72e-17 Total body bone mineral density; BRCA cis rs73001065 0.636 rs28720066 chr19:19572220 G/T cg03709012 chr19:19516395 GATAD2A 1.01 15.28 0.52 3.85e-45 LDL cholesterol; BRCA cis rs12545109 0.800 rs973548 chr8:57416402 C/T cg09654669 chr8:57350985 NA -0.38 -8.4 -0.32 2.9e-16 Obesity-related traits; BRCA cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg26384229 chr12:38710491 ALG10B -0.51 -13.38 -0.47 3.56e-36 Morning vs. evening chronotype; BRCA cis rs7267979 0.934 rs2482913 chr20:25405086 T/A cg08601574 chr20:25228251 PYGB -0.38 -8.86 -0.33 7.62e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2625529 0.607 rs2912231 chr15:72567957 G/T cg16672083 chr15:72433130 SENP8 -0.76 -16.42 -0.54 7.84e-51 Red blood cell count; BRCA cis rs9790314 0.690 rs1599390 chr3:160833246 A/G cg03342759 chr3:160939853 NMD3 -0.53 -11.33 -0.41 3.02e-27 Morning vs. evening chronotype; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.92 0.6 1.05e-63 Alzheimer's disease; BRCA cis rs6429082 0.783 rs291385 chr1:235646613 T/C cg26050004 chr1:235667680 B3GALNT2 0.57 13.53 0.47 7.03e-37 Adiposity; BRCA cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.69 -0.36 8.4e-21 Menopause (age at onset); BRCA cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs11690935 0.959 rs7604918 chr2:172588094 G/A cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.79 -0.77 2.53e-128 Schizophrenia; BRCA cis rs7666738 0.830 rs13138059 chr4:99050430 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.38 0.57 1.03e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg23711669 chr6:146136114 FBXO30 0.8 19.39 0.61 3.15e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs801193 1.000 rs7785213 chr7:66138978 A/C cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.62e-43 Aortic root size; BRCA cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg06618935 chr21:46677482 NA -0.37 -8.12 -0.31 2.41e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg21782813 chr7:2030301 MAD1L1 0.43 12.38 0.44 1.09e-31 Bipolar disorder and schizophrenia; BRCA trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs11764590 0.694 rs2056477 chr7:2079744 G/C cg02951883 chr7:2050386 MAD1L1 0.38 7.81 0.3 2.28e-14 Neuroticism; BRCA cis rs10193935 0.605 rs10169492 chr2:42401961 G/T cg27598129 chr2:42591480 NA -0.94 -14.86 -0.51 4.13e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg12573674 chr2:1569213 NA -0.62 -14.09 -0.49 1.83e-39 IgG glycosylation; BRCA cis rs2806561 0.578 rs6702719 chr1:23302576 T/C cg19743168 chr1:23544995 NA 0.35 8.09 0.3 3.03e-15 Height; BRCA cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs3771570 0.901 rs35256094 chr2:242439938 A/C cg21155796 chr2:242212141 HDLBP 0.63 9.72 0.36 6.29e-21 Prostate cancer; BRCA cis rs16854884 0.789 rs34096668 chr3:143794483 C/T cg06585982 chr3:143692056 C3orf58 0.39 7.88 0.3 1.38e-14 Economic and political preferences (feminism/equality); BRCA cis rs4803468 0.967 rs3786553 chr19:41902746 T/G cg09537434 chr19:41945824 ATP5SL -0.98 -23.56 -0.68 8.11e-89 Height; BRCA cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg14530993 chr4:882597 GAK 0.59 9.66 0.36 1.04e-20 Intelligence (multi-trait analysis); BRCA trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.54 17.21 0.56 8.02e-55 Intelligence (multi-trait analysis); BRCA cis rs6754311 0.608 rs3739020 chr2:136602491 T/G cg07169764 chr2:136633963 MCM6 0.73 14.58 0.5 8.62e-42 Mosquito bite size; BRCA cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 17.29 0.56 3.05e-55 Hip circumference adjusted for BMI; BRCA cis rs589448 0.933 rs523398 chr12:69752775 C/T cg14784868 chr12:69753453 YEATS4 0.78 25.03 0.7 6.84e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg13319975 chr6:146136371 FBXO30 -0.62 -13.66 -0.48 1.86e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504073 0.584 rs11786103 chr8:49904077 A/G cg00325661 chr8:49890786 NA 0.47 13.98 0.48 5.83e-39 Blood metabolite ratios; BRCA cis rs858239 0.601 rs764534 chr7:23153935 C/T cg23682824 chr7:23144976 KLHL7 0.4 10.42 0.38 1.42e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.09 0.4 2.94e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs4596713 0.508 rs35490502 chr9:71747895 T/A cg16512924 chr15:28394682 HERC2 0.4 9.73 0.36 5.9e-21 Headache; BRCA cis rs6942756 1.000 rs2141075 chr7:128877305 C/T cg02491457 chr7:128862824 NA 0.72 14.77 0.5 1.08e-42 White matter hyperintensity burden; BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26314531 chr2:26401878 FAM59B -0.63 -10.82 -0.39 3.45e-25 Gut microbiome composition (summer); BRCA cis rs2070488 0.775 rs961179 chr3:38509618 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.65 0.57 4.28e-57 Electrocardiographic conduction measures; BRCA cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg26384229 chr12:38710491 ALG10B 0.76 16.99 0.56 1.04e-53 Morning vs. evening chronotype; BRCA cis rs6750795 0.518 rs1434519 chr2:232433761 A/G cg19187155 chr2:232395269 NMUR1 0.62 11.56 0.42 3.44e-28 Height; BRCA cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg00990874 chr7:1149470 C7orf50 -0.53 -9.51 -0.35 3.86e-20 Bronchopulmonary dysplasia; BRCA cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg01483505 chr11:975446 AP2A2 0.33 9.01 0.34 2.32e-18 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.41e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1420338 0.837 rs17753041 chr7:34176925 G/A cg01275685 chr7:34179230 BMPER -0.51 -11.34 -0.41 2.66e-27 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg15704280 chr7:45808275 SEPT13 0.81 19.61 0.61 2.25e-67 Coronary artery disease; BRCA cis rs7267979 0.966 rs2257705 chr20:25264664 T/C cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs3733585 0.673 rs4560411 chr4:9953361 A/G cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7572733 0.515 rs893808 chr2:198860837 C/G cg00792783 chr2:198669748 PLCL1 0.44 9.68 0.36 9.05e-21 Dermatomyositis; BRCA cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg11764359 chr7:65958608 NA -0.75 -16.65 -0.55 5.39e-52 Aortic root size; BRCA cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.61 16.17 0.54 1.47e-49 Electrocardiographic conduction measures; BRCA cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.5 7.93 0.3 9.47e-15 Renal function-related traits (BUN); BRCA cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -10.59 -0.39 2.92e-24 IgG glycosylation; BRCA cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg25801113 chr15:45476975 SHF -0.34 -8.33 -0.31 4.87e-16 Uric acid levels; BRCA cis rs1371614 0.632 rs3769134 chr2:27150891 A/G cg00617064 chr2:27272375 NA -0.3 -8.04 -0.3 4.24e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.63 -0.39 1.98e-24 Bone mineral density; BRCA cis rs3806843 0.966 rs10060640 chr5:140211226 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.84 -0.36 2.26e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs4595586 0.545 rs1349257 chr12:39397139 A/G cg26384229 chr12:38710491 ALG10B 0.41 9.29 0.34 2.48e-19 Morning vs. evening chronotype; BRCA cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg13271783 chr10:134563150 INPP5A 0.53 10.23 0.38 7.52e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs17270561 0.636 rs4360128 chr6:25734558 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.79 0.33 1.35e-17 Iron status biomarkers; BRCA cis rs7267979 0.933 rs2261109 chr20:25259200 T/C cg08601574 chr20:25228251 PYGB 0.36 8.72 0.33 2.4e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs2832077 0.943 rs4816336 chr21:30193519 C/T cg14791747 chr16:20752902 THUMPD1 0.4 9.41 0.35 8.7e-20 Cognitive test performance; BRCA cis rs1595825 0.891 rs57990618 chr2:198660838 C/T cg19156104 chr2:198669113 PLCL1 -0.48 -8.54 -0.32 9.79e-17 Ulcerative colitis; BRCA cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.7 0.36 7.74e-21 Menopause (age at onset); BRCA cis rs3796352 0.571 rs11713926 chr3:53155072 C/T cg07884673 chr3:53033167 SFMBT1 0.69 8.49 0.32 1.46e-16 Immune reponse to smallpox (secreted IL-2); BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg03354898 chr7:1950403 MAD1L1 0.38 8.55 0.32 9.37e-17 Bipolar disorder and schizophrenia; BRCA cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg02297831 chr4:17616191 MED28 0.38 8.88 0.33 6.9e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7607369 0.500 rs6712856 chr2:219658617 A/T cg02176678 chr2:219576539 TTLL4 -0.43 -11.41 -0.41 1.4e-27 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs8180040 0.871 rs11716661 chr3:47517773 G/T cg27129171 chr3:47204927 SETD2 -0.69 -16.1 -0.54 3.34e-49 Colorectal cancer; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg14820908 chr5:178986412 RUFY1 0.5 13.02 0.46 1.61e-34 Lung cancer; BRCA trans rs17685 0.753 rs3757593 chr7:75678735 G/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.81 -0.74 3.6e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg06784218 chr1:46089804 CCDC17 0.47 11.09 0.4 3e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg03433033 chr1:76189801 ACADM 0.58 11.49 0.41 6.74e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.55 -0.42 3.75e-28 Glomerular filtration rate (creatinine); BRCA cis rs12541635 0.677 rs61002083 chr8:106982132 A/G cg10147462 chr8:107024639 NA 0.41 10.96 0.4 1.01e-25 Age of smoking initiation; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg08888203 chr3:10149979 C3orf24 0.67 14.13 0.49 1.27e-39 Alzheimer's disease; BRCA cis rs6062302 0.522 rs6090475 chr20:62245397 C/A cg16989086 chr20:62203971 PRIC285 0.52 8.77 0.33 1.63e-17 Glioblastoma; BRCA cis rs4363385 0.818 rs2711 chr1:153005156 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg11279151 chr3:101281821 RG9MTD1 -0.5 -10.44 -0.38 1.14e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg27170947 chr2:26402098 FAM59B -0.94 -16.9 -0.56 3.15e-53 Gut microbiome composition (summer); BRCA cis rs6570726 0.935 rs453609 chr6:145812332 T/C cg23711669 chr6:146136114 FBXO30 0.63 14.75 0.5 1.31e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7264396 0.779 rs2425162 chr20:34429974 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.38 7.87 0.3 1.53e-14 Total cholesterol levels; BRCA cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.19 0.56 1.07e-54 Bladder cancer; BRCA cis rs6733011 0.578 rs12712039 chr2:99497980 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.31 -0.31 5.94e-16 Bipolar disorder; BRCA trans rs75804782 0.691 rs55886641 chr2:239319185 T/C cg01134436 chr17:81009848 B3GNTL1 0.77 9.69 0.36 8.3e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs6028335 0.610 rs67743908 chr20:37572643 G/A cg16355469 chr20:37678765 NA 0.44 8.07 0.3 3.62e-15 Alcohol and nicotine co-dependence; BRCA cis rs11098499 0.954 rs3890049 chr4:120326283 T/A cg09307838 chr4:120376055 NA 0.72 15.37 0.52 1.39e-45 Corneal astigmatism; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg02951883 chr7:2050386 MAD1L1 -0.54 -13.61 -0.47 3.15e-37 Bipolar disorder and schizophrenia; BRCA cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.76 -18.71 -0.59 1.35e-62 Systemic lupus erythematosus; BRCA cis rs2070488 0.775 rs4407366 chr3:38521425 C/T cg24069376 chr3:38537580 EXOG 0.3 8.24 0.31 9.84e-16 Electrocardiographic conduction measures; BRCA cis rs250677 0.687 rs250666 chr5:148454622 A/G cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.84e-31 Breast cancer; BRCA cis rs9296092 0.560 rs3846854 chr6:33528466 T/C cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs6087990 0.806 rs875041 chr20:31383530 C/T cg13636640 chr20:31349939 DNMT3B 0.64 19.49 0.61 9.05e-67 Ulcerative colitis; BRCA trans rs877282 0.898 rs11253339 chr10:759640 C/T cg22713356 chr15:30763199 NA 1.28 23.73 0.68 9.93e-90 Uric acid levels; BRCA cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11890956 chr21:40555474 PSMG1 -0.65 -14.64 -0.5 4.52e-42 Menarche (age at onset); BRCA cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 13.68 0.48 1.44e-37 Personality dimensions; BRCA cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg25237894 chr2:233734115 C2orf82 0.4 11.45 0.41 9.38e-28 Coronary artery disease; BRCA cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg17971929 chr21:40555470 PSMG1 0.79 18.36 0.59 9.14e-61 Cognitive function; BRCA cis rs7927592 0.913 rs12284933 chr11:68319489 G/A cg20283391 chr11:68216788 NA -0.46 -9.05 -0.34 1.68e-18 Total body bone mineral density; BRCA cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg23711669 chr6:146136114 FBXO30 0.73 16.47 0.55 4.82e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg14847009 chr1:175162515 KIAA0040 -0.24 -8.87 -0.33 7.24e-18 Alcohol dependence; BRCA cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12667521 chr19:29218732 NA 0.49 9.51 0.35 3.69e-20 Methadone dose in opioid dependence; BRCA cis rs36051895 0.664 rs4593605 chr9:5107278 C/A cg02405213 chr9:5042618 JAK2 -0.49 -8.81 -0.33 1.14e-17 Pediatric autoimmune diseases; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg05863683 chr7:1912471 MAD1L1 0.4 8.38 0.31 3.27e-16 Bipolar disorder and schizophrenia; BRCA cis rs919433 0.680 rs788021 chr2:198293691 T/C cg00792783 chr2:198669748 PLCL1 0.38 8.44 0.32 2.18e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10267417 0.603 rs10271293 chr7:19932427 A/G cg05791153 chr7:19748676 TWISTNB 0.42 7.91 0.3 1.11e-14 Night sleep phenotypes; BRCA cis rs12618769 0.625 rs78518453 chr2:99213899 T/C cg10123293 chr2:99228465 UNC50 0.44 8.69 0.32 3.15e-17 Bipolar disorder; BRCA cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg16339924 chr4:17578868 LAP3 -0.76 -19.16 -0.6 5.53e-65 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7944584 0.611 rs10838696 chr11:47363285 A/G cg03711944 chr11:47377212 SPI1 0.34 7.93 0.3 9.91e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs8062405 0.755 rs4788074 chr16:28593597 A/G cg16576597 chr16:28551801 NUPR1 -0.34 -9.31 -0.35 2.05e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10129255 0.500 rs8011115 chr14:107194530 T/C cg07958169 chr14:107095056 NA -0.37 -7.96 -0.3 7.64e-15 Kawasaki disease; BRCA cis rs870825 0.698 rs2696046 chr4:185599972 G/A cg04058563 chr4:185651563 MLF1IP -0.66 -11.83 -0.42 2.55e-29 Blood protein levels; BRCA trans rs853679 0.607 rs36101351 chr6:27943369 C/T cg06606381 chr12:133084897 FBRSL1 -0.89 -8.78 -0.33 1.44e-17 Depression; BRCA cis rs6964587 1.000 rs7789492 chr7:91668854 C/T cg17063962 chr7:91808500 NA 0.57 13.55 0.47 5.69e-37 Breast cancer; BRCA cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg16325326 chr1:53192061 ZYG11B -0.65 -16.18 -0.54 1.39e-49 Monocyte count; BRCA trans rs208520 0.690 rs4710564 chr6:66823478 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 17.37 0.57 1.26e-55 Exhaled nitric oxide output; BRCA cis rs4280164 0.943 rs2516564 chr14:24778643 C/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.46 -7.89 -0.3 1.31e-14 Parent of origin effect on language impairment (paternal); BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg03188948 chr7:1209495 NA 0.68 11.32 0.41 3.3699999999999996e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7131987 0.622 rs7294598 chr12:29531989 A/C cg09582351 chr12:29534625 ERGIC2 0.48 10.77 0.39 5.87e-25 QT interval; BRCA trans rs9858542 1.000 rs9822268 chr3:49719729 G/A cg21659725 chr3:3221576 CRBN -0.48 -10.29 -0.38 4.33e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg11301795 chr4:187892539 NA -0.29 -9.86 -0.36 1.99e-21 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg26384229 chr12:38710491 ALG10B 0.58 13.18 0.46 2.81e-35 Morning vs. evening chronotype; BRCA trans rs4718428 0.705 rs10267335 chr7:66403220 G/T cg18876405 chr7:65276391 NA 0.44 8.51 0.32 1.21e-16 Corneal structure; BRCA cis rs2835872 0.758 rs1787401 chr21:39038893 C/T cg06728970 chr21:39037746 KCNJ6 0.44 12.57 0.45 1.51e-32 Electroencephalographic traits in alcoholism; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg12419862 chr22:24373484 LOC391322 -0.69 -15.93 -0.53 2.38e-48 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs8114671 0.586 rs734111 chr20:33533736 A/C cg24642439 chr20:33292090 TP53INP2 0.41 7.98 0.3 6.92e-15 Height; BRCA trans rs4596713 0.508 rs13289984 chr9:71775047 A/C cg16512924 chr15:28394682 HERC2 0.45 10.58 0.39 3.12e-24 Headache; BRCA trans rs3733585 0.699 rs17245723 chr4:9962218 A/T cg26043149 chr18:55253948 FECH -0.37 -8.22 -0.31 1.12e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.830 rs991169 chr4:98928567 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg13073564 chr4:8508604 NA -0.43 -11.88 -0.43 1.57e-29 Response to antineoplastic agents; BRCA cis rs11098499 0.954 rs7681544 chr4:120411255 T/C cg09307838 chr4:120376055 NA 0.72 15.19 0.52 9.94e-45 Corneal astigmatism; BRCA cis rs1003719 0.715 rs7280251 chr21:38567911 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.5 -0.5 2.11e-41 Eye color traits; BRCA cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.66 -0.45 6.23e-33 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg18402987 chr7:1209562 NA 0.66 11.17 0.4 1.4e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs7618501 0.602 rs2526743 chr3:50115245 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.31 -0.35 2.08e-19 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.28 0.38 4.9e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6772849 0.805 rs13325747 chr3:128336023 G/A cg16766828 chr3:128327626 NA -0.37 -8.57 -0.32 7.67e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs72781680 0.898 rs72786278 chr2:24063243 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.04 0.34 1.86e-18 Lymphocyte counts; BRCA cis rs4642101 0.597 rs9839769 chr3:12821405 C/T cg24848339 chr3:12840334 CAND2 0.49 13.14 0.46 4.54e-35 QRS complex (12-leadsum); BRCA cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.52 11.51 0.41 5.53e-28 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs9790314 0.540 rs9844862 chr3:161076188 G/A cg04691961 chr3:161091175 C3orf57 -0.46 -10.84 -0.39 2.87e-25 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg06618935 chr21:46677482 NA -0.36 -7.98 -0.3 6.64e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs138549714 1 rs138549714 chr18:3220755 G/GT cg14944538 chr18:3220532 MYOM1 -0.66 -9.68 -0.36 9.35e-21 Brain volume in infants (white matter); BRCA cis rs9486715 0.867 rs9480700 chr6:96965056 A/G cg06623918 chr6:96969491 KIAA0776 0.9 25.81 0.71 3.73e-101 Headache; BRCA cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg06453172 chr10:134556979 INPP5A -0.49 -10.41 -0.38 1.49e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9811920 0.581 rs793468 chr3:99538346 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.32 0.31 5.23e-16 Axial length; BRCA cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg02466173 chr16:30829666 NA -0.49 -11.18 -0.4 1.21e-26 Dementia with Lewy bodies; BRCA cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg00290607 chr11:67383545 NA 0.52 11.71 0.42 7.67e-29 Mean corpuscular volume; BRCA cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg05283184 chr6:79620031 NA -0.43 -11.36 -0.41 2.37e-27 Intelligence (multi-trait analysis); BRCA cis rs7727544 0.709 rs441969 chr5:131702120 G/A cg24060327 chr5:131705240 SLC22A5 -0.48 -9.87 -0.36 1.81e-21 Blood metabolite levels; BRCA cis rs55986470 0.670 rs56313033 chr2:239346202 C/T cg18131467 chr2:239335373 ASB1 -0.62 -8.08 -0.3 3.22e-15 Chronotype; BRCA cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg06115741 chr20:33292138 TP53INP2 -0.38 -8.39 -0.31 3.15e-16 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs751728 0.717 rs3763260 chr6:33774070 C/T cg15252951 chr6:33757062 LEMD2 0.38 8.67 0.32 3.45e-17 Crohn's disease; BRCA cis rs1113500 0.862 rs2336129 chr1:108640669 A/G cg06207961 chr1:108661230 NA -0.44 -10.69 -0.39 1.24e-24 Growth-regulated protein alpha levels; BRCA cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.33e-67 Aortic root size; BRCA cis rs79976124 0.797 rs79522358 chr6:66641140 C/G cg07460842 chr6:66804631 NA 0.6 10.31 0.38 3.59e-23 Type 2 diabetes; BRCA cis rs172166 0.694 rs203877 chr6:28048624 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.04 0.3 4.45e-15 Cardiac Troponin-T levels; BRCA cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.68e-24 Motion sickness; BRCA cis rs3862030 0.720 rs1056744 chr10:104236687 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.45 -13.23 -0.46 1.65e-35 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg24675658 chr1:53192096 ZYG11B 0.66 14.55 0.5 1.3e-41 Monocyte count; BRCA cis rs7246657 0.678 rs2927740 chr19:38140966 A/G cg23950597 chr19:37808831 NA 0.5 8.72 0.33 2.37e-17 Coronary artery calcification; BRCA cis rs59698941 0.550 rs11748063 chr5:132200943 C/T cg14825688 chr5:132208181 LEAP2 -0.38 -8.82 -0.33 1.09e-17 Apolipoprotein A-IV levels; BRCA cis rs10789491 0.767 rs1595898 chr1:47193577 G/A cg15501359 chr1:47185051 KIAA0494 0.69 17.11 0.56 2.66e-54 Response to hepatitis C treatment; BRCA cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg15556689 chr8:8085844 FLJ10661 -0.43 -11.32 -0.41 3.36e-27 Systolic blood pressure; BRCA cis rs6598955 0.543 rs12125620 chr1:26552238 G/A cg12744634 chr1:26560303 CCDC21 0.3 7.86 0.3 1.58e-14 Obesity-related traits; BRCA cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg26597838 chr10:835615 NA 1.01 17.8 0.58 7.47e-58 Eosinophil percentage of granulocytes; BRCA cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.79 -0.33 1.37e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg09436375 chr6:42928200 GNMT -0.27 -10.09 -0.37 2.6e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 9.49 0.35 4.61e-20 Rheumatoid arthritis; BRCA cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg18016565 chr1:150552671 MCL1 0.34 8.01 0.3 5.52e-15 Tonsillectomy; BRCA trans rs11722228 0.522 rs77691548 chr4:10136115 T/G cg26043149 chr18:55253948 FECH 1.17 28.24 0.75 1.75e-114 Gout;Urate levels;Serum uric acid levels; BRCA cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg04450456 chr4:17643702 FAM184B -0.33 -9.4 -0.35 9.83e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg05347473 chr6:146136440 FBXO30 0.43 8.56 0.32 8.72e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg25427524 chr10:38739819 LOC399744 -0.68 -16.56 -0.55 1.72e-51 Extrinsic epigenetic age acceleration; BRCA cis rs2760061 0.626 rs1636192 chr1:228124688 A/G cg02753203 chr1:228287806 NA -0.58 -12.36 -0.44 1.24e-31 Diastolic blood pressure; BRCA cis rs523522 0.885 rs524735 chr12:121022099 T/C cg12219531 chr12:120966889 COQ5 0.55 11.6 0.42 2.28e-28 High light scatter reticulocyte count; BRCA cis rs6977660 0.660 rs10253753 chr7:19823032 A/G cg07541023 chr7:19748670 TWISTNB 0.53 9.27 0.34 2.77e-19 Thyroid stimulating hormone; BRCA cis rs9287719 0.967 rs9679581 chr2:10751736 G/A cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.7e-23 Prostate cancer; BRCA cis rs7824557 0.736 rs35392635 chr8:11164349 G/C cg21775007 chr8:11205619 TDH 0.61 11.82 0.42 2.7e-29 Retinal vascular caliber; BRCA cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg06634786 chr22:41940651 POLR3H -0.67 -11.79 -0.42 3.69e-29 Vitiligo; BRCA cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg18196295 chr10:418757 DIP2C 0.49 11.74 0.42 5.63e-29 Psychosis in Alzheimer's disease; BRCA cis rs2964802 0.505 rs6872243 chr5:10818337 C/T cg14521931 chr5:10832172 NA -0.58 -12.75 -0.45 2.56e-33 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs4812048 1.000 rs6070696 chr20:57597645 A/G cg14073986 chr20:57617431 SLMO2 0.47 8.04 0.3 4.28e-15 Mean platelet volume; BRCA cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg04398451 chr17:18023971 MYO15A -0.69 -14.93 -0.51 1.79e-43 Total body bone mineral density; BRCA cis rs2777491 0.872 rs7176588 chr15:41588872 C/T cg18705301 chr15:41695430 NDUFAF1 -0.59 -13.71 -0.48 1.05e-37 Ulcerative colitis; BRCA cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg19628046 chr18:33552617 C18orf21 0.52 9.9 0.36 1.35e-21 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4363385 0.818 rs1415965 chr1:153002750 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.83e-16 Inflammatory skin disease; BRCA cis rs9660992 0.762 rs1172129 chr1:205244972 T/A cg00857998 chr1:205179979 DSTYK 0.4 7.91 0.3 1.13e-14 Mean corpuscular volume;Mean platelet volume; BRCA cis rs9796 0.621 rs58109657 chr15:41471750 A/G cg18705301 chr15:41695430 NDUFAF1 0.37 8.1 0.31 2.85e-15 Menopause (age at onset); BRCA cis rs3008870 1.000 rs912797 chr1:67413478 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.82 0.67 8.71e-85 Lymphocyte percentage of white cells; BRCA cis rs4975709 0.610 rs6886669 chr5:1867830 T/C cg11168104 chr5:1857477 NA -0.32 -8.44 -0.32 2.21e-16 Cardiovascular disease risk factors; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg13628971 chr7:2884303 GNA12 0.46 9.18 0.34 5.82e-19 Height; BRCA cis rs6840258 1.000 rs72667752 chr4:87939531 G/A cg08197287 chr4:87952173 AFF1 -0.44 -8.56 -0.32 8.22e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs2235642 0.750 rs2755185 chr16:1645827 A/G cg26528668 chr16:1614120 IFT140 0.36 7.97 0.3 7.48e-15 Coronary artery disease; BRCA trans rs783540 0.967 rs34186444 chr15:83287500 A/G cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.43 -0.32 2.33e-16 Schizophrenia; BRCA cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg23625390 chr15:77176239 SCAPER 0.39 9.06 0.34 1.52e-18 Blood metabolite levels; BRCA cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg05283184 chr6:79620031 NA -0.37 -9.14 -0.34 8.13e-19 Intelligence (multi-trait analysis); BRCA cis rs12760731 0.720 rs12035174 chr1:178314311 A/T cg00404053 chr1:178313656 RASAL2 0.62 8.66 0.32 3.71e-17 Obesity-related traits; BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -11.76 -0.42 4.8e-29 Gut microbiome composition (summer); BRCA cis rs6582630 0.555 rs2090785 chr12:38424342 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.53 0.57 1.85e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 20.56 0.63 1.85e-72 Platelet count; BRCA cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg17366294 chr4:99064904 C4orf37 0.54 11.56 0.42 3.22e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs634534 0.591 rs688862 chr11:65733393 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.36 8.98 0.33 3.05e-18 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg14004847 chr7:1930337 MAD1L1 -0.41 -8.21 -0.31 1.2e-15 Bipolar disorder and schizophrenia; BRCA cis rs6570726 0.967 rs365515 chr6:145802833 C/T cg23711669 chr6:146136114 FBXO30 -0.62 -14.3 -0.49 1.86e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs11711311 1.000 rs921741 chr3:113444051 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -10.85 -0.39 2.82e-25 IgG glycosylation; BRCA cis rs2836633 0.929 rs8130434 chr21:40036243 C/T cg05519781 chr21:40033154 ERG -0.42 -8.95 -0.33 3.93e-18 Coronary artery disease; BRCA cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg15664640 chr17:80829946 TBCD -0.59 -10.71 -0.39 9.54e-25 Bone mineral accretion in asthma (oral corticosteroid dose interaction); BRCA cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg11764359 chr7:65958608 NA -0.76 -16.74 -0.55 1.98e-52 Aortic root size; BRCA trans rs6951245 1.000 rs1881123 chr7:1084706 C/T cg13565492 chr6:43139072 SRF -0.79 -11.0 -0.4 6.8e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4308124 0.708 rs28871990 chr2:111962441 G/A cg04571233 chr2:111982156 NA -0.45 -9.65 -0.36 1.2e-20 Vitiligo; BRCA cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg06636001 chr8:8085503 FLJ10661 -0.53 -11.88 -0.43 1.48e-29 Mood instability; BRCA cis rs7945705 0.791 rs7944560 chr11:8817276 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.44 9.36 0.35 1.37e-19 Hemoglobin concentration; BRCA cis rs6815814 0.699 rs11730390 chr4:38881414 T/C cg02016764 chr4:38805732 TLR1 -0.51 -7.97 -0.3 7.2e-15 Breast cancer; BRCA trans rs9944715 0.911 rs8090542 chr18:43771364 G/A cg01718231 chr17:29326311 RNF135 -0.41 -8.39 -0.32 3.19e-16 Red cell distribution width;Mean corpuscular volume; BRCA cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg01874867 chr7:94954059 PON1 -0.4 -8.17 -0.31 1.6e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs13136331 0.680 rs4440183 chr4:88653805 C/T cg12990093 chr4:88570587 DMP1 -0.4 -8.19 -0.31 1.38e-15 Sitting height ratio; BRCA cis rs7582180 0.614 rs4850931 chr2:101005145 C/T cg14675211 chr2:100938903 LONRF2 0.45 10.38 0.38 2.02e-23 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg20503657 chr10:835505 NA 1.33 21.49 0.65 1.64e-77 Eosinophil percentage of granulocytes; BRCA cis rs9818758 0.607 rs80170003 chr3:48951640 T/C cg00383909 chr3:49044727 WDR6 0.98 15.26 0.52 4.45e-45 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs12368653 0.591 rs1552842 chr12:58012163 A/G cg12615879 chr12:58013172 SLC26A10 -0.33 -9.04 -0.34 1.8e-18 Multiple sclerosis; BRCA cis rs17253792 0.908 rs9972177 chr14:56073206 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.87 0.3 1.48e-14 Putamen volume; BRCA cis rs68170813 0.559 rs75672288 chr7:107031549 G/C cg02696742 chr7:106810147 HBP1 -0.54 -8.73 -0.33 2.21e-17 Coronary artery disease; BRCA trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg03929089 chr4:120376271 NA -0.51 -9.91 -0.36 1.28e-21 HDL cholesterol; BRCA cis rs9393777 0.588 rs11967935 chr6:26560672 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.28 -8.03 -0.3 4.78e-15 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg22875332 chr1:76189707 ACADM 0.78 18.62 0.59 3.68e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg15017067 chr4:17643749 FAM184B 0.33 10.21 0.37 8.99e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10876993 0.749 rs703832 chr12:58024626 G/C cg18357645 chr12:58087776 OS9 0.43 11.52 0.41 4.9e-28 Celiac disease or Rheumatoid arthritis; BRCA trans rs208520 0.802 rs1342959 chr6:66883329 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -18.36 -0.59 9.01e-61 Exhaled nitric oxide output; BRCA cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg18357645 chr12:58087776 OS9 0.34 8.22 0.31 1.11e-15 Multiple sclerosis; BRCA cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg07828340 chr4:882639 GAK 1.06 14.13 0.49 1.18e-39 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg13902645 chr11:5959945 NA -0.44 -8.74 -0.33 2.05e-17 DNA methylation (variation); BRCA cis rs950776 0.593 rs588765 chr15:78865425 T/C cg06917634 chr15:78832804 PSMA4 -0.6 -13.52 -0.47 8.59e-37 Sudden cardiac arrest; BRCA cis rs911555 0.723 rs12894652 chr14:103926024 A/G cg24130564 chr14:104152367 KLC1 0.36 8.1 0.31 2.84e-15 Intelligence (multi-trait analysis); BRCA cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg16325326 chr1:53192061 ZYG11B 0.66 16.4 0.54 1.06e-50 Monocyte count; BRCA trans rs9650657 0.585 rs4841401 chr8:10489592 C/G cg08975724 chr8:8085496 FLJ10661 -0.46 -8.52 -0.32 1.15e-16 Neuroticism; BRCA trans rs941408 1.000 rs1076447 chr19:2792128 C/G cg22153745 chr1:153894579 GATAD2B -0.48 -9.28 -0.34 2.49e-19 Total cholesterol levels; BRCA cis rs9790314 0.875 rs7615592 chr3:160981548 A/C cg04691961 chr3:161091175 C3orf57 -0.58 -13.52 -0.47 8.2e-37 Morning vs. evening chronotype; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.59 9.98 0.37 6.53e-22 Gut microbiome composition (summer); BRCA trans rs9291683 0.609 rs3796836 chr4:10011345 A/G cg26043149 chr18:55253948 FECH 0.4 8.61 0.32 5.71e-17 Bone mineral density; BRCA cis rs6138458 0.847 rs56312312 chr20:24959386 C/A cg06937882 chr20:24974362 C20orf3 -0.46 -7.99 -0.3 6.28e-15 Blood protein levels; BRCA cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg12011299 chr4:100065546 ADH4 0.48 10.86 0.39 2.48e-25 Smoking initiation; BRCA cis rs7737355 0.947 rs31585 chr5:130999082 A/G cg06307176 chr5:131281290 NA 0.53 10.4 0.38 1.68e-23 Life satisfaction; BRCA cis rs11098499 0.618 rs28491261 chr4:120294900 C/A cg09307838 chr4:120376055 NA 0.74 15.96 0.53 1.74e-48 Corneal astigmatism; BRCA trans rs2018683 0.677 rs55718000 chr7:28975625 T/C cg19402173 chr7:128379420 CALU -0.42 -10.01 -0.37 5.3e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6750795 0.765 rs6742387 chr2:232354832 G/T cg19187155 chr2:232395269 NMUR1 0.7 16.77 0.55 1.42e-52 Height; BRCA cis rs6060717 0.536 rs3787173 chr20:34472105 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.08 -0.3 3.21e-15 Hip circumference adjusted for BMI; BRCA cis rs7523050 0.643 rs17621922 chr1:109404454 C/T cg08274380 chr1:109419600 GPSM2 0.94 13.57 0.47 4.9e-37 Fat distribution (HIV); BRCA trans rs4650994 0.905 rs12753251 chr1:178529898 G/A cg05059571 chr16:84539110 KIAA1609 -0.41 -9.43 -0.35 7.71e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs4363385 0.818 rs11205166 chr1:152988627 C/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.03 -0.34 1.95e-18 Inflammatory skin disease; BRCA cis rs752010 0.631 rs7515066 chr1:42076915 A/G cg06885757 chr1:42089581 HIVEP3 -0.39 -12.61 -0.45 9.83e-33 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs11690935 0.549 rs2129475 chr2:172916772 A/G cg13550731 chr2:172543902 DYNC1I2 0.54 13.6 0.47 3.6e-37 Schizophrenia; BRCA cis rs12545109 0.642 rs2055984 chr8:57418332 A/G cg09654669 chr8:57350985 NA -0.45 -8.31 -0.31 5.58e-16 Obesity-related traits; BRCA cis rs68170813 0.521 rs75035695 chr7:106818731 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.49 -0.32 1.47e-16 Coronary artery disease; BRCA cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg12698349 chr2:225449008 CUL3 -0.59 -13.02 -0.46 1.49e-34 IgE levels in asthmatics (D.p. specific); BRCA cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.44 0.32 2.13e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg25482853 chr8:67687455 SGK3 1.02 16.08 0.54 4.27e-49 Lung disease severity in cystic fibrosis; BRCA cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg20891283 chr12:69753455 YEATS4 0.71 20.79 0.64 1e-73 Blood protein levels; BRCA trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg20587970 chr11:113659929 NA -0.89 -16.5 -0.55 3.42e-51 Hip circumference adjusted for BMI; BRCA cis rs17601876 0.814 rs28520437 chr15:51553277 C/T cg19946085 chr15:51559439 CYP19A1 -0.38 -11.0 -0.4 6.61e-26 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs870825 0.616 rs7678900 chr4:185635249 A/G cg04058563 chr4:185651563 MLF1IP 0.74 16.78 0.55 1.27e-52 Blood protein levels; BRCA trans rs9951602 0.541 rs12454297 chr18:76654445 A/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.3 0.59 1.73e-60 Obesity-related traits; BRCA cis rs1865721 1.000 rs17283692 chr18:73193911 T/C cg26385618 chr18:73139727 C18orf62 -0.39 -9.0 -0.34 2.66e-18 Intelligence; BRCA cis rs11098499 0.754 rs12509621 chr4:120249660 T/C cg09307838 chr4:120376055 NA 0.64 14.09 0.49 1.94e-39 Corneal astigmatism; BRCA cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.2 0.41 1.03e-26 Bipolar disorder; BRCA cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.65 -0.45 6.8e-33 Bipolar disorder; BRCA cis rs7903847 0.642 rs10882923 chr10:99159018 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.86 -0.33 7.98e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg01939980 chr4:1354348 KIAA1530 0.29 7.96 0.3 7.95e-15 Obesity-related traits; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.89 0.56 3.63e-53 Gut microbiome composition (summer); BRCA cis rs72720396 0.789 rs12048450 chr1:91199660 G/A cg13456504 chr1:91191583 NA 0.54 10.0 0.37 5.55e-22 Morning vs. evening chronotype;Chronotype; BRCA cis rs911119 1.000 rs3827142 chr20:23617007 G/A cg16589663 chr20:23618590 CST3 0.47 8.72 0.33 2.36e-17 Chronic kidney disease; BRCA cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg24692254 chr21:30365293 RNF160 -0.37 -8.23 -0.31 1.05e-15 Selective IgA deficiency; BRCA cis rs912057 0.671 rs1294427 chr6:6744546 T/G cg06612196 chr6:6737390 NA 0.46 10.85 0.39 2.81e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 14.15 0.49 9.42e-40 Alzheimer's disease; BRCA trans rs7939886 0.920 rs11227212 chr11:55873334 A/G cg15704280 chr7:45808275 SEPT13 0.61 7.93 0.3 1.01e-14 Myopia (pathological); BRCA cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg03060546 chr3:49711283 APEH 0.6 9.96 0.37 8.39e-22 Menarche (age at onset); BRCA cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg06784218 chr1:46089804 CCDC17 0.51 12.48 0.44 4.02e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg12419862 chr22:24373484 LOC391322 -0.69 -15.73 -0.53 2.35e-47 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1577917 0.545 rs9294338 chr6:86474368 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.34 9.22 0.34 4.23e-19 Response to antipsychotic treatment; BRCA cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA trans rs1994135 0.692 rs1579909 chr12:33694780 T/C cg26384229 chr12:38710491 ALG10B 0.39 8.59 0.32 6.67e-17 Resting heart rate; BRCA cis rs7786877 0.723 rs7812235 chr7:100211486 G/C cg16850897 chr7:100343110 ZAN -0.57 -10.63 -0.39 2.09e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1865760 0.566 rs3752419 chr6:26027433 C/T cg17691542 chr6:26056736 HIST1H1C 0.53 11.28 0.41 4.82e-27 Height; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg11843238 chr5:131593191 PDLIM4 0.36 9.24 0.34 3.66e-19 Breast cancer; BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg08470875 chr2:26401718 FAM59B -0.51 -8.53 -0.32 1.06e-16 Gut microbiome composition (summer); BRCA cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg20294984 chr1:43412752 SLC2A1 -0.5 -8.03 -0.3 4.8e-15 Monocyte count; BRCA cis rs733592 0.931 rs765260 chr12:48431936 C/T cg24011408 chr12:48396354 COL2A1 -0.44 -9.42 -0.35 7.98e-20 Plateletcrit; BRCA cis rs1595825 0.786 rs73054839 chr2:198671665 C/A cg19156104 chr2:198669113 PLCL1 -0.44 -8.27 -0.31 7.86e-16 Ulcerative colitis; BRCA cis rs2075371 0.863 rs34231360 chr7:133944988 A/C cg11752832 chr7:134001865 SLC35B4 0.51 11.84 0.42 2.27e-29 Mean platelet volume; BRCA cis rs61931739 0.534 rs11052991 chr12:34059018 G/T cg06521331 chr12:34319734 NA 0.62 11.88 0.43 1.47e-29 Morning vs. evening chronotype; BRCA cis rs473651 0.692 rs579511 chr2:239334914 C/G cg03560586 chr2:239334908 ASB1 -0.5 -10.92 -0.4 1.43e-25 Multiple system atrophy; BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.59 -10.38 -0.38 1.89e-23 Gut microbiome composition (summer); BRCA cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg27535305 chr1:53392650 SCP2 -0.38 -8.41 -0.32 2.68e-16 Monocyte count; BRCA cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg08213375 chr14:104286397 PPP1R13B -0.64 -17.83 -0.58 5.23e-58 Schizophrenia; BRCA trans rs526821 0.553 rs519637 chr11:55295935 A/T cg15704280 chr7:45808275 SEPT13 -0.42 -7.91 -0.3 1.15e-14 Pediatric bone mineral density (spine); BRCA cis rs453301 0.606 rs6601279 chr8:8908231 G/A cg15556689 chr8:8085844 FLJ10661 -0.35 -9.11 -0.34 1.01e-18 Joint mobility (Beighton score); BRCA cis rs6547741 0.717 rs2178197 chr2:27860551 C/T cg27432699 chr2:27873401 GPN1 0.48 10.32 0.38 3.39e-23 Oral cavity cancer; BRCA cis rs10752881 0.743 rs10737244 chr1:183098417 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Colorectal cancer; BRCA cis rs634534 0.622 rs501353 chr11:65739549 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 11.15 0.4 1.67e-26 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.03 0.3 4.62e-15 Tonsillectomy; BRCA cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg21017887 chr14:105400489 NA 0.66 17.41 0.57 7.56e-56 Rheumatoid arthritis; BRCA cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg13256891 chr4:100009986 ADH5 0.4 8.34 0.31 4.42e-16 Alcohol dependence; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs2901460 0.509 rs11677509 chr2:62045191 T/G cg02183531 chr2:62113199 CCT4 -0.45 -8.43 -0.32 2.38e-16 Mean corpuscular volume; BRCA trans rs11098499 0.863 rs6833334 chr4:120504227 C/T cg25214090 chr10:38739885 LOC399744 0.54 11.8 0.42 3.21e-29 Corneal astigmatism; BRCA cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg08807101 chr21:30365312 RNF160 0.43 8.92 0.33 4.92e-18 Pancreatic cancer; BRCA cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg05234568 chr11:5960015 NA -0.52 -10.35 -0.38 2.52e-23 DNA methylation (variation); BRCA cis rs2839186 1.000 rs2839186 chr21:47690068 C/T cg12379764 chr21:47803548 PCNT -0.39 -8.36 -0.31 3.9e-16 Testicular germ cell tumor; BRCA cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg22800045 chr5:56110881 MAP3K1 0.65 12.51 0.44 2.71e-32 Initial pursuit acceleration; BRCA cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg10295955 chr4:187884368 NA 0.95 28.22 0.74 2.28e-114 Lobe attachment (rater-scored or self-reported); BRCA cis rs17376456 0.877 rs67066109 chr5:93494101 G/C cg21475434 chr5:93447410 FAM172A 0.67 8.73 0.33 2.19e-17 Diabetic retinopathy; BRCA cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.42 0.54 8.67e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs1005277 0.579 rs2472174 chr10:38375382 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.19 -0.4 1.19e-26 Extrinsic epigenetic age acceleration; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg04267008 chr7:1944627 MAD1L1 -0.6 -13.41 -0.47 2.75e-36 Bipolar disorder and schizophrenia; BRCA cis rs826838 0.834 rs826874 chr12:39122599 C/A cg26384229 chr12:38710491 ALG10B -0.54 -14.15 -0.49 9.26e-40 Heart rate; BRCA cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg01262667 chr19:19385393 TM6SF2 0.34 8.76 0.33 1.71e-17 Tonsillectomy; BRCA cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg12311346 chr5:56204834 C5orf35 -0.82 -16.7 -0.55 3.35e-52 Initial pursuit acceleration; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg04025307 chr7:1156635 C7orf50 0.38 8.87 0.33 7.51e-18 Longevity;Endometriosis; BRCA cis rs701145 0.556 rs357502 chr3:153955950 C/T cg12800244 chr3:153838788 SGEF 0.44 8.79 0.33 1.36e-17 Coronary artery disease; BRCA cis rs1577917 1.000 rs35419329 chr6:86702291 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.19 -0.46 2.51e-35 Response to antipsychotic treatment; BRCA trans rs11098499 0.588 rs6534149 chr4:120559292 T/G cg25214090 chr10:38739885 LOC399744 -0.4 -9.08 -0.34 1.37e-18 Corneal astigmatism; BRCA cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg00631329 chr6:26305371 NA -0.44 -13.0 -0.46 1.8e-34 Educational attainment; BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg21143896 chr7:2802374 GNA12 -0.38 -9.49 -0.35 4.44e-20 Height; BRCA cis rs11190604 1.000 rs28522614 chr10:102323141 T/A cg07080220 chr10:102295463 HIF1AN 0.6 13.77 0.48 5.6e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2637030 0.559 rs2607497 chr5:52995482 A/G cg06476337 chr5:52856530 NDUFS4 0.35 7.99 0.3 6.23e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs3849570 0.925 rs9841087 chr3:81907949 A/G cg07356753 chr3:81810745 GBE1 -0.43 -10.11 -0.37 2.25e-22 Waist circumference;Body mass index; BRCA cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg04455712 chr21:45112962 RRP1B 0.4 10.54 0.38 4.6e-24 Mean corpuscular volume; BRCA cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg24692254 chr21:30365293 RNF160 -0.6 -15.07 -0.51 3.75e-44 Dental caries; BRCA cis rs1401999 0.898 rs4148561 chr3:183726379 A/G cg20387954 chr3:183756860 HTR3D 0.46 10.31 0.38 3.78e-23 Anterior chamber depth; BRCA cis rs2115630 1.000 rs11073730 chr15:85354596 C/T cg11189052 chr15:85197271 WDR73 -0.34 -8.01 -0.3 5.36e-15 P wave terminal force; BRCA cis rs2637266 1.000 rs10219023 chr10:78364537 G/A cg18941641 chr10:78392320 NA 0.35 7.83 0.3 1.97e-14 Pulmonary function; BRCA cis rs6750047 0.585 rs4670235 chr2:38272528 C/T cg07380506 chr2:38303506 CYP1B1 0.47 10.39 0.38 1.76e-23 Cutaneous malignant melanoma;Melanoma; BRCA cis rs416603 0.967 rs11644184 chr16:11365104 G/A cg00044050 chr16:11439710 C16orf75 -0.44 -10.22 -0.37 8.5e-23 Type 1 diabetes; BRCA cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg02297831 chr4:17616191 MED28 0.39 8.51 0.32 1.22e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8180040 0.966 rs13079098 chr3:47442863 A/G cg16586182 chr3:47516702 SCAP -0.63 -14.73 -0.5 1.79e-42 Colorectal cancer; BRCA cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg02574844 chr11:5959923 NA -0.43 -8.42 -0.32 2.55e-16 DNA methylation (variation); BRCA cis rs4965272 1.000 rs1585933 chr15:100585715 A/G cg27344315 chr15:100560801 ADAMTS17 -0.38 -7.85 -0.3 1.73e-14 Gastroesophageal reflux disease; BRCA cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg04450456 chr4:17643702 FAM184B 0.36 10.45 0.38 1.05e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs589448 1.000 rs589448 chr12:69752200 A/G cg14784868 chr12:69753453 YEATS4 0.78 25.0 0.7 9.83e-97 Cerebrospinal fluid biomarker levels; BRCA trans rs6598955 0.617 rs11247895 chr1:26599542 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg24642439 chr20:33292090 TP53INP2 0.55 12.25 0.44 3.96e-31 Glomerular filtration rate (creatinine); BRCA cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg18351406 chr4:77819688 ANKRD56 0.58 12.6 0.45 1.14e-32 Emphysema distribution in smoking; BRCA cis rs11634851 0.844 rs4778849 chr15:81026226 C/T cg03950166 chr15:80988613 FAM108C1 -0.33 -8.0 -0.3 5.99e-15 Systolic blood pressure; BRCA cis rs9486719 0.948 rs2499817 chr6:96878321 C/T cg06623918 chr6:96969491 KIAA0776 0.73 12.95 0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs568617 0.626 rs10896050 chr11:65577516 G/T cg04055107 chr11:65626734 MUS81;CFL1 0.57 9.26 0.34 2.97e-19 Crohn's disease; BRCA cis rs428668 0.523 rs6898671 chr5:150677643 A/T cg11125805 chr5:150678162 SLC36A3 0.73 19.48 0.61 1.03e-66 Skin aging (microtopography measurement); BRCA cis rs6743226 0.934 rs6705421 chr2:242212672 A/G cg10021735 chr2:242295487 FARP2 0.37 10.02 0.37 4.92e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg13010199 chr12:38710504 ALG10B 0.55 12.23 0.44 4.72e-31 Heart rate; BRCA cis rs3820928 0.874 rs3752895 chr2:227886773 A/G cg11843606 chr2:227700838 RHBDD1 -0.37 -8.28 -0.31 6.97e-16 Pulmonary function; BRCA trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.6 0.36 1.8e-20 Morning vs. evening chronotype; BRCA cis rs798554 0.704 rs709282 chr7:2769921 G/A cg18446336 chr7:2847575 GNA12 -0.35 -8.11 -0.31 2.61e-15 Height; BRCA cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg24562669 chr7:97807699 LMTK2 0.43 11.46 0.41 8.48e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs7191700 0.509 rs415595 chr16:11363692 A/G cg00044050 chr16:11439710 C16orf75 0.35 8.11 0.31 2.5e-15 Multiple sclerosis; BRCA cis rs4588572 0.643 rs1864172 chr5:77690945 T/C cg11547950 chr5:77652471 NA 0.44 7.82 0.3 2.21e-14 Triglycerides; BRCA cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg19731401 chr7:2775893 GNA12 0.52 8.19 0.31 1.45e-15 Childhood ear infection; BRCA cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg19678392 chr7:94953810 PON1 -0.41 -8.73 -0.33 2.17e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs7647973 0.677 rs11130211 chr3:49645209 C/T cg21659725 chr3:3221576 CRBN -0.47 -8.46 -0.32 1.86e-16 Menarche (age at onset); BRCA cis rs6964587 0.677 rs62467839 chr7:91967371 A/G cg17063962 chr7:91808500 NA 0.52 11.37 0.41 2.03e-27 Breast cancer; BRCA cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg13852791 chr20:30311386 BCL2L1 0.84 16.5 0.55 3.24e-51 Mean corpuscular hemoglobin; BRCA cis rs9640161 0.750 rs11764936 chr7:150025915 G/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.56 -13.78 -0.48 5.26e-38 Blood protein levels;Circulating chemerin levels; BRCA cis rs3858526 0.834 rs7128847 chr11:6003111 C/T cg05234568 chr11:5960015 NA -0.46 -9.25 -0.34 3.2e-19 DNA methylation (variation); BRCA cis rs9309711 0.961 rs35067331 chr2:3474085 C/T cg16153549 chr2:3496821 NA -0.37 -8.2 -0.31 1.34e-15 Neurofibrillary tangles; BRCA cis rs1997103 1.000 rs2177805 chr7:55404381 T/A cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg21724239 chr8:58056113 NA 0.56 9.08 0.34 1.3e-18 Developmental language disorder (linguistic errors); BRCA cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.97e-68 Blood protein levels; BRCA cis rs875971 0.862 rs4718330 chr7:65715243 G/A cg18876405 chr7:65276391 NA -0.51 -11.62 -0.42 1.85e-28 Aortic root size; BRCA cis rs600806 0.813 rs4970759 chr1:109982213 C/A cg20591472 chr1:110008990 SYPL2 0.32 7.85 0.3 1.8e-14 Intelligence (multi-trait analysis); BRCA cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22455342 chr2:225449267 CUL3 0.68 17.33 0.57 1.97e-55 IgE levels in asthmatics (D.p. specific); BRCA cis rs1949733 0.523 rs56053534 chr4:8542876 G/A cg11789530 chr4:8429930 ACOX3 -0.55 -12.62 -0.45 8.99e-33 Response to antineoplastic agents; BRCA cis rs6840360 0.615 rs12647616 chr4:152607662 G/A cg22705602 chr4:152727874 NA -0.37 -10.01 -0.37 5.1e-22 Intelligence (multi-trait analysis); BRCA cis rs9486715 0.758 rs2971610 chr6:97027380 C/T cg06623918 chr6:96969491 KIAA0776 -0.93 -27.35 -0.73 1.21e-109 Headache; BRCA cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg04546413 chr19:29218101 NA 0.49 8.44 0.32 2.17e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 0.932 rs417110 chr20:25458297 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.85 0.33 8.73e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs921968 0.565 rs12694439 chr2:219590871 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.94e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs2882667 0.690 rs851278 chr5:138103266 A/G cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg17971929 chr21:40555470 PSMG1 0.77 18.09 0.58 2.17e-59 Cognitive function; BRCA cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA trans rs4596713 0.507 rs10115134 chr9:71800562 T/C cg16512924 chr15:28394682 HERC2 0.45 10.67 0.39 1.44e-24 Headache; BRCA cis rs11098499 0.954 rs10017371 chr4:120293776 A/G cg09307838 chr4:120376055 NA 0.71 14.74 0.5 1.46e-42 Corneal astigmatism; BRCA cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg11764359 chr7:65958608 NA 0.8 19.2 0.6 3.43e-65 Aortic root size; BRCA cis rs1215050 0.791 rs7688942 chr4:98832048 T/C cg05340658 chr4:99064831 C4orf37 0.44 10.2 0.37 1e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg26944245 chr16:421049 TMEM8A;MRPL28 0.51 12.23 0.44 4.75e-31 Bone mineral density (spine);Bone mineral density; BRCA cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg06108461 chr20:60628389 TAF4 -0.99 -22.27 -0.66 9.76e-82 Body mass index; BRCA cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg18876405 chr7:65276391 NA 0.55 12.97 0.46 2.45e-34 Aortic root size; BRCA cis rs4631830 0.863 rs2611489 chr10:51524889 C/T cg20129853 chr10:51489980 NA -0.29 -7.94 -0.3 9.36e-15 Prostate-specific antigen levels; BRCA cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg04546413 chr19:29218101 NA 0.64 12.26 0.44 3.55e-31 Methadone dose in opioid dependence; BRCA cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.32 0.57 2.11e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs12477438 0.520 rs11678456 chr2:99708237 G/A cg08885076 chr2:99613938 TSGA10 0.45 10.6 0.39 2.78e-24 Chronic sinus infection; BRCA cis rs40363 0.645 rs250633 chr16:3523002 C/T cg05754148 chr16:3507555 NAT15 0.37 7.84 0.3 1.86e-14 Tuberculosis; BRCA cis rs12760731 0.565 rs10913519 chr1:178196094 A/T cg00404053 chr1:178313656 RASAL2 0.65 7.85 0.3 1.82e-14 Obesity-related traits; BRCA cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg08000102 chr2:233561755 GIGYF2 0.61 13.08 0.46 8.04e-35 Coronary artery disease; BRCA cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg19678392 chr7:94953810 PON1 -0.41 -8.45 -0.32 2.04e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs11603020 0.950 rs11229066 chr11:57374871 C/G cg19752551 chr11:57585705 CTNND1 -0.41 -9.63 -0.36 1.41e-20 Blood protein levels; BRCA cis rs7474896 0.559 rs1779075 chr10:38167530 C/G cg25427524 chr10:38739819 LOC399744 0.59 11.08 0.4 3.27e-26 Obesity (extreme); BRCA cis rs77861329 1.000 rs9847073 chr3:52144947 C/T cg08692210 chr3:52188851 WDR51A -0.71 -10.62 -0.39 2.33e-24 Macrophage inflammatory protein 1b levels; BRCA trans rs11165623 0.792 rs13375510 chr1:96920723 A/G cg10631902 chr5:14652156 NA -0.5 -16.07 -0.54 4.66e-49 Hip circumference;Waist circumference; BRCA cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg20503657 chr10:835505 NA 1.03 17.95 0.58 1.18e-58 Eosinophil percentage of granulocytes; BRCA cis rs7766436 0.885 rs6935379 chr6:22581462 A/G cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA cis rs965469 0.843 rs6037580 chr20:3351374 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.54 -0.38 4.61e-24 IFN-related cytopenia; BRCA cis rs210142 1.000 rs210142 chr6:33546837 T/C cg24505687 chr6:33548425 BAK1 0.57 12.15 0.43 1e-30 Platelet count;Plateletcrit;Chronic lymphocytic leukemia; BRCA cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.34 0.47 5.43e-36 Mean platelet volume; BRCA cis rs2404602 0.647 rs11852395 chr15:77087785 T/C cg23625390 chr15:77176239 SCAPER -0.55 -12.92 -0.46 4.26e-34 Blood metabolite levels; BRCA cis rs950776 0.518 rs3813571 chr15:78832792 G/T cg22563815 chr15:78856949 CHRNA5 0.36 8.39 0.31 3.14e-16 Sudden cardiac arrest; BRCA cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg13319975 chr6:146136371 FBXO30 -0.6 -13.56 -0.47 5.14e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg04166393 chr7:2884313 GNA12 0.54 10.1 0.37 2.32e-22 Height; BRCA cis rs17209837 0.607 rs2072384 chr7:87082868 A/T cg00919237 chr7:87102261 ABCB4 -0.53 -10.24 -0.38 6.94e-23 Gallbladder cancer; BRCA trans rs7647973 0.626 rs1586827 chr3:49671224 T/C cg21659725 chr3:3221576 CRBN -0.47 -8.33 -0.31 5.12e-16 Menarche (age at onset); BRCA cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg22875332 chr1:76189707 ACADM -0.54 -10.3 -0.38 4.18e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs870825 0.860 rs34985821 chr4:185599489 G/A cg04058563 chr4:185651563 MLF1IP 0.85 14.24 0.49 3.6e-40 Blood protein levels; BRCA cis rs4819052 0.851 rs2838832 chr21:46664904 A/G cg11663144 chr21:46675770 NA 0.58 13.66 0.48 1.93e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs34779708 0.898 rs4934695 chr10:35280605 C/T cg03585969 chr10:35415529 CREM 0.56 11.51 0.41 5.36e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.46 0.38 9.2e-24 IgG glycosylation; BRCA cis rs3087591 0.879 rs59015798 chr17:29580882 G/A cg24425628 chr17:29625626 OMG;NF1 -0.4 -7.81 -0.3 2.42e-14 Hip circumference; BRCA cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg24692254 chr21:30365293 RNF160 0.63 14.48 0.5 2.76e-41 Selective IgA deficiency; BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24549020 chr5:56110836 MAP3K1 -0.62 -12.69 -0.45 4.57e-33 Initial pursuit acceleration; BRCA cis rs778371 0.697 rs11893358 chr2:233636922 T/C cg08000102 chr2:233561755 GIGYF2 0.82 19.37 0.61 4.01e-66 Schizophrenia; BRCA cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg22875332 chr1:76189707 ACADM -0.66 -13.89 -0.48 1.68e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6456156 0.586 rs12528323 chr6:167461645 A/G cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.68e-21 Primary biliary cholangitis; BRCA cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs1493916 0.905 rs4239383 chr18:31401066 T/C cg15819921 chr19:927150 ARID3A -0.51 -9.68 -0.36 9.27e-21 Life satisfaction; BRCA cis rs6973256 0.865 rs2991230 chr7:133332086 A/C cg07491979 chr7:133331646 EXOC4 -0.38 -8.71 -0.33 2.51e-17 Intelligence (multi-trait analysis); BRCA cis rs1691799 0.899 rs1060724 chr12:66740444 T/C cg16791601 chr12:66731901 HELB -0.65 -17.57 -0.57 1.16e-56 White blood cell count (basophil); BRCA cis rs2108225 0.967 rs6466189 chr7:107448516 C/T cg18560240 chr7:107437656 SLC26A3 -0.5 -10.35 -0.38 2.54e-23 Ulcerative colitis; BRCA cis rs2806561 0.765 rs2776815 chr1:23510584 C/T cg12483005 chr1:23474871 LUZP1 -0.46 -10.4 -0.38 1.61e-23 Height; BRCA cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg23711669 chr6:146136114 FBXO30 0.73 17.52 0.57 2.06e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 8.54 0.32 1.01e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1451375 0.741 rs55738142 chr7:50632326 T/C cg18232548 chr7:50535776 DDC 0.4 9.43 0.35 7.21e-20 Malaria; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -7.82 -0.3 2.13e-14 Developmental language disorder (linguistic errors); BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03576123 chr11:487126 PTDSS2 -1.2 -18.77 -0.6 6.11e-63 Body mass index; BRCA cis rs4642101 0.597 rs9839768 chr3:12821403 C/T cg05775895 chr3:12838266 CAND2 0.38 8.49 0.32 1.44e-16 QRS complex (12-leadsum); BRCA cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg06028605 chr16:24865363 SLC5A11 -0.46 -10.11 -0.37 2.19e-22 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg08000102 chr2:233561755 GIGYF2 0.65 14.11 0.49 1.47e-39 Coronary artery disease; BRCA cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs7598759 0.675 rs6727530 chr2:232332058 T/C cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.1e-14 Noise-induced hearing loss; BRCA cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg10556349 chr10:835070 NA 0.59 8.35 0.31 4.35e-16 Eosinophil percentage of granulocytes; BRCA cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Bladder cancer; BRCA cis rs6598955 0.671 rs7544 chr1:26607726 T/G cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg10556349 chr10:835070 NA 0.73 9.71 0.36 6.8e-21 Eosinophil percentage of granulocytes; BRCA cis rs9287719 0.967 rs12622765 chr2:10728331 T/C cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.03e-23 Prostate cancer; BRCA cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg11663144 chr21:46675770 NA -0.64 -15.38 -0.52 1.24e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg12165864 chr7:66369176 NA -0.46 -10.44 -0.38 1.13e-23 Corneal structure; BRCA cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs4727027 0.736 rs12704084 chr7:148915050 C/G cg23583168 chr7:148888333 NA -0.92 -24.01 -0.69 2.79e-91 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2625529 0.730 rs8182011 chr15:72389948 C/T cg16672083 chr15:72433130 SENP8 0.74 16.86 0.55 4.69e-53 Red blood cell count; BRCA cis rs7523050 0.643 rs34367763 chr1:109400805 C/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg03146154 chr1:46216737 IPP -0.47 -10.33 -0.38 3.19e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12711979 0.509 rs10191674 chr2:3827891 C/T cg17052675 chr2:3827356 NA -0.69 -23.74 -0.68 8.1e-90 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA cis rs6813479 0.524 rs2612113 chr4:137745583 C/G cg16185213 chr4:137733633 NA 0.34 8.19 0.31 1.37e-15 Longevity; BRCA cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7301826 0.651 rs7971046 chr12:131286807 G/A cg11011512 chr12:131303247 STX2 0.51 13.49 0.47 1.11e-36 Plasma plasminogen activator levels; BRCA cis rs7824557 0.606 rs1435277 chr8:11196970 C/T cg21775007 chr8:11205619 TDH 0.7 17.09 0.56 3.4e-54 Retinal vascular caliber; BRCA cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg13271783 chr10:134563150 INPP5A -0.51 -9.59 -0.35 1.99e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA trans rs3960554 1.000 rs2097947 chr7:75836382 A/T cg19862616 chr7:65841803 NCRNA00174 0.58 12.54 0.44 2.01e-32 Eotaxin levels; BRCA cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg08992911 chr2:238395768 MLPH 0.4 7.96 0.3 7.81e-15 Prostate cancer; BRCA cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg11663144 chr21:46675770 NA -0.53 -12.98 -0.46 2.31e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs61990749 0.597 rs2299930 chr14:78163722 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.58 -9.05 -0.34 1.65e-18 Fibroblast growth factor basic levels; BRCA cis rs7666738 0.830 rs28618180 chr4:98912184 A/C cg05340658 chr4:99064831 C4orf37 0.63 14.98 0.51 1.1e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.38 -7.87 -0.3 1.47e-14 Alzheimer's disease (late onset); BRCA cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg11247378 chr22:39784982 NA 0.61 14.49 0.5 2.5e-41 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs1003719 0.680 rs767998 chr21:38525652 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.43 -0.5 4.74e-41 Eye color traits; BRCA cis rs36051895 0.632 rs62541959 chr9:5175687 G/C cg02405213 chr9:5042618 JAK2 -0.48 -8.72 -0.33 2.39e-17 Pediatric autoimmune diseases; BRCA cis rs9463078 0.764 rs7754698 chr6:44782717 A/G cg25276700 chr6:44698697 NA -0.36 -8.3 -0.31 6.05e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs10992471 0.528 rs7022562 chr9:95216340 A/G cg14631576 chr9:95140430 CENPP -0.35 -8.7 -0.33 2.83e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs829883 0.622 rs4762498 chr12:98964737 A/G cg25150519 chr12:98850993 NA -0.48 -8.65 -0.32 4.25e-17 Colorectal adenoma (advanced); BRCA cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06022373 chr22:39101656 GTPBP1 0.67 16.95 0.56 1.69e-53 Menopause (age at onset); BRCA trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg23533926 chr12:111358616 MYL2 -0.43 -8.89 -0.33 6.43e-18 Extrinsic epigenetic age acceleration; BRCA cis rs2115536 0.704 rs2163005 chr15:80194480 A/G cg00225070 chr15:80189496 MTHFS 0.45 10.31 0.38 3.81e-23 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs17270561 0.609 rs1165155 chr6:25795577 A/T cg16482183 chr6:26056742 HIST1H1C 0.41 8.78 0.33 1.49e-17 Iron status biomarkers; BRCA cis rs12413816 0.824 rs1571008 chr10:13760776 T/C cg16485048 chr10:13749193 FRMD4A 0.58 14.08 0.49 1.96e-39 Red cell distribution width; BRCA cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.6 -0.32 6.2e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg08807101 chr21:30365312 RNF160 -0.57 -13.96 -0.48 7.55e-39 Dental caries; BRCA cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg24250549 chr1:154909240 PMVK 0.69 18.17 0.58 8.55e-60 Prostate cancer; BRCA cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.45 -0.47 1.72e-36 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg09877947 chr5:131593287 PDLIM4 0.41 9.69 0.36 8.24e-21 Acylcarnitine levels; BRCA cis rs4642101 0.640 rs12629398 chr3:12826799 A/G cg24848339 chr3:12840334 CAND2 0.47 12.77 0.45 2e-33 QRS complex (12-leadsum); BRCA cis rs829883 0.763 rs249843 chr12:98870987 G/A cg25150519 chr12:98850993 NA 0.67 16.5 0.55 3.36e-51 Colorectal adenoma (advanced); BRCA cis rs6964587 0.967 rs7786031 chr7:91649001 T/G cg17063962 chr7:91808500 NA 0.53 12.48 0.44 3.69e-32 Breast cancer; BRCA cis rs4319547 0.774 rs7959238 chr12:123131498 A/T cg05707623 chr12:122985044 ZCCHC8 -0.43 -9.02 -0.34 2.23e-18 Body mass index; BRCA cis rs1580019 0.921 rs1580023 chr7:32497881 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.38 8.41 0.32 2.58e-16 Cognitive ability; BRCA trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg03929089 chr4:120376271 NA 0.61 10.56 0.39 3.97e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.93 0.33 4.45e-18 Tonsillectomy; BRCA cis rs9814567 1.000 rs9819532 chr3:134288644 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.91 -0.33 5.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg16586182 chr3:47516702 SCAP 0.55 12.2 0.43 6.14e-31 Colorectal cancer; BRCA cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.08 16.37 0.54 1.44e-50 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7523273 0.606 rs2281289 chr1:207978916 C/T cg22525895 chr1:207977042 MIR29B2 -0.5 -12.84 -0.45 1.02e-33 Schizophrenia; BRCA cis rs2243480 0.901 rs2456483 chr7:65461575 T/C cg18252515 chr7:66147081 NA -0.86 -12.34 -0.44 1.53e-31 Diabetic kidney disease; BRCA cis rs7582180 0.614 rs4851309 chr2:100975390 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.85 -0.3 1.77e-14 Intelligence (multi-trait analysis); BRCA cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg11663144 chr21:46675770 NA -0.49 -10.15 -0.37 1.55e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4713118 0.662 rs9380045 chr6:28025279 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs26949 0.526 rs3899221 chr5:60036377 A/G cg02684056 chr5:59996105 DEPDC1B -0.34 -7.89 -0.3 1.32e-14 Intelligence (multi-trait analysis); BRCA trans rs2262909 0.962 rs12610034 chr19:22314528 G/A cg17074339 chr11:11642133 GALNTL4 0.45 8.88 0.33 6.73e-18 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs11711311 0.955 rs10934247 chr3:113534941 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.35 9.03 0.34 1.98e-18 IgG glycosylation; BRCA cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg08999081 chr20:33150536 PIGU 0.44 12.36 0.44 1.32e-31 Glomerular filtration rate (creatinine); BRCA cis rs17125944 0.505 rs75296244 chr14:53233218 G/A cg00686598 chr14:53173677 PSMC6 1.26 16.57 0.55 1.38e-51 Alzheimer's disease (late onset); BRCA cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg21132104 chr15:45694354 SPATA5L1 0.7 15.4 0.52 1.01e-45 Homoarginine levels; BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg21782813 chr7:2030301 MAD1L1 0.4 10.7 0.39 1.08e-24 Bipolar disorder and schizophrenia; BRCA cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg04455712 chr21:45112962 RRP1B 0.41 10.92 0.4 1.4e-25 Mean corpuscular volume; BRCA cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.39 0.44 9.53e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.73 14.97 0.51 1.26e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg01579765 chr21:45077557 HSF2BP -0.42 -11.68 -0.42 1.03e-28 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg08888203 chr3:10149979 C3orf24 0.66 14.08 0.49 2.03e-39 Alzheimer's disease; BRCA cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.21 -0.54 9.23e-50 Heart rate; BRCA cis rs4363385 0.818 rs11205174 chr1:153001230 C/T cg24667326 chr1:152973720 SPRR3 0.32 8.71 0.33 2.67e-17 Inflammatory skin disease; BRCA cis rs3106136 0.527 rs2664872 chr4:95146952 G/A cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.07 -0.37 2.97e-22 Capecitabine sensitivity; BRCA trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg03929089 chr4:120376271 NA 0.56 9.08 0.34 1.31e-18 Axial length; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg22907277 chr7:1156413 C7orf50 0.59 9.18 0.34 5.82e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2834485 1.000 rs5010906 chr21:35818590 G/C cg07474852 chr4:123073612 NA 0.48 10.27 0.38 5.44e-23 Cancer; BRCA cis rs826838 0.967 rs826856 chr12:39115434 G/A cg13010199 chr12:38710504 ALG10B -0.43 -10.01 -0.37 5.32e-22 Heart rate; BRCA cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg17420585 chr12:42539391 GXYLT1 -0.47 -9.97 -0.37 7.33e-22 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs1325195 1.000 rs1325195 chr1:179071756 G/A cg11624085 chr17:8464688 MYH10 -0.27 -8.52 -0.32 1.16e-16 IgE grass sensitization; BRCA trans rs3733585 0.781 rs13103879 chr4:9972879 T/C cg26043149 chr18:55253948 FECH -0.41 -9.16 -0.34 7.11e-19 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4965272 0.953 rs12441162 chr15:100592818 C/T cg27344315 chr15:100560801 ADAMTS17 -0.43 -8.36 -0.31 4.03e-16 Gastroesophageal reflux disease; BRCA cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg00071950 chr4:10020882 SLC2A9 0.54 13.4 0.47 3.05e-36 Bone mineral density; BRCA cis rs11608355 0.545 rs2302708 chr12:109893726 A/C cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg09184832 chr6:79620586 NA -0.55 -12.1 -0.43 1.76e-30 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg20476274 chr7:133979776 SLC35B4 0.66 19.46 0.61 1.39e-66 Mean platelet volume; BRCA cis rs9287719 0.901 rs55861579 chr2:10763340 T/A cg00105475 chr2:10696890 NA 0.44 10.1 0.37 2.43e-22 Prostate cancer; BRCA cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs854572 0.600 rs705382 chr7:94955221 C/G cg19678392 chr7:94953810 PON1 -0.44 -10.28 -0.38 4.72e-23 Paraoxonase activity; BRCA cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.07e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs4650994 1.000 rs10913570 chr1:178523126 A/C cg05059571 chr16:84539110 KIAA1609 -0.42 -9.51 -0.35 3.7e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs2204008 0.776 rs3861074 chr12:38483021 C/T cg26384229 chr12:38710491 ALG10B 0.74 15.92 0.53 2.63e-48 Bladder cancer; BRCA cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.12e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg26647111 chr11:31128758 NA 0.4 8.73 0.33 2.26e-17 Red blood cell count; BRCA cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg00684032 chr4:1343700 KIAA1530 -0.35 -8.92 -0.33 4.97e-18 Obesity-related traits; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.61 -13.1 -0.46 6.7e-35 Lymphocyte counts; BRCA cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg26384229 chr12:38710491 ALG10B 0.75 17.0 0.56 9.05e-54 Bladder cancer; BRCA cis rs9790314 1.000 rs464766 chr3:161087592 C/G cg03342759 chr3:160939853 NMD3 -0.54 -11.63 -0.42 1.75e-28 Morning vs. evening chronotype; BRCA trans rs61931739 0.635 rs1601627 chr12:33962420 G/A cg26384229 chr12:38710491 ALG10B 0.39 8.87 0.33 7e-18 Morning vs. evening chronotype; BRCA cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg24596788 chr1:163392923 NA 0.36 9.67 0.36 9.65e-21 Motion sickness; BRCA cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.03 0.49 3.57e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7737355 0.947 rs3776027 chr5:130802970 T/C cg06307176 chr5:131281290 NA -0.52 -10.51 -0.38 6e-24 Life satisfaction; BRCA cis rs2832191 0.692 rs2245734 chr21:30359965 C/T cg24692254 chr21:30365293 RNF160 0.79 21.84 0.65 2.02e-79 Dental caries; BRCA cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg07606381 chr6:8435919 SLC35B3 -0.63 -13.9 -0.48 1.5e-38 Motion sickness; BRCA cis rs922182 0.617 rs2899697 chr15:64240436 T/C cg24729988 chr15:64271149 DAPK2 0.49 10.73 0.39 8.62e-25 Blood protein levels; BRCA cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg20476274 chr7:133979776 SLC35B4 0.65 19.39 0.61 3.04e-66 Mean platelet volume; BRCA cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg08847533 chr14:75593920 NEK9 -0.86 -21.61 -0.65 3.52e-78 Height; BRCA cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg23583168 chr7:148888333 NA -0.85 -19.4 -0.61 2.91e-66 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9325144 0.600 rs1825807 chr12:38737007 T/C cg26384229 chr12:38710491 ALG10B 0.5 12.47 0.44 4.1e-32 Morning vs. evening chronotype; BRCA cis rs9818758 0.556 rs9813813 chr3:49207093 T/A cg01304814 chr3:48885189 PRKAR2A 0.71 8.01 0.3 5.28e-15 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs8022179 0.580 rs58153827 chr14:103844630 G/A cg12935359 chr14:103987150 CKB 0.52 9.98 0.37 6.95e-22 Monocyte count; BRCA cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.59 -0.35 2.01e-20 Developmental language disorder (linguistic errors); BRCA cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg04546413 chr19:29218101 NA 0.66 13.28 0.46 1.08e-35 Methadone dose in opioid dependence; BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg10950524 chr7:2139216 MAD1L1 0.27 7.84 0.3 1.88e-14 Schizophrenia; BRCA cis rs7639513 0.767 rs13060705 chr3:12710016 C/A cg23032965 chr3:12705835 RAF1 0.69 15.37 0.52 1.28e-45 Itch intensity from mosquito bite; BRCA cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg12386194 chr3:101231763 SENP7 0.6 12.21 0.43 5.79e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs7927771 0.524 rs11039415 chr11:47845814 A/G cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Subjective well-being; BRCA cis rs9858542 1.000 rs11709525 chr3:49690496 C/T cg03060546 chr3:49711283 APEH -0.61 -12.33 -0.44 1.69e-31 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4409675 0.576 rs6679432 chr1:28227665 T/C cg23691781 chr1:28212827 C1orf38 0.32 10.66 0.39 1.5e-24 Corneal astigmatism; BRCA cis rs4363385 0.818 rs10788856 chr1:153011517 G/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs708547 0.647 rs1403233 chr4:57885053 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.37 -9.42 -0.35 7.95e-20 Response to bleomycin (chromatid breaks); BRCA cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.79 0.36 3.52e-21 Bipolar disorder; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1635 0.655 rs16893973 chr6:28302113 C/T cg15743358 chr6:28303923 ZNF323 -0.75 -8.7 -0.33 2.85e-17 Schizophrenia; BRCA cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg20307385 chr11:47447363 PSMC3 -0.43 -9.03 -0.34 1.96e-18 Subjective well-being; BRCA cis rs9394841 0.667 rs1891453 chr6:41765265 T/C cg08135965 chr6:41755394 TOMM6 0.5 8.13 0.31 2.18e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg05234568 chr11:5960015 NA -0.47 -10.75 -0.39 6.82e-25 DNA methylation (variation); BRCA cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg11584989 chr19:19387371 SF4 -0.62 -13.16 -0.46 3.66e-35 Bipolar disorder; BRCA cis rs13046373 0.535 rs1911571 chr21:32031538 A/C cg16812893 chr21:31813075 KRTAP15-1 0.37 9.3 0.35 2.17e-19 HDL cholesterol; BRCA cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.37 0.35 1.18e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9790314 0.723 rs1026572 chr3:160887654 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -8.02 -0.3 4.95e-15 Morning vs. evening chronotype; BRCA cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg16049864 chr8:95962084 TP53INP1 -0.44 -10.78 -0.39 5.31e-25 Type 2 diabetes; BRCA cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 7.95 0.3 8.77e-15 Personality dimensions; BRCA cis rs2251381 0.750 rs2251087 chr21:30527999 C/T cg08807101 chr21:30365312 RNF160 0.62 13.46 0.47 1.59e-36 Selective IgA deficiency; BRCA cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs9287719 0.674 rs10929690 chr2:10805974 T/C cg02196655 chr2:10830764 NOL10 0.29 7.81 0.3 2.27e-14 Prostate cancer; BRCA cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs1003719 0.715 rs2835675 chr21:38582815 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.45 -0.5 3.7e-41 Eye color traits; BRCA cis rs739401 0.611 rs417957 chr11:3046231 A/G cg05729581 chr11:3078854 CARS -0.36 -8.84 -0.33 9.48e-18 Longevity; BRCA cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg05234568 chr11:5960015 NA 0.53 12.04 0.43 3.16e-30 DNA methylation (variation); BRCA cis rs9341808 0.791 rs1324122 chr6:80946061 G/A cg08355045 chr6:80787529 NA 0.39 9.95 0.37 8.77e-22 Sitting height ratio; BRCA cis rs7103648 0.669 rs7114011 chr11:47811309 A/C cg03711944 chr11:47377212 SPI1 -0.38 -9.11 -0.34 1.02e-18 Diastolic blood pressure;Systolic blood pressure; BRCA trans rs208520 1.000 rs208527 chr6:66957209 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -14.55 -0.5 1.17e-41 Exhaled nitric oxide output; BRCA cis rs13046373 0.535 rs7276743 chr21:31984545 C/T cg06468780 chr21:31798236 KRTAP13-3 0.34 8.34 0.31 4.45e-16 HDL cholesterol; BRCA cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.53 8.89 0.33 6.37e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4363385 0.693 rs310102 chr1:153042423 T/C cg25856811 chr1:152973957 SPRR3 -0.31 -8.01 -0.3 5.53e-15 Inflammatory skin disease; BRCA cis rs17376456 0.877 rs28539612 chr5:93499099 C/T cg25358565 chr5:93447407 FAM172A 1.24 18.91 0.6 1.1e-63 Diabetic retinopathy; BRCA cis rs4363385 0.693 rs440598 chr1:153044733 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.04 -0.3 4.26e-15 Inflammatory skin disease; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.58 -11.04 -0.4 4.82e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -12.87 -0.45 7.39e-34 Monocyte percentage of white cells; BRCA cis rs4566357 0.521 rs78411533 chr2:227910807 G/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.12 -0.31 2.34e-15 Coronary artery disease; BRCA cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg11266682 chr4:10021025 SLC2A9 0.45 11.9 0.43 1.26e-29 Bone mineral density; BRCA cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg27170947 chr2:26402098 FAM59B -0.99 -17.06 -0.56 4.44e-54 Gut microbiome composition (summer); BRCA cis rs477692 0.935 rs554458 chr10:131427372 A/G cg05714579 chr10:131428358 MGMT 0.59 14.65 0.5 3.99e-42 Response to temozolomide; BRCA cis rs2625529 0.824 rs10518979 chr15:72268986 A/G cg16672083 chr15:72433130 SENP8 -0.86 -17.76 -0.57 1.11e-57 Red blood cell count; BRCA cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14442939 chr10:27389572 ANKRD26 0.7 11.0 0.4 6.54e-26 Breast cancer; BRCA cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.54 -9.75 -0.36 4.93e-21 Response to bleomycin (chromatid breaks); BRCA cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.72 0.39 9.35e-25 Cognitive ability; BRCA cis rs919433 0.680 rs2565161 chr2:198285554 C/G cg00792783 chr2:198669748 PLCL1 0.38 8.39 0.32 3.12e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg12193833 chr17:30244370 NA -0.55 -8.62 -0.32 5.36e-17 Hip circumference adjusted for BMI; BRCA cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg11247378 chr22:39784982 NA -0.64 -15.78 -0.53 1.31e-47 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs1371614 0.635 rs10196691 chr2:27141359 T/A cg12368169 chr2:27073192 DPYSL5 -0.29 -8.54 -0.32 9.6e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs12711979 0.765 rs6705742 chr2:3820672 C/T cg17052675 chr2:3827356 NA -0.48 -14.21 -0.49 5.12e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg15128208 chr22:42549153 NA 0.32 8.25 0.31 8.99e-16 Cognitive function; BRCA cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -10.24 -0.38 6.57e-23 Mean corpuscular volume; BRCA cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg13319975 chr6:146136371 FBXO30 0.35 8.07 0.3 3.44e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg24642439 chr20:33292090 TP53INP2 0.43 9.19 0.34 5.32e-19 Height; BRCA cis rs4268898 0.931 rs2111882 chr2:24434424 A/G cg06627628 chr2:24431161 ITSN2 0.55 11.2 0.4 1.07e-26 Asthma; BRCA cis rs7945705 0.875 rs10769947 chr11:8758114 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.48 10.23 0.38 7.6e-23 Hemoglobin concentration; BRCA trans rs8002861 0.869 rs7989857 chr13:44464090 C/T cg17145862 chr1:211918768 LPGAT1 0.73 19.6 0.61 2.43e-67 Leprosy; BRCA cis rs889312 0.500 rs865570 chr5:56161975 C/T cg24531977 chr5:56204891 C5orf35 -0.4 -8.07 -0.3 3.39e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg11833968 chr6:79620685 NA -0.45 -9.84 -0.36 2.37e-21 Intelligence (multi-trait analysis); BRCA cis rs7927771 1.000 rs10838748 chr11:47716381 T/G cg18512352 chr11:47633146 NA -0.34 -8.31 -0.31 5.91e-16 Subjective well-being; BRCA cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg24250549 chr1:154909240 PMVK 0.67 17.32 0.57 2.16e-55 Prostate cancer; BRCA cis rs910873 0.505 rs7261964 chr20:33205011 C/T cg16810054 chr20:33298113 TP53INP2 -0.47 -10.01 -0.37 5.2e-22 Melanoma; BRCA cis rs9650657 0.547 rs11250099 chr8:10818657 C/T cg21775007 chr8:11205619 TDH 0.42 8.5 0.32 1.36e-16 Neuroticism; BRCA cis rs9434723 0.920 rs2239560 chr1:9304731 C/T cg04199779 chr1:9294473 H6PD 0.48 8.53 0.32 1.02e-16 Height; BRCA cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg02733842 chr7:1102375 C7orf50 -0.64 -11.68 -0.42 1.09e-28 Bronchopulmonary dysplasia; BRCA cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg23711669 chr6:146136114 FBXO30 0.73 17.53 0.57 1.75e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg20701182 chr2:24300061 SF3B14 0.55 8.51 0.32 1.21e-16 Lymphocyte counts; BRCA cis rs2243480 1.000 rs34703416 chr7:65300642 A/G cg18252515 chr7:66147081 NA -0.81 -11.24 -0.41 6.88e-27 Diabetic kidney disease; BRCA cis rs965469 1.000 rs6037556 chr20:3317890 G/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.56 -0.39 3.9e-24 IFN-related cytopenia; BRCA cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.93 -0.3 9.7e-15 Bipolar disorder; BRCA cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg15145296 chr3:125709740 NA -0.55 -8.7 -0.33 2.7e-17 Blood pressure (smoking interaction); BRCA cis rs7474896 0.609 rs1830612 chr10:37999883 A/G cg25427524 chr10:38739819 LOC399744 -0.53 -9.27 -0.34 2.88e-19 Obesity (extreme); BRCA cis rs2882667 0.858 rs13170388 chr5:138436865 A/G cg04439458 chr5:138467593 SIL1 -0.41 -10.37 -0.38 2.07e-23 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4891159 0.527 rs689642 chr18:74119120 A/C cg24786174 chr18:74118243 ZNF516 0.84 25.82 0.71 3.3e-101 Longevity; BRCA cis rs4478137 0.931 rs11100488 chr4:164237660 C/A cg06758707 chr4:164254230 NPY1R 0.59 12.99 0.46 2.04e-34 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg02079420 chr8:82753780 SNX16 0.31 8.43 0.32 2.27e-16 Diastolic blood pressure; BRCA trans rs7618501 0.521 rs11130222 chr3:49901060 A/T cg21659725 chr3:3221576 CRBN 0.38 8.84 0.33 8.91e-18 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg08470875 chr2:26401718 FAM59B -0.7 -11.27 -0.41 5.41e-27 Gut microbiome composition (summer); BRCA cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg01483505 chr11:975446 AP2A2 0.35 9.37 0.35 1.27e-19 Alzheimer's disease (late onset); BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 2e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2070488 0.965 rs13093640 chr3:38487176 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 20.34 0.63 2.67e-71 Electrocardiographic conduction measures; BRCA cis rs9341808 0.718 rs7740627 chr6:80916347 A/G cg08355045 chr6:80787529 NA 0.39 10.0 0.37 5.65e-22 Sitting height ratio; BRCA cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg03709012 chr19:19516395 GATAD2A 0.73 16.16 0.54 1.74e-49 Tonsillectomy; BRCA cis rs9875589 0.509 rs4685051 chr3:13981760 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.31 8.09 0.3 2.93e-15 Ovarian reserve; BRCA cis rs4746818 0.711 rs4745976 chr10:70845181 A/G cg11621586 chr10:70884670 VPS26A 0.45 8.12 0.31 2.41e-15 Left atrial antero-posterior diameter; BRCA cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg00684032 chr4:1343700 KIAA1530 0.53 12.47 0.44 4.28e-32 Obesity-related traits; BRCA cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05903289 chr2:130345205 NA -0.33 -8.3 -0.31 6.35e-16 Response to cytidine analogues (gemcitabine); BRCA cis rs7577696 0.512 rs212691 chr2:32438075 G/A cg02381751 chr2:32503542 YIPF4 0.46 8.44 0.32 2.12e-16 Inflammatory biomarkers; BRCA cis rs1568889 1.000 rs16917735 chr11:28119980 A/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.58 -12.5 -0.44 3.21e-32 Bipolar disorder; BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.08 -0.3 3.16e-15 Total body bone mineral density; BRCA cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg26384229 chr12:38710491 ALG10B 0.85 22.84 0.67 7.26e-85 Heart rate; BRCA cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.08 0.3 3.34e-15 Aortic root size; BRCA cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02018176 chr4:1364513 KIAA1530 0.4 7.96 0.3 8.12e-15 Longevity; BRCA cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.1 15.83 0.53 7.44e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg12292205 chr6:26970375 C6orf41 0.73 16.65 0.55 5.71e-52 Autism spectrum disorder or schizophrenia; BRCA trans rs11098499 0.909 rs9994810 chr4:120381590 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.3e-14 Corneal astigmatism; BRCA cis rs6484504 0.516 rs1999250 chr11:31287455 C/T cg06552810 chr11:31128660 NA -0.4 -8.88 -0.33 6.88e-18 Red blood cell count; BRCA cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg08999081 chr20:33150536 PIGU 0.37 9.59 0.35 2e-20 Coronary artery disease; BRCA trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.68 17.54 0.57 1.64e-56 Age-related macular degeneration (geographic atrophy); BRCA cis rs6977660 0.714 rs17141945 chr7:19805056 T/A cg05791153 chr7:19748676 TWISTNB 0.59 10.83 0.39 3.39e-25 Thyroid stimulating hormone; BRCA cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs9287719 0.967 rs2110776 chr2:10748810 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg06970220 chr1:156163860 SLC25A44 0.39 7.88 0.3 1.39e-14 Testicular germ cell tumor; BRCA cis rs2904967 1.000 rs630055 chr11:65087533 G/T cg09225861 chr11:65069680 NA -0.38 -7.95 -0.3 8.73e-15 Mean corpuscular volume; BRCA cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg22903657 chr4:1355424 KIAA1530 -0.36 -8.11 -0.31 2.6e-15 Obesity-related traits; BRCA cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg09035930 chr12:129282057 SLC15A4 -0.56 -16.6 -0.55 9.65e-52 Systemic lupus erythematosus; BRCA trans rs11098499 0.580 rs12509234 chr4:120319434 T/C cg25517755 chr10:38738941 LOC399744 -0.37 -7.87 -0.3 1.53e-14 Corneal astigmatism; BRCA cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg02574844 chr11:5959923 NA -0.4 -8.33 -0.31 4.96e-16 DNA methylation (variation); BRCA cis rs7267979 1.000 rs2258066 chr20:25271326 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs35146811 0.586 rs6964754 chr7:99589404 G/A cg13334819 chr7:99746414 C7orf59 -0.35 -7.93 -0.3 9.57e-15 Coronary artery disease; BRCA cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.6e-113 Chronic sinus infection; BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 13.39 0.47 3.29e-36 Lymphocyte counts; BRCA trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg23533926 chr12:111358616 MYL2 0.39 8.26 0.31 8.23e-16 Extrinsic epigenetic age acceleration; BRCA cis rs7819412 0.595 rs10503416 chr8:10987553 C/T cg21775007 chr8:11205619 TDH 0.47 9.93 0.37 1.02e-21 Triglycerides; BRCA cis rs68170813 0.559 rs997311 chr7:106953033 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.53 -0.32 1.02e-16 Coronary artery disease; BRCA cis rs2204008 0.744 rs66474616 chr12:38461564 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.41 0.38 1.57e-23 Bladder cancer; BRCA cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs3849570 0.961 rs3849571 chr3:81777716 A/C cg07356753 chr3:81810745 GBE1 -0.47 -11.41 -0.41 1.35e-27 Waist circumference;Body mass index; BRCA cis rs6691722 0.506 rs1016209 chr1:24745615 A/G cg18323236 chr1:24743029 NIPAL3 -0.36 -10.17 -0.37 1.27e-22 Response to interferon beta in multiple sclerosis; BRCA cis rs2249625 0.523 rs2463707 chr6:72861732 G/A cg18830697 chr6:72922368 RIMS1 -0.51 -11.49 -0.41 6.66e-28 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg01256987 chr12:42539512 GXYLT1 -0.57 -11.64 -0.42 1.49e-28 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12348691 0.503 rs7048394 chr9:100605433 T/C cg13688889 chr9:100608707 NA -0.49 -10.0 -0.37 5.81e-22 Alopecia areata; BRCA cis rs9325144 0.560 rs2387923 chr12:38662677 G/A cg26384229 chr12:38710491 ALG10B -0.5 -13.14 -0.46 4.29e-35 Morning vs. evening chronotype; BRCA cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg11833968 chr6:79620685 NA -0.43 -9.4 -0.35 9.24e-20 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.63 -12.17 -0.43 8.36e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1691799 0.899 rs1168320 chr12:66744849 C/T cg16791601 chr12:66731901 HELB -0.69 -19.67 -0.61 1.03e-67 White blood cell count (basophil); BRCA cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg16339924 chr4:17578868 LAP3 0.67 16.95 0.56 1.68e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg13852791 chr20:30311386 BCL2L1 0.86 16.75 0.55 1.82e-52 Mean corpuscular hemoglobin; BRCA cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg11608241 chr8:8085544 FLJ10661 -0.28 -8.03 -0.3 4.69e-15 Mood instability; BRCA cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg11812906 chr14:75593930 NEK9 0.57 12.37 0.44 1.19e-31 Coronary artery disease; BRCA cis rs4742903 0.527 rs10820607 chr9:106888750 A/C cg14250997 chr9:106856677 SMC2 0.29 8.53 0.32 1.05e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.54 -0.44 2.05e-32 Alzheimer's disease; BRCA cis rs977987 0.806 rs4888383 chr16:75386349 C/T cg03315344 chr16:75512273 CHST6 0.5 11.79 0.42 3.75e-29 Dupuytren's disease; BRCA trans rs877282 0.853 rs11595510 chr10:756757 C/G cg22713356 chr15:30763199 NA 1.26 22.09 0.66 8.41e-81 Uric acid levels; BRCA cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg04450456 chr4:17643702 FAM184B 0.41 12.15 0.43 1.06e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23248424 chr5:179741104 GFPT2 -0.64 -13.5 -0.47 9.64e-37 Height; BRCA cis rs701145 0.938 rs2596630 chr3:153992586 A/G cg17054900 chr3:154042577 DHX36 0.68 11.79 0.42 3.71e-29 Coronary artery disease; BRCA cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.26 0.59 2.84e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.85 0.39 2.66e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7131987 0.868 rs737160 chr12:29429012 T/C cg09582351 chr12:29534625 ERGIC2 -0.42 -10.05 -0.37 3.53e-22 QT interval; BRCA cis rs12760731 0.565 rs11585236 chr1:178108441 G/A cg00404053 chr1:178313656 RASAL2 0.65 8.14 0.31 2.04e-15 Obesity-related traits; BRCA cis rs9914988 0.943 rs2043032 chr17:27136692 A/G cg20469991 chr17:27169893 C17orf63 -0.48 -8.95 -0.33 3.81e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs4363385 0.818 rs10788852 chr1:153000491 C/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.41 -0.32 2.58e-16 Inflammatory skin disease; BRCA cis rs2742234 0.590 rs2742237 chr10:43621323 C/G cg15436174 chr10:43711423 RASGEF1A -0.56 -11.16 -0.4 1.46e-26 Hirschsprung disease; BRCA cis rs2505998 1.000 rs2505998 chr10:43570925 A/G cg15436174 chr10:43711423 RASGEF1A -0.44 -8.62 -0.32 5.06e-17 Hirschsprung disease; BRCA cis rs10267417 0.603 rs10263094 chr7:19872801 C/T cg05791153 chr7:19748676 TWISTNB 0.49 9.27 0.34 2.88e-19 Night sleep phenotypes; BRCA cis rs12541635 0.677 rs6469026 chr8:107006356 T/C cg10147462 chr8:107024639 NA 0.4 10.53 0.38 5.13e-24 Age of smoking initiation; BRCA cis rs1018836 0.923 rs13267989 chr8:91581648 C/T cg16814680 chr8:91681699 NA -0.58 -12.32 -0.44 2e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs365132 0.934 rs149307 chr5:176471591 C/T cg16309518 chr5:176445507 NA -0.52 -13.02 -0.46 1.59e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs416603 0.967 rs7191538 chr16:11363389 C/G cg00044050 chr16:11439710 C16orf75 -0.43 -10.09 -0.37 2.48e-22 Type 1 diabetes; BRCA cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg00290607 chr11:67383545 NA -0.54 -12.59 -0.45 1.28e-32 Mean corpuscular volume; BRCA cis rs875971 0.964 rs778723 chr7:65829497 T/C cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.85e-67 Aortic root size; BRCA cis rs62229266 0.740 rs2835233 chr21:37393582 A/G cg12218747 chr21:37451666 NA -0.34 -8.08 -0.3 3.16e-15 Mitral valve prolapse; BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg26314531 chr2:26401878 FAM59B -0.78 -12.5 -0.44 3.19e-32 Gut microbiome composition (summer); BRCA cis rs9788721 0.802 rs56219465 chr15:78742579 A/G cg18825076 chr15:78729989 IREB2 -0.39 -8.23 -0.31 1.08e-15 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs7098414 0.511 rs10749592 chr10:82150891 C/T cg00277334 chr10:82204260 NA -0.5 -10.73 -0.39 7.97e-25 Post bronchodilator FEV1; BRCA cis rs2816062 0.786 rs2745316 chr1:18896830 G/A cg18795169 chr1:18902165 NA -0.97 -29.22 -0.76 7.6e-120 Urate levels in lean individuals; BRCA cis rs3857536 0.706 rs1418854 chr6:66893284 C/T cg07460842 chr6:66804631 NA -0.46 -8.83 -0.33 1.02e-17 Blood trace element (Cu levels); BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg12419862 chr22:24373484 LOC391322 -0.66 -14.99 -0.51 9.83e-44 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg06064525 chr11:970664 AP2A2 -0.49 -16.41 -0.54 9.05e-51 Alzheimer's disease (late onset); BRCA cis rs593982 1.000 rs1941746 chr11:65502413 A/G cg08755490 chr11:65554678 OVOL1 1.27 29.33 0.76 1.95e-120 Atopic dermatitis; BRCA cis rs9649465 0.967 rs6950373 chr7:123361773 C/T cg04330084 chr7:123175371 IQUB -0.33 -9.0 -0.34 2.51e-18 Migraine; BRCA cis rs6088580 0.524 rs6088552 chr20:33226491 A/G cg08999081 chr20:33150536 PIGU -0.34 -8.77 -0.33 1.56e-17 Glomerular filtration rate (creatinine); BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.38 8.24 0.31 9.59e-16 Tonsillectomy; BRCA cis rs68170813 0.559 rs74745121 chr7:106958037 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.72 -0.33 2.46e-17 Coronary artery disease; BRCA cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg11502198 chr6:26597334 ABT1 0.43 8.13 0.31 2.18e-15 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.644 rs10009566 chr4:120558608 A/G cg25214090 chr10:38739885 LOC399744 0.44 10.1 0.37 2.4e-22 Corneal astigmatism; BRCA trans rs4332037 0.552 rs11773627 chr7:2002733 A/G cg25206134 chr2:45395956 NA 0.49 8.54 0.32 9.79e-17 Bipolar disorder; BRCA cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg20891283 chr12:69753455 YEATS4 0.83 28.18 0.74 3.43e-114 Cerebrospinal fluid biomarker levels; BRCA cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg11266682 chr4:10021025 SLC2A9 0.45 11.99 0.43 4.9e-30 Bone mineral density; BRCA cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.04 -0.58 4.15e-59 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs10014986 chr4:99000687 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05901451 chr6:126070800 HEY2 0.44 10.98 0.4 8.35e-26 Endometrial cancer; BRCA trans rs9784649 0.760 rs17343923 chr5:25052414 G/A cg11038491 chr20:34638489 LOC647979 -0.5 -9.13 -0.34 8.87e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11674184 0.632 rs17529680 chr2:11727087 A/C cg07314298 chr2:11723111 GREB1 0.7 14.37 0.49 8.87e-41 Endometriosis; BRCA trans rs3780486 0.629 rs10971439 chr9:33180813 C/T cg20290983 chr6:43655470 MRPS18A -0.85 -14.42 -0.5 5.23e-41 IgG glycosylation; BRCA cis rs10791097 0.765 rs7943757 chr11:130716157 C/T cg12179176 chr11:130786555 SNX19 0.5 10.78 0.39 5.21e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.21 0.37 8.65e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3617 0.573 rs3821873 chr3:52913006 C/T cg11645453 chr3:52864694 ITIH4 -0.37 -9.69 -0.36 8.24e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs6460942 1.000 rs79964328 chr7:12319392 A/C cg06484146 chr7:12443880 VWDE -0.62 -8.57 -0.32 7.55e-17 Coronary artery disease; BRCA cis rs10752881 1.000 rs10797802 chr1:182973158 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.64 -16.76 -0.55 1.55e-52 Colorectal cancer; BRCA cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg22105103 chr4:187893119 NA 0.37 11.92 0.43 1.05e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg13047869 chr3:10149882 C3orf24 0.53 11.33 0.41 2.9e-27 Alzheimer's disease; BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg08470875 chr2:26401718 FAM59B -0.58 -9.2 -0.34 4.82e-19 Gut microbiome composition (summer); BRCA cis rs2304069 0.954 rs4705408 chr5:149412545 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.84 -17.11 -0.56 2.54e-54 HIV-1 control; BRCA cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24531977 chr5:56204891 C5orf35 -0.87 -18.04 -0.58 4.2e-59 Initial pursuit acceleration; BRCA trans rs4650994 0.544 rs2761469 chr1:178590638 A/C cg05059571 chr16:84539110 KIAA1609 0.52 11.63 0.42 1.78e-28 HDL cholesterol levels;HDL cholesterol; BRCA trans rs11098499 0.863 rs3775843 chr4:120427844 T/C cg25214090 chr10:38739885 LOC399744 0.55 12.18 0.43 7.52e-31 Corneal astigmatism; BRCA cis rs9287719 0.967 rs7570118 chr2:10718007 G/T cg00105475 chr2:10696890 NA 0.44 10.27 0.38 5.08e-23 Prostate cancer; BRCA cis rs1595825 0.838 rs60079260 chr2:198673636 G/A cg19156104 chr2:198669113 PLCL1 -0.48 -8.58 -0.32 7.39e-17 Ulcerative colitis; BRCA cis rs11098499 0.615 rs28551750 chr4:120264901 C/T cg09307838 chr4:120376055 NA 0.6 13.0 0.46 1.91e-34 Corneal astigmatism; BRCA trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -16.69 -0.55 3.62e-52 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.34 -10.7 -0.39 1.05e-24 Bipolar disorder; BRCA cis rs17818399 0.926 rs1824050 chr2:46839477 T/C cg02822958 chr2:46747628 ATP6V1E2 0.55 9.92 0.37 1.13e-21 Height; BRCA cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.3 7.85 0.3 1.73e-14 Monocyte percentage of white cells; BRCA cis rs713587 0.563 rs10865315 chr2:25100738 C/A cg04586622 chr2:25135609 ADCY3 0.44 11.23 0.41 8.19e-27 Body mass index in non-asthmatics; BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24531977 chr5:56204891 C5orf35 -0.86 -18.47 -0.59 2.37e-61 Initial pursuit acceleration; BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg08219700 chr8:58056026 NA 0.63 10.0 0.37 5.69e-22 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg16145915 chr7:1198662 ZFAND2A -0.47 -11.16 -0.4 1.51e-26 Longevity;Endometriosis; BRCA cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg26597838 chr10:835615 NA 0.64 11.12 0.4 2.17e-26 Eosinophil percentage of granulocytes; BRCA cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg06640241 chr16:89574553 SPG7 -0.58 -11.67 -0.42 1.11e-28 Multiple myeloma (IgH translocation); BRCA cis rs9325144 0.957 rs1995419 chr12:38950726 C/G cg26384229 chr12:38710491 ALG10B 0.45 8.97 0.33 3.2e-18 Morning vs. evening chronotype; BRCA cis rs1153858 1.000 rs4775907 chr15:45638647 G/A cg21132104 chr15:45694354 SPATA5L1 0.7 15.45 0.52 5.52e-46 Homoarginine levels; BRCA trans rs6076960 0.681 rs4487157 chr20:6249581 G/A cg21095983 chr6:86352623 SYNCRIP 0.42 9.06 0.34 1.53e-18 Smooth-surface caries; BRCA trans rs1459104 0.571 rs10459012 chr11:55091574 C/A cg03929089 chr4:120376271 NA 0.54 9.63 0.36 1.38e-20 Body mass index; BRCA cis rs6460942 1.000 rs2053378 chr7:12405564 C/G cg06484146 chr7:12443880 VWDE -0.7 -9.7 -0.36 7.38e-21 Coronary artery disease; BRCA cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg15556689 chr8:8085844 FLJ10661 0.42 11.72 0.42 6.93e-29 Mood instability; BRCA cis rs1005277 0.579 rs2474595 chr10:38426782 C/G cg25427524 chr10:38739819 LOC399744 0.69 16.61 0.55 8.83e-52 Extrinsic epigenetic age acceleration; BRCA cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg05234568 chr11:5960015 NA -0.4 -8.33 -0.31 4.75e-16 DNA methylation (variation); BRCA cis rs897080 0.552 rs1085443 chr2:44635015 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.48 0.35 5.06e-20 Height; BRCA cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg17724175 chr1:150552817 MCL1 -0.3 -10.03 -0.37 4.42e-22 Blood protein levels; BRCA cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg01579765 chr21:45077557 HSF2BP -0.42 -11.32 -0.41 3.4e-27 Mean corpuscular volume; BRCA cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg22431228 chr1:16359049 CLCNKA -0.47 -9.7 -0.36 7.58e-21 Dilated cardiomyopathy; BRCA cis rs11146838 1 rs11146838 chr10:39149977 A/T cg25427524 chr10:38739819 LOC399744 -0.79 -20.45 -0.63 6.97e-72 Breast cancer; BRCA cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg00631329 chr6:26305371 NA -0.55 -15.65 -0.53 5.64e-47 Educational attainment; BRCA cis rs6964587 1.000 rs2285333 chr7:91667692 T/G cg17063962 chr7:91808500 NA 0.53 12.43 0.44 6.26e-32 Breast cancer; BRCA cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg12893428 chr3:195717962 SDHAP1 0.35 8.18 0.31 1.53e-15 Pancreatic cancer; BRCA cis rs4363385 0.747 rs6670614 chr1:152964338 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.93 -0.37 1.04e-21 Inflammatory skin disease; BRCA trans rs61931739 0.534 rs2220547 chr12:34106255 G/A cg13010199 chr12:38710504 ALG10B 0.47 9.0 0.34 2.52e-18 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg06784218 chr1:46089804 CCDC17 -0.44 -10.47 -0.38 8.95e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11229555 0.645 rs61889554 chr11:58424081 C/A cg15696309 chr11:58395628 NA -0.43 -8.95 -0.33 3.87e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9814567 0.727 rs4437193 chr3:134352344 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.51 -16.05 -0.54 6.21e-49 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7772486 0.686 rs4896828 chr6:145953339 A/C cg23711669 chr6:146136114 FBXO30 0.72 17.08 0.56 3.59e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs1941023 0.568 rs1373064 chr11:60168200 C/T cg08716584 chr11:60157161 MS4A7 -0.42 -9.73 -0.36 5.83e-21 Congenital heart disease (maternal effect); BRCA cis rs2455601 0.766 rs1109304 chr11:8955455 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -8.78 -0.33 1.52e-17 Schizophrenia; BRCA cis rs600806 0.713 rs12140694 chr1:109998386 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.3 0.31 6.14e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg27170947 chr2:26402098 FAM59B 0.85 14.09 0.49 1.92e-39 Gut microbiome composition (summer); BRCA cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg01181863 chr3:195395398 SDHAP2 -0.69 -10.69 -0.39 1.16e-24 Pancreatic cancer; BRCA cis rs929596 0.755 rs6742078 chr2:234672639 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.44 11.16 0.4 1.57e-26 Total bilirubin levels in HIV-1 infection; BRCA cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg06618935 chr21:46677482 NA -0.37 -8.11 -0.31 2.52e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg23743428 chr13:21893420 NA -0.38 -8.52 -0.32 1.16e-16 White matter hyperintensity burden; BRCA cis rs9486715 1.000 rs3798297 chr6:97062835 C/T cg06623918 chr6:96969491 KIAA0776 -0.82 -21.97 -0.66 3.93e-80 Headache; BRCA cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.76 -0.33 1.81e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4919087 1.000 rs10786326 chr10:99070377 G/A cg25902810 chr10:99078978 FRAT1 0.52 11.67 0.42 1.17e-28 Monocyte count; BRCA cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.07 -0.46 9.29e-35 Chronic sinus infection; BRCA cis rs11051970 0.655 rs10771942 chr12:32528488 G/A cg24626660 chr12:32551988 NA 0.28 8.12 0.31 2.35e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs74181299 0.750 rs1420185 chr2:65315903 A/G cg05010058 chr2:65284262 CEP68 0.31 8.39 0.32 3.1e-16 Pulse pressure; BRCA cis rs1153858 1.000 rs12440038 chr15:45706739 A/G cg14582100 chr15:45693742 SPATA5L1 0.37 11.84 0.42 2.32e-29 Homoarginine levels; BRCA cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.26e-14 Depression; BRCA cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg11584989 chr19:19387371 SF4 0.6 12.28 0.44 2.87e-31 Bipolar disorder; BRCA cis rs939658 0.567 rs11631829 chr15:79446529 C/T cg17916960 chr15:79447300 NA -0.4 -10.44 -0.38 1.19e-23 Refractive error; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.72 -0.33 2.38e-17 Total body bone mineral density; BRCA cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.83 0.39 3.19e-25 Bipolar disorder; BRCA cis rs6964587 1.000 rs10225885 chr7:91671007 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.12 0.31 2.38e-15 Breast cancer; BRCA cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg08219700 chr8:58056026 NA 0.45 8.08 0.3 3.2e-15 Developmental language disorder (linguistic errors); BRCA trans rs2832077 0.527 rs2250141 chr21:30241984 A/T cg14791747 chr16:20752902 THUMPD1 -0.4 -12.33 -0.44 1.74e-31 Cognitive test performance; BRCA cis rs11971779 0.646 rs58682779 chr7:139084712 C/T cg07862535 chr7:139043722 LUC7L2 0.53 12.86 0.45 8.01e-34 Diisocyanate-induced asthma; BRCA cis rs2425143 0.818 rs7272684 chr20:34424692 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.12 -0.31 2.49e-15 Blood protein levels; BRCA trans rs11976180 1.000 rs2371247 chr7:143764179 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.39 -0.32 3.16e-16 Obesity-related traits; BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg26031613 chr14:104095156 KLC1 -0.44 -8.73 -0.33 2.22e-17 Schizophrenia; BRCA cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg17971929 chr21:40555470 PSMG1 -0.63 -14.21 -0.49 4.99e-40 Cognitive function; BRCA cis rs2070488 1.000 rs7373816 chr3:38490443 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.38 0.63 1.62e-71 Electrocardiographic conduction measures; BRCA cis rs7828089 0.934 rs12544427 chr8:22263115 C/T cg12081754 chr8:22256438 SLC39A14 -0.39 -8.04 -0.3 4.41e-15 Verbal declarative memory; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg02353165 chr6:42928485 GNMT 0.92 26.29 0.72 7.98e-104 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg04450456 chr4:17643702 FAM184B 0.37 10.9 0.4 1.68e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10267417 0.589 rs6960989 chr7:19869349 G/A cg07541023 chr7:19748670 TWISTNB 0.51 9.17 0.34 6.47e-19 Night sleep phenotypes; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg08888203 chr3:10149979 C3orf24 0.64 11.9 0.43 1.24e-29 Alzheimer's disease; BRCA cis rs7524258 0.903 rs4908609 chr1:7292910 G/A cg07173049 chr1:7289937 CAMTA1 0.55 13.54 0.47 6.48e-37 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs11971779 0.680 rs3924445 chr7:139044172 C/A cg07862535 chr7:139043722 LUC7L2 0.38 10.37 0.38 2.13e-23 Diisocyanate-induced asthma; BRCA cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.11 0.43 1.62e-30 Lung cancer in ever smokers; BRCA cis rs10924970 0.934 rs56681442 chr1:235466800 G/A cg26050004 chr1:235667680 B3GALNT2 0.33 8.22 0.31 1.14e-15 Asthma; BRCA cis rs10046574 0.561 rs6966294 chr7:135196479 G/A cg27474649 chr7:135195673 CNOT4 0.66 10.84 0.39 3.11e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs858239 0.669 rs12539467 chr7:23115859 A/G cg23682824 chr7:23144976 KLHL7 0.42 10.8 0.39 4.53e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.8 -0.62 2.12e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.55 0.39 4.26e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2933343 0.533 rs11915889 chr3:128700866 A/C cg11901034 chr3:128598214 ACAD9 -0.34 -8.08 -0.3 3.31e-15 IgG glycosylation; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg21280719 chr6:42927975 GNMT -0.33 -13.94 -0.48 9.74e-39 Plasma homocysteine levels (post-methionine load test); BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg00149659 chr3:10157352 C3orf10 0.8 13.78 0.48 5.12e-38 Alzheimer's disease; BRCA cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg08213375 chr14:104286397 PPP1R13B 0.63 17.1 0.56 2.85e-54 Schizophrenia; BRCA cis rs12579753 0.956 rs11115039 chr12:82217338 A/C cg07988820 chr12:82153109 PPFIA2 -0.6 -9.7 -0.36 7.72e-21 Resting heart rate; BRCA cis rs4363385 0.720 rs6680624 chr1:152983872 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.14 -0.34 8.11e-19 Inflammatory skin disease; BRCA cis rs2243480 0.803 rs36004293 chr7:65416512 T/C cg18252515 chr7:66147081 NA -0.82 -11.87 -0.42 1.69e-29 Diabetic kidney disease; BRCA cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg25427524 chr10:38739819 LOC399744 -0.7 -16.88 -0.56 4.06e-53 Extrinsic epigenetic age acceleration; BRCA cis rs4891159 0.790 rs690619 chr18:74108744 A/G cg24786174 chr18:74118243 ZNF516 0.73 17.99 0.58 7.89e-59 Longevity; BRCA cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.84 -0.45 1.03e-33 Bipolar disorder; BRCA cis rs2832191 0.671 rs2409332 chr21:30512779 G/A cg24692254 chr21:30365293 RNF160 -0.46 -10.19 -0.37 1.11e-22 Dental caries; BRCA cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.38 -8.17 -0.31 1.67e-15 IgG glycosylation; BRCA cis rs1401999 0.724 rs1016752 chr3:183665062 C/G cg20387954 chr3:183756860 HTR3D -0.5 -10.61 -0.39 2.52e-24 Anterior chamber depth; BRCA cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.49e-52 Extrinsic epigenetic age acceleration; BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg08805041 chr16:621841 PIGQ -0.29 -7.92 -0.3 1.05e-14 Height; BRCA trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.9 -0.3 1.26e-14 Corneal astigmatism; BRCA cis rs1005277 0.522 rs9418276 chr10:37940116 G/T cg25427524 chr10:38739819 LOC399744 -0.64 -14.77 -0.5 1.08e-42 Extrinsic epigenetic age acceleration; BRCA cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22307029 chr19:49891270 CCDC155 0.63 11.57 0.42 3.05e-28 Multiple sclerosis; BRCA cis rs3806843 0.766 rs2251860 chr5:140048209 T/C cg11822812 chr5:140052017 DND1 -0.32 -8.92 -0.33 4.91e-18 Depressive symptoms (multi-trait analysis); BRCA cis rs7560272 0.723 rs4852927 chr2:73641557 C/T cg20560298 chr2:73613845 ALMS1 0.42 11.33 0.41 3.06e-27 Schizophrenia; BRCA cis rs17209837 0.607 rs4148816 chr7:87087731 G/A cg00919237 chr7:87102261 ABCB4 -0.53 -10.2 -0.37 9.44e-23 Gallbladder cancer; BRCA cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg18876405 chr7:65276391 NA 0.51 11.4 0.41 1.57e-27 Aortic root size; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.97 0.48 7.06e-39 Platelet count; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg22920501 chr2:26401640 FAM59B -0.9 -16.59 -0.55 1.12e-51 Gut microbiome composition (summer); BRCA cis rs7020830 0.825 rs66684257 chr9:37199087 G/T cg14294708 chr9:37120828 ZCCHC7 1.05 31.55 0.78 1.91e-132 Schizophrenia; BRCA cis rs7666738 0.830 rs2015828 chr4:98984594 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.59 0.55 1.12e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs722599 0.748 rs20578 chr14:75367807 C/T cg08847533 chr14:75593920 NEK9 -0.44 -8.0 -0.3 6.06e-15 IgG glycosylation; BRCA cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg16586182 chr3:47516702 SCAP -0.56 -12.34 -0.44 1.52e-31 Colorectal cancer; BRCA cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg19901468 chr14:105411992 AHNAK2 -0.51 -12.37 -0.44 1.15e-31 Rheumatoid arthritis; BRCA cis rs11605924 0.901 rs11038672 chr11:45846498 C/G ch.11.939596F chr11:45881766 CRY2 -0.43 -9.54 -0.35 3.08e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2153535 0.601 rs9505451 chr6:8469950 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg14829155 chr15:31115871 NA -0.43 -9.79 -0.36 3.66e-21 Huntington's disease progression; BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 1.95e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg08109568 chr15:31115862 NA 0.42 10.14 0.37 1.63e-22 Huntington's disease progression; BRCA cis rs7917772 0.582 rs4285804 chr10:104386309 T/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.43 -12.58 -0.45 1.38e-32 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.12 0.4 2.2e-26 Bipolar disorder; BRCA cis rs1065852 0.526 rs11090066 chr22:42398195 A/G cg22189786 chr22:42395067 WBP2NL 0.4 8.06 0.3 3.69e-15 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs6120849 0.754 rs6120804 chr20:33623701 C/A cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs832540 1.000 rs252913 chr5:56195846 C/T cg24531977 chr5:56204891 C5orf35 0.4 8.16 0.31 1.84e-15 Coronary artery disease; BRCA cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg15017067 chr4:17643749 FAM184B 0.32 9.36 0.35 1.28e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9325144 0.647 rs12822023 chr12:39097964 T/C cg26384229 chr12:38710491 ALG10B -0.48 -11.25 -0.41 6.27e-27 Morning vs. evening chronotype; BRCA trans rs6582630 0.502 rs4379906 chr12:38295673 G/A cg06521331 chr12:34319734 NA -0.47 -9.18 -0.34 6.09e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs12681288 0.645 rs2600509 chr8:989022 C/G cg04851639 chr8:1020857 NA 0.36 10.09 0.37 2.58e-22 Schizophrenia; BRCA cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.74e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs13394619 0.775 rs10165819 chr2:11722102 A/T cg07314298 chr2:11723111 GREB1 -0.56 -12.46 -0.44 4.86e-32 Endometriosis; BRCA cis rs11098499 0.542 rs7677836 chr4:120310638 T/A cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg10523679 chr1:76189770 ACADM 0.77 15.55 0.52 1.8e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs28735056 0.609 rs4799099 chr18:77639585 A/G cg20368463 chr18:77673604 PQLC1 0.4 10.18 0.37 1.18e-22 Schizophrenia; BRCA cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.15e-23 Motion sickness; BRCA cis rs16867321 0.694 rs721301 chr2:181387265 A/G cg23363182 chr2:181467187 NA 0.39 8.16 0.31 1.81e-15 Obesity; BRCA cis rs12493885 0.818 rs61791545 chr3:153768888 G/A cg17054900 chr3:154042577 DHX36 -0.49 -8.56 -0.32 8.68e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA trans rs12517041 1.000 rs6890216 chr5:23299559 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs6964587 0.967 rs12531966 chr7:91765840 A/G cg22117172 chr7:91764530 CYP51A1 0.24 8.35 0.31 4.19e-16 Breast cancer; BRCA cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.57 0.39 3.58e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.27 0.31 8e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1577917 0.958 rs9647601 chr6:86449827 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.67 -0.42 1.15e-28 Response to antipsychotic treatment; BRCA cis rs17401966 0.931 rs2236678 chr1:10471789 A/T cg03954927 chr1:10346856 KIF1B 0.47 14.12 0.49 1.34e-39 Hepatocellular carcinoma; BRCA cis rs7568458 0.783 rs1561198 chr2:85809989 C/T cg02493740 chr2:85810744 VAMP5 -0.39 -8.43 -0.32 2.34e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7474896 0.515 rs688608 chr10:38331624 G/A cg25427524 chr10:38739819 LOC399744 0.58 9.92 0.37 1.14e-21 Obesity (extreme); BRCA cis rs6570726 0.935 rs413916 chr6:145831400 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.15 0.51 1.6e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs17027102 chr4:98919221 A/G cg05340658 chr4:99064831 C4orf37 -0.65 -16.01 -0.54 9.04e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs11711311 1.000 rs9828099 chr3:113518402 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.74 -0.36 5.24e-21 IgG glycosylation; BRCA cis rs2882667 0.858 rs11750382 chr5:138456994 A/G cg04439458 chr5:138467593 SIL1 0.43 11.08 0.4 3.24e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1401999 0.510 rs2293001 chr3:183700211 C/T cg01324343 chr3:183735012 ABCC5 0.48 10.83 0.39 3.2e-25 Anterior chamber depth; BRCA cis rs9341808 0.527 rs2505946 chr6:80810683 A/G cg08355045 chr6:80787529 NA 0.49 13.59 0.47 4.1e-37 Sitting height ratio; BRCA cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.45e-35 Aortic root size; BRCA trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg08975724 chr8:8085496 FLJ10661 0.41 8.35 0.31 4.27e-16 Triglycerides; BRCA cis rs739401 0.611 rs572373 chr11:3055361 T/C cg25174290 chr11:3078921 CARS 0.46 14.01 0.48 4.32e-39 Longevity; BRCA cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.92 0.6 1.04e-63 Cognitive function; BRCA cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11890956 chr21:40555474 PSMG1 1.05 29.82 0.76 4.41e-123 Cognitive function; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg15112475 chr7:1198522 ZFAND2A -0.41 -8.85 -0.33 8.65e-18 Longevity;Endometriosis; BRCA cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg11062466 chr8:58055876 NA 0.42 8.02 0.3 5.19e-15 Developmental language disorder (linguistic errors); BRCA trans rs2262909 0.962 rs73019844 chr19:22249925 T/C cg17074339 chr11:11642133 GALNTL4 0.42 8.14 0.31 2.13e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg15839431 chr19:19639596 YJEFN3 -0.41 -9.15 -0.34 7.53e-19 Bipolar disorder; BRCA cis rs208520 1.000 rs208536 chr6:66963440 T/C cg07460842 chr6:66804631 NA -0.86 -14.3 -0.49 1.93e-40 Exhaled nitric oxide output; BRCA cis rs8062405 1.000 rs4788099 chr16:28855727 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.4e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.46 -8.97 -0.33 3.28e-18 Lung cancer in ever smokers; BRCA cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11644478 chr21:40555479 PSMG1 -0.65 -13.86 -0.48 2.21e-38 Cognitive function; BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg08470875 chr2:26401718 FAM59B -0.51 -8.56 -0.32 8.5e-17 Gut microbiome composition (summer); BRCA cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg24920358 chr1:40204285 PPIE 0.34 7.89 0.3 1.32e-14 Blood protein levels; BRCA cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg01262667 chr19:19385393 TM6SF2 -0.41 -10.72 -0.39 9.03e-25 Tonsillectomy; BRCA cis rs11920090 0.720 rs5394 chr3:170744893 G/A cg09710316 chr3:170744871 SLC2A2 0.64 10.46 0.38 1e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs2425143 1.000 rs13038622 chr20:34319343 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA cis rs11051970 0.879 rs950079 chr12:32588620 A/G cg02745156 chr12:32552066 NA 0.27 8.87 0.33 7.25e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs3809566 1.000 rs10851721 chr15:63332383 T/C cg05507819 chr15:63340323 TPM1 0.43 9.15 0.34 7.29e-19 Platelet count; BRCA cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.77 0.36 4.11e-21 Bipolar disorder; BRCA cis rs113835537 0.529 rs61561111 chr11:66275923 T/C cg24851651 chr11:66362959 CCS 0.43 8.24 0.31 9.69e-16 Airway imaging phenotypes; BRCA cis rs933688 1.000 rs985434 chr5:90744509 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.03 0.54 7.54e-49 Smoking behavior; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.21 -0.54 9.83e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg06108461 chr20:60628389 TAF4 -0.74 -15.69 -0.53 3.54e-47 Body mass index; BRCA cis rs1538970 0.810 rs12067642 chr1:45927517 G/T cg05343316 chr1:45956843 TESK2 0.62 12.57 0.45 1.58e-32 Platelet count; BRCA cis rs2303759 0.881 rs10412811 chr19:49884495 G/A cg22307029 chr19:49891270 CCDC155 0.58 9.97 0.37 7.39e-22 Multiple sclerosis; BRCA trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg25482853 chr8:67687455 SGK3 1.05 16.94 0.56 1.94e-53 Lung disease severity in cystic fibrosis; BRCA cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg06115741 chr20:33292138 TP53INP2 0.47 10.54 0.38 4.69e-24 Coronary artery disease; BRCA cis rs425277 1.000 rs262647 chr1:2095699 C/T cg24578937 chr1:2090814 PRKCZ 0.57 17.86 0.58 3.77e-58 Height; BRCA cis rs853679 0.517 rs9380059 chr6:28132358 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs11971779 0.590 rs59602547 chr7:139117023 G/A cg07862535 chr7:139043722 LUC7L2 0.39 10.58 0.39 3.14e-24 Diisocyanate-induced asthma; BRCA cis rs9814567 0.929 rs9838834 chr3:134207077 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.25 -0.34 3.32e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg12658694 chr1:38397304 INPP5B 0.47 11.37 0.41 1.99e-27 Coronary artery disease; BRCA cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg04267008 chr7:1944627 MAD1L1 -0.57 -12.88 -0.45 6.28e-34 Autism spectrum disorder or schizophrenia; BRCA cis rs17604090 0.793 rs17136535 chr7:29689158 C/T cg19413766 chr7:29689036 LOC646762 -0.51 -8.3 -0.31 6.09e-16 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs17253792 0.822 rs10137340 chr14:56050989 A/G cg01858014 chr14:56050164 KTN1 -0.76 -11.33 -0.41 2.96e-27 Putamen volume; BRCA cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg11814155 chr7:99998594 ZCWPW1 0.49 8.77 0.33 1.57e-17 Platelet count; BRCA cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg21573476 chr21:45109991 RRP1B -0.34 -9.12 -0.34 9.35e-19 Mean corpuscular volume; BRCA cis rs116095464 0.558 rs10065584 chr5:253997 G/A cg22857025 chr5:266934 NA -1.05 -20.18 -0.62 1.99e-70 Breast cancer; BRCA cis rs11971779 0.680 rs2355783 chr7:139075879 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs921968 0.542 rs630858 chr2:219409689 C/A cg10223061 chr2:219282414 VIL1 -0.27 -8.14 -0.31 2.13e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.72 15.24 0.52 5.94e-45 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.94 21.69 0.65 1.35e-78 Smoking behavior; BRCA cis rs1707322 0.963 rs9787412 chr1:46371596 C/T cg03146154 chr1:46216737 IPP 0.45 10.04 0.37 4.15e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg06636001 chr8:8085503 FLJ10661 -0.54 -11.33 -0.41 3.04e-27 Neuroticism; BRCA cis rs7587476 0.906 rs17487827 chr2:215644335 C/G cg04004882 chr2:215674386 BARD1 0.57 10.35 0.38 2.5e-23 Neuroblastoma; BRCA trans rs2832077 0.689 rs2832055 chr21:30132382 C/G cg14791747 chr16:20752902 THUMPD1 -0.33 -9.12 -0.34 9.35e-19 Cognitive test performance; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.03 0.34 1.99e-18 Alzheimer's disease; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg25036284 chr2:26402008 FAM59B -0.89 -15.1 -0.51 2.72e-44 Gut microbiome composition (summer); BRCA cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.82 -0.3 2.16e-14 Aortic root size; BRCA cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.652 rs11513964 chr12:37998214 C/G cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.86e-54 Bladder cancer; BRCA cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg09184832 chr6:79620586 NA -0.41 -8.16 -0.31 1.77e-15 Intelligence (multi-trait analysis); BRCA cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12826209 chr6:26865740 GUSBL1 0.59 10.31 0.38 3.81e-23 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs11105298 0.891 rs10858898 chr12:89922111 A/G cg00757033 chr12:89920650 WDR51B 0.54 10.79 0.39 4.93e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs8077889 0.672 rs1230400 chr17:41845451 G/A cg26893861 chr17:41843967 DUSP3 -0.95 -24.78 -0.7 1.65e-95 Triglycerides; BRCA cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.77 0.33 1.65e-17 Motion sickness; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs9287719 0.967 rs4470306 chr2:10743998 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs3812049 0.737 rs1993878 chr5:127476971 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.57 10.61 0.39 2.46e-24 Lymphocyte counts;Red cell distribution width; BRCA cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA trans rs2197308 0.765 rs12370231 chr12:37917881 T/C cg06521331 chr12:34319734 NA -0.53 -9.49 -0.35 4.44e-20 Morning vs. evening chronotype; BRCA cis rs2559856 0.903 rs10128996 chr12:102081498 G/A cg12924262 chr12:102091054 CHPT1 0.36 8.12 0.31 2.42e-15 Blood protein levels; BRCA cis rs7666738 0.546 rs7679681 chr4:98882221 A/G cg05340658 chr4:99064831 C4orf37 0.55 10.68 0.39 1.26e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.931 rs10939733 chr4:17570658 T/C cg04450456 chr4:17643702 FAM184B 0.41 11.91 0.43 1.14e-29 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.4e-77 Mean platelet volume; BRCA cis rs113835537 0.529 rs11227500 chr11:66273233 T/C cg24851651 chr11:66362959 CCS 0.44 8.36 0.31 3.81e-16 Airway imaging phenotypes; BRCA cis rs7824557 0.628 rs11782706 chr8:11186215 A/C cg21775007 chr8:11205619 TDH 0.73 16.3 0.54 3.22e-50 Retinal vascular caliber; BRCA cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg21573476 chr21:45109991 RRP1B -0.35 -9.28 -0.34 2.66e-19 Mean corpuscular volume; BRCA cis rs113835537 0.597 rs10896129 chr11:66338300 T/C cg24851651 chr11:66362959 CCS 0.45 8.59 0.32 6.55e-17 Airway imaging phenotypes; BRCA trans rs9291683 0.588 rs2240724 chr4:10021290 G/C cg26043149 chr18:55253948 FECH 0.4 8.53 0.32 1.06e-16 Bone mineral density; BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 11.91 0.43 1.15e-29 Height; BRCA cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg12756686 chr19:29218302 NA 0.62 12.75 0.45 2.4e-33 Methadone dose in opioid dependence; BRCA trans rs2204008 0.774 rs9669565 chr12:38294428 C/A cg06521331 chr12:34319734 NA -0.47 -8.83 -0.33 1.02e-17 Bladder cancer; BRCA cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg16586182 chr3:47516702 SCAP -0.46 -9.22 -0.34 4.37e-19 Birth weight; BRCA cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg08085267 chr17:45401833 C17orf57 0.69 15.43 0.52 7.08e-46 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg24846343 chr22:24311635 DDTL 0.57 14.85 0.51 4.6e-43 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg18876405 chr7:65276391 NA -0.64 -15.59 -0.52 1.12e-46 Aortic root size; BRCA cis rs7267979 1.000 rs6050542 chr20:25318879 T/C cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9815354 0.812 rs73081372 chr3:41917993 C/T cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs400736 0.930 rs226249 chr1:8021778 A/G cg25007680 chr1:8021821 PARK7 0.5 12.75 0.45 2.57e-33 Response to antidepressants and depression; BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg01262667 chr19:19385393 TM6SF2 -0.42 -10.69 -0.39 1.23e-24 Tonsillectomy; BRCA cis rs2797160 1.000 rs1777226 chr6:126017691 C/A cg05901451 chr6:126070800 HEY2 0.4 9.62 0.36 1.48e-20 Endometrial cancer; BRCA cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg05234568 chr11:5960015 NA -0.49 -10.28 -0.38 4.69e-23 DNA methylation (variation); BRCA cis rs1784581 0.802 rs6455787 chr6:162411378 G/A cg17173639 chr6:162384350 PARK2 0.39 9.11 0.34 1.08e-18 Itch intensity from mosquito bite; BRCA trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.95 0.3 8.6e-15 Corneal astigmatism; BRCA cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg05347473 chr6:146136440 FBXO30 -0.4 -7.9 -0.3 1.2e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs3916 1.000 rs2014355 chr12:121175524 A/G cg21892295 chr12:121157589 UNC119B -0.33 -7.99 -0.3 6.12e-15 Urinary metabolites (H-NMR features); BRCA cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.93 0.33 4.43e-18 Motion sickness; BRCA cis rs701145 0.585 rs1727880 chr3:153835972 G/A cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.2e-14 Coronary artery disease; BRCA cis rs35146811 0.555 rs2525539 chr7:99545309 A/G cg22906224 chr7:99728672 NA -0.42 -7.97 -0.3 7.32e-15 Coronary artery disease; BRCA cis rs2191566 0.540 rs436739 chr19:44495553 A/G cg20607764 chr19:44506953 ZNF230 0.4 8.68 0.32 3.21e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs7833986 0.941 rs13278255 chr8:57067975 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.41 0.32 2.66e-16 Height; BRCA cis rs7258465 0.965 rs1560118 chr19:18570035 G/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.93 -0.33 4.55e-18 Breast cancer; BRCA cis rs10193935 0.792 rs6735571 chr2:42491951 C/T cg27598129 chr2:42591480 NA -0.58 -9.81 -0.36 2.94e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.65 13.88 0.48 1.78e-38 Lymphocyte counts; BRCA cis rs701145 0.585 rs1727940 chr3:153827257 C/G cg17054900 chr3:154042577 DHX36 0.5 8.6 0.32 6.24e-17 Coronary artery disease; BRCA cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg23711669 chr6:146136114 FBXO30 0.73 16.94 0.56 1.97e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7044106 0.791 rs2416798 chr9:123480603 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.68 15.05 0.51 5.12e-44 Hip circumference adjusted for BMI; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.76 16.96 0.56 1.54e-53 Lymphocyte counts; BRCA cis rs34779708 0.966 rs1057108 chr10:35484949 T/G cg03585969 chr10:35415529 CREM 0.48 10.06 0.37 3.33e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.74 0.39 7.82e-25 Tonsillectomy; BRCA cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg26647111 chr11:31128758 NA -0.43 -9.68 -0.36 8.93e-21 Red blood cell count; BRCA cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg14784868 chr12:69753453 YEATS4 0.51 12.54 0.44 2.18e-32 Blood protein levels; BRCA cis rs17270561 0.636 rs10946793 chr6:25699999 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.51 0.32 1.23e-16 Iron status biomarkers; BRCA cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg02743256 chr7:2109353 MAD1L1 -0.44 -8.31 -0.31 5.69e-16 Bipolar disorder; BRCA cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg12311346 chr5:56204834 C5orf35 -0.8 -15.68 -0.53 4.12e-47 Initial pursuit acceleration; BRCA cis rs6138458 0.626 rs6132789 chr20:25012809 C/T cg26195577 chr20:24973756 C20orf3 -0.61 -14.73 -0.5 1.62e-42 Blood protein levels; BRCA cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg11764359 chr7:65958608 NA -0.75 -16.84 -0.55 6.4e-53 Aortic root size; BRCA trans rs75804782 0.521 rs55915157 chr2:239424273 T/C cg01134436 chr17:81009848 B3GNTL1 0.57 8.13 0.31 2.19e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.46 0.41 9.01e-28 Bipolar disorder; BRCA cis rs6570726 0.905 rs388728 chr6:145816419 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.05 0.51 4.81e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs8017423 0.904 rs11623741 chr14:90804474 C/T cg04374321 chr14:90722782 PSMC1 0.72 18.83 0.6 2.97e-63 Mortality in heart failure; BRCA cis rs8077889 1.000 rs113919636 chr17:41877740 A/C cg26893861 chr17:41843967 DUSP3 0.67 12.74 0.45 2.86e-33 Triglycerides; BRCA cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg24558204 chr6:135376177 HBS1L 0.6 15.96 0.53 1.59e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs208520 0.690 rs207091 chr6:66799847 G/T cg07460842 chr6:66804631 NA -1.0 -20.02 -0.62 1.44e-69 Exhaled nitric oxide output; BRCA trans rs35110281 0.776 rs2838316 chr21:44990036 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.4 0.38 1.64e-23 Mean corpuscular volume; BRCA cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.89 -0.33 6.27e-18 Alzheimer's disease (late onset); BRCA cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 8.7 0.33 2.73e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs2262909 0.962 rs55735642 chr19:22241176 C/T cg17074339 chr11:11642133 GALNTL4 0.42 8.11 0.31 2.68e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg17971929 chr21:40555470 PSMG1 -0.63 -14.04 -0.49 3.05e-39 Cognitive function; BRCA cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg03433033 chr1:76189801 ACADM -0.59 -11.81 -0.42 2.98e-29 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs853679 0.607 rs34878803 chr6:28250179 T/C cg06606381 chr12:133084897 FBRSL1 -0.78 -8.32 -0.31 5.37e-16 Depression; BRCA cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg11663144 chr21:46675770 NA 0.56 12.96 0.46 2.76e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs34779708 0.931 rs4934693 chr10:35271844 G/A cg03585969 chr10:35415529 CREM 0.55 11.23 0.41 7.64e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg04013166 chr16:89971882 TCF25 0.52 9.52 0.35 3.4e-20 Skin colour saturation; BRCA cis rs7149337 0.804 rs4131981 chr14:51667504 A/T cg23942311 chr14:51606299 NA -0.4 -11.38 -0.41 1.81e-27 Cancer; BRCA cis rs11098499 0.739 rs10013032 chr4:120149419 C/T cg09307838 chr4:120376055 NA -0.49 -9.27 -0.34 2.75e-19 Corneal astigmatism; BRCA cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg00074818 chr8:8560427 CLDN23 0.38 8.44 0.32 2.08e-16 Obesity-related traits; BRCA trans rs9944715 0.911 rs7230995 chr18:43786822 G/A cg01718231 chr17:29326311 RNF135 -0.46 -9.05 -0.34 1.76e-18 Red cell distribution width;Mean corpuscular volume; BRCA trans rs877282 1.000 rs11253366 chr10:773386 C/T cg22713356 chr15:30763199 NA 1.16 23.63 0.68 3.16e-89 Uric acid levels; BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg07343612 chr16:622815 PIGQ -0.66 -21.57 -0.65 5.92e-78 Height; BRCA cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg08807101 chr21:30365312 RNF160 0.39 8.39 0.32 3.1e-16 Pancreatic cancer; BRCA cis rs17401966 0.867 rs10492973 chr1:10398985 T/C cg19773385 chr1:10388646 KIF1B -0.35 -7.86 -0.3 1.66e-14 Hepatocellular carcinoma; BRCA cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg18198730 chr1:247681584 NA 0.49 11.23 0.41 8.03e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg20573242 chr4:122745356 CCNA2 0.44 9.58 0.35 2.06e-20 Type 2 diabetes; BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg20219911 chr3:52813652 ITIH1 0.29 8.0 0.3 5.99e-15 Electroencephalogram traits; BRCA cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg16989086 chr20:62203971 PRIC285 0.52 8.77 0.33 1.63e-17 Glioblastoma; BRCA cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg10370574 chr19:1840461 REXO1 -0.38 -8.51 -0.32 1.27e-16 Bipolar disorder; BRCA cis rs77861329 1.000 rs9868101 chr3:52138377 T/C cg08692210 chr3:52188851 WDR51A 0.69 10.67 0.39 1.49e-24 Macrophage inflammatory protein 1b levels; BRCA trans rs1493916 0.837 rs9949631 chr18:31410567 G/A cg15819921 chr19:927150 ARID3A -0.41 -8.07 -0.3 3.37e-15 Life satisfaction; BRCA cis rs826838 1.000 rs11183214 chr12:38692938 C/T cg13010199 chr12:38710504 ALG10B 0.59 13.03 0.46 1.44e-34 Heart rate; BRCA cis rs10493773 0.566 rs11161659 chr1:86183967 T/C cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.39 -0.47 3.18e-36 Urate levels in overweight individuals; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00166722 chr3:10149974 C3orf24 0.66 13.26 0.46 1.29e-35 Alzheimer's disease; BRCA cis rs17092148 0.848 rs6060030 chr20:33340313 C/T cg16810054 chr20:33298113 TP53INP2 -0.41 -9.57 -0.35 2.27e-20 Neuroticism; BRCA cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg12292205 chr6:26970375 C6orf41 0.73 16.79 0.55 1.14e-52 Autism spectrum disorder or schizophrenia; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg10729496 chr3:10149963 C3orf24 0.49 9.06 0.34 1.51e-18 Alzheimer's disease; BRCA trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg03929089 chr4:120376271 NA -0.73 -15.85 -0.53 5.5e-48 Coronary artery disease; BRCA cis rs7598759 0.966 rs6754426 chr2:232322779 G/A cg19187155 chr2:232395269 NMUR1 0.41 8.9 0.33 5.62e-18 Noise-induced hearing loss; BRCA cis rs1348850 0.914 rs10497503 chr2:178371739 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 8.43 0.32 2.29e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9399135 0.967 rs6929661 chr6:135328792 G/A cg24558204 chr6:135376177 HBS1L 0.46 12.61 0.45 9.93e-33 Red blood cell count; BRCA trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21659725 chr3:3221576 CRBN -0.49 -10.29 -0.38 4.43e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.7 -0.33 2.8e-17 Total body bone mineral density; BRCA cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.06 -0.43 2.59e-30 Tonsillectomy; BRCA cis rs9837602 1.000 rs10212525 chr3:99713377 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.28 0.41 4.85e-27 Breast cancer; BRCA cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg19622623 chr12:86230825 RASSF9 -0.29 -8.2 -0.31 1.37e-15 Major depressive disorder; BRCA cis rs4845875 0.600 rs4846041 chr1:11837051 C/T cg24844545 chr1:11908347 NPPA 0.37 8.68 0.32 3.35e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs736408 0.608 rs2239547 chr3:52855229 T/C cg11645453 chr3:52864694 ITIH4 0.42 10.38 0.38 1.9e-23 Bipolar disorder; BRCA cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg08048268 chr3:133502702 NA -0.34 -8.29 -0.31 6.85e-16 Iron status biomarkers; BRCA cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.5e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4820539 1.000 rs4820539 chr22:23477970 C/T cg14186256 chr22:23484241 RTDR1 -0.72 -20.91 -0.64 2.19e-74 Bone mineral density; BRCA cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6433895 0.961 rs7566434 chr2:182013615 C/T cg00481216 chr2:181971175 NA 0.37 8.72 0.33 2.49e-17 Lymphocyte counts; BRCA cis rs11764590 0.666 rs7787359 chr7:2090849 A/G cg23422044 chr7:1970798 MAD1L1 -0.44 -9.41 -0.35 9.01e-20 Neuroticism; BRCA cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg13073564 chr4:8508604 NA 0.45 12.51 0.44 2.82e-32 Response to antineoplastic agents; BRCA trans rs6600671 1.000 rs7532615 chr1:121172840 G/T cg17023122 chr1:144479586 NA -0.32 -7.82 -0.3 2.14e-14 Hip geometry; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg16606324 chr3:10149918 C3orf24 0.49 9.81 0.36 2.97e-21 Alzheimer's disease; BRCA cis rs11122272 0.735 rs2790890 chr1:231514567 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -12.32 -0.44 1.92e-31 Hemoglobin concentration; BRCA cis rs1401999 0.690 rs1402001 chr3:183642751 A/G cg20387954 chr3:183756860 HTR3D 0.36 8.34 0.31 4.46e-16 Anterior chamber depth; BRCA cis rs4800452 0.871 rs9961220 chr18:20733201 G/T cg26136497 chr18:20735537 CABLES1 -0.48 -11.58 -0.42 2.88e-28 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.03 -0.58 4.7e-59 Extrinsic epigenetic age acceleration; BRCA cis rs8062405 1.000 rs72793811 chr16:28839392 G/A cg09754948 chr16:28834200 ATXN2L 0.47 8.77 0.33 1.56e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2070488 0.775 rs7649984 chr3:38570221 C/T cg24069376 chr3:38537580 EXOG -0.3 -8.31 -0.31 5.87e-16 Electrocardiographic conduction measures; BRCA cis rs250677 1.000 rs36082 chr5:148428844 C/G cg12140854 chr5:148520817 ABLIM3 -0.42 -8.79 -0.33 1.32e-17 Breast cancer; BRCA cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg20476274 chr7:133979776 SLC35B4 0.58 14.36 0.49 9.7e-41 Mean platelet volume; BRCA cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg06640241 chr16:89574553 SPG7 0.75 17.73 0.57 1.71e-57 Multiple myeloma (IgH translocation); BRCA cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg24642439 chr20:33292090 TP53INP2 0.7 16.05 0.54 6.09e-49 Coronary artery disease; BRCA trans rs7819412 0.668 rs920047 chr8:11087475 C/T cg15556689 chr8:8085844 FLJ10661 -0.36 -9.63 -0.36 1.34e-20 Triglycerides; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 10.82 0.39 3.49e-25 Platelet count; BRCA cis rs1595825 0.945 rs61184128 chr2:198843659 C/T cg19156104 chr2:198669113 PLCL1 -0.44 -8.22 -0.31 1.13e-15 Ulcerative colitis; BRCA cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg00071950 chr4:10020882 SLC2A9 0.67 16.82 0.55 7.99e-53 Bone mineral density; BRCA cis rs2011503 1.000 rs74950305 chr19:19639448 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 8.85e-19 Bipolar disorder; BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs1371614 0.632 rs12615423 chr2:27158623 G/T cg00617064 chr2:27272375 NA 0.32 8.37 0.31 3.65e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg01884057 chr2:25150051 NA 0.34 8.98 0.33 3.1e-18 Body mass index; BRCA trans rs7786808 0.608 rs7784758 chr7:158214386 A/G cg02030672 chr11:45687055 CHST1 0.39 8.89 0.33 6e-18 Obesity-related traits; BRCA cis rs875971 0.862 rs709596 chr7:65825913 A/G cg18876405 chr7:65276391 NA 0.51 11.76 0.42 4.79e-29 Aortic root size; BRCA cis rs17685 0.712 rs1639620 chr7:75704090 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.85 -0.33 8.3e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs501916 0.634 rs531596 chr15:48058214 C/T cg16110827 chr15:48056943 SEMA6D -0.42 -9.2 -0.34 5.1e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs6942756 1.000 rs11763056 chr7:128960871 C/A cg02491457 chr7:128862824 NA -0.71 -14.04 -0.49 3.18e-39 White matter hyperintensity burden; BRCA cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg16325326 chr1:53192061 ZYG11B -0.65 -16.18 -0.54 1.29e-49 Monocyte count; BRCA cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg10556349 chr10:835070 NA 0.73 9.85 0.36 2.13e-21 Eosinophil percentage of granulocytes; BRCA cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg22862634 chr11:62369728 EML3;MTA2 0.52 12.65 0.45 6.79e-33 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.15 0.31 1.92e-15 Tonsillectomy; BRCA cis rs12291225 0.645 rs3763950 chr11:14278049 T/A cg19336497 chr11:14380999 RRAS2 -0.48 -11.83 -0.42 2.43e-29 Sense of smell; BRCA cis rs4363385 0.693 rs581447 chr1:153033269 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.34 -0.31 4.7e-16 Inflammatory skin disease; BRCA cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg08917208 chr2:24149416 ATAD2B 0.54 8.23 0.31 1.06e-15 Lymphocyte counts; BRCA cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg15103426 chr22:29168792 CCDC117 -0.52 -12.21 -0.43 6e-31 Lymphocyte counts; BRCA cis rs9818758 0.607 rs11719220 chr3:49245201 A/G cg01304814 chr3:48885189 PRKAR2A 0.63 7.91 0.3 1.17e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9970334 0.596 rs709209 chr1:6278414 A/G cg02892189 chr1:6321676 GPR153 -0.37 -8.06 -0.3 3.83e-15 Resting heart rate; BRCA cis rs9815354 0.716 rs73087368 chr3:41930379 A/G cg03022575 chr3:42003672 ULK4 0.69 9.5 0.35 4.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs17539620 0.519 rs12665532 chr6:154835182 C/G cg20019720 chr6:154832845 CNKSR3 0.58 13.36 0.47 4.57e-36 Lipoprotein (a) levels; BRCA cis rs9790314 0.715 rs980975 chr3:160771410 G/A cg03342759 chr3:160939853 NMD3 -0.51 -9.79 -0.36 3.62e-21 Morning vs. evening chronotype; BRCA cis rs3820928 1.000 rs10204368 chr2:227774244 G/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.53e-16 Pulmonary function; BRCA cis rs2629540 0.889 rs7476729 chr10:126428174 C/G cg08799069 chr10:126477246 METTL10 -0.52 -11.25 -0.41 6.77e-27 Cocaine dependence; BRCA cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.55 -12.08 -0.43 2.1000000000000002e-30 Chronic sinus infection; BRCA cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -10.5 -0.38 6.41e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs35146811 0.695 rs858508 chr7:99821381 C/G cg22906224 chr7:99728672 NA -0.43 -8.04 -0.3 4.29e-15 Coronary artery disease; BRCA cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.0 0.3 6.06e-15 Tonsillectomy; BRCA cis rs1707322 1.000 rs11211244 chr1:46456673 G/A cg03146154 chr1:46216737 IPP 0.45 10.06 0.37 3.5e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg05313129 chr8:58192883 C8orf71 -0.45 -9.46 -0.35 5.64e-20 Developmental language disorder (linguistic errors); BRCA cis rs4803468 1.000 rs284655 chr19:41928765 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -23.23 -0.68 5.32e-87 Height; BRCA trans rs116095464 0.558 rs10056628 chr5:279512 G/A cg00938859 chr5:1591904 SDHAP3 0.65 8.91 0.33 5.42e-18 Breast cancer; BRCA cis rs8067545 0.641 rs119672 chr17:19818601 A/G cg04132472 chr17:19861366 AKAP10 0.38 8.85 0.33 8.6e-18 Schizophrenia; BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.58 9.31 0.35 1.98e-19 Alzheimer's disease; BRCA cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg13852791 chr20:30311386 BCL2L1 0.84 16.5 0.55 3.24e-51 Mean corpuscular hemoglobin; BRCA cis rs4363385 0.747 rs12048412 chr1:152977092 A/T cg25856811 chr1:152973957 SPRR3 -0.34 -8.98 -0.33 2.95e-18 Inflammatory skin disease; BRCA cis rs220324 0.688 rs9979344 chr21:43559926 C/T cg09727148 chr21:43560719 UMODL1 0.5 8.88 0.33 6.65e-18 Idiopathic osteonecrosis of the femoral head; BRCA cis rs6964587 0.933 rs10271174 chr7:91785970 A/G cg17063962 chr7:91808500 NA 0.61 14.32 0.49 1.53e-40 Breast cancer; BRCA cis rs68170813 0.559 rs6951639 chr7:106817639 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.49 -0.32 1.47e-16 Coronary artery disease; BRCA cis rs4718428 0.705 rs2901311 chr7:66415069 T/C cg18252515 chr7:66147081 NA -0.51 -9.91 -0.36 1.28e-21 Corneal structure; BRCA cis rs10911232 0.507 rs10752890 chr1:183021910 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.53 0.55 2.33e-51 Hypertriglyceridemia; BRCA cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.75 -0.42 5.3e-29 Colorectal cancer; BRCA cis rs10129255 0.500 rs10143242 chr14:107137831 C/T cg07958169 chr14:107095056 NA -0.38 -8.23 -0.31 1.08e-15 Kawasaki disease; BRCA cis rs1371614 0.632 rs7589627 chr2:27159786 C/T cg00617064 chr2:27272375 NA -0.3 -7.93 -0.3 1.02e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs600806 0.778 rs10494040 chr1:110015732 C/T cg20591472 chr1:110008990 SYPL2 0.31 7.9 0.3 1.25e-14 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg05084668 chr3:125655381 ALG1L -0.5 -9.49 -0.35 4.69e-20 Blood pressure (smoking interaction); BRCA cis rs11030122 0.702 rs2898947 chr11:3977572 G/A cg18678763 chr11:4115507 RRM1 -0.35 -7.97 -0.3 7.29e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg23982607 chr1:1823379 GNB1 0.33 8.05 0.3 4e-15 Body mass index; BRCA cis rs12541635 0.966 rs114386112 chr8:107036340 G/A cg10147462 chr8:107024639 NA 0.37 9.72 0.36 6.56e-21 Age of smoking initiation; BRCA cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg18357645 chr12:58087776 OS9 -0.33 -8.1 -0.31 2.79e-15 Multiple sclerosis; BRCA cis rs7917772 0.636 rs7069489 chr10:104525371 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 10.63 0.39 1.98e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.51 -0.35 3.7e-20 Developmental language disorder (linguistic errors); BRCA cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg11789530 chr4:8429930 ACOX3 -0.46 -10.97 -0.4 9.39e-26 Response to antineoplastic agents; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.54 -0.52 1.93e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs9929218 0.954 rs12599393 chr16:68829021 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.6 -11.91 -0.43 1.09e-29 Colorectal cancer; BRCA cis rs13082711 0.554 rs73055724 chr3:27380397 T/G cg02860705 chr3:27208620 NA 0.66 11.58 0.42 2.68e-28 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs600806 0.821 rs10127790 chr1:109891133 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.17 0.31 1.64e-15 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg21226059 chr5:178986404 RUFY1 0.47 12.61 0.45 1e-32 Lung cancer; BRCA cis rs9790314 0.747 rs1599386 chr3:160856314 C/T cg03342759 chr3:160939853 NMD3 0.54 10.82 0.39 3.46e-25 Morning vs. evening chronotype; BRCA cis rs10782582 0.609 rs1770882 chr1:76411549 G/A cg03433033 chr1:76189801 ACADM -0.4 -8.42 -0.32 2.57e-16 Daytime sleep phenotypes; BRCA cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.48 -0.32 1.53e-16 Aortic root size; BRCA cis rs9818758 0.607 rs80170003 chr3:48951640 T/C cg01304814 chr3:48885189 PRKAR2A 0.71 7.9 0.3 1.26e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg20019365 chr2:219134978 PNKD;AAMP 0.43 9.22 0.34 4.27e-19 Colorectal cancer; BRCA cis rs870825 0.616 rs56844261 chr4:185632478 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA cis rs4595586 0.545 rs12828866 chr12:39391925 C/A cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg02734326 chr4:10020555 SLC2A9 0.39 8.48 0.32 1.61e-16 Bone mineral density; BRCA cis rs12210905 0.688 rs12213533 chr6:27346021 C/T cg08851530 chr6:28072375 NA 0.91 8.7 0.33 2.7e-17 Hip circumference adjusted for BMI; BRCA cis rs312274 0.550 rs11179042 chr12:41311466 C/T cg17827154 chr12:41323612 CNTN1 -0.42 -10.51 -0.38 6.29e-24 Metabolite levels (X-11787); BRCA cis rs2070488 0.931 rs7630012 chr3:38552250 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.73 -19.7 -0.61 7.49e-68 Electrocardiographic conduction measures; BRCA cis rs9503598 0.662 rs2326232 chr6:3451953 A/G cg00476032 chr6:3446245 SLC22A23 0.36 8.99 0.33 2.83e-18 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.65 -0.61 1.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2645694 0.626 rs2645684 chr4:77819892 A/C cg03477792 chr4:77819574 ANKRD56 0.66 15.57 0.52 1.47e-46 Emphysema distribution in smoking; BRCA cis rs6598955 0.671 rs12354062 chr1:26608761 C/T cg00852783 chr1:26633632 UBXN11 -0.47 -7.83 -0.3 1.99e-14 Obesity-related traits; BRCA cis rs117623576 0.680 rs72777120 chr10:32367608 A/G cg03047570 chr10:32398778 NA -0.5 -7.9 -0.3 1.25e-14 Anti-saccade response; BRCA cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg10802521 chr3:52805072 NEK4 -0.32 -8.29 -0.31 6.52e-16 Bipolar disorder; BRCA trans rs637571 0.510 rs3903072 chr11:65583066 G/T cg17712092 chr4:129076599 LARP1B -0.33 -7.9 -0.3 1.27e-14 Eosinophil percentage of white cells; BRCA cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg16145915 chr7:1198662 ZFAND2A -0.4 -9.05 -0.34 1.66e-18 Longevity;Endometriosis; BRCA cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs7824557 0.628 rs7820301 chr8:11228672 G/A cg21775007 chr8:11205619 TDH 0.64 13.88 0.48 1.76e-38 Retinal vascular caliber; BRCA cis rs12310956 0.515 rs1405031 chr12:33958931 A/C cg06521331 chr12:34319734 NA -0.54 -10.88 -0.4 2.15e-25 Morning vs. evening chronotype; BRCA cis rs17401966 0.931 rs11585794 chr1:10443867 G/A cg03954927 chr1:10346856 KIF1B 0.47 14.55 0.5 1.26e-41 Hepatocellular carcinoma; BRCA cis rs2637266 0.846 rs2583045 chr10:78412385 C/G cg18941641 chr10:78392320 NA -0.33 -7.87 -0.3 1.57e-14 Pulmonary function; BRCA cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg24642439 chr20:33292090 TP53INP2 0.53 11.57 0.42 3.01e-28 Glomerular filtration rate (creatinine); BRCA cis rs1355223 0.506 rs7130774 chr11:34869267 A/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.4 -0.35 9.82e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1865760 1.000 rs3799371 chr6:25912816 A/G cg16482183 chr6:26056742 HIST1H1C -0.54 -11.39 -0.41 1.71e-27 Height; BRCA cis rs7937682 0.961 rs4935790 chr11:111633014 T/C cg09085632 chr11:111637200 PPP2R1B 1.01 23.7 0.68 1.34e-89 Primary sclerosing cholangitis; BRCA cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg27165867 chr14:105738592 BRF1 -0.35 -8.35 -0.31 4.17e-16 Mean platelet volume;Platelet distribution width; BRCA trans rs4332037 0.802 rs73048106 chr7:1929019 G/T cg11693508 chr17:37793320 STARD3 0.68 12.43 0.44 6.04e-32 Bipolar disorder; BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13732083 chr21:47605072 C21orf56 0.39 7.98 0.3 6.74e-15 Testicular germ cell tumor; BRCA cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.74 -0.36 5.2e-21 Body mass index; BRCA cis rs992157 0.835 rs12987180 chr2:219144089 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.27 -0.41 5.2e-27 Colorectal cancer; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.72 -0.33 2.44e-17 Total body bone mineral density; BRCA cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg13119609 chr19:45449297 APOC2 0.47 13.08 0.46 8.22e-35 Blood protein levels; BRCA cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg18132916 chr6:79620363 NA -0.49 -11.14 -0.4 1.87e-26 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -8.04 -0.3 4.35e-15 Bipolar disorder and schizophrenia; BRCA cis rs4975616 0.869 rs455433 chr5:1336243 A/G cg07493874 chr5:1342172 CLPTM1L -0.52 -14.99 -0.51 9.47e-44 Lung cancer; BRCA cis rs8180040 0.966 rs11710322 chr3:47331136 C/T cg16586182 chr3:47516702 SCAP 0.61 14.06 0.49 2.58e-39 Colorectal cancer; BRCA cis rs4268898 0.636 rs76172309 chr2:24458911 G/C cg06627628 chr2:24431161 ITSN2 -0.79 -15.05 -0.51 5.04e-44 Asthma; BRCA trans rs11098499 1.000 rs6849889 chr4:120186348 A/C cg25214090 chr10:38739885 LOC399744 0.47 10.3 0.38 4.03e-23 Corneal astigmatism; BRCA cis rs4660306 0.961 rs4660860 chr1:45946233 T/A cg24296786 chr1:45957014 TESK2 0.42 8.39 0.32 3.08e-16 Homocysteine levels; BRCA cis rs9486719 0.895 rs11152960 chr6:96900398 A/G cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.66e-34 Migraine;Coronary artery disease; BRCA cis rs7103648 0.669 rs7114011 chr11:47811309 A/C cg20307385 chr11:47447363 PSMC3 0.73 16.79 0.55 1.06e-52 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs7914558 1.000 rs11191542 chr10:104824324 T/A cg04362960 chr10:104952993 NT5C2 0.42 10.11 0.37 2.18e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs782590 0.935 rs62165197 chr2:55801812 C/T cg18811423 chr2:55921094 PNPT1 0.71 22.76 0.67 1.91e-84 Metabolic syndrome; BRCA cis rs7100689 0.646 rs10788562 chr10:82072310 C/T cg00277334 chr10:82204260 NA 0.42 8.22 0.31 1.17e-15 Post bronchodilator FEV1; BRCA cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg08917208 chr2:24149416 ATAD2B 1.05 14.38 0.49 7.78e-41 Lymphocyte counts; BRCA cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg11764359 chr7:65958608 NA 0.67 15.15 0.51 1.68e-44 Aortic root size; BRCA cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg00071950 chr4:10020882 SLC2A9 -0.49 -10.69 -0.39 1.23e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs587242 0.955 rs4949996 chr1:96965124 A/T cg10631902 chr5:14652156 NA 0.43 10.61 0.39 2.5300000000000002e-24 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs2625529 0.652 rs2957724 chr15:72248474 A/C cg16672083 chr15:72433130 SENP8 0.67 15.9 0.53 3.39e-48 Red blood cell count; BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg27170947 chr2:26402098 FAM59B -0.65 -11.32 -0.41 3.25e-27 Gut microbiome composition (summer); BRCA cis rs7131987 0.675 rs3847678 chr12:29551560 A/C cg09582351 chr12:29534625 ERGIC2 0.38 9.2 0.34 5.04e-19 QT interval; BRCA cis rs7584330 0.518 rs7561919 chr2:238435241 A/G cg08992911 chr2:238395768 MLPH 0.53 8.67 0.32 3.49e-17 Prostate cancer; BRCA cis rs6835098 0.924 rs1991727 chr4:174163169 A/G cg27433088 chr4:174089019 GALNT7 0.28 7.95 0.3 8.32e-15 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1577917 0.958 rs7747897 chr6:86647349 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.91 -0.43 1.07e-29 Response to antipsychotic treatment; BRCA cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.72 -0.33 2.46e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7833986 0.534 rs10504198 chr8:57006254 G/C cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.99 0.46 2.13e-34 Height; BRCA cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg05283184 chr6:79620031 NA -0.43 -11.22 -0.41 8.77e-27 Intelligence (multi-trait analysis); BRCA cis rs4808199 1.000 rs7258508 chr19:19475469 T/C cg03709012 chr19:19516395 GATAD2A 0.99 19.28 0.61 1.26e-65 Nonalcoholic fatty liver disease; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg21280719 chr6:42927975 GNMT -0.33 -14.16 -0.49 8.78e-40 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2806561 0.765 rs641032 chr1:23513980 C/T cg12483005 chr1:23474871 LUZP1 -0.45 -10.1 -0.37 2.37e-22 Height; BRCA cis rs911119 1.000 rs67567111 chr20:23619075 G/T cg16589663 chr20:23618590 CST3 0.47 8.94 0.33 4.25e-18 Chronic kidney disease; BRCA cis rs9790314 0.905 rs6441370 chr3:160993754 C/T cg03342759 chr3:160939853 NMD3 -0.65 -14.03 -0.49 3.36e-39 Morning vs. evening chronotype; BRCA trans rs208520 0.690 rs12192851 chr6:66705862 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 20.27 0.63 6.67e-71 Exhaled nitric oxide output; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg13047869 chr3:10149882 C3orf24 0.53 11.33 0.41 2.9e-27 Alzheimer's disease; BRCA cis rs4722166 0.630 rs7808457 chr7:22798265 A/T cg26061582 chr7:22766209 IL6 -0.42 -9.16 -0.34 6.98e-19 Lung cancer; BRCA cis rs1843834 1.000 rs1843834 chr2:225558042 A/G cg22455342 chr2:225449267 CUL3 0.36 8.56 0.32 8.65e-17 IgE levels in asthmatics (D.p. specific); BRCA cis rs7086627 0.515 rs7077373 chr10:82211615 C/T cg01528321 chr10:82214614 TSPAN14 0.64 14.52 0.5 1.65e-41 Post bronchodilator FEV1; BRCA cis rs1829883 0.931 rs7713876 chr5:98878187 C/G cg08333243 chr5:99726346 NA -0.36 -8.85 -0.33 8.53e-18 Hemostatic factors and hematological phenotypes; BRCA trans rs7939886 0.844 rs17150088 chr11:55894862 T/G cg15704280 chr7:45808275 SEPT13 0.61 7.9 0.3 1.21e-14 Myopia (pathological); BRCA trans rs11165623 0.792 rs12123543 chr1:96964549 T/C cg10631902 chr5:14652156 NA -0.5 -15.88 -0.53 3.94e-48 Hip circumference;Waist circumference; BRCA cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg11279151 chr3:101281821 RG9MTD1 -0.51 -10.48 -0.38 7.77e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs56104184 0.775 rs73061695 chr19:49399988 T/C cg15549821 chr19:49342101 PLEKHA4 -0.67 -9.72 -0.36 6.19e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg25358565 chr5:93447407 FAM172A 1.14 18.13 0.58 1.46e-59 Diabetic retinopathy; BRCA cis rs7666738 0.785 rs11097614 chr4:99092175 G/C cg17366294 chr4:99064904 C4orf37 0.43 8.42 0.32 2.42e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg21143896 chr7:2802374 GNA12 -0.36 -9.18 -0.34 5.97e-19 Height; BRCA cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg18876405 chr7:65276391 NA -0.49 -10.8 -0.39 4.16e-25 Aortic root size; BRCA cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.8 0.39 4.48e-25 Bipolar disorder; BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg02297831 chr4:17616191 MED28 -0.37 -8.42 -0.32 2.54e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs12517041 1.000 rs4547895 chr5:23323269 T/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.05 -0.3 3.91e-15 Calcium levels; BRCA cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg23888215 chr10:79422304 NA -0.55 -10.55 -0.39 4.12e-24 Bone mineral density; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg23978390 chr7:1156363 C7orf50 0.5 11.7 0.42 8.98e-29 Longevity;Endometriosis; BRCA cis rs2777491 1.000 rs2730055 chr15:41735708 C/A cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.03 -0.54 7.19e-49 Ulcerative colitis; BRCA cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.27 -0.54 4.72e-50 Alzheimer's disease (late onset); BRCA cis rs11734570 0.581 rs76682731 chr4:38586045 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.48 8.74 0.33 2.12e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11190604 1.000 rs2273695 chr10:102259568 A/G cg07080220 chr10:102295463 HIF1AN 0.57 13.9 0.48 1.43e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg21782813 chr7:2030301 MAD1L1 0.39 9.92 0.37 1.16e-21 Bipolar disorder and schizophrenia; BRCA cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg26587870 chr6:27730563 NA -0.4 -8.59 -0.32 6.5e-17 Parkinson's disease; BRCA cis rs3772130 0.564 rs35178434 chr3:121595936 G/A cg20356878 chr3:121714668 ILDR1 0.44 10.07 0.37 3.16e-22 Cognitive performance; BRCA trans rs1941687 0.509 rs7230319 chr18:31321289 A/T cg15819921 chr19:927150 ARID3A -0.43 -8.12 -0.31 2.5e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs2197308 0.565 rs12809769 chr12:37909968 C/T cg06521331 chr12:34319734 NA -0.54 -9.73 -0.36 5.73e-21 Morning vs. evening chronotype; BRCA cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg11764359 chr7:65958608 NA 0.67 15.02 0.51 6.93e-44 Aortic root size; BRCA cis rs10046574 0.831 rs7797208 chr7:135137729 C/T cg27474649 chr7:135195673 CNOT4 0.61 8.64 0.32 4.59e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11603020 0.950 rs11229067 chr11:57374946 A/C cg19752551 chr11:57585705 CTNND1 0.43 9.83 0.36 2.53e-21 Blood protein levels; BRCA cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg01579765 chr21:45077557 HSF2BP -0.41 -10.77 -0.39 5.61e-25 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.22 -0.31 1.14e-15 Menopause (age at onset); BRCA cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg18904891 chr8:8559673 CLDN23 0.65 12.97 0.46 2.56e-34 Obesity-related traits; BRCA cis rs1865760 1.000 rs9358893 chr6:25921761 A/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.55 0.39 4.23e-24 Height; BRCA cis rs360798 0.512 rs2430388 chr2:63106784 T/C cg17519650 chr2:63277830 OTX1 0.38 8.13 0.31 2.19e-15 Coronary artery disease; BRCA cis rs6882046 0.513 rs625970 chr5:88042296 A/G cg22951263 chr5:87985283 NA -0.39 -10.85 -0.39 2.7e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs9527 0.615 rs10883810 chr10:104727224 A/C cg04362960 chr10:104952993 NT5C2 0.46 10.64 0.39 1.87e-24 Arsenic metabolism; BRCA cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg19318889 chr4:1322082 MAEA 0.58 11.55 0.42 3.77e-28 Longevity; BRCA cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.15e-23 Motion sickness; BRCA cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg25358565 chr5:93447407 FAM172A 1.18 19.89 0.62 6.63e-69 Diabetic retinopathy; BRCA cis rs2070488 0.965 rs13079145 chr3:38517992 T/G cg24069376 chr3:38537580 EXOG 0.42 11.96 0.43 7.14e-30 Electrocardiographic conduction measures; BRCA cis rs2806561 0.704 rs674386 chr1:23521835 G/A cg12483005 chr1:23474871 LUZP1 0.48 10.49 0.38 7.26e-24 Height; BRCA cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg21770322 chr7:97807741 LMTK2 0.43 11.28 0.41 4.71e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs17685 0.625 rs1639630 chr7:75730499 T/C cg19862616 chr7:65841803 NCRNA00174 0.84 27.31 0.73 1.94e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22455342 chr2:225449267 CUL3 -0.66 -17.09 -0.56 3.37e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs754466 0.606 rs11002306 chr10:79591519 A/T cg17075019 chr10:79541650 NA -0.81 -21.35 -0.65 1e-76 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg07262247 chr5:131593730 PDLIM4 0.36 8.06 0.3 3.68e-15 Acylcarnitine levels; BRCA cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.1 -0.31 2.84e-15 Depression; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.82 -12.38 -0.44 1.05e-31 Platelet count; BRCA cis rs10871290 1.000 rs11149710 chr16:74472546 G/T cg01733217 chr16:74700730 RFWD3 -0.49 -11.64 -0.42 1.55e-28 Breast cancer; BRCA cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.91 0.45 4.81e-34 Lung cancer in ever smokers; BRCA cis rs4285028 0.948 rs73855481 chr3:121676951 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs6459788 0.605 rs887628 chr7:157237589 G/A cg03453431 chr7:157225567 NA -0.45 -9.07 -0.34 1.41e-18 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg00990874 chr7:1149470 C7orf50 -0.49 -9.47 -0.35 5.36e-20 Bronchopulmonary dysplasia; BRCA cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg18876405 chr7:65276391 NA -0.51 -11.29 -0.41 4.34e-27 Aortic root size; BRCA cis rs11229555 0.574 rs72919749 chr11:58323467 T/C cg15696309 chr11:58395628 NA -0.5 -9.59 -0.35 2.01e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg05025164 chr4:1340916 KIAA1530 0.36 7.97 0.3 7.26e-15 Longevity; BRCA cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg24675658 chr1:53192096 ZYG11B -0.54 -12.27 -0.44 3.21e-31 Monocyte count; BRCA cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.22 7.87 0.3 1.49e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs9473147 0.602 rs9296567 chr6:47553402 G/A cg12968598 chr6:47444699 CD2AP 0.46 9.88 0.36 1.62e-21 Platelet distribution width;Mean platelet volume; BRCA trans rs61931739 0.517 rs10844738 chr12:34059503 T/A cg26384229 chr12:38710491 ALG10B 0.53 11.52 0.41 4.72e-28 Morning vs. evening chronotype; BRCA cis rs7809950 1.000 rs2237673 chr7:107131580 T/C cg23024343 chr7:107201750 COG5 -0.41 -9.64 -0.36 1.22e-20 Coronary artery disease; BRCA cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -8.19 -0.31 1.38e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3733585 0.648 rs7376155 chr4:9952588 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.36 -0.38 2.35e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.17 -0.31 1.66e-15 Aortic root size; BRCA trans rs6952808 0.656 rs12699646 chr7:2093162 T/G cg04565464 chr8:145669602 NFKBIL2 -0.37 -8.72 -0.33 2.36e-17 Bipolar disorder and schizophrenia; BRCA cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.68 -10.49 -0.38 7.35e-24 Schizophrenia; BRCA cis rs3768617 0.782 rs10752893 chr1:183046261 C/T ch.1.3577855R chr1:183094577 LAMC1 0.46 9.97 0.37 7.35e-22 Fuchs's corneal dystrophy; BRCA cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs2243480 0.803 rs13224048 chr7:65993766 G/A cg18252515 chr7:66147081 NA -1.06 -15.81 -0.53 9.02e-48 Diabetic kidney disease; BRCA cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.61 9.59 0.35 2.01e-20 Lung function (FEV1/FVC); BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -12.93 -0.46 3.78e-34 Bipolar disorder and schizophrenia; BRCA cis rs8038465 0.615 rs11637315 chr15:73944068 G/C cg15420318 chr15:73925796 NPTN 0.4 8.79 0.33 1.38e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9790314 0.747 rs7650703 chr3:160851639 T/C cg04691961 chr3:161091175 C3orf57 -0.46 -9.95 -0.37 8.93e-22 Morning vs. evening chronotype; BRCA cis rs4499344 0.693 rs8106502 chr19:33097796 C/T cg22980127 chr19:33182716 NUDT19 -0.38 -7.91 -0.3 1.11e-14 Mean platelet volume; BRCA cis rs6867032 0.958 rs4246754 chr5:2014776 A/C cg26168224 chr5:2018326 NA 0.6 15.13 0.51 2.08e-44 Gut microbiome composition (winter); BRCA cis rs6752107 0.837 rs3792108 chr2:234184952 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.39 0.41 1.73e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg08917208 chr2:24149416 ATAD2B 0.93 13.87 0.48 1.91e-38 Lymphocyte counts; BRCA cis rs3784262 0.528 rs4144005 chr15:58330094 C/T cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.43 -0.38 1.26e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs28374715 0.662 rs72737792 chr15:41515589 G/C cg18705301 chr15:41695430 NDUFAF1 -0.83 -17.2 -0.56 8.72e-55 Ulcerative colitis; BRCA cis rs78487399 0.908 rs75597324 chr2:43811239 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -7.89 -0.3 1.33e-14 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs10782582 0.609 rs72979226 chr1:76302222 C/A cg03433033 chr1:76189801 ACADM -0.4 -8.15 -0.31 1.91e-15 Daytime sleep phenotypes; BRCA cis rs2625529 0.652 rs28650442 chr15:72155445 A/T cg16672083 chr15:72433130 SENP8 -0.69 -16.56 -0.55 1.69e-51 Red blood cell count; BRCA cis rs4722404 0.592 rs13221367 chr7:3119823 C/T cg19214707 chr7:3157722 NA -0.37 -8.06 -0.3 3.75e-15 Atopic dermatitis; BRCA cis rs2302729 0.578 rs10848682 chr12:2771756 C/G cg19945202 chr12:2788847 CACNA1C -0.44 -9.79 -0.36 3.54e-21 Sleep quality; BRCA cis rs7131987 0.834 rs12228468 chr12:29453610 A/C cg09582351 chr12:29534625 ERGIC2 0.49 11.93 0.43 9.59e-30 QT interval; BRCA cis rs6835098 0.961 rs11737748 chr4:174130503 T/C cg27433088 chr4:174089019 GALNT7 -0.33 -8.15 -0.31 1.86e-15 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7918232 0.943 rs4747584 chr10:27373333 G/A cg14442939 chr10:27389572 ANKRD26 0.68 11.27 0.41 5.47e-27 Breast cancer; BRCA cis rs34779708 0.733 rs4007271 chr10:35546611 C/T cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs367943 1.000 rs348941 chr5:112824166 G/C cg12552261 chr5:112820674 MCC -0.57 -12.37 -0.44 1.18e-31 Type 2 diabetes; BRCA cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.99 14.76 0.5 1.17e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.95 0.48 8.51e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg05340658 chr4:99064831 C4orf37 0.65 15.98 0.53 1.27e-48 Colonoscopy-negative controls vs population controls; BRCA cis rs9818758 0.545 rs9853352 chr3:49813258 C/T cg00383909 chr3:49044727 WDR6 -0.71 -11.36 -0.41 2.22e-27 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs524281 0.861 rs3953856 chr11:65965908 T/A cg16950941 chr11:66035639 RAB1B -0.39 -8.06 -0.3 3.88e-15 Electroencephalogram traits; BRCA cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg13770153 chr20:60521292 NA -0.41 -9.1 -0.34 1.17e-18 Body mass index; BRCA cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.46e-23 Motion sickness; BRCA cis rs600806 0.850 rs1343465 chr1:109937426 T/C cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs78456975 0.739 rs13405352 chr2:1518726 C/T cg01028140 chr2:1542097 TPO -0.71 -14.29 -0.49 2.2e-40 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3008870 0.920 rs3008865 chr1:67402838 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.54 0.65 8.37e-78 Lymphocyte percentage of white cells; BRCA cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg05283184 chr6:79620031 NA -0.42 -10.83 -0.39 3.42e-25 Intelligence (multi-trait analysis); BRCA cis rs17092148 0.887 rs6120684 chr20:33179788 A/G cg16810054 chr20:33298113 TP53INP2 -0.47 -10.67 -0.39 1.38e-24 Neuroticism; BRCA cis rs2635047 1.000 rs2684841 chr18:44724262 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 8.27 0.31 7.97e-16 Educational attainment; BRCA cis rs7903847 0.642 rs7896100 chr10:99156994 C/T cg20016023 chr10:99160130 RRP12 -0.26 -8.47 -0.32 1.68e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs3770081 1.000 rs56104203 chr2:86336256 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.63 -8.62 -0.32 5.42e-17 Facial emotion recognition (sad faces); BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.81 -14.42 -0.5 5.27e-41 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs739401 0.967 rs451041 chr11:3060725 C/T cg25174290 chr11:3078921 CARS 0.37 11.25 0.41 6.29e-27 Longevity; BRCA cis rs895636 0.716 rs873745 chr2:45193173 C/G cg16198908 chr2:45192207 NA 0.44 8.6 0.32 6.23e-17 Metabolite levels;Fasting plasma glucose; BRCA cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.44 -9.58 -0.35 2.07e-20 Multiple sclerosis; BRCA cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg02503808 chr4:7069936 GRPEL1 -0.8 -14.52 -0.5 1.72e-41 Monocyte percentage of white cells; BRCA trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.81 -0.3 2.33e-14 Corneal astigmatism; BRCA cis rs274567 0.550 rs272885 chr5:131667736 A/G cg24060327 chr5:131705240 SLC22A5 -0.64 -12.53 -0.44 2.43e-32 Blood metabolite levels; BRCA cis rs9868809 0.881 rs57334642 chr3:48666795 C/T cg00383909 chr3:49044727 WDR6 0.54 8.08 0.3 3.27e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs17270561 0.666 rs4712976 chr6:25842203 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 10.87 0.39 2.35e-25 Iron status biomarkers; BRCA cis rs7592578 0.679 rs62181020 chr2:191325601 A/C cg10560079 chr2:191398806 TMEM194B -0.68 -12.78 -0.45 1.86e-33 Diastolic blood pressure; BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.32 0.68 1.65e-87 Platelet count; BRCA trans rs8073060 0.586 rs225291 chr17:33927126 A/G cg19694781 chr19:47549865 TMEM160 -0.81 -16.93 -0.56 2.26e-53 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs10751667 0.577 rs7946461 chr11:974035 A/G ch.11.42038R chr11:967971 AP2A2 0.52 16.57 0.55 1.53e-51 Alzheimer's disease (late onset); BRCA cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg11266682 chr4:10021025 SLC2A9 0.41 10.86 0.39 2.57e-25 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg23505145 chr19:12996616 KLF1 0.56 12.12 0.43 1.35e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs713587 0.521 rs35177510 chr2:25089594 C/A cg04586622 chr2:25135609 ADCY3 0.42 10.83 0.39 3.33e-25 Body mass index in non-asthmatics; BRCA trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.32 -9.01 -0.34 2.31e-18 Intelligence (multi-trait analysis); BRCA trans rs11165623 0.740 rs12126692 chr1:96889258 C/G cg10631902 chr5:14652156 NA 0.47 14.57 0.5 1.02e-41 Hip circumference;Waist circumference; BRCA cis rs7772486 0.840 rs854144 chr6:146360880 G/T cg23711669 chr6:146136114 FBXO30 -0.63 -12.41 -0.44 7.42e-32 Lobe attachment (rater-scored or self-reported); BRCA cis rs7582180 0.629 rs4850926 chr2:100954117 C/T cg14675211 chr2:100938903 LONRF2 0.51 11.53 0.41 4.71e-28 Intelligence (multi-trait analysis); BRCA cis rs11191270 0.554 rs10444022 chr10:104084889 A/G cg15320455 chr10:103880129 LDB1 0.73 10.72 0.39 9.39e-25 Intelligence (multi-trait analysis); BRCA trans rs10506458 0.834 rs17738403 chr12:63389200 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.2 -18.94 -0.6 8.26e-64 Hemostatic factors and hematological phenotypes; BRCA cis rs12579753 1.000 rs11519754 chr12:82209181 A/T cg07988820 chr12:82153109 PPFIA2 -0.66 -10.53 -0.38 4.99e-24 Resting heart rate; BRCA cis rs3809566 0.963 rs4775608 chr15:63331940 A/G cg12160578 chr15:63334699 TPM1 -0.41 -8.31 -0.31 5.66e-16 Platelet count; BRCA cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg18876405 chr7:65276391 NA 0.62 15.36 0.52 1.54e-45 Aortic root size; BRCA cis rs1865721 1.000 rs1865721 chr18:73192446 C/T cg26385618 chr18:73139727 C18orf62 -0.39 -8.98 -0.33 3.1e-18 Intelligence; BRCA cis rs11249608 0.548 rs7732719 chr5:178463054 A/G cg21905437 chr5:178450457 ZNF879 0.51 10.41 0.38 1.48e-23 Pubertal anthropometrics; BRCA cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg18479299 chr3:125709523 NA -0.56 -9.05 -0.34 1.75e-18 Blood pressure (smoking interaction); BRCA cis rs4077515 0.934 rs78428995 chr9:139281847 T/C cg14019695 chr9:139328340 INPP5E 0.31 7.86 0.3 1.6e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg03452623 chr4:187889614 NA -0.34 -11.62 -0.42 1.81e-28 Lobe attachment (rater-scored or self-reported); BRCA trans rs11976180 0.569 rs12703565 chr7:143754401 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.93 -13.93 -0.48 1.08e-38 Obesity-related traits; BRCA cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg18876405 chr7:65276391 NA -0.5 -10.94 -0.4 1.15e-25 Aortic root size; BRCA cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg13114125 chr14:105738426 BRF1 -0.49 -10.52 -0.38 5.82e-24 Mean platelet volume;Platelet distribution width; BRCA cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg04586622 chr2:25135609 ADCY3 0.46 11.58 0.42 2.64e-28 Body mass index; BRCA cis rs9790314 1.000 rs6441373 chr3:161026717 T/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.0 -0.48 4.87e-39 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg04944784 chr2:26401820 FAM59B -0.66 -11.24 -0.41 6.93e-27 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg27170947 chr2:26402098 FAM59B -0.81 -13.05 -0.46 1.1e-34 Gut microbiome composition (summer); BRCA cis rs3099143 1.000 rs7178759 chr15:77143513 A/G cg21673338 chr15:77095150 SCAPER 0.46 8.64 0.32 4.5e-17 Recalcitrant atopic dermatitis; BRCA cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg00339695 chr16:24857497 SLC5A11 -0.54 -11.49 -0.41 6.59e-28 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs881375 0.867 rs10818484 chr9:123661194 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.54 0.32 9.54e-17 Rheumatoid arthritis; BRCA cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg13010199 chr12:38710504 ALG10B 0.44 8.48 0.32 1.53e-16 Heart rate; BRCA cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg14844989 chr11:31128820 NA -0.45 -9.56 -0.35 2.44e-20 Red blood cell count; BRCA cis rs3784262 0.669 rs4646603 chr15:58290024 G/A cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.87 -0.36 1.75e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4363385 0.597 rs6679201 chr1:152976840 C/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.08 -0.34 1.31e-18 Inflammatory skin disease; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg04871131 chr7:94954202 PON1 -0.46 -9.91 -0.36 1.27e-21 Paraoxonase activity; BRCA cis rs60843830 1.000 rs3791220 chr2:227066 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.79 18.49 0.59 1.93e-61 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs586533 0.801 rs637387 chr11:99495489 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.03 0.3 4.8e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.49e-23 Motion sickness; BRCA cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg12826209 chr6:26865740 GUSBL1 0.59 10.31 0.38 3.81e-23 Intelligence (multi-trait analysis); BRCA cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg12386194 chr3:101231763 SENP7 0.6 12.41 0.44 7.93e-32 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg07636037 chr3:49044803 WDR6 0.98 28.9 0.75 4.43e-118 Parkinson's disease; BRCA cis rs12618769 0.570 rs17444095 chr2:99075817 C/G cg10123293 chr2:99228465 UNC50 0.4 7.95 0.3 8.23e-15 Bipolar disorder; BRCA cis rs4845875 0.626 rs6697244 chr1:11838848 G/T cg24844545 chr1:11908347 NPPA 0.32 8.09 0.3 2.93e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg17845761 chr1:175162550 KIAA0040 0.26 9.9 0.36 1.35e-21 Alcohol dependence; BRCA cis rs6714710 0.603 rs10432626 chr2:98561153 C/A cg26665480 chr2:98280029 ACTR1B 0.57 13.39 0.47 3.18e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs3772130 0.926 rs13072767 chr3:121504098 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.68 0.39 1.31e-24 Cognitive performance; BRCA cis rs208520 0.690 rs1885100 chr6:66871047 C/G cg07460842 chr6:66804631 NA -0.99 -19.46 -0.61 1.38e-66 Exhaled nitric oxide output; BRCA trans rs7647973 0.593 rs9870755 chr3:49809841 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -7.91 -0.3 1.14e-14 Menarche (age at onset); BRCA cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg17845761 chr1:175162550 KIAA0040 0.26 9.91 0.37 1.19e-21 Alcohol dependence; BRCA cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg18876405 chr7:65276391 NA 0.55 13.22 0.46 1.89e-35 Aortic root size; BRCA cis rs881375 0.678 rs1014530 chr9:123685092 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.07 0.4 3.42e-26 Rheumatoid arthritis; BRCA cis rs9814567 0.929 rs13088413 chr3:134309977 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.79 0.33 1.42e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg23625390 chr15:77176239 SCAPER 0.35 7.97 0.3 7.23e-15 Blood metabolite levels; BRCA cis rs17253792 0.822 rs75555677 chr14:56096429 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg26248373 chr2:1572462 NA -0.47 -9.1 -0.34 1.16e-18 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.09 0.62 5.99e-70 Platelet count; BRCA cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg19901468 chr14:105411992 AHNAK2 -0.48 -11.21 -0.41 9.51e-27 Rheumatoid arthritis; BRCA cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg08923669 chr16:420230 MRPL28 0.37 9.03 0.34 2.05e-18 Bone mineral density (spine);Bone mineral density; BRCA cis rs8062405 1.000 rs3088215 chr16:28853996 A/C cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.4e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg24642439 chr20:33292090 TP53INP2 0.51 11.35 0.41 2.46e-27 Glomerular filtration rate (creatinine); BRCA cis rs6570726 0.935 rs384453 chr6:145815145 G/C cg23711669 chr6:146136114 FBXO30 0.64 15.05 0.51 4.81e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs6479891 1.000 rs9415697 chr10:65135137 T/C cg14819942 chr15:35414228 NA 0.35 8.65 0.32 4.02e-17 Arthritis (juvenile idiopathic); BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg16606324 chr3:10149918 C3orf24 0.56 11.15 0.4 1.74e-26 Alzheimer's disease; BRCA trans rs3733585 0.699 rs6449179 chr4:9969117 G/A cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 9.34e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg24130564 chr14:104152367 KLC1 -0.34 -7.86 -0.3 1.63e-14 Body mass index; BRCA cis rs2115630 0.645 rs1107179 chr15:85198362 A/C cg11189052 chr15:85197271 WDR73 0.57 14.3 0.49 1.81e-40 P wave terminal force; BRCA cis rs10463316 0.894 rs7723016 chr5:150764828 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.4 -0.32 2.96e-16 Metabolite levels (Pyroglutamine); BRCA cis rs7631605 0.586 rs6550466 chr3:37305480 T/C cg15934958 chr3:37212084 LRRFIP2 0.38 8.1 0.31 2.84e-15 Cerebrospinal P-tau181p levels; BRCA cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg02079420 chr8:82753780 SNX16 -0.3 -8.22 -0.31 1.12e-15 Diastolic blood pressure; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA trans rs61931739 0.517 rs11052980 chr12:34036036 T/C cg26384229 chr12:38710491 ALG10B 0.5 11.1 0.4 2.64e-26 Morning vs. evening chronotype; BRCA cis rs3845702 0.736 rs6727890 chr2:180832675 T/C cg01881094 chr2:180872142 CWC22 -1.01 -18.23 -0.58 4.24e-60 Schizophrenia; BRCA cis rs4975709 0.610 rs6886669 chr5:1867830 T/C cg20790798 chr5:1857306 NA -0.38 -8.79 -0.33 1.38e-17 Cardiovascular disease risk factors; BRCA cis rs7267979 0.844 rs6107027 chr20:25288632 A/G cg08601574 chr20:25228251 PYGB 0.33 7.84 0.3 1.85e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4820539 1.000 rs885963 chr22:23460939 G/T cg14186256 chr22:23484241 RTDR1 0.76 22.93 0.67 2.18e-85 Bone mineral density; BRCA cis rs1865760 1.000 rs1865760 chr6:25916979 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 11.36 0.41 2.34e-27 Height; BRCA cis rs6866344 0.561 rs55974982 chr5:178141421 G/A cg03877680 chr5:178157825 ZNF354A 0.83 16.47 0.55 4.74e-51 Neutrophil percentage of white cells; BRCA cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg06212747 chr3:49208901 KLHDC8B 0.47 9.39 0.35 1e-19 Parkinson's disease; BRCA cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg08045932 chr20:61659980 NA 0.5 11.21 0.41 9.54e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.2 -0.43 6.36e-31 Personality dimensions; BRCA cis rs600231 0.665 rs1784859 chr11:65220749 A/G cg01292856 chr11:65242576 NA -0.31 -7.94 -0.3 8.93e-15 Bone mineral density; BRCA cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.38 -8.2 -0.31 1.28e-15 Osteoporosis; BRCA cis rs877282 0.733 rs11253342 chr10:765072 A/G cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA cis rs9649465 0.967 rs2286831 chr7:123303477 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.66e-16 Migraine; BRCA cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg22105103 chr4:187893119 NA 0.37 11.92 0.43 1.04e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.02 0.43 3.78e-30 Multiple sclerosis; BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26314531 chr2:26401878 FAM59B -0.78 -12.51 -0.44 2.79e-32 Gut microbiome composition (summer); BRCA cis rs4481887 0.893 rs10888347 chr1:248448566 T/C cg00666640 chr1:248458726 OR2T12 0.33 8.54 0.32 9.9e-17 Common traits (Other); BRCA cis rs875971 0.862 rs2088655 chr7:65795711 T/C cg18876405 chr7:65276391 NA -0.5 -11.2 -0.41 1.06e-26 Aortic root size; BRCA cis rs812925 0.515 rs1177308 chr2:61387254 C/G cg15711740 chr2:61764176 XPO1 -0.32 -7.98 -0.3 6.66e-15 Immature fraction of reticulocytes; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11905131 chr22:24372483 LOC391322 -0.53 -12.18 -0.43 7.97e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs6582630 0.519 rs8189623 chr12:38351436 G/A cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 9.43e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg06808227 chr14:105710500 BRF1 -0.8 -15.93 -0.53 2.39e-48 Mean platelet volume;Platelet distribution width; BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg22535103 chr8:58192502 C8orf71 0.47 8.22 0.31 1.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs7264396 0.709 rs2425073 chr20:34293699 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.4 8.48 0.32 1.61e-16 Total cholesterol levels; BRCA cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 26.42 0.72 1.58e-104 Chronic sinus infection; BRCA cis rs4566357 0.615 rs10174591 chr2:227913140 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.44 -0.35 6.61e-20 Coronary artery disease; BRCA cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg20607798 chr8:58055168 NA 0.47 8.09 0.3 2.96e-15 Developmental language disorder (linguistic errors); BRCA cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg09359103 chr1:154839909 KCNN3 -0.57 -14.8 -0.51 7.83e-43 Prostate cancer; BRCA cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs13217239 0.646 rs62401067 chr6:27018101 T/A cg12292205 chr6:26970375 C6orf41 0.56 12.36 0.44 1.23e-31 Schizophrenia; BRCA trans rs877282 0.842 rs35872126 chr10:764545 G/A cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs807669 0.548 rs9605957 chr22:19187375 G/A cg02655711 chr22:19163373 SLC25A1 0.54 12.91 0.45 4.97e-34 Metabolite levels; BRCA cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7412746 0.658 rs4970986 chr1:150907955 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.24e-14 Melanoma; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg08470875 chr2:26401718 FAM59B 0.59 7.9 0.3 1.22e-14 Gut microbiome composition (summer); BRCA cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.04e-15 Alzheimer's disease (late onset); BRCA cis rs7011049 1.000 rs113124539 chr8:53854321 G/A cg26025543 chr8:53854495 NA 0.54 9.41 0.35 8.91e-20 Systolic blood pressure; BRCA cis rs13046373 0.535 rs9636840 chr21:32029979 A/G cg16431978 chr21:31797932 KRTAP13-3 -0.32 -8.03 -0.3 4.74e-15 HDL cholesterol; BRCA cis rs72615157 0.595 rs112241539 chr7:99847237 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.68 11.24 0.41 7.45e-27 Lung function (FEV1/FVC); BRCA cis rs7605378 0.964 rs2689763 chr2:200689555 G/A cg23649088 chr2:200775458 C2orf69 0.49 10.1 0.37 2.45e-22 Osteoporosis; BRCA cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg15485101 chr11:133734466 NA -0.39 -10.87 -0.39 2.32e-25 Childhood ear infection; BRCA cis rs4742903 0.904 rs10991167 chr9:106974382 C/T cg21169611 chr9:106856078 SMC2 -0.32 -8.4 -0.32 2.98e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs796364 1.000 rs281760 chr2:200787804 A/G cg23649088 chr2:200775458 C2orf69 0.59 8.81 0.33 1.18e-17 Schizophrenia; BRCA cis rs6142102 0.625 rs1883706 chr20:32552877 G/A cg24642439 chr20:33292090 TP53INP2 0.39 7.82 0.3 2.17e-14 Skin pigmentation; BRCA cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg08859206 chr1:53392774 SCP2 0.48 10.79 0.39 4.83e-25 Monocyte count; BRCA cis rs6835174 1.000 rs6835174 chr4:5976104 C/T cg08509927 chr4:5976063 C4orf50 -0.55 -9.41 -0.35 8.6e-20 Cannabis use (initiation); BRCA cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg15839431 chr19:19639596 YJEFN3 -0.39 -8.51 -0.32 1.22e-16 Bipolar disorder; BRCA cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11644478 chr21:40555479 PSMG1 0.71 13.92 0.48 1.11e-38 Cognitive function; BRCA cis rs7809950 0.954 rs62482543 chr7:107080656 G/A cg23024343 chr7:107201750 COG5 -0.44 -10.09 -0.37 2.64e-22 Coronary artery disease; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg21280719 chr6:42927975 GNMT -0.32 -13.75 -0.48 7.35e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg04166393 chr7:2884313 GNA12 0.48 9.04 0.34 1.82e-18 Height; BRCA cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg18876405 chr7:65276391 NA 0.5 11.04 0.4 4.57e-26 Aortic root size; BRCA cis rs709400 0.663 rs11628969 chr14:103940911 G/A cg26031613 chr14:104095156 KLC1 0.75 16.33 0.54 2.24e-50 Body mass index; BRCA cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg04553112 chr3:125709451 NA -0.55 -8.29 -0.31 6.59e-16 Blood pressure (smoking interaction); BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg22907277 chr7:1156413 C7orf50 0.59 9.17 0.34 6.51e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg20203395 chr5:56204925 C5orf35 -0.49 -10.25 -0.38 6.14e-23 Initial pursuit acceleration; BRCA cis rs3849570 1.000 rs6548773 chr3:81840222 C/T cg07356753 chr3:81810745 GBE1 0.47 11.38 0.41 1.92e-27 Waist circumference;Body mass index; BRCA cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA trans rs7824557 0.569 rs35418978 chr8:11186453 T/C cg06636001 chr8:8085503 FLJ10661 0.5 10.68 0.39 1.27e-24 Retinal vascular caliber; BRCA cis rs6005807 0.719 rs12165893 chr22:29033545 T/C cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg24531977 chr5:56204891 C5orf35 -0.55 -11.34 -0.41 2.7e-27 Coronary artery disease; BRCA cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg27286337 chr10:134555280 INPP5A 0.6 10.15 0.37 1.51e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg07636037 chr3:49044803 WDR6 0.42 8.51 0.32 1.22e-16 Resting heart rate; BRCA trans rs1973993 0.544 rs2800427 chr1:97002766 A/C cg10631902 chr5:14652156 NA 0.48 14.84 0.51 5.25e-43 Weight; BRCA trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg22491629 chr6:157744540 C6orf35 -0.67 -12.44 -0.44 5.53e-32 Hemostatic factors and hematological phenotypes; BRCA cis rs10744422 1.000 rs7139055 chr12:123364198 A/G cg25930673 chr12:123319894 HIP1R 0.52 7.92 0.3 1.08e-14 Schizophrenia; BRCA cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg21475434 chr5:93447410 FAM172A 0.67 8.44 0.32 2.09e-16 Diabetic retinopathy; BRCA cis rs4787491 0.729 rs3814878 chr16:30041966 A/G cg06326092 chr16:30034487 C16orf92 0.35 8.65 0.32 4.13e-17 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs9929218 0.520 rs1078621 chr16:68778996 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.89 21.69 0.65 1.39e-78 Colorectal cancer; BRCA cis rs2387326 0.672 rs10829347 chr10:129947386 T/C cg16087940 chr10:129947807 NA -0.45 -7.94 -0.3 9.32e-15 Select biomarker traits; BRCA cis rs36051895 0.632 rs10974979 chr9:5131731 C/A cg02405213 chr9:5042618 JAK2 -0.48 -8.64 -0.32 4.37e-17 Pediatric autoimmune diseases; BRCA cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg08917208 chr2:24149416 ATAD2B 0.89 12.44 0.44 5.85e-32 Lymphocyte counts; BRCA cis rs11112613 0.762 rs17037308 chr12:105949847 T/G cg03607813 chr12:105948248 NA 0.6 11.21 0.41 9.41e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs829883 0.966 rs249853 chr12:98864908 A/C cg25150519 chr12:98850993 NA 0.45 8.6 0.32 6.18e-17 Colorectal adenoma (advanced); BRCA cis rs7255436 0.965 rs7249624 chr19:8446135 G/A cg10811474 chr19:8428787 ANGPTL4 -0.32 -8.05 -0.3 4.15e-15 HDL cholesterol; BRCA cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg06494592 chr3:125709126 NA -0.54 -8.5 -0.32 1.33e-16 Blood pressure (smoking interaction); BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.59 12.25 0.44 4.02e-31 Lymphocyte counts; BRCA cis rs2304069 0.826 rs2244195 chr5:149403528 C/A cg10852222 chr5:149380144 HMGXB3;TIGD6 0.47 8.07 0.3 3.44e-15 HIV-1 control; BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg14004847 chr7:1930337 MAD1L1 -0.41 -8.23 -0.31 1.07e-15 Bipolar disorder and schizophrenia; BRCA cis rs4713118 0.586 rs6905522 chr6:28086479 A/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Parkinson's disease; BRCA cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg01939980 chr4:1354348 KIAA1530 0.38 10.72 0.39 9.05e-25 Longevity; BRCA cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg05340658 chr4:99064831 C4orf37 0.59 11.9 0.43 1.29e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.877 rs9314099 chr5:93447375 T/C cg25358565 chr5:93447407 FAM172A 1.18 19.96 0.62 2.78e-69 Diabetic retinopathy; BRCA cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs9381040 0.674 rs4711657 chr6:41162715 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -7.97 -0.3 7.48e-15 Alzheimer's disease (late onset); BRCA cis rs7264396 0.623 rs2425123 chr20:34329547 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.13 -0.43 1.33e-30 Total cholesterol levels; BRCA trans rs6952808 0.624 rs60137119 chr7:2083664 A/G cg04565464 chr8:145669602 NFKBIL2 0.42 9.51 0.35 3.7e-20 Bipolar disorder and schizophrenia; BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26314531 chr2:26401878 FAM59B -0.95 -16.58 -0.55 1.33e-51 Gut microbiome composition (summer); BRCA cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg07606381 chr6:8435919 SLC35B3 0.63 13.66 0.48 1.79e-37 Motion sickness; BRCA cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg10523679 chr1:76189770 ACADM 0.75 15.74 0.53 2.06e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.38 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs265548 0.646 rs36692 chr19:17906839 C/T cg04517722 chr19:17905589 B3GNT3 0.42 8.17 0.31 1.71e-15 Tumor biomarkers; BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg22920501 chr2:26401640 FAM59B -0.63 -11.27 -0.41 5.37e-27 Gut microbiome composition (summer); BRCA cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg11598736 chr3:195384522 SDHAP2 0.58 10.42 0.38 1.33e-23 Lung disease severity in cystic fibrosis; BRCA cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg05890377 chr2:74357713 NA 0.47 11.72 0.42 7.25e-29 Gestational age at birth (maternal effect); BRCA cis rs172166 0.694 rs203892 chr6:28067196 T/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.38 0.31 3.4e-16 Cardiac Troponin-T levels; BRCA cis rs7666738 0.576 rs7660951 chr4:98651581 T/A cg05340658 chr4:99064831 C4orf37 0.56 10.98 0.4 8.17e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg05283184 chr6:79620031 NA -0.39 -9.9 -0.36 1.35e-21 Intelligence (multi-trait analysis); BRCA cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg11366901 chr6:160182831 ACAT2 0.78 15.21 0.52 8.47e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.3 -0.38 4.09e-23 Psoriasis; BRCA cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg27211696 chr2:191398769 TMEM194B 0.53 11.9 0.43 1.28e-29 Pulse pressure; BRCA cis rs514406 0.708 rs536621 chr1:53309097 A/G cg16325326 chr1:53192061 ZYG11B 0.57 12.77 0.45 2.08e-33 Monocyte count; BRCA cis rs28374715 0.681 rs7163989 chr15:41614621 A/G cg18705301 chr15:41695430 NDUFAF1 -0.81 -18.94 -0.6 7.61e-64 Ulcerative colitis; BRCA cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg10621924 chr7:39171070 POU6F2 0.41 8.48 0.32 1.61e-16 IgG glycosylation; BRCA cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg12573674 chr2:1569213 NA -0.55 -11.95 -0.43 7.83e-30 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs344364 0.511 rs1742467 chr16:1950187 G/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -9.78 -0.36 3.77e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs116095464 0.558 rs10065239 chr5:275288 C/T cg22496380 chr5:211416 CCDC127 -1.0 -14.19 -0.49 6.2e-40 Breast cancer; BRCA cis rs936229 0.768 rs12442901 chr15:75083912 A/G cg14664628 chr15:75095509 CSK -0.93 -27.01 -0.73 9.35e-108 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6964587 0.626 rs10234074 chr7:91520119 C/T cg17063962 chr7:91808500 NA -0.55 -12.75 -0.45 2.49e-33 Breast cancer; BRCA cis rs10927875 0.615 rs10927886 chr1:16339313 C/G cg22431228 chr1:16359049 CLCNKA 0.4 8.97 0.33 3.28e-18 Dilated cardiomyopathy; BRCA cis rs9486715 0.867 rs9373833 chr6:96904998 A/G cg06623918 chr6:96969491 KIAA0776 -0.91 -25.51 -0.71 1.54e-99 Headache; BRCA cis rs17376456 1.000 rs34068652 chr5:93563319 G/A cg21475434 chr5:93447410 FAM172A 0.68 8.72 0.33 2.43e-17 Diabetic retinopathy; BRCA trans rs6479891 0.915 rs7896677 chr10:65065305 T/G cg14819942 chr15:35414228 NA -0.35 -8.56 -0.32 8.37e-17 Arthritis (juvenile idiopathic); BRCA cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg18446336 chr7:2847575 GNA12 -0.41 -10.3 -0.38 4.01e-23 Height; BRCA cis rs7474896 0.537 rs2472149 chr10:38262196 A/C cg25427524 chr10:38739819 LOC399744 0.55 10.07 0.37 3.12e-22 Obesity (extreme); BRCA cis rs812925 0.511 rs11886950 chr2:61399317 A/C cg15711740 chr2:61764176 XPO1 -0.33 -8.16 -0.31 1.77e-15 Immature fraction of reticulocytes; BRCA cis rs887829 0.570 rs4553819 chr2:234594083 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.38 -0.31 3.32e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs58235267 0.656 rs12713469 chr2:63059927 C/T cg17519650 chr2:63277830 OTX1 -0.43 -9.4 -0.35 9.93e-20 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.74 -0.55 1.93e-52 Axial length; BRCA cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs250677 0.522 rs998304 chr5:148382365 C/A cg12140854 chr5:148520817 ABLIM3 -0.41 -8.36 -0.31 3.82e-16 Breast cancer; BRCA cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg14983838 chr19:29218262 NA 0.59 11.86 0.42 1.8e-29 Methadone dose in opioid dependence; BRCA cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -8.26 -0.31 8.65e-16 Schizophrenia; BRCA cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg00677455 chr12:58241039 CTDSP2 0.6 13.43 0.47 2.03e-36 Multiple sclerosis; BRCA cis rs6665290 0.566 rs1513617 chr1:227447213 C/T cg10327440 chr1:227177885 CDC42BPA 0.84 18.09 0.58 2.29e-59 Myeloid white cell count; BRCA cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg08999081 chr20:33150536 PIGU 0.38 10.06 0.37 3.31e-22 Coronary artery disease; BRCA cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg11952622 chr19:58962976 ZNF324B 0.7 15.17 0.51 1.27e-44 Mean platelet volume; BRCA cis rs1580019 0.961 rs4357201 chr7:32496333 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.48 0.32 1.51e-16 Cognitive ability; BRCA cis rs1707322 0.721 rs11211165 chr1:46157906 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3768617 0.754 rs6673768 chr1:182983396 G/T ch.1.3577855R chr1:183094577 LAMC1 0.45 9.8 0.36 3.28e-21 Fuchs's corneal dystrophy; BRCA trans rs11098499 0.697 rs28458294 chr4:120238924 T/C cg25214090 chr10:38739885 LOC399744 0.46 10.61 0.39 2.52e-24 Corneal astigmatism; BRCA cis rs7119038 0.818 rs7942535 chr11:118681464 C/T cg19308663 chr11:118741387 NA -0.37 -9.02 -0.34 2.1e-18 Sjögren's syndrome; BRCA cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.11 0.4 2.44e-26 Bipolar disorder; BRCA cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg20090143 chr19:45452003 APOC2 0.27 8.11 0.31 2.59e-15 Blood protein levels; BRCA cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg12927641 chr6:109611667 NA -0.42 -10.89 -0.4 1.93e-25 Reticulocyte fraction of red cells; BRCA cis rs4566357 0.576 rs6750845 chr2:227911037 T/G cg11843606 chr2:227700838 RHBDD1 -0.42 -9.48 -0.35 4.75e-20 Coronary artery disease; BRCA cis rs765787 0.530 rs55920042 chr15:45541577 G/A cg15395560 chr15:45543142 SLC28A2 0.29 8.07 0.3 3.4e-15 Uric acid levels; BRCA cis rs11098499 0.863 rs6858777 chr4:120475966 A/G cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs17270561 0.609 rs4712957 chr6:25719814 C/T cg16482183 chr6:26056742 HIST1H1C 0.43 8.46 0.32 1.89e-16 Iron status biomarkers; BRCA cis rs1059312 0.966 rs7135968 chr12:129280066 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.24 0.34 3.68e-19 Systemic lupus erythematosus; BRCA cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA trans rs2204008 0.660 rs2320745 chr12:38239101 T/C cg06521331 chr12:34319734 NA -0.53 -10.04 -0.37 4.03e-22 Bladder cancer; BRCA trans rs9858542 0.953 rs9814873 chr3:49454112 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.07 -0.34 1.44e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs4650994 0.507 rs2811312 chr1:178617603 A/G cg05059571 chr16:84539110 KIAA1609 0.54 11.95 0.43 7.58e-30 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.49 -0.32 1.45e-16 Bipolar disorder; BRCA trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg25214090 chr10:38739885 LOC399744 0.54 12.25 0.44 3.83e-31 Corneal astigmatism; BRCA cis rs7607369 0.559 rs4674340 chr2:219659799 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -10.42 -0.38 1.35e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg18876405 chr7:65276391 NA 0.51 11.55 0.42 3.6e-28 Aortic root size; BRCA cis rs875971 0.862 rs709609 chr7:65560561 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.97 -0.3 7.18e-15 Aortic root size; BRCA cis rs11605924 0.967 rs6485646 chr11:45865764 G/A ch.11.939596F chr11:45881766 CRY2 -0.46 -10.16 -0.37 1.38e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4665809 1.000 rs11126340 chr2:26253255 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.66 -12.32 -0.44 1.96e-31 Gut microbiome composition (summer); BRCA cis rs9393777 0.513 rs61240102 chr6:27124904 G/C cg12292205 chr6:26970375 C6orf41 -0.65 -10.23 -0.38 7.54e-23 Intelligence (multi-trait analysis); BRCA trans rs7647973 0.710 rs12637313 chr3:49645458 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.4 -0.32 2.91e-16 Menarche (age at onset); BRCA cis rs7555523 0.887 rs4657477 chr1:165736175 C/T cg24409356 chr1:165738333 TMCO1 0.49 8.76 0.33 1.8e-17 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs3845702 0.866 rs818659 chr2:180870893 G/A cg01881094 chr2:180872142 CWC22 0.66 13.28 0.47 9.88e-36 Schizophrenia; BRCA cis rs7267979 1.000 rs2500448 chr20:25404027 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.18 -0.31 1.49e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.11 -0.46 5.75e-35 Platelet count; BRCA cis rs2239547 0.522 rs6771610 chr3:53026104 T/C cg11645453 chr3:52864694 ITIH4 0.41 9.95 0.37 9.1e-22 Schizophrenia; BRCA cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.42 -0.32 2.53e-16 Aortic root size; BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg00802000 chr16:706648 WDR90 -0.39 -9.18 -0.34 5.85e-19 Height; BRCA cis rs11098499 0.566 rs17051356 chr4:120585308 C/T cg09307838 chr4:120376055 NA 0.57 10.62 0.39 2.16e-24 Corneal astigmatism; BRCA cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08109568 chr15:31115862 NA 0.41 10.11 0.37 2.16e-22 Huntington's disease progression; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg15790184 chr11:494944 RNH1 0.64 9.62 0.36 1.54e-20 Body mass index; BRCA cis rs7617773 0.707 rs13061269 chr3:48373343 C/T cg11946769 chr3:48343235 NME6 0.67 13.39 0.47 3.13e-36 Coronary artery disease; BRCA cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg10820045 chr2:198174542 NA -0.41 -9.36 -0.35 1.29e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2072438 0.503 rs1323474 chr9:123852859 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.26 0.31 8.23e-16 Rheumatoid arthritis; BRCA cis rs3784262 0.904 rs4646620 chr15:58258241 G/A cg12031962 chr15:58353849 ALDH1A2 -0.43 -11.82 -0.42 2.59e-29 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2882667 0.964 rs11958050 chr5:138301828 A/G cg04439458 chr5:138467593 SIL1 -0.29 -8.1 -0.31 2.72e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg18904891 chr8:8559673 CLDN23 0.65 12.69 0.45 4.54e-33 Obesity-related traits; BRCA cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg20476274 chr7:133979776 SLC35B4 0.7 21.42 0.65 4.15e-77 Mean platelet volume; BRCA trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg15934090 chr1:100435551 SLC35A3 0.35 7.92 0.3 1.09e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs11711311 0.826 rs13077644 chr3:113467777 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.28 0.34 2.7e-19 IgG glycosylation; BRCA cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.4 -0.32 2.81e-16 IgG glycosylation; BRCA cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg24130564 chr14:104152367 KLC1 -0.38 -9.09 -0.34 1.19e-18 Body mass index; BRCA cis rs8180040 0.934 rs62260710 chr3:47564462 C/G cg16586182 chr3:47516702 SCAP 0.63 13.66 0.48 1.8e-37 Colorectal cancer; BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg21782813 chr7:2030301 MAD1L1 0.34 9.07 0.34 1.46e-18 Bipolar disorder and schizophrenia; BRCA cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs113835537 0.529 rs57724777 chr11:66236431 G/A cg24851651 chr11:66362959 CCS 0.51 8.76 0.33 1.71e-17 Airway imaging phenotypes; BRCA cis rs3767633 0.858 rs7532448 chr1:161862745 C/T cg09175582 chr1:161736000 ATF6 0.53 8.75 0.33 1.93e-17 IgG glycosylation; BRCA cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg14061069 chr19:46274453 DMPK -0.48 -11.95 -0.43 7.69e-30 Coronary artery disease; BRCA cis rs10751667 0.621 rs7396049 chr11:1001561 G/A cg01483505 chr11:975446 AP2A2 0.34 9.19 0.34 5.61e-19 Alzheimer's disease (late onset); BRCA cis rs2882667 0.898 rs4380651 chr5:138391072 A/G cg04439458 chr5:138467593 SIL1 -0.31 -8.36 -0.31 3.79e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.67 -0.32 3.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg03264133 chr6:25882463 NA -0.41 -9.19 -0.34 5.63e-19 Height; BRCA cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg24829409 chr8:58192753 C8orf71 -0.44 -8.51 -0.32 1.28e-16 Developmental language disorder (linguistic errors); BRCA cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.88 -0.36 1.6e-21 Alzheimer's disease (late onset); BRCA cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg20891283 chr12:69753455 YEATS4 0.73 21.96 0.66 4.86e-80 Blood protein levels; BRCA trans rs2204008 0.807 rs12816136 chr12:38456037 A/G cg06521331 chr12:34319734 NA 0.46 9.15 0.34 7.82e-19 Bladder cancer; BRCA cis rs9527 0.567 rs11191573 chr10:104896816 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg13319975 chr6:146136371 FBXO30 0.34 8.04 0.3 4.24e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.45 9.98 0.37 7.02e-22 Alzheimer's disease (late onset); BRCA cis rs1003719 0.667 rs6517404 chr21:38494918 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.57 13.35 0.47 4.87e-36 Eye color traits; BRCA cis rs8062405 0.964 rs78613234 chr16:28839425 T/C cg16576597 chr16:28551801 NUPR1 0.29 8.27 0.31 7.65e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4713118 0.662 rs9468275 chr6:28026136 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs1878931 0.580 rs8062722 chr16:3409161 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.82 20.2 0.62 1.55e-70 Body mass index (adult); BRCA cis rs6835174 1.000 rs16837971 chr4:5977133 G/T cg08509927 chr4:5976063 C4orf50 0.51 8.83 0.33 9.7e-18 Cannabis use (initiation); BRCA cis rs7766436 0.885 rs12524244 chr6:22585287 T/C cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA cis rs9309473 1.000 rs7598396 chr2:73652628 A/G cg20560298 chr2:73613845 ALMS1 -0.44 -10.97 -0.4 8.59e-26 Metabolite levels; BRCA cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -18.15 -0.58 1.17e-59 Extrinsic epigenetic age acceleration; BRCA cis rs6500602 0.893 rs934888 chr16:4462832 C/T cg08645402 chr16:4508243 NA 0.4 8.8 0.33 1.32e-17 Schizophrenia; BRCA cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg12935359 chr14:103987150 CKB -0.59 -14.06 -0.49 2.51e-39 Body mass index; BRCA cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.69 0.32 3.12e-17 Personality dimensions; BRCA cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg18578876 chr12:123200353 GPR109B -0.53 -8.26 -0.31 8.3e-16 Body mass index; BRCA cis rs10504073 0.669 rs818558 chr8:50030855 A/G cg00325661 chr8:49890786 NA 0.38 10.87 0.39 2.38e-25 Blood metabolite ratios; BRCA cis rs2354432 0.607 rs66486822 chr1:146802653 T/A cg25205988 chr1:146714368 CHD1L -0.91 -13.1 -0.46 6.75e-35 Mitochondrial DNA levels; BRCA cis rs849141 0.961 rs506154 chr7:28202079 T/C cg22892036 chr7:28189139 JAZF1 0.46 8.28 0.31 7.17e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg25358565 chr5:93447407 FAM172A 1.19 18.3 0.59 1.86e-60 Diabetic retinopathy; BRCA cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg18305652 chr10:134549665 INPP5A 0.5 11.37 0.41 2.14e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9914988 0.725 rs9905510 chr17:27092325 G/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.82 -0.33 1.08e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7914558 0.901 rs35525740 chr10:104941112 A/T cg04362960 chr10:104952993 NT5C2 0.42 10.19 0.37 1.04e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg06064525 chr11:970664 AP2A2 -0.48 -16.04 -0.54 6.73e-49 Alzheimer's disease (late onset); BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg15242686 chr22:24348715 GSTTP1 -0.48 -12.18 -0.43 8.1e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.19 -0.31 1.47e-15 Total body bone mineral density; BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg11062466 chr8:58055876 NA 0.51 8.95 0.33 3.73e-18 Developmental language disorder (linguistic errors); BRCA cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.58e-17 Hip circumference adjusted for BMI; BRCA cis rs1712517 0.838 rs6584543 chr10:104997014 G/A cg05636881 chr10:105038444 INA -0.4 -9.22 -0.34 4.3e-19 Migraine; BRCA cis rs61931739 0.500 rs11524949 chr12:34435551 C/T cg06521331 chr12:34319734 NA -0.56 -9.8 -0.36 3.17e-21 Morning vs. evening chronotype; BRCA cis rs7829975 0.502 rs7820738 chr8:8702607 C/G cg15556689 chr8:8085844 FLJ10661 -0.38 -10.75 -0.39 7.18e-25 Mood instability; BRCA cis rs6964587 1.000 rs7455444 chr7:91639313 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.13 0.31 2.24e-15 Breast cancer; BRCA cis rs6582630 0.502 rs7311700 chr12:38463232 T/A cg26384229 chr12:38710491 ALG10B 0.77 17.59 0.57 8.61e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg05025164 chr4:1340916 KIAA1530 0.64 12.84 0.45 9.4e-34 Longevity; BRCA cis rs701145 0.643 rs453699 chr3:153924784 A/G cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs113835537 0.529 rs7943327 chr11:66256581 G/C cg24851651 chr11:66362959 CCS 0.44 8.34 0.31 4.58e-16 Airway imaging phenotypes; BRCA cis rs243505 0.898 rs243539 chr7:148403917 T/C cg09806900 chr7:148480153 CUL1 -0.4 -8.38 -0.31 3.31e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13136331 0.721 rs2627721 chr4:88683429 G/A cg22416721 chr4:88570574 DMP1 -0.52 -12.29 -0.44 2.52e-31 Sitting height ratio; BRCA trans rs11098499 0.754 rs938056 chr4:120237453 C/T cg25214090 chr10:38739885 LOC399744 0.46 10.45 0.38 1.05e-23 Corneal astigmatism; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg10819733 chr22:24237672 NA -0.31 -8.74 -0.33 2.07e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg04944784 chr2:26401820 FAM59B -0.85 -13.19 -0.46 2.64e-35 Gut microbiome composition (summer); BRCA cis rs61931739 0.534 rs2220547 chr12:34106255 G/A cg06521331 chr12:34319734 NA -0.63 -11.57 -0.42 3.12e-28 Morning vs. evening chronotype; BRCA cis rs7249921 0.802 rs62111399 chr19:35668771 C/T cg15419183 chr19:35660584 FXYD5 0.46 10.41 0.38 1.46e-23 Platelet count; BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg21724239 chr8:58056113 NA 0.56 9.11 0.34 1.02e-18 Developmental language disorder (linguistic errors); BRCA cis rs208520 0.690 rs2797693 chr6:66868985 T/C cg07460842 chr6:66804631 NA -0.99 -19.46 -0.61 1.38e-66 Exhaled nitric oxide output; BRCA cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg24642439 chr20:33292090 TP53INP2 0.49 11.03 0.4 4.97e-26 Glomerular filtration rate (creatinine); BRCA cis rs11758351 1.000 rs3757135 chr6:26200707 G/A cg01420254 chr6:26195488 NA 0.58 8.99 0.34 2.78e-18 Gout;Renal underexcretion gout; BRCA cis rs7615952 1.000 rs7616044 chr3:125649354 G/C cg05084668 chr3:125655381 ALG1L -0.73 -12.97 -0.46 2.52e-34 Blood pressure (smoking interaction); BRCA cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg00409905 chr10:38381863 ZNF37A 0.49 9.85 0.36 2.05e-21 Extrinsic epigenetic age acceleration; BRCA cis rs208520 1.000 rs72882100 chr6:66981495 G/C cg07460842 chr6:66804631 NA 0.89 14.32 0.49 1.58e-40 Exhaled nitric oxide output; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg09177884 chr7:1199841 ZFAND2A -0.42 -8.72 -0.33 2.4e-17 Longevity;Endometriosis; BRCA cis rs4631830 0.720 rs2611471 chr10:51503559 G/C cg20129853 chr10:51489980 NA -0.32 -8.4 -0.32 2.99e-16 Prostate-specific antigen levels; BRCA cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg17507749 chr15:85114479 UBE2QP1 0.55 10.42 0.38 1.34e-23 Schizophrenia; BRCA cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg05890377 chr2:74357713 NA 0.48 11.55 0.42 3.63e-28 Gestational age at birth (maternal effect); BRCA cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg06212747 chr3:49208901 KLHDC8B 0.52 10.89 0.4 1.81e-25 Parkinson's disease; BRCA cis rs11098499 0.754 rs17049949 chr4:120255290 A/G cg09307838 chr4:120376055 NA 0.63 13.65 0.48 2.17e-37 Corneal astigmatism; BRCA cis rs3733585 0.683 rs6449140 chr4:9936437 G/C cg11266682 chr4:10021025 SLC2A9 -0.42 -11.02 -0.4 5.48e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7520050 0.966 rs11589562 chr1:46466721 C/T cg24296786 chr1:45957014 TESK2 -0.45 -9.62 -0.36 1.47e-20 Red blood cell count;Reticulocyte count; BRCA cis rs514406 0.679 rs541852 chr1:53256834 A/G cg27535305 chr1:53392650 SCP2 0.49 11.38 0.41 1.82e-27 Monocyte count; BRCA cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.87 18.59 0.59 5.39e-62 Smoking behavior; BRCA trans rs6479891 1.000 rs4133250 chr10:65092405 G/A cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs9463078 0.683 rs12215252 chr6:44736265 C/T cg25276700 chr6:44698697 NA 0.37 8.04 0.3 4.37e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.91 -0.33 5.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7267979 1.000 rs397119 chr20:25440187 C/A cg08601574 chr20:25228251 PYGB 0.33 8.05 0.3 4.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA trans rs9650657 0.537 rs7016385 chr8:10779472 A/G cg06636001 chr8:8085503 FLJ10661 0.51 10.62 0.39 2.28e-24 Neuroticism; BRCA cis rs36051895 0.559 rs7868706 chr9:5210936 T/G cg02405213 chr9:5042618 JAK2 -0.45 -8.66 -0.32 3.94e-17 Pediatric autoimmune diseases; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg22963979 chr7:1858916 MAD1L1 -0.38 -8.17 -0.31 1.61e-15 Bipolar disorder and schizophrenia; BRCA trans rs7647973 0.593 rs58339610 chr3:49845006 T/A cg21659725 chr3:3221576 CRBN 0.47 8.62 0.32 5.23e-17 Menarche (age at onset); BRCA trans rs2204008 0.591 rs11495396 chr12:38380182 C/T cg06521331 chr12:34319734 NA -0.45 -8.33 -0.31 4.76e-16 Bladder cancer; BRCA cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg14008862 chr17:28927542 LRRC37B2 0.57 8.09 0.3 2.93e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs4714291 0.802 rs2983143 chr6:40044850 G/T cg02267698 chr19:7991119 CTXN1 -0.44 -8.89 -0.33 6.16e-18 Strep throat; BRCA cis rs523522 0.962 rs4767903 chr12:120930046 G/A cg12219531 chr12:120966889 COQ5 0.52 11.28 0.41 4.97e-27 High light scatter reticulocyte count; BRCA cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg08601574 chr20:25228251 PYGB 0.4 9.23 0.34 3.88e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg06145435 chr7:1022769 CYP2W1 0.42 8.31 0.31 5.79e-16 Bronchopulmonary dysplasia; BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.19 0.43 7.2e-31 Platelet count; BRCA cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg07395648 chr5:131743802 NA -0.36 -8.7 -0.33 2.86e-17 Blood metabolite levels; BRCA trans rs60843830 0.964 rs7584915 chr2:264227 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 13.83 0.48 3e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6580649 0.943 rs9651993 chr12:48404692 G/A cg24011408 chr12:48396354 COL2A1 0.56 9.31 0.35 1.95e-19 Lung cancer; BRCA cis rs11583043 0.918 rs11582211 chr1:101416871 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.34 0.35 1.52e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs34779708 0.750 rs35032841 chr10:35312687 G/A cg03585969 chr10:35415529 CREM 0.49 10.25 0.38 6.46e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs7493 0.853 rs11770901 chr7:95054480 T/C cg17330251 chr7:94953956 PON1 -0.42 -8.48 -0.32 1.52e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6546550 0.933 rs57278310 chr2:70093647 T/C cg02498382 chr2:70120550 SNRNP27 -0.43 -9.27 -0.34 2.74e-19 Prevalent atrial fibrillation; BRCA cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg09184832 chr6:79620586 NA -0.41 -8.16 -0.31 1.82e-15 Intelligence (multi-trait analysis); BRCA cis rs929596 0.785 rs34352510 chr2:234650562 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.48 -12.13 -0.43 1.22e-30 Total bilirubin levels in HIV-1 infection; BRCA cis rs2286885 1.000 rs2286886 chr9:129246177 T/C cg15282417 chr9:129245246 FAM125B 0.31 7.9 0.3 1.24e-14 Intraocular pressure; BRCA cis rs875971 0.964 rs6945019 chr7:65922458 C/G cg18876405 chr7:65276391 NA 0.55 13.01 0.46 1.64e-34 Aortic root size; BRCA cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.12 0.43 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg00814883 chr7:100076585 TSC22D4 -0.54 -10.74 -0.39 7.64e-25 Platelet count; BRCA cis rs7617773 0.817 rs79310258 chr3:48259667 C/G cg11946769 chr3:48343235 NME6 0.68 13.84 0.48 2.69e-38 Coronary artery disease; BRCA trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg26384229 chr12:38710491 ALG10B -0.61 -13.88 -0.48 1.75e-38 Morning vs. evening chronotype; BRCA cis rs10089 0.552 rs17607942 chr5:127555435 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.52 9.87 0.36 1.81e-21 Ileal carcinoids; BRCA trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.02 -0.34 2.13e-18 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.718 rs9847866 chr3:160758275 A/G cg04691961 chr3:161091175 C3orf57 -0.39 -8.2 -0.31 1.34e-15 Morning vs. evening chronotype; BRCA cis rs4363385 0.747 rs4478766 chr1:152984906 G/A cg24667326 chr1:152973720 SPRR3 -0.36 -10.03 -0.37 4.19e-22 Inflammatory skin disease; BRCA cis rs9527 0.590 rs12246739 chr10:104787019 A/C cg04362960 chr10:104952993 NT5C2 -0.44 -9.76 -0.36 4.45e-21 Arsenic metabolism; BRCA cis rs7523050 0.730 rs72984614 chr1:109435848 T/C cg08274380 chr1:109419600 GPSM2 1.18 16.83 0.55 6.67e-53 Fat distribution (HIV); BRCA cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg22509189 chr2:225307070 NA -0.47 -9.98 -0.37 6.87e-22 IgE levels in asthmatics (D.p. specific); BRCA cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg03351412 chr1:154909251 PMVK 0.58 13.76 0.48 6.23e-38 Prostate cancer; BRCA cis rs10267417 0.535 rs6960731 chr7:19869379 C/G cg07541023 chr7:19748670 TWISTNB -0.5 -8.99 -0.34 2.67e-18 Night sleep phenotypes; BRCA cis rs7131987 0.565 rs7976667 chr12:29426031 A/C cg09582351 chr12:29534625 ERGIC2 -0.37 -9.06 -0.34 1.53e-18 QT interval; BRCA cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg26031613 chr14:104095156 KLC1 -0.4 -8.07 -0.3 3.37e-15 Schizophrenia; BRCA cis rs798554 0.704 rs798512 chr7:2782592 C/G cg18446336 chr7:2847575 GNA12 -0.37 -8.5 -0.32 1.39e-16 Height; BRCA cis rs6964587 0.934 rs2961019 chr7:91572749 T/G cg17063962 chr7:91808500 NA -0.56 -12.09 -0.43 1.87e-30 Breast cancer; BRCA cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg22875332 chr1:76189707 ACADM 0.62 12.84 0.45 9.36e-34 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs11722228 0.549 rs2241488 chr4:10101131 T/C cg26043149 chr18:55253948 FECH 1.08 23.35 0.68 1.17e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs11051970 0.636 rs1045751 chr12:32569496 T/C cg02745156 chr12:32552066 NA 0.25 8.4 0.32 2.92e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg13319975 chr6:146136371 FBXO30 -0.34 -8.07 -0.3 3.49e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1953600 0.818 rs2152546 chr10:81906384 G/T cg04850286 chr10:81895943 PLAC9 -0.35 -10.22 -0.37 8.47e-23 Sarcoidosis; BRCA cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg01858014 chr14:56050164 KTN1 -0.73 -10.81 -0.39 3.79e-25 Putamen volume; BRCA cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg12311346 chr5:56204834 C5orf35 -0.99 -20.02 -0.62 1.45e-69 Initial pursuit acceleration; BRCA cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.67e-23 Motion sickness; BRCA cis rs10227331 0.846 rs10237006 chr7:157298250 A/G cg04156418 chr7:157293606 NA 0.33 9.45 0.35 6.12e-20 Inattentive symptoms; BRCA cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.1 0.4 2.69e-26 Electroencephalogram traits; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.61 -0.32 5.81e-17 Total body bone mineral density; BRCA cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg09021430 chr5:549028 NA -0.69 -15.85 -0.53 5.74e-48 Lung disease severity in cystic fibrosis; BRCA cis rs701145 0.640 rs357506 chr3:153932403 A/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.15 -0.4 1.74e-26 Schizophrenia; BRCA cis rs72781680 0.948 rs72796319 chr2:24133027 T/C cg08917208 chr2:24149416 ATAD2B 0.94 14.03 0.49 3.44e-39 Lymphocyte counts; BRCA trans rs9467711 0.790 rs13220495 chr6:26441640 C/T cg01620082 chr3:125678407 NA -0.84 -9.64 -0.36 1.27e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg22907277 chr7:1156413 C7orf50 0.46 10.57 0.39 3.44e-24 Longevity;Endometriosis; BRCA cis rs7944584 0.563 rs61895112 chr11:47560433 T/C cg03711944 chr11:47377212 SPI1 -0.44 -10.37 -0.38 2.11e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7715811 0.912 rs1502049 chr5:13779935 T/C cg07548982 chr5:13769939 DNAH5 -0.41 -9.37 -0.35 1.18e-19 Subclinical atherosclerosis traits (other); BRCA cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg02527881 chr3:46936655 PTH1R 0.35 8.23 0.31 1.09e-15 Birth weight; BRCA cis rs801193 0.901 rs4273746 chr7:66301111 C/T cg11764359 chr7:65958608 NA -0.59 -12.54 -0.44 2.17e-32 Aortic root size; BRCA cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs919433 0.713 rs11900232 chr2:198466273 T/C cg00792783 chr2:198669748 PLCL1 0.36 8.21 0.31 1.2e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg19318889 chr4:1322082 MAEA -0.47 -9.81 -0.36 2.89e-21 Obesity-related traits; BRCA cis rs3771570 0.792 rs4675970 chr2:242200406 G/A cg21155796 chr2:242212141 HDLBP 0.49 8.49 0.32 1.43e-16 Prostate cancer; BRCA cis rs3809566 1.000 rs3809566 chr15:63333724 A/G cg05507819 chr15:63340323 TPM1 0.43 9.24 0.34 3.7e-19 Platelet count; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg18402987 chr7:1209562 NA 0.58 11.41 0.41 1.49e-27 Longevity;Endometriosis; BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs11955398 0.585 rs1117675 chr5:60034886 C/T cg02684056 chr5:59996105 DEPDC1B -0.38 -9.06 -0.34 1.6e-18 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg25036284 chr2:26402008 FAM59B -0.64 -10.65 -0.39 1.75e-24 Gut microbiome composition (summer); BRCA cis rs7301826 0.651 rs4759521 chr12:131297313 C/T cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 3e-37 Plasma plasminogen activator levels; BRCA cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg10523679 chr1:76189770 ACADM -0.77 -16.23 -0.54 7.59e-50 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg16606324 chr3:10149918 C3orf24 0.53 10.45 0.38 1.04e-23 Alzheimer's disease; BRCA cis rs56804039 1.000 rs17616779 chr8:8382374 A/G cg06636001 chr8:8085503 FLJ10661 0.53 8.8 0.33 1.29e-17 Cervical cancer; BRCA cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.35 -0.31 4.31e-16 Electroencephalogram traits; BRCA cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg13010199 chr12:38710504 ALG10B 0.4 8.24 0.31 1e-15 Bladder cancer; BRCA cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.33 -0.44 1.66e-31 Developmental language disorder (linguistic errors); BRCA cis rs758324 0.898 rs6877358 chr5:131111360 G/A cg06307176 chr5:131281290 NA 0.53 10.26 0.38 5.65e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg08000102 chr2:233561755 GIGYF2 0.63 13.95 0.48 8.42e-39 Coronary artery disease; BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg27170947 chr2:26402098 FAM59B 0.7 11.76 0.42 4.93e-29 Gut microbiome composition (summer); BRCA cis rs12042938 0.600 rs823163 chr1:231771108 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.4 8.92 0.33 5.07e-18 Neuranatomic and neurocognitive phenotypes; BRCA cis rs7085104 0.572 rs284857 chr10:104574063 C/T cg04362960 chr10:104952993 NT5C2 -0.33 -7.95 -0.3 8.46e-15 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs2070488 0.804 rs7646429 chr3:38467713 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.65 17.11 0.56 2.53e-54 Electrocardiographic conduction measures; BRCA cis rs244731 0.959 rs6872021 chr5:176610012 G/A cg16006841 chr5:176797999 RGS14 -0.69 -10.95 -0.4 1.08e-25 Urate levels in lean individuals; BRCA cis rs4595586 0.545 rs1356265 chr12:39403696 A/G cg26384229 chr12:38710491 ALG10B 0.4 9.14 0.34 8.43e-19 Morning vs. evening chronotype; BRCA cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.99 -0.4 7.22e-26 Mean corpuscular volume; BRCA trans rs1997103 0.765 rs55686950 chr7:55396552 A/C cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.06 -0.34 1.55e-18 Intelligence (multi-trait analysis); BRCA cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg02564969 chr6:151773285 C6orf211;RMND1 -0.36 -8.45 -0.32 1.94e-16 Menarche (age at onset); BRCA cis rs1577917 0.740 rs2475792 chr6:86392102 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.33 9.21 0.34 4.71e-19 Response to antipsychotic treatment; BRCA cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg08917208 chr2:24149416 ATAD2B 0.93 13.87 0.48 1.91e-38 Lymphocyte counts; BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs12188164 0.580 rs2672755 chr5:457249 G/T cg16584290 chr5:462447 EXOC3 0.51 14.17 0.49 7.4e-40 Cystic fibrosis severity; BRCA cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.39 -0.35 1.06e-19 Alzheimer's disease (late onset); BRCA cis rs910316 1.000 rs910316 chr14:75626042 A/C cg11812906 chr14:75593930 NEK9 0.7 16.13 0.54 2.24e-49 Height; BRCA trans rs2204008 0.627 rs11176531 chr12:38152166 T/G cg06521331 chr12:34319734 NA -0.54 -9.58 -0.35 2.14e-20 Bladder cancer; BRCA cis rs61990749 0.597 rs12887606 chr14:78200620 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.59 0.39 2.86e-24 Fibroblast growth factor basic levels; BRCA cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg24558204 chr6:135376177 HBS1L 0.58 15.52 0.52 2.57e-46 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs66530629 1.000 rs7520844 chr1:25054223 C/G cg01905478 chr1:25040257 NA -0.35 -7.93 -0.3 9.55e-15 Plateletcrit; BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.6 10.19 0.37 1.04e-22 Renal function-related traits (BUN); BRCA cis rs12541635 0.934 rs60482457 chr8:106970504 A/G cg10147462 chr8:107024639 NA 0.35 9.59 0.35 1.94e-20 Age of smoking initiation; BRCA cis rs6750047 0.719 rs100489 chr2:38266478 T/C cg07380506 chr2:38303506 CYP1B1 -0.43 -9.58 -0.35 2.05e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs11608355 0.515 rs11614551 chr12:109931630 G/A cg05360138 chr12:110035743 NA 0.72 13.3 0.47 8.56e-36 Neuroticism; BRCA cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05535760 chr7:792225 HEATR2 0.86 14.44 0.5 4.06e-41 Cerebrospinal P-tau181p levels; BRCA cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg18876405 chr7:65276391 NA -0.56 -13.35 -0.47 4.89e-36 Aortic root size; BRCA cis rs2479724 0.776 rs2250428 chr6:41832772 T/A cg17623882 chr6:41773611 USP49 -0.34 -9.02 -0.34 2.17e-18 Menarche (age at onset); BRCA cis rs758324 0.947 rs4705900 chr5:131140241 G/A cg06307176 chr5:131281290 NA 0.53 10.22 0.37 8.32e-23 Alzheimer's disease in APOE e4- carriers; BRCA trans rs61931739 0.534 rs11052974 chr12:34029877 T/G cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.87e-20 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg11062466 chr8:58055876 NA 0.42 7.92 0.3 1.03e-14 Developmental language disorder (linguistic errors); BRCA cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.95 0.43 7.75e-30 Personality dimensions; BRCA cis rs597539 0.652 rs496616 chr11:68672800 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.55 0.59 8.71e-62 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg07148914 chr20:33460835 GGT7 -0.43 -9.41 -0.35 8.86e-20 Height; BRCA cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg25427524 chr10:38739819 LOC399744 0.67 16.32 0.54 2.5e-50 Extrinsic epigenetic age acceleration; BRCA trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg08975724 chr8:8085496 FLJ10661 -0.43 -9.17 -0.34 6.55e-19 Neuroticism; BRCA cis rs2404602 0.569 rs283793 chr15:76774752 G/A cg23625390 chr15:77176239 SCAPER 0.5 11.77 0.42 4.33e-29 Blood metabolite levels; BRCA cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg02734326 chr4:10020555 SLC2A9 0.4 8.55 0.32 9.11e-17 Bone mineral density; BRCA cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg07148914 chr20:33460835 GGT7 -0.36 -7.85 -0.3 1.73e-14 Glomerular filtration rate (creatinine); BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.29 0.41 4.64e-27 Platelet count; BRCA cis rs11105298 0.891 rs10858852 chr12:89833338 T/C cg00757033 chr12:89920650 WDR51B 0.54 10.82 0.39 3.61e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg04455712 chr21:45112962 RRP1B -0.38 -9.86 -0.36 1.91e-21 Mean corpuscular volume; BRCA cis rs7264396 0.690 rs2425165 chr20:34438059 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.45 -0.52 5.35e-46 Total cholesterol levels; BRCA cis rs6570726 0.935 rs374000 chr6:145855290 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.92 0.51 2e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00149659 chr3:10157352 C3orf10 0.71 12.54 0.44 2.2e-32 Alzheimer's disease; BRCA cis rs7903847 0.620 rs11189168 chr10:99125769 T/C cg08345082 chr10:99160200 RRP12 -0.28 -7.95 -0.3 8.45e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.31 -0.31 5.71e-16 Total body bone mineral density; BRCA cis rs78456975 0.739 rs28913003 chr2:1519620 A/T cg01028140 chr2:1542097 TPO -0.69 -13.79 -0.48 4.63e-38 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg06784218 chr1:46089804 CCDC17 0.46 10.9 0.4 1.78e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9467160 0.520 rs2753910 chr6:24442473 C/T cg20631270 chr6:24437470 GPLD1 -0.55 -11.53 -0.41 4.63e-28 Liver enzyme levels; BRCA cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.78 17.16 0.56 1.41e-54 Smoking behavior; BRCA cis rs736408 0.561 rs2276815 chr3:52853747 C/G cg18404041 chr3:52824283 ITIH1 -0.38 -10.39 -0.38 1.85e-23 Bipolar disorder; BRCA cis rs7246657 0.714 rs12972195 chr19:37752505 T/C cg23950597 chr19:37808831 NA -0.6 -10.61 -0.39 2.51e-24 Coronary artery calcification; BRCA cis rs6598955 0.543 rs61608823 chr1:26555090 G/A cg04990556 chr1:26633338 UBXN11 0.71 11.94 0.43 8.06e-30 Obesity-related traits; BRCA cis rs9467711 0.651 rs2237228 chr6:26104630 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.6 9.13 0.34 8.93e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs6785206 0.772 rs2811493 chr3:128357299 C/G cg16766828 chr3:128327626 NA -0.79 -11.37 -0.41 1.98e-27 Lymphocyte percentage of white cells; BRCA cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.874 rs17839089 chr4:120111069 A/G cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.8e-24 Corneal astigmatism; BRCA cis rs2806561 0.514 rs7414010 chr1:23543929 T/C cg24466277 chr1:23519622 HTR1D -0.4 -8.58 -0.32 7.38e-17 Height; BRCA cis rs3774749 0.565 rs2188151 chr3:50201924 A/C cg14019146 chr3:50243930 SLC38A3 0.46 11.44 0.41 1.05e-27 Intelligence (multi-trait analysis); BRCA cis rs9341808 0.618 rs6916507 chr6:80862265 T/C cg08355045 chr6:80787529 NA 0.37 9.33 0.35 1.78e-19 Sitting height ratio; BRCA cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg12365402 chr11:9010492 NRIP3 -0.41 -9.58 -0.35 2.08e-20 Hemoglobin concentration; BRCA cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg13256891 chr4:100009986 ADH5 0.54 9.93 0.37 1.04e-21 Smoking initiation; BRCA cis rs1372520 0.748 rs1471484 chr4:90754313 C/T cg15133208 chr4:90757351 SNCA -0.43 -8.62 -0.32 5.06e-17 Neuroticism; BRCA cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.53 -11.54 -0.42 3.94e-28 IgG glycosylation; BRCA cis rs2304069 0.779 rs245081 chr5:149356075 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.56 12.31 0.44 2.21e-31 HIV-1 control; BRCA cis rs7847628 0.587 rs3793638 chr9:123582697 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.95 26.07 0.72 1.32e-102 Birth weight; BRCA trans rs4718428 0.672 rs36038499 chr7:66289615 A/G cg18876405 chr7:65276391 NA 0.44 8.43 0.32 2.3e-16 Corneal structure; BRCA cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11644478 chr21:40555479 PSMG1 0.84 19.3 0.61 9.57e-66 Cognitive function; BRCA cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg01877450 chr7:97915802 BRI3 -0.38 -8.53 -0.32 1.09e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7772486 0.875 rs2224120 chr6:146343280 A/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.3 -0.31 6.19e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7089973 0.604 rs10885618 chr10:116617718 A/G cg23260525 chr10:116636907 FAM160B1 0.3 7.98 0.3 7.04e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs17685 0.712 rs11770149 chr7:75791644 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -7.85 -0.3 1.72e-14 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg17063962 chr7:91808500 NA 0.56 12.65 0.45 7.2e-33 Breast cancer; BRCA cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg13319975 chr6:146136371 FBXO30 0.41 9.22 0.34 4.41e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs7590720 1.000 rs7590720 chr2:216898658 A/G cg12620499 chr2:216877984 MREG -0.8 -22.36 -0.66 3.02e-82 Alcohol dependence; BRCA cis rs13046373 0.507 rs8133828 chr21:32033046 C/G cg16431978 chr21:31797932 KRTAP13-3 0.37 8.85 0.33 8.33e-18 HDL cholesterol; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg04166393 chr7:2884313 GNA12 0.5 9.17 0.34 6.41e-19 Height; BRCA cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg04455712 chr21:45112962 RRP1B -0.34 -8.5 -0.32 1.31e-16 Mean corpuscular volume; BRCA cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg03060546 chr3:49711283 APEH 0.58 8.42 0.32 2.57e-16 Menarche (age at onset); BRCA cis rs2243480 1.000 rs316330 chr7:65605372 C/A cg18252515 chr7:66147081 NA -1.05 -15.69 -0.53 3.48e-47 Diabetic kidney disease; BRCA cis rs4690686 0.769 rs11133146 chr4:177278878 C/T cg17059388 chr4:177262070 NA -0.37 -8.19 -0.31 1.37e-15 Essential tremor; BRCA cis rs1865721 0.682 rs35282535 chr18:73141206 G/A cg26385618 chr18:73139727 C18orf62 -0.37 -9.4 -0.35 9.95e-20 Intelligence; BRCA cis rs7647973 0.593 rs7620848 chr3:49828021 G/C cg07636037 chr3:49044803 WDR6 -0.5 -8.25 -0.31 9.35e-16 Menarche (age at onset); BRCA cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5e-22 Morning vs. evening chronotype; BRCA cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.37 -0.38 2.18e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6433895 1.000 rs6433895 chr2:182012014 A/C cg00481216 chr2:181971175 NA 0.37 8.54 0.32 9.6e-17 Lymphocyte counts; BRCA cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.02e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10267417 0.603 rs12333603 chr7:19907821 C/G cg07541023 chr7:19748670 TWISTNB -0.46 -8.53 -0.32 1.09e-16 Night sleep phenotypes; BRCA cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg14844989 chr11:31128820 NA -0.44 -9.89 -0.36 1.49e-21 Red blood cell count; BRCA cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.03 -0.34 1.96e-18 Alzheimer's disease (late onset); BRCA cis rs7582180 0.764 rs920269 chr2:100918363 G/A cg14675211 chr2:100938903 LONRF2 0.47 10.81 0.39 3.93e-25 Intelligence (multi-trait analysis); BRCA cis rs739401 0.527 rs418832 chr11:3072236 C/T cg08508325 chr11:3079039 CARS -0.45 -16.31 -0.54 3.01e-50 Longevity; BRCA trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg13010199 chr12:38710504 ALG10B 0.42 9.0 0.34 2.56e-18 Morning vs. evening chronotype; BRCA cis rs4808199 0.948 rs2074300 chr19:19380996 G/T cg03709012 chr19:19516395 GATAD2A 0.96 16.98 0.56 1.2e-53 Nonalcoholic fatty liver disease; BRCA cis rs2012796 1.000 rs10450894 chr14:81825172 T/A cg02996355 chr14:81879375 NA 0.5 9.79 0.36 3.63e-21 Night sleep phenotypes; BRCA cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg09184832 chr6:79620586 NA -0.48 -10.46 -0.38 9.77e-24 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg18132916 chr6:79620363 NA -0.49 -11.02 -0.4 5.71e-26 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.59 -12.31 -0.44 2.1e-31 Lymphocyte counts; BRCA cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg08219700 chr8:58056026 NA 0.45 8.14 0.31 2.05e-15 Developmental language disorder (linguistic errors); BRCA cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg13010199 chr12:38710504 ALG10B -0.41 -8.75 -0.33 1.91e-17 Morning vs. evening chronotype; BRCA cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg12365402 chr11:9010492 NRIP3 0.43 9.39 0.35 1.01e-19 Hemoglobin concentration; BRCA cis rs66569888 0.789 rs17213510 chr2:106742778 T/C cg23109721 chr2:106886537 NA -0.49 -8.36 -0.31 3.79e-16 Facial morphology (factor 23); BRCA trans rs801193 0.967 rs34356500 chr7:66236607 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.35 7.81 0.3 2.31e-14 Aortic root size; BRCA cis rs7707921 0.767 rs862241 chr5:81588011 G/A cg15871215 chr5:81402204 ATG10 0.35 8.32 0.31 5.42e-16 Breast cancer; BRCA cis rs3760982 0.585 rs67648499 chr19:44294055 G/A cg11993925 chr19:44307056 LYPD5 0.38 8.96 0.33 3.64e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg05707623 chr12:122985044 ZCCHC8 -0.42 -8.61 -0.32 5.71e-17 Body mass index; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg13880726 chr7:1868755 MAD1L1 0.52 9.81 0.36 2.84e-21 Bipolar disorder and schizophrenia; BRCA cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg07308232 chr7:1071921 C7orf50 -0.42 -8.67 -0.32 3.65e-17 Longevity;Endometriosis; BRCA cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg00071950 chr4:10020882 SLC2A9 -0.54 -13.19 -0.46 2.53e-35 Bone mineral density; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg00106254 chr7:1943704 MAD1L1 -0.43 -10.97 -0.4 8.65e-26 Bipolar disorder and schizophrenia; BRCA cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -8.67 -0.32 3.48e-17 Personality dimensions; BRCA cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg15017067 chr4:17643749 FAM184B 0.26 7.81 0.3 2.31e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs921968 0.643 rs3932856 chr2:219320207 C/A cg02176678 chr2:219576539 TTLL4 0.39 10.48 0.38 8.11e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs950173 1.000 rs13000153 chr2:172586067 A/G cg13550731 chr2:172543902 DYNC1I2 -0.73 -10.94 -0.4 1.21e-25 Hippocampal volume; BRCA cis rs868036 0.560 rs12443086 chr15:68080454 C/A cg08079166 chr15:68083412 MAP2K5 0.31 8.26 0.31 8.51e-16 Restless legs syndrome; BRCA cis rs7707921 0.881 rs73136777 chr5:81434479 T/A cg15871215 chr5:81402204 ATG10 -0.41 -8.55 -0.32 9.04e-17 Breast cancer; BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg11584989 chr19:19387371 SF4 0.31 7.89 0.3 1.33e-14 Tonsillectomy; BRCA cis rs6840360 0.638 rs6816002 chr4:152589439 C/T cg25486957 chr4:152246857 NA -0.34 -8.18 -0.31 1.59e-15 Intelligence (multi-trait analysis); BRCA cis rs10129255 0.500 rs8006888 chr14:107190456 A/C cg07958169 chr14:107095056 NA -0.4 -8.71 -0.33 2.69e-17 Kawasaki disease; BRCA cis rs6820391 0.663 rs17083088 chr4:54448574 C/T cg04173182 chr4:54446035 LNX1 0.47 10.75 0.39 6.93e-25 Cervical artery dissection; BRCA cis rs11250464 0.833 rs11250466 chr10:1409378 C/T cg08668359 chr10:1443807 ADARB2 0.47 9.31 0.35 2.01e-19 Radiation response; BRCA cis rs10911251 0.546 rs3768625 chr1:183078712 G/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.97 0.58 9.15e-59 Colorectal cancer; BRCA cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg09184832 chr6:79620586 NA -0.51 -10.98 -0.4 8.19e-26 Intelligence (multi-trait analysis); BRCA cis rs7246657 1.000 rs7247672 chr19:37743928 A/G cg18154014 chr19:37997991 ZNF793 0.55 10.28 0.38 4.63e-23 Coronary artery calcification; BRCA cis rs12200782 0.505 rs7765920 chr6:26514771 C/T cg09904177 chr6:26538194 HMGN4 0.4 9.25 0.34 3.46e-19 Small cell lung carcinoma; BRCA cis rs870825 0.549 rs28579266 chr4:185627262 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg24110177 chr3:50126178 RBM5 0.37 10.09 0.37 2.49e-22 Menarche (age at onset); BRCA cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.09 0.4 2.83e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg02017074 chr12:117425053 FBXW8 -0.57 -10.36 -0.38 2.3e-23 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.94 0.33 4.11e-18 Tonsillectomy; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.7 -0.33 2.85e-17 Total body bone mineral density; BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00166722 chr3:10149974 C3orf24 0.6 10.69 0.39 1.19e-24 Alzheimer's disease; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.37e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs8002861 0.967 rs7999434 chr13:44482961 T/C cg17145862 chr1:211918768 LPGAT1 0.69 18.15 0.58 1.04e-59 Leprosy; BRCA cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.23 0.41 7.6e-27 Bipolar disorder; BRCA trans rs3857536 0.813 rs7769683 chr6:66946256 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.525 rs11609150 chr12:39408622 A/C cg26384229 chr12:38710491 ALG10B 0.55 11.72 0.42 6.9e-29 Morning vs. evening chronotype; BRCA trans rs9858542 0.953 rs6809216 chr3:49412559 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.05 -0.34 1.73e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg00149659 chr3:10157352 C3orf10 0.8 13.73 0.48 9.11e-38 Alzheimer's disease; BRCA cis rs68170813 0.559 rs7807648 chr7:106965091 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.22 -0.31 1.17e-15 Coronary artery disease; BRCA cis rs7914558 0.966 rs11191471 chr10:104702050 T/A cg04362960 chr10:104952993 NT5C2 0.43 10.38 0.38 2.03e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 9.1e-15 Corneal astigmatism; BRCA cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg05234568 chr11:5960015 NA 0.49 9.99 0.37 6.13e-22 DNA methylation (variation); BRCA cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg26395211 chr5:140044315 WDR55 0.38 8.62 0.32 5.29e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg13877915 chr19:58951672 ZNF132 0.46 10.8 0.39 4.43e-25 Uric acid clearance; BRCA cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.91 0.3 1.16e-14 Axial length; BRCA cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg14993813 chr1:46806288 NSUN4 -0.47 -9.07 -0.34 1.48e-18 Menopause (age at onset); BRCA cis rs113835537 0.529 rs116867234 chr11:66209024 C/T cg24851651 chr11:66362959 CCS 0.5 8.71 0.33 2.51e-17 Airway imaging phenotypes; BRCA cis rs3892630 0.818 rs80137870 chr19:33182750 C/T cg22980127 chr19:33182716 NUDT19 0.9 18.18 0.58 7.62e-60 Red blood cell traits; BRCA cis rs34779708 0.931 rs58159560 chr10:35351249 C/T cg03585969 chr10:35415529 CREM 0.56 11.49 0.41 6.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg22875332 chr1:76189707 ACADM 0.64 11.9 0.43 1.18e-29 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs2262909 0.962 rs1526884 chr19:22303651 A/G cg17074339 chr11:11642133 GALNTL4 0.45 8.89 0.33 6.2e-18 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs6121246 0.909 rs4518038 chr20:30419051 A/G cg13852791 chr20:30311386 BCL2L1 0.77 11.3 0.41 4.02e-27 Mean corpuscular hemoglobin; BRCA trans rs11088226 1.000 rs2833889 chr21:33927768 G/T cg09050820 chr6:167586206 TCP10L2 -0.5 -8.71 -0.33 2.6e-17 Gastritis; BRCA cis rs6942756 0.713 rs691158 chr7:129129982 G/T cg02491457 chr7:128862824 NA -0.55 -11.17 -0.4 1.34e-26 White matter hyperintensity burden; BRCA cis rs2197308 0.692 rs7488528 chr12:37912971 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.55 0.35 2.81e-20 Morning vs. evening chronotype; BRCA cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12516959 chr21:47718080 NA 0.41 9.43 0.35 7.23e-20 Testicular germ cell tumor; BRCA cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg11279151 chr3:101281821 RG9MTD1 0.38 8.67 0.32 3.47e-17 Colorectal cancer; BRCA cis rs7412746 0.658 rs7528773 chr1:150915875 G/A cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.19e-14 Melanoma; BRCA trans rs11039798 0.925 rs7929225 chr11:48931739 G/C cg15704280 chr7:45808275 SEPT13 0.6 8.93 0.33 4.6e-18 Axial length; BRCA cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg08603382 chr10:743973 NA -0.46 -8.51 -0.32 1.25e-16 Psychosis in Alzheimer's disease; BRCA cis rs4481887 0.830 rs4474289 chr1:248474972 T/A cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.46e-16 Common traits (Other); BRCA cis rs6598955 0.671 rs12145403 chr1:26597189 C/T cg04990556 chr1:26633338 UBXN11 0.53 8.77 0.33 1.55e-17 Obesity-related traits; BRCA cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg05234568 chr11:5960015 NA -0.52 -10.27 -0.38 5.4e-23 DNA methylation (variation); BRCA cis rs208520 0.690 rs4710311 chr6:66823223 C/T cg07460842 chr6:66804631 NA -0.93 -18.93 -0.6 8.65e-64 Exhaled nitric oxide output; BRCA cis rs2635047 0.875 rs2635040 chr18:44640972 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 7.91 0.3 1.16e-14 Educational attainment; BRCA cis rs427394 0.659 rs274717 chr5:6721067 C/T cg10857441 chr5:6722123 POLS 0.3 9.64 0.36 1.29e-20 Menopause (age at onset); BRCA cis rs12210905 0.688 rs12212389 chr6:27326397 T/C cg08851530 chr6:28072375 NA 0.91 8.7 0.33 2.7e-17 Hip circumference adjusted for BMI; BRCA cis rs9359856 0.623 rs7742602 chr6:90327385 A/G cg13799429 chr6:90582589 CASP8AP2 -0.5 -8.2 -0.31 1.35e-15 Bipolar disorder; BRCA cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg15595755 chr5:1867978 NA 0.36 8.55 0.32 8.94e-17 Cardiovascular disease risk factors; BRCA cis rs6893300 0.776 rs56396231 chr5:179157298 T/G cg14593053 chr5:179126677 CANX -0.35 -7.9 -0.3 1.19e-14 Resting heart rate; BRCA cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -18.1 -0.58 2.13e-59 Extrinsic epigenetic age acceleration; BRCA cis rs921968 0.565 rs7580147 chr2:219643036 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.82 -0.39 3.47e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs7975161 0.572 rs10861163 chr12:104568613 C/A cg25273343 chr12:104657179 TXNRD1 -0.5 -8.63 -0.32 4.99e-17 Toenail selenium levels; BRCA cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs877529 0.967 rs139406 chr22:39551798 T/C cg12193277 chr22:39547181 CBX7 0.46 12.54 0.44 1.99e-32 Multiple myeloma; BRCA cis rs2370759 1.000 rs76998371 chr10:32631785 A/G cg18270830 chr10:32634957 EPC1 0.61 10.27 0.38 5.45e-23 Sexual dysfunction (female); BRCA cis rs7809950 0.678 rs4730235 chr7:107022506 T/C cg23024343 chr7:107201750 COG5 -0.47 -9.81 -0.36 3.03e-21 Coronary artery disease; BRCA cis rs28735056 0.592 rs10853392 chr18:77708781 A/G cg20368463 chr18:77673604 PQLC1 -0.33 -8.39 -0.31 3.22e-16 Schizophrenia; BRCA cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg18964960 chr10:1102726 WDR37 0.53 9.2 0.34 5.2e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs34891900 0.507 rs2535707 chr22:18181869 C/T cg19898043 chr22:18121309 BCL2L13 -0.46 -9.8 -0.36 3.2e-21 Sum neutrophil eosinophil counts; BRCA cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg18305652 chr10:134549665 INPP5A 0.5 11.49 0.41 6.68e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg19729930 chr2:74357872 NA 0.54 13.99 0.48 5.62e-39 Gestational age at birth (maternal effect); BRCA cis rs6815814 0.898 rs73236646 chr4:38871385 T/C cg02016764 chr4:38805732 TLR1 -0.52 -8.12 -0.31 2.47e-15 Breast cancer; BRCA cis rs1371867 0.846 rs1788206 chr8:101306966 A/G cg06002616 chr8:101225028 SPAG1 -0.34 -8.34 -0.31 4.47e-16 Atrioventricular conduction; BRCA cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 10.54 0.38 4.74e-24 Aortic root size; BRCA cis rs4819052 0.679 rs4819053 chr21:46711357 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.43 -9.5 -0.35 4.28e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.96 0.33 3.49e-18 Motion sickness; BRCA cis rs1580019 0.961 rs766660 chr7:32499077 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.55 0.32 9.24e-17 Cognitive ability; BRCA cis rs7586879 0.964 rs13412941 chr2:25102709 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.48 0.35 4.77e-20 Body mass index; BRCA cis rs6541297 0.775 rs4846910 chr1:230291441 C/A cg20703242 chr1:230279135 GALNT2 0.46 9.36 0.35 1.34e-19 Coronary artery disease; BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg11062466 chr8:58055876 NA 0.52 9.13 0.34 8.75e-19 Developmental language disorder (linguistic errors); BRCA cis rs4077515 0.967 rs4567159 chr9:139277059 G/A cg14019695 chr9:139328340 INPP5E 0.32 8.06 0.3 3.81e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs586533 0.846 rs609750 chr11:99497099 G/T cg22878054 chr11:99397252 CNTN5 0.32 8.02 0.3 5.08e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7726839 0.561 rs72703046 chr5:580129 T/C cg09021430 chr5:549028 NA -0.64 -15.19 -0.52 1.04e-44 Obesity-related traits; BRCA cis rs7833986 0.501 rs2976044 chr8:56986737 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.54 11.39 0.41 1.76e-27 Height; BRCA cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs9790314 1.000 rs336583 chr3:161081981 A/T cg03342759 chr3:160939853 NMD3 0.63 13.52 0.47 8.35e-37 Morning vs. evening chronotype; BRCA cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg24675658 chr1:53192096 ZYG11B 0.63 15.2 0.52 8.74e-45 Monocyte count; BRCA cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg25838465 chr1:92012736 NA -0.64 -19.04 -0.6 2.27e-64 Breast cancer; BRCA cis rs61931739 0.534 rs2389276 chr12:34097891 T/C cg06521331 chr12:34319734 NA -0.62 -12.24 -0.44 4.36e-31 Morning vs. evening chronotype; BRCA cis rs4660306 0.961 rs3748643 chr1:45965703 G/T cg24296786 chr1:45957014 TESK2 0.42 8.42 0.32 2.52e-16 Homocysteine levels; BRCA cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg11266682 chr4:10021025 SLC2A9 0.5 13.18 0.46 3.04e-35 Bone mineral density; BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg22535103 chr8:58192502 C8orf71 -0.5 -8.72 -0.33 2.47e-17 Developmental language disorder (linguistic errors); BRCA cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg08704250 chr15:31115839 NA -0.36 -8.89 -0.33 6.4e-18 Huntington's disease progression; BRCA cis rs4689388 0.853 rs6446479 chr4:6291737 G/C cg25554036 chr4:6271136 WFS1 0.41 9.72 0.36 6.5e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7567389 0.740 rs1604817 chr2:127999921 C/T cg09760422 chr2:128146352 NA -0.41 -8.76 -0.33 1.78e-17 Self-rated health; BRCA cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg21132104 chr15:45694354 SPATA5L1 0.62 12.26 0.44 3.56e-31 Homoarginine levels; BRCA cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.87 0.33 7.48e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg18876405 chr7:65276391 NA 0.59 14.59 0.5 7.67e-42 Aortic root size; BRCA cis rs2836633 1.000 rs11088437 chr21:40053372 A/G cg05519781 chr21:40033154 ERG 0.41 8.42 0.32 2.55e-16 Coronary artery disease; BRCA cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -8.43 -0.32 2.23e-16 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.67e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.534 rs4931783 chr12:34115322 G/A cg26384229 chr12:38710491 ALG10B 0.66 13.86 0.48 2.1e-38 Morning vs. evening chronotype; BRCA cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg23029597 chr12:123009494 RSRC2 -0.47 -9.63 -0.36 1.34e-20 Body mass index; BRCA cis rs2243480 0.908 rs4718273 chr7:65216099 G/A cg18252515 chr7:66147081 NA 0.9 12.95 0.46 3.18e-34 Diabetic kidney disease; BRCA cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg06064525 chr11:970664 AP2A2 -0.3 -8.9 -0.33 5.84e-18 Alzheimer's disease (late onset); BRCA trans rs3780486 0.846 rs2209948 chr9:33138247 G/A cg20290983 chr6:43655470 MRPS18A 1.11 40.51 0.85 1.2e-178 IgG glycosylation; BRCA cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg17845761 chr1:175162550 KIAA0040 0.26 9.92 0.37 1.17e-21 Alcohol dependence; BRCA cis rs7011049 1.000 rs78200075 chr8:53845907 G/A cg26025543 chr8:53854495 NA 0.53 9.06 0.34 1.59e-18 Systolic blood pressure; BRCA cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11890956 chr21:40555474 PSMG1 1.01 24.77 0.7 1.94e-95 Cognitive function; BRCA cis rs4722404 0.502 rs13234017 chr7:3110587 C/A cg19214707 chr7:3157722 NA -0.37 -7.84 -0.3 1.89e-14 Atopic dermatitis; BRCA cis rs826838 1.000 rs1684395 chr12:39083161 T/G cg13010199 chr12:38710504 ALG10B -0.41 -9.6 -0.35 1.85e-20 Heart rate; BRCA cis rs7011049 0.673 rs72640836 chr8:53828023 G/T cg26025543 chr8:53854495 NA 0.43 7.85 0.3 1.8e-14 Systolic blood pressure; BRCA cis rs61990749 0.544 rs12435761 chr14:78246077 C/G cg02301378 chr14:78227641 SNW1;C14orf178 0.57 9.27 0.34 2.92e-19 Fibroblast growth factor basic levels; BRCA cis rs17253792 0.822 rs77676035 chr14:56096229 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 1.97e-48 Bladder cancer; BRCA cis rs56804039 1.000 rs11780966 chr8:8383396 T/G cg06636001 chr8:8085503 FLJ10661 -0.52 -8.78 -0.33 1.47e-17 Cervical cancer; BRCA cis rs1577917 1.000 rs4706254 chr6:86602813 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -11.02 -0.4 5.9e-26 Response to antipsychotic treatment; BRCA cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg27446573 chr6:127587934 RNF146 0.89 20.34 0.63 2.6e-71 Breast cancer; BRCA cis rs13031619 0.517 rs10183413 chr2:3684342 T/C cg19052272 chr2:3704530 ALLC 0.44 9.43 0.35 7.36e-20 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2180341 0.814 rs6919082 chr6:127737888 T/G cg24812749 chr6:127587940 RNF146 0.66 14.74 0.5 1.56e-42 Breast cancer; BRCA cis rs9646954 0.542 rs4149510 chr2:101023635 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.65 0.42 1.37e-28 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.648 rs2002047 chr4:120257228 A/G cg09307838 chr4:120376055 NA 0.63 13.63 0.47 2.45e-37 Corneal astigmatism; BRCA cis rs36051895 0.695 rs62541534 chr9:5028921 C/G cg02405213 chr9:5042618 JAK2 -0.51 -9.05 -0.34 1.74e-18 Pediatric autoimmune diseases; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg18402987 chr7:1209562 NA 0.84 12.05 0.43 2.8e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg14863265 chr7:2801509 GNA12 -0.42 -9.03 -0.34 1.93e-18 Height; BRCA cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.7 -20.51 -0.63 3.32e-72 Age-related macular degeneration (geographic atrophy); BRCA cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg12292205 chr6:26970375 C6orf41 -0.62 -10.66 -0.39 1.63e-24 Intelligence (multi-trait analysis); BRCA cis rs9462027 0.606 rs7756009 chr6:34715395 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 8.03e-15 Systemic lupus erythematosus; BRCA trans rs11098499 0.738 rs28687057 chr4:120280812 A/G cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA cis rs733592 0.507 rs3825403 chr12:48457159 G/A cg24011408 chr12:48396354 COL2A1 -0.44 -9.85 -0.36 2.05e-21 Plateletcrit; BRCA cis rs9462027 0.606 rs7759227 chr6:34728230 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.01 -0.3 5.4e-15 Systemic lupus erythematosus; BRCA cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.4 -8.58 -0.32 7.43e-17 Alzheimer's disease (late onset); BRCA cis rs738322 0.600 rs4821751 chr22:38564457 T/C cg25457927 chr22:38595422 NA -0.35 -12.97 -0.46 2.48e-34 Cutaneous nevi; BRCA cis rs142483589 1 rs142483589 chr9:139320323 CCG/C cg14019695 chr9:139328340 INPP5E 0.39 8.32 0.31 5.16e-16 White blood cell count; BRCA cis rs6138458 1.000 rs227629 chr20:24913551 G/T cg06937882 chr20:24974362 C20orf3 -0.44 -8.41 -0.32 2.76e-16 Blood protein levels; BRCA cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.48e-23 Motion sickness; BRCA trans rs11098499 0.739 rs10013032 chr4:120149419 C/T cg25214090 chr10:38739885 LOC399744 -0.46 -9.84 -0.36 2.35e-21 Corneal astigmatism; BRCA cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs929596 0.785 rs11695484 chr2:234654449 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -12.06 -0.43 2.45e-30 Total bilirubin levels in HIV-1 infection; BRCA cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg07636037 chr3:49044803 WDR6 -0.81 -21.08 -0.64 2.61e-75 Menarche (age at onset); BRCA cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg19784903 chr17:45786737 TBKBP1 -0.35 -8.43 -0.32 2.31e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs586533 0.846 rs602800 chr11:99499947 A/T cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs4363385 0.693 rs76987906 chr1:152964530 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.07 -0.34 1.44e-18 Inflammatory skin disease; BRCA cis rs1448094 0.520 rs12304244 chr12:86272823 C/T cg19622623 chr12:86230825 RASSF9 -0.32 -8.68 -0.32 3.37e-17 Major depressive disorder; BRCA cis rs9325144 0.560 rs1843910 chr12:38677408 T/C cg26384229 chr12:38710491 ALG10B -0.53 -13.66 -0.48 1.81e-37 Morning vs. evening chronotype; BRCA trans rs2727020 0.521 rs7126835 chr11:49594658 T/C cg15704280 chr7:45808275 SEPT13 -0.72 -14.61 -0.5 6.32e-42 Coronary artery disease; BRCA cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.72 -0.42 7.09e-29 Glomerular filtration rate (creatinine); BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg13047869 chr3:10149882 C3orf24 0.55 10.3 0.38 4.02e-23 Alzheimer's disease; BRCA cis rs1691799 0.899 rs1168308 chr12:66742183 A/G cg16791601 chr12:66731901 HELB -0.65 -17.6 -0.57 7.75e-57 White blood cell count (basophil); BRCA cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9649465 0.967 rs10487806 chr7:123314446 C/T cg04330084 chr7:123175371 IQUB 0.31 8.33 0.31 4.93e-16 Migraine; BRCA cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.64 0.55 6.78e-52 Age-related macular degeneration (geographic atrophy); BRCA cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg26384229 chr12:38710491 ALG10B 0.52 13.6 0.47 3.6e-37 Morning vs. evening chronotype; BRCA cis rs881375 0.702 rs3761847 chr9:123690239 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 8.42 0.32 2.5e-16 Rheumatoid arthritis; BRCA cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11890956 chr21:40555474 PSMG1 -0.63 -14.12 -0.49 1.33e-39 Menarche (age at onset); BRCA cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg05347473 chr6:146136440 FBXO30 -0.42 -8.19 -0.31 1.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg14004847 chr7:1930337 MAD1L1 -0.47 -8.87 -0.33 7.53e-18 Bipolar disorder and schizophrenia; BRCA cis rs6545883 0.894 rs6739427 chr2:61452879 T/C cg15711740 chr2:61764176 XPO1 0.51 13.01 0.46 1.71e-34 Tuberculosis; BRCA cis rs6740322 0.748 rs6544636 chr2:43487486 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.8 -15.38 -0.52 1.18e-45 Coronary artery disease; BRCA cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg26384229 chr12:38710491 ALG10B 0.76 17.07 0.56 4.41e-54 Morning vs. evening chronotype; BRCA cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg11941060 chr3:133502564 NA -0.47 -11.47 -0.41 8.18e-28 Iron status biomarkers; BRCA cis rs2797160 1.000 rs1832979 chr6:125997436 A/G cg05901451 chr6:126070800 HEY2 -0.42 -10.1 -0.37 2.39e-22 Endometrial cancer; BRCA cis rs8017423 0.647 rs1958345 chr14:90823770 T/C cg04374321 chr14:90722782 PSMC1 -0.49 -11.86 -0.42 1.75e-29 Mortality in heart failure; BRCA cis rs4891159 0.790 rs17059325 chr18:74119567 A/C cg24786174 chr18:74118243 ZNF516 -0.73 -17.79 -0.58 8.28e-58 Longevity; BRCA cis rs295140 0.507 rs1369842 chr2:201108987 C/A cg23649088 chr2:200775458 C2orf69 -0.39 -8.37 -0.31 3.65e-16 QT interval; BRCA trans rs1941687 0.563 rs1565784 chr18:31358491 G/T cg27147174 chr7:100797783 AP1S1 0.39 7.93 0.3 9.56e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7264396 0.635 rs6060710 chr20:34536055 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.75 -0.5 1.31e-42 Total cholesterol levels; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg05552183 chr6:42928497 GNMT 0.8 19.33 0.61 6.54e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg11663144 chr21:46675770 NA -0.61 -14.31 -0.49 1.63e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 0.882 rs10422667 chr19:37937876 T/C cg18154014 chr19:37997991 ZNF793 0.62 11.64 0.42 1.49e-28 Coronary artery calcification; BRCA cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg20701182 chr2:24300061 SF3B14 0.66 9.66 0.36 1.04e-20 Lymphocyte counts; BRCA cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg19539972 chr4:7069911 GRPEL1 0.69 16.87 0.56 4.3e-53 Monocyte percentage of white cells; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.47 0.32 1.64e-16 Platelet count; BRCA trans rs1459104 0.925 rs35535067 chr11:54995548 G/T cg15704280 chr7:45808275 SEPT13 0.59 7.81 0.3 2.27e-14 Body mass index; BRCA cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg05283184 chr6:79620031 NA -0.43 -11.04 -0.4 4.58e-26 Intelligence (multi-trait analysis); BRCA cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.22 -0.37 8.46e-23 Psoriasis; BRCA trans rs11098499 0.863 rs13149407 chr4:120437825 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.13 0.31 2.2e-15 Corneal astigmatism; BRCA cis rs752010 0.967 rs752011 chr1:42092929 C/T cg06885757 chr1:42089581 HIVEP3 0.27 9.5 0.35 4.05e-20 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg13319975 chr6:146136371 FBXO30 -0.61 -13.71 -0.48 1.09e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg16362232 chr11:430036 ANO9 0.5 8.03 0.3 4.82e-15 Body mass index; BRCA cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg11266682 chr4:10021025 SLC2A9 -0.37 -9.55 -0.35 2.75e-20 Bone mineral density; BRCA cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.63 14.22 0.49 4.48e-40 Age-related macular degeneration (geographic atrophy); BRCA cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg05665937 chr4:1216051 CTBP1 -0.43 -8.59 -0.32 6.41e-17 Obesity-related traits; BRCA cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg03146154 chr1:46216737 IPP 0.5 10.59 0.39 2.87e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11105298 0.891 rs4842664 chr12:89938030 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.52 -0.35 3.58e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg17420585 chr12:42539391 GXYLT1 -0.41 -8.54 -0.32 9.52e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.59 0.39 3.01e-24 Motion sickness; BRCA cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.3 -0.31 6.27e-16 Total body bone mineral density; BRCA cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg04450456 chr4:17643702 FAM184B 0.41 12.33 0.44 1.67e-31 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg21724239 chr8:58056113 NA 0.59 9.54 0.35 2.88e-20 Developmental language disorder (linguistic errors); BRCA cis rs9462846 0.881 rs34498470 chr6:42879551 C/T cg02353165 chr6:42928485 GNMT 0.5 9.17 0.34 6.2800000000000005e-19 Blood protein levels; BRCA cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg05025164 chr4:1340916 KIAA1530 0.39 8.66 0.32 3.81e-17 Longevity; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg18402987 chr7:1209562 NA 0.61 12.76 0.45 2.24e-33 Longevity;Endometriosis; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg13047869 chr3:10149882 C3orf24 0.55 10.19 0.37 1.03e-22 Alzheimer's disease; BRCA cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs6088590 0.931 rs6088617 chr20:33408036 G/A cg24642439 chr20:33292090 TP53INP2 0.71 16.27 0.54 4.9e-50 Coronary artery disease; BRCA cis rs867371 1.000 rs8041924 chr15:82473661 A/T cg00614314 chr15:82944287 LOC80154 0.43 9.09 0.34 1.19e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg04518342 chr5:131593106 PDLIM4 -0.43 -10.86 -0.39 2.46e-25 Acylcarnitine levels; BRCA cis rs877282 0.891 rs12357999 chr10:796468 A/C cg17470449 chr10:769945 NA 0.51 8.71 0.33 2.54e-17 Uric acid levels; BRCA trans rs11098499 0.954 rs28572238 chr4:120316686 T/G cg25214090 chr10:38739885 LOC399744 0.52 11.94 0.43 8.18e-30 Corneal astigmatism; BRCA cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg08999081 chr20:33150536 PIGU -0.33 -8.54 -0.32 9.89e-17 Glomerular filtration rate (creatinine); BRCA cis rs9811920 0.535 rs704574 chr3:99483773 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.41 9.67 0.36 1e-20 Axial length; BRCA cis rs1568889 0.838 rs3812738 chr11:28129982 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 20.7 0.63 3.05e-73 Bipolar disorder; BRCA cis rs9649465 0.967 rs13244694 chr7:123329879 T/C cg04330084 chr7:123175371 IQUB -0.31 -8.39 -0.32 3.01e-16 Migraine; BRCA trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.52 -16.08 -0.54 4.3e-49 Intelligence (multi-trait analysis); BRCA cis rs12474201 0.928 rs13429704 chr2:46960329 G/T cg06386533 chr2:46925753 SOCS5 0.75 16.45 0.55 6.13e-51 Height; BRCA cis rs2637030 0.559 rs31303 chr5:52942197 C/T cg06476337 chr5:52856530 NDUFS4 -0.37 -8.55 -0.32 9.11e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs17270561 0.609 rs12663099 chr6:25739518 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.8 0.33 1.28e-17 Iron status biomarkers; BRCA cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg22117172 chr7:91764530 CYP51A1 0.24 7.99 0.3 6.32e-15 Breast cancer; BRCA trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg08975724 chr8:8085496 FLJ10661 0.43 8.5 0.32 1.38e-16 Retinal vascular caliber; BRCA cis rs4363385 0.655 rs11205163 chr1:152983677 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -8.98 -0.33 3.08e-18 Inflammatory skin disease; BRCA cis rs175714 0.845 rs175702 chr14:75971133 G/T cg01624173 chr14:75981868 NA -0.34 -9.26 -0.34 3.02e-19 Lymphocyte counts; BRCA cis rs10752881 0.839 rs2093983 chr1:183094210 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Colorectal cancer; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg05552183 chr6:42928497 GNMT -0.52 -11.78 -0.42 4.02e-29 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs67460515 0.563 rs68166680 chr3:160829735 T/A cg17135325 chr3:160939158 NMD3 0.42 7.97 0.3 7.24e-15 Parkinson's disease; BRCA cis rs2625529 0.824 rs7172309 chr15:72384483 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.46 -0.57 4.05e-56 Red blood cell count; BRCA cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg03517284 chr6:25882590 NA -0.54 -10.98 -0.4 8.43e-26 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg21475434 chr5:93447410 FAM172A 0.67 8.72 0.33 2.48e-17 Diabetic retinopathy; BRCA cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.53 -0.32 1.09e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg13114125 chr14:105738426 BRF1 -0.49 -10.27 -0.38 5.04e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs7582180 0.629 rs4851297 chr2:100949571 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.7 0.42 8.61e-29 Intelligence (multi-trait analysis); BRCA cis rs16854884 0.609 rs9872126 chr3:143683851 G/A cg06585982 chr3:143692056 C3orf58 0.49 10.55 0.39 4.44e-24 Economic and political preferences (feminism/equality); BRCA cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg06108461 chr20:60628389 TAF4 -0.99 -22.15 -0.66 4.18e-81 Body mass index; BRCA cis rs311392 0.554 rs311387 chr8:55101623 A/G cg11783602 chr8:55087084 NA 0.28 8.04 0.3 4.44e-15 Pelvic organ prolapse (moderate/severe); BRCA cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg01579765 chr21:45077557 HSF2BP -0.43 -11.58 -0.42 2.83e-28 Mean corpuscular volume; BRCA cis rs701145 0.585 rs1713810 chr3:153876826 C/T cg17054900 chr3:154042577 DHX36 -0.44 -8.28 -0.31 7.39e-16 Coronary artery disease; BRCA cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg19847866 chr10:1019161 NA 0.42 9.23 0.34 3.91e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg09184832 chr6:79620586 NA -0.5 -10.89 -0.4 1.9e-25 Intelligence (multi-trait analysis); BRCA cis rs3739998 0.686 rs2505084 chr10:30335520 C/T cg12786570 chr10:30316432 KIAA1462 -0.37 -8.32 -0.31 5.48e-16 Coronary heart disease; BRCA cis rs3008870 0.920 rs975452 chr1:67480190 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 21.16 0.64 9.69e-76 Lymphocyte percentage of white cells; BRCA cis rs1018836 0.923 rs34126139 chr8:91572045 T/G cg16814680 chr8:91681699 NA -0.59 -12.56 -0.44 1.77e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg18110333 chr6:292329 DUSP22 0.59 12.52 0.44 2.63e-32 Menopause (age at onset); BRCA cis rs6546550 0.901 rs6725425 chr2:70150674 T/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.84e-28 Prevalent atrial fibrillation; BRCA cis rs3806843 0.676 rs2245640 chr5:140029958 A/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.72 0.39 9.23e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.31e-54 Bladder cancer; BRCA cis rs9790314 0.967 rs336541 chr3:161056698 A/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.04 -0.49 3.32e-39 Morning vs. evening chronotype; BRCA cis rs1593 0.641 rs28690003 chr4:187224562 G/A cg14349977 chr4:187219430 NA 0.64 11.05 0.4 4.41e-26 Activated partial thromboplastin time; BRCA cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg09184832 chr6:79620586 NA -0.51 -11.17 -0.4 1.43e-26 Intelligence (multi-trait analysis); BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03352830 chr11:487213 PTDSS2 0.87 13.62 0.47 2.74e-37 Body mass index; BRCA cis rs9814567 1.000 rs2370578 chr3:134199612 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.46 -0.61 1.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2070997 0.607 rs7856783 chr9:133713507 T/C cg11464064 chr9:133710261 ABL1 0.55 10.12 0.37 2e-22 Response to amphetamines; BRCA cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs1153858 1.000 rs12591058 chr15:45640172 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.9 0.43 1.19e-29 Homoarginine levels; BRCA cis rs3733585 0.699 rs1122142 chr4:9947548 G/C cg00071950 chr4:10020882 SLC2A9 -0.47 -10.97 -0.4 9.11e-26 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.33 9.06 0.34 1.56e-18 Intelligence (multi-trait analysis); BRCA cis rs9858542 0.953 rs11719996 chr3:49525958 T/C cg03060546 chr3:49711283 APEH -0.53 -10.62 -0.39 2.21e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg11764359 chr7:65958608 NA 0.8 19.37 0.61 4.34e-66 Aortic root size; BRCA cis rs113835537 0.529 rs17496250 chr11:66270774 C/G cg24851651 chr11:66362959 CCS 0.51 8.83 0.33 9.85e-18 Airway imaging phenotypes; BRCA cis rs6763687 0.893 rs12633493 chr3:171778354 C/T cg16233210 chr3:171778391 FNDC3B 0.5 12.04 0.43 3.18e-30 Red cell distribution width; BRCA cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg16325326 chr1:53192061 ZYG11B -0.57 -12.02 -0.43 3.81e-30 Monocyte count; BRCA cis rs9486719 1.000 rs4262195 chr6:96929475 T/C cg06623918 chr6:96969491 KIAA0776 -0.73 -13.15 -0.46 3.89e-35 Migraine;Coronary artery disease; BRCA cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.19 -0.4 1.11e-26 Colorectal cancer; BRCA cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg24977027 chr2:88469347 THNSL2 0.56 9.54 0.35 3.01e-20 Plasma clusterin levels; BRCA cis rs6089584 0.927 rs2296081 chr20:60572663 G/T cg13770153 chr20:60521292 NA -0.44 -10.72 -0.39 9.44e-25 Body mass index; BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26314531 chr2:26401878 FAM59B 0.75 10.57 0.39 3.45e-24 Gut microbiome composition (summer); BRCA cis rs965469 0.817 rs6037582 chr20:3351696 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.86 -0.33 7.9e-18 IFN-related cytopenia; BRCA cis rs4363385 0.740 rs4845518 chr1:153003903 A/G cg24667326 chr1:152973720 SPRR3 -0.31 -8.36 -0.31 3.86e-16 Inflammatory skin disease; BRCA cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg23422044 chr7:1970798 MAD1L1 -0.56 -9.55 -0.35 2.7e-20 Neuroticism; BRCA cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg14558114 chr2:88469736 THNSL2 -0.59 -8.39 -0.31 3.17e-16 Plasma clusterin levels; BRCA cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg01475735 chr3:40494733 NA -0.47 -9.68 -0.36 8.79e-21 Renal cell carcinoma; BRCA cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg15131784 chr3:139108705 COPB2 0.36 8.99 0.34 2.68e-18 Obesity-related traits; BRCA cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg06484146 chr7:12443880 VWDE -0.64 -9.95 -0.37 8.95e-22 Coronary artery disease; BRCA cis rs56399783 0.901 rs757788 chr7:2836433 A/G cg19731401 chr7:2775893 GNA12 0.49 8.14 0.31 2.1e-15 Childhood ear infection; BRCA cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg14863265 chr7:2801509 GNA12 -0.43 -9.8 -0.36 3.25e-21 Height; BRCA cis rs7917772 0.582 rs7907760 chr10:104345197 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg22875332 chr1:76189707 ACADM 0.66 15.64 0.53 6.25e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.7 0.5 2.41e-42 Motion sickness; BRCA cis rs11098499 0.754 rs28652763 chr4:120242312 C/T cg09307838 chr4:120376055 NA 0.64 13.93 0.48 1.02e-38 Corneal astigmatism; BRCA cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg26874164 chr19:58962979 ZNF324B 0.44 9.39 0.35 1.08e-19 Uric acid clearance; BRCA cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg26597838 chr10:835615 NA 0.97 17.04 0.56 6.2e-54 Eosinophil percentage of granulocytes; BRCA cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs473651 0.503 rs515342 chr2:239367296 A/G cg18131467 chr2:239335373 ASB1 -0.8 -15.79 -0.53 1.17e-47 Multiple system atrophy; BRCA cis rs7172677 0.737 rs12442410 chr15:75437510 G/A cg14664628 chr15:75095509 CSK -0.39 -8.05 -0.3 3.93e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg04518342 chr5:131593106 PDLIM4 0.37 9.26 0.34 2.98e-19 Breast cancer; BRCA cis rs7172677 0.737 rs12442410 chr15:75437510 G/A cg10253484 chr15:75165896 SCAMP2 -0.45 -8.31 -0.31 5.6e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -13.15 -0.46 4.08e-35 Lymphocyte counts; BRCA cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.94 0.4 1.2e-25 Rheumatoid arthritis; BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg14820908 chr5:178986412 RUFY1 0.36 9.01 0.34 2.36e-18 Lung cancer; BRCA cis rs7851660 0.967 rs3758248 chr9:100614601 G/A cg13688889 chr9:100608707 NA -0.36 -8.72 -0.33 2.42e-17 Strep throat; BRCA cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg04317338 chr11:64019027 PLCB3 0.54 9.41 0.35 8.75e-20 Mean platelet volume; BRCA cis rs870825 0.616 rs7660064 chr4:185617529 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.18e-56 Blood protein levels; BRCA cis rs2637266 0.935 rs2583055 chr10:78400029 C/T cg18941641 chr10:78392320 NA 0.36 8.27 0.31 7.61e-16 Pulmonary function; BRCA cis rs7267979 0.844 rs6132824 chr20:25238173 T/C cg08601574 chr20:25228251 PYGB 0.4 9.61 0.36 1.62e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg00677455 chr12:58241039 CTDSP2 -0.35 -7.89 -0.3 1.34e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs7647973 0.626 rs62262672 chr3:49655927 T/A cg03060546 chr3:49711283 APEH -0.57 -8.51 -0.32 1.25e-16 Menarche (age at onset); BRCA cis rs13064411 0.627 rs28710051 chr3:113143531 G/A cg18753928 chr3:113234510 CCDC52 -0.5 -9.42 -0.35 8.42e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs10504073 0.584 rs4873092 chr8:49974053 T/C cg00325661 chr8:49890786 NA 0.44 12.86 0.45 8.36e-34 Blood metabolite ratios; BRCA cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11890956 chr21:40555474 PSMG1 1.04 29.21 0.76 9.04e-120 Cognitive function; BRCA cis rs13190036 0.551 rs7710269 chr5:176614529 G/A cg06733329 chr5:176740039 MXD3 0.37 8.02 0.3 5.22e-15 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs9296092 0.538 rs78061112 chr6:33526587 T/G cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.65 0.42 1.47e-28 Mean platelet volume; BRCA cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs4820294 0.669 rs9622678 chr22:38057338 A/G cg21798802 chr22:38057573 PDXP 0.3 8.39 0.31 3.13e-16 Fat distribution (HIV); BRCA cis rs57590327 0.555 rs3755713 chr3:81811224 A/G cg07356753 chr3:81810745 GBE1 -0.46 -10.61 -0.39 2.42e-24 Extraversion; BRCA cis rs4076764 1.000 rs12740984 chr1:163422151 A/G cg06092702 chr1:163392909 NA 0.33 8.8 0.33 1.27e-17 Motion sickness; BRCA cis rs636291 0.517 rs12565133 chr1:10544988 A/C cg07384165 chr1:10488281 NA 0.4 8.51 0.32 1.2e-16 Prostate cancer; BRCA trans rs4718428 0.705 rs62465692 chr7:66295745 T/C cg18876405 chr7:65276391 NA 0.44 8.51 0.32 1.19e-16 Corneal structure; BRCA cis rs1568889 1.000 rs12804198 chr11:28143114 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 13.49 0.47 1.18e-36 Bipolar disorder; BRCA trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.24 -0.34 3.63e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4363385 0.818 rs368912 chr1:153016204 C/G cg24667326 chr1:152973720 SPRR3 -0.32 -8.83 -0.33 1.04e-17 Inflammatory skin disease; BRCA cis rs72792276 1.000 rs72794361 chr5:127435188 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.63 10.68 0.39 1.35e-24 Red cell distribution width; BRCA trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.74 0.36 5.53e-21 Morning vs. evening chronotype; BRCA cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg03433033 chr1:76189801 ACADM 0.88 23.77 0.68 5.96e-90 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg21132104 chr15:45694354 SPATA5L1 0.72 16.11 0.54 3.11e-49 Homoarginine levels; BRCA cis rs7246657 0.722 rs2909102 chr19:38167364 C/T cg23950597 chr19:37808831 NA 0.51 8.7 0.33 2.71e-17 Coronary artery calcification; BRCA cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg14926445 chr8:58193284 C8orf71 -0.46 -8.73 -0.33 2.2e-17 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs2562456 0.876 rs11085468 chr19:21751889 C/T cg25042112 chr7:64838748 ZNF92 -0.45 -8.52 -0.32 1.18e-16 Pain; BRCA cis rs78456975 1.000 rs13422995 chr2:1553554 C/A cg12573674 chr2:1569213 NA -0.49 -9.34 -0.35 1.58e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg08132940 chr7:1081526 C7orf50 -0.46 -8.33 -0.31 5e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg17330251 chr7:94953956 PON1 -0.42 -8.58 -0.32 7.32e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs11098499 0.604 rs12642411 chr4:120580525 T/C cg25214090 chr10:38739885 LOC399744 0.53 10.87 0.4 2.23e-25 Corneal astigmatism; BRCA cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.33 0.57 1.83e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg11742103 chr11:62369870 EML3;MTA2 0.54 11.44 0.41 1.03e-27 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.01e-40 Motion sickness; BRCA cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg22974920 chr21:40686053 BRWD1 -0.4 -8.95 -0.33 3.84e-18 Cognitive function; BRCA cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.52 -0.32 1.17e-16 Monocyte percentage of white cells; BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg23285459 chr7:2802560 GNA12 -0.32 -8.34 -0.31 4.68e-16 Height; BRCA cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg11764359 chr7:65958608 NA 0.74 16.57 0.55 1.44e-51 Aortic root size; BRCA trans rs10880689 1 rs10880689 chr12:37930102 A/G cg06521331 chr12:34319734 NA -0.54 -10.29 -0.38 4.42e-23 Resting heart rate; BRCA cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg23029597 chr12:123009494 RSRC2 -0.61 -11.81 -0.42 3e-29 Body mass index; BRCA cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg00530320 chr1:46809349 NSUN4 -0.48 -9.68 -0.36 9.08e-21 Menopause (age at onset); BRCA cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg01448562 chr3:133502909 NA -0.39 -8.93 -0.33 4.53e-18 Iron status biomarkers; BRCA cis rs11955398 0.585 rs1816861 chr5:60011676 T/A cg02684056 chr5:59996105 DEPDC1B -0.37 -9.04 -0.34 1.9e-18 Intelligence (multi-trait analysis); BRCA cis rs7178424 0.935 rs17271438 chr15:62381065 C/A cg00456672 chr15:62358751 C2CD4A -0.34 -8.05 -0.3 4.14e-15 Height; BRCA cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs290268 0.669 rs10448310 chr9:93556174 A/G cg02608019 chr9:93564028 SYK 0.49 10.99 0.4 7.69e-26 Platelet count; BRCA cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.75 15.47 0.52 4.41e-46 Smoking behavior; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg03188948 chr7:1209495 NA 0.45 8.39 0.31 3.17e-16 Longevity;Endometriosis; BRCA cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg04553112 chr3:125709451 NA -0.56 -8.5 -0.32 1.34e-16 Blood pressure (smoking interaction); BRCA trans rs61931739 0.517 rs9668303 chr12:34366701 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.51 0.55 2.99e-51 Morning vs. evening chronotype; BRCA cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg27170947 chr2:26402098 FAM59B -0.61 -10.11 -0.37 2.17e-22 Gut microbiome composition (summer); BRCA cis rs2731664 0.792 rs335435 chr5:176867943 A/G cg23176889 chr5:176863531 GRK6 -0.61 -16.35 -0.54 1.95e-50 Intelligence (multi-trait analysis); BRCA cis rs7647973 0.626 rs4855833 chr3:49657441 A/G cg07636037 chr3:49044803 WDR6 0.51 8.57 0.32 7.96e-17 Menarche (age at onset); BRCA cis rs9467773 0.620 rs9295701 chr6:26627508 T/C cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.5e-30 Intelligence (multi-trait analysis); BRCA cis rs4891159 0.790 rs1787448 chr18:74113179 T/C cg24786174 chr18:74118243 ZNF516 0.74 18.65 0.59 2.67e-62 Longevity; BRCA cis rs3772130 0.962 rs1318472 chr3:121556899 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.72 0.39 8.89e-25 Cognitive performance; BRCA cis rs1008375 0.966 rs10939736 chr4:17581617 T/A cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg15541040 chr2:3486749 NA -0.42 -8.88 -0.33 6.58e-18 Neurofibrillary tangles; BRCA cis rs7833986 1.000 rs34037954 chr8:57096841 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.19 0.31 1.46e-15 Height; BRCA cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg17366294 chr4:99064904 C4orf37 0.53 11.6 0.42 2.24e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg09455208 chr3:40491958 NA 0.47 11.63 0.42 1.73e-28 Renal cell carcinoma; BRCA cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg24450063 chr1:156163899 SLC25A44 1.11 35.2 0.81 9.83e-152 Testicular germ cell tumor; BRCA cis rs3125734 0.633 rs1368157 chr10:64001114 T/C cg19640130 chr10:64028056 RTKN2 -0.31 -8.68 -0.32 3.26e-17 Rheumatoid arthritis; BRCA cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg26384229 chr12:38710491 ALG10B 0.78 18.29 0.59 2.17e-60 Drug-induced liver injury (flucloxacillin); BRCA cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg12573674 chr2:1569213 NA 0.47 9.1 0.34 1.14e-18 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg07148914 chr20:33460835 GGT7 0.38 8.62 0.32 5.1e-17 Height; BRCA cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg14983838 chr19:29218262 NA 0.54 10.08 0.37 2.78e-22 Methadone dose in opioid dependence; BRCA cis rs13190036 1.000 rs34446750 chr5:176595080 A/G cg06733329 chr5:176740039 MXD3 0.46 8.3 0.31 6.01e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs11758351 0.866 rs55815656 chr6:26207303 G/A cg01420254 chr6:26195488 NA 0.53 8.54 0.32 9.95e-17 Gout;Renal underexcretion gout; BRCA cis rs1371614 0.592 rs12613534 chr2:27138594 C/A cg12368169 chr2:27073192 DPYSL5 -0.29 -8.74 -0.33 2.03e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs172166 0.769 rs149965 chr6:28018689 T/A cg10876282 chr6:28092338 ZSCAN16 0.4 7.84 0.3 1.9e-14 Cardiac Troponin-T levels; BRCA cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg23029597 chr12:123009494 RSRC2 -0.48 -9.57 -0.35 2.28e-20 Body mass index; BRCA cis rs7267979 1.000 rs1888997 chr20:25298988 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.65 -0.32 4.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1949733 1.000 rs2631740 chr4:8484106 C/A cg11789530 chr4:8429930 ACOX3 -0.68 -17.62 -0.57 6.51e-57 Response to antineoplastic agents; BRCA cis rs11231017 0.507 rs2178260 chr11:62069365 C/T cg23876832 chr11:62092739 NA 0.33 8.44 0.32 2.19e-16 HIV-1 viral setpoint; BRCA cis rs2625529 0.652 rs2957736 chr15:72265344 A/G cg16672083 chr15:72433130 SENP8 0.68 16.19 0.54 1.2e-49 Red blood cell count; BRCA cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.42 -0.38 1.4e-23 Personality dimensions; BRCA cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg18904891 chr8:8559673 CLDN23 0.61 12.07 0.43 2.36e-30 Obesity-related traits; BRCA cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg25019033 chr10:957182 NA -0.42 -8.05 -0.3 4.04e-15 Eosinophil percentage of granulocytes; BRCA cis rs7177699 0.557 rs7403593 chr15:79111962 A/G cg00540400 chr15:79124168 NA -0.28 -7.88 -0.3 1.39e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs12347191 0.500 rs925486 chr9:100619733 C/T cg13688889 chr9:100608707 NA -0.49 -9.92 -0.37 1.19e-21 Orofacial clefts; BRCA cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.77 -0.36 4.17e-21 Developmental language disorder (linguistic errors); BRCA cis rs858239 0.932 rs199355 chr7:23296533 C/T cg23682824 chr7:23144976 KLHL7 0.32 8.25 0.31 8.72e-16 Cerebrospinal fluid biomarker levels; BRCA trans rs35110281 0.592 rs6417729 chr21:44967202 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.56 0.39 3.82e-24 Mean corpuscular volume; BRCA cis rs2346177 0.554 rs36006825 chr2:46708945 G/T cg02822958 chr2:46747628 ATP6V1E2 0.58 11.16 0.4 1.52e-26 HDL cholesterol; BRCA cis rs7824557 0.767 rs10104728 chr8:11171300 A/G cg21775007 chr8:11205619 TDH 0.62 11.99 0.43 5.15e-30 Retinal vascular caliber; BRCA cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.52 -11.59 -0.42 2.51e-28 Personality dimensions; BRCA cis rs6496044 0.526 rs4291869 chr15:86054523 G/A cg10818794 chr15:86012489 AKAP13 -0.32 -8.69 -0.33 3.05e-17 Interstitial lung disease; BRCA cis rs9463078 0.753 rs1980265 chr6:44928868 C/A cg25276700 chr6:44698697 NA -0.37 -8.56 -0.32 8.58e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7737355 0.947 rs3776028 chr5:130789750 G/A cg06307176 chr5:131281290 NA -0.53 -10.58 -0.39 3.37e-24 Life satisfaction; BRCA cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.22 0.37 8.56e-23 Calcium levels; BRCA cis rs7903847 0.620 rs11189168 chr10:99125769 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.26 -0.31 8.57e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs1538970 0.924 rs1007858 chr1:45912005 C/T cg05343316 chr1:45956843 TESK2 0.62 12.58 0.45 1.39e-32 Platelet count; BRCA cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.19e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg21747090 chr2:27597821 SNX17 -0.45 -9.67 -0.36 9.89e-21 Total body bone mineral density; BRCA cis rs9486719 1.000 rs2472882 chr6:96863474 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg25319279 chr11:5960081 NA -0.4 -7.9 -0.3 1.24e-14 DNA methylation (variation); BRCA cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9287719 0.839 rs12692415 chr2:10745474 A/G cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -9.79 -0.36 3.38e-21 Schizophrenia; BRCA cis rs1348850 0.526 rs9288003 chr2:178446572 T/G cg27490568 chr2:178487706 NA 0.42 7.85 0.3 1.74e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1788820 0.917 rs4800489 chr18:21125942 A/G cg14672496 chr18:21087552 C18orf8 0.34 8.34 0.31 4.72e-16 Body mass index; BRCA cis rs4808199 0.895 rs10419672 chr19:19471241 T/C cg01262667 chr19:19385393 TM6SF2 0.38 7.98 0.3 6.56e-15 Nonalcoholic fatty liver disease; BRCA cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs870825 0.655 rs28726376 chr4:185638954 A/G cg04058563 chr4:185651563 MLF1IP 0.77 17.27 0.56 3.85e-55 Blood protein levels; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg22963979 chr7:1858916 MAD1L1 -0.37 -7.82 -0.3 2.23e-14 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.16 0.31 1.79e-15 Platelet count; BRCA cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.626 rs1011372 chr7:91509867 T/C cg17063962 chr7:91808500 NA -0.55 -12.65 -0.45 6.88e-33 Breast cancer; BRCA cis rs6546550 0.869 rs6720498 chr2:70124805 T/C cg02498382 chr2:70120550 SNRNP27 -0.54 -11.63 -0.42 1.76e-28 Prevalent atrial fibrillation; BRCA cis rs68170813 0.559 rs78610616 chr7:106951369 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.52 -0.32 1.16e-16 Coronary artery disease; BRCA cis rs2249625 0.523 rs2463702 chr6:72853778 A/G cg18830697 chr6:72922368 RIMS1 0.5 11.29 0.41 4.52e-27 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg24549020 chr5:56110836 MAP3K1 0.64 12.87 0.45 7.13e-34 Initial pursuit acceleration; BRCA cis rs3857536 0.740 rs6455080 chr6:66887413 T/A cg07460842 chr6:66804631 NA -0.48 -9.27 -0.34 2.78e-19 Blood trace element (Cu levels); BRCA cis rs11677370 0.561 rs12986995 chr2:3826965 G/A cg17052675 chr2:3827356 NA -0.6 -15.32 -0.52 2.33e-45 Type 2 diabetes; BRCA cis rs11229555 0.645 rs56228632 chr11:58187444 A/G cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.05e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs11792861 0.962 rs3750454 chr9:111801325 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.45 -8.44 -0.32 2.15e-16 Menarche (age at onset); BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00149659 chr3:10157352 C3orf10 0.77 13.29 0.47 9.06e-36 Alzheimer's disease; BRCA cis rs6977660 0.714 rs10228783 chr7:19789290 C/T cg05791153 chr7:19748676 TWISTNB 0.58 10.55 0.39 4.25e-24 Thyroid stimulating hormone; BRCA cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg05472934 chr7:22766657 IL6 0.59 15.1 0.51 2.92e-44 Cerebrospinal fluid clusterin levels in APOEe4- carriers; BRCA cis rs16854884 0.657 rs12107291 chr3:143739547 T/C cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA cis rs8062405 0.755 rs12447461 chr16:28582941 C/A cg16576597 chr16:28551801 NUPR1 0.33 9.2 0.34 4.87e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.05 -0.37 3.72e-22 IgG glycosylation; BRCA cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 8.62 0.32 5.17e-17 Mean platelet volume; BRCA cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg23788917 chr6:8435910 SLC35B3 0.49 10.69 0.39 1.17e-24 Motion sickness; BRCA cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.36 8.03 0.3 4.73e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3768617 0.811 rs4350171 chr1:182982148 C/T ch.1.3577855R chr1:183094577 LAMC1 0.45 9.81 0.36 2.84e-21 Fuchs's corneal dystrophy; BRCA cis rs6546550 0.935 rs1377995 chr2:70064155 C/G cg02498382 chr2:70120550 SNRNP27 -0.5 -10.48 -0.38 7.82e-24 Prevalent atrial fibrillation; BRCA cis rs3796352 0.892 rs35076015 chr3:53026366 C/T cg07884673 chr3:53033167 SFMBT1 0.86 9.98 0.37 6.83e-22 Immune reponse to smallpox (secreted IL-2); BRCA cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg16414030 chr3:133502952 NA -0.47 -11.11 -0.4 2.44e-26 Iron status biomarkers; BRCA cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg05347473 chr6:146136440 FBXO30 0.41 7.97 0.3 7.08e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg13298116 chr11:62369859 EML3;MTA2 0.59 13.92 0.48 1.17e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs589448 0.867 rs623853 chr12:69753830 G/A cg22834771 chr12:69754056 YEATS4 -0.43 -10.63 -0.39 2.04e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs977987 0.806 rs1109342 chr16:75445675 A/G cg03315344 chr16:75512273 CHST6 -0.51 -11.95 -0.43 7.88e-30 Dupuytren's disease; BRCA cis rs1348850 0.554 rs1374438 chr2:178376684 A/G cg27490568 chr2:178487706 NA 0.49 8.21 0.31 1.26e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6545883 0.860 rs13023037 chr2:61620989 C/T cg15711740 chr2:61764176 XPO1 0.56 14.42 0.5 5.05e-41 Tuberculosis; BRCA cis rs9487051 0.872 rs7772602 chr6:109608661 C/G cg21918786 chr6:109611834 NA 0.48 14.01 0.48 4.6e-39 Reticulocyte fraction of red cells; BRCA cis rs7103648 0.864 rs10769264 chr11:47423340 C/T cg03711944 chr11:47377212 SPI1 -0.42 -11.54 -0.42 3.99e-28 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs4363385 0.747 rs10399896 chr1:152975083 T/A cg21543102 chr1:152974771 SPRR3 -0.3 -8.31 -0.31 5.88e-16 Inflammatory skin disease; BRCA cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs398036 chr20:25439850 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.97 0.33 3.29e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs72781680 0.716 rs2551334 chr2:24000396 G/A cg08917208 chr2:24149416 ATAD2B 0.58 9.63 0.36 1.43e-20 Lymphocyte counts; BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg13866156 chr1:1669148 SLC35E2 0.4 8.71 0.33 2.52e-17 Body mass index; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.19 -0.34 5.64e-19 Bipolar disorder and schizophrenia; BRCA cis rs3008870 1.000 rs2985817 chr1:67398607 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.99 22.65 0.67 8.12e-84 Lymphocyte percentage of white cells; BRCA cis rs6586163 0.546 rs12359362 chr10:90753145 G/C cg03111039 chr10:90751583 FAS;ACTA2 0.57 13.21 0.46 2.16e-35 Chronic lymphocytic leukemia; BRCA cis rs1801251 0.963 rs35395584 chr2:233573698 G/C cg08000102 chr2:233561755 GIGYF2 0.62 13.52 0.47 8.41e-37 Coronary artery disease; BRCA cis rs7149337 0.805 rs3007069 chr14:51597392 G/A cg23942311 chr14:51606299 NA 0.45 12.86 0.45 8.31e-34 Cancer; BRCA cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg00999904 chr2:3704751 ALLC 0.39 7.85 0.3 1.72e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg17971929 chr21:40555470 PSMG1 0.78 17.91 0.58 2.02e-58 Cognitive function; BRCA cis rs1691799 0.899 rs1168293 chr12:66733904 G/A cg16791601 chr12:66731901 HELB -0.62 -16.43 -0.55 6.98e-51 White blood cell count (basophil); BRCA cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg09469691 chr10:81107165 PPIF 0.45 9.75 0.36 4.76e-21 Height; BRCA cis rs4595586 0.545 rs12809435 chr12:39404341 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.52 -0.35 3.37e-20 Morning vs. evening chronotype; BRCA cis rs9399135 0.967 rs6908512 chr6:135367757 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.46e-31 Red blood cell count; BRCA cis rs514406 0.858 rs574853 chr1:53310959 A/T cg25767906 chr1:53392781 SCP2 -0.39 -8.79 -0.33 1.4e-17 Monocyte count; BRCA cis rs11628318 0.853 rs7140280 chr14:103026991 C/T cg01864069 chr14:103024347 NA -0.42 -8.18 -0.31 1.59e-15 Platelet count; BRCA cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg24110177 chr3:50126178 RBM5 0.52 14.76 0.5 1.21e-42 Body mass index; BRCA cis rs2806561 0.704 rs588387 chr1:23523689 A/G cg12483005 chr1:23474871 LUZP1 0.48 10.46 0.38 9.57e-24 Height; BRCA cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg00083206 chr6:110721305 DDO -0.4 -9.77 -0.36 4.22e-21 Platelet distribution width; BRCA cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.52 0.41 4.96e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg20933634 chr6:27740509 NA 0.45 9.11 0.34 1.07e-18 Parkinson's disease; BRCA cis rs11971779 0.680 rs6962186 chr7:139034806 T/C cg07862535 chr7:139043722 LUC7L2 0.39 10.42 0.38 1.32e-23 Diisocyanate-induced asthma; BRCA cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.29 0.56 3.29e-55 Bladder cancer; BRCA cis rs7809950 1.000 rs2057837 chr7:107222725 C/G cg23024343 chr7:107201750 COG5 0.4 9.1 0.34 1.1e-18 Coronary artery disease; BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg20607798 chr8:58055168 NA 0.6 9.1 0.34 1.1e-18 Developmental language disorder (linguistic errors); BRCA cis rs4481887 0.927 rs7519334 chr1:248472076 C/T cg00666640 chr1:248458726 OR2T12 0.31 8.64 0.32 4.64e-17 Common traits (Other); BRCA cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.66 -0.32 3.7e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7539409 0.651 rs910182 chr1:84297117 A/G cg10977910 chr1:84465055 TTLL7 0.67 10.29 0.38 4.55e-23 Alzheimer's disease; BRCA trans rs35110281 0.774 rs2838321 chr21:44995488 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.15 0.31 1.92e-15 Mean corpuscular volume; BRCA cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.07 -0.37 3.1e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.71 0.39 1.02e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9463078 0.774 rs4446571 chr6:45257662 T/C cg25276700 chr6:44698697 NA -0.35 -7.9 -0.3 1.25e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs877529 0.967 rs139400 chr22:39545396 C/T cg12193277 chr22:39547181 CBX7 0.48 13.26 0.46 1.29e-35 Multiple myeloma; BRCA cis rs9790314 1.000 rs336570 chr3:161072054 A/G cg03342759 chr3:160939853 NMD3 0.63 13.78 0.48 5.16e-38 Morning vs. evening chronotype; BRCA cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.32e-16 Monocyte percentage of white cells; BRCA trans rs1829883 0.685 rs7448995 chr5:98709481 C/T cg08333243 chr5:99726346 NA 0.34 8.24 0.31 9.73e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6710529 1 rs6710529 chr2:219645553 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -10.86 -0.39 2.58e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg04944784 chr2:26401820 FAM59B -0.62 -10.76 -0.39 6.13e-25 Gut microbiome composition (summer); BRCA cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg20848291 chr7:100343083 ZAN -0.61 -11.72 -0.42 7.38e-29 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs919433 0.679 rs10166328 chr2:198511917 A/G cg00792783 chr2:198669748 PLCL1 0.41 9.06 0.34 1.52e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7149337 0.717 rs4309324 chr14:51606336 A/T cg23942311 chr14:51606299 NA -0.54 -16.15 -0.54 1.91e-49 Cancer; BRCA cis rs7246657 0.943 rs3803895 chr19:37898669 A/G cg23950597 chr19:37808831 NA -0.62 -11.39 -0.41 1.64e-27 Coronary artery calcification; BRCA cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg24562669 chr7:97807699 LMTK2 0.43 11.34 0.41 2.65e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06544989 chr22:39130855 UNC84B 0.4 8.81 0.33 1.21e-17 Menopause (age at onset); BRCA cis rs6840360 0.571 rs11736116 chr4:152531816 A/G cg22705602 chr4:152727874 NA -0.32 -8.28 -0.31 7.42e-16 Intelligence (multi-trait analysis); BRCA cis rs7903847 0.642 rs3814553 chr10:99155984 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.53 -0.32 1.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.35 -0.38 2.57e-23 Schizophrenia; BRCA cis rs9814567 1.000 rs3932818 chr3:134206069 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.36 -0.61 4.51e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs7824557 0.675 rs2736265 chr8:11186674 A/G cg06636001 chr8:8085503 FLJ10661 0.48 10.15 0.37 1.49e-22 Retinal vascular caliber; BRCA cis rs7582720 1.000 rs72934714 chr2:203711581 T/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 12.51 0.44 2.8e-32 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs2882667 0.931 rs10075039 chr5:138337854 A/G cg04439458 chr5:138467593 SIL1 -0.33 -9.1 -0.34 1.16e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1215050 0.791 rs1530904 chr4:98805436 A/G cg05340658 chr4:99064831 C4orf37 0.44 10.13 0.37 1.74e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11105298 0.891 rs10777163 chr12:89830720 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.49 -8.66 -0.32 3.93e-17 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg24562669 chr7:97807699 LMTK2 0.7 21.93 0.66 6.42e-80 Breast cancer; BRCA cis rs13256369 0.755 rs12680167 chr8:8562467 A/G cg06671706 chr8:8559999 CLDN23 0.44 8.62 0.32 5.07e-17 Obesity-related traits; BRCA cis rs2997447 0.655 rs2275949 chr1:26385150 C/G cg19633962 chr1:26362018 EXTL1 -0.58 -10.26 -0.38 5.73e-23 QRS complex (12-leadsum); BRCA cis rs9818758 0.607 rs9990153 chr3:49291883 C/T cg00383909 chr3:49044727 WDR6 0.73 12.97 0.46 2.53e-34 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7091068 0.550 rs7901909 chr10:95492508 C/T cg20715218 chr10:95462985 C10orf4 0.53 10.6 0.39 2.76e-24 Urinary tract infection frequency; BRCA cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg08508325 chr11:3079039 CARS 0.28 8.52 0.32 1.17e-16 Calcium levels; BRCA cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg17724175 chr1:150552817 MCL1 0.25 8.34 0.31 4.62e-16 Tonsillectomy; BRCA cis rs6835098 0.828 rs28612521 chr4:174085294 G/A cg08422745 chr4:174089978 GALNT7 -0.81 -18.47 -0.59 2.37e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg24250549 chr1:154909240 PMVK 0.66 17.58 0.57 1.04e-56 Prostate cancer; BRCA cis rs6459804 1.000 rs6459806 chr7:157510483 C/G cg05731713 chr7:157510257 PTPRN2 0.4 10.38 0.38 2.06e-23 Bipolar disorder and schizophrenia; BRCA cis rs7555523 0.887 rs10800155 chr1:165723770 A/G cg24409356 chr1:165738333 TMCO1 0.46 8.32 0.31 5.31e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.52 10.93 0.4 1.35e-25 Lymphocyte counts; BRCA trans rs208520 0.526 rs7776413 chr6:66783241 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.15 -39.06 -0.84 1.79e-171 Exhaled nitric oxide output; BRCA cis rs6424115 0.729 rs586173 chr1:24055718 A/G cg10978503 chr1:24200527 CNR2 -0.42 -10.51 -0.38 5.86e-24 Immature fraction of reticulocytes; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.21 -0.31 1.25e-15 Schizophrenia; BRCA cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg18876405 chr7:65276391 NA 0.61 15.04 0.51 5.24e-44 Aortic root size; BRCA cis rs11024102 0.830 rs11024110 chr11:17028390 T/A cg15378786 chr11:17036137 PLEKHA7 0.47 8.62 0.32 5.16e-17 Glaucoma (primary angle closure); BRCA cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg11843238 chr5:131593191 PDLIM4 0.35 7.93 0.3 1.01e-14 Breast cancer; BRCA cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11644478 chr21:40555479 PSMG1 -0.52 -10.93 -0.4 1.36e-25 Menarche (age at onset); BRCA cis rs11098499 0.954 rs11098526 chr4:120390359 C/T cg09307838 chr4:120376055 NA 0.73 15.4 0.52 9.48e-46 Corneal astigmatism; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg08742575 chr21:47604166 C21orf56 -0.41 -7.97 -0.3 7.33e-15 Testicular germ cell tumor; BRCA cis rs4319547 0.695 rs10846746 chr12:122868696 C/T cg23029597 chr12:123009494 RSRC2 0.63 12.29 0.44 2.49e-31 Body mass index; BRCA cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg21427119 chr20:30132790 HM13 0.41 8.81 0.33 1.14e-17 Mean corpuscular hemoglobin; BRCA cis rs10267417 0.544 rs2072185 chr7:19748700 G/A cg05791153 chr7:19748676 TWISTNB 1.07 28.14 0.74 5.82e-114 Night sleep phenotypes; BRCA cis rs12310956 0.532 rs10844707 chr12:33936089 T/C cg06521331 chr12:34319734 NA -0.61 -11.17 -0.4 1.36e-26 Morning vs. evening chronotype; BRCA trans rs2204008 0.805 rs12146846 chr12:37985847 C/T cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.31e-21 Bladder cancer; BRCA cis rs10504073 0.647 rs12156111 chr8:50017328 G/C cg00325661 chr8:49890786 NA 0.38 11.19 0.4 1.12e-26 Blood metabolite ratios; BRCA cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.13 0.31 2.19e-15 Breast cancer; BRCA cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs41005 1.000 rs35398717 chr2:8115041 A/T cg03155496 chr2:8117019 LOC339788 -0.58 -15.78 -0.53 1.35e-47 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg06636001 chr8:8085503 FLJ10661 -0.45 -9.4 -0.35 9.49e-20 Myopia;Myopia (pathological); BRCA cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg18252515 chr7:66147081 NA -0.56 -11.34 -0.41 2.84e-27 Corneal structure; BRCA trans rs35110281 0.748 rs1584918 chr21:45042419 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.37 0.38 2.16e-23 Mean corpuscular volume; BRCA cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -16.32 -0.54 2.48e-50 Chronic sinus infection; BRCA cis rs7586879 0.789 rs11688754 chr2:25133885 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.56 0.35 2.55e-20 Body mass index; BRCA cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4478858 0.684 rs10798837 chr1:31719340 C/T cg00250761 chr1:31883323 NA -0.31 -8.0 -0.3 6.03e-15 Alcohol dependence; BRCA cis rs11098499 0.865 rs9996417 chr4:120295862 T/C cg09307838 chr4:120376055 NA 0.73 15.95 0.53 1.9e-48 Corneal astigmatism; BRCA cis rs3008870 0.755 rs2815381 chr1:67514591 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.59 12.41 0.44 7.44e-32 Lymphocyte percentage of white cells; BRCA cis rs1904096 0.506 rs2865350 chr4:95212813 A/T cg11021082 chr4:95130006 SMARCAD1 0.4 8.42 0.32 2.41e-16 Type 2 diabetes; BRCA cis rs7918232 0.574 rs10458708 chr10:27455605 C/T cg14442939 chr10:27389572 ANKRD26 0.79 19.8 0.62 2.09e-68 Breast cancer; BRCA cis rs7178424 1.000 rs12439356 chr15:62380595 A/G cg00456672 chr15:62358751 C2CD4A -0.35 -8.3 -0.31 6.17e-16 Height; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg10729496 chr3:10149963 C3orf24 0.48 9.03 0.34 1.93e-18 Alzheimer's disease; BRCA trans rs4332037 0.624 rs73046339 chr7:1889300 G/A cg25206134 chr2:45395956 NA 0.53 8.98 0.33 3.03e-18 Bipolar disorder; BRCA cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg02659138 chr7:134003124 SLC35B4 -0.34 -10.63 -0.39 2e-24 Mean platelet volume; BRCA cis rs3849570 0.696 rs13092157 chr3:81875332 T/A cg07356753 chr3:81810745 GBE1 -0.43 -9.95 -0.37 8.89e-22 Waist circumference;Body mass index; BRCA cis rs8114671 0.562 rs3818273 chr20:33509275 G/A cg07148914 chr20:33460835 GGT7 0.38 8.62 0.32 5.21e-17 Height; BRCA cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg00074818 chr8:8560427 CLDN23 0.4 8.63 0.32 4.93e-17 Obesity-related traits; BRCA cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg10253484 chr15:75165896 SCAMP2 0.57 11.87 0.42 1.7e-29 Breast cancer; BRCA cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg03934865 chr2:198174659 NA -0.4 -9.05 -0.34 1.71e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs2736345 0.788 rs998683 chr8:11353000 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -8.66 -0.32 3.86e-17 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs2882667 0.627 rs1549203 chr5:138468344 A/G cg04439458 chr5:138467593 SIL1 0.35 9.75 0.36 5.02e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 0.862 rs709609 chr7:65560561 A/G cg18876405 chr7:65276391 NA -0.52 -11.65 -0.42 1.39e-28 Aortic root size; BRCA cis rs2712184 0.729 rs4674115 chr2:217659628 C/G cg05032264 chr2:217675019 NA -0.35 -8.37 -0.31 3.58e-16 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg07520158 chr7:32535189 LSM5;AVL9 -0.47 -10.27 -0.38 5.43e-23 Cognitive ability; BRCA cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg24642439 chr20:33292090 TP53INP2 -0.4 -8.36 -0.31 3.96e-16 Height; BRCA cis rs1505368 0.781 rs10197836 chr2:213274278 T/C cg16329650 chr2:213403929 ERBB4 0.32 8.01 0.3 5.5e-15 Symmetrical dimethylarginine levels; BRCA cis rs208520 0.526 rs7776413 chr6:66783241 A/G cg07460842 chr6:66804631 NA -1.19 -38.95 -0.84 6.75e-171 Exhaled nitric oxide output; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg04166393 chr7:2884313 GNA12 0.47 9.42 0.35 7.99e-20 Height; BRCA cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24110177 chr3:50126178 RBM5 0.38 10.57 0.39 3.58e-24 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.595 rs12525810 chr6:26623511 T/A cg09904177 chr6:26538194 HMGN4 0.43 12.21 0.43 5.66e-31 Intelligence (multi-trait analysis); BRCA cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.42 0.52 7.63e-46 Colorectal cancer; BRCA cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.38 -0.31 3.25e-16 Aortic root size; BRCA cis rs10733682 0.659 rs3906146 chr9:129463613 C/T cg00232160 chr9:129468157 NA 0.36 8.41 0.32 2.67e-16 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg11062466 chr8:58055876 NA 0.5 8.8 0.33 1.28e-17 Developmental language disorder (linguistic errors); BRCA cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg08917208 chr2:24149416 ATAD2B 0.96 14.26 0.49 2.85e-40 Lymphocyte counts; BRCA cis rs708547 0.957 rs2458552 chr4:57773442 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.47 -8.17 -0.31 1.63e-15 Response to bleomycin (chromatid breaks); BRCA cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.43 0.44 6.36e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs832540 0.618 rs41106 chr5:56145057 G/T cg24531977 chr5:56204891 C5orf35 -0.54 -11.41 -0.41 1.38e-27 Coronary artery disease; BRCA cis rs9815354 0.680 rs17218936 chr3:42019392 C/T cg03022575 chr3:42003672 ULK4 0.77 9.77 0.36 4e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg16262614 chr3:133464971 TF 0.24 7.88 0.3 1.45e-14 Iron status biomarkers (transferrin levels); BRCA cis rs3106136 0.546 rs183993 chr4:95130025 G/A cg11021082 chr4:95130006 SMARCAD1 -0.43 -9.96 -0.37 8.4e-22 Capecitabine sensitivity; BRCA cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.88 -0.33 6.48e-18 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.782 rs4818856 chr21:45043495 A/G cg01579765 chr21:45077557 HSF2BP -0.43 -11.45 -0.41 1e-27 Mean corpuscular volume; BRCA cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg11266682 chr4:10021025 SLC2A9 0.5 13.24 0.46 1.63e-35 Bone mineral density; BRCA cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg05340658 chr4:99064831 C4orf37 -0.69 -17.44 -0.57 5.08e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.26 -0.31 8.65e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg05347473 chr6:146136440 FBXO30 -0.39 -7.87 -0.3 1.5e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg03146154 chr1:46216737 IPP 0.53 11.92 0.43 1e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7914558 0.899 rs7913682 chr10:104684392 T/A cg04362960 chr10:104952993 NT5C2 0.43 10.26 0.38 5.93e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs17384381 1.000 rs17388521 chr1:85897904 A/G cg16011679 chr1:85725395 C1orf52 -0.53 -8.26 -0.31 8.7e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11971779 0.680 rs7804388 chr7:139086413 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.0 -0.56 9.9e-54 Intelligence (multi-trait analysis); BRCA cis rs701145 0.824 rs355767 chr3:154045895 G/A cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs9815354 0.680 rs115754309 chr3:42017246 A/G cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs35110281 0.633 rs4819292 chr21:45125223 A/G cg21573476 chr21:45109991 RRP1B -0.39 -10.38 -0.38 1.94e-23 Mean corpuscular volume; BRCA cis rs6820391 0.816 rs7683461 chr4:54447863 C/T cg04173182 chr4:54446035 LNX1 0.53 11.9 0.43 1.27e-29 Cervical artery dissection; BRCA trans rs2736345 0.788 rs2618476 chr8:11352541 A/G cg06636001 chr8:8085503 FLJ10661 0.43 7.94 0.3 8.95e-15 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs72720396 0.789 rs10922910 chr1:91199862 G/T cg13456504 chr1:91191583 NA 0.54 9.95 0.37 9.1e-22 Morning vs. evening chronotype;Chronotype; BRCA cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg12310025 chr6:25882481 NA 0.72 17.89 0.58 2.43e-58 Blood metabolite levels; BRCA cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg11645453 chr3:52864694 ITIH4 0.48 11.63 0.42 1.73e-28 Schizophrenia; BRCA cis rs9300255 0.620 rs1727311 chr12:123660716 T/G cg00376283 chr12:123451042 ABCB9 0.51 9.74 0.36 5.37e-21 Neutrophil percentage of white cells; BRCA cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg19784903 chr17:45786737 TBKBP1 -0.42 -9.93 -0.37 1.09e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg06627628 chr2:24431161 ITSN2 -0.54 -8.91 -0.33 5.27e-18 Lymphocyte counts; BRCA cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg20701182 chr2:24300061 SF3B14 0.7 13.41 0.47 2.62e-36 Lymphocyte counts; BRCA cis rs9296092 0.538 rs9461881 chr6:33520041 C/T cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA trans rs877282 0.733 rs7092976 chr10:756358 G/A cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs782590 0.574 rs12991445 chr2:55675939 C/T cg18811423 chr2:55921094 PNPT1 0.46 12.06 0.43 2.6e-30 Metabolic syndrome; BRCA cis rs3768617 1.000 rs3820697 chr1:183100226 T/C ch.1.3577855R chr1:183094577 LAMC1 0.45 10.13 0.37 1.84e-22 Fuchs's corneal dystrophy; BRCA cis rs9309473 0.718 rs10175529 chr2:73606093 A/G cg20560298 chr2:73613845 ALMS1 -0.46 -12.64 -0.45 7.81e-33 Metabolite levels; BRCA cis rs10267417 0.603 rs10281428 chr7:19857374 G/A cg05791153 chr7:19748676 TWISTNB 0.51 9.71 0.36 6.75e-21 Night sleep phenotypes; BRCA cis rs4660306 1.000 rs6429567 chr1:45956700 C/A cg24296786 chr1:45957014 TESK2 0.42 8.38 0.31 3.31e-16 Homocysteine levels; BRCA cis rs11625487 0.957 rs28820314 chr14:77963272 A/C cg20045696 chr14:77926864 AHSA1 -0.43 -8.01 -0.3 5.47e-15 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; BRCA cis rs72772090 0.539 rs111886458 chr5:96125047 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7729447 0.776 rs7738037 chr5:32696549 C/T cg16267343 chr5:32710456 NPR3 0.47 9.82 0.36 2.65e-21 Blood pressure; BRCA cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg14926445 chr8:58193284 C8orf71 -0.38 -7.82 -0.3 2.2e-14 Developmental language disorder (linguistic errors); BRCA trans rs12517041 1.000 rs34157151 chr5:23289755 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs6772849 0.930 rs68090762 chr3:128343907 C/T cg16766828 chr3:128327626 NA -0.41 -8.94 -0.33 4.03e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Smoking initiation; BRCA cis rs9649465 0.967 rs12537072 chr7:123377213 A/G cg04330084 chr7:123175371 IQUB -0.33 -8.98 -0.33 2.94e-18 Migraine; BRCA cis rs2012796 0.665 rs72703728 chr14:81834523 G/A cg02996355 chr14:81879375 NA 0.57 11.59 0.42 2.53e-28 Night sleep phenotypes; BRCA cis rs13053817 1.000 rs13053817 chr22:29847722 A/C cg20285224 chr22:29838184 RFPL1S;RFPL1 0.47 9.29 0.34 2.43e-19 Carotid atherosclerosis in HIV infection; BRCA trans rs35110281 0.840 rs7276633 chr21:45078800 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.23 0.31 1.08e-15 Mean corpuscular volume; BRCA trans rs2204008 0.576 rs11519979 chr12:37999413 C/T cg06521331 chr12:34319734 NA -0.54 -9.65 -0.36 1.18e-20 Bladder cancer; BRCA cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14442939 chr10:27389572 ANKRD26 0.65 10.87 0.39 2.37e-25 Breast cancer; BRCA trans rs3749237 0.964 rs1799845 chr3:49847623 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.33 8.32 0.31 5.32e-16 Resting heart rate; BRCA cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg00071950 chr4:10020882 SLC2A9 0.55 13.19 0.46 2.62e-35 Bone mineral density; BRCA cis rs10504073 0.584 rs10504070 chr8:49978554 A/G cg00325661 chr8:49890786 NA -0.44 -12.83 -0.45 1.07e-33 Blood metabolite ratios; BRCA cis rs965469 1.000 rs2092990 chr20:3346338 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -10.54 -0.38 4.61e-24 IFN-related cytopenia; BRCA cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -11.85 -0.42 2.06e-29 Tonsillectomy; BRCA cis rs868036 0.609 rs13329413 chr15:68097126 C/T cg24579218 chr15:68104479 NA -0.36 -7.88 -0.3 1.38e-14 Restless legs syndrome; BRCA trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21659725 chr3:3221576 CRBN 0.71 21.89 0.65 1.09e-79 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg16145915 chr7:1198662 ZFAND2A -0.66 -17.91 -0.58 1.86e-58 Longevity;Endometriosis; BRCA cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.86 0.33 7.82e-18 Motion sickness; BRCA cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.78 -0.36 3.91e-21 Developmental language disorder (linguistic errors); BRCA cis rs6546537 0.562 rs7565783 chr2:69750113 C/T cg10773587 chr2:69614142 GFPT1 -0.38 -8.58 -0.32 7.45e-17 Serum thyroid-stimulating hormone levels; BRCA cis rs6723226 0.750 rs10182170 chr2:32704186 G/A cg02381751 chr2:32503542 YIPF4 0.67 14.7 0.5 2.31e-42 Intelligence (multi-trait analysis); BRCA cis rs9325144 0.647 rs12229104 chr12:39110811 T/A cg26384229 chr12:38710491 ALG10B -0.49 -11.33 -0.41 2.91e-27 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs188102 chr2:200903189 T/A cg23649088 chr2:200775458 C2orf69 -0.55 -7.86 -0.3 1.68e-14 Schizophrenia; BRCA cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.83e-54 Bladder cancer; BRCA cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg06115741 chr20:33292138 TP53INP2 0.47 10.71 0.39 1.02e-24 Coronary artery disease; BRCA cis rs4853036 0.586 rs6546546 chr2:70009035 A/C cg02498382 chr2:70120550 SNRNP27 0.44 8.33 0.31 4.95e-16 Colorectal or endometrial cancer; BRCA cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg26384229 chr12:38710491 ALG10B 0.74 17.29 0.56 3.29e-55 Bladder cancer; BRCA trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg06636001 chr8:8085503 FLJ10661 0.54 10.69 0.39 1.16e-24 Retinal vascular caliber; BRCA cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg11645453 chr3:52864694 ITIH4 0.47 11.31 0.41 3.56e-27 Schizophrenia; BRCA cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg19077165 chr18:44547161 KATNAL2 0.65 14.94 0.51 1.71e-43 Personality dimensions; BRCA cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg13114125 chr14:105738426 BRF1 -0.5 -10.41 -0.38 1.44e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs17401966 0.867 rs12403443 chr1:10423988 A/G cg03954927 chr1:10346856 KIF1B 0.45 12.39 0.44 9.86e-32 Hepatocellular carcinoma; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs10504229 1.000 rs17217047 chr8:58180296 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs2455799 0.574 rs2455801 chr3:15701857 C/T cg16303742 chr3:15540471 COLQ -0.37 -9.01 -0.34 2.31e-18 Mean platelet volume; BRCA cis rs2832077 0.943 rs2272701 chr21:30190907 C/T cg24692254 chr21:30365293 RNF160 -0.46 -8.03 -0.3 4.54e-15 Cognitive test performance; BRCA cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg15352829 chr14:105391018 PLD4 -0.38 -12.3 -0.44 2.41e-31 Rheumatoid arthritis; BRCA cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg23625390 chr15:77176239 SCAPER 0.4 9.37 0.35 1.23e-19 Blood metabolite levels; BRCA cis rs765787 0.530 rs1706830 chr15:45516229 G/A cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg17143192 chr8:8559678 CLDN23 0.55 10.38 0.38 2.04e-23 Obesity-related traits; BRCA cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.36 8.18 0.31 1.53e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs11250098 0.547 rs2409764 chr8:11281273 C/T cg06636001 chr8:8085503 FLJ10661 0.48 9.76 0.36 4.54e-21 Morning vs. evening chronotype; BRCA cis rs896854 0.738 rs2515226 chr8:95965743 G/A cg13393036 chr8:95962371 TP53INP1 0.34 8.35 0.31 4.26e-16 Type 2 diabetes; BRCA cis rs7631605 0.905 rs3774338 chr3:37062959 G/T cg15934958 chr3:37212084 LRRFIP2 0.44 10.18 0.37 1.2e-22 Cerebrospinal P-tau181p levels; BRCA cis rs4730250 0.707 rs6946931 chr7:106788621 G/T cg02696742 chr7:106810147 HBP1 -0.57 -9.14 -0.34 8.52e-19 Osteoarthritis; BRCA cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg13047869 chr3:10149882 C3orf24 0.59 12.21 0.44 5.53e-31 Alzheimer's disease; BRCA cis rs4363385 0.747 rs946101 chr1:152972032 C/T cg21543102 chr1:152974771 SPRR3 0.28 8.32 0.31 5.45e-16 Inflammatory skin disease; BRCA cis rs4363385 0.818 rs4284210 chr1:152985711 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.02 -0.34 2.09e-18 Inflammatory skin disease; BRCA cis rs11971779 0.878 rs4732378 chr7:139120395 C/T cg07862535 chr7:139043722 LUC7L2 0.51 12.17 0.43 8.39e-31 Diisocyanate-induced asthma; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg11814155 chr7:99998594 ZCWPW1 0.54 9.32 0.35 1.81e-19 Platelet count; BRCA cis rs9443645 0.527 rs9343870 chr6:79789473 T/G cg09184832 chr6:79620586 NA -0.42 -8.14 -0.31 2.06e-15 Intelligence (multi-trait analysis); BRCA cis rs7312933 0.703 rs10459290 chr12:42613290 T/G cg01256987 chr12:42539512 GXYLT1 -0.48 -9.27 -0.34 2.77e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs3818285 0.556 rs944966 chr10:111658334 C/G cg00817464 chr10:111662876 XPNPEP1 -0.37 -9.93 -0.37 1.05e-21 Superior crus of antihelix expression; BRCA trans rs11098499 0.739 rs4833612 chr4:120147596 A/C cg25214090 chr10:38739885 LOC399744 -0.46 -9.84 -0.36 2.35e-21 Corneal astigmatism; BRCA cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg24450063 chr1:156163899 SLC25A44 -1.04 -32.92 -0.79 9.46e-140 Testicular germ cell tumor; BRCA cis rs858239 0.600 rs10256361 chr7:23123885 C/T cg23682824 chr7:23144976 KLHL7 0.45 12.09 0.43 1.9e-30 Cerebrospinal fluid biomarker levels; BRCA trans rs60843830 1.000 rs56167434 chr2:282137 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.79 0.5 8.48e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg17366294 chr4:99064904 C4orf37 0.43 10.23 0.38 7.52e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg11845111 chr2:191398756 TMEM194B -0.37 -8.49 -0.32 1.43e-16 Pulse pressure; BRCA cis rs11098499 0.954 rs17046116 chr4:120387259 G/A cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.32 0.31 5.39e-16 Aortic root size; BRCA cis rs6580649 0.941 rs7310579 chr12:48427523 G/A cg24011408 chr12:48396354 COL2A1 -0.47 -7.83 -0.3 2.06e-14 Lung cancer; BRCA cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg15556689 chr8:8085844 FLJ10661 0.58 16.24 0.54 6.9e-50 Neuroticism; BRCA cis rs12681288 0.550 rs73176529 chr8:962283 G/C cg04851639 chr8:1020857 NA -0.32 -8.82 -0.33 1.05e-17 Schizophrenia; BRCA cis rs10927875 0.615 rs10927886 chr1:16339313 C/G cg06159980 chr1:16340746 HSPB7 0.36 8.36 0.31 3.78e-16 Dilated cardiomyopathy; BRCA cis rs733592 0.507 rs7299704 chr12:48444488 A/G cg24011408 chr12:48396354 COL2A1 0.42 9.36 0.35 1.38e-19 Plateletcrit; BRCA cis rs757081 0.667 rs12420958 chr11:17100432 G/T cg15432903 chr11:17409602 KCNJ11 -0.46 -8.59 -0.32 6.62e-17 Systolic blood pressure; BRCA cis rs17641971 0.899 rs341804 chr8:49991553 G/C cg00325661 chr8:49890786 NA -0.31 -8.16 -0.31 1.76e-15 Blood metabolite levels; BRCA cis rs2625529 0.730 rs982752 chr15:72145937 C/T cg16672083 chr15:72433130 SENP8 -0.69 -16.38 -0.54 1.37e-50 Red blood cell count; BRCA cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.75e-16 Menopause (age at onset); BRCA trans rs9858542 0.953 rs7633271 chr3:49555963 T/C cg21659725 chr3:3221576 CRBN -0.46 -10.09 -0.37 2.62e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs910316 0.967 rs175451 chr14:75589729 C/T cg23033748 chr14:75592666 NEK9 -0.42 -10.39 -0.38 1.86e-23 Height; BRCA cis rs6882046 0.513 rs446219 chr5:88005827 T/C cg22951263 chr5:87985283 NA -0.39 -10.8 -0.39 4.41e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs853679 0.517 rs4711165 chr6:28115184 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Depression; BRCA cis rs2806561 0.894 rs598438 chr1:23531563 C/T cg19743168 chr1:23544995 NA 0.46 11.18 0.4 1.21e-26 Height; BRCA cis rs9747201 1.000 rs9747201 chr17:80177852 A/C cg18209359 chr17:80159595 CCDC57 -0.4 -7.9 -0.3 1.22e-14 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs853679 0.517 rs11552219 chr6:28126834 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg24531977 chr5:56204891 C5orf35 -0.86 -17.89 -0.58 2.57e-58 Initial pursuit acceleration; BRCA cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg12311346 chr5:56204834 C5orf35 0.8 15.66 0.53 5.31e-47 Initial pursuit acceleration; BRCA cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.84 0.36 2.34e-21 Bipolar disorder; BRCA cis rs2243480 1.000 rs35542501 chr7:65431215 T/C cg18252515 chr7:66147081 NA -0.82 -11.95 -0.43 7.52e-30 Diabetic kidney disease; BRCA cis rs483180 0.512 rs597308 chr1:120214953 G/A cg19096424 chr1:120255104 PHGDH 0.44 9.59 0.35 1.93e-20 Macular telangiectasia type 2; BRCA cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg11663144 chr21:46675770 NA -0.61 -14.1 -0.49 1.67e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg06238570 chr21:40685208 BRWD1 -0.43 -8.51 -0.32 1.25e-16 Cognitive function; BRCA cis rs6882046 0.513 rs185291 chr5:88006764 T/C cg22951263 chr5:87985283 NA -0.39 -10.75 -0.39 6.62e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs7737355 0.947 rs10463887 chr5:130776854 C/G cg06307176 chr5:131281290 NA -0.54 -10.76 -0.39 6.02e-25 Life satisfaction; BRCA cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg19784903 chr17:45786737 TBKBP1 0.34 8.03 0.3 4.66e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.51 -0.38 5.96e-24 Intelligence (multi-trait analysis); BRCA cis rs1451375 0.652 rs7803440 chr7:50625632 C/T cg18232548 chr7:50535776 DDC 0.38 8.03 0.3 4.84e-15 Malaria; BRCA cis rs57590327 0.555 rs6767749 chr3:81725513 G/A cg07356753 chr3:81810745 GBE1 -0.46 -10.98 -0.4 7.87e-26 Extraversion; BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg25036284 chr2:26402008 FAM59B 0.73 12.02 0.43 3.63e-30 Gut microbiome composition (summer); BRCA cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg04267008 chr7:1944627 MAD1L1 -0.66 -13.92 -0.48 1.17e-38 Bipolar disorder and schizophrenia; BRCA cis rs9653442 0.675 rs12995420 chr2:100652578 T/C cg22139774 chr2:100720529 AFF3 -0.29 -8.18 -0.31 1.5e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg15934090 chr1:100435551 SLC35A3 0.35 8.05 0.3 3.94e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs4595586 0.505 rs12827136 chr12:39412790 C/T cg26384229 chr12:38710491 ALG10B 0.41 8.97 0.33 3.36e-18 Morning vs. evening chronotype; BRCA cis rs17270561 0.666 rs9356987 chr6:25739187 C/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.86 0.33 8.17e-18 Iron status biomarkers; BRCA cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg26677194 chr12:130822605 PIWIL1 0.6 14.39 0.49 7.41e-41 Menopause (age at onset); BRCA cis rs459571 1.000 rs456207 chr9:136911140 G/A cg13789015 chr9:136890014 NCRNA00094 0.57 11.94 0.43 8.55e-30 Platelet distribution width; BRCA cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg17971929 chr21:40555470 PSMG1 0.76 16.65 0.55 5.41e-52 Cognitive function; BRCA cis rs490234 0.966 rs631287 chr9:128412676 G/A cg14078157 chr9:128172775 NA 0.33 8.13 0.31 2.31e-15 Mean arterial pressure; BRCA cis rs9486719 0.749 rs1009596 chr6:96843688 A/G cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs10751667 0.666 rs7124480 chr11:971601 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.7 0.53 3.1e-47 Alzheimer's disease (late onset); BRCA cis rs12497850 0.931 rs6446253 chr3:48911443 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.67 0.36 9.4499999999999992e-21 Parkinson's disease; BRCA cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg11663144 chr21:46675770 NA -0.47 -11.21 -0.41 9.07e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs12517041 1.000 rs1428623 chr5:23286659 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.35 -0.31 4.37e-16 Calcium levels; BRCA cis rs12478296 0.792 rs6738361 chr2:243014257 C/T cg06360820 chr2:242988706 NA -0.83 -14.87 -0.51 3.68e-43 Obesity-related traits; BRCA cis rs6815814 0.898 rs5743592 chr4:38803063 A/G cg02016764 chr4:38805732 TLR1 -0.59 -9.67 -0.36 9.75e-21 Breast cancer; BRCA cis rs919433 0.619 rs699318 chr2:198281743 T/C cg00792783 chr2:198669748 PLCL1 0.39 8.74 0.33 2e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs11764590 0.715 rs11760737 chr7:2104055 T/C cg02743256 chr7:2109353 MAD1L1 -0.46 -8.17 -0.31 1.59e-15 Neuroticism; BRCA cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs6973256 0.897 rs10231828 chr7:133348337 T/G cg07491979 chr7:133331646 EXOC4 -0.39 -9.04 -0.34 1.92e-18 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg13902645 chr11:5959945 NA -0.53 -10.98 -0.4 8.22e-26 DNA methylation (variation); BRCA trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg03929089 chr4:120376271 NA 0.65 12.85 0.45 8.83e-34 Coronary artery disease; BRCA cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg26898376 chr11:64110657 CCDC88B 0.37 7.86 0.3 1.69e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs858239 0.539 rs6976957 chr7:23187333 T/A cg23682824 chr7:23144976 KLHL7 0.41 10.65 0.39 1.74e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg21226059 chr5:178986404 RUFY1 0.4 10.44 0.38 1.13e-23 Lung cancer; BRCA cis rs77633900 0.614 rs280001 chr15:77003566 C/A cg21673338 chr15:77095150 SCAPER -0.54 -9.56 -0.35 2.39e-20 Non-glioblastoma glioma;Glioma; BRCA cis rs587080 0.559 rs12364730 chr11:65228278 C/T cg01292856 chr11:65242576 NA 0.66 14.6 0.5 7.11e-42 Plateletcrit; BRCA trans rs11098499 0.542 rs10440343 chr4:120309787 G/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs9296092 0.517 rs11752179 chr6:33534713 G/T cg13560919 chr6:33536144 NA -0.91 -19.42 -0.61 2.12e-66 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg18225595 chr11:63971243 STIP1 0.53 9.59 0.35 1.8899999999999998e-20 Mean platelet volume; BRCA cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg02475777 chr4:1388615 CRIPAK -0.67 -12.53 -0.44 2.24e-32 Longevity; BRCA cis rs503734 0.502 rs1994201 chr3:100970062 C/T cg27318481 chr3:100970896 IMPG2 0.39 9.56 0.35 2.51e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1003719 0.788 rs2835588 chr21:38462716 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2070488 1.000 rs2268753 chr3:38500189 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.59 0.63 1.23e-72 Electrocardiographic conduction measures; BRCA cis rs250677 0.522 rs3763022 chr5:148381078 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -8.86 -0.33 8.15e-18 Breast cancer; BRCA cis rs1997103 1.000 rs10263552 chr7:55404747 C/T cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.92e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs8005677 1.000 rs8014936 chr14:23375145 A/G cg01529538 chr14:23388837 RBM23 0.42 11.56 0.42 3.3e-28 Cognitive ability (multi-trait analysis); BRCA cis rs858239 0.665 rs6964665 chr7:23211352 G/A cg23682824 chr7:23144976 KLHL7 0.36 9.29 0.35 2.34e-19 Cerebrospinal fluid biomarker levels; BRCA cis rs7267979 0.868 rs6138553 chr20:25239233 G/A cg08601574 chr20:25228251 PYGB 0.41 9.69 0.36 7.97e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg19628046 chr18:33552617 C18orf21 0.56 11.5 0.41 6.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs12541635 0.677 rs1603357 chr8:107000565 G/C cg10147462 chr8:107024639 NA 0.39 10.51 0.38 5.98e-24 Age of smoking initiation; BRCA cis rs1580019 0.961 rs1610143 chr7:32498331 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.51 0.32 1.26e-16 Cognitive ability; BRCA cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg22535103 chr8:58192502 C8orf71 -0.46 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg00166722 chr3:10149974 C3orf24 0.61 11.95 0.43 7.46e-30 Alzheimer's disease; BRCA cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg21395723 chr22:39101663 GTPBP1 0.38 8.32 0.31 5.17e-16 Menopause (age at onset); BRCA cis rs853679 0.517 rs9368558 chr6:28133306 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs9287719 0.967 rs2884233 chr2:10745303 G/A cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs10911232 0.507 rs4651137 chr1:182994300 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs3820928 0.874 rs10194663 chr2:227875369 T/A cg11843606 chr2:227700838 RHBDD1 -0.37 -8.16 -0.31 1.77e-15 Pulmonary function; BRCA cis rs7520050 0.902 rs4638056 chr1:46458153 T/G cg24296786 chr1:45957014 TESK2 0.44 9.81 0.36 2.95e-21 Red blood cell count;Reticulocyte count; BRCA cis rs698833 0.926 rs1067339 chr2:44624448 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.8 0.39 4.44e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs853679 0.517 rs4713150 chr6:28136212 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -8.17 -0.31 1.64e-15 Longevity;Endometriosis; BRCA cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -17.03 -0.56 6.87e-54 Chronic sinus infection; BRCA cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.44 0.38 1.15e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2073300 0.609 rs6137930 chr20:23376732 G/A cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.43e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.27 0.31 7.79e-16 Aortic root size; BRCA cis rs17376456 1.000 rs59472588 chr5:93511981 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.17 0.31 1.63e-15 Diabetic retinopathy; BRCA cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg26031613 chr14:104095156 KLC1 -0.53 -9.46 -0.35 5.92e-20 Reticulocyte count; BRCA cis rs7973719 0.833 rs3825405 chr12:7360143 G/T cg07052231 chr12:7363540 PEX5 0.34 7.88 0.3 1.44e-14 IgG glycosylation; BRCA trans rs35110281 0.776 rs1073522 chr21:45009219 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.15 0.37 1.51e-22 Mean corpuscular volume; BRCA cis rs13053817 0.950 rs12484045 chr22:29828751 A/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.45 -8.95 -0.33 3.76e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg05084668 chr3:125655381 ALG1L -0.47 -7.98 -0.3 6.69e-15 Blood pressure (smoking interaction); BRCA cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg06212747 chr3:49208901 KLHDC8B 0.53 11.06 0.4 3.79e-26 Parkinson's disease; BRCA cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg17724175 chr1:150552817 MCL1 0.25 8.22 0.31 1.17e-15 Tonsillectomy; BRCA cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg04727924 chr7:799746 HEATR2 -0.5 -8.93 -0.33 4.51e-18 Cerebrospinal P-tau181p levels; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.45 0.66 9.38e-83 Platelet count; BRCA cis rs34779708 0.931 rs4934724 chr10:35393669 C/T cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.98e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs1997103 0.906 rs6593232 chr7:55402916 C/T cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs698813 0.674 rs6759891 chr2:44496005 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.88 0.33 6.56e-18 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg25237894 chr2:233734115 C2orf82 -0.43 -13.56 -0.47 5.32e-37 Coronary artery disease; BRCA cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg18479299 chr3:125709523 NA -0.57 -9.13 -0.34 9.11e-19 Blood pressure (smoking interaction); BRCA cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -11.8 -0.42 3.22e-29 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.819 rs1473579 chr11:48901553 A/G cg00717180 chr2:96193071 NA -0.31 -8.66 -0.32 3.9e-17 HDL cholesterol; BRCA cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg03709012 chr19:19516395 GATAD2A 0.78 17.26 0.56 4.62e-55 Tonsillectomy; BRCA cis rs7592578 0.713 rs60915953 chr2:191331304 G/C cg11845111 chr2:191398756 TMEM194B -0.81 -14.34 -0.49 1.21e-40 Diastolic blood pressure; BRCA cis rs9381107 0.932 rs16892279 chr6:9483186 A/G cg14735645 chr6:9486422 NA -0.46 -8.13 -0.31 2.29e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg23719950 chr11:63933701 MACROD1 -0.58 -9.68 -0.36 9.11e-21 Mean platelet volume; BRCA cis rs514406 0.679 rs499239 chr1:53310594 A/G cg24675658 chr1:53192096 ZYG11B -0.68 -15.38 -0.52 1.18e-45 Monocyte count; BRCA cis rs6545977 0.531 rs2539981 chr2:63104904 T/C cg17519650 chr2:63277830 OTX1 0.45 10.22 0.37 7.9e-23 Prostate cancer; BRCA cis rs11792861 0.926 rs77567374 chr9:111835034 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.19 0.31 1.46e-15 Menarche (age at onset); BRCA cis rs7493 1.000 rs7493 chr7:95034775 C/G cg01874867 chr7:94954059 PON1 0.39 8.15 0.31 1.89e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6545883 0.558 rs7587389 chr2:61649791 A/G cg15711740 chr2:61764176 XPO1 0.32 7.88 0.3 1.44e-14 Tuberculosis; BRCA cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11890956 chr21:40555474 PSMG1 -0.65 -14.71 -0.5 2.2e-42 Menarche (age at onset); BRCA cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg03264133 chr6:25882463 NA -0.45 -9.6 -0.36 1.71e-20 Intelligence (multi-trait analysis); BRCA cis rs41005 0.967 rs13430914 chr2:8114648 A/G cg03155496 chr2:8117019 LOC339788 0.58 15.69 0.53 3.57e-47 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.93 -0.37 1.07e-21 Tonsillectomy; BRCA trans rs3858145 0.588 rs55888445 chr10:70036456 C/T cg04882175 chr6:131122610 NA -0.35 -8.35 -0.31 4.33e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs924607 1.000 rs12523022 chr5:598643 C/T cg24163568 chr5:669837 TPPP -0.35 -9.38 -0.35 1.17e-19 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs12618769 0.652 rs1062847 chr2:99226173 T/A cg10123293 chr2:99228465 UNC50 0.42 8.42 0.32 2.56e-16 Bipolar disorder; BRCA cis rs9790314 1.000 rs4273380 chr3:160950314 A/G cg03342759 chr3:160939853 NMD3 -0.63 -13.38 -0.47 3.57e-36 Morning vs. evening chronotype; BRCA cis rs7523050 0.730 rs77425121 chr1:109417677 C/A cg08274380 chr1:109419600 GPSM2 1.18 16.65 0.55 5.73e-52 Fat distribution (HIV); BRCA cis rs4481887 1.000 rs6683717 chr1:248476792 A/G cg00666640 chr1:248458726 OR2T12 0.34 9.07 0.34 1.39e-18 Common traits (Other); BRCA cis rs7809950 0.678 rs17154040 chr7:107005246 C/T cg23024343 chr7:107201750 COG5 0.46 9.5 0.35 3.98e-20 Coronary artery disease; BRCA cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg20848291 chr7:100343083 ZAN -0.63 -13.31 -0.47 7.55e-36 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs9633740 0.685 rs4934284 chr10:82277297 C/G cg01528321 chr10:82214614 TSPAN14 -0.94 -12.03 -0.43 3.43e-30 Post bronchodilator FEV1; BRCA cis rs9393777 0.513 rs34388707 chr6:27050396 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -8.29 -0.31 6.81e-16 Intelligence (multi-trait analysis); BRCA cis rs1595825 0.891 rs2293255 chr2:198621506 T/C cg19156104 chr2:198669113 PLCL1 -0.41 -7.87 -0.3 1.53e-14 Ulcerative colitis; BRCA cis rs877529 0.967 rs6001455 chr22:39547962 C/T cg18708252 chr22:39545030 CBX7 -0.31 -8.17 -0.31 1.63e-15 Multiple myeloma; BRCA cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs965469 0.779 rs6051752 chr20:3310452 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.87 -0.33 7.39e-18 IFN-related cytopenia; BRCA cis rs6831352 1.000 rs6831352 chr4:100063525 T/C cg12011299 chr4:100065546 ADH4 0.52 12.53 0.44 2.37e-32 Alcohol dependence; BRCA cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg08999081 chr20:33150536 PIGU 0.37 9.4 0.35 9.65e-20 Coronary artery disease; BRCA cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg21573476 chr21:45109991 RRP1B -0.36 -9.15 -0.34 7.52e-19 Mean corpuscular volume; BRCA cis rs6594499 0.872 rs2112541 chr5:110449346 T/C cg04022379 chr5:110408740 TSLP 0.35 7.93 0.3 1.02e-14 Allergic disease (asthma, hay fever or eczema); BRCA cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.45 -8.53 -0.32 1.05e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1577917 0.958 rs2324817 chr6:86462654 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -8.08 -0.3 3.15e-15 Response to antipsychotic treatment; BRCA trans rs2204008 0.546 rs11519978 chr12:37998170 C/T cg06521331 chr12:34319734 NA -0.53 -9.61 -0.36 1.57e-20 Bladder cancer; BRCA cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg16099169 chr2:106886729 NA -0.69 -12.12 -0.43 1.44e-30 Facial morphology (factor 23); BRCA cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg15395560 chr15:45543142 SLC28A2 -0.29 -7.81 -0.3 2.33e-14 Uric acid levels; BRCA cis rs701145 0.556 rs355764 chr3:154013480 A/T cg12800244 chr3:153838788 SGEF 0.43 8.5 0.32 1.31e-16 Coronary artery disease; BRCA cis rs11031096 0.711 rs4910890 chr11:4153407 C/T cg18678763 chr11:4115507 RRM1 -0.38 -8.58 -0.32 7.01e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.34 -0.41 2.88e-27 Electroencephalogram traits; BRCA cis rs7100689 0.577 rs2282367 chr10:82040346 A/G cg01528321 chr10:82214614 TSPAN14 0.84 18.47 0.59 2.32e-61 Post bronchodilator FEV1; BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.59 -0.39 3.03e-24 Initial pursuit acceleration; BRCA trans rs9650657 0.771 rs6601513 chr8:10594843 A/G cg15556689 chr8:8085844 FLJ10661 -0.3 -7.91 -0.3 1.17e-14 Neuroticism; BRCA cis rs10911251 0.528 rs10911265 chr1:183115071 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 15.76 0.53 1.6e-47 Colorectal cancer; BRCA cis rs2637266 1.000 rs12262400 chr10:78386862 T/C cg18941641 chr10:78392320 NA 0.34 7.88 0.3 1.46e-14 Pulmonary function; BRCA cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg19077165 chr18:44547161 KATNAL2 -0.58 -13.0 -0.46 1.81e-34 Personality dimensions; BRCA cis rs2066819 1.000 rs11171803 chr12:56718422 T/C cg26714650 chr12:56694279 CS -1.19 -15.59 -0.52 1.14e-46 Psoriasis vulgaris; BRCA cis rs950776 0.714 rs514743 chr15:78884227 A/T cg06917634 chr15:78832804 PSMA4 -0.61 -13.08 -0.46 8.34e-35 Sudden cardiac arrest; BRCA cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg05535760 chr7:792225 HEATR2 0.7 12.65 0.45 6.83e-33 Cerebrospinal P-tau181p levels; BRCA cis rs7523273 0.925 rs10863593 chr1:208018074 C/T cg22525895 chr1:207977042 MIR29B2 0.47 11.54 0.42 4.23e-28 Schizophrenia; BRCA cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg25801113 chr15:45476975 SHF 0.31 8.06 0.3 3.9e-15 Uric acid levels; BRCA cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.09 -0.3 2.95e-15 Depression; BRCA cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg06064525 chr11:970664 AP2A2 -0.49 -16.53 -0.55 2.35e-51 Alzheimer's disease (late onset); BRCA cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg23422044 chr7:1970798 MAD1L1 -0.59 -10.66 -0.39 1.54e-24 Bipolar disorder; BRCA trans rs9784649 1.000 rs11738315 chr5:24967891 T/C cg08600765 chr20:34638493 LOC647979 -0.51 -8.4 -0.32 2.79e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10174077 0.687 rs4664491 chr2:152479986 C/T cg19508488 chr2:152266495 RIF1 0.46 8.97 0.33 3.28e-18 Squamous cell lung carcinoma; BRCA cis rs3008870 1.000 rs2815351 chr1:67477980 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 19.8 0.62 2.22e-68 Lymphocyte percentage of white cells; BRCA cis rs7267979 0.903 rs2474766 chr20:25246153 A/G cg08601574 chr20:25228251 PYGB 0.38 9.19 0.34 5.5e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs921968 0.565 rs7599365 chr2:219620566 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -11.03 -0.4 5.37e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg08888203 chr3:10149979 C3orf24 0.57 12.11 0.43 1.62e-30 Alzheimer's disease; BRCA cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.78 -0.36 3.92e-21 IgG glycosylation; BRCA cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.47 -8.37 -0.31 3.78e-16 Schizophrenia; BRCA cis rs3772130 0.923 rs4298081 chr3:121526037 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.91 0.4 1.63e-25 Cognitive performance; BRCA cis rs6484504 0.576 rs2447671 chr11:31334323 A/G cg06552810 chr11:31128660 NA -0.37 -8.41 -0.32 2.64e-16 Red blood cell count; BRCA cis rs61931739 0.534 rs10844816 chr12:34248533 C/A cg06521331 chr12:34319734 NA -0.66 -12.09 -0.43 1.83e-30 Morning vs. evening chronotype; BRCA cis rs61931739 0.500 rs11053194 chr12:34440841 A/G cg06521331 chr12:34319734 NA -0.52 -10.3 -0.38 4.16e-23 Morning vs. evening chronotype; BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg24531977 chr5:56204891 C5orf35 -0.85 -17.66 -0.57 4.01e-57 Initial pursuit acceleration; BRCA cis rs6901250 0.655 rs1398403 chr6:117122646 T/C cg12892004 chr6:117198278 RFX6 0.38 9.27 0.34 2.76e-19 C-reactive protein levels; BRCA cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.17 0.31 1.68e-15 Depression; BRCA cis rs7615952 0.604 rs9837847 chr3:125623919 G/A cg05084668 chr3:125655381 ALG1L -0.82 -11.52 -0.41 4.73e-28 Blood pressure (smoking interaction); BRCA cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg19678392 chr7:94953810 PON1 -0.43 -9.01 -0.34 2.41e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6120849 0.754 rs6120797 chr20:33606002 G/A cg24642439 chr20:33292090 TP53INP2 0.6 10.3 0.38 4.11e-23 Protein C levels; BRCA cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg11301795 chr4:187892539 NA 0.31 10.28 0.38 4.82e-23 Lobe attachment (rater-scored or self-reported); BRCA trans rs7615952 0.512 rs11921452 chr3:125359750 A/G cg07211511 chr3:129823064 LOC729375 -0.58 -10.71 -0.39 1.02e-24 Blood pressure (smoking interaction); BRCA cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg15605315 chr1:45957053 TESK2 0.49 10.13 0.37 1.81e-22 High light scatter reticulocyte count; BRCA cis rs13315871 0.929 rs9837903 chr3:58301906 A/T cg20936604 chr3:58311152 NA -0.67 -8.65 -0.32 4.09e-17 Cholesterol, total; BRCA cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg07828340 chr4:882639 GAK 1.03 12.36 0.44 1.34e-31 Intelligence (multi-trait analysis); BRCA cis rs2346177 0.875 rs6726089 chr2:46645480 T/C cg02822958 chr2:46747628 ATP6V1E2 0.4 8.22 0.31 1.11e-15 HDL cholesterol; BRCA cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg05868516 chr6:26286170 HIST1H4H 0.39 8.4 0.32 2.91e-16 Educational attainment; BRCA cis rs9633740 0.578 rs11185982 chr10:82305627 C/T cg01528321 chr10:82214614 TSPAN14 0.75 12.25 0.44 3.78e-31 Post bronchodilator FEV1; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.59 8.98 0.33 3.06e-18 Renal function-related traits (BUN); BRCA cis rs4742903 0.967 rs6479215 chr9:106885243 A/G cg14250997 chr9:106856677 SMC2 -0.37 -11.82 -0.42 2.78e-29 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 9.25 0.34 3.44e-19 Platelet count; BRCA cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg18196295 chr10:418757 DIP2C 0.46 10.96 0.4 9.86e-26 Psychosis in Alzheimer's disease; BRCA cis rs654351 0.572 rs556578 chr6:10388755 T/C cg04978078 chr6:10383147 NA -0.43 -8.33 -0.31 4.83e-16 Squamous cell lung carcinoma; BRCA cis rs977987 0.806 rs6564252 chr16:75388940 C/T cg03315344 chr16:75512273 CHST6 0.51 11.9 0.43 1.21e-29 Dupuytren's disease; BRCA cis rs4566357 0.595 rs2272203 chr2:227914655 C/G cg11843606 chr2:227700838 RHBDD1 -0.41 -9.15 -0.34 7.51e-19 Coronary artery disease; BRCA cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.82 0.36 2.73e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg27211696 chr2:191398769 TMEM194B -0.47 -10.73 -0.39 8.03e-25 Pulse pressure; BRCA cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg03146154 chr1:46216737 IPP 0.52 11.54 0.42 3.9e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg01262667 chr19:19385393 TM6SF2 0.39 9.83 0.36 2.47e-21 Tonsillectomy; BRCA cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06481639 chr22:41940642 POLR3H -0.53 -8.72 -0.33 2.42e-17 Vitiligo; BRCA cis rs870825 0.616 rs4610378 chr4:185624220 C/T cg04058563 chr4:185651563 MLF1IP -0.74 -16.9 -0.56 3.17e-53 Blood protein levels; BRCA cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg21361702 chr7:150065534 REPIN1 0.55 9.96 0.37 7.73e-22 Blood protein levels;Circulating chemerin levels; BRCA cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs35995292 0.534 rs7793692 chr7:38940580 G/C cg19327137 chr7:38886074 VPS41 0.38 12.61 0.45 1.02e-32 Subjective well-being (multi-trait analysis); BRCA cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg11644478 chr21:40555479 PSMG1 0.54 11.57 0.42 3.2e-28 Menarche (age at onset); BRCA cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg20701182 chr2:24300061 SF3B14 0.55 8.53 0.32 1.09e-16 Lymphocyte counts; BRCA cis rs61931739 0.534 rs11053075 chr12:34207009 A/G cg06521331 chr12:34319734 NA 0.66 12.31 0.44 2.08e-31 Morning vs. evening chronotype; BRCA cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg00071950 chr4:10020882 SLC2A9 0.53 12.54 0.44 2e-32 Bone mineral density; BRCA cis rs1577917 1.000 rs34106666 chr6:86676258 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.1 -0.43 1.73e-30 Response to antipsychotic treatment; BRCA cis rs6542838 0.702 rs6739176 chr2:99536846 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -9.29 -0.34 2.38e-19 Fear of minor pain; BRCA cis rs1568889 1.000 rs2354427 chr11:28049623 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.76 0.5 1.21e-42 Bipolar disorder; BRCA cis rs11585357 0.895 rs72633808 chr1:17618665 A/G cg08277548 chr1:17600880 PADI3 -0.75 -12.48 -0.44 4.02e-32 Hair shape; BRCA cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.17e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4481887 0.962 rs6587452 chr1:248485931 C/T cg00666640 chr1:248458726 OR2T12 0.34 9.11 0.34 1.03e-18 Common traits (Other); BRCA cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg05340658 chr4:99064831 C4orf37 0.61 14.6 0.5 6.82e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs36051895 0.623 rs10975033 chr9:5262567 C/T cg02405213 chr9:5042618 JAK2 -0.47 -9.01 -0.34 2.44e-18 Pediatric autoimmune diseases; BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.07 -0.43 2.4e-30 Gut microbiome composition (summer); BRCA cis rs3750965 0.959 rs11228490 chr11:68860872 C/G cg06818126 chr11:68850279 TPCN2 0.34 8.25 0.31 9.27e-16 Hair color; BRCA cis rs11608355 0.515 rs7976796 chr12:109928013 C/T cg05360138 chr12:110035743 NA 0.74 13.54 0.47 6.41e-37 Neuroticism; BRCA cis rs56104184 0.775 rs73061697 chr19:49400000 C/T cg21252483 chr19:49399788 TULP2 -0.51 -10.86 -0.39 2.46e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7264396 0.635 rs6060681 chr20:34506147 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.9 -0.51 2.56e-43 Total cholesterol levels; BRCA cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.97 0.37 7.53e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17401966 1.000 rs12136376 chr1:10296452 C/T cg03954927 chr1:10346856 KIF1B 0.44 13.05 0.46 1.08e-34 Hepatocellular carcinoma; BRCA cis rs6539267 0.748 rs1921953 chr12:106721012 C/T cg02476566 chr12:106696527 TCP11L2 0.43 8.03 0.3 4.6e-15 Tourette syndrome; BRCA cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -10.83 -0.39 3.37e-25 Chronic sinus infection; BRCA cis rs858239 0.699 rs1881201 chr7:23194013 C/T cg23682824 chr7:23144976 KLHL7 -0.32 -8.46 -0.32 1.81e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg08132940 chr7:1081526 C7orf50 -0.6 -8.99 -0.34 2.69e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7092929 0.574 rs10795050 chr10:3538655 C/G cg14308648 chr10:3568949 NA 0.44 9.97 0.37 7.59e-22 Coronary artery calcification; BRCA cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12826209 chr6:26865740 GUSBL1 0.59 10.4 0.38 1.65e-23 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.51 -9.11 -0.34 1.07e-18 Renal function-related traits (BUN); BRCA cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg17971929 chr21:40555470 PSMG1 0.6 14.01 0.48 4.36e-39 Cognitive function; BRCA cis rs870825 0.929 rs55746424 chr4:185589603 C/T cg04058563 chr4:185651563 MLF1IP 0.88 14.4 0.49 6.56e-41 Blood protein levels; BRCA cis rs7766436 0.848 rs2294828 chr6:22598018 G/A cg13666174 chr6:22585274 NA -0.48 -11.32 -0.41 3.22e-27 Coronary artery disease; BRCA cis rs708547 0.647 rs6843644 chr4:57891239 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.41 10.6 0.39 2.66e-24 Response to bleomycin (chromatid breaks); BRCA cis rs2430307 0.556 rs3930019 chr7:76541610 C/T cg15770687 chr7:76625569 PMS2L11 0.53 9.14 0.34 8.51e-19 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs13046373 0.562 rs12627602 chr21:32022924 G/A cg16431978 chr21:31797932 KRTAP13-3 0.35 8.98 0.33 2.89e-18 HDL cholesterol; BRCA cis rs2370759 1.000 rs79442609 chr10:32608749 C/T cg18270830 chr10:32634957 EPC1 0.58 9.98 0.37 6.64e-22 Sexual dysfunction (female); BRCA cis rs6435161 0.919 rs7566220 chr2:203594559 A/G cg18429434 chr2:203499731 FAM117B -0.46 -9.03 -0.34 1.95e-18 Total cholesterol levels; BRCA cis rs801193 1.000 rs10252765 chr7:66228732 C/G cg11764359 chr7:65958608 NA 0.64 14.21 0.49 5.32e-40 Aortic root size; BRCA cis rs1568889 1.000 rs9783281 chr11:28033786 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 14.35 0.49 1.07e-40 Bipolar disorder; BRCA trans rs2197308 0.765 rs7295711 chr12:37903631 C/T cg06521331 chr12:34319734 NA -0.54 -9.73 -0.36 5.73e-21 Morning vs. evening chronotype; BRCA cis rs6500602 0.929 rs6500603 chr16:4497537 G/C cg08645402 chr16:4508243 NA 0.4 9.47 0.35 5.3e-20 Schizophrenia; BRCA cis rs10046574 0.656 rs17403326 chr7:135194440 T/G cg27474649 chr7:135195673 CNOT4 0.66 10.84 0.39 2.93e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4839827 1 rs4839827 chr6:96853967 C/T cg06623918 chr6:96969491 KIAA0776 0.6 13.7 0.48 1.2e-37 Migraine; BRCA cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg02574844 chr11:5959923 NA -0.43 -9.68 -0.36 8.71e-21 DNA methylation (variation); BRCA trans rs2204008 0.653 rs11182569 chr12:38572452 G/A cg06521331 chr12:34319734 NA -0.5 -9.12 -0.34 9.82e-19 Bladder cancer; BRCA cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.94 -0.3 8.8e-15 Ulcerative colitis; BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg22903471 chr2:27725779 GCKR -0.35 -8.61 -0.32 5.83e-17 Total body bone mineral density; BRCA cis rs3733585 0.638 rs13145554 chr4:9979589 C/T cg00071950 chr4:10020882 SLC2A9 0.42 9.69 0.36 8.06e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10752881 0.935 rs10911235 chr1:183053746 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.73e-54 Colorectal cancer; BRCA cis rs7085104 0.591 rs4919683 chr10:104585125 G/T cg04362960 chr10:104952993 NT5C2 0.39 9.27 0.34 2.72e-19 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg03433033 chr1:76189801 ACADM -0.51 -10.11 -0.37 2.11e-22 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs61931739 0.534 rs1211286 chr12:34135581 T/C cg26384229 chr12:38710491 ALG10B 0.55 12.04 0.43 3.26e-30 Morning vs. evening chronotype; BRCA cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg08085267 chr17:45401833 C17orf57 0.67 14.9 0.51 2.68e-43 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11051970 0.679 rs2651366 chr12:32560431 T/C cg24626660 chr12:32551988 NA 0.31 9.18 0.34 5.82e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11229555 0.874 rs11601687 chr11:58338628 T/C cg15696309 chr11:58395628 NA -0.54 -11.75 -0.42 5.45e-29 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.51 -9.02 -0.34 2.22e-18 Schizophrenia; BRCA cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg23029597 chr12:123009494 RSRC2 -0.6 -11.78 -0.42 3.83e-29 Body mass index; BRCA cis rs7927771 0.524 rs2242081 chr11:47500267 T/C cg20307385 chr11:47447363 PSMC3 0.45 10.08 0.37 2.85e-22 Subjective well-being; BRCA cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08109568 chr15:31115862 NA -0.44 -10.26 -0.38 5.56e-23 Huntington's disease progression; BRCA trans rs11039798 0.844 rs11040177 chr11:48976211 G/C cg15704280 chr7:45808275 SEPT13 0.6 8.89 0.33 6.42e-18 Axial length; BRCA cis rs11190604 1.000 rs10883497 chr10:102228519 A/G cg07080220 chr10:102295463 HIF1AN 0.48 10.76 0.39 6.5e-25 Palmitoleic acid (16:1n-7) levels; BRCA trans rs2739330 0.828 rs4820572 chr22:24250355 T/C cg06437703 chr8:37914619 EIF4EBP1 -0.33 -8.51 -0.32 1.21e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1595825 0.945 rs73056880 chr2:198822292 G/A cg19156104 chr2:198669113 PLCL1 -0.44 -8.13 -0.31 2.19e-15 Ulcerative colitis; BRCA cis rs2243480 1.000 rs458291 chr7:65520479 C/A cg18252515 chr7:66147081 NA -0.97 -13.78 -0.48 5.15e-38 Diabetic kidney disease; BRCA cis rs600231 0.508 rs11227202 chr11:65242717 G/A cg01292856 chr11:65242576 NA 0.66 14.88 0.51 3.36e-43 Bone mineral density; BRCA cis rs17604090 0.775 rs73090343 chr7:29688768 T/C cg19413766 chr7:29689036 LOC646762 -0.61 -8.71 -0.33 2.53e-17 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg07395648 chr5:131743802 NA -0.38 -8.58 -0.32 6.98e-17 Breast cancer;Mosquito bite size; BRCA cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg12386194 chr3:101231763 SENP7 0.46 9.91 0.37 1.21e-21 Colorectal cancer; BRCA cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA trans rs208520 1.000 rs12216109 chr6:66987488 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.41 0.5 5.6e-41 Exhaled nitric oxide output; BRCA cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg24803719 chr17:45855879 NA -0.32 -8.35 -0.31 4.14e-16 IgG glycosylation; BRCA cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg01877450 chr7:97915802 BRI3 -0.37 -8.51 -0.32 1.24e-16 Prostate cancer (SNP x SNP interaction); BRCA trans rs6598955 0.671 rs7544 chr1:26607726 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs2629540 0.847 rs10901807 chr10:126384610 G/A cg08799069 chr10:126477246 METTL10 0.47 9.46 0.35 5.57e-20 Cocaine dependence; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12541635 0.677 rs7846149 chr8:107053417 T/C cg10147462 chr8:107024639 NA 0.4 10.83 0.39 3.22e-25 Age of smoking initiation; BRCA cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg19318889 chr4:1322082 MAEA 0.57 11.47 0.41 7.96e-28 Longevity; BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg27170947 chr2:26402098 FAM59B -0.97 -17.16 -0.56 1.38e-54 Gut microbiome composition (summer); BRCA cis rs1065852 0.526 rs4822079 chr22:42394612 G/C cg22189786 chr22:42395067 WBP2NL 0.43 8.68 0.32 3.29e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg03929089 chr4:120376271 NA 0.69 13.7 0.48 1.17e-37 Height; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg11843238 chr5:131593191 PDLIM4 0.42 10.58 0.39 3.1e-24 Acylcarnitine levels; BRCA cis rs12142240 0.698 rs7515284 chr1:46809419 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg24549020 chr5:56110836 MAP3K1 0.68 13.71 0.48 1.08e-37 Initial pursuit acceleration; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.954 rs10006525 chr4:120408931 T/G cg25517755 chr10:38738941 LOC399744 -0.37 -7.85 -0.3 1.73e-14 Corneal astigmatism; BRCA cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.09 -0.34 1.19e-18 Major depressive disorder; BRCA cis rs870825 0.929 rs10015218 chr4:185589789 T/C cg04058563 chr4:185651563 MLF1IP 0.68 11.52 0.41 4.92e-28 Blood protein levels; BRCA cis rs1534166 0.647 rs9876158 chr3:133508300 T/C cg01448562 chr3:133502909 NA 0.4 9.05 0.34 1.66e-18 Alcohol consumption (transferrin glycosylation); BRCA cis rs2554380 0.943 rs2401128 chr15:84347178 C/A cg14598478 chr15:84363061 ADAMTSL3 -0.32 -7.95 -0.3 8.2e-15 Height; BRCA cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg01819863 chr10:32635814 EPC1 1.16 20.46 0.63 6.39e-72 Sexual dysfunction (female); BRCA cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06544989 chr22:39130855 UNC84B -0.35 -8.22 -0.31 1.13e-15 Menopause (age at onset); BRCA cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg23583168 chr7:148888333 NA -0.72 -15.66 -0.53 5.3e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.02 0.3 4.91e-15 Corneal astigmatism; BRCA cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.5e-77 Mean platelet volume; BRCA cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 16.15 0.54 1.85e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7258465 1.000 rs34256197 chr19:18606472 G/A cg01065977 chr19:18549689 ISYNA1 -0.28 -8.23 -0.31 1.03e-15 Breast cancer; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg07092213 chr7:1199455 ZFAND2A -0.49 -10.68 -0.39 1.27e-24 Longevity;Endometriosis; BRCA cis rs6582630 0.519 rs80226845 chr12:38528231 C/A cg13010199 chr12:38710504 ALG10B 0.52 10.93 0.4 1.28e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs2282802 0.685 rs1529693 chr5:139678213 A/G cg26211634 chr5:139558579 C5orf32 0.32 7.81 0.3 2.36e-14 Intelligence (multi-trait analysis); BRCA cis rs3892630 0.588 rs12610342 chr19:33250690 C/T cg22980127 chr19:33182716 NUDT19 0.9 19.76 0.62 3.56e-68 Red blood cell traits; BRCA trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg00717180 chr2:96193071 NA -0.38 -10.34 -0.38 2.9e-23 HDL cholesterol; BRCA cis rs208520 1.000 rs12193077 chr6:66989548 C/T cg07460842 chr6:66804631 NA 0.88 14.18 0.49 7.35e-40 Exhaled nitric oxide output; BRCA cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs4730250 0.707 rs80095766 chr7:106901394 G/T cg02696742 chr7:106810147 HBP1 -0.47 -8.34 -0.31 4.62e-16 Osteoarthritis; BRCA cis rs67340775 0.541 rs169287 chr6:27854760 C/A cg26587870 chr6:27730563 NA -0.44 -7.91 -0.3 1.17e-14 Lung cancer in ever smokers; BRCA trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg00717180 chr2:96193071 NA -0.38 -10.34 -0.38 2.9e-23 HDL cholesterol; BRCA cis rs2992756 0.663 rs2992753 chr1:18808292 A/C cg14356550 chr1:18808102 KLHDC7A 0.41 8.55 0.32 9.35e-17 Breast cancer; BRCA cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg13319975 chr6:146136371 FBXO30 -0.36 -8.28 -0.31 7.48e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg20503657 chr10:835505 NA -0.92 -15.58 -0.52 1.21e-46 Eosinophil percentage of granulocytes; BRCA cis rs1008375 0.966 rs7675735 chr4:17587137 T/A cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.66 -0.32 3.97e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs999943 0.810 rs57088429 chr6:33644189 G/A cg14003231 chr6:33640908 ITPR3 0.68 14.92 0.51 1.99e-43 Obesity (extreme); BRCA cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 0.78 19.37 0.61 4.37e-66 Systemic lupus erythematosus; BRCA cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 8.98 0.33 3.02e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12579753 0.879 rs11615729 chr12:82128318 T/A cg07988820 chr12:82153109 PPFIA2 -0.68 -11.44 -0.41 1.05e-27 Resting heart rate; BRCA cis rs921968 0.541 rs72965126 chr2:219330189 C/T cg10223061 chr2:219282414 VIL1 0.3 8.55 0.32 8.83e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg12463550 chr7:65579703 CRCP 0.38 8.02 0.3 5.21e-15 Aortic root size; BRCA cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.52e-16 Developmental language disorder (linguistic errors); BRCA cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg01939980 chr4:1354348 KIAA1530 0.31 8.27 0.31 7.87e-16 Obesity-related traits; BRCA cis rs9291683 0.692 rs1558489 chr4:10325489 T/A cg00071950 chr4:10020882 SLC2A9 -0.43 -9.95 -0.37 8.55e-22 Bone mineral density; BRCA cis rs1372520 0.873 rs983361 chr4:90761944 T/G cg15133208 chr4:90757351 SNCA -0.41 -8.58 -0.32 7.38e-17 Neuroticism; BRCA cis rs3820928 0.904 rs4414671 chr2:227816200 T/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.7 -0.33 2.7e-17 Pulmonary function; BRCA cis rs561341 1.000 rs576985 chr17:30323323 C/T cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.58e-17 Hip circumference adjusted for BMI; BRCA cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg21770322 chr7:97807741 LMTK2 0.41 10.94 0.4 1.14e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs36051895 0.659 rs62541556 chr9:5049092 G/T cg02405213 chr9:5042618 JAK2 -0.51 -9.11 -0.34 1.02e-18 Pediatric autoimmune diseases; BRCA cis rs9790314 0.934 rs461638 chr3:161103166 A/G cg03342759 chr3:160939853 NMD3 -0.61 -12.8 -0.45 1.41e-33 Morning vs. evening chronotype; BRCA cis rs4363385 0.720 rs1611755 chr1:152956420 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.99 -0.33 2.87e-18 Inflammatory skin disease; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.47 9.68 0.36 8.89e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg06552810 chr11:31128660 NA -0.4 -8.82 -0.33 1.09e-17 Red blood cell count; BRCA cis rs6867032 1.000 rs4975796 chr5:2015520 A/T cg26168224 chr5:2018326 NA -0.63 -16.69 -0.55 3.66e-52 Gut microbiome composition (winter); BRCA cis rs17270561 0.609 rs12203927 chr6:25732690 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs62229266 0.804 rs2835241 chr21:37411380 G/T cg12218747 chr21:37451666 NA 0.33 7.88 0.3 1.42e-14 Mitral valve prolapse; BRCA cis rs7306456 0.623 rs10902513 chr12:132693487 A/G cg07640336 chr12:132677496 NA 0.49 11.27 0.41 5.13e-27 Anti-saccade response; BRCA cis rs870825 0.587 rs7682995 chr4:185640684 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.18 0.56 1.08e-54 Blood protein levels; BRCA cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg26373071 chr5:1325741 CLPTM1L 0.46 11.11 0.4 2.44e-26 Lung cancer; BRCA cis rs3784262 0.935 rs4646636 chr15:58251034 A/G cg12031962 chr15:58353849 ALDH1A2 -0.43 -11.61 -0.42 2.06e-28 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4660306 1.000 rs7534467 chr1:45988691 G/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.96 -0.3 8.12e-15 Homocysteine levels; BRCA cis rs250677 0.687 rs250674 chr5:148438597 A/G cg18129178 chr5:148520854 ABLIM3 0.58 11.94 0.43 8.25e-30 Breast cancer; BRCA cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg24562669 chr7:97807699 LMTK2 0.44 11.74 0.42 5.96e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4662945 0.603 rs10168574 chr2:130267823 C/T cg05903289 chr2:130345205 NA -0.34 -8.29 -0.31 6.57e-16 Response to cytidine analogues (gemcitabine); BRCA cis rs7085104 0.632 rs6162 chr10:104596981 G/A cg04362960 chr10:104952993 NT5C2 0.39 9.37 0.35 1.18e-19 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs2625529 0.590 rs12904652 chr15:72548765 T/C cg16672083 chr15:72433130 SENP8 -0.66 -14.5 -0.5 2.04e-41 Red blood cell count; BRCA cis rs1200821 0.535 rs1208783 chr10:37767467 A/G cg25427524 chr10:38739819 LOC399744 -0.44 -9.28 -0.34 2.68e-19 Hemostatic factors and hematological phenotypes; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg04166393 chr7:2884313 GNA12 0.49 9.86 0.36 1.97e-21 Height; BRCA cis rs2075371 0.932 rs2241332 chr7:133969439 A/G cg02659138 chr7:134003124 SLC35B4 0.35 10.01 0.37 5.01e-22 Mean platelet volume; BRCA cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2046867 0.818 rs17690720 chr3:72866030 T/C cg25664220 chr3:72788482 NA -0.55 -11.73 -0.42 6.4e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.49 11.31 0.41 3.65e-27 Chronic sinus infection; BRCA cis rs9457247 0.638 rs239933 chr6:167413230 A/G cg23791538 chr6:167370224 RNASET2 -0.35 -8.24 -0.31 9.57e-16 Crohn's disease; BRCA cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.8 0.36 3.11e-21 Bipolar disorder; BRCA trans rs8002861 0.870 rs2875541 chr13:44417441 G/T cg17145862 chr1:211918768 LPGAT1 0.62 15.9 0.53 3.33e-48 Leprosy; BRCA cis rs72781680 0.848 rs715646 chr2:24010566 G/A cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg00631329 chr6:26305371 NA -0.45 -13.04 -0.46 1.23e-34 Educational attainment; BRCA cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg18964960 chr10:1102726 WDR37 0.65 8.71 0.33 2.69e-17 Eosinophil percentage of granulocytes; BRCA cis rs501916 0.634 rs1561480 chr15:48070050 C/G cg16110827 chr15:48056943 SEMA6D -0.41 -8.71 -0.33 2.68e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs17253792 0.822 rs28481586 chr14:56053863 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.57 7.98 0.3 6.98e-15 Putamen volume; BRCA cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg10932868 chr11:921992 NA 0.49 12.57 0.45 1.54e-32 Alzheimer's disease (late onset); BRCA cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg15839431 chr19:19639596 YJEFN3 -0.4 -8.6 -0.32 6.25e-17 Bipolar disorder; BRCA cis rs7582180 0.652 rs11675901 chr2:100951189 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.56 0.42 3.53e-28 Intelligence (multi-trait analysis); BRCA cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.51 0.52 2.68e-46 Colorectal cancer; BRCA cis rs8062405 1.000 rs56358680 chr16:28843118 A/G cg16576597 chr16:28551801 NUPR1 0.3 8.32 0.31 5.25e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10501293 1.000 rs4495880 chr11:43133626 A/C cg03447554 chr11:43094025 NA -0.47 -8.66 -0.32 3.84e-17 Cognitive performance; BRCA cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg18016565 chr1:150552671 MCL1 0.35 8.36 0.31 3.9e-16 Tonsillectomy; BRCA cis rs654128 0.590 rs339346 chr6:117218693 T/G cg12892004 chr6:117198278 RFX6 -0.42 -7.82 -0.3 2.2e-14 Telomere length; BRCA cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.3 8.23 0.31 1.08e-15 Birth weight; BRCA cis rs2279817 0.863 rs12023877 chr1:18025633 A/C cg21791023 chr1:18019539 ARHGEF10L 0.51 15.94 0.53 2.01e-48 Neuroticism; BRCA trans rs17685 0.753 rs7804598 chr7:75702578 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 27.58 0.74 6.51e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg05707623 chr12:122985044 ZCCHC8 -0.44 -9.05 -0.34 1.67e-18 Body mass index; BRCA cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg03146154 chr1:46216737 IPP 0.53 11.8 0.42 3.38e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg16339924 chr4:17578868 LAP3 0.62 15.6 0.53 9.9e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs61935443 0.720 rs10859780 chr12:95282601 T/C cg21533806 chr12:95267307 NA 0.45 8.65 0.32 4.09e-17 Schizophrenia; BRCA cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08704250 chr15:31115839 NA -0.36 -9.07 -0.34 1.42e-18 Huntington's disease progression; BRCA trans rs7786808 0.741 rs35059736 chr7:158224692 C/T cg02030672 chr11:45687055 CHST1 0.42 8.72 0.33 2.47e-17 Obesity-related traits; BRCA cis rs11690935 0.959 rs10166005 chr2:172607294 C/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.6 -0.77 2.62e-127 Schizophrenia; BRCA cis rs2304069 0.954 rs9324638 chr5:149400718 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.84 -17.06 -0.56 4.79e-54 HIV-1 control; BRCA cis rs9287719 0.901 rs13034017 chr2:10739592 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -9.09 -0.34 1.21e-18 Breast cancer; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg05457628 chr5:178986728 RUFY1 -0.54 -13.42 -0.47 2.27e-36 Lung cancer; BRCA cis rs4718428 0.705 rs2901311 chr7:66415069 T/C cg12165864 chr7:66369176 NA -0.43 -9.22 -0.34 4.39e-19 Corneal structure; BRCA cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg23583168 chr7:148888333 NA -0.86 -20.09 -0.62 5.61e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9311474 1.000 rs2276834 chr3:52325759 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.25 7.84 0.3 1.96e-14 Electroencephalogram traits; BRCA cis rs7149337 0.805 rs2999361 chr14:51605358 G/A cg23942311 chr14:51606299 NA 0.45 13.26 0.46 1.21e-35 Cancer; BRCA cis rs2742234 0.541 rs10793424 chr10:43717116 G/T cg15436174 chr10:43711423 RASGEF1A 0.53 10.6 0.39 2.8e-24 Hirschsprung disease; BRCA cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg17143192 chr8:8559678 CLDN23 0.5 9.7 0.36 7.32e-21 Obesity-related traits; BRCA cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg12311346 chr5:56204834 C5orf35 -0.62 -13.08 -0.46 7.94e-35 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg05340658 chr4:99064831 C4orf37 0.66 16.19 0.54 1.17e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.525 rs3914597 chr12:39388693 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.44 0.35 6.82e-20 Morning vs. evening chronotype; BRCA cis rs2652822 0.525 rs2053633 chr15:63505649 G/A cg02713581 chr15:63449717 RPS27L 0.41 8.3 0.31 6.15e-16 Metabolic traits; BRCA cis rs7903847 0.667 rs10882931 chr10:99165794 C/A cg08345082 chr10:99160200 RRP12 -0.3 -8.78 -0.33 1.44e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs17685 0.753 rs2868203 chr7:75680026 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.4 8.92 0.33 4.92e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs250677 0.687 rs250664 chr5:148453823 C/T cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.84e-31 Breast cancer; BRCA cis rs4481887 1.000 rs4579792 chr1:248463742 C/T cg00666640 chr1:248458726 OR2T12 -0.32 -8.6 -0.32 6.37e-17 Common traits (Other); BRCA trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg11887960 chr12:57824829 NA 0.56 8.66 0.32 3.7e-17 Lung disease severity in cystic fibrosis; BRCA cis rs4808199 0.649 rs17216693 chr19:19666574 T/C cg03709012 chr19:19516395 GATAD2A 0.76 12.43 0.44 6.66e-32 Nonalcoholic fatty liver disease; BRCA cis rs6912958 1.000 rs9294379 chr6:88152535 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -9.27 -0.34 2.76e-19 Monocyte percentage of white cells; BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg02951883 chr7:2050386 MAD1L1 -0.41 -9.58 -0.35 2.07e-20 Bipolar disorder and schizophrenia; BRCA cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -12.23 -0.44 4.82e-31 Electroencephalogram traits; BRCA cis rs17384381 1.000 rs12118950 chr1:85864519 T/C cg16011679 chr1:85725395 C1orf52 0.53 8.15 0.31 1.86e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.609 rs7678012 chr4:9993772 T/C cg02734326 chr4:10020555 SLC2A9 0.37 8.32 0.31 5.16e-16 Bone mineral density; BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg27170947 chr2:26402098 FAM59B 0.99 15.28 0.52 3.79e-45 Gut microbiome composition (summer); BRCA cis rs6088813 0.961 rs745931 chr20:33956004 A/T cg14752227 chr20:34000481 UQCC -0.39 -8.4 -0.32 2.82e-16 Height; BRCA cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg14343924 chr8:8086146 FLJ10661 -0.47 -9.45 -0.35 6.39e-20 Neuroticism; BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg03609598 chr5:56110824 MAP3K1 -0.47 -8.01 -0.3 5.6e-15 Initial pursuit acceleration; BRCA cis rs10189230 0.868 rs1367242 chr2:222353441 A/G cg14652038 chr2:222343519 EPHA4 0.47 13.02 0.46 1.53e-34 Urate levels in lean individuals; BRCA cis rs875971 0.522 rs709604 chr7:65497434 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -9.0 -0.34 2.62e-18 Aortic root size; BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg04944784 chr2:26401820 FAM59B -0.64 -10.66 -0.39 1.61e-24 Gut microbiome composition (summer); BRCA cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.52 0.77 6.7e-127 Chronic sinus infection; BRCA cis rs9467773 0.626 rs9379860 chr6:26370605 T/C cg09904177 chr6:26538194 HMGN4 -0.32 -8.74 -0.33 2.11e-17 Intelligence (multi-trait analysis); BRCA trans rs2797160 0.967 rs2797162 chr6:126011381 G/T cg05039488 chr6:79577232 IRAK1BP1 0.36 8.07 0.3 3.49e-15 Endometrial cancer; BRCA cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg26597838 chr10:835615 NA -0.5 -9.42 -0.35 7.83e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.95e-38 Mean platelet volume; BRCA cis rs10927875 0.541 rs1763596 chr1:16343835 C/T cg06159980 chr1:16340746 HSPB7 -0.36 -8.29 -0.31 6.63e-16 Dilated cardiomyopathy; BRCA cis rs1215050 0.791 rs503863 chr4:98707663 T/C cg05340658 chr4:99064831 C4orf37 0.45 10.41 0.38 1.48e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg14004847 chr7:1930337 MAD1L1 -0.43 -8.56 -0.32 8.5e-17 Bipolar disorder and schizophrenia; BRCA cis rs77106637 0.860 rs1552224 chr11:72433098 A/C cg03713592 chr11:72463424 ARAP1 1.15 16.93 0.56 2.09e-53 Type 2 diabetes; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg25036284 chr2:26402008 FAM59B 0.96 15.93 0.53 2.36e-48 Gut microbiome composition (summer); BRCA cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg00745463 chr17:30367425 LRRC37B -0.55 -9.24 -0.34 3.7e-19 Hip circumference adjusted for BMI; BRCA cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.74 -0.45 2.61e-33 Bipolar disorder; BRCA cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.8 0.39 4.34e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9309473 0.687 rs12465867 chr2:73612102 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -12.35 -0.44 1.4e-31 Metabolite levels; BRCA cis rs11098499 0.954 rs7654587 chr4:120388406 C/T cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs7829975 0.573 rs7842359 chr8:8797078 T/G cg15556689 chr8:8085844 FLJ10661 -0.41 -11.16 -0.4 1.56e-26 Mood instability; BRCA cis rs6964587 0.692 rs4729025 chr7:91847504 C/T cg17063962 chr7:91808500 NA 0.57 13.08 0.46 8.24e-35 Breast cancer; BRCA cis rs7582720 0.945 rs72934601 chr2:204031137 G/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.25 0.44 3.99e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.48 11.0 0.4 7.07e-26 Colorectal cancer; BRCA cis rs6598955 0.671 rs11247893 chr1:26597086 A/C cg04990556 chr1:26633338 UBXN11 -0.51 -8.39 -0.31 3.18e-16 Obesity-related traits; BRCA cis rs5758511 0.689 rs55906806 chr22:42644471 C/T cg00645731 chr22:42541494 CYP2D7P1 0.53 8.33 0.31 4.76e-16 Birth weight; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.74 0.33 2.07e-17 Platelet count; BRCA trans rs9388451 0.536 rs34725880 chr6:126155237 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.4 -8.7 -0.33 2.8e-17 Brugada syndrome; BRCA cis rs9486719 1.000 rs12208884 chr6:96885572 G/A cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.7200000000000002e-34 Migraine;Coronary artery disease; BRCA cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.36 7.9 0.3 1.25e-14 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 18.26 0.59 2.77e-60 Platelet count; BRCA cis rs4925386 0.840 rs6143035 chr20:60920700 C/T cg24112000 chr20:60950667 NA 0.48 9.37 0.35 1.22e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.72 0.5 1.88e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs938554 0.513 rs3775948 chr4:9995182 G/C cg00071950 chr4:10020882 SLC2A9 0.4 8.52 0.32 1.19e-16 Blood metabolite levels; BRCA cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.39 -0.44 9.32e-32 Chronic sinus infection; BRCA cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg01939980 chr4:1354348 KIAA1530 0.31 8.66 0.32 3.72e-17 Longevity; BRCA cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19346786 chr7:2764209 NA -0.26 -8.01 -0.3 5.46e-15 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs514406 0.505 rs269290 chr1:53167027 A/T cg24675658 chr1:53192096 ZYG11B -0.6 -14.06 -0.49 2.65e-39 Monocyte count; BRCA cis rs600806 0.815 rs4970730 chr1:109979526 T/C cg20591472 chr1:110008990 SYPL2 0.32 7.89 0.3 1.34e-14 Intelligence (multi-trait analysis); BRCA cis rs208520 0.690 rs12213928 chr6:66762978 G/A cg07460842 chr6:66804631 NA 1.0 20.0 0.62 1.76e-69 Exhaled nitric oxide output; BRCA cis rs36052053 0.908 rs13220206 chr6:109624481 G/T cg12927641 chr6:109611667 NA -0.51 -7.96 -0.3 7.92e-15 Red cell distribution width; BRCA cis rs10992471 0.603 rs12336884 chr9:95234183 A/C cg14631576 chr9:95140430 CENPP -0.38 -9.31 -0.35 2.01e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs698833 0.561 rs696597 chr2:44722553 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.44 8.02 0.3 5.16e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg26314531 chr2:26401878 FAM59B 0.89 15.87 0.53 4.58e-48 Gut microbiome composition (summer); BRCA cis rs8141797 0.901 rs5751804 chr22:24490105 A/C cg00411358 chr22:24577142 SUSD2 0.63 7.9 0.3 1.21e-14 Amyotrophic lateral sclerosis;Coronary artery disease; BRCA trans rs4332037 0.615 rs62435127 chr7:1884937 A/G cg11693508 chr17:37793320 STARD3 0.59 11.0 0.4 6.74e-26 Bipolar disorder; BRCA cis rs4363385 0.747 rs1338180 chr1:152981404 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.86 -0.36 1.92e-21 Inflammatory skin disease; BRCA cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg25382214 chr1:3105252 PRDM16 -0.34 -8.03 -0.3 4.54e-15 Migraine; BRCA cis rs365132 0.934 rs251844 chr5:176476605 T/A cg16309518 chr5:176445507 NA -0.51 -13.0 -0.46 1.86e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs6700896 0.931 rs4655764 chr1:66126159 C/T cg04111102 chr1:66153794 NA 0.34 8.46 0.32 1.88e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg21475434 chr5:93447410 FAM172A 0.61 8.26 0.31 8.26e-16 Diabetic retinopathy; BRCA cis rs7255436 0.931 rs7249520 chr19:8446056 G/A cg10174797 chr19:8464628 RAB11B 0.35 8.91 0.33 5.31e-18 HDL cholesterol; BRCA trans rs7647973 0.593 rs28535523 chr3:49848414 C/T cg21659725 chr3:3221576 CRBN 0.48 8.84 0.33 9.32e-18 Menarche (age at onset); BRCA cis rs10193935 0.901 rs7601905 chr2:42494144 A/G cg27598129 chr2:42591480 NA -0.55 -9.31 -0.35 2.08e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs698813 0.763 rs786614 chr2:44590567 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.57 11.02 0.4 5.64e-26 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00149659 chr3:10157352 C3orf10 0.81 14.21 0.49 5.29e-40 Alzheimer's disease; BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg11766577 chr21:47581405 C21orf56 -0.48 -10.88 -0.4 2.15e-25 Testicular germ cell tumor; BRCA cis rs709400 0.628 rs6575983 chr14:103869849 C/G cg26031613 chr14:104095156 KLC1 0.65 14.23 0.49 3.94e-40 Body mass index; BRCA cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg23711669 chr6:146136114 FBXO30 -0.78 -18.28 -0.59 2.24e-60 Lobe attachment (rater-scored or self-reported); BRCA cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg01097406 chr16:89675127 NA -0.46 -8.56 -0.32 8.6e-17 Vitiligo; BRCA cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg00409905 chr10:38381863 ZNF37A -0.49 -10.22 -0.37 8.51e-23 Extrinsic epigenetic age acceleration; BRCA cis rs17270561 0.609 rs6924794 chr6:25735874 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg19077165 chr18:44547161 KATNAL2 -0.56 -12.25 -0.44 3.83e-31 Personality dimensions; BRCA cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg02187348 chr16:89574699 SPG7 0.37 8.67 0.32 3.42e-17 Multiple myeloma (IgH translocation); BRCA cis rs9649213 0.593 rs6949214 chr7:97960233 G/A cg21770322 chr7:97807741 LMTK2 0.44 11.74 0.42 6.15e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg16339924 chr4:17578868 LAP3 0.68 16.62 0.55 8.17e-52 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7020830 0.898 rs2047010 chr9:37077947 A/G cg14294708 chr9:37120828 ZCCHC7 1.16 40.09 0.85 1.44e-176 Schizophrenia; BRCA cis rs9814567 0.806 rs4955534 chr3:134319723 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs13102973 0.867 rs4521398 chr4:135906934 T/G cg14419869 chr4:135874104 NA 0.45 8.99 0.34 2.75e-18 Subjective well-being; BRCA trans rs9329221 0.686 rs35840352 chr8:10239807 A/G cg06636001 chr8:8085503 FLJ10661 0.54 10.57 0.39 3.58e-24 Neuroticism; BRCA cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.67 -0.32 3.64e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6121246 0.609 rs6089054 chr20:30323141 A/G cg13852791 chr20:30311386 BCL2L1 0.84 18.23 0.58 4.23e-60 Mean corpuscular hemoglobin; BRCA cis rs9814567 1.000 rs9968172 chr3:134231251 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.68 0.61 9.03e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7301826 0.627 rs4334059 chr12:131314214 T/C cg11011512 chr12:131303247 STX2 0.46 11.63 0.42 1.75e-28 Plasma plasminogen activator levels; BRCA cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg22467129 chr15:76604101 ETFA -0.48 -10.55 -0.39 4.25e-24 Blood metabolite levels; BRCA cis rs10465746 0.752 rs10874426 chr1:84451820 A/G cg10977910 chr1:84465055 TTLL7 0.62 13.37 0.47 4.14e-36 Obesity-related traits; BRCA cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg24562669 chr7:97807699 LMTK2 -0.5 -13.87 -0.48 2.09e-38 Breast cancer; BRCA cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg03161606 chr19:29218774 NA 0.46 8.04 0.3 4.23e-15 Methadone dose in opioid dependence; BRCA cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg05340658 chr4:99064831 C4orf37 0.66 16.1 0.54 3.26e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs6545883 0.862 rs778141 chr2:61682178 A/G cg15711740 chr2:61764176 XPO1 -0.52 -12.47 -0.44 4.25e-32 Tuberculosis; BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg22903471 chr2:27725779 GCKR -0.36 -8.43 -0.32 2.35e-16 Total body bone mineral density; BRCA cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg24642439 chr20:33292090 TP53INP2 -0.52 -11.42 -0.41 1.3e-27 Glomerular filtration rate (creatinine); BRCA cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg08645402 chr16:4508243 NA 0.43 9.87 0.36 1.8e-21 Schizophrenia; BRCA cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg17971929 chr21:40555470 PSMG1 -0.63 -14.03 -0.49 3.54e-39 Cognitive function; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg22907277 chr7:1156413 C7orf50 0.46 10.79 0.39 4.75e-25 Longevity;Endometriosis; BRCA cis rs4713118 0.621 rs4713132 chr6:28034035 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.1 0.31 2.83e-15 Parkinson's disease; BRCA cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg11062466 chr8:58055876 NA 0.51 12.34 0.44 1.54e-31 Developmental language disorder (linguistic errors); BRCA cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 17.15 0.56 1.55e-54 Age-related macular degeneration (geographic atrophy); BRCA cis rs3806843 0.766 rs801399 chr5:140034844 C/T cg11822812 chr5:140052017 DND1 -0.32 -9.02 -0.34 2.19e-18 Depressive symptoms (multi-trait analysis); BRCA cis rs10751667 0.666 rs10902235 chr11:938892 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA trans rs11165623 0.564 rs6593611 chr1:97001996 T/C cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.18e-30 Hip circumference;Waist circumference; BRCA cis rs9325144 0.513 rs12313652 chr12:38665412 G/A cg26384229 chr12:38710491 ALG10B -0.55 -13.72 -0.48 9.53e-38 Morning vs. evening chronotype; BRCA cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg20090143 chr19:45452003 APOC2 0.27 7.89 0.3 1.31e-14 Blood protein levels; BRCA cis rs344364 0.511 rs1742472 chr16:1953040 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.46 -8.33 -0.31 5.03e-16 Glomerular filtration rate in chronic kidney disease; BRCA cis rs60843830 0.661 rs55987018 chr2:106655 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.64 0.32 4.61e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg04166393 chr7:2884313 GNA12 0.42 9.03 0.34 2.02e-18 Height; BRCA cis rs68170813 0.559 rs80212020 chr7:106957596 C/T cg02696742 chr7:106810147 HBP1 -0.54 -8.67 -0.32 3.66e-17 Coronary artery disease; BRCA cis rs7267979 1.000 rs11100 chr20:25281184 G/C cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.63e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg06766960 chr11:133703094 NA -0.61 -12.64 -0.45 7.67e-33 Childhood ear infection; BRCA cis rs9790314 1.000 rs4597724 chr3:160963110 A/G cg03342759 chr3:160939853 NMD3 -0.64 -13.71 -0.48 1.08e-37 Morning vs. evening chronotype; BRCA cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.42 -0.38 1.38e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs4650994 0.507 rs12405456 chr1:178512331 T/G cg05059571 chr16:84539110 KIAA1609 -0.57 -13.03 -0.46 1.41e-34 HDL cholesterol levels;HDL cholesterol; BRCA cis rs2882667 0.690 rs13181762 chr5:138250106 G/A cg04439458 chr5:138467593 SIL1 -0.32 -8.03 -0.3 4.61e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.72e-31 Breast cancer; BRCA cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg13902645 chr11:5959945 NA -0.57 -11.47 -0.41 8.11e-28 DNA methylation (variation); BRCA cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.2 0.73 7.83e-109 Chronic sinus infection; BRCA cis rs7727544 0.716 rs2089855 chr5:131573529 A/G cg14196790 chr5:131705035 SLC22A5 0.44 11.54 0.42 4.09e-28 Blood metabolite levels; BRCA cis rs7582180 0.627 rs6749018 chr2:101001859 G/T cg14675211 chr2:100938903 LONRF2 0.44 10.04 0.37 3.87e-22 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.694 rs11179394 chr12:38210389 A/G cg26384229 chr12:38710491 ALG10B -0.45 -10.21 -0.37 8.93e-23 Bladder cancer; BRCA cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg11764359 chr7:65958608 NA 0.45 8.66 0.32 3.7e-17 Calcium levels; BRCA cis rs875971 0.862 rs12537823 chr7:65720884 C/T cg18876405 chr7:65276391 NA 0.5 11.38 0.41 1.89e-27 Aortic root size; BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg00814883 chr7:100076585 TSC22D4 -0.51 -11.67 -0.42 1.17e-28 Platelet count; BRCA cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg21475434 chr5:93447410 FAM172A 0.66 8.71 0.33 2.68e-17 Diabetic retinopathy; BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg13047869 chr3:10149882 C3orf24 0.55 11.42 0.41 1.25e-27 Alzheimer's disease; BRCA cis rs853679 0.517 rs9393885 chr6:28050009 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Depression; BRCA cis rs9287719 0.967 rs4405729 chr2:10755779 A/G cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4595586 0.525 rs12809307 chr12:39365927 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.39e-19 Morning vs. evening chronotype; BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg08280861 chr8:58055591 NA 0.57 8.82 0.33 1.11e-17 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs41294478 chr1:46818442 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs11112613 0.775 rs7959699 chr12:105959848 C/A cg03607813 chr12:105948248 NA 0.53 9.93 0.37 1.01e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs312274 0.588 rs11178530 chr12:41211874 G/C cg17827154 chr12:41323612 CNTN1 0.32 7.9 0.3 1.2e-14 Metabolite levels (X-11787); BRCA cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg10802521 chr3:52805072 NEK4 -0.33 -8.91 -0.33 5.38e-18 Bipolar disorder; BRCA cis rs9815354 0.638 rs73073258 chr3:42017894 G/A cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7520050 0.966 rs4660317 chr1:46326226 G/A cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs6088813 1.000 rs6060401 chr20:34005214 C/T cg14752227 chr20:34000481 UQCC -0.37 -7.85 -0.3 1.81e-14 Height; BRCA cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.580 rs7396041 chr11:1001607 G/A ch.11.42038R chr11:967971 AP2A2 0.45 13.68 0.48 1.47e-37 Alzheimer's disease (late onset); BRCA cis rs57920188 0.537 rs4440829 chr1:4080780 A/G cg10510935 chr1:4059661 NA -0.38 -8.08 -0.3 3.15e-15 Interleukin-17 levels; BRCA cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg08085267 chr17:45401833 C17orf57 0.68 14.87 0.51 3.69e-43 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs7647973 0.626 rs12715437 chr3:49751856 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.11 -0.31 2.66e-15 Menarche (age at onset); BRCA cis rs151349 0.743 rs151353 chr20:57604343 A/C cg23907860 chr20:57583709 CTSZ -0.37 -8.71 -0.33 2.67e-17 Platelet distribution width; BRCA cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg21427119 chr20:30132790 HM13 -0.42 -8.83 -0.33 9.87e-18 Mean corpuscular hemoglobin; BRCA cis rs495337 0.965 rs12151879 chr20:48549242 C/T cg17835207 chr20:48524531 SPATA2 -0.65 -15.14 -0.51 1.87e-44 Psoriasis; BRCA cis rs2415984 0.622 rs28487986 chr14:46924435 T/G cg14871534 chr14:47121158 RPL10L -0.35 -8.3 -0.31 6.1e-16 Number of children ever born; BRCA cis rs1595825 0.945 rs6736825 chr2:198854224 C/T cg19156104 chr2:198669113 PLCL1 -0.44 -8.15 -0.31 1.99e-15 Ulcerative colitis; BRCA cis rs867371 0.722 rs8033050 chr15:82561989 G/A cg00614314 chr15:82944287 LOC80154 0.47 9.63 0.36 1.42e-20 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs9325144 0.602 rs10785590 chr12:38694145 C/T cg26384229 chr12:38710491 ALG10B 0.54 13.71 0.48 1.05e-37 Morning vs. evening chronotype; BRCA cis rs796364 0.901 rs13030683 chr2:201061535 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 8.32 0.31 5.24e-16 Schizophrenia; BRCA cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11644478 chr21:40555479 PSMG1 0.81 18.1 0.58 1.96e-59 Cognitive function; BRCA cis rs2637266 0.935 rs4520537 chr10:78392978 C/T cg18941641 chr10:78392320 NA 0.37 8.38 0.31 3.39e-16 Pulmonary function; BRCA cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg22974920 chr21:40686053 BRWD1 -0.39 -8.71 -0.33 2.52e-17 Cognitive function; BRCA cis rs2806561 0.765 rs2806557 chr1:23503372 T/A cg12483005 chr1:23474871 LUZP1 0.47 10.17 0.37 1.33e-22 Height; BRCA cis rs2777491 1.000 rs7177641 chr15:41743426 C/T cg18705301 chr15:41695430 NDUFAF1 -0.65 -15.6 -0.53 1e-46 Ulcerative colitis; BRCA cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg08213375 chr14:104286397 PPP1R13B 0.64 18.05 0.58 3.45e-59 Schizophrenia; BRCA cis rs2764980 1.000 rs2814925 chr10:3284061 A/G cg11630169 chr10:3283847 NA -0.42 -9.53 -0.35 3.13e-20 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs2882667 0.690 rs10054682 chr5:138259443 C/T cg04439458 chr5:138467593 SIL1 -0.35 -8.61 -0.32 5.84e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10503871 0.905 rs6993952 chr8:30440564 T/C cg26383811 chr8:30366931 RBPMS 0.33 8.91 0.33 5.21e-18 Metabolite levels (X-11787); BRCA cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg01579765 chr21:45077557 HSF2BP -0.4 -10.53 -0.38 4.9299999999999996e-24 Mean corpuscular volume; BRCA cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg08000102 chr2:233561755 GIGYF2 -0.61 -13.56 -0.47 5.62e-37 Coronary artery disease; BRCA cis rs9420 0.961 rs11607056 chr11:57496820 C/T cg19752551 chr11:57585705 CTNND1 -0.51 -12.43 -0.44 6.59e-32 Schizophrenia; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg18402987 chr7:1209562 NA 0.88 14.46 0.5 3.45e-41 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg06552810 chr11:31128660 NA -0.39 -8.73 -0.33 2.2e-17 Red blood cell count; BRCA cis rs9486719 1.000 rs2472897 chr6:96870569 G/T cg06623918 chr6:96969491 KIAA0776 0.73 13.06 0.46 9.81e-35 Migraine;Coronary artery disease; BRCA trans rs35110281 0.782 rs1584917 chr21:45042365 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.29 0.34 2.37e-19 Mean corpuscular volume; BRCA cis rs6121246 0.697 rs6088864 chr20:30228157 G/A cg21427119 chr20:30132790 HM13 -0.43 -9.01 -0.34 2.42e-18 Mean corpuscular hemoglobin; BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg27170947 chr2:26402098 FAM59B -0.7 -11.79 -0.42 3.45e-29 Gut microbiome composition (summer); BRCA cis rs738322 0.967 rs133021 chr22:38573338 T/C cg25457927 chr22:38595422 NA -0.36 -13.23 -0.46 1.68e-35 Cutaneous nevi; BRCA trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg03929089 chr4:120376271 NA 0.48 8.1 0.31 2.74e-15 Axial length; BRCA cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs7072216 0.763 rs6584198 chr10:100169906 G/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs4930561 0.739 rs7118045 chr11:67978734 C/G cg04465784 chr11:67976953 SUV420H1 -0.26 -8.25 -0.31 8.8e-16 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg00106254 chr7:1943704 MAD1L1 0.37 10.32 0.38 3.25e-23 Bipolar disorder and schizophrenia; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs2282802 0.685 rs11748023 chr5:139558584 C/T cg26211634 chr5:139558579 C5orf32 -0.34 -8.11 -0.31 2.56e-15 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg02574844 chr11:5959923 NA -0.4 -8.28 -0.31 7.31e-16 DNA methylation (variation); BRCA cis rs72781680 1.000 rs72781667 chr2:24225667 A/G cg20701182 chr2:24300061 SF3B14 0.57 8.67 0.32 3.66e-17 Lymphocyte counts; BRCA cis rs6964587 1.000 rs57816416 chr7:91736078 A/C cg17063962 chr7:91808500 NA 0.54 12.69 0.45 4.49e-33 Breast cancer; BRCA cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg25817165 chr18:72167213 CNDP2 -0.75 -14.54 -0.5 1.43e-41 Refractive error; BRCA cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA cis rs7264396 0.635 rs6060703 chr20:34529906 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.86 0.3 1.62e-14 Total cholesterol levels; BRCA cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg01579765 chr21:45077557 HSF2BP 0.4 9.47 0.35 5.52e-20 Mean corpuscular volume; BRCA cis rs312274 0.515 rs7300719 chr12:41239198 A/T cg17827154 chr12:41323612 CNTN1 0.36 8.89 0.33 5.99e-18 Metabolite levels (X-11787); BRCA cis rs9834373 0.553 rs9818134 chr3:78495979 A/C cg06138941 chr3:78371609 NA 0.36 8.67 0.32 3.51e-17 Protein quantitative trait loci; BRCA trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg15934090 chr1:100435551 SLC35A3 0.36 8.39 0.32 3.06e-16 Prostate cancer (SNP x SNP interaction); BRCA trans rs11764590 0.715 rs62444907 chr7:2083267 C/T cg25206134 chr2:45395956 NA 0.49 7.86 0.3 1.69e-14 Neuroticism; BRCA cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg05868516 chr6:26286170 HIST1H4H 0.49 11.03 0.4 4.95e-26 Educational attainment; BRCA cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg13334819 chr7:99746414 C7orf59 -0.45 -10.5 -0.38 6.77e-24 Coronary artery disease; BRCA cis rs2251381 0.750 rs2251087 chr21:30527999 C/T cg24692254 chr21:30365293 RNF160 0.64 14.3 0.49 1.98e-40 Selective IgA deficiency; BRCA cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg00531865 chr16:30841666 NA -0.38 -9.07 -0.34 1.49e-18 Dementia with Lewy bodies; BRCA cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 12.29 0.44 2.59e-31 Hip circumference adjusted for BMI; BRCA cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg06636001 chr8:8085503 FLJ10661 0.63 12.12 0.43 1.48e-30 Red cell distribution width; BRCA cis rs68170813 0.559 rs12536603 chr7:107002573 T/C cg02696742 chr7:106810147 HBP1 -0.55 -8.81 -0.33 1.16e-17 Coronary artery disease; BRCA cis rs7647973 1.000 rs11719762 chr3:49409002 G/C cg07636037 chr3:49044803 WDR6 0.75 16.43 0.54 7.51e-51 Menarche (age at onset); BRCA cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.65 0.36 1.2e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11583043 0.831 rs6667818 chr1:101412313 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.51 0.35 3.94e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs61931739 0.500 rs6488209 chr12:34319309 A/G cg06521331 chr12:34319734 NA -0.65 -14.13 -0.49 1.21e-39 Morning vs. evening chronotype; BRCA cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg21770322 chr7:97807741 LMTK2 -0.46 -11.93 -0.43 9.57e-30 Breast cancer; BRCA cis rs1448094 0.511 rs17345975 chr12:86202318 T/A cg19622623 chr12:86230825 RASSF9 -0.31 -8.38 -0.31 3.35e-16 Major depressive disorder; BRCA cis rs7772486 0.754 rs4360151 chr6:146255079 A/C cg23711669 chr6:146136114 FBXO30 -0.68 -15.88 -0.53 4.29e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs1904096 0.506 rs4693381 chr4:95206855 A/T cg11021082 chr4:95130006 SMARCAD1 0.45 10.46 0.38 9.26e-24 Type 2 diabetes; BRCA trans rs35847492 1.000 rs35847492 chr8:9276025 G/C cg15556689 chr8:8085844 FLJ10661 0.34 8.11 0.31 2.62e-15 Neuroticism; BRCA cis rs208520 0.526 rs6455072 chr6:66797215 A/G cg07460842 chr6:66804631 NA -1.16 -37.83 -0.83 2.9e-165 Exhaled nitric oxide output; BRCA trans rs12517041 1.000 rs1428629 chr5:23311989 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.27 -0.31 7.52e-16 Calcium levels; BRCA cis rs7264396 0.887 rs224344 chr20:34036865 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.3 -0.31 6.1e-16 Total cholesterol levels; BRCA cis rs9325144 0.723 rs11169482 chr12:39164327 A/T cg26384229 chr12:38710491 ALG10B 0.52 11.42 0.41 1.25e-27 Morning vs. evening chronotype; BRCA cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg19628046 chr18:33552617 C18orf21 0.56 11.59 0.42 2.47e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs367943 0.712 rs7731465 chr5:112687385 A/G cg12552261 chr5:112820674 MCC -0.39 -8.55 -0.32 8.73e-17 Type 2 diabetes; BRCA cis rs17601876 0.814 rs28637352 chr15:51559666 C/A cg19946085 chr15:51559439 CYP19A1 -0.39 -11.66 -0.42 1.27e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs117623576 0.941 rs211423 chr10:32398777 A/G cg03047570 chr10:32398778 NA 0.64 9.55 0.35 2.67e-20 Anti-saccade response; BRCA cis rs7666738 0.830 rs2865990 chr4:99067399 C/A cg05340658 chr4:99064831 C4orf37 0.7 17.48 0.57 3.14e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs3925075 1.000 rs9673404 chr16:31347592 A/T cg02846316 chr16:31340340 ITGAM 0.53 13.04 0.46 1.2e-34 IgA nephropathy; BRCA cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.63 0.36 1.36e-20 Lung cancer in ever smokers; BRCA cis rs61931739 0.517 rs9668303 chr12:34366701 C/T cg06521331 chr12:34319734 NA -0.55 -9.88 -0.36 1.55e-21 Morning vs. evening chronotype; BRCA trans rs9467711 0.606 rs34781270 chr6:26593037 A/G cg01620082 chr3:125678407 NA -0.71 -8.8 -0.33 1.28e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs11229555 0.874 rs10896794 chr11:58339124 T/C cg15696309 chr11:58395628 NA -0.54 -11.83 -0.42 2.46e-29 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2066819 1.000 rs58852079 chr12:56706922 A/C cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.68 0.36 9.18e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.546 rs11097591 chr4:98910173 G/A cg05340658 chr4:99064831 C4orf37 0.57 11.15 0.4 1.7e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs6910061 1.000 rs2327335 chr6:11119047 A/G cg27233058 chr6:11094804 LOC221710 -0.54 -9.73 -0.36 5.64e-21 Diabetic kidney disease; BRCA cis rs7193541 0.640 rs4072222 chr16:74706736 A/C cg01733217 chr16:74700730 RFWD3 0.87 30.35 0.77 5.56e-126 Multiple myeloma; BRCA cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg03526776 chr6:41159608 TREML2 -0.41 -8.27 -0.31 7.67e-16 Alzheimer's disease (late onset); BRCA cis rs977987 0.778 rs2113232 chr16:75391185 T/C cg03315344 chr16:75512273 CHST6 0.53 12.66 0.45 5.93e-33 Dupuytren's disease; BRCA cis rs17741873 0.779 rs12572101 chr10:75600651 A/G cg07699608 chr10:75541558 CHCHD1 0.48 7.81 0.3 2.38e-14 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg05025164 chr4:1340916 KIAA1530 0.66 13.38 0.47 3.53e-36 Longevity; BRCA trans rs629535 0.862 rs655028 chr8:70049047 T/C cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg06064525 chr11:970664 AP2A2 -0.33 -9.82 -0.36 2.81e-21 Alzheimer's disease (late onset); BRCA trans rs6479891 1.000 rs12414159 chr10:65238777 A/T cg14819942 chr15:35414228 NA 0.35 8.51 0.32 1.23e-16 Arthritis (juvenile idiopathic); BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg22903471 chr2:27725779 GCKR 0.38 9.3 0.35 2.29e-19 Total body bone mineral density; BRCA cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg24642439 chr20:33292090 TP53INP2 -0.53 -11.39 -0.41 1.67e-27 Glomerular filtration rate (creatinine); BRCA trans rs3733585 0.648 rs13103497 chr4:9979262 A/G cg26043149 chr18:55253948 FECH 0.36 7.91 0.3 1.12e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg15112475 chr7:1198522 ZFAND2A -0.43 -8.36 -0.31 3.79e-16 Bronchopulmonary dysplasia; BRCA cis rs17253792 0.822 rs77676035 chr14:56096229 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs586533 0.813 rs636504 chr11:99495693 G/A cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs78456975 0.739 rs11896906 chr2:1519550 A/G cg01028140 chr2:1542097 TPO -0.69 -13.79 -0.48 4.63e-38 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.52 7.99 0.3 6.55e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg27490568 chr2:178487706 NA -0.47 -8.21 -0.31 1.25e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11098499 0.662 rs13108589 chr4:120268102 G/C cg09307838 chr4:120376055 NA 0.63 13.36 0.47 4.56e-36 Corneal astigmatism; BRCA cis rs2404602 0.684 rs11854850 chr15:76844571 C/T cg23625390 chr15:77176239 SCAPER -0.55 -13.68 -0.48 1.56e-37 Blood metabolite levels; BRCA cis rs3849570 1.000 rs78242412 chr3:81747219 A/G cg07356753 chr3:81810745 GBE1 -0.46 -11.15 -0.4 1.71e-26 Waist circumference;Body mass index; BRCA trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg13010199 chr12:38710504 ALG10B -0.43 -8.74 -0.33 2.01e-17 Morning vs. evening chronotype; BRCA cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg13319975 chr6:146136371 FBXO30 -0.37 -8.54 -0.32 9.45e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg11843238 chr5:131593191 PDLIM4 0.37 9.67 0.36 9.4499999999999992e-21 Breast cancer; BRCA cis rs921968 0.540 rs7582329 chr2:219620909 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 3.87e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg04546413 chr19:29218101 NA 0.65 12.46 0.44 4.94e-32 Methadone dose in opioid dependence; BRCA cis rs34779708 0.966 rs878264 chr10:35440581 T/C cg03585969 chr10:35415529 CREM 0.49 10.38 0.38 1.94e-23 Inflammatory bowel disease;Crohn's disease; BRCA trans rs1493916 0.905 rs34165207 chr18:31400153 G/A cg15819921 chr19:927150 ARID3A -0.45 -8.54 -0.32 9.84e-17 Life satisfaction; BRCA cis rs2806561 0.765 rs1738470 chr1:23511911 G/A cg12483005 chr1:23474871 LUZP1 0.45 9.97 0.37 7.71e-22 Height; BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg21724239 chr8:58056113 NA 0.62 9.69 0.36 8.16e-21 Developmental language disorder (linguistic errors); BRCA cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.81 -0.33 1.22e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9296092 0.538 rs9469488 chr6:33517117 G/T cg13560919 chr6:33536144 NA -0.85 -17.45 -0.57 4.51e-56 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg22907277 chr7:1156413 C7orf50 0.46 10.79 0.39 4.62e-25 Longevity;Endometriosis; BRCA cis rs5997397 1.000 rs5997397 chr22:29154455 A/G cg15103426 chr22:29168792 CCDC117 0.45 10.8 0.39 4.41e-25 Red cell distribution width; BRCA cis rs6750047 0.566 rs1157184 chr2:38285774 C/G cg07380506 chr2:38303506 CYP1B1 0.49 11.63 0.42 1.72e-28 Cutaneous malignant melanoma;Melanoma; BRCA trans rs1325195 0.920 rs4651013 chr1:179072966 C/T cg11624085 chr17:8464688 MYH10 -0.26 -8.15 -0.31 1.93e-15 IgE grass sensitization; BRCA trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg03929089 chr4:120376271 NA -0.9 -24.17 -0.69 3.67e-92 Height; BRCA cis rs1577917 0.655 rs1059307 chr6:86387888 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.37 10.13 0.37 1.85e-22 Response to antipsychotic treatment; BRCA cis rs34779708 0.931 rs11597392 chr10:35288575 T/C cg03585969 chr10:35415529 CREM 0.55 11.28 0.41 4.72e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs644799 0.623 rs17207890 chr11:95490754 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.64 13.87 0.48 2.07e-38 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg15017067 chr4:17643749 FAM184B 0.29 8.74 0.33 1.99e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4478858 0.735 rs6679365 chr1:31787866 A/C cg00250761 chr1:31883323 NA 0.31 8.11 0.31 2.56e-15 Alcohol dependence; BRCA cis rs7523273 0.606 rs2796283 chr1:207978732 C/T cg22525895 chr1:207977042 MIR29B2 -0.48 -12.49 -0.44 3.59e-32 Schizophrenia; BRCA cis rs208520 0.837 rs208486 chr6:66926255 A/T cg07460842 chr6:66804631 NA -0.89 -15.7 -0.53 3.28e-47 Exhaled nitric oxide output; BRCA cis rs17253792 0.822 rs10147431 chr14:56091841 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg20307385 chr11:47447363 PSMC3 -0.41 -8.24 -0.31 9.74e-16 Subjective well-being; BRCA cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg12923728 chr3:195709715 SDHAP1 -0.58 -12.45 -0.44 5.43e-32 Pancreatic cancer; BRCA cis rs9467773 0.620 rs2130657 chr6:26650826 C/T cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.02e-42 Intelligence (multi-trait analysis); BRCA cis rs11229555 1.000 rs12787765 chr11:58400686 G/A cg15696309 chr11:58395628 NA -0.52 -11.48 -0.41 6.93e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.54 0.77 5.46e-127 Chronic sinus infection; BRCA cis rs7267979 1.000 rs2258066 chr20:25271326 C/T cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg13047869 chr3:10149882 C3orf24 0.59 12.27 0.44 3.13e-31 Alzheimer's disease; BRCA cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs752010 0.619 rs7539238 chr1:42113572 A/C cg06885757 chr1:42089581 HIVEP3 0.29 9.95 0.37 9.07e-22 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.83 -0.33 1.03e-17 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs77633900 0.614 rs280008 chr15:77011815 T/C cg21673338 chr15:77095150 SCAPER -0.53 -9.77 -0.36 4.33e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.96 15.04 0.51 5.21e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.67 0.39 1.39e-24 Tonsillectomy; BRCA cis rs2243480 1.000 rs160633 chr7:65528228 T/C cg18252515 chr7:66147081 NA -1.05 -14.44 -0.5 4.29e-41 Diabetic kidney disease; BRCA cis rs6740322 0.841 rs10211126 chr2:43551416 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -11.77 -0.42 4.52e-29 Coronary artery disease; BRCA cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg20607287 chr7:12443886 VWDE -0.58 -8.32 -0.31 5.31e-16 Coronary artery disease; BRCA cis rs72772090 0.539 rs72773922 chr5:96116660 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.19 -0.43 7.23e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs3780486 0.846 rs7850878 chr9:33126570 A/G cg20290983 chr6:43655470 MRPS18A 1.11 40.93 0.85 1.03e-180 IgG glycosylation; BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg07262247 chr5:131593730 PDLIM4 0.34 7.82 0.3 2.19e-14 Acylcarnitine levels; BRCA cis rs2243480 1.000 rs313798 chr7:65493031 A/G cg18252515 chr7:66147081 NA -0.91 -12.95 -0.46 3.02e-34 Diabetic kidney disease; BRCA cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg05347473 chr6:146136440 FBXO30 0.39 8.1 0.31 2.73e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg22907277 chr7:1156413 C7orf50 0.52 11.41 0.41 1.44e-27 Longevity;Endometriosis; BRCA cis rs7927592 0.912 rs55767696 chr11:68375120 C/G cg20283391 chr11:68216788 NA -0.43 -9.1 -0.34 1.14e-18 Total body bone mineral density; BRCA cis rs9420 0.884 rs589914 chr11:57661032 A/G cg19752551 chr11:57585705 CTNND1 0.5 12.07 0.43 2.32e-30 Schizophrenia; BRCA cis rs7727544 0.606 rs2631360 chr5:131707429 A/G cg14196790 chr5:131705035 SLC22A5 0.5 13.99 0.48 5.41e-39 Blood metabolite levels; BRCA cis rs2882667 0.505 rs7721110 chr5:138482506 G/T cg04439458 chr5:138467593 SIL1 -0.31 -8.34 -0.31 4.57e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs77633900 0.614 rs2585730 chr15:76989344 A/G cg21673338 chr15:77095150 SCAPER -0.53 -9.54 -0.35 3.05e-20 Non-glioblastoma glioma;Glioma; BRCA cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg13319975 chr6:146136371 FBXO30 -0.36 -8.34 -0.31 4.54e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.667 rs914197 chr21:45117439 A/G cg01579765 chr21:45077557 HSF2BP -0.44 -11.72 -0.42 6.85e-29 Mean corpuscular volume; BRCA cis rs1538970 0.884 rs61788261 chr1:45899114 G/A cg05343316 chr1:45956843 TESK2 0.62 12.46 0.44 4.58e-32 Platelet count; BRCA trans rs11295209 1 rs11295209 chr4:120480233 TA/T cg25214090 chr10:38739885 LOC399744 -0.34 -7.96 -0.3 7.6e-15 Plateletcrit; BRCA cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg24920358 chr1:40204285 PPIE 0.35 8.02 0.3 5.03e-15 Blood protein levels; BRCA trans rs208520 0.690 rs10455194 chr6:66743356 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.89 0.64 3.01e-74 Exhaled nitric oxide output; BRCA cis rs911119 1.000 rs911119 chr20:23612737 C/T cg16589663 chr20:23618590 CST3 -0.41 -7.92 -0.3 1.08e-14 Chronic kidney disease; BRCA cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg21782813 chr7:2030301 MAD1L1 0.4 11.33 0.41 3.03e-27 Bipolar disorder and schizophrenia; BRCA cis rs2439831 0.557 rs13329084 chr15:44151063 A/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.91 -13.26 -0.46 1.3e-35 Lung cancer in ever smokers; BRCA cis rs6835098 0.961 rs2078475 chr4:174098226 A/C cg27433088 chr4:174089019 GALNT7 -0.33 -8.5 -0.32 1.3e-16 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs79976124 0.837 rs11751994 chr6:66644028 A/C cg07460842 chr6:66804631 NA 0.6 10.31 0.38 3.59e-23 Type 2 diabetes; BRCA cis rs3824867 0.920 rs7101772 chr11:47449378 A/G cg20307385 chr11:47447363 PSMC3 -0.49 -10.98 -0.4 8.18e-26 Mean corpuscular hemoglobin; BRCA cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg26384229 chr12:38710491 ALG10B 0.66 15.4 0.52 9.23e-46 Bladder cancer; BRCA cis rs7684253 0.565 rs6830774 chr4:57816306 T/C cg11939399 chr4:57773300 REST 0.29 7.97 0.3 7.32e-15 Migraine; BRCA cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg10729496 chr3:10149963 C3orf24 0.42 8.08 0.3 3.25e-15 Alzheimer's disease; BRCA cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg01939980 chr4:1354348 KIAA1530 0.3 8.06 0.3 3.67e-15 Longevity; BRCA cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg27121462 chr16:89883253 FANCA -0.51 -11.44 -0.41 1.02e-27 Vitiligo; BRCA cis rs208520 0.690 rs4710564 chr6:66823478 A/G cg07460842 chr6:66804631 NA 0.89 17.13 0.56 1.98e-54 Exhaled nitric oxide output; BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -8.77 -0.33 1.64e-17 Bipolar disorder and schizophrenia; BRCA cis rs9486715 0.867 rs7451950 chr6:96879974 T/C cg06623918 chr6:96969491 KIAA0776 0.9 25.54 0.71 1.14e-99 Headache; BRCA cis rs8038465 0.516 rs8037836 chr15:73859855 G/A cg15420318 chr15:73925796 NPTN 0.49 11.3 0.41 4.1e-27 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg20701182 chr2:24300061 SF3B14 0.7 13.37 0.47 4.01e-36 Lymphocyte counts; BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg04944784 chr2:26401820 FAM59B -0.66 -10.76 -0.39 6.37e-25 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg05340658 chr4:99064831 C4orf37 0.62 14.72 0.5 1.94e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs8009147 1 rs8009147 chr14:104264662 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.58 0.59 5.9e-62 Autism spectrum disorder or schizophrenia; BRCA cis rs6539267 0.847 rs17217845 chr12:106697802 C/T cg02476566 chr12:106696527 TCP11L2 -0.52 -8.31 -0.31 5.94e-16 Tourette syndrome; BRCA cis rs7267979 0.816 rs3746337 chr20:25208272 C/T cg08601574 chr20:25228251 PYGB 0.37 8.62 0.32 5.22e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg19748678 chr4:122722346 EXOSC9 0.67 13.91 0.48 1.24e-38 Type 2 diabetes; BRCA cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg02475777 chr4:1388615 CRIPAK -0.63 -12.5 -0.44 3.23e-32 Longevity; BRCA cis rs11190604 0.666 rs7084768 chr10:102200497 T/C cg07080220 chr10:102295463 HIF1AN -0.44 -10.06 -0.37 3.37e-22 Palmitoleic acid (16:1n-7) levels; BRCA trans rs3857536 0.611 rs7748258 chr6:66932840 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.11 -0.31 2.53e-15 Blood trace element (Cu levels); BRCA cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg25319279 chr11:5960081 NA -0.42 -8.15 -0.31 1.95e-15 DNA methylation (variation); BRCA cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.66 0.57 3.84e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg00684032 chr4:1343700 KIAA1530 0.51 12.31 0.44 2.21e-31 Obesity-related traits; BRCA cis rs4891159 0.513 rs35534021 chr18:74130523 G/A cg24786174 chr18:74118243 ZNF516 0.82 24.48 0.7 6.91e-94 Longevity; BRCA trans rs1493916 0.905 rs1586988 chr18:31396001 G/C cg27147174 chr7:100797783 AP1S1 -0.56 -10.9 -0.4 1.69e-25 Life satisfaction; BRCA cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg25358565 chr5:93447407 FAM172A 1.18 19.6 0.61 2.41e-67 Diabetic retinopathy; BRCA cis rs6121246 0.865 rs77130187 chr20:30269060 G/A cg13852791 chr20:30311386 BCL2L1 0.8 11.54 0.42 3.92e-28 Mean corpuscular hemoglobin; BRCA cis rs1555322 0.505 rs639763 chr20:33861904 C/T cg03689076 chr20:33865952 NA 0.47 8.29 0.31 6.86e-16 Attention deficit hyperactivity disorder; BRCA cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.62 11.63 0.42 1.75e-28 Gut microbiome composition (summer); BRCA cis rs9393777 0.582 rs6936561 chr6:26640895 C/T cg12826209 chr6:26865740 GUSBL1 0.59 10.29 0.38 4.46e-23 Intelligence (multi-trait analysis); BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18301423 chr5:131593218 PDLIM4 0.33 8.48 0.32 1.53e-16 Breast cancer; BRCA cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24308560 chr3:49941425 MST1R -0.4 -8.57 -0.32 7.64e-17 Intelligence (multi-trait analysis); BRCA cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg08999081 chr20:33150536 PIGU 0.34 8.66 0.32 3.7e-17 Coronary artery disease; BRCA cis rs2882667 1.000 rs10064130 chr5:138309307 C/T cg04439458 chr5:138467593 SIL1 -0.38 -9.86 -0.36 1.84e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg05340658 chr4:99064831 C4orf37 0.67 16.52 0.55 2.45e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg05872129 chr22:39784769 NA 0.55 11.7 0.42 8.5e-29 Intelligence (multi-trait analysis); BRCA cis rs7553864 0.614 rs4559475 chr1:87614236 T/C cg17420885 chr1:87600446 LOC339524 -0.41 -8.0 -0.3 6.02e-15 Smoking behavior; BRCA cis rs72387598 1 rs72387598 chr1:45922977 CAT/C cg05343316 chr1:45956843 TESK2 0.66 13.3 0.47 7.95e-36 Platelet distribution width; BRCA cis rs1538970 0.924 rs1826691 chr1:45881262 A/G cg05343316 chr1:45956843 TESK2 -0.6 -11.79 -0.42 3.51e-29 Platelet count; BRCA cis rs17376456 0.877 rs10078194 chr5:93364310 A/C cg21475434 chr5:93447410 FAM172A 0.66 8.91 0.33 5.22e-18 Diabetic retinopathy; BRCA cis rs6570726 0.967 rs450973 chr6:145863065 C/A cg23711669 chr6:146136114 FBXO30 0.63 14.22 0.49 4.66e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 1.000 rs4808962 chr19:19579557 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg14440974 chr22:39074834 NA -0.39 -9.16 -0.34 6.75e-19 Menopause (age at onset); BRCA cis rs4642101 0.824 rs9852222 chr3:12848491 G/T cg24848339 chr3:12840334 CAND2 0.41 10.56 0.39 4.02e-24 QRS complex (12-leadsum); BRCA cis rs6840360 0.615 rs9884167 chr4:152470799 A/G cg22705602 chr4:152727874 NA -0.32 -8.32 -0.31 5.2e-16 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg22800045 chr5:56110881 MAP3K1 0.61 11.45 0.41 9.32e-28 Initial pursuit acceleration; BRCA cis rs9311474 0.713 rs352168 chr3:52237970 C/T cg15698299 chr3:52233019 ALAS1 -0.38 -8.95 -0.33 3.9e-18 Electroencephalogram traits; BRCA cis rs17767294 0.708 rs9380018 chr6:27740646 A/G cg08851530 chr6:28072375 NA 0.74 7.89 0.3 1.29e-14 Parkinson's disease; BRCA cis rs4268898 0.965 rs13033241 chr2:24476118 G/C cg06627628 chr2:24431161 ITSN2 0.49 10.23 0.38 7.72e-23 Asthma; BRCA cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg13010199 chr12:38710504 ALG10B 0.52 10.96 0.4 9.82e-26 Drug-induced liver injury (flucloxacillin); BRCA cis rs2658782 0.547 rs3020052 chr11:93055184 C/G cg15737290 chr11:93063684 CCDC67 0.58 13.96 0.48 7.76e-39 Pulmonary function decline; BRCA cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg08514558 chr10:81106712 PPIF -0.39 -9.04 -0.34 1.84e-18 Height; BRCA cis rs3820928 0.874 rs7582251 chr2:227791703 G/T cg11843606 chr2:227700838 RHBDD1 -0.39 -8.72 -0.33 2.46e-17 Pulmonary function; BRCA cis rs6570726 0.967 rs418662 chr6:145848832 A/C cg23711669 chr6:146136114 FBXO30 0.65 14.69 0.5 2.59e-42 Lobe attachment (rater-scored or self-reported); BRCA trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.15 -17.53 -0.57 1.79e-56 Hemostatic factors and hematological phenotypes; BRCA cis rs2404602 0.647 rs11072620 chr15:77048770 T/A cg23625390 chr15:77176239 SCAPER -0.55 -13.89 -0.48 1.61e-38 Blood metabolite levels; BRCA cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg10978503 chr1:24200527 CNR2 -0.43 -9.41 -0.35 8.82e-20 Immature fraction of reticulocytes; BRCA cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.46e-23 Motion sickness; BRCA cis rs17270561 0.583 rs6926425 chr6:25785304 T/C cg16482183 chr6:26056742 HIST1H1C 0.44 9.15 0.34 7.27e-19 Iron status biomarkers; BRCA cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.91 0.37 1.21e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3820928 0.874 rs10174073 chr2:227794944 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -8.78 -0.33 1.46e-17 Pulmonary function; BRCA cis rs586533 0.881 rs624620 chr11:99505353 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9811920 0.809 rs6440967 chr3:99722396 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.57 13.83 0.48 2.97e-38 Axial length; BRCA cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg22467129 chr15:76604101 ETFA -0.4 -8.99 -0.34 2.75e-18 Blood metabolite levels; BRCA cis rs6545883 0.895 rs2442029 chr2:61679552 G/T cg15711740 chr2:61764176 XPO1 -0.53 -12.64 -0.45 7.37e-33 Tuberculosis; BRCA cis rs7246657 0.941 rs12982333 chr19:37794724 A/G cg23950597 chr19:37808831 NA -0.63 -10.93 -0.4 1.3e-25 Coronary artery calcification; BRCA cis rs17381785 0.531 rs34479500 chr4:14939389 G/A cg12377275 chr4:15005593 CPEB2 0.46 8.15 0.31 1.87e-15 Urate levels in overweight individuals; BRCA cis rs6430585 0.941 rs6708957 chr2:136520043 C/T cg07169764 chr2:136633963 MCM6 1.0 20.31 0.63 4.04e-71 Corneal structure; BRCA cis rs7493 0.760 rs17876092 chr7:95053313 C/A cg19678392 chr7:94953810 PON1 -0.42 -8.58 -0.32 7.05e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10189230 0.967 rs13002861 chr2:222352859 T/G cg14652038 chr2:222343519 EPHA4 0.46 12.75 0.45 2.51e-33 Urate levels in lean individuals; BRCA cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg04511125 chr2:88470314 THNSL2 0.8 11.59 0.42 2.46e-28 Plasma clusterin levels; BRCA cis rs116095464 0.558 rs7356535 chr5:284117 G/T cg22857025 chr5:266934 NA -1.04 -19.68 -0.61 9.4e-68 Breast cancer; BRCA cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg02951883 chr7:2050386 MAD1L1 -0.55 -12.34 -0.44 1.63e-31 Schizophrenia; BRCA cis rs2235642 0.928 rs1057610 chr16:1605537 T/C cg26528668 chr16:1614120 IFT140 0.37 8.33 0.31 4.87e-16 Coronary artery disease; BRCA cis rs2777491 0.789 rs316617 chr15:41795900 C/T cg18705301 chr15:41695430 NDUFAF1 0.49 10.72 0.39 8.97e-25 Ulcerative colitis; BRCA cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg12935359 chr14:103987150 CKB -0.6 -14.09 -0.49 1.78e-39 Body mass index; BRCA cis rs57221529 0.766 rs4245972 chr5:578572 A/G cg09021430 chr5:549028 NA -0.68 -14.24 -0.49 3.68e-40 Lung disease severity in cystic fibrosis; BRCA cis rs7640424 0.819 rs162070 chr3:107835448 G/A cg09227934 chr3:107805635 CD47 0.41 8.63 0.32 4.76e-17 Body mass index; BRCA cis rs1799922 0.693 rs339086 chr7:128423617 T/C cg02354431 chr7:128423266 NA 0.36 9.22 0.34 4.19e-19 Primary tooth development (number of teeth);Primary tooth development (time to first tooth eruption); BRCA cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg13319975 chr6:146136371 FBXO30 0.44 10.03 0.37 4.55e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg20701182 chr2:24300061 SF3B14 0.68 12.9 0.45 5.2e-34 Lymphocyte counts; BRCA cis rs7617773 0.780 rs79089926 chr3:48348564 A/C cg11946769 chr3:48343235 NME6 0.68 13.86 0.48 2.24e-38 Coronary artery disease; BRCA cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg16743903 chr16:89593216 SPG7 0.31 8.16 0.31 1.73e-15 Multiple myeloma (IgH translocation); BRCA cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg16339924 chr4:17578868 LAP3 0.76 17.93 0.58 1.6e-58 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs57677839 1 rs57677839 chr11:17028189 G/A cg01977079 chr11:17036644 PLEKHA7 -0.33 -8.55 -0.32 9.34e-17 Coronary artery disease; BRCA cis rs1829883 0.651 rs2460653 chr5:98825627 A/G cg08333243 chr5:99726346 NA -0.36 -7.81 -0.3 2.41e-14 Hemostatic factors and hematological phenotypes; BRCA cis rs6138458 1.000 rs6114981 chr20:24974401 C/T cg26195577 chr20:24973756 C20orf3 -0.97 -27.09 -0.73 3.13e-108 Blood protein levels; BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.06 0.34 1.61e-18 Platelet count; BRCA cis rs9283706 0.608 rs13189948 chr5:66355306 A/G cg11590213 chr5:66331682 MAST4 0.4 8.03 0.3 4.72e-15 Coronary artery disease; BRCA cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg08045932 chr20:61659980 NA 0.5 11.4 0.41 1.63e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg03354898 chr7:1950403 MAD1L1 -0.39 -8.61 -0.32 5.63e-17 Schizophrenia; BRCA cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.53 0.42 4.43e-28 Homoarginine levels; BRCA cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg05340658 chr4:99064831 C4orf37 -0.68 -16.97 -0.56 1.4e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6684514 0.961 rs10908501 chr1:156285513 G/T cg16558208 chr1:156270281 VHLL 0.36 8.36 0.31 4.06e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.43 8.22 0.31 1.11e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs208520 0.526 rs9294682 chr6:66795159 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.15 -39.11 -0.84 1.1e-171 Exhaled nitric oxide output; BRCA cis rs1788820 0.917 rs1624695 chr18:21142992 A/T cg14672496 chr18:21087552 C18orf8 0.35 8.53 0.32 1.06e-16 Body mass index; BRCA cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg19539972 chr4:7069911 GRPEL1 0.68 17.0 0.56 9.84e-54 Monocyte percentage of white cells; BRCA cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg09555818 chr19:45449301 APOC2 0.45 11.76 0.42 4.78e-29 Blood protein levels; BRCA cis rs3925075 0.903 rs36100148 chr16:31345023 C/T cg02846316 chr16:31340340 ITGAM 0.54 13.33 0.47 5.89e-36 IgA nephropathy; BRCA cis rs12541635 0.677 rs1496183 chr8:107024445 C/T cg10147462 chr8:107024639 NA 0.4 10.98 0.4 7.87e-26 Age of smoking initiation; BRCA cis rs10779751 0.770 rs11121691 chr1:11181327 C/T cg08854313 chr1:11322531 MTOR -0.73 -14.45 -0.5 3.64e-41 Body mass index; BRCA cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg12219531 chr12:120966889 COQ5 0.56 11.7 0.42 8.42e-29 High light scatter reticulocyte count; BRCA trans rs877282 0.891 rs11595385 chr10:800539 A/G cg22713356 chr15:30763199 NA 1.4 28.4 0.75 2.36e-115 Uric acid levels; BRCA cis rs208515 0.525 rs10944870 chr6:66687757 G/C cg07460842 chr6:66804631 NA 0.87 15.6 0.53 1.03e-46 Exhaled nitric oxide levels; BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg05793240 chr7:2802953 GNA12 -0.32 -8.23 -0.31 1.03e-15 Height; BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg03709012 chr19:19516395 GATAD2A 0.81 19.22 0.61 2.61e-65 Tonsillectomy; BRCA cis rs7631605 0.845 rs9311149 chr3:37030175 G/T cg15934958 chr3:37212084 LRRFIP2 0.34 7.9 0.3 1.2e-14 Cerebrospinal P-tau181p levels; BRCA cis rs11112613 0.713 rs10507192 chr12:105948247 A/G cg03607813 chr12:105948248 NA 0.66 13.07 0.46 9.2e-35 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg25036284 chr2:26402008 FAM59B -0.89 -15.63 -0.53 7.3e-47 Gut microbiome composition (summer); BRCA cis rs965469 0.779 rs2236121 chr20:3304320 A/G cg25506879 chr20:3388711 C20orf194 -0.45 -8.77 -0.33 1.61e-17 IFN-related cytopenia; BRCA cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg19678392 chr7:94953810 PON1 0.42 9.09 0.34 1.2e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs3780486 0.801 rs10971424 chr9:33138775 T/C cg20290983 chr6:43655470 MRPS18A 1.11 41.43 0.85 3.52e-183 IgG glycosylation; BRCA cis rs9341808 0.718 rs2874829 chr6:80856097 A/G cg08355045 chr6:80787529 NA 0.37 9.29 0.35 2.32e-19 Sitting height ratio; BRCA cis rs10739663 0.520 rs1566362 chr9:128163132 C/T cg14078157 chr9:128172775 NA 0.46 10.54 0.38 4.54e-24 Resting heart rate; BRCA cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg06618935 chr21:46677482 NA -0.36 -7.96 -0.3 8.16e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs4481887 0.893 rs6681339 chr1:248482761 C/G cg13385794 chr1:248469461 NA 0.28 8.11 0.31 2.62e-15 Common traits (Other); BRCA cis rs2251381 0.750 rs2776250 chr21:30528094 T/G cg24692254 chr21:30365293 RNF160 0.64 14.3 0.49 1.98e-40 Selective IgA deficiency; BRCA cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs7945705 0.870 rs4929922 chr11:8975776 A/G cg12365402 chr11:9010492 NRIP3 -0.42 -9.02 -0.34 2.24e-18 Hemoglobin concentration; BRCA cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg12379764 chr21:47803548 PCNT 0.61 12.32 0.44 1.92e-31 Testicular germ cell tumor; BRCA cis rs3768617 0.510 rs10797843 chr1:183081995 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 18.01 0.58 5.98e-59 Fuchs's corneal dystrophy; BRCA cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA trans rs116095464 0.558 rs7356535 chr5:284117 G/T cg00938859 chr5:1591904 SDHAP3 0.69 9.4 0.35 9.53e-20 Breast cancer; BRCA cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg06766960 chr11:133703094 NA -0.63 -13.77 -0.48 5.89e-38 Childhood ear infection; BRCA cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.01 0.4 6.48e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4908768 0.501 rs12061328 chr1:8531963 C/T cg20416874 chr1:8611966 RERE -0.28 -8.19 -0.31 1.43e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs6430585 0.527 rs12467569 chr2:136413847 T/C cg07169764 chr2:136633963 MCM6 1.0 19.49 0.61 9.16e-67 Corneal structure; BRCA cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg11764359 chr7:65958608 NA -0.64 -13.92 -0.48 1.22e-38 Aortic root size; BRCA cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.04 -0.3 4.25e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs897984 0.542 rs750952 chr16:31093954 C/T cg00531865 chr16:30841666 NA -0.35 -8.36 -0.31 3.89e-16 Dementia with Lewy bodies; BRCA cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg23939001 chr4:940644 TMEM175 0.4 9.98 0.37 6.88e-22 Sjögren's syndrome; BRCA cis rs7809950 1.000 rs2520277 chr7:107130234 C/T cg23024343 chr7:107201750 COG5 -0.41 -9.54 -0.35 2.86e-20 Coronary artery disease; BRCA cis rs13108904 0.875 rs3822017 chr4:1236312 C/T cg05665937 chr4:1216051 CTBP1 0.39 8.3 0.31 6.21e-16 Obesity-related traits; BRCA cis rs9467711 0.591 rs56294283 chr6:25976099 A/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.58 9.13 0.34 9e-19 Autism spectrum disorder or schizophrenia; BRCA trans rs6582630 0.519 rs1607882 chr12:38361657 G/A cg06521331 chr12:34319734 NA -0.47 -8.99 -0.34 2.75e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg26384229 chr12:38710491 ALG10B -0.64 -14.89 -0.51 2.95e-43 Drug-induced liver injury (flucloxacillin); BRCA cis rs4074536 0.574 rs4472757 chr1:116293897 A/G cg21648376 chr1:116311395 CASQ2 -0.48 -8.48 -0.32 1.61e-16 QRS duration; BRCA cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.96 0.43 7.13e-30 Height; BRCA cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg19748678 chr4:122722346 EXOSC9 0.74 16.01 0.54 9.39e-49 Type 2 diabetes; BRCA cis rs501916 0.833 rs59184310 chr15:48050205 A/T cg16110827 chr15:48056943 SEMA6D -0.43 -9.15 -0.34 7.52e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.54e-84 Chronic sinus infection; BRCA cis rs7647973 1.000 rs4241407 chr3:49600319 C/T cg07636037 chr3:49044803 WDR6 0.72 15.86 0.53 5.2e-48 Menarche (age at onset); BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg04944784 chr2:26401820 FAM59B 1.0 16.52 0.55 2.51e-51 Gut microbiome composition (summer); BRCA cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 4e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs3768617 1.000 rs1360704 chr1:183099380 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.47 -10.25 -0.38 6.4e-23 Fuchs's corneal dystrophy; BRCA cis rs4588572 0.643 rs10474555 chr5:77799193 A/G cg11547950 chr5:77652471 NA 0.48 8.54 0.32 9.86e-17 Triglycerides; BRCA cis rs2180341 0.804 rs6902233 chr6:127555963 A/G cg24812749 chr6:127587940 RNF146 0.8 15.48 0.52 4.05e-46 Breast cancer; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg03188948 chr7:1209495 NA 0.92 13.73 0.48 8.92e-38 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7944584 0.655 rs11039183 chr11:47346940 G/A cg03711944 chr11:47377212 SPI1 -0.34 -7.99 -0.3 6.11e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs11098499 0.913 rs67073020 chr4:120152557 C/T cg25214090 chr10:38739885 LOC399744 0.51 10.78 0.39 5.13e-25 Corneal astigmatism; BRCA cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg24562669 chr7:97807699 LMTK2 0.45 12.23 0.44 4.67e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg15997130 chr1:24165203 NA 0.44 11.49 0.41 6.91e-28 Immature fraction of reticulocytes; BRCA cis rs28735056 0.967 rs8091497 chr18:77632565 G/A cg20368463 chr18:77673604 PQLC1 -0.34 -8.0 -0.3 5.95e-15 Schizophrenia; BRCA cis rs11920090 0.858 rs55692900 chr3:170701587 T/G cg09710316 chr3:170744871 SLC2A2 0.5 8.01 0.3 5.52e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg27129171 chr3:47204927 SETD2 -0.67 -15.31 -0.52 2.71e-45 Colorectal cancer; BRCA cis rs17095355 1.000 rs12570612 chr10:111717685 C/T cg00817464 chr10:111662876 XPNPEP1 0.34 9.0 0.34 2.64e-18 Biliary atresia; BRCA cis rs911119 0.955 rs4815224 chr20:23594112 C/G cg16589663 chr20:23618590 CST3 0.45 8.41 0.32 2.61e-16 Chronic kidney disease; BRCA cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.16 0.62 2.63e-70 Chronic sinus infection; BRCA cis rs6088813 0.961 rs1886691 chr20:33986271 T/C cg14752227 chr20:34000481 UQCC -0.42 -8.92 -0.33 4.83e-18 Height; BRCA cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg00898013 chr13:113819073 PROZ -0.36 -8.61 -0.32 5.52e-17 Platelet distribution width; BRCA cis rs7809950 0.678 rs2395868 chr7:106897500 C/T cg23024343 chr7:107201750 COG5 0.42 8.59 0.32 6.8e-17 Coronary artery disease; BRCA cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg10932868 chr11:921992 NA 0.51 13.27 0.46 1.11e-35 Alzheimer's disease (late onset); BRCA cis rs71636778 0.543 rs17162333 chr1:27236757 C/G cg12203394 chr1:27248618 NUDC 0.6 9.46 0.35 5.7e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg24549020 chr5:56110836 MAP3K1 0.66 13.44 0.47 1.98e-36 Initial pursuit acceleration; BRCA cis rs1577917 0.958 rs6454488 chr6:86450842 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.25 -0.44 3.78e-31 Response to antipsychotic treatment; BRCA cis rs250677 0.522 rs919730 chr5:148352401 T/C cg18129178 chr5:148520854 ABLIM3 0.55 10.49 0.38 7.11e-24 Breast cancer; BRCA cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.48 0.5 2.79e-41 Motion sickness; BRCA cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg16339924 chr4:17578868 LAP3 0.64 15.89 0.53 3.68e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10131894 0.611 rs175001 chr14:75436452 A/C cg06637938 chr14:75390232 RPS6KL1 0.4 7.95 0.3 8.45e-15 Coronary artery disease; BRCA cis rs921968 0.542 rs588182 chr2:219412335 C/A cg10223061 chr2:219282414 VIL1 -0.27 -8.16 -0.31 1.76e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg10494973 chr17:80897199 TBCD 0.36 8.15 0.31 1.95e-15 Breast cancer; BRCA cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg25174290 chr11:3078921 CARS 0.43 12.74 0.45 2.85e-33 Longevity; BRCA cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg06784218 chr1:46089804 CCDC17 -0.52 -12.42 -0.44 7.05e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs7246657 0.882 rs8112610 chr19:37928730 C/A cg18154014 chr19:37997991 ZNF793 0.47 9.36 0.35 1.33e-19 Coronary artery calcification; BRCA cis rs1448094 0.512 rs7970842 chr12:86243258 C/T cg19622623 chr12:86230825 RASSF9 -0.34 -9.58 -0.35 2.05e-20 Major depressive disorder; BRCA cis rs3806843 1.000 rs7710794 chr5:140209467 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.87 -0.36 1.77e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs514406 0.679 rs545719 chr1:53304922 T/C cg25767906 chr1:53392781 SCP2 -0.47 -10.2 -0.37 9.75e-23 Monocyte count; BRCA cis rs921968 0.648 rs538483 chr2:219458656 T/C cg02176678 chr2:219576539 TTLL4 0.4 10.96 0.4 9.73e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg01028140 chr2:1542097 TPO -0.62 -11.76 -0.42 4.75e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6120849 0.707 rs6088694 chr20:33652371 G/A cg24642439 chr20:33292090 TP53INP2 0.59 10.18 0.37 1.16e-22 Protein C levels; BRCA cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg08917208 chr2:24149416 ATAD2B 1.12 15.98 0.53 1.31e-48 Lymphocyte counts; BRCA cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.49 -0.32 1.48e-16 Monocyte percentage of white cells; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg24101359 chr6:42928495 GNMT 0.55 12.58 0.45 1.45e-32 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7903847 0.642 rs11189182 chr10:99144186 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg27541892 chr1:1571801 CDK11B -0.35 -7.82 -0.3 2.12e-14 Body mass index; BRCA cis rs6545883 0.507 rs4411680 chr2:61584105 A/C cg15711740 chr2:61764176 XPO1 0.32 7.82 0.3 2.24e-14 Tuberculosis; BRCA cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14442939 chr10:27389572 ANKRD26 0.69 11.4 0.41 1.61e-27 Breast cancer; BRCA cis rs2425143 0.818 rs73902932 chr20:34489009 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.25 -0.31 8.87e-16 Blood protein levels; BRCA cis rs9325144 0.505 rs1906262 chr12:38653605 A/G cg13010199 chr12:38710504 ALG10B 0.4 9.07 0.34 1.47e-18 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg20607798 chr8:58055168 NA 0.49 8.52 0.32 1.19e-16 Developmental language disorder (linguistic errors); BRCA cis rs765787 0.530 rs28815867 chr15:45526805 G/C cg15395560 chr15:45543142 SLC28A2 0.29 8.3 0.31 6.43e-16 Uric acid levels; BRCA cis rs7524258 0.835 rs75096060 chr1:7270248 G/C cg07173049 chr1:7289937 CAMTA1 0.45 11.12 0.4 2.16e-26 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs34779708 0.966 rs12775548 chr10:35479504 G/T cg03585969 chr10:35415529 CREM 0.54 11.18 0.4 1.28e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12477438 0.798 rs1530996 chr2:99584079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.83 -0.51 5.41e-43 Chronic sinus infection; BRCA cis rs7666738 0.830 rs7689495 chr4:98920152 T/C cg05340658 chr4:99064831 C4orf37 0.65 16.1 0.54 3.24e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs2625529 0.668 rs34487006 chr15:72462350 G/T cg16672083 chr15:72433130 SENP8 -0.84 -17.82 -0.58 5.65e-58 Red blood cell count; BRCA cis rs7737355 0.947 rs4996522 chr5:130761470 G/A cg06307176 chr5:131281290 NA -0.51 -9.8 -0.36 3.09e-21 Life satisfaction; BRCA cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg04586622 chr2:25135609 ADCY3 0.44 11.05 0.4 4.45e-26 Body mass index; BRCA cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg03146154 chr1:46216737 IPP -0.48 -10.5 -0.38 6.87e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg21395723 chr22:39101663 GTPBP1 0.41 8.57 0.32 7.56e-17 Menopause (age at onset); BRCA cis rs3125734 0.633 rs3902162 chr10:64041817 C/T cg19640130 chr10:64028056 RTKN2 -0.32 -8.96 -0.33 3.6e-18 Rheumatoid arthritis; BRCA cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg21535247 chr6:8435926 SLC35B3 0.43 9.7 0.36 7.5e-21 Motion sickness; BRCA cis rs9443645 0.545 rs10755377 chr6:79637925 T/C cg05283184 chr6:79620031 NA -0.34 -7.99 -0.3 6.15e-15 Intelligence (multi-trait analysis); BRCA cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg00825309 chr19:58991885 ZNF446 -0.57 -12.49 -0.44 3.44e-32 Uric acid clearance; BRCA cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.11e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7103648 1.000 rs7103648 chr11:47461783 A/G cg20307385 chr11:47447363 PSMC3 0.89 27.06 0.73 4.95e-108 Diastolic blood pressure;Systolic blood pressure; BRCA trans rs61931739 0.534 rs10844801 chr12:34230940 A/T cg26384229 chr12:38710491 ALG10B 0.63 13.28 0.47 9.95e-36 Morning vs. evening chronotype; BRCA cis rs1371614 0.611 rs4665920 chr2:27128834 G/A cg12368169 chr2:27073192 DPYSL5 -0.3 -8.74 -0.33 2.01e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4642101 0.765 rs4321514 chr3:12825901 C/T cg24848339 chr3:12840334 CAND2 0.43 11.47 0.41 8.05e-28 QRS complex (12-leadsum); BRCA cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg06713675 chr4:122721982 EXOSC9 -0.54 -12.51 -0.44 2.87e-32 Type 2 diabetes; BRCA cis rs881375 0.678 rs10818488 chr9:123705087 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 8.51 0.32 1.22e-16 Rheumatoid arthritis; BRCA cis rs72781680 0.716 rs2551343 chr2:24027002 C/G cg08917208 chr2:24149416 ATAD2B 0.57 9.45 0.35 6.06e-20 Lymphocyte counts; BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg02951883 chr7:2050386 MAD1L1 -0.54 -12.29 -0.44 2.69e-31 Bipolar disorder and schizophrenia; BRCA cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg08514558 chr10:81106712 PPIF 0.35 8.51 0.32 1.24e-16 Height; BRCA cis rs67460515 0.892 rs7648279 chr3:160979646 G/A cg03342759 chr3:160939853 NMD3 -0.79 -18.75 -0.6 7.85e-63 Parkinson's disease; BRCA cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg08807101 chr21:30365312 RNF160 -0.59 -14.28 -0.49 2.39e-40 Dental caries; BRCA cis rs7914558 0.966 rs12569617 chr10:104729996 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.71 0.39 1.02e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.36e-36 Mean platelet volume; BRCA cis rs3768617 0.510 rs3765521 chr1:183077615 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 17.13 0.56 1.99e-54 Fuchs's corneal dystrophy; BRCA cis rs7737355 0.504 rs31256 chr5:130828749 T/C cg06307176 chr5:131281290 NA 0.52 10.35 0.38 2.56e-23 Life satisfaction; BRCA trans rs1493916 0.905 rs12455290 chr18:31398778 A/G cg27147174 chr7:100797783 AP1S1 -0.56 -10.9 -0.4 1.69e-25 Life satisfaction; BRCA cis rs12579753 1.000 rs34894912 chr12:82228721 A/G cg07988820 chr12:82153109 PPFIA2 -0.63 -10.13 -0.37 1.78e-22 Resting heart rate; BRCA cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.42 0.32 2.56e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg08917208 chr2:24149416 ATAD2B 1.1 15.47 0.52 4.15e-46 Lymphocyte counts; BRCA cis rs7246657 0.943 rs7255996 chr19:37971699 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.65 0.36 1.2e-20 Coronary artery calcification; BRCA cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg04034577 chr2:241836375 C2orf54 -0.57 -14.0 -0.48 4.88e-39 Urinary metabolites; BRCA cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg21132104 chr15:45694354 SPATA5L1 0.73 16.29 0.54 3.75e-50 Homoarginine levels; BRCA cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg19748678 chr4:122722346 EXOSC9 0.44 9.22 0.34 4.32e-19 Type 2 diabetes; BRCA cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg12011299 chr4:100065546 ADH4 -0.51 -11.83 -0.42 2.53e-29 Alcohol dependence; BRCA cis rs6840360 0.571 rs4696100 chr4:152514242 C/T cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 6.04e-15 Intelligence (multi-trait analysis); BRCA cis rs7085104 0.700 rs10883785 chr10:104603588 A/G cg04362960 chr10:104952993 NT5C2 0.4 9.55 0.35 2.75e-20 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg06115741 chr20:33292138 TP53INP2 0.36 8.01 0.3 5.64e-15 Glomerular filtration rate (creatinine); BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13012494 chr21:47604986 C21orf56 0.46 9.52 0.35 3.47e-20 Testicular germ cell tumor; BRCA cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.76 -0.33 1.69e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg05707623 chr12:122985044 ZCCHC8 -0.4 -8.33 -0.31 4.95e-16 Body mass index; BRCA cis rs61931739 0.500 rs11053261 chr12:34530810 C/T cg06521331 chr12:34319734 NA -0.56 -9.97 -0.37 7.13e-22 Morning vs. evening chronotype; BRCA trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.02 0.3 4.99e-15 Corneal astigmatism; BRCA cis rs1865760 0.508 rs9379820 chr6:26049924 T/C cg16482183 chr6:26056742 HIST1H1C 0.56 11.86 0.42 1.79e-29 Height; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg26608667 chr7:1196370 ZFAND2A 0.42 9.47 0.35 5.12e-20 Longevity;Endometriosis; BRCA cis rs10463316 0.894 rs7710277 chr5:150767405 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.17e-16 Metabolite levels (Pyroglutamine); BRCA cis rs11958404 0.932 rs11949394 chr5:157425198 A/G cg05962755 chr5:157440814 NA 0.52 9.99 0.37 6.23e-22 IgG glycosylation; BRCA trans rs208520 0.526 rs9351542 chr6:66788571 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.15 -39.43 -0.84 2.74e-173 Exhaled nitric oxide output; BRCA cis rs11809207 0.574 rs2783631 chr1:26504756 C/T cg23602478 chr1:26503979 CNKSR1 0.24 8.16 0.31 1.73e-15 Height; BRCA trans rs1493916 0.967 rs34341086 chr18:31400141 C/T cg15819921 chr19:927150 ARID3A -0.45 -8.48 -0.32 1.57e-16 Life satisfaction; BRCA cis rs17490626 0.512 rs12241097 chr10:71216678 T/G cg12610070 chr10:71211762 TSPAN15 -0.33 -11.47 -0.41 7.83e-28 Thrombosis; BRCA cis rs68170813 0.559 rs4730223 chr7:106814234 A/T cg02696742 chr7:106810147 HBP1 0.51 8.73 0.33 2.15e-17 Coronary artery disease; BRCA trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg27147174 chr7:100797783 AP1S1 -0.58 -11.87 -0.43 1.7e-29 Life satisfaction; BRCA cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg24549020 chr5:56110836 MAP3K1 0.64 12.87 0.45 7.13e-34 Initial pursuit acceleration; BRCA cis rs2481665 0.772 rs6668421 chr1:62536619 C/G cg18591186 chr1:62594603 INADL -0.56 -12.17 -0.43 8.89e-31 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg08000102 chr2:233561755 GIGYF2 0.45 9.72 0.36 6.19e-21 Coronary artery disease; BRCA cis rs992157 0.798 rs10932772 chr2:219177148 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.52 11.56 0.42 3.39e-28 Colorectal cancer; BRCA cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg27129171 chr3:47204927 SETD2 -0.49 -10.54 -0.38 4.65e-24 Birth weight; BRCA cis rs941764 0.965 rs747159 chr14:91841030 A/C cg10511902 chr14:91842949 CCDC88C -0.54 -14.2 -0.49 5.87e-40 Breast cancer; BRCA cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg06494592 chr3:125709126 NA -0.53 -8.25 -0.31 9.2e-16 Blood pressure (smoking interaction); BRCA cis rs877529 1.000 rs139401 chr22:39546074 C/G cg12193277 chr22:39547181 CBX7 0.46 12.72 0.45 3.21e-33 Multiple myeloma; BRCA cis rs8180040 1.000 rs553989 chr3:47400328 A/G cg27129171 chr3:47204927 SETD2 -0.71 -17.57 -0.57 1.12e-56 Colorectal cancer; BRCA cis rs10504073 0.647 rs12549138 chr8:50007203 C/T cg00325661 chr8:49890786 NA 0.44 12.45 0.44 4.95e-32 Blood metabolite ratios; BRCA cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg23711669 chr6:146136114 FBXO30 -0.78 -18.09 -0.58 2.33e-59 Lobe attachment (rater-scored or self-reported); BRCA trans rs2204008 0.777 rs8189597 chr12:38307739 G/C cg06521331 chr12:34319734 NA 0.52 9.43 0.35 7.17e-20 Bladder cancer; BRCA cis rs6570726 0.935 rs411641 chr6:145827532 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.06 0.51 4.43e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs35110281 0.774 rs162344 chr21:44954522 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.0 0.3 6.04e-15 Mean corpuscular volume; BRCA cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg08000102 chr2:233561755 GIGYF2 0.62 13.53 0.47 7.54e-37 Coronary artery disease; BRCA cis rs4285028 0.847 rs1986712 chr3:121710986 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.6 -10.5 -0.38 6.83e-24 Multiple sclerosis; BRCA cis rs10197940 0.662 rs2432945 chr2:152278414 T/C cg19508488 chr2:152266495 RIF1 0.43 9.34 0.35 1.63e-19 Lung cancer; BRCA cis rs7617773 0.780 rs11130164 chr3:48369034 G/A cg11946769 chr3:48343235 NME6 0.67 13.61 0.47 3.13e-37 Coronary artery disease; BRCA cis rs9359856 0.623 rs1179903 chr6:90321736 G/T cg13799429 chr6:90582589 CASP8AP2 -0.55 -9.34 -0.35 1.58e-19 Bipolar disorder; BRCA cis rs13046373 0.535 rs2226377 chr21:32031915 T/C cg16812893 chr21:31813075 KRTAP15-1 0.37 8.99 0.34 2.78e-18 HDL cholesterol; BRCA cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.03 -0.3 4.72e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg07148914 chr20:33460835 GGT7 -0.41 -8.91 -0.33 5.12e-18 Height; BRCA cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg13010199 chr12:38710504 ALG10B 0.56 12.22 0.44 5.11e-31 Heart rate; BRCA cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg24562669 chr7:97807699 LMTK2 0.45 12.01 0.43 4.07e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg07148914 chr20:33460835 GGT7 0.38 8.63 0.32 4.83e-17 Height; BRCA cis rs2635047 0.624 rs2289036 chr18:44595809 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.36 -7.96 -0.3 8.13e-15 Educational attainment; BRCA cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -8.86 -0.33 7.71e-18 Bipolar disorder and schizophrenia; BRCA cis rs10992471 0.528 rs2296666 chr9:95274261 C/T cg14631576 chr9:95140430 CENPP 0.33 8.23 0.31 1.04e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg03433033 chr1:76189801 ACADM 0.65 13.93 0.48 1.04e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11098499 0.820 rs11737395 chr4:120520704 C/G cg09307838 chr4:120376055 NA 0.7 14.28 0.49 2.45e-40 Corneal astigmatism; BRCA cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1.01e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6060717 0.536 rs6060676 chr20:34498551 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.24 -0.31 1e-15 Hip circumference adjusted for BMI; BRCA cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg06064525 chr11:970664 AP2A2 -0.29 -8.51 -0.32 1.24e-16 Alzheimer's disease (late onset); BRCA cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg10523679 chr1:76189770 ACADM -0.53 -9.82 -0.36 2.67e-21 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs9467711 0.790 rs34107459 chr6:26328353 T/C cg01620082 chr3:125678407 NA -0.83 -9.04 -0.34 1.78e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs1577917 0.771 rs3812133 chr6:86354411 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -12.99 -0.46 2.19e-34 Response to antipsychotic treatment; BRCA cis rs61931739 0.534 rs10844728 chr12:34020109 G/C cg06521331 chr12:34319734 NA -0.62 -11.23 -0.41 7.8e-27 Morning vs. evening chronotype; BRCA cis rs495337 0.730 rs648095 chr20:48494178 G/A cg17835207 chr20:48524531 SPATA2 -0.5 -10.5 -0.38 6.42e-24 Psoriasis; BRCA cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg08000102 chr2:233561755 GIGYF2 -0.47 -10.24 -0.38 6.78e-23 Coronary artery disease; BRCA cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.78 -0.42 4.01e-29 Bipolar disorder; BRCA cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg01579765 chr21:45077557 HSF2BP -0.4 -10.67 -0.39 1.44e-24 Mean corpuscular volume; BRCA cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg02475777 chr4:1388615 CRIPAK 0.67 12.68 0.45 5.08e-33 Longevity; BRCA trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg15556689 chr8:8085844 FLJ10661 -0.35 -9.16 -0.34 6.89e-19 Neuroticism; BRCA cis rs7635838 0.617 rs2606731 chr3:11291615 A/C cg00170343 chr3:11313890 ATG7 0.42 8.22 0.31 1.11e-15 HDL cholesterol; BRCA cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg24060327 chr5:131705240 SLC22A5 0.62 12.02 0.43 3.72e-30 Breast cancer; BRCA cis rs4853036 1.000 rs34587942 chr2:70081501 G/A cg02498382 chr2:70120550 SNRNP27 -0.49 -8.99 -0.34 2.74e-18 Colorectal or endometrial cancer; BRCA cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.23e-22 Bladder cancer; BRCA cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg06784218 chr1:46089804 CCDC17 0.52 12.53 0.44 2.24e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg00409905 chr10:38381863 ZNF37A -0.56 -12.31 -0.44 2.08e-31 Extrinsic epigenetic age acceleration; BRCA cis rs9469578 1.000 rs73743336 chr6:33715391 G/A cg18708504 chr6:33715942 IP6K3 0.7 10.19 0.37 1.09e-22 Phosphorus levels; BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 9.82 0.36 2.71e-21 Tonsillectomy; BRCA cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg18230493 chr5:56204884 C5orf35 -0.72 -13.87 -0.48 1.95e-38 Initial pursuit acceleration; BRCA cis rs4363385 0.747 rs4845330 chr1:152981505 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.82e-16 Inflammatory skin disease; BRCA cis rs7762018 0.943 rs11546265 chr6:170108363 G/A cg19338460 chr6:170058176 WDR27 -0.44 -7.83 -0.3 2.04e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs4363385 0.747 rs11205151 chr1:152961496 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.34 -0.35 1.55e-19 Inflammatory skin disease; BRCA cis rs3733585 0.699 rs7658170 chr4:9966593 C/T cg00071950 chr4:10020882 SLC2A9 0.43 10.12 0.37 2.07e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg12667521 chr19:29218732 NA 0.45 8.41 0.32 2.77e-16 Methadone dose in opioid dependence; BRCA cis rs7267979 0.966 rs6037103 chr20:25369095 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.64 -0.32 4.54e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9486719 0.857 rs2971606 chr6:97043025 C/G cg06623918 chr6:96969491 KIAA0776 -0.75 -16.57 -0.55 1.37e-51 Migraine;Coronary artery disease; BRCA cis rs16867321 0.639 rs12466864 chr2:181441417 C/G cg23363182 chr2:181467187 NA 0.47 10.3 0.38 4.2e-23 Obesity; BRCA cis rs34779708 0.966 rs10827487 chr10:35406878 T/A cg03585969 chr10:35415529 CREM 0.5 10.43 0.38 1.26e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg10729496 chr3:10149963 C3orf24 0.49 9.17 0.34 6.54e-19 Alzheimer's disease; BRCA cis rs9311474 1.000 rs6445358 chr3:52308845 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.28 8.75 0.33 1.85e-17 Electroencephalogram traits; BRCA cis rs10751667 1.000 rs7395691 chr11:985006 T/C cg10932868 chr11:921992 NA 0.41 9.81 0.36 2.99e-21 Alzheimer's disease (late onset); BRCA trans rs7615952 0.688 rs17334074 chr3:125540460 A/G cg07211511 chr3:129823064 LOC729375 0.75 14.65 0.5 3.9e-42 Blood pressure (smoking interaction); BRCA cis rs858239 0.539 rs1358442 chr7:23189739 C/T cg23682824 chr7:23144976 KLHL7 0.42 10.96 0.4 1e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs1506636 1.000 rs2215553 chr7:123318478 G/T cg03229431 chr7:123269106 ASB15 -0.63 -14.19 -0.49 6.18e-40 Plateletcrit;Platelet count; BRCA cis rs2404602 0.647 rs12898810 chr15:76904738 T/C cg23625390 chr15:77176239 SCAPER -0.54 -12.48 -0.44 3.92e-32 Blood metabolite levels; BRCA cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg24110177 chr3:50126178 RBM5 0.51 14.42 0.5 4.95e-41 Body mass index; BRCA cis rs826838 1.000 rs826891 chr12:39100824 A/G cg26384229 chr12:38710491 ALG10B -0.62 -16.18 -0.54 1.39e-49 Heart rate; BRCA cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.23 0.31 1.03e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7312933 0.585 rs7969814 chr12:42669657 C/G cg01256987 chr12:42539512 GXYLT1 -0.41 -8.11 -0.31 2.66e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6484504 0.652 rs674035 chr11:31399014 G/A cg06552810 chr11:31128660 NA 0.39 8.5 0.32 1.38e-16 Red blood cell count; BRCA cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg10802521 chr3:52805072 NEK4 -0.32 -8.42 -0.32 2.5e-16 Bipolar disorder; BRCA cis rs3857067 0.806 rs4693002 chr4:95115302 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.46 -0.35 5.77e-20 QT interval; BRCA cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.65 0.55 5.99e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 19.65 0.61 1.42e-67 Platelet count; BRCA cis rs10751667 1.000 rs4074232 chr11:977682 C/G cg06064525 chr11:970664 AP2A2 -0.34 -10.35 -0.38 2.52e-23 Alzheimer's disease (late onset); BRCA trans rs7980799 0.591 rs10844614 chr12:33605702 A/C cg26384229 chr12:38710491 ALG10B -0.51 -10.65 -0.39 1.78e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs9612 1.000 rs12669 chr19:44235535 G/A cg08581076 chr19:44259116 C19orf61 0.62 10.93 0.4 1.3e-25 Exhaled nitric oxide output; BRCA cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.37 -8.12 -0.31 2.36e-15 Alzheimer's disease (late onset); BRCA cis rs10267417 0.603 rs1557773 chr7:19908586 A/G cg05791153 chr7:19748676 TWISTNB -0.46 -9.03 -0.34 1.96e-18 Night sleep phenotypes; BRCA cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg18132916 chr6:79620363 NA -0.48 -10.89 -0.4 1.89e-25 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.718 rs1599383 chr3:160829820 T/C cg04691961 chr3:161091175 C3orf57 -0.37 -8.15 -0.31 1.89e-15 Morning vs. evening chronotype; BRCA cis rs4690686 0.500 rs12498752 chr4:177265451 T/C cg17059388 chr4:177262070 NA 0.51 10.68 0.39 1.34e-24 Essential tremor; BRCA cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg07606381 chr6:8435919 SLC35B3 0.65 14.32 0.49 1.55e-40 Motion sickness; BRCA cis rs77972916 0.505 rs3851318 chr2:43532808 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.63 -10.71 -0.39 1.01e-24 Granulocyte percentage of myeloid white cells; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg08888203 chr3:10149979 C3orf24 0.68 14.5 0.5 2.22e-41 Alzheimer's disease; BRCA cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg24076588 chr1:18808559 KLHDC7A -0.45 -10.5 -0.38 6.61e-24 Breast cancer; BRCA cis rs3772130 0.775 rs6781857 chr3:121560721 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.74 0.39 7.27e-25 Cognitive performance; BRCA cis rs7647973 1.000 rs7647973 chr3:49510931 G/A cg07636037 chr3:49044803 WDR6 -0.77 -15.58 -0.52 1.28e-46 Menarche (age at onset); BRCA cis rs2645694 0.626 rs2703151 chr4:77834095 A/G cg06046430 chr4:77819534 ANKRD56 0.51 11.08 0.4 3.12e-26 Emphysema distribution in smoking; BRCA cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.68 -14.0 -0.48 4.85e-39 Chronic sinus infection; BRCA cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg05535760 chr7:792225 HEATR2 0.72 13.05 0.46 1.09e-34 Cerebrospinal P-tau181p levels; BRCA cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg05623727 chr3:50126028 RBM5 -0.43 -10.25 -0.38 6.46e-23 Intelligence (multi-trait analysis); BRCA cis rs3739998 0.647 rs7920682 chr10:30317826 C/T cg00730780 chr10:30316187 KIAA1462 -0.55 -11.79 -0.42 3.68e-29 Coronary heart disease; BRCA cis rs17209837 0.607 rs2888611 chr7:87103670 C/G cg00919237 chr7:87102261 ABCB4 0.54 10.53 0.38 5.29e-24 Gallbladder cancer; BRCA cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg11752832 chr7:134001865 SLC35B4 0.53 13.75 0.48 7.41e-38 Mean platelet volume; BRCA cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg11764359 chr7:65958608 NA -0.79 -18.91 -0.6 1.14e-63 Aortic root size; BRCA cis rs17376456 0.825 rs72786702 chr5:93254656 A/C cg21475434 chr5:93447410 FAM172A 0.66 8.55 0.32 8.79e-17 Diabetic retinopathy; BRCA cis rs1801251 0.896 rs2197563 chr2:233687080 G/A cg25237894 chr2:233734115 C2orf82 -0.38 -11.01 -0.4 6.31e-26 Coronary artery disease; BRCA cis rs4363385 0.818 rs11205175 chr1:153001296 A/C cg24667326 chr1:152973720 SPRR3 -0.33 -8.77 -0.33 1.55e-17 Inflammatory skin disease; BRCA cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 9.15 0.34 7.34e-19 Personality dimensions; BRCA cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg14061069 chr19:46274453 DMPK -0.48 -11.94 -0.43 8.25e-30 Coronary artery disease; BRCA cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs701145 0.585 rs447429 chr3:153909946 T/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs875971 0.862 rs778684 chr7:65836403 A/T cg18876405 chr7:65276391 NA 0.52 11.63 0.42 1.7e-28 Aortic root size; BRCA cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg02187348 chr16:89574699 SPG7 0.51 12.04 0.43 3.2e-30 Multiple myeloma (IgH translocation); BRCA cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg03433033 chr1:76189801 ACADM 0.76 17.39 0.57 9.02e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg08704250 chr15:31115839 NA -0.38 -9.28 -0.34 2.59e-19 Huntington's disease progression; BRCA cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg02574844 chr11:5959923 NA -0.39 -8.06 -0.3 3.7e-15 DNA methylation (variation); BRCA cis rs6582630 0.555 rs61932279 chr12:38349096 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.63 -0.36 1.37e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs7944584 0.511 rs10838731 chr11:47607135 C/T cg03711944 chr11:47377212 SPI1 -0.41 -9.76 -0.36 4.58e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs60843830 0.661 rs7588043 chr2:104979 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.67 0.32 3.43e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg27398817 chr8:82754497 SNX16 0.35 8.05 0.3 4.1e-15 Diastolic blood pressure; BRCA cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg05623727 chr3:50126028 RBM5 -0.43 -10.39 -0.38 1.82e-23 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs1577965 chr1:152968294 T/C cg21543102 chr1:152974771 SPRR3 -0.3 -8.36 -0.31 3.79e-16 Inflammatory skin disease; BRCA cis rs6435161 0.959 rs1971740 chr2:203484736 G/A cg18429434 chr2:203499731 FAM117B -0.43 -9.0 -0.34 2.46e-18 Total cholesterol levels; BRCA cis rs60843830 0.661 rs11674477 chr2:105822 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.49 9.31 0.35 2.01e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs897984 0.762 rs897986 chr16:30980902 T/C cg02466173 chr16:30829666 NA 0.49 11.14 0.4 1.89e-26 Dementia with Lewy bodies; BRCA cis rs1113500 0.836 rs2801220 chr1:108584649 A/G cg06207961 chr1:108661230 NA -0.4 -9.72 -0.36 6.31e-21 Growth-regulated protein alpha levels; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg24642844 chr7:1081250 C7orf50 -0.57 -11.6 -0.42 2.36e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11190604 0.943 rs3750632 chr10:102279295 G/C cg07080220 chr10:102295463 HIF1AN 0.61 14.33 0.49 1.36e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg22535103 chr8:58192502 C8orf71 0.46 9.19 0.34 5.29e-19 Developmental language disorder (linguistic errors); BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.59 9.27 0.34 2.74e-19 Renal function-related traits (BUN); BRCA cis rs55692411 0.537 rs13071931 chr3:50062878 G/A cg24110177 chr3:50126178 RBM5 -0.44 -9.69 -0.36 8.62e-21 Intelligence (multi-trait analysis); BRCA cis rs7580658 0.963 rs12052483 chr2:128136820 T/G cg09760422 chr2:128146352 NA -0.35 -7.84 -0.3 1.83e-14 Protein C levels; BRCA cis rs4423214 0.879 rs736894 chr11:71152258 A/G cg05163923 chr11:71159392 DHCR7 0.58 12.02 0.43 3.88e-30 Vitamin D levels; BRCA cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 9.03 0.34 2.05e-18 Personality dimensions; BRCA cis rs733175 0.855 rs10023068 chr4:10004832 C/T cg00071950 chr4:10020882 SLC2A9 -0.41 -8.69 -0.33 3.06e-17 Psychosis and Alzheimer's disease; BRCA trans rs62103177 0.525 rs4283293 chr18:77759582 A/G cg05926928 chr17:57297772 GDPD1 -0.59 -9.1 -0.34 1.13e-18 Opioid sensitivity; BRCA cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.16 -0.43 9.45e-31 Electroencephalogram traits; BRCA cis rs7474896 0.583 rs11011347 chr10:38019264 G/A cg25427524 chr10:38739819 LOC399744 -0.53 -9.45 -0.35 6.42e-20 Obesity (extreme); BRCA cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.75 0.57 1.29e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.41 -7.92 -0.3 1.06e-14 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs11727653 chr4:99001774 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs17253792 0.915 rs78498383 chr14:56177585 C/T cg01858014 chr14:56050164 KTN1 -0.67 -8.52 -0.32 1.13e-16 Putamen volume; BRCA trans rs35110281 0.805 rs4818843 chr21:45006607 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.5 0.35 3.97e-20 Mean corpuscular volume; BRCA cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -11.75 -0.42 5.1e-29 Chronic sinus infection; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.62 12.72 0.45 3.23e-33 Lymphocyte counts; BRCA cis rs35740288 0.545 rs12916187 chr15:86326124 A/C cg20737812 chr15:86336631 KLHL25 -0.38 -8.21 -0.31 1.27e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.93e-24 Motion sickness; BRCA cis rs1215050 0.740 rs783916 chr4:99026264 A/C cg05340658 chr4:99064831 C4orf37 -0.53 -12.42 -0.44 6.89e-32 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12497850 0.931 rs9840684 chr3:48893780 T/C cg07636037 chr3:49044803 WDR6 0.97 28.32 0.75 6.46e-115 Parkinson's disease; BRCA cis rs3008870 0.755 rs2815368 chr1:67500778 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 12.98 0.46 2.36e-34 Lymphocyte percentage of white cells; BRCA cis rs6963495 0.818 rs6973263 chr7:105170293 A/G cg19920283 chr7:105172520 RINT1 0.59 9.53 0.35 3.29e-20 Bipolar disorder (body mass index interaction); BRCA cis rs597539 0.652 rs584108 chr11:68630282 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.7 -16.18 -0.54 1.39e-49 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.53 11.74 0.42 6.18e-29 Multiple sclerosis; BRCA cis rs778371 0.958 rs778341 chr2:233728801 C/A cg08000102 chr2:233561755 GIGYF2 -0.74 -15.68 -0.53 4.11e-47 Schizophrenia; BRCA cis rs6754459 0.603 rs11894441 chr2:3701972 A/G cg00999904 chr2:3704751 ALLC 0.38 7.95 0.3 8.44e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs6963495 0.585 rs1706923 chr7:105221097 A/G cg19920283 chr7:105172520 RINT1 0.43 8.89 0.33 6.34e-18 Bipolar disorder (body mass index interaction); BRCA cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.59 -16.35 -0.54 1.85e-50 Colorectal cancer; BRCA cis rs17270561 0.636 rs9379782 chr6:25715023 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.85 0.33 8.66e-18 Iron status biomarkers; BRCA cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg06547715 chr2:218990976 CXCR2 0.32 8.03 0.3 4.54e-15 Ulcerative colitis; BRCA cis rs7953508 0.506 rs3869308 chr12:93959918 A/G cg18151635 chr12:93972918 NA -0.48 -9.71 -0.36 7.02e-21 Pubertal anthropometrics; BRCA cis rs250677 0.522 rs4562031 chr5:148368451 A/G cg18129178 chr5:148520854 ABLIM3 0.55 10.53 0.38 5.11e-24 Breast cancer; BRCA cis rs9527 0.590 rs1926029 chr10:104855670 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.11 0.37 2.26e-22 Arsenic metabolism; BRCA cis rs7726839 0.526 rs11960159 chr5:568685 C/T cg09021430 chr5:549028 NA -0.61 -15.75 -0.53 1.83e-47 Obesity-related traits; BRCA cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.08 -0.3 3.23e-15 Blood pressure (smoking interaction); BRCA cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg16339924 chr4:17578868 LAP3 0.64 16.14 0.54 2.19e-49 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -8.8 -0.33 1.3e-17 Bipolar disorder and schizophrenia; BRCA cis rs9837602 0.683 rs9825882 chr3:99906250 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -8.39 -0.32 3.01e-16 Breast cancer; BRCA cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg09184832 chr6:79620586 NA -0.52 -11.41 -0.41 1.44e-27 Intelligence (multi-trait analysis); BRCA cis rs6840258 0.660 rs72667741 chr4:87892075 T/C cg08197287 chr4:87952173 AFF1 -0.46 -8.39 -0.31 3.18e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg14926445 chr8:58193284 C8orf71 -0.44 -8.07 -0.3 3.57e-15 Developmental language disorder (linguistic errors); BRCA cis rs10465746 0.725 rs2024591 chr1:84329235 C/T cg10977910 chr1:84465055 TTLL7 0.59 12.02 0.43 3.67e-30 Obesity-related traits; BRCA cis rs16854884 0.770 rs1530478 chr3:143819553 C/T cg06585982 chr3:143692056 C3orf58 0.42 8.34 0.31 4.56e-16 Economic and political preferences (feminism/equality); BRCA cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg14349672 chr11:133703707 NA -0.42 -9.17 -0.34 6.16e-19 Childhood ear infection; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg21782813 chr7:2030301 MAD1L1 0.4 10.75 0.39 7.06e-25 Bipolar disorder and schizophrenia; BRCA cis rs9443189 1.000 rs3822957 chr6:76607280 A/G cg01950844 chr6:76311363 SENP6 -0.59 -9.3 -0.35 2.29e-19 Prostate cancer; BRCA cis rs10992471 0.603 rs10820968 chr9:95106443 A/G cg14631576 chr9:95140430 CENPP -0.39 -9.58 -0.35 2.04e-20 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg00757033 chr12:89920650 WDR51B 0.51 10.75 0.39 6.81e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6665290 0.582 rs72764213 chr1:227207391 C/T cg10327440 chr1:227177885 CDC42BPA -1.12 -39.61 -0.84 3.43e-174 Myeloid white cell count; BRCA cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.47 0.35 5.18e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4812048 0.649 rs116580814 chr20:57618141 G/T cg14073986 chr20:57617431 SLMO2 0.81 11.24 0.41 7.36e-27 Mean platelet volume; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg22907277 chr7:1156413 C7orf50 0.63 10.98 0.4 8.4e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs9650657 0.644 rs4395858 chr8:10521021 C/T cg06636001 chr8:8085503 FLJ10661 0.55 11.6 0.42 2.2e-28 Neuroticism; BRCA cis rs9462027 0.628 rs2764198 chr6:34706128 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA cis rs11190604 1.000 rs2489035 chr10:102319395 C/T cg07080220 chr10:102295463 HIF1AN 0.59 13.77 0.48 5.59e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg09184832 chr6:79620586 NA -0.52 -11.41 -0.41 1.44e-27 Intelligence (multi-trait analysis); BRCA trans rs72766638 0.848 rs11789898 chr9:136925663 A/C cg09836344 chr4:1243392 C4orf42;CTBP1 0.66 9.84 0.36 2.34e-21 Mosquito bite size; BRCA cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg17724175 chr1:150552817 MCL1 0.25 8.27 0.31 7.75e-16 Melanoma; BRCA cis rs7127900 0.583 rs11043147 chr11:2234169 C/G cg25635251 chr11:2234043 NA 0.46 13.12 0.46 5.55e-35 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); BRCA cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg06784218 chr1:46089804 CCDC17 0.46 10.91 0.4 1.58e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs587242 0.955 rs35251373 chr1:96970538 C/T cg10631902 chr5:14652156 NA 0.43 10.63 0.39 2.1e-24 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg06640241 chr16:89574553 SPG7 -0.77 -19.19 -0.6 3.66e-65 Multiple myeloma (IgH translocation); BRCA cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.99 -0.33 2.87e-18 Alzheimer's disease (late onset); BRCA cis rs6570726 0.935 rs391524 chr6:145823844 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7246657 0.550 rs10411176 chr19:37686953 G/T cg18154014 chr19:37997991 ZNF793 0.56 9.33 0.35 1.69e-19 Coronary artery calcification; BRCA cis rs11190604 0.767 rs4919458 chr10:102177728 G/A cg07080220 chr10:102295463 HIF1AN -0.46 -10.37 -0.38 2.16e-23 Palmitoleic acid (16:1n-7) levels; BRCA trans rs3857536 0.813 rs9360189 chr6:66933424 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.11 -0.31 2.53e-15 Blood trace element (Cu levels); BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg18765753 chr7:1198926 ZFAND2A -0.33 -8.06 -0.3 3.77e-15 Longevity;Endometriosis; BRCA cis rs9633740 0.578 rs7084416 chr10:82304297 G/A cg01528321 chr10:82214614 TSPAN14 -0.66 -11.07 -0.4 3.41e-26 Post bronchodilator FEV1; BRCA cis rs2282802 0.685 rs6893253 chr5:139661279 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.15e-15 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg16102102 chr5:83017553 HAPLN1 -0.88 -17.61 -0.57 7.01e-57 Prostate cancer; BRCA cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg11764359 chr7:65958608 NA 0.76 16.82 0.55 7.85e-53 Aortic root size; BRCA cis rs1215050 0.743 rs6532692 chr4:98648005 C/A cg05340658 chr4:99064831 C4orf37 -0.41 -8.82 -0.33 1.05e-17 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11229555 0.645 rs11601296 chr11:58423297 A/G cg15696309 chr11:58395628 NA -0.49 -9.73 -0.36 5.67e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg19346786 chr7:2764209 NA -0.31 -9.14 -0.34 8.22e-19 Height; BRCA cis rs2624839 0.679 rs2624835 chr3:50209049 G/A cg24110177 chr3:50126178 RBM5 -0.48 -12.21 -0.43 5.96e-31 Intelligence (multi-trait analysis); BRCA cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg06484146 chr7:12443880 VWDE -0.6 -10.3 -0.38 4.07e-23 Coronary artery disease; BRCA cis rs2625529 0.668 rs8192431 chr15:72492352 G/A cg16672083 chr15:72433130 SENP8 -0.85 -17.4 -0.57 8.61e-56 Red blood cell count; BRCA trans rs11098499 0.866 rs9991221 chr4:120292107 G/C cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs7809950 0.834 rs2712199 chr7:107140239 A/G cg23024343 chr7:107201750 COG5 -0.4 -9.09 -0.34 1.21e-18 Coronary artery disease; BRCA cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg16479474 chr6:28041457 NA 0.42 7.81 0.3 2.41e-14 Parkinson's disease; BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg08888203 chr3:10149979 C3orf24 0.53 9.89 0.36 1.44e-21 Alzheimer's disease; BRCA cis rs6964587 1.000 rs28584017 chr7:91719168 G/A cg17063962 chr7:91808500 NA 0.53 12.48 0.44 3.92e-32 Breast cancer; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg04013093 chr6:42928303 GNMT -0.29 -8.9 -0.33 5.73e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA trans rs61931739 0.517 rs34760282 chr12:34153711 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.66 0.36 1.03e-20 Morning vs. evening chronotype; BRCA trans rs7824557 0.767 rs6991606 chr8:11176159 G/A cg15556689 chr8:8085844 FLJ10661 0.39 9.2 0.34 4.92e-19 Retinal vascular caliber; BRCA cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.78e-15 Breast cancer; BRCA cis rs9399135 0.935 rs2150680 chr6:135347131 G/C cg24558204 chr6:135376177 HBS1L 0.45 12.41 0.44 8.13e-32 Red blood cell count; BRCA cis rs2806561 0.606 rs10917335 chr1:23294136 A/G cg19743168 chr1:23544995 NA 0.34 7.83 0.3 2.05e-14 Height; BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg08470875 chr2:26401718 FAM59B 0.64 8.65 0.32 4.04e-17 Gut microbiome composition (summer); BRCA cis rs1568889 0.938 rs6484358 chr11:28260364 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.71 0.5 2.04e-42 Bipolar disorder; BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 18.25 0.59 3.13e-60 Alzheimer's disease; BRCA cis rs614226 1.000 rs580016 chr12:120933977 T/C cg01236616 chr12:121019343 POP5 -1.22 -23.09 -0.67 3e-86 Type 1 diabetes nephropathy; BRCA cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg04756594 chr16:24857601 SLC5A11 -0.55 -12.24 -0.44 4.24e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg21427119 chr20:30132790 HM13 -0.42 -8.85 -0.33 8.22e-18 Mean corpuscular hemoglobin; BRCA cis rs13191362 0.808 rs13217502 chr6:163231414 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.63 9.43 0.35 7.29e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs709400 0.663 rs7152202 chr14:103886757 A/G cg12935359 chr14:103987150 CKB -0.59 -14.08 -0.49 1.99e-39 Body mass index; BRCA cis rs1577917 0.545 rs1832070 chr6:86483172 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.34 9.19 0.34 5.44e-19 Response to antipsychotic treatment; BRCA cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg26384229 chr12:38710491 ALG10B 0.75 17.2 0.56 8.96e-55 Bladder cancer; BRCA cis rs7258465 1.000 rs2303695 chr19:18562624 C/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.93 -0.33 4.44e-18 Breast cancer; BRCA cis rs6594499 0.872 rs10055177 chr5:110450584 T/G cg04022379 chr5:110408740 TSLP 0.35 7.95 0.3 8.57e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs611744 0.647 rs9969614 chr8:109260581 A/G cg21045802 chr8:109455806 TTC35 0.35 8.35 0.31 4.22e-16 Dupuytren's disease; BRCA cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg06636001 chr8:8085503 FLJ10661 0.6 13.29 0.47 9.61e-36 Mood instability; BRCA cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03517284 chr6:25882590 NA -0.44 -9.25 -0.34 3.24e-19 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.931 rs2505631 chr10:35368385 A/T cg03585969 chr10:35415529 CREM -0.45 -9.65 -0.36 1.15e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 19.97 0.62 2.63e-69 Platelet count; BRCA cis rs897984 0.609 rs1108431 chr16:31054607 C/T cg00531865 chr16:30841666 NA -0.4 -9.41 -0.35 9.14e-20 Dementia with Lewy bodies; BRCA cis rs2404602 0.716 rs12594577 chr15:76828793 A/C cg23625390 chr15:77176239 SCAPER 0.39 9.14 0.34 8.44e-19 Blood metabolite levels; BRCA cis rs877282 0.891 rs11599917 chr10:762288 G/A cg17470449 chr10:769945 NA 0.47 8.12 0.31 2.39e-15 Uric acid levels; BRCA cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg24642439 chr20:33292090 TP53INP2 0.56 12.17 0.43 8.41e-31 Coronary artery disease; BRCA cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg12573674 chr2:1569213 NA -0.56 -12.3 -0.44 2.4e-31 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs953387 1.000 rs953387 chr2:136907170 A/C cg05194412 chr2:137003533 NA -0.37 -8.5 -0.32 1.31e-16 Arthritis (juvenile idiopathic); BRCA cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg08000102 chr2:233561755 GIGYF2 -0.45 -9.67 -0.36 9.49e-21 Coronary artery disease; BRCA cis rs12911832 1.000 rs4774310 chr15:58985164 T/G cg05156742 chr15:59063176 FAM63B 0.5 9.94 0.37 9.34e-22 Schizophrenia; BRCA cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg04586622 chr2:25135609 ADCY3 0.46 11.59 0.42 2.61e-28 Body mass index; BRCA cis rs10754283 0.905 rs7519969 chr1:90108721 G/C cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs11098499 0.863 rs3775858 chr4:120486028 A/G cg09307838 chr4:120376055 NA 0.69 14.88 0.51 3.23e-43 Corneal astigmatism; BRCA trans rs2797160 0.684 rs1832937 chr6:125985934 A/G cg05039488 chr6:79577232 IRAK1BP1 0.39 9.05 0.34 1.77e-18 Endometrial cancer; BRCA cis rs1577917 0.682 rs1173419 chr6:86402163 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.34 -9.6 -0.36 1.75e-20 Response to antipsychotic treatment; BRCA cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg03808351 chr9:123631620 PHF19 -0.6 -10.12 -0.37 2.04e-22 Birth weight; BRCA cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg05535760 chr7:792225 HEATR2 0.85 14.21 0.49 4.98e-40 Cerebrospinal P-tau181p levels; BRCA cis rs2795502 0.564 rs72777187 chr10:43432224 C/T cg08461752 chr10:43522343 NA -0.48 -8.63 -0.32 4.91e-17 Blood protein levels; BRCA cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 14.97 0.51 1.2e-43 Hip circumference adjusted for BMI; BRCA cis rs3617 0.625 rs11715347 chr3:52883070 C/T cg11645453 chr3:52864694 ITIH4 -0.37 -9.92 -0.37 1.17e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg24829409 chr8:58192753 C8orf71 -0.5 -11.06 -0.4 3.77e-26 Developmental language disorder (linguistic errors); BRCA cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.64 0.32 4.6e-17 Morning vs. evening chronotype; BRCA cis rs4803468 1.000 rs10417997 chr19:41902361 G/A cg09537434 chr19:41945824 ATP5SL -0.98 -24.68 -0.7 5.66e-95 Height; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg17158414 chr2:27665306 KRTCAP3 0.35 9.23 0.34 3.84e-19 Total body bone mineral density; BRCA cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.54 -0.52 1.92e-46 Systemic lupus erythematosus; BRCA cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg11266682 chr4:10021025 SLC2A9 -0.42 -11.06 -0.4 4.01e-26 Bone mineral density; BRCA cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg24209194 chr3:40518798 ZNF619 -0.4 -8.3 -0.31 6.37e-16 Renal cell carcinoma; BRCA cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg18876405 chr7:65276391 NA -0.52 -11.7 -0.42 8.87e-29 Aortic root size; BRCA cis rs9649465 0.967 rs768680 chr7:123364127 T/C cg04330084 chr7:123175371 IQUB -0.31 -8.54 -0.32 9.74e-17 Migraine; BRCA cis rs9814567 1.000 rs6763093 chr3:134254995 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7914558 0.933 rs10786729 chr10:104719378 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.54 0.38 4.65e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg03354898 chr7:1950403 MAD1L1 -0.5 -11.06 -0.4 3.79e-26 Bipolar disorder and schizophrenia; BRCA cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg27211696 chr2:191398769 TMEM194B 0.52 11.89 0.43 1.36e-29 Pulse pressure; BRCA cis rs11662586 0.517 rs11663082 chr18:77713494 C/T cg20368463 chr18:77673604 PQLC1 0.47 11.6 0.42 2.24e-28 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -13.25 -0.46 1.46e-35 Bipolar disorder and schizophrenia; BRCA cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg11822812 chr5:140052017 DND1 -0.31 -8.4 -0.32 2.86e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs701145 0.938 rs357504 chr3:153956857 A/C cg17054900 chr3:154042577 DHX36 0.67 11.86 0.42 1.91e-29 Coronary artery disease; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg23285459 chr7:2802560 GNA12 -0.31 -8.11 -0.31 2.54e-15 Height; BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg22376730 chr1:1715039 NA 0.34 8.88 0.33 6.81e-18 Body mass index; BRCA trans rs6833159 0.527 rs10939231 chr4:28829372 A/T cg25803693 chr12:82752707 CCDC59;C12orf26 0.37 8.43 0.32 2.21e-16 Underweight status; BRCA cis rs12579753 1.000 rs12821073 chr12:82183260 G/T cg07988820 chr12:82153109 PPFIA2 -0.48 -8.46 -0.32 1.8e-16 Resting heart rate; BRCA cis rs17270561 0.636 rs7775354 chr6:25745266 T/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA trans rs7819412 0.811 rs2409691 chr8:10943276 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -10.85 -0.39 2.75e-25 Triglycerides; BRCA cis rs9880211 0.948 rs6806123 chr3:136305476 C/G cg21827317 chr3:136751795 NA -0.45 -8.03 -0.3 4.53e-15 Body mass index;Height; BRCA cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg03146154 chr1:46216737 IPP -0.5 -11.11 -0.4 2.44e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs36051895 0.558 rs7038687 chr9:5134065 C/T cg02405213 chr9:5042618 JAK2 0.46 9.09 0.34 1.19e-18 Pediatric autoimmune diseases; BRCA cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg18196295 chr10:418757 DIP2C 0.49 11.86 0.42 1.87e-29 Psychosis in Alzheimer's disease; BRCA cis rs7613875 0.600 rs2624848 chr3:50165101 T/C cg24110177 chr3:50126178 RBM5 0.55 16.08 0.54 3.99e-49 Body mass index; BRCA cis rs778371 0.752 rs283487 chr2:233644011 A/G cg08000102 chr2:233561755 GIGYF2 0.78 16.91 0.56 2.66e-53 Schizophrenia; BRCA cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs7927771 1.000 rs4752856 chr11:47648042 C/T cg18512352 chr11:47633146 NA -0.38 -9.26 -0.34 3.02e-19 Subjective well-being; BRCA cis rs7267979 0.932 rs6115200 chr20:25487377 G/T cg08601574 chr20:25228251 PYGB 0.35 8.4 0.32 2.92e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7582180 0.629 rs893416 chr2:100957443 G/A cg08017756 chr2:100939284 LONRF2 -0.3 -7.84 -0.3 1.86e-14 Intelligence (multi-trait analysis); BRCA cis rs7254114 0.578 rs6511727 chr19:11315817 G/T cg02815516 chr19:11306319 KANK2 -0.33 -9.41 -0.35 8.95e-20 Immature fraction of reticulocytes; BRCA cis rs425277 0.606 rs451061 chr1:2075068 C/G cg04315214 chr1:2043799 PRKCZ -0.45 -12.63 -0.45 8.29e-33 Height; BRCA cis rs7666738 0.830 rs1967980 chr4:98966426 C/G cg17366294 chr4:99064904 C4orf37 0.44 10.31 0.38 3.67e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.6 -0.32 6e-17 Developmental language disorder (linguistic errors); BRCA cis rs2880765 0.743 rs16940052 chr15:86006674 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.27 -0.31 7.69e-16 Coronary artery disease; BRCA cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.79 11.43 0.41 1.13e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2243480 0.522 rs12698511 chr7:65474919 G/T cg18252515 chr7:66147081 NA -0.94 -10.68 -0.39 1.25e-24 Diabetic kidney disease; BRCA cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg06092702 chr1:163392909 NA -0.37 -9.8 -0.36 3.11e-21 Motion sickness; BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg08470875 chr2:26401718 FAM59B -0.64 -9.54 -0.35 2.95e-20 Gut microbiome composition (summer); BRCA cis rs9790314 0.967 rs10804790 chr3:161039300 T/A cg03342759 chr3:160939853 NMD3 -0.64 -13.56 -0.47 5.21e-37 Morning vs. evening chronotype; BRCA cis rs8014204 0.836 rs7154256 chr14:75252587 A/G cg06637938 chr14:75390232 RPS6KL1 0.55 11.14 0.4 1.89e-26 Caffeine consumption; BRCA cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.71e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504073 0.647 rs4348510 chr8:50016027 C/A cg00325661 chr8:49890786 NA 0.38 11.24 0.41 7.42e-27 Blood metabolite ratios; BRCA cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14240646 chr10:27532245 ACBD5 0.64 9.52 0.35 3.43e-20 Breast cancer; BRCA cis rs2806561 0.780 rs12135629 chr1:23338899 A/G cg19743168 chr1:23544995 NA -0.42 -10.03 -0.37 4.2e-22 Height; BRCA cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg12011299 chr4:100065546 ADH4 -0.51 -11.75 -0.42 5.1e-29 Alcohol dependence; BRCA cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg21573476 chr21:45109991 RRP1B -0.33 -8.47 -0.32 1.73e-16 Mean corpuscular volume; BRCA cis rs559928 0.606 rs11605856 chr11:63925528 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 11.34 0.41 2.88e-27 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.74 0.55 2.09e-52 Age-related macular degeneration (geographic atrophy); BRCA cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg25358565 chr5:93447407 FAM172A 1.16 18.33 0.59 1.33e-60 Diabetic retinopathy; BRCA cis rs68092024 0.704 rs792832 chr3:99474862 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.53 -0.38 5.22e-24 Cleft lip with or without cleft palate; BRCA cis rs17401966 0.931 rs2236678 chr1:10471789 A/T cg19773385 chr1:10388646 KIF1B -0.39 -8.31 -0.31 5.63e-16 Hepatocellular carcinoma; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.03 18.31 0.59 1.69e-60 Platelet count; BRCA cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg09580153 chr6:41068724 NFYA;LOC221442 0.4 9.08 0.34 1.35e-18 Alzheimer's disease (late onset); BRCA cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg04317338 chr11:64019027 PLCB3 0.55 9.48 0.35 4.9e-20 Mean platelet volume; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg27170947 chr2:26402098 FAM59B 0.97 15.4 0.52 9.96e-46 Gut microbiome composition (summer); BRCA cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg10932868 chr11:921992 NA 0.49 12.62 0.45 9.59e-33 Alzheimer's disease (late onset); BRCA cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg12463550 chr7:65579703 CRCP 0.37 7.85 0.3 1.75e-14 Aortic root size; BRCA cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg09035930 chr12:129282057 SLC15A4 0.55 16.19 0.54 1.17e-49 Systemic lupus erythematosus; BRCA cis rs3815700 1.000 rs8113165 chr19:33096316 C/T cg02997394 chr19:33096574 ANKRD27 0.71 12.28 0.44 2.75e-31 Eosinophilic esophagitis; BRCA cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg05084668 chr3:125655381 ALG1L -0.44 -7.81 -0.3 2.4e-14 Blood pressure (smoking interaction); BRCA cis rs4730250 0.655 rs75243311 chr7:106890791 C/T cg02696742 chr7:106810147 HBP1 -0.47 -7.92 -0.3 1.08e-14 Osteoarthritis; BRCA cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg21770322 chr7:97807741 LMTK2 0.44 11.72 0.42 7.34e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26314531 chr2:26401878 FAM59B -0.66 -11.29 -0.41 4.42e-27 Gut microbiome composition (summer); BRCA cis rs1707322 0.686 rs3014236 chr1:46091305 T/C cg06784218 chr1:46089804 CCDC17 -0.53 -13.0 -0.46 1.81e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10242455 0.557 rs73401516 chr7:99068351 C/A cg18809830 chr7:99032528 PTCD1 -0.58 -8.33 -0.31 4.76e-16 Blood metabolite levels; BRCA cis rs738322 0.555 rs5750547 chr22:38546700 A/G cg20207973 chr22:38506712 BAIAP2L2 -0.32 -8.1 -0.31 2.87e-15 Cutaneous nevi; BRCA cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg20503657 chr10:835505 NA -0.45 -8.89 -0.33 6.05e-18 Response to angiotensin II receptor blocker therapy; BRCA cis rs6700896 0.931 rs12042779 chr1:66133950 T/C cg04111102 chr1:66153794 NA 0.35 8.55 0.32 8.78e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg01579765 chr21:45077557 HSF2BP 0.38 10.14 0.37 1.71e-22 Mean corpuscular volume; BRCA cis rs11585357 1.000 rs72646785 chr1:17603472 G/T cg08277548 chr1:17600880 PADI3 -0.74 -12.07 -0.43 2.35e-30 Hair shape; BRCA cis rs1401999 0.966 rs2292998 chr3:183663833 T/C cg20387954 chr3:183756860 HTR3D 0.45 10.05 0.37 3.66e-22 Anterior chamber depth; BRCA cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 18.62 0.59 3.63e-62 Alzheimer's disease; BRCA cis rs79976124 0.800 rs6918860 chr6:66637741 G/C cg07460842 chr6:66804631 NA 0.59 10.46 0.38 9.37e-24 Type 2 diabetes; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg22907277 chr7:1156413 C7orf50 0.59 9.19 0.34 5.33e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs5758511 0.680 rs1107554 chr22:42667594 C/G cg00645731 chr22:42541494 CYP2D7P1 0.58 11.34 0.41 2.69e-27 Birth weight; BRCA cis rs858239 0.600 rs13438179 chr7:23143851 T/C cg23682824 chr7:23144976 KLHL7 0.45 12.23 0.44 4.53e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs5751614 0.517 rs928780 chr22:23599869 G/A cg25410636 chr22:23605411 BCR -0.35 -8.01 -0.3 5.57e-15 Height; BRCA cis rs11585357 0.557 rs17378462 chr1:17595702 C/T cg08277548 chr1:17600880 PADI3 -0.53 -8.28 -0.31 7.04e-16 Hair shape; BRCA cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg06552810 chr11:31128660 NA -0.37 -8.1 -0.31 2.87e-15 Red blood cell count; BRCA cis rs6964587 1.000 rs11982047 chr7:91705274 G/A cg17063962 chr7:91808500 NA 0.54 12.26 0.44 3.49e-31 Breast cancer; BRCA cis rs7618915 0.571 rs6798246 chr3:52599922 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.82 0.36 2.79e-21 Bipolar disorder; BRCA cis rs4319547 0.585 rs7952868 chr12:122846949 A/G cg05707623 chr12:122985044 ZCCHC8 -0.52 -9.55 -0.35 2.66e-20 Body mass index; BRCA cis rs1050631 0.657 rs1789551 chr18:33716092 G/A cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.99 -0.3 6.25e-15 Esophageal squamous cell cancer (length of survival); BRCA cis rs10504073 0.584 rs62507210 chr8:49946601 C/T cg00325661 chr8:49890786 NA 0.47 13.71 0.48 1.04e-37 Blood metabolite ratios; BRCA cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg08975724 chr8:8085496 FLJ10661 -0.47 -10.54 -0.38 4.65e-24 Mood instability; BRCA cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg21132104 chr15:45694354 SPATA5L1 0.74 16.82 0.55 7.77e-53 Homoarginine levels; BRCA cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg25237894 chr2:233734115 C2orf82 0.4 11.39 0.41 1.76e-27 Coronary artery disease; BRCA cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg00409905 chr10:38381863 ZNF37A -0.51 -10.84 -0.39 3.13e-25 Extrinsic epigenetic age acceleration; BRCA trans rs911555 0.755 rs12436729 chr14:103929889 G/C cg17675199 chr6:35436792 RPL10A -0.3 -7.88 -0.3 1.42e-14 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24110177 chr3:50126178 RBM5 -0.33 -8.93 -0.33 4.41e-18 Intelligence (multi-trait analysis); BRCA cis rs11997175 0.603 rs7464072 chr8:33776973 G/A ch.8.33884649F chr8:33765107 NA 0.38 9.01 0.34 2.29e-18 Body mass index; BRCA cis rs1003719 0.688 rs2000413 chr21:38539718 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -13.71 -0.48 1.05e-37 Eye color traits; BRCA cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg17971929 chr21:40555470 PSMG1 0.8 18.56 0.59 8.04e-62 Cognitive function; BRCA cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg20476274 chr7:133979776 SLC35B4 0.7 21.33 0.64 1.22e-76 Mean platelet volume; BRCA cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg16339924 chr4:17578868 LAP3 0.62 15.46 0.52 4.66e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.68 -12.98 -0.46 2.35e-34 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg21573476 chr21:45109991 RRP1B -0.49 -13.01 -0.46 1.65e-34 Mean corpuscular volume; BRCA cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg15145296 chr3:125709740 NA -0.54 -8.64 -0.32 4.6e-17 Blood pressure (smoking interaction); BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg09263875 chr16:632152 PIGQ 0.71 20.83 0.64 6.33e-74 Height; BRCA cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.15 -0.31 1.9e-15 Aortic root size; BRCA cis rs7572263 0.724 rs67989853 chr2:209055164 T/C cg23998903 chr2:209048830 C2orf80 -0.41 -8.37 -0.31 3.51e-16 Glioma;Non-glioblastoma glioma; BRCA trans rs11722228 0.549 rs41268389 chr4:10099277 G/A cg26043149 chr18:55253948 FECH 1.08 23.3 0.68 2.28e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg10729496 chr3:10149963 C3orf24 0.48 9.02 0.34 2.09e-18 Alzheimer's disease; BRCA cis rs1003719 0.788 rs4817844 chr21:38447064 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.6 -14.44 -0.5 4.31e-41 Eye color traits; BRCA cis rs2204008 0.702 rs8175764 chr12:38363690 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.46 0.38 9.29e-24 Bladder cancer; BRCA cis rs1113500 0.814 rs12039712 chr1:108641199 A/G cg06207961 chr1:108661230 NA 0.36 8.92 0.33 4.92e-18 Growth-regulated protein alpha levels; BRCA cis rs6964587 0.904 rs2023785 chr7:91547369 C/A cg17063962 chr7:91808500 NA -0.53 -12.19 -0.43 7.23e-31 Breast cancer; BRCA cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.5 -0.44 3.15e-32 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs7560272 0.538 rs35767294 chr2:73922834 A/G cg20560298 chr2:73613845 ALMS1 0.35 9.01 0.34 2.41e-18 Schizophrenia; BRCA cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg02221750 chr19:17393354 ANKLE1 -0.65 -12.55 -0.44 1.91e-32 Systemic lupus erythematosus; BRCA cis rs2386661 0.637 rs7099771 chr10:5654742 A/G cg17085576 chr10:5658249 NA -0.32 -7.91 -0.3 1.16e-14 Breast cancer; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.41 9.24 0.34 3.61e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3772130 0.649 rs57636696 chr3:121619464 A/T cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.2 0.34 4.82e-19 Cognitive performance; BRCA cis rs72781680 0.678 rs2551341 chr2:24014778 G/T cg08917208 chr2:24149416 ATAD2B 0.57 9.52 0.35 3.38e-20 Lymphocyte counts; BRCA cis rs9487051 0.768 rs386696 chr6:109520166 G/A cg21918786 chr6:109611834 NA -0.34 -9.15 -0.34 7.85e-19 Reticulocyte fraction of red cells; BRCA trans rs9325144 0.647 rs34963631 chr12:38912260 T/A cg23762105 chr12:34175262 ALG10 0.37 8.54 0.32 1.01e-16 Morning vs. evening chronotype; BRCA cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24110177 chr3:50126178 RBM5 -0.39 -10.68 -0.39 1.28e-24 Intelligence (multi-trait analysis); BRCA cis rs7044106 0.791 rs10985009 chr9:123493039 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.71 -15.94 -0.53 2.04e-48 Hip circumference adjusted for BMI; BRCA cis rs2243480 1.000 rs160655 chr7:65533214 T/C cg18252515 chr7:66147081 NA -0.99 -13.91 -0.48 1.31e-38 Diabetic kidney disease; BRCA cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg20701182 chr2:24300061 SF3B14 0.67 9.8 0.36 3.18e-21 Lymphocyte counts; BRCA trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg25214090 chr10:38739885 LOC399744 0.56 12.86 0.45 7.72e-34 Corneal astigmatism; BRCA cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.45 -0.32 1.92e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg26384229 chr12:38710491 ALG10B -0.58 -13.34 -0.47 5.56e-36 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10493773 0.609 rs11161664 chr1:86185379 C/T cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.34 -0.47 5.37e-36 Urate levels in overweight individuals; BRCA cis rs6543140 0.964 rs6734203 chr2:103080066 G/C cg04239558 chr2:103089729 SLC9A4 0.35 9.74 0.36 5.21e-21 Blood protein levels; BRCA cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg13770153 chr20:60521292 NA -0.44 -9.76 -0.36 4.63e-21 Body mass index; BRCA cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg07148914 chr20:33460835 GGT7 0.37 8.31 0.31 5.55e-16 Height; BRCA cis rs1904096 0.506 rs17021463 chr4:95224812 T/G cg11021082 chr4:95130006 SMARCAD1 -0.42 -9.92 -0.37 1.1e-21 Type 2 diabetes; BRCA cis rs6456156 0.586 rs6456154 chr6:167472256 C/T cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs1371614 0.632 rs6718978 chr2:27161591 G/A cg12368169 chr2:27073192 DPYSL5 0.27 7.92 0.3 1.09e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4363385 0.669 rs4845519 chr1:153003916 G/T cg25856811 chr1:152973957 SPRR3 0.3 8.23 0.31 1.05e-15 Inflammatory skin disease; BRCA cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg26116260 chr4:7069785 GRPEL1 0.95 27.93 0.74 8.26e-113 Monocyte percentage of white cells; BRCA cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg13902645 chr11:5959945 NA -0.54 -11.02 -0.4 5.67e-26 DNA methylation (variation); BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.07 0.34 1.47e-18 Tonsillectomy; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.0 -0.3 5.7e-15 Menopause (age at onset); BRCA cis rs3858526 0.635 rs2045046 chr11:5875867 A/C cg05234568 chr11:5960015 NA -0.41 -7.92 -0.3 1.07e-14 DNA methylation (variation); BRCA cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg02891314 chr5:179741120 GFPT2 0.66 13.57 0.47 4.72e-37 Height; BRCA cis rs7523273 0.606 rs2724382 chr1:207928635 G/C cg22525895 chr1:207977042 MIR29B2 0.48 12.17 0.43 8.51e-31 Schizophrenia; BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.37 8.8 0.33 1.22e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg24450063 chr1:156163899 SLC25A44 0.94 18.49 0.59 1.82e-61 Testicular germ cell tumor; BRCA cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg14847009 chr1:175162515 KIAA0040 -0.25 -9.1 -0.34 1.12e-18 Alcohol dependence; BRCA cis rs1448094 0.511 rs61930074 chr12:86218759 G/C cg19622623 chr12:86230825 RASSF9 -0.34 -9.47 -0.35 5.17e-20 Major depressive disorder; BRCA cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg14963724 chr18:72166303 CNDP2 -0.34 -9.44 -0.35 6.73e-20 Refractive error; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg16590910 chr6:42928470 GNMT 0.41 9.2 0.34 4.85e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11955398 0.529 rs62373032 chr5:59956159 G/C cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.47e-19 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs10927875 0.541 rs1739840 chr1:16342237 A/G cg06159980 chr1:16340746 HSPB7 -0.38 -8.84 -0.33 9.14e-18 Dilated cardiomyopathy; BRCA cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg11279151 chr3:101281821 RG9MTD1 -0.39 -8.81 -0.33 1.15e-17 Colorectal cancer; BRCA cis rs6450176 0.904 rs6889847 chr5:53303452 G/C ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.66 -0.53 5.04e-47 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 11.22 0.41 8.98e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10242455 0.702 rs57832867 chr7:98966396 C/T cg18809830 chr7:99032528 PTCD1 -0.65 -8.65 -0.32 4.13e-17 Blood metabolite levels; BRCA cis rs12618769 0.597 rs3754881 chr2:99132093 G/A cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.45e-16 Bipolar disorder; BRCA cis rs921968 0.541 rs636723 chr2:219373197 A/G cg10223061 chr2:219282414 VIL1 -0.27 -7.83 -0.3 2.02e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs672059 1.000 rs479994 chr1:183161729 C/T ch.1.3577855R chr1:183094577 LAMC1 0.38 8.71 0.33 2.52e-17 Hypertriglyceridemia; BRCA cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg07606381 chr6:8435919 SLC35B3 0.63 13.89 0.48 1.54e-38 Motion sickness; BRCA cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg26818010 chr10:134567672 INPP5A -0.53 -12.19 -0.43 6.88e-31 Migraine; BRCA cis rs12545109 0.800 rs1440746 chr8:57415912 G/A cg09654669 chr8:57350985 NA -0.39 -8.54 -0.32 9.82e-17 Obesity-related traits; BRCA cis rs7927592 0.913 rs11228293 chr11:68384646 T/C cg20283391 chr11:68216788 NA -0.46 -9.22 -0.34 4.1e-19 Total body bone mineral density; BRCA trans rs17685 0.753 rs10262501 chr7:75668172 G/A cg19862616 chr7:65841803 NCRNA00174 -0.82 -26.73 -0.73 3.26e-106 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs929596 0.556 rs4477910 chr2:234643737 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -9.88 -0.36 1.66e-21 Total bilirubin levels in HIV-1 infection; BRCA cis rs637571 0.522 rs550435 chr11:65732651 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.81 0.36 2.84e-21 Eosinophil percentage of white cells; BRCA cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg06046430 chr4:77819534 ANKRD56 0.61 13.63 0.47 2.57e-37 Emphysema distribution in smoking; BRCA cis rs6429082 0.905 rs12405889 chr1:235597252 A/C cg26050004 chr1:235667680 B3GALNT2 -0.35 -8.66 -0.32 3.9e-17 Adiposity; BRCA cis rs6964587 0.839 rs10808086 chr7:91447515 T/C cg17063962 chr7:91808500 NA 0.5 11.45 0.41 9.91e-28 Breast cancer; BRCA trans rs6600671 0.899 rs11249432 chr1:121283476 T/A cg17023122 chr1:144479586 NA 0.34 7.91 0.3 1.11e-14 Hip geometry; BRCA cis rs701145 0.585 rs1727923 chr3:153786303 C/T cg17054900 chr3:154042577 DHX36 -0.54 -9.14 -0.34 7.93e-19 Coronary artery disease; BRCA cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg03146154 chr1:46216737 IPP 0.46 10.17 0.37 1.24e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg13736514 chr6:26305472 NA -0.35 -11.99 -0.43 4.93e-30 Educational attainment; BRCA cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg17420585 chr12:42539391 GXYLT1 -0.39 -8.04 -0.3 4.39e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12472274 0.618 rs12477307 chr2:239110514 G/T cg17459225 chr2:239074497 NA 0.47 9.76 0.36 4.42e-21 Phospholipid levels (plasma); BRCA cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg20503657 chr10:835505 NA 0.95 14.77 0.5 1.14e-42 Eosinophil percentage of granulocytes; BRCA cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg02896835 chr1:92012615 NA -0.64 -16.63 -0.55 6.99e-52 Breast cancer; BRCA cis rs16958440 0.867 rs77149690 chr18:44697143 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.47 0.47 1.43e-36 Sitting height ratio; BRCA cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg15595755 chr5:1867978 NA 0.37 8.87 0.33 7.31e-18 Cardiovascular disease risk factors; BRCA cis rs8017423 0.934 rs2401874 chr14:90682467 C/T cg04374321 chr14:90722782 PSMC1 0.73 19.29 0.61 1.04e-65 Mortality in heart failure; BRCA cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.06 -0.34 1.53e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4930561 0.714 rs7950451 chr11:67962406 C/A cg16338278 chr11:67432957 ALDH3B2 0.44 8.97 0.33 3.37e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.19 0.31 1.46e-15 Cognitive ability; BRCA cis rs838147 0.537 rs632111 chr19:49208978 A/G cg21064579 chr19:49206444 FUT2 0.32 8.15 0.31 1.87e-15 Dietary macronutrient intake; BRCA trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg21775007 chr8:11205619 TDH -0.4 -8.17 -0.31 1.63e-15 Neuroticism; BRCA cis rs9467773 1.000 rs1884949 chr6:26568067 G/A cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.8e-21 Intelligence (multi-trait analysis); BRCA cis rs2658782 0.547 rs3133454 chr11:93059019 A/C cg15737290 chr11:93063684 CCDC67 0.6 13.95 0.48 8e-39 Pulmonary function decline; BRCA cis rs11696845 0.666 rs6073533 chr20:43361082 G/T cg25301532 chr20:43378953 KCNK15 -0.38 -9.21 -0.34 4.48e-19 Obesity-related traits; BRCA cis rs1215050 0.791 rs783959 chr4:98893476 C/T cg05340658 chr4:99064831 C4orf37 -0.45 -10.5 -0.38 6.58e-24 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9914988 0.943 rs11651867 chr17:27147248 T/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.78e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs36051895 0.603 rs10123980 chr9:5130363 T/C cg02405213 chr9:5042618 JAK2 -0.47 -8.87 -0.33 7.38e-18 Pediatric autoimmune diseases; BRCA cis rs2404602 1.000 rs4886818 chr15:76880939 G/A cg22467129 chr15:76604101 ETFA -0.39 -8.67 -0.32 3.66e-17 Blood metabolite levels; BRCA cis rs965469 0.779 rs6051717 chr20:3270242 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.81 -0.33 1.17e-17 IFN-related cytopenia; BRCA cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg11764359 chr7:65958608 NA 0.74 16.46 0.55 4.94e-51 Aortic root size; BRCA cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg06191203 chr2:152266755 RIF1 -0.36 -10.77 -0.39 5.98e-25 Lung cancer; BRCA cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.52 -0.32 1.18e-16 Monocyte percentage of white cells; BRCA trans rs877282 0.891 rs11599917 chr10:762288 G/A cg22713356 chr15:30763199 NA 1.28 24.19 0.69 2.78e-92 Uric acid levels; BRCA cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg03433033 chr1:76189801 ACADM -0.44 -8.89 -0.33 6.21e-18 Daytime sleep phenotypes; BRCA cis rs9443189 0.570 rs6903124 chr6:76290079 A/C cg01950844 chr6:76311363 SENP6 0.84 13.79 0.48 4.58e-38 Prostate cancer; BRCA cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.45e-19 Bipolar disorder; BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg08888203 chr3:10149979 C3orf24 0.65 11.89 0.43 1.4e-29 Alzheimer's disease; BRCA cis rs312274 0.632 rs10879339 chr12:41295119 T/C cg17827154 chr12:41323612 CNTN1 -0.44 -10.92 -0.4 1.46e-25 Metabolite levels (X-11787); BRCA cis rs1448094 0.512 rs7309500 chr12:86249647 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.81e-19 Major depressive disorder; BRCA cis rs12971120 0.891 rs2278158 chr18:72178300 G/T cg25817165 chr18:72167213 CNDP2 -0.72 -12.7 -0.45 4.06e-33 Refractive error; BRCA cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.84 -0.36 2.23e-21 Developmental language disorder (linguistic errors); BRCA trans rs6952808 0.689 rs1107591 chr7:2041638 G/A cg04565464 chr8:145669602 NFKBIL2 0.37 8.86 0.33 8.17e-18 Bipolar disorder and schizophrenia; BRCA cis rs826838 1.000 rs851934 chr12:39104453 G/T cg26384229 chr12:38710491 ALG10B -0.63 -16.43 -0.55 6.93e-51 Heart rate; BRCA cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg26597838 chr10:835615 NA 1.01 18.07 0.58 2.9e-59 Eosinophil percentage of granulocytes; BRCA cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg23583168 chr7:148888333 NA -0.78 -18.9 -0.6 1.28e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg09877947 chr5:131593287 PDLIM4 0.41 10.35 0.38 2.52e-23 Breast cancer; BRCA cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg26031613 chr14:104095156 KLC1 -0.45 -8.86 -0.33 7.62e-18 Schizophrenia; BRCA cis rs11792861 0.505 rs12377869 chr9:111907803 C/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.39 7.84 0.3 1.87e-14 Menarche (age at onset); BRCA cis rs7131987 0.903 rs11050161 chr12:29420049 A/G cg09582351 chr12:29534625 ERGIC2 -0.48 -11.73 -0.42 6.3e-29 QT interval; BRCA cis rs12579753 1.000 rs12367791 chr12:82237278 C/T cg07988820 chr12:82153109 PPFIA2 -0.64 -10.39 -0.38 1.87e-23 Resting heart rate; BRCA cis rs1506636 0.927 rs6959270 chr7:123310628 G/A cg03229431 chr7:123269106 ASB15 -0.63 -14.15 -0.49 9.48e-40 Plateletcrit;Platelet count; BRCA cis rs3806843 0.931 rs13168670 chr5:140146899 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.44 -10.36 -0.38 2.4e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs1348850 0.914 rs4893823 chr2:178285811 C/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.45 -9.21 -0.34 4.6e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10927875 0.541 rs1739840 chr1:16342237 A/G cg22431228 chr1:16359049 CLCNKA -0.43 -9.71 -0.36 6.72e-21 Dilated cardiomyopathy; BRCA cis rs7264396 0.887 rs224419 chr20:34143092 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.47 -10.02 -0.37 4.91e-22 Total cholesterol levels; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg22764044 chr5:178986830 RUFY1 0.39 10.17 0.37 1.24e-22 Lung cancer; BRCA cis rs10911232 0.507 rs61081633 chr1:182995608 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs7246657 0.598 rs10405372 chr19:37668775 A/C cg23950597 chr19:37808831 NA -0.66 -10.28 -0.38 4.82e-23 Coronary artery calcification; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg07691484 chr11:842764 TSPAN4;POLR2L -0.68 -16.13 -0.54 2.43e-49 Mean platelet volume; BRCA cis rs586533 0.846 rs636073 chr11:99495789 C/T cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg22920501 chr2:26401640 FAM59B 0.9 16.28 0.54 3.94e-50 Gut microbiome composition (summer); BRCA cis rs796364 0.951 rs12620298 chr2:201047184 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.48 -8.21 -0.31 1.19e-15 Schizophrenia; BRCA cis rs12541635 0.677 rs1496180 chr8:106973877 T/G cg10147462 chr8:107024639 NA 0.39 10.49 0.38 7.38e-24 Age of smoking initiation; BRCA trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg25482853 chr8:67687455 SGK3 1.02 16.08 0.54 4.27e-49 Lung disease severity in cystic fibrosis; BRCA trans rs4650994 1.000 rs17361251 chr1:178520577 C/A cg05059571 chr16:84539110 KIAA1609 -0.42 -9.64 -0.36 1.22e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg02951883 chr7:2050386 MAD1L1 -0.5 -10.86 -0.39 2.54e-25 Bipolar disorder and schizophrenia; BRCA cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg13010199 chr12:38710504 ALG10B 0.39 8.89 0.33 6.14e-18 Morning vs. evening chronotype; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg15242686 chr22:24348715 GSTTP1 0.33 8.19 0.31 1.46e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs933688 1.000 rs11959525 chr5:90703840 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.46 0.61 1.35e-66 Smoking behavior; BRCA cis rs9790314 1.000 rs336585 chr3:161081670 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.35 -0.49 1.14e-40 Morning vs. evening chronotype; BRCA cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg26597838 chr10:835615 NA 0.85 15.48 0.52 3.68e-46 Eosinophil percentage of granulocytes; BRCA trans rs9291683 0.588 rs4697705 chr4:10108127 G/A cg26043149 chr18:55253948 FECH -0.39 -8.5 -0.32 1.29e-16 Bone mineral density; BRCA cis rs1577917 1.000 rs7760207 chr6:86721700 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.5 -0.44 3.27e-32 Response to antipsychotic treatment; BRCA cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg16482183 chr6:26056742 HIST1H1C 0.5 10.51 0.38 6.27e-24 Height; BRCA cis rs9815354 0.767 rs6805140 chr3:41995791 A/G cg03022575 chr3:42003672 ULK4 0.62 9.06 0.34 1.62e-18 Pulse pressure;Diastolic blood pressure; BRCA cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg18876405 chr7:65276391 NA -0.51 -11.62 -0.42 1.94e-28 Aortic root size; BRCA cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg04450456 chr4:17643702 FAM184B 0.38 10.42 0.38 1.35e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg11279151 chr3:101281821 RG9MTD1 -0.34 -7.89 -0.3 1.29e-14 Colorectal cancer; BRCA cis rs875971 0.660 rs801217 chr7:66010577 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.07 -0.3 3.56e-15 Aortic root size; BRCA cis rs10740039 0.804 rs894384 chr10:62452293 C/G cg02922035 chr10:62493342 NA 0.42 8.01 0.3 5.4e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs8114671 0.967 rs2069945 chr20:33761837 C/G cg24642439 chr20:33292090 TP53INP2 0.42 8.64 0.32 4.52e-17 Height; BRCA cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg11764359 chr7:65958608 NA -0.75 -16.59 -0.55 1.12e-51 Aortic root size; BRCA cis rs9814567 0.806 rs4955525 chr3:134317008 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.88 -0.56 3.92e-53 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs672059 1.000 rs674343 chr1:183162052 G/A ch.1.3577855R chr1:183094577 LAMC1 0.38 8.71 0.33 2.56e-17 Hypertriglyceridemia; BRCA cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg10523679 chr1:76189770 ACADM 0.71 12.78 0.45 1.85e-33 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg21609526 chr1:3105151 PRDM16 -0.38 -8.93 -0.33 4.57e-18 Migraine; BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.99 18.6 0.59 4.85e-62 Platelet count; BRCA cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg13010199 chr12:38710504 ALG10B 0.45 9.42 0.35 8.38e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.95 -20.85 -0.64 4.98e-74 Gut microbiome composition (summer); BRCA cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -12.03 -0.43 3.44e-30 Bipolar disorder; BRCA cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 9.04 0.34 1.89e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs7917772 0.560 rs4919664 chr10:104363408 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.32 0.49 1.48e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.86 0.45 7.85e-34 Bipolar disorder; BRCA cis rs9815354 0.812 rs73071208 chr3:41978738 A/T cg03022575 chr3:42003672 ULK4 0.7 9.69 0.36 8.3e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs11190604 0.767 rs10883483 chr10:102174244 T/C cg07080220 chr10:102295463 HIF1AN 0.49 10.12 0.37 2.03e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7246657 0.722 rs6508736 chr19:38061757 A/G cg23950597 chr19:37808831 NA -0.5 -8.62 -0.32 5.36e-17 Coronary artery calcification; BRCA cis rs7561273 0.609 rs2080727 chr2:24350907 A/G cg04809136 chr2:24300158 SF3B14 -0.4 -8.84 -0.33 9.44e-18 Quantitative traits; BRCA cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg18132916 chr6:79620363 NA -0.47 -10.74 -0.39 7.41e-25 Intelligence (multi-trait analysis); BRCA cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg22307297 chr20:60903441 LAMA5 0.34 8.58 0.32 7.39e-17 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs4988958 0.565 rs1420100 chr2:103037002 C/A cg03938978 chr2:103052716 IL18RAP 0.29 8.35 0.31 4.32e-16 Asthma (childhood onset); BRCA cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.37 0.31 3.68e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs60843830 0.928 rs2306060 chr2:230912 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.69 14.31 0.49 1.72e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg15112475 chr7:1198522 ZFAND2A -0.43 -8.27 -0.31 7.67e-16 Bronchopulmonary dysplasia; BRCA cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg26818010 chr10:134567672 INPP5A -0.36 -8.62 -0.32 5.07e-17 Migraine; BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg05279229 chr7:1896384 MAD1L1 -0.4 -7.95 -0.3 8.37e-15 Bipolar disorder and schizophrenia; BRCA trans rs526821 0.595 rs551665 chr11:55343268 G/A cg11707556 chr5:10655725 ANKRD33B -0.37 -8.21 -0.31 1.19e-15 Pediatric bone mineral density (spine); BRCA cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg04025307 chr7:1156635 C7orf50 0.37 8.45 0.32 2.02e-16 Longevity;Endometriosis; BRCA cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg24531977 chr5:56204891 C5orf35 -0.86 -17.89 -0.58 2.57e-58 Initial pursuit acceleration; BRCA cis rs7020830 0.867 rs13301916 chr9:37361455 A/C cg14294708 chr9:37120828 ZCCHC7 1.07 32.46 0.79 2.77e-137 Schizophrenia; BRCA cis rs2072499 0.750 rs2241109 chr1:156173082 C/T cg25208724 chr1:156163844 SLC25A44 0.87 17.55 0.57 1.46e-56 Testicular germ cell tumor; BRCA cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.5 -0.44 2.98e-32 Bipolar disorder; BRCA cis rs4664304 0.620 rs2136977 chr2:160722850 C/T cg01092293 chr2:160761427 LY75 0.35 8.45 0.32 1.91e-16 Crohn's disease;Inflammatory bowel disease; BRCA trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg15704280 chr7:45808275 SEPT13 -0.57 -9.65 -0.36 1.14e-20 Axial length; BRCA cis rs1018836 0.923 rs2105967 chr8:91587522 A/G cg16814680 chr8:91681699 NA -0.59 -12.52 -0.44 2.63e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs7301826 0.651 rs6486601 chr12:131301237 A/T cg11011512 chr12:131303247 STX2 -0.44 -11.11 -0.4 2.5e-26 Plasma plasminogen activator levels; BRCA cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg11764359 chr7:65958608 NA 0.79 19.25 0.61 1.83e-65 Aortic root size; BRCA cis rs16910800 0.689 rs56101126 chr11:23188861 T/A cg20040320 chr11:23191996 NA -0.59 -10.23 -0.38 7.61e-23 Cancer; BRCA trans rs2204008 0.776 rs8186824 chr12:38316537 A/C cg06521331 chr12:34319734 NA -0.49 -9.74 -0.36 5.28e-21 Bladder cancer; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.81 -14.32 -0.49 1.58e-40 Gut microbiome composition (summer); BRCA cis rs6977940 0.512 rs11765726 chr7:2850878 A/G cg19731401 chr7:2775893 GNA12 0.48 7.96 0.3 7.68e-15 White matter integrity; BRCA cis rs68170813 0.559 rs77829121 chr7:106968470 A/G cg02696742 chr7:106810147 HBP1 -0.54 -8.87 -0.33 7.01e-18 Coronary artery disease; BRCA cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg19077165 chr18:44547161 KATNAL2 -0.58 -12.99 -0.46 2.16e-34 Personality dimensions; BRCA cis rs881375 0.933 rs7859805 chr9:123664123 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.53 0.32 1.09e-16 Rheumatoid arthritis; BRCA cis rs698833 0.501 rs12473699 chr2:44507673 G/A cg04920474 chr2:44395004 PPM1B 0.39 9.16 0.34 7.2e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs3812049 0.826 rs2409110 chr5:127433047 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.59 10.78 0.39 5.33e-25 Lymphocyte counts;Red cell distribution width; BRCA cis rs4787491 0.704 rs35605010 chr16:30033428 A/G cg06326092 chr16:30034487 C16orf92 0.37 9.48 0.35 4.76e-20 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1801251 0.963 rs6739638 chr2:233576015 G/A cg08000102 chr2:233561755 GIGYF2 0.62 13.46 0.47 1.49e-36 Coronary artery disease; BRCA cis rs67460515 0.563 rs13256 chr3:160796505 G/A cg03342759 chr3:160939853 NMD3 -0.67 -13.16 -0.46 3.56e-35 Parkinson's disease; BRCA cis rs1691799 0.899 rs1168299 chr12:66736074 C/G cg16791601 chr12:66731901 HELB -0.69 -19.26 -0.61 1.56e-65 White blood cell count (basophil); BRCA cis rs4363385 0.747 rs11205149 chr1:152958840 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.69 -0.32 3.15e-17 Inflammatory skin disease; BRCA trans rs35110281 0.748 rs2838324 chr21:44999820 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.01 0.37 5.06e-22 Mean corpuscular volume; BRCA cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg24558204 chr6:135376177 HBS1L 0.6 16.25 0.54 5.98e-50 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs6066835 1.000 rs6063314 chr20:47353106 T/C cg18078177 chr20:47281410 PREX1 0.69 8.6 0.32 6.2e-17 Multiple myeloma; BRCA cis rs11112613 0.762 rs17037312 chr12:105950085 C/T cg03607813 chr12:105948248 NA 0.6 11.16 0.4 1.57e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA trans rs208520 0.526 rs2881644 chr6:66803535 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.12 37.73 0.83 9.26e-165 Exhaled nitric oxide output; BRCA cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg18132916 chr6:79620363 NA -0.38 -7.82 -0.3 2.2e-14 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.587 rs1466741 chr3:47247214 C/T cg27129171 chr3:47204927 SETD2 -0.71 -17.23 -0.56 6.2e-55 Colorectal cancer; BRCA cis rs10911232 0.507 rs10911231 chr1:183051745 T/A ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.71e-54 Hypertriglyceridemia; BRCA cis rs12971120 0.891 rs71359051 chr18:72169723 G/A cg26446133 chr18:72167187 CNDP2 -0.75 -14.47 -0.5 2.9e-41 Refractive error; BRCA cis rs829883 0.659 rs11109524 chr12:98939172 G/A cg25150519 chr12:98850993 NA -0.5 -9.04 -0.34 1.91e-18 Colorectal adenoma (advanced); BRCA cis rs10089 1.000 rs7703634 chr5:127509223 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 12.89 0.45 5.95e-34 Ileal carcinoids; BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg16606324 chr3:10149918 C3orf24 0.45 8.07 0.3 3.62e-15 Alzheimer's disease; BRCA cis rs6546550 0.901 rs4144081 chr2:70155482 G/A cg02498382 chr2:70120550 SNRNP27 -0.53 -11.43 -0.41 1.2e-27 Prevalent atrial fibrillation; BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg21782813 chr7:2030301 MAD1L1 0.4 10.63 0.39 2.08e-24 Bipolar disorder and schizophrenia; BRCA cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg12373951 chr3:133503437 NA -0.43 -10.37 -0.38 2.12e-23 Iron status biomarkers; BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.36 -7.86 -0.3 1.67e-14 Tonsillectomy; BRCA cis rs9341808 0.727 rs9361599 chr6:81025242 C/G cg08355045 chr6:80787529 NA 0.35 9.23 0.34 3.85e-19 Sitting height ratio; BRCA cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.27 -0.41 5.59e-27 Schizophrenia; BRCA cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg09035930 chr12:129282057 SLC15A4 0.49 13.82 0.48 3.51e-38 Systemic lupus erythematosus; BRCA cis rs1878931 0.501 rs9921169 chr16:3421261 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.58 11.75 0.42 5.34e-29 Body mass index (adult); BRCA cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.48 -9.34 -0.35 1.55e-19 Chronic sinus infection; BRCA cis rs4363385 0.720 rs1970328 chr1:152975829 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.49 0.41 6.87e-28 Monocyte percentage of white cells; BRCA trans rs61931739 0.857 rs1828514 chr12:34139600 A/G cg26384229 chr12:38710491 ALG10B 0.44 10.57 0.39 3.4e-24 Morning vs. evening chronotype; BRCA cis rs7809950 0.678 rs62482499 chr7:106975059 C/G cg23024343 chr7:107201750 COG5 -0.43 -9.42 -0.35 8.36e-20 Coronary artery disease; BRCA cis rs67981189 0.865 rs2526876 chr14:71378188 T/C cg15816911 chr14:71606274 NA -0.37 -8.23 -0.31 1.09e-15 Schizophrenia; BRCA cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.84e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8054556 0.647 rs4788211 chr16:30015565 C/T cg06326092 chr16:30034487 C16orf92 0.35 8.82 0.33 1.06e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg08917208 chr2:24149416 ATAD2B 0.93 13.87 0.48 1.91e-38 Lymphocyte counts; BRCA cis rs6977660 0.714 rs17141884 chr7:19790280 A/G cg05791153 chr7:19748676 TWISTNB -0.57 -10.34 -0.38 2.73e-23 Thyroid stimulating hormone; BRCA cis rs1568889 0.838 rs7127069 chr11:28325412 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 19.84 0.62 1.36e-68 Bipolar disorder; BRCA cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg13319975 chr6:146136371 FBXO30 0.41 9.22 0.34 4.41e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg11764359 chr7:65958608 NA -0.62 -13.63 -0.47 2.45e-37 Calcium levels; BRCA cis rs6032067 0.598 rs2741500 chr20:43944958 G/T cg20256260 chr20:43936981 MATN4;RBPJL 0.34 8.08 0.3 3.31e-15 Blood protein levels; BRCA cis rs10540 1.000 rs61876335 chr11:488878 T/C cg19913688 chr11:428466 ANO9 -0.65 -9.69 -0.36 7.98e-21 Body mass index; BRCA cis rs11098499 0.754 rs2036856 chr4:120249288 G/A cg09307838 chr4:120376055 NA 0.64 14.0 0.48 5.12e-39 Corneal astigmatism; BRCA cis rs4908768 0.501 rs1463050 chr1:8597042 G/A cg20416874 chr1:8611966 RERE -0.29 -8.35 -0.31 4.23e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs78456975 1.000 rs7584264 chr2:1565555 A/G cg26248373 chr2:1572462 NA -0.45 -9.03 -0.34 2.01e-18 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg02018176 chr4:1364513 KIAA1530 0.39 8.13 0.31 2.22e-15 Longevity; BRCA cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg24060327 chr5:131705240 SLC22A5 0.61 11.35 0.41 2.4200000000000002e-27 Breast cancer; BRCA cis rs67460515 0.926 rs11715591 chr3:161043137 C/T cg03342759 chr3:160939853 NMD3 -0.81 -18.13 -0.58 1.44e-59 Parkinson's disease; BRCA cis rs7737355 0.947 rs2191001 chr5:131096677 C/G cg06307176 chr5:131281290 NA 0.53 10.2 0.37 9.89e-23 Life satisfaction; BRCA cis rs654950 0.806 rs10749832 chr1:42041806 C/T cg06885757 chr1:42089581 HIVEP3 0.3 10.25 0.38 6.54e-23 Airway imaging phenotypes; BRCA cis rs6005807 0.719 rs9625523 chr22:29045745 T/C cg12565055 chr22:29076175 TTC28 0.49 9.28 0.34 2.68e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg09184832 chr6:79620586 NA -0.53 -11.56 -0.42 3.34e-28 Intelligence (multi-trait analysis); BRCA cis rs28830936 1.000 rs11629485 chr15:41904569 C/T cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.13 -0.34 9.23e-19 Diastolic blood pressure; BRCA cis rs1829883 1.000 rs1829883 chr5:98781103 C/T cg08333243 chr5:99726346 NA -0.37 -8.96 -0.33 3.5e-18 Hemostatic factors and hematological phenotypes; BRCA cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg09537434 chr19:41945824 ATP5SL -0.62 -12.85 -0.45 9.12e-34 Migraine;Coronary artery disease; BRCA cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.58 -12.75 -0.45 2.47e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs427394 0.802 rs274718 chr5:6720988 G/T cg10857441 chr5:6722123 POLS -0.33 -11.06 -0.4 3.92e-26 Menopause (age at onset); BRCA cis rs1865721 0.771 rs724764 chr18:73139742 C/T cg26385618 chr18:73139727 C18orf62 -0.43 -10.63 -0.39 2.03e-24 Intelligence; BRCA cis rs2479724 0.901 rs2185798 chr6:41773576 G/C cg17623882 chr6:41773611 USP49 0.38 10.31 0.38 3.59e-23 Menarche (age at onset); BRCA cis rs6840360 0.571 rs11932059 chr4:152524496 G/A cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 6.04e-15 Intelligence (multi-trait analysis); BRCA cis rs6733011 0.578 rs10181972 chr2:99497284 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.43 -0.32 2.29e-16 Bipolar disorder; BRCA cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg14993813 chr1:46806288 NSUN4 -0.47 -9.07 -0.34 1.48e-18 Menopause (age at onset); BRCA cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg27129171 chr3:47204927 SETD2 0.71 16.89 0.56 3.29e-53 Colorectal cancer; BRCA trans rs11098499 0.542 rs10440343 chr4:120309787 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.77 -0.45 2.03e-33 Lymphocyte counts; BRCA cis rs4631830 0.720 rs4935573 chr10:51504385 A/G cg20129853 chr10:51489980 NA 0.3 8.26 0.31 8.09e-16 Prostate-specific antigen levels; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg05552183 chr6:42928497 GNMT 0.7 15.76 0.53 1.61e-47 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs3733585 0.682 rs13124563 chr4:9927553 A/G cg26043149 chr18:55253948 FECH 0.4 8.85 0.33 8.23e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg01119278 chr6:110721349 DDO -0.43 -10.54 -0.38 4.72e-24 Platelet distribution width; BRCA trans rs61931739 0.500 rs7309421 chr12:34553795 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.84 0.36 2.19e-21 Morning vs. evening chronotype; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg27170947 chr2:26402098 FAM59B -0.72 -13.08 -0.46 8.28e-35 Gut microbiome composition (summer); BRCA cis rs709400 0.628 rs12889639 chr14:103860206 G/A cg12935359 chr14:103987150 CKB 0.58 14.23 0.49 4.1e-40 Body mass index; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.73 15.93 0.53 2.46e-48 Lymphocyte counts; BRCA cis rs9549260 0.709 rs4943795 chr13:41173433 C/T cg21288729 chr13:41239152 FOXO1 -0.6 -12.35 -0.44 1.42e-31 Red blood cell count; BRCA trans rs1994135 0.654 rs11052759 chr12:33724126 G/A cg13010199 chr12:38710504 ALG10B 0.42 7.92 0.3 1.05e-14 Resting heart rate; BRCA cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg15017067 chr4:17643749 FAM184B -0.28 -8.59 -0.32 6.59e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9811920 0.660 rs7619512 chr3:99729132 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -10.45 -0.38 1.08e-23 Axial length; BRCA trans rs7824557 0.767 rs7837036 chr8:11175489 A/G cg15556689 chr8:8085844 FLJ10661 0.4 9.3 0.35 2.2e-19 Retinal vascular caliber; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg20219911 chr3:52813652 ITIH1 0.29 8.05 0.3 3.93e-15 Bipolar disorder; BRCA cis rs8114671 0.562 rs1060615 chr20:33478381 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -8.89 -0.33 6.41e-18 Height; BRCA cis rs3820928 0.605 rs7560867 chr2:227780945 C/A cg11843606 chr2:227700838 RHBDD1 -0.5 -11.61 -0.42 2.01e-28 Pulmonary function; BRCA cis rs4965272 1.000 rs4965273 chr15:100584818 C/T cg27344315 chr15:100560801 ADAMTS17 0.38 8.51 0.32 1.25e-16 Gastroesophageal reflux disease; BRCA cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg03388025 chr16:89894329 SPIRE2 0.29 9.12 0.34 9.29e-19 Vitiligo; BRCA cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg05279229 chr7:1896384 MAD1L1 -0.4 -7.87 -0.3 1.47e-14 Bipolar disorder and schizophrenia; BRCA cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg26408565 chr15:76604113 ETFA -0.48 -10.08 -0.37 2.78e-22 Blood metabolite levels; BRCA cis rs2274273 1.000 rs61508494 chr14:55587297 T/C cg04306507 chr14:55594613 LGALS3 0.32 9.0 0.34 2.52e-18 Protein biomarker; BRCA cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg17971929 chr21:40555470 PSMG1 0.6 13.74 0.48 7.58e-38 Cognitive function; BRCA cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg17644776 chr2:200775616 C2orf69 -0.42 -8.6 -0.32 6.19e-17 Osteoporosis; BRCA cis rs2762353 0.845 rs35720558 chr6:25784800 A/C cg03264133 chr6:25882463 NA 0.5 11.23 0.41 7.65e-27 Blood metabolite levels; BRCA cis rs36051895 0.589 rs6476947 chr9:5204279 A/G cg02405213 chr9:5042618 JAK2 -0.44 -8.26 -0.31 8.59e-16 Pediatric autoimmune diseases; BRCA cis rs11252926 0.523 rs816596 chr10:548004 C/T cg18196295 chr10:418757 DIP2C 0.45 10.13 0.37 1.77e-22 Psychosis in Alzheimer's disease; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg26597838 chr10:835615 NA 0.97 14.93 0.51 1.76e-43 Eosinophil percentage of granulocytes; BRCA cis rs6964587 0.626 rs2106745 chr7:91506635 C/T cg17063962 chr7:91808500 NA -0.55 -12.71 -0.45 3.57e-33 Breast cancer; BRCA cis rs11098499 0.909 rs35111518 chr4:120440682 A/G cg09307838 chr4:120376055 NA 0.69 14.05 0.49 2.92e-39 Corneal astigmatism; BRCA cis rs9400271 0.632 rs34981677 chr6:109590920 T/C cg21918786 chr6:109611834 NA -0.32 -8.05 -0.3 4.14e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs6089584 0.507 rs6061999 chr20:60637429 G/A cg06108461 chr20:60628389 TAF4 -0.7 -14.5 -0.5 2.21e-41 Body mass index; BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.73 0.57 1.64e-57 Platelet count; BRCA cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg25319279 chr11:5960081 NA -0.4 -7.92 -0.3 1.03e-14 DNA methylation (variation); BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -9.41 -0.35 8.94e-20 Bipolar disorder and schizophrenia; BRCA trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -10.87 -0.4 2.22e-25 Retinal vascular caliber; BRCA cis rs17001868 0.568 rs12484697 chr22:40736472 A/G cg07138101 chr22:40742427 ADSL -0.57 -10.59 -0.39 3.02e-24 Mammographic density (dense area); BRCA cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg21918786 chr6:109611834 NA -0.34 -9.11 -0.34 1.09e-18 Reticulocyte fraction of red cells; BRCA cis rs2769264 1.000 rs6684085 chr1:151357333 C/T cg18801370 chr1:151430492 POGZ -0.52 -12.26 -0.44 3.45e-31 Blood trace element (Cu levels); BRCA cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.31 0.49 1.72e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg14829155 chr15:31115871 NA -0.43 -10.14 -0.37 1.74e-22 Huntington's disease progression; BRCA cis rs17092148 0.597 rs57495888 chr20:33092724 T/C cg16810054 chr20:33298113 TP53INP2 0.43 9.41 0.35 8.59e-20 Neuroticism; BRCA cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 4.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3820928 0.874 rs10183633 chr2:227887828 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.44e-16 Pulmonary function; BRCA cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg21427119 chr20:30132790 HM13 -0.41 -8.64 -0.32 4.67e-17 Mean corpuscular hemoglobin; BRCA cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.43 -0.44 6.18e-32 Developmental language disorder (linguistic errors); BRCA cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg10978503 chr1:24200527 CNR2 0.47 12.59 0.45 1.23e-32 Immature fraction of reticulocytes; BRCA cis rs7178424 0.742 rs12906423 chr15:62203884 T/A cg00456672 chr15:62358751 C2CD4A -0.38 -9.29 -0.34 2.43e-19 Height; BRCA cis rs9818758 0.607 rs9311439 chr3:49310408 A/G cg00383909 chr3:49044727 WDR6 0.74 12.69 0.45 4.57e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg26446133 chr18:72167187 CNDP2 -0.75 -14.8 -0.51 7.75e-43 Refractive error; BRCA cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg09184832 chr6:79620586 NA -0.52 -11.63 -0.42 1.64e-28 Intelligence (multi-trait analysis); BRCA cis rs1595825 0.891 rs73054827 chr2:198649905 G/A cg19156104 chr2:198669113 PLCL1 -0.42 -8.01 -0.3 5.33e-15 Ulcerative colitis; BRCA cis rs7945718 0.967 rs10831904 chr11:12760937 A/G cg25843174 chr11:12811716 TEAD1 0.23 8.8 0.33 1.25e-17 Educational attainment (years of education); BRCA cis rs9467773 0.935 rs9461270 chr6:26544110 A/G cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.686 rs4896833 chr6:145965673 T/G cg23711669 chr6:146136114 FBXO30 0.7 16.7 0.55 3.23e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs11718455 0.767 rs6782500 chr3:43990260 A/G cg08738300 chr3:44038990 NA -0.47 -8.8 -0.33 1.22e-17 Coronary artery disease; BRCA cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg24006582 chr15:45444508 DUOX1 0.54 10.51 0.38 6.04e-24 Uric acid levels; BRCA cis rs12617721 0.756 rs3754889 chr2:99088633 T/G cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg14530993 chr4:882597 GAK 0.59 9.54 0.35 2.98e-20 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg26314531 chr2:26401878 FAM59B -0.66 -11.25 -0.41 6.63e-27 Gut microbiome composition (summer); BRCA cis rs7945705 0.776 rs11042069 chr11:8817315 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.5 10.39 0.38 1.84e-23 Hemoglobin concentration; BRCA cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg20701182 chr2:24300061 SF3B14 0.65 9.37 0.35 1.2e-19 Lymphocyte counts; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg10150615 chr22:24372951 LOC391322 0.47 10.46 0.38 9.73e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs733592 0.965 rs1978161 chr12:48467721 A/G cg24011408 chr12:48396354 COL2A1 -0.46 -9.79 -0.36 3.39e-21 Plateletcrit; BRCA cis rs11249608 0.789 rs903989 chr5:178434434 C/T cg21905437 chr5:178450457 ZNF879 0.48 9.75 0.36 4.85e-21 Pubertal anthropometrics; BRCA trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.22 -19.87 -0.62 8.44e-69 Hemostatic factors and hematological phenotypes; BRCA cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.45 0.38 1.08e-23 Motion sickness; BRCA trans rs6582630 0.519 rs8186992 chr12:38325848 C/T cg06521331 chr12:34319734 NA -0.45 -8.49 -0.32 1.5e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.01 0.34 2.27e-18 Motion sickness; BRCA trans rs9291683 0.618 rs13137343 chr4:10043028 C/A cg26043149 chr18:55253948 FECH 0.43 9.22 0.34 4.29e-19 Bone mineral density; BRCA cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.5 0.44 3.09e-32 Electroencephalogram traits; BRCA cis rs1707322 1.000 rs785469 chr1:46521091 C/T cg03146154 chr1:46216737 IPP -0.44 -9.85 -0.36 2.04e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3806843 0.966 rs2563267 chr5:140136913 C/T cg16179182 chr5:140090404 VTRNA1-1 0.43 10.12 0.37 2.05e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs9325144 0.510 rs7952795 chr12:38720686 C/T cg26384229 chr12:38710491 ALG10B 0.51 12.79 0.45 1.61e-33 Morning vs. evening chronotype; BRCA cis rs1691799 0.867 rs1168347 chr12:66757303 T/C cg16791601 chr12:66731901 HELB -0.6 -16.06 -0.54 4.96e-49 White blood cell count (basophil); BRCA cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs7131987 0.903 rs10843373 chr12:29420608 A/T cg09582351 chr12:29534625 ERGIC2 -0.39 -9.35 -0.35 1.48e-19 QT interval; BRCA cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg12386194 chr3:101231763 SENP7 -0.6 -12.38 -0.44 1.09e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.69 0.33 3.02e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.08 0.4 3.31e-26 Bipolar disorder; BRCA cis rs7927771 0.864 rs3781626 chr11:47442893 A/T cg20307385 chr11:47447363 PSMC3 -0.4 -8.92 -0.33 4.96e-18 Subjective well-being; BRCA cis rs1577917 0.739 rs9450318 chr6:86427177 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.33 9.11 0.34 1.01e-18 Response to antipsychotic treatment; BRCA cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg00071950 chr4:10020882 SLC2A9 0.43 10.01 0.37 5.27e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17401966 0.867 rs61775872 chr1:10279308 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.75 0.48 7.09e-38 Hepatocellular carcinoma; BRCA cis rs826838 0.559 rs1843891 chr12:38617018 T/C cg26384229 chr12:38710491 ALG10B 0.43 10.32 0.38 3.28e-23 Heart rate; BRCA cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg18225595 chr11:63971243 STIP1 0.39 9.68 0.36 8.78e-21 Platelet count; BRCA cis rs2637266 0.935 rs7918777 chr10:78394375 A/G cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg17366294 chr4:99064904 C4orf37 0.43 10.02 0.37 4.91e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs17685 0.753 rs4728550 chr7:75670988 C/A cg16489192 chr7:75678113 MDH2;STYXL1 0.4 8.97 0.33 3.13e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg02659138 chr7:134003124 SLC35B4 0.34 10.69 0.39 1.14e-24 Mean platelet volume; BRCA cis rs5758659 0.652 rs133327 chr22:42407689 T/C cg15557168 chr22:42548783 NA -0.31 -8.64 -0.32 4.39e-17 Cognitive function; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg21782813 chr7:2030301 MAD1L1 0.43 12.37 0.44 1.11e-31 Bipolar disorder and schizophrenia; BRCA cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 11.95 0.43 7.58e-30 Personality dimensions; BRCA cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg15485101 chr11:133734466 NA 0.39 9.42 0.35 8.19e-20 Childhood ear infection; BRCA cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg11266682 chr4:10021025 SLC2A9 -0.41 -10.96 -0.4 1.03e-25 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs208520 0.706 rs851601 chr6:66893853 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.92 -17.6 -0.57 7.86e-57 Exhaled nitric oxide output; BRCA cis rs1395 0.744 rs11126932 chr2:27476282 G/A cg23587288 chr2:27483067 SLC30A3 -0.38 -8.9 -0.33 5.91e-18 Blood metabolite levels; BRCA cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg21573476 chr21:45109991 RRP1B -0.32 -7.99 -0.3 6.09e-15 Mean corpuscular volume; BRCA cis rs9858542 1.000 rs4283605 chr3:49678651 A/G cg03060546 chr3:49711283 APEH -0.61 -12.3 -0.44 2.28e-31 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -9.68 -0.36 9.05e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7246657 0.765 rs10402455 chr19:37728707 G/A cg18154014 chr19:37997991 ZNF793 0.6 10.34 0.38 2.87e-23 Coronary artery calcification; BRCA cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg21385522 chr1:16154831 NA 0.46 9.97 0.37 7.08e-22 Systolic blood pressure; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg05863683 chr7:1912471 MAD1L1 0.38 7.82 0.3 2.21e-14 Bipolar disorder and schizophrenia; BRCA cis rs6973256 0.897 rs17659708 chr7:133355098 A/G cg07491979 chr7:133331646 EXOC4 -0.4 -9.21 -0.34 4.77e-19 Intelligence (multi-trait analysis); BRCA trans rs783540 0.934 rs4779053 chr15:83371598 T/C cg18393722 chr15:85113863 UBE2QP1 0.27 8.19 0.31 1.4e-15 Schizophrenia; BRCA cis rs3806843 0.771 rs801174 chr5:140112712 C/T cg16179182 chr5:140090404 VTRNA1-1 0.45 10.44 0.38 1.14e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs17376456 0.877 rs10476596 chr5:93367074 C/T cg25358565 chr5:93447407 FAM172A -1.21 -18.19 -0.58 6.75e-60 Diabetic retinopathy; BRCA cis rs4409675 0.576 rs1474908 chr1:28213213 C/T cg23691781 chr1:28212827 C1orf38 -0.31 -9.96 -0.37 7.97e-22 Corneal astigmatism; BRCA cis rs79518236 1 rs79518236 chr7:98026554 ACT/A cg09267113 chr7:98030324 BAIAP2L1 -0.59 -15.82 -0.53 7.81e-48 Breast cancer; BRCA cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg11812906 chr14:75593930 NEK9 -0.68 -15.59 -0.52 1.17e-46 Height; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00166722 chr3:10149974 C3orf24 -0.66 -13.15 -0.46 4.12e-35 Alzheimer's disease; BRCA cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg22535103 chr8:58192502 C8orf71 -0.57 -12.38 -0.44 1.01e-31 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.615 rs28850368 chr4:120554313 G/A cg25214090 chr10:38739885 LOC399744 0.44 10.01 0.37 5.38e-22 Corneal astigmatism; BRCA cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA trans rs8062405 1.000 rs12443881 chr16:28841777 C/T cg09719594 chr16:21412588 NA -0.35 -7.99 -0.3 6.09e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg06634786 chr22:41940651 POLR3H -0.45 -8.52 -0.32 1.11e-16 Vitiligo; BRCA cis rs2806561 0.929 rs6694445 chr1:23540428 A/G cg12483005 chr1:23474871 LUZP1 0.38 8.34 0.31 4.51e-16 Height; BRCA trans rs7647973 0.626 rs7637711 chr3:49829653 A/G cg21659725 chr3:3221576 CRBN 0.48 9.13 0.34 9.02e-19 Menarche (age at onset); BRCA cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg21427119 chr20:30132790 HM13 -0.42 -8.92 -0.33 4.92e-18 Mean corpuscular hemoglobin; BRCA cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg08975724 chr8:8085496 FLJ10661 -0.4 -8.69 -0.33 3.08e-17 Mood instability; BRCA cis rs74181299 0.684 rs6713746 chr2:65324492 G/C cg05010058 chr2:65284262 CEP68 -0.29 -7.86 -0.3 1.61e-14 Pulse pressure; BRCA cis rs4713118 0.869 rs4713121 chr6:27722064 T/C cg20933634 chr6:27740509 NA 0.46 9.05 0.34 1.71e-18 Parkinson's disease; BRCA cis rs28374715 0.532 rs316604 chr15:41775221 C/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -27.14 -0.73 1.75e-108 Ulcerative colitis; BRCA cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.35e-15 Extrinsic epigenetic age acceleration; BRCA cis rs2742234 0.590 rs2435339 chr10:43642173 G/C cg15436174 chr10:43711423 RASGEF1A -0.54 -10.96 -0.4 1.02e-25 Hirschsprung disease; BRCA cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.37 -0.41 1.99e-27 Schizophrenia; BRCA trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg15556689 chr8:8085844 FLJ10661 -0.4 -11.02 -0.4 5.82e-26 Neuroticism; BRCA cis rs2904967 0.929 rs2904986 chr11:65031221 A/C cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs4706831 0.647 rs9350847 chr6:80889017 C/T cg08355045 chr6:80787529 NA 0.31 7.83 0.3 2.04e-14 Joint mobility (Beighton score); BRCA cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg04455712 chr21:45112962 RRP1B 0.47 12.63 0.45 8.79e-33 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.54 -11.36 -0.41 2.39e-27 Lymphocyte counts; BRCA cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg26031613 chr14:104095156 KLC1 0.74 15.86 0.53 5.21e-48 Body mass index; BRCA cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg06636001 chr8:8085503 FLJ10661 0.43 7.92 0.3 1.03e-14 Obesity-related traits; BRCA cis rs17655565 0.533 rs12301094 chr12:52707610 A/G cg08257133 chr12:52711352 KRT83 0.38 11.29 0.41 4.43e-27 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs425277 1.000 rs262665 chr1:2083173 A/G cg00981070 chr1:2046702 PRKCZ 0.31 8.23 0.31 1.07e-15 Height; BRCA trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg15605315 chr1:45957053 TESK2 0.49 10.0 0.37 5.63e-22 High light scatter reticulocyte count; BRCA cis rs16866061 0.962 rs72972361 chr2:225341550 G/A cg12698349 chr2:225449008 CUL3 0.77 21.11 0.64 1.92e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs11190604 1.000 rs7088827 chr10:102303865 C/G cg07080220 chr10:102295463 HIF1AN 0.65 15.35 0.52 1.65e-45 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7918232 0.941 rs1755399 chr10:27394958 A/G cg14240646 chr10:27532245 ACBD5 -0.64 -9.36 -0.35 1.38e-19 Breast cancer; BRCA cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg07636037 chr3:49044803 WDR6 0.98 29.32 0.76 2.17e-120 Parkinson's disease; BRCA cis rs96067 0.711 rs272827 chr1:36627191 C/T cg24686825 chr1:36642396 MAP7D1 0.56 11.44 0.41 1.05e-27 Corneal structure; BRCA cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg21017887 chr14:105400489 NA 0.66 17.54 0.57 1.6e-56 Rheumatoid arthritis; BRCA cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg00686598 chr14:53173677 PSMC6 1.16 15.76 0.53 1.68e-47 Alzheimer's disease (late onset); BRCA cis rs12579753 0.871 rs1922540 chr12:82197496 A/G cg07988820 chr12:82153109 PPFIA2 -0.66 -10.65 -0.39 1.77e-24 Resting heart rate; BRCA cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg12935359 chr14:103987150 CKB 0.6 13.69 0.48 1.35e-37 Intelligence (multi-trait analysis); BRCA trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg15556689 chr8:8085844 FLJ10661 0.41 10.36 0.38 2.4e-23 Neuroticism; BRCA cis rs7520050 0.966 rs7556436 chr1:46363880 C/T cg24296786 chr1:45957014 TESK2 -0.41 -9.38 -0.35 1.16e-19 Red blood cell count;Reticulocyte count; BRCA trans rs629535 0.773 rs569064 chr8:70065967 A/G cg21567404 chr3:27674614 NA 1.01 20.67 0.63 4.59e-73 Dupuytren's disease; BRCA cis rs12612619 0.732 rs722911 chr2:27211212 A/G cg00617064 chr2:27272375 NA -0.31 -8.03 -0.3 4.8e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg25208724 chr1:156163844 SLC25A44 0.88 17.63 0.57 5.29e-57 Testicular germ cell tumor; BRCA cis rs250677 0.687 rs250674 chr5:148438597 A/G cg23229984 chr5:148520753 ABLIM3 -0.36 -9.13 -0.34 8.68e-19 Breast cancer; BRCA cis rs11229555 0.609 rs12575080 chr11:58224917 A/G cg15696309 chr11:58395628 NA -0.53 -10.93 -0.4 1.29e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12220238 0.730 rs4746177 chr10:75913033 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.49 8.04 0.3 4.22e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg06026331 chr20:60912101 LAMA5 0.46 8.55 0.32 9.35e-17 Colorectal cancer; BRCA cis rs632111 0.519 rs281380 chr19:49214470 A/G cg13540341 chr19:49222985 MAMSTR 0.33 8.57 0.32 7.76e-17 Serum lipase activity; BRCA cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -14.24 -0.49 3.59e-40 Cognitive function; BRCA cis rs2404602 0.622 rs9635380 chr15:77103479 A/G cg23625390 chr15:77176239 SCAPER -0.57 -13.21 -0.46 2.03e-35 Blood metabolite levels; BRCA cis rs1506636 0.962 rs2896335 chr7:123376855 A/T cg03229431 chr7:123269106 ASB15 -0.61 -13.88 -0.48 1.77e-38 Plateletcrit;Platelet count; BRCA cis rs6089584 0.566 rs6061964 chr20:60607536 G/A cg13770153 chr20:60521292 NA -0.38 -9.1 -0.34 1.18e-18 Body mass index; BRCA cis rs700590 0.532 rs17558396 chr5:88102281 T/G cg22951263 chr5:87985283 NA -0.35 -8.89 -0.33 6.33e-18 Educational attainment (years of education); BRCA cis rs7647973 0.593 rs55997059 chr3:49858661 A/T cg03060546 chr3:49711283 APEH -0.56 -9.96 -0.37 7.79e-22 Menarche (age at onset); BRCA cis rs926392 0.572 rs6129159 chr20:37675011 A/T cg16355469 chr20:37678765 NA 0.5 11.73 0.42 6.74e-29 Dialysis-related mortality; BRCA trans rs7746199 0.736 rs13210634 chr6:27646492 A/G cg01620082 chr3:125678407 NA -0.92 -10.33 -0.38 2.97e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs698833 0.892 rs698801 chr2:44691662 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.32 0.38 3.3e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg05025164 chr4:1340916 KIAA1530 0.43 9.66 0.36 1.08e-20 Longevity; BRCA cis rs16958440 1.000 rs62096469 chr18:44638298 A/G cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07256732 chr16:621771 PIGQ -0.35 -9.26 -0.34 3.04e-19 Height; BRCA cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg06484146 chr7:12443880 VWDE -0.76 -10.59 -0.39 2.94e-24 Coronary artery disease; BRCA cis rs13102973 0.965 rs28826933 chr4:135876644 T/A cg14419869 chr4:135874104 NA -0.59 -13.0 -0.46 1.93e-34 Subjective well-being; BRCA cis rs6867032 1.000 rs10462750 chr5:2012963 A/G cg26168224 chr5:2018326 NA 0.63 17.39 0.57 9.07e-56 Gut microbiome composition (winter); BRCA cis rs6580649 1.000 rs7305954 chr12:48403530 C/T cg24011408 chr12:48396354 COL2A1 0.53 9.56 0.35 2.49e-20 Lung cancer; BRCA cis rs2559856 1.000 rs10778139 chr12:102083202 C/T cg12213457 chr12:102090980 CHPT1 0.36 8.04 0.3 4.25e-15 Blood protein levels; BRCA trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg13010199 chr12:38710504 ALG10B 0.42 8.97 0.33 3.36e-18 Morning vs. evening chronotype; BRCA cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg05347473 chr6:146136440 FBXO30 0.39 7.98 0.3 6.65e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2463822 0.844 rs2513737 chr11:62119495 G/C cg06239285 chr11:62104954 ASRGL1 0.69 11.52 0.41 4.72e-28 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs11098499 0.955 rs13114751 chr4:120156617 G/A cg09307838 chr4:120376055 NA 0.61 11.94 0.43 8.48e-30 Corneal astigmatism; BRCA cis rs6450176 0.638 rs56220547 chr5:53287952 A/G ch.5.1024479R chr5:53302184 ARL15 -0.9 -17.78 -0.58 9.16e-58 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7592578 0.771 rs12052514 chr2:191378170 C/T cg11845111 chr2:191398756 TMEM194B -0.73 -14.25 -0.49 3.37e-40 Diastolic blood pressure; BRCA cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg02569458 chr12:86230093 RASSF9 0.32 8.01 0.3 5.6e-15 Major depressive disorder; BRCA cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg18357645 chr12:58087776 OS9 0.43 11.99 0.43 4.94e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -8.78 -0.33 1.53e-17 Longevity;Endometriosis; BRCA cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg09462578 chr12:12878428 APOLD1 0.5 11.88 0.43 1.51e-29 Birth weight; BRCA cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg16339924 chr4:17578868 LAP3 -0.55 -13.28 -0.47 9.99e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.61e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg01448562 chr3:133502909 NA -0.48 -10.48 -0.38 8.26e-24 Iron status biomarkers; BRCA cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg04287289 chr16:89883240 FANCA 0.81 20.35 0.63 2.51e-71 Vitiligo; BRCA cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg18876405 chr7:65276391 NA -0.51 -11.54 -0.42 3.95e-28 Aortic root size; BRCA cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.77e-26 Extrinsic epigenetic age acceleration; BRCA cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg01579765 chr21:45077557 HSF2BP -0.37 -9.96 -0.37 8.18e-22 Mean corpuscular volume; BRCA cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11890956 chr21:40555474 PSMG1 -0.65 -14.71 -0.5 2.19e-42 Menarche (age at onset); BRCA trans rs7615952 0.576 rs2276726 chr3:125826287 C/G cg07211511 chr3:129823064 LOC729375 -0.6 -11.36 -0.41 2.27e-27 Blood pressure (smoking interaction); BRCA cis rs365132 0.517 rs6881002 chr5:176336755 T/C cg16309518 chr5:176445507 NA 0.44 10.32 0.38 3.4e-23 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs250677 0.687 rs168750 chr5:148446756 A/G cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.89e-31 Breast cancer; BRCA cis rs6570726 0.967 rs441364 chr6:145853662 G/C cg23711669 chr6:146136114 FBXO30 0.64 14.94 0.51 1.74e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs4268898 0.722 rs7563958 chr2:24422381 C/A cg26838691 chr2:24397539 C2orf84 0.39 7.93 0.3 9.84e-15 Asthma; BRCA cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.95e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs8073060 0.544 rs1080352 chr17:34002362 A/G cg19694781 chr19:47549865 TMEM160 -1.03 -21.11 -0.64 1.9e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg13628971 chr7:2884303 GNA12 0.47 9.02 0.34 2.13e-18 Height; BRCA cis rs6138458 1.000 rs227624 chr20:24911562 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.38 -0.31 3.34e-16 Blood protein levels; BRCA cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06481639 chr22:41940642 POLR3H 0.52 8.08 0.3 3.3e-15 Vitiligo; BRCA cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg03808351 chr9:123631620 PHF19 0.61 12.76 0.45 2.26e-33 Birth weight; BRCA cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.01 0.4 6.14e-26 Electroencephalogram traits; BRCA cis rs290268 0.838 rs290987 chr9:93563267 T/A cg02608019 chr9:93564028 SYK 0.55 12.23 0.44 4.54e-31 Platelet count; BRCA cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg12311346 chr5:56204834 C5orf35 -0.81 -16.67 -0.55 4.73e-52 Initial pursuit acceleration; BRCA cis rs12541635 0.966 rs4734894 chr8:106995313 G/A cg10147462 chr8:107024639 NA 0.38 9.94 0.37 9.45e-22 Age of smoking initiation; BRCA cis rs2882667 0.893 rs10054796 chr5:138294344 G/A cg04439458 chr5:138467593 SIL1 -0.32 -8.54 -0.32 1.01e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs8180040 0.966 rs17784882 chr3:47544003 C/A cg27129171 chr3:47204927 SETD2 -0.66 -15.06 -0.51 4.17e-44 Colorectal cancer; BRCA cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg27478167 chr7:817139 HEATR2 -0.48 -9.31 -0.35 1.99e-19 Cerebrospinal P-tau181p levels; BRCA cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg05347473 chr6:146136440 FBXO30 0.58 11.2 0.41 1.05e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg15017067 chr4:17643749 FAM184B 0.31 9.52 0.35 3.61e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12618769 0.652 rs4851144 chr2:99220707 T/C cg10123293 chr2:99228465 UNC50 0.44 8.66 0.32 3.93e-17 Bipolar disorder; BRCA cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.6 0.39 2.78e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7618501 0.538 rs9856572 chr3:50109073 A/T cg24110177 chr3:50126178 RBM5 0.4 11.28 0.41 4.87e-27 Intelligence (multi-trait analysis); BRCA cis rs796364 0.616 rs7574313 chr2:200681040 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.34 0.31 4.51e-16 Schizophrenia; BRCA cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg00071950 chr4:10020882 SLC2A9 -0.48 -10.95 -0.4 1.1e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg11764359 chr7:65958608 NA 0.78 18.57 0.59 6.75e-62 Aortic root size; BRCA cis rs9400271 0.632 rs9384706 chr6:109601504 C/T cg21918786 chr6:109611834 NA -0.32 -8.01 -0.3 5.44e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg12923728 chr3:195709715 SDHAP1 -0.58 -12.41 -0.44 7.61e-32 Pancreatic cancer; BRCA cis rs9325144 0.555 rs4550281 chr12:38689937 A/G cg26384229 chr12:38710491 ALG10B 0.54 13.7 0.48 1.18e-37 Morning vs. evening chronotype; BRCA cis rs4074536 0.622 rs12741300 chr1:116319761 C/T cg21648376 chr1:116311395 CASQ2 -0.55 -9.15 -0.34 7.82e-19 QRS duration; BRCA cis rs9399135 0.935 rs11759999 chr6:135370495 G/T cg24558204 chr6:135376177 HBS1L 0.45 12.24 0.44 4.37e-31 Red blood cell count; BRCA cis rs921968 0.565 rs6704575 chr2:219589594 C/T cg02176678 chr2:219576539 TTLL4 0.4 11.02 0.4 5.46e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9325144 0.560 rs10785573 chr12:38654166 G/A cg13010199 chr12:38710504 ALG10B -0.39 -8.83 -0.33 1.04e-17 Morning vs. evening chronotype; BRCA cis rs8050907 0.744 rs8044698 chr16:4577069 A/G cg02873098 chr16:4524103 NMRAL1;HMOX2 -0.56 -8.22 -0.31 1.15e-15 Obesity-related traits; BRCA cis rs10754283 0.967 rs7523046 chr1:90109499 G/A cg21401794 chr1:90099060 LRRC8C 0.49 11.63 0.42 1.69e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs10876993 0.890 rs1689584 chr12:58081478 G/A cg18357645 chr12:58087776 OS9 0.48 13.8 0.48 4.14e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7737355 0.947 rs6875058 chr5:130882702 C/G cg06307176 chr5:131281290 NA 0.54 10.68 0.39 1.3e-24 Life satisfaction; BRCA cis rs1153858 1.000 rs16952714 chr15:45650358 G/A cg14582100 chr15:45693742 SPATA5L1 0.37 11.87 0.42 1.69e-29 Homoarginine levels; BRCA cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg19077165 chr18:44547161 KATNAL2 -0.55 -12.55 -0.44 1.8e-32 Personality dimensions; BRCA cis rs3845702 0.736 rs72960660 chr2:180832482 A/G cg01881094 chr2:180872142 CWC22 1.03 16.85 0.55 5.75e-53 Schizophrenia; BRCA cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg02297831 chr4:17616191 MED28 0.36 8.51 0.32 1.21e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6543140 0.964 rs6543142 chr2:103082006 T/C cg04239558 chr2:103089729 SLC9A4 0.35 9.74 0.36 5.21e-21 Blood protein levels; BRCA cis rs9467773 0.620 rs2504592 chr6:26640951 C/G cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.76e-30 Intelligence (multi-trait analysis); BRCA cis rs7829975 0.606 rs10112585 chr8:8795030 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -11.85 -0.42 2.08e-29 Mood instability; BRCA cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg06766960 chr11:133703094 NA -0.51 -11.5 -0.41 6.1e-28 Childhood ear infection; BRCA cis rs2191566 0.540 rs391267 chr19:44492487 C/T cg20607764 chr19:44506953 ZNF230 0.37 7.9 0.3 1.19e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs6908034 0.607 rs76525593 chr6:19809170 G/T cg02682789 chr6:19804855 NA 0.75 8.8 0.33 1.25e-17 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg16606324 chr3:10149918 C3orf24 -0.51 -10.57 -0.39 3.54e-24 Alzheimer's disease; BRCA cis rs243505 0.762 rs734002 chr7:148505788 A/G cg09806900 chr7:148480153 CUL1 0.48 10.18 0.37 1.13e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.19 -0.43 6.98e-31 Alzheimer's disease; BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -10.88 -0.4 2.04e-25 Alzheimer's disease; BRCA cis rs7727544 0.684 rs272869 chr5:131677997 A/G cg07395648 chr5:131743802 NA -0.39 -9.59 -0.35 1.93e-20 Blood metabolite levels; BRCA cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg11764359 chr7:65958608 NA -0.62 -13.41 -0.47 2.62e-36 Aortic root size; BRCA cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg18132916 chr6:79620363 NA -0.44 -10.07 -0.37 3.15e-22 Intelligence (multi-trait analysis); BRCA trans rs2562456 0.874 rs2562408 chr19:21709881 C/G cg25042112 chr7:64838748 ZNF92 0.46 8.4 0.32 2.96e-16 Pain; BRCA cis rs4478858 0.684 rs4949369 chr1:31723845 T/A cg00250761 chr1:31883323 NA -0.31 -8.14 -0.31 2.02e-15 Alcohol dependence; BRCA cis rs10242455 0.557 rs45492501 chr7:99047030 T/A cg18809830 chr7:99032528 PTCD1 -0.61 -8.86 -0.33 7.76e-18 Blood metabolite levels; BRCA cis rs61935443 0.832 rs10859778 chr12:95268010 C/G cg21533806 chr12:95267307 NA 0.45 8.56 0.32 8.66e-17 Schizophrenia; BRCA trans rs6582630 0.519 rs11514078 chr12:38408817 G/C cg06521331 chr12:34319734 NA -0.47 -8.59 -0.32 6.55e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7246657 0.606 rs2972439 chr19:38212581 T/C cg14683738 chr19:37701593 ZNF585B -0.47 -8.02 -0.3 5.04e-15 Coronary artery calcification; BRCA cis rs769267 1.000 rs769267 chr19:19446936 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.42 0.35 8.17e-20 Tonsillectomy; BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg00149659 chr3:10157352 C3orf10 0.71 12.11 0.43 1.54e-30 Alzheimer's disease; BRCA cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg25358565 chr5:93447407 FAM172A 1.23 19.18 0.6 4.21e-65 Diabetic retinopathy; BRCA cis rs7737355 0.898 rs1016068 chr5:131100246 T/C cg06307176 chr5:131281290 NA 0.53 10.2 0.37 9.47e-23 Life satisfaction; BRCA cis rs477692 0.905 rs4751106 chr10:131424653 G/T cg05714579 chr10:131428358 MGMT -0.59 -14.59 -0.5 7.6e-42 Response to temozolomide; BRCA trans rs9858542 0.953 rs10640 chr3:49454277 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.65 -0.36 1.18e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs56399783 0.614 rs11765492 chr7:2771642 G/A cg19731401 chr7:2775893 GNA12 0.53 8.43 0.32 2.34e-16 Childhood ear infection; BRCA cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.28 0.56 3.52e-55 Drug-induced liver injury (flucloxacillin); BRCA trans rs2204008 0.604 rs2320521 chr12:38253789 A/G cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Bladder cancer; BRCA cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.71 13.17 0.46 3.35e-35 Lung function (FEV1/FVC); BRCA cis rs701145 0.585 rs1527800 chr3:153875075 A/G cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs7254827 0.826 rs62127867 chr19:17223260 C/T cg19418318 chr19:17219073 MYO9B -0.51 -10.32 -0.38 3.28e-23 Mean platelet volume; BRCA trans rs6951245 0.554 rs35126802 chr7:1134842 C/T cg13565492 chr6:43139072 SRF -0.89 -16.05 -0.54 5.92e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6910061 0.830 rs7753943 chr6:11133496 T/G cg27233058 chr6:11094804 LOC221710 0.51 8.73 0.33 2.24e-17 Diabetic kidney disease; BRCA cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg12573674 chr2:1569213 NA -0.58 -12.76 -0.45 2.18e-33 IgG glycosylation; BRCA trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg03929089 chr4:120376271 NA 0.72 14.67 0.5 3.35e-42 Coronary artery disease; BRCA cis rs634534 0.563 rs470192 chr11:65724291 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.59 13.19 0.46 2.71e-35 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs4930103 0.904 rs4929984 chr11:2024683 A/C cg06197492 chr11:2016605 H19 -0.39 -8.72 -0.33 2.49e-17 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg15485101 chr11:133734466 NA 0.38 10.33 0.38 3.21e-23 Childhood ear infection; BRCA cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.835 rs946525 chr1:46487277 A/T cg03146154 chr1:46216737 IPP -0.45 -10.13 -0.37 1.84e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4664304 0.620 rs10929958 chr2:160720538 A/G cg01092293 chr2:160761427 LY75 0.36 8.51 0.32 1.24e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg01305625 chr5:131593812 PDLIM4 0.34 8.07 0.3 3.4e-15 Acylcarnitine levels; BRCA cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.46 0.32 1.84e-16 Diabetic retinopathy; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.07 -0.34 1.47e-18 Total body bone mineral density; BRCA cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg06026331 chr20:60912101 LAMA5 0.46 8.46 0.32 1.89e-16 Colorectal cancer; BRCA cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg00631329 chr6:26305371 NA -0.44 -12.86 -0.45 8.01e-34 Educational attainment; BRCA cis rs7617773 0.780 rs71323396 chr3:48374734 T/G cg11946769 chr3:48343235 NME6 0.65 13.41 0.47 2.71e-36 Coronary artery disease; BRCA cis rs9393692 0.875 rs9393690 chr6:26271713 A/T cg00631329 chr6:26305371 NA -0.43 -12.72 -0.45 3.34e-33 Educational attainment; BRCA cis rs7312933 0.533 rs17551006 chr12:42848738 G/C cg01256987 chr12:42539512 GXYLT1 -0.41 -8.11 -0.31 2.64e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg07828340 chr4:882639 GAK 0.99 12.74 0.45 2.68e-33 Intelligence (multi-trait analysis); BRCA trans rs12310956 0.532 rs11608842 chr12:33951121 C/T cg26384229 chr12:38710491 ALG10B 0.46 10.13 0.37 1.85e-22 Morning vs. evening chronotype; BRCA cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg21226059 chr5:178986404 RUFY1 0.36 8.35 0.31 4.27e-16 Lung cancer; BRCA cis rs2011503 1.000 rs8110250 chr19:19559989 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.19 -0.34 5.27e-19 Bipolar disorder; BRCA cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg24130564 chr14:104152367 KLC1 0.61 17.33 0.57 1.84e-55 Intelligence (multi-trait analysis); BRCA cis rs10845606 1.000 rs10845610 chr12:12839107 G/A cg09462578 chr12:12878428 APOLD1 -0.63 -11.19 -0.4 1.13e-26 Systemic lupus erythematosus; BRCA cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.869 rs10250641 chr7:91490746 C/T cg17063962 chr7:91808500 NA 0.53 12.48 0.44 3.65e-32 Breast cancer; BRCA cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.06 0.49 2.57e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg11812906 chr14:75593930 NEK9 -0.62 -14.24 -0.49 3.57e-40 Height; BRCA cis rs1153858 1.000 rs7164602 chr15:45671325 A/G cg21132104 chr15:45694354 SPATA5L1 0.75 16.9 0.56 2.9e-53 Homoarginine levels; BRCA cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.36 0.31 3.82e-16 Bladder cancer; BRCA cis rs12135062 0.851 rs2651925 chr1:3101863 C/G cg21609526 chr1:3105151 PRDM16 0.36 8.61 0.32 5.72e-17 Migraine; BRCA cis rs2859741 0.587 rs516139 chr1:37471617 C/G cg09363841 chr1:37513479 NA -0.4 -8.28 -0.31 7.36e-16 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg13010199 chr12:38710504 ALG10B -0.43 -9.14 -0.34 8.07e-19 Morning vs. evening chronotype; BRCA cis rs672059 1.000 rs652753 chr1:183156569 A/T ch.1.3577855R chr1:183094577 LAMC1 0.37 8.64 0.32 4.48e-17 Hypertriglyceridemia; BRCA cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg26855724 chr1:75198818 TYW3;CRYZ -0.41 -8.01 -0.3 5.6e-15 Resistin levels; BRCA cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.29e-32 Developmental language disorder (linguistic errors); BRCA cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.57 0.32 7.52e-17 Glomerular filtration rate (creatinine); BRCA cis rs6546550 0.935 rs6546551 chr2:70073703 C/T cg02498382 chr2:70120550 SNRNP27 -0.49 -10.37 -0.38 2.07e-23 Prevalent atrial fibrillation; BRCA cis rs17376456 0.825 rs10078941 chr5:93279029 C/T cg25358565 chr5:93447407 FAM172A 1.16 18.32 0.59 1.36e-60 Diabetic retinopathy; BRCA cis rs13418410 0.539 rs11695597 chr2:33840024 A/G cg04131969 chr2:33951647 MYADML 0.52 10.42 0.38 1.33e-23 Non-response to antidepressants and depression; BRCA cis rs11098499 0.697 rs11941899 chr4:120382758 C/A cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs2249625 0.874 rs2463747 chr6:72878113 T/A cg18830697 chr6:72922368 RIMS1 -0.38 -8.06 -0.3 3.72e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg24642439 chr20:33292090 TP53INP2 -0.42 -8.69 -0.33 2.99e-17 Glomerular filtration rate (creatinine); BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg23978390 chr7:1156363 C7orf50 0.47 10.83 0.39 3.36e-25 Longevity;Endometriosis; BRCA cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg22535103 chr8:58192502 C8orf71 0.49 8.68 0.32 3.18e-17 Developmental language disorder (linguistic errors); BRCA cis rs765787 0.530 rs7165889 chr15:45531640 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.78e-15 Uric acid levels; BRCA cis rs4742903 0.967 rs2274725 chr9:106864570 C/T cg14250997 chr9:106856677 SMC2 0.34 10.68 0.39 1.31e-24 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg18279126 chr7:2041391 MAD1L1 0.37 8.51 0.32 1.28e-16 Bipolar disorder and schizophrenia; BRCA cis rs832540 0.552 rs252924 chr5:56205643 A/G cg12311346 chr5:56204834 C5orf35 -0.5 -10.15 -0.37 1.48e-22 Coronary artery disease; BRCA trans rs12517041 1.000 rs7736335 chr5:23288232 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.14 -0.31 2.11e-15 Calcium levels; BRCA cis rs7267979 1.000 rs6132835 chr20:25434667 A/G cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17253792 0.915 rs78089630 chr14:56178584 G/C cg01858014 chr14:56050164 KTN1 -0.67 -8.51 -0.32 1.22e-16 Putamen volume; BRCA cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg11279151 chr3:101281821 RG9MTD1 0.36 8.22 0.31 1.13e-15 Colorectal cancer; BRCA trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg22491629 chr6:157744540 C6orf35 -0.45 -9.33 -0.35 1.65e-19 Hemostatic factors and hematological phenotypes; BRCA cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg04553112 chr3:125709451 NA -0.55 -8.34 -0.31 4.41e-16 Blood pressure (smoking interaction); BRCA cis rs8170 0.603 rs971693 chr19:17422649 G/C cg04749549 chr19:17459798 NA -0.36 -9.8 -0.36 3.09e-21 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs6582630 0.539 rs12308081 chr12:38342881 C/G cg26384229 chr12:38710491 ALG10B -0.41 -9.46 -0.35 5.69e-20 Drug-induced liver injury (flucloxacillin); BRCA trans rs8002861 0.664 rs4941474 chr13:44450289 C/T cg17145862 chr1:211918768 LPGAT1 0.49 11.08 0.4 3.12e-26 Leprosy; BRCA cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.93 0.53 2.27e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs514406 0.929 rs564273 chr1:53332445 G/C cg27535305 chr1:53392650 SCP2 -0.37 -8.94 -0.33 4.07e-18 Monocyte count; BRCA cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg00071950 chr4:10020882 SLC2A9 -0.51 -11.65 -0.42 1.44e-28 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2243480 1.000 rs3885839 chr7:65290403 G/T cg18252515 chr7:66147081 NA -0.87 -12.06 -0.43 2.43e-30 Diabetic kidney disease; BRCA cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23221052 chr5:179740743 GFPT2 -0.64 -13.35 -0.47 5.05e-36 Height; BRCA trans rs7647973 0.626 rs9835157 chr3:49797769 G/A cg21659725 chr3:3221576 CRBN 0.48 8.7 0.33 2.83e-17 Menarche (age at onset); BRCA trans rs60843830 1.000 rs3791221 chr2:226933 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 14.38 0.49 7.95e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg26818010 chr10:134567672 INPP5A -0.63 -13.42 -0.47 2.33e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9400271 0.632 rs9374071 chr6:109588681 T/C cg01475377 chr6:109611718 NA -0.44 -10.41 -0.38 1.56e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7264396 0.790 rs2425125 chr20:34330954 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.75 16.16 0.54 1.65e-49 Total cholesterol levels; BRCA cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg02551604 chr5:131831745 NA -0.31 -11.37 -0.41 2.17e-27 Breast cancer;Mosquito bite size; BRCA cis rs7560272 0.501 rs2421674 chr2:73955432 G/A cg20560298 chr2:73613845 ALMS1 0.34 8.7 0.33 2.9e-17 Schizophrenia; BRCA cis rs2304069 1.000 rs10072275 chr5:149401596 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.76 15.75 0.53 1.79e-47 HIV-1 control; BRCA cis rs941873 0.805 rs8837 chr10:81114813 C/G cg08514558 chr10:81106712 PPIF 0.38 8.39 0.31 3.21e-16 Height; BRCA cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg01475377 chr6:109611718 NA -0.44 -11.11 -0.4 2.5e-26 Reticulocyte fraction of red cells; BRCA cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg23711669 chr6:146136114 FBXO30 -0.8 -19.65 -0.61 1.36e-67 Lobe attachment (rater-scored or self-reported); BRCA cis rs1577917 0.958 rs34230196 chr6:86526022 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs311392 0.867 rs367108 chr8:55093142 G/A cg11783602 chr8:55087084 NA -0.31 -9.12 -0.34 9.47e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs2304069 0.826 rs245076 chr5:149350648 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.49 11.44 0.41 1.08e-27 HIV-1 control; BRCA cis rs10911363 0.592 rs10911354 chr1:183489278 G/A cg09173681 chr1:183549694 NCF2 0.53 11.1 0.4 2.72e-26 Systemic lupus erythematosus; BRCA cis rs9325144 0.671 rs7306605 chr12:38730471 C/T cg26384229 chr12:38710491 ALG10B 0.49 12.32 0.44 1.84e-31 Morning vs. evening chronotype; BRCA cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg12463550 chr7:65579703 CRCP 0.38 8.15 0.31 1.96e-15 Aortic root size; BRCA cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg10556349 chr10:835070 NA 0.73 9.71 0.36 6.8e-21 Eosinophil percentage of granulocytes; BRCA cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03517284 chr6:25882590 NA 0.39 9.18 0.34 5.73e-19 Blood metabolite levels; BRCA cis rs6543140 0.964 rs4851578 chr2:103028951 T/G cg04239558 chr2:103089729 SLC9A4 0.34 9.38 0.35 1.16e-19 Blood protein levels; BRCA cis rs3820928 0.874 rs67513858 chr2:227804819 A/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.85 -0.33 8.28e-18 Pulmonary function; BRCA cis rs2066819 0.786 rs116934693 chr12:56696545 T/G cg26734620 chr12:56694298 CS 0.87 10.06 0.37 3.46e-22 Psoriasis vulgaris; BRCA trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21659725 chr3:3221576 CRBN -0.71 -21.59 -0.65 4.63e-78 Intelligence (multi-trait analysis); BRCA cis rs7927771 1.000 rs4752857 chr11:47655752 C/T cg18512352 chr11:47633146 NA -0.36 -8.81 -0.33 1.15e-17 Subjective well-being; BRCA trans rs61931739 0.500 rs7308338 chr12:34553181 A/G cg13010199 chr12:38710504 ALG10B 0.45 9.63 0.36 1.42e-20 Morning vs. evening chronotype; BRCA cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg21427119 chr20:30132790 HM13 0.41 8.71 0.33 2.49e-17 Mean corpuscular hemoglobin; BRCA cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg13319975 chr6:146136371 FBXO30 0.44 10.15 0.37 1.59e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs6545883 0.895 rs796597 chr2:61681060 A/G cg15711740 chr2:61764176 XPO1 -0.53 -12.8 -0.45 1.44e-33 Tuberculosis; BRCA cis rs4944092 1.000 rs4944092 chr11:75909619 C/T cg04588336 chr11:75916460 WNT11 -0.49 -11.87 -0.42 1.74e-29 PR interval; BRCA cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg08219700 chr8:58056026 NA 0.45 8.33 0.31 5.12e-16 Developmental language disorder (linguistic errors); BRCA cis rs13102973 0.867 rs4429776 chr4:135883394 G/T cg14419869 chr4:135874104 NA 0.46 9.1 0.34 1.15e-18 Subjective well-being; BRCA cis rs17376456 1.000 rs34854140 chr5:93538169 G/A cg25358565 chr5:93447407 FAM172A 1.17 18.76 0.6 6.73e-63 Diabetic retinopathy; BRCA cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg13319975 chr6:146136371 FBXO30 -0.42 -9.62 -0.36 1.5e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.818 rs423692 chr1:153005681 T/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs7246657 0.722 rs10404031 chr19:38035954 A/G cg23950597 chr19:37808831 NA -0.51 -8.65 -0.32 4.11e-17 Coronary artery calcification; BRCA trans rs4689592 0.546 rs2359012 chr4:7066053 A/C cg07817883 chr1:32538562 TMEM39B -0.44 -8.59 -0.32 6.41e-17 Monocyte percentage of white cells; BRCA cis rs9818758 0.607 rs9880088 chr3:49178990 G/A cg00383909 chr3:49044727 WDR6 0.78 13.01 0.46 1.69e-34 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs68170813 0.559 rs79543528 chr7:106891090 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.5 -0.32 1.3e-16 Coronary artery disease; BRCA cis rs4690686 0.500 rs11723131 chr4:177268602 G/A cg17059388 chr4:177262070 NA 0.51 10.7 0.39 1.05e-24 Essential tremor; BRCA trans rs3780486 0.846 rs10813948 chr9:33121570 G/A cg04842962 chr6:43655489 MRPS18A 1.13 38.18 0.83 5.2e-167 IgG glycosylation; BRCA cis rs4908760 0.965 rs12080583 chr1:8524877 G/A cg20416874 chr1:8611966 RERE -0.28 -8.08 -0.3 3.31e-15 Vitiligo; BRCA cis rs6772849 0.805 rs61159406 chr3:128336009 G/A cg16766828 chr3:128327626 NA -0.37 -8.59 -0.32 6.43e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg23029597 chr12:123009494 RSRC2 -0.59 -11.69 -0.42 9.28e-29 Body mass index; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -8.14 -0.31 2.02e-15 Longevity;Endometriosis; BRCA cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg13736514 chr6:26305472 NA -0.35 -11.92 -0.43 1.01e-29 Educational attainment; BRCA cis rs17767294 0.615 rs72845058 chr6:27647420 T/C cg08851530 chr6:28072375 NA 1.11 10.02 0.37 4.78e-22 Parkinson's disease; BRCA cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.42 0.32 2.54e-16 Morning vs. evening chronotype; BRCA cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.34 -0.41 2.88e-27 Electroencephalogram traits; BRCA cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 14.08 0.49 2.12e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.99 0.51 9.36e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg23029597 chr12:123009494 RSRC2 0.62 11.97 0.43 6e-30 Body mass index; BRCA cis rs4268898 0.662 rs35624938 chr2:24576651 T/C cg06627628 chr2:24431161 ITSN2 -0.84 -15.49 -0.52 3.48e-46 Asthma; BRCA cis rs1538970 0.924 rs1006216 chr1:45909994 A/G cg05343316 chr1:45956843 TESK2 0.62 12.54 0.44 2.15e-32 Platelet count; BRCA cis rs752010 0.746 rs10890146 chr1:42089389 G/A cg06885757 chr1:42089581 HIVEP3 0.3 10.85 0.39 2.8e-25 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2505998 0.833 rs2565204 chr10:43603173 T/C cg15436174 chr10:43711423 RASGEF1A -0.39 -7.87 -0.3 1.51e-14 Hirschsprung disease; BRCA cis rs1448094 0.512 rs12313775 chr12:86241197 G/A cg19622623 chr12:86230825 RASSF9 -0.33 -9.17 -0.34 6.19e-19 Major depressive disorder; BRCA cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs73242632 1.000 rs114513553 chr4:57858458 G/A cg20415529 chr4:57845134 POLR2B;C4orf14 0.7 8.49 0.32 1.4e-16 Congenital heart disease (maternal effect); BRCA cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg04450456 chr4:17643702 FAM184B 0.34 9.77 0.36 4.31e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9462027 0.628 rs2814970 chr6:34713500 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.0 -0.3 6.02e-15 Systemic lupus erythematosus; BRCA cis rs13394619 0.775 rs10200851 chr2:11722082 C/T cg07314298 chr2:11723111 GREB1 -0.55 -12.38 -0.44 1.04e-31 Endometriosis; BRCA cis rs57221529 0.563 rs4957057 chr5:569230 C/G cg09021430 chr5:549028 NA -0.66 -16.47 -0.55 4.57e-51 Lung disease severity in cystic fibrosis; BRCA cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg24558204 chr6:135376177 HBS1L 0.57 15.55 0.52 1.67e-46 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg00074818 chr8:8560427 CLDN23 0.38 8.27 0.31 7.59e-16 Obesity-related traits; BRCA cis rs4073582 0.516 rs1151539 chr11:66031660 C/T cg16950941 chr11:66035639 RAB1B 0.46 12.3 0.44 2.24e-31 Gout; BRCA cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg05347473 chr6:146136440 FBXO30 0.41 7.96 0.3 8.08e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg11168104 chr5:1857477 NA -0.37 -9.55 -0.35 2.63e-20 Cardiovascular disease risk factors; BRCA cis rs9325144 0.624 rs10783330 chr12:39114084 A/G cg26384229 chr12:38710491 ALG10B -0.42 -10.13 -0.37 1.79e-22 Morning vs. evening chronotype; BRCA cis rs1113500 0.933 rs10881497 chr1:108634515 A/G cg06207961 chr1:108661230 NA -0.46 -11.19 -0.4 1.2e-26 Growth-regulated protein alpha levels; BRCA cis rs1997103 1.000 rs2331068 chr7:55408220 G/A cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs910316 0.967 rs4903293 chr14:75656568 A/G cg08847533 chr14:75593920 NEK9 -0.85 -21.27 -0.64 2.64e-76 Height; BRCA cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg08213375 chr14:104286397 PPP1R13B 0.41 8.81 0.33 1.16e-17 Reticulocyte count; BRCA cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 15.35 0.52 1.64e-45 Colorectal cancer; BRCA cis rs1799922 0.693 rs339085 chr7:128423763 T/C cg02354431 chr7:128423266 NA 0.37 9.4 0.35 9.22e-20 Primary tooth development (number of teeth);Primary tooth development (time to first tooth eruption); BRCA cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg10621924 chr7:39171070 POU6F2 0.38 7.93 0.3 9.68e-15 IgG glycosylation; BRCA cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg22875332 chr1:76189707 ACADM 0.65 12.42 0.44 7.12e-32 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs2562456 0.876 rs11085465 chr19:21751790 A/G cg25042112 chr7:64838748 ZNF92 0.45 8.31 0.31 5.93e-16 Pain; BRCA cis rs7552404 0.889 rs1250874 chr1:76190978 A/G cg22875332 chr1:76189707 ACADM 0.66 15.77 0.53 1.41e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg17420585 chr12:42539391 GXYLT1 -0.49 -10.57 -0.39 3.52e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs67981189 0.896 rs2526882 chr14:71374702 G/A cg15816911 chr14:71606274 NA -0.38 -8.31 -0.31 5.77e-16 Schizophrenia; BRCA cis rs3857067 0.773 rs10023115 chr4:95095502 G/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.44 -0.35 6.72e-20 QT interval; BRCA cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.68 -0.55 4.02e-52 Axial length; BRCA cis rs250677 0.522 rs10042466 chr5:148393634 T/C cg12140854 chr5:148520817 ABLIM3 -0.4 -8.34 -0.31 4.41e-16 Breast cancer; BRCA cis rs7772486 0.805 rs4896831 chr6:145959481 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.15 0.56 1.55e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs66887589 0.777 rs1814815 chr4:120258091 C/T cg09307838 chr4:120376055 NA 0.44 9.63 0.36 1.43e-20 Diastolic blood pressure; BRCA trans rs453301 0.571 rs330048 chr8:9087278 A/C cg15556689 chr8:8085844 FLJ10661 -0.42 -12.03 -0.43 3.42e-30 Joint mobility (Beighton score); BRCA cis rs9807989 0.507 rs2310300 chr2:103049074 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma; BRCA cis rs2882667 0.858 rs6882112 chr5:138413735 C/T cg04439458 chr5:138467593 SIL1 0.41 10.7 0.39 1.08e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3784262 0.631 rs3742961 chr15:58247977 T/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.77 -0.36 4.26e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs17376456 0.825 rs10214278 chr5:93237679 C/T cg21475434 chr5:93447410 FAM172A -0.61 -8.12 -0.31 2.43e-15 Diabetic retinopathy; BRCA cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11644478 chr21:40555479 PSMG1 -0.68 -14.6 -0.5 7.17e-42 Cognitive function; BRCA cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.09 0.4 2.84e-26 Rheumatoid arthritis; BRCA trans rs9291683 0.551 rs2240720 chr4:10020480 C/T cg26043149 chr18:55253948 FECH 0.39 8.36 0.31 3.78e-16 Bone mineral density; BRCA cis rs6545883 0.540 rs11687956 chr2:61851342 T/C cg15711740 chr2:61764176 XPO1 0.45 10.77 0.39 5.86e-25 Tuberculosis; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg03929089 chr4:120376271 NA -0.86 -21.63 -0.65 2.89e-78 Coronary artery disease; BRCA cis rs12586317 0.547 rs77780729 chr14:35496176 C/A cg05294307 chr14:35346193 BAZ1A -0.63 -10.62 -0.39 2.34e-24 Psoriasis; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg03188948 chr7:1209495 NA 0.64 13.23 0.46 1.76e-35 Longevity;Endometriosis; BRCA cis rs6545883 0.826 rs777591 chr2:61417617 A/G cg15711740 chr2:61764176 XPO1 -0.51 -12.87 -0.45 7.37e-34 Tuberculosis; BRCA cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs459571 0.606 rs457420 chr9:136909261 A/G cg13789015 chr9:136890014 NCRNA00094 -0.53 -11.64 -0.42 1.48e-28 Platelet distribution width; BRCA cis rs6909752 0.651 rs34930763 chr6:22557915 C/G cg13666174 chr6:22585274 NA -0.35 -7.95 -0.3 8.62e-15 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; BRCA cis rs2742234 0.590 rs2505557 chr10:43666016 C/T cg15436174 chr10:43711423 RASGEF1A -0.55 -10.93 -0.4 1.27e-25 Hirschsprung disease; BRCA cis rs9914988 0.943 rs59461345 chr17:27151852 G/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.88 -0.33 6.75e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs61931739 0.517 rs10844727 chr12:34017435 C/T cg26384229 chr12:38710491 ALG10B 0.53 11.49 0.41 6.32e-28 Morning vs. evening chronotype; BRCA cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7633770 0.786 rs4234464 chr3:46679675 C/T cg11219411 chr3:46661640 NA -0.62 -16.26 -0.54 5.43e-50 Coronary artery disease; BRCA cis rs9560113 1.000 rs2104790 chr13:112177412 C/T cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.88e-14 Menarche (age at onset); BRCA trans rs61931739 0.571 rs4001689 chr12:34243271 C/T cg26384229 chr12:38710491 ALG10B 0.65 13.96 0.48 7.74e-39 Morning vs. evening chronotype; BRCA cis rs9788682 0.747 rs2958719 chr15:78743029 G/A cg24631222 chr15:78858424 CHRNA5 -0.5 -9.91 -0.37 1.2e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg06238570 chr21:40685208 BRWD1 -0.39 -7.87 -0.3 1.47e-14 Menarche (age at onset); BRCA cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.58 -12.87 -0.45 7.18e-34 IgG glycosylation; BRCA cis rs4242434 0.927 rs2291234 chr8:22464390 T/C cg03733263 chr8:22462867 KIAA1967 1.0 24.43 0.69 1.35e-93 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs10464366 0.843 rs12701691 chr7:39090177 T/G cg18850127 chr7:39170497 POU6F2 0.38 7.96 0.3 7.63e-15 IgG glycosylation; BRCA cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg10495392 chr1:46806563 NSUN4 0.43 7.87 0.3 1.51e-14 Menopause (age at onset); BRCA cis rs9467773 1.000 rs2393670 chr6:26535541 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg11887960 chr12:57824829 NA 0.55 8.57 0.32 7.74e-17 Lung disease severity in cystic fibrosis; BRCA trans rs526821 0.595 rs499446 chr11:55355722 A/G cg11707556 chr5:10655725 ANKRD33B -0.35 -7.82 -0.3 2.22e-14 Pediatric bone mineral density (spine); BRCA cis rs12971120 1.000 rs734559 chr18:72179579 G/A cg26446133 chr18:72167187 CNDP2 -0.76 -14.49 -0.5 2.49e-41 Refractive error; BRCA trans rs10771431 0.817 rs17202253 chr12:9361850 A/G cg27600084 chr12:12264075 NA 0.37 8.53 0.32 1.06e-16 Breast size; BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.62 -13.18 -0.46 3.04e-35 Lymphocyte counts; BRCA cis rs2130392 0.962 rs7660116 chr4:185626542 G/A cg21366198 chr4:185655624 MLF1IP -0.39 -9.29 -0.34 2.42e-19 Kawasaki disease; BRCA cis rs2108225 0.837 rs7810937 chr7:107447500 A/G cg18560240 chr7:107437656 SLC26A3 -0.54 -11.27 -0.41 5.44e-27 Ulcerative colitis; BRCA cis rs4730250 0.707 rs3729876 chr7:106786952 T/C cg02696742 chr7:106810147 HBP1 0.62 9.93 0.37 1.04e-21 Osteoarthritis; BRCA cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg24642439 chr20:33292090 TP53INP2 0.73 16.63 0.55 6.93e-52 Coronary artery disease; BRCA cis rs1401999 1.000 rs3805108 chr3:183691650 T/C cg20387954 chr3:183756860 HTR3D 0.45 10.28 0.38 4.88e-23 Anterior chamber depth; BRCA cis rs1065852 0.526 rs2097561 chr22:42389431 T/C cg22189786 chr22:42395067 WBP2NL 0.41 8.32 0.31 5.17e-16 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.67 0.36 9.54e-21 Gut microbiome composition (summer); BRCA cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg15112475 chr7:1198522 ZFAND2A -0.38 -8.22 -0.31 1.14e-15 Longevity;Endometriosis; BRCA cis rs3743102 0.591 rs12148608 chr15:83382102 A/G cg00614314 chr15:82944287 LOC80154 0.59 8.39 0.32 3.09e-16 Colorectal adenoma (advanced); BRCA cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg06784218 chr1:46089804 CCDC17 -0.45 -10.49 -0.38 7.02e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg22920501 chr2:26401640 FAM59B -0.95 -16.58 -0.55 1.27e-51 Gut microbiome composition (summer); BRCA cis rs644148 0.676 rs2571114 chr19:44997579 A/G cg15540054 chr19:45004280 ZNF180 -0.42 -8.7 -0.33 2.71e-17 Personality dimensions; BRCA cis rs9790314 1.000 rs6794601 chr3:160946769 C/T cg03342759 chr3:160939853 NMD3 -0.64 -14.77 -0.5 1.11e-42 Morning vs. evening chronotype; BRCA cis rs11711311 1.000 rs7622515 chr3:113472538 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.76 -0.39 6.47e-25 IgG glycosylation; BRCA cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg13770153 chr20:60521292 NA -0.39 -9.17 -0.34 6.38e-19 Body mass index; BRCA cis rs250677 0.522 rs10040598 chr5:148365720 C/A cg18129178 chr5:148520854 ABLIM3 0.54 10.35 0.38 2.49e-23 Breast cancer; BRCA cis rs1691799 0.899 rs4762091 chr12:66747863 A/G cg16791601 chr12:66731901 HELB -0.69 -19.39 -0.61 3.39e-66 White blood cell count (basophil); BRCA cis rs910316 0.935 rs175076 chr14:75505486 A/G cg11812906 chr14:75593930 NEK9 -0.61 -13.96 -0.48 7.78e-39 Height; BRCA cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg00071950 chr4:10020882 SLC2A9 -0.46 -10.89 -0.4 1.84e-25 Bone mineral density; BRCA cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.83 -0.51 5.41e-43 Chronic sinus infection; BRCA trans rs1422110 0.543 rs10035841 chr5:85419597 T/C cg01787110 chr1:109008453 NBPF6 0.48 10.56 0.39 3.77e-24 Attention function in attention deficit hyperactive disorder; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg03923535 chr7:1197113 ZFAND2A 0.4 8.3 0.31 5.99e-16 Longevity;Endometriosis; BRCA cis rs7727544 0.684 rs274561 chr5:131719228 A/C cg24060327 chr5:131705240 SLC22A5 -0.44 -8.95 -0.33 3.84e-18 Blood metabolite levels; BRCA cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg13877915 chr19:58951672 ZNF132 0.47 11.13 0.4 2.03e-26 Uric acid clearance; BRCA cis rs9399135 0.967 rs34546690 chr6:135369709 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.27 0.44 3.13e-31 Red blood cell count; BRCA cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.33 -0.31 5.02e-16 Monocyte percentage of white cells; BRCA cis rs4481887 0.927 rs4350233 chr1:248489994 G/A cg00666640 chr1:248458726 OR2T12 0.32 8.94 0.33 4.09e-18 Common traits (Other); BRCA cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg23018236 chr17:30244563 NA -0.69 -11.83 -0.42 2.43e-29 Hip circumference adjusted for BMI; BRCA cis rs617791 0.678 rs551659 chr11:65749645 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.38 8.99 0.34 2.81e-18 Breast cancer; BRCA trans rs853679 0.769 rs7752608 chr6:28301195 A/G cg01620082 chr3:125678407 NA -0.57 -8.24 -0.31 1.01e-15 Depression; BRCA cis rs9359856 0.510 rs78649003 chr6:90454644 A/C cg13799429 chr6:90582589 CASP8AP2 -0.72 -10.97 -0.4 8.69e-26 Bipolar disorder; BRCA cis rs6867032 1.000 rs4975802 chr5:2019750 T/C cg26168224 chr5:2018326 NA 0.64 17.7 0.57 2.48e-57 Gut microbiome composition (winter); BRCA cis rs11190604 0.767 rs7090150 chr10:102173446 G/T cg07080220 chr10:102295463 HIF1AN 0.49 10.14 0.37 1.61e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg23711669 chr6:146136114 FBXO30 -0.77 -18.14 -0.58 1.18e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 1.000 rs17733640 chr3:38446742 G/A cg24069376 chr3:38537580 EXOG 0.4 11.21 0.41 9.31e-27 Electrocardiographic conduction measures; BRCA cis rs9329289 0.590 rs11251295 chr10:2563183 C/T cg15501526 chr10:2543763 NA 0.39 9.11 0.34 1.06e-18 Age-related hearing impairment; BRCA cis rs7246657 1.000 rs7246657 chr19:37747108 C/T cg23950597 chr19:37808831 NA 0.6 10.59 0.39 2.91e-24 Coronary artery calcification; BRCA cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.4 -0.35 9.22e-20 Body mass index; BRCA cis rs8141797 0.901 rs176159 chr22:24514352 A/G cg00411358 chr22:24577142 SUSD2 0.61 8.21 0.31 1.21e-15 Amyotrophic lateral sclerosis;Coronary artery disease; BRCA cis rs2658782 0.724 rs2248020 chr11:93259965 A/C cg15737290 chr11:93063684 CCDC67 0.49 10.0 0.37 5.54e-22 Pulmonary function decline; BRCA cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg26647111 chr11:31128758 NA -0.44 -9.68 -0.36 9.03e-21 Red blood cell count; BRCA cis rs17376456 0.825 rs13164315 chr5:93147421 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.74 0.33 2.02e-17 Diabetic retinopathy; BRCA cis rs66731853 0.769 rs530104 chr1:20895721 A/G cg24502330 chr1:20914028 CDA 0.32 7.92 0.3 1.08e-14 Mean corpuscular volume; BRCA cis rs34891900 0.507 rs2587084 chr22:18140644 T/G cg19898043 chr22:18121309 BCL2L13 0.45 9.05 0.34 1.66e-18 Sum neutrophil eosinophil counts; BRCA cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.3 0.44 2.25e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10791323 0.569 rs2298738 chr11:133715153 G/C cg14349672 chr11:133703707 NA -0.42 -9.39 -0.35 9.98e-20 Childhood ear infection; BRCA cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.68 -0.36 8.73e-21 Alcohol dependence; BRCA cis rs1005277 1.000 rs1005277 chr10:38218259 A/C cg25427524 chr10:38739819 LOC399744 0.5 9.34 0.35 1.6e-19 Extrinsic epigenetic age acceleration; BRCA cis rs8016982 0.855 rs10149681 chr14:81686319 G/A cg01989461 chr14:81687754 GTF2A1 0.52 11.19 0.4 1.1e-26 Schizophrenia; BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs11971779 1.000 rs75919582 chr7:139054919 G/A cg07862535 chr7:139043722 LUC7L2 0.51 11.36 0.41 2.29e-27 Diisocyanate-induced asthma; BRCA cis rs208520 0.690 rs176289 chr6:66766522 C/T cg07460842 chr6:66804631 NA -1.0 -19.99 -0.62 2.12e-69 Exhaled nitric oxide output; BRCA cis rs6582630 0.576 rs3900594 chr12:38272429 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.98 -0.37 6.84e-22 Drug-induced liver injury (flucloxacillin); BRCA trans rs6582630 0.537 rs1851124 chr12:38516404 G/A cg06521331 chr12:34319734 NA -0.47 -8.7 -0.33 2.8e-17 Drug-induced liver injury (flucloxacillin); BRCA trans rs9291683 0.530 rs11723591 chr4:9985398 T/A cg26043149 chr18:55253948 FECH 0.41 9.09 0.34 1.24e-18 Bone mineral density; BRCA cis rs17092148 1.000 rs57131731 chr20:33392739 C/T cg16810054 chr20:33298113 TP53INP2 0.49 11.17 0.4 1.35e-26 Neuroticism; BRCA cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg18904891 chr8:8559673 CLDN23 0.64 12.45 0.44 5.08e-32 Obesity-related traits; BRCA cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11890956 chr21:40555474 PSMG1 -0.6 -13.39 -0.47 3.1e-36 Menarche (age at onset); BRCA cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg20607287 chr7:12443886 VWDE -0.6 -8.53 -0.32 1.08e-16 Coronary artery disease; BRCA cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.39 -8.13 -0.31 2.16e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs61931739 0.517 rs4931748 chr12:34140827 C/T cg26384229 chr12:38710491 ALG10B 0.65 13.81 0.48 3.93e-38 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg02297831 chr4:17616191 MED28 -0.36 -8.31 -0.31 5.94e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17685 0.753 rs6951808 chr7:75772413 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1008375 0.966 rs1476836 chr4:17585014 G/C cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg08999081 chr20:33150536 PIGU 0.35 9.14 0.34 8.06e-19 Coronary artery disease; BRCA cis rs1577917 1.000 rs10944170 chr6:86685469 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.91 -0.43 1.17e-29 Response to antipsychotic treatment; BRCA cis rs61931739 0.517 rs7139189 chr12:34319757 T/C cg06521331 chr12:34319734 NA -0.65 -14.09 -0.49 1.84e-39 Morning vs. evening chronotype; BRCA cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg05985134 chr18:33552581 C18orf21 0.62 10.88 0.4 2.1e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2625529 0.938 rs4238447 chr15:72131880 C/T cg16672083 chr15:72433130 SENP8 -0.82 -17.03 -0.56 6.91e-54 Red blood cell count; BRCA cis rs4742903 0.967 rs2274725 chr9:106864570 C/T cg21169611 chr9:106856078 SMC2 0.36 9.32 0.35 1.85e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.53 8.56 0.32 8.66e-17 Renal function-related traits (BUN); BRCA cis rs4845570 1.000 rs1054479 chr1:151746079 A/T cg07092448 chr1:151763213 TDRKH -0.86 -16.92 -0.56 2.44e-53 Coronary artery disease; BRCA cis rs10924970 0.967 rs2185020 chr1:235440289 A/G cg26050004 chr1:235667680 B3GALNT2 0.35 8.69 0.33 3.01e-17 Asthma; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg04025307 chr7:1156635 C7orf50 0.58 13.73 0.48 8.83e-38 Longevity;Endometriosis; BRCA cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg25358565 chr5:93447407 FAM172A 1.15 19.28 0.61 1.24e-65 Diabetic retinopathy; BRCA cis rs4363385 0.818 rs4845512 chr1:152995241 C/T cg24667326 chr1:152973720 SPRR3 -0.32 -9.0 -0.34 2.54e-18 Inflammatory skin disease; BRCA cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.83 18.14 0.58 1.31e-59 Smoking behavior; BRCA cis rs57590327 0.555 rs6795133 chr3:81756267 A/G cg07356753 chr3:81810745 GBE1 -0.46 -11.07 -0.4 3.54e-26 Extraversion; BRCA cis rs11190604 1.000 rs6584379 chr10:102224490 G/A cg07080220 chr10:102295463 HIF1AN 0.49 10.97 0.4 8.83e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg16606324 chr3:10149918 C3orf24 0.52 10.29 0.38 4.44e-23 Alzheimer's disease; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg23708337 chr7:1209742 NA 0.6 13.79 0.48 4.85e-38 Longevity;Endometriosis; BRCA cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg08859206 chr1:53392774 SCP2 0.45 10.09 0.37 2.5e-22 Monocyte count; BRCA trans rs2204008 0.627 rs10878488 chr12:38148666 G/A cg06521331 chr12:34319734 NA -0.54 -9.6 -0.36 1.77e-20 Bladder cancer; BRCA cis rs17641971 0.684 rs1511367 chr8:49949412 T/C cg00325661 chr8:49890786 NA 0.38 10.67 0.39 1.43e-24 Blood metabolite levels; BRCA trans rs9858542 1.000 rs13085791 chr3:49721798 C/A cg21659725 chr3:3221576 CRBN -0.48 -10.29 -0.38 4.33e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7599312 0.963 rs10184221 chr2:213409014 G/A cg20637307 chr2:213403960 ERBB4 0.47 9.68 0.36 8.69e-21 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA trans rs7980799 0.935 rs9888363 chr12:33529288 A/G cg26384229 chr12:38710491 ALG10B -0.4 -8.4 -0.32 2.82e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg13010199 chr12:38710504 ALG10B -0.41 -8.76 -0.33 1.74e-17 Morning vs. evening chronotype; BRCA trans rs9858542 0.953 rs6997 chr3:49453834 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.02 -0.34 2.24e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6952809 0.516 rs6952959 chr7:2440722 C/T cg05083358 chr7:2394359 EIF3B -0.51 -8.04 -0.3 4.52e-15 Multiple sclerosis; BRCA cis rs698833 0.819 rs12053381 chr2:44570804 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.55 11.5 0.41 6.06e-28 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg18479299 chr3:125709523 NA -0.56 -8.74 -0.33 2.06e-17 Blood pressure (smoking interaction); BRCA cis rs7582180 0.663 rs2309800 chr2:100992086 C/T cg14675211 chr2:100938903 LONRF2 0.43 9.54 0.35 2.92e-20 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg11266682 chr4:10021025 SLC2A9 0.5 13.18 0.46 3.04e-35 Bone mineral density; BRCA cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06544989 chr22:39130855 UNC84B 0.35 7.95 0.3 8.74e-15 Menopause (age at onset); BRCA cis rs908922 0.651 rs564107 chr1:152519295 C/T cg20991723 chr1:152506922 NA 0.37 8.32 0.31 5.36e-16 Hair morphology; BRCA cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg07636037 chr3:49044803 WDR6 0.87 23.54 0.68 1.05e-88 Parkinson's disease; BRCA cis rs2073300 1.000 rs74273799 chr20:23444492 T/C cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs514406 0.505 rs448788 chr1:53161620 A/G cg16325326 chr1:53192061 ZYG11B -0.9 -24.67 -0.7 6.58e-95 Monocyte count; BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg03188948 chr7:1209495 NA 0.45 8.23 0.31 1.06e-15 Longevity;Endometriosis; BRCA cis rs2580764 0.540 rs10210840 chr2:55226009 G/A cg09592903 chr2:55203963 RTN4 -0.33 -8.67 -0.32 3.46e-17 Mean platelet volume; BRCA cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg00409905 chr10:38381863 ZNF37A -0.54 -11.55 -0.42 3.73e-28 Extrinsic epigenetic age acceleration; BRCA cis rs3820928 0.874 rs2229813 chr2:227892720 C/T cg11843606 chr2:227700838 RHBDD1 -0.35 -7.92 -0.3 1.06e-14 Pulmonary function; BRCA trans rs11252926 0.624 rs7085214 chr10:468133 A/G cg00953403 chr17:74099816 EXOC7 0.46 8.63 0.32 4.88e-17 Psychosis in Alzheimer's disease; BRCA trans rs62103177 0.810 rs62096745 chr18:77619135 A/G cg05926928 chr17:57297772 GDPD1 1.34 17.48 0.57 3.25e-56 Opioid sensitivity; BRCA cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg26384229 chr12:38710491 ALG10B -0.78 -18.18 -0.58 7.41e-60 Bladder cancer; BRCA trans rs12517041 1.000 rs10805750 chr5:23300753 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.47 -7.85 -0.3 1.72e-14 Calcium levels; BRCA trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg17830980 chr10:43048298 ZNF37B -0.56 -13.71 -0.48 1.12e-37 Extrinsic epigenetic age acceleration; BRCA cis rs2617583 0.904 rs2937639 chr5:1443728 A/G cg07151155 chr5:1473589 LPCAT1 -0.38 -8.53 -0.32 1.09e-16 Breast cancer; BRCA cis rs1395 0.744 rs7600932 chr2:27474869 G/A cg23587288 chr2:27483067 SLC30A3 -0.38 -8.84 -0.33 9.12e-18 Blood metabolite levels; BRCA cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg18876405 chr7:65276391 NA -0.53 -11.99 -0.43 5.04e-30 Calcium levels; BRCA cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg18876405 chr7:65276391 NA -0.57 -13.38 -0.47 3.53e-36 Aortic root size; BRCA trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21659725 chr3:3221576 CRBN -0.47 -11.94 -0.43 8.12e-30 Intelligence (multi-trait analysis); BRCA cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg18904891 chr8:8559673 CLDN23 0.61 11.99 0.43 5.2e-30 Obesity-related traits; BRCA cis rs12188164 0.580 rs2672755 chr5:457249 G/T cg15640734 chr5:494837 SLC9A3 0.31 7.89 0.3 1.29e-14 Cystic fibrosis severity; BRCA cis rs35995292 0.534 rs2392604 chr7:38918012 C/T cg19327137 chr7:38886074 VPS41 0.4 13.32 0.47 6.51e-36 Subjective well-being (multi-trait analysis); BRCA cis rs2645694 0.626 rs2703129 chr4:77818548 T/C cg03477792 chr4:77819574 ANKRD56 0.62 14.78 0.5 9.7e-43 Emphysema distribution in smoking; BRCA cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg25019033 chr10:957182 NA -0.41 -7.96 -0.3 7.6e-15 Eosinophil percentage of granulocytes; BRCA cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.66 -0.32 3.82e-17 Glomerular filtration rate (creatinine); BRCA cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.69 0.33 3.02e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2243480 1.000 rs9769882 chr7:65642925 T/C cg18252515 chr7:66147081 NA 1.06 15.97 0.53 1.49e-48 Diabetic kidney disease; BRCA cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg15017067 chr4:17643749 FAM184B 0.34 10.35 0.38 2.6e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs317689 0.680 rs315140 chr12:69790780 A/T cg14784868 chr12:69753453 YEATS4 0.47 9.26 0.34 3.1e-19 Response to diuretic therapy; BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26314531 chr2:26401878 FAM59B -0.66 -11.27 -0.41 5.58e-27 Gut microbiome composition (summer); BRCA cis rs17401966 1.000 rs4846210 chr1:10322153 A/G cg03954927 chr1:10346856 KIF1B 0.45 12.8 0.45 1.41e-33 Hepatocellular carcinoma; BRCA cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg13114125 chr14:105738426 BRF1 -0.49 -10.42 -0.38 1.36e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg00484396 chr16:3507460 NAT15 -0.44 -8.97 -0.33 3.34e-18 Tuberculosis; BRCA trans rs225245 0.782 rs178649 chr17:33908197 C/G cg19694781 chr19:47549865 TMEM160 -0.33 -8.02 -0.3 4.96e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.93e-19 Lymphocyte counts; BRCA cis rs561341 1.000 rs15654 chr17:30326360 A/C cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.63e-17 Hip circumference adjusted for BMI; BRCA trans rs783540 0.632 rs17356528 chr15:83305550 A/G cg18393722 chr15:85113863 UBE2QP1 -0.31 -8.5 -0.32 1.37e-16 Schizophrenia; BRCA cis rs9503598 0.636 rs6596974 chr6:3465833 C/T cg00476032 chr6:3446245 SLC22A23 0.38 9.32 0.35 1.9e-19 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg25019033 chr10:957182 NA -0.41 -7.99 -0.3 6.46e-15 Eosinophil percentage of granulocytes; BRCA cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.6 13.62 0.47 2.84e-37 Breast cancer; BRCA cis rs2635047 1.000 rs2277717 chr18:44702718 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 8.2 0.31 1.31e-15 Educational attainment; BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg11584989 chr19:19387371 SF4 -0.31 -8.11 -0.31 2.5e-15 Tonsillectomy; BRCA cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.41 -9.33 -0.35 1.72e-19 Alzheimer's disease (late onset); BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg08888203 chr3:10149979 C3orf24 0.61 13.03 0.46 1.34e-34 Alzheimer's disease; BRCA cis rs7756236 0.521 rs9394368 chr6:36630525 C/G cg08179530 chr6:36648295 CDKN1A -0.55 -12.47 -0.44 4.29e-32 QRS duration; BRCA cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg03517284 chr6:25882590 NA -0.53 -12.2 -0.43 6.33e-31 Blood metabolite levels; BRCA cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg18904891 chr8:8559673 CLDN23 0.65 13.06 0.46 1.02e-34 Obesity-related traits; BRCA trans rs9944715 0.911 rs9956574 chr18:43782203 C/T cg01718231 chr17:29326311 RNF135 -0.46 -8.96 -0.33 3.62e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg02544614 chr20:61657117 NA 0.29 8.2 0.31 1.34e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg00530320 chr1:46809349 NSUN4 0.48 9.78 0.36 3.87e-21 Menopause (age at onset); BRCA cis rs1008375 0.966 rs3775925 chr4:17588437 A/G cg15017067 chr4:17643749 FAM184B 0.35 10.79 0.39 4.74e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7786808 0.552 rs35809824 chr7:158185067 C/T cg02030672 chr11:45687055 CHST1 0.45 9.52 0.35 3.58e-20 Obesity-related traits; BRCA cis rs427394 0.659 rs419128 chr5:6739791 G/A cg10857441 chr5:6722123 POLS -0.32 -10.19 -0.37 1.09e-22 Menopause (age at onset); BRCA cis rs7098414 0.530 rs4146515 chr10:82116602 G/A cg01528321 chr10:82214614 TSPAN14 0.63 13.23 0.46 1.65e-35 Post bronchodilator FEV1; BRCA cis rs4363385 0.755 rs1933382 chr1:153003295 G/T cg24667326 chr1:152973720 SPRR3 0.31 8.35 0.31 4.19e-16 Inflammatory skin disease; BRCA cis rs3099143 1.000 rs3099137 chr15:77123626 G/A cg21673338 chr15:77095150 SCAPER -0.53 -9.51 -0.35 3.9e-20 Recalcitrant atopic dermatitis; BRCA cis rs9324022 0.929 rs12888043 chr14:101170436 A/G cg18089426 chr14:101175970 NA -0.63 -11.93 -0.43 8.85e-30 Plateletcrit; BRCA trans rs17685 0.753 rs4732542 chr7:75663203 A/G cg19862616 chr7:65841803 NCRNA00174 0.84 27.77 0.74 6.05e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7020830 0.898 rs12555207 chr9:37315476 C/T cg14294708 chr9:37120828 ZCCHC7 1.11 34.75 0.81 2.19e-149 Schizophrenia; BRCA cis rs4642101 0.855 rs9873475 chr3:12845422 A/G cg24848339 chr3:12840334 CAND2 0.41 10.56 0.39 3.86e-24 QRS complex (12-leadsum); BRCA cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.51 0.71 1.6e-99 Chronic sinus infection; BRCA cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.99 14.86 0.51 4.23e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg12927641 chr6:109611667 NA 0.4 10.41 0.38 1.48e-23 Reticulocyte fraction of red cells; BRCA cis rs10267417 0.603 rs6976553 chr7:19869113 T/C cg05791153 chr7:19748676 TWISTNB 0.5 9.69 0.36 8.11e-21 Night sleep phenotypes; BRCA cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg16339924 chr4:17578868 LAP3 0.66 16.58 0.55 1.36e-51 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg20701182 chr2:24300061 SF3B14 0.7 13.17 0.46 3.29e-35 Lymphocyte counts; BRCA cis rs9381107 0.505 rs13208500 chr6:9479707 T/C cg14735645 chr6:9486422 NA -0.44 -8.61 -0.32 5.52e-17 Nonsyndromic cleft lip with cleft palate; BRCA cis rs10267417 0.657 rs7800274 chr7:19871184 G/T cg05791153 chr7:19748676 TWISTNB 0.5 9.51 0.35 3.92e-20 Night sleep phenotypes; BRCA cis rs6714710 0.603 rs11691494 chr2:98419726 T/A cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.86e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs568617 0.716 rs111953392 chr11:65595697 G/A cg04055107 chr11:65626734 MUS81;CFL1 0.66 9.56 0.35 2.57e-20 Crohn's disease; BRCA cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg16049864 chr8:95962084 TP53INP1 -0.44 -10.85 -0.39 2.79e-25 Type 2 diabetes; BRCA cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg24642439 chr20:33292090 TP53INP2 0.65 14.62 0.5 5.44e-42 Coronary artery disease; BRCA cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg23992470 chr4:843637 GAK 0.5 8.09 0.3 3.05e-15 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs17253792 0.822 rs80085988 chr14:56096173 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg06671706 chr8:8559999 CLDN23 0.43 8.36 0.31 3.99e-16 Obesity-related traits; BRCA cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg16322792 chr1:120165303 ZNF697 -0.57 -15.02 -0.51 7.17e-44 Systemic lupus erythematosus; BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.04 -0.3 4.35e-15 Total body bone mineral density; BRCA cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg00677455 chr12:58241039 CTDSP2 0.63 14.18 0.49 7.02e-40 Multiple sclerosis; BRCA cis rs73001065 0.818 rs10500212 chr19:19723215 C/T cg03709012 chr19:19516395 GATAD2A 0.75 9.37 0.35 1.18e-19 LDL cholesterol; BRCA cis rs757110 0.745 rs2074311 chr11:17421860 A/G cg15432903 chr11:17409602 KCNJ11 0.56 11.81 0.42 2.92e-29 Type 2 diabetes; BRCA cis rs7714584 1.000 rs4579248 chr5:150268151 C/T cg22134413 chr5:150180641 NA 0.8 10.95 0.4 1.09e-25 Crohn's disease; BRCA cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg00814883 chr7:100076585 TSC22D4 -0.54 -11.65 -0.42 1.4e-28 Platelet count; BRCA cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg08601574 chr20:25228251 PYGB -0.37 -8.91 -0.33 5.35e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg27170947 chr2:26402098 FAM59B -0.81 -13.05 -0.46 1.1e-34 Gut microbiome composition (summer); BRCA cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.58 15.75 0.53 1.89e-47 Colorectal cancer; BRCA cis rs758324 0.947 rs476428 chr5:131301615 G/A cg06307176 chr5:131281290 NA -0.54 -10.34 -0.38 2.75e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.95 0.3 8.44e-15 Aortic root size; BRCA cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg12463550 chr7:65579703 CRCP -0.37 -8.01 -0.3 5.46e-15 Aortic root size; BRCA trans rs11098499 0.722 rs10025925 chr4:120271744 A/T cg25214090 chr10:38739885 LOC399744 0.45 10.62 0.39 2.18e-24 Corneal astigmatism; BRCA cis rs28595532 0.920 rs10001115 chr4:119781867 A/C cg14228332 chr4:119757509 SEC24D 0.71 8.46 0.32 1.81e-16 Cannabis dependence symptom count; BRCA cis rs4240897 0.935 rs3766744 chr1:12043717 G/A cg13216073 chr1:12042593 MFN2 0.56 13.65 0.48 2.02e-37 Tuberculosis; BRCA cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 11.38 0.41 1.9e-27 Multiple sclerosis; BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg08470875 chr2:26401718 FAM59B 0.6 7.95 0.3 8.26e-15 Gut microbiome composition (summer); BRCA cis rs11249608 0.548 rs2132672 chr5:178457742 A/C cg21905437 chr5:178450457 ZNF879 0.54 11.14 0.4 1.81e-26 Pubertal anthropometrics; BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.59 -0.32 6.54e-17 Total body bone mineral density; BRCA trans rs61931739 0.534 rs11053047 chr12:34161084 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.7 0.36 7.46e-21 Morning vs. evening chronotype; BRCA trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.91 -0.56 2.79e-53 Intelligence (multi-trait analysis); BRCA trans rs853679 0.824 rs1321505 chr6:28052823 A/C cg01620082 chr3:125678407 NA -0.59 -8.22 -0.31 1.14e-15 Depression; BRCA cis rs4891159 0.548 rs12454625 chr18:74128751 A/G cg24786174 chr18:74118243 ZNF516 0.84 25.35 0.71 1.24e-98 Longevity; BRCA cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg21770322 chr7:97807741 LMTK2 0.43 11.35 0.41 2.57e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.541 rs523937 chr2:219437596 G/C cg02176678 chr2:219576539 TTLL4 0.46 12.16 0.43 9.47e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg26597838 chr10:835615 NA 1.01 18.11 0.58 1.87e-59 Eosinophil percentage of granulocytes; BRCA cis rs9393692 1.000 rs2393593 chr6:26285683 T/C cg13736514 chr6:26305472 NA -0.4 -12.69 -0.45 4.75e-33 Educational attainment; BRCA cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg11663144 chr21:46675770 NA -0.55 -12.95 -0.46 3.3e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs16858210 0.607 rs57874587 chr3:183584749 C/T cg25686905 chr3:183603175 PARL -0.39 -8.5 -0.32 1.34e-16 Menopause (age at onset); BRCA cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg21782813 chr7:2030301 MAD1L1 0.39 10.01 0.37 5.01e-22 Bipolar disorder and schizophrenia; BRCA cis rs11229555 0.574 rs12272310 chr11:58186462 A/C cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.23e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9309473 0.607 rs11686504 chr2:73579812 T/C cg20560298 chr2:73613845 ALMS1 -0.42 -10.94 -0.4 1.15e-25 Metabolite levels; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg13047869 chr3:10149882 C3orf24 0.59 12.27 0.44 3.13e-31 Alzheimer's disease; BRCA cis rs9287719 0.967 rs715246 chr2:10736355 G/A cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs9318086 0.935 rs2025701 chr13:24440581 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.3 8.77 0.33 1.57e-17 Myopia (pathological); BRCA cis rs875971 1.000 rs697970 chr7:65560052 G/C cg18876405 chr7:65276391 NA -0.57 -13.19 -0.46 2.55e-35 Aortic root size; BRCA cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg25358565 chr5:93447407 FAM172A -1.16 -18.49 -0.59 1.87e-61 Diabetic retinopathy; BRCA cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.91 0.3 1.15e-14 Parkinson's disease; BRCA cis rs7255436 0.965 rs7254882 chr19:8453822 A/G cg10174797 chr19:8464628 RAB11B 0.35 9.07 0.34 1.47e-18 HDL cholesterol; BRCA cis rs10193935 0.901 rs62142639 chr2:42600019 C/G cg27598129 chr2:42591480 NA -0.87 -14.44 -0.5 4.05e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg15017067 chr4:17643749 FAM184B 0.28 8.41 0.32 2.61e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2370759 1.000 rs76467481 chr10:32610740 T/G cg18270830 chr10:32634957 EPC1 0.58 9.97 0.37 7.26e-22 Sexual dysfunction (female); BRCA cis rs9341808 0.718 rs2179842 chr6:80979053 T/C cg08355045 chr6:80787529 NA 0.37 9.65 0.36 1.16e-20 Sitting height ratio; BRCA cis rs11674184 0.525 rs4669755 chr2:11748585 A/C cg07314298 chr2:11723111 GREB1 0.62 12.52 0.44 2.51e-32 Endometriosis; BRCA cis rs6840360 0.615 rs3828546 chr4:152679816 A/G cg22705602 chr4:152727874 NA -0.38 -10.4 -0.38 1.68e-23 Intelligence (multi-trait analysis); BRCA cis rs586533 0.837 rs670426 chr11:99499308 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs10838687 0.736 rs3781619 chr11:47255317 C/T cg25783544 chr11:47291846 MADD 0.43 7.93 0.3 1e-14 Proinsulin levels; BRCA cis rs897984 0.520 rs4889622 chr16:30870957 A/G cg02466173 chr16:30829666 NA 0.46 9.35 0.35 1.43e-19 Dementia with Lewy bodies; BRCA cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg02733842 chr7:1102375 C7orf50 -0.65 -12.04 -0.43 3.25e-30 Bronchopulmonary dysplasia; BRCA cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg03517284 chr6:25882590 NA -0.38 -8.29 -0.31 6.48e-16 Intelligence (multi-trait analysis); BRCA cis rs12478296 0.792 rs6740738 chr2:243007368 A/C cg06360820 chr2:242988706 NA -0.9 -16.91 -0.56 2.63e-53 Obesity-related traits; BRCA trans rs7824557 0.767 rs10104728 chr8:11171300 A/G cg08975724 chr8:8085496 FLJ10661 0.43 7.92 0.3 1.04e-14 Retinal vascular caliber; BRCA cis rs9814567 1.000 rs13322305 chr3:134310791 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.863 rs1010740 chr4:120463409 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.36 -8.22 -0.31 1.16e-15 Corneal astigmatism; BRCA trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg03929089 chr4:120376271 NA -0.68 -13.54 -0.47 6.36e-37 Coronary artery disease; BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.77 -13.25 -0.46 1.46e-35 Platelet count; BRCA trans rs783540 1.000 rs11631963 chr15:83318202 T/C cg18393722 chr15:85113863 UBE2QP1 0.26 8.28 0.31 6.99e-16 Schizophrenia; BRCA cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg11822812 chr5:140052017 DND1 -0.3 -8.22 -0.31 1.16e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg13256891 chr4:100009986 ADH5 0.52 9.79 0.36 3.48e-21 Alcohol dependence; BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg25036284 chr2:26402008 FAM59B -0.95 -16.07 -0.54 4.82e-49 Gut microbiome composition (summer); BRCA cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.19 0.49 6.12e-40 Motion sickness; BRCA cis rs459482 1.000 rs464783 chr21:42796480 A/G cg14166395 chr21:42792516 MX1 -0.52 -12.05 -0.43 2.84e-30 IgG glycosylation; BRCA cis rs4671400 0.571 rs4672428 chr2:61478497 C/T cg15711740 chr2:61764176 XPO1 0.44 8.77 0.33 1.56e-17 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs1198430 1.000 rs1198432 chr1:23756155 C/T cg19827787 chr1:23763612 ASAP3 -0.36 -9.61 -0.36 1.7e-20 Total cholesterol levels; BRCA cis rs7267979 1.000 rs2258884 chr20:25279539 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.2e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9457247 0.765 rs9457251 chr6:167426707 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -10.05 -0.37 3.79e-22 Crohn's disease; BRCA cis rs909002 0.830 rs10914461 chr1:32113217 G/A cg11573219 chr1:32083031 HCRTR1 0.29 9.18 0.34 6.11e-19 Intelligence (multi-trait analysis); BRCA cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.2 0.37 9.63e-23 Aortic root size; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.5 -0.59 1.6e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs870825 0.616 rs7683799 chr4:185632164 T/C cg04058563 chr4:185651563 MLF1IP 0.76 16.91 0.56 2.63e-53 Blood protein levels; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg08888203 chr3:10149979 C3orf24 0.57 11.96 0.43 6.77e-30 Alzheimer's disease; BRCA cis rs12618769 0.597 rs4851133 chr2:99050519 T/C cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.71e-15 Bipolar disorder; BRCA cis rs2841233 0.692 rs2028416 chr14:105348552 C/T cg16576083 chr14:105354267 KIAA0284 0.44 11.43 0.41 1.22e-27 IgG glycosylation; BRCA cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.91 0.3 1.16e-14 Axial length; BRCA cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.61 -12.91 -0.45 4.86e-34 Personality dimensions; BRCA cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.99 0.37 6.16e-22 Bipolar disorder; BRCA cis rs7633857 0.512 rs1374787 chr3:160700144 C/T cg03342759 chr3:160939853 NMD3 -0.54 -11.43 -0.41 1.17e-27 Educational attainment (years of education); BRCA cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg05890377 chr2:74357713 NA 0.52 11.11 0.4 2.49e-26 Gestational age at birth (maternal effect); BRCA cis rs10504073 0.584 rs4873300 chr8:49902201 C/G cg00325661 chr8:49890786 NA 0.54 15.56 0.52 1.52e-46 Blood metabolite ratios; BRCA cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs514406 0.708 rs480299 chr1:53320274 G/T cg24675658 chr1:53192096 ZYG11B -0.71 -15.9 -0.53 3.3e-48 Monocyte count; BRCA trans rs3857536 0.642 rs7755840 chr6:66891913 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs7254827 0.826 rs12978850 chr19:17222753 C/T cg19418318 chr19:17219073 MYO9B -0.51 -10.29 -0.38 4.28e-23 Mean platelet volume; BRCA cis rs654950 1.000 rs621680 chr1:41984584 C/T cg06885757 chr1:42089581 HIVEP3 -0.23 -8.04 -0.3 4.5e-15 Airway imaging phenotypes; BRCA cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg17143192 chr8:8559678 CLDN23 0.57 11.1 0.4 2.58e-26 Obesity-related traits; BRCA cis rs6684428 0.706 rs10888942 chr1:56335432 C/G cg11651538 chr1:56320950 NA -0.49 -8.47 -0.32 1.69e-16 Airflow obstruction; BRCA cis rs858239 0.539 rs2178139 chr7:23191636 A/G cg23682824 chr7:23144976 KLHL7 0.41 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 17.25 0.56 4.8e-55 Alzheimer's disease; BRCA cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg15704280 chr7:45808275 SEPT13 -0.76 -16.78 -0.55 1.18e-52 Coronary artery disease; BRCA cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11890956 chr21:40555474 PSMG1 1.09 33.76 0.8 3.49e-144 Cognitive function; BRCA cis rs782590 0.967 rs10496050 chr2:55806313 C/T cg18811423 chr2:55921094 PNPT1 0.71 23.15 0.68 1.47e-86 Metabolic syndrome; BRCA cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg23018236 chr17:30244563 NA -0.68 -10.6 -0.39 2.7e-24 Hip circumference adjusted for BMI; BRCA cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.19 0.4 1.15e-26 Rheumatoid arthritis; BRCA cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.74e-21 Colorectal cancer; BRCA cis rs7254827 0.737 rs62126055 chr19:17166344 C/T cg19418318 chr19:17219073 MYO9B -0.48 -10.05 -0.37 3.52e-22 Mean platelet volume; BRCA cis rs2832077 0.943 rs11701777 chr21:30155828 T/C cg08807101 chr21:30365312 RNF160 -0.45 -7.84 -0.3 1.96e-14 Cognitive test performance; BRCA cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg18904891 chr8:8559673 CLDN23 0.65 13.06 0.46 1.04e-34 Obesity-related traits; BRCA cis rs2455799 0.574 rs2470534 chr3:15701054 C/G cg16303742 chr3:15540471 COLQ 0.36 8.74 0.33 2.1e-17 Mean platelet volume; BRCA cis rs7011049 0.722 rs11985689 chr8:53832615 G/A cg26025543 chr8:53854495 NA 0.53 9.71 0.36 7.26e-21 Systolic blood pressure; BRCA trans rs12517041 1.000 rs10805749 chr5:23300740 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.47 -7.85 -0.3 1.72e-14 Calcium levels; BRCA cis rs4074536 0.574 rs10923361 chr1:116292882 T/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 5e-17 QRS duration; BRCA trans rs12517041 1.000 rs10052113 chr5:23287871 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs72781680 0.716 rs72788284 chr2:24097539 A/G cg08917208 chr2:24149416 ATAD2B 0.61 10.36 0.38 2.39e-23 Lymphocyte counts; BRCA cis rs17401966 0.898 rs12117635 chr1:10317445 C/T cg03954927 chr1:10346856 KIF1B 0.4 12.63 0.45 8.07e-33 Hepatocellular carcinoma; BRCA cis rs12618769 0.597 rs10496327 chr2:99066827 A/G cg10123293 chr2:99228465 UNC50 0.41 7.9 0.3 1.21e-14 Bipolar disorder; BRCA cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs11920090 0.800 rs12486657 chr3:170738349 T/A cg09710316 chr3:170744871 SLC2A2 0.47 8.75 0.33 1.86e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg12769354 chr4:140004069 ELF2 0.33 8.83 0.33 1.04e-17 Mosquito bite size; BRCA cis rs1891275 0.515 rs6583784 chr10:93491576 A/G cg07889827 chr10:93443413 NA 0.41 11.1 0.4 2.68e-26 Intelligence (multi-trait analysis); BRCA cis rs2011503 0.882 rs1064395 chr19:19361735 C/T cg11584989 chr19:19387371 SF4 0.54 12.05 0.43 2.74e-30 Bipolar disorder; BRCA cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.02 0.43 3.79e-30 Multiple sclerosis; BRCA trans rs7615952 0.551 rs12695470 chr3:125635718 C/A cg07211511 chr3:129823064 LOC729375 -1.05 -18.4 -0.59 5.22e-61 Blood pressure (smoking interaction); BRCA cis rs7833986 0.501 rs72653957 chr8:56990048 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.25 0.46 1.44e-35 Height; BRCA cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.29 0.31 6.67e-16 Breast cancer; BRCA cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg02733842 chr7:1102375 C7orf50 -0.73 -12.6 -0.45 1.17e-32 Bronchopulmonary dysplasia; BRCA cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg16405210 chr4:1374714 KIAA1530 -0.94 -20.9 -0.64 2.54e-74 Longevity; BRCA cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg17410650 chr12:54324560 NA -0.54 -15.55 -0.52 1.76e-46 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); BRCA cis rs17095355 1.000 rs55897175 chr10:111699190 C/T cg00817464 chr10:111662876 XPNPEP1 -0.4 -10.46 -0.38 9.56e-24 Biliary atresia; BRCA cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg11584989 chr19:19387371 SF4 0.63 13.44 0.47 1.83e-36 Bipolar disorder; BRCA cis rs2288073 0.965 rs72789923 chr2:24394504 A/C cg26838691 chr2:24397539 C2orf84 -0.54 -9.54 -0.35 2.89e-20 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg05347473 chr6:146136440 FBXO30 -0.41 -8.05 -0.3 3.93e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs4596713 0.507 rs2275428 chr9:71792582 A/T cg16512924 chr15:28394682 HERC2 0.45 10.8 0.39 4.51e-25 Headache; BRCA cis rs1451375 0.698 rs56233242 chr7:50634053 C/A cg18232548 chr7:50535776 DDC 0.4 9.34 0.35 1.59e-19 Malaria; BRCA cis rs11711311 1.000 rs9828449 chr3:113518602 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.74 -0.36 5.24e-21 IgG glycosylation; BRCA cis rs2281845 0.507 rs1536127 chr1:201086894 C/A cg06714761 chr1:201096289 NA 0.56 13.95 0.48 8.58e-39 Permanent tooth development; BRCA cis rs1580019 0.587 rs7806113 chr7:32553084 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.29 0.31 6.78e-16 Cognitive ability; BRCA cis rs7582720 0.945 rs2351524 chr2:203880992 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.74 -12.26 -0.44 3.61e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs698833 0.518 rs4953085 chr2:44554724 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.4 0.32 2.92e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs765787 0.530 rs1706764 chr15:45524256 T/A cg24006582 chr15:45444508 DUOX1 -0.53 -10.93 -0.4 1.34e-25 Uric acid levels; BRCA cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg08564027 chr20:61660810 NA 0.85 22.91 0.67 2.99e-85 Prostate cancer (SNP x SNP interaction); BRCA trans rs3780486 0.846 rs10124479 chr9:33136233 T/G cg20290983 chr6:43655470 MRPS18A 1.11 40.51 0.85 1.18e-178 IgG glycosylation; BRCA cis rs7246657 0.722 rs2972437 chr19:38210511 G/T cg23950597 chr19:37808831 NA -0.49 -8.45 -0.32 1.96e-16 Coronary artery calcification; BRCA cis rs9868809 0.881 rs2276850 chr3:48669648 G/A cg00383909 chr3:49044727 WDR6 0.55 8.38 0.31 3.29e-16 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg04511125 chr2:88470314 THNSL2 -0.52 -10.73 -0.39 8.43e-25 Response to metformin (IC50); BRCA cis rs597539 0.652 rs559032 chr11:68710847 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 18.45 0.59 3e-61 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.49 -0.44 3.3e-32 Developmental language disorder (linguistic errors); BRCA cis rs4363385 0.669 rs2937264 chr1:153011026 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg11707556 chr5:10655725 ANKRD33B -0.41 -8.87 -0.33 7.31e-18 Coronary artery disease; BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg16606324 chr3:10149918 C3orf24 -0.52 -10.57 -0.39 3.4e-24 Alzheimer's disease; BRCA cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg00990874 chr7:1149470 C7orf50 -0.52 -9.41 -0.35 8.74e-20 Bronchopulmonary dysplasia; BRCA cis rs9859260 0.744 rs419059 chr3:195782184 C/T cg12923728 chr3:195709715 SDHAP1 0.38 7.85 0.3 1.72e-14 Mean corpuscular volume; BRCA cis rs6831352 0.842 rs1230156 chr4:99989626 C/T cg12011299 chr4:100065546 ADH4 0.48 10.68 0.39 1.28e-24 Alcohol dependence; BRCA cis rs16867321 0.694 rs4666853 chr2:181439671 C/T cg23363182 chr2:181467187 NA 0.46 10.17 0.37 1.24e-22 Obesity; BRCA cis rs10911251 0.527 rs1537520 chr1:183084229 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 16.87 0.56 4.55e-53 Colorectal cancer; BRCA cis rs3784262 0.631 rs4646584 chr15:58305402 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.07 -0.37 3.07e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.52 8.68 0.32 3.27e-17 Lung function (FEV1/FVC); BRCA cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.57 11.69 0.42 9.48e-29 Hip circumference adjusted for BMI; BRCA cis rs11603020 0.904 rs4926 chr11:57381989 G/A cg19752551 chr11:57585705 CTNND1 -0.42 -9.63 -0.36 1.41e-20 Blood protein levels; BRCA cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg16479474 chr6:28041457 NA 0.42 7.81 0.3 2.41e-14 Depression; BRCA cis rs7824557 0.767 rs6985146 chr8:11170721 A/C cg21775007 chr8:11205619 TDH 0.55 10.58 0.39 3.22e-24 Retinal vascular caliber; BRCA cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg18514922 chr2:160761262 LY75 -0.38 -8.74 -0.33 2e-17 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12497850 0.865 rs13072911 chr3:48962128 T/G cg06212747 chr3:49208901 KLHDC8B 0.47 9.75 0.36 5.12e-21 Parkinson's disease; BRCA cis rs796364 0.951 rs7586320 chr2:201068209 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 8.36 0.31 3.97e-16 Schizophrenia; BRCA cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg21856205 chr7:94953877 PON1 -0.37 -8.17 -0.31 1.68e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs698813 0.674 rs4953080 chr2:44500849 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.68 0.32 3.24e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs10752881 1.000 rs12133714 chr1:182988252 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.24e-52 Colorectal cancer; BRCA cis rs858239 0.539 rs4504540 chr7:23186198 C/G cg23682824 chr7:23144976 KLHL7 0.41 10.65 0.39 1.72e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.28 0.41 4.81e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg07308232 chr7:1071921 C7orf50 0.52 11.07 0.4 3.63e-26 Longevity;Endometriosis; BRCA trans rs7279771 0.736 rs41315475 chr21:35884633 G/A cg03797705 chr17:79604227 NPLOC4 -0.36 -7.89 -0.3 1.34e-14 Cancer; BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.61 9.67 0.36 9.67e-21 Renal function-related traits (BUN); BRCA cis rs898097 0.585 rs9893200 chr17:80893028 A/C cg15664640 chr17:80829946 TBCD 0.4 10.74 0.39 7.73e-25 Breast cancer; BRCA cis rs10851411 0.697 rs11630625 chr15:42819175 A/T cg21293051 chr15:42870591 STARD9 0.52 8.61 0.32 5.53e-17 Glucose homeostasis traits; BRCA cis rs6089584 0.507 rs6061999 chr20:60637429 G/A cg13770153 chr20:60521292 NA -0.35 -8.19 -0.31 1.46e-15 Body mass index; BRCA cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg05890377 chr2:74357713 NA 0.51 12.01 0.43 4.38e-30 Gestational age at birth (maternal effect); BRCA cis rs71636778 0.596 rs2095637 chr1:27232845 A/G cg12203394 chr1:27248618 NUDC 0.6 9.46 0.35 5.7e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.5 -0.44 2.98e-32 Bipolar disorder; BRCA cis rs523522 0.923 rs10774553 chr12:120954984 T/C cg12219531 chr12:120966889 COQ5 0.55 11.44 0.41 1.11e-27 High light scatter reticulocyte count; BRCA cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg03433033 chr1:76189801 ACADM 0.76 17.02 0.56 7.81e-54 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs769267 0.965 rs13964 chr19:19468710 C/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.84 -0.36 2.3e-21 Tonsillectomy; BRCA cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg24829409 chr8:58192753 C8orf71 -0.43 -8.64 -0.32 4.64e-17 Developmental language disorder (linguistic errors); BRCA cis rs4073582 0.595 rs555360 chr11:65960061 T/C cg16950941 chr11:66035639 RAB1B -0.4 -11.2 -0.41 9.96e-27 Gout; BRCA cis rs2839186 0.616 rs4819213 chr21:47619300 G/A cg12379764 chr21:47803548 PCNT 0.39 8.56 0.32 8.18e-17 Testicular germ cell tumor; BRCA cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.29 0.34 2.48e-19 Rheumatoid arthritis; BRCA cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.76e-21 Alcohol dependence; BRCA cis rs7607369 0.618 rs62193298 chr2:219655211 T/G cg02176678 chr2:219576539 TTLL4 -0.47 -12.22 -0.44 5.01e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg15017067 chr4:17643749 FAM184B 0.3 8.34 0.31 4.42e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs350251 0.899 rs350285 chr16:12228735 G/A cg06014057 chr16:12226852 SNX29 0.3 8.08 0.3 3.15e-15 Intelligence (multi-trait analysis); BRCA trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg11707556 chr5:10655725 ANKRD33B 0.6 16.04 0.54 6.4e-49 Height; BRCA cis rs2599510 0.840 rs466146 chr2:32539236 A/C cg02381751 chr2:32503542 YIPF4 0.39 8.08 0.3 3.22e-15 Interleukin-18 levels; BRCA cis rs55665837 1.000 rs7121171 chr11:14446420 A/G cg19336497 chr11:14380999 RRAS2 -0.36 -9.32 -0.35 1.82e-19 Vitamin D levels; BRCA cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg24011408 chr12:48396354 COL2A1 0.55 9.26 0.34 3.07e-19 Lung cancer; BRCA cis rs920590 0.758 rs1817836 chr8:19664852 T/C cg03894339 chr8:19674705 INTS10 0.44 8.72 0.33 2.4e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs6942756 0.806 rs9641846 chr7:128873679 G/A cg02491457 chr7:128862824 NA 0.59 12.91 0.45 4.84e-34 White matter hyperintensity burden; BRCA cis rs12458462 0.787 rs56006341 chr18:77439844 G/T cg11879182 chr18:77439856 CTDP1 0.64 13.9 0.48 1.38e-38 Monocyte count; BRCA cis rs7647973 1.000 rs6446275 chr3:49466871 A/G cg07636037 chr3:49044803 WDR6 -0.75 -16.19 -0.54 1.2e-49 Menarche (age at onset); BRCA cis rs11792861 0.926 rs2271878 chr9:111868885 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.05 0.3 3.95e-15 Menarche (age at onset); BRCA cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg11266682 chr4:10021025 SLC2A9 0.4 10.58 0.39 3.1e-24 Bone mineral density; BRCA cis rs7011049 1.000 rs72640865 chr8:53842471 C/T cg26025543 chr8:53854495 NA 0.53 9.13 0.34 8.77e-19 Systolic blood pressure; BRCA cis rs921968 0.541 rs4674314 chr2:219423520 A/G cg10223061 chr2:219282414 VIL1 0.32 9.18 0.34 6.07e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs7267979 0.966 rs2261790 chr20:25262789 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11098499 0.697 rs28655325 chr4:120372999 A/G cg09307838 chr4:120376055 NA 0.74 16.05 0.54 5.6e-49 Corneal astigmatism; BRCA cis rs3106136 0.546 rs7685121 chr4:95175682 G/A cg11021082 chr4:95130006 SMARCAD1 -0.45 -10.3 -0.38 3.91e-23 Capecitabine sensitivity; BRCA cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg24642439 chr20:33292090 TP53INP2 0.56 12.27 0.44 3.24e-31 Coronary artery disease; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg04013093 chr6:42928303 GNMT -0.29 -9.19 -0.34 5.55e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg17372223 chr3:52568218 NT5DC2 0.34 7.84 0.3 1.96e-14 Electroencephalogram traits; BRCA trans rs61931739 0.534 rs11053020 chr12:34111092 C/G cg26384229 chr12:38710491 ALG10B 0.66 13.93 0.48 1.04e-38 Morning vs. evening chronotype; BRCA cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg03806693 chr22:41940476 POLR3H 0.92 16.99 0.56 1.11e-53 Vitiligo; BRCA cis rs9837602 1.000 rs923471 chr3:99757853 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.58 10.39 0.38 1.8e-23 Breast cancer; BRCA cis rs17095355 0.818 rs56367935 chr10:111783266 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -9.66 -0.36 1.07e-20 Biliary atresia; BRCA cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 8.26e-19 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg04944784 chr2:26401820 FAM59B -0.66 -11.21 -0.41 9.53e-27 Gut microbiome composition (summer); BRCA cis rs7737355 1.000 rs9327608 chr5:130650134 G/A cg06307176 chr5:131281290 NA 0.45 8.81 0.33 1.15e-17 Life satisfaction; BRCA cis rs34779708 0.931 rs4934533 chr10:35359619 A/G cg03585969 chr10:35415529 CREM 0.46 9.6 0.35 1.82e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg01877450 chr7:97915802 BRI3 -0.39 -8.87 -0.33 7.43e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs12479064 0.671 rs62155807 chr2:100076579 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.49 -9.47 -0.35 5.37e-20 Chronic sinus infection; BRCA cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg13628971 chr7:2884303 GNA12 0.4 9.02 0.34 2.15e-18 Height; BRCA cis rs12479064 0.724 rs11885942 chr2:100004165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -12.07 -0.43 2.38e-30 Chronic sinus infection; BRCA trans rs7618501 0.635 rs7635002 chr3:49989155 T/G cg21659725 chr3:3221576 CRBN 0.5 12.9 0.45 5.33e-34 Intelligence (multi-trait analysis); BRCA cis rs7944584 0.511 rs10838725 chr11:47557871 T/C cg03711944 chr11:47377212 SPI1 -0.41 -9.75 -0.36 5.1e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.34e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1451375 0.617 rs2876829 chr7:50566762 A/G cg18232548 chr7:50535776 DDC 0.42 9.12 0.34 9.32e-19 Malaria; BRCA trans rs8002861 0.664 rs1466005 chr13:44424210 T/C cg17145862 chr1:211918768 LPGAT1 0.47 10.82 0.39 3.74e-25 Leprosy; BRCA cis rs4594175 0.926 rs113095693 chr14:51600511 G/C cg23942311 chr14:51606299 NA 0.34 8.47 0.32 1.72e-16 Cancer; BRCA cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg13073564 chr4:8508604 NA -0.39 -10.7 -0.39 1.12e-24 Response to antineoplastic agents; BRCA cis rs4642101 0.561 rs4560285 chr3:12809066 G/A cg24848339 chr3:12840334 CAND2 0.33 8.5 0.32 1.33e-16 QRS complex (12-leadsum); BRCA cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg22535103 chr8:58192502 C8orf71 -0.46 -8.96 -0.33 3.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs365132 1.000 rs353493 chr5:176432585 T/C cg16309518 chr5:176445507 NA -0.51 -13.27 -0.46 1.08e-35 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs6835098 0.961 rs2877748 chr4:174102397 G/A cg27433088 chr4:174089019 GALNT7 0.34 9.21 0.34 4.71e-19 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.57 -8.16 -0.31 1.75e-15 Yeast infection; BRCA cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.49 0.35 4.33e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg24812749 chr6:127587940 RNF146 0.88 20.06 0.62 9.03e-70 Breast cancer; BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.79 13.01 0.46 1.73e-34 Platelet count; BRCA cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs113835537 0.597 rs2075792 chr11:66334556 G/A cg24851651 chr11:66362959 CCS 0.44 8.41 0.32 2.62e-16 Airway imaging phenotypes; BRCA cis rs4481887 0.927 rs6587445 chr1:248440915 A/G cg00666640 chr1:248458726 OR2T12 0.32 8.71 0.33 2.59e-17 Common traits (Other); BRCA cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg03060546 chr3:49711283 APEH 0.5 10.79 0.39 4.73e-25 Resting heart rate; BRCA cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs364477 0.762 rs9299103 chr9:1001231 G/T cg13952963 chr9:998547 NA -0.47 -8.57 -0.32 7.57e-17 Major depressive disorder; BRCA cis rs6598955 0.671 rs12142535 chr1:26589698 T/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg15704280 chr7:45808275 SEPT13 0.54 9.11 0.34 1.01e-18 Axial length; BRCA cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg13010199 chr12:38710504 ALG10B 0.41 8.54 0.32 9.72e-17 Bladder cancer; BRCA cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg16586182 chr3:47516702 SCAP -0.59 -12.98 -0.46 2.43e-34 Colorectal cancer; BRCA cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.76 0.39 6.44e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg12310025 chr6:25882481 NA -0.42 -10.48 -0.38 7.77e-24 Height; BRCA cis rs8180040 0.654 rs9837343 chr3:47177388 C/T cg16586182 chr3:47516702 SCAP -0.55 -12.21 -0.43 5.88e-31 Colorectal cancer; BRCA cis rs4363385 0.818 rs435633 chr1:153011811 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs7246967 0.673 rs7248107 chr19:22878529 G/T cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.73e-21 Developmental language disorder (linguistic errors); BRCA cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs943466 0.614 rs4711345 chr6:33730954 G/A cg25922239 chr6:33757077 LEMD2 -0.33 -8.2 -0.31 1.35e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg17971929 chr21:40555470 PSMG1 -0.62 -14.55 -0.5 1.22e-41 Cognitive function; BRCA cis rs2243480 1.000 rs316331 chr7:65604622 A/G cg18252515 chr7:66147081 NA 0.98 14.67 0.5 3.3e-42 Diabetic kidney disease; BRCA cis rs1891275 0.550 rs4933694 chr10:93499213 C/T cg07889827 chr10:93443413 NA -0.41 -11.11 -0.4 2.42e-26 Intelligence (multi-trait analysis); BRCA cis rs9527 0.571 rs4917985 chr10:104624072 C/T cg04362960 chr10:104952993 NT5C2 0.4 9.72 0.36 6.3e-21 Arsenic metabolism; BRCA cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg08219700 chr8:58056026 NA 0.45 8.09 0.3 3.01e-15 Developmental language disorder (linguistic errors); BRCA trans rs3942852 0.955 rs6485809 chr11:48112468 C/T cg15704280 chr7:45808275 SEPT13 -0.49 -8.66 -0.32 3.71e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs6545883 0.811 rs778753 chr2:61780200 T/A cg15711740 chr2:61764176 XPO1 -0.48 -11.98 -0.43 5.47e-30 Tuberculosis; BRCA cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 12.18 0.43 7.98e-31 Personality dimensions; BRCA cis rs1949733 0.523 rs16842557 chr4:8543985 C/T cg11789530 chr4:8429930 ACOX3 -0.55 -12.59 -0.45 1.26e-32 Response to antineoplastic agents; BRCA cis rs11098499 0.663 rs9996501 chr4:120238918 C/A cg09307838 chr4:120376055 NA 0.63 13.59 0.47 3.72e-37 Corneal astigmatism; BRCA cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg10645314 chr2:3704589 ALLC 0.5 9.06 0.34 1.62e-18 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs7582180 0.764 rs1530028 chr2:100927910 A/C cg14675211 chr2:100938903 LONRF2 0.5 11.42 0.41 1.35e-27 Intelligence (multi-trait analysis); BRCA cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg25554036 chr4:6271136 WFS1 0.4 9.33 0.35 1.7e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs782590 0.935 rs782606 chr2:55886602 T/C cg18811423 chr2:55921094 PNPT1 0.75 25.08 0.7 3.5e-97 Metabolic syndrome; BRCA cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg10556349 chr10:835070 NA 0.64 9.31 0.35 1.97e-19 Eosinophil percentage of granulocytes; BRCA cis rs11971779 0.680 rs4077889 chr7:139033914 A/G cg07862535 chr7:139043722 LUC7L2 0.39 10.46 0.38 9.65e-24 Diisocyanate-induced asthma; BRCA trans rs1997103 1.000 rs1997103 chr7:55395390 C/G cg20935933 chr6:143382018 AIG1 0.6 11.48 0.41 7.49e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs495337 0.786 rs6125820 chr20:48545831 T/C cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg15541040 chr2:3486749 NA -0.46 -10.21 -0.37 8.86e-23 Neurofibrillary tangles; BRCA cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg00071950 chr4:10020882 SLC2A9 0.54 13.37 0.47 3.86e-36 Bone mineral density; BRCA cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -14.13 -0.49 1.17e-39 Cognitive function; BRCA cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg18351406 chr4:77819688 ANKRD56 0.54 11.72 0.42 6.82e-29 Emphysema distribution in smoking; BRCA cis rs10463316 0.779 rs6861968 chr5:150817725 C/T cg03212797 chr5:150827313 SLC36A1 -0.44 -8.84 -0.33 9.3e-18 Metabolite levels (Pyroglutamine); BRCA cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg00012203 chr2:219082015 ARPC2 0.49 9.26 0.34 3.15e-19 Colorectal cancer; BRCA cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg27398817 chr8:82754497 SNX16 -0.37 -8.0 -0.3 5.93e-15 Diastolic blood pressure; BRCA cis rs7666738 0.606 rs4637413 chr4:99088151 A/G cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 6.87e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg24110177 chr3:50126178 RBM5 -0.55 -16.38 -0.54 1.31e-50 Body mass index; BRCA cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06022373 chr22:39101656 GTPBP1 0.7 15.93 0.53 2.26e-48 Menopause (age at onset); BRCA cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg02297831 chr4:17616191 MED28 0.36 8.36 0.31 4.03e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg03452623 chr4:187889614 NA -0.34 -10.98 -0.4 8.06e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs2197308 0.643 rs1842597 chr12:37862142 C/G cg26384229 chr12:38710491 ALG10B -0.61 -14.23 -0.49 4.04e-40 Morning vs. evening chronotype; BRCA trans rs6582630 0.502 rs11182760 chr12:38606273 A/T cg06521331 chr12:34319734 NA -0.5 -9.1 -0.34 1.16e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg24130564 chr14:104152367 KLC1 -0.37 -8.71 -0.33 2.64e-17 Body mass index; BRCA cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg06618935 chr21:46677482 NA -0.37 -7.97 -0.3 7.53e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg01483505 chr11:975446 AP2A2 0.33 9.05 0.34 1.75e-18 Alzheimer's disease (late onset); BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -12.47 -0.44 4.33e-32 Bipolar disorder and schizophrenia; BRCA cis rs11971779 0.680 rs4732373 chr7:139086535 T/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg18132916 chr6:79620363 NA -0.5 -11.48 -0.41 7.25e-28 Intelligence (multi-trait analysis); BRCA cis rs10857712 0.528 rs2265638 chr10:135217175 A/G cg00491522 chr10:135256596 NA 0.56 12.01 0.43 4.02e-30 Systemic lupus erythematosus; BRCA cis rs4664304 0.966 rs925407 chr2:160767502 A/C cg02280532 chr2:160761244 LY75 -0.4 -8.9 -0.33 5.63e-18 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6089584 0.888 rs6061405 chr20:60617033 A/G cg06108461 chr20:60628389 TAF4 -0.97 -21.81 -0.65 3.05e-79 Body mass index; BRCA cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg05623727 chr3:50126028 RBM5 -0.49 -11.97 -0.43 6.16e-30 Body mass index; BRCA cis rs1891275 0.515 rs10786010 chr10:93443773 G/A cg07889827 chr10:93443413 NA -0.44 -12.37 -0.44 1.2e-31 Intelligence (multi-trait analysis); BRCA cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg12463550 chr7:65579703 CRCP 0.38 8.12 0.31 2.38e-15 Aortic root size; BRCA cis rs10046574 0.519 rs17403948 chr7:135215169 C/T cg27474649 chr7:135195673 CNOT4 -0.64 -10.69 -0.39 1.17e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.82 0.55 8.15e-53 Axial length; BRCA trans rs11098499 0.954 rs10518331 chr4:120323595 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.28e-34 Corneal astigmatism; BRCA cis rs7246657 0.551 rs4806413 chr19:37617716 A/T cg23950597 chr19:37808831 NA -0.65 -9.68 -0.36 8.75e-21 Coronary artery calcification; BRCA trans rs208520 0.661 rs7747492 chr6:66857788 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.31 -0.64 1.47e-76 Exhaled nitric oxide output; BRCA cis rs11098499 0.954 rs3733523 chr4:120423719 C/T cg09307838 chr4:120376055 NA 0.72 15.33 0.52 2.08e-45 Corneal astigmatism; BRCA cis rs1165205 0.500 rs629835 chr6:25879330 T/C cg03517284 chr6:25882590 NA -0.78 -18.61 -0.59 4.43e-62 Urate levels; BRCA cis rs6973256 0.897 rs7776986 chr7:133345635 A/G cg07491979 chr7:133331646 EXOC4 -0.36 -8.46 -0.32 1.89e-16 Intelligence (multi-trait analysis); BRCA cis rs2243480 1.000 rs160646 chr7:65556280 C/T cg18252515 chr7:66147081 NA -1.07 -15.5 -0.52 3.05e-46 Diabetic kidney disease; BRCA trans rs11722228 0.508 rs2241472 chr4:10085902 C/G cg26043149 chr18:55253948 FECH 1.1 23.28 0.68 2.89e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg23173402 chr1:227635558 NA -0.45 -8.33 -0.31 4.89e-16 Major depressive disorder; BRCA trans rs61931739 0.570 rs7315655 chr12:33912869 G/A cg26384229 chr12:38710491 ALG10B 0.4 8.98 0.33 3.05e-18 Morning vs. evening chronotype; BRCA trans rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.01e-14 Endometrial cancer; BRCA cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg16006841 chr5:176797999 RGS14 0.58 11.7 0.42 9.01e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs9296092 0.538 rs9461879 chr6:33516907 C/T cg13560919 chr6:33536144 NA -0.85 -17.45 -0.57 4.51e-56 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2204008 0.720 rs11181343 chr12:38323616 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.57 0.39 3.6e-24 Bladder cancer; BRCA cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 26.42 0.72 1.58e-104 Chronic sinus infection; BRCA cis rs495337 0.760 rs515686 chr20:48515789 G/A cg17835207 chr20:48524531 SPATA2 -0.67 -15.9 -0.53 3.16e-48 Psoriasis; BRCA cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg21926612 chr6:163149169 PACRG;PARK2 1.05 16.21 0.54 9.29e-50 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12410462 1.000 rs12407171 chr1:227642282 G/A cg04117972 chr1:227635322 NA 0.45 8.16 0.31 1.82e-15 Major depressive disorder; BRCA cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 11.96 0.43 6.84e-30 Iron status biomarkers; BRCA trans rs11098499 0.866 rs3756156 chr4:120524841 G/A cg25214090 chr10:38739885 LOC399744 0.53 11.47 0.41 7.94e-28 Corneal astigmatism; BRCA trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.38 0.31 3.28e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg14863265 chr7:2801509 GNA12 -0.47 -10.02 -0.37 4.93e-22 Height; BRCA cis rs943466 1.000 rs12524768 chr6:33760478 G/A cg25922239 chr6:33757077 LEMD2 -0.37 -8.35 -0.31 4.17e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs1355223 0.545 rs7123029 chr11:34874815 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.04 -0.3 4.31e-15 Total body bone mineral density; BRCA cis rs9392556 0.829 rs660560 chr6:4125941 A/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -8.2 -0.31 1.3e-15 Blood metabolite levels; BRCA cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg01262667 chr19:19385393 TM6SF2 -0.41 -10.7 -0.39 1.12e-24 Tonsillectomy; BRCA cis rs11098499 0.866 rs9991221 chr4:120292107 G/C cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs877529 0.967 rs139386 chr22:39530859 T/C cg18708252 chr22:39545030 CBX7 -0.31 -7.99 -0.3 6.49e-15 Multiple myeloma; BRCA cis rs9467773 0.967 rs1535276 chr6:26520941 T/C cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.15e-20 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.14e-23 Motion sickness; BRCA cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg00071950 chr4:10020882 SLC2A9 0.66 16.77 0.55 1.48e-52 Bone mineral density; BRCA cis rs2806561 0.780 rs6650086 chr1:23338384 T/C cg19743168 chr1:23544995 NA -0.4 -9.48 -0.35 4.96e-20 Height; BRCA trans rs2197308 0.703 rs10880251 chr12:37903297 G/A cg06521331 chr12:34319734 NA -0.54 -9.73 -0.36 5.73e-21 Morning vs. evening chronotype; BRCA cis rs2625529 0.761 rs8028532 chr15:72348054 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.37 -0.57 1.23e-55 Red blood cell count; BRCA cis rs56104184 0.615 rs73061693 chr19:49399941 C/A cg21252483 chr19:49399788 TULP2 -0.51 -10.86 -0.39 2.46e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg20587970 chr11:113659929 NA -1.23 -22.49 -0.66 5.65e-83 Hip circumference adjusted for BMI; BRCA cis rs459571 0.629 rs441233 chr9:136876021 A/G cg13789015 chr9:136890014 NCRNA00094 -0.65 -13.51 -0.47 8.93e-37 Platelet distribution width; BRCA cis rs61990749 0.544 rs8003979 chr14:78211290 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.76 0.36 4.52e-21 Fibroblast growth factor basic levels; BRCA cis rs13046373 0.535 rs1911571 chr21:32031538 A/C cg14062083 chr21:31802829 KRTAP13-4 0.36 9.88 0.36 1.65e-21 HDL cholesterol; BRCA cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -9.12 -0.34 1e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg26248373 chr2:1572462 NA -0.49 -9.81 -0.36 3.02e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4819052 0.655 rs2330102 chr21:46690968 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.47 10.31 0.38 3.68e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 14.75 0.5 1.35e-42 Platelet count; BRCA cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg21252483 chr19:49399788 TULP2 -0.51 -11.08 -0.4 3.1e-26 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7617773 0.817 rs9853804 chr3:48327729 T/C cg11946769 chr3:48343235 NME6 0.63 13.47 0.47 1.45e-36 Coronary artery disease; BRCA cis rs34779708 0.931 rs11010083 chr10:35351531 C/G cg03585969 chr10:35415529 CREM 0.48 10.12 0.37 1.94e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.53 -11.37 -0.41 2.14e-27 Chronic sinus infection; BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.91 -0.45 4.55e-34 Lymphocyte counts; BRCA cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg13010199 chr12:38710504 ALG10B -0.4 -8.51 -0.32 1.27e-16 Bladder cancer; BRCA cis rs4664304 0.620 rs10929957 chr2:160716508 A/G cg01092293 chr2:160761427 LY75 0.36 8.41 0.32 2.61e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12545109 0.800 rs1467124 chr8:57418862 T/G cg09654669 chr8:57350985 NA -0.39 -8.74 -0.33 2.11e-17 Obesity-related traits; BRCA cis rs1865760 1.000 rs6910174 chr6:25904414 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 11.18 0.4 1.23e-26 Height; BRCA cis rs8077889 0.645 rs1230396 chr17:41843029 A/C cg26893861 chr17:41843967 DUSP3 -1.06 -29.82 -0.76 4.49e-123 Triglycerides; BRCA trans rs35110281 0.659 rs11702544 chr21:45091861 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.49 0.35 4.63e-20 Mean corpuscular volume; BRCA cis rs35110281 0.805 rs2838317 chr21:44991791 A/C cg01579765 chr21:45077557 HSF2BP -0.41 -11.39 -0.41 1.69e-27 Mean corpuscular volume; BRCA cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.83 0.42 2.56e-29 Hip circumference adjusted for BMI; BRCA cis rs6061231 0.837 rs6061235 chr20:60978524 C/G cg24112000 chr20:60950667 NA -0.55 -10.62 -0.39 2.35e-24 Colorectal cancer; BRCA cis rs6815814 0.950 rs56289835 chr4:38811845 G/C cg06935464 chr4:38784597 TLR10 0.51 8.2 0.31 1.32e-15 Breast cancer; BRCA cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg11742103 chr11:62369870 EML3;MTA2 0.54 13.28 0.47 1.01e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs17376456 0.825 rs6865441 chr5:93284746 G/A cg25358565 chr5:93447407 FAM172A 1.22 18.51 0.59 1.51e-61 Diabetic retinopathy; BRCA cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg05234568 chr11:5960015 NA -0.52 -10.33 -0.38 3.18e-23 DNA methylation (variation); BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg09177884 chr7:1199841 ZFAND2A -0.47 -10.13 -0.37 1.84e-22 Longevity;Endometriosis; BRCA cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.46 7.98 0.3 6.92e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg22153745 chr1:153894579 GATAD2B -0.5 -10.3 -0.38 4.2e-23 Total cholesterol levels; BRCA cis rs61931739 0.534 rs1817761 chr12:34105719 C/T cg06521331 chr12:34319734 NA -0.62 -11.18 -0.4 1.22e-26 Morning vs. evening chronotype; BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg20607798 chr8:58055168 NA 0.53 8.3 0.31 6.13e-16 Developmental language disorder (linguistic errors); BRCA cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.14 0.46 4.34e-35 Bipolar disorder; BRCA cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg08601574 chr20:25228251 PYGB -0.34 -8.04 -0.3 4.42e-15 Liver enzyme levels (alkaline phosphatase); BRCA trans rs2204008 0.748 rs8186658 chr12:38301461 A/C cg06521331 chr12:34319734 NA -0.47 -9.1 -0.34 1.12e-18 Bladder cancer; BRCA cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg01283332 chr5:1856932 NA -0.33 -7.98 -0.3 6.59e-15 Cardiovascular disease risk factors; BRCA cis rs208520 0.661 rs1776361 chr6:66822270 G/A cg07460842 chr6:66804631 NA -1.0 -20.03 -0.62 1.21e-69 Exhaled nitric oxide output; BRCA cis rs2046867 0.818 rs67355490 chr3:72830935 T/C cg25664220 chr3:72788482 NA -0.51 -10.71 -0.39 1.01e-24 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg16850897 chr7:100343110 ZAN 0.62 13.18 0.46 2.9e-35 Other erythrocyte phenotypes; BRCA cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.0 14.49 0.5 2.52e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs6951245 1.000 rs77305932 chr7:1100861 T/A cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg08213375 chr14:104286397 PPP1R13B 0.61 16.63 0.55 7.5e-52 Schizophrenia; BRCA cis rs12477438 1.000 rs12466388 chr2:99916538 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -13.06 -0.46 1.04e-34 Chronic sinus infection; BRCA trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.45 -0.38 1.08e-23 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg23978390 chr7:1156363 C7orf50 0.4 8.2 0.31 1.36e-15 Bronchopulmonary dysplasia; BRCA cis rs365132 0.905 rs10068703 chr5:176377069 T/A cg16309518 chr5:176445507 NA -0.53 -13.48 -0.47 1.2e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs208520 0.690 rs12202805 chr6:66703903 A/G cg07460842 chr6:66804631 NA -0.95 -19.1 -0.6 1.16e-64 Exhaled nitric oxide output; BRCA cis rs477692 0.905 rs563859 chr10:131417586 T/C cg24747557 chr10:131355152 MGMT -0.31 -7.81 -0.3 2.38e-14 Response to temozolomide; BRCA cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg20908204 chr19:46285434 DMPK -0.27 -8.11 -0.31 2.58e-15 Coronary artery disease; BRCA cis rs586533 0.881 rs634379 chr11:99497472 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.64e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22496380 chr5:211416 CCDC127 -0.99 -14.41 -0.5 5.83e-41 Breast cancer; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg22764044 chr5:178986830 RUFY1 -0.51 -14.24 -0.49 3.53e-40 Lung cancer; BRCA cis rs672059 1.000 rs522372 chr1:183157449 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.37 -8.4 -0.32 2.87e-16 Hypertriglyceridemia; BRCA cis rs28595532 0.623 rs34284204 chr4:119227672 C/T cg21605333 chr4:119757512 SEC24D 0.81 8.48 0.32 1.58e-16 Cannabis dependence symptom count; BRCA cis rs9323205 0.954 rs4898682 chr14:51639577 C/T cg23942311 chr14:51606299 NA -0.38 -8.87 -0.33 7.22e-18 Cancer; BRCA cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg00074818 chr8:8560427 CLDN23 0.39 8.52 0.32 1.14e-16 Obesity-related traits; BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg27170947 chr2:26402098 FAM59B -0.66 -11.24 -0.41 7.23e-27 Gut microbiome composition (summer); BRCA cis rs7666738 0.927 rs6832373 chr4:99051967 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.8 0.39 4.3e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg01191920 chr7:158217561 PTPRN2 -0.36 -8.62 -0.32 5.41e-17 Obesity-related traits; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.79 0.36 3.53e-21 Gut microbiome composition (summer); BRCA cis rs9457247 0.730 rs9459841 chr6:167431949 G/A cg07741184 chr6:167504864 NA 0.28 8.07 0.3 3.58e-15 Crohn's disease; BRCA cis rs708547 0.647 rs1718830 chr4:57888510 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.81 0.36 2.89e-21 Response to bleomycin (chromatid breaks); BRCA cis rs6598955 0.671 rs7550997 chr1:26596080 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.77 0.33 1.64e-17 Obesity-related traits; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg19626725 chr5:178986131 RUFY1 0.35 10.72 0.39 9.34e-25 Lung cancer; BRCA cis rs9296092 0.517 rs3912041 chr6:33521271 T/C cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs738321 0.790 rs4820317 chr22:38543287 T/C cg20207973 chr22:38506712 BAIAP2L2 0.37 9.21 0.34 4.72e-19 Breast cancer; BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA trans rs637571 0.522 rs12792888 chr11:65761446 C/T cg17712092 chr4:129076599 LARP1B 0.62 14.61 0.5 6.27e-42 Eosinophil percentage of white cells; BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -11.43 -0.41 1.18e-27 Platelet count; BRCA cis rs7737355 1.000 rs11242077 chr5:130771037 G/A cg06307176 chr5:131281290 NA -0.53 -10.33 -0.38 3.07e-23 Life satisfaction; BRCA cis rs7264396 0.563 rs17092980 chr20:34289005 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.12 -0.43 1.38e-30 Total cholesterol levels; BRCA cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.05 0.37 3.72e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg07636037 chr3:49044803 WDR6 -0.6 -8.16 -0.31 1.84e-15 Cognitive function; BRCA cis rs911555 0.755 rs6575988 chr14:103900827 G/T cg24130564 chr14:104152367 KLC1 0.39 8.94 0.33 4.31e-18 Intelligence (multi-trait analysis); BRCA cis rs708547 0.671 rs1718863 chr4:57887586 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.79 0.36 3.44e-21 Response to bleomycin (chromatid breaks); BRCA cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.69 -11.69 -0.42 9.71e-29 Schizophrenia; BRCA cis rs701145 0.878 rs355774 chr3:154036196 A/G cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs12949688 0.967 rs7220397 chr17:55823522 C/G cg12582317 chr17:55822272 NA 0.32 7.93 0.3 9.64e-15 Schizophrenia; BRCA cis rs4718428 1.000 rs12534637 chr7:66327654 G/C cg18252515 chr7:66147081 NA -0.42 -9.05 -0.34 1.75e-18 Corneal structure; BRCA cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg02659138 chr7:134003124 SLC35B4 0.32 10.09 0.37 2.59e-22 Mean platelet volume; BRCA cis rs829883 0.966 rs249815 chr12:98893709 A/G cg25150519 chr12:98850993 NA 0.59 11.9 0.43 1.19e-29 Colorectal adenoma (advanced); BRCA cis rs853679 0.517 rs9348793 chr6:28084189 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA cis rs1949733 0.598 rs4696838 chr4:8540349 A/G cg13073564 chr4:8508604 NA 0.31 7.82 0.3 2.11e-14 Response to antineoplastic agents; BRCA cis rs910316 0.737 rs175048 chr14:75479894 A/T cg11812906 chr14:75593930 NEK9 -0.6 -13.7 -0.48 1.22e-37 Height; BRCA cis rs9814567 0.896 rs11915964 chr3:134348930 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 17.84 0.58 4.29e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs243505 0.559 rs10215159 chr7:148479071 G/C cg09806900 chr7:148480153 CUL1 0.56 11.31 0.41 3.71e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg19418458 chr7:158789849 NA 0.44 9.85 0.36 2.16e-21 Facial morphology (factor 20); BRCA cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg20607798 chr8:58055168 NA 0.47 8.35 0.31 4.28e-16 Developmental language disorder (linguistic errors); BRCA cis rs7247513 1.000 rs7247513 chr19:12691185 C/T cg01871581 chr19:12707946 ZNF490 -0.7 -16.54 -0.55 2.07e-51 Bipolar disorder; BRCA cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.76 -0.33 1.79e-17 Monocyte percentage of white cells; BRCA cis rs10949834 0.793 rs810534 chr7:73505045 A/G cg07137043 chr7:73588983 EIF4H 0.51 8.06 0.3 3.87e-15 Verbal memory performance (residualized delayed recall change); BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg00149659 chr3:10157352 C3orf10 0.82 14.4 0.49 6.66e-41 Alzheimer's disease; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg02733842 chr7:1102375 C7orf50 -0.64 -12.44 -0.44 5.73e-32 Bronchopulmonary dysplasia; BRCA cis rs3806843 0.619 rs2569160 chr5:140028774 T/C cg16179182 chr5:140090404 VTRNA1-1 0.45 10.2 0.37 9.64e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg15839431 chr19:19639596 YJEFN3 -0.43 -9.25 -0.34 3.44e-19 Bipolar disorder; BRCA cis rs7246657 0.943 rs4452075 chr19:37879589 A/G cg14683738 chr19:37701593 ZNF585B 0.46 8.08 0.3 3.31e-15 Coronary artery calcification; BRCA cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.76 0.33 1.7e-17 Motion sickness; BRCA trans rs853679 0.607 rs34661125 chr6:28281894 G/A cg06606381 chr12:133084897 FBRSL1 -0.85 -8.84 -0.33 9.03e-18 Depression; BRCA cis rs1153858 1.000 rs4534782 chr15:45652933 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.86 0.42 1.86e-29 Homoarginine levels; BRCA cis rs74377301 1 rs74377301 chr7:123232495 C/T cg03229431 chr7:123269106 ASB15 -0.61 -13.21 -0.46 2.2e-35 Left ventricular obstructive tract defect (inherited effect); BRCA cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg06108461 chr20:60628389 TAF4 -0.8 -17.39 -0.57 9.22e-56 Body mass index; BRCA cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.7 0.36 7.73e-21 Bipolar disorder; BRCA cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.56 11.74 0.42 5.83e-29 Monocyte percentage of white cells; BRCA cis rs72772090 0.634 rs12186366 chr5:96088850 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -13.27 -0.46 1.14e-35 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10206020 0.921 rs11884956 chr2:1566426 A/G cg01028140 chr2:1542097 TPO -0.58 -11.9 -0.43 1.19e-29 IgG glycosylation; BRCA cis rs2046867 0.818 rs6789061 chr3:72888690 C/T cg25664220 chr3:72788482 NA -0.55 -11.8 -0.42 3.33e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2742234 0.554 rs1254963 chr10:43696086 C/T cg15436174 chr10:43711423 RASGEF1A 0.57 11.53 0.41 4.62e-28 Hirschsprung disease; BRCA cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg18225595 chr11:63971243 STIP1 0.5 9.1 0.34 1.15e-18 Mean platelet volume; BRCA cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Alcohol dependence; BRCA cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg00750074 chr16:89608354 SPG7 -0.38 -10.21 -0.37 9e-23 Multiple myeloma (IgH translocation); BRCA cis rs1468333 1.000 rs2967782 chr5:137529682 C/G cg27119451 chr5:137514611 BRD8;KIF20A 0.43 9.19 0.34 5.64e-19 Resting heart rate; BRCA cis rs6546550 0.867 rs4401231 chr2:70063563 G/C cg02498382 chr2:70120550 SNRNP27 -0.51 -10.63 -0.39 2.05e-24 Prevalent atrial fibrillation; BRCA cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg14558114 chr2:88469736 THNSL2 0.63 9.12 0.34 9.38e-19 Plasma clusterin levels; BRCA cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg04267008 chr7:1944627 MAD1L1 -0.52 -11.05 -0.4 4.37e-26 Bipolar disorder and schizophrenia; BRCA cis rs7246657 0.882 rs4803539 chr19:37897522 A/C cg14683738 chr19:37701593 ZNF585B 0.44 7.86 0.3 1.63e-14 Coronary artery calcification; BRCA cis rs7953249 0.935 rs7135337 chr12:121404155 A/C cg02403541 chr12:121454288 C12orf43 -0.39 -8.01 -0.3 5.43e-15 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs514406 0.505 rs425520 chr1:53179805 C/G cg08859206 chr1:53392774 SCP2 -0.42 -8.43 -0.32 2.36e-16 Monocyte count; BRCA cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg20503657 chr10:835505 NA 1.0 15.57 0.52 1.4e-46 Eosinophil percentage of granulocytes; BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 25.48 0.71 2.27e-99 Platelet count; BRCA cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg13902645 chr11:5959945 NA -0.56 -11.48 -0.41 7.11e-28 DNA methylation (variation); BRCA cis rs7539409 0.915 rs4001467 chr1:84275858 A/T cg10977910 chr1:84465055 TTLL7 -0.55 -8.17 -0.31 1.6e-15 Alzheimer's disease; BRCA cis rs2625529 0.824 rs12903484 chr15:72299481 G/A cg16672083 chr15:72433130 SENP8 -0.85 -17.97 -0.58 9.79e-59 Red blood cell count; BRCA cis rs172166 0.694 rs188105 chr6:28071393 C/T cg10876282 chr6:28092338 ZSCAN16 0.42 8.38 0.31 3.4e-16 Cardiac Troponin-T levels; BRCA cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg26384229 chr12:38710491 ALG10B 0.54 13.71 0.48 1.05e-37 Morning vs. evening chronotype; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg04518342 chr5:131593106 PDLIM4 0.37 9.13 0.34 9.14e-19 Breast cancer; BRCA cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg11301795 chr4:187892539 NA -0.31 -10.25 -0.38 6.51e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs1801251 1.000 rs56777991 chr2:233635388 A/C cg25237894 chr2:233734115 C2orf82 0.39 11.22 0.41 8.76e-27 Coronary artery disease; BRCA cis rs1538970 0.961 rs4660854 chr1:45854087 A/T cg05343316 chr1:45956843 TESK2 0.55 11.51 0.41 5.57e-28 Platelet count; BRCA cis rs6089829 0.962 rs1060490 chr20:61665871 A/G cg08045932 chr20:61659980 NA 0.49 11.41 0.41 1.46e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2880765 0.835 rs7180213 chr15:86021187 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.29 -0.31 6.75e-16 Coronary artery disease; BRCA cis rs6142102 0.886 rs6059583 chr20:32532114 T/G cg24642439 chr20:33292090 TP53INP2 0.43 7.84 0.3 1.85e-14 Skin pigmentation; BRCA cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 9.49 0.35 4.4e-20 Rheumatoid arthritis; BRCA cis rs10197940 0.662 rs1047957 chr2:152333773 C/T cg06191203 chr2:152266755 RIF1 -0.31 -9.05 -0.34 1.67e-18 Lung cancer; BRCA cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg23788917 chr6:8435910 SLC35B3 0.47 10.35 0.38 2.53e-23 Motion sickness; BRCA cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.06 -0.49 2.66e-39 Hemoglobin concentration; BRCA cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg26384229 chr12:38710491 ALG10B -0.58 -13.33 -0.47 6.01e-36 Morning vs. evening chronotype; BRCA cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg23711669 chr6:146136114 FBXO30 0.77 17.3 0.56 2.73e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs2625529 0.824 rs7182776 chr15:72462831 A/G cg16672083 chr15:72433130 SENP8 0.73 16.59 0.55 1.16e-51 Red blood cell count; BRCA trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg15934090 chr1:100435551 SLC35A3 0.35 8.16 0.31 1.83e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg27170947 chr2:26402098 FAM59B -0.66 -11.29 -0.41 4.62e-27 Gut microbiome composition (summer); BRCA cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg11644478 chr21:40555479 PSMG1 -0.52 -10.88 -0.4 2.07e-25 Menarche (age at onset); BRCA cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg13902645 chr11:5959945 NA -0.57 -11.57 -0.42 3.16e-28 DNA methylation (variation); BRCA cis rs208520 0.690 rs864314 chr6:66814830 G/A cg07460842 chr6:66804631 NA -1.16 -37.74 -0.83 8.76e-165 Exhaled nitric oxide output; BRCA cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg06713675 chr4:122721982 EXOSC9 -0.53 -12.43 -0.44 6.6e-32 Type 2 diabetes; BRCA cis rs1577917 0.958 rs28442244 chr6:86701236 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 11.84 0.42 2.29e-29 Response to antipsychotic treatment; BRCA cis rs875971 0.545 rs17138149 chr7:65693180 A/G cg11764359 chr7:65958608 NA 0.65 11.75 0.42 5.35e-29 Aortic root size; BRCA trans rs4650994 1.000 rs10798616 chr1:178515642 G/C cg05059571 chr16:84539110 KIAA1609 -0.43 -9.77 -0.36 4.24e-21 HDL cholesterol levels;HDL cholesterol; BRCA cis rs72627509 0.904 rs7687767 chr4:57824932 C/T cg26694713 chr4:57773883 REST -0.5 -9.72 -0.36 6.3e-21 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs12995491 0.902 rs6737641 chr2:88529471 A/T cg04511125 chr2:88470314 THNSL2 -0.45 -9.21 -0.34 4.63e-19 Response to metformin (IC50); BRCA cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg09455208 chr3:40491958 NA 0.39 9.28 0.34 2.58e-19 Renal cell carcinoma; BRCA cis rs9467773 0.620 rs4368798 chr6:26593471 A/G cg11502198 chr6:26597334 ABT1 0.58 12.51 0.44 2.71e-32 Intelligence (multi-trait analysis); BRCA cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg06115741 chr20:33292138 TP53INP2 0.46 10.37 0.38 2.11e-23 Coronary artery disease; BRCA cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg19539972 chr4:7069911 GRPEL1 -0.62 -12.07 -0.43 2.35e-30 Monocyte percentage of white cells; BRCA cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -9.01 -0.34 2.37e-18 Chronic sinus infection; BRCA cis rs738321 0.757 rs2284062 chr22:38544221 A/G cg20207973 chr22:38506712 BAIAP2L2 0.38 9.39 0.35 1e-19 Breast cancer; BRCA cis rs11792861 0.926 rs11787878 chr9:111866749 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.05 0.3 3.95e-15 Menarche (age at onset); BRCA cis rs78487399 0.908 rs73925554 chr2:43810739 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -7.86 -0.3 1.66e-14 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs4363385 0.747 rs6689609 chr1:152967588 G/A cg25856811 chr1:152973957 SPRR3 -0.36 -9.64 -0.36 1.28e-20 Inflammatory skin disease; BRCA cis rs1355223 0.506 rs7131272 chr11:34869548 A/G cg11058730 chr11:34937778 PDHX;APIP 0.48 9.29 0.35 2.32e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs35110281 0.712 rs162345 chr21:44954155 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.1 0.31 2.74e-15 Mean corpuscular volume; BRCA cis rs6723226 0.842 rs1901355 chr2:32835664 A/G cg02381751 chr2:32503542 YIPF4 -0.57 -11.35 -0.41 2.4e-27 Intelligence (multi-trait analysis); BRCA cis rs7011049 1.000 rs77668788 chr8:53856407 C/T cg26025543 chr8:53854495 NA 0.55 9.49 0.35 4.66e-20 Systolic blood pressure; BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs7177699 0.557 rs11072807 chr15:79111517 A/G cg00540400 chr15:79124168 NA 0.28 7.97 0.3 7.19e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs6430585 0.759 rs4954623 chr2:136535876 G/A cg07169764 chr2:136633963 MCM6 -1.08 -22.04 -0.66 1.76e-80 Corneal structure; BRCA cis rs4631830 0.720 rs2125771 chr10:51506957 C/T cg20129853 chr10:51489980 NA -0.32 -8.34 -0.31 4.57e-16 Prostate-specific antigen levels; BRCA cis rs9486719 1.000 rs72931061 chr6:96880285 G/A cg06623918 chr6:96969491 KIAA0776 -0.73 -12.95 -0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs17270561 0.609 rs1185976 chr6:25822363 A/G cg17691542 chr6:26056736 HIST1H1C -0.44 -9.41 -0.35 8.99e-20 Iron status biomarkers; BRCA cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.13 -0.37 1.85e-22 IgG glycosylation; BRCA cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg18404041 chr3:52824283 ITIH1 0.52 16.42 0.54 8.26e-51 Bipolar disorder; BRCA cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA trans rs6582630 0.502 rs8186661 chr12:38380781 G/A cg06521331 chr12:34319734 NA -0.51 -9.09 -0.34 1.2e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg11608241 chr8:8085544 FLJ10661 -0.37 -10.17 -0.37 1.28e-22 Neuroticism; BRCA cis rs6740322 0.843 rs6727237 chr2:43562000 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -12.03 -0.43 3.49e-30 Coronary artery disease; BRCA cis rs72634258 0.554 rs12723500 chr1:7857374 G/C cg26816564 chr1:7831052 VAMP3 0.73 12.92 0.46 4.29e-34 Inflammatory bowel disease; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg24060327 chr5:131705240 SLC22A5 -0.46 -9.15 -0.34 7.57e-19 Acylcarnitine levels; BRCA cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg25319279 chr11:5960081 NA -0.44 -8.55 -0.32 9.13e-17 DNA methylation (variation); BRCA cis rs7973719 0.868 rs12825629 chr12:7355583 T/C cg07052231 chr12:7363540 PEX5 0.36 8.17 0.31 1.66e-15 IgG glycosylation; BRCA cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg10523679 chr1:76189770 ACADM -0.61 -11.66 -0.42 1.34e-28 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs7647973 0.592 rs6774202 chr3:49687779 T/G cg21659725 chr3:3221576 CRBN -0.46 -8.54 -0.32 9.54e-17 Menarche (age at onset); BRCA trans rs2204008 0.744 rs67889662 chr12:38327042 T/A cg06521331 chr12:34319734 NA -0.53 -9.45 -0.35 6.4e-20 Bladder cancer; BRCA cis rs9300255 0.679 rs28583837 chr12:123863620 G/A cg00376283 chr12:123451042 ABCB9 -0.52 -10.65 -0.39 1.74e-24 Neutrophil percentage of white cells; BRCA cis rs6121246 0.909 rs6058450 chr20:30343911 G/A cg21427119 chr20:30132790 HM13 -0.41 -8.75 -0.33 1.93e-17 Mean corpuscular hemoglobin; BRCA cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg03433033 chr1:76189801 ACADM -0.74 -16.28 -0.54 4.36e-50 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4363385 0.747 rs1015995 chr1:152976114 G/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs12142240 0.698 rs6679898 chr1:46820589 A/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.39 0.57 1.01e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs28830936 1.000 rs17678767 chr15:42096422 C/G cg17847044 chr15:42102381 MAPKBP1 -0.37 -10.09 -0.37 2.67e-22 Diastolic blood pressure; BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg16606324 chr3:10149918 C3orf24 0.5 9.56 0.35 2.53e-20 Alzheimer's disease; BRCA cis rs2717559 0.683 rs2717611 chr8:143879927 C/T cg20108693 chr8:143823809 SLURP1 0.26 7.83 0.3 1.99e-14 Urinary tract infection frequency; BRCA trans rs7615952 0.599 rs16834938 chr3:125706046 C/T cg07211511 chr3:129823064 LOC729375 -0.6 -10.94 -0.4 1.23e-25 Blood pressure (smoking interaction); BRCA cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg02280532 chr2:160761244 LY75 -0.38 -8.41 -0.32 2.71e-16 Crohn's disease;Inflammatory bowel disease; BRCA trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg03929089 chr4:120376271 NA 0.61 10.56 0.39 3.97e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs523522 0.962 rs655530 chr12:121022275 T/C cg27279351 chr12:120934652 DYNLL1 0.56 13.41 0.47 2.63e-36 High light scatter reticulocyte count; BRCA cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg06484146 chr7:12443880 VWDE -0.75 -10.63 -0.39 2.15e-24 Coronary artery disease; BRCA cis rs7592578 0.679 rs62181020 chr2:191325601 A/C cg11845111 chr2:191398756 TMEM194B -0.71 -13.83 -0.48 2.95e-38 Diastolic blood pressure; BRCA cis rs7592578 0.581 rs59109438 chr2:191287683 A/G cg11845111 chr2:191398756 TMEM194B -0.71 -13.61 -0.47 3.01e-37 Diastolic blood pressure; BRCA cis rs1801251 1.000 rs1446311 chr2:233705071 G/A cg08000102 chr2:233561755 GIGYF2 -0.63 -13.61 -0.47 3.18e-37 Coronary artery disease; BRCA cis rs12579753 0.917 rs12311988 chr12:82177209 C/A cg07988820 chr12:82153109 PPFIA2 -0.47 -8.09 -0.3 3.05e-15 Resting heart rate; BRCA cis rs738322 0.804 rs2076116 chr22:38517405 A/G cg20207973 chr22:38506712 BAIAP2L2 0.39 10.22 0.37 7.86e-23 Cutaneous nevi; BRCA cis rs7246657 0.943 rs1373991 chr19:37838911 T/C cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA cis rs6088813 0.922 rs4911493 chr20:33960799 A/G cg14752227 chr20:34000481 UQCC -0.42 -8.95 -0.33 3.77e-18 Height; BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg03709012 chr19:19516395 GATAD2A 0.8 18.71 0.6 1.21e-62 Tonsillectomy; BRCA cis rs7408868 1.000 rs7247906 chr19:15271135 T/G cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs329648 0.667 rs11223616 chr11:133772838 C/T cg03392386 chr11:133800800 IGSF9B 0.39 8.11 0.31 2.62e-15 Parkinson's disease; BRCA cis rs7580658 0.963 rs62157555 chr2:128107176 C/T cg09760422 chr2:128146352 NA -0.35 -7.88 -0.3 1.43e-14 Protein C levels; BRCA cis rs636291 0.510 rs1307487 chr1:10506667 G/A cg17425144 chr1:10567563 PEX14 0.47 11.39 0.41 1.73e-27 Prostate cancer; BRCA cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg23992470 chr4:843637 GAK 0.54 8.16 0.31 1.84e-15 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs11098499 0.954 rs10518328 chr4:120401779 G/A cg09307838 chr4:120376055 NA 0.72 15.32 0.52 2.36e-45 Corneal astigmatism; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 18.18 0.58 7.82e-60 Platelet count; BRCA cis rs10193935 0.901 rs1044562 chr2:42516884 C/G cg27598129 chr2:42591480 NA -0.92 -14.7 -0.5 2.33e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg22920501 chr2:26401640 FAM59B 0.94 16.23 0.54 7.34e-50 Gut microbiome composition (summer); BRCA cis rs2346177 0.519 rs35509718 chr2:46696793 T/C cg02822958 chr2:46747628 ATP6V1E2 0.57 11.02 0.4 5.42e-26 HDL cholesterol; BRCA cis rs7737355 0.947 rs13163091 chr5:130836041 A/G cg06307176 chr5:131281290 NA -0.51 -10.24 -0.38 6.83e-23 Life satisfaction; BRCA cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg06640241 chr16:89574553 SPG7 0.86 22.17 0.66 3.15e-81 Multiple myeloma (IgH translocation); BRCA cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg06494592 chr3:125709126 NA -0.52 -8.14 -0.31 2.08e-15 Blood pressure (smoking interaction); BRCA cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -7.97 -0.3 7.2e-15 Obesity-related traits; BRCA trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21659725 chr3:3221576 CRBN 0.5 12.61 0.45 9.97e-33 Intelligence (multi-trait analysis); BRCA cis rs3815700 1.000 rs3815700 chr19:33093252 T/C cg02997394 chr19:33096574 ANKRD27 0.69 11.5 0.41 6.21e-28 Eosinophilic esophagitis; BRCA cis rs2836950 0.805 rs62223042 chr21:40683740 A/G cg11644478 chr21:40555479 PSMG1 -0.42 -8.28 -0.31 7.08e-16 Menarche (age at onset); BRCA cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg02931644 chr1:25747376 RHCE 0.4 11.34 0.41 2.83e-27 Erythrocyte sedimentation rate; BRCA cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.58 0.5 8.71e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg02574844 chr11:5959923 NA -0.42 -8.29 -0.31 6.93e-16 DNA methylation (variation); BRCA cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.87 0.4 2.17e-25 Depressive symptoms (multi-trait analysis); BRCA trans rs6951245 0.554 rs79367977 chr7:1152657 G/A cg13565492 chr6:43139072 SRF -0.87 -15.94 -0.53 1.99e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9649465 0.934 rs34030532 chr7:123274992 A/G cg03229431 chr7:123269106 ASB15 -0.36 -8.37 -0.31 3.59e-16 Migraine; BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg23708337 chr7:1209742 NA 0.51 8.71 0.33 2.56e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1577917 0.917 rs1584273 chr6:86524577 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs11690935 1.000 rs2138348 chr2:172558172 A/C cg13550731 chr2:172543902 DYNC1I2 0.89 27.6 0.74 5.37e-111 Schizophrenia; BRCA cis rs2288073 0.965 rs36101491 chr2:24387532 C/T cg06627628 chr2:24431161 ITSN2 -0.66 -12.14 -0.43 1.13e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg18876405 chr7:65276391 NA 0.48 10.83 0.39 3.43e-25 Aortic root size; BRCA cis rs9443189 0.570 rs7770824 chr6:76408189 G/A cg01950844 chr6:76311363 SENP6 0.84 13.57 0.47 5.09e-37 Prostate cancer; BRCA cis rs8077889 0.672 rs1230397 chr17:41844689 A/G cg26893861 chr17:41843967 DUSP3 1.07 31.68 0.78 3.92e-133 Triglycerides; BRCA cis rs9297145 0.585 rs10953281 chr7:98772131 C/T cg05967295 chr7:98741636 SMURF1 -0.61 -13.92 -0.48 1.13e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7617773 0.780 rs6793239 chr3:48351618 G/T cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs2624839 0.602 rs2526390 chr3:50192760 C/T cg14019146 chr3:50243930 SLC38A3 -0.68 -16.96 -0.56 1.47e-53 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs2797160 0.904 rs1612274 chr6:126014907 C/A cg05901451 chr6:126070800 HEY2 0.41 9.84 0.36 2.37e-21 Endometrial cancer; BRCA trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.89 -0.48 1.66e-38 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg25036284 chr2:26402008 FAM59B -0.63 -10.22 -0.37 8.23e-23 Gut microbiome composition (summer); BRCA cis rs9287719 0.674 rs10929690 chr2:10805974 T/C cg00105475 chr2:10696890 NA -0.39 -8.91 -0.33 5.27e-18 Prostate cancer; BRCA trans rs17685 0.753 rs1104879 chr7:75685568 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 27.71 0.74 1.28e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2576037 0.796 rs2571020 chr18:44584189 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 8.36 0.31 3.8e-16 Personality dimensions; BRCA cis rs11249608 0.548 rs17078988 chr5:178459283 A/G cg21905437 chr5:178450457 ZNF879 0.5 10.59 0.39 2.93e-24 Pubertal anthropometrics; BRCA cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.57 12.95 0.46 3.3e-34 Personality dimensions; BRCA cis rs35740288 0.929 rs3858927 chr15:86301616 C/G cg20737812 chr15:86336631 KLHL25 -0.32 -8.01 -0.3 5.53e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg03060546 chr3:49711283 APEH 0.58 8.42 0.32 2.57e-16 Menarche (age at onset); BRCA cis rs6598955 0.543 rs6699798 chr1:26556442 G/T cg04990556 chr1:26633338 UBXN11 0.71 11.98 0.43 5.61e-30 Obesity-related traits; BRCA cis rs2304069 0.955 rs4288106 chr5:149394872 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.82 16.6 0.55 1.03e-51 HIV-1 control; BRCA cis rs4242434 0.699 rs878053 chr8:22483849 T/C cg03733263 chr8:22462867 KIAA1967 0.79 17.9 0.58 2.27e-58 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg00631329 chr6:26305371 NA -0.44 -13.0 -0.46 1.8e-34 Educational attainment; BRCA trans rs11098499 0.754 rs1511025 chr4:120240238 T/C cg25214090 chr10:38739885 LOC399744 0.44 10.29 0.38 4.34e-23 Corneal astigmatism; BRCA cis rs7577696 0.568 rs177082 chr2:32438350 A/T cg02381751 chr2:32503542 YIPF4 0.47 8.59 0.32 6.72e-17 Inflammatory biomarkers; BRCA cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -17.86 -0.58 3.55e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -11.11 -0.4 2.42e-26 Bipolar disorder and schizophrenia; BRCA cis rs10504073 0.647 rs2292399 chr8:49987230 A/G cg00325661 chr8:49890786 NA 0.44 12.52 0.44 2.55e-32 Blood metabolite ratios; BRCA cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 0.628 rs4949686 chr1:76473299 G/C cg10523679 chr1:76189770 ACADM 0.63 10.29 0.38 4.49e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9308433 0.529 rs4655244 chr1:214497580 A/G cg06198575 chr1:214491504 SMYD2 0.56 12.24 0.44 4.43e-31 IgG glycosylation; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg25482853 chr8:67687455 SGK3 1.02 17.31 0.56 2.46e-55 Lung disease severity in cystic fibrosis; BRCA cis rs4919087 0.926 rs953097 chr10:98981914 T/C cg25902810 chr10:99078978 FRAT1 0.41 8.82 0.33 1.07e-17 Monocyte count; BRCA cis rs12611088 0.602 rs2599455 chr19:44025235 T/A cg15012607 chr19:44012195 ETHE1 -0.34 -8.31 -0.31 5.57e-16 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs654351 0.572 rs556578 chr6:10388755 T/C cg17959970 chr6:10383164 NA -0.41 -8.55 -0.32 8.77e-17 Squamous cell lung carcinoma; BRCA cis rs778371 0.723 rs35491427 chr2:233688542 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -17.01 -0.56 8.62e-54 Schizophrenia; BRCA cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg08213375 chr14:104286397 PPP1R13B 0.66 18.7 0.59 1.49e-62 Schizophrenia; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.18 -0.31 1.54e-15 Total body bone mineral density; BRCA cis rs754466 0.914 rs4595491 chr10:79685833 G/A cg17075019 chr10:79541650 NA -0.63 -11.97 -0.43 6.22e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg13010199 chr12:38710504 ALG10B 0.4 9.17 0.34 6.36e-19 Morning vs. evening chronotype; BRCA cis rs4713118 0.662 rs156744 chr6:27967274 G/A cg16479474 chr6:28041457 NA 0.42 7.82 0.3 2.18e-14 Parkinson's disease; BRCA cis rs12541635 0.966 rs1496182 chr8:107024505 C/T cg10147462 chr8:107024639 NA 0.37 10.39 0.38 1.73e-23 Age of smoking initiation; BRCA trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg13010199 chr12:38710504 ALG10B 0.43 9.16 0.34 6.75e-19 Morning vs. evening chronotype; BRCA cis rs4268898 0.552 rs11125454 chr2:24373669 T/C cg06627628 chr2:24431161 ITSN2 0.41 8.61 0.32 5.54e-17 Asthma; BRCA cis rs7666738 0.687 rs6830176 chr4:99093955 G/C cg05340658 chr4:99064831 C4orf37 0.5 10.86 0.39 2.59e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg23131131 chr22:24373011 LOC391322 -0.46 -11.07 -0.4 3.39e-26 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg00080972 chr5:178986291 RUFY1 0.51 14.01 0.48 4.23e-39 Lung cancer; BRCA cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12292205 chr6:26970375 C6orf41 -0.48 -8.25 -0.31 8.81e-16 Intelligence (multi-trait analysis); BRCA cis rs10206020 0.921 rs9678719 chr2:1549628 A/G cg12573674 chr2:1569213 NA -0.54 -11.41 -0.41 1.46e-27 IgG glycosylation; BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg25036284 chr2:26402008 FAM59B -0.96 -16.12 -0.54 2.62e-49 Gut microbiome composition (summer); BRCA cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg16414030 chr3:133502952 NA -0.54 -12.51 -0.44 2.88e-32 Iron status biomarkers; BRCA cis rs16866061 1.000 rs11694987 chr2:225397409 C/G cg12698349 chr2:225449008 CUL3 0.74 18.5 0.59 1.72e-61 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7267979 1.000 rs7020 chr20:25278600 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.32 9.13 0.34 8.91e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9467773 0.596 rs62396201 chr6:26668216 G/A cg09904177 chr6:26538194 HMGN4 0.43 13.28 0.46 1.06e-35 Intelligence (multi-trait analysis); BRCA cis rs11920090 0.722 rs5404 chr3:170724955 A/G cg09710316 chr3:170744871 SLC2A2 -0.57 -9.94 -0.37 9.37e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg09658497 chr7:2847517 GNA12 -0.41 -8.62 -0.32 5.29e-17 Height; BRCA cis rs2404602 0.735 rs2436994 chr15:76801063 G/C cg23625390 chr15:77176239 SCAPER -0.51 -12.95 -0.46 3.12e-34 Blood metabolite levels; BRCA cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6752107 0.967 rs10210302 chr2:234158839 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.5 11.2 0.41 9.96e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs4845875 0.563 rs11121829 chr1:11834765 A/G cg24844545 chr1:11908347 NPPA 0.37 8.53 0.32 1.05e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs7085104 0.700 rs6163 chr10:104596924 C/A cg04362960 chr10:104952993 NT5C2 0.4 9.57 0.35 2.2e-20 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs7580658 0.963 rs10803585 chr2:128130108 G/A cg09760422 chr2:128146352 NA -0.35 -7.84 -0.3 1.83e-14 Protein C levels; BRCA trans rs8002861 0.664 rs9567292 chr13:44444816 A/G cg17145862 chr1:211918768 LPGAT1 0.48 10.82 0.39 3.68e-25 Leprosy; BRCA cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03264133 chr6:25882463 NA 0.43 9.05 0.34 1.73e-18 Intelligence (multi-trait analysis); BRCA cis rs13315871 1.000 rs12330157 chr3:58364562 C/T cg20936604 chr3:58311152 NA -0.62 -7.94 -0.3 9.28e-15 Cholesterol, total; BRCA cis rs9359856 0.564 rs17228548 chr6:90439164 T/C cg13799429 chr6:90582589 CASP8AP2 -0.71 -8.58 -0.32 7.04e-17 Bipolar disorder; BRCA trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg23505145 chr19:12996616 KLF1 0.53 12.23 0.44 4.91e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs8014204 0.836 rs888413 chr14:75267396 C/T cg06637938 chr14:75390232 RPS6KL1 0.58 12.3 0.44 2.4e-31 Caffeine consumption; BRCA cis rs9868809 0.772 rs2302295 chr3:48690110 T/C cg07636037 chr3:49044803 WDR6 -0.59 -8.13 -0.31 2.31e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs3768617 0.510 rs2027075 chr1:183073266 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.11e-57 Fuchs's corneal dystrophy; BRCA cis rs7607369 0.791 rs72965151 chr2:219344165 G/T cg02176678 chr2:219576539 TTLL4 -0.54 -13.62 -0.47 2.78e-37 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs9290065 0.519 rs6808386 chr3:160673263 A/T cg03342759 chr3:160939853 NMD3 -0.46 -9.37 -0.35 1.22e-19 Kawasaki disease; BRCA cis rs2832191 0.716 rs7284006 chr21:30475186 T/A cg24692254 chr21:30365293 RNF160 0.79 22.31 0.66 5.3e-82 Dental caries; BRCA cis rs8077889 0.763 rs4792913 chr17:41854497 T/C cg26893861 chr17:41843967 DUSP3 0.9 23.21 0.68 6.78e-87 Triglycerides; BRCA cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg20607798 chr8:58055168 NA 0.45 7.88 0.3 1.38e-14 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg21143896 chr7:2802374 GNA12 -0.37 -9.33 -0.35 1.7e-19 Height; BRCA cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg23583168 chr7:148888333 NA 0.85 19.95 0.62 3.23e-69 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.51 -11.76 -0.42 5.05e-29 Brugada syndrome; BRCA cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs4727027 0.704 rs13221837 chr7:148903597 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.4 8.39 0.32 3.08e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.2 0.34 5.08e-19 Systemic lupus erythematosus; BRCA cis rs12611088 0.515 rs2599454 chr19:44025201 T/C cg13740135 chr19:44006432 PHLDB3 -0.3 -7.88 -0.3 1.39e-14 Plasma amyloid beta peptide concentrations (ABx-42); BRCA trans rs79976124 0.837 rs10455591 chr6:66650584 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.61 10.81 0.39 3.81e-25 Type 2 diabetes; BRCA cis rs7851660 0.967 rs7851552 chr9:100610652 C/A cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.81e-17 Strep throat; BRCA cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg11764359 chr7:65958608 NA 0.6 12.91 0.45 4.97e-34 Aortic root size; BRCA cis rs11971779 0.715 rs55714903 chr7:139074590 T/C cg07862535 chr7:139043722 LUC7L2 0.41 11.16 0.4 1.46e-26 Diisocyanate-induced asthma; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg23708337 chr7:1209742 NA 0.37 7.8 0.3 2.44e-14 Longevity;Endometriosis; BRCA cis rs9790314 0.934 rs455386 chr3:161102495 A/T cg03342759 chr3:160939853 NMD3 -0.64 -13.34 -0.47 5.41e-36 Morning vs. evening chronotype; BRCA cis rs4363385 0.818 rs382653 chr1:153006761 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.18e-19 Inflammatory skin disease; BRCA cis rs12579753 0.879 rs11115007 chr12:82164673 A/T cg07988820 chr12:82153109 PPFIA2 -0.63 -10.8 -0.39 4.46e-25 Resting heart rate; BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -7.85 -0.3 1.78e-14 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg04166393 chr7:2884313 GNA12 0.49 9.39 0.35 1.03e-19 Height; BRCA cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg05294307 chr14:35346193 BAZ1A -0.63 -10.5 -0.38 6.59e-24 Psoriasis; BRCA cis rs763014 1.000 rs7205409 chr16:642610 A/G cg04709771 chr16:646395 RAB40C 0.42 10.4 0.38 1.7e-23 Height; BRCA cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.43e-20 Menopause (age at onset); BRCA cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg12893428 chr3:195717962 SDHAP1 0.33 8.2 0.31 1.34e-15 Pancreatic cancer; BRCA cis rs7631605 0.905 rs1468713 chr3:37106115 A/G cg15934958 chr3:37212084 LRRFIP2 0.46 10.74 0.39 7.41e-25 Cerebrospinal P-tau181p levels; BRCA cis rs9291683 0.609 rs7678012 chr4:9993772 T/C cg00071950 chr4:10020882 SLC2A9 0.57 14.21 0.49 5.29e-40 Bone mineral density; BRCA cis rs17401966 0.838 rs9332414 chr1:10326963 C/T cg03954927 chr1:10346856 KIF1B 0.43 13.95 0.48 8.08e-39 Hepatocellular carcinoma; BRCA cis rs757081 0.671 rs214090 chr11:17297161 C/T cg15432903 chr11:17409602 KCNJ11 -0.47 -8.1 -0.31 2.75e-15 Systolic blood pressure; BRCA cis rs13102973 0.965 rs13108037 chr4:135885643 A/G cg14419869 chr4:135874104 NA -0.5 -10.52 -0.38 5.72e-24 Subjective well-being; BRCA cis rs2249625 0.545 rs2249021 chr6:72889472 A/G cg18830697 chr6:72922368 RIMS1 -0.63 -14.34 -0.49 1.19e-40 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs9287719 0.649 rs11684537 chr2:10734832 C/T cg00105475 chr2:10696890 NA 0.42 9.42 0.35 8.18e-20 Prostate cancer; BRCA cis rs2066819 1.000 rs11171806 chr12:56733531 A/G cg26714650 chr12:56694279 CS 1.18 15.57 0.52 1.35e-46 Psoriasis vulgaris; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg22907277 chr7:1156413 C7orf50 0.59 9.19 0.34 5.4e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7809950 0.954 rs3779494 chr7:107250355 G/A cg23024343 chr7:107201750 COG5 0.41 8.94 0.33 4.19e-18 Coronary artery disease; BRCA cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -11.14 -0.4 1.77e-26 Personality dimensions; BRCA cis rs897080 0.515 rs786417 chr2:44688766 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.54 9.95 0.37 8.78e-22 Height; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg25036284 chr2:26402008 FAM59B -0.95 -16.1 -0.54 3.42e-49 Gut microbiome composition (summer); BRCA cis rs1499614 0.522 rs13247442 chr7:66188858 T/C cg18252515 chr7:66147081 NA -0.96 -10.69 -0.39 1.15e-24 Gout; BRCA cis rs4742903 0.967 rs7871759 chr9:106865438 A/G cg21169611 chr9:106856078 SMC2 0.36 9.43 0.35 7.52e-20 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs858239 0.601 rs929507 chr7:23166664 G/C cg23682824 chr7:23144976 KLHL7 0.45 11.94 0.43 8.21e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg14844989 chr11:31128820 NA -0.45 -9.66 -0.36 1.11e-20 Red blood cell count; BRCA cis rs1865760 0.786 rs1436308 chr6:25939567 T/G cg16482183 chr6:26056742 HIST1H1C 0.5 10.23 0.38 7.45e-23 Height; BRCA cis rs1941023 0.503 rs11230288 chr11:60128968 G/A cg08716584 chr11:60157161 MS4A7 -0.42 -9.91 -0.36 1.28e-21 Congenital heart disease (maternal effect); BRCA cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg21770322 chr7:97807741 LMTK2 0.45 11.78 0.42 4.14e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg01858014 chr14:56050164 KTN1 -0.73 -10.81 -0.39 3.79e-25 Putamen volume; BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.27 0.56 3.83e-55 Alzheimer's disease; BRCA cis rs6496044 0.568 rs12898783 chr15:86066100 G/C cg10818794 chr15:86012489 AKAP13 -0.29 -7.91 -0.3 1.1e-14 Interstitial lung disease; BRCA cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg06159980 chr1:16340746 HSPB7 -0.38 -7.86 -0.3 1.63e-14 Dilated cardiomyopathy; BRCA cis rs7851660 0.933 rs13302470 chr9:100615553 A/G cg13688889 chr9:100608707 NA -0.36 -8.72 -0.33 2.42e-17 Strep throat; BRCA cis rs12541635 0.677 rs10086055 chr8:107024129 C/T cg10147462 chr8:107024639 NA 0.37 10.13 0.37 1.89e-22 Age of smoking initiation; BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg22920501 chr2:26401640 FAM59B -0.65 -11.24 -0.41 7.02e-27 Gut microbiome composition (summer); BRCA cis rs6089584 0.830 rs6089309 chr20:60585687 T/C cg13770153 chr20:60521292 NA -0.45 -10.4 -0.38 1.71e-23 Body mass index; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg20224285 chr3:52813920 ITIH1 0.32 8.02 0.3 5.01e-15 Bipolar disorder; BRCA cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.49 10.76 0.39 6.15e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9309711 0.736 rs9678647 chr2:3497036 A/G cg10845886 chr2:3471009 TTC15 0.55 10.75 0.39 7.08e-25 Neurofibrillary tangles; BRCA cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.25 0.59 3.49e-60 Schizophrenia; BRCA cis rs6121246 0.697 rs6060912 chr20:30325755 C/A cg21427119 chr20:30132790 HM13 -0.41 -8.78 -0.33 1.53e-17 Mean corpuscular hemoglobin; BRCA cis rs941764 1.000 rs941764 chr14:91841069 C/T cg10511902 chr14:91842949 CCDC88C -0.43 -10.22 -0.37 8.27e-23 Breast cancer; BRCA cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg22467129 chr15:76604101 ETFA 0.53 12.36 0.44 1.27e-31 Blood metabolite levels; BRCA cis rs4363385 0.747 rs61811427 chr1:152968419 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.6 -0.36 1.74e-20 Inflammatory skin disease; BRCA cis rs17376456 1.000 rs61132622 chr5:93539684 G/A cg25358565 chr5:93447407 FAM172A 1.16 18.51 0.59 1.37e-61 Diabetic retinopathy; BRCA cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg19539972 chr4:7069911 GRPEL1 0.69 16.97 0.56 1.43e-53 Monocyte percentage of white cells; BRCA cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg05234568 chr11:5960015 NA -0.44 -9.54 -0.35 2.85e-20 DNA methylation (variation); BRCA cis rs11719291 0.667 rs9877542 chr3:48748545 C/T cg00383909 chr3:49044727 WDR6 0.59 11.1 0.4 2.62e-26 Cognitive function; BRCA cis rs2625529 0.730 rs2957368 chr15:72329906 C/T cg16672083 chr15:72433130 SENP8 -0.7 -16.56 -0.55 1.55e-51 Red blood cell count; BRCA cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg22875332 chr1:76189707 ACADM 0.61 11.64 0.42 1.57e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1691799 0.836 rs1168334 chr12:66760972 A/G cg16791601 chr12:66731901 HELB -0.64 -17.28 -0.56 3.69e-55 White blood cell count (basophil); BRCA cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.4 11.6 0.42 2.26e-28 Monocyte percentage of white cells; BRCA cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg24642439 chr20:33292090 TP53INP2 0.53 11.6 0.42 2.23e-28 Glomerular filtration rate (creatinine); BRCA cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg23289794 chr7:2394357 EIF3B -0.65 -11.94 -0.43 8.07e-30 Multiple sclerosis; BRCA cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg04034577 chr2:241836375 C2orf54 -0.53 -12.07 -0.43 2.35e-30 Urinary metabolites; BRCA trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 5.67e-52 Morning vs. evening chronotype; BRCA trans rs6479891 0.822 rs6479892 chr10:65052232 A/G cg14819942 chr15:35414228 NA -0.34 -8.45 -0.32 1.93e-16 Arthritis (juvenile idiopathic); BRCA cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs495337 1.000 rs6125829 chr20:48568929 A/C cg17835207 chr20:48524531 SPATA2 0.57 12.96 0.46 2.83e-34 Psoriasis; BRCA trans rs2204008 0.689 rs1581357 chr12:38391479 C/G cg06521331 chr12:34319734 NA -0.46 -8.38 -0.31 3.31e-16 Bladder cancer; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg22963979 chr7:1858916 MAD1L1 -0.38 -8.17 -0.31 1.61e-15 Bipolar disorder and schizophrenia; BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24549020 chr5:56110836 MAP3K1 0.64 13.26 0.46 1.29e-35 Initial pursuit acceleration; BRCA cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.59e-17 Developmental language disorder (linguistic errors); BRCA cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg14983838 chr19:29218262 NA 0.54 10.08 0.37 2.78e-22 Methadone dose in opioid dependence; BRCA cis rs72781680 0.898 rs72786270 chr2:24059049 G/A cg20701182 chr2:24300061 SF3B14 0.58 8.98 0.33 2.94e-18 Lymphocyte counts; BRCA cis rs11711311 1.000 rs12497716 chr3:113453258 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.35 9.12 0.34 9.44e-19 IgG glycosylation; BRCA trans rs615632 0.570 rs17734541 chr8:9708433 A/G cg06636001 chr8:8085503 FLJ10661 0.41 8.36 0.31 3.86e-16 Neuroticism; BRCA cis rs7412746 0.658 rs2272214 chr1:150931462 C/T cg15448220 chr1:150897856 SETDB1 0.35 7.98 0.3 6.75e-15 Melanoma; BRCA cis rs2404602 0.647 rs4886837 chr15:77156417 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.9 -0.48 1.42e-38 Blood metabolite levels; BRCA cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -11.66 -0.42 1.23e-28 Chronic sinus infection; BRCA cis rs13102973 0.932 rs6858552 chr4:135864734 C/T cg14419869 chr4:135874104 NA -0.59 -12.9 -0.45 5.35e-34 Subjective well-being; BRCA cis rs8028182 0.636 rs4564532 chr15:75706296 C/G cg20655648 chr15:75932815 IMP3 0.4 7.88 0.3 1.39e-14 Sudden cardiac arrest; BRCA cis rs736408 0.812 rs9324 chr3:52825585 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 8.3 0.31 6.09e-16 Bipolar disorder; BRCA cis rs9837602 1.000 rs9851645 chr3:99767409 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.24 0.41 7.07e-27 Breast cancer; BRCA cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs3784262 0.967 rs4646612 chr15:58265077 C/T cg12031962 chr15:58353849 ALDH1A2 -0.48 -12.81 -0.45 1.28e-33 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1997103 1.000 rs2331064 chr7:55408610 C/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA trans rs9409565 0.821 rs9299419 chr9:97066584 C/T cg05679027 chr9:99775184 HIATL2 0.36 7.92 0.3 1.03e-14 Colorectal cancer (alcohol consumption interaction); BRCA cis rs7818345 0.967 rs4481612 chr8:19285336 T/G cg11303988 chr8:19266685 CSGALNACT1 0.31 8.2 0.31 1.34e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs17092148 1.000 rs62211612 chr20:33386156 C/T cg16810054 chr20:33298113 TP53INP2 0.49 11.17 0.4 1.35e-26 Neuroticism; BRCA cis rs6831352 1.000 rs6532798 chr4:100054827 C/T cg12011299 chr4:100065546 ADH4 0.53 12.95 0.46 3.03e-34 Alcohol dependence; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.52 9.96 0.37 8.28e-22 Lung cancer in ever smokers; BRCA cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg05234568 chr11:5960015 NA -0.42 -8.73 -0.33 2.23e-17 DNA methylation (variation); BRCA trans rs11039798 0.623 rs588700 chr11:48449889 T/C cg15704280 chr7:45808275 SEPT13 -0.57 -9.5 -0.35 4.13e-20 Axial length; BRCA cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.89 -0.33 6.2e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg24642439 chr20:33292090 TP53INP2 0.43 8.55 0.32 8.86e-17 Height; BRCA cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.49 -10.85 -0.39 2.62e-25 IgG glycosylation; BRCA cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg03146154 chr1:46216737 IPP 0.52 11.69 0.42 1e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs34779708 0.931 rs11597483 chr10:35285117 A/G cg03585969 chr10:35415529 CREM 0.56 11.49 0.41 6.62e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg25703541 chr22:24373054 LOC391322 -0.7 -16.09 -0.54 3.64e-49 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4664304 0.620 rs11895141 chr2:160716449 T/A cg14819504 chr2:160761413 LY75 0.34 8.47 0.32 1.65e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9300255 0.722 rs67624109 chr12:123824635 C/T cg00376283 chr12:123451042 ABCB9 -0.52 -10.76 -0.39 6.03e-25 Neutrophil percentage of white cells; BRCA cis rs6546886 0.957 rs6546887 chr2:74250781 C/G cg14702570 chr2:74259524 NA -0.32 -7.96 -0.3 7.94e-15 Dialysis-related mortality; BRCA cis rs1499972 0.941 rs62263122 chr3:117630669 T/C cg07612923 chr3:117604196 NA 0.6 8.15 0.31 1.97e-15 Schizophrenia; BRCA cis rs11098499 0.908 rs11729050 chr4:120300066 T/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs11229555 0.874 rs12800710 chr11:58314540 C/T cg15696309 chr11:58395628 NA -0.54 -11.69 -0.42 9.47e-29 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1371614 0.523 rs11904656 chr2:27173249 G/A cg00617064 chr2:27272375 NA -0.31 -7.9 -0.3 1.22e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg22431228 chr1:16359049 CLCNKA -0.49 -11.07 -0.4 3.64e-26 Systolic blood pressure; BRCA cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg26031613 chr14:104095156 KLC1 -0.46 -8.93 -0.33 4.4e-18 Schizophrenia; BRCA cis rs9463078 0.727 rs9463054 chr6:44917197 T/C cg25276700 chr6:44698697 NA -0.36 -8.43 -0.32 2.36e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4595586 0.545 rs7970850 chr12:39397878 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs13191362 0.507 rs2846535 chr6:163034019 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.46 -8.84 -0.33 9.59e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.16 0.4 1.5e-26 Rheumatoid arthritis; BRCA cis rs28735056 1.000 rs4798922 chr18:77628953 G/C cg20368463 chr18:77673604 PQLC1 -0.34 -8.19 -0.31 1.41e-15 Schizophrenia; BRCA cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg04317338 chr11:64019027 PLCB3 0.55 9.46 0.35 5.59e-20 Mean platelet volume; BRCA cis rs11690935 0.843 rs9784070 chr2:172785007 C/T cg13550731 chr2:172543902 DYNC1I2 -0.8 -22.92 -0.67 2.73e-85 Schizophrenia; BRCA cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg23711669 chr6:146136114 FBXO30 -0.79 -18.92 -0.6 1.03e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs5769707 0.609 rs135861 chr22:49998118 A/G cg05373962 chr22:49881684 NA -0.31 -8.57 -0.32 7.96e-17 Monocyte count;Monocyte percentage of white cells; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.19 -0.31 1.47e-15 Total body bone mineral density; BRCA cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.25e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs3857067 0.772 rs10516947 chr4:95110897 A/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA trans rs3857536 0.740 rs4710574 chr6:66890631 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs8062405 0.755 rs111693583 chr16:28583610 C/T cg16576597 chr16:28551801 NUPR1 0.33 9.2 0.34 4.87e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg11168104 chr5:1857477 NA -0.34 -8.88 -0.33 6.75e-18 Cardiovascular disease risk factors; BRCA cis rs17401966 1.000 rs4846210 chr1:10322153 A/G cg15208524 chr1:10270712 KIF1B 0.39 8.43 0.32 2.24e-16 Hepatocellular carcinoma; BRCA cis rs7267979 1.000 rs6132835 chr20:25434667 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg23711669 chr6:146136114 FBXO30 0.8 19.26 0.61 1.59e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg10057126 chr4:77819792 ANKRD56 0.67 15.54 0.52 1.96e-46 Emphysema distribution in smoking; BRCA cis rs6594713 0.717 rs8180416 chr5:112868440 A/G cg12552261 chr5:112820674 MCC 0.48 8.21 0.31 1.22e-15 Brain cytoarchitecture; BRCA cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 13.68 0.48 1.57e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg14582100 chr15:45693742 SPATA5L1 0.37 11.97 0.43 6.19e-30 Homoarginine levels; BRCA cis rs10463316 0.862 rs10062928 chr5:150768355 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.33 -0.31 4.92e-16 Metabolite levels (Pyroglutamine); BRCA cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg12292205 chr6:26970375 C6orf41 -0.81 -19.89 -0.62 7.21e-69 Autism spectrum disorder or schizophrenia; BRCA cis rs2712184 0.729 rs2541397 chr2:217646693 G/A cg05032264 chr2:217675019 NA -0.38 -9.21 -0.34 4.73e-19 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg05340658 chr4:99064831 C4orf37 0.68 17.2 0.56 8.57e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9467711 0.722 rs35825164 chr6:26117404 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 8.69 0.32 3.15e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg17892150 chr10:133769511 PPP2R2D -0.73 -15.5 -0.52 3.03e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12618769 0.625 rs4850877 chr2:99112154 C/T cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs2777491 0.574 rs72739644 chr15:41719706 A/G cg18705301 chr15:41695430 NDUFAF1 -1.08 -24.99 -0.7 1.08e-96 Ulcerative colitis; BRCA cis rs4689388 0.889 rs4629534 chr4:6294124 G/T cg25554036 chr4:6271136 WFS1 0.42 9.97 0.37 7.45e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2882667 0.858 rs6596460 chr5:138414180 G/A cg04439458 chr5:138467593 SIL1 -0.4 -10.68 -0.39 1.25e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6867032 1.000 rs7729761 chr5:2015783 G/T cg26168224 chr5:2018326 NA 0.64 17.71 0.57 2.02e-57 Gut microbiome composition (winter); BRCA cis rs6772849 0.930 rs4857914 chr3:128350684 C/T cg16766828 chr3:128327626 NA -0.38 -8.44 -0.32 2.15e-16 Monocyte percentage of white cells;Monocyte count; BRCA cis rs2046867 0.862 rs57396880 chr3:72844785 G/A cg25664220 chr3:72788482 NA -0.55 -11.39 -0.41 1.72e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg03396347 chr1:1875803 NA 0.47 11.84 0.42 2.19e-29 Body mass index; BRCA cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg05472934 chr7:22766657 IL6 0.54 13.86 0.48 2.28e-38 Lung cancer; BRCA cis rs10751667 0.643 rs7395613 chr11:933873 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.21e-47 Alzheimer's disease (late onset); BRCA cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg13319975 chr6:146136371 FBXO30 -0.34 -8.04 -0.3 4.44e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.47e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.954 rs10005644 chr4:120298477 T/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg13319975 chr6:146136371 FBXO30 0.41 9.44 0.35 7.04e-20 Lobe attachment (rater-scored or self-reported); BRCA trans rs7618501 0.633 rs9861216 chr3:50059339 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.3 -8.23 -0.31 1.04e-15 Intelligence (multi-trait analysis); BRCA cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -8.03 -0.3 4.68e-15 Total body bone mineral density; BRCA cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg05347473 chr6:146136440 FBXO30 0.4 8.13 0.31 2.22e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12995491 0.933 rs13023008 chr2:88530933 G/A cg04511125 chr2:88470314 THNSL2 -0.45 -9.11 -0.34 1.06e-18 Response to metformin (IC50); BRCA cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg05347473 chr6:146136440 FBXO30 0.42 8.47 0.32 1.63e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg00745463 chr17:30367425 LRRC37B -0.54 -8.89 -0.33 6.21e-18 Hip circumference adjusted for BMI; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10819733 chr22:24237672 NA -0.31 -8.75 -0.33 1.84e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg19077165 chr18:44547161 KATNAL2 -0.53 -11.37 -0.41 2.01e-27 Personality dimensions; BRCA cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg26031613 chr14:104095156 KLC1 -0.43 -8.42 -0.32 2.39e-16 Schizophrenia; BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg27170947 chr2:26402098 FAM59B -0.81 -12.91 -0.45 5e-34 Gut microbiome composition (summer); BRCA cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg23719950 chr11:63933701 MACROD1 -0.53 -8.32 -0.31 5.25e-16 Mean platelet volume; BRCA cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.76 0.36 4.52e-21 Menopause (age at onset); BRCA cis rs11190604 1.000 rs10883499 chr10:102232188 T/A cg07080220 chr10:102295463 HIF1AN 0.49 11.11 0.4 2.36e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg11168104 chr5:1857477 NA -0.36 -9.5 -0.35 4.16e-20 Cardiovascular disease risk factors; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs724568 0.508 rs1430773 chr2:67943520 G/A cg17945962 chr2:67939740 NA -0.4 -10.69 -0.39 1.15e-24 Major depressive disorder (broad); BRCA cis rs7707921 0.881 rs1428940 chr5:81447995 A/G cg15871215 chr5:81402204 ATG10 -0.41 -8.56 -0.32 8.18e-17 Breast cancer; BRCA cis rs5766691 0.644 rs6007607 chr22:47529288 C/T cg15757745 chr22:47558489 TBC1D22A 0.43 8.81 0.33 1.18e-17 Longevity; BRCA cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.6 -0.32 6.31e-17 Glomerular filtration rate (creatinine); BRCA cis rs7267979 0.932 rs6115214 chr20:25557426 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.38 -0.31 3.3e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg17724175 chr1:150552817 MCL1 0.25 8.19 0.31 1.4e-15 Tonsillectomy; BRCA cis rs9596863 1.000 rs1977889 chr13:54442809 C/T ch.13.53330881F chr13:54432880 NA -0.48 -7.97 -0.3 7.59e-15 Epilepsy and lamotrigine-induced maculopapular eruptions; BRCA cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.43e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1434579 0.526 rs204547 chr19:44947184 T/C cg15540054 chr19:45004280 ZNF180 -0.42 -8.73 -0.33 2.3e-17 Tuberculosis; BRCA cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.98 -0.3 6.79e-15 Bipolar disorder; BRCA cis rs71636778 0.524 rs78614739 chr1:27174180 C/T cg12203394 chr1:27248618 NUDC 0.53 8.02 0.3 4.94e-15 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs7131987 0.650 rs11050188 chr12:29473108 A/C cg09582351 chr12:29534625 ERGIC2 -0.43 -9.85 -0.36 2.03e-21 QT interval; BRCA cis rs344364 0.511 rs1742463 chr16:1946110 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.54 -9.64 -0.36 1.26e-20 Glomerular filtration rate in chronic kidney disease; BRCA cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.48 -10.85 -0.39 2.82e-25 Cognitive ability; BRCA trans rs11098499 0.863 rs3775847 chr4:120447642 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.28 0.31 7.45e-16 Corneal astigmatism; BRCA trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg08313168 chr12:7315531 NA 0.5 8.09 0.3 2.95e-15 Lung disease severity in cystic fibrosis; BRCA cis rs6785206 0.614 rs2712430 chr3:128337438 A/C cg16766828 chr3:128327626 NA -0.8 -11.66 -0.42 1.34e-28 Lymphocyte percentage of white cells; BRCA cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11890956 chr21:40555474 PSMG1 -0.81 -19.33 -0.61 7.14e-66 Cognitive function; BRCA trans rs4714291 0.802 rs3008833 chr6:39986303 G/A cg02267698 chr19:7991119 CTXN1 -0.46 -9.38 -0.35 1.1e-19 Strep throat; BRCA cis rs1448094 0.549 rs10863085 chr12:86236328 G/A cg19622623 chr12:86230825 RASSF9 -0.29 -8.18 -0.31 1.57e-15 Major depressive disorder; BRCA cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg23711669 chr6:146136114 FBXO30 0.74 15.69 0.53 3.47e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg24642844 chr7:1081250 C7orf50 -0.51 -10.87 -0.4 2.29e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2387326 0.717 rs10829339 chr10:129943681 C/T cg16087940 chr10:129947807 NA -0.45 -7.94 -0.3 8.99e-15 Select biomarker traits; BRCA cis rs9467773 0.967 rs6941022 chr6:26553531 T/C cg11502198 chr6:26597334 ABT1 0.48 9.62 0.36 1.45e-20 Intelligence (multi-trait analysis); BRCA cis rs9611519 0.828 rs28814423 chr22:41452301 G/A cg03806693 chr22:41940476 POLR3H -0.55 -9.67 -0.36 1e-20 Neuroticism; BRCA cis rs9815354 0.812 rs73828254 chr3:41810180 T/A cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg23285459 chr7:2802560 GNA12 -0.38 -9.53 -0.35 3.19e-20 Height; BRCA cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg25237894 chr2:233734115 C2orf82 -0.38 -10.96 -0.4 1.01e-25 Coronary artery disease; BRCA cis rs11030122 0.702 rs10835406 chr11:3992954 G/T cg18678763 chr11:4115507 RRM1 0.35 7.9 0.3 1.19e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.21 -0.41 9.2e-27 Gut microbiome composition (summer); BRCA cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -13.77 -0.48 5.93e-38 Bipolar disorder; BRCA cis rs9790314 0.779 rs1599376 chr3:160900533 C/G cg04691961 chr3:161091175 C3orf57 -0.49 -10.89 -0.4 1.87e-25 Morning vs. evening chronotype; BRCA cis rs514406 0.505 rs269286 chr1:53169018 C/T cg08859206 chr1:53392774 SCP2 0.4 8.8 0.33 1.32e-17 Monocyte count; BRCA cis rs1443512 0.796 rs1822437 chr12:54340077 A/G cg17410650 chr12:54324560 NA 0.44 11.32 0.41 3.42e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg24130564 chr14:104152367 KLC1 -0.39 -8.94 -0.33 4.18e-18 Intelligence (multi-trait analysis); BRCA cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg24450063 chr1:156163899 SLC25A44 1.08 33.86 0.8 1.07e-144 Testicular germ cell tumor; BRCA cis rs709400 0.663 rs28444993 chr14:103930564 T/C cg12935359 chr14:103987150 CKB -0.58 -13.72 -0.48 1.01e-37 Body mass index; BRCA cis rs2737618 0.651 rs2249156 chr1:200083541 A/G cg21825944 chr1:200113062 NR5A2 0.4 9.32 0.35 1.9e-19 Uric acid levels; BRCA cis rs7523050 0.730 rs41279678 chr1:109440215 G/A cg08274380 chr1:109419600 GPSM2 1.18 16.84 0.55 6.47e-53 Fat distribution (HIV); BRCA cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg13298116 chr11:62369859 EML3;MTA2 0.58 13.57 0.47 4.82e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs765787 0.530 rs7167731 chr15:45510900 T/C cg25801113 chr15:45476975 SHF -0.33 -8.26 -0.31 8.31e-16 Uric acid levels; BRCA cis rs7560272 0.501 rs7210 chr2:73957124 A/G cg20560298 chr2:73613845 ALMS1 0.34 8.81 0.33 1.15e-17 Schizophrenia; BRCA cis rs68170813 0.559 rs80341862 chr7:106934731 C/G cg02696742 chr7:106810147 HBP1 -0.52 -8.99 -0.33 2.84e-18 Coronary artery disease; BRCA cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg10523679 chr1:76189770 ACADM 0.91 22.31 0.66 5.55e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7903847 0.544 rs61861865 chr10:99144867 C/G cg20016023 chr10:99160130 RRP12 -0.27 -8.61 -0.32 5.82e-17 Granulocyte percentage of myeloid white cells; BRCA trans rs11098499 0.863 rs9997631 chr4:120469995 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.13 0.31 2.28e-15 Corneal astigmatism; BRCA cis rs7267979 1.000 rs6107033 chr20:25363591 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.27 -0.31 7.68e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs870825 1.000 rs870823 chr4:185588195 G/A cg04058563 chr4:185651563 MLF1IP 0.85 13.85 0.48 2.44e-38 Blood protein levels; BRCA cis rs870825 0.616 rs55674580 chr4:185626605 C/G cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs1577917 0.958 rs11755048 chr6:86514334 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.57 -14.26 -0.49 3.05e-40 Response to antipsychotic treatment; BRCA cis rs2180341 0.960 rs6913424 chr6:127707010 A/C cg27446573 chr6:127587934 RNF146 0.9 21.02 0.64 5.71e-75 Breast cancer; BRCA cis rs6460942 1.000 rs6948314 chr7:12418363 T/A cg06484146 chr7:12443880 VWDE -0.56 -8.27 -0.31 7.87e-16 Coronary artery disease; BRCA cis rs12200560 0.505 rs4240555 chr6:97076274 T/C cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs7772486 0.875 rs2492855 chr6:146296926 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.67 0.5 3.49e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs738322 0.836 rs4821741 chr22:38514745 A/G cg25457927 chr22:38595422 NA -0.31 -10.97 -0.4 8.91e-26 Cutaneous nevi; BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg03609598 chr5:56110824 MAP3K1 -0.45 -8.03 -0.3 4.59e-15 Initial pursuit acceleration; BRCA cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg24250549 chr1:154909240 PMVK 0.63 15.9 0.53 3.18e-48 Prostate cancer; BRCA cis rs875971 0.895 rs778700 chr7:65866450 C/T cg18876405 chr7:65276391 NA 0.56 13.34 0.47 5.75e-36 Aortic root size; BRCA trans rs4714291 0.963 rs1923489 chr6:40023088 T/C cg02267698 chr19:7991119 CTXN1 0.41 7.87 0.3 1.57e-14 Strep throat; BRCA cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg11266682 chr4:10021025 SLC2A9 -0.41 -10.83 -0.39 3.35e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7264396 0.690 rs2425180 chr20:34447160 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.45 -0.52 5.35e-46 Total cholesterol levels; BRCA cis rs3008870 0.583 rs3008861 chr1:67396222 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.88 16.4 0.54 1.06e-50 Lymphocyte percentage of white cells; BRCA cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg18850127 chr7:39170497 POU6F2 0.55 12.09 0.43 1.91e-30 IgG glycosylation; BRCA cis rs7267979 1.000 rs4815411 chr20:25350223 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.33 -0.35 1.72e-19 Liver enzyme levels (alkaline phosphatase); BRCA trans rs7200543 0.583 rs4985149 chr16:15147338 A/T cg24683922 chr1:11983373 KIAA2013 -0.36 -8.33 -0.31 4.99e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg02734326 chr4:10020555 SLC2A9 0.4 8.72 0.33 2.41e-17 Bone mineral density; BRCA cis rs9325144 0.600 rs7312522 chr12:38730423 A/G cg26384229 chr12:38710491 ALG10B 0.47 12.22 0.44 5.41e-31 Morning vs. evening chronotype; BRCA cis rs367943 0.799 rs13154055 chr5:112971516 A/T cg12552261 chr5:112820674 MCC 0.5 9.9 0.36 1.3e-21 Type 2 diabetes; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.1e-19 Total body bone mineral density; BRCA cis rs6910061 1.000 rs9468452 chr6:11121993 A/G cg27233058 chr6:11094804 LOC221710 0.53 9.57 0.35 2.26e-20 Diabetic kidney disease; BRCA cis rs4803468 1.000 rs1043413 chr19:41939297 C/G cg09537434 chr19:41945824 ATP5SL 1.03 25.65 0.71 2.69e-100 Height; BRCA cis rs5997397 0.967 rs5762777 chr22:29150044 T/C cg02153584 chr22:29168773 CCDC117 0.48 10.55 0.39 4.45e-24 Red cell distribution width; BRCA cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.87 0.56 4.31e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4727443 1.000 rs4727443 chr7:99593346 C/A cg22004693 chr7:99632812 ZKSCAN1 0.39 8.93 0.33 4.62e-18 Interstitial lung disease; BRCA cis rs6545883 0.929 rs3732171 chr2:61749690 C/T cg15711740 chr2:61764176 XPO1 -0.53 -13.56 -0.47 5.12e-37 Tuberculosis; BRCA cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.67 0.42 1.12e-28 Schizophrenia; BRCA cis rs1499614 1.000 rs2707828 chr7:66171377 G/A cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA trans rs3857536 0.741 rs9363558 chr6:66937260 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs71636778 0.543 rs10493037 chr1:27248645 A/G cg12203394 chr1:27248618 NUDC 0.61 9.5 0.35 4.25e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs4589502 1.000 rs16950284 chr15:67154184 A/G cg09911534 chr15:67153556 NA 0.67 10.41 0.38 1.45e-23 Lung cancer (smoking interaction); BRCA cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg19717773 chr7:2847554 GNA12 -0.41 -8.99 -0.34 2.68e-18 Height; BRCA cis rs2635047 0.934 rs11663321 chr18:44622704 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 8.35 0.31 4.16e-16 Educational attainment; BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.59 9.37 0.35 1.2e-19 Renal function-related traits (BUN); BRCA cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg19077165 chr18:44547161 KATNAL2 -0.58 -12.97 -0.46 2.58e-34 Personality dimensions; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg08888203 chr3:10149979 C3orf24 -0.63 -11.79 -0.42 3.46e-29 Alzheimer's disease; BRCA cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg24812749 chr6:127587940 RNF146 0.69 14.95 0.51 1.46e-43 Breast cancer; BRCA cis rs9287719 0.967 rs2110778 chr2:10748970 A/T cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs4880487 0.853 rs883490 chr10:1249567 G/C cg03183215 chr10:1252341 ADARB2 -0.38 -8.51 -0.32 1.25e-16 Migraine; BRCA cis rs7246967 0.673 rs34174596 chr19:22933519 G/A cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg08219700 chr8:58056026 NA 0.59 9.53 0.35 3.3e-20 Developmental language disorder (linguistic errors); BRCA cis rs2832077 0.883 rs35672956 chr21:30189042 T/C cg24692254 chr21:30365293 RNF160 -0.46 -8.03 -0.3 4.54e-15 Cognitive test performance; BRCA trans rs9291683 0.655 rs3822242 chr4:10094904 T/C cg26043149 chr18:55253948 FECH -0.41 -9.18 -0.34 5.9e-19 Bone mineral density; BRCA cis rs10751667 0.600 rs10794342 chr11:924904 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.77 0.53 1.38e-47 Alzheimer's disease (late onset); BRCA cis rs9986765 1.000 rs10243198 chr7:142822210 C/T cg21852589 chr7:142981689 TMEM139 0.57 10.22 0.37 8.1e-23 Cancer;Dermatomyositis; BRCA cis rs6878727 0.665 rs1363306 chr5:123657899 A/G cg01806427 chr5:123737813 NA -0.35 -8.0 -0.3 5.93e-15 Breast cancer; BRCA cis rs2050392 0.760 rs10826797 chr10:30690376 A/C cg18806716 chr10:30721971 MAP3K8 -0.46 -11.07 -0.4 3.62e-26 Inflammatory bowel disease; BRCA cis rs4481887 0.927 rs4244187 chr1:248493511 T/C cg00666640 chr1:248458726 OR2T12 0.33 8.99 0.34 2.73e-18 Common traits (Other); BRCA cis rs3806843 1.000 rs1030164 chr5:140185272 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.86e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs600806 0.850 rs3768493 chr1:109935505 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.74 -0.33 2.11e-17 Colorectal cancer; BRCA cis rs6964587 0.967 rs7801058 chr7:91784381 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.11 0.31 2.52e-15 Breast cancer; BRCA cis rs2019216 1.000 rs3751916 chr17:21909270 T/C cg22648282 chr17:21454238 C17orf51 -0.35 -8.1 -0.31 2.78e-15 Pelvic organ prolapse; BRCA cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 3.78e-31 Prostate cancer (SNP x SNP interaction); BRCA trans rs7395662 0.570 rs11039737 chr11:48450200 G/A cg15704280 chr7:45808275 SEPT13 -0.46 -8.81 -0.33 1.16e-17 HDL cholesterol; BRCA cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg19761014 chr17:28927070 LRRC37B2 0.56 8.0 0.3 5.79e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.68 0.42 1.1e-28 Homoarginine levels; BRCA cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg08999081 chr20:33150536 PIGU 0.36 9.28 0.34 2.53e-19 Coronary artery disease; BRCA cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11644478 chr21:40555479 PSMG1 0.74 14.89 0.51 3.04e-43 Cognitive function; BRCA cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 13.03 0.46 1.43e-34 Colorectal cancer; BRCA cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg10523679 chr1:76189770 ACADM 0.76 15.96 0.53 1.62e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4243830 1.000 rs12046884 chr1:6594561 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.91 14.09 0.49 1.89e-39 Body mass index; BRCA cis rs2880765 0.835 rs4842886 chr15:86035773 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.5 -0.32 1.32e-16 Coronary artery disease; BRCA cis rs56104184 0.775 rs73061694 chr19:49399978 T/C cg21252483 chr19:49399788 TULP2 -0.51 -10.86 -0.39 2.46e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs9612 1.000 rs3786954 chr19:44272346 A/G cg08581076 chr19:44259116 C19orf61 0.49 9.21 0.34 4.7e-19 Exhaled nitric oxide output; BRCA cis rs7647973 0.626 rs4855846 chr3:49683526 G/A cg07636037 chr3:49044803 WDR6 0.52 8.46 0.32 1.81e-16 Menarche (age at onset); BRCA cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.83 0.39 3.4e-25 Bipolar disorder; BRCA cis rs870825 0.616 rs6810635 chr4:185616859 T/C cg04058563 chr4:185651563 MLF1IP 0.77 16.89 0.56 3.47e-53 Blood protein levels; BRCA cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg20818283 chr2:191399100 TMEM194B -0.39 -8.98 -0.33 2.95e-18 Pulse pressure; BRCA cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg18230493 chr5:56204884 C5orf35 0.62 13.07 0.46 8.87e-35 Initial pursuit acceleration; BRCA cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.59 -10.31 -0.38 3.67e-23 Gut microbiome composition (summer); BRCA cis rs3771570 0.901 rs3771585 chr2:242400723 G/A cg21155796 chr2:242212141 HDLBP 0.51 8.94 0.33 4.18e-18 Prostate cancer; BRCA cis rs8032158 0.963 rs56333939 chr15:56124535 T/C cg02198044 chr15:56286336 NEDD4 -0.38 -9.19 -0.34 5.31e-19 Keloid; BRCA cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg05347473 chr6:146136440 FBXO30 0.43 8.64 0.32 4.67e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg08045932 chr20:61659980 NA 0.5 11.46 0.41 8.76e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18301423 chr5:131593218 PDLIM4 0.31 8.19 0.31 1.39e-15 Breast cancer; BRCA cis rs36052053 0.908 rs13203020 chr6:109584645 C/A cg12927641 chr6:109611667 NA -0.5 -7.95 -0.3 8.31e-15 Red cell distribution width; BRCA cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg17971929 chr21:40555470 PSMG1 -0.71 -15.88 -0.53 4.02e-48 Cognitive function; BRCA cis rs3768617 0.510 rs10752904 chr1:183101038 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA trans rs11098499 1.000 rs11098500 chr4:120219239 T/A cg25214090 chr10:38739885 LOC399744 0.5 10.91 0.4 1.53e-25 Corneal astigmatism; BRCA cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg04450456 chr4:17643702 FAM184B -0.32 -9.38 -0.35 1.18e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3820928 0.967 rs2396435 chr2:227778397 G/A cg11843606 chr2:227700838 RHBDD1 -0.39 -8.55 -0.32 8.87e-17 Pulmonary function; BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.08 0.64 2.75e-75 Gut microbiome composition (summer); BRCA trans rs6598955 0.671 rs10493030 chr1:26561856 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs4319547 0.956 rs7397990 chr12:123119472 T/C cg05707623 chr12:122985044 ZCCHC8 -0.42 -8.77 -0.33 1.65e-17 Body mass index; BRCA cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg01028140 chr2:1542097 TPO -0.81 -16.05 -0.54 5.9e-49 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1707322 0.716 rs6699444 chr1:46135120 G/C cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -12.93 -0.46 3.89e-34 Bipolar disorder and schizophrenia; BRCA cis rs9470366 0.509 rs4713996 chr6:36629714 C/T cg08179530 chr6:36648295 CDKN1A -0.54 -12.41 -0.44 7.68e-32 QRS duration; BRCA cis rs2933343 0.729 rs1683780 chr3:128640239 C/T cg11901034 chr3:128598214 ACAD9 -0.37 -8.94 -0.33 4.19e-18 IgG glycosylation; BRCA cis rs77972916 0.611 rs6709988 chr2:43601317 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -10.54 -0.38 4.57e-24 Granulocyte percentage of myeloid white cells; BRCA cis rs10911232 0.507 rs10797822 chr1:183017769 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.92 0.56 2.57e-53 Hypertriglyceridemia; BRCA cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.29 0.31 6.86e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA trans rs2197308 0.740 rs10880619 chr12:37922720 T/C cg06521331 chr12:34319734 NA -0.54 -9.58 -0.35 2.16e-20 Morning vs. evening chronotype; BRCA cis rs8017423 0.647 rs12883357 chr14:90815032 A/G cg04374321 chr14:90722782 PSMC1 -0.52 -12.61 -0.45 1.01e-32 Mortality in heart failure; BRCA cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg26647111 chr11:31128758 NA -0.44 -9.62 -0.36 1.5e-20 Red blood cell count; BRCA cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11890956 chr21:40555474 PSMG1 -0.82 -19.57 -0.61 3.6e-67 Cognitive function; BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.17 0.31 1.61e-15 Tonsillectomy; BRCA cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.43 -9.13 -0.34 8.96e-19 IgG glycosylation; BRCA cis rs1018836 0.884 rs13279263 chr8:91648780 T/C cg16814680 chr8:91681699 NA -0.49 -10.37 -0.38 2.17e-23 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg20503657 chr10:835505 NA 1.05 18.68 0.59 1.79e-62 Eosinophil percentage of granulocytes; BRCA cis rs10883723 0.810 rs7069356 chr10:104254359 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg05347473 chr6:146136440 FBXO30 0.53 10.36 0.38 2.32e-23 Lobe attachment (rater-scored or self-reported); BRCA trans rs79911532 0.515 rs17148983 chr7:75649821 C/G cg19862616 chr7:65841803 NCRNA00174 0.62 8.66 0.32 3.73e-17 Mononucleosis; BRCA trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.26 0.44 3.39e-31 Corneal astigmatism; BRCA cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg16339924 chr4:17578868 LAP3 0.57 13.74 0.48 7.85e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg10820045 chr2:198174542 NA -0.46 -10.88 -0.4 2.11e-25 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg10370574 chr19:1840461 REXO1 0.37 8.58 0.32 7.21e-17 Bipolar disorder; BRCA cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.67 11.74 0.42 5.99e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg11764359 chr7:65958608 NA -0.7 -14.8 -0.51 8.13e-43 Aortic root size; BRCA cis rs12950390 0.853 rs56387656 chr17:45860189 C/G cg03474202 chr17:45855739 NA -0.46 -12.23 -0.44 4.53e-31 IgG glycosylation; BRCA cis rs2463822 0.748 rs2513053 chr11:62109473 T/A cg06239285 chr11:62104954 ASRGL1 0.67 11.15 0.4 1.7e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7301826 0.651 rs10744483 chr12:131298206 C/A cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 3e-37 Plasma plasminogen activator levels; BRCA cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg16405210 chr4:1374714 KIAA1530 -0.92 -20.97 -0.64 1.12e-74 Longevity; BRCA cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.4 0.41 1.56e-27 Height; BRCA cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA cis rs919433 0.617 rs10931793 chr2:198577585 G/A cg00792783 chr2:198669748 PLCL1 -0.44 -9.73 -0.36 5.78e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs3818285 0.504 rs4917547 chr10:111652285 T/C cg00817464 chr10:111662876 XPNPEP1 -0.34 -8.83 -0.33 9.8e-18 Superior crus of antihelix expression; BRCA cis rs8014204 0.762 rs12889665 chr14:75234830 T/G cg06637938 chr14:75390232 RPS6KL1 0.42 8.69 0.33 3e-17 Caffeine consumption; BRCA cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg20503657 chr10:835505 NA 1.02 17.81 0.58 6.43e-58 Eosinophil percentage of granulocytes; BRCA cis rs9283706 0.608 rs10053537 chr5:66332543 T/C cg11590213 chr5:66331682 MAST4 0.37 7.89 0.3 1.32e-14 Coronary artery disease; BRCA cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs7520050 0.966 rs6700597 chr1:46284246 G/A cg24296786 chr1:45957014 TESK2 0.44 9.85 0.36 2.07e-21 Red blood cell count;Reticulocyte count; BRCA cis rs921968 0.565 rs2272191 chr2:219609776 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -10.97 -0.4 8.68e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs10644111 1 rs10644111 chr7:91652178 A/AAAC cg17063962 chr7:91808500 NA 0.57 13.6 0.47 3.52e-37 Breast cancer; BRCA cis rs3768617 0.510 rs2296290 chr1:183079412 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg11905131 chr22:24372483 LOC391322 0.55 12.22 0.44 5.47e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2041840 0.597 rs10865124 chr2:37576553 A/G cg25727520 chr2:37576821 QPCT -0.29 -8.08 -0.3 3.16e-15 Chronic lymphocytic leukemia; BRCA cis rs9393692 0.676 rs1543681 chr6:26187783 G/T cg13736514 chr6:26305472 NA -0.33 -10.16 -0.37 1.45e-22 Educational attainment; BRCA cis rs4908768 0.501 rs6702060 chr1:8607024 G/A cg20416874 chr1:8611966 RERE -0.29 -8.32 -0.31 5.26e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg02297831 chr4:17616191 MED28 0.38 8.53 0.32 1.03e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7520050 0.966 rs6656992 chr1:46333068 C/G cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7833986 0.501 rs72653981 chr8:57027814 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.69 12.88 0.45 6.83e-34 Height; BRCA cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1371614 0.632 rs6708148 chr2:27167320 A/G cg00617064 chr2:27272375 NA -0.33 -8.75 -0.33 1.85e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg25319279 chr11:5960081 NA -0.43 -8.38 -0.31 3.29e-16 DNA methylation (variation); BRCA cis rs752010 0.871 rs2038976 chr1:42094498 A/G cg06885757 chr1:42089581 HIVEP3 0.3 10.34 0.38 2.82e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg25019033 chr10:957182 NA -0.41 -7.9 -0.3 1.24e-14 Eosinophil percentage of granulocytes; BRCA cis rs16854884 0.657 rs6791078 chr3:143736876 A/G cg06585982 chr3:143692056 C3orf58 0.43 8.99 0.33 2.87e-18 Economic and political preferences (feminism/equality); BRCA cis rs9790314 1.000 rs4350933 chr3:160955879 G/T cg03342759 chr3:160939853 NMD3 -0.65 -14.89 -0.51 3.03e-43 Morning vs. evening chronotype; BRCA cis rs7617773 0.780 rs13067450 chr3:48337206 C/T cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg05868516 chr6:26286170 HIST1H4H 0.49 11.03 0.4 4.95e-26 Educational attainment; BRCA cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg19678392 chr7:94953810 PON1 -0.41 -8.77 -0.33 1.66e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9287719 0.967 rs10929688 chr2:10756650 T/C cg00105475 chr2:10696890 NA 0.44 10.27 0.38 5.22e-23 Prostate cancer; BRCA cis rs17376456 0.877 rs10059630 chr5:93459807 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.14 0.31 2.1e-15 Diabetic retinopathy; BRCA cis rs7809950 0.773 rs2237668 chr7:107050209 A/G cg23024343 chr7:107201750 COG5 -0.49 -10.11 -0.37 2.13e-22 Coronary artery disease; BRCA cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg08704250 chr15:31115839 NA -0.36 -8.87 -0.33 7.53e-18 Huntington's disease progression; BRCA cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg12011299 chr4:100065546 ADH4 0.48 10.82 0.39 3.58e-25 Smoking initiation; BRCA cis rs9435341 0.965 rs3108680 chr1:107572997 T/C cg09367891 chr1:107599246 PRMT6 0.4 7.96 0.3 7.79e-15 Facial morphology (factor 21, depth of nasal alae); BRCA trans rs4596713 0.538 rs7048095 chr9:71745663 G/A cg16512924 chr15:28394682 HERC2 0.4 9.45 0.35 6.24e-20 Headache; BRCA cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg01579765 chr21:45077557 HSF2BP -0.41 -11.01 -0.4 5.95e-26 Mean corpuscular volume; BRCA cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg09658497 chr7:2847517 GNA12 -0.41 -8.61 -0.32 5.63e-17 Height; BRCA trans rs7786808 0.579 rs12669482 chr7:158188813 G/A cg02030672 chr11:45687055 CHST1 0.48 10.53 0.38 4.92e-24 Obesity-related traits; BRCA cis rs7246967 0.673 rs36029703 chr19:22906188 C/A cg23217946 chr19:22817039 ZNF492 0.51 9.41 0.35 8.44e-20 Bronchopulmonary dysplasia; BRCA cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg06212747 chr3:49208901 KLHDC8B -0.49 -10.12 -0.37 2.07e-22 Parkinson's disease; BRCA cis rs13046373 0.535 rs1911571 chr21:32031538 A/C cg27071517 chr21:31768726 KRTAP13-1 0.29 8.13 0.31 2.24e-15 HDL cholesterol; BRCA cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.51 11.58 0.42 2.76e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.18 0.34 5.98e-19 Platelet count; BRCA cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg01877450 chr7:97915802 BRI3 -0.39 -8.77 -0.33 1.58e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg18876405 chr7:65276391 NA -0.5 -11.23 -0.41 7.86e-27 Aortic root size; BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26314531 chr2:26401878 FAM59B -0.61 -10.26 -0.38 5.75e-23 Gut microbiome composition (summer); BRCA cis rs6840360 0.571 rs7692700 chr4:152552797 C/T cg22705602 chr4:152727874 NA -0.35 -8.58 -0.32 7.06e-17 Intelligence (multi-trait analysis); BRCA cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg00012203 chr2:219082015 ARPC2 0.47 9.18 0.34 5.9e-19 Ulcerative colitis; BRCA cis rs4363385 0.818 rs3795381 chr1:153004848 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.59 -0.32 6.84e-17 Inflammatory skin disease; BRCA cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg13319975 chr6:146136371 FBXO30 -0.37 -8.38 -0.31 3.41e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs17270561 0.636 rs6456694 chr6:25712894 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.79 0.33 1.36e-17 Iron status biomarkers; BRCA cis rs8062405 1.000 rs28403629 chr16:28854769 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.9 0.33 5.77e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs939658 0.875 rs2177057 chr15:79441441 G/C cg17916960 chr15:79447300 NA -0.43 -10.98 -0.4 8.11e-26 Refractive error; BRCA cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.25 -0.41 6.34e-27 IgG glycosylation; BRCA cis rs7246657 0.722 rs2972447 chr19:38129736 C/T cg23950597 chr19:37808831 NA 0.52 8.87 0.33 7.37e-18 Coronary artery calcification; BRCA cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg23711669 chr6:146136114 FBXO30 -0.79 -18.87 -0.6 1.77e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs12760731 0.641 rs12038910 chr1:178444907 C/T cg00404053 chr1:178313656 RASAL2 0.57 8.29 0.31 6.67e-16 Obesity-related traits; BRCA cis rs10504073 0.647 rs12546839 chr8:50009020 C/T cg00325661 chr8:49890786 NA 0.44 12.4 0.44 8.53e-32 Blood metabolite ratios; BRCA cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg05340658 chr4:99064831 C4orf37 0.58 11.71 0.42 7.64e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.79e-41 Motion sickness; BRCA trans rs7980799 0.935 rs2389194 chr12:33529164 A/G cg26384229 chr12:38710491 ALG10B -0.4 -8.47 -0.32 1.65e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs11671005 0.695 rs8106061 chr19:58917990 G/C cg26874164 chr19:58962979 ZNF324B 0.68 15.24 0.52 5.87e-45 Mean platelet volume; BRCA cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg18867708 chr6:26865862 GUSBL1 0.42 8.26 0.31 8.42e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1707322 1.000 rs6687301 chr1:46382852 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.43e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9790314 0.967 rs463928 chr3:161087734 A/T cg03342759 chr3:160939853 NMD3 -0.52 -11.16 -0.4 1.47e-26 Morning vs. evening chronotype; BRCA cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg01689657 chr7:91764605 CYP51A1 0.22 8.17 0.31 1.7e-15 Breast cancer; BRCA cis rs4481887 0.927 rs6671702 chr1:248482851 G/A cg13385794 chr1:248469461 NA 0.27 7.94 0.3 8.8e-15 Common traits (Other); BRCA cis rs6546550 0.869 rs6712827 chr2:70156540 C/G cg02498382 chr2:70120550 SNRNP27 -0.51 -11.22 -0.41 8.33e-27 Prevalent atrial fibrillation; BRCA cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg11584989 chr19:19387371 SF4 0.66 14.26 0.49 2.94e-40 Bipolar disorder; BRCA cis rs1448094 0.511 rs10506918 chr12:86227913 A/G cg19622623 chr12:86230825 RASSF9 0.35 9.76 0.36 4.35e-21 Major depressive disorder; BRCA trans rs8002861 0.664 rs2218497 chr13:44428793 G/A cg17145862 chr1:211918768 LPGAT1 0.47 10.77 0.39 5.62e-25 Leprosy; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg00166722 chr3:10149974 C3orf24 0.6 12.19 0.43 6.74e-31 Alzheimer's disease; BRCA trans rs2204008 0.805 rs11522896 chr12:38234427 T/C cg06521331 chr12:34319734 NA -0.52 -9.37 -0.35 1.22e-19 Bladder cancer; BRCA cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg04166393 chr7:2884313 GNA12 0.4 8.81 0.33 1.19e-17 Height; BRCA cis rs11072805 1 rs11072805 chr15:79078518 T/C cg04896959 chr15:78267971 NA 0.37 8.59 0.32 6.68e-17 Post bronchodilator FEV1/FVC ratio; BRCA cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg06092702 chr1:163392909 NA -0.32 -8.6 -0.32 6.23e-17 Motion sickness; BRCA cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.85 0.39 2.86e-25 Rheumatoid arthritis; BRCA cis rs10851411 0.606 rs11635889 chr15:42818987 T/C cg21293051 chr15:42870591 STARD9 0.51 8.45 0.32 1.92e-16 Glucose homeostasis traits; BRCA cis rs12472274 0.941 rs11677230 chr2:239092054 T/C cg17459225 chr2:239074497 NA 0.64 13.25 0.46 1.35e-35 Phospholipid levels (plasma); BRCA cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg13010199 chr12:38710504 ALG10B 0.4 8.67 0.32 3.56e-17 Bladder cancer; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26314531 chr2:26401878 FAM59B 0.9 15.14 0.51 1.7e-44 Gut microbiome composition (summer); BRCA cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg01236616 chr12:121019343 POP5 1.24 27.85 0.74 2.17e-112 Type 1 diabetes nephropathy; BRCA cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.26e-28 Body mass index; BRCA trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.35 8.58 0.32 7.37e-17 Resting heart rate; BRCA cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg26597838 chr10:835615 NA -0.51 -9.36 -0.35 1.33e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs9467773 1.000 rs6925895 chr6:26572165 G/T cg09904177 chr6:26538194 HMGN4 0.55 17.64 0.57 4.82e-57 Intelligence (multi-trait analysis); BRCA cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.02 14.72 0.5 1.9e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2070488 0.965 rs3762791 chr3:38568828 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -19.37 -0.61 4.25e-66 Electrocardiographic conduction measures; BRCA cis rs10089 1.000 rs17764954 chr5:127514436 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 13.24 0.46 1.53e-35 Ileal carcinoids; BRCA cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.88 0.33 6.96e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg21475434 chr5:93447410 FAM172A 0.69 8.72 0.33 2.43e-17 Diabetic retinopathy; BRCA cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.12e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 0.666 rs12209856 chr6:25793673 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 9.21 0.34 4.61e-19 Iron status biomarkers; BRCA cis rs1868673 1.000 rs9813752 chr3:150151120 G/A cg04908077 chr3:150187338 NA -0.33 -8.99 -0.34 2.8e-18 Waist circumference; BRCA cis rs7647973 1.000 rs10155014 chr3:49432321 C/T cg07636037 chr3:49044803 WDR6 0.75 16.38 0.54 1.31e-50 Menarche (age at onset); BRCA cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg13256891 chr4:100009986 ADH5 0.47 9.06 0.34 1.52e-18 Alcohol dependence; BRCA trans rs1994135 0.669 rs10844628 chr12:33697065 T/C cg26384229 chr12:38710491 ALG10B 0.4 8.58 0.32 7.38e-17 Resting heart rate; BRCA cis rs17854409 0.764 rs16983293 chr20:61479056 A/G cg06598544 chr20:61472147 COL9A3 -0.82 -8.11 -0.31 2.6e-15 Obesity-related traits; BRCA cis rs2479724 0.870 rs6902650 chr6:41764080 G/A cg17623882 chr6:41773611 USP49 0.35 9.42 0.35 8.37e-20 Menarche (age at onset); BRCA cis rs2073300 0.609 rs17757228 chr20:23351288 A/T cg12062639 chr20:23401060 NAPB 0.94 13.51 0.47 9.47e-37 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs3849570 1.000 rs3860595 chr3:81811784 A/G cg07356753 chr3:81810745 GBE1 -0.42 -10.02 -0.37 4.68e-22 Waist circumference;Body mass index; BRCA cis rs6977660 0.607 rs10243965 chr7:19797893 G/A cg05791153 chr7:19748676 TWISTNB 0.58 10.81 0.39 3.94e-25 Thyroid stimulating hormone; BRCA cis rs12050794 0.671 rs62022788 chr15:72559326 T/G cg16672083 chr15:72433130 SENP8 0.61 14.65 0.5 3.9e-42 Metabolite levels (HVA/MHPG ratio); BRCA cis rs7572733 0.534 rs700664 chr2:198671145 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.27 0.38 5.27e-23 Dermatomyositis; BRCA cis rs1448094 0.512 rs7313278 chr12:86250263 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.81e-19 Major depressive disorder; BRCA cis rs10992471 0.702 rs10820967 chr9:95101729 C/G cg14631576 chr9:95140430 CENPP -0.37 -8.76 -0.33 1.69e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg15704280 chr7:45808275 SEPT13 0.54 9.13 0.34 8.85e-19 Axial length; BRCA cis rs1113500 0.897 rs4628530 chr1:108638708 T/G cg06207961 chr1:108661230 NA 0.44 10.84 0.39 2.89e-25 Growth-regulated protein alpha levels; BRCA cis rs6867032 0.958 rs4975795 chr5:2015390 G/A cg26168224 chr5:2018326 NA 0.65 18.31 0.59 1.61e-60 Gut microbiome composition (winter); BRCA cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg01877450 chr7:97915802 BRI3 -0.39 -8.67 -0.32 3.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs977987 0.778 rs4888412 chr16:75443196 A/G cg03315344 chr16:75512273 CHST6 0.53 12.52 0.44 2.54e-32 Dupuytren's disease; BRCA cis rs3820928 1.000 rs61067328 chr2:227761256 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.81 -0.33 1.18e-17 Pulmonary function; BRCA cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg13010199 chr12:38710504 ALG10B 0.42 8.1 0.31 2.86e-15 Bladder cancer; BRCA cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11644478 chr21:40555479 PSMG1 0.87 20.27 0.63 6.32e-71 Cognitive function; BRCA cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg11764359 chr7:65958608 NA 0.75 16.78 0.55 1.26e-52 Aortic root size; BRCA cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg25358565 chr5:93447407 FAM172A 1.14 19.34 0.61 5.82e-66 Diabetic retinopathy; BRCA cis rs2288073 0.965 rs10173949 chr2:24410256 A/C cg26838691 chr2:24397539 C2orf84 -0.48 -8.67 -0.32 3.46e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs1949733 0.582 rs61258495 chr4:8534017 G/A cg11789530 chr4:8429930 ACOX3 -0.49 -11.57 -0.42 3.09e-28 Response to antineoplastic agents; BRCA cis rs72781680 0.898 rs12620558 chr2:23936022 G/A cg20701182 chr2:24300061 SF3B14 0.62 8.83 0.33 1e-17 Lymphocyte counts; BRCA cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg01579765 chr21:45077557 HSF2BP -0.4 -10.84 -0.39 2.9e-25 Mean corpuscular volume; BRCA cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.68e-18 Motion sickness; BRCA cis rs7267979 1.000 rs404394 chr20:25447896 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.4 0.35 9.69e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg19539972 chr4:7069911 GRPEL1 0.6 12.05 0.43 2.83e-30 Monocyte percentage of white cells; BRCA cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg13319975 chr6:146136371 FBXO30 0.41 9.35 0.35 1.49e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.818 rs10788854 chr1:153002320 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.32 -0.31 5.19e-16 Inflammatory skin disease; BRCA cis rs13418410 0.539 rs35866672 chr2:33842174 G/A cg04131969 chr2:33951647 MYADML -0.55 -10.87 -0.39 2.35e-25 Non-response to antidepressants and depression; BRCA cis rs881375 0.967 rs758959 chr9:123676699 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.42 0.32 2.43e-16 Rheumatoid arthritis; BRCA cis rs8005677 1.000 rs4981449 chr14:23388871 C/G cg01529538 chr14:23388837 RBM23 0.42 11.48 0.41 7.01e-28 Cognitive ability (multi-trait analysis); BRCA cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg06108461 chr20:60628389 TAF4 -0.73 -15.3 -0.52 3e-45 Body mass index; BRCA cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg11833968 chr6:79620685 NA -0.46 -10.15 -0.37 1.5e-22 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.918 rs17817359 chr4:100054197 G/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs1997103 1.000 rs6976824 chr7:55396115 A/C cg17469321 chr7:55412551 NA 0.48 8.98 0.33 3.09e-18 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1018836 0.892 rs4735224 chr8:91567046 C/A cg16814680 chr8:91681699 NA -0.57 -12.35 -0.44 1.39e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg23205692 chr1:25664452 TMEM50A 0.43 10.28 0.38 4.78e-23 Erythrocyte sedimentation rate; BRCA cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -8.96 -0.33 3.45e-18 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg26384229 chr12:38710491 ALG10B 0.76 16.99 0.56 1.09e-53 Bladder cancer; BRCA cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg05340658 chr4:99064831 C4orf37 -0.67 -16.97 -0.56 1.27e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg17063962 chr7:91808500 NA 0.54 12.62 0.45 9.63e-33 Breast cancer; BRCA cis rs11955398 0.563 rs1117676 chr5:60034824 G/A cg02684056 chr5:59996105 DEPDC1B -0.38 -9.11 -0.34 1.08e-18 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg24069376 chr3:38537580 EXOG -0.33 -9.43 -0.35 7.59e-20 Electrocardiographic conduction measures; BRCA cis rs6570726 0.902 rs406979 chr6:145838983 G/T cg23711669 chr6:146136114 FBXO30 0.65 15.41 0.52 8.21e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs2764980 1.000 rs11251794 chr10:3283931 C/T cg18054281 chr10:3284093 NA -0.32 -8.04 -0.3 4.25e-15 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs8028182 0.636 rs7495610 chr15:75784441 T/C cg20655648 chr15:75932815 IMP3 0.42 8.09 0.3 2.91e-15 Sudden cardiac arrest; BRCA cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.32 0.38 3.49e-23 Motion sickness; BRCA cis rs738322 0.600 rs6001031 chr22:38556260 G/T cg25457927 chr22:38595422 NA 0.35 12.9 0.45 5.54e-34 Cutaneous nevi; BRCA cis rs2882667 0.690 rs288028 chr5:138221989 C/G cg04439458 chr5:138467593 SIL1 -0.33 -8.09 -0.3 2.9e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg16606324 chr3:10149918 C3orf24 0.54 10.48 0.38 8.25e-24 Alzheimer's disease; BRCA cis rs11229555 0.574 rs11229454 chr11:58203682 T/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg25358565 chr5:93447407 FAM172A 1.18 17.27 0.56 3.74e-55 Diabetic retinopathy; BRCA cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg15017067 chr4:17643749 FAM184B 0.32 9.66 0.36 1.06e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9868809 0.505 rs13434258 chr3:48738491 T/C cg07636037 chr3:49044803 WDR6 -0.57 -7.86 -0.3 1.61e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.22 -0.37 8.01e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs524281 0.861 rs7943911 chr11:65943054 G/A cg16950941 chr11:66035639 RAB1B -0.37 -7.84 -0.3 1.92e-14 Electroencephalogram traits; BRCA cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg12379764 chr21:47803548 PCNT -0.4 -9.12 -0.34 9.98e-19 Testicular germ cell tumor; BRCA cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg09021430 chr5:549028 NA -0.67 -15.13 -0.51 1.98e-44 Lung disease severity in cystic fibrosis; BRCA cis rs35146811 0.735 rs1727130 chr7:99811464 C/G cg13334819 chr7:99746414 C7orf59 0.34 8.05 0.3 4.16e-15 Coronary artery disease; BRCA cis rs208520 0.754 rs7753158 chr6:66875633 A/C cg07460842 chr6:66804631 NA -0.94 -17.59 -0.57 8.51e-57 Exhaled nitric oxide output; BRCA cis rs548181 0.736 rs1941558 chr11:125425606 C/T cg03464685 chr11:125439445 EI24 1.12 17.48 0.57 3.36e-56 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs4780401 0.609 rs8063099 chr16:11806714 T/G cg01061890 chr16:11836724 TXNDC11 -0.55 -13.07 -0.46 9.31e-35 Rheumatoid arthritis; BRCA cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg15485101 chr11:133734466 NA 0.41 9.71 0.36 6.96e-21 Childhood ear infection; BRCA cis rs344364 0.511 rs2982447 chr16:1947413 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 0.52 9.05 0.34 1.71e-18 Glomerular filtration rate in chronic kidney disease; BRCA cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.89 0.6 1.4e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs796364 0.806 rs1509832 chr2:200874443 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.23 0.41 7.85e-27 Schizophrenia; BRCA cis rs4930561 0.765 rs4930229 chr11:67944080 G/A cg16338278 chr11:67432957 ALDH3B2 0.43 8.81 0.33 1.13e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.15 0.4 1.74e-26 Rheumatoid arthritis; BRCA cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg06064525 chr11:970664 AP2A2 -0.49 -16.07 -0.54 4.92e-49 Alzheimer's disease (late onset); BRCA cis rs4805272 0.539 rs1075733 chr19:29324460 C/T cg04546413 chr19:29218101 NA 0.44 8.16 0.31 1.83e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg05340658 chr4:99064831 C4orf37 0.61 14.7 0.5 2.43e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg21747090 chr2:27597821 SNX17 -0.45 -9.7 -0.36 7.9e-21 Total body bone mineral density; BRCA cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg21573476 chr21:45109991 RRP1B -0.36 -9.48 -0.35 4.82e-20 Mean corpuscular volume; BRCA cis rs3784262 0.565 rs9635350 chr15:58298412 G/A cg12031962 chr15:58353849 ALDH1A2 0.32 8.5 0.32 1.3e-16 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.04 -0.4 4.7e-26 IgG glycosylation; BRCA cis rs780094 0.544 rs780110 chr2:27685388 G/A cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.84 -0.3 1.92e-14 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs3857067 0.680 rs1509946 chr4:95109078 G/T cg11021082 chr4:95130006 SMARCAD1 -0.38 -9.2 -0.34 4.82e-19 QT interval; BRCA cis rs6456156 0.565 rs6921588 chr6:167494397 G/T cg07741184 chr6:167504864 NA 0.36 9.95 0.37 9.05e-22 Primary biliary cholangitis; BRCA cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg00074818 chr8:8560427 CLDN23 0.38 8.45 0.32 2.02e-16 Obesity-related traits; BRCA cis rs11098499 0.874 rs6826823 chr4:120112098 G/C cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.65e-26 Corneal astigmatism; BRCA cis rs9815354 0.812 rs56728371 chr3:41999381 T/A cg03022575 chr3:42003672 ULK4 0.65 9.34 0.35 1.53e-19 Pulse pressure;Diastolic blood pressure; BRCA cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg05347473 chr6:146136440 FBXO30 -0.41 -8.05 -0.3 3.92e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9393777 0.513 rs61240102 chr6:27124904 G/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.33 -8.77 -0.33 1.56e-17 Intelligence (multi-trait analysis); BRCA cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg22903471 chr2:27725779 GCKR -0.34 -8.21 -0.31 1.22e-15 Total body bone mineral density; BRCA trans rs61931739 0.534 rs11053016 chr12:34104372 C/T cg26384229 chr12:38710491 ALG10B 0.68 14.16 0.49 8.91e-40 Morning vs. evening chronotype; BRCA cis rs6963495 0.585 rs1728653 chr7:105191335 A/G cg19920283 chr7:105172520 RINT1 0.57 11.4 0.41 1.56e-27 Bipolar disorder (body mass index interaction); BRCA cis rs2180341 0.961 rs7774468 chr6:127592501 G/C cg24812749 chr6:127587940 RNF146 0.88 20.44 0.63 8.18e-72 Breast cancer; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg22920501 chr2:26401640 FAM59B 0.94 16.57 0.55 1.46e-51 Gut microbiome composition (summer); BRCA cis rs9787249 0.957 rs56064244 chr1:40213890 C/T cg02773041 chr1:40204384 PPIE 0.43 9.25 0.34 3.34e-19 Blood protein levels; BRCA cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs2559856 1.000 rs2695299 chr12:102082664 G/A cg12924262 chr12:102091054 CHPT1 0.35 7.94 0.3 8.88e-15 Blood protein levels; BRCA cis rs6973256 0.897 rs9656424 chr7:133325031 A/T cg07491979 chr7:133331646 EXOC4 -0.38 -8.8 -0.33 1.28e-17 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg06064525 chr11:970664 AP2A2 0.48 16.27 0.54 4.42e-50 Alzheimer's disease (late onset); BRCA cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14442939 chr10:27389572 ANKRD26 0.68 9.37 0.35 1.22e-19 Breast cancer; BRCA cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg12292205 chr6:26970375 C6orf41 -0.49 -8.07 -0.3 3.56e-15 Intelligence (multi-trait analysis); BRCA cis rs1568889 1.000 rs61889026 chr11:28274803 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 13.27 0.46 1.18e-35 Bipolar disorder; BRCA cis rs9649465 1.000 rs2299983 chr7:123356642 C/G cg04330084 chr7:123175371 IQUB -0.33 -9.01 -0.34 2.32e-18 Migraine; BRCA cis rs2302729 0.578 rs2302728 chr12:2774668 A/C cg19945202 chr12:2788847 CACNA1C 0.43 9.63 0.36 1.38e-20 Sleep quality; BRCA cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg01028140 chr2:1542097 TPO -0.56 -11.48 -0.41 7.52e-28 IgG glycosylation; BRCA trans rs75804782 0.641 rs72987304 chr2:239345532 C/T cg01134436 chr17:81009848 B3GNTL1 0.78 9.79 0.36 3.57e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs2979489 1.000 rs2979469 chr8:30285091 C/G cg26383811 chr8:30366931 RBPMS 0.47 11.07 0.4 3.53e-26 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs17767294 0.708 rs6908688 chr6:27886051 A/G cg08851530 chr6:28072375 NA 0.78 8.04 0.3 4.51e-15 Parkinson's disease; BRCA cis rs9462027 0.628 rs2764208 chr6:34714322 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.06 -0.3 3.75e-15 Systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.22e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.99 0.33 2.85e-18 Motion sickness; BRCA cis rs62229266 0.804 rs12483151 chr21:37419578 C/T cg12218747 chr21:37451666 NA -0.33 -7.92 -0.3 1.08e-14 Mitral valve prolapse; BRCA cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.87 -0.33 7.03e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg02659138 chr7:134003124 SLC35B4 -0.36 -10.11 -0.37 2.11e-22 Mean platelet volume; BRCA cis rs7904985 1.000 rs10887586 chr10:88113521 G/A cg07322936 chr10:88137208 NA -0.42 -8.41 -0.32 2.78e-16 Barrett's esophagus; BRCA cis rs1997103 1.000 rs9649851 chr7:55398692 C/A cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4653767 1.000 rs10916030 chr1:226919908 C/T cg05049329 chr1:226924846 ITPKB 0.34 9.59 0.35 1.92e-20 Parkinson's disease; BRCA cis rs1577917 1.000 rs13196930 chr6:86652245 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -8.83 -0.33 1.04e-17 Response to antipsychotic treatment; BRCA cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.57 -0.42 3.03e-28 Bipolar disorder; BRCA cis rs2191566 1.000 rs7256908 chr19:44528898 C/T cg20607764 chr19:44506953 ZNF230 -0.37 -7.88 -0.3 1.46e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs2882667 0.858 rs13177503 chr5:138432759 G/C cg04439458 chr5:138467593 SIL1 -0.41 -10.29 -0.38 4.29e-23 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs1005277 0.505 rs10827835 chr10:38150709 G/A cg17830980 chr10:43048298 ZNF37B 0.42 9.91 0.36 1.26e-21 Extrinsic epigenetic age acceleration; BRCA cis rs922182 0.617 rs55694045 chr15:64245943 T/C cg24729988 chr15:64271149 DAPK2 0.49 10.36 0.38 2.46e-23 Blood protein levels; BRCA cis rs8062405 0.723 rs762633 chr16:28608341 T/C cg16576597 chr16:28551801 NUPR1 0.34 9.04 0.34 1.92e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs7647973 0.710 rs1532204 chr3:49609477 C/G cg21659725 chr3:3221576 CRBN -0.49 -8.5 -0.32 1.31e-16 Menarche (age at onset); BRCA cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg04455712 chr21:45112962 RRP1B 0.41 10.88 0.4 2.11e-25 Mean corpuscular volume; BRCA cis rs17270561 0.636 rs9379779 chr6:25695441 G/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.52 0.32 1.13e-16 Iron status biomarkers; BRCA cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.35 7.91 0.3 1.12e-14 Coronary artery disease; BRCA cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg01689657 chr7:91764605 CYP51A1 -0.22 -8.18 -0.31 1.51e-15 Breast cancer; BRCA cis rs2304069 0.913 rs7734382 chr5:149383241 A/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.5 8.34 0.31 4.7e-16 HIV-1 control; BRCA cis rs7737355 1.000 rs798416 chr5:130693100 T/C cg06307176 chr5:131281290 NA -0.47 -9.11 -0.34 1.01e-18 Life satisfaction; BRCA cis rs9517313 0.615 rs4772079 chr13:99090837 C/G cg20487152 chr13:99095054 FARP1 -0.42 -11.5 -0.41 5.89e-28 Neuroticism; BRCA cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg23711669 chr6:146136114 FBXO30 0.8 18.97 0.6 5.73e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.08 0.34 1.34e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg08999081 chr20:33150536 PIGU 0.35 9.07 0.34 1.4e-18 Coronary artery disease; BRCA cis rs2070488 0.965 rs2366123 chr3:38493153 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.69 0.63 3.71e-73 Electrocardiographic conduction measures; BRCA cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg09462578 chr12:12878428 APOLD1 -0.58 -10.46 -0.38 9.69e-24 Systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg05340658 chr4:99064831 C4orf37 -0.69 -17.23 -0.56 6.39e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs71636778 0.543 rs34409791 chr1:27245363 A/G cg12203394 chr1:27248618 NUDC 0.6 9.42 0.35 7.92e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs12950390 0.853 rs11079790 chr17:45853626 G/A cg03474202 chr17:45855739 NA -0.46 -12.5 -0.44 3.21e-32 IgG glycosylation; BRCA cis rs514406 0.505 rs387436 chr1:53179376 C/T cg16325326 chr1:53192061 ZYG11B -0.9 -25.01 -0.7 9.36e-97 Monocyte count; BRCA cis rs2760061 0.598 rs605410 chr1:228116281 A/G cg02753203 chr1:228287806 NA -0.57 -12.12 -0.43 1.46e-30 Diastolic blood pressure; BRCA cis rs514406 0.729 rs534070 chr1:53308858 T/G cg25767906 chr1:53392781 SCP2 -0.46 -10.3 -0.38 4.13e-23 Monocyte count; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg15112475 chr7:1198522 ZFAND2A -0.37 -8.68 -0.32 3.25e-17 Longevity;Endometriosis; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg16145915 chr7:1198662 ZFAND2A -0.68 -18.5 -0.59 1.63e-61 Longevity;Endometriosis; BRCA cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg05707623 chr12:122985044 ZCCHC8 -0.44 -9.02 -0.34 2.16e-18 Body mass index; BRCA cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg24675658 chr1:53192096 ZYG11B -0.52 -11.55 -0.42 3.57e-28 Monocyte count; BRCA cis rs9400271 0.632 rs9374072 chr6:109591586 A/G cg01475377 chr6:109611718 NA -0.44 -10.4 -0.38 1.7e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs295140 0.506 rs4673855 chr2:201136143 A/G cg23649088 chr2:200775458 C2orf69 -0.39 -8.25 -0.31 9.08e-16 QT interval; BRCA cis rs9309473 1.000 rs13421462 chr2:73719875 A/C cg20560298 chr2:73613845 ALMS1 -0.46 -11.34 -0.41 2.66e-27 Metabolite levels; BRCA cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg20887711 chr4:1340912 KIAA1530 0.66 14.34 0.49 1.28e-40 Longevity; BRCA cis rs34779708 0.931 rs17582416 chr10:35287650 A/C cg03585969 chr10:35415529 CREM 0.47 9.69 0.36 7.98e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs875971 0.798 rs12698522 chr7:65967341 T/C cg18876405 chr7:65276391 NA 0.5 11.1 0.4 2.63e-26 Aortic root size; BRCA cis rs3772130 1.000 rs7427165 chr3:121364624 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.53 9.44 0.35 6.61e-20 Cognitive performance; BRCA cis rs1499972 0.878 rs817513 chr3:117733823 A/T cg07612923 chr3:117604196 NA -0.6 -7.85 -0.3 1.79e-14 Schizophrenia; BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg04944784 chr2:26401820 FAM59B -0.69 -11.47 -0.41 8.14e-28 Gut microbiome composition (summer); BRCA cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg05623727 chr3:50126028 RBM5 -0.42 -9.82 -0.36 2.79e-21 Intelligence (multi-trait analysis); BRCA cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg06697600 chr4:7070879 GRPEL1 -0.62 -12.55 -0.44 1.97e-32 Monocyte percentage of white cells; BRCA trans rs10805346 0.505 rs35995899 chr4:10112862 T/C cg26043149 chr18:55253948 FECH 0.46 10.63 0.39 2.06e-24 Urate levels in overweight individuals;Urate levels in obese individuals; BRCA cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg00071950 chr4:10020882 SLC2A9 -0.51 -11.85 -0.42 2.11e-29 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7824557 0.806 rs6601573 chr8:11094751 A/G cg15556689 chr8:8085844 FLJ10661 -0.35 -8.53 -0.32 1.05e-16 Retinal vascular caliber; BRCA trans rs8073060 0.963 rs35614987 chr17:33869466 A/C cg19694781 chr19:47549865 TMEM160 0.57 12.24 0.44 4.24e-31 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9290065 0.519 rs6441346 chr3:160709229 C/T cg03342759 chr3:160939853 NMD3 -0.5 -10.16 -0.37 1.36e-22 Kawasaki disease; BRCA trans rs6600671 1.000 rs2185281 chr1:121179991 A/G cg17023122 chr1:144479586 NA 0.33 7.9 0.3 1.22e-14 Hip geometry; BRCA cis rs4713675 0.565 rs4713674 chr6:33708169 C/T cg14003231 chr6:33640908 ITPR3 -0.34 -8.18 -0.31 1.54e-15 Plateletcrit; BRCA cis rs1005277 1.000 rs1005277 chr10:38218259 A/C cg00409905 chr10:38381863 ZNF37A 0.47 8.52 0.32 1.16e-16 Extrinsic epigenetic age acceleration; BRCA cis rs250677 0.687 rs3095947 chr5:148436728 T/C cg18129178 chr5:148520854 ABLIM3 -0.6 -12.3 -0.44 2.32e-31 Breast cancer; BRCA cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.66 -0.5 3.76e-42 Chronic sinus infection; BRCA cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg18225595 chr11:63971243 STIP1 0.52 9.44 0.35 6.78e-20 Mean platelet volume; BRCA cis rs7520050 0.966 rs1768803 chr1:46546208 T/C cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.33e-19 Red blood cell count;Reticulocyte count; BRCA cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg08999081 chr20:33150536 PIGU 0.38 9.66 0.36 1.05e-20 Coronary artery disease; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18765753 chr7:1198926 ZFAND2A -0.5 -12.78 -0.45 1.73e-33 Longevity;Endometriosis; BRCA trans rs61931739 0.500 rs10844829 chr12:34304916 G/T cg26384229 chr12:38710491 ALG10B 0.67 14.19 0.49 6.23e-40 Morning vs. evening chronotype; BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.87 0.48 2.04e-38 Alzheimer's disease; BRCA cis rs875622 0.556 rs4808047 chr19:16527834 T/C cg10248733 chr19:16607483 C19orf44;CALR3 -0.55 -9.97 -0.37 7.22e-22 White matter integrity;Neutrophil percentage of white cells; BRCA cis rs853679 0.517 rs2273564 chr6:28057594 A/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.17e-15 Depression; BRCA cis rs12477438 0.520 rs7604557 chr2:99747829 A/G cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.46e-23 Chronic sinus infection; BRCA cis rs1372520 0.577 rs2737028 chr4:90717016 A/G cg15133208 chr4:90757351 SNCA -0.39 -7.85 -0.3 1.74e-14 Neuroticism; BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg22920501 chr2:26401640 FAM59B -0.65 -11.31 -0.41 3.64e-27 Gut microbiome composition (summer); BRCA trans rs11992162 0.591 rs35657308 chr8:11804402 G/A cg15556689 chr8:8085844 FLJ10661 -0.32 -8.47 -0.32 1.68e-16 Monocyte count; BRCA trans rs1005277 0.522 rs9417256 chr10:37976990 A/G cg23533926 chr12:111358616 MYL2 -0.39 -8.13 -0.31 2.29e-15 Extrinsic epigenetic age acceleration; BRCA cis rs1506636 1.000 rs12333705 chr7:123356062 C/T cg03229431 chr7:123269106 ASB15 -0.61 -13.96 -0.48 7.91e-39 Plateletcrit;Platelet count; BRCA cis rs6942756 0.688 rs2718089 chr7:128927022 G/T cg02491457 chr7:128862824 NA 0.56 11.72 0.42 7.37e-29 White matter hyperintensity burden; BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.37 8.11 0.31 2.51e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9942416 0.660 rs166183 chr5:74977845 T/C cg19683494 chr5:74908142 NA -0.48 -8.93 -0.33 4.6e-18 Age-related disease endophenotypes; BRCA cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.63 -0.39 2.1e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg22974920 chr21:40686053 BRWD1 -0.4 -8.81 -0.33 1.21e-17 Cognitive function; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg08807101 chr21:30365312 RNF160 -0.38 -8.17 -0.31 1.61e-15 Pancreatic cancer; BRCA trans rs7824557 0.767 rs17797443 chr8:11164012 T/C cg06636001 chr8:8085503 FLJ10661 0.53 9.98 0.37 6.64e-22 Retinal vascular caliber; BRCA cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg08514558 chr10:81106712 PPIF 0.38 8.42 0.32 2.46e-16 Height; BRCA cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11890956 chr21:40555474 PSMG1 0.67 15.51 0.52 2.7e-46 Cognitive function; BRCA cis rs11098499 0.913 rs56122576 chr4:120129336 A/G cg09307838 chr4:120376055 NA 0.6 11.05 0.4 4.23e-26 Corneal astigmatism; BRCA cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg16586182 chr3:47516702 SCAP 0.39 8.2 0.31 1.31e-15 Birth weight; BRCA cis rs7395581 0.918 rs10838692 chr11:47345100 T/C cg25783544 chr11:47291846 MADD 0.43 9.58 0.35 2.09e-20 HDL cholesterol; BRCA cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg11890956 chr21:40555474 PSMG1 -0.6 -13.57 -0.47 4.64e-37 Menarche (age at onset); BRCA trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg26384229 chr12:38710491 ALG10B 0.58 13.3 0.47 8.01e-36 Morning vs. evening chronotype; BRCA cis rs9814567 0.928 rs6768323 chr3:134268737 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4713118 0.662 rs9393881 chr6:28023751 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.47 0.32 1.66e-16 Parkinson's disease; BRCA cis rs11105298 0.891 rs11105325 chr12:89938590 G/A cg00757033 chr12:89920650 WDR51B 0.54 10.78 0.39 5.25e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg11366901 chr6:160182831 ACAT2 0.7 13.05 0.46 1.09e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs17376456 0.569 rs2045021 chr5:93224222 G/A cg25358565 chr5:93447407 FAM172A -0.68 -11.63 -0.42 1.67e-28 Diabetic retinopathy; BRCA cis rs1005277 0.579 rs2472175 chr10:38382901 T/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.92 -0.56 2.46e-53 Extrinsic epigenetic age acceleration; BRCA cis rs1403694 0.655 rs3806688 chr3:186434819 T/C cg12454167 chr3:186435060 KNG1 0.29 7.9 0.3 1.22e-14 Blood protein levels; BRCA trans rs12310956 0.532 rs10844720 chr12:33987859 G/T cg26384229 chr12:38710491 ALG10B 0.51 11.03 0.4 4.98e-26 Morning vs. evening chronotype; BRCA cis rs11608355 0.545 rs2302703 chr12:109898832 G/A cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs11229555 0.645 rs11229463 chr11:58210147 A/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.86 -0.33 7.77e-18 Alzheimer's disease (late onset); BRCA cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg03676636 chr4:99064102 C4orf37 0.23 8.2 0.31 1.31e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7520050 1.000 rs785511 chr1:46534498 T/C cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.41e-19 Red blood cell count;Reticulocyte count; BRCA cis rs9473147 0.516 rs7749167 chr6:47493940 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.93e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.43 -9.48 -0.35 4.92e-20 Alzheimer's disease (late onset); BRCA cis rs17253792 0.822 rs77415412 chr14:56154146 A/G cg01858014 chr14:56050164 KTN1 -0.76 -9.53 -0.35 3.34e-20 Putamen volume; BRCA cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg09184832 chr6:79620586 NA -0.52 -11.41 -0.41 1.44e-27 Intelligence (multi-trait analysis); BRCA cis rs9682041 0.740 rs6444929 chr3:170150076 C/T cg11886554 chr3:170076028 SKIL 0.78 12.65 0.45 6.7e-33 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs9814567 1.000 rs13322305 chr3:134310791 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7904368 0.951 rs7074647 chr10:16855455 T/C cg14835575 chr10:16859367 RSU1 0.51 11.52 0.41 4.89e-28 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs11764590 0.671 rs62444906 chr7:2083161 G/T cg23422044 chr7:1970798 MAD1L1 -0.56 -9.32 -0.35 1.85e-19 Neuroticism; BRCA cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs4308124 0.708 rs6727313 chr2:111971540 G/A cg04571233 chr2:111982156 NA -0.45 -9.62 -0.36 1.52e-20 Vitiligo; BRCA cis rs11252926 0.545 rs11252693 chr10:532139 A/G cg03684893 chr10:554711 DIP2C -0.43 -10.37 -0.38 2.1e-23 Psychosis in Alzheimer's disease; BRCA cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg12310025 chr6:25882481 NA -0.57 -13.9 -0.48 1.51e-38 Blood metabolite levels; BRCA cis rs11969893 0.737 rs6930051 chr6:101406108 A/G cg12253828 chr6:101329408 ASCC3 0.98 13.88 0.48 1.78e-38 Economic and political preferences (immigration/crime); BRCA cis rs117623576 0.618 rs211413 chr10:32396902 C/A cg03047570 chr10:32398778 NA 0.57 8.82 0.33 1.1e-17 Anti-saccade response; BRCA cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA trans rs75804782 0.630 rs56354063 chr2:239253919 A/G cg01134436 chr17:81009848 B3GNTL1 0.78 8.13 0.31 2.21e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs7647973 0.626 rs4855882 chr3:49715354 G/T cg03060546 chr3:49711283 APEH 0.56 8.77 0.33 1.65e-17 Menarche (age at onset); BRCA cis rs1568889 0.667 rs16917914 chr11:28459909 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.5 9.6 0.35 1.83e-20 Bipolar disorder; BRCA cis rs16867335 0.625 rs7573877 chr2:181478111 A/G cg23363182 chr2:181467187 NA -0.43 -9.26 -0.34 3e-19 Survival in rectal cancer; BRCA cis rs17641971 0.684 rs12545097 chr8:49951977 A/G cg00325661 chr8:49890786 NA 0.37 10.29 0.38 4.37e-23 Blood metabolite levels; BRCA cis rs11098499 0.780 rs10013652 chr4:120292256 A/G cg09307838 chr4:120376055 NA 0.66 14.35 0.49 1.09e-40 Corneal astigmatism; BRCA cis rs116095464 0.558 rs56298907 chr5:283280 C/A cg22857025 chr5:266934 NA -1.04 -19.68 -0.61 9.4e-68 Breast cancer; BRCA cis rs2731664 0.756 rs2545796 chr5:176864269 T/C cg23176889 chr5:176863531 GRK6 -0.6 -16.02 -0.54 8.41e-49 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.932 rs3940842 chr5:93534858 C/A cg21475434 chr5:93447410 FAM172A 0.73 9.25 0.34 3.42e-19 Diabetic retinopathy; BRCA cis rs72615157 0.628 rs7801070 chr7:99847147 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.58 9.9 0.36 1.32e-21 Lung function (FEV1/FVC); BRCA cis rs9815354 0.767 rs73071238 chr3:41992243 A/G cg03022575 chr3:42003672 ULK4 0.73 10.02 0.37 4.78e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg11752832 chr7:134001865 SLC35B4 0.5 12.74 0.45 2.81e-33 Mean platelet volume; BRCA cis rs921968 0.509 rs655441 chr2:219357545 C/T cg02176678 chr2:219576539 TTLL4 0.45 11.62 0.42 1.97e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.84 18.23 0.59 4e-60 IgG glycosylation; BRCA cis rs58785573 0.624 rs337605 chr4:38647753 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.48 10.22 0.37 7.88e-23 Lymphocyte percentage of white cells; BRCA cis rs700651 0.789 rs892514 chr2:198905270 T/C cg00792783 chr2:198669748 PLCL1 0.37 8.2 0.31 1.32e-15 Intracranial aneurysm; BRCA cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg06022373 chr22:39101656 GTPBP1 0.73 18.11 0.58 1.89e-59 Menopause (age at onset); BRCA cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg18132916 chr6:79620363 NA -0.46 -10.63 -0.39 2e-24 Intelligence (multi-trait analysis); BRCA cis rs644799 0.601 rs662168 chr11:95586982 C/T cg03916912 chr11:95522834 CEP57;FAM76B 0.55 12.72 0.45 3.46e-33 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg04455712 chr21:45112962 RRP1B 0.39 10.41 0.38 1.5e-23 Mean corpuscular volume; BRCA cis rs1953600 0.870 rs2788296 chr10:81937889 G/A cg04850286 chr10:81895943 PLAC9 0.31 8.8 0.33 1.27e-17 Sarcoidosis; BRCA cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg08999081 chr20:33150536 PIGU -0.46 -12.8 -0.45 1.48e-33 Glomerular filtration rate (creatinine); BRCA cis rs2806561 1.000 rs1571466 chr1:23449183 T/C cg19743168 chr1:23544995 NA 0.4 9.66 0.36 1.03e-20 Height; BRCA cis rs17270561 0.609 rs7772382 chr6:25708116 C/T cg16482183 chr6:26056742 HIST1H1C 0.43 8.4 0.32 2.86e-16 Iron status biomarkers; BRCA cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg05283184 chr6:79620031 NA -0.43 -11.1 -0.4 2.69e-26 Intelligence (multi-trait analysis); BRCA cis rs7833986 1.000 rs13281873 chr8:57101799 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.45 8.14 0.31 2.13e-15 Height; BRCA cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg09184832 chr6:79620586 NA -0.48 -10.5 -0.38 6.52e-24 Intelligence (multi-trait analysis); BRCA cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg01416388 chr22:39784598 NA 0.42 8.15 0.31 1.9e-15 Intelligence (multi-trait analysis); BRCA cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg08999081 chr20:33150536 PIGU 0.36 9.13 0.34 8.7e-19 Coronary artery disease; BRCA cis rs10782582 0.609 rs56159153 chr1:76353498 T/G cg03433033 chr1:76189801 ACADM -0.4 -8.17 -0.31 1.65e-15 Daytime sleep phenotypes; BRCA cis rs3092073 0.624 rs34293711 chr20:44587186 C/T cg17986701 chr20:44574422 PCIF1 0.36 8.84 0.33 9.3e-18 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.932 rs4678604 chr3:38444273 G/A cg24069376 chr3:38537580 EXOG 0.4 11.37 0.41 2.13e-27 Electrocardiographic conduction measures; BRCA cis rs6714710 0.603 rs12104810 chr2:98443658 C/T cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.79e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg27286337 chr10:134555280 INPP5A 0.64 11.36 0.41 2.38e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs35847492 1.000 rs35847492 chr8:9276025 G/C cg06636001 chr8:8085503 FLJ10661 0.49 9.45 0.35 6.52e-20 Neuroticism; BRCA cis rs4908760 0.827 rs7513420 chr1:8681044 T/C cg20416874 chr1:8611966 RERE -0.28 -8.1 -0.31 2.74e-15 Vitiligo; BRCA cis rs7568458 0.591 rs55971080 chr2:85812746 T/C cg02493740 chr2:85810744 VAMP5 -0.39 -8.28 -0.31 7.38e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg21770322 chr7:97807741 LMTK2 0.48 11.97 0.43 6.17e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs6430585 0.528 rs895285 chr2:136710554 A/G cg07169764 chr2:136633963 MCM6 1.22 23.71 0.68 1.27e-89 Corneal structure; BRCA cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg01181863 chr3:195395398 SDHAP2 -0.58 -10.61 -0.39 2.47e-24 Pancreatic cancer; BRCA trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg15556689 chr8:8085844 FLJ10661 -0.37 -10.14 -0.37 1.6e-22 Neuroticism; BRCA cis rs4664304 0.966 rs925407 chr2:160767502 A/C cg01092293 chr2:160761427 LY75 -0.44 -10.49 -0.38 7.12e-24 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg06115741 chr20:33292138 TP53INP2 0.4 8.94 0.33 4.12e-18 Coronary artery disease; BRCA cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg08085267 chr17:45401833 C17orf57 -0.6 -12.38 -0.44 1.1e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7927771 1.000 rs11605774 chr11:47832793 G/A cg18512352 chr11:47633146 NA -0.35 -8.48 -0.32 1.56e-16 Subjective well-being; BRCA cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg13073564 chr4:8508604 NA 0.42 11.44 0.41 1.08e-27 Response to antineoplastic agents; BRCA cis rs7264396 0.673 rs2425163 chr20:34432670 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.93 0.3 9.51e-15 Total cholesterol levels; BRCA cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg16262614 chr3:133464971 TF 0.24 7.91 0.3 1.13e-14 Iron status biomarkers (transferrin levels); BRCA cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.41 0.5 5.76e-41 Colorectal cancer; BRCA cis rs3892630 0.588 rs7248798 chr19:33303684 G/T cg22980127 chr19:33182716 NUDT19 0.91 20.72 0.63 2.29e-73 Red blood cell traits; BRCA cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg12310025 chr6:25882481 NA -0.56 -12.31 -0.44 2.2e-31 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg23791538 chr6:167370224 RNASET2 -0.36 -8.51 -0.32 1.28e-16 Crohn's disease; BRCA cis rs10744422 1.000 rs7138398 chr12:123341833 G/C cg25930673 chr12:123319894 HIP1R -0.53 -8.14 -0.31 2.06e-15 Schizophrenia; BRCA trans rs116095464 0.558 rs9687621 chr5:229194 C/T cg00938859 chr5:1591904 SDHAP3 0.64 8.89 0.33 6.41e-18 Breast cancer; BRCA cis rs7481584 0.624 rs451060 chr11:3056389 G/A cg08508325 chr11:3079039 CARS 0.28 8.58 0.32 7.38e-17 Calcium levels; BRCA cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06022373 chr22:39101656 GTPBP1 -0.67 -17.12 -0.56 2.3e-54 Menopause (age at onset); BRCA cis rs17401966 0.931 rs12131441 chr1:10428952 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.27 -0.31 7.87e-16 Hepatocellular carcinoma; BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg00106254 chr7:1943704 MAD1L1 -0.41 -10.15 -0.37 1.47e-22 Bipolar disorder and schizophrenia; BRCA cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg11764359 chr7:65958608 NA -0.67 -14.91 -0.51 2.34e-43 Aortic root size; BRCA cis rs7493 0.755 rs62467350 chr7:94970114 T/C cg17330251 chr7:94953956 PON1 -0.4 -8.46 -0.32 1.84e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs11690935 0.550 rs6746701 chr2:172869255 G/A cg13550731 chr2:172543902 DYNC1I2 0.49 12.1 0.43 1.76e-30 Schizophrenia; BRCA trans rs6582630 0.555 rs7969922 chr12:38529491 C/T cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.19e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs62158211 1.000 rs4618068 chr2:114109355 C/T cg17784749 chr2:114082611 LOC440839 0.48 8.41 0.32 2.75e-16 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; BRCA cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg22974920 chr21:40686053 BRWD1 -0.4 -8.91 -0.33 5.17e-18 Cognitive function; BRCA cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg06552810 chr11:31128660 NA 0.4 8.89 0.33 6.19e-18 Red blood cell count; BRCA cis rs950776 0.518 rs8053 chr15:78841220 T/C cg22563815 chr15:78856949 CHRNA5 -0.35 -8.41 -0.32 2.65e-16 Sudden cardiac arrest; BRCA cis rs7737355 1.000 rs7719126 chr5:130613749 T/C cg06307176 chr5:131281290 NA 0.47 9.08 0.34 1.36e-18 Life satisfaction; BRCA cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg12698349 chr2:225449008 CUL3 0.62 13.54 0.47 6.86e-37 IgE levels in asthmatics (D.p. specific); BRCA cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg06115741 chr20:33292138 TP53INP2 0.39 8.62 0.32 5.23e-17 Glomerular filtration rate (creatinine); BRCA cis rs4481887 0.927 rs6689193 chr1:248482900 T/A cg00666640 chr1:248458726 OR2T12 0.32 8.95 0.33 3.99e-18 Common traits (Other); BRCA cis rs2832191 0.740 rs6516890 chr21:30476812 T/A cg08807101 chr21:30365312 RNF160 0.59 15.15 0.51 1.55e-44 Dental caries; BRCA cis rs7903847 0.596 rs10786340 chr10:99156563 G/C cg08345082 chr10:99160200 RRP12 -0.3 -8.83 -0.33 9.93e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg20607798 chr8:58055168 NA 0.48 8.39 0.31 3.13e-16 Developmental language disorder (linguistic errors); BRCA cis rs4803468 1.000 rs55986560 chr19:41939835 C/T cg09537434 chr19:41945824 ATP5SL 1.03 25.42 0.71 4.7e-99 Height; BRCA cis rs11711311 0.668 rs11718061 chr3:113341826 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.41 8.77 0.33 1.66e-17 IgG glycosylation; BRCA cis rs1506636 0.924 rs2402668 chr7:123296605 T/A cg03229431 chr7:123269106 ASB15 -0.64 -14.3 -0.49 1.95e-40 Plateletcrit;Platelet count; BRCA cis rs367943 0.723 rs1965429 chr5:112679373 G/T cg12552261 chr5:112820674 MCC -0.4 -8.72 -0.33 2.33e-17 Type 2 diabetes; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg25036284 chr2:26402008 FAM59B 0.77 10.67 0.39 1.41e-24 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.82e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg08219700 chr8:58056026 NA 0.45 8.1 0.31 2.86e-15 Developmental language disorder (linguistic errors); BRCA cis rs1577917 0.740 rs2758843 chr6:86328431 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.82 -0.33 1.09e-17 Response to antipsychotic treatment; BRCA cis rs6910061 0.830 rs41270602 chr6:11094690 G/T cg27233058 chr6:11094804 LOC221710 0.49 8.32 0.31 5.48e-16 Diabetic kidney disease; BRCA cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg05623727 chr3:50126028 RBM5 0.49 11.61 0.42 2.07e-28 Body mass index; BRCA cis rs1043763 0.826 rs10847689 chr12:122613000 A/G cg14400030 chr12:122498111 BCL7A -0.6 -13.65 -0.48 2.04e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg15839431 chr19:19639596 YJEFN3 -0.43 -8.67 -0.32 3.64e-17 Bipolar disorder; BRCA cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg20790798 chr5:1857306 NA -0.38 -8.78 -0.33 1.55e-17 Cardiovascular disease risk factors; BRCA cis rs17376456 1.000 rs13154249 chr5:93550508 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.49 0.32 1.43e-16 Diabetic retinopathy; BRCA cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg11663144 chr21:46675770 NA -0.61 -13.91 -0.48 1.22e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11758351 0.518 rs79922979 chr6:26224975 A/G cg01420254 chr6:26195488 NA 0.55 8.64 0.32 4.59e-17 Gout;Renal underexcretion gout; BRCA trans rs9325144 0.555 rs7955128 chr12:38684121 A/T cg23762105 chr12:34175262 ALG10 -0.34 -8.45 -0.32 1.96e-16 Morning vs. evening chronotype; BRCA cis rs701145 0.585 rs1713854 chr3:153848030 T/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs10751667 0.666 rs7395182 chr11:927553 A/C ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs12760731 0.641 rs12691479 chr1:178328754 G/A cg00404053 chr1:178313656 RASAL2 0.62 8.66 0.32 3.96e-17 Obesity-related traits; BRCA cis rs6878727 0.850 rs7712066 chr5:123717754 A/G cg01806427 chr5:123737813 NA 0.38 8.79 0.33 1.42e-17 Breast cancer; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg13397359 chr6:42928475 GNMT -0.51 -12.2 -0.43 6.31e-31 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg22105103 chr4:187893119 NA 0.3 9.61 0.36 1.61e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg01579765 chr21:45077557 HSF2BP -0.4 -10.59 -0.39 2.84e-24 Mean corpuscular volume; BRCA trans rs6582630 0.519 rs8186881 chr12:38310285 A/G cg06521331 chr12:34319734 NA -0.47 -8.72 -0.33 2.46e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11890956 chr21:40555474 PSMG1 1.06 30.43 0.77 2.04e-126 Cognitive function; BRCA cis rs939658 0.776 rs68147688 chr15:79443848 G/A cg17916960 chr15:79447300 NA -0.46 -11.45 -0.41 9.24e-28 Refractive error; BRCA cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.33e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10463316 0.894 rs3905511 chr5:150768204 G/A cg03212797 chr5:150827313 SLC36A1 -0.43 -8.33 -0.31 4.91e-16 Metabolite levels (Pyroglutamine); BRCA cis rs73416724 1.000 rs17209407 chr6:43358362 A/G cg26312998 chr6:43337775 ZNF318 0.49 7.97 0.3 7.26e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs79839061 0.610 rs34006051 chr4:847445 C/T cg23992470 chr4:843637 GAK 0.56 8.43 0.32 2.31e-16 Intelligence (multi-trait analysis); BRCA cis rs6815814 0.851 rs73236644 chr4:38863193 A/G cg02016764 chr4:38805732 TLR1 -0.53 -8.34 -0.31 4.67e-16 Breast cancer; BRCA cis rs9868809 0.505 rs13434258 chr3:48738491 T/C cg01304814 chr3:48885189 PRKAR2A 0.57 7.96 0.3 7.88e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2797160 0.935 rs6940748 chr6:125994080 C/T cg05901451 chr6:126070800 HEY2 -0.41 -10.08 -0.37 2.73e-22 Endometrial cancer; BRCA cis rs60871478 1.000 rs34260834 chr7:822958 A/G cg27478167 chr7:817139 HEATR2 -0.44 -9.52 -0.35 3.55e-20 Cerebrospinal P-tau181p levels; BRCA cis rs113835537 0.529 rs3816492 chr11:66297363 C/T cg24851651 chr11:66362959 CCS 0.52 8.98 0.33 2.9e-18 Airway imaging phenotypes; BRCA cis rs757110 0.705 rs10832778 chr11:17394073 C/G cg04705435 chr11:17411270 KCNJ11 0.44 9.37 0.35 1.23e-19 Type 2 diabetes; BRCA cis rs3820928 0.605 rs4281898 chr2:227855493 A/C cg05526886 chr2:227700861 RHBDD1 -0.38 -7.86 -0.3 1.62e-14 Pulmonary function; BRCA cis rs2153535 0.584 rs62395678 chr6:8371689 C/T cg21535247 chr6:8435926 SLC35B3 -0.37 -8.37 -0.31 3.54e-16 Motion sickness; BRCA cis rs514406 0.505 rs447581 chr1:53177098 T/C cg08859206 chr1:53392774 SCP2 -0.39 -8.25 -0.31 9.33e-16 Monocyte count; BRCA cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg26031613 chr14:104095156 KLC1 0.73 15.91 0.53 2.85e-48 Body mass index; BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.19 -0.31 1.39e-15 Total body bone mineral density; BRCA cis rs2153535 0.542 rs9505465 chr6:8510846 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.63 0.39 2.14e-24 Motion sickness; BRCA cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg14289826 chr9:140003911 NA -0.49 -12.77 -0.45 2e-33 Cerebrospinal fluid biomarker levels; BRCA cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg05340658 chr4:99064831 C4orf37 0.67 16.82 0.55 8.11e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs6582630 0.519 rs12366667 chr12:38332632 C/T cg06521331 chr12:34319734 NA -0.48 -8.79 -0.33 1.39e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2243480 1.000 rs13310597 chr7:65598540 A/G cg18252515 chr7:66147081 NA -1.07 -15.7 -0.53 3.09e-47 Diabetic kidney disease; BRCA cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg06784218 chr1:46089804 CCDC17 -0.52 -12.5 -0.44 3.03e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg11707556 chr5:10655725 ANKRD33B 0.33 8.02 0.3 5.04e-15 Height; BRCA cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg27398817 chr8:82754497 SNX16 -0.45 -8.94 -0.33 4.02e-18 Diastolic blood pressure; BRCA cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg00339695 chr16:24857497 SLC5A11 0.34 7.92 0.3 1.03e-14 Intelligence (multi-trait analysis); BRCA cis rs7572733 0.555 rs2341778 chr2:198776546 G/A cg00792783 chr2:198669748 PLCL1 -0.48 -10.32 -0.38 3.35e-23 Dermatomyositis; BRCA trans rs561341 1.000 rs530715 chr17:30320544 T/G cg20587970 chr11:113659929 NA -0.96 -18.65 -0.59 2.81e-62 Hip circumference adjusted for BMI; BRCA cis rs6426558 0.537 rs7523167 chr1:227365304 G/A cg10327440 chr1:227177885 CDC42BPA -0.47 -9.32 -0.35 1.9e-19 Neutrophil percentage of white cells; BRCA cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg03425785 chr20:62221387 GMEB2 0.52 8.32 0.31 5.51e-16 Glioblastoma; BRCA cis rs1499614 1.000 rs2707838 chr7:66159201 C/T cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs7727544 0.684 rs272893 chr5:131663062 T/C cg07395648 chr5:131743802 NA -0.39 -9.66 -0.36 1.08e-20 Blood metabolite levels; BRCA cis rs11945232 1.000 rs28630962 chr4:88336386 C/T cg23841344 chr4:88312519 HSD17B11 -0.5 -9.73 -0.36 6.04e-21 Intelligence (multi-trait analysis); BRCA cis rs4285028 0.699 rs2689285 chr3:121586486 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.7 13.06 0.46 1.05e-34 Multiple sclerosis; BRCA cis rs490234 0.841 rs476819 chr9:128362737 C/T cg14078157 chr9:128172775 NA -0.33 -7.86 -0.3 1.66e-14 Mean arterial pressure; BRCA cis rs2204008 0.837 rs73112346 chr12:38357606 C/T cg26384229 chr12:38710491 ALG10B 0.77 17.45 0.57 4.59e-56 Bladder cancer; BRCA cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.35e-15 Extrinsic epigenetic age acceleration; BRCA trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg26384229 chr12:38710491 ALG10B -0.75 -16.09 -0.54 3.89e-49 Morning vs. evening chronotype; BRCA cis rs524281 0.647 rs2302883 chr11:65824994 T/C cg16950941 chr11:66035639 RAB1B -0.41 -8.88 -0.33 6.83e-18 Electroencephalogram traits; BRCA cis rs11711311 1.000 rs12636577 chr3:113497507 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.8 -0.36 3.31e-21 IgG glycosylation; BRCA trans rs9951602 0.512 rs9949512 chr18:76641845 T/C cg02800362 chr5:177631904 HNRNPAB 0.76 17.58 0.57 1.01e-56 Obesity-related traits; BRCA cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.19 0.34 5.32e-19 Height; BRCA cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg18196295 chr10:418757 DIP2C -0.49 -11.07 -0.4 3.45e-26 Psychosis in Alzheimer's disease; BRCA cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg02659138 chr7:134003124 SLC35B4 0.32 9.78 0.36 3.74e-21 Mean platelet volume; BRCA cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg04455712 chr21:45112962 RRP1B 0.46 12.35 0.44 1.44e-31 Mean corpuscular volume; BRCA cis rs7727544 0.582 rs4361509 chr5:131536753 A/G cg14196790 chr5:131705035 SLC22A5 -0.37 -9.27 -0.34 2.87e-19 Blood metabolite levels; BRCA cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.11e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7520050 0.751 rs2230657 chr1:46073489 G/A cg24296786 chr1:45957014 TESK2 0.46 10.37 0.38 2.17e-23 Red blood cell count;Reticulocyte count; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.01 0.58 5.88e-59 Alzheimer's disease; BRCA cis rs2204008 0.743 rs2127952 chr12:37995364 G/T cg13010199 chr12:38710504 ALG10B 0.41 8.36 0.31 3.97e-16 Bladder cancer; BRCA cis rs7264396 0.790 rs6121018 chr20:34249060 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -16.25 -0.54 5.74e-50 Total cholesterol levels; BRCA cis rs17376456 0.877 rs10035340 chr5:93490465 C/T cg21475434 chr5:93447410 FAM172A 0.72 8.89 0.33 6e-18 Diabetic retinopathy; BRCA cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg24399712 chr22:39784796 NA 0.58 12.51 0.44 2.82e-32 Intelligence (multi-trait analysis); BRCA cis rs6450176 1.000 rs7736354 chr5:53297591 C/T ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.18 -0.51 1.2e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs4787491 0.765 rs8054507 chr16:30046042 G/A cg06326092 chr16:30034487 C16orf92 0.38 9.9 0.36 1.36e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg26516362 chr5:178986906 RUFY1 0.35 8.72 0.33 2.37e-17 Lung cancer; BRCA cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg24642439 chr20:33292090 TP53INP2 0.4 7.87 0.3 1.52e-14 Height; BRCA cis rs1949733 1.000 rs1949733 chr4:8503359 C/T cg11789530 chr4:8429930 ACOX3 -0.65 -16.87 -0.56 4.21e-53 Response to antineoplastic agents; BRCA cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg11663144 chr21:46675770 NA -0.61 -14.23 -0.49 4.28e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs1973993 0.745 rs7512263 chr1:96941158 C/A cg10631902 chr5:14652156 NA -0.48 -13.58 -0.47 4.28e-37 Weight; BRCA cis rs9283706 0.595 rs6866433 chr5:66324152 A/G cg11590213 chr5:66331682 MAST4 0.39 8.13 0.31 2.26e-15 Coronary artery disease; BRCA cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg26384229 chr12:38710491 ALG10B 0.69 15.69 0.53 3.64e-47 Bladder cancer; BRCA cis rs7267979 1.000 rs6138572 chr20:25435934 G/C cg08601574 chr20:25228251 PYGB 0.36 8.34 0.31 4.67e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg20607798 chr8:58055168 NA 0.56 8.64 0.32 4.37e-17 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6540559 0.673 rs6540564 chr1:210019910 T/C cg22029157 chr1:209979665 IRF6 0.44 8.33 0.31 4.95e-16 Cleft lip with or without cleft palate; BRCA cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg07549590 chr16:15018862 NA 0.5 12.55 0.44 1.98e-32 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg16423285 chr20:60520624 NA 0.44 8.34 0.31 4.57e-16 Body mass index; BRCA cis rs9359856 0.564 rs72915946 chr6:90447924 C/T cg13799429 chr6:90582589 CASP8AP2 -0.7 -8.43 -0.32 2.23e-16 Bipolar disorder; BRCA cis rs10789491 0.565 rs2897107 chr1:47206178 A/T cg15501359 chr1:47185051 KIAA0494 0.69 17.09 0.56 3.45e-54 Response to hepatitis C treatment; BRCA cis rs4595586 0.545 rs2218762 chr12:39397762 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.37 0.35 1.19e-19 Morning vs. evening chronotype; BRCA cis rs796364 1.000 rs281771 chr2:200812202 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.79 -13.54 -0.47 6.94e-37 Schizophrenia; BRCA cis rs9814567 1.000 rs1917130 chr3:134313773 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.45 0.61 1.5e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10193935 1.000 rs10195776 chr2:42425098 G/A cg27598129 chr2:42591480 NA -0.96 -15.3 -0.52 2.9e-45 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg11663144 chr21:46675770 NA -0.59 -13.79 -0.48 4.77e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs709400 0.628 rs6575983 chr14:103869849 C/G cg12935359 chr14:103987150 CKB -0.56 -13.96 -0.48 7.33e-39 Body mass index; BRCA cis rs11718455 0.960 rs11920021 chr3:44000856 T/C cg08738300 chr3:44038990 NA 0.44 8.67 0.32 3.42e-17 Coronary artery disease; BRCA trans rs6461049 0.800 rs3778977 chr7:2159746 C/T cg04565464 chr8:145669602 NFKBIL2 0.44 10.34 0.38 2.9e-23 Schizophrenia; BRCA cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg24531977 chr5:56204891 C5orf35 -0.86 -17.83 -0.58 4.82e-58 Initial pursuit acceleration; BRCA cis rs654351 0.541 rs533746 chr6:10388968 C/T cg17959970 chr6:10383164 NA 0.41 8.73 0.33 2.22e-17 Squamous cell lung carcinoma; BRCA cis rs290268 0.838 rs290989 chr9:93561836 T/C cg02608019 chr9:93564028 SYK 0.55 12.23 0.44 4.54e-31 Platelet count; BRCA cis rs477692 0.905 rs555545 chr10:131411586 G/A cg24747557 chr10:131355152 MGMT -0.32 -7.91 -0.3 1.15e-14 Response to temozolomide; BRCA cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg24642439 chr20:33292090 TP53INP2 -0.42 -8.6 -0.32 5.99e-17 Glomerular filtration rate (creatinine); BRCA cis rs911186 0.812 rs35454259 chr6:27254475 G/A cg12292205 chr6:26970375 C6orf41 -0.61 -10.09 -0.37 2.7e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs4727027 0.704 rs12704083 chr7:148909759 G/A cg23583168 chr7:148888333 NA -0.96 -25.3 -0.71 2.15e-98 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs634534 0.561 rs613924 chr11:65769295 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.61 13.64 0.47 2.35e-37 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs3771570 0.901 rs3815262 chr2:242352582 A/T cg21155796 chr2:242212141 HDLBP 0.46 8.04 0.3 4.47e-15 Prostate cancer; BRCA cis rs6964587 0.967 rs4626516 chr7:91807153 G/C cg17063962 chr7:91808500 NA 0.58 13.16 0.46 3.5e-35 Breast cancer; BRCA cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg12292205 chr6:26970375 C6orf41 0.74 17.4 0.57 8.19e-56 Autism spectrum disorder or schizophrenia; BRCA cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg22467129 chr15:76604101 ETFA -0.49 -10.72 -0.39 8.78e-25 Blood metabolite levels; BRCA trans rs61931739 0.534 rs7133262 chr12:34279444 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.51 0.35 3.85e-20 Morning vs. evening chronotype; BRCA cis rs6582630 0.622 rs11182004 chr12:38441254 G/A cg26384229 chr12:38710491 ALG10B -0.43 -10.04 -0.37 4.13e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs754466 0.605 rs10824578 chr10:79578244 G/C cg17075019 chr10:79541650 NA -0.86 -24.03 -0.69 2.09e-91 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.34 0.41 2.88e-27 Electroencephalogram traits; BRCA trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg11608241 chr8:8085544 FLJ10661 0.3 7.84 0.3 1.91e-14 Retinal vascular caliber; BRCA cis rs9325144 0.647 rs7957185 chr12:38909710 G/A cg26384229 chr12:38710491 ALG10B -0.52 -12.2 -0.43 6.61e-31 Morning vs. evening chronotype; BRCA cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg27446573 chr6:127587934 RNF146 0.88 20.71 0.63 2.59e-73 Breast cancer; BRCA cis rs7633770 0.965 rs6804112 chr3:46686248 C/T cg11219411 chr3:46661640 NA 0.65 15.48 0.52 3.71e-46 Coronary artery disease; BRCA cis rs2439831 0.850 rs28504496 chr15:44016883 C/T cg10011062 chr15:43941034 CATSPER2 -0.53 -7.82 -0.3 2.14e-14 Lung cancer in ever smokers; BRCA trans rs3733585 0.664 rs17185870 chr4:9958214 C/A cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.14e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs11098499 0.955 rs11931312 chr4:120159023 T/C cg25214090 chr10:38739885 LOC399744 0.48 10.63 0.39 2.06e-24 Corneal astigmatism; BRCA cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg24006582 chr15:45444508 DUOX1 0.55 10.72 0.39 8.88e-25 Uric acid levels; BRCA cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.15 0.31 1.95e-15 Axial length; BRCA cis rs2652834 0.904 rs2937859 chr15:63366282 C/T cg05507819 chr15:63340323 TPM1 0.54 9.86 0.36 1.94e-21 HDL cholesterol; BRCA cis rs6570726 0.720 rs412623 chr6:145883257 C/A cg23711669 chr6:146136114 FBXO30 0.71 16.84 0.55 6.04e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs72634258 0.554 rs12061787 chr1:7888730 G/C cg26816564 chr1:7831052 VAMP3 0.69 12.74 0.45 2.62e-33 Inflammatory bowel disease; BRCA cis rs7103648 0.897 rs11606287 chr11:47407439 C/A cg03711944 chr11:47377212 SPI1 -0.47 -12.01 -0.43 4.14e-30 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 19.88 0.62 8.05e-69 Platelet count; BRCA cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg01849466 chr14:104193079 ZFYVE21 -0.41 -10.4 -0.38 1.6e-23 Schizophrenia; BRCA cis rs796364 0.951 rs3098341 chr2:200792498 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.28 0.46 1.07e-35 Schizophrenia; BRCA cis rs10883723 0.962 rs1056741 chr10:104236640 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.6 17.02 0.56 7.29e-54 Allergic disease (asthma, hay fever or eczema); BRCA trans rs208520 0.954 rs1468153 chr6:67009054 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 11.67 0.42 1.16e-28 Exhaled nitric oxide output; BRCA cis rs2625529 0.938 rs2723343 chr15:72108269 C/T cg16672083 chr15:72433130 SENP8 -0.81 -16.22 -0.54 7.98e-50 Red blood cell count; BRCA cis rs754466 0.580 rs2289311 chr10:79565655 G/A cg17075019 chr10:79541650 NA -0.76 -18.94 -0.6 8.15e-64 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg14530993 chr4:882597 GAK 0.51 8.59 0.32 6.49e-17 Parkinson's disease; BRCA cis rs875971 0.964 rs9691480 chr7:65944306 A/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg12219531 chr12:120966889 COQ5 0.53 11.52 0.41 4.88e-28 High light scatter reticulocyte count; BRCA cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.97 0.37 7.08e-22 Bladder cancer; BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg21951975 chr1:209979733 IRF6 0.54 18.1 0.58 2.13e-59 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs6545883 0.507 rs12478192 chr2:61591175 A/G cg15711740 chr2:61764176 XPO1 0.32 7.91 0.3 1.16e-14 Tuberculosis; BRCA cis rs11971779 0.680 rs7792752 chr7:139066196 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs1568889 1.000 rs7102106 chr11:28343953 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 13.13 0.46 4.84e-35 Bipolar disorder; BRCA cis rs400736 0.562 rs12711516 chr1:8181227 G/C cg25007680 chr1:8021821 PARK7 -0.36 -8.68 -0.32 3.21e-17 Response to antidepressants and depression; BRCA cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg24642844 chr7:1081250 C7orf50 -0.94 -12.4 -0.44 8.46e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs250677 0.687 rs2963484 chr5:148451127 A/T cg23229984 chr5:148520753 ABLIM3 0.36 8.79 0.33 1.34e-17 Breast cancer; BRCA trans rs11098499 0.909 rs17046118 chr4:120387496 T/G cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg23505145 chr19:12996616 KLF1 -0.54 -11.66 -0.42 1.26e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg27029518 chr18:72166324 CNDP2 -0.31 -8.68 -0.32 3.35e-17 Refractive error; BRCA cis rs80130819 0.515 rs1793912 chr12:48387052 A/C cg05342945 chr12:48394962 COL2A1 -0.47 -9.34 -0.35 1.52e-19 Prostate cancer; BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.36 -0.35 1.29e-19 Total body bone mineral density; BRCA cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg05347473 chr6:146136440 FBXO30 -0.46 -9.26 -0.34 3.08e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6942756 0.806 rs2718093 chr7:128939582 G/A cg02491457 chr7:128862824 NA -0.56 -11.81 -0.42 2.99e-29 White matter hyperintensity burden; BRCA cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 4.98e-18 Motion sickness; BRCA cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg26384229 chr12:38710491 ALG10B 0.69 15.69 0.53 3.64e-47 Bladder cancer; BRCA cis rs3849570 0.922 rs3772895 chr3:81769493 A/G cg07356753 chr3:81810745 GBE1 -0.47 -11.38 -0.41 1.97e-27 Waist circumference;Body mass index; BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 12.51 0.44 2.84e-32 Platelet count; BRCA cis rs17253792 0.822 rs8009239 chr14:56062490 A/G cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs12310956 0.532 rs11052935 chr12:33970946 C/T cg06521331 chr12:34319734 NA -0.57 -11.15 -0.4 1.67e-26 Morning vs. evening chronotype; BRCA trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.2 -0.34 4.88e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6866344 0.661 rs72812606 chr5:178129094 A/T cg03877680 chr5:178157825 ZNF354A 0.79 14.61 0.5 6.69e-42 Neutrophil percentage of white cells; BRCA cis rs36051895 0.554 rs11789744 chr9:5134213 G/A cg02405213 chr9:5042618 JAK2 -0.47 -8.59 -0.32 6.52e-17 Pediatric autoimmune diseases; BRCA cis rs600806 0.815 rs10858094 chr1:109950858 T/C cg20591472 chr1:110008990 SYPL2 0.33 8.28 0.31 7.1e-16 Intelligence (multi-trait analysis); BRCA cis rs919433 0.963 rs4850430 chr2:198182796 A/T cg10820045 chr2:198174542 NA -0.38 -7.86 -0.3 1.66e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg14983838 chr19:29218262 NA 0.54 10.06 0.37 3.51e-22 Methadone dose in opioid dependence; BRCA cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg18016565 chr1:150552671 MCL1 0.35 8.01 0.3 5.26e-15 Melanoma; BRCA cis rs8030485 0.728 rs28415942 chr15:79384850 C/T cg17916960 chr15:79447300 NA 0.34 7.91 0.3 1.17e-14 Left ventricle wall thickness; BRCA trans rs61931739 0.534 rs1826144 chr12:34094272 A/G cg26384229 chr12:38710491 ALG10B 0.68 14.09 0.49 1.77e-39 Morning vs. evening chronotype; BRCA cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.08e-32 Breast cancer; BRCA cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs1005277 0.579 rs2505194 chr10:38393881 C/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.68 -0.55 3.81e-52 Extrinsic epigenetic age acceleration; BRCA cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24110177 chr3:50126178 RBM5 0.37 10.01 0.37 5.15e-22 Intelligence (multi-trait analysis); BRCA cis rs6450176 1.000 rs4311394 chr5:53300662 A/G ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.09 -0.51 3.14e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs61931739 0.534 rs28548399 chr12:34188151 G/A cg06521331 chr12:34319734 NA -0.63 -11.57 -0.42 2.98e-28 Morning vs. evening chronotype; BRCA cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg13010199 chr12:38710504 ALG10B 0.42 8.96 0.33 3.52e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg18876405 chr7:65276391 NA -0.5 -11.2 -0.41 1.06e-26 Aortic root size; BRCA cis rs9815354 0.812 rs967619 chr3:41876710 C/G cg03022575 chr3:42003672 ULK4 0.71 9.71 0.36 7.25e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg23029597 chr12:123009494 RSRC2 -0.48 -10.09 -0.37 2.62e-22 Body mass index; BRCA cis rs4566357 0.595 rs6707286 chr2:227911400 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -8.12 -0.31 2.34e-15 Coronary artery disease; BRCA trans rs7618501 0.602 rs2240327 chr3:50113034 C/T cg21659725 chr3:3221576 CRBN 0.48 12.67 0.45 5.72e-33 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.12 0.31 2.48e-15 Menopause (age at onset); BRCA cis rs61931739 0.534 rs4931772 chr12:34044590 G/A cg06521331 chr12:34319734 NA -0.63 -12.2 -0.43 6.34e-31 Morning vs. evening chronotype; BRCA cis rs2777491 1.000 rs2730057 chr15:41736275 C/A cg18705301 chr15:41695430 NDUFAF1 -0.69 -16.62 -0.55 7.96e-52 Ulcerative colitis; BRCA cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg16049864 chr8:95962084 TP53INP1 -0.49 -12.03 -0.43 3.43e-30 Type 2 diabetes; BRCA cis rs3772130 0.775 rs6769102 chr3:121560722 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.74 0.39 7.27e-25 Cognitive performance; BRCA cis rs4566357 0.539 rs10933164 chr2:227860671 A/G cg05526886 chr2:227700861 RHBDD1 -0.54 -9.46 -0.35 6.02e-20 Coronary artery disease; BRCA cis rs9291683 0.566 rs13144709 chr4:10044182 C/T cg00071950 chr4:10020882 SLC2A9 0.55 13.19 0.46 2.62e-35 Bone mineral density; BRCA cis rs6138458 1.000 rs6114984 chr20:24976610 A/G cg06937882 chr20:24974362 C20orf3 -0.48 -9.46 -0.35 5.84e-20 Blood protein levels; BRCA cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg16339924 chr4:17578868 LAP3 0.62 15.46 0.52 4.72e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg00166722 chr3:10149974 C3orf24 0.65 11.36 0.41 2.25e-27 Alzheimer's disease; BRCA cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg12927641 chr6:109611667 NA -0.36 -8.87 -0.33 7.18e-18 Reticulocyte fraction of red cells; BRCA cis rs1983170 0.736 rs12127718 chr1:91997490 A/T cg25838465 chr1:92012736 NA 0.48 8.23 0.31 1.05e-15 Eosinophil percentage of white cells; BRCA cis rs7945718 0.934 rs7114040 chr11:12781659 C/T cg25843174 chr11:12811716 TEAD1 -0.22 -8.63 -0.32 5.02e-17 Educational attainment (years of education); BRCA cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg23583168 chr7:148888333 NA -0.81 -19.71 -0.61 6.31e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6754311 0.731 rs1470457 chr2:136581848 A/G cg07169764 chr2:136633963 MCM6 0.76 16.32 0.54 2.74e-50 Mosquito bite size; BRCA cis rs1122900 1.000 rs1122900 chr5:36689181 A/C cg24186104 chr5:36689192 NA -0.37 -9.53 -0.35 3.31e-20 Aggressive periodontitis; BRCA cis rs11250464 0.833 rs11250467 chr10:1409662 A/G cg08668359 chr10:1443807 ADARB2 0.48 9.36 0.35 1.35e-19 Radiation response; BRCA cis rs9287719 0.870 rs10167676 chr2:10753140 G/A cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs6964587 1.000 rs2188154 chr7:91595138 T/A cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.68e-31 Breast cancer; BRCA cis rs7312933 0.966 rs6582375 chr12:42423185 A/T cg17420585 chr12:42539391 GXYLT1 -0.49 -10.56 -0.39 3.75e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg10556349 chr10:835070 NA 0.63 8.74 0.33 2.06e-17 Eosinophil percentage of granulocytes; BRCA cis rs7818345 0.845 rs4256608 chr8:19267560 A/G cg11303988 chr8:19266685 CSGALNACT1 0.35 8.72 0.33 2.31e-17 Language performance in older adults (adjusted for episodic memory); BRCA cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg11266682 chr4:10021025 SLC2A9 0.46 12.25 0.44 3.89e-31 Bone mineral density; BRCA cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.61e-52 Bone mineral density; BRCA cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg00074818 chr8:8560427 CLDN23 0.37 8.22 0.31 1.11e-15 Obesity-related traits; BRCA cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg26384229 chr12:38710491 ALG10B -0.61 -14.85 -0.51 4.28e-43 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.74e-36 Chronic sinus infection; BRCA cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg09658497 chr7:2847517 GNA12 -0.41 -8.48 -0.32 1.62e-16 Height; BRCA cis rs3125734 0.633 rs4979782 chr10:63998527 C/T cg19640130 chr10:64028056 RTKN2 -0.28 -8.1 -0.31 2.75e-15 Rheumatoid arthritis; BRCA trans rs2665103 0.589 rs2134046 chr15:82524544 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.31 -7.87 -0.3 1.52e-14 Intelligence (multi-trait analysis); BRCA cis rs2625529 0.730 rs1481860 chr15:72241857 T/C cg16672083 chr15:72433130 SENP8 0.72 16.73 0.55 2.17e-52 Red blood cell count; BRCA cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg06028605 chr16:24865363 SLC5A11 0.33 7.83 0.3 2.05e-14 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.562 rs11770061 chr7:107071310 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.18 -0.31 1.58e-15 Coronary artery disease; BRCA cis rs6820391 1.000 rs6820391 chr4:54414696 G/T cg04173182 chr4:54446035 LNX1 0.4 8.34 0.31 4.67e-16 Cervical artery dissection; BRCA cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.48 -9.12 -0.34 9.75e-19 Chronic sinus infection; BRCA cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg24110177 chr3:50126178 RBM5 0.4 10.89 0.4 1.83e-25 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.85 -0.3 1.81e-14 Aortic root size; BRCA cis rs55788414 0.932 rs9929253 chr16:81181641 C/T cg06400318 chr16:81190750 PKD1L2 -0.46 -7.99 -0.3 6.22e-15 Left ventricular obstructive tract defect (maternal effect); BRCA cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -13.99 -0.48 5.6e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg12463550 chr7:65579703 CRCP -0.36 -7.83 -0.3 2.06e-14 Aortic root size; BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg08742575 chr21:47604166 C21orf56 0.4 7.83 0.3 2e-14 Testicular germ cell tumor; BRCA cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg04450456 chr4:17643702 FAM184B 0.33 9.49 0.35 4.5e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg14983838 chr19:29218262 NA 0.54 10.19 0.37 1.07e-22 Methadone dose in opioid dependence; BRCA cis rs3820928 0.874 rs10189579 chr2:227864876 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.37 -0.31 3.62e-16 Pulmonary function; BRCA cis rs6882046 0.513 rs1081158 chr5:88004616 C/T cg22951263 chr5:87985283 NA -0.39 -11.01 -0.4 5.96e-26 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.27 -0.31 7.52e-16 Total body bone mineral density; BRCA cis rs332507 0.789 rs13097459 chr3:124398112 C/T cg05980111 chr3:124395277 KALRN 0.38 8.58 0.32 6.93e-17 Plateletcrit; BRCA cis rs6582630 0.555 rs11503799 chr12:38294578 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.04 -0.37 3.86e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.7 0.33 2.91e-17 Tonsillectomy; BRCA cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.96 22.06 0.66 1.26e-80 Smoking behavior; BRCA cis rs67981189 0.752 rs221902 chr14:71601079 G/T cg15816911 chr14:71606274 NA -0.36 -8.09 -0.3 2.96e-15 Schizophrenia; BRCA cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg18963800 chr10:38644991 HSD17B7P2 -0.42 -8.12 -0.31 2.35e-15 Extrinsic epigenetic age acceleration; BRCA cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg21573476 chr21:45109991 RRP1B -0.4 -11.16 -0.4 1.54e-26 Mean corpuscular volume; BRCA cis rs35306767 0.714 rs11250228 chr10:1074887 A/G cg26597838 chr10:835615 NA 0.65 11.02 0.4 5.44e-26 Eosinophil percentage of granulocytes; BRCA cis rs7903847 0.596 rs7922512 chr10:99155685 C/A cg20016023 chr10:99160130 RRP12 -0.26 -8.53 -0.32 1.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg22903471 chr2:27725779 GCKR -0.4 -9.82 -0.36 2.6e-21 Total body bone mineral density; BRCA cis rs172166 0.694 rs1150666 chr6:28123928 T/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.17 0.31 1.68e-15 Cardiac Troponin-T levels; BRCA cis rs672059 1.000 rs575474 chr1:183158599 T/C ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.28e-17 Hypertriglyceridemia; BRCA trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.16 0.31 1.74e-15 Corneal astigmatism; BRCA cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg08564027 chr20:61660810 NA 0.85 22.85 0.67 6.19e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg11742103 chr11:62369870 EML3;MTA2 0.52 12.61 0.45 1.06e-32 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg02079420 chr8:82753780 SNX16 0.31 8.44 0.32 2.1e-16 Diastolic blood pressure; BRCA cis rs6973256 0.865 rs11975290 chr7:133335144 C/A cg07491979 chr7:133331646 EXOC4 -0.39 -8.91 -0.33 5.11e-18 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11112613 0.713 rs73184083 chr12:105952593 T/A cg03607813 chr12:105948248 NA 0.55 10.43 0.38 1.25e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs3812049 0.784 rs1560637 chr5:127448066 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.57 10.65 0.39 1.78e-24 Lymphocyte counts;Red cell distribution width; BRCA cis rs28735056 0.933 rs499472 chr18:77589759 C/T cg20368463 chr18:77673604 PQLC1 -0.34 -8.08 -0.3 3.36e-15 Schizophrenia; BRCA cis rs372883 0.648 rs11088117 chr21:30737816 G/C cg24692254 chr21:30365293 RNF160 0.42 9.6 0.35 1.81e-20 Pancreatic cancer; BRCA cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg11812906 chr14:75593930 NEK9 0.65 15.01 0.51 7.86e-44 Height; BRCA cis rs1506636 1.000 rs646753 chr7:123401237 G/T cg03229431 chr7:123269106 ASB15 0.61 13.78 0.48 4.97e-38 Plateletcrit;Platelet count; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg10862848 chr6:42927986 GNMT 0.31 13.75 0.48 7.51e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg12386194 chr3:101231763 SENP7 0.46 9.57 0.35 2.36e-20 Colorectal cancer; BRCA cis rs796364 1.000 rs281783 chr2:200751582 G/A cg23649088 chr2:200775458 C2orf69 0.6 8.89 0.33 6.23e-18 Schizophrenia; BRCA cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.14 0.37 1.71e-22 Aortic root size; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg23978390 chr7:1156363 C7orf50 0.34 8.08 0.3 3.19e-15 Longevity;Endometriosis; BRCA cis rs68170813 0.559 rs7804979 chr7:106999453 C/G cg02696742 chr7:106810147 HBP1 -0.49 -8.27 -0.31 7.91e-16 Coronary artery disease; BRCA cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg00071950 chr4:10020882 SLC2A9 0.52 12.35 0.44 1.46e-31 Bone mineral density; BRCA cis rs8030485 0.536 rs12595749 chr15:79432359 A/G cg17916960 chr15:79447300 NA 0.39 9.6 0.36 1.75e-20 Left ventricle wall thickness; BRCA cis rs887829 0.569 rs3806597 chr2:234637569 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.31 8.24 0.31 9.9e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg02659138 chr7:134003124 SLC35B4 0.34 10.72 0.39 9.27e-25 Mean platelet volume; BRCA cis rs597539 0.617 rs598353 chr11:68635770 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.6 0.55 9.86e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg12573674 chr2:1569213 NA 0.5 9.38 0.35 1.12e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6582630 0.555 rs10880612 chr12:38509427 A/G cg13010199 chr12:38710504 ALG10B 0.52 10.81 0.39 3.81e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg24642439 chr20:33292090 TP53INP2 0.4 8.02 0.3 4.97e-15 Height; BRCA trans rs2204008 0.626 rs11520260 chr12:38330092 C/T cg06521331 chr12:34319734 NA -0.48 -8.79 -0.33 1.39e-17 Bladder cancer; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg07308232 chr7:1071921 C7orf50 -0.36 -7.82 -0.3 2.16e-14 Longevity;Endometriosis; BRCA cis rs7666738 0.830 rs1426665 chr4:99027764 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.93 0.3 9.65e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs1459104 1.000 rs12793778 chr11:55085722 T/C cg15704280 chr7:45808275 SEPT13 0.7 8.7 0.33 2.73e-17 Body mass index; BRCA cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg24060327 chr5:131705240 SLC22A5 0.51 10.66 0.39 1.51e-24 Blood metabolite levels; BRCA cis rs9942416 0.660 rs194137 chr5:74978857 G/A cg19683494 chr5:74908142 NA -0.48 -8.95 -0.33 3.81e-18 Age-related disease endophenotypes; BRCA cis rs1451375 0.617 rs1807066 chr7:50543683 T/C cg18232548 chr7:50535776 DDC -0.42 -8.76 -0.33 1.76e-17 Malaria; BRCA cis rs8038465 0.638 rs12591473 chr15:73967485 A/T cg15420318 chr15:73925796 NPTN 0.4 9.12 0.34 9.77e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg00983440 chr10:79422392 NA 0.57 10.73 0.39 8.59e-25 Bone mineral density; BRCA cis rs600231 0.719 rs7114809 chr11:65251444 A/G cg01292856 chr11:65242576 NA 0.33 8.3 0.31 6.08e-16 Bone mineral density; BRCA cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg18132916 chr6:79620363 NA -0.48 -10.88 -0.4 2.04e-25 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.699 rs6449159 chr4:9960498 G/A cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11098499 0.863 rs34868248 chr4:120442430 A/G cg09307838 chr4:120376055 NA 0.69 14.03 0.49 3.41e-39 Corneal astigmatism; BRCA cis rs7561273 0.609 rs6720226 chr2:24295853 A/G cg04809136 chr2:24300158 SF3B14 -0.4 -9.24 -0.34 3.46e-19 Quantitative traits; BRCA cis rs6912958 1.000 rs6937823 chr6:88160386 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -10.17 -0.37 1.26e-22 Monocyte percentage of white cells; BRCA cis rs523522 0.892 rs4767916 chr12:121024032 T/C cg27279351 chr12:120934652 DYNLL1 0.56 13.13 0.46 4.75e-35 High light scatter reticulocyte count; BRCA cis rs6840258 1.000 rs72667754 chr4:87942061 T/C cg08197287 chr4:87952173 AFF1 -0.44 -8.56 -0.32 8.22e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.95 0.37 8.73e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6121246 0.909 rs6058463 chr20:30385192 C/T cg13852791 chr20:30311386 BCL2L1 0.83 16.35 0.54 1.76e-50 Mean corpuscular hemoglobin; BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18758796 chr5:131593413 PDLIM4 0.36 9.47 0.35 5.38e-20 Breast cancer; BRCA cis rs11229555 0.598 rs12269888 chr11:58184336 T/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2901460 0.509 rs56944298 chr2:62090001 A/G cg02183531 chr2:62113199 CCT4 -0.45 -8.81 -0.33 1.18e-17 Mean corpuscular volume; BRCA cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.36 -0.31 4.07e-16 IgG glycosylation; BRCA cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg05623727 chr3:50126028 RBM5 0.44 10.43 0.38 1.25e-23 Intelligence (multi-trait analysis); BRCA cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg08493051 chr2:3487164 NA -0.4 -8.47 -0.32 1.67e-16 Neurofibrillary tangles; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.31e-16 Menopause (age at onset); BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.79 13.01 0.46 1.73e-34 Platelet count; BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg25036284 chr2:26402008 FAM59B 0.96 16.0 0.53 1.08e-48 Gut microbiome composition (summer); BRCA cis rs2243480 0.803 rs160649 chr7:65543199 C/T cg18252515 chr7:66147081 NA -0.99 -13.97 -0.48 6.87e-39 Diabetic kidney disease; BRCA cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.55 11.96 0.43 6.6e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14442939 chr10:27389572 ANKRD26 -0.68 -10.86 -0.39 2.56e-25 Breast cancer; BRCA cis rs754466 0.580 rs10430530 chr10:79582812 T/C cg17075019 chr10:79541650 NA -0.83 -21.89 -0.65 1.06e-79 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4363385 0.747 rs1415959 chr1:152973690 C/T cg24667326 chr1:152973720 SPRR3 0.35 9.98 0.37 6.96e-22 Inflammatory skin disease; BRCA cis rs847577 0.748 rs55784506 chr7:97718201 G/A cg21770322 chr7:97807741 LMTK2 0.58 17.05 0.56 5.41e-54 Breast cancer; BRCA cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg15128208 chr22:42549153 NA -0.31 -7.96 -0.3 7.78e-15 Cognitive function; BRCA cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.541 rs523937 chr2:219437596 G/C cg10223061 chr2:219282414 VIL1 -0.27 -8.1 -0.31 2.71e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs6882046 0.513 rs679232 chr5:88054763 A/C cg22951263 chr5:87985283 NA 0.38 10.69 0.39 1.18e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA trans rs6582630 0.537 rs1949611 chr12:38373092 C/T cg06521331 chr12:34319734 NA 0.46 9.08 0.34 1.35e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs765787 0.530 rs2668737 chr15:45522799 C/T cg15395560 chr15:45543142 SLC28A2 0.29 8.27 0.31 7.75e-16 Uric acid levels; BRCA cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA trans rs4332037 0.707 rs56070303 chr7:1891015 C/T cg11693508 chr17:37793320 STARD3 0.6 11.11 0.4 2.42e-26 Bipolar disorder; BRCA cis rs9467773 0.967 rs6932865 chr6:26540166 C/A cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs9359856 0.510 rs17293240 chr6:90396370 C/T cg13799429 chr6:90582589 CASP8AP2 0.71 11.17 0.4 1.41e-26 Bipolar disorder; BRCA cis rs595982 0.517 rs4801779 chr19:49406651 T/G cg21252483 chr19:49399788 TULP2 -0.27 -8.39 -0.31 3.17e-16 Red cell distribution width; BRCA cis rs12586317 0.547 rs60152856 chr14:35421373 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.08 -0.37 2.75e-22 Psoriasis; BRCA trans rs453301 0.658 rs6983877 chr8:8904639 T/C cg21775007 chr8:11205619 TDH -0.38 -7.83 -0.3 2.01e-14 Joint mobility (Beighton score); BRCA cis rs2635047 1.000 rs2635045 chr18:44668417 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -8.38 -0.31 3.27e-16 Educational attainment; BRCA trans rs208520 1.000 rs12191598 chr6:66983962 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.49 0.5 2.5e-41 Exhaled nitric oxide output; BRCA cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.72e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg17372223 chr3:52568218 NT5DC2 0.35 8.17 0.31 1.62e-15 Electroencephalogram traits; BRCA cis rs67981189 0.896 rs2526874 chr14:71381219 G/A cg15816911 chr14:71606274 NA -0.37 -8.17 -0.31 1.65e-15 Schizophrenia; BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.67 0.42 1.15e-28 Tonsillectomy; BRCA cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg05084668 chr3:125655381 ALG1L -0.49 -9.3 -0.35 2.24e-19 Blood pressure (smoking interaction); BRCA cis rs36051895 0.632 rs10815166 chr9:5149920 T/G cg02405213 chr9:5042618 JAK2 -0.44 -8.6 -0.32 6.14e-17 Pediatric autoimmune diseases; BRCA cis rs936229 0.768 rs12442901 chr15:75083912 A/G cg10253484 chr15:75165896 SCAMP2 -0.53 -10.13 -0.37 1.84e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg24675658 chr1:53192096 ZYG11B 0.56 12.72 0.45 3.45e-33 Monocyte count; BRCA cis rs425277 1.000 rs262670 chr1:2082458 C/T cg00981070 chr1:2046702 PRKCZ 0.31 8.31 0.31 5.81e-16 Height; BRCA cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg12751644 chr20:60527061 NA -0.33 -7.95 -0.3 8.19e-15 Body mass index; BRCA cis rs7582720 1.000 rs72936323 chr2:204050474 T/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.25 0.44 3.99e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg22467129 chr15:76604101 ETFA 0.45 10.04 0.37 4.08e-22 Blood metabolite levels; BRCA cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.821 rs55948613 chr2:24094787 A/G cg08917208 chr2:24149416 ATAD2B 0.61 10.3 0.38 4.02e-23 Lymphocyte counts; BRCA cis rs220324 0.647 rs55877840 chr21:43560383 T/C cg09727148 chr21:43560719 UMODL1 0.5 8.88 0.33 6.65e-18 Idiopathic osteonecrosis of the femoral head; BRCA cis rs1215050 0.740 rs783929 chr4:98972495 T/A cg05340658 chr4:99064831 C4orf37 -0.49 -11.35 -0.41 2.46e-27 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg26597838 chr10:835615 NA 0.91 16.21 0.54 9.27e-50 Eosinophil percentage of granulocytes; BRCA cis rs7020830 0.931 rs6476613 chr9:37084340 A/G cg14294708 chr9:37120828 ZCCHC7 1.09 33.86 0.8 1.04e-144 Schizophrenia; BRCA cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg10556349 chr10:835070 NA -0.61 -8.4 -0.32 2.82e-16 Eosinophil percentage of granulocytes; BRCA trans rs9291683 0.588 rs6844329 chr4:10018544 T/C cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.34e-16 Bone mineral density; BRCA cis rs2637030 0.559 rs256117 chr5:52916684 G/A cg06476337 chr5:52856530 NDUFS4 0.38 8.82 0.33 1.09e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs11112613 0.775 rs7299470 chr12:105961773 G/A cg03607813 chr12:105948248 NA 0.53 10.23 0.38 7.36e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs4588572 0.643 rs13155648 chr5:77755343 A/G cg11547950 chr5:77652471 NA -0.47 -8.36 -0.31 4e-16 Triglycerides; BRCA cis rs8028182 0.636 rs8036884 chr15:75862893 T/C cg20655648 chr15:75932815 IMP3 0.45 8.83 0.33 1.01e-17 Sudden cardiac arrest; BRCA cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg26384229 chr12:38710491 ALG10B 0.69 15.69 0.53 3.64e-47 Bladder cancer; BRCA cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg14844989 chr11:31128820 NA -0.44 -9.27 -0.34 2.83e-19 Red blood cell count; BRCA cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg12219531 chr12:120966889 COQ5 0.55 11.42 0.41 1.25e-27 High light scatter reticulocyte count; BRCA cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg11822812 chr5:140052017 DND1 -0.31 -8.4 -0.32 2.86e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg14036092 chr11:66035641 RAB1B 0.39 10.25 0.38 6.51e-23 Gout; BRCA cis rs3796619 0.961 rs11732520 chr4:1074009 C/T cg27284194 chr4:1044797 NA 0.43 9.38 0.35 1.09e-19 Recombination rate (males); BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.24e-18 Tonsillectomy; BRCA cis rs2635047 0.967 rs2576030 chr18:44659166 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 8.93 0.33 4.39e-18 Educational attainment; BRCA cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg20887711 chr4:1340912 KIAA1530 0.72 15.92 0.53 2.56e-48 Longevity; BRCA cis rs2505998 0.957 rs2506005 chr10:43581980 C/T cg15436174 chr10:43711423 RASGEF1A -0.4 -7.96 -0.3 7.77e-15 Hirschsprung disease; BRCA trans rs11098499 0.618 rs35265692 chr4:120325135 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.14 0.31 2.02e-15 Corneal astigmatism; BRCA cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg27446573 chr6:127587934 RNF146 0.69 14.93 0.51 1.83e-43 Breast cancer; BRCA cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg26597838 chr10:835615 NA 0.98 17.24 0.56 5.71e-55 Eosinophil percentage of granulocytes; BRCA cis rs2243480 1.000 rs383402 chr7:65586653 A/C cg18252515 chr7:66147081 NA 0.97 14.42 0.5 5.43e-41 Diabetic kidney disease; BRCA cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg18357645 chr12:58087776 OS9 0.43 12.09 0.43 1.85e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs2289583 0.642 rs8034281 chr15:75384227 A/G cg14664628 chr15:75095509 CSK -0.38 -8.8 -0.33 1.26e-17 Systemic lupus erythematosus; BRCA cis rs4595586 0.545 rs1562729 chr12:39406179 T/G cg26384229 chr12:38710491 ALG10B 0.42 9.5 0.35 4.14e-20 Morning vs. evening chronotype; BRCA trans rs2832077 0.527 rs2705690 chr21:30239245 T/A cg14791747 chr16:20752902 THUMPD1 -0.41 -12.58 -0.45 1.47e-32 Cognitive test performance; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.26e-20 Alzheimer's disease; BRCA cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg14196790 chr5:131705035 SLC22A5 0.3 7.85 0.3 1.73e-14 Blood metabolite levels; BRCA cis rs1801251 0.644 rs283473 chr2:233654847 A/G cg25237894 chr2:233734115 C2orf82 0.31 9.04 0.34 1.91e-18 Coronary artery disease; BRCA cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs7018 chr20:25278261 A/G cg08601574 chr20:25228251 PYGB 0.34 8.35 0.31 4.15e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs2797160 1.000 rs2747719 chr6:126009214 C/T cg05039488 chr6:79577232 IRAK1BP1 0.36 8.07 0.3 3.49e-15 Endometrial cancer; BRCA cis rs7617773 0.743 rs7621785 chr3:48343708 T/C cg11946769 chr3:48343235 NME6 0.68 13.73 0.48 9.09e-38 Coronary artery disease; BRCA cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg21573476 chr21:45109991 RRP1B -0.35 -9.04 -0.34 1.92e-18 Mean corpuscular volume; BRCA cis rs9787249 0.957 rs11206754 chr1:40216234 A/G cg24920358 chr1:40204285 PPIE 0.35 8.21 0.31 1.25e-15 Blood protein levels; BRCA cis rs2637266 0.935 rs2583054 chr10:78401442 A/G cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA trans rs877282 0.853 rs7079299 chr10:756455 A/G cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs6484504 0.576 rs2447671 chr11:31334323 A/G cg26647111 chr11:31128758 NA -0.39 -8.65 -0.32 4.1e-17 Red blood cell count; BRCA cis rs12618769 0.625 rs72821955 chr2:99159792 G/A cg10123293 chr2:99228465 UNC50 0.44 8.57 0.32 7.88e-17 Bipolar disorder; BRCA cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.68 0.45 4.89e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs36051895 0.659 rs11999076 chr9:5037694 C/T cg02405213 chr9:5042618 JAK2 -0.5 -9.36 -0.35 1.36e-19 Pediatric autoimmune diseases; BRCA cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg23719950 chr11:63933701 MACROD1 -0.59 -9.69 -0.36 8.6e-21 Mean platelet volume; BRCA cis rs208520 0.661 rs207079 chr6:66770462 C/T cg07460842 chr6:66804631 NA -1.01 -20.27 -0.63 6.22e-71 Exhaled nitric oxide output; BRCA cis rs57677839 1 rs57677839 chr11:17028189 G/A cg14707162 chr11:17036581 PLEKHA7 -0.38 -9.51 -0.35 3.95e-20 Coronary artery disease; BRCA cis rs7607369 0.648 rs7559490 chr2:219656867 A/T cg02176678 chr2:219576539 TTLL4 -0.47 -12.25 -0.44 4e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg23708337 chr7:1209742 NA 0.5 9.78 0.36 3.7e-21 Longevity;Endometriosis; BRCA cis rs4074536 0.574 rs10737734 chr1:116292091 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.66 -0.32 3.83e-17 QRS duration; BRCA cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg08999081 chr20:33150536 PIGU 0.42 11.85 0.42 1.97e-29 Glomerular filtration rate (creatinine); BRCA cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.7 0.39 1.09e-24 Bipolar disorder; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg09436375 chr6:42928200 GNMT -0.3 -10.86 -0.39 2.6e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6005807 0.719 rs58542867 chr22:28988260 A/G cg12565055 chr22:29076175 TTC28 0.5 9.32 0.35 1.87e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg09455208 chr3:40491958 NA 0.39 9.25 0.34 3.24e-19 Renal cell carcinoma; BRCA cis rs10504073 0.669 rs341799 chr8:50036574 A/G cg00325661 chr8:49890786 NA 0.38 10.89 0.4 1.81e-25 Blood metabolite ratios; BRCA cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg16743903 chr16:89593216 SPG7 -0.34 -8.53 -0.32 1.09e-16 Multiple myeloma (IgH translocation); BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg24829409 chr8:58192753 C8orf71 -0.5 -8.24 -0.31 1e-15 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg10495392 chr1:46806563 NSUN4 0.45 8.41 0.32 2.59e-16 Menopause (age at onset); BRCA trans rs9329221 0.527 rs34308302 chr8:10332022 C/T cg15556689 chr8:8085844 FLJ10661 -0.35 -8.81 -0.33 1.18e-17 Neuroticism; BRCA trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg26384229 chr12:38710491 ALG10B 0.74 16.45 0.55 5.77e-51 Morning vs. evening chronotype; BRCA trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg23533926 chr12:111358616 MYL2 -0.43 -9.14 -0.34 8.32e-19 Extrinsic epigenetic age acceleration; BRCA cis rs7975161 0.630 rs7138317 chr12:104650271 G/A cg25273343 chr12:104657179 TXNRD1 -0.6 -9.34 -0.35 1.5700000000000001e-19 Toenail selenium levels; BRCA cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg23711669 chr6:146136114 FBXO30 0.78 18.67 0.59 1.96e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs2120243 0.935 rs9681270 chr3:157143996 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.41 8.96 0.33 3.68e-18 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs7666738 0.830 rs7672901 chr4:98938781 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.52 0.55 2.45e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs4690686 0.500 rs4690431 chr4:177264251 G/A cg17059388 chr4:177262070 NA 0.51 10.68 0.39 1.34e-24 Essential tremor; BRCA cis rs11690935 0.959 rs11897196 chr2:172585595 G/A cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.46 -0.77 1.51e-126 Schizophrenia; BRCA cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg15017067 chr4:17643749 FAM184B -0.28 -8.06 -0.3 3.79e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2762353 0.904 rs13197514 chr6:25785991 C/T cg03264133 chr6:25882463 NA 0.51 11.35 0.41 2.49e-27 Blood metabolite levels; BRCA cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg24812749 chr6:127587940 RNF146 0.69 15.21 0.52 8.24e-45 Breast cancer; BRCA cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg14963724 chr18:72166303 CNDP2 -0.34 -9.48 -0.35 4.94e-20 Refractive error; BRCA cis rs7524258 0.900 rs6577426 chr1:7306451 A/G cg07173049 chr1:7289937 CAMTA1 0.4 9.79 0.36 3.41e-21 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg12826209 chr6:26865740 GUSBL1 0.59 9.97 0.37 7.36e-22 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg08888203 chr3:10149979 C3orf24 0.61 12.47 0.44 4.3e-32 Alzheimer's disease; BRCA cis rs6545883 0.859 rs62149714 chr2:61603869 T/G cg15711740 chr2:61764176 XPO1 0.5 12.18 0.43 8.05e-31 Tuberculosis; BRCA cis rs490234 0.718 rs2133386 chr9:128173838 C/A cg14078157 chr9:128172775 NA -0.35 -7.91 -0.3 1.13e-14 Mean arterial pressure; BRCA cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.42 0.32 2.42e-16 Bladder cancer; BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26314531 chr2:26401878 FAM59B -0.66 -11.29 -0.41 4.42e-27 Gut microbiome composition (summer); BRCA cis rs7903847 0.642 rs10786339 chr10:99153076 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.54 -0.32 1.01e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs1949733 0.701 rs1880024 chr4:8454639 A/G cg11789530 chr4:8429930 ACOX3 0.59 14.69 0.5 2.68e-42 Response to antineoplastic agents; BRCA cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg26597838 chr10:835615 NA 0.95 14.86 0.51 4.14e-43 Eosinophil percentage of granulocytes; BRCA trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.93 0.3 1.01e-14 Corneal astigmatism; BRCA cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg21918786 chr6:109611834 NA -0.49 -14.04 -0.49 3.1e-39 Reticulocyte fraction of red cells; BRCA cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.11 0.4 2.39e-26 Prostate cancer (SNP x SNP interaction); BRCA trans rs61931739 0.500 rs34703942 chr12:34583776 T/C cg26384229 chr12:38710491 ALG10B -0.61 -13.88 -0.48 1.75e-38 Morning vs. evening chronotype; BRCA trans rs877282 0.533 rs10904565 chr10:819991 G/T cg22713356 chr15:30763199 NA 1.02 16.38 0.54 1.25e-50 Uric acid levels; BRCA cis rs7666738 0.830 rs6839203 chr4:98839814 C/G cg17366294 chr4:99064904 C4orf37 0.43 10.09 0.37 2.68e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg20503657 chr10:835505 NA 1.03 18.41 0.59 4.71e-61 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.09 0.49 1.94e-39 Motion sickness; BRCA trans rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05039488 chr6:79577232 IRAK1BP1 0.35 7.95 0.3 8.59e-15 Endometrial cancer; BRCA cis rs9467711 0.651 rs16891264 chr6:26072445 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC -0.57 -8.23 -0.31 1.09e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg04553112 chr3:125709451 NA -0.55 -8.34 -0.31 4.47e-16 Blood pressure (smoking interaction); BRCA cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.28 0.31 7.44e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs28374715 0.532 rs11070328 chr15:41651569 T/C cg18705301 chr15:41695430 NDUFAF1 -1.06 -26.3 -0.72 7.48e-104 Ulcerative colitis; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg10862848 chr6:42927986 GNMT -0.36 -15.01 -0.51 7.95e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7727544 0.735 rs272867 chr5:131681057 G/A cg24060327 chr5:131705240 SLC22A5 -0.49 -10.17 -0.37 1.28e-22 Blood metabolite levels; BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs61990749 0.597 rs2267768 chr14:78216014 A/G cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.97 0.3 7.44e-15 Fibroblast growth factor basic levels; BRCA cis rs4363385 0.720 rs1338179 chr1:152981548 T/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.11e-18 Inflammatory skin disease; BRCA cis rs7246657 0.722 rs13744 chr19:38077912 C/T cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs7809615 0.901 rs10235235 chr7:99075831 T/C cg12290671 chr7:99195819 NA -0.51 -8.85 -0.33 8.35e-18 Blood metabolite ratios; BRCA cis rs8177179 0.967 rs10935085 chr3:133459735 C/T cg24879335 chr3:133465180 TF 0.33 10.92 0.4 1.44e-25 Iron status biomarkers (transferrin levels); BRCA trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg26116260 chr4:7069785 GRPEL1 -0.85 -19.74 -0.62 4.23e-68 Monocyte percentage of white cells; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg04025307 chr7:1156635 C7orf50 0.77 20.46 0.63 5.91e-72 Longevity;Endometriosis; BRCA cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg17366294 chr4:99064904 C4orf37 0.52 11.16 0.4 1.48e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs1538970 0.781 rs11211139 chr1:46015751 G/T cg05343316 chr1:45956843 TESK2 0.7 13.85 0.48 2.33e-38 Platelet count; BRCA cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg19077165 chr18:44547161 KATNAL2 -0.5 -10.76 -0.39 6.06e-25 Personality dimensions; BRCA cis rs2294693 0.891 rs1072119 chr6:40993072 G/A cg14418226 chr6:40996092 UNC5CL 0.44 7.82 0.3 2.16e-14 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.5 -10.07 -0.37 3.07e-22 Tonsillectomy; BRCA cis rs700651 0.789 rs1371663 chr2:198900305 C/T cg00792783 chr2:198669748 PLCL1 -0.43 -9.17 -0.34 6.18e-19 Intracranial aneurysm; BRCA cis rs13191362 0.507 rs2846536 chr6:163033492 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.48 9.56 0.35 2.39e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3784262 0.669 rs3784257 chr15:58262974 C/T cg12031962 chr15:58353849 ALDH1A2 0.37 10.13 0.37 1.86e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs6582630 0.615 rs10880642 chr12:38554152 A/G cg26384229 chr12:38710491 ALG10B -0.41 -9.74 -0.36 5.31e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg08885076 chr2:99613938 TSGA10 0.44 10.47 0.38 9.11e-24 Chronic sinus infection; BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs6450176 0.830 rs7718193 chr5:53291591 T/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.06 -0.49 2.45e-39 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9467773 1.000 rs10946834 chr6:26533664 G/C cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs62458065 0.513 rs10268149 chr7:32575499 T/C cg20159608 chr7:32802032 NA -0.51 -9.77 -0.36 4.05e-21 Metabolite levels (HVA/MHPG ratio); BRCA cis rs9287719 0.934 rs12692416 chr2:10745627 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs8032158 0.963 rs1912398 chr15:56159103 T/G cg02198044 chr15:56286336 NEDD4 -0.37 -8.93 -0.33 4.47e-18 Keloid; BRCA cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg11366901 chr6:160182831 ACAT2 0.78 15.09 0.51 3.06e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg12310025 chr6:25882481 NA -0.54 -13.07 -0.46 9.5e-35 Blood metabolite levels; BRCA cis rs3771570 1.000 rs57196672 chr2:242235193 G/A cg21155796 chr2:242212141 HDLBP 0.59 8.96 0.33 3.43e-18 Prostate cancer; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg04234412 chr22:24373322 LOC391322 -0.58 -14.41 -0.5 6.03e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg01689657 chr7:91764605 CYP51A1 -0.22 -8.0 -0.3 6.03e-15 Breast cancer; BRCA cis rs17095355 1.000 rs56273398 chr10:111708183 C/T cg00817464 chr10:111662876 XPNPEP1 -0.36 -8.69 -0.33 3.07e-17 Biliary atresia; BRCA cis rs4321325 0.733 rs78516281 chr2:127944564 G/C cg11380483 chr2:127933992 NA 0.45 8.85 0.33 8.57e-18 Protein C levels; BRCA trans rs11039798 0.698 rs76315297 chr11:48240475 T/C cg15704280 chr7:45808275 SEPT13 0.55 8.11 0.31 2.57e-15 Axial length; BRCA cis rs12042938 0.600 rs1094655 chr1:231774362 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 8.88 0.33 6.48e-18 Neuranatomic and neurocognitive phenotypes; BRCA trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.42 -9.89 -0.36 1.43e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.65 -0.32 4.25e-17 Monocyte percentage of white cells; BRCA cis rs17685 0.753 rs1806885 chr7:75785612 T/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.92 0.4 1.47e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs7772486 0.754 rs6937661 chr6:146113299 T/C cg13319975 chr6:146136371 FBXO30 0.44 10.04 0.37 3.89e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg00677455 chr12:58241039 CTDSP2 0.5 11.13 0.4 1.94e-26 Intelligence (multi-trait analysis); BRCA cis rs5167 0.504 rs3760627 chr19:45457180 T/C cg09555818 chr19:45449301 APOC2 0.46 12.09 0.43 1.98e-30 Blood protein levels; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.1 -0.31 2.79e-15 Total body bone mineral density; BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg08470875 chr2:26401718 FAM59B -0.51 -8.24 -0.31 9.46e-16 Gut microbiome composition (summer); BRCA cis rs1865760 1.000 rs9348698 chr6:25929689 T/A cg16482183 chr6:26056742 HIST1H1C 0.54 11.1 0.4 2.7e-26 Height; BRCA cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg07395648 chr5:131743802 NA 0.37 9.28 0.34 2.49e-19 Blood metabolite levels; BRCA cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs6582630 0.539 rs35114325 chr12:38320886 G/T cg26384229 chr12:38710491 ALG10B -0.43 -9.85 -0.36 2.05e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg24692254 chr21:30365293 RNF160 -0.45 -10.06 -0.37 3.33e-22 Pancreatic cancer; BRCA cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg06784218 chr1:46089804 CCDC17 0.5 11.94 0.43 8.52e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10992471 0.651 rs2296669 chr9:95373790 A/G cg14631576 chr9:95140430 CENPP 0.33 8.1 0.31 2.81e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA trans rs3733585 0.638 rs17185835 chr4:9958180 T/G cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.14e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21659725 chr3:3221576 CRBN -0.71 -21.91 -0.65 8.31e-80 Intelligence (multi-trait analysis); BRCA cis rs9790314 1.000 rs1478565 chr3:161027464 C/T cg04691961 chr3:161091175 C3orf57 -0.59 -14.0 -0.48 4.87e-39 Morning vs. evening chronotype; BRCA cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg11843238 chr5:131593191 PDLIM4 -0.34 -7.84 -0.3 1.88e-14 Breast cancer; BRCA cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg01028140 chr2:1542097 TPO -0.62 -12.85 -0.45 8.52e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg05283184 chr6:79620031 NA -0.44 -11.24 -0.41 7.48e-27 Intelligence (multi-trait analysis); BRCA cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg05535760 chr7:792225 HEATR2 -0.74 -11.81 -0.42 2.94e-29 Cerebrospinal P-tau181p levels; BRCA cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg18225595 chr11:63971243 STIP1 0.43 10.97 0.4 9.19e-26 Platelet count; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg21782813 chr7:2030301 MAD1L1 0.43 12.34 0.44 1.53e-31 Bipolar disorder and schizophrenia; BRCA trans rs8002861 0.664 rs1808097 chr13:44424766 A/G cg12856521 chr11:46389249 DGKZ 0.37 8.11 0.31 2.5e-15 Leprosy; BRCA cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 19.84 0.62 1.24e-68 Smoking behavior; BRCA trans rs9858542 0.953 rs34363169 chr3:49537712 G/A cg21659725 chr3:3221576 CRBN -0.47 -9.99 -0.37 6.41e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2832191 0.716 rs9983051 chr21:30371890 C/T cg24692254 chr21:30365293 RNF160 0.79 22.07 0.66 1.09e-80 Dental caries; BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00149659 chr3:10157352 C3orf10 0.78 13.92 0.48 1.16e-38 Alzheimer's disease; BRCA cis rs875971 0.964 rs778708 chr7:65856319 T/C cg11764359 chr7:65958608 NA 0.8 19.65 0.61 1.36e-67 Aortic root size; BRCA cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -9.86 -0.36 1.87e-21 Response to bleomycin (chromatid breaks); BRCA cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg12935359 chr14:103987150 CKB 0.53 13.03 0.46 1.4e-34 Intelligence (multi-trait analysis); BRCA cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg18451016 chr1:38461880 NA 0.41 8.31 0.31 5.62e-16 Coronary artery disease; BRCA cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg22496339 chr2:162101262 NA 0.58 13.14 0.46 4.44e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA trans rs60843830 0.964 rs62114538 chr2:256116 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.59 13.32 0.47 6.92e-36 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs72781680 0.898 rs72780123 chr2:23996009 G/A cg08917208 chr2:24149416 ATAD2B 0.9 12.95 0.46 3.2e-34 Lymphocyte counts; BRCA cis rs8038465 0.662 rs7497012 chr15:73968719 G/A cg15420318 chr15:73925796 NPTN 0.38 8.24 0.31 9.56e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg22875332 chr1:76189707 ACADM 0.6 11.02 0.4 5.56e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs875971 0.862 rs10282433 chr7:65721439 G/A cg18876405 chr7:65276391 NA -0.51 -11.63 -0.42 1.78e-28 Aortic root size; BRCA cis rs60871478 1.000 rs62432861 chr7:807649 G/A cg27478167 chr7:817139 HEATR2 -0.42 -9.05 -0.34 1.73e-18 Cerebrospinal P-tau181p levels; BRCA cis rs13064411 0.696 rs6768979 chr3:113204149 G/A cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2860975 0.501 rs602941 chr10:96961184 G/A cg09036531 chr10:96991505 NA -0.66 -15.45 -0.52 5.34e-46 Immune response to smallpox vaccine (IL-6); BRCA cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.77 0.67 1.63e-84 Chronic sinus infection; BRCA trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg06636001 chr8:8085503 FLJ10661 0.48 10.43 0.38 1.21e-23 Neuroticism; BRCA cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg10932868 chr11:921992 NA 0.49 12.4 0.44 8.43e-32 Alzheimer's disease (late onset); BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -11.94 -0.43 8.33e-30 Tonsillectomy; BRCA cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.61 12.69 0.45 4.45e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs1322639 0.657 rs9355135 chr6:169573006 C/T cg03254818 chr6:169586852 NA 0.48 7.98 0.3 6.77e-15 Pulse pressure; BRCA cis rs6752107 1.000 rs2241879 chr2:234183468 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.6 0.42 2.29e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs654950 0.806 rs1535505 chr1:42026152 A/G cg06885757 chr1:42089581 HIVEP3 0.27 9.11 0.34 1.06e-18 Airway imaging phenotypes; BRCA cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg11764359 chr7:65958608 NA 0.65 11.91 0.43 1.1e-29 Aortic root size; BRCA cis rs6456156 0.586 rs7762156 chr6:167485831 A/T cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.64 0.39 1.9e-24 Motion sickness; BRCA cis rs11690935 0.550 rs11676438 chr2:172826668 G/A cg13550731 chr2:172543902 DYNC1I2 0.51 12.39 0.44 9.29e-32 Schizophrenia; BRCA cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.22 0.46 1.97e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg16680214 chr1:154839983 KCNN3 -0.43 -11.66 -0.42 1.28e-28 Prostate cancer; BRCA cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg02297831 chr4:17616191 MED28 0.36 8.46 0.32 1.75e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7615952 0.576 rs4646763 chr3:125822129 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -10.85 -0.39 2.79e-25 Blood pressure (smoking interaction); BRCA cis rs2243480 0.711 rs2420172 chr7:65635341 T/C cg18252515 chr7:66147081 NA 1.04 15.68 0.53 3.89e-47 Diabetic kidney disease; BRCA cis rs1577917 0.655 rs9444352 chr6:86257535 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.39 11.03 0.4 5.21e-26 Response to antipsychotic treatment; BRCA cis rs172166 0.694 rs203892 chr6:28067196 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.91 0.3 1.16e-14 Cardiac Troponin-T levels; BRCA cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.5 10.92 0.4 1.47e-25 Cognitive ability; BRCA cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.19 0.31 1.45e-15 Aortic root size; BRCA cis rs1348850 0.651 rs1901826 chr2:178225266 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.4 8.41 0.32 2.66e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg11843238 chr5:131593191 PDLIM4 0.35 7.93 0.3 1.01e-14 Breast cancer; BRCA cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26314531 chr2:26401878 FAM59B 0.9 16.17 0.54 1.47e-49 Gut microbiome composition (summer); BRCA cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg19539972 chr4:7069911 GRPEL1 0.69 16.91 0.56 2.59e-53 Monocyte percentage of white cells; BRCA cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.6 13.36 0.47 4.47e-36 Colorectal cancer; BRCA cis rs13046373 0.505 rs2832962 chr21:32008332 T/C cg22337977 chr21:31811175 KRTAP15-1 0.33 7.9 0.3 1.25e-14 HDL cholesterol; BRCA cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg04455712 chr21:45112962 RRP1B 0.42 11.06 0.4 3.72e-26 Mean corpuscular volume; BRCA cis rs736408 0.522 rs6445535 chr3:52771468 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.85 0.45 8.83e-34 Bipolar disorder; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg03923535 chr7:1197113 ZFAND2A 0.52 11.25 0.41 6.61e-27 Longevity;Endometriosis; BRCA cis rs11583043 0.874 rs6577219 chr1:101415707 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.47 9.62 0.36 1.45e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs3818285 0.610 rs642938 chr10:111633025 A/C cg00817464 chr10:111662876 XPNPEP1 0.45 14.74 0.5 1.53e-42 Superior crus of antihelix expression; BRCA cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg06453172 chr10:134556979 INPP5A -0.59 -11.68 -0.42 1.07e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2797160 1.000 rs9401843 chr6:126004124 T/C cg05901451 chr6:126070800 HEY2 -0.39 -9.42 -0.35 7.86e-20 Endometrial cancer; BRCA cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.83 0.39 3.19e-25 Bipolar disorder; BRCA cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg09184832 chr6:79620586 NA -0.51 -11.12 -0.4 2.32e-26 Intelligence (multi-trait analysis); BRCA trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg15704280 chr7:45808275 SEPT13 0.7 14.28 0.49 2.29e-40 Coronary artery disease; BRCA trans rs6479891 0.915 rs10740110 chr10:65043221 A/G cg14819942 chr15:35414228 NA -0.32 -8.33 -0.31 5.08e-16 Arthritis (juvenile idiopathic); BRCA cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg10932868 chr11:921992 NA -0.41 -10.12 -0.37 2.01e-22 Alzheimer's disease (late onset); BRCA cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg02743256 chr7:2109353 MAD1L1 -0.43 -8.19 -0.31 1.43e-15 Bipolar disorder; BRCA cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg17691542 chr6:26056736 HIST1H1C 0.55 11.51 0.41 5.19e-28 Height; BRCA cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg08085267 chr17:45401833 C17orf57 0.62 13.23 0.46 1.81e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.71 -0.36 7.18e-21 Body mass index; BRCA cis rs11025559 0.773 rs16906274 chr11:20470142 T/C cg19653624 chr11:20408972 PRMT3 -0.45 -10.4 -0.38 1.61e-23 Pursuit maintenance gain; BRCA cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg04450456 chr4:17643702 FAM184B 0.35 9.68 0.36 8.79e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs1215050 0.791 rs2865943 chr4:98778449 C/T cg05340658 chr4:99064831 C4orf37 0.42 9.14 0.34 8.22e-19 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs870825 0.616 rs36022027 chr4:185639192 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.27 0.56 3.85e-55 Blood protein levels; BRCA cis rs523522 0.962 rs603574 chr12:120998443 A/G cg12219531 chr12:120966889 COQ5 0.54 11.46 0.41 8.87e-28 High light scatter reticulocyte count; BRCA cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.62 0.32 5.39e-17 Personality dimensions; BRCA cis rs7927771 0.832 rs67116452 chr11:47385194 G/A cg20307385 chr11:47447363 PSMC3 -0.41 -8.68 -0.32 3.32e-17 Subjective well-being; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg04944784 chr2:26401820 FAM59B 0.99 16.67 0.55 4.37e-52 Gut microbiome composition (summer); BRCA cis rs8180040 0.966 rs2062278 chr3:47416761 C/T cg16586182 chr3:47516702 SCAP -0.63 -14.71 -0.5 2.23e-42 Colorectal cancer; BRCA cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.3 -0.35 2.28e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg17143192 chr8:8559678 CLDN23 0.55 10.42 0.38 1.33e-23 Obesity-related traits; BRCA cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.62 -15.45 -0.52 5.41e-46 Multiple sclerosis; BRCA cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg23029597 chr12:123009494 RSRC2 -0.62 -11.96 -0.43 6.82e-30 Body mass index; BRCA cis rs2882667 0.587 rs288015 chr5:138195217 T/C cg04439458 chr5:138467593 SIL1 0.31 7.96 0.3 7.72e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs9291683 0.588 rs3756236 chr4:10013463 T/A cg26043149 chr18:55253948 FECH 0.39 8.34 0.31 4.61e-16 Bone mineral density; BRCA trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg25482853 chr8:67687455 SGK3 1.05 16.94 0.56 1.94e-53 Lung disease severity in cystic fibrosis; BRCA cis rs10501293 1.000 rs12222341 chr11:43126722 T/G cg03447554 chr11:43094025 NA -0.47 -8.54 -0.32 9.91e-17 Cognitive performance; BRCA cis rs367615 0.918 rs10054960 chr5:108866448 C/A cg17395555 chr5:108820864 NA 0.38 9.75 0.36 4.83e-21 Colorectal cancer (SNP x SNP interaction); BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg03188948 chr7:1209495 NA 0.86 11.78 0.42 3.91e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7927771 0.524 rs10838775 chr11:47856382 C/G cg20307385 chr11:47447363 PSMC3 0.42 9.49 0.35 4.34e-20 Subjective well-being; BRCA cis rs4689388 0.853 rs13114527 chr4:6294655 T/G cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs8180040 0.627 rs9821119 chr3:47198437 C/G cg27129171 chr3:47204927 SETD2 0.72 17.52 0.57 2.13e-56 Colorectal cancer; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -13.4 -0.47 2.92e-36 Bipolar disorder and schizophrenia; BRCA cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg15395560 chr15:45543142 SLC28A2 -0.29 -7.83 -0.3 2.02e-14 Uric acid levels; BRCA cis rs17095355 1.000 rs17126931 chr10:111754633 T/C cg00817464 chr10:111662876 XPNPEP1 -0.44 -9.41 -0.35 9.12e-20 Biliary atresia; BRCA cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg06484146 chr7:12443880 VWDE -0.75 -10.68 -0.39 1.35e-24 Coronary artery disease; BRCA trans rs7395662 0.824 rs4882180 chr11:48749357 C/A cg00717180 chr2:96193071 NA -0.28 -7.86 -0.3 1.68e-14 HDL cholesterol; BRCA cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg06550200 chr5:1325588 CLPTM1L -0.64 -13.45 -0.47 1.74e-36 Lung cancer; BRCA cis rs6594713 0.717 rs13174075 chr5:112795352 A/T cg12552261 chr5:112820674 MCC 0.47 8.01 0.3 5.52e-15 Brain cytoarchitecture; BRCA cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg16680214 chr1:154839983 KCNN3 -0.45 -12.5 -0.44 3.03e-32 Prostate cancer; BRCA cis rs7927771 0.524 rs10838740 chr11:47679980 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.43e-20 Subjective well-being; BRCA cis rs73086581 1.000 rs73086540 chr20:3950850 T/C cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs796364 1.000 rs281771 chr2:200812202 A/C cg23649088 chr2:200775458 C2orf69 -0.59 -8.81 -0.33 1.21e-17 Schizophrenia; BRCA cis rs9463078 0.656 rs227838 chr6:44684621 C/A cg25276700 chr6:44698697 NA 0.38 8.53 0.32 1.1e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs523522 0.962 rs4766968 chr12:120947788 G/C cg12219531 chr12:120966889 COQ5 0.55 11.49 0.41 6.69e-28 High light scatter reticulocyte count; BRCA cis rs7103648 0.545 rs6485795 chr11:47929846 G/A cg20307385 chr11:47447363 PSMC3 0.7 15.55 0.52 1.81e-46 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1371614 0.550 rs2384508 chr2:27143056 T/A cg12368169 chr2:27073192 DPYSL5 0.28 8.24 0.31 1e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg03923535 chr7:1197113 ZFAND2A 0.4 7.89 0.3 1.31e-14 Longevity;Endometriosis; BRCA cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg19901468 chr14:105411992 AHNAK2 -0.49 -12.02 -0.43 3.73e-30 Rheumatoid arthritis; BRCA cis rs870825 0.549 rs28542773 chr4:185617935 A/G cg04058563 chr4:185651563 MLF1IP 0.78 17.28 0.56 3.69e-55 Blood protein levels; BRCA cis rs11702148 0.552 rs6517178 chr21:34888621 C/T cg14850771 chr21:34775459 IFNGR2 -0.37 -8.1 -0.31 2.76e-15 Mean corpuscular hemoglobin; BRCA cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg15704280 chr7:45808275 SEPT13 0.71 14.36 0.49 9.81e-41 Coronary artery disease; BRCA cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.49 9.71 0.36 7.07e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6942756 0.680 rs691555 chr7:129135770 C/T cg02491457 chr7:128862824 NA -0.52 -10.92 -0.4 1.41e-25 White matter hyperintensity burden; BRCA cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg22974920 chr21:40686053 BRWD1 -0.35 -7.85 -0.3 1.81e-14 Menarche (age at onset); BRCA trans rs6952808 0.723 rs55689856 chr7:2037215 G/A cg04565464 chr8:145669602 NFKBIL2 0.37 8.69 0.33 2.93e-17 Bipolar disorder and schizophrenia; BRCA cis rs1011018 0.628 rs740818 chr7:139452390 C/T cg03224163 chr7:139420300 HIPK2 -0.59 -8.91 -0.33 5.15e-18 Systolic blood pressure; BRCA cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.49 0.38 7.36e-24 Motion sickness; BRCA cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg21724239 chr8:58056113 NA 0.46 8.08 0.3 3.13e-15 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.08 0.64 2.75e-75 Gut microbiome composition (summer); BRCA cis rs1891275 0.515 rs1080496 chr10:93444262 C/T cg07889827 chr10:93443413 NA 0.43 12.24 0.44 4.36e-31 Intelligence (multi-trait analysis); BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg18538332 chr22:24372958 LOC391322 0.55 13.5 0.47 1.02e-36 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.69e-52 Extrinsic epigenetic age acceleration; BRCA cis rs273218 1.000 rs274366 chr5:53374636 C/G ch.5.1024479R chr5:53302184 ARL15 0.42 8.68 0.32 3.31e-17 Migraine; BRCA cis rs10080237 0.564 rs2490232 chr6:80814802 C/T cg08355045 chr6:80787529 NA -0.41 -10.7 -0.39 1.11e-24 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; BRCA cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg02187348 chr16:89574699 SPG7 0.5 11.69 0.42 9.21e-29 Multiple myeloma (IgH translocation); BRCA cis rs897984 0.645 rs9938550 chr16:30999142 A/G cg00531865 chr16:30841666 NA 0.4 9.39 0.35 1.03e-19 Dementia with Lewy bodies; BRCA cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg08999081 chr20:33150536 PIGU 0.5 14.21 0.49 5.31e-40 Coronary artery disease; BRCA cis rs11764590 0.694 rs11773643 chr7:2104063 A/G cg23422044 chr7:1970798 MAD1L1 -0.41 -8.71 -0.33 2.68e-17 Neuroticism; BRCA cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.92 20.79 0.64 9.64e-74 Smoking behavior; BRCA cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs8077889 0.956 rs17742347 chr17:41846468 A/G cg26893861 chr17:41843967 DUSP3 -0.87 -15.62 -0.53 7.89e-47 Triglycerides; BRCA cis rs708547 0.581 rs781661 chr4:57780307 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.34 -8.54 -0.32 9.91e-17 Response to bleomycin (chromatid breaks); BRCA cis rs36051895 0.664 rs3780381 chr9:5114523 A/C cg02405213 chr9:5042618 JAK2 -0.5 -9.03 -0.34 2.02e-18 Pediatric autoimmune diseases; BRCA trans rs11098499 0.863 rs12502389 chr4:120454191 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg13271783 chr10:134563150 INPP5A -0.48 -9.24 -0.34 3.54e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg03213289 chr20:61660250 NA 0.61 15.95 0.53 1.82e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs17685 0.753 rs13240967 chr7:75658197 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.39 8.77 0.33 1.66e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1018836 0.886 rs4734246 chr8:91569028 A/C cg16814680 chr8:91681699 NA -0.64 -14.25 -0.49 3.37e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg26384229 chr12:38710491 ALG10B 0.84 22.67 0.67 5.83e-84 Heart rate; BRCA cis rs11105298 0.891 rs11105287 chr12:89829470 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.47 -8.32 -0.31 5.48e-16 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs11098499 0.697 rs28458294 chr4:120238924 T/C cg09307838 chr4:120376055 NA 0.63 13.59 0.47 3.72e-37 Corneal astigmatism; BRCA cis rs67460515 0.892 rs11929238 chr3:161045937 A/T cg03342759 chr3:160939853 NMD3 -0.81 -19.0 -0.6 3.77e-64 Parkinson's disease; BRCA cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg14349672 chr11:133703707 NA -0.4 -8.99 -0.33 2.84e-18 Childhood ear infection; BRCA cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg00750074 chr16:89608354 SPG7 -0.35 -8.46 -0.32 1.79e-16 Multiple myeloma (IgH translocation); BRCA cis rs1691799 0.899 rs1168300 chr12:66736467 C/A cg16791601 chr12:66731901 HELB -0.64 -17.29 -0.56 3.01e-55 White blood cell count (basophil); BRCA cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08219700 chr8:58056026 NA 0.64 15.16 0.51 1.48e-44 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.721 rs10890336 chr1:46111056 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg12564285 chr5:131593104 PDLIM4 0.38 10.38 0.38 1.93e-23 Breast cancer; BRCA cis rs2594714 0.515 rs10411270 chr19:13940838 A/T cg18576835 chr19:13944261 NA -0.37 -10.04 -0.37 4.14e-22 Breast cancer; BRCA cis rs8072100 0.967 rs8074149 chr17:45583375 A/C cg08085267 chr17:45401833 C17orf57 0.57 11.98 0.43 5.64e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs739401 0.611 rs401707 chr11:3050965 T/C cg08508325 chr11:3079039 CARS -0.43 -15.65 -0.53 5.49e-47 Longevity; BRCA cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg11764359 chr7:65958608 NA -0.62 -13.14 -0.46 4.35e-35 Aortic root size; BRCA cis rs2046867 0.818 rs62249863 chr3:72868666 G/C cg25664220 chr3:72788482 NA -0.55 -11.68 -0.42 1.03e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs7617773 0.817 rs6794644 chr3:48330037 T/C cg11946769 chr3:48343235 NME6 0.63 13.53 0.47 7.1e-37 Coronary artery disease; BRCA cis rs17685 0.753 rs55812043 chr7:75747241 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.76 -0.36 4.52e-21 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg21573476 chr21:45109991 RRP1B -0.38 -9.74 -0.36 5.23e-21 Mean corpuscular volume; BRCA cis rs2425143 1.000 rs2425078 chr20:34298163 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.14 -0.37 1.7e-22 Blood protein levels; BRCA cis rs7264396 0.580 rs2425173 chr20:34445142 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -12.04 -0.43 3.17e-30 Total cholesterol levels; BRCA cis rs881375 0.702 rs3761847 chr9:123690239 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 11.03 0.4 5.01e-26 Rheumatoid arthritis; BRCA cis rs208520 0.690 rs12189780 chr6:66759619 G/A cg07460842 chr6:66804631 NA 1.0 19.85 0.62 1.2e-68 Exhaled nitric oxide output; BRCA trans rs1493916 1.000 rs990882 chr18:31398180 T/G cg27147174 chr7:100797783 AP1S1 -0.55 -11.05 -0.4 4.11e-26 Life satisfaction; BRCA cis rs36051895 0.658 rs10974912 chr9:5010885 A/C cg02405213 chr9:5042618 JAK2 -0.53 -9.17 -0.34 6.52e-19 Pediatric autoimmune diseases; BRCA cis rs9325144 0.554 rs1906264 chr12:38739490 A/G cg26384229 chr12:38710491 ALG10B 0.48 12.36 0.44 1.27e-31 Morning vs. evening chronotype; BRCA cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.15 -0.4 1.74e-26 Schizophrenia; BRCA cis rs11190604 1.000 rs11190555 chr10:102209160 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.33 0.41 2.98e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs17092148 0.943 rs4911160 chr20:33349940 G/A cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg06808227 chr14:105710500 BRF1 -0.79 -16.38 -0.54 1.26e-50 Mean platelet volume;Platelet distribution width; BRCA trans rs1459104 1.000 rs12789864 chr11:55197211 A/C cg15704280 chr7:45808275 SEPT13 -0.66 -8.27 -0.31 7.57e-16 Body mass index; BRCA cis rs9399135 0.967 rs7741515 chr6:135374368 C/G cg24558204 chr6:135376177 HBS1L -0.46 -12.53 -0.44 2.38e-32 Red blood cell count; BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg25036284 chr2:26402008 FAM59B 0.95 16.07 0.54 4.82e-49 Gut microbiome composition (summer); BRCA cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg02527881 chr3:46936655 PTH1R 0.35 8.2 0.31 1.35e-15 Birth weight; BRCA cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg25319279 chr11:5960081 NA -0.43 -8.37 -0.31 3.51e-16 DNA methylation (variation); BRCA cis rs12464559 0.649 rs4664496 chr2:152522556 T/C cg01189475 chr2:152685088 ARL5A -0.51 -7.88 -0.3 1.38e-14 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg27398817 chr8:82754497 SNX16 -0.35 -8.02 -0.3 5.06e-15 Diastolic blood pressure; BRCA cis rs16976116 0.901 rs2899582 chr15:55491734 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.57 0.39 3.49e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.67e-50 Alzheimer's disease (late onset); BRCA cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg22875332 chr1:76189707 ACADM 0.64 11.95 0.43 7.2e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2421770 0.530 rs2421764 chr11:35364578 A/T cg13971030 chr11:35366721 SLC1A2 -0.45 -10.12 -0.37 2.02e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg10932868 chr11:921992 NA 0.5 12.88 0.45 6.41e-34 Alzheimer's disease (late onset); BRCA cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg05835009 chr4:710272 PCGF3 0.47 10.45 0.38 1.02e-23 White blood cell count; BRCA trans rs8002861 0.664 rs9533686 chr13:44468494 A/G cg17145862 chr1:211918768 LPGAT1 0.53 12.0 0.43 4.61e-30 Leprosy; BRCA cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg12310025 chr6:25882481 NA 0.74 17.89 0.58 2.58e-58 Blood metabolite levels; BRCA cis rs1801251 0.727 rs283482 chr2:233646920 A/T cg25237894 chr2:233734115 C2orf82 0.32 9.11 0.34 1.08e-18 Coronary artery disease; BRCA cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg25319279 chr11:5960081 NA -0.43 -8.4 -0.32 2.92e-16 DNA methylation (variation); BRCA trans rs4596713 0.507 rs2275427 chr9:71792581 G/A cg16512924 chr15:28394682 HERC2 0.45 10.8 0.39 4.51e-25 Headache; BRCA cis rs7953249 1.000 rs7953249 chr12:121403724 A/G cg02403541 chr12:121454288 C12orf43 0.4 8.34 0.31 4.67e-16 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs503734 0.502 rs513154 chr3:100953212 T/G cg27318481 chr3:100970896 IMPG2 -0.35 -8.32 -0.31 5.34e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg26384229 chr12:38710491 ALG10B 0.72 17.02 0.56 7.11e-54 Drug-induced liver injury (flucloxacillin); BRCA trans rs6479891 1.000 rs16918575 chr10:65301325 C/T cg14819942 chr15:35414228 NA -0.34 -8.25 -0.31 9.01e-16 Arthritis (juvenile idiopathic); BRCA cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.07e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7098414 0.511 rs10466236 chr10:82149717 C/T cg01528321 chr10:82214614 TSPAN14 -0.68 -14.76 -0.5 1.26e-42 Post bronchodilator FEV1; BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.59 -10.01 -0.37 5.33e-22 Gut microbiome composition (summer); BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.87 -18.92 -0.6 9.8e-64 Gut microbiome composition (summer); BRCA cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg17971929 chr21:40555470 PSMG1 -0.62 -14.35 -0.49 1.1e-40 Cognitive function; BRCA cis rs56104184 0.830 rs17272658 chr19:49355405 C/T cg15549821 chr19:49342101 PLEKHA4 -1.05 -15.64 -0.53 6.17e-47 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs11039798 1.000 rs7104642 chr11:48588534 C/T cg15704280 chr7:45808275 SEPT13 0.54 8.11 0.31 2.55e-15 Axial length; BRCA cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 13.93 0.48 1.01e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs739401 0.611 rs2071104 chr11:3036933 G/T cg25174290 chr11:3078921 CARS 0.44 13.56 0.47 5.29e-37 Longevity; BRCA cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg12564285 chr5:131593104 PDLIM4 -0.34 -7.97 -0.3 7.56e-15 Breast cancer; BRCA cis rs60843830 0.508 rs300750 chr2:208794 T/G cg25945732 chr2:264204 ACP1;SH3YL1 0.45 9.61 0.36 1.63e-20 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2370759 1.000 rs78959390 chr10:32616346 C/T cg18270830 chr10:32634957 EPC1 0.6 10.44 0.38 1.1e-23 Sexual dysfunction (female); BRCA cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg08917208 chr2:24149416 ATAD2B 0.55 8.53 0.32 1.1e-16 Lymphocyte counts; BRCA cis rs7552404 1.000 rs211723 chr1:76103030 C/T cg03433033 chr1:76189801 ACADM -0.71 -15.89 -0.53 3.49e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg03709012 chr19:19516395 GATAD2A 0.81 18.74 0.6 9.07e-63 Tonsillectomy; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg14820908 chr5:178986412 RUFY1 -0.46 -12.32 -0.44 1.9e-31 Lung cancer; BRCA cis rs7267979 0.714 rs3787082 chr20:25235736 A/T cg08601574 chr20:25228251 PYGB 0.34 8.02 0.3 5.08e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.71 -12.18 -0.43 7.73e-31 Platelet count; BRCA cis rs7127900 0.583 rs11043140 chr11:2233951 T/C cg12428727 chr11:2234665 NA 0.54 13.2 0.46 2.34e-35 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); BRCA trans rs3733585 0.699 rs6449176 chr4:9967843 G/A cg26043149 chr18:55253948 FECH -0.38 -8.34 -0.31 4.43e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1003719 0.715 rs2212742 chr21:38578685 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs6582630 0.512 rs11181007 chr12:38266700 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.04 -0.37 4.08e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7523050 0.730 rs34254854 chr1:109419875 C/T cg08274380 chr1:109419600 GPSM2 1.18 16.6 0.55 1.05e-51 Fat distribution (HIV); BRCA cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -9.61 -0.36 1.59e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.954 rs4577559 chr4:120404043 T/G cg09307838 chr4:120376055 NA 0.72 15.28 0.52 3.69e-45 Corneal astigmatism; BRCA cis rs478304 0.903 rs1151502 chr11:65503485 G/C cg08755490 chr11:65554678 OVOL1 0.53 10.96 0.4 9.69e-26 Acne (severe); BRCA cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg11764359 chr7:65958608 NA -0.79 -19.23 -0.61 2.32e-65 Aortic root size; BRCA cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg18876405 chr7:65276391 NA -0.51 -11.69 -0.42 9.89e-29 Aortic root size; BRCA cis rs897984 0.762 rs8062719 chr16:31002664 A/G cg00531865 chr16:30841666 NA 0.35 7.93 0.3 1.01e-14 Dementia with Lewy bodies; BRCA cis rs9503598 0.636 rs6596976 chr6:3466022 C/T cg00476032 chr6:3446245 SLC22A23 0.36 8.88 0.33 6.94e-18 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs10242455 0.557 rs77997620 chr7:99070415 G/T cg18809830 chr7:99032528 PTCD1 -0.62 -8.67 -0.32 3.57e-17 Blood metabolite levels; BRCA cis rs1904096 0.506 rs28522293 chr4:95167087 A/G cg11021082 chr4:95130006 SMARCAD1 -0.43 -9.85 -0.36 2.06e-21 Type 2 diabetes; BRCA trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.54 17.14 0.56 1.76e-54 Intelligence (multi-trait analysis); BRCA trans rs208520 0.690 rs3843513 chr6:66836797 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.94 -0.64 1.49e-74 Exhaled nitric oxide output; BRCA cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg26818010 chr10:134567672 INPP5A -0.77 -15.57 -0.52 1.4e-46 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3768617 0.510 rs12095664 chr1:183101686 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg24692254 chr21:30365293 RNF160 0.78 21.21 0.64 5.62e-76 Dental caries; BRCA cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.25 0.38 6.57e-23 Bladder cancer; BRCA cis rs1003719 0.715 rs8128387 chr21:38556787 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.54 -0.5 1.43e-41 Eye color traits; BRCA cis rs2302729 0.578 rs11062298 chr12:2771709 A/C cg19945202 chr12:2788847 CACNA1C -0.44 -9.71 -0.36 6.78e-21 Sleep quality; BRCA cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg07308232 chr7:1071921 C7orf50 -0.45 -9.37 -0.35 1.27e-19 Longevity;Endometriosis; BRCA cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14442939 chr10:27389572 ANKRD26 0.7 11.0 0.4 6.54e-26 Breast cancer; BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA trans rs61931739 0.534 rs1705757 chr12:34091637 A/G cg26384229 chr12:38710491 ALG10B 0.56 12.1 0.43 1.69e-30 Morning vs. evening chronotype; BRCA cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg08999081 chr20:33150536 PIGU -0.44 -12.13 -0.43 1.31e-30 Glomerular filtration rate (creatinine); BRCA cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg23719950 chr11:63933701 MACROD1 -0.57 -9.5 -0.35 4.3e-20 Mean platelet volume; BRCA cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg17063962 chr7:91808500 NA 0.53 12.53 0.44 2.32e-32 Breast cancer; BRCA cis rs7904368 0.754 rs12269366 chr10:16850344 G/A cg23933602 chr10:16859644 RSU1 0.59 9.02 0.34 2.13e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs910316 0.712 rs175037 chr14:75465038 T/C cg08847533 chr14:75593920 NEK9 -0.84 -20.9 -0.64 2.57e-74 Height; BRCA cis rs7246657 0.941 rs10418729 chr19:37737065 A/C cg23950597 chr19:37808831 NA -0.7 -12.08 -0.43 2.13e-30 Coronary artery calcification; BRCA trans rs6089829 1.000 rs62207535 chr20:61669187 A/G cg17470723 chr8:74884337 TCEB1 0.44 9.14 0.34 8.44e-19 Prostate cancer (SNP x SNP interaction); BRCA cis rs919433 0.679 rs13394214 chr2:198527371 C/T cg00792783 chr2:198669748 PLCL1 0.41 9.04 0.34 1.83e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6545883 0.899 rs12473030 chr2:61720497 T/A cg15711740 chr2:61764176 XPO1 -0.55 -13.96 -0.48 7.18e-39 Tuberculosis; BRCA cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg08392591 chr16:89556376 ANKRD11 0.52 12.54 0.44 1.99e-32 Multiple myeloma (IgH translocation); BRCA trans rs61931739 0.500 rs6488211 chr12:34375620 A/T cg26384229 chr12:38710491 ALG10B -0.64 -14.13 -0.49 1.24e-39 Morning vs. evening chronotype; BRCA cis rs17601876 1.000 rs17601876 chr15:51553909 C/T cg19946085 chr15:51559439 CYP19A1 0.31 8.59 0.32 6.58e-17 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg06271696 chr7:157225062 NA -0.39 -10.37 -0.38 2.18e-23 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg06784218 chr1:46089804 CCDC17 -0.49 -11.81 -0.42 3.11e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.54 -10.97 -0.4 8.59e-26 Lymphocyte counts; BRCA cis rs7131987 0.718 rs7976961 chr12:29463088 C/T cg09582351 chr12:29534625 ERGIC2 -0.46 -10.63 -0.39 1.99e-24 QT interval; BRCA cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.69 18.98 0.6 4.85e-64 Electrocardiographic conduction measures; BRCA cis rs1113500 0.933 rs10881498 chr1:108634984 C/A cg06207961 chr1:108661230 NA 0.46 11.28 0.41 4.71e-27 Growth-regulated protein alpha levels; BRCA cis rs6964587 0.839 rs17731846 chr7:91440342 A/G cg17063962 chr7:91808500 NA 0.51 11.31 0.41 3.6e-27 Breast cancer; BRCA cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.08 -0.3 3.18e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg07606381 chr6:8435919 SLC35B3 0.64 14.2 0.49 5.86e-40 Motion sickness; BRCA cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.07 -0.46 9.15e-35 Chronic sinus infection; BRCA cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg02297831 chr4:17616191 MED28 0.37 8.61 0.32 5.47e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4478858 0.698 rs7543348 chr1:31804805 A/C cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs4494114 0.875 rs7518432 chr1:39363522 G/C cg25970120 chr1:39325951 RRAGC -0.37 -7.84 -0.3 1.84e-14 Blood protein levels; BRCA cis rs9291683 0.567 rs12499857 chr4:9995376 G/A cg02734326 chr4:10020555 SLC2A9 0.39 8.59 0.32 6.4e-17 Bone mineral density; BRCA cis rs7246657 0.550 rs9941475 chr19:38064517 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 14.0 0.48 5.06e-39 Personality dimensions; BRCA cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg20476274 chr7:133979776 SLC35B4 0.56 14.19 0.49 6.48e-40 Mean platelet volume; BRCA cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg12463550 chr7:65579703 CRCP -0.38 -8.21 -0.31 1.26e-15 Aortic root size; BRCA cis rs9831754 0.704 rs1512491 chr3:78470954 T/C cg06138941 chr3:78371609 NA 0.52 11.52 0.41 4.78e-28 Calcium levels; BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg01262667 chr19:19385393 TM6SF2 -0.38 -9.7 -0.36 7.6e-21 Tonsillectomy; BRCA cis rs1580019 0.922 rs1376289 chr7:32486980 C/G cg07520158 chr7:32535189 LSM5;AVL9 -0.42 -8.72 -0.33 2.33e-17 Cognitive ability; BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg10729496 chr3:10149963 C3orf24 0.48 8.94 0.33 4.05e-18 Alzheimer's disease; BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -9.05 -0.34 1.75e-18 Tonsillectomy; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg25036284 chr2:26402008 FAM59B -0.93 -15.85 -0.53 5.8e-48 Gut microbiome composition (summer); BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg18402987 chr7:1209562 NA 0.84 12.05 0.43 2.8e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088813 1.000 rs6088799 chr20:33934301 T/C cg14752227 chr20:34000481 UQCC -0.41 -8.74 -0.33 2.11e-17 Height; BRCA cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg25173405 chr17:45401733 C17orf57 -0.57 -12.29 -0.44 2.69e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9649465 0.846 rs13044 chr7:123322716 T/A cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs9291683 0.588 rs3733586 chr4:9997534 C/T cg00071950 chr4:10020882 SLC2A9 0.6 15.02 0.51 6.86e-44 Bone mineral density; BRCA cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.84 -0.3 1.86e-14 Aortic root size; BRCA cis rs7772486 0.875 rs2328712 chr6:146344563 T/C cg23711669 chr6:146136114 FBXO30 0.64 14.59 0.5 8.38e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070997 0.607 rs13294646 chr9:133715206 C/G cg11464064 chr9:133710261 ABL1 0.55 9.99 0.37 6.09e-22 Response to amphetamines; BRCA trans rs12310956 0.532 rs11052920 chr12:33955891 T/G cg26384229 chr12:38710491 ALG10B 0.46 10.25 0.38 6.32e-23 Morning vs. evening chronotype; BRCA cis rs72781680 0.898 rs12619525 chr2:23999565 G/C cg08917208 chr2:24149416 ATAD2B 0.9 12.95 0.46 3.2e-34 Lymphocyte counts; BRCA cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs3760982 0.585 rs11673490 chr19:44298885 C/A cg11993925 chr19:44307056 LYPD5 0.38 8.98 0.33 3e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.74 15.44 0.52 6.27e-46 Smoking behavior; BRCA cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg24549020 chr5:56110836 MAP3K1 0.58 11.71 0.42 7.8e-29 Initial pursuit acceleration; BRCA cis rs6714710 0.603 rs11692010 chr2:98397301 C/T cg26665480 chr2:98280029 ACTR1B 0.58 13.53 0.47 7.02e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7772486 0.875 rs6909827 chr6:146365738 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.76 0.5 1.21e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs10927875 0.541 rs1763599 chr1:16342602 C/T cg06159980 chr1:16340746 HSPB7 -0.38 -8.83 -0.33 1.04e-17 Dilated cardiomyopathy; BRCA cis rs3008870 1.000 rs4655663 chr1:67430103 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.02 22.6 0.67 1.46e-83 Lymphocyte percentage of white cells; BRCA cis rs6973256 0.865 rs2909225 chr7:133331952 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.8 -0.33 1.26e-17 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg20701182 chr2:24300061 SF3B14 0.66 9.71 0.36 6.96e-21 Lymphocyte counts; BRCA cis rs11098499 0.954 rs12506546 chr4:120301618 T/C cg09307838 chr4:120376055 NA 0.71 15.0 0.51 8.2e-44 Corneal astigmatism; BRCA cis rs12579753 0.879 rs7131927 chr12:82166313 T/C cg07988820 chr12:82153109 PPFIA2 -0.65 -10.97 -0.4 8.6e-26 Resting heart rate; BRCA cis rs929596 0.755 rs4148325 chr2:234673309 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.43 -10.91 -0.4 1.57e-25 Total bilirubin levels in HIV-1 infection; BRCA cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg13770153 chr20:60521292 NA 0.38 9.37 0.35 1.19e-19 Body mass index; BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg14820908 chr5:178986412 RUFY1 0.35 8.04 0.3 4.34e-15 Lung cancer; BRCA cis rs965469 0.895 rs12626130 chr20:3393192 G/T cg25506879 chr20:3388711 C20orf194 -0.52 -9.46 -0.35 5.57e-20 IFN-related cytopenia; BRCA cis rs9733 0.628 rs11807409 chr1:150683423 C/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg00631329 chr6:26305371 NA -0.44 -13.0 -0.46 1.8e-34 Educational attainment; BRCA cis rs7149337 0.805 rs2999355 chr14:51607084 A/G cg23942311 chr14:51606299 NA 0.45 13.31 0.47 7.73e-36 Cancer; BRCA cis rs6782228 0.606 rs2811490 chr3:128351755 C/T cg16766828 chr3:128327626 NA -0.43 -9.56 -0.35 2.44e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs2742234 0.590 rs2505506 chr10:43645854 C/T cg02780029 chr10:43622663 RET -0.35 -8.08 -0.3 3.2e-15 Hirschsprung disease; BRCA cis rs2762353 0.935 rs1165195 chr6:25815080 T/G cg03264133 chr6:25882463 NA -0.49 -10.97 -0.4 9.28e-26 Blood metabolite levels; BRCA cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg11822812 chr5:140052017 DND1 -0.3 -8.28 -0.31 7.25e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs3087591 1.000 rs2905877 chr17:29543269 A/C cg24425628 chr17:29625626 OMG;NF1 -0.47 -9.63 -0.36 1.39e-20 Hip circumference; BRCA cis rs7098414 0.511 rs10887828 chr10:82151470 T/C cg00277334 chr10:82204260 NA -0.49 -10.48 -0.38 8e-24 Post bronchodilator FEV1; BRCA cis rs875971 0.862 rs6962717 chr7:65883735 G/A cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs7301826 0.651 rs4514465 chr12:131313669 T/A cg11011512 chr12:131303247 STX2 0.53 13.81 0.48 3.91e-38 Plasma plasminogen activator levels; BRCA cis rs495337 0.646 rs6067267 chr20:48528237 G/A cg17835207 chr20:48524531 SPATA2 -0.68 -16.81 -0.55 9.28e-53 Psoriasis; BRCA cis rs3733585 0.673 rs7378340 chr4:9955198 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.52 -0.38 5.79e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg22972055 chr7:872293 UNC84A -0.37 -8.32 -0.31 5.42e-16 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.830 rs1456208 chr4:98678563 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.6 0.35 1.83e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs7481584 0.624 rs449164 chr11:3053454 C/T cg08508325 chr11:3079039 CARS 0.27 8.15 0.31 1.92e-15 Calcium levels; BRCA cis rs1878931 0.580 rs4578649 chr16:3407258 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.84 -20.89 -0.64 2.91e-74 Body mass index (adult); BRCA cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg11632617 chr15:75315747 PPCDC -0.38 -8.39 -0.32 3.01e-16 Blood trace element (Zn levels); BRCA cis rs9796 0.516 rs28473405 chr15:41293170 C/T cg18705301 chr15:41695430 NDUFAF1 -0.4 -8.0 -0.3 5.73e-15 Menopause (age at onset); BRCA cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg05347473 chr6:146136440 FBXO30 0.46 9.07 0.34 1.48e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg26119090 chr2:26468346 HADHA;HADHB 1.02 20.86 0.64 4.1e-74 Mean corpuscular hemoglobin; BRCA cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.85 0.45 8.78e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs30380 1.000 rs26510 chr5:96125910 C/T cg16492584 chr5:96139282 ERAP1 -0.31 -7.99 -0.3 6.4e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs950776 0.518 rs1504545 chr15:78818471 C/G cg22563815 chr15:78856949 CHRNA5 -0.38 -8.79 -0.33 1.41e-17 Sudden cardiac arrest; BRCA trans rs75804782 0.521 rs72994970 chr2:239426992 G/A cg01134436 chr17:81009848 B3GNTL1 0.7 8.78 0.33 1.5e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg11812906 chr14:75593930 NEK9 -0.69 -16.23 -0.54 7.23e-50 Height; BRCA cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg10553204 chr2:20871195 GDF7 -0.32 -8.75 -0.33 1.88e-17 Abdominal aortic aneurysm; BRCA cis rs3733585 0.673 rs6449156 chr4:9956712 G/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.49 -0.38 7.35e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs6951245 0.638 rs74976697 chr7:1160505 C/T cg13565492 chr6:43139072 SRF -0.78 -12.07 -0.43 2.34e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11165623 0.792 rs12132069 chr1:96918809 A/C cg10631902 chr5:14652156 NA -0.52 -16.97 -0.56 1.36e-53 Hip circumference;Waist circumference; BRCA trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg11707556 chr5:10655725 ANKRD33B -0.43 -9.56 -0.35 2.57e-20 Coronary artery disease; BRCA cis rs6424115 0.546 rs35993651 chr1:24180613 C/G cg10978503 chr1:24200527 CNR2 -0.52 -13.74 -0.48 8.06e-38 Immature fraction of reticulocytes; BRCA cis rs77633900 0.614 rs280024 chr15:77034518 A/C cg21673338 chr15:77095150 SCAPER -0.53 -9.67 -0.36 1.02e-20 Non-glioblastoma glioma;Glioma; BRCA cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg05025164 chr4:1340916 KIAA1530 0.4 8.69 0.33 3.01e-17 Longevity; BRCA cis rs9467773 1.000 rs1884948 chr6:26567988 G/A cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.4e-57 Intelligence (multi-trait analysis); BRCA cis rs9420 0.703 rs10896661 chr11:57679029 C/A cg19752551 chr11:57585705 CTNND1 -0.41 -8.98 -0.33 3.11e-18 Schizophrenia; BRCA cis rs7264396 0.790 rs3746410 chr20:34190870 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -11.95 -0.43 7.81e-30 Total cholesterol levels; BRCA cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg23788917 chr6:8435910 SLC35B3 0.47 10.32 0.38 3.45e-23 Motion sickness; BRCA cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg12311346 chr5:56204834 C5orf35 -0.74 -14.86 -0.51 3.96e-43 Initial pursuit acceleration; BRCA cis rs3772130 0.564 rs9817555 chr3:121406327 G/A cg20356878 chr3:121714668 ILDR1 0.38 8.6 0.32 6.17e-17 Cognitive performance; BRCA cis rs28830936 0.966 rs1107858 chr15:41968226 G/A cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.09 -0.34 1.2e-18 Diastolic blood pressure; BRCA cis rs8180040 0.966 rs62260711 chr3:47564491 G/C cg27129171 chr3:47204927 SETD2 -0.67 -14.82 -0.51 6.36e-43 Colorectal cancer; BRCA cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg20362242 chr5:692897 TPPP 0.52 8.45 0.32 1.92e-16 Lung disease severity in cystic fibrosis; BRCA cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg19318889 chr4:1322082 MAEA -0.57 -12.12 -0.43 1.47e-30 Longevity; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg03188948 chr7:1209495 NA 0.67 14.11 0.49 1.55e-39 Longevity;Endometriosis; BRCA cis rs870825 0.616 rs67641203 chr4:185623845 A/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7927771 0.832 rs55677087 chr11:47397714 C/G cg20307385 chr11:47447363 PSMC3 -0.41 -8.42 -0.32 2.46e-16 Subjective well-being; BRCA cis rs7833986 0.501 rs2953901 chr8:56981824 C/A cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.36 0.47 4.56e-36 Height; BRCA cis rs4363385 0.791 rs489323 chr1:153006047 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.57 11.04 0.4 4.77e-26 Tonsillectomy; BRCA cis rs11888559 0.573 rs7602826 chr2:203860716 G/A cg24605529 chr2:203879461 NBEAL1 0.45 8.52 0.32 1.12e-16 Height; BRCA cis rs4595586 0.545 rs7972590 chr12:39376615 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs1976403 0.633 rs1780324 chr1:21821757 A/G cg04349561 chr1:21808255 NBPF3 -0.33 -7.96 -0.3 7.63e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs41271473 0.526 rs10916339 chr1:228716894 C/T cg16512390 chr1:228756714 NA 0.57 9.08 0.34 1.39e-18 Chronic lymphocytic leukemia; BRCA cis rs10193935 0.901 rs6752455 chr2:42543577 A/C cg27598129 chr2:42591480 NA -0.91 -14.46 -0.5 3.21e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.695 rs6488939 chr12:122858250 T/C cg23029597 chr12:123009494 RSRC2 -0.43 -8.9 -0.33 5.5e-18 Body mass index; BRCA cis rs9467773 1.000 rs11756120 chr6:26529808 G/C cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg02175503 chr12:58329896 NA 0.74 15.82 0.53 8.21e-48 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.863 rs10030660 chr4:120436704 G/A cg09307838 chr4:120376055 NA 0.69 14.05 0.49 2.88e-39 Corneal astigmatism; BRCA cis rs56104184 0.615 rs73061693 chr19:49399941 C/A cg15549821 chr19:49342101 PLEKHA4 -0.67 -9.72 -0.36 6.19e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs911186 0.679 rs67330695 chr6:27103654 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -9.94 -0.37 9.58e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2580764 0.678 rs2255112 chr2:55200800 T/G cg09592903 chr2:55203963 RTN4 0.42 10.68 0.39 1.28e-24 Mean platelet volume; BRCA cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg13010199 chr12:38710504 ALG10B 0.45 9.28 0.34 2.51e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.63 -13.54 -0.47 6.76e-37 Lymphocyte counts; BRCA cis rs7647973 0.626 rs6809879 chr3:49834571 A/G cg07636037 chr3:49044803 WDR6 -0.5 -8.23 -0.31 1.03e-15 Menarche (age at onset); BRCA cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg21856205 chr7:94953877 PON1 -0.37 -7.93 -0.3 9.5e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs8022179 0.566 rs959083 chr14:103822687 A/G cg12935359 chr14:103987150 CKB -0.46 -8.51 -0.32 1.27e-16 Monocyte count; BRCA cis rs67311347 0.544 rs7644643 chr3:40350209 C/T cg09455208 chr3:40491958 NA -0.35 -8.78 -0.33 1.5e-17 Renal cell carcinoma; BRCA cis rs4363385 0.818 rs368912 chr1:153016204 C/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.46 -0.32 1.88e-16 Inflammatory skin disease; BRCA cis rs2070488 0.804 rs13100195 chr3:38482539 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.72 0.57 1.83e-57 Electrocardiographic conduction measures; BRCA cis rs4730250 0.707 rs257372 chr7:106796977 T/G cg02696742 chr7:106810147 HBP1 -0.58 -9.57 -0.35 2.29e-20 Osteoarthritis; BRCA cis rs7408868 1.000 rs6512018 chr19:15282138 T/C cg14696996 chr19:15285081 NOTCH3 1.01 14.59 0.5 8.07e-42 Pulse pressure; BRCA trans rs61931739 0.534 rs11053047 chr12:34161084 C/T cg26384229 chr12:38710491 ALG10B 0.69 14.65 0.5 4.31e-42 Morning vs. evening chronotype; BRCA cis rs7590368 0.962 rs13431633 chr2:10960225 T/C cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.02e-15 Educational attainment (years of education); BRCA cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg16586182 chr3:47516702 SCAP -0.55 -12.34 -0.44 1.63e-31 Colorectal cancer; BRCA cis rs7011049 1.000 rs74457055 chr8:53842669 T/G cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs7568458 0.709 rs2592551 chr2:85780131 G/A cg02493740 chr2:85810744 VAMP5 -0.54 -11.2 -0.41 1.01e-26 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2115630 0.755 rs7169629 chr15:85191274 C/G cg11189052 chr15:85197271 WDR73 0.38 9.36 0.35 1.29e-19 P wave terminal force; BRCA cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg05340658 chr4:99064831 C4orf37 0.63 15.18 0.51 1.17e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg00074818 chr8:8560427 CLDN23 0.37 8.09 0.3 3.08e-15 Obesity-related traits; BRCA cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg27535305 chr1:53392650 SCP2 -0.35 -8.67 -0.32 3.47e-17 Monocyte count; BRCA cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08704250 chr15:31115839 NA -0.5 -12.71 -0.45 3.75e-33 Huntington's disease progression; BRCA cis rs3761847 0.622 rs10818498 chr9:123787566 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 7.86 0.3 1.67e-14 Rheumatoid arthritis; BRCA cis rs1941023 0.584 rs2241921 chr11:60164302 C/T cg08716584 chr11:60157161 MS4A7 -0.44 -10.44 -0.38 1.16e-23 Congenital heart disease (maternal effect); BRCA cis rs7572733 0.534 rs700687 chr2:198721560 A/T cg00792783 chr2:198669748 PLCL1 0.47 10.12 0.37 1.95e-22 Dermatomyositis; BRCA cis rs477692 0.685 rs551491 chr10:131397821 G/A cg24747557 chr10:131355152 MGMT -0.4 -10.03 -0.37 4.4e-22 Response to temozolomide; BRCA cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.27 -0.41 5.36e-27 IgG glycosylation; BRCA cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg17509989 chr5:176798049 RGS14 0.66 13.04 0.46 1.22e-34 Hemoglobin concentration;Hematocrit; BRCA cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg08704250 chr15:31115839 NA 0.33 8.68 0.32 3.28e-17 Huntington's disease progression; BRCA cis rs736801 0.964 rs17622656 chr5:131820997 A/G cg14196790 chr5:131705035 SLC22A5 -0.37 -8.66 -0.32 3.75e-17 Breast cancer;Mosquito bite size; BRCA cis rs796364 0.906 rs281766 chr2:200820505 T/G cg23649088 chr2:200775458 C2orf69 0.56 8.11 0.31 2.5e-15 Schizophrenia; BRCA cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.2 0.37 9.91e-23 Electroencephalogram traits; BRCA trans rs2204008 0.743 rs2132212 chr12:38039405 G/A cg06521331 chr12:34319734 NA -0.43 -8.49 -0.32 1.39e-16 Bladder cancer; BRCA cis rs826838 0.967 rs826855 chr12:39114888 T/C cg26384229 chr12:38710491 ALG10B -0.61 -15.83 -0.53 7e-48 Heart rate; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg05552183 chr6:42928497 GNMT 0.79 19.11 0.6 9.96e-65 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7914558 0.933 rs12763665 chr10:104653717 G/A cg04362960 chr10:104952993 NT5C2 0.42 10.14 0.37 1.67e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg21770322 chr7:97807741 LMTK2 0.58 16.99 0.56 1.12e-53 Breast cancer; BRCA cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg15017067 chr4:17643749 FAM184B 0.29 8.97 0.33 3.19e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg22535103 chr8:58192502 C8orf71 -0.6 -13.06 -0.46 1.01e-34 Developmental language disorder (linguistic errors); BRCA trans rs6076960 0.652 rs6085441 chr20:6211383 A/G cg21095983 chr6:86352623 SYNCRIP 0.37 8.21 0.31 1.2e-15 Smooth-surface caries; BRCA cis rs11051970 0.879 rs2733682 chr12:32574608 G/A cg02745156 chr12:32552066 NA 0.28 9.14 0.34 8.14e-19 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs8002861 0.664 rs2218497 chr13:44428793 G/A cg12856521 chr11:46389249 DGKZ 0.37 8.12 0.31 2.49e-15 Leprosy; BRCA cis rs6598955 1.000 rs6598955 chr1:26619649 C/T cg04990556 chr1:26633338 UBXN11 0.78 17.51 0.57 2.34e-56 Obesity-related traits; BRCA cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -12.62 -0.45 9.4e-33 Body mass index; BRCA cis rs7903847 0.642 rs10882915 chr10:99142184 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6785206 0.803 rs6774512 chr3:128415868 C/T cg16766828 chr3:128327626 NA -0.76 -11.23 -0.41 8.17e-27 Lymphocyte percentage of white cells; BRCA cis rs936229 0.813 rs1378938 chr15:75096443 T/C cg10253484 chr15:75165896 SCAMP2 -0.48 -9.32 -0.35 1.86e-19 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7267979 0.773 rs6132821 chr20:25226192 A/G cg08601574 chr20:25228251 PYGB 0.41 9.62 0.36 1.49e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs832540 0.669 rs173764 chr5:56198920 C/T cg24549020 chr5:56110836 MAP3K1 0.38 8.13 0.31 2.28e-15 Coronary artery disease; BRCA trans rs61931739 0.534 rs10844732 chr12:34037104 A/C cg26384229 chr12:38710491 ALG10B 0.68 14.28 0.49 2.34e-40 Morning vs. evening chronotype; BRCA cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg03213289 chr20:61660250 NA 0.62 15.98 0.53 1.29e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg00999904 chr2:3704751 ALLC 0.44 8.27 0.31 7.52e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA trans rs853679 0.607 rs67662114 chr6:27932301 G/A cg01620082 chr3:125678407 NA -0.98 -11.11 -0.4 2.38e-26 Depression; BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg12311346 chr5:56204834 C5orf35 -0.78 -15.47 -0.52 4.44e-46 Initial pursuit acceleration; BRCA cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.95 0.37 8.73e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg17724175 chr1:150552817 MCL1 -0.26 -8.47 -0.32 1.74e-16 Tonsillectomy; BRCA cis rs9329289 0.510 rs9733402 chr10:2551532 G/A cg15501526 chr10:2543763 NA 0.44 10.24 0.38 7.15e-23 Age-related hearing impairment; BRCA cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg03433033 chr1:76189801 ACADM 0.75 16.95 0.56 1.74e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs4819052 0.634 rs8128636 chr21:46690633 G/T cg11663144 chr21:46675770 NA -0.47 -10.97 -0.4 8.73e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg12386194 chr3:101231763 SENP7 0.55 11.25 0.41 6.75e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs7512552 0.839 rs6662108 chr1:150420541 G/T cg15654264 chr1:150340011 RPRD2 0.4 8.61 0.32 5.71e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7927771 0.896 rs12794570 chr11:47658314 C/T cg18512352 chr11:47633146 NA -0.37 -8.83 -0.33 9.99e-18 Subjective well-being; BRCA cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.13 0.31 2.17e-15 Breast cancer; BRCA cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg18876405 chr7:65276391 NA -0.55 -13.31 -0.47 7.27e-36 Aortic root size; BRCA cis rs7824557 0.767 rs17797443 chr8:11164012 T/C cg21775007 chr8:11205619 TDH 0.61 11.79 0.42 3.49e-29 Retinal vascular caliber; BRCA cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg06550200 chr5:1325588 CLPTM1L -0.66 -14.34 -0.49 1.2e-40 Lung cancer; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01171360 chr6:293285 DUSP22 0.56 11.53 0.41 4.52e-28 Menopause (age at onset); BRCA cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg13319975 chr6:146136371 FBXO30 0.34 7.95 0.3 8.78e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9612 1.000 rs346544 chr19:44256205 A/G cg08581076 chr19:44259116 C19orf61 0.51 9.65 0.36 1.15e-20 Exhaled nitric oxide output; BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.54 -11.02 -0.4 5.61e-26 Lymphocyte counts; BRCA cis rs7647973 1.000 rs2140270 chr3:49439440 A/G cg07636037 chr3:49044803 WDR6 -0.73 -15.84 -0.53 6.49e-48 Menarche (age at onset); BRCA cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg05347473 chr6:146136440 FBXO30 0.43 8.44 0.32 2.08e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg18230493 chr5:56204884 C5orf35 -0.68 -13.56 -0.47 5.11e-37 Initial pursuit acceleration; BRCA cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.45 -10.27 -0.38 5.4e-23 Calcium levels; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.59 -0.32 6.88e-17 Total body bone mineral density; BRCA cis rs12586317 0.513 rs74564132 chr14:35472882 C/T cg16230307 chr14:35515116 FAM177A1 0.73 15.28 0.52 3.85e-45 Psoriasis; BRCA cis rs6942756 0.876 rs822038 chr7:129065477 A/G cg02491457 chr7:128862824 NA -0.57 -11.84 -0.42 2.31e-29 White matter hyperintensity burden; BRCA cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg05234568 chr11:5960015 NA -0.51 -11.35 -0.41 2.59e-27 DNA methylation (variation); BRCA trans rs7829975 0.688 rs6601703 chr8:8380224 A/G cg21775007 chr8:11205619 TDH 0.43 8.83 0.33 9.81e-18 Mood instability; BRCA cis rs2882667 0.858 rs17207870 chr5:138387737 T/C cg04439458 chr5:138467593 SIL1 -0.43 -10.78 -0.39 5.25e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs921968 0.510 rs2577761 chr2:219462500 G/A cg10223061 chr2:219282414 VIL1 -0.27 -8.08 -0.3 3.13e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg03146154 chr1:46216737 IPP 0.45 10.04 0.37 4.15e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1577917 1.000 rs6914463 chr6:86653415 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.3 -0.41 3.95e-27 Response to antipsychotic treatment; BRCA trans rs8002861 0.641 rs2028813 chr13:44422126 G/T cg12856521 chr11:46389249 DGKZ 0.4 8.69 0.33 3.11e-17 Leprosy; BRCA trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg15556689 chr8:8085844 FLJ10661 0.34 8.17 0.31 1.6e-15 Neuroticism; BRCA trans rs1459104 0.706 rs35228933 chr11:55027673 G/A cg03929089 chr4:120376271 NA 0.65 7.86 0.3 1.65e-14 Body mass index; BRCA cis rs17401966 0.838 rs17034643 chr1:10332102 A/G cg03954927 chr1:10346856 KIF1B -0.44 -13.92 -0.48 1.19e-38 Hepatocellular carcinoma; BRCA cis rs6582630 0.502 rs1589390 chr12:38416139 C/T cg26384229 chr12:38710491 ALG10B -0.41 -9.47 -0.35 5.45e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs2304069 0.954 rs1433010 chr5:149383954 C/G cg12661370 chr5:149340060 SLC26A2 -0.56 -8.18 -0.31 1.49e-15 HIV-1 control; BRCA trans rs6952808 0.689 rs79950306 chr7:2022063 C/G cg04565464 chr8:145669602 NFKBIL2 0.43 9.85 0.36 2.16e-21 Bipolar disorder and schizophrenia; BRCA cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg08213375 chr14:104286397 PPP1R13B 0.66 18.66 0.59 2.41e-62 Schizophrenia; BRCA cis rs932287 0.505 rs2742536 chr11:8909816 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.55 -12.61 -0.45 9.93e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg12927641 chr6:109611667 NA -0.42 -10.81 -0.39 4.03e-25 Reticulocyte fraction of red cells; BRCA cis rs9359856 0.564 rs72915918 chr6:90430792 G/C cg13799429 chr6:90582589 CASP8AP2 -0.7 -8.45 -0.32 1.95e-16 Bipolar disorder; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg02353165 chr6:42928485 GNMT 0.77 18.94 0.6 8.14e-64 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg22920501 chr2:26401640 FAM59B -0.63 -11.25 -0.41 6.42e-27 Gut microbiome composition (summer); BRCA cis rs17401966 1.000 rs3753037 chr1:10355834 C/T cg03954927 chr1:10346856 KIF1B 0.44 13.01 0.46 1.7e-34 Hepatocellular carcinoma; BRCA cis rs7267979 1.000 rs2500446 chr20:25339664 C/T cg08601574 chr20:25228251 PYGB -0.38 -9.04 -0.34 1.88e-18 Liver enzyme levels (alkaline phosphatase); BRCA trans rs11098499 0.863 rs6858777 chr4:120475966 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11890956 chr21:40555474 PSMG1 1.06 31.74 0.78 1.95e-133 Cognitive function; BRCA cis rs2732480 0.500 rs12829841 chr12:48628739 A/G cg04545296 chr12:48745243 ZNF641 0.24 7.92 0.3 1.06e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs3784262 0.528 rs11071367 chr15:58354152 G/A cg12031962 chr15:58353849 ALDH1A2 0.35 8.96 0.33 3.51e-18 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1577917 0.958 rs4707223 chr6:86509802 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.42 -0.32 2.48e-16 Response to antipsychotic treatment; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg23131131 chr22:24373011 LOC391322 -0.48 -11.66 -0.42 1.27e-28 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7568458 0.660 rs2289972 chr2:85766545 C/T cg02493740 chr2:85810744 VAMP5 -0.54 -11.23 -0.41 8.17e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs501916 0.605 rs17332642 chr15:48080805 G/A cg16110827 chr15:48056943 SEMA6D -0.39 -8.22 -0.31 1.16e-15 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.21 0.41 9.5e-27 Bipolar disorder; BRCA cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg06046430 chr4:77819534 ANKRD56 0.61 13.63 0.47 2.57e-37 Emphysema distribution in smoking; BRCA cis rs7131987 0.845 rs7299861 chr12:29409667 G/A cg09582351 chr12:29534625 ERGIC2 -0.39 -9.37 -0.35 1.26e-19 QT interval; BRCA cis rs2370759 1.000 rs16933225 chr10:32599464 C/T cg18270830 chr10:32634957 EPC1 0.53 9.32 0.35 1.93e-19 Sexual dysfunction (female); BRCA cis rs3862260 0.509 rs12076924 chr1:120165826 C/T cg11530693 chr1:120165357 ZNF697 0.62 14.96 0.51 1.36e-43 Systemic lupus erythematosus; BRCA cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg03161606 chr19:29218774 NA 0.42 7.95 0.3 8.74e-15 Methadone dose in opioid dependence; BRCA cis rs1003719 0.788 rs9974286 chr21:38456832 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.58 -13.62 -0.47 2.91e-37 Eye color traits; BRCA cis rs60843830 1.000 rs17714252 chr2:285471 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 19.51 0.61 7.86e-67 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs77106637 0.860 rs75896506 chr11:72429579 G/A cg03713592 chr11:72463424 ARAP1 1.13 16.23 0.54 7.74e-50 Type 2 diabetes; BRCA cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg24549020 chr5:56110836 MAP3K1 0.66 13.4 0.47 2.87e-36 Initial pursuit acceleration; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.74 16.03 0.54 7.56e-49 Lymphocyte counts; BRCA cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.34 -0.35 1.5700000000000001e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs12135062 0.851 rs2651927 chr1:3101762 A/C cg25382214 chr1:3105252 PRDM16 -0.33 -7.93 -0.3 9.93e-15 Migraine; BRCA trans rs3780486 0.801 rs56687083 chr9:33132134 A/G cg04842962 chr6:43655489 MRPS18A 1.11 39.06 0.84 1.91e-171 IgG glycosylation; BRCA cis rs736408 0.522 rs998909 chr3:52805093 A/G cg10802521 chr3:52805072 NEK4 -0.36 -9.91 -0.36 1.25e-21 Bipolar disorder; BRCA cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg21770322 chr7:97807741 LMTK2 0.44 11.84 0.42 2.14e-29 Prostate cancer (SNP x SNP interaction); BRCA trans rs804280 0.560 rs10503426 chr8:11589383 A/C cg06636001 chr8:8085503 FLJ10661 0.53 10.1 0.37 2.39e-22 Myopia (pathological); BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg20607798 chr8:58055168 NA 0.59 9.44 0.35 6.62e-20 Developmental language disorder (linguistic errors); BRCA cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg16989086 chr20:62203971 PRIC285 0.53 8.94 0.33 4.21e-18 Glioblastoma; BRCA cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg05535760 chr7:792225 HEATR2 0.71 12.84 0.45 9.94e-34 Cerebrospinal P-tau181p levels; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg16606324 chr3:10149918 C3orf24 0.56 10.95 0.4 1.12e-25 Alzheimer's disease; BRCA cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg07636037 chr3:49044803 WDR6 0.94 26.3 0.72 6.87e-104 Parkinson's disease; BRCA cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg18904891 chr8:8559673 CLDN23 0.65 12.88 0.45 6.56e-34 Obesity-related traits; BRCA cis rs9487051 0.768 rs435611 chr6:109527755 C/T cg21918786 chr6:109611834 NA -0.34 -9.0 -0.34 2.53e-18 Reticulocyte fraction of red cells; BRCA cis rs9649213 0.614 rs62479858 chr7:97924226 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.6 -15.65 -0.53 5.37e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.12 0.66 6.09e-81 Chronic sinus infection; BRCA cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg19539972 chr4:7069911 GRPEL1 -0.59 -12.42 -0.44 6.77e-32 Monocyte percentage of white cells; BRCA trans rs61931739 0.534 rs1490113 chr12:34132394 A/G cg26384229 chr12:38710491 ALG10B 0.66 13.9 0.48 1.49e-38 Morning vs. evening chronotype; BRCA cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06544989 chr22:39130855 UNC84B 0.35 8.35 0.31 4.17e-16 Menopause (age at onset); BRCA cis rs754466 0.510 rs10824579 chr10:79590685 C/T cg17075019 chr10:79541650 NA -0.64 -16.57 -0.55 1.38e-51 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg17143192 chr8:8559678 CLDN23 0.57 11.08 0.4 3.3e-26 Obesity-related traits; BRCA cis rs6598955 0.671 rs12085416 chr1:26627835 T/C cg00852783 chr1:26633632 UBXN11 -0.47 -8.51 -0.32 1.22e-16 Obesity-related traits; BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -13.02 -0.46 1.58e-34 Platelet count; BRCA cis rs2046867 0.862 rs6788139 chr3:72835630 A/G cg25664220 chr3:72788482 NA 0.38 8.42 0.32 2.54e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs34779708 0.733 rs7081597 chr10:35546331 G/C cg03585969 chr10:35415529 CREM 0.44 8.95 0.33 3.77e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11229555 0.645 rs7946522 chr11:58197905 G/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg02574844 chr11:5959923 NA -0.38 -8.33 -0.31 4.91e-16 DNA methylation (variation); BRCA cis rs9942416 0.630 rs253388 chr5:74975912 A/G cg19683494 chr5:74908142 NA -0.5 -8.88 -0.33 6.73e-18 Age-related disease endophenotypes; BRCA cis rs6088813 1.000 rs6088813 chr20:33975181 C/A cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.1e-17 Height; BRCA cis rs6964587 1.000 rs6967256 chr7:91643219 G/A cg17063962 chr7:91808500 NA 0.57 13.47 0.47 1.4e-36 Breast cancer; BRCA trans rs11039798 0.614 rs116427493 chr11:48776141 C/T cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs1003719 0.737 rs2835587 chr21:38461795 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.03 0.49 3.72e-39 Eye color traits; BRCA cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg09904177 chr6:26538194 HMGN4 -0.55 -17.29 -0.56 3.25e-55 Intelligence (multi-trait analysis); BRCA cis rs30380 0.553 rs27527 chr5:96151968 C/A cg16492584 chr5:96139282 ERAP1 -0.47 -10.78 -0.39 5.13e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg27170947 chr2:26402098 FAM59B -0.91 -15.7 -0.53 3.27e-47 Gut microbiome composition (summer); BRCA cis rs858239 0.600 rs6961406 chr7:23134891 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.89 0.43 1.36e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00149659 chr3:10157352 C3orf10 0.69 10.34 0.38 2.81e-23 Alzheimer's disease; BRCA cis rs9467773 1.000 rs6456733 chr6:26566804 C/T cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.13e-20 Intelligence (multi-trait analysis); BRCA cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg18016565 chr1:150552671 MCL1 0.34 8.14 0.31 2e-15 Tonsillectomy; BRCA cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg11764359 chr7:65958608 NA -0.75 -16.59 -0.55 1.12e-51 Aortic root size; BRCA cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg06713675 chr4:122721982 EXOSC9 -0.53 -12.5 -0.44 3.08e-32 Type 2 diabetes; BRCA cis rs7178424 0.905 rs7177173 chr15:62236804 T/A cg00456672 chr15:62358751 C2CD4A 0.43 9.82 0.36 2.82e-21 Height; BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.97e-20 Tonsillectomy; BRCA cis rs7300001 0.667 rs7298716 chr12:110506181 A/T cg12870014 chr12:110450643 ANKRD13A 0.59 8.05 0.3 3.99e-15 Headache; BRCA cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg17063962 chr7:91808500 NA 0.55 12.92 0.46 4.12e-34 Breast cancer; BRCA cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg21132104 chr15:45694354 SPATA5L1 0.75 17.09 0.56 3.4e-54 Homoarginine levels; BRCA cis rs3815308 0.530 rs2240129 chr19:2197734 C/T cg09261902 chr19:2140048 AP3D1 0.34 8.5 0.32 1.39e-16 Breast cancer; BRCA cis rs6684514 1.000 rs12038217 chr1:156248297 C/T cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs12950390 0.853 rs66471233 chr17:45867086 C/T cg03474202 chr17:45855739 NA -0.46 -12.02 -0.43 3.9e-30 IgG glycosylation; BRCA cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg09754948 chr16:28834200 ATXN2L 0.45 8.85 0.33 8.64e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs367943 1.000 rs348931 chr5:112812864 G/C cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg11941060 chr3:133502564 NA 0.59 14.85 0.51 4.55e-43 Iron status biomarkers; BRCA cis rs1451375 0.652 rs1470747 chr7:50627009 C/T cg18232548 chr7:50535776 DDC 0.38 7.98 0.3 6.84e-15 Malaria; BRCA cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg12935359 chr14:103987150 CKB -0.61 -13.9 -0.48 1.51e-38 Intelligence (multi-trait analysis); BRCA cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg12756686 chr19:29218302 NA 0.47 8.3 0.31 6.15e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs35740288 0.895 rs3743332 chr15:86303751 T/C cg20737812 chr15:86336631 KLHL25 -0.32 -8.01 -0.3 5.33e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg23708337 chr7:1209742 NA 0.43 8.29 0.31 6.92e-16 Longevity;Endometriosis; BRCA cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg15839431 chr19:19639596 YJEFN3 0.35 8.05 0.3 4.14e-15 Bipolar disorder; BRCA cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg25767906 chr1:53392781 SCP2 0.38 8.71 0.33 2.68e-17 Monocyte count; BRCA cis rs6964587 1.000 rs34548928 chr7:91668365 G/A cg17063962 chr7:91808500 NA 0.52 12.38 0.44 1.05e-31 Breast cancer; BRCA cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg08645402 chr16:4508243 NA 0.39 9.17 0.34 6.27e-19 Schizophrenia; BRCA cis rs36051895 0.659 rs62541540 chr9:5040080 A/G cg02405213 chr9:5042618 JAK2 -0.48 -8.65 -0.32 4.22e-17 Pediatric autoimmune diseases; BRCA cis rs1348850 0.914 rs3813259 chr2:178257214 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 9.85 0.36 2.15e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs61931739 1.000 rs61931739 chr12:34089973 C/T cg26384229 chr12:38710491 ALG10B -0.41 -8.99 -0.34 2.77e-18 Morning vs. evening chronotype; BRCA cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.63 13.41 0.47 2.53e-36 Age-related macular degeneration (geographic atrophy); BRCA cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg18904891 chr8:8559673 CLDN23 0.62 12.18 0.43 7.77e-31 Obesity-related traits; BRCA cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.24 -0.34 3.54e-19 Menopause (age at onset); BRCA cis rs6952809 0.532 rs2057840 chr7:2432797 C/G cg23289794 chr7:2394357 EIF3B -0.46 -9.55 -0.35 2.62e-20 Multiple sclerosis; BRCA cis rs9287719 0.967 rs10929686 chr2:10743705 A/C cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg02475777 chr4:1388615 CRIPAK 0.56 11.16 0.4 1.45e-26 Longevity; BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg25036284 chr2:26402008 FAM59B -0.63 -10.48 -0.38 8.25e-24 Gut microbiome composition (summer); BRCA cis rs2806561 0.765 rs1612905 chr1:23510023 G/T cg12483005 chr1:23474871 LUZP1 0.46 10.24 0.38 6.83e-23 Height; BRCA cis rs7267979 0.932 rs1985737 chr20:25591468 T/A cg08601574 chr20:25228251 PYGB 0.33 7.95 0.3 8.29e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg11062466 chr8:58055876 NA 0.44 10.42 0.38 1.42e-23 Developmental language disorder (linguistic errors); BRCA cis rs13118159 0.801 rs10024996 chr4:1328297 G/A cg20887711 chr4:1340912 KIAA1530 0.35 8.23 0.31 1.05e-15 Longevity; BRCA cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.91 0.33 5.35e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg18404041 chr3:52824283 ITIH1 -0.43 -12.81 -0.45 1.32e-33 Bipolar disorder; BRCA cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg19717773 chr7:2847554 GNA12 -0.4 -8.71 -0.33 2.55e-17 Height; BRCA cis rs600806 0.778 rs891379 chr1:110003605 A/G cg20591472 chr1:110008990 SYPL2 0.31 7.89 0.3 1.31e-14 Intelligence (multi-trait analysis); BRCA cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg06671706 chr8:8559999 CLDN23 0.45 8.76 0.33 1.69e-17 Obesity-related traits; BRCA cis rs7729447 0.776 rs4867472 chr5:32693566 C/T cg16267343 chr5:32710456 NPR3 0.41 8.27 0.31 7.85e-16 Blood pressure; BRCA cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.54 0.77 5.46e-127 Chronic sinus infection; BRCA cis rs2882667 0.690 rs7736925 chr5:138154530 C/G cg04439458 chr5:138467593 SIL1 0.36 8.88 0.33 6.46e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.69 -0.53 3.55e-47 Chronic sinus infection; BRCA cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg24069376 chr3:38537580 EXOG -0.33 -9.43 -0.35 7.59e-20 Electrocardiographic conduction measures; BRCA cis rs56114371 0.777 rs200481 chr6:27773832 A/T cg26587870 chr6:27730563 NA -0.49 -7.86 -0.3 1.69e-14 Breast cancer; BRCA cis rs6142102 0.961 rs6059587 chr20:32542926 C/G cg24642439 chr20:33292090 TP53INP2 0.42 7.84 0.3 1.93e-14 Skin pigmentation; BRCA cis rs8180040 0.966 rs57346147 chr3:47410564 C/G cg27129171 chr3:47204927 SETD2 -0.69 -16.24 -0.54 6.31e-50 Colorectal cancer; BRCA cis rs7737355 0.947 rs3776004 chr5:130879431 G/C cg06307176 chr5:131281290 NA 0.54 10.66 0.39 1.53e-24 Life satisfaction; BRCA cis rs9399135 0.967 rs6569990 chr6:135365818 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.46e-31 Red blood cell count; BRCA cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg11608241 chr8:8085544 FLJ10661 0.31 8.63 0.32 4.79e-17 Mood instability; BRCA cis rs10504229 1.000 rs72650899 chr8:58180525 G/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.56 -0.32 8.13e-17 Developmental language disorder (linguistic errors); BRCA cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.81e-15 Prostate cancer; BRCA cis rs1865760 1.000 rs12209482 chr6:25909229 T/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.43 0.38 1.29e-23 Height; BRCA cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg26587870 chr6:27730563 NA -0.4 -8.39 -0.31 3.2e-16 Parkinson's disease; BRCA cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg10792982 chr14:105748885 BRF1 0.5 11.54 0.42 3.97e-28 Mean platelet volume;Platelet distribution width; BRCA trans rs116095464 0.558 rs10055993 chr5:264296 A/C cg00938859 chr5:1591904 SDHAP3 0.74 9.39 0.35 1.07e-19 Breast cancer; BRCA cis rs6866344 0.697 rs62392833 chr5:178135452 T/A cg03877680 chr5:178157825 ZNF354A 0.8 14.77 0.5 1.05e-42 Neutrophil percentage of white cells; BRCA cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg18351406 chr4:77819688 ANKRD56 0.62 13.96 0.48 7.71e-39 Emphysema distribution in smoking; BRCA cis rs6582630 0.516 rs12814528 chr12:38296111 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.05 -0.37 3.56e-22 Drug-induced liver injury (flucloxacillin); BRCA trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg03929089 chr4:120376271 NA 0.49 8.2 0.31 1.36e-15 Axial length; BRCA cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg08822215 chr16:89438651 ANKRD11 0.45 9.51 0.35 3.88e-20 Multiple myeloma (IgH translocation); BRCA cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg11843238 chr5:131593191 PDLIM4 0.35 7.95 0.3 8.19e-15 Breast cancer; BRCA cis rs12579753 1.000 rs17748942 chr12:82170478 G/A cg07988820 chr12:82153109 PPFIA2 -0.6 -9.6 -0.35 1.84e-20 Resting heart rate; BRCA cis rs919433 0.680 rs1116734 chr2:198365043 C/G cg00792783 chr2:198669748 PLCL1 0.38 8.53 0.32 1.08e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs11098499 0.954 rs35063680 chr4:120387102 T/C cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs763121 0.853 rs138716 chr22:39146527 C/T cg06022373 chr22:39101656 GTPBP1 0.72 15.36 0.52 1.52e-45 Menopause (age at onset); BRCA cis rs1580019 0.885 rs4580942 chr7:32496435 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.52 0.32 1.13e-16 Cognitive ability; BRCA cis rs11098499 0.874 rs9995277 chr4:120108603 G/A cg09307838 chr4:120376055 NA 0.6 11.11 0.4 2.42e-26 Corneal astigmatism; BRCA cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg20607287 chr7:12443886 VWDE -0.57 -8.09 -0.3 3.06e-15 Coronary artery disease; BRCA cis rs67460515 0.892 rs13059340 chr3:161062631 T/C cg03342759 chr3:160939853 NMD3 -0.81 -18.07 -0.58 2.79e-59 Parkinson's disease; BRCA trans rs1459104 0.929 rs67114977 chr11:55223023 T/G cg15704280 chr7:45808275 SEPT13 0.67 7.9 0.3 1.21e-14 Body mass index; BRCA cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg07262247 chr5:131593730 PDLIM4 -0.34 -8.12 -0.31 2.35e-15 Acylcarnitine levels; BRCA cis rs10883723 0.810 rs7917525 chr10:104246755 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.76 0.62 3.45e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs13046373 0.508 rs1507393 chr21:31992779 A/G cg06468780 chr21:31798236 KRTAP13-3 0.33 8.27 0.31 7.64e-16 HDL cholesterol; BRCA cis rs1577917 0.682 rs1173417 chr6:86403941 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.34 9.46 0.35 5.66e-20 Response to antipsychotic treatment; BRCA cis rs10883723 0.810 rs1409311 chr10:104282160 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.34 0.59 1.07e-60 Allergic disease (asthma, hay fever or eczema); BRCA cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 11.0 0.4 6.58e-26 Rheumatoid arthritis; BRCA cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.89 0.36 1.53e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9814567 1.000 rs7433991 chr3:134312292 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.32 8.7 0.33 2.88e-17 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.52 0.35 3.62e-20 Parkinson's disease; BRCA cis rs807669 0.525 rs2073740 chr22:19196112 A/C cg02655711 chr22:19163373 SLC25A1 -0.42 -9.52 -0.35 3.37e-20 Metabolite levels; BRCA cis rs9341808 0.718 rs3805922 chr6:80891989 A/G cg08355045 chr6:80787529 NA 0.39 9.94 0.37 9.37e-22 Sitting height ratio; BRCA cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg01689657 chr7:91764605 CYP51A1 0.26 9.33 0.35 1.68e-19 Breast cancer; BRCA cis rs4948102 0.642 rs766333 chr7:56126704 T/A cg09872392 chr7:56161020 PHKG1 -0.48 -12.04 -0.43 3.12e-30 Plasma homocysteine levels (post-methionine load test); BRCA cis rs4478858 0.684 rs2271074 chr1:31734841 C/T cg00250761 chr1:31883323 NA -0.32 -8.26 -0.31 8.42e-16 Alcohol dependence; BRCA cis rs17270561 0.609 rs7769908 chr6:25760539 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs495337 1.000 rs653423 chr20:48514174 C/T cg17835207 chr20:48524531 SPATA2 -0.6 -13.75 -0.48 6.93e-38 Psoriasis; BRCA cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg08085267 chr17:45401833 C17orf57 0.62 12.78 0.45 1.83e-33 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg08999081 chr20:33150536 PIGU -0.33 -8.53 -0.32 1.05e-16 Glomerular filtration rate (creatinine); BRCA cis rs4363385 0.818 rs382292 chr1:153006641 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.08e-14 Inflammatory skin disease; BRCA cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.58 0.42 2.79e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.58 -0.32 7.15e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg11247378 chr22:39784982 NA 0.63 13.89 0.48 1.67e-38 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg11789530 chr4:8429930 ACOX3 0.58 13.75 0.48 7.12e-38 Response to antineoplastic agents; BRCA cis rs853679 0.517 rs12332979 chr6:28141548 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.99 0.3 6.41e-15 Depression; BRCA cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.4 0.32 2.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7091068 0.671 rs591392 chr10:95406081 G/A cg20715218 chr10:95462985 C10orf4 -0.47 -8.49 -0.32 1.5e-16 Urinary tract infection frequency; BRCA cis rs6963495 0.615 rs2697021 chr7:105151029 A/C cg19920283 chr7:105172520 RINT1 0.43 8.93 0.33 4.67e-18 Bipolar disorder (body mass index interaction); BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg08888203 chr3:10149979 C3orf24 -0.62 -13.72 -0.48 1.01e-37 Alzheimer's disease; BRCA cis rs9399135 0.967 rs2297340 chr6:135376058 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.31 0.44 2.06e-31 Red blood cell count; BRCA cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg10295955 chr4:187884368 NA -0.95 -27.58 -0.74 6.69e-111 Lobe attachment (rater-scored or self-reported); BRCA cis rs7336332 0.598 rs7669 chr13:28009851 C/T cg01674679 chr13:27998804 GTF3A -0.46 -7.88 -0.3 1.39e-14 Weight; BRCA cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg08069147 chr6:88032118 GJB7;C6orf162 0.61 12.44 0.44 5.64e-32 Monocyte percentage of white cells; BRCA cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7246657 0.722 rs10412510 chr19:38075944 A/G cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA trans rs4596713 0.538 rs4744829 chr9:71748416 G/C cg16512924 chr15:28394682 HERC2 0.41 9.85 0.36 2.06e-21 Headache; BRCA cis rs10028773 0.600 rs4001390 chr4:120265783 G/C cg09307838 chr4:120376055 NA 0.59 12.89 0.45 5.65e-34 Educational attainment; BRCA cis rs6831352 0.879 rs56295995 chr4:100060899 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.68 -0.36 8.73e-21 Alcohol dependence; BRCA cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg22800045 chr5:56110881 MAP3K1 -0.47 -9.34 -0.35 1.54e-19 Initial pursuit acceleration; BRCA cis rs5769707 0.609 rs2007024 chr22:49988815 C/T cg05373962 chr22:49881684 NA -0.29 -8.06 -0.3 3.75e-15 Monocyte count;Monocyte percentage of white cells; BRCA cis rs1011018 0.628 rs17177358 chr7:139456812 A/G cg03224163 chr7:139420300 HIPK2 -0.6 -9.06 -0.34 1.53e-18 Systolic blood pressure; BRCA cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg14863265 chr7:2801509 GNA12 -0.49 -10.81 -0.39 4.07e-25 Height; BRCA cis rs4285028 0.699 rs12629742 chr3:121614895 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.73 -13.17 -0.46 3.23e-35 Multiple sclerosis; BRCA cis rs56104184 0.775 rs73063505 chr19:49402765 T/C cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg25208724 chr1:156163844 SLC25A44 0.88 17.78 0.58 9.67e-58 Testicular germ cell tumor; BRCA cis rs897080 0.518 rs1067330 chr2:44627822 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.55 10.5 0.38 6.83e-24 Height; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg27588902 chr6:42928151 GNMT -0.31 -10.19 -0.37 1.07e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2032447 0.639 rs198810 chr6:26128618 A/G cg03264133 chr6:25882463 NA 0.41 8.71 0.33 2.61e-17 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg12437481 chr16:420112 MRPL28 -0.48 -11.59 -0.42 2.43e-28 Bone mineral density (spine);Bone mineral density; BRCA cis rs11758351 1.000 rs41266807 chr6:26199822 A/G cg01420254 chr6:26195488 NA 0.56 8.79 0.33 1.41e-17 Gout;Renal underexcretion gout; BRCA cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg21782813 chr7:2030301 MAD1L1 0.35 9.49 0.35 4.36e-20 Bipolar disorder and schizophrenia; BRCA cis rs2859741 0.546 rs2133910 chr1:37478785 G/T cg09363841 chr1:37513479 NA -0.5 -10.81 -0.39 3.88e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA trans rs61931739 0.534 rs1387789 chr12:34056304 C/A cg13010199 chr12:38710504 ALG10B 0.4 8.08 0.3 3.19e-15 Morning vs. evening chronotype; BRCA cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs2505998 0.833 rs12767776 chr10:43589513 G/A cg15436174 chr10:43711423 RASGEF1A -0.43 -8.45 -0.32 2.02e-16 Hirschsprung disease; BRCA cis rs7095944 0.614 rs61872084 chr10:126439062 C/T cg08799069 chr10:126477246 METTL10 -0.4 -9.49 -0.35 4.41e-20 Asthma; BRCA cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.2 0.37 1.01e-22 Calcium levels; BRCA cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg06552810 chr11:31128660 NA -0.39 -8.74 -0.33 1.98e-17 Red blood cell count; BRCA cis rs7917772 0.582 rs3936017 chr10:104354424 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2243480 1.000 rs1618893 chr7:66096119 C/T cg18252515 chr7:66147081 NA -0.83 -12.64 -0.45 7.22e-33 Diabetic kidney disease; BRCA cis rs7598759 0.527 rs7571691 chr2:232369401 C/T cg19187155 chr2:232395269 NMUR1 0.68 16.39 0.54 1.21e-50 Noise-induced hearing loss; BRCA trans rs2204008 0.624 rs2320449 chr12:38224190 T/C cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs7599312 0.534 rs7607373 chr2:213409719 G/A cg20637307 chr2:213403960 ERBB4 0.7 19.23 0.61 2.33e-65 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg03213289 chr20:61660250 NA 0.62 16.27 0.54 4.5e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg01877450 chr7:97915802 BRI3 -0.37 -8.33 -0.31 4.82e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.77 -0.42 4.32e-29 Alcohol dependence; BRCA cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg00686598 chr14:53173677 PSMC6 1.17 15.83 0.53 7.63e-48 Alzheimer's disease (late onset); BRCA cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg08213375 chr14:104286397 PPP1R13B 0.65 18.25 0.59 3.25e-60 Schizophrenia; BRCA cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.87 0.36 1.75e-21 Lung cancer in ever smokers; BRCA trans rs3733585 0.631 rs7699671 chr4:10125874 C/T cg26043149 chr18:55253948 FECH -0.38 -8.14 -0.31 2.03e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs138880 0.580 rs28562884 chr22:50312869 T/C cg22709217 chr22:50311962 ALG12;CRELD2 -0.56 -8.21 -0.31 1.24e-15 Schizophrenia; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg08132940 chr7:1081526 C7orf50 -0.6 -8.99 -0.34 2.69e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2204008 0.687 rs11181339 chr12:38322271 G/T cg06521331 chr12:34319734 NA -0.47 -9.24 -0.34 3.67e-19 Bladder cancer; BRCA cis rs12477438 0.798 rs896886 chr2:99652713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.66 14.69 0.5 2.57e-42 Chronic sinus infection; BRCA cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -11.1 -0.4 2.77e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg23711669 chr6:146136114 FBXO30 0.74 17.77 0.58 1.06e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs7917772 0.503 rs7096072 chr10:104299976 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.41e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1451375 1.000 rs2329340 chr7:50620229 C/T cg18232548 chr7:50535776 DDC 0.44 10.2 0.37 9.99e-23 Malaria; BRCA cis rs1784581 0.721 rs9365356 chr6:162414789 A/G cg17173639 chr6:162384350 PARK2 0.39 9.12 0.34 9.27e-19 Itch intensity from mosquito bite; BRCA cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg00071950 chr4:10020882 SLC2A9 0.45 10.63 0.39 2.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9790314 0.846 rs899275 chr3:161042104 T/C cg04691961 chr3:161091175 C3orf57 -0.42 -10.43 -0.38 1.25e-23 Morning vs. evening chronotype; BRCA cis rs7408868 0.520 rs10417567 chr19:15308068 C/T cg14696996 chr19:15285081 NOTCH3 -0.82 -12.08 -0.43 2.05e-30 Pulse pressure; BRCA cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg06671706 chr8:8559999 CLDN23 0.45 8.66 0.32 3.72e-17 Obesity-related traits; BRCA cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.47 9.79 0.36 3.49e-21 Tonsillectomy; BRCA trans rs11098499 0.909 rs28884220 chr4:120307211 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs9467773 0.534 rs34453863 chr6:26628005 T/C cg09904177 chr6:26538194 HMGN4 0.42 11.91 0.43 1.09e-29 Intelligence (multi-trait analysis); BRCA cis rs524281 0.647 rs2302883 chr11:65824994 T/C cg14036092 chr11:66035641 RAB1B -0.41 -8.95 -0.33 3.89e-18 Electroencephalogram traits; BRCA cis rs752010 0.905 rs4525030 chr1:42091307 G/C cg06885757 chr1:42089581 HIVEP3 0.24 8.66 0.32 3.9e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.83 0.3 2.1e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg11843238 chr5:131593191 PDLIM4 0.41 10.35 0.38 2.63e-23 Acylcarnitine levels; BRCA cis rs11690935 1.000 rs6433311 chr2:172549248 A/G cg13550731 chr2:172543902 DYNC1I2 0.94 32.1 0.79 2.31e-135 Schizophrenia; BRCA cis rs12579753 0.917 rs2401002 chr12:82215870 C/T cg07988820 chr12:82153109 PPFIA2 -0.51 -8.62 -0.32 5.17e-17 Resting heart rate; BRCA cis rs6570726 1.000 rs436066 chr6:145847127 C/T cg23711669 chr6:146136114 FBXO30 0.65 15.3 0.52 3.01e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs208520 1.000 rs72880045 chr6:66965232 A/C cg07460842 chr6:66804631 NA 0.87 14.42 0.5 5.11e-41 Exhaled nitric oxide output; BRCA cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg24692254 chr21:30365293 RNF160 0.61 15.62 0.53 7.67e-47 Dental caries; BRCA cis rs9790314 0.572 rs13073571 chr3:160665720 G/A cg03342759 chr3:160939853 NMD3 0.44 8.5 0.32 1.35e-16 Morning vs. evening chronotype; BRCA cis rs4787491 0.729 rs7191849 chr16:30023157 T/C cg06326092 chr16:30034487 C16orf92 0.34 8.5 0.32 1.34e-16 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6500602 0.702 rs6500605 chr16:4502410 C/T cg08645402 chr16:4508243 NA 0.44 11.31 0.41 3.51e-27 Schizophrenia; BRCA cis rs11190604 1.000 rs4604805 chr10:102261409 C/G cg07080220 chr10:102295463 HIF1AN 0.56 13.06 0.46 9.66e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -20.03 -0.62 1.28e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs2797160 0.651 rs9491503 chr6:126031682 G/A cg05039488 chr6:79577232 IRAK1BP1 0.37 8.31 0.31 5.85e-16 Endometrial cancer; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.86 -16.53 -0.55 2.29e-51 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg06634786 chr22:41940651 POLR3H -0.57 -8.5 -0.32 1.3e-16 Vitiligo; BRCA cis rs6840360 0.615 rs4696267 chr4:152464500 A/G cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs9486719 1.000 rs12530462 chr6:97053514 C/T cg06623918 chr6:96969491 KIAA0776 -0.75 -13.08 -0.46 8.05e-35 Migraine;Coronary artery disease; BRCA cis rs8014204 0.762 rs10138360 chr14:75293386 A/G cg06637938 chr14:75390232 RPS6KL1 -0.42 -8.82 -0.33 1.13e-17 Caffeine consumption; BRCA cis rs490234 0.812 rs13288963 chr9:128295198 G/A cg14078157 chr9:128172775 NA -0.49 -11.04 -0.4 4.47e-26 Mean arterial pressure; BRCA cis rs1043763 0.826 rs9668430 chr12:122623595 A/G cg14400030 chr12:122498111 BCL7A -0.62 -13.4 -0.47 3.06e-36 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs6570726 1.000 rs405622 chr6:145871897 G/T cg23711669 chr6:146136114 FBXO30 0.64 14.85 0.51 4.32e-43 Lobe attachment (rater-scored or self-reported); BRCA trans rs17685 0.753 rs1639617 chr7:75701728 A/G cg19862616 chr7:65841803 NCRNA00174 0.86 28.7 0.75 5.2e-117 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11252926 0.563 rs10904173 chr10:462885 G/A cg18196295 chr10:418757 DIP2C -0.55 -12.41 -0.44 7.56e-32 Psychosis in Alzheimer's disease; BRCA cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg10057126 chr4:77819792 ANKRD56 0.68 15.42 0.52 7.78e-46 Emphysema distribution in smoking; BRCA cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg06784218 chr1:46089804 CCDC17 -0.51 -12.23 -0.44 4.9e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9467773 1.000 rs10946835 chr6:26533757 C/T cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg20219911 chr3:52813652 ITIH1 0.3 8.45 0.32 1.9e-16 Bipolar disorder; BRCA cis rs73001065 0.792 rs16996148 chr19:19658472 G/T cg03709012 chr19:19516395 GATAD2A 0.83 10.72 0.39 9.3e-25 LDL cholesterol; BRCA cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg26031613 chr14:104095156 KLC1 -0.42 -8.33 -0.31 4.82e-16 Schizophrenia; BRCA cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 1.000 rs295442 chr3:47335881 A/C cg16586182 chr3:47516702 SCAP -0.59 -13.54 -0.47 6.9e-37 Colorectal cancer; BRCA cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg15145296 chr3:125709740 NA -0.55 -8.7 -0.33 2.73e-17 Blood pressure (smoking interaction); BRCA cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.78 0.45 1.82e-33 Bipolar disorder; BRCA cis rs9443189 0.570 rs7755068 chr6:76405700 A/G cg01950844 chr6:76311363 SENP6 0.84 13.53 0.47 7.52e-37 Prostate cancer; BRCA trans rs2204008 0.720 rs11181343 chr12:38323616 G/T cg06521331 chr12:34319734 NA -0.48 -8.73 -0.33 2.13e-17 Bladder cancer; BRCA cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg24692254 chr21:30365293 RNF160 0.37 8.39 0.31 3.19e-16 Pancreatic cancer; BRCA cis rs858239 0.601 rs6461702 chr7:23249273 C/G cg23682824 chr7:23144976 KLHL7 0.35 8.67 0.32 3.49e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs941873 0.900 rs4979862 chr10:81131599 G/A cg11057378 chr10:81107060 PPIF 0.38 9.34 0.35 1.6e-19 Height; BRCA cis rs11608355 0.545 rs4766604 chr12:109892179 T/C cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs6910061 1.000 rs6913027 chr6:11107276 G/A cg27233058 chr6:11094804 LOC221710 0.53 9.35 0.35 1.43e-19 Diabetic kidney disease; BRCA cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg04450456 chr4:17643702 FAM184B 0.38 11.15 0.4 1.66e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs853679 0.825 rs8180562 chr6:28141460 G/A cg01620082 chr3:125678407 NA -0.56 -7.93 -0.3 9.71e-15 Depression; BRCA cis rs870825 0.616 rs6552802 chr4:185620751 C/G cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs6977660 0.714 rs10231980 chr7:19789383 C/G cg07541023 chr7:19748670 TWISTNB 0.63 10.52 0.38 5.51e-24 Thyroid stimulating hormone; BRCA cis rs9814567 1.000 rs7374325 chr3:134275601 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.32 -0.31 5.51e-16 Total body bone mineral density; BRCA trans rs11722228 0.549 rs55848383 chr4:10081117 C/A cg26043149 chr18:55253948 FECH 1.1 23.27 0.68 3.3e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg22764044 chr5:178986830 RUFY1 -0.46 -12.83 -0.45 1.12e-33 Lung cancer; BRCA cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2197308 0.765 rs12824529 chr12:37931656 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.01 0.56 8.73e-54 Morning vs. evening chronotype; BRCA cis rs13118159 0.801 rs7690727 chr4:1340811 C/A cg20887711 chr4:1340912 KIAA1530 0.39 9.3 0.35 2.26e-19 Longevity; BRCA trans rs3733585 0.638 rs13145554 chr4:9979589 C/T cg26043149 chr18:55253948 FECH 0.37 8.05 0.3 3.95e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.1 0.46 6.97e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs847577 0.715 rs12665986 chr7:97719676 A/G cg21770322 chr7:97807741 LMTK2 -0.47 -12.7 -0.45 4.12e-33 Breast cancer; BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.06 0.34 1.61e-18 Platelet count; BRCA cis rs9486719 1.000 rs2472890 chr6:96867646 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.99 0.46 2.1e-34 Migraine;Coronary artery disease; BRCA cis rs559928 0.569 rs7103915 chr11:63944370 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.8 -10.58 -0.39 3.16e-24 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs919433 0.680 rs2124317 chr2:198477606 G/A cg00792783 chr2:198669748 PLCL1 0.35 8.09 0.3 3.07e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.18 0.6 4.14e-65 Platelet count; BRCA cis rs57590327 0.555 rs2053805 chr3:81738414 T/C cg07356753 chr3:81810745 GBE1 -0.47 -11.2 -0.41 1.01e-26 Extraversion; BRCA cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg12751644 chr20:60527061 NA -0.33 -7.91 -0.3 1.12e-14 Body mass index; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.41 -9.79 -0.36 3.36e-21 Lymphocyte counts; BRCA cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg06697600 chr4:7070879 GRPEL1 0.61 10.78 0.39 5.1e-25 Monocyte percentage of white cells; BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -13.19 -0.46 2.72e-35 Platelet count; BRCA cis rs8062405 0.754 rs151179 chr16:28487056 A/G cg16576597 chr16:28551801 NUPR1 0.3 8.0 0.3 5.85e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2749592 0.588 rs2505192 chr10:38395023 G/A cg00409905 chr10:38381863 ZNF37A -0.49 -9.14 -0.34 7.87e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg11366901 chr6:160182831 ACAT2 0.78 15.21 0.52 8.47e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs733592 0.524 rs10875741 chr12:48492922 A/C cg24011408 chr12:48396354 COL2A1 -0.43 -9.43 -0.35 7.26e-20 Plateletcrit; BRCA cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA cis rs6460942 1.000 rs118083671 chr7:12466036 C/T cg10578991 chr7:12443926 VWDE -0.57 -8.06 -0.3 3.71e-15 Coronary artery disease; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg08132940 chr7:1081526 C7orf50 -0.45 -8.04 -0.3 4.3e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg00530320 chr1:46809349 NSUN4 0.48 9.7 0.36 7.74e-21 Menopause (age at onset); BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg00166722 chr3:10149974 C3orf24 0.63 11.33 0.41 3.12e-27 Alzheimer's disease; BRCA cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg06212747 chr3:49208901 KLHDC8B 0.46 9.56 0.35 2.45e-20 Parkinson's disease; BRCA cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.02 -0.37 4.67e-22 Alzheimer's disease (late onset); BRCA cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg09184832 chr6:79620586 NA -0.41 -8.25 -0.31 9.35e-16 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg25019033 chr10:957182 NA -0.43 -8.23 -0.31 1.02e-15 Eosinophil percentage of granulocytes; BRCA trans rs7746199 0.736 rs34105070 chr6:27560805 C/T cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.88e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs17376456 0.877 rs9885329 chr5:93380278 G/A cg25358565 chr5:93447407 FAM172A 1.23 18.35 0.59 1.04e-60 Diabetic retinopathy; BRCA cis rs780096 0.546 rs715326 chr2:27725761 A/G cg12648201 chr2:27665141 KRTCAP3 0.33 8.23 0.31 1.05e-15 Total body bone mineral density; BRCA cis rs1829883 0.898 rs13184400 chr5:98784722 G/A cg08333243 chr5:99726346 NA -0.35 -8.35 -0.31 4.39e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs9420 0.961 rs11601320 chr11:57642617 T/C cg19752551 chr11:57585705 CTNND1 -0.5 -12.23 -0.44 4.57e-31 Schizophrenia; BRCA cis rs887829 0.570 rs4347832 chr2:234593041 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.31 -0.31 5.65e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs758324 0.648 rs152126 chr5:131383667 A/C cg06307176 chr5:131281290 NA -0.44 -8.71 -0.33 2.54e-17 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7904368 0.754 rs17139234 chr10:16849732 G/T cg14835575 chr10:16859367 RSU1 0.62 12.38 0.44 1.1e-31 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs9287719 0.967 rs6712406 chr2:10754420 A/G cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.52 0.41 5.17e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6964587 0.967 rs6973896 chr7:91778465 A/G cg17063962 chr7:91808500 NA 0.61 14.5 0.5 2.19e-41 Breast cancer; BRCA cis rs7631605 0.905 rs6550457 chr3:37182198 T/C cg15934958 chr3:37212084 LRRFIP2 0.4 9.51 0.35 3.91e-20 Cerebrospinal P-tau181p levels; BRCA cis rs13046373 0.535 rs13051529 chr21:32029743 G/C cg24082983 chr21:31802169 KRTAP13-4 0.33 8.07 0.3 3.48e-15 HDL cholesterol; BRCA cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg00409905 chr10:38381863 ZNF37A -0.57 -12.41 -0.44 7.44e-32 Extrinsic epigenetic age acceleration; BRCA cis rs3008870 0.755 rs2815349 chr1:67472280 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.62 13.44 0.47 1.86e-36 Lymphocyte percentage of white cells; BRCA cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg20701182 chr2:24300061 SF3B14 0.57 8.95 0.33 3.91e-18 Lymphocyte counts; BRCA cis rs2204008 0.619 rs11178987 chr12:38201258 C/T cg26384229 chr12:38710491 ALG10B -0.46 -10.52 -0.38 5.62e-24 Bladder cancer; BRCA cis rs10129255 0.518 rs8010020 chr14:107186255 A/G cg07958169 chr14:107095056 NA -0.4 -8.48 -0.32 1.59e-16 Kawasaki disease; BRCA cis rs2882667 0.690 rs1828188 chr5:138171996 A/G cg04439458 chr5:138467593 SIL1 0.31 7.81 0.3 2.44e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs17401966 1.000 rs4846208 chr1:10313839 T/C cg03954927 chr1:10346856 KIF1B 0.45 12.8 0.45 1.41e-33 Hepatocellular carcinoma; BRCA trans rs12517041 1.000 rs34515966 chr5:23310388 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.49 -8.62 -0.32 5.14e-17 Calcium levels; BRCA cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg14844989 chr11:31128820 NA 0.47 9.96 0.37 7.98e-22 Red blood cell count; BRCA cis rs6866344 0.570 rs1071881 chr5:178135917 C/T cg03877680 chr5:178157825 ZNF354A 0.86 17.27 0.56 4.03e-55 Neutrophil percentage of white cells; BRCA trans rs3733585 0.699 rs6815001 chr4:9958662 G/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs8017423 0.647 rs10132599 chr14:90815342 C/T cg04374321 chr14:90722782 PSMC1 -0.47 -11.32 -0.41 3.41e-27 Mortality in heart failure; BRCA cis rs1829883 1.000 rs1916599 chr5:98774240 C/G cg08333243 chr5:99726346 NA -0.36 -8.68 -0.32 3.19e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs514406 0.505 rs440871 chr1:53173052 C/T cg24675658 chr1:53192096 ZYG11B -0.61 -14.2 -0.49 5.94e-40 Monocyte count; BRCA cis rs7584330 0.554 rs6740722 chr2:238393288 T/C cg08992911 chr2:238395768 MLPH 0.6 10.35 0.38 2.61e-23 Prostate cancer; BRCA trans rs2197308 0.728 rs7304305 chr12:37932990 T/C cg06521331 chr12:34319734 NA 0.46 8.91 0.33 5.31e-18 Morning vs. evening chronotype; BRCA cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg26384229 chr12:38710491 ALG10B -0.55 -13.64 -0.47 2.39e-37 Morning vs. evening chronotype; BRCA cis rs7582180 0.681 rs6754176 chr2:100995691 C/T cg14675211 chr2:100938903 LONRF2 0.44 9.65 0.36 1.17e-20 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg03188948 chr7:1209495 NA 0.61 12.06 0.43 2.62e-30 Longevity;Endometriosis; BRCA cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -10.98 -0.4 7.88e-26 IgG glycosylation; BRCA cis rs1018836 0.923 rs4735230 chr8:91574184 G/C cg16814680 chr8:91681699 NA -0.64 -14.31 -0.49 1.62e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs8114671 0.839 rs6142290 chr20:33654672 A/C cg24642439 chr20:33292090 TP53INP2 -0.42 -8.52 -0.32 1.12e-16 Height; BRCA cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg01017244 chr2:74357527 NA 0.56 13.2 0.46 2.49e-35 Gestational age at birth (maternal effect); BRCA trans rs9944715 0.954 rs7228365 chr18:43817832 A/G cg01718231 chr17:29326311 RNF135 -0.46 -9.08 -0.34 1.34e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg18876405 chr7:65276391 NA 0.6 15.14 0.51 1.7e-44 Aortic root size; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg25036284 chr2:26402008 FAM59B -0.87 -14.49 -0.5 2.47e-41 Gut microbiome composition (summer); BRCA cis rs9788682 1.000 rs9788682 chr15:78802586 A/G cg24631222 chr15:78858424 CHRNA5 -0.57 -11.6 -0.42 2.23e-28 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs250677 0.687 rs250667 chr5:148455134 A/G cg23229984 chr5:148520753 ABLIM3 -0.37 -9.05 -0.34 1.66e-18 Breast cancer; BRCA cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg11262906 chr1:85462892 MCOLN2 -0.47 -8.78 -0.33 1.45e-17 Serum sulfate level; BRCA trans rs459571 0.959 rs465535 chr9:136910905 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -14.6 -0.5 7.25e-42 Platelet distribution width; BRCA cis rs597583 0.709 rs7940527 chr11:117398202 C/G cg27161313 chr11:117392002 DSCAML1 0.37 7.83 0.3 2.05e-14 Putamen volume; BRCA cis rs10197940 0.648 rs7587301 chr2:152347600 A/G cg19508488 chr2:152266495 RIF1 0.38 8.22 0.31 1.18e-15 Lung cancer; BRCA cis rs6442522 0.768 rs3821638 chr3:15511044 A/G cg16303742 chr3:15540471 COLQ 0.34 8.07 0.3 3.46e-15 Uric acid levels; BRCA cis rs921968 0.541 rs526897 chr2:219433597 C/T cg02176678 chr2:219576539 TTLL4 0.47 12.43 0.44 6.07e-32 Mean corpuscular hemoglobin concentration; BRCA cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg11764359 chr7:65958608 NA -0.68 -15.1 -0.51 2.92e-44 Aortic root size; BRCA trans rs3780486 0.846 rs3780487 chr9:33139237 T/C cg04842962 chr6:43655489 MRPS18A 1.12 39.23 0.84 2.61e-172 IgG glycosylation; BRCA cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg23711669 chr6:146136114 FBXO30 0.74 16.99 0.56 1.09e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.34 -0.31 4.49e-16 Colorectal cancer; BRCA cis rs7107174 0.792 rs10899488 chr11:78088754 A/G cg27205649 chr11:78285834 NARS2 -0.3 -8.26 -0.31 8.6e-16 Testicular germ cell tumor; BRCA trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg21226059 chr5:178986404 RUFY1 0.52 14.59 0.5 8.03e-42 Lung cancer; BRCA cis rs698833 0.926 rs698827 chr2:44730496 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.48 -9.95 -0.37 8.52e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs921968 0.565 rs7599945 chr2:219641528 G/T cg02176678 chr2:219576539 TTLL4 -0.41 -10.96 -0.4 9.9e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.38 -0.35 1.15e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg26647111 chr11:31128758 NA -0.45 -9.77 -0.36 4.35e-21 Red blood cell count; BRCA cis rs6912958 0.754 rs2268994 chr6:88185386 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.2 -0.31 1.31e-15 Monocyte percentage of white cells; BRCA cis rs28374715 0.532 rs316606 chr15:41772202 A/C cg18705301 chr15:41695430 NDUFAF1 -1.08 -24.9 -0.7 3.69e-96 Ulcerative colitis; BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg04944784 chr2:26401820 FAM59B 0.67 11.15 0.4 1.67e-26 Gut microbiome composition (summer); BRCA trans rs3733585 0.699 rs7437120 chr4:9967683 T/A cg26043149 chr18:55253948 FECH -0.38 -8.36 -0.31 3.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2882667 0.858 rs11949916 chr5:138396277 T/G cg04439458 chr5:138467593 SIL1 -0.43 -10.88 -0.4 2.01e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9341808 0.754 rs3805907 chr6:80973665 A/G cg08355045 chr6:80787529 NA -0.37 -9.56 -0.35 2.41e-20 Sitting height ratio; BRCA cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg20503657 chr10:835505 NA 1.3 21.68 0.65 1.53e-78 Eosinophil percentage of granulocytes; BRCA cis rs7927771 0.524 rs7943213 chr11:47715524 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.52 0.35 3.42e-20 Subjective well-being; BRCA cis rs698833 0.926 rs1067342 chr2:44622256 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.54 11.29 0.41 4.49e-27 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg23711669 chr6:146136114 FBXO30 0.73 17.21 0.56 7.78e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs7617773 0.779 rs9833309 chr3:48327450 C/T cg11946769 chr3:48343235 NME6 0.63 13.47 0.47 1.45e-36 Coronary artery disease; BRCA cis rs274567 0.501 rs581968 chr5:131710202 G/A cg24060327 chr5:131705240 SLC22A5 0.61 11.36 0.41 2.18e-27 Blood metabolite levels; BRCA cis rs9287719 0.967 rs6706542 chr2:10742491 A/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs2243480 1.000 rs437889 chr7:65509234 G/A cg18252515 chr7:66147081 NA -0.96 -13.72 -0.48 9.52e-38 Diabetic kidney disease; BRCA cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.93 24.04 0.69 1.93e-91 Birth weight; BRCA cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg15556689 chr8:8085844 FLJ10661 -0.38 -10.28 -0.38 4.74e-23 Neuroticism; BRCA cis rs3008870 1.000 rs12740884 chr1:67459855 C/A cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg23978390 chr7:1156363 C7orf50 0.41 8.18 0.31 1.5e-15 Bronchopulmonary dysplasia; BRCA cis rs1448094 0.512 rs6539927 chr12:86244486 T/C cg19622623 chr12:86230825 RASSF9 -0.34 -9.54 -0.35 2.85e-20 Major depressive disorder; BRCA cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg18404041 chr3:52824283 ITIH1 -0.28 -8.18 -0.31 1.51e-15 Electroencephalogram traits; BRCA trans rs4650994 0.544 rs4652301 chr1:178499799 T/C cg05059571 chr16:84539110 KIAA1609 -0.57 -12.59 -0.45 1.2e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6901250 1.000 rs615199 chr6:117113653 T/C cg12892004 chr6:117198278 RFX6 0.49 11.14 0.4 1.83e-26 C-reactive protein levels; BRCA trans rs7618501 0.633 rs3774733 chr3:50037123 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.33 9.09 0.34 1.19e-18 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg15704280 chr7:45808275 SEPT13 -0.49 -9.64 -0.36 1.29e-20 HDL cholesterol; BRCA cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg03433033 chr1:76189801 ACADM 0.75 17.32 0.57 2.23e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7617773 0.780 rs34589064 chr3:48339549 G/A cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.53 8.42 0.32 2.57e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs17685 0.712 rs10952842 chr7:75780413 G/A cg19862616 chr7:65841803 NCRNA00174 0.82 26.58 0.72 2.01e-105 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg12927641 chr6:109611667 NA -0.38 -9.61 -0.36 1.63e-20 Reticulocyte fraction of red cells; BRCA trans rs3749237 0.964 rs13084243 chr3:49821878 G/C cg21659725 chr3:3221576 CRBN 0.49 11.06 0.4 3.9e-26 Resting heart rate; BRCA cis rs6831352 0.734 rs12502237 chr4:100015675 G/A cg13256891 chr4:100009986 ADH5 0.52 10.7 0.39 1.07e-24 Alcohol dependence; BRCA cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.84 -0.3 1.86e-14 Aortic root size; BRCA trans rs9291683 0.585 rs12648479 chr4:10104571 G/A cg26043149 chr18:55253948 FECH -0.39 -8.66 -0.32 3.89e-17 Bone mineral density; BRCA cis rs3768617 0.510 rs3768618 chr1:183092491 C/A ch.1.3577855R chr1:183094577 LAMC1 0.66 17.66 0.57 3.67e-57 Fuchs's corneal dystrophy; BRCA cis rs2404618 0.504 rs2906567 chr8:1494118 C/T cg13402656 chr8:1511478 DLGAP2 -0.59 -14.12 -0.49 1.28e-39 Lung cancer; BRCA cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg06453172 chr10:134556979 INPP5A -0.6 -11.77 -0.42 4.54e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6542838 0.641 rs6757098 chr2:99471399 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.37 -8.4 -0.32 2.78e-16 Fear of minor pain; BRCA cis rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05901451 chr6:126070800 HEY2 -0.56 -14.88 -0.51 3.19e-43 Brugada syndrome; BRCA cis rs75229567 0.618 rs78294090 chr12:70209959 G/T cg10114359 chr12:70132523 RAB3IP 0.84 10.43 0.38 1.29e-23 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs4803468 1.000 rs4803463 chr19:41911040 C/G cg09537434 chr19:41945824 ATP5SL -0.98 -24.22 -0.69 2.02e-92 Height; BRCA cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg05340658 chr4:99064831 C4orf37 0.66 16.1 0.54 3.26e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 1.000 rs460508 chr3:161091089 C/G cg03342759 chr3:160939853 NMD3 0.61 12.96 0.46 2.89e-34 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg21770322 chr7:97807741 LMTK2 0.42 11.14 0.4 1.88e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs12760731 0.565 rs12037925 chr1:178160268 C/T cg00404053 chr1:178313656 RASAL2 0.65 7.96 0.3 8.01e-15 Obesity-related traits; BRCA cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg14440974 chr22:39074834 NA -0.39 -9.14 -0.34 8.25e-19 Menopause (age at onset); BRCA cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg16680214 chr1:154839983 KCNN3 -0.41 -11.29 -0.41 4.48e-27 Prostate cancer; BRCA cis rs7267979 1.000 rs401166 chr20:25446308 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.22 0.31 1.17e-15 Cognitive ability; BRCA cis rs61931739 0.534 rs1352207 chr12:34036862 C/T cg06521331 chr12:34319734 NA 0.56 11.06 0.4 3.99e-26 Morning vs. evening chronotype; BRCA cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -19.27 -0.61 1.44e-65 Chronic sinus infection; BRCA cis rs16854884 0.584 rs59768870 chr3:143738366 G/A cg06585982 chr3:143692056 C3orf58 0.42 8.92 0.33 4.98e-18 Economic and political preferences (feminism/equality); BRCA cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -9.63 -0.36 1.33e-20 Developmental language disorder (linguistic errors); BRCA cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs5758511 0.680 rs5758687 chr22:42656588 A/T cg00645731 chr22:42541494 CYP2D7P1 0.5 9.61 0.36 1.66e-20 Birth weight; BRCA cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg13010199 chr12:38710504 ALG10B 0.51 9.99 0.37 6.28e-22 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs17083460 chr5:93462354 A/G cg25358565 chr5:93447407 FAM172A 1.18 19.95 0.62 3.47e-69 Diabetic retinopathy; BRCA cis rs561341 1.000 rs15654 chr17:30326360 A/C cg00745463 chr17:30367425 LRRC37B -0.54 -8.88 -0.33 6.88e-18 Hip circumference adjusted for BMI; BRCA cis rs711245 0.573 rs3770796 chr2:36799515 T/C cg01206211 chr2:36825736 FEZ2 0.44 10.64 0.39 1.94e-24 Height; BRCA trans rs877282 0.853 rs12777155 chr10:754731 G/C cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs727479 0.502 rs8029120 chr15:51504934 A/C cg19946085 chr15:51559439 CYP19A1 -0.31 -8.59 -0.32 6.53e-17 Estradiol levels; BRCA cis rs2276314 1.000 rs4799832 chr18:33559646 T/C cg19628046 chr18:33552617 C18orf21 0.58 11.83 0.42 2.55e-29 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs3806843 1.000 rs1476768 chr5:140173597 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.82e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs11887277 0.868 rs6717682 chr2:27069211 A/G cg08802533 chr2:27073253 DPYSL5 -0.29 -7.82 -0.3 2.16e-14 Obesity-related traits; BRCA cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg04455712 chr21:45112962 RRP1B 0.39 10.17 0.37 1.25e-22 Mean corpuscular volume; BRCA trans rs804280 0.509 rs12719915 chr8:11786255 A/G cg15556689 chr8:8085844 FLJ10661 -0.35 -9.15 -0.34 7.6e-19 Myopia (pathological); BRCA cis rs7247513 0.964 rs8100964 chr19:12720631 C/T cg01871581 chr19:12707946 ZNF490 -0.68 -15.73 -0.53 2.21e-47 Bipolar disorder; BRCA cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg02544614 chr20:61657117 NA 0.29 8.12 0.31 2.36e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs4631830 0.540 rs2843562 chr10:51496796 A/G cg20129853 chr10:51489980 NA 0.33 8.92 0.33 4.78e-18 Prostate-specific antigen levels; BRCA trans rs1997103 1.000 rs4948012 chr7:55412578 A/C cg20935933 chr6:143382018 AIG1 0.6 11.57 0.42 3.18e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10754283 0.967 rs6428562 chr1:90102665 G/A cg21401794 chr1:90099060 LRRC8C 0.46 11.11 0.4 2.33e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg09184832 chr6:79620586 NA 0.52 11.16 0.4 1.57e-26 Intelligence (multi-trait analysis); BRCA cis rs6700896 0.931 rs59508186 chr1:66107881 C/A cg04111102 chr1:66153794 NA 0.33 8.11 0.31 2.58e-15 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs250677 0.522 rs10038913 chr5:148354224 A/G cg18129178 chr5:148520854 ABLIM3 0.53 10.07 0.37 2.99e-22 Breast cancer; BRCA trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg16606324 chr3:10149918 C3orf24 0.54 10.94 0.4 1.18e-25 Alzheimer's disease; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg11814155 chr7:99998594 ZCWPW1 0.49 8.74 0.33 2.06e-17 Platelet count; BRCA cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg26031613 chr14:104095156 KLC1 -0.63 -13.94 -0.48 9.44e-39 Intelligence (multi-trait analysis); BRCA trans rs1941687 0.524 rs6507062 chr18:31374197 G/C cg15819921 chr19:927150 ARID3A -0.48 -9.4 -0.35 9.38e-20 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg00983440 chr10:79422392 NA -0.54 -10.24 -0.38 7.11e-23 Bone mineral density; BRCA cis rs778371 0.676 rs17164 chr2:233593499 C/T cg08000102 chr2:233561755 GIGYF2 0.77 16.99 0.56 1.11e-53 Schizophrenia; BRCA cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg21518248 chr2:162101506 NA 0.53 11.28 0.41 5.07e-27 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg23583168 chr7:148888333 NA -0.83 -18.87 -0.6 1.94e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7781557 1.000 rs2041094 chr7:102495434 C/T cg18108683 chr7:102477205 FBXL13 -0.44 -8.08 -0.3 3.14e-15 Colorectal adenoma (advanced); BRCA cis rs3768617 0.528 rs4651144 chr1:183097421 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.09 0.56 3.2e-54 Fuchs's corneal dystrophy; BRCA cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.62 -15.26 -0.52 4.84e-45 Colorectal cancer; BRCA cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg25173405 chr17:45401733 C17orf57 0.5 10.13 0.37 1.88e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.49e-34 Alzheimer's disease (late onset); BRCA cis rs2120243 0.967 rs7648322 chr3:157143684 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.4 8.88 0.33 6.56e-18 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs11997175 1.000 rs7464996 chr8:33770925 G/T ch.8.33884649F chr8:33765107 NA 0.46 11.58 0.42 2.84e-28 Body mass index; BRCA cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg24531977 chr5:56204891 C5orf35 0.7 15.6 0.53 1.01e-46 Initial pursuit acceleration; BRCA cis rs9790314 1.000 rs1382428 chr3:161032386 A/C cg03342759 chr3:160939853 NMD3 -0.64 -13.57 -0.47 4.61e-37 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26314531 chr2:26401878 FAM59B -0.66 -11.27 -0.41 5.28e-27 Gut microbiome composition (summer); BRCA cis rs4689388 0.926 rs4688986 chr4:6285797 C/A cg25554036 chr4:6271136 WFS1 0.4 9.55 0.35 2.73e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.68 0.39 1.35e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs17685 0.664 rs9801113 chr7:75792031 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4853036 0.951 rs6710444 chr2:70120632 G/A cg02498382 chr2:70120550 SNRNP27 -0.54 -10.79 -0.39 4.9e-25 Colorectal or endometrial cancer; BRCA trans rs11992162 0.613 rs56094399 chr8:11797470 G/A cg15556689 chr8:8085844 FLJ10661 -0.34 -8.8 -0.33 1.31e-17 Monocyte count; BRCA cis rs887829 0.569 rs6711351 chr2:234634916 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.93 -0.33 4.64e-18 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs2463822 0.925 rs17157227 chr11:62169772 A/G cg06239285 chr11:62104954 ASRGL1 0.62 8.79 0.33 1.34e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs9400271 0.632 rs9487020 chr6:109587672 A/G cg01475377 chr6:109611718 NA -0.44 -10.49 -0.38 7.17e-24 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs9837602 0.592 rs1606481 chr3:99427552 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.44 -8.38 -0.31 3.41e-16 Breast cancer; BRCA trans rs7819412 0.595 rs2409712 chr8:10986837 A/C cg06636001 chr8:8085503 FLJ10661 -0.46 -9.44 -0.35 6.83e-20 Triglycerides; BRCA cis rs2276314 0.553 rs12964535 chr18:33611691 A/C cg05985134 chr18:33552581 C18orf21 -0.42 -7.96 -0.3 8.15e-15 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4233802 1.000 rs4366927 chr2:151138525 T/C cg25300694 chr2:151184358 NA 0.76 8.12 0.31 2.34e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs6782228 0.527 rs2712371 chr3:128346214 G/A cg16766828 chr3:128327626 NA -0.42 -9.49 -0.35 4.35e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7833986 1.000 rs34952804 chr8:57097399 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.22 0.31 1.14e-15 Height; BRCA cis rs1941023 0.584 rs10750937 chr11:60172087 C/T cg08716584 chr11:60157161 MS4A7 -0.42 -9.73 -0.36 5.75e-21 Congenital heart disease (maternal effect); BRCA cis rs933688 1.000 rs6862125 chr5:90724598 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.95 21.66 0.65 1.92e-78 Smoking behavior; BRCA trans rs9291683 0.507 rs6849273 chr4:10021595 C/T cg26043149 chr18:55253948 FECH 0.36 7.93 0.3 9.56e-15 Bone mineral density; BRCA cis rs4319547 0.774 rs10773394 chr12:123124778 C/A cg23029597 chr12:123009494 RSRC2 -0.38 -7.89 -0.3 1.29e-14 Body mass index; BRCA cis rs4561483 0.815 rs7198817 chr16:11945778 C/A cg08843971 chr16:11963173 GSPT1 0.49 10.84 0.39 2.95e-25 Testicular germ cell tumor; BRCA cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg05283184 chr6:79620031 NA -0.43 -11.12 -0.4 2.29e-26 Intelligence (multi-trait analysis); BRCA cis rs250677 0.687 rs250667 chr5:148455134 A/G cg12140854 chr5:148520817 ABLIM3 0.45 9.48 0.35 4.98e-20 Breast cancer; BRCA cis rs514406 0.929 rs515857 chr1:53336859 A/G cg16325326 chr1:53192061 ZYG11B 0.64 14.65 0.5 4.11e-42 Monocyte count; BRCA cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.33e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg05340658 chr4:99064831 C4orf37 0.59 12.76 0.45 2.28e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg13628971 chr7:2884303 GNA12 0.57 12.5 0.44 3.08e-32 Height; BRCA cis rs11252926 0.931 rs12355162 chr10:563472 G/A cg18196295 chr10:418757 DIP2C -0.48 -9.86 -0.36 1.91e-21 Psychosis in Alzheimer's disease; BRCA cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs6087990 0.842 rs4911105 chr20:31330413 G/A cg13636640 chr20:31349939 DNMT3B 0.71 21.31 0.64 1.55e-76 Ulcerative colitis; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg09436375 chr6:42928200 GNMT -0.28 -10.54 -0.38 4.63e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg03146154 chr1:46216737 IPP 0.5 10.93 0.4 1.28e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg18132916 chr6:79620363 NA -0.39 -7.99 -0.3 6.22e-15 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.566 rs7135104 chr12:39411086 C/T cg26384229 chr12:38710491 ALG10B 0.37 8.22 0.31 1.1e-15 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs9329221 0.736 rs11249999 chr8:10251265 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -10.28 -0.38 4.68e-23 Neuroticism; BRCA cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs754466 0.580 rs12357670 chr10:79558180 T/C cg17075019 chr10:79541650 NA -0.83 -20.69 -0.63 3.62e-73 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.32 0.41 3.45e-27 Intelligence (multi-trait analysis); BRCA cis rs832540 0.866 rs832579 chr5:56164943 A/G cg24531977 chr5:56204891 C5orf35 -0.41 -8.37 -0.31 3.57e-16 Coronary artery disease; BRCA trans rs61931739 0.534 rs11052973 chr12:34029708 A/G cg26384229 chr12:38710491 ALG10B 0.68 14.43 0.5 4.38e-41 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.78 0.39 5.36e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs9296092 0.538 rs9461887 chr6:33526827 C/T cg13560919 chr6:33536144 NA -0.85 -17.98 -0.58 8.28e-59 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg11584989 chr19:19387371 SF4 0.66 14.37 0.49 9.05e-41 Bipolar disorder; BRCA cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.42 0.41 1.25e-27 Homoarginine levels; BRCA cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg23711669 chr6:146136114 FBXO30 0.68 13.55 0.47 5.76e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs2832077 0.883 rs11702413 chr21:30188395 A/C cg24692254 chr21:30365293 RNF160 -0.45 -7.96 -0.3 8.04e-15 Cognitive test performance; BRCA trans rs2832077 0.527 rs1048546 chr21:30244877 G/T cg14791747 chr16:20752902 THUMPD1 0.4 12.25 0.44 3.99e-31 Cognitive test performance; BRCA cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg11057378 chr10:81107060 PPIF 0.42 9.75 0.36 5.07e-21 Height; BRCA cis rs6750795 0.746 rs2916579 chr2:232421159 A/G cg19187155 chr2:232395269 NMUR1 0.81 21.1 0.64 2.23e-75 Height; BRCA cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg15017067 chr4:17643749 FAM184B 0.31 9.45 0.35 6.05e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7647973 0.626 rs1463728 chr3:49647404 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.03 -0.3 4.65e-15 Menarche (age at onset); BRCA cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg20476274 chr7:133979776 SLC35B4 0.66 19.16 0.6 5.54e-65 Mean platelet volume; BRCA cis rs6815814 0.808 rs4833093 chr4:38789740 G/T cg06935464 chr4:38784597 TLR10 0.5 10.02 0.37 4.81e-22 Breast cancer; BRCA cis rs6546550 0.935 rs60207187 chr2:70093910 G/A cg02498382 chr2:70120550 SNRNP27 -0.43 -9.4 -0.35 9.49e-20 Prevalent atrial fibrillation; BRCA cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11644478 chr21:40555479 PSMG1 0.73 14.49 0.5 2.4e-41 Cognitive function; BRCA cis rs9325144 0.505 rs6582691 chr12:38806894 T/C cg13010199 chr12:38710504 ALG10B -0.42 -10.16 -0.37 1.43e-22 Morning vs. evening chronotype; BRCA cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg24110177 chr3:50126178 RBM5 0.53 15.83 0.53 7.31e-48 Body mass index; BRCA cis rs7568458 0.684 rs6731700 chr2:85760991 C/G cg02493740 chr2:85810744 VAMP5 -0.53 -10.98 -0.4 8.43e-26 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs36051895 0.559 rs7850228 chr9:5210671 C/G cg02405213 chr9:5042618 JAK2 0.44 8.38 0.31 3.26e-16 Pediatric autoimmune diseases; BRCA cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.95 -0.3 8.34e-15 Bipolar disorder; BRCA cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg11663144 chr21:46675770 NA -0.61 -14.24 -0.49 3.81e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11585357 0.895 rs72633806 chr1:17617943 A/G cg19159961 chr1:17633534 PADI4 0.58 9.06 0.34 1.56e-18 Hair shape; BRCA cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg19077165 chr18:44547161 KATNAL2 -0.56 -12.24 -0.44 4.24e-31 Personality dimensions; BRCA cis rs7520050 0.801 rs6703960 chr1:46232723 C/T cg24296786 chr1:45957014 TESK2 0.45 10.35 0.38 2.6e-23 Red blood cell count;Reticulocyte count; BRCA cis rs2370759 1.000 rs11599044 chr10:32615445 A/G cg18270830 chr10:32634957 EPC1 0.57 9.92 0.37 1.1e-21 Sexual dysfunction (female); BRCA cis rs2742234 0.915 rs2742233 chr10:43610558 C/T cg15436174 chr10:43711423 RASGEF1A -0.43 -9.16 -0.34 6.83e-19 Hirschsprung disease; BRCA cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.67e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs3739998 0.686 rs2505084 chr10:30335520 C/T cg00730780 chr10:30316187 KIAA1462 -0.44 -9.58 -0.35 2.04e-20 Coronary heart disease; BRCA cis rs2625529 0.824 rs4411469 chr15:72421689 A/G cg16672083 chr15:72433130 SENP8 -0.85 -17.68 -0.57 3.19e-57 Red blood cell count; BRCA cis rs6570726 0.620 rs12201226 chr6:145913419 A/T cg13319975 chr6:146136371 FBXO30 -0.59 -13.43 -0.47 2.09e-36 Lobe attachment (rater-scored or self-reported); BRCA trans rs3858145 0.588 rs7081284 chr10:70044792 C/G cg04882175 chr6:131122610 NA -0.34 -7.83 -0.3 1.99e-14 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs9463078 0.526 rs9472337 chr6:44711576 C/A cg25276700 chr6:44698697 NA 0.36 8.18 0.31 1.56e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6433857 0.505 rs1542036 chr2:181350009 A/C cg23363182 chr2:181467187 NA -0.37 -7.87 -0.3 1.57e-14 Body mass index; BRCA cis rs752010 0.967 rs4083593 chr1:42099583 A/G cg06885757 chr1:42089581 HIVEP3 0.25 8.77 0.33 1.55e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg13319975 chr6:146136371 FBXO30 0.42 9.26 0.34 3e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4253311 0.520 rs10000459 chr4:187124459 A/C cg24794857 chr4:187113578 CYP4V2 0.36 7.94 0.3 8.97e-15 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; BRCA cis rs6121246 0.821 rs3181073 chr20:30307199 A/C cg13852791 chr20:30311386 BCL2L1 -0.84 -16.66 -0.55 5.05e-52 Mean corpuscular hemoglobin; BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg18765753 chr7:1198926 ZFAND2A -0.4 -8.0 -0.3 5.85e-15 Bronchopulmonary dysplasia; BRCA cis rs4589502 1.000 rs4589502 chr15:67155069 C/T cg09911534 chr15:67153556 NA -0.67 -11.21 -0.41 9.9e-27 Lung cancer (smoking interaction); BRCA cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg14019146 chr3:50243930 SLC38A3 -0.57 -11.9 -0.43 1.24e-29 Intelligence (multi-trait analysis); BRCA cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg26408565 chr15:76604113 ETFA -0.49 -10.38 -0.38 2.01e-23 Blood metabolite levels; BRCA cis rs11098499 1.000 rs35643470 chr4:120184948 T/C cg09307838 chr4:120376055 NA 0.62 12.76 0.45 2.16e-33 Corneal astigmatism; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.17 -0.34 6.4e-19 Menopause (age at onset); BRCA cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.25e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03576123 chr11:487126 PTDSS2 1.16 17.83 0.58 4.99e-58 Body mass index; BRCA cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg06627628 chr2:24431161 ITSN2 -0.54 -8.82 -0.33 1.08e-17 Lymphocyte counts; BRCA cis rs2576037 0.901 rs2571021 chr18:44583498 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.39 7.97 0.3 7.41e-15 Personality dimensions; BRCA cis rs7824557 1.000 rs2736371 chr8:11105529 A/G cg21775007 chr8:11205619 TDH -0.54 -10.59 -0.39 2.87e-24 Retinal vascular caliber; BRCA cis rs7394190 0.748 rs60212594 chr10:75414344 G/C cg07699608 chr10:75541558 CHCHD1 0.56 8.73 0.33 2.21e-17 Incident atrial fibrillation; BRCA cis rs9649213 0.586 rs11768599 chr7:97974555 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.59 -15.88 -0.53 4.34e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs2239547 0.657 rs12488303 chr3:52862003 G/A cg11645453 chr3:52864694 ITIH4 0.49 11.98 0.43 5.43e-30 Schizophrenia; BRCA cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg26384229 chr12:38710491 ALG10B 0.74 17.53 0.57 1.85e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg16145915 chr7:1198662 ZFAND2A -0.63 -14.76 -0.5 1.19e-42 Longevity;Endometriosis; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg03709012 chr19:19516395 GATAD2A 0.81 18.83 0.6 3.08e-63 Tonsillectomy; BRCA cis rs425277 1.000 rs196128 chr1:2078444 T/G cg00981070 chr1:2046702 PRKCZ 0.31 8.25 0.31 9.06e-16 Height; BRCA cis rs6430585 0.591 rs12466487 chr2:136407078 C/T cg07169764 chr2:136633963 MCM6 -1.12 -19.58 -0.61 3.21e-67 Corneal structure; BRCA cis rs9814567 1.000 rs62271515 chr3:134300507 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11229555 0.645 rs12226725 chr11:58246332 G/A cg15696309 chr11:58395628 NA -0.51 -10.71 -0.39 1.03e-24 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7903847 0.642 rs11817852 chr10:99158426 C/T cg20016023 chr10:99160130 RRP12 -0.26 -8.41 -0.32 2.58e-16 Granulocyte percentage of myeloid white cells; BRCA trans rs17685 0.712 rs4732578 chr7:75721532 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 27.76 0.74 6.66e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4780401 0.609 rs4781142 chr16:11808806 T/C cg01061890 chr16:11836724 TXNDC11 -0.55 -13.08 -0.46 8.08e-35 Rheumatoid arthritis; BRCA cis rs9880211 0.948 rs13326151 chr3:136261744 C/T cg21827317 chr3:136751795 NA -0.44 -7.97 -0.3 7.13e-15 Body mass index;Height; BRCA trans rs262150 0.842 rs2657398 chr7:158784911 T/C cg21167628 chr1:45308625 PTCH2 -0.31 -7.85 -0.3 1.78e-14 Facial morphology (factor 20); BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg22907277 chr7:1156413 C7orf50 0.59 9.19 0.34 5.33e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1707322 0.963 rs34907901 chr1:46405214 T/G cg06784218 chr1:46089804 CCDC17 0.44 10.29 0.38 4.51e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg23992470 chr4:843637 GAK 0.54 8.28 0.31 7.3e-16 Intelligence (multi-trait analysis); BRCA cis rs1475718 0.526 rs7854734 chr9:137122410 C/G cg21243944 chr9:137118148 NA 0.34 9.25 0.34 3.37e-19 Immature fraction of reticulocytes;Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs365132 1.000 rs2055619 chr5:176415964 A/G cg16309518 chr5:176445507 NA -0.52 -13.35 -0.47 4.77e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.43 0.32 2.35e-16 Rheumatoid arthritis; BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg03709012 chr19:19516395 GATAD2A 0.71 15.15 0.51 1.54e-44 Tonsillectomy; BRCA cis rs36051895 0.664 rs3780371 chr9:5095191 T/A cg02405213 chr9:5042618 JAK2 -0.5 -9.09 -0.34 1.24e-18 Pediatric autoimmune diseases; BRCA cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg07606381 chr6:8435919 SLC35B3 0.66 14.57 0.5 9.5e-42 Motion sickness; BRCA cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.17 -0.43 8.89e-31 Bipolar disorder; BRCA cis rs9986765 1.000 rs4565384 chr7:142811564 C/A cg15652212 chr7:142981776 TMEM139 0.57 9.35 0.35 1.44e-19 Cancer;Dermatomyositis; BRCA cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22857025 chr5:266934 NA -1.1 -19.12 -0.6 8.29e-65 Breast cancer; BRCA cis rs9287719 0.601 rs6755281 chr2:10769855 T/C cg00105475 chr2:10696890 NA 0.47 10.28 0.38 4.96e-23 Prostate cancer; BRCA cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg26384229 chr12:38710491 ALG10B 0.71 16.45 0.55 5.52e-51 Drug-induced liver injury (flucloxacillin); BRCA cis rs7927771 1.000 rs7105282 chr11:47805614 C/A cg18512352 chr11:47633146 NA -0.34 -8.19 -0.31 1.38e-15 Subjective well-being; BRCA cis rs35146811 0.695 rs1618851 chr7:99810643 T/G cg13334819 chr7:99746414 C7orf59 0.34 8.05 0.3 4.16e-15 Coronary artery disease; BRCA cis rs28493229 0.522 rs2287692 chr19:41289756 G/A cg21869046 chr19:41225005 ITPKC 0.4 9.81 0.36 2.93e-21 Kawasaki disease; BRCA cis rs66530629 1.000 rs1316829 chr1:25051225 C/T cg01905478 chr1:25040257 NA 0.37 8.34 0.31 4.52e-16 Plateletcrit; BRCA cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg23029597 chr12:123009494 RSRC2 0.62 12.14 0.43 1.2e-30 Body mass index; BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg22920501 chr2:26401640 FAM59B -0.8 -13.02 -0.46 1.55e-34 Gut microbiome composition (summer); BRCA cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.58 0.32 7.01e-17 Rheumatoid arthritis; BRCA cis rs490234 0.702 rs13284551 chr9:128411969 C/T cg14078157 chr9:128172775 NA -0.51 -11.3 -0.41 3.88e-27 Mean arterial pressure; BRCA cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg04166393 chr7:2884313 GNA12 -0.54 -11.02 -0.4 5.56e-26 Height; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -11.97 -0.43 6.35e-30 Alzheimer's disease; BRCA cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg05985134 chr18:33552581 C18orf21 0.64 12.12 0.43 1.41e-30 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg08508325 chr11:3079039 CARS -0.43 -15.61 -0.53 8.94e-47 Longevity; BRCA cis rs919433 0.647 rs6741205 chr2:198525997 G/C cg00792783 chr2:198669748 PLCL1 0.39 9.03 0.34 2.08e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg05340658 chr4:99064831 C4orf37 0.6 13.01 0.46 1.7e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg11530693 chr1:120165357 ZNF697 0.62 14.94 0.51 1.68e-43 Systemic lupus erythematosus; BRCA cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg17892150 chr10:133769511 PPP2R2D -0.72 -15.08 -0.51 3.63e-44 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9287719 0.967 rs6432120 chr2:10753771 C/T cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg15595755 chr5:1867978 NA 0.35 8.38 0.31 3.48e-16 Cardiovascular disease risk factors; BRCA cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.28 0.44 2.88e-31 Prostate cancer (SNP x SNP interaction); BRCA trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg03929089 chr4:120376271 NA 0.88 22.44 0.66 1.1e-82 Height; BRCA cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg06115741 chr20:33292138 TP53INP2 0.5 11.11 0.4 2.41e-26 Coronary artery disease; BRCA cis rs9900497 0.569 rs2072327 chr17:19651482 G/T cg22552966 chr17:19620595 SLC47A2 -0.38 -10.72 -0.39 8.79e-25 Response to paliperidone in schizophrenia (CGI-S score); BRCA trans rs877282 1.000 rs11253361 chr10:770387 T/C cg22713356 chr15:30763199 NA 1.11 21.73 0.65 8.61e-79 Uric acid levels; BRCA cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg26384229 chr12:38710491 ALG10B 0.54 13.73 0.48 9.25e-38 Morning vs. evening chronotype; BRCA cis rs4363385 0.747 rs4240868 chr1:152981599 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.79e-16 Inflammatory skin disease; BRCA cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -18.1 -0.58 2.1e-59 Extrinsic epigenetic age acceleration; BRCA cis rs10751667 0.666 rs4074231 chr11:978219 G/C ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 14.17 0.49 7.92e-40 Colorectal cancer; BRCA cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08109568 chr15:31115862 NA -0.44 -10.28 -0.38 4.62e-23 Huntington's disease progression; BRCA cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg08999081 chr20:33150536 PIGU -0.35 -9.12 -0.34 9.92e-19 Coronary artery disease; BRCA cis rs1555322 0.530 rs2275275 chr20:33872311 G/C cg03689076 chr20:33865952 NA 0.44 8.08 0.3 3.26e-15 Attention deficit hyperactivity disorder; BRCA cis rs9304742 0.962 rs12461796 chr19:53455088 T/A cg09915433 chr19:53449742 NA -0.74 -17.03 -0.56 6.96e-54 Psoriasis; BRCA cis rs4363385 0.720 rs1611755 chr1:152956420 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.47 -0.32 1.73e-16 Inflammatory skin disease; BRCA cis rs1065656 0.619 rs2492883 chr16:1902105 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.38 -8.13 -0.31 2.23e-15 Insulin-like growth factors; BRCA cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg02659138 chr7:134003124 SLC35B4 0.35 10.85 0.39 2.84e-25 Mean platelet volume; BRCA cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA trans rs7647973 0.626 rs11720705 chr3:49753788 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -8.52 -0.32 1.12e-16 Menarche (age at onset); BRCA cis rs6750047 0.678 rs4670811 chr2:38277376 C/A cg07380506 chr2:38303506 CYP1B1 0.42 9.34 0.35 1.61e-19 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7246657 0.943 rs12981532 chr19:37889280 G/A cg23950597 chr19:37808831 NA -0.75 -13.01 -0.46 1.65e-34 Coronary artery calcification; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg25036284 chr2:26402008 FAM59B -0.64 -11.09 -0.4 2.83e-26 Gut microbiome composition (summer); BRCA cis rs8180040 0.966 rs11705957 chr3:47443262 T/G cg27129171 chr3:47204927 SETD2 -0.69 -15.98 -0.53 1.3e-48 Colorectal cancer; BRCA cis rs9467773 0.869 rs1796520 chr6:26410800 C/T cg09904177 chr6:26538194 HMGN4 -0.46 -13.15 -0.46 4.1e-35 Intelligence (multi-trait analysis); BRCA cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.83 18.09 0.58 2.32e-59 Smoking behavior; BRCA trans rs62103177 0.810 rs62096746 chr18:77619556 T/A cg05926928 chr17:57297772 GDPD1 1.2 16.06 0.54 5.5e-49 Opioid sensitivity; BRCA cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.17 -0.4 1.33e-26 Schizophrenia; BRCA cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg15103426 chr22:29168792 CCDC117 0.54 12.61 0.45 1.02e-32 Lymphocyte counts; BRCA cis rs9560113 1.000 rs9555806 chr13:112179954 G/A cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg21395723 chr22:39101663 GTPBP1 0.38 8.32 0.31 5.17e-16 Menopause (age at onset); BRCA cis rs4727027 0.899 rs4727025 chr7:148862863 A/G cg23583168 chr7:148888333 NA -0.86 -20.07 -0.62 7.29e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs801193 0.613 rs2659900 chr7:66184443 G/C cg18876405 chr7:65276391 NA 0.52 12.14 0.43 1.14e-30 Aortic root size; BRCA cis rs1801251 0.778 rs2675967 chr2:233736133 C/G cg25237894 chr2:233734115 C2orf82 -0.44 -13.7 -0.48 1.17e-37 Coronary artery disease; BRCA cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.49 0.38 7.33e-24 Bladder cancer; BRCA cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg18132916 chr6:79620363 NA -0.48 -10.87 -0.4 2.27e-25 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.562 rs6058137 chr20:33475074 G/A cg24642439 chr20:33292090 TP53INP2 0.41 8.0 0.3 5.83e-15 Height; BRCA cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg10495392 chr1:46806563 NSUN4 0.46 8.46 0.32 1.82e-16 Menopause (age at onset); BRCA cis rs7301826 1.000 rs7301826 chr12:131291101 C/T cg11011512 chr12:131303247 STX2 0.42 10.88 0.4 2.03e-25 Plasma plasminogen activator levels; BRCA cis rs7927771 1.000 rs4752873 chr11:47857520 C/T cg18512352 chr11:47633146 NA -0.34 -8.1 -0.31 2.72e-15 Subjective well-being; BRCA cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg23711669 chr6:146136114 FBXO30 -0.7 -16.49 -0.55 3.76e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2904967 0.929 rs3016001 chr11:65008771 G/A cg09225861 chr11:65069680 NA -0.38 -7.86 -0.3 1.67e-14 Mean corpuscular volume; BRCA cis rs7940866 0.903 rs1433980 chr11:130870956 A/G cg12179176 chr11:130786555 SNX19 0.58 13.47 0.47 1.36e-36 Schizophrenia; BRCA cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg05283184 chr6:79620031 NA -0.44 -11.35 -0.41 2.46e-27 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg08470875 chr2:26401718 FAM59B -0.51 -8.48 -0.32 1.5e-16 Gut microbiome composition (summer); BRCA cis rs10197940 0.578 rs2432956 chr2:152287831 C/T cg19508488 chr2:152266495 RIF1 -0.41 -8.49 -0.32 1.44e-16 Lung cancer; BRCA cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg00012203 chr2:219082015 ARPC2 -0.4 -7.83 -0.3 2.1e-14 Ulcerative colitis; BRCA cis rs2712184 0.756 rs2712164 chr2:217659916 G/A cg05032264 chr2:217675019 NA -0.37 -9.07 -0.34 1.47e-18 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs11098499 0.605 rs6833140 chr4:120266822 G/A cg09307838 chr4:120376055 NA 0.59 12.97 0.46 2.47e-34 Corneal astigmatism; BRCA cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.93 20.61 0.63 9.63e-73 Smoking behavior; BRCA cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg23788917 chr6:8435910 SLC35B3 0.47 10.31 0.38 3.56e-23 Motion sickness; BRCA cis rs13095912 0.925 rs11924016 chr3:185307879 A/T cg11274856 chr3:185301563 NA 0.35 8.51 0.32 1.24e-16 Systolic blood pressure; BRCA cis rs10838687 0.736 rs11039144 chr11:47264044 G/A cg25783544 chr11:47291846 MADD 0.42 7.82 0.3 2.17e-14 Proinsulin levels; BRCA cis rs9443189 0.570 rs523465 chr6:76330434 G/C cg01950844 chr6:76311363 SENP6 0.84 13.7 0.48 1.24e-37 Prostate cancer; BRCA cis rs921968 0.565 rs3755045 chr2:219609162 T/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 6.11e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs911555 0.723 rs4906320 chr14:103876925 T/C cg12935359 chr14:103987150 CKB 0.63 14.56 0.5 1.13e-41 Intelligence (multi-trait analysis); BRCA cis rs1451375 0.617 rs2060763 chr7:50542359 G/A cg18232548 chr7:50535776 DDC -0.43 -8.93 -0.33 4.42e-18 Malaria; BRCA cis rs2882667 0.858 rs11242448 chr5:138443154 C/A cg04439458 chr5:138467593 SIL1 -0.43 -10.83 -0.39 3.27e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.54 0.57 1.58e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504073 0.647 rs4873096 chr8:49995201 A/G cg00325661 chr8:49890786 NA 0.44 12.49 0.44 3.6e-32 Blood metabolite ratios; BRCA cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg22535103 chr8:58192502 C8orf71 -0.42 -8.65 -0.32 4.24e-17 Developmental language disorder (linguistic errors); BRCA cis rs765787 0.530 rs1648285 chr15:45517505 C/G cg24006582 chr15:45444508 DUOX1 -0.54 -11.11 -0.4 2.54e-26 Uric acid levels; BRCA cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg06784218 chr1:46089804 CCDC17 -0.33 -7.99 -0.3 6.11e-15 Red blood cell count;Reticulocyte count; BRCA cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg24110177 chr3:50126178 RBM5 -0.46 -10.26 -0.38 5.66e-23 Intelligence (multi-trait analysis); BRCA cis rs2832191 0.545 rs2251381 chr21:30530692 T/G cg08807101 chr21:30365312 RNF160 0.39 8.71 0.33 2.63e-17 Dental caries; BRCA cis rs11677370 0.603 rs10178523 chr2:3854169 G/A cg17052675 chr2:3827356 NA -0.5 -12.09 -0.43 1.93e-30 Type 2 diabetes; BRCA cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg18918831 chr3:195489782 MUC4 -0.62 -9.71 -0.36 7.23e-21 Lung disease severity in cystic fibrosis; BRCA cis rs12042938 0.935 rs1417585 chr1:231803604 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.36 7.91 0.3 1.12e-14 Neuranatomic and neurocognitive phenotypes; BRCA cis rs754466 0.510 rs55893027 chr10:79588209 C/T cg17075019 chr10:79541650 NA -0.66 -16.84 -0.55 6.1e-53 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.26 -0.31 8.33e-16 Monocyte percentage of white cells; BRCA trans rs6479891 1.000 rs16918567 chr10:65294670 A/C cg14819942 chr15:35414228 NA 0.35 8.48 0.32 1.58e-16 Arthritis (juvenile idiopathic); BRCA cis rs1957429 0.520 rs72625648 chr14:65344602 A/G cg23373153 chr14:65346875 NA -0.79 -8.45 -0.32 2.04e-16 Pediatric areal bone mineral density (radius); BRCA cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg21573476 chr21:45109991 RRP1B -0.36 -9.42 -0.35 7.88e-20 Mean corpuscular volume; BRCA cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg04553112 chr3:125709451 NA -0.55 -8.43 -0.32 2.24e-16 Blood pressure (smoking interaction); BRCA trans rs11098499 1.000 rs11726229 chr4:120211580 C/T cg25214090 chr10:38739885 LOC399744 0.5 10.93 0.4 1.34e-25 Corneal astigmatism; BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg22337977 chr21:31811175 KRTAP15-1 0.33 7.96 0.3 7.95e-15 HDL cholesterol; BRCA cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18758796 chr5:131593413 PDLIM4 0.37 9.14 0.34 8.44e-19 Acylcarnitine levels; BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg11766577 chr21:47581405 C21orf56 0.49 10.64 0.39 1.83e-24 Testicular germ cell tumor; BRCA cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg18446336 chr7:2847575 GNA12 -0.34 -8.25 -0.31 9.28e-16 Height; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg13047869 chr3:10149882 C3orf24 0.57 11.64 0.42 1.5e-28 Alzheimer's disease; BRCA cis rs9650657 0.504 rs7813802 chr8:11033976 C/T cg21775007 chr8:11205619 TDH 0.39 8.26 0.31 8.18e-16 Neuroticism; BRCA cis rs2976388 0.556 rs4736323 chr8:143830359 C/T cg20862496 chr8:143823734 SLURP1 0.36 8.91 0.33 5.24e-18 Urinary tract infection frequency; BRCA cis rs9309473 1.000 rs10187192 chr2:73713500 T/C cg20560298 chr2:73613845 ALMS1 -0.5 -12.21 -0.43 5.94e-31 Metabolite levels; BRCA cis rs6005807 0.719 rs9625509 chr22:28989246 G/C cg12565055 chr22:29076175 TTC28 0.51 9.44 0.35 7.12e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg22907277 chr7:1156413 C7orf50 0.49 10.31 0.38 3.73e-23 Longevity;Endometriosis; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg20007245 chr22:24372913 LOC391322 0.64 14.49 0.5 2.43e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.48 -13.87 -0.48 1.88e-38 Total body bone mineral density; BRCA cis rs6942756 0.774 rs2566885 chr7:128917587 C/T cg02491457 chr7:128862824 NA 0.57 12.04 0.43 3.02e-30 White matter hyperintensity burden; BRCA cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.52 0.77 6.7e-127 Chronic sinus infection; BRCA trans rs911555 0.692 rs7140647 chr14:103893465 A/G cg17675199 chr6:35436792 RPL10A -0.3 -8.02 -0.3 5.05e-15 Intelligence (multi-trait analysis); BRCA cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg10523679 chr1:76189770 ACADM -0.49 -9.62 -0.36 1.49e-20 Daytime sleep phenotypes; BRCA trans rs208520 1.000 rs12193077 chr6:66989548 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.41 0.5 5.6e-41 Exhaled nitric oxide output; BRCA trans rs6951245 0.529 rs10262070 chr7:1141738 C/T cg13565492 chr6:43139072 SRF -0.89 -16.44 -0.55 6.9e-51 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg22105103 chr4:187893119 NA 0.37 11.69 0.42 9.77e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs2806561 0.929 rs2903545 chr1:23541108 C/T cg19743168 chr1:23544995 NA -0.47 -11.85 -0.42 1.93e-29 Height; BRCA trans rs45509595 0.556 rs34409918 chr6:27685348 A/G cg06606381 chr12:133084897 FBRSL1 -0.89 -8.8 -0.33 1.3e-17 Breast cancer; BRCA cis rs514406 0.708 rs514881 chr1:53336737 A/G cg16325326 chr1:53192061 ZYG11B -0.57 -12.69 -0.45 4.67e-33 Monocyte count; BRCA cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg18230493 chr5:56204884 C5orf35 0.91 17.71 0.57 2.24e-57 Initial pursuit acceleration; BRCA trans rs35110281 0.777 rs7276215 chr21:44990697 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.07 0.37 3.03e-22 Mean corpuscular volume; BRCA cis rs9486719 1.000 rs926276 chr6:96868735 C/T cg06623918 chr6:96969491 KIAA0776 0.72 14.05 0.49 2.84e-39 Migraine;Coronary artery disease; BRCA cis rs881375 0.967 rs7848332 chr9:123669496 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.53 0.32 1.09e-16 Rheumatoid arthritis; BRCA cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg01884057 chr2:25150051 NA 0.35 9.26 0.34 2.97e-19 Body mass index; BRCA cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg24812749 chr6:127587940 RNF146 0.86 20.26 0.63 7.08e-71 Breast cancer; BRCA trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21659725 chr3:3221576 CRBN -0.46 -11.67 -0.42 1.17e-28 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg16339924 chr4:17578868 LAP3 0.63 15.65 0.53 5.75e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 0.545 rs10950027 chr7:65634151 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.13 0.37 1.76e-22 Aortic root size; BRCA cis rs10411936 0.626 rs8109817 chr19:16587889 T/C cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.71 0.36 6.85e-21 White blood cell count;Multiple sclerosis; BRCA cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs17604090 0.550 rs111649163 chr7:29689176 C/T cg19413766 chr7:29689036 LOC646762 -0.6 -8.43 -0.32 2.27e-16 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs2882667 0.931 rs11955952 chr5:138329119 A/G cg04439458 chr5:138467593 SIL1 -0.33 -9.11 -0.34 1.07e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7072216 0.727 rs6584199 chr10:100169983 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs56399783 0.614 rs116929101 chr7:2760325 G/A cg19731401 chr7:2775893 GNA12 0.5 7.89 0.3 1.34e-14 Childhood ear infection; BRCA cis rs35110281 0.720 rs162380 chr21:44925283 T/C cg21573476 chr21:45109991 RRP1B 0.37 9.24 0.34 3.55e-19 Mean corpuscular volume; BRCA cis rs4642101 0.686 rs13085726 chr3:12832672 A/C cg24848339 chr3:12840334 CAND2 0.5 13.52 0.47 8.3e-37 QRS complex (12-leadsum); BRCA cis rs10197940 0.662 rs4335940 chr2:152275304 A/G cg19508488 chr2:152266495 RIF1 -0.43 -9.11 -0.34 1.05e-18 Lung cancer; BRCA cis rs243505 1.000 rs243516 chr7:148426271 T/G cg09806900 chr7:148480153 CUL1 -0.4 -8.35 -0.31 4.36e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs858239 0.600 rs10233039 chr7:23143113 G/A cg23682824 chr7:23144976 KLHL7 0.43 11.61 0.42 2.11e-28 Cerebrospinal fluid biomarker levels; BRCA cis rs6752107 1.000 rs6708373 chr2:234172846 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.54 0.42 4.13e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs483180 0.531 rs539708 chr1:120208503 G/T cg19096424 chr1:120255104 PHGDH -0.43 -9.41 -0.35 8.47e-20 Macular telangiectasia type 2; BRCA cis rs798554 0.704 rs798503 chr7:2789704 G/A cg19717773 chr7:2847554 GNA12 -0.4 -8.85 -0.33 8.78e-18 Height; BRCA cis rs41005 0.805 rs10469618 chr2:8117622 C/T cg03155496 chr2:8117019 LOC339788 -0.59 -16.59 -0.55 1.13e-51 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg17888033 chr8:143858414 LYNX1 -0.41 -9.65 -0.36 1.21e-20 Urinary tract infection frequency; BRCA cis rs8180040 0.620 rs6767907 chr3:47162661 C/T cg27129171 chr3:47204927 SETD2 -0.73 -18.04 -0.58 4.36e-59 Colorectal cancer; BRCA cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg10523679 chr1:76189770 ACADM 0.77 15.94 0.53 2.09e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11105298 0.891 rs3825330 chr12:89933710 C/T cg00757033 chr12:89920650 WDR51B 0.52 10.52 0.38 5.84e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs754466 1.000 rs12220311 chr10:79681507 C/T cg17075019 chr10:79541650 NA -0.68 -12.85 -0.45 9.14e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg03808351 chr9:123631620 PHF19 0.4 7.85 0.3 1.7e-14 Rheumatoid arthritis; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 20.15 0.62 2.88e-70 Platelet count; BRCA cis rs6763687 0.828 rs8179884 chr3:171781535 C/G cg16233210 chr3:171778391 FNDC3B 0.39 8.54 0.32 9.61e-17 Red cell distribution width; BRCA cis rs10174077 0.874 rs10186656 chr2:152475938 T/G cg19508488 chr2:152266495 RIF1 0.42 8.76 0.33 1.8e-17 Squamous cell lung carcinoma; BRCA cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg06784218 chr1:46089804 CCDC17 0.46 10.98 0.4 8.22e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17092148 1.000 rs6060025 chr20:33326876 A/G cg16810054 chr20:33298113 TP53INP2 -0.49 -11.24 -0.41 6.88e-27 Neuroticism; BRCA cis rs9768139 0.634 rs56389048 chr7:158121368 T/A cg24154853 chr7:158122151 PTPRN2 0.35 8.11 0.31 2.66e-15 Calcium levels; BRCA cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg20701182 chr2:24300061 SF3B14 0.59 9.08 0.34 1.3e-18 Lymphocyte counts; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.42 -9.96 -0.37 8.16e-22 Lymphocyte counts; BRCA trans rs3780486 0.505 rs10813959 chr9:33166234 C/T cg20290983 chr6:43655470 MRPS18A -0.8 -20.63 -0.63 7.83e-73 IgG glycosylation; BRCA cis rs36051895 0.632 rs10815164 chr9:5131312 T/A cg02405213 chr9:5042618 JAK2 -0.49 -8.89 -0.33 6.14e-18 Pediatric autoimmune diseases; BRCA cis rs2354432 0.943 rs6660219 chr1:146691404 A/T cg25205988 chr1:146714368 CHD1L 0.94 15.76 0.53 1.59e-47 Mitochondrial DNA levels; BRCA trans rs8073060 0.586 rs225264 chr17:33961335 A/G cg19694781 chr19:47549865 TMEM160 -1.05 -21.13 -0.64 1.41e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs12210905 0.688 rs114188783 chr6:27449604 T/C cg08851530 chr6:28072375 NA 0.82 7.99 0.3 6.52e-15 Hip circumference adjusted for BMI; BRCA cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg26248373 chr2:1572462 NA -0.62 -14.37 -0.49 8.48e-41 IgG glycosylation; BRCA cis rs367615 0.659 rs13435970 chr5:108884660 C/T cg17395555 chr5:108820864 NA 0.34 8.98 0.33 2.91e-18 Colorectal cancer (SNP x SNP interaction); BRCA cis rs12497850 1.000 rs12493578 chr3:48730116 C/T cg07636037 chr3:49044803 WDR6 -0.9 -23.13 -0.68 1.89e-86 Parkinson's disease; BRCA cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08280861 chr8:58055591 NA 0.44 9.62 0.36 1.5e-20 Developmental language disorder (linguistic errors); BRCA cis rs72627509 0.951 rs17087335 chr4:57838583 G/T cg26694713 chr4:57773883 REST 0.47 8.64 0.32 4.4e-17 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26314531 chr2:26401878 FAM59B -0.9 -15.71 -0.53 2.96e-47 Gut microbiome composition (summer); BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg00106254 chr7:1943704 MAD1L1 0.35 9.63 0.36 1.41e-20 Bipolar disorder and schizophrenia; BRCA cis rs7119038 0.818 rs10892287 chr11:118642999 C/T cg19308663 chr11:118741387 NA -0.4 -9.18 -0.34 5.9e-19 Sjögren's syndrome; BRCA trans rs61931739 1.000 rs11052967 chr12:34020030 T/G cg26384229 chr12:38710491 ALG10B -0.42 -9.43 -0.35 7.6e-20 Morning vs. evening chronotype; BRCA cis rs208520 0.690 rs10944872 chr6:66708239 T/G cg07460842 chr6:66804631 NA 0.92 18.44 0.59 3.16e-61 Exhaled nitric oxide output; BRCA cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg06808227 chr14:105710500 BRF1 0.8 15.88 0.53 4.2e-48 Mean platelet volume;Platelet distribution width; BRCA cis rs12950390 0.853 rs67441169 chr17:45854462 T/G cg03474202 chr17:45855739 NA -0.48 -12.72 -0.45 3.53e-33 IgG glycosylation; BRCA cis rs7520050 0.778 rs3014218 chr1:46026328 A/C cg24296786 chr1:45957014 TESK2 0.47 10.67 0.39 1.49e-24 Red blood cell count;Reticulocyte count; BRCA trans rs11098499 0.505 rs75122014 chr4:120362426 G/C cg25214090 chr10:38739885 LOC399744 0.57 12.94 0.46 3.6e-34 Corneal astigmatism; BRCA cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg18132916 chr6:79620363 NA 0.46 10.48 0.38 7.91e-24 Intelligence (multi-trait analysis); BRCA cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg17211192 chr8:82754475 SNX16 0.5 11.26 0.41 5.69e-27 Diastolic blood pressure; BRCA cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg25173405 chr17:45401733 C17orf57 0.53 11.18 0.4 1.31e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -8.55 -0.32 8.94e-17 Glomerular filtration rate (creatinine); BRCA cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg22467129 chr15:76604101 ETFA -0.47 -10.41 -0.38 1.53e-23 Blood metabolite levels; BRCA cis rs9868809 0.772 rs2286651 chr3:48694147 G/A cg00383909 chr3:49044727 WDR6 0.64 10.42 0.38 1.4e-23 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.4 0.38 1.61e-23 Bladder cancer; BRCA cis rs4363385 0.791 rs10788855 chr1:153002359 A/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.06 -0.34 1.62e-18 Inflammatory skin disease; BRCA cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg22974920 chr21:40686053 BRWD1 -0.39 -8.77 -0.33 1.59e-17 Cognitive function; BRCA cis rs9790314 0.690 rs9860738 chr3:160843290 G/A cg03342759 chr3:160939853 NMD3 -0.53 -11.33 -0.41 3.02e-27 Morning vs. evening chronotype; BRCA cis rs41005 1.000 rs41005 chr2:8111231 A/G cg03155496 chr2:8117019 LOC339788 -0.55 -14.97 -0.51 1.25e-43 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs1003719 0.680 rs2835619 chr21:38505380 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3008870 0.959 rs2985826 chr1:67412918 G/C cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.82 0.67 8.71e-85 Lymphocyte percentage of white cells; BRCA cis rs262150 1.000 rs262154 chr7:158773936 G/A cg09640425 chr7:158790006 NA -0.4 -8.47 -0.32 1.63e-16 Facial morphology (factor 20); BRCA cis rs36051895 0.664 rs7847141 chr9:5097171 A/T cg02405213 chr9:5042618 JAK2 -0.51 -9.71 -0.36 7.13e-21 Pediatric autoimmune diseases; BRCA cis rs758324 0.947 rs380182 chr5:131319036 A/G cg06307176 chr5:131281290 NA -0.52 -10.33 -0.38 2.99e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs9815354 0.812 rs17217746 chr3:41926021 A/G cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg01877450 chr7:97915802 BRI3 -0.38 -8.83 -0.33 1.01e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs926392 0.640 rs2867899 chr20:37694622 C/A cg16355469 chr20:37678765 NA 0.51 11.73 0.42 6.22e-29 Dialysis-related mortality; BRCA cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg17971929 chr21:40555470 PSMG1 -0.5 -11.02 -0.4 5.6e-26 Menarche (age at onset); BRCA cis rs938554 0.513 rs4529048 chr4:9997112 G/T cg00071950 chr4:10020882 SLC2A9 0.39 8.35 0.31 4.27e-16 Blood metabolite levels; BRCA cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs13064411 0.696 rs9869318 chr3:113146271 T/C cg18753928 chr3:113234510 CCDC52 -0.52 -9.73 -0.36 5.87e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA trans rs61931739 0.534 rs6488189 chr12:33995865 C/T cg26384229 chr12:38710491 ALG10B 0.67 14.16 0.49 8.93e-40 Morning vs. evening chronotype; BRCA cis rs35306767 0.855 rs35825568 chr10:950760 C/T cg26597838 chr10:835615 NA 1.02 17.21 0.56 7.67e-55 Eosinophil percentage of granulocytes; BRCA cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg11764359 chr7:65958608 NA 0.61 13.37 0.47 4.18e-36 Calcium levels; BRCA cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg07917127 chr4:99064746 C4orf37 0.44 8.11 0.31 2.59e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs887829 0.569 rs4148326 chr2:234673462 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.31 -8.24 -0.31 9.97e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg19784903 chr17:45786737 TBKBP1 0.34 8.06 0.3 3.7e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg24642439 chr20:33292090 TP53INP2 -0.54 -11.77 -0.42 4.23e-29 Glomerular filtration rate (creatinine); BRCA cis rs782590 0.967 rs62165173 chr2:55741666 T/C cg18811423 chr2:55921094 PNPT1 0.72 23.31 0.68 1.83e-87 Metabolic syndrome; BRCA trans rs9325144 0.647 rs17518186 chr12:38883665 T/C cg23762105 chr12:34175262 ALG10 0.36 8.4 0.32 2.81e-16 Morning vs. evening chronotype; BRCA cis rs13006833 0.668 rs291447 chr2:191177005 A/C cg11845111 chr2:191398756 TMEM194B 0.34 7.82 0.3 2.24e-14 Urinary metabolites; BRCA cis rs7267979 0.966 rs2151144 chr20:25414924 G/C cg08601574 chr20:25228251 PYGB -0.33 -8.13 -0.31 2.24e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7707921 0.881 rs73134747 chr5:81378294 C/T cg15871215 chr5:81402204 ATG10 -0.4 -8.25 -0.31 9.27e-16 Breast cancer; BRCA cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg11663144 chr21:46675770 NA -0.61 -14.32 -0.49 1.47e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8180040 0.966 rs60369822 chr3:47479735 A/C cg27129171 chr3:47204927 SETD2 -0.68 -15.7 -0.53 3.31e-47 Colorectal cancer; BRCA cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.53 -8.98 -0.33 3.02e-18 Birth weight; BRCA trans rs225245 0.782 rs321617 chr17:33915246 A/G cg19694781 chr19:47549865 TMEM160 -0.32 -7.85 -0.3 1.8e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs57590327 0.503 rs1464790 chr3:81852923 A/T cg07356753 chr3:81810745 GBE1 0.43 10.08 0.37 2.78e-22 Extraversion; BRCA trans rs3857536 0.813 rs6455091 chr6:66949127 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.43 -0.38 1.25e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg24692254 chr21:30365293 RNF160 0.68 18.19 0.58 6.97e-60 Dental caries; BRCA cis rs9399135 0.967 rs4451151 chr6:135310546 C/T cg24558204 chr6:135376177 HBS1L 0.46 12.65 0.45 6.82e-33 Red blood cell count; BRCA cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg05340658 chr4:99064831 C4orf37 0.6 12.93 0.46 3.99e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.621 rs11246345 chr11:934924 T/C ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.21e-47 Alzheimer's disease (late onset); BRCA cis rs7301016 0.802 rs11613011 chr12:63023078 T/C cg01804193 chr12:63026212 NA 0.47 8.29 0.31 6.7e-16 IgG glycosylation; BRCA cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg03433033 chr1:76189801 ACADM 0.6 10.78 0.39 5.18e-25 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs61931739 0.500 rs35030191 chr12:34548865 C/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.19 0.49 6.21e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2652834 0.950 rs2729789 chr15:63400345 G/A cg05507819 chr15:63340323 TPM1 0.45 8.06 0.3 3.83e-15 HDL cholesterol; BRCA cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg18357645 chr12:58087776 OS9 -0.34 -8.35 -0.31 4.39e-16 Multiple sclerosis; BRCA cis rs1829883 0.862 rs2460655 chr5:98797742 C/T cg08333243 chr5:99726346 NA -0.35 -8.05 -0.3 3.91e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs6840360 0.571 rs1822346 chr4:152525303 G/C cg22705602 chr4:152727874 NA -0.32 -8.31 -0.31 5.88e-16 Intelligence (multi-trait analysis); BRCA cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg27535305 chr1:53392650 SCP2 0.32 7.84 0.3 1.93e-14 Monocyte count; BRCA trans rs9858542 0.953 rs9811982 chr3:49624377 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.62 -0.36 1.46e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg00106254 chr7:1943704 MAD1L1 -0.32 -8.17 -0.31 1.6e-15 Schizophrenia; BRCA trans rs1005277 0.579 rs2474568 chr10:38383147 A/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.83 -0.48 2.9e-38 Extrinsic epigenetic age acceleration; BRCA cis rs3784262 1.000 rs4646622 chr15:58257199 A/G cg12031962 chr15:58353849 ALDH1A2 -0.48 -12.68 -0.45 4.82e-33 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9858542 0.953 rs35261698 chr3:49537839 C/G cg03060546 chr3:49711283 APEH -0.54 -10.99 -0.4 7.38e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg08045932 chr20:61659980 NA 0.51 11.6 0.42 2.23e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs6752107 1.000 rs6752107 chr2:234161448 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.52 0.41 4.9e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1505368 0.781 rs10197836 chr2:213274278 T/C cg20637307 chr2:213403960 ERBB4 0.38 9.19 0.34 5.4e-19 Symmetrical dimethylarginine levels; BRCA cis rs9649465 1.000 rs9649465 chr7:123376560 G/A cg04330084 chr7:123175371 IQUB -0.33 -9.0 -0.34 2.52e-18 Migraine; BRCA cis rs758324 0.947 rs422291 chr5:131320942 A/T cg06307176 chr5:131281290 NA -0.54 -10.67 -0.39 1.42e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs300703 0.542 rs376385 chr2:190245 G/A cg21211680 chr2:198530 NA 0.4 8.81 0.33 1.21e-17 Blood protein levels; BRCA cis rs2742234 0.590 rs741968 chr10:43611708 A/G cg02780029 chr10:43622663 RET -0.36 -8.06 -0.3 3.84e-15 Hirschsprung disease; BRCA cis rs12347191 0.500 rs925485 chr9:100619561 G/C cg13688889 chr9:100608707 NA -0.49 -9.92 -0.37 1.19e-21 Orofacial clefts; BRCA cis rs7914558 0.933 rs1538204 chr10:104733893 T/A cg04362960 chr10:104952993 NT5C2 0.44 10.71 0.39 1.02e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg16482183 chr6:26056742 HIST1H1C 0.53 11.04 0.4 4.7e-26 Height; BRCA cis rs17604090 0.878 rs4000281 chr7:29726287 A/G cg19413766 chr7:29689036 LOC646762 -0.61 -8.69 -0.33 2.95e-17 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs9486719 0.656 rs6924957 chr6:96853579 G/T cg06623918 chr6:96969491 KIAA0776 0.75 16.86 0.55 4.99e-53 Migraine;Coronary artery disease; BRCA cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg26373071 chr5:1325741 CLPTM1L 0.4 9.47 0.35 5.31e-20 Lung cancer; BRCA cis rs782590 0.967 rs62165172 chr2:55736237 A/G cg18811423 chr2:55921094 PNPT1 0.73 23.59 0.68 5.34e-89 Metabolic syndrome; BRCA cis rs10746514 0.833 rs1888601 chr1:232266922 C/T cg09506761 chr1:232265262 NA -0.43 -8.75 -0.33 1.93e-17 Response to statin therapy; BRCA cis rs4243830 0.850 rs10746502 chr1:6607199 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.89 -17.78 -0.58 9.64e-58 Body mass index; BRCA trans rs6951245 0.872 rs75493422 chr7:1072890 C/T cg13565492 chr6:43139072 SRF -0.79 -11.09 -0.4 3.05e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs62380364 0.565 rs617944 chr5:88057915 T/C cg22951263 chr5:87985283 NA -0.37 -10.28 -0.38 4.86e-23 Intelligence (multi-trait analysis); BRCA cis rs12200560 0.505 rs211173 chr6:97070804 C/T cg06623918 chr6:96969491 KIAA0776 0.52 12.25 0.44 3.94e-31 Coronary heart disease; BRCA cis rs875971 0.862 rs801209 chr7:66019390 G/T cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA cis rs6878727 0.626 rs696477 chr5:123672578 C/T cg01806427 chr5:123737813 NA -0.36 -8.17 -0.31 1.62e-15 Breast cancer; BRCA trans rs11098499 0.730 rs78971550 chr4:120281041 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.59 0.42 2.45e-28 Corneal astigmatism; BRCA cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg04586622 chr2:25135609 ADCY3 0.4 9.39 0.35 1.05e-19 Body mass index; BRCA cis rs17376456 1.000 rs6867042 chr5:93555761 C/T cg25358565 chr5:93447407 FAM172A 1.25 19.24 0.61 1.94e-65 Diabetic retinopathy; BRCA cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg03517284 chr6:25882590 NA -0.47 -10.66 -0.39 1.57e-24 Blood metabolite levels; BRCA cis rs853679 0.517 rs9380052 chr6:28064623 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.26 -0.31 8.39e-16 Depression; BRCA cis rs4363385 0.818 rs61811862 chr1:152995668 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.91 -0.33 5.17e-18 Inflammatory skin disease; BRCA cis rs13064411 0.696 rs9808893 chr3:113228444 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -12.31 -0.44 2.2e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg02734326 chr4:10020555 SLC2A9 0.42 9.07 0.34 1.43e-18 Bone mineral density; BRCA trans rs4718428 0.672 rs13241598 chr7:66300652 A/G cg18876405 chr7:65276391 NA 0.43 8.24 0.31 9.61e-16 Corneal structure; BRCA trans rs11764590 0.950 rs55683212 chr7:2078855 G/C cg25206134 chr2:45395956 NA 0.52 8.99 0.34 2.8e-18 Neuroticism; BRCA cis rs36051895 0.632 rs7038813 chr9:5177685 A/G cg02405213 chr9:5042618 JAK2 -0.48 -9.26 -0.34 2.95e-19 Pediatric autoimmune diseases; BRCA cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg06618935 chr21:46677482 NA -0.37 -8.14 -0.31 2.07e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg06191203 chr2:152266755 RIF1 -0.33 -10.11 -0.37 2.11e-22 Lung cancer; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg08470875 chr2:26401718 FAM59B -0.52 -8.58 -0.32 6.93e-17 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.14e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs10883723 0.810 rs913025 chr10:104276043 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.32 0.59 1.4e-60 Allergic disease (asthma, hay fever or eczema); BRCA cis rs3857536 0.740 rs9354391 chr6:66890183 C/T cg07460842 chr6:66804631 NA 0.45 8.8 0.33 1.22e-17 Blood trace element (Cu levels); BRCA cis rs6582630 0.502 rs2204008 chr12:38439203 C/T cg13010199 chr12:38710504 ALG10B 0.47 9.49 0.35 4.42e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg23708337 chr7:1209742 NA 0.5 9.82 0.36 2.71e-21 Longevity;Endometriosis; BRCA cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg26031613 chr14:104095156 KLC1 -0.43 -8.51 -0.32 1.19e-16 Schizophrenia; BRCA cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg07395648 chr5:131743802 NA 0.37 9.35 0.35 1.4e-19 Blood metabolite levels; BRCA cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 12.06 0.43 2.62e-30 Rheumatoid arthritis; BRCA cis rs9379850 0.528 rs67575965 chr6:26196593 A/G cg01420254 chr6:26195488 NA 0.45 7.81 0.3 2.32e-14 Intelligence (multi-trait analysis); BRCA cis rs17401966 1.000 rs17401924 chr1:10384439 A/G cg15208524 chr1:10270712 KIF1B 0.38 8.18 0.31 1.53e-15 Hepatocellular carcinoma; BRCA cis rs13136331 0.641 rs2627685 chr4:88657792 T/C cg12990093 chr4:88570587 DMP1 -0.4 -8.22 -0.31 1.14e-15 Sitting height ratio; BRCA trans rs208520 0.507 rs3903670 chr6:66812183 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -38.83 -0.84 2.69e-170 Exhaled nitric oxide output; BRCA cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.62e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7618501 0.572 rs4688756 chr3:50040194 T/A cg24110177 chr3:50126178 RBM5 -0.37 -9.9 -0.36 1.36e-21 Intelligence (multi-trait analysis); BRCA cis rs1003719 0.762 rs3787787 chr21:38463452 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs17209837 0.607 rs45553044 chr7:87085613 A/G cg00919237 chr7:87102261 ABCB4 -0.53 -10.24 -0.38 6.86e-23 Gallbladder cancer; BRCA cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg27446573 chr6:127587934 RNF146 -0.54 -12.01 -0.43 4.06e-30 Breast cancer; BRCA cis rs10870270 0.956 rs10870293 chr10:133771413 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -13.92 -0.48 1.16e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg08132940 chr7:1081526 C7orf50 -0.52 -8.33 -0.31 4.99e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8017423 0.647 rs12882973 chr14:90820502 G/A cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs10876993 0.928 rs2928053 chr12:58063475 T/C cg18357645 chr12:58087776 OS9 0.47 13.88 0.48 1.82e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg10150615 chr22:24372951 LOC391322 -0.44 -9.85 -0.36 2.02e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2576037 0.583 rs641366 chr18:44430326 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -13.45 -0.47 1.66e-36 Personality dimensions; BRCA trans rs11098499 0.954 rs6847248 chr4:120225955 A/G cg25214090 chr10:38739885 LOC399744 0.57 11.64 0.42 1.56e-28 Corneal astigmatism; BRCA cis rs523522 0.962 rs9040 chr12:120900274 C/T cg12219531 chr12:120966889 COQ5 0.56 11.49 0.41 6.72e-28 High light scatter reticulocyte count; BRCA cis rs1375194 0.606 rs2044644 chr2:33817559 A/G cg04131969 chr2:33951647 MYADML -0.42 -8.16 -0.31 1.76e-15 Response to antidepressants in depression; BRCA cis rs8180040 0.966 rs34634681 chr3:47579102 G/A cg27129171 chr3:47204927 SETD2 -0.65 -14.35 -0.49 1.1e-40 Colorectal cancer; BRCA cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg10523679 chr1:76189770 ACADM 0.75 15.64 0.53 6.2e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg05347473 chr6:146136440 FBXO30 0.43 8.57 0.32 7.57e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg10729496 chr3:10149963 C3orf24 0.47 8.84 0.33 8.98e-18 Alzheimer's disease; BRCA cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.5 -10.72 -0.39 8.94e-25 Calcium levels; BRCA cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg23625390 chr15:77176239 SCAPER 0.44 10.97 0.4 9.14e-26 Blood metabolite levels; BRCA trans rs3857536 0.813 rs9354403 chr6:66943426 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.31e-15 Blood trace element (Cu levels); BRCA cis rs57590327 0.503 rs13062741 chr3:81887124 C/T cg07356753 chr3:81810745 GBE1 -0.43 -10.08 -0.37 2.9e-22 Extraversion; BRCA cis rs826838 0.651 rs12367384 chr12:38618460 G/T cg26384229 chr12:38710491 ALG10B 0.59 13.39 0.47 3.37e-36 Heart rate; BRCA cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2282802 0.685 rs7715538 chr5:139665181 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.15e-15 Intelligence (multi-trait analysis); BRCA cis rs6088813 0.961 rs981819 chr20:33924112 C/T cg14752227 chr20:34000481 UQCC 0.41 8.61 0.32 5.48e-17 Height; BRCA cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg18904891 chr8:8559673 CLDN23 0.58 11.06 0.4 3.75e-26 Obesity-related traits; BRCA cis rs3806843 1.000 rs10477034 chr5:140169730 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.74e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg03425785 chr20:62221387 GMEB2 0.51 8.25 0.31 8.77e-16 Glioblastoma; BRCA cis rs16870629 0.541 rs2334955 chr5:1062444 A/G cg00278107 chr5:1061253 SLC12A7 -0.73 -16.07 -0.54 4.83e-49 QT interval; BRCA cis rs7385804 0.761 rs507392 chr7:100319936 G/A cg16850897 chr7:100343110 ZAN 0.37 8.46 0.32 1.85e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs11098499 0.754 rs12507565 chr4:120251121 G/A cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Parkinson's disease; BRCA cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.99 0.48 5.27e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs870825 0.616 rs4444873 chr4:185628406 A/G cg04058563 chr4:185651563 MLF1IP 0.78 16.81 0.55 8.5e-53 Blood protein levels; BRCA cis rs965469 0.779 rs6133031 chr20:3300857 A/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.73 -0.33 2.27e-17 IFN-related cytopenia; BRCA cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg18225595 chr11:63971243 STIP1 -0.53 -9.93 -0.37 1.04e-21 Mean platelet volume; BRCA cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg05623727 chr3:50126028 RBM5 0.49 11.63 0.42 1.64e-28 Intelligence (multi-trait analysis); BRCA cis rs1865760 1.000 rs12209482 chr6:25909229 T/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.27 0.41 5.3e-27 Height; BRCA cis rs1865760 1.000 rs7757666 chr6:25902626 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.18 0.4 1.23e-26 Height; BRCA cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA trans rs3733585 0.699 rs1079128 chr4:9951221 T/C cg26043149 chr18:55253948 FECH -0.36 -7.87 -0.3 1.52e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg03146154 chr1:46216737 IPP 0.54 12.02 0.43 3.92e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg03264133 chr6:25882463 NA -0.43 -9.43 -0.35 7.6e-20 Intelligence (multi-trait analysis); BRCA cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg12365402 chr11:9010492 NRIP3 -0.39 -9.01 -0.34 2.33e-18 Hemoglobin concentration; BRCA cis rs9463078 0.803 rs2396380 chr6:45043557 T/A cg25276700 chr6:44698697 NA -0.36 -8.33 -0.31 5.08e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9457247 0.663 rs10946205 chr6:167451311 A/G cg07741184 chr6:167504864 NA 0.28 8.23 0.31 1.09e-15 Crohn's disease; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg09256448 chr16:638327 NA 0.3 7.94 0.3 9.28e-15 Height; BRCA cis rs490234 0.966 rs569408 chr9:128304824 G/A cg14078157 chr9:128172775 NA 0.33 7.89 0.3 1.3e-14 Mean arterial pressure; BRCA cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg20019365 chr2:219134978 PNKD;AAMP -0.54 -11.51 -0.41 5.36e-28 Colorectal cancer; BRCA trans rs2204008 0.774 rs11520273 chr12:38354075 A/T cg06521331 chr12:34319734 NA -0.44 -8.35 -0.31 4.37e-16 Bladder cancer; BRCA trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg13010199 chr12:38710504 ALG10B 0.5 9.82 0.36 2.8e-21 Morning vs. evening chronotype; BRCA trans rs7615952 0.512 rs4679430 chr3:125357893 T/C cg07211511 chr3:129823064 LOC729375 -0.58 -10.64 -0.39 1.84e-24 Blood pressure (smoking interaction); BRCA cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg10596483 chr8:143751796 JRK 0.4 8.6 0.32 6.13e-17 Schizophrenia; BRCA cis rs586533 0.881 rs631338 chr11:99498158 T/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs1577917 1.000 rs10498958 chr6:86649705 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.54 14.35 0.49 1.16e-40 Response to antipsychotic treatment; BRCA cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg02574844 chr11:5959923 NA -0.44 -8.66 -0.32 3.75e-17 DNA methylation (variation); BRCA cis rs4803468 0.935 rs13346603 chr19:41945837 T/A cg09537434 chr19:41945824 ATP5SL 1.03 24.89 0.7 3.9e-96 Height; BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs6738485 1.000 rs6738485 chr2:106809960 C/T cg16099169 chr2:106886729 NA -0.4 -8.04 -0.3 4.24e-15 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.500 rs7311284 chr12:34478477 C/G cg06521331 chr12:34319734 NA -0.56 -10.28 -0.38 4.75e-23 Morning vs. evening chronotype; BRCA cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.87 0.3 1.52e-14 Melanoma; BRCA cis rs600806 0.815 rs3768495 chr1:109935325 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs12905246 chr15:45500841 C/T cg24006582 chr15:45444508 DUOX1 0.56 10.78 0.39 5.32e-25 Uric acid levels; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.95 0.33 3.69e-18 Platelet count; BRCA cis rs7589728 1.000 rs7589728 chr2:88518440 G/A cg07952391 chr2:88470173 THNSL2 0.56 7.86 0.3 1.66e-14 Plasma clusterin levels; BRCA cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.72 -19.58 -0.61 2.96e-67 Electrocardiographic conduction measures; BRCA cis rs3008870 0.917 rs12044492 chr1:67461667 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg09177884 chr7:1199841 ZFAND2A -0.43 -9.12 -0.34 9.63e-19 Longevity;Endometriosis; BRCA cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg15556689 chr8:8085844 FLJ10661 0.49 13.61 0.47 3.2e-37 Mood instability; BRCA cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.37e-15 Depression; BRCA trans rs78049276 0.512 rs6820938 chr4:148395903 A/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.54 -11.33 -0.41 2.95e-27 Pulse pressure; BRCA cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg04586622 chr2:25135609 ADCY3 0.44 11.31 0.41 3.75e-27 Body mass index; BRCA cis rs2549003 1.000 rs2549009 chr5:131826765 T/C cg02551604 chr5:131831745 NA 0.38 13.78 0.48 5.02e-38 Asthma (sex interaction); BRCA cis rs9394841 0.667 rs9471667 chr6:41776681 T/C cg08135965 chr6:41755394 TOMM6 0.5 8.21 0.31 1.19e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.78 0.36 3.7e-21 Gut microbiome composition (summer); BRCA cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.86 -0.33 7.77e-18 Alzheimer's disease (late onset); BRCA cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg19077165 chr18:44547161 KATNAL2 0.56 12.25 0.44 3.76e-31 Personality dimensions; BRCA trans rs208520 0.837 rs208489 chr6:66927584 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.36 -0.54 1.72e-50 Exhaled nitric oxide output; BRCA cis rs73242632 1.000 rs2276896 chr4:57845091 C/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.71 8.59 0.32 6.46e-17 Congenital heart disease (maternal effect); BRCA cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg01884057 chr2:25150051 NA -0.34 -9.02 -0.34 2.09e-18 Body mass index in non-asthmatics; BRCA cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg13944838 chr5:179740914 GFPT2 -0.69 -14.48 -0.5 2.77e-41 Height; BRCA cis rs10193935 0.901 rs222469 chr2:42640235 T/C cg27598129 chr2:42591480 NA -0.85 -14.33 -0.49 1.4e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs1153858 1.000 rs11852800 chr15:45639131 A/G cg21132104 chr15:45694354 SPATA5L1 -0.69 -15.14 -0.51 1.82e-44 Homoarginine levels; BRCA cis rs11971779 0.564 rs6467841 chr7:139066092 T/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs17741873 0.779 rs3812635 chr10:75594302 T/G cg07699608 chr10:75541558 CHCHD1 0.5 8.19 0.31 1.38e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.57 14.79 0.51 8.56e-43 Electrocardiographic conduction measures; BRCA cis rs9612 1.000 rs16976747 chr19:44238152 G/A cg08581076 chr19:44259116 C19orf61 0.62 10.99 0.4 7.77e-26 Exhaled nitric oxide output; BRCA cis rs28374715 0.562 rs8036686 chr15:41550333 C/T cg18705301 chr15:41695430 NDUFAF1 -0.56 -12.26 -0.44 3.34e-31 Ulcerative colitis; BRCA cis rs1468333 1.000 rs1468333 chr5:137552970 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.34 0.35 1.55e-19 Resting heart rate; BRCA cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg23711669 chr6:146136114 FBXO30 0.74 16.17 0.54 1.48e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg19717773 chr7:2847554 GNA12 -0.43 -9.49 -0.35 4.36e-20 Height; BRCA cis rs34779708 0.897 rs11010131 chr10:35513316 A/C cg03585969 chr10:35415529 CREM 0.48 9.7 0.36 7.42e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg12386194 chr3:101231763 SENP7 0.45 9.52 0.35 3.48e-20 Colorectal cancer; BRCA cis rs2066819 1.000 rs74673257 chr12:56638077 T/C cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg13010199 chr12:38710504 ALG10B 0.44 9.39 0.35 1.07e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs2070488 0.931 rs6599212 chr3:38558906 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.7 -19.21 -0.61 2.91e-65 Electrocardiographic conduction measures; BRCA cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg20790798 chr5:1857306 NA -0.38 -9.09 -0.34 1.23e-18 Cardiovascular disease risk factors; BRCA cis rs13064411 0.696 rs6438156 chr3:113206929 C/A cg18753928 chr3:113234510 CCDC52 -0.59 -12.34 -0.44 1.56e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg27478167 chr7:817139 HEATR2 -0.42 -9.03 -0.34 2.01e-18 Cerebrospinal P-tau181p levels; BRCA cis rs10463316 0.817 rs6880228 chr5:150778145 A/T cg03212797 chr5:150827313 SLC36A1 0.39 7.85 0.3 1.7e-14 Metabolite levels (Pyroglutamine); BRCA cis rs72781680 0.678 rs56145919 chr2:24088489 A/G cg08917208 chr2:24149416 ATAD2B 0.61 10.23 0.38 7.31e-23 Lymphocyte counts; BRCA cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg20503657 chr10:835505 NA 1.03 18.42 0.59 4.53e-61 Eosinophil percentage of granulocytes; BRCA trans rs208520 0.690 rs12213581 chr6:66735818 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.74 0.63 1.96e-73 Exhaled nitric oxide output; BRCA cis rs3857067 0.806 rs10008044 chr4:95092850 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.45 -0.35 6.42e-20 QT interval; BRCA cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22307029 chr19:49891270 CCDC155 0.68 12.33 0.44 1.65e-31 Multiple sclerosis; BRCA cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.42 -0.32 2.54e-16 Monocyte percentage of white cells; BRCA cis rs2243480 1.000 rs59794892 chr7:65415873 G/A cg18252515 chr7:66147081 NA -0.82 -11.87 -0.42 1.69e-29 Diabetic kidney disease; BRCA cis rs1878931 0.624 rs27235 chr16:3439138 G/C cg02880119 chr16:3481970 NA 0.45 8.38 0.31 3.47e-16 Body mass index (adult); BRCA cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs6973256 0.897 rs10231829 chr7:133348338 T/A cg07491979 chr7:133331646 EXOC4 -0.39 -9.04 -0.34 1.92e-18 Intelligence (multi-trait analysis); BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.91 -14.98 -0.51 1.08e-43 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs35110281 0.805 rs3788062 chr21:44991159 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.51 0.32 1.25e-16 Mean corpuscular volume; BRCA trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg08975724 chr8:8085496 FLJ10661 -0.43 -8.5 -0.32 1.33e-16 Retinal vascular caliber; BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg06636001 chr8:8085503 FLJ10661 0.46 9.89 0.36 1.45e-21 Neuroticism; BRCA cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg24060327 chr5:131705240 SLC22A5 -0.47 -10.04 -0.37 3.91e-22 Blood metabolite levels; BRCA cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg01877450 chr7:97915802 BRI3 -0.37 -8.31 -0.31 5.64e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7927592 0.913 rs2282563 chr11:68333200 C/T cg20283391 chr11:68216788 NA -0.46 -9.07 -0.34 1.49e-18 Total body bone mineral density; BRCA cis rs6121246 0.559 rs6060716 chr20:30274847 C/G cg13852791 chr20:30311386 BCL2L1 0.95 23.18 0.68 9.54e-87 Mean corpuscular hemoglobin; BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg23285459 chr7:2802560 GNA12 -0.38 -9.44 -0.35 6.97e-20 Height; BRCA trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.18 0.34 5.72e-19 Morning vs. evening chronotype; BRCA cis rs72781680 0.898 rs10490751 chr2:24001356 A/G cg20701182 chr2:24300061 SF3B14 0.55 8.51 0.32 1.21e-16 Lymphocyte counts; BRCA cis rs6582630 0.502 rs4309219 chr12:38293584 A/G cg26384229 chr12:38710491 ALG10B 0.65 15.36 0.52 1.48e-45 Drug-induced liver injury (flucloxacillin); BRCA cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg08045932 chr20:61659980 NA 0.49 11.35 0.41 2.41e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs7395662 0.504 rs1814158 chr11:48437937 C/T cg15704280 chr7:45808275 SEPT13 -0.44 -8.4 -0.32 2.79e-16 HDL cholesterol; BRCA cis rs11051970 0.679 rs2733696 chr12:32554635 A/G cg02745156 chr12:32552066 NA 0.25 8.47 0.32 1.65e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs3617 0.625 rs2245647 chr3:52862753 A/G cg11645453 chr3:52864694 ITIH4 0.37 9.9 0.36 1.4e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg05340658 chr4:99064831 C4orf37 0.66 16.11 0.54 3.02e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs739401 0.572 rs389128 chr11:3083873 G/T cg25174290 chr11:3078921 CARS 0.44 12.78 0.45 1.86e-33 Longevity; BRCA cis rs3916 0.794 rs3021337 chr12:121163261 C/T cg21892295 chr12:121157589 UNC119B -0.4 -11.45 -0.41 9.41e-28 Urinary metabolites (H-NMR features); BRCA cis rs7631605 0.586 rs56990886 chr3:37298243 G/A cg15934958 chr3:37212084 LRRFIP2 0.39 8.29 0.31 6.92e-16 Cerebrospinal P-tau181p levels; BRCA cis rs1878931 0.696 rs35175748 chr16:3445427 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.97 25.76 0.71 7.07e-101 Body mass index (adult); BRCA cis rs709400 0.930 rs57447494 chr14:104034569 G/A cg24130564 chr14:104152367 KLC1 -0.38 -9.07 -0.34 1.4e-18 Body mass index; BRCA cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg05283184 chr6:79620031 NA -0.43 -11.1 -0.4 2.77e-26 Intelligence (multi-trait analysis); BRCA cis rs2425143 1.000 rs117010355 chr20:34343442 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.11 -0.34 1.09e-18 Blood protein levels; BRCA cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg12219531 chr12:120966889 COQ5 0.55 11.44 0.41 1.11e-27 High light scatter reticulocyte count; BRCA cis rs490234 0.934 rs571675 chr9:128297692 C/T cg14078157 chr9:128172775 NA 0.33 7.97 0.3 7.46e-15 Mean arterial pressure; BRCA cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.05 0.3 4.09e-15 Aortic root size; BRCA cis rs3768617 0.565 rs10752898 chr1:183077896 A/G ch.1.3577855R chr1:183094577 LAMC1 0.61 15.81 0.53 9.71e-48 Fuchs's corneal dystrophy; BRCA cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.9 -0.33 5.88e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs17253792 0.822 rs28409547 chr14:56047826 C/T cg01858014 chr14:56050164 KTN1 -0.77 -11.27 -0.41 5.52e-27 Putamen volume; BRCA cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs1580019 0.844 rs1901202 chr7:32503724 A/T cg07520158 chr7:32535189 LSM5;AVL9 0.44 9.15 0.34 7.77e-19 Cognitive ability; BRCA cis rs9443645 0.527 rs9343870 chr6:79789473 T/G cg05283184 chr6:79620031 NA -0.35 -8.0 -0.3 5.75e-15 Intelligence (multi-trait analysis); BRCA trans rs9291683 0.588 rs12647117 chr4:10022059 T/C cg26043149 chr18:55253948 FECH 0.4 8.53 0.32 1.07e-16 Bone mineral density; BRCA cis rs887829 0.570 rs10168155 chr2:234596836 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.29 -0.31 6.48e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg03188948 chr7:1209495 NA 0.86 11.81 0.42 3.02e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2710642 0.962 rs6545972 chr2:63084682 G/A cg17519650 chr2:63277830 OTX1 0.37 8.16 0.31 1.8e-15 LDL cholesterol levels;LDL cholesterol; BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.6 -11.61 -0.42 2.06e-28 Alzheimer's disease; BRCA cis rs1949733 1.000 rs1880023 chr4:8480831 C/T cg11789530 chr4:8429930 ACOX3 -0.68 -17.89 -0.58 2.47e-58 Response to antineoplastic agents; BRCA cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg24549020 chr5:56110836 MAP3K1 0.55 10.96 0.4 9.58e-26 Initial pursuit acceleration; BRCA cis rs523522 0.962 rs12814055 chr12:120987391 G/A cg12219531 chr12:120966889 COQ5 0.54 11.32 0.41 3.35e-27 High light scatter reticulocyte count; BRCA cis rs34779708 0.931 rs35997236 chr10:35376690 C/T cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.63e-15 Menopause (age at onset); BRCA cis rs780094 0.585 rs7586601 chr2:27584666 A/G cg22903471 chr2:27725779 GCKR -0.32 -7.85 -0.3 1.77e-14 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs2760061 0.598 rs673726 chr1:228120173 T/C cg02753203 chr1:228287806 NA -0.6 -13.03 -0.46 1.4e-34 Diastolic blood pressure; BRCA cis rs853679 0.517 rs868987 chr6:28110148 A/G cg02631126 chr6:28058918 ZSCAN12L1 -0.27 -7.94 -0.3 9.23e-15 Depression; BRCA trans rs1005277 0.522 rs11011343 chr10:38002698 A/G cg17830980 chr10:43048298 ZNF37B -0.42 -9.86 -0.36 1.92e-21 Extrinsic epigenetic age acceleration; BRCA cis rs7179456 0.545 rs585192 chr15:59052210 T/C cg05156742 chr15:59063176 FAM63B 0.48 9.68 0.36 8.92e-21 Asperger disorder; BRCA cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg14349672 chr11:133703707 NA -0.43 -9.58 -0.35 2.16e-20 Childhood ear infection; BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg16606324 chr3:10149918 C3orf24 0.57 11.01 0.4 5.98e-26 Alzheimer's disease; BRCA cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg16586182 chr3:47516702 SCAP 0.53 11.4 0.41 1.62e-27 Colorectal cancer; BRCA cis rs9318086 0.673 rs7981928 chr13:24435180 T/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.33 9.63 0.36 1.33e-20 Myopia (pathological); BRCA cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.91e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg13393036 chr8:95962371 TP53INP1 -0.3 -8.07 -0.3 3.54e-15 Type 2 diabetes; BRCA cis rs4689388 0.926 rs4689394 chr4:6291003 C/G cg25554036 chr4:6271136 WFS1 -0.41 -9.76 -0.36 4.38e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg23711669 chr6:146136114 FBXO30 0.78 17.99 0.58 7.28e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836633 0.929 rs2836610 chr21:40044502 C/T cg05519781 chr21:40033154 ERG 0.38 8.06 0.3 3.63e-15 Coronary artery disease; BRCA cis rs7131987 0.507 rs3782507 chr12:29445530 T/C cg09582351 chr12:29534625 ERGIC2 -0.35 -8.18 -0.31 1.52e-15 QT interval; BRCA cis rs2019216 0.564 rs907707 chr17:21910083 G/C cg22648282 chr17:21454238 C17orf51 -0.41 -9.38 -0.35 1.13e-19 Pelvic organ prolapse; BRCA cis rs7246657 0.663 rs10408619 chr19:38070474 C/T cg23950597 chr19:37808831 NA -0.51 -8.78 -0.33 1.44e-17 Coronary artery calcification; BRCA cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.03 0.4 4.9e-26 Bipolar disorder; BRCA cis rs7552404 0.731 rs1689275 chr1:76409655 T/C cg03433033 chr1:76189801 ACADM -0.52 -10.28 -0.38 4.82e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg20701182 chr2:24300061 SF3B14 0.7 13.37 0.47 4.01e-36 Lymphocyte counts; BRCA cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg18404041 chr3:52824283 ITIH1 -0.4 -11.9 -0.43 1.26e-29 Bipolar disorder; BRCA cis rs6456156 0.792 rs7775443 chr6:167513252 A/C cg07741184 chr6:167504864 NA -0.32 -9.2 -0.34 4.84e-19 Primary biliary cholangitis; BRCA cis rs2011503 1.000 rs1560687 chr19:19562902 G/A cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg24838063 chr12:130822603 PIWIL1 0.68 16.73 0.55 2.13e-52 Menopause (age at onset); BRCA cis rs4808199 0.895 rs10403731 chr19:19469296 G/A cg01262667 chr19:19385393 TM6SF2 0.38 7.95 0.3 8.64e-15 Nonalcoholic fatty liver disease; BRCA cis rs8062405 1.000 rs55830740 chr16:28847149 G/C cg09754948 chr16:28834200 ATXN2L 0.47 9.17 0.34 6.53e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7762018 0.607 rs3800544 chr6:170058374 C/T cg19338460 chr6:170058176 WDR27 -0.76 -10.64 -0.39 1.91e-24 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg11189052 chr15:85197271 WDR73 -0.5 -12.41 -0.44 7.48e-32 P wave terminal force; BRCA cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg15605315 chr1:45957053 TESK2 -0.46 -9.28 -0.34 2.54e-19 High light scatter reticulocyte count; BRCA cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.68e-24 Motion sickness; BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg21747090 chr2:27597821 SNX17 -0.38 -8.08 -0.3 3.29e-15 Menopause (age at onset); BRCA cis rs2882667 0.898 rs13163536 chr5:138377219 A/G cg04439458 chr5:138467593 SIL1 -0.33 -8.87 -0.33 7.19e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg00106254 chr7:1943704 MAD1L1 -0.38 -8.81 -0.33 1.16e-17 Bipolar disorder and schizophrenia; BRCA cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg01579765 chr21:45077557 HSF2BP 0.44 11.13 0.4 2.08e-26 Mean corpuscular volume; BRCA cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg05340658 chr4:99064831 C4orf37 0.62 14.75 0.5 1.38e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs926392 0.799 rs742274 chr20:37680944 T/C cg16355469 chr20:37678765 NA 0.33 8.28 0.31 7.43e-16 Dialysis-related mortality; BRCA cis rs7954584 0.567 rs1720033 chr12:122384344 C/T cg13699009 chr12:122356056 WDR66 -0.36 -8.27 -0.31 8.05e-16 Mean corpuscular volume; BRCA cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg24531977 chr5:56204891 C5orf35 0.71 15.65 0.53 5.85e-47 Initial pursuit acceleration; BRCA cis rs7586879 0.719 rs7565468 chr2:25130092 C/T cg01884057 chr2:25150051 NA 0.31 7.83 0.3 2.1e-14 Body mass index; BRCA cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.94e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg17971929 chr21:40555470 PSMG1 0.61 14.0 0.48 4.72e-39 Cognitive function; BRCA cis rs7267979 0.966 rs2227892 chr20:25264814 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg26898376 chr11:64110657 CCDC88B 0.38 8.18 0.31 1.53e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg12419862 chr22:24373484 LOC391322 -0.65 -14.78 -0.5 9.86e-43 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg04267008 chr7:1944627 MAD1L1 -0.57 -12.59 -0.45 1.2e-32 Bipolar disorder and schizophrenia; BRCA cis rs79976124 0.879 rs12213669 chr6:66627704 G/A cg07460842 chr6:66804631 NA 0.6 10.2 0.37 1.01e-22 Type 2 diabetes; BRCA cis rs6456156 0.586 rs7746628 chr6:167483235 A/G cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA trans rs3780486 0.757 rs10758189 chr9:33125804 A/G cg20290983 chr6:43655470 MRPS18A 1.11 40.5 0.85 1.23e-178 IgG glycosylation; BRCA cis rs2658782 0.756 rs3019205 chr11:93109553 A/G cg15737290 chr11:93063684 CCDC67 0.49 9.85 0.36 2.07e-21 Pulmonary function decline; BRCA cis rs2668423 0.502 rs2074898 chr19:1391361 A/G cg02639931 chr19:1387894 NDUFS7 -0.87 -26.5 -0.72 5.97e-105 Nonalcoholic fatty liver disease; BRCA cis rs651907 0.737 rs9844218 chr3:101584983 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.47 -9.95 -0.37 8.88e-22 Colorectal cancer; BRCA cis rs17741873 0.836 rs17630952 chr10:75601414 T/A cg07699608 chr10:75541558 CHCHD1 0.53 8.49 0.32 1.4e-16 Paclitaxel disposition in epithelial ovarian cancer; BRCA trans rs61931739 0.534 rs11052984 chr12:34045904 T/C cg26384229 chr12:38710491 ALG10B 0.56 12.05 0.43 2.7e-30 Morning vs. evening chronotype; BRCA cis rs921968 0.541 rs561570 chr2:219379348 T/A cg10223061 chr2:219282414 VIL1 -0.27 -8.13 -0.31 2.21e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs1035144 0.505 rs6574617 chr14:81457615 G/A cg06600135 chr14:81408086 NA -0.47 -11.07 -0.4 3.56e-26 Male sexual orientation; BRCA trans rs11098499 0.874 rs6826823 chr4:120112098 G/C cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.8e-24 Corneal astigmatism; BRCA cis rs3768617 0.510 rs20557 chr1:183093875 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs9926296 0.744 rs164749 chr16:89708224 A/C cg01097406 chr16:89675127 NA 0.38 8.66 0.32 3.85e-17 Vitiligo; BRCA cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg18132916 chr6:79620363 NA -0.48 -10.89 -0.4 1.89e-25 Intelligence (multi-trait analysis); BRCA trans rs6952808 1.000 rs6954521 chr7:1886865 C/A cg04565464 chr8:145669602 NFKBIL2 0.37 8.14 0.31 2.09e-15 Bipolar disorder and schizophrenia; BRCA cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.52 7.99 0.3 6.18e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2732480 0.577 rs2634680 chr12:48734564 T/C cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 5.97e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs7520050 0.966 rs7539932 chr1:46292354 C/T cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.38e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.29e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1801251 1.000 rs2012221 chr2:233566848 T/C cg08000102 chr2:233561755 GIGYF2 0.62 13.71 0.48 1.15e-37 Coronary artery disease; BRCA cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg08508325 chr11:3079039 CARS -0.41 -14.4 -0.5 6.31e-41 Longevity; BRCA cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg15145296 chr3:125709740 NA -0.55 -8.64 -0.32 4.36e-17 Blood pressure (smoking interaction); BRCA cis rs4713118 0.662 rs149969 chr6:27977737 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.26 7.99 0.3 6.19e-15 Parkinson's disease; BRCA cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 9.44 0.35 6.68e-20 Rheumatoid arthritis; BRCA cis rs796364 0.694 rs1653299 chr2:201075611 A/G cg17644776 chr2:200775616 C2orf69 0.45 9.07 0.34 1.47e-18 Schizophrenia; BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.21e-18 Tonsillectomy; BRCA cis rs11190604 1.000 rs2495734 chr10:102338686 G/A cg07080220 chr10:102295463 HIF1AN 0.56 12.25 0.44 4e-31 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg03146154 chr1:46216737 IPP 0.47 10.51 0.38 6.17e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2635047 1.000 rs2635043 chr18:44679769 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 8.3 0.31 6.15e-16 Educational attainment; BRCA cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.09 0.49 1.91e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3771570 1.000 rs3771564 chr2:242355701 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.21 0.34 4.65e-19 Prostate cancer; BRCA cis rs9527 0.544 rs11191549 chr10:104846797 C/T cg04362960 chr10:104952993 NT5C2 0.46 10.4 0.38 1.58e-23 Arsenic metabolism; BRCA trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA cis rs9790314 0.659 rs13066683 chr3:160847410 A/G cg04691961 chr3:161091175 C3orf57 -0.37 -8.18 -0.31 1.49e-15 Morning vs. evening chronotype; BRCA cis rs6700896 0.931 rs12042807 chr1:66134052 T/C cg04111102 chr1:66153794 NA 0.36 8.67 0.32 3.57e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 12.56 0.45 1.65e-32 Personality dimensions; BRCA cis rs7586879 0.828 rs2384056 chr2:25092649 G/A cg04586622 chr2:25135609 ADCY3 0.38 9.11 0.34 1.06e-18 Body mass index; BRCA cis rs1865760 1.000 rs7757666 chr6:25902626 T/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.34 0.38 2.87e-23 Height; BRCA cis rs1371867 0.846 rs1788194 chr8:101277916 T/C cg06002616 chr8:101225028 SPAG1 -0.32 -7.96 -0.3 7.95e-15 Atrioventricular conduction; BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg20607798 chr8:58055168 NA 0.54 8.41 0.32 2.71e-16 Developmental language disorder (linguistic errors); BRCA trans rs9951602 0.512 rs7232551 chr18:76650702 G/A cg02800362 chr5:177631904 HNRNPAB 0.77 18.01 0.58 5.8e-59 Obesity-related traits; BRCA cis rs7851660 0.901 rs7873389 chr9:100609230 C/T cg13688889 chr9:100608707 NA -0.35 -8.5 -0.32 1.3e-16 Strep throat; BRCA cis rs870825 0.616 rs4616798 chr4:185634144 C/T cg04058563 chr4:185651563 MLF1IP -0.76 -17.51 -0.57 2.31e-56 Blood protein levels; BRCA cis rs11098499 0.954 rs6846442 chr4:120326323 G/A cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA trans rs11227306 0.934 rs2303385 chr11:65640562 G/A cg17712092 chr4:129076599 LARP1B -0.38 -8.19 -0.31 1.47e-15 DNA methylation (variation); BRCA cis rs870825 0.616 rs7678849 chr4:185648868 T/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs4363385 0.747 rs7529110 chr1:152966247 A/C cg25856811 chr1:152973957 SPRR3 -0.35 -9.53 -0.35 3.12e-20 Inflammatory skin disease; BRCA cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg10932868 chr11:921992 NA 0.38 9.02 0.34 2.13e-18 Alzheimer's disease (late onset); BRCA trans rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05039488 chr6:79577232 IRAK1BP1 0.36 7.99 0.3 6.53e-15 Endometrial cancer; BRCA cis rs4803468 0.967 rs2304243 chr19:41942708 C/G cg09537434 chr19:41945824 ATP5SL 1.03 25.67 0.71 2.15e-100 Height; BRCA cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg05294307 chr14:35346193 BAZ1A -0.59 -10.22 -0.37 8.46e-23 Psoriasis; BRCA cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -16.12 -0.54 2.54e-49 Axial length; BRCA cis rs6546550 0.901 rs6546558 chr2:70145717 C/T cg02498382 chr2:70120550 SNRNP27 -0.54 -11.7 -0.42 8.85e-29 Prevalent atrial fibrillation; BRCA cis rs7246657 1.000 rs12709812 chr19:37794850 A/G cg23950597 chr19:37808831 NA 0.66 11.4 0.41 1.63e-27 Coronary artery calcification; BRCA cis rs698833 0.886 rs4953090 chr2:44565194 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.55 0.39 4.13e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs3760982 0.585 rs11673490 chr19:44298885 C/A cg12072164 chr19:44306565 LYPD5 0.37 8.71 0.33 2.57e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg15412446 chr2:106886593 NA -0.49 -9.03 -0.34 2.05e-18 Facial morphology (factor 23); BRCA cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.599 rs11181807 chr12:38403763 G/A cg26384229 chr12:38710491 ALG10B -0.42 -9.88 -0.36 1.65e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs1468333 1.000 rs2057831 chr5:137535133 G/A cg27119451 chr5:137514611 BRD8;KIF20A 0.43 9.12 0.34 9.58e-19 Resting heart rate; BRCA cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.02 0.3 5.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg03146154 chr1:46216737 IPP 0.53 11.88 0.43 1.46e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs877282 0.947 rs7923867 chr10:768094 G/A cg22713356 chr15:30763199 NA 1.35 26.99 0.73 1.24e-107 Uric acid levels; BRCA cis rs7766436 0.885 rs13211957 chr6:22573415 C/T cg13666174 chr6:22585274 NA -0.45 -9.63 -0.36 1.35e-20 Coronary artery disease; BRCA cis rs9462027 0.628 rs2764207 chr6:34712998 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 2e-14 Systemic lupus erythematosus; BRCA cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg18357526 chr6:26021779 HIST1H4A 0.46 8.22 0.31 1.11e-15 Intelligence (multi-trait analysis); BRCA cis rs7098414 0.511 rs7898787 chr10:82156042 G/A cg00277334 chr10:82204260 NA -0.48 -10.1 -0.37 2.42e-22 Post bronchodilator FEV1; BRCA cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.95 0.46 3.16e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7727544 0.678 rs7735891 chr5:131597005 C/T cg14196790 chr5:131705035 SLC22A5 0.44 11.33 0.41 3.17e-27 Blood metabolite levels; BRCA cis rs7635838 0.654 rs4684766 chr3:11285474 G/A cg00170343 chr3:11313890 ATG7 0.43 8.37 0.31 3.65e-16 HDL cholesterol; BRCA cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.26 0.31 8.28e-16 Aortic root size; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.66 -0.59 2.46e-62 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs637571 0.780 rs677029 chr11:65683531 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.52 10.46 0.38 9.23e-24 Eosinophil percentage of white cells; BRCA cis rs79839061 0.611 rs2279183 chr4:882404 T/C cg07828340 chr4:882639 GAK 0.6 9.57 0.35 2.35e-20 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs1015996 chr1:152976108 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg20203395 chr5:56204925 C5orf35 -0.51 -10.24 -0.38 6.6e-23 Initial pursuit acceleration; BRCA cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg06453172 chr10:134556979 INPP5A -0.51 -10.85 -0.39 2.71e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3815700 1.000 rs8109990 chr19:33095636 A/G cg02997394 chr19:33096574 ANKRD27 0.69 11.38 0.41 1.83e-27 Eosinophilic esophagitis; BRCA cis rs11190604 1.000 rs7477246 chr10:102261538 C/T cg07080220 chr10:102295463 HIF1AN 0.61 14.5 0.5 2.12e-41 Palmitoleic acid (16:1n-7) levels; BRCA trans rs1493916 0.805 rs1452648 chr18:31411003 G/T cg15819921 chr19:927150 ARID3A -0.41 -8.11 -0.31 2.57e-15 Life satisfaction; BRCA cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg22800045 chr5:56110881 MAP3K1 -0.41 -8.28 -0.31 7.28e-16 Initial pursuit acceleration; BRCA cis rs2749592 0.588 rs2504144 chr10:38383525 C/T cg00409905 chr10:38381863 ZNF37A -0.51 -9.54 -0.35 2.94e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg13880726 chr7:1868755 MAD1L1 0.53 9.85 0.36 2.14e-21 Bipolar disorder and schizophrenia; BRCA trans rs6582630 0.555 rs6582503 chr12:38557886 A/C cg06521331 chr12:34319734 NA -0.5 -9.06 -0.34 1.58e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs2953174 1.000 rs1133353 chr2:241522267 A/T cg07929629 chr2:241523174 NA -0.49 -7.99 -0.3 6.29e-15 Bipolar disorder; BRCA cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg11833968 chr6:79620685 NA -0.38 -8.45 -0.32 1.9e-16 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.48e-66 Mean platelet volume; BRCA cis rs7072216 0.763 rs10732782 chr10:100166506 C/A cg26618903 chr10:100175079 PYROXD2 -0.31 -8.96 -0.33 3.58e-18 Metabolite levels; BRCA cis rs7412746 0.611 rs6660084 chr1:150748803 T/C cg18016565 chr1:150552671 MCL1 0.34 7.86 0.3 1.59e-14 Melanoma; BRCA cis rs929596 0.755 rs887829 chr2:234668570 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.41 10.41 0.38 1.51e-23 Total bilirubin levels in HIV-1 infection; BRCA cis rs1371614 0.632 rs920437 chr2:27157396 G/A cg00617064 chr2:27272375 NA 0.31 8.08 0.3 3.15e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6942756 0.806 rs68184415 chr7:128988862 C/T cg02491457 chr7:128862824 NA -0.59 -12.39 -0.44 9.26e-32 White matter hyperintensity burden; BRCA cis rs10463316 0.894 rs6891272 chr5:150762842 G/T cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs6540559 0.673 rs7550857 chr1:209956542 C/A cg22029157 chr1:209979665 IRF6 0.55 11.27 0.41 5.13e-27 Cleft lip with or without cleft palate; BRCA cis rs2797160 1.000 rs6927161 chr6:126015954 T/C cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.2e-20 Endometrial cancer; BRCA cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg04450456 chr4:17643702 FAM184B -0.34 -9.59 -0.35 1.97e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9486715 0.867 rs9384602 chr6:96919561 G/A cg06623918 chr6:96969491 KIAA0776 0.87 24.36 0.69 3.16e-93 Headache; BRCA cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.52 10.06 0.37 3.27e-22 Lung cancer in ever smokers; BRCA cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg22800045 chr5:56110881 MAP3K1 0.41 8.2 0.31 1.28e-15 Coronary artery disease; BRCA trans rs12517041 0.935 rs36035239 chr5:23294107 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs67981189 0.513 rs7154395 chr14:71566300 G/A cg15816911 chr14:71606274 NA 0.37 8.27 0.31 7.93e-16 Schizophrenia; BRCA cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg02734326 chr4:10020555 SLC2A9 0.4 8.61 0.32 5.56e-17 Bone mineral density; BRCA cis rs1499972 0.941 rs62263082 chr3:117605611 C/T cg07612923 chr3:117604196 NA 0.59 7.94 0.3 9.02e-15 Schizophrenia; BRCA trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg03929089 chr4:120376271 NA -0.76 -17.18 -0.56 1.19e-54 Coronary artery disease; BRCA cis rs17270561 0.609 rs4131670 chr6:25738619 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.72 0.33 2.44e-17 Iron status biomarkers; BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.2 0.34 5.04e-19 Tonsillectomy; BRCA cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.26 0.31 8.68e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg25036284 chr2:26402008 FAM59B 0.95 15.98 0.53 1.27e-48 Gut microbiome composition (summer); BRCA cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.57 -11.93 -0.43 9.16e-30 Chronic sinus infection; BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.37 8.76 0.33 1.68e-17 Tonsillectomy; BRCA cis rs68170813 0.559 rs76843318 chr7:106863173 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.47 -0.32 1.72e-16 Coronary artery disease; BRCA cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg08917208 chr2:24149416 ATAD2B 0.91 13.46 0.47 1.5e-36 Lymphocyte counts; BRCA cis rs9649465 0.967 rs11769381 chr7:123264804 C/T cg03229431 chr7:123269106 ASB15 -0.35 -8.08 -0.3 3.17e-15 Migraine; BRCA cis rs3845702 1.000 rs3845702 chr2:180848488 A/C cg01881094 chr2:180872142 CWC22 0.65 13.47 0.47 1.32e-36 Schizophrenia; BRCA cis rs6665290 0.901 rs68087483 chr1:227202668 T/C cg10327440 chr1:227177885 CDC42BPA -1.14 -44.85 -0.87 1.43e-199 Myeloid white cell count; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg03354898 chr7:1950403 MAD1L1 -0.44 -9.14 -0.34 8.4e-19 Bipolar disorder and schizophrenia; BRCA cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg11789530 chr4:8429930 ACOX3 -0.69 -17.87 -0.58 3.07e-58 Response to antineoplastic agents; BRCA cis rs7927592 0.913 rs67605986 chr11:68300955 C/T cg20283391 chr11:68216788 NA -0.46 -8.98 -0.33 3.03e-18 Total body bone mineral density; BRCA cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg11843238 chr5:131593191 PDLIM4 0.32 7.87 0.3 1.52e-14 Blood metabolite levels; BRCA cis rs7178424 1.000 rs7177276 chr15:62379668 C/T cg00456672 chr15:62358751 C2CD4A -0.34 -8.16 -0.31 1.81e-15 Height; BRCA cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg20607287 chr7:12443886 VWDE -0.54 -8.16 -0.31 1.83e-15 Coronary artery disease; BRCA cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg06697600 chr4:7070879 GRPEL1 -0.53 -10.64 -0.39 1.82e-24 Monocyte percentage of white cells; BRCA cis rs4319547 1.000 rs6489071 chr12:123025576 C/G cg23029597 chr12:123009494 RSRC2 -0.61 -12.46 -0.44 4.66e-32 Body mass index; BRCA trans rs61931739 0.534 rs2625897 chr12:34064295 G/A cg26384229 chr12:38710491 ALG10B 0.52 11.18 0.4 1.28e-26 Morning vs. evening chronotype; BRCA cis rs7520050 0.966 rs7556615 chr1:46461369 G/A cg24296786 chr1:45957014 TESK2 0.43 9.66 0.36 1.03e-20 Red blood cell count;Reticulocyte count; BRCA cis rs2197308 0.765 rs117216293 chr12:37882982 T/C cg26384229 chr12:38710491 ALG10B -0.58 -13.44 -0.47 1.83e-36 Morning vs. evening chronotype; BRCA cis rs17376456 0.809 rs12152763 chr5:93405509 T/A cg25358565 chr5:93447407 FAM172A 1.22 18.58 0.59 6.16e-62 Diabetic retinopathy; BRCA cis rs10504073 0.647 rs62507247 chr8:50013554 T/G cg00325661 chr8:49890786 NA 0.47 13.22 0.46 1.95e-35 Blood metabolite ratios; BRCA cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg11752832 chr7:134001865 SLC35B4 0.52 13.55 0.47 6.19e-37 Mean platelet volume; BRCA cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg14582100 chr15:45693742 SPATA5L1 0.37 11.95 0.43 7.89e-30 Homoarginine levels; BRCA cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg07606381 chr6:8435919 SLC35B3 0.64 14.02 0.48 4.01e-39 Motion sickness; BRCA cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg01877450 chr7:97915802 BRI3 -0.39 -8.63 -0.32 5e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6977660 0.714 rs10486365 chr7:19801364 A/G cg07541023 chr7:19748670 TWISTNB 0.54 9.85 0.36 2.18e-21 Thyroid stimulating hormone; BRCA cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.81 -22.11 -0.66 7.01e-81 Chronic sinus infection; BRCA cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg02018176 chr4:1364513 KIAA1530 0.41 8.24 0.31 1.01e-15 Longevity; BRCA cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg17143192 chr8:8559678 CLDN23 0.5 9.62 0.36 1.54e-20 Obesity-related traits; BRCA cis rs16976116 0.901 rs28535372 chr15:55500602 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg00071950 chr4:10020882 SLC2A9 0.64 15.96 0.53 1.59e-48 Bone mineral density; BRCA cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg23625390 chr15:77176239 SCAPER 0.38 9.64 0.36 1.29e-20 Blood metabolite levels; BRCA cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg09904177 chr6:26538194 HMGN4 0.51 14.84 0.51 5.26e-43 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.774 rs2387811 chr12:38369794 C/A cg06521331 chr12:34319734 NA -0.51 -9.19 -0.34 5.34e-19 Bladder cancer; BRCA cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg10862848 chr6:42927986 GNMT 0.27 8.8 0.33 1.3e-17 Blood protein levels; BRCA cis rs7833790 0.927 rs61020899 chr8:82757090 C/T cg27398817 chr8:82754497 SNX16 0.45 8.72 0.33 2.34e-17 Diastolic blood pressure; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg09877947 chr5:131593287 PDLIM4 0.41 10.46 0.38 9.65e-24 Breast cancer; BRCA cis rs11249608 0.548 rs34054398 chr5:178458371 A/G cg21905437 chr5:178450457 ZNF879 0.51 10.66 0.39 1.53e-24 Pubertal anthropometrics; BRCA cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.89e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg02734326 chr4:10020555 SLC2A9 0.39 8.3 0.31 6.29e-16 Bone mineral density; BRCA cis rs2625529 0.824 rs4777470 chr15:72207518 T/A cg16672083 chr15:72433130 SENP8 -0.83 -17.19 -0.56 9.91e-55 Red blood cell count; BRCA cis rs2559856 1.000 rs2251187 chr12:102081889 G/A cg12924262 chr12:102091054 CHPT1 0.36 8.13 0.31 2.22e-15 Blood protein levels; BRCA cis rs2153535 0.580 rs6926759 chr6:8456176 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 6.83e-41 Motion sickness; BRCA cis rs926392 0.547 rs8118808 chr20:37674996 C/G cg16355469 chr20:37678765 NA 0.49 10.92 0.4 1.42e-25 Dialysis-related mortality; BRCA cis rs897080 0.515 rs698790 chr2:44683018 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.36 0.35 1.33e-19 Height; BRCA cis rs7824557 0.724 rs2572398 chr8:11178093 A/C cg27411982 chr8:10470053 RP1L1 0.34 8.07 0.3 3.49e-15 Retinal vascular caliber; BRCA cis rs2559856 0.935 rs7957666 chr12:102081551 T/C cg12924262 chr12:102091054 CHPT1 0.36 8.16 0.31 1.81e-15 Blood protein levels; BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.93 0.58 1.63e-58 Alzheimer's disease; BRCA cis rs701145 0.585 rs1713822 chr3:153863505 A/G cg12800244 chr3:153838788 SGEF 0.62 7.83 0.3 2.1e-14 Coronary artery disease; BRCA cis rs11098499 0.865 rs1112817 chr4:120297800 T/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg16850897 chr7:100343110 ZAN -0.61 -13.08 -0.46 8.34e-35 Other erythrocyte phenotypes; BRCA cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg18225595 chr11:63971243 STIP1 0.53 9.59 0.35 1.8899999999999998e-20 Mean platelet volume; BRCA cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg18963800 chr10:38644991 HSD17B7P2 -0.4 -7.92 -0.3 1.04e-14 Extrinsic epigenetic age acceleration; BRCA cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg02187348 chr16:89574699 SPG7 0.52 12.47 0.44 4.35e-32 Multiple myeloma (IgH translocation); BRCA cis rs4363385 0.747 rs2339491 chr1:152985322 T/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.93 -0.37 1.06e-21 Inflammatory skin disease; BRCA cis rs6782228 0.527 rs2811491 chr3:128353950 C/A cg16766828 chr3:128327626 NA -0.44 -9.81 -0.36 2.95e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs534126 0.736 rs10239488 chr7:142949599 C/G cg15652212 chr7:142981776 TMEM139 0.46 10.44 0.38 1.12e-23 Cancer; BRCA trans rs637571 0.522 rs679581 chr11:65746653 A/G cg17712092 chr4:129076599 LARP1B 0.56 13.51 0.47 9.06e-37 Eosinophil percentage of white cells; BRCA cis rs11190604 0.673 rs10883498 chr10:102228709 T/A cg07080220 chr10:102295463 HIF1AN 0.49 11.31 0.41 3.76e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10501293 1.000 rs4755695 chr11:43108344 C/A cg03447554 chr11:43094025 NA -0.47 -8.81 -0.33 1.22e-17 Cognitive performance; BRCA cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.0 0.37 5.7e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2304069 0.913 rs9324637 chr5:149390947 T/C cg12661370 chr5:149340060 SLC26A2 0.57 8.32 0.31 5.49e-16 HIV-1 control; BRCA cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg20891558 chr2:74357851 NA 0.51 12.11 0.43 1.53e-30 Gestational age at birth (maternal effect); BRCA cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.07 0.37 2.95e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg20503657 chr10:835505 NA 0.56 10.1 0.37 2.43e-22 Response to angiotensin II receptor blocker therapy; BRCA trans rs800082 0.690 rs2118001 chr3:144336609 T/C cg24215973 chr2:240111563 HDAC4 -0.4 -10.09 -0.37 2.61e-22 Smoking behavior; BRCA trans rs9291683 0.632 rs13101785 chr4:10042915 T/A cg26043149 chr18:55253948 FECH 0.43 9.22 0.34 4.29e-19 Bone mineral density; BRCA cis rs614226 0.935 rs7137953 chr12:120894685 C/T cg01236616 chr12:121019343 POP5 -1.15 -25.16 -0.71 1.34e-97 Type 1 diabetes nephropathy; BRCA cis rs9486719 1.000 rs9400016 chr6:96940883 G/T cg06623918 chr6:96969491 KIAA0776 -0.72 -13.22 -0.46 1.88e-35 Migraine;Coronary artery disease; BRCA cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg16339924 chr4:17578868 LAP3 -0.53 -12.68 -0.45 5.22e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6087990 0.735 rs2889703 chr20:31379184 C/A cg13636640 chr20:31349939 DNMT3B 0.56 16.14 0.54 1.99e-49 Ulcerative colitis; BRCA cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg13902645 chr11:5959945 NA -0.54 -10.74 -0.39 7.65e-25 DNA methylation (variation); BRCA cis rs10751667 0.580 rs10751664 chr11:927077 T/G ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs9814567 1.000 rs11708531 chr3:134224902 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs4650994 1.000 rs4076205 chr1:178534157 G/A cg05059571 chr16:84539110 KIAA1609 -0.37 -8.38 -0.31 3.45e-16 HDL cholesterol levels;HDL cholesterol; BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA trans rs66887589 0.967 rs13104219 chr4:120438174 G/T cg25214090 chr10:38739885 LOC399744 0.36 8.17 0.31 1.7e-15 Diastolic blood pressure; BRCA cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg19748678 chr4:122722346 EXOSC9 0.71 14.93 0.51 1.79e-43 Type 2 diabetes; BRCA cis rs35995292 0.500 rs2392606 chr7:38926955 C/A cg19327137 chr7:38886074 VPS41 0.38 12.69 0.45 4.63e-33 Subjective well-being (multi-trait analysis); BRCA trans rs8002861 0.967 rs9533690 chr13:44480598 T/C cg17145862 chr1:211918768 LPGAT1 0.69 18.15 0.58 1.04e-59 Leprosy; BRCA cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg01475377 chr6:109611718 NA -0.6 -16.14 -0.54 1.98e-49 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.11e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2070488 1.000 rs13079757 chr3:38491444 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.56 0.63 1.72e-72 Electrocardiographic conduction measures; BRCA trans rs9409565 0.658 rs2809768 chr9:97128369 G/A cg05679027 chr9:99775184 HIATL2 0.43 9.43 0.35 7.23e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg02544614 chr20:61657117 NA 0.28 7.93 0.3 1.01e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs4466137 0.953 rs1420654 chr5:82975793 G/A cg15083037 chr5:83017644 HAPLN1 -0.51 -9.92 -0.37 1.13e-21 Prostate cancer; BRCA cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg06784218 chr1:46089804 CCDC17 0.46 11.0 0.4 6.86e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg18402987 chr7:1209562 NA 0.66 11.19 0.4 1.1e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs7408868 1.000 rs7254735 chr19:15263385 A/G cg14696996 chr19:15285081 NOTCH3 0.81 12.89 0.45 5.86e-34 Pulse pressure; BRCA cis rs7011049 1.000 rs11997538 chr8:53832663 A/C cg26025543 chr8:53854495 NA 0.56 10.31 0.38 3.84e-23 Systolic blood pressure; BRCA cis rs9811920 0.965 rs9849632 chr3:99867211 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.52 12.42 0.44 7.18e-32 Axial length; BRCA cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg09904177 chr6:26538194 HMGN4 0.47 14.83 0.51 5.48e-43 Intelligence (multi-trait analysis); BRCA cis rs7481584 0.581 rs406598 chr11:3076285 G/A cg08508325 chr11:3079039 CARS 0.29 8.69 0.32 3.15e-17 Calcium levels; BRCA cis rs11792861 0.816 rs28361186 chr9:111704064 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 8.02 0.3 5.09e-15 Menarche (age at onset); BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.79 -12.49 -0.44 3.49e-32 Platelet count; BRCA cis rs2479724 0.811 rs8393 chr6:41757836 C/A cg17623882 chr6:41773611 USP49 0.33 8.92 0.33 5.04e-18 Menarche (age at onset); BRCA cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg08999081 chr20:33150536 PIGU 0.5 14.24 0.49 3.57e-40 Coronary artery disease; BRCA cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg18132916 chr6:79620363 NA -0.5 -11.5 -0.41 5.87e-28 Intelligence (multi-trait analysis); BRCA cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg22875332 chr1:76189707 ACADM 0.68 14.73 0.5 1.7e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2617583 0.509 rs10630 chr5:1462720 G/A cg07148919 chr5:1466943 LPCAT1 -0.37 -7.86 -0.3 1.68e-14 Breast cancer; BRCA cis rs992157 0.835 rs10932768 chr2:219146199 T/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.16 -0.4 1.58e-26 Colorectal cancer; BRCA cis rs919433 1.000 rs7422899 chr2:198163527 G/C cg10820045 chr2:198174542 NA -0.39 -8.22 -0.31 1.14e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs28374715 0.532 rs1899 chr15:41689232 C/T cg18705301 chr15:41695430 NDUFAF1 -1.05 -27.04 -0.73 6.42e-108 Ulcerative colitis; BRCA cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.51 -0.32 1.19e-16 Bipolar disorder; BRCA cis rs739401 0.572 rs389128 chr11:3083873 G/T cg05729581 chr11:3078854 CARS -0.33 -7.89 -0.3 1.31e-14 Longevity; BRCA trans rs208520 1.000 rs208529 chr6:66957549 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -13.59 -0.47 3.96e-37 Exhaled nitric oxide output; BRCA cis rs1595825 0.945 rs16826320 chr2:198845623 T/C cg19156104 chr2:198669113 PLCL1 -0.44 -8.24 -0.31 9.67e-16 Ulcerative colitis; BRCA cis rs7149337 0.780 rs4369569 chr14:51689181 C/G cg23942311 chr14:51606299 NA -0.51 -14.42 -0.5 5.39e-41 Cancer; BRCA cis rs6570726 0.811 rs375873 chr6:145812371 G/T cg23711669 chr6:146136114 FBXO30 0.61 13.85 0.48 2.51e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg22800045 chr5:56110881 MAP3K1 0.45 8.94 0.33 4.13e-18 Initial pursuit acceleration; BRCA cis rs698813 0.674 rs7590224 chr2:44501209 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 8.04 0.3 4.32e-15 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs921968 0.541 rs10205073 chr2:219412784 C/A cg02176678 chr2:219576539 TTLL4 -0.51 -12.98 -0.46 2.41e-34 Mean corpuscular hemoglobin concentration; BRCA cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.28e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2882667 0.690 rs4835703 chr5:138150737 T/G cg04439458 chr5:138467593 SIL1 0.35 8.47 0.32 1.63e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg01475377 chr6:109611718 NA 0.6 16.69 0.55 3.45e-52 Reticulocyte fraction of red cells; BRCA cis rs6570726 0.935 rs398060 chr6:145841515 C/T cg23711669 chr6:146136114 FBXO30 -0.66 -14.74 -0.5 1.46e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs4891159 0.790 rs689885 chr18:74110563 T/G cg24786174 chr18:74118243 ZNF516 0.73 18.22 0.58 4.81e-60 Longevity; BRCA cis rs12541635 1.000 rs12541635 chr8:107090000 C/T cg10147462 chr8:107024639 NA -0.3 -8.34 -0.31 4.64e-16 Age of smoking initiation; BRCA cis rs7264396 0.563 rs2425094 chr20:34306974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Total cholesterol levels; BRCA cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg18404041 chr3:52824283 ITIH1 -0.41 -12.03 -0.43 3.6e-30 Bipolar disorder; BRCA cis rs45509595 0.841 rs401754 chr6:27782538 T/A cg26587870 chr6:27730563 NA -0.52 -8.02 -0.3 5.04e-15 Breast cancer; BRCA cis rs724568 0.546 rs737359 chr2:67950714 A/G cg14046302 chr2:67939758 NA 0.39 10.28 0.38 4.66e-23 Major depressive disorder (broad); BRCA cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg07606381 chr6:8435919 SLC35B3 0.64 14.09 0.49 1.87e-39 Motion sickness; BRCA cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg07636037 chr3:49044803 WDR6 0.58 8.27 0.31 7.6e-16 Menarche (age at onset); BRCA cis rs2030401 0.604 rs2682427 chr12:123656809 C/T cg00376283 chr12:123451042 ABCB9 0.35 8.26 0.31 8.28e-16 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs96067 0.805 rs3767705 chr1:36602044 A/T cg24686825 chr1:36642396 MAP7D1 -0.44 -8.35 -0.31 4.37e-16 Corneal structure; BRCA cis rs7937840 0.581 rs4963286 chr11:61887232 C/A cg01969543 chr11:61895209 INCENP -0.39 -8.53 -0.32 1.08e-16 Breast cancer; BRCA cis rs853679 0.517 rs4711164 chr6:28115156 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Depression; BRCA cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.25 0.34 3.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1048238 0.506 rs848212 chr1:16263452 A/G cg21385522 chr1:16154831 NA -0.46 -9.96 -0.37 7.89e-22 Systolic blood pressure; BRCA cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg00686598 chr14:53173677 PSMC6 1.15 16.59 0.55 1.11e-51 Alzheimer's disease (late onset); BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg08470875 chr2:26401718 FAM59B -0.72 -11.43 -0.41 1.14e-27 Gut microbiome composition (summer); BRCA cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.32 0.49 1.51e-40 Motion sickness; BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg19346786 chr7:2764209 NA -0.35 -10.19 -0.37 1.03e-22 Height; BRCA cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg14458575 chr2:238380390 NA 0.55 12.32 0.44 1.87e-31 Prostate cancer; BRCA cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.27 0.34 2.82e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg19626725 chr5:178986131 RUFY1 0.32 9.64 0.36 1.29e-20 Lung cancer; BRCA cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg18132916 chr6:79620363 NA -0.39 -8.09 -0.3 3.05e-15 Intelligence (multi-trait analysis); BRCA cis rs36051895 0.632 rs10758674 chr9:5163645 G/A cg02405213 chr9:5042618 JAK2 -0.47 -9.07 -0.34 1.5e-18 Pediatric autoimmune diseases; BRCA cis rs9469578 0.681 rs78748610 chr6:33714412 T/C cg18708504 chr6:33715942 IP6K3 0.7 10.23 0.38 7.52e-23 Phosphorus levels; BRCA cis rs1003719 0.715 rs2156077 chr21:38539357 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs9443189 0.570 rs6931578 chr6:76272310 C/T cg01950844 chr6:76311363 SENP6 0.86 14.11 0.49 1.52e-39 Prostate cancer; BRCA trans rs9858542 0.953 rs67216675 chr3:49493151 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.66 -0.36 1.04e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9649465 1.000 rs1073670 chr7:123345029 A/C cg04330084 chr7:123175371 IQUB -0.3 -8.32 -0.31 5.51e-16 Migraine; BRCA cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg11663144 chr21:46675770 NA -0.61 -14.26 -0.49 3.01e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9341808 0.754 rs6907729 chr6:81004922 A/T cg08355045 chr6:80787529 NA -0.35 -9.08 -0.34 1.32e-18 Sitting height ratio; BRCA cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.29 -0.41 4.46e-27 Schizophrenia; BRCA cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs2243480 1.000 rs11538349 chr7:65421871 C/T cg18252515 chr7:66147081 NA -0.82 -11.85 -0.42 1.97e-29 Diabetic kidney disease; BRCA cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg13256891 chr4:100009986 ADH5 0.54 10.14 0.37 1.61e-22 Smoking initiation; BRCA cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg08000102 chr2:233561755 GIGYF2 0.61 13.06 0.46 1.02e-34 Coronary artery disease; BRCA cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg27446573 chr6:127587934 RNF146 0.78 17.3 0.56 2.75e-55 Breast cancer; BRCA cis rs36051895 0.632 rs7040806 chr9:5174782 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.82 -0.33 1.04e-17 Pediatric autoimmune diseases; BRCA cis rs72928364 0.929 rs62275197 chr3:100683147 C/T cg10123952 chr3:100791384 NA 0.53 7.88 0.3 1.39e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg15112475 chr7:1198522 ZFAND2A -0.41 -9.37 -0.35 1.2e-19 Longevity;Endometriosis; BRCA cis rs312274 0.630 rs913831 chr12:41227935 T/G cg17827154 chr12:41323612 CNTN1 0.41 9.95 0.37 8.9e-22 Metabolite levels (X-11787); BRCA cis rs13046373 0.508 rs2253516 chr21:31993317 C/T cg24082983 chr21:31802169 KRTAP13-4 0.32 8.05 0.3 3.96e-15 HDL cholesterol; BRCA cis rs9790314 1.000 rs9872514 chr3:161042833 T/C cg03342759 chr3:160939853 NMD3 -0.66 -15.38 -0.52 1.23e-45 Morning vs. evening chronotype; BRCA cis rs12973672 1.000 rs10421599 chr19:35767933 G/A cg12095397 chr19:35769544 USF2 0.37 8.37 0.31 3.71e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.13 0.37 1.79e-22 Bipolar disorder; BRCA cis rs11623869 0.711 rs2403173 chr14:103909289 T/C cg24130564 chr14:104152367 KLC1 -0.34 -7.94 -0.3 8.91e-15 Bone mineral density; BRCA cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 3.78e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg08917208 chr2:24149416 ATAD2B 0.52 8.16 0.31 1.77e-15 Lymphocyte counts; BRCA cis rs881375 0.933 rs2239657 chr9:123671520 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.45 -9.04 -0.34 1.9e-18 Rheumatoid arthritis; BRCA cis rs34779708 0.733 rs61449529 chr10:35543914 T/C cg03585969 chr10:35415529 CREM 0.45 9.17 0.34 6.54e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17376456 1.000 rs9968749 chr5:93509559 A/G cg25358565 chr5:93447407 FAM172A 1.16 18.27 0.59 2.58e-60 Diabetic retinopathy; BRCA cis rs4478858 0.775 rs6701861 chr1:31708125 A/C cg00250761 chr1:31883323 NA -0.32 -8.55 -0.32 9.16e-17 Alcohol dependence; BRCA cis rs9796 0.576 rs13329511 chr15:41299121 T/C cg18705301 chr15:41695430 NDUFAF1 -0.41 -8.25 -0.31 8.85e-16 Menopause (age at onset); BRCA cis rs36051895 0.589 rs4560849 chr9:5203866 C/G cg02405213 chr9:5042618 JAK2 -0.44 -8.27 -0.31 7.94e-16 Pediatric autoimmune diseases; BRCA cis rs7246657 0.943 rs2303131 chr19:37936025 G/A cg23950597 chr19:37808831 NA -0.75 -13.09 -0.46 7.64e-35 Coronary artery calcification; BRCA cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg16179182 chr5:140090404 VTRNA1-1 0.46 10.9 0.4 1.73e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs9649213 0.593 rs3823740 chr7:97957104 T/G cg24562669 chr7:97807699 LMTK2 0.47 12.47 0.44 4.08e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs6547741 1.000 rs1919125 chr2:27801403 C/G cg27432699 chr2:27873401 GPN1 0.46 9.7 0.36 7.89e-21 Oral cavity cancer; BRCA cis rs11690935 0.550 rs55653103 chr2:172861816 T/C cg13550731 chr2:172543902 DYNC1I2 0.5 12.21 0.43 5.77e-31 Schizophrenia; BRCA cis rs16854884 0.657 rs1025984 chr3:143756187 C/G cg06585982 chr3:143692056 C3orf58 -0.39 -8.45 -0.32 1.97e-16 Economic and political preferences (feminism/equality); BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.74 16.27 0.54 4.62e-50 Lymphocyte counts; BRCA cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg08999081 chr20:33150536 PIGU 0.38 8.73 0.33 2.29e-17 Coronary artery disease; BRCA trans rs9291683 0.526 rs12506122 chr4:10033538 C/A cg26043149 chr18:55253948 FECH 0.4 8.71 0.33 2.63e-17 Bone mineral density; BRCA cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.0 0.34 2.55e-18 Lymphocyte counts; BRCA cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg23649088 chr2:200775458 C2orf69 -0.56 -8.69 -0.32 3.13e-17 Schizophrenia; BRCA trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.53 0.47 7.42e-37 Morning vs. evening chronotype; BRCA cis rs4588572 0.644 rs10942856 chr5:77746199 A/G cg11547950 chr5:77652471 NA 0.45 8.65 0.32 4.12e-17 Triglycerides; BRCA cis rs4722166 0.645 rs1404006 chr7:22795077 T/C cg26061582 chr7:22766209 IL6 0.38 8.85 0.33 8.21e-18 Lung cancer; BRCA cis rs9814567 1.000 rs2056604 chr3:134312648 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1165205 0.558 rs793144 chr6:25879321 C/T cg03517284 chr6:25882590 NA -0.78 -18.61 -0.59 4.43e-62 Urate levels; BRCA cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg01017244 chr2:74357527 NA 0.58 13.79 0.48 4.85e-38 Gestational age at birth (maternal effect); BRCA cis rs757081 0.667 rs7108067 chr11:17200220 G/A cg15432903 chr11:17409602 KCNJ11 -0.46 -8.67 -0.32 3.54e-17 Systolic blood pressure; BRCA cis rs10791323 0.593 rs11223599 chr11:133717902 A/T cg14349672 chr11:133703707 NA 0.38 8.92 0.33 5.06e-18 Childhood ear infection; BRCA cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg02551604 chr5:131831745 NA 0.39 14.96 0.51 1.37e-43 Asthma (sex interaction); BRCA cis rs4409675 0.576 rs11247706 chr1:28213983 G/C cg23691781 chr1:28212827 C1orf38 0.33 11.27 0.41 5.42e-27 Corneal astigmatism; BRCA cis rs7950696 1 rs7950696 chr11:47481533 T/C cg20307385 chr11:47447363 PSMC3 0.45 10.11 0.37 2.07e-22 Platelet count; BRCA cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg04586622 chr2:25135609 ADCY3 0.45 10.96 0.4 9.9e-26 Body mass index; BRCA cis rs6963495 0.818 rs73192105 chr7:105167945 T/C cg19920283 chr7:105172520 RINT1 0.59 9.43 0.35 7.47e-20 Bipolar disorder (body mass index interaction); BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.42e-19 Tonsillectomy; BRCA cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs453301 0.631 rs17700611 chr8:8793654 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -9.73 -0.36 5.76e-21 Joint mobility (Beighton score); BRCA cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.17 0.31 1.67e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2191566 0.576 rs420355 chr19:44495325 C/T cg20607764 chr19:44506953 ZNF230 0.37 8.03 0.3 4.64e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs113835537 0.529 rs2305533 chr11:66298623 A/C cg24851651 chr11:66362959 CCS 0.48 8.72 0.33 2.46e-17 Airway imaging phenotypes; BRCA cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.69 10.52 0.38 5.55e-24 Mean platelet volume; BRCA cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg03934865 chr2:198174659 NA -0.38 -8.26 -0.31 8.11e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7598759 0.679 rs6437018 chr2:232327691 A/C cg19187155 chr2:232395269 NMUR1 0.37 7.92 0.3 1.04e-14 Noise-induced hearing loss; BRCA cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg09184832 chr6:79620586 NA -0.49 -10.52 -0.38 5.45e-24 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.768 rs458185 chr6:109524074 A/G cg21918786 chr6:109611834 NA -0.35 -9.26 -0.34 3.09e-19 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg27347728 chr4:17578864 LAP3 0.45 8.84 0.33 9.43e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10267417 0.603 rs10233354 chr7:19895372 C/T cg05791153 chr7:19748676 TWISTNB 0.47 9.04 0.34 1.9e-18 Night sleep phenotypes; BRCA cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg26384229 chr12:38710491 ALG10B 0.74 17.65 0.57 4.53e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs2153535 0.580 rs9392224 chr6:8472614 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs2249625 0.545 rs9791273 chr6:72891016 G/T cg18830697 chr6:72922368 RIMS1 0.66 14.77 0.5 1.06e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 19.37 0.61 4.02e-66 Platelet count; BRCA cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg21918786 chr6:109611834 NA 0.45 12.09 0.43 1.92e-30 Reticulocyte fraction of red cells; BRCA cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg22834771 chr12:69754056 YEATS4 -0.43 -10.63 -0.39 2.04e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs9875589 0.509 rs6783645 chr3:14024542 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.89 0.33 6.41e-18 Ovarian reserve; BRCA cis rs7903847 0.642 rs12359257 chr10:99136359 A/T cg20016023 chr10:99160130 RRP12 -0.26 -8.04 -0.3 4.29e-15 Granulocyte percentage of myeloid white cells; BRCA trans rs7824557 0.836 rs1435278 chr8:11123029 G/T cg08975724 chr8:8085496 FLJ10661 -0.45 -8.41 -0.32 2.73e-16 Retinal vascular caliber; BRCA cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg04455712 chr21:45112962 RRP1B -0.42 -10.84 -0.39 2.88e-25 Mean corpuscular volume; BRCA cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg03146154 chr1:46216737 IPP 0.46 10.38 0.38 2.03e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg15103426 chr22:29168792 CCDC117 -0.46 -11.32 -0.41 3.43e-27 Red cell distribution width; BRCA cis rs4845875 0.513 rs198397 chr1:11883332 A/G cg24844545 chr1:11908347 NPPA -0.31 -8.29 -0.31 6.59e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6087990 0.966 rs1883730 chr20:31337487 T/A cg13636640 chr20:31349939 DNMT3B 0.77 25.09 0.7 3.37e-97 Ulcerative colitis; BRCA cis rs7561273 0.586 rs7589717 chr2:24357463 G/A cg04809136 chr2:24300158 SF3B14 -0.4 -8.97 -0.33 3.37e-18 Quantitative traits; BRCA cis rs2070488 0.965 rs2300668 chr3:38540541 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -18.37 -0.59 7.45e-61 Electrocardiographic conduction measures; BRCA cis rs1555322 0.530 rs6060347 chr20:33874151 A/G cg03689076 chr20:33865952 NA 0.44 8.05 0.3 4.01e-15 Attention deficit hyperactivity disorder; BRCA cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg02734326 chr4:10020555 SLC2A9 0.42 9.07 0.34 1.43e-18 Bone mineral density; BRCA cis rs708547 0.836 rs1612191 chr4:57724320 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.48 -10.81 -0.39 3.96e-25 Response to bleomycin (chromatid breaks); BRCA cis rs28595532 0.920 rs114080496 chr4:119726372 C/T cg14228332 chr4:119757509 SEC24D 0.68 8.1 0.31 2.78e-15 Cannabis dependence symptom count; BRCA cis rs7520050 0.966 rs6701614 chr1:46309420 G/C cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.37e-21 Red blood cell count;Reticulocyte count; BRCA trans rs11039798 0.699 rs7120775 chr11:48266736 C/G cg15704280 chr7:45808275 SEPT13 0.52 7.86 0.3 1.62e-14 Axial length; BRCA cis rs7582180 0.627 rs4407265 chr2:101005846 C/G cg14675211 chr2:100938903 LONRF2 0.44 9.74 0.36 5.6e-21 Intelligence (multi-trait analysis); BRCA cis rs61931739 0.500 rs11053278 chr12:34555955 T/C cg06521331 chr12:34319734 NA -0.52 -10.27 -0.38 5.25e-23 Morning vs. evening chronotype; BRCA cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg22800045 chr5:56110881 MAP3K1 0.73 13.44 0.47 1.97e-36 Initial pursuit acceleration; BRCA cis rs10484885 0.878 rs111664889 chr6:90566427 G/T cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.47 -0.35 5.11e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4478858 0.735 rs6670067 chr1:31842947 C/T cg00250761 chr1:31883323 NA -0.32 -8.28 -0.31 7e-16 Alcohol dependence; BRCA cis rs1949733 0.523 rs55977448 chr4:8542918 G/T cg11789530 chr4:8429930 ACOX3 -0.55 -12.62 -0.45 9.65e-33 Response to antineoplastic agents; BRCA cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg11271282 chr2:238384023 NA -0.43 -7.92 -0.3 1.07e-14 Prostate cancer; BRCA cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.53 -7.88 -0.3 1.46e-14 Cerebrospinal P-tau181p levels; BRCA cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg08085267 chr17:45401833 C17orf57 0.67 14.61 0.5 6.47e-42 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs936229 0.654 rs762551 chr15:75041917 C/A cg10253484 chr15:75165896 SCAMP2 -0.52 -9.72 -0.36 6.6e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs60843830 1.000 rs3791223 chr2:222336 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.54 0.59 9.68e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs17384381 1.000 rs12743049 chr1:85897386 G/A cg16011679 chr1:85725395 C1orf52 0.53 8.26 0.31 8.7e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.85 18.9 0.6 1.31e-63 Smoking behavior; BRCA cis rs17401966 1.000 rs12130220 chr1:10359944 T/G cg15208524 chr1:10270712 KIF1B 0.37 8.27 0.31 7.77e-16 Hepatocellular carcinoma; BRCA cis rs7553864 0.614 rs1886634 chr1:87614821 C/T cg17420885 chr1:87600446 LOC339524 0.39 7.83 0.3 1.97e-14 Smoking behavior; BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.26 -0.44 3.58e-31 Gut microbiome composition (summer); BRCA cis rs7149337 0.805 rs71422017 chr14:51612417 A/T cg23942311 chr14:51606299 NA 0.45 13.31 0.47 7.73e-36 Cancer; BRCA trans rs11098499 0.743 rs10003567 chr4:120241674 C/T cg25214090 chr10:38739885 LOC399744 0.44 10.27 0.38 5.09e-23 Corneal astigmatism; BRCA cis rs10501293 0.956 rs11037235 chr11:43100381 G/C cg03447554 chr11:43094025 NA -0.46 -8.64 -0.32 4.47e-17 Cognitive performance; BRCA cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg17330251 chr7:94953956 PON1 -0.42 -8.87 -0.33 7.37e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg18132916 chr6:79620363 NA -0.48 -10.9 -0.4 1.71e-25 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.865 rs2389809 chr4:120377399 T/C cg25214090 chr10:38739885 LOC399744 0.54 12.59 0.45 1.29e-32 Corneal astigmatism; BRCA cis rs1568889 0.667 rs7123947 chr11:28399908 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.51 9.78 0.36 3.92e-21 Bipolar disorder; BRCA cis rs13053817 0.948 rs13058415 chr22:29848481 G/T cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.48 -8.93 -0.33 4.52e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs1799922 0.693 rs339088 chr7:128422986 A/G cg02354431 chr7:128423266 NA -0.36 -9.31 -0.35 1.98e-19 Primary tooth development (number of teeth);Primary tooth development (time to first tooth eruption); BRCA cis rs9287719 0.649 rs10188373 chr2:10718802 A/G cg00105475 chr2:10696890 NA 0.41 9.18 0.34 5.97e-19 Prostate cancer; BRCA cis rs6597981 0.604 rs7945912 chr11:750849 A/T cg17628894 chr11:804452 LRDD -0.25 -8.04 -0.3 4.43e-15 Breast cancer; BRCA cis rs7103648 0.669 rs12577383 chr11:47774238 C/T cg20307385 chr11:47447363 PSMC3 0.74 16.8 0.55 9.88e-53 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg20887711 chr4:1340912 KIAA1530 0.74 16.13 0.54 2.46e-49 Longevity; BRCA cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg21132104 chr15:45694354 SPATA5L1 0.74 16.29 0.54 3.85e-50 Homoarginine levels; BRCA cis rs9403521 1.000 rs12208927 chr6:143993634 A/G cg18240653 chr6:144019428 PHACTR2 -0.41 -8.18 -0.31 1.53e-15 Obesity-related traits; BRCA cis rs8062405 1.000 rs7498665 chr16:28883241 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504073 0.525 rs10081464 chr8:50058707 A/G cg00325661 chr8:49890786 NA 0.35 9.59 0.35 1.95e-20 Blood metabolite ratios; BRCA cis rs9443189 0.570 rs569731 chr6:76357593 G/A cg01950844 chr6:76311363 SENP6 0.83 13.39 0.47 3.38e-36 Prostate cancer; BRCA cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg09074113 chr2:20870087 GDF7 -0.33 -7.96 -0.3 7.69e-15 Abdominal aortic aneurysm; BRCA cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg09359103 chr1:154839909 KCNN3 -0.56 -14.62 -0.5 5.84e-42 Prostate cancer; BRCA cis rs13102973 0.965 rs9998499 chr4:135869362 G/A cg14419869 chr4:135874104 NA -0.58 -12.84 -0.45 1.02e-33 Subjective well-being; BRCA cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg00684032 chr4:1343700 KIAA1530 0.32 8.12 0.31 2.47e-15 Obesity-related traits; BRCA cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 11.47 0.41 7.63e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs11105298 0.891 rs1054807 chr12:89913419 C/T cg00757033 chr12:89920650 WDR51B 0.54 11.1 0.4 2.76e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7149337 0.836 rs11622116 chr14:51670744 C/T cg23942311 chr14:51606299 NA 0.42 12.02 0.43 3.96e-30 Cancer; BRCA cis rs3808502 0.605 rs11784572 chr8:11174484 C/G cg21775007 chr8:11205619 TDH -0.63 -14.02 -0.49 3.89e-39 Neuroticism; BRCA cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg03264133 chr6:25882463 NA 0.7 16.06 0.54 5.36e-49 Blood metabolite levels; BRCA cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06022373 chr22:39101656 GTPBP1 0.74 18.2 0.58 5.93e-60 Menopause (age at onset); BRCA cis rs7824557 0.734 rs2293856 chr8:11177447 C/T cg21775007 chr8:11205619 TDH 0.65 12.84 0.45 1.01e-33 Retinal vascular caliber; BRCA cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.18 -0.31 1.56e-15 Aortic root size; BRCA cis rs4819052 0.851 rs2877020 chr21:46658742 C/T cg06618935 chr21:46677482 NA -0.37 -7.94 -0.3 9e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 9.22e-23 Psoriasis; BRCA cis rs17539620 0.519 rs871071 chr6:154837667 T/C cg20019720 chr6:154832845 CNKSR3 0.56 13.11 0.46 5.95e-35 Lipoprotein (a) levels; BRCA cis rs2979489 0.945 rs11992441 chr8:30313649 A/G cg26383811 chr8:30366931 RBPMS 0.5 11.46 0.41 8.95e-28 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs10789491 1.000 rs1440487 chr1:47167075 C/T cg15501359 chr1:47185051 KIAA0494 -0.64 -18.03 -0.58 4.51e-59 Response to hepatitis C treatment; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03934478 chr11:495069 RNH1 0.82 11.93 0.43 9.54e-30 Body mass index; BRCA cis rs9341808 0.935 rs4706113 chr6:80839315 C/T cg08355045 chr6:80787529 NA 0.32 8.15 0.31 1.92e-15 Sitting height ratio; BRCA cis rs4363385 0.720 rs1134220 chr1:152976306 T/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.11e-18 Inflammatory skin disease; BRCA cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg02187348 chr16:89574699 SPG7 0.5 12.38 0.44 1e-31 Multiple myeloma (IgH translocation); BRCA cis rs7659604 0.643 rs6839054 chr4:122663628 C/T cg19748678 chr4:122722346 EXOSC9 0.42 8.75 0.33 1.89e-17 Type 2 diabetes; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg11952622 chr19:58962976 ZNF324B 0.42 8.68 0.32 3.22e-17 Uric acid clearance; BRCA cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg25427524 chr10:38739819 LOC399744 0.6 13.69 0.48 1.35e-37 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.56 11.39 0.41 1.66e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.767 rs1695815 chr7:65831344 A/G cg11764359 chr7:65958608 NA 0.8 19.53 0.61 6.05e-67 Aortic root size; BRCA cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg11952622 chr19:58962976 ZNF324B 0.51 10.65 0.39 1.69e-24 Uric acid clearance; BRCA cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg26597838 chr10:835615 NA 1.29 21.77 0.65 4.84e-79 Eosinophil percentage of granulocytes; BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg09060608 chr5:178986726 RUFY1 -0.44 -10.42 -0.38 1.44e-23 Lung cancer; BRCA cis rs17270561 0.609 rs12192077 chr6:25732794 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs12210905 0.688 rs72843177 chr6:27367414 A/G cg08851530 chr6:28072375 NA 0.84 8.27 0.31 7.64e-16 Hip circumference adjusted for BMI; BRCA trans rs7786808 0.544 rs6971888 chr7:158193835 G/A cg02030672 chr11:45687055 CHST1 -0.41 -9.15 -0.34 7.78e-19 Obesity-related traits; BRCA cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg08213375 chr14:104286397 PPP1R13B 0.66 18.7 0.59 1.49e-62 Schizophrenia; BRCA trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg25206134 chr2:45395956 NA 0.52 8.78 0.33 1.5e-17 Bipolar disorder; BRCA cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg01689657 chr7:91764605 CYP51A1 0.24 8.62 0.32 5.28e-17 Breast cancer; BRCA cis rs11711311 1.000 rs12637067 chr3:113527606 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.51 0.38 5.98e-24 IgG glycosylation; BRCA cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg23719950 chr11:63933701 MACROD1 -0.54 -9.05 -0.34 1.76e-18 Attention deficit hyperactivity disorder; BRCA cis rs9649213 0.614 rs12539761 chr7:98013839 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.58 -14.83 -0.51 5.42e-43 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.565 rs6436082 chr2:219639430 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.93 -0.4 1.27e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs7336332 0.598 rs1885988 chr13:28010262 C/T cg22138327 chr13:27999177 GTF3A -0.59 -10.29 -0.38 4.23e-23 Weight; BRCA cis rs1003719 0.667 rs2835606 chr21:38490851 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.52 10.91 0.4 1.56e-25 Eye color traits; BRCA cis rs72634258 0.554 rs1012477 chr1:7858135 C/G cg26816564 chr1:7831052 VAMP3 -0.63 -11.79 -0.42 3.48e-29 Inflammatory bowel disease; BRCA cis rs11190604 0.943 rs11190588 chr10:102273565 C/T cg07080220 chr10:102295463 HIF1AN 0.6 13.03 0.46 1.44e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2204008 0.837 rs11180549 chr12:38236950 A/G cg26384229 chr12:38710491 ALG10B 0.75 16.93 0.56 2.16e-53 Bladder cancer; BRCA cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg02079420 chr8:82753780 SNX16 0.31 8.33 0.31 5.07e-16 Diastolic blood pressure; BRCA cis rs1499972 0.941 rs62264774 chr3:117647906 C/G cg07612923 chr3:117604196 NA 0.6 8.11 0.31 2.57e-15 Schizophrenia; BRCA trans rs2204008 0.870 rs12369578 chr12:38444227 C/T cg06521331 chr12:34319734 NA -0.43 -7.82 -0.3 2.16e-14 Bladder cancer; BRCA cis rs701145 0.585 rs398512 chr3:153909988 T/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs7301826 0.571 rs4759788 chr12:131296314 T/C cg11011512 chr12:131303247 STX2 0.5 12.92 0.46 4.11e-34 Plasma plasminogen activator levels; BRCA cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg20503657 chr10:835505 NA 1.01 17.8 0.58 7.03e-58 Eosinophil percentage of granulocytes; BRCA cis rs6815814 0.861 rs28690449 chr4:38789132 C/T cg06935464 chr4:38784597 TLR10 0.49 10.06 0.37 3.39e-22 Breast cancer; BRCA cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg06808227 chr14:105710500 BRF1 -0.8 -16.05 -0.54 6.1e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg24675658 chr1:53192096 ZYG11B -0.64 -14.07 -0.49 2.43e-39 Monocyte count; BRCA cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg11530693 chr1:120165357 ZNF697 0.61 14.5 0.5 2.07e-41 Systemic lupus erythematosus; BRCA cis rs965469 1.000 rs6051792 chr20:3343519 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.52 -0.38 5.66e-24 IFN-related cytopenia; BRCA trans rs7647973 0.593 rs7620848 chr3:49828021 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.4 8.13 0.31 2.22e-15 Menarche (age at onset); BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.74 -12.86 -0.45 8e-34 Gut microbiome composition (summer); BRCA cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg06108461 chr20:60628389 TAF4 -1.01 -23.06 -0.67 4.48e-86 Body mass index; BRCA trans rs61931739 1.000 rs1852223 chr12:34013251 C/T cg26384229 chr12:38710491 ALG10B -0.41 -9.28 -0.34 2.5e-19 Morning vs. evening chronotype; BRCA cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.21 -0.43 5.77e-31 Tonsillectomy; BRCA cis rs4664304 0.966 rs925407 chr2:160767502 A/C cg18514922 chr2:160761262 LY75 -0.39 -8.96 -0.33 3.62e-18 Crohn's disease;Inflammatory bowel disease; BRCA cis rs3806843 0.808 rs6893708 chr5:140125922 T/C cg26395211 chr5:140044315 WDR55 0.35 7.95 0.3 8.39e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg01689657 chr7:91764605 CYP51A1 -0.22 -7.99 -0.3 6.12e-15 Breast cancer; BRCA cis rs36051895 0.695 rs7851556 chr9:5022807 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.55 -0.32 8.91e-17 Pediatric autoimmune diseases; BRCA cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.4 -0.35 9.35e-20 Lobe attachment (rater-scored or self-reported); BRCA trans rs2797160 0.602 rs4897150 chr6:125985540 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.44 -10.06 -0.37 3.2800000000000002e-22 Endometrial cancer; BRCA cis rs7786877 0.761 rs11772705 chr7:100298904 T/C cg16850897 chr7:100343110 ZAN -0.49 -11.09 -0.4 2.81e-26 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg09467607 chr2:36825704 FEZ2 0.62 15.18 0.51 1.1e-44 Height; BRCA cis rs3858526 1.000 rs3858526 chr11:5959757 A/C cg25319279 chr11:5960081 NA -0.4 -8.2 -0.31 1.37e-15 DNA methylation (variation); BRCA cis rs7646881 1.000 rs7646881 chr3:158453279 C/A cg19483011 chr3:158453295 NA -0.49 -9.32 -0.35 1.81e-19 Tetralogy of Fallot; BRCA cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg02297831 chr4:17616191 MED28 0.35 8.17 0.31 1.62e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs919433 0.647 rs13404366 chr2:198522632 A/G cg00792783 chr2:198669748 PLCL1 0.37 8.47 0.32 1.67e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7845219 0.539 rs10441538 chr8:95868608 G/A cg16049864 chr8:95962084 TP53INP1 -0.39 -9.13 -0.34 9.11e-19 Type 2 diabetes; BRCA cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA cis rs2243480 1.000 rs6460260 chr7:65215455 T/C cg18252515 chr7:66147081 NA 0.91 13.02 0.46 1.61e-34 Diabetic kidney disease; BRCA cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg12219531 chr12:120966889 COQ5 -0.55 -11.71 -0.42 7.9e-29 High light scatter reticulocyte count; BRCA cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.52e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 1.000 rs62037365 chr16:28868962 C/G cg16576597 chr16:28551801 NUPR1 0.29 8.19 0.31 1.4e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs9858542 0.953 rs34588335 chr3:49407660 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.24 -0.34 3.75e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg15704280 chr7:45808275 SEPT13 -1.01 -32.47 -0.79 2.47e-137 Height; BRCA cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.07 0.37 3.1e-22 Electroencephalogram traits; BRCA cis rs921968 0.510 rs620887 chr2:219465594 C/A cg02176678 chr2:219576539 TTLL4 0.47 12.16 0.43 9.04e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs6028335 0.610 rs12626028 chr20:37553900 G/C cg16355469 chr20:37678765 NA 0.45 8.1 0.31 2.84e-15 Alcohol and nicotine co-dependence; BRCA cis rs11098499 0.865 rs28845498 chr4:120405186 G/A cg09307838 chr4:120376055 NA 0.72 15.28 0.52 3.69e-45 Corneal astigmatism; BRCA cis rs6684428 0.706 rs10493183 chr1:56333648 T/C cg11651538 chr1:56320950 NA -0.49 -8.47 -0.32 1.69e-16 Airflow obstruction; BRCA cis rs6782228 0.675 rs6806687 chr3:128391789 C/T cg16766828 chr3:128327626 NA 0.4 9.21 0.34 4.49e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs8062405 1.000 rs28403629 chr16:28854769 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.4e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.85 -0.53 6.02e-48 Systemic lupus erythematosus; BRCA cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg10621924 chr7:39171070 POU6F2 0.38 7.89 0.3 1.27e-14 IgG glycosylation; BRCA cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg14196790 chr5:131705035 SLC22A5 -0.42 -10.16 -0.37 1.39e-22 Breast cancer;Mosquito bite size; BRCA cis rs7927592 0.956 rs10896343 chr11:68317860 G/C cg20283391 chr11:68216788 NA -0.43 -8.38 -0.31 3.31e-16 Total body bone mineral density; BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26314531 chr2:26401878 FAM59B -0.89 -15.41 -0.52 8.82e-46 Gut microbiome composition (summer); BRCA cis rs17253792 0.822 rs75232282 chr14:56067290 G/C cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs514406 0.708 rs546334 chr1:53326210 T/C cg08859206 chr1:53392774 SCP2 -0.6 -13.09 -0.46 7.75e-35 Monocyte count; BRCA cis rs11608355 0.545 rs34737994 chr12:109901621 C/T cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs6973256 0.897 rs2066924 chr7:133338462 C/A cg07491979 chr7:133331646 EXOC4 -0.39 -9.01 -0.34 2.41e-18 Intelligence (multi-trait analysis); BRCA cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg08000102 chr2:233561755 GIGYF2 0.64 13.8 0.48 4.01e-38 Coronary artery disease; BRCA cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg19628046 chr18:33552617 C18orf21 0.54 11.15 0.4 1.69e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg05863683 chr7:1912471 MAD1L1 -0.35 -8.28 -0.31 7.23e-16 Bipolar disorder and schizophrenia; BRCA cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg02153584 chr22:29168773 CCDC117 0.51 10.72 0.39 8.74e-25 Lymphocyte counts; BRCA cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs524281 0.861 rs11227403 chr11:65858428 T/C cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4.15e-15 Electroencephalogram traits; BRCA cis rs7524258 0.867 rs916392 chr1:7271930 T/C cg07173049 chr1:7289937 CAMTA1 0.55 13.21 0.46 2.04e-35 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs6546550 0.835 rs13002091 chr2:70118388 C/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.55 -0.42 3.72e-28 Prevalent atrial fibrillation; BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -11.85 -0.42 2e-29 Tonsillectomy; BRCA trans rs17685 0.753 rs6951808 chr7:75772413 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4727027 0.727 rs1568944 chr7:148873497 A/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.44 9.99 0.37 6.37e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs72781680 0.611 rs72797819 chr2:24351141 T/G cg06627628 chr2:24431161 ITSN2 -0.56 -8.87 -0.33 7.52e-18 Lymphocyte counts; BRCA cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.31 -0.35 2.04e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs57590327 0.555 rs3772909 chr3:81707264 T/C cg07356753 chr3:81810745 GBE1 -0.43 -9.89 -0.36 1.43e-21 Extraversion; BRCA cis rs7927592 0.913 rs2236708 chr11:68378045 G/A cg20283391 chr11:68216788 NA -0.46 -9.19 -0.34 5.49e-19 Total body bone mineral density; BRCA cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg01877450 chr7:97915802 BRI3 -0.37 -8.29 -0.31 6.85e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs6089829 0.851 rs6089827 chr20:61668845 C/T cg03213289 chr20:61660250 NA 0.62 16.22 0.54 8.55e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs427394 1.000 rs182135 chr5:6747453 G/A cg10857441 chr5:6722123 POLS -0.31 -10.33 -0.38 3.14e-23 Menopause (age at onset); BRCA cis rs7917772 0.582 rs7091252 chr10:104328859 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg01877450 chr7:97915802 BRI3 -0.36 -8.15 -0.31 1.99e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs9393777 0.502 rs3823427 chr6:27256346 G/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.31 -0.31 5.87e-16 Intelligence (multi-trait analysis); BRCA cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg24675658 chr1:53192096 ZYG11B 0.68 14.69 0.5 2.61e-42 Monocyte count; BRCA cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg08859206 chr1:53392774 SCP2 0.49 10.84 0.39 3e-25 Monocyte count; BRCA cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.51 0.32 1.19e-16 Mean platelet volume; BRCA cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15506890 chr2:3487001 NA -0.58 -13.21 -0.46 2.15e-35 Neurofibrillary tangles; BRCA cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.09 0.49 1.96e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.65 0.32 4.01e-17 Rheumatoid arthritis; BRCA cis rs34779708 0.931 rs59418206 chr10:35331624 G/A cg03585969 chr10:35415529 CREM 0.56 11.6 0.42 2.32e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6066835 1.000 rs2223684 chr20:47354880 A/C cg18078177 chr20:47281410 PREX1 0.65 8.41 0.32 2.76e-16 Multiple myeloma; BRCA cis rs9858542 0.953 rs9841110 chr3:49492481 C/G cg03060546 chr3:49711283 APEH -0.51 -10.03 -0.37 4.39e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg06784218 chr1:46089804 CCDC17 0.5 11.89 0.43 1.4e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs28493229 0.708 rs73546845 chr19:41158717 C/T cg21869046 chr19:41225005 ITPKC 0.32 9.17 0.34 6.31e-19 Kawasaki disease; BRCA cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg01017244 chr2:74357527 NA 0.6 13.49 0.47 1.11e-36 Gestational age at birth (maternal effect); BRCA cis rs875971 0.508 rs10950045 chr7:66066373 T/C cg18876405 chr7:65276391 NA -0.57 -13.62 -0.47 3e-37 Aortic root size; BRCA cis rs2479724 0.846 rs2254474 chr6:41843044 T/G cg17623882 chr6:41773611 USP49 -0.34 -9.13 -0.34 8.98e-19 Menarche (age at onset); BRCA cis rs2075371 1.000 rs2598294 chr7:133991690 C/T cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.7800000000000005e-38 Mean platelet volume; BRCA cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg15103426 chr22:29168792 CCDC117 -0.49 -11.26 -0.41 5.71e-27 Lymphocyte counts; BRCA cis rs7580658 0.545 rs13001179 chr2:127952193 A/C cg16751203 chr2:127950803 CYP27C1 0.28 8.19 0.31 1.44e-15 Protein C levels; BRCA cis rs11718455 0.921 rs35872933 chr3:44028515 T/G cg08738300 chr3:44038990 NA 0.47 8.82 0.33 1.12e-17 Coronary artery disease; BRCA cis rs4268898 0.571 rs1986478 chr2:24468545 G/A cg06627628 chr2:24431161 ITSN2 -0.79 -15.05 -0.51 5.04e-44 Asthma; BRCA trans rs1325195 0.920 rs2816183 chr1:179116474 C/G cg11624085 chr17:8464688 MYH10 0.26 7.98 0.3 7.01e-15 IgE grass sensitization; BRCA cis rs9287719 0.935 rs6751075 chr2:10723546 C/G cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.46e-23 Prostate cancer; BRCA cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg11833968 chr6:79620685 NA -0.4 -9.05 -0.34 1.75e-18 Intelligence (multi-trait analysis); BRCA cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg07952391 chr2:88470173 THNSL2 0.67 9.2 0.34 5.22e-19 Plasma clusterin levels; BRCA cis rs2282802 0.651 rs10060071 chr5:139599097 T/C cg26211634 chr5:139558579 C5orf32 0.34 8.41 0.32 2.75e-16 Intelligence (multi-trait analysis); BRCA cis rs3936840 0.565 rs8011721 chr14:102986388 C/G cg18135206 chr14:102964638 TECPR2 -0.49 -9.96 -0.37 7.88e-22 Plateletcrit; BRCA cis rs62229266 0.835 rs998384 chr21:37445526 G/C cg12218747 chr21:37451666 NA -0.38 -8.9 -0.33 5.67e-18 Mitral valve prolapse; BRCA cis rs3768617 0.510 rs2027078 chr1:183073478 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 16.99 0.56 1.09e-53 Fuchs's corneal dystrophy; BRCA cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg23711669 chr6:146136114 FBXO30 -0.79 -18.82 -0.6 3.37e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg17173187 chr15:85201210 NMB 0.42 8.85 0.33 8.83e-18 Schizophrenia; BRCA cis rs8114671 0.562 rs6120758 chr20:33492523 C/T cg07148914 chr20:33460835 GGT7 0.38 8.62 0.32 5.1e-17 Height; BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.41 8.98 0.33 3.01e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg12667521 chr19:29218732 NA 0.47 8.71 0.33 2.55e-17 Methadone dose in opioid dependence; BRCA cis rs7246657 0.722 rs2972430 chr19:38182111 C/T cg23950597 chr19:37808831 NA 0.51 8.69 0.33 2.96e-17 Coronary artery calcification; BRCA cis rs11608355 0.515 rs4766605 chr12:109895636 C/A cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg18230493 chr5:56204884 C5orf35 -0.75 -14.81 -0.51 7.42e-43 Initial pursuit acceleration; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.59 -10.38 -0.38 1.89e-23 Gut microbiome composition (summer); BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg21782813 chr7:2030301 MAD1L1 0.43 12.34 0.44 1.53e-31 Bipolar disorder and schizophrenia; BRCA cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg25319279 chr11:5960081 NA -0.43 -8.39 -0.32 3e-16 DNA methylation (variation); BRCA cis rs7582180 0.629 rs4851308 chr2:100971865 C/A cg14675211 chr2:100938903 LONRF2 0.51 11.41 0.41 1.39e-27 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg08888203 chr3:10149979 C3orf24 0.67 14.09 0.49 1.93e-39 Alzheimer's disease; BRCA cis rs6714710 0.580 rs35564270 chr2:98602165 A/G cg26665480 chr2:98280029 ACTR1B 0.59 13.43 0.47 2.03e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs28735056 0.967 rs11660941 chr18:77630600 G/C cg20368463 chr18:77673604 PQLC1 -0.34 -8.11 -0.31 2.67e-15 Schizophrenia; BRCA cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs6831352 0.734 rs2602857 chr4:100030318 G/A cg13256891 chr4:100009986 ADH5 0.5 10.49 0.38 7.61e-24 Alcohol dependence; BRCA cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.67 13.7 0.48 1.16e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10911363 0.592 rs2782411 chr1:183476929 G/A cg09173681 chr1:183549694 NCF2 0.53 11.12 0.4 2.19e-26 Systemic lupus erythematosus; BRCA cis rs11997175 0.704 rs11775534 chr8:33695232 G/A ch.8.33884649F chr8:33765107 NA 0.35 8.32 0.31 5.3e-16 Body mass index; BRCA trans rs11976180 1.000 rs1533268 chr7:143766358 A/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs41005 1.000 rs41007 chr2:8109043 A/G cg03155496 chr2:8117019 LOC339788 -0.59 -15.95 -0.53 1.88e-48 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs4722585 0.533 rs2049843 chr7:26196963 G/A cg07876897 chr7:26191696 NFE2L3 0.4 8.64 0.32 4.59e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg08975724 chr8:8085496 FLJ10661 -0.38 -7.94 -0.3 8.88e-15 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs4688759 0.719 rs73079018 chr3:49875327 T/C cg00383909 chr3:49044727 WDR6 0.86 12.51 0.44 2.83e-32 Blood protein levels; BRCA cis rs6570726 0.577 rs406868 chr6:145809983 C/T cg05347473 chr6:146136440 FBXO30 0.58 11.0 0.4 6.64e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs6973256 0.569 rs6944149 chr7:133381365 A/C cg07491979 chr7:133331646 EXOC4 0.35 7.93 0.3 9.85e-15 Intelligence (multi-trait analysis); BRCA trans rs637571 0.522 rs28578718 chr11:65748400 C/A cg17712092 chr4:129076599 LARP1B 0.56 13.65 0.48 2.06e-37 Eosinophil percentage of white cells; BRCA trans rs116095464 0.558 rs10065584 chr5:253997 G/A cg00938859 chr5:1591904 SDHAP3 0.66 9.1 0.34 1.14e-18 Breast cancer; BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg08470875 chr2:26401718 FAM59B 0.76 11.99 0.43 5.11e-30 Gut microbiome composition (summer); BRCA cis rs7851660 0.548 rs1156850 chr9:100573164 G/A cg13688889 chr9:100608707 NA -0.5 -11.4 -0.41 1.55e-27 Strep throat; BRCA cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg15017067 chr4:17643749 FAM184B 0.27 8.07 0.3 3.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs317689 0.718 rs645026 chr12:69757931 G/A cg14784868 chr12:69753453 YEATS4 0.46 8.96 0.33 3.63e-18 Response to diuretic therapy; BRCA cis rs17818399 0.645 rs35870739 chr2:46784231 A/C cg02822958 chr2:46747628 ATP6V1E2 0.61 11.22 0.41 8.22e-27 Height; BRCA cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.42 -0.32 2.55e-16 Menarche (age at onset); BRCA cis rs2637266 0.935 rs2583049 chr10:78403962 T/C cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs478304 0.903 rs12293022 chr11:65531698 C/T cg08755490 chr11:65554678 OVOL1 0.52 10.88 0.4 2.11e-25 Acne (severe); BRCA trans rs877282 0.583 rs11253425 chr10:815173 G/A cg22713356 chr15:30763199 NA 1.03 17.01 0.56 8.9e-54 Uric acid levels; BRCA cis rs7264396 0.690 rs2425170 chr20:34442672 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.69 -13.95 -0.48 8.1e-39 Total cholesterol levels; BRCA cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.14 0.37 1.62e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7635838 0.617 rs184700 chr3:11293061 A/G cg00170343 chr3:11313890 ATG7 0.4 8.1 0.31 2.77e-15 HDL cholesterol; BRCA cis rs7246657 0.943 rs7252346 chr19:37914682 G/A cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA cis rs58785573 0.624 rs2126526 chr4:38618689 A/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.45 9.28 0.34 2.7e-19 Lymphocyte percentage of white cells; BRCA cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg01256987 chr12:42539512 GXYLT1 -0.57 -11.69 -0.42 9.75e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg07636037 chr3:49044803 WDR6 0.93 26.85 0.73 6.92e-107 Parkinson's disease; BRCA cis rs35306767 0.903 rs12254002 chr10:929133 A/G cg26597838 chr10:835615 NA -0.99 -18.27 -0.59 2.66e-60 Eosinophil percentage of granulocytes; BRCA trans rs62103177 0.525 rs4799116 chr18:77736735 A/G cg05926928 chr17:57297772 GDPD1 -0.57 -8.83 -0.33 1.02e-17 Opioid sensitivity; BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00149659 chr3:10157352 C3orf10 0.65 9.86 0.36 1.84e-21 Alzheimer's disease; BRCA trans rs11098499 0.863 rs2291185 chr4:120434833 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.14 0.31 2.07e-15 Corneal astigmatism; BRCA cis rs11763147 1 rs11763147 chr7:65326821 C/T cg18876405 chr7:65276391 NA -0.68 -17.96 -0.58 1.09e-58 Corneal structure; BRCA cis rs11051970 0.879 rs2171373 chr12:32575777 C/T cg02745156 chr12:32552066 NA 0.27 8.99 0.33 2.86e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg18132916 chr6:79620363 NA -0.45 -10.45 -0.38 1.02e-23 Intelligence (multi-trait analysis); BRCA trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21582582 chr3:182698605 DCUN1D1 -0.38 -9.98 -0.37 6.5600000000000005e-22 Intelligence (multi-trait analysis); BRCA cis rs7258465 1.000 rs10411009 chr19:18606266 A/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.17 -0.31 1.66e-15 Breast cancer; BRCA cis rs4820294 0.669 rs7287340 chr22:38054325 C/T cg21798802 chr22:38057573 PDXP 0.29 7.9 0.3 1.23e-14 Fat distribution (HIV); BRCA cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 -0.33 -11.18 -0.4 1.29e-26 Systemic lupus erythematosus; BRCA trans rs79976124 0.797 rs77895756 chr6:66626782 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.6 0.39 2.78e-24 Type 2 diabetes; BRCA cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg11764359 chr7:65958608 NA -0.79 -19.35 -0.61 5.48e-66 Aortic root size; BRCA cis rs9818758 0.607 rs9837625 chr3:49215966 C/T cg00383909 chr3:49044727 WDR6 0.74 12.49 0.44 3.58e-32 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs17401966 0.931 rs4846205 chr1:10310214 A/T cg03954927 chr1:10346856 KIF1B 0.48 15.12 0.51 2.19e-44 Hepatocellular carcinoma; BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg14582100 chr15:45693742 SPATA5L1 0.38 12.35 0.44 1.4e-31 Homoarginine levels; BRCA cis rs12995491 0.933 rs7590305 chr2:88513131 C/T cg04511125 chr2:88470314 THNSL2 -0.47 -9.51 -0.35 3.96e-20 Response to metformin (IC50); BRCA cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.48 0.47 1.24e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3768617 0.782 rs10911211 chr1:183022299 A/T ch.1.3577855R chr1:183094577 LAMC1 0.44 9.7 0.36 7.76e-21 Fuchs's corneal dystrophy; BRCA cis rs801193 0.904 rs4718405 chr7:66254646 A/G cg18876405 chr7:65276391 NA 0.57 14.23 0.49 4.22e-40 Aortic root size; BRCA cis rs208520 0.690 rs1563929 chr6:66702108 G/A cg07460842 chr6:66804631 NA 0.97 19.56 0.61 3.88e-67 Exhaled nitric oxide output; BRCA cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg16680214 chr1:154839983 KCNN3 -0.4 -10.96 -0.4 9.71e-26 Prostate cancer; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg18402987 chr7:1209562 NA 0.67 11.69 0.42 9.92e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9487051 0.768 rs1269172 chr6:109522080 G/C cg01475377 chr6:109611718 NA -0.45 -11.4 -0.41 1.58e-27 Reticulocyte fraction of red cells; BRCA cis rs7103648 0.695 rs12577643 chr11:47467172 A/T cg03711944 chr11:47377212 SPI1 -0.36 -8.53 -0.32 1.1e-16 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg12311346 chr5:56204834 C5orf35 -0.8 -15.97 -0.53 1.43e-48 Initial pursuit acceleration; BRCA cis rs477692 0.905 rs544217 chr10:131420584 A/G cg05714579 chr10:131428358 MGMT 0.56 13.85 0.48 2.53e-38 Response to temozolomide; BRCA cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg12311346 chr5:56204834 C5orf35 0.61 12.73 0.45 3.11e-33 Initial pursuit acceleration; BRCA trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg27147174 chr7:100797783 AP1S1 -0.54 -10.87 -0.4 2.38e-25 Life satisfaction; BRCA cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg14689365 chr7:158441557 NCAPG2 -0.42 -8.78 -0.33 1.54e-17 Height; BRCA cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.15e-15 Alzheimer's disease (late onset); BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg00149659 chr3:10157352 C3orf10 0.71 12.36 0.44 1.34e-31 Alzheimer's disease; BRCA cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg23173402 chr1:227635558 NA 0.51 9.21 0.34 4.66e-19 Major depressive disorder; BRCA cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11890956 chr21:40555474 PSMG1 1.01 25.14 0.71 1.75e-97 Cognitive function; BRCA cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg08917208 chr2:24149416 ATAD2B 1.07 14.82 0.51 5.99e-43 Lymphocyte counts; BRCA cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg10578991 chr7:12443926 VWDE -0.49 -8.24 -0.31 1.01e-15 Coronary artery disease; BRCA trans rs6479891 0.915 rs4281380 chr10:64987698 C/A cg14819942 chr15:35414228 NA -0.35 -8.6 -0.32 6.07e-17 Arthritis (juvenile idiopathic); BRCA cis rs10880689 1 rs10880689 chr12:37930102 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.34 0.31 4.59e-16 Resting heart rate; BRCA trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.18 -0.49 7.04e-40 Extrinsic epigenetic age acceleration; BRCA trans rs9929218 1.000 rs13330350 chr16:68800849 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.93 -0.48 1.03e-38 Colorectal cancer; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs61931739 0.500 rs11053199 chr12:34450534 C/T cg06521331 chr12:34319734 NA 0.51 9.99 0.37 6.41e-22 Morning vs. evening chronotype; BRCA cis rs11098499 0.909 rs78332141 chr4:120375782 C/T cg09307838 chr4:120376055 NA 0.74 16.0 0.53 1.04e-48 Corneal astigmatism; BRCA trans rs11098499 0.687 rs71610270 chr4:120287436 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.87 0.3 1.47e-14 Corneal astigmatism; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg00106254 chr7:1943704 MAD1L1 -0.39 -10.58 -0.39 3.37e-24 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA trans rs11039798 0.588 rs10838970 chr11:48606267 G/T cg03929089 chr4:120376271 NA 0.49 8.18 0.31 1.59e-15 Axial length; BRCA cis rs12760731 0.720 rs10913544 chr1:178350980 C/T cg00404053 chr1:178313656 RASAL2 0.58 7.9 0.3 1.26e-14 Obesity-related traits; BRCA cis rs11168351 0.833 rs6580652 chr12:48447105 C/A cg24011408 chr12:48396354 COL2A1 -0.39 -7.89 -0.3 1.36e-14 Bipolar disorder and schizophrenia; BRCA cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg16339924 chr4:17578868 LAP3 0.6 14.62 0.5 5.83e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg01849466 chr14:104193079 ZFYVE21 0.46 10.46 0.38 9.71e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg21427119 chr20:30132790 HM13 -0.42 -8.92 -0.33 4.92e-18 Mean corpuscular hemoglobin; BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg00945666 chr1:160990265 F11R -0.3 -8.65 -0.32 4.27e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg24324837 chr19:49891574 CCDC155 0.48 8.67 0.32 3.42e-17 Multiple sclerosis; BRCA cis rs501916 0.796 rs75186419 chr15:48043934 G/A cg16110827 chr15:48056943 SEMA6D -0.43 -9.16 -0.34 7.02e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg21427119 chr20:30132790 HM13 -0.41 -8.67 -0.32 3.45e-17 Mean corpuscular hemoglobin; BRCA cis rs7264396 0.561 rs6058387 chr20:34568092 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -10.61 -0.39 2.41e-24 Total cholesterol levels; BRCA cis rs7246657 0.722 rs10406379 chr19:38036725 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.17 0.34 6.65e-19 Coronary artery calcification; BRCA cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.666 rs6597957 chr11:982294 T/A ch.11.42038R chr11:967971 AP2A2 0.5 15.42 0.52 7.98e-46 Alzheimer's disease (late onset); BRCA cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.14 0.31 2.08e-15 Parkinson's disease; BRCA cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg26384229 chr12:38710491 ALG10B -0.54 -13.47 -0.47 1.4e-36 Morning vs. evening chronotype; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg12419862 chr22:24373484 LOC391322 0.75 17.48 0.57 3.45e-56 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg00530320 chr1:46809349 NSUN4 0.48 9.47 0.35 5.28e-20 Menopause (age at onset); BRCA cis rs208520 0.690 rs12204512 chr6:66710486 C/T cg07460842 chr6:66804631 NA 0.97 19.41 0.61 2.42e-66 Exhaled nitric oxide output; BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg03188948 chr7:1209495 NA 0.42 8.21 0.31 1.2e-15 Longevity;Endometriosis; BRCA cis rs4727027 0.704 rs12704073 chr7:148905067 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.39 8.01 0.3 5.29e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10193935 0.901 rs997288 chr2:42525582 C/G cg27598129 chr2:42591480 NA -0.88 -14.57 -0.5 1.01e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg12641515 chr19:46296257 DMWD -0.39 -8.0 -0.3 5.91e-15 Coronary artery disease; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11141652 chr22:24348549 GSTTP1 -0.42 -8.68 -0.32 3.3e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00149659 chr3:10157352 C3orf10 0.7 12.42 0.44 6.99e-32 Alzheimer's disease; BRCA trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.63e-33 Extrinsic epigenetic age acceleration; BRCA cis rs7551345 0.653 rs16834266 chr1:31698668 C/T cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.17e-22 Schizophrenia; BRCA cis rs9807989 0.507 rs6706002 chr2:103006104 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.42 0.32 2.4e-16 Asthma; BRCA cis rs6987853 0.787 rs2974335 chr8:42417272 C/T cg09913449 chr8:42400586 C8orf40 0.42 9.38 0.35 1.11e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.41 0.5 5.54e-41 Colorectal cancer; BRCA cis rs919433 0.617 rs12619333 chr2:198567638 C/G cg00792783 chr2:198669748 PLCL1 -0.44 -9.77 -0.36 4.26e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.59 -12.26 -0.44 3.49e-31 Lymphocyte counts; BRCA cis rs10501293 0.703 rs4237640 chr11:42990542 G/A cg03447554 chr11:43094025 NA 0.42 7.92 0.3 1.02e-14 Cognitive performance; BRCA cis rs2288073 0.965 rs6545335 chr2:24422011 G/A cg26838691 chr2:24397539 C2orf84 -0.49 -8.87 -0.33 7.07e-18 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7707921 0.881 rs73136782 chr5:81443520 T/G cg15871215 chr5:81402204 ATG10 -0.4 -8.54 -0.32 1.02e-16 Breast cancer; BRCA cis rs921968 0.541 rs2710246 chr2:219533894 C/T cg10223061 chr2:219282414 VIL1 -0.27 -8.21 -0.31 1.21e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.58 8.02 0.3 5.12e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg22920501 chr2:26401640 FAM59B -0.6 -9.95 -0.37 8.57e-22 Gut microbiome composition (summer); BRCA cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg03433033 chr1:76189801 ACADM -0.6 -12.15 -0.43 1.08e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg05347473 chr6:146136440 FBXO30 0.39 7.93 0.3 9.59e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -8.93 -0.33 4.37e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs10751667 0.643 rs7396407 chr11:929374 A/T ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs10752881 1.000 rs10911185 chr1:182971747 G/C ch.1.3577855R chr1:183094577 LAMC1 0.64 17.04 0.56 5.99e-54 Colorectal cancer; BRCA cis rs4728302 0.869 rs7779370 chr7:133595702 T/C cg07491979 chr7:133331646 EXOC4 0.37 7.91 0.3 1.13e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg00814883 chr7:100076585 TSC22D4 -0.55 -10.74 -0.39 7.84e-25 Platelet count; BRCA cis rs1568889 1.000 rs66857704 chr11:28212346 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 13.28 0.47 9.78e-36 Bipolar disorder; BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.3 -0.44 2.46e-31 Alzheimer's disease; BRCA cis rs6138458 0.962 rs6036976 chr20:24901567 T/G cg06937882 chr20:24974362 C20orf3 0.44 8.38 0.31 3.34e-16 Blood protein levels; BRCA cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg24130564 chr14:104152367 KLC1 -0.34 -7.91 -0.3 1.15e-14 Body mass index; BRCA cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg12386194 chr3:101231763 SENP7 0.46 9.66 0.36 1.05e-20 Colorectal cancer; BRCA cis rs9815354 0.556 rs60966614 chr3:42005166 A/G cg03022575 chr3:42003672 ULK4 0.74 10.27 0.38 5.43e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg09658497 chr7:2847517 GNA12 -0.41 -8.63 -0.32 4.82e-17 Height; BRCA cis rs11098499 0.779 rs6815934 chr4:120267310 T/C cg09307838 chr4:120376055 NA 0.59 12.89 0.45 5.65e-34 Corneal astigmatism; BRCA cis rs4727443 1.000 rs6974373 chr7:99590893 C/G cg22004693 chr7:99632812 ZKSCAN1 0.39 8.89 0.33 6.05e-18 Interstitial lung disease; BRCA cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg18230493 chr5:56204884 C5orf35 0.4 8.09 0.3 2.91e-15 Coronary artery disease; BRCA cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg22862634 chr11:62369728 EML3;MTA2 0.54 10.92 0.4 1.45e-25 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg05863683 chr7:1912471 MAD1L1 0.38 8.41 0.32 2.77e-16 Bipolar disorder and schizophrenia; BRCA trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.82 -0.3 2.25e-14 Corneal astigmatism; BRCA cis rs7727544 0.709 rs272852 chr5:131688767 G/A cg07395648 chr5:131743802 NA -0.37 -9.22 -0.34 4.19e-19 Blood metabolite levels; BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg14820908 chr5:178986412 RUFY1 0.41 9.64 0.36 1.31e-20 Lung cancer; BRCA cis rs9287719 0.901 rs6432109 chr2:10736821 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs6772849 0.930 rs9873888 chr3:128360987 G/A cg16766828 chr3:128327626 NA -0.4 -8.77 -0.33 1.67e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs4363385 0.747 rs3806219 chr1:152972522 C/T cg24667326 chr1:152973720 SPRR3 0.35 9.84 0.36 2.19e-21 Inflammatory skin disease; BRCA cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg01256987 chr12:42539512 GXYLT1 -0.68 -16.26 -0.54 4.98e-50 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg03452623 chr4:187889614 NA 0.34 10.82 0.39 3.68e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7727544 0.647 rs72793280 chr5:131562900 C/T cg14196790 chr5:131705035 SLC22A5 0.42 10.75 0.39 6.98e-25 Blood metabolite levels; BRCA cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg06634786 chr22:41940651 POLR3H -0.55 -9.62 -0.36 1.52e-20 Vitiligo; BRCA cis rs35110281 0.720 rs162380 chr21:44925283 T/C cg04455712 chr21:45112962 RRP1B -0.4 -10.03 -0.37 4.45e-22 Mean corpuscular volume; BRCA cis rs68170813 0.559 rs17350182 chr7:106909637 T/A cg02696742 chr7:106810147 HBP1 -0.53 -8.53 -0.32 1.07e-16 Coronary artery disease; BRCA trans rs877282 0.853 rs12779017 chr10:763619 T/C cg22713356 chr15:30763199 NA 1.32 24.9 0.7 3.56e-96 Uric acid levels; BRCA cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.78 0.5 9.45e-43 Colorectal cancer; BRCA cis rs600231 0.706 rs10896016 chr11:65335705 C/T cg17120908 chr11:65337727 SSSCA1 0.53 9.69 0.36 8.6e-21 Bone mineral density; BRCA cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -12.78 -0.45 1.88e-33 Bipolar disorder; BRCA cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg01475377 chr6:109611718 NA -0.52 -13.27 -0.46 1.09e-35 Reticulocyte fraction of red cells; BRCA cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg21644426 chr2:191273491 MFSD6 0.46 11.62 0.42 1.93e-28 Pulse pressure; BRCA cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg11266682 chr4:10021025 SLC2A9 0.4 10.85 0.39 2.77e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg23029597 chr12:123009494 RSRC2 -0.6 -11.69 -0.42 9.17e-29 Body mass index; BRCA cis rs7851660 0.935 rs4460498 chr9:100620412 T/C cg13688889 chr9:100608707 NA -0.36 -8.78 -0.33 1.46e-17 Strep throat; BRCA cis rs12949688 0.870 rs9906591 chr17:55816832 T/C cg12582317 chr17:55822272 NA 0.32 8.05 0.3 4.01e-15 Schizophrenia; BRCA cis rs698833 0.886 rs4953086 chr2:44561532 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.54 11.23 0.41 7.59e-27 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs870825 0.616 rs79884757 chr4:185621454 A/G cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs9914988 0.887 rs4795464 chr17:27146497 G/C cg20469991 chr17:27169893 C17orf63 -0.44 -8.54 -0.32 9.95e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg27446573 chr6:127587934 RNF146 0.89 20.34 0.63 2.6e-71 Breast cancer; BRCA cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg21573476 chr21:45109991 RRP1B -0.34 -8.68 -0.32 3.23e-17 Mean corpuscular volume; BRCA cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg05234568 chr11:5960015 NA -0.48 -9.49 -0.35 4.69e-20 DNA methylation (variation); BRCA cis rs861020 0.771 rs629150 chr1:209998467 C/T cg05527609 chr1:210001259 C1orf107 0.82 19.15 0.6 6.01e-65 Orofacial clefts; BRCA cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -9.29 -0.34 2.49e-19 Personality dimensions; BRCA cis rs6878727 0.665 rs256852 chr5:123662671 A/C cg01806427 chr5:123737813 NA -0.35 -7.89 -0.3 1.36e-14 Breast cancer; BRCA cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.51e-36 High light scatter reticulocyte count; BRCA cis rs35110281 0.667 rs4819293 chr21:45125863 A/G cg04455712 chr21:45112962 RRP1B 0.45 11.05 0.4 4.46e-26 Mean corpuscular volume; BRCA cis rs7582180 0.638 rs7581011 chr2:100954659 A/G cg14675211 chr2:100938903 LONRF2 -0.43 -9.69 -0.36 7.98e-21 Intelligence (multi-trait analysis); BRCA cis rs250677 0.687 rs42364 chr5:148438858 T/A cg23229984 chr5:148520753 ABLIM3 0.35 8.77 0.33 1.66e-17 Breast cancer; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg09177884 chr7:1199841 ZFAND2A -0.61 -15.19 -0.51 1.08e-44 Longevity;Endometriosis; BRCA cis rs1182196 0.533 rs2527521 chr7:2904928 A/G cg13628971 chr7:2884303 GNA12 -0.4 -9.29 -0.35 2.3e-19 Plateletcrit; BRCA trans rs1997103 1.000 rs6958664 chr7:55404958 T/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4664304 0.658 rs2667008 chr2:160865095 C/T cg01092293 chr2:160761427 LY75 -0.36 -8.75 -0.33 1.86e-17 Crohn's disease;Inflammatory bowel disease; BRCA cis rs5753037 0.653 rs140123 chr22:30143206 A/G cg01021169 chr22:30184971 ASCC2 0.35 8.19 0.31 1.39e-15 Type 1 diabetes; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg15112475 chr7:1198522 ZFAND2A -0.56 -12.86 -0.45 8.08e-34 Longevity;Endometriosis; BRCA cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg08822215 chr16:89438651 ANKRD11 -0.4 -8.52 -0.32 1.15e-16 Multiple myeloma (IgH translocation); BRCA cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg24829409 chr8:58192753 C8orf71 0.47 9.1 0.34 1.15e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.68 0.5 3.1e-42 Motion sickness; BRCA cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg05025164 chr4:1340916 KIAA1530 0.77 15.82 0.53 8.2e-48 Longevity; BRCA cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg08213375 chr14:104286397 PPP1R13B 0.41 8.94 0.33 4.26e-18 Reticulocyte count; BRCA cis rs2979489 0.740 rs17554408 chr8:30427531 A/G cg26383811 chr8:30366931 RBPMS 0.51 11.57 0.42 3.09e-28 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA trans rs3733585 0.673 rs4467563 chr4:9953460 A/T cg26043149 chr18:55253948 FECH -0.37 -8.17 -0.31 1.59e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs9291683 0.527 rs3822241 chr4:10094931 G/A cg26043149 chr18:55253948 FECH -0.41 -8.73 -0.33 2.19e-17 Bone mineral density; BRCA cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg03146154 chr1:46216737 IPP 0.43 9.22 0.34 4.12e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11651000 0.947 rs59216876 chr17:45832965 G/A cg03474202 chr17:45855739 NA -0.43 -7.83 -0.3 2.06e-14 IgG glycosylation; BRCA cis rs12541635 0.639 rs1032545 chr8:107005825 C/T cg10147462 chr8:107024639 NA 0.4 10.78 0.39 5.05e-25 Age of smoking initiation; BRCA cis rs68170813 0.641 rs4730228 chr7:106904077 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.54 -0.32 9.46e-17 Coronary artery disease; BRCA cis rs68170813 0.559 rs11773514 chr7:106958469 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.56 -0.32 8.57e-17 Coronary artery disease; BRCA cis rs61990749 0.597 rs176980 chr14:78198449 C/G cg02301378 chr14:78227641 SNW1;C14orf178 -0.66 -10.58 -0.39 3.19e-24 Fibroblast growth factor basic levels; BRCA cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg01528321 chr10:82214614 TSPAN14 0.64 14.47 0.5 3e-41 Post bronchodilator FEV1; BRCA cis rs11758351 1.000 rs16891378 chr6:26188864 A/G cg01420254 chr6:26195488 NA 0.58 9.06 0.34 1.53e-18 Gout;Renal underexcretion gout; BRCA cis rs796364 0.951 rs281769 chr2:200809709 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.35 0.47 4.99e-36 Schizophrenia; BRCA cis rs72781680 0.665 rs2675356 chr2:24074734 C/T cg08917208 chr2:24149416 ATAD2B 0.6 10.25 0.38 6.06e-23 Lymphocyte counts; BRCA cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.42 -0.32 2.4e-16 Monocyte percentage of white cells; BRCA cis rs6435161 0.879 rs72928949 chr2:203570761 G/C cg18429434 chr2:203499731 FAM117B -0.45 -8.86 -0.33 7.61e-18 Total cholesterol levels; BRCA cis rs8005677 1.000 rs11157930 chr14:23403171 T/G cg01529538 chr14:23388837 RBM23 0.41 11.03 0.4 5.25e-26 Cognitive ability (multi-trait analysis); BRCA cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg16339924 chr4:17578868 LAP3 -0.53 -12.68 -0.45 5.22e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9649213 0.614 rs9641236 chr7:97998124 T/A cg09267113 chr7:98030324 BAIAP2L1 -0.58 -14.76 -0.5 1.17e-42 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg08917208 chr2:24149416 ATAD2B 0.89 12.98 0.46 2.32e-34 Lymphocyte counts; BRCA cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg18876405 chr7:65276391 NA -0.71 -18.53 -0.59 1.11e-61 Aortic root size; BRCA cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg05985134 chr18:33552581 C18orf21 0.69 13.25 0.46 1.44e-35 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6964587 1.000 rs12531366 chr7:91683849 C/G cg17063962 chr7:91808500 NA 0.53 12.56 0.44 1.78e-32 Breast cancer; BRCA cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.52 -0.32 1.15e-16 Aortic root size; BRCA cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg13770153 chr20:60521292 NA -0.39 -9.17 -0.34 6.38e-19 Body mass index; BRCA cis rs9612 1.000 rs7246677 chr19:44248625 G/A cg08581076 chr19:44259116 C19orf61 0.53 9.2 0.34 5.06e-19 Exhaled nitric oxide output; BRCA cis rs2481665 0.546 rs927531 chr1:62634797 C/G cg18591186 chr1:62594603 INADL 0.38 8.1 0.31 2.78e-15 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.67 17.7 0.57 2.49e-57 Electrocardiographic conduction measures; BRCA cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg12311346 chr5:56204834 C5orf35 0.61 12.65 0.45 7.17e-33 Initial pursuit acceleration; BRCA cis rs681343 1.000 rs492602 chr19:49206417 A/G cg21064579 chr19:49206444 FUT2 0.37 9.25 0.34 3.4e-19 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11890956 chr21:40555474 PSMG1 0.82 20.73 0.63 2.25e-73 Cognitive function; BRCA cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg25767906 chr1:53392781 SCP2 0.34 7.88 0.3 1.42e-14 Monocyte count; BRCA cis rs2625529 0.730 rs6494990 chr15:72401074 T/A cg16672083 chr15:72433130 SENP8 0.72 17.15 0.56 1.55e-54 Red blood cell count; BRCA cis rs17270561 0.636 rs12194699 chr6:25729229 G/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg02659138 chr7:134003124 SLC35B4 0.41 12.03 0.43 3.53e-30 Mean platelet volume; BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs2204008 0.628 rs10876106 chr12:37990767 A/G cg26384229 chr12:38710491 ALG10B 0.67 15.37 0.52 1.35e-45 Bladder cancer; BRCA trans rs11039798 0.588 rs1847640 chr11:49004025 C/T cg15704280 chr7:45808275 SEPT13 0.6 10.02 0.37 4.9e-22 Axial length; BRCA trans rs6479891 1.000 rs4525102 chr10:65086273 C/T cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs7914558 0.966 rs7908280 chr10:104816947 C/G cg04362960 chr10:104952993 NT5C2 0.43 10.48 0.38 7.79e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9287719 0.649 rs10208103 chr2:10720867 G/A cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.52e-19 Prostate cancer; BRCA cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg01475377 chr6:109611718 NA -0.61 -16.79 -0.55 1.15e-52 Reticulocyte fraction of red cells; BRCA cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.13 0.37 1.75e-22 Bladder cancer; BRCA cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg12927641 chr6:109611667 NA -0.36 -8.92 -0.33 4.92e-18 Reticulocyte fraction of red cells; BRCA cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg25767906 chr1:53392781 SCP2 0.38 8.63 0.32 4.85e-17 Monocyte count; BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg22903471 chr2:27725779 GCKR -0.38 -9.44 -0.35 6.78e-20 Total body bone mineral density; BRCA cis rs870825 0.520 rs10022842 chr4:185649459 A/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs600806 0.778 rs891380 chr1:110003286 T/G cg20591472 chr1:110008990 SYPL2 0.31 7.9 0.3 1.21e-14 Intelligence (multi-trait analysis); BRCA cis rs4478858 0.684 rs11579845 chr1:31736248 A/G cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA trans rs6479891 1.000 rs9415708 chr10:65190042 G/C cg14819942 chr15:35414228 NA 0.35 8.58 0.32 6.95e-17 Arthritis (juvenile idiopathic); BRCA cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg14847009 chr1:175162515 KIAA0040 -0.24 -9.07 -0.34 1.41e-18 Alcohol dependence; BRCA cis rs9640161 0.789 rs1464753 chr7:150021350 G/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.57 -14.09 -0.49 1.94e-39 Blood protein levels;Circulating chemerin levels; BRCA cis rs61990749 0.597 rs10148373 chr14:78280199 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.66 9.48 0.35 4.79e-20 Fibroblast growth factor basic levels; BRCA cis rs13046373 0.535 rs1605428 chr21:32028976 T/C cg27071517 chr21:31768726 KRTAP13-1 0.3 7.86 0.3 1.61e-14 HDL cholesterol; BRCA cis rs2243480 1.000 rs464895 chr7:65527106 A/G cg18252515 chr7:66147081 NA -1.04 -13.91 -0.48 1.27e-38 Diabetic kidney disease; BRCA cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.21 0.41 9.04e-27 Bipolar disorder; BRCA cis rs4268898 0.722 rs11691212 chr2:24404733 A/G cg06627628 chr2:24431161 ITSN2 0.43 8.98 0.33 3.03e-18 Asthma; BRCA cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.47 -8.16 -0.31 1.76e-15 Schizophrenia; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.3 -0.44 2.46e-31 Alzheimer's disease; BRCA cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg13628971 chr7:2884303 GNA12 0.4 9.13 0.34 8.76e-19 Height; BRCA cis rs7618501 0.633 rs6771546 chr3:49968572 T/C cg24308560 chr3:49941425 MST1R -0.4 -8.47 -0.32 1.74e-16 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.936 rs7629987 chr3:161002023 A/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.03 -0.49 3.4e-39 Morning vs. evening chronotype; BRCA cis rs9858542 1.000 rs9823546 chr3:49705512 T/A cg03060546 chr3:49711283 APEH -0.57 -11.37 -0.41 2.01e-27 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.71 -12.2 -0.43 6.19e-31 Platelet count; BRCA cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.53 0.32 1.1e-16 Aortic root size; BRCA cis rs7552404 1.000 rs11161511 chr1:76210477 A/G cg22875332 chr1:76189707 ACADM -0.7 -14.87 -0.51 3.49e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.84 0.36 2.32e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg22337977 chr21:31811175 KRTAP15-1 0.35 8.57 0.32 7.68e-17 HDL cholesterol; BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.64 10.23 0.38 7.76e-23 Renal function-related traits (BUN); BRCA cis rs3768617 0.811 rs10911200 chr1:182998377 T/C ch.1.3577855R chr1:183094577 LAMC1 0.44 9.53 0.35 3.18e-20 Fuchs's corneal dystrophy; BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg22535103 chr8:58192502 C8orf71 0.53 9.28 0.34 2.69e-19 Developmental language disorder (linguistic errors); BRCA cis rs514406 0.893 rs476108 chr1:53317351 C/T cg01802117 chr1:53393560 SCP2 -0.36 -8.39 -0.31 3.16e-16 Monocyte count; BRCA cis rs507080 0.885 rs7926959 chr11:118559866 T/C cg08498647 chr11:118550644 TREH -0.38 -8.3 -0.31 6e-16 Serum metabolite levels; BRCA cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg11789530 chr4:8429930 ACOX3 -0.56 -13.41 -0.47 2.72e-36 Response to antineoplastic agents; BRCA cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg24324837 chr19:49891574 CCDC155 0.5 9.23 0.34 4.08e-19 Multiple sclerosis; BRCA cis rs4908760 0.860 rs11121202 chr1:8639357 T/C cg20416874 chr1:8611966 RERE -0.29 -8.22 -0.31 1.15e-15 Vitiligo; BRCA cis rs2749592 0.725 rs9417245 chr10:37826322 C/T cg25427524 chr10:38739819 LOC399744 0.52 9.79 0.36 3.47e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs36051895 0.560 rs1575281 chr9:5219131 T/C cg02405213 chr9:5042618 JAK2 -0.41 -7.94 -0.3 8.95e-15 Pediatric autoimmune diseases; BRCA cis rs7617773 0.817 rs4131361 chr3:48328812 T/C cg11946769 chr3:48343235 NME6 0.63 13.53 0.47 7.37e-37 Coronary artery disease; BRCA cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 15.63 0.53 7.54e-47 Smoking behavior; BRCA trans rs2727020 0.754 rs1851990 chr11:49413336 C/T cg03929089 chr4:120376271 NA -0.74 -15.94 -0.53 2.09e-48 Coronary artery disease; BRCA cis rs9649213 0.593 rs3779193 chr7:98028466 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.8 -0.33 1.25e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.898 rs72780188 chr2:24006065 G/A cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs1348850 0.526 rs10930797 chr2:178437553 C/G cg27490568 chr2:178487706 NA 0.52 8.4 0.32 2.9e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs12310956 0.532 rs10844715 chr12:33968444 A/G cg06521331 chr12:34319734 NA -0.53 -10.64 -0.39 1.79e-24 Morning vs. evening chronotype; BRCA cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg08109568 chr15:31115862 NA -0.44 -10.16 -0.37 1.44e-22 Huntington's disease progression; BRCA cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg26384229 chr12:38710491 ALG10B -0.58 -14.94 -0.51 1.72e-43 Morning vs. evening chronotype; BRCA cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg12219531 chr12:120966889 COQ5 0.55 11.49 0.41 6.52e-28 High light scatter reticulocyte count; BRCA cis rs4363385 0.747 rs1611753 chr1:152956381 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.26 -0.31 8.39e-16 Inflammatory skin disease; BRCA cis rs733592 0.507 rs56129148 chr12:48485530 T/C cg24011408 chr12:48396354 COL2A1 -0.43 -9.65 -0.36 1.13e-20 Plateletcrit; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg22963979 chr7:1858916 MAD1L1 -0.39 -8.11 -0.31 2.51e-15 Bipolar disorder and schizophrenia; BRCA cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.9 -0.3 1.26e-14 Colorectal cancer; BRCA trans rs11098499 0.908 rs2017057 chr4:120257711 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.93 0.43 9.32e-30 Corneal astigmatism; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg14004847 chr7:1930337 MAD1L1 0.42 8.12 0.31 2.44e-15 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1932281 chr6:8473765 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs6547741 0.935 rs6547738 chr2:27852637 A/G cg27432699 chr2:27873401 GPN1 0.43 8.98 0.33 3.01e-18 Oral cavity cancer; BRCA cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg21132104 chr15:45694354 SPATA5L1 0.73 16.29 0.54 3.75e-50 Homoarginine levels; BRCA cis rs7267979 1.000 rs12428 chr20:25433821 G/T cg08601574 chr20:25228251 PYGB -0.34 -8.09 -0.3 2.97e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1215050 0.791 rs4699318 chr4:98664370 T/G cg05340658 chr4:99064831 C4orf37 -0.44 -10.13 -0.37 1.76e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg05966235 chr16:28915196 ATP2A1 0.4 7.89 0.3 1.33e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2153535 0.623 rs2327055 chr6:8443145 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.0 0.34 2.57e-18 Motion sickness; BRCA cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg14963724 chr18:72166303 CNDP2 -0.34 -7.97 -0.3 7.22e-15 Refractive error; BRCA cis rs9467773 0.620 rs2504571 chr6:26643435 C/T cg11502198 chr6:26597334 ABT1 0.56 11.92 0.43 1e-29 Intelligence (multi-trait analysis); BRCA cis rs62458065 0.513 rs10265319 chr7:32571564 A/C cg20159608 chr7:32802032 NA -0.51 -9.77 -0.36 4.05e-21 Metabolite levels (HVA/MHPG ratio); BRCA cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg26647111 chr11:31128758 NA -0.44 -9.68 -0.36 9.03e-21 Red blood cell count; BRCA cis rs7520050 0.966 rs6662641 chr1:46571509 T/A cg24296786 chr1:45957014 TESK2 0.43 9.71 0.36 6.81e-21 Red blood cell count;Reticulocyte count; BRCA cis rs1953600 0.870 rs2245168 chr10:81921918 T/C cg04850286 chr10:81895943 PLAC9 -0.32 -9.17 -0.34 6.24e-19 Sarcoidosis; BRCA cis rs3125734 0.633 rs6479792 chr10:63983264 T/G cg19640130 chr10:64028056 RTKN2 -0.29 -8.41 -0.32 2.68e-16 Rheumatoid arthritis; BRCA cis rs765787 0.530 rs2413782 chr15:45538490 A/C cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs11229555 0.874 rs11605683 chr11:58350794 T/A cg15696309 chr11:58395628 NA -0.54 -11.75 -0.42 5.45e-29 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs938554 0.612 rs7669607 chr4:9997801 C/T cg00071950 chr4:10020882 SLC2A9 -0.41 -7.88 -0.3 1.46e-14 Blood metabolite levels; BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00166722 chr3:10149974 C3orf24 0.66 13.13 0.46 5.04e-35 Alzheimer's disease; BRCA cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg18876405 chr7:65276391 NA 0.62 15.48 0.52 4e-46 Aortic root size; BRCA cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg11247378 chr22:39784982 NA -0.63 -14.03 -0.49 3.47e-39 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg04553112 chr3:125709451 NA -0.56 -8.47 -0.32 1.68e-16 Blood pressure (smoking interaction); BRCA cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg08085267 chr17:45401833 C17orf57 -0.58 -11.98 -0.43 5.79e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs701145 0.585 rs1713804 chr3:153799122 A/G cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs6121246 0.909 rs6060812 chr20:30292803 C/T cg13852791 chr20:30311386 BCL2L1 0.86 16.75 0.55 1.82e-52 Mean corpuscular hemoglobin; BRCA cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg13319975 chr6:146136371 FBXO30 0.59 13.31 0.47 7.71e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs9297145 0.678 rs62473051 chr7:98781955 C/T cg05967295 chr7:98741636 SMURF1 0.96 17.83 0.58 5.33e-58 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs2012796 0.956 rs10450940 chr14:81825326 C/A cg02996355 chr14:81879375 NA 0.5 9.79 0.36 3.63e-21 Night sleep phenotypes; BRCA cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg01448562 chr3:133502909 NA -0.64 -14.94 -0.51 1.7e-43 Iron status biomarkers; BRCA cis rs7246657 0.943 rs2112923 chr19:37940327 C/T cg14683738 chr19:37701593 ZNF585B 0.44 7.9 0.3 1.22e-14 Coronary artery calcification; BRCA cis rs2742417 0.603 rs2742398 chr3:45759036 A/G cg04837898 chr3:45731254 SACM1L -0.42 -8.73 -0.33 2.23e-17 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs7592578 0.766 rs62182865 chr2:191434180 T/C cg11845111 chr2:191398756 TMEM194B -0.83 -14.85 -0.51 4.69e-43 Diastolic blood pressure; BRCA cis rs9650657 0.585 rs4841401 chr8:10489592 C/G cg27411982 chr8:10470053 RP1L1 -0.38 -8.22 -0.31 1.14e-15 Neuroticism; BRCA trans rs2562456 0.561 rs12610883 chr19:21750059 A/G cg25042112 chr7:64838748 ZNF92 -0.45 -8.23 -0.31 1.03e-15 Pain; BRCA cis rs910316 1.000 rs13099 chr14:75599155 G/A cg11812906 chr14:75593930 NEK9 -0.61 -13.8 -0.48 4.24e-38 Height; BRCA cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg11062466 chr8:58055876 NA 0.4 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg17845761 chr1:175162550 KIAA0040 -0.27 -10.05 -0.37 3.53e-22 Alcohol dependence; BRCA cis rs7512552 0.646 rs1694367 chr1:150329469 T/A cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.81e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs12477438 0.834 rs1563106 chr2:99701381 C/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.96 -0.43 6.96e-30 Chronic sinus infection; BRCA cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -15.66 -0.53 5.08e-47 Asthma; BRCA cis rs7727544 0.582 rs2278398 chr5:131530441 C/T cg14196790 chr5:131705035 SLC22A5 -0.37 -9.15 -0.34 7.33e-19 Blood metabolite levels; BRCA cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.45 0.32 1.96e-16 Bone mineral density; BRCA cis rs6459804 1.000 rs58278053 chr7:157512934 A/T cg05731713 chr7:157510257 PTPRN2 0.39 9.9 0.36 1.37e-21 Bipolar disorder and schizophrenia; BRCA cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg18198730 chr1:247681584 NA 0.49 11.23 0.41 8.03e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg04166393 chr7:2884313 GNA12 0.39 8.33 0.31 4.92e-16 Height; BRCA cis rs11690935 0.959 rs2292815 chr2:172586651 C/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -28.1 -0.74 9.91e-114 Schizophrenia; BRCA cis rs7385804 0.761 rs1617640 chr7:100317298 C/A cg16850897 chr7:100343110 ZAN 0.38 8.48 0.32 1.5e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.53 -0.61 5.49e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg00012203 chr2:219082015 ARPC2 0.58 12.37 0.44 1.21e-31 Colorectal cancer; BRCA cis rs9790314 0.746 rs898680 chr3:160772853 G/A cg03342759 chr3:160939853 NMD3 -0.51 -9.77 -0.36 4.24e-21 Morning vs. evening chronotype; BRCA trans rs1493916 0.744 rs7504560 chr18:31312148 A/G cg27147174 chr7:100797783 AP1S1 -0.41 -8.14 -0.31 2.1e-15 Life satisfaction; BRCA cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg03146154 chr1:46216737 IPP 0.46 10.12 0.37 1.99e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12586317 0.620 rs28404080 chr14:35539418 G/T cg16230307 chr14:35515116 FAM177A1 0.71 14.43 0.5 4.8e-41 Psoriasis; BRCA cis rs7552167 0.925 rs3932664 chr1:24511663 G/T cg01960748 chr1:24522592 NA -0.63 -10.88 -0.4 2.07e-25 Psoriasis vulgaris; BRCA cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -9.31 -0.35 2.06e-19 Monocyte percentage of white cells; BRCA cis rs6429082 0.715 rs2153204 chr1:235580382 A/G cg26050004 chr1:235667680 B3GALNT2 -0.55 -13.8 -0.48 4.23e-38 Adiposity; BRCA cis rs2997447 0.655 rs2275950 chr1:26385003 T/C cg19633962 chr1:26362018 EXTL1 -0.55 -9.92 -0.37 1.16e-21 QRS complex (12-leadsum); BRCA cis rs8114671 0.562 rs6120739 chr20:33405227 A/G cg24642439 chr20:33292090 TP53INP2 0.41 8.65 0.32 4e-17 Height; BRCA cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg26031613 chr14:104095156 KLC1 0.72 15.39 0.52 1.13e-45 Body mass index; BRCA cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.23 0.41 7.85e-27 Schizophrenia; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg21782813 chr7:2030301 MAD1L1 -0.4 -10.59 -0.39 2.96e-24 Bipolar disorder and schizophrenia; BRCA cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg04317338 chr11:64019027 PLCB3 0.54 9.57 0.35 2.32e-20 Mean platelet volume; BRCA cis rs7264396 0.616 rs6060744 chr20:34581555 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -11.03 -0.4 5.34e-26 Total cholesterol levels; BRCA cis rs17685 0.672 rs1639623 chr7:75707951 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.86 -0.33 8.2e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs344364 0.511 rs2906912 chr16:1953151 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.53 -9.49 -0.35 4.41e-20 Glomerular filtration rate in chronic kidney disease; BRCA cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.85 -0.39 2.62e-25 Personality dimensions; BRCA cis rs8062405 0.755 rs2077031 chr16:28603168 T/A cg16576597 chr16:28551801 NUPR1 0.34 9.13 0.34 8.58e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11599315 0.507 rs12218307 chr10:1341914 G/A cg27336068 chr10:1336103 ADARB2 -0.29 -7.99 -0.3 6.44e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs208520 0.754 rs851594 chr6:66876695 A/G cg07460842 chr6:66804631 NA -0.98 -18.46 -0.59 2.69e-61 Exhaled nitric oxide output; BRCA cis rs3771570 1.000 rs56052835 chr2:242243251 T/G cg21155796 chr2:242212141 HDLBP 0.61 9.63 0.36 1.42e-20 Prostate cancer; BRCA cis rs7100689 0.646 rs9420370 chr10:82073248 C/T cg00277334 chr10:82204260 NA -0.42 -8.34 -0.31 4.51e-16 Post bronchodilator FEV1; BRCA cis rs3749237 1.000 rs4768 chr3:49758764 A/G cg03060546 chr3:49711283 APEH 0.49 10.58 0.39 3.14e-24 Resting heart rate; BRCA cis rs6964587 0.743 rs33993294 chr7:91998655 A/C cg01689657 chr7:91764605 CYP51A1 0.23 8.13 0.31 2.16e-15 Breast cancer; BRCA cis rs17228212 1.000 rs11630297 chr15:67443964 C/G cg26876701 chr15:67458665 SMAD3 -0.47 -9.14 -0.34 8.13e-19 Coronary heart disease; BRCA cis rs6964587 0.967 rs12538325 chr7:91757479 A/G cg01689657 chr7:91764605 CYP51A1 0.24 8.58 0.32 7.26e-17 Breast cancer; BRCA cis rs1371614 0.635 rs4316900 chr2:27140342 C/T cg12368169 chr2:27073192 DPYSL5 -0.29 -8.65 -0.32 4.02e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10493773 0.894 rs12067749 chr1:86197922 T/C cg17807903 chr1:86174739 ZNHIT6 -0.49 -10.85 -0.39 2.78e-25 Urate levels in overweight individuals; BRCA cis rs17253792 0.822 rs9972178 chr14:56073480 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.91 0.3 1.15e-14 Putamen volume; BRCA cis rs11231017 0.507 rs11231027 chr11:62080042 C/T cg23876832 chr11:62092739 NA 0.32 8.05 0.3 4e-15 HIV-1 viral setpoint; BRCA cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.21 -0.31 1.26e-15 Breast cancer; BRCA cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg11584989 chr19:19387371 SF4 -0.63 -13.5 -0.47 1e-36 Bipolar disorder; BRCA cis rs34779708 0.966 rs1478463 chr10:35473035 G/A cg03585969 chr10:35415529 CREM 0.49 10.36 0.38 2.43e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2274471 0.582 rs57839907 chr9:5082671 T/A cg03390472 chr9:5043263 JAK2 -0.49 -8.94 -0.33 4.31e-18 Crohn's disease; BRCA cis rs9486719 1.000 rs11752584 chr6:96884952 C/A cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.7200000000000002e-34 Migraine;Coronary artery disease; BRCA cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.08 -0.3 3.23e-15 Cognitive function; BRCA cis rs3768617 0.706 rs9943067 chr1:182975102 C/T ch.1.3577855R chr1:183094577 LAMC1 0.5 11.6 0.42 2.24e-28 Fuchs's corneal dystrophy; BRCA cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg18404041 chr3:52824283 ITIH1 0.36 11.21 0.41 9.35e-27 Electroencephalogram traits; BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg22920501 chr2:26401640 FAM59B 0.76 10.85 0.39 2.68e-25 Gut microbiome composition (summer); BRCA cis rs908922 0.676 rs7529441 chr1:152531629 A/G cg20991723 chr1:152506922 NA -0.41 -9.25 -0.34 3.29e-19 Hair morphology; BRCA cis rs17401966 0.838 rs1556917 chr1:10400990 G/T cg03954927 chr1:10346856 KIF1B 0.44 13.59 0.47 3.94e-37 Hepatocellular carcinoma; BRCA trans rs17685 0.671 rs60303271 chr7:75760008 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs1005277 0.505 rs719569 chr10:38154415 T/G cg17830980 chr10:43048298 ZNF37B 0.42 9.91 0.36 1.23e-21 Extrinsic epigenetic age acceleration; BRCA trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg23505145 chr19:12996616 KLF1 0.54 12.28 0.44 2.74e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs3806843 0.868 rs2531345 chr5:140126781 T/G cg16179182 chr5:140090404 VTRNA1-1 0.41 9.26 0.34 3.03e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs1538970 0.774 rs67683090 chr1:45977803 T/G cg05343316 chr1:45956843 TESK2 0.7 14.5 0.5 2.1e-41 Platelet count; BRCA cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg26597838 chr10:835615 NA 1.0 15.69 0.53 3.62e-47 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.580 rs1119691 chr6:8460452 C/T cg21535247 chr6:8435926 SLC35B3 0.4 8.99 0.33 2.86e-18 Motion sickness; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg18402987 chr7:1209562 NA 0.86 14.02 0.48 3.98e-39 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs546131 0.928 rs558967 chr11:34827168 T/A cg06937548 chr11:34938143 PDHX;APIP 0.45 8.49 0.32 1.49e-16 Lung disease severity in cystic fibrosis; BRCA cis rs6028335 0.610 rs73110616 chr20:37552943 C/T cg16355469 chr20:37678765 NA 0.45 8.12 0.31 2.46e-15 Alcohol and nicotine co-dependence; BRCA cis rs2249625 0.545 rs2463746 chr6:72876954 C/G cg18830697 chr6:72922368 RIMS1 -0.64 -14.66 -0.5 3.57e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs7267979 1.000 rs2482941 chr20:25361216 T/C cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.5 0.57 2.57e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 14.94 0.51 1.6700000000000001e-43 Colorectal cancer; BRCA cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg21475434 chr5:93447410 FAM172A 0.68 8.6 0.32 6.23e-17 Diabetic retinopathy; BRCA cis rs9814567 1.000 rs10804632 chr3:134294501 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.33 -0.61 6.56e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs34330 0.562 rs11055024 chr12:12858969 A/G cg04607235 chr12:12878440 APOLD1 -0.7 -10.83 -0.39 3.27e-25 Systemic lupus erythematosus; BRCA cis rs2625529 0.701 rs2306490 chr15:72227837 A/G cg16672083 chr15:72433130 SENP8 -0.84 -17.34 -0.57 1.67e-55 Red blood cell count; BRCA cis rs67311347 1.000 rs13073003 chr3:40504326 C/T cg01475735 chr3:40494733 NA 0.47 9.88 0.36 1.65e-21 Renal cell carcinoma; BRCA cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg00321850 chr1:175162397 KIAA0040 0.43 12.25 0.44 3.99e-31 Alcohol dependence; BRCA trans rs11098499 0.866 rs6824111 chr4:120285968 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg18279126 chr7:2041391 MAD1L1 0.37 8.21 0.31 1.22e-15 Bipolar disorder and schizophrenia; BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg12648201 chr2:27665141 KRTCAP3 -0.32 -7.95 -0.3 8.66e-15 Total body bone mineral density; BRCA cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg24110177 chr3:50126178 RBM5 -0.52 -14.65 -0.5 4.16e-42 Body mass index; BRCA trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg15704280 chr7:45808275 SEPT13 -0.74 -15.15 -0.51 1.55e-44 Coronary artery disease; BRCA cis rs9837602 1.000 rs6799379 chr3:99762840 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.54 0.38 4.86e-24 Breast cancer; BRCA cis rs7246967 0.673 rs55684269 chr19:22924547 C/T cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg27029518 chr18:72166324 CNDP2 -0.31 -8.68 -0.32 3.35e-17 Refractive error; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.69 0.33 3.07e-17 Platelet count; BRCA cis rs3820928 1.000 rs11686072 chr2:227777493 A/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.49 -0.32 1.47e-16 Pulmonary function; BRCA cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg08847533 chr14:75593920 NEK9 -0.92 -24.52 -0.7 4.24e-94 Height; BRCA cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 22.89 0.67 3.9e-85 Chronic sinus infection; BRCA cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.64 9.48 0.35 4.92e-20 Initial pursuit acceleration; BRCA cis rs1863824 0.625 rs2018507 chr10:88163251 A/G cg07322936 chr10:88137208 NA 0.45 9.24 0.34 3.76e-19 Schizophrenia; BRCA cis rs929354 1.000 rs1182377 chr7:157048403 T/C cg17757837 chr7:157058334 UBE3C -0.72 -17.78 -0.58 9.39e-58 Body mass index; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg00106254 chr7:1943704 MAD1L1 -0.34 -8.4 -0.32 2.95e-16 Bipolar disorder and schizophrenia; BRCA cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg25237894 chr2:233734115 C2orf82 -0.39 -11.39 -0.41 1.64e-27 Coronary artery disease; BRCA cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg03709012 chr19:19516395 GATAD2A 0.73 16.31 0.54 2.86e-50 Tonsillectomy; BRCA cis rs1788820 0.917 rs1788826 chr18:21154024 G/A cg14672496 chr18:21087552 C18orf8 0.34 8.11 0.31 2.6e-15 Body mass index; BRCA cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.88 0.48 1.73e-38 Coronary artery disease; BRCA cis rs4925386 0.840 rs6142738 chr20:60919960 C/T cg06026331 chr20:60912101 LAMA5 -0.61 -12.26 -0.44 3.65e-31 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg26031613 chr14:104095156 KLC1 -0.44 -8.72 -0.33 2.36e-17 Schizophrenia; BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg05457628 chr5:178986728 RUFY1 0.49 11.79 0.42 3.55e-29 Lung cancer; BRCA cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.18 0.31 1.53e-15 Uric acid levels; BRCA cis rs2404602 0.647 rs2404600 chr15:77173557 C/T cg23625390 chr15:77176239 SCAPER -0.56 -12.99 -0.46 2.04e-34 Blood metabolite levels; BRCA cis rs977987 0.806 rs4888411 chr16:75443183 T/A cg03315344 chr16:75512273 CHST6 0.53 12.48 0.44 3.9e-32 Dupuytren's disease; BRCA cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2070488 0.965 rs2154778 chr3:38553639 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.7 -19.13 -0.6 7.98e-65 Electrocardiographic conduction measures; BRCA cis rs7520050 0.807 rs6656279 chr1:46124088 C/G cg24296786 chr1:45957014 TESK2 -0.46 -10.54 -0.38 4.86e-24 Red blood cell count;Reticulocyte count; BRCA cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg06145435 chr7:1022769 CYP2W1 0.48 8.88 0.33 6.82e-18 Bronchopulmonary dysplasia; BRCA cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg03517284 chr6:25882590 NA 0.48 9.95 0.37 8.66e-22 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.04e-15 Alzheimer's disease (late onset); BRCA cis rs12410462 0.792 rs994666 chr1:227651454 C/T cg23173402 chr1:227635558 NA -0.46 -8.31 -0.31 5.64e-16 Major depressive disorder; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.9 -0.45 5.23e-34 Lymphocyte counts; BRCA cis rs4862307 0.836 rs11132220 chr4:184997247 A/T cg06737308 chr4:185021514 ENPP6 -0.4 -9.22 -0.34 4.12e-19 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs427394 0.802 rs274692 chr5:6734625 C/T cg10857441 chr5:6722123 POLS -0.33 -10.91 -0.4 1.54e-25 Menopause (age at onset); BRCA cis rs1865760 1.000 rs2071301 chr6:25914263 G/T cg17691542 chr6:26056736 HIST1H1C 0.5 10.33 0.38 3.05e-23 Height; BRCA cis rs11098499 0.954 rs10034623 chr4:120397829 G/A cg09307838 chr4:120376055 NA 0.77 17.12 0.56 2.42e-54 Corneal astigmatism; BRCA cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg11584989 chr19:19387371 SF4 -0.6 -13.51 -0.47 9.58e-37 Bipolar disorder; BRCA cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.89 -0.3 1.36e-14 Aortic root size; BRCA cis rs1448094 0.511 rs59668915 chr12:86197170 C/T cg19622623 chr12:86230825 RASSF9 -0.3 -8.16 -0.31 1.84e-15 Major depressive disorder; BRCA cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg18904891 chr8:8559673 CLDN23 0.65 12.9 0.45 5.46e-34 Obesity-related traits; BRCA cis rs4481887 0.927 rs4517383 chr1:248426484 C/T cg00666640 chr1:248458726 OR2T12 0.3 8.55 0.32 9.3e-17 Common traits (Other); BRCA cis rs9733 0.635 rs486836 chr1:150875967 A/T cg13175981 chr1:150552382 MCL1 0.41 9.15 0.34 7.57e-19 Tonsillectomy; BRCA cis rs4764124 0.646 rs10744078 chr12:14978535 T/G cg19759883 chr12:14956454 WBP11;C12orf60 -0.52 -11.69 -0.42 9.73e-29 Pubertal anthropometrics; BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg01939980 chr4:1354348 KIAA1530 0.37 9.59 0.35 1.93e-20 Longevity; BRCA cis rs9287719 0.967 rs10203785 chr2:10752508 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.96 -0.3 7.79e-15 Prostate cancer; BRCA cis rs6938 0.534 rs12904897 chr15:75217686 A/G cg13906792 chr15:75199810 C15orf17 -0.4 -9.5 -0.35 4.16e-20 Breast cancer; BRCA cis rs9463078 0.774 rs9381383 chr6:45271893 G/A cg25276700 chr6:44698697 NA -0.36 -8.14 -0.31 2.01e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2777491 0.957 rs919961 chr15:41651721 A/G cg18705301 chr15:41695430 NDUFAF1 -0.62 -14.36 -0.49 9.47e-41 Ulcerative colitis; BRCA trans rs7939886 0.920 rs79521305 chr11:55811332 G/A cg15704280 chr7:45808275 SEPT13 0.62 7.95 0.3 8.52e-15 Myopia (pathological); BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg23358479 chr7:1110784 C7orf50 -0.47 -7.94 -0.3 9.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12579753 0.879 rs11115009 chr12:82165409 G/T cg07988820 chr12:82153109 PPFIA2 0.65 11.07 0.4 3.46e-26 Resting heart rate; BRCA cis rs2859741 1.000 rs1773575 chr1:37505129 T/C cg09363841 chr1:37513479 NA -0.66 -16.27 -0.54 4.95e-50 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA trans rs9329221 0.710 rs11785061 chr8:10259528 G/C cg15556689 chr8:8085844 FLJ10661 0.34 8.07 0.3 3.55e-15 Neuroticism; BRCA cis rs9399137 0.507 rs12663447 chr6:135317026 A/C cg24558204 chr6:135376177 HBS1L 0.6 16.25 0.54 5.98e-50 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs300703 0.542 rs300697 chr2:184496 C/T cg21211680 chr2:198530 NA -0.39 -8.15 -0.31 1.98e-15 Blood protein levels; BRCA cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg25554036 chr4:6271136 WFS1 0.41 9.7 0.36 7.82e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.95 -0.46 3.08e-34 Lymphocyte counts; BRCA cis rs8114671 0.935 rs945960 chr20:33762854 A/G cg07148914 chr20:33460835 GGT7 0.38 8.03 0.3 4.77e-15 Height; BRCA cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.52 -0.32 1.14e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg11625262 chr3:156393772 TIPARP;LOC100287227 0.35 8.36 0.31 4e-16 Mosquito bite size; BRCA cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg26384229 chr12:38710491 ALG10B -0.58 -13.6 -0.47 3.66e-37 Bladder cancer; BRCA cis rs1707322 1.000 rs4641257 chr1:46353589 G/A cg03146154 chr1:46216737 IPP 0.45 9.95 0.37 8.9e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg08917208 chr2:24149416 ATAD2B 0.58 9.11 0.34 1.09e-18 Lymphocyte counts; BRCA cis rs7737355 1.000 rs6596010 chr5:130625411 G/A cg06307176 chr5:131281290 NA 0.46 9.04 0.34 1.83e-18 Life satisfaction; BRCA cis rs7412746 0.658 rs12068264 chr1:150727329 C/T cg15448220 chr1:150897856 SETDB1 0.37 8.3 0.31 6.19e-16 Melanoma; BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg03709012 chr19:19516395 GATAD2A 0.82 19.22 0.61 2.52e-65 Tonsillectomy; BRCA cis rs7777754 0.512 rs3757472 chr7:50537983 A/C cg18232548 chr7:50535776 DDC -0.54 -13.36 -0.47 4.59e-36 Response to zileuton treatment in asthma (FEV1 change interaction); BRCA cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs17641971 0.684 rs4873100 chr8:50025772 G/A cg00325661 chr8:49890786 NA 0.36 10.09 0.37 2.54e-22 Blood metabolite levels; BRCA cis rs4660306 0.961 rs1337902 chr1:45952066 G/A cg24296786 chr1:45957014 TESK2 0.42 8.39 0.32 3.08e-16 Homocysteine levels; BRCA cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg22800045 chr5:56110881 MAP3K1 0.66 12.19 0.43 7.23e-31 Initial pursuit acceleration; BRCA cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg08213375 chr14:104286397 PPP1R13B 0.65 18.58 0.59 5.9e-62 Schizophrenia; BRCA cis rs7927771 0.864 rs7937331 chr11:47430458 T/C cg20307385 chr11:47447363 PSMC3 0.4 9.08 0.34 1.39e-18 Subjective well-being; BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg26314531 chr2:26401878 FAM59B -0.63 -10.65 -0.39 1.69e-24 Gut microbiome composition (summer); BRCA cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.72 0.6 1.16e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs12431939 0.947 rs55974960 chr14:51633742 T/C cg23942311 chr14:51606299 NA -0.45 -8.5 -0.32 1.33e-16 Cancer; BRCA cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg12564285 chr5:131593104 PDLIM4 0.35 7.89 0.3 1.35e-14 Breast cancer; BRCA cis rs17253792 0.822 rs76557162 chr14:56064701 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.98 0.3 7e-15 Putamen volume; BRCA cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.19 -0.34 5.31e-19 Menopause (age at onset); BRCA cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg21724239 chr8:58056113 NA 0.58 9.44 0.35 7.02e-20 Developmental language disorder (linguistic errors); BRCA cis rs11608355 0.545 rs11066737 chr12:109904792 A/G cg05360138 chr12:110035743 NA -0.72 -13.07 -0.46 9.05e-35 Neuroticism; BRCA cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.2 -0.31 1.31e-15 Colorectal cancer; BRCA cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.95e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -14.87 -0.51 3.48e-43 Cognitive function; BRCA trans rs3942852 0.726 rs1503171 chr11:48175152 T/C cg03929089 chr4:120376271 NA -0.5 -9.33 -0.35 1.66e-19 Acute lymphoblastic leukemia (childhood); BRCA trans rs9858542 0.953 rs6766581 chr3:49539401 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.66 -0.36 1.04e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11890956 chr21:40555474 PSMG1 1.06 31.88 0.78 3.44e-134 Cognitive function; BRCA cis rs7617773 0.817 rs6787500 chr3:48299439 T/C cg11946769 chr3:48343235 NME6 0.51 11.65 0.42 1.41e-28 Coronary artery disease; BRCA cis rs10870270 0.956 rs10870281 chr10:133762642 G/A cg17892150 chr10:133769511 PPP2R2D -0.72 -15.51 -0.52 2.66e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs911119 1.000 rs34897231 chr20:23620268 A/G cg16589663 chr20:23618590 CST3 0.47 8.81 0.33 1.2e-17 Chronic kidney disease; BRCA cis rs514406 0.679 rs541852 chr1:53256834 A/G cg16325326 chr1:53192061 ZYG11B -0.56 -11.45 -0.41 1.01e-27 Monocyte count; BRCA cis rs13046373 0.535 rs9636840 chr21:32029979 A/G cg16812893 chr21:31813075 KRTAP15-1 -0.35 -8.73 -0.33 2.22e-17 HDL cholesterol; BRCA cis rs3617 0.625 rs2240917 chr3:52851137 T/C cg11645453 chr3:52864694 ITIH4 0.37 9.66 0.36 1.07e-20 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg21573476 chr21:45109991 RRP1B -0.35 -9.21 -0.34 4.5e-19 Mean corpuscular volume; BRCA cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg08000102 chr2:233561755 GIGYF2 0.63 13.98 0.48 6.09e-39 Coronary artery disease; BRCA cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg24562669 chr7:97807699 LMTK2 0.46 12.35 0.44 1.36e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs7726839 0.561 rs72703058 chr5:584519 G/A cg09021430 chr5:549028 NA -0.64 -15.31 -0.52 2.54e-45 Obesity-related traits; BRCA trans rs262150 0.851 rs2730249 chr7:158767628 A/G cg21167628 chr1:45308625 PTCH2 0.31 8.19 0.31 1.41e-15 Facial morphology (factor 20); BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.5 10.25 0.38 6.13e-23 Lymphocyte counts; BRCA cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg04034577 chr2:241836375 C2orf54 0.53 12.33 0.44 1.69e-31 Urinary metabolites; BRCA cis rs7615952 0.673 rs35955861 chr3:125626201 T/C cg05084668 chr3:125655381 ALG1L -0.81 -11.22 -0.41 8.48e-27 Blood pressure (smoking interaction); BRCA cis rs36051895 0.623 rs62541541 chr9:5040817 G/C cg02405213 chr9:5042618 JAK2 -0.51 -9.18 -0.34 5.92e-19 Pediatric autoimmune diseases; BRCA trans rs2736345 0.788 rs2618476 chr8:11352541 A/G cg15556689 chr8:8085844 FLJ10661 0.34 8.06 0.3 3.66e-15 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs6973256 0.897 rs7780456 chr7:133328782 C/T cg07491979 chr7:133331646 EXOC4 -0.38 -8.78 -0.33 1.54e-17 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.966 rs60369822 chr3:47479735 A/C cg16586182 chr3:47516702 SCAP 0.66 15.18 0.51 1.11e-44 Colorectal cancer; BRCA trans rs62103177 0.810 rs62103175 chr18:77622467 C/T cg05926928 chr17:57297772 GDPD1 1.17 16.02 0.54 7.9e-49 Opioid sensitivity; BRCA cis rs6815814 0.950 rs11722788 chr4:38810738 C/G cg02016764 chr4:38805732 TLR1 -0.6 -9.46 -0.35 6.03e-20 Breast cancer; BRCA cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg14343924 chr8:8086146 FLJ10661 0.41 8.55 0.32 9.27e-17 Mood instability; BRCA cis rs2505998 0.868 rs2505991 chr10:43566360 A/G cg15436174 chr10:43711423 RASGEF1A -0.42 -7.86 -0.3 1.58e-14 Hirschsprung disease; BRCA cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg02544614 chr20:61657117 NA 0.3 8.38 0.31 3.49e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg17063962 chr7:91808500 NA 0.57 13.09 0.46 7.76e-35 Breast cancer; BRCA cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.41 9.06 0.34 1.63e-18 Bone mineral density (spine);Bone mineral density; BRCA cis rs7103648 0.897 rs11606287 chr11:47407439 C/A cg20307385 chr11:47447363 PSMC3 0.82 20.88 0.64 3.43e-74 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg05623727 chr3:50126028 RBM5 0.49 11.63 0.42 1.64e-28 Intelligence (multi-trait analysis); BRCA cis rs4268898 0.896 rs2702042 chr2:24546542 C/T cg06627628 chr2:24431161 ITSN2 -0.51 -10.31 -0.38 3.53e-23 Asthma; BRCA cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg12310025 chr6:25882481 NA -0.54 -13.04 -0.46 1.21e-34 Blood metabolite levels; BRCA cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg11822812 chr5:140052017 DND1 0.31 8.41 0.32 2.68e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs3849570 1.000 rs9826270 chr3:81841869 C/T cg07356753 chr3:81810745 GBE1 -0.47 -11.26 -0.41 5.86e-27 Waist circumference;Body mass index; BRCA cis rs4919694 1.000 rs4919694 chr10:104698978 T/C cg04362960 chr10:104952993 NT5C2 0.92 14.83 0.51 5.5e-43 Arsenic metabolism; BRCA trans rs12310956 0.532 rs7967627 chr12:33974669 G/T cg26384229 chr12:38710491 ALG10B 0.52 11.22 0.41 8.47e-27 Morning vs. evening chronotype; BRCA cis rs3806843 0.966 rs2563260 chr5:140137867 C/A cg16179182 chr5:140090404 VTRNA1-1 0.43 10.29 0.38 4.32e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs4285028 0.948 rs10934565 chr3:121664661 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.84 -0.39 2.9e-25 Multiple sclerosis; BRCA cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.61 0.36 1.7e-20 Eosinophil percentage of white cells; BRCA cis rs9486715 0.790 rs2971602 chr6:97022468 C/T cg06623918 chr6:96969491 KIAA0776 -0.93 -27.35 -0.73 1.21e-109 Headache; BRCA trans rs61931739 0.500 rs10772154 chr12:34373271 A/C cg13010199 chr12:38710504 ALG10B 0.42 9.04 0.34 1.83e-18 Morning vs. evening chronotype; BRCA cis rs2011503 1.000 rs2965201 chr19:19478051 C/T cg15839431 chr19:19639596 YJEFN3 0.41 8.9 0.33 5.7e-18 Bipolar disorder; BRCA cis rs2404602 0.647 rs11072618 chr15:77019342 A/G cg23625390 chr15:77176239 SCAPER -0.55 -12.91 -0.45 4.98e-34 Blood metabolite levels; BRCA cis rs11098499 0.913 rs10010696 chr4:120164303 T/C cg09307838 chr4:120376055 NA 0.61 12.32 0.44 1.99e-31 Corneal astigmatism; BRCA cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg00101154 chr16:420108 MRPL28 -0.4 -8.59 -0.32 6.63e-17 Bone mineral density (spine);Bone mineral density; BRCA cis rs9790314 0.631 rs2061804 chr3:161102474 C/A cg03342759 chr3:160939853 NMD3 -0.61 -13.64 -0.47 2.37e-37 Morning vs. evening chronotype; BRCA trans rs7178375 1.000 rs7178375 chr15:31215935 C/T cg04373760 chr16:53404718 NA 0.5 9.22 0.34 4.37e-19 Hypertriglyceridemia; BRCA cis rs11249608 0.548 rs34881171 chr5:178451932 C/T cg21905437 chr5:178450457 ZNF879 0.55 11.34 0.41 2.83e-27 Pubertal anthropometrics; BRCA cis rs7100689 0.622 rs7090351 chr10:82142047 T/G cg01528321 chr10:82214614 TSPAN14 0.83 18.6 0.59 5.14e-62 Post bronchodilator FEV1; BRCA cis rs7666738 0.830 rs4443295 chr4:99044935 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 9.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10463316 0.894 rs7729216 chr5:150762277 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs4718428 0.672 rs4718412 chr7:66286867 C/T cg12165864 chr7:66369176 NA 0.43 9.49 0.35 4.53e-20 Corneal structure; BRCA cis rs3820928 0.845 rs4234065 chr2:227882006 C/T cg11843606 chr2:227700838 RHBDD1 -0.36 -7.89 -0.3 1.28e-14 Pulmonary function; BRCA cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.03 -0.3 4.72e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg04944784 chr2:26401820 FAM59B -0.74 -11.64 -0.42 1.58e-28 Gut microbiome composition (summer); BRCA cis rs73001065 0.792 rs17216525 chr19:19662220 C/T cg03709012 chr19:19516395 GATAD2A 0.86 9.37 0.35 1.21e-19 LDL cholesterol; BRCA cis rs6700896 0.931 rs4420065 chr1:66161461 T/C cg04111102 chr1:66153794 NA -0.35 -8.5 -0.32 1.35e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg06636001 chr8:8085503 FLJ10661 -0.5 -10.39 -0.38 1.83e-23 Monocyte count; BRCA cis rs6142102 0.625 rs6141431 chr20:32540314 G/A cg24642439 chr20:33292090 TP53INP2 0.39 7.83 0.3 2.04e-14 Skin pigmentation; BRCA cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg22974920 chr21:40686053 BRWD1 -0.39 -8.56 -0.32 8.48e-17 Cognitive function; BRCA cis rs6893300 0.785 rs7705530 chr5:179190994 C/T cg14593053 chr5:179126677 CANX -0.36 -8.09 -0.3 2.9e-15 Resting heart rate; BRCA cis rs524281 0.861 rs10791854 chr11:65963543 A/T cg16950941 chr11:66035639 RAB1B -0.38 -8.03 -0.3 4.85e-15 Electroencephalogram traits; BRCA cis rs2066819 0.786 rs111580405 chr12:56739557 A/G cg26714650 chr12:56694279 CS -1.2 -15.49 -0.52 3.36e-46 Psoriasis vulgaris; BRCA cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg06671706 chr8:8559999 CLDN23 0.44 8.33 0.31 4.87e-16 Obesity-related traits; BRCA cis rs2046867 0.818 rs1502758 chr3:72865126 A/G cg25664220 chr3:72788482 NA -0.55 -11.7 -0.42 8.66e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg04450456 chr4:17643702 FAM184B 0.33 9.51 0.35 3.74e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.517 rs1843737 chr12:34015305 A/G cg26384229 chr12:38710491 ALG10B 0.47 10.42 0.38 1.35e-23 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.61 0.36 1.65e-20 Motion sickness; BRCA cis rs12477438 0.501 rs11683107 chr2:99759235 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.88 0.64 3.29e-74 Chronic sinus infection; BRCA cis rs1003719 0.788 rs2006941 chr21:38467616 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs12479064 0.724 rs3087403 chr2:100058870 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -9.27 -0.34 2.71e-19 Chronic sinus infection; BRCA cis rs9287719 0.614 rs12329184 chr2:10722764 T/C cg00105475 chr2:10696890 NA 0.41 9.17 0.34 6.17e-19 Prostate cancer; BRCA cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg23711669 chr6:146136114 FBXO30 0.71 17.01 0.56 8.7e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.67 10.46 0.38 9.82e-24 Schizophrenia; BRCA cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -12.68 -0.45 5.18e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1829883 0.748 rs1916598 chr5:98743288 G/A cg08333243 chr5:99726346 NA 0.34 8.41 0.32 2.65e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs6460942 1.000 rs6460938 chr7:12406808 T/G cg06484146 chr7:12443880 VWDE -0.71 -9.98 -0.37 6.65e-22 Coronary artery disease; BRCA cis rs926392 0.640 rs7268716 chr20:37693214 C/T cg16355469 chr20:37678765 NA 0.53 11.62 0.42 1.98e-28 Dialysis-related mortality; BRCA cis rs2718058 0.519 rs2598072 chr7:37875319 A/C cg15028436 chr7:37888078 TXNDC3 0.34 7.87 0.3 1.47e-14 Alzheimer's disease (late onset); BRCA cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.17e-27 High light scatter reticulocyte count; BRCA trans rs17685 0.712 rs6976236 chr7:75741087 G/T cg19862616 chr7:65841803 NCRNA00174 0.84 27.77 0.74 6.62e-112 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs61931739 0.534 rs11053073 chr12:34202412 C/T cg26384229 chr12:38710491 ALG10B 0.67 14.29 0.49 2.1e-40 Morning vs. evening chronotype; BRCA cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.39 0.35 1e-19 Tonsillectomy; BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.32 0.61 7.31e-66 Alzheimer's disease; BRCA cis rs55883249 0.958 rs17362734 chr2:9730208 A/G cg23886495 chr2:9695866 ADAM17 0.55 7.93 0.3 9.58e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg11707556 chr5:10655725 ANKRD33B 0.42 9.39 0.35 1.06e-19 Coronary artery disease; BRCA cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg23711669 chr6:146136114 FBXO30 0.72 16.38 0.54 1.28e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs12579753 0.879 rs7971664 chr12:82264101 T/C cg07988820 chr12:82153109 PPFIA2 -0.49 -8.06 -0.3 3.76e-15 Resting heart rate; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg05863683 chr7:1912471 MAD1L1 -0.41 -8.7 -0.33 2.75e-17 Bipolar disorder and schizophrenia; BRCA cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg11663144 chr21:46675770 NA 0.59 13.94 0.48 9.39e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg20090143 chr19:45452003 APOC2 0.27 8.1 0.31 2.69e-15 Blood protein levels; BRCA cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg12573674 chr2:1569213 NA -0.5 -9.59 -0.35 2.01e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7903847 0.619 rs9888116 chr10:99159482 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.43 -0.32 2.23e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg21573476 chr21:45109991 RRP1B -0.37 -9.64 -0.36 1.32e-20 Mean corpuscular volume; BRCA cis rs1030877 0.515 rs2576741 chr2:105897964 T/C cg02079111 chr2:105885981 TGFBRAP1 0.67 12.76 0.45 2.24e-33 Obesity-related traits; BRCA cis rs61612642 0.537 rs73434275 chr6:42156239 G/A cg10382835 chr6:42185730 MRPS10 0.53 8.04 0.3 4.34e-15 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg05084668 chr3:125655381 ALG1L -0.47 -8.09 -0.3 2.91e-15 Blood pressure (smoking interaction); BRCA trans rs4714291 0.802 rs2984430 chr6:39983741 A/G cg02267698 chr19:7991119 CTXN1 -0.45 -9.32 -0.35 1.92e-19 Strep throat; BRCA cis rs6831352 0.918 rs29001231 chr4:100046680 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs8141529 0.748 rs5997412 chr22:29276747 G/A cg02153584 chr22:29168773 CCDC117 0.58 12.3 0.44 2.24e-31 Lymphocyte counts; BRCA cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg17143192 chr8:8559678 CLDN23 -0.51 -9.81 -0.36 2.92e-21 Obesity-related traits; BRCA cis rs7927771 0.965 rs4752845 chr11:47539697 T/C cg18512352 chr11:47633146 NA -0.37 -9.13 -0.34 9.17e-19 Subjective well-being; BRCA cis rs2991971 1.000 rs2993262 chr1:46013733 G/C cg24296786 chr1:45957014 TESK2 0.62 15.39 0.52 1.12e-45 High light scatter reticulocyte count; BRCA trans rs11098499 0.739 rs9996382 chr4:120151012 C/T cg25214090 chr10:38739885 LOC399744 0.45 9.68 0.36 9.14e-21 Corneal astigmatism; BRCA cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg00409905 chr10:38381863 ZNF37A -0.45 -9.86 -0.36 1.86e-21 Extrinsic epigenetic age acceleration; BRCA cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg14024328 chr4:719362 PCGF3 -0.45 -11.49 -0.41 6.88e-28 White blood cell count; BRCA cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg12011299 chr4:100065546 ADH4 0.48 10.76 0.39 6.33e-25 Smoking initiation; BRCA cis rs1953600 0.870 rs2789695 chr10:81946840 C/T cg04850286 chr10:81895943 PLAC9 0.32 9.0 0.34 2.57e-18 Sarcoidosis; BRCA cis rs1165205 0.500 rs629835 chr6:25879330 T/C cg15691649 chr6:25882328 NA -0.45 -8.58 -0.32 7.41e-17 Urate levels; BRCA trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs17270561 0.636 rs9393671 chr6:25789189 G/C cg16482183 chr6:26056742 HIST1H1C -0.41 -8.78 -0.33 1.49e-17 Iron status biomarkers; BRCA cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg18404041 chr3:52824283 ITIH1 0.38 11.57 0.42 3.05e-28 Bipolar disorder; BRCA cis rs2073300 1.000 rs114718317 chr20:23442620 T/C cg12062639 chr20:23401060 NAPB 0.87 10.4 0.38 1.58e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs921968 0.608 rs7598056 chr2:219352511 A/C cg02176678 chr2:219576539 TTLL4 0.38 10.24 0.38 7.1e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs4911259 0.507 rs8118663 chr20:31398876 A/G cg13636640 chr20:31349939 DNMT3B 0.49 11.68 0.42 1.08e-28 Inflammatory bowel disease; BRCA cis rs3784262 0.528 rs34556514 chr15:58333769 A/G cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.68 -0.36 8.65e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6570726 0.846 rs9376954 chr6:145943737 T/A cg23711669 chr6:146136114 FBXO30 0.71 16.94 0.56 1.95e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs11083475 0.557 rs2368519 chr19:39259241 C/T cg07905965 chr19:39260460 NA 0.57 13.79 0.48 4.91e-38 Heart rate; BRCA cis rs11031096 0.727 rs7932702 chr11:4124372 C/T cg18678763 chr11:4115507 RRM1 -0.37 -8.33 -0.31 5.12e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.42 0.61 2.19e-66 Cognitive function; BRCA cis rs11605924 0.792 rs10838524 chr11:45870177 A/G ch.11.939596F chr11:45881766 CRY2 -0.47 -10.12 -0.37 1.93e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10911363 0.592 rs2702203 chr1:183462513 A/T cg09173681 chr1:183549694 NCF2 0.49 10.68 0.39 1.27e-24 Systemic lupus erythematosus; BRCA cis rs9487051 0.834 rs436880 chr6:109553069 C/T cg01475377 chr6:109611718 NA -0.4 -9.6 -0.36 1.75e-20 Reticulocyte fraction of red cells; BRCA cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg13902645 chr11:5959945 NA -0.48 -10.23 -0.38 7.75e-23 DNA methylation (variation); BRCA cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg17628894 chr11:804452 LRDD 0.29 9.28 0.34 2.53e-19 Breast cancer; BRCA cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.97 13.87 0.48 1.97e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4285028 0.948 rs34837785 chr3:121657776 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.61 -11.05 -0.4 4.18e-26 Multiple sclerosis; BRCA cis rs7011049 1.000 rs7011049 chr8:53834012 C/A cg26025543 chr8:53854495 NA 0.54 9.86 0.36 1.85e-21 Systolic blood pressure; BRCA cis rs13190036 1.000 rs71601343 chr5:176632107 G/A cg06733329 chr5:176740039 MXD3 0.46 8.3 0.31 6.26e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs9646954 0.560 rs4149507 chr2:101032745 C/T cg08017756 chr2:100939284 LONRF2 -0.31 -8.02 -0.3 4.88e-15 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg00166722 chr3:10149974 C3orf24 0.65 12.84 0.45 9.71e-34 Alzheimer's disease; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg25427524 chr10:38739819 LOC399744 -0.69 -16.71 -0.55 2.82e-52 Extrinsic epigenetic age acceleration; BRCA cis rs72772090 0.634 rs10515246 chr5:96099265 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.6 -13.2 -0.46 2.34e-35 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.53 -0.35 3.22e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.67 0.45 5.84e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13217239 0.574 rs9366680 chr6:27006123 A/T cg12292205 chr6:26970375 C6orf41 0.54 11.79 0.42 3.62e-29 Schizophrenia; BRCA cis rs2404602 0.647 rs12914196 chr15:76941361 C/T cg23625390 chr15:77176239 SCAPER -0.54 -12.71 -0.45 3.89e-33 Blood metabolite levels; BRCA cis rs17604090 0.701 rs60930239 chr7:29688544 A/G cg19413766 chr7:29689036 LOC646762 -0.5 -8.12 -0.31 2.43e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg00677455 chr12:58241039 CTDSP2 0.56 13.05 0.46 1.18e-34 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg04775059 chr7:64541387 NA 0.44 8.16 0.31 1.79e-15 Calcium levels; BRCA cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg25358565 chr5:93447407 FAM172A 1.21 18.79 0.6 5.1e-63 Diabetic retinopathy; BRCA cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg14343924 chr8:8086146 FLJ10661 0.41 8.32 0.31 5.3e-16 Mood instability; BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg23708337 chr7:1209742 NA 0.6 13.68 0.48 1.45e-37 Longevity;Endometriosis; BRCA trans rs60843830 0.964 rs17713879 chr2:254215 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.62 13.89 0.48 1.66e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg02574844 chr11:5959923 NA 0.41 8.27 0.31 7.85e-16 DNA methylation (variation); BRCA cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA cis rs311392 0.902 rs411371 chr8:55092609 G/A cg11783602 chr8:55087084 NA -0.31 -9.04 -0.34 1.8e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs9325144 0.600 rs2171405 chr12:38741030 G/T cg26384229 chr12:38710491 ALG10B -0.51 -12.31 -0.44 2.19e-31 Morning vs. evening chronotype; BRCA cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg06026331 chr20:60912101 LAMA5 0.44 8.33 0.31 4.8e-16 Colorectal cancer; BRCA cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11644478 chr21:40555479 PSMG1 -0.67 -14.27 -0.49 2.78e-40 Cognitive function; BRCA cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.65 -0.36 1.17e-20 Developmental language disorder (linguistic errors); BRCA cis rs2380220 0.678 rs4308568 chr6:96009525 A/C cg15832292 chr6:96025679 MANEA -0.57 -8.77 -0.33 1.65e-17 Behavioural disinhibition (generation interaction); BRCA cis rs11098499 0.908 rs11098527 chr4:120399906 A/G cg09307838 chr4:120376055 NA 0.72 15.31 0.52 2.61e-45 Corneal astigmatism; BRCA cis rs6121246 0.559 rs6060932 chr20:30350545 A/G cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -12.11 -0.43 1.51e-30 Chronic sinus infection; BRCA cis rs1595825 0.891 rs60484833 chr2:198812181 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -7.95 -0.3 8.24e-15 Ulcerative colitis; BRCA cis rs4285028 0.948 rs12630486 chr3:121685267 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -11.01 -0.4 6.18e-26 Multiple sclerosis; BRCA cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg04450456 chr4:17643702 FAM184B 0.35 9.53 0.35 3.09e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg03264133 chr6:25882463 NA -0.49 -11.01 -0.4 6.3e-26 Blood metabolite levels; BRCA cis rs6815814 0.950 rs66922907 chr4:38812537 A/G cg06935464 chr4:38784597 TLR10 0.51 8.2 0.31 1.32e-15 Breast cancer; BRCA cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg04166393 chr7:2884313 GNA12 0.41 8.68 0.32 3.19e-17 Height; BRCA cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.62 15.61 0.53 9.38e-47 Multiple sclerosis; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg23978390 chr7:1156363 C7orf50 0.38 8.89 0.33 6.28e-18 Longevity;Endometriosis; BRCA cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 0.39 8.9 0.33 5.61e-18 Height;Educational attainment;Head circumference (infant); BRCA cis rs832540 0.564 rs33329 chr5:56145068 T/C cg18230493 chr5:56204884 C5orf35 -0.42 -8.71 -0.33 2.54e-17 Coronary artery disease; BRCA cis rs1448094 0.512 rs7313035 chr12:86250100 C/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.84e-19 Major depressive disorder; BRCA cis rs6700896 0.931 rs11208711 chr1:66147846 G/T cg04111102 chr1:66153794 NA 0.34 8.46 0.32 1.89e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs12612619 0.732 rs13020526 chr2:27204650 C/T cg00617064 chr2:27272375 NA -0.34 -8.86 -0.33 8.02e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg21573476 chr21:45109991 RRP1B -0.37 -9.36 -0.35 1.31e-19 Mean corpuscular volume; BRCA trans rs6582630 0.555 rs10785454 chr12:38476260 C/T cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7828089 0.542 rs7332050 chr8:22265294 G/T cg12081754 chr8:22256438 SLC39A14 0.51 10.33 0.38 2.97e-23 Verbal declarative memory; BRCA cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.78 -13.31 -0.47 7.83e-36 Mean platelet volume; BRCA cis rs6762477 0.748 rs34877766 chr3:50234126 A/G cg24110177 chr3:50126178 RBM5 -0.38 -10.16 -0.37 1.41e-22 Menarche (age at onset); BRCA cis rs62458065 0.513 rs7805536 chr7:32573570 T/C cg20159608 chr7:32802032 NA -0.51 -9.77 -0.36 4.05e-21 Metabolite levels (HVA/MHPG ratio); BRCA cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg11584989 chr19:19387371 SF4 0.64 13.48 0.47 1.25e-36 Bipolar disorder; BRCA cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg18225595 chr11:63971243 STIP1 0.47 8.91 0.33 5.2e-18 Mean platelet volume; BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg08470875 chr2:26401718 FAM59B -0.72 -11.48 -0.41 7.58e-28 Gut microbiome composition (summer); BRCA cis rs6545883 0.894 rs2463102 chr2:61571295 G/C cg15711740 chr2:61764176 XPO1 0.52 13.27 0.46 1.15e-35 Tuberculosis; BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.47 -0.32 1.65e-16 Total body bone mineral density; BRCA cis rs2839186 0.706 rs2839188 chr21:47692798 C/T cg12379764 chr21:47803548 PCNT -0.48 -10.2 -0.37 9.72e-23 Testicular germ cell tumor; BRCA trans rs1005277 0.579 rs1780115 chr10:38524773 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.18 -0.34 5.78e-19 Extrinsic epigenetic age acceleration; BRCA cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg24562669 chr7:97807699 LMTK2 0.44 11.75 0.42 5.51e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.747 rs3753454 chr1:152973776 T/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.85 -0.3 1.74e-14 Inflammatory skin disease; BRCA cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg17143192 chr8:8559678 CLDN23 0.57 11.17 0.4 1.35e-26 Obesity-related traits; BRCA cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg00745463 chr17:30367425 LRRC37B -0.6 -9.77 -0.36 4.04e-21 Hip circumference adjusted for BMI; BRCA cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.63 9.87 0.36 1.8e-21 Lung function (FEV1/FVC); BRCA cis rs4363385 0.740 rs1697428 chr1:153015761 C/A cg24667326 chr1:152973720 SPRR3 -0.33 -8.71 -0.33 2.58e-17 Inflammatory skin disease; BRCA cis rs8114671 0.562 rs1801310 chr20:33517014 A/G cg07148914 chr20:33460835 GGT7 0.47 10.01 0.37 5.42e-22 Height; BRCA cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.28 -0.34 2.52e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 18.52 0.59 1.22e-61 Platelet count; BRCA cis rs11718455 0.960 rs34019365 chr3:44004735 G/A cg08738300 chr3:44038990 NA 0.45 8.7 0.33 2.79e-17 Coronary artery disease; BRCA trans rs2204008 0.805 rs11180825 chr12:38242916 G/T cg06521331 chr12:34319734 NA -0.53 -9.51 -0.35 3.7e-20 Bladder cancer; BRCA cis rs3741151 0.773 rs73542967 chr11:73123512 C/T cg17517138 chr11:73019481 ARHGEF17 0.88 12.73 0.45 3.1e-33 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg11814155 chr7:99998594 ZCWPW1 0.43 8.19 0.31 1.38e-15 Platelet count; BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.62 -0.42 1.89e-28 Lymphocyte counts; BRCA cis rs7766436 0.614 rs7775936 chr6:22566151 T/C cg13666174 chr6:22585274 NA -0.41 -8.66 -0.32 3.86e-17 Coronary artery disease; BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg13047869 chr3:10149882 C3orf24 0.51 11.06 0.4 3.79e-26 Alzheimer's disease; BRCA cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg09904177 chr6:26538194 HMGN4 0.42 11.99 0.43 5.17e-30 Intelligence (multi-trait analysis); BRCA trans rs11088226 0.750 rs2833885 chr21:33923161 A/G cg09050820 chr6:167586206 TCP10L2 0.54 9.32 0.35 1.91e-19 Gastritis; BRCA cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg01877450 chr7:97915802 BRI3 -0.39 -8.93 -0.33 4.63e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg24130564 chr14:104152367 KLC1 0.35 7.82 0.3 2.23e-14 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.59 0.57 9.06e-57 Bladder cancer; BRCA cis rs344364 0.511 rs2982449 chr16:1947878 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg04944784 chr2:26401820 FAM59B -0.95 -16.25 -0.54 5.83e-50 Gut microbiome composition (summer); BRCA cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.39 0.35 1.01e-19 Tonsillectomy; BRCA cis rs9831754 0.906 rs1588650 chr3:78410750 T/G cg06138941 chr3:78371609 NA -0.74 -16.39 -0.54 1.18e-50 Calcium levels; BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.27 -0.31 7.52e-16 Total body bone mineral density; BRCA cis rs1707322 0.752 rs6678444 chr1:46229847 A/G cg03146154 chr1:46216737 IPP 0.53 11.84 0.42 2.3e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg24562669 chr7:97807699 LMTK2 0.47 12.58 0.45 1.38e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24549020 chr5:56110836 MAP3K1 0.41 8.65 0.32 4.22e-17 Initial pursuit acceleration; BRCA cis rs1008375 0.932 rs4698627 chr4:17605959 T/C cg15017067 chr4:17643749 FAM184B 0.28 8.48 0.32 1.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg00825309 chr19:58991885 ZNF446 -0.58 -13.2 -0.46 2.46e-35 Uric acid clearance; BRCA cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg07917127 chr4:99064746 C4orf37 0.42 8.0 0.3 6e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.94e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg08888203 chr3:10149979 C3orf24 0.68 14.46 0.5 3.2e-41 Alzheimer's disease; BRCA cis rs9815354 0.812 rs57209010 chr3:41854743 A/T cg03022575 chr3:42003672 ULK4 0.65 8.98 0.33 2.95e-18 Pulse pressure;Diastolic blood pressure; BRCA cis rs74417235 0.610 rs35212808 chr5:154057808 A/G cg07371521 chr5:154026371 NA 0.41 8.1 0.31 2.79e-15 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs6598955 0.671 rs17162105 chr1:26591255 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs7586879 0.752 rs11683748 chr2:25130434 C/T cg01884057 chr2:25150051 NA 0.31 7.87 0.3 1.51e-14 Body mass index; BRCA cis rs1401999 1.000 rs939337 chr3:183701147 G/C cg20387954 chr3:183756860 HTR3D 0.45 10.09 0.37 2.51e-22 Anterior chamber depth; BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.54 -0.32 9.56e-17 Gut microbiome composition (summer); BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.24 0.59 3.9e-60 Platelet count; BRCA cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg06552810 chr11:31128660 NA -0.38 -8.73 -0.33 2.15e-17 Red blood cell count; BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg23978390 chr7:1156363 C7orf50 0.4 8.17 0.31 1.6e-15 Bronchopulmonary dysplasia; BRCA trans rs2262909 0.925 rs73019900 chr19:22286680 G/A cg17074339 chr11:11642133 GALNTL4 0.44 8.5 0.32 1.33e-16 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs7917772 0.545 rs10786681 chr10:104317357 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.43 0.5 4.39e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs6089829 0.962 rs7267951 chr20:61665979 A/G cg23505145 chr19:12996616 KLF1 0.54 12.19 0.43 7.29e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs7917772 0.582 rs4408249 chr10:104374653 T/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.35 0.49 1.1e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg01689657 chr7:91764605 CYP51A1 0.23 8.51 0.32 1.2e-16 Breast cancer; BRCA cis rs12760731 0.668 rs10913548 chr1:178372286 G/A cg00404053 chr1:178313656 RASAL2 0.7 8.36 0.31 3.93e-16 Obesity-related traits; BRCA cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg22029157 chr1:209979665 IRF6 -0.55 -12.42 -0.44 7e-32 Cleft lip with or without cleft palate; BRCA cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg19784903 chr17:45786737 TBKBP1 -0.4 -10.02 -0.37 4.94e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg11663144 chr21:46675770 NA -0.6 -13.93 -0.48 1.04e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs921968 0.542 rs630858 chr2:219409689 C/A cg02176678 chr2:219576539 TTLL4 0.45 11.86 0.42 1.75e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs35110281 0.686 rs162399 chr21:44950020 G/A cg21573476 chr21:45109991 RRP1B -0.37 -9.35 -0.35 1.43e-19 Mean corpuscular volume; BRCA trans rs1997103 0.911 rs6945663 chr7:55407011 C/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs9944715 0.954 rs9959905 chr18:43811050 A/G cg01718231 chr17:29326311 RNF135 -0.46 -8.84 -0.33 9.57e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.03e-18 Height; BRCA cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs4319547 0.656 rs7397299 chr12:122821649 G/T cg23029597 chr12:123009494 RSRC2 -0.44 -8.98 -0.33 2.9e-18 Body mass index; BRCA cis rs7103648 0.966 rs10769263 chr11:47417183 A/C cg20307385 chr11:47447363 PSMC3 0.86 25.57 0.71 7.1e-100 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs877529 1.000 rs139396 chr22:39538485 G/T cg12193277 chr22:39547181 CBX7 0.46 12.6 0.45 1.1e-32 Multiple myeloma; BRCA cis rs12497850 0.931 rs9311433 chr3:48863835 T/C cg07636037 chr3:49044803 WDR6 0.98 29.06 0.75 6.01e-119 Parkinson's disease; BRCA cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg22800045 chr5:56110881 MAP3K1 0.65 12.34 0.44 1.62e-31 Initial pursuit acceleration; BRCA cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg08999081 chr20:33150536 PIGU 0.47 13.04 0.46 1.22e-34 Glomerular filtration rate (creatinine); BRCA cis rs12549902 0.800 rs7825494 chr8:41507350 C/T cg21772509 chr8:41503840 NKX6-3 0.43 10.4 0.38 1.71e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA trans rs11088226 0.645 rs78172258 chr21:33936539 T/G cg09050820 chr6:167586206 TCP10L2 0.77 13.24 0.46 1.49e-35 Gastritis; BRCA cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg11608241 chr8:8085544 FLJ10661 0.36 9.72 0.36 6.5e-21 Neuroticism; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg18765753 chr7:1198926 ZFAND2A -0.36 -7.97 -0.3 7.28e-15 Longevity;Endometriosis; BRCA cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg05598546 chr1:76251766 SNORD45C;RABGGTB 0.36 9.44 0.35 6.86e-20 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9467773 1.000 rs9393729 chr6:26514166 C/T cg11502198 chr6:26597334 ABT1 0.48 9.52 0.35 3.46e-20 Intelligence (multi-trait analysis); BRCA cis rs10540 1.000 rs35898083 chr11:484469 C/T cg21784768 chr11:537496 LRRC56 -0.66 -8.37 -0.31 3.62e-16 Body mass index; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg04025307 chr7:1156635 C7orf50 0.58 9.0 0.34 2.5e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1451375 0.698 rs11489734 chr7:50635730 A/T cg18232548 chr7:50535776 DDC 0.39 9.26 0.34 3.11e-19 Malaria; BRCA cis rs11763147 1 rs11763147 chr7:65326821 C/T cg11764359 chr7:65958608 NA -0.61 -13.52 -0.47 7.99e-37 Corneal structure; BRCA cis rs7789940 0.951 rs7779014 chr7:75975586 C/T cg10167463 chr7:75959203 YWHAG -0.44 -8.86 -0.33 7.66e-18 Multiple sclerosis; BRCA cis rs853679 0.517 rs9393887 chr6:28059020 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.23 -0.31 1.08e-15 Depression; BRCA cis rs7551345 0.653 rs2377730 chr1:31697779 A/G cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg08085267 chr17:45401833 C17orf57 0.61 12.75 0.45 2.36e-33 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs34779708 0.931 rs2244100 chr10:35323636 G/A cg03585969 chr10:35415529 CREM -0.46 -9.61 -0.36 1.65e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs61931739 0.500 rs11053167 chr12:34387092 A/C cg06521331 chr12:34319734 NA -0.55 -9.97 -0.37 7.12e-22 Morning vs. evening chronotype; BRCA cis rs921968 0.540 rs646295 chr2:219408558 A/C cg02176678 chr2:219576539 TTLL4 0.41 10.97 0.4 9.22e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg18132916 chr6:79620363 NA 0.47 10.93 0.4 1.26e-25 Intelligence (multi-trait analysis); BRCA cis rs2882667 0.518 rs10041986 chr5:138424437 A/G cg04439458 chr5:138467593 SIL1 -0.31 -8.65 -0.32 4.3e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg26373071 chr5:1325741 CLPTM1L 0.49 12.08 0.43 2.13e-30 Lung cancer; BRCA cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -12.17 -0.43 8.58e-31 Intelligence (multi-trait analysis); BRCA cis rs12431939 1.000 rs12432466 chr14:51638873 T/C cg23942311 chr14:51606299 NA -0.44 -8.35 -0.31 4.31e-16 Cancer; BRCA cis rs6121246 0.821 rs6121209 chr20:30311258 G/C cg21427119 chr20:30132790 HM13 -0.43 -8.89 -0.33 6.33e-18 Mean corpuscular hemoglobin; BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg14004847 chr7:1930337 MAD1L1 0.44 9.44 0.35 6.59e-20 Bipolar disorder and schizophrenia; BRCA cis rs2859741 1.000 rs543121 chr1:37497098 T/C cg09363841 chr1:37513479 NA -0.66 -16.5 -0.55 3.44e-51 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs2625529 0.730 rs2957373 chr15:72340929 T/C cg16672083 chr15:72433130 SENP8 0.72 17.18 0.56 1.1e-54 Red blood cell count; BRCA cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs2050392 0.590 rs694346 chr10:30711929 C/T cg18806716 chr10:30721971 MAP3K8 -0.6 -14.12 -0.49 1.3e-39 Inflammatory bowel disease; BRCA cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg26116260 chr4:7069785 GRPEL1 0.93 25.73 0.71 9.81e-101 Monocyte percentage of white cells; BRCA cis rs68170813 0.559 rs80017637 chr7:107050660 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.07 -0.3 3.44e-15 Coronary artery disease; BRCA cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg02297831 chr4:17616191 MED28 -0.37 -7.98 -0.3 6.71e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1568889 0.838 rs4572130 chr11:28371794 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 19.93 0.62 4.13e-69 Bipolar disorder; BRCA cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg18404041 chr3:52824283 ITIH1 -0.35 -9.49 -0.35 4.53e-20 Bipolar disorder; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg02951883 chr7:2050386 MAD1L1 -0.49 -10.84 -0.39 2.98e-25 Bipolar disorder and schizophrenia; BRCA cis rs7762018 1.000 rs6942332 chr6:170131934 A/G cg19338460 chr6:170058176 WDR27 -0.44 -7.97 -0.3 7.26e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg22920501 chr2:26401640 FAM59B -0.61 -10.7 -0.39 1.13e-24 Gut microbiome composition (summer); BRCA cis rs16976116 0.901 rs1061874 chr15:55496287 A/T cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg22875332 chr1:76189707 ACADM 0.64 11.68 0.42 1.08e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7246657 0.941 rs67293224 chr19:37803248 C/T cg18154014 chr19:37997991 ZNF793 0.61 11.1 0.4 2.79e-26 Coronary artery calcification; BRCA cis rs17688601 1.000 rs13230202 chr7:40865219 T/C cg05119115 chr7:40866195 C7orf10 -0.6 -11.68 -0.42 1.1e-28 Pancreatic cancer; BRCA cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.61e-15 Extrinsic epigenetic age acceleration; BRCA cis rs4819052 0.819 rs7279136 chr21:46692287 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1568889 0.938 rs12795971 chr11:28355104 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 13.07 0.46 9.15e-35 Bipolar disorder; BRCA trans rs7746199 0.736 rs10484399 chr6:27534528 A/G cg06606381 chr12:133084897 FBRSL1 -0.78 -7.92 -0.3 1.02e-14 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2652834 1.000 rs2729781 chr15:63404265 T/A cg05507819 chr15:63340323 TPM1 0.45 8.26 0.31 8.31e-16 HDL cholesterol; BRCA cis rs6005807 0.719 rs2881496 chr22:28921265 C/G cg12565055 chr22:29076175 TTC28 -0.41 -7.95 -0.3 8.73e-15 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs838147 0.534 rs2638280 chr19:49209318 G/A cg07051648 chr19:49177693 NTN5;SEC1 -0.43 -8.26 -0.31 8.57e-16 Dietary macronutrient intake; BRCA cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg19346786 chr7:2764209 NA -0.3 -9.42 -0.35 8.35e-20 Height; BRCA trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.2 -18.89 -0.6 1.42e-63 Hemostatic factors and hematological phenotypes; BRCA cis rs4588572 0.643 rs2012562 chr5:77768088 T/A cg11547950 chr5:77652471 NA -0.48 -8.56 -0.32 8.15e-17 Triglycerides; BRCA cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.88 -0.36 1.6e-21 Alzheimer's disease (late onset); BRCA cis rs4948102 0.597 rs12669623 chr7:56139179 G/C cg09872392 chr7:56161020 PHKG1 -0.49 -12.23 -0.44 4.74e-31 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7582180 0.627 rs4149517 chr2:101014247 C/A cg14675211 chr2:100938903 LONRF2 0.44 9.7 0.36 7.48e-21 Intelligence (multi-trait analysis); BRCA cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg08807101 chr21:30365312 RNF160 -0.6 -15.37 -0.52 1.35e-45 Dental caries; BRCA cis rs765787 0.530 rs10851423 chr15:45515950 G/A cg24006582 chr15:45444508 DUOX1 0.55 10.71 0.39 9.9e-25 Uric acid levels; BRCA cis rs9790314 0.746 rs898680 chr3:160772853 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -8.78 -0.33 1.5e-17 Morning vs. evening chronotype; BRCA cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg17063962 chr7:91808500 NA 0.55 13.17 0.46 3.18e-35 Breast cancer; BRCA cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.7e-17 Developmental language disorder (linguistic errors); BRCA trans rs9858542 0.953 rs3811697 chr3:49590770 C/T cg21659725 chr3:3221576 CRBN -0.46 -10.15 -0.37 1.55e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9296092 0.538 rs9469491 chr6:33521545 A/G cg13560919 chr6:33536144 NA 0.84 18.39 0.59 6.5e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs10736390 0.640 rs10888858 chr1:55108978 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.7 -17.06 -0.56 4.59e-54 Survival in pancreatic cancer; BRCA cis rs4906332 1.000 rs78316803 chr14:103942863 A/G cg04998671 chr14:104000505 TRMT61A -0.43 -9.5 -0.35 4.27e-20 Coronary artery disease; BRCA cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg22467129 chr15:76604101 ETFA -0.47 -10.36 -0.38 2.36e-23 Blood metabolite levels; BRCA cis rs908922 0.676 rs578382 chr1:152514054 A/G cg20991723 chr1:152506922 NA -0.38 -8.92 -0.33 4.94e-18 Hair morphology; BRCA cis rs1018836 0.892 rs5005585 chr8:91581975 A/G cg16814680 chr8:91681699 NA -0.56 -12.15 -0.43 1.01e-30 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs911555 0.755 rs2756135 chr14:103962579 G/A cg12935359 chr14:103987150 CKB 0.64 15.0 0.51 8.63e-44 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs7566767 chr2:10754663 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.0 -0.3 6.08e-15 Prostate cancer; BRCA cis rs2404602 0.647 rs11637096 chr15:76931102 T/C cg23625390 chr15:77176239 SCAPER -0.53 -12.65 -0.45 6.52e-33 Blood metabolite levels; BRCA cis rs2115630 0.905 rs6496401 chr15:85297793 A/T cg12863693 chr15:85201151 NMB -0.33 -7.98 -0.3 7.02e-15 P wave terminal force; BRCA cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs617791 0.530 rs735942 chr11:65749337 A/G cg09783858 chr11:65769428 EIF1AD;BANF1 0.47 8.8 0.33 1.24e-17 Breast cancer; BRCA cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.42 -0.32 2.41e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.61 9.36 0.35 1.29e-19 Renal function-related traits (BUN); BRCA cis rs8072100 0.805 rs67919208 chr17:45771873 T/C cg19784903 chr17:45786737 TBKBP1 -0.39 -9.51 -0.35 3.68e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs28735056 0.587 rs8093548 chr18:77636451 G/A cg20368463 chr18:77673604 PQLC1 -0.42 -10.79 -0.39 4.62e-25 Schizophrenia; BRCA cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg05890377 chr2:74357713 NA 0.48 11.65 0.42 1.4e-28 Gestational age at birth (maternal effect); BRCA cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg05925327 chr15:68127851 NA 0.35 8.72 0.33 2.41e-17 Restless legs syndrome; BRCA cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.68 15.05 0.51 5.12e-44 Hip circumference adjusted for BMI; BRCA cis rs739401 0.572 rs384490 chr11:3078885 A/C cg08508325 chr11:3079039 CARS -0.47 -17.81 -0.58 6.52e-58 Longevity; BRCA cis rs17401966 1.000 rs12734068 chr1:10376803 G/A cg15208524 chr1:10270712 KIF1B 0.37 7.89 0.3 1.32e-14 Hepatocellular carcinoma; BRCA cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.28 0.49 2.37e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7432375 0.641 rs1971397 chr3:136527300 C/G cg21827317 chr3:136751795 NA 0.35 7.83 0.3 2.04e-14 Neuroticism;Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs67981189 0.896 rs34049963 chr14:71440746 A/G cg15816911 chr14:71606274 NA 0.35 7.89 0.3 1.29e-14 Schizophrenia; BRCA trans rs208520 0.690 rs12213928 chr6:66762978 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 21.05 0.64 4.24e-75 Exhaled nitric oxide output; BRCA cis rs586533 0.881 rs640790 chr11:99503264 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.34e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg08997352 chr12:9597637 DDX12 -0.58 -11.76 -0.42 4.92e-29 Breast size; BRCA cis rs7647973 0.626 rs9835157 chr3:49797769 G/A cg03060546 chr3:49711283 APEH -0.59 -10.21 -0.37 9.07e-23 Menarche (age at onset); BRCA cis rs7520050 0.966 rs1707321 chr1:46505309 A/G cg24296786 chr1:45957014 TESK2 0.41 9.13 0.34 8.86e-19 Red blood cell count;Reticulocyte count; BRCA cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg11766577 chr21:47581405 C21orf56 -0.4 -8.35 -0.31 4.37e-16 Testicular germ cell tumor; BRCA cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg22800045 chr5:56110881 MAP3K1 0.62 11.85 0.42 2.01e-29 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg17366294 chr4:99064904 C4orf37 -0.45 -10.81 -0.39 3.98e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs427394 0.802 rs200841 chr5:6737134 A/G cg10857441 chr5:6722123 POLS -0.33 -11.0 -0.4 6.52e-26 Menopause (age at onset); BRCA cis rs36051895 0.659 rs72701605 chr9:5062056 G/A cg02405213 chr9:5042618 JAK2 -0.49 -8.91 -0.33 5.44e-18 Pediatric autoimmune diseases; BRCA cis rs9790314 0.871 rs336551 chr3:161109720 T/C cg03342759 chr3:160939853 NMD3 -0.64 -14.31 -0.49 1.69e-40 Morning vs. evening chronotype; BRCA cis rs3771570 1.000 rs62193197 chr2:242294301 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg12751644 chr20:60527061 NA -0.33 -7.95 -0.3 8.44e-15 Body mass index; BRCA cis rs2245008 0.671 rs907036 chr16:83989850 A/T cg07978099 chr16:83986941 OSGIN1 0.36 8.28 0.31 7e-16 Pursuit maintenance gain; BRCA cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg06627628 chr2:24431161 ITSN2 -0.55 -8.89 -0.33 6.25e-18 Lymphocyte counts; BRCA cis rs3784262 0.669 rs2414530 chr15:58356362 T/C cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.55 -0.39 4.3e-24 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs61332075 0.501 rs55706928 chr2:239445806 T/C cg01134436 chr17:81009848 B3GNTL1 0.69 8.99 0.34 2.69e-18 Lung function (FEV1/FVC); BRCA cis rs5758511 0.633 rs5758689 chr22:42664972 T/G cg00645731 chr22:42541494 CYP2D7P1 0.58 10.95 0.4 1.13e-25 Birth weight; BRCA cis rs758324 0.947 rs615305 chr5:131291856 A/G cg06307176 chr5:131281290 NA -0.53 -10.4 -0.38 1.68e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7103648 0.618 rs11039284 chr11:47564785 A/G cg03711944 chr11:47377212 SPI1 -0.44 -10.34 -0.38 2.81e-23 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg04733989 chr22:42467013 NAGA -0.41 -9.6 -0.36 1.77e-20 Cognitive function; BRCA cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg06713675 chr4:122721982 EXOSC9 -0.54 -12.56 -0.44 1.75e-32 Type 2 diabetes; BRCA cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg24812749 chr6:127587940 RNF146 0.88 20.06 0.62 9.03e-70 Breast cancer; BRCA cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg11833968 chr6:79620685 NA -0.43 -9.55 -0.35 2.75e-20 Intelligence (multi-trait analysis); BRCA cis rs12612619 0.732 rs10865461 chr2:27292651 T/C cg00617064 chr2:27272375 NA -0.32 -8.37 -0.31 3.74e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs2760061 0.655 rs686533 chr1:228119604 A/G cg02753203 chr1:228287806 NA -0.6 -13.24 -0.46 1.61e-35 Diastolic blood pressure; BRCA cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA cis rs6121246 0.697 rs6120970 chr20:30232452 C/T cg13852791 chr20:30311386 BCL2L1 0.8 15.06 0.51 4.25e-44 Mean corpuscular hemoglobin; BRCA cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg24838063 chr12:130822603 PIWIL1 0.75 18.55 0.59 8.36e-62 Menopause (age at onset); BRCA cis rs11229555 0.598 rs4519112 chr11:58176386 C/T cg15696309 chr11:58395628 NA -0.45 -9.76 -0.36 4.48e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs477692 0.597 rs574831 chr10:131379190 C/T cg24747557 chr10:131355152 MGMT 0.38 9.6 0.36 1.76e-20 Response to temozolomide; BRCA cis rs495337 1.000 rs2235617 chr20:48554977 C/G cg17835207 chr20:48524531 SPATA2 -0.58 -13.13 -0.46 5e-35 Psoriasis; BRCA cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg22535103 chr8:58192502 C8orf71 -0.61 -13.25 -0.46 1.34e-35 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -14.91 -0.51 2.37e-43 Cognitive function; BRCA cis rs68170813 0.559 rs11764448 chr7:106924928 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.45 -0.32 1.99e-16 Coronary artery disease; BRCA cis rs9468199 0.510 rs72845064 chr6:27654970 C/A cg08851530 chr6:28072375 NA 1.11 10.02 0.37 4.78e-22 Parkinson's disease; BRCA cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg23422044 chr7:1970798 MAD1L1 -0.7 -12.58 -0.45 1.44e-32 Bipolar disorder; BRCA cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg03452623 chr4:187889614 NA -0.31 -10.01 -0.37 5.07e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 0.806 rs1880374 chr3:134322113 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7582180 0.652 rs4851311 chr2:100980398 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.88 -0.3 1.45e-14 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs10017624 chr4:98984009 G/T cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg12432903 chr7:1882776 MAD1L1 0.45 8.03 0.3 4.66e-15 Bipolar disorder; BRCA cis rs9325144 0.723 rs11169535 chr12:39183494 C/T cg26384229 chr12:38710491 ALG10B -0.51 -11.42 -0.41 1.35e-27 Morning vs. evening chronotype; BRCA cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg23711669 chr6:146136114 FBXO30 0.73 16.76 0.55 1.49e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs10876993 0.890 rs12302350 chr12:58062589 T/G cg18357645 chr12:58087776 OS9 0.41 11.43 0.41 1.16e-27 Celiac disease or Rheumatoid arthritis; BRCA cis rs2742234 0.590 rs2503848 chr10:43672785 G/A cg15436174 chr10:43711423 RASGEF1A -0.54 -10.87 -0.4 2.23e-25 Hirschsprung disease; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA trans rs2204008 0.684 rs11514164 chr12:38036494 C/T cg06521331 chr12:34319734 NA -0.54 -10.21 -0.37 8.63e-23 Bladder cancer; BRCA cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg13319975 chr6:146136371 FBXO30 0.41 9.42 0.35 8.08e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7577696 0.524 rs212696 chr2:32441685 A/G cg02381751 chr2:32503542 YIPF4 0.49 8.87 0.33 7.4e-18 Inflammatory biomarkers; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg26516362 chr5:178986906 RUFY1 0.47 13.95 0.48 8.1e-39 Lung cancer; BRCA cis rs6570726 0.935 rs442254 chr6:145849118 T/C cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs1878931 0.580 rs4785932 chr16:3410456 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.88 22.27 0.66 9.04e-82 Body mass index (adult); BRCA cis rs12540874 0.542 rs3807562 chr7:50566671 G/A cg18232548 chr7:50535776 DDC -0.51 -12.97 -0.46 2.61e-34 Systemic sclerosis; BRCA trans rs877282 1.000 rs11253367 chr10:773389 G/A cg22713356 chr15:30763199 NA 1.21 24.66 0.7 7.87e-95 Uric acid levels; BRCA cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.62 10.57 0.39 3.45e-24 Lung function (FEV1/FVC); BRCA cis rs60843830 0.964 rs62114538 chr2:256116 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.76 18.64 0.59 2.92e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs11098499 0.820 rs28578366 chr4:120536905 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.36 -8.49 -0.32 1.4e-16 Corneal astigmatism; BRCA cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -11.52 -0.41 4.93e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -23.45 -0.68 3.31e-88 Gut microbiome composition (summer); BRCA cis rs6545883 0.783 rs7355640 chr2:61845485 C/T cg15711740 chr2:61764176 XPO1 -0.48 -11.71 -0.42 8.09e-29 Tuberculosis; BRCA cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg06713675 chr4:122721982 EXOSC9 -0.54 -12.5 -0.44 3.1e-32 Type 2 diabetes; BRCA cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg11644478 chr21:40555479 PSMG1 -0.68 -15.48 -0.52 3.82e-46 Cognitive function; BRCA cis rs709400 0.627 rs55859054 chr14:103953666 T/A cg12935359 chr14:103987150 CKB -0.57 -13.32 -0.47 6.85e-36 Body mass index; BRCA cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.11 0.31 2.53e-15 Mean platelet volume; BRCA cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg14440974 chr22:39074834 NA -0.38 -9.0 -0.34 2.64e-18 Menopause (age at onset); BRCA cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg00339695 chr16:24857497 SLC5A11 -0.35 -8.03 -0.3 4.85e-15 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs1413848 chr1:152970210 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -8.91 -0.33 5.11e-18 Inflammatory skin disease; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg10729496 chr3:10149963 C3orf24 0.49 9.02 0.34 2.21e-18 Alzheimer's disease; BRCA cis rs6456156 0.792 rs10946215 chr6:167516181 A/G cg07741184 chr6:167504864 NA -0.32 -9.23 -0.34 3.94e-19 Primary biliary cholangitis; BRCA cis rs10045504 0.502 rs17352898 chr5:38745498 C/T cg15396434 chr5:38725168 NA -0.57 -10.77 -0.39 5.62e-25 Night sleep phenotypes; BRCA cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg24531977 chr5:56204891 C5orf35 -0.56 -12.01 -0.43 4.01e-30 Coronary artery disease; BRCA cis rs2901460 0.509 rs35056428 chr2:62061943 A/T cg02183531 chr2:62113199 CCT4 -0.46 -8.93 -0.33 4.4e-18 Mean corpuscular volume; BRCA cis rs9807989 0.507 rs7581119 chr2:103049865 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma; BRCA cis rs600231 0.706 rs1111934 chr11:65329392 A/G cg17120908 chr11:65337727 SSSCA1 -0.52 -9.31 -0.35 2.03e-19 Bone mineral density; BRCA cis rs61931739 0.517 rs4931748 chr12:34140827 C/T cg06521331 chr12:34319734 NA -0.62 -11.35 -0.41 2.62e-27 Morning vs. evening chronotype; BRCA cis rs8062405 0.754 rs62034323 chr16:28536473 C/T cg16576597 chr16:28551801 NUPR1 0.31 8.5 0.32 1.32e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs208520 0.954 rs72884027 chr6:66995044 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.39 0.49 7.25e-41 Exhaled nitric oxide output; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg18402987 chr7:1209562 NA 0.53 9.43 0.35 7.19e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7264396 0.673 rs2425163 chr20:34432670 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -15.13 -0.51 2.04e-44 Total cholesterol levels; BRCA cis rs7246657 0.722 rs968073 chr19:38192021 G/A cg23950597 chr19:37808831 NA 0.51 8.63 0.32 4.82e-17 Coronary artery calcification; BRCA cis rs7301826 0.603 rs7975825 chr12:131288444 C/T cg11011512 chr12:131303247 STX2 0.44 10.84 0.39 2.99e-25 Plasma plasminogen activator levels; BRCA cis rs8072100 1.000 rs7210738 chr17:45757598 G/A cg25173405 chr17:45401733 C17orf57 0.51 10.65 0.39 1.66e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg13628971 chr7:2884303 GNA12 0.46 9.77 0.36 4.01e-21 Height; BRCA cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.77 0.36 4.3e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7103648 0.567 rs12287076 chr11:47606865 G/C cg20307385 chr11:47447363 PSMC3 -0.66 -15.65 -0.53 5.88e-47 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg09065629 chr16:1709722 CRAMP1L 0.37 8.45 0.32 1.96e-16 Coronary artery disease; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg00814883 chr7:100076585 TSC22D4 -0.54 -11.53 -0.41 4.51e-28 Platelet count; BRCA cis rs4481887 0.888 rs12042602 chr1:248482053 C/T cg00666640 chr1:248458726 OR2T12 0.32 8.95 0.33 3.99e-18 Common traits (Other); BRCA cis rs11634851 0.933 rs2627319 chr15:81040330 C/T cg03950166 chr15:80988613 FAM108C1 -0.35 -8.02 -0.3 5.14e-15 Systolic blood pressure; BRCA cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg09658497 chr7:2847517 GNA12 -0.4 -8.41 -0.32 2.7e-16 Height; BRCA cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -9.48 -0.35 4.72e-20 Response to bleomycin (chromatid breaks); BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg22903471 chr2:27725779 GCKR -0.36 -8.77 -0.33 1.65e-17 Total body bone mineral density; BRCA trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg17830980 chr10:43048298 ZNF37B -0.54 -13.16 -0.46 3.53e-35 Extrinsic epigenetic age acceleration; BRCA cis rs17401966 0.838 rs12120042 chr1:10345325 A/T cg03954927 chr1:10346856 KIF1B 0.44 14.09 0.49 1.93e-39 Hepatocellular carcinoma; BRCA cis rs6733011 0.578 rs1581251 chr2:99500867 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.31 -0.31 5.69e-16 Bipolar disorder; BRCA cis rs7267979 0.932 rs2387891 chr20:25470328 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.28 7.82 0.3 2.11e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg09658497 chr7:2847517 GNA12 -0.4 -7.9 -0.3 1.22e-14 Height; BRCA trans rs8073060 0.544 rs225252 chr17:33952401 G/A cg19694781 chr19:47549865 TMEM160 -1.05 -21.07 -0.64 3.14e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs8180040 1.000 rs2159400 chr3:47375890 T/C cg16586182 chr3:47516702 SCAP 0.61 14.02 0.48 4e-39 Colorectal cancer; BRCA cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg00149659 chr3:10157352 C3orf10 1.03 13.81 0.48 3.71e-38 Alzheimer's disease; BRCA cis rs2249625 0.526 rs17725666 chr6:72889711 G/A cg18830697 chr6:72922368 RIMS1 0.66 14.74 0.5 1.59e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg25358565 chr5:93447407 FAM172A 1.15 18.46 0.59 2.7e-61 Diabetic retinopathy; BRCA cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.05 0.3 4.12e-15 Axial length; BRCA cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg24642439 chr20:33292090 TP53INP2 0.53 11.49 0.41 6.56e-28 Glomerular filtration rate (creatinine); BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg08470875 chr2:26401718 FAM59B -0.76 -11.99 -0.43 4.93e-30 Gut microbiome composition (summer); BRCA cis rs2070433 0.752 rs11701058 chr21:47776382 T/C cg12379764 chr21:47803548 PCNT 0.58 10.28 0.38 4.85e-23 Lymphocyte counts; BRCA cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg01689657 chr7:91764605 CYP51A1 0.24 8.48 0.32 1.59e-16 Breast cancer; BRCA cis rs1499972 0.941 rs56256549 chr3:117612102 A/G cg07612923 chr3:117604196 NA 0.6 8.16 0.31 1.78e-15 Schizophrenia; BRCA cis rs12118280 0.612 rs591141 chr1:108694894 A/G cg11967332 chr1:108735228 SLC25A24 0.54 10.21 0.37 9.1e-23 Myeloid white cell count; BRCA cis rs459571 0.959 rs392134 chr9:136909008 G/A cg13789015 chr9:136890014 NCRNA00094 0.73 15.05 0.51 4.88e-44 Platelet distribution width; BRCA cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg13010199 chr12:38710504 ALG10B 0.56 12.22 0.44 5.11e-31 Heart rate; BRCA cis rs6005807 0.719 rs6005809 chr22:28942227 C/T cg12565055 chr22:29076175 TTC28 -0.41 -7.92 -0.3 1.05e-14 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs7927771 0.507 rs10838754 chr11:47758532 A/C cg20307385 chr11:47447363 PSMC3 0.42 9.55 0.35 2.8e-20 Subjective well-being; BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg02951883 chr7:2050386 MAD1L1 -0.38 -8.48 -0.32 1.56e-16 Bipolar disorder and schizophrenia; BRCA cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg11752832 chr7:134001865 SLC35B4 0.52 13.55 0.47 6.19e-37 Mean platelet volume; BRCA cis rs7772486 0.654 rs6906402 chr6:146089307 C/G cg13319975 chr6:146136371 FBXO30 0.45 10.43 0.38 1.24e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs2230307 0.572 rs6677080 chr1:100633469 A/T cg24955406 chr1:100503596 HIAT1 0.46 8.49 0.32 1.5e-16 Carotid intima media thickness; BRCA cis rs2033711 0.755 rs4801587 chr19:58936679 C/A cg26874164 chr19:58962979 ZNF324B 0.43 9.16 0.34 6.7e-19 Uric acid clearance; BRCA trans rs747782 0.527 rs12289516 chr11:48234680 G/A cg15704280 chr7:45808275 SEPT13 0.55 8.05 0.3 4.09e-15 Intraocular pressure; BRCA cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg21361702 chr7:150065534 REPIN1 -0.44 -7.85 -0.3 1.71e-14 Blood protein levels;Circulating chemerin levels; BRCA cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.74 0.33 2.01e-17 Rheumatoid arthritis; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg10150615 chr22:24372951 LOC391322 0.42 9.08 0.34 1.37e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6542838 0.588 rs4851174 chr2:99530113 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -9.25 -0.34 3.25e-19 Fear of minor pain; BRCA cis rs3739998 0.509 rs4749523 chr10:30332445 C/T cg12786570 chr10:30316432 KIAA1462 -0.46 -9.29 -0.34 2.39e-19 Coronary heart disease; BRCA cis rs12477438 0.501 rs2632260 chr2:99771590 G/T cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.46e-23 Chronic sinus infection; BRCA cis rs483180 0.531 rs662243 chr1:120209564 A/C cg19096424 chr1:120255104 PHGDH 0.43 9.44 0.35 6.73e-20 Macular telangiectasia type 2; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg03188948 chr7:1209495 NA 0.58 8.64 0.32 4.5e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg27661571 chr11:113659931 NA -0.5 -8.5 -0.32 1.38e-16 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs9875589 0.509 rs2733548 chr3:14094478 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.97 0.33 3.18e-18 Ovarian reserve; BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg03923535 chr7:1197113 ZFAND2A 0.5 10.08 0.37 2.89e-22 Longevity;Endometriosis; BRCA cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg13175981 chr1:150552382 MCL1 0.54 11.79 0.42 3.56e-29 Tonsillectomy; BRCA cis rs1801251 1.000 rs1022330 chr2:233577330 G/A cg25237894 chr2:233734115 C2orf82 0.38 11.1 0.4 2.62e-26 Coronary artery disease; BRCA cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.14 0.49 1.09e-39 Motion sickness; BRCA cis rs1949733 0.635 rs4358384 chr4:8536913 C/T cg11789530 chr4:8429930 ACOX3 -0.56 -13.13 -0.46 4.85e-35 Response to antineoplastic agents; BRCA cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg11366901 chr6:160182831 ACAT2 0.81 15.96 0.53 1.75e-48 Age-related macular degeneration (geographic atrophy); BRCA trans rs634534 0.562 rs642293 chr11:65730217 G/A cg17712092 chr4:129076599 LARP1B 0.54 13.14 0.46 4.55e-35 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs919433 0.963 rs6738836 chr2:198182432 A/G cg10820045 chr2:198174542 NA -0.39 -8.12 -0.31 2.37e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs17092148 0.887 rs6059936 chr20:33184249 C/T cg16810054 chr20:33298113 TP53INP2 -0.47 -10.67 -0.39 1.46e-24 Neuroticism; BRCA cis rs7264396 0.790 rs3787164 chr20:34228866 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.44 -0.52 6.09e-46 Total cholesterol levels; BRCA cis rs11112613 0.713 rs871220 chr12:105938558 G/A cg03607813 chr12:105948248 NA 0.59 10.82 0.39 3.7e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs6088813 1.000 rs6142359 chr20:33960450 T/C cg14752227 chr20:34000481 UQCC -0.41 -8.71 -0.33 2.57e-17 Height; BRCA cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs4242434 0.927 rs13264187 chr8:22506098 C/T cg03733263 chr8:22462867 KIAA1967 0.91 19.75 0.62 3.88e-68 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs6138458 1.000 rs227627 chr20:24912107 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.66 0.7 7.18e-95 Blood protein levels; BRCA cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg04607235 chr12:12878440 APOLD1 0.55 10.81 0.39 3.78e-25 Pulse pressure; BRCA cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg11062466 chr8:58055876 NA 0.5 8.75 0.33 1.96e-17 Developmental language disorder (linguistic errors); BRCA cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.36 0.35 1.32e-19 Height; BRCA trans rs66573146 0.572 rs66819208 chr4:6946128 A/G cg07817883 chr1:32538562 TMEM39B 0.92 13.93 0.48 1.04e-38 Granulocyte percentage of myeloid white cells; BRCA trans rs10506458 0.915 rs60094497 chr12:63394838 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.24 -20.55 -0.63 2.08e-72 Hemostatic factors and hematological phenotypes; BRCA trans rs1005277 0.691 rs2474558 chr10:38486141 A/C cg17830980 chr10:43048298 ZNF37B 0.45 9.88 0.36 1.6e-21 Extrinsic epigenetic age acceleration; BRCA cis rs6089584 0.854 rs2380146 chr20:60632233 C/T cg06108461 chr20:60628389 TAF4 -0.97 -22.03 -0.66 1.96e-80 Body mass index; BRCA cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg05340658 chr4:99064831 C4orf37 0.59 11.9 0.43 1.29e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs6840360 0.571 rs4696273 chr4:152528477 G/A cg22705602 chr4:152727874 NA -0.32 -8.14 -0.31 2.04e-15 Intelligence (multi-trait analysis); BRCA cis rs2637030 0.559 rs256116 chr5:52962251 C/T cg06476337 chr5:52856530 NDUFS4 0.35 7.96 0.3 8.08e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg16482183 chr6:26056742 HIST1H1C 0.55 11.52 0.41 4.98e-28 Height; BRCA cis rs4629180 1.000 rs4851457 chr2:102091220 C/T cg04415270 chr2:102091202 RFX8 0.35 8.35 0.31 4.08e-16 Chronic rhinosinusitis with nasal polyps; BRCA cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg17420585 chr12:42539391 GXYLT1 -0.4 -8.33 -0.31 4.88e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg02951883 chr7:2050386 MAD1L1 -0.61 -15.14 -0.51 1.71e-44 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg13319975 chr6:146136371 FBXO30 0.4 9.08 0.34 1.38e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg17892150 chr10:133769511 PPP2R2D -0.73 -15.49 -0.52 3.39e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg17971929 chr21:40555470 PSMG1 -0.62 -14.42 -0.5 5.12e-41 Cognitive function; BRCA cis rs10504229 0.906 rs72650894 chr8:58179734 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs11190604 1.000 rs11190599 chr10:102295420 C/T cg07080220 chr10:102295463 HIF1AN 0.63 14.98 0.51 1.08e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7727544 0.735 rs270605 chr5:131651811 C/T cg07395648 chr5:131743802 NA -0.38 -9.48 -0.35 4.89e-20 Blood metabolite levels; BRCA cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11890956 chr21:40555474 PSMG1 -0.62 -13.8 -0.48 4.27e-38 Menarche (age at onset); BRCA cis rs897080 0.515 rs1067325 chr2:44628997 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.43 0.35 7.21e-20 Height; BRCA cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg10523679 chr1:76189770 ACADM 0.7 12.33 0.44 1.8e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11605275 0.581 rs11606785 chr11:20030430 A/C cg14835545 chr11:20032148 NAV2 -0.64 -9.0 -0.34 2.58e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1538970 1.000 rs61791368 chr1:45867944 T/C cg05343316 chr1:45956843 TESK2 0.62 12.4 0.44 8.18e-32 Platelet count; BRCA cis rs8177253 0.665 rs9869257 chr3:133451412 G/T cg01448562 chr3:133502909 NA -0.41 -9.41 -0.35 9.13e-20 Iron status biomarkers; BRCA cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg05340658 chr4:99064831 C4orf37 0.68 17.2 0.56 8.57e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9309711 0.883 rs13429373 chr2:3477014 G/A cg16153549 chr2:3496821 NA -0.4 -9.1 -0.34 1.1e-18 Neurofibrillary tangles; BRCA cis rs875971 0.564 rs313804 chr7:65514622 A/G cg12463550 chr7:65579703 CRCP 0.37 7.9 0.3 1.23e-14 Aortic root size; BRCA cis rs6831352 0.744 rs2602847 chr4:100025963 T/C cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Alcohol dependence; BRCA cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg24060327 chr5:131705240 SLC22A5 -0.49 -10.17 -0.37 1.28e-22 Blood metabolite levels; BRCA cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg06636001 chr8:8085503 FLJ10661 0.58 13.15 0.46 3.99e-35 Mood instability; BRCA cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.82 -0.3 2.21e-14 Electroencephalogram traits; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13012494 chr21:47604986 C21orf56 -0.44 -8.89 -0.33 6.35e-18 Testicular germ cell tumor; BRCA cis rs10501293 1.000 rs10501293 chr11:43086094 G/T cg03447554 chr11:43094025 NA 0.48 9.03 0.34 2.09e-18 Cognitive performance; BRCA cis rs11711311 1.000 rs9854504 chr3:113532381 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -10.41 -0.38 1.51e-23 IgG glycosylation; BRCA cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg23625390 chr15:77176239 SCAPER 0.4 9.38 0.35 1.17e-19 Blood metabolite levels; BRCA cis rs9325144 0.560 rs1843911 chr12:38676585 C/T cg13010199 chr12:38710504 ALG10B -0.37 -8.95 -0.33 3.81e-18 Morning vs. evening chronotype; BRCA cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg27286337 chr10:134555280 INPP5A 0.64 11.23 0.41 7.67e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.67 0.5 3.35e-42 Colorectal cancer; BRCA cis rs4889855 0.530 rs12946972 chr17:78618922 A/G cg16591659 chr17:78472290 NA -0.32 -8.14 -0.31 2e-15 Fractional excretion of uric acid; BRCA trans rs12458462 0.892 rs2242175 chr18:77464406 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -8.62 -0.32 5.42e-17 Monocyte count; BRCA cis rs12142240 0.692 rs7532149 chr1:46824932 A/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs11098499 0.775 rs67281037 chr4:120281157 G/C cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA trans rs1941687 0.509 rs7238029 chr18:31317755 A/G cg15819921 chr19:927150 ARID3A -0.46 -8.53 -0.32 1.07e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs11088226 0.681 rs2833903 chr21:33940819 C/T cg09050820 chr6:167586206 TCP10L2 0.77 13.18 0.46 2.77e-35 Gastritis; BRCA cis rs9467711 0.591 rs35249036 chr6:26026163 C/G cg08501292 chr6:25962987 TRIM38 0.59 8.03 0.3 4.71e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6840360 0.571 rs62327268 chr4:152522326 T/A cg22705602 chr4:152727874 NA -0.33 -8.22 -0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs4453662 chr2:10739128 G/A cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 17.95 0.58 1.16e-58 Platelet count; BRCA cis rs12500482 0.935 rs12644638 chr4:2413461 C/T cg26605046 chr4:2439731 NA -0.4 -9.31 -0.35 2.07e-19 Cognitive function; BRCA cis rs9287719 0.967 rs6712406 chr2:10754420 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg12923728 chr3:195709715 SDHAP1 -0.59 -12.46 -0.44 4.85e-32 Pancreatic cancer; BRCA cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg08564027 chr20:61660810 NA 0.83 21.84 0.65 2.18e-79 Prostate cancer (SNP x SNP interaction); BRCA cis rs796364 0.806 rs55985986 chr2:201120987 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.58 -8.37 -0.31 3.75e-16 Schizophrenia; BRCA cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg05340658 chr4:99064831 C4orf37 0.66 16.11 0.54 3.1e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -14.19 -0.49 6.36e-40 Cognitive function; BRCA cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg10523679 chr1:76189770 ACADM -0.45 -8.06 -0.3 3.69e-15 Daytime sleep phenotypes; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg15017067 chr4:17643749 FAM184B 0.33 9.68 0.36 8.88e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9858542 0.903 rs11921590 chr3:49644193 T/C cg21659725 chr3:3221576 CRBN -0.49 -10.44 -0.38 1.11e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.04 0.4 4.63e-26 Bipolar disorder; BRCA cis rs12200560 0.505 rs11153095 chr6:97078592 T/C cg06623918 chr6:96969491 KIAA0776 -0.46 -10.65 -0.39 1.65e-24 Coronary heart disease; BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.21 20.12 0.62 3.97e-70 Platelet count; BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg00080972 chr5:178986291 RUFY1 0.47 12.46 0.44 4.73e-32 Lung cancer; BRCA cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.33 -8.01 -0.3 5.32e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs34779708 0.658 rs4934715 chr10:35364992 G/T cg03585969 chr10:35415529 CREM 0.5 10.46 0.38 9.93e-24 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7659604 0.840 rs6821305 chr4:122713863 A/C cg19748678 chr4:122722346 EXOSC9 0.47 10.41 0.38 1.57e-23 Type 2 diabetes; BRCA cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.74e-30 Tonsillectomy; BRCA cis rs34172651 0.617 rs9922436 chr16:24704490 C/G cg00339695 chr16:24857497 SLC5A11 0.36 7.85 0.3 1.76e-14 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg21573476 chr21:45109991 RRP1B -0.33 -8.68 -0.32 3.22e-17 Mean corpuscular volume; BRCA cis rs2762353 0.902 rs3799344 chr6:25786993 C/T cg03264133 chr6:25882463 NA 0.41 9.61 0.36 1.6e-20 Blood metabolite levels; BRCA cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg12386194 chr3:101231763 SENP7 0.45 9.45 0.35 6.14e-20 Colorectal cancer; BRCA cis rs763121 0.853 rs3747174 chr22:39069181 T/C cg21395723 chr22:39101663 GTPBP1 0.39 8.33 0.31 4.9e-16 Menopause (age at onset); BRCA cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.4 8.0 0.3 5.88e-15 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.08 30.61 0.77 2.13e-127 Cognitive ability; BRCA cis rs208515 0.525 rs4145045 chr6:66678949 T/C cg07460842 chr6:66804631 NA 0.77 14.02 0.48 4.08e-39 Exhaled nitric oxide levels; BRCA cis rs1997103 1.000 rs6966183 chr7:55407546 A/C cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6060717 0.536 rs2425104 chr20:34312346 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Hip circumference adjusted for BMI; BRCA cis rs2635047 1.000 rs2635045 chr18:44668417 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.41 9.01 0.34 2.41e-18 Educational attainment; BRCA cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg08493051 chr2:3487164 NA -0.41 -8.34 -0.31 4.59e-16 Neurofibrillary tangles; BRCA cis rs7945718 0.967 rs12417886 chr11:12811731 A/C cg25843174 chr11:12811716 TEAD1 -0.25 -9.53 -0.35 3.12e-20 Educational attainment (years of education); BRCA cis rs11971779 0.680 rs6961812 chr7:139043808 A/C cg07862535 chr7:139043722 LUC7L2 0.38 10.37 0.38 2.13e-23 Diisocyanate-induced asthma; BRCA cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg10845886 chr2:3471009 TTC15 -0.54 -12.07 -0.43 2.23e-30 Neurofibrillary tangles; BRCA cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.28 0.31 7.49e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg15112475 chr7:1198522 ZFAND2A -0.56 -13.95 -0.48 8.07e-39 Longevity;Endometriosis; BRCA cis rs412000 0.553 rs2680702 chr17:56431549 A/G cg25039879 chr17:56429692 SUPT4H1 0.36 7.85 0.3 1.71e-14 Primary tooth development (time to first tooth eruption); BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg21226059 chr5:178986404 RUFY1 0.47 12.69 0.45 4.58e-33 Lung cancer; BRCA cis rs7584330 0.910 rs6713555 chr2:238398182 A/G cg14458575 chr2:238380390 NA -0.52 -11.71 -0.42 8.09e-29 Prostate cancer; BRCA cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg18132916 chr6:79620363 NA -0.48 -11.02 -0.4 5.75e-26 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg03146154 chr1:46216737 IPP 0.51 11.14 0.4 1.86e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA trans rs1005277 0.602 rs1740743 chr10:38519222 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.18 -0.34 5.78e-19 Extrinsic epigenetic age acceleration; BRCA cis rs10492096 0.947 rs61918020 chr12:6605514 C/T cg13857086 chr12:6580257 VAMP1 0.43 8.45 0.32 2.01e-16 Hip geometry; BRCA cis rs7666738 0.784 rs4699602 chr4:99034903 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.67 0.55 4.74e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs7944584 0.552 rs12361415 chr11:47474146 T/G cg20307385 chr11:47447363 PSMC3 0.75 16.4 0.54 1.03e-50 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.68 14.15 0.49 9.69e-40 Chronic sinus infection; BRCA cis rs10789491 1.000 rs1545206 chr1:47185082 C/G cg15501359 chr1:47185051 KIAA0494 0.66 18.21 0.58 5.23e-60 Response to hepatitis C treatment; BRCA cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -14.13 -0.49 1.17e-39 Hemoglobin concentration; BRCA cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg08109568 chr15:31115862 NA -0.47 -10.84 -0.39 2.96e-25 Huntington's disease progression; BRCA cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg11663144 chr21:46675770 NA -0.64 -15.28 -0.52 3.72e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg00149659 chr3:10157352 C3orf10 0.8 13.88 0.48 1.79e-38 Alzheimer's disease; BRCA cis rs477692 0.699 rs509017 chr10:131367174 T/G cg05714579 chr10:131428358 MGMT 0.5 10.98 0.4 8.55e-26 Response to temozolomide; BRCA cis rs798766 1.000 rs798767 chr4:1734281 A/G cg10756475 chr4:1757242 NA 0.37 8.39 0.31 3.21e-16 Bladder cancer;Urinary bladder cancer; BRCA cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg01579765 chr21:45077557 HSF2BP -0.34 -9.01 -0.34 2.35e-18 Mean corpuscular volume; BRCA cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg16584290 chr5:462447 EXOC3 0.53 14.58 0.5 9.26e-42 Cystic fibrosis severity; BRCA cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs2797160 0.967 rs2226158 chr6:125995467 C/T cg05901451 chr6:126070800 HEY2 -0.48 -11.52 -0.41 4.85e-28 Endometrial cancer; BRCA trans rs35110281 0.667 rs9941787 chr21:45116042 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.21 0.34 4.47e-19 Mean corpuscular volume; BRCA cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.14 0.31 2.07e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg12935359 chr14:103987150 CKB -0.59 -13.92 -0.48 1.19e-38 Body mass index; BRCA cis rs7246657 0.943 rs6508733 chr19:38000548 A/T cg18154014 chr19:37997991 ZNF793 0.53 10.64 0.39 1.82e-24 Coronary artery calcification; BRCA cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs4478037 0.822 rs9827863 chr3:33118951 C/T cg19404215 chr3:33155277 CRTAP -0.41 -8.44 -0.32 2.12e-16 Major depressive disorder; BRCA cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg08992911 chr2:238395768 MLPH 0.38 8.34 0.31 4.68e-16 Prostate cancer; BRCA cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.4 0.57 8.33e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg16006841 chr5:176797999 RGS14 -0.79 -15.63 -0.53 7.53e-47 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs2522056 1.000 rs62385693 chr5:131773674 T/C cg24060327 chr5:131705240 SLC22A5 0.45 7.9 0.3 1.23e-14 Lymphocyte counts;Fibrinogen; BRCA cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg20701182 chr2:24300061 SF3B14 0.59 9.24 0.34 3.67e-19 Lymphocyte counts; BRCA cis rs11583043 0.918 rs17525451 chr1:101422409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.66 0.36 1.03e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs6973256 0.865 rs763645 chr7:133343428 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg16325326 chr1:53192061 ZYG11B -0.95 -26.57 -0.72 2.4e-105 Monocyte count; BRCA cis rs2204008 0.715 rs12815986 chr12:38343869 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.31 0.57 2.38e-55 Bladder cancer; BRCA cis rs1499972 0.941 rs62263114 chr3:117617722 T/A cg07612923 chr3:117604196 NA 0.58 7.87 0.3 1.54e-14 Schizophrenia; BRCA cis rs4363385 0.818 rs946096 chr1:153006529 T/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs926392 0.666 rs912179 chr20:37710775 G/A cg16355469 chr20:37678765 NA 0.43 9.96 0.37 7.78e-22 Dialysis-related mortality; BRCA cis rs1003719 0.788 rs2835586 chr21:38461326 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.03 0.49 3.72e-39 Eye color traits; BRCA cis rs752010 0.644 rs7541348 chr1:42113215 T/G cg06885757 chr1:42089581 HIVEP3 0.26 9.12 0.34 9.73e-19 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6088580 0.660 rs6087592 chr20:33114503 A/G cg08999081 chr20:33150536 PIGU 0.44 12.24 0.44 4.12e-31 Glomerular filtration rate (creatinine); BRCA cis rs11931598 0.513 rs3857170 chr4:7003366 A/T cg26116260 chr4:7069785 GRPEL1 0.32 7.9 0.3 1.2e-14 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; BRCA cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg25358565 chr5:93447407 FAM172A 1.19 17.77 0.58 1.07e-57 Diabetic retinopathy; BRCA cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs12549902 0.966 rs4737000 chr8:41509727 A/C cg21772509 chr8:41503840 NKX6-3 0.48 11.32 0.41 3.34e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs56176327 0.583 rs7613603 chr3:49812866 C/T cg07636037 chr3:49044803 WDR6 -0.5 -8.25 -0.31 9.35e-16 Intelligence (multi-trait analysis); BRCA cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg00271210 chr6:167070053 RPS6KA2 -0.32 -8.59 -0.32 6.72e-17 Crohn's disease; BRCA cis rs6063312 0.518 rs6122718 chr20:47346225 A/G cg18078177 chr20:47281410 PREX1 -0.69 -16.94 -0.56 2.02e-53 Tonometry; BRCA cis rs317689 0.918 rs689415 chr12:69738139 A/G cg14784868 chr12:69753453 YEATS4 -0.42 -8.24 -0.31 9.770000000000001e-16 Response to diuretic therapy; BRCA cis rs9644630 0.658 rs4427190 chr8:19321385 C/T cg06562184 chr8:19319451 CSGALNACT1 -0.33 -7.88 -0.3 1.44e-14 Oropharynx cancer; BRCA cis rs3857067 0.806 rs12513267 chr4:95109545 C/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.39 -0.35 1.02e-19 QT interval; BRCA cis rs6570726 0.935 rs367643 chr6:145859602 A/C cg23711669 chr6:146136114 FBXO30 0.63 14.8 0.51 7.87e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs2859741 0.967 rs822854 chr1:37485788 A/G cg09363841 chr1:37513479 NA -0.64 -16.23 -0.54 7.32e-50 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs3768617 0.966 rs10797850 chr1:183094802 G/A ch.1.3577855R chr1:183094577 LAMC1 0.46 10.27 0.38 5.24e-23 Fuchs's corneal dystrophy; BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg00814883 chr7:100076585 TSC22D4 -0.49 -10.37 -0.38 2.07e-23 Platelet count; BRCA cis rs1707322 0.963 rs12076580 chr1:46258159 G/A cg03146154 chr1:46216737 IPP 0.53 11.57 0.42 2.94e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4853036 1.000 rs4853036 chr2:70059824 G/A cg02498382 chr2:70120550 SNRNP27 -0.44 -8.84 -0.33 9.6e-18 Colorectal or endometrial cancer; BRCA cis rs7633857 0.512 rs745707 chr3:160652672 G/T cg03342759 chr3:160939853 NMD3 -0.52 -10.92 -0.4 1.45e-25 Educational attainment (years of education); BRCA trans rs8002861 0.619 rs9562516 chr13:44431738 T/C cg12856521 chr11:46389249 DGKZ 0.4 8.71 0.33 2.51e-17 Leprosy; BRCA cis rs61931739 0.500 rs12371415 chr12:34521362 C/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.1e-22 Morning vs. evening chronotype; BRCA cis rs4594175 0.926 rs11851960 chr14:51598610 A/G cg23942311 chr14:51606299 NA 0.34 8.47 0.32 1.72e-16 Cancer; BRCA cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg11764359 chr7:65958608 NA -0.78 -18.87 -0.6 1.8e-63 Aortic root size; BRCA cis rs703842 0.739 rs701008 chr12:58117645 A/G cg00677455 chr12:58241039 CTDSP2 0.46 10.35 0.38 2.51e-23 Multiple sclerosis; BRCA cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg03060546 chr3:49711283 APEH -0.51 -10.38 -0.38 2.04e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 0.31 9.8 0.36 3.21e-21 Autism spectrum disorder or schizophrenia; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.15 -0.31 1.89e-15 Total body bone mineral density; BRCA cis rs832540 0.656 rs702689 chr5:56177443 G/A cg24531977 chr5:56204891 C5orf35 -0.51 -10.52 -0.38 5.38e-24 Coronary artery disease; BRCA cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg18016565 chr1:150552671 MCL1 0.34 7.83 0.3 2.06e-14 Melanoma; BRCA cis rs921968 0.541 rs667251 chr2:219384384 C/G cg02176678 chr2:219576539 TTLL4 0.46 11.94 0.43 8.48e-30 Mean corpuscular hemoglobin concentration; BRCA trans rs634534 0.591 rs688862 chr11:65733393 A/G cg17712092 chr4:129076599 LARP1B 0.49 12.05 0.43 2.96e-30 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg08992911 chr2:238395768 MLPH 0.54 8.29 0.31 6.93e-16 Prostate cancer; BRCA cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg23583168 chr7:148888333 NA -0.85 -19.79 -0.62 2.44e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9399135 1.000 rs11754265 chr6:135356216 C/G cg24558204 chr6:135376177 HBS1L 0.44 11.89 0.43 1.41e-29 Red blood cell count; BRCA cis rs11792861 0.926 rs76689835 chr9:111833792 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.18 0.31 1.48e-15 Menarche (age at onset); BRCA cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg14530993 chr4:882597 GAK 0.42 8.23 0.31 1.07e-15 Intelligence (multi-trait analysis); BRCA cis rs1865760 1.000 rs9467636 chr6:25919549 A/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.55 0.39 4.23e-24 Height; BRCA cis rs1005277 0.579 rs2749612 chr10:38488610 G/A cg00409905 chr10:38381863 ZNF37A -0.5 -10.5 -0.38 6.43e-24 Extrinsic epigenetic age acceleration; BRCA cis rs9393692 0.846 rs7771202 chr6:26279907 A/G cg00631329 chr6:26305371 NA -0.42 -12.61 -0.45 1.07e-32 Educational attainment; BRCA cis rs881375 0.678 rs10760130 chr9:123701990 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.55 0.42 3.76e-28 Rheumatoid arthritis; BRCA cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg08601574 chr20:25228251 PYGB -0.35 -8.3 -0.31 6.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg03060546 chr3:49711283 APEH 0.5 10.93 0.4 1.34e-25 Resting heart rate; BRCA cis rs3008870 1.000 rs2985821 chr1:67403787 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.99 22.65 0.67 8.12e-84 Lymphocyte percentage of white cells; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg23131131 chr22:24373011 LOC391322 -0.46 -11.16 -0.4 1.45e-26 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.68 0.45 5e-33 Mean platelet volume; BRCA cis rs7772486 0.686 rs1292336 chr6:145967818 T/C cg23711669 chr6:146136114 FBXO30 -0.7 -16.72 -0.55 2.38e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs16976116 0.901 rs28541469 chr15:55500788 G/A cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1997103 0.871 rs1997100 chr7:55399656 C/G cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA trans rs9329221 0.686 rs35840352 chr8:10239807 A/G cg15556689 chr8:8085844 FLJ10661 0.38 9.18 0.34 6.14e-19 Neuroticism; BRCA cis rs208520 0.690 rs4386800 chr6:66755242 A/G cg07460842 chr6:66804631 NA 0.98 19.66 0.61 1.18e-67 Exhaled nitric oxide output; BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.52 8.63 0.32 5.05e-17 Renal function-related traits (BUN); BRCA cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg17063962 chr7:91808500 NA 0.52 12.38 0.44 1.1e-31 Breast cancer; BRCA cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg11764359 chr7:65958608 NA -0.65 -14.3 -0.49 1.84e-40 Aortic root size; BRCA cis rs912057 0.526 rs746453 chr6:6734221 C/A cg06612196 chr6:6737390 NA 0.56 13.28 0.47 9.91e-36 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg04025307 chr7:1156635 C7orf50 -0.69 -17.04 -0.56 5.94e-54 Longevity;Endometriosis; BRCA cis rs59918340 0.728 rs10112337 chr8:142233573 A/G cg23750338 chr8:142222470 SLC45A4 -0.52 -12.63 -0.45 8.12e-33 Immature fraction of reticulocytes; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg18402987 chr7:1209562 NA 0.41 8.26 0.31 8.1e-16 Longevity;Endometriosis; BRCA cis rs13046373 0.508 rs1012969 chr21:31996108 G/A cg14062083 chr21:31802829 KRTAP13-4 0.34 9.27 0.34 2.93e-19 HDL cholesterol; BRCA cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg24130564 chr14:104152367 KLC1 -0.6 -16.71 -0.55 2.83e-52 Intelligence (multi-trait analysis); BRCA cis rs10181042 0.565 rs3108630 chr2:61268160 A/G cg15711740 chr2:61764176 XPO1 0.36 9.2 0.34 5.2e-19 Crohn's disease; BRCA cis rs11169225 0.724 rs7305290 chr12:50341465 A/G cg04450003 chr12:50355995 AQP5 0.42 8.86 0.33 7.64e-18 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg14689365 chr7:158441557 NCAPG2 0.39 8.05 0.3 3.95e-15 Height; BRCA cis rs4727027 0.933 rs917122 chr7:148848257 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.52 0.32 1.17e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs11039798 0.582 rs1483119 chr11:48382334 A/G cg15704280 chr7:45808275 SEPT13 -0.57 -9.66 -0.36 1.04e-20 Axial length; BRCA cis rs7737355 0.898 rs4706030 chr5:130957486 A/G cg06307176 chr5:131281290 NA 0.52 10.21 0.37 8.78e-23 Life satisfaction; BRCA cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg03709012 chr19:19516395 GATAD2A -0.8 -18.91 -0.6 1.07e-63 Tonsillectomy; BRCA cis rs6964587 0.610 rs6465338 chr7:91450624 T/C cg17063962 chr7:91808500 NA 0.54 12.3 0.44 2.35e-31 Breast cancer; BRCA trans rs35110281 0.774 rs162404 chr21:44963264 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.11 0.31 2.58e-15 Mean corpuscular volume; BRCA cis rs367943 1.000 rs348944 chr5:112822925 C/T cg12552261 chr5:112820674 MCC -0.55 -12.07 -0.43 2.28e-30 Type 2 diabetes; BRCA cis rs2859741 0.528 rs6686296 chr1:37489380 G/T cg09363841 chr1:37513479 NA 0.5 10.9 0.4 1.79e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.25 -0.38 6.25e-23 Initial pursuit acceleration; BRCA cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg08219700 chr8:58056026 NA 0.53 12.29 0.44 2.67e-31 Developmental language disorder (linguistic errors); BRCA cis rs4927850 0.958 rs1975582 chr3:195751439 G/T cg00031303 chr3:195681400 NA 0.46 8.6 0.32 6.32e-17 Pancreatic cancer; BRCA cis rs4285028 1.000 rs4285028 chr3:121660664 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.61 -11.24 -0.41 7.02e-27 Multiple sclerosis; BRCA cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.46 -10.46 -0.38 9.82e-24 Aortic root size; BRCA cis rs2637030 0.559 rs423014 chr5:52894598 A/G cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs7255436 1.000 rs7255436 chr19:8433196 C/A cg10174797 chr19:8464628 RAB11B 0.35 8.85 0.33 8.35e-18 HDL cholesterol; BRCA cis rs6750047 0.546 rs2082255 chr2:38273758 C/A cg07380506 chr2:38303506 CYP1B1 0.48 10.54 0.38 4.58e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg06671706 chr8:8559999 CLDN23 0.43 8.3 0.31 6.23e-16 Obesity-related traits; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg16145915 chr7:1198662 ZFAND2A 0.49 11.03 0.4 5.17e-26 Longevity;Endometriosis; BRCA cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg01579765 chr21:45077557 HSF2BP -0.43 -11.44 -0.41 1.04e-27 Mean corpuscular volume; BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.56 11.53 0.42 4.35e-28 Lymphocyte counts; BRCA cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg20503657 chr10:835505 NA 0.93 16.59 0.55 1.08e-51 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11890956 chr21:40555474 PSMG1 1.04 29.76 0.76 8.7e-123 Cognitive function; BRCA cis rs919433 0.680 rs788018 chr2:198265526 A/G cg00792783 chr2:198669748 PLCL1 0.38 8.52 0.32 1.11e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg26818010 chr10:134567672 INPP5A -0.78 -15.53 -0.52 2.14e-46 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7917772 0.582 rs3977756 chr10:104398582 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -9.99 -0.37 6.07e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg05863683 chr7:1912471 MAD1L1 0.41 8.62 0.32 5.42e-17 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs2011503 0.739 rs10412176 chr19:19689164 T/C cg11584989 chr19:19387371 SF4 -0.48 -9.84 -0.36 2.23e-21 Bipolar disorder; BRCA cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg00852783 chr1:26633632 UBXN11 0.51 11.0 0.4 6.85e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs4742903 0.933 rs10820608 chr9:106890840 A/G cg14250997 chr9:106856677 SMC2 0.35 11.17 0.4 1.32e-26 High-grade serous ovarian cancer;Breast cancer; BRCA trans rs6582630 0.519 rs11609739 chr12:38547969 G/A cg06521331 chr12:34319734 NA -0.51 -9.27 -0.34 2.75e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg16230307 chr14:35515116 FAM177A1 0.69 14.5 0.5 2.22e-41 Psoriasis; BRCA cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.95 0.3 8.55e-15 Parkinson's disease; BRCA cis rs10504073 0.647 rs7817571 chr8:50003218 T/C cg00325661 chr8:49890786 NA 0.39 11.44 0.41 1.05e-27 Blood metabolite ratios; BRCA cis rs16976116 0.855 rs28522816 chr15:55495114 C/G cg11288833 chr15:55489084 RSL24D1 0.48 10.68 0.39 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg23533926 chr12:111358616 MYL2 -0.43 -9.14 -0.34 8.32e-19 Extrinsic epigenetic age acceleration; BRCA trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg08975724 chr8:8085496 FLJ10661 -0.39 -7.9 -0.3 1.25e-14 Neuroticism; BRCA trans rs2840044 1.000 rs2840044 chr17:33892068 A/G cg19694781 chr19:47549865 TMEM160 0.45 10.65 0.39 1.76e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs6977660 0.714 rs10249477 chr7:19805388 T/A cg07541023 chr7:19748670 TWISTNB 0.57 9.72 0.36 6.52e-21 Thyroid stimulating hormone; BRCA cis rs796364 0.806 rs12616905 chr2:201007764 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.87 0.4 2.21e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg20503657 chr10:835505 NA 1.05 18.42 0.59 4.21e-61 Eosinophil percentage of granulocytes; BRCA cis rs10927875 0.631 rs945418 chr1:16344730 T/C cg21385522 chr1:16154831 NA 0.46 8.43 0.32 2.37e-16 Dilated cardiomyopathy; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg21782813 chr7:2030301 MAD1L1 0.39 10.04 0.37 4.01e-22 Bipolar disorder and schizophrenia; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg04025307 chr7:1156635 C7orf50 0.45 10.61 0.39 2.44e-24 Longevity;Endometriosis; BRCA cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg21918786 chr6:109611834 NA -0.49 -14.14 -0.49 1.03e-39 Reticulocyte fraction of red cells; BRCA cis rs372883 0.648 rs382732 chr21:30719010 A/G cg24692254 chr21:30365293 RNF160 0.42 9.46 0.35 5.61e-20 Pancreatic cancer; BRCA cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -19.0 -0.6 3.8e-64 Chronic sinus infection; BRCA cis rs34779708 0.766 rs35308730 chr10:35549796 C/T cg03585969 chr10:35415529 CREM 0.43 8.71 0.33 2.56e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg23711669 chr6:146136114 FBXO30 -0.76 -17.44 -0.57 5.18e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg25427524 chr10:38739819 LOC399744 0.67 16.32 0.54 2.52e-50 Extrinsic epigenetic age acceleration; BRCA trans rs8062405 0.721 rs151303 chr16:28492510 C/A cg09719594 chr16:21412588 NA -0.35 -7.94 -0.3 8.97e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs877282 0.898 rs11253341 chr10:765008 G/C cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg02544614 chr20:61657117 NA 0.28 7.93 0.3 1.01e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs637571 0.522 rs503524 chr11:65751764 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.47 0.35 5.14e-20 Eosinophil percentage of white cells; BRCA cis rs9393777 0.513 rs6904071 chr6:27047256 G/A cg12292205 chr6:26970375 C6orf41 -0.63 -9.87 -0.36 1.71e-21 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg25554036 chr4:6271136 WFS1 0.42 9.91 0.36 1.24e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs62380364 0.602 rs606393 chr5:88058163 T/C cg22951263 chr5:87985283 NA -0.37 -10.32 -0.38 3.34e-23 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.36 -0.35 1.33e-19 Bipolar disorder; BRCA cis rs700651 0.821 rs770661 chr2:198725444 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.18 0.37 1.21e-22 Intracranial aneurysm; BRCA cis rs3106136 0.527 rs4235050 chr4:95157156 A/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.08 -0.37 2.85e-22 Capecitabine sensitivity; BRCA cis rs897080 0.515 rs698813 chr2:44705615 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.74 0.33 1.99e-17 Height; BRCA cis rs6088765 0.606 rs2425024 chr20:33844938 G/T cg24642439 chr20:33292090 TP53INP2 -0.43 -8.76 -0.33 1.69e-17 Ulcerative colitis; BRCA cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg22974920 chr21:40686053 BRWD1 -0.36 -8.25 -0.31 9.2e-16 Cognitive function; BRCA cis rs7937682 0.632 rs14133 chr11:111782697 C/G cg09085632 chr11:111637200 PPP2R1B 0.76 16.24 0.54 6.46e-50 Primary sclerosing cholangitis; BRCA cis rs36051895 0.632 rs10974993 chr9:5182159 C/T cg02405213 chr9:5042618 JAK2 -0.48 -9.37 -0.35 1.22e-19 Pediatric autoimmune diseases; BRCA cis rs12348691 0.503 rs10983975 chr9:100614188 A/C cg13688889 chr9:100608707 NA -0.49 -9.92 -0.37 1.14e-21 Alopecia areata; BRCA cis rs7493 1.000 rs2299263 chr7:95040411 A/G cg01874867 chr7:94954059 PON1 0.38 7.88 0.3 1.37e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6546886 0.912 rs6745792 chr2:74284033 G/A cg14702570 chr2:74259524 NA -0.32 -8.02 -0.3 4.98e-15 Dialysis-related mortality; BRCA cis rs11971779 0.680 rs7795520 chr7:139079207 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.25e-18 Motion sickness; BRCA cis rs10465746 0.967 rs6576956 chr1:84343885 T/G cg10977910 chr1:84465055 TTLL7 0.51 10.28 0.38 4.89e-23 Obesity-related traits; BRCA cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA trans rs7615952 0.611 rs9681518 chr3:125615130 A/G cg07211511 chr3:129823064 LOC729375 -0.96 -13.62 -0.47 2.72e-37 Blood pressure (smoking interaction); BRCA cis rs7582180 0.629 rs11688285 chr2:100948054 A/C cg14675211 chr2:100938903 LONRF2 0.53 12.03 0.43 3.34e-30 Intelligence (multi-trait analysis); BRCA cis rs6426558 0.537 rs12039370 chr1:227326472 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -9.3 -0.35 2.13e-19 Neutrophil percentage of white cells; BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg21782813 chr7:2030301 MAD1L1 0.42 12.01 0.43 4.21e-30 Bipolar disorder and schizophrenia; BRCA cis rs3784262 0.528 rs1994926 chr15:58334587 C/T cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.22 -0.37 8.02e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4919694 1.000 rs80327774 chr10:104656671 T/C cg04362960 chr10:104952993 NT5C2 0.95 14.84 0.51 5.3e-43 Arsenic metabolism; BRCA cis rs2832191 0.655 rs2247110 chr21:30323888 G/A cg08807101 chr21:30365312 RNF160 -0.76 -19.72 -0.62 5.84e-68 Dental caries; BRCA cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg15017067 chr4:17643749 FAM184B 0.31 9.7 0.36 7.64e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9790314 0.690 rs1903423 chr3:160842252 A/G cg03342759 chr3:160939853 NMD3 -0.54 -11.39 -0.41 1.79e-27 Morning vs. evening chronotype; BRCA cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg06627628 chr2:24431161 ITSN2 -0.57 -9.08 -0.34 1.29e-18 Lymphocyte counts; BRCA cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg15605315 chr1:45957053 TESK2 -0.46 -9.26 -0.34 2.99e-19 High light scatter reticulocyte count; BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg14004847 chr7:1930337 MAD1L1 -0.5 -10.53 -0.38 5.31e-24 Bipolar disorder and schizophrenia; BRCA cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg22105103 chr4:187893119 NA -0.39 -12.09 -0.43 1.95e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.898 rs113522526 chr2:24018476 C/T cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 6.95e-17 Lymphocyte counts; BRCA cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.27 0.31 7.53e-16 Diabetic retinopathy; BRCA trans rs6598955 0.671 rs11247901 chr1:26612693 T/A cg07461501 chr17:79650226 HGS;ARL16 -0.69 -16.68 -0.55 3.79e-52 Obesity-related traits; BRCA cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs7727544 0.684 rs274560 chr5:131719450 T/C cg07395648 chr5:131743802 NA 0.39 9.67 0.36 9.85e-21 Blood metabolite levels; BRCA cis rs4742903 0.904 rs7028408 chr9:106859811 G/A cg21169611 chr9:106856078 SMC2 0.36 9.32 0.35 1.83e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7944584 0.632 rs11606683 chr11:47302733 C/T cg20307385 chr11:47447363 PSMC3 0.59 11.78 0.42 4.15e-29 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.06 -0.49 2.43e-39 Platelet count; BRCA cis rs711245 0.572 rs3821150 chr2:36795233 G/A cg01206211 chr2:36825736 FEZ2 0.44 10.34 0.38 2.86e-23 Height; BRCA cis rs7666738 0.830 rs34412187 chr4:99010454 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.78 0.39 5.41e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 0.684 rs11072600 chr15:76867915 T/C cg23625390 chr15:77176239 SCAPER -0.54 -13.69 -0.48 1.33e-37 Blood metabolite levels; BRCA cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.93e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13126279 chr21:47581558 C21orf56 0.5 10.83 0.39 3.42e-25 Testicular germ cell tumor; BRCA cis rs9399137 0.507 rs6569986 chr6:135311641 T/C cg22676075 chr6:135203613 NA 0.44 8.62 0.32 5.21e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4728302 0.583 rs58955798 chr7:133158420 C/T cg10665199 chr7:133106180 EXOC4 0.47 10.09 0.37 2.51e-22 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg05234568 chr11:5960015 NA -0.5 -9.94 -0.37 9.5e-22 DNA methylation (variation); BRCA cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg10295955 chr4:187884368 NA -0.86 -24.64 -0.7 1.01e-94 Lobe attachment (rater-scored or self-reported); BRCA cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.48 -10.19 -0.37 1.08e-22 Bipolar disorder; BRCA cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg26116260 chr4:7069785 GRPEL1 0.91 26.37 0.72 3.06e-104 Monocyte percentage of white cells; BRCA cis rs13161895 1.000 rs17079966 chr5:179443190 G/T cg02702477 chr5:179499311 RNF130 0.45 8.59 0.32 6.9e-17 LDL cholesterol; BRCA cis rs1577917 1.000 rs12664335 chr6:86597774 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 12.77 0.45 1.93e-33 Response to antipsychotic treatment; BRCA cis rs478304 1.000 rs478304 chr11:65494260 G/T cg08755490 chr11:65554678 OVOL1 0.5 10.06 0.37 3.44e-22 Acne (severe); BRCA cis rs6429082 0.715 rs2172718 chr1:235580727 A/G cg26050004 chr1:235667680 B3GALNT2 -0.55 -13.78 -0.48 4.97e-38 Adiposity; BRCA cis rs11148252 0.846 rs8001624 chr13:53002995 T/C cg00495681 chr13:53174319 NA 0.41 8.73 0.33 2.22e-17 Lewy body disease; BRCA cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg03452623 chr4:187889614 NA 0.36 11.69 0.42 9.6e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg24060327 chr5:131705240 SLC22A5 -0.5 -10.34 -0.38 2.74e-23 Blood metabolite levels; BRCA cis rs2415984 0.622 rs10147795 chr14:46936528 C/T cg14871534 chr14:47121158 RPL10L -0.33 -8.05 -0.3 3.91e-15 Number of children ever born; BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg21724239 chr8:58056113 NA 0.57 9.3 0.35 2.24e-19 Developmental language disorder (linguistic errors); BRCA cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -8.44 -0.32 2.12e-16 Height; BRCA cis rs312274 0.588 rs12424493 chr12:41299694 A/G cg17827154 chr12:41323612 CNTN1 -0.45 -11.31 -0.41 3.66e-27 Metabolite levels (X-11787); BRCA trans rs2197308 0.765 rs68029712 chr12:37906585 T/G cg06521331 chr12:34319734 NA -0.55 -9.76 -0.36 4.59e-21 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -8.62 -0.32 5.23e-17 Schizophrenia; BRCA cis rs11711311 1.000 rs2242109 chr3:113434100 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.79 -0.36 3.51e-21 IgG glycosylation; BRCA cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg21573476 chr21:45109991 RRP1B -0.35 -9.15 -0.34 7.57e-19 Mean corpuscular volume; BRCA cis rs7267979 0.933 rs1130694 chr20:25276297 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.3 0.35 2.23e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11997175 0.646 rs55898196 chr8:33765862 A/G ch.8.33884649F chr8:33765107 NA 0.43 10.05 0.37 3.83e-22 Body mass index; BRCA cis rs77972916 0.505 rs6736400 chr2:43500804 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.7 -11.88 -0.43 1.47e-29 Granulocyte percentage of myeloid white cells; BRCA cis rs7092929 0.883 rs551307 chr10:3597542 T/C cg14308648 chr10:3568949 NA 0.46 8.48 0.32 1.59e-16 Coronary artery calcification; BRCA cis rs9858542 1.000 rs9836291 chr3:49697459 G/A cg03060546 chr3:49711283 APEH -0.59 -12.08 -0.43 2.06e-30 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9323205 0.871 rs2999393 chr14:51655167 G/T cg23942311 chr14:51606299 NA 0.33 7.8 0.3 2.44e-14 Cancer; BRCA cis rs9359856 0.564 rs41273329 chr6:90393483 G/A cg13799429 chr6:90582589 CASP8AP2 -0.7 -8.77 -0.33 1.67e-17 Bipolar disorder; BRCA cis rs644148 0.738 rs2686767 chr19:44995037 G/C cg15540054 chr19:45004280 ZNF180 -0.4 -8.41 -0.32 2.65e-16 Personality dimensions; BRCA cis rs1401999 0.714 rs1000002 chr3:183635768 A/G cg20387954 chr3:183756860 HTR3D -0.4 -8.96 -0.33 3.42e-18 Anterior chamber depth; BRCA cis rs2066819 1.000 rs76430365 chr12:56699993 A/C cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs17376456 0.877 rs10063045 chr5:93457584 A/T cg25358565 chr5:93447407 FAM172A 1.25 17.59 0.57 8.68e-57 Diabetic retinopathy; BRCA cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg17211192 chr8:82754475 SNX16 0.64 12.03 0.43 3.56e-30 Diastolic blood pressure; BRCA trans rs1973993 0.561 rs3862909 chr1:96987091 T/G cg10631902 chr5:14652156 NA -0.41 -10.15 -0.37 1.56e-22 Weight; BRCA cis rs11098499 0.863 rs9997631 chr4:120469995 C/G cg09307838 chr4:120376055 NA 0.7 14.91 0.51 2.39e-43 Corneal astigmatism; BRCA cis rs600806 0.813 rs6664236 chr1:109986672 C/A cg20591472 chr1:110008990 SYPL2 0.33 8.25 0.31 9.23e-16 Intelligence (multi-trait analysis); BRCA cis rs1011018 0.628 rs10224408 chr7:139415723 G/A cg03224163 chr7:139420300 HIPK2 -0.54 -8.84 -0.33 9.06e-18 Systolic blood pressure; BRCA cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.17 0.56 1.26e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.0 0.34 2.59e-18 Motion sickness; BRCA cis rs34779708 0.733 rs12249814 chr10:35542757 T/C cg03585969 chr10:35415529 CREM 0.45 9.18 0.34 5.96e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -18.18 -0.58 7.95e-60 Initial pursuit acceleration; BRCA trans rs853679 0.546 rs2232423 chr6:28366151 A/G cg01620082 chr3:125678407 NA -0.97 -11.01 -0.4 6.21e-26 Depression; BRCA cis rs523522 0.962 rs10849753 chr12:120910813 C/T cg27279351 chr12:120934652 DYNLL1 0.57 13.5 0.47 1.05e-36 High light scatter reticulocyte count; BRCA cis rs35995292 0.500 rs8180877 chr7:38931258 G/A cg19327137 chr7:38886074 VPS41 0.38 12.63 0.45 8.59e-33 Subjective well-being (multi-trait analysis); BRCA cis rs9868809 0.505 rs9811027 chr3:48725014 G/C cg00383909 chr3:49044727 WDR6 0.59 10.59 0.39 2.88e-24 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg14844989 chr11:31128820 NA 0.46 9.91 0.36 1.27e-21 Red blood cell count; BRCA cis rs17401966 0.965 rs12751375 chr1:10291874 C/G cg03954927 chr1:10346856 KIF1B 0.45 12.9 0.45 5.47e-34 Hepatocellular carcinoma; BRCA cis rs561341 1.000 rs527256 chr17:30321293 C/G cg00745463 chr17:30367425 LRRC37B -0.54 -8.89 -0.33 6.17e-18 Hip circumference adjusted for BMI; BRCA cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg18446336 chr7:2847575 GNA12 -0.4 -9.94 -0.37 9.34e-22 Height; BRCA cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg00071950 chr4:10020882 SLC2A9 0.66 16.74 0.55 1.91e-52 Bone mineral density; BRCA cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg12386194 chr3:101231763 SENP7 0.46 9.65 0.36 1.12e-20 Colorectal cancer; BRCA cis rs2075371 0.932 rs1862048 chr7:133978167 C/G cg20476274 chr7:133979776 SLC35B4 -0.55 -13.19 -0.46 2.54e-35 Mean platelet volume; BRCA cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg20701182 chr2:24300061 SF3B14 0.66 9.54 0.35 3.02e-20 Lymphocyte counts; BRCA cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg06115741 chr20:33292138 TP53INP2 0.49 10.99 0.4 7.55e-26 Coronary artery disease; BRCA cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11890956 chr21:40555474 PSMG1 0.96 24.35 0.69 3.62e-93 Cognitive function; BRCA cis rs6121246 0.909 rs6060960 chr20:30394517 G/T cg13852791 chr20:30311386 BCL2L1 -0.83 -16.35 -0.54 1.85e-50 Mean corpuscular hemoglobin; BRCA cis rs10876993 0.890 rs1689597 chr12:58051886 G/A cg18357645 chr12:58087776 OS9 0.44 12.43 0.44 6.32e-32 Celiac disease or Rheumatoid arthritis; BRCA cis rs4689592 0.513 rs4689586 chr4:7067413 A/G cg02503808 chr4:7069936 GRPEL1 0.8 18.49 0.59 1.73e-61 Monocyte percentage of white cells; BRCA cis rs6750795 0.507 rs1667320 chr2:232418314 G/T cg19187155 chr2:232395269 NMUR1 0.69 17.23 0.56 6.33e-55 Height; BRCA cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.62 -12.83 -0.45 1.04e-33 Monocyte percentage of white cells; BRCA cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg09699651 chr6:150184138 LRP11 0.38 8.8 0.33 1.32e-17 Testicular germ cell tumor; BRCA trans rs208520 0.690 rs2126120 chr6:66742754 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.79 0.64 1.05e-73 Exhaled nitric oxide output; BRCA cis rs34779708 0.931 rs13376871 chr10:35369056 A/G cg03585969 chr10:35415529 CREM 0.49 10.33 0.38 3.17e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7193541 0.691 rs3851728 chr16:74480660 C/T cg01733217 chr16:74700730 RFWD3 0.61 16.01 0.54 9e-49 Multiple myeloma; BRCA cis rs4888262 0.545 rs12716768 chr16:74556486 A/G cg01733217 chr16:74700730 RFWD3 -0.68 -17.49 -0.57 2.84e-56 Testicular germ cell tumor; BRCA cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg18016565 chr1:150552671 MCL1 0.35 7.99 0.3 6.13e-15 Melanoma; BRCA cis rs10896135 0.526 rs624561 chr11:66414915 C/T cg24851651 chr11:66362959 CCS -0.45 -9.07 -0.34 1.4e-18 Bipolar disorder; BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg22800045 chr5:56110881 MAP3K1 0.71 13.19 0.46 2.57e-35 Initial pursuit acceleration; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg11833968 chr6:79620685 NA -0.42 -9.3 -0.35 2.27e-19 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.749 rs45458197 chr14:56145018 A/T cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs6582630 0.638 rs11182428 chr12:38526387 T/C cg26384229 chr12:38710491 ALG10B -0.46 -10.66 -0.39 1.51e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs925228 0.504 rs6755030 chr2:24318343 C/T cg20701182 chr2:24300061 SF3B14 -0.52 -8.52 -0.32 1.13e-16 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs921968 0.541 rs687747 chr2:219399627 T/C cg10223061 chr2:219282414 VIL1 -0.27 -8.12 -0.31 2.37e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs765787 0.530 rs11636410 chr15:45535913 A/C cg25801113 chr15:45476975 SHF -0.32 -8.06 -0.3 3.75e-15 Uric acid levels; BRCA cis rs72781680 0.821 rs56064672 chr2:24156769 G/T cg08917208 chr2:24149416 ATAD2B 0.64 10.69 0.39 1.17e-24 Lymphocyte counts; BRCA cis rs2066819 1.000 rs77032009 chr12:56679971 A/G cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA trans rs6582630 0.555 rs10785443 chr12:38463792 A/C cg06521331 chr12:34319734 NA -0.42 -7.93 -0.3 9.54e-15 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.61 -0.32 5.56e-17 Aortic root size; BRCA cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg09658497 chr7:2847517 GNA12 -0.41 -8.58 -0.32 6.93e-17 Height; BRCA cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg24692254 chr21:30365293 RNF160 -0.46 -10.84 -0.39 2.95e-25 Dental caries; BRCA cis rs870825 0.616 rs35533356 chr4:185639134 A/G cg04058563 chr4:185651563 MLF1IP 0.76 16.85 0.55 5.72e-53 Blood protein levels; BRCA trans rs35110281 0.805 rs2838319 chr21:44991901 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.49 0.32 1.44e-16 Mean corpuscular volume; BRCA cis rs12348691 0.503 rs3021523 chr9:100616583 T/C cg13688889 chr9:100608707 NA -0.49 -9.9 -0.36 1.32e-21 Alopecia areata; BRCA cis rs8180040 0.966 rs7651762 chr3:47470484 G/A cg16586182 chr3:47516702 SCAP 0.65 15.17 0.51 1.27e-44 Colorectal cancer; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.67 0.61 1.03e-67 Alzheimer's disease; BRCA cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.98 0.37 6.93e-22 Bipolar disorder; BRCA cis rs8017423 0.647 rs4904679 chr14:90821801 C/T cg04374321 chr14:90722782 PSMC1 -0.49 -11.96 -0.43 6.75e-30 Mortality in heart failure; BRCA cis rs11792861 0.926 rs72607173 chr9:111879398 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.27 0.31 7.86e-16 Menarche (age at onset); BRCA cis rs9814567 0.806 rs4519744 chr3:134321523 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs73001065 0.636 rs8182472 chr19:19539891 A/G cg03709012 chr19:19516395 GATAD2A 0.98 14.06 0.49 2.65e-39 LDL cholesterol; BRCA cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA trans rs4596713 0.508 rs59620993 chr9:71771911 C/T cg16512924 chr15:28394682 HERC2 0.45 10.66 0.39 1.52e-24 Headache; BRCA cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg27286337 chr10:134555280 INPP5A 0.8 13.17 0.46 3.21e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3857536 0.673 rs7759888 chr6:66891922 T/C cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs881375 0.967 rs7046108 chr9:123660339 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.51 -10.65 -0.39 1.65e-24 Rheumatoid arthritis; BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 21.71 0.65 1.08e-78 Platelet count; BRCA cis rs4891159 0.790 rs17059379 chr18:74160316 A/T cg24786174 chr18:74118243 ZNF516 0.75 17.73 0.57 1.77e-57 Longevity; BRCA cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.18 -0.43 7.78e-31 Bipolar disorder; BRCA trans rs9858542 0.953 rs6766581 chr3:49539401 T/C cg21659725 chr3:3221576 CRBN -0.47 -9.99 -0.37 6.33e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs558133 1.000 rs506500 chr5:78414337 C/T cg25119155 chr5:78426943 BHMT -0.47 -10.72 -0.39 9.15e-25 Blood and toenail selenium levels; BRCA cis rs6433895 0.601 rs13033038 chr2:182052555 C/T cg00481216 chr2:181971175 NA 0.41 7.87 0.3 1.51e-14 Lymphocyte counts; BRCA cis rs6700896 0.931 rs11208717 chr1:66158994 T/C cg04111102 chr1:66153794 NA 0.34 8.5 0.32 1.3e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs10788264 0.652 rs9633732 chr10:124056473 G/T cg09507567 chr10:124027408 NA 0.4 8.24 0.31 9.5e-16 Total body bone mineral density; BRCA cis rs67460515 1.000 rs67460515 chr3:161068566 T/C cg04691961 chr3:161091175 C3orf57 -0.39 -8.82 -0.33 1.06e-17 Parkinson's disease; BRCA cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 12.78 0.45 1.83e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs1475390 chr1:46816340 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs4242434 0.854 rs3064 chr8:22451688 C/G cg03733263 chr8:22462867 KIAA1967 -0.89 -21.1 -0.64 2.01e-75 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs6121246 0.909 rs7354225 chr20:30296881 C/T cg13852791 chr20:30311386 BCL2L1 0.75 12.17 0.43 8.98e-31 Mean corpuscular hemoglobin; BRCA cis rs939658 0.776 rs35382567 chr15:79440897 C/T cg17916960 chr15:79447300 NA -0.43 -10.98 -0.4 8.11e-26 Refractive error; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.84 -0.33 9.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1400816 0.850 rs1878583 chr2:172725301 C/T cg13550731 chr2:172543902 DYNC1I2 0.51 7.92 0.3 1.04e-14 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg14789911 chr21:47582049 C21orf56 -0.38 -8.07 -0.3 3.61e-15 Testicular germ cell tumor; BRCA cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg01256987 chr12:42539512 GXYLT1 -0.57 -11.71 -0.42 7.85e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1506636 0.962 rs17623873 chr7:123417100 C/A cg03229431 chr7:123269106 ASB15 0.63 12.87 0.45 7.59e-34 Plateletcrit;Platelet count; BRCA cis rs6912958 0.712 rs4706294 chr6:88317675 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.51 -0.32 1.23e-16 Monocyte percentage of white cells; BRCA cis rs652260 1.000 rs604938 chr19:7903484 A/G cg26014689 chr19:7917955 EVI5L 0.52 12.15 0.43 1.02e-30 Menarche (age at onset); BRCA cis rs2282802 0.685 rs2337081 chr5:139642414 A/C cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.12e-15 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11890956 chr21:40555474 PSMG1 -0.81 -19.7 -0.61 7.23e-68 Cognitive function; BRCA cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg24531977 chr5:56204891 C5orf35 -0.72 -15.87 -0.53 4.38e-48 Initial pursuit acceleration; BRCA cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.62 0.39 2.18e-24 Bipolar disorder; BRCA cis rs7580658 0.963 rs6732279 chr2:128089540 G/T cg09760422 chr2:128146352 NA -0.35 -7.85 -0.3 1.71e-14 Protein C levels; BRCA cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg21017887 chr14:105400489 NA 0.66 17.48 0.57 3.47e-56 Rheumatoid arthritis; BRCA cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.77 10.41 0.38 1.48e-23 Initial pursuit acceleration; BRCA cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.67 0.39 1.41e-24 Bipolar disorder; BRCA cis rs490234 0.841 rs521119 chr9:128314394 T/C cg14078157 chr9:128172775 NA 0.34 8.11 0.31 2.66e-15 Mean arterial pressure; BRCA cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg02187348 chr16:89574699 SPG7 -0.35 -8.39 -0.32 3.07e-16 Multiple myeloma (IgH translocation); BRCA cis rs7927771 0.832 rs56030824 chr11:47397353 G/A cg18512352 chr11:47633146 NA -0.34 -7.99 -0.3 6.27e-15 Subjective well-being; BRCA cis rs35110281 0.720 rs162374 chr21:44927089 T/C cg21573476 chr21:45109991 RRP1B 0.37 9.29 0.34 2.44e-19 Mean corpuscular volume; BRCA cis rs1577917 0.740 rs9353320 chr6:86244848 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 12.93 0.46 3.95e-34 Response to antipsychotic treatment; BRCA cis rs72627123 0.867 rs77320708 chr14:74478482 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.66 7.93 0.3 9.93e-15 Morning vs. evening chronotype; BRCA cis rs7103648 1.000 rs10838709 chr11:47447346 C/T cg20307385 chr11:47447363 PSMC3 0.89 27.11 0.73 2.41e-108 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9309711 0.736 rs28619526 chr2:3496804 T/C cg10845886 chr2:3471009 TTC15 -0.64 -13.18 -0.46 2.87e-35 Neurofibrillary tangles; BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg08888203 chr3:10149979 C3orf24 0.67 14.07 0.49 2.42e-39 Alzheimer's disease; BRCA cis rs10992471 0.535 rs10117041 chr9:95282331 A/G cg14631576 chr9:95140430 CENPP -0.35 -8.37 -0.31 3.71e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs875971 0.862 rs778707 chr7:65857027 G/A cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs1401999 0.714 rs1533683 chr3:183635488 C/T cg20387954 chr3:183756860 HTR3D 0.38 8.8 0.33 1.29e-17 Anterior chamber depth; BRCA cis rs7246967 0.673 rs2112610 chr19:22916851 C/T cg23217946 chr19:22817039 ZNF492 0.49 9.0 0.34 2.48e-18 Bronchopulmonary dysplasia; BRCA cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -10.04 -0.37 3.99e-22 Mean corpuscular volume; BRCA cis rs2115630 1.000 rs6496452 chr15:85372645 A/T cg12863693 chr15:85201151 NMB -0.35 -8.43 -0.32 2.27e-16 P wave terminal force; BRCA cis rs4595586 0.545 rs6580894 chr12:39371951 A/G cg26384229 chr12:38710491 ALG10B 0.41 9.13 0.34 8.88e-19 Morning vs. evening chronotype; BRCA cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg00684032 chr4:1343700 KIAA1530 0.33 8.42 0.32 2.55e-16 Obesity-related traits; BRCA cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg27489772 chr12:121021490 NA 0.45 8.02 0.3 5.07e-15 Type 1 diabetes nephropathy; BRCA cis rs634534 0.622 rs1192168 chr11:65730945 T/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.36 8.73 0.33 2.2e-17 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs6545883 0.862 rs1880866 chr2:61698972 G/C cg15711740 chr2:61764176 XPO1 -0.52 -13.2 -0.46 2.42e-35 Tuberculosis; BRCA cis rs113835537 0.502 rs7104378 chr11:66216675 A/G cg24851651 chr11:66362959 CCS 0.41 7.99 0.3 6.24e-15 Airway imaging phenotypes; BRCA cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11890956 chr21:40555474 PSMG1 -0.84 -21.45 -0.65 2.87e-77 Cognitive function; BRCA cis rs67460515 0.892 rs1382429 chr3:161015153 T/C cg03342759 chr3:160939853 NMD3 -0.8 -17.63 -0.57 5.28e-57 Parkinson's disease; BRCA cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg05084668 chr3:125655381 ALG1L -0.47 -8.12 -0.31 2.43e-15 Blood pressure (smoking interaction); BRCA cis rs6445967 1.000 rs14927 chr3:58305033 G/T cg23715586 chr3:58305044 RPP14 -0.34 -8.55 -0.32 9.09e-17 Platelet count; BRCA cis rs7737355 0.947 rs31584 chr5:130993124 A/G cg06307176 chr5:131281290 NA 0.53 10.39 0.38 1.87e-23 Life satisfaction; BRCA cis rs889312 0.500 rs252905 chr5:56118875 C/T cg24531977 chr5:56204891 C5orf35 -0.41 -8.53 -0.32 1.03e-16 Breast cancer;Breast cancer (early onset); BRCA trans rs2262909 0.853 rs56207853 chr19:22292357 C/T cg17074339 chr11:11642133 GALNTL4 0.44 8.55 0.32 9.34e-17 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg08213375 chr14:104286397 PPP1R13B 0.58 15.19 0.52 1e-44 Schizophrenia; BRCA cis rs2637266 1.000 rs7098929 chr10:78361194 T/G cg18941641 chr10:78392320 NA 0.35 7.84 0.3 1.83e-14 Pulmonary function; BRCA cis rs11997175 0.624 rs6996590 chr8:33680486 A/G ch.8.33884649F chr8:33765107 NA 0.4 9.27 0.34 2.82e-19 Body mass index; BRCA cis rs6142102 0.961 rs973409 chr20:32536364 A/G cg24642439 chr20:33292090 TP53INP2 0.44 8.07 0.3 3.57e-15 Skin pigmentation; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.5 -0.59 1.6e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2408955 0.522 rs2051851 chr12:48485940 G/C cg24011408 chr12:48396354 COL2A1 -0.39 -7.83 -0.3 2.07e-14 Glycated hemoglobin levels; BRCA cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.48 0.32 1.51e-16 Diabetic retinopathy; BRCA cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.12 -0.46 5.39e-35 Chronic sinus infection; BRCA cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg25319279 chr11:5960081 NA -0.39 -7.95 -0.3 8.58e-15 DNA methylation (variation); BRCA cis rs881375 0.967 rs10733648 chr9:123700779 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 10.66 0.39 1.55e-24 Rheumatoid arthritis; BRCA cis rs11958404 0.932 rs72816563 chr5:157427447 C/T cg05962755 chr5:157440814 NA 0.54 10.24 0.38 7.1e-23 IgG glycosylation; BRCA cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg14530993 chr4:882597 GAK 0.59 9.68 0.36 8.77e-21 Intelligence (multi-trait analysis); BRCA cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg02297831 chr4:17616191 MED28 0.34 7.86 0.3 1.64e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs870825 0.860 rs2705886 chr4:185608591 T/C cg04058563 chr4:185651563 MLF1IP -0.66 -11.65 -0.42 1.44e-28 Blood protein levels; BRCA cis rs7481584 0.624 rs511990 chr11:3052936 A/G cg08508325 chr11:3079039 CARS 0.28 8.43 0.32 2.22e-16 Calcium levels; BRCA cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg12573674 chr2:1569213 NA -0.64 -14.48 -0.5 2.8e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg04025307 chr7:1156635 C7orf50 0.71 18.43 0.59 3.62e-61 Longevity;Endometriosis; BRCA cis rs11792861 0.816 rs11790105 chr9:111731785 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.22 0.31 1.11e-15 Menarche (age at onset); BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg22535103 chr8:58192502 C8orf71 -0.46 -8.2 -0.31 1.31e-15 Developmental language disorder (linguistic errors); BRCA cis rs9462027 0.675 rs9296132 chr6:34777531 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.89 -0.3 1.33e-14 Systemic lupus erythematosus; BRCA cis rs875971 0.895 rs778700 chr7:65866450 C/T cg11764359 chr7:65958608 NA 0.81 19.65 0.61 1.26e-67 Aortic root size; BRCA cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg17063962 chr7:91808500 NA 0.56 12.65 0.45 7.2e-33 Breast cancer; BRCA cis rs924607 1.000 rs12523022 chr5:598643 C/T cg04476341 chr5:669733 TPPP -0.38 -10.33 -0.38 3.01e-23 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg26031613 chr14:104095156 KLC1 -0.55 -9.38 -0.35 1.1e-19 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs4722166 0.532 rs1404008 chr7:22756000 A/T cg05472934 chr7:22766657 IL6 0.44 11.04 0.4 4.52e-26 Lung cancer; BRCA cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg24549020 chr5:56110836 MAP3K1 0.58 11.73 0.42 6.76e-29 Initial pursuit acceleration; BRCA cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.57 -0.45 1.62e-32 Developmental language disorder (linguistic errors); BRCA cis rs73036520 0.560 rs346750 chr19:45737218 G/T cg01416317 chr19:45737208 EXOC3L2 -0.51 -11.7 -0.42 8.28e-29 Monocyte percentage of white cells; BRCA cis rs889312 0.500 rs252903 chr5:56117952 A/G cg24531977 chr5:56204891 C5orf35 -0.43 -8.98 -0.33 2.97e-18 Breast cancer;Breast cancer (early onset); BRCA trans rs3942852 0.955 rs1910364 chr11:48113232 A/G cg15704280 chr7:45808275 SEPT13 -0.47 -8.38 -0.31 3.49e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs7819412 0.691 rs73198970 chr8:11040216 T/C cg21775007 chr8:11205619 TDH -0.5 -10.34 -0.38 2.77e-23 Triglycerides; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26314531 chr2:26401878 FAM59B -0.63 -10.77 -0.39 5.9e-25 Gut microbiome composition (summer); BRCA trans rs11098499 0.731 rs10015579 chr4:120271802 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.62 0.39 2.18e-24 Corneal astigmatism; BRCA cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg11764359 chr7:65958608 NA 0.66 12.0 0.43 4.83e-30 Aortic root size; BRCA trans rs11098499 0.954 rs59394118 chr4:120295551 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.71e-15 Corneal astigmatism; BRCA cis rs9831754 0.906 rs9869812 chr3:78385679 G/A cg06138941 chr3:78371609 NA -0.76 -16.6 -0.55 9.62e-52 Calcium levels; BRCA cis rs3784262 0.654 rs4646568 chr15:58344290 A/G cg12031962 chr15:58353849 ALDH1A2 0.5 13.06 0.46 1.04e-34 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9287719 0.967 rs7587114 chr2:10739963 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg01483505 chr11:975446 AP2A2 0.33 9.07 0.34 1.44e-18 Alzheimer's disease (late onset); BRCA cis rs2066819 1.000 rs76430365 chr12:56699993 A/C cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg03929089 chr4:120376271 NA 0.71 14.75 0.5 1.37e-42 Coronary artery disease; BRCA cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg00409905 chr10:38381863 ZNF37A -0.49 -10.42 -0.38 1.34e-23 Extrinsic epigenetic age acceleration; BRCA cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg21475434 chr5:93447410 FAM172A 0.69 8.49 0.32 1.43e-16 Diabetic retinopathy; BRCA cis rs4642101 0.686 rs9822382 chr3:12828828 T/G cg24848339 chr3:12840334 CAND2 0.43 11.4 0.41 1.5e-27 QRS complex (12-leadsum); BRCA cis rs4689388 0.890 rs4481292 chr4:6298375 C/T cg25554036 chr4:6271136 WFS1 0.37 8.83 0.33 1.01e-17 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg21545522 chr1:205238299 TMCC2 0.4 8.34 0.31 4.62e-16 Mean corpuscular volume;Mean platelet volume; BRCA trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg26384229 chr12:38710491 ALG10B 0.74 16.31 0.54 2.84e-50 Morning vs. evening chronotype; BRCA cis rs9612 0.950 rs7256472 chr19:44246970 C/T cg08581076 chr19:44259116 C19orf61 0.52 8.99 0.34 2.75e-18 Exhaled nitric oxide output; BRCA cis rs243505 1.000 rs243510 chr7:148432534 A/G cg09806900 chr7:148480153 CUL1 -0.44 -8.86 -0.33 8.14e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg08888203 chr3:10149979 C3orf24 0.67 14.27 0.49 2.74e-40 Alzheimer's disease; BRCA cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg12386194 chr3:101231763 SENP7 -0.7 -12.78 -0.45 1.85e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs10911232 0.507 rs10797820 chr1:183011366 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 16.92 0.56 2.52e-53 Hypertriglyceridemia; BRCA cis rs4423214 0.879 rs10898144 chr11:71151540 A/T cg05163923 chr11:71159392 DHCR7 -0.56 -11.8 -0.42 3.4e-29 Vitamin D levels; BRCA trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg22491629 chr6:157744540 C6orf35 -0.67 -12.4 -0.44 8.87e-32 Hemostatic factors and hematological phenotypes; BRCA cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -12.19 -0.43 7.03e-31 Schizophrenia; BRCA cis rs8062405 1.000 rs8062405 chr16:28837906 C/T cg09754948 chr16:28834200 ATXN2L -0.46 -9.12 -0.34 9.95e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg03433033 chr1:76189801 ACADM -0.88 -27.75 -0.74 7.61e-112 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs921968 0.541 rs7601872 chr2:219319885 C/G cg02176678 chr2:219576539 TTLL4 -0.54 -13.72 -0.48 9.6e-38 Mean corpuscular hemoglobin concentration; BRCA cis rs2625529 0.652 rs8030815 chr15:72403001 T/C cg16672083 chr15:72433130 SENP8 0.64 15.42 0.52 8.08e-46 Red blood cell count; BRCA cis rs4423214 0.802 rs4402322 chr11:71184015 C/G cg05163923 chr11:71159392 DHCR7 -0.56 -11.35 -0.41 2.58e-27 Vitamin D levels; BRCA trans rs11098499 0.863 rs6853998 chr4:120475860 C/A cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg16230307 chr14:35515116 FAM177A1 0.76 15.24 0.52 6.03e-45 Psoriasis; BRCA cis rs9435341 0.965 rs2335104 chr1:107583641 A/T cg09367891 chr1:107599246 PRMT6 0.41 7.99 0.3 6.15e-15 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs4595586 0.505 rs12827467 chr12:39374014 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg23711669 chr6:146136114 FBXO30 0.71 16.82 0.55 7.67e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs17376456 0.741 rs12374432 chr5:93481348 C/A cg25358565 chr5:93447407 FAM172A 1.19 19.37 0.61 4.15e-66 Diabetic retinopathy; BRCA cis rs9790314 1.000 rs336543 chr3:161061080 C/T cg04691961 chr3:161091175 C3orf57 0.59 14.33 0.49 1.45e-40 Morning vs. evening chronotype; BRCA cis rs10129255 0.500 rs11628999 chr14:107208446 C/T cg07958169 chr14:107095056 NA -0.39 -8.45 -0.32 1.95e-16 Kawasaki disease; BRCA trans rs11098499 0.754 rs10006259 chr4:120242145 C/T cg25214090 chr10:38739885 LOC399744 0.44 10.27 0.38 5.09e-23 Corneal astigmatism; BRCA cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.62 0.55 8.5e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.03e-18 Height; BRCA cis rs367943 0.966 rs348924 chr5:112817930 T/G cg12552261 chr5:112820674 MCC -0.55 -12.1 -0.43 1.7e-30 Type 2 diabetes; BRCA cis rs367943 1.000 rs348925 chr5:112817533 T/A cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs12618769 0.625 rs3769709 chr2:99187433 A/T cg10123293 chr2:99228465 UNC50 0.44 8.67 0.32 3.42e-17 Bipolar disorder; BRCA cis rs4588572 0.686 rs67689570 chr5:77676843 T/C cg11547950 chr5:77652471 NA 0.44 7.83 0.3 2.01e-14 Triglycerides; BRCA cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg20503657 chr10:835505 NA 1.3 21.64 0.65 2.49e-78 Eosinophil percentage of granulocytes; BRCA cis rs708547 1.000 rs708547 chr4:57821309 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.5 -8.59 -0.32 6.59e-17 Response to bleomycin (chromatid breaks); BRCA cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg06238570 chr21:40685208 BRWD1 -0.42 -8.45 -0.32 1.95e-16 Cognitive function; BRCA cis rs4689388 0.926 rs1801214 chr4:6303022 C/T cg25554036 chr4:6271136 WFS1 0.42 9.8 0.36 3.29e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4363385 0.818 rs946095 chr1:153006470 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.49 -0.32 1.4e-16 Inflammatory skin disease; BRCA cis rs727479 0.543 rs56097510 chr15:51533478 C/G cg19946085 chr15:51559439 CYP19A1 -0.28 -7.85 -0.3 1.72e-14 Estradiol levels; BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg27170947 chr2:26402098 FAM59B 0.73 12.26 0.44 3.34e-31 Gut microbiome composition (summer); BRCA cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.52 10.06 0.37 3.27e-22 Lung cancer in ever smokers; BRCA cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg24130564 chr14:104152367 KLC1 -0.34 -7.92 -0.3 1.09e-14 Body mass index; BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg22920501 chr2:26401640 FAM59B -0.65 -11.27 -0.41 5.41e-27 Gut microbiome composition (summer); BRCA cis rs1577917 0.959 rs12201739 chr6:86720739 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -12.89 -0.45 6.01e-34 Response to antipsychotic treatment; BRCA cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -13.56 -0.47 5.11e-37 Personality dimensions; BRCA trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg13010199 chr12:38710504 ALG10B 0.49 9.63 0.36 1.35e-20 Morning vs. evening chronotype; BRCA cis rs701145 0.585 rs1727940 chr3:153827257 C/G cg12800244 chr3:153838788 SGEF 0.61 7.81 0.3 2.3e-14 Coronary artery disease; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg12444411 chr7:2802554 GNA12 -0.33 -8.29 -0.31 6.49e-16 Height; BRCA trans rs561341 1.000 rs554078 chr17:30330109 A/C cg20587970 chr11:113659929 NA -1.35 -24.74 -0.7 2.87e-95 Hip circumference adjusted for BMI; BRCA trans rs3857536 0.813 rs7771716 chr6:66946769 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg03146154 chr1:46216737 IPP -0.47 -9.99 -0.37 6.14e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9796 0.621 rs1659228 chr15:41471978 A/G cg18705301 chr15:41695430 NDUFAF1 -0.37 -7.94 -0.3 9.04e-15 Menopause (age at onset); BRCA cis rs7246657 0.722 rs35863684 chr19:38109777 C/T cg14683738 chr19:37701593 ZNF585B 0.46 8.01 0.3 5.5e-15 Coronary artery calcification; BRCA cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg06212747 chr3:49208901 KLHDC8B 0.48 9.71 0.36 6.69e-21 Parkinson's disease; BRCA cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.32 -0.35 1.91e-19 Menopause (age at onset); BRCA cis rs9649465 1.000 rs9641715 chr7:123348623 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.33 -0.31 5.11e-16 Migraine; BRCA cis rs3733346 0.553 rs2290403 chr4:942006 G/A cg20916646 chr4:852691 GAK 0.41 9.77 0.36 4.1e-21 Sjögren's syndrome; BRCA cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg11057378 chr10:81107060 PPIF 0.36 8.74 0.33 1.97e-17 Height; BRCA trans rs11039798 0.778 rs7944523 chr11:48911019 G/A cg15704280 chr7:45808275 SEPT13 0.6 8.89 0.33 6.42e-18 Axial length; BRCA cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg01283332 chr5:1856932 NA -0.35 -8.71 -0.33 2.64e-17 Cardiovascular disease risk factors; BRCA cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs2880765 0.835 rs11633604 chr15:86031579 T/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.61 -0.32 5.47e-17 Coronary artery disease; BRCA cis rs4363385 0.720 rs6704498 chr1:152964740 C/A cg21543102 chr1:152974771 SPRR3 -0.3 -8.64 -0.32 4.48e-17 Inflammatory skin disease; BRCA cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg09877947 chr5:131593287 PDLIM4 0.35 8.59 0.32 6.55e-17 Blood metabolite levels; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9318086 0.904 rs9580769 chr13:24439724 T/C cg25267304 chr13:24462978 PCOTH;MIPEP -0.29 -8.42 -0.32 2.52e-16 Myopia (pathological); BRCA cis rs67981189 0.656 rs2810113 chr14:71395770 C/T cg15816911 chr14:71606274 NA -0.35 -8.09 -0.3 3e-15 Schizophrenia; BRCA cis rs4076764 0.958 rs11590567 chr1:163396438 A/G cg24596788 chr1:163392923 NA -0.4 -10.74 -0.39 7.26e-25 Motion sickness; BRCA cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.56 9.34 0.35 1.6e-19 Renal function-related traits (BUN); BRCA cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg25358565 chr5:93447407 FAM172A 1.08 17.55 0.57 1.38e-56 Diabetic retinopathy; BRCA cis rs2073499 1.000 rs3806708 chr3:50306249 T/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.6 8.31 0.31 5.91e-16 Schizophrenia; BRCA cis rs9837602 1.000 rs9864437 chr3:99764754 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.16 0.4 1.5e-26 Breast cancer; BRCA cis rs7258465 0.965 rs7256534 chr19:18586791 C/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.47 -0.32 1.66e-16 Breast cancer; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg23358479 chr7:1110784 C7orf50 -0.47 -7.99 -0.3 6.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs910316 0.687 rs175059 chr14:75490667 T/C cg08847533 chr14:75593920 NEK9 -0.83 -20.59 -0.63 1.18e-72 Height; BRCA cis rs9868809 0.881 rs3806694 chr3:48672334 G/C cg00383909 chr3:49044727 WDR6 0.56 8.43 0.32 2.28e-16 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs12618769 0.597 rs3729568 chr2:99100196 T/G cg10123293 chr2:99228465 UNC50 0.41 8.52 0.32 1.14e-16 Bipolar disorder; BRCA cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg15839431 chr19:19639596 YJEFN3 0.36 8.21 0.31 1.19e-15 Bipolar disorder; BRCA cis rs7246657 0.943 rs13345116 chr19:37847098 A/T cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.39e-16 Colorectal cancer; BRCA cis rs1953600 0.870 rs2573356 chr10:81949363 C/T cg04850286 chr10:81895943 PLAC9 0.32 9.0 0.34 2.57e-18 Sarcoidosis; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg23708337 chr7:1209742 NA 0.55 11.79 0.42 3.73e-29 Longevity;Endometriosis; BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg26314531 chr2:26401878 FAM59B -0.79 -12.55 -0.44 1.89e-32 Gut microbiome composition (summer); BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg02951883 chr7:2050386 MAD1L1 -0.57 -14.68 -0.5 3.04e-42 Bipolar disorder and schizophrenia; BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg14004847 chr7:1930337 MAD1L1 0.42 8.06 0.3 3.63e-15 Bipolar disorder and schizophrenia; BRCA cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.6 0.74 5.62e-111 Chronic sinus infection; BRCA cis rs938554 0.513 rs10939650 chr4:9998440 C/T cg00071950 chr4:10020882 SLC2A9 0.42 8.92 0.33 4.73e-18 Blood metabolite levels; BRCA cis rs3125734 0.653 rs1007976 chr10:63970144 C/T cg19640130 chr10:64028056 RTKN2 0.31 8.96 0.33 3.45e-18 Rheumatoid arthritis; BRCA cis rs7246967 0.673 rs3844578 chr19:22880610 G/C cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg17366294 chr4:99064904 C4orf37 0.41 9.48 0.35 4.76e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs9287719 0.967 rs2010080 chr2:10736552 A/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs3956705 0.762 rs13311608 chr7:32999601 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.44 -8.62 -0.32 5.16e-17 Red cell distribution width; BRCA cis rs812925 0.519 rs2463099 chr2:61618311 T/C cg15711740 chr2:61764176 XPO1 0.33 8.31 0.31 5.88e-16 Immature fraction of reticulocytes; BRCA cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg04315214 chr1:2043799 PRKCZ -0.47 -12.48 -0.44 3.93e-32 Height; BRCA cis rs6570726 0.526 rs9376934 chr6:145738702 A/G cg23711669 chr6:146136114 FBXO30 0.47 10.11 0.37 2.17e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.28 0.34 2.63e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs523522 0.962 rs670568 chr12:121021206 C/T cg27279351 chr12:120934652 DYNLL1 0.56 13.41 0.47 2.63e-36 High light scatter reticulocyte count; BRCA cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg25019033 chr10:957182 NA -0.41 -7.89 -0.3 1.33e-14 Eosinophil percentage of granulocytes; BRCA cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.17 0.37 1.23e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs367943 1.000 rs348962 chr5:112819086 C/T cg12552261 chr5:112820674 MCC 0.55 12.1 0.43 1.68e-30 Type 2 diabetes; BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.31e-16 Total body bone mineral density; BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.36 -0.44 1.25e-31 Lymphocyte counts; BRCA cis rs11779988 0.545 rs411531 chr8:17795934 A/G cg01800426 chr8:17659068 MTUS1 -0.4 -8.11 -0.31 2.58e-15 Breast cancer; BRCA cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.66 -14.85 -0.51 4.54e-43 Hip circumference adjusted for BMI; BRCA cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg09184832 chr6:79620586 NA 0.51 11.52 0.41 4.97e-28 Intelligence (multi-trait analysis); BRCA cis rs72615157 0.628 rs7801070 chr7:99847147 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.66 11.48 0.41 7.03e-28 Lung function (FEV1/FVC); BRCA cis rs6840360 0.571 rs72728182 chr4:152487027 T/C cg22705602 chr4:152727874 NA -0.32 -7.84 -0.3 1.88e-14 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.909 rs6060644 chr20:30265652 G/A cg13852791 chr20:30311386 BCL2L1 0.86 16.75 0.55 1.82e-52 Mean corpuscular hemoglobin; BRCA cis rs7582180 0.585 rs6736311 chr2:100950599 C/G cg14675211 chr2:100938903 LONRF2 0.44 10.11 0.37 2.18e-22 Intelligence (multi-trait analysis); BRCA cis rs6684514 1.000 rs12117903 chr1:156311165 G/T cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs4803468 0.935 rs12602 chr19:41889748 T/C cg09537434 chr19:41945824 ATP5SL -0.97 -21.8 -0.65 3.57e-79 Height; BRCA cis rs3857067 0.806 rs17302467 chr4:95112056 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg03433033 chr1:76189801 ACADM -0.75 -16.95 -0.56 1.64e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2425143 1.000 rs73902908 chr20:34365112 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.2 -0.34 5.11e-19 Blood protein levels; BRCA cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg01884057 chr2:25150051 NA 0.35 9.41 0.35 9e-20 Body mass index; BRCA cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg13319975 chr6:146136371 FBXO30 -0.43 -10.1 -0.37 2.46e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.45 8.04 0.3 4.45e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs950776 0.518 rs55690619 chr15:78833612 A/G cg22563815 chr15:78856949 CHRNA5 -0.35 -8.39 -0.31 3.18e-16 Sudden cardiac arrest; BRCA cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg22535103 chr8:58192502 C8orf71 -0.42 -8.76 -0.33 1.72e-17 Developmental language disorder (linguistic errors); BRCA cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.01 0.56 8.73e-54 Morning vs. evening chronotype; BRCA cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg11657440 chr19:46296263 DMWD -0.56 -13.37 -0.47 4.15e-36 Coronary artery disease; BRCA cis rs3818285 0.679 rs612155 chr10:111630731 C/G cg00817464 chr10:111662876 XPNPEP1 0.44 14.21 0.49 4.82e-40 Superior crus of antihelix expression; BRCA trans rs11098499 1.000 rs28419773 chr4:120211061 T/C cg25214090 chr10:38739885 LOC399744 0.5 10.94 0.4 1.2e-25 Corneal astigmatism; BRCA cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg13770153 chr20:60521292 NA -0.46 -11.04 -0.4 4.75e-26 Body mass index; BRCA cis rs41005 1.000 rs193931 chr2:8107435 A/G cg03155496 chr2:8117019 LOC339788 -0.57 -15.25 -0.52 5.22e-45 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs1043763 0.826 rs4758689 chr12:122611004 A/T cg14400030 chr12:122498111 BCL7A -0.62 -13.76 -0.48 6.7e-38 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs10754283 0.967 rs10922685 chr1:90118320 A/G cg21401794 chr1:90099060 LRRC8C 0.48 11.71 0.42 7.68e-29 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.88 0.43 1.45e-29 Personality dimensions; BRCA cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg10495392 chr1:46806563 NSUN4 -0.43 -8.06 -0.3 3.74e-15 Menopause (age at onset); BRCA cis rs10489202 0.608 rs16828093 chr1:168078384 C/T cg24449463 chr1:168025552 DCAF6 -0.46 -15.32 -0.52 2.28e-45 Schizophrenia; BRCA cis rs17270561 0.609 rs1892248 chr6:25768914 C/T cg16482183 chr6:26056742 HIST1H1C 0.48 9.62 0.36 1.54e-20 Iron status biomarkers; BRCA cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg11764359 chr7:65958608 NA -0.75 -16.48 -0.55 4.02e-51 Aortic root size; BRCA cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs700651 0.624 rs12105927 chr2:198937258 G/A cg00792783 chr2:198669748 PLCL1 0.38 8.29 0.31 6.61e-16 Intracranial aneurysm; BRCA cis rs858239 0.539 rs28624974 chr7:23188936 T/C cg23682824 chr7:23144976 KLHL7 0.42 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.33 0.31 4.97e-16 Cognitive ability; BRCA cis rs10740039 0.804 rs894383 chr10:62443117 A/G cg02922035 chr10:62493342 NA 0.41 7.83 0.3 1.98e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs17685 0.671 rs60303271 chr7:75760008 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.58 0.35 2.04e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs6933660 0.512 rs13198669 chr6:151799924 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.59 -10.32 -0.38 3.49e-23 Menarche (age at onset); BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg13880726 chr7:1868755 MAD1L1 0.41 8.11 0.31 2.69e-15 Bipolar disorder and schizophrenia; BRCA cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -8.63 -0.32 4.85e-17 Schizophrenia; BRCA cis rs561341 1.000 rs548957 chr17:30302411 G/A cg00745463 chr17:30367425 LRRC37B -0.53 -8.87 -0.33 7.27e-18 Hip circumference adjusted for BMI; BRCA cis rs7528419 0.927 rs660240 chr1:109817838 T/C cg00908766 chr1:109817496 CELSR2 0.62 18.08 0.58 2.45e-59 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; BRCA cis rs523522 0.962 rs7488320 chr12:120981630 G/T cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.22e-27 High light scatter reticulocyte count; BRCA trans rs208520 0.690 rs1351867 chr6:66760995 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 21.05 0.64 4.24e-75 Exhaled nitric oxide output; BRCA cis rs4363385 0.747 rs1415962 chr1:152958731 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.44 -0.35 7e-20 Inflammatory skin disease; BRCA cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg24675658 chr1:53192096 ZYG11B 0.63 15.23 0.52 6.76e-45 Monocyte count; BRCA cis rs4285028 0.747 rs3772126 chr3:121354583 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.82 -15.59 -0.52 1.13e-46 Multiple sclerosis; BRCA cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg01579765 chr21:45077557 HSF2BP -0.4 -10.76 -0.39 6.05e-25 Mean corpuscular volume; BRCA cis rs67460515 0.596 rs35589595 chr3:160930984 G/A cg17135325 chr3:160939158 NMD3 0.45 8.58 0.32 7.26e-17 Parkinson's disease; BRCA cis rs1994135 0.654 rs1447872 chr12:33718343 C/A cg06521331 chr12:34319734 NA -0.55 -9.36 -0.35 1.36e-19 Resting heart rate; BRCA cis rs3767633 0.748 rs6667896 chr1:161837407 G/A cg09175582 chr1:161736000 ATF6 0.52 8.39 0.32 3.09e-16 IgG glycosylation; BRCA trans rs11098499 0.863 rs7678400 chr4:120461957 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.2 0.43 6.68e-31 Corneal astigmatism; BRCA trans rs11098499 0.954 rs17005535 chr4:120411562 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.95 -0.3 8.25e-15 Corneal astigmatism; BRCA cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.98 -0.51 1.01e-43 Total cholesterol levels; BRCA cis rs1008375 0.931 rs10939734 chr4:17570709 C/T cg15017067 chr4:17643749 FAM184B 0.35 10.59 0.39 2.91e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2996428 0.667 rs7511793 chr1:3744249 A/G cg17848003 chr1:3704513 LRRC47 0.24 7.86 0.3 1.61e-14 Red cell distribution width; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.15 0.31 1.87e-15 Tonsillectomy; BRCA cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg05347473 chr6:146136440 FBXO30 0.42 8.48 0.32 1.57e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs3824867 0.959 rs4237544 chr11:47454271 G/T cg20307385 chr11:47447363 PSMC3 -0.52 -11.59 -0.42 2.56e-28 Mean corpuscular hemoglobin; BRCA cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg17063962 chr7:91808500 NA 0.53 12.47 0.44 4.19e-32 Breast cancer; BRCA cis rs2997447 0.655 rs55820521 chr1:26374286 C/T cg19633962 chr1:26362018 EXTL1 -0.69 -11.43 -0.41 1.2100000000000001e-27 QRS complex (12-leadsum); BRCA cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg09065629 chr16:1709722 CRAMP1L 0.37 8.57 0.32 7.54e-17 Coronary artery disease; BRCA cis rs2016266 0.859 rs56225815 chr12:53740090 C/G cg26875137 chr12:53738046 NA -0.44 -9.67 -0.36 9.75e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA trans rs11098499 0.863 rs2127823 chr4:120485670 G/T cg25214090 chr10:38739885 LOC399744 0.51 11.51 0.41 5.53e-28 Corneal astigmatism; BRCA cis rs7123876 0.587 rs11602616 chr11:72364077 T/C cg03713592 chr11:72463424 ARAP1 0.65 9.98 0.37 6.94e-22 Body mass index; BRCA cis rs6450176 0.625 rs67656636 chr5:53288455 C/A ch.5.1024479R chr5:53302184 ARL15 -0.67 -15.05 -0.51 4.97e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9649465 0.967 rs3757505 chr7:123391641 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.13 -0.31 2.21e-15 Migraine; BRCA trans rs75804782 0.521 rs56373856 chr2:239437926 C/T cg01134436 chr17:81009848 B3GNTL1 0.66 8.59 0.32 6.84e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs1030877 0.515 rs2679893 chr2:105909554 A/G cg02079111 chr2:105885981 TGFBRAP1 0.62 11.97 0.43 6.3e-30 Obesity-related traits; BRCA cis rs243505 0.867 rs243526 chr7:148417073 C/T cg09806900 chr7:148480153 CUL1 -0.39 -8.16 -0.31 1.84e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg05729581 chr11:3078854 CARS -0.35 -8.69 -0.32 3.11e-17 Longevity; BRCA cis rs11785693 0.866 rs11782170 chr8:4976942 A/G cg26367366 chr8:4980734 NA -0.57 -9.88 -0.36 1.63e-21 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs9818758 0.607 rs11552724 chr3:49156473 C/G cg00383909 chr3:49044727 WDR6 0.98 15.61 0.53 9.41e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7824557 0.767 rs28507159 chr8:11166076 C/T cg21775007 chr8:11205619 TDH 0.61 11.8 0.42 3.3e-29 Retinal vascular caliber; BRCA cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 9.21 0.34 4.74e-19 Mean platelet volume; BRCA cis rs7953508 0.506 rs10859532 chr12:93960917 G/C cg18151635 chr12:93972918 NA -0.47 -9.28 -0.34 2.68e-19 Pubertal anthropometrics; BRCA cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg18876405 chr7:65276391 NA 0.58 14.46 0.5 3.36e-41 Aortic root size; BRCA cis rs7474896 0.583 rs4934898 chr10:37990395 G/C cg25427524 chr10:38739819 LOC399744 -0.55 -9.93 -0.37 1.09e-21 Obesity (extreme); BRCA cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg02012338 chr4:187126139 CYP4V2 0.86 9.59 0.35 1.86e-20 Blood protein levels; BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.3 -0.44 2.46e-31 Alzheimer's disease; BRCA cis rs4588572 0.643 rs1159929 chr5:77768820 A/G cg11547950 chr5:77652471 NA 0.47 8.45 0.32 2.01e-16 Triglycerides; BRCA cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg12311346 chr5:56204834 C5orf35 -0.81 -16.7 -0.55 3.32e-52 Initial pursuit acceleration; BRCA cis rs589448 0.933 rs2249093 chr12:69753512 G/C cg14784868 chr12:69753453 YEATS4 0.79 25.23 0.71 5.18e-98 Cerebrospinal fluid biomarker levels; BRCA cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.86e-24 Motion sickness; BRCA cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg18252515 chr7:66147081 NA -0.55 -11.03 -0.4 4.99e-26 Corneal structure; BRCA cis rs10463316 0.894 rs4099170 chr5:150766583 G/A cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.17e-16 Metabolite levels (Pyroglutamine); BRCA cis rs10789491 1.000 rs2083485 chr1:47170091 G/C cg15501359 chr1:47185051 KIAA0494 0.65 18.2 0.58 5.93e-60 Response to hepatitis C treatment; BRCA cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg03433033 chr1:76189801 ACADM 0.86 22.18 0.66 2.75e-81 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs13046373 0.535 rs7281767 chr21:32022062 T/C cg16812893 chr21:31813075 KRTAP15-1 0.37 9.28 0.34 2.58e-19 HDL cholesterol; BRCA cis rs6426558 0.537 rs12139758 chr1:227260519 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 9.36 0.35 1.33e-19 Neutrophil percentage of white cells; BRCA cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg26647111 chr11:31128758 NA 0.44 9.66 0.36 1.07e-20 Red blood cell count; BRCA cis rs3820928 0.934 rs16822890 chr2:227761477 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.36 -0.31 3.79e-16 Pulmonary function; BRCA cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg05283184 chr6:79620031 NA -0.35 -7.95 -0.3 8.28e-15 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.545 rs7973338 chr12:39380704 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs10992471 0.756 rs11792342 chr9:95143668 G/A cg14631576 chr9:95140430 CENPP -0.37 -8.99 -0.34 2.71e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs990171 0.506 rs6543107 chr2:102750730 A/T cg22835712 chr2:102737379 NA 0.59 11.26 0.41 6.15e-27 Lymphocyte counts; BRCA cis rs739401 0.572 rs389285 chr11:3062673 G/A cg08508325 chr11:3079039 CARS -0.45 -16.07 -0.54 4.92e-49 Longevity; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs12618769 0.597 rs3754893 chr2:99063149 T/A cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA cis rs6459788 0.693 rs35146559 chr7:157238557 G/A cg06271696 chr7:157225062 NA -0.37 -9.73 -0.36 5.9e-21 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs4478858 0.735 rs1566963 chr1:31772206 G/A cg00250761 chr1:31883323 NA -0.32 -8.31 -0.31 5.91e-16 Alcohol dependence; BRCA cis rs10876993 0.821 rs1629032 chr12:58038686 C/T cg18357645 chr12:58087776 OS9 0.43 12.02 0.43 3.75e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg02353165 chr6:42928485 GNMT 0.78 18.88 0.6 1.69e-63 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg02297831 chr4:17616191 MED28 0.34 7.98 0.3 6.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7824557 0.701 rs2060465 chr8:11162609 T/C cg15556689 chr8:8085844 FLJ10661 0.37 8.83 0.33 1.02e-17 Retinal vascular caliber; BRCA cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg12386194 chr3:101231763 SENP7 0.46 9.79 0.36 3.64e-21 Colorectal cancer; BRCA cis rs7973719 0.769 rs61917956 chr12:7348659 T/C cg07052231 chr12:7363540 PEX5 0.35 7.9 0.3 1.23e-14 IgG glycosylation; BRCA cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03264133 chr6:25882463 NA -0.55 -11.36 -0.41 2.29e-27 Intelligence (multi-trait analysis); BRCA cis rs3793683 0.825 rs3793674 chr10:134555773 C/T cg27286337 chr10:134555280 INPP5A -0.84 -20.47 -0.63 5.46e-72 Migraine; BRCA cis rs6665290 0.901 rs12410103 chr1:227197408 T/C cg10327440 chr1:227177885 CDC42BPA -1.16 -48.97 -0.89 1.81e-218 Myeloid white cell count; BRCA cis rs7408868 1.000 rs1548554 chr19:15277938 C/T cg14696996 chr19:15285081 NOTCH3 1.01 14.77 0.5 1.08e-42 Pulse pressure; BRCA cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg24549020 chr5:56110836 MAP3K1 0.67 13.55 0.47 6.1e-37 Initial pursuit acceleration; BRCA cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg03060546 chr3:49711283 APEH 0.6 10.31 0.38 3.56e-23 Menarche (age at onset); BRCA cis rs10267417 0.603 rs12668717 chr7:19932912 G/T cg05791153 chr7:19748676 TWISTNB 0.43 8.09 0.3 3.01e-15 Night sleep phenotypes; BRCA cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg06784218 chr1:46089804 CCDC17 -0.42 -9.75 -0.36 5.15e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs561341 1.000 rs757009 chr17:30243937 A/G cg23018236 chr17:30244563 NA -0.49 -9.09 -0.34 1.2e-18 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg01475377 chr6:109611718 NA -0.59 -16.43 -0.54 7.68e-51 Reticulocyte fraction of red cells; BRCA cis rs72781680 0.611 rs72797810 chr2:24336469 G/A cg06627628 chr2:24431161 ITSN2 -0.5 -8.26 -0.31 8.39e-16 Lymphocyte counts; BRCA cis rs4363385 0.818 rs454993 chr1:153008992 C/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg09184832 chr6:79620586 NA -0.43 -8.45 -0.32 2.03e-16 Intelligence (multi-trait analysis); BRCA cis rs992157 0.710 rs10167446 chr2:219056866 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.47 10.54 0.38 4.85e-24 Colorectal cancer; BRCA cis rs9309473 0.948 rs13392691 chr2:73748980 G/A cg20560298 chr2:73613845 ALMS1 -0.47 -11.63 -0.42 1.75e-28 Metabolite levels; BRCA cis rs7412746 0.658 rs4537557 chr1:150734436 A/G cg15448220 chr1:150897856 SETDB1 0.36 8.26 0.31 8.31e-16 Melanoma; BRCA cis rs61931739 0.534 rs1705757 chr12:34091637 A/G cg06521331 chr12:34319734 NA -0.63 -12.5 -0.44 3.27e-32 Morning vs. evening chronotype; BRCA cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg13906792 chr15:75199810 C15orf17 -0.39 -9.05 -0.34 1.73e-18 Breast cancer; BRCA trans rs2739330 0.587 rs4820571 chr22:24242973 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.33 -8.69 -0.33 2.98e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs561341 1.000 rs501957 chr17:30314504 C/T cg00745463 chr17:30367425 LRRC37B -0.49 -8.44 -0.32 2.09e-16 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg17366294 chr4:99064904 C4orf37 0.53 11.38 0.41 1.85e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg05347473 chr6:146136440 FBXO30 -0.41 -8.27 -0.31 7.6e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg23583168 chr7:148888333 NA -0.82 -18.74 -0.6 9.08e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7408868 0.831 rs1548555 chr19:15278057 A/G cg14696996 chr19:15285081 NOTCH3 1.01 14.77 0.5 1.08e-42 Pulse pressure; BRCA cis rs13102973 0.965 rs4597893 chr4:135863043 C/T cg14419869 chr4:135874104 NA -0.59 -12.91 -0.45 4.85e-34 Subjective well-being; BRCA cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.42 -8.36 -0.31 4e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.576 rs58702363 chr11:31246397 C/A cg14844989 chr11:31128820 NA -0.44 -9.8 -0.36 3.24e-21 Red blood cell count; BRCA cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs829883 0.659 rs11109517 chr12:98921574 A/C cg25150519 chr12:98850993 NA 0.49 9.01 0.34 2.36e-18 Colorectal adenoma (advanced); BRCA cis rs10267417 0.535 rs6960731 chr7:19869379 C/G cg05791153 chr7:19748676 TWISTNB -0.49 -9.55 -0.35 2.61e-20 Night sleep phenotypes; BRCA cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg06697600 chr4:7070879 GRPEL1 -0.53 -10.8 -0.39 4.4e-25 Monocyte percentage of white cells; BRCA cis rs10489202 1.000 rs10489202 chr1:167903079 A/C cg24449463 chr1:168025552 DCAF6 0.42 11.04 0.4 4.51e-26 Schizophrenia; BRCA cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg22105103 chr4:187893119 NA -0.39 -12.83 -0.45 1.06e-33 Lobe attachment (rater-scored or self-reported); BRCA cis rs897080 0.515 rs786405 chr2:44710367 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.42 0.35 8.41e-20 Height; BRCA cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA trans rs35110281 0.659 rs11909064 chr21:45092095 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.33 0.31 5.09e-16 Mean corpuscular volume; BRCA cis rs8031584 0.958 rs34294266 chr15:31246840 A/G cg14829155 chr15:31115871 NA -0.43 -9.69 -0.36 8.15e-21 Huntington's disease progression; BRCA cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21659725 chr3:3221576 CRBN -0.47 -11.94 -0.43 8.58e-30 Intelligence (multi-trait analysis); BRCA cis rs6138458 1.000 rs2387361 chr20:24899905 C/T cg26195577 chr20:24973756 C20orf3 -0.98 -24.65 -0.7 8.06e-95 Blood protein levels; BRCA cis rs11583043 0.958 rs12746722 chr1:101464789 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.39 7.82 0.3 2.23e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg08601574 chr20:25228251 PYGB -0.39 -8.95 -0.33 3.74e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13118159 0.801 rs10024996 chr4:1328297 G/A cg05025164 chr4:1340916 KIAA1530 0.36 7.86 0.3 1.68e-14 Longevity; BRCA cis rs67478160 0.595 rs12879501 chr14:104272634 G/T cg08213375 chr14:104286397 PPP1R13B 0.66 18.66 0.59 2.4e-62 Schizophrenia; BRCA cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg21573476 chr21:45109991 RRP1B -0.37 -9.31 -0.35 1.97e-19 Mean corpuscular volume; BRCA cis rs7395581 0.918 rs3816725 chr11:47305669 T/G cg25783544 chr11:47291846 MADD 0.43 9.6 0.36 1.71e-20 HDL cholesterol; BRCA cis rs9527 0.590 rs1541213 chr10:104885330 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs138880 0.505 rs56248708 chr22:50306969 G/A cg22709217 chr22:50311962 ALG12;CRELD2 -0.58 -8.71 -0.33 2.67e-17 Schizophrenia; BRCA cis rs477895 0.568 rs12418035 chr11:63871558 G/A cg23719950 chr11:63933701 MACROD1 -0.52 -8.76 -0.33 1.8e-17 Mean platelet volume; BRCA cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg16339924 chr4:17578868 LAP3 0.59 14.37 0.49 8.75e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.53 0.47 7.03e-37 Platelet count; BRCA cis rs801193 0.660 rs2659914 chr7:66156914 C/T cg12463550 chr7:65579703 CRCP 0.38 8.11 0.31 2.54e-15 Aortic root size; BRCA cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs7772486 0.840 rs2777478 chr6:146309117 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.59 -0.32 6.86e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs9462027 0.628 rs4601124 chr6:34776910 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.84 -0.3 1.96e-14 Systemic lupus erythematosus; BRCA cis rs6815814 0.851 rs11466617 chr4:38780471 T/C cg02016764 chr4:38805732 TLR1 -0.5 -7.82 -0.3 2.17e-14 Breast cancer; BRCA trans rs11039798 0.920 rs11500574 chr11:48713986 A/T cg15704280 chr7:45808275 SEPT13 0.59 8.76 0.33 1.72e-17 Axial length; BRCA cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg25801113 chr15:45476975 SHF -0.34 -8.33 -0.31 4.76e-16 Uric acid levels; BRCA cis rs7177699 0.525 rs56076311 chr15:79115120 A/G cg00540400 chr15:79124168 NA -0.28 -8.0 -0.3 5.94e-15 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs735396 0.731 rs1182933 chr12:121454622 C/T cg02403541 chr12:121454288 C12orf43 0.67 12.72 0.45 3.34e-33 N-glycan levels; BRCA cis rs11920090 0.858 rs12633935 chr3:170674865 A/C cg09710316 chr3:170744871 SLC2A2 0.49 8.31 0.31 5.56e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs6545883 0.894 rs4672431 chr2:61519922 C/A cg15711740 chr2:61764176 XPO1 0.49 12.12 0.43 1.38e-30 Tuberculosis; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg18402987 chr7:1209562 NA 0.47 9.85 0.36 2.05e-21 Longevity;Endometriosis; BRCA cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.48 -8.16 -0.31 1.72e-15 Schizophrenia; BRCA trans rs11098499 0.554 rs2175381 chr4:120265967 T/C cg25214090 chr10:38739885 LOC399744 0.43 9.99 0.37 6.03e-22 Corneal astigmatism; BRCA trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg23505145 chr19:12996616 KLF1 0.53 12.08 0.43 2.01e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg10523679 chr1:76189770 ACADM -0.46 -8.09 -0.3 3.08e-15 Daytime sleep phenotypes; BRCA cis rs4664304 0.620 rs1039932 chr2:160712772 G/A cg01092293 chr2:160761427 LY75 0.35 8.28 0.31 7.19e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg04267008 chr7:1944627 MAD1L1 -0.65 -13.73 -0.48 8.95e-38 Bipolar disorder and schizophrenia; BRCA cis rs9814567 0.896 rs7642266 chr3:134346025 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.38 -0.31 3.41e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg20203395 chr5:56204925 C5orf35 -0.43 -9.66 -0.36 1.04e-20 Initial pursuit acceleration; BRCA cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg09184832 chr6:79620586 NA -0.51 -11.3 -0.41 3.86e-27 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs11935078 chr4:99010476 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.43 0.57 6.11e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg04511125 chr2:88470314 THNSL2 0.95 13.67 0.48 1.76e-37 Plasma clusterin levels; BRCA cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg24060327 chr5:131705240 SLC22A5 -0.64 -12.48 -0.44 3.78e-32 Breast cancer; BRCA cis rs7737355 0.947 rs32110 chr5:131045835 T/C cg06307176 chr5:131281290 NA 0.52 10.16 0.37 1.45e-22 Life satisfaction; BRCA cis rs17685 0.712 rs6976236 chr7:75741087 G/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.64 -0.36 1.3e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs67460515 0.926 rs13062740 chr3:161024208 G/A cg03342759 chr3:160939853 NMD3 -0.8 -17.64 -0.57 5.09e-57 Parkinson's disease; BRCA trans rs6479891 1.000 rs2719815 chr10:65210294 G/C cg14819942 chr15:35414228 NA 0.35 8.55 0.32 9.19e-17 Arthritis (juvenile idiopathic); BRCA cis rs10845606 1.000 rs10845605 chr12:12833468 T/C cg09462578 chr12:12878428 APOLD1 -0.61 -10.85 -0.39 2.65e-25 Systemic lupus erythematosus; BRCA cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.67 -0.32 3.67e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.93 0.4 1.36e-25 Rheumatoid arthritis; BRCA cis rs7248779 0.512 rs7250002 chr19:2413188 A/G cg22729335 chr19:2427816 TIMM13 1.01 25.49 0.71 2.1e-99 Cortisol levels (saliva); BRCA cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg04455712 chr21:45112962 RRP1B 0.38 9.82 0.36 2.74e-21 Mean corpuscular volume; BRCA trans rs208520 0.690 rs10944872 chr6:66708239 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.93 19.78 0.62 2.75e-68 Exhaled nitric oxide output; BRCA cis rs2404602 0.735 rs56246286 chr15:76690731 C/T cg23625390 chr15:77176239 SCAPER -0.52 -12.59 -0.45 1.32e-32 Blood metabolite levels; BRCA cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg03477792 chr4:77819574 ANKRD56 0.66 16.15 0.54 1.8e-49 Emphysema distribution in smoking; BRCA cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 7.84 0.3 1.9e-14 Electroencephalogram traits; BRCA cis rs11785693 0.862 rs11781233 chr8:4993653 C/G cg26367366 chr8:4980734 NA -0.64 -11.01 -0.4 6.4e-26 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs796364 0.755 rs203762 chr2:200905136 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs9486719 0.843 rs2472875 chr6:96844691 G/A cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg10518543 chr12:38710700 ALG10B 0.36 7.92 0.3 1.03e-14 Morning vs. evening chronotype; BRCA cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg27366882 chr3:133540807 NA 0.32 7.95 0.3 8.43e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs1691799 0.799 rs10784525 chr12:66772766 G/A cg16791601 chr12:66731901 HELB -0.58 -15.14 -0.51 1.75e-44 White blood cell count (basophil); BRCA cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg05985134 chr18:33552581 C18orf21 0.64 12.21 0.43 5.7e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.28e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2070488 0.662 rs6599203 chr3:38487802 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 12.6 0.45 1.17e-32 Electrocardiographic conduction measures; BRCA cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg18132916 chr6:79620363 NA -0.46 -10.5 -0.38 6.89e-24 Intelligence (multi-trait analysis); BRCA trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.68 -0.48 1.51e-37 Extrinsic epigenetic age acceleration; BRCA cis rs11098499 0.661 rs10015965 chr4:120268237 A/G cg09307838 chr4:120376055 NA 0.59 12.9 0.45 5.45e-34 Corneal astigmatism; BRCA cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.41 0.38 1.45e-23 Bladder cancer; BRCA cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg08213375 chr14:104286397 PPP1R13B 0.63 17.42 0.57 6.31e-56 Schizophrenia; BRCA cis rs826838 1.000 rs826889 chr12:39101076 G/A cg13010199 chr12:38710504 ALG10B -0.43 -10.04 -0.37 4.1e-22 Heart rate; BRCA cis rs7973719 0.773 rs6486911 chr12:7356494 G/C cg07052231 chr12:7363540 PEX5 0.36 8.17 0.31 1.63e-15 IgG glycosylation; BRCA cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg06618935 chr21:46677482 NA -0.36 -8.04 -0.3 4.32e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg07636037 chr3:49044803 WDR6 0.98 28.73 0.75 3.58e-117 Parkinson's disease; BRCA cis rs72627509 1.000 rs57265257 chr4:57839280 A/T cg26694713 chr4:57773883 REST 0.45 8.35 0.31 4.26e-16 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs3617 0.573 rs4687680 chr3:52907372 G/A cg11645453 chr3:52864694 ITIH4 0.34 8.51 0.32 1.27e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs9811920 0.965 rs9837131 chr3:99854514 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.52 12.45 0.44 4.99e-32 Axial length; BRCA cis rs10911232 0.507 rs35782443 chr1:183051502 A/C ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.71e-54 Hypertriglyceridemia; BRCA trans rs4714291 0.802 rs2983140 chr6:40017224 A/G cg02267698 chr19:7991119 CTXN1 -0.46 -9.41 -0.35 9.16e-20 Strep throat; BRCA cis rs13256369 1.000 rs873063 chr8:8572447 A/G cg00074818 chr8:8560427 CLDN23 0.38 8.29 0.31 6.87e-16 Obesity-related traits; BRCA cis rs13102973 0.899 rs17496 chr4:135900227 C/T cg14419869 chr4:135874104 NA -0.53 -10.84 -0.39 2.93e-25 Subjective well-being; BRCA cis rs910316 0.737 rs175080 chr14:75513828 G/A cg23033748 chr14:75592666 NEK9 -0.36 -8.46 -0.32 1.84e-16 Height; BRCA cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg21573476 chr21:45109991 RRP1B -0.33 -8.3 -0.31 6.15e-16 Mean corpuscular volume; BRCA cis rs1030877 0.515 rs2576736 chr2:105890971 C/T cg02079111 chr2:105885981 TGFBRAP1 0.64 12.01 0.43 4.33e-30 Obesity-related traits; BRCA cis rs8114671 0.869 rs1544047 chr20:33670753 T/C cg07148914 chr20:33460835 GGT7 -0.42 -9.11 -0.34 1.09e-18 Height; BRCA cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg13256891 chr4:100009986 ADH5 -0.53 -10.01 -0.37 5.33e-22 Alcohol dependence; BRCA cis rs796364 0.789 rs176008 chr2:200814720 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.8 13.46 0.47 1.5e-36 Schizophrenia; BRCA cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.72 -0.36 6.56e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7020830 0.931 rs7027473 chr9:37132462 A/G cg14294708 chr9:37120828 ZCCHC7 1.19 43.18 0.86 1.27e-191 Schizophrenia; BRCA cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 2.0500000000000001e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12478296 1.000 rs12478296 chr2:243048760 A/G cg18898632 chr2:242989856 NA 0.46 8.25 0.31 8.95e-16 Obesity-related traits; BRCA cis rs17818399 0.533 rs13420857 chr2:46798005 C/G cg02822958 chr2:46747628 ATP6V1E2 -0.51 -10.62 -0.39 2.18e-24 Height; BRCA trans rs35110281 0.548 rs7276316 chr21:45029333 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 9.93 0.37 1.07e-21 Mean corpuscular volume; BRCA cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.95 0.3 8.6e-15 Depression; BRCA cis rs9325144 0.560 rs10506127 chr12:39126686 C/G cg13010199 chr12:38710504 ALG10B -0.34 -7.91 -0.3 1.16e-14 Morning vs. evening chronotype; BRCA cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg08859206 chr1:53392774 SCP2 -0.51 -11.23 -0.41 7.8e-27 Monocyte count; BRCA cis rs4713118 0.786 rs200503 chr6:27785882 A/G cg20933634 chr6:27740509 NA 0.44 8.34 0.31 4.63e-16 Parkinson's disease; BRCA trans rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.01e-14 Endometrial cancer; BRCA cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.63 -0.36 1.34e-20 Alzheimer's disease (late onset); BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg03709012 chr19:19516395 GATAD2A 0.72 15.68 0.53 4.14e-47 Tonsillectomy; BRCA cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg05347473 chr6:146136440 FBXO30 0.45 8.95 0.33 3.74e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs1030877 0.515 rs2576742 chr2:105898822 A/T cg02079111 chr2:105885981 TGFBRAP1 0.65 12.47 0.44 4.41e-32 Obesity-related traits; BRCA cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.77 0.55 1.44e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs68170813 0.559 rs78064065 chr7:106967440 G/A cg02696742 chr7:106810147 HBP1 -0.56 -8.74 -0.33 2.07e-17 Coronary artery disease; BRCA cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg08213375 chr14:104286397 PPP1R13B 0.63 18.06 0.58 3.25e-59 Schizophrenia; BRCA cis rs4363385 0.747 rs9919276 chr1:152968654 A/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.69 -0.33 2.92e-17 Inflammatory skin disease; BRCA cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs9325144 0.647 rs61937754 chr12:39060543 T/C cg26384229 chr12:38710491 ALG10B -0.48 -11.1 -0.4 2.57e-26 Morning vs. evening chronotype; BRCA cis rs17401966 0.800 rs2039778 chr1:10354601 A/G cg03954927 chr1:10346856 KIF1B 0.43 13.7 0.48 1.16e-37 Hepatocellular carcinoma; BRCA cis rs2625529 0.762 rs1384007 chr15:72229534 T/C cg16672083 chr15:72433130 SENP8 -0.84 -17.33 -0.57 2.03e-55 Red blood cell count; BRCA cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.02 -0.43 3.8e-30 Electroencephalogram traits; BRCA cis rs7408868 1.000 rs7250232 chr19:15277199 C/T cg14696996 chr19:15285081 NOTCH3 0.89 12.8 0.45 1.47e-33 Pulse pressure; BRCA cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg01475735 chr3:40494733 NA 0.46 9.42 0.35 8.04e-20 Renal cell carcinoma; BRCA cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg07930552 chr6:133119739 C6orf192 0.8 11.15 0.4 1.61e-26 Type 2 diabetes nephropathy; BRCA cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg24531977 chr5:56204891 C5orf35 0.71 15.44 0.52 6.37e-46 Initial pursuit acceleration; BRCA cis rs919433 1.000 rs7422899 chr2:198163527 G/C cg00792783 chr2:198669748 PLCL1 -0.37 -7.87 -0.3 1.55e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg23029597 chr12:123009494 RSRC2 -0.56 -11.21 -0.41 9.39e-27 Body mass index; BRCA cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg13010199 chr12:38710504 ALG10B 0.52 10.5 0.38 6.6e-24 Heart rate; BRCA cis rs2288073 0.965 rs10173173 chr2:24415461 G/T cg26838691 chr2:24397539 C2orf84 0.47 8.6 0.32 5.94e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg13047869 chr3:10149882 C3orf24 0.57 12.42 0.44 6.69e-32 Alzheimer's disease; BRCA trans rs7647973 0.626 rs9830730 chr3:49675875 G/C cg21659725 chr3:3221576 CRBN -0.47 -8.44 -0.32 2.17e-16 Menarche (age at onset); BRCA cis rs6594499 0.500 rs12514810 chr5:110455357 T/A cg04022379 chr5:110408740 TSLP 0.42 9.09 0.34 1.22e-18 Allergic disease (asthma, hay fever or eczema); BRCA cis rs9399135 1.000 rs35123050 chr6:135302740 G/A cg24558204 chr6:135376177 HBS1L 0.44 11.87 0.42 1.69e-29 Red blood cell count; BRCA cis rs7523050 0.730 rs67312582 chr1:109423976 A/G cg08274380 chr1:109419600 GPSM2 1.18 16.89 0.56 3.31e-53 Fat distribution (HIV); BRCA cis rs7903847 0.596 rs9787426 chr10:99155327 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.53 -0.32 1.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg00012203 chr2:219082015 ARPC2 -0.47 -9.12 -0.34 9.9e-19 Colorectal cancer; BRCA cis rs922692 0.744 rs4886592 chr15:79082547 T/C cg04896959 chr15:78267971 NA 0.37 8.59 0.32 6.75e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg04013093 chr6:42928303 GNMT -0.29 -8.83 -0.33 9.68e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7927592 0.913 rs7106010 chr11:68365212 C/T cg20283391 chr11:68216788 NA -0.47 -9.52 -0.35 3.41e-20 Total body bone mineral density; BRCA cis rs1801251 0.896 rs921054 chr2:233694673 G/A cg08000102 chr2:233561755 GIGYF2 -0.61 -13.4 -0.47 3.02e-36 Coronary artery disease; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg00149659 chr3:10157352 C3orf10 -0.8 -13.7 -0.48 1.21e-37 Alzheimer's disease; BRCA cis rs7178424 1.000 rs11629596 chr15:62370113 G/A cg00456672 chr15:62358751 C2CD4A -0.36 -8.44 -0.32 2.18e-16 Height; BRCA trans rs941408 1.000 rs1736180 chr19:2796021 C/T cg19676328 chr12:49525230 TUBA1B -0.53 -11.88 -0.43 1.45e-29 Total cholesterol levels; BRCA trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg13010199 chr12:38710504 ALG10B 0.42 9.03 0.34 1.94e-18 Morning vs. evening chronotype; BRCA cis rs11690935 0.798 rs13018768 chr2:172598592 A/G cg13550731 chr2:172543902 DYNC1I2 -0.93 -30.91 -0.77 5.4e-129 Schizophrenia; BRCA cis rs7772486 0.754 rs9386133 chr6:146141213 A/G cg23711669 chr6:146136114 FBXO30 0.71 16.56 0.55 1.59e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.06 -0.34 1.61e-18 Bipolar disorder; BRCA trans rs3780486 0.834 rs75443249 chr9:33149207 A/G cg04842962 chr6:43655489 MRPS18A 0.99 22.01 0.66 2.54e-80 IgG glycosylation; BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg00080972 chr5:178986291 RUFY1 -0.48 -13.6 -0.47 3.34e-37 Lung cancer; BRCA cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg08999081 chr20:33150536 PIGU 0.32 8.37 0.31 3.62e-16 Glomerular filtration rate (creatinine); BRCA trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.43 0.35 7.46e-20 Intelligence (multi-trait analysis); BRCA cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg09035930 chr12:129282057 SLC15A4 0.49 14.09 0.49 1.77e-39 Systemic lupus erythematosus; BRCA cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12667521 chr19:29218732 NA 0.47 8.75 0.33 1.93e-17 Methadone dose in opioid dependence; BRCA cis rs1997103 1.000 rs1965556 chr7:55403584 C/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2797160 1.000 rs983543 chr6:126005767 G/A cg05901451 chr6:126070800 HEY2 -0.39 -9.49 -0.35 4.46e-20 Endometrial cancer; BRCA cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg06640241 chr16:89574553 SPG7 0.83 20.56 0.63 1.69e-72 Multiple myeloma (IgH translocation); BRCA cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg16339924 chr4:17578868 LAP3 0.56 13.83 0.48 3.07e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg24531977 chr5:56204891 C5orf35 -0.72 -16.05 -0.54 5.62e-49 Initial pursuit acceleration; BRCA cis rs7103648 0.864 rs12801188 chr11:47388214 G/A cg20307385 chr11:47447363 PSMC3 0.82 20.62 0.63 8.85e-73 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs250677 0.687 rs250672 chr5:148446110 A/G cg23229984 chr5:148520753 ABLIM3 0.36 8.74 0.33 2.06e-17 Breast cancer; BRCA trans rs116095464 0.558 rs9312978 chr5:221930 C/G cg00938859 chr5:1591904 SDHAP3 0.63 8.84 0.33 9.45e-18 Breast cancer; BRCA cis rs4363385 0.747 rs1611753 chr1:152956381 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.86 -0.33 7.58e-18 Inflammatory skin disease; BRCA cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg17971929 chr21:40555470 PSMG1 0.72 15.64 0.53 6.29e-47 Cognitive function; BRCA cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.48 -0.32 1.57e-16 Schizophrenia; BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg00166722 chr3:10149974 C3orf24 0.56 10.01 0.37 5.23e-22 Alzheimer's disease; BRCA trans rs877282 0.945 rs11253390 chr10:788678 A/G cg22713356 chr15:30763199 NA 1.42 28.54 0.75 3.84e-116 Uric acid levels; BRCA cis rs3617 0.625 rs2239548 chr3:52854186 A/C cg11645453 chr3:52864694 ITIH4 0.37 9.75 0.36 4.98e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs2980436 1 rs2980436 chr8:8092025 A/G cg14343924 chr8:8086146 FLJ10661 -0.46 -9.27 -0.34 2.88e-19 Schizophrenia; BRCA cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.33 0.49 1.39e-40 Motion sickness; BRCA trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.48 -0.32 1.51e-16 Extrinsic epigenetic age acceleration; BRCA cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg26031613 chr14:104095156 KLC1 -0.54 -9.58 -0.35 2.12e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs4595586 0.545 rs6580889 chr12:39369742 T/C cg26384229 chr12:38710491 ALG10B 0.4 8.76 0.33 1.71e-17 Morning vs. evening chronotype; BRCA cis rs67460515 0.665 rs28384382 chr3:160939141 C/T cg03342759 chr3:160939853 NMD3 -0.81 -17.59 -0.57 8.74e-57 Parkinson's disease; BRCA cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 7.95 0.3 8.42e-15 Axial length; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg24642844 chr7:1081250 C7orf50 -0.71 -13.92 -0.48 1.13e-38 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13046373 0.535 rs1354866 chr21:31981559 A/T cg22337977 chr21:31811175 KRTAP15-1 0.34 8.34 0.31 4.6e-16 HDL cholesterol; BRCA cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.56 0.32 8.33e-17 Rheumatoid arthritis; BRCA cis rs3791556 0.504 rs1001285 chr2:240107814 A/G cg03281426 chr2:240109471 HDAC4 0.56 12.33 0.44 1.68e-31 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs12586317 0.620 rs7147571 chr14:35530236 T/C cg16230307 chr14:35515116 FAM177A1 0.71 14.39 0.49 7.18e-41 Psoriasis; BRCA cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg20701182 chr2:24300061 SF3B14 0.55 8.53 0.32 1.09e-16 Lymphocyte counts; BRCA cis rs55962025 0.883 rs82334 chr4:3225371 A/C cg27319971 chr4:3255056 C4orf44 -0.4 -7.82 -0.3 2.24e-14 Parental longevity (mother's age at death); BRCA cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg10495392 chr1:46806563 NSUN4 0.46 8.43 0.32 2.32e-16 Menopause (age at onset); BRCA cis rs10751667 0.643 rs7396767 chr11:938808 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.19e-47 Alzheimer's disease (late onset); BRCA cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs742320 0.756 rs3765263 chr16:840378 A/G cg07501729 chr16:846077 CHTF18 0.5 12.14 0.43 1.13e-30 Mean corpuscular volume; BRCA cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.7 -0.33 2.72e-17 Monocyte percentage of white cells; BRCA cis rs3008870 0.755 rs3929738 chr1:67397865 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.09 0.49 1.81e-39 Lymphocyte percentage of white cells; BRCA cis rs9309711 0.737 rs9284795 chr2:3492065 G/A cg16153549 chr2:3496821 NA -0.4 -9.28 -0.34 2.67e-19 Neurofibrillary tangles; BRCA cis rs10924970 0.967 rs4659721 chr1:235426917 C/T cg26050004 chr1:235667680 B3GALNT2 0.34 8.52 0.32 1.18e-16 Asthma; BRCA cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs9378551 chr6:8463744 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.07 0.49 2.26e-39 Motion sickness; BRCA cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg25019033 chr10:957182 NA -0.41 -7.86 -0.3 1.64e-14 Eosinophil percentage of granulocytes; BRCA cis rs265548 0.608 rs36690 chr19:17910483 C/T cg21960279 chr19:17905606 B3GNT3 0.49 11.2 0.41 1.04e-26 Tumor biomarkers; BRCA cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg03146154 chr1:46216737 IPP 0.46 10.14 0.37 1.67e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs561341 1.000 rs530209 chr17:30315287 A/G cg27661571 chr11:113659931 NA -0.71 -10.93 -0.4 1.31e-25 Hip circumference adjusted for BMI; BRCA trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg13010199 chr12:38710504 ALG10B -0.42 -8.84 -0.33 9.39e-18 Morning vs. evening chronotype; BRCA cis rs36051895 0.622 rs12686652 chr9:5071942 C/G cg02405213 chr9:5042618 JAK2 -0.53 -9.62 -0.36 1.5e-20 Pediatric autoimmune diseases; BRCA cis rs36051895 0.593 rs62541903 chr9:5146952 G/C cg02405213 chr9:5042618 JAK2 -0.51 -9.26 -0.34 3e-19 Pediatric autoimmune diseases; BRCA cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.517 rs1843738 chr12:34056935 C/T cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.44e-26 Morning vs. evening chronotype; BRCA cis rs79057730 0.599 rs9458 chr7:825494 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 -0.78 -11.29 -0.41 4.61e-27 Initial pursuit acceleration; BRCA cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg12463550 chr7:65579703 CRCP 0.37 7.93 0.3 9.93e-15 Aortic root size; BRCA cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg02527881 chr3:46936655 PTH1R -0.36 -8.32 -0.31 5.3e-16 Birth weight; BRCA cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg20476274 chr7:133979776 SLC35B4 0.65 19.09 0.6 1.22e-64 Mean platelet volume; BRCA cis rs6088590 1.000 rs10048849 chr20:33419680 C/T cg24642439 chr20:33292090 TP53INP2 0.71 16.22 0.54 8e-50 Coronary artery disease; BRCA cis rs7975161 0.638 rs10861170 chr12:104615957 A/G cg25273343 chr12:104657179 TXNRD1 -0.38 -8.99 -0.34 2.67e-18 Toenail selenium levels; BRCA cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg17330251 chr7:94953956 PON1 -0.43 -8.9 -0.33 5.84e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg18876405 chr7:65276391 NA 0.71 18.7 0.59 1.48e-62 Aortic root size; BRCA trans rs11098499 0.863 rs58452170 chr4:120459674 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.38 8.59 0.32 6.41e-17 Corneal astigmatism; BRCA cis rs2236521 0.714 rs6062210 chr20:60890375 A/G cg09594475 chr20:60884601 LAMA5 0.5 11.57 0.42 3.21e-28 Pelvic organ prolapse; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg25036284 chr2:26402008 FAM59B -0.81 -14.53 -0.5 1.5e-41 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs2832077 0.943 rs2832106 chr21:30191767 A/G cg14791747 chr16:20752902 THUMPD1 0.41 9.59 0.35 1.96e-20 Cognitive test performance; BRCA cis rs7904368 0.806 rs45495501 chr10:16861476 G/A cg23933602 chr10:16859644 RSU1 0.55 8.63 0.32 4.98e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg26384229 chr12:38710491 ALG10B 0.58 13.27 0.46 1.1e-35 Morning vs. evening chronotype; BRCA cis rs6912958 0.754 rs10755484 chr6:88244648 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.57 -0.32 7.63e-17 Monocyte percentage of white cells; BRCA cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.03e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4919694 0.667 rs75890466 chr10:105076383 C/T cg04362960 chr10:104952993 NT5C2 0.75 10.4 0.38 1.69e-23 Arsenic metabolism; BRCA cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.71e-23 Motion sickness; BRCA cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 11.16 0.4 1.47e-26 Personality dimensions; BRCA cis rs910316 0.967 rs4899549 chr14:75647494 G/A cg23033748 chr14:75592666 NEK9 -0.42 -10.06 -0.37 3.33e-22 Height; BRCA cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg12011299 chr4:100065546 ADH4 -0.37 -10.65 -0.39 1.71e-24 Alcohol dependence; BRCA cis rs250677 0.687 rs185155 chr5:148455893 T/C cg12140854 chr5:148520817 ABLIM3 -0.42 -8.85 -0.33 8.72e-18 Breast cancer; BRCA trans rs56176327 0.583 rs7613603 chr3:49812866 C/T cg21659725 chr3:3221576 CRBN 0.48 8.7 0.33 2.83e-17 Intelligence (multi-trait analysis); BRCA cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg12365402 chr11:9010492 NRIP3 -0.41 -9.47 -0.35 5.2e-20 Hemoglobin concentration; BRCA cis rs478304 0.651 rs11600918 chr11:65511965 A/G cg10518572 chr11:65560635 OVOL1 -0.3 -8.44 -0.32 2.07e-16 Acne (severe); BRCA cis rs9400271 0.632 rs9384705 chr6:109588244 T/C cg21918786 chr6:109611834 NA -0.32 -8.06 -0.3 3.67e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg22920501 chr2:26401640 FAM59B -0.84 -16.01 -0.54 9.42e-49 Gut microbiome composition (summer); BRCA cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg11822812 chr5:140052017 DND1 0.31 8.4 0.32 2.86e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs514406 0.505 rs448788 chr1:53161620 A/G cg08859206 chr1:53392774 SCP2 0.41 8.25 0.31 9.33e-16 Monocyte count; BRCA cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg00277334 chr10:82204260 NA -0.85 -24.82 -0.7 9.19e-96 Post bronchodilator FEV1; BRCA cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg13319975 chr6:146136371 FBXO30 -0.42 -9.57 -0.35 2.32e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs698833 0.962 rs1067387 chr2:44642797 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.71 0.39 1.02e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7395581 1.000 rs7395581 chr11:47246397 G/A cg25783544 chr11:47291846 MADD -0.43 -9.56 -0.35 2.45e-20 HDL cholesterol; BRCA cis rs9403521 1.000 rs9403521 chr6:143994199 C/T cg18240653 chr6:144019428 PHACTR2 0.42 8.54 0.32 9.63e-17 Obesity-related traits; BRCA cis rs3784262 0.528 rs4238327 chr15:58336218 C/T cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.13 -0.37 1.86e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg26597838 chr10:835615 NA 1.01 15.56 0.52 1.59e-46 Eosinophil percentage of granulocytes; BRCA cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs11955398 0.585 rs4700384 chr5:60032471 T/C cg02684056 chr5:59996105 DEPDC1B -0.38 -8.96 -0.33 3.63e-18 Intelligence (multi-trait analysis); BRCA cis rs1865721 1.000 rs62089508 chr18:73193344 C/T cg26385618 chr18:73139727 C18orf62 -0.39 -9.0 -0.34 2.66e-18 Intelligence; BRCA cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg24558204 chr6:135376177 HBS1L -0.49 -13.85 -0.48 2.52e-38 Red blood cell count; BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg25036284 chr2:26402008 FAM59B 0.95 15.83 0.53 7.3e-48 Mean corpuscular hemoglobin; BRCA cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg06618935 chr21:46677482 NA -0.36 -8.0 -0.3 5.85e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1568889 0.838 rs716366 chr11:28121536 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 20.06 0.62 9.05e-70 Bipolar disorder; BRCA cis rs1797081 0.934 rs1797077 chr10:16853252 C/T cg23933602 chr10:16859644 RSU1 0.97 28.12 0.74 7.8e-114 Platelet distribution width; BRCA cis rs6763687 0.725 rs9841998 chr3:171802979 C/T cg16233210 chr3:171778391 FNDC3B 0.35 7.97 0.3 7.57e-15 Red cell distribution width; BRCA cis rs12458462 0.892 rs3786228 chr18:77464170 C/T cg11879182 chr18:77439856 CTDP1 -0.66 -14.2 -0.49 5.6e-40 Monocyte count; BRCA cis rs6893300 0.826 rs7734102 chr5:179153797 A/G cg14593053 chr5:179126677 CANX 0.34 7.88 0.3 1.37e-14 Resting heart rate; BRCA cis rs7799006 0.862 rs3757439 chr7:2272122 C/T cg08027265 chr7:2291960 NA -0.4 -10.25 -0.38 6.08e-23 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.61e-27 Extrinsic epigenetic age acceleration; BRCA cis rs2806561 0.828 rs944509 chr1:23542242 C/T cg12483005 chr1:23474871 LUZP1 -0.37 -8.04 -0.3 4.35e-15 Height; BRCA cis rs11718455 0.960 rs35277738 chr3:44006732 T/C cg08738300 chr3:44038990 NA 0.45 8.7 0.33 2.74e-17 Coronary artery disease; BRCA cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg27478167 chr7:817139 HEATR2 -0.55 -11.37 -0.41 2.15e-27 Cerebrospinal P-tau181p levels; BRCA cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.41e-20 Menopause (age at onset); BRCA cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.11 0.43 1.51e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs208520 1.000 rs12191403 chr6:66978137 C/T cg07460842 chr6:66804631 NA 0.87 14.19 0.49 6.35e-40 Exhaled nitric oxide output; BRCA cis rs11229555 1.000 rs8373 chr11:58378424 A/G cg15696309 chr11:58395628 NA -0.53 -11.62 -0.42 1.95e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6963495 0.745 rs73190169 chr7:105160500 A/G cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg11752832 chr7:134001865 SLC35B4 0.52 13.43 0.47 2.22e-36 Mean platelet volume; BRCA trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.03e-14 Corneal astigmatism; BRCA cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg26874164 chr19:58962979 ZNF324B 0.51 11.19 0.4 1.16e-26 Uric acid clearance; BRCA cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg12373951 chr3:133503437 NA 0.45 10.49 0.38 7.13e-24 Iron status biomarkers; BRCA cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg08917208 chr2:24149416 ATAD2B 0.91 13.38 0.47 3.55e-36 Lymphocyte counts; BRCA cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg05535760 chr7:792225 HEATR2 0.73 13.12 0.46 5.7e-35 Cerebrospinal P-tau181p levels; BRCA cis rs875971 0.862 rs937494 chr7:65764678 T/A cg11764359 chr7:65958608 NA -0.77 -17.65 -0.57 4.23e-57 Aortic root size; BRCA cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg06064525 chr11:970664 AP2A2 -0.49 -16.18 -0.54 1.25e-49 Alzheimer's disease (late onset); BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs1865760 0.865 rs9467652 chr6:25959127 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.38e-21 Height; BRCA cis rs7607369 0.714 rs4674332 chr2:219604326 C/T cg02176678 chr2:219576539 TTLL4 0.44 11.2 0.41 1.05e-26 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26314531 chr2:26401878 FAM59B -0.63 -11.15 -0.4 1.74e-26 Gut microbiome composition (summer); BRCA cis rs1153858 0.621 rs12913645 chr15:45555066 G/A cg14582100 chr15:45693742 SPATA5L1 -0.29 -8.49 -0.32 1.47e-16 Homoarginine levels; BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg08470875 chr2:26401718 FAM59B -0.58 -9.23 -0.34 3.84e-19 Gut microbiome composition (summer); BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg09177884 chr7:1199841 ZFAND2A -0.59 -13.84 -0.48 2.76e-38 Longevity;Endometriosis; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -8.3 -0.31 6.43e-16 Longevity;Endometriosis; BRCA trans rs561341 1.000 rs501312 chr17:30329066 A/G cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.36e-27 Hip circumference adjusted for BMI; BRCA cis rs77741769 0.571 rs3883901 chr12:121256520 A/G cg02419362 chr12:121203948 SPPL3 0.34 8.01 0.3 5.65e-15 Mean corpuscular volume; BRCA cis rs9818758 0.607 rs71324929 chr3:49044713 C/T cg00383909 chr3:49044727 WDR6 1.02 15.12 0.51 2.11e-44 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7927771 0.524 rs7116346 chr11:47883880 G/A cg20307385 chr11:47447363 PSMC3 -0.39 -9.17 -0.34 6.2800000000000005e-19 Subjective well-being; BRCA cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg27446573 chr6:127587934 RNF146 0.86 19.7 0.61 7.62e-68 Breast cancer; BRCA cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg01114163 chr5:1856713 NA -0.36 -8.08 -0.3 3.36e-15 Cardiovascular disease risk factors; BRCA cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.32 -0.31 5.32e-16 Colorectal cancer; BRCA trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg15704280 chr7:45808275 SEPT13 -0.71 -13.46 -0.47 1.55e-36 Coronary artery disease; BRCA cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg05347473 chr6:146136440 FBXO30 0.6 11.4 0.41 1.55e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.667 rs78426057 chr1:152964528 T/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.15 -0.34 7.37e-19 Inflammatory skin disease; BRCA cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg02659138 chr7:134003124 SLC35B4 0.33 10.34 0.38 2.74e-23 Mean platelet volume; BRCA trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21582582 chr3:182698605 DCUN1D1 0.38 9.84 0.36 2.34e-21 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.5 0.38 6.56e-24 Mean corpuscular volume; BRCA cis rs6750047 0.609 rs2121259 chr2:38269475 T/C cg07380506 chr2:38303506 CYP1B1 0.47 10.19 0.37 1.09e-22 Cutaneous malignant melanoma;Melanoma; BRCA cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg04455712 chr21:45112962 RRP1B 0.41 11.09 0.4 2.84e-26 Mean corpuscular volume; BRCA cis rs2880765 0.835 rs12910373 chr15:86046802 G/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.5 -0.32 1.34e-16 Coronary artery disease; BRCA cis rs9549260 0.564 rs6563844 chr13:41298190 T/C cg21288729 chr13:41239152 FOXO1 0.5 10.19 0.37 1.04e-22 Red blood cell count; BRCA cis rs2386661 0.603 rs11259704 chr10:5646999 C/T cg17085576 chr10:5658249 NA -0.32 -8.15 -0.31 1.99e-15 Breast cancer; BRCA cis rs7666738 0.830 rs79075162 chr4:98960674 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs877529 0.625 rs713841 chr22:39529029 A/G cg12193277 chr22:39547181 CBX7 0.36 8.49 0.32 1.49e-16 Multiple myeloma; BRCA cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg18876405 chr7:65276391 NA -0.54 -11.97 -0.43 6.03e-30 Calcium levels; BRCA cis rs829883 0.659 rs4762495 chr12:98934105 C/T cg25150519 chr12:98850993 NA -0.5 -9.1 -0.34 1.1e-18 Colorectal adenoma (advanced); BRCA cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.22 0.31 1.15e-15 Cognitive ability; BRCA cis rs9287719 0.967 rs6709466 chr2:10748257 T/C cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.9 -0.3 1.26e-14 Corneal astigmatism; BRCA cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.03 0.54 7.54e-49 Smoking behavior; BRCA trans rs3780486 0.813 rs3780488 chr9:33133812 T/C cg20290983 chr6:43655470 MRPS18A 1.1 40.23 0.85 2.86e-177 IgG glycosylation; BRCA cis rs832540 0.656 rs702689 chr5:56177443 G/A cg18230493 chr5:56204884 C5orf35 -0.4 -8.2 -0.31 1.36e-15 Coronary artery disease; BRCA cis rs6963495 0.818 rs73190181 chr7:105162907 A/C cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs2625529 0.526 rs8032222 chr15:72479178 C/G cg16672083 chr15:72433130 SENP8 0.66 15.56 0.52 1.6e-46 Red blood cell count; BRCA cis rs2046867 0.774 rs1393585 chr3:72886722 A/G cg25664220 chr3:72788482 NA -0.55 -11.84 -0.42 2.17e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg11707556 chr5:10655725 ANKRD33B 0.44 9.72 0.36 6.14e-21 Height; BRCA cis rs7927771 0.524 rs6485786 chr11:47837408 G/C cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Subjective well-being; BRCA cis rs116095464 0.558 rs10055993 chr5:264296 A/C cg22496380 chr5:211416 CCDC127 -0.98 -12.36 -0.44 1.25e-31 Breast cancer; BRCA cis rs4919694 0.901 rs10509763 chr10:104776391 G/A cg04362960 chr10:104952993 NT5C2 0.94 14.57 0.5 1.05e-41 Arsenic metabolism; BRCA cis rs757110 0.866 rs5215 chr11:17408630 C/T cg03864215 chr11:17408437 KCNJ11 -0.27 -8.07 -0.3 3.43e-15 Type 2 diabetes; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg14004847 chr7:1930337 MAD1L1 -0.44 -8.97 -0.33 3.35e-18 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.14 -20.54 -0.63 2.19e-72 Platelet count; BRCA cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg19901468 chr14:105411992 AHNAK2 -0.51 -12.45 -0.44 5.15e-32 Rheumatoid arthritis; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg04709771 chr16:646395 RAB40C 0.43 10.73 0.39 8.15e-25 Height; BRCA cis rs9287719 0.649 rs6717431 chr2:10726046 A/G cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs798554 0.660 rs798480 chr7:2805597 G/T cg09658497 chr7:2847517 GNA12 -0.4 -8.04 -0.3 4.27e-15 Height; BRCA cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.97 0.43 5.92e-30 Lung cancer in ever smokers; BRCA trans rs61931739 0.500 rs56404399 chr12:34543101 A/G cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs7103648 0.735 rs3824869 chr11:47378245 T/C cg03711944 chr11:47377212 SPI1 0.47 11.97 0.43 6.52e-30 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9733 0.596 rs12077833 chr1:150674333 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.88 0.3 1.37e-14 Tonsillectomy; BRCA cis rs6121246 0.821 rs6058448 chr20:30332396 C/T cg21427119 chr20:30132790 HM13 -0.41 -8.78 -0.33 1.53e-17 Mean corpuscular hemoglobin; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg14004847 chr7:1930337 MAD1L1 -0.44 -8.95 -0.33 3.78e-18 Bipolar disorder and schizophrenia; BRCA cis rs1891275 0.515 rs10881957 chr10:93501876 C/T cg07889827 chr10:93443413 NA -0.4 -10.82 -0.39 3.59e-25 Intelligence (multi-trait analysis); BRCA cis rs10910092 1 rs10910092 chr1:2501516 A/G cg20673091 chr1:2541236 MMEL1 0.33 8.7 0.33 2.74e-17 Ulcerative colitis; BRCA cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg23711669 chr6:146136114 FBXO30 0.84 20.16 0.62 2.62e-70 Lobe attachment (rater-scored or self-reported); BRCA cis rs11758351 1.000 rs2143347 chr6:26198494 C/T cg01420254 chr6:26195488 NA 0.58 9.04 0.34 1.8e-18 Gout;Renal underexcretion gout; BRCA cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg12193833 chr17:30244370 NA -0.55 -8.18 -0.31 1.53e-15 Hip circumference adjusted for BMI; BRCA cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg06115741 chr20:33292138 TP53INP2 0.39 8.58 0.32 7.18e-17 Glomerular filtration rate (creatinine); BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg13047869 chr3:10149882 C3orf24 0.58 12.11 0.43 1.53e-30 Alzheimer's disease; BRCA cis rs17685 0.753 rs4732595 chr7:75755139 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -9.17 -0.34 6.34e-19 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg23711669 chr6:146136114 FBXO30 -0.75 -17.43 -0.57 5.61e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00166722 chr3:10149974 C3orf24 0.56 9.97 0.37 7.6e-22 Alzheimer's disease; BRCA cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg24642439 chr20:33292090 TP53INP2 0.68 15.27 0.52 4.35e-45 Coronary artery disease; BRCA cis rs1003719 0.699 rs1015549 chr21:38448880 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.26e-40 Eye color traits; BRCA cis rs2749592 0.550 rs9733309 chr10:37882405 G/A cg25427524 chr10:38739819 LOC399744 0.6 13.52 0.47 7.88e-37 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2625529 0.590 rs2607090 chr15:72496011 C/A cg16672083 chr15:72433130 SENP8 -0.83 -17.35 -0.57 1.52e-55 Red blood cell count; BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg08888203 chr3:10149979 C3orf24 0.57 12.08 0.43 2.15e-30 Alzheimer's disease; BRCA cis rs738322 0.511 rs5756947 chr22:38573230 G/A cg25457927 chr22:38595422 NA -0.36 -12.03 -0.43 3.59e-30 Cutaneous nevi; BRCA cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg22800045 chr5:56110881 MAP3K1 0.63 10.98 0.4 7.99e-26 Initial pursuit acceleration; BRCA cis rs7944584 0.511 rs10838731 chr11:47607135 C/T cg20307385 chr11:47447363 PSMC3 0.8 19.15 0.6 6.32e-65 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6066825 0.644 rs6090894 chr20:47334688 G/T cg18078177 chr20:47281410 PREX1 0.39 9.45 0.35 6.45e-20 Colorectal cancer; BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg22535103 chr8:58192502 C8orf71 -0.49 -8.71 -0.33 2.62e-17 Developmental language disorder (linguistic errors); BRCA trans rs941408 1.000 rs2260416 chr19:2796355 G/A cg19676328 chr12:49525230 TUBA1B -0.53 -11.8 -0.42 3.3e-29 Total cholesterol levels; BRCA trans rs75804782 0.521 rs72982590 chr2:239451826 T/C cg01134436 chr17:81009848 B3GNTL1 0.68 8.89 0.33 6.04e-18 Morning vs. evening chronotype;Chronotype; BRCA cis rs9325144 0.752 rs12300353 chr12:39154492 G/C cg26384229 chr12:38710491 ALG10B -0.5 -11.13 -0.4 2.02e-26 Morning vs. evening chronotype; BRCA trans rs3733585 0.624 rs76574510 chr4:9953252 T/A cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg05863683 chr7:1912471 MAD1L1 0.36 8.37 0.31 3.6e-16 Bipolar disorder and schizophrenia; BRCA cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg10802521 chr3:52805072 NEK4 -0.34 -9.24 -0.34 3.68e-19 Bipolar disorder; BRCA cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.35 0.38 2.49e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8114671 0.836 rs3746432 chr20:33592763 C/T cg24642439 chr20:33292090 TP53INP2 -0.43 -8.74 -0.33 2.01e-17 Height; BRCA trans rs11098499 0.863 rs3822190 chr4:120428098 G/A cg25214090 chr10:38739885 LOC399744 0.55 11.82 0.42 2.68e-29 Corneal astigmatism; BRCA cis rs6901250 0.851 rs6938235 chr6:117147946 G/T cg12892004 chr6:117198278 RFX6 0.47 10.92 0.4 1.44e-25 C-reactive protein levels; BRCA cis rs801193 0.761 rs2659888 chr7:66230171 T/G cg18876405 chr7:65276391 NA 0.61 15.16 0.51 1.42e-44 Aortic root size; BRCA cis rs9486719 1.000 rs28623445 chr6:96899116 G/T cg06623918 chr6:96969491 KIAA0776 -0.72 -12.94 -0.46 3.55e-34 Migraine;Coronary artery disease; BRCA cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg05234568 chr11:5960015 NA 0.4 8.43 0.32 2.35e-16 DNA methylation (variation); BRCA cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg24642439 chr20:33292090 TP53INP2 -0.55 -11.83 -0.42 2.57e-29 Glomerular filtration rate (creatinine); BRCA trans rs8002861 0.905 rs9525869 chr13:44467210 A/G cg17145862 chr1:211918768 LPGAT1 0.73 19.51 0.61 7.82e-67 Leprosy; BRCA trans rs1941687 0.505 rs12605642 chr18:31313965 G/T cg15819921 chr19:927150 ARID3A -0.42 -8.1 -0.31 2.77e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA cis rs2050392 0.624 rs303435 chr10:30731491 T/C cg18806716 chr10:30721971 MAP3K8 -0.55 -13.09 -0.46 7.4e-35 Inflammatory bowel disease; BRCA cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg05347473 chr6:146136440 FBXO30 0.61 12.12 0.43 1.47e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs3213545 0.700 rs10849829 chr12:121470256 A/G cg02403541 chr12:121454288 C12orf43 -0.54 -11.69 -0.42 9.97e-29 Subjective well-being;Cardiovascular disease risk factors; BRCA cis rs9649465 1.000 rs627689 chr7:123400543 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.28 -0.31 7.3e-16 Migraine; BRCA cis rs7789940 0.810 rs12533978 chr7:75943352 T/C cg10167463 chr7:75959203 YWHAG -0.45 -8.85 -0.33 8.55e-18 Multiple sclerosis; BRCA cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg06022373 chr22:39101656 GTPBP1 0.66 15.17 0.51 1.21e-44 Menopause (age at onset); BRCA cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg01448562 chr3:133502909 NA 0.48 10.6 0.39 2.7e-24 Iron status biomarkers; BRCA cis rs7715811 1.000 rs2896103 chr5:13764419 G/A cg07548982 chr5:13769939 DNAH5 -0.38 -8.46 -0.32 1.87e-16 Subclinical atherosclerosis traits (other); BRCA cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg11693508 chr17:37793320 STARD3 0.59 11.14 0.4 1.92e-26 Bipolar disorder; BRCA cis rs1568889 0.641 rs34857148 chr11:28481976 T/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.51 8.78 0.33 1.51e-17 Bipolar disorder; BRCA cis rs9790314 0.936 rs336572 chr3:161068014 G/A cg03342759 chr3:160939853 NMD3 -0.55 -12.28 -0.44 2.94e-31 Morning vs. evening chronotype; BRCA cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg07395648 chr5:131743802 NA 0.38 9.51 0.35 3.67e-20 Blood metabolite levels; BRCA cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg02221750 chr19:17393354 ANKLE1 0.66 12.53 0.44 2.28e-32 Systemic lupus erythematosus; BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg26314531 chr2:26401878 FAM59B -0.63 -10.75 -0.39 7.14e-25 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg22920501 chr2:26401640 FAM59B -0.66 -11.44 -0.41 1.1e-27 Gut microbiome composition (summer); BRCA cis rs10911232 0.507 rs5022057 chr1:182997761 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs910316 0.737 rs175499 chr14:75535927 G/A cg11812906 chr14:75593930 NEK9 -0.6 -13.43 -0.47 2.1e-36 Height; BRCA trans rs66887589 0.616 rs1052633 chr4:120215314 A/G cg25214090 chr10:38739885 LOC399744 0.37 8.54 0.32 1e-16 Diastolic blood pressure; BRCA cis rs2901460 0.509 rs66481227 chr2:62117600 C/T cg02183531 chr2:62113199 CCT4 -0.45 -9.01 -0.34 2.31e-18 Mean corpuscular volume; BRCA cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg01283332 chr5:1856932 NA -0.32 -7.96 -0.3 7.68e-15 Cardiovascular disease risk factors; BRCA cis rs7927771 0.894 rs12798346 chr11:47583121 C/T cg18512352 chr11:47633146 NA -0.37 -9.1 -0.34 1.1e-18 Subjective well-being; BRCA cis rs2645694 0.626 rs2645684 chr4:77819892 A/C cg18351406 chr4:77819688 ANKRD56 0.61 13.3 0.47 7.98e-36 Emphysema distribution in smoking; BRCA trans rs4650994 0.524 rs2476558 chr1:178580953 C/T cg05059571 chr16:84539110 KIAA1609 0.52 11.58 0.42 2.69e-28 HDL cholesterol levels;HDL cholesterol; BRCA cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.24 -0.41 7.16e-27 Schizophrenia; BRCA cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg04317338 chr11:64019027 PLCB3 0.59 9.95 0.37 9.1e-22 Mean platelet volume; BRCA cis rs3892630 0.878 rs6510277 chr19:33183669 C/A cg22980127 chr19:33182716 NUDT19 0.89 17.96 0.58 1.09e-58 Red blood cell traits; BRCA cis rs2070488 1.000 rs13089394 chr3:38446309 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.74 20.3 0.63 4.28e-71 Electrocardiographic conduction measures; BRCA cis rs7020830 0.789 rs17408112 chr9:37114065 A/G cg14294708 chr9:37120828 ZCCHC7 1.17 41.02 0.85 3.52e-181 Schizophrenia; BRCA cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg11833968 chr6:79620685 NA 0.43 9.66 0.36 1.04e-20 Intelligence (multi-trait analysis); BRCA trans rs8073060 0.963 rs11080354 chr17:33872407 A/G cg19694781 chr19:47549865 TMEM160 -0.57 -11.93 -0.43 9.48e-30 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7264396 0.635 rs6060696 chr20:34522060 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.86 0.3 1.62e-14 Total cholesterol levels; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg04267008 chr7:1944627 MAD1L1 -0.62 -13.53 -0.47 7.69e-37 Bipolar disorder and schizophrenia; BRCA cis rs894734 0.535 rs7301643 chr12:54325796 G/T cg25024717 chr12:54324583 NA -0.3 -8.15 -0.31 1.88e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg13397359 chr6:42928475 GNMT 0.66 15.96 0.53 1.66e-48 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.73e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9311474 0.629 rs9853056 chr3:52555957 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.36 -8.47 -0.32 1.63e-16 Electroencephalogram traits; BRCA cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.32e-26 Extrinsic epigenetic age acceleration; BRCA cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg04727924 chr7:799746 HEATR2 -0.53 -9.28 -0.34 2.62e-19 Cerebrospinal P-tau181p levels; BRCA cis rs2072499 0.966 rs2842865 chr1:156159532 G/A cg24450063 chr1:156163899 SLC25A44 1.12 36.14 0.82 1.26e-156 Testicular germ cell tumor; BRCA cis rs2836974 0.830 rs2735309 chr21:40715313 C/T cg11890956 chr21:40555474 PSMG1 0.94 23.07 0.67 3.71e-86 Cognitive function; BRCA cis rs35146811 0.696 rs1727124 chr7:99804104 T/G cg13334819 chr7:99746414 C7orf59 0.34 7.96 0.3 8.13e-15 Coronary artery disease; BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg08888203 chr3:10149979 C3orf24 0.67 14.11 0.49 1.55e-39 Alzheimer's disease; BRCA cis rs13136331 0.606 rs7686829 chr4:88639710 A/G cg22416721 chr4:88570574 DMP1 -0.47 -11.53 -0.41 4.65e-28 Sitting height ratio; BRCA cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.48e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.586 rs73021449 chr3:161128941 G/A cg03342759 chr3:160939853 NMD3 -0.63 -14.12 -0.49 1.34e-39 Morning vs. evening chronotype; BRCA cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg08917208 chr2:24149416 ATAD2B -0.55 -8.44 -0.32 2.19e-16 Lymphocyte counts; BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg02951883 chr7:2050386 MAD1L1 0.51 11.96 0.43 7.03e-30 Bipolar disorder and schizophrenia; BRCA cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.54 -11.56 -0.42 3.29e-28 Colorectal cancer; BRCA cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg18876405 chr7:65276391 NA -0.51 -11.63 -0.42 1.67e-28 Aortic root size; BRCA cis rs9287719 0.967 rs715246 chr2:10736355 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA trans rs8073060 0.586 rs4796101 chr17:33998593 C/T cg19694781 chr19:47549865 TMEM160 -1.02 -21.14 -0.64 1.31e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg06713675 chr4:122721982 EXOSC9 -0.54 -12.7 -0.45 4.32e-33 Type 2 diabetes; BRCA cis rs8114671 0.836 rs6060165 chr20:33619480 A/C cg07148914 chr20:33460835 GGT7 -0.41 -9.07 -0.34 1.5e-18 Height; BRCA cis rs7666738 0.830 rs10001702 chr4:99065160 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.89 0.4 1.87e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg25173405 chr17:45401733 C17orf57 -0.54 -11.12 -0.4 2.26e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs651907 0.557 rs17347644 chr3:101547733 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 12.49 0.44 3.38e-32 Colorectal cancer; BRCA cis rs858239 0.600 rs7784929 chr7:23124277 T/C cg23682824 chr7:23144976 KLHL7 0.45 11.82 0.42 2.65e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg11663144 chr21:46675770 NA -0.6 -14.01 -0.48 4.47e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11098499 0.605 rs6833140 chr4:120266822 G/A cg25214090 chr10:38739885 LOC399744 0.43 10.08 0.37 2.74e-22 Corneal astigmatism; BRCA cis rs9291683 0.588 rs3796842 chr4:9995851 A/T cg11266682 chr4:10021025 SLC2A9 0.42 11.31 0.41 3.68e-27 Bone mineral density; BRCA cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg17063962 chr7:91808500 NA 0.52 12.31 0.44 2.06e-31 Breast cancer; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg13047869 chr3:10149882 C3orf24 0.57 10.44 0.38 1.15e-23 Alzheimer's disease; BRCA cis rs35306767 0.668 rs12784928 chr10:1083617 A/C cg20503657 chr10:835505 NA 0.61 10.44 0.38 1.14e-23 Eosinophil percentage of granulocytes; BRCA cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg13119609 chr19:45449297 APOC2 0.47 13.11 0.46 6.03e-35 Blood protein levels; BRCA cis rs3820928 0.874 rs2177593 chr2:227833869 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.41 -0.32 2.71e-16 Pulmonary function; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg18402987 chr7:1209562 NA 0.42 8.63 0.32 4.77e-17 Longevity;Endometriosis; BRCA trans rs1459104 1.000 rs17580126 chr11:55289993 C/G cg15704280 chr7:45808275 SEPT13 -0.63 -8.07 -0.3 3.6e-15 Body mass index; BRCA cis rs7267979 1.000 rs2482927 chr20:25327151 T/C cg08601574 chr20:25228251 PYGB -0.4 -9.21 -0.34 4.65e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1949733 0.554 rs4259044 chr4:8536188 A/G cg11789530 chr4:8429930 ACOX3 -0.45 -10.59 -0.39 3.09e-24 Response to antineoplastic agents; BRCA cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg02297831 chr4:17616191 MED28 0.36 8.33 0.31 4.85e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs926392 0.965 rs6129168 chr20:37689360 T/C cg16355469 chr20:37678765 NA 0.33 8.16 0.31 1.72e-15 Dialysis-related mortality; BRCA cis rs7312933 0.558 rs11181502 chr12:42823833 A/G cg01256987 chr12:42539512 GXYLT1 -0.42 -8.08 -0.3 3.18e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs7395662 0.681 rs2865641 chr11:48941099 A/C cg00717180 chr2:96193071 NA -0.31 -8.59 -0.32 6.53e-17 HDL cholesterol; BRCA cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg14500267 chr11:67383377 NA 0.4 8.34 0.31 4.53e-16 Mean corpuscular volume; BRCA cis rs7520050 0.966 rs61783220 chr1:46335312 G/A cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg16006841 chr5:176797999 RGS14 0.59 11.72 0.42 7e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs78456975 1.000 rs7584264 chr2:1565555 A/G cg01028140 chr2:1542097 TPO -0.68 -13.38 -0.47 3.41e-36 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7918232 0.830 rs9833 chr10:27400861 G/A cg14442939 chr10:27389572 ANKRD26 0.69 10.94 0.4 1.24e-25 Breast cancer; BRCA cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg26384229 chr12:38710491 ALG10B 0.69 15.68 0.53 4.01e-47 Bladder cancer; BRCA cis rs8062405 1.000 rs8055982 chr16:28881202 A/C cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg08470875 chr2:26401718 FAM59B -0.7 -11.27 -0.41 5.41e-27 Gut microbiome composition (summer); BRCA cis rs7523273 0.606 rs2488254 chr1:207941539 A/G cg22525895 chr1:207977042 MIR29B2 0.47 12.0 0.43 4.8e-30 Schizophrenia; BRCA cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg24130564 chr14:104152367 KLC1 -0.34 -7.93 -0.3 9.92e-15 Body mass index; BRCA cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg05294307 chr14:35346193 BAZ1A -0.59 -10.3 -0.38 4.09e-23 Psoriasis; BRCA cis rs3824344 0.545 rs6476606 chr9:37005561 A/G cg14294708 chr9:37120828 ZCCHC7 0.44 8.94 0.33 4.1e-18 Intelligence; BRCA trans rs208520 0.690 rs207096 chr6:66797287 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.01 -0.64 6.5e-75 Exhaled nitric oxide output; BRCA cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.54 11.21 0.41 9.78e-27 Personality dimensions; BRCA cis rs9487051 0.768 rs1766814 chr6:109526696 G/A cg01475377 chr6:109611718 NA -0.41 -10.29 -0.38 4.52e-23 Reticulocyte fraction of red cells; BRCA cis rs7582180 0.700 rs4851303 chr2:100962064 T/C cg14675211 chr2:100938903 LONRF2 0.44 9.73 0.36 5.87e-21 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg22875332 chr1:76189707 ACADM 0.78 21.31 0.64 1.53e-76 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9296092 0.560 rs9469511 chr6:33530930 T/G cg13560919 chr6:33536144 NA -0.85 -17.98 -0.58 8.28e-59 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs3820928 0.605 rs6748311 chr2:227792530 T/A cg05526886 chr2:227700861 RHBDD1 -0.42 -8.7 -0.33 2.89e-17 Pulmonary function; BRCA cis rs12893668 0.703 rs729438 chr14:104092789 A/G cg01849466 chr14:104193079 ZFYVE21 0.35 7.9 0.3 1.26e-14 Reticulocyte count; BRCA cis rs77972916 0.505 rs6756575 chr2:43528519 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.68 -11.55 -0.42 3.55e-28 Granulocyte percentage of myeloid white cells; BRCA trans rs11098499 0.661 rs10015965 chr4:120268237 A/G cg25214090 chr10:38739885 LOC399744 0.43 9.99 0.37 6.39e-22 Corneal astigmatism; BRCA cis rs10752881 1.000 rs10737237 chr1:182989269 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.88 0.56 3.66e-53 Colorectal cancer; BRCA cis rs813218 0.523 rs10935917 chr3:99441241 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -9.3 -0.35 2.16e-19 Orofacial clefts; BRCA cis rs561341 1.000 rs113676348 chr17:30244327 A/G cg00745463 chr17:30367425 LRRC37B -0.5 -8.55 -0.32 9.36e-17 Hip circumference adjusted for BMI; BRCA cis rs10754283 0.934 rs6428563 chr1:90111583 T/A cg21401794 chr1:90099060 LRRC8C 0.45 10.93 0.4 1.25e-25 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7584330 0.740 rs11891348 chr2:238440449 T/G cg14458575 chr2:238380390 NA 0.48 9.99 0.37 5.99e-22 Prostate cancer; BRCA trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg17470723 chr8:74884337 TCEB1 0.4 8.63 0.32 4.92e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7833790 0.724 rs4739627 chr8:82734657 A/G cg02079420 chr8:82753780 SNX16 0.32 8.64 0.32 4.33e-17 Diastolic blood pressure; BRCA cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.1 0.49 1.73e-39 Motion sickness; BRCA cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg23205692 chr1:25664452 TMEM50A 0.38 9.15 0.34 7.39e-19 Erythrocyte sedimentation rate; BRCA cis rs34172651 0.917 rs2059134 chr16:24816492 C/T cg00152838 chr16:24741724 TNRC6A 0.36 8.14 0.31 2.06e-15 Intelligence (multi-trait analysis); BRCA cis rs10504073 0.647 rs4873314 chr8:50011656 A/C cg00325661 chr8:49890786 NA 0.47 13.22 0.46 1.95e-35 Blood metabolite ratios; BRCA cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.37 0.49 8.98e-41 Motion sickness; BRCA cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg13114125 chr14:105738426 BRF1 -0.5 -10.41 -0.38 1.44e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs2153535 0.580 rs9406143 chr6:8444583 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs2251381 0.750 rs2251186 chr21:30528880 G/A cg24692254 chr21:30365293 RNF160 0.63 13.91 0.48 1.32e-38 Selective IgA deficiency; BRCA cis rs6598955 0.671 rs7551557 chr1:26596614 G/A cg04990556 chr1:26633338 UBXN11 0.55 8.51 0.32 1.19e-16 Obesity-related traits; BRCA cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg03146154 chr1:46216737 IPP -0.44 -9.62 -0.36 1.5e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg11366901 chr6:160182831 ACAT2 0.8 14.99 0.51 9.73e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg13902645 chr11:5959945 NA -0.57 -11.54 -0.42 4e-28 DNA methylation (variation); BRCA cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg25554036 chr4:6271136 WFS1 0.39 9.58 0.35 2.11e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg12756686 chr19:29218302 NA 0.57 10.93 0.4 1.36e-25 Methadone dose in opioid dependence; BRCA cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg17330251 chr7:94953956 PON1 -0.42 -9.0 -0.34 2.53e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7267979 0.966 rs2261785 chr20:25262403 C/T cg08601574 chr20:25228251 PYGB 0.36 8.73 0.33 2.23e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg08888203 chr3:10149979 C3orf24 0.57 10.66 0.39 1.5e-24 Alzheimer's disease; BRCA cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg16586182 chr3:47516702 SCAP -0.56 -12.47 -0.44 4.1e-32 Colorectal cancer; BRCA cis rs4363385 0.740 rs1338181 chr1:153010301 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.17 -0.34 6.49e-19 Inflammatory skin disease; BRCA cis rs36051895 0.664 rs11788834 chr9:5092466 G/A cg02405213 chr9:5042618 JAK2 -0.51 -9.19 -0.34 5.31e-19 Pediatric autoimmune diseases; BRCA cis rs10911363 0.592 rs10797886 chr1:183479090 T/C cg09173681 chr1:183549694 NCF2 0.49 10.71 0.39 9.9e-25 Systemic lupus erythematosus; BRCA cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg13770153 chr20:60521292 NA -0.39 -9.39 -0.35 1.08e-19 Body mass index; BRCA cis rs7633770 0.664 rs11130101 chr3:46685895 T/A cg11219411 chr3:46661640 NA -0.51 -12.02 -0.43 3.69e-30 Coronary artery disease; BRCA cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg01475377 chr6:109611718 NA -0.51 -13.04 -0.46 1.3e-34 Reticulocyte fraction of red cells; BRCA cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.17 -0.37 1.31e-22 Initial pursuit acceleration; BRCA cis rs7582180 0.764 rs12615466 chr2:100924065 C/A cg14675211 chr2:100938903 LONRF2 0.49 11.19 0.4 1.12e-26 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg16586182 chr3:47516702 SCAP -0.6 -13.94 -0.48 9.4e-39 Colorectal cancer; BRCA cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg22676075 chr6:135203613 NA 0.44 8.64 0.32 4.4e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg17985854 chr11:65770987 BANF1;EIF1AD -0.35 -8.14 -0.31 2.04e-15 Eosinophil percentage of white cells; BRCA cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg23888215 chr10:79422304 NA -0.6 -11.3 -0.41 3.93e-27 Bone mineral density; BRCA cis rs7727544 0.735 rs272879 chr5:131670546 C/G cg07395648 chr5:131743802 NA -0.36 -9.08 -0.34 1.32e-18 Blood metabolite levels; BRCA cis rs9815354 0.812 rs56290987 chr3:42004882 T/C cg03022575 chr3:42003672 ULK4 0.74 10.27 0.38 5.43e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs3771570 1.000 rs62193208 chr2:242322430 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.18 0.34 5.69e-19 Prostate cancer; BRCA cis rs478304 0.651 rs4930313 chr11:65500428 C/T cg10518572 chr11:65560635 OVOL1 -0.28 -8.13 -0.31 2.19e-15 Acne (severe); BRCA cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg08704250 chr15:31115839 NA -0.34 -8.62 -0.32 5.15e-17 Huntington's disease progression; BRCA cis rs3008870 0.755 rs2815381 chr1:67514591 G/A cg02640540 chr1:67518911 SLC35D1 0.52 11.45 0.41 9.86e-28 Lymphocyte percentage of white cells; BRCA cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg00677455 chr12:58241039 CTDSP2 -0.35 -8.02 -0.3 5e-15 Celiac disease or Rheumatoid arthritis; BRCA cis rs78456975 0.527 rs11886696 chr2:1567841 A/G cg12573674 chr2:1569213 NA -0.61 -13.32 -0.47 6.5e-36 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2070488 0.775 rs1073506 chr3:38566235 G/T cg24069376 chr3:38537580 EXOG -0.31 -8.69 -0.33 2.93e-17 Electrocardiographic conduction measures; BRCA cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg11663144 chr21:46675770 NA -0.62 -14.09 -0.49 1.86e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4690686 0.538 rs11730551 chr4:177259182 A/G cg17059388 chr4:177262070 NA 0.49 9.93 0.37 1.07e-21 Essential tremor; BRCA cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.26 8.62 0.32 5.23e-17 Electroencephalogram traits; BRCA cis rs2204008 0.571 rs1117803 chr12:38281007 C/G cg26384229 chr12:38710491 ALG10B -0.44 -10.03 -0.37 4.37e-22 Bladder cancer; BRCA cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg21535247 chr6:8435926 SLC35B3 0.4 8.97 0.33 3.13e-18 Motion sickness; BRCA trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg20587970 chr11:113659929 NA -0.94 -13.85 -0.48 2.34e-38 Hip circumference adjusted for BMI; BRCA cis rs8028182 0.525 rs9920028 chr15:75927717 G/A cg20655648 chr15:75932815 IMP3 0.48 9.3 0.35 2.24e-19 Sudden cardiac arrest; BRCA cis rs17270561 0.636 rs10946793 chr6:25699999 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 8.96 0.33 3.47e-18 Iron status biomarkers; BRCA cis rs910316 0.935 rs175422 chr14:75627319 T/A cg23033748 chr14:75592666 NEK9 -0.43 -10.46 -0.38 9.28e-24 Height; BRCA cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.63 -0.39 2e-24 Schizophrenia; BRCA cis rs6028335 0.610 rs67621213 chr20:37582553 G/A cg16355469 chr20:37678765 NA 0.43 7.84 0.3 1.96e-14 Alcohol and nicotine co-dependence; BRCA cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg08564027 chr20:61660810 NA -0.76 -20.12 -0.62 4.25e-70 Prostate cancer (SNP x SNP interaction); BRCA cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.24 0.44 4.33e-31 Mean platelet volume; BRCA cis rs8177253 0.763 rs6797713 chr3:133474832 T/C cg11941060 chr3:133502564 NA -0.38 -8.62 -0.32 5.37e-17 Iron status biomarkers; BRCA cis rs514406 0.893 rs476108 chr1:53317351 C/T cg08859206 chr1:53392774 SCP2 -0.51 -11.23 -0.41 7.8e-27 Monocyte count; BRCA cis rs9790314 1.000 rs336577 chr3:161066294 C/T cg04691961 chr3:161091175 C3orf57 -0.6 -14.51 -0.5 1.84e-41 Morning vs. evening chronotype; BRCA cis rs17685 0.753 rs6953665 chr7:75769049 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg05044414 chr3:183734942 ABCC5 -0.4 -7.83 -0.3 2.01e-14 Anterior chamber depth; BRCA cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.8 0.42 3.4e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6860806 0.507 rs273917 chr5:131659618 A/G cg24060327 chr5:131705240 SLC22A5 -0.61 -11.54 -0.42 4.26e-28 Breast cancer; BRCA cis rs6598955 0.543 rs60433268 chr1:26548055 A/C cg12744634 chr1:26560303 CCDC21 0.3 7.99 0.3 6.34e-15 Obesity-related traits; BRCA cis rs208520 0.955 rs28684412 chr6:66979430 A/C cg07460842 chr6:66804631 NA 0.87 14.18 0.49 6.74e-40 Exhaled nitric oxide output; BRCA cis rs7481584 0.624 rs428726 chr11:3046201 G/A cg08508325 chr11:3079039 CARS 0.28 8.51 0.32 1.24e-16 Calcium levels; BRCA cis rs4363385 0.747 rs6671524 chr1:152974247 C/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.29 -0.31 6.67e-16 Inflammatory skin disease; BRCA cis rs66887589 0.616 rs7659403 chr4:120207254 T/A cg09307838 chr4:120376055 NA 0.46 9.58 0.35 2.03e-20 Diastolic blood pressure; BRCA cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg08917208 chr2:24149416 ATAD2B 0.93 13.77 0.48 6.03e-38 Lymphocyte counts; BRCA cis rs7809950 0.723 rs62483634 chr7:106878516 G/A cg23024343 chr7:107201750 COG5 -0.42 -9.24 -0.34 3.61e-19 Coronary artery disease; BRCA cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg18876405 chr7:65276391 NA 0.7 18.44 0.59 3.37e-61 Calcium levels; BRCA trans rs9291683 0.609 rs12500810 chr4:10031068 G/A cg26043149 chr18:55253948 FECH 0.41 8.93 0.33 4.33e-18 Bone mineral density; BRCA cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg11247378 chr22:39784982 NA -0.61 -14.19 -0.49 6.56e-40 Intelligence (multi-trait analysis); BRCA cis rs9359856 0.564 rs72915944 chr6:90447226 C/T cg13799429 chr6:90582589 CASP8AP2 -0.67 -8.39 -0.31 3.13e-16 Bipolar disorder; BRCA cis rs3796352 1.000 rs11717619 chr3:53003179 A/C cg07884673 chr3:53033167 SFMBT1 0.68 8.76 0.33 1.71e-17 Immune reponse to smallpox (secreted IL-2); BRCA cis rs10464366 0.912 rs6979668 chr7:39104228 G/A cg18850127 chr7:39170497 POU6F2 0.39 8.26 0.31 8.58e-16 IgG glycosylation; BRCA cis rs9790314 0.747 rs1599378 chr3:160874511 A/C cg04691961 chr3:161091175 C3orf57 -0.41 -9.18 -0.34 5.84e-19 Morning vs. evening chronotype; BRCA cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg24088639 chr11:34937564 PDHX;APIP -0.4 -9.03 -0.34 2.08e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7246657 0.765 rs4803262 chr19:38066760 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.57 -0.45 1.5e-32 Bipolar disorder; BRCA cis rs6723226 0.698 rs13409142 chr2:32666137 C/T cg02381751 chr2:32503542 YIPF4 0.69 15.33 0.52 2.09e-45 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.810 rs2275252 chr13:44454374 A/C cg17145862 chr1:211918768 LPGAT1 0.69 17.46 0.57 3.96e-56 Leprosy; BRCA cis rs3771570 1.000 rs59496049 chr2:242260756 G/C cg21155796 chr2:242212141 HDLBP 0.53 8.96 0.33 3.67e-18 Prostate cancer; BRCA cis rs6586163 0.527 rs3740286 chr10:90751340 A/G cg03111039 chr10:90751583 FAS;ACTA2 0.57 13.05 0.46 1.08e-34 Chronic lymphocytic leukemia; BRCA cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg00071950 chr4:10020882 SLC2A9 0.66 16.64 0.55 6.69e-52 Bone mineral density; BRCA cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg18016565 chr1:150552671 MCL1 -0.38 -8.68 -0.32 3.29e-17 Tonsillectomy; BRCA cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15084286 chr11:17036142 PLEKHA7 0.88 23.93 0.69 7.91e-91 Coronary artery disease; BRCA cis rs2421770 0.530 rs3858470 chr11:35365444 T/C cg13971030 chr11:35366721 SLC1A2 -0.45 -10.12 -0.37 1.94e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs2303759 0.676 rs7248378 chr19:49908144 C/A cg22590775 chr19:49891494 CCDC155 0.44 8.04 0.3 4.39e-15 Multiple sclerosis; BRCA trans rs4596713 0.568 rs7034303 chr9:71746871 A/G cg16512924 chr15:28394682 HERC2 -0.39 -9.53 -0.35 3.1e-20 Headache; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.61 -11.79 -0.42 3.66e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg08109568 chr15:31115862 NA -0.42 -9.98 -0.37 6.72e-22 Huntington's disease progression; BRCA cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg11890956 chr21:40555474 PSMG1 -0.83 -20.37 -0.63 1.78e-71 Cognitive function; BRCA trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.89 -0.3 1.33e-14 Corneal astigmatism; BRCA cis rs7524258 0.868 rs4243824 chr1:7289777 G/A cg07173049 chr1:7289937 CAMTA1 0.51 12.43 0.44 6.32e-32 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs61931739 0.500 rs11053251 chr12:34520743 A/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.3e-22 Morning vs. evening chronotype; BRCA cis rs6430585 0.583 rs59243420 chr2:136584538 A/T cg07169764 chr2:136633963 MCM6 1.32 32.9 0.79 1.21e-139 Corneal structure; BRCA cis rs11025559 0.812 rs16906280 chr11:20472242 T/C cg19653624 chr11:20408972 PRMT3 -0.44 -10.06 -0.37 3.48e-22 Pursuit maintenance gain; BRCA cis rs5167 0.504 rs892101 chr19:45455458 G/A cg09555818 chr19:45449301 APOC2 0.47 12.17 0.43 8.55e-31 Blood protein levels; BRCA cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg24549020 chr5:56110836 MAP3K1 0.62 11.57 0.42 2.97e-28 Initial pursuit acceleration; BRCA cis rs2645694 0.651 rs2703128 chr4:77819187 C/G cg06046430 chr4:77819534 ANKRD56 0.58 13.04 0.46 1.28e-34 Emphysema distribution in smoking; BRCA cis rs9462027 0.651 rs6940395 chr6:34736553 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.93 -0.3 9.96e-15 Systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs13110498 chr4:98959150 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs4650994 0.505 rs2811291 chr1:178574217 C/T cg05059571 chr16:84539110 KIAA1609 0.57 12.49 0.44 3.53e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs13136331 0.680 rs2732206 chr4:88652504 T/A cg12990093 chr4:88570587 DMP1 -0.39 -8.06 -0.3 3.9e-15 Sitting height ratio; BRCA cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg25358565 chr5:93447407 FAM172A 1.23 19.52 0.61 6.5e-67 Diabetic retinopathy; BRCA cis rs7582180 0.764 rs13001423 chr2:100925340 A/G cg14675211 chr2:100938903 LONRF2 0.49 11.18 0.4 1.22e-26 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 19.98 0.62 2.34e-69 Platelet count; BRCA cis rs2282802 0.685 rs6889283 chr5:139653439 G/T cg26211634 chr5:139558579 C5orf32 0.35 8.37 0.31 3.61e-16 Intelligence (multi-trait analysis); BRCA cis rs4911259 0.513 rs6057665 chr20:31463460 A/G cg13636640 chr20:31349939 DNMT3B -0.45 -11.89 -0.43 1.36e-29 Inflammatory bowel disease; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg16606324 chr3:10149918 C3orf24 -0.57 -11.23 -0.41 7.83e-27 Alzheimer's disease; BRCA cis rs9549328 0.756 rs2993291 chr13:113653846 C/T cg01248385 chr13:113636953 MCF2L -0.41 -8.2 -0.31 1.27e-15 Systolic blood pressure; BRCA cis rs2749592 0.918 rs1208653 chr10:38253826 C/G cg25427524 chr10:38739819 LOC399744 0.61 11.84 0.42 2.27e-29 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg24397884 chr7:158709396 WDR60 0.69 15.1 0.51 2.7e-44 Height; BRCA cis rs875971 0.617 rs810400 chr7:66022889 G/C cg11764359 chr7:65958608 NA -0.68 -15.19 -0.52 9.74e-45 Aortic root size; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg22907277 chr7:1156413 C7orf50 0.59 9.1 0.34 1.11e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2749592 0.513 rs1208708 chr10:38085576 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -9.43 -0.35 7.62e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg00684032 chr4:1343700 KIAA1530 0.4 9.79 0.36 3.4e-21 Obesity-related traits; BRCA cis rs67460515 0.892 rs4856757 chr3:160999418 A/T cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Parkinson's disease; BRCA cis rs2991971 0.967 rs10789465 chr1:45971759 T/C cg24296786 chr1:45957014 TESK2 0.63 15.75 0.53 1.72e-47 High light scatter reticulocyte count; BRCA cis rs17270561 0.609 rs9358872 chr6:25727517 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs13082711 0.871 rs13061912 chr3:27495586 A/G cg02860705 chr3:27208620 NA 0.53 10.56 0.39 3.86e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7666738 0.606 rs4577589 chr4:99087858 A/G cg05340658 chr4:99064831 C4orf37 0.48 10.6 0.39 2.77e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs8170 0.603 rs7249329 chr19:17423373 G/T cg02455703 chr19:17412272 ABHD8 -0.35 -7.91 -0.3 1.12e-14 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs4730250 0.655 rs4727671 chr7:106876045 A/G cg02696742 chr7:106810147 HBP1 -0.47 -7.89 -0.3 1.3e-14 Osteoarthritis; BRCA cis rs7255436 0.965 rs7249624 chr19:8446135 G/A cg10174797 chr19:8464628 RAB11B 0.35 8.91 0.33 5.31e-18 HDL cholesterol; BRCA trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg15704280 chr7:45808275 SEPT13 -0.79 -18.55 -0.59 9e-62 Coronary artery disease; BRCA cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg23033748 chr14:75592666 NEK9 0.4 9.35 0.35 1.42e-19 Height; BRCA cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg02475777 chr4:1388615 CRIPAK -0.51 -10.03 -0.37 4.45e-22 Obesity-related traits; BRCA cis rs78456975 0.943 rs13385274 chr2:1576791 A/T cg12573674 chr2:1569213 NA -0.42 -8.1 -0.31 2.84e-15 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs17270561 0.609 rs4712961 chr6:25727334 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs3768617 0.510 rs35968946 chr1:183114871 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 16.77 0.55 1.34e-52 Fuchs's corneal dystrophy; BRCA cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg06550200 chr5:1325588 CLPTM1L -0.65 -14.14 -0.49 1.06e-39 Lung cancer; BRCA trans rs9325144 0.555 rs2387855 chr12:38687964 T/G cg23762105 chr12:34175262 ALG10 -0.36 -9.03 -0.34 2.06e-18 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg04944784 chr2:26401820 FAM59B -0.84 -13.14 -0.46 4.37e-35 Gut microbiome composition (summer); BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.48 -8.42 -0.32 2.41e-16 Renal function-related traits (BUN); BRCA trans rs526821 0.595 rs565859 chr11:55297367 T/C cg11707556 chr5:10655725 ANKRD33B -0.37 -8.19 -0.31 1.47e-15 Pediatric bone mineral density (spine); BRCA cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg16586182 chr3:47516702 SCAP -0.56 -12.9 -0.45 5.53e-34 Colorectal cancer; BRCA trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg06636001 chr8:8085503 FLJ10661 -0.52 -11.77 -0.42 4.19e-29 Systolic blood pressure; BRCA trans rs6089829 0.962 rs6089826 chr20:61668595 G/A cg17470723 chr8:74884337 TCEB1 0.4 8.67 0.32 3.6e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6964587 0.869 rs2374519 chr7:91541481 T/C cg17063962 chr7:91808500 NA -0.51 -11.93 -0.43 8.99e-30 Breast cancer; BRCA cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg03264133 chr6:25882463 NA -0.54 -12.21 -0.43 5.71e-31 Blood metabolite levels; BRCA cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg27446573 chr6:127587934 RNF146 0.9 21.32 0.64 1.39e-76 Breast cancer; BRCA cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg04546413 chr19:29218101 NA 0.62 10.42 0.38 1.34e-23 Methadone dose in opioid dependence; BRCA cis rs9790314 1.000 rs336577 chr3:161066294 C/T cg03342759 chr3:160939853 NMD3 -0.63 -13.55 -0.47 5.9e-37 Morning vs. evening chronotype; BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 18.6 0.59 4.7e-62 Platelet count; BRCA cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg18404041 chr3:52824283 ITIH1 -0.39 -12.11 -0.43 1.49e-30 Bipolar disorder; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 18.71 0.59 1.32e-62 Alzheimer's disease; BRCA cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg22862634 chr11:62369728 EML3;MTA2 0.55 13.59 0.47 4e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg18765753 chr7:1198926 ZFAND2A -0.46 -10.62 -0.39 2.2e-24 Longevity;Endometriosis; BRCA cis rs9560113 0.509 rs4771759 chr13:112209217 A/G cg10483660 chr13:112241077 NA -0.37 -10.68 -0.39 1.29e-24 Menarche (age at onset); BRCA trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg15556689 chr8:8085844 FLJ10661 -0.34 -8.97 -0.33 3.32e-18 Neuroticism; BRCA cis rs9790314 0.581 rs6806054 chr3:160724978 C/T cg03342759 chr3:160939853 NMD3 -0.44 -9.13 -0.34 8.97e-19 Morning vs. evening chronotype; BRCA cis rs6835098 1.000 rs10031414 chr4:174084953 A/C cg08422745 chr4:174089978 GALNT7 -0.81 -18.47 -0.59 2.37e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7188861 0.768 rs430966 chr16:11389482 C/T cg01510278 chr16:11456238 NA 0.43 8.29 0.31 6.63e-16 HDL cholesterol; BRCA cis rs4363385 0.747 rs1577963 chr1:152961882 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.68 -0.32 3.27e-17 Inflammatory skin disease; BRCA cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg25237894 chr2:233734115 C2orf82 -0.38 -11.18 -0.4 1.21e-26 Coronary artery disease; BRCA cis rs7512552 0.839 rs1498308 chr1:150295131 G/T cg15654264 chr1:150340011 RPRD2 0.37 8.4 0.32 2.78e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA trans rs61931739 0.534 rs2667447 chr12:34133468 C/A cg13010199 chr12:38710504 ALG10B 0.39 8.1 0.31 2.69e-15 Morning vs. evening chronotype; BRCA trans rs6479891 1.000 rs4469774 chr10:65309777 G/T cg14819942 chr15:35414228 NA 0.35 8.47 0.32 1.74e-16 Arthritis (juvenile idiopathic); BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg00106254 chr7:1943704 MAD1L1 0.39 9.61 0.36 1.6e-20 Bipolar disorder and schizophrenia; BRCA cis rs4363385 0.818 rs426360 chr1:153014710 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.28e-14 Inflammatory skin disease; BRCA cis rs2354432 0.556 rs7520661 chr1:146793149 A/G cg25205988 chr1:146714368 CHD1L -0.82 -11.24 -0.41 7.1e-27 Mitochondrial DNA levels; BRCA cis rs28374715 0.783 rs11630656 chr15:41570909 T/G cg18705301 chr15:41695430 NDUFAF1 -1.03 -21.13 -0.64 1.44e-75 Ulcerative colitis; BRCA trans rs2204008 0.846 rs2030416 chr12:38465118 A/G cg06521331 chr12:34319734 NA 0.46 9.19 0.34 5.52e-19 Bladder cancer; BRCA trans rs9291683 0.538 rs11727199 chr4:10036190 C/T cg26043149 chr18:55253948 FECH 0.42 9.12 0.34 9.57e-19 Bone mineral density; BRCA cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg10621924 chr7:39171070 POU6F2 0.39 7.97 0.3 7.16e-15 IgG glycosylation; BRCA cis rs4803468 1.000 rs17318666 chr19:41940342 T/G cg09537434 chr19:41945824 ATP5SL 1.02 23.92 0.69 8.77e-91 Height; BRCA cis rs6987853 0.749 rs13250124 chr8:42404737 G/A cg09913449 chr8:42400586 C8orf40 0.42 9.36 0.35 1.35e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs654950 0.875 rs586055 chr1:41999076 T/C cg06885757 chr1:42089581 HIVEP3 0.23 7.89 0.3 1.32e-14 Airway imaging phenotypes; BRCA cis rs911555 0.723 rs11160751 chr14:103925740 T/C cg24130564 chr14:104152367 KLC1 -0.4 -9.03 -0.34 1.95e-18 Intelligence (multi-trait analysis); BRCA trans rs561341 0.943 rs508566 chr17:30289861 G/C cg20587970 chr11:113659929 NA -1.19 -21.49 -0.65 1.61e-77 Hip circumference adjusted for BMI; BRCA trans rs11976180 1.000 rs1919950 chr7:143767898 T/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.2 -0.31 1.32e-15 Obesity-related traits; BRCA cis rs4730250 0.707 rs4730222 chr7:106810293 G/C cg02696742 chr7:106810147 HBP1 -0.6 -9.44 -0.35 6.58e-20 Osteoarthritis; BRCA cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg23262073 chr20:60523788 NA -0.4 -8.7 -0.33 2.71e-17 Body mass index; BRCA cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg01819863 chr10:32635814 EPC1 1.21 20.81 0.64 8.38e-74 Sexual dysfunction (female); BRCA cis rs1568889 0.838 rs11030220 chr11:28145769 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 20.15 0.62 2.8e-70 Bipolar disorder; BRCA cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg07917127 chr4:99064746 C4orf37 0.43 8.0 0.3 5.74e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.62e-22 Bladder cancer; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg15112475 chr7:1198522 ZFAND2A -0.45 -9.94 -0.37 9.37e-22 Longevity;Endometriosis; BRCA cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg26031613 chr14:104095156 KLC1 0.65 14.3 0.49 1.91e-40 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg03146154 chr1:46216737 IPP 0.51 11.39 0.41 1.65e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.84 0.36 2.36e-21 Bipolar disorder; BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.03 0.3 4.62e-15 Tonsillectomy; BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg04267008 chr7:1944627 MAD1L1 -0.65 -13.68 -0.48 1.49e-37 Bipolar disorder and schizophrenia; BRCA cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg13119609 chr19:45449297 APOC2 0.46 12.98 0.46 2.24e-34 Blood protein levels; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg09177884 chr7:1199841 ZFAND2A -0.41 -8.75 -0.33 1.87e-17 Longevity;Endometriosis; BRCA cis rs6866344 0.697 rs17184344 chr5:178129281 A/G cg03877680 chr5:178157825 ZNF354A 0.79 14.61 0.5 6.69e-42 Neutrophil percentage of white cells; BRCA trans rs61931739 0.517 rs1844525 chr12:34103183 T/A cg26384229 chr12:38710491 ALG10B 0.68 14.16 0.49 8.91e-40 Morning vs. evening chronotype; BRCA cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg18876405 chr7:65276391 NA 0.43 8.68 0.32 3.2e-17 Corneal structure; BRCA cis rs68170813 0.559 rs75723759 chr7:106962407 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.58 -0.32 6.93e-17 Coronary artery disease; BRCA cis rs11874712 1.000 rs13381709 chr18:43670988 C/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA trans rs11227306 0.934 rs11227313 chr11:65588938 C/T cg17712092 chr4:129076599 LARP1B 0.42 8.61 0.32 5.5e-17 DNA methylation (variation); BRCA cis rs12142240 0.698 rs6703669 chr1:46862555 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg03934865 chr2:198174659 NA -0.39 -8.38 -0.31 3.34e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4481887 0.927 rs4244173 chr1:248466899 G/C cg00666640 chr1:248458726 OR2T12 0.33 8.84 0.33 9.49e-18 Common traits (Other); BRCA cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg24006582 chr15:45444508 DUOX1 -0.56 -11.58 -0.42 2.72e-28 Uric acid levels; BRCA trans rs6089829 0.962 rs1116450 chr20:61658210 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.6 0.32 6.17e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6694270 0.529 rs35941610 chr1:19104930 C/T cg26220594 chr1:19110978 NA -0.44 -7.98 -0.3 6.76e-15 Drug-induced liver injury (nitrofurantoin); BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.42e-19 Tonsillectomy; BRCA cis rs28830936 1.000 rs17676742 chr15:41903048 A/G cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.28 -0.34 2.65e-19 Diastolic blood pressure; BRCA cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg02297831 chr4:17616191 MED28 -0.37 -8.35 -0.31 4.21e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11711311 1.000 rs11711311 chr3:113430599 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.65 -0.36 1.15e-20 IgG glycosylation; BRCA cis rs4268898 0.722 rs35520052 chr2:24415277 C/T cg06627628 chr2:24431161 ITSN2 0.46 9.57 0.35 2.26e-20 Asthma; BRCA cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg17366294 chr4:99064904 C4orf37 0.46 8.31 0.31 5.87e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs12950390 0.853 rs11079792 chr17:45863311 T/C cg24803719 chr17:45855879 NA -0.3 -7.84 -0.3 1.88e-14 IgG glycosylation; BRCA cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg22974920 chr21:40686053 BRWD1 -0.41 -9.07 -0.34 1.47e-18 Cognitive function; BRCA cis rs7949030 1.000 rs10897289 chr11:62400016 T/C cg13298116 chr11:62369859 EML3;MTA2 0.42 9.77 0.36 4.21e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs765787 0.530 rs2554454 chr15:45521536 A/G cg24006582 chr15:45444508 DUOX1 -0.51 -10.65 -0.39 1.75e-24 Uric acid levels; BRCA cis rs3806843 0.966 rs2563261 chr5:140137713 G/T cg16179182 chr5:140090404 VTRNA1-1 0.43 10.01 0.37 5.03e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg18402987 chr7:1209562 NA 0.39 7.83 0.3 1.97e-14 Longevity;Endometriosis; BRCA cis rs9290065 0.519 rs9857743 chr3:160677732 G/A cg03342759 chr3:160939853 NMD3 -0.5 -10.26 -0.38 5.91e-23 Kawasaki disease; BRCA cis rs11676348 0.846 rs7607437 chr2:219008392 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.41 -8.41 -0.32 2.63e-16 Ulcerative colitis; BRCA cis rs6088590 0.931 rs12625149 chr20:33425812 A/C cg06115741 chr20:33292138 TP53INP2 -0.46 -9.57 -0.35 2.38e-20 Coronary artery disease; BRCA trans rs11722228 0.508 rs3756227 chr4:10087995 C/A cg26043149 chr18:55253948 FECH 0.97 21.16 0.64 1.08e-75 Gout;Urate levels;Serum uric acid levels; BRCA cis rs1005277 0.505 rs719569 chr10:38154415 T/G cg00409905 chr10:38381863 ZNF37A 0.49 10.48 0.38 7.75e-24 Extrinsic epigenetic age acceleration; BRCA cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.54 11.2 0.41 1e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9486719 0.857 rs2971609 chr6:97039665 A/G cg06623918 chr6:96969491 KIAA0776 -0.75 -16.78 -0.55 1.31e-52 Migraine;Coronary artery disease; BRCA cis rs11229555 0.645 rs34530191 chr11:58200854 A/G cg15696309 chr11:58395628 NA -0.52 -10.83 -0.39 3.19e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg18402987 chr7:1209562 NA 0.45 8.58 0.32 7.29e-17 Longevity;Endometriosis; BRCA cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg01884057 chr2:25150051 NA 0.34 9.16 0.34 7.08e-19 Body mass index; BRCA cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg08109568 chr15:31115862 NA -0.59 -14.04 -0.49 3.24e-39 Huntington's disease progression; BRCA cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg18446336 chr7:2847575 GNA12 -0.42 -10.66 -0.39 1.61e-24 Height; BRCA cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA trans rs35110281 0.667 rs2838354 chr21:45119857 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.04 0.3 4.39e-15 Mean corpuscular volume; BRCA cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg00071950 chr4:10020882 SLC2A9 0.66 16.72 0.55 2.39e-52 Bone mineral density; BRCA cis rs28830936 0.625 rs8038764 chr15:41907905 A/C cg17847044 chr15:42102381 MAPKBP1 0.46 16.5 0.55 3.18e-51 Diastolic blood pressure; BRCA cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg12386194 chr3:101231763 SENP7 0.46 9.91 0.36 1.29e-21 Colorectal cancer; BRCA cis rs1865760 0.929 rs1436307 chr6:25939723 C/T cg16482183 chr6:26056742 HIST1H1C 0.5 10.26 0.38 5.87e-23 Height; BRCA cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg19077165 chr18:44547161 KATNAL2 -0.51 -10.83 -0.39 3.21e-25 Personality dimensions; BRCA cis rs7809950 1.000 rs2712201 chr7:107145564 T/C cg23024343 chr7:107201750 COG5 -0.41 -9.43 -0.35 7.5599999999999994e-20 Coronary artery disease; BRCA cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg00012203 chr2:219082015 ARPC2 0.46 9.05 0.34 1.76e-18 Colorectal cancer; BRCA cis rs7582180 0.627 rs6542947 chr2:100999647 C/G cg14675211 chr2:100938903 LONRF2 -0.4 -8.93 -0.33 4.41e-18 Intelligence (multi-trait analysis); BRCA cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.32 -0.38 3.23e-23 Psoriasis; BRCA cis rs2629540 0.847 rs12763093 chr10:126395688 C/G cg08799069 chr10:126477246 METTL10 -0.46 -9.28 -0.34 2.56e-19 Cocaine dependence; BRCA cis rs7914558 1.000 rs10509757 chr10:104752960 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.73 0.39 8.22e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs11984145 0.614 rs11972387 chr7:38836970 C/A cg19327137 chr7:38886074 VPS41 0.48 8.79 0.33 1.41e-17 Cognitive performance; BRCA trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg18944383 chr4:111397179 ENPEP -0.35 -7.91 -0.3 1.16e-14 Height; BRCA trans rs60843830 0.661 rs55987018 chr2:106655 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.48 9.36 0.35 1.35e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg11764359 chr7:65958608 NA 0.68 15.14 0.51 1.77e-44 Aortic root size; BRCA trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg23533926 chr12:111358616 MYL2 -0.42 -8.84 -0.33 9.21e-18 Extrinsic epigenetic age acceleration; BRCA cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg18876405 chr7:65276391 NA 0.52 12.19 0.43 7e-31 Aortic root size; BRCA cis rs6942756 0.758 rs13226649 chr7:128977598 C/T cg02491457 chr7:128862824 NA -0.57 -12.08 -0.43 2.11e-30 White matter hyperintensity burden; BRCA cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg04450456 chr4:17643702 FAM184B 0.31 9.07 0.34 1.4e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs511515 1 rs511515 chr6:33541507 A/G cg24505687 chr6:33548425 BAK1 0.56 12.15 0.43 1.09e-30 Eosinophil counts;Sum eosinophil basophil counts;Eosinophil percentage of white cells; BRCA cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg20476274 chr7:133979776 SLC35B4 0.67 19.75 0.62 4.09e-68 Mean platelet volume; BRCA cis rs9467711 0.651 rs2237228 chr6:26104630 C/T cg21479132 chr6:26055353 NA 0.59 7.93 0.3 9.92e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs2652834 0.950 rs2729787 chr15:63401493 G/T cg05507819 chr15:63340323 TPM1 0.44 7.96 0.3 8.07e-15 HDL cholesterol; BRCA cis rs1595825 0.891 rs7580003 chr2:198517893 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -8.23 -0.31 1.03e-15 Ulcerative colitis; BRCA cis rs1577917 0.837 rs10944157 chr6:86577199 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -11.05 -0.4 4.09e-26 Response to antipsychotic treatment; BRCA cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg03433033 chr1:76189801 ACADM 0.75 17.32 0.57 2.23e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg13010199 chr12:38710504 ALG10B 0.48 9.33 0.35 1.76e-19 Bladder cancer; BRCA cis rs7264396 0.563 rs2425088 chr20:34303902 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.05e-30 Total cholesterol levels; BRCA cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.42 0.61 2.12e-66 Cognitive function; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.57 10.46 0.38 9.52e-24 Gut microbiome composition (summer); BRCA trans rs35110281 0.720 rs162376 chr21:44926759 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.49 -10.27 -0.38 5.4e-23 Mean corpuscular volume; BRCA cis rs4363385 0.747 rs1415970 chr1:152965741 G/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.49 -0.32 1.42e-16 Inflammatory skin disease; BRCA cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg24562669 chr7:97807699 LMTK2 0.47 12.51 0.44 2.76e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs6684514 1.000 rs28372828 chr1:156253031 G/C cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs28374715 0.532 rs3204853 chr15:41689166 C/A cg18705301 chr15:41695430 NDUFAF1 -1.09 -25.42 -0.71 4.97e-99 Ulcerative colitis; BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs9381107 0.932 rs2103674 chr6:9451701 G/A cg14735645 chr6:9486422 NA -0.45 -7.92 -0.3 1.09e-14 Nonsyndromic cleft lip with cleft palate; BRCA cis rs7395581 0.775 rs2269434 chr11:47360412 T/C cg25783544 chr11:47291846 MADD 0.37 8.29 0.31 6.66e-16 HDL cholesterol; BRCA trans rs6582630 0.502 rs10880092 chr12:38262965 A/T cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs514406 0.505 rs427319 chr1:53178807 T/G cg08859206 chr1:53392774 SCP2 -0.42 -8.54 -0.32 9.56e-17 Monocyte count; BRCA cis rs10754283 0.967 rs4658302 chr1:90103336 A/G cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1801251 1.000 rs283471 chr2:233656627 G/A cg25237894 chr2:233734115 C2orf82 0.39 10.96 0.4 1.03e-25 Coronary artery disease; BRCA cis rs858239 0.932 rs858275 chr7:23294144 T/C cg23682824 chr7:23144976 KLHL7 0.33 8.49 0.32 1.42e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs1371614 0.632 rs6707735 chr2:27166822 T/C cg00617064 chr2:27272375 NA -0.32 -8.41 -0.32 2.73e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4664304 0.620 rs10929956 chr2:160714615 C/T cg02280532 chr2:160761244 LY75 0.35 7.85 0.3 1.78e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1568889 0.774 rs11030235 chr11:28212375 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.37 0.63 1.82e-71 Bipolar disorder; BRCA cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg27478167 chr7:817139 HEATR2 0.53 9.65 0.36 1.13e-20 Cerebrospinal P-tau181p levels; BRCA cis rs16866061 1.000 rs72974203 chr2:225408430 G/A cg12698349 chr2:225449008 CUL3 0.78 21.22 0.64 4.75e-76 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs6545883 0.801 rs778142 chr2:61681428 G/T cg15711740 chr2:61764176 XPO1 -0.52 -12.51 -0.44 2.8e-32 Tuberculosis; BRCA cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg11279151 chr3:101281821 RG9MTD1 -0.51 -10.49 -0.38 7.01e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs8028313 0.630 rs3784700 chr15:68017752 A/G cg05925327 chr15:68127851 NA -0.37 -8.01 -0.3 5.37e-15 Obesity; BRCA cis rs6684428 1.000 rs12145137 chr1:56370557 A/T cg11651538 chr1:56320950 NA -0.46 -7.81 -0.3 2.32e-14 Airflow obstruction; BRCA cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg16339924 chr4:17578868 LAP3 0.58 13.68 0.48 1.48e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4713118 0.513 rs9368547 chr6:28028067 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.9 0.3 1.25e-14 Parkinson's disease; BRCA cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg00684032 chr4:1343700 KIAA1530 0.53 12.44 0.44 5.61e-32 Obesity-related traits; BRCA cis rs72781680 0.848 rs72780199 chr2:24016269 A/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA trans rs6952808 0.501 rs4721429 chr7:2171704 T/C cg04565464 chr8:145669602 NFKBIL2 0.4 8.63 0.32 4.75e-17 Bipolar disorder and schizophrenia; BRCA cis rs1707322 1.000 rs785470 chr1:46519622 C/A cg06784218 chr1:46089804 CCDC17 -0.45 -10.84 -0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9359856 0.510 rs2768940 chr6:90436319 A/G cg13799429 chr6:90582589 CASP8AP2 -0.68 -10.78 -0.39 5.02e-25 Bipolar disorder; BRCA cis rs1003719 0.751 rs10154032 chr21:38453459 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.07 0.49 2.27e-39 Eye color traits; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs3892630 0.500 rs6510301 chr19:33359791 A/T cg22980127 chr19:33182716 NUDT19 0.74 13.93 0.48 1.02e-38 Red blood cell traits; BRCA trans rs6952808 0.692 rs6950627 chr7:2086672 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 8.49 0.32 1.43e-16 Bipolar disorder and schizophrenia; BRCA cis rs4363385 0.747 rs9919227 chr1:152970867 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.22 -0.31 1.17e-15 Inflammatory skin disease; BRCA cis rs1215050 0.740 rs700739 chr4:99022546 A/G cg05340658 chr4:99064831 C4orf37 -0.5 -11.63 -0.42 1.75e-28 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9467711 0.651 rs13206443 chr6:26119245 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.58 8.37 0.31 3.69e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs2455799 0.533 rs2470550 chr3:15743721 C/T cg16303742 chr3:15540471 COLQ -0.35 -8.35 -0.31 4.09e-16 Mean platelet volume; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg25036284 chr2:26402008 FAM59B 0.7 12.36 0.44 1.35e-31 Gut microbiome composition (summer); BRCA cis rs9868809 0.505 rs28567949 chr3:48744560 G/A cg01304814 chr3:48885189 PRKAR2A 0.57 8.01 0.3 5.25e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg21395723 chr22:39101663 GTPBP1 0.4 8.62 0.32 5.08e-17 Menopause (age at onset); BRCA cis rs7666738 0.830 rs1593572 chr4:98979322 A/G cg03676636 chr4:99064102 C4orf37 -0.21 -8.2 -0.31 1.29e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.686 rs2991986 chr1:46081282 A/G cg03146154 chr1:46216737 IPP -0.49 -10.67 -0.39 1.45e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg00750074 chr16:89608354 SPG7 -0.41 -11.14 -0.4 1.84e-26 Multiple myeloma (IgH translocation); BRCA cis rs2070488 1.000 rs7433707 chr3:38443180 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.38 0.61 3.86e-66 Electrocardiographic conduction measures; BRCA cis rs3806843 1.000 rs13184940 chr5:140172918 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.8 -0.36 3.32e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg03709012 chr19:19516395 GATAD2A -0.75 -16.77 -0.55 1.34e-52 Tonsillectomy; BRCA cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg06552810 chr11:31128660 NA -0.4 -8.84 -0.33 9.43e-18 Bone mineral density (spine); BRCA cis rs12760731 0.720 rs12039605 chr1:178433368 C/T cg00404053 chr1:178313656 RASAL2 0.61 7.99 0.3 6.12e-15 Obesity-related traits; BRCA cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg06671706 chr8:8559999 CLDN23 0.44 8.51 0.32 1.27e-16 Obesity-related traits; BRCA cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.49 -9.71 -0.36 7.26e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg04727924 chr7:799746 HEATR2 -0.56 -10.11 -0.37 2.1e-22 Cerebrospinal P-tau181p levels; BRCA cis rs1691799 0.867 rs1168309 chr12:66726439 A/G cg16791601 chr12:66731901 HELB 0.68 19.3 0.61 1.02e-65 White blood cell count (basophil); BRCA cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg13770153 chr20:60521292 NA -0.45 -10.81 -0.39 4.09e-25 Body mass index; BRCA cis rs2730245 1.000 rs2657365 chr7:158722753 A/T cg24397884 chr7:158709396 WDR60 -0.95 -23.99 -0.69 3.74e-91 Height; BRCA cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.16 0.37 1.45e-22 Aortic root size; BRCA cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.84 -0.3 1.9e-14 Aortic root size; BRCA cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg11644478 chr21:40555479 PSMG1 -0.66 -14.28 -0.49 2.5e-40 Cognitive function; BRCA cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg25173405 chr17:45401733 C17orf57 0.49 9.96 0.37 8.04e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6582630 0.555 rs12372536 chr12:38400864 C/G cg13010199 chr12:38710504 ALG10B 0.5 10.3 0.38 4.14e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg16606324 chr3:10149918 C3orf24 0.56 11.15 0.4 1.74e-26 Alzheimer's disease; BRCA cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg13047869 chr3:10149882 C3orf24 0.53 11.33 0.41 2.9e-27 Alzheimer's disease; BRCA trans rs911555 0.723 rs7149767 chr14:103863545 G/A cg17675199 chr6:35436792 RPL10A -0.29 -8.0 -0.3 5.77e-15 Intelligence (multi-trait analysis); BRCA cis rs71636778 0.543 rs12749822 chr1:27221963 T/C cg12203394 chr1:27248618 NUDC 0.61 9.53 0.35 3.3e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.03 0.3 4.85e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9788682 0.747 rs11072766 chr15:78771546 C/T cg24631222 chr15:78858424 CHRNA5 0.47 9.32 0.35 1.86e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs9368481 0.761 rs4358615 chr6:26998567 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.25 8.61 0.32 5.68e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg23758822 chr17:41437982 NA -0.76 -19.63 -0.61 1.61e-67 Menopause (age at onset); BRCA cis rs61931739 0.500 rs35391785 chr12:34444478 C/T cg06521331 chr12:34319734 NA -0.56 -10.01 -0.37 5.04e-22 Morning vs. evening chronotype; BRCA cis rs2180341 1.000 rs9398838 chr6:127635285 C/T cg27446573 chr6:127587934 RNF146 0.9 21.22 0.64 4.53e-76 Breast cancer; BRCA cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 11.64 0.42 1.62e-28 Mean platelet volume; BRCA cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.87 -0.3 1.48e-14 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg10578991 chr7:12443926 VWDE -0.53 -7.89 -0.3 1.34e-14 Coronary artery disease; BRCA cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg17971929 chr21:40555470 PSMG1 -0.51 -11.34 -0.41 2.75e-27 Menarche (age at onset); BRCA cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg27446573 chr6:127587934 RNF146 0.9 21.49 0.65 1.64e-77 Breast cancer; BRCA cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg26384229 chr12:38710491 ALG10B 0.84 22.54 0.67 2.99e-83 Heart rate; BRCA trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg27661571 chr11:113659931 NA -0.7 -10.79 -0.39 4.93e-25 Hip circumference adjusted for BMI; BRCA trans rs75804782 0.520 rs34058921 chr2:239318665 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 9.69 0.36 8.3e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg03709012 chr19:19516395 GATAD2A -0.75 -16.72 -0.55 2.46e-52 Tonsillectomy; BRCA cis rs672059 1.000 rs625917 chr1:183157991 T/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.08e-17 Hypertriglyceridemia; BRCA cis rs912057 1.000 rs912056 chr6:6736197 A/T cg06612196 chr6:6737390 NA 0.45 9.63 0.36 1.43e-20 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA trans rs9858542 0.953 rs11922013 chr3:49458355 G/C cg21659725 chr3:3221576 CRBN -0.46 -9.94 -0.37 9.86e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg06115741 chr20:33292138 TP53INP2 0.46 10.19 0.37 1.09e-22 Coronary artery disease; BRCA cis rs4853036 0.680 rs12612925 chr2:70112580 C/T cg02498382 chr2:70120550 SNRNP27 -0.59 -9.6 -0.35 1.8e-20 Colorectal or endometrial cancer; BRCA cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg04546413 chr19:29218101 NA -0.47 -8.23 -0.31 1.04e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg11663144 chr21:46675770 NA -0.62 -14.75 -0.5 1.35e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.36 -8.34 -0.31 4.49e-16 Longevity;Endometriosis; BRCA cis rs9527 0.590 rs7088200 chr10:104793235 G/A cg04362960 chr10:104952993 NT5C2 0.44 10.01 0.37 5.06e-22 Arsenic metabolism; BRCA cis rs1215050 0.740 rs783924 chr4:98969234 C/T cg05340658 chr4:99064831 C4orf37 -0.49 -11.36 -0.41 2.25e-27 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs1459104 1.000 rs12577269 chr11:55062905 C/T cg15704280 chr7:45808275 SEPT13 0.69 8.63 0.32 4.7e-17 Body mass index; BRCA cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg08000102 chr2:233561755 GIGYF2 -0.44 -9.62 -0.36 1.48e-20 Coronary artery disease; BRCA cis rs9788682 0.633 rs2656070 chr15:78730252 A/G cg24631222 chr15:78858424 CHRNA5 -0.5 -9.95 -0.37 9.13e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA trans rs11098499 0.863 rs59732491 chr4:120489588 G/C cg25214090 chr10:38739885 LOC399744 0.54 11.83 0.42 2.49e-29 Corneal astigmatism; BRCA cis rs1868673 1.000 rs28514580 chr3:150154365 G/T cg04908077 chr3:150187338 NA -0.33 -8.99 -0.34 2.8e-18 Waist circumference; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg26608667 chr7:1196370 ZFAND2A 0.45 10.75 0.39 7.09e-25 Longevity;Endometriosis; BRCA cis rs11190604 1.000 rs3750626 chr10:102266316 C/T cg07080220 chr10:102295463 HIF1AN 0.61 14.51 0.5 1.97e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg21535247 chr6:8435926 SLC35B3 0.41 9.38 0.35 1.09e-19 Motion sickness; BRCA cis rs9486719 0.947 rs2472908 chr6:96875998 A/T cg06623918 chr6:96969491 KIAA0776 0.73 12.85 0.45 8.92e-34 Migraine;Coronary artery disease; BRCA cis rs2243480 1.000 rs7795242 chr7:65390094 T/C cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs6089584 0.507 rs6061990 chr20:60628429 T/G cg13770153 chr20:60521292 NA -0.35 -8.22 -0.31 1.1e-15 Body mass index; BRCA cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2710642 0.927 rs2539980 chr2:63208460 T/C cg17519650 chr2:63277830 OTX1 0.45 10.01 0.37 5.09e-22 LDL cholesterol levels;LDL cholesterol; BRCA cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg23888215 chr10:79422304 NA 0.53 10.46 0.38 9.8e-24 Bone mineral density; BRCA cis rs2439831 0.850 rs61390361 chr15:44159842 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.94 0.46 3.57e-34 Lung cancer in ever smokers; BRCA cis rs4363385 0.818 rs1334849 chr1:153004652 A/G cg24667326 chr1:152973720 SPRR3 0.32 9.01 0.34 2.34e-18 Inflammatory skin disease; BRCA cis rs7523050 0.643 rs17563938 chr1:109401654 C/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs2806561 0.929 rs9426694 chr1:23539742 T/C cg12483005 chr1:23474871 LUZP1 0.38 8.15 0.31 1.87e-15 Height; BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18301423 chr5:131593218 PDLIM4 0.34 8.74 0.33 2.05e-17 Breast cancer; BRCA trans rs2204008 0.837 rs4312131 chr12:38181087 G/T cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg24812749 chr6:127587940 RNF146 0.88 20.63 0.63 7.68e-73 Breast cancer; BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26314531 chr2:26401878 FAM59B 0.95 16.42 0.54 8.01e-51 Gut microbiome composition (summer); BRCA cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg20701182 chr2:24300061 SF3B14 0.7 13.41 0.47 2.62e-36 Lymphocyte counts; BRCA cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs13053817 0.948 rs67613029 chr22:29836569 T/A cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.5 -9.91 -0.36 1.29e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -8.14 -0.31 2.03e-15 Bipolar disorder and schizophrenia; BRCA cis rs4561483 0.864 rs190461 chr16:12005745 A/G cg08843971 chr16:11963173 GSPT1 -0.46 -9.23 -0.34 3.93e-19 Testicular germ cell tumor; BRCA cis rs12545109 0.800 rs1960725 chr8:57411807 C/T cg09654669 chr8:57350985 NA -0.38 -8.34 -0.31 4.55e-16 Obesity-related traits; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.29 -0.31 6.76e-16 Total body bone mineral density; BRCA cis rs6831352 1.000 rs1126673 chr4:100045616 C/T cg12011299 chr4:100065546 ADH4 0.53 12.88 0.45 6.56e-34 Alcohol dependence; BRCA cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg15145296 chr3:125709740 NA -0.54 -8.58 -0.32 7.1e-17 Blood pressure (smoking interaction); BRCA cis rs477692 0.837 rs543454 chr10:131420536 T/C cg05714579 chr10:131428358 MGMT 0.56 13.76 0.48 6.25e-38 Response to temozolomide; BRCA cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg22875332 chr1:76189707 ACADM 0.79 18.87 0.6 1.86e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg22638593 chr5:131593259 PDLIM4 0.3 7.82 0.3 2.18e-14 Breast cancer; BRCA cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg24110177 chr3:50126178 RBM5 -0.36 -9.52 -0.35 3.41e-20 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs9467773 1.000 rs9393732 chr6:26530898 G/A cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg11644478 chr21:40555479 PSMG1 0.84 18.76 0.6 7.26e-63 Cognitive function; BRCA cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.74 10.3 0.38 3.96e-23 Initial pursuit acceleration; BRCA trans rs2204008 0.837 rs11180482 chr12:38235950 G/A cg06521331 chr12:34319734 NA -0.49 -9.07 -0.34 1.51e-18 Bladder cancer; BRCA cis rs61990749 0.597 rs17106157 chr14:78146878 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.05 -0.37 3.59e-22 Fibroblast growth factor basic levels; BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -9.35 -0.35 1.48e-19 Alzheimer's disease; BRCA cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg24229701 chr12:130821962 PIWIL1 0.39 8.89 0.33 6.08e-18 Menopause (age at onset); BRCA cis rs10992471 0.603 rs11792019 chr9:95195229 C/T cg14631576 chr9:95140430 CENPP -0.39 -9.32 -0.35 1.83e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg06766960 chr11:133703094 NA -0.64 -13.18 -0.46 2.89e-35 Childhood ear infection; BRCA cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg22800045 chr5:56110881 MAP3K1 -0.41 -8.25 -0.31 9.22e-16 Initial pursuit acceleration; BRCA cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.62 13.04 0.46 1.23e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.55 -12.15 -0.43 9.96e-31 Chronic sinus infection; BRCA cis rs2171564 0.557 rs3846043 chr3:112436847 A/C cg06685282 chr3:112453648 NA -0.48 -11.22 -0.41 8.9e-27 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs9420 0.961 rs71484468 chr11:57632799 G/C cg19752551 chr11:57585705 CTNND1 -0.51 -12.68 -0.45 5.05e-33 Schizophrenia; BRCA cis rs28830936 1.000 rs112896623 chr15:42001845 C/T cg17847044 chr15:42102381 MAPKBP1 -0.35 -9.72 -0.36 6.26e-21 Diastolic blood pressure; BRCA trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg25517755 chr10:38738941 LOC399744 -0.37 -7.81 -0.3 2.32e-14 Corneal astigmatism; BRCA cis rs6087990 0.735 rs1040554 chr20:31380073 C/T cg13636640 chr20:31349939 DNMT3B 0.61 18.01 0.58 5.63e-59 Ulcerative colitis; BRCA cis rs3784262 0.528 rs4553566 chr15:58336319 T/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -9.99 -0.37 6.14e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg15448220 chr1:150897856 SETDB1 0.35 7.81 0.3 2.32e-14 Melanoma; BRCA cis rs8031584 0.958 rs3512 chr15:31235005 G/C cg08704250 chr15:31115839 NA -0.36 -8.98 -0.33 2.91e-18 Huntington's disease progression; BRCA cis rs41307935 0.722 rs12724052 chr1:27234682 G/A cg12203394 chr1:27248618 NUDC 0.6 9.35 0.35 1.44e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.56 9.94 0.37 9.35e-22 Lung cancer in ever smokers; BRCA cis rs757081 0.738 rs1073443 chr11:17350394 C/T cg15432903 chr11:17409602 KCNJ11 -0.52 -9.34 -0.35 1.61e-19 Systolic blood pressure; BRCA cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg03877680 chr5:178157825 ZNF354A 0.58 9.6 0.35 1.82e-20 Neutrophil percentage of white cells; BRCA cis rs6429082 0.749 rs291362 chr1:235686690 T/A cg26050004 chr1:235667680 B3GALNT2 0.55 14.41 0.5 5.73e-41 Adiposity; BRCA cis rs672059 1.000 rs559476 chr1:183160704 T/C ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.46e-17 Hypertriglyceridemia; BRCA cis rs11711311 1.000 rs9830978 chr3:113455940 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs295137 0.725 rs1729413 chr2:201086663 T/G cg23649088 chr2:200775458 C2orf69 0.42 9.07 0.34 1.48e-18 Asthma (bronchodilator response); BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg20007245 chr22:24372913 LOC391322 0.55 12.1 0.43 1.77e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg26384229 chr12:38710491 ALG10B -0.56 -13.95 -0.48 8.26e-39 Morning vs. evening chronotype; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg22903471 chr2:27725779 GCKR -0.39 -9.42 -0.35 8.08e-20 Total body bone mineral density; BRCA cis rs2066819 0.892 rs117305040 chr12:56657888 A/G cg26714650 chr12:56694279 CS -1.16 -15.21 -0.52 8.38e-45 Psoriasis vulgaris; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.05 21.9 0.65 9.95e-80 Gut microbiome composition (summer); BRCA cis rs312274 0.657 rs932908 chr12:41213186 C/G cg17827154 chr12:41323612 CNTN1 0.36 8.84 0.33 9.17e-18 Metabolite levels (X-11787); BRCA cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg08999081 chr20:33150536 PIGU -0.34 -8.8 -0.33 1.26e-17 Glomerular filtration rate (creatinine); BRCA cis rs1348850 0.526 rs2218575 chr2:178368997 C/A cg27490568 chr2:178487706 NA 0.5 8.4 0.32 2.91e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg08847533 chr14:75593920 NEK9 0.83 20.57 0.63 1.56e-72 Height; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg03188948 chr7:1209495 NA 0.8 11.58 0.42 2.84e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4803468 1.000 rs2569754 chr19:41936734 A/G cg09537434 chr19:41945824 ATP5SL -1.02 -23.64 -0.68 2.82e-89 Height; BRCA cis rs7246657 0.653 rs4805208 chr19:37674259 G/A cg23950597 chr19:37808831 NA -0.66 -10.18 -0.37 1.21e-22 Coronary artery calcification; BRCA cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg24692254 chr21:30365293 RNF160 0.6 15.6 0.53 9.82e-47 Dental caries; BRCA cis rs1018836 0.923 rs10808615 chr8:91569704 A/T cg16814680 chr8:91681699 NA -0.64 -14.25 -0.49 3.37e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg20503657 chr10:835505 NA 0.88 16.06 0.54 5.38e-49 Eosinophil percentage of granulocytes; BRCA trans rs2832077 0.527 rs2142375 chr21:30223742 G/A cg14791747 chr16:20752902 THUMPD1 0.45 14.26 0.49 3.08e-40 Cognitive test performance; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg21782813 chr7:2030301 MAD1L1 0.32 8.56 0.32 8.63e-17 Bipolar disorder and schizophrenia; BRCA cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg12365402 chr11:9010492 NRIP3 0.44 9.7 0.36 7.45e-21 Hemoglobin concentration; BRCA cis rs11123610 0.520 rs11682697 chr2:3721127 A/G cg19052272 chr2:3704530 ALLC -0.46 -10.37 -0.38 2.13e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs367943 1.000 rs348963 chr5:112819027 A/G cg12552261 chr5:112820674 MCC -0.55 -12.21 -0.43 5.85e-31 Type 2 diabetes; BRCA cis rs495337 0.760 rs615868 chr20:48519224 C/T cg17835207 chr20:48524531 SPATA2 -0.67 -16.04 -0.54 6.74e-49 Psoriasis; BRCA cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg23711669 chr6:146136114 FBXO30 0.74 17.75 0.57 1.29e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs9287719 0.649 rs2884232 chr2:10719679 C/A cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.62e-19 Prostate cancer; BRCA cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg17063962 chr7:91808500 NA 0.61 14.56 0.5 1.08e-41 Breast cancer; BRCA cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 1.000 rs12200962 chr6:25828986 T/C cg17691542 chr6:26056736 HIST1H1C 0.76 13.47 0.47 1.44e-36 Iron status biomarkers; BRCA cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.53e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6665290 0.870 rs17600725 chr1:227204231 A/G cg10327440 chr1:227177885 CDC42BPA -1.12 -40.27 -0.85 1.8e-177 Myeloid white cell count; BRCA cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg18904891 chr8:8559673 CLDN23 0.57 11.36 0.41 2.35e-27 Obesity-related traits; BRCA cis rs12950390 0.853 rs12451815 chr17:45855956 A/G cg03474202 chr17:45855739 NA -0.43 -11.29 -0.41 4.35e-27 IgG glycosylation; BRCA cis rs10911232 0.524 rs10911229 chr1:183050368 C/G ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.74e-54 Hypertriglyceridemia; BRCA trans rs9329221 0.698 rs35388602 chr8:10259188 T/C cg06636001 chr8:8085503 FLJ10661 0.48 9.37 0.35 1.25e-19 Neuroticism; BRCA cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg01849466 chr14:104193079 ZFYVE21 0.42 10.74 0.39 7.67e-25 Schizophrenia; BRCA cis rs1506636 1.000 rs767637 chr7:123321978 C/A cg03229431 chr7:123269106 ASB15 -0.62 -14.06 -0.49 2.56e-39 Plateletcrit;Platelet count; BRCA cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg03517284 chr6:25882590 NA -0.51 -10.21 -0.37 8.72e-23 Intelligence (multi-trait analysis); BRCA cis rs4845875 0.529 rs6680385 chr1:11831756 A/G cg24844545 chr1:11908347 NPPA 0.36 8.26 0.31 8.62e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg04511125 chr2:88470314 THNSL2 -0.51 -10.57 -0.39 3.57e-24 Response to metformin (IC50); BRCA cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24308560 chr3:49941425 MST1R -0.4 -8.55 -0.32 9.36e-17 Intelligence (multi-trait analysis); BRCA cis rs1555322 0.530 rs2297789 chr20:33867248 A/T cg17927777 chr20:33865990 NA 0.43 8.21 0.31 1.21e-15 Attention deficit hyperactivity disorder; BRCA cis rs701145 0.585 rs1713846 chr3:153787632 C/T cg17054900 chr3:154042577 DHX36 0.53 9.19 0.34 5.62e-19 Coronary artery disease; BRCA cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg00012203 chr2:219082015 ARPC2 0.72 16.03 0.54 7.42e-49 Colorectal cancer; BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg08219700 chr8:58056026 NA 0.55 9.0 0.34 2.66e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.697 rs4373140 chr4:120307698 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.11 0.31 2.55e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs10506458 1.000 rs73128794 chr12:63445313 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.18 -17.87 -0.58 3.08e-58 Hemostatic factors and hematological phenotypes; BRCA cis rs7254827 1.000 rs12977780 chr19:17213558 A/T cg19418318 chr19:17219073 MYO9B -0.49 -10.25 -0.38 6.25e-23 Mean platelet volume; BRCA cis rs11626933 0.959 rs2149649 chr14:90774974 A/G cg14092571 chr14:90743983 NA 0.75 19.87 0.62 9.14e-69 Gut microbiota (bacterial taxa); BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.55 8.81 0.33 1.21e-17 Renal function-related traits (BUN); BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg08888203 chr3:10149979 C3orf24 0.59 12.5 0.44 3.15e-32 Alzheimer's disease; BRCA cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.98 0.46 2.24e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg04025307 chr7:1156635 C7orf50 0.59 9.3 0.35 2.29e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4713118 0.738 rs200465 chr6:27757654 T/A cg20933634 chr6:27740509 NA 0.46 8.99 0.34 2.71e-18 Parkinson's disease; BRCA cis rs9463078 0.683 rs6458412 chr6:44735834 A/G cg25276700 chr6:44698697 NA 0.37 8.04 0.3 4.37e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs783540 0.843 rs9652567 chr15:83368514 T/G cg18393722 chr15:85113863 UBE2QP1 0.28 8.62 0.32 5.34e-17 Schizophrenia; BRCA cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg04025307 chr7:1156635 C7orf50 0.76 19.61 0.61 2.15e-67 Longevity;Endometriosis; BRCA cis rs4363385 0.747 rs4845509 chr1:152981900 T/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.85 -0.36 2.03e-21 Inflammatory skin disease; BRCA trans rs57221529 0.709 rs4957056 chr5:570105 T/C cg11887960 chr12:57824829 NA 0.52 8.65 0.32 4.06e-17 Lung disease severity in cystic fibrosis; BRCA cis rs6831352 0.918 rs4699713 chr4:100060513 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.76 -0.42 5.05e-29 Alcohol dependence; BRCA cis rs10927875 0.726 rs1763603 chr1:16339809 T/C cg22431228 chr1:16359049 CLCNKA -0.45 -9.02 -0.34 2.26e-18 Dilated cardiomyopathy; BRCA cis rs7647973 0.626 rs9835157 chr3:49797769 G/A cg07636037 chr3:49044803 WDR6 -0.5 -8.25 -0.31 9.35e-16 Menarche (age at onset); BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18402987 chr7:1209562 NA 0.62 13.01 0.46 1.67e-34 Longevity;Endometriosis; BRCA cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg03433033 chr1:76189801 ACADM -0.5 -9.94 -0.37 9.81e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg24531977 chr5:56204891 C5orf35 -0.87 -17.88 -0.58 2.78e-58 Initial pursuit acceleration; BRCA cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg01017244 chr2:74357527 NA 0.64 12.56 0.45 1.67e-32 Gestational age at birth (maternal effect); BRCA cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs10089 1.000 rs2898096 chr5:127433214 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 16.42 0.54 8.25e-51 Ileal carcinoids; BRCA cis rs6831352 0.734 rs3100630 chr4:100031715 T/A cg12011299 chr4:100065546 ADH4 0.42 10.52 0.38 5.65e-24 Alcohol dependence; BRCA cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg10523679 chr1:76189770 ACADM 0.91 22.32 0.66 4.84e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg22117172 chr7:91764530 CYP51A1 -0.23 -7.87 -0.3 1.5e-14 Breast cancer; BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg04944784 chr2:26401820 FAM59B 0.65 11.0 0.4 7.05e-26 Gut microbiome composition (summer); BRCA cis rs250677 0.687 rs36044 chr5:148441128 T/C cg12140854 chr5:148520817 ABLIM3 -0.41 -8.71 -0.33 2.59e-17 Breast cancer; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -11.96 -0.43 6.53e-30 Alzheimer's disease; BRCA cis rs16958440 0.867 rs3809965 chr18:44676872 G/A cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs16854884 0.657 rs16854819 chr3:143736126 C/T cg06585982 chr3:143692056 C3orf58 -0.41 -8.7 -0.33 2.8e-17 Economic and political preferences (feminism/equality); BRCA cis rs965469 0.843 rs6051698 chr20:3248983 T/C cg25506879 chr20:3388711 C20orf194 -0.46 -9.14 -0.34 7.88e-19 IFN-related cytopenia; BRCA cis rs2651899 0.902 rs1736522 chr1:3080940 C/G cg07622451 chr1:3079886 PRDM16 0.28 7.83 0.3 2.05e-14 Migraine; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg08999081 chr20:33150536 PIGU -0.39 -10.12 -0.37 2.07e-22 Coronary artery disease; BRCA cis rs77972916 0.505 rs34247383 chr2:43532780 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -10.15 -0.37 1.53e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs9486715 0.838 rs9486275 chr6:96901187 C/T cg06623918 chr6:96969491 KIAA0776 0.9 26.0 0.72 3.17e-102 Headache; BRCA cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg00686598 chr14:53173677 PSMC6 1.2 15.67 0.53 4.28e-47 Alzheimer's disease (late onset); BRCA cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA trans rs330048 0.545 rs11249913 chr8:9143521 G/T cg06636001 chr8:8085503 FLJ10661 -0.62 -13.45 -0.47 1.78e-36 Systemic lupus erythematosus; BRCA trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg21775007 chr8:11205619 TDH -0.4 -8.19 -0.31 1.41e-15 Neuroticism; BRCA cis rs9814567 1.000 rs9883753 chr3:134247231 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.11 -0.34 1.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.15 -0.49 1.01e-39 Extrinsic epigenetic age acceleration; BRCA cis rs9807989 0.507 rs6745614 chr2:102991213 A/G cg03938978 chr2:103052716 IL18RAP 0.28 8.28 0.31 7.17e-16 Asthma; BRCA cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg09417038 chr21:47716443 C21orf57 0.32 8.3 0.31 6.23e-16 Testicular germ cell tumor; BRCA cis rs1401999 1.000 rs2313217 chr3:183635997 A/G cg20387954 chr3:183756860 HTR3D 0.44 9.77 0.36 4.25e-21 Anterior chamber depth; BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg08280861 chr8:58055591 NA 0.56 8.74 0.33 2.09e-17 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.790 rs10223507 chr6:146285204 C/A cg23711669 chr6:146136114 FBXO30 -0.69 -16.0 -0.53 1.06e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs2072438 0.503 rs10739590 chr9:123871481 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.42 0.32 2.47e-16 Rheumatoid arthritis; BRCA trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg13010199 chr12:38710504 ALG10B 0.42 8.94 0.33 4.26e-18 Morning vs. evening chronotype; BRCA cis rs1975991 0.576 rs4449306 chr3:187952376 G/T cg15417654 chr3:187959138 LPP -0.36 -9.45 -0.35 6.32e-20 White matter integrity (bipolar disorder risk interaction); BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg01262667 chr19:19385393 TM6SF2 -0.42 -10.94 -0.4 1.16e-25 Tonsillectomy; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.78 -12.54 -0.44 2.13e-32 Platelet count; BRCA cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg01689657 chr7:91764605 CYP51A1 0.21 7.86 0.3 1.61e-14 Breast cancer; BRCA cis rs10876993 0.928 rs1678530 chr12:58054076 A/C cg18357645 chr12:58087776 OS9 0.42 11.95 0.43 7.78e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg00750074 chr16:89608354 SPG7 -0.36 -9.47 -0.35 5.19e-20 Multiple myeloma (IgH translocation); BRCA cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg16339924 chr4:17578868 LAP3 0.68 17.26 0.56 4.44e-55 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9503598 1.000 rs9503598 chr6:3446263 A/G cg00476032 chr6:3446245 SLC22A23 -0.47 -11.76 -0.42 4.98e-29 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs9831754 1.000 rs112170848 chr3:78359996 G/A cg06138941 chr3:78371609 NA -0.81 -17.54 -0.57 1.59e-56 Calcium levels; BRCA cis rs4664304 0.620 rs4665125 chr2:160714314 C/G cg14819504 chr2:160761413 LY75 0.34 8.37 0.31 3.66e-16 Crohn's disease;Inflammatory bowel disease; BRCA trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg15556689 chr8:8085844 FLJ10661 0.37 9.99 0.37 6.28e-22 Recombination measurement; BRCA cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg17971929 chr21:40555470 PSMG1 -0.6 -13.43 -0.47 2.11e-36 Cognitive function; BRCA cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00934597 chr7:893267 UNC84A -0.54 -12.03 -0.43 3.42e-30 Perceived unattractiveness to mosquitoes; BRCA cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs17253792 0.822 rs79291233 chr14:56065302 G/C cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs3845702 0.800 rs6744281 chr2:180844382 G/A cg01881094 chr2:180872142 CWC22 -1.01 -18.23 -0.58 4.24e-60 Schizophrenia; BRCA cis rs4363385 0.747 rs2879488 chr1:152975241 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs4742903 0.527 rs10991112 chr9:106878906 C/T cg14250997 chr9:106856677 SMC2 0.29 8.47 0.32 1.66e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg13271783 chr10:134563150 INPP5A -0.46 -9.52 -0.35 3.37e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6752107 0.901 rs2289477 chr2:234160345 T/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.33 0.41 2.94e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22496380 chr5:211416 CCDC127 -1.01 -14.34 -0.49 1.26e-40 Breast cancer; BRCA cis rs67460515 0.528 rs11915989 chr3:160902259 A/G cg17135325 chr3:160939158 NMD3 0.45 8.64 0.32 4.35e-17 Parkinson's disease; BRCA cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 11.38 0.41 1.87e-27 Systemic lupus erythematosus; BRCA cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.69 0.5 2.56e-42 Colorectal cancer; BRCA cis rs17270561 0.609 rs9358885 chr6:25758024 T/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.67 0.32 3.53e-17 Iron status biomarkers; BRCA cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg24675658 chr1:53192096 ZYG11B -0.69 -15.56 -0.52 1.56e-46 Monocyte count; BRCA cis rs11249608 0.548 rs10516150 chr5:178459169 G/C cg21905437 chr5:178450457 ZNF879 0.51 10.65 0.39 1.68e-24 Pubertal anthropometrics; BRCA cis rs28595532 0.920 rs112016126 chr4:119726528 C/T cg14228332 chr4:119757509 SEC24D 0.67 7.95 0.3 8.23e-15 Cannabis dependence symptom count; BRCA cis rs17095355 1.000 rs12265204 chr10:111752163 T/C cg00817464 chr10:111662876 XPNPEP1 -0.4 -9.98 -0.37 6.53e-22 Biliary atresia; BRCA cis rs858239 0.665 rs858306 chr7:23242754 A/T cg23682824 chr7:23144976 KLHL7 0.31 8.0 0.3 5.71e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs3125734 0.633 rs3765002 chr10:64006124 G/T cg19640130 chr10:64028056 RTKN2 -0.29 -8.25 -0.31 9.12e-16 Rheumatoid arthritis; BRCA cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg04450456 chr4:17643702 FAM184B 0.32 9.43 0.35 7.47e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg23583168 chr7:148888333 NA 0.85 19.93 0.62 4.17e-69 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7044106 0.537 rs10739573 chr9:123489818 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.29 0.41 4.35e-27 Hip circumference adjusted for BMI; BRCA cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg00071950 chr4:10020882 SLC2A9 0.62 15.02 0.51 6.62e-44 Bone mineral density; BRCA cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg04414720 chr1:150670196 GOLPH3L -0.35 -7.92 -0.3 1.07e-14 Tonsillectomy; BRCA cis rs9394841 0.692 rs13193235 chr6:41792659 T/C cg08135965 chr6:41755394 TOMM6 0.5 8.3 0.31 6.25e-16 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs7631605 0.905 rs11920928 chr3:37210874 T/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.87 0.36 1.69e-21 Cerebrospinal P-tau181p levels; BRCA cis rs9815354 0.812 rs78342280 chr3:41948810 G/A cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.94 0.43 8.34e-30 Tonsillectomy; BRCA cis rs939658 1.000 rs939658 chr15:79451869 A/G cg17916960 chr15:79447300 NA 0.38 9.58 0.35 2.03e-20 Refractive error; BRCA cis rs477692 0.699 rs576175 chr10:131386408 A/T cg05714579 chr10:131428358 MGMT 0.5 11.24 0.41 7.21e-27 Response to temozolomide; BRCA trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg08975724 chr8:8085496 FLJ10661 -0.39 -7.89 -0.3 1.33e-14 Triglycerides; BRCA trans rs1994135 0.715 rs10844625 chr12:33693006 C/T cg26384229 chr12:38710491 ALG10B 0.4 8.6 0.32 6.3e-17 Resting heart rate; BRCA trans rs6479891 1.000 rs9415707 chr10:65188290 T/C cg14819942 chr15:35414228 NA 0.35 8.58 0.32 7.31e-17 Arthritis (juvenile idiopathic); BRCA cis rs7737355 0.898 rs2161414 chr5:131063073 C/T cg06307176 chr5:131281290 NA 0.52 10.07 0.37 3.09e-22 Life satisfaction; BRCA cis rs10876993 0.928 rs1678540 chr12:58065002 A/G cg18357645 chr12:58087776 OS9 0.47 13.49 0.47 1.19e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs7103648 1.000 rs7103648 chr11:47461783 A/G cg03711944 chr11:47377212 SPI1 -0.42 -11.31 -0.41 3.51e-27 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22509189 chr2:225307070 NA -0.47 -10.07 -0.37 3e-22 IgE levels in asthmatics (D.p. specific); BRCA cis rs2880765 0.677 rs7181410 chr15:86006335 A/G cg10818794 chr15:86012489 AKAP13 0.29 8.02 0.3 5.02e-15 Coronary artery disease; BRCA trans rs9951602 0.512 rs9952372 chr18:76656295 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 17.81 0.58 6.42e-58 Obesity-related traits; BRCA cis rs4285028 0.699 rs1920298 chr3:121597888 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.16 -0.46 3.63e-35 Multiple sclerosis; BRCA trans rs11098499 0.863 rs11947234 chr4:120474859 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs8017423 0.935 rs3783838 chr14:90733012 A/G cg04374321 chr14:90722782 PSMC1 -0.71 -18.51 -0.59 1.37e-61 Mortality in heart failure; BRCA cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg00106254 chr7:1943704 MAD1L1 -0.42 -10.21 -0.37 8.77e-23 Bipolar disorder and schizophrenia; BRCA cis rs17767294 0.614 rs41269291 chr6:28251539 A/G cg08851530 chr6:28072375 NA 1.14 10.34 0.38 2.73e-23 Parkinson's disease; BRCA cis rs4481887 1.000 rs6671789 chr1:248482931 G/A cg00666640 chr1:248458726 OR2T12 0.34 9.12 0.34 9.72e-19 Common traits (Other); BRCA cis rs6570726 1.000 rs1935617 chr6:145943326 C/T cg23711669 chr6:146136114 FBXO30 0.62 14.06 0.49 2.59e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 1.000 rs6050547 chr20:25326012 C/T cg08601574 chr20:25228251 PYGB -0.37 -8.84 -0.33 9.28e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7254827 0.784 rs4808570 chr19:17220720 G/A cg19418318 chr19:17219073 MYO9B -0.51 -10.29 -0.38 4.28e-23 Mean platelet volume; BRCA cis rs7246657 0.722 rs2927742 chr19:38133618 T/C cg18154014 chr19:37997991 ZNF793 -0.49 -9.24 -0.34 3.72e-19 Coronary artery calcification; BRCA cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg27446573 chr6:127587934 RNF146 0.89 20.53 0.63 2.62e-72 Breast cancer; BRCA cis rs3784262 0.647 rs2414529 chr15:58317094 G/T cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.31 -0.38 3.63e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs13095912 1.000 rs13340181 chr3:185325612 T/C cg11274856 chr3:185301563 NA 0.34 8.56 0.32 8.61e-17 Systolic blood pressure; BRCA cis rs9790314 0.765 rs4856768 chr3:161004392 G/A cg04691961 chr3:161091175 C3orf57 -0.44 -10.57 -0.39 3.54e-24 Morning vs. evening chronotype; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg04267008 chr7:1944627 MAD1L1 -0.56 -12.46 -0.44 4.76e-32 Bipolar disorder and schizophrenia; BRCA cis rs4363385 0.720 rs1970328 chr1:152975829 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.83 -0.3 2.04e-14 Aortic root size; BRCA cis rs1878931 0.582 rs10048083 chr16:3417465 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.47 8.41 0.32 2.72e-16 Body mass index (adult); BRCA cis rs2629540 0.924 rs2629541 chr10:126425866 G/A cg08799069 chr10:126477246 METTL10 0.49 9.68 0.36 8.67e-21 Cocaine dependence; BRCA cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg03213289 chr20:61660250 NA 0.63 16.62 0.55 7.73e-52 Prostate cancer (SNP x SNP interaction); BRCA cis rs9467773 0.523 rs2498399 chr6:26706544 T/C cg11502198 chr6:26597334 ABT1 0.46 8.97 0.33 3.22e-18 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.26 0.31 8.57e-16 Platelet count; BRCA cis rs9287719 0.967 rs2287061 chr2:10743153 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.87e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs208520 0.770 rs2153941 chr6:66885521 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -18.36 -0.59 8.41e-61 Exhaled nitric oxide output; BRCA cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg23719950 chr11:63933701 MACROD1 -0.53 -8.74 -0.33 2.07e-17 Mean platelet volume; BRCA cis rs2806561 0.765 rs1738469 chr1:23511407 G/C cg12483005 chr1:23474871 LUZP1 0.46 10.22 0.37 7.96e-23 Height; BRCA cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg25174290 chr11:3078921 CARS 0.4 11.14 0.4 1.75e-26 Longevity; BRCA cis rs7100689 0.646 rs10466235 chr10:82149655 C/T cg00277334 chr10:82204260 NA 0.4 8.09 0.3 2.92e-15 Post bronchodilator FEV1; BRCA cis rs877282 0.583 rs10904566 chr10:821662 C/G cg15764593 chr10:829463 NA -0.64 -10.26 -0.38 6.01e-23 Uric acid levels; BRCA cis rs7677751 0.806 rs6850748 chr4:55099164 T/G cg17187183 chr4:55093834 PDGFRA 0.44 9.06 0.34 1.53e-18 Corneal astigmatism; BRCA cis rs13102973 0.932 rs28801464 chr4:135876630 A/G cg14419869 chr4:135874104 NA -0.59 -13.0 -0.46 1.93e-34 Subjective well-being; BRCA cis rs208520 0.674 rs207103 chr6:66795568 G/T cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs875971 0.660 rs801192 chr7:66031952 C/G cg11764359 chr7:65958608 NA -0.68 -15.39 -0.52 1.07e-45 Aortic root size; BRCA cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg12386194 chr3:101231763 SENP7 0.45 9.45 0.35 6.14e-20 Colorectal cancer; BRCA cis rs11711311 0.955 rs12634241 chr3:113397685 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.31 7.92 0.3 1.03e-14 IgG glycosylation; BRCA cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg20607798 chr8:58055168 NA 0.48 8.31 0.31 5.67e-16 Developmental language disorder (linguistic errors); BRCA cis rs4711336 1.000 rs2296742 chr6:33659793 G/A cg14003231 chr6:33640908 ITPR3 0.32 7.87 0.3 1.51e-14 Height; BRCA cis rs7512552 0.698 rs12028001 chr1:150407820 C/T cg15654264 chr1:150340011 RPRD2 0.37 8.21 0.31 1.24e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg23018236 chr17:30244563 NA -0.48 -9.06 -0.34 1.52e-18 Hip circumference adjusted for BMI; BRCA cis rs600231 0.542 rs11227198 chr11:65237974 G/A cg01292856 chr11:65242576 NA 0.66 14.93 0.51 1.76e-43 Bone mineral density; BRCA cis rs344364 0.511 rs2982455 chr16:1950498 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -9.73 -0.36 6.09e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs10751667 0.643 rs10794350 chr11:946070 A/G ch.11.42038R chr11:967971 AP2A2 0.49 15.39 0.52 1.13e-45 Alzheimer's disease (late onset); BRCA cis rs9547692 1.000 rs493248 chr13:37473386 C/T cg01493522 chr13:37497338 NA -0.45 -9.72 -0.36 6.54e-21 Coronary artery disease; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg22907277 chr7:1156413 C7orf50 0.52 11.23 0.41 8.09e-27 Longevity;Endometriosis; BRCA cis rs4363385 0.747 rs4255332 chr1:152958745 G/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.84e-16 Inflammatory skin disease; BRCA cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg10802521 chr3:52805072 NEK4 -0.36 -9.84 -0.36 2.29e-21 Bipolar disorder; BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.3 -0.31 5.99e-16 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.58 0.35 2.14e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg11952622 chr19:58962976 ZNF324B 0.5 10.44 0.38 1.16e-23 Uric acid clearance; BRCA cis rs72781680 1.000 rs72781671 chr2:24231123 A/G cg08917208 chr2:24149416 ATAD2B 1.08 15.0 0.51 8.89e-44 Lymphocyte counts; BRCA cis rs11190604 1.000 rs11190601 chr10:102296730 A/G cg07080220 chr10:102295463 HIF1AN 0.63 15.04 0.51 5.67e-44 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9790314 0.663 rs5004752 chr3:160748380 A/T cg03342759 chr3:160939853 NMD3 -0.46 -8.7 -0.33 2.86e-17 Morning vs. evening chronotype; BRCA cis rs507080 0.845 rs509641 chr11:118558952 T/C cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg08859206 chr1:53392774 SCP2 0.45 10.09 0.37 2.5e-22 Monocyte count; BRCA cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg11941060 chr3:133502564 NA 0.46 11.26 0.41 6.01e-27 Iron status biomarkers; BRCA cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.48 0.32 1.51e-16 Diabetic retinopathy; BRCA cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg08885076 chr2:99613938 TSGA10 -0.51 -9.98 -0.37 6.95e-22 Chronic sinus infection; BRCA cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg16179182 chr5:140090404 VTRNA1-1 0.46 10.91 0.4 1.63e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs2421770 0.530 rs7930134 chr11:35367017 A/C cg13971030 chr11:35366721 SLC1A2 -0.45 -10.12 -0.37 1.9e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs2806561 0.704 rs2746560 chr1:23526279 G/A cg19743168 chr1:23544995 NA 0.35 8.15 0.31 1.89e-15 Height; BRCA cis rs6138458 0.816 rs2151463 chr20:24911819 A/C cg26195577 chr20:24973756 C20orf3 0.98 24.72 0.7 3.46e-95 Blood protein levels; BRCA trans rs35110281 0.840 rs2838331 chr21:45026728 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -10.46 -0.38 9.94e-24 Mean corpuscular volume; BRCA cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs10911232 0.507 rs4651138 chr1:183001312 C/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.55 0.55 1.84e-51 Hypertriglyceridemia; BRCA cis rs9649465 0.967 rs13230230 chr7:123329603 G/A cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg22974920 chr21:40686053 BRWD1 -0.39 -8.76 -0.33 1.73e-17 Cognitive function; BRCA cis rs10883723 0.810 rs6584508 chr10:104258567 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.67 0.61 1.05e-67 Allergic disease (asthma, hay fever or eczema); BRCA cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg19418458 chr7:158789849 NA 0.43 9.67 0.36 9.4e-21 Facial morphology (factor 20); BRCA cis rs10760123 1 rs10760123 chr9:123650534 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.04 0.4 4.78e-26 Allergic disease (asthma, hay fever or eczema); BRCA cis rs10883723 0.962 rs1056739 chr10:104236542 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.6 17.47 0.57 3.6e-56 Allergic disease (asthma, hay fever or eczema); BRCA cis rs877282 0.891 rs11253406 chr10:796297 G/A cg17470449 chr10:769945 NA 0.51 8.71 0.33 2.54e-17 Uric acid levels; BRCA cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg02951883 chr7:2050386 MAD1L1 -0.35 -8.04 -0.3 4.43e-15 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9435341 0.965 rs6669831 chr1:107608607 G/A cg09367891 chr1:107599246 PRMT6 -0.43 -8.39 -0.32 3.01e-16 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs7267979 1.000 rs13038834 chr20:25441433 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg05793240 chr7:2802953 GNA12 -0.31 -7.87 -0.3 1.56e-14 Height; BRCA cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg13736514 chr6:26305472 NA -0.33 -11.43 -0.41 1.2e-27 Educational attainment; BRCA trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg25517755 chr10:38738941 LOC399744 -0.37 -7.84 -0.3 1.91e-14 Corneal astigmatism; BRCA cis rs796364 0.806 rs6743396 chr2:200860138 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.14 0.4 1.78e-26 Schizophrenia; BRCA cis rs8014204 0.816 rs10144023 chr14:75291531 T/C cg06637938 chr14:75390232 RPS6KL1 0.43 9.0 0.34 2.55e-18 Caffeine consumption; BRCA cis rs4595586 0.545 rs12831116 chr12:39401456 C/T cg26384229 chr12:38710491 ALG10B 0.56 11.61 0.42 2.05e-28 Morning vs. evening chronotype; BRCA cis rs11711311 1.000 rs3773682 chr3:113520576 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.74 -0.39 7.54e-25 IgG glycosylation; BRCA cis rs1707322 0.789 rs10789473 chr1:46248131 C/T cg03146154 chr1:46216737 IPP 0.53 11.64 0.42 1.6e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4363385 0.818 rs10788856 chr1:153011517 G/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.38 -7.96 -0.3 7.82e-15 Educational attainment; BRCA cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg17143192 chr8:8559678 CLDN23 0.53 10.29 0.38 4.47e-23 Obesity-related traits; BRCA cis rs7927771 0.864 rs55927797 chr11:47446292 A/T cg20307385 chr11:47447363 PSMC3 -0.43 -9.11 -0.34 1.08e-18 Subjective well-being; BRCA cis rs875971 0.638 rs10278816 chr7:66036987 T/C cg11764359 chr7:65958608 NA -0.68 -15.38 -0.52 1.14e-45 Aortic root size; BRCA cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg00814883 chr7:100076585 TSC22D4 -0.49 -10.38 -0.38 2e-23 Platelet count; BRCA cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg10802521 chr3:52805072 NEK4 -0.31 -7.86 -0.3 1.63e-14 Bipolar disorder; BRCA cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg01256987 chr12:42539512 GXYLT1 -0.57 -11.69 -0.42 9.68e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs1707322 0.721 rs11211158 chr1:46132850 C/G cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg05347473 chr6:146136440 FBXO30 0.43 8.54 0.32 9.64e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.74e-15 Developmental language disorder (linguistic errors); BRCA cis rs12579753 0.917 rs10778834 chr12:82199742 A/C cg07988820 chr12:82153109 PPFIA2 -0.47 -8.33 -0.31 5.03e-16 Resting heart rate; BRCA trans rs12517041 1.000 rs10054768 chr5:23278161 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.45 -8.11 -0.31 2.68e-15 Calcium levels; BRCA cis rs17641971 0.708 rs974781 chr8:49931055 T/A cg00325661 chr8:49890786 NA 0.35 9.59 0.35 1.98e-20 Blood metabolite levels; BRCA cis rs838147 0.844 rs12975033 chr19:49249443 A/T cg03531100 chr19:49260119 FGF21;FUT1 -0.36 -7.92 -0.3 1.04e-14 Dietary macronutrient intake; BRCA cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg06618935 chr21:46677482 NA -0.37 -8.38 -0.31 3.39e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.74 -0.36 5.3e-21 IgG glycosylation; BRCA cis rs1971762 0.523 rs3852562 chr12:54085750 T/C cg23533419 chr12:54090519 NA -0.33 -8.39 -0.32 3.07e-16 Height; BRCA cis rs7944584 0.837 rs11039149 chr11:47276675 A/G cg03711944 chr11:47377212 SPI1 -0.41 -8.69 -0.32 3.12e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs2204008 0.506 rs11495470 chr12:38026904 C/T cg06521331 chr12:34319734 NA -0.54 -10.21 -0.37 8.63e-23 Bladder cancer; BRCA cis rs4845570 1.000 rs6683364 chr1:151746202 T/A cg07092448 chr1:151763213 TDRKH -0.86 -16.92 -0.56 2.44e-53 Coronary artery disease; BRCA cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg21573476 chr21:45109991 RRP1B -0.32 -8.12 -0.31 2.48e-15 Mean corpuscular volume; BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18301423 chr5:131593218 PDLIM4 0.31 7.98 0.3 6.78e-15 Breast cancer; BRCA cis rs9790314 0.543 rs1349352 chr3:161118486 C/T cg03342759 chr3:160939853 NMD3 -0.63 -14.14 -0.49 1.04e-39 Morning vs. evening chronotype; BRCA cis rs701145 0.556 rs355762 chr3:154012614 G/A cg16511985 chr3:153974050 SGEF 0.43 9.82 0.36 2.61e-21 Coronary artery disease; BRCA trans rs11098499 0.863 rs3736115 chr4:120488703 A/G cg25214090 chr10:38739885 LOC399744 -0.52 -11.51 -0.41 5.19e-28 Corneal astigmatism; BRCA cis rs7246657 0.722 rs10417576 chr19:38119212 A/C cg23950597 chr19:37808831 NA -0.49 -8.51 -0.32 1.28e-16 Coronary artery calcification; BRCA cis rs3784262 0.565 rs2642630 chr15:58316960 C/G cg12031962 chr15:58353849 ALDH1A2 -0.34 -8.96 -0.33 3.62e-18 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg10382835 chr6:42185730 MRPS10 0.53 8.89 0.33 6.39e-18 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs9283706 0.608 rs13171572 chr5:66334552 T/A cg11590213 chr5:66331682 MAST4 0.38 7.98 0.3 6.69e-15 Coronary artery disease; BRCA cis rs35740288 0.580 rs34635893 chr15:86340248 C/T cg20737812 chr15:86336631 KLHL25 -0.39 -9.45 -0.35 6.3e-20 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg11764359 chr7:65958608 NA -0.79 -18.7 -0.59 1.41e-62 Aortic root size; BRCA cis rs11608355 0.545 rs55902232 chr12:109902305 G/A cg05360138 chr12:110035743 NA 0.71 13.03 0.46 1.38e-34 Neuroticism; BRCA cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg01579765 chr21:45077557 HSF2BP -0.36 -9.66 -0.36 1.03e-20 Mean corpuscular volume; BRCA cis rs992157 0.835 rs2045434 chr2:219144498 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.18 -0.4 1.24e-26 Colorectal cancer; BRCA cis rs919433 0.680 rs699319 chr2:198281776 C/A cg00792783 chr2:198669748 PLCL1 0.38 8.57 0.32 7.95e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9290065 0.538 rs898682 chr3:160773133 G/C cg03342759 chr3:160939853 NMD3 -0.52 -10.27 -0.38 5.24e-23 Kawasaki disease; BRCA cis rs700651 0.789 rs1976772 chr2:198868201 G/T cg00792783 chr2:198669748 PLCL1 0.43 9.44 0.35 6.76e-20 Intracranial aneurysm; BRCA cis rs11112613 0.713 rs11112591 chr12:105951620 C/T cg03607813 chr12:105948248 NA 0.55 10.38 0.38 1.91e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg24829409 chr8:58192753 C8orf71 -0.48 -8.0 -0.3 6e-15 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.31 0.41 3.74e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs758324 0.947 rs56081930 chr5:131235274 T/G cg06307176 chr5:131281290 NA -0.57 -11.98 -0.43 5.62e-30 Alzheimer's disease in APOE e4- carriers; BRCA cis rs11955398 0.606 rs56137970 chr5:59873462 C/T cg02684056 chr5:59996105 DEPDC1B 0.35 8.25 0.31 9.29e-16 Intelligence (multi-trait analysis); BRCA cis rs9818758 0.607 rs9850917 chr3:49286983 A/G cg00383909 chr3:49044727 WDR6 0.71 12.7 0.45 4.18e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA trans rs877282 0.797 rs7079164 chr10:756363 A/G cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs7095944 0.584 rs4962693 chr10:126424835 C/T cg08799069 chr10:126477246 METTL10 -0.38 -8.85 -0.33 8.32e-18 Asthma; BRCA cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg11764359 chr7:65958608 NA -0.76 -17.43 -0.57 5.6e-56 Aortic root size; BRCA cis rs11098499 0.697 rs35280960 chr4:120257059 G/A cg09307838 chr4:120376055 NA 0.62 12.99 0.46 2.07e-34 Corneal astigmatism; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg25036284 chr2:26402008 FAM59B -0.88 -15.25 -0.52 5.02e-45 Gut microbiome composition (summer); BRCA cis rs9914988 0.943 rs9913801 chr17:27132105 G/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.8 -0.33 1.32e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs965469 1.000 rs1040727 chr20:3264292 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -9.51 -0.35 3.7e-20 IFN-related cytopenia; BRCA cis rs1558643 0.527 rs1861283 chr2:102728716 A/G cg22835712 chr2:102737379 NA -0.37 -7.89 -0.3 1.31e-14 Fibrinogen levels; BRCA trans rs4714291 0.792 rs9471241 chr6:40080211 C/T cg02267698 chr19:7991119 CTXN1 -0.45 -9.3 -0.35 2.11e-19 Strep throat; BRCA cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11890956 chr21:40555474 PSMG1 0.66 15.41 0.52 8.23e-46 Cognitive function; BRCA cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg02951883 chr7:2050386 MAD1L1 -0.37 -8.86 -0.33 7.75e-18 Schizophrenia; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg14004847 chr7:1930337 MAD1L1 -0.4 -7.89 -0.3 1.3e-14 Bipolar disorder and schizophrenia; BRCA cis rs763121 0.889 rs6001209 chr22:39121252 C/T cg21395723 chr22:39101663 GTPBP1 -0.36 -8.19 -0.31 1.43e-15 Menopause (age at onset); BRCA cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg11764359 chr7:65958608 NA 0.74 16.63 0.55 7.55e-52 Aortic root size; BRCA cis rs312274 0.630 rs1822599 chr12:41231299 T/C cg17827154 chr12:41323612 CNTN1 0.39 9.82 0.36 2.72e-21 Metabolite levels (X-11787); BRCA cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg05283184 chr6:79620031 NA -0.45 -11.42 -0.41 1.26e-27 Intelligence (multi-trait analysis); BRCA cis rs9467711 0.606 rs34781270 chr6:26593037 A/G cg12826209 chr6:26865740 GUSBL1 0.73 7.8 0.3 2.44e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs2797160 1.000 rs1739357 chr6:126019655 T/G cg05901451 chr6:126070800 HEY2 0.42 10.25 0.38 6.55e-23 Endometrial cancer; BRCA cis rs4595586 0.545 rs1319791 chr12:39372486 G/T cg26384229 chr12:38710491 ALG10B 0.55 11.69 0.42 9.17e-29 Morning vs. evening chronotype; BRCA cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg00677455 chr12:58241039 CTDSP2 0.63 14.45 0.5 3.74e-41 Multiple sclerosis; BRCA cis rs4690686 0.500 rs4690688 chr4:177264192 G/C cg17059388 chr4:177262070 NA 0.51 10.68 0.39 1.34e-24 Essential tremor; BRCA cis rs7903847 0.642 rs11817875 chr10:99158414 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.41 -0.32 2.58e-16 Granulocyte percentage of myeloid white cells; BRCA trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21659725 chr3:3221576 CRBN 0.71 21.66 0.65 1.89e-78 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg10556349 chr10:835070 NA 0.63 9.21 0.34 4.66e-19 Eosinophil percentage of granulocytes; BRCA cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.72 11.14 0.4 1.79e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.789 rs9991166 chr4:120237851 G/A cg25214090 chr10:38739885 LOC399744 0.44 10.29 0.38 4.34e-23 Corneal astigmatism; BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 21.11 0.64 1.86e-75 Platelet count; BRCA cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.81 12.37 0.44 1.14e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs9944715 0.954 rs8098751 chr18:43850587 G/A cg01718231 chr17:29326311 RNF135 -0.43 -8.63 -0.32 4.74e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs6963495 0.818 rs6956249 chr7:105149743 A/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.07e-19 Bipolar disorder (body mass index interaction); BRCA cis rs10751667 0.580 rs7396041 chr11:1001607 G/A cg01483505 chr11:975446 AP2A2 0.3 8.18 0.31 1.56e-15 Alzheimer's disease (late onset); BRCA cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg13319975 chr6:146136371 FBXO30 -0.44 -10.1 -0.37 2.4e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg26647111 chr11:31128758 NA 0.45 9.64 0.36 1.25e-20 Red blood cell count; BRCA cis rs1865760 0.515 rs2003208 chr6:25940719 G/C cg12310025 chr6:25882481 NA -0.37 -8.67 -0.32 3.5e-17 Height; BRCA cis rs7103648 0.742 rs34937994 chr11:47389638 C/T cg20307385 chr11:47447363 PSMC3 0.82 20.84 0.64 5.25e-74 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2243480 0.803 rs55700941 chr7:65389800 T/A cg18252515 chr7:66147081 NA -0.91 -13.01 -0.46 1.64e-34 Diabetic kidney disease; BRCA cis rs9868809 0.505 rs9811027 chr3:48725014 G/C cg01304814 chr3:48885189 PRKAR2A 0.56 7.84 0.3 1.89e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA trans rs6952808 0.723 rs4721264 chr7:2012997 G/A cg04565464 chr8:145669602 NFKBIL2 0.39 9.02 0.34 2.23e-18 Bipolar disorder and schizophrenia; BRCA cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.03e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg03146154 chr1:46216737 IPP 0.45 10.2 0.37 9.86e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg04025307 chr7:1156635 C7orf50 0.59 9.36 0.35 1.38e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10911251 0.546 rs944971 chr1:183112505 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA cis rs17818399 0.547 rs12997164 chr2:46758746 A/C cg02822958 chr2:46747628 ATP6V1E2 0.56 10.74 0.39 7.62e-25 Height; BRCA cis rs1832871 0.672 rs9457363 chr6:158777515 C/T cg07165851 chr6:158734300 TULP4 0.63 12.97 0.46 2.46e-34 Height; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg03188948 chr7:1209495 NA 0.68 14.5 0.5 2.22e-41 Longevity;Endometriosis; BRCA cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg05535760 chr7:792225 HEATR2 0.72 13.37 0.47 4.09e-36 Cerebrospinal P-tau181p levels; BRCA cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg18132916 chr6:79620363 NA -0.4 -8.09 -0.3 2.92e-15 Intelligence (multi-trait analysis); BRCA cis rs4642101 0.765 rs3901665 chr3:12824610 C/A cg24848339 chr3:12840334 CAND2 0.43 11.4 0.41 1.62e-27 QRS complex (12-leadsum); BRCA cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg21918786 chr6:109611834 NA -0.49 -14.34 -0.49 1.27e-40 Reticulocyte fraction of red cells; BRCA cis rs11971779 0.680 rs7783619 chr7:139061437 G/A cg07862535 chr7:139043722 LUC7L2 0.37 9.94 0.37 9.2e-22 Diisocyanate-induced asthma; BRCA cis rs6088590 1.000 rs6119530 chr20:33403930 A/G cg06115741 chr20:33292138 TP53INP2 0.52 11.78 0.42 3.81e-29 Coronary artery disease; BRCA cis rs2070997 0.667 rs10901291 chr9:133717881 C/T cg11464064 chr9:133710261 ABL1 0.53 9.6 0.35 1.81e-20 Response to amphetamines; BRCA cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg17420585 chr12:42539391 GXYLT1 -0.38 -8.1 -0.31 2.77e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg04450456 chr4:17643702 FAM184B 0.37 10.78 0.39 5.4e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs629535 0.814 rs62513376 chr8:70086881 C/T cg21567404 chr3:27674614 NA -1.01 -21.11 -0.64 1.93e-75 Dupuytren's disease; BRCA cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg05234568 chr11:5960015 NA -0.49 -9.9 -0.36 1.37e-21 DNA methylation (variation); BRCA cis rs829883 0.659 rs11109520 chr12:98928646 C/T cg25150519 chr12:98850993 NA 0.5 9.15 0.34 7.65e-19 Colorectal adenoma (advanced); BRCA cis rs12477438 0.520 rs8179690 chr2:99795300 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.87 -28.25 -0.75 1.44e-114 Chronic sinus infection; BRCA cis rs7617773 0.780 rs11714176 chr3:48360862 C/T cg11946769 chr3:48343235 NME6 0.7 14.13 0.49 1.21e-39 Coronary artery disease; BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg11766577 chr21:47581405 C21orf56 -0.5 -10.8 -0.39 4.3e-25 Testicular germ cell tumor; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg26608667 chr7:1196370 ZFAND2A 0.37 8.21 0.31 1.21e-15 Longevity;Endometriosis; BRCA cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg10932868 chr11:921992 NA 0.5 12.89 0.45 5.66e-34 Alzheimer's disease (late onset); BRCA trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg11707556 chr5:10655725 ANKRD33B 0.4 9.63 0.36 1.32e-20 Coronary artery disease; BRCA cis rs9810890 1.000 rs114261227 chr3:128469760 A/C cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs7914558 1.000 rs7920251 chr10:104950197 C/T cg04362960 chr10:104952993 NT5C2 0.41 9.78 0.36 3.87e-21 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs10870270 1.000 rs7098014 chr10:133775029 G/A cg08754478 chr10:133766260 PPP2R2D -0.68 -14.18 -0.49 7.24e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs700651 0.789 rs62277902 chr2:198879443 T/A cg00792783 chr2:198669748 PLCL1 -0.44 -9.4 -0.35 9.6e-20 Intracranial aneurysm; BRCA cis rs17270561 0.609 rs2154218 chr6:25776290 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.61 0.36 1.67e-20 Iron status biomarkers; BRCA cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.27 0.34 2.86e-19 Height; BRCA cis rs7582180 0.739 rs11687352 chr2:100919888 A/C cg14675211 chr2:100938903 LONRF2 0.47 10.81 0.39 3.94e-25 Intelligence (multi-trait analysis); BRCA cis rs2806561 0.704 rs6426779 chr1:23310485 T/C cg19743168 chr1:23544995 NA -0.41 -9.78 -0.36 3.87e-21 Height; BRCA cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg15017067 chr4:17643749 FAM184B -0.27 -7.98 -0.3 6.66e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs4074536 0.574 rs10801968 chr1:116287055 C/T cg21648376 chr1:116311395 CASQ2 -0.48 -8.43 -0.32 2.24e-16 QRS duration; BRCA cis rs4595586 0.545 rs925829 chr12:39364167 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.41 0.35 8.87e-20 Morning vs. evening chronotype; BRCA cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg16102102 chr5:83017553 HAPLN1 -0.7 -15.6 -0.53 9.66e-47 Prostate cancer; BRCA cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg01689657 chr7:91764605 CYP51A1 0.21 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.16 0.31 1.74e-15 Aortic root size; BRCA cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg00677455 chr12:58241039 CTDSP2 0.56 12.8 0.45 1.56e-33 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.902 rs973855 chr6:145781850 C/T cg23711669 chr6:146136114 FBXO30 -0.62 -14.17 -0.49 7.89e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg01874867 chr7:94954059 PON1 -0.4 -8.17 -0.31 1.6e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6840360 0.550 rs62327267 chr4:152518753 G/T cg22705602 chr4:152727874 NA -0.32 -8.3 -0.31 6.2e-16 Intelligence (multi-trait analysis); BRCA cis rs2839186 0.933 rs56955294 chr21:47708953 A/G cg12379764 chr21:47803548 PCNT -0.37 -7.84 -0.3 1.84e-14 Testicular germ cell tumor; BRCA cis rs12545109 0.800 rs970838 chr8:57414806 A/G cg09654669 chr8:57350985 NA -0.39 -8.4 -0.32 2.82e-16 Obesity-related traits; BRCA cis rs2882667 0.824 rs11748097 chr5:138479887 C/A cg04439458 chr5:138467593 SIL1 -0.44 -11.11 -0.4 2.38e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs758324 0.947 rs10054618 chr5:131195002 C/T cg06307176 chr5:131281290 NA 0.54 10.46 0.38 9.95e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg22875332 chr1:76189707 ACADM 0.79 18.77 0.6 6.1e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg06698575 chr12:117470875 NA 0.45 7.99 0.3 6.34e-15 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg05868516 chr6:26286170 HIST1H4H 0.5 11.25 0.41 6.6e-27 Educational attainment; BRCA cis rs13315871 0.929 rs13075746 chr3:58293867 G/A cg20936604 chr3:58311152 NA -0.66 -8.47 -0.32 1.65e-16 Cholesterol, total; BRCA cis rs9287719 0.837 rs4233883 chr2:10755596 A/G cg00105475 chr2:10696890 NA 0.45 10.36 0.38 2.42e-23 Prostate cancer; BRCA cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg16405210 chr4:1374714 KIAA1530 -0.51 -11.97 -0.43 5.95e-30 Longevity; BRCA cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg18876405 chr7:65276391 NA 0.71 18.64 0.59 3.12e-62 Aortic root size; BRCA cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 29.81 0.76 4.96e-123 Chronic sinus infection; BRCA cis rs9790314 0.663 rs796609 chr3:160705600 C/G cg03342759 chr3:160939853 NMD3 -0.46 -8.83 -0.33 1.02e-17 Morning vs. evening chronotype; BRCA cis rs9649465 1.000 rs13224762 chr7:123370710 A/G cg04330084 chr7:123175371 IQUB -0.33 -8.98 -0.33 2.94e-18 Migraine; BRCA cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg11663144 chr21:46675770 NA -0.59 -13.83 -0.48 3.07e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2012796 0.743 rs61986598 chr14:81856865 G/A cg02996355 chr14:81879375 NA 0.53 10.57 0.39 3.58e-24 Night sleep phenotypes; BRCA cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg16414030 chr3:133502952 NA 0.44 10.65 0.39 1.77e-24 Iron status biomarkers; BRCA cis rs10788264 0.569 rs10749454 chr10:124029654 C/T cg09507567 chr10:124027408 NA 0.41 8.94 0.33 4.15e-18 Total body bone mineral density; BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg00149659 chr3:10157352 C3orf10 1.06 17.88 0.58 2.77e-58 Alzheimer's disease; BRCA trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg26384229 chr12:38710491 ALG10B 0.58 13.2 0.46 2.25e-35 Morning vs. evening chronotype; BRCA cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg19920283 chr7:105172520 RINT1 -0.58 -9.82 -0.36 2.83e-21 Bipolar disorder (body mass index interaction); BRCA cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg08645402 chr16:4508243 NA 0.43 10.04 0.37 4.09e-22 Schizophrenia; BRCA cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg00898013 chr13:113819073 PROZ -0.36 -8.64 -0.32 4.44e-17 Platelet distribution width; BRCA cis rs7666738 0.791 rs11730069 chr4:98945772 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg07930192 chr7:1003750 NA 0.41 8.81 0.33 1.18e-17 Longevity;Endometriosis; BRCA cis rs6087990 0.769 rs17123658 chr20:31390840 C/A cg13636640 chr20:31349939 DNMT3B 0.62 18.59 0.59 5.53e-62 Ulcerative colitis; BRCA cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24110177 chr3:50126178 RBM5 -0.4 -10.86 -0.39 2.6e-25 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.791 rs7765675 chr6:145915077 A/C cg23711669 chr6:146136114 FBXO30 0.79 18.95 0.6 6.68e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs8180040 0.966 rs3736177 chr3:47451411 C/T cg16586182 chr3:47516702 SCAP 0.65 14.86 0.51 4.2e-43 Colorectal cancer; BRCA cis rs13191362 1.000 rs35044651 chr6:163004142 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.07e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg21399703 chr1:247681439 NA 0.42 9.37 0.35 1.22e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.08 -0.3 3.26e-15 Total body bone mineral density; BRCA trans rs11098499 0.909 rs28714195 chr4:120316950 A/T cg25214090 chr10:38739885 LOC399744 0.52 12.14 0.43 1.21e-30 Corneal astigmatism; BRCA cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.42 0.5 5.06e-41 Personality dimensions; BRCA cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14240646 chr10:27532245 ACBD5 0.56 9.46 0.35 5.99e-20 Breast cancer; BRCA cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg12310025 chr6:25882481 NA -0.5 -11.19 -0.4 1.16e-26 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg14820908 chr5:178986412 RUFY1 -0.45 -11.91 -0.43 1.07e-29 Lung cancer; BRCA cis rs1965732 0.588 rs13385033 chr2:3715071 C/T cg19052272 chr2:3704530 ALLC -0.32 -7.88 -0.3 1.45e-14 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs8180040 0.966 rs6792488 chr3:47503349 C/T cg16586182 chr3:47516702 SCAP 0.65 15.17 0.51 1.34e-44 Colorectal cancer; BRCA cis rs9814567 1.000 rs1880377 chr3:134270468 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg22903471 chr2:27725779 GCKR -0.39 -9.44 -0.35 6.93e-20 Total body bone mineral density; BRCA trans rs9858542 0.953 rs3811697 chr3:49590770 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.55 -0.35 2.75e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6450176 0.951 rs5013866 chr5:53300947 A/G ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg20573242 chr4:122745356 CCNA2 0.49 10.86 0.39 2.41e-25 Type 2 diabetes; BRCA cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg23711669 chr6:146136114 FBXO30 0.76 17.88 0.58 2.71e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.579 rs1780137 chr10:38501475 C/G cg25427524 chr10:38739819 LOC399744 -0.73 -17.48 -0.57 3.1e-56 Extrinsic epigenetic age acceleration; BRCA cis rs1707322 1.000 rs10890365 chr1:46359348 C/T cg06784218 chr1:46089804 CCDC17 0.44 10.61 0.39 2.5300000000000002e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg14169450 chr9:139327907 INPP5E -0.46 -11.07 -0.4 3.65e-26 Monocyte percentage of white cells; BRCA cis rs208520 0.802 rs1342959 chr6:66883329 A/G cg07460842 chr6:66804631 NA -0.95 -17.73 -0.57 1.73e-57 Exhaled nitric oxide output; BRCA cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg00071950 chr4:10020882 SLC2A9 0.66 16.62 0.55 7.62e-52 Bone mineral density; BRCA cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg25251562 chr2:3704773 ALLC 0.42 8.34 0.31 4.45e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg12165864 chr7:66369176 NA -0.46 -10.44 -0.38 1.13e-23 Corneal structure; BRCA cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg05896524 chr21:47604654 C21orf56 0.44 8.91 0.33 5.08e-18 Testicular germ cell tumor; BRCA cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg05283184 chr6:79620031 NA -0.42 -10.83 -0.39 3.4e-25 Intelligence (multi-trait analysis); BRCA cis rs12618769 0.597 rs3769730 chr2:99101453 T/C cg10123293 chr2:99228465 UNC50 0.42 8.18 0.31 1.53e-15 Bipolar disorder; BRCA cis rs2549003 1.000 rs2549007 chr5:131826875 T/C cg21138405 chr5:131827807 IRF1 -0.4 -13.19 -0.46 2.66e-35 Asthma (sex interaction); BRCA cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg26384229 chr12:38710491 ALG10B 0.82 21.71 0.65 1.09e-78 Heart rate; BRCA cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg00012203 chr2:219082015 ARPC2 -0.49 -9.44 -0.35 6.57e-20 Colorectal cancer; BRCA cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs16958440 0.867 rs12386092 chr18:44672058 C/T cg17192377 chr18:44677553 HDHD2 0.99 13.87 0.48 1.94e-38 Sitting height ratio; BRCA cis rs10751667 1.000 rs10751667 chr11:941941 A/T ch.11.42038R chr11:967971 AP2A2 0.56 17.82 0.58 5.73e-58 Alzheimer's disease (late onset); BRCA cis rs6060717 0.536 rs6060683 chr20:34507921 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.12 -0.31 2.41e-15 Hip circumference adjusted for BMI; BRCA cis rs4891159 0.548 rs660342 chr18:74130896 C/G cg24786174 chr18:74118243 ZNF516 0.83 25.27 0.71 3.13e-98 Longevity; BRCA cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg15556689 chr8:8085844 FLJ10661 0.46 13.24 0.46 1.58e-35 Mood instability; BRCA cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg21724239 chr8:58056113 NA 0.59 9.59 0.35 1.92e-20 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26314531 chr2:26401878 FAM59B 0.82 11.83 0.42 2.55e-29 Gut microbiome composition (summer); BRCA cis rs8180040 0.966 rs59586735 chr3:47518325 C/T cg16586182 chr3:47516702 SCAP 0.65 15.21 0.52 8.39e-45 Colorectal cancer; BRCA cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg18876405 chr7:65276391 NA 0.53 12.29 0.44 2.69e-31 Aortic root size; BRCA cis rs9283706 0.689 rs6889240 chr5:66320940 A/G cg11590213 chr5:66331682 MAST4 0.43 8.19 0.31 1.4e-15 Coronary artery disease; BRCA cis rs9470366 0.883 rs7756236 chr6:36627053 A/G cg08179530 chr6:36648295 CDKN1A 0.49 9.7 0.36 7.77e-21 QRS duration; BRCA cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg00750074 chr16:89608354 SPG7 -0.39 -10.31 -0.38 3.81e-23 Multiple myeloma (IgH translocation); BRCA cis rs11051970 0.877 rs2651360 chr12:32588920 C/T cg24626660 chr12:32551988 NA 0.29 8.22 0.31 1.14e-15 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs10242455 0.702 rs55927283 chr7:99057191 G/C cg09045935 chr12:6379348 NA 0.89 9.35 0.35 1.43e-19 Blood metabolite levels; BRCA cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg23029597 chr12:123009494 RSRC2 0.53 10.92 0.4 1.5e-25 Body mass index; BRCA cis rs11622475 1.000 rs8021692 chr14:104428576 C/G cg12183467 chr14:104352244 NA -0.46 -9.24 -0.34 3.5e-19 Bipolar disorder; BRCA cis rs7246657 0.722 rs13744 chr19:38077912 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg21143896 chr7:2802374 GNA12 -0.35 -8.61 -0.32 5.65e-17 Height; BRCA cis rs13082711 0.522 rs574955 chr3:27351000 T/C cg02860705 chr3:27208620 NA 0.43 8.84 0.33 8.89e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs4363385 0.818 rs2711 chr1:153005156 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.18 0.77 5e-125 Chronic sinus infection; BRCA trans rs7829975 0.624 rs7823056 chr8:8382705 A/G cg21775007 chr8:11205619 TDH 0.4 8.52 0.32 1.15e-16 Mood instability; BRCA cis rs4865169 0.783 rs7668814 chr4:57825190 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.41 -8.57 -0.32 7.88e-17 Breast cancer; BRCA cis rs897080 0.515 rs1067343 chr2:44621042 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.54 10.43 0.38 1.2e-23 Height; BRCA cis rs2535633 0.631 rs9823697 chr3:53002150 A/G cg11645453 chr3:52864694 ITIH4 0.38 10.08 0.37 2.83e-22 Body mass index; BRCA cis rs2797160 1.000 rs6910933 chr6:126017155 C/G cg05901451 chr6:126070800 HEY2 0.39 9.52 0.35 3.54e-20 Endometrial cancer; BRCA cis rs11098499 0.874 rs12509054 chr4:120115075 A/C cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.65e-26 Corneal astigmatism; BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg11843238 chr5:131593191 PDLIM4 0.34 8.98 0.33 3.01e-18 Breast cancer; BRCA cis rs11955398 0.563 rs1816864 chr5:60011273 T/C cg02684056 chr5:59996105 DEPDC1B -0.37 -9.04 -0.34 1.9e-18 Intelligence (multi-trait analysis); BRCA cis rs16867321 0.950 rs4667228 chr2:181498824 T/A cg23363182 chr2:181467187 NA -0.44 -8.32 -0.31 5.39e-16 Obesity; BRCA cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg05340658 chr4:99064831 C4orf37 0.63 15.05 0.51 5.01e-44 Colonoscopy-negative controls vs population controls; BRCA trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg01620082 chr3:125678407 NA -0.86 -10.28 -0.38 4.77e-23 Intelligence (multi-trait analysis); BRCA cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg10523679 chr1:76189770 ACADM -0.77 -15.65 -0.53 5.97e-47 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs11098499 0.955 rs1511015 chr4:120170473 A/C cg25214090 chr10:38739885 LOC399744 0.48 10.62 0.39 2.18e-24 Corneal astigmatism; BRCA cis rs3772130 0.962 rs6784571 chr3:121539991 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.91 0.4 1.52e-25 Cognitive performance; BRCA cis rs2625529 0.824 rs12916951 chr15:72252498 C/T cg16672083 chr15:72433130 SENP8 -0.79 -17.0 -0.56 9.9e-54 Red blood cell count; BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.41 8.32 0.31 5.44e-16 Tonsillectomy; BRCA cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg08392591 chr16:89556376 ANKRD11 0.37 8.85 0.33 8.58e-18 Multiple myeloma (IgH translocation); BRCA cis rs939658 0.967 rs7172074 chr15:79452726 T/C cg17916960 chr15:79447300 NA 0.39 9.82 0.36 2.73e-21 Refractive error; BRCA cis rs832540 0.801 rs7731700 chr5:56111927 C/T cg24531977 chr5:56204891 C5orf35 -0.47 -9.64 -0.36 1.27e-20 Coronary artery disease; BRCA cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg17971929 chr21:40555470 PSMG1 0.82 19.79 0.62 2.45e-68 Cognitive function; BRCA cis rs9814567 1.000 rs9871305 chr3:134213538 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.44 -0.32 2.09e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4302748 0.818 rs11771125 chr7:36190426 C/T cg24442661 chr7:36192818 EEPD1 0.51 9.24 0.34 3.65e-19 Platelet count; BRCA cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg03146154 chr1:46216737 IPP 0.53 11.73 0.42 6.59e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2046867 0.661 rs9861834 chr3:72909272 C/T cg25664220 chr3:72788482 NA -0.44 -10.34 -0.38 2.77e-23 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs3008870 1.000 rs12137403 chr1:67437043 C/T cg08660285 chr1:67390436 MIER1;WDR78 -1.0 -22.82 -0.67 9.01e-85 Lymphocyte percentage of white cells; BRCA cis rs7520050 0.807 rs5021934 chr1:46109304 A/G cg24296786 chr1:45957014 TESK2 0.46 10.77 0.39 5.78e-25 Red blood cell count;Reticulocyte count; BRCA cis rs1941023 0.503 rs4528348 chr11:60129505 C/G cg08716584 chr11:60157161 MS4A7 -0.42 -9.83 -0.36 2.58e-21 Congenital heart disease (maternal effect); BRCA trans rs6598955 0.950 rs6700455 chr1:26545864 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.38 -9.56 -0.35 2.57e-20 Obesity-related traits; BRCA cis rs2463822 1.000 rs2513747 chr11:62098735 T/C cg06239285 chr11:62104954 ASRGL1 0.67 11.13 0.4 1.92e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -16.23 -0.54 7.49e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg07092213 chr7:1199455 ZFAND2A -0.42 -8.43 -0.32 2.28e-16 Longevity;Endometriosis; BRCA cis rs7927771 0.507 rs12366244 chr11:47882130 C/A cg20307385 chr11:47447363 PSMC3 0.42 9.46 0.35 5.68e-20 Subjective well-being; BRCA trans rs61931739 0.500 rs7979240 chr12:34509026 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.66 0.36 1.08e-20 Morning vs. evening chronotype; BRCA cis rs2249625 0.844 rs2496515 chr6:72905741 C/T cg18830697 chr6:72922368 RIMS1 0.4 8.51 0.32 1.2e-16 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg06022373 chr22:39101656 GTPBP1 0.71 16.3 0.54 3.39e-50 Menopause (age at onset); BRCA cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.09 -0.34 1.23e-18 Developmental language disorder (linguistic errors); BRCA cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.3 -0.31 6.03e-16 Colorectal cancer; BRCA cis rs36051895 0.664 rs17425637 chr9:5110000 C/T cg02405213 chr9:5042618 JAK2 -0.49 -9.12 -0.34 1e-18 Pediatric autoimmune diseases; BRCA cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg25358565 chr5:93447407 FAM172A 1.23 18.9 0.6 1.26e-63 Diabetic retinopathy; BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg01262667 chr19:19385393 TM6SF2 0.4 10.33 0.38 3.12e-23 Tonsillectomy; BRCA cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg23711669 chr6:146136114 FBXO30 -0.78 -18.65 -0.59 2.56e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.623 rs4882302 chr12:38415608 T/A cg26384229 chr12:38710491 ALG10B -0.43 -9.86 -0.36 1.91e-21 Bladder cancer; BRCA cis rs17401966 0.931 rs11587854 chr1:10447622 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.14 -0.31 2.12e-15 Hepatocellular carcinoma; BRCA cis rs3784262 0.528 rs6493979 chr15:58338052 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.42 -0.35 7.79e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11030122 0.702 rs1452047 chr11:3991648 A/C cg18678763 chr11:4115507 RRM1 -0.36 -8.06 -0.3 3.85e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs2249625 1.000 rs2249625 chr6:72906753 C/T cg18830697 chr6:72922368 RIMS1 0.41 8.81 0.33 1.21e-17 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs9868809 0.881 rs34368826 chr3:48670827 G/T cg00383909 chr3:49044727 WDR6 0.55 8.38 0.31 3.29e-16 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg09184832 chr6:79620586 NA 0.48 10.95 0.4 1.13e-25 Intelligence (multi-trait analysis); BRCA cis rs1904096 0.506 rs10024642 chr4:95179295 A/G cg11021082 chr4:95130006 SMARCAD1 -0.39 -8.21 -0.31 1.25e-15 Type 2 diabetes; BRCA cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.55 0.39 4.28e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs2832077 0.527 rs9981922 chr21:30212718 A/G cg14791747 chr16:20752902 THUMPD1 0.45 14.23 0.49 4.17e-40 Cognitive test performance; BRCA cis rs2011503 0.941 rs998732 chr19:19378671 A/G cg11584989 chr19:19387371 SF4 0.67 14.73 0.5 1.78e-42 Bipolar disorder; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg24642844 chr7:1081250 C7orf50 -0.88 -16.14 -0.54 2.03e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg25517755 chr10:38738941 LOC399744 -0.37 -7.88 -0.3 1.45e-14 Corneal astigmatism; BRCA cis rs7677751 0.806 rs7679903 chr4:55097373 T/C cg17187183 chr4:55093834 PDGFRA 0.44 9.06 0.34 1.53e-18 Corneal astigmatism; BRCA cis rs7824557 0.933 rs6601576 chr8:11100275 A/T cg21775007 chr8:11205619 TDH -0.45 -8.78 -0.33 1.51e-17 Retinal vascular caliber; BRCA cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg08477640 chr19:41863820 B9D2 -0.39 -8.09 -0.3 3.02e-15 Migraine;Coronary artery disease; BRCA cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg27446573 chr6:127587934 RNF146 0.69 15.88 0.53 4e-48 Breast cancer; BRCA cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.79 19.13 0.6 7.56e-65 Multiple sclerosis; BRCA cis rs9818758 0.607 rs11710247 chr3:49249800 G/T cg00383909 chr3:49044727 WDR6 0.73 12.61 0.45 1.01e-32 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs6901250 0.851 rs339313 chr6:117179501 C/T cg12892004 chr6:117198278 RFX6 -0.5 -11.41 -0.41 1.44e-27 C-reactive protein levels; BRCA cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg12011299 chr4:100065546 ADH4 0.43 11.44 0.41 1.09e-27 Alcohol dependence; BRCA cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg16386425 chr10:429943 DIP2C -0.42 -8.96 -0.33 3.49e-18 Psychosis in Alzheimer's disease; BRCA cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg11057378 chr10:81107060 PPIF 0.43 10.16 0.37 1.35e-22 Height; BRCA cis rs887829 0.588 rs4663971 chr2:234674252 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.31 -8.28 -0.31 7.13e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs2147904 0.934 rs783629 chr1:42363275 C/T cg16685388 chr1:42384056 HIVEP3 0.32 8.92 0.33 5.06e-18 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg10495392 chr1:46806563 NSUN4 0.47 8.53 0.32 1.06e-16 Menopause (age at onset); BRCA cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg06108461 chr20:60628389 TAF4 -0.98 -22.38 -0.66 2.42e-82 Body mass index; BRCA trans rs941408 1.000 rs1076447 chr19:2792128 C/G cg19676328 chr12:49525230 TUBA1B -0.53 -11.61 -0.42 2.02e-28 Total cholesterol levels; BRCA cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.52 -0.44 2.53e-32 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg10556349 chr10:835070 NA 0.6 8.41 0.32 2.75e-16 Eosinophil percentage of granulocytes; BRCA cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg08000102 chr2:233561755 GIGYF2 -0.55 -11.28 -0.41 4.77e-27 Coronary artery disease; BRCA cis rs11696845 0.626 rs6073537 chr20:43378270 A/G cg25301532 chr20:43378953 KCNK15 -0.43 -10.27 -0.38 5.38e-23 Obesity-related traits; BRCA cis rs853679 0.517 rs9393895 chr6:28127621 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.13 0.31 2.27e-15 Depression; BRCA cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg20203395 chr5:56204925 C5orf35 0.64 12.65 0.45 6.77e-33 Initial pursuit acceleration; BRCA cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg02297831 chr4:17616191 MED28 -0.34 -7.91 -0.3 1.11e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4594175 0.926 rs9323207 chr14:51621908 A/G cg23942311 chr14:51606299 NA -0.32 -8.26 -0.31 8.64e-16 Cancer; BRCA cis rs66887589 0.777 rs4643791 chr4:120265619 A/G cg09307838 chr4:120376055 NA -0.46 -9.91 -0.36 1.29e-21 Diastolic blood pressure; BRCA cis rs6964587 0.934 rs6465344 chr7:91640273 G/A cg17063962 chr7:91808500 NA 0.56 13.38 0.47 3.55e-36 Breast cancer; BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg18402987 chr7:1209562 NA 0.66 11.36 0.41 2.29e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17401966 1.000 rs6700866 chr1:10306038 A/G cg15208524 chr1:10270712 KIF1B 0.37 8.19 0.31 1.41e-15 Hepatocellular carcinoma; BRCA cis rs7103648 0.695 rs11039290 chr11:47572279 G/A cg03711944 chr11:47377212 SPI1 -0.41 -9.76 -0.36 4.42e-21 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs3815700 1.000 rs8104729 chr19:33093979 C/T cg02997394 chr19:33096574 ANKRD27 0.69 11.52 0.41 4.75e-28 Eosinophilic esophagitis; BRCA cis rs758324 0.947 rs6596039 chr5:131198652 C/A cg06307176 chr5:131281290 NA 0.53 10.32 0.38 3.51e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg03517284 chr6:25882590 NA -0.51 -11.51 -0.41 5.28e-28 Blood metabolite levels; BRCA cis rs801193 0.569 rs7800620 chr7:66223688 T/C cg18876405 chr7:65276391 NA 0.48 10.7 0.39 1.12e-24 Aortic root size; BRCA cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.39 -0.32 3.06e-16 Monocyte percentage of white cells; BRCA cis rs4363385 0.818 rs574649 chr1:153008471 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA trans rs11098499 0.629 rs28369518 chr4:120271630 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.64 0.39 1.93e-24 Corneal astigmatism; BRCA cis rs1829883 1.000 rs2460683 chr5:98778568 A/G cg08333243 chr5:99726346 NA -0.37 -8.79 -0.33 1.33e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg23583168 chr7:148888333 NA -0.83 -18.73 -0.6 9.66e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs921943 0.554 rs163132 chr5:78285921 A/G cg11541897 chr5:78281793 ARSB 0.42 8.83 0.33 1e-17 Blood and toenail selenium levels;Blood trace element (Se levels); BRCA cis rs11098499 0.691 rs28396837 chr4:120271541 G/A cg09307838 chr4:120376055 NA 0.6 13.04 0.46 1.24e-34 Corneal astigmatism; BRCA cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg06627628 chr2:24431161 ITSN2 -0.56 -9.03 -0.34 1.94e-18 Lymphocyte counts; BRCA cis rs4728302 0.838 rs10225115 chr7:133591435 C/T cg07491979 chr7:133331646 EXOC4 0.36 7.82 0.3 2.17e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs4481887 0.861 rs4295906 chr1:248429861 C/T cg13385794 chr1:248469461 NA 0.28 7.88 0.3 1.4e-14 Common traits (Other); BRCA cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg11266682 chr4:10021025 SLC2A9 0.39 10.36 0.38 2.45e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg05313129 chr8:58192883 C8orf71 -0.43 -8.88 -0.33 6.55e-18 Developmental language disorder (linguistic errors); BRCA cis rs736801 0.808 rs4705950 chr5:131793286 C/T cg07395648 chr5:131743802 NA -0.39 -8.88 -0.33 6.54e-18 Breast cancer;Mosquito bite size; BRCA cis rs1891275 0.515 rs7093728 chr10:93443617 C/T cg07889827 chr10:93443413 NA -0.44 -12.37 -0.44 1.2e-31 Intelligence (multi-trait analysis); BRCA cis rs57590327 0.508 rs10511101 chr3:81950302 A/C cg07356753 chr3:81810745 GBE1 -0.36 -8.46 -0.32 1.8e-16 Extraversion; BRCA cis rs11098499 0.863 rs13140409 chr4:120503460 A/G cg09307838 chr4:120376055 NA 0.69 13.91 0.48 1.24e-38 Corneal astigmatism; BRCA cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg06766960 chr11:133703094 NA -0.63 -13.39 -0.47 3.35e-36 Childhood ear infection; BRCA cis rs11191419 1 rs11191419 chr10:104612335 T/A cg04362960 chr10:104952993 NT5C2 0.44 10.47 0.38 8.45e-24 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs6963495 0.818 rs73192120 chr7:105171156 C/T cg19920283 chr7:105172520 RINT1 0.59 9.53 0.35 3.29e-20 Bipolar disorder (body mass index interaction); BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg13397359 chr6:42928475 GNMT 0.76 19.52 0.61 6.66e-67 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.662 rs448725 chr7:65514628 A/G cg18876405 chr7:65276391 NA 0.58 13.95 0.48 8.13e-39 Aortic root size; BRCA cis rs3008870 0.755 rs4486425 chr1:67460791 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.64 -14.13 -0.49 1.19e-39 Lymphocyte percentage of white cells; BRCA cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 13.72 0.48 1.02e-37 Colorectal cancer; BRCA cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg26384229 chr12:38710491 ALG10B -0.62 -15.08 -0.51 3.43e-44 Drug-induced liver injury (flucloxacillin); BRCA cis rs7568458 0.783 rs2166529 chr2:85742175 A/C cg02493740 chr2:85810744 VAMP5 0.39 8.21 0.31 1.19e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg20701182 chr2:24300061 SF3B14 0.66 9.65 0.36 1.17e-20 Lymphocyte percentage of white cells; BRCA cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 11.31 0.41 3.62e-27 Systemic lupus erythematosus; BRCA cis rs7000551 0.689 rs12545909 chr8:22310052 A/G cg12081754 chr8:22256438 SLC39A14 -0.44 -8.63 -0.32 4.93e-17 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs838147 0.505 rs1688264 chr19:49209560 T/G cg07051648 chr19:49177693 NTN5;SEC1 -0.42 -8.02 -0.3 5.01e-15 Dietary macronutrient intake; BRCA cis rs2832191 0.791 rs2832202 chr21:30501342 G/A cg08807101 chr21:30365312 RNF160 -0.58 -14.35 -0.49 1.13e-40 Dental caries; BRCA cis rs61990749 0.597 rs176944 chr14:78176211 G/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.03 -0.37 4.19e-22 Fibroblast growth factor basic levels; BRCA cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg18850127 chr7:39170497 POU6F2 0.52 11.68 0.42 1.02e-28 IgG glycosylation; BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg00814883 chr7:100076585 TSC22D4 -0.54 -11.63 -0.42 1.77e-28 Platelet count; BRCA cis rs8032158 1.000 rs11633313 chr15:56135709 A/G cg02198044 chr15:56286336 NEDD4 -0.39 -9.24 -0.34 3.65e-19 Keloid; BRCA cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.64 0.36 1.22e-20 Motion sickness; BRCA cis rs13046373 0.508 rs1911572 chr21:32031648 A/G cg16431978 chr21:31797932 KRTAP13-3 -0.36 -9.14 -0.34 8.12e-19 HDL cholesterol; BRCA cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg10802521 chr3:52805072 NEK4 -0.34 -9.33 -0.35 1.71e-19 Bipolar disorder; BRCA cis rs7267979 0.714 rs6132825 chr20:25238309 A/T cg08601574 chr20:25228251 PYGB 0.39 9.36 0.35 1.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs870825 0.655 rs28555435 chr4:185647300 C/A cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs1256061 0.654 rs1256033 chr14:64745399 A/G cg23250157 chr14:64679961 SYNE2 0.29 7.84 0.3 1.9e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg11814155 chr7:99998594 ZCWPW1 0.48 8.49 0.32 1.47e-16 Platelet count; BRCA cis rs875971 0.862 rs949930 chr7:65766822 C/G cg18876405 chr7:65276391 NA -0.5 -11.54 -0.42 3.9e-28 Aortic root size; BRCA trans rs7618501 0.602 rs2301166 chr3:50148305 C/G cg21659725 chr3:3221576 CRBN -0.47 -11.96 -0.43 6.89e-30 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg16339924 chr4:17578868 LAP3 0.58 14.13 0.49 1.17e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1577917 0.958 rs12209259 chr6:86502348 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.04 -0.43 3.04e-30 Response to antipsychotic treatment; BRCA cis rs11190604 1.000 rs35106985 chr10:102307542 T/C cg07080220 chr10:102295463 HIF1AN 0.65 15.39 0.52 1.04e-45 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg12311346 chr5:56204834 C5orf35 -0.81 -16.16 -0.54 1.71e-49 Initial pursuit acceleration; BRCA trans rs11976180 1.000 rs67239267 chr7:143745116 G/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.24 -0.31 9.58e-16 Obesity-related traits; BRCA cis rs6088590 0.710 rs6059992 chr20:33282275 T/C cg24642439 chr20:33292090 TP53INP2 0.54 11.86 0.42 1.87e-29 Coronary artery disease; BRCA cis rs7666738 0.830 rs13102652 chr4:99006737 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs11051970 0.636 rs10844198 chr12:32563479 G/T cg02745156 chr12:32552066 NA 0.25 8.4 0.32 2.93e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6446731 0.500 rs2858085 chr4:3271226 T/G cg08886695 chr4:3369023 RGS12 0.37 9.87 0.36 1.8e-21 Mean platelet volume; BRCA trans rs9929218 1.000 rs8056538 chr16:68802282 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -13.88 -0.48 1.69e-38 Colorectal cancer; BRCA cis rs4478858 0.735 rs4531329 chr1:31817810 A/T cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg18132916 chr6:79620363 NA -0.48 -10.88 -0.4 2.04e-25 Intelligence (multi-trait analysis); BRCA cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg11941060 chr3:133502564 NA 0.49 11.95 0.43 7.67e-30 Iron status biomarkers; BRCA cis rs9768139 0.733 rs12698209 chr7:158117595 A/G cg24154853 chr7:158122151 PTPRN2 -0.34 -8.04 -0.3 4.53e-15 Calcium levels; BRCA trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg15556689 chr8:8085844 FLJ10661 -0.39 -10.03 -0.37 4.33e-22 Triglycerides; BRCA cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA trans rs61931739 0.534 rs1608911 chr12:34010249 T/C cg26384229 chr12:38710491 ALG10B 0.67 13.91 0.48 1.34e-38 Morning vs. evening chronotype; BRCA cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.02 -0.37 4.67e-22 Alzheimer's disease (late onset); BRCA cis rs10883723 0.773 rs715439 chr10:104257809 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.8 0.62 2.22e-68 Allergic disease (asthma, hay fever or eczema); BRCA trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg11707556 chr5:10655725 ANKRD33B -0.48 -12.5 -0.44 3.15e-32 Height; BRCA cis rs7833790 0.724 rs6473309 chr8:82707880 A/G cg27398817 chr8:82754497 SNX16 -0.35 -7.97 -0.3 7.26e-15 Diastolic blood pressure; BRCA cis rs7592578 0.771 rs75579212 chr2:191376575 C/T cg10560079 chr2:191398806 TMEM194B -0.73 -13.47 -0.47 1.46e-36 Diastolic blood pressure; BRCA trans rs6582630 0.555 rs11182202 chr12:38476451 C/G cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs853679 0.517 rs4713137 chr6:28083521 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA cis rs17253792 0.822 rs75016910 chr14:56050466 C/G cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.29e-20 Putamen volume; BRCA cis rs6866344 0.697 rs11749438 chr5:178131245 C/T cg03877680 chr5:178157825 ZNF354A 0.8 14.85 0.51 4.43e-43 Neutrophil percentage of white cells; BRCA cis rs11229555 0.645 rs11229443 chr11:58197188 G/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9790314 1.000 rs9790314 chr3:161019558 T/C cg03342759 chr3:160939853 NMD3 -0.65 -14.94 -0.51 1.73e-43 Morning vs. evening chronotype; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg27588902 chr6:42928151 GNMT 0.3 10.05 0.37 3.53e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10927875 0.541 rs1739842 chr1:16342848 T/G cg06159980 chr1:16340746 HSPB7 -0.39 -8.85 -0.33 8.44e-18 Dilated cardiomyopathy; BRCA cis rs17767294 0.708 rs72848753 chr6:27878269 C/G cg08851530 chr6:28072375 NA 0.92 8.91 0.33 5.15e-18 Parkinson's disease; BRCA cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg23719950 chr11:63933701 MACROD1 -0.53 -8.54 -0.32 9.58e-17 Mean platelet volume; BRCA trans rs11098499 0.779 rs7699346 chr4:120310542 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.17 0.31 1.61e-15 Corneal astigmatism; BRCA cis rs12579753 1.000 rs17749267 chr12:82178308 A/G cg07988820 chr12:82153109 PPFIA2 0.57 9.21 0.34 4.77e-19 Resting heart rate; BRCA cis rs514406 0.708 rs514881 chr1:53336737 A/G cg01802117 chr1:53393560 SCP2 0.4 9.01 0.34 2.29e-18 Monocyte count; BRCA cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg14863265 chr7:2801509 GNA12 -0.42 -9.65 -0.36 1.2e-20 Height; BRCA cis rs11098499 0.954 rs10006706 chr4:120409152 A/G cg09307838 chr4:120376055 NA 0.72 15.31 0.52 2.78e-45 Corneal astigmatism; BRCA cis rs250677 0.652 rs250675 chr5:148438565 A/C cg23229984 chr5:148520753 ABLIM3 -0.35 -8.39 -0.32 3.02e-16 Breast cancer; BRCA trans rs3733585 0.673 rs6836706 chr4:9964251 T/A cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3772130 1.000 rs3772128 chr3:121345094 G/T cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.65 0.36 1.15e-20 Cognitive performance; BRCA cis rs7246967 0.611 rs2361022 chr19:22816533 A/G cg23217946 chr19:22817039 ZNF492 0.47 8.45 0.32 2e-16 Bronchopulmonary dysplasia; BRCA cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg12386194 chr3:101231763 SENP7 0.41 8.75 0.33 1.86e-17 Colorectal cancer; BRCA cis rs4242434 0.699 rs878051 chr8:22483836 T/C cg03733263 chr8:22462867 KIAA1967 0.79 18.19 0.58 6.41e-60 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA trans rs11165623 0.564 rs7555035 chr1:96996026 T/C cg10631902 chr5:14652156 NA -0.43 -12.17 -0.43 8.99e-31 Hip circumference;Waist circumference; BRCA cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.71 -0.33 2.66e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg03644281 chr6:41068752 NFYA;LOC221442 0.41 8.88 0.33 6.46e-18 Alzheimer's disease (late onset); BRCA cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg20701182 chr2:24300061 SF3B14 0.62 8.83 0.33 9.71e-18 Lymphocyte counts; BRCA cis rs7666738 0.830 rs1559859 chr4:99024325 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.59e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs4975616 0.714 rs37007 chr5:1352372 G/C cg06550200 chr5:1325588 CLPTM1L -0.6 -12.42 -0.44 7.1e-32 Lung cancer; BRCA cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg19274703 chr22:41806451 NA -0.36 -9.13 -0.34 8.88e-19 Vitiligo; BRCA cis rs2742234 0.541 rs10793424 chr10:43717116 G/T cg02780029 chr10:43622663 RET 0.35 7.86 0.3 1.69e-14 Hirschsprung disease; BRCA cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg13770153 chr20:60521292 NA 0.8 20.89 0.64 2.98e-74 Obesity-related traits; BRCA cis rs7917772 0.503 rs10748825 chr10:104293609 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs875971 0.830 rs778711 chr7:65851657 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs7927771 0.524 rs6485763 chr11:47627302 C/T cg20307385 chr11:47447363 PSMC3 0.45 10.38 0.38 1.91e-23 Subjective well-being; BRCA cis rs9814567 0.752 rs13075253 chr3:134329600 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.52 15.9 0.53 3.46e-48 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11608355 0.515 rs7955932 chr12:109941303 G/A cg05360138 chr12:110035743 NA 0.72 13.3 0.47 8.56e-36 Neuroticism; BRCA cis rs7267979 1.000 rs11087521 chr20:25440648 G/A cg08601574 chr20:25228251 PYGB 0.36 8.2 0.31 1.36e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg17366294 chr4:99064904 C4orf37 0.48 8.45 0.32 1.99e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg02733842 chr7:1102375 C7orf50 -0.65 -12.01 -0.43 4.31e-30 Bronchopulmonary dysplasia; BRCA cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA trans rs3733585 0.648 rs35954357 chr4:9978758 G/C cg26043149 chr18:55253948 FECH 0.36 7.9 0.3 1.2e-14 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg23533926 chr12:111358616 MYL2 -0.42 -8.73 -0.33 2.27e-17 Extrinsic epigenetic age acceleration; BRCA cis rs3771570 0.901 rs4675969 chr2:242217627 C/T cg21155796 chr2:242212141 HDLBP 0.48 8.32 0.31 5.48e-16 Prostate cancer; BRCA cis rs13040088 1.000 rs910831 chr20:61558775 T/C cg23096297 chr20:61557774 DIDO1 0.92 18.53 0.59 1.17e-61 Menopause (age at onset); BRCA cis rs4908768 0.501 rs12756257 chr1:8616933 C/A cg20416874 chr1:8611966 RERE -0.28 -8.17 -0.31 1.6e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7586879 0.616 rs6545809 chr2:25126715 C/T cg04586622 chr2:25135609 ADCY3 0.46 11.59 0.42 2.61e-28 Body mass index; BRCA cis rs4076764 0.914 rs6704467 chr1:163364512 A/G cg24596788 chr1:163392923 NA -0.39 -10.78 -0.39 5.09e-25 Motion sickness; BRCA cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -13.76 -0.48 6.54e-38 Cognitive function; BRCA trans rs62103177 0.713 rs62103186 chr18:77627574 G/C cg05926928 chr17:57297772 GDPD1 1.2 16.07 0.54 4.68e-49 Opioid sensitivity; BRCA trans rs853679 0.607 rs13216117 chr6:27938484 A/G cg06606381 chr12:133084897 FBRSL1 -0.89 -8.78 -0.33 1.44e-17 Depression; BRCA cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.57 0.35 2.25e-20 Lung cancer in ever smokers; BRCA cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg24060327 chr5:131705240 SLC22A5 0.62 11.61 0.42 2.12e-28 Breast cancer; BRCA cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.61 0.36 1.65e-20 Motion sickness; BRCA cis rs9469578 1.000 rs9469580 chr6:33715837 A/G cg18708504 chr6:33715942 IP6K3 -0.66 -9.94 -0.37 9.58e-22 Phosphorus levels; BRCA cis rs365132 0.875 rs3923879 chr5:176355312 C/T cg16309518 chr5:176445507 NA -0.39 -9.61 -0.36 1.59e-20 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs6977660 0.598 rs10239147 chr7:19787459 T/C cg07541023 chr7:19748670 TWISTNB 0.55 9.35 0.35 1.41e-19 Thyroid stimulating hormone; BRCA cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.66 13.75 0.48 6.93e-38 Lymphocyte counts; BRCA cis rs2010099 0.941 rs73191618 chr3:124301840 G/A cg14688451 chr3:124303035 KALRN 0.57 9.01 0.34 2.37e-18 Thyroid peroxidase antibody levels; BRCA cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.964 rs778735 chr7:65814809 C/A cg12463550 chr7:65579703 CRCP 0.37 8.04 0.3 4.35e-15 Aortic root size; BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.08 -0.34 1.29e-18 Total body bone mineral density; BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg08470875 chr2:26401718 FAM59B -0.52 -8.54 -0.32 1.02e-16 Gut microbiome composition (summer); BRCA cis rs4319547 0.656 rs4997380 chr12:122838956 A/G cg23029597 chr12:123009494 RSRC2 -0.43 -8.8 -0.33 1.29e-17 Body mass index; BRCA cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.77e-24 Motion sickness; BRCA trans rs931812 0.825 rs6993937 chr8:101898707 A/G cg20993868 chr7:22813445 NA 0.56 15.51 0.52 2.78e-46 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg07930192 chr7:1003750 NA 0.38 8.46 0.32 1.82e-16 Longevity;Endometriosis; BRCA trans rs4332037 0.538 rs6951956 chr7:1934131 C/T cg11693508 chr17:37793320 STARD3 0.37 8.11 0.31 2.6e-15 Bipolar disorder; BRCA cis rs600806 0.850 rs10858092 chr1:109943893 A/G cg20591472 chr1:110008990 SYPL2 -0.32 -7.86 -0.3 1.63e-14 Intelligence (multi-trait analysis); BRCA cis rs11051970 0.655 rs7298381 chr12:32530257 G/T cg24626660 chr12:32551988 NA 0.27 7.97 0.3 7.34e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs796364 0.806 rs203769 chr2:200900866 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.32 -0.38 3.36e-23 Schizophrenia; BRCA cis rs1832871 0.711 rs9459826 chr6:158680396 C/G cg07165851 chr6:158734300 TULP4 -0.62 -13.14 -0.46 4.29e-35 Height; BRCA cis rs698833 0.509 rs12987415 chr2:44530423 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.91 0.33 5.2e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg00024416 chr22:24240387 NA -0.32 -8.07 -0.3 3.62e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg24692254 chr21:30365293 RNF160 0.79 22.15 0.66 4.17e-81 Dental caries; BRCA trans rs6479891 0.818 rs11815969 chr10:65265855 C/T cg14819942 chr15:35414228 NA 0.35 8.59 0.32 6.62e-17 Arthritis (juvenile idiopathic); BRCA cis rs34779708 0.966 rs4934737 chr10:35512799 T/C cg03585969 chr10:35415529 CREM 0.49 9.96 0.37 8.03e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3917254 0.596 rs871658 chr2:102771865 G/C cg22835712 chr2:102737379 NA -0.51 -8.76 -0.33 1.81e-17 Blood protein levels; BRCA cis rs13631 0.697 rs1018330 chr9:139980385 A/C cg14289826 chr9:140003911 NA 0.35 8.46 0.32 1.81e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg06238570 chr21:40685208 BRWD1 -0.41 -8.37 -0.31 3.57e-16 Cognitive function; BRCA cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg08069147 chr6:88032118 GJB7;C6orf162 0.59 12.03 0.43 3.29e-30 Monocyte percentage of white cells; BRCA cis rs4930103 1.000 rs4930103 chr11:2024544 G/A cg06197492 chr11:2016605 H19 0.39 8.5 0.32 1.35e-16 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs12579753 0.872 rs12319937 chr12:82182545 T/G cg07988820 chr12:82153109 PPFIA2 -0.48 -8.46 -0.32 1.83e-16 Resting heart rate; BRCA cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.41 -0.54 9.05e-51 Alzheimer's disease (late onset); BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg12648201 chr2:27665141 KRTCAP3 -0.33 -8.01 -0.3 5.38e-15 Total body bone mineral density; BRCA cis rs6570726 0.905 rs396492 chr6:145816180 C/G cg23711669 chr6:146136114 FBXO30 0.63 14.31 0.49 1.72e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs936229 0.705 rs936227 chr15:75131959 A/G cg10253484 chr15:75165896 SCAMP2 -0.45 -9.06 -0.34 1.61e-18 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.26 -0.44 3.51e-31 Bipolar disorder; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.41 -0.32 2.64e-16 Total body bone mineral density; BRCA cis rs514406 0.929 rs554301 chr1:53321948 A/T cg25767906 chr1:53392781 SCP2 0.39 8.79 0.33 1.34e-17 Monocyte count; BRCA cis rs7582180 0.652 rs4851307 chr2:100971778 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.13e-14 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg15017067 chr4:17643749 FAM184B 0.29 8.47 0.32 1.74e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs28374715 0.662 rs691906 chr15:41474636 T/A cg18705301 chr15:41695430 NDUFAF1 0.78 16.64 0.55 6.31e-52 Ulcerative colitis; BRCA cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.01e-40 Motion sickness; BRCA cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.64 0.36 1.22e-20 Motion sickness; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19717773 chr7:2847554 GNA12 -0.42 -7.9 -0.3 1.21e-14 Height; BRCA cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg16586182 chr3:47516702 SCAP 0.55 12.36 0.44 1.3e-31 Colorectal cancer; BRCA trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg06636001 chr8:8085503 FLJ10661 -0.47 -8.98 -0.33 2.91e-18 Triglycerides; BRCA cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg06550200 chr5:1325588 CLPTM1L -0.64 -13.82 -0.48 3.31e-38 Lung cancer; BRCA trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg06636001 chr8:8085503 FLJ10661 -0.51 -10.93 -0.4 1.27e-25 Neuroticism; BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg19346786 chr7:2764209 NA -0.37 -10.83 -0.39 3.33e-25 Height; BRCA cis rs897080 0.552 rs1067375 chr2:44650118 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.44 -8.31 -0.31 5.83e-16 Height; BRCA cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg09184832 chr6:79620586 NA -0.52 -11.36 -0.41 2.21e-27 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.687 rs2320523 chr12:38251397 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.31 0.52 2.75e-45 Bladder cancer; BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.89 -0.3 1.31e-14 Total body bone mineral density; BRCA cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg17330251 chr7:94953956 PON1 -0.42 -8.71 -0.33 2.55e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1348850 0.914 rs7604673 chr2:178392346 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.7 0.36 7.44e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7264396 0.635 rs6060675 chr20:34493614 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.74 -0.5 1.48e-42 Total cholesterol levels; BRCA cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg08999081 chr20:33150536 PIGU -0.35 -8.92 -0.33 4.7e-18 Coronary artery disease; BRCA trans rs9858542 0.953 rs7646366 chr3:49470668 G/A cg21659725 chr3:3221576 CRBN -0.46 -9.97 -0.37 7.7e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs3008870 0.755 rs3736905 chr1:67392614 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.65 0.48 1.98e-37 Lymphocyte percentage of white cells; BRCA cis rs10484885 0.878 rs72921916 chr6:90555990 C/T cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.47 -0.35 5.11e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.38 -8.18 -0.31 1.55e-15 Osteoporosis; BRCA cis rs4919694 1.000 rs11191525 chr10:104793435 G/C cg04362960 chr10:104952993 NT5C2 0.94 14.51 0.5 1.96e-41 Arsenic metabolism; BRCA trans rs12517041 1.000 rs6894688 chr5:23312285 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.27 -0.31 7.52e-16 Calcium levels; BRCA cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg07636037 chr3:49044803 WDR6 0.98 29.45 0.76 4.46e-121 Parkinson's disease; BRCA cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg13319975 chr6:146136371 FBXO30 -0.43 -10.06 -0.37 3.38e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs17023223 0.537 rs12065809 chr1:119724535 A/T cg05756136 chr1:119680316 WARS2 -0.41 -7.98 -0.3 6.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA trans rs9951602 0.541 rs56882694 chr18:76647010 C/T cg02800362 chr5:177631904 HNRNPAB 0.76 17.65 0.57 4.21e-57 Obesity-related traits; BRCA cis rs4595586 0.545 rs12811619 chr12:39392196 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg17410650 chr12:54324560 NA -0.54 -15.46 -0.52 4.8e-46 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); BRCA cis rs6893300 0.785 rs55654737 chr5:179218842 G/A cg14593053 chr5:179126677 CANX -0.36 -7.88 -0.3 1.38e-14 Resting heart rate; BRCA cis rs4664304 0.620 rs10929956 chr2:160714615 C/T cg14819504 chr2:160761413 LY75 0.34 8.51 0.32 1.29e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs796364 0.616 rs769955 chr2:200692595 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.07 0.3 3.4e-15 Schizophrenia; BRCA cis rs7847628 0.587 rs12684934 chr9:123593159 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.95 26.26 0.72 1.19e-103 Birth weight; BRCA cis rs6840360 0.555 rs4554052 chr4:152726610 T/C cg22705602 chr4:152727874 NA 0.39 10.36 0.38 2.27e-23 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg12311346 chr5:56204834 C5orf35 -0.81 -16.16 -0.54 1.65e-49 Initial pursuit acceleration; BRCA cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg24829409 chr8:58192753 C8orf71 -0.5 -10.28 -0.38 5.02e-23 Developmental language disorder (linguistic errors); BRCA cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg27286337 chr10:134555280 INPP5A 0.61 10.21 0.37 8.7e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9457247 0.544 rs6920858 chr6:167464630 G/A cg07741184 chr6:167504864 NA 0.36 10.39 0.38 1.72e-23 Crohn's disease; BRCA cis rs9858542 0.953 rs1801143 chr3:49570200 C/T cg03060546 chr3:49711283 APEH -0.52 -10.92 -0.4 1.46e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg19628046 chr18:33552617 C18orf21 0.54 11.0 0.4 6.86e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg23711669 chr6:146136114 FBXO30 0.79 18.96 0.6 5.82e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg00071950 chr4:10020882 SLC2A9 0.55 12.94 0.46 3.68e-34 Bone mineral density; BRCA cis rs8016982 0.963 rs7149672 chr14:81657336 A/G cg01989461 chr14:81687754 GTF2A1 0.48 10.16 0.37 1.43e-22 Schizophrenia; BRCA cis rs2479724 0.901 rs6458244 chr6:41790455 C/T cg17623882 chr6:41773611 USP49 0.36 9.87 0.36 1.83e-21 Menarche (age at onset); BRCA trans rs9393777 0.841 rs34332556 chr6:27357414 C/G cg01620082 chr3:125678407 NA -0.69 -9.09 -0.34 1.21e-18 Intelligence (multi-trait analysis); BRCA cis rs8077889 0.672 rs2106764 chr17:41852717 T/A cg26893861 chr17:41843967 DUSP3 0.9 23.14 0.68 1.63e-86 Triglycerides; BRCA cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg09184832 chr6:79620586 NA -0.42 -8.45 -0.32 1.93e-16 Intelligence (multi-trait analysis); BRCA cis rs9649465 1.000 rs1468656 chr7:123375505 G/C cg04330084 chr7:123175371 IQUB -0.31 -8.64 -0.32 4.49e-17 Migraine; BRCA cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg12573674 chr2:1569213 NA -0.43 -7.87 -0.3 1.55e-14 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg03354898 chr7:1950403 MAD1L1 -0.38 -7.97 -0.3 7.23e-15 Bipolar disorder and schizophrenia; BRCA cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg21770322 chr7:97807741 LMTK2 0.44 11.74 0.42 6.15e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 16.0 0.53 9.87e-49 Platelet count; BRCA cis rs9318086 0.648 rs9510927 chr13:24467641 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.31 8.61 0.32 5.72e-17 Myopia (pathological); BRCA cis rs6484504 0.652 rs578666 chr11:31404484 C/T cg06552810 chr11:31128660 NA 0.37 8.2 0.31 1.36e-15 Red blood cell count; BRCA cis rs4363385 0.747 rs2225919 chr1:152969603 A/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.52 -0.32 1.18e-16 Inflammatory skin disease; BRCA trans rs9951602 0.512 rs56009939 chr18:76644497 T/G cg02800362 chr5:177631904 HNRNPAB 0.75 17.49 0.57 2.96e-56 Obesity-related traits; BRCA cis rs11809207 0.568 rs1892494 chr1:26497626 C/G cg00147160 chr1:26503991 CNKSR1 0.28 9.24 0.34 3.71e-19 Height; BRCA cis rs10046574 0.831 rs7810503 chr7:135142285 T/C cg27474649 chr7:135195673 CNOT4 0.61 8.71 0.33 2.65e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7949030 0.591 rs35156678 chr11:62369881 G/A cg11742103 chr11:62369870 EML3;MTA2 0.54 13.37 0.47 3.92e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs1568889 1.000 rs7112860 chr11:28151609 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 14.94 0.51 1.63e-43 Bipolar disorder; BRCA trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg15556689 chr8:8085844 FLJ10661 0.39 9.56 0.35 2.51e-20 Retinal vascular caliber; BRCA cis rs1997103 1.000 rs2877284 chr7:55408778 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.84 0.36 2.34e-21 Bipolar disorder; BRCA cis rs2070488 0.965 rs4679060 chr3:38536261 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.73 -20.07 -0.62 7.18e-70 Electrocardiographic conduction measures; BRCA cis rs11583043 0.793 rs3903905 chr1:101420957 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.66 0.36 1.07e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.67 0.39 1.48e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg16339924 chr4:17578868 LAP3 0.56 13.89 0.48 1.62e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs922182 0.633 rs12592702 chr15:64271882 C/T cg24729988 chr15:64271149 DAPK2 -0.65 -16.7 -0.55 3.04e-52 Blood protein levels; BRCA cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.53 -0.35 3.34e-20 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg08470875 chr2:26401718 FAM59B -0.72 -10.35 -0.38 2.56e-23 Gut microbiome composition (summer); BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg23708337 chr7:1209742 NA 0.58 12.58 0.45 1.34e-32 Longevity;Endometriosis; BRCA cis rs858239 0.601 rs929508 chr7:23166709 C/A cg23682824 chr7:23144976 KLHL7 0.45 11.94 0.43 8.21e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs7590368 0.924 rs72779464 chr2:10963159 T/C cg15705551 chr2:10952987 PDIA6 0.43 8.06 0.3 3.89e-15 Educational attainment (years of education); BRCA cis rs858239 0.600 rs7776649 chr7:23119317 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.95 0.43 7.85e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs858239 0.831 rs7796541 chr7:23389073 G/T cg23682824 chr7:23144976 KLHL7 0.32 8.13 0.31 2.29e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg00290607 chr11:67383545 NA 0.52 11.5 0.41 5.78e-28 Mean corpuscular volume; BRCA trans rs6582630 0.574 rs12146797 chr12:38436499 T/C cg06521331 chr12:34319734 NA -0.46 -8.53 -0.32 1.08e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11890956 chr21:40555474 PSMG1 -0.84 -21.45 -0.65 2.87e-77 Cognitive function; BRCA cis rs9287719 0.649 rs2024433 chr2:10731504 G/C cg00105475 chr2:10696890 NA 0.41 9.07 0.34 1.44e-18 Prostate cancer; BRCA cis rs7927771 1.000 rs34128973 chr11:47851376 C/T cg18512352 chr11:47633146 NA -0.35 -8.38 -0.31 3.41e-16 Subjective well-being; BRCA cis rs611744 0.647 rs2859813 chr8:109263497 G/A cg21045802 chr8:109455806 TTC35 0.34 7.87 0.3 1.52e-14 Dupuytren's disease; BRCA cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9611565 0.694 rs202628 chr22:41849513 A/G cg19274703 chr22:41806451 NA 0.35 9.09 0.34 1.19e-18 Vitiligo; BRCA cis rs2249625 0.564 rs2496489 chr6:72877338 G/A cg18830697 chr6:72922368 RIMS1 -0.64 -14.59 -0.5 8.31e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs3106136 0.546 rs2276910 chr4:95129238 T/C cg11021082 chr4:95130006 SMARCAD1 -0.41 -8.49 -0.32 1.4e-16 Capecitabine sensitivity; BRCA trans rs35110281 0.667 rs2070533 chr21:45122753 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.85 0.33 8.55e-18 Mean corpuscular volume; BRCA trans rs629535 0.783 rs538832 chr8:70033817 A/G cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs6088580 0.524 rs2378251 chr20:33276750 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -8.47 -0.32 1.67e-16 Glomerular filtration rate (creatinine); BRCA cis rs1568889 0.938 rs1464898 chr11:28034748 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.58 0.5 8.73e-42 Bipolar disorder; BRCA cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 12.84 0.45 9.76e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7249142 0.549 rs2238667 chr19:19282523 G/A cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.27 -0.31 8.03e-16 IgG glycosylation; BRCA trans rs3733585 0.775 rs13124007 chr4:10043931 G/C cg26043149 chr18:55253948 FECH 0.4 8.71 0.33 2.66e-17 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -10.75 -0.39 6.6e-25 Alzheimer's disease; BRCA cis rs6430585 0.527 rs2254780 chr2:136435526 C/T cg07169764 chr2:136633963 MCM6 0.9 17.31 0.56 2.5e-55 Corneal structure; BRCA cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg21132104 chr15:45694354 SPATA5L1 -0.73 -16.48 -0.55 3.9e-51 Homoarginine levels; BRCA cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.92 0.4 1.41e-25 Bipolar disorder; BRCA cis rs798554 0.704 rs798513 chr7:2782493 C/T cg09658497 chr7:2847517 GNA12 -0.41 -8.47 -0.32 1.75e-16 Height; BRCA cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg12756686 chr19:29218302 NA 0.51 8.83 0.33 1.04e-17 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs2742234 1.000 rs2742234 chr10:43612609 A/G cg15436174 chr10:43711423 RASGEF1A 0.44 9.73 0.36 5.83e-21 Hirschsprung disease; BRCA cis rs782590 0.967 rs35504023 chr2:55806503 C/T cg18811423 chr2:55921094 PNPT1 -0.71 -23.32 -0.68 1.67e-87 Metabolic syndrome; BRCA cis rs117623576 0.941 rs211409 chr10:32393213 T/C cg03047570 chr10:32398778 NA 0.65 9.79 0.36 3.53e-21 Anti-saccade response; BRCA cis rs6840360 0.615 rs4696094 chr4:152465501 C/T cg22705602 chr4:152727874 NA -0.35 -8.52 -0.32 1.19e-16 Intelligence (multi-trait analysis); BRCA cis rs713587 0.646 rs34697209 chr2:25127394 A/G cg04586622 chr2:25135609 ADCY3 0.47 11.8 0.42 3.31e-29 Body mass index in non-asthmatics; BRCA cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg06784218 chr1:46089804 CCDC17 -0.44 -10.42 -0.38 1.32e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg26408565 chr15:76604113 ETFA -0.39 -8.65 -0.32 4.17e-17 Blood metabolite levels; BRCA trans rs7615952 0.512 rs2922175 chr3:125361360 T/C cg07211511 chr3:129823064 LOC729375 -0.58 -10.64 -0.39 1.84e-24 Blood pressure (smoking interaction); BRCA cis rs6878727 0.549 rs920997 chr5:123648021 A/G cg01806427 chr5:123737813 NA -0.4 -8.86 -0.33 7.6e-18 Breast cancer; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg09177884 chr7:1199841 ZFAND2A -0.47 -10.25 -0.38 6.41e-23 Longevity;Endometriosis; BRCA cis rs2066819 0.786 rs111580405 chr12:56739557 A/G cg26734620 chr12:56694298 CS 0.88 9.96 0.37 8.09e-22 Psoriasis vulgaris; BRCA trans rs7615952 0.641 rs4422257 chr3:125774363 A/G cg07211511 chr3:129823064 LOC729375 -0.63 -11.04 -0.4 4.71e-26 Blood pressure (smoking interaction); BRCA trans rs66887589 0.616 rs11731675 chr4:120212514 T/C cg25214090 chr10:38739885 LOC399744 0.37 8.6 0.32 6.27e-17 Diastolic blood pressure; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.56 11.59 0.42 2.54e-28 Lymphocyte counts; BRCA cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.45 -9.26 -0.34 3.03e-19 Tonsillectomy; BRCA trans rs6951245 0.872 rs76161580 chr7:1100307 G/T cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg10523679 chr1:76189770 ACADM 0.71 12.12 0.43 1.35e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg13047869 chr3:10149882 C3orf24 0.6 12.53 0.44 2.23e-32 Alzheimer's disease; BRCA cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg04727924 chr7:799746 HEATR2 -0.52 -10.49 -0.38 7.54e-24 Cerebrospinal P-tau181p levels; BRCA cis rs40363 0.723 rs757269 chr16:3538003 A/G cg21433313 chr16:3507492 NAT15 -0.55 -8.16 -0.31 1.78e-15 Tuberculosis; BRCA cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg10057126 chr4:77819792 ANKRD56 0.64 14.82 0.51 6.13e-43 Emphysema distribution in smoking; BRCA cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg23719950 chr11:63933701 MACROD1 -0.53 -8.49 -0.32 1.4e-16 Mean platelet volume; BRCA cis rs6543140 0.964 rs6736135 chr2:103064924 A/G cg04239558 chr2:103089729 SLC9A4 0.34 9.42 0.35 8.32e-20 Blood protein levels; BRCA cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg01802117 chr1:53393560 SCP2 0.41 8.57 0.32 7.72e-17 Monocyte count; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg23978390 chr7:1156363 C7orf50 0.41 9.36 0.35 1.28e-19 Longevity;Endometriosis; BRCA cis rs11758351 0.660 rs11753655 chr6:26220109 C/T cg01420254 chr6:26195488 NA 0.56 8.74 0.33 2.03e-17 Gout;Renal underexcretion gout; BRCA cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs11711311 1.000 rs9855613 chr3:113448455 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.53 0.32 1.03e-16 IgG glycosylation; BRCA cis rs10193935 0.901 rs2286702 chr2:42555473 C/T cg27598129 chr2:42591480 NA -0.97 -14.96 -0.51 1.34e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs654950 0.934 rs665223 chr1:42000654 A/T cg06885757 chr1:42089581 HIVEP3 -0.28 -9.78 -0.36 3.89e-21 Airway imaging phenotypes; BRCA cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg20701182 chr2:24300061 SF3B14 0.58 9.1 0.34 1.12e-18 Lymphocyte counts; BRCA cis rs4808199 0.649 rs34755166 chr19:19665581 G/A cg03709012 chr19:19516395 GATAD2A 0.75 11.93 0.43 8.93e-30 Nonalcoholic fatty liver disease; BRCA cis rs4481887 0.927 rs10788779 chr1:248481661 C/G cg00666640 chr1:248458726 OR2T12 0.29 8.26 0.31 8.47e-16 Common traits (Other); BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg25482853 chr8:67687455 SGK3 1.05 16.94 0.56 1.94e-53 Lung disease severity in cystic fibrosis; BRCA cis rs11098499 0.863 rs10004484 chr4:120442428 C/T cg09307838 chr4:120376055 NA 0.69 14.86 0.51 3.94e-43 Corneal astigmatism; BRCA trans rs75804782 0.581 rs3191996 chr2:239344412 A/G cg01134436 chr17:81009848 B3GNTL1 -0.77 -9.93 -0.37 1.04e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs801193 0.660 rs4610622 chr7:66224497 T/C cg11764359 chr7:65958608 NA 0.78 18.57 0.59 7.06e-62 Aortic root size; BRCA trans rs7786808 0.615 rs4909209 chr7:158194329 C/T cg02030672 chr11:45687055 CHST1 0.51 11.5 0.41 6.23e-28 Obesity-related traits; BRCA cis rs7666738 0.830 rs13125930 chr4:98654695 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.59 0.5 7.73e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs208520 1.000 rs9453671 chr6:66991208 A/G cg07460842 chr6:66804631 NA 0.73 12.19 0.43 7.02e-31 Exhaled nitric oxide output; BRCA cis rs7729447 0.813 rs7715779 chr5:32690199 T/G cg16267343 chr5:32710456 NPR3 0.44 9.09 0.34 1.2e-18 Blood pressure; BRCA cis rs2191566 0.576 rs420584 chr19:44495257 C/T cg20607764 chr19:44506953 ZNF230 0.37 8.03 0.3 4.64e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs40363 0.645 rs4786421 chr16:3522303 A/G cg21433313 chr16:3507492 NAT15 -0.46 -10.23 -0.38 7.31e-23 Tuberculosis; BRCA cis rs7917772 0.636 rs2486757 chr10:104535145 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 10.53 0.38 5.1900000000000004e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg17971929 chr21:40555470 PSMG1 -0.49 -10.84 -0.39 3.13e-25 Menarche (age at onset); BRCA cis rs7617773 0.817 rs11130163 chr3:48312658 T/C cg11946769 chr3:48343235 NME6 0.52 11.71 0.42 7.56e-29 Coronary artery disease; BRCA trans rs12517041 1.000 rs2081951 chr5:23287576 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs4930561 0.714 rs7945995 chr11:67938302 A/G cg04465784 chr11:67976953 SUV420H1 -0.26 -8.59 -0.32 6.51e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs7312933 1.000 rs11181328 chr12:42504679 T/G cg01256987 chr12:42539512 GXYLT1 -0.57 -11.6 -0.42 2.3e-28 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg20587970 chr11:113659929 NA -1.37 -24.64 -0.7 9.94e-95 Hip circumference adjusted for BMI; BRCA cis rs17092148 1.000 rs7265992 chr20:33525407 G/A cg16810054 chr20:33298113 TP53INP2 0.48 10.47 0.38 8.67e-24 Neuroticism; BRCA cis rs1577917 0.917 rs1414201 chr6:86500316 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.43 -0.44 6.22e-32 Response to antipsychotic treatment; BRCA cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg03161606 chr19:29218774 NA 0.47 8.0 0.3 5.92e-15 Methadone dose in opioid dependence; BRCA cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg06115741 chr20:33292138 TP53INP2 0.5 11.22 0.41 8.59e-27 Coronary artery disease; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg08470875 chr2:26401718 FAM59B 0.76 11.92 0.43 1.02e-29 Gut microbiome composition (summer); BRCA trans rs11098499 0.663 rs9996501 chr4:120238918 C/A cg25214090 chr10:38739885 LOC399744 0.46 10.61 0.39 2.52e-24 Corneal astigmatism; BRCA cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg08999081 chr20:33150536 PIGU 0.46 12.93 0.46 3.95e-34 Glomerular filtration rate (creatinine); BRCA cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg10523679 chr1:76189770 ACADM -0.77 -18.43 -0.59 4.01e-61 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg18850127 chr7:39170497 POU6F2 0.48 10.72 0.39 9.06e-25 IgG glycosylation; BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg06468780 chr21:31798236 KRTAP13-3 0.35 8.74 0.33 2.02e-17 HDL cholesterol; BRCA cis rs2882667 0.690 rs288011 chr5:138199939 C/T cg04439458 chr5:138467593 SIL1 0.31 7.94 0.3 8.86e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11644478 chr21:40555479 PSMG1 -0.5 -10.46 -0.38 1e-23 Menarche (age at onset); BRCA cis rs2637030 0.559 rs256108 chr5:52874253 C/T cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg08564027 chr20:61660810 NA 0.84 22.77 0.67 1.63e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs6942756 1.000 rs6467233 chr7:128868656 C/T cg02491457 chr7:128862824 NA -0.71 -14.29 -0.49 2.22e-40 White matter hyperintensity burden; BRCA cis rs7520050 0.966 rs10749860 chr1:46328210 C/G cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg06618935 chr21:46677482 NA -0.37 -8.14 -0.31 2e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg26384229 chr12:38710491 ALG10B -0.57 -14.13 -0.49 1.23e-39 Morning vs. evening chronotype; BRCA cis rs1348850 0.567 rs3770009 chr2:178536544 C/T cg22681709 chr2:178499509 PDE11A -0.38 -8.4 -0.32 2.92e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg21475434 chr5:93447410 FAM172A 0.71 9.09 0.34 1.27e-18 Diabetic retinopathy; BRCA cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg26597838 chr10:835615 NA 1.31 21.51 0.65 1.36e-77 Eosinophil percentage of granulocytes; BRCA cis rs3857536 0.740 rs7745163 chr6:66889936 A/G cg07460842 chr6:66804631 NA -0.47 -9.09 -0.34 1.25e-18 Blood trace element (Cu levels); BRCA cis rs12541635 0.966 rs7839239 chr8:107020406 C/T cg10147462 chr8:107024639 NA 0.36 9.88 0.36 1.63e-21 Age of smoking initiation; BRCA trans rs9858542 1.000 rs11709525 chr3:49690496 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.67 -0.36 9.71e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg14530993 chr4:882597 GAK 0.58 9.27 0.34 2.84e-19 Intelligence (multi-trait analysis); BRCA cis rs61990749 0.597 rs11624101 chr14:78138059 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.63 -9.58 -0.35 2.19e-20 Fibroblast growth factor basic levels; BRCA cis rs10189230 1.000 rs10189230 chr2:222357961 T/A cg14652038 chr2:222343519 EPHA4 0.48 13.32 0.47 6.72e-36 Urate levels in lean individuals; BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.88 -0.36 1.55e-21 Alzheimer's disease (late onset); BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg12419862 chr22:24373484 LOC391322 0.92 24.22 0.69 2.05e-92 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs6089829 0.925 rs4809270 chr20:61676709 C/A cg23505145 chr19:12996616 KLF1 0.54 11.84 0.42 2.18e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.54 11.15 0.4 1.63e-26 Multiple sclerosis; BRCA cis rs2288073 0.965 rs10469924 chr2:24416230 G/A cg26838691 chr2:24397539 C2orf84 -0.48 -8.75 -0.33 1.92e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs2637266 1.000 rs10219107 chr10:78364369 T/C cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs9311474 0.713 rs352166 chr3:52238677 C/T cg15698299 chr3:52233019 ALAS1 -0.39 -9.13 -0.34 8.86e-19 Electroencephalogram traits; BRCA cis rs6565180 1.000 rs11862806 chr16:30364071 A/G cg17640201 chr16:30407289 ZNF48 -0.78 -19.88 -0.62 7.99e-69 Tonsillectomy; BRCA cis rs12579753 1.000 rs10862368 chr12:82244514 C/T cg07988820 chr12:82153109 PPFIA2 -0.65 -10.48 -0.38 7.7e-24 Resting heart rate; BRCA trans rs629535 0.821 rs650267 chr8:70029160 C/T cg21567404 chr3:27674614 NA 1.0 20.96 0.64 1.17e-74 Dupuytren's disease; BRCA cis rs11098499 0.820 rs28394116 chr4:120524283 T/G cg09307838 chr4:120376055 NA 0.68 13.66 0.48 1.79e-37 Corneal astigmatism; BRCA trans rs8062405 0.964 rs72793809 chr16:28832382 C/T cg09719594 chr16:21412588 NA -0.32 -7.82 -0.3 2.19e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg11366901 chr6:160182831 ACAT2 0.78 14.82 0.51 6.21e-43 Age-related macular degeneration (geographic atrophy); BRCA trans rs1005277 0.683 rs7923868 chr10:37989766 T/C cg17830980 chr10:43048298 ZNF37B -0.35 -7.97 -0.3 7.06e-15 Extrinsic epigenetic age acceleration; BRCA cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.33 -8.12 -0.31 2.37e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7737355 0.947 rs11242078 chr5:130792035 A/C cg06307176 chr5:131281290 NA -0.53 -10.6 -0.39 2.62e-24 Life satisfaction; BRCA cis rs6700896 0.931 rs17127849 chr1:66105512 A/G cg04111102 chr1:66153794 NA 0.34 8.27 0.31 7.98e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg24308560 chr3:49941425 MST1R -0.4 -8.53 -0.32 1.09e-16 Intelligence (multi-trait analysis); BRCA cis rs9858542 0.953 rs67216675 chr3:49493151 G/T cg03060546 chr3:49711283 APEH -0.53 -10.58 -0.39 3.33e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs875971 0.660 rs801211 chr7:66015689 T/G cg11764359 chr7:65958608 NA -0.68 -15.19 -0.52 9.74e-45 Aortic root size; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg03354898 chr7:1950403 MAD1L1 0.52 10.96 0.4 9.93e-26 Bipolar disorder and schizophrenia; BRCA cis rs752010 0.746 rs11210499 chr1:42089703 C/T cg06885757 chr1:42089581 HIVEP3 -0.31 -11.37 -0.41 2.08e-27 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6547741 1.000 rs76784350 chr2:27764278 A/G cg27432699 chr2:27873401 GPN1 0.46 9.73 0.36 6.08e-21 Oral cavity cancer; BRCA cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg22508957 chr16:3507546 NAT15 0.42 9.5 0.35 4.28e-20 Tuberculosis; BRCA cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg26818010 chr10:134567672 INPP5A -0.64 -13.42 -0.47 2.38e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10876993 0.893 rs1678504 chr12:58085498 G/C cg18357645 chr12:58087776 OS9 0.49 14.05 0.49 2.8e-39 Celiac disease or Rheumatoid arthritis; BRCA trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.19 -19.18 -0.6 4.17e-65 Hemostatic factors and hematological phenotypes; BRCA cis rs870825 0.616 rs57086463 chr4:185639525 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -11.08 -0.4 3.25e-26 Neuroticism; BRCA cis rs4728302 0.869 rs12707129 chr7:133593177 A/G cg07491979 chr7:133331646 EXOC4 0.36 7.89 0.3 1.31e-14 Intelligence;Intelligence (multi-trait analysis); BRCA trans rs61931739 0.517 rs7975714 chr12:34055611 T/C cg26384229 chr12:38710491 ALG10B 0.68 14.37 0.49 9.31e-41 Morning vs. evening chronotype; BRCA cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg24596788 chr1:163392923 NA -0.39 -10.55 -0.39 4.4e-24 Motion sickness; BRCA cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg08885076 chr2:99613938 TSGA10 -0.44 -8.68 -0.32 3.35e-17 Chronic sinus infection; BRCA cis rs2839186 0.681 rs13047198 chr21:47701835 T/C cg12379764 chr21:47803548 PCNT -0.41 -8.48 -0.32 1.51e-16 Testicular germ cell tumor; BRCA cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg23029597 chr12:123009494 RSRC2 0.58 11.45 0.41 9.89e-28 Body mass index; BRCA cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg06618935 chr21:46677482 NA -0.38 -8.56 -0.32 8.2e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs28830936 1.000 rs9672298 chr15:41912368 A/C cg17847044 chr15:42102381 MAPKBP1 -0.32 -9.23 -0.34 3.76e-19 Diastolic blood pressure; BRCA cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.23e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg04990556 chr1:26633338 UBXN11 -0.47 -9.21 -0.34 4.72e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 4e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.78 0.42 4.15e-29 Tonsillectomy; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg08805041 chr16:621841 PIGQ -0.31 -8.58 -0.32 7.02e-17 Height; BRCA cis rs17095355 1.000 rs17126877 chr10:111672786 C/T cg00817464 chr10:111662876 XPNPEP1 -0.42 -8.95 -0.33 3.83e-18 Biliary atresia; BRCA cis rs453301 0.606 rs6981060 chr8:8908235 C/A cg15556689 chr8:8085844 FLJ10661 -0.35 -9.11 -0.34 1.01e-18 Joint mobility (Beighton score); BRCA cis rs7246657 0.943 rs3803895 chr19:37898669 A/G cg14683738 chr19:37701593 ZNF585B 0.44 7.84 0.3 1.91e-14 Coronary artery calcification; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 17.01 0.56 8.75e-54 Alzheimer's disease; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg03609598 chr5:56110824 MAP3K1 -0.49 -8.22 -0.31 1.16e-15 Initial pursuit acceleration; BRCA cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg00071950 chr4:10020882 SLC2A9 0.58 14.11 0.49 1.55e-39 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs919433 0.519 rs700658 chr2:198655007 A/T cg00792783 chr2:198669748 PLCL1 0.47 10.33 0.38 3.09e-23 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs67311347 1.000 rs9332450 chr3:40458041 C/T cg09455208 chr3:40491958 NA -0.39 -9.34 -0.35 1.5700000000000001e-19 Renal cell carcinoma; BRCA cis rs2624839 0.602 rs2526398 chr3:50187596 G/C cg14019146 chr3:50243930 SLC38A3 -0.64 -15.93 -0.53 2.41e-48 Intelligence (multi-trait analysis); BRCA cis rs2860975 0.905 rs10786182 chr10:96789775 C/T cg09036531 chr10:96991505 NA -0.39 -8.34 -0.31 4.65e-16 Immune response to smallpox vaccine (IL-6); BRCA cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.42 0.63 1.05e-71 Smoking behavior; BRCA cis rs35306767 0.855 rs11253459 chr10:886402 C/T cg26597838 chr10:835615 NA 0.91 16.27 0.54 4.77e-50 Eosinophil percentage of granulocytes; BRCA cis rs1580019 0.885 rs4580942 chr7:32496435 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.73 15.65 0.53 5.5e-47 Cognitive ability; BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.64 0.39 1.95e-24 Tonsillectomy; BRCA cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg12573674 chr2:1569213 NA -0.51 -9.63 -0.36 1.34e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs13256369 0.851 rs13254997 chr8:8563753 G/C cg00074818 chr8:8560427 CLDN23 0.38 8.3 0.31 6.14e-16 Obesity-related traits; BRCA cis rs1577917 0.538 rs6454483 chr6:86418283 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.33 9.03 0.34 1.99e-18 Response to antipsychotic treatment; BRCA trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg15704280 chr7:45808275 SEPT13 0.6 10.69 0.39 1.21e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg11189052 chr15:85197271 WDR73 0.42 8.71 0.33 2.55e-17 Schizophrenia; BRCA cis rs3781663 0.500 rs7931752 chr11:70022846 T/C cg06393558 chr11:69982916 ANO1 -0.39 -8.96 -0.33 3.55e-18 Survival in rectal cancer; BRCA trans rs3780486 0.801 rs3780495 chr9:33125942 A/C cg20290983 chr6:43655470 MRPS18A 1.12 41.57 0.85 6.92e-184 IgG glycosylation; BRCA cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg08807101 chr21:30365312 RNF160 -0.39 -8.37 -0.31 3.69e-16 Pancreatic cancer; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg08470875 chr2:26401718 FAM59B -0.52 -8.54 -0.32 1.02e-16 Gut microbiome composition (summer); BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.94 0.33 4.3e-18 Tonsillectomy; BRCA cis rs1577917 1.000 rs34281561 chr6:86701872 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.19 -0.46 2.51e-35 Response to antipsychotic treatment; BRCA cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg14926445 chr8:58193284 C8orf71 -0.47 -9.0 -0.34 2.48e-18 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg13047869 chr3:10149882 C3orf24 0.58 12.26 0.44 3.53e-31 Alzheimer's disease; BRCA cis rs796364 1.000 rs166845 chr2:200823360 T/A cg23649088 chr2:200775458 C2orf69 0.56 8.11 0.31 2.5e-15 Schizophrenia; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg08470875 chr2:26401718 FAM59B -0.72 -11.89 -0.43 1.31e-29 Gut microbiome composition (summer); BRCA cis rs3806843 1.000 rs10223116 chr5:140192643 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.26 -0.34 3.06e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs7092929 0.680 rs24401 chr10:3584829 A/G cg14308648 chr10:3568949 NA -0.42 -8.18 -0.31 1.5e-15 Coronary artery calcification; BRCA cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11890956 chr21:40555474 PSMG1 -0.65 -14.71 -0.5 2.13e-42 Menarche (age at onset); BRCA cis rs870825 0.860 rs55974219 chr4:185600733 G/A cg04058563 chr4:185651563 MLF1IP 0.82 13.82 0.48 3.56e-38 Blood protein levels; BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg12444411 chr7:2802554 GNA12 -0.35 -8.6 -0.32 6.13e-17 Height; BRCA cis rs2011503 0.941 rs2074302 chr19:19381728 G/C cg11584989 chr19:19387371 SF4 0.6 13.8 0.48 3.99e-38 Bipolar disorder; BRCA cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg13010199 chr12:38710504 ALG10B 0.55 12.01 0.43 4.36e-30 Heart rate; BRCA trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA cis rs2635047 1.000 rs9304341 chr18:44670263 G/A cg19077165 chr18:44547161 KATNAL2 -0.39 -8.41 -0.32 2.65e-16 Educational attainment; BRCA cis rs7147624 0.882 rs1956008 chr14:66085429 G/T cg03016385 chr14:66212404 NA -0.59 -9.06 -0.34 1.57e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs9296092 0.538 rs62405942 chr6:33517346 G/A cg13560919 chr6:33536144 NA -0.85 -18.39 -0.59 6.37e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs3857067 0.806 rs11943926 chr4:95136512 G/A cg11021082 chr4:95130006 SMARCAD1 -0.41 -9.72 -0.36 6.56e-21 QT interval; BRCA cis rs72634258 0.554 rs34305100 chr1:7913029 A/G cg00042356 chr1:8021962 PARK7 0.55 8.35 0.31 4.25e-16 Inflammatory bowel disease; BRCA cis rs4660306 1.000 rs1044717 chr1:45976587 A/G cg24296786 chr1:45957014 TESK2 0.43 8.56 0.32 8.52e-17 Homocysteine levels; BRCA cis rs250677 0.687 rs2963485 chr5:148452043 A/G cg18129178 chr5:148520854 ABLIM3 0.46 9.08 0.34 1.38e-18 Breast cancer; BRCA cis rs514406 0.505 rs856721 chr1:53162156 C/A cg08859206 chr1:53392774 SCP2 -0.41 -8.24 -0.31 9.49e-16 Monocyte count; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg10862848 chr6:42927986 GNMT -0.35 -14.69 -0.5 2.78e-42 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11984145 1.000 rs60354841 chr7:38873461 T/C cg19327137 chr7:38886074 VPS41 0.5 7.91 0.3 1.15e-14 Cognitive performance; BRCA cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.14e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs7939886 0.920 rs74699881 chr11:55913852 A/T cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs4690686 0.534 rs11133147 chr4:177281718 A/G cg17059388 chr4:177262070 NA 0.36 8.23 0.31 1.06e-15 Essential tremor; BRCA cis rs12760731 0.565 rs35038893 chr1:178168417 C/T cg00404053 chr1:178313656 RASAL2 0.64 7.82 0.3 2.11e-14 Obesity-related traits; BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg13047869 chr3:10149882 C3orf24 0.53 11.24 0.41 6.83e-27 Alzheimer's disease; BRCA trans rs1325195 0.879 rs2793798 chr1:179094843 G/A cg11624085 chr17:8464688 MYH10 -0.26 -7.84 -0.3 1.9e-14 IgE grass sensitization; BRCA cis rs7917772 0.582 rs10786685 chr10:104323103 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.49 14.29 0.49 2.03e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg21770322 chr7:97807741 LMTK2 0.45 11.71 0.42 7.96e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs1595825 0.891 rs73056840 chr2:198783466 C/A cg19156104 chr2:198669113 PLCL1 -0.41 -7.84 -0.3 1.89e-14 Ulcerative colitis; BRCA cis rs4919087 1.000 rs10786333 chr10:99090390 A/G cg25902810 chr10:99078978 FRAT1 -0.45 -9.49 -0.35 4.54e-20 Monocyte count; BRCA trans rs1459104 1.000 rs35726021 chr11:55191206 G/A cg15704280 chr7:45808275 SEPT13 0.66 8.14 0.31 2.03e-15 Body mass index; BRCA cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.28 0.47 1.01e-35 High light scatter reticulocyte count; BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.85 0.48 2.55e-38 Alzheimer's disease; BRCA cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg12386194 chr3:101231763 SENP7 -0.62 -12.1 -0.43 1.67e-30 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 20.16 0.62 2.4e-70 Platelet count; BRCA cis rs367615 0.731 rs58241713 chr5:108853664 G/A cg17395555 chr5:108820864 NA 0.37 11.39 0.41 1.78e-27 Colorectal cancer (SNP x SNP interaction); BRCA cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -18.01 -0.58 6.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg14019146 chr3:50243930 SLC38A3 -0.57 -11.7 -0.42 8.46e-29 Intelligence (multi-trait analysis); BRCA trans rs6952808 0.601 rs3778978 chr7:2159817 A/G cg04565464 chr8:145669602 NFKBIL2 0.42 9.49 0.35 4.57e-20 Bipolar disorder and schizophrenia; BRCA trans rs1997103 0.871 rs6956733 chr7:55393032 A/C cg20935933 chr6:143382018 AIG1 0.58 10.26 0.38 5.88e-23 QRS interval (sulfonylurea treatment interaction); BRCA trans rs629535 0.773 rs568159 chr8:70032908 C/G cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs4363385 0.782 rs4845336 chr1:153003853 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.83e-16 Inflammatory skin disease; BRCA cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg16414030 chr3:133502952 NA 0.46 10.82 0.39 3.66e-25 Iron status biomarkers; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.59 -11.29 -0.41 4.5e-27 Gut microbiome composition (summer); BRCA cis rs752010 0.967 rs2038978 chr1:42094719 A/G cg06885757 chr1:42089581 HIVEP3 0.24 8.67 0.32 3.61e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs4481887 0.927 rs4390208 chr1:248472211 C/T cg00666640 chr1:248458726 OR2T12 0.29 8.23 0.31 1.08e-15 Common traits (Other); BRCA cis rs7618501 0.521 rs55692411 chr3:49911155 G/A cg24110177 chr3:50126178 RBM5 -0.52 -15.46 -0.52 4.74e-46 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg22535103 chr8:58192502 C8orf71 -0.61 -13.25 -0.46 1.34e-35 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg08470875 chr2:26401718 FAM59B 0.74 12.04 0.43 2.96e-30 Gut microbiome composition (summer); BRCA cis rs10089 1.000 rs10463838 chr5:127518305 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.57 12.99 0.46 2.07e-34 Ileal carcinoids; BRCA cis rs4481887 0.927 rs7521689 chr1:248435831 G/T cg00666640 chr1:248458726 OR2T12 0.33 8.48 0.32 1.51e-16 Common traits (Other); BRCA cis rs2832191 0.791 rs4817270 chr21:30480368 G/A cg24692254 chr21:30365293 RNF160 -0.66 -17.95 -0.58 1.26e-58 Dental caries; BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26314531 chr2:26401878 FAM59B 0.9 15.14 0.51 1.7e-44 Gut microbiome composition (summer); BRCA cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11890956 chr21:40555474 PSMG1 -0.83 -21.45 -0.65 2.57e-77 Cognitive function; BRCA cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.19 -0.43 6.96e-31 Electroencephalogram traits; BRCA cis rs724568 0.509 rs10203976 chr2:67941638 T/G cg14046302 chr2:67939758 NA -0.4 -10.95 -0.4 1.06e-25 Major depressive disorder (broad); BRCA cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg10802521 chr3:52805072 NEK4 -0.33 -8.47 -0.32 1.73e-16 Bipolar disorder; BRCA cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg01939980 chr4:1354348 KIAA1530 -0.32 -8.77 -0.33 1.56e-17 Obesity-related traits; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.92 -0.3 1.05e-14 Total body bone mineral density; BRCA cis rs9400271 0.527 rs4946954 chr6:109639656 A/G cg01475377 chr6:109611718 NA -0.37 -8.32 -0.31 5.32e-16 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg05025164 chr4:1340916 KIAA1530 0.6 12.33 0.44 1.82e-31 Longevity; BRCA cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs208520 0.560 rs2351880 chr6:66863707 G/A cg07460842 chr6:66804631 NA -1.02 -19.91 -0.62 5.44e-69 Exhaled nitric oxide output; BRCA cis rs2797160 0.651 rs1268093 chr6:126029235 C/T cg05901451 chr6:126070800 HEY2 0.48 12.02 0.43 3.69e-30 Endometrial cancer; BRCA cis rs9486719 0.843 rs2499792 chr6:96846264 A/C cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs3857067 0.806 rs6825522 chr4:95108140 G/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.34 -0.35 1.56e-19 QT interval; BRCA cis rs826838 1.000 rs826888 chr12:39104719 C/G cg26384229 chr12:38710491 ALG10B -0.63 -16.51 -0.55 2.79e-51 Heart rate; BRCA cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs4363385 0.620 rs4388644 chr1:152983674 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.52e-16 Inflammatory skin disease; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg08132940 chr7:1081526 C7orf50 -0.58 -8.81 -0.33 1.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 17.75 0.57 1.25e-57 Alzheimer's disease; BRCA cis rs9287719 0.967 rs6751398 chr2:10738972 T/C cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.37 0.61 3.91e-66 Cognitive function; BRCA cis rs7582180 0.591 rs11674569 chr2:101010860 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.5 0.41 5.78e-28 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg05084668 chr3:125655381 ALG1L -0.47 -8.1 -0.31 2.77e-15 Blood pressure (smoking interaction); BRCA cis rs2243480 1.000 rs316307 chr7:65570171 C/T cg18252515 chr7:66147081 NA -1.07 -15.35 -0.52 1.71e-45 Diabetic kidney disease; BRCA cis rs2762353 0.808 rs1184803 chr6:25834658 T/C cg03264133 chr6:25882463 NA -0.53 -11.93 -0.43 9.61e-30 Blood metabolite levels; BRCA cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg20503657 chr10:835505 NA 1.02 15.54 0.52 1.96e-46 Eosinophil percentage of granulocytes; BRCA cis rs9486719 1.000 rs11152951 chr6:96894135 C/G cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg00121533 chr1:75199117 CRYZ;TYW3 -0.52 -9.96 -0.37 8.35e-22 Resistin levels; BRCA cis rs881375 0.967 rs876445 chr9:123677102 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.43 0.32 2.29e-16 Rheumatoid arthritis; BRCA cis rs10751667 0.666 rs10902248 chr11:957742 A/G ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.22e-52 Alzheimer's disease (late onset); BRCA cis rs9527 0.614 rs11191589 chr10:104930382 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.12 0.37 1.97e-22 Arsenic metabolism; BRCA cis rs2046867 0.818 rs1502754 chr3:72895345 G/T cg25664220 chr3:72788482 NA -0.44 -10.0 -0.37 5.75e-22 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg26818010 chr10:134567672 INPP5A -0.77 -15.13 -0.51 1.95e-44 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs910316 0.763 rs735452 chr14:75497984 A/G cg11812906 chr14:75593930 NEK9 -0.65 -14.64 -0.5 4.74e-42 Height; BRCA cis rs12530845 0.673 rs73725437 chr7:135327853 G/A cg23117316 chr7:135346802 PL-5283 -0.39 -8.02 -0.3 5.07e-15 Red blood cell traits; BRCA cis rs11098499 0.954 rs11935596 chr4:120412457 G/C cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.91e-45 Corneal astigmatism; BRCA cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -12.62 -0.45 9.25e-33 Longevity; BRCA cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.31 0.49 1.76e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3733585 0.699 rs7694997 chr4:9947811 A/G cg11266682 chr4:10021025 SLC2A9 -0.42 -10.91 -0.4 1.51e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17685 0.712 rs11764119 chr7:75812358 T/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.29 -0.31 6.8e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg11822812 chr5:140052017 DND1 -0.3 -8.4 -0.32 2.8e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs10883723 0.847 rs3808934 chr10:104264280 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.91 0.62 5.12e-69 Allergic disease (asthma, hay fever or eczema); BRCA cis rs67981189 0.865 rs2810115 chr14:71394787 A/G cg15816911 chr14:71606274 NA -0.37 -8.23 -0.31 1.04e-15 Schizophrenia; BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg00106254 chr7:1943704 MAD1L1 -0.41 -11.19 -0.4 1.15e-26 Bipolar disorder and schizophrenia; BRCA cis rs11229555 0.645 rs11229430 chr11:58181104 G/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7412746 0.611 rs7556661 chr1:150892009 C/T cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.26e-14 Melanoma; BRCA cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.78 0.39 5.07e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg02297831 chr4:17616191 MED28 0.39 8.59 0.32 6.41e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4466137 1.000 rs4466137 chr5:82985739 A/C cg15083037 chr5:83017644 HAPLN1 -0.51 -10.07 -0.37 3.1e-22 Prostate cancer; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg00149659 chr3:10157352 C3orf10 1.06 17.88 0.58 2.77e-58 Alzheimer's disease; BRCA cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg24692254 chr21:30365293 RNF160 0.38 8.8 0.33 1.27e-17 Pancreatic cancer; BRCA cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg06784218 chr1:46089804 CCDC17 -0.44 -10.27 -0.38 5.21e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11105298 0.786 rs10858897 chr12:89922032 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -9.28 -0.34 2.53e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs7178375 1.000 rs7169064 chr15:31210862 C/T cg04373760 chr16:53404718 NA 0.47 8.78 0.33 1.53e-17 Hypertriglyceridemia; BRCA cis rs3741151 0.773 rs7925226 chr11:73137362 A/G cg17517138 chr11:73019481 ARHGEF17 0.88 12.73 0.45 3.1e-33 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs250677 0.687 rs1422581 chr5:148437386 C/T cg12140854 chr5:148520817 ABLIM3 0.42 9.19 0.34 5.51e-19 Breast cancer; BRCA cis rs6450176 1.000 rs3776715 chr5:53299095 T/C ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg13175981 chr1:150552382 MCL1 0.43 9.4 0.35 9.24e-20 Tonsillectomy; BRCA cis rs7246657 0.765 rs7247259 chr19:37851090 T/C cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg01483505 chr11:975446 AP2A2 0.33 8.98 0.33 2.93e-18 Alzheimer's disease (late onset); BRCA trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg26384229 chr12:38710491 ALG10B 0.68 14.33 0.49 1.34e-40 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs9379785 chr6:25726213 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs832540 0.669 rs832538 chr5:56200016 C/T cg20203395 chr5:56204925 C5orf35 -0.37 -8.52 -0.32 1.1e-16 Coronary artery disease; BRCA cis rs9469578 1.000 rs73743326 chr6:33709980 C/A cg18708504 chr6:33715942 IP6K3 0.71 10.36 0.38 2.31e-23 Phosphorus levels; BRCA cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11890956 chr21:40555474 PSMG1 0.94 21.62 0.65 3.39e-78 Cognitive function; BRCA cis rs7582720 1.000 rs72936353 chr2:204070956 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.22 0.44 5.16e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs6484504 0.600 rs2761593 chr11:31326752 G/T cg06552810 chr11:31128660 NA 0.37 8.52 0.32 1.18e-16 Red blood cell count; BRCA cis rs12410462 0.901 rs2814090 chr1:227658444 C/G cg04117972 chr1:227635322 NA -0.46 -8.39 -0.31 3.13e-16 Major depressive disorder; BRCA cis rs72627123 0.867 rs61522544 chr14:74481953 G/A cg12022184 chr14:74485813 ENTPD5;C14orf45 0.68 8.1 0.31 2.87e-15 Morning vs. evening chronotype; BRCA cis rs1994135 0.715 rs10844624 chr12:33691010 A/G cg06521331 chr12:34319734 NA -0.43 -7.89 -0.3 1.36e-14 Resting heart rate; BRCA cis rs10493773 0.775 rs12756013 chr1:86153532 C/T cg17807903 chr1:86174739 ZNHIT6 -0.45 -10.51 -0.38 6.16e-24 Urate levels in overweight individuals; BRCA cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg24642439 chr20:33292090 TP53INP2 0.53 11.5 0.41 5.99e-28 Glomerular filtration rate (creatinine); BRCA cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg07537917 chr2:241836409 C2orf54 -0.49 -11.69 -0.42 9.91e-29 Urinary metabolites; BRCA cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg04267008 chr7:1944627 MAD1L1 -0.51 -10.64 -0.39 1.82e-24 Bipolar disorder and schizophrenia; BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.5 7.97 0.3 7.32e-15 Renal function-related traits (BUN); BRCA cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg13010199 chr12:38710504 ALG10B 0.51 10.65 0.39 1.76e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs4363385 0.747 rs2339493 chr1:152975277 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.08e-24 Motion sickness; BRCA cis rs9790314 0.846 rs4856714 chr3:160961824 T/C cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.17e-59 Morning vs. evening chronotype; BRCA cis rs6582630 0.519 rs11495699 chr12:38286219 G/T cg26384229 chr12:38710491 ALG10B 0.79 17.92 0.58 1.7e-58 Drug-induced liver injury (flucloxacillin); BRCA cis rs7618915 0.501 rs1468638 chr3:52748058 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.86 0.45 7.85e-34 Bipolar disorder; BRCA trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.06 0.3 3.79e-15 Corneal astigmatism; BRCA cis rs1065852 0.526 rs9611711 chr22:42410695 G/A cg22189786 chr22:42395067 WBP2NL 0.41 8.07 0.3 3.52e-15 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA trans rs11098499 0.863 rs6833334 chr4:120504227 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.35 0.31 4.27e-16 Corneal astigmatism; BRCA cis rs829883 0.664 rs829864 chr12:98850195 C/T cg25150519 chr12:98850993 NA 0.68 16.49 0.55 3.84e-51 Colorectal adenoma (advanced); BRCA cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg26116260 chr4:7069785 GRPEL1 0.89 24.19 0.69 2.79e-92 Monocyte percentage of white cells; BRCA cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg11752832 chr7:134001865 SLC35B4 0.52 11.92 0.43 1.05e-29 Mean platelet volume; BRCA cis rs1505368 0.534 rs10185241 chr2:213244124 C/T cg20637307 chr2:213403960 ERBB4 0.33 7.89 0.3 1.28e-14 Symmetrical dimethylarginine levels; BRCA cis rs4268898 0.552 rs12621083 chr2:24367540 C/T cg26838691 chr2:24397539 C2orf84 0.39 7.96 0.3 8.05e-15 Asthma; BRCA cis rs7246657 0.943 rs4803460 chr19:37885228 T/C cg23950597 chr19:37808831 NA -0.63 -11.53 -0.41 4.51e-28 Coronary artery calcification; BRCA cis rs1707322 0.963 rs11211229 chr1:46400517 A/C cg03146154 chr1:46216737 IPP 0.46 10.2 0.37 9.95e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24531977 chr5:56204891 C5orf35 0.72 16.03 0.54 7.19e-49 Initial pursuit acceleration; BRCA cis rs3771570 1.000 rs17386555 chr2:242371825 G/A cg21155796 chr2:242212141 HDLBP 0.63 9.54 0.35 3e-20 Prostate cancer; BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg05863683 chr7:1912471 MAD1L1 0.37 8.49 0.32 1.4e-16 Bipolar disorder and schizophrenia; BRCA cis rs7267979 0.966 rs2151144 chr20:25414924 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.89 -0.33 6.44e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 12.86 0.45 8.26e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -7.96 -0.3 7.93e-15 Total body bone mineral density; BRCA cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg19678392 chr7:94953810 PON1 -0.42 -8.93 -0.33 4.37e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.92 -0.45 4.51e-34 Lymphocyte counts; BRCA cis rs4363385 0.747 rs6671414 chr1:152974119 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.84 -0.36 2.32e-21 Inflammatory skin disease; BRCA cis rs2953174 0.786 rs2953145 chr2:241515596 C/G cg07929629 chr2:241523174 NA -0.46 -8.61 -0.32 5.84e-17 Bipolar disorder; BRCA cis rs738322 0.555 rs2284063 chr22:38544298 C/T cg25457927 chr22:38595422 NA 0.37 13.54 0.47 6.32e-37 Cutaneous nevi; BRCA cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg03146154 chr1:46216737 IPP 0.45 9.99 0.37 6.25e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs12410462 1.000 rs80168344 chr1:227655804 C/T cg23173402 chr1:227635558 NA 0.53 9.62 0.36 1.46e-20 Major depressive disorder; BRCA cis rs208520 0.874 rs208518 chr6:66948501 C/G cg07460842 chr6:66804631 NA 0.9 15.91 0.53 2.84e-48 Exhaled nitric oxide output; BRCA cis rs7617773 0.780 rs13085251 chr3:48340045 C/T cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg08213375 chr14:104286397 PPP1R13B 0.42 9.07 0.34 1.43e-18 Reticulocyte count; BRCA cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.6 14.32 0.49 1.49e-40 Hemoglobin concentration; BRCA cis rs6120849 0.754 rs6088678 chr20:33607551 A/G cg24642439 chr20:33292090 TP53INP2 -0.6 -10.45 -0.38 1.04e-23 Protein C levels; BRCA cis rs7246657 0.943 rs9676967 chr19:37928089 G/C cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs8180040 0.805 rs17410853 chr3:47363971 G/T cg27129171 chr3:47204927 SETD2 -0.62 -14.06 -0.49 2.46e-39 Colorectal cancer; BRCA cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg11584989 chr19:19387371 SF4 0.62 14.04 0.49 3.03e-39 Bipolar disorder; BRCA cis rs10927875 0.800 rs1627145 chr1:16328116 C/T cg22431228 chr1:16359049 CLCNKA -0.4 -8.14 -0.31 2.15e-15 Dilated cardiomyopathy; BRCA cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs3806843 0.741 rs2563293 chr5:140110536 T/C cg26395211 chr5:140044315 WDR55 0.38 8.56 0.32 8.22e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.54 0.32 9.54e-17 Rheumatoid arthritis; BRCA cis rs6009527 0.752 rs7288176 chr22:49568462 A/G cg12746016 chr22:49560550 NA -0.42 -9.99 -0.37 6.04e-22 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); BRCA cis rs2882667 0.858 rs11957527 chr5:138404895 T/C cg04439458 chr5:138467593 SIL1 -0.41 -10.29 -0.38 4.4e-23 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9462027 0.606 rs3777752 chr6:34772212 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 1.98e-14 Systemic lupus erythematosus; BRCA cis rs7666738 0.785 rs11944120 chr4:99079932 A/C cg05340658 chr4:99064831 C4orf37 0.51 9.74 0.36 5.42e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs921968 0.565 rs12611632 chr2:219621258 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 3.78e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg18876405 chr7:65276391 NA -0.55 -13.42 -0.47 2.26e-36 Aortic root size; BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.67 0.42 1.15e-28 Tonsillectomy; BRCA cis rs2732480 0.557 rs2634682 chr12:48732943 T/C cg04545296 chr12:48745243 ZNF641 0.25 8.2 0.31 1.33e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 13.49 0.47 1.13e-36 Personality dimensions; BRCA cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.51 9.52 0.35 3.35e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg25703541 chr22:24373054 LOC391322 -0.66 -14.5 -0.5 2.07e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg08085267 chr17:45401833 C17orf57 -0.66 -14.62 -0.5 6.05e-42 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3806843 0.735 rs778597 chr5:140040665 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.46 -10.66 -0.39 1.6e-24 Depressive symptoms (multi-trait analysis); BRCA cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg18876405 chr7:65276391 NA 0.5 11.1 0.4 2.7e-26 Aortic root size; BRCA cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.49 0.41 6.46e-28 Bipolar disorder; BRCA cis rs1348850 0.526 rs4893829 chr2:178399810 A/G cg27490568 chr2:178487706 NA -0.5 -8.4 -0.32 2.92e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4319547 0.737 rs10773176 chr12:122944713 A/G cg23029597 chr12:123009494 RSRC2 -0.46 -9.34 -0.35 1.58e-19 Body mass index; BRCA cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg11663144 chr21:46675770 NA -0.6 -13.87 -0.48 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7766436 0.885 rs1954272 chr6:22586499 A/G cg13666174 chr6:22585274 NA -0.48 -11.34 -0.41 2.75e-27 Coronary artery disease; BRCA cis rs10751667 0.600 rs10751665 chr11:941300 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.19e-47 Alzheimer's disease (late onset); BRCA cis rs17270561 0.723 rs12192635 chr6:25880907 A/T cg17691542 chr6:26056736 HIST1H1C 0.69 14.14 0.49 1.08e-39 Iron status biomarkers; BRCA cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg18876405 chr7:65276391 NA 0.63 15.51 0.52 2.79e-46 Aortic root size; BRCA trans rs11098499 0.779 rs7356491 chr4:120381974 C/T cg25214090 chr10:38739885 LOC399744 0.54 12.59 0.45 1.29e-32 Corneal astigmatism; BRCA trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg17830980 chr10:43048298 ZNF37B -0.53 -12.81 -0.45 1.36e-33 Extrinsic epigenetic age acceleration; BRCA cis rs2404618 0.506 rs12156177 chr8:1493684 C/T cg13402656 chr8:1511478 DLGAP2 -0.44 -10.42 -0.38 1.41e-23 Lung cancer; BRCA cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg20891283 chr12:69753455 YEATS4 0.72 21.14 0.64 1.26e-75 Blood protein levels; BRCA trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg15556689 chr8:8085844 FLJ10661 -0.36 -9.58 -0.35 2.08e-20 Monocyte count; BRCA cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg16339924 chr4:17578868 LAP3 0.63 15.65 0.53 5.38e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2204008 0.811 rs12368410 chr12:38305705 C/T cg06521331 chr12:34319734 NA -0.52 -9.55 -0.35 2.81e-20 Bladder cancer; BRCA cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg14844989 chr11:31128820 NA -0.45 -9.56 -0.35 2.55e-20 Red blood cell count; BRCA cis rs1577917 1.000 rs12200330 chr6:86656653 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -13.47 -0.47 1.39e-36 Response to antipsychotic treatment; BRCA cis rs12579753 0.917 rs10862360 chr12:82187411 A/G cg07988820 chr12:82153109 PPFIA2 -0.49 -8.57 -0.32 7.74e-17 Resting heart rate; BRCA cis rs2066819 1.000 rs78495928 chr12:56635080 G/C cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA trans rs8073060 0.545 rs3859282 chr17:34006111 T/C cg19694781 chr19:47549865 TMEM160 -1.03 -21.09 -0.64 2.33e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg04450456 chr4:17643702 FAM184B 0.33 9.62 0.36 1.44e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7264396 0.790 rs6058288 chr20:34228680 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.37 -7.98 -0.3 6.78e-15 Total cholesterol levels; BRCA cis rs7092929 0.883 rs651750 chr10:3577178 A/G cg14308648 chr10:3568949 NA 0.41 7.85 0.3 1.73e-14 Coronary artery calcification; BRCA cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg11890956 chr21:40555474 PSMG1 -0.62 -13.8 -0.48 4.27e-38 Menarche (age at onset); BRCA cis rs2070488 0.965 rs13097628 chr3:38521156 T/C cg24069376 chr3:38537580 EXOG 0.41 11.81 0.42 2.91e-29 Electrocardiographic conduction measures; BRCA cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg22307029 chr19:49891270 CCDC155 -0.47 -8.13 -0.31 2.22e-15 Multiple sclerosis; BRCA trans rs11039798 0.764 rs12277213 chr11:48782176 G/A cg15704280 chr7:45808275 SEPT13 0.59 8.86 0.33 8.1e-18 Axial length; BRCA cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg13628971 chr7:2884303 GNA12 0.6 13.62 0.47 2.96e-37 Height; BRCA trans rs6952808 1.000 rs6978048 chr7:1886872 T/G cg04565464 chr8:145669602 NFKBIL2 0.37 8.14 0.31 2.09e-15 Bipolar disorder and schizophrenia; BRCA cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg13556452 chr1:2391241 NA -0.34 -8.08 -0.3 3.27e-15 Schizophrenia; BRCA cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg27211696 chr2:191398769 TMEM194B 0.5 11.59 0.42 2.53e-28 Pulse pressure; BRCA cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.49 0.32 1.45e-16 Diabetic retinopathy; BRCA cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg24642439 chr20:33292090 TP53INP2 0.61 13.48 0.47 1.27e-36 Coronary artery disease; BRCA cis rs8068544 0.818 rs8079958 chr17:40155467 C/T cg18442075 chr17:40169520 DNAJC7;NKIRAS2 -1.07 -14.42 -0.5 5.18e-41 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs28830936 1.000 rs17678138 chr15:42043067 G/A cg17847044 chr15:42102381 MAPKBP1 -0.37 -11.34 -0.41 2.69e-27 Diastolic blood pressure; BRCA cis rs61935443 0.832 rs7308359 chr12:95272904 G/T cg21533806 chr12:95267307 NA 0.46 8.8 0.33 1.26e-17 Schizophrenia; BRCA trans rs11098499 0.754 rs17595608 chr4:120250506 C/T cg25214090 chr10:38739885 LOC399744 0.46 10.55 0.39 4.16e-24 Corneal astigmatism; BRCA cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg10820045 chr2:198174542 NA -0.41 -9.35 -0.35 1.42e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.4 8.44 0.32 2.05e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg12863693 chr15:85201151 NMB -0.33 -7.93 -0.3 9.7e-15 P wave terminal force; BRCA cis rs17641971 0.645 rs186891 chr8:50038758 T/C cg00325661 chr8:49890786 NA 0.35 9.51 0.35 3.71e-20 Blood metabolite levels; BRCA cis rs2629540 0.781 rs11245362 chr10:126458649 T/C cg08799069 chr10:126477246 METTL10 -0.53 -11.66 -0.42 1.29e-28 Cocaine dependence; BRCA cis rs67460515 0.500 rs9832109 chr3:160723364 T/C cg03342759 chr3:160939853 NMD3 -0.6 -11.99 -0.43 5.24e-30 Parkinson's disease; BRCA cis rs681343 1.000 rs681343 chr19:49206462 C/T cg21064579 chr19:49206444 FUT2 0.37 9.3 0.35 2.18e-19 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs7085104 0.660 rs7902804 chr10:104585405 A/T cg04362960 chr10:104952993 NT5C2 0.38 8.9 0.33 5.58e-18 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg01475377 chr6:109611718 NA -0.59 -16.41 -0.54 9.2e-51 Reticulocyte fraction of red cells; BRCA cis rs2832191 0.935 rs11910316 chr21:30519729 G/A cg24692254 chr21:30365293 RNF160 -0.6 -15.77 -0.53 1.51e-47 Dental caries; BRCA cis rs7586879 0.789 rs13398155 chr2:25128550 C/T cg01884057 chr2:25150051 NA 0.31 7.89 0.3 1.34e-14 Body mass index; BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg05793240 chr7:2802953 GNA12 -0.34 -8.65 -0.32 4.22e-17 Height; BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg21226059 chr5:178986404 RUFY1 -0.48 -13.5 -0.47 1.06e-36 Lung cancer; BRCA cis rs4919694 0.808 rs4918001 chr10:105013147 G/T cg04362960 chr10:104952993 NT5C2 -0.79 -12.89 -0.45 5.62e-34 Arsenic metabolism; BRCA cis rs7592578 0.640 rs56127319 chr2:191296429 G/A cg11845111 chr2:191398756 TMEM194B -0.73 -13.84 -0.48 2.62e-38 Diastolic blood pressure; BRCA cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg08213375 chr14:104286397 PPP1R13B 0.63 17.14 0.56 1.79e-54 Schizophrenia; BRCA cis rs757081 0.634 rs17472942 chr11:17094702 A/G cg15432903 chr11:17409602 KCNJ11 -0.46 -8.63 -0.32 4.87e-17 Systolic blood pressure; BRCA cis rs6964587 1.000 rs10274756 chr7:91740796 G/A cg01689657 chr7:91764605 CYP51A1 0.22 7.91 0.3 1.13e-14 Breast cancer; BRCA cis rs7011049 0.908 rs11986701 chr8:53833480 G/T cg26025543 chr8:53854495 NA 0.54 9.85 0.36 2.09e-21 Systolic blood pressure; BRCA trans rs11088226 0.681 rs9622 chr21:33951068 T/C cg09050820 chr6:167586206 TCP10L2 0.85 15.88 0.53 4.06e-48 Gastritis; BRCA cis rs10193935 0.901 rs59984817 chr2:42566909 C/G cg27598129 chr2:42591480 NA -0.91 -14.58 -0.5 9.14e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg03264133 chr6:25882463 NA -0.49 -11.01 -0.4 6.3e-26 Blood metabolite levels; BRCA cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg12591125 chr7:1885375 MAD1L1 0.52 9.02 0.34 2.24e-18 Bipolar disorder; BRCA cis rs2422052 0.729 rs967252 chr2:118643492 T/G cg22545206 chr2:118617499 NA 0.39 9.51 0.35 3.89e-20 Mosquito bite size; BRCA cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg04317338 chr11:64019027 PLCB3 0.57 9.71 0.36 7.01e-21 Mean platelet volume; BRCA cis rs35146811 0.735 rs858506 chr7:99820050 T/C cg13334819 chr7:99746414 C7orf59 0.39 9.01 0.34 2.32e-18 Coronary artery disease; BRCA cis rs2505998 0.833 rs1864403 chr10:43604950 C/T cg15436174 chr10:43711423 RASGEF1A 0.43 8.46 0.32 1.85e-16 Hirschsprung disease; BRCA cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg20701182 chr2:24300061 SF3B14 0.71 13.25 0.46 1.48e-35 Lymphocyte counts; BRCA cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg11366901 chr6:160182831 ACAT2 0.83 16.16 0.54 1.67e-49 Age-related macular degeneration (geographic atrophy); BRCA trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg03929089 chr4:120376271 NA 0.48 8.1 0.31 2.74e-15 Axial length; BRCA cis rs250677 1.000 rs36069 chr5:148417253 G/C cg12140854 chr5:148520817 ABLIM3 -0.42 -8.98 -0.33 3.02e-18 Breast cancer; BRCA cis rs1865760 0.963 rs1540273 chr6:25924158 T/C cg16482183 chr6:26056742 HIST1H1C 0.55 11.35 0.41 2.61e-27 Height; BRCA cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg23649088 chr2:200775458 C2orf69 -0.63 -10.5 -0.38 6.71e-24 Schizophrenia; BRCA cis rs7246657 0.943 rs10420430 chr19:37894194 C/G cg18154014 chr19:37997991 ZNF793 0.62 11.61 0.42 2.07e-28 Coronary artery calcification; BRCA cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg19678392 chr7:94953810 PON1 -0.42 -8.62 -0.32 5.29e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs72781680 0.846 rs55707417 chr2:24029928 G/A cg08917208 chr2:24149416 ATAD2B 1.07 14.8 0.51 7.91e-43 Lymphocyte counts; BRCA cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg01877450 chr7:97915802 BRI3 -0.37 -8.29 -0.31 6.85e-16 Prostate cancer (SNP x SNP interaction); BRCA trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21659725 chr3:3221576 CRBN 0.71 21.66 0.65 1.89e-78 Intelligence (multi-trait analysis); BRCA cis rs7301826 1.000 rs10773822 chr12:131289107 C/G cg11011512 chr12:131303247 STX2 0.42 10.88 0.4 2.07e-25 Plasma plasminogen activator levels; BRCA cis rs6121246 0.647 rs6088855 chr20:30225792 C/T cg21427119 chr20:30132790 HM13 -0.42 -8.67 -0.32 3.64e-17 Mean corpuscular hemoglobin; BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg03709012 chr19:19516395 GATAD2A -0.81 -18.81 -0.6 4.03e-63 Tonsillectomy; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.44 -10.14 -0.37 1.62e-22 Lymphocyte counts; BRCA cis rs992157 0.735 rs13388024 chr2:219097773 A/G cg00012203 chr2:219082015 ARPC2 0.71 16.21 0.54 9.22e-50 Colorectal cancer; BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg23285459 chr7:2802560 GNA12 -0.36 -9.11 -0.34 1.08e-18 Height; BRCA cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg17063962 chr7:91808500 NA 0.54 12.28 0.44 2.93e-31 Breast cancer; BRCA cis rs1401999 0.898 rs4148564 chr3:183725982 C/T cg20387954 chr3:183756860 HTR3D 0.47 10.56 0.39 4e-24 Anterior chamber depth; BRCA trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.19 -0.34 5.5e-19 Extrinsic epigenetic age acceleration; BRCA cis rs7264396 0.836 rs1886695 chr20:34180535 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.57 11.98 0.43 5.73e-30 Total cholesterol levels; BRCA cis rs1577917 1.000 rs1018184 chr6:86648475 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 11.86 0.42 1.84e-29 Response to antipsychotic treatment; BRCA cis rs1878931 0.507 rs67218524 chr16:3403057 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.46 -8.12 -0.31 2.34e-15 Body mass index (adult); BRCA cis rs7267979 1.000 rs2482911 chr20:25395528 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.3 -8.05 -0.3 4.1e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1050631 0.564 rs1785934 chr18:33718326 A/C cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.99 -0.3 6.25e-15 Esophageal squamous cell cancer (length of survival); BRCA cis rs738322 0.640 rs738321 chr22:38568833 C/G cg20207973 chr22:38506712 BAIAP2L2 0.31 7.93 0.3 9.93e-15 Cutaneous nevi; BRCA cis rs7631605 0.819 rs4678922 chr3:37022864 A/T cg15934958 chr3:37212084 LRRFIP2 0.42 9.82 0.36 2.61e-21 Cerebrospinal P-tau181p levels; BRCA cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg22875332 chr1:76189707 ACADM -0.54 -10.17 -0.37 1.32e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg22455342 chr2:225449267 CUL3 -0.63 -15.82 -0.53 7.95e-48 IgE levels in asthmatics (D.p. specific); BRCA trans rs1994135 0.647 rs1351681 chr12:33698724 G/A cg26384229 chr12:38710491 ALG10B 0.59 11.85 0.42 1.94e-29 Resting heart rate; BRCA cis rs6867032 1.000 rs28392808 chr5:2013477 A/G cg26168224 chr5:2018326 NA 0.64 17.98 0.58 8.6e-59 Gut microbiome composition (winter); BRCA cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs12618769 0.597 rs4851140 chr2:99079339 T/C cg10123293 chr2:99228465 UNC50 0.41 8.09 0.3 3.05e-15 Bipolar disorder; BRCA cis rs73198271 0.740 rs10092600 chr8:8649023 A/G cg15556689 chr8:8085844 FLJ10661 -0.32 -7.85 -0.3 1.78e-14 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg12564285 chr5:131593104 PDLIM4 0.36 9.68 0.36 9.33e-21 Breast cancer; BRCA cis rs9463078 0.683 rs227850 chr6:44699068 C/T cg25276700 chr6:44698697 NA 0.36 7.94 0.3 9.19e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs27434 0.539 rs40604 chr5:96155900 G/A cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.22e-33 Ankylosing spondylitis; BRCA cis rs1568889 0.838 rs11030230 chr11:28174631 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.62 0.63 8.22e-73 Bipolar disorder; BRCA cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg26597838 chr10:835615 NA 0.96 14.45 0.5 3.55e-41 Eosinophil percentage of granulocytes; BRCA trans rs11039798 0.588 rs6485869 chr11:48576903 G/T cg03929089 chr4:120376271 NA 0.47 7.94 0.3 9.07e-15 Axial length; BRCA cis rs12310956 0.532 rs7306007 chr12:33975209 C/G cg06521331 chr12:34319734 NA -0.56 -11.0 -0.4 6.82e-26 Morning vs. evening chronotype; BRCA cis rs35123781 0.955 rs34530707 chr5:139059016 G/A cg05227215 chr5:139057496 CXXC5 0.36 8.67 0.32 3.66e-17 Schizophrenia; BRCA cis rs6435161 1.000 rs6748088 chr2:203556526 A/G cg18429434 chr2:203499731 FAM117B -0.44 -8.78 -0.33 1.54e-17 Total cholesterol levels; BRCA cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg13256891 chr4:100009986 ADH5 -0.5 -9.53 -0.35 3.33e-20 Smoking initiation; BRCA trans rs800082 0.668 rs7643301 chr3:144293612 G/A cg24215973 chr2:240111563 HDAC4 -0.43 -10.32 -0.38 3.26e-23 Smoking behavior; BRCA cis rs28374715 0.681 rs8037574 chr15:41630770 T/C cg18705301 chr15:41695430 NDUFAF1 -0.81 -18.93 -0.6 8.94e-64 Ulcerative colitis; BRCA cis rs4363385 0.747 rs1577962 chr1:152962013 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 4.06e-16 Inflammatory skin disease; BRCA cis rs875971 0.862 rs2420611 chr7:65999320 A/G cg11764359 chr7:65958608 NA 0.76 16.83 0.55 7.34e-53 Aortic root size; BRCA cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs999943 0.846 rs1570760 chr6:33622933 C/T cg14003231 chr6:33640908 ITPR3 0.67 15.06 0.51 4.43e-44 Obesity (extreme); BRCA cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.68e-24 Motion sickness; BRCA cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg24642439 chr20:33292090 TP53INP2 0.52 11.43 0.41 1.2e-27 Glomerular filtration rate (creatinine); BRCA cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg04450456 chr4:17643702 FAM184B 0.31 9.06 0.34 1.52e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7255436 0.965 rs7254882 chr19:8453822 A/G cg10811474 chr19:8428787 ANGPTL4 -0.31 -7.86 -0.3 1.69e-14 HDL cholesterol; BRCA cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.24 0.31 9.64e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24110177 chr3:50126178 RBM5 -0.36 -9.59 -0.35 1.96e-20 Intelligence (multi-trait analysis); BRCA cis rs4481887 1.000 rs10888356 chr1:248465044 C/T cg00666640 chr1:248458726 OR2T12 -0.31 -8.54 -0.32 1.01e-16 Common traits (Other); BRCA cis rs78707713 0.560 rs61848397 chr10:71225584 C/A cg12610070 chr10:71211762 TSPAN15 -0.33 -10.15 -0.37 1.54e-22 Venous thromboembolism; BRCA cis rs4363385 0.818 rs558363 chr1:153010431 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg04315214 chr1:2043799 PRKCZ -0.47 -12.52 -0.44 2.44e-32 Height; BRCA cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg26248373 chr2:1572462 NA -0.63 -14.68 -0.5 2.88e-42 IgG glycosylation; BRCA cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg01236616 chr12:121019343 POP5 1.25 27.71 0.74 1.32e-111 Type 1 diabetes nephropathy; BRCA cis rs11051970 0.636 rs325424 chr12:32570193 C/T cg02745156 chr12:32552066 NA 0.25 8.27 0.31 7.81e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg19077165 chr18:44547161 KATNAL2 -0.58 -12.91 -0.45 4.74e-34 Personality dimensions; BRCA cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg06618935 chr21:46677482 NA 0.37 8.45 0.32 1.9e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 0.943 rs10417844 chr19:37837587 C/T cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.61 12.24 0.44 4.33e-31 Lymphocyte counts; BRCA cis rs4268898 0.552 rs35331966 chr2:24367828 C/T cg26838691 chr2:24397539 C2orf84 0.39 7.96 0.3 8.05e-15 Asthma; BRCA cis rs7572733 0.534 rs734037 chr2:198749269 G/A cg00792783 chr2:198669748 PLCL1 0.47 10.25 0.38 6.42e-23 Dermatomyositis; BRCA cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg11584989 chr19:19387371 SF4 -0.64 -13.77 -0.48 5.92e-38 Bipolar disorder; BRCA cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.28 -0.31 7.47e-16 Bipolar disorder; BRCA cis rs6963495 0.818 rs55922564 chr7:105155890 G/A cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg05472934 chr7:22766657 IL6 -0.55 -14.63 -0.5 5.25e-42 Lung cancer; BRCA cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs6484504 0.625 rs7940420 chr11:31366700 T/A cg26647111 chr11:31128758 NA 0.43 9.25 0.34 3.3e-19 Red blood cell count; BRCA cis rs4919087 1.000 rs7078288 chr10:99086361 C/T cg25902810 chr10:99078978 FRAT1 -0.45 -9.49 -0.35 4.33e-20 Monocyte count; BRCA trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg11693508 chr17:37793320 STARD3 0.57 10.84 0.39 2.88e-25 Bipolar disorder; BRCA cis rs9790314 0.905 rs7632797 chr3:161002694 C/T cg04691961 chr3:161091175 C3orf57 0.58 14.23 0.49 3.92e-40 Morning vs. evening chronotype; BRCA cis rs28374715 0.662 rs113913466 chr15:41483100 A/G cg18705301 chr15:41695430 NDUFAF1 -0.87 -18.16 -0.58 9.85e-60 Ulcerative colitis; BRCA cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg11764359 chr7:65958608 NA -0.75 -16.67 -0.55 4.55e-52 Aortic root size; BRCA cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg18964960 chr10:1102726 WDR37 -0.48 -8.59 -0.32 6.65e-17 Response to angiotensin II receptor blocker therapy; BRCA cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg11366901 chr6:160182831 ACAT2 0.7 13.8 0.48 4.34e-38 Age-related macular degeneration (geographic atrophy); BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg27170947 chr2:26402098 FAM59B -0.81 -12.91 -0.45 5e-34 Gut microbiome composition (summer); BRCA trans rs1005277 0.505 rs7917943 chr10:38195811 T/A cg17830980 chr10:43048298 ZNF37B 0.43 10.03 0.37 4.21e-22 Extrinsic epigenetic age acceleration; BRCA cis rs155076 1.000 rs155076 chr13:21870114 A/G cg14456004 chr13:21872349 NA -1.14 -21.74 -0.65 7.13e-79 White matter hyperintensity burden; BRCA cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs514406 0.505 rs269289 chr1:53167151 A/C cg24675658 chr1:53192096 ZYG11B -0.6 -14.38 -0.49 8.36e-41 Monocyte count; BRCA cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.38e-32 Breast cancer; BRCA cis rs7715811 1.000 rs1502050 chr5:13779743 A/G cg07548982 chr5:13769939 DNAH5 -0.38 -8.63 -0.32 4.86e-17 Subclinical atherosclerosis traits (other); BRCA cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg25174290 chr11:3078921 CARS 0.43 12.97 0.46 2.53e-34 Longevity; BRCA cis rs10733682 0.524 rs10987418 chr9:129462563 A/G cg00232160 chr9:129468157 NA 0.35 8.03 0.3 4.62e-15 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg08392591 chr16:89556376 ANKRD11 -0.39 -8.97 -0.33 3.39e-18 Multiple myeloma (IgH translocation); BRCA cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.04 -0.54 6.86e-49 Alzheimer's disease (late onset); BRCA cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 8.78e-16 Height; BRCA cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg19717773 chr7:2847554 GNA12 -0.43 -9.69 -0.36 8.32e-21 Height; BRCA cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.64 -0.36 1.27e-20 Alcohol dependence; BRCA cis rs9462027 0.628 rs58671447 chr6:34752351 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.2e-15 Systemic lupus erythematosus; BRCA cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg14844989 chr11:31128820 NA -0.45 -9.77 -0.36 4.21e-21 Red blood cell count; BRCA cis rs13096357 0.520 rs17080319 chr3:48732480 T/C cg07636037 chr3:49044803 WDR6 -0.58 -8.29 -0.31 6.64e-16 Cognitive ability (multi-trait analysis); BRCA cis rs7666738 0.830 rs6823718 chr4:99063202 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.22e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs16854884 0.837 rs989665 chr3:143792854 C/T cg06585982 chr3:143692056 C3orf58 0.39 7.86 0.3 1.61e-14 Economic and political preferences (feminism/equality); BRCA cis rs2012796 0.957 rs8009083 chr14:81818289 A/G cg02996355 chr14:81879375 NA 0.4 8.08 0.3 3.14e-15 Night sleep phenotypes; BRCA cis rs4808199 0.901 rs12973258 chr19:19488718 T/C cg03709012 chr19:19516395 GATAD2A 1.1 20.81 0.64 7.57e-74 Nonalcoholic fatty liver disease; BRCA cis rs9287719 0.934 rs6721510 chr2:10751046 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.93 -0.3 9.52e-15 Prostate cancer; BRCA cis rs7927771 0.832 rs11601603 chr11:47401171 A/C cg20307385 chr11:47447363 PSMC3 -0.4 -8.48 -0.32 1.52e-16 Subjective well-being; BRCA cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.34 -0.35 1.55e-19 Menopause (age at onset); BRCA cis rs3806843 1.000 rs6898906 chr5:140169299 C/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.67e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs11605924 1.000 rs12794698 chr11:45871861 G/A ch.11.939596F chr11:45881766 CRY2 -0.46 -10.09 -0.37 2.55e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs7618501 1.000 rs2271960 chr3:49878078 A/G cg21582582 chr3:182698605 DCUN1D1 0.36 9.48 0.35 5.09e-20 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.71e-21 Menopause (age at onset); BRCA cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg09469691 chr10:81107165 PPIF 0.43 9.39 0.35 1.02e-19 Height; BRCA cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg17845761 chr1:175162550 KIAA0040 0.26 9.9 0.36 1.35e-21 Alcohol dependence; BRCA cis rs10911251 0.509 rs4652780 chr1:183105923 G/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.38 0.54 1.25e-50 Colorectal cancer; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.57 -0.35 2.21e-20 Total body bone mineral density; BRCA cis rs2795502 0.882 rs2744095 chr10:43337949 A/T cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs2625529 0.586 rs2306489 chr15:72227471 G/A cg16672083 chr15:72433130 SENP8 0.69 16.74 0.55 2.04e-52 Red blood cell count; BRCA cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -7.95 -0.3 8.78e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9296092 0.517 rs55963187 chr6:33523778 G/C cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 20.35 0.63 2.32e-71 Platelet count; BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.79 0.48 4.84e-38 Platelet count; BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs7267979 0.816 rs6115094 chr20:25210827 A/G cg08601574 chr20:25228251 PYGB 0.35 8.28 0.31 7.22e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2880765 0.525 rs35899940 chr15:86053697 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -7.82 -0.3 2.12e-14 Coronary artery disease; BRCA cis rs1595825 0.945 rs7581202 chr2:198836777 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.12 -0.31 2.35e-15 Ulcerative colitis; BRCA trans rs35110281 0.837 rs2838340 chr21:45076373 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.37 8.11 0.31 2.57e-15 Mean corpuscular volume; BRCA cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.09 0.49 1.82e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg11764359 chr7:65958608 NA -0.77 -17.65 -0.57 4.23e-57 Aortic root size; BRCA cis rs4742903 0.935 rs1507515 chr9:106989653 A/G cg14250997 chr9:106856677 SMC2 -0.3 -9.31 -0.35 1.97e-19 High-grade serous ovarian cancer;Breast cancer; BRCA trans rs11098499 0.874 rs6822498 chr4:120120183 T/C cg25214090 chr10:38739885 LOC399744 0.51 10.5 0.38 6.89e-24 Corneal astigmatism; BRCA cis rs2153535 0.584 rs62395677 chr6:8371589 G/A cg07606381 chr6:8435919 SLC35B3 -0.57 -12.19 -0.43 7.19e-31 Motion sickness; BRCA cis rs12220238 1.000 rs4320897 chr10:76017732 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.49 8.1 0.31 2.72e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs12368653 0.545 rs2277324 chr12:58013175 G/A cg12615879 chr12:58013172 SLC26A10 0.39 10.74 0.39 7.5e-25 Multiple sclerosis; BRCA cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg24578937 chr1:2090814 PRKCZ -0.33 -10.31 -0.38 3.82e-23 Height; BRCA trans rs66887589 0.627 rs3872807 chr4:120360251 T/A cg25214090 chr10:38739885 LOC399744 0.36 8.2 0.31 1.29e-15 Diastolic blood pressure; BRCA cis rs9309711 0.623 rs7569694 chr2:3483390 T/G cg08493051 chr2:3487164 NA -0.43 -9.22 -0.34 4.1e-19 Neurofibrillary tangles; BRCA cis rs10876993 0.928 rs7136269 chr12:58075937 G/A cg18357645 chr12:58087776 OS9 0.47 13.55 0.47 6.3e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -9.19 -0.34 5.31e-19 Schizophrenia; BRCA cis rs2243480 1.000 rs1167613 chr7:65487439 C/T cg18252515 chr7:66147081 NA -0.85 -12.36 -0.44 1.23e-31 Diabetic kidney disease; BRCA cis rs2777491 0.915 rs28583065 chr15:41608470 T/C cg18705301 chr15:41695430 NDUFAF1 -0.62 -14.1 -0.49 1.67e-39 Ulcerative colitis; BRCA cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg11764359 chr7:65958608 NA 0.65 11.9 0.43 1.21e-29 Aortic root size; BRCA cis rs11051970 0.636 rs2651368 chr12:32561506 T/C cg02745156 chr12:32552066 NA 0.25 8.4 0.32 2.93e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs3857067 0.772 rs4692999 chr4:95107644 T/C cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.34 -0.35 1.56e-19 QT interval; BRCA cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg21475434 chr5:93447410 FAM172A -0.69 -8.9 -0.33 5.94e-18 Diabetic retinopathy; BRCA trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.31 8.46 0.32 1.8e-16 Intelligence (multi-trait analysis); BRCA cis rs3771570 1.000 rs16843590 chr2:242298228 G/A cg21155796 chr2:242212141 HDLBP 0.6 9.37 0.35 1.26e-19 Prostate cancer; BRCA cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 17.29 0.56 3.16e-55 Hip circumference adjusted for BMI; BRCA cis rs2404602 0.532 rs744336 chr15:76674624 T/C cg23625390 chr15:77176239 SCAPER 0.45 11.19 0.4 1.1e-26 Blood metabolite levels; BRCA cis rs7666738 0.571 rs7683769 chr4:99091742 T/C cg05340658 chr4:99064831 C4orf37 0.49 10.82 0.39 3.59e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7903847 0.620 rs3737194 chr10:99130127 A/G cg08345082 chr10:99160200 RRP12 -0.28 -7.96 -0.3 7.88e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg08999081 chr20:33150536 PIGU 0.35 8.89 0.33 6e-18 Coronary artery disease; BRCA cis rs9487051 0.676 rs11964178 chr6:109562035 A/G cg01475377 chr6:109611718 NA -0.38 -9.09 -0.34 1.25e-18 Reticulocyte fraction of red cells; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg16584290 chr5:462447 EXOC3 0.53 15.08 0.51 3.48e-44 Cystic fibrosis severity; BRCA cis rs752010 0.714 rs6658500 chr1:42088344 A/G cg06885757 chr1:42089581 HIVEP3 -0.29 -10.38 -0.38 2.0500000000000001e-23 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs208520 0.526 rs6913344 chr6:66754285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -29.08 -0.75 4.29e-119 Exhaled nitric oxide output; BRCA cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg21573476 chr21:45109991 RRP1B -0.32 -8.41 -0.32 2.69e-16 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.11e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg18876405 chr7:65276391 NA -0.64 -15.46 -0.52 4.91e-46 Calcium levels; BRCA cis rs9467773 1.000 rs10484442 chr6:26555879 A/G cg11502198 chr6:26597334 ABT1 0.47 9.39 0.35 1.03e-19 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg22800045 chr5:56110881 MAP3K1 0.62 11.83 0.42 2.4e-29 Initial pursuit acceleration; BRCA cis rs3771570 1.000 rs73002111 chr2:242277833 C/T cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg22920501 chr2:26401640 FAM59B -0.67 -11.06 -0.4 3.98e-26 Gut microbiome composition (summer); BRCA trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg23505145 chr19:12996616 KLF1 0.56 12.86 0.45 7.8e-34 Prostate cancer (SNP x SNP interaction); BRCA trans rs853679 0.607 rs34691223 chr6:28258208 C/A cg06606381 chr12:133084897 FBRSL1 -0.82 -8.75 -0.33 1.83e-17 Depression; BRCA cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg26384229 chr12:38710491 ALG10B -0.5 -13.02 -0.46 1.56e-34 Morning vs. evening chronotype; BRCA cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg13902645 chr11:5959945 NA 0.52 10.35 0.38 2.69e-23 DNA methylation (variation); BRCA cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg00750074 chr16:89608354 SPG7 -0.36 -9.58 -0.35 2.03e-20 Multiple myeloma (IgH translocation); BRCA cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24308560 chr3:49941425 MST1R -0.41 -8.67 -0.32 3.58e-17 Intelligence (multi-trait analysis); BRCA trans rs8073060 0.586 rs4795086 chr17:34042190 G/A cg19694781 chr19:47549865 TMEM160 1.05 20.27 0.63 6.46e-71 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg16325326 chr1:53192061 ZYG11B -0.95 -26.1 -0.72 8.67e-103 Monocyte count; BRCA trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg00717180 chr2:96193071 NA -0.38 -10.08 -0.37 2.87e-22 Height; BRCA trans rs4650994 1.000 rs4354501 chr1:178524596 T/C cg05059571 chr16:84539110 KIAA1609 -0.42 -9.47 -0.35 5.14e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6820391 0.663 rs10021838 chr4:54448833 A/G cg04173182 chr4:54446035 LNX1 0.47 10.71 0.39 9.76e-25 Cervical artery dissection; BRCA cis rs698833 0.548 rs6544760 chr2:44553014 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.43 0.32 2.33e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9287719 0.967 rs10167129 chr2:10758575 G/A cg00105475 chr2:10696890 NA 0.44 10.3 0.38 4.11e-23 Prostate cancer; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg12444411 chr7:2802554 GNA12 -0.35 -8.79 -0.33 1.37e-17 Height; BRCA cis rs1030877 0.515 rs2576735 chr2:105888839 C/T cg02079111 chr2:105885981 TGFBRAP1 0.65 12.56 0.45 1.68e-32 Obesity-related traits; BRCA cis rs736801 0.759 rs11741255 chr5:131811182 G/A cg14196790 chr5:131705035 SLC22A5 0.41 9.58 0.35 2.02e-20 Breast cancer;Mosquito bite size; BRCA cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg24690094 chr11:67383802 NA 0.44 9.5 0.35 4.12e-20 Mean corpuscular volume; BRCA cis rs2243480 1.000 rs36068983 chr7:65408991 C/T cg18252515 chr7:66147081 NA -0.84 -12.12 -0.43 1.34e-30 Diabetic kidney disease; BRCA cis rs12549902 1.000 rs12550613 chr8:41510260 G/C cg21772509 chr8:41503840 NKX6-3 0.48 11.25 0.41 6.71e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs11098499 0.874 rs7661020 chr4:120106982 T/C cg09307838 chr4:120376055 NA 0.6 11.04 0.4 4.7e-26 Corneal astigmatism; BRCA cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.34 0.41 2.89e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg17971929 chr21:40555470 PSMG1 0.75 16.14 0.54 2.12e-49 Cognitive function; BRCA trans rs8073060 0.544 rs225274 chr17:33971221 C/T cg19694781 chr19:47549865 TMEM160 0.96 20.65 0.63 5.71e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9818758 0.545 rs55921200 chr3:49189316 T/C cg00383909 chr3:49044727 WDR6 0.96 13.25 0.46 1.39e-35 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs66573146 0.831 rs6851488 chr4:6987412 C/T cg00086871 chr4:6988644 TBC1D14 0.93 14.54 0.5 1.41e-41 Granulocyte percentage of myeloid white cells; BRCA cis rs28374715 0.681 rs59000092 chr15:41626148 A/G cg18705301 chr15:41695430 NDUFAF1 -0.81 -18.94 -0.6 8e-64 Ulcerative colitis; BRCA cis rs2455799 0.613 rs2166759 chr3:15856285 A/G cg16303742 chr3:15540471 COLQ 0.38 9.2 0.34 4.91e-19 Mean platelet volume; BRCA cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg00531865 chr16:30841666 NA -0.38 -8.88 -0.33 6.55e-18 Dementia with Lewy bodies; BRCA cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg23711669 chr6:146136114 FBXO30 0.76 17.46 0.57 3.96e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.34 -0.31 4.53e-16 Total body bone mineral density; BRCA trans rs7615952 0.641 rs60839048 chr3:125807938 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -10.82 -0.39 3.47e-25 Blood pressure (smoking interaction); BRCA cis rs586533 0.837 rs627917 chr11:99503825 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.31 2.78e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg07395648 chr5:131743802 NA -0.37 -8.17 -0.31 1.7e-15 Breast cancer; BRCA cis rs701145 0.585 rs6769099 chr3:153852442 T/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs11229555 0.609 rs11229434 chr11:58185501 C/T cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg01448562 chr3:133502909 NA -0.41 -9.48 -0.35 4.98e-20 Iron status biomarkers; BRCA cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg26647111 chr11:31128758 NA -0.44 -9.62 -0.36 1.5e-20 Red blood cell count; BRCA cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.32 0.31 5.28e-16 Mean platelet volume; BRCA cis rs2635047 0.967 rs2576030 chr18:44659166 G/A cg19077165 chr18:44547161 KATNAL2 -0.42 -9.05 -0.34 1.68e-18 Educational attainment; BRCA cis rs67311347 0.955 rs9821036 chr3:40379007 A/G cg09455208 chr3:40491958 NA 0.4 9.41 0.35 8.63e-20 Renal cell carcinoma; BRCA trans rs4650994 1.000 rs17276527 chr1:178520680 G/A cg05059571 chr16:84539110 KIAA1609 -0.42 -9.6 -0.36 1.71e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs965469 1.000 rs6051737 chr20:3296992 G/A cg25506879 chr20:3388711 C20orf194 -0.51 -10.13 -0.37 1.77e-22 IFN-related cytopenia; BRCA cis rs72781680 1.000 rs72781653 chr2:24215633 T/C cg08917208 chr2:24149416 ATAD2B 0.91 13.2 0.46 2.28e-35 Lymphocyte counts; BRCA cis rs2882667 0.537 rs13181793 chr5:138408956 G/A cg04439458 chr5:138467593 SIL1 -0.33 -8.99 -0.33 2.89e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7523050 0.908 rs12404382 chr1:109397129 G/A cg08274380 chr1:109419600 GPSM2 0.84 12.88 0.45 6.8e-34 Fat distribution (HIV); BRCA cis rs17376456 0.778 rs10440717 chr5:93424852 C/A cg21475434 chr5:93447410 FAM172A 0.69 9.27 0.34 2.78e-19 Diabetic retinopathy; BRCA cis rs6005807 0.719 rs7293232 chr22:29015590 T/G cg12565055 chr22:29076175 TTC28 0.49 9.33 0.35 1.65e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg11214544 chr1:2391121 NA -0.42 -9.87 -0.36 1.82e-21 Non-obstructive azoospermia; BRCA cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg21573476 chr21:45109991 RRP1B -0.35 -9.21 -0.34 4.54e-19 Mean corpuscular volume; BRCA cis rs12618769 0.597 rs2309390 chr2:99114310 T/C cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.53e-16 Bipolar disorder; BRCA cis rs10193935 1.000 rs72796507 chr2:42409840 A/G cg27598129 chr2:42591480 NA -0.87 -14.04 -0.49 3.25e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg22963979 chr7:1858916 MAD1L1 0.37 8.03 0.3 4.87e-15 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs365132 0.818 rs6879982 chr5:176351330 A/T cg16309518 chr5:176445507 NA -0.37 -8.9 -0.33 5.58e-18 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg04025307 chr7:1156635 C7orf50 0.72 18.2 0.58 5.88e-60 Longevity;Endometriosis; BRCA cis rs6543140 0.964 rs6748390 chr2:103062175 A/G cg04239558 chr2:103089729 SLC9A4 0.34 9.43 0.35 7.61e-20 Blood protein levels; BRCA cis rs11971779 0.680 rs6954547 chr7:139054734 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs9300255 0.602 rs2695478 chr12:123689521 C/T cg00376283 chr12:123451042 ABCB9 0.56 10.81 0.39 3.86e-25 Neutrophil percentage of white cells; BRCA cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg18876405 chr7:65276391 NA 0.54 12.77 0.45 2.1e-33 Aortic root size; BRCA cis rs10883723 0.810 rs7094366 chr10:104274730 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.66 20.29 0.63 4.8e-71 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7178424 0.967 rs35123892 chr15:62303982 C/T cg00456672 chr15:62358751 C2CD4A -0.39 -8.78 -0.33 1.52e-17 Height; BRCA cis rs1577917 1.000 rs12201741 chr6:86602619 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.89 -0.43 1.43e-29 Response to antipsychotic treatment; BRCA cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg08999081 chr20:33150536 PIGU -0.34 -8.69 -0.33 2.93e-17 Glomerular filtration rate (creatinine); BRCA cis rs936229 0.656 rs2290572 chr15:75130573 A/G cg10253484 chr15:75165896 SCAMP2 -0.48 -9.65 -0.36 1.12e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg24642439 chr20:33292090 TP53INP2 -0.55 -11.83 -0.42 2.57e-29 Glomerular filtration rate (creatinine); BRCA cis rs72781680 0.898 rs56179550 chr2:23934867 C/T cg20701182 chr2:24300061 SF3B14 0.62 8.86 0.33 8.1e-18 Lymphocyte counts; BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg11062466 chr8:58055876 NA 0.44 8.53 0.32 1.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs7582180 0.606 rs4851299 chr2:100954191 C/A cg14675211 chr2:100938903 LONRF2 0.52 11.67 0.42 1.21e-28 Intelligence (multi-trait analysis); BRCA cis rs13394619 0.935 rs12468019 chr2:11725049 T/C cg07314298 chr2:11723111 GREB1 -0.53 -11.94 -0.43 7.96e-30 Endometriosis; BRCA cis rs7301826 0.627 rs1077317 chr12:131314977 C/T cg11011512 chr12:131303247 STX2 0.52 13.68 0.48 1.44e-37 Plasma plasminogen activator levels; BRCA cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg18230493 chr5:56204884 C5orf35 0.91 17.71 0.57 2.24e-57 Initial pursuit acceleration; BRCA cis rs2303759 0.709 rs10414921 chr19:49823047 C/T cg24324837 chr19:49891574 CCDC155 0.47 7.94 0.3 9.35e-15 Multiple sclerosis; BRCA cis rs6912958 0.514 rs1980792 chr6:87889917 A/G cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -8.62 -0.32 5.25e-17 Monocyte percentage of white cells; BRCA cis rs34779708 0.966 rs6481941 chr10:35440141 G/A cg03585969 chr10:35415529 CREM 0.45 9.43 0.35 7.65e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs73001065 1.000 rs56255430 chr19:19477877 A/C cg03709012 chr19:19516395 GATAD2A 0.91 9.47 0.35 5.16e-20 LDL cholesterol; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg12016809 chr21:47604291 C21orf56 -0.4 -8.1 -0.31 2.73e-15 Testicular germ cell tumor; BRCA cis rs10191773 0.535 rs11123133 chr2:112965023 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.59 8.01 0.3 5.54e-15 Yeast infection; BRCA cis rs877282 0.947 rs7475589 chr10:767479 C/G cg17470449 chr10:769945 NA 0.49 8.5 0.32 1.37e-16 Uric acid levels; BRCA cis rs870825 0.860 rs61165411 chr4:185604461 G/A cg04058563 chr4:185651563 MLF1IP 0.82 13.8 0.48 4.24e-38 Blood protein levels; BRCA cis rs877282 0.583 rs10904562 chr10:819058 T/C cg15764593 chr10:829463 NA -0.63 -10.16 -0.37 1.35e-22 Uric acid levels; BRCA cis rs2197308 0.667 rs11181073 chr12:37898543 A/G cg26384229 chr12:38710491 ALG10B 0.67 15.15 0.51 1.56e-44 Morning vs. evening chronotype; BRCA cis rs514406 0.505 rs269287 chr1:53168842 T/C cg16325326 chr1:53192061 ZYG11B 0.86 25.24 0.71 4.71e-98 Monocyte count; BRCA cis rs4766646 0.640 rs10850891 chr12:110299223 G/A cg01252219 chr12:110302105 GLTP 0.35 7.85 0.3 1.7e-14 Metabolite levels (MHPG); BRCA cis rs10751667 0.666 rs7394958 chr11:965944 C/G cg10932868 chr11:921992 NA 0.49 12.38 0.44 1.09e-31 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.8 0.39 4.23e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.86 0.3 1.62e-14 Total cholesterol levels; BRCA cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg22875332 chr1:76189707 ACADM -0.52 -10.14 -0.37 1.6400000000000001e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12711979 0.765 rs10208316 chr2:3827630 T/C cg17052675 chr2:3827356 NA -0.49 -14.28 -0.49 2.35e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs758324 0.947 rs10478989 chr5:131116055 A/G cg06307176 chr5:131281290 NA 0.53 10.26 0.38 5.85e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg08601574 chr20:25228251 PYGB -0.34 -8.18 -0.31 1.53e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7927592 0.763 rs624003 chr11:68231240 C/T cg01657329 chr11:68192670 LRP5 -0.34 -7.82 -0.3 2.18e-14 Total body bone mineral density; BRCA cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg08999081 chr20:33150536 PIGU -0.46 -12.64 -0.45 7.32e-33 Glomerular filtration rate (creatinine); BRCA cis rs2387326 0.629 rs12261739 chr10:129945520 A/G cg16087940 chr10:129947807 NA -0.46 -8.17 -0.31 1.69e-15 Select biomarker traits; BRCA cis rs35123781 1.000 rs585101 chr5:139058454 T/C cg05227215 chr5:139057496 CXXC5 0.33 8.1 0.31 2.74e-15 Schizophrenia; BRCA cis rs4664304 0.620 rs2357691 chr2:160725139 A/G cg18514922 chr2:160761262 LY75 -0.34 -7.87 -0.3 1.47e-14 Crohn's disease;Inflammatory bowel disease; BRCA trans rs11098499 0.954 rs3733524 chr4:120423729 T/C cg25517755 chr10:38738941 LOC399744 -0.4 -7.91 -0.3 1.1e-14 Corneal astigmatism; BRCA cis rs826838 0.834 rs2387842 chr12:38736442 T/C cg13010199 chr12:38710504 ALG10B 0.57 12.53 0.44 2.36e-32 Heart rate; BRCA cis rs4965272 1.000 rs2418487 chr15:100585610 T/G cg27344315 chr15:100560801 ADAMTS17 -0.38 -8.0 -0.3 5.74e-15 Gastroesophageal reflux disease; BRCA trans rs9467711 0.606 rs13190739 chr6:26587373 G/T cg01620082 chr3:125678407 NA -0.71 -8.8 -0.33 1.28e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs1153858 0.887 rs7164139 chr15:45670851 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.51 0.41 5.2e-28 Homoarginine levels; BRCA cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg04414720 chr1:150670196 GOLPH3L 0.37 8.42 0.32 2.43e-16 Tonsillectomy; BRCA cis rs6570726 0.846 rs6899900 chr6:145883873 T/G cg23711669 chr6:146136114 FBXO30 0.71 17.0 0.56 9.9e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs7737355 1.000 rs30736 chr5:130724240 A/G cg06307176 chr5:131281290 NA -0.47 -9.17 -0.34 6.18e-19 Life satisfaction; BRCA cis rs7246657 0.943 rs1015849 chr19:37946180 G/A cg23950597 chr19:37808831 NA -0.74 -13.05 -0.46 1.07e-34 Coronary artery calcification; BRCA cis rs887829 0.570 rs6753569 chr2:234595817 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.28 -0.31 7e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg08975724 chr8:8085496 FLJ10661 -0.46 -9.84 -0.36 2.35e-21 Mood instability; BRCA cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg03146154 chr1:46216737 IPP 0.45 10.04 0.37 4.15e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9467773 0.620 rs2494696 chr6:26620894 A/G cg11502198 chr6:26597334 ABT1 0.57 12.08 0.43 2.03e-30 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.909 rs35165976 chr4:120325630 G/A cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg20007245 chr22:24372913 LOC391322 -0.53 -11.97 -0.43 6.09e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 19.4 0.61 2.8e-66 Platelet count; BRCA cis rs9790314 0.663 rs778657 chr3:160719577 C/A cg03342759 chr3:160939853 NMD3 -0.44 -9.07 -0.34 1.39e-18 Morning vs. evening chronotype; BRCA cis rs7086627 0.515 rs10887894 chr10:82209952 A/G cg01528321 chr10:82214614 TSPAN14 0.62 14.12 0.49 1.3e-39 Post bronchodilator FEV1; BRCA cis rs4319547 0.737 rs10846921 chr12:122943376 G/T cg23029597 chr12:123009494 RSRC2 0.44 8.92 0.33 5.03e-18 Body mass index; BRCA cis rs1348850 0.526 rs1345138 chr2:178387100 A/T cg27490568 chr2:178487706 NA 0.51 8.57 0.32 7.54e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11711311 1.000 rs9811353 chr3:113483979 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.77 -0.36 4.24e-21 IgG glycosylation; BRCA cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg14983838 chr19:29218262 NA 0.53 10.07 0.37 3.02e-22 Methadone dose in opioid dependence; BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg11814155 chr7:99998594 ZCWPW1 0.48 8.7 0.33 2.76e-17 Platelet count; BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26314531 chr2:26401878 FAM59B -0.57 -10.19 -0.37 1.06e-22 Gut microbiome composition (summer); BRCA trans rs4650994 0.544 rs6675811 chr1:178499068 T/A cg05059571 chr16:84539110 KIAA1609 -0.49 -11.09 -0.4 2.87e-26 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7647973 0.626 rs7637711 chr3:49829653 A/G cg03060546 chr3:49711283 APEH -0.57 -10.03 -0.37 4.32e-22 Menarche (age at onset); BRCA cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg11271282 chr2:238384023 NA 0.45 8.23 0.31 1.09e-15 Prostate cancer; BRCA trans rs853679 0.546 rs2232429 chr6:28359632 T/G cg01620082 chr3:125678407 NA -0.97 -11.01 -0.4 6.21e-26 Depression; BRCA cis rs7560272 0.501 rs12713789 chr2:73945600 A/G cg20560298 chr2:73613845 ALMS1 0.33 8.4 0.32 2.84e-16 Schizophrenia; BRCA cis rs925228 0.504 rs7568176 chr2:24313758 T/A cg01493198 chr2:24299560 SF3B14 0.63 9.97 0.37 7.22e-22 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs4566357 0.595 rs6707159 chr2:227909339 T/A cg05526886 chr2:227700861 RHBDD1 -0.38 -7.83 -0.3 2.08e-14 Coronary artery disease; BRCA cis rs6028335 0.610 rs67882716 chr20:37573239 T/C cg16355469 chr20:37678765 NA 0.45 8.17 0.31 1.66e-15 Alcohol and nicotine co-dependence; BRCA cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg18305652 chr10:134549665 INPP5A 0.48 11.83 0.42 2.39e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9473147 0.516 rs7767350 chr6:47485126 C/T cg12968598 chr6:47444699 CD2AP 0.46 9.83 0.36 2.47e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs9462027 0.628 rs2764211 chr6:34704613 C/T cg07306190 chr6:34760872 UHRF1BP1 0.26 7.85 0.3 1.71e-14 Systemic lupus erythematosus; BRCA cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg23711669 chr6:146136114 FBXO30 0.75 18.35 0.59 9.94e-61 Lobe attachment (rater-scored or self-reported); BRCA trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg15556689 chr8:8085844 FLJ10661 -0.4 -11.3 -0.41 3.97e-27 Systolic blood pressure; BRCA cis rs9467711 0.591 rs10484433 chr6:26030492 G/T cg08501292 chr6:25962987 TRIM38 0.6 8.36 0.31 3.93e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs12681287 0.604 rs41469550 chr8:87406544 G/T cg27223183 chr8:87520930 FAM82B 0.43 8.43 0.32 2.36e-16 Caudate activity during reward; BRCA cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg24060327 chr5:131705240 SLC22A5 -0.63 -12.24 -0.44 4.25e-31 Breast cancer; BRCA cis rs4901869 0.902 rs10149194 chr14:59308198 A/G cg02291164 chr14:59296302 NA -0.32 -8.84 -0.33 9.6e-18 Panic disorder; BRCA cis rs66887589 0.870 rs2389875 chr4:120557014 G/T cg09307838 chr4:120376055 NA -0.46 -9.55 -0.35 2.64e-20 Diastolic blood pressure; BRCA cis rs6594713 0.643 rs10077431 chr5:112927686 A/C cg12552261 chr5:112820674 MCC -0.49 -8.27 -0.31 7.73e-16 Brain cytoarchitecture; BRCA cis rs9463078 0.753 rs3778507 chr6:44896803 G/A cg25276700 chr6:44698697 NA -0.37 -8.56 -0.32 8.23e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6496044 0.568 rs6496039 chr15:86061963 A/T cg10818794 chr15:86012489 AKAP13 -0.28 -7.83 -0.3 2.03e-14 Interstitial lung disease; BRCA cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg08614441 chr13:113633676 MCF2L -0.36 -8.41 -0.32 2.68e-16 Systolic blood pressure; BRCA cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg08885076 chr2:99613938 TSGA10 -0.45 -10.36 -0.38 2.3e-23 Chronic sinus infection; BRCA cis rs9318086 0.712 rs12875437 chr13:24453956 A/G cg25267304 chr13:24462978 PCOTH;MIPEP 0.3 8.63 0.32 5.03e-17 Myopia (pathological); BRCA cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs7131987 0.650 rs7954871 chr12:29459732 G/A cg09582351 chr12:29534625 ERGIC2 -0.43 -9.93 -0.37 1.07e-21 QT interval; BRCA cis rs1298908 0.639 rs2994388 chr10:82034262 A/G cg01528321 chr10:82214614 TSPAN14 -0.47 -10.13 -0.37 1.8e-22 Diabetic kidney disease; BRCA cis rs9790314 0.715 rs7622047 chr3:160770505 G/A cg03342759 chr3:160939853 NMD3 -0.51 -9.79 -0.36 3.62e-21 Morning vs. evening chronotype; BRCA cis rs13064411 0.735 rs722392 chr3:113228294 A/G cg18753928 chr3:113234510 CCDC52 -0.58 -12.17 -0.43 8.82e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs72928364 0.929 rs35850913 chr3:100775080 T/A cg10123952 chr3:100791384 NA 0.58 8.47 0.32 1.63e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs4242434 0.672 rs2404654 chr8:22484949 T/C cg03733263 chr8:22462867 KIAA1967 0.78 18.09 0.58 2.18e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs614226 0.935 rs17431717 chr12:120912210 G/A cg01236616 chr12:121019343 POP5 -1.17 -22.55 -0.67 2.65e-83 Type 1 diabetes nephropathy; BRCA cis rs3099143 1.000 rs3102709 chr15:77072260 C/T cg21673338 chr15:77095150 SCAPER -0.54 -9.77 -0.36 4.18e-21 Recalcitrant atopic dermatitis; BRCA cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.07 0.37 3.06e-22 Bipolar disorder; BRCA cis rs7412746 0.658 rs6660845 chr1:150841066 G/A cg15448220 chr1:150897856 SETDB1 0.35 7.81 0.3 2.42e-14 Melanoma; BRCA cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg24692254 chr21:30365293 RNF160 -0.46 -10.16 -0.37 1.42e-22 Dental caries; BRCA cis rs11105298 0.891 rs12369685 chr12:89928905 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.29 -0.34 2.45e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg04775059 chr7:64541387 NA 0.44 8.16 0.31 1.81e-15 Calcium levels; BRCA cis rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05901451 chr6:126070800 HEY2 0.39 9.6 0.36 1.76e-20 Endometrial cancer; BRCA cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg19628046 chr18:33552617 C18orf21 0.56 10.97 0.4 8.71e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9287719 0.967 rs4669598 chr2:10757838 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.99 -0.3 6.39e-15 Prostate cancer; BRCA cis rs2625529 0.824 rs12592364 chr15:72284647 C/A cg16672083 chr15:72433130 SENP8 -0.85 -17.53 -0.57 1.86e-56 Red blood cell count; BRCA cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg13736514 chr6:26305472 NA -0.46 -14.82 -0.51 6.38e-43 Educational attainment; BRCA cis rs2153535 0.541 rs6938688 chr6:8521629 G/T cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.68e-24 Motion sickness; BRCA cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.8 0.51 7.93e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg11814155 chr7:99998594 ZCWPW1 0.49 8.74 0.33 2.1e-17 Platelet count; BRCA cis rs1401999 1.000 rs6443927 chr3:183718864 A/G cg01324343 chr3:183735012 ABCC5 0.84 21.29 0.64 2.1e-76 Anterior chamber depth; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg03188948 chr7:1209495 NA 0.45 8.31 0.31 5.57e-16 Longevity;Endometriosis; BRCA cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.71 0.39 1.01e-24 Cognitive ability; BRCA cis rs2882667 0.628 rs13171173 chr5:138042464 A/C cg04439458 chr5:138467593 SIL1 0.32 7.82 0.3 2.13e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs208520 0.954 rs72884027 chr6:66995044 T/G cg07460842 chr6:66804631 NA 0.88 14.14 0.49 1.11e-39 Exhaled nitric oxide output; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg00166722 chr3:10149974 C3orf24 0.66 13.26 0.46 1.33e-35 Alzheimer's disease; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.78 -0.53 1.24e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9341808 0.727 rs9352809 chr6:80999316 C/T cg08355045 chr6:80787529 NA 0.36 9.14 0.34 8.08e-19 Sitting height ratio; BRCA cis rs7086627 0.515 rs1870147 chr10:82212541 A/T cg01528321 chr10:82214614 TSPAN14 0.62 14.02 0.49 3.76e-39 Post bronchodilator FEV1; BRCA cis rs7149337 0.805 rs3007164 chr14:51646935 A/G cg23942311 chr14:51606299 NA 0.42 12.02 0.43 3.77e-30 Cancer; BRCA cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11890956 chr21:40555474 PSMG1 1.04 29.3 0.76 2.92e-120 Cognitive function; BRCA cis rs7520050 0.966 rs10789481 chr1:46383583 C/G cg24296786 chr1:45957014 TESK2 0.43 9.59 0.35 1.97e-20 Red blood cell count;Reticulocyte count; BRCA cis rs10129255 0.500 rs2105989 chr14:107138216 C/T cg07958169 chr14:107095056 NA -0.43 -9.06 -0.34 1.6e-18 Kawasaki disease; BRCA cis rs6964587 1.000 rs6946356 chr7:91727385 G/A cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.69e-31 Breast cancer; BRCA cis rs7092929 0.883 rs835960 chr10:3586532 G/C cg14308648 chr10:3568949 NA 0.44 8.01 0.3 5.47e-15 Coronary artery calcification; BRCA cis rs2230307 0.518 rs12046458 chr1:100703069 C/T cg24955406 chr1:100503596 HIAT1 -0.46 -8.29 -0.31 6.9e-16 Carotid intima media thickness; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg09033563 chr22:24373618 LOC391322 0.58 12.64 0.45 7.68e-33 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg15839431 chr19:19639596 YJEFN3 -0.38 -8.47 -0.32 1.67e-16 Bipolar disorder; BRCA cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg16386425 chr10:429943 DIP2C -0.42 -8.96 -0.33 3.59e-18 Psychosis in Alzheimer's disease; BRCA cis rs7086627 0.515 rs6585994 chr10:82191643 A/G cg01528321 chr10:82214614 TSPAN14 0.6 12.94 0.46 3.36e-34 Post bronchodilator FEV1; BRCA cis rs6545883 0.894 rs4672436 chr2:61603357 A/C cg15711740 chr2:61764176 XPO1 0.5 12.18 0.43 8.05e-31 Tuberculosis; BRCA cis rs9790314 0.747 rs9848239 chr3:160823488 A/C cg04691961 chr3:161091175 C3orf57 -0.45 -9.77 -0.36 4.03e-21 Morning vs. evening chronotype; BRCA cis rs7572733 0.534 rs11899188 chr2:198740121 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.22 0.37 8.34e-23 Dermatomyositis; BRCA trans rs8073060 0.660 rs34184070 chr17:34003810 A/G cg19694781 chr19:47549865 TMEM160 -1.03 -21.11 -0.64 1.9e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs12188164 0.543 rs2672757 chr5:454732 A/G cg26850624 chr5:429559 AHRR 0.33 7.89 0.3 1.29e-14 Cystic fibrosis severity; BRCA cis rs838147 0.507 rs1704773 chr19:49209566 A/G cg07051648 chr19:49177693 NTN5;SEC1 -0.42 -8.02 -0.3 5.01e-15 Dietary macronutrient intake; BRCA cis rs7618915 0.547 rs11719685 chr3:52676065 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -11.96 -0.43 6.91e-30 Bipolar disorder; BRCA cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg18132916 chr6:79620363 NA -0.48 -10.76 -0.39 6.37e-25 Intelligence (multi-trait analysis); BRCA cis rs4803468 1.000 rs2241706 chr19:41912807 A/G cg09537434 chr19:41945824 ATP5SL -0.99 -23.66 -0.68 2.33e-89 Height; BRCA cis rs7020830 0.894 rs28766572 chr9:37093872 G/T cg14294708 chr9:37120828 ZCCHC7 1.09 33.89 0.8 7.43e-145 Schizophrenia; BRCA cis rs1153858 1.000 rs10444821 chr15:45647236 C/T cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA trans rs35110281 0.744 rs162373 chr21:44927107 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.37 -7.84 -0.3 1.83e-14 Mean corpuscular volume; BRCA cis rs3806843 0.900 rs3756334 chr5:140213796 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.78 -0.36 3.93e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs10193935 0.901 rs12620021 chr2:42477034 T/C cg27598129 chr2:42591480 NA -0.98 -15.05 -0.51 5.11e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg02733842 chr7:1102375 C7orf50 -0.63 -11.93 -0.43 9e-30 Bronchopulmonary dysplasia; BRCA cis rs2737618 0.674 rs2249150 chr1:200083654 G/A cg21825944 chr1:200113062 NR5A2 -0.39 -9.07 -0.34 1.4e-18 Uric acid levels; BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -8.17 -0.31 1.7e-15 Bipolar disorder and schizophrenia; BRCA cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.53 10.71 0.39 9.83e-25 Personality dimensions; BRCA trans rs6952808 1.000 rs4719319 chr7:1888094 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 8.22 0.31 1.11e-15 Bipolar disorder and schizophrenia; BRCA cis rs701145 0.585 rs436852 chr3:153913403 G/A cg17054900 chr3:154042577 DHX36 0.51 8.93 0.33 4.54e-18 Coronary artery disease; BRCA cis rs7575217 0.697 rs796067 chr2:101707009 C/T cg23907051 chr2:101730305 TBC1D8 -0.2 -7.93 -0.3 9.72e-15 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.09 0.37 2.61e-22 Calcium levels; BRCA trans rs11098499 0.619 rs28502463 chr4:120257023 T/C cg25214090 chr10:38739885 LOC399744 0.47 10.8 0.39 4.5e-25 Corneal astigmatism; BRCA cis rs757081 0.608 rs214938 chr11:17188516 C/T cg15432903 chr11:17409602 KCNJ11 -0.45 -8.51 -0.32 1.25e-16 Systolic blood pressure; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg11814155 chr7:99998594 ZCWPW1 0.5 8.63 0.32 4.74e-17 Platelet count; BRCA cis rs7520050 0.966 rs7524495 chr1:46266932 T/C cg24296786 chr1:45957014 TESK2 0.44 9.96 0.37 8.03e-22 Red blood cell count;Reticulocyte count; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg24642844 chr7:1081250 C7orf50 -0.87 -15.93 -0.53 2.34e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg18404041 chr3:52824283 ITIH1 -0.52 -16.79 -0.55 1.16e-52 Bipolar disorder; BRCA trans rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.37 -8.27 -0.31 7.59e-16 Endometrial cancer; BRCA cis rs2777491 0.957 rs8027626 chr15:41711514 T/G cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.24 -0.54 6.98e-50 Ulcerative colitis; BRCA trans rs61931739 0.500 rs10844734 chr12:34043083 G/A cg13010199 chr12:38710504 ALG10B 0.4 8.09 0.3 3.05e-15 Morning vs. evening chronotype; BRCA cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.55 -0.35 2.76e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.82 -0.39 3.62e-25 Mean corpuscular volume; BRCA cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg08048268 chr3:133502702 NA -0.34 -8.4 -0.32 2.92e-16 Iron status biomarkers; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26314531 chr2:26401878 FAM59B 0.75 10.51 0.38 6.22e-24 Gut microbiome composition (summer); BRCA cis rs4409675 0.576 rs6662916 chr1:28219873 G/T cg23691781 chr1:28212827 C1orf38 0.33 11.14 0.4 1.88e-26 Corneal astigmatism; BRCA cis rs7011049 1.000 rs72643583 chr8:53847269 C/G cg26025543 chr8:53854495 NA 0.55 9.57 0.35 2.31e-20 Systolic blood pressure; BRCA trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg27661571 chr11:113659931 NA -0.7 -10.89 -0.4 1.93e-25 Hip circumference adjusted for BMI; BRCA cis rs6582630 0.599 rs4882313 chr12:38454011 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.89 -0.36 1.53e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs4812048 0.649 rs6070706 chr20:57628239 C/T cg14073986 chr20:57617431 SLMO2 0.75 10.75 0.39 6.71e-25 Mean platelet volume; BRCA cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg18876405 chr7:65276391 NA 0.71 18.63 0.59 3.25e-62 Aortic root size; BRCA trans rs11098499 0.866 rs12510451 chr4:120289143 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs2279817 0.743 rs12023874 chr1:18025612 A/G cg21791023 chr1:18019539 ARHGEF10L 0.51 15.94 0.53 2.01e-48 Neuroticism; BRCA cis rs11984145 1.000 rs11970960 chr7:38883838 A/G cg19327137 chr7:38886074 VPS41 0.5 8.81 0.33 1.19e-17 Cognitive performance; BRCA cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg20607287 chr7:12443886 VWDE -0.58 -8.24 -0.31 9.69e-16 Coronary artery disease; BRCA cis rs7617773 0.817 rs3729577 chr3:48228994 A/C cg11946769 chr3:48343235 NME6 0.68 13.78 0.48 5.29e-38 Coronary artery disease; BRCA cis rs9649465 1.000 rs3958047 chr7:123327936 G/C cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs61990749 0.597 rs3783980 chr14:78219807 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.82 0.36 2.75e-21 Fibroblast growth factor basic levels; BRCA cis rs10911251 0.528 rs6669199 chr1:183082421 C/A ch.1.3577855R chr1:183094577 LAMC1 0.68 18.01 0.58 5.98e-59 Colorectal cancer; BRCA cis rs11997175 0.740 rs4733462 chr8:33679904 A/G ch.8.33884649F chr8:33765107 NA 0.35 8.18 0.31 1.49e-15 Body mass index; BRCA cis rs1878931 0.597 rs37816 chr16:3456371 G/A cg02880119 chr16:3481970 NA 0.51 9.3 0.35 2.29e-19 Body mass index (adult); BRCA cis rs72781680 0.821 rs1022346 chr2:24127849 T/C cg08917208 chr2:24149416 ATAD2B 0.62 10.54 0.38 4.72e-24 Lymphocyte counts; BRCA cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg02475777 chr4:1388615 CRIPAK 0.42 9.62 0.36 1.49e-20 Longevity; BRCA cis rs67460515 0.563 rs1599375 chr3:160897771 C/T cg03342759 chr3:160939853 NMD3 0.72 14.88 0.51 3.21e-43 Parkinson's disease; BRCA trans rs11098499 0.863 rs13134665 chr4:120426430 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.13 0.31 2.28e-15 Corneal astigmatism; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7577696 0.568 rs462878 chr2:32438655 A/G cg02381751 chr2:32503542 YIPF4 0.47 8.58 0.32 7.11e-17 Inflammatory biomarkers; BRCA cis rs589448 0.902 rs315124 chr12:69771727 G/A cg22834771 chr12:69754056 YEATS4 -0.4 -10.04 -0.37 3.89e-22 Cerebrospinal fluid biomarker levels; BRCA cis rs6546550 0.935 rs4241261 chr2:70063660 A/G cg02498382 chr2:70120550 SNRNP27 -0.5 -10.55 -0.39 4.24e-24 Prevalent atrial fibrillation; BRCA cis rs6570726 0.516 rs9322025 chr6:145729196 C/T cg23711669 chr6:146136114 FBXO30 0.47 9.8 0.36 3.31e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.8e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6752107 1.000 rs34123137 chr2:234167881 T/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.31 0.41 3.69e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg08514558 chr10:81106712 PPIF 0.37 8.5 0.32 1.39e-16 Height; BRCA cis rs7131987 0.934 rs2216854 chr12:29423460 G/A cg09582351 chr12:29534625 ERGIC2 -0.39 -9.42 -0.35 7.97e-20 QT interval; BRCA cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06022373 chr22:39101656 GTPBP1 0.7 15.83 0.53 7.43e-48 Menopause (age at onset); BRCA cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg18876405 chr7:65276391 NA -0.5 -11.15 -0.4 1.6e-26 Aortic root size; BRCA cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11644478 chr21:40555479 PSMG1 -0.51 -10.9 -0.4 1.75e-25 Menarche (age at onset); BRCA cis rs10499694 0.933 rs11575356 chr7:50594821 T/C cg18232548 chr7:50535776 DDC -0.39 -9.42 -0.35 7.95e-20 Body mass index; BRCA cis rs61931739 0.500 rs6488215 chr12:34434803 A/T cg06521331 chr12:34319734 NA -0.52 -10.21 -0.37 9.32e-23 Morning vs. evening chronotype; BRCA cis rs9649465 0.807 rs11770249 chr7:123286412 T/C cg04330084 chr7:123175371 IQUB -0.31 -8.55 -0.32 8.77e-17 Migraine; BRCA cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.57 -0.45 1.56e-32 Bipolar disorder; BRCA cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg17420585 chr12:42539391 GXYLT1 -0.49 -10.42 -0.38 1.36e-23 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg26031613 chr14:104095156 KLC1 -0.53 -9.52 -0.35 3.5e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg21770322 chr7:97807741 LMTK2 0.41 10.87 0.4 2.17e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg21770322 chr7:97807741 LMTK2 0.42 11.14 0.4 1.85e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg06484146 chr7:12443880 VWDE -0.61 -10.32 -0.38 3.37e-23 Coronary artery disease; BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg24549020 chr5:56110836 MAP3K1 0.65 13.12 0.46 5.57e-35 Type 2 diabetes; BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.1 0.31 2.81e-15 Tonsillectomy; BRCA cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg21518248 chr2:162101506 NA 0.71 17.56 0.57 1.35e-56 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs17539620 0.624 rs871068 chr6:154837514 C/A cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.68 -0.39 1.29e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6580649 0.771 rs1635535 chr12:48386241 A/G cg05342945 chr12:48394962 COL2A1 -0.48 -9.46 -0.35 5.59e-20 Lung cancer; BRCA cis rs17490626 0.568 rs12416520 chr10:71211945 A/G cg12610070 chr10:71211762 TSPAN15 -0.34 -11.96 -0.43 6.75e-30 Thrombosis; BRCA cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg13319975 chr6:146136371 FBXO30 -0.34 -7.89 -0.3 1.3e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg05340658 chr4:99064831 C4orf37 0.68 17.05 0.56 5.48e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg14983838 chr19:29218262 NA 0.55 9.36 0.35 1.32e-19 Methadone dose in opioid dependence; BRCA cis rs7945718 0.967 rs11022496 chr11:12789561 G/A cg25843174 chr11:12811716 TEAD1 0.24 9.24 0.34 3.65e-19 Educational attainment (years of education); BRCA cis rs921968 0.541 rs6720403 chr2:219294258 A/C cg02176678 chr2:219576539 TTLL4 -0.45 -11.81 -0.42 2.89e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs7246657 0.882 rs4803539 chr19:37897522 A/C cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.7e-28 Coronary artery calcification; BRCA cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg06636001 chr8:8085503 FLJ10661 -0.49 -8.64 -0.32 4.45e-17 Obesity-related traits; BRCA cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.862 rs1167408 chr7:65556108 G/A cg18876405 chr7:65276391 NA -0.52 -11.7 -0.42 8.87e-29 Aortic root size; BRCA cis rs7523273 0.565 rs11118451 chr1:207887493 A/G cg22525895 chr1:207977042 MIR29B2 0.33 7.87 0.3 1.56e-14 Schizophrenia; BRCA cis rs6740322 0.748 rs6727631 chr2:43470408 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -12.8 -0.45 1.52e-33 Coronary artery disease; BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 17.2 0.56 9.22e-55 Platelet count; BRCA cis rs16958440 0.708 rs62096465 chr18:44629624 C/T cg17192377 chr18:44677553 HDHD2 0.48 8.0 0.3 5.82e-15 Sitting height ratio; BRCA cis rs9814567 1.000 rs9864439 chr3:134298671 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.02 -0.34 2.21e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504073 0.647 rs62507252 chr8:50028795 C/G cg00325661 chr8:49890786 NA 0.47 12.85 0.45 9.3e-34 Blood metabolite ratios; BRCA cis rs7582180 0.614 rs1030901 chr2:101007314 G/A cg14675211 chr2:100938903 LONRF2 0.42 9.62 0.36 1.44e-20 Intelligence (multi-trait analysis); BRCA cis rs11608355 0.515 rs1045263 chr12:109974191 A/G cg05360138 chr12:110035743 NA 0.73 13.3 0.47 8.17e-36 Neuroticism; BRCA cis rs35740288 0.580 rs34526042 chr15:86339956 C/T cg20737812 chr15:86336631 KLHL25 -0.39 -9.39 -0.35 1e-19 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg22307029 chr19:49891270 CCDC155 0.53 9.07 0.34 1.42e-18 Multiple sclerosis; BRCA cis rs56104184 0.775 rs55737338 chr19:49403141 A/G cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg14036092 chr11:66035641 RAB1B 0.4 11.02 0.4 5.49e-26 Gout; BRCA cis rs9309711 0.961 rs11692184 chr2:3480710 C/T cg10845886 chr2:3471009 TTC15 -0.75 -16.36 -0.54 1.72e-50 Neurofibrillary tangles; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg12444411 chr7:2802554 GNA12 -0.32 -8.13 -0.31 2.19e-15 Height; BRCA trans rs9325144 0.560 rs7980635 chr12:38668355 G/T cg23762105 chr12:34175262 ALG10 0.34 7.96 0.3 7.76e-15 Morning vs. evening chronotype; BRCA cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg01849466 chr14:104193079 ZFYVE21 -0.47 -10.49 -0.38 7.35e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs7727544 0.735 rs273914 chr5:131660431 A/T cg24060327 chr5:131705240 SLC22A5 -0.48 -10.17 -0.37 1.28e-22 Blood metabolite levels; BRCA cis rs1048238 0.545 rs848199 chr1:16292742 C/T cg21385522 chr1:16154831 NA -0.47 -9.94 -0.37 9.68e-22 Systolic blood pressure; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg24642844 chr7:1081250 C7orf50 -0.91 -16.39 -0.54 1.21e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs950776 0.616 rs12901300 chr15:78892952 G/A cg06917634 chr15:78832804 PSMA4 0.57 12.31 0.44 2.22e-31 Sudden cardiac arrest; BRCA cis rs877282 0.891 rs34383514 chr10:800181 T/C cg17470449 chr10:769945 NA 0.49 8.41 0.32 2.62e-16 Uric acid levels; BRCA cis rs3008870 0.701 rs2815367 chr1:67500762 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.62 13.51 0.47 8.88e-37 Lymphocyte percentage of white cells; BRCA trans rs1994135 0.654 rs1447872 chr12:33718343 C/A cg26384229 chr12:38710491 ALG10B 0.61 11.94 0.43 8.11e-30 Resting heart rate; BRCA cis rs11190604 0.767 rs10883490 chr10:102194775 C/T cg07080220 chr10:102295463 HIF1AN 0.5 10.25 0.38 6.26e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg23978390 chr7:1156363 C7orf50 -0.4 -8.17 -0.31 1.66e-15 Bronchopulmonary dysplasia; BRCA trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21659725 chr3:3221576 CRBN -0.49 -12.46 -0.44 4.49e-32 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.78 0.36 3.87e-21 Menopause (age at onset); BRCA cis rs4803468 0.901 rs3745292 chr19:41888506 A/G cg09537434 chr19:41945824 ATP5SL -0.96 -22.64 -0.67 9.45e-84 Height; BRCA cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg18016565 chr1:150552671 MCL1 0.34 7.98 0.3 6.95e-15 Tonsillectomy; BRCA cis rs4988958 0.565 rs885088 chr2:103039044 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.34 0.31 4.74e-16 Asthma (childhood onset); BRCA trans rs9325144 0.600 rs10785621 chr12:38744912 C/T cg23762105 chr12:34175262 ALG10 -0.37 -9.47 -0.35 5.23e-20 Morning vs. evening chronotype; BRCA cis rs7918232 0.941 rs10829195 chr10:27431564 G/A cg14442939 chr10:27389572 ANKRD26 0.66 10.92 0.4 1.5e-25 Breast cancer; BRCA cis rs7572733 0.576 rs4850441 chr2:198913413 A/G cg00792783 chr2:198669748 PLCL1 -0.4 -8.67 -0.32 3.6e-17 Dermatomyositis; BRCA cis rs68170813 0.559 rs58319984 chr7:106965794 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.95 -0.33 3.93e-18 Coronary artery disease; BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg26314531 chr2:26401878 FAM59B 0.75 12.64 0.45 7.73e-33 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg06671706 chr8:8559999 CLDN23 0.43 8.41 0.32 2.77e-16 Obesity-related traits; BRCA cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg06346307 chr22:19949965 COMT 0.31 8.85 0.33 8.71e-18 Blood metabolite levels; BRCA cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg05707623 chr12:122985044 ZCCHC8 0.45 8.8 0.33 1.23e-17 Body mass index; BRCA cis rs2236918 1.000 rs2236918 chr1:242017826 C/G cg17736920 chr1:242011382 EXO1 -0.45 -10.08 -0.37 2.82e-22 Menopause (age at onset); BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.63 10.34 0.38 2.77e-23 Renal function-related traits (BUN); BRCA cis rs9311474 0.629 rs9853056 chr3:52555957 T/C cg18404041 chr3:52824283 ITIH1 -0.29 -8.31 -0.31 5.69e-16 Electroencephalogram traits; BRCA cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.93 0.6 8.5e-64 Cognitive function; BRCA cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg02175503 chr12:58329896 NA 0.53 11.14 0.4 1.88e-26 Intelligence (multi-trait analysis); BRCA cis rs9469578 0.892 rs73743334 chr6:33714094 G/C cg18708504 chr6:33715942 IP6K3 0.7 10.18 0.37 1.12e-22 Phosphorus levels; BRCA cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg10792982 chr14:105748885 BRF1 0.47 10.96 0.4 9.68e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs10129255 0.500 rs8014529 chr14:107192302 G/A cg07958169 chr14:107095056 NA -0.41 -8.77 -0.33 1.58e-17 Kawasaki disease; BRCA trans rs11098499 0.863 rs59732491 chr4:120489588 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.35 0.31 4.21e-16 Corneal astigmatism; BRCA cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.46 -0.38 9.45e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg12000995 chr2:27665139 KRTCAP3 -0.31 -7.81 -0.3 2.35e-14 Total body bone mineral density; BRCA cis rs4722404 0.620 rs6978200 chr7:3118835 A/G cg19214707 chr7:3157722 NA -0.36 -8.12 -0.31 2.43e-15 Atopic dermatitis; BRCA trans rs2204008 0.837 rs11495722 chr12:38337245 G/A cg06521331 chr12:34319734 NA -0.52 -9.36 -0.35 1.38e-19 Bladder cancer; BRCA trans rs11098499 0.954 rs4309825 chr4:120314881 C/T cg25214090 chr10:38739885 LOC399744 -0.51 -11.64 -0.42 1.52e-28 Corneal astigmatism; BRCA cis rs751728 0.664 rs6929696 chr6:33759290 C/T cg25922239 chr6:33757077 LEMD2 -0.48 -12.06 -0.43 2.48e-30 Crohn's disease; BRCA trans rs17685 0.712 rs59659102 chr7:75710114 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 27.58 0.74 6.51e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs738322 0.554 rs6001033 chr22:38557513 T/A cg25457927 chr22:38595422 NA -0.35 -12.93 -0.46 3.76e-34 Cutaneous nevi; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs11123610 0.520 rs12711962 chr2:3717985 C/T cg19052272 chr2:3704530 ALLC -0.45 -9.95 -0.37 8.86e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2147904 0.866 rs1886729 chr1:42363966 G/A cg16685388 chr1:42384056 HIVEP3 0.31 8.78 0.33 1.46e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs2882667 0.690 rs1567313 chr5:138110702 A/G cg04439458 chr5:138467593 SIL1 0.31 7.85 0.3 1.74e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs713587 0.967 rs713586 chr2:25158008 A/G cg01884057 chr2:25150051 NA 0.31 8.15 0.31 1.85e-15 Body mass index in non-asthmatics; BRCA cis rs921968 0.565 rs7573999 chr2:219601392 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.02 -0.4 5.55e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg11833968 chr6:79620685 NA -0.43 -9.47 -0.35 5.49e-20 Intelligence (multi-trait analysis); BRCA cis rs6964587 1.000 rs11982047 chr7:91705274 G/A cg01689657 chr7:91764605 CYP51A1 0.23 8.07 0.3 3.58e-15 Breast cancer; BRCA cis rs7618915 0.571 rs33964154 chr3:52596914 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.09 0.4 3.05e-26 Bipolar disorder; BRCA cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg26769984 chr7:1090371 C7orf50 0.64 11.44 0.41 1.06e-27 Bronchopulmonary dysplasia; BRCA cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs586533 0.881 rs676553 chr11:99506436 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.13 0.31 2.3e-15 Depressive symptoms (multi-trait analysis); BRCA trans rs6598955 0.572 rs6598951 chr1:26592714 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.69 -16.43 -0.54 7.06e-51 Obesity-related traits; BRCA cis rs6598955 0.671 rs55791848 chr1:26582711 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg01939980 chr4:1354348 KIAA1530 -0.34 -8.28 -0.31 7.39e-16 Obesity-related traits; BRCA cis rs12050794 0.671 rs2052713 chr15:72520392 G/C cg16672083 chr15:72433130 SENP8 0.63 14.91 0.51 2.26e-43 Metabolite levels (HVA/MHPG ratio); BRCA cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.38 0.49 8.14e-41 Colorectal cancer; BRCA trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg06636001 chr8:8085503 FLJ10661 0.49 10.83 0.39 3.28e-25 Neuroticism; BRCA cis rs9788721 0.836 rs17483548 chr15:78730313 G/A cg18825076 chr15:78729989 IREB2 -0.44 -8.34 -0.31 4.41e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs6977660 0.714 rs12386623 chr7:19791875 A/G cg05791153 chr7:19748676 TWISTNB -0.57 -10.45 -0.38 1.1e-23 Thyroid stimulating hormone; BRCA cis rs1215050 0.765 rs181521 chr4:98745728 A/C cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg08470875 chr2:26401718 FAM59B -0.51 -8.26 -0.31 8.29e-16 Gut microbiome composition (summer); BRCA cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg17971929 chr21:40555470 PSMG1 0.79 18.48 0.59 2.14e-61 Cognitive function; BRCA cis rs7246657 0.678 rs4802024 chr19:38052193 T/C cg18154014 chr19:37997991 ZNF793 0.48 9.13 0.34 8.69e-19 Coronary artery calcification; BRCA cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA cis rs11112613 0.762 rs73184077 chr12:105949999 G/A cg03607813 chr12:105948248 NA 0.6 11.21 0.41 9.41e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg02733842 chr7:1102375 C7orf50 -0.58 -10.96 -0.4 1e-25 Bronchopulmonary dysplasia; BRCA cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.52 -7.89 -0.3 1.31e-14 Birth weight; BRCA cis rs7572733 0.534 rs4850815 chr2:198786167 G/T cg00792783 chr2:198669748 PLCL1 -0.46 -9.98 -0.37 7.05e-22 Dermatomyositis; BRCA cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg12311346 chr5:56204834 C5orf35 -0.8 -15.68 -0.53 4.12e-47 Initial pursuit acceleration; BRCA cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.69e-52 Extrinsic epigenetic age acceleration; BRCA cis rs1003719 0.788 rs2835578 chr21:38457671 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.18 0.49 7.11e-40 Eye color traits; BRCA cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.83e-54 Bladder cancer; BRCA cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.89e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.24 0.31 1e-15 Personality dimensions; BRCA cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg00071950 chr4:10020882 SLC2A9 -0.55 -13.61 -0.47 3e-37 Bone mineral density; BRCA cis rs2336384 1.000 rs1810563 chr1:12054030 A/G cg13216073 chr1:12042593 MFN2 -0.51 -10.83 -0.39 3.37e-25 Platelet count; BRCA cis rs10089 1.000 rs77086350 chr5:127494431 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 12.89 0.45 5.95e-34 Ileal carcinoids; BRCA cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg13206674 chr6:150067644 NUP43 0.45 14.12 0.49 1.32e-39 Lung cancer; BRCA cis rs3806843 1.000 rs10057161 chr5:140156831 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.77 -0.36 4.14e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs7072216 0.763 rs10736129 chr10:100171571 C/T cg26618903 chr10:100175079 PYROXD2 0.33 9.78 0.36 3.85e-21 Metabolite levels; BRCA cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs1843834 0.898 rs2014887 chr2:225520082 A/G cg22455342 chr2:225449267 CUL3 0.34 8.41 0.32 2.62e-16 IgE levels in asthmatics (D.p. specific); BRCA trans rs7615952 0.512 rs2979336 chr3:125357470 G/A cg07211511 chr3:129823064 LOC729375 -0.58 -10.66 -0.39 1.58e-24 Blood pressure (smoking interaction); BRCA cis rs965469 0.843 rs6051842 chr20:3397434 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -10.6 -0.39 2.73e-24 IFN-related cytopenia; BRCA cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg02733842 chr7:1102375 C7orf50 -0.71 -12.19 -0.43 6.91e-31 Bronchopulmonary dysplasia; BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.67 0.61 1.01e-67 Platelet count; BRCA cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs4363385 0.747 rs10399896 chr1:152975083 T/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.01 -0.34 2.4e-18 Inflammatory skin disease; BRCA cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg23711669 chr6:146136114 FBXO30 -0.79 -19.25 -0.61 1.82e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg26597838 chr10:835615 NA 0.87 15.67 0.53 4.71e-47 Eosinophil percentage of granulocytes; BRCA cis rs10851411 0.697 rs56069741 chr15:42855057 G/A cg21293051 chr15:42870591 STARD9 0.52 8.79 0.33 1.4e-17 Glucose homeostasis traits; BRCA trans rs853679 0.546 rs13214023 chr6:28332141 A/G cg06606381 chr12:133084897 FBRSL1 0.79 8.57 0.32 7.6e-17 Depression; BRCA trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg15704280 chr7:45808275 SEPT13 0.48 9.28 0.34 2.53e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg27535305 chr1:53392650 SCP2 -0.48 -11.74 -0.42 6.05e-29 Monocyte count; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.7 -14.09 -0.49 1.94e-39 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2243480 1.000 rs34702770 chr7:65344823 T/C cg18252515 chr7:66147081 NA -0.81 -11.34 -0.41 2.84e-27 Diabetic kidney disease; BRCA cis rs2559856 1.000 rs2695298 chr12:102082589 G/A cg12213457 chr12:102090980 CHPT1 -0.37 -8.03 -0.3 4.74e-15 Blood protein levels; BRCA cis rs2011503 1.000 rs8111093 chr19:19505548 C/T cg11584989 chr19:19387371 SF4 0.63 13.5 0.47 1e-36 Bipolar disorder; BRCA cis rs7267979 0.966 rs6083817 chr20:25343998 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.28 -0.34 2.52e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs926392 0.896 rs7268772 chr20:37684501 A/G cg16355469 chr20:37678765 NA 0.32 8.07 0.3 3.43e-15 Dialysis-related mortality; BRCA cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.34 0.41 2.88e-27 Electroencephalogram traits; BRCA trans rs11098499 0.863 rs6534141 chr4:120485223 A/T cg25214090 chr10:38739885 LOC399744 0.51 11.51 0.41 5.53e-28 Corneal astigmatism; BRCA cis rs8038465 0.638 rs7495543 chr15:73955133 G/C cg15420318 chr15:73925796 NPTN 0.41 9.25 0.34 3.31e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7617773 0.743 rs13081633 chr3:48357281 A/G cg11946769 chr3:48343235 NME6 0.69 13.89 0.48 1.68e-38 Coronary artery disease; BRCA cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.33 -0.35 1.77e-19 Body mass index; BRCA cis rs9486715 0.929 rs7775721 chr6:97056979 C/T cg06623918 chr6:96969491 KIAA0776 -0.88 -24.18 -0.69 3.15e-92 Headache; BRCA cis rs7246657 0.943 rs1373991 chr19:37838911 T/C cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs10733682 0.659 rs4358894 chr9:129464802 C/G cg00232160 chr9:129468157 NA 0.39 9.14 0.34 7.93e-19 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1691799 0.899 rs1168305 chr12:66738714 A/G cg16791601 chr12:66731901 HELB -0.64 -17.29 -0.56 3.01e-55 White blood cell count (basophil); BRCA cis rs4363385 0.818 rs2711 chr1:153005156 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs58785573 0.504 rs12646137 chr4:38609650 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.42 8.16 0.31 1.78e-15 Lymphocyte percentage of white cells; BRCA cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg12386194 chr3:101231763 SENP7 0.45 9.68 0.36 8.74e-21 Colorectal cancer; BRCA cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg12935359 chr14:103987150 CKB -0.58 -13.22 -0.46 1.86e-35 Intelligence (multi-trait analysis); BRCA cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.06 -0.37 3.44e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.66 0.5 3.88e-42 Colorectal cancer; BRCA cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg23711669 chr6:146136114 FBXO30 0.74 17.59 0.57 8.91e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs6546550 0.901 rs6750488 chr2:70146125 C/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.73e-28 Prevalent atrial fibrillation; BRCA cis rs708547 0.575 rs6847086 chr4:57791864 A/G cg25525207 chr4:57843836 C4orf14;POLR2B 0.41 8.01 0.3 5.48e-15 Response to bleomycin (chromatid breaks); BRCA cis rs7633770 0.786 rs6808214 chr3:46682746 T/C cg11219411 chr3:46661640 NA 0.65 16.87 0.56 4.29e-53 Coronary artery disease; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg03188948 chr7:1209495 NA 0.84 11.6 0.42 2.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg03060546 chr3:49711283 APEH -0.6 -10.38 -0.38 1.96e-23 Menarche (age at onset); BRCA cis rs7607369 0.536 rs4674344 chr2:219669875 A/T cg02176678 chr2:219576539 TTLL4 -0.38 -10.12 -0.37 1.96e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs13046373 0.508 rs1012969 chr21:31996108 G/A cg22337977 chr21:31811175 KRTAP15-1 0.34 8.16 0.31 1.81e-15 HDL cholesterol; BRCA cis rs708547 0.578 rs781665 chr4:57831461 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.52 0.35 3.39e-20 Response to bleomycin (chromatid breaks); BRCA cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg20701182 chr2:24300061 SF3B14 0.53 8.8 0.33 1.29e-17 Lymphocyte counts; BRCA cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.51 8.39 0.32 3.04e-16 Lung function (FEV1/FVC); BRCA cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg27535305 chr1:53392650 SCP2 -0.38 -9.12 -0.34 9.59e-19 Monocyte count; BRCA trans rs4596713 0.538 rs10781456 chr9:71782869 G/A cg16512924 chr15:28394682 HERC2 0.45 10.86 0.39 2.46e-25 Headache; BRCA cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg04553112 chr3:125709451 NA -0.56 -8.54 -0.32 9.87e-17 Blood pressure (smoking interaction); BRCA cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg23788917 chr6:8435910 SLC35B3 -0.48 -10.65 -0.39 1.64e-24 Motion sickness; BRCA cis rs6495367 1.000 rs4778634 chr15:79380822 C/T cg17916960 chr15:79447300 NA 0.33 8.07 0.3 3.5e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4363385 0.818 rs1890285 chr1:153015396 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.08 -0.34 1.37e-18 Inflammatory skin disease; BRCA cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg10932868 chr11:921992 NA 0.47 12.08 0.43 2.14e-30 Alzheimer's disease (late onset); BRCA cis rs6060717 0.654 rs6058347 chr20:34483781 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -11.43 -0.41 1.23e-27 Hip circumference adjusted for BMI; BRCA cis rs8114671 0.662 rs3761143 chr20:33545745 C/T cg07148914 chr20:33460835 GGT7 0.45 9.86 0.36 1.9e-21 Height; BRCA cis rs3784262 0.669 rs12905608 chr15:58314139 C/T cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.16 -0.37 1.38e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg26516362 chr5:178986906 RUFY1 0.45 12.79 0.45 1.67e-33 Lung cancer; BRCA cis rs3820928 0.874 rs10207404 chr2:227794420 T/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.85 -0.33 8.46e-18 Pulmonary function; BRCA trans rs2204008 0.577 rs2623049 chr12:38018831 G/A cg06521331 chr12:34319734 NA 0.43 8.44 0.32 2.07e-16 Bladder cancer; BRCA cis rs2249625 0.874 rs2254147 chr6:72920943 C/G cg18830697 chr6:72922368 RIMS1 -0.37 -7.9 -0.3 1.2e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg09184832 chr6:79620586 NA -0.53 -11.72 -0.42 7.35e-29 Intelligence (multi-trait analysis); BRCA cis rs4566357 0.615 rs12328876 chr2:227918899 G/T cg11843606 chr2:227700838 RHBDD1 -0.44 -9.69 -0.36 8.15e-21 Coronary artery disease; BRCA cis rs4660306 0.961 rs4660867 chr1:45986484 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.96 -0.3 8.12e-15 Homocysteine levels; BRCA cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.57 -11.69 -0.42 9.32e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs3008870 1.000 rs2985825 chr1:67412822 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.67 0.67 5.75e-84 Lymphocyte percentage of white cells; BRCA cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg23711669 chr6:146136114 FBXO30 -0.81 -20.04 -0.62 1.05e-69 Lobe attachment (rater-scored or self-reported); BRCA cis rs6960043 0.738 rs12540947 chr7:15059326 T/C cg19272540 chr7:15055459 NA 0.25 8.38 0.31 3.3e-16 Type 2 diabetes; BRCA cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg26818010 chr10:134567672 INPP5A -0.78 -15.37 -0.52 1.39e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.69 0.45 4.34e-33 Mean platelet volume; BRCA cis rs11252926 0.673 rs7096559 chr10:499188 C/T cg18196295 chr10:418757 DIP2C 0.47 10.67 0.39 1.44e-24 Psychosis in Alzheimer's disease; BRCA cis rs2243480 1.000 rs34577383 chr7:65385726 C/T cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs4302748 0.862 rs73335288 chr7:36185070 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.88 -0.3 1.4e-14 Aortic root size; BRCA cis rs2243480 0.831 rs57294491 chr7:65684901 T/A cg18252515 chr7:66147081 NA 1.06 15.63 0.53 6.79e-47 Diabetic kidney disease; BRCA cis rs561341 1.000 rs508192 chr17:30315147 C/T cg23018236 chr17:30244563 NA 0.56 9.45 0.35 6.15e-20 Hip circumference adjusted for BMI; BRCA cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg06766960 chr11:133703094 NA -0.61 -12.71 -0.45 3.76e-33 Childhood ear infection; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg10950524 chr7:2139216 MAD1L1 0.28 7.96 0.3 7.73e-15 Schizophrenia; BRCA cis rs4237845 0.788 rs6581157 chr12:58288793 C/T cg02175503 chr12:58329896 NA 0.51 10.66 0.39 1.58e-24 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg26597838 chr10:835615 NA 1.3 21.91 0.65 8.86e-80 Eosinophil percentage of granulocytes; BRCA trans rs2832077 0.943 rs2832091 chr21:30162855 C/T cg14791747 chr16:20752902 THUMPD1 0.41 9.75 0.36 4.9e-21 Cognitive test performance; BRCA cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg26818010 chr10:134567672 INPP5A -0.63 -13.61 -0.47 3.22e-37 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg13175981 chr1:150552382 MCL1 0.54 11.73 0.42 6.51e-29 Tonsillectomy; BRCA cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.07 0.4 3.59e-26 Intelligence (multi-trait analysis); BRCA cis rs921968 0.565 rs3770219 chr2:219619766 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 4.01e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg05347473 chr6:146136440 FBXO30 0.53 11.18 0.4 1.31e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs7520050 0.778 rs3014216 chr1:46035760 A/T cg24296786 chr1:45957014 TESK2 -0.43 -9.64 -0.36 1.29e-20 Red blood cell count;Reticulocyte count; BRCA cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg23711669 chr6:146136114 FBXO30 0.79 18.86 0.6 2.07e-63 Lobe attachment (rater-scored or self-reported); BRCA trans rs208515 0.525 rs12214310 chr6:66666308 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 15.87 0.53 4.53e-48 Exhaled nitric oxide levels; BRCA cis rs2652834 1.000 rs36116701 chr15:63397494 T/C cg05507819 chr15:63340323 TPM1 0.45 8.09 0.3 3.04e-15 HDL cholesterol; BRCA cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.5 0.32 1.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11733284 0.515 rs10025104 chr4:47855999 T/C cg21463140 chr4:47913142 NFXL1 -0.4 -10.8 -0.39 4.19e-25 Renal underexcretion gout;Gout; BRCA cis rs17376456 1.000 rs66978370 chr5:93553633 G/A cg25358565 chr5:93447407 FAM172A 1.17 18.34 0.59 1.17e-60 Diabetic retinopathy; BRCA cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg14844989 chr11:31128820 NA -0.43 -9.73 -0.36 5.79e-21 Red blood cell count; BRCA cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg15839431 chr19:19639596 YJEFN3 -0.38 -8.47 -0.32 1.74e-16 Bipolar disorder; BRCA cis rs7551345 0.653 rs7528098 chr1:31699435 A/G cg19084893 chr1:31688959 NA -0.47 -10.07 -0.37 3.05e-22 Schizophrenia; BRCA cis rs7264396 0.563 rs2425146 chr20:34355268 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.54 -0.42 3.97e-28 Total cholesterol levels; BRCA cis rs7927592 0.956 rs7124078 chr11:68298633 G/T cg20283391 chr11:68216788 NA -0.44 -8.59 -0.32 6.6e-17 Total body bone mineral density; BRCA cis rs4243830 0.510 rs7518459 chr1:6596678 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -17.75 -0.57 1.3e-57 Body mass index; BRCA cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.932 rs11934968 chr4:17667766 A/G cg04450456 chr4:17643702 FAM184B 0.34 9.26 0.34 2.99e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6570726 0.967 rs374728 chr6:145854598 T/A cg23711669 chr6:146136114 FBXO30 0.64 14.99 0.51 9.22e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.9 -0.33 5.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg06550200 chr5:1325588 CLPTM1L -0.66 -14.14 -0.49 1.13e-39 Lung cancer; BRCA cis rs910316 0.763 rs175047 chr14:75479039 C/G cg23033748 chr14:75592666 NEK9 -0.33 -7.86 -0.3 1.65e-14 Height; BRCA cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7267979 1.000 rs447722 chr20:25443510 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg08807101 chr21:30365312 RNF160 0.4 8.53 0.32 1.08e-16 Pancreatic cancer; BRCA cis rs9868809 0.505 rs35064573 chr3:48740280 C/A cg00383909 chr3:49044727 WDR6 0.6 10.99 0.4 7.27e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs6430585 0.591 rs309170 chr2:136672775 C/T cg07169764 chr2:136633963 MCM6 1.03 21.49 0.65 1.75e-77 Corneal structure; BRCA cis rs7949030 0.626 rs11231145 chr11:62328854 G/A cg11742103 chr11:62369870 EML3;MTA2 0.55 13.73 0.48 8.44e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg13880726 chr7:1868755 MAD1L1 0.51 10.14 0.37 1.6e-22 Bipolar disorder and schizophrenia; BRCA cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.46 0.63 6.24e-72 Smoking behavior; BRCA cis rs4285028 0.747 rs7610298 chr3:121419100 T/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.97 -0.48 6.66e-39 Multiple sclerosis; BRCA cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs1475911 1.000 rs12482477 chr21:43517233 T/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.47 -9.29 -0.35 2.35e-19 IgG glycosylation; BRCA cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.48 0.35 4.92e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg03264133 chr6:25882463 NA -0.54 -12.19 -0.43 6.7e-31 Blood metabolite levels; BRCA cis rs7520050 0.966 rs6675946 chr1:46371774 G/T cg24296786 chr1:45957014 TESK2 0.43 9.85 0.36 2.18e-21 Red blood cell count;Reticulocyte count; BRCA cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg08917208 chr2:24149416 ATAD2B 1.05 14.29 0.49 2.21e-40 Lymphocyte counts; BRCA cis rs514406 0.929 rs562178 chr1:53319562 T/C cg08859206 chr1:53392774 SCP2 -0.51 -11.15 -0.4 1.68e-26 Monocyte count; BRCA cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.9 14.11 0.49 1.47e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg08219700 chr8:58056026 NA 0.45 8.24 0.31 9.41e-16 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs56286037 chr7:98019522 C/T cg01877450 chr7:97915802 BRI3 -0.39 -8.84 -0.33 9.37e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs4722166 0.598 rs4722179 chr7:22803861 C/A cg05472934 chr7:22766657 IL6 0.4 9.83 0.36 2.51e-21 Lung cancer; BRCA cis rs909002 0.886 rs10798880 chr1:32097088 G/T cg13919466 chr1:32135498 COL16A1 -0.27 -9.03 -0.34 1.98e-18 Intelligence (multi-trait analysis); BRCA cis rs10911232 0.507 rs10797821 chr1:183012559 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 16.92 0.56 2.52e-53 Hypertriglyceridemia; BRCA cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg16586182 chr3:47516702 SCAP 0.52 11.75 0.42 5.36e-29 Colorectal cancer; BRCA cis rs13053817 1.000 rs78186489 chr22:29845703 C/A cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.49 -9.62 -0.36 1.48e-20 Carotid atherosclerosis in HIV infection; BRCA cis rs67460515 0.500 rs1562464 chr3:160681614 G/A cg03342759 chr3:160939853 NMD3 -0.64 -12.76 -0.45 2.28e-33 Parkinson's disease; BRCA cis rs56399783 0.901 rs17132594 chr7:2775102 G/A cg19731401 chr7:2775893 GNA12 0.5 8.01 0.3 5.52e-15 Childhood ear infection; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.65 13.81 0.48 3.62e-38 Lymphocyte counts; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg02951883 chr7:2050386 MAD1L1 0.54 12.37 0.44 1.15e-31 Bipolar disorder and schizophrenia; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.75 -0.33 1.92e-17 Total body bone mineral density; BRCA cis rs2404602 0.647 rs12910081 chr15:77022959 G/C cg23625390 chr15:77176239 SCAPER -0.56 -14.11 -0.49 1.5e-39 Blood metabolite levels; BRCA cis rs3008870 1.000 rs2985824 chr1:67410171 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.97 -22.39 -0.66 1.98e-82 Lymphocyte percentage of white cells; BRCA trans rs7618501 0.633 rs35065728 chr3:50009176 T/C cg21659725 chr3:3221576 CRBN 0.45 11.16 0.4 1.49e-26 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg25036284 chr2:26402008 FAM59B 0.91 15.8 0.53 1.06e-47 Gut microbiome composition (summer); BRCA cis rs926392 0.640 rs4616534 chr20:37693564 G/A cg16355469 chr20:37678765 NA 0.53 11.59 0.42 2.56e-28 Dialysis-related mortality; BRCA cis rs561341 1.000 rs4795669 chr17:30244701 C/T cg23018236 chr17:30244563 NA -0.72 -11.87 -0.42 1.74e-29 Hip circumference adjusted for BMI; BRCA cis rs290268 0.874 rs290990 chr9:93561695 A/G cg02608019 chr9:93564028 SYK -0.44 -9.57 -0.35 2.36e-20 Platelet count; BRCA cis rs7647973 0.593 rs9870755 chr3:49809841 A/G cg03060546 chr3:49711283 APEH 0.56 9.84 0.36 2.25e-21 Menarche (age at onset); BRCA cis rs950169 0.614 rs765524 chr15:84681782 G/T cg12863693 chr15:85201151 NMB 0.45 8.41 0.32 2.63e-16 Schizophrenia; BRCA cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg20503657 chr10:835505 NA 0.9 16.21 0.54 9.35e-50 Eosinophil percentage of granulocytes; BRCA cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.74e-21 Colorectal cancer; BRCA cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg03433033 chr1:76189801 ACADM 0.69 12.93 0.46 3.86e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2066819 1.000 rs77120931 chr12:56646213 A/C cg26734620 chr12:56694298 CS 0.86 10.01 0.37 5.16e-22 Psoriasis vulgaris; BRCA cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA trans rs2832077 0.527 rs2738953 chr21:30238363 G/C cg14791747 chr16:20752902 THUMPD1 -0.41 -12.5 -0.44 3.2e-32 Cognitive test performance; BRCA cis rs8078723 0.802 rs9303283 chr17:38192633 A/G cg17467752 chr17:38218738 THRA 0.68 17.57 0.57 1.13e-56 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); BRCA cis rs757110 0.770 rs11024271 chr11:17395540 T/C cg03864215 chr11:17408437 KCNJ11 -0.26 -7.82 -0.3 2.13e-14 Type 2 diabetes; BRCA cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg12698349 chr2:225449008 CUL3 0.6 13.21 0.46 2.17e-35 IgE levels in asthmatics (D.p. specific); BRCA cis rs4478137 0.931 rs3967762 chr4:164244976 T/C cg06758707 chr4:164254230 NPY1R 0.56 12.25 0.44 3.81e-31 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs931812 0.895 rs4734016 chr8:101910071 C/T cg20993868 chr7:22813445 NA 0.57 16.07 0.54 4.87e-49 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg26769984 chr7:1090371 C7orf50 0.59 10.49 0.38 7.51e-24 Bronchopulmonary dysplasia; BRCA cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg21427119 chr20:30132790 HM13 -0.43 -9.25 -0.34 3.28e-19 Mean corpuscular hemoglobin; BRCA cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg20887711 chr4:1340912 KIAA1530 -0.62 -13.73 -0.48 8.45e-38 Longevity; BRCA cis rs910316 0.935 rs175422 chr14:75627319 T/A cg08847533 chr14:75593920 NEK9 -0.88 -22.45 -0.66 9.64e-83 Height; BRCA trans rs6461049 0.765 rs3800908 chr7:2159437 C/T cg04565464 chr8:145669602 NFKBIL2 0.34 8.48 0.32 1.55e-16 Schizophrenia; BRCA cis rs11105298 0.891 rs11105316 chr12:89925200 T/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.41 -0.35 9.05e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs17376456 1.000 rs34068652 chr5:93563319 G/A cg25358565 chr5:93447407 FAM172A 1.19 18.52 0.59 1.28e-61 Diabetic retinopathy; BRCA cis rs965469 0.779 rs2207995 chr20:3294484 T/C cg25506879 chr20:3388711 C20orf194 -0.43 -8.71 -0.33 2.61e-17 IFN-related cytopenia; BRCA cis rs2115536 0.692 rs8036559 chr15:80170563 C/T cg02196730 chr15:80188777 MTHFS 0.37 8.53 0.32 1.05e-16 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg09184832 chr6:79620586 NA -0.52 -11.62 -0.42 1.89e-28 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.967 rs17411375 chr3:47395135 C/T cg16586182 chr3:47516702 SCAP 0.61 14.15 0.49 9.21e-40 Colorectal cancer; BRCA cis rs9399135 0.967 rs4895439 chr6:135318854 A/T cg24558204 chr6:135376177 HBS1L 0.45 12.42 0.44 7.31e-32 Red blood cell count; BRCA cis rs2404618 0.624 rs28439223 chr8:1476901 C/G cg13402656 chr8:1511478 DLGAP2 -0.5 -11.64 -0.42 1.62e-28 Lung cancer; BRCA cis rs17685 0.712 rs59659102 chr7:75710114 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.43 -9.66 -0.36 1.03e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg03213289 chr20:61660250 NA 0.62 16.47 0.55 4.8e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs4268898 0.552 rs12621083 chr2:24367540 C/T cg06627628 chr2:24431161 ITSN2 0.4 8.51 0.32 1.24e-16 Asthma; BRCA cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg05985134 chr18:33552581 C18orf21 0.64 11.57 0.42 2.93e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6088813 1.000 rs6087698 chr20:33948919 A/G cg14752227 chr20:34000481 UQCC -0.41 -8.77 -0.33 1.65e-17 Height; BRCA cis rs6066835 1.000 rs6122720 chr20:47351095 G/A cg18078177 chr20:47281410 PREX1 0.67 8.08 0.3 3.14e-15 Multiple myeloma; BRCA trans rs61931739 0.635 rs7979207 chr12:33910566 C/T cg26384229 chr12:38710491 ALG10B -0.39 -8.93 -0.33 4.58e-18 Morning vs. evening chronotype; BRCA cis rs73086581 1.000 rs6116130 chr20:3947026 A/T cg02187196 chr20:3869020 PANK2 0.51 9.28 0.34 2.51e-19 Response to antidepressants in depression; BRCA cis rs9325144 0.600 rs12297194 chr12:38735803 A/G cg26384229 chr12:38710491 ALG10B -0.47 -12.15 -0.43 1.04e-30 Morning vs. evening chronotype; BRCA trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.67 0.55 4.32e-52 Morning vs. evening chronotype; BRCA cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.44 0.44 5.83e-32 Bipolar disorder; BRCA cis rs1215050 0.791 rs165247 chr4:98692399 A/G cg05340658 chr4:99064831 C4orf37 0.45 10.28 0.38 4.98e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg13256891 chr4:100009986 ADH5 0.54 9.99 0.37 6.16e-22 Smoking initiation; BRCA cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg12641515 chr19:46296257 DMWD -0.57 -12.86 -0.45 7.72e-34 Coronary artery disease; BRCA cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.78 18.57 0.59 6.57e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9790314 0.586 rs11710916 chr3:161130070 A/G cg03342759 chr3:160939853 NMD3 -0.63 -14.14 -0.49 1.14e-39 Morning vs. evening chronotype; BRCA cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg19628046 chr18:33552617 C18orf21 0.52 10.82 0.39 3.6e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs10496034 1.000 rs79756117 chr2:55156858 C/T cg16098955 chr2:55172992 EML6 0.51 9.15 0.34 7.68e-19 Refractive astigmatism; BRCA trans rs11098499 0.908 rs71614449 chr4:120387055 C/T cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA trans rs4512344 0.509 rs2409784 chr8:11396856 G/T cg08975724 chr8:8085496 FLJ10661 -0.39 -8.34 -0.31 4.63e-16 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs6684514 1.000 rs12041164 chr1:156279811 G/A cg16558208 chr1:156270281 VHLL 0.34 8.07 0.3 3.48e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg09060608 chr5:178986726 RUFY1 0.54 13.13 0.46 4.75e-35 Lung cancer; BRCA cis rs1707322 1.000 rs785506 chr1:46540652 C/T cg03146154 chr1:46216737 IPP -0.44 -9.64 -0.36 1.27e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2011503 1.000 rs4808206 chr19:19645645 C/A cg11584989 chr19:19387371 SF4 0.65 13.84 0.48 2.88e-38 Bipolar disorder; BRCA trans rs9325144 0.555 rs2387847 chr12:38687434 C/T cg23762105 chr12:34175262 ALG10 -0.36 -9.06 -0.34 1.58e-18 Morning vs. evening chronotype; BRCA cis rs9368481 0.524 rs9393768 chr6:26885619 A/G cg12292205 chr6:26970375 C6orf41 0.64 14.51 0.5 1.84e-41 Autism spectrum disorder or schizophrenia; BRCA cis rs12367572 0.965 rs10785539 chr12:45233023 G/C cg04608330 chr12:45269318 NELL2 -0.6 -13.41 -0.47 2.66e-36 Gut microbiome composition (summer); BRCA cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.57 12.07 0.43 2.31e-30 Age-related macular degeneration (geographic atrophy); BRCA cis rs614226 0.938 rs787824 chr12:120924638 A/G cg01236616 chr12:121019343 POP5 -1.18 -26.56 -0.72 2.67e-105 Type 1 diabetes nephropathy; BRCA cis rs12612619 0.704 rs3769139 chr2:27315714 C/T cg00617064 chr2:27272375 NA -0.33 -8.53 -0.32 1.02e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA trans rs783540 0.967 rs783523 chr15:83283555 A/G cg18393722 chr15:85113863 UBE2QP1 0.27 8.34 0.31 4.57e-16 Schizophrenia; BRCA cis rs7917772 0.546 rs10883743 chr10:104338389 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9807989 0.507 rs2058659 chr2:103054556 A/G cg03938978 chr2:103052716 IL18RAP -0.3 -8.53 -0.32 1.03e-16 Asthma; BRCA cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.37 -9.2 -0.34 5.08e-19 Blood protein levels;Circulating chemerin levels; BRCA cis rs1395 0.744 rs11126929 chr2:27472027 C/T cg23587288 chr2:27483067 SLC30A3 0.38 8.89 0.33 6.27e-18 Blood metabolite levels; BRCA cis rs9790314 0.967 rs1382427 chr3:161032576 T/C cg03342759 chr3:160939853 NMD3 -0.64 -13.57 -0.47 4.61e-37 Morning vs. evening chronotype; BRCA cis rs600231 0.577 rs12269965 chr11:65232087 C/T cg01292856 chr11:65242576 NA 0.67 14.92 0.51 2.15e-43 Bone mineral density; BRCA cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg21918786 chr6:109611834 NA -0.44 -11.86 -0.42 1.9e-29 Reticulocyte fraction of red cells; BRCA cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.46 -0.44 4.72e-32 Bipolar disorder; BRCA cis rs9814567 1.000 rs7429866 chr3:134236306 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.88 0.62 8.32e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs700651 0.789 rs882954 chr2:198907444 A/G cg00792783 chr2:198669748 PLCL1 0.39 8.59 0.32 6.61e-17 Intracranial aneurysm; BRCA cis rs3772130 0.962 rs13433692 chr3:121484714 G/T cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.75 0.39 7.12e-25 Cognitive performance; BRCA cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg18016565 chr1:150552671 MCL1 -0.42 -9.61 -0.36 1.64e-20 Urate levels; BRCA cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.45 8.02 0.3 5.1e-15 Schizophrenia; BRCA cis rs2882667 0.690 rs288010 chr5:138200029 A/C cg04439458 chr5:138467593 SIL1 0.31 7.94 0.3 8.86e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -10.07 -0.37 3.01e-22 Extrinsic epigenetic age acceleration; BRCA cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.4 -9.28 -0.34 2.59e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs17818399 0.890 rs34544165 chr2:46836906 A/G cg02822958 chr2:46747628 ATP6V1E2 0.49 9.74 0.36 5.36e-21 Height; BRCA cis rs9815354 0.812 rs73069240 chr3:41950973 A/T cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs9420 0.809 rs11600169 chr11:57464945 T/A cg19752551 chr11:57585705 CTNND1 -0.5 -12.27 -0.44 3.09e-31 Schizophrenia; BRCA cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg06238570 chr21:40685208 BRWD1 -0.47 -9.38 -0.35 1.14e-19 Cognitive function; BRCA cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.36e-16 Schizophrenia; BRCA cis rs9462027 0.630 rs9469871 chr6:34745007 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.0 -0.3 5.77e-15 Systemic lupus erythematosus; BRCA cis rs3733585 0.673 rs4455410 chr4:9953297 C/T cg11266682 chr4:10021025 SLC2A9 0.4 10.61 0.39 2.39e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg23711669 chr6:146136114 FBXO30 -0.73 -15.02 -0.51 6.63e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs12517041 1.000 rs10068478 chr5:23297003 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs10911363 0.592 rs2275675 chr1:183439483 C/T cg09173681 chr1:183549694 NCF2 -0.48 -10.39 -0.38 1.79e-23 Systemic lupus erythematosus; BRCA trans rs6089829 0.962 rs3746747 chr20:61667631 T/C cg17470723 chr8:74884337 TCEB1 0.44 9.07 0.34 1.4e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs12474201 0.928 rs12998753 chr2:46938385 A/G cg06386533 chr2:46925753 SOCS5 0.91 19.84 0.62 1.33e-68 Height; BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg08219700 chr8:58056026 NA 0.57 9.6 0.35 1.83e-20 Developmental language disorder (linguistic errors); BRCA trans rs783540 0.967 rs1864699 chr15:83323318 A/G cg18393722 chr15:85113863 UBE2QP1 0.26 8.18 0.31 1.56e-15 Schizophrenia; BRCA cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg04733989 chr22:42467013 NAGA 0.37 8.43 0.32 2.23e-16 Cognitive function; BRCA cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg08822215 chr16:89438651 ANKRD11 0.41 9.1 0.34 1.16e-18 Multiple myeloma (IgH translocation); BRCA cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg20933634 chr6:27740509 NA 0.47 9.3 0.35 2.17e-19 Parkinson's disease; BRCA cis rs1372520 0.684 rs2619356 chr4:90750844 C/T cg15133208 chr4:90757351 SNCA -0.39 -7.97 -0.3 7.33e-15 Neuroticism; BRCA cis rs9463078 0.774 rs7740083 chr6:45274742 G/A cg25276700 chr6:44698697 NA -0.36 -8.11 -0.31 2.64e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9300255 0.537 rs10772993 chr12:123644714 A/G cg05973401 chr12:123451056 ABCB9 0.41 7.94 0.3 9.17e-15 Neutrophil percentage of white cells; BRCA cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg05872129 chr22:39784769 NA 0.52 11.69 0.42 9.13e-29 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg13010199 chr12:38710504 ALG10B 0.45 9.39 0.35 1.08e-19 Bladder cancer; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg24642844 chr7:1081250 C7orf50 -0.89 -16.33 -0.54 2.28e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs9831754 0.704 rs9836909 chr3:78451594 A/G cg06138941 chr3:78371609 NA -0.61 -12.97 -0.46 2.67e-34 Calcium levels; BRCA cis rs1878931 0.517 rs17685105 chr16:3413749 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.85 -20.78 -0.64 1.13e-73 Body mass index (adult); BRCA cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg24642439 chr20:33292090 TP53INP2 0.7 16.04 0.54 6.96e-49 Coronary artery disease; BRCA cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs1983170 0.736 rs4484968 chr1:92012005 C/A cg25838465 chr1:92012736 NA 0.46 8.13 0.31 2.19e-15 Eosinophil percentage of white cells; BRCA cis rs6570726 0.818 rs9399555 chr6:145877554 T/C cg23711669 chr6:146136114 FBXO30 0.71 16.85 0.55 5.23e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs3806843 1.000 rs2879089 chr5:140191893 A/T cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.72 -0.36 6.63e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.33 0.35 1.64e-19 Tonsillectomy; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.2 -0.43 6.44e-31 Alzheimer's disease; BRCA cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 11.86 0.42 1.89e-29 Bipolar disorder; BRCA cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -9.44 -0.35 6.59e-20 Joint mobility (Beighton score); BRCA cis rs6820391 0.816 rs6826933 chr4:54445715 C/T cg04173182 chr4:54446035 LNX1 0.53 12.13 0.43 1.27e-30 Cervical artery dissection; BRCA cis rs11585357 0.947 rs6684387 chr1:17611519 T/C cg08277548 chr1:17600880 PADI3 0.6 10.87 0.4 2.22e-25 Hair shape; BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg25036284 chr2:26402008 FAM59B -0.63 -10.51 -0.38 6.14e-24 Gut microbiome composition (summer); BRCA cis rs524281 0.861 rs10750778 chr11:65948648 T/C cg16950941 chr11:66035639 RAB1B -0.37 -7.82 -0.3 2.14e-14 Electroencephalogram traits; BRCA cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg14664628 chr15:75095509 CSK -0.78 -19.13 -0.6 7.7e-65 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs1538970 0.816 rs10789464 chr1:45959102 C/T cg05343316 chr1:45956843 TESK2 0.7 14.51 0.5 1.98e-41 Platelet count; BRCA trans rs11098499 0.863 rs1480940 chr4:120457682 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.15 0.31 1.88e-15 Corneal astigmatism; BRCA trans rs12517041 0.935 rs10061491 chr5:23296773 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs7264396 0.635 rs6060685 chr20:34512023 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -15.0 -0.51 8.89e-44 Total cholesterol levels; BRCA cis rs11190604 1.000 rs4919464 chr10:102221195 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.15 0.4 1.7e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs992157 0.804 rs6758540 chr2:219138625 A/G cg00012203 chr2:219082015 ARPC2 -0.5 -9.63 -0.36 1.42e-20 Colorectal cancer; BRCA cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg27446573 chr6:127587934 RNF146 0.89 20.5 0.63 3.86e-72 Breast cancer; BRCA cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg10547057 chr6:26987810 LOC100270746;C6orf41 0.33 9.93 0.37 1.07e-21 Autism spectrum disorder or schizophrenia; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg04944784 chr2:26401820 FAM59B 1.0 16.79 0.55 1.16e-52 Gut microbiome composition (summer); BRCA cis rs1395 0.744 rs11126936 chr2:27483101 A/C cg23587288 chr2:27483067 SLC30A3 0.37 8.61 0.32 5.8e-17 Blood metabolite levels; BRCA cis rs7520050 0.778 rs2088102 chr1:46032974 T/C cg24296786 chr1:45957014 TESK2 0.47 11.04 0.4 4.49e-26 Red blood cell count;Reticulocyte count; BRCA trans rs66887589 0.967 rs59516282 chr4:120502016 G/A cg25214090 chr10:38739885 LOC399744 -0.37 -8.5 -0.32 1.36e-16 Diastolic blood pressure; BRCA cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.56 10.87 0.39 2.33e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg11752832 chr7:134001865 SLC35B4 0.52 13.48 0.47 1.31e-36 Mean platelet volume; BRCA cis rs17620991 1.000 rs66651482 chr7:40851242 G/T cg05119115 chr7:40866195 C7orf10 -0.56 -8.67 -0.32 3.66e-17 Alcohol dependence; BRCA cis rs760805 1.000 rs11249204 chr1:25261740 C/T cg22509179 chr1:25234806 RUNX3 0.57 14.74 0.5 1.49e-42 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg20476274 chr7:133979776 SLC35B4 -0.45 -11.64 -0.42 1.54e-28 Mean platelet volume; BRCA cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg24642439 chr20:33292090 TP53INP2 0.54 11.77 0.42 4.49e-29 Glomerular filtration rate (creatinine); BRCA cis rs28669119 0.749 rs244750 chr5:88147192 T/C cg18498987 chr5:88179539 MEF2C 0.44 8.04 0.3 4.32e-15 Schizophrenia; BRCA cis rs877282 0.945 rs11253396 chr10:789754 C/T cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs919433 0.680 rs788023 chr2:198283305 T/C cg00792783 chr2:198669748 PLCL1 0.38 8.39 0.32 3.12e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg18765753 chr7:1198926 ZFAND2A -0.4 -7.99 -0.3 6.11e-15 Bronchopulmonary dysplasia; BRCA cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg06238570 chr21:40685208 BRWD1 -0.4 -8.14 -0.31 2.02e-15 Menarche (age at onset); BRCA cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg26031613 chr14:104095156 KLC1 -0.55 -9.5 -0.35 4.09e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9649465 1.000 rs3807640 chr7:123338713 G/C cg04330084 chr7:123175371 IQUB -0.33 -8.82 -0.33 1.05e-17 Migraine; BRCA cis rs7737355 0.947 rs31257 chr5:130828715 C/G cg06307176 chr5:131281290 NA 0.52 10.4 0.38 1.71e-23 Life satisfaction; BRCA cis rs4664304 0.620 rs10929958 chr2:160720538 A/G cg14819504 chr2:160761413 LY75 0.34 8.47 0.32 1.65e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1864400 0.696 rs2742239 chr10:43621712 A/G cg02780029 chr10:43622663 RET -0.35 -7.86 -0.3 1.64e-14 Hirschsprung disease; BRCA cis rs7246657 0.943 rs4417644 chr19:37852472 A/G cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs2806561 0.894 rs628106 chr1:23537685 C/T cg12483005 chr1:23474871 LUZP1 0.37 8.02 0.3 4.97e-15 Height; BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.26 0.34 3.1e-19 Tonsillectomy; BRCA cis rs7584330 0.554 rs6760890 chr2:238400645 G/A cg14458575 chr2:238380390 NA 0.53 8.68 0.32 3.27e-17 Prostate cancer; BRCA cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.75 0.33 1.9e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs5758511 0.680 rs739147 chr22:42671066 T/G cg00645731 chr22:42541494 CYP2D7P1 0.58 11.18 0.4 1.24e-26 Birth weight; BRCA cis rs9341808 0.718 rs9361584 chr6:80819946 G/C cg08355045 chr6:80787529 NA 0.37 9.35 0.35 1.43e-19 Sitting height ratio; BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg27071517 chr21:31768726 KRTAP13-1 0.28 7.87 0.3 1.53e-14 HDL cholesterol; BRCA cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg24692254 chr21:30365293 RNF160 0.78 21.63 0.65 2.97e-78 Dental caries; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.19 -0.34 5.52e-19 Total body bone mineral density; BRCA cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.56 0.76 1.12e-121 Cognitive ability; BRCA cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg02820040 chr2:241836501 C2orf54 -0.49 -8.96 -0.33 3.63e-18 Urinary metabolites; BRCA cis rs12541635 0.677 rs7460291 chr8:107057861 A/G cg10147462 chr8:107024639 NA 0.39 10.31 0.38 3.63e-23 Age of smoking initiation; BRCA cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg12373951 chr3:133503437 NA 0.44 10.4 0.38 1.68e-23 Iron status biomarkers; BRCA cis rs9400271 0.632 rs9384703 chr6:109586803 A/G cg01475377 chr6:109611718 NA -0.42 -10.13 -0.37 1.81e-22 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs2242116 0.796 rs2290546 chr3:46965197 C/G cg16586182 chr3:47516702 SCAP -0.44 -8.84 -0.33 9.43e-18 Birth weight; BRCA cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg15605315 chr1:45957053 TESK2 -0.46 -9.27 -0.34 2.92e-19 High light scatter reticulocyte count; BRCA cis rs4635969 0.718 rs27068 chr5:1347239 C/T cg07493874 chr5:1342172 CLPTM1L -0.35 -8.06 -0.3 3.81e-15 Testicular germ cell tumor;Testicular germ cell cancer; BRCA cis rs9296092 0.517 rs7775914 chr6:33518110 T/C cg13560919 chr6:33536144 NA -0.85 -18.53 -0.59 1.1e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11644478 chr21:40555479 PSMG1 0.85 19.85 0.62 1.1e-68 Cognitive function; BRCA cis rs9649465 0.967 rs12539091 chr7:123291314 C/T cg04330084 chr7:123175371 IQUB -0.33 -9.05 -0.34 1.71e-18 Migraine; BRCA cis rs28830936 1.000 rs4923905 chr15:41909889 G/A cg17847044 chr15:42102381 MAPKBP1 -0.32 -9.23 -0.34 3.76e-19 Diastolic blood pressure; BRCA cis rs10883723 0.810 rs10786671 chr10:104271303 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.12 0.62 4.1e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg01448562 chr3:133502909 NA -0.62 -14.85 -0.51 4.63e-43 Iron status biomarkers; BRCA cis rs9682041 0.660 rs13089256 chr3:170113601 G/A cg11886554 chr3:170076028 SKIL 0.51 10.13 0.37 1.76e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg15704280 chr7:45808275 SEPT13 0.8 18.66 0.59 2.37e-62 Coronary artery disease; BRCA cis rs10929956 0.760 rs2729704 chr2:160707866 T/A cg02280532 chr2:160761244 LY75 -0.35 -7.81 -0.3 2.29e-14 Crohn's disease-related phenotypes; BRCA cis rs7044106 0.791 rs4617229 chr9:123480696 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.67 14.42 0.5 5.42e-41 Hip circumference adjusted for BMI; BRCA cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -9.15 -0.34 7.52e-19 Schizophrenia; BRCA cis rs6977660 0.652 rs10267417 chr7:19843797 C/T cg05791153 chr7:19748676 TWISTNB 0.59 10.72 0.39 8.76e-25 Thyroid stimulating hormone; BRCA cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg13393036 chr8:95962371 TP53INP1 -0.29 -7.84 -0.3 1.91e-14 Type 2 diabetes; BRCA cis rs7824557 0.806 rs34171564 chr8:11095346 C/A cg21775007 chr8:11205619 TDH -0.48 -9.41 -0.35 9.09e-20 Retinal vascular caliber; BRCA cis rs10191773 0.589 rs72831636 chr2:112948248 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.61 7.81 0.3 2.34e-14 Yeast infection; BRCA cis rs8062405 0.965 rs62037363 chr16:28865042 T/C cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg08975724 chr8:8085496 FLJ10661 -0.41 -8.73 -0.33 2.17e-17 Neuroticism; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.2 0.6 3.14e-65 Alzheimer's disease; BRCA cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg26384229 chr12:38710491 ALG10B 0.85 23.11 0.67 2.4700000000000002e-86 Heart rate; BRCA cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg10802521 chr3:52805072 NEK4 -0.31 -8.45 -0.32 1.94e-16 Electroencephalogram traits; BRCA cis rs4908760 0.730 rs10779704 chr1:8693537 A/C cg20416874 chr1:8611966 RERE -0.29 -8.29 -0.31 6.66e-16 Vitiligo; BRCA cis rs6121246 0.909 rs6058450 chr20:30343911 G/A cg13852791 chr20:30311386 BCL2L1 0.84 16.58 0.55 1.35e-51 Mean corpuscular hemoglobin; BRCA cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg24531977 chr5:56204891 C5orf35 -0.44 -8.66 -0.32 3.74e-17 Coronary artery disease; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg08088566 chr11:430123 ANO9 0.56 8.3 0.31 6.17e-16 Body mass index; BRCA cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.33 0.61 6.67e-66 Smoking behavior; BRCA cis rs473651 0.935 rs508483 chr2:239339709 T/C cg21699342 chr2:239360505 ASB1 0.53 14.06 0.49 2.49e-39 Multiple system atrophy; BRCA trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg15934090 chr1:100435551 SLC35A3 0.36 8.36 0.31 3.82e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg21573476 chr21:45109991 RRP1B -0.36 -9.63 -0.36 1.36e-20 Mean corpuscular volume; BRCA cis rs72781680 0.611 rs72781696 chr2:24267014 C/T cg20701182 chr2:24300061 SF3B14 0.68 12.9 0.45 5.2e-34 Lymphocyte counts; BRCA cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg23029597 chr12:123009494 RSRC2 -0.63 -12.71 -0.45 3.78e-33 Body mass index; BRCA cis rs10504073 0.647 rs10504072 chr8:49993083 G/A cg00325661 chr8:49890786 NA 0.44 12.45 0.44 5.05e-32 Blood metabolite ratios; BRCA cis rs7172677 0.737 rs11855234 chr15:75446834 C/A cg10253484 chr15:75165896 SCAMP2 -0.42 -7.94 -0.3 9.09e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs27434 0.561 rs151910 chr5:96156956 C/A cg16492584 chr5:96139282 ERAP1 -0.51 -12.75 -0.45 2.4e-33 Ankylosing spondylitis; BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -8.2 -0.31 1.31e-15 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs11608355 0.515 rs2287184 chr12:109970251 T/C cg05360138 chr12:110035743 NA 0.73 13.59 0.47 3.77e-37 Neuroticism; BRCA trans rs11662586 0.517 rs11663082 chr18:77713494 C/T cg05926928 chr17:57297772 GDPD1 0.47 9.11 0.34 1.04e-18 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs13046373 0.562 rs12627602 chr21:32022924 G/A cg24082983 chr21:31802169 KRTAP13-4 0.32 8.17 0.31 1.69e-15 HDL cholesterol; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg05552183 chr6:42928497 GNMT 0.85 21.59 0.65 4.79e-78 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11690935 0.571 rs13020884 chr2:172901699 T/G cg13550731 chr2:172543902 DYNC1I2 0.56 13.91 0.48 1.22e-38 Schizophrenia; BRCA cis rs1975991 0.765 rs4634106 chr3:187953513 C/G cg15417654 chr3:187959138 LPP 0.33 7.88 0.3 1.46e-14 White matter integrity (bipolar disorder risk interaction); BRCA cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg04455712 chr21:45112962 RRP1B 0.38 9.76 0.36 4.48e-21 Mean corpuscular volume; BRCA cis rs1401999 0.934 rs1132776 chr3:183696402 A/G cg01324343 chr3:183735012 ABCC5 0.81 20.44 0.63 8.24e-72 Anterior chamber depth; BRCA cis rs35146811 0.735 rs1637001 chr7:99808151 G/A cg13334819 chr7:99746414 C7orf59 0.34 7.92 0.3 1.06e-14 Coronary artery disease; BRCA cis rs17685 0.753 rs10251863 chr7:75790192 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7246657 0.679 rs12461113 chr19:38083188 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs6763687 0.756 rs4894522 chr3:171770001 A/G cg16233210 chr3:171778391 FNDC3B 0.37 7.91 0.3 1.13e-14 Red cell distribution width; BRCA trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg03929089 chr4:120376271 NA 0.71 16.53 0.55 2.38e-51 Height; BRCA cis rs4302748 0.862 rs58221920 chr7:36181963 C/A cg24442661 chr7:36192818 EEPD1 0.46 8.74 0.33 2.11e-17 Platelet count; BRCA cis rs68170813 0.559 rs76145119 chr7:107052368 C/T cg02696742 chr7:106810147 HBP1 -0.54 -8.13 -0.31 2.17e-15 Coronary artery disease; BRCA cis rs12681288 0.823 rs2701907 chr8:1003292 A/G cg04851639 chr8:1020857 NA -0.34 -10.57 -0.39 3.55e-24 Schizophrenia; BRCA cis rs6582630 0.519 rs11495699 chr12:38286219 G/T cg13010199 chr12:38710504 ALG10B 0.52 10.31 0.38 3.8e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2559856 0.967 rs2695297 chr12:102082218 T/C cg12213457 chr12:102090980 CHPT1 -0.37 -8.03 -0.3 4.74e-15 Blood protein levels; BRCA cis rs2274273 1.000 rs8011834 chr14:55625977 A/C cg04306507 chr14:55594613 LGALS3 0.31 8.64 0.32 4.37e-17 Protein biomarker; BRCA cis rs9323205 0.862 rs11629399 chr14:51612814 T/C cg23942311 chr14:51606299 NA -0.44 -9.26 -0.34 3.06e-19 Cancer; BRCA cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg03146154 chr1:46216737 IPP 0.53 11.86 0.42 1.84e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7647973 0.626 rs35129566 chr3:49866584 T/G cg03060546 chr3:49711283 APEH -0.58 -10.21 -0.37 8.95e-23 Menarche (age at onset); BRCA cis rs16976116 0.851 rs11855907 chr15:55494634 A/C cg11288833 chr15:55489084 RSL24D1 0.48 10.68 0.39 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2243480 1.000 rs6460274 chr7:65628484 T/A cg18252515 chr7:66147081 NA 1.03 15.25 0.52 5.04e-45 Diabetic kidney disease; BRCA trans rs116095464 0.558 rs55833259 chr5:286728 G/A cg00938859 chr5:1591904 SDHAP3 0.69 9.4 0.35 9.53e-20 Breast cancer; BRCA cis rs12431939 1.000 rs12433445 chr14:51666091 G/A cg23942311 chr14:51606299 NA -0.43 -8.08 -0.3 3.2e-15 Cancer; BRCA cis rs6815814 0.950 rs113465719 chr4:38808045 A/T cg06935464 chr4:38784597 TLR10 0.5 8.27 0.31 7.76e-16 Breast cancer; BRCA trans rs11098499 0.954 rs10006525 chr4:120408931 T/G cg25214090 chr10:38739885 LOC399744 0.55 12.61 0.45 1.08e-32 Corneal astigmatism; BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs7586879 0.828 rs13012304 chr2:25122246 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.35 0.35 1.43e-19 Body mass index; BRCA cis rs758324 0.947 rs2088719 chr5:131184439 C/T cg06307176 chr5:131281290 NA 0.53 10.13 0.37 1.87e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs78456975 0.506 rs6756310 chr2:1549809 A/G cg12573674 chr2:1569213 NA -0.54 -11.41 -0.41 1.46e-27 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg27279351 chr12:120934652 DYNLL1 0.56 13.26 0.46 1.28e-35 High light scatter reticulocyte count; BRCA cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg16230307 chr14:35515116 FAM177A1 0.69 14.47 0.5 3.14e-41 Psoriasis; BRCA cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg12386194 chr3:101231763 SENP7 0.48 10.04 0.37 4.03e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg20019365 chr2:219134978 PNKD;AAMP 0.42 9.32 0.35 1.83e-19 Colorectal cancer; BRCA cis rs7927771 0.524 rs10838732 chr11:47607940 C/G cg20307385 chr11:47447363 PSMC3 0.45 10.38 0.38 1.9e-23 Subjective well-being; BRCA cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg19784903 chr17:45786737 TBKBP1 0.34 8.11 0.31 2.54e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs796364 0.865 rs769948 chr2:200728475 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.83 0.42 2.57e-29 Schizophrenia; BRCA cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg04317338 chr11:64019027 PLCB3 0.53 9.21 0.34 4.46e-19 Mean platelet volume; BRCA cis rs2066819 1.000 rs2291361 chr12:56717805 G/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA trans rs4596713 0.568 rs6560584 chr9:71747172 A/G cg16512924 chr15:28394682 HERC2 0.39 9.39 0.35 1.04e-19 Headache; BRCA cis rs4803468 1.000 rs3816037 chr19:41918009 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -25.54 -0.71 1.07e-99 Height; BRCA cis rs9790314 0.846 rs6441371 chr3:161008727 C/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.28 -0.49 2.26e-40 Morning vs. evening chronotype; BRCA trans rs9467711 0.790 rs13198716 chr6:26582035 A/G cg01620082 chr3:125678407 NA 0.8 9.25 0.34 3.35e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs7833986 0.501 rs2719255 chr8:57036658 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.06 0.46 9.86e-35 Height; BRCA cis rs2882667 0.861 rs11959727 chr5:138396965 C/T cg04439458 chr5:138467593 SIL1 -0.35 -9.55 -0.35 2.83e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg08822215 chr16:89438651 ANKRD11 0.43 9.53 0.35 3.26e-20 Multiple myeloma (IgH translocation); BRCA trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -10.82 -0.39 3.74e-25 Monocyte count; BRCA cis rs826838 1.000 rs4768328 chr12:39129315 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg07537917 chr2:241836409 C2orf54 0.45 10.04 0.37 3.99e-22 Urinary metabolites; BRCA cis rs7572733 0.555 rs7600269 chr2:198923468 C/G cg00792783 chr2:198669748 PLCL1 0.39 8.45 0.32 2e-16 Dermatomyositis; BRCA cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg26373071 chr5:1325741 CLPTM1L 0.51 12.46 0.44 4.92e-32 Lung cancer; BRCA cis rs514406 0.505 rs12726160 chr1:53175099 A/G cg16325326 chr1:53192061 ZYG11B 0.78 21.0 0.64 7.22e-75 Monocyte count; BRCA cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs2559856 1.000 rs2695299 chr12:102082664 G/A cg12213457 chr12:102090980 CHPT1 -0.37 -8.07 -0.3 3.56e-15 Blood protein levels; BRCA cis rs9287719 0.649 rs6732429 chr2:10758972 C/T cg00105475 chr2:10696890 NA -0.39 -8.94 -0.33 4.31e-18 Prostate cancer; BRCA cis rs13191362 0.938 rs59067610 chr6:163030440 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.24 0.31 9.8e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs921968 0.643 rs711191 chr2:219386084 T/A cg02176678 chr2:219576539 TTLL4 0.39 10.47 0.38 8.56e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.51 9.7 0.36 7.35e-21 Aortic root size; BRCA trans rs61931739 0.534 rs11053021 chr12:34111157 C/T cg26384229 chr12:38710491 ALG10B 0.66 13.93 0.48 1.04e-38 Morning vs. evening chronotype; BRCA cis rs1691799 0.831 rs6581678 chr12:66776656 A/G cg16791601 chr12:66731901 HELB -0.61 -16.54 -0.55 2.04e-51 White blood cell count (basophil); BRCA cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.84 -0.3 1.9e-14 Aortic root size; BRCA cis rs6426558 0.515 rs7412928 chr1:227332148 C/T cg10327440 chr1:227177885 CDC42BPA -0.46 -9.04 -0.34 1.89e-18 Neutrophil percentage of white cells; BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg21782813 chr7:2030301 MAD1L1 -0.32 -8.83 -0.33 9.9e-18 Bipolar disorder and schizophrenia; BRCA cis rs17767294 0.708 rs72845896 chr6:27697645 C/G cg08851530 chr6:28072375 NA 1.11 10.08 0.37 2.81e-22 Parkinson's disease; BRCA trans rs4942242 0.659 rs1105586 chr13:44232633 C/T cg19169023 chr15:41853346 TYRO3 0.6 12.97 0.46 2.58e-34 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg06618935 chr21:46677482 NA 0.38 8.35 0.31 4.36e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.25 0.41 6.72e-27 Bipolar disorder; BRCA cis rs3857536 0.740 rs7751095 chr6:66891318 A/G cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA trans rs1997103 0.954 rs2030807 chr7:55378485 A/G cg20935933 chr6:143382018 AIG1 0.59 11.3 0.41 4.23e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10752881 1.000 rs4593781 chr1:182984983 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.61 0.55 9.32e-52 Colorectal cancer; BRCA cis rs11690935 0.921 rs908670 chr2:172690180 T/C cg13550731 chr2:172543902 DYNC1I2 -0.9 -29.49 -0.76 2.5e-121 Schizophrenia; BRCA cis rs4713118 0.513 rs149941 chr6:28001033 T/C cg10876282 chr6:28092338 ZSCAN16 0.41 8.14 0.31 2.06e-15 Parkinson's disease; BRCA cis rs6690583 0.697 rs10782537 chr1:85484473 C/T cg11262906 chr1:85462892 MCOLN2 -0.53 -10.94 -0.4 1.22e-25 Serum sulfate level; BRCA cis rs10754283 0.967 rs1320563 chr1:90121032 G/A cg21401794 chr1:90099060 LRRC8C 0.47 11.01 0.4 5.97e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs586533 0.724 rs680914 chr11:99501982 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg09324608 chr17:30823087 MYO1D 0.5 11.95 0.43 7.91e-30 Schizophrenia; BRCA cis rs514406 0.505 rs448788 chr1:53161620 A/G cg24675658 chr1:53192096 ZYG11B 0.64 14.02 0.49 3.92e-39 Monocyte count; BRCA cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -8.93 -0.33 4.5e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs739401 0.595 rs2237903 chr11:2967901 C/T cg08508325 chr11:3079039 CARS -0.36 -11.95 -0.43 7.2e-30 Longevity; BRCA cis rs7572733 0.534 rs770662 chr2:198729283 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.18 0.37 1.21e-22 Dermatomyositis; BRCA cis rs7592578 0.882 rs16832765 chr2:191468762 T/C cg10560079 chr2:191398806 TMEM194B -0.76 -12.54 -0.44 2.17e-32 Diastolic blood pressure; BRCA cis rs7727544 0.735 rs272842 chr5:131656517 A/G cg07395648 chr5:131743802 NA -0.37 -9.49 -0.35 4.33e-20 Blood metabolite levels; BRCA cis rs524281 0.692 rs10791845 chr11:65834340 C/G cg14036092 chr11:66035641 RAB1B 0.4 8.95 0.33 3.95e-18 Electroencephalogram traits; BRCA cis rs6815814 0.950 rs56289835 chr4:38811845 G/C cg02016764 chr4:38805732 TLR1 -0.6 -9.19 -0.34 5.47e-19 Breast cancer; BRCA cis rs13392177 0.672 rs4674270 chr2:219053141 G/T cg00012203 chr2:219082015 ARPC2 -0.55 -11.28 -0.41 5.04e-27 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg11814155 chr7:99998594 ZCWPW1 0.43 8.1 0.31 2.72e-15 Platelet count; BRCA cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg24110177 chr3:50126178 RBM5 -0.51 -14.57 -0.5 9.9e-42 Body mass index; BRCA cis rs7511006 1.000 rs17836662 chr22:50672154 A/G cg08875078 chr22:50639485 SELO -0.3 -7.83 -0.3 1.97e-14 Obesity-related traits; BRCA trans rs9325144 0.534 rs1843887 chr12:38692380 T/C cg23762105 chr12:34175262 ALG10 -0.36 -9.08 -0.34 1.29e-18 Morning vs. evening chronotype; BRCA cis rs7715806 0.500 rs17649266 chr5:75001252 C/T cg19683494 chr5:74908142 NA -0.51 -8.46 -0.32 1.81e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg02820040 chr2:241836501 C2orf54 -0.54 -10.25 -0.38 6.25e-23 Urinary metabolites; BRCA cis rs13064411 0.696 rs13066742 chr3:113208423 T/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.34 -0.44 1.56e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg03517284 chr6:25882590 NA -0.47 -10.66 -0.39 1.57e-24 Blood metabolite levels; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg03923535 chr7:1197113 ZFAND2A -0.45 -8.9 -0.33 5.59e-18 Longevity;Endometriosis; BRCA cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg23711669 chr6:146136114 FBXO30 0.79 18.95 0.6 6.68e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs965469 0.895 rs6051843 chr20:3400538 A/G cg25506879 chr20:3388711 C20orf194 -0.54 -10.6 -0.39 2.73e-24 IFN-related cytopenia; BRCA cis rs7824557 0.591 rs2043510 chr8:11225168 G/A cg21775007 chr8:11205619 TDH -0.62 -13.37 -0.47 4.04e-36 Retinal vascular caliber; BRCA cis rs12541635 0.677 rs6997487 chr8:106965511 A/C cg10147462 chr8:107024639 NA 0.39 10.46 0.38 9.3e-24 Age of smoking initiation; BRCA cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg07395648 chr5:131743802 NA -0.35 -7.87 -0.3 1.58e-14 Breast cancer; BRCA cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg10978503 chr1:24200527 CNR2 0.47 12.35 0.44 1.49e-31 Immature fraction of reticulocytes; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg22903471 chr2:27725779 GCKR -0.36 -8.73 -0.33 2.29e-17 Total body bone mineral density; BRCA cis rs9341808 1.000 rs9341808 chr6:80953257 C/A cg08355045 chr6:80787529 NA 0.34 9.09 0.34 1.19e-18 Sitting height ratio; BRCA cis rs9649465 0.967 rs6966470 chr7:123299855 C/T cg04330084 chr7:123175371 IQUB 0.3 8.21 0.31 1.19e-15 Migraine; BRCA cis rs1707322 0.717 rs1135850 chr1:46093692 G/A cg03146154 chr1:46216737 IPP 0.5 11.16 0.4 1.55e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -9.6 -0.36 1.77e-20 Coronary artery disease; BRCA trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.54 17.21 0.56 8.02e-55 Intelligence (multi-trait analysis); BRCA cis rs7766436 0.553 rs62391069 chr6:22610835 C/T cg13666174 chr6:22585274 NA -0.44 -7.99 -0.3 6.33e-15 Coronary artery disease; BRCA cis rs6089829 0.962 rs6062776 chr20:61663736 A/G cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.36 0.35 1.34e-19 Body mass index; BRCA cis rs9790314 1.000 rs163328 chr3:161073599 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.81 -0.51 6.87e-43 Morning vs. evening chronotype; BRCA cis rs4730250 0.654 rs6947857 chr7:106787266 T/G cg02696742 chr7:106810147 HBP1 0.62 9.87 0.36 1.82e-21 Osteoarthritis; BRCA cis rs1577917 0.958 rs13207173 chr6:86457522 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.25 -0.31 8.74e-16 Response to antipsychotic treatment; BRCA cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg15212455 chr7:39170539 POU6F2 0.45 9.88 0.36 1.57e-21 IgG glycosylation; BRCA cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg19077165 chr18:44547161 KATNAL2 0.63 14.24 0.49 3.49e-40 Personality dimensions; BRCA cis rs2204008 0.805 rs11179579 chr12:38213957 A/C cg13010199 chr12:38710504 ALG10B 0.44 8.93 0.33 4.46e-18 Bladder cancer; BRCA cis rs483180 0.512 rs606312 chr1:120222582 G/A cg19096424 chr1:120255104 PHGDH 0.45 9.83 0.36 2.5e-21 Macular telangiectasia type 2; BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg04025307 chr7:1156635 C7orf50 0.52 10.06 0.37 3.32e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs208520 0.526 rs6913344 chr6:66754285 A/C cg07460842 chr6:66804631 NA -1.01 -27.66 -0.74 2.55e-111 Exhaled nitric oxide output; BRCA cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.46 0.32 1.86e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4363385 0.818 rs423692 chr1:153005681 T/G cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs2742234 0.590 rs2505506 chr10:43645854 C/T cg15436174 chr10:43711423 RASGEF1A -0.55 -11.25 -0.41 6.55e-27 Hirschsprung disease; BRCA cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg25019033 chr10:957182 NA -0.4 -8.57 -0.32 7.85e-17 Eosinophil percentage of granulocytes; BRCA cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg05283184 chr6:79620031 NA -0.35 -8.38 -0.31 3.38e-16 Intelligence (multi-trait analysis); BRCA cis rs611744 0.647 rs864166 chr8:109249300 C/G cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs1371614 0.635 rs877273 chr2:27140022 C/T cg00617064 chr2:27272375 NA 0.31 8.01 0.3 5.29e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg06636001 chr8:8085503 FLJ10661 -0.68 -15.27 -0.52 3.95e-45 Mood instability; BRCA cis rs8038465 0.622 rs56712926 chr15:73886849 G/T cg15420318 chr15:73925796 NPTN 0.49 10.28 0.38 4.8e-23 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg13010199 chr12:38710504 ALG10B 0.56 12.58 0.45 1.42e-32 Heart rate; BRCA cis rs11690935 1.000 rs12053003 chr2:172537350 A/C cg13550731 chr2:172543902 DYNC1I2 0.93 30.62 0.77 1.89e-127 Schizophrenia; BRCA cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg09184832 chr6:79620586 NA -0.54 -12.0 -0.43 4.8e-30 Intelligence (multi-trait analysis); BRCA cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg17063962 chr7:91808500 NA 0.53 12.47 0.44 4.15e-32 Breast cancer; BRCA cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.41 -9.63 -0.36 1.43e-20 Tonsillectomy; BRCA cis rs4319547 0.661 rs10846830 chr12:122897220 C/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.33 -0.35 1.77e-19 Body mass index; BRCA trans rs3733585 0.657 rs62286568 chr4:10124889 C/T cg26043149 chr18:55253948 FECH -0.39 -8.11 -0.31 2.65e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg08392591 chr16:89556376 ANKRD11 0.41 9.39 0.35 1.02e-19 Multiple myeloma (IgH translocation); BRCA cis rs68170813 0.559 rs79978998 chr7:106845482 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.46 -0.32 1.78e-16 Coronary artery disease; BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg14789911 chr21:47582049 C21orf56 -0.38 -8.07 -0.3 3.61e-15 Testicular germ cell tumor; BRCA cis rs12477438 0.520 rs11883676 chr2:99800814 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA cis rs1577917 1.000 rs12213149 chr6:86668644 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.03 -0.3 4.72e-15 Response to antipsychotic treatment; BRCA cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg16423285 chr20:60520624 NA -0.54 -10.81 -0.39 4.04e-25 Obesity-related traits; BRCA cis rs208520 1.000 rs12200490 chr6:66976084 G/A cg07460842 chr6:66804631 NA 0.86 13.83 0.48 3.16e-38 Exhaled nitric oxide output; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.16 -0.31 1.77e-15 Total body bone mineral density; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs58799304 0.531 rs12035615 chr1:156055344 C/T cg15685922 chr1:156045208 MEX3A -0.42 -8.75 -0.33 1.92e-17 Ischemic stroke; BRCA cis rs40363 0.951 rs250632 chr16:3523047 C/T cg00484396 chr16:3507460 NAT15 0.57 8.36 0.31 3.84e-16 Tuberculosis; BRCA cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.68e-18 Motion sickness; BRCA cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg11584989 chr19:19387371 SF4 0.64 13.49 0.47 1.14e-36 Bipolar disorder; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg02592271 chr2:27665507 KRTCAP3 -0.31 -8.02 -0.3 5.02e-15 Total body bone mineral density; BRCA cis rs425277 0.606 rs451061 chr1:2075068 C/G cg24578937 chr1:2090814 PRKCZ 0.35 11.39 0.41 1.71e-27 Height; BRCA cis rs7267979 0.903 rs2500400 chr20:25354705 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -8.99 -0.33 2.87e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9811920 0.809 rs793443 chr3:99573547 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -13.02 -0.46 1.59e-34 Axial length; BRCA cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg18252515 chr7:66147081 NA -0.56 -11.32 -0.41 3.38e-27 Corneal structure; BRCA cis rs17125944 0.505 rs10483618 chr14:53203590 T/C cg13660082 chr14:53194042 PSMC6 -0.57 -8.64 -0.32 4.61e-17 Alzheimer's disease (late onset); BRCA cis rs2243480 1.000 rs465359 chr7:65558164 C/T cg18252515 chr7:66147081 NA -1.07 -15.54 -0.52 2.03e-46 Diabetic kidney disease; BRCA cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg06697600 chr4:7070879 GRPEL1 0.54 10.63 0.39 1.98e-24 Monocyte percentage of white cells; BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg11814155 chr7:99998594 ZCWPW1 0.54 9.32 0.35 1.81e-19 Platelet count; BRCA cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.61 -0.53 9.29e-47 Chronic sinus infection; BRCA cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7829975 0.742 rs1533058 chr8:8685190 A/G cg14343924 chr8:8086146 FLJ10661 0.39 8.1 0.31 2.81e-15 Mood instability; BRCA cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.96e-15 Breast cancer; BRCA cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg11663144 chr21:46675770 NA -0.64 -15.28 -0.52 3.72e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1997103 1.000 rs6968966 chr7:55411356 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.72 0.67 3.41e-84 Platelet count; BRCA cis rs11792861 0.816 rs11791845 chr9:111683898 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.99 0.3 6.37e-15 Menarche (age at onset); BRCA cis rs13136331 0.607 rs7680291 chr4:88638522 G/T cg22416721 chr4:88570574 DMP1 -0.6 -13.89 -0.48 1.68e-38 Sitting height ratio; BRCA cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.87 -0.3 1.49e-14 Electroencephalogram traits; BRCA trans rs877282 0.853 rs11596346 chr10:756673 A/T cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs2282802 0.685 rs1347143 chr5:139669386 A/G cg26211634 chr5:139558579 C5orf32 -0.33 -7.98 -0.3 7.01e-15 Intelligence (multi-trait analysis); BRCA trans rs783540 0.934 rs783530 chr15:83266549 G/C cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.37 -0.31 3.7e-16 Schizophrenia; BRCA trans rs3960554 0.808 rs867973 chr7:75686007 G/A cg19862616 chr7:65841803 NCRNA00174 0.6 11.98 0.43 5.53e-30 Eotaxin levels; BRCA cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.53 8.89 0.33 6.37e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7847628 0.587 rs12684934 chr9:123593159 C/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.31 8.36 0.31 3.78e-16 Birth weight; BRCA cis rs7715811 1.000 rs13436952 chr5:13773993 A/G cg07548982 chr5:13769939 DNAH5 -0.4 -9.07 -0.34 1.5e-18 Subclinical atherosclerosis traits (other); BRCA cis rs9646954 0.542 rs11674830 chr2:101024735 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.51 0.41 5.62e-28 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs7654587 chr4:120388406 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg13736514 chr6:26305472 NA -0.46 -14.79 -0.5 8.88e-43 Educational attainment; BRCA cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.36 -9.92 -0.37 1.1e-21 Monocyte percentage of white cells; BRCA cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.42 0.32 2.47e-16 Axial length; BRCA cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.58 -10.68 -0.39 1.36e-24 Aortic root size; BRCA cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg18964960 chr10:1102726 WDR37 0.66 9.22 0.34 4.25e-19 Eosinophil percentage of granulocytes; BRCA cis rs11098499 0.863 rs34308924 chr4:120481431 T/C cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA trans rs7824557 0.583 rs2736306 chr8:11239762 A/T cg06636001 chr8:8085503 FLJ10661 0.52 10.28 0.38 4.8e-23 Retinal vascular caliber; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 24.74 0.7 2.79e-95 Platelet count; BRCA cis rs754466 1.000 rs56256440 chr10:79698207 A/G cg17075019 chr10:79541650 NA -0.65 -12.26 -0.44 3.56e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs698761 0.505 rs7609180 chr2:44538484 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 7.85 0.3 1.74e-14 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs1801251 0.964 rs13007783 chr2:233566679 G/A cg08000102 chr2:233561755 GIGYF2 0.62 13.69 0.48 1.36e-37 Coronary artery disease; BRCA cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg18230493 chr5:56204884 C5orf35 -0.91 -17.93 -0.58 1.55e-58 Initial pursuit acceleration; BRCA cis rs2882667 0.838 rs11958529 chr5:138395068 C/T cg04439458 chr5:138467593 SIL1 -0.33 -8.91 -0.33 5.29e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg03354898 chr7:1950403 MAD1L1 -0.44 -8.94 -0.33 4.19e-18 Bipolar disorder and schizophrenia; BRCA cis rs921968 0.541 rs58650092 chr2:219304851 C/A cg02176678 chr2:219576539 TTLL4 -0.44 -11.56 -0.42 3.44e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.62e-22 Bladder cancer; BRCA cis rs2762353 0.574 rs9467573 chr6:25704190 C/A cg03517284 chr6:25882590 NA 0.68 15.32 0.52 2.44e-45 Blood metabolite levels; BRCA cis rs739401 0.572 rs389285 chr11:3062673 G/A cg05729581 chr11:3078854 CARS -0.34 -8.18 -0.31 1.5e-15 Longevity; BRCA cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg06618935 chr21:46677482 NA -0.36 -7.99 -0.3 6.31e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.22 -0.44 5.2e-31 Gut microbiome composition (summer); BRCA cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg06046430 chr4:77819534 ANKRD56 0.59 13.27 0.46 1.13e-35 Emphysema distribution in smoking; BRCA cis rs4478858 0.684 rs10753245 chr1:31731208 A/G cg00250761 chr1:31883323 NA -0.33 -8.64 -0.32 4.66e-17 Alcohol dependence; BRCA cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg08601574 chr20:25228251 PYGB -0.39 -9.0 -0.34 2.47e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg18479299 chr3:125709523 NA -0.53 -8.33 -0.31 5.07e-16 Blood pressure (smoking interaction); BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs7178424 0.870 rs12898423 chr15:62251451 T/C cg00456672 chr15:62358751 C2CD4A 0.43 9.78 0.36 3.78e-21 Height; BRCA cis rs7246967 0.673 rs35731237 chr19:22820510 G/T cg23217946 chr19:22817039 ZNF492 0.47 8.48 0.32 1.56e-16 Bronchopulmonary dysplasia; BRCA cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg04518342 chr5:131593106 PDLIM4 0.38 8.78 0.33 1.48e-17 Acylcarnitine levels; BRCA cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg15432903 chr11:17409602 KCNJ11 0.71 15.93 0.53 2.28e-48 Type 2 diabetes; BRCA cis rs10927875 0.722 rs1763605 chr1:16338925 T/G cg22431228 chr1:16359049 CLCNKA -0.45 -9.2 -0.34 4.89e-19 Dilated cardiomyopathy; BRCA cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg23711669 chr6:146136114 FBXO30 -0.75 -17.43 -0.57 5.61e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.73 -0.55 2.24e-52 Axial length; BRCA cis rs1371614 0.611 rs7557229 chr2:27130891 T/C cg12368169 chr2:27073192 DPYSL5 -0.29 -8.66 -0.32 3.86e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6570726 0.935 rs12663211 chr6:145818427 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs9487051 0.676 rs9386774 chr6:109561646 C/T cg01475377 chr6:109611718 NA -0.37 -8.87 -0.33 7.04e-18 Reticulocyte fraction of red cells; BRCA cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.34 11.35 0.41 2.6e-27 Systemic lupus erythematosus; BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg22764044 chr5:178986830 RUFY1 0.39 10.14 0.37 1.67e-22 Lung cancer; BRCA trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg25214090 chr10:38739885 LOC399744 0.53 12.03 0.43 3.51e-30 Corneal astigmatism; BRCA cis rs6433895 1.000 rs56169464 chr2:182012828 A/C cg00481216 chr2:181971175 NA 0.37 8.54 0.32 9.6e-17 Lymphocyte counts; BRCA cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 10.98 0.4 8.41e-26 Rheumatoid arthritis; BRCA cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.04 0.34 1.86e-18 Lymphocyte counts; BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg26314531 chr2:26401878 FAM59B 0.96 16.36 0.54 1.59e-50 Gut microbiome composition (summer); BRCA cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg22508957 chr16:3507546 NAT15 0.46 11.3 0.41 3.97e-27 Tuberculosis; BRCA cis rs7927771 0.929 rs12787646 chr11:47669665 T/C cg18512352 chr11:47633146 NA -0.33 -8.09 -0.3 2.98e-15 Subjective well-being; BRCA cis rs62458065 0.640 rs10241303 chr7:32534203 T/G cg20159608 chr7:32802032 NA -0.46 -8.33 -0.31 5e-16 Metabolite levels (HVA/MHPG ratio); BRCA cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.82e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs6479891 0.778 rs10761735 chr10:65043918 A/G cg14819942 chr15:35414228 NA -0.35 -8.57 -0.32 7.85e-17 Arthritis (juvenile idiopathic); BRCA cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg23018236 chr17:30244563 NA -0.61 -10.02 -0.37 4.87e-22 Hip circumference adjusted for BMI; BRCA cis rs7103648 0.966 rs10838702 chr11:47410888 G/T cg20307385 chr11:47447363 PSMC3 0.77 21.99 0.66 2.96e-80 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs17253792 0.731 rs74823888 chr14:56049800 T/C cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.29e-20 Putamen volume; BRCA trans rs61931739 1.000 rs12305700 chr12:34036332 T/C cg26384229 chr12:38710491 ALG10B -0.42 -9.4 -0.35 9.36e-20 Morning vs. evening chronotype; BRCA cis rs11252926 0.545 rs1551508 chr10:555469 A/G cg03684893 chr10:554711 DIP2C -0.4 -9.95 -0.37 9.07e-22 Psychosis in Alzheimer's disease; BRCA cis rs11690935 0.571 rs1008151 chr2:172912098 G/A cg13550731 chr2:172543902 DYNC1I2 0.59 14.78 0.5 9.94e-43 Schizophrenia; BRCA cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg13010199 chr12:38710504 ALG10B -0.37 -8.87 -0.33 7.5e-18 Morning vs. evening chronotype; BRCA cis rs9858542 0.953 rs9811982 chr3:49624377 A/C cg03060546 chr3:49711283 APEH -0.56 -11.48 -0.41 7.03e-28 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg13256891 chr4:100009986 ADH5 -0.52 -9.64 -0.36 1.27e-20 Alcohol dependence; BRCA cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg03517284 chr6:25882590 NA -0.48 -9.81 -0.36 2.95e-21 Intelligence (multi-trait analysis); BRCA cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg22906224 chr7:99728672 NA 0.43 8.23 0.31 1.04e-15 Coronary artery disease; BRCA cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg24531977 chr5:56204891 C5orf35 -0.72 -16.11 -0.54 2.79e-49 Initial pursuit acceleration; BRCA trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21659725 chr3:3221576 CRBN -0.71 -21.67 -0.65 1.76e-78 Intelligence (multi-trait analysis); BRCA cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg27446573 chr6:127587934 RNF146 0.9 21.16 0.64 9.91e-76 Breast cancer; BRCA cis rs72766638 0.895 rs72766630 chr9:136926791 G/T cg13789015 chr9:136890014 NCRNA00094 0.54 8.28 0.31 7.34e-16 Mosquito bite size; BRCA cis rs7666738 0.688 rs35739409 chr4:98576934 C/T cg05340658 chr4:99064831 C4orf37 0.52 8.39 0.32 3.12e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.8 0.39 4.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1994135 0.669 rs11052747 chr12:33697913 C/G cg06521331 chr12:34319734 NA -0.46 -8.9 -0.33 5.68e-18 Resting heart rate; BRCA cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg10169327 chr19:45448959 APOC2 -0.33 -8.09 -0.3 3.05e-15 Blood protein levels; BRCA cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.68 0.42 1.03e-28 Homoarginine levels; BRCA cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg21724239 chr8:58056113 NA 0.43 7.82 0.3 2.18e-14 Developmental language disorder (linguistic errors); BRCA cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg10802521 chr3:52805072 NEK4 -0.34 -9.41 -0.35 8.52e-20 Electroencephalogram traits; BRCA cis rs908922 0.676 rs528427 chr1:152511507 G/C cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg06453172 chr10:134556979 INPP5A -0.53 -11.31 -0.41 3.57e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs8032158 1.000 rs7162435 chr15:56121334 C/T cg02198044 chr15:56286336 NEDD4 0.36 8.82 0.33 1.06e-17 Keloid; BRCA cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 11.3 0.41 4.01e-27 Personality dimensions; BRCA cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg08807101 chr21:30365312 RNF160 -0.6 -14.84 -0.51 4.91e-43 Dental caries; BRCA trans rs11098499 0.954 rs3890049 chr4:120326283 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.14 0.31 2.04e-15 Corneal astigmatism; BRCA cis rs1580019 0.563 rs34201720 chr7:32568935 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.7 0.76 1.84e-122 Cognitive ability; BRCA cis rs34891900 0.507 rs12167771 chr22:18124332 G/A cg19898043 chr22:18121309 BCL2L13 0.46 9.24 0.34 3.75e-19 Sum neutrophil eosinophil counts; BRCA cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg13010199 chr12:38710504 ALG10B 0.52 10.56 0.39 3.91e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs1577917 1.000 rs12663690 chr6:86640162 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.31 7.81 0.3 2.41e-14 Response to antipsychotic treatment; BRCA cis rs11098499 0.657 rs71614442 chr4:120379346 C/T cg09307838 chr4:120376055 NA 0.75 16.18 0.54 1.37e-49 Corneal astigmatism; BRCA cis rs7647973 1.000 rs6446262 chr3:49401153 T/C cg07636037 chr3:49044803 WDR6 0.77 15.46 0.52 4.7e-46 Menarche (age at onset); BRCA cis rs4363385 0.818 rs574649 chr1:153008471 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs4285028 0.848 rs4118376 chr3:121636450 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.63 -11.11 -0.4 2.34e-26 Multiple sclerosis; BRCA cis rs1538970 0.924 rs11211118 chr1:45930270 A/C cg05343316 chr1:45956843 TESK2 0.64 13.16 0.46 3.46e-35 Platelet count; BRCA cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.5 11.63 0.42 1.77e-28 Multiple sclerosis; BRCA cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.19 -0.31 1.41e-15 Aortic root size; BRCA cis rs2011503 0.941 rs11555053 chr19:19390185 G/A cg11584989 chr19:19387371 SF4 0.6 13.54 0.47 6.94e-37 Bipolar disorder; BRCA cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.24 0.49 3.5e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2304069 0.954 rs1469691 chr5:149386716 G/A cg12661370 chr5:149340060 SLC26A2 0.56 8.27 0.31 8.04e-16 HIV-1 control; BRCA cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg22862634 chr11:62369728 EML3;MTA2 0.55 13.65 0.48 2.07e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs853679 0.607 rs28360499 chr6:27945396 G/A cg01620082 chr3:125678407 NA -0.98 -11.11 -0.4 2.38e-26 Depression; BRCA cis rs11031096 0.502 rs720571 chr11:4001328 G/T cg18678763 chr11:4115507 RRM1 -0.35 -7.96 -0.3 8.16e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg23033748 chr14:75592666 NEK9 -0.39 -9.42 -0.35 7.86e-20 Height; BRCA cis rs10911251 0.546 rs1547715 chr1:183113952 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA cis rs208520 0.690 rs1304672 chr6:66847973 A/G cg07460842 chr6:66804631 NA 0.98 18.01 0.58 6.12e-59 Exhaled nitric oxide output; BRCA cis rs9300255 0.602 rs2695479 chr12:123689386 T/C cg00376283 chr12:123451042 ABCB9 0.52 10.22 0.37 8.49e-23 Neutrophil percentage of white cells; BRCA cis rs7927771 0.864 rs755554 chr11:47432034 G/C cg20307385 chr11:47447363 PSMC3 0.41 9.0 0.34 2.5e-18 Subjective well-being; BRCA trans rs1325195 0.881 rs10913690 chr1:179067071 G/T cg11624085 chr17:8464688 MYH10 -0.25 -7.96 -0.3 7.88e-15 IgE grass sensitization; BRCA cis rs36051895 0.632 rs1590803 chr9:5177533 T/C cg02405213 chr9:5042618 JAK2 -0.47 -9.06 -0.34 1.52e-18 Pediatric autoimmune diseases; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg18279126 chr7:2041391 MAD1L1 0.39 8.64 0.32 4.47e-17 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.51 -0.32 1.19e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7264396 0.563 rs6060566 chr20:34288226 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.12 -0.43 1.38e-30 Total cholesterol levels; BRCA cis rs1801251 0.963 rs66549961 chr2:233602293 A/G cg08000102 chr2:233561755 GIGYF2 0.64 14.01 0.48 4.39e-39 Coronary artery disease; BRCA cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg24324837 chr19:49891574 CCDC155 0.47 8.12 0.31 2.47e-15 Multiple sclerosis; BRCA cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg06636001 chr8:8085503 FLJ10661 0.55 11.92 0.43 1.03e-29 Mood instability; BRCA cis rs6840360 0.593 rs10022023 chr4:152560731 A/G cg22705602 chr4:152727874 NA -0.32 -8.43 -0.32 2.28e-16 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.517 rs11052977 chr12:34035030 A/C cg13010199 chr12:38710504 ALG10B 0.5 9.53 0.35 3.31e-20 Morning vs. evening chronotype; BRCA cis rs7633857 0.512 rs7611005 chr3:160698549 A/T cg03342759 chr3:160939853 NMD3 -0.54 -11.38 -0.41 1.98e-27 Educational attainment (years of education); BRCA cis rs7258465 0.931 rs271629 chr19:18623198 G/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.48 -0.32 1.6e-16 Breast cancer; BRCA cis rs6495367 1.000 rs1007366 chr15:79379541 G/A cg17916960 chr15:79447300 NA 0.34 8.13 0.31 2.2e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2243480 0.711 rs2460426 chr7:65623129 A/G cg18252515 chr7:66147081 NA 1.02 15.12 0.51 2.32e-44 Diabetic kidney disease; BRCA cis rs10465746 0.967 rs1475263 chr1:84339497 A/T cg10977910 chr1:84465055 TTLL7 0.51 10.28 0.38 4.89e-23 Obesity-related traits; BRCA cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg12386194 chr3:101231763 SENP7 0.45 9.65 0.36 1.12e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs796364 1.000 rs281763 chr2:200794870 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.68 11.5 0.41 6.24e-28 Schizophrenia; BRCA cis rs56399783 0.901 rs17132624 chr7:2778496 G/A cg19731401 chr7:2775893 GNA12 0.51 8.16 0.31 1.76e-15 Childhood ear infection; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg00814883 chr7:100076585 TSC22D4 -0.55 -10.83 -0.39 3.35e-25 Platelet count; BRCA cis rs1568889 0.838 rs11030185 chr11:28041904 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.33 0.63 2.95e-71 Bipolar disorder; BRCA cis rs4423214 0.559 rs10898201 chr11:71201527 C/A cg05163923 chr11:71159392 DHCR7 -0.5 -8.83 -0.33 1.04e-17 Vitamin D levels; BRCA cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg03709012 chr19:19516395 GATAD2A 0.73 16.19 0.54 1.16e-49 Tonsillectomy; BRCA cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg04518342 chr5:131593106 PDLIM4 0.35 8.57 0.32 7.69e-17 Blood metabolite levels; BRCA cis rs10746514 0.804 rs11122429 chr1:232261532 G/A cg09506761 chr1:232265262 NA -0.41 -8.36 -0.31 4e-16 Response to statin therapy; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg23708337 chr7:1209742 NA 0.64 8.94 0.33 4.31e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7249921 0.833 rs62111373 chr19:35660844 G/C cg15419183 chr19:35660584 FXYD5 0.45 10.25 0.38 6.37e-23 Platelet count; BRCA cis rs4363385 0.510 rs7532166 chr1:153046851 C/G cg25856811 chr1:152973957 SPRR3 -0.32 -7.83 -0.3 2.11e-14 Inflammatory skin disease; BRCA cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg12011299 chr4:100065546 ADH4 0.51 11.77 0.42 4.27e-29 Alcohol dependence; BRCA trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg00717180 chr2:96193071 NA 0.3 8.25 0.31 8.85e-16 Coronary artery disease; BRCA cis rs365132 0.517 rs7706790 chr5:176359136 C/T cg16309518 chr5:176445507 NA -0.43 -9.91 -0.36 1.25e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg15242686 chr22:24348715 GSTTP1 -0.51 -13.03 -0.46 1.4e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7575217 0.767 rs6543018 chr2:101730288 A/G cg23907051 chr2:101730305 TBC1D8 0.2 7.82 0.3 2.23e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.8e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs11722228 0.508 rs61335146 chr4:10130793 G/C cg26043149 chr18:55253948 FECH 0.99 23.46 0.68 2.99e-88 Gout;Urate levels;Serum uric acid levels; BRCA cis rs6908034 0.607 rs76413455 chr6:19808964 T/G cg02682789 chr6:19804855 NA 0.75 8.8 0.33 1.25e-17 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; BRCA cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.33 0.38 3.11e-23 Bipolar disorder; BRCA cis rs950169 0.519 rs7237 chr15:85186577 C/T cg17507749 chr15:85114479 UBE2QP1 0.53 9.83 0.36 2.41e-21 Schizophrenia; BRCA cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg23992470 chr4:843637 GAK 0.57 8.44 0.32 2.2e-16 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg23711669 chr6:146136114 FBXO30 0.71 14.58 0.5 8.61e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2580764 0.565 rs7562292 chr2:55230219 C/T cg09592903 chr2:55203963 RTN4 -0.4 -10.3 -0.38 4.13e-23 Mean platelet volume; BRCA cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg16339924 chr4:17578868 LAP3 0.57 14.0 0.48 4.74e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg11845111 chr2:191398756 TMEM194B 0.79 14.79 0.5 9.06e-43 Diastolic blood pressure; BRCA cis rs13102973 0.640 rs13140829 chr4:135838818 T/C cg14419869 chr4:135874104 NA 0.45 9.09 0.34 1.24e-18 Subjective well-being; BRCA trans rs11098499 0.820 rs6534140 chr4:120455311 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs858239 0.539 rs10254544 chr7:23220235 T/C cg23682824 chr7:23144976 KLHL7 0.35 9.12 0.34 9.91e-19 Cerebrospinal fluid biomarker levels; BRCA cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg06115741 chr20:33292138 TP53INP2 -0.4 -8.75 -0.33 1.86e-17 Glomerular filtration rate (creatinine); BRCA trans rs911555 0.755 rs2756135 chr14:103962579 G/A cg17675199 chr6:35436792 RPL10A -0.3 -8.14 -0.31 2e-15 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4237845 0.537 rs7969844 chr12:58278271 C/T cg00677455 chr12:58241039 CTDSP2 0.64 15.92 0.53 2.54e-48 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.929 rs10844740 chr12:34067930 C/T cg26384229 chr12:38710491 ALG10B -0.42 -10.04 -0.37 4.1e-22 Morning vs. evening chronotype; BRCA cis rs3806933 0.522 rs17553936 chr5:110454681 A/G cg04022379 chr5:110408740 TSLP 0.47 10.07 0.37 3.04e-22 Eosinophilic esophagitis; BRCA cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg00990874 chr7:1149470 C7orf50 0.52 10.17 0.37 1.33e-22 Bronchopulmonary dysplasia; BRCA cis rs67478160 0.506 rs6575998 chr14:104250417 A/G cg01849466 chr14:104193079 ZFYVE21 -0.48 -12.44 -0.44 6.03e-32 Schizophrenia; BRCA trans rs61931739 0.517 rs10844802 chr12:34231001 C/A cg26384229 chr12:38710491 ALG10B 0.67 14.35 0.49 1.15e-40 Morning vs. evening chronotype; BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg01262667 chr19:19385393 TM6SF2 -0.4 -10.33 -0.38 3.1e-23 Tonsillectomy; BRCA cis rs11190604 1.000 rs10786597 chr10:102291287 C/T cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs478304 0.934 rs1193496 chr11:65537556 C/T cg08755490 chr11:65554678 OVOL1 -0.53 -11.18 -0.4 1.29e-26 Acne (severe); BRCA cis rs1003719 0.680 rs2835670 chr21:38581114 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.51 -0.5 1.83e-41 Eye color traits; BRCA cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.22e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1790761 0.692 rs10896179 chr11:67316928 C/A cg00290607 chr11:67383545 NA 0.42 9.36 0.35 1.29e-19 Mean corpuscular volume; BRCA cis rs867371 1.000 rs6495643 chr15:82479254 C/G cg00614314 chr15:82944287 LOC80154 0.43 9.06 0.34 1.52e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg26384229 chr12:38710491 ALG10B 0.85 22.89 0.67 3.77e-85 Heart rate; BRCA cis rs6782228 0.509 rs2811495 chr3:128359957 A/G cg16766828 chr3:128327626 NA -0.42 -9.51 -0.35 3.94e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7267979 1.000 rs2257420 chr20:25275890 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.25e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.56 -0.44 1.79e-32 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg16606324 chr3:10149918 C3orf24 0.52 10.19 0.37 1.1e-22 Alzheimer's disease; BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg14004847 chr7:1930337 MAD1L1 -0.41 -8.64 -0.32 4.66e-17 Bipolar disorder and schizophrenia; BRCA cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.07 16.3 0.54 3.19e-50 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12579753 0.917 rs4842410 chr12:82219225 A/T cg07988820 chr12:82153109 PPFIA2 -0.5 -8.69 -0.33 3.01e-17 Resting heart rate; BRCA cis rs6142102 0.923 rs6059586 chr20:32540501 G/A cg24642439 chr20:33292090 TP53INP2 0.43 8.37 0.31 3.76e-16 Skin pigmentation; BRCA cis rs2304069 0.954 rs4705409 chr5:149414899 A/G cg10852222 chr5:149380144 HMGXB3;TIGD6 0.53 8.54 0.32 9.47e-17 HIV-1 control; BRCA cis rs11098499 0.675 rs11098534 chr4:120556772 T/G cg09307838 chr4:120376055 NA 0.59 12.36 0.44 1.22e-31 Corneal astigmatism; BRCA cis rs9811920 0.625 rs9290003 chr3:99906993 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 8.78 0.33 1.53e-17 Axial length; BRCA cis rs6723226 0.806 rs6543658 chr2:32718849 G/A cg02381751 chr2:32503542 YIPF4 0.7 15.59 0.53 1.08e-46 Intelligence (multi-trait analysis); BRCA cis rs738321 0.725 rs9622738 chr22:38542346 G/A cg20207973 chr22:38506712 BAIAP2L2 0.41 9.7 0.36 7.51e-21 Breast cancer; BRCA cis rs17741873 0.779 rs10458656 chr10:75592662 A/G cg07699608 chr10:75541558 CHCHD1 0.51 8.1 0.31 2.86e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs12760731 0.565 rs116253445 chr1:178216962 C/T cg00404053 chr1:178313656 RASAL2 0.65 7.92 0.3 1.09e-14 Obesity-related traits; BRCA cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.83 -0.36 2.47e-21 Tonsillectomy; BRCA cis rs35306767 0.855 rs12770190 chr10:951262 C/T cg26597838 chr10:835615 NA 1.02 17.18 0.56 1.08e-54 Eosinophil percentage of granulocytes; BRCA cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg27624424 chr6:160112604 SOD2 0.4 8.2 0.31 1.36e-15 Age-related macular degeneration (geographic atrophy); BRCA cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg05340658 chr4:99064831 C4orf37 -0.69 -17.51 -0.57 2.27e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9389248 0.500 rs116273677 chr6:135339135 A/C cg24558204 chr6:135376177 HBS1L 0.46 12.59 0.45 1.31e-32 High light scatter reticulocyte percentage of red cells; BRCA cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg26384229 chr12:38710491 ALG10B 0.77 18.03 0.58 4.4e-59 Drug-induced liver injury (flucloxacillin); BRCA cis rs798766 1.000 rs7682402 chr4:1743343 G/A cg10756475 chr4:1757242 NA 0.38 8.59 0.32 6.73e-17 Bladder cancer;Urinary bladder cancer; BRCA cis rs440932 1.000 rs365309 chr8:9026940 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -8.49 -0.32 1.43e-16 High light scatter reticulocyte percentage of red cells; BRCA cis rs8062405 0.964 rs11860513 chr16:28825420 C/T cg09754948 chr16:28834200 ATXN2L 0.45 8.86 0.33 7.7e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg10729496 chr3:10149963 C3orf24 -0.44 -8.55 -0.32 9.38e-17 Alzheimer's disease; BRCA cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg02503808 chr4:7069936 GRPEL1 0.78 17.54 0.57 1.69e-56 Monocyte percentage of white cells; BRCA cis rs9527 0.615 rs11191485 chr10:104729816 G/C cg04362960 chr10:104952993 NT5C2 0.46 10.65 0.39 1.71e-24 Arsenic metabolism; BRCA cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg11812906 chr14:75593930 NEK9 -0.7 -16.19 -0.54 1.19e-49 Height; BRCA cis rs858239 0.601 rs6962526 chr7:23158233 G/A cg23682824 chr7:23144976 KLHL7 0.42 11.09 0.4 2.96e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg01579765 chr21:45077557 HSF2BP -0.39 -10.23 -0.38 7.5e-23 Mean corpuscular volume; BRCA cis rs35146811 0.659 rs863450 chr7:99821685 C/T cg13334819 chr7:99746414 C7orf59 0.39 9.01 0.34 2.32e-18 Coronary artery disease; BRCA cis rs7737355 0.947 rs79018835 chr5:130798461 C/A cg06307176 chr5:131281290 NA -0.53 -10.51 -0.38 6.05e-24 Life satisfaction; BRCA trans rs11722228 0.521 rs62288520 chr4:10099674 G/A cg26043149 chr18:55253948 FECH 1.08 23.32 0.68 1.71e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg19723775 chr5:179050963 HNRNPH1 -0.35 -8.34 -0.31 4.45e-16 Lung cancer; BRCA cis rs2599510 0.783 rs2710630 chr2:32765997 A/C cg02381751 chr2:32503542 YIPF4 -0.43 -8.48 -0.32 1.51e-16 Interleukin-18 levels; BRCA cis rs17095355 1.000 rs72828232 chr10:111725298 C/T cg00817464 chr10:111662876 XPNPEP1 -0.44 -9.48 -0.35 4.86e-20 Biliary atresia; BRCA cis rs9399135 0.816 rs4134030 chr6:135354094 G/T cg24558204 chr6:135376177 HBS1L 0.44 12.07 0.43 2.37e-30 Red blood cell count; BRCA cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg10560079 chr2:191398806 TMEM194B 0.4 8.69 0.32 3.15e-17 Pulse pressure; BRCA cis rs9790314 0.586 rs67077657 chr3:161138521 A/G cg03342759 chr3:160939853 NMD3 -0.63 -13.74 -0.48 7.99e-38 Morning vs. evening chronotype; BRCA cis rs11098499 1.000 rs12506395 chr4:120185094 C/T cg09307838 chr4:120376055 NA 0.61 12.35 0.44 1.44e-31 Corneal astigmatism; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg04450456 chr4:17643702 FAM184B 0.36 10.63 0.39 2.04e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs35110281 0.626 rs10854486 chr21:45118280 G/T cg04455712 chr21:45112962 RRP1B 0.41 10.6 0.39 2.69e-24 Mean corpuscular volume; BRCA cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg07636037 chr3:49044803 WDR6 0.69 17.04 0.56 6.17e-54 Menarche (age at onset); BRCA trans rs17685 0.587 rs1623759 chr7:75724679 A/T cg19862616 chr7:65841803 NCRNA00174 0.85 27.75 0.74 7.88e-112 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6987853 0.761 rs2923391 chr8:42415942 G/A cg09913449 chr8:42400586 C8orf40 0.42 9.38 0.35 1.11e-19 Mean corpuscular hemoglobin concentration; BRCA trans rs1941687 0.509 rs2282632 chr18:31320229 A/G cg15819921 chr19:927150 ARID3A -0.41 -7.87 -0.3 1.57e-14 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs754466 0.580 rs10762765 chr10:79566407 T/C cg17075019 chr10:79541650 NA -0.76 -18.77 -0.6 5.94e-63 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7523273 0.606 rs7144 chr1:207967719 A/G cg22525895 chr1:207977042 MIR29B2 -0.49 -12.3 -0.44 2.44e-31 Schizophrenia; BRCA trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg25517755 chr10:38738941 LOC399744 -0.37 -7.87 -0.3 1.53e-14 Corneal astigmatism; BRCA cis rs3008870 0.755 rs1024230 chr1:67512920 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.58 12.38 0.44 1.07e-31 Lymphocyte percentage of white cells; BRCA cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs9325144 0.555 rs12424003 chr12:38688140 C/T cg13010199 chr12:38710504 ALG10B -0.38 -8.53 -0.32 1.06e-16 Morning vs. evening chronotype; BRCA cis rs9581857 0.685 rs9319372 chr13:28042796 C/T cg22138327 chr13:27999177 GTF3A -0.63 -9.84 -0.36 2.29e-21 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); BRCA cis rs9486719 0.948 rs11152953 chr6:96894305 C/T cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs4409675 0.576 rs11247705 chr1:28212272 G/A cg23691781 chr1:28212827 C1orf38 0.33 11.03 0.4 5.38e-26 Corneal astigmatism; BRCA cis rs7264396 0.790 rs6060539 chr20:34239382 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.05 0.3 3.95e-15 Total cholesterol levels; BRCA cis rs1863824 0.625 rs11202024 chr10:88168024 C/A cg07322936 chr10:88137208 NA -0.45 -8.85 -0.33 8.25e-18 Schizophrenia; BRCA cis rs7246657 0.525 rs997516 chr19:37474264 T/C cg23950597 chr19:37808831 NA -0.6 -9.41 -0.35 8.83e-20 Coronary artery calcification; BRCA cis rs600806 0.850 rs10745354 chr1:109931908 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs698833 0.819 rs1372078 chr2:44543389 A/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.48 -9.7 -0.36 7.88e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.77 0.39 5.63e-25 Bipolar disorder; BRCA cis rs13095912 0.819 rs11918734 chr3:185296602 T/C cg11274856 chr3:185301563 NA 0.54 12.87 0.45 7.58e-34 Systolic blood pressure; BRCA cis rs5758659 0.504 rs133367 chr22:42463366 A/G cg15557168 chr22:42548783 NA 0.33 9.33 0.35 1.67e-19 Cognitive function; BRCA cis rs637571 0.546 rs11227311 chr11:65585257 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -8.89 -0.33 5.97e-18 Eosinophil percentage of white cells; BRCA cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.58 12.74 0.45 2.75e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg13010199 chr12:38710504 ALG10B 0.41 8.37 0.31 3.59e-16 Bladder cancer; BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs300703 0.816 rs449725 chr2:202993 C/G cg21211680 chr2:198530 NA -0.45 -7.88 -0.3 1.4e-14 Blood protein levels; BRCA cis rs7520050 0.966 rs7550746 chr1:46351719 T/A cg24296786 chr1:45957014 TESK2 0.44 9.81 0.36 3.08e-21 Red blood cell count;Reticulocyte count; BRCA cis rs1595825 0.891 rs59938443 chr2:198497105 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -8.1 -0.31 2.76e-15 Ulcerative colitis; BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg13628971 chr7:2884303 GNA12 0.58 11.93 0.43 9.27e-30 Height; BRCA cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg21395723 chr22:39101663 GTPBP1 0.4 8.67 0.32 3.55e-17 Menopause (age at onset); BRCA cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg13271783 chr10:134563150 INPP5A -0.44 -9.18 -0.34 6.01e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs76419734 0.510 rs2553463 chr4:106730663 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.44 -9.59 -0.35 1.96e-20 Post bronchodilator FEV1; BRCA cis rs116095464 0.558 rs10056628 chr5:279512 G/A cg22857025 chr5:266934 NA -1.03 -19.86 -0.62 9.84e-69 Breast cancer; BRCA cis rs1577917 1.000 rs12212733 chr6:86726013 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -12.81 -0.45 1.31e-33 Response to antipsychotic treatment; BRCA cis rs6815814 0.950 rs67719080 chr4:38787252 A/G cg06935464 chr4:38784597 TLR10 0.51 9.57 0.35 2.32e-20 Breast cancer; BRCA cis rs733592 0.504 rs2261608 chr12:48721634 A/T cg24011408 chr12:48396354 COL2A1 0.41 8.31 0.31 5.55e-16 Plateletcrit; BRCA cis rs9457247 1.000 rs422562 chr6:167406318 A/G cg00271210 chr6:167070053 RPS6KA2 -0.34 -8.88 -0.33 6.85e-18 Crohn's disease; BRCA cis rs10864907 0.614 rs12711745 chr2:113700355 T/C cg12858261 chr2:113808755 IL1F8 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg08132940 chr7:1081526 C7orf50 -0.58 -8.7 -0.33 2.79e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9517320 0.515 rs9556972 chr13:99209815 C/T cg07423050 chr13:99094983 FARP1 -0.45 -10.22 -0.37 8.3e-23 Longevity; BRCA cis rs13136331 0.680 rs2732178 chr4:88654589 T/C cg22416721 chr4:88570574 DMP1 -0.57 -13.56 -0.47 5.42e-37 Sitting height ratio; BRCA trans rs9858542 0.953 rs9837027 chr3:49597013 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.53 -0.35 3.21e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9287719 0.614 rs10929680 chr2:10723126 C/T cg00105475 chr2:10696890 NA 0.41 9.12 0.34 9.77e-19 Prostate cancer; BRCA cis rs3824867 1.000 rs3824867 chr11:47468569 A/G cg20307385 chr11:47447363 PSMC3 0.55 12.1 0.43 1.7e-30 Mean corpuscular hemoglobin; BRCA cis rs7100689 0.646 rs10788562 chr10:82072310 C/T cg01528321 chr10:82214614 TSPAN14 -0.8 -16.83 -0.55 7.17e-53 Post bronchodilator FEV1; BRCA cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg08999081 chr20:33150536 PIGU 0.34 8.83 0.33 9.78e-18 Coronary artery disease; BRCA cis rs6460942 0.597 rs17448193 chr7:12525641 G/A cg06484146 chr7:12443880 VWDE -0.58 -7.8 -0.3 2.45e-14 Coronary artery disease; BRCA cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.85 0.39 2.81e-25 Rheumatoid arthritis; BRCA cis rs514406 0.621 rs881198 chr1:53196440 C/T cg16325326 chr1:53192061 ZYG11B -0.85 -23.15 -0.68 1.4e-86 Monocyte count; BRCA cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.27 0.38 5.19e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs3733585 0.673 rs9994937 chr4:9964799 G/T cg26043149 chr18:55253948 FECH -0.37 -8.22 -0.31 1.17e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11585357 0.895 rs4625336 chr1:17630964 G/T cg19159961 chr1:17633534 PADI4 0.55 9.43 0.35 7.22e-20 Hair shape; BRCA cis rs7617773 0.963 rs12493256 chr3:48176747 C/T cg11946769 chr3:48343235 NME6 -0.39 -8.43 -0.32 2.33e-16 Coronary artery disease; BRCA cis rs644148 0.967 rs2686778 chr19:44972257 G/A cg15540054 chr19:45004280 ZNF180 -0.57 -12.12 -0.43 1.37e-30 Personality dimensions; BRCA cis rs7119 0.717 rs34981488 chr15:77723403 T/G cg17802220 chr15:77601643 NA -0.47 -10.27 -0.38 5.3e-23 Type 2 diabetes; BRCA cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg03146154 chr1:46216737 IPP 0.53 11.73 0.42 6.59e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg10523679 chr1:76189770 ACADM 0.71 12.35 0.44 1.38e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.78 -0.53 1.24e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.0 0.48 4.83e-39 Motion sickness; BRCA cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg04450456 chr4:17643702 FAM184B 0.34 9.66 0.36 1.04e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg11301795 chr4:187892539 NA 0.29 9.84 0.36 2.35e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs838147 0.815 rs28400015 chr19:49250633 G/A cg03531100 chr19:49260119 FGF21;FUT1 -0.37 -8.21 -0.31 1.19e-15 Dietary macronutrient intake; BRCA cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg12564285 chr5:131593104 PDLIM4 0.35 7.9 0.3 1.19e-14 Breast cancer; BRCA cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg02574844 chr11:5959923 NA -0.42 -8.73 -0.33 2.22e-17 DNA methylation (variation); BRCA cis rs11122272 0.735 rs2437149 chr1:231490105 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -11.55 -0.42 3.79e-28 Hemoglobin concentration; BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg14196790 chr5:131705035 SLC22A5 0.33 8.66 0.32 3.86e-17 Breast cancer; BRCA cis rs2130392 0.926 rs4610379 chr4:185624388 A/G cg21366198 chr4:185655624 MLF1IP -0.4 -9.76 -0.36 4.36e-21 Kawasaki disease; BRCA cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg23625390 chr15:77176239 SCAPER 0.39 9.04 0.34 1.9e-18 Blood metabolite levels; BRCA cis rs10791323 0.569 rs2298738 chr11:133715153 G/C cg06766960 chr11:133703094 NA -0.64 -13.42 -0.47 2.26e-36 Childhood ear infection; BRCA cis rs9400271 0.527 rs57749539 chr6:109640667 T/C cg01475377 chr6:109611718 NA 0.36 7.96 0.3 7.97e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs6121246 0.559 rs6060857 chr20:30300222 A/G cg13852791 chr20:30311386 BCL2L1 0.96 23.38 0.68 7.83e-88 Mean corpuscular hemoglobin; BRCA cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13136331 0.721 rs2627714 chr4:88687693 C/T cg22416721 chr4:88570574 DMP1 -0.51 -11.8 -0.42 3.33e-29 Sitting height ratio; BRCA cis rs881375 0.678 rs2269060 chr9:123683569 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.39 8.44 0.32 2.12e-16 Rheumatoid arthritis; BRCA cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg02475777 chr4:1388615 CRIPAK 0.4 8.69 0.33 3.06e-17 Longevity; BRCA cis rs7927592 0.956 rs7104877 chr11:68377602 G/T cg20283391 chr11:68216788 NA 0.44 9.35 0.35 1.43e-19 Total body bone mineral density; BRCA cis rs2180341 1.000 rs2180341 chr6:127600630 C/T cg27446573 chr6:127587934 RNF146 0.9 21.49 0.65 1.56e-77 Breast cancer; BRCA cis rs7914558 1.000 rs11191539 chr10:104819770 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.39 0.38 1.88e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7607369 0.609 rs13391398 chr2:219282429 A/G cg10223061 chr2:219282414 VIL1 -0.31 -9.21 -0.34 4.57e-19 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs3806843 1.000 rs3733707 chr5:140181892 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.86 -0.36 1.91e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18301423 chr5:131593218 PDLIM4 0.32 8.25 0.31 9.2e-16 Breast cancer; BRCA trans rs9291683 0.595 rs13150928 chr4:10052961 G/T cg26043149 chr18:55253948 FECH 0.46 9.79 0.36 3.65e-21 Bone mineral density; BRCA cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.875 rs1960885 chr6:146325930 G/T cg23711669 chr6:146136114 FBXO30 0.65 14.71 0.5 2.12e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg17971929 chr21:40555470 PSMG1 -0.5 -11.13 -0.4 2.07e-26 Menarche (age at onset); BRCA cis rs6714710 0.663 rs71429376 chr2:98534412 T/C cg26665480 chr2:98280029 ACTR1B 0.56 13.12 0.46 5.65e-35 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs9790314 1.000 rs336567 chr3:161073046 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.24 -0.49 3.58e-40 Morning vs. evening chronotype; BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg10729496 chr3:10149963 C3orf24 0.44 8.13 0.31 2.21e-15 Alzheimer's disease; BRCA cis rs11098499 0.954 rs12502423 chr4:120424172 A/C cg09307838 chr4:120376055 NA 0.73 15.57 0.52 1.36e-46 Corneal astigmatism; BRCA cis rs7520050 0.966 rs11211230 chr1:46406767 G/T cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.48e-21 Red blood cell count;Reticulocyte count; BRCA cis rs870825 0.616 rs4443323 chr4:185629805 C/A cg04058563 chr4:185651563 MLF1IP 0.86 16.4 0.54 1.05e-50 Blood protein levels; BRCA cis rs7786877 0.508 rs11765509 chr7:100310990 T/G cg16850897 chr7:100343110 ZAN -0.62 -13.11 -0.46 5.85e-35 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7829975 0.567 rs6601273 chr8:8796519 T/G cg15556689 chr8:8085844 FLJ10661 -0.41 -11.24 -0.41 7.02e-27 Mood instability; BRCA cis rs9467773 1.000 rs6922824 chr6:26553815 C/G cg11502198 chr6:26597334 ABT1 -0.47 -9.48 -0.35 4.94e-20 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.09 0.43 1.83e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs495337 0.736 rs2149278 chr20:48447153 A/G cg17835207 chr20:48524531 SPATA2 0.51 11.3 0.41 4.19e-27 Psoriasis; BRCA trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg15704280 chr7:45808275 SEPT13 -0.7 -14.25 -0.49 3.26e-40 Coronary artery disease; BRCA cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.43 9.09 0.34 1.24e-18 Cognitive ability; BRCA cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg04317338 chr11:64019027 PLCB3 0.58 9.99 0.37 6.17e-22 Mean platelet volume; BRCA cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.55 -0.39 4.43e-24 Menarche (age at onset); BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.88 0.6 1.57e-63 Tonsillectomy; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.31 -0.31 5.8e-16 Bipolar disorder and schizophrenia; BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg18758796 chr5:131593413 PDLIM4 0.37 8.62 0.32 5.1e-17 Acylcarnitine levels; BRCA cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg09658497 chr7:2847517 GNA12 -0.4 -8.48 -0.32 1.55e-16 Height; BRCA cis rs1210638 0.756 rs2518800 chr22:18973471 C/T cg06148736 chr22:18985691 NA -0.34 -8.79 -0.33 1.34e-17 Response to serotonin reuptake inhibitors in major depressive disorder; BRCA cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg16989086 chr20:62203971 PRIC285 0.53 8.84 0.33 9.3e-18 Glioblastoma; BRCA cis rs12760731 0.720 rs10913545 chr1:178360201 G/A cg00404053 chr1:178313656 RASAL2 0.62 8.26 0.31 8.55e-16 Obesity-related traits; BRCA cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg03146154 chr1:46216737 IPP 0.45 9.77 0.36 4.16e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.07 -0.56 4.11e-54 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.96e-15 Corneal astigmatism; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg00802000 chr16:706648 WDR90 -0.41 -9.52 -0.35 3.52e-20 Height; BRCA cis rs8077889 1.000 rs8077889 chr17:41878166 G/T cg26893861 chr17:41843967 DUSP3 -0.62 -11.9 -0.43 1.27e-29 Triglycerides; BRCA cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 7.15e-87 Chronic sinus infection; BRCA cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg00071950 chr4:10020882 SLC2A9 0.54 13.36 0.47 4.22e-36 Bone mineral density; BRCA cis rs4664304 0.802 rs1511224 chr2:160750861 C/T cg14819504 chr2:160761413 LY75 -0.33 -7.8 -0.3 2.44e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9790314 1.000 rs336585 chr3:161081670 A/G cg03342759 chr3:160939853 NMD3 -0.62 -13.32 -0.47 6.83e-36 Morning vs. evening chronotype; BRCA cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.71 -0.55 2.82e-52 Extrinsic epigenetic age acceleration; BRCA cis rs6545883 0.868 rs6748003 chr2:61806700 T/G cg15711740 chr2:61764176 XPO1 -0.57 -14.41 -0.5 5.58e-41 Tuberculosis; BRCA cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg26408565 chr15:76604113 ETFA -0.46 -10.0 -0.37 5.92e-22 Blood metabolite levels; BRCA cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg02574844 chr11:5959923 NA 0.45 9.99 0.37 5.95e-22 DNA methylation (variation); BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.27 -0.31 7.52e-16 Total body bone mineral density; BRCA cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg08392591 chr16:89556376 ANKRD11 -0.38 -9.13 -0.34 8.81e-19 Multiple myeloma (IgH translocation); BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.39e-15 Total body bone mineral density; BRCA cis rs2070997 0.607 rs2261468 chr9:133708873 T/C cg11464064 chr9:133710261 ABL1 0.51 9.49 0.35 4.48e-20 Response to amphetamines; BRCA cis rs8180040 1.000 rs1024037 chr3:47318449 C/A cg27129171 chr3:47204927 SETD2 -0.69 -16.61 -0.55 9.17e-52 Colorectal cancer; BRCA cis rs524281 0.861 rs10750779 chr11:65974591 C/G cg16950941 chr11:66035639 RAB1B -0.38 -8.11 -0.31 2.58e-15 Electroencephalogram traits; BRCA cis rs9392556 0.829 rs659025 chr6:4119051 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -8.0 -0.3 5.96e-15 Blood metabolite levels; BRCA cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.55 0.39 4.26e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs6793487 chr3:134299426 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.89 0.33 6.17e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.5e-34 Asthma (sex interaction); BRCA cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg03354898 chr7:1950403 MAD1L1 -0.47 -10.02 -0.37 4.88e-22 Bipolar disorder and schizophrenia; BRCA cis rs2072499 0.778 rs41265025 chr1:156163906 C/T cg24450063 chr1:156163899 SLC25A44 0.93 18.37 0.59 7.4e-61 Testicular germ cell tumor; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.0 -0.34 2.59e-18 Total body bone mineral density; BRCA cis rs9649465 0.561 rs603060 chr7:123427568 A/G cg03229431 chr7:123269106 ASB15 -0.43 -9.62 -0.36 1.48e-20 Migraine; BRCA cis rs9420 1.000 rs9420 chr11:57510294 A/G cg19752551 chr11:57585705 CTNND1 0.42 10.72 0.39 8.96e-25 Schizophrenia; BRCA cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg18252515 chr7:66147081 NA -0.56 -11.36 -0.41 2.27e-27 Corneal structure; BRCA cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg21545522 chr1:205238299 TMCC2 0.4 8.7 0.33 2.85e-17 Mean corpuscular volume;Mean platelet volume; BRCA cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg17971929 chr21:40555470 PSMG1 0.79 18.92 0.6 1.04e-63 Cognitive function; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg00106254 chr7:1943704 MAD1L1 -0.39 -9.5 -0.35 4.17e-20 Bipolar disorder and schizophrenia; BRCA cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs1499614 0.901 rs2178742 chr7:66197799 G/A cg18252515 chr7:66147081 NA -1.05 -15.41 -0.52 8.53e-46 Gout; BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.12 0.64 1.61e-75 Gut microbiome composition (summer); BRCA cis rs12791968 0.765 rs2279359 chr11:44999605 A/G cg11846598 chr11:44996168 LOC221122 0.45 8.35 0.31 4.15e-16 Inhibitory control; BRCA cis rs1505368 0.532 rs2888093 chr2:213328348 G/A cg20637307 chr2:213403960 ERBB4 0.51 12.01 0.43 4.07e-30 Symmetrical dimethylarginine levels; BRCA cis rs3799379 0.530 rs10456045 chr6:26404958 A/G cg09904177 chr6:26538194 HMGN4 0.36 8.5 0.32 1.39e-16 Intelligence (multi-trait analysis); BRCA cis rs9325144 0.647 rs35138700 chr12:38804474 C/T cg26384229 chr12:38710491 ALG10B -0.5 -11.93 -0.43 9.53e-30 Morning vs. evening chronotype; BRCA cis rs782590 0.935 rs6739513 chr2:55749902 G/A cg18811423 chr2:55921094 PNPT1 0.73 23.39 0.68 7.41e-88 Metabolic syndrome; BRCA cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.5 9.3 0.35 2.14e-19 Lung cancer in ever smokers; BRCA cis rs35110281 0.565 rs7278003 chr21:44966069 T/C cg01579765 chr21:45077557 HSF2BP -0.38 -9.96 -0.37 8.28e-22 Mean corpuscular volume; BRCA cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg08000102 chr2:233561755 GIGYF2 0.64 13.93 0.48 1.03e-38 Coronary artery disease; BRCA cis rs7647973 0.626 rs4855849 chr3:49653378 A/G cg07636037 chr3:49044803 WDR6 0.5 8.23 0.31 1.02e-15 Menarche (age at onset); BRCA cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.26 -0.34 3.02e-19 Colorectal cancer; BRCA cis rs10870270 1.000 rs11146354 chr10:133774757 A/G cg17892150 chr10:133769511 PPP2R2D -0.73 -15.52 -0.52 2.54e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11890956 chr21:40555474 PSMG1 -0.81 -19.44 -0.61 1.8e-66 Cognitive function; BRCA cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg18357645 chr12:58087776 OS9 0.42 11.96 0.43 6.97e-30 Celiac disease or Rheumatoid arthritis; BRCA trans rs2840044 1.000 rs9913003 chr17:33893904 C/A cg19694781 chr19:47549865 TMEM160 0.47 11.07 0.4 3.55e-26 Response to radiotherapy in cancer (late toxicity); BRCA cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg11812906 chr14:75593930 NEK9 0.56 12.76 0.45 2.14e-33 Height; BRCA cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg18230493 chr5:56204884 C5orf35 -0.73 -14.13 -0.49 1.17e-39 Initial pursuit acceleration; BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.61 9.41 0.35 8.56e-20 Renal function-related traits (BUN); BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg14062083 chr21:31802829 KRTAP13-4 0.36 9.81 0.36 2.86e-21 HDL cholesterol; BRCA cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.28 0.31 6.96e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6138458 1.000 rs11906373 chr20:24938832 A/G cg06937882 chr20:24974362 C20orf3 -0.47 -8.9 -0.33 5.59e-18 Blood protein levels; BRCA cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg18230493 chr5:56204884 C5orf35 0.62 13.04 0.46 1.3e-34 Initial pursuit acceleration; BRCA cis rs11051970 0.879 rs2651378 chr12:32581794 A/G cg24626660 chr12:32551988 NA 0.28 7.98 0.3 7.03e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg09526685 chr4:187126073 CYP4V2 1.0 12.21 0.44 5.49e-31 Blood protein levels; BRCA cis rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05901451 chr6:126070800 HEY2 0.45 11.01 0.4 6.04e-26 Endometrial cancer; BRCA cis rs2880765 0.835 rs6496027 chr15:86049988 C/T cg10818794 chr15:86012489 AKAP13 -0.31 -8.57 -0.32 8.05e-17 Coronary artery disease; BRCA cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg10224037 chr5:178157518 ZNF354A -0.75 -16.08 -0.54 4.24e-49 Neutrophil percentage of white cells; BRCA cis rs2835872 0.758 rs1709818 chr21:39036211 T/C cg06728970 chr21:39037746 KCNJ6 0.45 12.88 0.45 6.44e-34 Electroencephalographic traits in alcoholism; BRCA cis rs56104184 0.775 rs73063505 chr19:49402765 T/C cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg08917208 chr2:24149416 ATAD2B 0.87 12.43 0.44 6.24e-32 Lymphocyte counts; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg12444411 chr7:2802554 GNA12 -0.36 -8.62 -0.32 5.23e-17 Height; BRCA cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4780401 0.587 rs9931332 chr16:11807517 G/C cg01061890 chr16:11836724 TXNDC11 -0.55 -13.02 -0.46 1.49e-34 Rheumatoid arthritis; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg26314531 chr2:26401878 FAM59B 0.84 15.12 0.51 2.23e-44 Gut microbiome composition (summer); BRCA cis rs7818345 0.935 rs4633071 chr8:19275852 G/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.84 0.3 1.91e-14 Language performance in older adults (adjusted for episodic memory); BRCA cis rs694739 0.734 rs663743 chr11:64107735 G/A cg23796481 chr11:64053134 BAD;GPR137 0.51 9.82 0.36 2.8e-21 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs7666738 0.830 rs35685312 chr4:98858521 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA trans rs4714291 0.674 rs3008837 chr6:40046725 C/T cg02267698 chr19:7991119 CTXN1 -0.44 -8.85 -0.33 8.61e-18 Strep throat; BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg04944784 chr2:26401820 FAM59B -0.96 -16.27 -0.54 4.82e-50 Gut microbiome composition (summer); BRCA cis rs12348691 0.503 rs4743138 chr9:100614296 C/T cg13688889 chr9:100608707 NA 0.49 9.96 0.37 8.39e-22 Alopecia areata; BRCA cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.58 -11.09 -0.4 3.02e-26 Lung cancer in ever smokers; BRCA cis rs9653442 0.866 rs11123811 chr2:100760172 T/C cg22139774 chr2:100720529 AFF3 -0.31 -8.66 -0.32 3.82e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg06606381 chr12:133084897 FBRSL1 -0.88 -8.82 -0.33 1.13e-17 Depression; BRCA cis rs34172651 0.517 rs2303083 chr16:24835168 G/A cg00339695 chr16:24857497 SLC5A11 0.53 9.85 0.36 2.15e-21 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.931 rs11010130 chr10:35513307 T/C cg03585969 chr10:35415529 CREM 0.48 9.7 0.36 7.42e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs477895 0.713 rs882146 chr11:63976699 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.26 0.31 8.71e-16 Mean platelet volume; BRCA cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg15997130 chr1:24165203 NA 0.5 13.18 0.46 2.82e-35 Immature fraction of reticulocytes; BRCA cis rs12310956 0.532 rs11052920 chr12:33955891 T/G cg06521331 chr12:34319734 NA -0.52 -10.53 -0.38 4.89e-24 Morning vs. evening chronotype; BRCA cis rs4660306 0.961 rs4660862 chr1:45955056 C/T cg24296786 chr1:45957014 TESK2 0.42 8.38 0.31 3.31e-16 Homocysteine levels; BRCA cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg04455712 chr21:45112962 RRP1B 0.4 10.68 0.39 1.31e-24 Mean corpuscular volume; BRCA cis rs2014572 1.000 rs2014572 chr19:57760018 G/A cg24459738 chr19:57751996 ZNF805 -0.36 -8.54 -0.32 9.71e-17 Hyperactive-impulsive symptoms; BRCA trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.29 0.31 6.89e-16 Corneal astigmatism; BRCA cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs6815814 0.851 rs11466645 chr4:38778203 A/T cg02016764 chr4:38805732 TLR1 -0.5 -7.82 -0.3 2.17e-14 Breast cancer; BRCA cis rs4660306 1.000 rs6429569 chr1:46001330 A/C cg24296786 chr1:45957014 TESK2 0.44 9.51 0.35 3.65e-20 Homocysteine levels; BRCA cis rs832540 0.669 rs832539 chr5:56199386 A/C cg12311346 chr5:56204834 C5orf35 -0.54 -11.28 -0.41 4.68e-27 Coronary artery disease; BRCA trans rs57221529 0.766 rs58015612 chr5:580665 A/T cg11887960 chr12:57824829 NA 0.55 8.55 0.32 8.82e-17 Lung disease severity in cystic fibrosis; BRCA cis rs7607369 0.580 rs7594289 chr2:219652286 A/G cg02176678 chr2:219576539 TTLL4 -0.48 -12.79 -0.45 1.64e-33 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7172677 0.737 rs4886668 chr15:75448034 T/C cg10253484 chr15:75165896 SCAMP2 -0.42 -8.04 -0.3 4.51e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs10949834 0.793 rs810532 chr7:73505188 A/G cg07137043 chr7:73588983 EIF4H -0.49 -7.83 -0.3 2.06e-14 Verbal memory performance (residualized delayed recall change); BRCA cis rs10504229 0.953 rs75545548 chr8:58172816 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs6546886 0.912 rs7584777 chr2:74317747 T/C cg14702570 chr2:74259524 NA -0.3 -7.85 -0.3 1.78e-14 Dialysis-related mortality; BRCA cis rs61931739 0.517 rs56308002 chr12:34016021 C/G cg06521331 chr12:34319734 NA -0.62 -11.26 -0.41 5.86e-27 Morning vs. evening chronotype; BRCA cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg05234568 chr11:5960015 NA -0.38 -7.92 -0.3 1.05e-14 DNA methylation (variation); BRCA trans rs7615952 0.611 rs35321002 chr3:125612065 G/C cg07211511 chr3:129823064 LOC729375 -0.92 -14.58 -0.5 9.08e-42 Blood pressure (smoking interaction); BRCA cis rs796364 1.000 rs281785 chr2:200749566 A/G cg23649088 chr2:200775458 C2orf69 0.6 8.86 0.33 7.79e-18 Schizophrenia; BRCA cis rs36051895 0.632 rs12340617 chr9:5164492 G/C cg02405213 chr9:5042618 JAK2 -0.48 -8.86 -0.33 7.74e-18 Pediatric autoimmune diseases; BRCA cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.14 0.37 1.62e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs72781680 0.821 rs12616257 chr2:24135034 A/G cg08917208 chr2:24149416 ATAD2B 0.63 10.71 0.39 9.66e-25 Lymphocyte counts; BRCA cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg04034577 chr2:241836375 C2orf54 -0.54 -12.33 -0.44 1.79e-31 Urinary metabolites; BRCA cis rs887829 0.569 rs871514 chr2:234628529 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.52 -0.32 1.19e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1577917 0.958 rs12197463 chr6:86445242 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.24 -0.31 9.75e-16 Response to antipsychotic treatment; BRCA cis rs9527 0.615 rs11191401 chr10:104573403 A/G cg04362960 chr10:104952993 NT5C2 0.43 9.09 0.34 1.28e-18 Arsenic metabolism; BRCA cis rs1865760 0.865 rs9467648 chr6:25957933 T/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.38e-21 Height; BRCA trans rs783540 0.867 rs10906984 chr15:83366296 A/C cg18393722 chr15:85113863 UBE2QP1 0.27 8.26 0.31 8.11e-16 Schizophrenia; BRCA cis rs4285028 0.699 rs2689290 chr3:121585146 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.65 -12.61 -0.45 1e-32 Multiple sclerosis; BRCA cis rs875971 1.000 rs709597 chr7:65825983 A/G cg11764359 chr7:65958608 NA -0.81 -19.52 -0.61 6.53e-67 Aortic root size; BRCA cis rs10496034 1.000 rs79948790 chr2:55159484 C/A cg16098955 chr2:55172992 EML6 0.52 9.66 0.36 1.08e-20 Refractive astigmatism; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg04013093 chr6:42928303 GNMT -0.29 -8.9 -0.33 5.83e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg22496339 chr2:162101262 NA -0.4 -8.15 -0.31 1.86e-15 Intelligence (multi-trait analysis); BRCA cis rs1538970 0.961 rs884962 chr1:45847981 G/A cg05343316 chr1:45956843 TESK2 0.58 11.77 0.42 4.31e-29 Platelet count; BRCA cis rs7412746 0.634 rs12409208 chr1:150860055 A/G cg18016565 chr1:150552671 MCL1 0.34 7.83 0.3 2.03e-14 Melanoma; BRCA cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg05535760 chr7:792225 HEATR2 0.77 13.6 0.47 3.44e-37 Cerebrospinal P-tau181p levels; BRCA cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg22105103 chr4:187893119 NA 0.41 13.28 0.47 1.03e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs3815700 1.000 rs7247420 chr19:33096786 G/A cg02997394 chr19:33096574 ANKRD27 0.69 11.53 0.41 4.49e-28 Eosinophilic esophagitis; BRCA cis rs870825 0.721 rs72703528 chr4:185607311 A/G cg04058563 chr4:185651563 MLF1IP 0.85 14.29 0.49 2.16e-40 Blood protein levels; BRCA cis rs11051970 0.679 rs2931554 chr12:32556162 G/A cg02745156 chr12:32552066 NA 0.25 8.49 0.32 1.48e-16 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs1005277 0.540 rs1987431 chr10:37988887 T/C cg23533926 chr12:111358616 MYL2 -0.38 -8.03 -0.3 4.76e-15 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA trans rs7726839 0.561 rs4957049 chr5:579080 C/A cg25482853 chr8:67687455 SGK3 0.78 13.07 0.46 8.85e-35 Obesity-related traits; BRCA cis rs6060717 0.528 rs73905955 chr20:34332938 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Hip circumference adjusted for BMI; BRCA cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg13877915 chr19:58951672 ZNF132 0.47 11.09 0.4 2.96e-26 Uric acid clearance; BRCA cis rs4642101 0.793 rs56082700 chr3:12833833 T/C cg24848339 chr3:12840334 CAND2 0.45 12.05 0.43 2.7e-30 QRS complex (12-leadsum); BRCA cis rs7781557 1.000 rs12113073 chr7:102482527 T/C cg18108683 chr7:102477205 FBXL13 -0.44 -8.04 -0.3 4.36e-15 Colorectal adenoma (advanced); BRCA cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg05340658 chr4:99064831 C4orf37 0.63 15.32 0.52 2.3e-45 Colonoscopy-negative controls vs population controls; BRCA cis rs6930083 0.510 rs4713994 chr6:36621533 A/G cg08179530 chr6:36648295 CDKN1A -0.55 -11.81 -0.42 3.13e-29 Coronary artery disease; BRCA cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg04414720 chr1:150670196 GOLPH3L 0.35 7.91 0.3 1.17e-14 Tonsillectomy; BRCA cis rs490234 0.934 rs12553637 chr9:128277258 A/G cg14078157 chr9:128172775 NA -0.33 -7.84 -0.3 1.88e-14 Mean arterial pressure; BRCA cis rs832540 0.629 rs10055224 chr5:56081201 C/T cg24531977 chr5:56204891 C5orf35 0.47 9.63 0.36 1.41e-20 Coronary artery disease; BRCA cis rs7481584 0.624 rs377765 chr11:3046298 C/T cg08508325 chr11:3079039 CARS 0.28 8.51 0.32 1.24e-16 Calcium levels; BRCA trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -10.16 -0.37 1.44e-22 Neuroticism; BRCA cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg21573476 chr21:45109991 RRP1B 0.41 11.04 0.4 4.52e-26 Mean corpuscular volume; BRCA cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg03517284 chr6:25882590 NA 0.37 7.83 0.3 2.07e-14 Intelligence (multi-trait analysis); BRCA cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg27535305 chr1:53392650 SCP2 -0.38 -9.25 -0.34 3.41e-19 Monocyte count; BRCA cis rs56399783 0.901 rs73049305 chr7:2778755 C/T cg19731401 chr7:2775893 GNA12 0.51 8.16 0.31 1.76e-15 Childhood ear infection; BRCA cis rs10789491 1.000 rs12794 chr1:47141718 T/C cg15501359 chr1:47185051 KIAA0494 0.65 18.2 0.58 5.97e-60 Response to hepatitis C treatment; BRCA cis rs4727027 0.933 rs10277119 chr7:148849942 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 9.24 0.34 3.52e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg00031303 chr3:195681400 NA 0.45 8.54 0.32 9.64e-17 Pancreatic cancer; BRCA cis rs637571 0.510 rs3892696 chr11:65582341 G/C cg26695010 chr11:65641043 EFEMP2 0.38 8.15 0.31 1.91e-15 Eosinophil percentage of white cells; BRCA cis rs1707322 0.721 rs6697821 chr1:46216722 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.16 0.43 9.79e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6964587 1.000 rs36120033 chr7:91679298 G/A cg17063962 chr7:91808500 NA 0.54 12.72 0.45 3.47e-33 Breast cancer; BRCA cis rs57590327 0.528 rs7642112 chr3:81674927 C/T cg07356753 chr3:81810745 GBE1 -0.45 -10.16 -0.37 1.46e-22 Extraversion; BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg18876405 chr7:65276391 NA 0.48 10.7 0.39 1.12e-24 Aortic root size; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg08888203 chr3:10149979 C3orf24 0.57 12.08 0.43 2.15e-30 Alzheimer's disease; BRCA cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.83 -0.36 2.47e-21 Tonsillectomy; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg08888203 chr3:10149979 C3orf24 0.63 11.82 0.42 2.73e-29 Alzheimer's disease; BRCA cis rs11718455 0.881 rs17076257 chr3:44006787 C/T cg08738300 chr3:44038990 NA 0.46 8.8 0.33 1.29e-17 Coronary artery disease; BRCA trans rs79976124 0.879 rs12213669 chr6:66627704 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.6 0.39 2.78e-24 Type 2 diabetes; BRCA cis rs4919087 0.926 rs10882884 chr10:99025611 T/A cg25902810 chr10:99078978 FRAT1 0.44 9.27 0.34 2.88e-19 Monocyte count; BRCA cis rs4423214 0.592 rs1790349 chr11:71142350 A/G cg05163923 chr11:71159392 DHCR7 -0.48 -8.24 -0.31 9.87e-16 Vitamin D levels; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.52 -0.41 4.79e-28 Lymphocyte counts; BRCA cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg26031613 chr14:104095156 KLC1 -0.42 -8.39 -0.32 3.01e-16 Schizophrenia; BRCA cis rs6545883 0.929 rs1186710 chr2:61688727 T/A cg15711740 chr2:61764176 XPO1 -0.54 -13.66 -0.48 1.81e-37 Tuberculosis; BRCA cis rs10754283 0.934 rs1934043 chr1:90106645 C/T cg21401794 chr1:90099060 LRRC8C 0.46 11.13 0.4 2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs243505 0.661 rs887570 chr7:148505255 A/G cg09806900 chr7:148480153 CUL1 0.5 10.6 0.39 2.7e-24 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg04546413 chr19:29218101 NA -0.56 -9.72 -0.36 6.32e-21 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs4906332 0.811 rs2021965 chr14:103997248 C/A cg04998671 chr14:104000505 TRMT61A 0.49 10.13 0.37 1.75e-22 Coronary artery disease; BRCA cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg19077165 chr18:44547161 KATNAL2 -0.51 -10.51 -0.38 6.01e-24 Personality dimensions; BRCA cis rs1371614 0.632 rs3769135 chr2:27168411 G/A cg00617064 chr2:27272375 NA 0.32 8.29 0.31 6.53e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs61931739 0.500 rs11053140 chr12:34316122 T/C cg06521331 chr12:34319734 NA -0.65 -11.92 -0.43 1.03e-29 Morning vs. evening chronotype; BRCA cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg16230307 chr14:35515116 FAM177A1 0.73 15.12 0.51 2.22e-44 Psoriasis; BRCA cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg08109568 chr15:31115862 NA -0.43 -9.58 -0.35 2.13e-20 Huntington's disease progression; BRCA cis rs3806843 1.000 rs2337985 chr5:140157861 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.77 -0.36 4.06e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs4363385 0.747 rs6704105 chr1:152964397 C/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.63 -0.32 4.79e-17 Inflammatory skin disease; BRCA cis rs6546886 0.957 rs4853005 chr2:74258049 G/C cg14702570 chr2:74259524 NA -0.32 -8.17 -0.31 1.63e-15 Dialysis-related mortality; BRCA cis rs4664304 0.658 rs2667016 chr2:160868855 C/T cg14819504 chr2:160761413 LY75 -0.33 -8.14 -0.31 2.13e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 18.46 0.59 2.64e-61 Alzheimer's disease; BRCA cis rs2425143 1.000 rs6060572 chr20:34294015 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.92 -0.37 1.12e-21 Blood protein levels; BRCA trans rs6461049 0.800 rs3800909 chr7:2159594 C/G cg04565464 chr8:145669602 NFKBIL2 0.41 9.85 0.36 2.08e-21 Schizophrenia; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg03923535 chr7:1197113 ZFAND2A 0.5 10.88 0.4 2.05e-25 Longevity;Endometriosis; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg08132940 chr7:1081526 C7orf50 -0.58 -8.81 -0.33 1.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7394190 0.748 rs11000780 chr10:75559077 G/A cg07699608 chr10:75541558 CHCHD1 0.7 10.37 0.38 2.25e-23 Incident atrial fibrillation; BRCA cis rs4481887 0.927 rs10157089 chr1:248488157 A/G cg00666640 chr1:248458726 OR2T12 0.3 8.58 0.32 7.32e-17 Common traits (Other); BRCA cis rs611744 0.647 rs579162 chr8:109254842 A/G cg21045802 chr8:109455806 TTC35 0.35 7.96 0.3 8.09e-15 Dupuytren's disease; BRCA cis rs853679 0.517 rs9368553 chr6:28082265 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.64 16.38 0.54 1.32e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs73001065 0.901 rs73004962 chr19:19713069 A/T cg03709012 chr19:19516395 GATAD2A 0.79 9.81 0.36 2.96e-21 LDL cholesterol; BRCA cis rs8031584 0.918 rs61997140 chr15:31277312 A/G cg08704250 chr15:31115839 NA -0.36 -9.02 -0.34 2.23e-18 Huntington's disease progression; BRCA cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg20203395 chr5:56204925 C5orf35 0.43 9.6 0.35 1.85e-20 Initial pursuit acceleration; BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg07757535 chr4:1339547 NA 0.25 8.07 0.3 3.45e-15 Longevity; BRCA cis rs700651 0.753 rs10207232 chr2:198893813 A/G cg00792783 chr2:198669748 PLCL1 0.42 9.31 0.35 1.98e-19 Intracranial aneurysm; BRCA cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg18270830 chr10:32634957 EPC1 0.58 10.11 0.37 2.1e-22 Sexual dysfunction (female); BRCA cis rs7762018 1.000 rs6912959 chr6:170126224 G/A cg19338460 chr6:170058176 WDR27 -0.45 -7.85 -0.3 1.72e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs68092024 0.731 rs793479 chr3:99488232 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.56 -0.39 3.85e-24 Cleft lip with or without cleft palate; BRCA cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg22535103 chr8:58192502 C8orf71 -0.6 -12.92 -0.46 4.2e-34 Developmental language disorder (linguistic errors); BRCA cis rs751728 0.687 rs943471 chr6:33738314 C/T cg25922239 chr6:33757077 LEMD2 0.52 13.18 0.46 2.84e-35 Crohn's disease; BRCA cis rs858239 0.601 rs15775 chr7:23164701 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.93 0.43 8.98e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg07134254 chr20:33865797 NA -0.42 -7.99 -0.3 6.54e-15 Attention deficit hyperactivity disorder; BRCA cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.52 8.44 0.32 2.2e-16 Renal function-related traits (BUN); BRCA cis rs2239547 0.603 rs2276825 chr3:52886605 T/C cg18404041 chr3:52824283 ITIH1 -0.35 -9.09 -0.34 1.23e-18 Schizophrenia; BRCA cis rs9462027 0.628 rs2814942 chr6:34644261 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.91 -0.3 1.1e-14 Systemic lupus erythematosus; BRCA trans rs2204008 0.869 rs34438288 chr12:38211582 G/T cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs16866061 1.000 rs72974222 chr2:225424143 C/T cg12698349 chr2:225449008 CUL3 0.78 21.13 0.64 1.39e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2742234 0.915 rs2742233 chr10:43610558 C/T cg02780029 chr10:43622663 RET -0.41 -10.21 -0.37 9.01e-23 Hirschsprung disease; BRCA cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.0 0.3 5.89e-15 Diabetic retinopathy; BRCA cis rs9311474 0.607 rs4687625 chr3:52563718 C/T cg10802521 chr3:52805072 NEK4 -0.3 -7.91 -0.3 1.12e-14 Electroencephalogram traits; BRCA cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs17253792 0.822 rs10083431 chr14:56068348 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA cis rs7786808 0.707 rs10247026 chr7:158230595 C/T cg01191920 chr7:158217561 PTPRN2 -0.47 -10.96 -0.4 9.69e-26 Obesity-related traits; BRCA cis rs3820928 0.692 rs17416354 chr2:227770844 A/G cg11843606 chr2:227700838 RHBDD1 -0.52 -12.03 -0.43 3.55e-30 Pulmonary function; BRCA cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg23711669 chr6:146136114 FBXO30 -0.77 -18.05 -0.58 3.66e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg13752114 chr3:195489708 MUC4 -0.57 -9.16 -0.34 6.84e-19 Lung disease severity in cystic fibrosis; BRCA cis rs17604090 0.941 rs114036198 chr7:29676300 C/T cg19413766 chr7:29689036 LOC646762 -0.64 -8.76 -0.33 1.77e-17 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs9790314 1.000 rs336548 chr3:161058412 T/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.04 -0.49 3.32e-39 Morning vs. evening chronotype; BRCA cis rs1401999 1.000 rs10937158 chr3:183708439 T/C cg01324343 chr3:183735012 ABCC5 0.83 21.19 0.64 6.89e-76 Anterior chamber depth; BRCA cis rs9486719 1.000 rs2064947 chr6:97052754 C/T cg06623918 chr6:96969491 KIAA0776 -0.7 -12.58 -0.45 1.34e-32 Migraine;Coronary artery disease; BRCA cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6700896 0.931 rs10789193 chr1:66129646 A/T cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs208520 0.526 rs9354366 chr6:66788559 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.15 -39.43 -0.84 2.74e-173 Exhaled nitric oxide output; BRCA cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.82e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 16.9 0.56 3.23e-53 Electrocardiographic conduction measures; BRCA cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg11764359 chr7:65958608 NA 0.67 12.68 0.45 5.19e-33 Aortic root size; BRCA cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg15506890 chr2:3487001 NA -0.57 -12.67 -0.45 5.82e-33 Neurofibrillary tangles; BRCA cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg05623727 chr3:50126028 RBM5 0.41 9.75 0.36 4.97e-21 Intelligence (multi-trait analysis); BRCA cis rs17023223 0.537 rs12064137 chr1:119709749 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.25e-16 Monocyte percentage of white cells; BRCA cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg08392591 chr16:89556376 ANKRD11 0.46 10.93 0.4 1.32e-25 Multiple myeloma (IgH translocation); BRCA cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg25945732 chr2:264204 ACP1;SH3YL1 0.49 9.35 0.35 1.4e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg08992911 chr2:238395768 MLPH 0.4 8.65 0.32 4.3e-17 Prostate cancer; BRCA cis rs7927592 0.956 rs10896341 chr11:68313180 G/A cg20283391 chr11:68216788 NA -0.46 -9.01 -0.34 2.42e-18 Total body bone mineral density; BRCA cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg02951883 chr7:2050386 MAD1L1 -0.41 -9.43 -0.35 7.72e-20 Bipolar disorder and schizophrenia; BRCA trans rs7618501 0.966 rs13063621 chr3:49821625 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.54 16.92 0.56 2.51e-53 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg21918786 chr6:109611834 NA -0.44 -12.21 -0.44 5.58e-31 Reticulocyte fraction of red cells; BRCA cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg10792982 chr14:105748885 BRF1 0.48 11.26 0.41 5.66e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs10465746 1.000 rs10465746 chr1:84387632 T/G cg10977910 chr1:84465055 TTLL7 0.5 10.16 0.37 1.38e-22 Obesity-related traits; BRCA cis rs12586317 0.547 rs10146699 chr14:35483577 G/A cg16230307 chr14:35515116 FAM177A1 0.73 15.12 0.51 2.22e-44 Psoriasis; BRCA cis rs910316 0.687 rs175059 chr14:75490667 T/C cg23033748 chr14:75592666 NEK9 -0.35 -8.22 -0.31 1.14e-15 Height; BRCA cis rs9807989 0.524 rs7591246 chr2:102999403 C/A cg03938978 chr2:103052716 IL18RAP 0.29 8.41 0.32 2.59e-16 Asthma; BRCA trans rs61931739 0.500 rs7310576 chr12:34474735 T/C cg26384229 chr12:38710491 ALG10B 0.57 12.76 0.45 2.24e-33 Morning vs. evening chronotype; BRCA cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 10.85 0.39 2.75e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6867032 0.917 rs10474734 chr5:2004208 A/G cg26168224 chr5:2018326 NA 0.53 12.94 0.46 3.34e-34 Gut microbiome composition (winter); BRCA cis rs67981189 0.896 rs2526877 chr14:71433322 T/C cg15816911 chr14:71606274 NA -0.35 -7.84 -0.3 1.95e-14 Schizophrenia; BRCA cis rs4363385 0.669 rs2937264 chr1:153011026 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg27170947 chr2:26402098 FAM59B -0.92 -16.84 -0.55 6.2e-53 Gut microbiome composition (summer); BRCA trans rs3858145 0.588 rs731063 chr10:70043190 A/G cg04882175 chr6:131122610 NA 0.34 8.23 0.31 1.08e-15 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg24812749 chr6:127587940 RNF146 0.89 20.97 0.64 1.08e-74 Breast cancer; BRCA cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.46 -8.76 -0.33 1.71e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg18404041 chr3:52824283 ITIH1 -0.32 -9.55 -0.35 2.65e-20 Bipolar disorder; BRCA cis rs9467773 0.836 rs1624440 chr6:26433329 G/A cg09904177 chr6:26538194 HMGN4 -0.47 -13.34 -0.47 5.25e-36 Intelligence (multi-trait analysis); BRCA cis rs13064411 0.542 rs2087130 chr3:113226983 T/A cg18753928 chr3:113234510 CCDC52 -0.45 -9.59 -0.35 2.01e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs6714710 0.580 rs17489915 chr2:98420431 T/C cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.86e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA trans rs11098499 0.738 rs28408407 chr4:120376030 C/G cg25214090 chr10:38739885 LOC399744 0.54 12.64 0.45 7.24e-33 Corneal astigmatism; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg16590910 chr6:42928470 GNMT 0.42 9.24 0.34 3.62e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.3 9.93 0.37 1.02e-21 Cognitive function; BRCA trans rs6479891 1.000 rs12411988 chr10:65315397 C/G cg14819942 chr15:35414228 NA -0.34 -7.98 -0.3 6.83e-15 Arthritis (juvenile idiopathic); BRCA cis rs4268898 0.662 rs58971404 chr2:24403753 G/A cg06627628 chr2:24431161 ITSN2 -0.82 -14.83 -0.51 5.87e-43 Asthma; BRCA cis rs2836974 0.966 rs2836977 chr21:40666066 T/C cg11890956 chr21:40555474 PSMG1 1.04 28.93 0.75 2.84e-118 Cognitive function; BRCA cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg11301795 chr4:187892539 NA -0.31 -9.99 -0.37 6.25e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg04317338 chr11:64019027 PLCB3 -0.54 -9.79 -0.36 3.57e-21 Mean platelet volume; BRCA cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.0 -12.5 -0.44 3.26e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.6 -0.61 2.57e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs72772090 0.539 rs17481856 chr5:96116808 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11874712 1.000 rs1800637 chr18:43670190 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs2153535 0.623 rs2152346 chr6:8454652 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg16506815 chr2:162101123 NA 0.72 17.97 0.58 9.94e-59 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.9 -0.36 1.3e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs6763687 0.651 rs4894800 chr3:171798127 A/C cg16233210 chr3:171778391 FNDC3B 0.35 7.82 0.3 2.16e-14 Red cell distribution width; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg04234412 chr22:24373322 LOC391322 -0.62 -15.66 -0.53 5.05e-47 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg03146154 chr1:46216737 IPP 0.45 10.08 0.37 2.88e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6942756 0.876 rs6953598 chr7:129033741 A/G cg02491457 chr7:128862824 NA 0.61 12.47 0.44 4.12e-32 White matter hyperintensity burden; BRCA cis rs2522056 0.808 rs1016988 chr5:131744574 T/C cg24060327 chr5:131705240 SLC22A5 0.55 8.97 0.33 3.16e-18 Lymphocyte counts;Fibrinogen; BRCA cis rs9393777 0.513 rs6913660 chr6:27091425 C/A cg12292205 chr6:26970375 C6orf41 -0.64 -9.97 -0.37 7.21e-22 Intelligence (multi-trait analysis); BRCA cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg27478167 chr7:817139 HEATR2 -0.43 -9.09 -0.34 1.23e-18 Cerebrospinal P-tau181p levels; BRCA cis rs1577917 0.771 rs9362239 chr6:86429263 G/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.33 9.02 0.34 2.09e-18 Response to antipsychotic treatment; BRCA cis rs7631605 0.608 rs116724099 chr3:37431641 C/T cg15934958 chr3:37212084 LRRFIP2 0.37 8.11 0.31 2.61e-15 Cerebrospinal P-tau181p levels; BRCA cis rs7772486 0.846 rs2892453 chr6:146377717 C/A cg23711669 chr6:146136114 FBXO30 0.65 15.07 0.51 3.93e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg17845761 chr1:175162550 KIAA0040 -0.26 -9.84 -0.36 2.24e-21 Alcohol dependence; BRCA cis rs894734 1.000 rs894734 chr12:54319727 A/G cg17410650 chr12:54324560 NA -0.31 -8.04 -0.3 4.46e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); BRCA cis rs78487399 0.908 rs61754256 chr2:43805739 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.95 -0.3 8.45e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs2180341 0.595 rs7771391 chr6:127749656 C/G cg27446573 chr6:127587934 RNF146 0.61 13.19 0.46 2.51e-35 Breast cancer; BRCA cis rs9467773 0.967 rs9358954 chr6:26531178 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs67311347 1.000 rs1119179 chr3:40424929 A/C cg01475735 chr3:40494733 NA 0.42 8.5 0.32 1.36e-16 Renal cell carcinoma; BRCA cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 12.11 0.43 1.63e-30 Personality dimensions; BRCA cis rs9486715 1.000 rs2273621 chr6:97058553 A/G cg06623918 chr6:96969491 KIAA0776 -0.86 -23.63 -0.68 3.27e-89 Headache; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.73 -0.33 2.17e-17 Total body bone mineral density; BRCA cis rs7267979 0.934 rs2261115 chr20:25259807 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.33 0.35 1.76e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -9.5 -0.35 4.19e-20 Personality dimensions; BRCA cis rs1971762 0.583 rs7979659 chr12:54086579 A/G cg23533419 chr12:54090519 NA -0.31 -7.81 -0.3 2.32e-14 Height; BRCA cis rs877529 0.932 rs139398 chr22:39544970 C/G cg18708252 chr22:39545030 CBX7 -0.32 -8.05 -0.3 4.13e-15 Multiple myeloma; BRCA cis rs11971779 0.616 rs6949963 chr7:139054325 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs490234 0.729 rs10819050 chr9:128237178 G/T cg14078157 chr9:128172775 NA -0.37 -8.79 -0.33 1.38e-17 Mean arterial pressure; BRCA cis rs8062405 0.722 rs3785354 chr16:28550667 C/T cg16576597 chr16:28551801 NUPR1 0.35 9.66 0.36 1.11e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs68170813 0.599 rs12532514 chr7:107000952 C/T cg02696742 chr7:106810147 HBP1 -0.55 -8.6 -0.32 6.09e-17 Coronary artery disease; BRCA cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg25838465 chr1:92012736 NA -0.45 -9.91 -0.36 1.24e-21 Eosinophil percentage of white cells; BRCA cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs614226 1.000 rs616157 chr12:120925795 T/C cg27489772 chr12:121021490 NA -0.49 -8.35 -0.31 4.24e-16 Type 1 diabetes nephropathy; BRCA cis rs1395 0.744 rs9653564 chr2:27472618 G/A cg23587288 chr2:27483067 SLC30A3 -0.38 -8.85 -0.33 8.76e-18 Blood metabolite levels; BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.2 -0.43 6.44e-31 Alzheimer's disease; BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg14196790 chr5:131705035 SLC22A5 0.32 8.64 0.32 4.5e-17 Breast cancer; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.05 21.87 0.65 1.42e-79 Gut microbiome composition (summer); BRCA cis rs3008870 1.000 rs3008894 chr1:67377739 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 19.49 0.61 9.83e-67 Lymphocyte percentage of white cells; BRCA cis rs2386661 0.547 rs57893347 chr10:5646191 G/A cg17085576 chr10:5658249 NA -0.33 -8.23 -0.31 1.04e-15 Breast cancer; BRCA cis rs10911232 0.507 rs28477876 chr1:183019882 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.82 0.55 7.52e-53 Hypertriglyceridemia; BRCA cis rs13033859 0.526 rs6548221 chr2:295255 C/T cg12623918 chr2:306882 NA -0.36 -8.3 -0.31 6.1e-16 Mitochondrial DNA levels; BRCA cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg26116260 chr4:7069785 GRPEL1 0.41 10.13 0.37 1.77e-22 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; BRCA cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg12927641 chr6:109611667 NA -0.43 -11.08 -0.4 3.29e-26 Reticulocyte fraction of red cells; BRCA cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11890956 chr21:40555474 PSMG1 -0.6 -13.51 -0.47 8.99e-37 Menarche (age at onset); BRCA cis rs2629540 0.543 rs2559515 chr10:126513925 A/G cg08799069 chr10:126477246 METTL10 0.48 8.63 0.32 4.87e-17 Cocaine dependence; BRCA cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg04450456 chr4:17643702 FAM184B -0.34 -9.62 -0.36 1.51e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1580019 0.713 rs2167274 chr7:32524844 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.03 26.87 0.73 5.14e-107 Cognitive ability; BRCA cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg09469691 chr10:81107165 PPIF 0.45 9.76 0.36 4.69e-21 Height; BRCA trans rs9325144 0.647 rs11169189 chr12:39097078 A/T cg23762105 chr12:34175262 ALG10 0.34 7.81 0.3 2.39e-14 Morning vs. evening chronotype; BRCA cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg15556689 chr8:8085844 FLJ10661 0.48 13.54 0.47 6.61e-37 Parkinson's disease; BRCA cis rs6598955 0.671 rs11247905 chr1:26627907 G/C cg00852783 chr1:26633632 UBXN11 -0.47 -8.51 -0.32 1.22e-16 Obesity-related traits; BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg24829409 chr8:58192753 C8orf71 -0.44 -8.45 -0.32 2e-16 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.61 -11.36 -0.41 2.34e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9283706 0.562 rs6881240 chr5:66331471 G/A cg11590213 chr5:66331682 MAST4 0.4 7.99 0.3 6.5e-15 Coronary artery disease; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg22907277 chr7:1156413 C7orf50 0.45 10.48 0.38 7.93e-24 Longevity;Endometriosis; BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.89 0.6 1.52e-63 Tonsillectomy; BRCA cis rs7103648 0.669 rs11039332 chr11:47695840 G/A cg20307385 chr11:47447363 PSMC3 0.74 17.0 0.56 9.98e-54 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2625529 0.824 rs16953769 chr15:72463325 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.78 -0.58 8.71e-58 Red blood cell count; BRCA cis rs9325144 0.534 rs1843866 chr12:38703160 G/T cg26384229 chr12:38710491 ALG10B 0.51 13.55 0.47 5.92e-37 Morning vs. evening chronotype; BRCA trans rs61931739 0.534 rs10844801 chr12:34230940 A/T cg13010199 chr12:38710504 ALG10B 0.46 9.02 0.34 2.14e-18 Morning vs. evening chronotype; BRCA cis rs79839061 0.656 rs11726912 chr4:887868 A/C cg14530993 chr4:882597 GAK 0.57 10.17 0.37 1.28e-22 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.36 -8.11 -0.31 2.53e-15 Alzheimer's disease (late onset); BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg04063615 chr12:132293388 NA -0.47 -10.23 -0.38 7.56e-23 Migraine; BRCA cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.93 -0.43 9.64e-30 Personality dimensions; BRCA cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg14349672 chr11:133703707 NA -0.35 -8.49 -0.32 1.47e-16 Childhood ear infection; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg24642844 chr7:1081250 C7orf50 -0.68 -12.77 -0.45 2.03e-33 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7582180 0.629 rs12612809 chr2:100951616 G/T cg14675211 chr2:100938903 LONRF2 0.51 11.7 0.42 9.02e-29 Intelligence (multi-trait analysis); BRCA trans rs11165623 0.564 rs7541109 chr1:96995960 C/A cg10631902 chr5:14652156 NA -0.43 -12.17 -0.43 8.99e-31 Hip circumference;Waist circumference; BRCA cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg23029597 chr12:123009494 RSRC2 -0.6 -11.6 -0.42 2.38e-28 Body mass index; BRCA cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg04025307 chr7:1156635 C7orf50 0.46 8.86 0.33 8.12e-18 Bronchopulmonary dysplasia; BRCA cis rs7762018 0.556 rs80250989 chr6:170105553 T/C cg19338460 chr6:170058176 WDR27 -0.75 -10.0 -0.37 5.47e-22 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.18 -0.34 6.08e-19 Total body bone mineral density; BRCA cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs7523273 0.606 rs2796262 chr1:207915180 G/A cg22525895 chr1:207977042 MIR29B2 0.47 12.04 0.43 2.97e-30 Schizophrenia; BRCA cis rs763121 0.962 rs2071887 chr22:38879010 A/T cg06022373 chr22:39101656 GTPBP1 0.51 12.19 0.43 7.34e-31 Menopause (age at onset); BRCA cis rs35306767 0.714 rs28512382 chr10:1092195 G/C cg18964960 chr10:1102726 WDR37 0.66 9.22 0.34 4.25e-19 Eosinophil percentage of granulocytes; BRCA cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg27446573 chr6:127587934 RNF146 0.7 15.78 0.53 1.3e-47 Breast cancer; BRCA trans rs11039798 0.512 rs1588069 chr11:48694871 A/G cg15704280 chr7:45808275 SEPT13 0.62 10.32 0.38 3.42e-23 Axial length; BRCA cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg11266682 chr4:10021025 SLC2A9 0.48 12.76 0.45 2.23e-33 Bone mineral density; BRCA cis rs13102973 0.899 rs13104539 chr4:135904385 G/A cg14419869 chr4:135874104 NA 0.46 9.16 0.34 7.08e-19 Subjective well-being; BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg14004847 chr7:1930337 MAD1L1 0.42 8.49 0.32 1.41e-16 Bipolar disorder and schizophrenia; BRCA cis rs1707322 1.000 rs1707303 chr1:46598273 A/C cg06784218 chr1:46089804 CCDC17 -0.43 -9.67 -0.36 1.02e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.16 0.4 1.58e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg08999081 chr20:33150536 PIGU -0.46 -12.8 -0.45 1.5e-33 Glomerular filtration rate (creatinine); BRCA cis rs897080 0.515 rs1067333 chr2:44626710 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.55 10.5 0.38 6.83e-24 Height; BRCA cis rs2249625 0.874 rs1819067 chr6:72849139 A/C cg18830697 chr6:72922368 RIMS1 -0.37 -7.89 -0.3 1.31e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs2559856 0.935 rs2559864 chr12:102084710 C/G cg12924262 chr12:102091054 CHPT1 0.36 8.15 0.31 1.88e-15 Blood protein levels; BRCA cis rs4728302 0.583 rs12707091 chr7:133185749 A/G cg10665199 chr7:133106180 EXOC4 0.45 9.33 0.35 1.7e-19 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs17270561 0.636 rs9348696 chr6:25781938 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 9.22 0.34 4.19e-19 Iron status biomarkers; BRCA cis rs4803468 0.967 rs11083619 chr19:41913267 A/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.66 -0.68 2.33e-89 Height; BRCA trans rs11098499 0.909 rs11723839 chr4:120299673 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.85 -0.3 1.79e-14 Corneal astigmatism; BRCA cis rs9487051 0.872 rs9372211 chr6:109609648 C/T cg12927641 chr6:109611667 NA -0.42 -10.89 -0.4 1.94e-25 Reticulocyte fraction of red cells; BRCA cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg13880726 chr7:1868755 MAD1L1 0.52 10.54 0.38 4.87e-24 Bipolar disorder and schizophrenia; BRCA cis rs2625529 0.617 rs7175373 chr15:72203517 G/T cg16672083 chr15:72433130 SENP8 0.64 15.4 0.52 9.29e-46 Red blood cell count; BRCA cis rs7246657 0.551 rs28462002 chr19:37634462 A/G cg23950597 chr19:37808831 NA -0.6 -9.18 -0.34 5.78e-19 Coronary artery calcification; BRCA cis rs3845702 0.736 rs12693214 chr2:180825685 G/A cg01881094 chr2:180872142 CWC22 -1.02 -17.23 -0.56 6.17e-55 Schizophrenia; BRCA cis rs12545109 0.800 rs1996106 chr8:57412963 A/G cg09654669 chr8:57350985 NA -0.38 -8.34 -0.31 4.55e-16 Obesity-related traits; BRCA cis rs7651039 1.000 rs7651039 chr3:15648004 C/T cg16303742 chr3:15540471 COLQ -0.4 -9.33 -0.35 1.69e-19 Coronary heart disease; BRCA cis rs11792861 0.962 rs72607161 chr9:111792640 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.86 0.3 1.66e-14 Menarche (age at onset); BRCA cis rs9914988 0.943 rs66588554 chr17:27141110 A/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.82 -0.33 1.08e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs9467773 1.000 rs1321481 chr6:26538210 A/T cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg08045932 chr20:61659980 NA 0.5 11.54 0.42 4.01e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs365132 0.846 rs812246 chr5:176327644 G/A cg16309518 chr5:176445507 NA -0.39 -9.59 -0.35 1.87e-20 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg23796481 chr11:64053134 BAD;GPR137 0.5 10.26 0.38 5.7e-23 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs4363385 0.747 rs12048412 chr1:152977092 A/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.49 -0.35 4.45e-20 Inflammatory skin disease; BRCA cis rs7092929 0.883 rs588410 chr10:3618792 T/C cg14308648 chr10:3568949 NA 0.46 8.57 0.32 7.73e-17 Coronary artery calcification; BRCA cis rs7677751 0.806 rs4864859 chr4:55090015 A/G cg17187183 chr4:55093834 PDGFRA 0.44 9.35 0.35 1.48e-19 Corneal astigmatism; BRCA cis rs3818285 0.556 rs3758409 chr10:111669239 A/C cg00817464 chr10:111662876 XPNPEP1 -0.42 -10.6 -0.39 2.65e-24 Superior crus of antihelix expression; BRCA cis rs9790314 1.000 rs459697 chr3:161093420 G/A cg03342759 chr3:160939853 NMD3 -0.63 -13.48 -0.47 1.21e-36 Morning vs. evening chronotype; BRCA cis rs2066819 1.000 rs80317430 chr12:56727705 G/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs832540 0.519 rs10940518 chr5:56270794 C/T cg24531977 chr5:56204891 C5orf35 -0.43 -8.52 -0.32 1.1e-16 Coronary artery disease; BRCA cis rs74181299 0.819 rs2723086 chr2:65297686 C/T cg05010058 chr2:65284262 CEP68 0.3 8.38 0.31 3.37e-16 Pulse pressure; BRCA cis rs73001065 0.591 rs11668386 chr19:19531910 A/G cg03709012 chr19:19516395 GATAD2A 1.04 14.3 0.49 1.98e-40 LDL cholesterol; BRCA cis rs801193 0.548 rs6975044 chr7:66227482 C/T cg18876405 chr7:65276391 NA 0.47 10.53 0.38 5.26e-24 Aortic root size; BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg11062466 chr8:58055876 NA 0.57 9.63 0.36 1.44e-20 Developmental language disorder (linguistic errors); BRCA cis rs4268898 0.552 rs4665663 chr2:24372139 G/C cg26838691 chr2:24397539 C2orf84 0.4 8.14 0.31 2.11e-15 Asthma; BRCA trans rs3960554 0.529 rs1859795 chr7:75877354 A/G cg19862616 chr7:65841803 NCRNA00174 0.43 9.97 0.37 7.55e-22 Eotaxin levels; BRCA cis rs1008375 0.932 rs9291660 chr4:17663414 A/G cg16339924 chr4:17578868 LAP3 0.66 15.53 0.52 2.29e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg05872129 chr22:39784769 NA -0.57 -13.0 -0.46 1.81e-34 Intelligence (multi-trait analysis); BRCA trans rs7980799 0.653 rs11052722 chr12:33626530 G/A cg26384229 chr12:38710491 ALG10B -0.41 -8.93 -0.33 4.51e-18 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.65 0.77 1.32e-127 Chronic sinus infection; BRCA trans rs4332037 0.624 rs11764124 chr7:1891723 C/G cg11693508 chr17:37793320 STARD3 0.61 11.44 0.41 1.04e-27 Bipolar disorder; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg19346786 chr7:2764209 NA 0.32 9.6 0.35 1.83e-20 Height; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg21782813 chr7:2030301 MAD1L1 0.42 11.34 0.41 2.83e-27 Bipolar disorder and schizophrenia; BRCA cis rs9283706 0.608 rs71626484 chr5:66334502 A/T cg11590213 chr5:66331682 MAST4 0.38 7.98 0.3 6.69e-15 Coronary artery disease; BRCA cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg00074818 chr8:8560427 CLDN23 0.38 8.37 0.31 3.69e-16 Obesity-related traits; BRCA cis rs2370759 1.000 rs7910776 chr10:32639093 C/T cg18270830 chr10:32634957 EPC1 0.59 9.71 0.36 6.86e-21 Sexual dysfunction (female); BRCA cis rs4595586 0.545 rs58154430 chr12:39386649 C/T cg26384229 chr12:38710491 ALG10B 0.55 11.69 0.42 9.73e-29 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.77e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18758796 chr5:131593413 PDLIM4 0.39 9.94 0.37 9.96e-22 Acylcarnitine levels; BRCA cis rs7584330 0.737 rs10445707 chr2:238368751 A/G cg11271282 chr2:238384023 NA 0.44 8.4 0.32 2.91e-16 Prostate cancer; BRCA cis rs9649465 0.967 rs13239184 chr7:123314618 G/T cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -11.44 -0.41 1.04e-27 Personality dimensions; BRCA cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg15017067 chr4:17643749 FAM184B 0.31 8.63 0.32 4.73e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4900538 0.963 rs8017980 chr14:102961341 C/G cg18135206 chr14:102964638 TECPR2 1.05 29.55 0.76 1.18e-121 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12826209 chr6:26865740 GUSBL1 0.59 10.31 0.38 3.81e-23 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.516 rs9295684 chr6:26069669 T/C cg17691542 chr6:26056736 HIST1H1C 0.53 11.44 0.41 1.1e-27 Height; BRCA cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg14458575 chr2:238380390 NA -0.54 -12.09 -0.43 1.91e-30 Prostate cancer; BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg22907277 chr7:1156413 C7orf50 0.6 11.71 0.42 8e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10746514 0.786 rs9308486 chr1:232246418 A/G cg09506761 chr1:232265262 NA 0.48 10.38 0.38 1.95e-23 Response to statin therapy; BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg12564285 chr5:131593104 PDLIM4 0.42 10.12 0.37 1.96e-22 Acylcarnitine levels; BRCA cis rs7927771 1.000 rs10838747 chr11:47716324 G/C cg18512352 chr11:47633146 NA -0.35 -8.4 -0.32 2.88e-16 Subjective well-being; BRCA cis rs6772849 0.930 rs12487604 chr3:128337075 T/A cg16766828 chr3:128327626 NA -0.41 -8.44 -0.32 2.14e-16 Monocyte percentage of white cells;Monocyte count; BRCA cis rs910316 1.000 rs175442 chr14:75603564 T/C cg08847533 chr14:75593920 NEK9 -0.87 -22.33 -0.66 4.66e-82 Height; BRCA cis rs10851411 0.697 rs41315252 chr15:42837497 A/G cg21293051 chr15:42870591 STARD9 0.51 8.68 0.32 3.27e-17 Glucose homeostasis traits; BRCA cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg18446336 chr7:2847575 GNA12 -0.35 -8.26 -0.31 8.47e-16 Height; BRCA cis rs11250464 0.736 rs5015512 chr10:1411923 T/C cg08668359 chr10:1443807 ADARB2 0.49 9.46 0.35 5.91e-20 Radiation response; BRCA cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06873352 chr17:61820015 STRADA -0.36 -7.96 -0.3 7.62e-15 Height; BRCA cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs7580658 0.521 rs2404535 chr2:127947709 A/G cg16751203 chr2:127950803 CYP27C1 -0.28 -7.95 -0.3 8.2e-15 Protein C levels; BRCA cis rs10242455 0.557 rs45529541 chr7:99048143 C/A cg18809830 chr7:99032528 PTCD1 -0.58 -8.7 -0.33 2.87e-17 Blood metabolite levels; BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg00106254 chr7:1943704 MAD1L1 -0.42 -11.49 -0.41 6.57e-28 Bipolar disorder and schizophrenia; BRCA cis rs600550 0.528 rs7102260 chr11:59846035 A/T cg02771260 chr11:59836817 MS4A3 -0.52 -11.28 -0.41 4.8e-27 Lipoprotein-associated phospholipase A2 activity and mass; BRCA trans rs61931739 0.500 rs11053140 chr12:34316122 T/C cg26384229 chr12:38710491 ALG10B 0.67 14.21 0.49 5.23e-40 Morning vs. evening chronotype; BRCA cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11890956 chr21:40555474 PSMG1 1.04 29.87 0.76 2.31e-123 Cognitive function; BRCA cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg16586182 chr3:47516702 SCAP -0.55 -12.35 -0.44 1.4e-31 Colorectal cancer; BRCA cis rs6598955 0.671 rs11247901 chr1:26612693 T/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.5 -0.32 1.31e-16 Obesity-related traits; BRCA cis rs6061231 0.793 rs6061512 chr20:60976929 G/A cg24112000 chr20:60950667 NA -0.54 -10.57 -0.39 3.55e-24 Colorectal cancer; BRCA cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg06028605 chr16:24865363 SLC5A11 -0.41 -9.37 -0.35 1.22e-19 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.855 rs6090203 chr20:61663632 G/A cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg21918786 chr6:109611834 NA -0.49 -14.04 -0.49 3.1e-39 Reticulocyte fraction of red cells; BRCA trans rs7647973 0.626 rs35129566 chr3:49866584 T/G cg21659725 chr3:3221576 CRBN 0.47 8.74 0.33 2.11e-17 Menarche (age at onset); BRCA cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg09658497 chr7:2847517 GNA12 -0.42 -8.69 -0.33 3.02e-17 Height; BRCA cis rs10267417 0.657 rs28833898 chr7:19861022 G/A cg05791153 chr7:19748676 TWISTNB 0.52 9.83 0.36 2.55e-21 Night sleep phenotypes; BRCA cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg15212455 chr7:39170539 POU6F2 0.45 9.89 0.36 1.53e-21 IgG glycosylation; BRCA cis rs7523273 0.548 rs3109808 chr1:207948477 C/A cg22525895 chr1:207977042 MIR29B2 0.46 11.54 0.42 4.08e-28 Schizophrenia; BRCA cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.83 -0.3 1.98e-14 Bipolar disorder; BRCA cis rs6977660 0.714 rs7798760 chr7:19803487 T/C cg07541023 chr7:19748670 TWISTNB 0.55 9.54 0.35 2.93e-20 Thyroid stimulating hormone; BRCA cis rs6570726 0.935 rs409725 chr6:145840340 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7714584 1.000 rs4958842 chr5:150224877 G/A cg22134413 chr5:150180641 NA 0.67 10.07 0.37 2.97e-22 Crohn's disease; BRCA cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 26.56 0.72 2.85e-105 Chronic sinus infection; BRCA cis rs2710642 0.927 rs6705798 chr2:63259881 C/T cg17519650 chr2:63277830 OTX1 0.38 8.15 0.31 1.91e-15 LDL cholesterol levels;LDL cholesterol; BRCA cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg11890956 chr21:40555474 PSMG1 0.82 20.7 0.63 3.24e-73 Cognitive function; BRCA cis rs1506636 0.525 rs7812023 chr7:123260228 C/T cg03229431 chr7:123269106 ASB15 -0.57 -11.39 -0.41 1.76e-27 Plateletcrit;Platelet count; BRCA cis rs1267303 0.675 rs1267313 chr1:46986322 G/T cg25110126 chr1:46999211 NA -0.5 -9.53 -0.35 3.34e-20 Monobrow; BRCA cis rs6088813 1.000 rs4911178 chr20:33952620 C/T cg14752227 chr20:34000481 UQCC -0.41 -8.83 -0.33 9.99e-18 Height; BRCA trans rs7824557 0.836 rs765731 chr8:11121498 T/A cg15556689 chr8:8085844 FLJ10661 -0.41 -9.9 -0.36 1.39e-21 Retinal vascular caliber; BRCA cis rs2243480 1.000 rs4718315 chr7:65648541 T/C cg18252515 chr7:66147081 NA 1.06 16.03 0.54 7.81e-49 Diabetic kidney disease; BRCA cis rs17401966 0.931 rs746881 chr1:10346810 C/T cg19773385 chr1:10388646 KIF1B 0.38 8.21 0.31 1.26e-15 Hepatocellular carcinoma; BRCA trans rs17685 0.672 rs10952841 chr7:75778626 A/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs262150 0.851 rs2527224 chr7:158769198 G/A cg21167628 chr1:45308625 PTCH2 -0.32 -8.21 -0.31 1.24e-15 Facial morphology (factor 20); BRCA cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg21017887 chr14:105400489 NA 0.66 17.48 0.57 3.47e-56 Rheumatoid arthritis; BRCA cis rs10504229 1.000 rs58371676 chr8:58189382 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -9.84 -0.36 2.23e-21 Developmental language disorder (linguistic errors); BRCA cis rs9768139 0.733 rs35016950 chr7:158118710 C/A cg24154853 chr7:158122151 PTPRN2 0.35 8.08 0.3 3.14e-15 Calcium levels; BRCA cis rs6032067 0.673 rs6017532 chr20:43904095 C/T cg20256260 chr20:43936981 MATN4;RBPJL 0.33 8.23 0.31 1.09e-15 Blood protein levels; BRCA cis rs9324022 0.929 rs9635298 chr14:101172542 C/T cg18089426 chr14:101175970 NA 0.68 13.0 0.46 1.86e-34 Plateletcrit; BRCA cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg12386194 chr3:101231763 SENP7 0.69 12.41 0.44 7.42e-32 Colonoscopy-negative controls vs population controls; BRCA cis rs12986413 0.967 rs1015670 chr19:2171490 G/A cg09261902 chr19:2140048 AP3D1 0.38 10.06 0.37 3.37e-22 Height; BRCA cis rs2046867 0.818 rs62249862 chr3:72867949 G/C cg25664220 chr3:72788482 NA -0.55 -11.66 -0.42 1.29e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs6785206 0.667 rs6439139 chr3:128410285 T/C cg16766828 chr3:128327626 NA -0.76 -11.27 -0.41 5.43e-27 Lymphocyte percentage of white cells; BRCA cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg07395648 chr5:131743802 NA -0.35 -7.87 -0.3 1.58e-14 Breast cancer; BRCA cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg00677455 chr12:58241039 CTDSP2 0.68 15.96 0.53 1.66e-48 Intelligence (multi-trait analysis); BRCA cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg16339924 chr4:17578868 LAP3 0.62 15.46 0.52 4.66e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -12.46 -0.44 4.47e-32 Bipolar disorder and schizophrenia; BRCA cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg04455712 chr21:45112962 RRP1B -0.4 -10.98 -0.4 8.39e-26 Mean corpuscular volume; BRCA cis rs473651 0.904 rs508274 chr2:239337723 G/A cg03560586 chr2:239334908 ASB1 -0.51 -11.37 -0.41 2.17e-27 Multiple system atrophy; BRCA cis rs2153535 0.580 rs6597332 chr6:8504748 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.51 0.5 1.85e-41 Motion sickness; BRCA cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.59 0.57 9.06e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.22 0.49 4.65e-40 Motion sickness; BRCA trans rs7980799 0.935 rs10844582 chr12:33560873 A/G cg26384229 chr12:38710491 ALG10B -0.41 -8.56 -0.32 8.72e-17 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2688608 0.620 rs12253408 chr10:75495956 G/T cg23231163 chr10:75533350 FUT11 -0.33 -8.64 -0.32 4.33e-17 Inflammatory bowel disease; BRCA cis rs7914558 0.966 rs10883817 chr10:104755431 C/T cg04362960 chr10:104952993 NT5C2 0.43 10.45 0.38 1.03e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg02733842 chr7:1102375 C7orf50 -0.72 -12.47 -0.44 4.4e-32 Bronchopulmonary dysplasia; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg21280719 chr6:42927975 GNMT -0.33 -13.93 -0.48 1e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs2806561 0.765 rs605367 chr1:23518524 T/C cg12483005 chr1:23474871 LUZP1 0.43 9.45 0.35 6.12e-20 Height; BRCA cis rs6910061 1.000 rs9468415 chr6:11100885 T/A cg27233058 chr6:11094804 LOC221710 0.52 9.3 0.35 2.15e-19 Diabetic kidney disease; BRCA cis rs8114671 0.869 rs6060199 chr20:33654773 A/G cg24642439 chr20:33292090 TP53INP2 -0.42 -8.52 -0.32 1.12e-16 Height; BRCA cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg08807892 chr2:162101083 NA 0.72 16.51 0.55 2.85e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs16976116 0.901 rs28591259 chr15:55498940 T/A cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs672059 0.934 rs641057 chr1:183156859 A/G ch.1.3577855R chr1:183094577 LAMC1 0.38 8.74 0.33 2.01e-17 Hypertriglyceridemia; BRCA cis rs2652822 0.935 rs2292038 chr15:63449680 C/G cg02713581 chr15:63449717 RPS27L -0.5 -10.37 -0.38 2.25e-23 Metabolic traits; BRCA trans rs1005277 0.579 rs2474574 chr10:38387295 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg22535103 chr8:58192502 C8orf71 -0.43 -8.61 -0.32 5.71e-17 Developmental language disorder (linguistic errors); BRCA cis rs68170813 0.523 rs11762152 chr7:106811374 G/A cg02696742 chr7:106810147 HBP1 -0.52 -9.17 -0.34 6.41e-19 Coronary artery disease; BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.76 -0.42 4.88e-29 Alzheimer's disease; BRCA cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.73 -0.33 2.29e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs742320 0.756 rs3765263 chr16:840378 A/G cg02106180 chr16:845767 CHTF18 0.28 8.14 0.31 2e-15 Mean corpuscular volume; BRCA cis rs8114671 0.527 rs2253484 chr20:33405263 A/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.91 -0.33 5.29e-18 Height; BRCA cis rs1048238 0.506 rs698890 chr1:16267371 C/G cg21385522 chr1:16154831 NA -0.46 -10.02 -0.37 4.77e-22 Systolic blood pressure; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg18765753 chr7:1198926 ZFAND2A -0.49 -12.09 -0.43 1.98e-30 Longevity;Endometriosis; BRCA cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg23033748 chr14:75592666 NEK9 -0.43 -10.34 -0.38 2.92e-23 Height; BRCA cis rs10197940 0.662 rs13555 chr2:152333304 C/A cg19508488 chr2:152266495 RIF1 0.43 9.39 0.35 1.01e-19 Lung cancer; BRCA cis rs11190604 1.000 rs4919468 chr10:102288343 G/C cg07080220 chr10:102295463 HIF1AN 0.6 13.02 0.46 1.49e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg20476274 chr7:133979776 SLC35B4 0.62 17.89 0.58 2.39e-58 Mean platelet volume; BRCA trans rs1005277 0.579 rs2021649 chr10:38392122 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs9467773 1.000 rs6933176 chr6:26540178 G/A cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs250677 0.522 rs17109208 chr5:148378475 G/A cg18129178 chr5:148520854 ABLIM3 -0.55 -10.51 -0.38 6.36e-24 Breast cancer; BRCA cis rs17095355 0.818 rs59339754 chr10:111800116 C/T cg00817464 chr10:111662876 XPNPEP1 -0.44 -9.51 -0.35 3.91e-20 Biliary atresia; BRCA cis rs2777491 0.915 rs28578057 chr15:41621921 G/A cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.87 -0.48 1.89e-38 Ulcerative colitis; BRCA cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg27446573 chr6:127587934 RNF146 0.9 21.32 0.64 1.39e-76 Breast cancer; BRCA cis rs372883 0.600 rs2832293 chr21:30738872 C/G cg24692254 chr21:30365293 RNF160 0.44 9.9 0.36 1.41e-21 Pancreatic cancer; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg03188948 chr7:1209495 NA 0.44 8.84 0.33 9.58e-18 Longevity;Endometriosis; BRCA trans rs9467711 0.720 rs35627490 chr6:26462104 C/T cg01620082 chr3:125678407 NA -0.7 -8.3 -0.31 6.39e-16 Autism spectrum disorder or schizophrenia; BRCA trans rs35110281 0.807 rs28840140 chr21:45039163 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.54 0.32 9.59e-17 Mean corpuscular volume; BRCA cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03264133 chr6:25882463 NA -0.53 -11.17 -0.4 1.32e-26 Intelligence (multi-trait analysis); BRCA cis rs13064411 0.696 rs1486897 chr3:113215818 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -12.0 -0.43 4.67e-30 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs6545883 0.965 rs3771261 chr2:61762161 A/G cg15711740 chr2:61764176 XPO1 -0.54 -13.78 -0.48 5.1e-38 Tuberculosis; BRCA cis rs3733585 0.805 rs882222 chr4:9981294 G/A cg02734326 chr4:10020555 SLC2A9 0.35 7.83 0.3 2.07e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.61 -12.78 -0.45 1.82e-33 Lymphocyte counts; BRCA cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.32 0.49 1.55e-40 Motion sickness; BRCA cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.75 0.33 1.93e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3796619 1.000 rs12647929 chr4:1092019 G/T cg27284194 chr4:1044797 NA 0.43 9.29 0.35 2.35e-19 Recombination rate (males); BRCA cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg06552810 chr11:31128660 NA 0.37 8.17 0.31 1.66e-15 Red blood cell count; BRCA trans rs561341 1.000 rs510264 chr17:30323414 A/G cg27661571 chr11:113659931 NA -0.81 -12.13 -0.43 1.25e-30 Hip circumference adjusted for BMI; BRCA cis rs172166 0.694 rs536704 chr6:28092603 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.24 7.83 0.3 1.99e-14 Cardiac Troponin-T levels; BRCA cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg11843238 chr5:131593191 PDLIM4 -0.36 -7.86 -0.3 1.58e-14 Breast cancer; BRCA cis rs2243480 1.000 rs313814 chr7:65503293 C/A cg18252515 chr7:66147081 NA -0.97 -13.95 -0.48 8.76e-39 Diabetic kidney disease; BRCA cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.63 0.32 4.71e-17 Motion sickness; BRCA cis rs9814567 0.964 rs4974480 chr3:134178562 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.67 -0.32 3.44e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.57 0.76 9.6e-122 Cognitive ability; BRCA cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg22875332 chr1:76189707 ACADM 0.44 8.62 0.32 5.24e-17 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs208520 1.000 rs72882102 chr6:66983408 C/A cg07460842 chr6:66804631 NA 0.88 14.29 0.49 2.04e-40 Exhaled nitric oxide output; BRCA cis rs6570726 0.935 rs454370 chr6:145846729 T/G cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg27446573 chr6:127587934 RNF146 0.9 21.22 0.64 4.53e-76 Breast cancer; BRCA cis rs13095912 0.785 rs6791954 chr3:185335709 C/T cg11274856 chr3:185301563 NA -0.5 -12.16 -0.43 9.91e-31 Systolic blood pressure; BRCA cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg26031613 chr14:104095156 KLC1 -0.45 -8.73 -0.33 2.17e-17 Schizophrenia; BRCA cis rs4332037 0.539 rs34571717 chr7:2106855 T/C cg23422044 chr7:1970798 MAD1L1 -0.43 -8.92 -0.33 4.76e-18 Bipolar disorder; BRCA cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg01028140 chr2:1542097 TPO -0.56 -11.48 -0.41 7.52e-28 IgG glycosylation; BRCA cis rs11098499 0.754 rs12513083 chr4:120249612 A/T cg09307838 chr4:120376055 NA 0.64 14.09 0.49 1.94e-39 Corneal astigmatism; BRCA cis rs1371867 0.846 rs1660323 chr8:101278724 T/A cg06002616 chr8:101225028 SPAG1 -0.32 -7.96 -0.3 7.95e-15 Atrioventricular conduction; BRCA cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg15557168 chr22:42548783 NA 0.31 8.49 0.32 1.44e-16 Cognitive function; BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.74 0.39 7.82e-25 Tonsillectomy; BRCA cis rs1865760 0.865 rs9467650 chr6:25958235 A/G cg17691542 chr6:26056736 HIST1H1C 0.47 9.6 0.35 1.83e-20 Height; BRCA trans rs6582630 0.519 rs11519914 chr12:38287014 A/G cg06521331 chr12:34319734 NA -0.47 -9.15 -0.34 7.29e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs7851660 0.967 rs3758249 chr9:100614140 T/C cg13688889 chr9:100608707 NA -0.36 -8.71 -0.33 2.56e-17 Strep throat; BRCA cis rs61931739 0.500 rs7133447 chr12:34041901 A/G cg06521331 chr12:34319734 NA -0.58 -11.47 -0.41 7.88e-28 Morning vs. evening chronotype; BRCA cis rs7131987 0.650 rs7311912 chr12:29475703 G/C cg09582351 chr12:29534625 ERGIC2 -0.43 -9.85 -0.36 2.03e-21 QT interval; BRCA cis rs3820928 0.967 rs4675114 chr2:227768362 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.57 -0.32 7.82e-17 Pulmonary function; BRCA cis rs589448 0.933 rs523398 chr12:69752775 C/T cg20891283 chr12:69753455 YEATS4 0.84 28.19 0.74 3.23e-114 Cerebrospinal fluid biomarker levels; BRCA cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg12386194 chr3:101231763 SENP7 0.6 12.27 0.44 3.32e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 8.82e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg11266682 chr4:10021025 SLC2A9 -0.34 -8.97 -0.33 3.28e-18 Bone mineral density; BRCA cis rs7267979 0.966 rs2387885 chr20:25415224 G/A cg08601574 chr20:25228251 PYGB -0.37 -8.59 -0.32 6.76e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg24558204 chr6:135376177 HBS1L 0.53 14.79 0.51 8.65e-43 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs72772090 1.000 rs72772092 chr5:96046912 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.52 -11.42 -0.41 1.25e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs12517041 1.000 rs10059818 chr5:23292940 G/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs9486719 0.948 rs2472881 chr6:96862562 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.96e-15 Corneal astigmatism; BRCA cis rs7631605 0.935 rs6780799 chr3:37162758 G/A cg15934958 chr3:37212084 LRRFIP2 0.41 9.51 0.35 3.8e-20 Cerebrospinal P-tau181p levels; BRCA cis rs9790314 1.000 rs1382428 chr3:161032386 A/C cg04691961 chr3:161091175 C3orf57 -0.58 -13.95 -0.48 8.48e-39 Morning vs. evening chronotype; BRCA cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06022373 chr22:39101656 GTPBP1 0.71 17.71 0.57 2.24e-57 Menopause (age at onset); BRCA cis rs4664304 0.658 rs2667016 chr2:160868855 C/T cg01092293 chr2:160761427 LY75 -0.36 -8.66 -0.32 3.83e-17 Crohn's disease;Inflammatory bowel disease; BRCA cis rs999943 0.810 rs62407648 chr6:33622436 C/G cg14003231 chr6:33640908 ITPR3 0.75 16.84 0.55 6.14e-53 Obesity (extreme); BRCA cis rs7568458 1.000 rs7568458 chr2:85788175 T/A cg17127132 chr2:85788382 GGCX 0.36 8.05 0.3 4.08e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs12200782 0.505 rs1535275 chr6:26520767 G/C cg11502198 chr6:26597334 ABT1 0.64 10.36 0.38 2.43e-23 Small cell lung carcinoma; BRCA cis rs12431939 0.947 rs59298295 chr14:51659047 T/G cg23942311 chr14:51606299 NA -0.44 -8.0 -0.3 5.96e-15 Cancer; BRCA cis rs1113500 0.933 rs2077259 chr1:108629551 T/C cg06207961 chr1:108661230 NA 0.45 11.05 0.4 4.25e-26 Growth-regulated protein alpha levels; BRCA cis rs9473147 0.516 rs9395283 chr6:47551444 T/C cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.92e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs17270561 0.609 rs4712968 chr6:25760344 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs9653442 0.835 rs1561230 chr2:100746642 C/T cg22139774 chr2:100720529 AFF3 0.3 8.63 0.32 4.95e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs11051970 0.636 rs2733703 chr12:32561794 C/T cg02745156 chr12:32552066 NA 0.25 8.31 0.31 5.6e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.23e-22 Bladder cancer; BRCA cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11890956 chr21:40555474 PSMG1 0.98 23.16 0.68 1.22e-86 Cognitive function; BRCA trans rs6582630 0.555 rs10880612 chr12:38509427 A/G cg06521331 chr12:34319734 NA -0.47 -8.73 -0.33 2.14e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg25809561 chr17:30822961 MYO1D -0.37 -8.68 -0.32 3.36e-17 Schizophrenia; BRCA cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg10011062 chr15:43941034 CATSPER2 -0.55 -8.09 -0.3 2.94e-15 Lung cancer in ever smokers; BRCA cis rs12579753 0.797 rs1922561 chr12:82152640 C/A cg07988820 chr12:82153109 PPFIA2 -0.68 -11.35 -0.41 2.49e-27 Resting heart rate; BRCA cis rs910316 0.935 rs175448 chr14:75591071 G/A cg11812906 chr14:75593930 NEK9 -0.62 -14.2 -0.49 5.61e-40 Height; BRCA cis rs10911232 0.507 rs10752888 chr1:182993751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.79 0.55 1.14e-52 Hypertriglyceridemia; BRCA cis rs7737355 0.947 rs56228197 chr5:130805475 C/T cg06307176 chr5:131281290 NA -0.53 -10.55 -0.39 4.16e-24 Life satisfaction; BRCA cis rs7617773 0.817 rs11720622 chr3:48246679 G/A cg11946769 chr3:48343235 NME6 0.5 11.32 0.41 3.29e-27 Coronary artery disease; BRCA cis rs6942756 0.955 rs2056694 chr7:128923817 C/T cg02491457 chr7:128862824 NA -0.71 -14.0 -0.48 4.79e-39 White matter hyperintensity burden; BRCA cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg10876282 chr6:28092338 ZSCAN16 0.4 7.89 0.3 1.29e-14 Parkinson's disease; BRCA cis rs68170813 0.559 rs6967745 chr7:106850548 G/T cg02696742 chr7:106810147 HBP1 -0.52 -8.4 -0.32 2.81e-16 Coronary artery disease; BRCA cis rs10504229 0.683 rs16921817 chr8:58107563 A/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs367943 0.901 rs171180 chr5:112817093 A/C cg12552261 chr5:112820674 MCC -0.55 -12.21 -0.44 5.6e-31 Type 2 diabetes; BRCA cis rs4953318 1.000 rs4953318 chr2:46355051 A/C cg12428440 chr2:46370979 PRKCE 0.39 9.4 0.35 9.59e-20 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg13852791 chr20:30311386 BCL2L1 0.73 13.4 0.47 2.76e-36 Mean corpuscular hemoglobin; BRCA cis rs10189230 0.967 rs12990760 chr2:222354725 G/T cg14652038 chr2:222343519 EPHA4 0.47 13.12 0.46 5.49e-35 Urate levels in lean individuals; BRCA cis rs250677 0.522 rs891920 chr5:148369418 G/T cg12140854 chr5:148520817 ABLIM3 -0.41 -8.19 -0.31 1.38e-15 Breast cancer; BRCA cis rs3741151 0.773 rs73544710 chr11:73162273 A/G cg17517138 chr11:73019481 ARHGEF17 0.87 12.43 0.44 6.65e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -8.02 -0.3 5.08e-15 Personality dimensions; BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg08470875 chr2:26401718 FAM59B -0.64 -9.58 -0.35 2.09e-20 Gut microbiome composition (summer); BRCA cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.47 10.07 0.37 3.16e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs1005277 0.579 rs2505194 chr10:38393881 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -13.81 -0.48 3.57e-38 Extrinsic epigenetic age acceleration; BRCA cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg19274703 chr22:41806451 NA -0.35 -8.59 -0.32 6.87e-17 Vitiligo; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.81 13.35 0.47 4.89e-36 Platelet count; BRCA cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg13010199 chr12:38710504 ALG10B -0.41 -8.75 -0.33 1.95e-17 Morning vs. evening chronotype; BRCA trans rs6076960 0.629 rs6054008 chr20:6212370 C/T cg21095983 chr6:86352623 SYNCRIP 0.44 9.36 0.35 1.34e-19 Smooth-surface caries; BRCA cis rs1883415 0.534 rs2253794 chr6:24479642 C/A cg20631270 chr6:24437470 GPLD1 0.4 8.18 0.31 1.53e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg06212747 chr3:49208901 KLHDC8B 0.48 9.79 0.36 3.47e-21 Parkinson's disease; BRCA cis rs11098499 0.955 rs7685268 chr4:120162188 G/A cg09307838 chr4:120376055 NA 0.61 12.31 0.44 2.09e-31 Corneal astigmatism; BRCA cis rs1372520 0.684 rs2583968 chr4:90745395 C/G cg15133208 chr4:90757351 SNCA -0.39 -7.97 -0.3 7.48e-15 Neuroticism; BRCA cis rs1448094 0.512 rs57278040 chr12:86237886 A/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.39 -0.35 1.05e-19 Major depressive disorder; BRCA cis rs7246657 0.943 rs7255785 chr19:37971683 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.65 0.36 1.2e-20 Coronary artery calcification; BRCA cis rs12413816 0.517 rs4750400 chr10:13765923 A/G cg16485048 chr10:13749193 FRMD4A 0.44 10.89 0.4 1.85e-25 Red cell distribution width; BRCA cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg21518248 chr2:162101506 NA 0.71 17.41 0.57 7.28e-56 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs13064411 0.696 rs6798938 chr3:113218206 C/T cg18753928 chr3:113234510 CCDC52 -0.6 -12.58 -0.45 1.37e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs483180 0.512 rs1163251 chr1:120209755 T/C cg19096424 chr1:120255104 PHGDH -0.43 -9.52 -0.35 3.61e-20 Macular telangiectasia type 2; BRCA cis rs2637266 0.935 rs2252661 chr10:78404793 A/G cg18941641 chr10:78392320 NA 0.36 8.36 0.31 4.05e-16 Pulmonary function; BRCA cis rs6963495 0.818 rs55740553 chr7:105159551 A/G cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg20476274 chr7:133979776 SLC35B4 0.6 14.97 0.51 1.17e-43 Mean platelet volume; BRCA cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg05896524 chr21:47604654 C21orf56 0.42 8.04 0.3 4.33e-15 Testicular germ cell tumor; BRCA trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg03929089 chr4:120376271 NA -0.43 -8.03 -0.3 4.79e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg18230493 chr5:56204884 C5orf35 0.61 12.87 0.45 7.3e-34 Initial pursuit acceleration; BRCA cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg26818010 chr10:134567672 INPP5A 0.37 8.82 0.33 1.06e-17 Migraine; BRCA cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg27129171 chr3:47204927 SETD2 -0.71 -17.08 -0.56 3.81e-54 Colorectal cancer; BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.4 0.35 9.79e-20 Tonsillectomy; BRCA cis rs61990749 0.597 rs13379065 chr14:78141295 C/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.05 -0.37 3.59e-22 Fibroblast growth factor basic levels; BRCA cis rs7258465 1.000 rs8107367 chr19:18564705 A/G cg01065977 chr19:18549689 ISYNA1 -0.3 -9.04 -0.34 1.91e-18 Breast cancer; BRCA cis rs6446731 0.593 rs2530601 chr4:3272378 C/G cg08886695 chr4:3369023 RGS12 -0.38 -9.95 -0.37 8.78e-22 Mean platelet volume; BRCA cis rs11098499 0.569 rs10023641 chr4:120258410 C/G cg09307838 chr4:120376055 NA 0.59 12.84 0.45 1.01e-33 Corneal astigmatism; BRCA trans rs9325144 0.671 rs7485963 chr12:38768254 C/G cg23762105 chr12:34175262 ALG10 0.36 8.45 0.32 2.02e-16 Morning vs. evening chronotype; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.84 0.36 2.33e-21 Bipolar disorder; BRCA cis rs6964587 0.869 rs405 chr7:91546327 G/C cg17063962 chr7:91808500 NA -0.53 -12.08 -0.43 2.16e-30 Breast cancer; BRCA cis rs2243480 1.000 rs160643 chr7:65558222 C/T cg18252515 chr7:66147081 NA -0.89 -13.15 -0.46 3.84e-35 Diabetic kidney disease; BRCA cis rs9811920 0.535 rs792835 chr3:99476295 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.96 -0.37 8.22e-22 Axial length; BRCA cis rs7772486 0.686 rs6570701 chr6:145954090 A/G cg23711669 chr6:146136114 FBXO30 0.72 17.08 0.56 3.59e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs28595532 0.920 rs114080496 chr4:119726372 C/T cg21605333 chr4:119757512 SEC24D 1.34 13.89 0.48 1.64e-38 Cannabis dependence symptom count; BRCA cis rs801193 1.000 rs62466793 chr7:66191517 G/A cg11764359 chr7:65958608 NA 0.67 15.25 0.52 5.44e-45 Aortic root size; BRCA cis rs6942756 1.000 rs4440569 chr7:128923907 T/A cg02491457 chr7:128862824 NA -0.71 -14.01 -0.48 4.36e-39 White matter hyperintensity burden; BRCA cis rs9814567 0.896 rs11915964 chr3:134348930 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.23 0.31 1.09e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6973256 0.897 rs9656423 chr7:133324987 C/T cg07491979 chr7:133331646 EXOC4 0.39 8.88 0.33 6.54e-18 Intelligence (multi-trait analysis); BRCA cis rs13064411 0.542 rs7650671 chr3:113201216 C/T cg18753928 chr3:113234510 CCDC52 -0.41 -9.19 -0.34 5.27e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs877282 1.000 rs34257857 chr10:772993 C/A cg17470449 chr10:769945 NA 0.5 9.35 0.35 1.44e-19 Uric acid levels; BRCA cis rs11971779 0.680 rs6467840 chr7:139065401 A/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs9942416 0.660 rs17563863 chr5:74998334 G/A cg19683494 chr5:74908142 NA 0.47 8.89 0.33 6.04e-18 Age-related disease endophenotypes; BRCA trans rs11976180 1.000 rs13226728 chr7:143746578 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.42 -7.91 -0.3 1.16e-14 Obesity-related traits; BRCA cis rs1372520 0.935 rs1442152 chr4:90775649 C/A cg15133208 chr4:90757351 SNCA -0.38 -8.03 -0.3 4.61e-15 Neuroticism; BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.24 -0.41 7.23e-27 Gut microbiome composition (summer); BRCA cis rs739401 0.611 rs401707 chr11:3050965 T/C cg05729581 chr11:3078854 CARS -0.34 -8.49 -0.32 1.39e-16 Longevity; BRCA cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6582630 0.519 rs4002440 chr12:38485012 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs1577917 0.958 rs1414199 chr6:86522370 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.85 -0.42 2e-29 Response to antipsychotic treatment; BRCA cis rs847577 0.748 rs940431 chr7:97716495 C/T cg24562669 chr7:97807699 LMTK2 0.62 18.68 0.59 1.78e-62 Breast cancer; BRCA cis rs4321325 0.733 rs79995601 chr2:127947452 T/C cg11380483 chr2:127933992 NA 0.43 8.92 0.33 5.06e-18 Protein C levels; BRCA cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.4 -0.35 9.47e-20 Menopause (age at onset); BRCA cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg08558340 chr7:100472263 SRRT 0.47 7.89 0.3 1.31e-14 Resting heart rate; BRCA cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg16743903 chr16:89593216 SPG7 -0.33 -8.34 -0.31 4.44e-16 Multiple myeloma (IgH translocation); BRCA cis rs7973719 0.833 rs11044332 chr12:7358768 C/A cg07052231 chr12:7363540 PEX5 0.36 8.17 0.31 1.66e-15 IgG glycosylation; BRCA cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg24879335 chr3:133465180 TF 0.25 7.81 0.3 2.42e-14 Iron status biomarkers; BRCA cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg24838063 chr12:130822603 PIWIL1 0.69 16.86 0.55 4.77e-53 Menopause (age at onset); BRCA cis rs2832077 0.943 rs4816336 chr21:30193519 C/T cg08807101 chr21:30365312 RNF160 -0.47 -7.98 -0.3 6.73e-15 Cognitive test performance; BRCA cis rs6835098 0.962 rs6851632 chr4:174109611 A/G cg08422745 chr4:174089978 GALNT7 -0.78 -16.06 -0.54 5.51e-49 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs858239 0.730 rs858290 chr7:23248036 A/G cg23682824 chr7:23144976 KLHL7 0.31 7.98 0.3 7.03e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs7818345 0.967 rs6999786 chr8:19277817 G/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.83 0.3 1.97e-14 Language performance in older adults (adjusted for episodic memory); BRCA cis rs4268898 0.722 rs11680491 chr2:24416292 T/A cg06627628 chr2:24431161 ITSN2 0.45 9.43 0.35 7.36e-20 Asthma; BRCA cis rs61160187 0.522 rs2045356 chr5:59947354 C/T cg02684056 chr5:59996105 DEPDC1B 0.39 9.1 0.34 1.14e-18 Educational attainment (years of education);Educational attainment (college completion); BRCA cis rs2625529 0.713 rs12903980 chr15:72165549 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.41 -0.57 7.82e-56 Red blood cell count; BRCA cis rs7903847 0.642 rs11189206 chr10:99167802 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.76 -0.33 1.77e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10496034 1.000 rs2304687 chr2:55138282 C/T cg16098955 chr2:55172992 EML6 0.49 8.58 0.32 7e-17 Refractive astigmatism; BRCA cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11890956 chr21:40555474 PSMG1 0.84 21.54 0.65 9.3e-78 Cognitive function; BRCA cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.1 0.34 1.18e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg11663144 chr21:46675770 NA -0.6 -13.82 -0.48 3.24e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs701145 0.585 rs2596629 chr3:153931142 A/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs7927592 0.913 rs10896338 chr11:68299360 G/A cg20283391 chr11:68216788 NA -0.46 -8.98 -0.33 3.03e-18 Total body bone mineral density; BRCA trans rs6479891 1.000 rs4745729 chr10:65277083 A/G cg14819942 chr15:35414228 NA 0.35 8.51 0.32 1.28e-16 Arthritis (juvenile idiopathic); BRCA cis rs10752881 1.000 rs10797800 chr1:182969828 C/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.73 0.55 2.12e-52 Colorectal cancer; BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg00166722 chr3:10149974 C3orf24 0.57 10.99 0.4 7.79e-26 Alzheimer's disease; BRCA cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.69 -0.36 8.1e-21 Developmental language disorder (linguistic errors); BRCA cis rs61990749 0.597 rs717683 chr14:78255453 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.58 9.31 0.35 1.98e-19 Fibroblast growth factor basic levels; BRCA cis rs10751667 1.000 rs7395691 chr11:985006 T/C cg01483505 chr11:975446 AP2A2 0.33 8.68 0.32 3.41e-17 Alzheimer's disease (late onset); BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.2 -0.43 6.29e-31 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs12541635 0.967 rs4734896 chr8:107075454 T/C cg10147462 chr8:107024639 NA -0.31 -8.59 -0.32 6.77e-17 Age of smoking initiation; BRCA cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg21918786 chr6:109611834 NA -0.45 -12.14 -0.43 1.11e-30 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.753 rs17027308 chr4:99091088 T/A cg17366294 chr4:99064904 C4orf37 0.39 8.79 0.33 1.4e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -8.29 -0.31 6.72e-16 Alzheimer's disease (late onset); BRCA cis rs9487023 1 rs9487023 chr6:109590004 A/G cg12927641 chr6:109611667 NA -0.38 -9.31 -0.35 2.1e-19 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; BRCA trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg25214090 chr10:38739885 LOC399744 0.54 12.26 0.44 3.47e-31 Corneal astigmatism; BRCA cis rs1018836 0.851 rs12548741 chr8:91628878 G/A cg16814680 chr8:91681699 NA -0.6 -12.81 -0.45 1.32e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg12311346 chr5:56204834 C5orf35 -0.74 -14.6 -0.5 7.07e-42 Initial pursuit acceleration; BRCA cis rs10129255 0.500 rs59939897 chr14:107191651 A/G cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.69e-17 Kawasaki disease; BRCA cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg13319975 chr6:146136371 FBXO30 0.39 9.06 0.34 1.53e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg24812749 chr6:127587940 RNF146 0.87 19.82 0.62 1.62e-68 Breast cancer; BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.92 -17.22 -0.56 7.02e-55 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs6952808 0.723 rs11765550 chr7:2027324 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 8.79 0.33 1.36e-17 Bipolar disorder and schizophrenia; BRCA cis rs9381040 0.655 rs2268192 chr6:41024626 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.68 -0.36 9.11e-21 Alzheimer's disease (late onset); BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.85 -0.53 5.78e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6740322 0.895 rs6711966 chr2:43561989 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -11.77 -0.42 4.19e-29 Coronary artery disease; BRCA trans rs2204008 0.599 rs2320526 chr12:38220405 T/A cg06521331 chr12:34319734 NA -0.53 -10.02 -0.37 4.82e-22 Bladder cancer; BRCA cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.85 -0.55 5.3e-53 Extrinsic epigenetic age acceleration; BRCA cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg12927641 chr6:109611667 NA -0.39 -9.76 -0.36 4.39e-21 Reticulocyte fraction of red cells; BRCA cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.41 0.32 2.74e-16 Bladder cancer; BRCA cis rs2964802 0.505 rs2083232 chr5:10812811 G/A cg14521931 chr5:10832172 NA -0.57 -13.12 -0.46 5.59e-35 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs6430585 0.528 rs3098102 chr2:136654833 C/T cg07169764 chr2:136633963 MCM6 1.02 21.28 0.64 2.32e-76 Corneal structure; BRCA cis rs4713118 0.527 rs35949862 chr6:28115367 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Parkinson's disease; BRCA cis rs1878931 0.567 rs7196196 chr16:3411855 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.86 21.18 0.64 8.1e-76 Body mass index (adult); BRCA trans rs1973993 0.507 rs2759670 chr1:97002864 A/G cg10631902 chr5:14652156 NA 0.48 14.84 0.51 5.25e-43 Weight; BRCA cis rs6430585 0.640 rs58301703 chr2:136532225 G/A cg07169764 chr2:136633963 MCM6 1.24 26.7 0.73 4.33e-106 Corneal structure; BRCA cis rs8177253 0.530 rs8177177 chr3:133463195 A/G cg01448562 chr3:133502909 NA -0.39 -8.96 -0.33 3.53e-18 Iron status biomarkers; BRCA cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg02659138 chr7:134003124 SLC35B4 0.37 11.11 0.4 2.38e-26 Mean platelet volume; BRCA cis rs9467773 0.620 rs2451741 chr6:26629404 A/G cg09904177 chr6:26538194 HMGN4 0.46 14.64 0.5 4.45e-42 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg17971929 chr21:40555470 PSMG1 -0.49 -10.82 -0.39 3.54e-25 Menarche (age at onset); BRCA cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg17063962 chr7:91808500 NA 0.53 12.49 0.44 3.51e-32 Breast cancer; BRCA cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg00409905 chr10:38381863 ZNF37A -0.51 -10.92 -0.4 1.44e-25 Extrinsic epigenetic age acceleration; BRCA cis rs7975161 0.638 rs4592489 chr12:104619699 C/T cg25273343 chr12:104657179 TXNRD1 -0.4 -9.58 -0.35 2.04e-20 Toenail selenium levels; BRCA cis rs9325144 0.534 rs6582538 chr12:38629997 A/C cg13010199 chr12:38710504 ALG10B -0.37 -8.64 -0.32 4.33e-17 Morning vs. evening chronotype; BRCA cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg05347473 chr6:146136440 FBXO30 0.43 8.48 0.32 1.56e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg13628971 chr7:2884303 GNA12 -0.46 -9.08 -0.34 1.36e-18 Height; BRCA cis rs6089584 0.528 rs4925334 chr20:60626769 C/T cg13770153 chr20:60521292 NA -0.39 -9.17 -0.34 6.38e-19 Body mass index; BRCA cis rs709400 0.663 rs7158822 chr14:103887868 C/T cg12935359 chr14:103987150 CKB -0.58 -13.78 -0.48 5.19e-38 Body mass index; BRCA cis rs867371 0.762 rs1846910 chr15:82571780 G/A cg00614314 chr15:82944287 LOC80154 0.48 9.74 0.36 5.48e-21 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg22800045 chr5:56110881 MAP3K1 -0.47 -9.29 -0.34 2.37e-19 Initial pursuit acceleration; BRCA cis rs561341 1.000 rs530715 chr17:30320544 T/G cg23018236 chr17:30244563 NA -0.46 -8.36 -0.31 3.92e-16 Hip circumference adjusted for BMI; BRCA cis rs7264396 0.563 rs2425121 chr20:34326186 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg18279126 chr7:2041391 MAD1L1 0.37 8.21 0.31 1.22e-15 Bipolar disorder and schizophrenia; BRCA cis rs2070488 0.804 rs35463537 chr3:38498248 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.28 0.56 3.5e-55 Electrocardiographic conduction measures; BRCA cis rs7727544 0.684 rs272889 chr5:131665378 A/G cg24060327 chr5:131705240 SLC22A5 -0.46 -9.29 -0.34 2.38e-19 Blood metabolite levels; BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg25036284 chr2:26402008 FAM59B -0.9 -15.23 -0.52 6.86e-45 Gut microbiome composition (summer); BRCA cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg03477792 chr4:77819574 ANKRD56 0.61 14.83 0.51 5.6e-43 Emphysema distribution in smoking; BRCA cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg03433033 chr1:76189801 ACADM 0.67 13.55 0.47 5.82e-37 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.74e-36 Chronic sinus infection; BRCA cis rs7927771 0.524 rs10838763 chr11:47794802 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg06453172 chr10:134556979 INPP5A -0.61 -11.92 -0.43 9.85e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1971762 0.583 rs1864448 chr12:54087856 T/G cg23533419 chr12:54090519 NA -0.33 -8.3 -0.31 6.04e-16 Height; BRCA cis rs7249142 0.549 rs10854012 chr19:19295719 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -10.65 -0.39 1.77e-24 IgG glycosylation; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.94 -0.33 4.29e-18 Total body bone mineral density; BRCA cis rs9837602 1.000 rs9841186 chr3:99795651 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -11.27 -0.41 5.63e-27 Breast cancer; BRCA cis rs926392 0.932 rs6513588 chr20:37686281 T/C cg16355469 chr20:37678765 NA 0.33 8.19 0.31 1.41e-15 Dialysis-related mortality; BRCA cis rs11758351 0.925 rs10452600 chr6:26192502 C/A cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg08470875 chr2:26401718 FAM59B 0.58 9.85 0.36 2.13e-21 Gut microbiome composition (summer); BRCA cis rs11105298 0.891 rs11105309 chr12:89909850 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.7 -0.36 7.71e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9300255 0.664 rs12316131 chr12:123817796 T/C cg00376283 chr12:123451042 ABCB9 -0.49 -11.27 -0.41 5.56e-27 Neutrophil percentage of white cells; BRCA cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg03709012 chr19:19516395 GATAD2A 0.72 15.58 0.52 1.25e-46 Tonsillectomy; BRCA cis rs7044106 0.762 rs10760110 chr9:123412563 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.66 -14.25 -0.49 3.22e-40 Hip circumference adjusted for BMI; BRCA cis rs9462027 0.583 rs912716 chr6:34715761 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.05 -0.3 3.97e-15 Systemic lupus erythematosus; BRCA cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg13010199 chr12:38710504 ALG10B -0.38 -8.5 -0.32 1.32e-16 Morning vs. evening chronotype; BRCA cis rs943466 1.000 rs751096 chr6:33742838 C/T cg25922239 chr6:33757077 LEMD2 0.38 8.09 0.3 3.01e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs7949030 0.591 rs35880596 chr11:62369884 C/G cg11742103 chr11:62369870 EML3;MTA2 0.53 12.97 0.46 2.68e-34 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.29 0.44 2.66e-31 Lung cancer in ever smokers; BRCA cis rs8062405 0.824 rs62034324 chr16:28536762 T/C cg16576597 chr16:28551801 NUPR1 0.31 8.5 0.32 1.32e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2070488 0.804 rs6764551 chr3:38460305 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.63 16.62 0.55 7.71e-52 Electrocardiographic conduction measures; BRCA cis rs3784262 0.765 rs8026952 chr15:58276950 C/A cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.27 -0.38 5.13e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11098499 0.909 rs28884220 chr4:120307211 A/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs4713118 0.662 rs149946 chr6:27970031 A/C cg02631126 chr6:28058918 ZSCAN12L1 -0.27 -7.86 -0.3 1.69e-14 Parkinson's disease; BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.27 -0.34 2.71e-19 Total body bone mineral density; BRCA cis rs16958440 1.000 rs62096471 chr18:44643814 T/C cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs7582180 0.564 rs2309795 chr2:100954290 G/A cg14675211 chr2:100938903 LONRF2 0.45 10.26 0.38 5.77e-23 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg04025307 chr7:1156635 C7orf50 0.71 17.84 0.58 4.58e-58 Longevity;Endometriosis; BRCA cis rs6977660 0.714 rs728156 chr7:19826309 G/C cg07541023 chr7:19748670 TWISTNB 0.55 9.56 0.35 2.41e-20 Thyroid stimulating hormone; BRCA cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.87 0.42 1.71e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs798766 0.903 rs798726 chr4:1685211 C/T cg10756475 chr4:1757242 NA -0.38 -8.72 -0.33 2.43e-17 Bladder cancer;Urinary bladder cancer; BRCA cis rs11249608 0.548 rs6859936 chr5:178451214 T/C cg21905437 chr5:178450457 ZNF879 0.53 10.99 0.4 7.14e-26 Pubertal anthropometrics; BRCA cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.02 0.4 5.6e-26 Bipolar disorder; BRCA trans rs9329221 0.662 rs11249996 chr8:10245463 G/T cg06636001 chr8:8085503 FLJ10661 -0.5 -9.95 -0.37 8.43e-22 Neuroticism; BRCA cis rs2742234 0.955 rs2435384 chr10:43673731 G/T cg02780029 chr10:43622663 RET -0.39 -9.59 -0.35 1.95e-20 Hirschsprung disease; BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg10729496 chr3:10149963 C3orf24 0.49 9.41 0.35 8.99e-20 Alzheimer's disease; BRCA cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg21535247 chr6:8435926 SLC35B3 0.39 8.65 0.32 4.14e-17 Motion sickness; BRCA cis rs367943 0.871 rs348938 chr5:112825032 C/A cg12552261 chr5:112820674 MCC -0.46 -10.43 -0.38 1.25e-23 Type 2 diabetes; BRCA cis rs4906332 1.000 rs11625172 chr14:103944912 G/A cg04998671 chr14:104000505 TRMT61A -0.43 -9.5 -0.35 4.27e-20 Coronary artery disease; BRCA cis rs2806561 1.000 rs1757048 chr1:23510601 A/C cg19743168 chr1:23544995 NA 0.42 10.25 0.38 6.4e-23 Height; BRCA cis rs3820928 0.839 rs10197773 chr2:227824835 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -8.94 -0.33 4.3e-18 Pulmonary function; BRCA cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs561341 0.556 rs542244 chr17:30307242 T/C cg27661571 chr11:113659931 NA -0.69 -10.72 -0.39 8.84e-25 Hip circumference adjusted for BMI; BRCA cis rs7264396 0.733 rs6058305 chr20:34310757 C/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.22 0.31 1.13e-15 Total cholesterol levels; BRCA cis rs2180341 0.781 rs7742161 chr6:127571676 T/C cg24812749 chr6:127587940 RNF146 0.7 15.23 0.52 6.71e-45 Breast cancer; BRCA cis rs11105298 0.891 rs8181784 chr12:89828591 A/G cg00757033 chr12:89920650 WDR51B 0.44 9.54 0.35 2.85e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg06453172 chr10:134556979 INPP5A -0.55 -11.5 -0.41 5.87e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10911232 0.507 rs6672306 chr1:183058898 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.74 0.55 2.04e-52 Hypertriglyceridemia; BRCA cis rs9291683 0.588 rs17246745 chr4:9994583 T/C cg02734326 chr4:10020555 SLC2A9 0.39 8.57 0.32 7.62e-17 Bone mineral density; BRCA cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg15605315 chr1:45957053 TESK2 0.49 10.11 0.37 2.11e-22 High light scatter reticulocyte count; BRCA cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg19010396 chr19:19431384 KIAA0892;SF4 0.49 9.73 0.36 6.05e-21 Tonsillectomy; BRCA cis rs7945705 0.818 rs2653613 chr11:8879105 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.06 -0.49 2.59e-39 Hemoglobin concentration; BRCA cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg06618935 chr21:46677482 NA -0.36 -8.01 -0.3 5.55e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg11663144 chr21:46675770 NA -0.61 -14.35 -0.49 1.16e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs66887589 0.870 rs59590064 chr4:120539753 T/C cg09307838 chr4:120376055 NA -0.44 -9.13 -0.34 8.58e-19 Diastolic blood pressure; BRCA cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4919087 0.962 rs10882883 chr10:99013312 A/G cg25902810 chr10:99078978 FRAT1 0.43 9.15 0.34 7.66e-19 Monocyte count; BRCA cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg13944838 chr5:179740914 GFPT2 -0.68 -14.41 -0.5 5.43e-41 Height; BRCA cis rs10191773 0.535 rs11685514 chr2:113100014 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.61 8.52 0.32 1.17e-16 Yeast infection; BRCA cis rs3857067 0.806 rs7678054 chr4:95093855 A/G cg11021082 chr4:95130006 SMARCAD1 0.39 8.99 0.33 2.88e-18 QT interval; BRCA cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.36 13.47 0.47 1.33e-36 Autism spectrum disorder or schizophrenia; BRCA cis rs1538970 0.816 rs9727262 chr1:45998579 T/G cg05343316 chr1:45956843 TESK2 0.7 14.24 0.49 3.83e-40 Platelet count; BRCA cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg09469691 chr10:81107165 PPIF 0.49 10.3 0.38 4.02e-23 Height; BRCA cis rs7100689 0.542 rs10887869 chr10:82194689 A/G cg01528321 chr10:82214614 TSPAN14 0.72 16.31 0.54 2.85e-50 Post bronchodilator FEV1; BRCA cis rs10496034 1.000 rs1012603 chr2:55274531 C/T cg16098955 chr2:55172992 EML6 0.51 8.21 0.31 1.27e-15 Refractive astigmatism; BRCA cis rs11051970 0.545 rs2651375 chr12:32582652 G/T cg24626660 chr12:32551988 NA -0.3 -8.97 -0.33 3.27e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg17063962 chr7:91808500 NA 0.53 12.53 0.44 2.32e-32 Breast cancer; BRCA cis rs1776421 0.760 rs61768414 chr1:53906995 C/T cg10892335 chr1:53966318 NA 0.5 8.36 0.31 3.8e-16 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs9486719 0.895 rs12195315 chr6:96905711 T/G cg06623918 chr6:96969491 KIAA0776 -0.72 -12.99 -0.46 2.14e-34 Migraine;Coronary artery disease; BRCA cis rs6060717 0.536 rs11696912 chr20:34497660 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.57 8.0 0.3 5.97e-15 Hip circumference adjusted for BMI; BRCA trans rs7618501 0.521 rs952594 chr3:49908023 G/A cg21659725 chr3:3221576 CRBN 0.37 9.09 0.34 1.27e-18 Intelligence (multi-trait analysis); BRCA cis rs877282 0.898 rs11253344 chr10:765162 C/T cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA cis rs9837602 0.810 rs13093776 chr3:99842140 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.44 8.13 0.31 2.29e-15 Breast cancer; BRCA cis rs453301 0.606 rs6601279 chr8:8908231 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -9.79 -0.36 3.43e-21 Joint mobility (Beighton score); BRCA cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg02734326 chr4:10020555 SLC2A9 0.41 8.83 0.33 9.81e-18 Bone mineral density; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs473651 0.935 rs559579 chr2:239339501 G/C cg03560586 chr2:239334908 ASB1 -0.41 -7.87 -0.3 1.55e-14 Multiple system atrophy; BRCA cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg24112000 chr20:60950667 NA -0.53 -10.04 -0.37 4.01e-22 Colorectal cancer; BRCA cis rs17270561 0.609 rs2000351 chr6:25759783 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 22.01 0.66 2.4e-80 Platelet count; BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg05025164 chr4:1340916 KIAA1530 0.51 10.83 0.39 3.2e-25 Longevity; BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg22920501 chr2:26401640 FAM59B 0.93 16.09 0.54 3.86e-49 Mean corpuscular hemoglobin; BRCA cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg06238570 chr21:40685208 BRWD1 -0.42 -8.52 -0.32 1.19e-16 Cognitive function; BRCA cis rs77106637 1.000 rs11602858 chr11:72615069 C/G cg03713592 chr11:72463424 ARAP1 0.79 11.63 0.42 1.69e-28 Type 2 diabetes; BRCA cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg16179182 chr5:140090404 VTRNA1-1 0.44 10.4 0.38 1.6e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg06784218 chr1:46089804 CCDC17 0.5 12.17 0.43 8.36e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7246657 0.722 rs3101746 chr19:38146400 T/A cg23950597 chr19:37808831 NA 0.51 8.72 0.33 2.42e-17 Coronary artery calcification; BRCA trans rs61931739 0.513 rs10772116 chr12:33897795 G/C cg13010199 chr12:38710504 ALG10B 0.37 8.12 0.31 2.49e-15 Morning vs. evening chronotype; BRCA cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg13902645 chr11:5959945 NA -0.56 -11.34 -0.41 2.65e-27 DNA methylation (variation); BRCA cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.97 0.3 7.55e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs965469 0.895 rs6051729 chr20:3290615 A/G cg25506879 chr20:3388711 C20orf194 -0.49 -9.72 -0.36 6.34e-21 IFN-related cytopenia; BRCA cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg18850127 chr7:39170497 POU6F2 0.45 10.19 0.37 1.04e-22 IgG glycosylation; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg08470875 chr2:26401718 FAM59B -0.72 -11.89 -0.43 1.31e-29 Gut microbiome composition (summer); BRCA cis rs9549260 0.564 rs9646110 chr13:41308301 A/T cg21288729 chr13:41239152 FOXO1 -0.49 -10.13 -0.37 1.76e-22 Red blood cell count; BRCA cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg11502198 chr6:26597334 ABT1 -0.48 -9.56 -0.35 2.6e-20 Intelligence (multi-trait analysis); BRCA cis rs6723226 0.708 rs2710627 chr2:32758627 A/G cg02381751 chr2:32503542 YIPF4 0.64 13.91 0.48 1.24e-38 Intelligence (multi-trait analysis); BRCA cis rs1577917 0.958 rs12208227 chr6:86670944 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.36 -0.44 1.26e-31 Response to antipsychotic treatment; BRCA cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg03433033 chr1:76189801 ACADM -0.76 -17.43 -0.57 5.73e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs652260 1.000 rs652260 chr19:7900562 C/T cg26014689 chr19:7917955 EVI5L -0.52 -11.7 -0.42 8.98e-29 Menarche (age at onset); BRCA cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.56 0.5 1.14e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.747 rs4845333 chr1:152982877 G/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.82e-16 Inflammatory skin disease; BRCA cis rs7666738 0.680 rs11097613 chr4:99079991 G/T cg17366294 chr4:99064904 C4orf37 0.42 9.51 0.35 3.85e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs61931739 0.517 rs7958755 chr12:34294699 T/C cg06521331 chr12:34319734 NA -0.65 -11.99 -0.43 5.28e-30 Morning vs. evening chronotype; BRCA cis rs4664304 0.620 rs10186586 chr2:160715334 T/C cg02280532 chr2:160761244 LY75 0.35 7.81 0.3 2.4e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs35306767 0.953 rs35174953 chr10:961191 C/A cg25019033 chr10:957182 NA -0.43 -8.81 -0.33 1.21e-17 Eosinophil percentage of granulocytes; BRCA cis rs4919087 1.000 rs11189127 chr10:99079023 G/A cg25902810 chr10:99078978 FRAT1 0.52 11.44 0.41 1.09e-27 Monocyte count; BRCA cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg21747090 chr2:27597821 SNX17 -0.38 -8.38 -0.31 3.49e-16 Total body bone mineral density; BRCA cis rs849141 0.890 rs481806 chr7:28207300 G/T cg22892036 chr7:28189139 JAZF1 0.46 8.32 0.31 5.14e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs7178424 0.967 rs11639482 chr15:62282114 C/T cg00456672 chr15:62358751 C2CD4A -0.38 -8.74 -0.33 2.04e-17 Height; BRCA cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg01877450 chr7:97915802 BRI3 0.4 9.12 0.34 9.59e-19 Prostate cancer (SNP x SNP interaction); BRCA cis rs9359856 0.510 rs3736984 chr6:90408589 C/T cg13799429 chr6:90582589 CASP8AP2 0.7 10.71 0.39 1.01e-24 Bipolar disorder; BRCA cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Bladder cancer; BRCA cis rs9790314 0.540 rs35462273 chr3:160991877 C/T cg03342759 chr3:160939853 NMD3 -0.8 -17.95 -0.58 1.2e-58 Morning vs. evening chronotype; BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg13047869 chr3:10149882 C3orf24 0.59 12.27 0.44 3.13e-31 Alzheimer's disease; BRCA cis rs6952809 0.532 rs6952152 chr7:2440912 G/A cg23289794 chr7:2394357 EIF3B -0.64 -11.99 -0.43 5.32e-30 Multiple sclerosis; BRCA cis rs6062302 0.522 rs13043255 chr20:62218916 C/G cg16989086 chr20:62203971 PRIC285 0.53 8.9 0.33 5.65e-18 Glioblastoma; BRCA cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg10802521 chr3:52805072 NEK4 -0.32 -8.53 -0.32 1.09e-16 Electroencephalogram traits; BRCA cis rs35146811 0.586 rs12705067 chr7:99594726 T/C cg13334819 chr7:99746414 C7orf59 -0.35 -8.03 -0.3 4.65e-15 Coronary artery disease; BRCA cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03934478 chr11:495069 RNH1 0.84 13.02 0.46 1.47e-34 Body mass index; BRCA cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg16325326 chr1:53192061 ZYG11B -0.66 -16.27 -0.54 4.55e-50 Monocyte count; BRCA cis rs2075671 0.903 rs62482252 chr7:100274063 C/A cg20848291 chr7:100343083 ZAN -0.62 -12.72 -0.45 3.44e-33 Other erythrocyte phenotypes; BRCA cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg08027265 chr7:2291960 NA -0.34 -8.48 -0.32 1.61e-16 Schizophrenia; BRCA cis rs921968 0.565 rs4674330 chr2:219595710 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.07 -0.4 3.48e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9649213 0.533 rs62478235 chr7:98030349 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.6 -15.79 -0.53 1.21e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg00080972 chr5:178986291 RUFY1 0.5 12.64 0.45 7.38e-33 Lung cancer; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg13047869 chr3:10149882 C3orf24 0.54 10.1 0.37 2.34e-22 Alzheimer's disease; BRCA cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg10932868 chr11:921992 NA 0.5 12.76 0.45 2.15e-33 Alzheimer's disease (late onset); BRCA cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg03452623 chr4:187889614 NA -0.31 -10.01 -0.37 5.07e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg11764359 chr7:65958608 NA -0.71 -15.17 -0.51 1.32e-44 Aortic root size; BRCA cis rs637571 0.522 rs12792888 chr11:65761446 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.63 13.48 0.47 1.27e-36 Eosinophil percentage of white cells; BRCA cis rs4481887 0.893 rs10888355 chr1:248457180 G/A cg13385794 chr1:248469461 NA 0.29 7.88 0.3 1.44e-14 Common traits (Other); BRCA cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.74 -0.42 5.93e-29 Electroencephalogram traits; BRCA cis rs9790314 1.000 rs1600209 chr3:161038217 A/T cg03342759 chr3:160939853 NMD3 -0.64 -13.56 -0.47 5.21e-37 Morning vs. evening chronotype; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg18402987 chr7:1209562 NA 0.66 11.29 0.41 4.66e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7618501 0.521 rs34654589 chr3:49911449 C/G cg05623727 chr3:50126028 RBM5 0.51 12.1 0.43 1.64e-30 Intelligence (multi-trait analysis); BRCA cis rs4660306 1.000 rs7522705 chr1:45992300 C/G cg24296786 chr1:45957014 TESK2 -0.48 -10.01 -0.37 5.38e-22 Homocysteine levels; BRCA cis rs908922 0.584 rs10888500 chr1:152532749 G/A cg20991723 chr1:152506922 NA 0.35 7.89 0.3 1.33e-14 Hair morphology; BRCA cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg18904891 chr8:8559673 CLDN23 0.6 11.68 0.42 1.02e-28 Obesity-related traits; BRCA cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg19678392 chr7:94953810 PON1 -0.42 -8.62 -0.32 5.29e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg21782813 chr7:2030301 MAD1L1 0.32 9.17 0.34 6.18e-19 Schizophrenia; BRCA cis rs34779708 0.733 rs12243593 chr10:35549045 C/T cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg04315214 chr1:2043799 PRKCZ -0.44 -12.14 -0.43 1.18e-30 Height; BRCA cis rs4713118 0.587 rs61471148 chr6:28037032 T/A cg18032046 chr6:28092343 ZSCAN16 -0.49 -8.01 -0.3 5.28e-15 Parkinson's disease; BRCA cis rs6860806 0.507 rs273912 chr5:131661349 A/C cg07395648 chr5:131743802 NA 0.38 8.37 0.31 3.67e-16 Breast cancer; BRCA cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg05347473 chr6:146136440 FBXO30 0.41 8.27 0.31 7.88e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg21573476 chr21:45109991 RRP1B -0.48 -12.13 -0.43 1.24e-30 Mean corpuscular volume; BRCA cis rs7760949 0.889 rs9396272 chr6:13938080 C/T cg27413430 chr6:13925136 RNF182 -0.42 -8.45 -0.32 1.92e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs4478858 0.684 rs12121165 chr1:31725542 G/A cg00250761 chr1:31883323 NA -0.32 -8.3 -0.31 6.08e-16 Alcohol dependence; BRCA cis rs9733 0.519 rs6700022 chr1:150670484 G/T cg17724175 chr1:150552817 MCL1 -0.25 -8.36 -0.31 3.94e-16 Tonsillectomy; BRCA cis rs2921036 0.529 rs2979192 chr8:8338147 C/T cg08975724 chr8:8085496 FLJ10661 0.43 8.52 0.32 1.16e-16 Neuroticism; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg10150615 chr22:24372951 LOC391322 -0.45 -10.27 -0.38 5.38e-23 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.26 -0.31 8.38e-16 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.95 0.43 7.45e-30 Tonsillectomy; BRCA cis rs7301826 0.651 rs10848210 chr12:131312020 G/A cg11011512 chr12:131303247 STX2 0.52 13.72 0.48 9.48e-38 Plasma plasminogen activator levels; BRCA cis rs9359856 0.564 rs72915904 chr6:90421412 C/A cg13799429 chr6:90582589 CASP8AP2 -0.65 -8.08 -0.3 3.14e-15 Bipolar disorder; BRCA cis rs35123781 1.000 rs600848 chr5:139057270 T/C cg05227215 chr5:139057496 CXXC5 0.35 8.42 0.32 2.46e-16 Schizophrenia; BRCA cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg06697600 chr4:7070879 GRPEL1 0.49 8.83 0.33 9.92e-18 Monocyte percentage of white cells; BRCA cis rs875971 0.862 rs2901152 chr7:65765004 G/A cg11764359 chr7:65958608 NA -0.75 -16.73 -0.55 2.18e-52 Aortic root size; BRCA cis rs2463822 1.000 rs2463825 chr11:62094493 G/A cg06239285 chr11:62104954 ASRGL1 0.66 11.05 0.4 4.1e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs250677 0.687 rs36043 chr5:148440983 G/A cg23229984 chr5:148520753 ABLIM3 0.37 9.17 0.34 6.47e-19 Breast cancer; BRCA cis rs317689 0.718 rs315122 chr12:69771073 G/T cg20891283 chr12:69753455 YEATS4 0.56 11.38 0.41 1.82e-27 Response to diuretic therapy; BRCA cis rs11608355 0.545 rs7316375 chr12:109906998 G/C cg05360138 chr12:110035743 NA 0.69 12.79 0.45 1.72e-33 Neuroticism; BRCA cis rs7918232 0.882 rs10829190 chr10:27409555 C/T cg14240646 chr10:27532245 ACBD5 -0.62 -9.56 -0.35 2.58e-20 Breast cancer; BRCA cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg03146154 chr1:46216737 IPP 0.45 10.1 0.37 2.28e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3740540 0.685 rs61870248 chr10:126267523 T/C cg04949429 chr10:126290192 LHPP -0.38 -7.99 -0.3 6.54e-15 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs7582180 0.676 rs11680660 chr2:100931738 G/C cg14675211 chr2:100938903 LONRF2 0.48 11.05 0.4 4.14e-26 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg22920501 chr2:26401640 FAM59B -0.67 -11.5 -0.41 5.96e-28 Gut microbiome composition (summer); BRCA trans rs7395662 0.504 rs1814158 chr11:48437937 C/T cg00717180 chr2:96193071 NA -0.38 -10.23 -0.38 7.55e-23 HDL cholesterol; BRCA cis rs9790314 1.000 rs28515190 chr3:161028605 G/A cg03342759 chr3:160939853 NMD3 -0.63 -13.45 -0.47 1.75e-36 Morning vs. evening chronotype; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg22907277 chr7:1156413 C7orf50 0.61 11.9 0.43 1.25e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg11608241 chr8:8085544 FLJ10661 0.28 7.82 0.3 2.19e-14 Mood instability; BRCA cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.01e-15 Alzheimer's disease (late onset); BRCA cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs9393777 0.528 rs35982103 chr6:27243134 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.22 -0.31 1.12e-15 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.41 0.44 8.15e-32 Platelet count; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 18.98 0.6 4.6e-64 Platelet count; BRCA cis rs7659604 0.539 rs3217773 chr4:122739121 A/G cg19748678 chr4:122722346 EXOSC9 0.74 16.02 0.54 8.68e-49 Type 2 diabetes; BRCA cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.35 -0.31 4.34e-16 Colorectal cancer; BRCA cis rs644148 0.836 rs2686776 chr19:45000366 T/C cg15540054 chr19:45004280 ZNF180 -0.57 -12.28 -0.44 2.76e-31 Personality dimensions; BRCA cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.37e-39 Initial pursuit acceleration; BRCA cis rs11190604 1.000 rs17113137 chr10:102241998 G/C cg07080220 chr10:102295463 HIF1AN 0.5 11.25 0.41 6.35e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1215050 0.791 rs983187 chr4:98816350 A/T cg05340658 chr4:99064831 C4orf37 0.45 10.16 0.37 1.34e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs1003719 0.762 rs11701556 chr21:38455153 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.18 0.49 7.08e-40 Eye color traits; BRCA cis rs10876993 0.890 rs12302351 chr12:58062590 T/C cg18357645 chr12:58087776 OS9 0.41 11.43 0.41 1.16e-27 Celiac disease or Rheumatoid arthritis; BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg16812893 chr21:31813075 KRTAP15-1 0.37 9.4 0.35 9.41e-20 HDL cholesterol; BRCA cis rs9309473 0.500 rs12996463 chr2:73655496 T/C cg20560298 chr2:73613845 ALMS1 0.42 11.45 0.41 9.23e-28 Metabolite levels; BRCA cis rs7647973 0.626 rs1491985 chr3:49739507 G/C cg03060546 chr3:49711283 APEH 0.59 10.36 0.38 2.36e-23 Menarche (age at onset); BRCA cis rs1784581 0.761 rs7741581 chr6:162435250 C/T cg17173639 chr6:162384350 PARK2 0.37 8.79 0.33 1.38e-17 Itch intensity from mosquito bite; BRCA cis rs2115630 1.000 rs1030863 chr15:85282635 C/T cg11189052 chr15:85197271 WDR73 -0.33 -7.89 -0.3 1.35e-14 P wave terminal force; BRCA cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg11764359 chr7:65958608 NA -0.62 -13.14 -0.46 4.35e-35 Aortic root size; BRCA cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.22 -0.31 1.16e-15 Axial length; BRCA cis rs875971 0.638 rs801205 chr7:66022144 C/A cg18876405 chr7:65276391 NA -0.62 -15.48 -0.52 3.8e-46 Aortic root size; BRCA cis rs11887277 0.507 rs7602471 chr2:27050727 G/A cg12368169 chr2:27073192 DPYSL5 -0.28 -8.06 -0.3 3.76e-15 Obesity-related traits; BRCA cis rs17401966 0.894 rs12722830 chr1:10395134 A/G cg03954927 chr1:10346856 KIF1B 0.48 15.23 0.52 6.45e-45 Hepatocellular carcinoma; BRCA cis rs6433857 0.536 rs7557023 chr2:181350474 G/A cg23363182 chr2:181467187 NA -0.37 -7.87 -0.3 1.57e-14 Body mass index; BRCA cis rs3008870 0.755 rs10749766 chr1:67376921 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.69 0.48 1.36e-37 Lymphocyte percentage of white cells; BRCA cis rs40363 0.645 rs250633 chr16:3523002 C/T cg22508957 chr16:3507546 NAT15 0.47 11.59 0.42 2.53e-28 Tuberculosis; BRCA cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6547741 1.000 rs10205364 chr2:27794233 C/T cg27432699 chr2:27873401 GPN1 0.46 9.7 0.36 7.89e-21 Oral cavity cancer; BRCA cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.6 -0.39 2.81e-24 Menarche (age at onset); BRCA cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.13 0.37 1.82e-22 Aortic root size; BRCA trans rs1493916 1.000 rs12457802 chr18:31389865 A/G cg27147174 chr7:100797783 AP1S1 0.52 10.47 0.38 8.96e-24 Life satisfaction; BRCA cis rs9527 0.590 rs7087040 chr10:104799668 G/A cg04362960 chr10:104952993 NT5C2 0.43 9.84 0.36 2.32e-21 Arsenic metabolism; BRCA cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg11366901 chr6:160182831 ACAT2 0.86 16.32 0.54 2.59e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs9486719 1.000 rs2092096 chr6:96870919 A/G cg06623918 chr6:96969491 KIAA0776 0.71 12.75 0.45 2.44e-33 Migraine;Coronary artery disease; BRCA cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg07636037 chr3:49044803 WDR6 0.97 28.33 0.75 5.26e-115 Parkinson's disease; BRCA cis rs9814567 1.000 rs1917130 chr3:134313773 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.76 0.33 1.78e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6426558 0.537 rs2813969 chr1:227404082 T/C cg10327440 chr1:227177885 CDC42BPA 0.46 9.18 0.34 5.86e-19 Neutrophil percentage of white cells; BRCA trans rs61931739 0.591 rs4931764 chr12:33979423 A/G cg26384229 chr12:38710491 ALG10B 0.4 8.94 0.33 4.07e-18 Morning vs. evening chronotype; BRCA cis rs10465746 0.780 rs12145258 chr1:84401211 G/A cg10977910 chr1:84465055 TTLL7 0.57 11.87 0.42 1.7e-29 Obesity-related traits; BRCA cis rs12711979 0.509 rs10192699 chr2:3824297 A/G cg17052675 chr2:3827356 NA -0.7 -23.65 -0.68 2.6e-89 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs2066819 1.000 rs77447765 chr12:56690662 G/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs10504229 0.679 rs17804870 chr8:58158071 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -8.59 -0.32 6.79e-17 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs208520 0.837 rs208471 chr6:66916749 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.3 -0.54 3.22e-50 Exhaled nitric oxide output; BRCA cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.17 -0.37 1.24e-22 Initial pursuit acceleration; BRCA cis rs8062405 0.895 rs56186137 chr16:28825953 A/G cg09754948 chr16:28834200 ATXN2L 0.45 9.03 0.34 2.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg06784218 chr1:46089804 CCDC17 0.52 12.56 0.44 1.72e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6545883 0.929 rs1209434 chr2:61672958 G/A cg15711740 chr2:61764176 XPO1 -0.53 -13.35 -0.47 4.87e-36 Tuberculosis; BRCA cis rs3008870 0.755 rs2208577 chr1:67513574 A/C cg02640540 chr1:67518911 SLC35D1 0.51 11.21 0.41 9.92e-27 Lymphocyte percentage of white cells; BRCA cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs490234 0.932 rs577026 chr9:128341023 C/T cg14078157 chr9:128172775 NA -0.38 -9.2 -0.34 5.19e-19 Mean arterial pressure; BRCA cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg02659138 chr7:134003124 SLC35B4 0.4 11.58 0.42 2.85e-28 Mean platelet volume; BRCA cis rs4237845 0.537 rs12426201 chr12:58259752 C/T cg00677455 chr12:58241039 CTDSP2 0.7 16.32 0.54 2.75e-50 Intelligence (multi-trait analysis); BRCA cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg27446573 chr6:127587934 RNF146 0.78 17.09 0.56 3.21e-54 Breast cancer; BRCA cis rs3750965 0.920 rs10896421 chr11:68863048 T/C cg06818126 chr11:68850279 TPCN2 -0.37 -8.86 -0.33 7.61e-18 Hair color; BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.62 -0.32 5.4e-17 Total body bone mineral density; BRCA cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg23018236 chr17:30244563 NA -0.71 -11.06 -0.4 3.71e-26 Hip circumference adjusted for BMI; BRCA cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg22535103 chr8:58192502 C8orf71 -0.6 -13.26 -0.46 1.29e-35 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.39 0.35 1e-19 Tonsillectomy; BRCA cis rs34779708 0.771 rs12098283 chr10:35478115 G/T cg03585969 chr10:35415529 CREM 0.48 10.03 0.37 4.52e-22 Inflammatory bowel disease;Crohn's disease; BRCA trans rs877282 0.786 rs10904558 chr10:797509 C/T cg22713356 chr15:30763199 NA 1.37 28.02 0.74 2.84e-113 Uric acid levels; BRCA cis rs6543140 0.929 rs11465700 chr2:103057668 G/A cg04239558 chr2:103089729 SLC9A4 0.34 9.41 0.35 8.88e-20 Blood protein levels; BRCA cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs1538970 0.924 rs2088100 chr1:45877575 C/T cg05343316 chr1:45956843 TESK2 0.63 12.76 0.45 2.21e-33 Platelet count; BRCA cis rs9790314 0.934 rs461638 chr3:161103166 A/G cg04691961 chr3:161091175 C3orf57 -0.53 -12.38 -0.44 1.08e-31 Morning vs. evening chronotype; BRCA trans rs877282 0.898 rs36064821 chr10:760952 C/T cg22713356 chr15:30763199 NA 1.29 24.18 0.69 3.39e-92 Uric acid levels; BRCA cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg20887711 chr4:1340912 KIAA1530 -0.7 -15.64 -0.53 6.52e-47 Longevity; BRCA trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg26384229 chr12:38710491 ALG10B 0.57 13.16 0.46 3.66e-35 Morning vs. evening chronotype; BRCA cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11890956 chr21:40555474 PSMG1 -0.65 -14.8 -0.51 7.6e-43 Menarche (age at onset); BRCA trans rs8002861 0.664 rs2325089 chr13:44450222 C/G cg17145862 chr1:211918768 LPGAT1 -0.46 -10.67 -0.39 1.46e-24 Leprosy; BRCA cis rs6450176 1.000 rs3776717 chr5:53298762 G/A ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs6546550 0.901 rs10496174 chr2:70153436 T/G cg02498382 chr2:70120550 SNRNP27 -0.51 -11.12 -0.4 2.26e-26 Prevalent atrial fibrillation; BRCA cis rs7264396 0.943 rs11167267 chr20:34109273 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -7.84 -0.3 1.96e-14 Total cholesterol levels; BRCA cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg21573476 chr21:45109991 RRP1B -0.36 -9.48 -0.35 4.75e-20 Mean corpuscular volume; BRCA cis rs9814567 0.806 rs9841371 chr3:134320765 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6964587 0.967 rs6974827 chr7:91772945 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.11 0.31 2.58e-15 Breast cancer; BRCA cis rs561341 0.882 rs2521594 chr17:30302087 C/T cg23018236 chr17:30244563 NA -0.61 -10.04 -0.37 4.1e-22 Hip circumference adjusted for BMI; BRCA cis rs992157 0.560 rs6738394 chr2:219110625 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.27 -0.34 2.75e-19 Colorectal cancer; BRCA cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA trans rs6601450 0.522 rs7837979 chr8:10198534 C/T cg06636001 chr8:8085503 FLJ10661 0.49 10.45 0.38 1.01e-23 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.58 0.55 1.23e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs4594175 0.926 rs11157803 chr14:51627700 C/T cg23942311 chr14:51606299 NA 0.32 8.22 0.31 1.16e-15 Cancer; BRCA cis rs1707322 0.686 rs2152078 chr1:46055600 C/T cg03146154 chr1:46216737 IPP -0.49 -10.82 -0.39 3.59e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg08000102 chr2:233561755 GIGYF2 0.63 13.47 0.47 1.35e-36 Coronary artery disease; BRCA cis rs2455601 0.638 rs2742484 chr11:8988083 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.43 -7.97 -0.3 7.19e-15 Schizophrenia; BRCA cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg08601574 chr20:25228251 PYGB 0.34 8.32 0.31 5.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7258465 1.000 rs10409505 chr19:18590251 C/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.35 -0.31 4.35e-16 Breast cancer; BRCA cis rs1997103 1.000 rs1997103 chr7:55395390 C/G cg17469321 chr7:55412551 NA 0.49 9.25 0.34 3.45e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg20933634 chr6:27740509 NA 0.45 9.01 0.34 2.3e-18 Parkinson's disease; BRCA cis rs4588572 0.606 rs4290994 chr5:77742253 C/T cg11547950 chr5:77652471 NA -0.42 -8.04 -0.3 4.5e-15 Triglycerides; BRCA cis rs796364 1.000 rs71424239 chr2:200725473 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.79 -11.29 -0.41 4.28e-27 Schizophrenia; BRCA cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg08213375 chr14:104286397 PPP1R13B 0.63 17.07 0.56 4.11e-54 Schizophrenia; BRCA cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.02 0.37 4.78e-22 Bipolar disorder; BRCA cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg04511125 chr2:88470314 THNSL2 0.92 13.36 0.47 4.43e-36 Plasma clusterin levels; BRCA cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg02187348 chr16:89574699 SPG7 0.43 9.89 0.36 1.52e-21 Multiple myeloma (IgH translocation); BRCA cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.49e-52 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg08917208 chr2:24149416 ATAD2B 0.93 13.89 0.48 1.54e-38 Lymphocyte counts; BRCA cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA trans rs12517041 1.000 rs10079487 chr5:23294939 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg23711669 chr6:146136114 FBXO30 -0.76 -17.44 -0.57 5.18e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443189 0.570 rs6903448 chr6:76173832 C/T cg01950844 chr6:76311363 SENP6 0.75 11.63 0.42 1.75e-28 Prostate cancer; BRCA trans rs11098499 0.863 rs3775854 chr4:120471971 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs495337 0.965 rs2056991 chr20:48561280 T/C cg17835207 chr20:48524531 SPATA2 -0.57 -12.93 -0.46 3.72e-34 Psoriasis; BRCA cis rs11112613 0.713 rs11112587 chr12:105941285 G/A cg03607813 chr12:105948248 NA 0.6 11.21 0.41 9.3e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs11229555 0.645 rs6591475 chr11:58193551 G/T cg15696309 chr11:58395628 NA 0.45 9.64 0.36 1.31e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs11098499 0.909 rs10026736 chr4:120384322 G/C cg25214090 chr10:38739885 LOC399744 0.56 12.25 0.44 3.95e-31 Corneal astigmatism; BRCA cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.89e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.807 rs34982663 chr10:852521 C/G cg10556349 chr10:835070 NA 0.74 9.72 0.36 6.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs12995491 0.843 rs1878809 chr2:88518315 C/T cg04511125 chr2:88470314 THNSL2 -0.45 -9.09 -0.34 1.2e-18 Response to metformin (IC50); BRCA cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg18876405 chr7:65276391 NA -0.55 -13.31 -0.47 7.27e-36 Aortic root size; BRCA cis rs599083 0.530 rs576118 chr11:68177708 C/T cg01657329 chr11:68192670 LRP5 0.38 8.57 0.32 7.61e-17 Bone mineral density (spine); BRCA cis rs11718455 0.960 rs6781618 chr3:44001933 C/T cg08738300 chr3:44038990 NA 0.44 8.6 0.32 6.11e-17 Coronary artery disease; BRCA cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg13660082 chr14:53194042 PSMC6 -0.58 -8.74 -0.33 2.05e-17 Alzheimer's disease (late onset); BRCA cis rs12579753 0.917 rs11610365 chr12:82218108 C/T cg07988820 chr12:82153109 PPFIA2 -0.51 -8.64 -0.32 4.61e-17 Resting heart rate; BRCA cis rs595982 0.559 rs73061632 chr19:49361663 G/A cg21252483 chr19:49399788 TULP2 -0.42 -9.44 -0.35 7.09e-20 Red cell distribution width; BRCA cis rs250677 0.687 rs250666 chr5:148454622 A/G cg23229984 chr5:148520753 ABLIM3 0.36 9.03 0.34 1.96e-18 Breast cancer; BRCA cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.98 0.37 6.93e-22 Bipolar disorder; BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg03709012 chr19:19516395 GATAD2A 0.81 19.12 0.6 8.79e-65 Tonsillectomy; BRCA cis rs8017423 0.967 rs11621045 chr14:90714003 C/T cg04374321 chr14:90722782 PSMC1 0.75 21.12 0.64 1.65e-75 Mortality in heart failure; BRCA cis rs4722166 0.532 rs1546763 chr7:22757843 G/A cg05472934 chr7:22766657 IL6 0.42 10.54 0.38 4.6e-24 Lung cancer; BRCA cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg22834771 chr12:69754056 YEATS4 -0.37 -9.06 -0.34 1.6e-18 Blood protein levels; BRCA cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg21361702 chr7:150065534 REPIN1 0.49 9.99 0.37 6.08e-22 Blood protein levels;Circulating chemerin levels; BRCA cis rs112217694 1.000 rs17196218 chr4:104658371 C/T cg00875511 chr4:104641146 TACR3 -0.79 -8.51 -0.32 1.23e-16 Menarche (age at onset); BRCA cis rs796364 0.906 rs281766 chr2:200820505 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.81 13.5 0.47 9.75e-37 Schizophrenia; BRCA cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs7356093 chr3:134238753 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -20.03 -0.62 1.28e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7131987 0.903 rs7970390 chr12:29398655 A/G cg09582351 chr12:29534625 ERGIC2 -0.37 -8.89 -0.33 6.25e-18 QT interval; BRCA cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg16325326 chr1:53192061 ZYG11B 0.9 23.98 0.69 4.18e-91 Monocyte count; BRCA cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6940638 0.662 rs7759694 chr6:27240956 C/T cg12292205 chr6:26970375 C6orf41 -0.4 -8.08 -0.3 3.33e-15 Intelligence (multi-trait analysis); BRCA cis rs9473147 0.516 rs6903331 chr6:47562915 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.62 0.36 1.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg11764359 chr7:65958608 NA 0.78 18.6 0.59 4.85e-62 Aortic root size; BRCA cis rs4594175 0.926 rs12432356 chr14:51631223 T/G cg23942311 chr14:51606299 NA 0.33 8.3 0.31 6.24e-16 Cancer; BRCA cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg09184832 chr6:79620586 NA -0.48 -10.52 -0.38 5.72e-24 Intelligence (multi-trait analysis); BRCA cis rs10028773 0.515 rs9994651 chr4:120587803 C/T cg09307838 chr4:120376055 NA 0.51 10.45 0.38 1.03e-23 Educational attainment; BRCA cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg25237894 chr2:233734115 C2orf82 0.4 11.5 0.41 6.01e-28 Coronary artery disease; BRCA cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg25019033 chr10:957182 NA -0.41 -7.82 -0.3 2.14e-14 Eosinophil percentage of granulocytes; BRCA cis rs9810890 1.000 rs73196999 chr3:128460581 G/A cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs13223928 0.621 rs4722440 chr7:3155901 C/T cg19214707 chr7:3157722 NA 0.43 10.61 0.39 2.58e-24 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs7927771 0.864 rs2868459 chr11:47454972 C/G cg20307385 chr11:47447363 PSMC3 -0.43 -9.14 -0.34 8.32e-19 Subjective well-being; BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg08470875 chr2:26401718 FAM59B -0.63 -9.45 -0.35 6.52e-20 Gut microbiome composition (summer); BRCA cis rs7264396 0.635 rs7263302 chr20:34545858 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.8 -0.51 7.97e-43 Total cholesterol levels; BRCA cis rs11229555 0.574 rs12292024 chr11:58186716 C/T cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.23e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs908922 0.676 rs7532535 chr1:152517597 T/A cg20991723 chr1:152506922 NA 0.39 8.95 0.33 3.87e-18 Hair morphology; BRCA cis rs2760061 0.626 rs2527615 chr1:228119283 A/G cg02753203 chr1:228287806 NA -0.6 -13.01 -0.46 1.74e-34 Diastolic blood pressure; BRCA cis rs7666738 0.830 rs880472 chr4:98922595 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.37 0.38 2.18e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2762353 0.574 rs9467574 chr6:25705718 C/G cg12310025 chr6:25882481 NA 0.71 17.2 0.56 8.61e-55 Blood metabolite levels; BRCA cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.02 0.62 1.47e-69 Chronic sinus infection; BRCA cis rs10504229 0.817 rs114173899 chr8:58170640 G/T cg14926445 chr8:58193284 C8orf71 -0.44 -8.25 -0.31 8.87e-16 Developmental language disorder (linguistic errors); BRCA cis rs7312933 0.558 rs61926593 chr12:42818912 C/T cg01256987 chr12:42539512 GXYLT1 -0.42 -8.08 -0.3 3.18e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg23978390 chr7:1156363 C7orf50 0.41 10.01 0.37 5.05e-22 Longevity;Endometriosis; BRCA cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg00074818 chr8:8560427 CLDN23 0.38 8.27 0.31 7.99e-16 Obesity-related traits; BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg04166393 chr7:2884313 GNA12 0.48 9.2 0.34 5.15e-19 Height; BRCA cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.47 10.81 0.39 4.08e-25 Personality dimensions; BRCA cis rs34330 0.562 rs11055025 chr12:12866619 A/T cg04607235 chr12:12878440 APOLD1 -0.56 -9.06 -0.34 1.55e-18 Systemic lupus erythematosus; BRCA cis rs875971 0.545 rs67397473 chr7:65633305 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.13 0.37 1.76e-22 Aortic root size; BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg02951883 chr7:2050386 MAD1L1 -0.58 -15.16 -0.51 1.47e-44 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.863 rs3775847 chr4:120447642 A/C cg09307838 chr4:120376055 NA 0.69 13.97 0.48 6.93e-39 Corneal astigmatism; BRCA cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.71 -0.36 6.91e-21 Tonsillectomy; BRCA cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.59e-24 Motion sickness; BRCA trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg00717180 chr2:96193071 NA -0.38 -10.34 -0.38 2.9e-23 HDL cholesterol; BRCA cis rs546131 0.963 rs539044 chr11:34841542 G/T cg06937548 chr11:34938143 PDHX;APIP 0.45 8.56 0.32 8.61e-17 Lung disease severity in cystic fibrosis; BRCA trans rs7980799 0.682 rs1447873 chr12:33615236 A/G cg26384229 chr12:38710491 ALG10B -0.49 -10.61 -0.39 2.49e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg15017067 chr4:17643749 FAM184B 0.26 7.88 0.3 1.46e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg05347473 chr6:146136440 FBXO30 -0.41 -7.97 -0.3 7.08e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg13256891 chr4:100009986 ADH5 -0.5 -9.49 -0.35 4.68e-20 Alcohol dependence; BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.68 0.42 1.07e-28 Tonsillectomy; BRCA cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg26769984 chr7:1090371 C7orf50 0.49 8.99 0.34 2.82e-18 Bronchopulmonary dysplasia; BRCA cis rs13223928 0.605 rs10951052 chr7:3155301 A/G cg19214707 chr7:3157722 NA -0.37 -8.08 -0.3 3.36e-15 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs7766436 0.614 rs11753682 chr6:22566908 C/T cg13666174 chr6:22585274 NA -0.41 -8.66 -0.32 3.86e-17 Coronary artery disease; BRCA trans rs12517041 1.000 rs10941982 chr5:23298902 A/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs897984 0.574 rs11647284 chr16:31077335 G/A cg00531865 chr16:30841666 NA -0.38 -8.79 -0.33 1.42e-17 Dementia with Lewy bodies; BRCA cis rs2404602 0.647 rs10851889 chr15:77023336 C/T cg23625390 chr15:77176239 SCAPER -0.56 -14.11 -0.49 1.55e-39 Blood metabolite levels; BRCA cis rs3857067 0.806 rs2171379 chr4:95100243 A/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -8.99 -0.33 2.87e-18 QT interval; BRCA cis rs7666738 0.819 rs13139560 chr4:99081188 C/T cg05340658 chr4:99064831 C4orf37 0.51 9.66 0.36 1.03e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.617 rs166106 chr5:148447061 T/C cg25326776 chr5:148520934 ABLIM3 -0.44 -8.07 -0.3 3.41e-15 Breast cancer; BRCA cis rs9649465 0.561 rs631445 chr7:123413707 C/T cg03229431 chr7:123269106 ASB15 -0.44 -9.99 -0.37 6.24e-22 Migraine; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26119090 chr2:26468346 HADHA;HADHB 1.05 21.83 0.65 2.38e-79 Gut microbiome composition (summer); BRCA cis rs10193935 1.000 rs58962161 chr2:42400278 T/A cg27598129 chr2:42591480 NA -0.59 -9.82 -0.36 2.69e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg00149659 chr3:10157352 C3orf10 0.77 13.27 0.46 1.17e-35 Alzheimer's disease; BRCA cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.19 0.4 1.19e-26 Homoarginine levels; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg19748678 chr4:122722346 EXOSC9 0.74 16.41 0.54 9.23e-51 Type 2 diabetes; BRCA cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 4.09e-29 Bipolar disorder; BRCA cis rs250677 1.000 rs190378 chr5:148434275 G/T cg12140854 chr5:148520817 ABLIM3 -0.4 -8.45 -0.32 2.04e-16 Breast cancer; BRCA cis rs3820928 0.874 rs10169717 chr2:227796911 T/G cg11843606 chr2:227700838 RHBDD1 -0.4 -8.84 -0.33 9.34e-18 Pulmonary function; BRCA cis rs1707322 0.963 rs4553121 chr1:46375253 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg08888203 chr3:10149979 C3orf24 0.58 11.86 0.42 1.8e-29 Alzheimer's disease; BRCA cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.8e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs6952808 0.609 rs12699453 chr7:1953056 C/T cg04565464 chr8:145669602 NFKBIL2 0.35 8.72 0.33 2.47e-17 Bipolar disorder and schizophrenia; BRCA cis rs17228212 1.000 rs10152987 chr15:67451721 G/A cg26876701 chr15:67458665 SMAD3 -0.44 -8.41 -0.32 2.66e-16 Coronary heart disease; BRCA cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs311392 0.902 rs681000 chr8:55094043 C/T cg11783602 chr8:55087084 NA -0.32 -9.36 -0.35 1.36e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.15e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6866344 0.570 rs1132338 chr5:178139442 T/G cg10224037 chr5:178157518 ZNF354A 0.77 17.65 0.57 4.35e-57 Neutrophil percentage of white cells; BRCA cis rs17023223 0.537 rs11487668 chr1:119726796 T/C cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg11663144 chr21:46675770 NA -0.55 -12.77 -0.45 2.06e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs36096196 0.891 rs12082516 chr1:2251160 C/T cg18313694 chr15:45480185 SHF -0.43 -8.44 -0.32 2.17e-16 Coronary artery disease; BRCA cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.53 11.59 0.42 2.61e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs908922 0.676 rs12129646 chr1:152518816 C/T cg20991723 chr1:152506922 NA 0.38 8.61 0.32 5.89e-17 Hair morphology; BRCA cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.55 11.44 0.41 1.07e-27 Multiple sclerosis; BRCA cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg16049864 chr8:95962084 TP53INP1 -0.49 -12.19 -0.43 6.83e-31 Type 2 diabetes; BRCA cis rs4319547 0.656 rs10744209 chr12:122931568 G/A cg05707623 chr12:122985044 ZCCHC8 -0.51 -9.89 -0.36 1.52e-21 Body mass index; BRCA cis rs2762353 0.603 rs12201071 chr6:25778055 C/T cg03264133 chr6:25882463 NA 0.38 8.19 0.31 1.45e-15 Blood metabolite levels; BRCA cis rs6546550 0.935 rs2168115 chr2:70034793 A/G cg02498382 chr2:70120550 SNRNP27 -0.48 -10.0 -0.37 5.72e-22 Prevalent atrial fibrillation; BRCA trans rs11098499 0.909 rs7681214 chr4:120385320 C/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg06115741 chr20:33292138 TP53INP2 -0.4 -8.78 -0.33 1.47e-17 Glomerular filtration rate (creatinine); BRCA cis rs1215050 0.740 rs2695464 chr4:98980929 T/C cg05340658 chr4:99064831 C4orf37 -0.46 -10.55 -0.39 4.27e-24 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs911555 0.755 rs34411783 chr14:103900639 G/A cg17675199 chr6:35436792 RPL10A -0.31 -8.3 -0.31 6.43e-16 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg01877450 chr7:97915802 BRI3 -0.38 -8.45 -0.32 2.03e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs9304742 0.962 rs12459008 chr19:53454789 A/T cg24044776 chr19:53454761 ZNF816A 0.42 9.51 0.35 3.89e-20 Psoriasis; BRCA cis rs9902453 0.791 rs3115086 chr17:28025949 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 14.3 0.49 1.88e-40 Coffee consumption (cups per day); BRCA cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs4285028 0.948 rs12493952 chr3:121708497 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.85 -0.39 2.82e-25 Multiple sclerosis; BRCA cis rs7843479 0.965 rs17616085 chr8:21857267 C/T cg17168535 chr8:21777572 XPO7 0.42 9.23 0.34 4.02e-19 Mean corpuscular volume; BRCA cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg20203395 chr5:56204925 C5orf35 -0.42 -9.42 -0.35 8.19e-20 Initial pursuit acceleration; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg23285459 chr7:2802560 GNA12 -0.29 -7.81 -0.3 2.44e-14 Height; BRCA cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg18404041 chr3:52824283 ITIH1 -0.48 -15.12 -0.51 2.21e-44 Bipolar disorder; BRCA cis rs1059312 1.000 rs7136092 chr12:129280164 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.84 -0.53 6.63e-48 Systemic lupus erythematosus; BRCA cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg20818283 chr2:191399100 TMEM194B 0.38 8.94 0.33 4.06e-18 Pulse pressure; BRCA cis rs765787 0.530 rs1706832 chr15:45517173 C/T cg15395560 chr15:45543142 SLC28A2 0.3 8.32 0.31 5.4e-16 Uric acid levels; BRCA trans rs9409565 0.826 rs4744345 chr9:97207669 G/A cg05679027 chr9:99775184 HIATL2 -0.43 -9.44 -0.35 6.67e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs7560272 0.501 rs2421675 chr2:73955301 C/A cg20560298 chr2:73613845 ALMS1 0.33 8.5 0.32 1.3e-16 Schizophrenia; BRCA cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg17971929 chr21:40555470 PSMG1 -0.61 -13.46 -0.47 1.59e-36 Cognitive function; BRCA cis rs977987 0.735 rs166013 chr16:75434146 C/T cg07303275 chr16:75499416 TMEM170A -0.36 -7.98 -0.3 6.95e-15 Dupuytren's disease; BRCA trans rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05039488 chr6:79577232 IRAK1BP1 0.36 8.06 0.3 3.87e-15 Endometrial cancer; BRCA cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA trans rs453301 0.571 rs330048 chr8:9087278 A/C cg06636001 chr8:8085503 FLJ10661 -0.57 -13.05 -0.46 1.11e-34 Joint mobility (Beighton score); BRCA cis rs4727027 0.704 rs13221837 chr7:148903597 C/T cg23583168 chr7:148888333 NA -0.96 -25.88 -0.72 1.37e-101 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6088813 1.000 rs6142373 chr20:33983314 T/A cg14752227 chr20:34000481 UQCC -0.39 -8.33 -0.31 4.79e-16 Height; BRCA cis rs3771570 1.000 rs73002147 chr2:242302934 T/C cg21155796 chr2:242212141 HDLBP 0.6 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs795544 0.507 rs1995389 chr5:13785118 G/A cg07548982 chr5:13769939 DNAH5 -0.38 -7.94 -0.3 9.17e-15 Corneal astigmatism; BRCA trans rs9951602 0.512 rs4799249 chr18:76654370 A/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.3 0.59 1.73e-60 Obesity-related traits; BRCA cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg18016565 chr1:150552671 MCL1 0.37 8.68 0.32 3.35e-17 Tonsillectomy; BRCA cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg12444411 chr7:2802554 GNA12 -0.33 -8.27 -0.31 7.86e-16 Height; BRCA cis rs490234 0.966 rs545900 chr9:128341278 C/T cg14078157 chr9:128172775 NA 0.37 9.11 0.34 1.01e-18 Mean arterial pressure; BRCA cis rs2243480 1.000 rs13237037 chr7:65997882 T/C cg18252515 chr7:66147081 NA -1.06 -15.85 -0.53 6.1e-48 Diabetic kidney disease; BRCA cis rs1003719 0.713 rs7277150 chr21:38490006 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.14 0.49 1.04e-39 Eye color traits; BRCA cis rs977987 0.778 rs4888413 chr16:75443223 C/A cg03315344 chr16:75512273 CHST6 0.53 12.52 0.44 2.66e-32 Dupuytren's disease; BRCA cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.38 0.49 7.85e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs877529 0.932 rs139403 chr22:39547021 G/A cg18708252 chr22:39545030 CBX7 -0.31 -8.17 -0.31 1.66e-15 Multiple myeloma; BRCA cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg21951975 chr1:209979733 IRF6 0.38 9.14 0.34 8.28e-19 Cleft lip with or without cleft palate; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg23285459 chr7:2802560 GNA12 -0.34 -8.64 -0.32 4.6e-17 Height; BRCA trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1372520 0.684 rs2619355 chr4:90748374 A/C cg15133208 chr4:90757351 SNCA -0.38 -7.85 -0.3 1.73e-14 Neuroticism; BRCA cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7833986 0.501 rs72653959 chr8:56996516 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.99 0.46 2.13e-34 Height; BRCA cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.55 -0.44 1.8e-32 Personality dimensions; BRCA trans rs911555 0.755 rs4143998 chr14:103955247 T/C cg17675199 chr6:35436792 RPL10A 0.3 7.89 0.3 1.31e-14 Intelligence (multi-trait analysis); BRCA cis rs2996428 0.667 rs7538067 chr1:3761772 C/T cg17848003 chr1:3704513 LRRC47 0.25 7.81 0.3 2.3e-14 Red cell distribution width; BRCA cis rs12579753 0.871 rs12822050 chr12:82183041 C/T cg07988820 chr12:82153109 PPFIA2 -0.48 -8.46 -0.32 1.8e-16 Resting heart rate; BRCA cis rs2637266 0.935 rs1866891 chr10:78396941 C/A cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg18876405 chr7:65276391 NA -0.57 -13.62 -0.47 3e-37 Aortic root size; BRCA cis rs4332037 0.539 rs4470910 chr7:2071723 C/T cg02743256 chr7:2109353 MAD1L1 -0.45 -8.4 -0.32 2.95e-16 Bipolar disorder; BRCA cis rs2806561 0.765 rs2806556 chr1:23502850 G/A cg12483005 chr1:23474871 LUZP1 0.47 10.25 0.38 6.45e-23 Height; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg22903471 chr2:27725779 GCKR -0.38 -9.45 -0.35 6.07e-20 Total body bone mineral density; BRCA cis rs877282 0.898 rs11253339 chr10:759640 C/T cg17470449 chr10:769945 NA 0.48 8.19 0.31 1.45e-15 Uric acid levels; BRCA cis rs9291683 0.588 rs3756237 chr4:10013378 G/A cg11266682 chr4:10021025 SLC2A9 0.5 13.18 0.46 3.04e-35 Bone mineral density; BRCA cis rs7772486 0.748 rs2748484 chr6:146333653 C/T cg23711669 chr6:146136114 FBXO30 0.65 14.82 0.51 6.27e-43 Lobe attachment (rater-scored or self-reported); BRCA trans rs877282 1.000 rs34257857 chr10:772993 C/A cg22713356 chr15:30763199 NA 1.19 24.18 0.69 3.39e-92 Uric acid levels; BRCA cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.55 -9.61 -0.36 1.58e-20 Schizophrenia; BRCA cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg15395560 chr15:45543142 SLC28A2 0.29 8.08 0.3 3.22e-15 Uric acid levels; BRCA cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg05347473 chr6:146136440 FBXO30 0.54 10.31 0.38 3.7e-23 Lobe attachment (rater-scored or self-reported); BRCA trans rs6582630 0.555 rs56228141 chr12:38518652 T/G cg06521331 chr12:34319734 NA -0.47 -8.74 -0.33 2e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs10193935 0.901 rs55978605 chr2:42573402 C/A cg27598129 chr2:42591480 NA -0.86 -14.02 -0.49 3.8e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs6121246 0.909 rs6119720 chr20:30347568 T/G cg13852791 chr20:30311386 BCL2L1 0.84 16.58 0.55 1.35e-51 Mean corpuscular hemoglobin; BRCA cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg02475777 chr4:1388615 CRIPAK 0.69 13.02 0.46 1.51e-34 Longevity; BRCA trans rs75804782 0.630 rs3739070 chr2:239306268 A/C cg01134436 chr17:81009848 B3GNTL1 0.76 8.18 0.31 1.48e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs6484504 0.576 rs2756191 chr11:31135882 A/T cg14844989 chr11:31128820 NA 0.42 9.16 0.34 6.83e-19 Red blood cell count; BRCA cis rs11252926 0.545 rs10466270 chr10:556129 A/G cg03684893 chr10:554711 DIP2C -0.4 -10.02 -0.37 4.73e-22 Psychosis in Alzheimer's disease; BRCA trans rs208520 0.690 rs851458 chr6:66813279 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.04 -0.64 4.74e-75 Exhaled nitric oxide output; BRCA cis rs2882667 0.690 rs825761 chr5:138138007 A/G cg04439458 chr5:138467593 SIL1 0.31 7.89 0.3 1.27e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs367615 0.918 rs72797472 chr5:108881343 C/T cg17395555 chr5:108820864 NA 0.38 9.57 0.35 2.31e-20 Colorectal cancer (SNP x SNP interaction); BRCA cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg26149184 chr10:133730230 NA 0.41 8.15 0.31 1.9e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9443645 0.810 rs7753531 chr6:79789996 A/C cg11833968 chr6:79620685 NA -0.41 -9.02 -0.34 2.16e-18 Intelligence (multi-trait analysis); BRCA cis rs12618769 0.652 rs6736755 chr2:99204428 A/G cg10123293 chr2:99228465 UNC50 -0.41 -8.53 -0.32 1.06e-16 Bipolar disorder; BRCA cis rs4648739 0.613 rs13303201 chr1:1903712 G/T cg03688085 chr1:1910585 KIAA1751 -0.54 -11.42 -0.41 1.29e-27 Severe influenza A (H1N1) infection; BRCA trans rs17685 0.672 rs1639623 chr7:75707951 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 28.37 0.75 3.22e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg21248554 chr2:27665150 KRTCAP3 -0.36 -9.26 -0.34 2.94e-19 Total body bone mineral density; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26314531 chr2:26401878 FAM59B -0.84 -15.68 -0.53 3.92e-47 Gut microbiome composition (summer); BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg05457628 chr5:178986728 RUFY1 0.45 9.75 0.36 4.96e-21 Lung cancer; BRCA cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg13319975 chr6:146136371 FBXO30 0.41 9.3 0.35 2.13e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg18301423 chr5:131593218 PDLIM4 0.35 8.75 0.33 1.93e-17 Acylcarnitine levels; BRCA cis rs17401966 0.931 rs11584023 chr1:10302596 A/G cg03954927 chr1:10346856 KIF1B 0.47 14.99 0.51 1e-43 Hepatocellular carcinoma; BRCA cis rs3892630 0.878 rs66788054 chr19:33190146 G/T cg22980127 chr19:33182716 NUDT19 0.9 18.06 0.58 3.08e-59 Red blood cell traits; BRCA cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg23205692 chr1:25664452 TMEM50A 0.42 10.0 0.37 5.9e-22 Plateletcrit;Mean corpuscular volume; BRCA cis rs7246657 0.551 rs10419174 chr19:37605341 A/G cg23950597 chr19:37808831 NA -0.64 -9.53 -0.35 3.31e-20 Coronary artery calcification; BRCA cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg12658694 chr1:38397304 INPP5B 0.4 8.46 0.32 1.83e-16 Coronary artery disease; BRCA cis rs1829883 0.898 rs1464639 chr5:98786821 A/G cg08333243 chr5:99726346 NA -0.35 -7.97 -0.3 7.41e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs17270561 0.609 rs1892246 chr6:25764408 C/T cg16482183 chr6:26056742 HIST1H1C 0.47 9.31 0.35 2.05e-19 Iron status biomarkers; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg08805041 chr16:621841 PIGQ -0.32 -8.87 -0.33 7.31e-18 Height; BRCA cis rs6570726 0.935 rs385134 chr6:145851005 C/T cg23711669 chr6:146136114 FBXO30 0.65 15.3 0.52 2.9e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg26587870 chr6:27730563 NA -0.42 -9.05 -0.34 1.75e-18 Parkinson's disease; BRCA cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.22 -0.44 5.29e-31 Chronic sinus infection; BRCA cis rs875971 0.660 rs801193 chr7:66030612 A/C cg18876405 chr7:65276391 NA -0.61 -14.9 -0.51 2.7e-43 Aortic root size; BRCA cis rs847649 0.842 rs869332 chr7:102632247 A/G cg18108683 chr7:102477205 FBXL13 -0.4 -9.49 -0.35 4.61e-20 Morning vs. evening chronotype; BRCA cis rs1801251 0.778 rs812383 chr2:233737132 C/A cg08000102 chr2:233561755 GIGYF2 -0.47 -10.35 -0.38 2.51e-23 Coronary artery disease; BRCA cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg16339924 chr4:17578868 LAP3 0.71 16.87 0.56 4.12e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7851660 0.935 rs12347191 chr9:100619719 C/T cg13688889 chr9:100608707 NA -0.36 -8.74 -0.33 2.08e-17 Strep throat; BRCA cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg12365402 chr11:9010492 NRIP3 0.38 8.28 0.31 7.25e-16 Hemoglobin concentration; BRCA cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.63e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg13010199 chr12:38710504 ALG10B 0.5 10.42 0.38 1.39e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs4363385 0.747 rs4319267 chr1:152972699 T/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.22 -0.31 1.13e-15 Inflammatory skin disease; BRCA cis rs8044868 0.530 rs2287998 chr16:72059269 C/T cg16558253 chr16:72132732 DHX38 0.37 9.1 0.34 1.1e-18 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA trans rs10411161 0.690 rs7252336 chr19:52389514 C/T cg22319618 chr22:45562946 NUP50 -0.42 -8.02 -0.3 4.89e-15 Breast cancer; BRCA cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg08975724 chr8:8085496 FLJ10661 0.5 11.13 0.4 1.93e-26 Mood instability; BRCA cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 22.21 0.66 2e-81 Platelet count; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg14004847 chr7:1930337 MAD1L1 -0.44 -8.95 -0.33 3.78e-18 Bipolar disorder and schizophrenia; BRCA cis rs7927771 0.832 rs4992357 chr11:47393638 C/T cg20307385 chr11:47447363 PSMC3 -0.38 -8.04 -0.3 4.24e-15 Subjective well-being; BRCA cis rs8062405 1.000 rs4451951 chr16:28836205 T/C cg09754948 chr16:28834200 ATXN2L 0.47 9.44 0.35 6.65e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9790314 0.846 rs4290817 chr3:160967354 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA cis rs589448 0.902 rs315138 chr12:69764850 A/T cg22834771 chr12:69754056 YEATS4 -0.42 -10.58 -0.39 3.25e-24 Cerebrospinal fluid biomarker levels; BRCA trans rs629535 0.814 rs488231 chr8:70064993 T/C cg21567404 chr3:27674614 NA 1.01 20.79 0.64 9.62e-74 Dupuytren's disease; BRCA cis rs7089973 0.584 rs758585 chr10:116582560 C/A cg23260525 chr10:116636907 FAM160B1 0.3 7.91 0.3 1.12e-14 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg06046430 chr4:77819534 ANKRD56 0.62 14.01 0.48 4.21e-39 Emphysema distribution in smoking; BRCA cis rs17023223 0.509 rs56195272 chr1:119713997 A/T cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs7474896 0.537 rs1022449 chr10:38279467 T/A cg25427524 chr10:38739819 LOC399744 0.54 9.63 0.36 1.4e-20 Obesity (extreme); BRCA cis rs7904368 0.806 rs7899923 chr10:16857394 G/A cg14835575 chr10:16859367 RSU1 0.61 12.44 0.44 5.82e-32 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7927771 0.542 rs7122217 chr11:47777920 G/C cg20307385 chr11:47447363 PSMC3 -0.41 -9.68 -0.36 9.19e-21 Subjective well-being; BRCA cis rs881375 0.967 rs7034653 chr9:123687372 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.9 0.4 1.8e-25 Rheumatoid arthritis; BRCA cis rs1577917 0.958 rs12213343 chr6:86443019 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.19 -0.31 1.37e-15 Response to antipsychotic treatment; BRCA cis rs28595532 0.920 rs114080496 chr4:119726372 C/T cg11846333 chr4:119757529 SEC24D 0.61 7.97 0.3 7.34e-15 Cannabis dependence symptom count; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.12 0.64 1.61e-75 Gut microbiome composition (summer); BRCA cis rs2346177 0.576 rs1530621 chr2:46688688 T/C cg02822958 chr2:46747628 ATP6V1E2 0.55 10.5 0.38 6.63e-24 HDL cholesterol; BRCA trans rs62103177 0.733 rs62096747 chr18:77619568 A/G cg05926928 chr17:57297772 GDPD1 1.2 16.06 0.54 5.5e-49 Opioid sensitivity; BRCA cis rs7762018 1.000 rs6904601 chr6:170131905 T/G cg19338460 chr6:170058176 WDR27 -0.44 -7.89 -0.3 1.28e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs10851411 0.559 rs17767270 chr15:42898612 A/G cg21293051 chr15:42870591 STARD9 -0.46 -7.94 -0.3 8.97e-15 Glucose homeostasis traits; BRCA cis rs9658691 0.607 rs3740281 chr10:90772150 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.55 -8.04 -0.3 4.34e-15 Mosquito bite size; BRCA cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg10523679 chr1:76189770 ACADM 0.76 15.96 0.53 1.58e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17376456 0.825 rs10476590 chr5:93244884 A/T cg21475434 chr5:93447410 FAM172A 0.67 8.51 0.32 1.24e-16 Diabetic retinopathy; BRCA trans rs6952808 0.575 rs2056479 chr7:1954273 G/A cg04565464 chr8:145669602 NFKBIL2 0.35 8.71 0.33 2.55e-17 Bipolar disorder and schizophrenia; BRCA cis rs2012796 1.000 rs8009171 chr14:81820060 G/A cg02996355 chr14:81879375 NA 0.49 9.72 0.36 6.62e-21 Night sleep phenotypes; BRCA cis rs11711311 1.000 rs2566968 chr3:113474154 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.66 0.32 3.97e-17 IgG glycosylation; BRCA cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.41e-20 Menopause (age at onset); BRCA cis rs11098499 0.909 rs10026736 chr4:120384322 G/C cg09307838 chr4:120376055 NA 0.71 14.51 0.5 1.94e-41 Corneal astigmatism; BRCA cis rs4648845 0.579 rs4592207 chr1:2369498 A/G cg07700843 chr1:2391317 NA -0.38 -8.87 -0.33 7.4e-18 Schizophrenia; BRCA cis rs2243480 1.000 rs34529418 chr7:65403209 A/G cg18252515 chr7:66147081 NA -0.82 -11.87 -0.43 1.67e-29 Diabetic kidney disease; BRCA cis rs11190604 1.000 rs74210981 chr10:102287520 C/T cg07080220 chr10:102295463 HIF1AN 0.62 13.19 0.46 2.51e-35 Palmitoleic acid (16:1n-7) levels; BRCA trans rs208520 0.661 rs207079 chr6:66770462 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.29 -0.64 2.05e-76 Exhaled nitric oxide output; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg16590910 chr6:42928470 GNMT 0.42 9.3 0.35 2.26e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg08975724 chr8:8085496 FLJ10661 0.5 10.64 0.39 1.9e-24 Mood instability; BRCA trans rs7824557 0.933 rs6601576 chr8:11100275 A/T cg06636001 chr8:8085503 FLJ10661 -0.47 -9.08 -0.34 1.37e-18 Retinal vascular caliber; BRCA cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg21138405 chr5:131827807 IRF1 0.4 13.0 0.46 1.85e-34 Asthma (sex interaction); BRCA cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs7267979 0.966 rs2424715 chr20:25420077 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00149659 chr3:10157352 C3orf10 0.74 12.95 0.46 3.21e-34 Alzheimer's disease; BRCA cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.34 8.08 0.3 3.21e-15 Tonsillectomy; BRCA cis rs13102973 0.931 rs4608864 chr4:135883488 G/A cg14419869 chr4:135874104 NA 0.55 11.41 0.41 1.41e-27 Subjective well-being; BRCA trans rs11039798 0.764 rs10838882 chr11:48393035 T/A cg15704280 chr7:45808275 SEPT13 0.55 8.22 0.31 1.18e-15 Axial length; BRCA cis rs875971 0.830 rs778711 chr7:65851657 G/A cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.8 -0.62 2.12e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs910316 0.737 rs175065 chr14:75494983 T/C cg23033748 chr14:75592666 NEK9 -0.35 -8.17 -0.31 1.7e-15 Height; BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg14789911 chr21:47582049 C21orf56 0.38 8.14 0.31 2.04e-15 Testicular germ cell tumor; BRCA cis rs1707322 1.000 rs1707303 chr1:46598273 A/C cg03146154 chr1:46216737 IPP -0.42 -8.82 -0.33 1.08e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1005277 0.579 rs2474563 chr10:38375938 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 3.98e-39 Extrinsic epigenetic age acceleration; BRCA cis rs7246657 0.722 rs1564208 chr19:38041221 A/G cg23950597 chr19:37808831 NA -0.51 -8.79 -0.33 1.43e-17 Coronary artery calcification; BRCA cis rs459571 0.959 rs416390 chr9:136908549 C/G cg13789015 chr9:136890014 NCRNA00094 -0.73 -15.22 -0.52 7.46e-45 Platelet distribution width; BRCA cis rs9902453 0.791 rs3115090 chr17:28035014 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 14.47 0.5 2.96e-41 Coffee consumption (cups per day); BRCA cis rs965469 1.000 rs3310 chr20:3237232 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.45 -0.38 1.02e-23 IFN-related cytopenia; BRCA cis rs2637266 0.967 rs2579748 chr10:78328313 T/C cg18941641 chr10:78392320 NA 0.35 7.99 0.3 6.18e-15 Pulmonary function; BRCA trans rs3857536 0.740 rs7763555 chr6:66889930 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.48 -9.67 -0.36 1.01e-20 Blood trace element (Cu levels); BRCA cis rs897984 0.683 rs729482 chr16:31016970 T/C cg00531865 chr16:30841666 NA -0.35 -8.01 -0.3 5.56e-15 Dementia with Lewy bodies; BRCA cis rs6964587 0.900 rs62467794 chr7:91850578 C/T cg17063962 chr7:91808500 NA 0.59 12.44 0.44 5.65e-32 Breast cancer; BRCA cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg12310025 chr6:25882481 NA 0.71 17.25 0.56 4.82e-55 Blood metabolite levels; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg12648201 chr2:27665141 KRTCAP3 0.36 8.82 0.33 1.1e-17 Total body bone mineral density; BRCA cis rs586533 0.881 rs623710 chr11:99505577 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs11971779 0.648 rs28754644 chr7:139065057 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.21 0.37 9.03e-23 Diisocyanate-induced asthma; BRCA cis rs9399135 0.933 rs4559100 chr6:135324085 T/C cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 8.89e-33 Red blood cell count; BRCA cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 19.95 0.62 3.19e-69 Smoking behavior; BRCA cis rs4713118 0.621 rs4713134 chr6:28034121 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.1 0.31 2.83e-15 Parkinson's disease; BRCA cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.03 -0.34 1.97e-18 Developmental language disorder (linguistic errors); BRCA cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.13 0.31 2.29e-15 Breast cancer; BRCA cis rs3857067 0.806 rs7654919 chr4:95136164 C/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.58 -0.35 2.04e-20 QT interval; BRCA cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg10802521 chr3:52805072 NEK4 -0.33 -8.8 -0.33 1.3e-17 Bipolar disorder; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg04234412 chr22:24373322 LOC391322 -0.57 -13.56 -0.47 5.19e-37 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg26408565 chr15:76604113 ETFA -0.53 -12.22 -0.44 5.34e-31 Blood metabolite levels; BRCA cis rs2235642 0.750 rs2859310 chr16:1656765 C/T cg26528668 chr16:1614120 IFT140 -0.36 -8.01 -0.3 5.64e-15 Coronary artery disease; BRCA cis rs875971 0.862 rs949930 chr7:65766822 C/G cg11764359 chr7:65958608 NA -0.77 -17.78 -0.58 9.24e-58 Aortic root size; BRCA cis rs798766 1.000 rs3752749 chr4:1737262 T/C cg10756475 chr4:1757242 NA 0.37 8.47 0.32 1.64e-16 Bladder cancer;Urinary bladder cancer; BRCA trans rs61931739 0.534 rs12371021 chr12:34062252 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.41 0.35 8.94e-20 Morning vs. evening chronotype; BRCA cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg12373951 chr3:133503437 NA 0.53 12.86 0.45 8.33e-34 Iron status biomarkers; BRCA cis rs10751667 0.666 rs7123912 chr11:963936 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.22 -0.54 7.89e-50 Alzheimer's disease (late onset); BRCA cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg25319279 chr11:5960081 NA -0.42 -8.43 -0.32 2.29e-16 DNA methylation (variation); BRCA cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs7617773 0.817 rs35414021 chr3:48293524 G/C cg11946769 chr3:48343235 NME6 0.67 13.85 0.48 2.39e-38 Coronary artery disease; BRCA cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.6 -10.22 -0.37 8.01e-23 Schizophrenia; BRCA cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg26587870 chr6:27730563 NA -0.4 -8.59 -0.32 6.5e-17 Parkinson's disease; BRCA cis rs7100689 0.784 rs7089058 chr10:82071263 T/C cg00277334 chr10:82204260 NA -0.43 -8.18 -0.31 1.58e-15 Post bronchodilator FEV1; BRCA cis rs4930561 0.739 rs10896303 chr11:67974292 C/A cg16338278 chr11:67432957 ALDH3B2 0.44 8.87 0.33 7.39e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs881375 0.933 rs7021206 chr9:123684157 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.42 -8.69 -0.33 2.96e-17 Rheumatoid arthritis; BRCA cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg21770322 chr7:97807741 LMTK2 0.43 11.54 0.42 4.06e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs11051970 0.679 rs2651377 chr12:32556919 A/C cg02745156 chr12:32552066 NA 0.25 8.49 0.32 1.48e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg20607798 chr8:58055168 NA 0.46 8.08 0.3 3.19e-15 Developmental language disorder (linguistic errors); BRCA cis rs5758511 0.634 rs1001587 chr22:42670111 C/T cg00645731 chr22:42541494 CYP2D7P1 0.57 11.09 0.4 2.88e-26 Birth weight; BRCA trans rs9858542 0.903 rs11917431 chr3:49644012 C/T cg21659725 chr3:3221576 CRBN -0.47 -9.71 -0.36 7.05e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg13319975 chr6:146136371 FBXO30 -0.44 -10.12 -0.37 2e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg10523679 chr1:76189770 ACADM 0.74 15.17 0.51 1.25e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg17063962 chr7:91808500 NA 0.55 12.95 0.46 3.28e-34 Breast cancer; BRCA cis rs9815354 0.812 rs4434125 chr3:42004681 A/G cg03022575 chr3:42003672 ULK4 0.74 10.27 0.38 5.43e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs6430585 0.528 rs660002 chr2:136723504 C/T cg07169764 chr2:136633963 MCM6 1.07 23.76 0.68 6.81e-90 Corneal structure; BRCA cis rs698833 0.547 rs1067355 chr2:44663152 C/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.47 -8.41 -0.32 2.6e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2404602 0.647 rs55778276 chr15:77136590 T/A cg23625390 chr15:77176239 SCAPER -0.55 -12.83 -0.45 1.08e-33 Blood metabolite levels; BRCA trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21582582 chr3:182698605 DCUN1D1 0.37 9.54 0.35 2.88e-20 Intelligence (multi-trait analysis); BRCA cis rs561341 1.000 rs555629 chr17:30294136 T/C cg23018236 chr17:30244563 NA -0.61 -10.02 -0.37 4.87e-22 Hip circumference adjusted for BMI; BRCA cis rs10089 1.000 rs13355233 chr5:127425350 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.68 -16.27 -0.54 4.94e-50 Ileal carcinoids; BRCA cis rs6878727 0.665 rs698181 chr5:123667269 T/C cg01806427 chr5:123737813 NA -0.37 -8.27 -0.31 7.92e-16 Breast cancer; BRCA cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg22535103 chr8:58192502 C8orf71 -0.61 -13.8 -0.48 4.41e-38 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.1 0.43 1.72e-30 Corneal astigmatism; BRCA cis rs9868809 0.772 rs9836462 chr3:48712791 C/T cg00383909 chr3:49044727 WDR6 -0.4 -7.83 -0.3 2.07e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs896854 0.738 rs527234 chr8:95963798 C/G cg13393036 chr8:95962371 TP53INP1 0.34 8.5 0.32 1.38e-16 Type 2 diabetes; BRCA cis rs9815354 0.812 rs73083333 chr3:41927505 G/A cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg04727924 chr7:799746 HEATR2 -0.54 -9.47 -0.35 5.45e-20 Cerebrospinal P-tau181p levels; BRCA cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs2731664 0.792 rs2545795 chr5:176887106 A/C cg23176889 chr5:176863531 GRK6 -0.62 -17.23 -0.56 6.44e-55 Intelligence (multi-trait analysis); BRCA cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg14019146 chr3:50243930 SLC38A3 -0.42 -10.19 -0.37 1.1e-22 Body mass index; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg05279229 chr7:1896384 MAD1L1 -0.43 -8.24 -0.31 9.88e-16 Bipolar disorder and schizophrenia; BRCA cis rs875971 1.000 rs2420591 chr7:65912381 T/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg01689657 chr7:91764605 CYP51A1 0.21 7.86 0.3 1.66e-14 Breast cancer; BRCA cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg25358565 chr5:93447407 FAM172A 1.23 18.97 0.6 5.63e-64 Diabetic retinopathy; BRCA cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg23262073 chr20:60523788 NA 0.4 8.5 0.32 1.35e-16 Body mass index; BRCA cis rs1941023 0.503 rs7944025 chr11:60142538 C/A cg08716584 chr11:60157161 MS4A7 -0.44 -10.27 -0.38 5.37e-23 Congenital heart disease (maternal effect); BRCA trans rs17685 0.712 rs7785025 chr7:75628101 C/T cg19862616 chr7:65841803 NCRNA00174 -0.81 -25.32 -0.71 1.65e-98 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs12479064 0.724 rs10496336 chr2:99996165 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.48 -9.32 -0.35 1.9e-19 Chronic sinus infection; BRCA cis rs12971120 0.891 rs4891557 chr18:72170299 C/T cg25817165 chr18:72167213 CNDP2 -0.76 -14.21 -0.49 4.8e-40 Refractive error; BRCA cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg05234568 chr11:5960015 NA -0.49 -9.72 -0.36 6.67e-21 DNA methylation (variation); BRCA cis rs752010 0.714 rs10789403 chr1:42085869 G/A cg06885757 chr1:42089581 HIVEP3 0.3 10.72 0.39 9.1e-25 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.37 0.57 1.22e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs68170813 0.559 rs12537785 chr7:107050221 T/C cg02696742 chr7:106810147 HBP1 -0.5 -8.02 -0.3 5.24e-15 Coronary artery disease; BRCA cis rs5771225 0.544 rs1555048 chr22:50688348 A/G cg16473166 chr22:50639996 SELO 0.5 8.98 0.33 2.97e-18 Late-onset Alzheimer's disease; BRCA cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.07 -0.3 3.48e-15 Prostate cancer; BRCA cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg03433033 chr1:76189801 ACADM 0.86 22.18 0.66 2.75e-81 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg16606324 chr3:10149918 C3orf24 0.58 10.28 0.38 4.75e-23 Alzheimer's disease; BRCA cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg00074818 chr8:8560427 CLDN23 0.38 8.37 0.31 3.69e-16 Obesity-related traits; BRCA cis rs9467711 0.591 rs13214280 chr6:26008620 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.21 0.34 4.54e-19 Autism spectrum disorder or schizophrenia; BRCA trans rs11098499 0.775 rs10021601 chr4:120282563 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs2797160 1.000 rs1777195 chr6:126006861 A/C cg05901451 chr6:126070800 HEY2 0.39 9.51 0.35 3.92e-20 Endometrial cancer; BRCA trans rs2204008 0.837 rs4432085 chr12:38181146 C/T cg06521331 chr12:34319734 NA -0.54 -9.72 -0.36 6.57e-21 Bladder cancer; BRCA cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs7258465 1.000 rs10164323 chr19:18569492 C/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.69 -0.33 2.96e-17 Breast cancer; BRCA trans rs11722228 0.522 rs7662229 chr4:10133014 A/T cg26043149 chr18:55253948 FECH 1.15 27.71 0.74 1.32e-111 Gout;Urate levels;Serum uric acid levels; BRCA cis rs6570726 0.791 rs9390336 chr6:145896823 A/T cg05347473 chr6:146136440 FBXO30 0.39 7.93 0.3 9.59e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.43e-20 Menopause (age at onset); BRCA cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg26597838 chr10:835615 NA -0.57 -10.48 -0.38 7.93e-24 Eosinophil percentage of granulocytes; BRCA cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.66 -0.32 3.87e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs11098499 0.863 rs11098531 chr4:120465001 G/A cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.85e-20 Tonsillectomy; BRCA cis rs1506636 1.000 rs1911145 chr7:123363658 A/G cg03229431 chr7:123269106 ASB15 -0.61 -13.77 -0.48 5.52e-38 Plateletcrit;Platelet count; BRCA cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg18876405 chr7:65276391 NA 0.62 15.35 0.52 1.76e-45 Aortic root size; BRCA cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg01579765 chr21:45077557 HSF2BP -0.39 -10.41 -0.38 1.48e-23 Mean corpuscular volume; BRCA cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.38 9.14 0.34 8.45e-19 Platelet count; BRCA cis rs1868673 1.000 rs1868673 chr3:150187314 A/C cg04908077 chr3:150187338 NA -0.34 -8.92 -0.33 4.69e-18 Waist circumference; BRCA cis rs7772486 0.790 rs6926076 chr6:146232804 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -8.06 -0.3 3.75e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467773 1.000 rs1884949 chr6:26568067 G/A cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.4e-57 Intelligence (multi-trait analysis); BRCA cis rs908922 0.676 rs4845789 chr1:152528100 A/G cg20991723 chr1:152506922 NA 0.37 8.29 0.31 6.78e-16 Hair morphology; BRCA cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg04013166 chr16:89971882 TCF25 0.52 9.51 0.35 3.81e-20 Skin colour saturation; BRCA cis rs4819052 0.679 rs8132135 chr21:46694782 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.47 10.31 0.38 3.68e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg26384229 chr12:38710491 ALG10B 0.59 13.47 0.47 1.41e-36 Morning vs. evening chronotype; BRCA cis rs853679 0.517 rs9357065 chr6:28129580 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg01689657 chr7:91764605 CYP51A1 0.23 8.3 0.31 6.06e-16 Breast cancer; BRCA cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg13770153 chr20:60521292 NA -0.39 -9.17 -0.34 6.38e-19 Body mass index; BRCA cis rs35110281 0.517 rs11089020 chr21:44939991 C/T cg04455712 chr21:45112962 RRP1B 0.4 10.54 0.38 4.55e-24 Mean corpuscular volume; BRCA cis rs7267979 1.000 rs2259928 chr20:25281834 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.1e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6430585 0.640 rs6716070 chr2:136544651 G/T cg07169764 chr2:136633963 MCM6 -1.16 -26.17 -0.72 3.58e-103 Corneal structure; BRCA cis rs921968 0.541 rs634590 chr2:219372768 C/A cg10223061 chr2:219282414 VIL1 -0.27 -7.83 -0.3 2.02e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs6450176 1.000 rs3776705 chr5:53304955 T/C ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.55 -0.52 1.79e-46 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21582582 chr3:182698605 DCUN1D1 -0.38 -9.98 -0.37 6.5600000000000005e-22 Intelligence (multi-trait analysis); BRCA cis rs1538970 1.000 rs4660853 chr1:45849090 C/T cg05343316 chr1:45956843 TESK2 0.56 11.54 0.42 4.02e-28 Platelet count; BRCA cis rs36051895 0.622 rs13440043 chr9:5268264 A/G cg02405213 chr9:5042618 JAK2 -0.45 -7.99 -0.3 6.1e-15 Pediatric autoimmune diseases; BRCA cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg03354898 chr7:1950403 MAD1L1 -0.39 -8.73 -0.33 2.21e-17 Schizophrenia; BRCA trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg25482853 chr8:67687455 SGK3 1.01 17.39 0.57 1.01e-55 Lung disease severity in cystic fibrosis; BRCA cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg11266682 chr4:10021025 SLC2A9 0.48 12.55 0.44 1.83e-32 Bone mineral density; BRCA cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.53 -11.27 -0.41 5.3e-27 IgG glycosylation; BRCA cis rs10193935 0.901 rs222488 chr2:42648570 T/G cg27598129 chr2:42591480 NA -0.8 -13.51 -0.47 8.88e-37 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg14004847 chr7:1930337 MAD1L1 -0.42 -8.75 -0.33 1.85e-17 Bipolar disorder and schizophrenia; BRCA cis rs68170813 0.559 rs12540475 chr7:106886295 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.47 -0.32 1.68e-16 Coronary artery disease; BRCA cis rs9814567 0.896 rs7642266 chr3:134346025 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.83 -0.58 5.39e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg08470875 chr2:26401718 FAM59B -0.72 -11.43 -0.41 1.17e-27 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA cis rs6089584 0.627 rs35560719 chr20:60561917 A/C cg06108461 chr20:60628389 TAF4 -0.64 -13.19 -0.46 2.75e-35 Body mass index; BRCA cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg12292205 chr6:26970375 C6orf41 0.64 14.48 0.5 2.69e-41 Autism spectrum disorder or schizophrenia; BRCA cis rs9868809 0.772 rs28452701 chr3:48708575 C/T cg00383909 chr3:49044727 WDR6 0.56 9.75 0.36 4.93e-21 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg21926612 chr6:163149169 PACRG;PARK2 1.05 16.09 0.54 3.73e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg11766577 chr21:47581405 C21orf56 -0.38 -8.22 -0.31 1.13e-15 Testicular germ cell tumor; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg13397359 chr6:42928475 GNMT 0.75 19.21 0.61 2.78e-65 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.59 -0.42 2.52e-28 Lymphocyte counts; BRCA cis rs11711311 1.000 rs9826465 chr3:113432254 G/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.53 0.32 1.05e-16 IgG glycosylation; BRCA cis rs735396 0.770 rs1169300 chr12:121431225 G/A cg02403541 chr12:121454288 C12orf43 0.64 12.16 0.43 9.39e-31 N-glycan levels; BRCA trans rs783540 0.867 rs7167880 chr15:83294436 G/A cg18393722 chr15:85113863 UBE2QP1 -0.29 -9.03 -0.34 1.97e-18 Schizophrenia; BRCA cis rs10864907 0.614 rs7557537 chr2:113702530 T/C cg12858261 chr2:113808755 IL1F8 0.35 7.86 0.3 1.59e-14 Pulmonary function; BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg03354898 chr7:1950403 MAD1L1 -0.46 -9.83 -0.36 2.58e-21 Schizophrenia; BRCA trans rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg17830980 chr10:43048298 ZNF37B -0.43 -9.94 -0.37 9.4e-22 Extrinsic epigenetic age acceleration; BRCA cis rs7246657 0.722 rs2909098 chr19:38204248 G/A cg23950597 chr19:37808831 NA 0.52 8.84 0.33 9.02e-18 Coronary artery calcification; BRCA trans rs1997103 0.906 rs4618644 chr7:55402037 T/G cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg08807101 chr21:30365312 RNF160 -0.59 -14.68 -0.5 3.1e-42 Dental caries; BRCA cis rs9467773 1.000 rs9467779 chr6:26536687 A/T cg09904177 chr6:26538194 HMGN4 -0.56 -18.15 -0.58 1.13e-59 Intelligence (multi-trait analysis); BRCA cis rs701145 0.537 rs1713815 chr3:153872445 T/C cg17054900 chr3:154042577 DHX36 0.41 8.21 0.31 1.19e-15 Coronary artery disease; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg10862848 chr6:42927986 GNMT -0.36 -14.95 -0.51 1.44e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg04455712 chr21:45112962 RRP1B 0.39 10.19 0.37 1.06e-22 Mean corpuscular volume; BRCA cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.4 0.32 3e-16 Breast cancer; BRCA cis rs1030877 0.557 rs2278501 chr2:105979506 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.46 -10.16 -0.37 1.38e-22 Obesity-related traits; BRCA cis rs11690935 0.595 rs788171 chr2:172921832 A/G cg13550731 chr2:172543902 DYNC1I2 0.55 14.0 0.48 4.94e-39 Schizophrenia; BRCA cis rs73001065 0.901 rs10401969 chr19:19407718 A/G cg03709012 chr19:19516395 GATAD2A 0.78 9.68 0.36 8.72e-21 LDL cholesterol; BRCA cis rs6964587 1.000 rs34043009 chr7:91578447 T/C cg17063962 chr7:91808500 NA -0.53 -12.53 -0.44 2.43e-32 Breast cancer; BRCA cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.34 -0.44 1.5e-31 Bipolar disorder; BRCA cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg13628971 chr7:2884303 GNA12 0.61 13.75 0.48 7.46e-38 Height; BRCA cis rs826838 1.000 rs826851 chr12:39112639 A/G cg26384229 chr12:38710491 ALG10B -0.62 -16.58 -0.55 1.23e-51 Heart rate; BRCA cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg00339695 chr16:24857497 SLC5A11 -0.5 -10.98 -0.4 8.17e-26 Intelligence (multi-trait analysis); BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg21280719 chr6:42927975 GNMT -0.31 -12.7 -0.45 4.13e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11583043 1.000 rs6700743 chr1:101447384 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.36 7.85 0.3 1.75e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs4660306 1.000 rs11211132 chr1:45990516 T/C cg24296786 chr1:45957014 TESK2 0.43 8.71 0.33 2.67e-17 Homocysteine levels; BRCA cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10465746 0.780 rs10874424 chr1:84424033 C/T cg10977910 chr1:84465055 TTLL7 0.58 11.99 0.43 5.17e-30 Obesity-related traits; BRCA cis rs11599315 0.507 rs12218307 chr10:1341914 G/A cg09624528 chr10:1369823 ADARB2 0.41 8.47 0.32 1.71e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs9818758 0.882 rs74926817 chr3:49378833 C/G cg00383909 chr3:49044727 WDR6 0.52 10.13 0.37 1.85e-22 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7582180 0.715 rs1866198 chr2:100917739 C/A cg14675211 chr2:100938903 LONRF2 0.46 10.44 0.38 1.12e-23 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.22 0.56 7.27e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs7633770 0.786 rs1520488 chr3:46677459 C/T cg11219411 chr3:46661640 NA 0.61 15.6 0.53 9.55e-47 Coronary artery disease; BRCA cis rs2882667 0.898 rs11952020 chr5:138395156 A/T cg04439458 chr5:138467593 SIL1 -0.33 -9.07 -0.34 1.44e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6460942 1.000 rs7792759 chr7:12311715 A/G cg06484146 chr7:12443880 VWDE 0.61 8.57 0.32 7.47e-17 Coronary artery disease; BRCA cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg09526685 chr4:187126073 CYP4V2 0.99 11.49 0.41 6.76e-28 Blood protein levels; BRCA cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg13902645 chr11:5959945 NA -0.46 -9.46 -0.35 5.87e-20 DNA methylation (variation); BRCA cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg26248373 chr2:1572462 NA -0.62 -14.4 -0.49 6.48e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.59 -11.24 -0.41 6.85e-27 Gut microbiome composition (summer); BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs208520 0.706 rs851601 chr6:66893853 G/A cg07460842 chr6:66804631 NA -0.93 -16.92 -0.56 2.38e-53 Exhaled nitric oxide output; BRCA cis rs11098499 0.908 rs9995234 chr4:120321827 A/G cg09307838 chr4:120376055 NA 0.7 13.97 0.48 7.08e-39 Corneal astigmatism; BRCA cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 9.09 0.34 1.19e-18 Personality dimensions; BRCA trans rs1459104 0.571 rs10459012 chr11:55091574 C/A cg15704280 chr7:45808275 SEPT13 0.55 9.87 0.36 1.74e-21 Body mass index; BRCA trans rs4596713 0.539 rs953812 chr9:71787631 T/C cg16512924 chr15:28394682 HERC2 0.45 10.56 0.39 3.97e-24 Headache; BRCA cis rs7927592 0.913 rs67005337 chr11:68307758 A/C cg20283391 chr11:68216788 NA -0.46 -9.02 -0.34 2.24e-18 Total body bone mineral density; BRCA cis rs2764980 1.000 rs2764979 chr10:3283882 T/C cg11630169 chr10:3283847 NA -0.41 -9.36 -0.35 1.37e-19 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg27170947 chr2:26402098 FAM59B 0.97 16.86 0.55 4.94e-53 Gut microbiome composition (summer); BRCA cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.83 0.58 5.12e-58 Age-related macular degeneration (geographic atrophy); BRCA cis rs9640161 0.789 rs4554381 chr7:150025567 G/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.55 -13.86 -0.48 2.15e-38 Blood protein levels;Circulating chemerin levels; BRCA cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg20607287 chr7:12443886 VWDE -0.54 -8.21 -0.31 1.22e-15 Coronary artery disease; BRCA cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg10523679 chr1:76189770 ACADM -0.46 -8.73 -0.33 2.25e-17 Daytime sleep phenotypes; BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03934478 chr11:495069 RNH1 0.79 11.76 0.42 5.06e-29 Body mass index; BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg09060608 chr5:178986726 RUFY1 0.45 9.86 0.36 1.92e-21 Lung cancer; BRCA cis rs9837602 1.000 rs13069311 chr3:99801628 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.21 0.41 9.34e-27 Breast cancer; BRCA cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg06115741 chr20:33292138 TP53INP2 0.39 8.69 0.33 3.04e-17 Glomerular filtration rate (creatinine); BRCA cis rs3749237 1.000 rs11717256 chr3:49868520 C/T cg03060546 chr3:49711283 APEH 0.47 10.06 0.37 3.3e-22 Resting heart rate; BRCA cis rs1401999 0.628 rs1520195 chr3:183736882 G/A cg20387954 chr3:183756860 HTR3D 0.39 8.73 0.33 2.23e-17 Anterior chamber depth; BRCA cis rs9300255 0.544 rs1790123 chr12:123659542 C/T cg00376283 chr12:123451042 ABCB9 0.49 10.05 0.37 3.82e-22 Neutrophil percentage of white cells; BRCA cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg14847009 chr1:175162515 KIAA0040 0.25 9.46 0.35 5.95e-20 Alcohol dependence; BRCA cis rs2806561 0.765 rs9426692 chr1:23508426 C/T cg12483005 chr1:23474871 LUZP1 0.46 10.27 0.38 5.48e-23 Height; BRCA cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg27535305 chr1:53392650 SCP2 -0.38 -9.28 -0.34 2.59e-19 Monocyte count; BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.44 -8.9 -0.33 5.92e-18 Tonsillectomy; BRCA cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg14349672 chr11:133703707 NA 0.36 8.46 0.32 1.88e-16 Childhood ear infection; BRCA cis rs72781680 0.800 rs72790306 chr2:24111311 T/G cg08917208 chr2:24149416 ATAD2B 1.1 15.68 0.53 3.91e-47 Lymphocyte counts; BRCA cis rs9399135 1.000 rs6569988 chr6:135352303 C/A cg24558204 chr6:135376177 HBS1L 0.43 11.65 0.42 1.4e-28 Red blood cell count; BRCA cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg17330251 chr7:94953956 PON1 -0.42 -8.81 -0.33 1.22e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs858239 0.600 rs4409314 chr7:23127952 T/C cg23682824 chr7:23144976 KLHL7 0.42 11.21 0.41 9.6e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg18016565 chr1:150552671 MCL1 -0.41 -9.52 -0.35 3.58e-20 Tonsillectomy; BRCA cis rs8072100 0.713 rs9899859 chr17:45513049 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -11.98 -0.43 5.79e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1997103 1.000 rs12532070 chr7:55407698 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg02773041 chr1:40204384 PPIE 0.45 9.72 0.36 6.63e-21 Blood protein levels; BRCA trans rs1997103 1.000 rs6593238 chr7:55411048 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10751667 0.643 rs10902245 chr11:953014 C/T ch.11.42038R chr11:967971 AP2A2 -0.51 -16.12 -0.54 2.64e-49 Alzheimer's disease (late onset); BRCA cis rs5997397 0.934 rs6005863 chr22:29156448 A/G cg02153584 chr22:29168773 CCDC117 0.51 11.44 0.41 1.06e-27 Red cell distribution width; BRCA cis rs2040771 0.745 rs2283646 chr22:19273902 A/G cg02655711 chr22:19163373 SLC25A1 -0.37 -8.49 -0.32 1.41e-16 Metabolite levels (small molecules and protein measures); BRCA cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg24296786 chr1:45957014 TESK2 0.64 15.77 0.53 1.48e-47 High light scatter reticulocyte count; BRCA cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg18404041 chr3:52824283 ITIH1 -0.37 -11.27 -0.41 5.23e-27 Electroencephalogram traits; BRCA cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg04450456 chr4:17643702 FAM184B 0.38 11.37 0.41 1.99e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg07606381 chr6:8435919 SLC35B3 -0.64 -14.08 -0.49 2.01e-39 Motion sickness; BRCA cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg04455712 chr21:45112962 RRP1B 0.38 9.69 0.36 8.36e-21 Mean corpuscular volume; BRCA cis rs10911232 0.507 rs10737239 chr1:183030170 A/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.23e-51 Hypertriglyceridemia; BRCA cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg06064525 chr11:970664 AP2A2 -0.47 -15.48 -0.52 3.87e-46 Alzheimer's disease (late onset); BRCA cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg12365402 chr11:9010492 NRIP3 -0.4 -9.38 -0.35 1.14e-19 Hemoglobin concentration; BRCA cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg24562669 chr7:97807699 LMTK2 0.45 11.94 0.43 8.29e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs6728642 1.000 rs17037402 chr2:98014883 C/T cg26665480 chr2:98280029 ACTR1B -0.67 -7.91 -0.3 1.17e-14 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg24977027 chr2:88469347 THNSL2 0.46 8.01 0.3 5.36e-15 Plasma clusterin levels; BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg22920501 chr2:26401640 FAM59B -0.69 -11.69 -0.42 9.6e-29 Gut microbiome composition (summer); BRCA cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.8 -0.45 1.42e-33 Bipolar disorder; BRCA cis rs17270561 0.666 rs4712976 chr6:25842203 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 10.75 0.39 7.13e-25 Iron status biomarkers; BRCA cis rs2842992 1.000 rs2758322 chr6:160075188 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.31 0.41 3.56e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs67981189 0.727 rs221903 chr14:71600208 A/G cg15816911 chr14:71606274 NA -0.36 -8.01 -0.3 5.46e-15 Schizophrenia; BRCA cis rs2294693 0.945 rs9369252 chr6:40986028 C/T cg14418226 chr6:40996092 UNC5CL -0.45 -8.12 -0.31 2.44e-15 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs7552404 0.628 rs4949686 chr1:76473299 G/C cg03433033 chr1:76189801 ACADM 0.6 10.51 0.38 6.19e-24 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs60843830 0.661 rs62116682 chr2:104618 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.49 9.42 0.35 8.36e-20 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg22509189 chr2:225307070 NA -0.47 -9.97 -0.37 7.32e-22 IgE levels in asthmatics (D.p. specific); BRCA trans rs2204008 0.745 rs12146863 chr12:38502346 G/A cg06521331 chr12:34319734 NA -0.47 -8.73 -0.33 2.15e-17 Bladder cancer; BRCA cis rs829883 0.724 rs11109508 chr12:98905985 T/C cg25150519 chr12:98850993 NA -0.51 -9.46 -0.35 5.81e-20 Colorectal adenoma (advanced); BRCA cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg21770322 chr7:97807741 LMTK2 0.44 11.54 0.42 3.92e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs3008870 0.755 rs6657065 chr1:67384639 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.66 0.48 1.77e-37 Lymphocyte percentage of white cells; BRCA cis rs7246657 0.943 rs10405325 chr19:37883477 G/C cg23950597 chr19:37808831 NA -0.75 -13.04 -0.46 1.25e-34 Coronary artery calcification; BRCA cis rs11599315 0.507 rs12220554 chr10:1341852 C/T cg27336068 chr10:1336103 ADARB2 -0.29 -7.99 -0.3 6.44e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg14963724 chr18:72166303 CNDP2 -0.34 -7.85 -0.3 1.81e-14 Refractive error; BRCA cis rs7772486 0.754 rs702306 chr6:145991029 T/C cg13319975 chr6:146136371 FBXO30 0.4 9.31 0.35 1.97e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs9951602 0.512 rs4799248 chr18:76653459 G/A cg02800362 chr5:177631904 HNRNPAB 0.77 18.16 0.58 9.67e-60 Obesity-related traits; BRCA cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg03433033 chr1:76189801 ACADM 0.86 22.1 0.66 7.87e-81 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.06 -18.86 -0.6 1.99e-63 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg23711669 chr6:146136114 FBXO30 0.77 17.46 0.57 4.4e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg06108461 chr20:60628389 TAF4 -0.79 -17.05 -0.56 5.51e-54 Body mass index; BRCA cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg13073564 chr4:8508604 NA -0.44 -12.09 -0.43 1.85e-30 Response to antineoplastic agents; BRCA trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg26384229 chr12:38710491 ALG10B 0.58 13.18 0.46 2.85e-35 Morning vs. evening chronotype; BRCA cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg11764359 chr7:65958608 NA -0.8 -19.29 -0.61 1.12e-65 Aortic root size; BRCA cis rs67311347 1.000 rs7628796 chr3:40507332 G/A cg09455208 chr3:40491958 NA -0.48 -11.61 -0.42 2e-28 Renal cell carcinoma; BRCA cis rs1322639 0.574 rs9689193 chr6:169588074 A/G cg03254818 chr6:169586852 NA 0.52 8.11 0.31 2.65e-15 Pulse pressure; BRCA cis rs7927771 0.524 rs7114813 chr11:47801101 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs7949030 0.523 rs12223627 chr11:62368557 G/C cg13298116 chr11:62369859 EML3;MTA2 0.57 11.34 0.41 2.86e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs208520 0.690 rs1233103 chr6:66855943 T/G cg07460842 chr6:66804631 NA -1.02 -20.25 -0.63 8.06e-71 Exhaled nitric oxide output; BRCA trans rs12310956 0.532 rs1589903 chr12:33943019 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.47 0.35 5.29e-20 Morning vs. evening chronotype; BRCA cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg05347473 chr6:146136440 FBXO30 0.4 7.82 0.3 2.26e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs911119 0.913 rs3810575 chr20:23583392 G/A cg16589663 chr20:23618590 CST3 0.4 7.83 0.3 2.02e-14 Chronic kidney disease; BRCA cis rs1784581 0.802 rs9365355 chr6:162414604 A/G cg17173639 chr6:162384350 PARK2 0.39 9.12 0.34 9.27e-19 Itch intensity from mosquito bite; BRCA cis rs2795502 1.000 rs1581702 chr10:43344246 G/A cg20628663 chr10:43360327 NA 0.71 13.74 0.48 8.06e-38 Blood protein levels; BRCA cis rs8062405 0.755 rs62034355 chr16:28581038 G/C cg16576597 chr16:28551801 NUPR1 0.35 8.8 0.33 1.32e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7264396 0.790 rs2207889 chr20:34224898 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.35 -0.52 1.63e-45 Total cholesterol levels; BRCA cis rs7246967 0.673 rs57736314 chr19:22880272 T/G cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs12497850 0.931 rs12493289 chr3:48905161 G/A cg07636037 chr3:49044803 WDR6 0.98 29.03 0.75 8.19e-119 Parkinson's disease; BRCA cis rs6430585 0.527 rs2278731 chr2:136396300 T/C cg07169764 chr2:136633963 MCM6 0.98 19.22 0.61 2.54e-65 Corneal structure; BRCA cis rs7607369 0.719 rs7567622 chr2:219624549 A/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.98 -0.4 8.27e-26 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs1997103 0.834 rs10274457 chr7:55390199 G/A cg20935933 chr6:143382018 AIG1 0.61 11.61 0.42 2.03e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs17253792 0.822 rs10149408 chr14:56046075 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.71e-16 Putamen volume; BRCA cis rs9790314 1.000 rs6765269 chr3:160948542 T/C cg03342759 chr3:160939853 NMD3 -0.64 -13.5 -0.47 1.07e-36 Morning vs. evening chronotype; BRCA cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg11764359 chr7:65958608 NA 0.66 11.77 0.42 4.36e-29 Aortic root size; BRCA cis rs3008870 1.000 rs12039172 chr1:67447450 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.4 -0.66 1.71e-82 Lymphocyte percentage of white cells; BRCA cis rs7814319 0.646 rs938828 chr8:97316821 A/C cg20787634 chr8:97240163 UQCRB -0.36 -7.95 -0.3 8.26e-15 Lung function (FVC); BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.71 -0.53 2.72e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6964587 0.967 rs410 chr7:91557425 C/G cg17063962 chr7:91808500 NA -0.51 -11.81 -0.42 3.1e-29 Breast cancer; BRCA cis rs6910061 1.000 rs9468416 chr6:11100978 T/C cg27233058 chr6:11094804 LOC221710 0.52 9.3 0.35 2.15e-19 Diabetic kidney disease; BRCA cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg03709012 chr19:19516395 GATAD2A 0.73 16.31 0.54 2.86e-50 Tonsillectomy; BRCA cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA cis rs12618769 0.597 rs3769713 chr2:99151434 A/G cg10123293 chr2:99228465 UNC50 0.42 8.33 0.31 5e-16 Bipolar disorder; BRCA cis rs7246967 0.673 rs34726149 chr19:22952111 A/G cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA trans rs1325195 0.920 rs2793797 chr1:179097206 A/G cg11624085 chr17:8464688 MYH10 0.26 7.85 0.3 1.81e-14 IgE grass sensitization; BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg22903471 chr2:27725779 GCKR -0.39 -9.75 -0.36 5.1e-21 Total body bone mineral density; BRCA cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg23711669 chr6:146136114 FBXO30 0.81 19.41 0.61 2.43e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs7520050 0.778 rs12404197 chr1:46232420 G/A cg24296786 chr1:45957014 TESK2 0.45 10.35 0.38 2.6e-23 Red blood cell count;Reticulocyte count; BRCA cis rs9309473 0.519 rs2178154 chr2:73661738 C/T cg20560298 chr2:73613845 ALMS1 0.42 11.32 0.41 3.42e-27 Metabolite levels; BRCA cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg20701182 chr2:24300061 SF3B14 0.63 9.18 0.34 6.15e-19 Lymphocyte counts; BRCA cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg11584989 chr19:19387371 SF4 -0.62 -13.5 -0.47 1e-36 Bipolar disorder; BRCA cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.03 0.3 4.78e-15 Breast cancer; BRCA cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg11764359 chr7:65958608 NA -0.67 -14.7 -0.5 2.39e-42 Aortic root size; BRCA cis rs1371614 0.635 rs9309558 chr2:27141504 C/T cg00617064 chr2:27272375 NA 0.31 8.03 0.3 4.78e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2425143 1.000 rs11696369 chr20:34378629 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.96 -0.37 8.33e-22 Blood protein levels; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.0 -0.34 2.59e-18 Total body bone mineral density; BRCA cis rs270601 0.837 rs367805 chr5:131701279 T/C cg07395648 chr5:131743802 NA -0.36 -8.03 -0.3 4.6e-15 Acylcarnitine levels; BRCA cis rs13315871 1.000 rs11708590 chr3:58336635 A/G cg20936604 chr3:58311152 NA 0.62 8.05 0.3 3.94e-15 Cholesterol, total; BRCA trans rs801193 0.904 rs4718403 chr7:66242729 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.27 0.31 7.64e-16 Aortic root size; BRCA cis rs7903847 0.620 rs17112676 chr10:99122288 G/A cg08345082 chr10:99160200 RRP12 -0.28 -8.04 -0.3 4.32e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs78761021 0.720 rs874307 chr17:9798074 C/G cg26853458 chr17:9805074 RCVRN 0.47 9.6 0.35 1.81e-20 Type 2 diabetes; BRCA cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg09184832 chr6:79620586 NA -0.5 -11.14 -0.4 1.91e-26 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.733 rs801181 chr5:140092814 C/T cg11822812 chr5:140052017 DND1 -0.3 -8.37 -0.31 3.58e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs7772486 0.875 rs865913 chr6:146308874 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -8.59 -0.32 6.86e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.55 -0.32 9.24e-17 Total body bone mineral density; BRCA cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.54 -11.51 -0.41 5.36e-28 Colorectal cancer; BRCA cis rs9399135 0.967 rs3756799 chr6:135341011 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.59e-31 Red blood cell count; BRCA cis rs17376456 1.000 rs13185608 chr5:93509688 T/G cg21475434 chr5:93447410 FAM172A 0.73 9.1 0.34 1.14e-18 Diabetic retinopathy; BRCA cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg04455712 chr21:45112962 RRP1B 0.45 12.16 0.43 9.3e-31 Mean corpuscular volume; BRCA cis rs2180341 1.000 rs4895822 chr6:127642703 T/C cg24812749 chr6:127587940 RNF146 0.88 20.75 0.63 1.58e-73 Breast cancer; BRCA cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 9.16 0.34 7.19e-19 Platelet count; BRCA cis rs6430585 0.640 rs3816155 chr2:136552526 A/C cg07169764 chr2:136633963 MCM6 -1.15 -25.86 -0.72 1.77e-101 Corneal structure; BRCA cis rs7809950 1.000 rs2520271 chr7:107194949 C/T cg23024343 chr7:107201750 COG5 -0.4 -9.05 -0.34 1.71e-18 Coronary artery disease; BRCA cis rs11608355 0.515 rs2270361 chr12:109935894 G/C cg05360138 chr12:110035743 NA 0.72 13.3 0.47 8.56e-36 Neuroticism; BRCA cis rs250677 0.652 rs168751 chr5:148438264 C/T cg18129178 chr5:148520854 ABLIM3 -0.65 -13.22 -0.46 1.85e-35 Breast cancer; BRCA cis rs11190604 0.945 rs2495746 chr10:102328270 T/C cg07080220 chr10:102295463 HIF1AN 0.54 12.43 0.44 6.6e-32 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg25036284 chr2:26402008 FAM59B -0.64 -10.59 -0.39 3.03e-24 Gut microbiome composition (summer); BRCA cis rs7246657 0.722 rs8103647 chr19:38100452 C/A cg14683738 chr19:37701593 ZNF585B 0.47 8.07 0.3 3.44e-15 Coronary artery calcification; BRCA cis rs8018808 0.935 rs12436593 chr14:77928476 C/T cg20045696 chr14:77926864 AHSA1 0.36 8.4 0.32 2.91e-16 Myeloid white cell count; BRCA cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg00677455 chr12:58241039 CTDSP2 0.52 11.61 0.42 1.98e-28 Intelligence (multi-trait analysis); BRCA cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg18305652 chr10:134549665 INPP5A 0.51 13.31 0.47 7.68e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg10932868 chr11:921992 NA 0.5 12.8 0.45 1.56e-33 Alzheimer's disease (late onset); BRCA cis rs514406 0.893 rs512723 chr1:53343880 C/T cg01802117 chr1:53393560 SCP2 0.37 8.17 0.31 1.7e-15 Monocyte count; BRCA cis rs6429082 0.818 rs291341 chr1:235663174 G/T cg26050004 chr1:235667680 B3GALNT2 0.58 13.5 0.47 9.72e-37 Adiposity; BRCA cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg17063962 chr7:91808500 NA 0.52 12.41 0.44 7.57e-32 Breast cancer; BRCA cis rs1865760 0.865 rs1541987 chr6:25950397 A/G cg17691542 chr6:26056736 HIST1H1C -0.47 -9.62 -0.36 1.45e-20 Height; BRCA cis rs1215050 0.740 rs9994227 chr4:98767094 T/G cg05340658 chr4:99064831 C4orf37 0.45 10.23 0.38 7.78e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -17.64 -0.57 5.13e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs7677751 0.806 rs73252942 chr4:55104604 T/C cg17187183 chr4:55093834 PDGFRA 0.44 9.1 0.34 1.14e-18 Corneal astigmatism; BRCA cis rs912057 0.833 rs1294426 chr6:6744477 T/C cg06612196 chr6:6737390 NA 0.4 8.87 0.33 7.1e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs921968 0.541 rs549026 chr2:219339283 T/C cg02176678 chr2:219576539 TTLL4 0.46 11.86 0.42 1.84e-29 Mean corpuscular hemoglobin concentration; BRCA trans rs7746199 0.736 rs13210634 chr6:27646492 A/G cg06606381 chr12:133084897 FBRSL1 -0.89 -8.8 -0.33 1.28e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs4664304 0.739 rs2162500 chr2:160708645 C/G cg18514922 chr2:160761262 LY75 0.33 7.81 0.3 2.41e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.79 -0.33 1.38e-17 Total body bone mineral density; BRCA cis rs2279817 1.000 rs1339800 chr1:18020201 C/G cg21791023 chr1:18019539 ARHGEF10L -0.55 -16.49 -0.55 3.48e-51 Neuroticism; BRCA cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg27286337 chr10:134555280 INPP5A 0.79 12.8 0.45 1.5e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9660992 0.626 rs61823972 chr1:205201325 A/C cg00857998 chr1:205179979 DSTYK 0.41 8.03 0.3 4.67e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg06618935 chr21:46677482 NA -0.38 -8.24 -0.31 9.59e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg07828340 chr4:882639 GAK 1.04 12.4 0.44 8.99e-32 Intelligence (multi-trait analysis); BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.85 -0.3 1.74e-14 Total body bone mineral density; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg11062466 chr8:58055876 NA 0.5 8.72 0.33 2.44e-17 Developmental language disorder (linguistic errors); BRCA cis rs6430585 0.583 rs60253740 chr2:136571852 G/T cg07169764 chr2:136633963 MCM6 1.22 28.8 0.75 1.57e-117 Corneal structure; BRCA cis rs875971 0.862 rs778702 chr7:65864835 G/A cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg19539972 chr4:7069911 GRPEL1 0.72 17.53 0.57 1.79e-56 Monocyte percentage of white cells; BRCA cis rs11098499 0.657 rs10434028 chr4:120294464 T/G cg09307838 chr4:120376055 NA 0.67 14.49 0.5 2.48e-41 Corneal astigmatism; BRCA cis rs796364 0.570 rs4673491 chr2:200669108 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.58 8.72 0.33 2.3e-17 Schizophrenia; BRCA cis rs11098499 0.909 rs10017335 chr4:120381523 C/G cg09307838 chr4:120376055 NA -0.75 -15.75 -0.53 1.77e-47 Corneal astigmatism; BRCA cis rs12711979 0.765 rs897069 chr2:3818947 C/T cg17052675 chr2:3827356 NA 0.48 14.17 0.49 8.2e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg04944784 chr2:26401820 FAM59B 1.0 16.52 0.55 2.51e-51 Gut microbiome composition (summer); BRCA cis rs10751667 0.643 rs7395592 chr11:934094 C/G cg01483505 chr11:975446 AP2A2 0.3 8.18 0.31 1.58e-15 Alzheimer's disease (late onset); BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg04944784 chr2:26401820 FAM59B 1.01 16.64 0.55 6.66e-52 Gut microbiome composition (summer); BRCA cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg23711669 chr6:146136114 FBXO30 0.74 15.78 0.53 1.37e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 1.000 rs2297496 chr20:25295787 T/C cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4363385 0.693 rs418550 chr1:153048045 A/T cg24667326 chr1:152973720 SPRR3 -0.29 -7.87 -0.3 1.56e-14 Inflammatory skin disease; BRCA cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg09469691 chr10:81107165 PPIF 0.46 9.98 0.37 6.89e-22 Height; BRCA trans rs7241530 0.623 rs2411419 chr18:75917133 C/T cg25697769 chr22:39097335 JOSD1 -0.37 -8.06 -0.3 3.89e-15 Educational attainment (years of education); BRCA cis rs4363385 0.747 rs11205151 chr1:152961496 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.39 -0.32 3.01e-16 Inflammatory skin disease; BRCA cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg16405210 chr4:1374714 KIAA1530 -0.47 -10.84 -0.39 2.9e-25 Longevity; BRCA cis rs2859741 0.546 rs2134846 chr1:37500723 G/A cg09363841 chr1:37513479 NA -0.53 -11.38 -0.41 1.93e-27 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg16414030 chr3:133502952 NA -0.48 -11.23 -0.41 7.89e-27 Iron status biomarkers; BRCA cis rs1878931 0.507 rs1218762 chr16:3405986 G/A cg02880119 chr16:3481970 NA 0.42 7.97 0.3 7.52e-15 Body mass index (adult); BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg12648201 chr2:27665141 KRTCAP3 -0.32 -7.88 -0.3 1.46e-14 Menopause (age at onset); BRCA cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg22508957 chr16:3507546 NAT15 -0.39 -9.05 -0.34 1.74e-18 Tuberculosis; BRCA cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -8.97 -0.33 3.21e-18 IgG glycosylation; BRCA cis rs3772130 0.962 rs6776670 chr3:121543120 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.95 0.4 1.05e-25 Cognitive performance; BRCA cis rs4660306 1.000 rs882803 chr1:45976147 G/A cg24296786 chr1:45957014 TESK2 0.43 8.98 0.33 3.04e-18 Homocysteine levels; BRCA cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg12011299 chr4:100065546 ADH4 -0.5 -11.63 -0.42 1.67e-28 Alcohol dependence; BRCA cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs9399137 0.507 rs28384513 chr6:135376209 T/G cg22676075 chr6:135203613 NA 0.45 8.89 0.33 6.18e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs400736 0.602 rs4601608 chr1:8168808 A/G cg25007680 chr1:8021821 PARK7 -0.35 -8.68 -0.32 3.37e-17 Response to antidepressants and depression; BRCA cis rs11051970 0.838 rs2651369 chr12:32552769 C/G cg24626660 chr12:32551988 NA 0.33 9.08 0.34 1.39e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -11.9 -0.43 1.26e-29 Bipolar disorder; BRCA cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg01802117 chr1:53393560 SCP2 -0.36 -8.38 -0.31 3.43e-16 Monocyte count; BRCA cis rs2204008 0.536 rs12368354 chr12:38042798 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.91 0.56 2.6e-53 Bladder cancer; BRCA cis rs829883 1.000 rs2908843 chr12:98889332 C/G cg25150519 chr12:98850993 NA -0.58 -11.93 -0.43 9e-30 Colorectal adenoma (advanced); BRCA cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.94 -0.3 9.42e-15 Bipolar disorder; BRCA cis rs7666738 0.830 rs6855393 chr4:99056534 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.96 0.4 9.71e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.03e-18 Height; BRCA cis rs1801251 0.963 rs6739638 chr2:233576015 G/A cg25237894 chr2:233734115 C2orf82 0.4 11.38 0.41 1.84e-27 Coronary artery disease; BRCA cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg21573476 chr21:45109991 RRP1B 0.35 9.07 0.34 1.49e-18 Mean corpuscular volume; BRCA cis rs6433895 0.677 rs35725888 chr2:181998627 T/C cg00481216 chr2:181971175 NA 0.46 8.68 0.32 3.35e-17 Lymphocyte counts; BRCA cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg05347473 chr6:146136440 FBXO30 0.41 7.93 0.3 1.01e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs495337 0.797 rs2025958 chr20:48456238 G/A cg17835207 chr20:48524531 SPATA2 0.5 10.94 0.4 1.22e-25 Psoriasis; BRCA cis rs3768617 0.510 rs2296288 chr1:183072590 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 17.68 0.57 3.1e-57 Fuchs's corneal dystrophy; BRCA trans rs9325144 0.532 rs12812406 chr12:38719802 G/A cg23762105 chr12:34175262 ALG10 0.36 8.41 0.32 2.64e-16 Morning vs. evening chronotype; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg07308232 chr7:1071921 C7orf50 -0.36 -7.98 -0.3 6.88e-15 Longevity;Endometriosis; BRCA cis rs1003719 0.680 rs1034357 chr21:38571482 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA trans rs11098499 0.779 rs10016060 chr4:120298412 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs12541635 1.000 rs4734897 chr8:107075518 G/A cg10147462 chr8:107024639 NA -0.31 -8.59 -0.32 6.77e-17 Age of smoking initiation; BRCA cis rs4363385 0.747 rs7529110 chr1:152966247 A/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.6 -0.35 1.81e-20 Inflammatory skin disease; BRCA cis rs9467773 1.000 rs3736781 chr6:26505362 G/A cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.23e-60 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg23708337 chr7:1209742 NA 0.43 8.23 0.31 1.05e-15 Longevity;Endometriosis; BRCA cis rs782590 0.837 rs809732 chr2:55914621 T/C cg18811423 chr2:55921094 PNPT1 0.77 26.65 0.73 8.68e-106 Metabolic syndrome; BRCA cis rs1113500 0.548 rs7541433 chr1:108645641 G/A cg06207961 chr1:108661230 NA 0.36 7.83 0.3 2.03e-14 Growth-regulated protein alpha levels; BRCA cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg25173405 chr17:45401733 C17orf57 -0.53 -11.03 -0.4 5.02e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2882667 0.929 rs34846849 chr5:138360578 T/C cg04439458 chr5:138467593 SIL1 -0.42 -10.59 -0.39 2.86e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs11976180 1.000 rs1533267 chr7:143766440 A/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.44 -8.25 -0.31 9.11e-16 Obesity-related traits; BRCA cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg26149184 chr10:133730230 NA 0.41 8.27 0.31 7.64e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -10.83 -0.39 3.37e-25 Chronic sinus infection; BRCA cis rs7301826 0.651 rs10848209 chr12:131311272 A/G cg11011512 chr12:131303247 STX2 0.49 12.97 0.46 2.58e-34 Plasma plasminogen activator levels; BRCA cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg24562669 chr7:97807699 LMTK2 -0.49 -13.28 -0.46 1.07e-35 Breast cancer; BRCA cis rs12612619 0.579 rs6756245 chr2:27083489 C/T cg12368169 chr2:27073192 DPYSL5 0.34 10.51 0.38 5.99e-24 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7903847 0.642 rs11189192 chr10:99149403 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.86 -0.33 7.8e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs7267979 1.000 rs6050626 chr20:25428261 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.23 0.34 4.02e-19 Liver enzyme levels (alkaline phosphatase); BRCA trans rs9929218 0.954 rs112225541 chr16:68755165 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.78 -15.93 -0.53 2.21e-48 Colorectal cancer; BRCA cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg13298116 chr11:62369859 EML3;MTA2 0.56 12.79 0.45 1.56e-33 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12760731 0.720 rs12755909 chr1:178305298 G/A cg00404053 chr1:178313656 RASAL2 0.69 8.64 0.32 4.35e-17 Obesity-related traits; BRCA cis rs701145 0.585 rs1624917 chr3:153827300 T/A cg17054900 chr3:154042577 DHX36 0.53 9.04 0.34 1.88e-18 Coronary artery disease; BRCA cis rs11920090 0.932 rs16855578 chr3:170684592 A/G cg09710316 chr3:170744871 SLC2A2 0.41 7.93 0.3 9.56e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs6963495 0.818 rs117845382 chr7:105152040 T/C cg19920283 chr7:105172520 RINT1 0.58 9.35 0.35 1.42e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7085104 0.632 rs3781287 chr10:104595420 A/C cg04362960 chr10:104952993 NT5C2 0.38 9.17 0.34 6.42e-19 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg18252515 chr7:66147081 NA -0.35 -7.82 -0.3 2.15e-14 Aortic root size; BRCA cis rs10206020 0.885 rs6746052 chr2:1576811 T/C cg26248373 chr2:1572462 NA -0.62 -14.37 -0.49 8.48e-41 IgG glycosylation; BRCA trans rs7647973 0.710 rs11130208 chr3:49615624 G/T cg21659725 chr3:3221576 CRBN -0.49 -8.5 -0.32 1.31e-16 Menarche (age at onset); BRCA cis rs2249625 0.545 rs2496488 chr6:72875985 A/T cg18830697 chr6:72922368 RIMS1 -0.64 -14.66 -0.5 3.57e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg10495392 chr1:46806563 NSUN4 0.46 8.31 0.31 5.8e-16 Menopause (age at onset); BRCA cis rs113835537 0.529 rs2276406 chr11:66283257 C/T cg24851651 chr11:66362959 CCS 0.44 8.29 0.31 6.92e-16 Airway imaging phenotypes; BRCA cis rs796364 0.806 rs11689664 chr2:201099961 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -9.16 -0.34 6.97e-19 Schizophrenia; BRCA cis rs476633 0.691 rs28568756 chr15:41539371 G/A cg18705301 chr15:41695430 NDUFAF1 -0.39 -8.61 -0.32 5.68e-17 Glomerular filtration rate (creatinine); BRCA trans rs6601327 0.573 rs13278824 chr8:9646119 T/A cg06636001 chr8:8085503 FLJ10661 0.38 7.99 0.3 6.18e-15 Multiple myeloma (hyperdiploidy); BRCA cis rs9403521 0.947 rs7741424 chr6:143981662 G/A cg18240653 chr6:144019428 PHACTR2 -0.4 -7.81 -0.3 2.34e-14 Obesity-related traits; BRCA cis rs6543140 0.865 rs6760275 chr2:103079607 C/T cg04239558 chr2:103089729 SLC9A4 0.35 9.74 0.36 5.21e-21 Blood protein levels; BRCA cis rs13046373 0.535 rs2832970 chr21:32020767 T/C cg16812893 chr21:31813075 KRTAP15-1 0.37 9.28 0.34 2.58e-19 HDL cholesterol; BRCA cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.87 0.33 7.01e-18 Bladder cancer; BRCA cis rs79976124 0.837 rs12201218 chr6:66653619 C/T cg07460842 chr6:66804631 NA -0.6 -10.43 -0.38 1.22e-23 Type 2 diabetes; BRCA cis rs10883723 0.810 rs3740406 chr10:104272789 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.13 0.62 3.46e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs17401966 1.000 rs12141416 chr1:10327867 A/G cg19773385 chr1:10388646 KIF1B -0.36 -7.92 -0.3 1.05e-14 Hepatocellular carcinoma; BRCA cis rs453301 0.606 rs7462373 chr8:8899318 G/C cg06636001 chr8:8085503 FLJ10661 -0.48 -10.29 -0.38 4.23e-23 Joint mobility (Beighton score); BRCA cis rs4680 1.000 rs4680 chr22:19951271 C/T cg23601416 chr22:19950040 COMT 0.3 10.18 0.37 1.12e-22 Blood metabolite levels; BRCA cis rs11190604 0.767 rs7392696 chr10:102182141 G/A cg07080220 chr10:102295463 HIF1AN 0.5 10.36 0.38 2.43e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs8038465 0.622 rs60696711 chr15:73873005 C/A cg15420318 chr15:73925796 NPTN 0.46 10.0 0.37 5.74e-22 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17641971 0.684 rs7011891 chr8:49983538 A/C cg00325661 chr8:49890786 NA 0.38 10.58 0.39 3.22e-24 Blood metabolite levels; BRCA cis rs67460515 0.563 rs11713441 chr3:160906855 T/C cg03342759 chr3:160939853 NMD3 -0.74 -15.69 -0.53 3.72e-47 Parkinson's disease; BRCA cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13732083 chr21:47605072 C21orf56 -0.4 -8.16 -0.31 1.79e-15 Testicular germ cell tumor; BRCA cis rs1401999 1.000 rs6443924 chr3:183679532 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.08 0.37 2.84e-22 Anterior chamber depth; BRCA cis rs7945705 0.806 rs12224436 chr11:8815825 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.49 10.44 0.38 1.18e-23 Hemoglobin concentration; BRCA cis rs2204008 0.774 rs7305085 chr12:38263511 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs57590327 0.555 rs11127740 chr3:81743062 A/C cg07356753 chr3:81810745 GBE1 -0.46 -10.93 -0.4 1.32e-25 Extraversion; BRCA cis rs4808199 0.948 rs7250368 chr19:19452763 G/A cg01262667 chr19:19385393 TM6SF2 0.38 8.16 0.31 1.83e-15 Nonalcoholic fatty liver disease; BRCA cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg25173405 chr17:45401733 C17orf57 0.55 11.33 0.41 3.06e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs67981189 0.593 rs2526883 chr14:71369575 T/G cg15816911 chr14:71606274 NA -0.39 -8.92 -0.33 5.03e-18 Schizophrenia; BRCA cis rs5758659 0.714 rs5758589 chr22:42518382 A/G cg04733989 chr22:42467013 NAGA -0.37 -8.27 -0.31 7.52e-16 Cognitive function; BRCA cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.09 0.56 3.19e-54 Bladder cancer; BRCA cis rs9814567 0.806 rs11927540 chr3:134319455 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.33 -8.12 -0.31 2.37e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7582180 0.614 rs3748930 chr2:101010082 G/C cg14675211 chr2:100938903 LONRF2 0.43 9.72 0.36 6.38e-21 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg02659138 chr7:134003124 SLC35B4 0.35 10.85 0.39 2.84e-25 Mean platelet volume; BRCA trans rs2204008 0.715 rs3899385 chr12:38169880 C/G cg06521331 chr12:34319734 NA -0.5 -9.31 -0.35 1.97e-19 Bladder cancer; BRCA cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg03213289 chr20:61660250 NA 0.6 15.7 0.53 3.15e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg16989086 chr20:62203971 PRIC285 -0.51 -8.61 -0.32 5.85e-17 Glioblastoma; BRCA cis rs10493773 0.618 rs17394091 chr1:86075098 A/G cg17807903 chr1:86174739 ZNHIT6 -0.43 -8.15 -0.31 1.96e-15 Urate levels in overweight individuals; BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.46 9.2 0.34 5e-19 Lymphocyte counts; BRCA cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg23788917 chr6:8435910 SLC35B3 0.49 10.61 0.39 2.48e-24 Motion sickness; BRCA cis rs7560272 0.723 rs13386124 chr2:73771695 C/G cg20560298 chr2:73613845 ALMS1 -0.37 -9.14 -0.34 7.93e-19 Schizophrenia; BRCA cis rs2404602 0.692 rs3110382 chr15:77148688 G/A cg26408565 chr15:76604113 ETFA 0.37 7.92 0.3 1.03e-14 Blood metabolite levels; BRCA cis rs5997397 1.000 rs5997397 chr22:29154455 A/G cg02153584 chr22:29168773 CCDC117 0.46 9.85 0.36 2.09e-21 Red cell distribution width; BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg21143896 chr7:2802374 GNA12 -0.36 -8.98 -0.33 2.94e-18 Height; BRCA trans rs208520 0.661 rs851466 chr6:66840476 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.02 -0.64 6.06e-75 Exhaled nitric oxide output; BRCA cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg13319975 chr6:146136371 FBXO30 -0.34 -7.99 -0.3 6.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9811920 0.515 rs792836 chr3:99476384 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.96 -0.37 8.22e-22 Axial length; BRCA cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg25251562 chr2:3704773 ALLC 0.43 8.0 0.3 5.97e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs6543140 0.964 rs4851593 chr2:103089227 C/T cg04239558 chr2:103089729 SLC9A4 -0.35 -9.81 -0.36 2.88e-21 Blood protein levels; BRCA cis rs67460515 0.563 rs73023235 chr3:160864123 G/A cg03342759 chr3:160939853 NMD3 -0.73 -14.56 -0.5 1.05e-41 Parkinson's disease; BRCA cis rs12549902 0.966 rs4317621 chr8:41516581 A/G cg21772509 chr8:41503840 NKX6-3 0.44 10.27 0.38 5.16e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA trans rs7824557 0.815 rs958648 chr8:11103895 A/G cg06636001 chr8:8085503 FLJ10661 -0.37 -7.84 -0.3 1.92e-14 Retinal vascular caliber; BRCA cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg00409905 chr10:38381863 ZNF37A 0.45 9.21 0.34 4.65e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg00631329 chr6:26305371 NA 0.44 13.11 0.46 6.06e-35 Educational attainment; BRCA cis rs6840360 0.554 rs6849111 chr4:152708874 T/C cg22705602 chr4:152727874 NA -0.4 -10.76 -0.39 6.21e-25 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.655 rs2330103 chr21:46694514 C/T cg11663144 chr21:46675770 NA -0.47 -11.33 -0.41 2.93e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg04034577 chr2:241836375 C2orf54 -0.57 -13.89 -0.48 1.58e-38 Urinary metabolites; BRCA cis rs11792861 0.816 rs2275637 chr9:111696043 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.97 0.3 7.27e-15 Menarche (age at onset); BRCA cis rs2637266 0.935 rs751770 chr10:78393956 A/G cg18941641 chr10:78392320 NA 0.35 7.89 0.3 1.33e-14 Pulmonary function; BRCA cis rs943466 1.000 rs61662306 chr6:33746697 G/A cg25922239 chr6:33757077 LEMD2 -0.39 -7.84 -0.3 1.85e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.09 31.24 0.78 8.57e-131 Cognitive ability; BRCA cis rs9790314 0.638 rs17236725 chr3:160637935 C/T cg03342759 chr3:160939853 NMD3 0.43 8.63 0.32 4.89e-17 Morning vs. evening chronotype; BRCA cis rs295140 0.546 rs295137 chr2:201150040 C/T cg23649088 chr2:200775458 C2orf69 0.41 8.53 0.32 1.03e-16 QT interval; BRCA cis rs2933343 0.553 rs35979399 chr3:128697313 G/A cg11901034 chr3:128598214 ACAD9 -0.34 -8.09 -0.3 3.12e-15 IgG glycosylation; BRCA trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.89 -0.3 1.33e-14 Corneal astigmatism; BRCA cis rs910316 0.967 rs4899550 chr14:75647666 C/T cg23033748 chr14:75592666 NEK9 -0.42 -10.06 -0.37 3.33e-22 Height; BRCA cis rs11098499 0.954 rs6820115 chr4:120398182 T/C cg09307838 chr4:120376055 NA 0.69 15.42 0.52 7.61e-46 Corneal astigmatism; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg22907277 chr7:1156413 C7orf50 0.59 9.19 0.34 5.4e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs61931739 0.534 rs1912773 chr12:34097401 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.4 0.35 9.65e-20 Morning vs. evening chronotype; BRCA cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg12386194 chr3:101231763 SENP7 0.62 12.23 0.44 4.82e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs701145 0.585 rs357482 chr3:153889855 A/G cg17054900 chr3:154042577 DHX36 0.55 9.17 0.34 6.32e-19 Coronary artery disease; BRCA cis rs8062405 1.000 rs4788102 chr16:28873398 G/A cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg04267008 chr7:1944627 MAD1L1 -0.58 -12.19 -0.43 6.74e-31 Bipolar disorder and schizophrenia; BRCA cis rs9287719 0.967 rs11674433 chr2:10730839 T/C cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.03e-23 Prostate cancer; BRCA cis rs875971 0.540 rs4717275 chr7:65265180 C/T cg11764359 chr7:65958608 NA -0.61 -13.26 -0.46 1.22e-35 Aortic root size; BRCA cis rs2479724 0.846 rs2254805 chr6:41846110 T/G cg17623882 chr6:41773611 USP49 -0.34 -9.11 -0.34 1.08e-18 Menarche (age at onset); BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.89 16.34 0.54 2.15e-50 Platelet count; BRCA cis rs17601876 0.545 rs10851498 chr15:51537012 T/C cg19946085 chr15:51559439 CYP19A1 -0.31 -8.28 -0.31 6.98e-16 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6866344 0.697 rs6873150 chr5:178125704 G/A cg03877680 chr5:178157825 ZNF354A 0.76 14.28 0.49 2.49e-40 Neutrophil percentage of white cells; BRCA cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg14458575 chr2:238380390 NA 0.55 12.29 0.44 2.55e-31 Prostate cancer; BRCA cis rs6430585 0.527 rs62168833 chr2:136449254 G/A cg07169764 chr2:136633963 MCM6 1.0 19.33 0.61 6.73e-66 Corneal structure; BRCA cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg23711669 chr6:146136114 FBXO30 0.78 18.68 0.59 1.85e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs10876993 0.890 rs810204 chr12:58075733 T/C cg18357645 chr12:58087776 OS9 0.47 13.47 0.47 1.45e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs10740039 0.768 rs7895268 chr10:62463237 T/C cg02922035 chr10:62493342 NA 0.41 7.93 0.3 1.01e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg08213375 chr14:104286397 PPP1R13B 0.64 17.88 0.58 2.77e-58 Schizophrenia; BRCA cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg10802521 chr3:52805072 NEK4 -0.34 -9.17 -0.34 6.31e-19 Bipolar disorder; BRCA cis rs13046373 0.507 rs8133828 chr21:32033046 C/G cg24082983 chr21:31802169 KRTAP13-4 0.34 8.12 0.31 2.41e-15 HDL cholesterol; BRCA cis rs71386921 1 rs71386921 chr10:27478698 AAT/A cg14442939 chr10:27389572 ANKRD26 0.68 12.58 0.45 1.45e-32 Breast cancer; BRCA cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg12373951 chr3:133503437 NA -0.43 -10.32 -0.38 3.42e-23 Iron status biomarkers; BRCA cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg11764359 chr7:65958608 NA 0.74 16.83 0.55 6.92e-53 Aortic root size; BRCA cis rs920590 0.721 rs920587 chr8:19663339 C/A cg03894339 chr8:19674705 INTS10 0.44 8.65 0.32 4.29e-17 Acute lymphoblastic leukemia (childhood); BRCA cis rs3617 0.625 rs56019197 chr3:52874753 T/C cg11645453 chr3:52864694 ITIH4 -0.38 -9.89 -0.36 1.44e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.19 0.31 1.45e-15 Mean platelet volume; BRCA cis rs7833790 0.654 rs6415652 chr8:82702257 G/A cg17211192 chr8:82754475 SNX16 -0.54 -11.56 -0.42 3.52e-28 Diastolic blood pressure; BRCA cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg07395648 chr5:131743802 NA -0.39 -8.4 -0.32 2.91e-16 Breast cancer; BRCA cis rs4363385 0.818 rs426360 chr1:153014710 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.14 -0.34 7.95e-19 Inflammatory skin disease; BRCA cis rs8180040 0.966 rs11710322 chr3:47331136 C/T cg27129171 chr3:47204927 SETD2 -0.7 -16.68 -0.55 3.96e-52 Colorectal cancer; BRCA cis rs9790314 0.875 rs336580 chr3:161082982 A/T cg03342759 chr3:160939853 NMD3 -0.55 -12.11 -0.43 1.58e-30 Morning vs. evening chronotype; BRCA cis rs6580649 1.000 rs9805048 chr12:48403692 C/T cg24011408 chr12:48396354 COL2A1 0.53 9.62 0.36 1.48e-20 Lung cancer; BRCA cis rs7474896 0.515 rs594594 chr10:38307723 A/G cg25427524 chr10:38739819 LOC399744 0.55 10.12 0.37 1.94e-22 Obesity (extreme); BRCA cis rs8180040 0.764 rs62246375 chr3:47014464 G/A cg27129171 chr3:47204927 SETD2 -0.7 -16.76 -0.55 1.65e-52 Colorectal cancer; BRCA cis rs2243480 1.000 rs316317 chr7:65613637 G/T cg18252515 chr7:66147081 NA -1.04 -15.49 -0.52 3.67e-46 Diabetic kidney disease; BRCA cis rs4389656 0.857 rs274715 chr5:6723429 C/T cg10857441 chr5:6722123 POLS 0.25 7.83 0.3 1.98e-14 Coronary artery disease; BRCA cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg08601574 chr20:25228251 PYGB 0.35 8.44 0.32 2.13e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs758324 0.891 rs652839 chr5:131281106 G/C cg06307176 chr5:131281290 NA -0.58 -12.25 -0.44 3.79e-31 Alzheimer's disease in APOE e4- carriers; BRCA cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.15 0.37 1.5e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg13736514 chr6:26305472 NA -0.46 -14.83 -0.51 5.7e-43 Educational attainment; BRCA cis rs9875589 0.509 rs1601870 chr3:14024162 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.31 8.4 0.32 2.99e-16 Ovarian reserve; BRCA cis rs877282 0.735 rs111609055 chr10:826539 A/G cg15764593 chr10:829463 NA -0.6 -10.12 -0.37 1.94e-22 Uric acid levels; BRCA cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11644478 chr21:40555479 PSMG1 -0.67 -15.12 -0.51 2.35e-44 Cognitive function; BRCA cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg12516959 chr21:47718080 NA -0.43 -9.91 -0.37 1.21e-21 Testicular germ cell tumor; BRCA cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg26587870 chr6:27730563 NA -0.41 -8.79 -0.33 1.38e-17 Parkinson's disease; BRCA cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 10.95 0.4 1.1e-25 Rheumatoid arthritis; BRCA cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 19.49 0.61 9.39e-67 Platelet count; BRCA cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg15352829 chr14:105391018 PLD4 -0.36 -11.51 -0.41 5.24e-28 Rheumatoid arthritis; BRCA cis rs13046373 0.535 rs9977510 chr21:32027920 A/G cg06468780 chr21:31798236 KRTAP13-3 0.34 8.29 0.31 6.65e-16 HDL cholesterol; BRCA cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg12386194 chr3:101231763 SENP7 0.45 9.55 0.35 2.72e-20 Colorectal cancer; BRCA cis rs1506636 0.646 rs805779 chr7:123214835 C/T cg03229431 chr7:123269106 ASB15 -0.59 -12.65 -0.45 6.73e-33 Plateletcrit;Platelet count; BRCA trans rs9325144 0.555 rs6582607 chr12:38717678 T/C cg23762105 chr12:34175262 ALG10 0.36 8.41 0.32 2.64e-16 Morning vs. evening chronotype; BRCA cis rs11585357 0.501 rs17458002 chr1:17591524 A/G cg08277548 chr1:17600880 PADI3 -0.57 -8.0 -0.3 5.66e-15 Hair shape; BRCA cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg10523679 chr1:76189770 ACADM 0.78 18.67 0.59 1.96e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2346177 0.519 rs13003074 chr2:46671420 A/T cg06386533 chr2:46925753 SOCS5 -0.4 -7.82 -0.3 2.17e-14 HDL cholesterol; BRCA cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.38 0.38 1.95e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs2197308 0.740 rs11182967 chr12:37935140 A/C cg06521331 chr12:34319734 NA -0.53 -9.52 -0.35 3.46e-20 Morning vs. evening chronotype; BRCA cis rs16976116 0.851 rs28784096 chr15:55503312 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.52 0.38 5.59e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs75229567 0.618 rs11177849 chr12:70182473 C/T cg10114359 chr12:70132523 RAB3IP -0.75 -10.27 -0.38 5.28e-23 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs7258465 1.000 rs34171762 chr19:18559410 G/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.79 -0.33 1.35e-17 Breast cancer; BRCA cis rs4481887 0.830 rs4916126 chr1:248466604 G/A cg13385794 chr1:248469461 NA 0.28 7.81 0.3 2.28e-14 Common traits (Other); BRCA cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg22467129 chr15:76604101 ETFA -0.42 -9.48 -0.35 5.07e-20 Blood metabolite levels; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Total body bone mineral density; BRCA cis rs7555523 0.887 rs2790053 chr1:165737704 C/G cg24409356 chr1:165738333 TMCO1 0.51 8.29 0.31 6.9e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA trans rs11098499 0.909 rs6842762 chr4:120398236 A/T cg25214090 chr10:38739885 LOC399744 0.54 12.23 0.44 4.84e-31 Corneal astigmatism; BRCA cis rs1865760 0.602 rs9467662 chr6:26021327 G/A cg17691542 chr6:26056736 HIST1H1C 0.52 11.23 0.41 7.91e-27 Height; BRCA cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg00631329 chr6:26305371 NA -0.44 -12.83 -0.45 1.14e-33 Educational attainment; BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg11766577 chr21:47581405 C21orf56 -0.48 -10.81 -0.39 3.81e-25 Testicular germ cell tumor; BRCA cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.41e-32 Developmental language disorder (linguistic errors); BRCA trans rs62103177 0.564 rs1715230 chr18:77848002 C/T cg05926928 chr17:57297772 GDPD1 0.72 10.55 0.39 4.29e-24 Opioid sensitivity; BRCA cis rs9818758 0.607 rs34343820 chr3:49309534 C/G cg00383909 chr3:49044727 WDR6 0.76 12.57 0.45 1.6e-32 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1448094 0.512 rs60986162 chr12:86247054 T/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.83e-19 Major depressive disorder; BRCA cis rs9649465 1.000 rs6951138 chr7:123362070 G/A cg04330084 chr7:123175371 IQUB -0.33 -9.01 -0.34 2.43e-18 Migraine; BRCA cis rs3733585 0.673 rs7434391 chr4:9967682 C/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.21e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs6952808 0.692 rs11773316 chr7:2027354 C/T cg04565464 chr8:145669602 NFKBIL2 0.38 8.97 0.33 3.25e-18 Bipolar disorder and schizophrenia; BRCA cis rs7677751 0.767 rs890204 chr4:55064439 C/G cg17187183 chr4:55093834 PDGFRA 0.41 8.62 0.32 5.22e-17 Corneal astigmatism; BRCA cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg17420585 chr12:42539391 GXYLT1 -0.49 -10.61 -0.39 2.54e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg19346786 chr7:2764209 NA -0.33 -9.56 -0.35 2.58e-20 Height; BRCA cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg22307297 chr20:60903441 LAMA5 0.36 9.93 0.37 1.02e-21 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.63 -0.36 1.35e-20 Bipolar disorder and schizophrenia; BRCA cis rs9400271 0.632 rs9374070 chr6:109586455 G/A cg01475377 chr6:109611718 NA -0.43 -10.39 -0.38 1.73e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg13393036 chr8:95962371 TP53INP1 -0.34 -9.12 -0.34 9.64e-19 Type 2 diabetes; BRCA trans rs9325144 0.560 rs11183150 chr12:38674698 A/G cg23762105 chr12:34175262 ALG10 0.34 7.93 0.3 9.49e-15 Morning vs. evening chronotype; BRCA cis rs9814567 0.964 rs4539979 chr3:134287597 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.21 -0.34 4.44e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg00631329 chr6:26305371 NA -0.35 -10.07 -0.37 3e-22 Educational attainment; BRCA cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg27446573 chr6:127587934 RNF146 0.68 15.54 0.52 1.94e-46 Breast cancer; BRCA cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.22 0.41 8.85e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg01689657 chr7:91764605 CYP51A1 -0.21 -7.81 -0.3 2.4e-14 Breast cancer; BRCA cis rs250677 1.000 rs40525 chr5:148432932 G/T cg12140854 chr5:148520817 ABLIM3 0.4 8.25 0.31 9.17e-16 Breast cancer; BRCA cis rs9457247 0.765 rs10484531 chr6:167454434 G/A cg07741184 chr6:167504864 NA 0.3 8.5 0.32 1.32e-16 Crohn's disease; BRCA cis rs561341 0.941 rs8066156 chr17:30361629 A/G cg23018236 chr17:30244563 NA -0.46 -8.65 -0.32 4.07e-17 Hip circumference adjusted for BMI; BRCA cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg06238570 chr21:40685208 BRWD1 -0.39 -7.9 -0.3 1.2e-14 Menarche (age at onset); BRCA cis rs4242434 0.892 rs11776549 chr8:22493124 C/T cg03733263 chr8:22462867 KIAA1967 0.91 19.82 0.62 1.74e-68 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs9811920 0.809 rs4928235 chr3:99706870 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -13.41 -0.47 2.69e-36 Axial length; BRCA trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg14343924 chr8:8086146 FLJ10661 -0.39 -7.91 -0.3 1.16e-14 Neuroticism; BRCA cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg13628971 chr7:2884303 GNA12 0.6 13.71 0.48 1.12e-37 Height; BRCA trans rs747782 0.639 rs17198985 chr11:48183565 T/C cg15704280 chr7:45808275 SEPT13 0.58 8.44 0.32 2.16e-16 Intraocular pressure; BRCA cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.48 9.99 0.37 6.12e-22 Multiple sclerosis; BRCA cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg07395648 chr5:131743802 NA -0.36 -8.04 -0.3 4.31e-15 Breast cancer; BRCA cis rs941873 0.900 rs7092536 chr10:81131332 A/C cg11057378 chr10:81107060 PPIF 0.37 9.1 0.34 1.11e-18 Height; BRCA cis rs6430585 0.528 rs78274583 chr2:136734569 C/T cg07169764 chr2:136633963 MCM6 1.22 23.94 0.69 6.91e-91 Corneal structure; BRCA cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg24296786 chr1:45957014 TESK2 0.65 16.12 0.54 2.5e-49 High light scatter reticulocyte count; BRCA cis rs4074536 0.622 rs28849080 chr1:116319387 C/T cg21648376 chr1:116311395 CASQ2 -0.55 -9.01 -0.34 2.42e-18 QRS duration; BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg22920501 chr2:26401640 FAM59B -0.81 -13.12 -0.46 5.3e-35 Gut microbiome composition (summer); BRCA cis rs6088580 0.634 rs6088498 chr20:33020446 A/G cg24642439 chr20:33292090 TP53INP2 0.5 10.64 0.39 1.96e-24 Glomerular filtration rate (creatinine); BRCA cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg18305652 chr10:134549665 INPP5A 0.5 12.97 0.46 2.64e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg08219700 chr8:58056026 NA 0.44 8.13 0.31 2.22e-15 Developmental language disorder (linguistic errors); BRCA cis rs597539 0.652 rs579136 chr11:68637476 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.63 0.55 7.04e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs4302748 0.862 rs60346569 chr7:36184201 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs10046574 0.831 rs10250306 chr7:135165275 G/A cg27474649 chr7:135195673 CNOT4 0.51 7.97 0.3 7.4e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg13628971 chr7:2884303 GNA12 -0.59 -12.55 -0.44 1.94e-32 Height; BRCA cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg10523679 chr1:76189770 ACADM 0.91 22.19 0.66 2.64e-81 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Depression; BRCA cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg06671706 chr8:8559999 CLDN23 0.44 8.59 0.32 6.56e-17 Obesity-related traits; BRCA cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.26 0.44 3.47e-31 Lung cancer in ever smokers; BRCA cis rs17741873 0.836 rs2254266 chr10:75601688 T/C cg07699608 chr10:75541558 CHCHD1 0.53 8.49 0.32 1.4e-16 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg16606324 chr3:10149918 C3orf24 0.56 11.2 0.4 1.08e-26 Alzheimer's disease; BRCA trans rs2204008 0.774 rs12810027 chr12:38212165 A/G cg06521331 chr12:34319734 NA -0.54 -9.68 -0.36 9.28e-21 Bladder cancer; BRCA cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg04450456 chr4:17643702 FAM184B 0.39 10.86 0.39 2.38e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.52 0.57 2.09e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.51 0.41 5.68e-28 Homoarginine levels; BRCA cis rs943466 0.955 rs11757524 chr6:33766212 A/G cg25922239 chr6:33757077 LEMD2 -0.38 -7.97 -0.3 7.55e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs7582180 0.629 rs4851308 chr2:100971865 C/A cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.13e-14 Intelligence (multi-trait analysis); BRCA cis rs7523050 0.643 rs7519293 chr1:109399543 A/G cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs7582720 1.000 rs72934573 chr2:204005072 A/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.75 0.45 2.48e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs7953508 0.506 rs12425869 chr12:93961353 A/G cg18151635 chr12:93972918 NA -0.45 -9.15 -0.34 7.59e-19 Pubertal anthropometrics; BRCA cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs701145 0.938 rs189588 chr3:153995855 T/G cg17054900 chr3:154042577 DHX36 0.68 11.79 0.42 3.71e-29 Coronary artery disease; BRCA trans rs11098499 0.731 rs9995026 chr4:120490499 T/A cg25214090 chr10:38739885 LOC399744 0.52 11.52 0.41 4.81e-28 Corneal astigmatism; BRCA trans rs853679 0.882 rs9380064 chr6:28143118 A/G cg01620082 chr3:125678407 NA -0.56 -7.93 -0.3 9.71e-15 Depression; BRCA cis rs7829975 0.582 rs6983150 chr8:8792426 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -12.03 -0.43 3.29e-30 Mood instability; BRCA trans rs11098499 0.821 rs3775852 chr4:120454556 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA trans rs35110281 0.627 rs11701746 chr21:44975137 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.78 0.33 1.46e-17 Mean corpuscular volume; BRCA trans rs1200821 0.704 rs9888115 chr10:37658351 C/T cg25427524 chr10:38739819 LOC399744 0.38 8.04 0.3 4.51e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs6545883 0.868 rs2518933 chr2:61797030 C/A cg15711740 chr2:61764176 XPO1 -0.57 -14.37 -0.49 9.19e-41 Tuberculosis; BRCA cis rs11123610 0.520 rs12996655 chr2:3720900 G/A cg19052272 chr2:3704530 ALLC -0.46 -10.36 -0.38 2.32e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg01579765 chr21:45077557 HSF2BP -0.41 -10.88 -0.4 2.09e-25 Mean corpuscular volume; BRCA cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg07520158 chr7:32535189 LSM5;AVL9 0.5 11.18 0.4 1.21e-26 Cognitive ability; BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg26314531 chr2:26401878 FAM59B 0.96 16.34 0.54 2.18e-50 Gut microbiome composition (summer); BRCA cis rs2797160 0.904 rs2326292 chr6:125999674 G/A cg05901451 chr6:126070800 HEY2 -0.4 -9.48 -0.35 4.82e-20 Endometrial cancer; BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.84 13.78 0.48 5.33e-38 Platelet count; BRCA cis rs12681288 0.823 rs2701909 chr8:1003057 A/G cg04851639 chr8:1020857 NA -0.35 -10.69 -0.39 1.14e-24 Schizophrenia; BRCA cis rs6088590 0.965 rs6058108 chr20:33288655 A/G cg24642439 chr20:33292090 TP53INP2 0.64 14.58 0.5 8.83e-42 Coronary artery disease; BRCA trans rs17685 0.884 rs6978677 chr7:75636240 C/T cg19862616 chr7:65841803 NCRNA00174 0.65 17.57 0.57 1.18e-56 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4319547 0.695 rs11058034 chr12:122894936 G/T cg23029597 chr12:123009494 RSRC2 0.65 11.53 0.41 4.49e-28 Body mass index; BRCA cis rs11168351 0.517 rs10875754 chr12:48557922 G/C cg24011408 chr12:48396354 COL2A1 0.44 9.77 0.36 4.3e-21 Bipolar disorder and schizophrenia; BRCA cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.41 11.53 0.42 4.3e-28 Monocyte percentage of white cells; BRCA cis rs10779751 0.770 rs12097293 chr1:11197467 A/G cg08854313 chr1:11322531 MTOR -0.71 -14.14 -0.49 1.05e-39 Body mass index; BRCA cis rs1595825 0.838 rs73056856 chr2:198801209 C/G cg19156104 chr2:198669113 PLCL1 -0.45 -8.26 -0.31 8.46e-16 Ulcerative colitis; BRCA cis rs2108225 0.872 rs6980029 chr7:107446127 T/C cg18560240 chr7:107437656 SLC26A3 -0.54 -11.29 -0.41 4.55e-27 Ulcerative colitis; BRCA cis rs760805 0.965 rs11249203 chr1:25258585 G/C cg22509179 chr1:25234806 RUNX3 -0.57 -14.56 -0.5 1.12e-41 Allergic disease (asthma, hay fever or eczema); BRCA trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21659725 chr3:3221576 CRBN -0.7 -20.95 -0.64 1.37e-74 Intelligence (multi-trait analysis); BRCA cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg01849466 chr14:104193079 ZFYVE21 -0.45 -10.2 -0.37 9.65e-23 Reticulocyte count; BRCA trans rs7647973 0.626 rs62260723 chr3:49872124 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.39 8.02 0.3 5.14e-15 Menarche (age at onset); BRCA cis rs6088813 1.000 rs725908 chr20:33968067 T/C cg14752227 chr20:34000481 UQCC -0.39 -7.97 -0.3 7.46e-15 Height; BRCA cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.4 8.3 0.31 6.39e-16 Aortic root size; BRCA trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg13010199 chr12:38710504 ALG10B -0.43 -9.14 -0.34 8.07e-19 Morning vs. evening chronotype; BRCA cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg22117172 chr7:91764530 CYP51A1 0.23 7.87 0.3 1.52e-14 Breast cancer; BRCA cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg12310025 chr6:25882481 NA -0.51 -11.14 -0.4 1.8e-26 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.95e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs2749592 0.531 rs1208559 chr10:38221370 T/C cg17830980 chr10:43048298 ZNF37B 0.4 8.52 0.32 1.18e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6901250 0.851 rs339324 chr6:117195024 C/T cg12892004 chr6:117198278 RFX6 -0.48 -11.03 -0.4 5.35e-26 C-reactive protein levels; BRCA cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg03709012 chr19:19516395 GATAD2A -0.8 -18.59 -0.59 5.39e-62 Tonsillectomy; BRCA cis rs4930561 0.714 rs11228151 chr11:67949371 C/G cg04465784 chr11:67976953 SUV420H1 -0.26 -8.57 -0.32 8.05e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs1801251 1.000 rs11676216 chr2:233706368 C/T cg08000102 chr2:233561755 GIGYF2 -0.63 -13.61 -0.47 3.18e-37 Coronary artery disease; BRCA cis rs17601876 0.814 rs17523527 chr15:51554032 C/T cg19946085 chr15:51559439 CYP19A1 -0.36 -9.91 -0.37 1.2e-21 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1691799 0.899 rs1185244 chr12:66725160 C/T cg16791601 chr12:66731901 HELB -0.64 -17.25 -0.56 5.11e-55 White blood cell count (basophil); BRCA cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg17892150 chr10:133769511 PPP2R2D -0.73 -15.66 -0.53 4.96e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9291683 0.526 rs7695555 chr4:10001656 T/C cg11266682 chr4:10021025 SLC2A9 0.39 10.36 0.38 2.41e-23 Bone mineral density; BRCA cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg18876405 chr7:65276391 NA -0.51 -11.59 -0.42 2.49e-28 Aortic root size; BRCA cis rs61931739 0.534 rs1586410 chr12:33999142 C/T cg06521331 chr12:34319734 NA -0.62 -11.13 -0.4 2.05e-26 Morning vs. evening chronotype; BRCA cis rs939658 0.728 rs11637459 chr15:79413554 A/G cg17916960 chr15:79447300 NA -0.44 -10.54 -0.38 4.78e-24 Refractive error; BRCA cis rs9649465 1.000 rs11765478 chr7:123362872 A/C cg04330084 chr7:123175371 IQUB -0.31 -8.44 -0.32 2.13e-16 Migraine; BRCA cis rs10751667 0.643 rs10902237 chr11:944801 C/A ch.11.42038R chr11:967971 AP2A2 0.5 15.52 0.52 2.53e-46 Alzheimer's disease (late onset); BRCA cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.28 -0.44 2.87e-31 Personality dimensions; BRCA cis rs4074536 0.536 rs12737145 chr1:116284602 G/A cg21648376 chr1:116311395 CASQ2 -0.48 -8.23 -0.31 1.02e-15 QRS duration; BRCA cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg13010199 chr12:38710504 ALG10B 0.51 9.8 0.36 3.24e-21 Bladder cancer; BRCA cis rs2797160 1.000 rs2797158 chr6:126009398 G/A cg05901451 chr6:126070800 HEY2 0.4 9.69 0.36 8.04e-21 Endometrial cancer; BRCA cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg26384229 chr12:38710491 ALG10B 0.72 17.02 0.56 7.11e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs9682041 0.597 rs62295834 chr3:170075701 G/A cg11886554 chr3:170076028 SKIL 0.51 10.21 0.37 9.31e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs55894533 0.597 rs2645408 chr8:11746358 A/G cg21281001 chr8:11725306 CTSB 0.54 11.47 0.41 8.09e-28 Leprosy; BRCA cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg00745463 chr17:30367425 LRRC37B -0.6 -9.77 -0.36 4.04e-21 Hip circumference adjusted for BMI; BRCA cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg20503657 chr10:835505 NA 0.92 15.45 0.52 5.23e-46 Eosinophil percentage of granulocytes; BRCA cis rs589448 0.902 rs642786 chr12:69758462 T/C cg22834771 chr12:69754056 YEATS4 -0.42 -10.56 -0.39 3.79e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs12155623 0.619 rs870397 chr8:49861225 C/T cg00325661 chr8:49890786 NA 0.33 8.81 0.33 1.19e-17 Sudden cardiac arrest; BRCA cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg11742103 chr11:62369870 EML3;MTA2 0.35 9.01 0.34 2.32e-18 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg22920501 chr2:26401640 FAM59B 0.89 16.09 0.54 3.71e-49 Gut microbiome composition (summer); BRCA cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.55 14.22 0.49 4.76e-40 Colorectal cancer; BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg17158414 chr2:27665306 KRTCAP3 -0.34 -8.96 -0.33 3.48e-18 Total body bone mineral density; BRCA cis rs3771570 1.000 rs3771570 chr2:242382864 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.33 0.35 1.79e-19 Prostate cancer; BRCA cis rs7617773 0.780 rs7653152 chr3:48362097 G/C cg11946769 chr3:48343235 NME6 0.69 13.74 0.48 8.05e-38 Coronary artery disease; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg15112475 chr7:1198522 ZFAND2A -0.41 -9.28 -0.34 2.59e-19 Longevity;Endometriosis; BRCA cis rs62005083 0.541 rs61059815 chr14:74536465 A/T cg05179529 chr14:74551516 LIN52;ALDH6A1 0.52 7.92 0.3 1.03e-14 Mean corpuscular volume; BRCA cis rs9815354 0.812 rs73073234 chr3:42012071 C/T cg03022575 chr3:42003672 ULK4 0.73 10.09 0.37 2.52e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg23711669 chr6:146136114 FBXO30 0.73 17.14 0.56 1.74e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg02353165 chr6:42928485 GNMT 0.89 24.06 0.69 1.41e-91 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs17270561 0.609 rs4711101 chr6:25741970 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs1008375 0.932 rs6835077 chr4:17653285 A/T cg04450456 chr4:17643702 FAM184B 0.36 9.85 0.36 2.08e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg08917208 chr2:24149416 ATAD2B 0.58 9.19 0.34 5.5e-19 Lymphocyte counts; BRCA cis rs4285028 0.948 rs34181646 chr3:121705373 T/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.84 -0.39 3.02e-25 Multiple sclerosis; BRCA cis rs250677 1.000 rs36082 chr5:148428844 C/G cg25326776 chr5:148520934 ABLIM3 -0.42 -7.96 -0.3 8.11e-15 Breast cancer; BRCA cis rs2404602 0.647 rs4312276 chr15:77164361 T/C cg23625390 chr15:77176239 SCAPER -0.55 -13.02 -0.46 1.53e-34 Blood metabolite levels; BRCA cis rs17270561 0.666 rs1141034 chr6:25780332 C/T cg17691542 chr6:26056736 HIST1H1C 0.54 10.72 0.39 9.22e-25 Iron status biomarkers; BRCA cis rs10504073 0.647 rs10808744 chr8:49988984 A/G cg00325661 chr8:49890786 NA 0.44 12.49 0.44 3.46e-32 Blood metabolite ratios; BRCA cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24110177 chr3:50126178 RBM5 0.36 9.65 0.36 1.19e-20 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11890956 chr21:40555474 PSMG1 -0.62 -13.82 -0.48 3.3e-38 Menarche (age at onset); BRCA cis rs9381040 0.610 rs9357345 chr6:41025118 G/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.06 -0.34 1.55e-18 Alzheimer's disease (late onset); BRCA cis rs754466 0.580 rs12354903 chr10:79536465 T/C cg17075019 chr10:79541650 NA -0.87 -23.88 -0.69 1.36e-90 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg19346786 chr7:2764209 NA -0.39 -11.16 -0.4 1.53e-26 Height; BRCA cis rs11105298 0.891 rs3741898 chr12:89933763 G/C cg00757033 chr12:89920650 WDR51B 0.52 10.52 0.38 5.8e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7267979 1.000 rs2482928 chr20:25331530 A/G cg08601574 chr20:25228251 PYGB -0.38 -9.07 -0.34 1.41e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7481584 0.624 rs375579 chr11:3065300 G/C cg08508325 chr11:3079039 CARS 0.28 8.48 0.32 1.56e-16 Calcium levels; BRCA cis rs2839186 0.868 rs2839199 chr21:47708269 T/C cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg11301795 chr4:187892539 NA -0.31 -10.2 -0.37 1.01e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg00071950 chr4:10020882 SLC2A9 0.64 16.0 0.53 1.06e-48 Bone mineral density; BRCA cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg11266682 chr4:10021025 SLC2A9 -0.41 -10.82 -0.39 3.44e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3767633 0.528 rs6671373 chr1:161890796 C/G cg27519958 chr1:161735129 ATF6 -0.49 -11.73 -0.42 6.39e-29 IgG glycosylation; BRCA cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.68e-16 Putamen volume; BRCA cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.46e-15 Extrinsic epigenetic age acceleration; BRCA cis rs11945232 1.000 rs28406846 chr4:88343468 C/G cg23841344 chr4:88312519 HSD17B11 -0.49 -9.57 -0.35 2.29e-20 Intelligence (multi-trait analysis); BRCA cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg12365402 chr11:9010492 NRIP3 0.45 9.93 0.37 1.07e-21 Hemoglobin concentration; BRCA cis rs427394 0.664 rs274701 chr5:6728707 C/A cg10857441 chr5:6722123 POLS -0.32 -10.9 -0.4 1.66e-25 Menopause (age at onset); BRCA trans rs9929218 0.551 rs7201437 chr16:68727130 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 1.01 30.72 0.77 5.71e-128 Colorectal cancer; BRCA cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg20891283 chr12:69753455 YEATS4 0.7 18.91 0.6 1.18e-63 Blood protein levels; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.02 18.02 0.58 5.32e-59 Gut microbiome composition (summer); BRCA cis rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05901451 chr6:126070800 HEY2 0.4 9.7 0.36 7.73e-21 Endometrial cancer; BRCA cis rs7666738 0.830 rs10009206 chr4:99056900 A/C cg05340658 chr4:99064831 C4orf37 -0.5 -11.74 -0.42 5.85e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg24642439 chr20:33292090 TP53INP2 0.69 15.47 0.52 4.16e-46 Coronary artery disease; BRCA cis rs911555 0.723 rs7144010 chr14:103869869 G/A cg12935359 chr14:103987150 CKB 0.62 14.54 0.5 1.45e-41 Intelligence (multi-trait analysis); BRCA cis rs9427116 0.502 rs9426827 chr1:154589965 T/C cg17218026 chr1:154582156 ADAR 0.28 8.38 0.31 3.46e-16 Blood protein levels; BRCA cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2688608 0.592 rs10762559 chr10:75486453 G/C cg23231163 chr10:75533350 FUT11 -0.34 -8.89 -0.33 6e-18 Inflammatory bowel disease; BRCA cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg13319975 chr6:146136371 FBXO30 0.36 8.46 0.32 1.85e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11971779 0.680 rs6954531 chr7:139054706 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.6 0.39 2.61e-24 Cognitive ability; BRCA cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg03146154 chr1:46216737 IPP -0.45 -10.04 -0.37 3.89e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7617773 0.539 rs12486935 chr3:48390164 C/T cg11946769 chr3:48343235 NME6 0.45 9.48 0.35 4.8e-20 Coronary artery disease; BRCA cis rs10465746 0.780 rs1871924 chr1:84398466 T/A cg10977910 chr1:84465055 TTLL7 0.56 11.63 0.42 1.77e-28 Obesity-related traits; BRCA trans rs853679 0.882 rs4713139 chr6:28092685 C/T cg01620082 chr3:125678407 NA -0.57 -8.08 -0.3 3.19e-15 Depression; BRCA cis rs2991971 1.000 rs2991972 chr1:46013208 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC -0.34 -7.82 -0.3 2.26e-14 High light scatter reticulocyte count; BRCA cis rs9287719 0.967 rs7587231 chr2:10740093 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg21475434 chr5:93447410 FAM172A 0.65 8.65 0.32 4e-17 Diabetic retinopathy; BRCA trans rs7939886 0.920 rs61742348 chr11:55905078 C/T cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.9 0.3 1.21e-14 Tonsillectomy; BRCA cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12310956 0.532 rs11052954 chr12:33993512 C/G cg06521331 chr12:34319734 NA -0.57 -11.06 -0.4 4e-26 Morning vs. evening chronotype; BRCA cis rs6570726 0.764 rs4263604 chr6:145916697 A/G cg13319975 chr6:146136371 FBXO30 -0.36 -8.34 -0.31 4.63e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs60843830 0.596 rs17041320 chr2:112051 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.45 8.63 0.32 4.92e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6815814 0.950 rs73236633 chr4:38839319 T/C cg02016764 chr4:38805732 TLR1 -0.52 -7.83 -0.3 2e-14 Breast cancer; BRCA cis rs6542838 0.704 rs12474283 chr2:99527310 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -9.6 -0.35 1.81e-20 Fear of minor pain; BRCA cis rs877282 0.945 rs10904550 chr10:774177 C/T cg17470449 chr10:769945 NA 0.5 9.49 0.35 4.33e-20 Uric acid levels; BRCA cis rs36051895 0.632 rs7871515 chr9:5175288 A/G cg02405213 chr9:5042618 JAK2 0.44 8.57 0.32 7.91e-17 Pediatric autoimmune diseases; BRCA cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg01689657 chr7:91764605 CYP51A1 0.22 8.13 0.31 2.24e-15 Breast cancer; BRCA cis rs75804782 0.641 rs72987304 chr2:239345532 C/T cg18131467 chr2:239335373 ASB1 -0.62 -7.98 -0.3 6.89e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23221052 chr5:179740743 GFPT2 0.64 13.55 0.47 5.94e-37 Height; BRCA cis rs2204008 0.775 rs11182513 chr12:38560252 G/C cg26384229 chr12:38710491 ALG10B 0.78 18.11 0.58 1.71e-59 Bladder cancer; BRCA cis rs4557202 0.509 rs12690576 chr3:160647912 G/A cg03342759 chr3:160939853 NMD3 -0.53 -11.05 -0.4 4.35e-26 Menarche (age at onset); BRCA cis rs73001065 0.818 rs73004966 chr19:19716558 C/T cg03709012 chr19:19516395 GATAD2A 0.76 9.65 0.36 1.16e-20 LDL cholesterol; BRCA cis rs17376456 0.778 rs10440717 chr5:93424852 C/A cg25358565 chr5:93447407 FAM172A 1.2 19.94 0.62 3.82e-69 Diabetic retinopathy; BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24549020 chr5:56110836 MAP3K1 0.64 12.81 0.45 1.29e-33 Initial pursuit acceleration; BRCA cis rs7662987 0.517 rs2924580 chr4:100032168 C/G cg12011299 chr4:100065546 ADH4 0.49 11.06 0.4 3.83e-26 Smoking initiation; BRCA cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg08859206 chr1:53392774 SCP2 0.41 8.17 0.31 1.66e-15 Monocyte count; BRCA trans rs1005277 0.579 rs1780133 chr10:38499509 T/C cg23533926 chr12:111358616 MYL2 -0.43 -9.14 -0.34 8.32e-19 Extrinsic epigenetic age acceleration; BRCA cis rs78456975 1.000 rs13413356 chr2:1553849 G/T cg26248373 chr2:1572462 NA -0.47 -9.29 -0.35 2.34e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs701145 0.556 rs355763 chr3:154012881 C/T cg16511985 chr3:153974050 SGEF 0.46 10.55 0.39 4.19e-24 Coronary artery disease; BRCA cis rs698833 0.532 rs2616444 chr2:44605518 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.93 0.37 1.02e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.75e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs921968 0.509 rs7571743 chr2:219352572 C/T cg10223061 chr2:219282414 VIL1 -0.27 -7.94 -0.3 8.88e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs6582630 0.555 rs2004152 chr12:38478951 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.28 0.38 4.77e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs724568 0.546 rs1367457 chr2:67951861 C/T cg17945962 chr2:67939740 NA 0.38 9.96 0.37 7.95e-22 Major depressive disorder (broad); BRCA cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg18876405 chr7:65276391 NA -0.54 -12.69 -0.45 4.52e-33 Aortic root size; BRCA cis rs950776 0.518 rs952215 chr15:78819153 C/T cg22563815 chr15:78856949 CHRNA5 -0.35 -8.1 -0.31 2.86e-15 Sudden cardiac arrest; BRCA cis rs1865760 0.551 rs9461230 chr6:26019240 G/C cg16482183 chr6:26056742 HIST1H1C 0.51 10.95 0.4 1.11e-25 Height; BRCA cis rs9399135 0.660 rs4267967 chr6:135272477 T/G cg24558204 chr6:135376177 HBS1L 0.48 13.36 0.47 4.64e-36 Red blood cell count; BRCA cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg04455712 chr21:45112962 RRP1B 0.48 13.11 0.46 6.17e-35 Mean corpuscular volume; BRCA cis rs12618769 0.543 rs72819980 chr2:99040522 A/G cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.62e-15 Bipolar disorder; BRCA cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg11764359 chr7:65958608 NA 0.65 11.9 0.43 1.21e-29 Aortic root size; BRCA trans rs9291683 0.509 rs998676 chr4:9948564 T/C cg26043149 chr18:55253948 FECH -0.4 -9.1 -0.34 1.11e-18 Bone mineral density; BRCA cis rs6088580 0.634 rs62212172 chr20:32987705 G/A cg08999081 chr20:33150536 PIGU -0.44 -12.28 -0.44 2.85e-31 Glomerular filtration rate (creatinine); BRCA cis rs9486719 1.000 rs4077932 chr6:96905144 C/T cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.66e-34 Migraine;Coronary artery disease; BRCA cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg02079420 chr8:82753780 SNX16 0.31 8.43 0.32 2.27e-16 Diastolic blood pressure; BRCA cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.37 -0.35 1.2e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg24060327 chr5:131705240 SLC22A5 0.51 10.7 0.39 1.05e-24 Blood metabolite levels; BRCA cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg09184832 chr6:79620586 NA -0.46 -10.02 -0.37 4.81e-22 Intelligence (multi-trait analysis); BRCA cis rs9868809 0.505 rs9877685 chr3:48748588 C/T cg00383909 chr3:49044727 WDR6 0.6 10.99 0.4 7.23e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs6594499 1.000 rs1438673 chr5:110467499 C/T cg04022379 chr5:110408740 TSLP 0.37 8.04 0.3 4.52e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7903847 0.596 rs10786340 chr10:99156563 G/C cg20016023 chr10:99160130 RRP12 -0.26 -8.47 -0.32 1.68e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs4363385 0.818 rs378010 chr1:153007987 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.5 -0.32 1.38e-16 Inflammatory skin disease; BRCA trans rs7824557 0.614 rs2736286 chr8:11227104 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -8.7 -0.33 2.89e-17 Retinal vascular caliber; BRCA cis rs4853036 0.586 rs35286755 chr2:70005173 T/G cg02498382 chr2:70120550 SNRNP27 -0.49 -7.99 -0.3 6.39e-15 Colorectal or endometrial cancer; BRCA cis rs4812048 0.793 rs62205397 chr20:57597011 C/T cg14073986 chr20:57617431 SLMO2 0.56 8.5 0.32 1.3e-16 Mean platelet volume; BRCA cis rs3820928 0.605 rs10186145 chr2:227781150 A/G cg11843606 chr2:227700838 RHBDD1 -0.51 -11.69 -0.42 9.33e-29 Pulmonary function; BRCA cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg12463550 chr7:65579703 CRCP 0.36 8.01 0.3 5.52e-15 Aortic root size; BRCA cis rs965469 0.895 rs6139123 chr20:3396634 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.6 -0.39 2.73e-24 IFN-related cytopenia; BRCA cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg18876405 chr7:65276391 NA -0.6 -15.01 -0.51 7.84e-44 Aortic root size; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg04944784 chr2:26401820 FAM59B -0.85 -13.27 -0.46 1.19e-35 Gut microbiome composition (summer); BRCA cis rs4363385 0.747 rs3753454 chr1:152973776 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.09 -0.34 1.22e-18 Inflammatory skin disease; BRCA cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.83 0.39 3.27e-25 Bipolar disorder; BRCA cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg08213375 chr14:104286397 PPP1R13B 0.4 8.59 0.32 6.75e-17 Reticulocyte count; BRCA cis rs708547 0.581 rs10020462 chr4:57825593 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.36 -8.97 -0.33 3.31e-18 Response to bleomycin (chromatid breaks); BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18301423 chr5:131593218 PDLIM4 0.34 8.66 0.32 3.71e-17 Breast cancer; BRCA cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg12927641 chr6:109611667 NA -0.42 -10.99 -0.4 7.54e-26 Reticulocyte fraction of red cells; BRCA cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.87 0.3 1.56e-14 Depression; BRCA cis rs561341 1.000 rs2344312 chr17:30243583 G/T cg13647721 chr17:30228624 UTP6 0.5 9.02 0.34 2.15e-18 Hip circumference adjusted for BMI; BRCA cis rs9517320 0.534 rs912330 chr13:99131294 C/T cg20487152 chr13:99095054 FARP1 -0.34 -7.84 -0.3 1.93e-14 Longevity; BRCA trans rs11976180 0.517 rs6949375 chr7:143773851 T/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.94 -14.33 -0.49 1.37e-40 Obesity-related traits; BRCA cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg15395560 chr15:45543142 SLC28A2 -0.29 -7.83 -0.3 2.02e-14 Uric acid levels; BRCA cis rs7833986 1.000 rs66796428 chr8:57094797 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.27 0.31 7.62e-16 Height; BRCA cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg08219700 chr8:58056026 NA 0.44 8.01 0.3 5.57e-15 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.866 rs9995136 chr4:120286845 A/G cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA trans rs17685 0.753 rs8200 chr7:75696606 C/G cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.72 -0.74 1.12e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7520050 0.966 rs12021587 chr1:46472759 G/T cg24296786 chr1:45957014 TESK2 0.44 9.84 0.36 2.33e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg00409905 chr10:38381863 ZNF37A 0.45 9.38 0.35 1.12e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs11098499 0.863 rs9884402 chr4:120489982 A/G cg09307838 chr4:120376055 NA 0.68 14.12 0.49 1.28e-39 Corneal astigmatism; BRCA cis rs2712184 0.756 rs2024489 chr2:217661530 A/G cg05032264 chr2:217675019 NA -0.36 -8.69 -0.33 3e-17 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.41 -0.44 7.98e-32 Bipolar disorder; BRCA cis rs8114671 0.562 rs8116657 chr20:33476474 C/G cg24642439 chr20:33292090 TP53INP2 0.41 8.0 0.3 5.83e-15 Height; BRCA cis rs7647973 0.710 rs12637313 chr3:49645458 A/G cg07636037 chr3:49044803 WDR6 0.55 8.74 0.33 2.09e-17 Menarche (age at onset); BRCA cis rs6598955 0.617 rs11247895 chr1:26599542 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs7103648 0.695 rs10838726 chr11:47568344 C/G cg03711944 chr11:47377212 SPI1 -0.41 -9.75 -0.36 5.1e-21 Diastolic blood pressure;Systolic blood pressure; BRCA trans rs61931739 0.517 rs1197562 chr12:34122037 G/A cg26384229 chr12:38710491 ALG10B 0.54 11.92 0.43 1e-29 Morning vs. evening chronotype; BRCA cis rs7607369 0.791 rs72965151 chr2:219344165 G/T cg10223061 chr2:219282414 VIL1 0.29 8.15 0.31 1.92e-15 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.67 11.79 0.42 3.66e-29 Lung cancer in ever smokers; BRCA cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg11890956 chr21:40555474 PSMG1 1.02 27.95 0.74 6.78e-113 Cognitive function; BRCA cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg23711669 chr6:146136114 FBXO30 0.72 14.36 0.49 9.97e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs7917772 0.560 rs3862030 chr10:104327584 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs3796619 1.000 rs11939380 chr4:1086871 C/T cg27284194 chr4:1044797 NA -0.41 -8.98 -0.33 2.9e-18 Recombination rate (males); BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.04 0.34 1.81e-18 Tonsillectomy; BRCA trans rs61931739 0.500 rs7311302 chr12:34557211 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.62 0.47 2.98e-37 Morning vs. evening chronotype; BRCA cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg00990874 chr7:1149470 C7orf50 -0.56 -10.62 -0.39 2.19e-24 Bronchopulmonary dysplasia; BRCA cis rs1011018 0.628 rs12374779 chr7:139453505 T/C cg03224163 chr7:139420300 HIPK2 -0.59 -8.97 -0.33 3.35e-18 Systolic blood pressure; BRCA cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg17420585 chr12:42539391 GXYLT1 -0.48 -10.4 -0.38 1.66e-23 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7715811 1.000 rs6554813 chr5:13763039 G/A cg07548982 chr5:13769939 DNAH5 -0.38 -8.3 -0.31 6.2e-16 Subclinical atherosclerosis traits (other); BRCA cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg25801113 chr15:45476975 SHF -0.33 -8.3 -0.31 6.21e-16 Uric acid levels; BRCA cis rs534126 0.744 rs10248147 chr7:142941023 C/G cg15652212 chr7:142981776 TMEM139 -0.46 -10.34 -0.38 2.84e-23 Cancer; BRCA cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.2 -0.41 1.02e-26 Schizophrenia; BRCA cis rs11971779 0.680 rs2355785 chr7:139070983 C/A cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs7267979 1.000 rs448396 chr20:25440269 G/A cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2901460 0.509 rs12470090 chr2:62094367 T/C cg02183531 chr2:62113199 CCT4 -0.45 -8.83 -0.33 9.75e-18 Mean corpuscular volume; BRCA cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.37 -0.31 3.62e-16 Total body bone mineral density; BRCA cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.17 0.31 1.64e-15 Parkinson's disease; BRCA trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg10896456 chr17:42255109 ASB16;C17orf65 -0.33 -7.85 -0.3 1.77e-14 Total body bone mineral density; BRCA cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg15017067 chr4:17643749 FAM184B 0.26 7.98 0.3 6.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2742417 0.624 rs2673029 chr3:45758867 A/G cg04837898 chr3:45731254 SACM1L -0.4 -8.11 -0.31 2.59e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs3796352 0.571 rs71301816 chr3:53142071 G/A cg07884673 chr3:53033167 SFMBT1 0.7 8.55 0.32 9.23e-17 Immune reponse to smallpox (secreted IL-2); BRCA cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg11764359 chr7:65958608 NA -0.75 -16.8 -0.55 9.56e-53 Aortic root size; BRCA cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg04450456 chr4:17643702 FAM184B 0.35 10.14 0.37 1.66e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg00074818 chr8:8560427 CLDN23 0.38 8.35 0.31 4.17e-16 Obesity-related traits; BRCA cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg08493051 chr2:3487164 NA -0.43 -9.19 -0.34 5.56e-19 Neurofibrillary tangles; BRCA cis rs9399135 0.935 rs11754504 chr6:135321509 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.42 0.44 7.31e-32 Red blood cell count; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg00814883 chr7:100076585 TSC22D4 -0.49 -9.97 -0.37 7.61e-22 Platelet count; BRCA cis rs835154 0.845 rs835156 chr5:14875813 C/A cg18064842 chr5:14874549 NA -0.48 -13.04 -0.46 1.31e-34 Blood metabolite levels; BRCA cis rs9287719 0.904 rs55738250 chr2:10757132 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.16 -0.31 1.79e-15 Prostate cancer; BRCA cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg20503657 chr10:835505 NA 0.88 16.0 0.53 1.02e-48 Eosinophil percentage of granulocytes; BRCA cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg04450456 chr4:17643702 FAM184B -0.36 -10.24 -0.38 7.07e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg14547644 chr6:28411285 ZSCAN23 -0.35 -7.91 -0.3 1.17e-14 Pubertal anthropometrics; BRCA cis rs1003719 0.591 rs2835633 chr21:38525019 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.57 -13.2 -0.46 2.26e-35 Eye color traits; BRCA trans rs60843830 1.000 rs55936726 chr2:258210 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.83 0.51 5.64e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.62 10.61 0.39 2.37e-24 Lung function (FEV1/FVC); BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 16.71 0.55 2.98e-52 Alzheimer's disease; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.39 0.35 1.01e-19 Tonsillectomy; BRCA cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg04455712 chr21:45112962 RRP1B 0.41 10.7 0.39 1.07e-24 Mean corpuscular volume; BRCA cis rs7607369 0.536 rs12990447 chr2:219667413 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -10.13 -0.37 1.75e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs2625529 0.878 rs71395051 chr15:72239789 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.27 -0.56 3.79e-55 Red blood cell count; BRCA cis rs10181042 0.514 rs1177289 chr2:61353256 T/C cg15711740 chr2:61764176 XPO1 -0.37 -8.76 -0.33 1.8e-17 Crohn's disease; BRCA cis rs317689 0.513 rs317678 chr12:69692166 C/G cg20891283 chr12:69753455 YEATS4 0.47 10.92 0.4 1.39e-25 Response to diuretic therapy; BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.54 0.38 4.75e-24 Tonsillectomy; BRCA cis rs9807989 0.507 rs6543133 chr2:103040177 A/T cg03938978 chr2:103052716 IL18RAP 0.29 8.3 0.31 6.11e-16 Asthma; BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg26119090 chr2:26468346 HADHA;HADHB 0.75 11.64 0.42 1.51e-28 Gut microbiome composition (summer); BRCA cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg00031303 chr3:195681400 NA 0.45 8.57 0.32 7.88e-17 Pancreatic cancer; BRCA cis rs826838 0.616 rs2387921 chr12:38624767 T/C cg26384229 chr12:38710491 ALG10B -0.44 -10.14 -0.37 1.63e-22 Heart rate; BRCA cis rs9837602 0.938 rs9814359 chr3:99797013 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 10.36 0.38 2.3e-23 Breast cancer; BRCA cis rs7560272 0.538 rs2421575 chr2:73919522 G/A cg20560298 chr2:73613845 ALMS1 0.36 9.26 0.34 3.06e-19 Schizophrenia; BRCA cis rs7903847 0.642 rs7092499 chr10:99140313 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.34 -0.31 4.57e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs4481887 0.861 rs6681336 chr1:248482756 C/T cg13385794 chr1:248469461 NA 0.28 8.11 0.31 2.62e-15 Common traits (Other); BRCA cis rs3947 0.906 rs709822 chr8:11702313 C/G cg00262122 chr8:11665843 FDFT1 -0.43 -8.39 -0.32 3.1e-16 Blood protein levels; BRCA cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg24642439 chr20:33292090 TP53INP2 0.69 15.69 0.53 3.65e-47 Coronary artery disease; BRCA cis rs2243480 1.000 rs4718334 chr7:65789454 G/A cg18252515 chr7:66147081 NA 1.01 15.2 0.52 9.4e-45 Diabetic kidney disease; BRCA cis rs477692 0.699 rs528549 chr10:131381574 A/G cg05714579 chr10:131428358 MGMT 0.5 11.21 0.41 9.49e-27 Response to temozolomide; BRCA cis rs36051895 0.589 rs6476948 chr9:5204404 C/T cg02405213 chr9:5042618 JAK2 -0.44 -8.33 -0.31 4.81e-16 Pediatric autoimmune diseases; BRCA cis rs7208859 0.623 rs73269923 chr17:29102571 C/T cg13385521 chr17:29058706 SUZ12P 0.74 10.5 0.38 6.75e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs350251 0.899 rs350277 chr16:12232547 C/T cg06014057 chr16:12226852 SNX29 0.29 7.97 0.3 7.57e-15 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg21724239 chr8:58056113 NA 0.58 9.44 0.35 7.02e-20 Developmental language disorder (linguistic errors); BRCA cis rs453301 0.658 rs9329175 chr8:8866661 C/T cg15556689 chr8:8085844 FLJ10661 -0.33 -8.88 -0.33 6.75e-18 Joint mobility (Beighton score); BRCA cis rs11971779 0.680 rs73154134 chr7:139039951 G/A cg07862535 chr7:139043722 LUC7L2 0.39 10.33 0.38 3.14e-23 Diisocyanate-induced asthma; BRCA cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg09184832 chr6:79620586 NA -0.48 -10.4 -0.38 1.69e-23 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.869 rs2777473 chr6:146301494 G/A cg23711669 chr6:146136114 FBXO30 0.64 14.49 0.5 2.31e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs6500602 0.789 rs2404546 chr16:4479734 C/G cg08645402 chr16:4508243 NA 0.34 8.26 0.31 8.63e-16 Schizophrenia; BRCA cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.36 -0.41 2.32e-27 Schizophrenia; BRCA cis rs7523273 0.606 rs2796271 chr1:207941927 A/G cg22525895 chr1:207977042 MIR29B2 0.47 12.01 0.43 4.14e-30 Schizophrenia; BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg04727924 chr7:799746 HEATR2 -0.52 -9.07 -0.34 1.47e-18 Cerebrospinal P-tau181p levels; BRCA trans rs11764590 0.694 rs55860148 chr7:2105594 G/A cg11693508 chr17:37793320 STARD3 0.52 10.45 0.38 1.09e-23 Neuroticism; BRCA cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg18446336 chr7:2847575 GNA12 -0.34 -8.2 -0.31 1.36e-15 Height; BRCA cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg24130564 chr14:104152367 KLC1 0.36 8.04 0.3 4.42e-15 Intelligence (multi-trait analysis); BRCA cis rs7737355 0.947 rs58991576 chr5:130589540 T/C cg06307176 chr5:131281290 NA -0.43 -8.48 -0.32 1.54e-16 Life satisfaction; BRCA cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg24558204 chr6:135376177 HBS1L 0.6 16.25 0.54 5.98e-50 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs17376456 0.877 rs28637444 chr5:93495548 C/T cg25358565 chr5:93447407 FAM172A 1.25 19.16 0.6 5.42e-65 Diabetic retinopathy; BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg08470875 chr2:26401718 FAM59B 0.68 10.26 0.38 5.63e-23 Gut microbiome composition (summer); BRCA cis rs6424115 0.557 rs35904775 chr1:24180623 T/C cg15997130 chr1:24165203 NA -0.51 -13.39 -0.47 3.11e-36 Immature fraction of reticulocytes; BRCA cis rs6460942 0.915 rs62447639 chr7:12486803 T/C cg20607287 chr7:12443886 VWDE -0.58 -8.24 -0.31 9.69e-16 Coronary artery disease; BRCA cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg14004847 chr7:1930337 MAD1L1 -0.41 -8.26 -0.31 8.16e-16 Bipolar disorder and schizophrenia; BRCA cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg12311346 chr5:56204834 C5orf35 0.61 12.59 0.45 1.29e-32 Initial pursuit acceleration; BRCA cis rs733592 1.000 rs733592 chr12:48429776 C/T cg24011408 chr12:48396354 COL2A1 -0.44 -9.43 -0.35 7.26e-20 Plateletcrit; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg14863265 chr7:2801509 GNA12 -0.47 -10.22 -0.37 8.53e-23 Height; BRCA cis rs250677 0.958 rs36067 chr5:148417553 T/G cg18129178 chr5:148520854 ABLIM3 -0.59 -11.98 -0.43 5.71e-30 Breast cancer; BRCA cis rs9649465 0.967 rs7791183 chr7:123343719 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.32 -0.31 5.51e-16 Migraine; BRCA trans rs57221529 0.766 rs12522140 chr5:587261 C/A cg11887960 chr12:57824829 NA 0.53 8.26 0.31 8.2e-16 Lung disease severity in cystic fibrosis; BRCA cis rs1949733 0.701 rs871768 chr4:8454938 G/A cg13073564 chr4:8508604 NA -0.39 -10.61 -0.39 2.43e-24 Response to antineoplastic agents; BRCA cis rs9399135 0.967 rs9389251 chr6:135325717 A/G cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 8.89e-33 Red blood cell count; BRCA cis rs877282 1.000 rs11253366 chr10:773386 C/T cg17470449 chr10:769945 NA 0.49 9.36 0.35 1.37e-19 Uric acid levels; BRCA cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14442939 chr10:27389572 ANKRD26 -0.68 -10.81 -0.39 3.87e-25 Breast cancer; BRCA cis rs1577917 0.518 rs2475787 chr6:86415236 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 8.94 0.33 4.24e-18 Response to antipsychotic treatment; BRCA cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg10802521 chr3:52805072 NEK4 -0.33 -8.52 -0.32 1.12e-16 Bipolar disorder; BRCA cis rs35146811 0.735 rs1636978 chr7:99813912 G/A cg13334819 chr7:99746414 C7orf59 0.4 9.17 0.34 6.36e-19 Coronary artery disease; BRCA cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA cis rs11098499 0.730 rs78971550 chr4:120281041 C/T cg09307838 chr4:120376055 NA 0.64 13.3 0.47 8.45e-36 Corneal astigmatism; BRCA cis rs12579753 0.956 rs7959951 chr12:82231132 T/C cg07988820 chr12:82153109 PPFIA2 -0.63 -10.3 -0.38 3.96e-23 Resting heart rate; BRCA cis rs4595586 0.525 rs7968458 chr12:39377139 C/A cg26384229 chr12:38710491 ALG10B 0.43 9.68 0.36 8.95e-21 Morning vs. evening chronotype; BRCA cis rs11098499 0.754 rs10212714 chr4:120254302 T/C cg09307838 chr4:120376055 NA 0.62 13.23 0.46 1.74e-35 Corneal astigmatism; BRCA cis rs1215050 0.755 rs9991112 chr4:98651479 A/C cg05340658 chr4:99064831 C4orf37 -0.41 -8.82 -0.33 1.05e-17 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs6429082 0.755 rs291384 chr1:235644300 C/T cg26050004 chr1:235667680 B3GALNT2 0.57 13.51 0.47 9.05e-37 Adiposity; BRCA cis rs6450176 0.909 rs66872223 chr5:53292730 T/C ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.11 -0.49 1.51e-39 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2073300 0.609 rs6137927 chr20:23372513 A/G cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.36e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7829975 0.606 rs10112585 chr8:8795030 A/T cg08975724 chr8:8085496 FLJ10661 -0.41 -8.83 -0.33 1.01e-17 Mood instability; BRCA cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.93 0.33 4.46e-18 Bladder cancer; BRCA cis rs10754283 0.901 rs10047070 chr1:90098715 G/C cg21401794 chr1:90099060 LRRC8C 0.49 11.82 0.42 2.58e-29 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs12681288 0.550 rs4410933 chr8:959581 A/G cg04851639 chr8:1020857 NA -0.3 -8.42 -0.32 2.52e-16 Schizophrenia; BRCA cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.17 0.31 1.67e-15 Uric acid levels; BRCA trans rs3733585 0.699 rs4473653 chr4:9971058 A/G cg26043149 chr18:55253948 FECH -0.36 -7.97 -0.3 7.39e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg06552810 chr11:31128660 NA 0.41 8.92 0.33 4.71e-18 Bone mineral density (spine); BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04267008 chr7:1944627 MAD1L1 0.53 12.06 0.43 2.52e-30 Bipolar disorder and schizophrenia; BRCA cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg23205692 chr1:25664452 TMEM50A 0.42 10.25 0.38 6.05e-23 Erythrocyte sedimentation rate; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg09060608 chr5:178986726 RUFY1 0.45 10.93 0.4 1.35e-25 Lung cancer; BRCA cis rs4718428 0.705 rs13227468 chr7:66433563 T/C cg12165864 chr7:66369176 NA -0.44 -9.74 -0.36 5.51e-21 Corneal structure; BRCA cis rs10754283 0.967 rs10754285 chr1:90116587 A/G cg21401794 chr1:90099060 LRRC8C 0.44 10.75 0.39 6.73e-25 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6565180 1.000 rs11863150 chr16:30385503 C/T cg17640201 chr16:30407289 ZNF48 0.79 20.72 0.63 2.41e-73 Tonsillectomy; BRCA cis rs12579753 0.917 rs12372724 chr12:82193628 C/T cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg14847009 chr1:175162515 KIAA0040 0.25 9.67 0.36 1.01e-20 Alcohol dependence; BRCA trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21659725 chr3:3221576 CRBN -0.49 -12.59 -0.45 1.28e-32 Intelligence (multi-trait analysis); BRCA cis rs4653767 1.000 rs708775 chr1:226923264 G/A cg05049329 chr1:226924846 ITPKB 0.34 9.68 0.36 8.64e-21 Parkinson's disease; BRCA cis rs782590 0.967 rs11125579 chr2:55739804 T/C cg18811423 chr2:55921094 PNPT1 0.65 19.5 0.61 8.25e-67 Metabolic syndrome; BRCA cis rs7809950 1.000 rs7782057 chr7:107098877 T/A cg23024343 chr7:107201750 COG5 -0.41 -9.64 -0.36 1.22e-20 Coronary artery disease; BRCA cis rs897984 0.520 rs12928081 chr16:30885159 T/G cg02466173 chr16:30829666 NA 0.46 9.11 0.34 1.01e-18 Dementia with Lewy bodies; BRCA cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg23711669 chr6:146136114 FBXO30 0.71 17.04 0.56 5.94e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs9815354 0.812 rs59476821 chr3:41946481 A/G cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.34 -10.96 -0.4 9.61e-26 Bipolar disorder; BRCA cis rs7851660 0.870 rs55960649 chr9:100598695 C/A cg13688889 chr9:100608707 NA -0.37 -8.88 -0.33 6.82e-18 Strep throat; BRCA cis rs910316 0.737 rs175077 chr14:75506875 G/A cg23033748 chr14:75592666 NEK9 -0.35 -8.09 -0.3 3.04e-15 Height; BRCA cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg13902645 chr11:5959945 NA 0.49 9.86 0.36 1.85e-21 DNA methylation (variation); BRCA cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg08280861 chr8:58055591 NA 0.53 11.56 0.42 3.4e-28 Developmental language disorder (linguistic errors); BRCA cis rs113835537 0.529 rs3892818 chr11:66240191 C/T cg24851651 chr11:66362959 CCS 0.41 8.02 0.3 5.11e-15 Airway imaging phenotypes; BRCA cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg14558114 chr2:88469736 THNSL2 0.63 9.14 0.34 8.32e-19 Plasma clusterin levels; BRCA cis rs7131987 0.644 rs6487817 chr12:29548210 G/A cg09582351 chr12:29534625 ERGIC2 0.43 9.82 0.36 2.7e-21 QT interval; BRCA cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg08392591 chr16:89556376 ANKRD11 0.41 9.45 0.35 6.38e-20 Multiple myeloma (IgH translocation); BRCA cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.84 -0.42 2.13e-29 Personality dimensions; BRCA trans rs208520 1.000 rs72884025 chr6:66994185 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.39 0.49 7.25e-41 Exhaled nitric oxide output; BRCA cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg06115741 chr20:33292138 TP53INP2 0.46 10.06 0.37 3.49e-22 Coronary artery disease; BRCA trans rs61931739 0.500 rs11053218 chr12:34474792 A/C cg13010199 chr12:38710504 ALG10B -0.48 -9.43 -0.35 7.55e-20 Morning vs. evening chronotype; BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg21782813 chr7:2030301 MAD1L1 -0.33 -9.59 -0.35 1.88e-20 Bipolar disorder and schizophrenia; BRCA trans rs11098499 0.644 rs10050092 chr4:120532085 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.06 0.37 3.22e-22 Corneal astigmatism; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg16606324 chr3:10149918 C3orf24 0.5 10.02 0.37 4.84e-22 Alzheimer's disease; BRCA cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2204008 0.805 rs4882575 chr12:37940573 G/A cg06521331 chr12:34319734 NA 0.44 8.55 0.32 8.78e-17 Bladder cancer; BRCA cis rs2625529 0.824 rs12899485 chr15:72143215 A/G cg16672083 chr15:72433130 SENP8 0.8 17.14 0.56 1.84e-54 Red blood cell count; BRCA cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg24562669 chr7:97807699 LMTK2 0.47 12.38 0.44 1.05e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs9325144 0.723 rs10161183 chr12:39182087 T/C cg26384229 chr12:38710491 ALG10B -0.51 -11.36 -0.41 2.3e-27 Morning vs. evening chronotype; BRCA cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg10295955 chr4:187884368 NA 0.95 27.98 0.74 4.52e-113 Lobe attachment (rater-scored or self-reported); BRCA cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.26 -0.41 6.16e-27 Colorectal cancer; BRCA cis rs61931739 0.534 rs1387789 chr12:34056304 C/A cg06521331 chr12:34319734 NA -0.63 -12.16 -0.43 9.6e-31 Morning vs. evening chronotype; BRCA cis rs10876993 0.928 rs2640631 chr12:58067532 A/T cg18357645 chr12:58087776 OS9 0.45 13.23 0.46 1.76e-35 Celiac disease or Rheumatoid arthritis; BRCA cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg11266682 chr4:10021025 SLC2A9 0.44 11.51 0.41 5.4e-28 Bone mineral density; BRCA cis rs9287719 0.967 rs6761678 chr2:10746341 T/C cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg16145915 chr7:1198662 ZFAND2A -0.38 -8.74 -0.33 2.05e-17 Longevity;Endometriosis; BRCA cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.27 -0.34 2.9e-19 Alzheimer's disease (late onset); BRCA cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg11301795 chr4:187892539 NA -0.29 -9.86 -0.36 1.99e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7246657 0.509 rs10426093 chr19:37615629 G/A cg18154014 chr19:37997991 ZNF793 0.5 8.06 0.3 3.66e-15 Coronary artery calcification; BRCA cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg06618935 chr21:46677482 NA 0.36 7.87 0.3 1.58e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.78 0.62 2.67e-68 Platelet count; BRCA cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 13.02 0.46 1.47e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9790314 0.613 rs1447619 chr3:160616077 A/T cg03342759 chr3:160939853 NMD3 0.43 8.56 0.32 8.3e-17 Morning vs. evening chronotype; BRCA cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.52 -0.32 1.15e-16 Aortic root size; BRCA cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.83 0.3 2.1e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.621 rs9374076 chr6:109597826 G/T cg01475377 chr6:109611718 NA -0.41 -8.17 -0.31 1.65e-15 Reticulocyte fraction of red cells; BRCA cis rs250677 0.687 rs42364 chr5:148438858 T/A cg18129178 chr5:148520854 ABLIM3 -0.59 -12.14 -0.43 1.19e-30 Breast cancer; BRCA cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg21132104 chr15:45694354 SPATA5L1 -0.68 -14.9 -0.51 2.51e-43 Homoarginine levels; BRCA cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs270601 0.683 rs81598 chr5:131587960 C/G cg18758796 chr5:131593413 PDLIM4 0.36 8.97 0.33 3.24e-18 Acylcarnitine levels; BRCA cis rs6745190 0.575 rs6710650 chr2:181972807 T/G cg00481216 chr2:181971175 NA 0.4 9.48 0.35 4.95e-20 White blood cell count; BRCA cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg25358565 chr5:93447407 FAM172A 1.18 18.2 0.58 5.96e-60 Diabetic retinopathy; BRCA cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg04450456 chr4:17643702 FAM184B 0.39 11.59 0.42 2.46e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg00409905 chr10:38381863 ZNF37A -0.49 -10.55 -0.39 4.19e-24 Extrinsic epigenetic age acceleration; BRCA cis rs6835098 1.000 rs4561909 chr4:174086937 A/T cg08422745 chr4:174089978 GALNT7 -0.76 -14.9 -0.51 2.71e-43 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1797081 0.901 rs703059 chr10:16876402 G/A cg23933602 chr10:16859644 RSU1 0.93 26.58 0.72 2.17e-105 Platelet distribution width; BRCA cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg15352829 chr14:105391018 PLD4 -0.38 -12.39 -0.44 9.37e-32 Rheumatoid arthritis; BRCA cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg21138405 chr5:131827807 IRF1 0.4 12.88 0.45 6.23e-34 Asthma (sex interaction); BRCA cis rs8180040 0.902 rs73081205 chr3:47517670 A/C cg16586182 chr3:47516702 SCAP 0.65 15.26 0.52 4.89e-45 Colorectal cancer; BRCA cis rs11105298 0.891 rs11105310 chr12:89918677 C/A cg00757033 chr12:89920650 WDR51B 0.54 11.08 0.4 3.24e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg00012203 chr2:219082015 ARPC2 0.57 12.2 0.43 6.67e-31 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs7178424 0.817 rs62007368 chr15:62318178 A/G cg00456672 chr15:62358751 C2CD4A -0.36 -8.02 -0.3 5.17e-15 Height; BRCA cis rs897080 0.552 rs1067392 chr2:44639097 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 8.89 0.33 6.19e-18 Height; BRCA cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg11266682 chr4:10021025 SLC2A9 -0.45 -11.52 -0.41 4.73e-28 Bone mineral density; BRCA trans rs4689592 0.503 rs3857180 chr4:7073899 T/G cg07817883 chr1:32538562 TMEM39B 0.48 7.86 0.3 1.67e-14 Monocyte percentage of white cells; BRCA cis rs10499694 0.901 rs6975453 chr7:50585211 A/T cg18232548 chr7:50535776 DDC -0.38 -9.09 -0.34 1.22e-18 Body mass index; BRCA cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg05340658 chr4:99064831 C4orf37 0.62 14.93 0.51 1.92e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg02297831 chr4:17616191 MED28 0.38 9.01 0.34 2.35e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35110281 0.837 rs2838342 chr21:45077865 G/A cg01579765 chr21:45077557 HSF2BP -0.42 -11.57 -0.42 3.04e-28 Mean corpuscular volume; BRCA cis rs2549003 1.000 rs2070728 chr5:131819977 C/T cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.65e-34 Asthma (sex interaction); BRCA cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg18016565 chr1:150552671 MCL1 -0.33 -8.04 -0.3 4.39e-15 Tonsillectomy; BRCA cis rs1371867 0.846 rs1788199 chr8:101292854 A/G cg06636551 chr8:101224915 SPAG1 -0.38 -8.59 -0.32 6.6e-17 Atrioventricular conduction; BRCA cis rs10782582 0.586 rs1856791 chr1:76308942 C/T cg03433033 chr1:76189801 ACADM -0.39 -8.09 -0.3 3.06e-15 Daytime sleep phenotypes; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs17095355 0.792 rs61881587 chr10:111759710 A/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.75 -0.36 5.07e-21 Biliary atresia; BRCA cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs4727027 0.901 rs6944781 chr7:148829566 A/G cg23583168 chr7:148888333 NA -0.79 -18.98 -0.6 4.88e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6700896 0.931 rs11208715 chr1:66154414 G/T cg04111102 chr1:66153794 NA 0.41 9.87 0.36 1.83e-21 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs7617480 0.648 rs6801211 chr3:48774420 C/G cg07636037 chr3:49044803 WDR6 0.89 20.89 0.64 2.82e-74 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs7582180 0.614 rs2241809 chr2:101014363 C/T cg14675211 chr2:100938903 LONRF2 0.51 11.37 0.41 2e-27 Intelligence (multi-trait analysis); BRCA cis rs9325144 0.555 rs7955128 chr12:38684121 A/T cg13010199 chr12:38710504 ALG10B 0.35 8.42 0.32 2.5e-16 Morning vs. evening chronotype; BRCA cis rs4234798 0.500 rs7661066 chr4:7219878 C/T cg18431297 chr4:7219810 SORCS2 0.38 10.67 0.39 1.43e-24 Insulin-like growth factors; BRCA cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg26384229 chr12:38710491 ALG10B -0.62 -16.12 -0.54 2.5e-49 Heart rate; BRCA cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg03517284 chr6:25882590 NA -0.51 -11.55 -0.42 3.53e-28 Blood metabolite levels; BRCA cis rs11249608 0.600 rs13359570 chr5:178449249 T/G cg21905437 chr5:178450457 ZNF879 0.51 10.66 0.39 1.59e-24 Pubertal anthropometrics; BRCA cis rs7301826 1.000 rs4759523 chr12:131315412 T/C cg11011512 chr12:131303247 STX2 0.43 10.92 0.4 1.37e-25 Plasma plasminogen activator levels; BRCA cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg09658497 chr7:2847517 GNA12 -0.39 -8.21 -0.31 1.23e-15 Height; BRCA cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg23711669 chr6:146136114 FBXO30 -0.78 -18.65 -0.59 2.56e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg04234412 chr22:24373322 LOC391322 -0.59 -14.47 -0.5 2.83e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9790314 0.543 rs1349352 chr3:161118486 C/T cg04691961 chr3:161091175 C3orf57 -0.38 -8.87 -0.33 7.09e-18 Morning vs. evening chronotype; BRCA cis rs1003719 0.680 rs8130069 chr21:38552116 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.01 -0.3 5.32e-15 Extrinsic epigenetic age acceleration; BRCA cis rs7264396 0.561 rs66483315 chr20:34573575 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -12.74 -0.45 2.71e-33 Total cholesterol levels; BRCA cis rs10242455 0.702 rs73711280 chr7:99039604 C/T cg18809830 chr7:99032528 PTCD1 -0.63 -8.98 -0.33 3.13e-18 Blood metabolite levels; BRCA cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg20503657 chr10:835505 NA 0.86 15.59 0.52 1.16e-46 Eosinophil percentage of granulocytes; BRCA trans rs3780486 0.801 rs10971424 chr9:33138775 T/C cg04842962 chr6:43655489 MRPS18A 1.12 39.23 0.84 2.61e-172 IgG glycosylation; BRCA cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg18876405 chr7:65276391 NA -0.55 -13.1 -0.46 6.87e-35 Aortic root size; BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg04944784 chr2:26401820 FAM59B 0.98 16.32 0.54 2.5e-50 Mean corpuscular hemoglobin; BRCA cis rs1983170 0.778 rs906241 chr1:92012154 G/T cg02896835 chr1:92012615 NA -0.4 -8.21 -0.31 1.18e-15 Eosinophil percentage of white cells; BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.58 0.47 4.5e-37 Platelet count; BRCA cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.31 -0.35 1.95e-19 Tonsillectomy; BRCA cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg06627628 chr2:24431161 ITSN2 -0.56 -9.06 -0.34 1.6e-18 Lymphocyte counts; BRCA cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg16850897 chr7:100343110 ZAN -0.58 -10.98 -0.4 8.04e-26 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg04414720 chr1:150670196 GOLPH3L 0.36 8.11 0.31 2.62e-15 Tonsillectomy; BRCA cis rs13046373 0.535 rs8129571 chr21:31980646 G/A cg24082983 chr21:31802169 KRTAP13-4 0.34 8.64 0.32 4.59e-17 HDL cholesterol; BRCA cis rs9469578 0.636 rs16869463 chr6:33714983 A/G cg18708504 chr6:33715942 IP6K3 -0.62 -9.51 -0.35 3.72e-20 Phosphorus levels; BRCA trans rs1997103 1.000 rs9649851 chr7:55398692 C/A cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.05e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs364477 0.762 rs9299104 chr9:1001254 C/T cg13952963 chr9:998547 NA -0.45 -8.13 -0.31 2.16e-15 Major depressive disorder; BRCA cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.28 -0.44 2.99e-31 Personality dimensions; BRCA cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg06784218 chr1:46089804 CCDC17 -0.42 -9.75 -0.36 4.8e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11190604 1.000 rs7078799 chr10:102301447 G/A cg07080220 chr10:102295463 HIF1AN 0.65 15.51 0.52 2.69e-46 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg11498726 chr8:26250323 BNIP3L 0.57 13.67 0.48 1.62e-37 Red cell distribution width; BRCA cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg12564285 chr5:131593104 PDLIM4 0.35 7.94 0.3 9.16e-15 Breast cancer; BRCA cis rs11098499 0.818 rs12498599 chr4:120468503 C/T cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg07636037 chr3:49044803 WDR6 0.5 8.26 0.31 8.19e-16 Menarche (age at onset); BRCA trans rs1493916 0.744 rs7504560 chr18:31312148 A/G cg15819921 chr19:927150 ARID3A -0.44 -8.41 -0.32 2.72e-16 Life satisfaction; BRCA cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9527 0.615 rs7089065 chr10:104723022 C/T cg04362960 chr10:104952993 NT5C2 0.45 10.42 0.38 1.39e-23 Arsenic metabolism; BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg00166722 chr3:10149974 C3orf24 0.65 12.8 0.45 1.54e-33 Alzheimer's disease; BRCA cis rs17095355 1.000 rs11194941 chr10:111744810 A/G cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.64 -0.36 1.26e-20 Biliary atresia; BRCA cis rs67981189 0.896 rs17108822 chr14:71445906 C/T cg15816911 chr14:71606274 NA 0.35 7.83 0.3 2.02e-14 Schizophrenia; BRCA cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg05283184 chr6:79620031 NA -0.42 -10.86 -0.39 2.46e-25 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.545 rs12816546 chr12:39398913 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.53e-19 Morning vs. evening chronotype; BRCA trans rs61931739 0.963 rs12298565 chr12:34036188 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.38 -0.35 1.09e-19 Morning vs. evening chronotype; BRCA cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.85 0.36 2.13e-21 Lung cancer in ever smokers; BRCA trans rs12517041 1.000 rs1428618 chr5:23282263 T/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs36051895 0.659 rs59225790 chr9:5042757 G/A cg02405213 chr9:5042618 JAK2 -0.5 -8.99 -0.34 2.67e-18 Pediatric autoimmune diseases; BRCA cis rs27434 0.583 rs468130 chr5:96156029 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.22e-33 Ankylosing spondylitis; BRCA cis rs925228 0.504 rs7568272 chr2:24313785 T/C cg01493198 chr2:24299560 SF3B14 0.62 9.94 0.37 9.39e-22 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.54 -0.32 9.79e-17 Total body bone mineral density; BRCA cis rs6912958 0.781 rs6916732 chr6:88259225 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.8e-16 Monocyte percentage of white cells; BRCA cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg08392591 chr16:89556376 ANKRD11 0.54 13.31 0.47 7.17e-36 Multiple myeloma (IgH translocation); BRCA cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg23029597 chr12:123009494 RSRC2 -0.63 -12.62 -0.45 9.28e-33 Body mass index; BRCA cis rs6963495 0.745 rs68153235 chr7:105184832 A/C cg19920283 chr7:105172520 RINT1 0.68 13.69 0.48 1.32e-37 Bipolar disorder (body mass index interaction); BRCA cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.3 0.38 3.9699999999999997e-23 Bipolar disorder; BRCA trans rs9467711 0.659 rs35680819 chr6:26455814 T/C cg01620082 chr3:125678407 NA -0.71 -8.38 -0.31 3.37e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg03354898 chr7:1950403 MAD1L1 -0.5 -10.1 -0.37 2.46e-22 Bipolar disorder and schizophrenia; BRCA cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg08999081 chr20:33150536 PIGU -0.33 -8.38 -0.31 3.37e-16 Glomerular filtration rate (creatinine); BRCA cis rs10464366 0.544 rs4540324 chr7:39185299 G/C cg18850127 chr7:39170497 POU6F2 0.54 11.82 0.42 2.62e-29 IgG glycosylation; BRCA cis rs11098499 0.774 rs11098505 chr4:120284627 C/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs2072499 0.554 rs1052067 chr1:156206121 C/T cg24450063 chr1:156163899 SLC25A44 0.66 13.05 0.46 1.17e-34 Testicular germ cell tumor; BRCA cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs367943 0.871 rs348940 chr5:112824530 C/A cg12552261 chr5:112820674 MCC -0.46 -10.43 -0.38 1.25e-23 Type 2 diabetes; BRCA trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg03929089 chr4:120376271 NA 0.75 17.1 0.56 2.77e-54 Coronary artery disease; BRCA cis rs9976767 0.637 rs2277799 chr21:43824123 G/C cg23042151 chr21:43824109 UBASH3A -0.28 -8.69 -0.33 2.99e-17 Type 1 diabetes; BRCA cis rs925228 0.550 rs11125393 chr2:24276736 T/C cg20701182 chr2:24300061 SF3B14 -0.47 -9.84 -0.36 2.27e-21 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs7264396 0.563 rs2425137 chr20:34345396 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -9.95 -0.37 8.98e-22 Total cholesterol levels; BRCA cis rs2625529 0.617 rs2306576 chr15:72170686 C/T cg16672083 chr15:72433130 SENP8 0.65 15.62 0.53 8.44e-47 Red blood cell count; BRCA cis rs11098499 0.908 rs12504149 chr4:120318577 G/A cg09307838 chr4:120376055 NA 0.73 15.87 0.53 4.5e-48 Corneal astigmatism; BRCA cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -9.14 -0.34 8.09e-19 Chronic sinus infection; BRCA cis rs6547741 1.000 rs10165098 chr2:27796526 C/T cg27432699 chr2:27873401 GPN1 0.45 9.7 0.36 7.44e-21 Oral cavity cancer; BRCA cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -8.3 -0.31 6.23e-16 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.524 rs2889855 chr20:33276853 A/G cg08999081 chr20:33150536 PIGU -0.31 -8.05 -0.3 4.12e-15 Glomerular filtration rate (creatinine); BRCA cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.53 -9.23 -0.34 3.8e-19 Schizophrenia; BRCA cis rs244731 1.000 rs244730 chr5:176539212 A/G cg16006841 chr5:176797999 RGS14 -0.7 -11.53 -0.42 4.43e-28 Urate levels in lean individuals; BRCA cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg24562669 chr7:97807699 LMTK2 0.61 18.04 0.58 4.1e-59 Breast cancer; BRCA trans rs6598955 0.671 rs58038522 chr1:26582713 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs7131987 0.650 rs10843384 chr12:29472409 C/T cg09582351 chr12:29534625 ERGIC2 -0.43 -9.85 -0.36 2.03e-21 QT interval; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg08742575 chr21:47604166 C21orf56 -0.4 -8.02 -0.3 5.11e-15 Testicular germ cell tumor; BRCA trans rs1994135 0.586 rs7308214 chr12:33713834 T/A cg26384229 chr12:38710491 ALG10B 0.55 11.45 0.41 9.86e-28 Resting heart rate; BRCA cis rs12472274 0.646 rs11688732 chr2:239096622 G/T cg17459225 chr2:239074497 NA 0.59 10.32 0.38 3.45e-23 Phospholipid levels (plasma); BRCA cis rs2742234 0.541 rs11238479 chr10:43717423 C/T cg15436174 chr10:43711423 RASGEF1A 0.54 10.61 0.39 2.56e-24 Hirschsprung disease; BRCA cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg20887711 chr4:1340912 KIAA1530 0.35 8.29 0.31 6.64e-16 Longevity; BRCA cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg00814883 chr7:100076585 TSC22D4 -0.47 -9.19 -0.34 5.45e-19 Platelet count; BRCA cis rs4780401 0.609 rs4781143 chr16:11809721 T/G cg01061890 chr16:11836724 TXNDC11 -0.55 -13.08 -0.46 8.07e-35 Rheumatoid arthritis; BRCA cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg13628971 chr7:2884303 GNA12 0.4 9.13 0.34 9.09e-19 Height; BRCA cis rs6435862 0.500 rs12477063 chr2:215673664 C/T cg04004882 chr2:215674386 BARD1 -0.68 -15.62 -0.53 8.21e-47 Neuroblastoma (high-risk); BRCA cis rs1829883 0.729 rs2548087 chr5:98907745 C/G cg08333243 chr5:99726346 NA 0.34 8.18 0.31 1.48e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg21573476 chr21:45109991 RRP1B -0.39 -10.14 -0.37 1.73e-22 Mean corpuscular volume; BRCA cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg06636001 chr8:8085503 FLJ10661 0.67 15.47 0.52 4.47e-46 Mood instability; BRCA cis rs751728 0.664 rs943478 chr6:33750940 T/A cg25922239 chr6:33757077 LEMD2 0.5 12.69 0.45 4.5e-33 Crohn's disease; BRCA cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.03 0.49 3.64e-39 Motion sickness; BRCA cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg08885076 chr2:99613938 TSGA10 -0.35 -7.96 -0.3 7.92e-15 Fear of minor pain; BRCA cis rs13102973 0.640 rs13151892 chr4:135831375 G/A cg14419869 chr4:135874104 NA 0.46 9.34 0.35 1.56e-19 Subjective well-being; BRCA cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.26 8.24 0.31 9.41e-16 Electroencephalogram traits; BRCA trans rs1997103 0.906 rs6593231 chr7:55402914 T/A cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg08822215 chr16:89438651 ANKRD11 -0.38 -8.09 -0.3 3.07e-15 Multiple myeloma (IgH translocation); BRCA cis rs10876993 0.928 rs774890 chr12:58068388 C/T cg18357645 chr12:58087776 OS9 0.47 13.56 0.47 5.44e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg20203395 chr5:56204925 C5orf35 -0.5 -10.11 -0.37 2.13e-22 Initial pursuit acceleration; BRCA cis rs2066819 1.000 rs79436528 chr12:56686997 C/T cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg15485101 chr11:133734466 NA -0.36 -8.48 -0.32 1.62e-16 Childhood ear infection; BRCA cis rs6121246 0.559 rs6060716 chr20:30274847 C/G cg21427119 chr20:30132790 HM13 -0.35 -7.9 -0.3 1.19e-14 Mean corpuscular hemoglobin; BRCA cis rs12579753 0.871 rs4255611 chr12:82215969 C/A cg07988820 chr12:82153109 PPFIA2 -0.51 -8.62 -0.32 5.17e-17 Resting heart rate; BRCA trans rs3733585 0.725 rs10939636 chr4:9972640 T/G cg26043149 chr18:55253948 FECH -0.36 -7.91 -0.3 1.12e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg22974920 chr21:40686053 BRWD1 -0.38 -8.59 -0.32 6.53e-17 Cognitive function; BRCA trans rs2727020 0.521 rs7114564 chr11:49571231 C/T cg15704280 chr7:45808275 SEPT13 0.69 13.99 0.48 5.45e-39 Coronary artery disease; BRCA cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg08085267 chr17:45401833 C17orf57 0.59 12.11 0.43 1.53e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg18479299 chr3:125709523 NA 0.53 8.21 0.31 1.26e-15 Blood pressure (smoking interaction); BRCA cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg12698349 chr2:225449008 CUL3 -0.59 -12.88 -0.45 6.46e-34 IgE levels in asthmatics (D.p. specific); BRCA cis rs7772486 0.686 rs9485019 chr6:146046381 C/G cg13319975 chr6:146136371 FBXO30 0.34 7.87 0.3 1.47e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs11608355 0.515 rs7311488 chr12:109930905 C/G cg05360138 chr12:110035743 NA -0.75 -13.92 -0.48 1.19e-38 Neuroticism; BRCA cis rs939658 0.683 rs1474256 chr15:79463847 C/T cg17916960 chr15:79447300 NA 0.37 8.95 0.33 3.71e-18 Refractive error; BRCA cis rs12367572 0.965 rs7952764 chr12:45246211 C/A cg04608330 chr12:45269318 NELL2 -0.58 -12.58 -0.45 1.33e-32 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg27170947 chr2:26402098 FAM59B 0.98 17.25 0.56 4.73e-55 Gut microbiome composition (summer); BRCA cis rs17401966 0.858 rs61778404 chr1:10432879 A/G cg03954927 chr1:10346856 KIF1B 0.49 15.14 0.51 1.78e-44 Hepatocellular carcinoma; BRCA cis rs7927771 1.000 rs11039426 chr11:47863119 G/A cg18512352 chr11:47633146 NA -0.35 -8.37 -0.31 3.64e-16 Subjective well-being; BRCA cis rs600806 0.888 rs11102971 chr1:109872370 C/T cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.5e-15 Intelligence (multi-trait analysis); BRCA cis rs12586317 0.547 rs28395170 chr14:35506988 C/T cg05294307 chr14:35346193 BAZ1A -0.6 -10.34 -0.38 2.91e-23 Psoriasis; BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg21782813 chr7:2030301 MAD1L1 0.38 9.77 0.36 4.24e-21 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.754 rs12506610 chr4:120241659 T/C cg09307838 chr4:120376055 NA 0.64 13.93 0.48 1.02e-38 Corneal astigmatism; BRCA cis rs514406 0.505 rs425520 chr1:53179805 C/G cg16325326 chr1:53192061 ZYG11B 0.9 24.8 0.7 1.28e-95 Monocyte count; BRCA cis rs61931739 0.517 rs4931771 chr12:34044557 G/A cg06521331 chr12:34319734 NA -0.62 -11.16 -0.4 1.46e-26 Morning vs. evening chronotype; BRCA cis rs2625529 0.824 rs12901886 chr15:72408069 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.57 -0.57 1.13e-56 Red blood cell count; BRCA cis rs427394 0.659 rs274725 chr5:6717408 C/G cg10857441 chr5:6722123 POLS -0.31 -9.97 -0.37 7.44e-22 Menopause (age at onset); BRCA cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg17524180 chr13:113633600 MCF2L -0.38 -9.4 -0.35 9.21e-20 Systolic blood pressure; BRCA cis rs2481665 0.546 rs2666504 chr1:62635081 T/C cg18591186 chr1:62594603 INADL 0.39 8.34 0.31 4.41e-16 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.2 0.41 1.02e-26 Bipolar disorder; BRCA cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg26373071 chr5:1325741 CLPTM1L 0.4 9.32 0.35 1.92e-19 Lung cancer; BRCA cis rs61931739 0.517 rs11612493 chr12:34114272 A/C cg06521331 chr12:34319734 NA -0.6 -11.18 -0.4 1.21e-26 Morning vs. evening chronotype; BRCA cis rs4363385 0.720 rs6665527 chr1:152967009 C/A cg21543102 chr1:152974771 SPRR3 -0.3 -8.47 -0.32 1.7e-16 Inflammatory skin disease; BRCA cis rs55692411 0.537 rs35375092 chr3:50065274 G/A cg05623727 chr3:50126028 RBM5 0.46 8.63 0.32 4.96e-17 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.967 rs9533689 chr13:44480413 A/C cg17145862 chr1:211918768 LPGAT1 0.69 18.15 0.58 1.04e-59 Leprosy; BRCA cis rs724568 0.546 rs1549778 chr2:67951297 G/T cg17945962 chr2:67939740 NA -0.38 -10.13 -0.37 1.8e-22 Major depressive disorder (broad); BRCA trans rs208520 0.507 rs7755710 chr6:66783355 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.14 -38.41 -0.84 3.67e-168 Exhaled nitric oxide output; BRCA cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg24296786 chr1:45957014 TESK2 -0.56 -13.19 -0.46 2.75e-35 High light scatter reticulocyte count; BRCA cis rs2832077 0.527 rs11088095 chr21:30223188 A/T cg08807101 chr21:30365312 RNF160 -0.55 -12.39 -0.44 9.7e-32 Cognitive test performance; BRCA trans rs17685 0.725 rs7807647 chr7:75628669 G/A cg19862616 chr7:65841803 NCRNA00174 -0.8 -25.3 -0.71 2.23e-98 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs3857536 0.505 rs208459 chr6:66911055 C/T cg07460842 chr6:66804631 NA -0.55 -9.91 -0.36 1.3e-21 Blood trace element (Cu levels); BRCA cis rs7586879 0.616 rs876186 chr2:25125585 C/T cg01884057 chr2:25150051 NA 0.35 9.26 0.34 3.07e-19 Body mass index; BRCA cis rs7481584 0.624 rs436580 chr11:3063961 T/G cg25174290 chr11:3078921 CARS -0.31 -8.17 -0.31 1.71e-15 Calcium levels; BRCA cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg06484146 chr7:12443880 VWDE -0.75 -10.68 -0.39 1.35e-24 Coronary artery disease; BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.36 0.41 2.24e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9399135 0.935 rs6908681 chr6:135337733 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.77e-31 Red blood cell count; BRCA cis rs11677370 0.561 rs10191326 chr2:3827524 G/C cg17052675 chr2:3827356 NA -0.56 -13.7 -0.48 1.2e-37 Type 2 diabetes; BRCA cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -8.96 -0.33 3.49e-18 Chronic sinus infection; BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg13047869 chr3:10149882 C3orf24 0.58 12.06 0.43 2.65e-30 Alzheimer's disease; BRCA cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg21475434 chr5:93447410 FAM172A 0.69 8.56 0.32 8.45e-17 Diabetic retinopathy; BRCA cis rs832540 0.618 rs41106 chr5:56145057 G/T cg12311346 chr5:56204834 C5orf35 -0.48 -9.84 -0.36 2.34e-21 Coronary artery disease; BRCA cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg26384229 chr12:38710491 ALG10B -0.55 -13.58 -0.47 4.27e-37 Morning vs. evening chronotype; BRCA cis rs9611565 0.694 rs202631 chr22:41863423 A/G cg19274703 chr22:41806451 NA -0.36 -9.07 -0.34 1.42e-18 Vitiligo; BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg00166722 chr3:10149974 C3orf24 -0.63 -11.07 -0.4 3.62e-26 Alzheimer's disease; BRCA cis rs9467773 0.967 rs1056347 chr6:26527524 G/C cg11502198 chr6:26597334 ABT1 0.48 9.63 0.36 1.36e-20 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.560 rs6088854 chr20:30225357 G/A cg13852791 chr20:30311386 BCL2L1 0.79 10.44 0.38 1.11e-23 Mean corpuscular hemoglobin; BRCA cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg01017244 chr2:74357527 NA 0.51 12.6 0.45 1.16e-32 Gestational age at birth (maternal effect); BRCA cis rs11249608 0.789 rs6868425 chr5:178446708 A/G cg21905437 chr5:178450457 ZNF879 0.52 10.76 0.39 6.33e-25 Pubertal anthropometrics; BRCA trans rs4718428 0.705 rs13227468 chr7:66433563 T/C cg18876405 chr7:65276391 NA 0.44 8.5 0.32 1.33e-16 Corneal structure; BRCA cis rs912057 0.671 rs1294428 chr6:6744623 A/G cg06612196 chr6:6737390 NA 0.46 10.85 0.39 2.81e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg10862848 chr6:42927986 GNMT -0.36 -14.93 -0.51 1.89e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg04025307 chr7:1156635 C7orf50 0.57 10.03 0.37 4.35e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs1459104 0.925 rs114730832 chr11:55189642 T/G cg15704280 chr7:45808275 SEPT13 0.66 8.14 0.31 2.03e-15 Body mass index; BRCA cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg21782813 chr7:2030301 MAD1L1 0.35 9.38 0.35 1.1e-19 Bipolar disorder and schizophrenia; BRCA cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg25237894 chr2:233734115 C2orf82 -0.43 -13.56 -0.47 5.32e-37 Coronary artery disease; BRCA cis rs919433 0.680 rs4685 chr2:198257795 C/T cg00792783 chr2:198669748 PLCL1 -0.38 -8.66 -0.32 3.79e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6964587 1.000 rs7784248 chr7:91758111 A/G cg17063962 chr7:91808500 NA 0.54 12.65 0.45 7.13e-33 Breast cancer; BRCA cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg27535305 chr1:53392650 SCP2 -0.38 -9.25 -0.34 3.4e-19 Monocyte count; BRCA cis rs1707322 0.752 rs4660880 chr1:46111040 C/T cg03146154 chr1:46216737 IPP 0.52 11.57 0.42 3.06e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg08085267 chr17:45401833 C17orf57 0.56 11.31 0.41 3.81e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs250677 0.687 rs1422581 chr5:148437386 C/T cg18129178 chr5:148520854 ABLIM3 0.58 12.1 0.43 1.73e-30 Breast cancer; BRCA cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.78 0.36 3.87e-21 Menopause (age at onset); BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg03709012 chr19:19516395 GATAD2A 0.72 15.68 0.53 4.14e-47 Tonsillectomy; BRCA cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg23711669 chr6:146136114 FBXO30 -0.72 -17.34 -0.57 1.7e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs9858542 0.953 rs6446264 chr3:49417243 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.24 -0.34 3.51e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg06636001 chr8:8085503 FLJ10661 0.73 16.08 0.54 4.22e-49 Neuroticism; BRCA cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg03146154 chr1:46216737 IPP 0.54 12.05 0.43 2.82e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs8073060 0.586 rs4796098 chr17:33913436 T/C cg19694781 chr19:47549865 TMEM160 1.05 21.6 0.65 4.24e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg14019146 chr3:50243930 SLC38A3 0.44 10.68 0.39 1.28e-24 Body mass index; BRCA cis rs2652834 0.904 rs2729827 chr15:63360564 C/T cg05507819 chr15:63340323 TPM1 0.5 9.76 0.36 4.7e-21 HDL cholesterol; BRCA cis rs6142102 0.625 rs4911381 chr20:32550345 C/G cg24642439 chr20:33292090 TP53INP2 -0.39 -7.85 -0.3 1.77e-14 Skin pigmentation; BRCA cis rs6433895 1.000 rs7566256 chr2:182013274 G/A cg00481216 chr2:181971175 NA 0.37 8.72 0.33 2.49e-17 Lymphocyte counts; BRCA cis rs4742903 0.904 rs7028408 chr9:106859811 G/A cg14250997 chr9:106856677 SMC2 0.34 10.74 0.39 7.43e-25 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2288912 0.808 rs35670684 chr19:45455985 A/C cg13119609 chr19:45449297 APOC2 0.47 13.1 0.46 6.65e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs2131877 0.529 rs4677810 chr3:194856747 G/C cg13868855 chr3:194833887 C3orf21 -0.36 -8.53 -0.32 1.1e-16 Non-small cell lung cancer; BRCA cis rs8180040 0.966 rs922957 chr3:47422152 G/C cg27129171 chr3:47204927 SETD2 -0.69 -16.2 -0.54 1.08e-49 Colorectal cancer; BRCA cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg11941060 chr3:133502564 NA -0.6 -14.63 -0.5 5.32e-42 Iron status biomarkers; BRCA cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg18016565 chr1:150552671 MCL1 0.34 7.83 0.3 2.03e-14 Melanoma; BRCA cis rs812925 0.519 rs2694627 chr2:61625506 A/G cg15711740 chr2:61764176 XPO1 0.33 8.1 0.31 2.86e-15 Immature fraction of reticulocytes; BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg27071517 chr21:31768726 KRTAP13-1 0.29 7.96 0.3 8.12e-15 HDL cholesterol; BRCA cis rs6815814 0.851 rs11466617 chr4:38780471 T/C cg06935464 chr4:38784597 TLR10 0.47 7.83 0.3 2e-14 Breast cancer; BRCA cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg08085267 chr17:45401833 C17orf57 0.6 12.26 0.44 3.47e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12618769 0.652 rs72823796 chr2:99227812 C/T cg10123293 chr2:99228465 UNC50 0.4 7.98 0.3 6.99e-15 Bipolar disorder; BRCA cis rs7824557 0.767 rs7837036 chr8:11175489 A/G cg21775007 chr8:11205619 TDH 0.65 12.68 0.45 5.2e-33 Retinal vascular caliber; BRCA cis rs6700896 0.897 rs2375805 chr1:66156567 C/T cg04111102 chr1:66153794 NA 0.34 8.49 0.32 1.48e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 9.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg11266682 chr4:10021025 SLC2A9 0.49 12.86 0.45 8.33e-34 Bone mineral density; BRCA cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg05347473 chr6:146136440 FBXO30 -0.6 -11.56 -0.42 3.47e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs6597981 0.675 rs4963120 chr11:825777 A/G cg01741372 chr11:783889 NA -0.42 -9.6 -0.36 1.75e-20 Breast cancer; BRCA cis rs274567 0.501 rs274571 chr5:131712125 A/G cg24060327 chr5:131705240 SLC22A5 0.61 11.36 0.41 2.18e-27 Blood metabolite levels; BRCA cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg24399712 chr22:39784796 NA -0.54 -12.04 -0.43 3.13e-30 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg23711669 chr6:146136114 FBXO30 0.77 17.91 0.58 2.01e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg16145915 chr7:1198662 ZFAND2A -0.56 -13.04 -0.46 1.22e-34 Longevity;Endometriosis; BRCA cis rs55882075 0.967 rs12656648 chr5:179152106 C/A cg14593053 chr5:179126677 CANX 0.4 10.16 0.37 1.37e-22 Monocyte percentage of white cells; BRCA cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg13284614 chr3:52569169 NT5DC2;LOC440957 0.29 8.03 0.3 4.6e-15 Electroencephalogram traits; BRCA cis rs3784262 0.669 rs12915821 chr15:58315685 A/G cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.18 -0.37 1.16e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs798766 1.000 rs798766 chr4:1734239 C/T cg05874882 chr4:1763078 NA 0.45 8.25 0.31 8.9e-16 Bladder cancer;Urinary bladder cancer; BRCA cis rs35740288 0.539 rs11629991 chr15:86336664 A/G cg20737812 chr15:86336631 KLHL25 -0.4 -9.8 -0.36 3.18e-21 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg11843238 chr5:131593191 PDLIM4 0.4 9.51 0.35 3.81e-20 Acylcarnitine levels; BRCA cis rs3008870 0.727 rs4582760 chr1:67464394 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.64 -14.03 -0.49 3.54e-39 Lymphocyte percentage of white cells; BRCA cis rs6893300 0.524 rs12374446 chr5:179131143 A/G cg14593053 chr5:179126677 CANX 0.45 11.91 0.43 1.18e-29 Resting heart rate; BRCA cis rs2836950 0.545 rs2836922 chr21:40516308 C/T cg11890956 chr21:40555474 PSMG1 -0.59 -12.85 -0.45 9.25e-34 Menarche (age at onset); BRCA cis rs8072100 0.713 rs57427906 chr17:45494014 G/A cg25173405 chr17:45401733 C17orf57 -0.51 -10.66 -0.39 1.57e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs8064299 0.967 rs880827 chr17:72767435 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.41 -11.6 -0.42 2.3e-28 Monocyte count; BRCA cis rs11098499 0.863 rs3822194 chr4:120471648 A/G cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg25358565 chr5:93447407 FAM172A 1.22 19.39 0.61 3.06e-66 Diabetic retinopathy; BRCA trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg11887960 chr12:57824829 NA 0.55 8.5 0.32 1.29e-16 Lung disease severity in cystic fibrosis; BRCA cis rs425277 0.958 rs262687 chr1:2117155 G/A cg24578937 chr1:2090814 PRKCZ 0.59 17.73 0.57 1.76e-57 Height; BRCA cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg25173405 chr17:45401733 C17orf57 0.54 11.03 0.4 4.96e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs8114671 0.647 rs1124511 chr20:33736697 A/C cg07148914 chr20:33460835 GGT7 0.35 7.9 0.3 1.22e-14 Height; BRCA cis rs10751667 0.600 rs14346 chr11:1011829 T/C ch.11.42038R chr11:967971 AP2A2 0.47 14.32 0.49 1.45e-40 Alzheimer's disease (late onset); BRCA cis rs4363385 0.818 rs423692 chr1:153005681 T/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.19e-19 Inflammatory skin disease; BRCA cis rs2806561 0.769 rs2235547 chr1:23406485 C/G cg19743168 chr1:23544995 NA -0.41 -9.67 -0.36 9.66e-21 Height; BRCA cis rs4363385 0.747 rs9919276 chr1:152968654 A/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.82 -0.3 2.21e-14 Inflammatory skin disease; BRCA cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg13256891 chr4:100009986 ADH5 0.43 8.88 0.33 6.76e-18 Alcohol dependence; BRCA cis rs2153535 0.584 rs62395677 chr6:8371589 G/A cg21535247 chr6:8435926 SLC35B3 -0.37 -8.37 -0.31 3.54e-16 Motion sickness; BRCA trans rs9329221 0.935 rs6601450 chr8:10243101 G/T cg15556689 chr8:8085844 FLJ10661 0.37 9.92 0.37 1.13e-21 Neuroticism; BRCA cis rs6594499 0.872 rs1379300 chr5:110441439 A/G cg04022379 chr5:110408740 TSLP 0.36 7.99 0.3 6.14e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.32 -0.35 1.91e-19 Alzheimer's disease (late onset); BRCA cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg17173187 chr15:85201210 NMB 0.43 8.92 0.33 4.78e-18 Schizophrenia; BRCA cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.03 0.4 5.08e-26 Electroencephalogram traits; BRCA cis rs9486719 0.522 rs4839683 chr6:96851933 A/G cg06623918 chr6:96969491 KIAA0776 0.74 15.45 0.52 5.39e-46 Migraine;Coronary artery disease; BRCA cis rs4285028 0.656 rs2141487 chr3:121482765 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.89 16.79 0.55 1.07e-52 Multiple sclerosis; BRCA cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.99e-35 Bone mineral density; BRCA cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg21427119 chr20:30132790 HM13 0.41 8.75 0.33 1.9e-17 Mean corpuscular hemoglobin; BRCA cis rs3768617 0.510 rs6424888 chr1:183085696 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.63 -17.06 -0.56 4.52e-54 Fuchs's corneal dystrophy; BRCA cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg01877450 chr7:97915802 BRI3 -0.38 -8.6 -0.32 6.09e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2180341 0.782 rs6924274 chr6:127721556 T/A cg24812749 chr6:127587940 RNF146 0.68 15.5 0.52 2.95e-46 Breast cancer; BRCA trans rs9291683 0.551 rs62295971 chr4:9978142 G/A cg26043149 chr18:55253948 FECH 0.4 8.9 0.33 5.72e-18 Bone mineral density; BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg00814883 chr7:100076585 TSC22D4 -0.49 -10.18 -0.37 1.13e-22 Platelet count; BRCA cis rs13394619 0.605 rs12476152 chr2:11747960 T/C cg07314298 chr2:11723111 GREB1 0.36 8.12 0.31 2.39e-15 Endometriosis; BRCA cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 10.56 0.39 3.9e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11051970 0.879 rs2728680 chr12:32583512 T/C cg24626660 chr12:32551988 NA 0.29 8.2 0.31 1.28e-15 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs17685 0.712 rs2158867 chr7:75815141 C/A cg19862616 chr7:65841803 NCRNA00174 0.79 24.67 0.7 6.78e-95 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg00106254 chr7:1943704 MAD1L1 0.4 10.34 0.38 2.91e-23 Bipolar disorder and schizophrenia; BRCA cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg06784218 chr1:46089804 CCDC17 0.52 12.3 0.44 2.31e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9814567 1.000 rs10804632 chr3:134294501 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.96 -0.33 3.65e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12681288 0.550 rs4637864 chr8:959761 C/T cg04851639 chr8:1020857 NA -0.29 -8.23 -0.31 1.07e-15 Schizophrenia; BRCA cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.84 -0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg17063962 chr7:91808500 NA -0.54 -12.26 -0.44 3.46e-31 Breast cancer; BRCA cis rs10838687 0.736 rs7118396 chr11:47269936 C/T cg25783544 chr11:47291846 MADD 0.46 8.62 0.32 5.23e-17 Proinsulin levels; BRCA cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg16558253 chr16:72132732 DHX38 0.48 11.14 0.4 1.81e-26 Fibrinogen levels; BRCA cis rs2835872 0.758 rs1709833 chr21:39037805 C/T cg06728970 chr21:39037746 KCNJ6 -0.45 -13.2 -0.46 2.31e-35 Electroencephalographic traits in alcoholism; BRCA cis rs6570726 0.846 rs441575 chr6:145849205 A/C cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs4566357 0.615 rs12621808 chr2:227909522 A/C cg11843606 chr2:227700838 RHBDD1 -0.41 -9.29 -0.34 2.48e-19 Coronary artery disease; BRCA cis rs34779708 0.966 rs4934538 chr10:35472150 T/C cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.82e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg05234568 chr11:5960015 NA -0.42 -8.79 -0.33 1.35e-17 DNA methylation (variation); BRCA cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg05868516 chr6:26286170 HIST1H4H 0.46 10.07 0.37 3.01e-22 Educational attainment; BRCA cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg20090143 chr19:45452003 APOC2 0.27 8.04 0.3 4.44e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.59 0.32 6.82e-17 Glomerular filtration rate (creatinine); BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.54 8.59 0.32 6.7e-17 Renal function-related traits (BUN); BRCA cis rs3857536 0.740 rs9354390 chr6:66890162 C/T cg07460842 chr6:66804631 NA 0.46 8.83 0.33 9.74e-18 Blood trace element (Cu levels); BRCA cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11890956 chr21:40555474 PSMG1 1.1 34.02 0.8 1.5e-145 Cognitive function; BRCA cis rs875971 0.862 rs2088653 chr7:65808608 G/A cg18876405 chr7:65276391 NA -0.5 -11.18 -0.4 1.25e-26 Aortic root size; BRCA trans rs8073060 0.586 rs7217533 chr17:34015876 A/G cg19694781 chr19:47549865 TMEM160 -1.06 -21.42 -0.65 4.16e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11890956 chr21:40555474 PSMG1 1.05 29.65 0.76 3.7e-122 Cognitive function; BRCA cis rs9388451 0.626 rs1739384 chr6:126099246 C/A cg05901451 chr6:126070800 HEY2 -0.55 -14.54 -0.5 1.4e-41 Brugada syndrome; BRCA cis rs1555322 0.530 rs6060347 chr20:33874151 A/G cg17927777 chr20:33865990 NA 0.42 7.86 0.3 1.64e-14 Attention deficit hyperactivity disorder; BRCA cis rs7666738 0.830 rs34135615 chr4:99001325 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg04455712 chr21:45112962 RRP1B 0.46 12.52 0.44 2.52e-32 Mean corpuscular volume; BRCA cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg19077165 chr18:44547161 KATNAL2 -0.58 -12.67 -0.45 5.65e-33 Personality dimensions; BRCA cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg22117172 chr7:91764530 CYP51A1 0.23 7.83 0.3 1.99e-14 Breast cancer; BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg13012494 chr21:47604986 C21orf56 0.44 8.71 0.33 2.53e-17 Testicular germ cell tumor; BRCA cis rs6598955 0.671 rs58038522 chr1:26582713 C/T cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg27478167 chr7:817139 HEATR2 -0.43 -9.06 -0.34 1.63e-18 Cerebrospinal P-tau181p levels; BRCA cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg02153584 chr22:29168773 CCDC117 -0.45 -8.93 -0.33 4.46e-18 Lymphocyte counts; BRCA cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg16145915 chr7:1198662 ZFAND2A 0.62 14.93 0.51 1.93e-43 Longevity;Endometriosis; BRCA cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.24 -0.31 9.76e-16 Bipolar disorder; BRCA cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg18225595 chr11:63971243 STIP1 0.5 9.25 0.34 3.21e-19 Mean platelet volume; BRCA cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg03425785 chr20:62221387 GMEB2 0.52 8.36 0.31 4.02e-16 Glioblastoma; BRCA cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg05234568 chr11:5960015 NA -0.49 -10.26 -0.38 5.69e-23 DNA methylation (variation); BRCA cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg01483505 chr11:975446 AP2A2 0.34 9.1 0.34 1.17e-18 Alzheimer's disease (late onset); BRCA cis rs7945718 0.967 rs10831906 chr11:12783042 C/T cg25843174 chr11:12811716 TEAD1 0.23 8.89 0.33 6.39e-18 Educational attainment (years of education); BRCA cis rs965469 1.000 rs2236087 chr20:3255905 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -9.84 -0.36 2.38e-21 IFN-related cytopenia; BRCA trans rs11088226 0.846 rs2154500 chr21:33926391 T/C cg09050820 chr6:167586206 TCP10L2 0.57 10.84 0.39 3.03e-25 Gastritis; BRCA cis rs796364 0.589 rs55700082 chr2:201135669 G/A cg23649088 chr2:200775458 C2orf69 -0.48 -8.06 -0.3 3.74e-15 Schizophrenia; BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg02951883 chr7:2050386 MAD1L1 0.55 12.55 0.44 1.9e-32 Bipolar disorder and schizophrenia; BRCA cis rs2625529 0.652 rs2034879 chr15:72429989 A/G cg16672083 chr15:72433130 SENP8 -0.72 -17.52 -0.57 1.96e-56 Red blood cell count; BRCA cis rs4689388 0.793 rs4234731 chr4:6299914 A/G cg00701064 chr4:6280414 WFS1 0.71 18.37 0.59 7.35e-61 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs507080 0.883 rs563549 chr11:118558953 G/A cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs61931739 0.500 rs7310237 chr12:34483435 G/A cg06521331 chr12:34319734 NA -0.51 -10.11 -0.37 2.15e-22 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs785493 chr1:46584859 A/G cg06784218 chr1:46089804 CCDC17 -0.47 -10.55 -0.39 4.12e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg11843238 chr5:131593191 PDLIM4 0.35 7.99 0.3 6.49e-15 Breast cancer; BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.9 0.33 5.92e-18 Tonsillectomy; BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg04267008 chr7:1944627 MAD1L1 0.66 13.96 0.48 7.44e-39 Bipolar disorder and schizophrenia; BRCA trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg03929089 chr4:120376271 NA 0.61 10.41 0.38 1.52e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs758324 0.617 rs9717078 chr5:131170891 G/A cg06307176 chr5:131281290 NA 0.53 10.3 0.38 3.86e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg20848291 chr7:100343083 ZAN -0.62 -12.98 -0.46 2.44e-34 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6545883 0.929 rs778140 chr2:61682976 C/T cg15711740 chr2:61764176 XPO1 -0.53 -12.75 -0.45 2.49e-33 Tuberculosis; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg21782813 chr7:2030301 MAD1L1 0.42 11.38 0.41 1.82e-27 Bipolar disorder and schizophrenia; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg10862848 chr6:42927986 GNMT -0.36 -15.04 -0.51 5.55e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1953600 0.870 rs2573370 chr10:81951366 C/T cg04850286 chr10:81895943 PLAC9 0.32 9.0 0.34 2.57e-18 Sarcoidosis; BRCA cis rs3849570 0.961 rs11710970 chr3:81693489 T/C cg07356753 chr3:81810745 GBE1 -0.45 -10.65 -0.39 1.75e-24 Waist circumference;Body mass index; BRCA cis rs528301 0.613 rs4143310 chr2:45124563 C/A cg02372786 chr2:45167549 SIX3 -0.42 -9.29 -0.34 2.4e-19 Alcohol and nicotine co-dependence; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg03923535 chr7:1197113 ZFAND2A 0.52 11.39 0.41 1.73e-27 Longevity;Endometriosis; BRCA cis rs1538970 0.962 rs2153608 chr1:45813941 C/T cg05343316 chr1:45956843 TESK2 -0.49 -10.14 -0.37 1.74e-22 Platelet count; BRCA cis rs7264396 0.563 rs2425138 chr20:34345710 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.19 -0.4 1.12e-26 Total cholesterol levels; BRCA cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -9.45 -0.35 6.3e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg10523679 chr1:76189770 ACADM 0.7 12.64 0.45 7.81e-33 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs919433 0.713 rs13411968 chr2:198467141 C/T cg00792783 chr2:198669748 PLCL1 0.35 8.04 0.3 4.49e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs8005677 1.000 rs11157930 chr14:23403171 T/G cg23176270 chr14:23476067 C14orf93 0.38 7.85 0.3 1.8e-14 Cognitive ability (multi-trait analysis); BRCA cis rs3768617 0.510 rs3768629 chr1:183074582 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.73 0.57 1.73e-57 Fuchs's corneal dystrophy; BRCA cis rs13191362 0.507 rs2849540 chr6:163094522 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.48 -8.97 -0.33 3.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg11663144 chr21:46675770 NA -0.57 -13.58 -0.47 4.41e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 0.722 rs10404031 chr19:38035954 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.17 0.34 6.65e-19 Coronary artery calcification; BRCA cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg21918786 chr6:109611834 NA -0.49 -14.04 -0.49 3.14e-39 Reticulocyte fraction of red cells; BRCA cis rs7246967 0.673 rs2361023 chr19:22816867 C/T cg23217946 chr19:22817039 ZNF492 0.47 8.45 0.32 2e-16 Bronchopulmonary dysplasia; BRCA cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg24130564 chr14:104152367 KLC1 -0.41 -8.73 -0.33 2.2e-17 Reticulocyte count; BRCA cis rs2522056 1.000 rs6874639 chr5:131778716 C/T cg24060327 chr5:131705240 SLC22A5 -0.45 -8.13 -0.31 2.3e-15 Lymphocyte counts;Fibrinogen; BRCA cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg20701182 chr2:24300061 SF3B14 0.67 9.72 0.36 6.39e-21 Lymphocyte counts; BRCA cis rs9818758 0.607 rs35060561 chr3:49255503 T/C cg01304814 chr3:48885189 PRKAR2A 0.63 7.81 0.3 2.43e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA trans rs72766638 0.895 rs72766630 chr9:136926791 G/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.66 -9.41 -0.35 9.04e-20 Mosquito bite size; BRCA cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.570 rs12318341 chr12:38251087 T/C cg26384229 chr12:38710491 ALG10B -0.44 -10.06 -0.37 3.4e-22 Bladder cancer; BRCA cis rs10870270 1.000 rs4880246 chr10:133764064 C/T cg08754478 chr10:133766260 PPP2R2D -0.68 -14.05 -0.49 2.85e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg11822812 chr5:140052017 DND1 -0.29 -8.06 -0.3 3.63e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9443645 0.505 rs11752126 chr6:79707923 C/T cg09184832 chr6:79620586 NA -0.43 -8.45 -0.32 2.03e-16 Intelligence (multi-trait analysis); BRCA cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg14036092 chr11:66035641 RAB1B 0.39 10.56 0.39 4e-24 Gout; BRCA cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg06108461 chr20:60628389 TAF4 -0.79 -17.05 -0.56 5.51e-54 Body mass index; BRCA cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg08213375 chr14:104286397 PPP1R13B 0.51 11.4 0.41 1.5e-27 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg12311346 chr5:56204834 C5orf35 -0.71 -13.71 -0.48 1.08e-37 Initial pursuit acceleration; BRCA cis rs6088580 0.634 rs11700221 chr20:32940320 T/C cg08999081 chr20:33150536 PIGU -0.46 -12.58 -0.45 1.44e-32 Glomerular filtration rate (creatinine); BRCA cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg11644478 chr21:40555479 PSMG1 0.66 14.67 0.5 3.4e-42 Cognitive function; BRCA cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs1493916 0.967 rs1389532 chr18:31392323 C/T cg27147174 chr7:100797783 AP1S1 -0.54 -10.89 -0.4 1.83e-25 Life satisfaction; BRCA cis rs2991971 0.967 rs937291 chr1:45957039 G/T cg15605315 chr1:45957053 TESK2 0.5 10.26 0.38 5.99e-23 High light scatter reticulocyte count; BRCA cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg11663144 chr21:46675770 NA -0.64 -15.28 -0.52 3.78e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9287719 0.674 rs11691060 chr2:10827061 T/C cg00105475 chr2:10696890 NA -0.38 -8.75 -0.33 1.89e-17 Prostate cancer; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.52 10.44 0.38 1.18e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg05863683 chr7:1912471 MAD1L1 0.38 8.45 0.32 1.98e-16 Schizophrenia; BRCA cis rs7086627 0.515 rs10887901 chr10:82210581 G/A cg00277334 chr10:82204260 NA -0.85 -25.12 -0.7 2.25e-97 Post bronchodilator FEV1; BRCA cis rs1003719 0.715 rs8126941 chr21:38551542 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.56 -12.58 -0.45 1.38e-32 Eye color traits; BRCA cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg12011299 chr4:100065546 ADH4 0.52 15.4 0.52 9.48e-46 Alcohol dependence; BRCA cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6920965 0.527 rs584032 chr6:126165003 G/A cg05901451 chr6:126070800 HEY2 0.37 8.98 0.33 3.08e-18 High light scatter reticulocyte count; BRCA cis rs12950390 0.814 rs11659069 chr17:45834275 G/T cg24803719 chr17:45855879 NA -0.31 -8.44 -0.32 2.05e-16 IgG glycosylation; BRCA trans rs4689592 0.587 rs6825954 chr4:7074226 T/C cg07817883 chr1:32538562 TMEM39B -0.47 -8.73 -0.33 2.17e-17 Monocyte percentage of white cells; BRCA cis rs7551345 0.851 rs10914330 chr1:31691577 A/C cg19084893 chr1:31688959 NA 0.41 8.15 0.31 1.89e-15 Schizophrenia; BRCA cis rs11190604 0.767 rs11190531 chr10:102187310 T/A cg07080220 chr10:102295463 HIF1AN 0.5 10.36 0.38 2.43e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs3125734 0.633 rs4979754 chr10:64048959 G/A cg09941381 chr10:64027924 RTKN2 -0.3 -8.34 -0.31 4.72e-16 Rheumatoid arthritis; BRCA cis rs9467773 1.000 rs4713006 chr6:26519872 A/G cg09904177 chr6:26538194 HMGN4 0.57 18.5 0.59 1.63e-61 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.927 rs6915834 chr6:25935427 A/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.83 0.36 2.59e-21 Height; BRCA cis rs9470366 0.816 rs1321311 chr6:36622900 C/A cg08179530 chr6:36648295 CDKN1A 0.5 10.27 0.38 5.13e-23 QRS duration; BRCA cis rs9790314 0.586 rs11710086 chr3:161125858 A/T cg03342759 chr3:160939853 NMD3 -0.63 -14.2 -0.49 5.41e-40 Morning vs. evening chronotype; BRCA trans rs11976180 1.000 rs2961118 chr7:143755443 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.44 -8.25 -0.31 9.38e-16 Obesity-related traits; BRCA cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24110177 chr3:50126178 RBM5 -0.37 -9.86 -0.36 1.85e-21 Intelligence (multi-trait analysis); BRCA cis rs2832191 0.740 rs2832175 chr21:30475606 A/G cg08807101 chr21:30365312 RNF160 -0.74 -19.7 -0.61 6.94e-68 Dental caries; BRCA cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg22496339 chr2:162101262 NA 0.58 13.1 0.46 6.84e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg22875332 chr1:76189707 ACADM 0.79 18.87 0.6 1.86e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.4 -0.61 2.69e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg01579765 chr21:45077557 HSF2BP -0.38 -10.06 -0.37 3.26e-22 Mean corpuscular volume; BRCA trans rs60843830 1.000 rs3791223 chr2:222336 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.68 0.5 3.07e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs11098499 0.954 rs878373 chr4:120237484 A/T cg09307838 chr4:120376055 NA 0.69 14.53 0.5 1.49e-41 Corneal astigmatism; BRCA cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg03425785 chr20:62221387 GMEB2 0.51 8.28 0.31 7.22e-16 Glioblastoma; BRCA cis rs7647973 0.626 rs1996664 chr3:49878395 A/G cg03060546 chr3:49711283 APEH -0.58 -10.13 -0.37 1.81e-22 Menarche (age at onset); BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.71e-14 Tonsillectomy; BRCA trans rs2204008 0.640 rs11520199 chr12:38211026 T/C cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs1580019 0.844 rs1584615 chr7:32503258 G/C cg06627557 chr7:32535165 LSM5;AVL9 0.89 19.71 0.61 6.44e-68 Cognitive ability; BRCA cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg11764359 chr7:65958608 NA -0.75 -16.67 -0.55 4.55e-52 Aortic root size; BRCA cis rs3768617 0.811 rs12066082 chr1:183054863 G/C ch.1.3577855R chr1:183094577 LAMC1 0.45 9.87 0.36 1.82e-21 Fuchs's corneal dystrophy; BRCA cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.67e-36 Chronic sinus infection; BRCA cis rs524281 0.861 rs10896091 chr11:65950825 T/C cg16950941 chr11:66035639 RAB1B -0.37 -7.87 -0.3 1.57e-14 Electroencephalogram traits; BRCA cis rs7551222 0.752 rs4951407 chr1:204558070 G/T cg20240347 chr1:204465584 NA 0.29 9.28 0.34 2.58e-19 Schizophrenia; BRCA cis rs425277 0.958 rs262688 chr1:2113565 T/G cg24578937 chr1:2090814 PRKCZ 0.59 17.96 0.58 1.12e-58 Height; BRCA cis rs11098499 0.691 rs17009144 chr4:120270795 C/T cg09307838 chr4:120376055 NA -0.59 -12.96 -0.46 2.85e-34 Corneal astigmatism; BRCA trans rs9858542 0.953 rs6446264 chr3:49417243 C/A cg21659725 chr3:3221576 CRBN -0.46 -10.04 -0.37 4.1e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -12.21 -0.43 6.04e-31 Mood instability; BRCA cis rs9309473 1.000 rs6753344 chr2:73653138 C/T cg20560298 chr2:73613845 ALMS1 0.41 10.12 0.37 1.97e-22 Metabolite levels; BRCA cis rs724568 0.546 rs6717648 chr2:67939688 C/T cg14046302 chr2:67939758 NA -0.4 -10.63 -0.39 2.06e-24 Major depressive disorder (broad); BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg00166722 chr3:10149974 C3orf24 0.64 11.12 0.4 2.21e-26 Alzheimer's disease; BRCA cis rs2859741 0.967 rs575939 chr1:37513854 T/C cg09363841 chr1:37513479 NA -0.67 -16.97 -0.56 1.3e-53 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg05863683 chr7:1912471 MAD1L1 0.42 9.79 0.36 3.48e-21 Bipolar disorder and schizophrenia; BRCA cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg06115741 chr20:33292138 TP53INP2 0.36 8.13 0.31 2.23e-15 Glomerular filtration rate (creatinine); BRCA cis rs6121246 0.609 rs6089075 chr20:30392884 A/G cg13852791 chr20:30311386 BCL2L1 0.83 17.89 0.58 2.39e-58 Mean corpuscular hemoglobin; BRCA cis rs2964802 0.505 rs13180011 chr5:10824615 T/C cg14521931 chr5:10832172 NA -0.58 -12.62 -0.45 8.97e-33 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs2073300 1.000 rs6137962 chr20:23443966 T/C cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7147624 1.000 rs10873192 chr14:66110653 A/G cg03016385 chr14:66212404 NA -0.58 -8.97 -0.33 3.27e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.97 0.53 1.54e-48 Platelet count; BRCA cis rs10540 0.908 rs1044707 chr11:491334 G/T cg19913688 chr11:428466 ANO9 0.64 9.3 0.35 2.11e-19 Body mass index; BRCA cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24308560 chr3:49941425 MST1R -0.4 -8.57 -0.32 7.82e-17 Intelligence (multi-trait analysis); BRCA cis rs11971779 1.000 rs11971779 chr7:139040258 A/G cg07862535 chr7:139043722 LUC7L2 -0.49 -12.01 -0.43 4.3e-30 Diisocyanate-induced asthma; BRCA cis rs2243480 1.000 rs316327 chr7:65609201 G/T cg18252515 chr7:66147081 NA 1.02 14.96 0.51 1.27e-43 Diabetic kidney disease; BRCA cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24110177 chr3:50126178 RBM5 0.41 11.39 0.41 1.74e-27 Intelligence (multi-trait analysis); BRCA cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg05294307 chr14:35346193 BAZ1A -0.6 -11.68 -0.42 1.04e-28 Psoriasis; BRCA cis rs11229555 0.645 rs61905183 chr11:58228463 T/A cg15696309 chr11:58395628 NA -0.53 -10.99 -0.4 7.54e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg08999081 chr20:33150536 PIGU 0.49 13.81 0.48 3.59e-38 Coronary artery disease; BRCA cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.43 0.35 7.61e-20 Tonsillectomy; BRCA cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg16230307 chr14:35515116 FAM177A1 0.62 14.02 0.48 4.11e-39 Psoriasis; BRCA cis rs9329289 0.510 rs1155447 chr10:2553240 C/T cg15501526 chr10:2543763 NA 0.41 9.51 0.35 3.69e-20 Age-related hearing impairment; BRCA cis rs2239547 0.522 rs6445550 chr3:52983434 G/A cg11645453 chr3:52864694 ITIH4 0.45 10.7 0.39 1.05e-24 Schizophrenia; BRCA cis rs2354432 0.505 rs3737845 chr1:146724408 A/G cg25205988 chr1:146714368 CHD1L 0.92 12.09 0.43 1.85e-30 Mitochondrial DNA levels; BRCA cis rs4319547 0.585 rs7952868 chr12:122846949 A/G cg23029597 chr12:123009494 RSRC2 -0.61 -11.21 -0.41 9.18e-27 Body mass index; BRCA cis rs3768617 0.811 rs12138049 chr1:182979546 C/T ch.1.3577855R chr1:183094577 LAMC1 0.45 9.88 0.36 1.55e-21 Fuchs's corneal dystrophy; BRCA cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg11764359 chr7:65958608 NA 0.67 14.96 0.51 1.34e-43 Aortic root size; BRCA cis rs7524258 0.868 rs4908610 chr1:7311260 C/A cg07173049 chr1:7289937 CAMTA1 0.42 10.34 0.38 2.9e-23 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs2153535 0.580 rs9505448 chr6:8459804 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.6 -12.71 -0.45 3.81e-33 Lymphocyte counts; BRCA cis rs875971 0.658 rs432667 chr7:65514633 A/G cg12463550 chr7:65579703 CRCP 0.37 7.92 0.3 1.02e-14 Aortic root size; BRCA trans rs75804782 0.521 rs72993056 chr2:239404671 G/T cg01134436 chr17:81009848 B3GNTL1 0.67 8.56 0.32 8.1e-17 Morning vs. evening chronotype;Chronotype; BRCA trans rs7615952 0.515 rs4441610 chr3:125681307 C/G cg07211511 chr3:129823064 LOC729375 -0.6 -11.19 -0.4 1.11e-26 Blood pressure (smoking interaction); BRCA cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.59 -14.13 -0.49 1.23e-39 Colorectal cancer; BRCA cis rs637571 0.510 rs3892696 chr11:65582341 G/C cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -8.79 -0.33 1.37e-17 Eosinophil percentage of white cells; BRCA cis rs7561273 0.609 rs1056122 chr2:24342505 C/T cg04809136 chr2:24300158 SF3B14 0.4 8.84 0.33 9.07e-18 Quantitative traits; BRCA trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs523522 0.673 rs643372 chr12:121022640 C/G cg12219531 chr12:120966889 COQ5 0.55 11.68 0.42 1.06e-28 High light scatter reticulocyte count; BRCA cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg18479299 chr3:125709523 NA -0.54 -8.36 -0.31 4.05e-16 Blood pressure (smoking interaction); BRCA trans rs1459104 1.000 rs34382934 chr11:55315256 C/T cg15704280 chr7:45808275 SEPT13 0.63 7.91 0.3 1.13e-14 Body mass index; BRCA cis rs2625529 0.761 rs11853268 chr15:72238973 T/C cg16672083 chr15:72433130 SENP8 -0.84 -17.52 -0.57 2.13e-56 Red blood cell count; BRCA trans rs9650657 0.589 rs6985109 chr8:10761585 A/G cg15556689 chr8:8085844 FLJ10661 0.36 9.57 0.35 2.28e-20 Neuroticism; BRCA cis rs2016266 1.000 rs10783573 chr12:53728369 G/A cg26875137 chr12:53738046 NA 0.4 10.56 0.39 3.91e-24 Bone mineral density (spine);Bone mineral density; BRCA cis rs6740322 1.000 rs4128209 chr2:43554729 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -12.14 -0.43 1.13e-30 Coronary artery disease; BRCA cis rs911119 0.909 rs111360484 chr20:23618984 G/C cg16589663 chr20:23618590 CST3 0.47 8.84 0.33 9.27e-18 Chronic kidney disease; BRCA cis rs66530629 1.000 rs16829945 chr1:25040315 C/T cg01905478 chr1:25040257 NA 0.38 8.91 0.33 5.28e-18 Plateletcrit; BRCA cis rs2066819 1.000 rs117683816 chr12:56638267 T/C cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs9435341 0.826 rs17496332 chr1:107546375 C/T cg09367891 chr1:107599246 PRMT6 -0.47 -8.66 -0.32 3.81e-17 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -8.41 -0.32 2.69e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs1372520 0.684 rs2737030 chr4:90710099 C/T cg15133208 chr4:90757351 SNCA -0.4 -7.91 -0.3 1.15e-14 Neuroticism; BRCA cis rs367943 0.608 rs7705084 chr5:112990748 G/A cg12552261 chr5:112820674 MCC 0.36 7.84 0.3 1.91e-14 Type 2 diabetes; BRCA cis rs2742234 0.614 rs3026750 chr10:43607756 G/A cg15436174 chr10:43711423 RASGEF1A -0.4 -8.49 -0.32 1.44e-16 Hirschsprung disease; BRCA cis rs208346 0.612 rs208356 chr7:2775825 A/T cg19717773 chr7:2847554 GNA12 0.54 11.57 0.42 3e-28 Loneliness (linear analysis); BRCA cis rs9487051 0.735 rs419106 chr6:109520067 C/G cg21918786 chr6:109611834 NA -0.36 -9.69 -0.36 8.06e-21 Reticulocyte fraction of red cells; BRCA cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg13010199 chr12:38710504 ALG10B 0.44 9.32 0.35 1.88e-19 Bladder cancer; BRCA cis rs9560113 0.806 rs9560112 chr13:112183320 A/G cg10483660 chr13:112241077 NA 0.32 8.13 0.31 2.26e-15 Menarche (age at onset); BRCA cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.03 0.4 5e-26 Rheumatoid arthritis; BRCA cis rs77972916 0.505 rs6753197 chr2:43527962 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -11.35 -0.41 2.56e-27 Granulocyte percentage of myeloid white cells; BRCA cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg27347728 chr4:17578864 LAP3 -0.43 -8.22 -0.31 1.16e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg12365402 chr11:9010492 NRIP3 -0.42 -9.34 -0.35 1.6e-19 Hemoglobin concentration; BRCA cis rs4363385 0.747 rs7529110 chr1:152966247 A/C cg21543102 chr1:152974771 SPRR3 -0.3 -8.64 -0.32 4.51e-17 Inflammatory skin disease; BRCA trans rs208520 0.690 rs1318604 chr6:66825278 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.79 -0.64 1.07e-73 Exhaled nitric oxide output; BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.17 -0.43 8.62e-31 Alzheimer's disease; BRCA cis rs68170813 0.559 rs4515482 chr7:107072681 A/C cg02696742 chr7:106810147 HBP1 -0.46 -8.18 -0.31 1.58e-15 Coronary artery disease; BRCA cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg06618935 chr21:46677482 NA -0.38 -8.39 -0.32 3.11e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9287719 0.967 rs6759100 chr2:10746710 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs514406 0.929 rs554301 chr1:53321948 A/T cg27535305 chr1:53392650 SCP2 0.36 8.97 0.33 3.17e-18 Monocyte count; BRCA cis rs1864400 0.645 rs2249005 chr10:43627280 A/G cg15436174 chr10:43711423 RASGEF1A -0.55 -10.96 -0.4 9.53e-26 Hirschsprung disease; BRCA trans rs6952808 0.756 rs4719311 chr7:1881813 C/T cg04565464 chr8:145669602 NFKBIL2 0.36 8.22 0.31 1.12e-15 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg13319975 chr6:146136371 FBXO30 -0.44 -10.15 -0.37 1.47e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs7493 1.000 rs12026 chr7:95041016 G/C cg17330251 chr7:94953956 PON1 -0.42 -8.9 -0.33 5.76e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg00012203 chr2:219082015 ARPC2 -0.48 -9.27 -0.34 2.92e-19 Colorectal cancer; BRCA cis rs4908768 0.501 rs11121194 chr1:8569906 C/T cg20416874 chr1:8611966 RERE -0.28 -8.22 -0.31 1.12e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2011503 0.739 rs4808973 chr19:19725456 A/G cg11584989 chr19:19387371 SF4 -0.44 -9.35 -0.35 1.51e-19 Bipolar disorder; BRCA trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.37 8.51 0.32 1.23e-16 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg06046430 chr4:77819534 ANKRD56 0.61 13.63 0.47 2.57e-37 Emphysema distribution in smoking; BRCA cis rs8016982 0.632 rs7142641 chr14:81677454 A/G cg01989461 chr14:81687754 GTF2A1 0.48 8.61 0.32 5.73e-17 Schizophrenia; BRCA cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg22535103 chr8:58192502 C8orf71 -0.54 -11.76 -0.42 4.75e-29 Developmental language disorder (linguistic errors); BRCA cis rs7100689 0.622 rs1417221 chr10:82100428 G/A cg00277334 chr10:82204260 NA -0.44 -8.66 -0.32 3.75e-17 Post bronchodilator FEV1; BRCA cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.95 -0.3 8.23e-15 Ulcerative colitis; BRCA cis rs4819052 0.565 rs35776291 chr21:46706142 T/C cg11663144 chr21:46675770 NA -0.47 -11.15 -0.4 1.69e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9790314 0.747 rs9990242 chr3:160838461 T/C cg03342759 chr3:160939853 NMD3 -0.53 -10.32 -0.38 3.44e-23 Morning vs. evening chronotype; BRCA cis rs6546886 0.912 rs10200470 chr2:74284687 A/G cg14702570 chr2:74259524 NA -0.32 -8.01 -0.3 5.29e-15 Dialysis-related mortality; BRCA cis rs77633900 0.614 rs280005 chr15:77009185 G/C cg21673338 chr15:77095150 SCAPER -0.54 -9.85 -0.36 2.03e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.52 0.5 1.73e-41 Motion sickness; BRCA cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.63 0.53 7.54e-47 Colorectal cancer; BRCA cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg05623727 chr3:50126028 RBM5 -0.49 -12.16 -0.43 9.5e-31 Body mass index; BRCA cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 11.88 0.43 1.44e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs7474896 0.559 rs1208645 chr10:38132087 C/T cg25427524 chr10:38739819 LOC399744 0.57 10.33 0.38 3.2e-23 Obesity (extreme); BRCA cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg07493874 chr5:1342172 CLPTM1L -0.5 -14.22 -0.49 4.46e-40 Lung cancer; BRCA trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.67 0.55 4.32e-52 Morning vs. evening chronotype; BRCA cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg19622623 chr12:86230825 RASSF9 -0.28 -7.91 -0.3 1.14e-14 Major depressive disorder; BRCA cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -9.4 -0.35 9.85e-20 Schizophrenia; BRCA cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg18402987 chr7:1209562 NA 0.8 8.61 0.32 5.54e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs4650994 0.544 rs4075631 chr1:178506594 C/A cg05059571 chr16:84539110 KIAA1609 -0.5 -11.14 -0.4 1.75e-26 HDL cholesterol levels;HDL cholesterol; BRCA cis rs8177179 0.967 rs9820225 chr3:133449189 A/G cg24879335 chr3:133465180 TF 0.33 11.07 0.4 3.48e-26 Iron status biomarkers (transferrin levels); BRCA cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg26384229 chr12:38710491 ALG10B -0.58 -13.43 -0.47 2.13e-36 Morning vs. evening chronotype; BRCA cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg00484396 chr16:3507460 NAT15 0.43 9.07 0.34 1.42e-18 Tuberculosis; BRCA cis rs796364 0.806 rs10931890 chr2:201102055 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -8.43 -0.32 2.29e-16 Schizophrenia; BRCA cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.81e-18 Bone mineral density; BRCA cis rs2455601 0.786 rs3763914 chr11:8940703 G/T cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -8.94 -0.33 4.19e-18 Schizophrenia; BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg04166393 chr7:2884313 GNA12 -0.62 -12.74 -0.45 2.66e-33 Height; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg18765753 chr7:1198926 ZFAND2A -0.47 -11.37 -0.41 2.14e-27 Longevity;Endometriosis; BRCA cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg24558204 chr6:135376177 HBS1L 0.59 15.89 0.53 3.8e-48 High light scatter reticulocyte percentage of red cells; BRCA cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg06221963 chr1:154839813 KCNN3 -0.59 -16.35 -0.54 1.85e-50 Prostate cancer; BRCA cis rs78456975 0.739 rs11891867 chr2:1517894 C/T cg26248373 chr2:1572462 NA -0.53 -10.89 -0.4 1.82e-25 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs654950 0.783 rs640688 chr1:42001831 A/G cg06885757 chr1:42089581 HIVEP3 -0.23 -8.41 -0.32 2.77e-16 Airway imaging phenotypes; BRCA cis rs1577917 1.000 rs12190604 chr6:86716215 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -7.97 -0.3 7.18e-15 Response to antipsychotic treatment; BRCA cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.39e-32 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.586 rs11710916 chr3:161130070 A/G cg04691961 chr3:161091175 C3orf57 -0.39 -9.02 -0.34 2.24e-18 Morning vs. evening chronotype; BRCA cis rs17376456 1.000 rs9968691 chr5:93509756 C/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 7.98 0.3 6.81e-15 Diabetic retinopathy; BRCA cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.13 0.37 1.86e-22 Bipolar disorder; BRCA trans rs2204008 0.754 rs11181244 chr12:38302454 T/C cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Bladder cancer; BRCA cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg17366294 chr4:99064904 C4orf37 0.52 11.61 0.42 2.09e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs9470366 0.527 rs10807170 chr6:36629444 C/T cg08179530 chr6:36648295 CDKN1A -0.52 -11.45 -0.41 9.28e-28 QRS duration; BRCA cis rs4631830 0.695 rs11004584 chr10:51500088 G/T cg16070123 chr10:51489643 NA -0.35 -7.81 -0.3 2.31e-14 Prostate-specific antigen levels; BRCA cis rs6570726 0.533 rs1832374 chr6:145717752 A/G cg23711669 chr6:146136114 FBXO30 0.44 8.83 0.33 9.67e-18 Lobe attachment (rater-scored or self-reported); BRCA trans rs9325144 0.555 rs1825806 chr12:38692547 G/A cg23762105 chr12:34175262 ALG10 -0.4 -9.81 -0.36 2.96e-21 Morning vs. evening chronotype; BRCA cis rs6598955 0.671 rs17163746 chr1:26564230 C/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA trans rs8002861 0.905 rs80209017 chr13:44473182 T/C cg17145862 chr1:211918768 LPGAT1 0.7 18.22 0.58 4.67e-60 Leprosy; BRCA cis rs8023845 0.954 rs1680156 chr15:40447265 T/C cg20259534 chr15:40453036 BUB1B 0.5 8.01 0.3 5.54e-15 Chronic lymphocytic leukemia; BRCA cis rs853679 0.517 rs9393890 chr6:28063855 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.2 -0.31 1.28e-15 Depression; BRCA cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg02780029 chr10:43622663 RET 0.35 7.91 0.3 1.14e-14 Hirschsprung disease; BRCA cis rs10504073 0.647 rs9643394 chr8:50014427 A/G cg00325661 chr8:49890786 NA 0.38 11.32 0.41 3.24e-27 Blood metabolite ratios; BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg19346786 chr7:2764209 NA -0.34 -9.7 -0.36 7.84e-21 Height; BRCA cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg21770322 chr7:97807741 LMTK2 0.43 11.43 0.41 1.13e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs12210905 0.688 rs78285097 chr6:27374644 G/C cg08851530 chr6:28072375 NA 0.84 8.2 0.31 1.36e-15 Hip circumference adjusted for BMI; BRCA cis rs2617583 0.967 rs2550946 chr5:1450513 A/G cg07151155 chr5:1473589 LPCAT1 -0.42 -9.12 -0.34 9.53e-19 Breast cancer; BRCA cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg17724175 chr1:150552817 MCL1 0.31 9.97 0.37 7.42e-22 Urate levels; BRCA cis rs12760731 0.720 rs10798607 chr1:178373110 C/T cg00404053 chr1:178313656 RASAL2 0.7 8.36 0.31 3.81e-16 Obesity-related traits; BRCA cis rs6964587 0.626 rs7785941 chr7:91531024 T/C cg17063962 chr7:91808500 NA -0.55 -12.67 -0.45 5.41e-33 Breast cancer; BRCA cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg00857998 chr1:205179979 DSTYK 0.41 8.05 0.3 3.94e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.48 -0.35 4.74e-20 Alzheimer's disease (late onset); BRCA cis rs3008870 1.000 rs2755250 chr1:67495283 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.93 20.7 0.63 3.04e-73 Lymphocyte percentage of white cells; BRCA cis rs116095464 0.558 rs7356535 chr5:284117 G/T cg22496380 chr5:211416 CCDC127 -1.0 -14.08 -0.49 1.99e-39 Breast cancer; BRCA cis rs12545109 0.671 rs35500854 chr8:57424303 G/A cg09654669 chr8:57350985 NA -0.42 -8.01 -0.3 5.62e-15 Obesity-related traits; BRCA cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg01236616 chr12:121019343 POP5 1.24 27.85 0.74 2.17e-112 Type 1 diabetes nephropathy; BRCA cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg11764359 chr7:65958608 NA 0.77 17.36 0.57 1.4e-55 Aortic root size; BRCA cis rs7618501 0.521 rs34654589 chr3:49911449 C/G cg24110177 chr3:50126178 RBM5 -0.51 -14.23 -0.49 4.24e-40 Intelligence (multi-trait analysis); BRCA cis rs6089584 0.546 rs6061978 chr20:60615604 C/T cg06108461 chr20:60628389 TAF4 -0.68 -14.3 -0.49 1.93e-40 Body mass index; BRCA cis rs858239 1.000 rs199357 chr7:23288309 A/G cg23682824 chr7:23144976 KLHL7 -0.34 -8.43 -0.32 2.3e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11890956 chr21:40555474 PSMG1 -0.95 -24.07 -0.69 1.23e-91 Cognitive function; BRCA cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs9473147 0.543 rs7738044 chr6:47469273 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.93e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg04709771 chr16:646395 RAB40C 0.45 11.25 0.41 6.76e-27 Height; BRCA cis rs13256369 0.760 rs7816171 chr8:8575835 T/C cg00074818 chr8:8560427 CLDN23 0.38 8.31 0.31 5.64e-16 Obesity-related traits; BRCA cis rs2836974 0.545 rs3167757 chr21:40714478 C/T cg11644478 chr21:40555479 PSMG1 0.53 11.53 0.42 4.44e-28 Cognitive function; BRCA trans rs9325144 0.554 rs1906264 chr12:38739490 A/G cg23762105 chr12:34175262 ALG10 -0.37 -9.21 -0.34 4.72e-19 Morning vs. evening chronotype; BRCA cis rs910316 0.737 rs175499 chr14:75535927 G/A cg23033748 chr14:75592666 NEK9 -0.34 -7.99 -0.3 6.45e-15 Height; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.6 -0.32 6.14e-17 Total body bone mineral density; BRCA cis rs66530629 0.917 rs11249178 chr1:25171719 G/C cg01905478 chr1:25040257 NA 0.34 7.88 0.3 1.4e-14 Plateletcrit; BRCA cis rs11098499 0.909 rs2127821 chr4:120394535 T/C cg09307838 chr4:120376055 NA 0.75 16.07 0.54 4.89e-49 Corneal astigmatism; BRCA cis rs1451375 0.755 rs6969081 chr7:50624505 A/T cg18232548 chr7:50535776 DDC 0.44 11.09 0.4 2.89e-26 Malaria; BRCA cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg24112000 chr20:60950667 NA 0.5 9.92 0.37 1.14e-21 Colorectal cancer; BRCA cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg16680214 chr1:154839983 KCNN3 0.44 11.75 0.42 5.18e-29 Prostate cancer; BRCA cis rs586533 0.813 rs11220769 chr11:99507548 G/C cg22878054 chr11:99397252 CNTN5 0.31 7.85 0.3 1.79e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs4820294 0.669 rs7287358 chr22:38054403 A/G cg21798802 chr22:38057573 PDXP 0.29 7.9 0.3 1.23e-14 Fat distribution (HIV); BRCA cis rs2130392 1.000 rs11132254 chr4:185611592 G/T cg21366198 chr4:185655624 MLF1IP -0.42 -9.95 -0.37 8.75e-22 Kawasaki disease; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg08045932 chr20:61659980 NA 0.49 11.35 0.41 2.57e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg23306229 chr2:178417860 TTC30B 0.47 7.82 0.3 2.19e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs60843830 1.000 rs7566279 chr2:281178 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 14.17 0.49 7.77e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg03188948 chr7:1209495 NA 0.53 9.17 0.34 6.4e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg09184832 chr6:79620586 NA -0.5 -11.04 -0.4 4.74e-26 Intelligence (multi-trait analysis); BRCA cis rs6878727 0.545 rs2591383 chr5:123687171 G/A cg01806427 chr5:123737813 NA -0.37 -8.23 -0.31 1.07e-15 Breast cancer; BRCA cis rs10421328 0.848 rs867616 chr19:19757682 C/T cg11584989 chr19:19387371 SF4 0.41 8.1 0.31 2.75e-15 Parental longevity (combined parental age at death); BRCA cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg01262667 chr19:19385393 TM6SF2 -0.41 -10.6 -0.39 2.64e-24 Tonsillectomy; BRCA cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs7560272 0.538 rs12052539 chr2:73937153 C/T cg20560298 chr2:73613845 ALMS1 -0.34 -8.97 -0.33 3.23e-18 Schizophrenia; BRCA cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg10802521 chr3:52805072 NEK4 -0.32 -8.26 -0.31 8.46e-16 Bipolar disorder; BRCA cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg24450063 chr1:156163899 SLC25A44 1.12 36.14 0.82 1.26e-156 Testicular germ cell tumor; BRCA cis rs11098499 0.690 rs34818745 chr4:120257055 T/C cg09307838 chr4:120376055 NA 0.7 14.87 0.51 3.55e-43 Corneal astigmatism; BRCA trans rs208520 0.690 rs207108 chr6:66794096 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg22638593 chr5:131593259 PDLIM4 0.32 7.86 0.3 1.7e-14 Acylcarnitine levels; BRCA cis rs10045504 0.502 rs17456635 chr5:38745456 G/A cg15396434 chr5:38725168 NA -0.57 -10.76 -0.39 6.11e-25 Night sleep phenotypes; BRCA cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg15103426 chr22:29168792 CCDC117 -0.54 -12.57 -0.45 1.48e-32 Lymphocyte counts; BRCA cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg13271783 chr10:134563150 INPP5A -0.51 -9.59 -0.35 1.99e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1003719 0.762 rs8130846 chr21:38480242 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.16 0.49 8.34e-40 Eye color traits; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.63 -12.81 -0.45 1.31e-33 Lymphocyte counts; BRCA cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg24558204 chr6:135376177 HBS1L 0.57 15.5 0.52 3.25e-46 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg15103426 chr22:29168792 CCDC117 0.51 12.15 0.43 1.06e-30 Lymphocyte counts; BRCA cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg15145296 chr3:125709740 NA -0.54 -8.68 -0.32 3.28e-17 Blood pressure (smoking interaction); BRCA cis rs34779708 0.966 rs2505639 chr10:35474421 A/G cg03585969 chr10:35415529 CREM -0.47 -9.96 -0.37 8.26e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs826838 0.967 rs826876 chr12:39123843 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.05 -0.54 5.71e-49 Heart rate; BRCA cis rs9287719 0.967 rs7355649 chr2:10748094 C/A cg00105475 chr2:10696890 NA 0.44 10.13 0.37 1.88e-22 Prostate cancer; BRCA cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg07636037 chr3:49044803 WDR6 0.97 28.35 0.75 4.41e-115 Parkinson's disease; BRCA cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg18132916 chr6:79620363 NA -0.41 -8.27 -0.31 7.84e-16 Intelligence (multi-trait analysis); BRCA cis rs11585357 0.895 rs72633812 chr1:17623140 T/C cg08277548 chr1:17600880 PADI3 -0.75 -12.35 -0.44 1.43e-31 Hair shape; BRCA trans rs1478897 0.898 rs2248932 chr8:11391650 A/G cg15556689 chr8:8085844 FLJ10661 -0.33 -8.52 -0.32 1.13e-16 Systemic lupus erythematosus; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.66 -13.42 -0.47 2.48e-36 Lymphocyte counts; BRCA trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.97 0.3 7.33e-15 Corneal astigmatism; BRCA cis rs6582630 0.533 rs11504406 chr12:38334580 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.58 -0.35 2.19e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs1475911 1.000 rs2839467 chr21:43513200 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.46 9.39 0.35 1.03e-19 IgG glycosylation; BRCA cis rs113835537 0.529 rs11821155 chr11:66246337 C/T cg24851651 chr11:66362959 CCS -0.42 -7.96 -0.3 7.81e-15 Airway imaging phenotypes; BRCA cis rs12210905 0.614 rs12199685 chr6:27323486 G/A cg08851530 chr6:28072375 NA 0.91 8.7 0.33 2.7e-17 Hip circumference adjusted for BMI; BRCA trans rs3749237 1.000 rs2291542 chr3:49751585 C/T cg21659725 chr3:3221576 CRBN 0.52 12.31 0.44 2.19e-31 Resting heart rate; BRCA cis rs1878931 0.580 rs7194596 chr16:3404408 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.81 19.15 0.6 5.85e-65 Body mass index (adult); BRCA cis rs7715811 1.000 rs1502052 chr5:13774908 G/A cg07548982 chr5:13769939 DNAH5 -0.4 -9.0 -0.34 2.62e-18 Subclinical atherosclerosis traits (other); BRCA cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg15017067 chr4:17643749 FAM184B 0.32 9.82 0.36 2.75e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2197308 0.765 rs2387436 chr12:37935337 C/T cg06521331 chr12:34319734 NA 0.44 8.49 0.32 1.44e-16 Morning vs. evening chronotype; BRCA cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg03433033 chr1:76189801 ACADM 0.69 16.99 0.56 1.04e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17253792 0.822 rs79618862 chr14:56093971 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.6e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs16958440 0.867 rs75901436 chr18:44689644 C/T cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs11039389 1 rs11039389 chr11:47796062 T/C cg18512352 chr11:47633146 NA -0.34 -8.3 -0.31 6.28e-16 Neuroticism; BRCA cis rs2742234 0.955 rs2503841 chr10:43675721 C/T cg15436174 chr10:43711423 RASGEF1A -0.41 -8.73 -0.33 2.24e-17 Hirschsprung disease; BRCA cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg24549020 chr5:56110836 MAP3K1 0.59 11.92 0.43 9.99e-30 Initial pursuit acceleration; BRCA cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg06064525 chr11:970664 AP2A2 -0.49 -16.22 -0.54 7.89e-50 Alzheimer's disease (late onset); BRCA cis rs795544 0.608 rs1502048 chr5:13788282 C/T cg07548982 chr5:13769939 DNAH5 0.38 8.26 0.31 8.48e-16 Corneal astigmatism; BRCA cis rs4988958 0.527 rs6756161 chr2:103048417 C/A cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma (childhood onset); BRCA cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg14530993 chr4:882597 GAK 0.59 9.68 0.36 9.2e-21 Intelligence (multi-trait analysis); BRCA cis rs912057 0.833 rs1024245 chr6:6743319 A/G cg06612196 chr6:6737390 NA 0.4 8.86 0.33 7.98e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.99 0.3 6.41e-15 Depression; BRCA cis rs4689388 0.890 rs13130845 chr4:6297646 A/C cg00701064 chr4:6280414 WFS1 0.7 18.2 0.58 5.6899999999999994e-60 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.39e-15 Menopause (age at onset); BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg00106254 chr7:1943704 MAD1L1 -0.4 -10.76 -0.39 6.08e-25 Bipolar disorder and schizophrenia; BRCA cis rs2014572 0.967 rs10411941 chr19:57762886 C/T cg24459738 chr19:57751996 ZNF805 -0.37 -8.71 -0.33 2.59e-17 Hyperactive-impulsive symptoms; BRCA cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg02297831 chr4:17616191 MED28 -0.35 -7.99 -0.3 6.33e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg04511125 chr2:88470314 THNSL2 0.79 11.38 0.41 1.8e-27 Plasma clusterin levels; BRCA cis rs72772090 0.522 rs113433514 chr5:95995022 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -8.5 -0.32 1.3e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17401966 0.931 rs17034821 chr1:10414645 A/G cg03954927 chr1:10346856 KIF1B 0.48 14.87 0.51 3.63e-43 Hepatocellular carcinoma; BRCA cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg17366294 chr4:99064904 C4orf37 0.54 11.6 0.42 2.2e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs1834645 chr4:98979593 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.13e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -13.04 -0.46 1.28e-34 Schizophrenia; BRCA trans rs3733585 0.605 rs4697926 chr4:10124567 G/T cg26043149 chr18:55253948 FECH 0.37 7.84 0.3 1.85e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2251381 0.523 rs2832306 chr21:30754468 C/T cg08807101 chr21:30365312 RNF160 -0.38 -8.13 -0.31 2.21e-15 Selective IgA deficiency; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -8.54 -0.32 9.82e-17 Longevity;Endometriosis; BRCA cis rs7254827 0.737 rs35005380 chr19:17158056 G/A cg19418318 chr19:17219073 MYO9B -0.48 -10.17 -0.37 1.29e-22 Mean platelet volume; BRCA cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 15.63 0.53 6.83e-47 Colorectal cancer; BRCA cis rs11971779 0.648 rs6947309 chr7:139035830 C/T cg07862535 chr7:139043722 LUC7L2 0.35 9.28 0.34 2.56e-19 Diisocyanate-induced asthma; BRCA cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg24324837 chr19:49891574 CCDC155 0.51 9.05 0.34 1.68e-18 Multiple sclerosis; BRCA cis rs3784262 0.669 rs4646580 chr15:58329211 A/G cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.87 -0.36 1.78e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4332037 0.510 rs11762803 chr7:1886805 A/G cg23422044 chr7:1970798 MAD1L1 -0.47 -9.76 -0.36 4.36e-21 Bipolar disorder; BRCA trans rs6952808 0.964 rs10950400 chr7:1882470 C/T cg04565464 chr8:145669602 NFKBIL2 0.38 8.36 0.31 4.02e-16 Bipolar disorder and schizophrenia; BRCA cis rs1008375 1.000 rs3733579 chr4:17694943 A/G cg02297831 chr4:17616191 MED28 0.36 8.42 0.32 2.41e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg02353165 chr6:42928485 GNMT 0.54 9.49 0.35 4.61e-20 Blood protein levels; BRCA cis rs911119 1.000 rs13039536 chr20:23612305 A/G cg16589663 chr20:23618590 CST3 0.46 8.72 0.33 2.32e-17 Chronic kidney disease; BRCA cis rs10206020 0.921 rs9678719 chr2:1549628 A/G cg26248373 chr2:1572462 NA -0.53 -11.61 -0.42 1.98e-28 IgG glycosylation; BRCA cis rs7267979 1.000 rs910997 chr20:25267301 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.84 0.36 2.26e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2658782 0.547 rs3020054 chr11:93055556 C/T cg15737290 chr11:93063684 CCDC67 0.57 13.87 0.48 1.91e-38 Pulmonary function decline; BRCA trans rs853679 0.607 rs67340775 chr6:28304384 A/C cg01620082 chr3:125678407 NA -0.85 -10.01 -0.37 5.21e-22 Depression; BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg09877947 chr5:131593287 PDLIM4 0.42 10.73 0.39 8.24e-25 Breast cancer; BRCA cis rs1003719 0.715 rs2835613 chr21:38496883 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.24 -0.49 3.83e-40 Eye color traits; BRCA cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg14403583 chr14:105418241 AHNAK2 -0.38 -8.98 -0.33 3.12e-18 Rheumatoid arthritis; BRCA cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg07741184 chr6:167504864 NA -0.29 -8.51 -0.32 1.21e-16 Crohn's disease; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg27588902 chr6:42928151 GNMT -0.31 -10.16 -0.37 1.43e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg11062466 chr8:58055876 NA -0.52 -9.08 -0.34 1.37e-18 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg11644478 chr21:40555479 PSMG1 -0.54 -11.53 -0.42 4.39e-28 Menarche (age at onset); BRCA cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg20916646 chr4:852691 GAK 0.37 9.09 0.34 1.27e-18 Sjögren's syndrome; BRCA cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg15485101 chr11:133734466 NA 0.4 9.77 0.36 4.32e-21 Childhood ear infection; BRCA cis rs6733011 0.508 rs4850889 chr2:99521385 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.25 -0.34 3.45e-19 Bipolar disorder; BRCA cis rs13046373 0.535 rs2832970 chr21:32020767 T/C cg06468780 chr21:31798236 KRTAP13-3 0.33 8.37 0.31 3.62e-16 HDL cholesterol; BRCA cis rs2745967 0.740 rs2785645 chr1:208067420 A/G cg09788693 chr1:208063733 CD34 0.37 7.84 0.3 1.86e-14 Resting heart rate; BRCA cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg07828340 chr4:882639 GAK -0.97 -12.4 -0.44 8.43e-32 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg13319975 chr6:146136371 FBXO30 -0.54 -12.08 -0.43 2.06e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs6750795 0.542 rs1797388 chr2:232415981 T/G cg19187155 chr2:232395269 NMUR1 0.69 17.45 0.57 4.92e-56 Height; BRCA cis rs9790314 0.846 rs4290817 chr3:160967354 G/A cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.09e-59 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs6050609 chr20:25411751 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.25 -0.34 3.46e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs754466 0.606 rs11002308 chr10:79594796 A/T cg17075019 chr10:79541650 NA -0.81 -20.56 -0.63 1.76e-72 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg02659138 chr7:134003124 SLC35B4 0.34 10.47 0.38 8.74e-24 Mean platelet volume; BRCA cis rs17270561 0.609 rs17267614 chr6:25730027 A/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.64 0.32 4.67e-17 Iron status biomarkers; BRCA cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg24549020 chr5:56110836 MAP3K1 0.62 10.47 0.38 8.45e-24 Type 2 diabetes; BRCA cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg26597838 chr10:835615 NA -0.64 -13.07 -0.46 8.77e-35 Eosinophil percentage of granulocytes; BRCA trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg26384229 chr12:38710491 ALG10B 0.75 16.63 0.55 7.23e-52 Morning vs. evening chronotype; BRCA cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg07917127 chr4:99064746 C4orf37 0.41 7.85 0.3 1.7e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs3857067 0.806 rs9996975 chr4:95101338 C/G cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.36 -0.35 1.31e-19 QT interval; BRCA cis rs61931739 0.500 rs7312938 chr12:34378708 C/T cg06521331 chr12:34319734 NA -0.56 -10.01 -0.37 5.22e-22 Morning vs. evening chronotype; BRCA cis rs7582180 0.629 rs10202326 chr2:100950237 A/G cg14675211 chr2:100938903 LONRF2 0.44 10.11 0.37 2.18e-22 Intelligence (multi-trait analysis); BRCA cis rs9837602 0.935 rs17392948 chr3:99754498 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.61 10.53 0.38 5.24e-24 Breast cancer; BRCA cis rs8072100 0.713 rs8074451 chr17:45477573 C/T cg25173405 chr17:45401733 C17orf57 -0.53 -10.94 -0.4 1.24e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs8180040 0.966 rs59586735 chr3:47518325 C/T cg27129171 chr3:47204927 SETD2 -0.68 -16.05 -0.54 5.93e-49 Colorectal cancer; BRCA cis rs4730250 0.707 rs6977868 chr7:106790555 T/G cg02696742 chr7:106810147 HBP1 0.61 9.52 0.35 3.54e-20 Osteoarthritis; BRCA cis rs1034435 0.723 rs713946 chr22:48891376 T/C cg05992904 chr22:48892994 FAM19A5 -0.79 -20.42 -0.63 1.04e-71 Late-onset Alzheimer's disease; BRCA cis rs9473147 0.543 rs4715019 chr6:47447041 T/A cg12968598 chr6:47444699 CD2AP 0.45 9.69 0.36 8.52e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs858239 0.539 rs6971673 chr7:23159523 C/G cg23682824 chr7:23144976 KLHL7 0.42 11.09 0.4 2.96e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs6450176 0.909 rs3776721 chr5:53292522 A/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.11 -0.49 1.51e-39 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7818345 0.967 rs11204040 chr8:19288525 T/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.97 0.3 7.15e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg12386194 chr3:101231763 SENP7 0.46 9.81 0.36 2.87e-21 Colorectal cancer; BRCA cis rs2430307 0.556 rs3905501 chr7:76542080 C/T cg15770687 chr7:76625569 PMS2L11 -0.54 -9.51 -0.35 3.96e-20 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg17366294 chr4:99064904 C4orf37 0.51 11.46 0.41 8.52e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs7264396 0.790 rs11697903 chr20:34272224 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 7.97 0.3 7.13e-15 Total cholesterol levels; BRCA cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2014572 0.967 rs10427146 chr19:57755998 T/C cg24459738 chr19:57751996 ZNF805 -0.33 -7.98 -0.3 6.85e-15 Hyperactive-impulsive symptoms; BRCA cis rs10044254 0.614 rs11750054 chr5:15733602 T/C cg07238450 chr5:15720153 FBXL7 -0.37 -7.94 -0.3 9.34e-15 Asthma (corticosteroid response); BRCA cis rs12617721 0.645 rs114544871 chr2:99045485 T/G cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg11644478 chr21:40555479 PSMG1 0.78 17.03 0.56 7.03e-54 Cognitive function; BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg10729496 chr3:10149963 C3orf24 0.49 9.14 0.34 8.18e-19 Alzheimer's disease; BRCA cis rs12579753 1.000 rs66646148 chr12:82248520 T/G cg07988820 chr12:82153109 PPFIA2 -0.56 -9.21 -0.34 4.59e-19 Resting heart rate; BRCA trans rs7618501 1.000 rs6785549 chr3:49736565 G/A cg21659725 chr3:3221576 CRBN -0.71 -21.87 -0.65 1.35e-79 Intelligence (multi-trait analysis); BRCA cis rs2422052 0.792 rs4849637 chr2:118645575 A/G cg22545206 chr2:118617499 NA 0.39 9.54 0.35 2.98e-20 Mosquito bite size; BRCA cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg08564027 chr20:61660810 NA 0.86 22.97 0.67 1.43e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs2204008 0.806 rs11520229 chr12:38246448 C/A cg13010199 chr12:38710504 ALG10B 0.5 9.89 0.36 1.54e-21 Bladder cancer; BRCA cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg24692254 chr21:30365293 RNF160 -0.48 -10.99 -0.4 7.54e-26 Cognitive test performance; BRCA cis rs7474896 0.515 rs662928 chr10:38316216 G/T cg25427524 chr10:38739819 LOC399744 0.51 9.44 0.35 6.74e-20 Obesity (extreme); BRCA cis rs6866344 0.697 rs17184344 chr5:178129281 A/G cg10224037 chr5:178157518 ZNF354A 0.76 15.97 0.53 1.55e-48 Neutrophil percentage of white cells; BRCA cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.78e-15 Breast cancer; BRCA cis rs1003719 0.680 rs2835621 chr21:38510616 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.32 -0.49 1.46e-40 Eye color traits; BRCA cis rs6815814 0.950 rs5743580 chr4:38804405 C/T cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs1505368 0.817 rs1283310 chr2:213273891 A/G cg20637307 chr2:213403960 ERBB4 0.39 9.09 0.34 1.24e-18 Symmetrical dimethylarginine levels; BRCA cis rs9788682 0.747 rs2656074 chr15:78741384 T/C cg24631222 chr15:78858424 CHRNA5 -0.48 -9.62 -0.36 1.56e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs365132 1.000 rs2292256 chr5:176333126 C/T cg16309518 chr5:176445507 NA -0.52 -13.45 -0.47 1.76e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2414095 0.527 rs8041967 chr15:51544324 G/A cg19946085 chr15:51559439 CYP19A1 -0.3 -7.82 -0.3 2.27e-14 Follicule stimulating hormone;Hormone measurements;Total body bone mineral density; BRCA cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg05623727 chr3:50126028 RBM5 -0.49 -12.16 -0.43 9.5e-31 Body mass index; BRCA cis rs11098499 0.955 rs11931312 chr4:120159023 T/C cg09307838 chr4:120376055 NA 0.61 12.3 0.44 2.34e-31 Corneal astigmatism; BRCA cis rs4595586 0.545 rs3914595 chr12:39388530 G/T cg26384229 chr12:38710491 ALG10B 0.42 9.44 0.35 6.82e-20 Morning vs. evening chronotype; BRCA cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.71e-15 Uric acid levels; BRCA cis rs757110 0.648 rs12146443 chr11:17384498 T/C cg15432903 chr11:17409602 KCNJ11 0.71 15.49 0.52 3.35e-46 Type 2 diabetes; BRCA cis rs7103648 0.695 rs7933019 chr11:47509137 G/C cg03711944 chr11:47377212 SPI1 -0.41 -9.84 -0.36 2.26e-21 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6893300 0.785 rs58386410 chr5:179205704 T/C cg14593053 chr5:179126677 CANX -0.36 -8.02 -0.3 4.9e-15 Resting heart rate; BRCA cis rs12579753 1.000 rs2400979 chr12:82197353 T/C cg07988820 chr12:82153109 PPFIA2 -0.6 -9.76 -0.36 4.55e-21 Resting heart rate; BRCA cis rs78487399 0.710 rs72881068 chr2:43690860 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.87 -0.3 1.56e-14 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs9914988 0.887 rs11650282 chr17:27090741 C/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.82 -0.33 1.08e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.76e-30 Corneal astigmatism; BRCA cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 11.29 0.41 4.31e-27 Alzheimer's disease; BRCA cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg21535247 chr6:8435926 SLC35B3 0.4 8.96 0.33 3.57e-18 Motion sickness; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg27170947 chr2:26402098 FAM59B 0.97 17.09 0.56 3.41e-54 Gut microbiome composition (summer); BRCA cis rs4481887 0.790 rs10888364 chr1:248488387 T/G cg00666640 chr1:248458726 OR2T12 0.3 8.58 0.32 7.32e-17 Common traits (Other); BRCA cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg00074818 chr8:8560427 CLDN23 0.39 8.54 0.32 1.02e-16 Obesity-related traits; BRCA cis rs3820928 1.000 rs10193404 chr2:227777757 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.48 -0.32 1.53e-16 Pulmonary function; BRCA cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg10845886 chr2:3471009 TTC15 -0.54 -12.22 -0.44 5.48e-31 Neurofibrillary tangles; BRCA cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg08885076 chr2:99613938 TSGA10 -0.52 -11.85 -0.42 1.95e-29 Chronic sinus infection; BRCA cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg02079420 chr8:82753780 SNX16 0.31 8.45 0.32 1.9e-16 Diastolic blood pressure; BRCA trans rs35110281 0.743 rs2329443 chr21:45059431 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 9.23 0.34 4.08e-19 Mean corpuscular volume; BRCA cis rs1401999 0.674 rs562 chr3:183637845 T/C cg01324343 chr3:183735012 ABCC5 0.65 15.67 0.53 4.3e-47 Anterior chamber depth; BRCA cis rs1832871 0.619 rs262823 chr6:158676149 G/C cg07215822 chr6:158701037 NA -0.49 -10.33 -0.38 3.06e-23 Height; BRCA cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.43 -9.75 -0.36 4.83e-21 Electroencephalogram traits; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg03188948 chr7:1209495 NA 0.92 14.25 0.49 3.13e-40 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg05234568 chr11:5960015 NA -0.46 -9.09 -0.34 1.2e-18 DNA methylation (variation); BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg04267008 chr7:1944627 MAD1L1 0.57 12.61 0.45 1.05e-32 Bipolar disorder and schizophrenia; BRCA cis rs10752881 1.000 rs10911190 chr1:182979080 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs7819412 0.540 rs11777355 chr8:11044689 A/G cg21775007 chr8:11205619 TDH -0.5 -10.07 -0.37 3.09e-22 Triglycerides; BRCA trans rs6089829 1.000 rs62207535 chr20:61669187 A/G cg15934090 chr1:100435551 SLC35A3 0.38 8.55 0.32 9.17e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs7980799 0.618 rs1482983 chr12:33690326 A/C cg26384229 chr12:38710491 ALG10B 0.53 11.29 0.41 4.33e-27 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs17209837 0.607 rs1558375 chr7:87079069 T/C cg00919237 chr7:87102261 ABCB4 -0.53 -10.22 -0.37 8.0700000000000006e-23 Gallbladder cancer; BRCA cis rs2629540 0.806 rs10901812 chr10:126419384 A/G cg08799069 chr10:126477246 METTL10 -0.44 -8.9 -0.33 5.82e-18 Cocaine dependence; BRCA cis rs11785693 0.862 rs11774099 chr8:4988218 C/T cg26367366 chr8:4980734 NA 0.61 11.04 0.4 4.75e-26 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.93 0.62 4.18e-69 Alzheimer's disease; BRCA cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg26248373 chr2:1572462 NA -0.67 -15.83 -0.53 7.21e-48 IgG glycosylation; BRCA cis rs12579753 0.917 rs11612874 chr12:82212649 A/C cg07988820 chr12:82153109 PPFIA2 0.5 8.55 0.32 9.12e-17 Resting heart rate; BRCA cis rs7301826 0.651 rs12228959 chr12:131296068 T/G cg11011512 chr12:131303247 STX2 0.52 13.65 0.48 2.18e-37 Plasma plasminogen activator levels; BRCA cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg17971929 chr21:40555470 PSMG1 0.53 11.81 0.42 2.93e-29 Cognitive function; BRCA cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.24e-41 Motion sickness; BRCA cis rs4588572 0.643 rs10043027 chr5:77792707 T/C cg11547950 chr5:77652471 NA -0.5 -8.98 -0.33 2.9e-18 Triglycerides; BRCA cis rs11971779 0.523 rs10279160 chr7:139090761 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.36 0.38 2.36e-23 Diisocyanate-induced asthma; BRCA cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs9837602 0.882 rs9875664 chr3:99729130 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 10.45 0.38 1.07e-23 Breast cancer; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg22638593 chr5:131593259 PDLIM4 0.32 7.86 0.3 1.7e-14 Acylcarnitine levels; BRCA cis rs1215050 0.791 rs1215049 chr4:98848280 C/T cg05340658 chr4:99064831 C4orf37 0.42 9.55 0.35 2.83e-20 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs701145 0.585 rs1713811 chr3:153874566 G/A cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.6e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.3 0.49 1.87e-40 Motion sickness; BRCA cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.44 -0.35 6.87e-20 Menopause (age at onset); BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg20607798 chr8:58055168 NA 0.63 9.54 0.35 2.86e-20 Developmental language disorder (linguistic errors); BRCA trans rs4714291 0.963 rs2395543 chr6:39965020 A/G cg02267698 chr19:7991119 CTXN1 0.43 8.47 0.32 1.64e-16 Strep throat; BRCA cis rs7246967 0.673 rs6511383 chr19:22956900 C/T cg23217946 chr19:22817039 ZNF492 0.5 9.06 0.34 1.58e-18 Bronchopulmonary dysplasia; BRCA cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg00074818 chr8:8560427 CLDN23 0.38 8.3 0.31 6.14e-16 Obesity-related traits; BRCA cis rs34172651 0.917 rs200539 chr16:24735178 T/C cg04756594 chr16:24857601 SLC5A11 -0.35 -8.42 -0.32 2.51e-16 Intelligence (multi-trait analysis); BRCA cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.56 -14.73 -0.5 1.64e-42 Colorectal cancer; BRCA cis rs265548 0.608 rs36690 chr19:17910483 C/T cg04517722 chr19:17905589 B3GNT3 0.43 8.45 0.32 1.92e-16 Tumor biomarkers; BRCA cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg14847009 chr1:175162515 KIAA0040 -0.26 -9.66 -0.36 1.03e-20 Alcohol dependence; BRCA cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg11663144 chr21:46675770 NA 0.6 13.87 0.48 2.01e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg14062083 chr21:31802829 KRTAP13-4 0.35 9.36 0.35 1.34e-19 HDL cholesterol; BRCA cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.09 0.49 1.8e-39 Colorectal cancer; BRCA cis rs35740288 0.721 rs4843093 chr15:86237433 G/A cg20737812 chr15:86336631 KLHL25 -0.32 -7.82 -0.3 2.22e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg08997352 chr12:9597637 DDX12 -0.5 -9.68 -0.36 8.83e-21 Breast size; BRCA cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg21573476 chr21:45109991 RRP1B -0.35 -9.01 -0.34 2.42e-18 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs4699601 chr4:99034429 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9858542 0.537 rs9818758 chr3:49382925 G/A cg00383909 chr3:49044727 WDR6 0.53 10.13 0.37 1.81e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs311392 0.966 rs404354 chr8:55087196 A/G cg11783602 chr8:55087084 NA -0.33 -9.59 -0.35 1.94e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg13902645 chr11:5959945 NA -0.55 -10.77 -0.39 5.53e-25 DNA methylation (variation); BRCA cis rs2191566 0.576 rs381091 chr19:44495315 G/A cg20607764 chr19:44506953 ZNF230 0.37 8.03 0.3 4.64e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs11025559 0.812 rs11025583 chr11:20513260 C/T cg19653624 chr11:20408972 PRMT3 0.41 9.81 0.36 3.01e-21 Pursuit maintenance gain; BRCA cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg23711669 chr6:146136114 FBXO30 0.78 18.61 0.59 4.47e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089584 0.627 rs35560719 chr20:60561917 A/C cg13770153 chr20:60521292 NA -0.4 -9.44 -0.35 6.84e-20 Body mass index; BRCA cis rs11025559 0.812 rs10766679 chr11:20509190 T/C cg19653624 chr11:20408972 PRMT3 -0.44 -10.41 -0.38 1.55e-23 Pursuit maintenance gain; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg18538332 chr22:24372958 LOC391322 0.53 12.75 0.45 2.4e-33 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg20933634 chr6:27740509 NA -0.43 -8.57 -0.32 7.65e-17 Parkinson's disease; BRCA cis rs10752881 0.775 rs2147585 chr1:183074875 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.43e-58 Colorectal cancer; BRCA cis rs7760949 0.925 rs9464420 chr6:13925892 C/T cg27413430 chr6:13925136 RNF182 0.45 9.06 0.34 1.57e-18 Mean corpuscular hemoglobin concentration; BRCA cis rs2880765 0.743 rs12906308 chr15:86008059 C/T cg10818794 chr15:86012489 AKAP13 0.31 8.37 0.31 3.57e-16 Coronary artery disease; BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg10729496 chr3:10149963 C3orf24 0.49 9.01 0.34 2.35e-18 Alzheimer's disease; BRCA cis rs61931739 0.500 rs10844862 chr12:34531965 A/T cg06521331 chr12:34319734 NA -0.53 -10.29 -0.38 4.23e-23 Morning vs. evening chronotype; BRCA cis rs1595825 0.786 rs77773624 chr2:198514845 G/A cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.96e-15 Ulcerative colitis; BRCA cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg05340658 chr4:99064831 C4orf37 0.69 16.84 0.55 6.06e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4742903 0.935 rs10820602 chr9:106861282 C/T cg14250997 chr9:106856677 SMC2 0.34 10.67 0.39 1.48e-24 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs4285028 0.948 rs35737776 chr3:121677856 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.96 0.3 7.64e-15 Corneal astigmatism; BRCA cis rs78663649 0.908 rs79641498 chr19:16521143 C/A cg05286348 chr19:16641544 CHERP -0.72 -9.68 -0.36 9.07e-21 White blood cell count; BRCA cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.86 -0.58 3.46e-58 Chronic sinus infection; BRCA cis rs12579753 0.833 rs1922566 chr12:82135030 T/C cg07988820 chr12:82153109 PPFIA2 -0.67 -11.4 -0.41 1.52e-27 Resting heart rate; BRCA cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg25237894 chr2:233734115 C2orf82 -0.41 -11.63 -0.42 1.69e-28 Coronary artery disease; BRCA cis rs7072216 0.763 rs2274246 chr10:100175060 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 8.8e-21 Metabolite levels; BRCA cis rs10465746 0.967 rs12757632 chr1:84416408 T/C cg10977910 chr1:84465055 TTLL7 0.51 10.2 0.37 1.02e-22 Obesity-related traits; BRCA cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg24531977 chr5:56204891 C5orf35 -0.86 -17.83 -0.58 4.82e-58 Initial pursuit acceleration; BRCA cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg18876405 chr7:65276391 NA -0.49 -10.65 -0.39 1.73e-24 Aortic root size; BRCA cis rs11758351 1.000 rs11755210 chr6:26202768 C/T cg01420254 chr6:26195488 NA 0.59 9.01 0.34 2.36e-18 Gout;Renal underexcretion gout; BRCA cis rs7408868 1.000 rs757472 chr19:15273221 T/C cg14696996 chr19:15285081 NOTCH3 0.83 13.22 0.46 1.99e-35 Pulse pressure; BRCA cis rs7633770 0.841 rs11130100 chr3:46679198 A/T cg11219411 chr3:46661640 NA -0.7 -19.42 -0.61 2.26e-66 Coronary artery disease; BRCA cis rs7246657 0.882 rs10412043 chr19:37826626 A/C cg14683738 chr19:37701593 ZNF585B 0.45 7.98 0.3 6.97e-15 Coronary artery calcification; BRCA cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg08000102 chr2:233561755 GIGYF2 -0.62 -13.59 -0.47 3.88e-37 Coronary artery disease; BRCA cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.31 -0.38 3.85e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03517284 chr6:25882590 NA -0.67 -15.82 -0.53 8.25e-48 Blood metabolite levels; BRCA cis rs9457247 0.612 rs2237273 chr6:167443017 T/C cg07741184 chr6:167504864 NA 0.27 8.06 0.3 3.74e-15 Crohn's disease; BRCA cis rs9309711 0.883 rs13429373 chr2:3477014 G/A cg10845886 chr2:3471009 TTC15 -0.81 -17.02 -0.56 7.83e-54 Neurofibrillary tangles; BRCA cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg22906224 chr7:99728672 NA 0.39 7.94 0.3 9.14e-15 Coronary artery disease; BRCA cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg10932868 chr11:921992 NA 0.39 9.36 0.35 1.33e-19 Alzheimer's disease (late onset); BRCA cis rs250677 1.000 rs250676 chr5:148425518 A/T cg12140854 chr5:148520817 ABLIM3 -0.41 -8.68 -0.32 3.21e-17 Breast cancer; BRCA cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg06784218 chr1:46089804 CCDC17 0.49 11.86 0.42 1.88e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2204008 0.837 rs10876019 chr12:37985477 C/T cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.31e-21 Bladder cancer; BRCA cis rs1577917 1.000 rs12199516 chr6:86726221 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.14 -0.43 1.1e-30 Response to antipsychotic treatment; BRCA cis rs9790314 0.613 rs34297047 chr3:160631478 A/G cg03342759 chr3:160939853 NMD3 0.43 8.69 0.33 2.92e-17 Morning vs. evening chronotype; BRCA cis rs2832191 0.692 rs2245517 chr21:30357968 C/T cg08807101 chr21:30365312 RNF160 0.77 20.2 0.62 1.45e-70 Dental caries; BRCA cis rs6700896 0.897 rs11208701 chr1:66134698 C/T cg04111102 chr1:66153794 NA 0.36 8.67 0.32 3.57e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs724568 0.527 rs11126147 chr2:67934313 C/A cg14046302 chr2:67939758 NA -0.38 -10.14 -0.37 1.72e-22 Major depressive disorder (broad); BRCA cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg11584989 chr19:19387371 SF4 0.64 13.5 0.47 1.03e-36 Bipolar disorder; BRCA cis rs636291 0.517 rs673254 chr1:10550352 C/T cg17425144 chr1:10567563 PEX14 0.57 14.63 0.5 5.28e-42 Prostate cancer; BRCA cis rs9297145 0.715 rs62473008 chr7:98751541 A/G cg05967295 chr7:98741636 SMURF1 0.94 17.15 0.56 1.55e-54 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA trans rs17685 0.753 rs1639609 chr7:75683581 T/C cg19862616 chr7:65841803 NCRNA00174 0.84 27.37 0.73 9.39e-110 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg16325326 chr1:53192061 ZYG11B -0.7 -18.17 -0.58 8.7e-60 Monocyte count; BRCA cis rs826838 0.904 rs10880981 chr12:38763911 G/A cg13010199 chr12:38710504 ALG10B 0.56 12.33 0.44 1.71e-31 Heart rate; BRCA cis rs13095912 0.778 rs7651346 chr3:185300395 G/A cg11274856 chr3:185301563 NA 0.56 13.58 0.47 4.55e-37 Systolic blood pressure; BRCA cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.52 0.41 4.72e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg17830980 chr10:43048298 ZNF37B -0.54 -12.95 -0.46 3.01e-34 Extrinsic epigenetic age acceleration; BRCA cis rs965469 1.000 rs2236107 chr20:3285821 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -9.78 -0.36 3.89e-21 IFN-related cytopenia; BRCA cis rs6840258 0.660 rs10516786 chr4:87892341 A/G cg08197287 chr4:87952173 AFF1 -0.44 -8.17 -0.31 1.65e-15 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs2070488 1.000 rs36006749 chr3:38443312 T/C cg24069376 chr3:38537580 EXOG 0.39 11.16 0.4 1.52e-26 Electrocardiographic conduction measures; BRCA cis rs9831754 0.906 rs6782626 chr3:78406178 T/C cg06138941 chr3:78371609 NA -0.74 -16.08 -0.54 4.24e-49 Calcium levels; BRCA cis rs4803468 1.000 rs9304593 chr19:41942875 A/C cg09537434 chr19:41945824 ATP5SL 1.03 25.67 0.71 2.15e-100 Height; BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg22920501 chr2:26401640 FAM59B 0.76 10.85 0.39 2.71e-25 Gut microbiome composition (summer); BRCA cis rs1874326 0.545 rs6467769 chr7:138109790 G/A cg18008034 chr7:138118925 NA -0.44 -9.22 -0.34 4.2e-19 Quantitative traits; BRCA cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg14036092 chr11:66035641 RAB1B 0.39 10.23 0.38 7.55e-23 Gout; BRCA cis rs634534 0.562 rs661335 chr11:65754061 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 10.12 0.37 1.94e-22 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs11690935 0.843 rs9784123 chr2:172785005 T/A cg13550731 chr2:172543902 DYNC1I2 -0.8 -22.9 -0.67 3.24e-85 Schizophrenia; BRCA cis rs16854884 0.837 rs13083224 chr3:143801696 C/T cg06585982 chr3:143692056 C3orf58 0.39 7.83 0.3 2.02e-14 Economic and political preferences (feminism/equality); BRCA cis rs10046574 0.764 rs28422979 chr7:135145924 C/T cg27474649 chr7:135195673 CNOT4 0.6 8.25 0.31 8.88e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.74 16.29 0.54 3.67e-50 Lymphocyte counts; BRCA cis rs7246657 0.722 rs16958861 chr19:38124179 G/A cg18154014 chr19:37997991 ZNF793 0.49 9.38 0.35 1.14e-19 Coronary artery calcification; BRCA cis rs832540 0.519 rs10036895 chr5:56273693 G/A cg18230493 chr5:56204884 C5orf35 -0.41 -8.14 -0.31 2.01e-15 Coronary artery disease; BRCA cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg21856205 chr7:94953877 PON1 -0.38 -8.25 -0.31 8.78e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg12016809 chr21:47604291 C21orf56 0.4 7.94 0.3 9.19e-15 Testicular germ cell tumor; BRCA cis rs10489202 0.513 rs4657731 chr1:168081255 C/T cg24449463 chr1:168025552 DCAF6 -0.46 -15.12 -0.51 2.29e-44 Schizophrenia; BRCA cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg14255062 chr9:123606675 PSMD5;LOC253039 0.31 8.38 0.31 3.27e-16 Birth weight; BRCA cis rs9486715 1.000 rs6902835 chr6:97063005 C/G cg06623918 chr6:96969491 KIAA0776 -0.8 -21.7 -0.65 1.17e-78 Headache; BRCA cis rs1865760 0.532 rs1061482 chr6:26086699 G/T cg17691542 chr6:26056736 HIST1H1C 0.54 11.71 0.42 8.01e-29 Height; BRCA trans rs1459104 0.636 rs12577480 chr11:54986004 A/C cg15704280 chr7:45808275 SEPT13 0.67 8.33 0.31 4.86e-16 Body mass index; BRCA cis rs6121246 0.909 rs1994251 chr20:30287328 T/G cg21427119 chr20:30132790 HM13 -0.42 -8.71 -0.33 2.62e-17 Mean corpuscular hemoglobin; BRCA cis rs7246657 0.943 rs10420722 chr19:37973774 C/G cg23950597 chr19:37808831 NA -0.75 -13.25 -0.46 1.43e-35 Coronary artery calcification; BRCA cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08704250 chr15:31115839 NA -0.36 -8.97 -0.33 3.23e-18 Huntington's disease progression; BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg25036284 chr2:26402008 FAM59B -0.8 -12.42 -0.44 7.32e-32 Gut microbiome composition (summer); BRCA cis rs3768617 0.811 rs12138053 chr1:182979560 C/T ch.1.3577855R chr1:183094577 LAMC1 0.45 9.98 0.37 6.55e-22 Fuchs's corneal dystrophy; BRCA cis rs12497850 0.897 rs9681717 chr3:48872998 A/G cg07636037 chr3:49044803 WDR6 0.97 28.42 0.75 1.72e-115 Parkinson's disease; BRCA cis rs1448094 0.621 rs7315084 chr12:86283817 A/G cg19622623 chr12:86230825 RASSF9 -0.3 -8.67 -0.32 3.6e-17 Major depressive disorder; BRCA cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.96 0.4 1e-25 Cognitive ability; BRCA cis rs965469 1.000 rs6051747 chr20:3307945 T/C cg25506879 chr20:3388711 C20orf194 -0.52 -10.36 -0.38 2.45e-23 IFN-related cytopenia; BRCA cis rs909674 0.541 rs5750816 chr22:39810379 A/G cg02038168 chr22:39784481 NA 0.39 7.93 0.3 9.62e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.33 0.41 2.95e-27 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.935 rs9770444 chr7:91783162 T/G cg01689657 chr7:91764605 CYP51A1 0.22 8.01 0.3 5.35e-15 Breast cancer; BRCA cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.44 0.66 1.16e-82 Chronic sinus infection; BRCA cis rs68170813 0.559 rs2894459 chr7:106960166 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.53 -0.32 1.09e-16 Coronary artery disease; BRCA cis rs1434579 0.572 rs926052 chr19:44952236 A/T cg15540054 chr19:45004280 ZNF180 0.51 11.19 0.4 1.15e-26 Tuberculosis; BRCA cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg19077165 chr18:44547161 KATNAL2 -0.5 -10.59 -0.39 3.09e-24 Personality dimensions; BRCA cis rs7412746 0.658 rs1027699 chr1:150811712 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.87 0.3 1.49e-14 Melanoma; BRCA trans rs453301 0.624 rs330049 chr8:9087299 C/T cg15556689 chr8:8085844 FLJ10661 0.4 11.36 0.41 2.26e-27 Joint mobility (Beighton score); BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24531977 chr5:56204891 C5orf35 -0.87 -18.02 -0.58 5.39e-59 Initial pursuit acceleration; BRCA cis rs6893300 0.785 rs6895902 chr5:179201847 C/T cg14593053 chr5:179126677 CANX -0.35 -7.82 -0.3 2.14e-14 Resting heart rate; BRCA cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.53 7.89 0.3 1.31e-14 Cerebrospinal P-tau181p levels; BRCA cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg11764359 chr7:65958608 NA -0.79 -18.16 -0.58 9.93e-60 Aortic root size; BRCA cis rs6005807 0.719 rs28818228 chr22:29042025 G/A cg12565055 chr22:29076175 TTC28 0.5 9.36 0.35 1.32e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.21 0.41 9.1e-27 Bipolar disorder; BRCA cis rs13136331 0.532 rs2615478 chr4:88579072 T/C cg22416721 chr4:88570574 DMP1 -0.6 -14.52 -0.5 1.71e-41 Sitting height ratio; BRCA cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg23173402 chr1:227635558 NA 0.55 9.37 0.35 1.22e-19 Major depressive disorder; BRCA cis rs514406 0.505 rs427319 chr1:53178807 T/G cg16325326 chr1:53192061 ZYG11B 0.9 25.07 0.7 3.93e-97 Monocyte count; BRCA cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg05623727 chr3:50126028 RBM5 -0.43 -10.14 -0.37 1.71e-22 Intelligence (multi-trait analysis); BRCA cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg18230493 chr5:56204884 C5orf35 -0.44 -9.01 -0.34 2.29e-18 Coronary artery disease; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.72 15.7 0.53 3.09e-47 Lymphocyte counts; BRCA cis rs12497850 0.931 rs7636057 chr3:48992582 C/T cg07636037 chr3:49044803 WDR6 0.97 29.54 0.76 1.35e-121 Parkinson's disease; BRCA cis rs2304069 0.954 rs6861548 chr5:149384680 A/G cg12661370 chr5:149340060 SLC26A2 0.57 8.3 0.31 6.42e-16 HIV-1 control; BRCA trans rs11098499 0.955 rs6815725 chr4:120158410 C/A cg25214090 chr10:38739885 LOC399744 0.49 10.65 0.39 1.69e-24 Corneal astigmatism; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -8.08 -0.3 3.28e-15 Total body bone mineral density; BRCA cis rs9287719 0.967 rs4613248 chr2:10744051 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.37 0.41 2.08e-27 Electroencephalogram traits; BRCA cis rs17270561 0.609 rs9358886 chr6:25758253 T/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.64 0.32 4.52e-17 Iron status biomarkers; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg02353165 chr6:42928485 GNMT -0.77 -18.97 -0.6 5.57e-64 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.67 -13.87 -0.48 1.9e-38 Personality dimensions; BRCA cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg19748678 chr4:122722346 EXOSC9 0.74 15.9 0.53 3.11e-48 Type 2 diabetes; BRCA trans rs3960554 0.740 rs10216079 chr7:75690988 A/C cg19862616 chr7:65841803 NCRNA00174 0.6 12.53 0.44 2.34e-32 Eotaxin levels; BRCA cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.29 0.31 6.45e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4742903 0.509 rs6479223 chr9:106921023 T/C cg14250997 chr9:106856677 SMC2 0.27 7.93 0.3 9.64e-15 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs17021463 0.902 rs36099342 chr4:95239783 T/C cg11021082 chr4:95130006 SMARCAD1 0.39 8.3 0.31 5.98e-16 Testicular germ cell tumor; BRCA cis rs9323205 0.911 rs60034431 chr14:51622437 C/A cg23942311 chr14:51606299 NA -0.44 -9.14 -0.34 8.24e-19 Cancer; BRCA cis rs9818758 0.607 rs56306491 chr3:49314960 G/A cg01304814 chr3:48885189 PRKAR2A 0.71 7.81 0.3 2.28e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs6066835 1.000 rs6125448 chr20:47353178 G/A cg18078177 chr20:47281410 PREX1 0.72 8.48 0.32 1.5e-16 Multiple myeloma; BRCA cis rs829661 0.947 rs829665 chr2:30724701 T/A cg07150166 chr2:30669952 LCLAT1 0.79 9.78 0.36 3.92e-21 Midgestational circulating levels of PBDEs (fetal genetic effect); BRCA cis rs6089829 0.962 rs4809462 chr20:61661560 A/G cg03213289 chr20:61660250 NA 0.63 16.78 0.55 1.19e-52 Prostate cancer (SNP x SNP interaction); BRCA cis rs9399135 0.967 rs6902438 chr6:135336587 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.77e-31 Red blood cell count; BRCA cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg25237894 chr2:233734115 C2orf82 0.4 11.51 0.41 5.56e-28 Coronary artery disease; BRCA cis rs7927771 1.000 rs12787330 chr11:47812311 C/T cg18512352 chr11:47633146 NA -0.34 -8.25 -0.31 9.16e-16 Subjective well-being; BRCA cis rs2243480 1.000 rs35421653 chr7:65363429 C/A cg18252515 chr7:66147081 NA -0.87 -12.08 -0.43 2.13e-30 Diabetic kidney disease; BRCA cis rs12310956 0.532 rs1525904 chr12:33962448 T/C cg06521331 chr12:34319734 NA -0.61 -11.11 -0.4 2.37e-26 Morning vs. evening chronotype; BRCA cis rs875971 1.000 rs6970030 chr7:65968679 T/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs6878727 0.850 rs10067094 chr5:123725725 C/T cg01806427 chr5:123737813 NA 0.42 9.63 0.36 1.39e-20 Breast cancer; BRCA cis rs10464366 0.544 rs12668821 chr7:39167846 T/A cg20302533 chr7:39170763 POU6F2 0.37 7.88 0.3 1.4e-14 IgG glycosylation; BRCA cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg12011299 chr4:100065546 ADH4 0.5 11.44 0.41 1.08e-27 Alcohol dependence; BRCA cis rs9814567 1.000 rs13096604 chr3:134250099 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg17691542 chr6:26056736 HIST1H1C 0.8 14.44 0.5 4.29e-41 Iron status biomarkers; BRCA cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.81e-18 Bone mineral density; BRCA cis rs7523050 0.908 rs17621621 chr1:109398917 G/T cg08274380 chr1:109419600 GPSM2 0.82 12.5 0.44 3.02e-32 Fat distribution (HIV); BRCA cis rs2294693 0.945 rs9369253 chr6:40986538 A/G cg14769373 chr6:40998127 UNC5CL -0.39 -7.84 -0.3 1.83e-14 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs2712184 0.660 rs10164732 chr2:217645669 A/T cg05032264 chr2:217675019 NA 0.34 8.16 0.31 1.72e-15 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs7524258 0.900 rs7514988 chr1:7271651 C/T cg07173049 chr1:7289937 CAMTA1 0.39 9.74 0.36 5.21e-21 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs12148488 0.966 rs12899062 chr15:75347641 A/C cg13906792 chr15:75199810 C15orf17 0.34 8.03 0.3 4.63e-15 Caffeine consumption; BRCA cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg04553112 chr3:125709451 NA -0.51 -8.33 -0.31 4.9e-16 Blood pressure (smoking interaction); BRCA cis rs7772486 0.790 rs9497427 chr6:146238302 T/A cg23711669 chr6:146136114 FBXO30 -0.67 -15.71 -0.53 2.83e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs6028335 0.674 rs16987779 chr20:37671455 C/T cg16355469 chr20:37678765 NA 0.51 9.08 0.34 1.37e-18 Alcohol and nicotine co-dependence; BRCA cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg24879335 chr3:133465180 TF 0.34 11.3 0.41 4.09e-27 Iron status biomarkers (transferrin levels); BRCA cis rs9420 0.961 rs7121169 chr11:57452543 G/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.51 -0.44 2.91e-32 Schizophrenia; BRCA cis rs35306767 0.807 rs1013505 chr10:953273 C/T cg20503657 chr10:835505 NA 1.04 17.61 0.57 6.61e-57 Eosinophil percentage of granulocytes; BRCA cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs8062405 1.000 rs1987472 chr16:28825777 C/T cg16576597 chr16:28551801 NUPR1 0.3 8.41 0.32 2.72e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2762353 0.603 rs10946798 chr6:25781853 T/G cg03264133 chr6:25882463 NA 0.38 8.31 0.31 5.71e-16 Blood metabolite levels; BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg22920501 chr2:26401640 FAM59B -0.66 -11.52 -0.41 4.74e-28 Gut microbiome composition (summer); BRCA cis rs7246657 0.943 rs10404920 chr19:37881556 T/C cg18154014 chr19:37997991 ZNF793 0.61 11.41 0.41 1.48e-27 Coronary artery calcification; BRCA cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg15017067 chr4:17643749 FAM184B 0.31 9.7 0.36 7.64e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10911251 0.546 rs2027085 chr1:183108611 G/T ch.1.3577855R chr1:183094577 LAMC1 -0.62 -15.84 -0.53 6.24e-48 Colorectal cancer; BRCA cis rs6840360 0.571 rs4696272 chr4:152528229 A/G cg22705602 chr4:152727874 NA -0.32 -8.31 -0.31 5.88e-16 Intelligence (multi-trait analysis); BRCA cis rs6598955 0.671 rs11247910 chr1:26645666 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.81 0.33 1.19e-17 Obesity-related traits; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg16145915 chr7:1198662 ZFAND2A -0.7 -19.18 -0.6 4.39e-65 Longevity;Endometriosis; BRCA cis rs17401966 0.894 rs12722830 chr1:10395134 A/G cg19773385 chr1:10388646 KIF1B -0.39 -8.51 -0.32 1.19e-16 Hepatocellular carcinoma; BRCA cis rs11031096 0.502 rs7935824 chr11:4046900 C/G cg18678763 chr11:4115507 RRM1 -0.35 -8.27 -0.31 7.96e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9868809 0.505 rs11719291 chr3:48735706 A/G cg00383909 chr3:49044727 WDR6 0.55 10.57 0.39 3.57e-24 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg03517284 chr6:25882590 NA -0.66 -15.45 -0.52 5.51e-46 Blood metabolite levels; BRCA cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg01028140 chr2:1542097 TPO -0.81 -15.85 -0.53 5.82e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3733585 0.673 rs4235347 chr4:9951956 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.32 -0.38 3.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg11062466 chr8:58055876 NA 0.41 8.01 0.3 5.44e-15 Developmental language disorder (linguistic errors); BRCA cis rs12618769 0.652 rs72823788 chr2:99213080 C/T cg10123293 chr2:99228465 UNC50 0.44 8.69 0.32 3.15e-17 Bipolar disorder; BRCA cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg06766960 chr11:133703094 NA -0.62 -12.87 -0.45 7.37e-34 Childhood ear infection; BRCA cis rs28735056 0.563 rs12968139 chr18:77685520 A/G cg20368463 chr18:77673604 PQLC1 -0.5 -12.39 -0.44 9.7e-32 Schizophrenia; BRCA cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg27165867 chr14:105738592 BRF1 -0.35 -8.28 -0.31 7.39e-16 Mean platelet volume;Platelet distribution width; BRCA trans rs10771431 0.597 rs10843142 chr12:9357502 A/G cg27600084 chr12:12264075 NA 0.36 7.96 0.3 8.09e-15 Breast size; BRCA cis rs17641971 0.708 rs10957317 chr8:49888870 C/T cg00325661 chr8:49890786 NA -0.34 -9.37 -0.35 1.25e-19 Blood metabolite levels; BRCA cis rs35306767 0.903 rs13377166 chr10:886259 G/A cg26597838 chr10:835615 NA 1.03 18.04 0.58 3.99e-59 Eosinophil percentage of granulocytes; BRCA cis rs597539 0.652 rs513615 chr11:68705504 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 17.04 0.56 5.6e-54 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs514406 0.644 rs4926928 chr1:53210163 G/T cg24675658 chr1:53192096 ZYG11B -0.62 -13.41 -0.47 2.5e-36 Monocyte count; BRCA cis rs6694270 0.529 rs4076925 chr1:19113026 C/T cg26220594 chr1:19110978 NA 0.44 8.25 0.31 8.85e-16 Drug-induced liver injury (nitrofurantoin); BRCA cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs881375 0.678 rs10985102 chr9:123707497 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.4 0.35 9.49e-20 Rheumatoid arthritis; BRCA cis rs17818399 0.749 rs13000560 chr2:46790997 G/T cg02822958 chr2:46747628 ATP6V1E2 0.62 11.39 0.41 1.75e-27 Height; BRCA trans rs1493916 1.000 rs11081827 chr18:31390228 C/A cg15819921 chr19:927150 ARID3A -0.47 -8.63 -0.32 4.91e-17 Life satisfaction; BRCA cis rs735396 1.000 rs1169306 chr12:121438311 C/T cg02403541 chr12:121454288 C12orf43 0.53 9.91 0.36 1.26e-21 N-glycan levels; BRCA cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.32 0.47 6.86e-36 Mean platelet volume; BRCA cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg11584989 chr19:19387371 SF4 0.63 13.51 0.47 8.75e-37 Bipolar disorder; BRCA cis rs56104184 0.775 rs73061699 chr19:49400511 T/C cg15549821 chr19:49342101 PLEKHA4 -0.67 -9.73 -0.36 5.99e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs3780486 0.846 rs12554995 chr9:33132044 A/G cg04842962 chr6:43655489 MRPS18A 1.11 39.06 0.84 1.91e-171 IgG glycosylation; BRCA cis rs12618769 0.652 rs3754872 chr2:99223925 A/T cg10123293 chr2:99228465 UNC50 0.42 8.58 0.32 7.36e-17 Bipolar disorder; BRCA cis rs290268 0.669 rs10993693 chr9:93557698 C/T cg02608019 chr9:93564028 SYK 0.51 11.39 0.41 1.65e-27 Platelet count; BRCA cis rs61935443 0.720 rs10859783 chr12:95285339 A/G cg21533806 chr12:95267307 NA 0.47 8.98 0.33 3.08e-18 Schizophrenia; BRCA cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg08109568 chr15:31115862 NA -0.44 -10.03 -0.37 4.22e-22 Huntington's disease progression; BRCA cis rs765787 0.530 rs12592055 chr15:45514477 C/T cg24006582 chr15:45444508 DUOX1 0.52 10.22 0.37 8.47e-23 Uric acid levels; BRCA cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg06671706 chr8:8559999 CLDN23 0.42 8.22 0.31 1.18e-15 Obesity-related traits; BRCA cis rs28595532 0.623 rs34958556 chr4:119222074 C/T cg21605333 chr4:119757512 SEC24D 0.82 8.56 0.32 8.11e-17 Cannabis dependence symptom count; BRCA cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg02574844 chr11:5959923 NA -0.43 -8.42 -0.32 2.55e-16 DNA methylation (variation); BRCA cis rs801193 0.636 rs2659895 chr7:66196471 C/A cg11764359 chr7:65958608 NA 0.79 18.77 0.6 6.04e-63 Aortic root size; BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg21143896 chr7:2802374 GNA12 -0.37 -9.33 -0.35 1.68e-19 Height; BRCA cis rs372883 0.648 rs382732 chr21:30719010 A/G cg08807101 chr21:30365312 RNF160 0.37 7.84 0.3 1.86e-14 Pancreatic cancer; BRCA cis rs17401966 0.931 rs2185252 chr1:10415912 T/C cg19773385 chr1:10388646 KIF1B -0.38 -8.27 -0.31 7.81e-16 Hepatocellular carcinoma; BRCA trans rs61931739 1.000 rs12304768 chr12:34000986 T/G cg26384229 chr12:38710491 ALG10B -0.42 -9.46 -0.35 5.97e-20 Morning vs. evening chronotype; BRCA cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg04455712 chr21:45112962 RRP1B 0.41 11.01 0.4 6.27e-26 Mean corpuscular volume; BRCA trans rs67340775 0.834 rs13218875 chr6:27884012 C/T cg01620082 chr3:125678407 NA -0.99 -11.44 -0.41 1.06e-27 Lung cancer in ever smokers; BRCA trans rs2736345 0.755 rs2736340 chr8:11343973 C/T cg15556689 chr8:8085844 FLJ10661 0.37 8.25 0.31 8.8e-16 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs10782582 0.609 rs111914775 chr1:76319036 C/T cg10523679 chr1:76189770 ACADM -0.41 -7.83 -0.3 2.02e-14 Daytime sleep phenotypes; BRCA cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg02951883 chr7:2050386 MAD1L1 -0.37 -8.81 -0.33 1.19e-17 Schizophrenia; BRCA cis rs3087591 0.919 rs2953004 chr17:29502723 C/T cg24425628 chr17:29625626 OMG;NF1 0.42 8.3 0.31 6.23e-16 Hip circumference; BRCA cis rs1577917 1.000 rs12213149 chr6:86668644 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -13.42 -0.47 2.3e-36 Response to antipsychotic treatment; BRCA cis rs1505368 0.567 rs972491 chr2:213316573 A/G cg20637307 chr2:213403960 ERBB4 -0.49 -11.67 -0.42 1.13e-28 Symmetrical dimethylarginine levels; BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg13628971 chr7:2884303 GNA12 0.49 9.89 0.36 1.44e-21 Height; BRCA cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg03452623 chr4:187889614 NA -0.32 -10.71 -0.39 1.04e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg19847866 chr10:1019161 NA 0.51 10.67 0.39 1.39e-24 Response to angiotensin II receptor blocker therapy; BRCA cis rs2421770 0.530 rs3847621 chr11:35364435 G/A cg13971030 chr11:35366721 SLC1A2 -0.45 -10.12 -0.37 2.02e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs586533 0.813 rs642457 chr11:99502908 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.45e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2304069 0.913 rs3812009 chr5:149380159 G/C cg12661370 chr5:149340060 SLC26A2 0.55 8.0 0.3 5.65e-15 HIV-1 control; BRCA cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.15e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg10295955 chr4:187884368 NA -0.87 -24.82 -0.7 9.34e-96 Lobe attachment (rater-scored or self-reported); BRCA cis rs34779708 0.931 rs7079498 chr10:35375344 C/T cg03585969 chr10:35415529 CREM 0.5 10.31 0.38 3.66e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs11069349 0.608 rs9585056 chr13:100081766 A/G cg25919922 chr13:100150906 NA -0.5 -9.68 -0.36 8.7e-21 Self-reported allergy; BRCA cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg20848291 chr7:100343083 ZAN -0.6 -12.68 -0.45 5.02e-33 Other erythrocyte phenotypes; BRCA cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.96 0.56 1.53e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg10495392 chr1:46806563 NSUN4 0.44 8.2 0.31 1.37e-15 Menopause (age at onset); BRCA cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg13397359 chr6:42928475 GNMT 0.81 21.88 0.65 1.3e-79 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -9.84 -0.36 2.22e-21 Schizophrenia; BRCA cis rs1997103 0.911 rs10238738 chr7:55412359 T/C cg17469321 chr7:55412551 NA 0.49 9.31 0.35 1.98e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07308232 chr7:1071921 C7orf50 -0.41 -8.39 -0.32 3.01e-16 Longevity;Endometriosis; BRCA cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg26061582 chr7:22766209 IL6 0.36 8.45 0.32 1.92e-16 Lung cancer; BRCA cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg05234568 chr11:5960015 NA -0.51 -10.04 -0.37 4.16e-22 DNA methylation (variation); BRCA cis rs1401999 1.000 rs9858774 chr3:183652736 G/A cg01324343 chr3:183735012 ABCC5 0.85 21.59 0.65 4.75e-78 Anterior chamber depth; BRCA cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg04455712 chr21:45112962 RRP1B -0.37 -9.57 -0.35 2.36e-20 Mean corpuscular volume; BRCA cis rs897080 0.515 rs786403 chr2:44710788 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.07 0.34 1.41e-18 Height; BRCA cis rs9287719 0.934 rs4622695 chr2:10744327 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs727479 0.523 rs7176330 chr15:51530458 A/G cg19946085 chr15:51559439 CYP19A1 -0.29 -7.98 -0.3 6.61e-15 Estradiol levels; BRCA cis rs870825 0.616 rs7682505 chr4:185640648 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.18 0.56 1.08e-54 Blood protein levels; BRCA cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.62 0.39 2.16e-24 Rheumatoid arthritis; BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg21782813 chr7:2030301 MAD1L1 0.39 10.06 0.37 3.42e-22 Bipolar disorder and schizophrenia; BRCA cis rs9296092 0.538 rs7761464 chr6:33519417 C/A cg13560919 chr6:33536144 NA -0.84 -18.43 -0.59 3.8e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs72772090 0.539 rs72775818 chr5:96193215 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -11.04 -0.4 4.51e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7927592 0.956 rs2155730 chr11:68329474 T/C cg20283391 chr11:68216788 NA -0.44 -8.96 -0.33 3.43e-18 Total body bone mineral density; BRCA trans rs7939886 0.920 rs11231901 chr11:55811529 A/G cg15704280 chr7:45808275 SEPT13 0.63 8.07 0.3 3.51e-15 Myopia (pathological); BRCA cis rs7572263 0.724 rs6749281 chr2:209050696 C/A cg23998903 chr2:209048830 C2orf80 -0.42 -8.68 -0.32 3.16e-17 Glioma;Non-glioblastoma glioma; BRCA cis rs7666738 0.830 rs6532701 chr4:98745134 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.78 0.5 9.4e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs16910800 0.731 rs59333536 chr11:23191649 G/A cg20040320 chr11:23191996 NA -0.59 -10.23 -0.38 7.61e-23 Cancer; BRCA cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg25208724 chr1:156163844 SLC25A44 0.89 18.06 0.58 3.34e-59 Testicular germ cell tumor; BRCA trans rs2204008 0.837 rs7974888 chr12:37945215 A/G cg06521331 chr12:34319734 NA -0.54 -10.31 -0.38 3.6e-23 Bladder cancer; BRCA cis rs17401966 1.000 rs7530167 chr1:10453374 A/G cg03954927 chr1:10346856 KIF1B 0.45 12.59 0.45 1.28e-32 Hepatocellular carcinoma; BRCA trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg25482853 chr8:67687455 SGK3 1.05 16.95 0.56 1.78e-53 Lung disease severity in cystic fibrosis; BRCA cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg20476274 chr7:133979776 SLC35B4 0.66 19.34 0.61 5.83e-66 Mean platelet volume; BRCA cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -9.09 -0.34 1.19e-18 Personality dimensions; BRCA cis rs7666738 0.830 rs7697315 chr4:98938764 T/C cg05340658 chr4:99064831 C4orf37 0.65 15.73 0.53 2.24e-47 Colonoscopy-negative controls vs population controls; BRCA cis rs524281 0.861 rs7946917 chr11:65956577 A/G cg16950941 chr11:66035639 RAB1B -0.38 -7.96 -0.3 7.71e-15 Electroencephalogram traits; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg18402987 chr7:1209562 NA 0.45 9.53 0.35 3.15e-20 Longevity;Endometriosis; BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg19723775 chr5:179050963 HNRNPH1 0.37 8.91 0.33 5.42e-18 Lung cancer; BRCA cis rs9790314 0.560 rs4856701 chr3:161044106 G/T cg03342759 chr3:160939853 NMD3 -0.63 -14.08 -0.49 2.13e-39 Morning vs. evening chronotype; BRCA cis rs11122272 0.701 rs2790894 chr1:231505587 T/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -12.33 -0.44 1.78e-31 Hemoglobin concentration; BRCA cis rs11229555 0.645 rs12802960 chr11:58174775 T/C cg15696309 chr11:58395628 NA -0.45 -9.66 -0.36 1.11e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg23708337 chr7:1209742 NA 0.63 8.85 0.33 8.71e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg23625390 chr15:77176239 SCAPER 0.39 9.19 0.34 5.6e-19 Blood metabolite levels; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg00149659 chr3:10157352 C3orf10 0.8 13.84 0.48 2.74e-38 Alzheimer's disease; BRCA cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg00339695 chr16:24857497 SLC5A11 -0.53 -11.3 -0.41 3.87e-27 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.26 -0.38 5.83e-23 Alzheimer's disease (late onset); BRCA cis rs10911251 0.546 rs1051473 chr1:183114146 T/C ch.1.3577855R chr1:183094577 LAMC1 0.6 15.19 0.52 1.04e-44 Colorectal cancer; BRCA cis rs7493 0.755 rs740264 chr7:95021803 T/G cg19678392 chr7:94953810 PON1 -0.43 -8.98 -0.33 2.9e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg08213375 chr14:104286397 PPP1R13B 0.63 17.11 0.56 2.55e-54 Schizophrenia; BRCA cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 10.9 0.4 1.77e-25 Rheumatoid arthritis; BRCA cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg02743256 chr7:2109353 MAD1L1 -0.45 -8.0 -0.3 6.04e-15 Bipolar disorder; BRCA cis rs6120849 0.901 rs6088737 chr20:33745938 A/G cg24642439 chr20:33292090 TP53INP2 0.47 8.45 0.32 1.99e-16 Protein C levels; BRCA cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg21535247 chr6:8435926 SLC35B3 0.41 9.14 0.34 8.33e-19 Motion sickness; BRCA cis rs7729447 0.804 rs116090595 chr5:32698148 T/G cg16267343 chr5:32710456 NPR3 0.47 9.89 0.36 1.43e-21 Blood pressure; BRCA cis rs6570726 0.935 rs399169 chr6:145836353 C/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs78456975 0.506 rs6756310 chr2:1549809 A/G cg01028140 chr2:1542097 TPO -0.67 -14.19 -0.49 6e-40 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.5 0.57 2.71e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs9291683 0.546 rs13110307 chr4:10044364 T/C cg26043149 chr18:55253948 FECH 0.4 8.71 0.33 2.66e-17 Bone mineral density; BRCA cis rs9875589 0.509 rs1488375 chr3:14061563 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.29 7.81 0.3 2.32e-14 Ovarian reserve; BRCA cis rs8060686 0.920 rs2292316 chr16:67861134 C/G cg26727032 chr16:67993705 SLC12A4 0.37 7.86 0.3 1.62e-14 HDL cholesterol;Metabolic syndrome; BRCA cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg13395646 chr4:1353034 KIAA1530 -0.49 -9.05 -0.34 1.74e-18 Obesity-related traits; BRCA cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.71 0.33 2.63e-17 Motion sickness; BRCA cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg04478727 chr12:58166393 METTL1;FAM119B -0.51 -9.28 -0.34 2.68e-19 Multiple sclerosis; BRCA cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg06618935 chr21:46677482 NA -0.38 -8.46 -0.32 1.85e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.641 rs9978858 chr21:45085552 A/G cg04455712 chr21:45112962 RRP1B 0.47 11.33 0.41 3.05e-27 Mean corpuscular volume; BRCA cis rs8038465 0.622 rs62004587 chr15:73859016 A/C cg15420318 chr15:73925796 NPTN 0.46 9.52 0.35 3.4e-20 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9467773 1.000 rs6940053 chr6:26562122 C/T cg09904177 chr6:26538194 HMGN4 0.55 17.63 0.57 5.8e-57 Intelligence (multi-trait analysis); BRCA cis rs939658 0.776 rs11631411 chr15:79445816 C/T cg17916960 chr15:79447300 NA -0.47 -11.88 -0.43 1.45e-29 Refractive error; BRCA cis rs10504073 0.669 rs12548464 chr8:50023867 C/T cg00325661 chr8:49890786 NA 0.38 11.04 0.4 4.49e-26 Blood metabolite ratios; BRCA cis rs921968 0.541 rs41461846 chr2:219313354 A/G cg02176678 chr2:219576539 TTLL4 -0.53 -13.48 -0.47 1.29e-36 Mean corpuscular hemoglobin concentration; BRCA cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg24642439 chr20:33292090 TP53INP2 0.51 11.35 0.41 2.44e-27 Glomerular filtration rate (creatinine); BRCA trans rs6964833 0.935 rs34630792 chr7:74061197 G/C cg07504079 chr7:72649617 NCF1B -0.48 -9.4 -0.35 9.18e-20 Menarche (age at onset); BRCA cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg06494592 chr3:125709126 NA -0.53 -8.32 -0.31 5.28e-16 Blood pressure (smoking interaction); BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg08132940 chr7:1081526 C7orf50 -0.6 -8.99 -0.34 2.69e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg11822812 chr5:140052017 DND1 -0.3 -8.41 -0.32 2.7e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs11229555 0.645 rs7116007 chr11:58218701 C/T cg15696309 chr11:58395628 NA -0.52 -10.83 -0.39 3.29e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg24130564 chr14:104152367 KLC1 0.58 15.89 0.53 3.71e-48 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.15 0.58 1.14e-59 Cognitive function; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg10862848 chr6:42927986 GNMT -0.34 -14.37 -0.49 8.6e-41 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs16976116 0.901 rs1061824 chr15:55495963 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs473651 0.935 rs477041 chr2:239355995 C/G cg14266287 chr2:239334506 ASB1 0.33 8.03 0.3 4.77e-15 Multiple system atrophy; BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg08470875 chr2:26401718 FAM59B -0.51 -8.31 -0.31 5.76e-16 Gut microbiome composition (summer); BRCA cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg19077165 chr18:44547161 KATNAL2 -0.64 -14.93 -0.51 1.89e-43 Personality dimensions; BRCA cis rs6665290 0.835 rs11578479 chr1:227210888 A/T cg10327440 chr1:227177885 CDC42BPA -1.09 -38.02 -0.83 3.29e-166 Myeloid white cell count; BRCA cis rs1557765 0.527 rs4756887 chr11:17394597 T/G cg15432903 chr11:17409602 KCNJ11 0.4 8.63 0.32 4.7e-17 Body mass index;Social communication problems; BRCA trans rs4650994 0.525 rs2493864 chr1:178545003 A/C cg05059571 chr16:84539110 KIAA1609 -0.54 -12.5 -0.44 3.18e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs9790314 1.000 rs336591 chr3:161078080 A/G cg04691961 chr3:161091175 C3orf57 -0.6 -15.12 -0.51 2.13e-44 Morning vs. evening chronotype; BRCA cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg20607798 chr8:58055168 NA 0.48 8.37 0.31 3.52e-16 Developmental language disorder (linguistic errors); BRCA trans rs7618501 0.633 rs4688689 chr3:50035542 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.31 8.72 0.33 2.38e-17 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg05347473 chr6:146136440 FBXO30 -0.42 -8.3 -0.31 6.12e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg15083037 chr5:83017644 HAPLN1 -0.53 -10.58 -0.39 3.15e-24 Prostate cancer; BRCA cis rs365132 1.000 rs601923 chr5:176417386 C/G cg16309518 chr5:176445507 NA -0.52 -13.39 -0.47 3.14e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs7945705 0.875 rs10769957 chr11:8809016 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.51 -10.43 -0.38 1.23e-23 Hemoglobin concentration; BRCA cis rs1420338 1.000 rs918038 chr7:34153768 A/G cg01275685 chr7:34179230 BMPER -0.47 -10.21 -0.37 8.89e-23 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7553864 0.667 rs10873820 chr1:87605973 C/G cg17420885 chr1:87600446 LOC339524 0.43 9.09 0.34 1.28e-18 Smoking behavior; BRCA cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg21475434 chr5:93447410 FAM172A 0.68 9.2 0.34 5e-19 Diabetic retinopathy; BRCA cis rs34375054 0.525 rs7133614 chr12:125605957 C/T cg25124228 chr12:125621409 AACS -0.55 -11.99 -0.43 5.26e-30 Post bronchodilator FEV1/FVC ratio; BRCA cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg08999081 chr20:33150536 PIGU 0.36 9.35 0.35 1.51e-19 Coronary artery disease; BRCA trans rs6964833 1.000 rs4717906 chr7:74086247 G/A cg07504079 chr7:72649617 NCF1B -0.47 -9.24 -0.34 3.67e-19 Menarche (age at onset); BRCA cis rs1577917 0.958 rs34795473 chr6:86461799 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.35 -0.44 1.49e-31 Response to antipsychotic treatment; BRCA cis rs17021463 0.966 rs7657789 chr4:95178589 C/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -10.3 -0.38 3.91e-23 Testicular germ cell tumor; BRCA cis rs17092148 0.887 rs6059931 chr20:33175338 A/G cg16810054 chr20:33298113 TP53INP2 -0.47 -10.28 -0.38 5e-23 Neuroticism; BRCA cis rs7737355 0.947 rs39600 chr5:130828649 A/T cg06307176 chr5:131281290 NA 0.52 10.4 0.38 1.71e-23 Life satisfaction; BRCA cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg24642439 chr20:33292090 TP53INP2 0.54 11.68 0.42 1.02e-28 Glomerular filtration rate (creatinine); BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg02951883 chr7:2050386 MAD1L1 -0.49 -11.37 -0.41 2.03e-27 Schizophrenia; BRCA cis rs11227306 0.934 rs7102454 chr11:65594820 C/T cg00576331 chr11:65640516 EFEMP2 0.37 7.91 0.3 1.1e-14 DNA methylation (variation); BRCA cis rs55882075 0.535 rs67484565 chr5:179110574 G/T cg14593053 chr5:179126677 CANX 0.38 9.49 0.35 4.65e-20 Monocyte percentage of white cells; BRCA cis rs7772486 0.875 rs13198450 chr6:146370524 C/A cg05347473 chr6:146136440 FBXO30 0.4 7.97 0.3 7.27e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg11814155 chr7:99998594 ZCWPW1 0.52 9.23 0.34 3.8e-19 Platelet count; BRCA cis rs7246657 0.722 rs2291002 chr19:38033926 G/A cg23950597 chr19:37808831 NA -0.51 -8.65 -0.32 4.11e-17 Coronary artery calcification; BRCA cis rs12477438 0.501 rs1133977 chr2:99741984 G/T cg08885076 chr2:99613938 TSGA10 -0.44 -10.42 -0.38 1.38e-23 Chronic sinus infection; BRCA cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg10295955 chr4:187884368 NA -0.89 -26.18 -0.72 3.29e-103 Lobe attachment (rater-scored or self-reported); BRCA cis rs4900538 0.821 rs7012 chr14:102814945 C/T cg18135206 chr14:102964638 TECPR2 -0.91 -21.74 -0.65 7.34e-79 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2204008 0.693 rs12372025 chr12:38202028 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.99e-54 Bladder cancer; BRCA cis rs208520 1.000 rs12209225 chr6:66996443 G/T cg07460842 chr6:66804631 NA 0.88 14.08 0.49 2.06e-39 Exhaled nitric oxide output; BRCA cis rs4481887 0.893 rs10888349 chr1:248448625 T/C cg00666640 chr1:248458726 OR2T12 0.35 9.11 0.34 1.02e-18 Common traits (Other); BRCA cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg01877450 chr7:97915802 BRI3 -0.37 -8.31 -0.31 5.8e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs617791 0.508 rs1047464 chr11:65769456 A/T cg09783858 chr11:65769428 EIF1AD;BANF1 0.47 8.76 0.33 1.77e-17 Breast cancer; BRCA cis rs826838 1.000 rs4575342 chr12:38663831 G/A cg13010199 chr12:38710504 ALG10B 0.57 12.58 0.45 1.44e-32 Heart rate; BRCA cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.4 0.32 2.97e-16 Menopause (age at onset); BRCA cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg08392591 chr16:89556376 ANKRD11 0.53 13.04 0.46 1.26e-34 Multiple myeloma (IgH translocation); BRCA cis rs7586879 0.796 rs36071142 chr2:25080570 C/T cg04586622 chr2:25135609 ADCY3 0.38 9.13 0.34 9.06e-19 Body mass index; BRCA cis rs911186 0.812 rs6932590 chr6:27248931 T/C cg12292205 chr6:26970375 C6orf41 -0.55 -9.73 -0.36 5.79e-21 Autism spectrum disorder or schizophrenia; BRCA cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg18357645 chr12:58087776 OS9 0.42 11.89 0.43 1.39e-29 Celiac disease or Rheumatoid arthritis; BRCA cis rs735860 0.763 rs1429146 chr6:53130285 C/T cg10236188 chr6:53219634 NA -0.41 -8.89 -0.33 6.41e-18 Glaucoma; BRCA cis rs9611519 0.566 rs4821981 chr22:41415644 A/C cg03806693 chr22:41940476 POLR3H 0.41 8.01 0.3 5.52e-15 Neuroticism; BRCA cis rs9814567 1.000 rs9985356 chr3:134232920 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.91 0.33 5.45e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs79976124 0.879 rs12214239 chr6:66636059 A/G cg07460842 chr6:66804631 NA 0.61 10.47 0.38 8.69e-24 Type 2 diabetes; BRCA cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg12935359 chr14:103987150 CKB -0.59 -13.94 -0.48 9.65e-39 Body mass index; BRCA cis rs4237845 0.788 rs1962047 chr12:58292707 G/A cg02175503 chr12:58329896 NA 0.48 10.23 0.38 7.31e-23 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -11.53 -0.41 4.6e-28 Gut microbiome composition (summer); BRCA cis rs10504073 0.584 rs72641612 chr8:49947986 C/T cg00325661 chr8:49890786 NA 0.51 14.59 0.5 8.25e-42 Blood metabolite ratios; BRCA cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg01262667 chr19:19385393 TM6SF2 -0.42 -10.65 -0.39 1.71e-24 Tonsillectomy; BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -8.46 -0.32 1.88e-16 Schizophrenia; BRCA cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03264133 chr6:25882463 NA -0.5 -10.9 -0.4 1.77e-25 Intelligence (multi-trait analysis); BRCA cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg16489826 chr6:160211363 TCP1;MRPL18 -0.56 -11.9 -0.43 1.23e-29 Age-related macular degeneration (geographic atrophy); BRCA cis rs11971779 0.616 rs6974907 chr7:139068729 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg12379764 chr21:47803548 PCNT -0.44 -9.62 -0.36 1.51e-20 Testicular germ cell tumor; BRCA cis rs6062302 0.522 rs3787107 chr20:62230576 G/A cg16989086 chr20:62203971 PRIC285 0.52 8.8 0.33 1.3e-17 Glioblastoma; BRCA cis rs3767633 0.925 rs1553444 chr1:161813515 C/T cg09175582 chr1:161736000 ATF6 0.54 9.74 0.36 5.51e-21 IgG glycosylation; BRCA trans rs2204008 0.715 rs11495369 chr12:38238673 T/C cg06521331 chr12:34319734 NA -0.49 -9.11 -0.34 1.06e-18 Bladder cancer; BRCA cis rs9361491 0.543 rs1507153 chr6:79484386 C/A cg05283184 chr6:79620031 NA -0.35 -8.11 -0.31 2.61e-15 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg03433033 chr1:76189801 ACADM 0.7 13.1 0.46 6.8000000000000005e-35 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2836974 0.932 rs6517523 chr21:40557332 T/C cg17971929 chr21:40555470 PSMG1 0.79 18.52 0.59 1.25e-61 Cognitive function; BRCA trans rs6582630 0.555 rs10880613 chr12:38509553 C/T cg06521331 chr12:34319734 NA -0.51 -9.35 -0.35 1.41e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg11843238 chr5:131593191 PDLIM4 0.35 9.05 0.34 1.71e-18 Breast cancer; BRCA cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg13010199 chr12:38710504 ALG10B -0.39 -8.42 -0.32 2.41e-16 Bladder cancer; BRCA cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg02551604 chr5:131831745 NA -0.4 -14.94 -0.51 1.73e-43 Asthma (sex interaction); BRCA cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg10621924 chr7:39171070 POU6F2 0.38 8.06 0.3 3.69e-15 IgG glycosylation; BRCA cis rs796364 0.806 rs10445792 chr2:201078821 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.59 -8.57 -0.32 7.59e-17 Schizophrenia; BRCA cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.89e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg00339695 chr16:24857497 SLC5A11 0.49 9.75 0.36 5.07e-21 Intelligence (multi-trait analysis); BRCA cis rs3806843 1.000 rs1030165 chr5:140185448 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.74 -0.36 5.32e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs1005277 0.565 rs2474565 chr10:38380828 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.87 -0.56 4.17e-53 Extrinsic epigenetic age acceleration; BRCA cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 13.02 0.46 1.47e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs7267979 1.000 rs2500405 chr20:25360826 A/G cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2243480 1.000 rs13235972 chr7:65883605 C/T cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.961 rs7395303 chr11:986221 T/A cg10932868 chr11:921992 NA 0.39 9.45 0.35 6.39e-20 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.56 0.39 3.97e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs9291683 0.595 rs11722930 chr4:10035454 G/A cg26043149 chr18:55253948 FECH 0.42 8.99 0.34 2.84e-18 Bone mineral density; BRCA cis rs701145 0.640 rs2122365 chr3:153930808 T/G cg17054900 chr3:154042577 DHX36 0.43 8.18 0.31 1.59e-15 Coronary artery disease; BRCA cis rs12612619 0.732 rs3754734 chr2:27299598 G/T cg00617064 chr2:27272375 NA -0.32 -8.38 -0.31 3.35e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg08085267 chr17:45401833 C17orf57 -0.63 -13.77 -0.48 5.88e-38 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs708547 0.766 rs781545 chr4:57732025 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.48 -10.79 -0.39 4.84e-25 Response to bleomycin (chromatid breaks); BRCA cis rs3733585 0.699 rs6449176 chr4:9967843 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 2.0500000000000001e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2860975 1.000 rs2860975 chr10:96766934 G/T cg09036531 chr10:96991505 NA 0.38 8.04 0.3 4.39e-15 Immune response to smallpox vaccine (IL-6); BRCA cis rs965469 1.000 rs6051723 chr20:3278512 C/A cg25506879 chr20:3388711 C20orf194 -0.54 -10.52 -0.38 5.35e-24 IFN-related cytopenia; BRCA cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg22907277 chr7:1156413 C7orf50 0.62 10.82 0.39 3.66e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8114671 0.869 rs66535333 chr20:33656666 G/A cg24642439 chr20:33292090 TP53INP2 -0.44 -8.82 -0.33 1.12e-17 Height; BRCA cis rs870825 0.616 rs7658186 chr4:185622509 T/C cg04058563 chr4:185651563 MLF1IP 0.77 16.89 0.56 3.35e-53 Blood protein levels; BRCA cis rs13394619 0.605 rs12476319 chr2:11748406 A/G cg07314298 chr2:11723111 GREB1 0.36 8.06 0.3 3.77e-15 Endometriosis; BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg10729496 chr3:10149963 C3orf24 0.49 9.34 0.35 1.5700000000000001e-19 Alzheimer's disease; BRCA cis rs6782228 0.606 rs2712405 chr3:128332082 T/C cg16766828 chr3:128327626 NA -0.42 -9.22 -0.34 4.22e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs9308433 0.529 rs4655246 chr1:214502898 G/C cg06198575 chr1:214491504 SMYD2 0.56 12.29 0.44 2.71e-31 IgG glycosylation; BRCA cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg16339924 chr4:17578868 LAP3 0.76 18.78 0.6 5.3e-63 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg22875332 chr1:76189707 ACADM 0.7 14.59 0.5 7.98e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs514406 0.505 rs395169 chr1:53174071 G/A cg08859206 chr1:53392774 SCP2 -0.42 -8.44 -0.32 2.14e-16 Monocyte count; BRCA cis rs7520050 1.000 rs12143096 chr1:46469763 G/A cg24296786 chr1:45957014 TESK2 0.44 9.82 0.36 2.68e-21 Red blood cell count;Reticulocyte count; BRCA cis rs875971 0.522 rs709604 chr7:65497434 A/G cg11764359 chr7:65958608 NA -0.62 -13.6 -0.47 3.49e-37 Aortic root size; BRCA cis rs7264396 0.690 rs17093156 chr20:34438583 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.13 0.31 2.28e-15 Total cholesterol levels; BRCA cis rs6539267 0.741 rs35816179 chr12:106693710 T/C cg02476566 chr12:106696527 TCP11L2 0.53 10.04 0.37 3.84e-22 Tourette syndrome; BRCA cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.15 0.62 2.91e-70 Chronic sinus infection; BRCA trans rs11976180 0.953 rs2961127 chr7:143762737 G/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs910316 0.763 rs175490 chr14:75545685 A/G cg11812906 chr14:75593930 NEK9 0.62 14.16 0.49 8.36e-40 Height; BRCA cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.774 rs11615665 chr12:38328162 T/A cg06521331 chr12:34319734 NA -0.49 -8.88 -0.33 6.67e-18 Bladder cancer; BRCA cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg20587970 chr11:113659929 NA -1.35 -24.25 -0.69 1.34e-92 Hip circumference adjusted for BMI; BRCA cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.97 0.3 7.05e-15 Depression; BRCA cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg17143192 chr8:8559678 CLDN23 0.53 10.27 0.38 5.21e-23 Obesity-related traits; BRCA cis rs1401999 1.000 rs6800217 chr3:183685893 T/C cg20387954 chr3:183756860 HTR3D 0.45 10.12 0.37 2.06e-22 Anterior chamber depth; BRCA cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.43 12.04 0.43 3.15e-30 Monocyte percentage of white cells; BRCA trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg26384229 chr12:38710491 ALG10B 0.75 16.74 0.55 2e-52 Morning vs. evening chronotype; BRCA cis rs8017423 0.647 rs12587362 chr14:90821227 G/T cg04374321 chr14:90722782 PSMC1 -0.49 -11.89 -0.43 1.3e-29 Mortality in heart failure; BRCA cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg24692254 chr21:30365293 RNF160 0.78 21.58 0.65 5.52e-78 Dental caries; BRCA cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9467773 0.595 rs3846845 chr6:26444915 G/A cg09904177 chr6:26538194 HMGN4 -0.37 -9.81 -0.36 3.06e-21 Intelligence (multi-trait analysis); BRCA cis rs7590720 1.000 rs4674048 chr2:216900023 G/A cg12620499 chr2:216877984 MREG 0.79 22.34 0.66 3.64e-82 Alcohol dependence; BRCA cis rs17102884 0.506 rs11845397 chr14:75404587 G/A cg08847533 chr14:75593920 NEK9 -0.46 -9.35 -0.35 1.4e-19 Neuroticism; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.68 -14.27 -0.49 2.76e-40 Lymphocyte counts; BRCA cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg09469691 chr10:81107165 PPIF 0.54 11.38 0.41 1.83e-27 Height; BRCA cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -8.48 -0.32 1.57e-16 Intelligence (multi-trait analysis); BRCA cis rs7523273 1.000 rs12184327 chr1:207978780 A/G cg22525895 chr1:207977042 MIR29B2 -0.48 -11.81 -0.42 3e-29 Schizophrenia; BRCA cis rs2880765 0.835 rs7169429 chr15:86036648 C/T cg10818794 chr15:86012489 AKAP13 -0.29 -8.05 -0.3 3.93e-15 Coronary artery disease; BRCA cis rs62103177 0.525 rs4283293 chr18:77759582 A/G cg02751453 chr18:77725136 HSBP1L1 0.38 9.2 0.34 4.99e-19 Opioid sensitivity; BRCA cis rs877282 0.945 rs71491303 chr10:772884 G/T cg17470449 chr10:769945 NA 0.5 9.35 0.35 1.44e-19 Uric acid levels; BRCA cis rs56104184 0.775 rs55981795 chr19:49401952 A/C cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs1459104 1.000 rs116220196 chr11:55293221 C/T cg15704280 chr7:45808275 SEPT13 0.63 7.91 0.3 1.11e-14 Body mass index; BRCA cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg18230493 chr5:56204884 C5orf35 -0.62 -13.3 -0.47 8.67e-36 Initial pursuit acceleration; BRCA cis rs875971 0.964 rs697969 chr7:65558478 C/A cg12463550 chr7:65579703 CRCP -0.37 -7.84 -0.3 1.88e-14 Aortic root size; BRCA cis rs2012796 1.000 rs8008024 chr14:81818492 A/G cg02996355 chr14:81879375 NA 0.52 10.08 0.37 2.83e-22 Night sleep phenotypes; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.79 -12.42 -0.44 6.74e-32 Platelet count; BRCA cis rs9287719 1.000 rs9679122 chr2:10751710 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.88 -0.3 1.41e-14 Prostate cancer; BRCA cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 10.7 0.39 1.12e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1348850 0.561 rs1838890 chr2:178410938 C/A cg27490568 chr2:178487706 NA 0.5 8.52 0.32 1.17e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg08754478 chr10:133766260 PPP2R2D -0.64 -13.0 -0.46 1.85e-34 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9633740 1.000 rs7910643 chr10:82251769 G/A cg00277334 chr10:82204260 NA -0.47 -7.91 -0.3 1.15e-14 Post bronchodilator FEV1; BRCA cis rs13095912 0.889 rs6778977 chr3:185302532 T/G cg11274856 chr3:185301563 NA 0.35 8.76 0.33 1.72e-17 Systolic blood pressure; BRCA cis rs7917772 0.512 rs11594073 chr10:104308193 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.47 -14.17 -0.49 7.43e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 14.69 0.5 2.66e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.68e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3733585 0.673 rs6849729 chr4:9958732 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2795502 1.000 rs2796575 chr10:43374911 A/G cg20628663 chr10:43360327 NA 0.71 13.78 0.48 5.25e-38 Blood protein levels; BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg21724239 chr8:58056113 NA 0.62 9.78 0.36 3.87e-21 Developmental language disorder (linguistic errors); BRCA cis rs12586317 0.620 rs7147571 chr14:35530236 T/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.3 -0.38 3.98e-23 Psoriasis; BRCA cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg24549020 chr5:56110836 MAP3K1 -0.39 -8.13 -0.31 2.18e-15 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.56 0.5 1.14e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs7949030 0.590 rs12225213 chr11:62350248 T/A cg22862634 chr11:62369728 EML3;MTA2 0.55 12.71 0.45 3.8e-33 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs67478160 0.619 rs11623546 chr14:104269098 A/G cg08213375 chr14:104286397 PPP1R13B 0.66 18.7 0.59 1.49e-62 Schizophrenia; BRCA cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg14343924 chr8:8086146 FLJ10661 0.39 8.39 0.31 3.19e-16 Mood instability; BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 10.04 0.37 3.87e-22 Tonsillectomy; BRCA cis rs7582180 0.629 rs11686842 chr2:100956139 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.65 0.42 1.45e-28 Intelligence (multi-trait analysis); BRCA cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg20887711 chr4:1340912 KIAA1530 -0.59 -12.99 -0.46 1.99e-34 Obesity-related traits; BRCA trans rs629535 0.814 rs78813708 chr8:70073977 A/G cg21567404 chr3:27674614 NA 1.0 20.79 0.64 1e-73 Dupuytren's disease; BRCA cis rs10746514 0.833 rs12039526 chr1:232272599 C/T cg09506761 chr1:232265262 NA -0.43 -8.46 -0.32 1.85e-16 Response to statin therapy; BRCA trans rs12310956 0.510 rs1825903 chr12:33870437 G/C cg26384229 chr12:38710491 ALG10B 0.39 9.22 0.34 4.38e-19 Morning vs. evening chronotype; BRCA trans rs1005277 0.541 rs1740741 chr10:38515334 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.65e-33 Extrinsic epigenetic age acceleration; BRCA cis rs72634258 0.842 rs7545745 chr1:8165667 T/A cg00042356 chr1:8021962 PARK7 -0.52 -9.25 -0.34 3.34e-19 Inflammatory bowel disease; BRCA cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg12373951 chr3:133503437 NA -0.45 -10.54 -0.38 4.62e-24 Iron status biomarkers; BRCA cis rs883565 0.610 rs4676600 chr3:39157011 A/G cg26331595 chr3:39149181 GORASP1;TTC21A 0.38 8.17 0.31 1.61e-15 Handedness; BRCA cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg15017067 chr4:17643749 FAM184B 0.31 9.61 0.36 1.64e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9858542 0.903 rs11921590 chr3:49644193 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.95 -0.37 9.01e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9788682 0.747 rs2036533 chr15:78781687 G/A cg24631222 chr15:78858424 CHRNA5 0.49 9.5 0.35 4.08e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs12617721 0.718 rs1857745 chr2:99016975 T/C cg10123293 chr2:99228465 UNC50 0.5 9.11 0.34 1.06e-18 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs12618769 0.597 rs3769729 chr2:99102810 T/C cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs9942416 0.660 rs67803720 chr5:74984408 A/T cg19683494 chr5:74908142 NA 0.48 9.1 0.34 1.15e-18 Age-related disease endophenotypes; BRCA cis rs2276314 0.857 rs62101393 chr18:33592168 T/C cg19628046 chr18:33552617 C18orf21 0.54 10.88 0.4 2e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs73001065 0.688 rs59148799 chr19:19484008 A/G cg03709012 chr19:19516395 GATAD2A 1.03 15.1 0.51 2.74e-44 LDL cholesterol; BRCA cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.85 -0.39 2.71e-25 Personality dimensions; BRCA cis rs6120849 0.802 rs6087682 chr20:33752897 A/T cg24642439 chr20:33292090 TP53INP2 0.48 8.56 0.32 8.7e-17 Protein C levels; BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg04166393 chr7:2884313 GNA12 0.5 9.53 0.35 3.29e-20 Height; BRCA cis rs10045504 0.502 rs17456482 chr5:38737783 G/C cg15396434 chr5:38725168 NA -0.57 -11.05 -0.4 4.13e-26 Night sleep phenotypes; BRCA trans rs3733585 0.674 rs7375643 chr4:9955239 A/G cg26043149 chr18:55253948 FECH -0.4 -9.07 -0.34 1.42e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17604090 0.818 rs28390296 chr7:29687091 C/T cg19413766 chr7:29689036 LOC646762 -0.52 -8.06 -0.3 3.86e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg03354898 chr7:1950403 MAD1L1 -0.44 -8.58 -0.32 6.99e-17 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 17.62 0.57 5.88e-57 Platelet count; BRCA cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg03146154 chr1:46216737 IPP 0.52 11.52 0.41 4.93e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13064411 0.696 rs9839921 chr3:113199093 G/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs908922 0.676 rs4240887 chr1:152530510 C/T cg20991723 chr1:152506922 NA -0.36 -8.2 -0.31 1.27e-15 Hair morphology; BRCA cis rs4631830 0.720 rs2843560 chr10:51512129 C/G cg20129853 chr10:51489980 NA 0.31 8.53 0.32 1.09e-16 Prostate-specific antigen levels; BRCA cis rs7246967 0.673 rs12979173 chr19:22820681 C/T cg23217946 chr19:22817039 ZNF492 0.47 8.48 0.32 1.56e-16 Bronchopulmonary dysplasia; BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 11.04 0.4 4.6e-26 Platelet count; BRCA cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs7249142 0.562 rs11085253 chr19:19277517 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.43 -9.18 -0.34 5.82e-19 IgG glycosylation; BRCA cis rs6121246 0.697 rs6087716 chr20:30229040 C/T cg13852791 chr20:30311386 BCL2L1 0.8 14.98 0.51 1.08e-43 Mean corpuscular hemoglobin; BRCA cis rs870825 0.860 rs72703518 chr4:185602109 T/C cg04058563 chr4:185651563 MLF1IP 0.82 13.82 0.48 3.56e-38 Blood protein levels; BRCA cis rs2712184 0.756 rs2712181 chr2:217654869 C/T cg05032264 chr2:217675019 NA 0.37 9.03 0.34 1.95e-18 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg21226059 chr5:178986404 RUFY1 -0.48 -13.32 -0.47 6.82e-36 Lung cancer; BRCA trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.97 -0.3 7.4e-15 Corneal astigmatism; BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg04944784 chr2:26401820 FAM59B -0.96 -16.33 -0.54 2.27e-50 Gut microbiome composition (summer); BRCA cis rs9527 0.641 rs10786732 chr10:104762535 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.05 0.37 3.83e-22 Arsenic metabolism; BRCA cis rs2191566 1.000 rs367499 chr19:44504981 G/A cg20607764 chr19:44506953 ZNF230 0.49 10.85 0.39 2.77e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs13046373 0.505 rs2832962 chr21:32008332 T/C cg14062083 chr21:31802829 KRTAP13-4 0.35 9.39 0.35 1.02e-19 HDL cholesterol; BRCA cis rs9462027 0.628 rs9689820 chr6:34752963 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.2e-15 Systemic lupus erythematosus; BRCA cis rs10193935 0.901 rs222478 chr2:42656919 G/T cg27598129 chr2:42591480 NA -0.69 -11.85 -0.42 2.09e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.41e-39 Initial pursuit acceleration; BRCA cis rs4988958 0.565 rs10206291 chr2:103038863 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.35 0.31 4.15e-16 Asthma (childhood onset); BRCA cis rs7172677 0.960 rs1602360 chr15:75420761 G/A cg14664628 chr15:75095509 CSK -0.39 -8.24 -0.31 9.45e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1538970 0.816 rs11211124 chr1:45962409 T/C cg05343316 chr1:45956843 TESK2 0.69 14.39 0.49 7.2e-41 Platelet count; BRCA cis rs72781680 0.848 rs72798057 chr2:23976731 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.61 0.32 5.89e-17 Lymphocyte counts; BRCA cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg03433033 chr1:76189801 ACADM 0.45 8.91 0.33 5.21e-18 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg10556349 chr10:835070 NA 0.6 8.41 0.32 2.75e-16 Eosinophil percentage of granulocytes; BRCA cis rs2882667 0.929 rs17207828 chr5:138299835 A/G cg04439458 chr5:138467593 SIL1 -0.39 -10.13 -0.37 1.87e-22 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs61931739 0.500 rs10844829 chr12:34304916 G/T cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.82e-20 Morning vs. evening chronotype; BRCA cis rs4363385 0.818 rs9659389 chr1:152989844 T/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.75 -0.33 1.95e-17 Inflammatory skin disease; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg12444411 chr7:2802554 GNA12 -0.38 -9.28 -0.34 2.62e-19 Height; BRCA cis rs2832077 0.943 rs2832099 chr21:30173460 A/G cg24692254 chr21:30365293 RNF160 -0.45 -8.15 -0.31 1.99e-15 Cognitive test performance; BRCA trans rs208520 1.000 rs208521 chr6:66953625 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -14.49 -0.5 2.3e-41 Exhaled nitric oxide output; BRCA cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg00071950 chr4:10020882 SLC2A9 0.54 13.37 0.47 4e-36 Bone mineral density; BRCA cis rs1577917 0.655 rs6454472 chr6:86224053 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.3 8.15 0.31 1.91e-15 Response to antipsychotic treatment; BRCA cis rs7633770 0.664 rs7373994 chr3:46701114 C/G cg11219411 chr3:46661640 NA -0.54 -13.41 -0.47 2.74e-36 Coronary artery disease; BRCA cis rs11227306 0.934 rs2303384 chr11:65640204 C/T cg00576331 chr11:65640516 EFEMP2 0.44 9.82 0.36 2.61e-21 DNA methylation (variation); BRCA trans rs11098499 0.955 rs4145951 chr4:120155817 A/G cg25214090 chr10:38739885 LOC399744 0.51 10.99 0.4 7.57e-26 Corneal astigmatism; BRCA cis rs4148883 0.675 rs34511427 chr4:100105405 G/T cg12011299 chr4:100065546 ADH4 0.39 10.32 0.38 3.31e-23 Alcohol dependence; BRCA cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA cis rs7312933 0.618 rs7954523 chr12:42681508 A/G cg23032229 chr12:42720167 PPHLN1;ZCRB1 -0.33 -7.95 -0.3 8.28e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7677751 0.767 rs6846502 chr4:55062090 T/C cg17187183 chr4:55093834 PDGFRA 0.4 8.27 0.31 7.59e-16 Corneal astigmatism; BRCA cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 2.02e-19 Schizophrenia; BRCA cis rs3857067 0.806 rs4693375 chr4:95133241 C/A cg11021082 chr4:95130006 SMARCAD1 -0.41 -9.64 -0.36 1.3e-20 QT interval; BRCA cis rs11098499 0.954 rs6822679 chr4:120402702 A/C cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.8e-45 Corneal astigmatism; BRCA cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg17366294 chr4:99064904 C4orf37 -0.53 -11.37 -0.41 2.17e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg03433033 chr1:76189801 ACADM 0.69 13.59 0.47 3.92e-37 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg20573242 chr4:122745356 CCNA2 0.49 10.92 0.4 1.43e-25 Type 2 diabetes; BRCA cis rs9814567 0.806 rs12637301 chr3:134317966 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg05863683 chr7:1912471 MAD1L1 0.38 8.32 0.31 5.21e-16 Schizophrenia; BRCA cis rs1420338 1.000 rs1420338 chr7:34143256 G/A cg01275685 chr7:34179230 BMPER -0.45 -9.89 -0.36 1.54e-21 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs67460515 0.892 rs11711413 chr3:160998910 C/G cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Parkinson's disease; BRCA cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg08847533 chr14:75593920 NEK9 -0.86 -22.05 -0.66 1.46e-80 Height; BRCA cis rs11690935 0.688 rs7600835 chr2:172521827 C/T cg13550731 chr2:172543902 DYNC1I2 -0.58 -14.49 -0.5 2.48e-41 Schizophrenia; BRCA cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.13 -0.58 1.42e-59 Extrinsic epigenetic age acceleration; BRCA cis rs798554 0.607 rs1182151 chr7:2909225 C/G cg19346786 chr7:2764209 NA -0.29 -8.1 -0.31 2.84e-15 Height; BRCA cis rs17376456 0.877 rs35075119 chr5:93385457 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 7.84 0.3 1.86e-14 Diabetic retinopathy; BRCA cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg16339924 chr4:17578868 LAP3 0.56 13.86 0.48 2.31e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg11266682 chr4:10021025 SLC2A9 0.44 11.75 0.42 5.11e-29 Bone mineral density; BRCA cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg15017067 chr4:17643749 FAM184B 0.31 9.26 0.34 3.15e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs78456975 0.943 rs6721243 chr2:1580250 A/G cg12573674 chr2:1569213 NA -0.49 -9.75 -0.36 4.88e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.87 -0.33 7.32e-18 Alzheimer's disease (late onset); BRCA cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg05834845 chr3:195489306 MUC4 0.52 8.2 0.31 1.33e-15 Lung disease severity in cystic fibrosis; BRCA trans rs11165623 0.602 rs4127309 chr1:97006892 T/C cg10631902 chr5:14652156 NA -0.42 -12.01 -0.43 4.36e-30 Hip circumference;Waist circumference; BRCA cis rs9400271 0.632 rs9374070 chr6:109586455 G/A cg21918786 chr6:109611834 NA -0.32 -7.93 -0.3 9.7e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -11.93 -0.43 9.18e-30 Tonsillectomy; BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.6 -0.32 5.96e-17 Total body bone mineral density; BRCA cis rs11711311 1.000 rs2242108 chr3:113433903 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 6.05e-21 IgG glycosylation; BRCA cis rs453301 0.606 rs7462373 chr8:8899318 G/C cg15556689 chr8:8085844 FLJ10661 -0.36 -9.62 -0.36 1.45e-20 Joint mobility (Beighton score); BRCA cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA cis rs2559856 0.967 rs2695290 chr12:102087844 A/G cg15068132 chr12:102092402 CHPT1 0.28 7.89 0.3 1.28e-14 Blood protein levels; BRCA cis rs7666738 0.512 rs1648536 chr4:99019881 G/T cg05340658 chr4:99064831 C4orf37 -0.48 -11.16 -0.4 1.56e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs6964587 1.000 rs10234434 chr7:91673308 A/T cg17063962 chr7:91808500 NA 0.53 12.43 0.44 6.47e-32 Breast cancer; BRCA cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg27029518 chr18:72166324 CNDP2 -0.33 -7.81 -0.3 2.3e-14 Refractive error; BRCA cis rs2580764 0.566 rs2968793 chr2:55285024 C/T cg09592903 chr2:55203963 RTN4 0.35 8.96 0.33 3.42e-18 Mean platelet volume; BRCA cis rs172166 0.694 rs536704 chr6:28092603 T/G cg10876282 chr6:28092338 ZSCAN16 0.42 8.32 0.31 5.24e-16 Cardiac Troponin-T levels; BRCA cis rs6964587 0.626 rs9008 chr7:91502407 C/G cg17063962 chr7:91808500 NA -0.55 -12.65 -0.45 6.88e-33 Breast cancer; BRCA cis rs858239 0.600 rs4628176 chr7:23142566 C/T cg23682824 chr7:23144976 KLHL7 0.42 11.23 0.41 7.86e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs921968 0.565 rs1078803 chr2:219606538 A/C cg02176678 chr2:219576539 TTLL4 0.4 10.8 0.39 4.22e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.6 -11.82 -0.42 2.77e-29 Multiple sclerosis; BRCA cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs11955398 0.585 rs4398599 chr5:60032413 T/C cg02684056 chr5:59996105 DEPDC1B -0.38 -8.96 -0.33 3.63e-18 Intelligence (multi-trait analysis); BRCA cis rs1371614 0.679 rs4441421 chr2:27142091 G/A cg12368169 chr2:27073192 DPYSL5 0.3 8.86 0.33 7.98e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -13.28 -0.47 1.05e-35 Systolic blood pressure; BRCA cis rs637571 0.522 rs503524 chr11:65751764 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 13.99 0.48 5.4e-39 Eosinophil percentage of white cells; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg22963979 chr7:1858916 MAD1L1 -0.4 -8.37 -0.31 3.72e-16 Bipolar disorder and schizophrenia; BRCA cis rs250677 0.687 rs40523 chr5:148444186 A/T cg23229984 chr5:148520753 ABLIM3 -0.34 -8.46 -0.32 1.89e-16 Breast cancer; BRCA cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -9.29 -0.34 2.46e-19 Alzheimer's disease (late onset); BRCA cis rs4727027 0.901 rs10952792 chr7:148760501 C/T cg23583168 chr7:148888333 NA -0.83 -18.96 -0.6 6.51e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg07493874 chr5:1342172 CLPTM1L -0.53 -15.15 -0.51 1.68e-44 Lung cancer; BRCA cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg24977027 chr2:88469347 THNSL2 0.57 9.56 0.35 2.48e-20 Plasma clusterin levels; BRCA cis rs2882667 0.690 rs2693963 chr5:138106326 T/G cg04439458 chr5:138467593 SIL1 0.31 7.85 0.3 1.74e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6813479 0.524 rs2612114 chr4:137745484 G/T cg16185213 chr4:137733633 NA 0.34 8.2 0.31 1.3e-15 Longevity; BRCA trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg11693508 chr17:37793320 STARD3 -0.67 -13.29 -0.47 8.8e-36 Bipolar disorder; BRCA cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg23205692 chr1:25664452 TMEM50A 0.43 10.44 0.38 1.1e-23 Erythrocyte sedimentation rate; BRCA cis rs637571 0.780 rs677029 chr11:65683531 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.43 8.77 0.33 1.65e-17 Eosinophil percentage of white cells; BRCA cis rs6582630 0.547 rs1589388 chr12:38416025 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.86 -0.36 1.91e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs11690935 0.549 rs796839 chr2:172916214 A/C cg13550731 chr2:172543902 DYNC1I2 0.54 13.6 0.47 3.6e-37 Schizophrenia; BRCA cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg18230493 chr5:56204884 C5orf35 -0.72 -14.02 -0.49 3.82e-39 Initial pursuit acceleration; BRCA cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg15605315 chr1:45957053 TESK2 0.45 9.17 0.34 6.57e-19 High light scatter reticulocyte count; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs7617773 0.779 rs3731487 chr3:48229624 C/T cg11946769 chr3:48343235 NME6 0.67 13.92 0.48 1.13e-38 Coronary artery disease; BRCA cis rs2070433 0.539 rs721131 chr21:47957767 T/C cg12379764 chr21:47803548 PCNT 0.56 11.99 0.43 5.14e-30 Lymphocyte counts; BRCA cis rs7246657 0.943 rs4802766 chr19:37981933 T/C cg23950597 chr19:37808831 NA -0.71 -12.54 -0.44 2.16e-32 Coronary artery calcification; BRCA cis rs875971 0.545 rs1796222 chr7:66057154 T/C cg11764359 chr7:65958608 NA -0.61 -10.5 -0.38 6.84e-24 Aortic root size; BRCA cis rs73086581 1.000 rs6107393 chr20:3987738 C/T cg02187196 chr20:3869020 PANK2 0.49 8.9 0.33 5.72e-18 Response to antidepressants in depression; BRCA cis rs2505998 0.833 rs1864404 chr10:43604390 A/T cg15436174 chr10:43711423 RASGEF1A -0.43 -8.33 -0.31 4.83e-16 Hirschsprung disease; BRCA trans rs3733585 0.699 rs6844316 chr4:9958977 A/G cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg16049864 chr8:95962084 TP53INP1 -0.48 -11.95 -0.43 7.9e-30 Type 2 diabetes; BRCA cis rs60843830 0.661 rs62116681 chr2:104197 A/T cg25945732 chr2:264204 ACP1;SH3YL1 0.49 9.23 0.34 3.77e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg02951883 chr7:2050386 MAD1L1 -0.58 -13.45 -0.47 1.81e-36 Bipolar disorder and schizophrenia; BRCA cis rs6542838 0.703 rs7593332 chr2:99467991 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.23 -0.31 1.04e-15 Fear of minor pain; BRCA trans rs6076960 0.684 rs6054059 chr20:6262472 G/T cg21095983 chr6:86352623 SYNCRIP 0.41 9.14 0.34 8.34e-19 Smooth-surface caries; BRCA cis rs281408 0.559 rs204248 chr19:49216224 G/C cg13540341 chr19:49222985 MAMSTR 0.4 10.18 0.37 1.15e-22 Urinary metabolites (H-NMR features); BRCA trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg15556689 chr8:8085844 FLJ10661 -0.39 -9.7 -0.36 7.41e-21 Retinal vascular caliber; BRCA cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg16423285 chr20:60520624 NA 0.58 11.69 0.42 9.39e-29 Obesity-related traits; BRCA cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg11057378 chr10:81107060 PPIF 0.38 9.47 0.35 5.36e-20 Height; BRCA cis rs11874712 0.966 rs9962380 chr18:43678706 C/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.33 7.85 0.3 1.74e-14 Migraine - clinic-based; BRCA cis rs6964587 0.839 rs11767135 chr7:91551245 T/G cg17063962 chr7:91808500 NA -0.5 -11.74 -0.42 5.93e-29 Breast cancer; BRCA cis rs17023223 0.537 rs12087987 chr1:119734821 C/A cg05756136 chr1:119680316 WARS2 -0.41 -7.94 -0.3 8.97e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs10911251 0.546 rs10911260 chr1:183106230 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.58 -15.4 -0.52 9.17e-46 Colorectal cancer; BRCA trans rs6582630 0.519 rs11514056 chr12:38284001 G/T cg06521331 chr12:34319734 NA -0.51 -9.78 -0.36 3.77e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg03161606 chr19:29218774 NA 0.44 8.19 0.31 1.42e-15 Methadone dose in opioid dependence; BRCA cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.82 21.0 0.64 7.09e-75 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs1707322 0.752 rs6658700 chr1:46160260 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6598955 0.543 rs12125620 chr1:26552238 G/A cg04990556 chr1:26633338 UBXN11 0.71 11.96 0.43 6.87e-30 Obesity-related traits; BRCA cis rs1953600 0.870 rs1049550 chr10:81926702 G/A cg04850286 chr10:81895943 PLAC9 -0.32 -9.08 -0.34 1.31e-18 Sarcoidosis; BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg19346786 chr7:2764209 NA -0.33 -9.73 -0.36 5.7e-21 Height; BRCA cis rs495337 0.736 rs633829 chr20:48493291 G/A cg17835207 chr20:48524531 SPATA2 -0.52 -11.34 -0.41 2.64e-27 Psoriasis; BRCA cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg18850127 chr7:39170497 POU6F2 0.56 12.17 0.43 8.72e-31 IgG glycosylation; BRCA trans rs6598955 0.671 rs17163746 chr1:26564230 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg18225595 chr11:63971243 STIP1 0.5 8.89 0.33 6.45e-18 Mean platelet volume; BRCA cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg14019146 chr3:50243930 SLC38A3 -0.33 -7.84 -0.3 1.95e-14 Intelligence (multi-trait analysis); BRCA cis rs10267417 0.657 rs28833898 chr7:19861022 G/A cg07541023 chr7:19748670 TWISTNB 0.51 9.11 0.34 1.05e-18 Night sleep phenotypes; BRCA cis rs4713118 0.662 rs13218430 chr6:28029837 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs3806843 0.766 rs801399 chr5:140034844 C/T cg26395211 chr5:140044315 WDR55 0.36 8.17 0.31 1.71e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg16179182 chr5:140090404 VTRNA1-1 0.46 10.71 0.39 9.54e-25 Depressive symptoms (multi-trait analysis); BRCA trans rs61931739 0.534 rs1912773 chr12:34097401 T/C cg26384229 chr12:38710491 ALG10B 0.68 14.08 0.49 1.99e-39 Morning vs. evening chronotype; BRCA cis rs6546550 0.935 rs3771541 chr2:70031797 C/G cg02498382 chr2:70120550 SNRNP27 -0.48 -9.86 -0.36 1.88e-21 Prevalent atrial fibrillation; BRCA cis rs9533799 1.000 rs9533798 chr13:44802505 C/G cg19190762 chr13:44806055 NA -0.4 -8.65 -0.32 4.13e-17 Amyotrophic lateral sclerosis; BRCA cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs2625529 0.668 rs8192386 chr15:72513148 A/C cg16672083 chr15:72433130 SENP8 0.81 17.03 0.56 6.64e-54 Red blood cell count; BRCA cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.18 -0.49 7.38e-40 Initial pursuit acceleration; BRCA cis rs1801251 1.000 rs2305137 chr2:233712049 G/A cg25237894 chr2:233734115 C2orf82 -0.41 -11.93 -0.43 9.26e-30 Coronary artery disease; BRCA cis rs812925 0.519 rs967968 chr2:61656056 C/G cg15711740 chr2:61764176 XPO1 0.33 8.05 0.3 4.05e-15 Immature fraction of reticulocytes; BRCA cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15320075 chr8:145703422 NA -0.56 -12.8 -0.45 1.41e-33 Age at first birth; BRCA cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg23649088 chr2:200775458 C2orf69 -0.61 -11.42 -0.41 1.25e-27 Schizophrenia; BRCA cis rs1371867 0.817 rs7846076 chr8:101327629 A/G cg06636551 chr8:101224915 SPAG1 -0.33 -7.81 -0.3 2.43e-14 Atrioventricular conduction; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 15.16 0.51 1.39e-44 Platelet count; BRCA cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg18305652 chr10:134549665 INPP5A 0.51 13.24 0.46 1.52e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs586533 0.846 rs1790267 chr11:99501018 G/T cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.62 0.36 1.54e-20 Menopause (age at onset); BRCA cis rs896854 0.967 rs13257021 chr8:95965695 A/G cg13393036 chr8:95962371 TP53INP1 -0.33 -9.02 -0.34 2.2e-18 Type 2 diabetes; BRCA trans rs11165623 0.602 rs12120893 chr1:97007132 C/T cg10631902 chr5:14652156 NA -0.4 -11.14 -0.4 1.91e-26 Hip circumference;Waist circumference; BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg04944784 chr2:26401820 FAM59B 0.89 12.36 0.44 1.33e-31 Gut microbiome composition (summer); BRCA cis rs11190604 0.767 rs12360395 chr10:102194074 A/T cg07080220 chr10:102295463 HIF1AN 0.44 9.69 0.36 8.15e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg00990874 chr7:1149470 C7orf50 -0.43 -8.7 -0.33 2.74e-17 Bronchopulmonary dysplasia; BRCA cis rs66887589 0.720 rs2036858 chr4:120249237 A/C cg09307838 chr4:120376055 NA 0.47 10.13 0.37 1.8e-22 Diastolic blood pressure; BRCA cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.78e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7937682 0.961 rs4936682 chr11:111629743 T/G cg09085632 chr11:111637200 PPP2R1B 1.01 23.71 0.68 1.19e-89 Primary sclerosing cholangitis; BRCA cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg26395211 chr5:140044315 WDR55 0.38 8.69 0.32 3.14e-17 Depressive symptoms (multi-trait analysis); BRCA trans rs2197308 0.692 rs67352173 chr12:37906912 A/T cg06521331 chr12:34319734 NA -0.54 -10.29 -0.38 4.42e-23 Morning vs. evening chronotype; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg16145915 chr7:1198662 ZFAND2A -0.46 -9.23 -0.34 4.03e-19 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg03517284 chr6:25882590 NA -0.51 -11.52 -0.41 4.72e-28 Blood metabolite levels; BRCA cis rs921968 0.541 rs488767 chr2:219466860 G/T cg10223061 chr2:219282414 VIL1 -0.27 -8.15 -0.31 1.91e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -12.95 -0.46 3.03e-34 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs9325144 0.560 rs7971313 chr12:38653413 A/G cg13010199 chr12:38710504 ALG10B -0.36 -8.77 -0.33 1.6e-17 Morning vs. evening chronotype; BRCA cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg06191203 chr2:152266755 RIF1 0.43 12.29 0.44 2.48e-31 Lung cancer; BRCA cis rs1997103 1.000 rs6954474 chr7:55404847 A/G cg17469321 chr7:55412551 NA 0.49 9.16 0.34 6.81e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs12477438 0.765 rs6740054 chr2:99576631 C/T cg08885076 chr2:99613938 TSGA10 -0.53 -12.04 -0.43 3.07e-30 Chronic sinus infection; BRCA trans rs1493916 0.748 rs4799355 chr18:31313124 G/T cg15819921 chr19:927150 ARID3A -0.42 -8.18 -0.31 1.5e-15 Life satisfaction; BRCA cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg27446573 chr6:127587934 RNF146 -0.84 -17.31 -0.57 2.36e-55 Breast cancer; BRCA cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 14.37 0.49 8.64e-41 Colorectal cancer; BRCA cis rs9811920 0.809 rs796976 chr3:99621002 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.57 14.0 0.48 4.68e-39 Axial length; BRCA cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.04 0.66 1.58e-80 Chronic sinus infection; BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg27170947 chr2:26402098 FAM59B -0.94 -16.89 -0.56 3.36e-53 Gut microbiome composition (summer); BRCA cis rs17401966 0.522 rs2027330 chr1:10275592 C/T cg03954927 chr1:10346856 KIF1B 0.35 10.61 0.39 2.41e-24 Hepatocellular carcinoma; BRCA cis rs2832077 0.527 rs11088095 chr21:30223188 A/T cg24692254 chr21:30365293 RNF160 -0.52 -11.83 -0.42 2.44e-29 Cognitive test performance; BRCA cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 27.08 0.73 3.96e-108 Chronic sinus infection; BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg03709012 chr19:19516395 GATAD2A 0.81 19.13 0.6 8.08e-65 Tonsillectomy; BRCA cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.68 -0.5 2.95e-42 Chronic sinus infection; BRCA cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg06494592 chr3:125709126 NA -0.53 -8.25 -0.31 9.2e-16 Blood pressure (smoking interaction); BRCA cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg03146154 chr1:46216737 IPP 0.46 10.15 0.37 1.56e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg12386194 chr3:101231763 SENP7 0.45 9.5 0.35 4.28e-20 Colorectal cancer; BRCA cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg02503808 chr4:7069936 GRPEL1 0.86 19.93 0.62 4.13e-69 Monocyte percentage of white cells; BRCA cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.13e-15 Tonsillectomy; BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg11062466 chr8:58055876 NA -0.5 -8.54 -0.32 9.85e-17 Developmental language disorder (linguistic errors); BRCA cis rs965469 1.000 rs6139088 chr20:3329063 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -10.7 -0.39 1.07e-24 IFN-related cytopenia; BRCA cis rs1018836 0.770 rs13266461 chr8:91652817 T/C cg16814680 chr8:91681699 NA -0.76 -16.92 -0.56 2.5e-53 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs1499972 0.941 rs6807173 chr3:117642281 T/G cg07612923 chr3:117604196 NA 0.6 8.1 0.31 2.82e-15 Schizophrenia; BRCA cis rs6878727 0.815 rs988409 chr5:123730483 G/A cg01806427 chr5:123737813 NA 0.4 9.02 0.34 2.15e-18 Breast cancer; BRCA cis rs561341 1.000 rs554078 chr17:30330109 A/C cg00745463 chr17:30367425 LRRC37B -0.61 -9.87 -0.36 1.72e-21 Hip circumference adjusted for BMI; BRCA cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.54 8.62 0.32 5.39e-17 Renal function-related traits (BUN); BRCA cis rs7267979 0.934 rs2257464 chr20:25265872 C/T cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.01e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7917772 0.582 rs11191352 chr10:104372244 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.31 0.49 1.79e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg19729930 chr2:74357872 NA 0.58 14.65 0.5 3.99e-42 Gestational age at birth (maternal effect); BRCA cis rs875971 0.508 rs6947808 chr7:66045082 A/G cg18876405 chr7:65276391 NA -0.57 -13.67 -0.48 1.64e-37 Aortic root size; BRCA cis rs4285028 0.747 rs1920299 chr3:121593769 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.69 12.83 0.45 1.05e-33 Multiple sclerosis; BRCA cis rs36051895 0.589 rs62543573 chr9:5201675 A/G cg02405213 chr9:5042618 JAK2 -0.42 -7.81 -0.3 2.43e-14 Pediatric autoimmune diseases; BRCA cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.26 0.34 2.96e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs7537052 0.669 rs6686192 chr1:36642991 C/T cg24686825 chr1:36642396 MAP7D1 -0.53 -12.07 -0.43 2.35e-30 Schizophrenia; BRCA cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg05623727 chr3:50126028 RBM5 0.43 10.16 0.37 1.38e-22 Intelligence (multi-trait analysis); BRCA cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg20503657 chr10:835505 NA -0.54 -9.89 -0.36 1.42e-21 Response to angiotensin II receptor blocker therapy; BRCA cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg11845111 chr2:191398756 TMEM194B -0.35 -7.93 -0.3 1.01e-14 Pulse pressure; BRCA trans rs11992162 0.967 rs10108320 chr8:11832263 A/T cg14343924 chr8:8086146 FLJ10661 -0.39 -8.11 -0.31 2.58e-15 Monocyte count; BRCA trans rs1972460 0.506 rs62012050 chr15:82532274 T/G cg04831495 chr15:85060580 GOLGA6L5 -0.42 -10.37 -0.38 2.24e-23 Intelligence (multi-trait analysis); BRCA cis rs796364 0.568 rs11890894 chr2:201072055 C/T cg23649088 chr2:200775458 C2orf69 0.6 11.57 0.42 3.14e-28 Schizophrenia; BRCA cis rs561341 0.556 rs542244 chr17:30307242 T/C cg12193833 chr17:30244370 NA -0.53 -8.53 -0.32 1.08e-16 Hip circumference adjusted for BMI; BRCA cis rs701145 0.938 rs355788 chr3:154000612 T/C cg17054900 chr3:154042577 DHX36 0.68 11.79 0.42 3.71e-29 Coronary artery disease; BRCA cis rs611744 0.647 rs2594357 chr8:109255989 A/G cg21045802 chr8:109455806 TTC35 0.35 8.0 0.3 5.85e-15 Dupuytren's disease; BRCA cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg04166393 chr7:2884313 GNA12 0.41 8.96 0.33 3.58e-18 Height; BRCA cis rs7264396 1.000 rs224437 chr20:34154371 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -9.96 -0.37 8.39e-22 Total cholesterol levels; BRCA cis rs586533 0.881 rs603255 chr11:99499846 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.84 0.39 3e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs713587 0.967 rs10182181 chr2:25150296 C/T cg04586622 chr2:25135609 ADCY3 -0.41 -10.04 -0.37 3.88e-22 Body mass index in non-asthmatics; BRCA cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg03433033 chr1:76189801 ACADM 0.61 11.23 0.41 8.04e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1580019 0.922 rs34545272 chr7:32460630 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.41 8.76 0.33 1.81e-17 Cognitive ability; BRCA cis rs9325144 0.723 rs11169518 chr12:39177237 C/A cg26384229 chr12:38710491 ALG10B -0.51 -11.47 -0.41 8.36e-28 Morning vs. evening chronotype; BRCA cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg08917208 chr2:24149416 ATAD2B 0.53 8.33 0.31 5.01e-16 Asthma; BRCA cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg01475377 chr6:109611718 NA 0.61 16.92 0.56 2.31e-53 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 8.15e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg26384229 chr12:38710491 ALG10B 0.65 13.91 0.48 1.34e-38 Morning vs. evening chronotype; BRCA cis rs7944584 0.632 rs11039159 chr11:47294021 G/T cg20307385 chr11:47447363 PSMC3 0.57 11.41 0.41 1.42e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg17294928 chr15:75287854 SCAMP5 -0.75 -16.42 -0.54 7.94e-51 Blood trace element (Zn levels); BRCA cis rs908922 0.676 rs1970283 chr1:152495619 G/C cg20991723 chr1:152506922 NA 0.38 8.62 0.32 5.36e-17 Hair morphology; BRCA cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg14349672 chr11:133703707 NA -0.41 -9.09 -0.34 1.23e-18 Childhood ear infection; BRCA cis rs11249608 0.548 rs12152869 chr5:178462520 A/G cg21905437 chr5:178450457 ZNF879 0.51 10.64 0.39 1.95e-24 Pubertal anthropometrics; BRCA cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg05623727 chr3:50126028 RBM5 -0.42 -9.96 -0.37 8.18e-22 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs12133129 chr1:46373348 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg12386194 chr3:101231763 SENP7 0.45 9.52 0.35 3.64e-20 Colorectal cancer; BRCA cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.2 0.34 5.04e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs2270927 0.510 rs4566771 chr5:75576522 C/T cg13563193 chr19:33072644 PDCD5 0.85 10.08 0.37 2.72e-22 Mean corpuscular volume; BRCA cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg13319975 chr6:146136371 FBXO30 0.41 9.44 0.35 7.04e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs55692411 0.537 rs62262118 chr3:50003586 G/A cg24110177 chr3:50126178 RBM5 -0.44 -9.81 -0.36 3.06e-21 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg03188948 chr7:1209495 NA 0.69 11.64 0.42 1.59e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg21770322 chr7:97807741 LMTK2 0.41 10.95 0.4 1.09e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.45 0.38 1.07e-23 Motion sickness; BRCA cis rs3768617 0.811 rs4285667 chr1:182970225 T/A ch.1.3577855R chr1:183094577 LAMC1 0.44 9.77 0.36 4.24e-21 Fuchs's corneal dystrophy; BRCA cis rs1775715 0.678 rs2105360 chr10:32210198 C/T cg14930904 chr10:32216787 ARHGAP12 0.34 7.84 0.3 1.95e-14 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs2839186 0.967 rs2839191 chr21:47695395 C/G cg12379764 chr21:47803548 PCNT -0.39 -8.54 -0.32 1.01e-16 Testicular germ cell tumor; BRCA cis rs4588572 0.688 rs2115436 chr5:77692617 A/T cg11547950 chr5:77652471 NA -0.43 -8.48 -0.32 1.56e-16 Triglycerides; BRCA cis rs7264396 0.580 rs2425181 chr20:34447709 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -12.04 -0.43 3.17e-30 Total cholesterol levels; BRCA cis rs6028335 0.674 rs66526549 chr20:37588360 A/G cg16355469 chr20:37678765 NA 0.46 8.02 0.3 5.2e-15 Alcohol and nicotine co-dependence; BRCA cis rs1891275 0.515 rs7911755 chr10:93489817 G/A cg07889827 chr10:93443413 NA -0.4 -11.0 -0.4 6.64e-26 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.576 rs66671308 chr3:125793526 T/G cg04553112 chr3:125709451 NA -0.55 -8.36 -0.31 4.02e-16 Blood pressure (smoking interaction); BRCA cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg12365402 chr11:9010492 NRIP3 -0.37 -8.43 -0.32 2.34e-16 Hemoglobin concentration; BRCA cis rs9649465 0.561 rs688242 chr7:123420442 C/A cg03229431 chr7:123269106 ASB15 0.42 9.54 0.35 2.95e-20 Migraine; BRCA cis rs2230307 0.656 rs114775204 chr1:100463030 T/C cg24955406 chr1:100503596 HIAT1 0.54 9.42 0.35 8.29e-20 Carotid intima media thickness; BRCA cis rs7945705 0.935 rs2568061 chr11:8886260 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.83 -0.51 5.73e-43 Hemoglobin concentration; BRCA cis rs7178424 0.875 rs28411984 chr15:62221592 A/C cg00456672 chr15:62358751 C2CD4A 0.4 8.9 0.33 5.86e-18 Height; BRCA cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg24558204 chr6:135376177 HBS1L -0.43 -11.73 -0.42 6.32e-29 Red blood cell count; BRCA cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg16339924 chr4:17578868 LAP3 0.56 13.9 0.48 1.42e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4662945 0.603 rs13002385 chr2:130276865 T/C cg05903289 chr2:130345205 NA -0.34 -8.54 -0.32 1.01e-16 Response to cytidine analogues (gemcitabine); BRCA cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg21918786 chr6:109611834 NA -0.46 -12.99 -0.46 2.13e-34 Reticulocyte fraction of red cells; BRCA cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg07395648 chr5:131743802 NA 0.4 9.69 0.36 8.07e-21 Blood metabolite levels; BRCA cis rs524281 0.861 rs3825067 chr11:65878419 A/G cg16950941 chr11:66035639 RAB1B 0.39 8.19 0.31 1.47e-15 Electroencephalogram traits; BRCA cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg23422044 chr7:1970798 MAD1L1 -0.72 -13.3 -0.47 8.72e-36 Bipolar disorder; BRCA cis rs9393777 0.623 rs34313099 chr6:26489607 C/T cg12826209 chr6:26865740 GUSBL1 0.55 9.0 0.34 2.5e-18 Intelligence (multi-trait analysis); BRCA trans rs7615952 0.641 rs7618515 chr3:125790578 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -11.15 -0.4 1.72e-26 Blood pressure (smoking interaction); BRCA cis rs7903847 0.673 rs3818908 chr10:99132701 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.7 -0.33 2.8e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.85 0.53 5.57e-48 Platelet count; BRCA trans rs12310956 0.510 rs4931743 chr12:33867588 T/C cg26384229 chr12:38710491 ALG10B 0.39 9.14 0.34 8.42e-19 Morning vs. evening chronotype; BRCA cis rs7677751 0.806 rs1800812 chr4:55094629 G/T cg17187183 chr4:55093834 PDGFRA 0.44 9.03 0.34 2.03e-18 Corneal astigmatism; BRCA cis rs1018836 0.923 rs756569 chr8:91610957 G/A cg16814680 chr8:91681699 NA -0.58 -12.38 -0.44 1.07e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg24642439 chr20:33292090 TP53INP2 -0.54 -11.59 -0.42 2.5e-28 Glomerular filtration rate (creatinine); BRCA cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg06713675 chr4:122721982 EXOSC9 -0.55 -13.03 -0.46 1.45e-34 Type 2 diabetes; BRCA cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg08754478 chr10:133766260 PPP2R2D -0.67 -13.67 -0.48 1.7e-37 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4242434 0.698 rs10104039 chr8:22538384 A/G cg03733263 chr8:22462867 KIAA1967 -0.66 -14.76 -0.5 1.16e-42 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs11190604 0.767 rs79106148 chr10:102184732 G/A cg07080220 chr10:102295463 HIF1AN 0.49 10.12 0.37 1.96e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.53 -0.35 3.34e-20 Developmental language disorder (linguistic errors); BRCA cis rs7178424 0.967 rs12440524 chr15:62369507 T/C cg00456672 chr15:62358751 C2CD4A -0.42 -9.48 -0.35 4.81e-20 Height; BRCA cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg24549020 chr5:56110836 MAP3K1 0.41 8.56 0.32 8.17e-17 Initial pursuit acceleration; BRCA cis rs2637030 0.515 rs256103 chr5:53012475 A/G cg06476337 chr5:52856530 NDUFS4 0.35 7.92 0.3 1.04e-14 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs2832077 0.527 rs2705690 chr21:30239245 T/A cg08807101 chr21:30365312 RNF160 0.5 11.15 0.4 1.64e-26 Cognitive test performance; BRCA cis rs477692 0.673 rs10764889 chr10:131341521 G/A cg05714579 chr10:131428358 MGMT 0.48 10.36 0.38 2.4e-23 Response to temozolomide; BRCA trans rs61931739 0.500 rs7311284 chr12:34478477 C/G cg13010199 chr12:38710504 ALG10B 0.48 9.56 0.35 2.45e-20 Morning vs. evening chronotype; BRCA cis rs2014572 0.967 rs10413037 chr19:57771883 A/G cg24459738 chr19:57751996 ZNF805 -0.35 -8.06 -0.3 3.63e-15 Hyperactive-impulsive symptoms; BRCA trans rs853679 0.607 rs67998226 chr6:28238059 T/C cg01620082 chr3:125678407 NA -0.87 -10.59 -0.39 2.87e-24 Depression; BRCA cis rs2404602 0.647 rs11072619 chr15:77043242 A/C cg23625390 chr15:77176239 SCAPER -0.55 -13.86 -0.48 2.21e-38 Blood metabolite levels; BRCA cis rs9467773 1.000 rs6932156 chr6:26571506 T/G cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.93e-21 Intelligence (multi-trait analysis); BRCA cis rs992157 0.764 rs4672886 chr2:219185545 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.45 -9.47 -0.35 5.36e-20 Colorectal cancer; BRCA cis rs67981189 0.896 rs34731365 chr14:71449594 C/T cg15816911 chr14:71606274 NA 0.35 7.83 0.3 2.02e-14 Schizophrenia; BRCA cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg21770322 chr7:97807741 LMTK2 0.41 10.87 0.4 2.17e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg12219531 chr12:120966889 COQ5 0.54 11.66 0.42 1.29e-28 High light scatter reticulocyte count; BRCA trans rs9329221 0.662 rs9650650 chr8:10247976 C/T cg15556689 chr8:8085844 FLJ10661 0.35 8.6 0.32 6.04e-17 Neuroticism; BRCA cis rs1048238 0.818 rs945421 chr1:16345393 T/C cg06159980 chr1:16340746 HSPB7 -0.39 -8.86 -0.33 7.77e-18 Systolic blood pressure; BRCA cis rs921968 0.541 rs4674308 chr2:219310483 A/C cg10223061 chr2:219282414 VIL1 -0.27 -8.07 -0.3 3.41e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs6831352 0.877 rs2602890 chr4:100043179 C/T cg12011299 chr4:100065546 ADH4 0.5 11.51 0.41 5.61e-28 Alcohol dependence; BRCA cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg00530320 chr1:46809349 NSUN4 -0.47 -9.45 -0.35 6.31e-20 Menopause (age at onset); BRCA cis rs9818758 0.607 rs55873331 chr3:49597055 C/T cg00383909 chr3:49044727 WDR6 0.89 12.83 0.45 1.12e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1797081 0.542 rs2603796 chr10:16871456 C/T cg23933602 chr10:16859644 RSU1 0.6 14.47 0.5 3.03e-41 Platelet distribution width; BRCA cis rs10911232 0.507 rs12037585 chr1:183000041 G/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.42e-39 Lymphocyte counts; BRCA cis rs7639513 0.767 rs9861472 chr3:12707776 A/T cg23032965 chr3:12705835 RAF1 -0.69 -15.16 -0.51 1.36e-44 Itch intensity from mosquito bite; BRCA cis rs1451375 0.617 rs2329366 chr7:50544966 G/A cg18232548 chr7:50535776 DDC -0.42 -8.87 -0.33 7.23e-18 Malaria; BRCA cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.41 0.38 1.45e-23 Bladder cancer; BRCA trans rs208520 0.545 rs10944874 chr6:66752080 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -27.79 -0.74 4.91e-112 Exhaled nitric oxide output; BRCA cis rs929596 0.755 rs3771341 chr2:234673239 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -11.93 -0.43 9.54e-30 Total bilirubin levels in HIV-1 infection; BRCA cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.13e-15 Tonsillectomy; BRCA cis rs10883723 0.737 rs7074444 chr10:104249922 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 19.18 0.6 4.26e-65 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg17330251 chr7:94953956 PON1 -0.4 -8.54 -0.32 9.69e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs490234 0.702 rs35129945 chr9:128320134 C/T cg14078157 chr9:128172775 NA -0.51 -11.39 -0.41 1.77e-27 Mean arterial pressure; BRCA cis rs11718455 0.960 rs4682713 chr3:44013191 G/C cg08738300 chr3:44038990 NA 0.47 8.84 0.33 9.23e-18 Coronary artery disease; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26314531 chr2:26401878 FAM59B -0.96 -16.08 -0.54 4.13e-49 Gut microbiome composition (summer); BRCA cis rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05901451 chr6:126070800 HEY2 0.4 9.79 0.36 3.51e-21 Endometrial cancer; BRCA cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs10504073 0.584 rs7823690 chr8:49943831 G/A cg00325661 chr8:49890786 NA 0.45 13.13 0.46 4.96e-35 Blood metabolite ratios; BRCA cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg21951975 chr1:209979733 IRF6 0.4 9.26 0.34 2.98e-19 Cleft lip with or without cleft palate; BRCA cis rs2108225 0.967 rs7785790 chr7:107449896 C/T cg18560240 chr7:107437656 SLC26A3 0.52 10.81 0.39 3.96e-25 Ulcerative colitis; BRCA cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.83 -0.42 2.34e-29 Personality dimensions; BRCA cis rs6866344 0.697 rs17184302 chr5:178127676 C/T cg03877680 chr5:178157825 ZNF354A 0.78 14.44 0.5 3.96e-41 Neutrophil percentage of white cells; BRCA cis rs7927771 0.524 rs7118747 chr11:47889545 C/T cg20307385 chr11:47447363 PSMC3 -0.39 -9.29 -0.34 2.38e-19 Subjective well-being; BRCA cis rs17095355 1.000 rs734164 chr10:111698160 C/T cg00817464 chr10:111662876 XPNPEP1 -0.4 -10.36 -0.38 2.34e-23 Biliary atresia; BRCA cis rs10046574 0.516 rs7802453 chr7:135200638 T/C cg27474649 chr7:135195673 CNOT4 0.67 11.09 0.4 3.01e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg24130564 chr14:104152367 KLC1 0.35 7.98 0.3 6.97e-15 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg25036284 chr2:26402008 FAM59B 0.96 16.03 0.54 7.08e-49 Gut microbiome composition (summer); BRCA cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg12698349 chr2:225449008 CUL3 0.59 12.7 0.45 4.29e-33 IgE levels in asthmatics (D.p. specific); BRCA cis rs7412746 0.634 rs7521592 chr1:150821691 A/C cg17724175 chr1:150552817 MCL1 0.25 7.88 0.3 1.46e-14 Melanoma; BRCA cis rs11098499 0.754 rs938056 chr4:120237453 C/T cg09307838 chr4:120376055 NA 0.62 13.08 0.46 8.24e-35 Corneal astigmatism; BRCA cis rs10754283 0.934 rs6684676 chr1:90102173 C/T cg21401794 chr1:90099060 LRRC8C 0.46 11.11 0.4 2.33e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg05890377 chr2:74357713 NA 0.49 11.8 0.42 3.18e-29 Gestational age at birth (maternal effect); BRCA cis rs7786808 0.649 rs1377374 chr7:158215647 G/T cg01191920 chr7:158217561 PTPRN2 0.33 8.12 0.31 2.42e-15 Obesity-related traits; BRCA cis rs67460515 0.596 rs35127376 chr3:160927289 T/C cg17135325 chr3:160939158 NMD3 0.45 8.4 0.32 2.9e-16 Parkinson's disease; BRCA cis rs7100689 0.622 rs2994389 chr10:82062257 C/G cg00277334 chr10:82204260 NA -0.42 -8.23 -0.31 1.04e-15 Post bronchodilator FEV1; BRCA cis rs4713118 0.869 rs7776351 chr6:27726731 A/G cg26587870 chr6:27730563 NA 0.41 8.72 0.33 2.46e-17 Parkinson's disease; BRCA trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.39 9.11 0.34 1.06e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1983170 0.935 rs578155 chr1:91976541 G/A cg25838465 chr1:92012736 NA -0.47 -9.41 -0.35 8.95e-20 Eosinophil percentage of white cells; BRCA cis rs701145 0.585 rs1727893 chr3:153849866 A/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs10193935 0.901 rs6727657 chr2:42632117 A/G cg27598129 chr2:42591480 NA -0.72 -12.7 -0.45 4.13e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg13319975 chr6:146136371 FBXO30 -0.35 -8.11 -0.31 2.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1505368 0.789 rs13419353 chr2:213271459 A/T cg20637307 chr2:213403960 ERBB4 -0.37 -8.94 -0.33 4.03e-18 Symmetrical dimethylarginine levels; BRCA cis rs11585357 0.947 rs3003441 chr1:17611869 C/T cg08277548 chr1:17600880 PADI3 0.6 10.9 0.4 1.69e-25 Hair shape; BRCA cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg12751644 chr20:60527061 NA -0.33 -7.95 -0.3 8.19e-15 Body mass index; BRCA trans rs6598955 0.671 rs11247905 chr1:26627907 G/C cg07461501 chr17:79650226 HGS;ARL16 -0.64 -15.27 -0.52 4.23e-45 Obesity-related traits; BRCA cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg19318889 chr4:1322082 MAEA 0.35 7.99 0.3 6.36e-15 Longevity; BRCA cis rs7267979 1.000 rs2424712 chr20:25416942 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1511802 0.666 rs4862663 chr4:187119228 T/A cg24794857 chr4:187113578 CYP4V2 0.38 8.27 0.31 7.56e-16 Blood protein levels; BRCA cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -15.85 -0.53 6.14e-48 Systemic lupus erythematosus; BRCA cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.84 0.36 2.21e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg17845761 chr1:175162550 KIAA0040 0.27 10.26 0.38 5.52e-23 Alcohol dependence; BRCA cis rs61931739 0.534 rs1211286 chr12:34135581 T/C cg06521331 chr12:34319734 NA -0.61 -12.02 -0.43 3.63e-30 Morning vs. evening chronotype; BRCA cis rs11072804 1 rs11072804 chr15:79078486 T/G cg04896959 chr15:78267971 NA 0.37 8.63 0.32 4.8e-17 Post bronchodilator FEV1/FVC ratio; BRCA cis rs208515 0.525 rs10944859 chr6:66665197 A/G cg07460842 chr6:66804631 NA 0.85 15.31 0.52 2.76e-45 Exhaled nitric oxide levels; BRCA cis rs13064411 0.518 rs7646188 chr3:113219272 C/T cg18753928 chr3:113234510 CCDC52 -0.41 -9.15 -0.34 7.7e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA trans rs9467711 0.606 rs2076030 chr6:26426856 G/A cg01620082 chr3:125678407 NA -0.63 -8.39 -0.32 3.12e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6964587 1.000 rs6465347 chr7:91693837 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs473651 1.000 rs473651 chr2:239335401 A/C cg21699342 chr2:239360505 ASB1 0.53 14.05 0.49 2.92e-39 Multiple system atrophy; BRCA cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg10523679 chr1:76189770 ACADM 0.76 15.75 0.53 1.89e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4237845 0.773 rs6650217 chr12:58289072 T/G cg00677455 chr12:58241039 CTDSP2 0.47 11.51 0.41 5.58e-28 Intelligence (multi-trait analysis); BRCA cis rs10463316 0.894 rs10476980 chr5:150764157 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.4 -0.32 2.96e-16 Metabolite levels (Pyroglutamine); BRCA cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -8.23 -0.31 1.08e-15 Intelligence (multi-trait analysis); BRCA cis rs57221529 0.766 rs72703065 chr5:588123 C/A cg09021430 chr5:549028 NA -0.68 -14.14 -0.49 1.07e-39 Lung disease severity in cystic fibrosis; BRCA cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg05340658 chr4:99064831 C4orf37 0.64 15.51 0.52 2.73e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg08859206 chr1:53392774 SCP2 0.66 13.75 0.48 6.86e-38 Monocyte count; BRCA trans rs1493916 0.837 rs2172626 chr18:31410478 C/T cg15819921 chr19:927150 ARID3A -0.41 -8.07 -0.3 3.37e-15 Life satisfaction; BRCA cis rs3857067 0.773 rs2865344 chr4:95103040 C/T cg11021082 chr4:95130006 SMARCAD1 -0.38 -8.83 -0.33 1.01e-17 QT interval; BRCA cis rs9287719 0.870 rs10167676 chr2:10753140 G/A cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg13073564 chr4:8508604 NA 0.43 11.82 0.42 2.72e-29 Response to antineoplastic agents; BRCA trans rs61931739 0.500 rs11053199 chr12:34450534 C/T cg26384229 chr12:38710491 ALG10B -0.57 -12.91 -0.45 4.64e-34 Morning vs. evening chronotype; BRCA cis rs897080 0.515 rs1067401 chr2:44676541 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.43 0.32 2.24e-16 Height; BRCA cis rs40363 0.645 rs250627 chr16:3527050 G/A cg22508957 chr16:3507546 NAT15 0.45 10.65 0.39 1.68e-24 Tuberculosis; BRCA cis rs3925075 0.525 rs929868 chr16:31280282 G/A cg02846316 chr16:31340340 ITGAM 0.43 8.78 0.33 1.55e-17 IgA nephropathy; BRCA cis rs2625529 0.701 rs62025574 chr15:72236075 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.27 -0.56 3.79e-55 Red blood cell count; BRCA cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg18132916 chr6:79620363 NA 0.48 10.99 0.4 7.19e-26 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg01262667 chr19:19385393 TM6SF2 0.42 10.96 0.4 9.96e-26 Tonsillectomy; BRCA cis rs11031096 0.782 rs10767845 chr11:4156922 C/T cg18678763 chr11:4115507 RRM1 -0.38 -8.58 -0.32 7.01e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg00166722 chr3:10149974 C3orf24 0.64 11.32 0.41 3.47e-27 Alzheimer's disease; BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.06 -0.3 3.67e-15 Total body bone mineral density; BRCA cis rs10782582 0.593 rs6675076 chr1:76118503 A/C cg03433033 chr1:76189801 ACADM -0.49 -10.05 -0.37 3.79e-22 Daytime sleep phenotypes; BRCA cis rs9858542 0.953 rs7622302 chr3:49547561 T/C cg07274523 chr3:49395745 GPX1 0.46 7.92 0.3 1.07e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7131987 0.650 rs67146951 chr12:29450553 C/A cg09582351 chr12:29534625 ERGIC2 -0.47 -10.87 -0.39 2.36e-25 QT interval; BRCA cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg22875332 chr1:76189707 ACADM 0.79 18.87 0.6 1.86e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12464559 0.522 rs4414677 chr2:152624932 A/C cg01189475 chr2:152685088 ARL5A -0.58 -8.92 -0.33 5.06e-18 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs1400816 0.850 rs16859721 chr2:172536172 A/G cg13550731 chr2:172543902 DYNC1I2 0.51 7.89 0.3 1.34e-14 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg17366294 chr4:99064904 C4orf37 0.41 9.64 0.36 1.23e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg18904891 chr8:8559673 CLDN23 0.66 13.13 0.46 4.67e-35 Obesity-related traits; BRCA cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg11993925 chr19:44307056 LYPD5 0.51 11.3 0.41 4.02e-27 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg08999081 chr20:33150536 PIGU 0.36 9.21 0.34 4.64e-19 Coronary artery disease; BRCA trans rs561341 0.783 rs512698 chr17:30292507 G/T cg27661571 chr11:113659931 NA -0.7 -10.82 -0.39 3.5e-25 Hip circumference adjusted for BMI; BRCA cis rs1577917 1.000 rs12216203 chr6:86675301 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.01 -0.3 5.62e-15 Response to antipsychotic treatment; BRCA cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.84 0.3 1.95e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg23711669 chr6:146136114 FBXO30 0.74 15.93 0.53 2.41e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.56 -0.35 2.5e-20 Developmental language disorder (linguistic errors); BRCA cis rs6496044 0.547 rs7173125 chr15:86055445 C/G cg10818794 chr15:86012489 AKAP13 0.3 8.09 0.3 2.98e-15 Interstitial lung disease; BRCA cis rs654351 0.541 rs533746 chr6:10388968 C/T cg04978078 chr6:10383147 NA 0.43 8.36 0.31 3.83e-16 Squamous cell lung carcinoma; BRCA cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2652834 1.000 rs2652834 chr15:63396867 A/G cg05507819 chr15:63340323 TPM1 0.44 8.08 0.3 3.16e-15 HDL cholesterol; BRCA cis rs2304069 1.000 rs10072275 chr5:149401596 T/C cg10852222 chr5:149380144 HMGXB3;TIGD6 0.49 7.92 0.3 1.07e-14 HIV-1 control; BRCA cis rs9287719 0.967 rs11674433 chr2:10730839 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.09 -0.3 3.04e-15 Prostate cancer; BRCA trans rs7980799 0.716 rs1351683 chr12:33598563 G/A cg26384229 chr12:38710491 ALG10B -0.52 -11.03 -0.4 5.03e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs250677 0.522 rs1007400 chr5:148382635 C/T cg18129178 chr5:148520854 ABLIM3 0.55 10.69 0.39 1.2e-24 Breast cancer; BRCA trans rs4332037 0.901 rs7791299 chr7:1935598 T/C cg25206134 chr2:45395956 NA 0.41 7.84 0.3 1.9e-14 Bipolar disorder; BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.35 0.35 1.49e-19 Tonsillectomy; BRCA cis rs858239 0.730 rs10255155 chr7:23402147 A/T cg23682824 chr7:23144976 KLHL7 -0.31 -8.06 -0.3 3.72e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs7172677 0.737 rs7169545 chr15:75436123 A/G cg14664628 chr15:75095509 CSK -0.38 -8.02 -0.3 5.21e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs10911363 0.592 rs2702180 chr1:183517971 T/C cg09173681 chr1:183549694 NCF2 0.48 10.19 0.37 1.03e-22 Systemic lupus erythematosus; BRCA cis rs8114671 0.904 rs6060197 chr20:33654315 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.52 -0.32 1.12e-16 Height; BRCA cis rs9640161 0.659 rs77354576 chr7:150013300 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.51 -13.02 -0.46 1.53e-34 Blood protein levels;Circulating chemerin levels; BRCA cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.14 0.4 1.78e-26 Schizophrenia; BRCA cis rs853679 0.517 rs9357066 chr6:28129831 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.57e-15 Depression; BRCA trans rs4650994 1.000 rs4650999 chr1:178532188 A/C cg05059571 chr16:84539110 KIAA1609 0.37 8.55 0.32 8.92e-17 HDL cholesterol levels;HDL cholesterol; BRCA cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg01448562 chr3:133502909 NA -0.5 -10.86 -0.39 2.6e-25 Iron status biomarkers; BRCA cis rs77106637 0.932 rs2886599 chr11:72721271 C/A cg03713592 chr11:72463424 ARAP1 0.83 12.32 0.44 1.99e-31 Type 2 diabetes; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg04267008 chr7:1944627 MAD1L1 -0.65 -13.96 -0.48 7.8e-39 Bipolar disorder and schizophrenia; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg07092213 chr7:1199455 ZFAND2A -0.42 -8.26 -0.31 8.52e-16 Longevity;Endometriosis; BRCA cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg10523679 chr1:76189770 ACADM 0.77 15.94 0.53 2.03e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.9 0.33 5.51e-18 Tonsillectomy; BRCA cis rs698813 0.674 rs6544751 chr2:44495845 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.7 0.33 2.82e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg11168104 chr5:1857477 NA -0.32 -8.17 -0.31 1.63e-15 Cardiovascular disease risk factors; BRCA cis rs2016266 0.859 rs4759061 chr12:53738214 C/T cg26875137 chr12:53738046 NA -0.46 -10.16 -0.37 1.38e-22 Bone mineral density (spine);Bone mineral density; BRCA cis rs7666738 0.716 rs9994641 chr4:99101605 C/T cg05340658 chr4:99064831 C4orf37 0.63 14.57 0.5 9.57e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs10911363 0.570 rs2702204 chr1:183457396 A/G cg09173681 chr1:183549694 NCF2 0.54 11.31 0.41 3.61e-27 Systemic lupus erythematosus; BRCA trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg23533926 chr12:111358616 MYL2 -0.41 -8.54 -0.32 9.72e-17 Extrinsic epigenetic age acceleration; BRCA trans rs3780486 0.881 rs10738906 chr9:33135634 T/C cg20290983 chr6:43655470 MRPS18A 1.1 40.32 0.85 9.69e-178 IgG glycosylation; BRCA trans rs208520 0.690 rs12189780 chr6:66759619 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 20.85 0.64 4.63e-74 Exhaled nitric oxide output; BRCA cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg15556689 chr8:8085844 FLJ10661 -0.4 -11.36 -0.41 2.22e-27 Systolic blood pressure; BRCA trans rs6461049 0.734 rs1558465 chr7:2151398 G/C cg04565464 chr8:145669602 NFKBIL2 0.45 10.86 0.39 2.57e-25 Schizophrenia; BRCA cis rs9527 1.000 rs9527 chr10:104623578 C/T cg04362960 chr10:104952993 NT5C2 0.53 11.0 0.4 7.09e-26 Arsenic metabolism; BRCA cis rs7085104 0.727 rs12773892 chr10:104631177 G/T cg04362960 chr10:104952993 NT5C2 0.74 12.68 0.45 5.21e-33 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.52 -0.32 1.18e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg13010199 chr12:38710504 ALG10B -0.39 -8.7 -0.33 2.87e-17 Morning vs. evening chronotype; BRCA cis rs11112613 0.713 rs2374502 chr12:105938939 T/C cg03607813 chr12:105948248 NA 0.59 10.95 0.4 1.1e-25 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs7267979 1.000 rs2259873 chr20:25280781 A/G cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17376456 0.825 rs10054790 chr5:93272520 A/G cg25358565 chr5:93447407 FAM172A 1.22 18.72 0.6 1.12e-62 Diabetic retinopathy; BRCA cis rs9291683 0.588 rs17246745 chr4:9994583 T/C cg00071950 chr4:10020882 SLC2A9 0.59 14.75 0.5 1.35e-42 Bone mineral density; BRCA cis rs2625529 0.617 rs8557 chr15:72115733 T/C cg16672083 chr15:72433130 SENP8 -0.64 -15.07 -0.51 4.06e-44 Red blood cell count; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg15112475 chr7:1198522 ZFAND2A -0.39 -8.37 -0.31 3.69e-16 Longevity;Endometriosis; BRCA trans rs61931739 0.534 rs12372721 chr12:34175301 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.74 0.36 5.46e-21 Morning vs. evening chronotype; BRCA cis rs6840360 0.593 rs10013612 chr4:152693622 A/G cg22705602 chr4:152727874 NA -0.38 -10.58 -0.39 3.14e-24 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg25358565 chr5:93447407 FAM172A 1.16 18.45 0.59 2.99e-61 Diabetic retinopathy; BRCA cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.73 21.45 0.65 2.56e-77 Age-related macular degeneration (geographic atrophy); BRCA cis rs10193935 0.901 rs1390609 chr2:42666230 G/T cg27598129 chr2:42591480 NA 0.8 13.48 0.47 1.24e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg17211192 chr8:82754475 SNX16 -0.49 -11.13 -0.4 1.94e-26 Diastolic blood pressure; BRCA cis rs1580019 0.537 rs7804609 chr7:32558094 A/C cg06627557 chr7:32535165 LSM5;AVL9 1.05 28.7 0.75 5.06e-117 Cognitive ability; BRCA cis rs6570726 0.791 rs621382 chr6:145799144 T/C cg23711669 chr6:146136114 FBXO30 0.76 17.27 0.56 3.72e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs7683537 0.673 rs1401363 chr4:185643862 A/G cg04058563 chr4:185651563 MLF1IP 0.76 16.78 0.55 1.26e-52 Systemic lupus erythematosus; BRCA cis rs7631605 0.586 rs62241896 chr3:37368755 T/A cg15934958 chr3:37212084 LRRFIP2 0.38 8.09 0.3 2.95e-15 Cerebrospinal P-tau181p levels; BRCA cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg24812749 chr6:127587940 RNF146 0.89 20.86 0.64 4.5e-74 Breast cancer; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 18.56 0.59 7.75e-62 Alzheimer's disease; BRCA cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg22496339 chr2:162101262 NA -0.39 -8.13 -0.31 2.26e-15 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs9393777 0.623 rs3734544 chr6:26468660 G/A cg12826209 chr6:26865740 GUSBL1 0.56 9.22 0.34 4.42e-19 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.874 rs4675133 chr2:227843010 A/G cg11843606 chr2:227700838 RHBDD1 0.37 8.15 0.31 1.86e-15 Pulmonary function; BRCA cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.45e-19 Bipolar disorder; BRCA cis rs6743226 0.870 rs4675966 chr2:242244342 T/C cg10021735 chr2:242295487 FARP2 0.37 10.03 0.37 4.43e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs7903847 0.620 rs10882904 chr10:99115683 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.11 -0.31 2.62e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs3815308 0.530 rs12973409 chr19:2196963 A/G cg09261902 chr19:2140048 AP3D1 0.34 8.25 0.31 9.09e-16 Breast cancer; BRCA cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg01884057 chr2:25150051 NA 0.31 8.14 0.31 2.14e-15 Body mass index; BRCA trans rs629535 0.590 rs56200825 chr8:70123450 G/A cg21567404 chr3:27674614 NA -0.97 -17.77 -0.58 1.09e-57 Dupuytren's disease; BRCA cis rs17620991 1.000 rs17620991 chr7:40836521 G/C cg05119115 chr7:40866195 C7orf10 -0.56 -8.71 -0.33 2.66e-17 Alcohol dependence; BRCA cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg08975724 chr8:8085496 FLJ10661 0.38 8.37 0.31 3.52e-16 Mood instability; BRCA cis rs5167 0.504 rs3760625 chr19:45456941 G/A cg13119609 chr19:45449297 APOC2 0.48 13.29 0.47 9.51e-36 Blood protein levels; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg04025307 chr7:1156635 C7orf50 0.6 10.36 0.38 2.27e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9467773 0.869 rs1796521 chr6:26421392 T/C cg09904177 chr6:26538194 HMGN4 -0.47 -13.47 -0.47 1.37e-36 Intelligence (multi-trait analysis); BRCA cis rs4478137 0.824 rs4691905 chr4:164221437 T/C cg06758707 chr4:164254230 NPY1R 0.57 12.29 0.44 2.57e-31 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg14582100 chr15:45693742 SPATA5L1 0.37 11.85 0.42 2.07e-29 Homoarginine levels; BRCA cis rs796364 0.806 rs74938253 chr2:201008386 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.54 -8.52 -0.32 1.1e-16 Schizophrenia; BRCA cis rs10795061 0.576 rs6601744 chr10:3711563 C/A cg22632523 chr10:3711048 NA 0.43 10.04 0.37 4.12e-22 Subjective well-being; BRCA cis rs6840360 0.593 rs1877185 chr4:152690348 C/T cg22705602 chr4:152727874 NA -0.36 -9.79 -0.36 3.38e-21 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg22907277 chr7:1156413 C7orf50 0.6 11.41 0.41 1.46e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg15704280 chr7:45808275 SEPT13 0.69 14.18 0.49 6.74e-40 Height; BRCA cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.64 13.44 0.47 1.87e-36 Hip circumference adjusted for BMI; BRCA trans rs60843830 0.661 rs11674477 chr2:105822 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.47 9.24 0.34 3.69e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs35110281 0.659 rs2236667 chr21:45112939 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.23 0.31 1.07e-15 Mean corpuscular volume; BRCA cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg23283495 chr1:209979779 IRF6 0.39 9.19 0.34 5.38e-19 Cleft lip with or without cleft palate; BRCA cis rs7613875 0.620 rs17657664 chr3:50032008 T/G cg24110177 chr3:50126178 RBM5 -0.52 -14.79 -0.51 8.67e-43 Body mass index; BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.19 0.4 1.13e-26 Platelet count; BRCA cis rs6594499 0.872 rs1379298 chr5:110435726 T/C cg04022379 chr5:110408740 TSLP 0.35 8.06 0.3 3.73e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg11189052 chr15:85197271 WDR73 0.44 9.05 0.34 1.66e-18 Schizophrenia; BRCA cis rs4363385 0.720 rs11205150 chr1:152959266 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.82 -0.33 1.06e-17 Inflammatory skin disease; BRCA cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs7726839 0.561 rs72703046 chr5:580129 T/C cg25482853 chr8:67687455 SGK3 0.78 13.01 0.46 1.67e-34 Obesity-related traits; BRCA cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg03146154 chr1:46216737 IPP 0.44 9.84 0.36 2.35e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.31 -8.46 -0.32 1.81e-16 Monocyte percentage of white cells; BRCA cis rs694739 0.628 rs645078 chr11:64135298 A/C cg02228329 chr11:64053129 BAD;GPR137 0.53 11.77 0.42 4.42e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs2230307 0.536 rs7518943 chr1:100463422 G/T cg24955406 chr1:100503596 HIAT1 0.59 11.65 0.42 1.4e-28 Carotid intima media thickness; BRCA cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg06547715 chr2:218990976 CXCR2 0.32 7.94 0.3 9.05e-15 Ulcerative colitis; BRCA cis rs2625529 0.730 rs3759900 chr15:72451827 A/C cg16672083 chr15:72433130 SENP8 0.7 16.8 0.55 9.69e-53 Red blood cell count; BRCA trans rs3780486 0.846 rs10971419 chr9:33124161 T/C cg04842962 chr6:43655489 MRPS18A 1.13 39.0 0.84 3.68e-171 IgG glycosylation; BRCA cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.09 0.4 2.82e-26 Electroencephalogram traits; BRCA cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.9 0.51 2.47e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg00701064 chr4:6280414 WFS1 0.68 18.23 0.58 4.13e-60 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9649213 0.555 rs6955259 chr7:97892356 T/A cg24562669 chr7:97807699 LMTK2 0.47 11.97 0.43 5.95e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.2 0.56 9.47e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg05347473 chr6:146136440 FBXO30 0.4 7.99 0.3 6.36e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg10802521 chr3:52805072 NEK4 -0.33 -8.76 -0.33 1.75e-17 Bipolar disorder; BRCA cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg26248373 chr2:1572462 NA -0.67 -15.83 -0.53 7.21e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.36 0.38 2.41e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg05340658 chr4:99064831 C4orf37 0.63 15.04 0.51 5.63e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs1198430 1.000 rs1198439 chr1:23749593 A/T cg19827787 chr1:23763612 ASAP3 0.35 9.7 0.36 7.71e-21 Total cholesterol levels; BRCA cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg24549020 chr5:56110836 MAP3K1 0.67 13.67 0.48 1.63e-37 Initial pursuit acceleration; BRCA cis rs208520 0.661 rs207111 chr6:66792513 C/T cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg21280719 chr6:42927975 GNMT -0.31 -12.84 -0.45 1.01e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs28374715 0.662 rs111522288 chr15:41480169 C/T cg18705301 chr15:41695430 NDUFAF1 -0.86 -18.17 -0.58 8.71e-60 Ulcerative colitis; BRCA cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg23029597 chr12:123009494 RSRC2 -0.58 -12.04 -0.43 3.07e-30 Body mass index; BRCA cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs4285028 0.699 rs1920297 chr3:121598000 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -13.2 -0.46 2.4e-35 Multiple sclerosis; BRCA cis rs9790314 0.645 rs10936224 chr3:160902531 G/A cg03342759 chr3:160939853 NMD3 -0.61 -14.07 -0.49 2.3e-39 Morning vs. evening chronotype; BRCA cis rs796364 0.951 rs769952 chr2:200734368 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.8 0.42 3.22e-29 Schizophrenia; BRCA cis rs17209837 0.646 rs4148818 chr7:87083738 T/C cg00919237 chr7:87102261 ABCB4 -0.52 -10.19 -0.37 1.03e-22 Gallbladder cancer; BRCA cis rs724568 0.546 rs966443 chr2:67940867 G/A cg14046302 chr2:67939758 NA -0.41 -10.97 -0.4 9.16e-26 Major depressive disorder (broad); BRCA trans rs7746199 0.673 rs35501037 chr6:27739566 T/A cg01620082 chr3:125678407 NA -0.85 -9.89 -0.36 1.52e-21 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs8180040 1.000 rs2302278 chr3:47361082 G/T cg16586182 chr3:47516702 SCAP 0.57 12.97 0.46 2.7e-34 Colorectal cancer; BRCA cis rs17401966 1.000 rs4845934 chr1:10468946 G/A cg03954927 chr1:10346856 KIF1B 0.45 12.41 0.44 7.63e-32 Hepatocellular carcinoma; BRCA cis rs495337 1.000 rs644013 chr20:48515838 T/C cg17835207 chr20:48524531 SPATA2 -0.64 -14.6 -0.5 6.85e-42 Psoriasis; BRCA trans rs2204008 0.555 rs7310307 chr12:38107497 G/T cg06521331 chr12:34319734 NA -0.55 -9.39 -0.35 9.99e-20 Bladder cancer; BRCA trans rs1493916 0.870 rs7239173 chr18:31395534 A/T cg15819921 chr19:927150 ARID3A -0.52 -10.09 -0.37 2.52e-22 Life satisfaction; BRCA trans rs61931739 0.534 rs73103090 chr12:34098801 C/T cg13010199 chr12:38710504 ALG10B 0.46 9.02 0.34 2.17e-18 Morning vs. evening chronotype; BRCA cis rs9768139 0.733 rs13225172 chr7:158120334 G/A cg24154853 chr7:158122151 PTPRN2 0.37 8.18 0.31 1.59e-15 Calcium levels; BRCA cis rs6542838 0.641 rs6704682 chr2:99499602 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.13 -0.34 9.24e-19 Fear of minor pain; BRCA cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.17 -0.34 6.2800000000000005e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs34779708 0.966 rs34776628 chr10:35426324 G/A cg03585969 chr10:35415529 CREM 0.49 10.22 0.37 8.03e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg13047869 chr3:10149882 C3orf24 0.59 12.5 0.44 3.18e-32 Alzheimer's disease; BRCA cis rs7809950 1.000 rs2808 chr7:107260856 A/G cg23024343 chr7:107201750 COG5 0.37 8.46 0.32 1.86e-16 Coronary artery disease; BRCA trans rs3812049 0.784 rs2568928 chr5:127487603 C/T cg16011800 chr17:1958478 HIC1 0.53 8.77 0.33 1.67e-17 Lymphocyte counts;Red cell distribution width; BRCA cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg18132916 chr6:79620363 NA -0.49 -11.12 -0.4 2.12e-26 Intelligence (multi-trait analysis); BRCA cis rs2115630 0.755 rs7169629 chr15:85191274 C/G cg12863693 chr15:85201151 NMB 0.32 7.84 0.3 1.95e-14 P wave terminal force; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6977660 0.714 rs12700075 chr7:19791476 G/T cg05791153 chr7:19748676 TWISTNB 0.62 10.94 0.4 1.21e-25 Thyroid stimulating hormone; BRCA cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg14403583 chr14:105418241 AHNAK2 -0.38 -8.9 -0.33 5.67e-18 Rheumatoid arthritis; BRCA cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg20503657 chr10:835505 NA 1.3 21.17 0.64 8.88e-76 Eosinophil percentage of granulocytes; BRCA trans rs66887589 0.837 rs7661498 chr4:120408108 T/C cg25214090 chr10:38739885 LOC399744 0.35 7.92 0.3 1.04e-14 Diastolic blood pressure; BRCA cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg01689657 chr7:91764605 CYP51A1 -0.22 -7.85 -0.3 1.74e-14 Breast cancer; BRCA cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.7 -0.36 7.54e-21 Developmental language disorder (linguistic errors); BRCA cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg05340658 chr4:99064831 C4orf37 0.59 12.8 0.45 1.47e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg01256987 chr12:42539512 GXYLT1 -0.57 -11.69 -0.42 9.68e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2204008 0.502 rs2387275 chr12:38142836 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.94 0.56 1.95e-53 Bladder cancer; BRCA cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.25 0.34 3.28e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs367943 0.966 rs348947 chr5:112822795 C/G cg12552261 chr5:112820674 MCC -0.55 -12.07 -0.43 2.28e-30 Type 2 diabetes; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg23708337 chr7:1209742 NA 0.64 8.82 0.33 1.09e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7833986 1.000 rs34608229 chr8:57097017 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.3 0.31 6.17e-16 Height; BRCA cis rs9815354 1.000 rs28702390 chr3:41889920 C/A cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs4481887 0.893 rs10888337 chr1:248428227 A/G cg00666640 chr1:248458726 OR2T12 -0.3 -8.8 -0.33 1.28e-17 Common traits (Other); BRCA cis rs6964587 0.967 rs12531966 chr7:91765840 A/G cg17063962 chr7:91808500 NA 0.57 13.14 0.46 4.55e-35 Breast cancer; BRCA cis rs2204008 0.846 rs2030416 chr12:38465118 A/G cg26384229 chr12:38710491 ALG10B -0.62 -14.9 -0.51 2.52e-43 Bladder cancer; BRCA cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg22875332 chr1:76189707 ACADM 0.69 14.27 0.49 2.63e-40 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg04455712 chr21:45112962 RRP1B 0.4 10.68 0.39 1.35e-24 Mean corpuscular volume; BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg04166393 chr7:2884313 GNA12 0.6 12.22 0.44 5.26e-31 Height; BRCA trans rs11098499 0.820 rs11737395 chr4:120520704 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.05 0.3 3.92e-15 Corneal astigmatism; BRCA cis rs7572733 0.534 rs7557203 chr2:198795650 A/G cg00792783 chr2:198669748 PLCL1 0.44 9.71 0.36 6.89e-21 Dermatomyositis; BRCA cis rs2046867 0.818 rs17010188 chr3:72870351 T/C cg25664220 chr3:72788482 NA -0.55 -11.74 -0.42 5.88e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg14835575 chr10:16859367 RSU1 0.64 13.08 0.46 8.16e-35 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs754466 1.000 rs2278218 chr10:79680399 G/A cg17075019 chr10:79541650 NA -0.68 -12.85 -0.45 8.95e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg07138768 chr7:917805 C7orf20 0.29 8.32 0.31 5.13e-16 Perceived unattractiveness to mosquitoes; BRCA cis rs6942756 0.747 rs691435 chr7:129097352 C/T cg02491457 chr7:128862824 NA 0.53 11.08 0.4 3.13e-26 White matter hyperintensity burden; BRCA cis rs921968 0.565 rs3770220 chr2:219619550 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 3.87e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg09184832 chr6:79620586 NA -0.43 -8.6 -0.32 6.25e-17 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg07606381 chr6:8435919 SLC35B3 -0.65 -14.56 -0.5 1.16e-41 Motion sickness; BRCA cis rs708547 0.735 rs1277280 chr4:57866872 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 13.96 0.48 7.17e-39 Response to bleomycin (chromatid breaks); BRCA cis rs1401999 0.966 rs2037379 chr3:183650330 T/C cg01324343 chr3:183735012 ABCC5 0.85 21.53 0.65 1.06e-77 Anterior chamber depth; BRCA trans rs11722228 0.522 rs62286604 chr4:10131161 A/G cg26043149 chr18:55253948 FECH 1.19 27.92 0.74 9.06e-113 Gout;Urate levels;Serum uric acid levels; BRCA cis rs2051211 0.895 rs17037798 chr3:38555474 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.48 -9.46 -0.35 5.86e-20 QRS duration; BRCA cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg26384229 chr12:38710491 ALG10B 0.65 14.21 0.49 5e-40 Morning vs. evening chronotype; BRCA cis rs9463078 0.764 rs9367211 chr6:44885305 T/C cg25276700 chr6:44698697 NA -0.36 -8.3 -0.31 6.38e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs13046373 0.508 rs13048637 chr21:31999055 T/G cg16431978 chr21:31797932 KRTAP13-3 0.35 8.97 0.33 3.31e-18 HDL cholesterol; BRCA cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.9e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7809950 1.000 rs10276604 chr7:107216738 C/T cg23024343 chr7:107201750 COG5 0.37 8.08 0.3 3.24e-15 Coronary artery disease; BRCA cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg13660082 chr14:53194042 PSMC6 -0.55 -8.15 -0.31 1.92e-15 Alzheimer's disease (late onset); BRCA cis rs9467773 0.620 rs2494716 chr6:26662736 T/C cg11502198 chr6:26597334 ABT1 0.56 11.96 0.43 6.82e-30 Intelligence (multi-trait analysis); BRCA cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.12 -0.31 2.39e-15 Total body bone mineral density; BRCA cis rs17376456 0.877 rs10059630 chr5:93459807 C/A cg21475434 chr5:93447410 FAM172A 0.68 9.19 0.34 5.41e-19 Diabetic retinopathy; BRCA cis rs1577917 0.958 rs1545376 chr6:86504582 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 12.28 0.44 2.74e-31 Response to antipsychotic treatment; BRCA cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg20607287 chr7:12443886 VWDE -0.58 -8.36 -0.31 4.04e-16 Coronary artery disease; BRCA cis rs250677 0.687 rs250679 chr5:148434952 A/T cg18129178 chr5:148520854 ABLIM3 0.58 11.66 0.42 1.25e-28 Breast cancer; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg10819733 chr22:24237672 NA 0.32 8.56 0.32 8.64e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg17366294 chr4:99064904 C4orf37 0.41 9.24 0.34 3.51e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg16405210 chr4:1374714 KIAA1530 -0.59 -13.67 -0.48 1.72e-37 Longevity; BRCA cis rs9297145 0.761 rs112155177 chr7:98747963 C/T cg05967295 chr7:98741636 SMURF1 0.84 15.8 0.53 9.76e-48 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs6963495 0.818 rs6957192 chr7:105150255 A/C cg13798780 chr7:105162888 PUS7 -0.43 -8.08 -0.3 3.16e-15 Bipolar disorder (body mass index interaction); BRCA cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.33 0.49 1.31e-40 Motion sickness; BRCA cis rs743757 1.000 rs734767 chr3:50431410 C/G cg05260129 chr3:50388622 TUSC4;CYB561D2 0.49 8.95 0.33 3.91e-18 Diastolic blood pressure; BRCA cis rs2243480 1.000 rs160642 chr7:65558373 C/T cg18252515 chr7:66147081 NA -1.07 -15.54 -0.52 2.03e-46 Diabetic kidney disease; BRCA cis rs36051895 0.659 rs12339666 chr9:5063296 A/C cg02405213 chr9:5042618 JAK2 0.48 9.31 0.35 1.97e-19 Pediatric autoimmune diseases; BRCA cis rs10197940 0.662 rs6735771 chr2:152273503 G/A cg06191203 chr2:152266755 RIF1 0.31 9.11 0.34 1.08e-18 Lung cancer; BRCA cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg15556689 chr8:8085844 FLJ10661 0.46 13.09 0.46 7.14e-35 Mood instability; BRCA trans rs8073060 0.544 rs17550716 chr17:33893208 A/G cg19694781 chr19:47549865 TMEM160 0.99 21.09 0.64 2.51e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs12310956 0.532 rs11052948 chr12:33981973 T/C cg26384229 chr12:38710491 ALG10B 0.67 14.02 0.49 4.13e-39 Morning vs. evening chronotype; BRCA cis rs877529 1.000 rs139402 chr22:39546145 T/C cg12193277 chr22:39547181 CBX7 0.46 12.59 0.45 1.3e-32 Multiple myeloma; BRCA trans rs1941687 0.563 rs1586987 chr18:31338661 A/G cg15819921 chr19:927150 ARID3A -0.4 -8.11 -0.31 2.56e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs1401999 0.966 rs2313212 chr3:183700928 A/G cg01324343 chr3:183735012 ABCC5 0.85 21.64 0.65 2.62e-78 Anterior chamber depth; BRCA cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.43 0.57 6.27e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.78 0.39 5.36e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg21782813 chr7:2030301 MAD1L1 0.4 10.45 0.38 1.09e-23 Schizophrenia; BRCA cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.574 rs1836856 chr21:44964638 A/T cg01579765 chr21:45077557 HSF2BP -0.37 -9.9 -0.36 1.3e-21 Mean corpuscular volume; BRCA cis rs7246657 0.943 rs7246993 chr19:37890154 C/T cg23950597 chr19:37808831 NA -0.75 -13.01 -0.46 1.65e-34 Coronary artery calcification; BRCA trans rs2204008 0.774 rs11514062 chr12:38332297 A/C cg06521331 chr12:34319734 NA -0.49 -9.37 -0.35 1.23e-19 Bladder cancer; BRCA cis rs6785206 1.000 rs2712370 chr3:128425204 C/G cg16766828 chr3:128327626 NA -0.65 -9.97 -0.37 7.65e-22 Lymphocyte percentage of white cells; BRCA cis rs1953600 1.000 rs1953600 chr10:81911725 A/G cg04850286 chr10:81895943 PLAC9 0.34 9.97 0.37 7.4e-22 Sarcoidosis; BRCA cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.56 -10.79 -0.39 4.95e-25 Response to bleomycin (chromatid breaks); BRCA cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.39 -0.44 9.32e-32 Chronic sinus infection; BRCA cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg19346786 chr7:2764209 NA -0.3 -9.38 -0.35 1.09e-19 Height; BRCA cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg02659138 chr7:134003124 SLC35B4 0.36 11.27 0.41 5.18e-27 Mean platelet volume; BRCA trans rs61931739 0.534 rs1352206 chr12:34036668 G/A cg26384229 chr12:38710491 ALG10B 0.56 12.16 0.43 9.7e-31 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg23788917 chr6:8435910 SLC35B3 -0.48 -10.43 -0.38 1.21e-23 Motion sickness; BRCA cis rs9462027 0.628 rs2492860 chr6:34705530 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA cis rs1059312 0.932 rs4760592 chr12:129287149 G/C cg09035930 chr12:129282057 SLC15A4 0.56 16.18 0.54 1.4e-49 Systemic lupus erythematosus; BRCA cis rs6542838 0.583 rs7565819 chr2:99519265 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -8.91 -0.33 5.14e-18 Fear of minor pain; BRCA cis rs7646881 1.000 rs73015654 chr3:158451654 G/A cg19483011 chr3:158453295 NA -0.49 -9.34 -0.35 1.61e-19 Tetralogy of Fallot; BRCA cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg15017067 chr4:17643749 FAM184B 0.35 11.0 0.4 7.1e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg21573476 chr21:45109991 RRP1B -0.4 -11.05 -0.4 4.27e-26 Mean corpuscular volume; BRCA trans rs4650994 1.000 rs10913572 chr1:178526718 C/T cg05059571 chr16:84539110 KIAA1609 -0.41 -9.22 -0.34 4.12e-19 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7246657 1.000 rs35398388 chr19:37740358 A/G cg18154014 chr19:37997991 ZNF793 0.55 10.28 0.38 4.63e-23 Coronary artery calcification; BRCA cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg14993813 chr1:46806288 NSUN4 -0.47 -9.0 -0.34 2.6e-18 Menopause (age at onset); BRCA cis rs616402 0.564 rs7419116 chr1:10578606 G/A cg17425144 chr1:10567563 PEX14 0.57 15.36 0.52 1.54e-45 Breast size; BRCA cis rs701145 0.938 rs701133 chr3:154070312 A/G cg17054900 chr3:154042577 DHX36 0.66 11.41 0.41 1.46e-27 Coronary artery disease; BRCA cis rs61931739 0.517 rs12816423 chr12:34067736 G/A cg06521331 chr12:34319734 NA -0.62 -11.14 -0.4 1.81e-26 Morning vs. evening chronotype; BRCA cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.56 -11.63 -0.42 1.67e-28 Monocyte percentage of white cells; BRCA cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.4 -0.38 1.59e-23 Initial pursuit acceleration; BRCA cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg09184832 chr6:79620586 NA -0.54 -11.97 -0.43 6.23e-30 Intelligence (multi-trait analysis); BRCA cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg00677455 chr12:58241039 CTDSP2 0.62 14.49 0.5 2.27e-41 Multiple sclerosis; BRCA cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg01579765 chr21:45077557 HSF2BP -0.4 -10.74 -0.39 7.44e-25 Mean corpuscular volume; BRCA cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg16339924 chr4:17578868 LAP3 0.63 15.78 0.53 1.29e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7103648 0.567 rs12287076 chr11:47606865 G/C cg03711944 chr11:47377212 SPI1 0.35 8.65 0.32 4.18e-17 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg26647111 chr11:31128758 NA -0.42 -9.44 -0.35 6.61e-20 Red blood cell count; BRCA cis rs8141529 0.956 rs132539 chr22:29304253 C/T cg02153584 chr22:29168773 CCDC117 0.51 10.38 0.38 1.96e-23 Lymphocyte counts; BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg25036284 chr2:26402008 FAM59B -0.63 -10.53 -0.38 4.91e-24 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.59e-24 Motion sickness; BRCA cis rs2243480 1.000 rs402418 chr7:65509469 G/A cg18252515 chr7:66147081 NA -0.96 -13.74 -0.48 8.26e-38 Diabetic kidney disease; BRCA cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg08859206 chr1:53392774 SCP2 0.43 8.61 0.32 5.52e-17 Monocyte count; BRCA cis rs832540 0.656 rs832573 chr5:56159578 T/C cg24531977 chr5:56204891 C5orf35 -0.5 -10.43 -0.38 1.24e-23 Coronary artery disease; BRCA cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.73 -0.42 6.2e-29 Chronic sinus infection; BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18301423 chr5:131593218 PDLIM4 0.32 8.32 0.31 5.28e-16 Breast cancer; BRCA cis rs9467773 1.000 rs9467797 chr6:26568473 A/T cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.4e-57 Intelligence (multi-trait analysis); BRCA cis rs611744 0.647 rs4735053 chr8:109260776 A/G cg21045802 chr8:109455806 TTC35 0.35 7.89 0.3 1.32e-14 Dupuytren's disease; BRCA cis rs300703 0.542 rs300696 chr2:183330 G/A cg21211680 chr2:198530 NA -0.39 -8.15 -0.31 1.98e-15 Blood protein levels; BRCA cis rs898097 0.510 rs10445242 chr17:80891666 G/T cg15664640 chr17:80829946 TBCD 0.4 10.86 0.39 2.46e-25 Breast cancer; BRCA cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs919433 0.617 rs10460394 chr2:198548741 G/A cg00792783 chr2:198669748 PLCL1 -0.43 -9.49 -0.35 4.38e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7809950 0.678 rs3801966 chr7:106824580 G/A cg23024343 chr7:107201750 COG5 -0.45 -8.87 -0.33 7.51e-18 Coronary artery disease; BRCA cis rs758324 0.898 rs7725041 chr5:131188503 C/A cg06307176 chr5:131281290 NA 0.53 10.33 0.38 3.21e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7246967 0.611 rs16999598 chr19:22943125 A/G cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg13660082 chr14:53194042 PSMC6 -0.56 -8.16 -0.31 1.79e-15 Alzheimer's disease (late onset); BRCA cis rs58785573 0.570 rs1824652 chr4:38644597 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.52 11.5 0.41 5.79e-28 Lymphocyte percentage of white cells; BRCA cis rs1003719 0.788 rs1543748 chr21:38446581 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.19 0.49 6.61e-40 Eye color traits; BRCA cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.52 10.19 0.37 1.04e-22 Lung cancer in ever smokers; BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.82 -13.7 -0.48 1.17e-37 Platelet count; BRCA cis rs7582180 0.544 rs13026570 chr2:100939498 A/C cg14675211 chr2:100938903 LONRF2 0.5 11.1 0.4 2.58e-26 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg07606381 chr6:8435919 SLC35B3 -0.58 -12.54 -0.44 2.13e-32 Motion sickness; BRCA cis rs6743226 0.934 rs4234100 chr2:242265273 A/G cg10021735 chr2:242295487 FARP2 -0.35 -9.59 -0.35 1.9e-20 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs7945718 1.000 rs7945718 chr11:12748819 A/G cg25843174 chr11:12811716 TEAD1 0.23 8.52 0.32 1.19e-16 Educational attainment (years of education); BRCA cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg09184832 chr6:79620586 NA -0.54 -12.1 -0.43 1.77e-30 Intelligence (multi-trait analysis); BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg18446336 chr7:2847575 GNA12 -0.37 -7.96 -0.3 7.73e-15 Height; BRCA cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.36 -0.38 2.35e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.54 0.57 1.68e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.791 rs4896820 chr6:145894957 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.22 0.56 7.25e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs9462846 0.919 rs9462851 chr6:42890602 A/G cg02353165 chr6:42928485 GNMT 0.5 9.64 0.36 1.3e-20 Blood protein levels; BRCA cis rs10924970 0.687 rs28593631 chr1:235354572 A/T cg26050004 chr1:235667680 B3GALNT2 0.35 8.66 0.32 3.81e-17 Asthma; BRCA cis rs244731 0.959 rs918459 chr5:176669030 C/T cg06060754 chr5:176797920 RGS14 -0.66 -10.53 -0.38 5.03e-24 Urate levels in lean individuals; BRCA cis rs17253792 0.822 rs10483643 chr14:56089931 G/C cg01858014 chr14:56050164 KTN1 -0.75 -10.3 -0.38 4.01e-23 Putamen volume; BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -11.77 -0.42 4.46e-29 Tonsillectomy; BRCA cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg06115741 chr20:33292138 TP53INP2 0.51 11.47 0.41 7.93e-28 Coronary artery disease; BRCA cis rs11098499 0.954 rs10014845 chr4:120301077 T/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs12348691 0.503 rs7023267 chr9:100603935 G/A cg13688889 chr9:100608707 NA -0.45 -9.29 -0.34 2.36e-19 Alopecia areata; BRCA cis rs2882667 0.659 rs11750067 chr5:138256278 C/T cg04439458 chr5:138467593 SIL1 -0.35 -8.54 -0.32 9.46e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg04546413 chr19:29218101 NA 0.64 12.33 0.44 1.75e-31 Methadone dose in opioid dependence; BRCA cis rs7829975 0.711 rs4841051 chr8:8685646 C/T cg06636001 chr8:8085503 FLJ10661 -0.58 -13.69 -0.48 1.4e-37 Mood instability; BRCA trans rs1973993 0.691 rs2985636 chr1:96889884 T/A cg10631902 chr5:14652156 NA 0.57 19.7 0.61 7.41e-68 Weight; BRCA cis rs6586163 0.527 rs12775501 chr10:90750909 C/T cg03111039 chr10:90751583 FAS;ACTA2 0.56 12.86 0.45 7.73e-34 Chronic lymphocytic leukemia; BRCA cis rs6743226 0.748 rs12620606 chr2:242154015 A/G cg10021735 chr2:242295487 FARP2 0.32 8.6 0.32 6.06e-17 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.37 7.91 0.3 1.11e-14 Osteoporosis; BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.69 14.08 0.49 2.18e-39 Lymphocyte counts; BRCA cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg24130564 chr14:104152367 KLC1 0.36 8.04 0.3 4.49e-15 Intelligence (multi-trait analysis); BRCA cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg18016565 chr1:150552671 MCL1 -0.38 -8.77 -0.33 1.57e-17 Tonsillectomy; BRCA cis rs965469 0.779 rs6037534 chr20:3269832 G/A cg25506879 chr20:3388711 C20orf194 -0.44 -8.81 -0.33 1.17e-17 IFN-related cytopenia; BRCA cis rs911119 0.955 rs6048933 chr20:23595637 T/G cg16589663 chr20:23618590 CST3 0.43 7.95 0.3 8.67e-15 Chronic kidney disease; BRCA cis rs6088580 0.634 rs1205345 chr20:32914699 A/G cg08999081 chr20:33150536 PIGU -0.45 -12.23 -0.44 4.51e-31 Glomerular filtration rate (creatinine); BRCA cis rs941873 0.900 rs4979861 chr10:81131595 A/G cg08514558 chr10:81106712 PPIF 0.39 8.85 0.33 8.34e-18 Height; BRCA cis rs495337 1.000 rs4810997 chr20:48579348 G/T cg17835207 chr20:48524531 SPATA2 -0.62 -14.44 -0.5 4.02e-41 Psoriasis; BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18765753 chr7:1198926 ZFAND2A -0.56 -14.93 -0.51 1.85e-43 Longevity;Endometriosis; BRCA cis rs17376456 0.825 rs1470150 chr5:93138654 C/T cg25358565 chr5:93447407 FAM172A -1.0 -16.29 -0.54 3.91e-50 Diabetic retinopathy; BRCA cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.82e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs74181299 0.750 rs58342673 chr2:65347584 T/C cg05010058 chr2:65284262 CEP68 -0.3 -8.36 -0.31 3.9e-16 Pulse pressure; BRCA cis rs4664304 0.620 rs11895141 chr2:160716449 T/A cg01092293 chr2:160761427 LY75 0.36 8.51 0.32 1.24e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg04234412 chr22:24373322 LOC391322 0.69 17.79 0.58 7.87e-58 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.14 0.34 8.5e-19 Tonsillectomy; BRCA cis rs7917772 0.629 rs1475646 chr10:104522564 G/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.6 -0.39 2.74e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg27286337 chr10:134555280 INPP5A 0.79 12.95 0.46 3.09e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4919694 0.536 rs12414777 chr10:104697781 C/T cg04362960 chr10:104952993 NT5C2 0.57 11.46 0.41 8.85e-28 Arsenic metabolism; BRCA cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg14440974 chr22:39074834 NA -0.38 -9.0 -0.34 2.64e-18 Menopause (age at onset); BRCA cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -13.69 -0.48 1.39e-37 Hemoglobin concentration; BRCA cis rs2346177 0.519 rs1597040 chr2:46673903 C/T cg02822958 chr2:46747628 ATP6V1E2 0.55 10.69 0.39 1.21e-24 HDL cholesterol; BRCA cis rs867371 1.000 rs8041868 chr15:82472326 C/T cg00614314 chr15:82944287 LOC80154 0.44 9.3 0.35 2.19e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg20607798 chr8:58055168 NA 0.55 8.55 0.32 9.05e-17 Developmental language disorder (linguistic errors); BRCA cis rs3008870 1.000 rs2755245 chr1:67487964 C/G cg08660285 chr1:67390436 MIER1;WDR78 0.96 20.91 0.64 2.36e-74 Lymphocyte percentage of white cells; BRCA cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg07493874 chr5:1342172 CLPTM1L -0.51 -14.88 -0.51 3.07e-43 Lung cancer; BRCA cis rs7011049 1.000 rs72643599 chr8:53854434 A/G cg26025543 chr8:53854495 NA 0.55 9.49 0.35 4.66e-20 Systolic blood pressure; BRCA cis rs911555 0.755 rs8010247 chr14:103933556 A/G cg12935359 chr14:103987150 CKB 0.64 14.95 0.51 1.57e-43 Intelligence (multi-trait analysis); BRCA cis rs12971120 0.891 rs11151961 chr18:72177340 C/T cg26446133 chr18:72167187 CNDP2 -0.74 -12.9 -0.45 5.07e-34 Refractive error; BRCA cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.98e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg03433033 chr1:76189801 ACADM 0.76 17.01 0.56 8.25e-54 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg01191920 chr7:158217561 PTPRN2 0.36 8.54 0.32 1.02e-16 Obesity-related traits; BRCA cis rs7301826 0.651 rs10734979 chr12:131288954 T/C cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 2.86e-37 Plasma plasminogen activator levels; BRCA cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg03684893 chr10:554711 DIP2C 0.36 8.04 0.3 4.49e-15 Psychosis in Alzheimer's disease; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg18402987 chr7:1209562 NA 0.43 8.5 0.32 1.39e-16 Longevity;Endometriosis; BRCA cis rs1997103 0.911 rs17777 chr7:55380765 T/C cg17469321 chr7:55412551 NA 0.52 9.89 0.36 1.49e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg04455712 chr21:45112962 RRP1B 0.39 10.6 0.39 2.59e-24 Mean corpuscular volume; BRCA cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg04450456 chr4:17643702 FAM184B 0.37 11.06 0.4 3.78e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9287719 0.614 rs10929679 chr2:10723108 C/T cg00105475 chr2:10696890 NA 0.41 9.12 0.34 9.77e-19 Prostate cancer; BRCA trans rs7615952 0.515 rs4267608 chr3:125680500 C/T cg07211511 chr3:129823064 LOC729375 -0.57 -10.27 -0.38 5.06e-23 Blood pressure (smoking interaction); BRCA cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg24399712 chr22:39784796 NA -0.58 -12.43 -0.44 6.41e-32 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.807 rs9976441 chr21:45046591 G/A cg01579765 chr21:45077557 HSF2BP -0.39 -10.48 -0.38 7.97e-24 Mean corpuscular volume; BRCA cis rs11690935 0.921 rs10200608 chr2:172597929 G/A cg13550731 chr2:172543902 DYNC1I2 -0.93 -30.93 -0.77 4.04e-129 Schizophrenia; BRCA cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg14664628 chr15:75095509 CSK -0.94 -27.33 -0.73 1.67e-109 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs3617 0.625 rs7652667 chr3:52866535 C/A cg11645453 chr3:52864694 ITIH4 -0.38 -10.07 -0.37 3.01e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs6973256 0.901 rs2991231 chr7:133321915 T/C cg07491979 chr7:133331646 EXOC4 -0.38 -8.57 -0.32 7.97e-17 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.943 rs13345116 chr19:37847098 A/T cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs17685 0.712 rs869805 chr7:75688596 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.94 -0.33 4.08e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2882667 0.658 rs288003 chr5:138231955 T/G cg04439458 chr5:138467593 SIL1 -0.34 -8.4 -0.32 2.97e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6763687 0.828 rs6773362 chr3:171779873 T/G cg16233210 chr3:171778391 FNDC3B 0.38 8.33 0.31 4.78e-16 Red cell distribution width; BRCA cis rs9549260 0.753 rs61963266 chr13:41171036 G/A cg21288729 chr13:41239152 FOXO1 0.55 8.8 0.33 1.3e-17 Red blood cell count; BRCA cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg03517284 chr6:25882590 NA -0.45 -9.45 -0.35 6.5e-20 Intelligence (multi-trait analysis); BRCA cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg17724175 chr1:150552817 MCL1 0.26 8.25 0.31 8.94e-16 Tonsillectomy; BRCA trans rs11098499 0.566 rs7664440 chr4:120578540 A/G cg25214090 chr10:38739885 LOC399744 0.51 10.62 0.39 2.34e-24 Corneal astigmatism; BRCA cis rs11105298 0.891 rs11105319 chr12:89927177 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.26 -0.34 3.05e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg11789530 chr4:8429930 ACOX3 0.69 18.07 0.58 2.75e-59 Response to antineoplastic agents; BRCA cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg19717773 chr7:2847554 GNA12 -0.43 -9.68 -0.36 8.72e-21 Height; BRCA cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg22903471 chr2:27725779 GCKR -0.37 -9.2 -0.34 5.07e-19 Total body bone mineral density; BRCA trans rs629535 0.735 rs525610 chr8:70074535 A/G cg21567404 chr3:27674614 NA 1.01 21.1 0.64 2.2100000000000001e-75 Dupuytren's disease; BRCA cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg17063962 chr7:91808500 NA 0.54 12.71 0.45 3.65e-33 Breast cancer; BRCA trans rs2840044 0.963 rs225247 chr17:33944590 T/A cg19694781 chr19:47549865 TMEM160 -0.45 -10.52 -0.38 5.73e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg01483505 chr11:975446 AP2A2 -0.3 -8.12 -0.31 2.43e-15 Alzheimer's disease (late onset); BRCA cis rs703842 1.000 rs6581155 chr12:58178162 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.54 11.3 0.41 3.91e-27 Multiple sclerosis; BRCA cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg24829409 chr8:58192753 C8orf71 -0.57 -11.87 -0.43 1.6e-29 Developmental language disorder (linguistic errors); BRCA cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg02733842 chr7:1102375 C7orf50 -0.71 -12.41 -0.44 8.08e-32 Bronchopulmonary dysplasia; BRCA cis rs17125944 0.505 rs75661138 chr14:53259262 G/A cg00686598 chr14:53173677 PSMC6 1.23 16.58 0.55 1.3e-51 Alzheimer's disease (late onset); BRCA cis rs4719841 0.651 rs7789194 chr7:25992510 T/C cg24254488 chr7:25991654 NA -0.26 -7.94 -0.3 9.05e-15 Triglyceride levels; BRCA cis rs7809950 1.000 rs10251808 chr7:107120453 G/A cg23024343 chr7:107201750 COG5 -0.43 -9.95 -0.37 8.6e-22 Coronary artery disease; BRCA cis rs2204008 0.744 rs11514073 chr12:38399553 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.0 0.37 5.84e-22 Bladder cancer; BRCA cis rs17253792 0.822 rs10142497 chr14:56047948 C/T cg01858014 chr14:56050164 KTN1 0.78 11.54 0.42 3.89e-28 Putamen volume; BRCA cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg08603382 chr10:743973 NA 0.42 7.91 0.3 1.13e-14 Psychosis in Alzheimer's disease; BRCA cis rs858239 0.899 rs28635122 chr7:23310181 C/T cg23682824 chr7:23144976 KLHL7 0.36 9.1 0.34 1.12e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg15556689 chr8:8085844 FLJ10661 -0.39 -10.55 -0.39 4.31e-24 Mood instability; BRCA trans rs6582630 0.519 rs11181526 chr12:38360230 A/G cg06521331 chr12:34319734 NA -0.44 -8.35 -0.31 4.37e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg10932868 chr11:921992 NA -0.5 -12.92 -0.46 4.26e-34 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs1124253 chr4:98949682 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.9e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2455601 0.882 rs11042105 chr11:8894510 G/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -8.25 -0.31 8.83e-16 Schizophrenia; BRCA cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg19847866 chr10:1019161 NA -0.51 -10.06 -0.37 3.33e-22 Response to angiotensin II receptor blocker therapy; BRCA trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg13010199 chr12:38710504 ALG10B -0.48 -9.3 -0.35 2.11e-19 Morning vs. evening chronotype; BRCA cis rs2479724 0.811 rs6905726 chr6:41750812 T/C cg17623882 chr6:41773611 USP49 0.33 8.85 0.33 8.72e-18 Menarche (age at onset); BRCA cis rs10496034 1.000 rs76438263 chr2:55160965 G/A cg16098955 chr2:55172992 EML6 0.53 9.73 0.36 6.01e-21 Refractive astigmatism; BRCA cis rs875971 0.830 rs587360 chr7:65522698 C/A cg11764359 chr7:65958608 NA 0.75 17.42 0.57 7.03e-56 Aortic root size; BRCA cis rs4268898 0.760 rs4665675 chr2:24468132 C/T cg06627628 chr2:24431161 ITSN2 -0.4 -8.57 -0.32 8.06e-17 Asthma; BRCA cis rs9309473 1.000 rs13384952 chr2:73723959 C/T cg20560298 chr2:73613845 ALMS1 0.45 9.42 0.35 8.16e-20 Metabolite levels; BRCA cis rs4499344 0.633 rs259229 chr19:33134425 A/G cg22980127 chr19:33182716 NUDT19 0.45 9.16 0.34 6.85e-19 Mean platelet volume; BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -10.15 -0.37 1.53e-22 Alzheimer's disease; BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg22764044 chr5:178986830 RUFY1 0.4 9.6 0.36 1.72e-20 Lung cancer; BRCA cis rs10174077 0.874 rs4664490 chr2:152471923 C/G cg06191203 chr2:152266755 RIF1 0.34 9.93 0.37 1.08e-21 Squamous cell lung carcinoma; BRCA cis rs9325144 0.560 rs7304568 chr12:38632408 G/A cg13010199 chr12:38710504 ALG10B -0.36 -8.47 -0.32 1.68e-16 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs915351 chr6:8442793 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs7666738 0.830 rs1426672 chr4:98923984 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs870825 0.587 rs58332461 chr4:185639742 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA cis rs7666738 0.830 rs969049 chr4:98988857 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.56 0.39 3.97e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs701145 0.585 rs12493885 chr3:153839866 G/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg24642844 chr7:1081250 C7orf50 -0.77 -14.19 -0.49 6.19e-40 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8180040 0.966 rs11716763 chr3:47518266 C/T cg16586182 chr3:47516702 SCAP 0.65 15.13 0.51 1.95e-44 Colorectal cancer; BRCA cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs501916 0.605 rs2118917 chr15:48078992 C/T cg16110827 chr15:48056943 SEMA6D -0.4 -8.6 -0.32 6.13e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs10431058 1.000 rs10431058 chr11:107481518 A/G cg18204760 chr11:107461044 ELMOD1;LOC643923 -0.42 -9.39 -0.35 1.04e-19 Common traits (Other); BRCA cis rs9790314 0.639 rs6769642 chr3:160763469 C/A cg03342759 chr3:160939853 NMD3 -0.5 -9.48 -0.35 4.95e-20 Morning vs. evening chronotype; BRCA cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.52e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg24562669 chr7:97807699 LMTK2 0.5 12.51 0.44 2.8e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs17253792 0.822 rs12323476 chr14:56172722 C/T cg01858014 chr14:56050164 KTN1 0.53 8.72 0.33 2.38e-17 Putamen volume; BRCA cis rs9733 0.596 rs1336898 chr1:150665050 G/A cg18016565 chr1:150552671 MCL1 0.34 8.12 0.31 2.43e-15 Tonsillectomy; BRCA cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg05313129 chr8:58192883 C8orf71 -0.45 -9.71 -0.36 7.17e-21 Developmental language disorder (linguistic errors); BRCA cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg18252515 chr7:66147081 NA -0.56 -11.32 -0.41 3.29e-27 Corneal structure; BRCA cis rs7633857 0.536 rs1447609 chr3:160696311 A/G cg03342759 chr3:160939853 NMD3 -0.45 -9.34 -0.35 1.55e-19 Educational attainment (years of education); BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs7208859 0.623 rs11658022 chr17:29085359 A/T cg13385521 chr17:29058706 SUZ12P 0.74 10.21 0.37 9.16e-23 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs9660992 0.710 rs1172111 chr1:205232980 C/T cg00857998 chr1:205179979 DSTYK 0.41 8.19 0.31 1.42e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg11752832 chr7:134001865 SLC35B4 0.54 13.85 0.48 2.58e-38 Mean platelet volume; BRCA cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.24 0.38 6.86e-23 Heart rate; BRCA cis rs919433 0.680 rs1563340 chr2:198414713 A/T cg00792783 chr2:198669748 PLCL1 0.38 8.48 0.32 1.55e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg12591125 chr7:1885375 MAD1L1 0.5 8.69 0.33 3.1e-17 Bipolar disorder; BRCA cis rs11945232 1.000 rs28372775 chr4:88343704 G/A cg23841344 chr4:88312519 HSD17B11 -0.49 -9.56 -0.35 2.43e-20 Intelligence (multi-trait analysis); BRCA cis rs6580649 0.843 rs3803184 chr12:48398002 G/C cg05342945 chr12:48394962 COL2A1 -0.47 -9.55 -0.35 2.64e-20 Lung cancer; BRCA cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg02820040 chr2:241836501 C2orf54 -0.48 -8.68 -0.32 3.33e-17 Urinary metabolites; BRCA cis rs2070488 0.775 rs7649984 chr3:38570221 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.56 -14.06 -0.49 2.53e-39 Electrocardiographic conduction measures; BRCA cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg06115741 chr20:33292138 TP53INP2 0.49 11.17 0.4 1.43e-26 Coronary artery disease; BRCA cis rs11098499 0.863 rs3775844 chr4:120428033 G/A cg09307838 chr4:120376055 NA 0.7 14.3 0.49 1.96e-40 Corneal astigmatism; BRCA cis rs11051970 0.636 rs1045751 chr12:32569496 T/C cg24626660 chr12:32551988 NA 0.31 8.97 0.33 3.16e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg06640241 chr16:89574553 SPG7 0.75 17.65 0.57 4.11e-57 Multiple myeloma (IgH translocation); BRCA cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.44 -9.6 -0.36 1.77e-20 IgG glycosylation; BRCA trans rs3733585 0.578 rs6837224 chr4:9955255 G/T cg26043149 chr18:55253948 FECH -0.37 -8.3 -0.31 6.41e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg01939980 chr4:1354348 KIAA1530 0.38 10.6 0.39 2.79e-24 Longevity; BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -14.0 -0.48 4.93e-39 Platelet count; BRCA cis rs921968 0.541 rs490483 chr2:219429052 A/T cg10223061 chr2:219282414 VIL1 -0.27 -8.01 -0.3 5.33e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs4713675 0.584 rs7739505 chr6:33670370 G/A cg14003231 chr6:33640908 ITPR3 0.33 8.11 0.31 2.53e-15 Plateletcrit; BRCA cis rs782590 0.818 rs2627782 chr2:55825352 A/G cg18811423 chr2:55921094 PNPT1 0.69 21.1 0.64 2.14e-75 Metabolic syndrome; BRCA cis rs10504073 0.647 rs4873312 chr8:49991145 A/G cg00325661 chr8:49890786 NA 0.44 12.39 0.44 9.81e-32 Blood metabolite ratios; BRCA cis rs1883415 0.534 rs760906 chr6:24479845 C/T cg20631270 chr6:24437470 GPLD1 -0.39 -8.04 -0.3 4.52e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.5 -0.38 6.41e-24 Menarche (age at onset); BRCA cis rs10045504 0.502 rs72746031 chr5:38743161 G/A cg15396434 chr5:38725168 NA -0.57 -10.76 -0.39 6.43e-25 Night sleep phenotypes; BRCA cis rs2011503 0.943 rs4239639 chr19:19435876 G/A cg15839431 chr19:19639596 YJEFN3 0.41 9.0 0.34 2.54e-18 Bipolar disorder; BRCA cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA cis rs11105298 0.891 rs10858890 chr12:89907166 A/G cg00757033 chr12:89920650 WDR51B 0.52 10.54 0.38 4.66e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7714584 1.000 rs11167515 chr5:150239471 G/T cg22134413 chr5:150180641 NA 0.69 10.58 0.39 3.26e-24 Crohn's disease; BRCA cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg07828340 chr4:882639 GAK -1.04 -14.73 -0.5 1.68e-42 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs67265404 chr4:120359270 C/T cg25214090 chr10:38739885 LOC399744 0.54 12.12 0.43 1.39e-30 Corneal astigmatism; BRCA trans rs4942242 1.000 rs9562501 chr13:44205683 C/T cg19169023 chr15:41853346 TYRO3 -0.48 -11.22 -0.41 8.89e-27 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg24562669 chr7:97807699 LMTK2 -0.45 -12.0 -0.43 4.77e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7246657 0.943 rs8109632 chr19:37931125 A/T cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA cis rs965469 1.000 rs6051702 chr20:3251924 A/C cg25506879 chr20:3388711 C20orf194 -0.56 -10.92 -0.4 1.46e-25 IFN-related cytopenia; BRCA cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs7131987 0.650 rs11050208 chr12:29510369 T/G cg09582351 chr12:29534625 ERGIC2 -0.49 -10.26 -0.38 5.53e-23 QT interval; BRCA cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 8.17e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs965469 1.000 rs2281494 chr20:3235494 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -10.28 -0.38 4.89e-23 IFN-related cytopenia; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg15112475 chr7:1198522 ZFAND2A -0.54 -11.95 -0.43 7.32e-30 Longevity;Endometriosis; BRCA cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.23 0.74 1.93e-114 Chronic sinus infection; BRCA cis rs2294693 0.947 rs742492 chr6:40996381 G/A cg14418226 chr6:40996092 UNC5CL 0.45 8.24 0.31 1.01e-15 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg05283184 chr6:79620031 NA -0.43 -10.99 -0.4 7.52e-26 Intelligence (multi-trait analysis); BRCA cis rs10242455 0.702 rs45461000 chr7:99052710 A/G cg18809830 chr7:99032528 PTCD1 -0.64 -9.09 -0.34 1.18e-18 Blood metabolite levels; BRCA cis rs2882667 0.858 rs11957633 chr5:138364394 T/C cg04439458 chr5:138467593 SIL1 -0.42 -10.63 -0.39 2.11e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg13902645 chr11:5959945 NA -0.55 -12.76 -0.45 2.19e-33 DNA methylation (variation); BRCA cis rs2625529 0.824 rs1074330 chr15:72250741 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.46 -0.57 4.01e-56 Red blood cell count; BRCA cis rs13064411 0.518 rs1552433 chr3:113225730 C/A cg18753928 chr3:113234510 CCDC52 -0.4 -9.05 -0.34 1.77e-18 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs708547 0.836 rs1277287 chr4:57853147 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 13.56 0.47 5.28e-37 Response to bleomycin (chromatid breaks); BRCA cis rs2070488 0.965 rs2366119 chr3:38484453 C/T cg24069376 chr3:38537580 EXOG 0.43 12.16 0.43 9.35e-31 Electrocardiographic conduction measures; BRCA cis rs617791 0.669 rs4994056 chr11:65750997 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 10.02 0.37 4.7e-22 Breast cancer; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg16145915 chr7:1198662 ZFAND2A -0.47 -10.76 -0.39 6.44e-25 Longevity;Endometriosis; BRCA cis rs11112613 0.713 rs58066965 chr12:105952505 C/G cg03607813 chr12:105948248 NA 0.55 10.43 0.38 1.25e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg11271282 chr2:238384023 NA -0.44 -8.09 -0.3 2.99e-15 Prostate cancer; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg15787769 chr11:842744 TSPAN4;POLR2L -0.56 -13.42 -0.47 2.26e-36 Mean platelet volume; BRCA cis rs2882667 0.824 rs13189485 chr5:138475401 C/T cg04439458 chr5:138467593 SIL1 -0.44 -11.09 -0.4 2.93e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs17270561 0.609 rs9379778 chr6:25687579 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.87 0.33 7.32e-18 Iron status biomarkers; BRCA cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg26818010 chr10:134567672 INPP5A -0.78 -15.71 -0.53 2.93e-47 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2964802 0.505 rs6897847 chr5:10831632 T/C cg14521931 chr5:10832172 NA -0.58 -13.23 -0.46 1.79e-35 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg27535305 chr1:53392650 SCP2 0.32 7.89 0.3 1.28e-14 Monocyte count; BRCA cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg10802521 chr3:52805072 NEK4 -0.32 -8.25 -0.31 9.02e-16 Bipolar disorder; BRCA cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg11764359 chr7:65958608 NA -0.76 -16.73 -0.55 2.33e-52 Aortic root size; BRCA cis rs9487051 0.834 rs6919423 chr6:109558471 C/T cg21918786 chr6:109611834 NA -0.33 -8.52 -0.32 1.12e-16 Reticulocyte fraction of red cells; BRCA cis rs41005 1.000 rs12692349 chr2:8114312 G/A cg03155496 chr2:8117019 LOC339788 -0.56 -15.07 -0.51 3.76e-44 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg26408565 chr15:76604113 ETFA 0.52 11.91 0.43 1.08e-29 Blood metabolite levels; BRCA cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg20790798 chr5:1857306 NA -0.38 -8.96 -0.33 3.51e-18 Cardiovascular disease risk factors; BRCA cis rs9486719 1.000 rs2472887 chr6:96865437 A/G cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA cis rs12579753 1.000 rs10862373 chr12:82250657 A/G cg07988820 chr12:82153109 PPFIA2 -0.52 -8.7 -0.33 2.74e-17 Resting heart rate; BRCA cis rs7520050 0.931 rs6686134 chr1:46378268 A/G cg24296786 chr1:45957014 TESK2 0.43 9.78 0.36 3.77e-21 Red blood cell count;Reticulocyte count; BRCA cis rs877529 0.932 rs139398 chr22:39544970 C/G cg12193277 chr22:39547181 CBX7 0.48 12.96 0.46 2.87e-34 Multiple myeloma; BRCA cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg06115741 chr20:33292138 TP53INP2 0.39 8.58 0.32 7.19e-17 Glomerular filtration rate (creatinine); BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.39 -0.41 1.75e-27 Gut microbiome composition (summer); BRCA cis rs2625529 0.652 rs7497104 chr15:72154000 C/T cg16672083 chr15:72433130 SENP8 -0.69 -16.53 -0.55 2.25e-51 Red blood cell count; BRCA cis rs9457247 0.534 rs9366078 chr6:167399512 A/G cg23791538 chr6:167370224 RNASET2 0.5 12.63 0.45 8.12e-33 Crohn's disease; BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg13047869 chr3:10149882 C3orf24 0.51 11.08 0.4 3.1e-26 Alzheimer's disease; BRCA cis rs4812048 0.901 rs151355 chr20:57607645 G/C cg14073986 chr20:57617431 SLMO2 0.45 8.38 0.31 3.38e-16 Mean platelet volume; BRCA cis rs6867032 1.000 rs4246753 chr5:2014721 G/A cg26168224 chr5:2018326 NA 0.64 17.92 0.58 1.81e-58 Gut microbiome composition (winter); BRCA cis rs912057 0.797 rs1294430 chr6:6744698 A/G cg06612196 chr6:6737390 NA 0.4 8.86 0.33 7.98e-18 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs1215050 0.791 rs649866 chr4:98738826 T/C cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.87e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2880765 0.835 rs4843062 chr15:86040137 A/G cg10818794 chr15:86012489 AKAP13 -0.29 -8.1 -0.31 2.84e-15 Coronary artery disease; BRCA cis rs8103278 1.000 rs11671524 chr19:46327166 G/A cg20908204 chr19:46285434 DMPK -0.27 -8.05 -0.3 4.19e-15 Coronary artery disease; BRCA cis rs6815814 0.851 rs9715769 chr4:38774489 A/C cg06935464 chr4:38784597 TLR10 0.48 8.15 0.31 1.96e-15 Breast cancer; BRCA cis rs79976124 0.800 rs12194767 chr6:66639599 A/G cg07460842 chr6:66804631 NA 0.57 9.87 0.36 1.74e-21 Type 2 diabetes; BRCA cis rs9393692 0.676 rs806977 chr6:26189615 A/G cg00631329 chr6:26305371 NA -0.41 -11.31 -0.41 3.51e-27 Educational attainment; BRCA trans rs12458462 0.892 rs2242174 chr18:77458037 T/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -8.75 -0.33 1.92e-17 Monocyte count; BRCA cis rs17376456 0.877 rs10476526 chr5:93461916 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.14 0.31 2.1e-15 Diabetic retinopathy; BRCA cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA cis rs4363385 0.747 rs6671414 chr1:152974119 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -9.3 -0.35 2.18e-19 Inflammatory skin disease; BRCA cis rs3767633 0.925 rs10733044 chr1:161903534 A/G cg09175582 chr1:161736000 ATF6 -0.52 -8.34 -0.31 4.41e-16 IgG glycosylation; BRCA cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.47 -8.98 -0.33 2.98e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6598955 0.543 rs3795687 chr1:26560745 G/A cg04990556 chr1:26633338 UBXN11 0.68 11.87 0.42 1.7e-29 Obesity-related traits; BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -1.1 -20.09 -0.62 5.61e-70 Platelet count; BRCA cis rs9463078 0.838 rs9395066 chr6:45095163 A/C cg25276700 chr6:44698697 NA -0.36 -8.2 -0.31 1.36e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7246657 0.943 rs1015848 chr19:37945274 A/C cg23950597 chr19:37808831 NA -0.74 -13.09 -0.46 7.77e-35 Coronary artery calcification; BRCA trans rs6089829 0.816 rs6062397 chr20:61668268 A/G cg23505145 chr19:12996616 KLF1 0.54 12.31 0.44 2.07e-31 Prostate cancer (SNP x SNP interaction); BRCA trans rs6951245 0.638 rs4720486 chr7:1146764 G/A cg13565492 chr6:43139072 SRF -0.9 -16.34 -0.54 2.14e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2243480 1.000 rs1701750 chr7:65467145 T/C cg18252515 chr7:66147081 NA -0.86 -12.34 -0.44 1.53e-31 Diabetic kidney disease; BRCA cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg19077165 chr18:44547161 KATNAL2 -0.56 -12.2 -0.43 6.06e-31 Personality dimensions; BRCA cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg10802521 chr3:52805072 NEK4 -0.33 -9.1 -0.34 1.13e-18 Bipolar disorder; BRCA cis rs10876993 0.855 rs1689601 chr12:58049557 G/A cg00677455 chr12:58241039 CTDSP2 -0.35 -7.88 -0.3 1.39e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs3820928 0.904 rs6735069 chr2:227893660 A/G cg11843606 chr2:227700838 RHBDD1 -0.36 -7.82 -0.3 2.15e-14 Pulmonary function; BRCA cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.73e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg27129171 chr3:47204927 SETD2 0.72 17.71 0.57 2.19e-57 Colorectal cancer; BRCA trans rs783540 0.967 rs2567635 chr15:83262181 T/G cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.16 -0.31 1.83e-15 Schizophrenia; BRCA cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg06046430 chr4:77819534 ANKRD56 0.6 13.28 0.47 1.01e-35 Emphysema distribution in smoking; BRCA cis rs3739998 0.647 rs7920686 chr10:30317838 A/G cg00730780 chr10:30316187 KIAA1462 0.54 11.53 0.41 4.5e-28 Coronary heart disease; BRCA cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -10.87 -0.4 2.25e-25 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs13191362 0.938 rs35211042 chr6:162998703 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.45 8.02 0.3 5e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1355223 0.583 rs2941044 chr11:34867444 A/C cg11058730 chr11:34937778 PDHX;APIP 0.7 16.4 0.54 9.98e-51 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7640424 0.620 rs7637244 chr3:107815763 T/A cg09227934 chr3:107805635 CD47 -0.43 -8.19 -0.31 1.44e-15 Body mass index; BRCA cis rs7727544 0.836 rs10463892 chr5:131598705 T/C cg12564285 chr5:131593104 PDLIM4 0.31 8.2 0.31 1.34e-15 Blood metabolite levels; BRCA cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg05025164 chr4:1340916 KIAA1530 0.77 15.84 0.53 6.32e-48 Longevity; BRCA cis rs6087990 0.806 rs6088008 chr20:31382860 A/G cg13636640 chr20:31349939 DNMT3B 0.61 19.0 0.6 3.93e-64 Ulcerative colitis; BRCA cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg02389323 chr16:88786976 FAM38A 0.97 13.73 0.48 8.67e-38 Plateletcrit; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg20607798 chr8:58055168 NA 0.53 8.3 0.31 6.13e-16 Developmental language disorder (linguistic errors); BRCA cis rs1580019 1.000 rs1580019 chr7:32493169 A/T cg07520158 chr7:32535189 LSM5;AVL9 -0.41 -8.96 -0.33 3.61e-18 Cognitive ability; BRCA cis rs910316 0.763 rs175435 chr14:75612025 A/G cg23033748 chr14:75592666 NEK9 0.36 8.52 0.32 1.18e-16 Height; BRCA cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg15017067 chr4:17643749 FAM184B 0.32 9.99 0.37 5.99e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.71 -0.5 2.23e-42 Hemoglobin concentration; BRCA cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg19508488 chr2:152266495 RIF1 0.51 10.48 0.38 8.25e-24 Lung cancer; BRCA cis rs7927592 0.913 rs12272917 chr11:68263370 T/C cg20283391 chr11:68216788 NA -0.48 -9.33 -0.35 1.74e-19 Total body bone mineral density; BRCA cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -11.08 -0.4 3.19e-26 Bipolar disorder and schizophrenia; BRCA cis rs34779708 0.931 rs34087268 chr10:35346724 T/G cg03585969 chr10:35415529 CREM 0.56 11.49 0.41 6.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.42 -9.89 -0.36 1.43e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7590368 0.961 rs2357815 chr2:10959769 C/T cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.02e-15 Educational attainment (years of education); BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 20.35 0.63 2.46e-71 Platelet count; BRCA cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg06784218 chr1:46089804 CCDC17 -0.52 -12.51 -0.44 2.7e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11098499 0.775 rs10021601 chr4:120282563 G/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.44 0.35 6.71e-20 Intelligence (multi-trait analysis); BRCA cis rs9660992 0.710 rs7367930 chr1:205235512 A/G cg00857998 chr1:205179979 DSTYK 0.45 8.42 0.32 2.42e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs765787 0.530 rs12323957 chr15:45490773 C/T cg24006582 chr15:45444508 DUOX1 0.6 11.65 0.42 1.42e-28 Uric acid levels; BRCA cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.56 0.35 2.56e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg03264133 chr6:25882463 NA -0.49 -11.01 -0.4 6.3e-26 Blood metabolite levels; BRCA cis rs7572733 0.534 rs700673 chr2:198692929 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.16 0.37 1.34e-22 Dermatomyositis; BRCA cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg08999081 chr20:33150536 PIGU 0.46 12.85 0.45 8.96e-34 Glomerular filtration rate (creatinine); BRCA cis rs17125944 0.505 rs17125746 chr14:53236079 C/T cg13660082 chr14:53194042 PSMC6 -0.57 -8.16 -0.31 1.8e-15 Alzheimer's disease (late onset); BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg25036284 chr2:26402008 FAM59B 0.96 15.93 0.53 2.36e-48 Gut microbiome composition (summer); BRCA cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg03060546 chr3:49711283 APEH -0.57 -7.85 -0.3 1.79e-14 Cognitive function; BRCA cis rs9811920 0.569 rs793445 chr3:99576644 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.15 0.31 1.99e-15 Axial length; BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg11766577 chr21:47581405 C21orf56 -0.45 -10.15 -0.37 1.53e-22 Testicular germ cell tumor; BRCA cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.66 -0.57 3.68e-57 Chronic sinus infection; BRCA cis rs61931739 0.500 rs10844734 chr12:34043083 G/A cg06521331 chr12:34319734 NA -0.63 -12.2 -0.43 6.34e-31 Morning vs. evening chronotype; BRCA trans rs9329221 0.537 rs2062331 chr8:9979992 C/T cg15556689 chr8:8085844 FLJ10661 -0.32 -8.68 -0.32 3.37e-17 Neuroticism; BRCA cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg11584989 chr19:19387371 SF4 0.62 12.66 0.45 6.47e-33 Bipolar disorder; BRCA cis rs7666738 0.830 rs13118945 chr4:98968586 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.64e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg18402987 chr7:1209562 NA -0.44 -8.41 -0.32 2.75e-16 Longevity;Endometriosis; BRCA cis rs11690935 0.632 rs6433323 chr2:172873060 A/G cg13550731 chr2:172543902 DYNC1I2 -0.54 -13.66 -0.48 1.86e-37 Schizophrenia; BRCA cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg26116260 chr4:7069785 GRPEL1 -0.84 -16.4 -0.54 1.08e-50 Monocyte percentage of white cells; BRCA cis rs1882538 0.503 rs13240997 chr7:133135373 C/A cg10665199 chr7:133106180 EXOC4 0.47 9.53 0.35 3.15e-20 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs61811427 chr1:152968419 C/T cg21543102 chr1:152974771 SPRR3 -0.3 -8.22 -0.31 1.16e-15 Inflammatory skin disease; BRCA cis rs208520 0.690 rs12197578 chr6:66725905 C/T cg07460842 chr6:66804631 NA 0.98 19.59 0.61 2.75e-67 Exhaled nitric oxide output; BRCA cis rs1538970 0.816 rs4633317 chr1:45985157 T/C cg05343316 chr1:45956843 TESK2 0.7 14.26 0.49 2.98e-40 Platelet count; BRCA cis rs11997175 0.766 rs56803376 chr8:33687676 T/C ch.8.33884649F chr8:33765107 NA 0.35 8.09 0.3 3.04e-15 Body mass index; BRCA cis rs1682361 1 rs1682361 chr3:136734014 G/C cg21827317 chr3:136751795 NA 0.61 15.04 0.51 5.4e-44 Schizophrenia; BRCA cis rs6840360 0.615 rs12647465 chr4:152607318 C/A cg22705602 chr4:152727874 NA -0.38 -10.35 -0.38 2.51e-23 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg06238570 chr21:40685208 BRWD1 -0.43 -8.6 -0.32 6.14e-17 Cognitive function; BRCA cis rs3849570 0.925 rs1464791 chr3:81893929 A/C cg07356753 chr3:81810745 GBE1 0.41 9.85 0.36 2.07e-21 Waist circumference;Body mass index; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg25703541 chr22:24373054 LOC391322 0.89 23.11 0.67 2.3e-86 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg24642844 chr7:1081250 C7orf50 -0.87 -15.93 -0.53 2.34e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13108904 0.875 rs1564509 chr4:1236562 C/G cg05665937 chr4:1216051 CTBP1 0.41 8.48 0.32 1.6e-16 Obesity-related traits; BRCA cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.6 0.32 6.11e-17 Personality dimensions; BRCA cis rs10046574 0.561 rs7781454 chr7:135205422 A/G cg27474649 chr7:135195673 CNOT4 0.61 10.32 0.38 3.39e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs3733585 0.673 rs4455410 chr4:9953297 C/T cg26043149 chr18:55253948 FECH 0.37 8.12 0.31 2.39e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7659604 0.840 rs6821305 chr4:122713863 A/C cg06713675 chr4:122721982 EXOSC9 -0.39 -9.69 -0.36 8.07e-21 Type 2 diabetes; BRCA cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg23018236 chr17:30244563 NA 0.46 7.86 0.3 1.66e-14 Hip circumference adjusted for BMI; BRCA cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg16414030 chr3:133502952 NA 0.44 10.41 0.38 1.52e-23 Iron status biomarkers; BRCA trans rs1493916 0.870 rs8097667 chr18:31387003 C/T cg15819921 chr19:927150 ARID3A -0.48 -9.12 -0.34 1e-18 Life satisfaction; BRCA cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06022373 chr22:39101656 GTPBP1 0.75 18.37 0.59 7.91e-61 Menopause (age at onset); BRCA cis rs17376456 1.000 rs9968749 chr5:93509559 A/G cg21475434 chr5:93447410 FAM172A 0.68 8.81 0.33 1.17e-17 Diabetic retinopathy; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg16812893 chr21:31813075 KRTAP15-1 0.4 9.74 0.36 5.28e-21 HDL cholesterol; BRCA cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg21535247 chr6:8435926 SLC35B3 0.39 8.84 0.33 9.45e-18 Motion sickness; BRCA cis rs7179456 0.547 rs6494036 chr15:59015961 A/T cg05156742 chr15:59063176 FAM63B 0.51 10.2 0.37 1.02e-22 Asperger disorder; BRCA cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24531977 chr5:56204891 C5orf35 -0.72 -16.07 -0.54 4.64e-49 Initial pursuit acceleration; BRCA cis rs10751667 0.666 rs7944815 chr11:959776 C/T cg06064525 chr11:970664 AP2A2 -0.49 -16.18 -0.54 1.25e-49 Alzheimer's disease (late onset); BRCA cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg17644776 chr2:200775616 C2orf69 0.43 8.92 0.33 4.78e-18 Osteoporosis; BRCA trans rs9858542 0.953 rs9821311 chr3:49543656 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.48 -0.35 4.76e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.75 0.33 1.9e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9309711 0.698 rs9750503 chr2:3491772 A/G cg10845886 chr2:3471009 TTC15 0.77 16.14 0.54 2.14e-49 Neurofibrillary tangles; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg00106254 chr7:1943704 MAD1L1 -0.45 -11.35 -0.41 2.54e-27 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg18132916 chr6:79620363 NA -0.5 -11.37 -0.41 2.03e-27 Intelligence (multi-trait analysis); BRCA cis rs636291 0.517 rs673254 chr1:10550352 C/T cg07384165 chr1:10488281 NA -0.4 -8.5 -0.32 1.32e-16 Prostate cancer; BRCA cis rs1707322 0.752 rs11211168 chr1:46163647 C/T cg03146154 chr1:46216737 IPP 0.52 11.58 0.42 2.72e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg18850127 chr7:39170497 POU6F2 0.47 10.24 0.38 6.63e-23 IgG glycosylation; BRCA cis rs7639513 0.767 rs7648488 chr3:12708946 T/C cg23032965 chr3:12705835 RAF1 0.7 15.4 0.52 1e-45 Itch intensity from mosquito bite; BRCA cis rs6815814 0.950 rs3924112 chr4:38795810 C/T cg02016764 chr4:38805732 TLR1 -0.64 -9.91 -0.37 1.23e-21 Breast cancer; BRCA cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg14004847 chr7:1930337 MAD1L1 -0.39 -8.22 -0.31 1.16e-15 Schizophrenia; BRCA cis rs7560272 0.538 rs17434655 chr2:73923089 C/T cg20560298 chr2:73613845 ALMS1 -0.34 -9.11 -0.34 1.06e-18 Schizophrenia; BRCA cis rs7847628 0.587 rs3793638 chr9:123582697 G/T cg03808351 chr9:123631620 PHF19 0.61 12.65 0.45 6.68e-33 Birth weight; BRCA cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.68 0.32 3.31e-17 Glomerular filtration rate (creatinine); BRCA trans rs3960554 0.808 rs78811105 chr7:75702795 G/A cg19862616 chr7:65841803 NCRNA00174 0.6 12.35 0.44 1.37e-31 Eotaxin levels; BRCA cis rs611744 0.647 rs2848620 chr8:109249551 G/T cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs7666738 0.830 rs28769113 chr4:98950371 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.77e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg17366294 chr4:99064904 C4orf37 0.42 9.76 0.36 4.44e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4481887 0.927 rs10127803 chr1:248476196 A/T cg00666640 chr1:248458726 OR2T12 0.3 8.45 0.32 2e-16 Common traits (Other); BRCA cis rs13082711 0.689 rs34946790 chr3:27345170 G/A cg02860705 chr3:27208620 NA 0.82 15.0 0.51 8.87e-44 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg17971929 chr21:40555470 PSMG1 -0.62 -14.61 -0.5 6.07e-42 Cognitive function; BRCA cis rs701145 0.938 rs789380 chr3:154081424 G/A cg17054900 chr3:154042577 DHX36 0.68 11.84 0.42 2.31e-29 Coronary artery disease; BRCA cis rs1707322 1.000 rs10890353 chr1:46298383 G/T cg03146154 chr1:46216737 IPP 0.46 10.34 0.38 2.89e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2070488 0.965 rs7372386 chr3:38484175 C/G cg24069376 chr3:38537580 EXOG 0.4 11.58 0.42 2.78e-28 Electrocardiographic conduction measures; BRCA trans rs60843830 1.000 rs7605824 chr2:280819 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.65 -14.24 -0.49 3.55e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1405069 0.809 rs1046279 chr6:36932571 C/T cg26433444 chr6:36932349 PI16 -0.47 -12.38 -0.44 1.01e-31 Chemerin levels; BRCA cis rs7095944 0.554 rs11245344 chr10:126418782 C/T cg08799069 chr10:126477246 METTL10 -0.37 -8.72 -0.33 2.31e-17 Asthma; BRCA cis rs1595825 0.891 rs7584475 chr2:198577424 A/C cg19156104 chr2:198669113 PLCL1 -0.46 -8.34 -0.31 4.54e-16 Ulcerative colitis; BRCA trans rs1493916 0.655 rs4534926 chr18:31349072 G/C cg27147174 chr7:100797783 AP1S1 -0.56 -10.7 -0.39 1.07e-24 Life satisfaction; BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg25036284 chr2:26402008 FAM59B 0.75 10.47 0.38 8.46e-24 Gut microbiome composition (summer); BRCA cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg23711669 chr6:146136114 FBXO30 -0.72 -16.98 -0.56 1.25e-53 Lobe attachment (rater-scored or self-reported); BRCA trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA trans rs11098499 0.722 rs10006192 chr4:120263022 T/C cg25214090 chr10:38739885 LOC399744 0.42 9.67 0.36 9.88e-21 Corneal astigmatism; BRCA cis rs295137 0.836 rs1217429 chr2:201094151 G/T cg23649088 chr2:200775458 C2orf69 0.42 8.97 0.33 3.21e-18 Asthma (bronchodilator response); BRCA cis rs10992471 0.580 rs7030920 chr9:95122952 A/G cg14631576 chr9:95140430 CENPP -0.4 -9.69 -0.36 8.29e-21 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.2 0.56 8.9e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs9467773 1.000 rs6903973 chr6:26499942 C/A cg11502198 chr6:26597334 ABT1 0.48 9.55 0.35 2.78e-20 Intelligence (multi-trait analysis); BRCA cis rs1949733 0.675 rs2688219 chr4:8444631 T/C cg13073564 chr4:8508604 NA -0.39 -10.58 -0.39 3.34e-24 Response to antineoplastic agents; BRCA cis rs2248020 0.501 rs2263368 chr11:93264680 A/C cg15737290 chr11:93063684 CCDC67 0.35 8.2 0.31 1.31e-15 Insulin levels in response to oral glucose tolerance test (30 minutes); BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -11.8 -0.42 3.35e-29 Gut microbiome composition (summer); BRCA cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.2 -0.37 1.02e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs9951602 0.833 rs9953548 chr18:76640601 C/T cg02800362 chr5:177631904 HNRNPAB 0.73 12.5 0.44 3.24e-32 Obesity-related traits; BRCA cis rs7560272 0.501 rs11894953 chr2:73964631 A/G cg20560298 chr2:73613845 ALMS1 -0.33 -8.64 -0.32 4.47e-17 Schizophrenia; BRCA cis rs425277 1.000 rs262672 chr1:2080813 G/T cg00981070 chr1:2046702 PRKCZ 0.31 8.25 0.31 9.06e-16 Height; BRCA trans rs1005277 0.579 rs1780136 chr10:38501453 A/G cg17830980 chr10:43048298 ZNF37B -0.53 -12.81 -0.45 1.36e-33 Extrinsic epigenetic age acceleration; BRCA cis rs936229 0.768 rs936226 chr15:75069282 C/T cg10253484 chr15:75165896 SCAMP2 -0.53 -9.87 -0.36 1.73e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg08470875 chr2:26401718 FAM59B -0.51 -8.26 -0.31 8.29e-16 Gut microbiome composition (summer); BRCA cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg04267008 chr7:1944627 MAD1L1 0.52 11.47 0.41 7.72e-28 Bipolar disorder and schizophrenia; BRCA cis rs9399137 0.507 rs13064 chr6:135287533 A/G cg24558204 chr6:135376177 HBS1L 0.59 15.93 0.53 2.3e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs875971 1.000 rs6961717 chr7:65587537 C/T cg11764359 chr7:65958608 NA -0.79 -19.22 -0.61 2.44e-65 Aortic root size; BRCA cis rs690037 0.528 rs568833 chr3:16367836 C/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.38 -8.34 -0.31 4.42e-16 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); BRCA cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.35 0.31 4.2e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg08917208 chr2:24149416 ATAD2B 0.59 9.22 0.34 4.41e-19 Lymphocyte counts; BRCA cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg14196790 chr5:131705035 SLC22A5 -0.41 -10.1 -0.37 2.35e-22 Breast cancer;Mosquito bite size; BRCA cis rs858239 0.932 rs1624451 chr7:23262435 A/T cg23682824 chr7:23144976 KLHL7 -0.33 -8.44 -0.32 2.13e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 9.5 0.35 4.3e-20 Rheumatoid arthritis; BRCA cis rs1707322 1.000 rs1588663 chr1:46548825 G/A cg06784218 chr1:46089804 CCDC17 -0.44 -10.47 -0.38 8.95e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6964587 0.869 rs406 chr7:91546526 C/A cg17063962 chr7:91808500 NA -0.52 -12.14 -0.43 1.1e-30 Breast cancer; BRCA cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.66 0.36 1.09e-20 Parkinson's disease; BRCA cis rs16854884 0.632 rs35716467 chr3:143684993 C/A cg06585982 chr3:143692056 C3orf58 0.44 9.28 0.34 2.58e-19 Economic and political preferences (feminism/equality); BRCA cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg26395211 chr5:140044315 WDR55 0.37 8.52 0.32 1.16e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs896854 0.902 rs726816 chr8:95968413 T/G cg26343298 chr8:95960752 TP53INP1 0.28 7.93 0.3 1.01e-14 Type 2 diabetes; BRCA cis rs7631605 0.935 rs9861967 chr3:37158798 C/T cg15934958 chr3:37212084 LRRFIP2 0.41 9.52 0.35 3.64e-20 Cerebrospinal P-tau181p levels; BRCA cis rs9653442 0.675 rs961788 chr2:100641459 T/C cg22139774 chr2:100720529 AFF3 -0.29 -8.1 -0.31 2.86e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs2463822 1.000 rs1406384 chr11:62083530 A/G cg06239285 chr11:62104954 ASRGL1 -0.64 -11.19 -0.4 1.11e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs939658 0.805 rs8035606 chr15:79420245 C/T cg17916960 chr15:79447300 NA -0.47 -11.69 -0.42 9.96e-29 Refractive error; BRCA cis rs6920965 0.563 rs1544292 chr6:126175093 G/C cg05901451 chr6:126070800 HEY2 -0.36 -8.69 -0.33 2.94e-17 High light scatter reticulocyte count; BRCA cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg17330251 chr7:94953956 PON1 -0.42 -8.78 -0.33 1.54e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7085104 0.572 rs284860 chr10:104572963 T/C cg04362960 chr10:104952993 NT5C2 -0.33 -7.97 -0.3 7.46e-15 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs4268898 0.529 rs4426488 chr2:24372815 A/G cg26838691 chr2:24397539 C2orf84 0.4 8.16 0.31 1.75e-15 Asthma; BRCA cis rs1707322 0.752 rs4660313 chr1:46110841 A/G cg03146154 chr1:46216737 IPP -0.51 -11.37 -0.41 2.11e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs360798 0.512 rs17027429 chr2:63079983 C/T cg17519650 chr2:63277830 OTX1 0.37 8.25 0.31 8.86e-16 Coronary artery disease; BRCA cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg13010199 chr12:38710504 ALG10B 0.52 10.48 0.38 8.03e-24 Bladder cancer; BRCA cis rs6942756 1.000 rs68076553 chr7:128959632 A/G cg02491457 chr7:128862824 NA -0.71 -14.03 -0.49 3.56e-39 White matter hyperintensity burden; BRCA cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.33 -9.98 -0.37 6.82e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg19622623 chr12:86230825 RASSF9 -0.29 -8.15 -0.31 1.97e-15 Major depressive disorder; BRCA cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg18230493 chr5:56204884 C5orf35 -0.74 -14.92 -0.51 2.06e-43 Initial pursuit acceleration; BRCA cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg23205692 chr1:25664452 TMEM50A -0.37 -8.81 -0.33 1.17e-17 Plateletcrit;Mean corpuscular volume; BRCA cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06601766 chr17:61851465 DDX42;CCDC47 -0.59 -13.49 -0.47 1.12e-36 Height; BRCA cis rs832540 0.552 rs252924 chr5:56205643 A/G cg18230493 chr5:56204884 C5orf35 -0.44 -9.01 -0.34 2.32e-18 Coronary artery disease; BRCA cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs6080550 1.000 rs6080550 chr20:1759590 A/G cg03128590 chr20:1760507 NA 0.54 9.52 0.35 3.46e-20 Non-obstructive azoospermia; BRCA cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg11833968 chr6:79620685 NA -0.43 -9.6 -0.35 1.8e-20 Intelligence (multi-trait analysis); BRCA cis rs4803468 1.000 rs4674 chr19:41930396 A/G cg09537434 chr19:41945824 ATP5SL -1.0 -23.17 -0.68 1.08e-86 Height; BRCA trans rs3733585 0.638 rs6449155 chr4:9956547 T/G cg26043149 chr18:55253948 FECH -0.37 -8.29 -0.31 6.69e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9325144 0.647 rs4616077 chr12:39092364 T/C cg26384229 chr12:38710491 ALG10B -0.48 -11.21 -0.41 9.33e-27 Morning vs. evening chronotype; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.94 -0.33 4.29e-18 Total body bone mineral density; BRCA cis rs9354352 0.818 rs9453548 chr6:66691885 T/C cg07460842 chr6:66804631 NA -0.59 -12.76 -0.45 2.24e-33 Initial pursuit acceleration in psychotic disorders; BRCA cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg08885076 chr2:99613938 TSGA10 0.51 10.03 0.37 4.33e-22 Chronic sinus infection; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg03188948 chr7:1209495 NA 0.84 11.6 0.42 2.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs113835537 0.559 rs74933537 chr11:66274958 A/C cg24851651 chr11:66362959 CCS 0.44 8.32 0.31 5.13e-16 Airway imaging phenotypes; BRCA cis rs7085104 0.632 rs7096475 chr10:104609676 A/G cg04362960 chr10:104952993 NT5C2 0.4 9.71 0.36 7.17e-21 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs698833 0.828 rs4952710 chr2:44524575 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.1 0.37 2.34e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs826838 0.967 rs11183514 chr12:38760744 A/T cg13010199 chr12:38710504 ALG10B 0.56 12.33 0.44 1.71e-31 Heart rate; BRCA cis rs2387326 0.717 rs10829338 chr10:129943625 C/T cg16087940 chr10:129947807 NA -0.45 -7.94 -0.3 8.99e-15 Select biomarker traits; BRCA cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg22974920 chr21:40686053 BRWD1 -0.34 -7.87 -0.3 1.54e-14 Menarche (age at onset); BRCA cis rs6545883 0.895 rs4430924 chr2:61703856 A/G cg15711740 chr2:61764176 XPO1 -0.55 -13.22 -0.46 1.89e-35 Tuberculosis; BRCA cis rs965469 1.000 rs6051806 chr20:3350319 C/T cg25506879 chr20:3388711 C20orf194 -0.56 -10.79 -0.39 4.92e-25 IFN-related cytopenia; BRCA cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg01483505 chr11:975446 AP2A2 -0.31 -8.54 -0.32 9.66e-17 Alzheimer's disease (late onset); BRCA cis rs7729447 0.776 rs17442964 chr5:32693916 G/A cg16267343 chr5:32710456 NPR3 0.44 9.1 0.34 1.15e-18 Blood pressure; BRCA trans rs7824557 0.592 rs920044 chr8:11224313 C/T cg06636001 chr8:8085503 FLJ10661 0.42 8.52 0.32 1.14e-16 Retinal vascular caliber; BRCA cis rs977987 0.806 rs766521 chr16:75424154 A/G cg03315344 chr16:75512273 CHST6 -0.5 -11.96 -0.43 7.13e-30 Dupuytren's disease; BRCA cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg13073564 chr4:8508604 NA -0.39 -10.79 -0.39 4.87e-25 Response to antineoplastic agents; BRCA cis rs2204008 0.660 rs2320745 chr12:38239101 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.12 0.51 2.34e-44 Bladder cancer; BRCA cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg04511125 chr2:88470314 THNSL2 0.95 13.58 0.47 4.48e-37 Plasma clusterin levels; BRCA cis rs7447593 0.518 rs4074995 chr5:176797343 C/T cg16006841 chr5:176797999 RGS14 0.94 19.66 0.61 1.24e-67 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs7894051 1.000 rs11101721 chr10:135190358 C/G cg24905316 chr10:135186343 ECHS1 0.51 8.05 0.3 4.02e-15 Lifespan; BRCA cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg24812749 chr6:127587940 RNF146 0.82 18.9 0.6 1.35e-63 Breast cancer; BRCA cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg12386194 chr3:101231763 SENP7 0.46 9.79 0.36 3.64e-21 Colorectal cancer; BRCA cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg16586182 chr3:47516702 SCAP -0.55 -12.42 -0.44 7.15e-32 Colorectal cancer; BRCA cis rs6815814 0.898 rs5743562 chr4:38806096 T/C cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs6690583 0.697 rs2012369 chr1:85520845 T/C cg11262906 chr1:85462892 MCOLN2 -0.49 -9.3 -0.35 2.28e-19 Serum sulfate level; BRCA cis rs7666738 0.830 rs13124904 chr4:98856973 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs9308433 0.798 rs10157166 chr1:214484950 C/T cg06198575 chr1:214491504 SMYD2 0.43 10.06 0.37 3.34e-22 IgG glycosylation; BRCA trans rs2197308 0.610 rs10880837 chr12:37864924 C/T cg06521331 chr12:34319734 NA -0.51 -9.41 -0.35 9.14e-20 Morning vs. evening chronotype; BRCA cis rs9790314 0.875 rs336582 chr3:161082659 C/T cg03342759 chr3:160939853 NMD3 -0.55 -12.11 -0.43 1.58e-30 Morning vs. evening chronotype; BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg21782813 chr7:2030301 MAD1L1 0.33 9.1 0.34 1.09e-18 Bipolar disorder and schizophrenia; BRCA cis rs11105306 1 rs11105306 chr12:89897388 C/T cg00757033 chr12:89920650 WDR51B 0.54 11.07 0.4 3.53e-26 NT-proBNP levels in acute coronary syndrome; BRCA cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg24399712 chr22:39784796 NA -0.58 -13.4 -0.47 2.79e-36 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.39 -0.32 3.09e-16 Total body bone mineral density; BRCA cis rs7914558 1.000 rs11191541 chr10:104824199 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.42 0.38 1.4e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs3106136 0.527 rs2632410 chr4:95149507 A/T cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.08 -0.37 2.85e-22 Capecitabine sensitivity; BRCA cis rs208520 0.545 rs6899712 chr6:66749670 T/C cg07460842 chr6:66804631 NA 1.01 27.16 0.73 1.4e-108 Exhaled nitric oxide output; BRCA cis rs7737355 0.947 rs7706785 chr5:130954860 T/C cg06307176 chr5:131281290 NA 0.52 10.03 0.37 4.47e-22 Life satisfaction; BRCA cis rs2075371 0.933 rs1421480 chr7:133958114 A/C cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.42e-68 Mean platelet volume; BRCA cis rs7258465 0.931 rs875396 chr19:18611147 A/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.34 -0.31 4.74e-16 Breast cancer; BRCA cis rs2073300 0.609 rs8183135 chr20:23384284 C/T cg12062639 chr20:23401060 NAPB 0.95 13.22 0.46 1.89e-35 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg00166722 chr3:10149974 C3orf24 0.6 12.19 0.43 6.74e-31 Alzheimer's disease; BRCA cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.35 0.35 1.45e-19 Parkinson's disease; BRCA cis rs11971779 0.680 rs17691238 chr7:139052284 A/G cg07862535 chr7:139043722 LUC7L2 -0.36 -9.75 -0.36 5.04e-21 Diisocyanate-induced asthma; BRCA cis rs6496932 0.563 rs2344083 chr15:85897432 T/C cg10818794 chr15:86012489 AKAP13 -0.32 -8.3 -0.31 6.08e-16 Central corneal thickness;Corneal structure; BRCA trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.89 -0.3 1.27e-14 Corneal astigmatism; BRCA cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg01579765 chr21:45077557 HSF2BP -0.33 -8.78 -0.33 1.45e-17 Mean corpuscular volume; BRCA cis rs27434 0.583 rs151954 chr5:96157689 A/G cg16492584 chr5:96139282 ERAP1 -0.5 -12.76 -0.45 2.31e-33 Ankylosing spondylitis; BRCA cis rs6963495 0.818 rs73190200 chr7:105165856 T/C cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs867371 1.000 rs2088858 chr15:82474749 C/T cg00614314 chr15:82944287 LOC80154 0.43 9.09 0.34 1.21e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs854765 0.647 rs854769 chr17:18019011 A/G cg04398451 chr17:18023971 MYO15A 0.82 18.98 0.6 5e-64 Total body bone mineral density; BRCA cis rs7809950 0.678 rs2237661 chr7:106863123 T/C cg23024343 chr7:107201750 COG5 -0.44 -8.84 -0.33 9.37e-18 Coronary artery disease; BRCA cis rs7077164 1.000 rs1227764 chr10:71583223 G/A cg07630274 chr10:71583235 COL13A1 -0.25 -8.41 -0.32 2.71e-16 Non-alcoholic fatty liver disease histology (lobular); BRCA trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA cis rs9790314 0.605 rs13089559 chr3:160641688 T/A cg03342759 chr3:160939853 NMD3 0.45 8.74 0.33 2.1e-17 Morning vs. evening chronotype; BRCA trans rs62103177 0.525 rs8086024 chr18:77746623 A/G cg05926928 chr17:57297772 GDPD1 -0.6 -9.32 -0.35 1.86e-19 Opioid sensitivity; BRCA cis rs2153535 0.584 rs62395677 chr6:8371589 G/A cg23788917 chr6:8435910 SLC35B3 -0.43 -9.27 -0.34 2.91e-19 Motion sickness; BRCA cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg01939980 chr4:1354348 KIAA1530 0.35 9.28 0.34 2.52e-19 Longevity; BRCA trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg22491629 chr6:157744540 C6orf35 -0.67 -12.57 -0.45 1.59e-32 Hemostatic factors and hematological phenotypes; BRCA cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg14196790 chr5:131705035 SLC22A5 0.31 8.05 0.3 4.16e-15 Blood metabolite levels; BRCA cis rs35146811 0.735 rs858512 chr7:99824453 A/G cg22906224 chr7:99728672 NA -0.42 -7.98 -0.3 6.88e-15 Coronary artery disease; BRCA cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg23711669 chr6:146136114 FBXO30 0.77 17.59 0.57 9.28e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs3862260 0.509 rs3862262 chr1:120161841 G/T cg16322792 chr1:120165303 ZNF697 0.58 15.08 0.51 3.41e-44 Systemic lupus erythematosus; BRCA cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg02574844 chr11:5959923 NA -0.42 -8.27 -0.31 7.94e-16 DNA methylation (variation); BRCA cis rs67460515 0.892 rs34896809 chr3:161059804 C/T cg03342759 chr3:160939853 NMD3 -0.81 -19.09 -0.6 1.33e-64 Parkinson's disease; BRCA cis rs4727027 0.833 rs2107846 chr7:148832774 G/A cg23583168 chr7:148888333 NA -0.84 -19.54 -0.61 5.16e-67 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs34891900 0.507 rs1008378 chr22:18207251 T/C cg19898043 chr22:18121309 BCL2L13 0.46 9.43 0.35 7.55e-20 Sum neutrophil eosinophil counts; BRCA cis rs4481887 1.000 rs4916128 chr1:248466706 G/A cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.79e-18 Common traits (Other); BRCA cis rs559928 0.597 rs11600667 chr11:63976183 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.52 0.41 5.18e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs10484885 0.690 rs292236 chr6:90528422 A/G cg13799429 chr6:90582589 CASP8AP2 -0.79 -12.37 -0.44 1.19e-31 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4689388 0.926 rs9998835 chr4:6293237 C/G cg00701064 chr4:6280414 WFS1 0.68 17.63 0.57 5.82e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.31 -0.31 5.64e-16 Total body bone mineral density; BRCA cis rs66887589 0.616 rs11098498 chr4:120187119 T/C cg09307838 chr4:120376055 NA 0.47 9.77 0.36 4.19e-21 Diastolic blood pressure; BRCA cis rs1003719 0.715 rs2835667 chr21:38579914 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.51 -0.5 1.83e-41 Eye color traits; BRCA cis rs10733682 0.633 rs869500 chr9:129465898 G/A cg00232160 chr9:129468157 NA 0.41 9.45 0.35 6.48e-20 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs709400 0.859 rs7154948 chr14:104022944 C/T cg12935359 chr14:103987150 CKB -0.48 -10.98 -0.4 7.94e-26 Body mass index; BRCA cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.71e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9814567 1.000 rs1498718 chr3:134205920 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.36 -0.61 4.51e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg07493874 chr5:1342172 CLPTM1L -0.46 -13.04 -0.46 1.21e-34 Lung cancer; BRCA cis rs116095464 0.558 rs9312979 chr5:222057 A/C cg22496380 chr5:211416 CCDC127 -0.99 -14.41 -0.5 5.83e-41 Breast cancer; BRCA trans rs2270927 0.510 rs34596551 chr5:75577143 C/T cg13563193 chr19:33072644 PDCD5 0.87 10.18 0.37 1.16e-22 Mean corpuscular volume; BRCA trans rs11098499 0.954 rs12510138 chr4:120423935 C/G cg25517755 chr10:38738941 LOC399744 -0.37 -7.94 -0.3 8.93e-15 Corneal astigmatism; BRCA cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg03146154 chr1:46216737 IPP 0.45 9.87 0.36 1.72e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs751728 0.687 rs943479 chr6:33752013 A/G cg25922239 chr6:33757077 LEMD2 0.49 12.55 0.44 1.92e-32 Crohn's disease; BRCA cis rs11955398 0.669 rs11952735 chr5:59939146 T/C cg02684056 chr5:59996105 DEPDC1B 0.38 9.31 0.35 1.94e-19 Intelligence (multi-trait analysis); BRCA cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg10932868 chr11:921992 NA 0.39 9.6 0.36 1.75e-20 Alzheimer's disease (late onset); BRCA trans rs6598955 0.671 rs12142535 chr1:26589698 T/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg16606324 chr3:10149918 C3orf24 -0.58 -11.42 -0.41 1.34e-27 Alzheimer's disease; BRCA cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.27 0.31 7.93e-16 Aortic root size; BRCA cis rs9296092 0.521 rs6929165 chr6:33515958 T/G cg13560919 chr6:33536144 NA -0.74 -15.8 -0.53 1.08e-47 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA trans rs35110281 0.720 rs162372 chr21:44928863 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -10.13 -0.37 1.77e-22 Mean corpuscular volume; BRCA cis rs524281 0.861 rs7929909 chr11:65951698 C/T cg16950941 chr11:66035639 RAB1B -0.38 -8.0 -0.3 5.97e-15 Electroencephalogram traits; BRCA cis rs1008375 1.000 rs11722037 chr4:17683811 G/A cg15017067 chr4:17643749 FAM184B 0.32 9.67 0.36 9.73e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10411936 0.626 rs8113060 chr19:16596795 G/C cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.73 0.36 6.06e-21 White blood cell count;Multiple sclerosis; BRCA cis rs12612619 0.732 rs11688708 chr2:27199608 T/G cg00617064 chr2:27272375 NA -0.31 -8.22 -0.31 1.12e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.54 0.38 4.71e-24 Mean corpuscular volume; BRCA cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg20607798 chr8:58055168 NA 0.46 8.04 0.3 4.35e-15 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg11764359 chr7:65958608 NA -0.61 -10.38 -0.38 1.95e-23 Aortic root size; BRCA trans rs3960554 0.808 rs60481386 chr7:75700962 A/G cg19862616 chr7:65841803 NCRNA00174 0.56 12.08 0.43 2.11e-30 Eotaxin levels; BRCA cis rs2318131 0.505 rs4663691 chr2:237900552 A/G cg01069648 chr2:237906688 NA 0.37 8.08 0.3 3.27e-15 Motion sickness; BRCA trans rs2262909 0.962 rs436662 chr19:22232107 C/T cg17074339 chr11:11642133 GALNTL4 -0.41 -7.98 -0.3 6.96e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg13114125 chr14:105738426 BRF1 -0.54 -11.47 -0.41 8.22e-28 Mean platelet volume;Platelet distribution width; BRCA cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs3749237 1.000 rs2291542 chr3:49751585 C/T cg03060546 chr3:49711283 APEH 0.46 9.7 0.36 7.76e-21 Resting heart rate; BRCA cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg15017067 chr4:17643749 FAM184B 0.32 9.86 0.36 1.92e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.53 -0.44 2.36e-32 Bipolar disorder; BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg13628971 chr7:2884303 GNA12 0.47 9.44 0.35 6.73e-20 Height; BRCA cis rs4588572 0.643 rs10063319 chr5:77758425 T/C cg11547950 chr5:77652471 NA -0.48 -8.41 -0.32 2.77e-16 Triglycerides; BRCA cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.42e-34 Alzheimer's disease (late onset); BRCA cis rs7582180 0.629 rs12989897 chr2:100940998 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.67 0.42 1.21e-28 Intelligence (multi-trait analysis); BRCA cis rs12618769 0.652 rs17033813 chr2:99196483 A/G cg10123293 chr2:99228465 UNC50 -0.42 -8.4 -0.32 2.86e-16 Bipolar disorder; BRCA trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg23533926 chr12:111358616 MYL2 -0.42 -8.84 -0.33 9.21e-18 Extrinsic epigenetic age acceleration; BRCA cis rs35146811 0.700 rs4729579 chr7:99780282 C/G cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.37 -0.41 2.06e-27 Schizophrenia; BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg25036284 chr2:26402008 FAM59B -0.69 -11.12 -0.4 2.25e-26 Gut microbiome composition (summer); BRCA cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 11.23 0.41 7.54e-27 Systemic lupus erythematosus; BRCA cis rs12579753 0.913 rs17749243 chr12:82178079 A/C cg07988820 chr12:82153109 PPFIA2 -0.58 -9.34 -0.35 1.53e-19 Resting heart rate; BRCA cis rs2836974 0.932 rs2836955 chr21:40619887 G/A cg17971929 chr21:40555470 PSMG1 0.76 16.33 0.54 2.32e-50 Cognitive function; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg21782813 chr7:2030301 MAD1L1 0.41 10.83 0.39 3.14e-25 Bipolar disorder and schizophrenia; BRCA cis rs370915 0.564 rs10027461 chr4:187837608 T/C cg19519643 chr4:187840862 NA -0.37 -8.7 -0.33 2.82e-17 Gout; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg05342682 chr7:94953680 PON1 -0.4 -9.98 -0.37 6.71e-22 Paraoxonase activity; BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg12564285 chr5:131593104 PDLIM4 -0.39 -9.97 -0.37 7.2e-22 Acylcarnitine levels; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs11098499 0.754 rs10518300 chr4:120249499 G/T cg09307838 chr4:120376055 NA -0.62 -13.05 -0.46 1.13e-34 Corneal astigmatism; BRCA cis rs881375 0.933 rs4837799 chr9:123668326 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.47 0.32 1.68e-16 Rheumatoid arthritis; BRCA cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.67 0.45 5.84e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9875589 0.509 rs2731336 chr3:14091908 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.99 0.34 2.8e-18 Ovarian reserve; BRCA cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg05340658 chr4:99064831 C4orf37 0.65 16.04 0.54 6.49e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.546 rs10440329 chr4:98903735 C/T cg05340658 chr4:99064831 C4orf37 0.56 11.07 0.4 3.6e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg04553112 chr3:125709451 NA -0.55 -8.34 -0.31 4.41e-16 Blood pressure (smoking interaction); BRCA cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg24642439 chr20:33292090 TP53INP2 0.43 8.82 0.33 1.08e-17 Height; BRCA cis rs8141529 0.748 rs6005936 chr22:29289250 T/C cg02153584 chr22:29168773 CCDC117 0.56 11.68 0.42 1.02e-28 Lymphocyte counts; BRCA cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg17892150 chr10:133769511 PPP2R2D 0.71 15.72 0.53 2.57e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1609391 0.567 rs835633 chr3:136676496 T/C cg21827317 chr3:136751795 NA 0.35 7.88 0.3 1.44e-14 Neuroticism; BRCA cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg26384229 chr12:38710491 ALG10B -0.61 -14.39 -0.49 7.43e-41 Bladder cancer; BRCA cis rs4363385 0.818 rs2879487 chr1:152985360 C/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.74 -0.33 2.1e-17 Inflammatory skin disease; BRCA cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg07917127 chr4:99064746 C4orf37 0.44 8.0 0.3 6.01e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.26 -0.31 8.29e-16 Gut microbiome composition (summer); BRCA cis rs8044868 0.586 rs7199261 chr16:72082788 A/G cg16558253 chr16:72132732 DHX38 -0.45 -10.76 -0.39 6.27e-25 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg24642844 chr7:1081250 C7orf50 -0.6 -12.35 -0.44 1.46e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg07930192 chr7:1003750 NA 0.39 8.48 0.32 1.51e-16 Longevity;Endometriosis; BRCA cis rs7246657 0.943 rs4452075 chr19:37879589 A/G cg23950597 chr19:37808831 NA -0.62 -11.33 -0.41 3.02e-27 Coronary artery calcification; BRCA trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21659725 chr3:3221576 CRBN 0.71 21.69 0.65 1.41e-78 Intelligence (multi-trait analysis); BRCA cis rs801193 0.660 rs10950049 chr7:66230860 T/C cg18876405 chr7:65276391 NA 0.52 12.14 0.43 1.11e-30 Aortic root size; BRCA cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg17328964 chr8:145687451 CYHR1 0.64 15.62 0.53 8.24e-47 Age at first birth; BRCA cis rs17052344 0.543 rs2342183 chr17:21738349 G/T cg18423549 chr17:21743878 NA -0.64 -13.83 -0.48 3.02e-38 Cutaneous psoriasis; BRCA cis rs921968 0.643 rs545779 chr2:219336108 A/G cg02176678 chr2:219576539 TTLL4 0.39 10.42 0.38 1.35e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs4561483 0.801 rs8061189 chr16:11951749 C/G cg08843971 chr16:11963173 GSPT1 0.51 11.41 0.41 1.42e-27 Testicular germ cell tumor; BRCA cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.03e-34 Glomerular filtration rate (creatinine); BRCA cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.14e-16 Monocyte percentage of white cells; BRCA cis rs61990749 0.597 rs1048147 chr14:78139988 C/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.63 -9.61 -0.36 1.65e-20 Fibroblast growth factor basic levels; BRCA cis rs2953174 0.786 rs2953177 chr2:241516616 A/G cg07929629 chr2:241523174 NA 0.49 8.62 0.32 5.31e-17 Bipolar disorder; BRCA cis rs6964587 1.000 rs2301559 chr7:91746727 T/C cg17063962 chr7:91808500 NA 0.54 12.82 0.45 1.26e-33 Breast cancer; BRCA cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.47 -8.22 -0.31 1.12e-15 Multiple sclerosis; BRCA cis rs56399783 0.614 rs11772508 chr7:2771504 A/C cg23627948 chr7:2760692 NA -0.48 -8.04 -0.3 4.45e-15 Childhood ear infection; BRCA cis rs1883415 0.534 rs760905 chr6:24479782 T/C cg20631270 chr6:24437470 GPLD1 0.4 8.16 0.31 1.78e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg00149659 chr3:10157352 C3orf10 0.69 10.32 0.38 3.26e-23 Alzheimer's disease; BRCA cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg13114125 chr14:105738426 BRF1 0.54 11.39 0.41 1.78e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg07636037 chr3:49044803 WDR6 0.98 28.74 0.75 3.03e-117 Parkinson's disease; BRCA cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs56159542 1 rs56159542 chr19:19682971 T/C cg15839431 chr19:19639596 YJEFN3 0.38 8.4 0.32 2.8e-16 Attention deficit hyperactivity disorder symptom score; BRCA cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.44 -0.35 6.97e-20 Tonsillectomy; BRCA cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg27624424 chr6:160112604 SOD2 -0.37 -8.06 -0.3 3.66e-15 Age-related macular degeneration (geographic atrophy); BRCA cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg16179182 chr5:140090404 VTRNA1-1 0.42 9.69 0.36 8.56e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs394563 0.591 rs237018 chr6:149743930 A/G cg03678062 chr6:149772716 ZC3H12D -0.29 -7.81 -0.3 2.33e-14 Dupuytren's disease; BRCA cis rs12586317 0.620 rs58320987 chr14:35587726 T/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.44 -0.38 1.13e-23 Psoriasis; BRCA cis rs3768617 0.706 rs6678517 chr1:183002639 A/G ch.1.3577855R chr1:183094577 LAMC1 0.49 11.28 0.41 4.89e-27 Fuchs's corneal dystrophy; BRCA cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg23711669 chr6:146136114 FBXO30 -0.74 -15.34 -0.52 1.93e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.931 rs10939734 chr4:17570709 C/T cg16339924 chr4:17578868 LAP3 0.67 16.57 0.55 1.5e-51 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10197940 0.578 rs1061305 chr2:152346979 T/C cg19508488 chr2:152266495 RIF1 0.38 8.23 0.31 1.03e-15 Lung cancer; BRCA trans rs11722228 0.549 rs73212863 chr4:10104173 C/T cg26043149 chr18:55253948 FECH 1.1 23.69 0.68 1.63e-89 Gout;Urate levels;Serum uric acid levels; BRCA cis rs2762353 0.935 rs1165213 chr6:25799676 A/G cg03264133 chr6:25882463 NA 0.49 11.12 0.4 2.24e-26 Blood metabolite levels; BRCA cis rs4845875 0.535 rs198408 chr1:11898130 T/A cg24844545 chr1:11908347 NPPA -0.31 -8.08 -0.3 3.13e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs875971 1.000 rs1544549 chr7:66090663 T/A cg18876405 chr7:65276391 NA -0.54 -12.55 -0.44 1.94e-32 Aortic root size; BRCA cis rs4363385 0.747 rs2339494 chr1:152975143 G/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.01 -0.34 2.4e-18 Inflammatory skin disease; BRCA cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs7737355 0.645 rs184950 chr5:130852847 G/A cg06307176 chr5:131281290 NA 0.53 10.72 0.39 8.97e-25 Life satisfaction; BRCA cis rs8114671 0.562 rs6088635 chr20:33466501 A/G cg24642439 chr20:33292090 TP53INP2 0.42 8.28 0.31 7.48e-16 Height; BRCA cis rs12586317 0.553 rs78124218 chr14:35570606 G/A cg16230307 chr14:35515116 FAM177A1 0.69 14.26 0.49 3.01e-40 Psoriasis; BRCA cis rs4853036 0.951 rs13393656 chr2:70119255 C/A cg02498382 chr2:70120550 SNRNP27 -0.54 -10.62 -0.39 2.32e-24 Colorectal or endometrial cancer; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg22920501 chr2:26401640 FAM59B -0.81 -13.19 -0.46 2.66e-35 Gut microbiome composition (summer); BRCA cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg18904891 chr8:8559673 CLDN23 -0.65 -12.98 -0.46 2.36e-34 Obesity-related traits; BRCA cis rs724568 0.509 rs10179159 chr2:67923516 T/C cg17945962 chr2:67939740 NA -0.36 -9.14 -0.34 8.32e-19 Major depressive disorder (broad); BRCA cis rs17401966 1.000 rs11121533 chr1:10292888 G/C cg15208524 chr1:10270712 KIF1B 0.37 8.24 0.31 9.770000000000001e-16 Hepatocellular carcinoma; BRCA trans rs7746199 0.736 rs13215275 chr6:27647509 G/T cg01620082 chr3:125678407 NA -0.92 -10.33 -0.38 2.97e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA trans rs1459104 1.000 rs35097999 chr11:55048103 C/T cg15704280 chr7:45808275 SEPT13 0.69 8.57 0.32 7.47e-17 Body mass index; BRCA trans rs208520 0.526 rs6455072 chr6:66797215 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -38.88 -0.84 1.45e-170 Exhaled nitric oxide output; BRCA cis rs4363385 0.747 rs1577964 chr1:152961784 C/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.04 -0.3 4.39e-15 Inflammatory skin disease; BRCA cis rs2066819 1.000 rs41392645 chr12:56696742 A/G cg26734620 chr12:56694298 CS 0.87 10.24 0.38 6.61e-23 Psoriasis vulgaris; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs495337 0.662 rs6020072 chr20:48445454 A/G cg17835207 chr20:48524531 SPATA2 0.52 11.9 0.43 1.26e-29 Psoriasis; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.54 10.53 0.38 5.11e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7528419 1.000 rs646776 chr1:109818530 C/T cg00908766 chr1:109817496 CELSR2 0.62 19.4 0.61 2.87e-66 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; BRCA cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg13395646 chr4:1353034 KIAA1530 -0.51 -9.13 -0.34 9.19e-19 Obesity-related traits; BRCA trans rs1422110 0.879 rs1363268 chr5:85469695 C/T cg01787110 chr1:109008453 NBPF6 -0.44 -8.84 -0.33 9.59e-18 Attention function in attention deficit hyperactive disorder; BRCA cis rs10751667 0.666 rs10902255 chr11:967268 T/C cg01483505 chr11:975446 AP2A2 0.33 9.07 0.34 1.44e-18 Alzheimer's disease (late onset); BRCA cis rs4237845 0.513 rs7134797 chr12:58263852 C/T cg00677455 chr12:58241039 CTDSP2 0.62 14.45 0.5 3.59e-41 Intelligence (multi-trait analysis); BRCA cis rs1113500 0.787 rs12047429 chr1:108633239 C/T cg06207961 chr1:108661230 NA 0.36 8.89 0.33 6.4e-18 Growth-regulated protein alpha levels; BRCA cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.49e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.02e-40 Motion sickness; BRCA cis rs10911232 0.507 rs4642853 chr1:182996242 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.69 0.55 3.67e-52 Hypertriglyceridemia; BRCA cis rs7103648 1.000 rs2293579 chr11:47440758 G/A cg20307385 chr11:47447363 PSMC3 0.89 26.28 0.72 9.8e-104 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6504950 0.705 rs17745123 chr17:52988232 G/T cg26251398 chr17:52985966 TOM1L1 0.32 8.22 0.31 1.1e-15 Breast cancer; BRCA cis rs4242434 0.672 rs10110443 chr8:22484296 C/G cg03733263 chr8:22462867 KIAA1967 0.78 18.0 0.58 6.91e-59 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs853679 0.598 rs9380054 chr6:28067537 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.49e-15 Depression; BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.51 0.38 6.29e-24 Tonsillectomy; BRCA cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg10295955 chr4:187884368 NA -0.99 -31.58 -0.78 1.4e-132 Lobe attachment (rater-scored or self-reported); BRCA cis rs61931739 0.517 rs10844738 chr12:34059503 T/A cg06521331 chr12:34319734 NA -0.63 -12.48 -0.44 3.67e-32 Morning vs. evening chronotype; BRCA cis rs2354432 0.607 rs4950385 chr1:146656292 A/G cg25205988 chr1:146714368 CHD1L 0.86 10.43 0.38 1.23e-23 Mitochondrial DNA levels; BRCA cis rs250677 0.522 rs4705301 chr5:148354902 C/G cg12140854 chr5:148520817 ABLIM3 -0.39 -7.97 -0.3 7.41e-15 Breast cancer; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.79 -0.33 1.35e-17 Total body bone mineral density; BRCA cis rs2243480 0.708 rs35310401 chr7:65390359 A/G cg18252515 chr7:66147081 NA -0.84 -12.14 -0.43 1.2e-30 Diabetic kidney disease; BRCA cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg09658497 chr7:2847517 GNA12 -0.45 -9.9 -0.36 1.35e-21 Height; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.03 18.68 0.59 1.84e-62 Gut microbiome composition (summer); BRCA cis rs614226 1.000 rs614226 chr12:120974510 C/T cg01236616 chr12:121019343 POP5 -1.24 -25.05 -0.7 5.12e-97 Type 1 diabetes nephropathy; BRCA cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg10802521 chr3:52805072 NEK4 -0.33 -8.58 -0.32 7.26e-17 Bipolar disorder; BRCA cis rs911119 0.955 rs6048952 chr20:23607257 A/G cg16589663 chr20:23618590 CST3 0.4 8.2 0.31 1.34e-15 Chronic kidney disease; BRCA trans rs9467711 0.659 rs34605993 chr6:26454363 C/T cg01620082 chr3:125678407 NA -0.72 -8.46 -0.32 1.78e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs61931739 0.534 rs4931775 chr12:34050729 G/A cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.44e-26 Morning vs. evening chronotype; BRCA cis rs6582630 0.638 rs12425379 chr12:38523705 G/A cg26384229 chr12:38710491 ALG10B -0.43 -10.12 -0.37 2.03e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg11814155 chr7:99998594 ZCWPW1 0.48 8.7 0.33 2.76e-17 Platelet count; BRCA cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg03517284 chr6:25882590 NA -0.47 -9.81 -0.36 2.88e-21 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.87 0.36 1.77e-21 Tonsillectomy; BRCA cis rs1878931 0.582 rs4785933 chr16:3419741 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.51 8.76 0.33 1.79e-17 Body mass index (adult); BRCA cis rs6701037 0.782 rs12760073 chr1:175139295 G/T cg14847009 chr1:175162515 KIAA0040 -0.24 -8.86 -0.33 7.64e-18 Alcohol dependence; BRCA cis rs9300255 0.770 rs7980687 chr12:123822711 G/A cg00376283 chr12:123451042 ABCB9 -0.52 -11.2 -0.41 9.95e-27 Neutrophil percentage of white cells; BRCA cis rs36051895 0.632 rs10974982 chr9:5149382 G/C cg02405213 chr9:5042618 JAK2 -0.45 -8.61 -0.32 5.67e-17 Pediatric autoimmune diseases; BRCA cis rs2425143 0.598 rs2425118 chr20:34324098 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Blood protein levels; BRCA cis rs875971 1.000 rs6961155 chr7:65933295 T/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg16325326 chr1:53192061 ZYG11B 0.89 24.61 0.7 1.43e-94 Monocyte count; BRCA cis rs28735056 1.000 rs28735056 chr18:77622879 A/G cg03682112 chr18:77623598 KCNG2 -0.37 -8.48 -0.32 1.6e-16 Schizophrenia; BRCA cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg03264133 chr6:25882463 NA -0.58 -11.86 -0.42 1.83e-29 Intelligence (multi-trait analysis); BRCA cis rs10992471 0.756 rs10992303 chr9:95082804 A/G cg14631576 chr9:95140430 CENPP -0.37 -8.97 -0.33 3.22e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs6582630 0.519 rs4002438 chr12:38484880 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs651907 0.712 rs796410 chr3:101610189 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.36 9.21 0.34 4.47e-19 Colorectal cancer; BRCA cis rs3820928 1.000 rs978909 chr2:227771389 A/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.75 -0.33 1.82e-17 Pulmonary function; BRCA trans rs9325144 0.600 rs12297194 chr12:38735803 A/G cg23762105 chr12:34175262 ALG10 0.38 9.66 0.36 1.06e-20 Morning vs. evening chronotype; BRCA cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 13.42 0.47 2.39e-36 Eosinophil percentage of white cells; BRCA cis rs17376456 0.569 rs7701114 chr5:93096028 T/C cg25358565 chr5:93447407 FAM172A 0.7 12.13 0.43 1.23e-30 Diabetic retinopathy; BRCA trans rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05039488 chr6:79577232 IRAK1BP1 0.36 7.99 0.3 6.53e-15 Endometrial cancer; BRCA cis rs708547 0.697 rs67479587 chr4:57878884 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.82 0.36 2.67e-21 Response to bleomycin (chromatid breaks); BRCA cis rs72781680 0.898 rs17462558 chr2:24020812 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs4363385 0.818 rs1048296 chr1:153012240 A/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs16866061 1.000 rs10498163 chr2:225434445 A/G cg12698349 chr2:225449008 CUL3 0.78 21.19 0.64 6.7e-76 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs12472274 0.941 rs4663861 chr2:239105203 C/T cg17459225 chr2:239074497 NA 0.63 12.88 0.45 6.5e-34 Phospholipid levels (plasma); BRCA cis rs6089584 0.528 rs881994 chr20:60623931 G/A cg06108461 chr20:60628389 TAF4 -0.74 -15.41 -0.52 8.19e-46 Body mass index; BRCA trans rs1005277 0.522 rs200943 chr10:38148730 A/G cg17830980 chr10:43048298 ZNF37B -0.42 -9.91 -0.36 1.23e-21 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA trans rs561341 1.000 rs527256 chr17:30321293 C/G cg20587970 chr11:113659929 NA -1.24 -22.64 -0.67 8.57e-84 Hip circumference adjusted for BMI; BRCA cis rs757081 0.637 rs586785 chr11:17208714 T/C cg15432903 chr11:17409602 KCNJ11 -0.45 -8.46 -0.32 1.78e-16 Systolic blood pressure; BRCA trans rs2204008 0.774 rs11616004 chr12:38278822 G/A cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs4713118 0.868 rs35069907 chr6:27746692 T/C cg20933634 chr6:27740509 NA 0.44 8.22 0.31 1.11e-15 Parkinson's disease; BRCA trans rs35110281 0.574 rs1836856 chr21:44964638 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.83 0.33 1e-17 Mean corpuscular volume; BRCA cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.69 16.12 0.54 2.57e-49 Axial length; BRCA trans rs208515 0.525 rs12193034 chr6:66677866 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.05 0.54 5.66e-49 Exhaled nitric oxide levels; BRCA cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg08847533 chr14:75593920 NEK9 0.46 8.51 0.32 1.28e-16 Caffeine consumption; BRCA cis rs847649 0.621 rs2222539 chr7:102674786 G/A cg18108683 chr7:102477205 FBXL13 0.36 7.94 0.3 9.36e-15 Morning vs. evening chronotype; BRCA cis rs1348850 0.872 rs4893825 chr2:178298687 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 8.36 0.31 3.82e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9814567 0.929 rs1534027 chr3:134284662 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.56 -0.61 4.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -9.03 -0.34 1.99e-18 Alzheimer's disease (late onset); BRCA cis rs1499614 1.000 rs60326618 chr7:66166358 G/A cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA trans rs9951602 0.512 rs4799245 chr18:76653397 T/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.23 0.58 4.3e-60 Obesity-related traits; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.03 0.34 2.04e-18 Platelet count; BRCA cis rs4566357 0.615 rs3769643 chr2:227917270 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -9.55 -0.35 2.65e-20 Coronary artery disease; BRCA cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg06784218 chr1:46089804 CCDC17 0.5 11.89 0.43 1.32e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.92 0.3 1.03e-14 Corneal astigmatism; BRCA cis rs9788682 0.747 rs2656069 chr15:78745707 C/T cg24631222 chr15:78858424 CHRNA5 -0.5 -10.01 -0.37 5.19e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg13798912 chr7:905769 UNC84A -0.5 -7.88 -0.3 1.42e-14 Cerebrospinal P-tau181p levels; BRCA cis rs1355223 0.525 rs12280958 chr11:34872799 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs17270561 0.609 rs9348695 chr6:25763010 A/T cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs11249608 0.548 rs10479520 chr5:178451447 C/A cg21905437 chr5:178450457 ZNF879 0.51 10.78 0.39 5.39e-25 Pubertal anthropometrics; BRCA cis rs11690935 0.959 rs6754817 chr2:172663394 C/T cg13550731 chr2:172543902 DYNC1I2 -0.87 -26.37 -0.72 2.97e-104 Schizophrenia; BRCA cis rs6665290 0.669 rs3768424 chr1:227177444 A/G cg10327440 chr1:227177885 CDC42BPA -1.09 -38.67 -0.84 1.67e-169 Myeloid white cell count; BRCA cis rs3857067 0.806 rs4693001 chr4:95115097 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs35110281 0.805 rs2838318 chr21:44991825 G/A cg04455712 chr21:45112962 RRP1B 0.39 10.3 0.38 4.21e-23 Mean corpuscular volume; BRCA cis rs1801251 1.000 rs4973055 chr2:233720283 G/T cg25237894 chr2:233734115 C2orf82 -0.41 -11.82 -0.42 2.77e-29 Coronary artery disease; BRCA cis rs16976116 0.901 rs1061822 chr15:55496058 A/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg00101154 chr16:420108 MRPL28 0.45 11.02 0.4 5.74e-26 Bone mineral density (spine);Bone mineral density; BRCA cis rs6912958 0.678 rs9450733 chr6:88250081 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.82e-16 Monocyte percentage of white cells; BRCA cis rs72772090 0.539 rs55996659 chr5:96114150 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.32 -0.44 1.91e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs62380364 0.565 rs40504 chr5:88011139 G/C cg22951263 chr5:87985283 NA -0.38 -10.45 -0.38 1.08e-23 Intelligence (multi-trait analysis); BRCA cis rs2421770 0.530 rs6484784 chr11:35368347 A/C cg13971030 chr11:35366721 SLC1A2 0.43 9.35 0.35 1.41e-19 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs6714710 0.603 rs2044459 chr2:98447004 T/C cg26665480 chr2:98280029 ACTR1B 0.6 13.82 0.48 3.49e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg06547715 chr2:218990976 CXCR2 0.32 7.89 0.3 1.3e-14 Ulcerative colitis; BRCA cis rs9469578 1.000 rs9469578 chr6:33706479 C/T cg18708504 chr6:33715942 IP6K3 0.72 10.42 0.38 1.43e-23 Phosphorus levels; BRCA cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg04553112 chr3:125709451 NA -0.56 -8.5 -0.32 1.34e-16 Blood pressure (smoking interaction); BRCA cis rs35146811 0.735 rs858505 chr7:99819577 G/A cg13334819 chr7:99746414 C7orf59 0.4 9.04 0.34 1.84e-18 Coronary artery disease; BRCA cis rs1163251 0.902 rs839605 chr1:120217524 C/A cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs1878931 0.697 rs1044390 chr16:3432594 T/A cg26668626 chr16:3451006 ZNF174;ZNF434 1.0 26.98 0.73 1.26e-107 Body mass index (adult); BRCA cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs4481887 0.790 rs4382760 chr1:248422343 A/C cg00666640 chr1:248458726 OR2T12 -0.27 -7.99 -0.3 6.1e-15 Common traits (Other); BRCA cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.62 0.32 5.44e-17 Multiple sclerosis; BRCA cis rs4268898 0.662 rs72795832 chr2:24441855 C/A cg06627628 chr2:24431161 ITSN2 -0.8 -15.37 -0.52 1.35e-45 Asthma; BRCA cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.42 -8.42 -0.32 2.49e-16 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg19678392 chr7:94953810 PON1 -0.41 -8.88 -0.33 6.78e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 7.97 0.3 7.09e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3925075 0.531 rs7206295 chr16:31336519 T/C cg02846316 chr16:31340340 ITGAM 0.43 8.61 0.32 5.71e-17 IgA nephropathy; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4803468 0.967 rs13344547 chr19:41945848 G/T cg09537434 chr19:41945824 ATP5SL 1.02 25.43 0.71 4.25e-99 Height; BRCA cis rs3768617 0.510 rs10752896 chr1:183068516 A/C ch.1.3577855R chr1:183094577 LAMC1 0.68 17.64 0.57 4.83e-57 Fuchs's corneal dystrophy; BRCA cis rs7666738 0.800 rs7683737 chr4:99070880 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.61 0.39 2.44e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg08975724 chr8:8085496 FLJ10661 0.42 9.27 0.34 2.73e-19 Mood instability; BRCA cis rs12464559 0.522 rs10180065 chr2:152619007 A/G cg01189475 chr2:152685088 ARL5A -0.57 -8.52 -0.32 1.14e-16 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs34779708 0.931 rs11596502 chr10:35387187 A/C cg03585969 chr10:35415529 CREM 0.56 11.52 0.41 4.97e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg22535103 chr8:58192502 C8orf71 -0.49 -8.66 -0.32 3.91e-17 Developmental language disorder (linguistic errors); BRCA trans rs3780486 0.846 rs4584234 chr9:33147479 G/A cg04842962 chr6:43655489 MRPS18A 1.07 34.28 0.8 6.17e-147 IgG glycosylation; BRCA cis rs3796352 1.000 rs35849389 chr3:53005235 A/G cg07884673 chr3:53033167 SFMBT1 0.72 8.94 0.33 4.2e-18 Immune reponse to smallpox (secreted IL-2); BRCA cis rs1707322 1.000 rs1768800 chr1:46549188 A/G cg03146154 chr1:46216737 IPP -0.44 -9.62 -0.36 1.5e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg07148914 chr20:33460835 GGT7 -0.38 -8.7 -0.33 2.9e-17 Height; BRCA cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg11833968 chr6:79620685 NA -0.46 -10.44 -0.38 1.11e-23 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.875 rs10872582 chr6:146373061 G/A cg23711669 chr6:146136114 FBXO30 0.64 14.88 0.51 3.07e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.29 -0.38 4.53e-23 Alzheimer's disease (late onset); BRCA cis rs4664304 0.620 rs2048436 chr2:160712119 A/G cg01092293 chr2:160761427 LY75 0.36 8.52 0.32 1.14e-16 Crohn's disease;Inflammatory bowel disease; BRCA trans rs1493916 0.837 rs9952002 chr18:31414314 C/G cg27147174 chr7:100797783 AP1S1 -0.43 -8.73 -0.33 2.16e-17 Life satisfaction; BRCA cis rs73001065 0.591 rs56273306 chr19:19621004 T/C cg03709012 chr19:19516395 GATAD2A 1.01 14.22 0.49 4.65e-40 LDL cholesterol; BRCA cis rs4742903 0.904 rs10991187 chr9:106996271 C/T cg14250997 chr9:106856677 SMC2 0.3 9.61 0.36 1.58e-20 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2839186 0.934 rs17182538 chr21:47705673 C/A cg12379764 chr21:47803548 PCNT -0.37 -7.96 -0.3 7.88e-15 Testicular germ cell tumor; BRCA cis rs636291 0.517 rs11121579 chr1:10541824 G/C cg07384165 chr1:10488281 NA -0.41 -8.76 -0.33 1.77e-17 Prostate cancer; BRCA cis rs55692411 0.517 rs13095697 chr3:50136463 G/A cg05623727 chr3:50126028 RBM5 0.44 8.42 0.32 2.56e-16 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg13047869 chr3:10149882 C3orf24 0.61 12.82 0.45 1.18e-33 Alzheimer's disease; BRCA cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 9.13 0.34 9.17e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs870825 0.860 rs72703521 chr4:185603080 T/C cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs3760982 0.585 rs1386502 chr19:44293356 T/C cg12072164 chr19:44306565 LYPD5 0.37 8.8 0.33 1.32e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA trans rs6598955 1.000 rs10902728 chr1:26598281 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.35 -8.78 -0.33 1.5e-17 Obesity-related traits; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.97 -0.46 2.5e-34 Lymphocyte counts; BRCA cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg03213289 chr20:61660250 NA 0.62 16.4 0.54 1.09e-50 Prostate cancer (SNP x SNP interaction); BRCA trans rs35110281 0.693 rs2838344 chr21:45089877 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.12 0.31 2.32e-15 Mean corpuscular volume; BRCA cis rs2180341 0.782 rs6912006 chr6:127722631 C/T cg27446573 chr6:127587934 RNF146 0.63 13.85 0.48 2.56e-38 Breast cancer; BRCA trans rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.51 -11.72 -0.42 7.19e-29 Brugada syndrome; BRCA cis rs9287719 0.649 rs6720112 chr2:10725719 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA trans rs11098499 0.954 rs12505469 chr4:120249585 C/T cg25214090 chr10:38739885 LOC399744 0.52 11.78 0.42 4.13e-29 Corneal astigmatism; BRCA cis rs2370759 1.000 rs2370759 chr10:32634972 G/A cg18270830 chr10:32634957 EPC1 0.61 10.26 0.38 5.64e-23 Sexual dysfunction (female); BRCA cis rs9814567 1.000 rs7374158 chr3:134270156 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg17143192 chr8:8559678 CLDN23 -0.55 -10.78 -0.39 5.35e-25 Obesity-related traits; BRCA cis rs1005277 0.579 rs1740735 chr10:38497777 A/C cg00409905 chr10:38381863 ZNF37A -0.53 -11.4 -0.41 1.57e-27 Extrinsic epigenetic age acceleration; BRCA cis rs6840360 0.593 rs59350867 chr4:152695935 G/A cg22705602 chr4:152727874 NA -0.38 -10.54 -0.38 4.79e-24 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.863 rs1155576 chr4:120450159 A/C cg09307838 chr4:120376055 NA 0.69 14.85 0.51 4.67e-43 Corneal astigmatism; BRCA cis rs9393777 0.623 rs9366658 chr6:26469866 G/A cg12826209 chr6:26865740 GUSBL1 0.56 9.23 0.34 3.9e-19 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.822 rs79024594 chr14:56092997 T/G cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs208520 0.661 rs207099 chr6:66796373 A/C cg07460842 chr6:66804631 NA -1.01 -20.17 -0.62 2.18e-70 Exhaled nitric oxide output; BRCA cis rs6430585 0.702 rs1042712 chr2:136545844 C/G cg07169764 chr2:136633963 MCM6 -1.15 -25.92 -0.72 8.96e-102 Corneal structure; BRCA cis rs2204008 0.749 rs4579984 chr12:38166266 A/G cg26384229 chr12:38710491 ALG10B 0.66 15.1 0.51 2.91e-44 Bladder cancer; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13126279 chr21:47581558 C21orf56 0.5 10.75 0.39 6.84e-25 Testicular germ cell tumor; BRCA cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -10.19 -0.37 1.03e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs11711311 1.000 rs12736 chr3:113530211 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.38 9.75 0.36 4.76e-21 IgG glycosylation; BRCA cis rs2404602 0.716 rs1946650 chr15:76848463 T/C cg22467129 chr15:76604101 ETFA -0.48 -10.37 -0.38 2.23e-23 Blood metabolite levels; BRCA cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs507080 0.922 rs555356 chr11:118558078 G/T cg08498647 chr11:118550644 TREH -0.37 -8.11 -0.31 2.55e-15 Serum metabolite levels; BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg21747090 chr2:27597821 SNX17 -0.37 -7.86 -0.3 1.64e-14 Menopause (age at onset); BRCA cis rs9814567 1.000 rs2887797 chr3:134202506 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.26 -0.61 1.53e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs148387471 1 rs148387471 chr3:127057551 ATAG/A cg27326032 chr3:127006922 NA -0.53 -9.11 -0.34 1.09e-18 Interleukin-10 levels;Interleukin-13 levels; BRCA cis rs477895 1.000 rs7938380 chr11:64034866 G/A cg04317338 chr11:64019027 PLCB3 0.52 7.97 0.3 7.56e-15 Mean platelet volume; BRCA cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.29e-36 Mean platelet volume; BRCA cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.1 -0.34 1.15e-18 Alzheimer's disease (late onset); BRCA cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 15.18 0.51 1.16e-44 Colorectal cancer; BRCA cis rs13064411 0.518 rs1471884 chr3:113212041 G/A cg18753928 chr3:113234510 CCDC52 -0.41 -9.18 -0.34 6.13e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg05890377 chr2:74357713 NA 0.47 11.66 0.42 1.32e-28 Gestational age at birth (maternal effect); BRCA cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg21475434 chr5:93447410 FAM172A 0.61 7.97 0.3 7.32e-15 Diabetic retinopathy; BRCA trans rs9325144 0.647 rs35138700 chr12:38804474 C/T cg23762105 chr12:34175262 ALG10 0.35 8.15 0.31 1.98e-15 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.24 0.49 3.83e-40 Motion sickness; BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg19723775 chr5:179050963 HNRNPH1 0.36 8.54 0.32 9.75e-17 Lung cancer; BRCA cis rs8177253 0.507 rs4241357 chr3:133475563 A/C cg01448562 chr3:133502909 NA 0.34 8.0 0.3 5.78e-15 Iron status biomarkers; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg04727924 chr7:799746 HEATR2 -0.54 -9.32 -0.35 1.82e-19 Cerebrospinal P-tau181p levels; BRCA cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg08999081 chr20:33150536 PIGU 0.44 12.51 0.44 2.96e-32 Glomerular filtration rate (creatinine); BRCA cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg26528668 chr16:1614120 IFT140 0.36 8.23 0.31 1.06e-15 Coronary artery disease; BRCA cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg02466173 chr16:30829666 NA -0.64 -15.38 -0.52 1.2e-45 Dementia with Lewy bodies; BRCA cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.87 0.4 2.18e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg26446133 chr18:72167187 CNDP2 -0.79 -19.96 -0.62 3.06e-69 Refractive error; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg10729496 chr3:10149963 C3orf24 0.48 8.9 0.33 5.72e-18 Alzheimer's disease; BRCA cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg08085267 chr17:45401833 C17orf57 0.61 13.1 0.46 6.42e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs11098499 0.954 rs13145352 chr4:120409963 C/T cg25214090 chr10:38739885 LOC399744 -0.53 -11.86 -0.42 1.81e-29 Corneal astigmatism; BRCA cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.46 -0.35 5.73e-20 Developmental language disorder (linguistic errors); BRCA cis rs3820928 0.874 rs11685983 chr2:227799853 A/G cg11843606 chr2:227700838 RHBDD1 -0.39 -8.6 -0.32 6.39e-17 Pulmonary function; BRCA cis rs6835098 0.608 rs2332668 chr4:174163360 A/G cg08422745 chr4:174089978 GALNT7 -0.65 -13.37 -0.47 4.14e-36 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs79839061 0.610 rs12651271 chr4:854071 C/T cg07828340 chr4:882639 GAK 1.01 12.35 0.44 1.37e-31 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00166722 chr3:10149974 C3orf24 0.65 12.94 0.46 3.49e-34 Alzheimer's disease; BRCA cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg21918786 chr6:109611834 NA -0.34 -8.97 -0.33 3.25e-18 Reticulocyte fraction of red cells; BRCA cis rs11098499 0.863 rs7664986 chr4:120429952 A/C cg09307838 chr4:120376055 NA 0.7 14.19 0.49 5.99e-40 Corneal astigmatism; BRCA cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg08085267 chr17:45401833 C17orf57 -0.61 -12.41 -0.44 7.5e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA cis rs11098499 1.000 rs11098500 chr4:120219239 T/A cg09307838 chr4:120376055 NA 0.65 13.35 0.47 4.79e-36 Corneal astigmatism; BRCA cis rs943466 1.000 rs55775340 chr6:33751784 C/G cg25922239 chr6:33757077 LEMD2 -0.37 -8.04 -0.3 4.23e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg13877915 chr19:58951672 ZNF132 0.46 10.81 0.39 3.98e-25 Uric acid clearance; BRCA cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg12292205 chr6:26970375 C6orf41 -0.8 -19.53 -0.61 6.14e-67 Autism spectrum disorder or schizophrenia; BRCA cis rs10876993 0.928 rs2640637 chr12:58077586 G/A cg18357645 chr12:58087776 OS9 0.48 13.8 0.48 4.11e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.92 20.79 0.64 9.64e-74 Smoking behavior; BRCA cis rs698833 0.962 rs1065785 chr2:44660699 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.87 0.36 1.7e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9473147 0.516 rs7754971 chr6:47590476 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.65 0.36 1.21e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs9463078 0.764 rs976699 chr6:44952852 G/T cg25276700 chr6:44698697 NA -0.37 -8.54 -0.32 9.74e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9308433 0.529 rs1391553 chr1:214474119 T/C cg06198575 chr1:214491504 SMYD2 0.57 12.4 0.44 8.68e-32 IgG glycosylation; BRCA cis rs1568889 1.000 rs12796293 chr11:28177723 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.64 -14.02 -0.49 3.77e-39 Bipolar disorder; BRCA cis rs6433895 1.000 rs13033467 chr2:182016757 A/G cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs10484885 0.824 rs112817281 chr6:90555658 G/A cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.72 -0.36 6.63e-21 QRS interval (sulfonylurea treatment interaction); BRCA trans rs17685 0.712 rs1859792 chr7:75789264 T/C cg19862616 chr7:65841803 NCRNA00174 0.81 25.02 0.7 8.16e-97 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs55883249 1.000 rs62119428 chr2:9743332 T/C cg23886495 chr2:9695866 ADAM17 0.55 7.89 0.3 1.27e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg12310025 chr6:25882481 NA -0.52 -11.97 -0.43 6.14e-30 Intelligence (multi-trait analysis); BRCA cis rs3784262 0.679 rs11071366 chr15:58334244 A/T cg12031962 chr15:58353849 ALDH1A2 -0.54 -13.57 -0.47 4.7e-37 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg24531977 chr5:56204891 C5orf35 -0.86 -17.41 -0.57 7.19e-56 Initial pursuit acceleration; BRCA cis rs7100689 0.577 rs9420359 chr10:82054873 C/T cg01528321 chr10:82214614 TSPAN14 0.79 17.39 0.57 9.73e-56 Post bronchodilator FEV1; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg23978390 chr7:1156363 C7orf50 0.52 12.33 0.44 1.68e-31 Longevity;Endometriosis; BRCA cis rs2016266 0.787 rs4520636 chr12:53752133 G/T cg26875137 chr12:53738046 NA 0.43 10.92 0.4 1.37e-25 Bone mineral density (spine);Bone mineral density; BRCA cis rs7726839 0.561 rs11955068 chr5:582324 C/T cg09021430 chr5:549028 NA -0.64 -15.26 -0.52 4.49e-45 Obesity-related traits; BRCA cis rs12612619 0.732 rs1465881 chr2:27237614 A/G cg00617064 chr2:27272375 NA -0.31 -8.09 -0.3 2.9e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00149659 chr3:10157352 C3orf10 0.72 12.75 0.45 2.51e-33 Alzheimer's disease; BRCA cis rs470119 1.000 rs131801 chr22:50966634 G/T cg12969734 chr22:50962224 SCO2 0.38 9.15 0.34 7.3e-19 Mean corpuscular hemoglobin; BRCA cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg21918786 chr6:109611834 NA -0.44 -11.84 -0.42 2.33e-29 Reticulocyte fraction of red cells; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg25036284 chr2:26402008 FAM59B -0.79 -12.41 -0.44 7.62e-32 Gut microbiome composition (summer); BRCA cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg11168104 chr5:1857477 NA -0.34 -8.89 -0.33 6.07e-18 Cardiovascular disease risk factors; BRCA trans rs6582630 0.519 rs12582285 chr12:38298753 C/T cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.46e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs12042938 0.579 rs980394 chr1:231779507 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.39 -8.51 -0.32 1.26e-16 Neuranatomic and neurocognitive phenotypes; BRCA trans rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05039488 chr6:79577232 IRAK1BP1 0.35 7.86 0.3 1.6e-14 Endometrial cancer; BRCA cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg06697600 chr4:7070879 GRPEL1 -0.53 -10.77 -0.39 5.68e-25 Monocyte percentage of white cells; BRCA cis rs1997103 1.000 rs2177803 chr7:55410773 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg11266682 chr4:10021025 SLC2A9 0.48 12.8 0.45 1.51e-33 Bone mineral density; BRCA cis rs12681288 0.550 rs12549204 chr8:959085 G/T cg04851639 chr8:1020857 NA -0.3 -8.35 -0.31 4.29e-16 Schizophrenia; BRCA cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03264133 chr6:25882463 NA -0.53 -10.84 -0.39 3.11e-25 Intelligence (multi-trait analysis); BRCA cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg18876405 chr7:65276391 NA -0.63 -15.61 -0.53 8.75e-47 Aortic root size; BRCA cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg10523679 chr1:76189770 ACADM -0.47 -9.19 -0.34 5.31e-19 Daytime sleep phenotypes; BRCA cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg18404041 chr3:52824283 ITIH1 0.47 14.53 0.5 1.53e-41 Bipolar disorder; BRCA cis rs6964587 0.839 rs62466809 chr7:91472801 A/G cg17063962 chr7:91808500 NA 0.51 11.59 0.42 2.56e-28 Breast cancer; BRCA cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg08213375 chr14:104286397 PPP1R13B 0.42 9.07 0.34 1.47e-18 Reticulocyte count; BRCA cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.52 0.35 3.47e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg21770322 chr7:97807741 LMTK2 0.45 11.74 0.42 5.91e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs10191773 0.522 rs6747639 chr2:112967458 C/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.61 8.06 0.3 3.77e-15 Yeast infection; BRCA cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs514406 0.929 rs515857 chr1:53336859 A/G cg24675658 chr1:53192096 ZYG11B -0.49 -10.3 -0.38 3.9699999999999997e-23 Monocyte count; BRCA cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg18225595 chr11:63971243 STIP1 -0.47 -11.32 -0.41 3.4e-27 Platelet count; BRCA cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.87 -0.4 2.22e-25 Personality dimensions; BRCA cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.36 -0.31 3.87e-16 Colorectal cancer; BRCA cis rs796364 0.806 rs77853713 chr2:201006880 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.7 -10.29 -0.38 4.53e-23 Schizophrenia; BRCA cis rs11105298 0.891 rs11105318 chr12:89926658 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.5 -7.92 -0.3 1.04e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg06552810 chr11:31128660 NA 0.39 8.71 0.33 2.63e-17 Red blood cell count; BRCA cis rs735860 0.572 rs186003 chr6:53185124 A/C cg10236188 chr6:53219634 NA 0.4 8.33 0.31 4.81e-16 Glaucoma; BRCA cis rs7975161 0.624 rs11111943 chr12:104632418 T/C cg25273343 chr12:104657179 TXNRD1 -0.6 -9.46 -0.35 5.94e-20 Toenail selenium levels; BRCA cis rs8072100 0.840 rs1912482 chr17:45454883 G/A cg25173405 chr17:45401733 C17orf57 -0.57 -12.24 -0.44 4.19e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg11764359 chr7:65958608 NA -0.68 -15.38 -0.52 1.14e-45 Aortic root size; BRCA cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg00376283 chr12:123451042 ABCB9 0.56 14.55 0.5 1.17e-41 Platelet count; BRCA cis rs73086581 1.000 rs113812453 chr20:3963193 T/C cg02187196 chr20:3869020 PANK2 0.54 9.56 0.35 2.59e-20 Response to antidepressants in depression; BRCA cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.04e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg15704280 chr7:45808275 SEPT13 -0.78 -17.48 -0.57 3.23e-56 Coronary artery disease; BRCA cis rs9790314 0.715 rs980976 chr3:160771668 T/G cg04691961 chr3:161091175 C3orf57 -0.42 -8.78 -0.33 1.5e-17 Morning vs. evening chronotype; BRCA cis rs4285028 0.747 rs4048699 chr3:121404483 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.83 15.89 0.53 3.73e-48 Multiple sclerosis; BRCA cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg06671706 chr8:8559999 CLDN23 0.45 8.64 0.32 4.48e-17 Obesity-related traits; BRCA cis rs4566357 0.615 rs2396445 chr2:227917726 C/G cg11843606 chr2:227700838 RHBDD1 -0.45 -9.87 -0.36 1.83e-21 Coronary artery disease; BRCA cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg11366901 chr6:160182831 ACAT2 0.77 14.83 0.51 5.47e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs6785206 0.772 rs6439134 chr3:128323504 C/T cg16766828 chr3:128327626 NA -0.81 -11.71 -0.42 7.78e-29 Lymphocyte percentage of white cells; BRCA cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -8.11 -0.31 2.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2710642 0.566 rs2710651 chr2:63166379 G/A cg17519650 chr2:63277830 OTX1 0.42 9.84 0.36 2.25e-21 LDL cholesterol levels;LDL cholesterol; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg18765753 chr7:1198926 ZFAND2A -0.45 -10.51 -0.38 6.06e-24 Longevity;Endometriosis; BRCA cis rs78456975 0.739 rs13405352 chr2:1518726 C/T cg26248373 chr2:1572462 NA -0.53 -10.85 -0.39 2.73e-25 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg16423285 chr20:60520624 NA 0.63 13.24 0.46 1.48e-35 Obesity-related traits; BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.04 -0.3 4.34e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs514406 0.708 rs514881 chr1:53336737 A/G cg24675658 chr1:53192096 ZYG11B 0.66 14.87 0.51 3.46e-43 Monocyte count; BRCA cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg20503657 chr10:835505 NA 0.88 16.0 0.53 1.06e-48 Eosinophil percentage of granulocytes; BRCA cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg18132916 chr6:79620363 NA -0.49 -11.12 -0.4 2.26e-26 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg06238570 chr21:40685208 BRWD1 -0.4 -8.18 -0.31 1.55e-15 Menarche (age at onset); BRCA cis rs2836950 0.545 rs11700813 chr21:40517469 T/G cg17971929 chr21:40555470 PSMG1 -0.47 -10.18 -0.37 1.19e-22 Menarche (age at onset); BRCA cis rs3820928 0.874 rs1949807 chr2:227891861 A/G cg11843606 chr2:227700838 RHBDD1 -0.36 -8.21 -0.31 1.24e-15 Pulmonary function; BRCA cis rs7666738 0.515 rs13131874 chr4:98779183 A/G cg05340658 chr4:99064831 C4orf37 0.56 10.8 0.39 4.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs600231 0.542 rs12360896 chr11:65238306 G/T cg01292856 chr11:65242576 NA 0.66 14.96 0.51 1.27e-43 Bone mineral density; BRCA cis rs9457247 0.663 rs6456143 chr6:167415440 C/A cg07741184 chr6:167504864 NA 0.27 7.98 0.3 7.04e-15 Crohn's disease; BRCA cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg00166722 chr3:10149974 C3orf24 0.58 8.65 0.32 4.08e-17 Alzheimer's disease; BRCA cis rs3772130 0.886 rs9825248 chr3:121568711 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.68 0.39 1.33e-24 Cognitive performance; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00149659 chr3:10157352 C3orf10 0.71 12.5 0.44 3.07e-32 Alzheimer's disease; BRCA cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg03146154 chr1:46216737 IPP -0.45 -9.49 -0.35 4.35e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.16 -0.46 3.75e-35 Lymphocyte counts; BRCA cis rs2425143 1.000 rs7273174 chr20:34350306 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.09 -0.34 1.23e-18 Blood protein levels; BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26314531 chr2:26401878 FAM59B -0.97 -16.88 -0.56 3.96e-53 Gut microbiome composition (summer); BRCA cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10416265 0.528 rs3826906 chr19:33620897 C/T cg17764715 chr19:33622953 WDR88 0.51 8.15 0.31 1.86e-15 Bone properties (heel); BRCA cis rs4808199 0.895 rs6511036 chr19:19582651 A/G cg03709012 chr19:19516395 GATAD2A 1.08 20.66 0.63 4.98e-73 Nonalcoholic fatty liver disease; BRCA cis rs1029738 0.659 rs1608553 chr7:22896231 G/C cg06980547 chr7:22894557 NA -0.38 -8.09 -0.3 3.05e-15 Fibrinogen levels; BRCA cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg00701064 chr4:6280414 WFS1 0.64 16.21 0.54 8.82e-50 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs35110281 0.591 rs86139 chr21:44932802 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.43 8.98 0.33 3.11e-18 Mean corpuscular volume; BRCA cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.42 0.54 7.95e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs4930561 0.714 rs7130844 chr11:67927517 C/T cg04465784 chr11:67976953 SUV420H1 -0.27 -8.72 -0.33 2.4e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg12350822 chr6:88032061 C6orf162;GJB7 0.33 9.56 0.35 2.45e-20 Monocyte percentage of white cells; BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg19010396 chr19:19431384 KIAA0892;SF4 -0.45 -8.89 -0.33 6.39e-18 Tonsillectomy; BRCA cis rs11958404 0.858 rs72818142 chr5:157474934 C/T cg05962755 chr5:157440814 NA 0.54 9.55 0.35 2.72e-20 IgG glycosylation; BRCA cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg18867708 chr6:26865862 GUSBL1 0.4 8.07 0.3 3.47e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7617773 0.780 rs36121690 chr3:48345511 C/T cg11946769 chr3:48343235 NME6 0.68 13.91 0.48 1.31e-38 Coronary artery disease; BRCA cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02018176 chr4:1364513 KIAA1530 0.39 8.2 0.31 1.37e-15 Longevity; BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg05863683 chr7:1912471 MAD1L1 0.39 7.98 0.3 6.83e-15 Bipolar disorder and schizophrenia; BRCA cis rs11249608 0.548 rs17078991 chr5:178459426 A/C cg21905437 chr5:178450457 ZNF879 0.51 10.65 0.39 1.75e-24 Pubertal anthropometrics; BRCA cis rs4853036 0.680 rs35413900 chr2:70113900 C/G cg02498382 chr2:70120550 SNRNP27 -0.59 -9.55 -0.35 2.75e-20 Colorectal or endometrial cancer; BRCA cis rs16976116 0.851 rs28889339 chr15:55503205 T/G cg11288833 chr15:55489084 RSL24D1 0.47 10.52 0.38 5.59e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9788682 0.747 rs2656072 chr15:78744292 A/G cg24631222 chr15:78858424 CHRNA5 -0.5 -9.95 -0.37 9.07e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs2549003 0.674 rs960757 chr5:131826310 G/A cg21138405 chr5:131827807 IRF1 0.38 11.46 0.41 8.9e-28 Asthma (sex interaction); BRCA cis rs2204008 0.776 rs8186824 chr12:38316537 A/C cg13010199 chr12:38710504 ALG10B 0.39 8.44 0.32 2.08e-16 Bladder cancer; BRCA cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg15556689 chr8:8085844 FLJ10661 -0.59 -16.86 -0.55 5.07e-53 Neuroticism; BRCA cis rs2625529 0.652 rs2957728 chr15:72236432 G/T cg16672083 chr15:72433130 SENP8 0.67 16.14 0.54 2.14e-49 Red blood cell count; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg15112475 chr7:1198522 ZFAND2A -0.56 -13.68 -0.48 1.48e-37 Longevity;Endometriosis; BRCA cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.06 0.3 3.64e-15 Asthma; BRCA cis rs9815354 0.812 rs4264702 chr3:41952539 T/A cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15506890 chr2:3487001 NA -0.57 -12.89 -0.45 5.88e-34 Neurofibrillary tangles; BRCA cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.77 -0.5 1.05e-42 Total cholesterol levels; BRCA cis rs950776 0.518 rs4243083 chr15:78833830 C/G cg06917634 chr15:78832804 PSMA4 -0.76 -17.8 -0.58 7.59e-58 Sudden cardiac arrest; BRCA cis rs910316 0.763 rs175057 chr14:75489632 C/T cg08847533 chr14:75593920 NEK9 -0.82 -19.05 -0.6 2.15e-64 Height; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.04 -0.4 4.63e-26 Lymphocyte counts; BRCA cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg19901468 chr14:105411992 AHNAK2 -0.51 -12.4 -0.44 8.92e-32 Rheumatoid arthritis; BRCA cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.97e-15 Breast cancer; BRCA trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg15556689 chr8:8085844 FLJ10661 -0.35 -9.19 -0.34 5.61e-19 Neuroticism; BRCA cis rs9560113 1.000 rs9560113 chr13:112183348 A/G cg10483660 chr13:112241077 NA 0.32 8.16 0.31 1.79e-15 Menarche (age at onset); BRCA cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg16325326 chr1:53192061 ZYG11B -0.7 -18.31 -0.59 1.56e-60 Monocyte count; BRCA cis rs7129727 1 rs7129727 chr11:57484660 G/A cg19752551 chr11:57585705 CTNND1 -0.42 -10.8 -0.39 4.38e-25 Autism spectrum disorder or schizophrenia; BRCA cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs244731 0.959 rs7721671 chr5:176630984 A/G cg17509989 chr5:176798049 RGS14 -0.74 -11.99 -0.43 5.26e-30 Urate levels in lean individuals; BRCA cis rs13053817 1.000 rs71329487 chr22:29833469 A/G cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.51 -9.6 -0.36 1.7e-20 Carotid atherosclerosis in HIV infection; BRCA cis rs11190604 0.767 rs4559620 chr10:102199935 C/T cg07080220 chr10:102295463 HIF1AN 0.49 10.31 0.38 3.54e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs595982 0.527 rs17272673 chr19:49362992 C/A cg15549821 chr19:49342101 PLEKHA4 -0.72 -11.38 -0.41 1.88e-27 Red cell distribution width; BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 13.75 0.48 7.09e-38 Alzheimer's disease; BRCA cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg14983838 chr19:29218262 NA 0.49 9.81 0.36 2.86e-21 Methadone dose in opioid dependence; BRCA cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg11764359 chr7:65958608 NA 0.64 11.52 0.41 5.18e-28 Aortic root size; BRCA cis rs6835098 0.923 rs7671278 chr4:174095769 A/G cg27433088 chr4:174089019 GALNT7 0.33 8.91 0.33 5.2e-18 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.57 10.2 0.37 9.38e-23 Lung cancer in ever smokers; BRCA cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg05234568 chr11:5960015 NA -0.49 -9.66 -0.36 1.04e-20 DNA methylation (variation); BRCA trans rs3808502 0.549 rs7831039 chr8:11427637 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -11.35 -0.41 2.5e-27 Neuroticism; BRCA cis rs2153535 0.541 rs4637688 chr6:8446501 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.01 0.34 2.36e-18 Motion sickness; BRCA cis rs2839186 0.934 rs4819221 chr21:47695417 G/T cg12379764 chr21:47803548 PCNT 0.37 8.06 0.3 3.78e-15 Testicular germ cell tumor; BRCA cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg04248312 chr19:17393744 ANKLE1 0.91 20.45 0.63 6.59e-72 Systemic lupus erythematosus; BRCA cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg06271696 chr7:157225062 NA -0.39 -10.35 -0.38 2.6e-23 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg12386194 chr3:101231763 SENP7 0.46 9.91 0.36 1.29e-21 Colorectal cancer; BRCA cis rs6901250 0.655 rs9384990 chr6:117126941 A/G cg12892004 chr6:117198278 RFX6 0.38 9.28 0.34 2.5e-19 C-reactive protein levels; BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg04944784 chr2:26401820 FAM59B -0.96 -16.37 -0.54 1.41e-50 Gut microbiome composition (summer); BRCA cis rs7246657 0.882 rs4803539 chr19:37897522 A/C cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.46e-20 Coronary artery calcification; BRCA cis rs7267979 1.000 rs447722 chr20:25443510 C/T cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6450176 0.909 rs10940353 chr5:53299959 A/C ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.52 -0.5 1.65e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs61931739 0.500 rs12367292 chr12:33998075 T/C cg13010199 chr12:38710504 ALG10B 0.47 8.99 0.34 2.82e-18 Morning vs. evening chronotype; BRCA cis rs36051895 0.659 rs10815150 chr9:5067301 C/A cg02405213 chr9:5042618 JAK2 -0.49 -9.43 -0.35 7.63e-20 Pediatric autoimmune diseases; BRCA cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.3 -0.38 4e-23 Reticulocyte count; BRCA cis rs6964587 0.605 rs6956022 chr7:91553199 A/G cg17063962 chr7:91808500 NA -0.56 -12.82 -0.45 1.23e-33 Breast cancer; BRCA trans rs7819412 0.691 rs73198970 chr8:11040216 T/C cg06636001 chr8:8085503 FLJ10661 -0.43 -8.67 -0.32 3.65e-17 Triglycerides; BRCA cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg03929089 chr4:120376271 NA 0.56 9.69 0.36 8.39e-21 Acute lymphoblastic leukemia (childhood); BRCA cis rs11051970 0.879 rs950079 chr12:32588620 A/G cg24626660 chr12:32551988 NA 0.29 8.36 0.31 4e-16 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs7819412 0.502 rs4841499 chr8:10988138 A/C cg15556689 chr8:8085844 FLJ10661 -0.36 -8.37 -0.31 3.68e-16 Triglycerides; BRCA cis rs2964802 0.505 rs7729989 chr5:10822246 A/G cg14521931 chr5:10832172 NA -0.58 -12.68 -0.45 5.14e-33 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg06713675 chr4:122721982 EXOSC9 -0.53 -12.07 -0.43 2.42e-30 Type 2 diabetes; BRCA cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg03676636 chr4:99064102 C4orf37 0.23 8.26 0.31 8.09e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg09060608 chr5:178986726 RUFY1 0.61 15.62 0.53 8.06e-47 Lung cancer; BRCA cis rs7312933 0.703 rs11181380 chr12:42616040 A/T cg01256987 chr12:42539512 GXYLT1 -0.47 -9.24 -0.34 3.68e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs8058578 0.943 rs35629860 chr16:30671532 G/A cg00531865 chr16:30841666 NA -0.5 -10.99 -0.4 7.23e-26 Multiple myeloma; BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg04267008 chr7:1944627 MAD1L1 -0.46 -9.79 -0.36 3.56e-21 Schizophrenia; BRCA cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg23788917 chr6:8435910 SLC35B3 0.49 10.55 0.39 4.36e-24 Motion sickness; BRCA cis rs1448094 0.512 rs7970081 chr12:86243392 G/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.31 -0.35 2.09e-19 Major depressive disorder; BRCA cis rs9467773 0.595 rs13207371 chr6:26591074 G/A cg11502198 chr6:26597334 ABT1 0.48 9.57 0.35 2.28e-20 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg11663144 chr21:46675770 NA -0.55 -12.98 -0.46 2.41e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2230307 0.536 rs554742 chr1:100512568 G/A cg24955406 chr1:100503596 HIAT1 0.53 10.09 0.37 2.55e-22 Carotid intima media thickness; BRCA cis rs2624839 0.602 rs2526390 chr3:50192760 C/T cg05623727 chr3:50126028 RBM5 0.43 8.97 0.33 3.23e-18 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -11.1 -0.4 2.77e-26 Glomerular filtration rate (creatinine); BRCA cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.5 0.44 3.29e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2742234 0.590 rs1254960 chr10:43699657 C/T cg15436174 chr10:43711423 RASGEF1A 0.57 11.53 0.41 4.62e-28 Hirschsprung disease; BRCA cis rs9381107 1.000 rs9381212 chr6:9476532 C/T cg14735645 chr6:9486422 NA -0.45 -8.01 -0.3 5.47e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg01877450 chr7:97915802 BRI3 -0.37 -8.33 -0.31 4.82e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.86 0.39 2.42e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg12219531 chr12:120966889 COQ5 0.53 11.33 0.41 2.99e-27 High light scatter reticulocyte count; BRCA cis rs7945718 0.967 rs7931147 chr11:12748884 C/A cg25843174 chr11:12811716 TEAD1 0.21 8.02 0.3 4.91e-15 Educational attainment (years of education); BRCA cis rs2073300 0.609 rs2295238 chr20:23387946 C/G cg12062639 chr20:23401060 NAPB 0.89 12.67 0.45 5.41e-33 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs877282 0.945 rs11253397 chr10:789774 A/G cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs6545883 0.894 rs2600660 chr2:61549600 G/T cg15711740 chr2:61764176 XPO1 0.5 12.15 0.43 1.1e-30 Tuberculosis; BRCA trans rs9325144 0.555 rs4882359 chr12:38726679 T/C cg23762105 chr12:34175262 ALG10 -0.38 -9.72 -0.36 6.49e-21 Morning vs. evening chronotype; BRCA cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg02389323 chr16:88786976 FAM38A -0.61 -10.68 -0.39 1.28e-24 Plateletcrit; BRCA cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg16339924 chr4:17578868 LAP3 0.64 16.18 0.54 1.37e-49 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg03517284 chr6:25882590 NA -0.45 -9.31 -0.35 2.09e-19 Intelligence (multi-trait analysis); BRCA cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.39 8.33 0.31 4.96e-16 Osteoporosis; BRCA cis rs11105298 0.891 rs10858872 chr12:89872932 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.94 -0.37 9.36e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg11062466 chr8:58055876 NA 0.49 8.53 0.32 1.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg09263875 chr16:632152 PIGQ 0.73 21.35 0.65 9.35e-77 Height; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.6 -11.64 -0.42 1.54e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7246657 0.722 rs3829688 chr19:38077100 T/C cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs7572733 0.555 rs2342558 chr2:198920142 T/C cg00792783 chr2:198669748 PLCL1 0.39 8.75 0.33 1.94e-17 Dermatomyositis; BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg10729496 chr3:10149963 C3orf24 0.49 9.27 0.34 2.92e-19 Alzheimer's disease; BRCA cis rs1153858 1.000 rs3809472 chr15:45694318 G/T cg21132104 chr15:45694354 SPATA5L1 0.75 16.48 0.55 4.24e-51 Homoarginine levels; BRCA cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.92 -0.37 1.1e-21 Alzheimer's disease (late onset); BRCA cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg14963724 chr18:72166303 CNDP2 -0.34 -9.53 -0.35 3.34e-20 Refractive error; BRCA cis rs6964587 0.692 rs17672805 chr7:91573466 A/G cg17063962 chr7:91808500 NA -0.55 -12.54 -0.44 2.02e-32 Breast cancer; BRCA cis rs27434 0.583 rs149431 chr5:96157541 T/C cg16492584 chr5:96139282 ERAP1 -0.5 -12.76 -0.45 2.31e-33 Ankylosing spondylitis; BRCA cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg12564285 chr5:131593104 PDLIM4 0.32 7.98 0.3 6.58e-15 Blood metabolite levels; BRCA cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -8.93 -0.33 4.43e-18 Bipolar disorder; BRCA cis rs10028773 0.700 rs7671797 chr4:120248157 A/G cg09307838 chr4:120376055 NA 0.63 13.53 0.47 7.67e-37 Educational attainment; BRCA cis rs698833 0.859 rs1302175 chr2:44657024 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.9 0.36 1.36e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -9.11 -0.34 1.06e-18 Alzheimer's disease; BRCA cis rs501916 0.604 rs616871 chr15:48058259 T/A cg16110827 chr15:48056943 SEMA6D -0.42 -9.2 -0.34 5.1e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA trans rs8073060 0.586 rs225265 chr17:33961972 C/T cg19694781 chr19:47549865 TMEM160 -1.05 -21.13 -0.64 1.41e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs4481887 0.800 rs4514268 chr1:248444600 T/G cg00666640 chr1:248458726 OR2T12 0.32 8.92 0.33 5.05e-18 Common traits (Other); BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg27170947 chr2:26402098 FAM59B 0.65 11.43 0.41 1.22e-27 Gut microbiome composition (summer); BRCA trans rs4332037 0.805 rs10278591 chr7:1921362 A/G cg11693508 chr17:37793320 STARD3 -0.43 -8.89 -0.33 6.1e-18 Bipolar disorder; BRCA cis rs13064411 0.696 rs6769516 chr3:113219905 T/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 19.54 0.61 4.85e-67 Platelet count; BRCA cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.54 10.19 0.37 1.03e-22 Aortic root size; BRCA cis rs6912958 0.781 rs9450732 chr6:88249826 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.82e-16 Monocyte percentage of white cells; BRCA cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.79 0.6 5.12e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs2727020 0.894 rs2866361 chr11:49372481 A/G cg03929089 chr4:120376271 NA -0.69 -13.76 -0.48 6.25e-38 Coronary artery disease; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg09060608 chr5:178986726 RUFY1 0.47 11.24 0.41 7.32e-27 Lung cancer; BRCA cis rs1865760 0.929 rs12195653 chr6:25958621 A/G cg17691542 chr6:26056736 HIST1H1C 0.49 10.08 0.37 2.84e-22 Height; BRCA cis rs868036 0.645 rs4776987 chr15:68123915 A/T cg24579218 chr15:68104479 NA 0.37 8.12 0.31 2.5e-15 Restless legs syndrome; BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg21747090 chr2:27597821 SNX17 -0.37 -7.89 -0.3 1.33e-14 Total body bone mineral density; BRCA cis rs4363385 0.791 rs372490 chr1:153008971 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.94 -0.51 1.6e-43 Total cholesterol levels; BRCA cis rs274567 0.550 rs272885 chr5:131667736 A/G cg11843238 chr5:131593191 PDLIM4 0.36 8.01 0.3 5.43e-15 Blood metabolite levels; BRCA cis rs4268898 0.722 rs4665253 chr2:24382546 G/A cg26838691 chr2:24397539 C2orf84 0.41 8.26 0.31 8.66e-16 Asthma; BRCA cis rs1348850 0.914 rs3902850 chr2:178315899 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 10.01 0.37 5.21e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4780401 0.573 rs8045673 chr16:11804385 C/A cg01061890 chr16:11836724 TXNDC11 -0.54 -12.29 -0.44 2.51e-31 Rheumatoid arthritis; BRCA cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg18225595 chr11:63971243 STIP1 0.6 15.04 0.51 5.18e-44 Platelet count; BRCA cis rs10501293 1.000 rs7111028 chr11:43060516 C/T cg03447554 chr11:43094025 NA 0.5 9.15 0.34 7.78e-19 Cognitive performance; BRCA cis rs367943 0.965 rs458044 chr5:112797779 A/G cg12552261 chr5:112820674 MCC -0.55 -12.11 -0.43 1.5e-30 Type 2 diabetes; BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg14004847 chr7:1930337 MAD1L1 -0.46 -8.77 -0.33 1.65e-17 Bipolar disorder and schizophrenia; BRCA cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg01579765 chr21:45077557 HSF2BP -0.42 -11.64 -0.42 1.55e-28 Mean corpuscular volume; BRCA cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg14963724 chr18:72166303 CNDP2 -0.33 -9.1 -0.34 1.16e-18 Refractive error; BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg26314531 chr2:26401878 FAM59B -0.9 -16.15 -0.54 1.92e-49 Gut microbiome composition (summer); BRCA cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg13010199 chr12:38710504 ALG10B 0.44 8.8 0.33 1.24e-17 Morning vs. evening chronotype; BRCA cis rs870825 0.929 rs55880126 chr4:185591237 T/G cg20176042 chr4:185552304 CASP3 -0.62 -8.51 -0.32 1.27e-16 Blood protein levels; BRCA cis rs11191270 0.784 rs11191264 chr10:104096732 A/T cg15320455 chr10:103880129 LDB1 0.49 8.0 0.3 5.96e-15 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.619 rs9567289 chr13:44437104 C/T cg12856521 chr11:46389249 DGKZ 0.37 8.14 0.31 2.09e-15 Leprosy; BRCA cis rs586533 0.846 rs644737 chr11:99502337 G/C cg22878054 chr11:99397252 CNTN5 0.32 8.06 0.3 3.65e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9473147 0.516 rs9381579 chr6:47556680 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.62 0.36 1.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.46 0.77 1.4e-126 Chronic sinus infection; BRCA cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg14829155 chr15:31115871 NA -0.43 -10.05 -0.37 3.67e-22 Huntington's disease progression; BRCA cis rs10504229 0.610 rs6993531 chr8:58147283 A/G cg24829409 chr8:58192753 C8orf71 -0.43 -8.55 -0.32 9.12e-17 Developmental language disorder (linguistic errors); BRCA cis rs67478160 0.643 rs12880821 chr14:104276049 C/T cg08213375 chr14:104286397 PPP1R13B 0.61 16.2 0.54 1.06e-49 Schizophrenia; BRCA cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -10.28 -0.38 4.7e-23 Schizophrenia; BRCA cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg02820040 chr2:241836501 C2orf54 -0.51 -9.79 -0.36 3.56e-21 Urinary metabolites; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg25036284 chr2:26402008 FAM59B -0.91 -15.44 -0.52 6.18e-46 Gut microbiome composition (summer); BRCA cis rs77972916 0.536 rs6751209 chr2:43588302 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.6 -10.8 -0.39 4.49e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs7246657 0.943 rs12709813 chr19:37844983 G/A cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.1 0.34 1.13e-18 Tonsillectomy; BRCA trans rs208520 0.955 rs9345808 chr6:67008262 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.7 11.81 0.42 2.92e-29 Exhaled nitric oxide output; BRCA cis rs9807989 0.507 rs1420105 chr2:103035119 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.28e-16 Asthma; BRCA cis rs35146811 0.700 rs7788301 chr7:99782753 C/G cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs3768617 0.510 rs2296293 chr1:183095477 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs9325144 0.560 rs7980358 chr12:38640396 C/G cg26384229 chr12:38710491 ALG10B 0.55 13.73 0.48 8.81e-38 Morning vs. evening chronotype; BRCA cis rs4908768 0.539 rs1061039 chr1:8642588 T/C cg20416874 chr1:8611966 RERE -0.27 -7.87 -0.3 1.51e-14 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg22676075 chr6:135203613 NA 0.43 8.51 0.32 1.21e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg12310025 chr6:25882481 NA 0.41 9.36 0.35 1.34e-19 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.887 rs9358870 chr6:25719210 T/C cg17691542 chr6:26056736 HIST1H1C 0.64 11.23 0.41 7.48e-27 Iron status biomarkers; BRCA cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11644478 chr21:40555479 PSMG1 0.83 19.17 0.6 4.6e-65 Cognitive function; BRCA cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg03806693 chr22:41940476 POLR3H -1.11 -21.97 -0.66 3.88e-80 Vitiligo; BRCA cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.8 -0.36 3.28e-21 Alzheimer's disease (late onset); BRCA cis rs17270561 0.636 rs1575535 chr6:25809909 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 9.51 0.35 3.93e-20 Iron status biomarkers; BRCA cis rs877282 0.898 rs11253338 chr10:759559 C/T cg17470449 chr10:769945 NA 0.47 7.99 0.3 6.3e-15 Uric acid levels; BRCA cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs68170813 0.559 rs6967638 chr7:106929356 T/G cg02696742 chr7:106810147 HBP1 -0.54 -8.66 -0.32 3.83e-17 Coronary artery disease; BRCA cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg25809561 chr17:30822961 MYO1D -0.38 -9.26 -0.34 2.98e-19 Schizophrenia; BRCA cis rs6964587 0.967 rs41371748 chr7:91708219 A/G cg17063962 chr7:91808500 NA 0.56 11.76 0.42 4.86e-29 Breast cancer; BRCA cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg13010199 chr12:38710504 ALG10B -0.36 -8.59 -0.32 6.9e-17 Morning vs. evening chronotype; BRCA cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg25174290 chr11:3078921 CARS -0.3 -7.85 -0.3 1.72e-14 Calcium levels; BRCA cis rs7617773 0.780 rs4511916 chr3:48350366 G/A cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg26384229 chr12:38710491 ALG10B -0.63 -15.16 -0.51 1.43e-44 Drug-induced liver injury (flucloxacillin); BRCA cis rs1865760 0.593 rs9393676 chr6:25936944 G/A cg03264133 chr6:25882463 NA -0.37 -8.1 -0.31 2.85e-15 Height; BRCA cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg06238570 chr21:40685208 BRWD1 -0.47 -9.31 -0.35 1.97e-19 Cognitive function; BRCA cis rs796364 0.906 rs281784 chr2:200749749 T/A cg23649088 chr2:200775458 C2orf69 0.6 8.92 0.33 4.8e-18 Schizophrenia; BRCA cis rs2011503 0.882 rs72999053 chr19:19375372 G/A cg11584989 chr19:19387371 SF4 0.66 14.59 0.5 8.19e-42 Bipolar disorder; BRCA cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg13902645 chr11:5959945 NA -0.49 -10.01 -0.37 5.17e-22 DNA methylation (variation); BRCA cis rs3784262 0.631 rs6493980 chr15:58352290 A/G cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.23 -0.38 7.54e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs3125734 0.660 rs4979780 chr10:63992740 A/C cg19640130 chr10:64028056 RTKN2 -0.29 -8.24 -0.31 9.67e-16 Rheumatoid arthritis; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7715811 0.913 rs10513154 chr5:13780601 T/C cg07548982 chr5:13769939 DNAH5 -0.4 -8.74 -0.33 2.08e-17 Subclinical atherosclerosis traits (other); BRCA cis rs10752881 0.967 rs10911186 chr1:182972542 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.89 0.56 3.56e-53 Colorectal cancer; BRCA cis rs11971779 0.793 rs11772447 chr7:139033589 T/G cg07862535 chr7:139043722 LUC7L2 0.44 11.63 0.42 1.73e-28 Diisocyanate-induced asthma; BRCA cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg25358565 chr5:93447407 FAM172A 1.18 17.78 0.58 9.73e-58 Diabetic retinopathy; BRCA cis rs12760731 0.565 rs35926996 chr1:178075351 A/G cg00404053 chr1:178313656 RASAL2 0.66 8.05 0.3 4.02e-15 Obesity-related traits; BRCA cis rs7582180 0.629 rs11686799 chr2:100956055 C/G cg14675211 chr2:100938903 LONRF2 0.52 11.77 0.42 4.22e-29 Intelligence (multi-trait analysis); BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg07343612 chr16:622815 PIGQ -0.68 -22.12 -0.66 6.49e-81 Height; BRCA cis rs2797160 0.967 rs8180614 chr6:126000599 G/C cg05901451 chr6:126070800 HEY2 -0.39 -9.41 -0.35 9.06e-20 Endometrial cancer; BRCA cis rs12579753 0.871 rs10862363 chr12:82201254 T/A cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.16 -0.31 1.74e-15 Total body bone mineral density; BRCA cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg06046430 chr4:77819534 ANKRD56 0.61 13.63 0.47 2.57e-37 Emphysema distribution in smoking; BRCA cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.93e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9649465 0.967 rs1008539 chr7:123305518 G/A cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.66e-16 Migraine; BRCA cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.67 -0.36 9.82e-21 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.664 rs2274649 chr9:5090934 A/T cg02405213 chr9:5042618 JAK2 -0.5 -8.91 -0.33 5.35e-18 Pediatric autoimmune diseases; BRCA cis rs4466137 0.868 rs4703962 chr5:82999808 A/G cg16102102 chr5:83017553 HAPLN1 -0.9 -18.33 -0.59 1.26e-60 Prostate cancer; BRCA cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg04455712 chr21:45112962 RRP1B 0.39 10.01 0.37 5.14e-22 Mean corpuscular volume; BRCA cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg22972055 chr7:872293 UNC84A 0.38 8.51 0.32 1.24e-16 Cerebrospinal P-tau181p levels; BRCA cis rs858239 0.568 rs6970694 chr7:23250828 T/C cg23682824 chr7:23144976 KLHL7 0.34 8.56 0.32 8.41e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs7254827 1.000 rs4808566 chr19:17214051 T/G cg19418318 chr19:17219073 MYO9B -0.49 -10.25 -0.38 6.25e-23 Mean platelet volume; BRCA cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.94 -0.33 4.23e-18 Alzheimer's disease (late onset); BRCA trans rs7829975 0.593 rs2979241 chr8:8303353 G/C cg21775007 chr8:11205619 TDH 0.39 8.04 0.3 4.41e-15 Mood instability; BRCA cis rs7177699 0.557 rs7403728 chr15:79112016 T/G cg00540400 chr15:79124168 NA -0.28 -7.81 -0.3 2.4e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs3008870 0.583 rs17497947 chr1:67457199 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.89 -16.53 -0.55 2.17e-51 Lymphocyte percentage of white cells; BRCA cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg10518543 chr12:38710700 ALG10B 0.36 7.97 0.3 7.37e-15 Morning vs. evening chronotype; BRCA cis rs4237845 0.636 rs11172371 chr12:58286188 C/T cg00677455 chr12:58241039 CTDSP2 0.67 15.08 0.51 3.6e-44 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.68e-24 Motion sickness; BRCA cis rs9815354 0.812 rs61661916 chr3:41921915 T/C cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs1801251 1.000 rs4973054 chr2:233710713 G/C cg25237894 chr2:233734115 C2orf82 -0.4 -11.34 -0.41 2.66e-27 Coronary artery disease; BRCA cis rs7945718 0.839 rs763373 chr11:12840342 C/G cg25843174 chr11:12811716 TEAD1 -0.21 -8.1 -0.3 2.9e-15 Educational attainment (years of education); BRCA trans rs1997103 1.000 rs1997102 chr7:55399322 A/C cg20935933 chr6:143382018 AIG1 -0.61 -11.42 -0.41 1.31e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7917772 0.636 rs4418737 chr10:104525123 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.58 -0.39 3.11e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs765787 0.530 rs11854294 chr15:45527996 A/G cg24006582 chr15:45444508 DUOX1 -0.53 -10.98 -0.4 7.9e-26 Uric acid levels; BRCA cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg13175981 chr1:150552382 MCL1 0.42 9.4 0.35 9.26e-20 Tonsillectomy; BRCA cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg25427524 chr10:38739819 LOC399744 -0.61 -13.9 -0.48 1.45e-38 Extrinsic epigenetic age acceleration; BRCA cis rs9291683 0.595 rs13145442 chr4:10037261 C/A cg02734326 chr4:10020555 SLC2A9 0.39 8.48 0.32 1.59e-16 Bone mineral density; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg08805041 chr16:621841 PIGQ -0.32 -8.52 -0.32 1.14e-16 Height; BRCA cis rs12545109 0.800 rs2670026 chr8:57424338 G/T cg09654669 chr8:57350985 NA -0.38 -8.35 -0.31 4.27e-16 Obesity-related traits; BRCA trans rs11098499 0.754 rs12513083 chr4:120249612 A/T cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.38e-23 Corneal astigmatism; BRCA cis rs9790314 1.000 rs975323 chr3:161021322 A/G cg03342759 chr3:160939853 NMD3 -0.64 -13.47 -0.47 1.36e-36 Morning vs. evening chronotype; BRCA cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg00012203 chr2:219082015 ARPC2 0.69 15.41 0.52 8.8e-46 Colorectal cancer; BRCA cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg05623727 chr3:50126028 RBM5 0.43 10.11 0.37 2.24e-22 Intelligence (multi-trait analysis); BRCA cis rs7552167 1.000 rs59960858 chr1:24519437 C/A cg01960748 chr1:24522592 NA 0.63 10.48 0.38 8.28e-24 Psoriasis vulgaris; BRCA cis rs9287719 0.746 rs6742448 chr2:10759126 G/A cg00105475 chr2:10696890 NA 0.42 9.61 0.36 1.65e-20 Prostate cancer; BRCA cis rs2243480 1.000 rs1267820 chr7:66050295 C/G cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.29e-47 Diabetic kidney disease; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg07308232 chr7:1071921 C7orf50 -0.36 -7.9 -0.3 1.26e-14 Longevity;Endometriosis; BRCA cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg26408565 chr15:76604113 ETFA -0.48 -10.32 -0.38 3.37e-23 Blood metabolite levels; BRCA trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg16141378 chr3:129829833 LOC729375 0.32 7.9 0.3 1.19e-14 Neuroticism; BRCA cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.57 0.52 1.4e-46 Colorectal cancer; BRCA trans rs9409565 0.826 rs9409556 chr9:97239268 T/C cg05679027 chr9:99775184 HIATL2 -0.43 -9.42 -0.35 8.31e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs6714710 0.603 rs35505530 chr2:98506910 T/C cg26665480 chr2:98280029 ACTR1B 0.58 13.47 0.47 1.4e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg25214090 chr10:38739885 LOC399744 0.57 12.97 0.46 2.58e-34 Corneal astigmatism; BRCA cis rs9287719 0.967 rs6432116 chr2:10748615 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs7818345 0.967 rs12543061 chr8:19286181 G/T cg11303988 chr8:19266685 CSGALNACT1 -0.31 -8.23 -0.31 1.01e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg05347473 chr6:146136440 FBXO30 -0.42 -8.36 -0.31 3.91e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs11229555 0.645 rs61903159 chr11:58184475 G/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs72781680 0.611 rs55788848 chr2:24268721 C/T cg06627628 chr2:24431161 ITSN2 -0.54 -8.81 -0.33 1.15e-17 Lymphocyte counts; BRCA cis rs9790314 0.747 rs7619011 chr3:160855676 A/G cg04691961 chr3:161091175 C3orf57 -0.37 -8.01 -0.3 5.29e-15 Morning vs. evening chronotype; BRCA cis rs13046373 0.535 rs1605428 chr21:32028976 T/C cg16812893 chr21:31813075 KRTAP15-1 0.38 9.18 0.34 5.98e-19 HDL cholesterol; BRCA cis rs6450176 1.000 rs4588541 chr5:53300640 A/G ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.14 -0.51 1.8e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg22920501 chr2:26401640 FAM59B -0.67 -11.5 -0.41 5.96e-28 Gut microbiome composition (summer); BRCA cis rs6456156 0.565 rs6456153 chr6:167472167 T/C cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs490234 0.783 rs13284243 chr9:128381785 A/G cg14078157 chr9:128172775 NA -0.46 -10.58 -0.39 3.23e-24 Mean arterial pressure; BRCA cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.49 -8.72 -0.33 2.4e-17 Schizophrenia; BRCA cis rs6740322 0.895 rs13384080 chr2:43557363 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.11 -0.43 1.53e-30 Coronary artery disease; BRCA cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg12927641 chr6:109611667 NA -0.37 -9.15 -0.34 7.79e-19 Reticulocyte fraction of red cells; BRCA cis rs2276314 0.802 rs4799838 chr18:33597530 T/C cg05985134 chr18:33552581 C18orf21 0.64 11.51 0.41 5.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs7824557 0.778 rs6601572 chr8:11093337 C/G cg06636001 chr8:8085503 FLJ10661 -0.46 -9.06 -0.34 1.56e-18 Retinal vascular caliber; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg04518342 chr5:131593106 PDLIM4 -0.37 -9.22 -0.34 4.32e-19 Breast cancer; BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg14004847 chr7:1930337 MAD1L1 -0.47 -9.94 -0.37 9.49e-22 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 3.92e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg11266682 chr4:10021025 SLC2A9 0.44 11.28 0.41 5.03e-27 Bone mineral density; BRCA cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg12826209 chr6:26865740 GUSBL1 0.72 12.83 0.45 1.08e-33 Intelligence (multi-trait analysis); BRCA cis rs4722166 0.598 rs4722180 chr7:22805072 A/G cg05472934 chr7:22766657 IL6 0.4 9.87 0.36 1.69e-21 Lung cancer; BRCA cis rs7617773 0.780 rs3731489 chr3:48228906 C/A cg11946769 chr3:48343235 NME6 0.67 13.95 0.48 8.71e-39 Coronary artery disease; BRCA cis rs503734 0.504 rs348873 chr3:100930665 C/T cg27318481 chr3:100970896 IMPG2 -0.37 -8.84 -0.33 9.1e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg14847009 chr1:175162515 KIAA0040 0.25 9.67 0.36 1.01e-20 Alcohol dependence; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.68 -0.32 3.22e-17 Total body bone mineral density; BRCA cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg23711669 chr6:146136114 FBXO30 0.77 17.81 0.58 6.21e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg01877450 chr7:97915802 BRI3 -0.39 -8.98 -0.33 3.1e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg18404041 chr3:52824283 ITIH1 -0.35 -9.13 -0.34 8.95e-19 Schizophrenia; BRCA cis rs11893307 0.599 rs11900857 chr2:191659011 T/C cg05765582 chr2:191677683 NA 0.44 8.08 0.3 3.34e-15 Mean platelet volume; BRCA cis rs6598955 0.671 rs17163749 chr1:26568165 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.85 0.33 8.36e-18 Obesity-related traits; BRCA cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg18230493 chr5:56204884 C5orf35 -0.69 -13.43 -0.47 2.18e-36 Initial pursuit acceleration; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 21.9 0.65 9.33e-80 Platelet count; BRCA cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg06636001 chr8:8085503 FLJ10661 0.59 13.58 0.47 4.44e-37 Mood instability; BRCA cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs4808199 0.948 rs11085261 chr19:19462606 G/A cg01262667 chr19:19385393 TM6SF2 0.38 8.18 0.31 1.52e-15 Nonalcoholic fatty liver disease; BRCA cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.52 0.44 2.49e-32 Electroencephalogram traits; BRCA cis rs875971 1.000 rs4717300 chr7:65947380 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs3762637 1.000 rs28434553 chr3:122229515 C/A cg24169773 chr3:122142474 KPNA1 -0.43 -8.03 -0.3 4.75e-15 LDL cholesterol levels; BRCA cis rs7927771 0.524 rs11039419 chr11:47851354 C/T cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Subjective well-being; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg01877450 chr7:97915802 BRI3 -0.37 -8.6 -0.32 6.32e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 3.95e-25 Bipolar disorder; BRCA cis rs870825 0.616 rs4256263 chr4:185622959 C/A cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg24549020 chr5:56110836 MAP3K1 0.41 8.66 0.32 3.76e-17 Initial pursuit acceleration; BRCA cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg10523679 chr1:76189770 ACADM 0.76 16.11 0.54 2.87e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs78487399 0.908 rs73925552 chr2:43810564 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -7.89 -0.3 1.33e-14 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs782590 0.774 rs782632 chr2:55898290 C/G cg18811423 chr2:55921094 PNPT1 0.78 26.77 0.73 1.8e-106 Metabolic syndrome; BRCA cis rs9311474 0.659 rs7638808 chr3:52572056 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.35 -12.1 -0.43 1.72e-30 Electroencephalogram traits; BRCA cis rs832540 0.966 rs252923 chr5:56205662 T/G cg24531977 chr5:56204891 C5orf35 -0.44 -9.25 -0.34 3.45e-19 Coronary artery disease; BRCA cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 8.1 0.3 2.89e-15 Diabetic retinopathy; BRCA cis rs7246657 0.943 rs10406177 chr19:37907947 G/A cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs877529 0.967 rs139414 chr22:39553819 G/A cg12193277 chr22:39547181 CBX7 0.47 12.96 0.46 2.86e-34 Multiple myeloma; BRCA trans rs9858542 1.000 rs1131095 chr3:49714225 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.6 -0.36 1.78e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs61931739 0.500 rs7489270 chr12:34432062 C/T cg06521331 chr12:34319734 NA -0.56 -10.12 -0.37 2.01e-22 Morning vs. evening chronotype; BRCA cis rs1011018 0.628 rs17262662 chr7:139468767 A/G cg03224163 chr7:139420300 HIPK2 -0.52 -8.37 -0.31 3.63e-16 Systolic blood pressure; BRCA cis rs6570726 0.526 rs9376928 chr6:145724403 T/G cg23711669 chr6:146136114 FBXO30 -0.44 -9.52 -0.35 3.58e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7582180 0.629 rs13031508 chr2:100952757 A/G cg14675211 chr2:100938903 LONRF2 0.51 11.32 0.41 3.34e-27 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.43 -0.47 2.03e-36 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg21395723 chr22:39101663 GTPBP1 -0.42 -9.1 -0.34 1.15e-18 Menopause (age at onset); BRCA cis rs11718455 0.921 rs11130020 chr3:44009459 C/T cg08738300 chr3:44038990 NA 0.47 9.28 0.34 2.53e-19 Coronary artery disease; BRCA cis rs28735056 0.933 rs56181785 chr18:77633629 G/A cg20368463 chr18:77673604 PQLC1 -0.35 -8.06 -0.3 3.66e-15 Schizophrenia; BRCA cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 10.58 0.39 3.13e-24 Aortic root size; BRCA cis rs28374715 0.578 rs7165914 chr15:41632451 C/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.8 -0.71 4.21e-101 Ulcerative colitis; BRCA cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg10295955 chr4:187884368 NA 0.9 26.7 0.73 4.65e-106 Lobe attachment (rater-scored or self-reported); BRCA cis rs490234 0.841 rs7856366 chr9:128442229 A/G cg14078157 chr9:128172775 NA -0.4 -9.23 -0.34 3.83e-19 Mean arterial pressure; BRCA cis rs7789940 0.904 rs56919252 chr7:75937520 T/C cg10167463 chr7:75959203 YWHAG -0.44 -8.68 -0.32 3.3e-17 Multiple sclerosis; BRCA cis rs701145 0.556 rs355758 chr3:154007682 C/G cg16511985 chr3:153974050 SGEF -0.42 -9.6 -0.36 1.71e-20 Coronary artery disease; BRCA cis rs11249608 0.636 rs6888567 chr5:178449074 C/T cg21905437 chr5:178450457 ZNF879 -0.49 -10.43 -0.38 1.27e-23 Pubertal anthropometrics; BRCA cis rs523522 1.000 rs1563333 chr12:120934407 C/T cg27279351 chr12:120934652 DYNLL1 0.51 12.31 0.44 2.14e-31 High light scatter reticulocyte count; BRCA cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 2.0500000000000001e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg21248554 chr2:27665150 KRTCAP3 -0.34 -8.57 -0.32 7.64e-17 Total body bone mineral density; BRCA cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg10057126 chr4:77819792 ANKRD56 0.67 15.48 0.52 3.96e-46 Emphysema distribution in smoking; BRCA cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg15017067 chr4:17643749 FAM184B 0.35 10.93 0.4 1.31e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg19539972 chr4:7069911 GRPEL1 -0.63 -11.91 -0.43 1.08e-29 Monocyte percentage of white cells; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.83 -0.36 2.46e-21 Bipolar disorder and schizophrenia; BRCA cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg26384229 chr12:38710491 ALG10B 0.84 22.66 0.67 6.72e-84 Heart rate; BRCA cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg18876405 chr7:65276391 NA 0.55 13.35 0.47 4.99e-36 Aortic root size; BRCA cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9309711 0.961 rs11890651 chr2:3482796 T/G cg10845886 chr2:3471009 TTC15 -0.74 -16.35 -0.54 1.89e-50 Neurofibrillary tangles; BRCA cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg02297831 chr4:17616191 MED28 0.38 8.97 0.33 3.37e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg26597838 chr10:835615 NA 1.04 17.84 0.58 4.61e-58 Eosinophil percentage of granulocytes; BRCA cis rs10193935 0.901 rs10200353 chr2:42509554 A/G cg27598129 chr2:42591480 NA -0.95 -14.65 -0.5 4.33e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs6546550 0.933 rs6546554 chr2:70135706 G/A cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.93e-28 Prevalent atrial fibrillation; BRCA cis rs2742234 1.000 rs1864395 chr10:43655697 G/A cg02780029 chr10:43622663 RET -0.4 -10.05 -0.37 3.61e-22 Hirschsprung disease; BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg04166393 chr7:2884313 GNA12 0.5 9.55 0.35 2.61e-20 Height; BRCA cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg16386425 chr10:429943 DIP2C -0.42 -9.06 -0.34 1.6e-18 Psychosis in Alzheimer's disease; BRCA cis rs7824557 0.675 rs2736265 chr8:11186674 A/G cg21775007 chr8:11205619 TDH 0.75 18.71 0.59 1.27e-62 Retinal vascular caliber; BRCA cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.32 -9.63 -0.36 1.43e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg21573476 chr21:45109991 RRP1B 0.45 11.53 0.42 4.35e-28 Mean corpuscular volume; BRCA cis rs1003719 0.715 rs2835640 chr21:38537380 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.54 -0.5 1.43e-41 Eye color traits; BRCA cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 9.21 0.34 4.77e-19 Mean platelet volume; BRCA cis rs10165862 0.537 rs17009372 chr2:73955571 A/G cg20560298 chr2:73613845 ALMS1 0.4 8.25 0.31 8.93e-16 Intelligence (multi-trait analysis); BRCA cis rs7809950 0.784 rs7803102 chr7:107248929 T/G cg23024343 chr7:107201750 COG5 0.4 8.97 0.33 3.17e-18 Coronary artery disease; BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.56 -10.47 -0.38 8.67e-24 Renal function-related traits (BUN); BRCA cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs9329221 1.000 rs9329221 chr8:10240202 G/T cg27411982 chr8:10470053 RP1L1 0.32 7.88 0.3 1.42e-14 Neuroticism; BRCA cis rs7246967 0.673 rs12978794 chr19:22812134 C/T cg23217946 chr19:22817039 ZNF492 0.47 8.43 0.32 2.22e-16 Bronchopulmonary dysplasia; BRCA cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00475322 chr7:917719 C7orf20 0.45 11.92 0.43 1.01e-29 Perceived unattractiveness to mosquitoes; BRCA cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg05347473 chr6:146136440 FBXO30 0.44 8.65 0.32 4.22e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4988958 0.525 rs3771159 chr2:103004958 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.42 0.32 2.39e-16 Asthma (childhood onset); BRCA cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -11.77 -0.42 4.21e-29 Monocyte percentage of white cells; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.52 -10.97 -0.4 9.19e-26 Lymphocyte counts; BRCA cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs858239 0.539 rs57864591 chr7:23184424 T/A cg23682824 chr7:23144976 KLHL7 0.41 10.68 0.39 1.3e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs7917772 0.582 rs10786680 chr10:104317192 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.42 0.5 5.24e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg23625390 chr15:77176239 SCAPER -0.36 -8.59 -0.32 6.64e-17 Blood metabolite levels; BRCA cis rs7714584 1.000 rs1000113 chr5:150240076 C/T cg22134413 chr5:150180641 NA 0.65 9.83 0.36 2.57e-21 Crohn's disease; BRCA cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.48 0.52 3.74e-46 Colorectal cancer; BRCA cis rs3617 0.625 rs6445541 chr3:52880128 G/T cg11645453 chr3:52864694 ITIH4 0.32 8.26 0.31 8.48e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA trans rs7647973 0.626 rs62260720 chr3:49853796 T/A cg21659725 chr3:3221576 CRBN 0.48 8.84 0.33 9.32e-18 Menarche (age at onset); BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.31 -0.44 2.08e-31 Lymphocyte counts; BRCA cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.51 -0.47 9.38e-37 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.18 -0.49 7.04e-40 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg05340658 chr4:99064831 C4orf37 0.68 17.15 0.56 1.63e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg20701182 chr2:24300061 SF3B14 0.63 9.04 0.34 1.79e-18 Lymphocyte counts; BRCA cis rs672059 1.000 rs638781 chr1:183157358 T/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.64 0.32 4.48e-17 Hypertriglyceridemia; BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg23708337 chr7:1209742 NA 0.57 8.46 0.32 1.78e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35110281 0.667 rs2070533 chr21:45122753 G/A cg04455712 chr21:45112962 RRP1B 0.44 11.78 0.42 3.96e-29 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs10158032 chr1:46332701 T/C cg06784218 chr1:46089804 CCDC17 0.44 10.5 0.38 6.74e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.63 -13.09 -0.46 7.22e-35 Lymphocyte counts; BRCA cis rs2066819 1.000 rs1802236 chr12:56679751 A/G cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs2882667 0.690 rs311601 chr5:138053386 G/A cg04439458 chr5:138467593 SIL1 -0.34 -8.08 -0.3 3.12e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6750047 0.691 rs336032 chr2:38264788 T/C cg07380506 chr2:38303506 CYP1B1 -0.44 -9.61 -0.36 1.64e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg23711669 chr6:146136114 FBXO30 0.79 18.94 0.6 7.88e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.505 rs13503 chr10:38239843 C/A cg00409905 chr10:38381863 ZNF37A 0.5 10.72 0.39 9.22e-25 Extrinsic epigenetic age acceleration; BRCA trans rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg06453172 chr10:134556979 INPP5A -0.55 -11.5 -0.41 5.87e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -14.0 -0.48 4.93e-39 Platelet count; BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg08219700 chr8:58056026 NA 0.61 9.78 0.36 3.73e-21 Developmental language disorder (linguistic errors); BRCA cis rs593982 0.920 rs1151500 chr11:65481166 T/C cg08755490 chr11:65554678 OVOL1 1.13 17.16 0.56 1.47e-54 Atopic dermatitis; BRCA trans rs2797160 0.904 rs1739370 chr6:126011231 C/T cg05039488 chr6:79577232 IRAK1BP1 0.38 8.57 0.32 7.97e-17 Endometrial cancer; BRCA cis rs7666738 0.830 rs17548431 chr4:98923768 C/G cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 2.04e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs1459104 1.000 rs12574577 chr11:55306742 G/A cg15704280 chr7:45808275 SEPT13 0.64 7.94 0.3 9.33e-15 Body mass index; BRCA cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg06627628 chr2:24431161 ITSN2 -0.51 -8.28 -0.31 7.01e-16 Lymphocyte counts; BRCA cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.85 -0.33 8.29e-18 Alzheimer's disease (late onset); BRCA cis rs10992471 0.603 rs1980848 chr9:95248571 A/G cg14631576 chr9:95140430 CENPP 0.38 9.28 0.34 2.59e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg21770322 chr7:97807741 LMTK2 0.45 11.73 0.42 6.33e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg17366294 chr4:99064904 C4orf37 0.42 9.82 0.36 2.73e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs12497850 0.931 rs7627404 chr3:48819668 A/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.52 0.35 3.53e-20 Parkinson's disease; BRCA cis rs6973256 0.828 rs17167210 chr7:133339343 G/A cg07491979 chr7:133331646 EXOC4 -0.38 -8.55 -0.32 8.9e-17 Intelligence (multi-trait analysis); BRCA cis rs10769945 0.679 rs217213 chr11:1979118 C/G cg23202291 chr11:1979235 NA -0.35 -8.27 -0.31 7.62e-16 DNA methylation (variation); BRCA cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg21518248 chr2:162101506 NA -0.49 -10.43 -0.38 1.3e-23 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs9636840 chr21:32029979 A/G cg14062083 chr21:31802829 KRTAP13-4 -0.32 -8.59 -0.32 6.58e-17 HDL cholesterol; BRCA cis rs1401999 1.000 rs4148575 chr3:183702275 A/G cg01324343 chr3:183735012 ABCC5 0.83 21.1 0.64 2.27e-75 Anterior chamber depth; BRCA cis rs208515 0.556 rs12214562 chr6:66681011 T/A cg07460842 chr6:66804631 NA 0.87 15.63 0.53 7.42e-47 Exhaled nitric oxide levels; BRCA cis rs9814567 1.000 rs3846055 chr3:134203973 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.89 -0.33 6.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.8 13.71 0.48 1.05e-37 Alzheimer's disease; BRCA cis rs7809950 0.817 rs2712224 chr7:107181235 C/A cg23024343 chr7:107201750 COG5 -0.49 -9.91 -0.36 1.26e-21 Coronary artery disease; BRCA cis rs16854884 0.657 rs1867609 chr3:143752916 A/G cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA cis rs73001065 0.901 rs8107974 chr19:19388500 A/T cg03709012 chr19:19516395 GATAD2A 0.79 9.3 0.35 2.11e-19 LDL cholesterol; BRCA cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg05472934 chr7:22766657 IL6 0.52 13.78 0.48 4.96e-38 Lung cancer; BRCA cis rs7647973 0.593 rs28535523 chr3:49848414 C/T cg07636037 chr3:49044803 WDR6 -0.49 -8.13 -0.31 2.23e-15 Menarche (age at onset); BRCA cis rs6063312 0.667 rs9679994 chr20:47281853 T/C cg18078177 chr20:47281410 PREX1 0.75 17.85 0.58 3.93e-58 Tonometry; BRCA cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg13271783 chr10:134563150 INPP5A -0.46 -9.72 -0.36 6.22e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs875971 0.502 rs2946580 chr7:65531842 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.45 -0.38 1.07e-23 Aortic root size; BRCA cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg11833968 chr6:79620685 NA -0.41 -9.21 -0.34 4.65e-19 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -8.7 -0.33 2.88e-17 Triglycerides; BRCA trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.13 0.43 1.31e-30 Corneal astigmatism; BRCA cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.83 0.36 2.48e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs208520 0.955 rs9453664 chr6:66976079 A/C cg07460842 chr6:66804631 NA 0.68 11.41 0.41 1.47e-27 Exhaled nitric oxide output; BRCA cis rs4975616 0.686 rs37011 chr5:1348798 A/T cg06550200 chr5:1325588 CLPTM1L -0.59 -12.56 -0.45 1.64e-32 Lung cancer; BRCA cis rs10911232 0.507 rs10797815 chr1:182996827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg25554036 chr4:6271136 WFS1 0.42 10.16 0.37 1.35e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9487051 0.724 rs13200047 chr6:109633244 T/C cg21918786 chr6:109611834 NA -0.36 -8.75 -0.33 1.94e-17 Reticulocyte fraction of red cells; BRCA cis rs561341 1.000 rs501312 chr17:30329066 A/G cg12193833 chr17:30244370 NA -0.55 -8.69 -0.33 2.99e-17 Hip circumference adjusted for BMI; BRCA cis rs60843830 1.000 rs58461606 chr2:267367 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.36 0.49 1.03e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg00684032 chr4:1343700 KIAA1530 0.52 12.51 0.44 2.94e-32 Obesity-related traits; BRCA cis rs7209700 0.745 rs8074348 chr17:45353413 G/C cg08085267 chr17:45401833 C17orf57 0.43 8.2 0.31 1.33e-15 IgG glycosylation; BRCA cis rs9462846 0.919 rs6936722 chr6:42891311 A/G cg02353165 chr6:42928485 GNMT -0.49 -9.49 -0.35 4.38e-20 Blood protein levels; BRCA cis rs7945705 0.905 rs7947631 chr11:8844909 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.42 -9.0 -0.34 2.61e-18 Hemoglobin concentration; BRCA cis rs7412746 0.658 rs59024312 chr1:150909005 T/G cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.24e-14 Melanoma; BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26314531 chr2:26401878 FAM59B 0.65 11.38 0.41 1.83e-27 Gut microbiome composition (summer); BRCA cis rs2354432 0.607 rs7523812 chr1:146673489 A/G cg25205988 chr1:146714368 CHD1L -0.81 -10.84 -0.39 2.93e-25 Mitochondrial DNA levels; BRCA cis rs861020 1.000 rs680923 chr1:209986672 T/C cg05527609 chr1:210001259 C1orf107 0.7 15.04 0.51 5.66e-44 Orofacial clefts; BRCA cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg04756594 chr16:24857601 SLC5A11 0.34 8.53 0.32 1.09e-16 Intelligence (multi-trait analysis); BRCA cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg22903471 chr2:27725779 GCKR -0.35 -8.58 -0.32 7.26e-17 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg24101359 chr6:42928495 GNMT -0.64 -15.09 -0.51 2.97e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs59918340 0.728 rs59172574 chr8:142231945 C/G cg23750338 chr8:142222470 SLC45A4 0.51 12.48 0.44 3.85e-32 Immature fraction of reticulocytes; BRCA cis rs3771570 1.000 rs59536819 chr2:242272388 A/G cg21155796 chr2:242212141 HDLBP 0.61 9.41 0.35 8.68e-20 Prostate cancer; BRCA cis rs561341 1.000 rs542132 chr17:30307193 A/T cg12193833 chr17:30244370 NA -0.54 -8.72 -0.33 2.47e-17 Hip circumference adjusted for BMI; BRCA cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg02466173 chr16:30829666 NA -0.43 -9.69 -0.36 8.6e-21 Dementia with Lewy bodies; BRCA cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg13393036 chr8:95962371 TP53INP1 -0.3 -8.07 -0.3 3.54e-15 Type 2 diabetes; BRCA cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg26769984 chr7:1090371 C7orf50 0.65 11.49 0.41 6.73e-28 Bronchopulmonary dysplasia; BRCA cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg20701182 chr2:24300061 SF3B14 0.57 8.95 0.33 3.98e-18 Lymphocyte counts; BRCA cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.92 0.43 9.97e-30 Mean platelet volume; BRCA cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg12373951 chr3:133503437 NA 0.35 8.03 0.3 4.64e-15 Iron status biomarkers; BRCA cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg15103426 chr22:29168792 CCDC117 0.52 12.24 0.44 4.21e-31 Lymphocyte counts; BRCA cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg22307297 chr20:60903441 LAMA5 -0.29 -7.89 -0.3 1.33e-14 Colorectal cancer; BRCA trans rs6600671 0.932 rs6600663 chr1:121222437 A/T cg17023122 chr1:144479586 NA 0.35 8.04 0.3 4.29e-15 Hip geometry; BRCA cis rs9325144 0.671 rs7486919 chr12:38767997 A/G cg26384229 chr12:38710491 ALG10B -0.51 -12.1 -0.43 1.7e-30 Morning vs. evening chronotype; BRCA cis rs911555 0.755 rs7148567 chr14:103882234 C/T cg24130564 chr14:104152367 KLC1 -0.39 -8.8 -0.33 1.28e-17 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg24633833 chr3:10029261 TMEM111 0.4 7.91 0.3 1.15e-14 Alzheimer's disease; BRCA cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.63 -12.27 -0.44 3.18e-31 Chronic sinus infection; BRCA cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg26818010 chr10:134567672 INPP5A -0.71 -15.13 -0.51 2.06e-44 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.63 -0.42 1.67e-28 Electroencephalogram traits; BRCA cis rs6028335 0.610 rs1130247 chr20:37581437 A/G cg16355469 chr20:37678765 NA 0.44 8.11 0.31 2.55e-15 Alcohol and nicotine co-dependence; BRCA cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg10792982 chr14:105748885 BRF1 0.5 11.45 0.41 9.38e-28 Mean platelet volume;Platelet distribution width; BRCA cis rs875971 0.862 rs801203 chr7:66023012 A/G cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA cis rs9487051 0.735 rs351745 chr6:109529169 C/T cg21918786 chr6:109611834 NA 0.36 9.72 0.36 6.32e-21 Reticulocyte fraction of red cells; BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.73 0.42 6.61e-29 Tonsillectomy; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs4363385 0.510 rs6677674 chr1:153037601 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -7.96 -0.3 7.69e-15 Inflammatory skin disease; BRCA cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg02574844 chr11:5959923 NA -0.43 -8.65 -0.32 4.08e-17 DNA methylation (variation); BRCA cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg01579765 chr21:45077557 HSF2BP -0.42 -10.94 -0.4 1.21e-25 Mean corpuscular volume; BRCA cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg14019146 chr3:50243930 SLC38A3 0.63 16.11 0.54 2.85e-49 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg15145296 chr3:125709740 NA -0.54 -8.58 -0.32 7.1e-17 Blood pressure (smoking interaction); BRCA cis rs765787 0.530 rs4774542 chr15:45526026 A/C cg24006582 chr15:45444508 DUOX1 0.5 10.18 0.37 1.19e-22 Uric acid levels; BRCA cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.61e-50 Alzheimer's disease (late onset); BRCA cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 8.75e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.11 0.4 2.4e-26 Bipolar disorder; BRCA cis rs7481584 0.624 rs12417389 chr11:3035304 G/C cg25174290 chr11:3078921 CARS -0.3 -7.88 -0.3 1.45e-14 Calcium levels; BRCA cis rs708547 0.957 rs781667 chr4:57798469 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -8.33 -0.31 4.91e-16 Response to bleomycin (chromatid breaks); BRCA cis rs4363385 0.747 rs6668215 chr1:152964498 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.44 -0.35 6.77e-20 Inflammatory skin disease; BRCA cis rs9341808 0.718 rs9448908 chr6:80898069 C/T cg08355045 chr6:80787529 NA 0.39 9.87 0.36 1.83e-21 Sitting height ratio; BRCA cis rs6964587 1.000 rs9784993 chr7:91672403 G/A cg01689657 chr7:91764605 CYP51A1 0.21 7.84 0.3 1.9e-14 Breast cancer; BRCA cis rs4900538 0.855 rs60215817 chr14:102873886 A/G cg18135206 chr14:102964638 TECPR2 -0.92 -21.74 -0.65 7.08e-79 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs6952808 0.656 rs73048919 chr7:2103637 C/A cg04565464 chr8:145669602 NFKBIL2 0.43 9.72 0.36 6.5e-21 Bipolar disorder and schizophrenia; BRCA cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg14403583 chr14:105418241 AHNAK2 0.38 9.0 0.34 2.66e-18 Rheumatoid arthritis; BRCA cis rs12586317 0.553 rs78124218 chr14:35570606 G/A cg05294307 chr14:35346193 BAZ1A -0.58 -10.21 -0.37 8.65e-23 Psoriasis; BRCA cis rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.2e-20 Endometrial cancer; BRCA cis rs36051895 0.559 rs7858422 chr9:5209797 G/T cg02405213 chr9:5042618 JAK2 -0.43 -8.23 -0.31 1.08e-15 Pediatric autoimmune diseases; BRCA cis rs734999 0.933 rs4648648 chr1:2512452 G/A cg20673091 chr1:2541236 MMEL1 0.36 9.3 0.35 2.12e-19 Ulcerative colitis; BRCA cis rs11785693 0.862 rs11784262 chr8:4996942 G/A cg26367366 chr8:4980734 NA 0.63 11.37 0.41 2.05e-27 Neuroticism (multi-trait analysis);Neuroticism; BRCA trans rs208520 0.690 rs12204512 chr6:66710486 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 20.19 0.62 1.64e-70 Exhaled nitric oxide output; BRCA cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg18876405 chr7:65276391 NA -0.62 -15.37 -0.52 1.33e-45 Aortic root size; BRCA cis rs9467773 0.583 rs2498380 chr6:26643996 C/G cg09904177 chr6:26538194 HMGN4 -0.46 -14.45 -0.5 3.55e-41 Intelligence (multi-trait analysis); BRCA cis rs875971 1.000 rs697970 chr7:65560052 G/C cg12463550 chr7:65579703 CRCP -0.39 -8.19 -0.31 1.42e-15 Aortic root size; BRCA cis rs17270561 0.609 rs9393658 chr6:25730438 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg08917208 chr2:24149416 ATAD2B 0.9 13.14 0.46 4.57e-35 Lymphocyte counts; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg14863265 chr7:2801509 GNA12 -0.45 -9.76 -0.36 4.5e-21 Height; BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.0 -0.34 2.59e-18 Menopause (age at onset); BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg03188948 chr7:1209495 NA 0.43 7.86 0.3 1.65e-14 Longevity;Endometriosis; BRCA cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg18876405 chr7:65276391 NA 0.48 10.03 0.37 4.45e-22 Calcium levels; BRCA cis rs2832191 0.655 rs2247110 chr21:30323888 G/A cg24692254 chr21:30365293 RNF160 -0.79 -21.73 -0.65 8.08e-79 Dental caries; BRCA cis rs7412746 0.658 rs57818453 chr1:150763139 G/A cg15448220 chr1:150897856 SETDB1 0.36 8.09 0.3 3.11e-15 Melanoma; BRCA cis rs7607369 0.782 rs514799 chr2:219411203 A/G cg10223061 chr2:219282414 VIL1 -0.27 -8.02 -0.3 5.02e-15 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs9399137 0.507 rs4451150 chr6:135279063 T/G cg24558204 chr6:135376177 HBS1L 0.58 15.53 0.52 2.27e-46 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg16339924 chr4:17578868 LAP3 -0.55 -13.5 -0.47 1.03e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.91 -0.43 1.16e-29 Personality dimensions; BRCA cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg12310025 chr6:25882481 NA -0.55 -12.23 -0.44 4.93e-31 Intelligence (multi-trait analysis); BRCA cis rs2115630 1.000 rs11854291 chr15:85363708 T/C cg11189052 chr15:85197271 WDR73 -0.36 -8.55 -0.32 8.77e-17 P wave terminal force; BRCA cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg01874867 chr7:94954059 PON1 -0.39 -7.97 -0.3 7.31e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs858239 0.601 rs6971002 chr7:23172304 C/G cg23682824 chr7:23144976 KLHL7 0.42 11.24 0.41 7.05e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs11190604 1.000 rs7073586 chr10:102307671 A/G cg07080220 chr10:102295463 HIF1AN 0.57 13.31 0.47 7.63e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7737355 0.947 rs28720007 chr5:131077709 C/T cg06307176 chr5:131281290 NA 0.52 10.08 0.37 2.86e-22 Life satisfaction; BRCA cis rs1865760 0.929 rs9467646 chr6:25957408 A/G cg17691542 chr6:26056736 HIST1H1C 0.49 10.02 0.37 4.91e-22 Height; BRCA cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.52 8.2 0.31 1.35e-15 Renal function-related traits (BUN); BRCA cis rs2011503 1.000 rs2916070 chr19:19524105 C/T cg11584989 chr19:19387371 SF4 0.63 13.36 0.47 4.2500000000000003e-36 Bipolar disorder; BRCA cis rs9399135 0.967 rs7750300 chr6:135350950 C/G cg24558204 chr6:135376177 HBS1L 0.45 12.23 0.44 4.56e-31 Red blood cell count; BRCA cis rs10911232 0.507 rs10797819 chr1:183006911 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.92 0.56 2.39e-53 Hypertriglyceridemia; BRCA cis rs9287719 0.967 rs6432122 chr2:10753844 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg02951883 chr7:2050386 MAD1L1 -0.43 -10.44 -0.38 1.18e-23 Schizophrenia; BRCA cis rs7246967 0.673 rs12979848 chr19:22820798 G/A cg23217946 chr19:22817039 ZNF492 0.47 8.48 0.32 1.56e-16 Bronchopulmonary dysplasia; BRCA cis rs7267979 1.000 rs453329 chr20:25440593 G/A cg08601574 chr20:25228251 PYGB 0.34 8.13 0.31 2.25e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg04317338 chr11:64019027 PLCB3 0.53 9.35 0.35 1.41e-19 Mean platelet volume; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg00166722 chr3:10149974 C3orf24 0.65 13.02 0.46 1.52e-34 Alzheimer's disease; BRCA trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg11707556 chr5:10655725 ANKRD33B -0.38 -9.35 -0.35 1.42e-19 Coronary artery disease; BRCA cis rs35123781 0.654 rs356486 chr5:139085103 C/G cg10513866 chr5:139070639 NA -0.44 -9.94 -0.37 9.98e-22 Schizophrenia; BRCA cis rs6750047 0.647 rs11124632 chr2:38276412 G/C cg07380506 chr2:38303506 CYP1B1 0.48 10.53 0.38 4.98e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs1997103 0.911 rs11238361 chr7:55395981 A/G cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.02e-18 Height; BRCA cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg11266682 chr4:10021025 SLC2A9 0.42 11.4 0.41 1.61e-27 Bone mineral density; BRCA cis rs2286885 1.000 rs7851961 chr9:129249140 G/A cg15282417 chr9:129245246 FAM125B 0.31 7.87 0.3 1.5e-14 Intraocular pressure; BRCA cis rs12618769 0.597 rs56197140 chr2:99113740 T/C cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.53e-16 Bipolar disorder; BRCA cis rs724568 0.546 rs974482 chr2:67946520 C/A cg17945962 chr2:67939740 NA -0.39 -10.5 -0.38 6.74e-24 Major depressive disorder (broad); BRCA cis rs6763687 0.725 rs11717882 chr3:171804170 T/A cg16233210 chr3:171778391 FNDC3B 0.36 8.0 0.3 6.05e-15 Red cell distribution width; BRCA cis rs921968 0.565 rs4674329 chr2:219595507 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.07 -0.4 3.49e-26 Mean corpuscular hemoglobin concentration; BRCA trans rs11088226 0.645 rs7281844 chr21:33932435 T/C cg09050820 chr6:167586206 TCP10L2 0.76 13.46 0.47 1.6e-36 Gastritis; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg05552183 chr6:42928497 GNMT 0.7 15.75 0.53 1.77e-47 Plasma homocysteine levels (post-methionine load test); BRCA cis rs9463078 0.774 rs9357480 chr6:45219512 G/A cg25276700 chr6:44698697 NA -0.35 -7.92 -0.3 1.03e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs13108904 0.901 rs1316394 chr4:1315820 G/A cg00684032 chr4:1343700 KIAA1530 0.43 10.44 0.38 1.16e-23 Obesity-related traits; BRCA cis rs7561273 0.609 rs6545285 chr2:24340029 T/C cg04809136 chr2:24300158 SF3B14 -0.4 -8.98 -0.33 2.99e-18 Quantitative traits; BRCA cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.81 -23.19 -0.68 9.1e-87 Chronic sinus infection; BRCA cis rs9467773 1.000 rs10946834 chr6:26533664 G/C cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg02951883 chr7:2050386 MAD1L1 -0.38 -9.13 -0.34 8.9e-19 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.830 rs1593573 chr4:98925293 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg19077165 chr18:44547161 KATNAL2 -0.5 -10.86 -0.39 2.48e-25 Personality dimensions; BRCA cis rs9814567 1.000 rs6785027 chr3:134211649 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.59 19.67 0.61 1.01e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11098499 0.738 rs34566984 chr4:120361270 G/A cg09307838 chr4:120376055 NA 0.74 15.98 0.53 1.38e-48 Corneal astigmatism; BRCA cis rs875971 0.862 rs3893216 chr7:65790707 G/C cg18876405 chr7:65276391 NA -0.5 -11.2 -0.41 1.06e-26 Aortic root size; BRCA cis rs11971779 0.680 rs11768023 chr7:139054395 T/A cg07862535 chr7:139043722 LUC7L2 0.39 10.55 0.39 4.26e-24 Diisocyanate-induced asthma; BRCA cis rs12618769 0.652 rs4851146 chr2:99237439 A/G cg10123293 chr2:99228465 UNC50 0.41 8.09 0.3 2.9e-15 Bipolar disorder; BRCA cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg03452623 chr4:187889614 NA -0.3 -9.47 -0.35 5.37e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7766436 0.770 rs11751669 chr6:22571037 A/G cg13666174 chr6:22585274 NA -0.44 -9.63 -0.36 1.32e-20 Coronary artery disease; BRCA cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.22 -0.37 8.46e-23 Psoriasis; BRCA cis rs17376456 0.877 rs9314099 chr5:93447375 T/C cg21475434 chr5:93447410 FAM172A 0.68 9.22 0.34 4.38e-19 Diabetic retinopathy; BRCA cis rs796364 0.806 rs10445792 chr2:201078821 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -9.24 -0.34 3.53e-19 Schizophrenia; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg23131131 chr22:24373011 LOC391322 0.41 9.44 0.35 6.98e-20 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs13136331 0.684 rs12505482 chr4:88730210 T/C cg22416721 chr4:88570574 DMP1 0.39 8.09 0.3 3.09e-15 Sitting height ratio; BRCA cis rs2243480 1.000 rs316312 chr7:65596491 T/G cg18252515 chr7:66147081 NA -1.07 -15.7 -0.53 3.09e-47 Diabetic kidney disease; BRCA cis rs3771570 0.901 rs4675964 chr2:242324760 A/C cg21155796 chr2:242212141 HDLBP 0.47 8.22 0.31 1.1e-15 Prostate cancer; BRCA cis rs4930561 0.714 rs6591335 chr11:67976812 T/C cg04465784 chr11:67976953 SUV420H1 -0.26 -8.49 -0.32 1.43e-16 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs3733585 0.699 rs2018643 chr4:9947121 C/T cg00071950 chr4:10020882 SLC2A9 0.44 10.33 0.38 3.22e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg13319975 chr6:146136371 FBXO30 -0.46 -10.53 -0.38 5.16e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs1568889 0.712 rs10835306 chr11:28302410 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 19.55 0.61 4.51e-67 Bipolar disorder; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -12.92 -0.46 4.37e-34 Platelet count; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg23708337 chr7:1209742 NA 0.55 11.64 0.42 1.58e-28 Longevity;Endometriosis; BRCA trans rs637571 0.676 rs1151523 chr11:65665200 C/T cg17712092 chr4:129076599 LARP1B -0.68 -17.22 -0.56 7.36e-55 Eosinophil percentage of white cells; BRCA cis rs1506636 0.962 rs1472808 chr7:123354536 A/G cg03229431 chr7:123269106 ASB15 -0.61 -13.96 -0.48 7.91e-39 Plateletcrit;Platelet count; BRCA cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg00631329 chr6:26305371 NA -0.48 -13.63 -0.47 2.57e-37 Educational attainment; BRCA cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg20887711 chr4:1340912 KIAA1530 0.75 16.07 0.54 4.43e-49 Longevity; BRCA cis rs908922 0.651 rs7529157 chr1:152531365 C/A cg20991723 chr1:152506922 NA 0.36 8.13 0.31 2.24e-15 Hair morphology; BRCA cis rs514406 0.825 rs487453 chr1:53271225 T/C cg25767906 chr1:53392781 SCP2 0.38 8.79 0.33 1.4e-17 Monocyte count; BRCA cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg12564285 chr5:131593104 PDLIM4 0.35 9.13 0.34 8.68e-19 Blood metabolite levels; BRCA cis rs8028182 0.636 rs28737338 chr15:75768679 C/T cg20655648 chr15:75932815 IMP3 0.4 8.0 0.3 5.97e-15 Sudden cardiac arrest; BRCA cis rs7179456 0.515 rs602602 chr15:59057023 T/A cg05156742 chr15:59063176 FAM63B 0.41 8.14 0.31 2.02e-15 Asperger disorder; BRCA cis rs1003719 0.788 rs2835577 chr21:38457457 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.18 0.49 7.11e-40 Eye color traits; BRCA cis rs1865760 0.964 rs9295677 chr6:25933712 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.76 0.36 4.41e-21 Height; BRCA trans rs911555 0.723 rs6575991 chr14:103908433 C/T cg17675199 chr6:35436792 RPL10A -0.3 -8.03 -0.3 4.8e-15 Intelligence (multi-trait analysis); BRCA cis rs9527 0.590 rs10883829 chr10:104840635 T/C cg04362960 chr10:104952993 NT5C2 0.44 9.85 0.36 2.09e-21 Arsenic metabolism; BRCA cis rs9649465 0.688 rs34967330 chr7:123318560 A/C cg04330084 chr7:123175371 IQUB -0.33 -8.89 -0.33 6.2e-18 Migraine; BRCA cis rs9283706 0.689 rs1030231 chr5:66317265 A/G cg11590213 chr5:66331682 MAST4 0.41 8.23 0.31 1.07e-15 Coronary artery disease; BRCA cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.62 13.17 0.46 3.37e-35 Age-related macular degeneration (geographic atrophy); BRCA cis rs365132 1.000 rs402511 chr5:176434440 G/A cg16309518 chr5:176445507 NA -0.52 -13.35 -0.47 4.77e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.49 0.52 3.55e-46 Colorectal cancer; BRCA cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg11833968 chr6:79620685 NA -0.45 -10.02 -0.37 4.82e-22 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.45 0.38 1.08e-23 Motion sickness; BRCA cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg18964960 chr10:1102726 WDR37 0.63 8.71 0.33 2.65e-17 Eosinophil percentage of granulocytes; BRCA cis rs854765 0.547 rs4072739 chr17:17884660 G/A cg24612305 chr17:17875800 TOM1L2;LRRC48 0.53 15.29 0.52 3.15e-45 Total body bone mineral density; BRCA cis rs243505 0.898 rs243529 chr7:148413801 G/A cg09806900 chr7:148480153 CUL1 -0.4 -8.23 -0.31 1.07e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3733585 0.605 rs4235354 chr4:10122942 C/A cg11266682 chr4:10021025 SLC2A9 -0.39 -9.85 -0.36 2.07e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12756686 chr19:29218302 NA 0.57 10.98 0.4 8.46e-26 Methadone dose in opioid dependence; BRCA cis rs4764124 0.646 rs11610238 chr12:14975721 C/T cg19759883 chr12:14956454 WBP11;C12orf60 0.51 12.34 0.44 1.51e-31 Pubertal anthropometrics; BRCA cis rs9486719 1.000 rs9373978 chr6:97056255 T/C cg06623918 chr6:96969491 KIAA0776 -0.76 -13.41 -0.47 2.67e-36 Migraine;Coronary artery disease; BRCA cis rs10193935 0.901 rs13384885 chr2:42536646 G/C cg27598129 chr2:42591480 NA -0.94 -14.87 -0.51 3.63e-43 Colonoscopy-negative controls vs population controls; BRCA trans rs12458462 0.812 rs34583578 chr18:77491070 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.45 -8.25 -0.31 9.07e-16 Monocyte count; BRCA trans rs2204008 0.594 rs11531211 chr12:37998007 T/G cg06521331 chr12:34319734 NA 0.44 8.72 0.33 2.48e-17 Bladder cancer; BRCA cis rs757110 0.933 rs7124355 chr11:17412960 C/T cg15432903 chr11:17409602 KCNJ11 -0.54 -11.24 -0.41 6.97e-27 Type 2 diabetes; BRCA trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg03929089 chr4:120376271 NA -0.44 -8.25 -0.31 8.93e-16 HDL cholesterol; BRCA cis rs936229 1.000 rs936228 chr15:75132164 T/C cg14664628 chr15:75095509 CSK -0.89 -24.29 -0.69 7.7e-93 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs858239 0.899 rs2268747 chr7:23313462 A/G cg23682824 chr7:23144976 KLHL7 0.35 8.8 0.33 1.32e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 16.45 0.55 5.62e-51 Platelet count; BRCA cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -10.98 -0.4 7.88e-26 IgG glycosylation; BRCA cis rs13394619 1.000 rs13394619 chr2:11727507 A/G cg07314298 chr2:11723111 GREB1 0.52 11.71 0.42 8.27e-29 Endometriosis; BRCA cis rs10465746 0.967 rs11163879 chr1:84444051 T/C cg10977910 chr1:84465055 TTLL7 0.51 10.36 0.38 2.4e-23 Obesity-related traits; BRCA cis rs6542838 0.641 rs12467189 chr2:99495820 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.11 -0.34 1.05e-18 Fear of minor pain; BRCA cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.35 0.31 4.12e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg00531865 chr16:30841666 NA 0.4 9.49 0.35 4.62e-20 Dementia with Lewy bodies; BRCA cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs11608355 0.545 rs12823587 chr12:109896390 A/G cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs3741404 0.574 rs616563 chr11:63877501 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 14.88 0.51 3.38e-43 Platelet count; BRCA cis rs875971 0.895 rs12698520 chr7:65918707 C/A cg11764359 chr7:65958608 NA 0.8 19.29 0.61 1.15e-65 Aortic root size; BRCA cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.18 0.43 7.6e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg18765753 chr7:1198926 ZFAND2A -0.51 -11.84 -0.42 2.19e-29 Longevity;Endometriosis; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg01483505 chr11:975446 AP2A2 0.3 7.9 0.3 1.27e-14 Alzheimer's disease (late onset); BRCA cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs208520 0.690 rs12202913 chr6:66734198 C/T cg07460842 chr6:66804631 NA 0.99 19.84 0.62 1.25e-68 Exhaled nitric oxide output; BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg25036284 chr2:26402008 FAM59B -0.79 -12.4 -0.44 8.96e-32 Gut microbiome composition (summer); BRCA cis rs870825 0.616 rs7678616 chr4:185648714 T/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs10267417 0.603 rs10229973 chr7:19894778 G/A cg05791153 chr7:19748676 TWISTNB 0.47 9.04 0.34 1.9e-18 Night sleep phenotypes; BRCA cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg27129171 chr3:47204927 SETD2 -0.67 -15.6 -0.53 1.06e-46 Colorectal cancer; BRCA cis rs700651 0.752 rs1850631 chr2:198829468 T/G cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.47e-21 Intracranial aneurysm; BRCA cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg00990874 chr7:1149470 C7orf50 -0.6 -12.13 -0.43 1.22e-30 Bronchopulmonary dysplasia; BRCA cis rs72634258 0.554 rs7556518 chr1:7847846 G/A cg26816564 chr1:7831052 VAMP3 0.68 12.52 0.44 2.45e-32 Inflammatory bowel disease; BRCA cis rs1801251 0.896 rs6719061 chr2:233695885 C/T cg25237894 chr2:233734115 C2orf82 -0.38 -11.06 -0.4 3.89e-26 Coronary artery disease; BRCA cis rs6912958 0.559 rs183599 chr6:88061024 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.12 0.4 2.29e-26 Monocyte percentage of white cells; BRCA cis rs7520050 0.933 rs6666743 chr1:46311275 C/T cg24296786 chr1:45957014 TESK2 0.41 9.34 0.35 1.51e-19 Red blood cell count;Reticulocyte count; BRCA cis rs870825 0.860 rs72703525 chr4:185605154 T/C cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs4713118 0.513 rs183244 chr6:28031838 C/A cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.9 0.3 1.25e-14 Parkinson's disease; BRCA cis rs1127311 1.000 rs10908419 chr1:154567699 G/A cg17218026 chr1:154582156 ADAR 0.28 8.42 0.32 2.5e-16 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs7647973 0.592 rs6774202 chr3:49687779 T/G cg03060546 chr3:49711283 APEH 0.57 9.92 0.37 1.17e-21 Menarche (age at onset); BRCA trans rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05039488 chr6:79577232 IRAK1BP1 0.36 8.07 0.3 3.49e-15 Endometrial cancer; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg21280719 chr6:42927975 GNMT -0.33 -13.75 -0.48 7.26e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs8062405 0.755 rs4787455 chr16:28589455 G/A cg16576597 chr16:28551801 NUPR1 0.35 9.46 0.35 5.9e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs13095912 0.778 rs11914529 chr3:185296513 C/T cg11274856 chr3:185301563 NA 0.55 13.27 0.46 1.18e-35 Systolic blood pressure; BRCA cis rs922692 0.710 rs1994016 chr15:79080234 C/T cg04896959 chr15:78267971 NA 0.38 8.82 0.33 1.05e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA trans rs11098499 0.954 rs12505469 chr4:120249585 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.24 0.31 9.83e-16 Corneal astigmatism; BRCA cis rs9811920 0.931 rs7629487 chr3:99860401 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 12.78 0.45 1.81e-33 Axial length; BRCA cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg06191203 chr2:152266755 RIF1 -0.41 -11.18 -0.4 1.27e-26 Lung cancer; BRCA cis rs965469 1.000 rs6051827 chr20:3372007 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -10.08 -0.37 2.77e-22 IFN-related cytopenia; BRCA cis rs55883249 0.957 rs10495572 chr2:9734859 C/G cg23886495 chr2:9695866 ADAM17 -0.54 -7.92 -0.3 1.04e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA trans rs10838798 0.504 rs1483123 chr11:48326773 G/A cg00717180 chr2:96193071 NA -0.37 -10.27 -0.38 5.04e-23 Height; BRCA cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg19717773 chr7:2847554 GNA12 -0.43 -9.55 -0.35 2.75e-20 Height; BRCA trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6714710 0.580 rs55886305 chr2:98495661 T/G cg26665480 chr2:98280029 ACTR1B 0.58 13.49 0.47 1.14e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs3772130 0.540 rs7649436 chr3:121562304 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.67 14.61 0.5 6.27e-42 Cognitive performance; BRCA cis rs796364 0.539 rs6738494 chr2:200697058 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.55 8.57 0.32 7.75e-17 Schizophrenia; BRCA cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.18 -0.31 1.59e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.73e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg15832292 chr6:96025679 MANEA 0.55 8.29 0.31 6.76e-16 Behavioural disinhibition (generation interaction); BRCA trans rs61931739 0.500 rs3922568 chr12:34560107 A/C cg26384229 chr12:38710491 ALG10B 0.6 13.71 0.48 1.06e-37 Morning vs. evening chronotype; BRCA cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.44 0.44 5.6e-32 Electroencephalogram traits; BRCA trans rs11098499 0.863 rs7695620 chr4:120452776 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs6089584 0.508 rs6061988 chr20:60626300 C/T cg06108461 chr20:60628389 TAF4 -0.75 -15.75 -0.53 1.73e-47 Body mass index; BRCA cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg06784218 chr1:46089804 CCDC17 0.52 12.61 0.45 1.01e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs11098499 0.863 rs1010739 chr4:120463471 C/T cg25214090 chr10:38739885 LOC399744 0.59 12.67 0.45 5.44e-33 Corneal astigmatism; BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.06 0.34 1.53e-18 Tonsillectomy; BRCA cis rs1707322 0.963 rs11211202 chr1:46292382 C/T cg03146154 chr1:46216737 IPP 0.45 10.14 0.37 1.69e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2288912 0.808 rs35670684 chr19:45455985 A/C cg20090143 chr19:45452003 APOC2 0.27 7.87 0.3 1.47e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs6952808 0.689 rs58227534 chr7:2046328 A/G cg04565464 chr8:145669602 NFKBIL2 0.37 8.75 0.33 1.96e-17 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg21573476 chr21:45109991 RRP1B -0.37 -9.61 -0.36 1.65e-20 Mean corpuscular volume; BRCA cis rs2243480 1.000 rs958550 chr7:65635679 C/T cg18252515 chr7:66147081 NA 0.94 13.98 0.48 6.12e-39 Diabetic kidney disease; BRCA cis rs4664304 0.710 rs9636280 chr2:160717852 C/T cg18514922 chr2:160761262 LY75 -0.35 -8.28 -0.31 7.44e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg10523679 chr1:76189770 ACADM -0.59 -11.06 -0.4 3.76e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504073 0.647 rs55920380 chr8:50026353 G/A cg00325661 chr8:49890786 NA 0.44 12.37 0.44 1.21e-31 Blood metabolite ratios; BRCA cis rs1577917 0.958 rs12202712 chr6:86578541 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.29 -0.41 4.61e-27 Response to antipsychotic treatment; BRCA cis rs1863824 0.595 rs61859067 chr10:88159997 G/A cg07322936 chr10:88137208 NA -0.45 -9.02 -0.34 2.23e-18 Schizophrenia; BRCA cis rs6912958 0.781 rs9444519 chr6:88290398 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs9359856 0.564 rs72913975 chr6:90387116 C/T cg13799429 chr6:90582589 CASP8AP2 -0.68 -8.82 -0.33 1.07e-17 Bipolar disorder; BRCA cis rs9875589 0.509 rs2129888 chr3:14013826 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.33 8.6 0.32 6.24e-17 Ovarian reserve; BRCA cis rs68170813 0.641 rs61511581 chr7:106948091 T/A cg02696742 chr7:106810147 HBP1 -0.49 -8.54 -0.32 9.54e-17 Coronary artery disease; BRCA cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg22875332 chr1:76189707 ACADM 0.57 10.64 0.39 1.88e-24 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6912958 0.559 rs451465 chr6:88043372 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.38 -10.82 -0.39 3.57e-25 Monocyte percentage of white cells; BRCA cis rs7647973 1.000 rs11130190 chr3:49402137 T/C cg07636037 chr3:49044803 WDR6 0.74 15.91 0.53 3.01e-48 Menarche (age at onset); BRCA trans rs2197308 0.692 rs7488528 chr12:37912971 G/A cg06521331 chr12:34319734 NA -0.53 -9.43 -0.35 7.17e-20 Morning vs. evening chronotype; BRCA cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg23033748 chr14:75592666 NEK9 -0.39 -9.19 -0.34 5.61e-19 Height; BRCA trans rs7395662 0.591 rs11039858 chr11:48611651 C/T cg03929089 chr4:120376271 NA -0.47 -8.98 -0.33 2.9e-18 HDL cholesterol; BRCA cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg18230493 chr5:56204884 C5orf35 0.72 13.7 0.48 1.2e-37 Initial pursuit acceleration; BRCA cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.53 0.35 3.32e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs3733585 0.699 rs6449172 chr4:9966036 A/T cg26043149 chr18:55253948 FECH -0.38 -8.3 -0.31 6.34e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7301826 0.651 rs12228957 chr12:131296066 T/C cg11011512 chr12:131303247 STX2 0.52 13.65 0.48 2.18e-37 Plasma plasminogen activator levels; BRCA cis rs752010 0.806 rs6696511 chr1:42110888 T/C cg06885757 chr1:42089581 HIVEP3 0.31 10.11 0.37 2.16e-22 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs11690935 0.959 rs77280952 chr2:172620151 G/C cg13550731 chr2:172543902 DYNC1I2 -0.91 -29.23 -0.76 6.7e-120 Schizophrenia; BRCA cis rs7607369 0.572 rs629177 chr2:219454801 T/G cg10223061 chr2:219282414 VIL1 -0.27 -8.05 -0.3 4.05e-15 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs1973993 0.537 rs11165664 chr1:97001427 G/T cg10631902 chr5:14652156 NA -0.41 -10.19 -0.37 1.03e-22 Weight; BRCA cis rs4466137 0.953 rs1420654 chr5:82975793 G/A cg16102102 chr5:83017553 HAPLN1 -0.91 -17.92 -0.58 1.78e-58 Prostate cancer; BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg27170947 chr2:26402098 FAM59B 0.96 14.89 0.51 2.92e-43 Gut microbiome composition (summer); BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.33 -8.46 -0.32 1.81e-16 Total body bone mineral density; BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg05863683 chr7:1912471 MAD1L1 0.38 8.63 0.32 4.83e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs9309473 1.000 rs1403284 chr2:73726662 A/G cg20560298 chr2:73613845 ALMS1 0.46 11.37 0.41 2.07e-27 Metabolite levels; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg18402987 chr7:1209562 NA 0.9 14.07 0.49 2.31e-39 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg06671706 chr8:8559999 CLDN23 0.43 8.43 0.32 2.33e-16 Obesity-related traits; BRCA cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg20503657 chr10:835505 NA 0.61 10.38 0.38 1.89e-23 Eosinophil percentage of granulocytes; BRCA cis rs40363 0.645 rs1690447 chr16:3519211 T/C cg21433313 chr16:3507492 NAT15 0.42 8.63 0.32 4.99e-17 Tuberculosis; BRCA cis rs921968 0.541 rs514356 chr2:219375018 C/T cg02176678 chr2:219576539 TTLL4 0.45 11.73 0.42 6.24e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs7474896 0.526 rs1208716 chr10:38089273 T/A cg25427524 chr10:38739819 LOC399744 -0.53 -9.06 -0.34 1.57e-18 Obesity (extreme); BRCA cis rs2115630 1.000 rs58581703 chr15:85276935 C/T cg12863693 chr15:85201151 NMB -0.33 -7.93 -0.3 9.96e-15 P wave terminal force; BRCA cis rs453301 0.686 rs6601280 chr8:8909236 A/T cg06636001 chr8:8085503 FLJ10661 0.44 9.05 0.34 1.65e-18 Joint mobility (Beighton score); BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs9487051 0.676 rs9320278 chr6:109562589 T/C cg01475377 chr6:109611718 NA -0.37 -8.77 -0.33 1.65e-17 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg08280861 chr8:58055591 NA 0.54 8.85 0.33 8.57e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.863 rs10013305 chr4:120450424 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs7246657 0.663 rs4803276 chr19:38072330 C/A cg23950597 chr19:37808831 NA -0.51 -8.69 -0.33 3e-17 Coronary artery calcification; BRCA cis rs7586879 0.658 rs7563204 chr2:25125075 T/G cg04586622 chr2:25135609 ADCY3 0.46 11.61 0.42 2.11e-28 Body mass index; BRCA cis rs61931739 0.500 rs1843736 chr12:34012080 C/G cg06521331 chr12:34319734 NA -0.62 -11.25 -0.41 6.25e-27 Morning vs. evening chronotype; BRCA cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg13010199 chr12:38710504 ALG10B 0.5 9.95 0.37 8.54e-22 Bladder cancer; BRCA cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg23711669 chr6:146136114 FBXO30 0.74 15.38 0.52 1.27e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs2257809 chr20:25266476 C/T cg08601574 chr20:25228251 PYGB 0.35 8.43 0.32 2.33e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs78456975 0.527 rs10206020 chr2:1557927 A/G cg01028140 chr2:1542097 TPO -0.59 -12.55 -0.44 1.88e-32 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2549003 0.966 rs839 chr5:131819126 C/T cg02551604 chr5:131831745 NA -0.39 -14.68 -0.5 2.84e-42 Asthma (sex interaction); BRCA cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -8.15 -0.31 1.97e-15 Bipolar disorder; BRCA cis rs61931739 0.500 rs7309421 chr12:34553795 C/T cg06521331 chr12:34319734 NA -0.54 -9.8 -0.36 3.33e-21 Morning vs. evening chronotype; BRCA cis rs7772486 0.875 rs1412080 chr6:146417304 T/C cg23711669 chr6:146136114 FBXO30 0.67 15.63 0.53 7.19e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs7095944 0.614 rs12570348 chr10:126438963 A/C cg08799069 chr10:126477246 METTL10 0.37 8.59 0.32 6.56e-17 Asthma; BRCA cis rs3812049 0.784 rs2568928 chr5:127487603 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.56 -10.43 -0.38 1.21e-23 Lymphocyte counts;Red cell distribution width; BRCA cis rs9814567 0.964 rs9820425 chr3:134223018 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.41 -0.32 2.73e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg25204440 chr1:209979598 IRF6 0.42 8.52 0.32 1.16e-16 Cleft lip with or without cleft palate; BRCA cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.02 0.34 2.16e-18 Tonsillectomy; BRCA cis rs11051970 0.879 rs2467065 chr12:32586065 A/G cg02745156 chr12:32552066 NA 0.27 8.81 0.33 1.16e-17 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs881375 0.654 rs10760126 chr9:123662618 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 9.59 0.35 1.87e-20 Rheumatoid arthritis; BRCA cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg21918786 chr6:109611834 NA -0.44 -11.63 -0.42 1.73e-28 Reticulocyte fraction of red cells; BRCA cis rs2070488 0.965 rs6599209 chr3:38558197 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.7 -19.18 -0.6 3.96e-65 Electrocardiographic conduction measures; BRCA cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg14416726 chr6:151773293 C6orf211;RMND1 0.44 10.91 0.4 1.58e-25 Menarche (age at onset); BRCA cis rs9649213 0.593 rs6945554 chr7:97972946 T/C cg21770322 chr7:97807741 LMTK2 0.45 11.72 0.42 6.88e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6831352 0.918 rs7670241 chr4:100059619 G/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs16976116 0.851 rs28699327 chr15:55500335 A/G cg11288833 chr15:55489084 RSL24D1 0.48 10.68 0.39 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6429082 1.000 rs2055127 chr1:235598973 C/T cg26050004 chr1:235667680 B3GALNT2 -0.38 -9.05 -0.34 1.71e-18 Adiposity; BRCA cis rs2239547 0.603 rs17304995 chr3:53070755 A/G cg11645453 chr3:52864694 ITIH4 0.42 9.26 0.34 3.09e-19 Schizophrenia; BRCA cis rs3784262 1.000 rs4646640 chr15:58247563 C/G cg12031962 chr15:58353849 ALDH1A2 0.47 12.66 0.45 6.25e-33 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg06484146 chr7:12443880 VWDE -0.72 -9.94 -0.37 9.57e-22 Coronary artery disease; BRCA cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg18904891 chr8:8559673 CLDN23 0.66 13.18 0.46 2.92e-35 Obesity-related traits; BRCA cis rs12540874 0.931 rs4245555 chr7:50661409 A/G cg18232548 chr7:50535776 DDC -0.36 -7.9 -0.3 1.26e-14 Systemic sclerosis; BRCA cis rs7809950 0.817 rs34325395 chr7:107113808 C/G cg23024343 chr7:107201750 COG5 -0.53 -10.99 -0.4 7.39e-26 Coronary artery disease; BRCA cis rs1348850 0.519 rs4144275 chr2:178523368 C/T cg22681709 chr2:178499509 PDE11A -0.38 -8.24 -0.31 9.86e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs36051895 0.626 rs12349785 chr9:5076613 G/C cg02405213 chr9:5042618 JAK2 -0.55 -9.84 -0.36 2.32e-21 Pediatric autoimmune diseases; BRCA cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg20607287 chr7:12443886 VWDE -0.58 -8.5 -0.32 1.36e-16 Coronary artery disease; BRCA cis rs9875589 0.509 rs9836573 chr3:14065239 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.97 0.33 3.39e-18 Ovarian reserve; BRCA cis rs7666738 0.830 rs28465658 chr4:99035866 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4930561 1.000 rs4930561 chr11:67931761 C/T cg04465784 chr11:67976953 SUV420H1 -0.24 -8.09 -0.3 3e-15 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs1691799 0.806 rs1168319 chr12:66744857 T/A cg16791601 chr12:66731901 HELB -0.69 -19.67 -0.61 1.03e-67 White blood cell count (basophil); BRCA cis rs10464366 0.957 rs6979210 chr7:39104119 C/G cg18850127 chr7:39170497 POU6F2 0.39 8.26 0.31 8.58e-16 IgG glycosylation; BRCA cis rs9300255 0.722 rs10846515 chr12:123801672 T/G cg00376283 chr12:123451042 ABCB9 0.49 11.23 0.41 8.03e-27 Neutrophil percentage of white cells; BRCA cis rs1499972 0.941 rs62263112 chr3:117615515 T/C cg07612923 chr3:117604196 NA 0.59 7.96 0.3 7.85e-15 Schizophrenia; BRCA cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg13393036 chr8:95962371 TP53INP1 -0.3 -8.06 -0.3 3.7e-15 Type 2 diabetes; BRCA cis rs2414095 0.527 rs35241865 chr15:51541301 C/T cg19946085 chr15:51559439 CYP19A1 -0.3 -7.92 -0.3 1.06e-14 Follicule stimulating hormone;Hormone measurements;Total body bone mineral density; BRCA cis rs778371 0.723 rs1078323 chr2:233681512 T/G cg08000102 chr2:233561755 GIGYF2 -0.74 -17.03 -0.56 6.87e-54 Schizophrenia; BRCA cis rs939658 0.683 rs11634726 chr15:79465894 A/G cg17916960 chr15:79447300 NA -0.37 -9.21 -0.34 4.68e-19 Refractive error; BRCA cis rs875971 0.658 rs432667 chr7:65514633 A/G cg11764359 chr7:65958608 NA 0.76 17.54 0.57 1.67e-56 Aortic root size; BRCA cis rs6831352 0.877 rs29001183 chr4:100056539 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7523273 0.586 rs2796276 chr1:207951513 G/A cg22525895 chr1:207977042 MIR29B2 0.48 12.09 0.43 1.96e-30 Schizophrenia; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg04267008 chr7:1944627 MAD1L1 -0.49 -10.99 -0.4 7.77e-26 Bipolar disorder and schizophrenia; BRCA cis rs877529 0.627 rs139426 chr22:39560666 C/T cg12193277 chr22:39547181 CBX7 0.38 8.91 0.33 5.28e-18 Multiple myeloma; BRCA trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg15704280 chr7:45808275 SEPT13 0.82 19.68 0.61 8.74e-68 Height; BRCA cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg21644426 chr2:191273491 MFSD6 0.45 11.47 0.41 8.3e-28 Pulse pressure; BRCA cis rs6598955 0.617 rs11247895 chr1:26599542 G/A cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs4953318 0.619 rs13406901 chr2:46363066 T/G cg12428440 chr2:46370979 PRKCE 0.49 10.67 0.39 1.44e-24 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg18876405 chr7:65276391 NA 0.48 10.77 0.39 5.57e-25 Aortic root size; BRCA cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.935 rs13156002 chr5:93508931 G/A cg21475434 chr5:93447410 FAM172A 0.69 8.96 0.33 3.44e-18 Diabetic retinopathy; BRCA cis rs10496034 1.000 rs4672006 chr2:55251511 C/G cg16098955 chr2:55172992 EML6 0.53 8.81 0.33 1.17e-17 Refractive astigmatism; BRCA cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs1499972 0.941 rs62263121 chr3:117630348 T/C cg07612923 chr3:117604196 NA 0.6 8.15 0.31 1.97e-15 Schizophrenia; BRCA cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg06636001 chr8:8085503 FLJ10661 -0.51 -11.15 -0.4 1.67e-26 Neuroticism; BRCA cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg08355456 chr11:67383691 NA -0.42 -8.48 -0.32 1.55e-16 Mean corpuscular volume; BRCA cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg06697600 chr4:7070879 GRPEL1 -0.55 -10.62 -0.39 2.27e-24 Monocyte percentage of white cells; BRCA cis rs2625529 0.526 rs8040828 chr15:72492779 C/A cg16672083 chr15:72433130 SENP8 0.65 15.59 0.52 1.13e-46 Red blood cell count; BRCA cis rs35146811 0.735 rs1061230 chr7:99807265 G/A cg13334819 chr7:99746414 C7orf59 0.35 8.26 0.31 8.17e-16 Coronary artery disease; BRCA cis rs2832191 0.791 rs57721945 chr21:30498744 T/C cg08807101 chr21:30365312 RNF160 -0.59 -14.68 -0.5 3.1e-42 Dental caries; BRCA cis rs9790314 0.934 rs455386 chr3:161102495 A/T cg04691961 chr3:161091175 C3orf57 -0.53 -12.27 -0.44 3.14e-31 Morning vs. evening chronotype; BRCA cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11644478 chr21:40555479 PSMG1 0.77 16.75 0.55 1.81e-52 Cognitive function; BRCA cis rs10754283 0.967 rs4658307 chr1:90117586 G/T cg21401794 chr1:90099060 LRRC8C 0.5 12.05 0.43 2.76e-30 Amyotrophic lateral sclerosis (sporadic); BRCA trans rs877282 0.583 rs11253441 chr10:828288 C/T cg22713356 chr15:30763199 NA -1.01 -16.1 -0.54 3.23e-49 Uric acid levels; BRCA cis rs312273 0.682 rs1442188 chr12:41342928 A/T cg17827154 chr12:41323612 CNTN1 -0.42 -10.99 -0.4 7.79e-26 Bipolar disorder; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg18404041 chr3:52824283 ITIH1 -0.32 -9.55 -0.35 2.67e-20 Bipolar disorder; BRCA trans rs61931739 0.534 rs10844791 chr12:34211659 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.58 0.35 2.14e-20 Morning vs. evening chronotype; BRCA trans rs2018683 0.835 rs7782264 chr7:28978986 A/G cg19402173 chr7:128379420 CALU 0.46 11.3 0.41 4.14e-27 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs858239 0.965 rs156429 chr7:23306020 A/G cg23682824 chr7:23144976 KLHL7 0.39 9.54 0.35 2.92e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg06212747 chr3:49208901 KLHDC8B 0.51 10.72 0.39 9.42e-25 Parkinson's disease; BRCA cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg00074818 chr8:8560427 CLDN23 0.38 8.35 0.31 4.32e-16 Obesity-related traits; BRCA trans rs62103177 0.810 rs62103197 chr18:77632923 G/A cg05926928 chr17:57297772 GDPD1 1.43 18.2 0.58 5.7e-60 Opioid sensitivity; BRCA cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg06784218 chr1:46089804 CCDC17 0.49 11.73 0.42 6.43e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs9291683 0.552 rs10939656 chr4:10014646 A/C cg26043149 chr18:55253948 FECH 0.4 8.64 0.32 4.54e-17 Bone mineral density; BRCA cis rs921968 0.643 rs492400 chr2:219349752 C/T cg02176678 chr2:219576539 TTLL4 0.36 9.45 0.35 6.13e-20 Mean corpuscular hemoglobin concentration; BRCA cis rs7100689 0.646 rs10466235 chr10:82149655 C/T cg01528321 chr10:82214614 TSPAN14 -0.82 -18.72 -0.6 1.15e-62 Post bronchodilator FEV1; BRCA cis rs1005277 0.579 rs2472173 chr10:38374638 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -11.19 -0.4 1.19e-26 Extrinsic epigenetic age acceleration; BRCA cis rs9814567 1.000 rs1814336 chr3:134200823 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.26 -0.61 1.53e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg11584989 chr19:19387371 SF4 0.63 13.4 0.47 2.87e-36 Bipolar disorder; BRCA cis rs7927592 0.871 rs17603185 chr11:68376241 C/T cg20283391 chr11:68216788 NA -0.46 -9.32 -0.35 1.9e-19 Total body bone mineral density; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg02951883 chr7:2050386 MAD1L1 -0.61 -15.14 -0.51 1.71e-44 Bipolar disorder and schizophrenia; BRCA cis rs898097 0.625 rs898095 chr17:80890638 T/C cg15664640 chr17:80829946 TBCD 0.41 10.96 0.4 9.79e-26 Breast cancer; BRCA cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg12386194 chr3:101231763 SENP7 0.45 9.1 0.34 1.16e-18 Colorectal cancer; BRCA trans rs11098499 0.954 rs10014845 chr4:120301077 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.61 -0.65 3.9e-78 Intelligence (multi-trait analysis); BRCA cis rs7085104 0.513 rs192569 chr10:104577915 T/C cg04362960 chr10:104952993 NT5C2 -0.34 -7.97 -0.3 7.15e-15 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg04518342 chr5:131593106 PDLIM4 0.37 9.45 0.35 6.26e-20 Breast cancer; BRCA cis rs4891159 0.513 rs2554831 chr18:74113513 C/G cg24786174 chr18:74118243 ZNF516 0.81 23.38 0.68 7.66e-88 Longevity; BRCA cis rs593982 0.843 rs552312 chr11:65477349 C/T cg08755490 chr11:65554678 OVOL1 1.21 17.62 0.57 6.01e-57 Atopic dermatitis; BRCA cis rs6714710 0.603 rs13008968 chr2:98435982 C/T cg26665480 chr2:98280029 ACTR1B 0.58 13.65 0.48 1.99e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1011018 0.590 rs10278124 chr7:139416939 C/G cg03224163 chr7:139420300 HIPK2 -0.55 -9.01 -0.34 2.39e-18 Systolic blood pressure; BRCA cis rs1003719 0.680 rs2835620 chr21:38505581 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg03433033 chr1:76189801 ACADM 0.59 11.29 0.41 4.47e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3806843 0.900 rs116210441 chr5:140128649 T/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.23 0.34 4.05e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg09455208 chr3:40491958 NA -0.49 -11.88 -0.43 1.43e-29 Renal cell carcinoma; BRCA cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg23583168 chr7:148888333 NA -0.86 -20.12 -0.62 4.07e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA trans rs61931739 0.517 rs9668303 chr12:34366701 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.4 0.35 9.9e-20 Morning vs. evening chronotype; BRCA cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg09580153 chr6:41068724 NFYA;LOC221442 0.39 9.03 0.34 2.01e-18 Alzheimer's disease (late onset); BRCA cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg08975724 chr8:8085496 FLJ10661 0.39 8.24 0.31 9.6e-16 Neuroticism; BRCA cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.38 0.31 3.45e-16 Multiple sclerosis; BRCA trans rs6582630 0.555 rs10880625 chr12:38526612 A/C cg06521331 chr12:34319734 NA -0.51 -9.39 -0.35 1.01e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs941873 0.868 rs7332 chr10:81114060 G/A cg11057378 chr10:81107060 PPIF 0.43 10.22 0.37 8.19e-23 Height; BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg04944784 chr2:26401820 FAM59B -1.01 -16.9 -0.56 3.04e-53 Gut microbiome composition (summer); BRCA cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg25174290 chr11:3078921 CARS 0.45 13.55 0.47 6.13e-37 Longevity; BRCA cis rs1707322 0.963 rs4630155 chr1:46257110 G/C cg06784218 chr1:46089804 CCDC17 0.49 11.58 0.42 2.67e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg10494973 chr17:80897199 TBCD -0.36 -8.27 -0.31 7.87e-16 Breast cancer; BRCA cis rs870825 0.616 rs9631783 chr4:185626511 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7809950 0.593 rs62482503 chr7:106987988 A/G cg23024343 chr7:107201750 COG5 -0.46 -9.48 -0.35 4.74e-20 Coronary artery disease; BRCA cis rs9287719 0.967 rs6759740 chr2:10747271 A/G cg00105475 chr2:10696890 NA 0.44 10.4 0.38 1.66e-23 Prostate cancer; BRCA cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg12591125 chr7:1885375 MAD1L1 0.5 8.81 0.33 1.2e-17 Bipolar disorder; BRCA cis rs6598955 0.543 rs3795689 chr1:26560366 C/G cg12744634 chr1:26560303 CCDC21 0.31 8.7 0.33 2.81e-17 Obesity-related traits; BRCA cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg04166393 chr7:2884313 GNA12 0.41 8.46 0.32 1.86e-16 Height; BRCA cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.29 -0.31 6.7e-16 Colorectal cancer; BRCA cis rs12579753 0.917 rs12822036 chr12:82183009 C/T cg07988820 chr12:82153109 PPFIA2 -0.49 -8.57 -0.32 7.78e-17 Resting heart rate; BRCA cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg19077165 chr18:44547161 KATNAL2 0.55 12.19 0.43 6.77e-31 Personality dimensions; BRCA cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg23711669 chr6:146136114 FBXO30 0.77 17.91 0.58 1.88e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs2019216 0.872 rs6565384 chr17:21897456 T/C cg22648282 chr17:21454238 C17orf51 -0.35 -8.07 -0.3 3.53e-15 Pelvic organ prolapse; BRCA cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg18876405 chr7:65276391 NA -0.51 -11.43 -0.41 1.12e-27 Aortic root size; BRCA cis rs7267979 0.932 rs446649 chr20:25467359 A/G cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.64e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6743226 0.901 rs4675968 chr2:242222492 T/C cg10021735 chr2:242295487 FARP2 0.36 9.85 0.36 2.03e-21 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg03923535 chr7:1197113 ZFAND2A 0.53 10.64 0.39 1.83e-24 Longevity;Endometriosis; BRCA cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg01884057 chr2:25150051 NA 0.34 9.04 0.34 1.88e-18 Body mass index; BRCA cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg17971929 chr21:40555470 PSMG1 -0.61 -13.51 -0.47 9.06e-37 Cognitive function; BRCA cis rs7474896 0.526 rs1742235 chr10:38052256 T/C cg25427524 chr10:38739819 LOC399744 -0.54 -9.73 -0.36 6.02e-21 Obesity (extreme); BRCA cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.78 0.33 1.45e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17604090 0.793 rs17150665 chr7:29688860 T/G cg19413766 chr7:29689036 LOC646762 -0.51 -8.2 -0.31 1.33e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs9296092 0.517 rs62405949 chr6:33522800 G/A cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7586879 0.638 rs13035244 chr2:25134009 T/C cg01884057 chr2:25150051 NA 0.34 8.98 0.33 3.03e-18 Body mass index; BRCA cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg12893428 chr3:195717962 SDHAP1 0.34 8.33 0.31 4.77e-16 Pancreatic cancer; BRCA cis rs4363385 0.818 rs3806223 chr1:153002646 T/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.81 -0.33 1.17e-17 Inflammatory skin disease; BRCA cis rs4664304 0.620 rs2048436 chr2:160712119 A/G cg14819504 chr2:160761413 LY75 0.34 8.5 0.32 1.38e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2836974 0.836 rs1041440 chr21:40627325 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.57 0.59 7.02e-62 Cognitive function; BRCA cis rs524281 0.861 rs2293121 chr11:65961347 T/G cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4e-15 Electroencephalogram traits; BRCA cis rs290268 0.874 rs290997 chr9:93559351 G/A cg02608019 chr9:93564028 SYK 0.56 12.3 0.44 2.4e-31 Platelet count; BRCA cis rs1997103 1.000 rs12718956 chr7:55407763 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6964587 1.000 rs10236397 chr7:91691601 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg03264133 chr6:25882463 NA -0.51 -10.46 -0.38 9.67e-24 Intelligence (multi-trait analysis); BRCA cis rs586533 0.881 rs7935457 chr11:99512337 C/T cg22878054 chr11:99397252 CNTN5 -0.31 -7.83 -0.3 2.06e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg26513180 chr16:89883248 FANCA -0.72 -18.33 -0.59 1.33e-60 Vitiligo; BRCA cis rs10463316 0.894 rs4099168 chr5:150766467 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.17e-16 Metabolite levels (Pyroglutamine); BRCA cis rs13006833 0.668 rs2582746 chr2:191163784 T/C cg21644426 chr2:191273491 MFSD6 0.32 7.83 0.3 2.06e-14 Urinary metabolites; BRCA cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.82 0.33 1.11e-17 Bladder cancer; BRCA cis rs61931739 0.500 rs7965421 chr12:34523624 G/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs6977660 0.714 rs13230381 chr7:19833896 T/C cg05791153 chr7:19748676 TWISTNB 0.58 10.74 0.39 7.76e-25 Thyroid stimulating hormone; BRCA cis rs1707322 0.821 rs10749857 chr1:46248143 C/T cg03146154 chr1:46216737 IPP 0.52 11.44 0.41 1.1e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7572733 0.534 rs1436131 chr2:198731230 A/C cg00792783 chr2:198669748 PLCL1 0.46 10.08 0.37 2.93e-22 Dermatomyositis; BRCA cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03517284 chr6:25882590 NA -0.62 -13.63 -0.47 2.59e-37 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.78 -0.58 9.4e-58 Chronic sinus infection; BRCA trans rs17685 0.523 rs10246583 chr7:75746667 C/A cg19862616 chr7:65841803 NCRNA00174 0.84 27.93 0.74 8.11e-113 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6450176 1.000 rs10805455 chr5:53302302 T/G ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs12711979 0.566 rs6706842 chr2:3853962 G/C cg17052675 chr2:3827356 NA -0.34 -8.21 -0.31 1.24e-15 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs778371 0.659 rs2289911 chr2:233704252 A/G cg08000102 chr2:233561755 GIGYF2 -0.77 -16.67 -0.55 4.68e-52 Schizophrenia; BRCA trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg03929089 chr4:120376271 NA -0.44 -8.83 -0.33 1.03e-17 Coronary artery disease; BRCA trans rs7181230 0.885 rs9919974 chr15:40337462 T/G cg22705835 chr10:65332833 REEP3 -0.43 -9.3 -0.35 2.24e-19 Dehydroepiandrosterone sulphate levels; BRCA cis rs62380364 0.558 rs34319 chr5:88023349 A/T cg22951263 chr5:87985283 NA -0.38 -10.66 -0.39 1.57e-24 Intelligence (multi-trait analysis); BRCA cis rs7903847 0.619 rs10786336 chr10:99134953 A/C cg20016023 chr10:99160130 RRP12 -0.27 -8.67 -0.32 3.62e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs9837602 1.000 rs4571265 chr3:99705111 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -11.28 -0.41 4.85e-27 Breast cancer; BRCA cis rs9467711 0.591 rs13192365 chr6:25993968 T/C cg08501292 chr6:25962987 TRIM38 0.59 8.02 0.3 4.97e-15 Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg26384229 chr12:38710491 ALG10B 0.74 16.55 0.55 1.74e-51 Morning vs. evening chronotype; BRCA cis rs11098499 0.874 rs6822498 chr4:120120183 T/C cg09307838 chr4:120376055 NA 0.61 11.22 0.41 8.68e-27 Corneal astigmatism; BRCA trans rs9329221 0.576 rs1986972 chr8:10268805 C/T cg06636001 chr8:8085503 FLJ10661 0.48 9.21 0.34 4.48e-19 Neuroticism; BRCA cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg26373071 chr5:1325741 CLPTM1L -0.5 -12.3 -0.44 2.24e-31 Lung cancer; BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg26314531 chr2:26401878 FAM59B 0.95 16.32 0.54 2.59e-50 Mean corpuscular hemoglobin; BRCA cis rs9814567 0.964 rs4974480 chr3:134178562 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.53 -0.57 1.87e-56 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg13298116 chr11:62369859 EML3;MTA2 0.56 13.48 0.47 1.31e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs7613875 0.600 rs7061 chr3:50114515 C/T cg21659725 chr3:3221576 CRBN -0.34 -7.91 -0.3 1.13e-14 Body mass index; BRCA trans rs12517041 1.000 rs1428625 chr5:23290664 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs1997103 1.000 rs6593238 chr7:55411048 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7707921 0.505 rs12516434 chr5:81428072 T/A cg15871215 chr5:81402204 ATG10 0.39 9.17 0.34 6.27e-19 Breast cancer; BRCA trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.89 -0.3 1.27e-14 Corneal astigmatism; BRCA cis rs2204008 0.807 rs8186948 chr12:38325101 C/G cg26384229 chr12:38710491 ALG10B 0.69 16.03 0.54 7.2e-49 Bladder cancer; BRCA cis rs1030877 0.960 rs3792047 chr2:105901553 A/G cg02079111 chr2:105885981 TGFBRAP1 -0.65 -15.43 -0.52 6.96e-46 Obesity-related traits; BRCA cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg19622623 chr12:86230825 RASSF9 -0.29 -8.11 -0.31 2.57e-15 Major depressive disorder; BRCA cis rs921968 0.509 rs626432 chr2:219355658 C/A cg02176678 chr2:219576539 TTLL4 0.46 11.82 0.42 2.72e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg23029597 chr12:123009494 RSRC2 -0.63 -12.61 -0.45 1.06e-32 Body mass index; BRCA cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg20701182 chr2:24300061 SF3B14 0.56 8.61 0.32 5.89e-17 Lymphocyte counts; BRCA cis rs73242632 1.000 rs41344750 chr4:57830213 C/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.65 8.15 0.31 1.97e-15 Congenital heart disease (maternal effect); BRCA cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg26597838 chr10:835615 NA 1.3 21.86 0.65 1.6e-79 Eosinophil percentage of granulocytes; BRCA cis rs11252926 0.966 rs61831030 chr10:578869 C/T cg18196295 chr10:418757 DIP2C -0.46 -9.35 -0.35 1.5e-19 Psychosis in Alzheimer's disease; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg14196790 chr5:131705035 SLC22A5 0.35 9.18 0.34 5.93e-19 Breast cancer; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg16145915 chr7:1198662 ZFAND2A -0.69 -19.25 -0.61 1.86e-65 Longevity;Endometriosis; BRCA cis rs9467773 1.000 rs10484442 chr6:26555879 A/G cg09904177 chr6:26538194 HMGN4 0.55 17.64 0.57 4.63e-57 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.545 rs12828790 chr12:39401043 G/A cg26384229 chr12:38710491 ALG10B 0.49 10.72 0.39 8.69e-25 Morning vs. evening chronotype; BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg04267008 chr7:1944627 MAD1L1 -0.49 -11.06 -0.4 3.97e-26 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.44 0.57 5.18e-56 Platelet count; BRCA cis rs4800452 1.000 rs4800452 chr18:20727611 C/T cg26136497 chr18:20735537 CABLES1 -0.41 -10.4 -0.38 1.68e-23 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg08975724 chr8:8085496 FLJ10661 0.49 10.51 0.38 6.04e-24 Mood instability; BRCA cis rs826838 0.586 rs1843903 chr12:38627524 C/T cg26384229 chr12:38710491 ALG10B 0.48 11.27 0.41 5.27e-27 Heart rate; BRCA cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg20701182 chr2:24300061 SF3B14 0.51 8.65 0.32 4.27e-17 Lymphocyte counts; BRCA cis rs6547741 1.000 rs1972669 chr2:27767107 T/G cg27432699 chr2:27873401 GPN1 0.47 9.94 0.37 9.8e-22 Oral cavity cancer; BRCA cis rs61931739 0.500 rs11053274 chr12:34547605 G/A cg06521331 chr12:34319734 NA -0.57 -10.33 -0.38 3.02e-23 Morning vs. evening chronotype; BRCA cis rs4074536 0.536 rs10754353 chr1:116292387 C/T cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 4.94e-17 QRS duration; BRCA cis rs7520050 0.778 rs3014238 chr1:46090214 A/G cg24296786 chr1:45957014 TESK2 0.45 10.21 0.37 9.1e-23 Red blood cell count;Reticulocyte count; BRCA trans rs11165623 0.564 rs6593612 chr1:97002041 C/A cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.18e-30 Hip circumference;Waist circumference; BRCA cis rs7586673 0.964 rs34444368 chr2:161954217 G/A cg16506815 chr2:162101123 NA 0.47 9.69 0.36 8.46e-21 Intelligence (multi-trait analysis); BRCA cis rs636291 0.517 rs670666 chr1:10549380 C/T cg17425144 chr1:10567563 PEX14 -0.56 -14.37 -0.49 8.57e-41 Prostate cancer; BRCA cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.97 -0.33 3.32e-18 Bipolar disorder; BRCA cis rs4727027 0.901 rs12671341 chr7:148805282 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.6 0.39 2.82e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs16854884 0.632 rs1910691 chr3:143656905 G/A cg06585982 chr3:143692056 C3orf58 0.44 8.95 0.33 3.97e-18 Economic and political preferences (feminism/equality); BRCA cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.05 0.46 1.08e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11608355 0.545 rs4766475 chr12:109908373 G/A cg05360138 chr12:110035743 NA 0.71 13.09 0.46 7.36e-35 Neuroticism; BRCA cis rs769267 1.000 rs769267 chr19:19446936 A/G cg03709012 chr19:19516395 GATAD2A 0.75 16.86 0.55 4.87e-53 Tonsillectomy; BRCA cis rs2243480 0.708 rs35825036 chr7:65986502 T/C cg18252515 chr7:66147081 NA -1.06 -15.85 -0.53 6.1e-48 Diabetic kidney disease; BRCA cis rs644148 0.836 rs2686770 chr19:44998773 A/G cg15540054 chr19:45004280 ZNF180 -0.55 -12.04 -0.43 3.15e-30 Personality dimensions; BRCA cis rs9818758 0.607 rs56004653 chr3:49072228 T/C cg00383909 chr3:49044727 WDR6 0.96 13.41 0.47 2.68e-36 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs4363385 0.765 rs1094409 chr1:153021040 T/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.4 -0.32 2.92e-16 Inflammatory skin disease; BRCA cis rs6456156 0.586 rs12213683 chr6:167460718 G/A cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.68e-21 Primary biliary cholangitis; BRCA cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg23649088 chr2:200775458 C2orf69 0.57 8.47 0.32 1.67e-16 Schizophrenia; BRCA trans rs3960554 0.867 rs79359354 chr7:75702597 G/A cg19862616 chr7:65841803 NCRNA00174 0.56 12.08 0.43 2.11e-30 Eotaxin levels; BRCA cis rs9815354 0.812 rs4547673 chr3:41952303 A/C cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2422052 0.766 rs1583330 chr2:118650028 T/C cg22545206 chr2:118617499 NA 0.4 9.83 0.36 2.56e-21 Mosquito bite size; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.37e-16 Total body bone mineral density; BRCA cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg22117172 chr7:91764530 CYP51A1 0.23 7.88 0.3 1.46e-14 Breast cancer; BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -11.43 -0.41 1.17e-27 Alzheimer's disease; BRCA cis rs8072100 1.000 rs11870935 chr17:45732605 G/A cg25173405 chr17:45401733 C17orf57 0.52 11.12 0.4 2.15e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg23283495 chr1:209979779 IRF6 0.37 8.81 0.33 1.16e-17 Cleft lip with or without cleft palate; BRCA cis rs965469 1.000 rs6051715 chr20:3266548 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -10.19 -0.37 1.08e-22 IFN-related cytopenia; BRCA cis rs8114671 0.740 rs3761141 chr20:33737824 A/C cg24642439 chr20:33292090 TP53INP2 0.42 8.89 0.33 6.39e-18 Height; BRCA cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg07520158 chr7:32535189 LSM5;AVL9 -0.45 -8.77 -0.33 1.65e-17 Cognitive ability; BRCA trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21659725 chr3:3221576 CRBN 0.66 19.26 0.61 1.65e-65 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg22875332 chr1:76189707 ACADM 0.66 15.74 0.53 2.04e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg04267008 chr7:1944627 MAD1L1 -0.48 -10.15 -0.37 1.46e-22 Schizophrenia; BRCA cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.81 0.51 6.76e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs7677751 0.806 rs7673984 chr4:55088761 C/T cg17187183 chr4:55093834 PDGFRA 0.45 8.65 0.32 4.21e-17 Corneal astigmatism; BRCA cis rs7586879 0.929 rs6545807 chr2:25124358 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.24 0.34 3.73e-19 Body mass index; BRCA cis rs6484504 0.576 rs208093 chr11:31184400 C/T cg06552810 chr11:31128660 NA 0.39 8.74 0.33 2.01e-17 Red blood cell count; BRCA cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg26597838 chr10:835615 NA 0.62 10.45 0.38 1.09e-23 Eosinophil percentage of granulocytes; BRCA cis rs11105298 0.891 rs10858896 chr12:89920184 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.6 -0.36 1.76e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6977660 0.714 rs12386623 chr7:19791875 A/G cg07541023 chr7:19748670 TWISTNB -0.57 -9.86 -0.36 1.97e-21 Thyroid stimulating hormone; BRCA cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg02574844 chr11:5959923 NA -0.38 -7.94 -0.3 9.09e-15 DNA methylation (variation); BRCA cis rs2180341 1.000 rs2144742 chr6:127595786 C/A cg24812749 chr6:127587940 RNF146 0.86 20.21 0.62 1.41e-70 Breast cancer; BRCA cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg24642439 chr20:33292090 TP53INP2 0.54 11.71 0.42 7.92e-29 Glomerular filtration rate (creatinine); BRCA trans rs9325144 0.600 rs12227663 chr12:38734922 C/T cg23762105 chr12:34175262 ALG10 0.37 8.53 0.32 1.1e-16 Morning vs. evening chronotype; BRCA cis rs2243480 0.901 rs778730 chr7:65823325 T/A cg18252515 chr7:66147081 NA -1.06 -15.68 -0.53 3.88e-47 Diabetic kidney disease; BRCA cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22496380 chr5:211416 CCDC127 -0.99 -14.31 -0.49 1.63e-40 Breast cancer; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.21 -0.54 9.83e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg08999081 chr20:33150536 PIGU -0.45 -12.2 -0.43 6.33e-31 Glomerular filtration rate (creatinine); BRCA cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.79 -0.33 1.43e-17 Reticulocyte count; BRCA cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.95 0.3 8.36e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1003719 0.688 rs2000416 chr21:38540089 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -13.71 -0.48 1.05e-37 Eye color traits; BRCA cis rs6088813 1.000 rs2425065 chr20:33926268 A/T cg14752227 chr20:34000481 UQCC 0.41 8.85 0.33 8.24e-18 Height; BRCA cis rs514406 0.644 rs928451 chr1:53195800 A/G cg16325326 chr1:53192061 ZYG11B -0.95 -26.1 -0.72 8.67e-103 Monocyte count; BRCA cis rs1215050 0.791 rs1727278 chr4:98853576 A/G cg05340658 chr4:99064831 C4orf37 -0.43 -9.8 -0.36 3.27e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg18225595 chr11:63971243 STIP1 0.4 10.2 0.37 1.02e-22 Platelet count; BRCA cis rs6752107 1.000 rs12994997 chr2:234173503 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.54 0.42 4.13e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg05234568 chr11:5960015 NA -0.45 -9.33 -0.35 1.73e-19 DNA methylation (variation); BRCA cis rs2832191 0.692 rs2254872 chr21:30414724 C/T cg24692254 chr21:30365293 RNF160 0.78 21.27 0.64 2.52e-76 Dental caries; BRCA cis rs17095355 1.000 rs11194924 chr10:111695773 G/C cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.06 -0.37 3.42e-22 Biliary atresia; BRCA cis rs3820928 1.000 rs7592387 chr2:227777095 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.8e-16 Pulmonary function; BRCA cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg21770322 chr7:97807741 LMTK2 0.41 10.96 0.4 1.02e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg06115741 chr20:33292138 TP53INP2 0.4 8.82 0.33 1.07e-17 Coronary artery disease; BRCA cis rs9768139 0.733 rs56205111 chr7:158121055 T/C cg24154853 chr7:158122151 PTPRN2 0.34 7.91 0.3 1.12e-14 Calcium levels; BRCA cis rs11098499 0.863 rs12502389 chr4:120454191 A/G cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.63 -0.36 1.42e-20 Menopause (age at onset); BRCA cis rs9381040 0.610 rs6919961 chr6:41020361 T/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.19 -0.37 1.07e-22 Alzheimer's disease (late onset); BRCA cis rs477692 0.647 rs11016853 chr10:131443990 A/G cg05714579 chr10:131428358 MGMT -0.66 -16.54 -0.55 2.15e-51 Response to temozolomide; BRCA cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg18904891 chr8:8559673 CLDN23 0.61 12.04 0.43 3.06e-30 Obesity-related traits; BRCA cis rs7124681 0.546 rs7941399 chr11:47890421 A/T cg20307385 chr11:47447363 PSMC3 0.41 9.44 0.35 6.57e-20 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg24675658 chr1:53192096 ZYG11B 0.56 12.76 0.45 2.24e-33 Monocyte count; BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg22800045 chr5:56110881 MAP3K1 0.66 12.37 0.44 1.22e-31 Initial pursuit acceleration; BRCA cis rs6750047 0.771 rs1056837 chr2:38298150 A/G cg07380506 chr2:38303506 CYP1B1 0.52 12.67 0.45 5.8e-33 Cutaneous malignant melanoma;Melanoma; BRCA cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg22764044 chr5:178986830 RUFY1 0.36 8.55 0.32 8.92e-17 Lung cancer; BRCA cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg01119278 chr6:110721349 DDO -0.42 -10.25 -0.38 6.5e-23 Platelet distribution width; BRCA cis rs1506636 1.000 rs2299984 chr7:123356921 G/T cg03229431 chr7:123269106 ASB15 0.61 13.74 0.48 7.93e-38 Plateletcrit;Platelet count; BRCA cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg11764359 chr7:65958608 NA -0.77 -17.3 -0.56 2.66e-55 Aortic root size; BRCA cis rs765787 0.530 rs12903149 chr15:45539076 G/A cg25801113 chr15:45476975 SHF -0.34 -8.14 -0.31 2.01e-15 Uric acid levels; BRCA cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.4 0.57 8.7e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg21095983 chr6:86352623 SYNCRIP 0.45 9.87 0.36 1.74e-21 Smooth-surface caries; BRCA cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg06115741 chr20:33292138 TP53INP2 0.49 11.05 0.4 4.27e-26 Coronary artery disease; BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg13047869 chr3:10149882 C3orf24 0.53 11.24 0.41 6.83e-27 Alzheimer's disease; BRCA cis rs9325144 0.555 rs4882359 chr12:38726679 T/C cg26384229 chr12:38710491 ALG10B 0.48 12.29 0.44 2.61e-31 Morning vs. evening chronotype; BRCA cis rs13191362 1.000 rs34066731 chr6:163011047 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12618769 0.652 rs3754871 chr2:99224309 A/T cg10123293 chr2:99228465 UNC50 0.43 8.6 0.32 6.35e-17 Bipolar disorder; BRCA cis rs12210905 0.688 rs12212632 chr6:27472416 T/C cg08851530 chr6:28072375 NA 0.81 8.01 0.3 5.53e-15 Hip circumference adjusted for BMI; BRCA cis rs3760982 0.585 rs62116964 chr19:44291986 T/C cg11993925 chr19:44307056 LYPD5 0.38 8.95 0.33 3.73e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg11941060 chr3:133502564 NA -0.39 -8.81 -0.33 1.21e-17 Iron status biomarkers; BRCA cis rs965469 1.000 rs6037583 chr20:3360632 G/A cg25506879 chr20:3388711 C20orf194 -0.52 -10.32 -0.38 3.25e-23 IFN-related cytopenia; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26314531 chr2:26401878 FAM59B -0.96 -16.62 -0.55 8.34e-52 Gut microbiome composition (summer); BRCA cis rs10751667 0.643 rs7396623 chr11:934104 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.71 0.55 2.87e-52 Alzheimer's disease (late onset); BRCA cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg20307385 chr11:47447363 PSMC3 0.4 8.4 0.32 2.82e-16 Subjective well-being; BRCA cis rs3857067 0.806 rs72665608 chr4:95093501 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.44 -0.35 6.72e-20 QT interval; BRCA cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.7 0.36 7.91e-21 Menopause (age at onset); BRCA trans rs7824557 0.767 rs2164272 chr8:11162496 A/C cg15556689 chr8:8085844 FLJ10661 0.37 8.71 0.33 2.66e-17 Retinal vascular caliber; BRCA cis rs12497850 0.805 rs11130176 chr3:48844077 A/G cg06212747 chr3:49208901 KLHDC8B 0.47 9.64 0.36 1.24e-20 Parkinson's disease; BRCA cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg04586622 chr2:25135609 ADCY3 0.46 11.51 0.41 5.31e-28 Body mass index; BRCA cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg06640241 chr16:89574553 SPG7 0.58 12.73 0.45 2.99e-33 Multiple myeloma (IgH translocation); BRCA cis rs7824557 0.606 rs2736273 chr8:11199938 C/A cg21775007 chr8:11205619 TDH 0.71 17.3 0.56 2.9e-55 Retinal vascular caliber; BRCA cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg24229701 chr12:130821962 PIWIL1 0.39 8.81 0.33 1.15e-17 Menopause (age at onset); BRCA cis rs7647973 1.000 rs974495 chr3:49400482 T/C cg07636037 chr3:49044803 WDR6 0.75 16.43 0.54 7.51e-51 Menarche (age at onset); BRCA cis rs10046574 0.561 rs7789858 chr7:135212285 A/G cg27474649 chr7:135195673 CNOT4 0.64 10.75 0.39 6.98e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg26597838 chr10:835615 NA 0.83 15.2 0.52 9.58e-45 Eosinophil percentage of granulocytes; BRCA cis rs1079204 1.000 rs1017697 chr2:219170462 C/T cg05728596 chr2:219128475 GPBAR1 0.73 9.55 0.35 2.8e-20 Smooth-surface caries; BRCA cis rs7246657 0.943 rs7252325 chr19:37930645 A/G cg23950597 chr19:37808831 NA -0.65 -11.95 -0.43 7.76e-30 Coronary artery calcification; BRCA cis rs6840360 0.533 rs13121178 chr4:152729047 T/C cg22705602 chr4:152727874 NA 0.38 9.86 0.36 1.91e-21 Intelligence (multi-trait analysis); BRCA cis rs10493773 0.609 rs12058974 chr1:86192235 T/A cg17807903 chr1:86174739 ZNHIT6 -0.55 -13.79 -0.48 4.85e-38 Urate levels in overweight individuals; BRCA cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 27.54 0.74 1.1e-110 Chronic sinus infection; BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -14.18 -0.49 6.74e-40 Bipolar disorder and schizophrenia; BRCA cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg05234568 chr11:5960015 NA -0.49 -9.32 -0.35 1.85e-19 DNA methylation (variation); BRCA trans rs34421088 0.623 rs2572433 chr8:11101041 C/T cg06636001 chr8:8085503 FLJ10661 0.45 8.99 0.34 2.87e-18 Neuroticism; BRCA cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg27535305 chr1:53392650 SCP2 -0.32 -7.94 -0.3 9.43e-15 Monocyte count; BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg16606324 chr3:10149918 C3orf24 0.49 9.94 0.37 9.86e-22 Alzheimer's disease; BRCA cis rs2425143 1.000 rs2425142 chr20:34350346 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.83 -0.36 2.51e-21 Blood protein levels; BRCA cis rs4900538 0.963 rs4906205 chr14:102932447 A/G cg18135206 chr14:102964638 TECPR2 1.05 30.45 0.77 1.64e-126 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg07636037 chr3:49044803 WDR6 0.94 26.36 0.72 3.23e-104 Parkinson's disease; BRCA cis rs9325144 0.560 rs1601745 chr12:38647828 G/A cg26384229 chr12:38710491 ALG10B -0.51 -13.31 -0.47 7.34e-36 Morning vs. evening chronotype; BRCA cis rs705471 0.932 rs1106278 chr10:3677358 A/G cg14308648 chr10:3568949 NA 0.35 7.86 0.3 1.6e-14 Capecitabine sensitivity; BRCA cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg07414643 chr4:187882934 NA 0.28 9.65 0.36 1.2e-20 Lobe attachment (rater-scored or self-reported); BRCA trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -10.33 -0.38 3.19e-23 Neuroticism; BRCA cis rs7975161 0.535 rs6539138 chr12:104735928 G/A cg25273343 chr12:104657179 TXNRD1 -0.5 -9.97 -0.37 7.46e-22 Toenail selenium levels; BRCA cis rs887829 0.570 rs10445704 chr2:234600274 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.48 -0.32 1.53e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg14863265 chr7:2801509 GNA12 -0.39 -8.74 -0.33 2.02e-17 Height; BRCA cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 29.48 0.76 2.96e-121 Chronic sinus infection; BRCA cis rs9457247 0.534 rs1130033 chr6:167385623 C/T cg23791538 chr6:167370224 RNASET2 -0.52 -13.45 -0.47 1.65e-36 Crohn's disease; BRCA cis rs3750965 0.920 rs10896420 chr11:68863047 G/A cg06818126 chr11:68850279 TPCN2 -0.37 -8.86 -0.33 7.61e-18 Hair color; BRCA cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg15541040 chr2:3486749 NA -0.45 -10.1 -0.37 2.36e-22 Neurofibrillary tangles; BRCA cis rs7598759 0.527 rs12987949 chr2:232367511 A/G cg19187155 chr2:232395269 NMUR1 0.7 16.64 0.55 6.43e-52 Noise-induced hearing loss; BRCA cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg05535760 chr7:792225 HEATR2 0.77 14.02 0.48 4e-39 Cerebrospinal P-tau181p levels; BRCA cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.42 -0.38 1.38e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs36051895 0.658 rs10974914 chr9:5014332 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.77 -0.33 1.63e-17 Pediatric autoimmune diseases; BRCA cis rs7131987 0.650 rs12366527 chr12:29474256 C/G cg09582351 chr12:29534625 ERGIC2 -0.43 -9.85 -0.36 2.03e-21 QT interval; BRCA cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg13319975 chr6:146136371 FBXO30 -0.4 -9.07 -0.34 1.42e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.07 17.01 0.56 8.2e-54 Platelet count; BRCA cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg18404041 chr3:52824283 ITIH1 -0.31 -9.44 -0.35 7.05e-20 Bipolar disorder; BRCA cis rs7267979 0.966 rs3827014 chr20:25371559 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.24 -0.34 3.68e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3820928 1.000 rs1835158 chr2:227763993 C/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.55e-16 Pulmonary function; BRCA cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg26384229 chr12:38710491 ALG10B -0.65 -14.94 -0.51 1.75e-43 Bladder cancer; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg16145915 chr7:1198662 ZFAND2A -0.43 -10.65 -0.39 1.68e-24 Longevity;Endometriosis; BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs1003719 0.688 rs2835660 chr21:38568882 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs9880211 0.948 rs9844666 chr3:135974216 G/A cg21827317 chr3:136751795 NA -0.46 -8.04 -0.3 4.3e-15 Body mass index;Height; BRCA cis rs9818758 0.556 rs11716614 chr3:49017208 C/G cg01304814 chr3:48885189 PRKAR2A 0.77 7.91 0.3 1.13e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg00530320 chr1:46809349 NSUN4 0.49 9.76 0.36 4.52e-21 Menopause (age at onset); BRCA cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg16850897 chr7:100343110 ZAN -0.58 -11.75 -0.42 5.29e-29 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs708547 0.647 rs781666 chr4:57830981 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.42 -8.16 -0.31 1.74e-15 Response to bleomycin (chromatid breaks); BRCA cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg12311346 chr5:56204834 C5orf35 -0.81 -16.7 -0.55 3.32e-52 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.85e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11890956 chr21:40555474 PSMG1 1.06 31.42 0.78 1.02e-131 Cognitive function; BRCA cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.79e-41 Motion sickness; BRCA cis rs1691799 0.867 rs1168348 chr12:66757168 G/A cg16791601 chr12:66731901 HELB -0.66 -18.09 -0.58 2.15e-59 White blood cell count (basophil); BRCA cis rs1559088 0.501 rs35599132 chr19:33570554 G/A cg17764715 chr19:33622953 WDR88 0.51 8.37 0.31 3.71e-16 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg19346786 chr7:2764209 NA -0.32 -9.26 -0.34 2.96e-19 Height; BRCA trans rs9858542 0.953 rs6779524 chr3:49450449 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.13 -0.34 8.58e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7246657 0.943 rs7408563 chr19:37808585 G/C cg23950597 chr19:37808831 NA -0.65 -11.6 -0.42 2.36e-28 Coronary artery calcification; BRCA trans rs11039798 0.764 rs2089208 chr11:48899860 C/T cg15704280 chr7:45808275 SEPT13 0.59 8.82 0.33 1.07e-17 Axial length; BRCA cis rs514406 0.505 rs269292 chr1:53187911 T/C cg16325326 chr1:53192061 ZYG11B 0.93 25.57 0.71 7.65e-100 Monocyte count; BRCA cis rs758324 0.947 rs6596041 chr5:131198860 C/T cg06307176 chr5:131281290 NA 0.53 10.4 0.38 1.61e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg11752832 chr7:134001865 SLC35B4 -0.49 -12.25 -0.44 3.92e-31 Mean platelet volume; BRCA cis rs4718428 0.705 rs12698547 chr7:66278258 T/C cg12165864 chr7:66369176 NA -0.44 -9.83 -0.36 2.56e-21 Corneal structure; BRCA cis rs6901250 0.610 rs9400964 chr6:117144808 G/T cg12892004 chr6:117198278 RFX6 0.37 8.98 0.33 3.07e-18 C-reactive protein levels; BRCA cis rs6700896 0.897 rs11208696 chr1:66121781 T/G cg04111102 chr1:66153794 NA 0.36 8.86 0.33 7.79e-18 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1018836 0.923 rs7013893 chr8:91563137 G/A cg16814680 chr8:91681699 NA -0.58 -12.41 -0.44 7.45e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs34311866 0.808 rs11248060 chr4:964359 C/T cg14530993 chr4:882597 GAK 0.49 8.75 0.33 1.9e-17 Parkinson's disease; BRCA cis rs858239 1.000 rs156425 chr7:23309119 C/T cg23682824 chr7:23144976 KLHL7 -0.35 -9.02 -0.34 2.2e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg06115741 chr20:33292138 TP53INP2 0.48 10.72 0.39 8.71e-25 Coronary artery disease; BRCA trans rs11098499 0.954 rs10518328 chr4:120401779 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.09 0.3 3.09e-15 Corneal astigmatism; BRCA cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg05985134 chr18:33552581 C18orf21 0.63 11.95 0.43 7.58e-30 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs11098499 0.863 rs13136462 chr4:120543173 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.43 0.32 2.34e-16 Corneal astigmatism; BRCA cis rs10499694 0.933 rs7778349 chr7:50593157 C/T cg18232548 chr7:50535776 DDC -0.39 -9.33 -0.35 1.72e-19 Body mass index; BRCA cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg24308560 chr3:49941425 MST1R 0.39 8.4 0.32 2.86e-16 Intelligence (multi-trait analysis); BRCA cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg10011062 chr15:43941034 CATSPER2 -0.55 -8.09 -0.3 2.94e-15 Lung cancer in ever smokers; BRCA cis rs1878931 0.501 rs17136359 chr16:3420814 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -11.69 -0.42 9.31e-29 Body mass index (adult); BRCA cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.49 0.47 1.16e-36 Colorectal cancer; BRCA cis rs600231 0.542 rs11227199 chr11:65238121 G/A cg01292856 chr11:65242576 NA 0.66 14.93 0.51 1.76e-43 Bone mineral density; BRCA cis rs4845875 0.600 rs11805138 chr1:11833159 T/C cg24844545 chr1:11908347 NPPA 0.36 8.39 0.32 3.07e-16 Midregional pro atrial natriuretic peptide levels; BRCA trans rs4596713 0.536 rs10217168 chr9:71794956 A/G cg16512924 chr15:28394682 HERC2 0.45 10.74 0.39 7.63e-25 Headache; BRCA cis rs7809950 1.000 rs7809950 chr7:107237807 T/C cg23024343 chr7:107201750 COG5 0.43 9.28 0.34 2.58e-19 Coronary artery disease; BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg08470875 chr2:26401718 FAM59B -0.5 -8.19 -0.31 1.4e-15 Gut microbiome composition (summer); BRCA cis rs6547741 0.904 rs1528403 chr2:27846645 C/G cg27432699 chr2:27873401 GPN1 0.38 7.95 0.3 8.41e-15 Oral cavity cancer; BRCA cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg22467129 chr15:76604101 ETFA -0.44 -9.83 -0.36 2.5e-21 Blood metabolite levels; BRCA cis rs4975616 0.839 rs2447853 chr5:1333077 A/G cg07493874 chr5:1342172 CLPTM1L -0.52 -15.04 -0.51 5.51e-44 Lung cancer; BRCA cis rs9649465 1.000 rs6963231 chr7:123374766 A/G cg04330084 chr7:123175371 IQUB -0.33 -8.98 -0.33 2.94e-18 Migraine; BRCA cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg01579765 chr21:45077557 HSF2BP 0.4 10.52 0.38 5.7e-24 Mean corpuscular volume; BRCA cis rs9787249 0.874 rs7520588 chr1:40214525 T/A cg24920358 chr1:40204285 PPIE 0.33 7.81 0.3 2.3e-14 Blood protein levels; BRCA cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg20503657 chr10:835505 NA 0.91 15.14 0.51 1.88e-44 Eosinophil percentage of granulocytes; BRCA trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.68 -0.48 1.51e-37 Extrinsic epigenetic age acceleration; BRCA cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg17063962 chr7:91808500 NA 0.56 13.32 0.47 6.69e-36 Breast cancer; BRCA cis rs9486719 1.000 rs13202675 chr6:97028427 C/T cg06623918 chr6:96969491 KIAA0776 -0.76 -13.4 -0.47 2.88e-36 Migraine;Coronary artery disease; BRCA cis rs6930083 0.527 rs9470367 chr6:36626932 G/C cg08179530 chr6:36648295 CDKN1A -0.53 -11.45 -0.41 1.01e-27 Coronary artery disease; BRCA cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg24692254 chr21:30365293 RNF160 -0.46 -10.21 -0.37 9.05e-23 Dental caries; BRCA cis rs9790314 0.502 rs34972965 chr3:160984296 G/A cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Morning vs. evening chronotype; BRCA cis rs9875589 0.509 rs1488377 chr3:14073178 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.32 8.09 0.3 2.95e-15 Ovarian reserve; BRCA cis rs67460515 0.563 rs6772723 chr3:160895074 C/G cg17135325 chr3:160939158 NMD3 0.41 8.0 0.3 5.93e-15 Parkinson's disease; BRCA cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg25019033 chr10:957182 NA -0.42 -8.05 -0.3 4.14e-15 Eosinophil percentage of granulocytes; BRCA cis rs7127900 0.583 rs11043147 chr11:2234169 C/G cg12428727 chr11:2234665 NA 0.54 13.6 0.47 3.53e-37 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); BRCA cis rs4363385 0.818 rs1334850 chr1:153004519 G/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.22 -0.34 4.33e-19 Inflammatory skin disease; BRCA cis rs6062302 0.549 rs4809586 chr20:62249402 C/T cg03425785 chr20:62221387 GMEB2 0.51 8.23 0.31 1.07e-15 Glioblastoma; BRCA cis rs6977660 0.598 rs10239147 chr7:19787459 T/C cg05791153 chr7:19748676 TWISTNB 0.56 10.21 0.37 9.28e-23 Thyroid stimulating hormone; BRCA trans rs7178375 1.000 rs1474382 chr15:31214649 A/G cg04373760 chr16:53404718 NA 0.5 9.3 0.35 2.24e-19 Hypertriglyceridemia; BRCA cis rs11758351 0.518 rs78871852 chr6:26221566 A/T cg01420254 chr6:26195488 NA 0.56 8.73 0.33 2.19e-17 Gout;Renal underexcretion gout; BRCA cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg05347473 chr6:146136440 FBXO30 0.42 8.48 0.32 1.57e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg18225595 chr11:63971243 STIP1 0.52 12.95 0.46 3.16e-34 Platelet count; BRCA cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg11812906 chr14:75593930 NEK9 0.67 15.2 0.52 9.49e-45 Height; BRCA cis rs2180341 0.782 rs6912750 chr6:127723081 A/T cg24812749 chr6:127587940 RNF146 0.68 15.55 0.52 1.82e-46 Breast cancer; BRCA cis rs17741873 0.779 rs2242255 chr10:75597289 T/A cg07699608 chr10:75541558 CHCHD1 0.5 8.19 0.31 1.38e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg24130564 chr14:104152367 KLC1 -0.34 -7.96 -0.3 8.14e-15 Body mass index; BRCA cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg15017067 chr4:17643749 FAM184B 0.3 8.4 0.32 2.79e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9815354 0.904 rs9852991 chr3:41875455 C/A cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs9527 0.662 rs4919687 chr10:104595248 G/A cg04362960 chr10:104952993 NT5C2 0.46 10.03 0.37 4.55e-22 Arsenic metabolism; BRCA cis rs9287719 0.967 rs9679581 chr2:10751736 G/A cg02196655 chr2:10830764 NOL10 -0.29 -7.83 -0.3 1.98e-14 Prostate cancer; BRCA cis rs6831352 0.879 rs29001215 chr4:100051722 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs4389656 0.784 rs274723 chr5:6718563 A/G cg10857441 chr5:6722123 POLS -0.24 -7.86 -0.3 1.65e-14 Coronary artery disease; BRCA cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg25173405 chr17:45401733 C17orf57 0.52 11.24 0.41 7.13e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg25817165 chr18:72167213 CNDP2 -0.74 -18.35 -0.59 9.85e-61 Refractive error; BRCA cis rs6546550 0.901 rs6721891 chr2:70146121 A/G cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.73e-28 Prevalent atrial fibrillation; BRCA cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg08822215 chr16:89438651 ANKRD11 -0.37 -7.89 -0.3 1.33e-14 Multiple myeloma (IgH translocation); BRCA trans rs412658 0.668 rs7253490 chr19:22293706 A/C cg17074339 chr11:11642133 GALNTL4 0.4 8.87 0.33 7.06e-18 Telomere length; BRCA cis rs9467773 0.534 rs34453863 chr6:26628005 T/C cg11502198 chr6:26597334 ABT1 0.52 9.98 0.37 6.79e-22 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.744 rs11181635 chr12:38378420 C/T cg06521331 chr12:34319734 NA -0.51 -9.14 -0.34 8.45e-19 Bladder cancer; BRCA cis rs13102973 0.899 rs13119071 chr4:135909862 G/T cg14419869 chr4:135874104 NA 0.45 8.96 0.33 3.41e-18 Subjective well-being; BRCA cis rs1008375 1.000 rs6848360 chr4:17634442 G/T cg02297831 chr4:17616191 MED28 0.38 8.88 0.33 6.9e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg13010199 chr12:38710504 ALG10B 0.52 9.88 0.36 1.64e-21 Bladder cancer; BRCA cis rs6815814 0.898 rs2174284 chr4:38859339 C/T cg02016764 chr4:38805732 TLR1 -0.53 -8.12 -0.31 2.43e-15 Breast cancer; BRCA cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg17173187 chr15:85201210 NMB 0.41 8.68 0.32 3.18e-17 Schizophrenia; BRCA cis rs7572733 0.534 rs700674 chr2:198693703 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.19 0.37 1.11e-22 Dermatomyositis; BRCA cis rs6582630 0.638 rs12423236 chr12:38548162 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.28 -0.38 4.86e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11890956 chr21:40555474 PSMG1 -0.81 -19.28 -0.61 1.25e-65 Cognitive function; BRCA cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg02155558 chr15:43621948 ADAL;LCMT2 -0.71 -12.44 -0.44 5.58e-32 Lung cancer in ever smokers; BRCA cis rs6430585 0.646 rs1057031 chr2:136633962 G/A cg07169764 chr2:136633963 MCM6 1.32 33.29 0.8 1.04e-141 Corneal structure; BRCA cis rs1801251 0.778 rs2250665 chr2:233752639 A/T cg08000102 chr2:233561755 GIGYF2 -0.46 -10.03 -0.37 4.4e-22 Coronary artery disease; BRCA cis rs796364 1.000 rs281794 chr2:200846666 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.3 0.47 8.12e-36 Schizophrenia; BRCA cis rs7520050 0.931 rs35743647 chr1:46407252 T/C cg24296786 chr1:45957014 TESK2 0.44 9.87 0.36 1.71e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2549003 0.933 rs7719499 chr5:131814091 C/G cg21138405 chr5:131827807 IRF1 0.39 12.34 0.44 1.6e-31 Asthma (sex interaction); BRCA cis rs11025559 0.716 rs1596376 chr11:20454229 T/C cg19653624 chr11:20408972 PRMT3 -0.45 -10.37 -0.38 2.07e-23 Pursuit maintenance gain; BRCA cis rs9457247 0.637 rs9459846 chr6:167441023 T/G cg07741184 chr6:167504864 NA 0.27 8.0 0.3 5.67e-15 Crohn's disease; BRCA cis rs7953249 0.656 rs2243616 chr12:121406370 G/T cg02403541 chr12:121454288 C12orf43 -0.46 -9.07 -0.34 1.48e-18 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg05340658 chr4:99064831 C4orf37 0.54 8.71 0.33 2.52e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs12368653 0.840 rs3816896 chr12:58195773 C/T cg02175503 chr12:58329896 NA -0.42 -8.99 -0.34 2.82e-18 Multiple sclerosis; BRCA cis rs2742234 0.868 rs2505512 chr10:43633596 G/A cg15436174 chr10:43711423 RASGEF1A -0.42 -8.91 -0.33 5.14e-18 Hirschsprung disease; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 19.97 0.62 2.74e-69 Platelet count; BRCA cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg05868516 chr6:26286170 HIST1H4H -0.48 -10.97 -0.4 9.05e-26 Educational attainment; BRCA cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg08000102 chr2:233561755 GIGYF2 0.62 13.54 0.47 6.92e-37 Coronary artery disease; BRCA cis rs3741151 0.773 rs58334887 chr11:73171510 A/C cg17517138 chr11:73019481 ARHGEF17 0.88 12.46 0.44 4.72e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg21724239 chr8:58056113 NA 0.64 9.9 0.36 1.34e-21 Developmental language disorder (linguistic errors); BRCA cis rs13040088 0.518 rs2427452 chr20:61577275 T/C cg23096297 chr20:61557774 DIDO1 -0.67 -14.15 -0.49 9.39e-40 Menopause (age at onset); BRCA trans rs9944715 0.954 rs4453594 chr18:43788332 G/T cg01718231 chr17:29326311 RNF135 -0.46 -8.96 -0.33 3.58e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg03188948 chr7:1209495 NA 0.69 15.13 0.51 1.98e-44 Longevity;Endometriosis; BRCA cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg02544614 chr20:61657117 NA 0.29 8.18 0.31 1.53e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2011503 1.000 rs75582668 chr19:19569023 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg05340658 chr4:99064831 C4orf37 0.62 14.87 0.51 3.69e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs9816226 0.618 rs869399 chr3:185826764 C/T cg00760338 chr3:185826511 ETV5 0.55 12.06 0.43 2.61e-30 Obesity;Body mass index; BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 18.67 0.59 2.04e-62 Platelet count; BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.85 -0.3 1.74e-14 Total body bone mineral density; BRCA cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg08859206 chr1:53392774 SCP2 0.61 12.69 0.45 4.64e-33 Monocyte count; BRCA cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg04756594 chr16:24857601 SLC5A11 0.48 10.1 0.37 2.35e-22 Intelligence (multi-trait analysis); BRCA cis rs10911251 0.528 rs10911264 chr1:183115040 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.36 0.54 1.69e-50 Colorectal cancer; BRCA cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs6867032 0.834 rs10043083 chr5:1995687 C/G cg26168224 chr5:2018326 NA -0.55 -14.23 -0.49 3.94e-40 Gut microbiome composition (winter); BRCA cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg17971929 chr21:40555470 PSMG1 0.81 19.72 0.62 5.65e-68 Cognitive function; BRCA cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9403521 1.000 rs6907410 chr6:143995142 A/G cg18240653 chr6:144019428 PHACTR2 -0.42 -8.28 -0.31 7.18e-16 Obesity-related traits; BRCA cis rs11887277 0.708 rs12470698 chr2:27063261 A/G cg12368169 chr2:27073192 DPYSL5 -0.33 -9.98 -0.37 6.77e-22 Obesity-related traits; BRCA cis rs4363385 0.747 rs4845332 chr1:152982632 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.82e-16 Inflammatory skin disease; BRCA cis rs1298062 0.563 rs2445828 chr19:50941807 A/G cg11430371 chr19:50961752 MYBPC2 0.31 7.94 0.3 9.04e-15 Age of smoking initiation; BRCA cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg22800045 chr5:56110881 MAP3K1 0.46 9.1 0.34 1.14e-18 Initial pursuit acceleration; BRCA trans rs2270927 0.510 rs67771044 chr5:75577819 A/G cg13563193 chr19:33072644 PDCD5 0.91 11.21 0.41 9.34e-27 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA cis rs72634258 0.842 rs4908727 chr1:8163122 C/T cg00042356 chr1:8021962 PARK7 0.57 9.51 0.35 3.7e-20 Inflammatory bowel disease; BRCA trans rs11098499 0.697 rs6832410 chr4:120296800 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs977987 0.527 rs62059844 chr16:75429737 T/C cg03315344 chr16:75512273 CHST6 0.52 12.36 0.44 1.31e-31 Dupuytren's disease; BRCA trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.22 0.54 8.5e-50 Intelligence (multi-trait analysis); BRCA cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg16414030 chr3:133502952 NA -0.53 -12.33 -0.44 1.77e-31 Iron status biomarkers; BRCA cis rs2239547 0.618 rs4687658 chr3:52860366 C/G cg11645453 chr3:52864694 ITIH4 0.49 11.98 0.43 5.43e-30 Schizophrenia; BRCA cis rs6748734 0.817 rs4465762 chr2:241798862 G/A cg02820040 chr2:241836501 C2orf54 -0.46 -9.12 -0.34 9.28e-19 Urinary metabolites; BRCA trans rs11098499 0.863 rs11731756 chr4:120478696 T/G cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.54 -9.73 -0.36 6.13e-21 Renal function-related traits (BUN); BRCA cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 1.000 rs17376207 chr5:93545524 C/T cg25358565 chr5:93447407 FAM172A -1.12 -18.1 -0.58 1.99e-59 Diabetic retinopathy; BRCA cis rs7662987 0.517 rs3018047 chr4:100014510 C/T cg12011299 chr4:100065546 ADH4 -0.46 -10.57 -0.39 3.61e-24 Smoking initiation; BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.42 0.66 1.41e-82 Platelet count; BRCA cis rs61861422 0.516 rs12412216 chr10:134393338 C/T cg13441142 chr10:134499734 INPP5A 0.4 8.11 0.31 2.5e-15 Primary sclerosing cholangitis; BRCA cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg08048268 chr3:133502702 NA -0.43 -10.97 -0.4 9.38e-26 Iron status biomarkers; BRCA cis rs4642101 0.737 rs4299468 chr3:12825559 G/A cg05775895 chr3:12838266 CAND2 0.35 7.82 0.3 2.24e-14 QRS complex (12-leadsum); BRCA cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg21535247 chr6:8435926 SLC35B3 0.38 8.67 0.32 3.58e-17 Motion sickness; BRCA cis rs6545883 0.826 rs2694617 chr2:61537214 G/A cg15711740 chr2:61764176 XPO1 0.51 13.07 0.46 9.58e-35 Tuberculosis; BRCA cis rs1829883 0.898 rs2511899 chr5:98776319 G/A cg08333243 chr5:99726346 NA -0.36 -8.48 -0.32 1.58e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.15 0.31 1.88e-15 Schizophrenia; BRCA cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.34 0.31 4.57e-16 Cognitive ability; BRCA cis rs6840258 0.660 rs72667737 chr4:87876416 C/T cg08197287 chr4:87952173 AFF1 -0.47 -8.47 -0.32 1.71e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs7737355 0.898 rs13164236 chr5:131079808 C/T cg06307176 chr5:131281290 NA 0.52 10.08 0.37 2.86e-22 Life satisfaction; BRCA cis rs11098499 0.954 rs11729521 chr4:120416788 T/C cg09307838 chr4:120376055 NA 0.72 15.2 0.52 9.32e-45 Corneal astigmatism; BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.77 0.42 4.43e-29 Tonsillectomy; BRCA trans rs17685 0.558 rs60787921 chr7:75792844 C/A cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.03 -0.34 2.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg24308560 chr3:49941425 MST1R -0.4 -8.57 -0.32 7.83e-17 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs919433 0.929 rs1366836 chr2:198172148 T/G cg10820045 chr2:198174542 NA -0.46 -10.82 -0.39 3.75e-25 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1691799 0.899 rs2951656 chr12:66732273 T/G cg16791601 chr12:66731901 HELB -0.63 -16.85 -0.55 5.7e-53 White blood cell count (basophil); BRCA cis rs66887589 0.776 rs10518337 chr4:120574874 A/C cg09307838 chr4:120376055 NA -0.4 -8.07 -0.3 3.5e-15 Diastolic blood pressure; BRCA cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg17971929 chr21:40555470 PSMG1 0.46 10.2 0.37 9.9e-23 Menarche (age at onset); BRCA cis rs4363385 0.747 rs2879488 chr1:152975241 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs9858542 0.953 rs11710037 chr3:49675334 C/G cg03060546 chr3:49711283 APEH -0.58 -11.81 -0.42 3.12e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg03929089 chr4:120376271 NA 0.73 14.63 0.5 5.09e-42 Coronary artery disease; BRCA trans rs7615952 0.576 rs6804482 chr3:125815762 C/T cg07211511 chr3:129823064 LOC729375 -0.62 -10.91 -0.4 1.56e-25 Blood pressure (smoking interaction); BRCA cis rs6430585 0.528 rs309165 chr2:136667301 T/C cg07169764 chr2:136633963 MCM6 1.08 23.95 0.69 5.98e-91 Corneal structure; BRCA cis rs68170813 0.559 rs12537730 chr7:106844281 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.49 -0.32 1.44e-16 Coronary artery disease; BRCA cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs72781680 0.752 rs56152044 chr2:23927680 A/G cg08917208 chr2:24149416 ATAD2B 1.05 13.78 0.48 5.29e-38 Lymphocyte counts; BRCA cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg02734326 chr4:10020555 SLC2A9 0.37 8.42 0.32 2.51e-16 Bone mineral density; BRCA cis rs7715806 0.500 rs4704233 chr5:75000792 G/A cg19683494 chr5:74908142 NA 0.5 8.06 0.3 3.69e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7264396 0.563 rs2425081 chr20:34299733 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Total cholesterol levels; BRCA cis rs9653442 0.835 rs1561230 chr2:100746642 C/T cg07810366 chr2:100720526 AFF3 0.31 8.08 0.3 3.28e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs2549003 1.000 rs2070724 chr5:131822072 A/G cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA cis rs6728642 1.000 rs113934577 chr2:97888047 G/A cg26665480 chr2:98280029 ACTR1B -0.65 -7.83 -0.3 2.06e-14 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg11941060 chr3:133502564 NA -0.5 -11.81 -0.42 2.87e-29 Iron status biomarkers; BRCA cis rs11608355 0.545 rs7139106 chr12:109908640 G/A cg05360138 chr12:110035743 NA 0.71 13.05 0.46 1.11e-34 Neuroticism; BRCA cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg24558204 chr6:135376177 HBS1L 0.6 16.25 0.54 5.98e-50 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1405069 0.809 rs1063021 chr6:36932327 A/G cg26433444 chr6:36932349 PI16 0.47 12.18 0.43 7.67e-31 Chemerin levels; BRCA cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg14863265 chr7:2801509 GNA12 0.43 9.72 0.36 6.57e-21 Height; BRCA cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg05890377 chr2:74357713 NA 0.48 11.39 0.41 1.79e-27 Gestational age at birth (maternal effect); BRCA cis rs2404602 0.684 rs57682236 chr15:76868478 G/A cg23625390 chr15:77176239 SCAPER -0.54 -12.71 -0.45 3.63e-33 Blood metabolite levels; BRCA cis rs7246657 0.943 rs10420722 chr19:37973774 C/G cg18154014 chr19:37997991 ZNF793 0.62 11.82 0.42 2.78e-29 Coronary artery calcification; BRCA cis rs3862030 0.694 rs1984795 chr10:104226830 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.13 -0.43 1.25e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg03213289 chr20:61660250 NA 0.62 15.94 0.53 1.99e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs10484885 0.775 rs72919985 chr6:90534641 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.87 -0.36 1.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10911251 0.528 rs2182020 chr1:183074964 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.43e-58 Colorectal cancer; BRCA cis rs495337 0.699 rs6020074 chr20:48448659 T/C cg17835207 chr20:48524531 SPATA2 0.52 11.74 0.42 5.97e-29 Psoriasis; BRCA cis rs6840360 0.571 rs62327272 chr4:152545090 A/C cg22705602 chr4:152727874 NA -0.32 -8.07 -0.3 3.39e-15 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.79 0.36 3.53e-21 Bipolar disorder; BRCA cis rs8005677 1.000 rs1043209 chr14:23373986 A/G cg01529538 chr14:23388837 RBM23 -0.41 -11.3 -0.41 4.22e-27 Cognitive ability (multi-trait analysis); BRCA cis rs4268898 0.608 rs72793980 chr2:24428859 T/C cg06627628 chr2:24431161 ITSN2 -0.64 -11.86 -0.42 1.91e-29 Asthma; BRCA trans rs11098499 0.818 rs7688802 chr4:120451668 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs2425143 1.000 rs2378409 chr20:34392464 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.6 -0.32 6.23e-17 Blood protein levels; BRCA cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg27129171 chr3:47204927 SETD2 -0.7 -16.79 -0.55 1.06e-52 Colorectal cancer; BRCA cis rs4481887 0.800 rs10788780 chr1:248483598 G/A cg13385794 chr1:248469461 NA 0.27 8.04 0.3 4.37e-15 Common traits (Other); BRCA cis rs34779708 0.966 rs12769575 chr10:35435927 A/T cg03585969 chr10:35415529 CREM 0.56 11.6 0.42 2.21e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 1.000 rs73609764 chr8:58192971 G/A cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs736408 0.522 rs998909 chr3:52805093 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.53 0.38 4.94e-24 Bipolar disorder; BRCA cis rs6570726 0.599 rs9376951 chr6:145898911 C/T cg05347473 chr6:146136440 FBXO30 0.6 11.65 0.42 1.37e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg16339924 chr4:17578868 LAP3 0.62 15.37 0.52 1.29e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg06671706 chr8:8559999 CLDN23 0.43 8.38 0.31 3.48e-16 Obesity-related traits; BRCA cis rs13095912 0.785 rs6783023 chr3:185330189 A/G cg11274856 chr3:185301563 NA 0.54 13.0 0.46 1.87e-34 Systolic blood pressure; BRCA cis rs12541635 0.639 rs10955408 chr8:107020789 G/A cg10147462 chr8:107024639 NA 0.38 10.53 0.38 5.01e-24 Age of smoking initiation; BRCA cis rs4689388 0.926 rs4343789 chr4:6285228 C/G cg25554036 chr4:6271136 WFS1 0.43 10.24 0.38 6.65e-23 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs9291683 0.620 rs11722946 chr4:10125990 A/G cg26043149 chr18:55253948 FECH -0.41 -8.96 -0.33 3.44e-18 Bone mineral density; BRCA cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg18404041 chr3:52824283 ITIH1 -0.44 -13.05 -0.46 1.15e-34 Bipolar disorder; BRCA trans rs3733585 0.638 rs7377625 chr4:9953099 T/C cg26043149 chr18:55253948 FECH -0.36 -8.07 -0.3 3.6e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs769267 0.931 rs15622 chr19:19468734 G/A cg01262667 chr19:19385393 TM6SF2 -0.41 -10.64 -0.39 1.88e-24 Tonsillectomy; BRCA cis rs3772130 0.962 rs7629369 chr3:121566282 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.83 0.39 3.25e-25 Cognitive performance; BRCA cis rs10883723 0.810 rs7072351 chr10:104265047 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.34 0.59 1.17e-60 Allergic disease (asthma, hay fever or eczema); BRCA cis rs78487399 0.908 rs17031092 chr2:43809248 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -8.32 -0.31 5.29e-16 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg03354898 chr7:1950403 MAD1L1 -0.48 -9.73 -0.36 5.68e-21 Bipolar disorder and schizophrenia; BRCA cis rs2070488 0.804 rs4678605 chr3:38444489 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.7 0.57 2.46e-57 Electrocardiographic conduction measures; BRCA cis rs317689 0.718 rs645026 chr12:69757931 G/A cg20891283 chr12:69753455 YEATS4 0.56 11.03 0.4 5.19e-26 Response to diuretic therapy; BRCA cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg14019146 chr3:50243930 SLC38A3 0.41 10.03 0.37 4.33e-22 Body mass index; BRCA cis rs2749592 0.611 rs176888 chr10:38406161 C/A cg00409905 chr10:38381863 ZNF37A -0.5 -9.25 -0.34 3.21e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4930103 0.602 rs170101 chr11:2008936 C/T cg06197492 chr11:2016605 H19 0.44 8.96 0.33 3.6e-18 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA trans rs12310956 0.510 rs10844694 chr12:33865682 A/C cg26384229 chr12:38710491 ALG10B 0.39 9.05 0.34 1.69e-18 Morning vs. evening chronotype; BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg22535103 chr8:58192502 C8orf71 -0.52 -8.84 -0.33 9.3e-18 Developmental language disorder (linguistic errors); BRCA cis rs10267417 0.603 rs116877803 chr7:19925205 C/T cg05791153 chr7:19748676 TWISTNB 0.42 7.86 0.3 1.66e-14 Night sleep phenotypes; BRCA trans rs6582630 0.502 rs3902522 chr12:38271203 T/C cg06521331 chr12:34319734 NA -0.51 -9.75 -0.36 4.86e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs17401966 0.540 rs4846221 chr1:10472026 C/A cg03954927 chr1:10346856 KIF1B 0.35 10.44 0.38 1.18e-23 Hepatocellular carcinoma; BRCA cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg08999081 chr20:33150536 PIGU 0.5 14.24 0.49 3.57e-40 Coronary artery disease; BRCA trans rs28735056 0.587 rs8093548 chr18:77636451 G/A cg05926928 chr17:57297772 GDPD1 -0.51 -10.44 -0.38 1.15e-23 Schizophrenia; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg12564285 chr5:131593104 PDLIM4 -0.41 -10.29 -0.38 4.27e-23 Acylcarnitine levels; BRCA trans rs11098499 0.954 rs17009122 chr4:120362403 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.97 0.3 7.32e-15 Corneal astigmatism; BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg03709012 chr19:19516395 GATAD2A 0.81 19.08 0.6 1.51e-64 Tonsillectomy; BRCA cis rs3806843 1.000 rs4151682 chr5:140201264 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.87 -0.36 1.83e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs225245 0.817 rs225273 chr17:33970935 A/T cg19694781 chr19:47549865 TMEM160 -0.33 -8.2 -0.31 1.36e-15 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg25019033 chr10:957182 NA -0.41 -7.9 -0.3 1.23e-14 Eosinophil percentage of granulocytes; BRCA cis rs56104184 0.723 rs73063515 chr19:49407715 C/T cg21252483 chr19:49399788 TULP2 -0.52 -11.28 -0.41 4.76e-27 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs8062405 0.755 rs55792032 chr16:28599411 A/G cg16576597 chr16:28551801 NUPR1 0.32 8.89 0.33 6.37e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg05707623 chr12:122985044 ZCCHC8 -0.4 -8.09 -0.3 3.08e-15 Body mass index; BRCA cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg00990874 chr7:1149470 C7orf50 -0.54 -9.76 -0.36 4.41e-21 Bronchopulmonary dysplasia; BRCA cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg02376097 chr19:46275166 DMPK 0.41 9.24 0.34 3.47e-19 Coronary artery disease; BRCA cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg08392591 chr16:89556376 ANKRD11 0.56 13.83 0.48 3.03e-38 Multiple myeloma (IgH translocation); BRCA cis rs6840360 0.571 rs1473305 chr4:152511721 T/G cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 6.04e-15 Intelligence (multi-trait analysis); BRCA cis rs1580019 0.961 rs4320456 chr7:32496003 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.08 0.54 4.26e-49 Cognitive ability; BRCA cis rs1499972 0.941 rs1456182 chr3:117659680 C/T cg07612923 chr3:117604196 NA 0.58 7.9 0.3 1.25e-14 Schizophrenia; BRCA cis rs67311347 1.000 rs9849992 chr3:40402140 C/T cg09455208 chr3:40491958 NA 0.41 9.75 0.36 5.14e-21 Renal cell carcinoma; BRCA cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg25427524 chr10:38739819 LOC399744 0.7 17.16 0.56 1.48e-54 Extrinsic epigenetic age acceleration; BRCA cis rs2239547 0.563 rs4302374 chr3:52905802 T/C cg18404041 chr3:52824283 ITIH1 -0.33 -8.27 -0.31 7.52e-16 Schizophrenia; BRCA cis rs796825 0.695 rs2673712 chr3:120015214 A/T cg21790991 chr3:120137480 FSTL1 -0.32 -7.94 -0.3 9.32e-15 HIV-1 susceptibility; BRCA cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg08975724 chr8:8085496 FLJ10661 0.47 8.81 0.33 1.16e-17 Red cell distribution width; BRCA cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.96 -0.4 9.74e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2153535 0.580 rs7450817 chr6:8481421 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.01e-40 Motion sickness; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.82 -14.65 -0.5 4.32e-42 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9311474 0.596 rs524986 chr3:52228496 T/C cg15698299 chr3:52233019 ALAS1 -0.36 -8.36 -0.31 3.8e-16 Electroencephalogram traits; BRCA cis rs6964587 0.620 rs7808587 chr7:91620096 G/A cg17063962 chr7:91808500 NA 0.55 12.64 0.45 7.77e-33 Breast cancer; BRCA cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg11632617 chr15:75315747 PPCDC -0.38 -8.43 -0.32 2.22e-16 Blood trace element (Zn levels); BRCA trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg21775007 chr8:11205619 TDH -0.41 -8.56 -0.32 8.14e-17 Neuroticism; BRCA cis rs6684514 0.961 rs10908503 chr1:156300683 C/T cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2820315 0.505 rs10800792 chr1:201811144 G/A cg11586189 chr1:201857591 SHISA4 0.32 8.41 0.32 2.58e-16 Body mass index;Body mass index (joint analysis main effects and physical activity interaction);Coronary artery disease;Body mass index in physically active individuals; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.73 -12.66 -0.45 6.18e-33 Platelet count; BRCA cis rs151349 0.555 rs151343 chr20:57583298 C/G cg23907860 chr20:57583709 CTSZ 0.61 15.07 0.51 3.89e-44 Platelet distribution width; BRCA cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg05623727 chr3:50126028 RBM5 0.43 8.19 0.31 1.43e-15 Menarche (age at onset); BRCA cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg24531977 chr5:56204891 C5orf35 -0.81 -16.77 -0.55 1.38e-52 Initial pursuit acceleration; BRCA cis rs6860806 0.531 rs270607 chr5:131649186 A/G cg24060327 chr5:131705240 SLC22A5 -0.59 -11.42 -0.41 1.28e-27 Breast cancer; BRCA cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg24642439 chr20:33292090 TP53INP2 -0.53 -11.61 -0.42 1.99e-28 Glomerular filtration rate (creatinine); BRCA cis rs7975161 0.638 rs7137288 chr12:104591886 C/A cg25273343 chr12:104657179 TXNRD1 -0.38 -9.06 -0.34 1.63e-18 Toenail selenium levels; BRCA cis rs9394841 0.692 rs9381097 chr6:41847800 A/G cg08135965 chr6:41755394 TOMM6 -0.47 -7.88 -0.3 1.42e-14 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg22535103 chr8:58192502 C8orf71 -0.6 -13.08 -0.46 8.35e-35 Developmental language disorder (linguistic errors); BRCA cis rs11920090 0.858 rs11929535 chr3:170710456 C/T cg09710316 chr3:170744871 SLC2A2 0.5 8.0 0.3 5.93e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.1 -0.4 2.73e-26 Schizophrenia; BRCA cis rs7267979 1.000 rs2027004 chr20:25350618 C/T cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg17330251 chr7:94953956 PON1 -0.42 -8.58 -0.32 7.32e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs3768617 0.510 rs10911242 chr1:183072147 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.31e-58 Fuchs's corneal dystrophy; BRCA cis rs7824557 0.591 rs2736282 chr8:11225480 C/T cg21775007 chr8:11205619 TDH 0.6 12.99 0.46 2.11e-34 Retinal vascular caliber; BRCA cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15369054 chr17:80825471 TBCD 0.55 13.21 0.46 2.13e-35 Breast cancer; BRCA cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg11764359 chr7:65958608 NA 0.79 19.31 0.61 8.49e-66 Aortic root size; BRCA cis rs2204008 0.548 rs8189475 chr12:38037115 C/T cg26384229 chr12:38710491 ALG10B 0.57 13.41 0.47 2.49e-36 Bladder cancer; BRCA cis rs61931739 0.500 rs9795938 chr12:34587739 C/T cg06521331 chr12:34319734 NA 0.53 10.31 0.38 3.68e-23 Morning vs. evening chronotype; BRCA cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs7246657 0.653 rs10425441 chr19:37670648 T/C cg18154014 chr19:37997991 ZNF793 0.56 9.36 0.35 1.38e-19 Coronary artery calcification; BRCA cis rs7267979 1.000 rs6138575 chr20:25438952 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.47 0.32 1.71e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9420 0.961 rs2847308 chr11:57498232 C/T cg19752551 chr11:57585705 CTNND1 0.42 10.79 0.39 4.69e-25 Schizophrenia; BRCA cis rs8114671 0.935 rs6058198 chr20:33748253 T/A cg07148914 chr20:33460835 GGT7 0.41 8.63 0.32 4.75e-17 Height; BRCA cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg21573476 chr21:45109991 RRP1B -0.43 -11.5 -0.41 5.94e-28 Mean corpuscular volume; BRCA cis rs4363385 0.720 rs1338179 chr1:152981548 T/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg11764359 chr7:65958608 NA -0.76 -16.7 -0.55 3.01e-52 Aortic root size; BRCA cis rs7103648 1.000 rs10838705 chr11:47424931 G/A cg03711944 chr11:47377212 SPI1 -0.42 -11.54 -0.42 3.99e-28 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs523522 0.962 rs687873 chr12:121019634 G/A cg27279351 chr12:120934652 DYNLL1 0.56 13.41 0.47 2.63e-36 High light scatter reticulocyte count; BRCA cis rs2836974 0.831 rs4375956 chr21:40521788 G/A cg11644478 chr21:40555479 PSMG1 0.8 17.53 0.57 1.72e-56 Cognitive function; BRCA cis rs6963495 0.818 rs1355614 chr7:105179176 A/G cg19920283 chr7:105172520 RINT1 0.66 13.35 0.47 4.8e-36 Bipolar disorder (body mass index interaction); BRCA cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg24642439 chr20:33292090 TP53INP2 -0.41 -8.41 -0.32 2.64e-16 Height; BRCA trans rs208520 0.754 rs851592 chr6:66875175 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -19.39 -0.61 3.14e-66 Exhaled nitric oxide output; BRCA cis rs7945718 0.805 rs6486059 chr11:12824581 A/G cg25843174 chr11:12811716 TEAD1 -0.22 -8.39 -0.32 3.05e-16 Educational attainment (years of education); BRCA cis rs6942756 1.000 rs66864889 chr7:128952560 G/A cg02491457 chr7:128862824 NA -0.71 -13.98 -0.48 5.85e-39 White matter hyperintensity burden; BRCA cis rs9650657 0.504 rs10108347 chr8:11033517 G/C cg21775007 chr8:11205619 TDH -0.44 -9.32 -0.35 1.84e-19 Neuroticism; BRCA cis rs2549003 1.000 rs7701588 chr5:131819970 T/C cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.65e-34 Asthma (sex interaction); BRCA cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg13010199 chr12:38710504 ALG10B 0.57 12.61 0.45 1.06e-32 Heart rate; BRCA cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg09035930 chr12:129282057 SLC15A4 -0.48 -12.71 -0.45 3.67e-33 Systemic lupus erythematosus; BRCA cis rs12474201 0.925 rs1058157 chr2:46988275 G/A cg06386533 chr2:46925753 SOCS5 0.87 18.87 0.6 1.84e-63 Height; BRCA cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg14819504 chr2:160761413 LY75 -0.4 -9.71 -0.36 7.01e-21 Crohn's disease;Inflammatory bowel disease; BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg26119090 chr2:26468346 HADHA;HADHB 1.05 22.15 0.66 4.01e-81 Gut microbiome composition (summer); BRCA trans rs877282 0.891 rs10904557 chr10:797490 C/T cg22713356 chr15:30763199 NA -1.37 -28.0 -0.74 3.4e-113 Uric acid levels; BRCA cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg08219700 chr8:58056026 NA 0.44 7.92 0.3 1.08e-14 Developmental language disorder (linguistic errors); BRCA trans rs11039798 0.841 rs10839174 chr11:48931185 G/A cg15704280 chr7:45808275 SEPT13 0.6 8.93 0.33 4.6e-18 Axial length; BRCA cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg21951975 chr1:209979733 IRF6 0.37 7.97 0.3 7.12e-15 Cleft lip with or without cleft palate; BRCA cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.72e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs7246657 0.943 rs8109038 chr19:38015709 A/G cg23950597 chr19:37808831 NA 0.7 12.54 0.44 2.07e-32 Coronary artery calcification; BRCA cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.59 11.42 0.41 1.35e-27 Multiple sclerosis; BRCA cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.8 -0.33 1.31e-17 Monocyte percentage of white cells; BRCA cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg18479299 chr3:125709523 NA -0.51 -8.28 -0.31 7.32e-16 Blood pressure (smoking interaction); BRCA cis rs6088590 0.561 rs6059934 chr20:33178324 G/T cg08999081 chr20:33150536 PIGU 0.48 13.39 0.47 3.09e-36 Coronary artery disease; BRCA cis rs10911232 0.507 rs4652762 chr1:182993960 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg00071950 chr4:10020882 SLC2A9 0.63 15.69 0.53 3.79e-47 Bone mineral density; BRCA cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg08975724 chr8:8085496 FLJ10661 0.42 8.74 0.33 2.03e-17 Neuroticism; BRCA cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs67460515 0.892 rs73026976 chr3:160964271 G/A cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Parkinson's disease; BRCA cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg00409905 chr10:38381863 ZNF37A -0.53 -11.43 -0.41 1.22e-27 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg25036284 chr2:26402008 FAM59B 0.89 15.6 0.53 1.03e-46 Gut microbiome composition (summer); BRCA cis rs2637266 0.935 rs1978927 chr10:78399786 A/T cg18941641 chr10:78392320 NA 0.35 8.12 0.31 2.41e-15 Pulmonary function; BRCA cis rs2115630 0.967 rs12595786 chr15:85336670 T/C cg11189052 chr15:85197271 WDR73 -0.34 -7.98 -0.3 6.63e-15 P wave terminal force; BRCA cis rs12310956 0.532 rs1589902 chr12:33989289 G/A cg06521331 chr12:34319734 NA -0.56 -10.84 -0.39 2.95e-25 Morning vs. evening chronotype; BRCA cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg04450456 chr4:17643702 FAM184B 0.38 11.2 0.41 9.94e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10465746 0.780 rs7529293 chr1:84331981 A/G cg10977910 chr1:84465055 TTLL7 0.57 11.95 0.43 7.86e-30 Obesity-related traits; BRCA cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg05084668 chr3:125655381 ALG1L -0.47 -7.98 -0.3 6.69e-15 Blood pressure (smoking interaction); BRCA cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.43 -0.38 1.21e-23 Psoriasis; BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -7.89 -0.3 1.35e-14 Developmental language disorder (linguistic errors); BRCA cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg17330251 chr7:94953956 PON1 0.41 8.24 0.31 9.91e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs12541635 0.966 rs7812766 chr8:107057033 G/A cg10147462 chr8:107024639 NA 0.37 9.78 0.36 3.84e-21 Age of smoking initiation; BRCA cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 8.71e-23 Psoriasis; BRCA cis rs6570726 0.935 rs387965 chr6:145869366 A/G cg23711669 chr6:146136114 FBXO30 0.62 14.47 0.5 2.94e-41 Lobe attachment (rater-scored or self-reported); BRCA trans rs1941687 0.509 rs7230319 chr18:31321289 A/T cg27147174 chr7:100797783 AP1S1 -0.45 -8.84 -0.33 8.89e-18 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs4730250 0.595 rs7789500 chr7:106915723 A/C cg02696742 chr7:106810147 HBP1 -0.47 -7.91 -0.3 1.1e-14 Osteoarthritis; BRCA cis rs9300255 0.739 rs12824957 chr12:123750228 T/C cg00376283 chr12:123451042 ABCB9 -0.56 -10.78 -0.39 5.39e-25 Neutrophil percentage of white cells; BRCA cis rs6088813 0.767 rs4911179 chr20:33972899 A/C cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.1e-17 Height; BRCA trans rs8073060 0.586 rs7221203 chr17:34015532 T/C cg19694781 chr19:47549865 TMEM160 -1.04 -21.05 -0.64 4.18e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA trans rs11098499 0.954 rs13113483 chr4:120309039 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs7258465 0.931 rs271626 chr19:18627067 C/T cg01065977 chr19:18549689 ISYNA1 0.28 8.26 0.31 8.45e-16 Breast cancer; BRCA cis rs3760982 0.585 rs11673534 chr19:44298884 G/A cg11993925 chr19:44307056 LYPD5 0.38 8.98 0.33 3e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs875971 1.000 rs4718344 chr7:65874381 C/A cg11764359 chr7:65958608 NA 0.8 19.49 0.61 9.4e-67 Aortic root size; BRCA trans rs208520 0.690 rs12213575 chr6:66735989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.74 0.63 1.96e-73 Exhaled nitric oxide output; BRCA cis rs6893300 0.776 rs55868831 chr5:179157296 T/C cg14593053 chr5:179126677 CANX -0.35 -7.9 -0.3 1.19e-14 Resting heart rate; BRCA cis rs713587 0.520 rs512419 chr2:25310155 G/T cg01884057 chr2:25150051 NA -0.32 -8.39 -0.32 3.04e-16 Body mass index in non-asthmatics; BRCA trans rs1459104 1.000 rs12577269 chr11:55062905 C/T cg03929089 chr4:120376271 NA 0.64 7.84 0.3 1.95e-14 Body mass index; BRCA cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.66 0.36 1.07e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11677370 0.561 rs11687254 chr2:3830906 C/T cg17052675 chr2:3827356 NA -0.59 -14.89 -0.51 2.84e-43 Type 2 diabetes; BRCA cis rs1467026 0.691 rs9985266 chr3:12803162 C/T cg24848339 chr3:12840334 CAND2 -0.36 -9.09 -0.34 1.19e-18 P wave duration; BRCA cis rs1997103 1.000 rs6958022 chr7:55397389 G/A cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6570726 0.791 rs6570694 chr6:145911204 C/G cg23711669 chr6:146136114 FBXO30 0.73 17.3 0.56 2.77e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs113084984 0.816 rs4669749 chr2:11692664 A/C cg07314298 chr2:11723111 GREB1 -0.39 -7.97 -0.3 7.08e-15 Breast cancer; BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg18402987 chr7:1209562 NA 0.85 12.24 0.44 4.4e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs7980799 0.682 rs7303356 chr12:33633599 C/G cg26384229 chr12:38710491 ALG10B -0.4 -9.04 -0.34 1.88e-18 Heart rate;Heart rate variability traits (RMSSD); BRCA trans rs9951602 0.512 rs9946115 chr18:76654531 A/C cg02800362 chr5:177631904 HNRNPAB 0.78 18.3 0.59 1.73e-60 Obesity-related traits; BRCA cis rs6570726 0.935 rs406343 chr6:145874388 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.79 0.5 8.81e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs1577917 1.000 rs6923148 chr6:86767786 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.42 11.28 0.41 4.93e-27 Response to antipsychotic treatment; BRCA cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.93e-16 Aortic root size; BRCA cis rs1011018 0.628 rs76486291 chr7:139473684 T/C cg03224163 chr7:139420300 HIPK2 -0.59 -8.92 -0.33 5.04e-18 Systolic blood pressure; BRCA cis rs7769051 0.522 rs3736725 chr6:133095172 A/G cg22852734 chr6:133119734 C6orf192 0.9 13.42 0.47 2.44e-36 Type 2 diabetes nephropathy; BRCA cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg11058730 chr11:34937778 PDHX;APIP 0.71 16.86 0.55 4.78e-53 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg05552183 chr6:42928497 GNMT -0.7 -16.05 -0.54 6.07e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg00484396 chr16:3507460 NAT15 0.47 10.24 0.38 6.96e-23 Tuberculosis; BRCA cis rs7131987 0.650 rs6487808 chr12:29463359 C/T cg09582351 chr12:29534625 ERGIC2 0.48 11.17 0.4 1.43e-26 QT interval; BRCA cis rs7267979 0.903 rs2500423 chr20:25374882 G/A cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4853012 0.838 rs12619982 chr2:74356022 G/A cg20891558 chr2:74357851 NA 0.56 12.65 0.45 6.99e-33 Gestational age at birth (maternal effect); BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg23978390 chr7:1156363 C7orf50 0.38 9.24 0.34 3.68e-19 Longevity;Endometriosis; BRCA cis rs636291 0.500 rs655271 chr1:10536635 G/A cg07384165 chr1:10488281 NA -0.41 -8.64 -0.32 4.63e-17 Prostate cancer; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg02353165 chr6:42928485 GNMT 0.76 18.58 0.59 6.18e-62 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6964587 1.000 rs7811873 chr7:91751120 G/A cg17063962 chr7:91808500 NA 0.55 12.92 0.46 4.12e-34 Breast cancer; BRCA cis rs4076764 0.958 rs6688997 chr1:163411562 G/A cg06092702 chr1:163392909 NA -0.36 -9.54 -0.35 2.93e-20 Motion sickness; BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg09877947 chr5:131593287 PDLIM4 0.42 10.8 0.39 4.52e-25 Breast cancer; BRCA cis rs6820391 0.663 rs4864474 chr4:54450380 G/A cg04173182 chr4:54446035 LNX1 0.48 10.82 0.39 3.52e-25 Cervical artery dissection; BRCA trans rs61931739 0.534 rs4547187 chr12:34041259 T/C cg26384229 chr12:38710491 ALG10B 0.51 11.2 0.41 1.05e-26 Morning vs. evening chronotype; BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.54 -0.32 9.88e-17 Total body bone mineral density; BRCA trans rs3857536 0.813 rs7768944 chr6:66951088 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs9487051 0.735 rs455839 chr6:109524221 G/A cg01475377 chr6:109611718 NA -0.44 -11.14 -0.4 1.86e-26 Reticulocyte fraction of red cells; BRCA cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.65 0.32 4.14e-17 Motion sickness; BRCA cis rs6456156 0.586 rs12203510 chr6:167473006 C/T cg07741184 chr6:167504864 NA 0.31 9.4 0.35 9.86e-20 Primary biliary cholangitis; BRCA cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg24110177 chr3:50126178 RBM5 -0.52 -15.3 -0.52 2.97e-45 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg24642439 chr20:33292090 TP53INP2 0.55 12.15 0.43 1.06e-30 Coronary artery disease; BRCA cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg20908204 chr19:46285434 DMPK -0.29 -8.56 -0.32 8.36e-17 Coronary artery disease; BRCA cis rs514406 0.505 rs7543239 chr1:53162416 A/G cg24675658 chr1:53192096 ZYG11B -0.61 -14.1 -0.49 1.63e-39 Monocyte count; BRCA cis rs919433 0.679 rs6737060 chr2:198524885 G/C cg00792783 chr2:198669748 PLCL1 0.39 9.03 0.34 2.08e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg08132940 chr7:1081526 C7orf50 -0.49 -7.87 -0.3 1.47e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4803468 0.763 rs17318596 chr19:41937095 A/G cg09537434 chr19:41945824 ATP5SL -0.99 -22.6 -0.67 1.4e-83 Height; BRCA trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21659725 chr3:3221576 CRBN 0.5 12.62 0.45 9.62e-33 Intelligence (multi-trait analysis); BRCA cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg23992470 chr4:843637 GAK 0.5 8.04 0.3 4.48e-15 Intelligence (multi-trait analysis); BRCA cis rs7605378 0.528 rs1704191 chr2:200816393 C/A cg23649088 chr2:200775458 C2orf69 0.72 15.81 0.53 9.7e-48 Osteoporosis; BRCA cis rs1005277 0.505 rs10827835 chr10:38150709 G/A cg00409905 chr10:38381863 ZNF37A 0.49 10.49 0.38 7.43e-24 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg08470875 chr2:26401718 FAM59B 0.77 11.99 0.43 4.89e-30 Gut microbiome composition (summer); BRCA cis rs2882667 0.931 rs1433009 chr5:138333784 G/A cg04439458 chr5:138467593 SIL1 -0.36 -10.09 -0.37 2.58e-22 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7809950 0.817 rs2237671 chr7:107131528 A/T cg23024343 chr7:107201750 COG5 -0.5 -10.61 -0.39 2.38e-24 Coronary artery disease; BRCA cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg11764359 chr7:65958608 NA -0.67 -14.79 -0.51 8.34e-43 Aortic root size; BRCA cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6430585 0.941 rs7589832 chr2:136504101 A/C cg07169764 chr2:136633963 MCM6 0.99 20.06 0.62 8.32e-70 Corneal structure; BRCA cis rs7134594 0.677 rs9668180 chr12:109860597 T/G cg01703884 chr12:109878174 MYO1H -0.35 -7.87 -0.3 1.49e-14 HDL cholesterol; BRCA cis rs6089584 0.927 rs1886007 chr20:60581049 G/A cg06108461 chr20:60628389 TAF4 -0.77 -16.73 -0.55 2.37e-52 Body mass index; BRCA cis rs861020 1.000 rs632746 chr1:209982515 C/T cg05527609 chr1:210001259 C1orf107 0.7 15.04 0.51 5.66e-44 Orofacial clefts; BRCA cis rs9612 1.000 rs347519 chr19:44273516 T/C cg08581076 chr19:44259116 C19orf61 0.48 8.98 0.33 3.08e-18 Exhaled nitric oxide output; BRCA cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs2243480 1.000 rs316304 chr7:65616894 T/C cg18252515 chr7:66147081 NA -1.04 -15.49 -0.52 3.67e-46 Diabetic kidney disease; BRCA cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg23173402 chr1:227635558 NA 0.53 9.6 0.36 1.78e-20 Major depressive disorder; BRCA cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg15448220 chr1:150897856 SETDB1 0.37 8.35 0.31 4.25e-16 Melanoma; BRCA cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg20503657 chr10:835505 NA 1.05 18.79 0.6 4.85e-63 Eosinophil percentage of granulocytes; BRCA trans rs1973993 0.561 rs1475173 chr1:96993374 C/A cg10631902 chr5:14652156 NA -0.41 -10.05 -0.37 3.59e-22 Weight; BRCA cis rs1005277 0.522 rs7090858 chr10:38003670 A/C cg00409905 chr10:38381863 ZNF37A 0.48 10.27 0.38 5.47e-23 Extrinsic epigenetic age acceleration; BRCA cis rs13190036 1.000 rs13157667 chr5:176613877 C/T cg06733329 chr5:176740039 MXD3 0.46 8.28 0.31 6.96e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg20503657 chr10:835505 NA 1.01 17.47 0.57 3.73e-56 Eosinophil percentage of granulocytes; BRCA cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs9814567 1.000 rs2370642 chr3:134222136 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.89e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4713118 0.955 rs9468206 chr6:27690453 G/T cg20933634 chr6:27740509 NA 0.43 8.48 0.32 1.53e-16 Parkinson's disease; BRCA cis rs701145 0.585 rs1727954 chr3:153871272 T/A cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs17270561 0.609 rs9356985 chr6:25728098 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg22920501 chr2:26401640 FAM59B -0.91 -16.26 -0.54 5.23e-50 Gut microbiome composition (summer); BRCA cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.47 -10.29 -0.38 4.29e-23 Alzheimer's disease (late onset); BRCA cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg08000102 chr2:233561755 GIGYF2 -0.62 -13.97 -0.48 6.75e-39 Coronary artery disease; BRCA cis rs7512552 0.839 rs698919 chr1:150387000 A/G cg15654264 chr1:150340011 RPRD2 0.37 8.17 0.31 1.62e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg08917208 chr2:24149416 ATAD2B 1.09 15.57 0.52 1.48e-46 Lymphocyte counts; BRCA cis rs3820928 1.000 rs10167422 chr2:227777554 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.49 -0.32 1.47e-16 Pulmonary function; BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg08470875 chr2:26401718 FAM59B -0.52 -8.34 -0.31 4.48e-16 Gut microbiome composition (summer); BRCA cis rs4074536 0.574 rs10754349 chr1:116291876 C/T cg21648376 chr1:116311395 CASQ2 -0.5 -8.72 -0.33 2.4e-17 QRS duration; BRCA cis rs853679 0.517 rs9468286 chr6:28079428 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA cis rs1003719 0.788 rs4817845 chr21:38447132 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.25 0.49 3.17e-40 Eye color traits; BRCA cis rs477692 0.699 rs528549 chr10:131381574 A/G cg24747557 chr10:131355152 MGMT -0.36 -8.86 -0.33 7.82e-18 Response to temozolomide; BRCA cis rs3857536 0.740 rs4710574 chr6:66890631 T/G cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs1577917 0.958 rs10455448 chr6:86533611 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.62 -0.42 1.85e-28 Response to antipsychotic treatment; BRCA cis rs62158211 0.691 rs1964463 chr2:114069021 C/T cg17784749 chr2:114082611 LOC440839 -0.52 -9.36 -0.35 1.36e-19 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; BRCA cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 13.81 0.48 3.8e-38 Hip circumference adjusted for BMI; BRCA cis rs4595586 0.545 rs2388174 chr12:39389237 G/A cg26384229 chr12:38710491 ALG10B 0.41 9.1 0.34 1.18e-18 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.75e-15 Developmental language disorder (linguistic errors); BRCA cis rs11809207 0.501 rs3762460 chr1:26495550 A/G cg00147160 chr1:26503991 CNKSR1 0.24 7.88 0.3 1.46e-14 Height; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg23708337 chr7:1209742 NA 0.68 10.7 0.39 1.13e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg13628971 chr7:2884303 GNA12 0.49 9.93 0.37 1.08e-21 Height; BRCA cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg05147244 chr20:61493195 TCFL5 -0.82 -11.23 -0.41 7.52e-27 Obesity-related traits; BRCA cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg19077165 chr18:44547161 KATNAL2 -0.39 -8.25 -0.31 9.35e-16 Educational attainment; BRCA cis rs7666738 0.791 rs7660866 chr4:98961335 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6867032 0.527 rs4975790 chr5:2010376 C/T cg26168224 chr5:2018326 NA 0.44 11.66 0.42 1.33e-28 Gut microbiome composition (winter); BRCA cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg23018236 chr17:30244563 NA -0.45 -8.23 -0.31 1.07e-15 Hip circumference adjusted for BMI; BRCA cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.91 0.33 5.35e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3771570 0.901 rs62190413 chr2:242417950 G/A cg21155796 chr2:242212141 HDLBP 0.62 9.56 0.35 2.44e-20 Prostate cancer; BRCA cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg13319975 chr6:146136371 FBXO30 0.42 9.76 0.36 4.71e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs1994135 0.692 rs7958788 chr12:33692179 T/C cg26384229 chr12:38710491 ALG10B 0.4 8.6 0.32 6.3e-17 Resting heart rate; BRCA cis rs798554 0.704 rs798531 chr7:2770067 G/C cg18446336 chr7:2847575 GNA12 -0.35 -8.09 -0.3 3.03e-15 Height; BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg00908189 chr16:619842 PIGQ 0.69 17.41 0.57 7.16e-56 Height; BRCA cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg11890956 chr21:40555474 PSMG1 -0.61 -13.14 -0.46 4.2e-35 Menarche (age at onset); BRCA trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg13010199 chr12:38710504 ALG10B 0.51 9.89 0.36 1.45e-21 Morning vs. evening chronotype; BRCA cis rs34779708 0.931 rs3740083 chr10:35320383 C/T cg03585969 chr10:35415529 CREM 0.49 10.29 0.38 4.39e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg24812749 chr6:127587940 RNF146 0.88 20.56 0.63 1.81e-72 Breast cancer; BRCA cis rs6761276 0.866 rs12469822 chr2:113830563 C/T cg02302587 chr2:113829866 IL1F10 0.38 8.13 0.31 2.25e-15 Protein quantitative trait loci; BRCA trans rs2204008 0.774 rs7304438 chr12:38361146 T/G cg06521331 chr12:34319734 NA -0.46 -8.52 -0.32 1.16e-16 Bladder cancer; BRCA cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg16109817 chr1:16162209 FLJ37453 -0.29 -8.11 -0.31 2.6e-15 Systolic blood pressure; BRCA cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg04455712 chr21:45112962 RRP1B 0.42 10.91 0.4 1.52e-25 Mean corpuscular volume; BRCA cis rs3820928 0.874 rs1114562 chr2:227788592 T/C cg11843606 chr2:227700838 RHBDD1 -0.39 -8.62 -0.32 5.09e-17 Pulmonary function; BRCA trans rs1422110 0.543 rs768240 chr5:85420954 C/T cg01787110 chr1:109008453 NBPF6 -0.45 -9.99 -0.37 6.43e-22 Attention function in attention deficit hyperactive disorder; BRCA cis rs2742234 1.000 rs1864399 chr10:43610455 T/C cg15436174 chr10:43711423 RASGEF1A -0.43 -8.94 -0.33 4.08e-18 Hirschsprung disease; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.33 -0.54 2.28e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11039798 0.777 rs2202454 chr11:49011009 T/C cg15704280 chr7:45808275 SEPT13 0.6 8.92 0.33 5.03e-18 Axial length; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.67 13.86 0.48 2.19e-38 Lymphocyte counts; BRCA cis rs68170813 0.559 rs114221457 chr7:107019913 C/G cg02696742 chr7:106810147 HBP1 -0.5 -7.91 -0.3 1.17e-14 Coronary artery disease; BRCA trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg13010199 chr12:38710504 ALG10B 0.43 9.12 0.34 9.85e-19 Morning vs. evening chronotype; BRCA cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.22 -0.34 4.3e-19 Menopause (age at onset); BRCA cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08704250 chr15:31115839 NA 0.36 8.98 0.33 2.93e-18 Huntington's disease progression; BRCA cis rs12347191 0.500 rs907579 chr9:100622723 G/T cg13688889 chr9:100608707 NA -0.48 -9.76 -0.36 4.62e-21 Orofacial clefts; BRCA cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg18512352 chr11:47633146 NA -0.33 -7.98 -0.3 6.68e-15 Subjective well-being; BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.89 -0.43 1.38e-29 Gut microbiome composition (summer); BRCA cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg19729930 chr2:74357872 NA -0.54 -12.17 -0.43 8.23e-31 Gestational age at birth (maternal effect); BRCA cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg02187348 chr16:89574699 SPG7 0.49 11.81 0.42 3.01e-29 Multiple myeloma (IgH translocation); BRCA trans rs2262909 0.962 rs408687 chr19:22231123 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -7.98 -0.3 6.96e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs13046373 0.535 rs2226377 chr21:32031915 T/C cg16431978 chr21:31797932 KRTAP13-3 0.36 8.81 0.33 1.2e-17 HDL cholesterol; BRCA cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg23711669 chr6:146136114 FBXO30 -0.81 -19.47 -0.61 1.23e-66 Lobe attachment (rater-scored or self-reported); BRCA trans rs629535 0.547 rs72654095 chr8:70120770 A/G cg21567404 chr3:27674614 NA -0.93 -17.83 -0.58 5.03e-58 Dupuytren's disease; BRCA cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.07 -0.3 3.57e-15 Developmental language disorder (linguistic errors); BRCA cis rs8062405 0.755 rs62034350 chr16:28562256 A/G cg16576597 chr16:28551801 NUPR1 0.35 9.67 0.36 9.93e-21 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7819412 0.540 rs2409725 chr8:11041661 T/C cg21775007 chr8:11205619 TDH -0.5 -10.14 -0.37 1.69e-22 Triglycerides; BRCA trans rs629535 0.773 rs686683 chr8:70070364 G/A cg21567404 chr3:27674614 NA 1.01 20.96 0.64 1.2e-74 Dupuytren's disease; BRCA cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg26149184 chr10:133730230 NA 0.41 8.3 0.31 5.97e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg11663144 chr21:46675770 NA -0.64 -15.28 -0.52 3.69e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4906332 1.000 rs17617832 chr14:103943140 T/C cg19000871 chr14:103996768 TRMT61A -0.35 -8.04 -0.3 4.21e-15 Coronary artery disease; BRCA cis rs826838 1.000 rs851934 chr12:39104453 G/T cg13010199 chr12:38710504 ALG10B -0.42 -9.82 -0.36 2.7e-21 Heart rate; BRCA cis rs600231 0.508 rs11227201 chr11:65242548 G/A cg01292856 chr11:65242576 NA 0.66 14.84 0.51 5.26e-43 Bone mineral density; BRCA cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.4 0.57 8.98e-56 Bladder cancer; BRCA trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.91 -0.3 1.11e-14 Corneal astigmatism; BRCA cis rs3733585 0.673 rs4292332 chr4:9953830 C/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.53e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs11098499 0.820 rs13122709 chr4:120555356 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.39 0.32 3.04e-16 Corneal astigmatism; BRCA cis rs7246657 0.943 rs6508733 chr19:38000548 A/T cg23950597 chr19:37808831 NA -0.62 -11.29 -0.41 4.33e-27 Coronary artery calcification; BRCA cis rs12135062 0.851 rs2651925 chr1:3101863 C/G cg00254258 chr1:3105189 PRDM16 0.45 10.64 0.39 1.83e-24 Migraine; BRCA cis rs10174077 0.874 rs11892439 chr2:152469858 T/A cg19508488 chr2:152266495 RIF1 0.45 9.32 0.35 1.94e-19 Squamous cell lung carcinoma; BRCA cis rs3096299 0.632 rs4399533 chr16:89539382 G/C cg00750074 chr16:89608354 SPG7 -0.4 -10.88 -0.4 1.99e-25 Multiple myeloma (IgH translocation); BRCA cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg17724175 chr1:150552817 MCL1 0.27 8.84 0.33 9.01e-18 Tonsillectomy; BRCA cis rs7618501 0.633 rs4688690 chr3:50022292 G/A cg24308560 chr3:49941425 MST1R -0.4 -8.54 -0.32 9.6e-17 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg00530320 chr1:46809349 NSUN4 0.45 8.99 0.34 2.76e-18 Menopause (age at onset); BRCA cis rs9381040 0.610 rs2268196 chr6:41021950 C/G cg04346459 chr6:41068666 NFYA;LOC221442 0.45 10.04 0.37 4.15e-22 Alzheimer's disease (late onset); BRCA cis rs4713118 0.513 rs149944 chr6:28002818 C/T cg10876282 chr6:28092338 ZSCAN16 0.41 8.13 0.31 2.17e-15 Parkinson's disease; BRCA cis rs4237845 0.537 rs11172367 chr12:58272486 T/G cg00677455 chr12:58241039 CTDSP2 0.69 16.63 0.55 7.19e-52 Intelligence (multi-trait analysis); BRCA cis rs9902453 0.933 rs7224199 chr17:28523726 G/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.46 11.5 0.41 6.22e-28 Coffee consumption (cups per day); BRCA cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg04719120 chr6:96025338 MANEA 0.52 7.85 0.3 1.74e-14 Behavioural disinhibition (generation interaction); BRCA cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs4409675 0.576 rs6691656 chr1:28221130 C/G cg23691781 chr1:28212827 C1orf38 0.32 11.0 0.4 6.87e-26 Corneal astigmatism; BRCA cis rs244731 0.919 rs12652509 chr5:176626441 A/G cg16006841 chr5:176797999 RGS14 -0.69 -10.95 -0.4 1.08e-25 Urate levels in lean individuals; BRCA cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg10802521 chr3:52805072 NEK4 -0.33 -8.48 -0.32 1.61e-16 Bipolar disorder; BRCA cis rs9527 0.590 rs10786741 chr10:104939182 G/A cg04362960 chr10:104952993 NT5C2 0.44 10.06 0.37 3.34e-22 Arsenic metabolism; BRCA cis rs3125734 0.719 rs1835861 chr10:64056141 T/A cg19640130 chr10:64028056 RTKN2 -0.29 -7.98 -0.3 6.94e-15 Rheumatoid arthritis; BRCA cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg18404041 chr3:52824283 ITIH1 -0.37 -11.3 -0.41 4.19e-27 Bipolar disorder; BRCA trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg27661571 chr11:113659931 NA -0.8 -12.01 -0.43 4.07e-30 Hip circumference adjusted for BMI; BRCA cis rs1975991 0.765 rs6444271 chr3:187955738 G/A cg15417654 chr3:187959138 LPP 0.36 9.37 0.35 1.25e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs877282 1.000 rs11253362 chr10:770979 G/T cg17470449 chr10:769945 NA 0.52 9.01 0.34 2.43e-18 Uric acid levels; BRCA cis rs6570726 0.516 rs9376932 chr6:145729490 T/C cg23711669 chr6:146136114 FBXO30 0.45 9.46 0.35 5.94e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs654950 0.776 rs2759254 chr1:42035683 G/C cg06885757 chr1:42089581 HIVEP3 -0.33 -10.94 -0.4 1.21e-25 Airway imaging phenotypes; BRCA cis rs875971 0.862 rs57866200 chr7:65565392 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.84 -0.3 1.9e-14 Aortic root size; BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 19.57 0.61 3.62e-67 Platelet count; BRCA cis rs2832077 0.943 rs2832106 chr21:30191767 A/G cg24692254 chr21:30365293 RNF160 -0.48 -8.31 -0.31 5.95e-16 Cognitive test performance; BRCA cis rs12142240 0.621 rs13374968 chr1:46843908 T/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.69 -0.36 8.4e-21 Menopause (age at onset); BRCA cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg09184832 chr6:79620586 NA -0.52 -11.41 -0.41 1.44e-27 Intelligence (multi-trait analysis); BRCA cis rs2769264 0.602 rs11204777 chr1:151072049 G/A cg04469105 chr1:151031679 CDC42SE1;MLLT11 -0.47 -8.86 -0.33 7.76e-18 Blood trace element (Cu levels); BRCA cis rs10189230 0.967 rs13026380 chr2:222352715 G/A cg14652038 chr2:222343519 EPHA4 0.46 12.75 0.45 2.57e-33 Urate levels in lean individuals; BRCA cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg20701182 chr2:24300061 SF3B14 0.67 9.86 0.36 1.91e-21 Lymphocyte counts; BRCA cis rs57221529 0.709 rs72706612 chr5:561198 C/T cg20362242 chr5:692897 TPPP 0.52 8.45 0.32 1.92e-16 Lung disease severity in cystic fibrosis; BRCA cis rs701145 0.586 rs181443 chr3:153959028 G/T cg16511985 chr3:153974050 SGEF 0.45 10.33 0.38 3.18e-23 Coronary artery disease; BRCA cis rs7523050 0.643 rs35520362 chr1:109419841 C/T cg08274380 chr1:109419600 GPSM2 1.17 16.64 0.55 6.3e-52 Fat distribution (HIV); BRCA cis rs13136331 0.641 rs2627682 chr4:88662490 A/G cg22416721 chr4:88570574 DMP1 -0.56 -13.31 -0.47 7.43e-36 Sitting height ratio; BRCA cis rs10193935 0.792 rs7559001 chr2:42474301 C/T cg27598129 chr2:42591480 NA -0.62 -10.5 -0.38 6.86e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 0.701 rs12491473 chr3:46989904 G/A cg16586182 chr3:47516702 SCAP 0.52 11.54 0.42 3.92e-28 Colorectal cancer; BRCA cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg06028605 chr16:24865363 SLC5A11 -0.46 -10.07 -0.37 3.22e-22 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.74 -16.26 -0.54 5.33e-50 Lymphocyte counts; BRCA cis rs11722228 1.000 rs6825187 chr4:9915325 T/C cg00071950 chr4:10020882 SLC2A9 -0.4 -8.57 -0.32 7.52e-17 Gout;Urate levels;Serum uric acid levels; BRCA cis rs425277 1.000 rs262647 chr1:2095699 C/T cg00981070 chr1:2046702 PRKCZ 0.31 8.22 0.31 1.09e-15 Height; BRCA cis rs4742903 0.527 rs2122576 chr9:106870187 G/T cg14250997 chr9:106856677 SMC2 -0.28 -8.35 -0.31 4.26e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2108225 0.934 rs4730269 chr7:107455719 T/G cg18560240 chr7:107437656 SLC26A3 -0.49 -9.85 -0.36 2.04e-21 Ulcerative colitis; BRCA cis rs12950390 0.853 rs17700008 chr17:45863591 A/C cg00777063 chr17:45855553 NA 0.29 7.96 0.3 7.9e-15 IgG glycosylation; BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.1 0.31 2.86e-15 Tonsillectomy; BRCA cis rs870825 0.860 rs2696044 chr4:185595988 C/G cg04058563 chr4:185651563 MLF1IP 0.66 11.61 0.42 2.07e-28 Blood protein levels; BRCA cis rs7684253 0.565 rs12641030 chr4:57803505 A/G cg11939399 chr4:57773300 REST 0.29 7.94 0.3 8.96e-15 Migraine; BRCA cis rs400736 0.637 rs2300428 chr1:7996894 A/G cg25007680 chr1:8021821 PARK7 -0.44 -10.82 -0.39 3.51e-25 Response to antidepressants and depression; BRCA cis rs17270561 0.609 rs4711103 chr6:25742224 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs4727027 0.704 rs13229244 chr7:148898219 A/C cg12479418 chr7:148823350 ZNF425;ZNF398 -0.4 -8.2 -0.31 1.3e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg14004847 chr7:1930337 MAD1L1 -0.43 -8.55 -0.32 9.08e-17 Bipolar disorder and schizophrenia; BRCA cis rs926392 0.896 rs742276 chr20:37679849 C/T cg16355469 chr20:37678765 NA 0.32 8.1 0.31 2.77e-15 Dialysis-related mortality; BRCA cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.67 10.44 0.38 1.13e-23 Schizophrenia; BRCA cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg20607287 chr7:12443886 VWDE -0.49 -8.56 -0.32 8.27e-17 Coronary artery disease; BRCA cis rs9814567 1.000 rs10935120 chr3:134233092 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.58 19.19 0.6 3.67e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg10523679 chr1:76189770 ACADM 0.76 15.91 0.53 2.83e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg05347473 chr6:146136440 FBXO30 0.44 8.7 0.33 2.8e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg13114125 chr14:105738426 BRF1 -0.57 -11.81 -0.42 3.01e-29 Mean platelet volume;Platelet distribution width; BRCA cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg16230307 chr14:35515116 FAM177A1 0.73 15.12 0.51 2.22e-44 Psoriasis; BRCA cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg04166393 chr7:2884313 GNA12 0.63 13.77 0.48 5.94e-38 Height; BRCA cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg24110177 chr3:50126178 RBM5 -0.53 -15.92 -0.53 2.64e-48 Body mass index; BRCA cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg09184832 chr6:79620586 NA -0.53 -11.69 -0.42 9.66e-29 Intelligence (multi-trait analysis); BRCA cis rs2249625 0.874 rs1852704 chr6:72880088 C/T cg18830697 chr6:72922368 RIMS1 -0.37 -7.99 -0.3 6.29e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg11584989 chr19:19387371 SF4 0.64 13.49 0.47 1.14e-36 Bipolar disorder; BRCA cis rs698833 0.562 rs10182045 chr2:44704236 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.44 8.89 0.33 6.36e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg14863265 chr7:2801509 GNA12 -0.42 -9.72 -0.36 6.44e-21 Height; BRCA cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.64 0.32 4.45e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs262150 0.567 rs2040897 chr7:158803848 C/T cg23096020 chr7:158799433 NA -0.36 -8.56 -0.32 8.35e-17 Facial morphology (factor 20); BRCA trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7555523 1.000 rs7555523 chr1:165718979 C/A cg24409356 chr1:165738333 TMCO1 0.5 8.33 0.31 4.9e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg12444411 chr7:2802554 GNA12 -0.38 -9.4 -0.35 9.34e-20 Height; BRCA trans rs7726839 0.561 rs72703044 chr5:579737 G/A cg25482853 chr8:67687455 SGK3 0.78 13.07 0.46 8.85e-35 Obesity-related traits; BRCA cis rs344364 0.511 rs337286 chr16:1965719 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.65 -10.77 -0.39 5.68e-25 Glomerular filtration rate in chronic kidney disease; BRCA cis rs2070488 0.896 rs11914389 chr3:38527215 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 19.2 0.6 3.47e-65 Electrocardiographic conduction measures; BRCA trans rs1994135 0.669 rs11052746 chr12:33697473 A/C cg26384229 chr12:38710491 ALG10B -0.39 -8.56 -0.32 8.51e-17 Resting heart rate; BRCA cis rs2070488 0.965 rs2051216 chr3:38562288 C/T cg24069376 chr3:38537580 EXOG -0.42 -12.04 -0.43 3.26e-30 Electrocardiographic conduction measures; BRCA cis rs9467773 0.583 rs1021373 chr6:26632457 G/A cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs13051135 chr21:32005278 G/A cg14062083 chr21:31802829 KRTAP13-4 0.34 9.37 0.35 1.28e-19 HDL cholesterol; BRCA cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg26384229 chr12:38710491 ALG10B 0.69 16.15 0.54 1.9e-49 Bladder cancer; BRCA cis rs7945718 0.839 rs11022511 chr11:12834638 A/T cg25843174 chr11:12811716 TEAD1 0.23 8.62 0.32 5.11e-17 Educational attainment (years of education); BRCA trans rs7618501 1.000 rs4855862 chr3:49748833 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.8 -0.65 3.28e-79 Intelligence (multi-trait analysis); BRCA cis rs8177179 0.967 rs4994581 chr3:133437563 T/C cg24879335 chr3:133465180 TF 0.32 10.83 0.39 3.36e-25 Iron status biomarkers (transferrin levels); BRCA cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg23711669 chr6:146136114 FBXO30 -0.78 -18.2 -0.58 6.16e-60 Lobe attachment (rater-scored or self-reported); BRCA cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg15145296 chr3:125709740 NA -0.53 -8.83 -0.33 1.04e-17 Blood pressure (smoking interaction); BRCA cis rs7264396 0.563 rs6058322 chr20:34367277 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.67 11.56 0.42 3.46e-28 Total cholesterol levels; BRCA cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg01579765 chr21:45077557 HSF2BP -0.35 -9.38 -0.35 1.11e-19 Mean corpuscular volume; BRCA cis rs7267979 1.000 rs6115191 chr20:25440478 C/T cg08601574 chr20:25228251 PYGB 0.36 8.37 0.31 3.65e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6545883 1.000 rs6742276 chr2:61768745 G/A cg15711740 chr2:61764176 XPO1 -0.55 -14.11 -0.49 1.49e-39 Tuberculosis; BRCA cis rs9527 0.590 rs3781281 chr10:104852648 A/G cg04362960 chr10:104952993 NT5C2 -0.47 -11.2 -0.4 1.07e-26 Arsenic metabolism; BRCA cis rs847577 0.748 rs13221897 chr7:97719699 G/A cg24562669 chr7:97807699 LMTK2 0.62 18.68 0.59 1.8e-62 Breast cancer; BRCA cis rs7666738 0.830 rs7686456 chr4:99019695 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.92 0.4 1.39e-25 Cognitive ability; BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg27478167 chr7:817139 HEATR2 -0.55 -11.11 -0.4 2.39e-26 Cerebrospinal P-tau181p levels; BRCA trans rs12517041 1.000 rs71611219 chr5:23280981 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.85 -0.3 1.72e-14 Calcium levels; BRCA trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg25206134 chr2:45395956 NA 0.55 9.06 0.34 1.56e-18 Bipolar disorder; BRCA trans rs11098499 0.874 rs10022508 chr4:120115228 A/G cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.8e-24 Corneal astigmatism; BRCA cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg08885076 chr2:99613938 TSGA10 0.42 9.8 0.36 3.11e-21 Chronic sinus infection; BRCA cis rs7592578 0.771 rs4439990 chr2:191398353 A/C cg11845111 chr2:191398756 TMEM194B -0.81 -15.47 -0.52 4.54e-46 Diastolic blood pressure; BRCA trans rs6461049 0.765 rs10224497 chr7:2149967 A/G cg04565464 chr8:145669602 NFKBIL2 0.38 9.35 0.35 1.42e-19 Schizophrenia; BRCA cis rs77633900 0.614 rs280028 chr15:77031466 A/G cg21673338 chr15:77095150 SCAPER -0.53 -9.72 -0.36 6.2e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs10771431 0.597 rs3759274 chr12:9353875 T/C cg08997352 chr12:9597637 DDX12 -0.54 -10.21 -0.37 8.78e-23 Breast size; BRCA trans rs35110281 0.782 rs7282933 chr21:45046988 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.43 0.38 1.27e-23 Mean corpuscular volume; BRCA cis rs4953076 0.573 rs920519 chr2:44452344 T/C cg04920474 chr2:44395004 PPM1B 0.51 10.6 0.39 2.83e-24 Height; BRCA cis rs13064411 0.542 rs4396864 chr3:113212562 C/T cg18753928 chr3:113234510 CCDC52 -0.46 -9.87 -0.36 1.81e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7618915 0.571 rs67539070 chr3:52711974 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 3.02e-25 Bipolar disorder; BRCA cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg01448562 chr3:133502909 NA -0.37 -8.54 -0.32 9.9e-17 Iron status biomarkers; BRCA cis rs8180040 0.654 rs6766230 chr3:47196209 C/A cg16586182 chr3:47516702 SCAP -0.56 -12.49 -0.44 3.39e-32 Colorectal cancer; BRCA cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg24558204 chr6:135376177 HBS1L 0.59 15.6 0.53 1.04e-46 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg23978390 chr7:1156363 C7orf50 0.44 10.15 0.37 1.53e-22 Longevity;Endometriosis; BRCA cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg05347473 chr6:146136440 FBXO30 -0.42 -8.37 -0.31 3.58e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg00677455 chr12:58241039 CTDSP2 -0.4 -9.39 -0.35 1.06e-19 Multiple sclerosis; BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -11.57 -0.42 3.12e-28 Gut microbiome composition (summer); BRCA cis rs780096 0.587 rs4665969 chr2:27574953 C/T cg22903471 chr2:27725779 GCKR 0.35 8.72 0.33 2.46e-17 Total body bone mineral density; BRCA cis rs921968 0.643 rs645796 chr2:219389236 A/G cg02176678 chr2:219576539 TTLL4 0.39 10.47 0.38 8.53e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg26031613 chr14:104095156 KLC1 -0.42 -8.45 -0.32 1.94e-16 Schizophrenia; BRCA cis rs67460515 0.892 rs10513564 chr3:161059762 A/G cg03342759 chr3:160939853 NMD3 -0.81 -19.11 -0.6 1.04e-64 Parkinson's disease; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -13.23 -0.46 1.8e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs7647973 0.626 rs2329021 chr3:49679072 G/A cg21659725 chr3:3221576 CRBN -0.47 -8.44 -0.32 2.17e-16 Menarche (age at onset); BRCA cis rs72772090 0.539 rs116360011 chr5:96117797 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.12 -0.43 1.37e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.27 -0.49 2.7e-40 Platelet count; BRCA cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.77 16.24 0.54 6.44e-50 Smoking behavior; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg07308232 chr7:1071921 C7orf50 -0.51 -10.65 -0.39 1.72e-24 Longevity;Endometriosis; BRCA cis rs1005277 0.579 rs2474574 chr10:38387295 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA cis rs875971 0.929 rs6970860 chr7:65976634 A/G cg18876405 chr7:65276391 NA 0.55 12.96 0.46 2.73e-34 Aortic root size; BRCA cis rs9291683 0.610 rs993173 chr4:10323935 T/C cg00071950 chr4:10020882 SLC2A9 -0.41 -9.74 -0.36 5.42e-21 Bone mineral density; BRCA cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.63 -0.32 4.78e-17 Developmental language disorder (linguistic errors); BRCA cis rs6842047 1.000 rs4862668 chr4:187136443 A/T cg23442198 chr4:187126114 CYP4V2 0.65 8.93 0.33 4.4e-18 Blood protein levels; BRCA cis rs12118280 0.581 rs545593 chr1:108720242 G/A cg11967332 chr1:108735228 SLC25A24 -0.54 -10.18 -0.37 1.2e-22 Myeloid white cell count; BRCA cis rs1468333 0.964 rs2967785 chr5:137543713 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.23 0.34 4.04e-19 Resting heart rate; BRCA cis rs11711311 0.911 rs28577577 chr3:113447276 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs7131987 0.650 rs3782509 chr12:29453778 G/A cg09582351 chr12:29534625 ERGIC2 -0.46 -10.78 -0.39 5.18e-25 QT interval; BRCA cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs17685 0.753 rs13240404 chr7:75675719 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.4 8.97 0.33 3.13e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg22903471 chr2:27725779 GCKR -0.39 -9.33 -0.35 1.71e-19 Total body bone mineral density; BRCA cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 8.1 0.3 2.89e-15 Diabetic retinopathy; BRCA cis rs782590 0.934 rs62165184 chr2:55788253 G/C cg18811423 chr2:55921094 PNPT1 0.71 22.68 0.67 5.59e-84 Metabolic syndrome; BRCA cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg20607287 chr7:12443886 VWDE -0.54 -8.16 -0.31 1.83e-15 Coronary artery disease; BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.68 0.39 1.28e-24 Tonsillectomy; BRCA cis rs9733 0.687 rs12410050 chr1:150857141 A/G cg13175981 chr1:150552382 MCL1 0.42 9.34 0.35 1.54e-19 Tonsillectomy; BRCA cis rs10870270 1.000 rs10870292 chr10:133770782 G/C cg08754478 chr10:133766260 PPP2R2D -0.69 -14.06 -0.49 2.48e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1595825 0.891 rs6733834 chr2:198518709 C/G cg19156104 chr2:198669113 PLCL1 0.42 7.99 0.3 6.48e-15 Ulcerative colitis; BRCA cis rs17376456 0.877 rs10476597 chr5:93367172 C/T cg25358565 chr5:93447407 FAM172A -1.23 -18.94 -0.6 7.57e-64 Diabetic retinopathy; BRCA cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg11657440 chr19:46296263 DMWD -0.57 -13.56 -0.47 5.49e-37 Coronary artery disease; BRCA cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.36 -8.47 -0.32 1.67e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg24110177 chr3:50126178 RBM5 0.37 10.05 0.37 3.74e-22 Intelligence (multi-trait analysis); BRCA cis rs875971 0.528 rs801213 chr7:66014918 C/T cg11764359 chr7:65958608 NA -0.64 -11.45 -0.41 9.95e-28 Aortic root size; BRCA cis rs10056811 0.538 rs56174528 chr5:74400516 G/C cg19683494 chr5:74908142 NA 0.56 8.48 0.32 1.53e-16 Coronary artery disease; BRCA cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg21132104 chr15:45694354 SPATA5L1 0.61 11.88 0.43 1.44e-29 Homoarginine levels; BRCA cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg26597838 chr10:835615 NA 0.92 14.37 0.49 8.81e-41 Eosinophil percentage of granulocytes; BRCA cis rs939658 0.805 rs35462901 chr15:79442201 C/T cg17916960 chr15:79447300 NA -0.43 -10.98 -0.4 8.11e-26 Refractive error; BRCA cis rs11887277 0.513 rs13016313 chr2:27045207 C/A cg12368169 chr2:27073192 DPYSL5 -0.28 -8.07 -0.3 3.5e-15 Obesity-related traits; BRCA cis rs6060717 0.536 rs11697851 chr20:34524494 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.03 -0.3 4.56e-15 Hip circumference adjusted for BMI; BRCA cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg20503657 chr10:835505 NA 1.01 17.75 0.57 1.28e-57 Eosinophil percentage of granulocytes; BRCA cis rs9942416 0.660 rs34905687 chr5:74997736 A/G cg19683494 chr5:74908142 NA 0.49 9.11 0.34 1.09e-18 Age-related disease endophenotypes; BRCA cis rs208520 0.690 rs12192710 chr6:66718137 C/T cg07460842 chr6:66804631 NA 0.98 19.59 0.61 2.75e-67 Exhaled nitric oxide output; BRCA cis rs919433 0.653 rs700651 chr2:198631714 G/A cg00792783 chr2:198669748 PLCL1 0.46 9.95 0.37 9.06e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.07 0.3 3.54e-15 Parkinson's disease; BRCA cis rs16866061 0.517 rs7580488 chr2:225473263 C/T cg12698349 chr2:225449008 CUL3 0.45 11.11 0.4 2.39e-26 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg18225595 chr11:63971243 STIP1 0.49 8.57 0.32 7.88e-17 Mean platelet volume; BRCA cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg16405210 chr4:1374714 KIAA1530 -0.53 -12.51 -0.44 2.91e-32 Longevity; BRCA trans rs4689592 0.503 rs56099074 chr4:7071259 A/G cg07817883 chr1:32538562 TMEM39B 0.47 7.91 0.3 1.12e-14 Monocyte percentage of white cells; BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg10729496 chr3:10149963 C3orf24 0.42 8.09 0.3 2.94e-15 Alzheimer's disease; BRCA cis rs7584330 0.554 rs880931 chr2:238396741 G/A cg08992911 chr2:238395768 MLPH 0.64 10.76 0.39 6.08e-25 Prostate cancer; BRCA cis rs735860 0.718 rs209488 chr6:53177540 A/T cg10236188 chr6:53219634 NA 0.38 7.98 0.3 6.78e-15 Glaucoma; BRCA cis rs6831352 0.879 rs2602879 chr4:100040652 G/A cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Alcohol dependence; BRCA trans rs2562456 0.917 rs2562468 chr19:21714850 G/A cg25042112 chr7:64838748 ZNF92 0.46 8.51 0.32 1.27e-16 Pain; BRCA cis rs7917772 0.582 rs4917973 chr10:104333700 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg12444411 chr7:2802554 GNA12 -0.35 -8.61 -0.32 5.85e-17 Height; BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.8 12.09 0.43 1.91e-30 Platelet count; BRCA cis rs72781680 0.898 rs6712524 chr2:24083925 T/C cg20701182 chr2:24300061 SF3B14 0.57 8.95 0.33 3.98e-18 Lymphocyte counts; BRCA cis rs1832871 0.672 rs7750011 chr6:158746802 A/C cg07165851 chr6:158734300 TULP4 0.63 12.61 0.45 9.79e-33 Height; BRCA cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs12478296 1.000 rs57603292 chr2:243028537 G/A cg06360820 chr2:242988706 NA -0.86 -14.99 -0.51 9.3e-44 Obesity-related traits; BRCA cis rs9560113 1.000 rs4773384 chr13:112177987 A/G cg10483660 chr13:112241077 NA 0.32 7.86 0.3 1.65e-14 Menarche (age at onset); BRCA cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg18850127 chr7:39170497 POU6F2 0.54 11.95 0.43 7.84e-30 IgG glycosylation; BRCA trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg23533926 chr12:111358616 MYL2 -0.44 -9.19 -0.34 5.5e-19 Extrinsic epigenetic age acceleration; BRCA cis rs9868809 0.505 rs56735597 chr3:48765168 A/G cg01304814 chr3:48885189 PRKAR2A 0.58 7.99 0.3 6.11e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.83e-16 Developmental language disorder (linguistic errors); BRCA cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.69 12.75 0.45 2.36e-33 Chronic sinus infection; BRCA cis rs870825 0.616 rs28524599 chr4:185647414 A/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs7904368 0.806 rs12242261 chr10:16872929 T/C cg23933602 chr10:16859644 RSU1 0.52 8.29 0.31 6.93e-16 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs1420338 0.967 rs10807873 chr7:34171276 C/T cg01275685 chr7:34179230 BMPER -0.46 -10.08 -0.37 2.71e-22 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg09177884 chr7:1199841 ZFAND2A -0.52 -11.23 -0.41 7.51e-27 Longevity;Endometriosis; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.35 -0.31 4.24e-16 Menopause (age at onset); BRCA trans rs11098499 0.863 rs11933966 chr4:120476715 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg25237894 chr2:233734115 C2orf82 -0.39 -11.02 -0.4 5.58e-26 Coronary artery disease; BRCA cis rs1371867 0.846 rs1788203 chr8:101303721 T/C cg06002616 chr8:101225028 SPAG1 -0.34 -8.38 -0.31 3.33e-16 Atrioventricular conduction; BRCA trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg25482853 chr8:67687455 SGK3 0.97 15.32 0.52 2.31e-45 Lung disease severity in cystic fibrosis; BRCA cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.48e-43 Aortic root size; BRCA cis rs3125734 0.633 rs1873685 chr10:64032126 C/T cg19640130 chr10:64028056 RTKN2 -0.32 -8.89 -0.33 6.2e-18 Rheumatoid arthritis; BRCA cis rs10985070 0.504 rs2296077 chr9:123944943 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.39 8.24 0.31 9.46e-16 Rheumatoid arthritis; BRCA cis rs514406 1.000 rs514406 chr1:53330458 A/G cg08859206 chr1:53392774 SCP2 -0.48 -9.71 -0.36 6.75e-21 Monocyte count; BRCA cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg15212455 chr7:39170539 POU6F2 0.45 10.0 0.37 5.72e-22 IgG glycosylation; BRCA cis rs7247513 0.964 rs8105902 chr19:12718351 G/A cg01871581 chr19:12707946 ZNF490 -0.69 -15.61 -0.53 9.27e-47 Bipolar disorder; BRCA trans rs3858145 0.588 rs61854833 chr10:70037327 C/G cg04882175 chr6:131122610 NA -0.35 -8.31 -0.31 5.79e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA trans rs9291683 0.595 rs13145442 chr4:10037261 C/A cg26043149 chr18:55253948 FECH 0.42 9.08 0.34 1.33e-18 Bone mineral density; BRCA cis rs9486715 1.000 rs9398148 chr6:97063555 A/G cg06623918 chr6:96969491 KIAA0776 -0.82 -21.97 -0.66 3.93e-80 Headache; BRCA cis rs9287719 0.967 rs728281 chr2:10750355 T/C cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs724568 0.527 rs12612262 chr2:67934125 G/C cg17945962 chr2:67939740 NA -0.37 -9.76 -0.36 4.61e-21 Major depressive disorder (broad); BRCA cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg12756686 chr19:29218302 NA 0.54 9.43 0.35 7.26e-20 Methadone dose in opioid dependence; BRCA cis rs34172651 0.517 rs8059004 chr16:24837905 G/A cg04756594 chr16:24857601 SLC5A11 0.51 11.52 0.41 4.87e-28 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs6860806 0.507 rs635620 chr5:131720263 A/G cg24060327 chr5:131705240 SLC22A5 0.62 11.61 0.42 2.12e-28 Breast cancer; BRCA trans rs12310956 0.532 rs1525904 chr12:33962448 T/C cg26384229 chr12:38710491 ALG10B 0.66 13.95 0.48 8.57e-39 Morning vs. evening chronotype; BRCA cis rs8005677 1.000 rs1956881 chr14:23394069 A/C cg01529538 chr14:23388837 RBM23 0.42 11.45 0.41 9.99e-28 Cognitive ability (multi-trait analysis); BRCA cis rs9914988 0.943 rs4795457 chr17:27087929 C/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.97 -0.33 3.31e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs3780486 0.846 rs10813954 chr9:33137596 A/C cg04842962 chr6:43655489 MRPS18A 1.12 38.92 0.84 9.6e-171 IgG glycosylation; BRCA cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -9.0 -0.34 2.61e-18 Developmental language disorder (linguistic errors); BRCA cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.58 9.04 0.34 1.89e-18 Lung function (FEV1/FVC); BRCA cis rs17401966 0.809 rs12406943 chr1:10308545 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.57 0.47 4.69e-37 Hepatocellular carcinoma; BRCA cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg24549020 chr5:56110836 MAP3K1 0.64 13.06 0.46 9.94e-35 Initial pursuit acceleration; BRCA cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg01939980 chr4:1354348 KIAA1530 0.29 7.84 0.3 1.94e-14 Obesity-related traits; BRCA cis rs849141 0.890 rs849143 chr7:28186473 G/T cg22892036 chr7:28189139 JAZF1 0.47 8.5 0.32 1.29e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.23e-36 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11890956 chr21:40555474 PSMG1 -0.62 -13.7 -0.48 1.18e-37 Menarche (age at onset); BRCA cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg11057378 chr10:81107060 PPIF 0.43 10.22 0.37 8.19e-23 Height; BRCA cis rs4925386 0.840 rs6143034 chr20:60920545 T/C cg06026331 chr20:60912101 LAMA5 0.59 11.93 0.43 9.2e-30 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg03146154 chr1:46216737 IPP 0.47 10.41 0.38 1.44e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs78456975 0.699 rs17091772 chr2:1519679 A/C cg26248373 chr2:1572462 NA -0.51 -10.54 -0.38 4.48e-24 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs875971 0.545 rs73150604 chr7:65945532 T/A cg11764359 chr7:65958608 NA 0.62 10.67 0.39 1.44e-24 Aortic root size; BRCA cis rs28595532 0.623 rs71608363 chr4:119227259 T/C cg21605333 chr4:119757512 SEC24D 0.81 8.48 0.32 1.58e-16 Cannabis dependence symptom count; BRCA cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg11764359 chr7:65958608 NA 0.74 16.57 0.55 1.44e-51 Aortic root size; BRCA cis rs593982 0.920 rs488170 chr11:65481544 T/C cg08755490 chr11:65554678 OVOL1 1.2 17.73 0.57 1.76e-57 Atopic dermatitis; BRCA cis rs9399135 0.844 rs13209789 chr6:135367916 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.66e-31 Red blood cell count; BRCA cis rs4689592 0.503 rs56099074 chr4:7071259 A/G cg19539972 chr4:7069911 GRPEL1 -0.64 -12.74 -0.45 2.68e-33 Monocyte percentage of white cells; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg05863683 chr7:1912471 MAD1L1 -0.38 -8.63 -0.32 4.71e-17 Bipolar disorder and schizophrenia; BRCA cis rs6121246 0.908 rs6089094 chr20:30431771 C/T cg13852791 chr20:30311386 BCL2L1 0.76 14.35 0.49 1.15e-40 Mean corpuscular hemoglobin; BRCA cis rs9811920 0.609 rs10936005 chr3:99674093 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.33 0.31 4.77e-16 Axial length; BRCA cis rs9527 0.590 rs763914 chr10:104841587 T/C cg04362960 chr10:104952993 NT5C2 0.44 9.89 0.36 1.42e-21 Arsenic metabolism; BRCA cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg26597838 chr10:835615 NA 1.03 18.35 0.59 1e-60 Eosinophil percentage of granulocytes; BRCA cis rs67460515 0.563 rs1599388 chr3:160846866 A/G cg17135325 chr3:160939158 NMD3 0.42 7.91 0.3 1.14e-14 Parkinson's disease; BRCA cis rs4499344 0.730 rs417823 chr19:33104561 A/G cg22980127 chr19:33182716 NUDT19 -0.39 -8.49 -0.32 1.45e-16 Mean platelet volume; BRCA cis rs2629540 0.847 rs34032724 chr10:126408869 T/G cg08799069 chr10:126477246 METTL10 0.46 9.34 0.35 1.53e-19 Cocaine dependence; BRCA cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 9.59 0.35 1.87e-20 Rheumatoid arthritis; BRCA cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg08992911 chr2:238395768 MLPH 0.54 8.28 0.31 7.01e-16 Prostate cancer; BRCA cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg25251562 chr2:3704773 ALLC 0.52 9.78 0.36 3.86e-21 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs4363385 0.782 rs10788857 chr1:153024941 T/G cg24667326 chr1:152973720 SPRR3 -0.31 -8.27 -0.31 7.99e-16 Inflammatory skin disease; BRCA cis rs13161895 0.818 rs116463976 chr5:179484519 G/C cg02702477 chr5:179499311 RNF130 0.58 10.11 0.37 2.19e-22 LDL cholesterol; BRCA cis rs6878727 0.850 rs6881377 chr5:123731759 G/A cg01806427 chr5:123737813 NA 0.42 9.72 0.36 6.39e-21 Breast cancer; BRCA cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg06060754 chr5:176797920 RGS14 -0.89 -16.67 -0.55 4.39e-52 Hemoglobin concentration;Hematocrit; BRCA cis rs60843830 0.623 rs55932737 chr2:107543 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.64 0.32 4.61e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4727027 0.704 rs10952805 chr7:148907849 G/A cg23583168 chr7:148888333 NA -0.96 -25.09 -0.7 3.35e-97 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg05665937 chr4:1216051 CTBP1 0.5 10.12 0.37 1.93e-22 Obesity-related traits; BRCA cis rs8114671 0.836 rs6142280 chr20:33622242 A/C cg07148914 chr20:33460835 GGT7 -0.42 -9.07 -0.34 1.44e-18 Height; BRCA cis rs3784262 0.692 rs12914388 chr15:58283843 T/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.86 -0.36 1.97e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg05025164 chr4:1340916 KIAA1530 0.47 10.29 0.38 4.44e-23 Longevity; BRCA cis rs3857067 0.772 rs10018905 chr4:95076767 A/G cg11021082 chr4:95130006 SMARCAD1 -0.38 -8.8 -0.33 1.28e-17 QT interval; BRCA cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg05347473 chr6:146136440 FBXO30 0.39 8.04 0.3 4.22e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg00738919 chr7:1100172 C7orf50 0.46 7.84 0.3 1.94e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7945705 0.818 rs2742552 chr11:8876852 C/T cg12365402 chr11:9010492 NRIP3 -0.39 -9.01 -0.34 2.29e-18 Hemoglobin concentration; BRCA cis rs10046574 0.908 rs28418917 chr7:135124905 T/C cg27474649 chr7:135195673 CNOT4 0.6 8.54 0.32 9.88e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs8017423 0.605 rs3742673 chr14:90735707 C/T cg04374321 chr14:90722782 PSMC1 0.48 11.42 0.41 1.33e-27 Mortality in heart failure; BRCA cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg13010199 chr12:38710504 ALG10B 0.44 8.93 0.33 4.46e-18 Bladder cancer; BRCA cis rs9790314 0.586 rs1811483 chr3:161130900 A/G cg04691961 chr3:161091175 C3orf57 -0.38 -8.49 -0.32 1.43e-16 Morning vs. evening chronotype; BRCA cis rs72720396 1.000 rs72720396 chr1:91191582 A/G cg13456504 chr1:91191583 NA 0.58 10.38 0.38 1.95e-23 Morning vs. evening chronotype;Chronotype; BRCA cis rs2625529 0.761 rs972028 chr15:72173092 C/T cg16672083 chr15:72433130 SENP8 -0.75 -15.97 -0.53 1.53e-48 Red blood cell count; BRCA cis rs1018836 0.923 rs9643308 chr8:91625399 A/C cg16814680 chr8:91681699 NA -0.59 -12.7 -0.45 4.08e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs17092148 0.887 rs6059937 chr20:33186200 G/C cg16810054 chr20:33298113 TP53INP2 -0.47 -10.69 -0.39 1.17e-24 Neuroticism; BRCA trans rs4714291 0.963 rs1767672 chr6:40104107 G/T cg02267698 chr19:7991119 CTXN1 0.43 8.33 0.31 5e-16 Strep throat; BRCA cis rs7607369 0.718 rs6727147 chr2:219639024 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -10.96 -0.4 9.9e-26 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7408868 0.908 rs10416777 chr19:15276923 C/T cg14696996 chr19:15285081 NOTCH3 0.99 14.49 0.5 2.35e-41 Pulse pressure; BRCA cis rs10751667 0.643 rs7395592 chr11:934094 C/G ch.11.42038R chr11:967971 AP2A2 0.5 15.52 0.52 2.5e-46 Alzheimer's disease (late onset); BRCA cis rs11105298 0.891 rs6538189 chr12:89885923 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.97 -0.37 7.48e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7267979 0.966 rs2261720 chr20:25260641 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.85 0.36 2.09e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1003719 0.591 rs1053966 chr21:38568009 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.54 -11.6 -0.42 2.24e-28 Eye color traits; BRCA cis rs6691722 0.506 rs12030365 chr1:24739220 T/A cg18323236 chr1:24743029 NIPAL3 0.37 10.36 0.38 2.33e-23 Response to interferon beta in multiple sclerosis; BRCA cis rs9733 0.596 rs72702573 chr1:150689050 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs9368481 0.729 rs10946881 chr6:26914611 C/T cg12292205 chr6:26970375 C6orf41 0.72 16.32 0.54 2.51e-50 Autism spectrum disorder or schizophrenia; BRCA cis rs2346177 0.605 rs7598712 chr2:46660452 G/T cg26688816 chr2:46740690 ATP6V1E2 -0.38 -8.33 -0.31 5.11e-16 HDL cholesterol; BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg16606324 chr3:10149918 C3orf24 0.53 10.41 0.38 1.54e-23 Alzheimer's disease; BRCA cis rs6740322 0.748 rs6720087 chr2:43468745 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.74 14.4 0.49 6.68e-41 Coronary artery disease; BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg02951883 chr7:2050386 MAD1L1 -0.52 -11.86 -0.42 1.8e-29 Bipolar disorder and schizophrenia; BRCA cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg20891558 chr2:74357851 NA 0.51 12.13 0.43 1.31e-30 Gestational age at birth (maternal effect); BRCA trans rs11098499 0.913 rs10010696 chr4:120164303 T/C cg25214090 chr10:38739885 LOC399744 0.48 10.68 0.39 1.29e-24 Corneal astigmatism; BRCA cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg24130564 chr14:104152367 KLC1 -0.34 -7.86 -0.3 1.63e-14 Body mass index; BRCA cis rs11971779 0.680 rs11980313 chr7:139034643 C/G cg07862535 chr7:139043722 LUC7L2 0.39 10.46 0.38 9.65e-24 Diisocyanate-induced asthma; BRCA trans rs11098499 0.866 rs12499602 chr4:120284387 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs17376456 0.825 rs12188163 chr5:93250608 A/G cg21475434 chr5:93447410 FAM172A -0.64 -8.28 -0.31 7.29e-16 Diabetic retinopathy; BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg04944784 chr2:26401820 FAM59B -0.67 -11.17 -0.4 1.4e-26 Gut microbiome composition (summer); BRCA trans rs637571 0.522 rs649000 chr11:65742933 T/C cg17712092 chr4:129076599 LARP1B 0.56 13.46 0.47 1.62e-36 Eosinophil percentage of white cells; BRCA cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -18.88 -0.6 1.53e-63 Initial pursuit acceleration; BRCA cis rs7561273 0.609 rs10200844 chr2:24293363 A/C cg04809136 chr2:24300158 SF3B14 -0.4 -9.28 -0.34 2.62e-19 Quantitative traits; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg11814155 chr7:99998594 ZCWPW1 0.48 8.63 0.32 5.04e-17 Platelet count; BRCA cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg07636037 chr3:49044803 WDR6 0.41 8.39 0.32 3.03e-16 Resting heart rate; BRCA cis rs1443512 0.812 rs1975472 chr12:54337083 A/G cg17410650 chr12:54324560 NA -0.43 -10.83 -0.39 3.32e-25 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg15704280 chr7:45808275 SEPT13 0.52 8.96 0.33 3.48e-18 Axial length; BRCA cis rs9790314 1.000 rs1993891 chr3:161047467 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.04 -0.49 3.32e-39 Morning vs. evening chronotype; BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg17747265 chr1:1875780 NA 0.52 15.21 0.52 7.8e-45 Body mass index; BRCA cis rs1506636 0.720 rs633590 chr7:123442156 G/A cg03229431 chr7:123269106 ASB15 0.4 9.28 0.34 2.66e-19 Plateletcrit;Platelet count; BRCA cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg09035930 chr12:129282057 SLC15A4 0.56 16.41 0.54 9e-51 Systemic lupus erythematosus; BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg26314531 chr2:26401878 FAM59B 0.91 16.11 0.54 3.05e-49 Gut microbiome composition (summer); BRCA cis rs2243480 1.000 rs1723270 chr7:65469830 T/G cg18252515 chr7:66147081 NA -0.9 -12.91 -0.45 4.63e-34 Diabetic kidney disease; BRCA cis rs2463822 0.688 rs7121684 chr11:62162389 T/C cg06239285 chr11:62104954 ASRGL1 -0.67 -8.91 -0.33 5.21e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs57590327 0.555 rs13099615 chr3:81729101 T/A cg07356753 chr3:81810745 GBE1 -0.47 -11.26 -0.41 5.89e-27 Extraversion; BRCA cis rs7178424 1.000 rs8039651 chr15:62359350 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.43 -0.32 2.26e-16 Height; BRCA cis rs922182 0.579 rs4620909 chr15:64192739 C/T cg24729988 chr15:64271149 DAPK2 -0.43 -9.62 -0.36 1.49e-20 Blood protein levels; BRCA cis rs11252926 0.831 rs816570 chr10:680475 C/T cg08603382 chr10:743973 NA -0.43 -8.84 -0.33 9.34e-18 Psychosis in Alzheimer's disease; BRCA cis rs10751667 0.621 rs7396049 chr11:1001561 G/A ch.11.42038R chr11:967971 AP2A2 0.47 14.3 0.49 1.94e-40 Alzheimer's disease (late onset); BRCA cis rs6964587 0.610 rs6942852 chr7:91437883 A/C cg17063962 chr7:91808500 NA 0.48 10.83 0.39 3.24e-25 Breast cancer; BRCA cis rs2425143 1.000 rs11696527 chr20:34245379 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -8.97 -0.33 3.3e-18 Blood protein levels; BRCA cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg06698575 chr12:117470875 NA 0.44 8.23 0.31 1.09e-15 Subcortical brain region volumes;Hippocampal volume; BRCA trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg17470723 chr8:74884337 TCEB1 0.42 9.06 0.34 1.62e-18 Prostate cancer (SNP x SNP interaction); BRCA trans rs9929218 0.551 rs6499193 chr16:68727069 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.98 29.84 0.76 3.12e-123 Colorectal cancer; BRCA cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs250677 0.958 rs17109282 chr5:148416677 A/G cg23229984 chr5:148520753 ABLIM3 -0.32 -7.93 -0.3 9.61e-15 Breast cancer; BRCA cis rs3784262 1.000 rs7495968 chr15:58244103 C/G cg12031962 chr15:58353849 ALDH1A2 0.44 11.78 0.42 3.96e-29 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg12564285 chr5:131593104 PDLIM4 0.34 7.96 0.3 7.96e-15 Breast cancer; BRCA cis rs1538970 0.748 rs11211137 chr1:46013892 T/A cg05343316 chr1:45956843 TESK2 0.69 13.86 0.48 2.33e-38 Platelet count; BRCA cis rs7772486 0.686 rs1415744 chr6:146022531 C/T cg23711669 chr6:146136114 FBXO30 0.71 16.86 0.55 4.95e-53 Lobe attachment (rater-scored or self-reported); BRCA trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.12 -18.93 -0.6 8.81e-64 Hemostatic factors and hematological phenotypes; BRCA cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg03146154 chr1:46216737 IPP -0.44 -9.81 -0.36 2.94e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs453301 0.653 rs7016139 chr8:8895470 A/G cg21775007 chr8:11205619 TDH -0.39 -8.0 -0.3 5.89e-15 Joint mobility (Beighton score); BRCA trans rs2204008 0.582 rs11179135 chr12:38204689 A/C cg06521331 chr12:34319734 NA -0.54 -9.56 -0.35 2.48e-20 Bladder cancer; BRCA cis rs6430585 0.528 rs16832440 chr2:136754183 G/A cg07169764 chr2:136633963 MCM6 1.23 24.05 0.69 1.56e-91 Corneal structure; BRCA cis rs561341 1.000 rs510264 chr17:30323414 A/G cg12193833 chr17:30244370 NA -0.58 -8.89 -0.33 6.38e-18 Hip circumference adjusted for BMI; BRCA trans rs3780486 0.846 rs10971420 chr9:33125000 T/C cg04842962 chr6:43655489 MRPS18A 1.13 39.17 0.84 5.01e-172 IgG glycosylation; BRCA cis rs7677751 0.806 rs6836215 chr4:55102741 T/C cg17187183 chr4:55093834 PDGFRA 0.44 9.1 0.34 1.14e-18 Corneal astigmatism; BRCA cis rs4478137 0.931 rs7687423 chr4:164250797 C/T cg06758707 chr4:164254230 NPY1R -0.52 -11.49 -0.41 6.61e-28 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg08999081 chr20:33150536 PIGU 0.47 13.03 0.46 1.35e-34 Glomerular filtration rate (creatinine); BRCA cis rs17641971 0.662 rs13268440 chr8:50000873 C/T cg00325661 chr8:49890786 NA 0.36 10.07 0.37 3.09e-22 Blood metabolite levels; BRCA cis rs4478858 0.698 rs4949204 chr1:31800415 A/G cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg08999081 chr20:33150536 PIGU 0.47 12.92 0.46 4.18e-34 Glomerular filtration rate (creatinine); BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg15112475 chr7:1198522 ZFAND2A 0.51 11.5 0.41 5.92e-28 Longevity;Endometriosis; BRCA cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg24562669 chr7:97807699 LMTK2 -0.49 -13.2 -0.46 2.36e-35 Breast cancer; BRCA cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg02527881 chr3:46936655 PTH1R -0.36 -9.25 -0.34 3.45e-19 Colorectal cancer; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg00106254 chr7:1943704 MAD1L1 0.45 11.53 0.42 4.43e-28 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.22 0.37 8.18e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.747 rs4845509 chr1:152981900 T/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.28e-16 Inflammatory skin disease; BRCA cis rs12762955 0.608 rs7922760 chr10:1156815 G/C cg18964960 chr10:1102726 WDR37 -0.54 -9.33 -0.35 1.76e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg13010199 chr12:38710504 ALG10B 0.45 9.23 0.34 3.83e-19 Bladder cancer; BRCA cis rs3733585 0.577 rs28558552 chr4:9964913 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.21 -0.37 9.1e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17685 0.775 rs11761172 chr7:75761547 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.29 -0.38 4.4e-23 Alzheimer's disease (late onset); BRCA cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg13319975 chr6:146136371 FBXO30 -0.34 -7.86 -0.3 1.68e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1577917 1.000 rs10944161 chr6:86630376 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA cis rs4363385 0.782 rs394859 chr1:153025704 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.52 -0.32 1.18e-16 Inflammatory skin disease; BRCA cis rs9287719 0.934 rs4622695 chr2:10744327 C/T cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg15083037 chr5:83017644 HAPLN1 -0.51 -9.92 -0.37 1.11e-21 Prostate cancer; BRCA cis rs12541635 0.966 rs1603363 chr8:107031319 A/G cg10147462 chr8:107024639 NA 0.36 9.69 0.36 8.28e-21 Age of smoking initiation; BRCA cis rs701145 0.585 rs1713854 chr3:153848030 T/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs11191270 0.554 rs77616533 chr10:104055983 A/G cg15320455 chr10:103880129 LDB1 0.75 11.19 0.4 1.12e-26 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs12903149 chr15:45539076 G/A cg24006582 chr15:45444508 DUOX1 0.55 10.56 0.39 3.77e-24 Uric acid levels; BRCA trans rs61931739 0.500 rs11053212 chr12:34466116 T/G cg13010199 chr12:38710504 ALG10B 0.5 9.68 0.36 9.21e-21 Morning vs. evening chronotype; BRCA cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11644478 chr21:40555479 PSMG1 0.82 18.77 0.6 6.19e-63 Cognitive function; BRCA cis rs796364 0.906 rs281784 chr2:200749749 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.76 12.77 0.45 2.1e-33 Schizophrenia; BRCA cis rs12586317 0.547 rs10134907 chr14:35499211 A/C cg16230307 chr14:35515116 FAM177A1 0.73 15.06 0.51 4.55e-44 Psoriasis; BRCA cis rs17001868 0.568 rs760700 chr22:40800071 C/T cg07138101 chr22:40742427 ADSL -0.53 -10.13 -0.37 1.79e-22 Mammographic density (dense area); BRCA trans rs4650994 1.000 rs12138541 chr1:178518707 G/A cg05059571 chr16:84539110 KIAA1609 -0.43 -9.61 -0.36 1.6e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg02880119 chr16:3481970 NA 0.43 8.2 0.31 1.35e-15 Body mass index (adult); BRCA cis rs11098499 0.779 rs80242894 chr4:120375752 G/A cg09307838 chr4:120376055 NA 0.74 15.99 0.53 1.16e-48 Corneal astigmatism; BRCA cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg12386194 chr3:101231763 SENP7 0.66 12.97 0.46 2.58e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.679 rs6995378 chr8:58113933 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.98 -0.33 3.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg07308232 chr7:1071921 C7orf50 -0.4 -8.79 -0.33 1.37e-17 Longevity;Endometriosis; BRCA cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg12310025 chr6:25882481 NA -0.46 -10.36 -0.38 2.32e-23 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.869 rs2230655 chr6:26033506 A/G cg18357526 chr6:26021779 HIST1H4A -0.5 -9.14 -0.34 8.47e-19 Intelligence (multi-trait analysis); BRCA cis rs311392 0.902 rs413667 chr8:55091908 C/A cg11783602 chr8:55087084 NA -0.32 -9.11 -0.34 1.03e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs1865760 1.000 rs7739966 chr6:25906040 T/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.43 0.38 1.29e-23 Height; BRCA cis rs2050392 0.767 rs2183175 chr10:30699336 A/G cg18806716 chr10:30721971 MAP3K8 0.5 11.99 0.43 4.99e-30 Inflammatory bowel disease; BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg25036284 chr2:26402008 FAM59B -0.63 -10.61 -0.39 2.36e-24 Gut microbiome composition (summer); BRCA cis rs1865760 0.865 rs9467647 chr6:25957642 A/G cg16482183 chr6:26056742 HIST1H1C 0.51 10.58 0.39 3.17e-24 Height; BRCA cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg23711669 chr6:146136114 FBXO30 0.79 19.22 0.61 2.48e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs4880487 0.853 rs1876898 chr10:1249986 C/T cg03183215 chr10:1252341 ADARB2 -0.37 -8.42 -0.32 2.57e-16 Migraine; BRCA cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg24812749 chr6:127587940 RNF146 0.86 20.21 0.62 1.41e-70 Breast cancer; BRCA cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.46 0.38 9.36e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2742234 0.518 rs2505514 chr10:43633248 A/G cg15436174 chr10:43711423 RASGEF1A -0.55 -11.08 -0.4 3.33e-26 Hirschsprung disease; BRCA cis rs4423214 0.840 rs1790344 chr11:71176897 A/G cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs7799006 0.723 rs2270052 chr7:2291399 C/T cg08027265 chr7:2291960 NA -0.49 -12.83 -0.45 1.11e-33 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6987853 0.787 rs2974309 chr8:42426961 G/A cg09913449 chr8:42400586 C8orf40 0.42 9.29 0.34 2.43e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs1580019 0.563 rs13225132 chr7:32800975 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.07 29.9 0.76 1.47e-123 Cognitive ability; BRCA cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg12573674 chr2:1569213 NA -0.56 -12.07 -0.43 2.35e-30 IgG glycosylation; BRCA cis rs703842 0.616 rs871871 chr12:58219681 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.48 8.86 0.33 8.1e-18 Multiple sclerosis; BRCA cis rs68170813 0.559 rs79778437 chr7:107004972 T/A cg02696742 chr7:106810147 HBP1 -0.5 -8.41 -0.32 2.65e-16 Coronary artery disease; BRCA cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg26818010 chr10:134567672 INPP5A -0.71 -14.83 -0.51 5.95e-43 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7246967 0.673 rs34003335 chr19:22925602 T/C cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs10193935 0.901 rs9808509 chr2:42479644 T/C cg27598129 chr2:42591480 NA -0.99 -14.48 -0.5 2.77e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg05714579 chr10:131428358 MGMT -0.72 -18.25 -0.59 3.12e-60 Response to temozolomide; BRCA cis rs4319547 0.656 rs28730465 chr12:122863864 A/C cg05707623 chr12:122985044 ZCCHC8 0.49 9.42 0.35 7.79e-20 Body mass index; BRCA cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2282802 0.660 rs6873248 chr5:139683762 A/G cg26211634 chr5:139558579 C5orf32 -0.34 -8.17 -0.31 1.62e-15 Intelligence (multi-trait analysis); BRCA cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg11764359 chr7:65958608 NA 0.68 15.19 0.52 1.01e-44 Aortic root size; BRCA trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg26597838 chr10:835615 NA 0.85 15.53 0.52 2.34e-46 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg22974920 chr21:40686053 BRWD1 0.39 8.92 0.33 5.06e-18 Cognitive function; BRCA cis rs10197940 0.578 rs6718372 chr2:152345871 C/G cg19508488 chr2:152266495 RIF1 0.38 8.23 0.31 1.03e-15 Lung cancer; BRCA cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg12311346 chr5:56204834 C5orf35 0.58 12.15 0.43 1.07e-30 Initial pursuit acceleration; BRCA cis rs208520 0.690 rs2126120 chr6:66742754 A/G cg07460842 chr6:66804631 NA 0.99 19.85 0.62 1.08e-68 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg04944784 chr2:26401820 FAM59B -0.85 -13.31 -0.47 7.68e-36 Gut microbiome composition (summer); BRCA cis rs2617583 0.935 rs2975223 chr5:1443603 T/C cg07151155 chr5:1473589 LPCAT1 -0.38 -8.24 -0.31 1.01e-15 Breast cancer; BRCA cis rs6763687 0.725 rs9842575 chr3:171803152 G/A cg16233210 chr3:171778391 FNDC3B 0.35 7.99 0.3 6.15e-15 Red cell distribution width; BRCA cis rs2712184 1.000 rs2712184 chr2:217682779 G/T cg05032264 chr2:217675019 NA -0.46 -11.42 -0.41 1.24e-27 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs17384381 1.000 rs12135333 chr1:85890494 C/A cg16011679 chr1:85725395 C1orf52 0.54 8.33 0.31 4.9e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9420 0.961 rs17455520 chr11:57540458 C/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.55 -0.44 1.96e-32 Schizophrenia; BRCA cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg03684893 chr10:554711 DIP2C -0.4 -9.52 -0.35 3.46e-20 Psychosis in Alzheimer's disease; BRCA cis rs9287719 0.967 rs4668691 chr2:10740494 C/T cg00105475 chr2:10696890 NA 0.44 10.37 0.38 2.16e-23 Prostate cancer; BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg16606324 chr3:10149918 C3orf24 0.57 11.37 0.41 2.08e-27 Alzheimer's disease; BRCA cis rs8062405 0.755 rs17640009 chr16:28595700 A/G cg16576597 chr16:28551801 NUPR1 0.32 8.92 0.33 4.94e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg08888203 chr3:10149979 C3orf24 0.62 12.78 0.45 1.79e-33 Alzheimer's disease; BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg14863265 chr7:2801509 GNA12 -0.45 -9.73 -0.36 5.68e-21 Height; BRCA cis rs9647379 1.000 rs9647379 chr3:171785168 C/G cg16233210 chr3:171778391 FNDC3B 0.38 8.5 0.32 1.37e-16 Heart rate; BRCA cis rs600806 0.713 rs10745305 chr1:110012148 A/G cg20591472 chr1:110008990 SYPL2 0.31 7.85 0.3 1.77e-14 Intelligence (multi-trait analysis); BRCA cis rs897080 0.515 rs1067402 chr2:44676226 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.52 -9.2 -0.34 4.94e-19 Height; BRCA cis rs2108225 1.000 rs2108225 chr7:107453103 G/A cg18560240 chr7:107437656 SLC26A3 -0.51 -10.24 -0.38 7.07e-23 Ulcerative colitis; BRCA cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg24642439 chr20:33292090 TP53INP2 0.51 11.25 0.41 6.53e-27 Glomerular filtration rate (creatinine); BRCA cis rs6089829 0.926 rs1060489 chr20:61665921 C/T cg08045932 chr20:61659980 NA 0.48 10.9 0.4 1.68e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg24838063 chr12:130822603 PIWIL1 0.68 16.73 0.55 2.13e-52 Menopause (age at onset); BRCA cis rs36051895 0.659 rs12343867 chr9:5074189 T/C cg02405213 chr9:5042618 JAK2 -0.52 -9.56 -0.35 2.58e-20 Pediatric autoimmune diseases; BRCA cis rs2070488 0.965 rs2051216 chr3:38562288 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.7 -19.36 -0.61 4.69e-66 Electrocardiographic conduction measures; BRCA cis rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05901451 chr6:126070800 HEY2 0.4 9.63 0.36 1.39e-20 Endometrial cancer; BRCA trans rs6479891 1.000 rs4466712 chr10:64933268 G/C cg14819942 chr15:35414228 NA 0.35 8.42 0.32 2.46e-16 Arthritis (juvenile idiopathic); BRCA cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg00684032 chr4:1343700 KIAA1530 0.52 11.98 0.43 5.37e-30 Obesity-related traits; BRCA cis rs6772849 0.930 rs9813197 chr3:128369104 G/A cg16766828 chr3:128327626 NA -0.39 -8.59 -0.32 6.9e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs68170813 0.559 rs11761181 chr7:106954879 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.53 -0.32 1.02e-16 Coronary artery disease; BRCA trans rs2739330 0.828 rs5760108 chr22:24252668 G/T cg06437703 chr8:37914619 EIF4EBP1 -0.31 -8.28 -0.31 7.36e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7577696 0.597 rs11691939 chr2:32339561 A/G cg02381751 chr2:32503542 YIPF4 0.42 8.07 0.3 3.59e-15 Inflammatory biomarkers; BRCA cis rs16858210 0.607 rs60244260 chr3:183570734 G/A cg25686905 chr3:183603175 PARL -0.39 -8.43 -0.32 2.35e-16 Menopause (age at onset); BRCA trans rs10506458 1.000 rs17763435 chr12:63416511 A/G cg22491629 chr6:157744540 C6orf35 0.6 10.84 0.39 3.09e-25 Hemostatic factors and hematological phenotypes; BRCA cis rs1577917 0.771 rs9362239 chr6:86429263 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 13.43 0.47 2.02e-36 Response to antipsychotic treatment; BRCA cis rs1008375 0.966 rs2159582 chr4:17695655 T/C cg16339924 chr4:17578868 LAP3 0.57 13.8 0.48 4.26e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs921968 0.565 rs7599568 chr2:219607819 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 5.98e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs10503871 1.000 rs10503872 chr8:30437031 C/G cg26383811 chr8:30366931 RBPMS -0.31 -8.49 -0.32 1.45e-16 Metabolite levels (X-11787); BRCA cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.48 -0.5 2.63e-41 Hemoglobin concentration; BRCA cis rs3806843 0.900 rs2563280 chr5:140131530 G/C cg11822812 chr5:140052017 DND1 -0.32 -8.72 -0.33 2.3e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg02153584 chr22:29168773 CCDC117 -0.54 -11.43 -0.41 1.19e-27 Lymphocyte counts; BRCA cis rs796364 1.000 rs281794 chr2:200846666 C/T cg23649088 chr2:200775458 C2orf69 0.56 8.22 0.31 1.1e-15 Schizophrenia; BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg02951883 chr7:2050386 MAD1L1 -0.61 -15.77 -0.53 1.47e-47 Autism spectrum disorder or schizophrenia; BRCA cis rs733175 0.855 rs9291640 chr4:10007086 C/T cg00071950 chr4:10020882 SLC2A9 0.42 8.79 0.33 1.41e-17 Psychosis and Alzheimer's disease; BRCA cis rs6840360 0.571 rs875668 chr4:152525661 C/T cg22705602 chr4:152727874 NA -0.33 -8.22 -0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg07606381 chr6:8435919 SLC35B3 0.64 14.09 0.49 1.94e-39 Motion sickness; BRCA cis rs1707322 1.000 rs4660318 chr1:46334876 A/G cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.76e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs965469 0.779 rs1884563 chr20:3335540 T/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.77 -0.33 1.66e-17 IFN-related cytopenia; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg04944784 chr2:26401820 FAM59B 0.99 16.56 0.55 1.61e-51 Gut microbiome composition (summer); BRCA cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg12292205 chr6:26970375 C6orf41 -0.8 -19.63 -0.61 1.68e-67 Autism spectrum disorder or schizophrenia; BRCA cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg08601574 chr20:25228251 PYGB -0.34 -8.19 -0.31 1.4e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs738322 0.742 rs4821767 chr22:38614129 G/T cg25457927 chr22:38595422 NA 0.36 13.48 0.47 1.2e-36 Cutaneous nevi; BRCA cis rs1577917 0.917 rs13213603 chr6:86534758 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs919433 0.963 rs4850428 chr2:198169772 G/A cg10820045 chr2:198174542 NA -0.38 -7.82 -0.3 2.17e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg04450456 chr4:17643702 FAM184B 0.36 10.4 0.38 1.59e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9807989 0.507 rs6726985 chr2:103048580 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma; BRCA cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg10523679 chr1:76189770 ACADM 0.67 11.15 0.4 1.73e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9837602 1.000 rs62285461 chr3:99767642 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.29e-26 Breast cancer; BRCA cis rs9462027 0.651 rs9469884 chr6:34758703 A/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.2e-15 Systemic lupus erythematosus; BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg04944784 chr2:26401820 FAM59B -0.67 -11.11 -0.4 2.43e-26 Gut microbiome composition (summer); BRCA cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg11764359 chr7:65958608 NA -0.77 -17.73 -0.57 1.71e-57 Aortic root size; BRCA cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg02018176 chr4:1364513 KIAA1530 0.41 8.24 0.31 1.01e-15 Longevity; BRCA trans rs3857536 0.813 rs9453639 chr6:66933538 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.17 -0.31 1.66e-15 Blood trace element (Cu levels); BRCA trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg15934090 chr1:100435551 SLC35A3 0.37 8.48 0.32 1.57e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg24308560 chr3:49941425 MST1R 0.39 8.33 0.31 4.92e-16 Intelligence (multi-trait analysis); BRCA cis rs939658 0.805 rs11638625 chr15:79434787 T/G cg17916960 chr15:79447300 NA -0.44 -10.74 -0.39 7.83e-25 Refractive error; BRCA cis rs11893307 0.599 rs13423600 chr2:191668301 C/T cg05765582 chr2:191677683 NA 0.44 7.98 0.3 6.64e-15 Mean platelet volume; BRCA cis rs367943 0.966 rs455435 chr5:112799412 T/C cg12552261 chr5:112820674 MCC -0.55 -12.22 -0.44 4.98e-31 Type 2 diabetes; BRCA cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg23029597 chr12:123009494 RSRC2 -0.59 -11.94 -0.43 8.67e-30 Body mass index; BRCA cis rs9790314 0.521 rs13084731 chr3:161086020 G/A cg04691961 chr3:161091175 C3orf57 -0.46 -10.85 -0.39 2.66e-25 Morning vs. evening chronotype; BRCA cis rs8062405 1.000 rs7187776 chr16:28857645 A/G cg09754948 chr16:28834200 ATXN2L 0.38 7.82 0.3 2.13e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg18225595 chr11:63971243 STIP1 -0.52 -9.17 -0.34 6.58e-19 Mean platelet volume; BRCA cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.96 0.4 9.71e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.26 0.41 5.76e-27 Height; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg26314531 chr2:26401878 FAM59B 0.95 16.32 0.54 2.75e-50 Gut microbiome composition (summer); BRCA cis rs4805272 0.512 rs17772319 chr19:29343064 T/A cg04546413 chr19:29218101 NA 0.49 8.34 0.31 4.55e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA trans rs2018683 0.834 rs2012754 chr7:29026257 G/A cg19402173 chr7:128379420 CALU -0.54 -12.97 -0.46 2.45e-34 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg21395723 chr22:39101663 GTPBP1 0.38 8.32 0.31 5.17e-16 Menopause (age at onset); BRCA cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg11833968 chr6:79620685 NA -0.42 -9.55 -0.35 2.81e-20 Intelligence (multi-trait analysis); BRCA cis rs757110 0.770 rs4439492 chr11:17386733 C/T cg15432903 chr11:17409602 KCNJ11 0.72 15.86 0.53 5.11e-48 Type 2 diabetes; BRCA cis rs6580649 0.941 rs1859441 chr12:48423233 C/T cg24011408 chr12:48396354 COL2A1 -0.49 -7.98 -0.3 6.99e-15 Lung cancer; BRCA cis rs7727544 0.716 rs11949055 chr5:131576737 T/C cg14196790 chr5:131705035 SLC22A5 0.45 11.58 0.42 2.81e-28 Blood metabolite levels; BRCA cis rs7618501 0.699 rs2681781 chr3:49898273 A/G cg05623727 chr3:50126028 RBM5 0.42 9.94 0.37 9.6e-22 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.33 0.49 1.32e-40 Motion sickness; BRCA cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.25e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs919433 0.854 rs13013049 chr2:198208664 C/T cg00792783 chr2:198669748 PLCL1 -0.39 -8.22 -0.31 1.1e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9811920 0.893 rs720688 chr3:99880569 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 11.59 0.42 2.57e-28 Axial length; BRCA cis rs4727027 0.834 rs7811446 chr7:148773226 G/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.25 0.31 9.17e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1994135 0.549 rs2218650 chr12:33734783 A/G cg06521331 chr12:34319734 NA -0.44 -8.56 -0.32 8.17e-17 Resting heart rate; BRCA cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.48 0.32 1.51e-16 Diabetic retinopathy; BRCA cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 9.14 0.34 8.49e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs7827545 1.000 rs4909910 chr8:135565201 T/C cg17885191 chr8:135476712 NA 0.47 9.19 0.34 5.3e-19 Hypertension (SNP x SNP interaction); BRCA trans rs2018683 0.683 rs12538606 chr7:28969408 T/C cg19402173 chr7:128379420 CALU -0.42 -10.06 -0.37 3.47e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs2835872 0.584 rs1709816 chr21:39077259 A/C cg06728970 chr21:39037746 KCNJ6 0.32 8.32 0.31 5.24e-16 Electroencephalographic traits in alcoholism; BRCA cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg26408565 chr15:76604113 ETFA -0.47 -10.06 -0.37 3.23e-22 Blood metabolite levels; BRCA cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg25427524 chr10:38739819 LOC399744 -0.68 -16.41 -0.54 9.23e-51 Extrinsic epigenetic age acceleration; BRCA cis rs6987853 0.787 rs2974300 chr8:42440532 C/T cg09913449 chr8:42400586 C8orf40 0.37 7.84 0.3 1.83e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs1832871 0.672 rs7745596 chr6:158732991 T/A cg07165851 chr6:158734300 TULP4 0.63 12.66 0.45 6.25e-33 Height; BRCA cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.21 0.46 2.22e-35 Bipolar disorder; BRCA trans rs561341 1.000 rs72823789 chr17:30284084 G/A cg20587970 chr11:113659929 NA -1.34 -24.49 -0.7 6.49e-94 Hip circumference adjusted for BMI; BRCA cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.1 -0.34 1.14e-18 Bipolar disorder; BRCA cis rs4970988 0.556 rs6681426 chr1:150586971 G/A cg18016565 chr1:150552671 MCL1 -0.41 -9.39 -0.35 1.08e-19 Urate levels; BRCA cis rs367615 0.840 rs113540823 chr5:108879084 C/T cg17395555 chr5:108820864 NA 0.37 9.39 0.35 1.03e-19 Colorectal cancer (SNP x SNP interaction); BRCA cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg13319975 chr6:146136371 FBXO30 0.39 8.84 0.33 9.25e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4076764 0.914 rs7536270 chr1:163377379 T/C cg06092702 chr1:163392909 NA -0.35 -9.39 -0.35 1.02e-19 Motion sickness; BRCA cis rs7737355 0.947 rs9327619 chr5:130921781 A/G cg06307176 chr5:131281290 NA 0.52 10.37 0.38 2.19e-23 Life satisfaction; BRCA cis rs926392 0.692 rs6028259 chr20:37696977 T/A cg16355469 chr20:37678765 NA 0.49 11.75 0.42 5.51e-29 Dialysis-related mortality; BRCA cis rs9644630 1.000 rs9644630 chr8:19370598 C/T cg01280390 chr8:19363452 CSGALNACT1 0.38 8.37 0.31 3.6e-16 Oropharynx cancer; BRCA cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg22467129 chr15:76604101 ETFA -0.39 -8.62 -0.32 5.14e-17 Blood metabolite levels; BRCA cis rs11690935 0.959 rs6745143 chr2:172650382 G/A cg13550731 chr2:172543902 DYNC1I2 -0.91 -30.23 -0.77 2.47e-125 Schizophrenia; BRCA cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.81 0.33 1.14e-17 Motion sickness; BRCA cis rs6545883 0.868 rs6752938 chr2:61841588 C/T cg15711740 chr2:61764176 XPO1 -0.49 -12.19 -0.43 7.25e-31 Tuberculosis; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 9.44 0.35 6.81e-20 Longevity;Endometriosis; BRCA cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg09184832 chr6:79620586 NA -0.52 -11.41 -0.41 1.44e-27 Intelligence (multi-trait analysis); BRCA cis rs10493773 0.928 rs12741600 chr1:86191172 A/C cg17807903 chr1:86174739 ZNHIT6 -0.47 -10.51 -0.38 6.05e-24 Urate levels in overweight individuals; BRCA cis rs2742234 0.541 rs2742235 chr10:43616325 A/G cg15436174 chr10:43711423 RASGEF1A -0.53 -10.69 -0.39 1.18e-24 Hirschsprung disease; BRCA trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg08313168 chr12:7315531 NA 0.5 8.06 0.3 3.68e-15 Lung disease severity in cystic fibrosis; BRCA trans rs3733585 0.699 rs62294331 chr4:9959889 A/G cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg21782813 chr7:2030301 MAD1L1 0.4 11.59 0.42 2.45e-28 Bipolar disorder and schizophrenia; BRCA cis rs12472274 0.941 rs2880131 chr2:239089151 A/C cg17459225 chr2:239074497 NA 0.63 13.38 0.47 3.69e-36 Phospholipid levels (plasma); BRCA cis rs4478858 0.735 rs6676354 chr1:31800746 A/T cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs1215050 0.740 rs11097580 chr4:98767255 C/A cg05340658 chr4:99064831 C4orf37 0.45 10.24 0.38 7.17e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10267417 0.603 rs10263119 chr7:19872844 C/G cg07541023 chr7:19748670 TWISTNB 0.47 8.45 0.32 2e-16 Night sleep phenotypes; BRCA cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg16325326 chr1:53192061 ZYG11B 0.65 16.11 0.54 2.83e-49 Monocyte count; BRCA cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg16325326 chr1:53192061 ZYG11B -0.71 -18.64 -0.59 3.1e-62 Monocyte count; BRCA cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg16179182 chr5:140090404 VTRNA1-1 0.41 9.51 0.35 3.88e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs10782582 0.593 rs114421765 chr1:76141802 C/T cg03433033 chr1:76189801 ACADM -0.45 -8.69 -0.33 2.92e-17 Daytime sleep phenotypes; BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg27170947 chr2:26402098 FAM59B -0.8 -12.95 -0.46 3.1e-34 Gut microbiome composition (summer); BRCA cis rs1043763 0.826 rs2017594 chr12:122631208 A/C cg14400030 chr12:122498111 BCL7A -0.46 -10.47 -0.38 8.41e-24 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs992157 0.798 rs10206064 chr2:219157959 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.53 11.41 0.41 1.4e-27 Colorectal cancer; BRCA trans rs6479891 1.000 rs7081275 chr10:65106551 G/T cg14819942 chr15:35414228 NA -0.34 -8.27 -0.31 7.77e-16 Arthritis (juvenile idiopathic); BRCA cis rs4243830 0.649 rs11579888 chr1:6609896 G/A cg22792644 chr1:6614718 TAS1R1;NOL9 -0.89 -17.62 -0.57 6.1e-57 Body mass index; BRCA cis rs2836974 0.681 rs8128827 chr21:40710547 C/T cg17971929 chr21:40555470 PSMG1 0.73 16.34 0.54 1.99e-50 Cognitive function; BRCA cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg15017067 chr4:17643749 FAM184B 0.3 9.3 0.35 2.18e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12142240 0.698 rs17357621 chr1:46807697 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.02 0.3 5.11e-15 Menopause (age at onset); BRCA cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.62 -15.45 -0.52 5.35e-46 Colorectal cancer; BRCA cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24531977 chr5:56204891 C5orf35 -0.87 -18.04 -0.58 4.2e-59 Initial pursuit acceleration; BRCA cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg13628971 chr7:2884303 GNA12 0.4 9.02 0.34 2.22e-18 Height; BRCA cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg06453172 chr10:134556979 INPP5A -0.6 -11.77 -0.42 4.54e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7584330 0.554 rs6740722 chr2:238393288 T/C cg14458575 chr2:238380390 NA 0.53 8.63 0.32 4.85e-17 Prostate cancer; BRCA cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg00071950 chr4:10020882 SLC2A9 0.54 13.35 0.47 4.83e-36 Bone mineral density; BRCA cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg12011299 chr4:100065546 ADH4 -0.51 -11.79 -0.42 3.6e-29 Alcohol dependence; BRCA cis rs6743226 1.000 rs6743226 chr2:242236972 T/C cg10021735 chr2:242295487 FARP2 0.36 9.99 0.37 6.3e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs34779708 0.931 rs2384275 chr10:35297142 A/G cg03585969 chr10:35415529 CREM 0.45 9.38 0.35 1.11e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg24675658 chr1:53192096 ZYG11B 0.55 12.64 0.45 7.42e-33 Monocyte count; BRCA cis rs10911363 0.592 rs12117885 chr1:183494214 C/T cg09173681 chr1:183549694 NCF2 -0.52 -11.11 -0.4 2.4e-26 Systemic lupus erythematosus; BRCA cis rs796364 1.000 rs166845 chr2:200823360 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.72 12.01 0.43 4.39e-30 Schizophrenia; BRCA cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg18876405 chr7:65276391 NA 0.71 18.71 0.59 1.35e-62 Calcium levels; BRCA trans rs4718428 1.000 rs1830070 chr7:66349671 T/C cg18876405 chr7:65276391 NA 0.46 10.03 0.37 4.49e-22 Corneal structure; BRCA cis rs4481887 0.927 rs4558008 chr1:248477641 C/T cg00666640 chr1:248458726 OR2T12 0.29 8.29 0.31 6.65e-16 Common traits (Other); BRCA cis rs4363385 0.747 rs7521181 chr1:152955223 G/A cg21543102 chr1:152974771 SPRR3 -0.3 -8.63 -0.32 4.99e-17 Inflammatory skin disease; BRCA cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg05283184 chr6:79620031 NA -0.36 -8.22 -0.31 1.17e-15 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.683 rs6449140 chr4:9936437 G/C cg26043149 chr18:55253948 FECH -0.42 -9.35 -0.35 1.47e-19 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7917772 0.503 rs11191320 chr10:104293394 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs72928364 0.929 rs13059867 chr3:100765548 T/C cg10123952 chr3:100791384 NA 0.59 8.67 0.32 3.55e-17 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 0.525 rs997516 chr19:37474264 T/C cg18154014 chr19:37997991 ZNF793 0.49 8.39 0.32 3.11e-16 Coronary artery calcification; BRCA cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.9 -0.33 5.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg22601191 chr20:60968625 CABLES2 0.36 8.92 0.33 4.74e-18 Colorectal cancer; BRCA cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg22467129 chr15:76604101 ETFA -0.48 -10.44 -0.38 1.19e-23 Blood metabolite levels; BRCA cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.92 0.4 1.41e-25 Intelligence (multi-trait analysis); BRCA cis rs11677370 0.561 rs13015012 chr2:3821252 C/G cg17052675 chr2:3827356 NA 0.59 15.03 0.51 6.31e-44 Type 2 diabetes; BRCA cis rs9868809 0.505 rs11708786 chr3:48752654 C/T cg00383909 chr3:49044727 WDR6 0.57 10.92 0.4 1.41e-25 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs11190604 0.767 rs11190509 chr10:102156208 G/A cg07080220 chr10:102295463 HIF1AN 0.51 10.51 0.38 6.08e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs701145 0.537 rs1358403 chr3:153862757 C/T cg17054900 chr3:154042577 DHX36 0.55 9.23 0.34 3.79e-19 Coronary artery disease; BRCA cis rs9818758 0.607 rs34566463 chr3:49245077 T/C cg00383909 chr3:49044727 WDR6 0.7 12.27 0.44 3.2e-31 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs79976124 0.842 rs1548154 chr6:66624910 G/A cg07460842 chr6:66804631 NA 0.63 11.23 0.41 8.2e-27 Type 2 diabetes; BRCA cis rs8180040 0.593 rs4018905 chr3:47138170 A/G cg27129171 chr3:47204927 SETD2 0.73 17.78 0.58 8.77e-58 Colorectal cancer; BRCA cis rs875971 0.862 rs1167399 chr7:65561877 G/A cg11764359 chr7:65958608 NA -0.74 -16.09 -0.54 3.77e-49 Aortic root size; BRCA cis rs1153858 1.000 rs56850226 chr15:45633118 T/C cg21132104 chr15:45694354 SPATA5L1 0.75 16.79 0.55 1.18e-52 Homoarginine levels; BRCA cis rs6062509 0.839 rs6062298 chr20:62301970 G/A cg03425785 chr20:62221387 GMEB2 -0.44 -8.31 -0.31 5.78e-16 Prostate cancer; BRCA cis rs6456156 0.586 rs10946209 chr6:167480991 G/A cg07741184 chr6:167504864 NA 0.34 10.05 0.37 3.65e-22 Primary biliary cholangitis; BRCA cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11890956 chr21:40555474 PSMG1 -0.59 -13.27 -0.46 1.09e-35 Menarche (age at onset); BRCA cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg24549020 chr5:56110836 MAP3K1 0.41 8.58 0.32 7.34e-17 Initial pursuit acceleration; BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg13047869 chr3:10149882 C3orf24 0.6 12.76 0.45 2.33e-33 Alzheimer's disease; BRCA cis rs895636 0.756 rs10192373 chr2:45191962 G/A cg16198908 chr2:45192207 NA 0.49 9.32 0.35 1.81e-19 Metabolite levels;Fasting plasma glucose; BRCA cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.96e-15 Depression; BRCA cis rs4319547 0.656 rs7135419 chr12:122911861 T/A cg23029597 chr12:123009494 RSRC2 -0.6 -11.65 -0.42 1.35e-28 Body mass index; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg27170947 chr2:26402098 FAM59B 0.97 16.89 0.56 3.52e-53 Gut microbiome composition (summer); BRCA cis rs6570726 0.935 rs369458 chr6:145812809 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.03 0.51 6.14e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs853679 0.517 rs1947863 chr6:28099344 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.39e-15 Depression; BRCA cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg05294307 chr14:35346193 BAZ1A -0.62 -10.54 -0.38 4.7e-24 Psoriasis; BRCA cis rs3767633 0.528 rs4417044 chr1:161888955 T/C cg27519958 chr1:161735129 ATF6 -0.49 -11.73 -0.42 6.39e-29 IgG glycosylation; BRCA cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg06115741 chr20:33292138 TP53INP2 0.5 10.82 0.39 3.72e-25 Coronary artery disease; BRCA cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg10523679 chr1:76189770 ACADM 0.47 9.15 0.34 7.37e-19 Daytime sleep phenotypes; BRCA cis rs35306767 0.903 rs765867 chr10:869901 G/T cg26597838 chr10:835615 NA 1.01 17.83 0.58 5.39e-58 Eosinophil percentage of granulocytes; BRCA cis rs13266463 0.830 rs7014552 chr8:143410423 A/G cg16886403 chr8:143471632 TSNARE1 0.45 9.54 0.35 2.95e-20 Schizophrenia; BRCA cis rs17209837 0.607 rs4148821 chr7:87079602 G/C cg00919237 chr7:87102261 ABCB4 -0.5 -8.99 -0.33 2.84e-18 Gallbladder cancer; BRCA cis rs752010 0.668 rs10890147 chr1:42089725 A/T cg06885757 chr1:42089581 HIVEP3 0.41 13.57 0.47 4.76e-37 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2859741 0.967 rs522481 chr1:37488337 C/T cg09363841 chr1:37513479 NA -0.65 -16.71 -0.55 2.76e-52 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg18402987 chr7:1209562 NA 0.66 11.33 0.41 3.06e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10870270 1.000 rs11146324 chr10:133767445 A/C cg08754478 chr10:133766260 PPP2R2D -0.69 -14.13 -0.49 1.22e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg04267008 chr7:1944627 MAD1L1 0.57 12.63 0.45 8.04e-33 Bipolar disorder and schizophrenia; BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.04 -0.3 4.3e-15 Bipolar disorder and schizophrenia; BRCA cis rs16858210 0.874 rs10937153 chr3:183562925 A/G cg25686905 chr3:183603175 PARL 0.37 9.04 0.34 1.83e-18 Menopause (age at onset); BRCA cis rs9560113 1.000 rs9560109 chr13:112180468 C/T cg10483660 chr13:112241077 NA 0.31 7.88 0.3 1.45e-14 Menarche (age at onset); BRCA cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg02018176 chr4:1364513 KIAA1530 0.37 8.01 0.3 5.41e-15 Longevity; BRCA cis rs763121 1.000 rs763121 chr22:38879940 C/T cg06022373 chr22:39101656 GTPBP1 -0.5 -11.15 -0.4 1.6e-26 Menopause (age at onset); BRCA cis rs7586879 0.593 rs11689546 chr2:25130451 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.31e-28 Body mass index; BRCA cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg08000102 chr2:233561755 GIGYF2 0.64 13.93 0.48 1.06e-38 Coronary artery disease; BRCA cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg26384229 chr12:38710491 ALG10B 0.69 16.07 0.54 4.72e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg04025307 chr7:1156635 C7orf50 0.57 13.38 0.47 3.7e-36 Longevity;Endometriosis; BRCA cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.42 -0.35 8.15e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg03808351 chr9:123631620 PHF19 0.39 7.83 0.3 1.99e-14 Rheumatoid arthritis; BRCA cis rs7264396 0.697 rs6142416 chr20:34174092 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.42 8.86 0.33 7.88e-18 Total cholesterol levels; BRCA cis rs992157 1.000 rs4674280 chr2:219141458 C/G cg20019365 chr2:219134978 PNKD;AAMP -0.56 -12.67 -0.45 5.74e-33 Colorectal cancer; BRCA cis rs7809950 0.906 rs62483723 chr7:107186358 A/C cg23024343 chr7:107201750 COG5 -0.39 -8.96 -0.33 3.55e-18 Coronary artery disease; BRCA trans rs3733585 0.699 rs6449178 chr4:9968684 A/G cg26043149 chr18:55253948 FECH 0.37 8.23 0.31 1.08e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs8114671 0.562 rs6088622 chr20:33419977 C/A cg07148914 chr20:33460835 GGT7 0.36 7.99 0.3 6.34e-15 Height; BRCA cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg08885076 chr2:99613938 TSGA10 -0.52 -11.8 -0.42 3.27e-29 Chronic sinus infection; BRCA trans rs9325144 0.647 rs12231313 chr12:39101929 C/T cg23762105 chr12:34175262 ALG10 0.35 7.86 0.3 1.66e-14 Morning vs. evening chronotype; BRCA cis rs6866344 0.697 rs58549512 chr5:178133204 C/T cg10224037 chr5:178157518 ZNF354A 0.76 16.12 0.54 2.66e-49 Neutrophil percentage of white cells; BRCA cis rs6570726 0.935 rs380433 chr6:145859601 A/T cg23711669 chr6:146136114 FBXO30 0.63 14.8 0.51 7.87e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg05025164 chr4:1340916 KIAA1530 0.77 15.67 0.53 4.35e-47 Longevity; BRCA cis rs2712184 0.756 rs2712163 chr2:217660346 G/A cg05032264 chr2:217675019 NA -0.38 -9.14 -0.34 8.4e-19 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs6547741 1.000 rs6749052 chr2:27772879 A/T cg27432699 chr2:27873401 GPN1 0.47 9.9 0.36 1.34e-21 Oral cavity cancer; BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg27170947 chr2:26402098 FAM59B -0.9 -17.26 -0.56 4.45e-55 Gut microbiome composition (summer); BRCA cis rs1371614 0.635 rs9309559 chr2:27141515 G/T cg00617064 chr2:27272375 NA -0.3 -7.94 -0.3 9.11e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg24006582 chr15:45444508 DUOX1 0.56 11.23 0.41 8.18e-27 Uric acid levels; BRCA cis rs11190604 1.000 rs11190557 chr10:102209369 G/A cg07080220 chr10:102295463 HIF1AN 0.49 11.33 0.41 2.98e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg00321850 chr1:175162397 KIAA0040 -0.41 -11.47 -0.41 8.16e-28 Alcohol dependence; BRCA cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.62 -0.61 1.95e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17253792 0.822 rs77420254 chr14:56069646 C/T cg01858014 chr14:56050164 KTN1 -0.74 -9.35 -0.35 1.43e-19 Putamen volume; BRCA cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg03560586 chr2:239334908 ASB1 -0.41 -7.87 -0.3 1.55e-14 Multiple system atrophy; BRCA cis rs758324 0.947 rs683749 chr5:131283376 C/T cg06307176 chr5:131281290 NA -0.54 -10.46 -0.38 9.42e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg00071950 chr4:10020882 SLC2A9 0.57 14.04 0.49 3.22e-39 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg14863265 chr7:2801509 GNA12 -0.46 -9.76 -0.36 4.45e-21 Height; BRCA cis rs3768617 0.510 rs2027076 chr1:183073407 C/A ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.43e-58 Fuchs's corneal dystrophy; BRCA cis rs1215050 0.740 rs1214997 chr4:99041533 A/T cg05340658 chr4:99064831 C4orf37 0.5 11.62 0.42 1.81e-28 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs61931739 0.500 rs6488218 chr12:34452587 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.62 0.36 1.45e-20 Morning vs. evening chronotype; BRCA cis rs7918232 0.662 rs10741125 chr10:27288925 G/A cg14442939 chr10:27389572 ANKRD26 0.52 8.96 0.33 3.52e-18 Breast cancer; BRCA cis rs7264396 0.790 rs6060582 chr20:34313297 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.75 16.18 0.54 1.29e-49 Total cholesterol levels; BRCA cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.21 -0.34 4.7e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs10751667 0.666 rs7396509 chr11:956761 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.66 0.55 5.33e-52 Alzheimer's disease (late onset); BRCA trans rs8073060 0.586 rs225286 chr17:33930458 G/A cg19694781 chr19:47549865 TMEM160 -1.06 -21.28 -0.64 2.4e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg08888203 chr3:10149979 C3orf24 0.67 14.07 0.49 2.26e-39 Alzheimer's disease; BRCA cis rs7131987 0.650 rs4331146 chr12:29440083 G/T cg09582351 chr12:29534625 ERGIC2 -0.46 -10.62 -0.39 2.23e-24 QT interval; BRCA cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg13628971 chr7:2884303 GNA12 0.42 9.66 0.36 1.06e-20 Height; BRCA cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg26116260 chr4:7069785 GRPEL1 0.82 17.47 0.57 3.85e-56 Monocyte percentage of white cells; BRCA cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg11764359 chr7:65958608 NA 0.8 19.2 0.6 3.43e-65 Aortic root size; BRCA cis rs4363385 0.720 rs1415967 chr1:152965585 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.37 -0.35 1.23e-19 Inflammatory skin disease; BRCA cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg06212747 chr3:49208901 KLHDC8B -0.53 -11.47 -0.41 7.68e-28 Menarche (age at onset); BRCA cis rs7552404 0.961 rs448710 chr1:76116554 T/C cg03433033 chr1:76189801 ACADM -0.77 -17.67 -0.57 3.38e-57 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg24531977 chr5:56204891 C5orf35 0.72 15.75 0.53 1.83e-47 Initial pursuit acceleration; BRCA cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 8.02e-41 Motion sickness; BRCA cis rs758324 0.741 rs10075660 chr5:131240843 C/A cg06307176 chr5:131281290 NA -0.49 -9.56 -0.35 2.52e-20 Alzheimer's disease in APOE e4- carriers; BRCA cis rs877282 0.898 rs36064821 chr10:760952 C/T cg17470449 chr10:769945 NA 0.47 8.0 0.3 5.93e-15 Uric acid levels; BRCA cis rs4800452 0.549 rs9947743 chr18:20708321 G/A cg26136497 chr18:20735537 CABLES1 -0.41 -9.35 -0.35 1.48e-19 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg12386194 chr3:101231763 SENP7 0.47 9.87 0.36 1.82e-21 Colorectal cancer; BRCA cis rs478304 0.651 rs10896038 chr11:65505528 G/C cg10518572 chr11:65560635 OVOL1 -0.3 -8.34 -0.31 4.5e-16 Acne (severe); BRCA cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.61 -13.68 -0.48 1.51e-37 Platelet count; BRCA cis rs782590 0.805 rs782578 chr2:55915904 A/C cg18811423 chr2:55921094 PNPT1 0.77 26.48 0.72 7.31e-105 Metabolic syndrome; BRCA cis rs7512552 0.803 rs2454286 chr1:150355538 G/A cg15654264 chr1:150340011 RPRD2 0.38 8.37 0.31 3.61e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7927771 0.864 rs7107726 chr11:47429245 T/A cg18512352 chr11:47633146 NA -0.33 -8.0 -0.3 5.8e-15 Subjective well-being; BRCA cis rs4268898 0.552 rs6754391 chr2:24369019 C/T cg26838691 chr2:24397539 C2orf84 -0.39 -8.01 -0.3 5.27e-15 Asthma; BRCA trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg15704280 chr7:45808275 SEPT13 -0.72 -14.84 -0.51 4.81e-43 Height; BRCA cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg05340658 chr4:99064831 C4orf37 0.59 12.11 0.43 1.63e-30 Colonoscopy-negative controls vs population controls; BRCA cis rs6820391 0.962 rs2280119 chr4:54415438 C/T cg04173182 chr4:54446035 LNX1 0.4 8.17 0.31 1.63e-15 Cervical artery dissection; BRCA cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.16 -0.58 1.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.6 -0.32 6e-17 Developmental language disorder (linguistic errors); BRCA trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg22491629 chr6:157744540 C6orf35 0.61 12.0 0.43 4.64e-30 Hemostatic factors and hematological phenotypes; BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg00814883 chr7:100076585 TSC22D4 -0.52 -11.78 -0.42 3.88e-29 Platelet count; BRCA cis rs9381107 0.505 rs9394957 chr6:9484928 C/G cg14735645 chr6:9486422 NA -0.45 -8.7 -0.33 2.75e-17 Nonsyndromic cleft lip with cleft palate; BRCA cis rs7927592 0.956 rs11228278 chr11:68308530 G/A cg20283391 chr11:68216788 NA -0.39 -7.88 -0.3 1.45e-14 Total body bone mineral density; BRCA cis rs6840360 0.571 rs6811676 chr4:152562726 T/C cg22705602 chr4:152727874 NA -0.33 -8.24 -0.31 9.6e-16 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg20503657 chr10:835505 NA 0.96 14.32 0.49 1.6e-40 Eosinophil percentage of granulocytes; BRCA cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg15017067 chr4:17643749 FAM184B -0.27 -8.05 -0.3 4.09e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg02659138 chr7:134003124 SLC35B4 0.34 10.67 0.39 1.46e-24 Mean platelet volume; BRCA cis rs10465746 0.780 rs6703493 chr1:84435812 G/A cg10977910 chr1:84465055 TTLL7 0.56 11.72 0.42 7.17e-29 Obesity-related traits; BRCA cis rs3768617 0.510 rs3768624 chr1:183079252 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA trans rs1459104 0.636 rs559362 chr11:55275456 T/G cg15704280 chr7:45808275 SEPT13 0.55 8.58 0.32 7.34e-17 Body mass index; BRCA cis rs13064411 0.696 rs9814395 chr3:113188885 C/T cg18753928 chr3:113234510 CCDC52 -0.53 -11.1 -0.4 2.69e-26 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg19077165 chr18:44547161 KATNAL2 -0.58 -12.77 -0.45 1.94e-33 Personality dimensions; BRCA cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg13852791 chr20:30311386 BCL2L1 0.84 16.43 0.55 7.17e-51 Mean corpuscular hemoglobin; BRCA cis rs1577917 1.000 rs12663690 chr6:86640162 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 12.48 0.44 3.76e-32 Response to antipsychotic treatment; BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.07 -0.43 2.23e-30 Gut microbiome composition (summer); BRCA cis rs1534166 0.647 rs9876158 chr3:133508300 T/C cg27366882 chr3:133540807 NA -0.32 -8.01 -0.3 5.51e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs13191362 0.938 rs35760705 chr6:163020637 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.59 0.42 2.59e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs6964833 0.935 rs34762099 chr7:74050694 T/C cg07504079 chr7:72649617 NCF1B -0.45 -8.65 -0.32 4.27e-17 Menarche (age at onset); BRCA cis rs2288073 0.801 rs6757275 chr2:24375230 A/G cg26838691 chr2:24397539 C2orf84 -0.43 -8.03 -0.3 4.72e-15 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg13334819 chr7:99746414 C7orf59 -0.43 -10.05 -0.37 3.76e-22 Coronary artery disease; BRCA trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg23533926 chr12:111358616 MYL2 -0.42 -8.77 -0.33 1.62e-17 Extrinsic epigenetic age acceleration; BRCA cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg01475377 chr6:109611718 NA -0.6 -16.64 -0.55 6.5e-52 Reticulocyte fraction of red cells; BRCA trans rs7916697 0.520 rs10762201 chr10:70040111 A/G cg04882175 chr6:131122610 NA 0.32 8.1 0.31 2.69e-15 Optic disc area; BRCA cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg01028140 chr2:1542097 TPO -0.58 -11.82 -0.42 2.63e-29 IgG glycosylation; BRCA trans rs61931739 0.517 rs11513277 chr12:34074799 G/T cg26384229 chr12:38710491 ALG10B 0.68 14.05 0.49 2.73e-39 Morning vs. evening chronotype; BRCA cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg20701182 chr2:24300061 SF3B14 0.54 8.42 0.32 2.55e-16 Lymphocyte counts; BRCA cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg18876405 chr7:65276391 NA -0.51 -11.52 -0.41 4.75e-28 Aortic root size; BRCA cis rs4853036 0.951 rs10185266 chr2:70152407 C/G cg02498382 chr2:70120550 SNRNP27 -0.52 -10.11 -0.37 2.21e-22 Colorectal or endometrial cancer; BRCA trans rs9325144 0.647 rs11168104 chr12:38857616 G/T cg23762105 chr12:34175262 ALG10 0.37 8.59 0.32 6.66e-17 Morning vs. evening chronotype; BRCA cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.84 -0.33 9.18e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs921968 0.541 rs687747 chr2:219399627 T/C cg02176678 chr2:219576539 TTLL4 0.46 11.92 0.43 9.84e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs7809950 0.862 rs12112877 chr7:106941324 T/C cg23024343 chr7:107201750 COG5 -0.38 -8.51 -0.32 1.26e-16 Coronary artery disease; BRCA cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg04756594 chr16:24857601 SLC5A11 -0.46 -9.22 -0.34 4.1e-19 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg27170947 chr2:26402098 FAM59B -0.67 -10.89 -0.4 1.81e-25 Gut microbiome composition (summer); BRCA cis rs4363385 0.747 rs6670614 chr1:152964338 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.64 -0.36 1.27e-20 Inflammatory skin disease; BRCA cis rs2836633 0.929 rs62217517 chr21:40033177 T/A cg05519781 chr21:40033154 ERG 0.46 9.83 0.36 2.38e-21 Coronary artery disease; BRCA cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs7246657 1.000 rs1529957 chr19:37739801 A/G cg23950597 chr19:37808831 NA -0.61 -10.78 -0.39 5.21e-25 Coronary artery calcification; BRCA cis rs1801251 0.711 rs778368 chr2:233745333 G/C cg08000102 chr2:233561755 GIGYF2 -0.46 -9.79 -0.36 3.47e-21 Coronary artery disease; BRCA cis rs2280018 0.526 rs2941257 chr16:15166445 T/C cg27102117 chr16:15229624 NA 0.42 10.05 0.37 3.72e-22 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg07395648 chr5:131743802 NA -0.38 -8.29 -0.31 6.7e-16 Breast cancer; BRCA cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs9640161 0.742 rs11767726 chr7:150018096 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 0.52 13.7 0.48 1.24e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs2832191 1.000 rs2832183 chr21:30482150 G/A cg24692254 chr21:30365293 RNF160 -0.59 -14.95 -0.51 1.48e-43 Dental caries; BRCA cis rs739401 0.611 rs572373 chr11:3055361 T/C cg08508325 chr11:3079039 CARS -0.45 -16.2 -0.54 1.06e-49 Longevity; BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg12311346 chr5:56204834 C5orf35 -0.75 -14.76 -0.5 1.21e-42 Initial pursuit acceleration; BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg08132940 chr7:1081526 C7orf50 -0.47 -8.4 -0.32 2.97e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg18225595 chr11:63971243 STIP1 0.5 9.27 0.34 2.72e-19 Attention deficit hyperactivity disorder; BRCA cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.92 0.6 9.45e-64 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs28735056 0.933 rs72980085 chr18:77631679 A/C cg20368463 chr18:77673604 PQLC1 -0.34 -8.0 -0.3 5.75e-15 Schizophrenia; BRCA cis rs698813 0.637 rs7579841 chr2:44498887 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.44 7.96 0.3 8.16e-15 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg16850897 chr7:100343110 ZAN -0.58 -12.25 -0.44 3.98e-31 Other erythrocyte phenotypes; BRCA cis rs28595532 0.920 rs116023902 chr4:119725131 A/G cg11846333 chr4:119757529 SEC24D 0.61 7.97 0.3 7.34e-15 Cannabis dependence symptom count; BRCA cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.37 0.66 2.62e-82 Chronic sinus infection; BRCA cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg12564285 chr5:131593104 PDLIM4 0.32 7.96 0.3 8.12e-15 Blood metabolite levels; BRCA trans rs9951602 0.512 rs12458828 chr18:76648522 C/T cg02800362 chr5:177631904 HNRNPAB -0.8 -18.73 -0.6 1.02e-62 Obesity-related traits; BRCA cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg08085267 chr17:45401833 C17orf57 0.6 12.31 0.44 2.05e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7301826 0.610 rs36051740 chr12:131292722 G/A cg11011512 chr12:131303247 STX2 -0.47 -12.01 -0.43 4.3e-30 Plasma plasminogen activator levels; BRCA trans rs17685 0.736 rs4732594 chr7:75753273 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4319547 0.956 rs7316149 chr12:123063912 G/A cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.17 -0.37 1.3e-22 Body mass index; BRCA cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg19077165 chr18:44547161 KATNAL2 -0.64 -14.85 -0.51 4.42e-43 Personality dimensions; BRCA trans rs9329221 0.620 rs6601427 chr8:10156025 A/G cg15556689 chr8:8085844 FLJ10661 -0.38 -10.38 -0.38 1.97e-23 Neuroticism; BRCA cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.32 0.38 3.48e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs400736 0.930 rs2745722 chr1:8056669 G/A cg25007680 chr1:8021821 PARK7 0.48 12.03 0.43 3.34e-30 Response to antidepressants and depression; BRCA cis rs634534 0.622 rs593525 chr11:65727799 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.37 9.01 0.34 2.35e-18 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs4808199 0.947 rs4808960 chr19:19574277 G/C cg03709012 chr19:19516395 GATAD2A 1.08 20.88 0.64 3.37e-74 Nonalcoholic fatty liver disease; BRCA cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg03213289 chr20:61660250 NA 0.61 16.24 0.54 6.67e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg13319975 chr6:146136371 FBXO30 -0.35 -8.12 -0.31 2.36e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7301826 1.000 rs4759793 chr12:131297238 A/G cg11011512 chr12:131303247 STX2 0.42 10.88 0.4 2.08e-25 Plasma plasminogen activator levels; BRCA cis rs10465746 0.747 rs34155960 chr1:84447539 T/G cg10977910 chr1:84465055 TTLL7 0.57 11.98 0.43 5.4e-30 Obesity-related traits; BRCA cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg20476274 chr7:133979776 SLC35B4 -0.65 -18.58 -0.59 6.06e-62 Mean platelet volume; BRCA trans rs4332037 0.851 rs73050128 chr7:1961882 C/A cg11693508 chr17:37793320 STARD3 0.71 13.47 0.47 1.44e-36 Bipolar disorder; BRCA cis rs56176327 0.600 rs7628207 chr3:49754970 T/C cg03060546 chr3:49711283 APEH 0.6 10.38 0.38 1.97e-23 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.49 -0.38 7.21e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2882667 0.931 rs10074461 chr5:138319815 G/T cg04439458 chr5:138467593 SIL1 -0.35 -9.84 -0.36 2.29e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg16414030 chr3:133502952 NA 0.54 13.02 0.46 1.58e-34 Iron status biomarkers; BRCA trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg21775007 chr8:11205619 TDH -0.39 -8.05 -0.3 4.11e-15 Neuroticism; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg00814883 chr7:100076585 TSC22D4 -0.55 -11.85 -0.42 2.08e-29 Platelet count; BRCA cis rs59698941 0.527 rs7719428 chr5:132180919 C/G cg14825688 chr5:132208181 LEAP2 0.35 8.08 0.3 3.14e-15 Apolipoprotein A-IV levels; BRCA cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg25554036 chr4:6271136 WFS1 0.41 9.72 0.36 6.57e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7267979 0.966 rs6050611 chr20:25414419 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 8.97 0.33 3.36e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9467773 0.620 rs2504567 chr6:26662920 C/G cg11502198 chr6:26597334 ABT1 0.56 12.03 0.43 3.53e-30 Intelligence (multi-trait analysis); BRCA cis rs2066819 1.000 rs77853814 chr12:56687572 G/T cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg18357526 chr6:26021779 HIST1H4A 0.51 9.49 0.35 4.57e-20 Intelligence (multi-trait analysis); BRCA cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg23029597 chr12:123009494 RSRC2 -0.61 -11.81 -0.42 3e-29 Body mass index; BRCA cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.48 0.35 4.92e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs2901460 0.509 rs12463815 chr2:62087165 C/T cg02183531 chr2:62113199 CCT4 -0.45 -8.81 -0.33 1.18e-17 Mean corpuscular volume; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -8.19 -0.31 1.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs826838 0.967 rs11169169 chr12:39093153 A/C cg26384229 chr12:38710491 ALG10B 0.82 21.62 0.65 3.19e-78 Heart rate; BRCA cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11644478 chr21:40555479 PSMG1 -0.68 -14.54 -0.5 1.39e-41 Cognitive function; BRCA cis rs265548 0.538 rs36688 chr19:17911212 A/C cg21960279 chr19:17905606 B3GNT3 0.5 11.37 0.41 2.12e-27 Tumor biomarkers; BRCA cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.88 -0.3 1.47e-14 Colorectal cancer; BRCA cis rs10883723 0.810 rs10883728 chr10:104269301 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.63 -19.76 -0.62 3.46e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs7715806 0.500 rs72633986 chr5:75006449 T/A cg19683494 chr5:74908142 NA 0.5 8.1 0.31 2.81e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs332507 0.830 rs4678144 chr3:124404399 C/T cg05980111 chr3:124395277 KALRN -0.37 -8.66 -0.32 3.73e-17 Plateletcrit; BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg16145915 chr7:1198662 ZFAND2A -0.43 -10.35 -0.38 2.64e-23 Longevity;Endometriosis; BRCA cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg17143192 chr8:8559678 CLDN23 0.56 10.8 0.39 4.26e-25 Obesity-related traits; BRCA cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg09035930 chr12:129282057 SLC15A4 0.5 13.99 0.48 5.46e-39 Systemic lupus erythematosus; BRCA cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg24562669 chr7:97807699 LMTK2 0.67 19.95 0.62 3.52e-69 Breast cancer; BRCA cis rs11608355 0.515 rs7310945 chr12:109946012 G/A cg05360138 chr12:110035743 NA 0.74 13.68 0.48 1.56e-37 Neuroticism; BRCA cis rs2836974 0.897 rs2836927 chr21:40543216 T/C cg11644478 chr21:40555479 PSMG1 0.83 18.88 0.6 1.63e-63 Cognitive function; BRCA cis rs6700896 0.931 rs1938497 chr1:66100450 G/A cg04111102 chr1:66153794 NA 0.33 8.23 0.31 1.09e-15 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs17095355 1.000 rs958086 chr10:111752548 G/T cg00817464 chr10:111662876 XPNPEP1 -0.4 -9.98 -0.37 6.53e-22 Biliary atresia; BRCA trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.24 0.44 4.06e-31 Corneal astigmatism; BRCA cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.13 -0.37 1.77e-22 Aortic root size; BRCA cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg18357526 chr6:26021779 HIST1H4A 0.47 8.65 0.32 4.1e-17 Intelligence (multi-trait analysis); BRCA cis rs3857067 0.806 rs6532472 chr4:95110113 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs9986765 1.000 rs28672333 chr7:142826798 G/A cg15652212 chr7:142981776 TMEM139 0.56 9.28 0.34 2.65e-19 Cancer;Dermatomyositis; BRCA cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.34 -0.49 1.29e-40 Chronic sinus infection; BRCA trans rs28735056 0.591 rs62101204 chr18:77712832 G/A cg05926928 chr17:57297772 GDPD1 0.4 7.93 0.3 9.53e-15 Schizophrenia; BRCA trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg15704280 chr7:45808275 SEPT13 -0.97 -27.88 -0.74 1.63e-112 Height; BRCA cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.32 -0.38 3.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2625529 0.617 rs8025939 chr15:72460339 T/A cg16672083 chr15:72433130 SENP8 0.66 16.15 0.54 1.76e-49 Red blood cell count; BRCA cis rs10751667 0.677 rs11246386 chr11:1044938 C/T ch.11.42038R chr11:967971 AP2A2 -0.38 -8.79 -0.33 1.33e-17 Alzheimer's disease (late onset); BRCA cis rs6456156 0.586 rs9457266 chr6:167482555 T/C cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs2070997 0.667 rs7851946 chr9:133719256 A/T cg11464064 chr9:133710261 ABL1 -0.48 -8.79 -0.33 1.38e-17 Response to amphetamines; BRCA cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg04586622 chr2:25135609 ADCY3 0.46 11.84 0.42 2.3e-29 Body mass index in non-asthmatics; BRCA cis rs9463078 0.845 rs9369514 chr6:44797271 C/A cg25276700 chr6:44698697 NA -0.37 -8.45 -0.32 1.94e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4790333 0.967 rs2002863 chr17:2269769 C/T cg02569219 chr17:2266849 SGSM2 0.45 10.92 0.4 1.46e-25 Proinsulin levels; BRCA cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg26384229 chr12:38710491 ALG10B 0.85 22.93 0.67 2.44e-85 Heart rate; BRCA cis rs11098499 0.863 rs11731756 chr4:120478696 T/G cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg03929089 chr4:120376271 NA -0.47 -9.04 -0.34 1.9e-18 HDL cholesterol; BRCA cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg08885076 chr2:99613938 TSGA10 -0.6 -13.12 -0.46 5.45e-35 Chronic sinus infection; BRCA cis rs1538970 0.816 rs34673142 chr1:45985561 G/A cg05343316 chr1:45956843 TESK2 0.71 14.38 0.49 8.1e-41 Platelet count; BRCA trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21659725 chr3:3221576 CRBN -0.45 -9.94 -0.37 9.89e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs35110281 0.720 rs162394 chr21:44943550 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -10.24 -0.38 6.82e-23 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg03146154 chr1:46216737 IPP 0.48 10.49 0.38 7.03e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg19784903 chr17:45786737 TBKBP1 0.34 8.26 0.31 8.68e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12950390 0.853 rs11655336 chr17:45858836 A/G cg03474202 chr17:45855739 NA 0.45 11.82 0.42 2.77e-29 IgG glycosylation; BRCA cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg17063962 chr7:91808500 NA -0.55 -12.32 -0.44 1.88e-31 Breast cancer; BRCA cis rs4363385 0.747 rs1577962 chr1:152962013 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.8 -0.33 1.3e-17 Inflammatory skin disease; BRCA cis rs72781680 1.000 rs115861480 chr2:24129464 T/A cg08917208 chr2:24149416 ATAD2B 1.11 15.76 0.53 1.69e-47 Lymphocyte counts; BRCA cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg18016565 chr1:150552671 MCL1 0.36 8.13 0.31 2.2e-15 Melanoma; BRCA cis rs4919694 0.611 rs75182663 chr10:105058104 A/G cg04362960 chr10:104952993 NT5C2 0.72 11.19 0.4 1.14e-26 Arsenic metabolism; BRCA cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs1003719 0.788 rs9981226 chr21:38452127 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.23e-40 Eye color traits; BRCA trans rs9467711 0.524 rs13216484 chr6:26762087 C/T cg01620082 chr3:125678407 NA -0.66 -8.19 -0.31 1.43e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs35740288 0.929 rs11630684 chr15:86306256 C/A cg20737812 chr15:86336631 KLHL25 -0.32 -7.95 -0.3 8.56e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs9304742 0.962 rs12150933 chr19:53455221 A/G cg24044776 chr19:53454761 ZNF816A -0.41 -9.29 -0.35 2.31e-19 Psoriasis; BRCA cis rs10754283 0.967 rs10737706 chr1:90112579 G/T cg21401794 chr1:90099060 LRRC8C 0.48 11.55 0.42 3.59e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs4363385 0.550 rs2050673 chr1:152923698 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.85 -0.3 1.79e-14 Inflammatory skin disease; BRCA cis rs6500602 0.767 rs8060219 chr16:4480158 T/A cg08645402 chr16:4508243 NA 0.37 8.77 0.33 1.65e-17 Schizophrenia; BRCA cis rs6570726 0.791 rs6570693 chr6:145910841 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -8.11 -0.31 2.52e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4906332 1.000 rs12879663 chr14:103874215 A/G cg26031613 chr14:104095156 KLC1 -0.44 -8.0 -0.3 5.88e-15 Coronary artery disease; BRCA cis rs11112613 0.775 rs10778413 chr12:105962118 G/A cg03607813 chr12:105948248 NA 0.59 10.29 0.38 4.31e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg13010199 chr12:38710504 ALG10B 0.42 8.81 0.33 1.16e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg04518342 chr5:131593106 PDLIM4 -0.38 -9.13 -0.34 8.91e-19 Acylcarnitine levels; BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.61 9.4 0.35 9.32e-20 Renal function-related traits (BUN); BRCA cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.87 0.48 2e-38 Coronary artery disease; BRCA cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 1.000 rs62036624 chr16:28839930 G/T cg16576597 chr16:28551801 NUPR1 0.29 8.27 0.31 7.65e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs614226 1.000 rs7174 chr12:121017171 A/G cg01236616 chr12:121019343 POP5 1.24 27.02 0.73 8.09e-108 Type 1 diabetes nephropathy; BRCA cis rs910316 0.967 rs4899549 chr14:75647494 G/A cg11812906 chr14:75593930 NEK9 -0.58 -13.02 -0.46 1.49e-34 Height; BRCA cis rs12431939 1.000 rs56220306 chr14:51648738 A/T cg23942311 chr14:51606299 NA -0.42 -7.95 -0.3 8.27e-15 Cancer; BRCA cis rs7586879 0.616 rs11900505 chr2:25131986 A/C cg04586622 chr2:25135609 ADCY3 0.47 11.94 0.43 8.18e-30 Body mass index; BRCA cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg21782813 chr7:2030301 MAD1L1 0.32 8.52 0.32 1.18e-16 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg18132916 chr6:79620363 NA -0.49 -10.98 -0.4 8.25e-26 Intelligence (multi-trait analysis); BRCA cis rs17401966 0.838 rs4333852 chr1:10387704 A/T cg03954927 chr1:10346856 KIF1B -0.42 -13.67 -0.48 1.65e-37 Hepatocellular carcinoma; BRCA cis rs9287719 0.839 rs12692415 chr2:10745474 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs1401999 1.000 rs7632670 chr3:183713877 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.11 0.37 2.26e-22 Anterior chamber depth; BRCA cis rs2230307 0.656 rs12145880 chr1:100446008 C/G cg24955406 chr1:100503596 HIAT1 0.54 9.38 0.35 1.18e-19 Carotid intima media thickness; BRCA cis rs9790314 0.846 rs6791213 chr3:161033721 A/G cg03342759 chr3:160939853 NMD3 -0.73 -18.23 -0.58 4.15e-60 Morning vs. evening chronotype; BRCA cis rs875971 0.545 rs73376394 chr7:65637681 C/T cg11764359 chr7:65958608 NA 0.62 11.22 0.41 8.61e-27 Aortic root size; BRCA cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg18850127 chr7:39170497 POU6F2 0.55 11.48 0.41 7.05e-28 IgG glycosylation; BRCA cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg01802117 chr1:53393560 SCP2 0.36 8.33 0.31 5.04e-16 Monocyte count; BRCA cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.658 rs4895683 chr6:146113654 T/A cg23711669 chr6:146136114 FBXO30 -0.72 -17.33 -0.57 1.9e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.43 0.52 6.96e-46 Colorectal cancer; BRCA cis rs12950390 0.512 rs11655306 chr17:45858744 C/T cg03474202 chr17:45855739 NA -0.45 -8.24 -0.31 9.58e-16 IgG glycosylation; BRCA cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.58 13.19 0.46 2.64e-35 Hemoglobin concentration; BRCA cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs10782582 0.586 rs12130324 chr1:76370012 A/G cg03433033 chr1:76189801 ACADM -0.39 -7.98 -0.3 6.58e-15 Daytime sleep phenotypes; BRCA cis rs344364 0.511 rs1742460 chr16:1945441 G/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.89 -0.36 1.48e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg00701064 chr4:6280414 WFS1 0.69 19.04 0.6 2.21e-64 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs28735056 1.000 rs59183289 chr18:77631198 A/G cg03682112 chr18:77623598 KCNG2 -0.38 -8.74 -0.33 1.98e-17 Schizophrenia; BRCA cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg27165867 chr14:105738592 BRF1 -0.36 -8.76 -0.33 1.77e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs9463078 0.774 rs9369558 chr6:45274021 A/C cg25276700 chr6:44698697 NA -0.35 -8.06 -0.3 3.7e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7264396 0.563 rs2425122 chr20:34328848 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs58235267 0.591 rs2162014 chr2:63345507 C/A cg17519650 chr2:63277830 OTX1 0.37 7.81 0.3 2.32e-14 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg01475377 chr6:109611718 NA -0.58 -15.92 -0.53 2.61e-48 Reticulocyte fraction of red cells; BRCA cis rs428668 0.523 rs3926389 chr5:150677806 C/T cg11125805 chr5:150678162 SLC36A3 0.73 19.65 0.61 1.34e-67 Skin aging (microtopography measurement); BRCA cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg01262667 chr19:19385393 TM6SF2 0.38 9.77 0.36 4.29e-21 Tonsillectomy; BRCA cis rs701145 0.585 rs921318 chr3:153856775 T/G cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA trans rs11098499 0.909 rs1809406 chr4:120377122 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.59 0.45 1.29e-32 Corneal astigmatism; BRCA cis rs17095355 1.000 rs11194920 chr10:111695412 G/T cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.89 -0.36 1.48e-21 Biliary atresia; BRCA cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.43 0.35 7.76e-20 Tonsillectomy; BRCA cis rs9527 0.590 rs10509766 chr10:104926334 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.15 0.37 1.55e-22 Arsenic metabolism; BRCA cis rs2425143 1.000 rs1970357 chr20:34339200 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.63 8.83 0.33 1e-17 Blood protein levels; BRCA cis rs3768617 0.510 rs6691755 chr1:183099821 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs61931739 0.517 rs7313663 chr12:34417058 T/C cg06521331 chr12:34319734 NA -0.51 -10.02 -0.37 4.68e-22 Morning vs. evening chronotype; BRCA cis rs7267979 0.816 rs443009 chr20:25499817 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.28 -7.96 -0.3 8.15e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs17270561 0.666 rs4712971 chr6:25771900 T/C cg17691542 chr6:26056736 HIST1H1C 0.57 10.95 0.4 1.13e-25 Iron status biomarkers; BRCA cis rs4285028 0.747 rs1128163 chr3:121350573 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.69 -13.47 -0.47 1.45e-36 Multiple sclerosis; BRCA cis rs7582180 0.629 rs11684516 chr2:100949883 C/A cg14675211 chr2:100938903 LONRF2 0.51 11.68 0.42 1.07e-28 Intelligence (multi-trait analysis); BRCA cis rs2346177 0.519 rs2121698 chr2:46709571 C/T cg02822958 chr2:46747628 ATP6V1E2 0.59 11.41 0.41 1.37e-27 HDL cholesterol; BRCA trans rs8062405 1.000 rs72793812 chr16:28840381 A/G cg09719594 chr16:21412588 NA -0.35 -7.97 -0.3 7.23e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg23978390 chr7:1156363 C7orf50 0.39 7.99 0.3 6.46e-15 Bronchopulmonary dysplasia; BRCA cis rs9388451 0.868 rs1268083 chr6:126049040 T/C cg05901451 chr6:126070800 HEY2 0.57 15.02 0.51 6.99e-44 Brugada syndrome; BRCA cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg08975724 chr8:8085496 FLJ10661 0.52 11.18 0.4 1.21e-26 Mood instability; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.34 11.78 0.42 4.16e-29 Systemic lupus erythematosus; BRCA cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg03433033 chr1:76189801 ACADM 0.75 17.23 0.56 6.46e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3741151 0.773 rs73544720 chr11:73173496 A/G cg17517138 chr11:73019481 ARHGEF17 0.87 12.39 0.44 9.72e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs2204008 0.678 rs61929520 chr12:38446800 T/C cg26384229 chr12:38710491 ALG10B -0.43 -10.0 -0.37 5.91e-22 Bladder cancer; BRCA cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg02659138 chr7:134003124 SLC35B4 0.34 10.77 0.39 5.91e-25 Mean platelet volume; BRCA cis rs12579753 0.879 rs1986537 chr12:82156475 G/C cg07988820 chr12:82153109 PPFIA2 -0.67 -11.22 -0.41 8.97e-27 Resting heart rate; BRCA cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg18479299 chr3:125709523 NA -0.54 -8.33 -0.31 4.84e-16 Blood pressure (smoking interaction); BRCA cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg26818010 chr10:134567672 INPP5A -0.66 -14.15 -0.49 9.81e-40 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs9944715 1.000 rs4890320 chr18:43814124 T/C cg01718231 chr17:29326311 RNF135 -0.46 -9.07 -0.34 1.51e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg12311346 chr5:56204834 C5orf35 -0.79 -15.95 -0.53 1.96e-48 Initial pursuit acceleration; BRCA cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs367943 0.698 rs2115208 chr5:112973994 A/G cg12552261 chr5:112820674 MCC 0.37 7.88 0.3 1.41e-14 Type 2 diabetes; BRCA cis rs1215050 0.740 rs13134479 chr4:99067723 G/A cg05340658 chr4:99064831 C4orf37 0.48 11.11 0.4 2.54e-26 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6963495 0.818 rs117887993 chr7:105193837 T/G cg19920283 chr7:105172520 RINT1 0.59 9.28 0.34 2.58e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg26647111 chr11:31128758 NA -0.45 -9.92 -0.37 1.15e-21 Red blood cell count; BRCA cis rs4664304 0.649 rs12692570 chr2:160726599 C/T cg14819504 chr2:160761413 LY75 0.32 8.1 0.31 2.83e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -8.6 -0.32 6.36e-17 Glomerular filtration rate (creatinine); BRCA trans rs3857536 0.707 rs9345793 chr6:66929807 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.04 -0.3 4.28e-15 Blood trace element (Cu levels); BRCA cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.4 0.63 1.35e-71 Smoking behavior; BRCA cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg18964960 chr10:1102726 WDR37 0.59 8.0 0.3 5.7e-15 Eosinophil percentage of granulocytes; BRCA cis rs72772090 0.539 rs10515249 chr5:96125259 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg22906224 chr7:99728672 NA 0.45 8.63 0.32 4.75e-17 Coronary artery disease; BRCA cis rs4363385 0.714 rs4845329 chr1:152974454 G/C cg25856811 chr1:152973957 SPRR3 -0.35 -9.3 -0.35 2.24e-19 Inflammatory skin disease; BRCA cis rs9815354 1.000 rs73081364 chr3:41913616 G/C cg03022575 chr3:42003672 ULK4 0.51 8.31 0.31 5.54e-16 Pulse pressure;Diastolic blood pressure; BRCA cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg22029157 chr1:209979665 IRF6 0.53 11.96 0.43 6.96e-30 Cleft lip with or without cleft palate; BRCA cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg13319975 chr6:146136371 FBXO30 -0.63 -14.62 -0.5 5.47e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg08807101 chr21:30365312 RNF160 -0.56 -13.35 -0.47 5.07e-36 Dental caries; BRCA cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg17971929 chr21:40555470 PSMG1 0.81 19.6 0.61 2.36e-67 Cognitive function; BRCA cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg20701182 chr2:24300061 SF3B14 0.71 13.18 0.46 2.82e-35 Lymphocyte counts; BRCA cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg04546413 chr19:29218101 NA 0.49 8.36 0.31 3.87e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg12311346 chr5:56204834 C5orf35 1.01 20.24 0.62 9.81e-71 Initial pursuit acceleration; BRCA trans rs11098499 0.913 rs13126596 chr4:120140729 A/G cg25214090 chr10:38739885 LOC399744 0.53 10.82 0.39 3.7e-25 Corneal astigmatism; BRCA cis rs7192750 0.583 rs8046916 chr16:72047751 C/G cg14768367 chr16:72042858 DHODH -0.56 -9.15 -0.34 7.26e-19 LDL cholesterol levels;Total cholesterol levels; BRCA cis rs4719841 0.662 rs9639523 chr7:25991977 A/C cg10085138 chr7:25991722 NA 0.3 8.43 0.32 2.23e-16 Triglyceride levels; BRCA trans rs11098499 0.954 rs3733524 chr4:120423729 T/C cg25214090 chr10:38739885 LOC399744 0.55 11.73 0.42 6.63e-29 Corneal astigmatism; BRCA cis rs7072216 0.763 rs10883091 chr10:100167239 C/T cg26618903 chr10:100175079 PYROXD2 -0.31 -8.9 -0.33 5.54e-18 Metabolite levels; BRCA cis rs2204008 0.549 rs12312109 chr12:38228251 G/T cg26384229 chr12:38710491 ALG10B -0.44 -9.85 -0.36 2.09e-21 Bladder cancer; BRCA cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg02659138 chr7:134003124 SLC35B4 0.36 10.3 0.38 4.02e-23 Mean platelet volume; BRCA cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg06115741 chr20:33292138 TP53INP2 0.49 10.92 0.4 1.49e-25 Coronary artery disease; BRCA cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA trans rs1493916 1.000 rs7238717 chr18:31395186 C/T cg27147174 chr7:100797783 AP1S1 -0.55 -11.05 -0.4 4.11e-26 Life satisfaction; BRCA cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg14349672 chr11:133703707 NA -0.35 -8.66 -0.32 3.72e-17 Childhood ear infection; BRCA cis rs78663649 0.908 rs113779505 chr19:16527982 G/A cg05286348 chr19:16641544 CHERP -0.72 -9.75 -0.36 4.81e-21 White blood cell count; BRCA cis rs7647973 0.593 rs1799844 chr3:49847642 G/A cg03060546 chr3:49711283 APEH -0.57 -8.96 -0.33 3.6e-18 Menarche (age at onset); BRCA cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg24112000 chr20:60950667 NA 0.47 9.93 0.37 1.08e-21 Colorectal cancer; BRCA trans rs141342723 1 rs141342723 chr6:27622084 T/C cg06606381 chr12:133084897 FBRSL1 -0.86 -8.5 -0.32 1.31e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs13082711 0.911 rs2887926 chr3:27494475 T/C cg02860705 chr3:27208620 NA 0.53 10.56 0.39 3.86e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg24308560 chr3:49941425 MST1R -0.4 -8.52 -0.32 1.16e-16 Intelligence (multi-trait analysis); BRCA cis rs11718455 0.960 rs13081767 chr3:44004468 T/C cg08738300 chr3:44038990 NA 0.46 8.86 0.33 8.12e-18 Coronary artery disease; BRCA cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg08280861 chr8:58055591 NA -0.51 -8.25 -0.31 8.82e-16 Developmental language disorder (linguistic errors); BRCA trans rs9951602 0.512 rs8098115 chr18:76653986 G/T cg02800362 chr5:177631904 HNRNPAB 0.78 18.28 0.59 2.25e-60 Obesity-related traits; BRCA cis rs344364 0.511 rs2982446 chr16:1947153 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.8 -0.36 3.23e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg00745463 chr17:30367425 LRRC37B -0.54 -8.94 -0.33 4.03e-18 Hip circumference adjusted for BMI; BRCA cis rs6542838 0.641 rs12712042 chr2:99534401 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -9.66 -0.36 1.05e-20 Fear of minor pain; BRCA cis rs7267979 0.966 rs4815425 chr20:25398876 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.01 -0.34 2.35e-18 Liver enzyme levels (alkaline phosphatase); BRCA trans rs9354352 0.935 rs7766730 chr6:66697003 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 13.23 0.46 1.68e-35 Initial pursuit acceleration in psychotic disorders; BRCA cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg20701182 chr2:24300061 SF3B14 0.67 9.77 0.36 4.33e-21 Lymphocyte counts; BRCA cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg17366294 chr4:99064904 C4orf37 0.44 10.31 0.38 3.57e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs2262909 0.962 rs425781 chr19:22229306 A/G cg17074339 chr11:11642133 GALNTL4 -0.43 -8.4 -0.32 3e-16 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs13046373 0.535 rs1911571 chr21:32031538 A/C cg06468780 chr21:31798236 KRTAP13-3 0.34 8.47 0.32 1.65e-16 HDL cholesterol; BRCA cis rs4722166 0.695 rs4722177 chr7:22798531 T/C cg26061582 chr7:22766209 IL6 0.35 8.2 0.31 1.34e-15 Lung cancer; BRCA cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg11752832 chr7:134001865 SLC35B4 -0.52 -12.26 -0.44 3.58e-31 Mean platelet volume; BRCA cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg19077165 chr18:44547161 KATNAL2 -0.58 -12.83 -0.45 1.05e-33 Personality dimensions; BRCA cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg19678392 chr7:94953810 PON1 -0.43 -8.96 -0.33 3.42e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs12347191 0.500 rs907578 chr9:100622883 A/G cg13688889 chr9:100608707 NA -0.48 -9.76 -0.36 4.62e-21 Orofacial clefts; BRCA cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg12927641 chr6:109611667 NA 0.37 9.24 0.34 3.48e-19 Reticulocyte fraction of red cells; BRCA cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.62e-21 Colorectal cancer; BRCA cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg13010199 chr12:38710504 ALG10B 0.53 11.06 0.4 4.06e-26 Heart rate; BRCA cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg18016565 chr1:150552671 MCL1 0.35 8.41 0.32 2.67e-16 Tonsillectomy; BRCA cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.98 -0.33 3.08e-18 Alzheimer's disease (late onset); BRCA cis rs1215050 0.765 rs783925 chr4:98969881 T/C cg05340658 chr4:99064831 C4orf37 -0.49 -11.35 -0.41 2.46e-27 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6598955 0.585 rs12138111 chr1:26590432 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.92 0.33 4.77e-18 Obesity-related traits; BRCA trans rs330048 0.545 rs11774353 chr8:9153127 C/T cg15556689 chr8:8085844 FLJ10661 0.4 9.98 0.37 6.59e-22 Systemic lupus erythematosus; BRCA cis rs507080 0.922 rs555356 chr11:118558078 G/T cg09144398 chr11:118550485 TREH -0.38 -9.08 -0.34 1.37e-18 Serum metabolite levels; BRCA cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg23711669 chr6:146136114 FBXO30 0.69 16.02 0.54 7.97e-49 Lobe attachment (rater-scored or self-reported); BRCA trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs12474201 0.894 rs4952842 chr2:46925730 C/A cg06386533 chr2:46925753 SOCS5 0.91 19.72 0.62 5.41e-68 Height; BRCA cis rs12893597 0.821 rs12896434 chr14:76816746 C/T cg20290672 chr14:76816747 NA -0.36 -7.81 -0.3 2.37e-14 Maximal oxygen uptake response; BRCA cis rs16958440 0.867 rs75808931 chr18:44693042 C/T cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA trans rs7980799 0.649 rs10772088 chr12:33663849 A/T cg26384229 chr12:38710491 ALG10B -0.52 -10.91 -0.4 1.6e-25 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg01448562 chr3:133502909 NA 0.61 14.41 0.5 6.03e-41 Iron status biomarkers; BRCA cis rs736801 0.504 rs2070721 chr5:131825842 T/G cg21138405 chr5:131827807 IRF1 0.33 10.43 0.38 1.25e-23 Breast cancer;Mosquito bite size; BRCA cis rs9790314 0.967 rs463928 chr3:161087734 A/T cg04691961 chr3:161091175 C3orf57 -0.64 -16.65 -0.55 5.99e-52 Morning vs. evening chronotype; BRCA cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg20387954 chr3:183756860 HTR3D -0.45 -10.04 -0.37 3.88e-22 Anterior chamber depth; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg19913688 chr11:428466 ANO9 -0.71 -10.09 -0.37 2.59e-22 Body mass index; BRCA trans rs11098499 0.863 rs3822192 chr4:120445720 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 7.84 0.3 1.9e-14 Corneal astigmatism; BRCA cis rs713587 0.525 rs11687089 chr2:25082926 T/C cg04586622 chr2:25135609 ADCY3 0.42 10.79 0.39 4.73e-25 Body mass index in non-asthmatics; BRCA trans rs11039798 0.588 rs11039818 chr11:48562120 C/T cg15704280 chr7:45808275 SEPT13 0.5 8.63 0.32 4.95e-17 Axial length; BRCA trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.31 -8.3 -0.31 6.15e-16 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.811 rs12368410 chr12:38305705 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.66 0.36 1.03e-20 Bladder cancer; BRCA cis rs12477438 0.798 rs6705583 chr2:99602625 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.81 -0.51 7.19e-43 Chronic sinus infection; BRCA cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg13736514 chr6:26305472 NA -0.35 -11.99 -0.43 4.93e-30 Educational attainment; BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.04 18.98 0.6 4.56e-64 Platelet count; BRCA cis rs2070488 0.965 rs4679053 chr3:38523495 G/T cg24069376 chr3:38537580 EXOG 0.42 11.98 0.43 5.45e-30 Electrocardiographic conduction measures; BRCA cis rs826838 0.933 rs980573 chr12:39127811 T/C cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA trans rs9858542 0.953 rs9811982 chr3:49624377 A/C cg21659725 chr3:3221576 CRBN -0.47 -10.21 -0.37 9.35e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs509477 1.000 rs11660848 chr18:32574010 T/C cg23791764 chr18:32556832 MAPRE2 -0.34 -7.88 -0.3 1.42e-14 Cerebrospinal fluid AB1-42 levels; BRCA cis rs1008375 1.000 rs2058337 chr4:17678649 C/T cg16339924 chr4:17578868 LAP3 0.57 14.15 0.49 1e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs3824867 0.920 rs7108143 chr11:47453722 T/G cg20307385 chr11:47447363 PSMC3 -0.51 -11.51 -0.41 5.63e-28 Mean corpuscular hemoglobin; BRCA cis rs2404602 0.530 rs11072614 chr15:76967205 G/A cg23625390 chr15:77176239 SCAPER -0.55 -12.65 -0.45 7e-33 Blood metabolite levels; BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs116095464 0.558 rs56298907 chr5:283280 C/A cg22496380 chr5:211416 CCDC127 -1.0 -14.08 -0.49 1.99e-39 Breast cancer; BRCA cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg14092988 chr3:52407081 DNAH1 0.33 7.87 0.3 1.51e-14 Bipolar disorder; BRCA cis rs2294693 0.947 rs736793 chr6:40997919 A/T cg14418226 chr6:40996092 UNC5CL 0.45 8.35 0.31 4.32e-16 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12667521 chr19:29218732 NA 0.42 8.32 0.31 5.22e-16 Methadone dose in opioid dependence; BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.96 -0.3 8.15e-15 Total body bone mineral density; BRCA cis rs9633740 1.000 rs7922621 chr10:82251544 C/A cg00277334 chr10:82204260 NA -0.48 -8.09 -0.3 2.93e-15 Post bronchodilator FEV1; BRCA cis rs7640424 0.618 rs35798995 chr3:107914313 G/A cg09227934 chr3:107805635 CD47 -0.38 -7.88 -0.3 1.39e-14 Body mass index; BRCA cis rs5758659 0.652 rs133321 chr22:42405322 A/G cg15557168 chr22:42548783 NA -0.31 -8.58 -0.32 7.15e-17 Cognitive function; BRCA cis rs4478858 0.735 rs6676682 chr1:31809816 C/T cg00250761 chr1:31883323 NA -0.33 -8.54 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg08219700 chr8:58056026 NA 0.45 8.32 0.31 5.3e-16 Developmental language disorder (linguistic errors); BRCA cis rs782590 0.774 rs782637 chr2:55894247 T/C cg18811423 chr2:55921094 PNPT1 0.78 26.56 0.72 2.64e-105 Metabolic syndrome; BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg08888203 chr3:10149979 C3orf24 0.67 14.48 0.5 2.56e-41 Alzheimer's disease; BRCA cis rs3784262 1.000 rs7165247 chr15:58251786 C/T cg12031962 chr15:58353849 ALDH1A2 0.47 12.89 0.45 5.8e-34 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg23358479 chr7:1110784 C7orf50 -0.49 -8.2 -0.31 1.27e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10046574 0.831 rs17403220 chr7:135191705 A/G cg27474649 chr7:135195673 CNOT4 0.63 9.16 0.34 7.22e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9462846 1.000 rs9471942 chr6:42861532 C/T cg02353165 chr6:42928485 GNMT 0.48 8.61 0.32 5.61e-17 Blood protein levels; BRCA cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.12 -0.37 1.97e-22 IgG glycosylation; BRCA cis rs208520 0.802 rs208516 chr6:66946119 T/C cg07460842 chr6:66804631 NA -0.89 -15.83 -0.53 7.13e-48 Exhaled nitric oxide output; BRCA cis rs6138458 1.000 rs227629 chr20:24913551 G/T cg26195577 chr20:24973756 C20orf3 0.98 24.67 0.7 6.47e-95 Blood protein levels; BRCA cis rs1691799 0.863 rs1168291 chr12:66732488 T/C cg16791601 chr12:66731901 HELB -0.65 -17.57 -0.57 1.16e-56 White blood cell count (basophil); BRCA cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg22431228 chr1:16359049 CLCNKA -0.5 -11.1 -0.4 2.65e-26 Systolic blood pressure; BRCA cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 8.22 0.31 1.18e-15 Personality dimensions; BRCA cis rs868036 0.609 rs13329413 chr15:68097126 C/T cg05925327 chr15:68127851 NA -0.44 -9.48 -0.35 4.78e-20 Restless legs syndrome; BRCA cis rs9815354 0.812 rs17284313 chr3:41986787 G/T cg03022575 chr3:42003672 ULK4 -0.69 -9.69 -0.36 8.4e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs7011049 1.000 rs72640863 chr8:53841706 A/T cg26025543 chr8:53854495 NA 0.55 9.64 0.36 1.29e-20 Systolic blood pressure; BRCA cis rs13394619 1.000 rs2358040 chr2:11731774 G/T cg07314298 chr2:11723111 GREB1 0.53 12.09 0.43 1.93e-30 Endometriosis; BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg03354898 chr7:1950403 MAD1L1 -0.48 -9.48 -0.35 4.89e-20 Bipolar disorder and schizophrenia; BRCA cis rs6582630 0.503 rs4882293 chr12:38388200 G/C cg26384229 chr12:38710491 ALG10B -0.43 -9.98 -0.37 6.74e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg13902645 chr11:5959945 NA -0.54 -10.85 -0.39 2.78e-25 DNA methylation (variation); BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 16.12 0.54 2.62e-49 Platelet count; BRCA cis rs7659604 0.728 rs3924987 chr4:122689784 G/T cg19748678 chr4:122722346 EXOSC9 0.69 14.05 0.49 3e-39 Type 2 diabetes; BRCA cis rs7582180 0.629 rs13031508 chr2:100952757 A/G cg08017756 chr2:100939284 LONRF2 -0.32 -8.23 -0.31 1.02e-15 Intelligence (multi-trait analysis); BRCA cis rs910316 0.935 rs175448 chr14:75591071 G/A cg08847533 chr14:75593920 NEK9 -0.87 -22.33 -0.66 4.66e-82 Height; BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg00149659 chr3:10157352 C3orf10 0.79 13.71 0.48 1.05e-37 Alzheimer's disease; BRCA cis rs6867032 0.527 rs13153217 chr5:2012788 G/T cg26168224 chr5:2018326 NA -0.39 -10.6 -0.39 2.77e-24 Gut microbiome composition (winter); BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg11062466 chr8:58055876 NA 0.54 9.08 0.34 1.34e-18 Developmental language disorder (linguistic errors); BRCA trans rs877282 0.891 rs11253355 chr10:768367 C/G cg22713356 chr15:30763199 NA 1.36 27.11 0.73 2.72e-108 Uric acid levels; BRCA cis rs832540 0.669 rs832539 chr5:56199386 A/C cg20203395 chr5:56204925 C5orf35 -0.36 -8.17 -0.31 1.68e-15 Coronary artery disease; BRCA cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg02772935 chr3:125709198 NA -0.47 -7.96 -0.3 7.6e-15 Blood pressure (smoking interaction); BRCA cis rs2625529 0.824 rs12439900 chr15:72373640 A/G cg16672083 chr15:72433130 SENP8 -0.84 -17.86 -0.58 3.45e-58 Red blood cell count; BRCA cis rs898097 0.841 rs2271918 chr17:80861206 A/G cg15369054 chr17:80825471 TBCD 0.57 12.96 0.46 2.8e-34 Breast cancer; BRCA cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg20891283 chr12:69753455 YEATS4 0.73 21.96 0.66 4.86e-80 Blood protein levels; BRCA cis rs9914988 0.943 rs9898892 chr17:27150750 T/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.77 -0.33 1.66e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs3806843 0.762 rs3756337 chr5:140186438 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.39 -8.57 -0.32 7.85e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg24110177 chr3:50126178 RBM5 -0.37 -10.04 -0.37 3.92e-22 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.534 rs4001713 chr12:34154195 A/C cg26384229 chr12:38710491 ALG10B -0.66 -13.92 -0.48 1.19e-38 Morning vs. evening chronotype; BRCA cis rs12142240 0.698 rs66483119 chr1:46838389 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -9.44 -0.35 7.1e-20 Menopause (age at onset); BRCA cis rs2370759 1.000 rs11008865 chr10:32574842 C/T cg01819863 chr10:32635814 EPC1 1.16 20.46 0.63 6.39e-72 Sexual dysfunction (female); BRCA cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.29e-16 Schizophrenia; BRCA cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg22153463 chr1:85462885 MCOLN2 -0.57 -10.2 -0.37 1.01e-22 Serum sulfate level; BRCA cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.71 9.93 0.37 1.09e-21 Initial pursuit acceleration; BRCA cis rs8017423 0.874 rs4900029 chr14:90686257 T/A cg04374321 chr14:90722782 PSMC1 0.72 18.48 0.59 2.03e-61 Mortality in heart failure; BRCA cis rs1577917 0.876 rs4618490 chr6:86518403 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.07 -0.43 2.37e-30 Response to antipsychotic treatment; BRCA cis rs6964587 1.000 rs12537846 chr7:91721581 C/T cg01689657 chr7:91764605 CYP51A1 -0.22 -7.96 -0.3 7.92e-15 Breast cancer; BRCA cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg19678392 chr7:94953810 PON1 -0.43 -9.18 -0.34 5.82e-19 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4906332 1.000 rs3783398 chr14:103949378 C/T cg04998671 chr14:104000505 TRMT61A 0.44 9.73 0.36 5.95e-21 Coronary artery disease; BRCA cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg20933634 chr6:27740509 NA 0.47 9.34 0.35 1.64e-19 Parkinson's disease; BRCA cis rs6684514 1.000 rs12023704 chr1:156294149 C/A cg16558208 chr1:156270281 VHLL 0.36 8.16 0.31 1.78e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9368481 0.761 rs6918835 chr6:27017827 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.24 -7.94 -0.3 9.04e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs2274273 0.840 rs6573020 chr14:55871452 C/T cg04306507 chr14:55594613 LGALS3 0.29 8.37 0.31 3.68e-16 Protein biomarker; BRCA cis rs4808199 0.895 rs12981405 chr19:19651577 C/T cg03709012 chr19:19516395 GATAD2A 1.06 19.7 0.61 7.64e-68 Nonalcoholic fatty liver disease; BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg27170947 chr2:26402098 FAM59B 0.92 16.89 0.56 3.63e-53 Gut microbiome composition (summer); BRCA cis rs10752881 1.000 rs10797808 chr1:182979623 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg00166722 chr3:10149974 C3orf24 -0.61 -12.36 -0.44 1.32e-31 Alzheimer's disease; BRCA cis rs9733 0.566 rs72702554 chr1:150678234 A/G cg04414720 chr1:150670196 GOLPH3L 0.35 7.94 0.3 9.29e-15 Tonsillectomy; BRCA cis rs7264396 0.790 rs3787166 chr20:34229072 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.69 -13.7 -0.48 1.27e-37 Total cholesterol levels; BRCA cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg04455712 chr21:45112962 RRP1B 0.43 10.91 0.4 1.61e-25 Mean corpuscular volume; BRCA cis rs34779708 0.931 rs7099036 chr10:35349574 C/T cg03585969 chr10:35415529 CREM 0.5 10.4 0.38 1.59e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4845570 0.831 rs11588258 chr1:151780728 A/T cg07092448 chr1:151763213 TDRKH -0.79 -13.6 -0.47 3.54e-37 Coronary artery disease; BRCA cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.46 -0.44 4.72e-32 Bipolar disorder; BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg11843238 chr5:131593191 PDLIM4 0.36 9.43 0.35 7.53e-20 Breast cancer; BRCA cis rs3733585 0.664 rs17185870 chr4:9958214 C/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.45 -0.38 1.05e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7762018 1.000 rs74900588 chr6:170102180 A/C cg19338460 chr6:170058176 WDR27 -0.45 -8.03 -0.3 4.64e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs600231 0.708 rs3132767 chr11:65234860 C/T cg01292856 chr11:65242576 NA 0.32 8.15 0.31 1.86e-15 Bone mineral density; BRCA cis rs34779708 0.931 rs12773169 chr10:35366462 G/C cg03585969 chr10:35415529 CREM 0.5 10.44 0.38 1.16e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.72 -0.33 2.48e-17 Monocyte percentage of white cells; BRCA cis rs9880211 1.000 rs9883189 chr3:136289466 T/C cg21827317 chr3:136751795 NA -0.44 -7.94 -0.3 8.89e-15 Body mass index;Height; BRCA cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg20307385 chr11:47447363 PSMC3 -0.41 -8.75 -0.33 1.87e-17 Subjective well-being; BRCA cis rs3768617 0.510 rs4652776 chr1:183091920 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.08e-57 Fuchs's corneal dystrophy; BRCA cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.95e-38 Mean platelet volume; BRCA cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg15704280 chr7:45808275 SEPT13 0.63 11.24 0.41 6.97e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs7552404 1.000 rs11161521 chr1:76216330 T/C cg22875332 chr1:76189707 ACADM 0.69 14.57 0.5 9.55e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs950169 0.519 rs7237 chr15:85186577 C/T cg12863693 chr15:85201151 NMB 0.52 10.98 0.4 8.49e-26 Schizophrenia; BRCA cis rs6831352 0.840 rs29001223 chr4:100047433 C/T cg13256891 chr4:100009986 ADH5 -0.53 -9.87 -0.36 1.82e-21 Alcohol dependence; BRCA cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg01475377 chr6:109611718 NA -0.51 -13.13 -0.46 4.95e-35 Reticulocyte fraction of red cells; BRCA cis rs2882667 0.931 rs7706391 chr5:138349164 G/A cg04439458 chr5:138467593 SIL1 -0.36 -9.76 -0.36 4.54e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 0.830 rs778715 chr7:65849209 C/T cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.5e-55 Aortic root size; BRCA cis rs965469 1.000 rs6051763 chr20:3321616 T/G cg25506879 chr20:3388711 C20orf194 -0.55 -10.84 -0.39 3.09e-25 IFN-related cytopenia; BRCA cis rs367943 0.608 rs4705564 chr5:112980196 G/C cg12552261 chr5:112820674 MCC 0.37 8.01 0.3 5.27e-15 Type 2 diabetes; BRCA cis rs4642101 0.694 rs12631514 chr3:12838293 G/C cg24848339 chr3:12840334 CAND2 0.51 13.55 0.47 5.77e-37 QRS complex (12-leadsum); BRCA cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg05283184 chr6:79620031 NA -0.43 -10.99 -0.4 7.76e-26 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg20607798 chr8:58055168 NA 0.48 8.33 0.31 4.87e-16 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg16339924 chr4:17578868 LAP3 0.57 14.06 0.49 2.45e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg13073564 chr4:8508604 NA -0.44 -12.01 -0.43 4.27e-30 Response to antineoplastic agents; BRCA cis rs2835872 0.758 rs1787398 chr21:39037504 A/C cg06728970 chr21:39037746 KCNJ6 0.45 12.93 0.46 3.95e-34 Electroencephalographic traits in alcoholism; BRCA trans rs61931739 0.534 rs7310499 chr12:34212112 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.58 0.35 2.14e-20 Morning vs. evening chronotype; BRCA trans rs9858542 0.953 rs9837341 chr3:49664767 A/G cg21659725 chr3:3221576 CRBN -0.48 -10.35 -0.38 2.53e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs877282 0.891 rs11253393 chr10:788824 G/T cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs7586673 1.000 rs16845584 chr2:161923830 C/T cg16506815 chr2:162101123 NA -0.48 -10.17 -0.37 1.24e-22 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10911251 0.528 rs10911255 chr1:183088868 G/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Colorectal cancer; BRCA cis rs17376456 0.877 rs10052428 chr5:93476530 T/C cg21475434 chr5:93447410 FAM172A 0.69 8.96 0.33 3.56e-18 Diabetic retinopathy; BRCA cis rs36051895 0.623 rs10283467 chr9:5244356 C/G cg02405213 chr9:5042618 JAK2 0.42 8.02 0.3 4.89e-15 Pediatric autoimmune diseases; BRCA cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.08e-18 Developmental language disorder (linguistic errors); BRCA cis rs7917772 0.503 rs7893155 chr10:104294228 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11608355 0.515 rs34038572 chr12:109901657 A/G cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs2637266 1.000 rs6480827 chr10:78356333 T/G cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs12618769 0.597 rs4851131 chr2:99036802 A/C cg10123293 chr2:99228465 UNC50 0.41 8.11 0.31 2.52e-15 Bipolar disorder; BRCA trans rs961253 0.522 rs2225115 chr20:6360465 C/T cg21095983 chr6:86352623 SYNCRIP 0.38 7.87 0.3 1.53e-14 Colorectal cancer; BRCA cis rs7011049 1.000 rs6988927 chr8:53837496 T/C cg26025543 chr8:53854495 NA 0.54 9.53 0.35 3.26e-20 Systolic blood pressure; BRCA cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.89 0.36 1.43e-21 Tonsillectomy; BRCA cis rs3768617 0.740 rs28533496 chr1:183019885 G/T ch.1.3577855R chr1:183094577 LAMC1 0.44 9.7 0.36 7.76e-21 Fuchs's corneal dystrophy; BRCA cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -11.6 -0.42 2.19e-28 Schizophrenia; BRCA cis rs2066819 1.000 rs78149779 chr12:56694817 A/G cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs427394 0.735 rs416689 chr5:6740855 C/T cg10857441 chr5:6722123 POLS -0.34 -11.18 -0.4 1.27e-26 Menopause (age at onset); BRCA cis rs2463822 1.000 rs2513052 chr11:62108248 C/G cg06239285 chr11:62104954 ASRGL1 0.69 11.68 0.42 1.05e-28 Chronic obstructive pulmonary disease-related biomarkers; BRCA trans rs561341 0.943 rs508566 chr17:30289861 G/C cg27661571 chr11:113659931 NA -0.69 -10.61 -0.39 2.52e-24 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg05340658 chr4:99064831 C4orf37 0.54 8.92 0.33 4.99e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs7246967 0.551 rs7257333 chr19:22881149 C/T cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg22920501 chr2:26401640 FAM59B 0.95 16.66 0.55 4.8e-52 Gut microbiome composition (summer); BRCA cis rs10876993 0.855 rs1689604 chr12:58048304 T/C cg00677455 chr12:58241039 CTDSP2 -0.35 -7.95 -0.3 8.42e-15 Celiac disease or Rheumatoid arthritis; BRCA cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg07507251 chr3:52567010 NT5DC2 0.39 9.39 0.35 1.06e-19 Electroencephalogram traits; BRCA cis rs925228 0.550 rs7568163 chr2:24278841 T/G cg20701182 chr2:24300061 SF3B14 -0.46 -9.57 -0.35 2.32e-20 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.49 0.35 4.65e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA trans rs11098499 0.954 rs13107475 chr4:120393011 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.29e-14 Corneal astigmatism; BRCA cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.62 -0.45 9.47e-33 Bipolar disorder; BRCA cis rs12681288 0.823 rs2701906 chr8:1003316 T/C cg04851639 chr8:1020857 NA -0.36 -11.01 -0.4 6.48e-26 Schizophrenia; BRCA cis rs910316 0.967 rs175498 chr14:75536369 G/A cg08847533 chr14:75593920 NEK9 -0.85 -21.38 -0.65 6.31e-77 Height; BRCA cis rs6738485 0.552 rs62146770 chr2:106854277 C/T cg16099169 chr2:106886729 NA -0.42 -9.04 -0.34 1.9e-18 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA cis rs2282802 0.635 rs397463 chr5:139584275 C/G cg26211634 chr5:139558579 C5orf32 -0.34 -8.35 -0.31 4.34e-16 Intelligence (multi-trait analysis); BRCA cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12756686 chr19:29218302 NA 0.59 11.77 0.42 4.24e-29 Methadone dose in opioid dependence; BRCA cis rs4919694 0.901 rs74376228 chr10:104677662 G/C cg04362960 chr10:104952993 NT5C2 0.99 13.51 0.47 9.53e-37 Arsenic metabolism; BRCA cis rs9807989 0.507 rs1833174 chr2:103034843 T/A cg03938978 chr2:103052716 IL18RAP 0.29 8.35 0.31 4.31e-16 Asthma; BRCA cis rs7903847 0.642 rs10882909 chr10:99137998 G/C cg08345082 chr10:99160200 RRP12 -0.29 -8.61 -0.32 5.71e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg27170947 chr2:26402098 FAM59B -0.96 -17.33 -0.57 1.94e-55 Gut microbiome composition (summer); BRCA cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg12311346 chr5:56204834 C5orf35 -0.62 -13.08 -0.46 7.94e-35 Initial pursuit acceleration; BRCA cis rs4363385 0.679 rs6686285 chr1:152984561 T/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.4 -0.32 2.89e-16 Inflammatory skin disease; BRCA trans rs7618501 0.633 rs2526748 chr3:50080439 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.32 -8.79 -0.33 1.42e-17 Intelligence (multi-trait analysis); BRCA cis rs72781680 1.000 rs55982282 chr2:24188128 G/A cg20701182 chr2:24300061 SF3B14 0.68 10.09 0.37 2.63e-22 Lymphocyte counts; BRCA cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg11764359 chr7:65958608 NA -0.62 -10.58 -0.39 3.35e-24 Aortic root size; BRCA cis rs2463822 0.858 rs2513037 chr11:62084822 A/T cg06239285 chr11:62104954 ASRGL1 -0.64 -10.77 -0.39 5.46e-25 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg07636037 chr3:49044803 WDR6 0.94 27.29 0.73 2.81e-109 Parkinson's disease; BRCA cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg01448562 chr3:133502909 NA -0.63 -14.57 -0.5 1.02e-41 Iron status biomarkers; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg00677455 chr12:58241039 CTDSP2 -0.35 -7.91 -0.3 1.1e-14 Celiac disease or Rheumatoid arthritis; BRCA trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21659725 chr3:3221576 CRBN 0.5 12.9 0.45 5.2e-34 Intelligence (multi-trait analysis); BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg03354898 chr7:1950403 MAD1L1 -0.47 -9.81 -0.36 3.06e-21 Bipolar disorder and schizophrenia; BRCA cis rs73416724 1.000 rs4714675 chr6:43287893 T/C cg26312998 chr6:43337775 ZNF318 -0.47 -7.81 -0.3 2.32e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs7917772 0.582 rs6584512 chr10:104329685 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.68e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg10729496 chr3:10149963 C3orf24 0.41 7.88 0.3 1.44e-14 Alzheimer's disease; BRCA cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.7 0.36 7.73e-21 Bipolar disorder; BRCA cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg04972856 chr6:88032051 C6orf162;GJB7 0.32 8.46 0.32 1.89e-16 Monocyte percentage of white cells; BRCA cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.666 rs7943140 chr11:973824 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.61 0.55 8.94e-52 Alzheimer's disease (late onset); BRCA cis rs1267303 0.642 rs6696219 chr1:47000408 T/C cg25110126 chr1:46999211 NA 0.57 11.0 0.4 6.62e-26 Monobrow; BRCA cis rs4268898 0.722 rs6723257 chr2:24391129 A/G cg06627628 chr2:24431161 ITSN2 0.42 8.67 0.32 3.51e-17 Asthma; BRCA cis rs6484504 0.532 rs2774403 chr11:31320530 A/T cg26647111 chr11:31128758 NA 0.4 9.15 0.34 7.36e-19 Red blood cell count; BRCA trans rs9944715 1.000 rs4890634 chr18:43854259 C/T cg01718231 chr17:29326311 RNF135 -0.45 -8.97 -0.33 3.23e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.82 0.62 1.71e-68 Platelet count; BRCA cis rs11997175 1.000 rs11997175 chr8:33770070 A/G ch.8.33884649F chr8:33765107 NA -0.45 -11.37 -0.41 2.16e-27 Body mass index; BRCA cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg05347473 chr6:146136440 FBXO30 0.39 8.06 0.3 3.81e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg16339924 chr4:17578868 LAP3 -0.57 -13.24 -0.46 1.59e-35 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg23583168 chr7:148888333 NA -0.78 -18.82 -0.6 3.22e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9399135 0.967 rs9321481 chr6:135352648 C/G cg22676075 chr6:135203613 NA -0.38 -7.85 -0.3 1.81e-14 Red blood cell count; BRCA cis rs3772130 0.624 rs56382357 chr3:121452339 T/C cg20356878 chr3:121714668 ILDR1 0.37 8.32 0.31 5.23e-16 Cognitive performance; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.25 0.41 6.58e-27 Platelet count; BRCA cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg05623727 chr3:50126028 RBM5 0.43 10.14 0.37 1.71e-22 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.855 rs12761180 chr10:872086 C/T cg10556349 chr10:835070 NA 0.73 9.85 0.36 2.08e-21 Eosinophil percentage of granulocytes; BRCA cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.82 -0.3 2.21e-14 Electroencephalogram traits; BRCA cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg03213289 chr20:61660250 NA 0.62 16.45 0.55 5.93e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs6429082 0.875 rs4659524 chr1:235583354 C/T cg26050004 chr1:235667680 B3GALNT2 -0.35 -8.39 -0.31 3.16e-16 Adiposity; BRCA cis rs4908768 0.539 rs7526171 chr1:8650185 T/C cg20416874 chr1:8611966 RERE -0.3 -8.28 -0.31 6.99e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2387326 0.672 rs12254264 chr10:129945519 C/T cg16087940 chr10:129947807 NA -0.45 -8.04 -0.3 4.23e-15 Select biomarker traits; BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg19346786 chr7:2764209 NA -0.37 -11.07 -0.4 3.7e-26 Height; BRCA cis rs58799304 0.531 rs74965833 chr1:156054119 C/T cg15685922 chr1:156045208 MEX3A -0.42 -8.21 -0.31 1.26e-15 Ischemic stroke; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg09263875 chr16:632152 PIGQ 0.72 20.67 0.63 4.71e-73 Height; BRCA cis rs2797160 0.967 rs2747718 chr6:126009109 C/A cg05901451 chr6:126070800 HEY2 0.4 9.71 0.36 6.73e-21 Endometrial cancer; BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.4 0.35 9.76e-20 Tonsillectomy; BRCA cis rs2425143 1.000 rs12480408 chr20:34234800 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.0 -0.34 2.49e-18 Blood protein levels; BRCA cis rs9473147 0.516 rs9296561 chr6:47488938 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.93e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg06115741 chr20:33292138 TP53INP2 0.38 8.61 0.32 5.8e-17 Glomerular filtration rate (creatinine); BRCA cis rs941873 0.868 rs7898 chr10:81114959 C/T cg09469691 chr10:81107165 PPIF 0.44 9.71 0.36 6.73e-21 Height; BRCA cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg08975724 chr8:8085496 FLJ10661 -0.44 -8.63 -0.32 4.71e-17 Myopia (pathological); BRCA cis rs9986765 1.000 rs73452567 chr7:142816043 T/G cg22531018 chr7:142981779 TMEM139 0.66 10.39 0.38 1.75e-23 Cancer;Dermatomyositis; BRCA cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.55 -0.32 9.4e-17 Monocyte percentage of white cells; BRCA cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg01475377 chr6:109611718 NA -0.59 -16.52 -0.55 2.62e-51 Reticulocyte fraction of red cells; BRCA cis rs67981189 0.789 rs2810073 chr14:71383848 A/G cg15816911 chr14:71606274 NA -0.36 -7.94 -0.3 9.44e-15 Schizophrenia; BRCA cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg08917208 chr2:24149416 ATAD2B 0.92 13.59 0.47 3.74e-37 Lymphocyte counts; BRCA cis rs17784882 0.524 rs7433300 chr3:47120640 G/A cg27129171 chr3:47204927 SETD2 0.66 15.39 0.52 1.13e-45 QT interval; BRCA cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs2404602 0.647 rs12904149 chr15:77043652 A/C cg23625390 chr15:77176239 SCAPER -0.55 -12.83 -0.45 1.1e-33 Blood metabolite levels; BRCA cis rs769267 0.598 rs8108705 chr19:19675367 G/T cg03709012 chr19:19516395 GATAD2A -0.5 -9.91 -0.36 1.26e-21 Tonsillectomy; BRCA cis rs295137 0.836 rs1217456 chr2:201092279 C/T cg23649088 chr2:200775458 C2orf69 0.43 9.31 0.35 1.95e-19 Asthma (bronchodilator response); BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg00106254 chr7:1943704 MAD1L1 -0.3 -8.15 -0.31 1.94e-15 Bipolar disorder and schizophrenia; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.63 -13.35 -0.47 4.92e-36 Lymphocyte counts; BRCA cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg03146154 chr1:46216737 IPP -0.44 -9.85 -0.36 2.04e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg24812749 chr6:127587940 RNF146 0.87 19.95 0.62 3.44e-69 Breast cancer; BRCA cis rs9457247 0.602 rs9457262 chr6:167473685 A/G cg07741184 chr6:167504864 NA 0.36 10.5 0.38 6.63e-24 Crohn's disease; BRCA trans rs4332037 0.624 rs56256289 chr7:1892529 C/T cg11693508 chr17:37793320 STARD3 0.6 11.34 0.41 2.73e-27 Bipolar disorder; BRCA cis rs2354432 0.607 rs7537279 chr1:146673642 A/G cg25205988 chr1:146714368 CHD1L 0.84 10.87 0.4 2.19e-25 Mitochondrial DNA levels; BRCA trans rs9858542 1.000 rs13085791 chr3:49721798 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.98 -0.37 7.01e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg18876405 chr7:65276391 NA 0.46 10.29 0.38 4.53e-23 Aortic root size; BRCA trans rs8073060 0.855 rs12150450 chr17:33868896 A/T cg19694781 chr19:47549865 TMEM160 0.56 11.9 0.43 1.22e-29 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs34779708 0.931 rs4934710 chr10:35350416 T/C cg03585969 chr10:35415529 CREM 0.55 11.41 0.41 1.41e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1878931 0.501 rs9302871 chr16:3415512 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 12.03 0.43 3.58e-30 Body mass index (adult); BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.82 -13.69 -0.48 1.34e-37 Platelet count; BRCA cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg18200150 chr17:30822561 MYO1D -0.35 -8.96 -0.33 3.4e-18 Schizophrenia; BRCA cis rs11585357 0.947 rs72646789 chr1:17610030 C/T cg08277548 chr1:17600880 PADI3 -0.74 -12.32 -0.44 2e-31 Hair shape; BRCA cis rs6763687 0.664 rs9841859 chr3:171806523 A/G cg16233210 chr3:171778391 FNDC3B 0.39 9.19 0.34 5.47e-19 Red cell distribution width; BRCA cis rs2070488 0.775 rs6599211 chr3:38558830 A/G cg24069376 chr3:38537580 EXOG -0.34 -9.45 -0.35 6.23e-20 Electrocardiographic conduction measures; BRCA cis rs4423214 0.840 rs1790343 chr11:71177207 T/C cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg03609598 chr5:56110824 MAP3K1 -0.49 -8.2 -0.31 1.31e-15 Initial pursuit acceleration; BRCA cis rs13102973 0.965 rs7656631 chr4:135869921 C/T cg14419869 chr4:135874104 NA -0.59 -12.99 -0.46 2.18e-34 Subjective well-being; BRCA cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg04450456 chr4:17643702 FAM184B 0.33 9.52 0.35 3.37e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17376456 0.569 rs2045019 chr5:93201971 C/T cg25358565 chr5:93447407 FAM172A -0.66 -11.32 -0.41 3.21e-27 Diabetic retinopathy; BRCA cis rs11758351 1.000 rs80095925 chr6:26184942 C/T cg01420254 chr6:26195488 NA 0.57 7.89 0.3 1.3e-14 Gout;Renal underexcretion gout; BRCA cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs9310732 0.657 rs9310730 chr3:24215414 C/G cg15359321 chr3:24203479 THRB 0.41 10.02 0.37 4.93e-22 Schizophrenia; BRCA cis rs853679 0.546 rs200953 chr6:27837267 T/C cg26587870 chr6:27730563 NA -0.53 -8.14 -0.31 2.06e-15 Depression; BRCA cis rs7666738 0.791 rs10022061 chr4:98926821 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg15556689 chr8:8085844 FLJ10661 0.41 11.66 0.42 1.28e-28 Mood instability; BRCA cis rs7560272 0.529 rs2421672 chr2:73955540 G/A cg20560298 chr2:73613845 ALMS1 0.33 8.61 0.32 5.87e-17 Schizophrenia; BRCA cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.29 0.31 6.67e-16 Breast cancer; BRCA cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.19e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.6e-52 Bone mineral density; BRCA cis rs7737355 1.000 rs7737355 chr5:130604811 T/A cg06307176 chr5:131281290 NA 0.47 9.22 0.34 4.3e-19 Life satisfaction; BRCA cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg00990874 chr7:1149470 C7orf50 -0.52 -9.49 -0.35 4.61e-20 Bronchopulmonary dysplasia; BRCA cis rs9457247 0.561 rs916331 chr6:167470559 T/G cg07741184 chr6:167504864 NA 0.36 10.52 0.38 5.61e-24 Crohn's disease; BRCA cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg23505145 chr19:12996616 KLF1 0.55 12.62 0.45 9.42e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.509 rs556468 chr2:219355794 G/A cg10223061 chr2:219282414 VIL1 -0.27 -7.92 -0.3 1.04e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs870825 0.616 rs4416519 chr4:185639502 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA trans rs1493916 0.905 rs4239383 chr18:31401066 T/C cg27147174 chr7:100797783 AP1S1 -0.56 -10.93 -0.4 1.28e-25 Life satisfaction; BRCA cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -10.2 -0.37 9.69e-23 Autism spectrum disorder or schizophrenia; BRCA cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg21573476 chr21:45109991 RRP1B 0.43 10.14 0.37 1.73e-22 Mean corpuscular volume; BRCA cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg19077165 chr18:44547161 KATNAL2 -0.54 -11.63 -0.42 1.75e-28 Personality dimensions; BRCA cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg08885076 chr2:99613938 TSGA10 -0.52 -11.8 -0.42 3.27e-29 Chronic sinus infection; BRCA cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.66 14.9 0.51 2.47e-43 Breast cancer; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg23978390 chr7:1156363 C7orf50 0.42 9.49 0.35 4.53e-20 Longevity;Endometriosis; BRCA cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.59 12.18 0.43 7.69e-31 Tonsillectomy; BRCA cis rs832540 0.519 rs1445998 chr5:56268205 A/G cg18230493 chr5:56204884 C5orf35 -0.41 -8.21 -0.31 1.26e-15 Coronary artery disease; BRCA trans rs2204008 0.627 rs1851117 chr12:38398987 G/T cg06521331 chr12:34319734 NA -0.47 -8.5 -0.32 1.29e-16 Bladder cancer; BRCA cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg09877947 chr5:131593287 PDLIM4 0.36 7.88 0.3 1.46e-14 Breast cancer; BRCA cis rs9788682 0.747 rs2938674 chr15:78757913 C/A cg24631222 chr15:78858424 CHRNA5 0.47 9.3 0.35 2.11e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.45e-19 Bipolar disorder; BRCA cis rs17253792 0.822 rs9972178 chr14:56073480 A/G cg01858014 chr14:56050164 KTN1 -0.78 -10.82 -0.39 3.74e-25 Putamen volume; BRCA cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg02475777 chr4:1388615 CRIPAK 0.36 7.92 0.3 1.07e-14 Longevity; BRCA cis rs7246657 0.524 rs10411251 chr19:37428755 C/T cg23950597 chr19:37808831 NA -0.51 -8.29 -0.31 6.94e-16 Coronary artery calcification; BRCA cis rs11250464 1.000 rs11250464 chr10:1406364 A/G cg08668359 chr10:1443807 ADARB2 0.47 9.26 0.34 3.06e-19 Radiation response; BRCA cis rs9443645 0.901 rs9343856 chr6:79678211 G/A cg11833968 chr6:79620685 NA -0.45 -9.92 -0.37 1.18e-21 Intelligence (multi-trait analysis); BRCA trans rs12310956 0.532 rs10844712 chr12:33961022 G/A cg26384229 chr12:38710491 ALG10B 0.52 11.18 0.4 1.26e-26 Morning vs. evening chronotype; BRCA cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg12591125 chr7:1885375 MAD1L1 0.51 8.92 0.33 4.87e-18 Bipolar disorder; BRCA cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg17971929 chr21:40555470 PSMG1 0.53 11.28 0.41 4.71e-27 Cognitive function; BRCA cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg02544614 chr20:61657117 NA 0.29 8.12 0.31 2.5e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7647973 0.587 rs10452032 chr3:49680973 G/A cg07636037 chr3:49044803 WDR6 0.52 8.46 0.32 1.81e-16 Menarche (age at onset); BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg22907277 chr7:1156413 C7orf50 0.61 12.03 0.43 3.51e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.24e-23 Motion sickness; BRCA cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.2 0.43 6.14e-31 Lung cancer in ever smokers; BRCA trans rs5756813 0.754 rs762982 chr22:38144235 A/G cg19894588 chr14:64061835 NA 0.46 9.72 0.36 6.23e-21 Optic cup area;Vertical cup-disc ratio; BRCA cis rs7103648 0.569 rs11039266 chr11:47532395 T/G cg03711944 chr11:47377212 SPI1 -0.44 -10.29 -0.38 4.51e-23 Diastolic blood pressure;Systolic blood pressure; BRCA trans rs11098499 0.874 rs13123591 chr4:120105990 T/G cg25214090 chr10:38739885 LOC399744 0.51 10.51 0.38 5.99e-24 Corneal astigmatism; BRCA cis rs1020064 0.609 rs2576748 chr2:105911258 A/C cg02079111 chr2:105885981 TGFBRAP1 -0.42 -8.24 -0.31 9.73e-16 AIDS; BRCA cis rs12477438 0.798 rs4850891 chr2:99574642 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.66 -0.57 3.68e-57 Chronic sinus infection; BRCA cis rs11585357 0.501 rs17458091 chr1:17595925 A/G cg08277548 chr1:17600880 PADI3 -0.52 -8.32 -0.31 5.21e-16 Hair shape; BRCA cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg18867708 chr6:26865862 GUSBL1 -0.4 -7.85 -0.3 1.76e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs2742417 0.603 rs2673062 chr3:45763635 A/G cg04837898 chr3:45731254 SACM1L -0.39 -7.98 -0.3 6.71e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs6582630 0.502 rs11614397 chr12:38328163 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.33 0.38 3.05e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs7552404 0.924 rs114752222 chr1:76180878 C/T cg03433033 chr1:76189801 ACADM 0.86 22.27 0.66 8.81e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg07262247 chr5:131593730 PDLIM4 0.36 8.58 0.32 7.25e-17 Acylcarnitine levels; BRCA cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.5e-64 Cognitive function; BRCA cis rs9399135 1.000 rs4475342 chr6:135283348 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.21 0.43 5.8e-31 Red blood cell count; BRCA cis rs3008870 1.000 rs975451 chr1:67480060 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.95 21.16 0.64 9.69e-76 Lymphocyte percentage of white cells; BRCA cis rs8141529 0.636 rs5762799 chr22:29187380 G/T cg15103426 chr22:29168792 CCDC117 0.47 9.14 0.34 8.32e-19 Lymphocyte counts; BRCA cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg18196295 chr10:418757 DIP2C -0.46 -9.43 -0.35 7.66e-20 Psychosis in Alzheimer's disease; BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg00166722 chr3:10149974 C3orf24 0.56 11.16 0.4 1.5e-26 Alzheimer's disease; BRCA cis rs600806 0.850 rs10858091 chr1:109935578 T/C cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs2832191 1.000 rs9984793 chr21:30486471 T/C cg24692254 chr21:30365293 RNF160 -0.59 -15.06 -0.51 4.24e-44 Dental caries; BRCA cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg16230307 chr14:35515116 FAM177A1 0.77 15.53 0.52 2.2e-46 Psoriasis; BRCA trans rs6479901 0.512 rs6415875 chr10:64986417 A/G cg14819942 chr15:35414228 NA -0.35 -8.65 -0.32 4.26e-17 Intelligence (multi-trait analysis); BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.24 -0.34 3.69e-19 Total body bone mineral density; BRCA cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg08807101 chr21:30365312 RNF160 0.38 8.23 0.31 1.03e-15 Pancreatic cancer; BRCA cis rs2303759 0.666 rs66967196 chr19:49808894 G/A cg24324837 chr19:49891574 CCDC155 0.47 7.91 0.3 1.16e-14 Multiple sclerosis; BRCA cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg10802521 chr3:52805072 NEK4 -0.33 -8.68 -0.32 3.36e-17 Bipolar disorder; BRCA cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg13256891 chr4:100009986 ADH5 -0.55 -10.07 -0.37 3.09e-22 Smoking initiation; BRCA cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg22875332 chr1:76189707 ACADM 0.64 11.68 0.42 1.08e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7264396 0.511 rs2425102 chr20:34312303 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -12.02 -0.43 3.96e-30 Total cholesterol levels; BRCA cis rs3760982 0.585 rs67773424 chr19:44293994 G/A cg12072164 chr19:44306565 LYPD5 0.36 8.55 0.32 8.85e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs8038465 0.592 rs1542579 chr15:73935897 A/G cg15420318 chr15:73925796 NPTN 0.42 9.33 0.35 1.65e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6570726 0.935 rs419850 chr6:145827281 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.77 0.5 1.09e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg13271783 chr10:134563150 INPP5A -0.47 -9.89 -0.36 1.46e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg05535760 chr7:792225 HEATR2 -0.72 -11.64 -0.42 1.59e-28 Cerebrospinal P-tau181p levels; BRCA trans rs629535 0.767 rs62513418 chr8:70114376 G/T cg21567404 chr3:27674614 NA -0.96 -20.34 -0.63 2.85e-71 Dupuytren's disease; BRCA cis rs514406 0.644 rs928451 chr1:53195800 A/G cg24675658 chr1:53192096 ZYG11B 0.68 14.68 0.5 2.81e-42 Monocyte count; BRCA cis rs6570726 0.791 rs9399558 chr6:145911730 T/C cg23711669 chr6:146136114 FBXO30 0.79 18.95 0.6 6.68e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg17158414 chr2:27665306 KRTCAP3 -0.35 -8.96 -0.33 3.59e-18 Total body bone mineral density; BRCA cis rs67981189 0.593 rs9806042 chr14:71530993 G/C cg15816911 chr14:71606274 NA 0.38 8.55 0.32 9.13e-17 Schizophrenia; BRCA cis rs72781680 0.898 rs17462433 chr2:24012758 T/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg11764359 chr7:65958608 NA -0.68 -15.16 -0.51 1.37e-44 Aortic root size; BRCA trans rs8002861 0.619 rs9567289 chr13:44437104 C/T cg17145862 chr1:211918768 LPGAT1 0.47 10.77 0.39 5.47e-25 Leprosy; BRCA cis rs478304 0.903 rs495961 chr11:65540886 C/T cg08755490 chr11:65554678 OVOL1 0.53 10.95 0.4 1.12e-25 Acne (severe); BRCA cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.32 -0.35 1.84e-19 Bipolar disorder; BRCA cis rs10791097 0.702 rs10894267 chr11:130714861 C/T cg12179176 chr11:130786555 SNX19 -0.5 -10.76 -0.39 6e-25 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs9814567 1.000 rs1357762 chr3:134264859 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.11 -0.34 1.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs460214 0.553 rs9976546 chr21:40028193 C/G cg21578987 chr21:40029669 ERG 0.35 8.28 0.31 7.12e-16 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.31 8.11 0.31 2.67e-15 Monocyte percentage of white cells; BRCA cis rs13102973 0.640 rs11099303 chr4:135887709 C/A cg14419869 chr4:135874104 NA -0.5 -9.79 -0.36 3.37e-21 Subjective well-being; BRCA cis rs6835098 0.924 rs13125240 chr4:174151619 T/C cg27433088 chr4:174089019 GALNT7 -0.33 -8.27 -0.31 7.84e-16 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs12200560 0.505 rs211176 chr6:97073821 G/A cg06623918 chr6:96969491 KIAA0776 0.53 12.8 0.45 1.43e-33 Coronary heart disease; BRCA cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -15.04 -0.51 5.54e-44 Chronic sinus infection; BRCA cis rs8038465 0.615 rs6495075 chr15:73981005 A/G cg15420318 chr15:73925796 NPTN 0.38 8.51 0.32 1.26e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7904368 0.951 rs7905776 chr10:16853609 C/T cg14835575 chr10:16859367 RSU1 0.5 11.59 0.42 2.43e-28 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7731783 1 rs7731783 chr5:177060312 T/C cg10940203 chr5:177434438 FAM153C 0.42 10.84 0.39 3e-25 Methadone dose in opioid dependence; BRCA cis rs929596 0.574 rs75444879 chr2:234587848 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.36 -9.1 -0.34 1.18e-18 Total bilirubin levels in HIV-1 infection; BRCA cis rs7945705 0.902 rs10769979 chr11:9010659 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.6 13.12 0.46 5.34e-35 Hemoglobin concentration; BRCA cis rs344364 0.511 rs2982452 chr16:1949511 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg10253484 chr15:75165896 SCAMP2 -0.51 -9.86 -0.36 1.99e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs16958440 0.867 rs16949157 chr18:44691324 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs7593730 1.000 rs2966379 chr2:161123251 C/T cg22609984 chr2:161126801 NA 0.4 8.01 0.3 5.57e-15 Type 2 diabetes; BRCA cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg20701182 chr2:24300061 SF3B14 0.68 12.9 0.45 5.2e-34 Lymphocyte counts; BRCA cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg15664640 chr17:80829946 TBCD -0.32 -8.11 -0.31 2.56e-15 Breast cancer; BRCA cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg18357526 chr6:26021779 HIST1H4A 0.46 8.24 0.31 9.47e-16 Intelligence (multi-trait analysis); BRCA cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg08822215 chr16:89438651 ANKRD11 -0.42 -8.16 -0.31 1.76e-15 Multiple myeloma (IgH translocation); BRCA cis rs6120849 0.754 rs3746435 chr20:33587198 G/C cg24642439 chr20:33292090 TP53INP2 0.6 10.35 0.38 2.61e-23 Protein C levels; BRCA cis rs2625529 0.627 rs12902661 chr15:72480158 T/G cg16672083 chr15:72433130 SENP8 -0.82 -17.32 -0.57 2.27e-55 Red blood cell count; BRCA trans rs61931739 0.635 rs1852225 chr12:33963004 C/T cg26384229 chr12:38710491 ALG10B 0.39 8.87 0.33 7e-18 Morning vs. evening chronotype; BRCA cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.15 -0.34 7.47e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2882667 0.728 rs10068766 chr5:138276784 G/A cg04439458 chr5:138467593 SIL1 -0.32 -8.14 -0.31 2.04e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1215050 0.791 rs165239 chr4:98682549 C/T cg05340658 chr4:99064831 C4orf37 0.45 10.23 0.38 7.67e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg10057126 chr4:77819792 ANKRD56 0.68 15.42 0.52 7.78e-46 Emphysema distribution in smoking; BRCA cis rs11779988 0.545 rs427168 chr8:17784829 G/A cg01800426 chr8:17659068 MTUS1 -0.4 -8.4 -0.32 2.97e-16 Breast cancer; BRCA cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.17 -0.37 1.29e-22 Body mass index; BRCA cis rs6570726 0.935 rs906774 chr6:145813770 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.19 0.52 1.03e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg24101359 chr6:42928495 GNMT -0.53 -9.96 -0.37 8.3e-22 Blood protein levels; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.52 -0.35 3.54e-20 Total body bone mineral density; BRCA cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.9 0.36 1.36e-21 Bipolar disorder; BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg09263875 chr16:632152 PIGQ 0.72 20.62 0.63 8.06e-73 Height; BRCA cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg02466173 chr16:30829666 NA -0.53 -11.6 -0.42 2.25e-28 Multiple myeloma; BRCA cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg04450456 chr4:17643702 FAM184B -0.37 -10.65 -0.39 1.69e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7727544 0.735 rs274558 chr5:131721174 A/G cg24060327 chr5:131705240 SLC22A5 0.51 10.66 0.39 1.51e-24 Blood metabolite levels; BRCA cis rs6904897 0.563 rs6569976 chr6:135224753 A/C cg22676075 chr6:135203613 NA 0.61 13.18 0.46 2.93e-35 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg13010199 chr12:38710504 ALG10B 0.44 9.21 0.34 4.78e-19 Morning vs. evening chronotype; BRCA cis rs9287719 0.967 rs7566875 chr2:10754792 T/C cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs1580019 0.563 rs10486509 chr7:32585443 C/G cg14728415 chr7:32535168 LSM5;AVL9 -0.37 -8.12 -0.31 2.42e-15 Cognitive ability; BRCA cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg13902645 chr11:5959945 NA 0.58 13.54 0.47 6.56e-37 DNA methylation (variation); BRCA cis rs5167 0.504 rs10426750 chr19:45457684 G/C cg09555818 chr19:45449301 APOC2 0.46 12.07 0.43 2.2e-30 Blood protein levels; BRCA cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg04756594 chr16:24857601 SLC5A11 0.46 9.47 0.35 5.24e-20 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.71 -0.61 6.44e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11764590 0.724 rs62444917 chr7:2107262 A/C cg11693508 chr17:37793320 STARD3 0.38 7.99 0.3 6.21e-15 Neuroticism; BRCA cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg05283184 chr6:79620031 NA -0.44 -11.41 -0.41 1.44e-27 Intelligence (multi-trait analysis); BRCA cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg25174290 chr11:3078921 CARS 0.45 13.83 0.48 3.15e-38 Longevity; BRCA cis rs6545883 0.929 rs1900572 chr2:61650715 T/G cg15711740 chr2:61764176 XPO1 0.54 13.6 0.47 3.52e-37 Tuberculosis; BRCA cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg26384229 chr12:38710491 ALG10B 0.71 16.86 0.55 4.84e-53 Drug-induced liver injury (flucloxacillin); BRCA cis rs735396 0.595 rs2258287 chr12:121454313 G/T cg25281562 chr12:121454272 C12orf43 0.36 9.42 0.35 8.34e-20 N-glycan levels; BRCA cis rs2997447 0.688 rs3008431 chr1:26371281 A/G cg19633962 chr1:26362018 EXTL1 -0.59 -10.48 -0.38 8.19e-24 QRS complex (12-leadsum); BRCA trans rs6582630 0.537 rs35336822 chr12:38346251 T/C cg06521331 chr12:34319734 NA -0.45 -8.36 -0.31 3.83e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg01028140 chr2:1542097 TPO -0.65 -13.29 -0.47 9.44e-36 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6912958 0.754 rs4707374 chr6:88255438 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.8e-16 Monocyte percentage of white cells; BRCA cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg02297831 chr4:17616191 MED28 0.34 7.82 0.3 2.19e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9814567 0.762 rs13071253 chr3:134316653 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.57 14.25 0.49 3.14e-40 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.11 -0.46 5.75e-35 Platelet count; BRCA trans rs11098499 0.691 rs9996494 chr4:120238880 C/A cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.36e-23 Corneal astigmatism; BRCA cis rs10870270 0.956 rs4880405 chr10:133787021 G/A cg17892150 chr10:133769511 PPP2R2D -0.7 -13.92 -0.48 1.21e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2439831 0.850 rs28707214 chr15:44131623 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.75 0.45 2.5e-33 Lung cancer in ever smokers; BRCA cis rs1707322 0.963 rs4459051 chr1:46451203 A/G cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg27631724 chr1:11040367 C1orf127 0.3 7.81 0.3 2.32e-14 Ewing sarcoma; BRCA cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg08392591 chr16:89556376 ANKRD11 0.39 9.07 0.34 1.46e-18 Multiple myeloma (IgH translocation); BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg05863683 chr7:1912471 MAD1L1 0.37 8.37 0.31 3.72e-16 Bipolar disorder and schizophrenia; BRCA cis rs6763687 0.637 rs12696328 chr3:171814645 C/G cg16233210 chr3:171778391 FNDC3B 0.39 9.19 0.34 5.42e-19 Red cell distribution width; BRCA cis rs921968 0.565 rs11896209 chr2:219599268 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.22 -0.41 8.62e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.5e-36 High light scatter reticulocyte count; BRCA cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -8.16 -0.31 1.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 0.930 rs928813 chr3:38528537 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.15 0.62 2.7e-70 Electrocardiographic conduction measures; BRCA cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg07493874 chr5:1342172 CLPTM1L 0.45 12.5 0.44 3.09e-32 Lung cancer; BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -11.04 -0.4 4.65e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9462027 0.628 rs6942040 chr6:34761809 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA cis rs35110281 0.627 rs1436291 chr21:44965485 T/C cg01579765 chr21:45077557 HSF2BP -0.34 -8.87 -0.33 7.01e-18 Mean corpuscular volume; BRCA cis rs13256369 0.851 rs12541477 chr8:8563895 G/A cg18904891 chr8:8559673 CLDN23 0.65 12.91 0.45 4.83e-34 Obesity-related traits; BRCA cis rs6570726 0.902 rs396681 chr6:145853603 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.09 0.51 3.23e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg00814883 chr7:100076585 TSC22D4 -0.49 -9.62 -0.36 1.5e-20 Platelet count; BRCA cis rs7572263 0.959 rs12995271 chr2:209048136 T/C cg23998903 chr2:209048830 C2orf80 -0.32 -8.13 -0.31 2.19e-15 Glioma;Non-glioblastoma glioma; BRCA cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg05347473 chr6:146136440 FBXO30 0.54 10.31 0.38 3.66e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -14.71 -0.5 2.11e-42 Personality dimensions; BRCA cis rs7592578 0.664 rs10931461 chr2:191405280 T/A cg11845111 chr2:191398756 TMEM194B 0.8 15.28 0.52 3.68e-45 Diastolic blood pressure; BRCA cis rs312274 0.515 rs56294359 chr12:41311120 T/C cg17827154 chr12:41323612 CNTN1 -0.43 -10.59 -0.39 2.93e-24 Metabolite levels (X-11787); BRCA cis rs796364 1.000 rs796364 chr2:200716119 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.66 11.17 0.4 1.36e-26 Schizophrenia; BRCA cis rs12474201 0.832 rs11695058 chr2:46978349 A/G cg06386533 chr2:46925753 SOCS5 0.83 17.61 0.57 7.05e-57 Height; BRCA cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg00684032 chr4:1343700 KIAA1530 0.53 12.35 0.44 1.47e-31 Obesity-related traits; BRCA trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21582582 chr3:182698605 DCUN1D1 0.39 10.16 0.37 1.38e-22 Intelligence (multi-trait analysis); BRCA cis rs13095912 1.000 rs36066570 chr3:185314454 C/A cg11274856 chr3:185301563 NA 0.34 8.53 0.32 1.1e-16 Systolic blood pressure; BRCA cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.21e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9287719 0.934 rs4371336 chr2:10755723 C/A cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs60871478 1.000 rs9195 chr7:825786 C/T cg04727924 chr7:799746 HEATR2 0.56 11.14 0.4 1.85e-26 Cerebrospinal P-tau181p levels; BRCA cis rs9815354 0.812 rs17217536 chr3:41923300 A/C cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg09177884 chr7:1199841 ZFAND2A -0.64 -16.73 -0.55 2.16e-52 Longevity;Endometriosis; BRCA cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.0 0.34 2.65e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.5 0.35 4e-20 Menopause (age at onset); BRCA cis rs752010 0.619 rs1123483 chr1:42114198 C/T cg06885757 chr1:42089581 HIVEP3 -0.33 -10.78 -0.39 5.23e-25 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg06808227 chr14:105710500 BRF1 -0.79 -16.07 -0.54 4.74e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs514406 0.584 rs12095247 chr1:53193796 A/C cg08859206 chr1:53392774 SCP2 0.4 7.86 0.3 1.69e-14 Monocyte count; BRCA cis rs12497850 0.863 rs4858799 chr3:48728204 G/A cg00383909 chr3:49044727 WDR6 0.59 10.59 0.39 2.88e-24 Parkinson's disease; BRCA cis rs8177179 0.565 rs4355280 chr3:133468425 A/G cg01448562 chr3:133502909 NA -0.4 -9.25 -0.34 3.22e-19 Iron status biomarkers (transferrin levels); BRCA cis rs739496 0.542 rs7300400 chr12:111792179 A/C cg10833066 chr12:111807467 FAM109A 0.35 8.1 0.31 2.77e-15 Platelet count; BRCA cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg02951883 chr7:2050386 MAD1L1 -0.51 -11.36 -0.41 2.35e-27 Bipolar disorder and schizophrenia; BRCA cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.35e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 7.95e-37 Developmental language disorder (linguistic errors); BRCA cis rs72627509 0.904 rs17081935 chr4:57823476 C/T cg26694713 chr4:57773883 REST 0.46 8.34 0.31 4.45e-16 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg07606381 chr6:8435919 SLC35B3 0.66 14.7 0.5 2.41e-42 Motion sickness; BRCA cis rs7809950 0.678 rs62483640 chr7:106900214 T/G cg23024343 chr7:107201750 COG5 -0.45 -8.8 -0.33 1.28e-17 Coronary artery disease; BRCA cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg06060754 chr5:176797920 RGS14 -0.67 -10.25 -0.38 6.05e-23 Urate levels in lean individuals; BRCA cis rs2073300 1.000 rs6132621 chr20:23442180 C/T cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10751667 1.000 rs6597972 chr11:928402 C/T ch.11.42038R chr11:967971 AP2A2 0.57 18.52 0.59 1.28e-61 Alzheimer's disease (late onset); BRCA trans rs2204008 0.837 rs12369089 chr12:38060263 G/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.47e-21 Bladder cancer; BRCA cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg06808227 chr14:105710500 BRF1 -0.79 -16.08 -0.54 4.34e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg17507749 chr15:85114479 UBE2QP1 0.55 10.43 0.38 1.24e-23 Schizophrenia; BRCA cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs4594175 0.926 rs4243570 chr14:51624243 C/T cg23942311 chr14:51606299 NA 0.33 8.31 0.31 5.55e-16 Cancer; BRCA cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg15017067 chr4:17643749 FAM184B 0.32 9.84 0.36 2.29e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg08508325 chr11:3079039 CARS -0.41 -14.67 -0.5 3.45e-42 Longevity; BRCA cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg20933634 chr6:27740509 NA 0.49 9.71 0.36 6.8e-21 Parkinson's disease; BRCA cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg03264133 chr6:25882463 NA -0.44 -10.18 -0.37 1.14e-22 Blood metabolite levels; BRCA cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg02880119 chr16:3481970 NA -0.42 -7.89 -0.3 1.31e-14 Body mass index (adult); BRCA cis rs796364 0.951 rs769952 chr2:200734368 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.76 12.77 0.45 2.1e-33 Schizophrenia; BRCA trans rs1974653 0.781 rs9605062 chr22:20089880 T/C cg20152630 chr19:46405944 MYPOP 0.38 8.48 0.32 1.61e-16 Schizophrenia; BRCA cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg22903471 chr2:27725779 GCKR -0.36 -8.7 -0.33 2.82e-17 Total body bone mineral density; BRCA cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg12292205 chr6:26970375 C6orf41 -0.8 -19.63 -0.61 1.68e-67 Autism spectrum disorder or schizophrenia; BRCA cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg06618935 chr21:46677482 NA -0.36 -8.09 -0.3 3.1e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6484504 0.576 rs208067 chr11:31153578 C/T cg26647111 chr11:31128758 NA -0.43 -9.25 -0.34 3.43e-19 Red blood cell count; BRCA cis rs9287719 0.624 rs10199635 chr2:10726640 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -8.24 -0.31 1e-15 Developmental language disorder (linguistic errors); BRCA cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.9e-19 Lymphocyte counts; BRCA cis rs7246657 0.943 rs8111782 chr19:37867904 A/G cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs7772486 0.720 rs6931553 chr6:146112348 T/C cg23711669 chr6:146136114 FBXO30 -0.83 -20.4 -0.63 1.31e-71 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00149659 chr3:10157352 C3orf10 0.77 13.26 0.46 1.31e-35 Alzheimer's disease; BRCA cis rs3806843 1.000 rs10037757 chr5:140197222 G/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -9.28 -0.34 2.64e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs9858542 0.537 rs34514189 chr3:49373045 A/G cg00383909 chr3:49044727 WDR6 0.5 9.76 0.36 4.62e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7646881 1.000 rs73015651 chr3:158450922 C/T cg19483011 chr3:158453295 NA -0.48 -8.94 -0.33 4.17e-18 Tetralogy of Fallot; BRCA cis rs896854 0.738 rs481887 chr8:95967838 A/G cg13393036 chr8:95962371 TP53INP1 0.35 8.46 0.32 1.85e-16 Type 2 diabetes; BRCA cis rs11098499 1.000 rs3749591 chr4:120214030 T/G cg09307838 chr4:120376055 NA 0.62 11.62 0.42 1.92e-28 Corneal astigmatism; BRCA cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg27129171 chr3:47204927 SETD2 -0.71 -16.99 -0.56 1.08e-53 Colorectal cancer; BRCA trans rs79976124 0.837 rs11751145 chr6:66642039 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.62 11.7 0.42 8.7e-29 Type 2 diabetes; BRCA cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg04025307 chr7:1156635 C7orf50 0.47 8.96 0.33 3.46e-18 Bronchopulmonary dysplasia; BRCA trans rs61931739 0.534 rs10844774 chr12:34166764 C/T cg26384229 chr12:38710491 ALG10B 0.69 14.65 0.5 4.31e-42 Morning vs. evening chronotype; BRCA cis rs7959452 0.590 rs11177644 chr12:69785748 A/G cg20891283 chr12:69753455 YEATS4 0.71 20.98 0.64 9.04e-75 Blood protein levels; BRCA cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg07636037 chr3:49044803 WDR6 0.56 9.16 0.34 7.19e-19 Menarche (age at onset); BRCA cis rs7772486 0.655 rs2142981 chr6:146071695 G/C cg05347473 chr6:146136440 FBXO30 -0.44 -8.81 -0.33 1.17e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg03188948 chr7:1209495 NA 0.87 11.85 0.42 2.11e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg22535103 chr8:58192502 C8orf71 -0.51 -8.75 -0.33 1.85e-17 Developmental language disorder (linguistic errors); BRCA trans rs6582630 0.519 rs11181998 chr12:38439970 C/A cg06521331 chr12:34319734 NA -0.46 -8.53 -0.32 1.08e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 11.29 0.41 4.65e-27 Alzheimer's disease; BRCA cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg15352829 chr14:105391018 PLD4 -0.38 -12.3 -0.44 2.45e-31 Rheumatoid arthritis; BRCA cis rs10464366 0.957 rs12667577 chr7:39095133 T/G cg15212455 chr7:39170539 POU6F2 0.36 7.88 0.3 1.45e-14 IgG glycosylation; BRCA cis rs6500602 0.964 rs62039173 chr16:4463846 G/A cg08645402 chr16:4508243 NA 0.38 9.05 0.34 1.72e-18 Schizophrenia; BRCA cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg24112000 chr20:60950667 NA -0.59 -12.76 -0.45 2.21e-33 Colorectal cancer; BRCA cis rs9462027 0.628 rs2814959 chr6:34705947 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA cis rs6598955 0.543 rs881578 chr1:26536141 G/A cg12744634 chr1:26560303 CCDC21 0.33 8.96 0.33 3.59e-18 Obesity-related traits; BRCA cis rs9487051 0.839 rs13196590 chr6:109561918 T/C cg21918786 chr6:109611834 NA -0.36 -9.02 -0.34 2.23e-18 Reticulocyte fraction of red cells; BRCA cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg08999081 chr20:33150536 PIGU 0.48 13.2 0.46 2.33e-35 Coronary artery disease; BRCA cis rs250677 0.522 rs6872701 chr5:148359086 C/G cg18129178 chr5:148520854 ABLIM3 0.54 10.41 0.38 1.48e-23 Breast cancer; BRCA cis rs9309473 1.000 rs62151652 chr2:73700131 A/C cg20560298 chr2:73613845 ALMS1 -0.44 -10.65 -0.39 1.67e-24 Metabolite levels; BRCA cis rs1707322 1.000 rs785467 chr1:46521559 A/T cg06784218 chr1:46089804 CCDC17 -0.48 -11.42 -0.41 1.29e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg27398817 chr8:82754497 SNX16 -0.43 -8.53 -0.32 1.04e-16 Diastolic blood pressure; BRCA cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.54 0.42 3.99e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6456156 0.586 rs12525855 chr6:167480013 T/G cg07741184 chr6:167504864 NA 0.34 9.97 0.37 7.51e-22 Primary biliary cholangitis; BRCA cis rs6087990 0.584 rs6058897 chr20:31398105 G/T cg13636640 chr20:31349939 DNMT3B -0.49 -12.32 -0.44 1.85e-31 Ulcerative colitis; BRCA cis rs600231 0.708 rs2957269 chr11:65243007 C/G cg01292856 chr11:65242576 NA 0.33 8.2 0.31 1.36e-15 Bone mineral density; BRCA cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg26647111 chr11:31128758 NA -0.44 -9.5 -0.35 4.05e-20 Red blood cell count; BRCA cis rs490234 0.702 rs12553882 chr9:128195044 G/A cg14078157 chr9:128172775 NA -0.53 -11.28 -0.41 4.71e-27 Mean arterial pressure; BRCA cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14442939 chr10:27389572 ANKRD26 -0.68 -11.41 -0.41 1.35e-27 Breast cancer; BRCA trans rs7615952 0.688 rs12638224 chr3:125541320 C/T cg07211511 chr3:129823064 LOC729375 -0.77 -14.86 -0.51 4.12e-43 Blood pressure (smoking interaction); BRCA cis rs34779708 0.966 rs4934540 chr10:35474699 T/C cg03585969 chr10:35415529 CREM 0.5 10.37 0.38 2.11e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7178424 0.742 rs2414755 chr15:62172429 C/T cg00456672 chr15:62358751 C2CD4A -0.36 -8.73 -0.33 2.14e-17 Height; BRCA cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg18904891 chr8:8559673 CLDN23 0.64 12.86 0.45 8.07e-34 Obesity-related traits; BRCA cis rs4727443 0.866 rs35228488 chr7:99617852 G/C cg22004693 chr7:99632812 ZKSCAN1 0.4 8.98 0.33 2.92e-18 Interstitial lung disease; BRCA cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg12935359 chr14:103987150 CKB 0.63 14.53 0.5 1.58e-41 Intelligence (multi-trait analysis); BRCA cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg18876405 chr7:65276391 NA 0.52 12.1 0.43 1.76e-30 Aortic root size; BRCA trans rs11039798 0.588 rs10838979 chr11:48626810 T/G cg03929089 chr4:120376271 NA 0.49 8.2 0.31 1.36e-15 Axial length; BRCA cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg26850624 chr5:429559 AHRR -0.36 -8.03 -0.3 4.82e-15 Cystic fibrosis severity; BRCA cis rs7264396 0.790 rs6060539 chr20:34239382 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.97 -0.53 1.5e-48 Total cholesterol levels; BRCA cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg09177884 chr7:1199841 ZFAND2A -0.6 -14.57 -0.5 1.02e-41 Longevity;Endometriosis; BRCA cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg12573674 chr2:1569213 NA -0.58 -12.99 -0.46 2.16e-34 IgG glycosylation; BRCA cis rs11098499 0.863 rs1010740 chr4:120463409 C/T cg09307838 chr4:120376055 NA -0.7 -14.01 -0.48 4.22e-39 Corneal astigmatism; BRCA cis rs7772486 0.875 rs7767660 chr6:146436550 T/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.36 -0.31 4.04e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs367943 0.698 rs2217296 chr5:112973829 A/T cg12552261 chr5:112820674 MCC 0.37 7.88 0.3 1.41e-14 Type 2 diabetes; BRCA cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.97 -0.37 7.37e-22 Alzheimer's disease (late onset); BRCA cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg11752832 chr7:134001865 SLC35B4 0.54 13.89 0.48 1.54e-38 Mean platelet volume; BRCA cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.6 0.35 1.83e-20 Menopause (age at onset); BRCA cis rs17401966 0.898 rs12757288 chr1:10323921 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.72 0.48 9.36e-38 Hepatocellular carcinoma; BRCA cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg26116260 chr4:7069785 GRPEL1 0.81 17.7 0.57 2.36e-57 Monocyte percentage of white cells; BRCA cis rs1577917 0.958 rs13213551 chr6:86608701 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.07 -0.43 2.24e-30 Response to antipsychotic treatment; BRCA cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg21475434 chr5:93447410 FAM172A -0.69 -8.88 -0.33 6.49e-18 Diabetic retinopathy; BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs4713118 0.868 rs2893928 chr6:27738430 C/A cg20933634 chr6:27740509 NA 0.45 8.24 0.31 9.74e-16 Parkinson's disease; BRCA cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg17330251 chr7:94953956 PON1 -0.42 -9.0 -0.34 2.53e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs11971779 0.680 rs4728467 chr7:139120562 G/A cg07862535 chr7:139043722 LUC7L2 0.38 10.22 0.37 8.01e-23 Diisocyanate-induced asthma; BRCA cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg12011299 chr4:100065546 ADH4 0.41 10.78 0.39 5.13e-25 Alcohol dependence; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg08470875 chr2:26401718 FAM59B 0.72 11.26 0.41 6.14e-27 Gut microbiome composition (summer); BRCA trans rs35110281 0.565 rs7278003 chr21:44966069 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 10.66 0.39 1.53e-24 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs114722517 chr4:99042061 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.79e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg21535247 chr6:8435926 SLC35B3 0.39 8.83 0.33 9.66e-18 Motion sickness; BRCA cis rs6429082 0.818 rs210037 chr1:235649501 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 13.54 0.47 6.94e-37 Adiposity; BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs495337 1.000 rs11086299 chr20:48548870 G/A cg17835207 chr20:48524531 SPATA2 -0.6 -13.97 -0.48 6.73e-39 Psoriasis; BRCA cis rs12618769 0.652 rs2276603 chr2:99205962 C/T cg10123293 chr2:99228465 UNC50 -0.45 -8.78 -0.33 1.51e-17 Bipolar disorder; BRCA cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -8.2 -0.31 1.36e-15 Personality dimensions; BRCA cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg20203395 chr5:56204925 C5orf35 -0.63 -12.62 -0.45 9.31e-33 Initial pursuit acceleration; BRCA cis rs6901250 0.759 rs9489040 chr6:117131740 G/A cg12892004 chr6:117198278 RFX6 0.37 9.02 0.34 2.15e-18 C-reactive protein levels; BRCA cis rs9858542 0.903 rs11921590 chr3:49644193 T/C cg03060546 chr3:49711283 APEH -0.58 -11.63 -0.42 1.77e-28 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7246967 0.673 rs4933026 chr19:22874492 A/T cg23217946 chr19:22817039 ZNF492 0.46 8.43 0.32 2.38e-16 Bronchopulmonary dysplasia; BRCA cis rs72781680 0.898 rs718139 chr2:23975911 G/A cg20701182 chr2:24300061 SF3B14 0.65 9.34 0.35 1.64e-19 Lymphocyte counts; BRCA cis rs7582720 1.000 rs6725887 chr2:203745885 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.8 -12.27 -0.44 3.17e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs7917772 0.503 rs56219824 chr10:104302337 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10129255 0.500 rs11627315 chr14:107210420 T/C cg07958169 chr14:107095056 NA -0.37 -8.11 -0.31 2.62e-15 Kawasaki disease; BRCA cis rs2625529 0.503 rs7162299 chr15:72414065 A/G cg16672083 chr15:72433130 SENP8 0.66 15.89 0.53 3.87e-48 Red blood cell count; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg04025307 chr7:1156635 C7orf50 0.61 14.64 0.5 4.41e-42 Longevity;Endometriosis; BRCA trans rs783540 0.632 rs17356528 chr15:83305550 A/G cg16105309 chr15:79090380 ADAMTS7 0.33 9.1 0.34 1.15e-18 Schizophrenia; BRCA cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg04518342 chr5:131593106 PDLIM4 0.35 8.57 0.32 7.71e-17 Blood metabolite levels; BRCA trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg22491629 chr6:157744540 C6orf35 -0.61 -11.13 -0.4 2.06e-26 Hemostatic factors and hematological phenotypes; BRCA cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.03 -0.34 2.02e-18 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.752 rs7529699 chr1:46134634 C/T cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs151349 1.000 rs151344 chr20:57585301 A/G cg23907860 chr20:57583709 CTSZ -0.45 -11.06 -0.4 3.78e-26 Platelet distribution width; BRCA cis rs1595825 0.838 rs58576043 chr2:198524149 C/T cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.91e-15 Ulcerative colitis; BRCA cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.68 0.32 3.31e-17 Glomerular filtration rate (creatinine); BRCA cis rs10739663 0.520 rs13294786 chr9:128156961 A/G cg14078157 chr9:128172775 NA -0.45 -10.44 -0.38 1.12e-23 Resting heart rate; BRCA cis rs1371867 0.846 rs1660330 chr8:101305015 T/A cg06002616 chr8:101225028 SPAG1 -0.34 -8.34 -0.31 4.47e-16 Atrioventricular conduction; BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg26516362 chr5:178986906 RUFY1 0.47 13.56 0.47 5.29e-37 Lung cancer; BRCA cis rs79839061 0.610 rs11733713 chr4:869169 A/G cg07828340 chr4:882639 GAK 1.05 12.4 0.44 8.47e-32 Intelligence (multi-trait analysis); BRCA cis rs7592578 0.825 rs12477369 chr2:191455624 G/T cg10560079 chr2:191398806 TMEM194B 0.68 11.9 0.43 1.23e-29 Diastolic blood pressure; BRCA cis rs12541635 1.000 rs7817197 chr8:107089633 T/G cg10147462 chr8:107024639 NA -0.3 -8.35 -0.31 4.26e-16 Age of smoking initiation; BRCA cis rs9443645 0.869 rs7762022 chr6:79502859 C/A cg09184832 chr6:79620586 NA -0.49 -10.56 -0.39 3.84e-24 Intelligence (multi-trait analysis); BRCA trans rs2832077 0.943 rs2832094 chr21:30165910 G/A cg14791747 chr16:20752902 THUMPD1 0.43 10.27 0.38 5.16e-23 Cognitive test performance; BRCA cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.34e-16 Schizophrenia; BRCA cis rs3772130 0.962 rs4311252 chr3:121514161 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.56 10.58 0.39 3.14e-24 Cognitive performance; BRCA cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg10932868 chr11:921992 NA 0.49 12.53 0.44 2.39e-32 Alzheimer's disease (late onset); BRCA cis rs13031619 1.000 rs13031619 chr2:3698371 A/G cg19052272 chr2:3704530 ALLC 0.54 11.67 0.42 1.21e-28 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg23033748 chr14:75592666 NEK9 -0.4 -9.72 -0.36 6.46e-21 Height; BRCA cis rs2191566 0.960 rs367209 chr19:44506249 A/G cg20607764 chr19:44506953 ZNF230 0.49 10.89 0.4 1.88e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg00701064 chr4:6280414 WFS1 0.63 16.27 0.54 4.64e-50 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs3845702 1.000 rs259808 chr2:180791419 T/G cg01881094 chr2:180872142 CWC22 -0.64 -11.99 -0.43 5.27e-30 Schizophrenia; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg04944784 chr2:26401820 FAM59B 0.97 16.04 0.54 6.42e-49 Gut microbiome composition (summer); BRCA trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg15704280 chr7:45808275 SEPT13 0.6 10.66 0.39 1.57e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs9815354 0.812 rs10510732 chr3:42007339 C/T cg03022575 chr3:42003672 ULK4 0.7 9.86 0.36 1.84e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg02475777 chr4:1388615 CRIPAK 0.4 8.8 0.33 1.28e-17 Longevity; BRCA cis rs11190604 1.000 rs1106565 chr10:102211613 T/C cg07080220 chr10:102295463 HIF1AN 0.48 10.95 0.4 1.07e-25 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.4 0.47 2.76e-36 Platelet count; BRCA cis rs10208940 0.920 rs13417100 chr2:68821725 C/T cg12452813 chr2:68675892 NA -0.46 -8.21 -0.31 1.27e-15 Urate levels in lean individuals; BRCA cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.22 0.37 7.86e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs701145 0.585 rs1727949 chr3:153875713 A/G cg17054900 chr3:154042577 DHX36 0.38 7.85 0.3 1.72e-14 Coronary artery disease; BRCA cis rs11190604 0.767 rs77838250 chr10:102180090 T/G cg07080220 chr10:102295463 HIF1AN 0.49 10.19 0.37 1.07e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs875971 0.862 rs6460290 chr7:65809106 G/A cg18876405 chr7:65276391 NA -0.51 -11.71 -0.42 7.59e-29 Aortic root size; BRCA cis rs17270561 0.609 rs7754733 chr6:25745049 C/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs1865760 0.688 rs1436310 chr6:25969958 G/C cg16482183 chr6:26056742 HIST1H1C 0.5 10.55 0.39 4.35e-24 Height; BRCA cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg11764359 chr7:65958608 NA 0.62 10.67 0.39 1.44e-24 Aortic root size; BRCA cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg26384229 chr12:38710491 ALG10B -0.64 -15.14 -0.51 1.86e-44 Drug-induced liver injury (flucloxacillin); BRCA cis rs1577917 0.958 rs34795473 chr6:86461799 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -7.88 -0.3 1.43e-14 Response to antipsychotic treatment; BRCA cis rs11229555 1.000 rs2275993 chr11:58379987 A/G cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.59 0.32 6.43e-17 Glomerular filtration rate (creatinine); BRCA cis rs4711336 1.000 rs3818523 chr6:33660371 G/A cg14003231 chr6:33640908 ITPR3 0.32 7.85 0.3 1.79e-14 Height; BRCA trans rs12310956 0.527 rs1608910 chr12:33895414 T/C cg26384229 chr12:38710491 ALG10B 0.46 10.71 0.39 9.85e-25 Morning vs. evening chronotype; BRCA cis rs1011018 0.590 rs76304235 chr7:139456611 C/T cg03224163 chr7:139420300 HIPK2 -0.59 -8.83 -0.33 1.01e-17 Systolic blood pressure; BRCA cis rs4891159 0.548 rs609487 chr18:74134382 C/G cg24786174 chr18:74118243 ZNF516 -0.83 -24.36 -0.69 3.19e-93 Longevity; BRCA cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg15145296 chr3:125709740 NA -0.56 -8.89 -0.33 6.25e-18 Blood pressure (smoking interaction); BRCA cis rs6545883 0.831 rs1186704 chr2:61672991 A/G cg15711740 chr2:61764176 XPO1 -0.57 -14.41 -0.5 5.74e-41 Tuberculosis; BRCA cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs56399783 0.614 rs55776032 chr7:2762255 T/C cg19731401 chr7:2775893 GNA12 0.54 8.37 0.31 3.76e-16 Childhood ear infection; BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg12444411 chr7:2802554 GNA12 -0.36 -8.83 -0.33 9.63e-18 Height; BRCA cis rs4285028 0.948 rs34696871 chr3:121671880 T/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.6 -11.09 -0.4 2.81e-26 Multiple sclerosis; BRCA cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg21535247 chr6:8435926 SLC35B3 0.41 9.38 0.35 1.09e-19 Motion sickness; BRCA cis rs778371 0.630 rs13007579 chr2:233725364 G/A cg08000102 chr2:233561755 GIGYF2 -0.78 -16.46 -0.55 5.45e-51 Schizophrenia; BRCA cis rs10782582 0.617 rs1846233 chr1:76159354 C/T cg03433033 chr1:76189801 ACADM -0.47 -9.85 -0.36 2.02e-21 Daytime sleep phenotypes; BRCA cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg08999081 chr20:33150536 PIGU -0.39 -10.82 -0.39 3.64e-25 Glomerular filtration rate (creatinine); BRCA cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg00106254 chr7:1943704 MAD1L1 -0.31 -8.32 -0.31 5.13e-16 Bipolar disorder and schizophrenia; BRCA cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg16339924 chr4:17578868 LAP3 0.63 15.65 0.53 5.38e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs941873 0.900 rs4979861 chr10:81131595 A/G cg11057378 chr10:81107060 PPIF 0.43 10.07 0.37 3.02e-22 Height; BRCA cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.65 0.36 1.16e-20 Menopause (age at onset); BRCA trans rs11098499 0.570 rs6832740 chr4:120546136 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.11 0.37 2.1e-22 Corneal astigmatism; BRCA cis rs10242455 0.702 rs73401510 chr7:99065812 A/C cg18809830 chr7:99032528 PTCD1 -0.6 -8.57 -0.32 7.71e-17 Blood metabolite levels; BRCA cis rs7824557 0.737 rs2293855 chr8:11177410 G/A cg21775007 chr8:11205619 TDH 0.64 12.66 0.45 6.04e-33 Retinal vascular caliber; BRCA cis rs9304742 0.573 rs10415950 chr19:53465100 C/T cg09915433 chr19:53449742 NA -0.45 -9.05 -0.34 1.74e-18 Psoriasis; BRCA cis rs4319547 0.915 rs3803005 chr12:123110654 T/C cg23029597 chr12:123009494 RSRC2 -0.59 -12.19 -0.43 6.95e-31 Body mass index; BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg13880726 chr7:1868755 MAD1L1 0.52 9.67 0.36 9.98e-21 Bipolar disorder and schizophrenia; BRCA cis rs4363385 0.747 rs4845332 chr1:152982632 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.15e-18 Inflammatory skin disease; BRCA cis rs9420 0.807 rs12807357 chr11:57656902 C/T cg19752551 chr11:57585705 CTNND1 -0.52 -12.36 -0.44 1.32e-31 Schizophrenia; BRCA cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.12 -0.58 1.55e-59 Extrinsic epigenetic age acceleration; BRCA cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg11812906 chr14:75593930 NEK9 0.7 16.14 0.54 2.21e-49 Height; BRCA cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11644478 chr21:40555479 PSMG1 0.67 15.08 0.51 3.37e-44 Cognitive function; BRCA cis rs28374715 0.681 rs28728213 chr15:41653602 T/A cg18705301 chr15:41695430 NDUFAF1 -0.84 -19.64 -0.61 1.6e-67 Ulcerative colitis; BRCA cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg13334819 chr7:99746414 C7orf59 -0.43 -10.03 -0.37 4.43e-22 Coronary artery disease; BRCA cis rs1499972 0.941 rs62266129 chr3:117590704 G/C cg07612923 chr3:117604196 NA 0.58 7.85 0.3 1.75e-14 Schizophrenia; BRCA cis rs6089829 0.962 rs6089825 chr20:61668447 C/T cg02544614 chr20:61657117 NA 0.28 8.0 0.3 5.65e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7072216 0.763 rs2147900 chr10:100174721 T/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.63 -0.36 1.38e-20 Metabolite levels; BRCA cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg21132104 chr15:45694354 SPATA5L1 0.7 15.33 0.52 2.18e-45 Homoarginine levels; BRCA cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg22875332 chr1:76189707 ACADM 0.69 14.82 0.51 6.29e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.830 rs28619044 chr4:98789814 G/C cg05340658 chr4:99064831 C4orf37 0.62 14.94 0.51 1.58e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 0.803 rs36127118 chr7:65565505 A/G cg18252515 chr7:66147081 NA -1.06 -15.33 -0.52 2.15e-45 Diabetic kidney disease; BRCA cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg16179182 chr5:140090404 VTRNA1-1 0.41 9.51 0.35 3.8e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.61 -11.8 -0.42 3.35e-29 Gut microbiome composition (summer); BRCA cis rs6835098 0.961 rs1574314 chr4:174106663 C/T cg27433088 chr4:174089019 GALNT7 0.34 9.13 0.34 8.82e-19 Dementia and core Alzheimer's disease neuropathologic changes; BRCA trans rs11039798 0.512 rs1988465 chr11:49011303 C/T cg03929089 chr4:120376271 NA 0.58 9.32 0.35 1.86e-19 Axial length; BRCA cis rs2652834 1.000 rs2729830 chr15:63395812 G/C cg05507819 chr15:63340323 TPM1 0.45 8.39 0.32 3.12e-16 HDL cholesterol; BRCA cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg00530320 chr1:46809349 NSUN4 0.49 9.7 0.36 7.91e-21 Menopause (age at onset); BRCA cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg05347473 chr6:146136440 FBXO30 0.42 8.35 0.31 4.18e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg13010199 chr12:38710504 ALG10B 0.52 10.89 0.4 1.89e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs2882667 0.690 rs1976562 chr5:138110594 G/A cg04439458 chr5:138467593 SIL1 0.34 8.41 0.32 2.59e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg11663144 chr21:46675770 NA -0.54 -12.7 -0.45 4.17e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg21433313 chr16:3507492 NAT15 -0.59 -8.03 -0.3 4.64e-15 Tuberculosis; BRCA cis rs2625529 0.730 rs7177242 chr15:72184114 A/G cg16672083 chr15:72433130 SENP8 0.7 16.35 0.54 1.85e-50 Red blood cell count; BRCA cis rs3099143 1.000 rs3102710 chr15:77061148 T/C cg21673338 chr15:77095150 SCAPER -0.54 -9.77 -0.36 4.18e-21 Recalcitrant atopic dermatitis; BRCA cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg20503657 chr10:835505 NA -0.65 -13.31 -0.47 7.34e-36 Eosinophil percentage of granulocytes; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.48 -7.84 -0.3 1.91e-14 Gut microbiome composition (summer); BRCA cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.72 16.84 0.55 6e-53 Multiple sclerosis; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg27170947 chr2:26402098 FAM59B 0.65 11.1 0.4 2.63e-26 Gut microbiome composition (summer); BRCA cis rs7493 0.755 rs116306774 chr7:95016976 G/A cg19678392 chr7:94953810 PON1 -0.42 -8.91 -0.33 5.18e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9469890 0.604 rs11758420 chr6:34503279 A/C cg14254433 chr6:34482411 PACSIN1 -0.44 -9.07 -0.34 1.44e-18 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs7267979 0.932 rs6037125 chr20:25463382 G/A cg08601574 chr20:25228251 PYGB 0.33 8.2 0.31 1.37e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg05283184 chr6:79620031 NA -0.43 -10.98 -0.4 8.25e-26 Intelligence (multi-trait analysis); BRCA cis rs4481887 0.927 rs4586010 chr1:248437568 G/A cg00666640 chr1:248458726 OR2T12 0.31 8.54 0.32 1.01e-16 Common traits (Other); BRCA cis rs921968 0.643 rs485765 chr2:219480804 C/G cg02176678 chr2:219576539 TTLL4 0.37 9.58 0.35 2.15e-20 Mean corpuscular hemoglobin concentration; BRCA cis rs922692 0.744 rs11072806 chr15:79079074 G/A cg04896959 chr15:78267971 NA 0.37 8.61 0.32 5.5e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs932287 0.540 rs4910442 chr11:9044337 T/C cg12365402 chr11:9010492 NRIP3 0.43 9.11 0.34 1.06e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs3820928 0.874 rs4675128 chr2:227814757 T/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.31 -0.31 5.79e-16 Pulmonary function; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.05 0.6 1.94e-64 Platelet count; BRCA cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg01475377 chr6:109611718 NA -0.52 -13.09 -0.46 7.37e-35 Reticulocyte fraction of red cells; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.7 10.61 0.39 2.47e-24 Lung function (FEV1/FVC); BRCA cis rs1577917 1.000 rs12215037 chr6:86727631 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -8.52 -0.32 1.11e-16 Response to antipsychotic treatment; BRCA cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg04455712 chr21:45112962 RRP1B 0.36 9.4 0.35 9.96e-20 Mean corpuscular volume; BRCA cis rs908922 0.676 rs1856120 chr1:152512441 G/A cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 14.7 0.5 2.4e-42 Platelet count; BRCA cis rs1878931 0.582 rs27225 chr16:3428060 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.52 -9.01 -0.34 2.37e-18 Body mass index (adult); BRCA trans rs11976180 1.000 rs2961125 chr7:143761770 T/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.49 10.06 0.37 3.43e-22 Personality dimensions; BRCA cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg08822215 chr16:89438651 ANKRD11 -0.4 -8.51 -0.32 1.28e-16 Multiple myeloma (IgH translocation); BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg23708337 chr7:1209742 NA 0.64 8.74 0.33 2.05e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs6952808 0.771 rs10244946 chr7:1921068 A/G cg04565464 chr8:145669602 NFKBIL2 -0.36 -8.88 -0.33 6.52e-18 Bipolar disorder and schizophrenia; BRCA cis rs1707322 0.686 rs61784833 chr1:46233772 T/C cg06784218 chr1:46089804 CCDC17 0.5 12.11 0.43 1.61e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7254114 0.578 rs35248735 chr19:11312238 G/A cg06870470 chr19:11315767 DOCK6 -0.36 -8.35 -0.31 4.25e-16 Immature fraction of reticulocytes; BRCA cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg12373951 chr3:133503437 NA 0.45 10.74 0.39 7.77e-25 Iron status biomarkers; BRCA cis rs7666738 0.830 rs7687315 chr4:98900613 A/G cg17366294 chr4:99064904 C4orf37 0.42 9.88 0.36 1.61e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs9354352 0.967 rs9354351 chr6:66696271 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 13.25 0.46 1.4e-35 Initial pursuit acceleration in psychotic disorders; BRCA cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -10.21 -0.37 8.93e-23 Mood instability; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.84 0.55 6.2e-53 Gut microbiome composition (summer); BRCA cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.55 -0.32 8.83e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs3768617 0.510 rs10797842 chr1:183081867 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 18.19 0.58 6.66e-60 Fuchs's corneal dystrophy; BRCA cis rs3858526 0.883 rs10769333 chr11:5939685 A/T cg05234568 chr11:5960015 NA -0.47 -9.29 -0.34 2.45e-19 DNA methylation (variation); BRCA cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.77 11.32 0.41 3.31e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs60843830 1.000 rs2290911 chr2:224919 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.73 14.58 0.5 9.37e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6138458 1.000 rs227632 chr20:24913729 G/A cg26195577 chr20:24973756 C20orf3 1.03 26.67 0.73 6.44e-106 Blood protein levels; BRCA cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12210905 0.688 rs12191373 chr6:27484330 C/T cg08851530 chr6:28072375 NA 0.81 7.82 0.3 2.22e-14 Hip circumference adjusted for BMI; BRCA cis rs7412746 0.634 rs3754212 chr1:150738200 A/G cg15448220 chr1:150897856 SETDB1 0.36 8.1 0.31 2.79e-15 Melanoma; BRCA cis rs3768617 0.727 rs12066735 chr1:183101451 T/G ch.1.3577855R chr1:183094577 LAMC1 0.47 10.56 0.39 3.97e-24 Fuchs's corneal dystrophy; BRCA cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg10523679 chr1:76189770 ACADM -0.46 -8.86 -0.33 7.57e-18 Daytime sleep phenotypes; BRCA cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg20891283 chr12:69753455 YEATS4 0.73 22.1 0.66 7.57e-81 Blood protein levels; BRCA cis rs7301826 0.580 rs61938969 chr12:131316070 A/G cg11011512 chr12:131303247 STX2 -0.44 -11.11 -0.4 2.52e-26 Plasma plasminogen activator levels; BRCA cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg14558114 chr2:88469736 THNSL2 -0.54 -11.32 -0.41 3.22e-27 Response to metformin (IC50); BRCA cis rs711245 0.545 rs848617 chr2:36811298 G/C cg01206211 chr2:36825736 FEZ2 0.41 9.92 0.37 1.11e-21 Height; BRCA cis rs4845570 1.000 rs6659705 chr1:151769750 T/C cg07092448 chr1:151763213 TDRKH -0.88 -18.58 -0.59 6.15e-62 Coronary artery disease; BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs7945705 0.747 rs2568045 chr11:9004060 T/C cg12365402 chr11:9010492 NRIP3 -0.42 -9.85 -0.36 2.09e-21 Hemoglobin concentration; BRCA cis rs7178424 1.000 rs12438690 chr15:62380390 T/C cg00456672 chr15:62358751 C2CD4A -0.34 -8.2 -0.31 1.28e-15 Height; BRCA cis rs3820928 0.904 rs1835159 chr2:227764057 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.35 -0.31 4.31e-16 Pulmonary function; BRCA cis rs35110281 0.776 rs2838316 chr21:44990036 C/T cg21573476 chr21:45109991 RRP1B -0.33 -8.47 -0.32 1.71e-16 Mean corpuscular volume; BRCA cis rs3008870 0.628 rs2755257 chr1:67515309 C/T cg02640540 chr1:67518911 SLC35D1 0.41 8.79 0.33 1.39e-17 Lymphocyte percentage of white cells; BRCA cis rs13315871 1.000 rs9821570 chr3:58335919 C/G cg20936604 chr3:58311152 NA -0.62 -8.04 -0.3 4.5e-15 Cholesterol, total; BRCA cis rs9467773 0.967 rs1056347 chr6:26527524 G/C cg09904177 chr6:26538194 HMGN4 0.57 18.57 0.59 6.99e-62 Intelligence (multi-trait analysis); BRCA cis rs724568 0.546 rs974482 chr2:67946520 C/A cg14046302 chr2:67939758 NA -0.4 -10.78 -0.39 5.03e-25 Major depressive disorder (broad); BRCA cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg08000102 chr2:233561755 GIGYF2 -0.47 -10.15 -0.37 1.53e-22 Coronary artery disease; BRCA cis rs57590327 0.503 rs11711024 chr3:81910207 T/C cg07356753 chr3:81810745 GBE1 -0.45 -10.47 -0.38 9.1e-24 Extraversion; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.64 -0.36 1.21e-20 Total body bone mineral density; BRCA trans rs9291683 0.566 rs13115776 chr4:10040189 C/G cg26043149 chr18:55253948 FECH 0.38 8.33 0.31 4.8e-16 Bone mineral density; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg22903471 chr2:27725779 GCKR -0.39 -9.68 -0.36 8.76e-21 Total body bone mineral density; BRCA cis rs6963495 0.818 rs818621 chr7:105173029 T/C cg19920283 chr7:105172520 RINT1 0.65 12.93 0.46 3.95e-34 Bipolar disorder (body mass index interaction); BRCA cis rs11719291 0.833 rs34037363 chr3:48821036 C/T cg00383909 chr3:49044727 WDR6 0.97 15.72 0.53 2.46e-47 Cognitive function; BRCA cis rs9467773 0.584 rs1021372 chr6:26632444 T/C cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.68e-30 Intelligence (multi-trait analysis); BRCA cis rs1372520 0.808 rs1372518 chr4:90757294 A/C cg15133208 chr4:90757351 SNCA -0.44 -9.01 -0.34 2.31e-18 Neuroticism; BRCA cis rs867371 1.000 rs1846911 chr15:82468650 G/A cg00614314 chr15:82944287 LOC80154 0.43 9.06 0.34 1.52e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg00409905 chr10:38381863 ZNF37A -0.49 -10.42 -0.38 1.34e-23 Extrinsic epigenetic age acceleration; BRCA cis rs6952809 0.532 rs6953297 chr7:2440874 C/G cg23289794 chr7:2394357 EIF3B -0.57 -10.98 -0.4 8.42e-26 Multiple sclerosis; BRCA cis rs600806 0.778 rs11101962 chr1:110014187 A/T cg20591472 chr1:110008990 SYPL2 0.31 7.9 0.3 1.25e-14 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg13880726 chr7:1868755 MAD1L1 0.51 10.14 0.37 1.6e-22 Bipolar disorder and schizophrenia; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg09436375 chr6:42928200 GNMT -0.28 -10.49 -0.38 7.59e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 12.1 0.43 1.72e-30 Mean platelet volume; BRCA cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg08601574 chr20:25228251 PYGB 0.33 7.94 0.3 9.38e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg02475777 chr4:1388615 CRIPAK 0.41 9.0 0.34 2.57e-18 Longevity; BRCA cis rs6545883 0.868 rs6545887 chr2:61828818 C/G cg15711740 chr2:61764176 XPO1 -0.55 -14.16 -0.49 8.88e-40 Tuberculosis; BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg21782813 chr7:2030301 MAD1L1 -0.39 -10.13 -0.37 1.8e-22 Bipolar disorder and schizophrenia; BRCA cis rs1580019 0.922 rs59938271 chr7:32484844 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.43 8.89 0.33 6.34e-18 Cognitive ability; BRCA cis rs2075371 0.734 rs13225086 chr7:134011411 C/T cg11752832 chr7:134001865 SLC35B4 0.49 11.48 0.41 7.31e-28 Mean platelet volume; BRCA cis rs4363385 0.747 rs4845507 chr1:152968414 T/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.08 -0.34 1.35e-18 Inflammatory skin disease; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg11843238 chr5:131593191 PDLIM4 -0.43 -11.24 -0.41 7.28e-27 Acylcarnitine levels; BRCA cis rs9287719 0.578 rs62127189 chr2:10761326 T/C cg00105475 chr2:10696890 NA 0.47 10.32 0.38 3.51e-23 Prostate cancer; BRCA cis rs312274 0.588 rs7309918 chr12:41306612 A/G cg17827154 chr12:41323612 CNTN1 -0.44 -11.03 -0.4 5.14e-26 Metabolite levels (X-11787); BRCA trans rs66887589 0.934 rs12648182 chr4:120503891 T/A cg25214090 chr10:38739885 LOC399744 -0.36 -8.35 -0.31 4.21e-16 Diastolic blood pressure; BRCA cis rs12497850 0.864 rs4513485 chr3:49139966 G/A cg07636037 chr3:49044803 WDR6 0.94 26.68 0.73 6.17e-106 Parkinson's disease; BRCA cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.75 -0.53 1.79e-47 Chronic sinus infection; BRCA cis rs7618915 0.501 rs11714030 chr3:52765882 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.07 0.4 3.59e-26 Bipolar disorder; BRCA cis rs55665837 1.000 rs10832269 chr11:14465069 C/A cg19336497 chr11:14380999 RRAS2 -0.37 -9.77 -0.36 4.22e-21 Vitamin D levels; BRCA cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg27129171 chr3:47204927 SETD2 0.71 17.18 0.56 1.13e-54 Colorectal cancer; BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg07256732 chr16:621771 PIGQ -0.35 -9.4 -0.35 9.36e-20 Height; BRCA cis rs11229555 0.645 rs7929028 chr11:58188258 C/T cg15696309 chr11:58395628 NA -0.45 -9.74 -0.36 5.49e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs60843830 0.633 rs1078763 chr2:113763 A/G cg25945732 chr2:264204 ACP1;SH3YL1 -0.45 -9.06 -0.34 1.6e-18 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4664304 0.620 rs10929957 chr2:160716508 A/G cg14819504 chr2:160761413 LY75 0.34 8.22 0.31 1.17e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6545883 0.899 rs1562309 chr2:61770126 C/A cg15711740 chr2:61764176 XPO1 -0.57 -14.53 -0.5 1.51e-41 Tuberculosis; BRCA cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg24642439 chr20:33292090 TP53INP2 -0.54 -11.77 -0.42 4.23e-29 Glomerular filtration rate (creatinine); BRCA cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -13.06 -0.46 1.04e-34 Chronic sinus infection; BRCA cis rs9287719 0.967 rs2010073 chr2:10736478 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs4728302 0.869 rs7792492 chr7:133595316 C/T cg07491979 chr7:133331646 EXOC4 0.36 7.86 0.3 1.66e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs6062302 0.522 rs4809312 chr20:62234240 C/T cg16989086 chr20:62203971 PRIC285 0.52 8.77 0.33 1.61e-17 Glioblastoma; BRCA cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg13047869 chr3:10149882 C3orf24 0.6 12.62 0.45 9.38e-33 Alzheimer's disease; BRCA cis rs17741873 0.779 rs12573092 chr10:75600016 A/G cg07699608 chr10:75541558 CHCHD1 0.49 8.03 0.3 4.73e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs9325144 0.560 rs1825802 chr12:38650341 C/T cg13010199 chr12:38710504 ALG10B -0.36 -8.77 -0.33 1.6e-17 Morning vs. evening chronotype; BRCA trans rs6601450 0.547 rs10105843 chr8:10197863 A/G cg06636001 chr8:8085503 FLJ10661 0.52 11.02 0.4 5.61e-26 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4891159 0.790 rs72975930 chr18:74144645 G/A cg24786174 chr18:74118243 ZNF516 -0.77 -18.16 -0.58 1.02e-59 Longevity; BRCA cis rs10788264 0.621 rs9633734 chr10:124057667 T/C cg09507567 chr10:124027408 NA 0.41 8.43 0.32 2.27e-16 Total body bone mineral density; BRCA cis rs9467773 0.596 rs3001369 chr6:26670969 C/T cg09904177 chr6:26538194 HMGN4 0.44 13.69 0.48 1.41e-37 Intelligence (multi-trait analysis); BRCA cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg11952622 chr19:58962976 ZNF324B 0.43 8.8 0.33 1.31e-17 Uric acid clearance; BRCA cis rs2777491 1.000 rs1757455 chr15:41761332 G/T cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.99 -0.53 1.22e-48 Ulcerative colitis; BRCA cis rs11711311 1.000 rs9811746 chr3:113515060 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.15 -0.37 1.5e-22 IgG glycosylation; BRCA cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.28e-32 Breast cancer; BRCA cis rs7945705 0.935 rs2653567 chr11:8889630 T/C cg12365402 chr11:9010492 NRIP3 -0.37 -8.5 -0.32 1.39e-16 Hemoglobin concentration; BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg12564285 chr5:131593104 PDLIM4 0.36 9.78 0.36 3.97e-21 Breast cancer; BRCA cis rs11585357 0.947 rs11585119 chr1:17605792 C/A cg08277548 chr1:17600880 PADI3 -0.74 -12.09 -0.43 1.9e-30 Hair shape; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg23978390 chr7:1156363 C7orf50 0.37 8.79 0.33 1.42e-17 Longevity;Endometriosis; BRCA cis rs9354352 0.935 rs7766730 chr6:66697003 C/A cg07460842 chr6:66804631 NA 0.64 13.81 0.48 3.7e-38 Initial pursuit acceleration in psychotic disorders; BRCA cis rs870825 0.929 rs72689255 chr4:185590141 T/C cg04058563 chr4:185651563 MLF1IP 0.88 14.47 0.5 3.03e-41 Blood protein levels; BRCA cis rs473651 0.935 rs515412 chr2:239345394 A/T cg21699342 chr2:239360505 ASB1 0.52 13.74 0.48 8.19e-38 Multiple system atrophy; BRCA cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg18132916 chr6:79620363 NA -0.44 -10.07 -0.37 3.15e-22 Intelligence (multi-trait analysis); BRCA cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg26850624 chr5:429559 AHRR 0.33 7.92 0.3 1.09e-14 Cystic fibrosis severity; BRCA cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg13010199 chr12:38710504 ALG10B -0.39 -8.42 -0.32 2.49e-16 Bladder cancer; BRCA cis rs7726839 0.561 rs4957048 chr5:583442 G/A cg09021430 chr5:549028 NA -0.64 -15.31 -0.52 2.54e-45 Obesity-related traits; BRCA cis rs6761276 0.674 rs3811056 chr2:113831183 T/C cg12858261 chr2:113808755 IL1F8 0.43 8.53 0.32 1.1e-16 Protein quantitative trait loci; BRCA cis rs2439831 0.850 rs12442297 chr15:44168470 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.46 0.35 5.62e-20 Lung cancer in ever smokers; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg15112475 chr7:1198522 ZFAND2A -0.57 -12.96 -0.46 2.86e-34 Longevity;Endometriosis; BRCA cis rs1467026 0.563 rs58674721 chr3:12811233 G/A cg24848339 chr3:12840334 CAND2 0.38 9.49 0.35 4.69e-20 P wave duration; BRCA cis rs17270561 0.666 rs1937129 chr6:25789132 A/G cg16482183 chr6:26056742 HIST1H1C 0.44 9.03 0.34 1.93e-18 Iron status biomarkers; BRCA cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg01877450 chr7:97915802 BRI3 0.38 8.6 0.32 5.98e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg21280719 chr6:42927975 GNMT -0.33 -13.97 -0.48 6.79e-39 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs586533 0.837 rs637745 chr11:99495452 C/G cg22878054 chr11:99397252 CNTN5 0.32 8.03 0.3 4.8e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9296095 0.747 rs12206050 chr6:33564296 A/T cg14003231 chr6:33640908 ITPR3 0.45 9.48 0.35 4.99e-20 Platelet count; BRCA cis rs10504229 0.683 rs66730544 chr8:58127280 A/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs1595825 0.891 rs79845692 chr2:198523541 T/C cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.91e-15 Ulcerative colitis; BRCA cis rs7633770 0.841 rs11709020 chr3:46680063 A/G cg11219411 chr3:46661640 NA -0.68 -18.04 -0.58 3.99e-59 Coronary artery disease; BRCA cis rs600231 0.542 rs10896010 chr11:65246220 C/A cg01292856 chr11:65242576 NA 0.65 14.99 0.51 9.61e-44 Bone mineral density; BRCA cis rs6582630 0.531 rs3850000 chr12:38483752 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs4237845 0.537 rs12312955 chr12:58265223 A/G cg00677455 chr12:58241039 CTDSP2 0.68 15.77 0.53 1.38e-47 Intelligence (multi-trait analysis); BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19717773 chr7:2847554 GNA12 -0.41 -7.94 -0.3 9.46e-15 Height; BRCA trans rs9325144 0.600 rs11183505 chr12:38759110 G/T cg23762105 chr12:34175262 ALG10 0.36 8.49 0.32 1.45e-16 Morning vs. evening chronotype; BRCA cis rs2806561 0.828 rs604030 chr1:23518227 T/C cg12483005 chr1:23474871 LUZP1 0.44 9.7 0.36 7.48e-21 Height; BRCA cis rs11622475 1.000 rs10149651 chr14:104394440 A/G cg12183467 chr14:104352244 NA 0.47 9.79 0.36 3.65e-21 Bipolar disorder; BRCA cis rs4478858 0.595 rs4949387 chr1:31803440 T/A cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA trans rs867371 0.502 rs7176926 chr15:82538094 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.31 -8.5 -0.32 1.38e-16 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs1971762 0.563 rs10747678 chr12:54077687 A/C cg23533419 chr12:54090519 NA 0.32 8.11 0.31 2.52e-15 Height; BRCA cis rs10044254 0.563 rs16867538 chr5:15680744 A/G cg07238450 chr5:15720153 FBXL7 -0.46 -11.04 -0.4 4.79e-26 Asthma (corticosteroid response); BRCA cis rs72781680 0.716 rs78332127 chr2:24150163 C/G cg08917208 chr2:24149416 ATAD2B 0.63 10.68 0.39 1.25e-24 Lymphocyte counts; BRCA cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg23711669 chr6:146136114 FBXO30 0.72 14.6 0.5 7.21e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7607369 0.536 rs13033409 chr2:219666509 T/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.09 -0.37 2.52e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs4988958 0.565 rs1035125 chr2:103033839 C/A cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma (childhood onset); BRCA cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg15839431 chr19:19639596 YJEFN3 0.42 8.55 0.32 8.9e-17 Bipolar disorder; BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg27170947 chr2:26402098 FAM59B 0.78 11.19 0.4 1.16e-26 Gut microbiome composition (summer); BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.12 0.34 9.39e-19 Tonsillectomy; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg05896524 chr21:47604654 C21orf56 0.51 10.49 0.38 7.13e-24 Testicular germ cell tumor; BRCA trans rs11039798 0.511 rs2047812 chr11:48162042 A/G cg15704280 chr7:45808275 SEPT13 -0.5 -8.38 -0.31 3.46e-16 Axial length; BRCA cis rs56104184 0.775 rs55756106 chr19:49403055 A/G cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7103648 0.966 rs10838702 chr11:47410888 G/T cg03711944 chr11:47377212 SPI1 -0.4 -10.97 -0.4 9.34e-26 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6500602 0.701 rs4785968 chr16:4535307 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.36 7.81 0.3 2.33e-14 Schizophrenia; BRCA cis rs7809950 0.906 rs2395907 chr7:107253304 A/G cg23024343 chr7:107201750 COG5 0.38 8.37 0.31 3.66e-16 Coronary artery disease; BRCA cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg03676636 chr4:99064102 C4orf37 -0.22 -8.36 -0.31 3.82e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs2839186 0.934 rs13049797 chr21:47707582 T/C cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.16 -0.58 1.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg14403583 chr14:105418241 AHNAK2 -0.39 -9.05 -0.34 1.75e-18 Rheumatoid arthritis; BRCA cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg11663144 chr21:46675770 NA -0.55 -12.96 -0.46 2.93e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1707322 0.721 rs4660883 chr1:46236098 C/T cg06784218 chr1:46089804 CCDC17 0.49 11.73 0.42 6.5e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg26446133 chr18:72167187 CNDP2 -0.78 -14.29 -0.49 2.2e-40 Refractive error; BRCA cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.08 -0.58 2.61e-59 Extrinsic epigenetic age acceleration; BRCA cis rs6835098 0.924 rs13138282 chr4:174120906 C/T cg08422745 chr4:174089978 GALNT7 0.81 15.25 0.52 4.94e-45 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.32 -0.38 3.23e-23 Psoriasis; BRCA trans rs3780486 0.846 rs10813948 chr9:33121570 G/A cg20290983 chr6:43655470 MRPS18A 1.12 40.58 0.85 5.18e-179 IgG glycosylation; BRCA cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 14.17 0.49 7.97e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4808199 0.947 rs1465695 chr19:19588546 A/C cg03709012 chr19:19516395 GATAD2A 1.08 21.21 0.64 5.21e-76 Nonalcoholic fatty liver disease; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg03188948 chr7:1209495 NA 0.82 11.41 0.41 1.43e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.9 -0.4 1.77e-25 Bone mineral density; BRCA cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg05347473 chr6:146136440 FBXO30 0.41 7.97 0.3 7.08e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg02733842 chr7:1102375 C7orf50 0.61 11.69 0.42 9.39e-29 Bronchopulmonary dysplasia; BRCA cis rs9341808 0.935 rs2298307 chr6:80816296 A/G cg08355045 chr6:80787529 NA 0.32 8.21 0.31 1.27e-15 Sitting height ratio; BRCA cis rs11098499 0.954 rs7437420 chr4:120312903 A/G cg09307838 chr4:120376055 NA 0.73 16.05 0.54 6.21e-49 Corneal astigmatism; BRCA cis rs7727544 0.684 rs272849 chr5:131690241 A/G cg07395648 chr5:131743802 NA -0.39 -9.67 -0.36 9.64e-21 Blood metabolite levels; BRCA cis rs4363385 0.818 rs946096 chr1:153006529 T/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg05347473 chr6:146136440 FBXO30 0.43 8.73 0.33 2.26e-17 Lobe attachment (rater-scored or self-reported); BRCA trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg15704280 chr7:45808275 SEPT13 -0.68 -12.81 -0.45 1.39e-33 Coronary artery disease; BRCA cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.13 0.37 1.82e-22 Aortic root size; BRCA cis rs34779708 0.966 rs34630580 chr10:35449228 A/G cg03585969 chr10:35415529 CREM 0.55 11.46 0.41 8.4e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7666738 0.830 rs10028692 chr4:98962585 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.96 0.56 1.53e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs28830936 0.966 rs62002090 chr15:42092326 C/T cg17847044 chr15:42102381 MAPKBP1 -0.36 -9.67 -0.36 9.65e-21 Diastolic blood pressure; BRCA cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg06917634 chr15:78832804 PSMA4 -0.76 -17.81 -0.58 6.52e-58 Sudden cardiac arrest; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.37 -8.62 -0.32 5.4e-17 Longevity;Endometriosis; BRCA trans rs6089829 0.855 rs6062781 chr20:61667128 G/A cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs17092148 0.887 rs6059928 chr20:33167349 A/G cg16810054 chr20:33298113 TP53INP2 -0.45 -10.26 -0.38 5.94e-23 Neuroticism; BRCA cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg00105475 chr2:10696890 NA -0.45 -10.5 -0.38 6.47e-24 Prostate cancer; BRCA cis rs140365914 1 rs140365914 chr7:155106570 C/T cg04811098 chr7:155088454 INSIG1 0.39 10.26 0.38 5.76e-23 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs35110281 0.744 rs162396 chr21:44947807 T/C cg21573476 chr21:45109991 RRP1B -0.37 -9.55 -0.35 2.62e-20 Mean corpuscular volume; BRCA cis rs9733 0.519 rs11204717 chr1:150709129 T/A cg17724175 chr1:150552817 MCL1 0.25 8.34 0.31 4.51e-16 Tonsillectomy; BRCA cis rs66887589 0.560 rs9684327 chr4:120365441 A/G cg09307838 chr4:120376055 NA 0.47 9.82 0.36 2.6e-21 Diastolic blood pressure; BRCA cis rs875971 0.964 rs697969 chr7:65558478 C/A cg18876405 chr7:65276391 NA -0.57 -13.43 -0.47 2.16e-36 Aortic root size; BRCA cis rs9457247 0.508 rs9459874 chr6:167504127 A/G cg07741184 chr6:167504864 NA -0.3 -9.32 -0.35 1.83e-19 Crohn's disease; BRCA cis rs2404602 0.735 rs2048856 chr15:76800083 C/T cg23625390 chr15:77176239 SCAPER -0.48 -11.45 -0.41 9.25e-28 Blood metabolite levels; BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg21782813 chr7:2030301 MAD1L1 0.38 9.71 0.36 6.79e-21 Bipolar disorder and schizophrenia; BRCA cis rs11711311 0.747 rs9882193 chr3:113349451 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.4 8.86 0.33 7.9e-18 IgG glycosylation; BRCA cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg19729930 chr2:74357872 NA 0.54 13.63 0.47 2.51e-37 Gestational age at birth (maternal effect); BRCA cis rs12618769 0.597 rs3769725 chr2:99105967 A/G cg10123293 chr2:99228465 UNC50 0.42 8.43 0.32 2.38e-16 Bipolar disorder; BRCA cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06022373 chr22:39101656 GTPBP1 -0.63 -16.42 -0.54 8.59e-51 Menopause (age at onset); BRCA trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg15704280 chr7:45808275 SEPT13 -0.71 -14.29 -0.49 2.19e-40 Coronary artery disease; BRCA cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg24549020 chr5:56110836 MAP3K1 0.63 12.25 0.44 3.71e-31 Initial pursuit acceleration; BRCA trans rs11098499 0.863 rs10030660 chr4:120436704 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.33 0.44 1.68e-31 Corneal astigmatism; BRCA cis rs250677 0.522 rs6580589 chr5:148360335 C/G cg18129178 chr5:148520854 ABLIM3 0.54 10.41 0.38 1.57e-23 Breast cancer; BRCA cis rs11690935 1.000 rs35549875 chr2:172532392 A/G cg13550731 chr2:172543902 DYNC1I2 0.93 29.85 0.76 2.88e-123 Schizophrenia; BRCA cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.02e-40 Motion sickness; BRCA cis rs72781680 1.000 rs72781631 chr2:24195064 G/A cg08917208 chr2:24149416 ATAD2B 0.83 12.76 0.45 2.17e-33 Lymphocyte counts; BRCA cis rs427394 0.802 rs274712 chr5:6723950 G/A cg10857441 chr5:6722123 POLS -0.33 -10.97 -0.4 8.68e-26 Menopause (age at onset); BRCA cis rs16944613 0.541 rs4288973 chr15:91093676 G/A cg26821196 chr15:91095069 CRTC3 0.48 8.81 0.33 1.22e-17 Colorectal cancer; BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg25036284 chr2:26402008 FAM59B 0.63 10.44 0.38 1.16e-23 Gut microbiome composition (summer); BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg09177884 chr7:1199841 ZFAND2A -0.42 -9.02 -0.34 2.15e-18 Longevity;Endometriosis; BRCA cis rs12541635 0.966 rs4416800 chr8:106996677 T/C cg10147462 chr8:107024639 NA 0.37 9.92 0.37 1.19e-21 Age of smoking initiation; BRCA cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.54 -0.32 1.01e-16 Glomerular filtration rate (creatinine); BRCA cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg05347473 chr6:146136440 FBXO30 0.44 8.66 0.32 3.75e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1829883 0.804 rs1608435 chr5:98817492 A/G cg08333243 chr5:99726346 NA -0.36 -8.79 -0.33 1.38e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs7666738 0.830 rs17027198 chr4:98991085 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.33e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg14664628 chr15:75095509 CSK -0.52 -12.15 -0.43 1.03e-30 Breast cancer; BRCA cis rs11718455 0.883 rs4682926 chr3:44006170 C/T cg08738300 chr3:44038990 NA 0.44 8.55 0.32 8.81e-17 Coronary artery disease; BRCA cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg06108461 chr20:60628389 TAF4 -0.85 -16.03 -0.54 7.02e-49 Body mass index; BRCA cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg22496339 chr2:162101262 NA 0.44 9.07 0.34 1.42e-18 Intelligence (multi-trait analysis); BRCA cis rs6750795 0.641 rs10933375 chr2:232367296 A/T cg19187155 chr2:232395269 NMUR1 -0.53 -9.77 -0.36 4.1e-21 Height; BRCA cis rs7917772 0.565 rs61869210 chr10:104437175 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.49 11.84 0.42 2.14e-29 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA cis rs13040088 1.000 rs12480870 chr20:61543606 A/C cg23096297 chr20:61557774 DIDO1 0.89 17.74 0.57 1.41e-57 Menopause (age at onset); BRCA cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg13010199 chr12:38710504 ALG10B 0.58 12.95 0.46 3.27e-34 Heart rate; BRCA cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg03264133 chr6:25882463 NA -0.47 -11.04 -0.4 4.87e-26 Blood metabolite levels; BRCA cis rs7945718 0.875 rs9888178 chr11:12782643 C/T cg25843174 chr11:12811716 TEAD1 0.23 8.88 0.33 6.97e-18 Educational attainment (years of education); BRCA cis rs4363385 0.818 rs61811863 chr1:152995721 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.27 -0.31 7.84e-16 Inflammatory skin disease; BRCA cis rs3768617 0.811 rs12144261 chr1:183014148 A/G ch.1.3577855R chr1:183094577 LAMC1 0.44 9.54 0.35 2.99e-20 Fuchs's corneal dystrophy; BRCA cis rs7618501 0.635 rs7635002 chr3:49989155 T/G cg05623727 chr3:50126028 RBM5 0.41 9.7 0.36 7.36e-21 Intelligence (multi-trait analysis); BRCA cis rs8013055 0.796 rs4075105 chr14:106000231 C/T cg19700328 chr14:106028568 NA -0.44 -9.32 -0.35 1.8e-19 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis); BRCA trans rs7615952 0.575 rs35949599 chr3:125544202 G/A cg07211511 chr3:129823064 LOC729375 -0.78 -14.88 -0.51 3.36e-43 Blood pressure (smoking interaction); BRCA cis rs7267979 1.000 rs2482937 chr20:25340786 A/G cg08601574 chr20:25228251 PYGB -0.38 -9.06 -0.34 1.59e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12142240 0.730 rs56030283 chr1:46823093 C/G cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.34e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg08000102 chr2:233561755 GIGYF2 0.64 13.95 0.48 8.76e-39 Coronary artery disease; BRCA cis rs9393777 0.546 rs9366673 chr6:26893329 C/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -8.08 -0.3 3.25e-15 Intelligence (multi-trait analysis); BRCA trans rs9944715 0.954 rs7231430 chr18:43823472 C/T cg01718231 chr17:29326311 RNF135 0.42 8.49 0.32 1.45e-16 Red cell distribution width;Mean corpuscular volume; BRCA trans rs35110281 0.712 rs167930 chr21:44946625 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.08 0.3 3.19e-15 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.65e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7918232 0.941 rs1753415 chr10:27395102 T/C cg14240646 chr10:27532245 ACBD5 -0.64 -9.36 -0.35 1.38e-19 Breast cancer; BRCA cis rs6444746 1.000 rs6444746 chr3:193495155 A/G cg22553634 chr3:193489233 NA -0.54 -8.55 -0.32 8.83e-17 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); BRCA cis rs941873 0.805 rs876678 chr10:81111036 G/T cg11057378 chr10:81107060 PPIF 0.35 8.48 0.32 1.55e-16 Height; BRCA cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.52 0.41 4.72e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs10028773 0.568 rs6838457 chr4:120267367 A/G cg25214090 chr10:38739885 LOC399744 0.43 10.0 0.37 5.45e-22 Educational attainment; BRCA cis rs67340775 0.541 rs200979 chr6:27852357 G/A cg26587870 chr6:27730563 NA -0.46 -8.12 -0.31 2.35e-15 Lung cancer in ever smokers; BRCA cis rs7178424 0.967 rs17271340 chr15:62347885 C/T cg00456672 chr15:62358751 C2CD4A -0.41 -9.21 -0.34 4.63e-19 Height; BRCA cis rs10129255 0.536 rs17113249 chr14:107134290 A/G cg07958169 chr14:107095056 NA -0.38 -8.17 -0.31 1.72e-15 Kawasaki disease; BRCA cis rs67460515 0.531 rs13060601 chr3:160823159 G/A cg17135325 chr3:160939158 NMD3 0.42 8.06 0.3 3.75e-15 Parkinson's disease; BRCA trans rs9325144 0.534 rs4882283 chr12:38710249 C/T cg23762105 chr12:34175262 ALG10 -0.33 -8.02 -0.3 4.95e-15 Morning vs. evening chronotype; BRCA cis rs3845702 0.736 rs2367990 chr2:180843126 C/T cg01881094 chr2:180872142 CWC22 -1.01 -18.23 -0.58 4.24e-60 Schizophrenia; BRCA cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg08477640 chr19:41863820 B9D2 0.39 8.0 0.3 5.99e-15 Migraine;Coronary artery disease; BRCA cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg06026331 chr20:60912101 LAMA5 0.64 12.37 0.44 1.16e-31 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg10523679 chr1:76189770 ACADM -0.5 -9.83 -0.36 2.48e-21 Daytime sleep phenotypes; BRCA cis rs2479106 0.727 rs10986139 chr9:126689150 C/G cg16191174 chr9:126692580 DENND1A 0.47 8.98 0.33 2.99e-18 Polycystic ovary syndrome; BRCA cis rs765787 0.505 rs12593605 chr15:45497448 T/A cg24006582 chr15:45444508 DUOX1 0.59 11.34 0.41 2.7e-27 Uric acid levels; BRCA cis rs2108225 0.658 rs1476673 chr7:107435945 C/G cg18560240 chr7:107437656 SLC26A3 -0.57 -12.13 -0.43 1.3e-30 Ulcerative colitis; BRCA cis rs7523050 0.908 rs67425757 chr1:109398656 T/G cg08274380 chr1:109419600 GPSM2 0.82 12.7 0.45 4.32e-33 Fat distribution (HIV); BRCA cis rs13108904 0.901 rs7673398 chr4:1300077 G/A cg00684032 chr4:1343700 KIAA1530 0.31 8.0 0.3 5.76e-15 Obesity-related traits; BRCA cis rs6570726 0.738 rs4495284 chr6:145916617 T/A cg05347473 chr6:146136440 FBXO30 0.42 8.37 0.31 3.57e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7020830 0.867 rs56098516 chr9:37362220 A/G cg14294708 chr9:37120828 ZCCHC7 1.12 36.29 0.82 2.38e-157 Schizophrenia; BRCA trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.12 0.34 9.85e-19 Morning vs. evening chronotype; BRCA cis rs2882667 0.690 rs9327828 chr5:138261548 T/G cg04439458 chr5:138467593 SIL1 -0.35 -8.54 -0.32 9.54e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 -0.54 -8.6 -0.32 6.35e-17 Lung function (FEV1/FVC); BRCA cis rs7103648 0.897 rs3758675 chr11:47400602 G/A cg03711944 chr11:47377212 SPI1 -0.5 -12.52 -0.44 2.51e-32 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg00339695 chr16:24857497 SLC5A11 0.34 8.04 0.3 4.31e-15 Intelligence (multi-trait analysis); BRCA cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg25588852 chr2:216877276 MREG -0.28 -7.98 -0.3 6.76e-15 Alcohol dependence; BRCA cis rs7737355 0.947 rs32115 chr5:131051328 A/G cg06307176 chr5:131281290 NA 0.48 9.34 0.35 1.55e-19 Life satisfaction; BRCA cis rs7072216 0.727 rs942807 chr10:100168219 G/A cg26618903 chr10:100175079 PYROXD2 -0.31 -8.96 -0.33 3.58e-18 Metabolite levels; BRCA cis rs2204008 0.576 rs11519979 chr12:37999413 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.09 0.56 3.19e-54 Bladder cancer; BRCA cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg13660082 chr14:53194042 PSMC6 -0.58 -8.63 -0.32 4.8e-17 Alzheimer's disease (late onset); BRCA cis rs9649213 0.574 rs13238610 chr7:97909277 T/C cg21770322 chr7:97807741 LMTK2 0.41 10.94 0.4 1.14e-25 Prostate cancer (SNP x SNP interaction); BRCA trans rs8073060 0.521 rs225254 chr17:33953384 G/A cg19694781 chr19:47549865 TMEM160 -0.46 -10.75 -0.39 6.98e-25 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs11098499 0.615 rs28850368 chr4:120554313 G/A cg09307838 chr4:120376055 NA 0.6 12.42 0.44 7.18e-32 Corneal astigmatism; BRCA cis rs10267417 0.603 rs12669215 chr7:19933427 C/T cg05791153 chr7:19748676 TWISTNB 0.43 8.09 0.3 3.01e-15 Night sleep phenotypes; BRCA cis rs7584330 0.554 rs6760890 chr2:238400645 G/A cg08992911 chr2:238395768 MLPH 0.59 10.18 0.37 1.18e-22 Prostate cancer; BRCA cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg06636001 chr8:8085503 FLJ10661 -0.55 -12.09 -0.43 1.93e-30 Mood instability; BRCA cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg13852791 chr20:30311386 BCL2L1 0.86 16.88 0.56 3.89e-53 Mean corpuscular hemoglobin; BRCA cis rs17401966 0.838 rs34565762 chr1:10300119 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.95 0.48 8.64e-39 Hepatocellular carcinoma; BRCA cis rs765787 0.530 rs7165889 chr15:45531640 T/C cg24006582 chr15:45444508 DUOX1 -0.54 -11.07 -0.4 3.42e-26 Uric acid levels; BRCA cis rs853679 0.517 rs6922063 chr6:28094366 G/A cg18032046 chr6:28092343 ZSCAN16 -0.49 -7.96 -0.3 7.64e-15 Depression; BRCA cis rs11105298 0.891 rs10858879 chr12:89886578 A/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.59 10.1 0.37 2.31e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg11663144 chr21:46675770 NA -0.49 -9.78 -0.36 3.89e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs698833 0.828 rs2850298 chr2:44731590 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.03 0.37 4.52e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg24549020 chr5:56110836 MAP3K1 0.6 12.38 0.44 1.03e-31 Initial pursuit acceleration; BRCA cis rs2463822 1.000 rs72921498 chr11:62113090 C/T cg06239285 chr11:62104954 ASRGL1 -0.68 -11.38 -0.41 1.93e-27 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7617773 0.746 rs6796343 chr3:48282021 C/A cg11946769 chr3:48343235 NME6 0.67 13.88 0.48 1.83e-38 Coronary artery disease; BRCA cis rs17253792 0.822 rs10143002 chr14:56074278 G/A cg01858014 chr14:56050164 KTN1 -0.78 -10.6 -0.39 2.74e-24 Putamen volume; BRCA cis rs7833986 1.000 rs13273123 chr8:57100791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 -0.45 -8.14 -0.31 2.13e-15 Height; BRCA cis rs16866061 0.515 rs114968850 chr2:225352461 C/G cg12698349 chr2:225449008 CUL3 0.84 29.39 0.76 8.89e-121 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg12564285 chr5:131593104 PDLIM4 0.36 9.83 0.36 2.57e-21 Breast cancer; BRCA cis rs7267979 0.932 rs424487 chr20:25468131 C/G cg08601574 chr20:25228251 PYGB 0.34 8.16 0.31 1.79e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg19626725 chr5:178986131 RUFY1 0.31 8.43 0.32 2.3e-16 Lung cancer; BRCA cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg27398817 chr8:82754497 SNX16 -0.48 -9.14 -0.34 8.31e-19 Diastolic blood pressure; BRCA cis rs12701220 0.522 rs12701455 chr7:1055409 A/G cg04025307 chr7:1156635 C7orf50 0.46 10.35 0.38 2.66e-23 Bronchopulmonary dysplasia; BRCA trans rs61931739 0.517 rs1843735 chr12:34047389 C/G cg26384229 chr12:38710491 ALG10B 0.51 11.13 0.4 1.95e-26 Morning vs. evening chronotype; BRCA cis rs9653442 0.648 rs6733895 chr2:100666082 C/G cg22139774 chr2:100720529 AFF3 -0.28 -7.99 -0.3 6.2e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22455342 chr2:225449267 CUL3 0.65 17.09 0.56 3.49e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg01483505 chr11:975446 AP2A2 0.3 8.09 0.3 2.97e-15 Alzheimer's disease (late onset); BRCA cis rs1401999 0.966 rs4148585 chr3:183670642 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.08 0.37 2.78e-22 Anterior chamber depth; BRCA cis rs2762353 0.808 rs1185569 chr6:25831603 A/G cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg18446336 chr7:2847575 GNA12 -0.35 -8.3 -0.31 6.39e-16 Height; BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg24633833 chr3:10029261 TMEM111 0.41 7.96 0.3 8.17e-15 Alzheimer's disease; BRCA cis rs7618501 0.601 rs2624825 chr3:50154989 G/A cg05623727 chr3:50126028 RBM5 -0.42 -10.07 -0.37 3.02e-22 Intelligence (multi-trait analysis); BRCA cis rs7917772 0.582 rs10883753 chr10:104372441 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.3 0.49 1.82e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg24838063 chr12:130822603 PIWIL1 0.67 16.36 0.54 1.6e-50 Menopause (age at onset); BRCA cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.47 0.41 7.88e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2255932 1.000 rs11075 chr3:183213236 G/A cg12326526 chr3:183209927 KLHL6 0.46 7.81 0.3 2.44e-14 Interleukin-1-beta levels; BRCA cis rs4481887 0.927 rs4244185 chr1:248486913 A/G cg13385794 chr1:248469461 NA 0.27 7.89 0.3 1.32e-14 Common traits (Other); BRCA trans rs9291683 0.566 rs13144709 chr4:10044182 C/T cg26043149 chr18:55253948 FECH 0.4 8.71 0.33 2.66e-17 Bone mineral density; BRCA cis rs7011049 1.000 rs72640852 chr8:53838084 G/A cg26025543 chr8:53854495 NA 0.55 9.64 0.36 1.25e-20 Systolic blood pressure; BRCA cis rs11608355 0.515 rs2287191 chr12:109931741 C/T cg05360138 chr12:110035743 NA 0.74 13.68 0.48 1.56e-37 Neuroticism; BRCA cis rs738322 0.555 rs2284063 chr22:38544298 C/T cg20207973 chr22:38506712 BAIAP2L2 -0.33 -8.16 -0.31 1.78e-15 Cutaneous nevi; BRCA cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg08917208 chr2:24149416 ATAD2B 0.52 8.07 0.3 3.37e-15 Lymphocyte counts; BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00166722 chr3:10149974 C3orf24 0.67 13.44 0.47 1.83e-36 Alzheimer's disease; BRCA cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.52 9.91 0.37 1.2e-21 Lung cancer in ever smokers; BRCA cis rs17253792 0.545 rs35294669 chr14:56017438 T/A cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs6120849 0.901 rs11696967 chr20:33743609 A/C cg24642439 chr20:33292090 TP53INP2 0.48 8.51 0.32 1.2e-16 Protein C levels; BRCA cis rs6964587 1.000 rs11772102 chr7:91558326 A/T cg17063962 chr7:91808500 NA -0.52 -12.15 -0.43 1e-30 Breast cancer; BRCA cis rs7394190 0.748 rs3781216 chr10:75522404 G/A cg07699608 chr10:75541558 CHCHD1 0.66 9.9 0.36 1.34e-21 Incident atrial fibrillation; BRCA cis rs10465746 0.570 rs2147950 chr1:84465545 C/T cg10977910 chr1:84465055 TTLL7 0.54 11.15 0.4 1.72e-26 Obesity-related traits; BRCA cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg00825309 chr19:58991885 ZNF446 -0.64 -14.27 -0.49 2.53e-40 Uric acid clearance; BRCA trans rs8073060 0.544 rs7211724 chr17:33993414 C/G cg19694781 chr19:47549865 TMEM160 -1.05 -22.33 -0.66 4.41e-82 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs35146811 0.660 rs3779046 chr7:99779243 A/G cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs3820928 0.874 rs6706802 chr2:227850776 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -8.79 -0.33 1.35e-17 Pulmonary function; BRCA cis rs10197940 0.510 rs7602715 chr2:152421937 A/G cg06191203 chr2:152266755 RIF1 -0.33 -9.08 -0.34 1.29e-18 Lung cancer; BRCA cis rs13064411 0.542 rs7631335 chr3:113209166 C/T cg18753928 chr3:113234510 CCDC52 -0.46 -9.92 -0.37 1.14e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs926392 0.572 rs6129158 chr20:37673967 A/G cg16355469 chr20:37678765 NA 0.49 11.78 0.42 3.81e-29 Dialysis-related mortality; BRCA cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg13010199 chr12:38710504 ALG10B 0.45 9.09 0.34 1.19e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs17818399 0.547 rs7607308 chr2:46759104 T/C cg02822958 chr2:46747628 ATP6V1E2 0.58 11.01 0.4 6.48e-26 Height; BRCA cis rs4889855 0.530 rs62068346 chr17:78608052 A/G cg16591659 chr17:78472290 NA -0.31 -7.9 -0.3 1.23e-14 Fractional excretion of uric acid; BRCA cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg27129171 chr3:47204927 SETD2 0.65 14.72 0.5 1.87e-42 Colorectal cancer; BRCA cis rs7607369 0.782 rs639913 chr2:219365971 A/C cg10223061 chr2:219282414 VIL1 -0.27 -7.83 -0.3 2.02e-14 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs113835537 0.529 rs10896125 chr11:66288733 G/C cg24851651 chr11:66362959 CCS 0.43 8.16 0.31 1.78e-15 Airway imaging phenotypes; BRCA cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg03477792 chr4:77819574 ANKRD56 0.62 15.03 0.51 5.79e-44 Emphysema distribution in smoking; BRCA cis rs9858542 0.953 rs7633271 chr3:49555963 T/C cg07274523 chr3:49395745 GPX1 0.45 7.94 0.3 8.82e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg00071950 chr4:10020882 SLC2A9 0.57 13.88 0.48 1.78e-38 Bone mineral density; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg05863683 chr7:1912471 MAD1L1 0.38 8.41 0.32 2.77e-16 Bipolar disorder and schizophrenia; BRCA cis rs796364 0.906 rs281766 chr2:200820505 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.72 12.01 0.43 4.39e-30 Schizophrenia; BRCA cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.65 16.8 0.55 9.85e-53 Colorectal cancer; BRCA cis rs586533 0.881 rs655715 chr11:99500369 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs12681288 0.676 rs2701913 chr8:999982 A/T cg04851639 chr8:1020857 NA -0.38 -10.97 -0.4 8.81e-26 Schizophrenia; BRCA cis rs5167 0.504 rs7257476 chr19:45453165 C/T cg09555818 chr19:45449301 APOC2 0.47 12.22 0.44 5.19e-31 Blood protein levels; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg05457628 chr5:178986728 RUFY1 0.41 9.36 0.35 1.36e-19 Lung cancer; BRCA cis rs4919694 0.901 rs12264456 chr10:104830634 C/T cg04362960 chr10:104952993 NT5C2 0.94 14.66 0.5 3.75e-42 Arsenic metabolism; BRCA cis rs7264396 1.000 rs224430 chr20:34153341 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.46 -9.96 -0.37 8.39e-22 Total cholesterol levels; BRCA cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.97 0.51 1.25e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4908760 0.827 rs1463053 chr1:8705037 C/T cg20416874 chr1:8611966 RERE -0.27 -7.96 -0.3 7.68e-15 Vitiligo; BRCA cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.37 -0.31 3.54e-16 Bipolar disorder; BRCA cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg13736514 chr6:26305472 NA -0.29 -9.67 -0.36 9.42e-21 Educational attainment; BRCA cis rs61931739 0.534 rs11052983 chr12:34045787 C/A cg06521331 chr12:34319734 NA -0.63 -12.21 -0.43 5.84e-31 Morning vs. evening chronotype; BRCA cis rs12618769 0.597 rs72820002 chr2:99075259 T/A cg10123293 chr2:99228465 UNC50 0.41 8.27 0.31 8.05e-16 Bipolar disorder; BRCA cis rs1865721 0.771 rs4622605 chr18:73139008 T/C cg26385618 chr18:73139727 C18orf62 -0.44 -10.78 -0.39 5.22e-25 Intelligence; BRCA cis rs13102973 0.932 rs13149380 chr4:135866539 A/C cg14419869 chr4:135874104 NA 0.51 10.97 0.4 9.38e-26 Subjective well-being; BRCA cis rs7474896 0.832 rs12357256 chr10:38359501 A/G cg25427524 chr10:38739819 LOC399744 -0.59 -8.11 -0.31 2.59e-15 Obesity (extreme); BRCA cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.19 -0.31 1.44e-15 Bipolar disorder; BRCA cis rs2979489 0.786 rs62508366 chr8:30369499 G/A cg26383811 chr8:30366931 RBPMS -0.56 -12.83 -0.45 1.07e-33 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA trans rs1973993 0.745 rs986427 chr1:96932736 A/G cg10631902 chr5:14652156 NA -0.49 -14.0 -0.48 4.75e-39 Weight; BRCA cis rs796364 0.774 rs112564437 chr2:201074048 G/C cg17644776 chr2:200775616 C2orf69 -0.46 -8.67 -0.32 3.61e-17 Schizophrenia; BRCA cis rs4642101 0.662 rs1969154 chr3:12829156 A/G cg24848339 chr3:12840334 CAND2 0.46 12.16 0.43 9.01e-31 QRS complex (12-leadsum); BRCA cis rs1784581 0.894 rs1790001 chr6:162387504 G/T cg17173639 chr6:162384350 PARK2 -0.47 -11.42 -0.41 1.23e-27 Itch intensity from mosquito bite; BRCA cis rs2762353 0.603 rs9393670 chr6:25789061 A/G cg03517284 chr6:25882590 NA 0.36 7.98 0.3 6.82e-15 Blood metabolite levels; BRCA cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg22972055 chr7:872293 UNC84A 0.38 8.63 0.32 4.83e-17 Cerebrospinal P-tau181p levels; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs1506636 0.962 rs1019220 chr7:123365122 G/A cg03229431 chr7:123269106 ASB15 -0.61 -13.77 -0.48 5.52e-38 Plateletcrit;Platelet count; BRCA cis rs8016982 0.674 rs1951614 chr14:81672106 A/G cg01989461 chr14:81687754 GTF2A1 -0.71 -16.3 -0.54 3.23e-50 Schizophrenia; BRCA cis rs7818345 1.000 rs4618712 chr8:19302621 A/G cg11303988 chr8:19266685 CSGALNACT1 0.32 8.32 0.31 5.4e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs477692 1.000 rs506274 chr10:131409392 T/A cg05714579 chr10:131428358 MGMT 0.54 12.77 0.45 2.09e-33 Response to temozolomide; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.89 -0.33 6.07e-18 Total body bone mineral density; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg04234412 chr22:24373322 LOC391322 0.56 13.22 0.46 1.98e-35 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg22834771 chr12:69754056 YEATS4 -0.37 -9.05 -0.34 1.69e-18 Blood protein levels; BRCA cis rs7582180 0.764 rs11689439 chr2:100925399 T/C cg14675211 chr2:100938903 LONRF2 0.49 11.18 0.4 1.22e-26 Intelligence (multi-trait analysis); BRCA trans rs17685 0.735 rs11763339 chr7:75761541 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7267979 1.000 rs7343481 chr20:25300113 C/T cg08601574 chr20:25228251 PYGB -0.36 -8.56 -0.32 8.44e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs9944715 0.734 rs9967220 chr18:43780059 C/T cg01718231 chr17:29326311 RNF135 -0.46 -9.07 -0.34 1.44e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs10751667 1.000 rs12798036 chr11:947585 T/C cg10932868 chr11:921992 NA 0.39 9.6 0.35 1.84e-20 Alzheimer's disease (late onset); BRCA cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.76e-18 Motion sickness; BRCA cis rs2304069 0.954 rs4705408 chr5:149412545 A/G cg12661370 chr5:149340060 SLC26A2 -0.58 -8.46 -0.32 1.8e-16 HIV-1 control; BRCA cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg21573476 chr21:45109991 RRP1B -0.37 -9.55 -0.35 2.71e-20 Mean corpuscular volume; BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg27170947 chr2:26402098 FAM59B -1.0 -17.53 -0.57 1.82e-56 Gut microbiome composition (summer); BRCA cis rs1215050 0.791 rs13107606 chr4:98823187 C/A cg05340658 chr4:99064831 C4orf37 0.46 10.63 0.39 2.06e-24 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.89 0.3 1.33e-14 Corneal astigmatism; BRCA cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.33 0.35 1.64e-19 Rheumatoid arthritis; BRCA cis rs2625529 0.824 rs11072338 chr15:72245447 T/C cg16672083 chr15:72433130 SENP8 -0.84 -17.52 -0.57 2.13e-56 Red blood cell count; BRCA trans rs11098499 0.780 rs12504773 chr4:120562149 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.34 0.31 4.69e-16 Corneal astigmatism; BRCA cis rs7524258 0.778 rs12028181 chr1:7315085 C/T cg07173049 chr1:7289937 CAMTA1 -0.4 -9.89 -0.36 1.48e-21 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs7772486 0.754 rs2328707 chr6:146053498 G/A cg23711669 chr6:146136114 FBXO30 -0.78 -18.82 -0.6 3.19e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs2439831 0.850 rs7174208 chr15:44052682 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.82 0.36 2.79e-21 Lung cancer in ever smokers; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg02951883 chr7:2050386 MAD1L1 -0.62 -15.52 -0.52 2.57e-46 Bipolar disorder and schizophrenia; BRCA cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg22467129 chr15:76604101 ETFA -0.5 -10.91 -0.4 1.64e-25 Blood metabolite levels; BRCA cis rs6942756 1.000 rs67820265 chr7:128887925 A/G cg02491457 chr7:128862824 NA -0.71 -14.06 -0.49 2.64e-39 White matter hyperintensity burden; BRCA cis rs1941023 0.567 rs955019 chr11:60174250 C/T cg08716584 chr11:60157161 MS4A7 -0.34 -8.01 -0.3 5.33e-15 Congenital heart disease (maternal effect); BRCA cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg24060327 chr5:131705240 SLC22A5 -0.62 -11.87 -0.43 1.63e-29 Breast cancer; BRCA cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg21138405 chr5:131827807 IRF1 0.38 12.38 0.44 1.01e-31 Asthma (sex interaction); BRCA cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg14844989 chr11:31128820 NA -0.45 -9.65 -0.36 1.14e-20 Red blood cell count; BRCA cis rs11971779 0.680 rs7801613 chr7:139039927 A/G cg07862535 chr7:139043722 LUC7L2 -0.4 -10.78 -0.39 5.41e-25 Diisocyanate-induced asthma; BRCA cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.58 -0.32 7.39e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs11955398 0.563 rs7730342 chr5:60020645 G/T cg02684056 chr5:59996105 DEPDC1B -0.37 -9.0 -0.34 2.58e-18 Intelligence (multi-trait analysis); BRCA cis rs11971779 0.941 rs4732368 chr7:139034207 A/C cg07862535 chr7:139043722 LUC7L2 0.53 12.94 0.46 3.33e-34 Diisocyanate-induced asthma; BRCA cis rs243505 0.732 rs3800949 chr7:148479648 A/T cg09806900 chr7:148480153 CUL1 -0.5 -10.44 -0.38 1.1e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.1 0.4 2.68e-26 Bipolar disorder; BRCA cis rs6701037 0.566 rs10753091 chr1:175134571 T/C cg00321850 chr1:175162397 KIAA0040 0.43 12.38 0.44 1.05e-31 Alcohol dependence; BRCA cis rs780096 0.545 rs2280737 chr2:27589810 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.13 -0.31 2.23e-15 Total body bone mineral density; BRCA cis rs4285028 0.948 rs7640872 chr3:121697168 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.41 -0.38 1.49e-23 Multiple sclerosis; BRCA cis rs9633740 0.545 rs2343306 chr10:82230146 A/G cg00277334 chr10:82204260 NA 0.49 8.66 0.32 3.73e-17 Post bronchodilator FEV1; BRCA cis rs7264396 0.563 rs1970577 chr20:34336737 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.91 -0.43 1.13e-29 Total cholesterol levels; BRCA cis rs9467773 1.000 rs6456734 chr6:26566965 G/T cg09904177 chr6:26538194 HMGN4 0.55 17.71 0.57 2.12e-57 Intelligence (multi-trait analysis); BRCA cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg24642439 chr20:33292090 TP53INP2 0.7 15.65 0.53 5.93e-47 Coronary artery disease; BRCA cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg23205692 chr1:25664452 TMEM50A 0.41 9.86 0.36 1.87e-21 Erythrocyte sedimentation rate; BRCA cis rs10779751 0.708 rs2746640 chr1:11292952 T/A cg08854313 chr1:11322531 MTOR 0.77 15.8 0.53 1.06e-47 Body mass index; BRCA cis rs9309473 0.687 rs6748040 chr2:73609928 A/G cg20560298 chr2:73613845 ALMS1 0.46 12.09 0.43 1.99e-30 Metabolite levels; BRCA cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.88 -0.33 6.76e-18 Developmental language disorder (linguistic errors); BRCA cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg24675658 chr1:53192096 ZYG11B -0.53 -11.19 -0.4 1.13e-26 Monocyte count; BRCA cis rs8040855 0.825 rs3964197 chr15:85721912 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.33 -8.3 -0.31 6.1e-16 Bulimia nervosa; BRCA trans rs561341 0.714 rs111760509 chr17:30304320 A/G cg20587970 chr11:113659929 NA -1.2 -21.93 -0.66 6.74e-80 Hip circumference adjusted for BMI; BRCA cis rs367615 0.918 rs10070104 chr5:108866438 C/T cg17395555 chr5:108820864 NA -0.38 -9.86 -0.36 1.96e-21 Colorectal cancer (SNP x SNP interaction); BRCA cis rs2712184 0.655 rs1003622 chr2:217653608 A/G cg05032264 chr2:217675019 NA -0.38 -9.08 -0.34 1.34e-18 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA trans rs7980799 0.682 rs1384599 chr12:33624579 G/A cg26384229 chr12:38710491 ALG10B -0.51 -10.97 -0.4 8.96e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs7586879 0.828 rs1865688 chr2:25108245 C/G cg04586622 chr2:25135609 ADCY3 0.39 9.39 0.35 1e-19 Body mass index; BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.08 0.34 1.38e-18 Platelet count; BRCA cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg10820045 chr2:198174542 NA -0.42 -9.6 -0.36 1.75e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1707322 1.000 rs4390216 chr1:46266456 C/T cg03146154 chr1:46216737 IPP 0.46 10.03 0.37 4.21e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs858239 0.600 rs7790157 chr7:23126998 G/A cg23682824 chr7:23144976 KLHL7 0.45 12.21 0.44 5.48e-31 Cerebrospinal fluid biomarker levels; BRCA trans rs11098499 0.909 rs10026736 chr4:120384322 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.03 0.3 4.69e-15 Corneal astigmatism; BRCA trans rs3733585 0.699 rs57574512 chr4:9960182 T/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs147858478 1 rs147858478 chr5:131682785 CCTGAGTT/C cg24060327 chr5:131705240 SLC22A5 -0.49 -10.21 -0.37 8.98e-23 High light scatter reticulocyte percentage of red cells; BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg00106254 chr7:1943704 MAD1L1 -0.4 -9.62 -0.36 1.49e-20 Bipolar disorder and schizophrenia; BRCA cis rs7394190 0.748 rs16930909 chr10:75561582 T/C cg07699608 chr10:75541558 CHCHD1 0.67 10.11 0.37 2.24e-22 Incident atrial fibrillation; BRCA cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg06636001 chr8:8085503 FLJ10661 0.44 8.13 0.31 2.18e-15 Obesity-related traits; BRCA cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.49 0.5 2.35e-41 Motion sickness; BRCA cis rs6500602 0.627 rs860891 chr16:4586529 C/T cg08645402 chr16:4508243 NA -0.4 -9.52 -0.35 3.53e-20 Schizophrenia; BRCA cis rs8062405 1.000 rs12444171 chr16:28845251 G/A cg16576597 chr16:28551801 NUPR1 0.3 8.37 0.31 3.53e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11098499 0.863 rs12498539 chr4:120468370 C/T cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg20887711 chr4:1340912 KIAA1530 0.72 15.76 0.53 1.72e-47 Longevity; BRCA cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.67 15.19 0.52 9.84e-45 Axial length; BRCA cis rs9527 0.590 rs11191513 chr10:104772984 T/G cg04362960 chr10:104952993 NT5C2 0.44 9.95 0.37 8.74e-22 Arsenic metabolism; BRCA cis rs2832191 0.755 rs2832193 chr21:30493589 T/C cg24692254 chr21:30365293 RNF160 -0.63 -16.19 -0.54 1.22e-49 Dental caries; BRCA cis rs4363385 0.782 rs4845336 chr1:153003853 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.08 -0.34 1.39e-18 Inflammatory skin disease; BRCA cis rs72772090 0.710 rs17400685 chr5:96066366 A/C cg17330273 chr5:96107758 CAST;ERAP1 0.6 12.98 0.46 2.4e-34 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg08470875 chr2:26401718 FAM59B 0.77 11.93 0.43 8.92e-30 Gut microbiome composition (summer); BRCA trans rs9951602 0.512 rs1599633 chr18:76643526 T/C cg02800362 chr5:177631904 HNRNPAB 0.76 17.5 0.57 2.47e-56 Obesity-related traits; BRCA cis rs7555523 0.943 rs4537525 chr1:165711089 T/G cg24409356 chr1:165738333 TMCO1 0.51 8.21 0.31 1.23e-15 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.42 0.66 1.4e-82 Platelet count; BRCA cis rs4363385 0.747 rs1577962 chr1:152962013 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.35 -0.35 1.4e-19 Inflammatory skin disease; BRCA cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs501916 0.634 rs3803349 chr15:48064867 T/A cg16110827 chr15:48056943 SEMA6D -0.42 -8.82 -0.33 1.08e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg02820040 chr2:241836501 C2orf54 -0.51 -9.57 -0.35 2.34e-20 Urinary metabolites; BRCA cis rs4906332 1.000 rs4900574 chr14:103879024 G/A cg26031613 chr14:104095156 KLC1 0.44 8.38 0.31 3.36e-16 Coronary artery disease; BRCA cis rs11190604 1.000 rs12355721 chr10:102244911 C/T cg07080220 chr10:102295463 HIF1AN 0.52 11.45 0.41 9.33e-28 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.77 0.67 1.63e-84 Chronic sinus infection; BRCA trans rs79976124 0.879 rs17432710 chr6:66621744 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.61 10.77 0.39 5.59e-25 Type 2 diabetes; BRCA cis rs4819052 0.807 rs7283915 chr21:46671288 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.93 0.33 4.64e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg16414030 chr3:133502952 NA 0.5 11.89 0.43 1.32e-29 Iron status biomarkers; BRCA trans rs7824557 0.724 rs2572398 chr8:11178093 A/C cg15556689 chr8:8085844 FLJ10661 0.42 11.31 0.41 3.78e-27 Retinal vascular caliber; BRCA trans rs61931739 0.513 rs1608908 chr12:33895389 C/A cg13010199 chr12:38710504 ALG10B 0.37 8.21 0.31 1.24e-15 Morning vs. evening chronotype; BRCA cis rs9457247 0.663 rs1894603 chr6:167434686 C/T cg07741184 chr6:167504864 NA -0.27 -7.96 -0.3 7.62e-15 Crohn's disease; BRCA trans rs7615952 0.599 rs67566088 chr3:125768973 C/A cg07211511 chr3:129823064 LOC729375 -0.63 -11.05 -0.4 4.13e-26 Blood pressure (smoking interaction); BRCA cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg06046430 chr4:77819534 ANKRD56 0.58 13.14 0.46 4.56e-35 Emphysema distribution in smoking; BRCA cis rs3760982 0.585 rs67704568 chr19:44294019 T/C cg12072164 chr19:44306565 LYPD5 0.37 8.67 0.32 3.46e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs10045504 0.502 rs57589709 chr5:38733853 C/T cg15396434 chr5:38725168 NA -0.59 -11.11 -0.4 2.41e-26 Night sleep phenotypes; BRCA cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg08280861 chr8:58055591 NA 0.54 8.66 0.32 3.79e-17 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg06618935 chr21:46677482 NA -0.38 -8.45 -0.32 1.89e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs61656020 1 rs61656020 chr16:1882221 C/G cg26897989 chr16:1907736 C16orf73 -0.52 -9.58 -0.35 2.04e-20 Ankle injury; BRCA trans rs931812 0.895 rs13251731 chr8:101902528 C/G cg20993868 chr7:22813445 NA 0.55 16.25 0.54 5.7e-50 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg18964960 chr10:1102726 WDR37 0.59 7.86 0.3 1.66e-14 Eosinophil percentage of granulocytes; BRCA cis rs7590720 1.000 rs934156 chr2:216901482 C/T cg12620499 chr2:216877984 MREG -0.78 -21.0 -0.64 7.6e-75 Alcohol dependence; BRCA cis rs7191439 0.657 rs3826076 chr16:88780518 C/T cg27087555 chr16:88793112 FAM38A 0.74 11.03 0.4 5.37e-26 Plateletcrit; BRCA cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg08999081 chr20:33150536 PIGU -0.46 -12.77 -0.45 2.05e-33 Glomerular filtration rate (creatinine); BRCA cis rs7833790 0.724 rs72603871 chr8:82754460 C/G cg27398817 chr8:82754497 SNX16 0.36 8.17 0.31 1.69e-15 Diastolic blood pressure; BRCA trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg03929089 chr4:120376271 NA 0.47 7.95 0.3 8.43e-15 Axial length; BRCA cis rs1005224 0.889 rs9323617 chr14:76158638 A/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.19 -0.31 1.45e-15 Large artery stroke; BRCA cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.28 0.61 1.2e-65 Smoking behavior; BRCA cis rs6570726 0.791 rs365747 chr6:145866784 C/T cg23711669 chr6:146136114 FBXO30 0.79 18.88 0.6 1.64e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs7786877 0.723 rs6969697 chr7:100209604 G/A cg20848291 chr7:100343083 ZAN -0.58 -10.7 -0.39 1.09e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg08645402 chr16:4508243 NA 0.43 9.71 0.36 7.11e-21 Schizophrenia; BRCA cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg14004847 chr7:1930337 MAD1L1 -0.43 -8.75 -0.33 1.93e-17 Bipolar disorder and schizophrenia; BRCA trans rs1493916 1.000 rs1493916 chr18:31392577 T/G cg15819921 chr19:927150 ARID3A -0.47 -9.04 -0.34 1.84e-18 Life satisfaction; BRCA cis rs7555523 0.887 rs4657471 chr1:165686873 T/C cg24409356 chr1:165738333 TMCO1 0.53 8.4 0.32 2.88e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs72781680 1.000 rs74704838 chr2:24158270 C/A cg08917208 chr2:24149416 ATAD2B 0.94 14.06 0.49 2.61e-39 Lymphocyte counts; BRCA cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg22875332 chr1:76189707 ACADM -0.48 -9.13 -0.34 9.22e-19 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg22907277 chr7:1156413 C7orf50 0.38 8.46 0.32 1.76e-16 Longevity;Endometriosis; BRCA cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg02196655 chr2:10830764 NOL10 0.3 8.15 0.31 1.96e-15 Prostate cancer; BRCA cis rs7662987 0.517 rs2851265 chr4:100029684 A/G cg12011299 chr4:100065546 ADH4 0.48 10.93 0.4 1.34e-25 Smoking initiation; BRCA cis rs7246657 0.943 rs2112923 chr19:37940327 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.45 0.35 6.34e-20 Coronary artery calcification; BRCA cis rs7809950 1.000 rs10258385 chr7:107243350 T/C cg23024343 chr7:107201750 COG5 0.42 9.1 0.34 1.15e-18 Coronary artery disease; BRCA cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg12927641 chr6:109611667 NA -0.42 -10.7 -0.39 1.06e-24 Reticulocyte fraction of red cells; BRCA cis rs6500602 0.627 rs709632 chr16:4587811 C/G cg08645402 chr16:4508243 NA -0.37 -8.86 -0.33 7.59e-18 Schizophrenia; BRCA cis rs933688 1.000 rs889213 chr5:90682151 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 15.63 0.53 7.54e-47 Smoking behavior; BRCA cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg22800045 chr5:56110881 MAP3K1 0.55 10.46 0.38 9.49e-24 Initial pursuit acceleration; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18765753 chr7:1198926 ZFAND2A -0.49 -12.05 -0.43 2.92e-30 Longevity;Endometriosis; BRCA cis rs9467773 0.620 rs2494694 chr6:26619328 A/T cg11502198 chr6:26597334 ABT1 0.57 12.09 0.43 1.82e-30 Intelligence (multi-trait analysis); BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg18758796 chr5:131593413 PDLIM4 0.33 8.85 0.33 8.25e-18 Breast cancer; BRCA cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg02574844 chr11:5959923 NA 0.38 8.16 0.31 1.84e-15 DNA methylation (variation); BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg18402987 chr7:1209562 NA 0.52 9.45 0.35 6.36e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.57 -0.39 3.68e-24 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg00814883 chr7:100076585 TSC22D4 -0.49 -9.64 -0.36 1.26e-20 Platelet count; BRCA cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg00677455 chr12:58241039 CTDSP2 0.47 11.51 0.41 5.58e-28 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg22875332 chr1:76189707 ACADM 0.61 11.52 0.41 4.96e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg05535760 chr7:792225 HEATR2 0.72 13.12 0.46 5.64e-35 Cerebrospinal P-tau181p levels; BRCA cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.45 -10.15 -0.37 1.59e-22 Personality dimensions; BRCA cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs896854 0.653 rs13266313 chr8:95975302 C/T cg26343298 chr8:95960752 TP53INP1 0.3 8.74 0.33 2.07e-17 Type 2 diabetes; BRCA cis rs7646881 1.000 rs61558956 chr3:158452655 T/A cg19483011 chr3:158453295 NA -0.41 -8.08 -0.3 3.34e-15 Tetralogy of Fallot; BRCA cis rs6867032 1.000 rs16902318 chr5:2013568 A/G cg26168224 chr5:2018326 NA 0.64 17.98 0.58 8.6e-59 Gut microbiome composition (winter); BRCA cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs243505 0.559 rs7802887 chr7:148494758 C/T cg09806900 chr7:148480153 CUL1 0.54 11.04 0.4 4.81e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2276314 1.000 rs16967317 chr18:33573400 A/G cg19628046 chr18:33552617 C18orf21 0.59 12.12 0.43 1.44e-30 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2963155 0.518 rs853184 chr5:142640901 C/T cg17617527 chr5:142782415 NR3C1 0.51 7.81 0.3 2.37e-14 Breast cancer; BRCA cis rs7523273 0.606 rs859706 chr1:207962270 G/A cg22525895 chr1:207977042 MIR29B2 -0.51 -12.9 -0.45 5.23e-34 Schizophrenia; BRCA trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg11707556 chr5:10655725 ANKRD33B 0.36 8.51 0.32 1.2e-16 Coronary artery disease; BRCA cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg11366901 chr6:160182831 ACAT2 0.8 15.57 0.52 1.41e-46 Age-related macular degeneration (geographic atrophy); BRCA trans rs61931739 0.534 rs10844729 chr12:34022919 A/G cg13010199 chr12:38710504 ALG10B 0.47 9.04 0.34 1.78e-18 Morning vs. evening chronotype; BRCA cis rs2859741 0.608 rs532719 chr1:37477380 C/T cg09363841 chr1:37513479 NA 0.51 10.93 0.4 1.26e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg03929089 chr4:120376271 NA 0.78 18.17 0.58 8.47e-60 Height; BRCA trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg17470723 chr8:74884337 TCEB1 0.4 8.58 0.32 6.98e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs752010 0.806 rs10890148 chr1:42091517 T/C cg06885757 chr1:42089581 HIVEP3 0.28 10.28 0.38 4.88e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9287719 0.649 rs10175884 chr2:10718534 C/T cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.62e-19 Prostate cancer; BRCA cis rs1005277 0.505 rs200935 chr10:38132810 T/A cg25427524 chr10:38739819 LOC399744 -0.65 -15.66 -0.53 5.3e-47 Extrinsic epigenetic age acceleration; BRCA cis rs7408868 1.000 rs10416389 chr19:15278674 G/C cg14696996 chr19:15285081 NOTCH3 1.0 14.52 0.5 1.76e-41 Pulse pressure; BRCA cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.28 0.61 1.2e-65 Smoking behavior; BRCA cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.31 -0.35 1.95e-19 Alzheimer's disease (late onset); BRCA cis rs12474201 0.588 rs3768719 chr2:46987935 T/G cg06386533 chr2:46925753 SOCS5 0.61 12.82 0.45 1.24e-33 Height; BRCA cis rs2249625 0.816 rs2496499 chr6:72884414 T/A cg18830697 chr6:72922368 RIMS1 -0.37 -7.86 -0.3 1.63e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs4853036 0.953 rs35667002 chr2:70032867 A/G cg02498382 chr2:70120550 SNRNP27 -0.49 -8.97 -0.33 3.27e-18 Colorectal or endometrial cancer; BRCA cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.88 -0.33 6.81e-18 Bipolar disorder and schizophrenia; BRCA cis rs3733585 0.683 rs13112015 chr4:9933796 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -13.15 -0.46 4.02e-35 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4481887 0.927 rs7555310 chr1:248487638 A/G cg13385794 chr1:248469461 NA 0.27 7.92 0.3 1.09e-14 Common traits (Other); BRCA trans rs7824557 0.767 rs7003241 chr8:11169075 A/G cg06636001 chr8:8085503 FLJ10661 0.53 10.05 0.37 3.55e-22 Retinal vascular caliber; BRCA cis rs1348850 0.567 rs2222711 chr2:178534110 G/T cg22681709 chr2:178499509 PDE11A -0.38 -8.22 -0.31 1.17e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs910316 0.699 rs175039 chr14:75468950 G/C cg23033748 chr14:75592666 NEK9 -0.33 -7.9 -0.3 1.27e-14 Height; BRCA cis rs4891159 0.548 rs11150952 chr18:74128188 T/C cg24786174 chr18:74118243 ZNF516 0.84 25.36 0.71 1.06e-98 Longevity; BRCA cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg27165867 chr14:105738592 BRF1 0.36 8.79 0.33 1.42e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs4665809 1.000 rs11126340 chr2:26253255 A/G cg22920501 chr2:26401640 FAM59B -0.64 -10.82 -0.39 3.48e-25 Gut microbiome composition (summer); BRCA cis rs2116941 1.000 rs2033493 chr19:10340854 A/C cg01850179 chr19:10340795 S1PR2 -0.64 -12.54 -0.44 2.1e-32 Pulse pressure; BRCA cis rs7809950 0.678 rs13230144 chr7:106909172 T/C cg23024343 chr7:107201750 COG5 -0.44 -9.03 -0.34 1.97e-18 Coronary artery disease; BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.92 18.17 0.58 9.13e-60 Alzheimer's disease; BRCA cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4730250 0.707 rs6960148 chr7:106786142 A/G cg02696742 chr7:106810147 HBP1 0.62 9.87 0.36 1.82e-21 Osteoarthritis; BRCA cis rs507080 0.922 rs558907 chr11:118558455 A/G cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.3e-16 Serum metabolite levels; BRCA cis rs4787491 0.729 rs12446378 chr16:30043110 T/G cg06326092 chr16:30034487 C16orf92 0.38 9.93 0.37 1.07e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.04 -0.3 4.32e-15 Bipolar disorder and schizophrenia; BRCA cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg12373951 chr3:133503437 NA -0.42 -10.05 -0.37 3.63e-22 Iron status biomarkers; BRCA cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02018176 chr4:1364513 KIAA1530 0.36 7.82 0.3 2.27e-14 Longevity; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg04025307 chr7:1156635 C7orf50 0.54 13.59 0.47 3.89e-37 Longevity;Endometriosis; BRCA cis rs61931739 0.517 rs1586409 chr12:34046614 C/A cg06521331 chr12:34319734 NA -0.63 -12.21 -0.43 5.84e-31 Morning vs. evening chronotype; BRCA cis rs7085104 0.700 rs10786712 chr10:104596396 A/G cg04362960 chr10:104952993 NT5C2 -0.4 -9.7 -0.36 7.85e-21 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs5167 0.504 rs892101 chr19:45455458 G/A cg20090143 chr19:45452003 APOC2 0.27 8.07 0.3 3.42e-15 Blood protein levels; BRCA cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs66569888 0.523 rs4522599 chr2:106926004 G/C cg15412446 chr2:106886593 NA 0.45 8.93 0.33 4.61e-18 Facial morphology (factor 23); BRCA cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg13660082 chr14:53194042 PSMC6 -0.54 -8.45 -0.32 1.96e-16 Alzheimer's disease (late onset); BRCA cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.87 -0.3 1.57e-14 Aortic root size; BRCA trans rs1478897 0.575 rs12679960 chr8:11430990 C/T cg06636001 chr8:8085503 FLJ10661 0.48 9.09 0.34 1.27e-18 Systemic lupus erythematosus; BRCA trans rs911555 0.755 rs8018400 chr14:103901085 A/G cg17675199 chr6:35436792 RPL10A -0.31 -8.34 -0.31 4.62e-16 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg10556349 chr10:835070 NA 0.67 9.69 0.36 8.31e-21 Eosinophil percentage of granulocytes; BRCA cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg19077165 chr18:44547161 KATNAL2 0.37 7.9 0.3 1.19e-14 Personality dimensions; BRCA cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg13010199 chr12:38710504 ALG10B 0.42 9.07 0.34 1.45e-18 Bladder cancer; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg02353165 chr6:42928485 GNMT 0.89 23.98 0.69 3.97e-91 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs877529 0.683 rs79501 chr22:39522940 A/G cg12193277 chr22:39547181 CBX7 -0.36 -9.11 -0.34 1.01e-18 Multiple myeloma; BRCA cis rs2882667 0.788 rs11959691 chr5:138481088 C/T cg04439458 chr5:138467593 SIL1 -0.46 -11.52 -0.41 4.81e-28 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg18758796 chr5:131593413 PDLIM4 0.34 8.96 0.33 3.43e-18 Breast cancer; BRCA cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12210905 0.688 rs72845232 chr6:27428126 T/G cg08851530 chr6:28072375 NA 0.81 7.87 0.3 1.49e-14 Hip circumference adjusted for BMI; BRCA cis rs700651 0.789 rs6715070 chr2:198898265 A/G cg00792783 chr2:198669748 PLCL1 -0.39 -8.93 -0.33 4.38e-18 Intracranial aneurysm; BRCA cis rs427394 0.772 rs274689 chr5:6736215 G/C cg10857441 chr5:6722123 POLS -0.33 -11.02 -0.4 5.8e-26 Menopause (age at onset); BRCA cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.32 -10.13 -0.37 1.87e-22 Bipolar disorder; BRCA cis rs7215564 0.818 rs1531946 chr17:78630807 G/A cg06153925 chr17:78755379 RPTOR 0.48 8.35 0.31 4.08e-16 Myopia (pathological); BRCA cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg02175503 chr12:58329896 NA 0.52 10.89 0.4 1.97e-25 Intelligence (multi-trait analysis); BRCA cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.93 13.87 0.48 2.01e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9463078 0.764 rs6923519 chr6:44864152 A/G cg25276700 chr6:44698697 NA -0.35 -8.01 -0.3 5.38e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg07414643 chr4:187882934 NA 0.28 9.35 0.35 1.45e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg18305652 chr10:134549665 INPP5A 0.5 12.76 0.45 2.32e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs713587 0.520 rs487617 chr2:25309756 C/G cg01884057 chr2:25150051 NA -0.32 -8.39 -0.32 3.04e-16 Body mass index in non-asthmatics; BRCA cis rs4727027 0.865 rs62505077 chr7:148849656 T/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.91 0.4 1.61e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7772486 0.686 rs10872579 chr6:145966012 C/G cg23711669 chr6:146136114 FBXO30 0.69 15.84 0.53 6.37e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg04511125 chr2:88470314 THNSL2 0.77 12.29 0.44 2.67e-31 Plasma clusterin levels; BRCA cis rs11690935 1.000 rs1554166 chr2:172541609 G/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.84 -0.77 1.3e-128 Schizophrenia; BRCA cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg17971929 chr21:40555470 PSMG1 -0.49 -10.88 -0.4 2.13e-25 Menarche (age at onset); BRCA cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs7103648 0.695 rs12577643 chr11:47467172 A/T cg20307385 chr11:47447363 PSMC3 0.83 20.44 0.63 7.75e-72 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs11229555 0.645 rs10896778 chr11:58193925 T/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26314531 chr2:26401878 FAM59B -0.78 -12.38 -0.44 1.07e-31 Gut microbiome composition (summer); BRCA cis rs4818225 0.895 rs2837996 chr21:42626706 C/T cg21268422 chr21:42620091 BACE2 -0.43 -8.27 -0.31 7.5e-16 Educational attainment; BRCA cis rs7582180 0.629 rs13025184 chr2:100944842 A/G cg08017756 chr2:100939284 LONRF2 -0.3 -7.94 -0.3 9.14e-15 Intelligence (multi-trait analysis); BRCA cis rs1538970 0.884 rs1771551 chr1:45883643 C/G cg05343316 chr1:45956843 TESK2 0.53 10.88 0.4 2.04e-25 Platelet count; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.27 -0.44 3.3e-31 Lymphocyte counts; BRCA cis rs78456975 0.527 rs11886696 chr2:1567841 A/G cg26248373 chr2:1572462 NA -0.63 -14.28 -0.49 2.45e-40 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg00990874 chr7:1149470 C7orf50 -0.63 -13.34 -0.47 5.48e-36 Bronchopulmonary dysplasia; BRCA cis rs34779708 1.000 rs12769189 chr10:35399668 A/G cg03585969 chr10:35415529 CREM 0.56 11.45 0.41 9.48e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg00409905 chr10:38381863 ZNF37A -0.49 -10.07 -0.37 3.01e-22 Extrinsic epigenetic age acceleration; BRCA cis rs6558174 0.965 rs4872524 chr8:22489537 A/G cg03733263 chr8:22462867 KIAA1967 0.42 7.99 0.3 6.35e-15 Breast cancer; BRCA cis rs8072100 0.701 rs2013383 chr17:45791123 T/G cg08085267 chr17:45401833 C17orf57 -0.58 -11.43 -0.41 1.19e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs763121 0.853 rs138702 chr22:39132601 A/T cg21395723 chr22:39101663 GTPBP1 -0.38 -8.07 -0.3 3.45e-15 Menopause (age at onset); BRCA trans rs12517041 1.000 rs2081954 chr5:23295705 G/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.93 -0.3 1.02e-14 Calcium levels; BRCA trans rs783540 1.000 rs11637433 chr15:83321336 A/G cg18393722 chr15:85113863 UBE2QP1 0.25 7.86 0.3 1.65e-14 Schizophrenia; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg04013093 chr6:42928303 GNMT -0.28 -8.52 -0.32 1.12e-16 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs61931739 0.534 rs1490113 chr12:34132394 A/G cg06521331 chr12:34319734 NA -0.62 -11.26 -0.41 5.68e-27 Morning vs. evening chronotype; BRCA cis rs6942756 1.000 rs10954226 chr7:128953095 T/G cg02491457 chr7:128862824 NA -0.71 -14.01 -0.48 4.38e-39 White matter hyperintensity burden; BRCA cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg00631329 chr6:26305371 NA -0.42 -12.78 -0.45 1.86e-33 Educational attainment; BRCA cis rs9467711 0.591 rs60512607 chr6:26054171 T/A cg21479132 chr6:26055353 NA 0.56 7.98 0.3 6.99e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs11105298 0.891 rs4842664 chr12:89938030 G/A cg00757033 chr12:89920650 WDR51B 0.54 10.75 0.39 7.11e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs694739 0.796 rs479777 chr11:64107477 A/G cg02228329 chr11:64053129 BAD;GPR137 0.43 8.91 0.33 5.38e-18 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg08470875 chr2:26401718 FAM59B -0.51 -8.29 -0.31 6.69e-16 Gut microbiome composition (summer); BRCA cis rs4727027 0.901 rs4727019 chr7:148822266 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.34 0.41 2.89e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs61931739 0.534 rs1384860 chr12:34045388 T/C cg06521331 chr12:34319734 NA -0.63 -12.2 -0.43 6.34e-31 Morning vs. evening chronotype; BRCA cis rs6964587 0.810 rs408 chr7:91556284 A/G cg17063962 chr7:91808500 NA -0.5 -11.7 -0.42 8.41e-29 Breast cancer; BRCA cis rs4148883 0.645 rs1154404 chr4:100009004 A/T cg13256891 chr4:100009986 ADH5 0.4 8.44 0.32 2.08e-16 Alcohol dependence; BRCA trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg27661571 chr11:113659931 NA -0.46 -8.02 -0.3 5.2e-15 Hip circumference adjusted for BMI; BRCA cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs1707322 0.963 rs6429581 chr1:46319096 G/A cg06784218 chr1:46089804 CCDC17 0.49 11.74 0.42 6.06e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg18765753 chr7:1198926 ZFAND2A -0.35 -7.83 -0.3 2.06e-14 Longevity;Endometriosis; BRCA cis rs12135062 0.851 rs2651925 chr1:3101863 C/G cg25382214 chr1:3105252 PRDM16 0.33 7.9 0.3 1.26e-14 Migraine; BRCA cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg13319975 chr6:146136371 FBXO30 0.43 10.05 0.37 3.81e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs13102973 0.965 rs10434072 chr4:135867883 C/T cg14419869 chr4:135874104 NA -0.59 -12.99 -0.46 2.18e-34 Subjective well-being; BRCA trans rs11098499 0.955 rs1511019 chr4:120166007 T/G cg25214090 chr10:38739885 LOC399744 0.5 10.98 0.4 8.5e-26 Corneal astigmatism; BRCA cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg08859206 chr1:53392774 SCP2 0.42 8.31 0.31 5.61e-16 Monocyte count; BRCA cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.26e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.830 rs13148913 chr4:99009732 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.97 0.3 7.55e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3858526 0.752 rs11040173 chr11:6009378 A/G cg05234568 chr11:5960015 NA 0.45 8.8 0.33 1.28e-17 DNA methylation (variation); BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg00166722 chr3:10149974 C3orf24 0.64 11.05 0.4 4.19e-26 Alzheimer's disease; BRCA cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg12591125 chr7:1885375 MAD1L1 -0.49 -8.54 -0.32 9.83e-17 Bipolar disorder; BRCA trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg15704280 chr7:45808275 SEPT13 -0.46 -8.91 -0.33 5.36e-18 HDL cholesterol; BRCA cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg24558204 chr6:135376177 HBS1L 0.59 15.94 0.53 2.1e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9287719 0.967 rs715247 chr2:10736291 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg27661571 chr11:113659931 NA -0.75 -11.56 -0.42 3.28e-28 Hip circumference adjusted for BMI; BRCA cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.51 10.13 0.37 1.81e-22 Tonsillectomy; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg10729496 chr3:10149963 C3orf24 0.42 8.08 0.3 3.25e-15 Alzheimer's disease; BRCA cis rs11051970 0.545 rs2651374 chr12:32582858 G/A cg24626660 chr12:32551988 NA 0.28 8.16 0.31 1.78e-15 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs11098499 0.954 rs7654587 chr4:120388406 C/T cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs10848704 0.637 rs11062351 chr12:2881763 C/T cg19995117 chr12:2880862 NA 0.38 9.76 0.36 4.57e-21 Quantitative traits; BRCA trans rs11098499 0.954 rs12507964 chr4:120413061 T/A cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.76e-30 Corneal astigmatism; BRCA cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg16482183 chr6:26056742 HIST1H1C 0.52 11.29 0.41 4.38e-27 Iron status biomarkers; BRCA cis rs9399135 0.967 rs4637662 chr6:135298158 T/C cg24558204 chr6:135376177 HBS1L 0.46 12.54 0.44 2.12e-32 Red blood cell count; BRCA cis rs798554 0.549 rs1623138 chr7:2899410 A/G cg13628971 chr7:2884303 GNA12 0.45 10.16 0.37 1.38e-22 Height; BRCA cis rs1949733 0.666 rs3103070 chr4:8508825 A/G cg11789530 chr4:8429930 ACOX3 -0.63 -15.96 -0.53 1.62e-48 Response to antineoplastic agents; BRCA trans rs1493916 1.000 rs11081827 chr18:31390228 C/A cg27147174 chr7:100797783 AP1S1 -0.52 -10.06 -0.37 3.29e-22 Life satisfaction; BRCA cis rs72781680 0.611 rs72797824 chr2:24356456 T/G cg20701182 chr2:24300061 SF3B14 0.7 13.19 0.46 2.67e-35 Lymphocyte counts; BRCA cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg04267008 chr7:1944627 MAD1L1 -0.39 -8.47 -0.32 1.66e-16 Schizophrenia; BRCA cis rs9560113 0.959 rs4773385 chr13:112178452 C/T cg10483660 chr13:112241077 NA 0.32 7.86 0.3 1.65e-14 Menarche (age at onset); BRCA cis rs911555 0.755 rs10148970 chr14:103892000 G/A cg24130564 chr14:104152367 KLC1 -0.39 -9.01 -0.34 2.39e-18 Intelligence (multi-trait analysis); BRCA cis rs637571 0.522 rs1151512 chr11:65757533 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.61 13.78 0.48 5.11e-38 Eosinophil percentage of white cells; BRCA cis rs514406 0.505 rs374662 chr1:53164549 C/A cg16325326 chr1:53192061 ZYG11B 0.86 25.26 0.71 3.77e-98 Monocyte count; BRCA cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg06060754 chr5:176797920 RGS14 0.57 10.99 0.4 7.71e-26 Hemoglobin concentration;Hematocrit; BRCA cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg25554036 chr4:6271136 WFS1 0.37 9.09 0.34 1.26e-18 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7666738 0.962 rs13147921 chr4:99069296 C/G cg17366294 chr4:99064904 C4orf37 0.49 10.85 0.39 2.84e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs45509595 0.556 rs34409918 chr6:27685348 A/G cg01620082 chr3:125678407 NA -0.92 -10.33 -0.38 3.07e-23 Breast cancer; BRCA cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.29 0.31 6.45e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg04166393 chr7:2884313 GNA12 0.42 9.09 0.34 1.21e-18 Height; BRCA trans rs2018683 0.739 rs10233884 chr7:28972307 A/G cg19402173 chr7:128379420 CALU -0.43 -10.15 -0.37 1.58e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6964587 0.900 rs6465352 chr7:91775117 A/G cg17063962 chr7:91808500 NA 0.6 14.47 0.5 2.89e-41 Breast cancer; BRCA cis rs7264396 0.563 rs2425132 chr20:34338390 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -11.12 -0.4 2.24e-26 Total cholesterol levels; BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg03709012 chr19:19516395 GATAD2A 0.8 18.73 0.6 1.02e-62 Tonsillectomy; BRCA cis rs11105298 0.786 rs3803128 chr12:89860319 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.94 -0.37 9.36e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9291683 0.527 rs3822241 chr4:10094931 G/A cg00071950 chr4:10020882 SLC2A9 -0.54 -12.63 -0.45 8.29e-33 Bone mineral density; BRCA cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.56 11.43 0.41 1.2e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs9837602 1.000 rs1688766 chr3:99647850 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.43 0.41 1.19e-27 Breast cancer; BRCA cis rs589448 0.902 rs315134 chr12:69762713 G/A cg20891283 chr12:69753455 YEATS4 0.84 28.23 0.74 2.01e-114 Cerebrospinal fluid biomarker levels; BRCA cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg18351406 chr4:77819688 ANKRD56 0.57 12.82 0.45 1.27e-33 Emphysema distribution in smoking; BRCA cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg24060327 chr5:131705240 SLC22A5 -0.63 -11.79 -0.42 3.77e-29 Breast cancer; BRCA cis rs16958440 1.000 rs16958440 chr18:44632884 C/G cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs2839186 0.596 rs4819217 chr21:47644092 G/T cg12379764 chr21:47803548 PCNT -0.38 -7.87 -0.3 1.49e-14 Testicular germ cell tumor; BRCA cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg00071950 chr4:10020882 SLC2A9 -0.51 -11.44 -0.41 1.03e-27 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9420 0.528 rs7102271 chr11:57396825 G/T cg19752551 chr11:57585705 CTNND1 -0.38 -9.47 -0.35 5.28e-20 Schizophrenia; BRCA cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg12193833 chr17:30244370 NA -0.58 -8.78 -0.33 1.54e-17 Hip circumference adjusted for BMI; BRCA cis rs17253792 0.545 rs12893676 chr14:56016159 G/A cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg13010199 chr12:38710504 ALG10B -0.38 -8.7 -0.33 2.89e-17 Morning vs. evening chronotype; BRCA cis rs250677 0.687 rs250678 chr5:148434830 C/T cg18129178 chr5:148520854 ABLIM3 -0.6 -12.44 -0.44 5.54e-32 Breast cancer; BRCA cis rs2276314 0.857 rs59649576 chr18:33616075 G/T cg19628046 chr18:33552617 C18orf21 0.55 11.22 0.41 8.23e-27 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs372883 0.613 rs1153274 chr21:30660026 T/C cg08807101 chr21:30365312 RNF160 -0.42 -8.82 -0.33 1.11e-17 Pancreatic cancer; BRCA cis rs9430161 0.579 rs9659356 chr1:11034817 A/G cg02454025 chr1:11042201 C1orf127 1.0 23.33 0.68 1.46e-87 Ewing sarcoma; BRCA cis rs7927771 0.832 rs1317164 chr11:47419757 G/T cg20307385 chr11:47447363 PSMC3 -0.43 -8.83 -0.33 1.04e-17 Subjective well-being; BRCA cis rs6831352 0.918 rs13107558 chr4:100050200 C/A cg12011299 chr4:100065546 ADH4 -0.43 -9.83 -0.36 2.56e-21 Alcohol dependence; BRCA cis rs8062405 0.755 rs62034358 chr16:28587597 G/T cg16576597 chr16:28551801 NUPR1 0.35 9.46 0.35 5.9e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.78 -11.48 -0.41 7.14e-28 Platelet count; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.38e-19 Menopause (age at onset); BRCA cis rs2425143 0.908 rs12480111 chr20:34423186 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.18 -0.31 1.59e-15 Blood protein levels; BRCA cis rs870825 0.929 rs72689262 chr4:185590950 C/G cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA trans rs1997103 0.954 rs10246216 chr7:55390479 C/T cg20935933 chr6:143382018 AIG1 0.61 11.61 0.42 2.03e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg00012203 chr2:219082015 ARPC2 0.46 9.17 0.34 6.48e-19 Ulcerative colitis; BRCA cis rs6062302 0.522 rs2282157 chr20:62227180 C/G cg16989086 chr20:62203971 PRIC285 0.53 8.94 0.33 4.21e-18 Glioblastoma; BRCA cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg05985134 chr18:33552581 C18orf21 0.65 11.93 0.43 8.81e-30 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg09184832 chr6:79620586 NA -0.42 -8.45 -0.32 1.93e-16 Intelligence (multi-trait analysis); BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.37 -8.8 -0.33 1.22e-17 Tonsillectomy; BRCA cis rs1050631 0.564 rs1785904 chr18:33713132 T/C cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.99 -0.3 6.25e-15 Esophageal squamous cell cancer (length of survival); BRCA cis rs6433895 0.710 rs34467063 chr2:182013979 G/A cg00481216 chr2:181971175 NA 0.45 8.29 0.31 6.5e-16 Lymphocyte counts; BRCA cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg24399712 chr22:39784796 NA -0.58 -13.53 -0.47 7.42e-37 Intelligence (multi-trait analysis); BRCA cis rs3749237 0.964 rs2234385 chr3:49846041 G/A cg07636037 chr3:49044803 WDR6 0.4 8.15 0.31 1.98e-15 Resting heart rate; BRCA cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.52 0.57 2.09e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg04025307 chr7:1156635 C7orf50 0.54 10.56 0.39 3.81e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.86 -0.3 1.65e-14 Corneal astigmatism; BRCA trans rs11722228 0.521 rs12501336 chr4:10137351 G/A cg26043149 chr18:55253948 FECH 1.2 28.3 0.75 7.58e-115 Gout;Urate levels;Serum uric acid levels; BRCA cis rs796364 0.760 rs74993507 chr2:201068684 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -9.7 -0.36 7.47e-21 Schizophrenia; BRCA cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg07636037 chr3:49044803 WDR6 0.99 29.87 0.76 2.34e-123 Parkinson's disease; BRCA cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.65 16.37 0.54 1.54e-50 Colorectal cancer; BRCA cis rs2070488 1.000 rs762317 chr3:38497659 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.57 0.63 1.58e-72 Electrocardiographic conduction measures; BRCA cis rs3845702 0.736 rs72960701 chr2:180851202 A/T cg01881094 chr2:180872142 CWC22 1.0 17.29 0.56 3.18e-55 Schizophrenia; BRCA cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg08085267 chr17:45401833 C17orf57 -0.59 -11.98 -0.43 5.69e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6060717 0.536 rs8125393 chr20:34496162 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.18 -0.31 1.55e-15 Hip circumference adjusted for BMI; BRCA cis rs8177253 0.696 rs4459901 chr3:133465699 T/C cg01448562 chr3:133502909 NA -0.39 -8.77 -0.33 1.55e-17 Iron status biomarkers; BRCA cis rs7020830 0.898 rs7857936 chr9:37078491 T/C cg14294708 chr9:37120828 ZCCHC7 1.09 33.73 0.8 4.76e-144 Schizophrenia; BRCA cis rs61931739 0.500 rs12146843 chr12:34451738 T/G cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.8e-23 Morning vs. evening chronotype; BRCA cis rs9297145 0.678 rs62473048 chr7:98775511 T/C cg05967295 chr7:98741636 SMURF1 0.98 18.7 0.59 1.37e-62 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs9914988 0.778 rs4794837 chr17:27110024 T/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg18196295 chr10:418757 DIP2C 0.49 11.7 0.42 9.11e-29 Psychosis in Alzheimer's disease; BRCA cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.75 -0.5 1.4e-42 Chronic sinus infection; BRCA cis rs9880211 0.821 rs9832813 chr3:136065565 A/G cg21827317 chr3:136751795 NA -0.41 -8.3 -0.31 6.07e-16 Body mass index;Height; BRCA cis rs3784262 0.692 rs4646590 chr15:58303137 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.23 -0.38 7.19e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs57221529 0.766 rs56350081 chr5:583198 G/A cg20362242 chr5:692897 TPPP 0.55 8.25 0.31 9.14e-16 Lung disease severity in cystic fibrosis; BRCA cis rs8017423 0.791 rs7146250 chr14:90711703 A/G cg14092571 chr14:90743983 NA -0.33 -8.02 -0.3 5.11e-15 Mortality in heart failure; BRCA cis rs9300255 0.602 rs1106240 chr12:123626982 C/T cg00376283 chr12:123451042 ABCB9 0.53 10.79 0.39 4.69e-25 Neutrophil percentage of white cells; BRCA cis rs2153535 0.563 rs1796687 chr6:8536118 C/G cg21535247 chr6:8435926 SLC35B3 0.4 9.07 0.34 1.51e-18 Motion sickness; BRCA cis rs10754283 0.967 rs2185195 chr1:90106697 T/C cg21401794 chr1:90099060 LRRC8C 0.46 11.13 0.4 2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7666738 0.830 rs28587201 chr4:98991733 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.32e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7631605 0.846 rs11926768 chr3:36968347 C/T cg15934958 chr3:37212084 LRRFIP2 -0.46 -10.41 -0.38 1.53e-23 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.830 rs6843777 chr4:98866635 T/A cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.83e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7191439 0.674 rs4782430 chr16:88792047 A/G cg27087555 chr16:88793112 FAM38A -1.3 -20.17 -0.62 2.3e-70 Plateletcrit; BRCA cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg16850897 chr7:100343110 ZAN -0.57 -10.93 -0.4 1.36e-25 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs11098499 0.675 rs11098534 chr4:120556772 T/G cg25214090 chr10:38739885 LOC399744 0.44 9.86 0.36 1.84e-21 Corneal astigmatism; BRCA trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.93 0.3 1.01e-14 Corneal astigmatism; BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.64 0.39 1.95e-24 Tonsillectomy; BRCA cis rs16854884 0.770 rs1530477 chr3:143819506 A/G cg06585982 chr3:143692056 C3orf58 -0.42 -8.22 -0.31 1.14e-15 Economic and political preferences (feminism/equality); BRCA cis rs7412746 0.611 rs11204726 chr1:150743492 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.98 0.3 6.98e-15 Melanoma; BRCA cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg03517284 chr6:25882590 NA -0.47 -10.66 -0.39 1.57e-24 Blood metabolite levels; BRCA cis rs3768617 0.510 rs4651142 chr1:183097386 A/T ch.1.3577855R chr1:183094577 LAMC1 0.66 17.13 0.56 2.16e-54 Fuchs's corneal dystrophy; BRCA trans rs11250097 0.549 rs11778177 chr8:11310362 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -10.1 -0.37 2.37e-22 Neuroticism; BRCA cis rs6088813 1.000 rs6142376 chr20:33992761 T/A cg14752227 chr20:34000481 UQCC -0.42 -8.92 -0.33 4.84e-18 Height; BRCA cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg10546459 chr2:36825355 FEZ2 -0.4 -7.89 -0.3 1.3e-14 Height; BRCA cis rs477692 1.000 rs530466 chr10:131427717 A/G cg05714579 chr10:131428358 MGMT 0.58 14.27 0.49 2.62e-40 Response to temozolomide; BRCA cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg21132104 chr15:45694354 SPATA5L1 0.75 17.12 0.56 2.4e-54 Homoarginine levels; BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.14 0.34 8.5e-19 Tonsillectomy; BRCA cis rs75804782 0.641 rs2340870 chr2:239356026 C/T cg18131467 chr2:239335373 ASB1 -0.61 -7.98 -0.3 6.63e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs6121246 0.865 rs6058421 chr20:30295013 G/C cg13852791 chr20:30311386 BCL2L1 0.86 16.75 0.55 1.82e-52 Mean corpuscular hemoglobin; BRCA cis rs9420 0.528 rs10896632 chr11:57390302 G/A cg19752551 chr11:57585705 CTNND1 -0.38 -9.32 -0.35 1.87e-19 Schizophrenia; BRCA cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg00745463 chr17:30367425 LRRC37B -0.53 -8.91 -0.33 5.36e-18 Hip circumference adjusted for BMI; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg04025307 chr7:1156635 C7orf50 0.45 9.09 0.34 1.28e-18 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg17366294 chr4:99064904 C4orf37 0.55 11.77 0.42 4.52e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs4787491 0.729 rs8043883 chr16:30044581 G/A cg06326092 chr16:30034487 C16orf92 0.38 9.9 0.36 1.36e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg03676636 chr4:99064102 C4orf37 0.23 8.26 0.31 8.09e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg05283184 chr6:79620031 NA -0.43 -10.98 -0.4 8.34e-26 Intelligence (multi-trait analysis); BRCA cis rs616402 0.527 rs10779737 chr1:10580275 C/G cg17425144 chr1:10567563 PEX14 0.58 15.64 0.53 6.23e-47 Breast size; BRCA cis rs9581857 0.685 rs9319371 chr13:28042564 A/G cg22138327 chr13:27999177 GTF3A 0.63 9.63 0.36 1.33e-20 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); BRCA cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg01191920 chr7:158217561 PTPRN2 -0.42 -9.98 -0.37 6.5e-22 Obesity-related traits; BRCA cis rs6142102 0.602 rs4911380 chr20:32546224 C/T cg24642439 chr20:33292090 TP53INP2 0.39 7.81 0.3 2.37e-14 Skin pigmentation; BRCA cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -12.62 -0.45 9.4e-33 Body mass index; BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg11814155 chr7:99998594 ZCWPW1 0.51 9.0 0.34 2.51e-18 Platelet count; BRCA trans rs11098499 0.863 rs11947234 chr4:120474859 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs61931739 0.500 rs1601628 chr12:34047375 A/C cg06521331 chr12:34319734 NA -0.63 -12.21 -0.43 5.84e-31 Morning vs. evening chronotype; BRCA cis rs1707322 0.752 rs7541962 chr1:46235117 G/A cg06784218 chr1:46089804 CCDC17 0.5 11.97 0.43 6.26e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3768617 0.610 rs10911228 chr1:183049792 T/C ch.1.3577855R chr1:183094577 LAMC1 0.44 9.47 0.35 5.23e-20 Fuchs's corneal dystrophy; BRCA cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg26408565 chr15:76604113 ETFA -0.49 -10.41 -0.38 1.45e-23 Blood metabolite levels; BRCA cis rs9325144 0.624 rs10783329 chr12:39113951 C/T cg26384229 chr12:38710491 ALG10B -0.47 -10.72 -0.39 9.19e-25 Morning vs. evening chronotype; BRCA cis rs7737355 0.947 rs10041744 chr5:130860852 C/T cg06307176 chr5:131281290 NA 0.52 10.39 0.38 1.87e-23 Life satisfaction; BRCA cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.54 8.42 0.32 2.49e-16 Lung function (FEV1/FVC); BRCA cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg17892150 chr10:133769511 PPP2R2D -0.72 -15.25 -0.52 5.14e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2576037 0.583 rs646128 chr18:44397691 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -10.21 -0.37 8.99e-23 Personality dimensions; BRCA cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg24531977 chr5:56204891 C5orf35 1.01 20.25 0.63 7.72e-71 Initial pursuit acceleration; BRCA cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -9.28 -0.34 2.56e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6570726 0.791 rs6915094 chr6:145883540 C/G cg05347473 chr6:146136440 FBXO30 0.43 8.56 0.32 8.72e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg03433033 chr1:76189801 ACADM 0.69 13.03 0.46 1.35e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs8017423 0.536 rs11625794 chr14:90811229 C/T cg04374321 chr14:90722782 PSMC1 0.4 8.84 0.33 8.9e-18 Mortality in heart failure; BRCA cis rs332507 0.830 rs2289428 chr3:124412524 T/G cg05980111 chr3:124395277 KALRN 0.34 8.13 0.31 2.28e-15 Plateletcrit; BRCA cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg10556349 chr10:835070 NA 0.6 8.31 0.31 5.55e-16 Eosinophil percentage of granulocytes; BRCA cis rs2404602 1.000 rs2896954 chr15:76851692 C/A cg23625390 chr15:77176239 SCAPER 0.43 10.5 0.38 6.47e-24 Blood metabolite levels; BRCA cis rs4409675 0.576 rs7356 chr1:28218100 T/C cg23691781 chr1:28212827 C1orf38 0.33 11.21 0.41 9.92e-27 Corneal astigmatism; BRCA cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.22 0.31 1.17e-15 Mean platelet volume; BRCA trans rs61931739 0.534 rs7302688 chr12:34235064 A/G cg26384229 chr12:38710491 ALG10B 0.68 14.35 0.49 1.06e-40 Morning vs. evening chronotype; BRCA cis rs3849570 1.000 rs9842330 chr3:81814688 G/A cg07356753 chr3:81810745 GBE1 -0.47 -11.34 -0.41 2.71e-27 Waist circumference;Body mass index; BRCA cis rs9549328 0.765 rs1317506 chr13:113631143 C/T cg01248385 chr13:113636953 MCF2L -0.41 -8.78 -0.33 1.54e-17 Systolic blood pressure; BRCA cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg06784218 chr1:46089804 CCDC17 0.47 11.27 0.41 5.28e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg00852783 chr1:26633632 UBXN11 0.5 10.72 0.39 8.96e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs2953174 0.786 rs8662 chr2:241517770 G/A cg07929629 chr2:241523174 NA 0.49 8.58 0.32 6.97e-17 Bipolar disorder; BRCA cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs11155671 0.530 rs7763849 chr6:150206380 C/T cg13206674 chr6:150067644 NUP43 0.28 8.42 0.32 2.56e-16 Testicular germ cell tumor; BRCA cis rs3771570 0.901 rs62190407 chr2:242405772 G/A cg21155796 chr2:242212141 HDLBP 0.51 8.8 0.33 1.23e-17 Prostate cancer; BRCA cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg15556689 chr8:8085844 FLJ10661 0.43 12.27 0.44 3.29e-31 Neuroticism; BRCA cis rs6088813 1.000 rs4911496 chr20:33972053 A/G cg14752227 chr20:34000481 UQCC 0.43 9.23 0.34 3.76e-19 Height; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg09177884 chr7:1199841 ZFAND2A -0.43 -9.62 -0.36 1.52e-20 Longevity;Endometriosis; BRCA cis rs1538970 0.962 rs9429160 chr1:45827968 G/T cg05343316 chr1:45956843 TESK2 0.56 11.32 0.41 3.38e-27 Platelet count; BRCA cis rs2832077 0.689 rs2832052 chr21:30130073 G/C cg24692254 chr21:30365293 RNF160 -0.41 -8.52 -0.32 1.15e-16 Cognitive test performance; BRCA cis rs10484885 0.878 rs17763820 chr6:90569634 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.77 -0.36 4.16e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg13660082 chr14:53194042 PSMC6 -0.56 -8.05 -0.3 4.16e-15 Alzheimer's disease (late onset); BRCA cis rs7246657 0.941 rs7259618 chr19:37750719 G/A cg18154014 chr19:37997991 ZNF793 0.55 10.12 0.37 1.92e-22 Coronary artery calcification; BRCA cis rs9815354 0.761 rs73079307 chr3:41862273 A/C cg03022575 chr3:42003672 ULK4 0.69 9.47 0.35 5.31e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg21918786 chr6:109611834 NA -0.47 -13.43 -0.47 2.09e-36 Reticulocyte fraction of red cells; BRCA cis rs61931739 0.500 rs10844864 chr12:34532468 A/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.26e-22 Morning vs. evening chronotype; BRCA cis rs10716631 1 rs10716631 chr2:219138170 T/G cg00012203 chr2:219082015 ARPC2 0.64 13.16 0.46 3.48e-35 High light scatter reticulocyte percentage of red cells;Plateletcrit; BRCA cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg24110177 chr3:50126178 RBM5 0.4 11.1 0.4 2.56e-26 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.834 rs6919423 chr6:109558471 C/T cg01475377 chr6:109611718 NA -0.4 -9.92 -0.37 1.13e-21 Reticulocyte fraction of red cells; BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg24531977 chr5:56204891 C5orf35 -0.74 -14.83 -0.51 5.4e-43 Initial pursuit acceleration; BRCA cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg05340658 chr4:99064831 C4orf37 0.57 11.39 0.41 1.67e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg02880119 chr16:3481970 NA 0.44 8.16 0.31 1.76e-15 Body mass index (adult); BRCA cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg02079420 chr8:82753780 SNX16 -0.31 -8.53 -0.32 1.04e-16 Diastolic blood pressure; BRCA cis rs12367572 0.641 rs4285943 chr12:45404768 A/C cg04608330 chr12:45269318 NELL2 0.45 9.88 0.36 1.59e-21 Gut microbiome composition (summer); BRCA cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg02574844 chr11:5959923 NA -0.39 -8.1 -0.31 2.85e-15 DNA methylation (variation); BRCA cis rs911119 1.000 rs6036476 chr20:23610308 C/G cg16589663 chr20:23618590 CST3 0.45 8.48 0.32 1.51e-16 Chronic kidney disease; BRCA cis rs7592578 0.771 rs12053190 chr2:191383348 A/G cg10560079 chr2:191398806 TMEM194B -0.73 -13.44 -0.47 1.84e-36 Diastolic blood pressure; BRCA cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.21 0.34 4.81e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7587476 1.000 rs3768707 chr2:215645135 C/T cg04004882 chr2:215674386 BARD1 0.57 10.92 0.4 1.37e-25 Neuroblastoma; BRCA cis rs351855 0.642 rs2546095 chr5:176509584 G/T cg19956155 chr5:176511416 NA 0.35 7.89 0.3 1.3e-14 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -9.4 -0.35 9.91e-20 Developmental language disorder (linguistic errors); BRCA cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.52 8.98 0.33 2.94e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2270927 0.510 rs13188781 chr5:75580409 C/A cg13563193 chr19:33072644 PDCD5 0.9 10.35 0.38 2.48e-23 Mean corpuscular volume; BRCA cis rs9467773 0.596 rs2451750 chr6:26646579 A/T cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.29e-42 Intelligence (multi-trait analysis); BRCA trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -8.97 -0.33 3.17e-18 Axial length; BRCA cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg13770153 chr20:60521292 NA -0.38 -9.01 -0.34 2.35e-18 Body mass index; BRCA cis rs2288073 0.965 rs13395596 chr2:24410738 T/C cg06627628 chr2:24431161 ITSN2 -0.63 -12.02 -0.43 3.88e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7917772 0.505 rs61869211 chr10:104449836 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.49 11.88 0.43 1.54e-29 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7246657 0.722 rs6508736 chr19:38061757 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.13 0.34 8.69e-19 Coronary artery calcification; BRCA cis rs2797160 1.000 rs6934435 chr6:126017481 T/G cg05901451 chr6:126070800 HEY2 0.4 9.75 0.36 4.92e-21 Endometrial cancer; BRCA cis rs9291683 0.530 rs6449196 chr4:9973660 C/T cg00071950 chr4:10020882 SLC2A9 -0.53 -13.22 -0.46 1.9e-35 Bone mineral density; BRCA cis rs2882667 0.654 rs10044432 chr5:138274896 C/T cg04439458 chr5:138467593 SIL1 -0.35 -8.5 -0.32 1.33e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg21918786 chr6:109611834 NA -0.46 -12.86 -0.45 7.78e-34 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg17366294 chr4:99064904 C4orf37 0.41 9.74 0.36 5.42e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.77e-26 Extrinsic epigenetic age acceleration; BRCA cis rs1949733 1.000 rs3103067 chr4:8511223 A/G cg13073564 chr4:8508604 NA -0.41 -11.36 -0.41 2.23e-27 Response to antineoplastic agents; BRCA trans rs1005277 0.505 rs200935 chr10:38132810 T/A cg17830980 chr10:43048298 ZNF37B -0.41 -9.68 -0.36 9.39e-21 Extrinsic epigenetic age acceleration; BRCA cis rs798766 1.000 rs798767 chr4:1734281 A/G cg05874882 chr4:1763078 NA -0.45 -8.14 -0.31 2.08e-15 Bladder cancer;Urinary bladder cancer; BRCA cis rs6840360 0.571 rs2407069 chr4:152533201 G/A cg22705602 chr4:152727874 NA -0.32 -8.3 -0.31 6.17e-16 Intelligence (multi-trait analysis); BRCA cis rs666930 0.519 rs477992 chr1:120257576 A/G cg19096424 chr1:120255104 PHGDH 0.54 12.29 0.44 2.71e-31 Breast cancer; BRCA cis rs11719291 0.504 rs34571182 chr3:49209057 T/A cg00383909 chr3:49044727 WDR6 0.77 13.06 0.46 9.67e-35 Cognitive function; BRCA trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.14 0.31 2.04e-15 Corneal astigmatism; BRCA cis rs9549260 1.000 rs9549260 chr13:41254104 G/T cg21288729 chr13:41239152 FOXO1 0.5 9.59 0.35 1.97e-20 Red blood cell count; BRCA cis rs1707322 1.000 rs11211235 chr1:46440375 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg05340658 chr4:99064831 C4orf37 0.6 12.93 0.46 3.99e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs977987 0.806 rs4887824 chr16:75441613 T/C cg03315344 chr16:75512273 CHST6 0.53 12.42 0.44 7.12e-32 Dupuytren's disease; BRCA cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg12927641 chr6:109611667 NA -0.42 -10.85 -0.39 2.82e-25 Reticulocyte fraction of red cells; BRCA cis rs6882716 0.636 rs1470023 chr5:10800150 A/G cg14521931 chr5:10832172 NA -0.68 -12.03 -0.43 3.33e-30 Alcohol consumption (maxi-drinks); BRCA cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg06671706 chr8:8559999 CLDN23 0.44 8.63 0.32 4.94e-17 Obesity-related traits; BRCA cis rs11229555 0.645 rs72917641 chr11:58227320 A/C cg15696309 chr11:58395628 NA -0.52 -10.85 -0.39 2.81e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2153535 0.580 rs1414346 chr6:8471574 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs11718455 0.920 rs13084408 chr3:44008967 G/A cg08738300 chr3:44038990 NA 0.46 9.01 0.34 2.44e-18 Coronary artery disease; BRCA cis rs3768617 0.510 rs2296292 chr1:183086757 A/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA cis rs10046574 0.519 rs7799873 chr7:135214030 C/T cg27474649 chr7:135195673 CNOT4 0.63 10.71 0.39 9.6e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06022373 chr22:39101656 GTPBP1 -0.72 -17.34 -0.57 1.65e-55 Menopause (age at onset); BRCA cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.55 14.2 0.49 5.5e-40 Colorectal cancer; BRCA cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg08999081 chr20:33150536 PIGU 0.46 12.96 0.46 2.82e-34 Glomerular filtration rate (creatinine); BRCA cis rs7552404 1.000 rs7518038 chr1:76154430 G/A cg22875332 chr1:76189707 ACADM 0.69 14.94 0.51 1.62e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10751667 0.666 rs10902249 chr11:958566 C/T ch.11.42038R chr11:967971 AP2A2 -0.51 -16.37 -0.54 1.44e-50 Alzheimer's disease (late onset); BRCA cis rs8180040 0.654 rs6766230 chr3:47196209 C/A cg27129171 chr3:47204927 SETD2 0.72 17.52 0.57 2.13e-56 Colorectal cancer; BRCA cis rs6484504 0.576 rs16922084 chr11:31371109 C/T cg26647111 chr11:31128758 NA 0.45 9.59 0.35 1.97e-20 Red blood cell count; BRCA cis rs2032447 0.670 rs198850 chr6:26104670 A/C cg03264133 chr6:25882463 NA 0.41 8.8 0.33 1.26e-17 Intelligence (multi-trait analysis); BRCA cis rs796364 0.806 rs78037592 chr2:201105734 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.61 -8.52 -0.32 1.16e-16 Schizophrenia; BRCA trans rs617791 0.530 rs10896073 chr11:65762814 T/C cg17712092 chr4:129076599 LARP1B -0.49 -10.64 -0.39 1.82e-24 Breast cancer; BRCA cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg04450456 chr4:17643702 FAM184B 0.38 11.15 0.4 1.66e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs208520 0.690 rs2797693 chr6:66868985 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -20.44 -0.63 7.57e-72 Exhaled nitric oxide output; BRCA cis rs3845702 0.736 rs16867131 chr2:180848651 A/G cg01881094 chr2:180872142 CWC22 -1.02 -17.25 -0.56 4.87e-55 Schizophrenia; BRCA cis rs11190604 0.767 rs7078070 chr10:102166415 A/C cg07080220 chr10:102295463 HIF1AN 0.49 10.13 0.37 1.82e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.24 -0.31 1e-15 Gut microbiome composition (summer); BRCA cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.09 0.43 1.87e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg01579765 chr21:45077557 HSF2BP -0.42 -10.08 -0.37 2.79e-22 Mean corpuscular volume; BRCA cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 11.88 0.43 1.49e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs34193460 chr7:65393110 A/G cg18252515 chr7:66147081 NA -0.91 -12.95 -0.46 3.15e-34 Diabetic kidney disease; BRCA cis rs9467773 0.620 rs2504565 chr6:26656890 G/A cg09904177 chr6:26538194 HMGN4 0.47 14.67 0.5 3.4e-42 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs12048412 chr1:152977092 A/T cg21543102 chr1:152974771 SPRR3 -0.28 -8.12 -0.31 2.44e-15 Inflammatory skin disease; BRCA cis rs2066819 1.000 rs75265219 chr12:56640341 G/A cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs7267979 0.932 rs449703 chr20:25458559 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.85 0.33 8.73e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7615952 0.515 rs4267608 chr3:125680500 C/T cg05084668 chr3:125655381 ALG1L -0.65 -12.45 -0.44 5.16e-32 Blood pressure (smoking interaction); BRCA cis rs13217239 0.621 rs12527231 chr6:27001288 G/A cg12292205 chr6:26970375 C6orf41 0.58 13.03 0.46 1.32e-34 Schizophrenia; BRCA cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.96 -0.3 7.86e-15 Aortic root size; BRCA trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg06636001 chr8:8085503 FLJ10661 0.59 12.1 0.43 1.76e-30 Mood instability; BRCA cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg18404041 chr3:52824283 ITIH1 0.46 13.33 0.47 5.9e-36 Bipolar disorder; BRCA cis rs992157 0.560 rs4674275 chr2:219097738 G/A cg00012203 chr2:219082015 ARPC2 -0.57 -12.06 -0.43 2.51e-30 Colorectal cancer; BRCA cis rs7617773 0.817 rs11709691 chr3:48303669 A/G cg11946769 chr3:48343235 NME6 0.67 13.86 0.48 2.14e-38 Coronary artery disease; BRCA cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg18404041 chr3:52824283 ITIH1 -0.28 -8.55 -0.32 8.75e-17 Electroencephalogram traits; BRCA cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs9435341 0.929 rs1730865 chr1:107605611 A/C cg09367891 chr1:107599246 PRMT6 0.55 10.12 0.37 2.02e-22 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.52 0.35 3.42e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6598955 0.543 rs881578 chr1:26536141 G/A cg04990556 chr1:26633338 UBXN11 0.71 12.02 0.43 3.79e-30 Obesity-related traits; BRCA trans rs3960554 0.808 rs111714534 chr7:75748896 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 11.77 0.42 4.43e-29 Eotaxin levels; BRCA cis rs8008758 0.517 rs1772024 chr14:101695220 A/C cg26224664 chr14:101693935 NA 0.41 11.25 0.41 6.46e-27 Body mass index (alcohol intake interaction); BRCA cis rs8114671 0.662 rs6088664 chr20:33551100 G/A cg07148914 chr20:33460835 GGT7 0.44 9.62 0.36 1.52e-20 Height; BRCA cis rs600806 0.850 rs3931560 chr1:109966718 A/C cg20591472 chr1:110008990 SYPL2 0.33 8.38 0.31 3.42e-16 Intelligence (multi-trait analysis); BRCA cis rs1050631 0.564 rs589213 chr18:33743610 G/A cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.86 -0.3 1.6e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg11814155 chr7:99998594 ZCWPW1 0.48 8.78 0.33 1.48e-17 Platelet count; BRCA cis rs10484885 0.775 rs55926724 chr6:90417450 A/C cg13799429 chr6:90582589 CASP8AP2 -0.7 -10.65 -0.39 1.79e-24 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 1.97e-48 Bladder cancer; BRCA cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg00684032 chr4:1343700 KIAA1530 0.32 7.96 0.3 7.86e-15 Obesity-related traits; BRCA cis rs6815814 0.861 rs7658651 chr4:38786002 A/C cg06935464 chr4:38784597 TLR10 0.49 9.87 0.36 1.76e-21 Breast cancer; BRCA cis rs9814567 1.000 rs6790466 chr3:134197740 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.56 -0.32 8.35e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7524258 0.868 rs10779678 chr1:7300573 A/G cg07173049 chr1:7289937 CAMTA1 0.53 12.7 0.45 4.06e-33 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg04025307 chr7:1156635 C7orf50 0.59 15.15 0.51 1.55e-44 Longevity;Endometriosis; BRCA cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.45 -0.35 6.43e-20 Menopause (age at onset); BRCA cis rs11229555 0.645 rs12805062 chr11:58214584 A/G cg15696309 chr11:58395628 NA -0.45 -9.64 -0.36 1.27e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg24549020 chr5:56110836 MAP3K1 -0.58 -10.61 -0.39 2.48e-24 Initial pursuit acceleration; BRCA cis rs12142240 0.698 rs56284503 chr1:46847127 C/G cg10495392 chr1:46806563 NSUN4 0.45 8.49 0.32 1.42e-16 Menopause (age at onset); BRCA cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg08754478 chr10:133766260 PPP2R2D -0.68 -14.1 -0.49 1.71e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11890956 chr21:40555474 PSMG1 -0.61 -13.85 -0.48 2.35e-38 Menarche (age at onset); BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs7524258 0.868 rs6577428 chr1:7314655 C/T cg07173049 chr1:7289937 CAMTA1 -0.48 -11.44 -0.41 1.11e-27 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs312273 0.806 rs1372542 chr12:41324876 A/G cg17827154 chr12:41323612 CNTN1 0.44 11.38 0.41 1.88e-27 Bipolar disorder; BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg22920501 chr2:26401640 FAM59B 0.65 11.45 0.41 9.48e-28 Gut microbiome composition (summer); BRCA cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.49e-52 Extrinsic epigenetic age acceleration; BRCA cis rs17401966 0.898 rs11587495 chr1:10448999 T/C cg03954927 chr1:10346856 KIF1B 0.47 14.45 0.5 3.86e-41 Hepatocellular carcinoma; BRCA cis rs4076764 0.801 rs12046142 chr1:163375247 G/A cg24596788 chr1:163392923 NA -0.35 -9.38 -0.35 1.17e-19 Motion sickness; BRCA cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg01475735 chr3:40494733 NA 0.49 10.27 0.38 5.34e-23 Renal cell carcinoma; BRCA cis rs7565124 1.000 rs67305930 chr2:20258070 G/C cg23821541 chr2:20251993 LAPTM4A 0.38 7.98 0.3 6.79e-15 Major depressive disorder; BRCA cis rs9309711 0.506 rs9284794 chr2:3492052 G/A cg10845886 chr2:3471009 TTC15 -0.49 -10.6 -0.39 2.82e-24 Neurofibrillary tangles; BRCA cis rs13082711 0.554 rs4973729 chr3:27390637 G/A cg02860705 chr3:27208620 NA 0.69 11.86 0.42 1.83e-29 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs16854884 0.538 rs61359084 chr3:143738362 T/C cg06585982 chr3:143692056 C3orf58 0.42 8.92 0.33 4.98e-18 Economic and political preferences (feminism/equality); BRCA cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg10883421 chr6:151773342 RMND1;C6orf211 0.58 13.65 0.48 1.98e-37 Menarche (age at onset); BRCA cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg26597838 chr10:835615 NA 1.3 21.86 0.65 1.6e-79 Eosinophil percentage of granulocytes; BRCA cis rs7301826 0.610 rs9668291 chr12:131296908 C/G cg11011512 chr12:131303247 STX2 0.5 12.95 0.46 3.24e-34 Plasma plasminogen activator levels; BRCA cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.52 -0.32 1.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg25358565 chr5:93447407 FAM172A 1.18 18.79 0.6 4.94e-63 Diabetic retinopathy; BRCA cis rs2204008 0.605 rs4608149 chr12:38132057 G/C cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4742903 0.527 rs55909255 chr9:106871788 T/C cg14250997 chr9:106856677 SMC2 0.28 8.36 0.31 3.82e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs4481887 0.927 rs7555310 chr1:248487638 A/G cg00666640 chr1:248458726 OR2T12 0.3 8.62 0.32 5.06e-17 Common traits (Other); BRCA cis rs12431939 0.947 rs56156789 chr14:51633899 C/G cg23942311 chr14:51606299 NA -0.46 -8.55 -0.32 8.92e-17 Cancer; BRCA cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg14019146 chr3:50243930 SLC38A3 -0.4 -9.84 -0.36 2.31e-21 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.837 rs34381557 chr12:38181983 T/C cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.59 0.32 6.82e-17 Glomerular filtration rate (creatinine); BRCA cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg21854759 chr1:92012499 NA -0.41 -9.7 -0.36 7.34e-21 Breast cancer; BRCA cis rs7605378 1.000 rs2346662 chr2:200679158 C/T cg23649088 chr2:200775458 C2orf69 0.49 9.91 0.37 1.2e-21 Osteoporosis; BRCA trans rs61931739 0.517 rs1486882 chr12:34025896 A/G cg13010199 chr12:38710504 ALG10B 0.48 9.31 0.35 2.02e-19 Morning vs. evening chronotype; BRCA cis rs12986413 1.000 rs12982593 chr19:2175891 C/A cg09261902 chr19:2140048 AP3D1 0.38 10.06 0.37 3.37e-22 Height; BRCA cis rs2204008 0.837 rs11612125 chr12:38213212 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg15103426 chr22:29168792 CCDC117 0.52 12.69 0.45 4.42e-33 Lymphocyte counts; BRCA cis rs7618501 0.602 rs10049087 chr3:50123417 A/G cg24110177 chr3:50126178 RBM5 0.37 10.13 0.37 1.8e-22 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.822 rs10151664 chr14:56029533 A/G cg01858014 chr14:56050164 KTN1 -0.52 -8.23 -0.31 1.05e-15 Putamen volume; BRCA cis rs13136331 0.532 rs1462368 chr4:88570799 A/G cg22416721 chr4:88570574 DMP1 -0.6 -14.9 -0.51 2.68e-43 Sitting height ratio; BRCA cis rs6088590 1.000 rs11696546 chr20:33452999 C/G cg06115741 chr20:33292138 TP53INP2 0.48 10.65 0.39 1.64e-24 Coronary artery disease; BRCA cis rs1595825 0.891 rs35817167 chr2:198718928 A/T cg19156104 chr2:198669113 PLCL1 -0.44 -8.18 -0.31 1.57e-15 Ulcerative colitis; BRCA cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.32 0.38 3.49e-23 Motion sickness; BRCA cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs6848389 chr4:120402622 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.99 -0.3 6.4e-15 Corneal astigmatism; BRCA trans rs10506458 1.000 rs73128779 chr12:63441852 T/G cg22491629 chr6:157744540 C6orf35 -0.65 -11.68 -0.42 1.07e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs10782582 0.609 rs5745547 chr1:76378275 G/C cg03433033 chr1:76189801 ACADM -0.39 -8.01 -0.3 5.44e-15 Daytime sleep phenotypes; BRCA cis rs10193935 1.000 rs10173107 chr2:42420302 A/T cg27598129 chr2:42591480 NA -0.96 -15.15 -0.51 1.57e-44 Colonoscopy-negative controls vs population controls; BRCA trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg15704280 chr7:45808275 SEPT13 -0.46 -8.84 -0.33 9.34e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs7587476 0.784 rs13032278 chr2:215698034 G/A cg04004882 chr2:215674386 BARD1 0.65 11.88 0.43 1.56e-29 Neuroblastoma; BRCA cis rs4363385 0.818 rs2651413 chr1:153012068 T/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs992157 0.560 rs6436048 chr2:219109033 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.43 9.54 0.35 2.87e-20 Colorectal cancer; BRCA cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg13271783 chr10:134563150 INPP5A -0.49 -10.03 -0.37 4.42e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs921968 0.565 rs6436083 chr2:219639719 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.93 -0.4 1.27e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg09033563 chr22:24373618 LOC391322 0.39 8.01 0.3 5.35e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs8114671 0.836 rs1885114 chr20:33577361 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -8.24 -0.31 1.01e-15 Height; BRCA trans rs8073060 0.559 rs72829925 chr17:34049778 C/A cg19694781 chr19:47549865 TMEM160 1.06 20.5 0.63 3.66e-72 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.85 0.39 2.74e-25 Bipolar disorder; BRCA cis rs12347191 0.500 rs1465965 chr9:100620326 C/T cg13688889 chr9:100608707 NA -0.49 -9.94 -0.37 9.4e-22 Orofacial clefts; BRCA cis rs11792861 0.816 rs3763643 chr9:111695607 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.91 0.3 1.11e-14 Menarche (age at onset); BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg08888203 chr3:10149979 C3orf24 0.62 11.71 0.42 8.19e-29 Alzheimer's disease; BRCA cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg08999081 chr20:33150536 PIGU 0.47 12.98 0.46 2.36e-34 Glomerular filtration rate (creatinine); BRCA cis rs7666738 0.830 rs17558193 chr4:99049593 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs921968 0.643 rs2278529 chr2:219502132 C/T cg02176678 chr2:219576539 TTLL4 0.42 11.27 0.41 5.52e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg11764359 chr7:65958608 NA -0.76 -17.52 -0.57 1.94e-56 Aortic root size; BRCA cis rs1348850 0.872 rs12991272 chr2:178457339 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 8.3 0.31 6.23e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg08027265 chr7:2291960 NA -0.36 -8.38 -0.31 3.38e-16 Bipolar disorder and schizophrenia; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg03188948 chr7:1209495 NA 0.9 14.22 0.49 4.47e-40 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.51 -0.32 1.19e-16 Monocyte percentage of white cells; BRCA cis rs875971 0.862 rs1968126 chr7:66057004 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.82 -0.3 2.21e-14 Aortic root size; BRCA cis rs3092073 0.624 rs11906879 chr20:44591324 C/T cg27529037 chr20:44575021 PCIF1 -0.37 -8.6 -0.32 6.24e-17 Intelligence (multi-trait analysis); BRCA cis rs561341 0.941 rs8081016 chr17:30331751 A/G cg00745463 chr17:30367425 LRRC37B -0.54 -8.86 -0.33 8.09e-18 Hip circumference adjusted for BMI; BRCA cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg23711669 chr6:146136114 FBXO30 -0.73 -15.58 -0.52 1.22e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs7789940 0.904 rs6948661 chr7:75961647 T/C cg10167463 chr7:75959203 YWHAG -0.44 -8.86 -0.33 7.66e-18 Multiple sclerosis; BRCA cis rs74181299 0.648 rs1050676 chr2:65310831 A/T cg05010058 chr2:65284262 CEP68 -0.29 -7.94 -0.3 9.38e-15 Pulse pressure; BRCA cis rs858239 0.896 rs1637193 chr7:23260251 G/T cg23682824 chr7:23144976 KLHL7 0.39 9.9 0.36 1.36e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs7903847 0.620 rs10882904 chr10:99115683 A/G cg08345082 chr10:99160200 RRP12 -0.28 -8.03 -0.3 4.59e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs7851660 0.527 rs7859751 chr9:100575888 C/T cg13688889 chr9:100608707 NA -0.53 -12.05 -0.43 2.77e-30 Strep throat; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.45 -0.59 2.85e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs10791323 0.572 rs10894755 chr11:133739685 C/T cg15485101 chr11:133734466 NA -0.37 -9.38 -0.35 1.13e-19 Childhood ear infection; BRCA cis rs10463316 0.862 rs7700650 chr5:150776473 C/T cg03212797 chr5:150827313 SLC36A1 -0.42 -8.32 -0.31 5.34e-16 Metabolite levels (Pyroglutamine); BRCA cis rs738321 0.757 rs5750546 chr22:38542499 C/T cg20207973 chr22:38506712 BAIAP2L2 0.38 9.25 0.34 3.3e-19 Breast cancer; BRCA cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg12386194 chr3:101231763 SENP7 0.63 12.27 0.44 3.32e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg21573476 chr21:45109991 RRP1B -0.49 -12.87 -0.45 7.35e-34 Coronary artery disease; BRCA cis rs10504073 0.584 rs11776843 chr8:49928449 C/T cg00325661 chr8:49890786 NA 0.5 14.52 0.5 1.66e-41 Blood metabolite ratios; BRCA cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg05623727 chr3:50126028 RBM5 0.38 9.11 0.34 1.01e-18 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg09177884 chr7:1199841 ZFAND2A -0.38 -8.76 -0.33 1.72e-17 Longevity;Endometriosis; BRCA cis rs738321 0.694 rs4821749 chr22:38542074 A/G cg25457927 chr22:38595422 NA -0.36 -12.61 -0.45 1.02e-32 Breast cancer; BRCA cis rs6963495 0.818 rs115609508 chr7:105163716 C/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7715811 0.956 rs5023693 chr5:13767129 T/C cg07548982 chr5:13769939 DNAH5 -0.41 -9.05 -0.34 1.75e-18 Subclinical atherosclerosis traits (other); BRCA cis rs7246657 0.598 rs10405372 chr19:37668775 A/C cg18154014 chr19:37997991 ZNF793 0.55 9.25 0.34 3.46e-19 Coronary artery calcification; BRCA cis rs6840360 0.615 rs10001603 chr4:152647577 T/A cg22705602 chr4:152727874 NA -0.37 -10.2 -0.37 9.7e-23 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.41 0.35 8.81e-20 Tonsillectomy; BRCA cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17401966 0.522 rs912962 chr1:10348712 G/T cg03954927 chr1:10346856 KIF1B -0.34 -10.06 -0.37 3.39e-22 Hepatocellular carcinoma; BRCA cis rs7301826 0.651 rs4759525 chr12:131316281 T/C cg11011512 chr12:131303247 STX2 0.52 13.68 0.48 1.44e-37 Plasma plasminogen activator levels; BRCA cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg02297831 chr4:17616191 MED28 0.36 8.17 0.31 1.64e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1401999 0.714 rs7646621 chr3:183640865 A/C cg01324343 chr3:183735012 ABCC5 -0.63 -15.24 -0.52 5.97e-45 Anterior chamber depth; BRCA cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.45 8.59 0.32 6.5e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs950169 0.545 rs4354897 chr15:84644971 T/C cg17507749 chr15:85114479 UBE2QP1 0.51 8.49 0.32 1.42e-16 Schizophrenia; BRCA cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg16325326 chr1:53192061 ZYG11B -0.71 -18.38 -0.59 6.85e-61 Monocyte count; BRCA cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg16482183 chr6:26056742 HIST1H1C -0.44 -9.11 -0.34 1.08e-18 Iron status biomarkers; BRCA cis rs2243480 0.901 rs34807232 chr7:65965133 G/A cg18252515 chr7:66147081 NA -1.07 -15.92 -0.53 2.69e-48 Diabetic kidney disease; BRCA cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg18876405 chr7:65276391 NA -0.49 -10.79 -0.39 4.93e-25 Aortic root size; BRCA cis rs6834538 0.597 rs2029211 chr4:113488134 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.41 9.78 0.36 3.89e-21 Free thyroxine concentration; BRCA cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg21724239 chr8:58056113 NA 0.45 7.98 0.3 6.83e-15 Developmental language disorder (linguistic errors); BRCA cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02475777 chr4:1388615 CRIPAK 0.61 12.02 0.43 3.84e-30 Longevity; BRCA cis rs7903847 0.642 rs11189180 chr10:99143529 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.6 -0.32 6.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs62402013 1 rs62402013 chr6:26915000 A/G cg12292205 chr6:26970375 C6orf41 0.72 16.29 0.54 3.86e-50 Schizophrenia; BRCA cis rs801193 0.660 rs974239 chr7:66213491 G/A cg12463550 chr7:65579703 CRCP 0.38 8.08 0.3 3.3e-15 Aortic root size; BRCA cis rs6570726 0.791 rs10872577 chr6:145900560 G/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg15112475 chr7:1198522 ZFAND2A -0.38 -8.49 -0.32 1.42e-16 Longevity;Endometriosis; BRCA cis rs2011503 1.000 rs2965194 chr19:19460702 C/T cg15839431 chr19:19639596 YJEFN3 0.41 8.96 0.33 3.58e-18 Bipolar disorder; BRCA cis rs7727544 0.582 rs7703009 chr5:131552385 C/G cg14196790 chr5:131705035 SLC22A5 0.37 9.06 0.34 1.59e-18 Blood metabolite levels; BRCA cis rs897984 0.574 rs11647284 chr16:31077335 G/A cg02466173 chr16:30829666 NA -0.4 -8.62 -0.32 5.21e-17 Dementia with Lewy bodies; BRCA cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg05340658 chr4:99064831 C4orf37 0.7 17.55 0.57 1.4e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg10057126 chr4:77819792 ANKRD56 0.65 14.87 0.51 3.66e-43 Emphysema distribution in smoking; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg16145915 chr7:1198662 ZFAND2A -0.66 -17.81 -0.58 6.38e-58 Longevity;Endometriosis; BRCA cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -10.46 -0.38 9.67e-24 Extrinsic epigenetic age acceleration; BRCA cis rs7762018 0.556 rs78233989 chr6:170102041 C/G cg19338460 chr6:170058176 WDR27 -0.75 -10.03 -0.37 4.55e-22 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs1975991 0.711 rs6809682 chr3:187968192 C/A cg15417654 chr3:187959138 LPP 0.32 8.17 0.31 1.62e-15 White matter integrity (bipolar disorder risk interaction); BRCA cis rs2243480 1.000 rs73142121 chr7:65311206 C/T cg18252515 chr7:66147081 NA -0.81 -11.34 -0.41 2.84e-27 Diabetic kidney disease; BRCA cis rs752010 1.000 rs6656183 chr1:42094025 A/G cg06885757 chr1:42089581 HIVEP3 0.27 9.6 0.36 1.75e-20 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9527 0.590 rs7898770 chr10:104756636 A/G cg04362960 chr10:104952993 NT5C2 -0.44 -10.29 -0.38 4.46e-23 Arsenic metabolism; BRCA cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9467773 0.967 rs9467775 chr6:26513435 G/A cg11502198 chr6:26597334 ABT1 0.47 9.47 0.35 5.19e-20 Intelligence (multi-trait analysis); BRCA cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg05665937 chr4:1216051 CTBP1 -0.38 -8.14 -0.31 2.05e-15 Obesity-related traits; BRCA cis rs17401966 1.000 rs17410793 chr1:10391886 A/G cg15208524 chr1:10270712 KIF1B 0.37 7.86 0.3 1.63e-14 Hepatocellular carcinoma; BRCA cis rs317689 0.513 rs529268 chr12:69687051 G/A cg20891283 chr12:69753455 YEATS4 0.48 11.18 0.4 1.28e-26 Response to diuretic therapy; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg02353165 chr6:42928485 GNMT 0.78 18.9 0.6 1.25e-63 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg18758796 chr5:131593413 PDLIM4 0.31 7.9 0.3 1.23e-14 Blood metabolite levels; BRCA cis rs7267979 1.000 rs6515651 chr20:25414539 T/G cg08601574 chr20:25228251 PYGB -0.34 -8.22 -0.31 1.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg11752832 chr7:134001865 SLC35B4 0.52 11.86 0.42 1.76e-29 Mean platelet volume; BRCA trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg00717180 chr2:96193071 NA -0.37 -10.22 -0.37 8.08e-23 Height; BRCA cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.67 0.5 3.45e-42 Motion sickness; BRCA trans rs61931739 0.534 rs11053016 chr12:34104372 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.23 0.34 3.94e-19 Morning vs. evening chronotype; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg03923535 chr7:1197113 ZFAND2A 0.4 7.9 0.3 1.24e-14 Longevity;Endometriosis; BRCA cis rs6089829 0.962 rs6122352 chr20:61668284 T/C cg08045932 chr20:61659980 NA 0.5 11.48 0.41 7.39e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs11716531 0.537 rs7626646 chr3:27268316 G/T cg02860705 chr3:27208620 NA 0.61 11.88 0.43 1.53e-29 Diastolic blood pressure; BRCA cis rs61990749 0.544 rs3759728 chr14:78230159 A/T cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.97 0.3 7.44e-15 Fibroblast growth factor basic levels; BRCA cis rs2985684 0.802 rs8015368 chr14:50020510 G/A cg04989706 chr14:50066350 PPIL5 -0.5 -9.95 -0.37 9.01e-22 Carotid intima media thickness; BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg00166722 chr3:10149974 C3orf24 0.67 13.44 0.47 1.83e-36 Alzheimer's disease; BRCA cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg01448562 chr3:133502909 NA -0.63 -14.91 -0.51 2.4e-43 Iron status biomarkers; BRCA trans rs4714291 0.775 rs2949019 chr6:40051200 C/T cg02267698 chr19:7991119 CTXN1 -0.45 -9.35 -0.35 1.46e-19 Strep throat; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg21747090 chr2:27597821 SNX17 -0.43 -9.27 -0.34 2.87e-19 Total body bone mineral density; BRCA cis rs1018836 0.923 rs7833025 chr8:91568470 G/C cg16814680 chr8:91681699 NA -0.64 -14.25 -0.49 3.37e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg00504896 chr12:9437009 LOC642846 -0.37 -8.02 -0.3 5.25e-15 Breast size; BRCA cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg27398817 chr8:82754497 SNX16 -0.46 -8.93 -0.33 4.45e-18 Diastolic blood pressure; BRCA cis rs7520050 0.966 rs785471 chr1:46518677 T/C cg24296786 chr1:45957014 TESK2 0.43 9.72 0.36 6.27e-21 Red blood cell count;Reticulocyte count; BRCA cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg16339924 chr4:17578868 LAP3 -0.56 -13.84 -0.48 2.82e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9914988 0.832 rs12946132 chr17:27157362 T/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.8 -0.33 1.25e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs372883 0.613 rs1153290 chr21:30687404 G/T cg24692254 chr21:30365293 RNF160 -0.39 -8.96 -0.33 3.54e-18 Pancreatic cancer; BRCA cis rs7666738 0.830 rs13144564 chr4:98939276 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1577917 0.958 rs884842 chr6:86680397 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.1 -0.43 1.73e-30 Response to antipsychotic treatment; BRCA cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg02527881 chr3:46936655 PTH1R 0.42 10.17 0.37 1.3e-22 Birth weight; BRCA cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg26384229 chr12:38710491 ALG10B -0.8 -21.43 -0.65 3.27e-77 Heart rate; BRCA cis rs1865721 0.804 rs72977816 chr18:73146779 A/T cg26385618 chr18:73139727 C18orf62 -0.44 -10.79 -0.39 4.95e-25 Intelligence; BRCA cis rs9790314 0.936 rs466399 chr3:161091194 G/T cg04691961 chr3:161091175 C3orf57 -0.63 -16.6 -0.55 9.68e-52 Morning vs. evening chronotype; BRCA cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg11168104 chr5:1857477 NA -0.36 -9.5 -0.35 4.16e-20 Cardiovascular disease risk factors; BRCA cis rs3772130 1.000 rs11719458 chr3:121382005 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.22 0.34 4.11e-19 Cognitive performance; BRCA cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00934597 chr7:893267 UNC84A -0.54 -11.93 -0.43 9.43e-30 Perceived unattractiveness to mosquitoes; BRCA cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg05283184 chr6:79620031 NA -0.43 -11.37 -0.41 2.08e-27 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg26516362 chr5:178986906 RUFY1 -0.44 -12.8 -0.45 1.42e-33 Lung cancer; BRCA cis rs8114671 0.562 rs6087644 chr20:33480917 G/C cg24642439 chr20:33292090 TP53INP2 0.41 7.86 0.3 1.65e-14 Height; BRCA cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg11752832 chr7:134001865 SLC35B4 0.52 13.39 0.47 3.12e-36 Mean platelet volume; BRCA cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg19748678 chr4:122722346 EXOSC9 0.74 16.15 0.54 1.8e-49 Type 2 diabetes; BRCA cis rs9814567 0.806 rs4245904 chr3:134321808 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11051970 0.636 rs10844198 chr12:32563479 G/T cg24626660 chr12:32551988 NA 0.31 9.26 0.34 2.98e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg04398451 chr17:18023971 MYO15A 0.74 16.12 0.54 2.69e-49 Total body bone mineral density; BRCA cis rs459571 0.959 rs465535 chr9:136910905 C/T cg13789015 chr9:136890014 NCRNA00094 0.57 11.86 0.42 1.9e-29 Platelet distribution width; BRCA trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -16.63 -0.55 7.15e-52 Intelligence (multi-trait analysis); BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg18538332 chr22:24372958 LOC391322 -0.49 -11.62 -0.42 1.98e-28 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs5758511 0.680 rs5758688 chr22:42662501 T/C cg00645731 chr22:42541494 CYP2D7P1 0.57 10.85 0.39 2.67e-25 Birth weight; BRCA cis rs1506403 0.685 rs10281506 chr7:142823928 C/T cg15652212 chr7:142981776 TMEM139 0.43 8.27 0.31 7.95e-16 Cancer; BRCA cis rs72781680 0.898 rs79023848 chr2:24038174 C/A cg08917208 chr2:24149416 ATAD2B 1.07 14.93 0.51 1.89e-43 Lymphocyte counts; BRCA cis rs910316 0.967 rs175502 chr14:75533679 A/G cg23033748 chr14:75592666 NEK9 -0.42 -10.27 -0.38 5.49e-23 Height; BRCA cis rs10046574 0.561 rs9656458 chr7:135202300 G/A cg27474649 chr7:135195673 CNOT4 0.66 11.04 0.4 4.84e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg00531865 chr16:30841666 NA -0.38 -9.02 -0.34 2.25e-18 Dementia with Lewy bodies; BRCA cis rs875971 0.660 rs12698534 chr7:65986845 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.07 0.3 3.56e-15 Aortic root size; BRCA cis rs2301436 0.512 rs6925969 chr6:167501738 C/A cg07741184 chr6:167504864 NA 0.35 10.37 0.38 2.21e-23 Crohn's disease; BRCA cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg11941060 chr3:133502564 NA -0.51 -12.16 -0.43 9.28e-31 Iron status biomarkers; BRCA cis rs6684514 1.000 rs10908499 chr1:156279176 G/C cg16558208 chr1:156270281 VHLL 0.34 8.07 0.3 3.48e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg18225595 chr11:63971243 STIP1 0.51 9.45 0.35 6.24e-20 Mean platelet volume; BRCA trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg03929089 chr4:120376271 NA -0.66 -13.01 -0.46 1.68e-34 Coronary artery disease; BRCA cis rs1371614 0.523 rs7585127 chr2:27179371 A/G cg00617064 chr2:27272375 NA -0.31 -7.87 -0.3 1.53e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg04025307 chr7:1156635 C7orf50 0.38 9.1 0.34 1.11e-18 Longevity;Endometriosis; BRCA cis rs7582720 1.000 rs72934715 chr2:203713280 C/A cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 12.51 0.44 2.8e-32 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs9811920 0.516 rs793486 chr3:99493165 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.86 -0.36 1.97e-21 Axial length; BRCA cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg14196790 chr5:131705035 SLC22A5 0.31 8.03 0.3 4.82e-15 Blood metabolite levels; BRCA cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg08917208 chr2:24149416 ATAD2B 0.9 12.65 0.45 6.89e-33 Lymphocyte counts; BRCA cis rs72781680 0.898 rs72796154 chr2:23933839 G/A cg20701182 chr2:24300061 SF3B14 0.62 8.87 0.33 7.2e-18 Lymphocyte counts; BRCA cis rs1401999 1.000 rs6805913 chr3:183662924 T/G cg01324343 chr3:183735012 ABCC5 0.83 20.96 0.64 1.25e-74 Anterior chamber depth; BRCA cis rs1011018 0.628 rs7787807 chr7:139433190 T/C cg03224163 chr7:139420300 HIPK2 -0.54 -9.14 -0.34 8.03e-19 Systolic blood pressure; BRCA cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg23711669 chr6:146136114 FBXO30 0.8 19.48 0.61 1.05e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs992157 0.560 rs1514132 chr2:219084082 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.24 -0.34 3.62e-19 Colorectal cancer; BRCA cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg00531865 chr16:30841666 NA 0.35 8.09 0.3 3.03e-15 Dementia with Lewy bodies; BRCA cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.52 -11.3 -0.41 4.13e-27 IgG glycosylation; BRCA cis rs35110281 0.693 rs3819161 chr21:45092653 A/G cg04455712 chr21:45112962 RRP1B 0.47 11.32 0.41 3.31e-27 Mean corpuscular volume; BRCA cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg18230493 chr5:56204884 C5orf35 -0.41 -8.18 -0.31 1.55e-15 Coronary artery disease; BRCA cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg24675658 chr1:53192096 ZYG11B -0.57 -11.36 -0.41 2.23e-27 Monocyte count; BRCA cis rs7786808 0.653 rs7810861 chr7:158212633 G/A cg01191920 chr7:158217561 PTPRN2 -0.36 -8.59 -0.32 6.65e-17 Obesity-related traits; BRCA cis rs7267979 0.966 rs2424714 chr20:25418681 T/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2204008 0.583 rs12820907 chr12:37990931 T/C cg26384229 chr12:38710491 ALG10B 0.67 15.37 0.52 1.35e-45 Bladder cancer; BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg25036284 chr2:26402008 FAM59B -0.63 -10.58 -0.39 3.38e-24 Gut microbiome composition (summer); BRCA trans rs7824557 0.767 rs6991606 chr8:11176159 G/A cg08975724 chr8:8085496 FLJ10661 0.44 8.06 0.3 3.67e-15 Retinal vascular caliber; BRCA cis rs6582630 0.615 rs11182380 chr12:38511735 G/T cg26384229 chr12:38710491 ALG10B -0.43 -10.05 -0.37 3.79e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.27 -0.38 5.39e-23 Psoriasis; BRCA cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg02659138 chr7:134003124 SLC35B4 0.32 10.01 0.37 5.17e-22 Mean platelet volume; BRCA cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg01283332 chr5:1856932 NA -0.34 -8.37 -0.31 3.52e-16 Cardiovascular disease risk factors; BRCA cis rs4481887 0.854 rs4534423 chr1:248474993 G/C cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.46e-16 Common traits (Other); BRCA cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.25 -0.31 8.87e-16 Developmental language disorder (linguistic errors); BRCA cis rs2072499 0.833 rs2251636 chr1:156202809 G/C cg24450063 chr1:156163899 SLC25A44 0.92 25.16 0.71 1.28e-97 Testicular germ cell tumor; BRCA cis rs11971779 0.616 rs6944244 chr7:139051186 T/C cg07862535 chr7:139043722 LUC7L2 0.38 10.28 0.38 4.63e-23 Diisocyanate-induced asthma; BRCA cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg08392591 chr16:89556376 ANKRD11 0.38 8.94 0.33 4.1e-18 Multiple myeloma (IgH translocation); BRCA cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg13010199 chr12:38710504 ALG10B 0.55 12.23 0.44 4.72e-31 Heart rate; BRCA cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg08999081 chr20:33150536 PIGU 0.47 12.98 0.46 2.33e-34 Glomerular filtration rate (creatinine); BRCA cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg02931644 chr1:25747376 RHCE -0.4 -11.01 -0.4 5.96e-26 Plateletcrit;Mean corpuscular volume; BRCA trans rs783540 0.967 rs1259183 chr15:83279433 C/T cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.5 -0.32 1.29e-16 Schizophrenia; BRCA cis rs12477438 0.501 rs6751927 chr2:99740175 T/C cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.34e-23 Chronic sinus infection; BRCA cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.96e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7208859 0.623 rs11657662 chr17:29076347 A/G cg13385521 chr17:29058706 SUZ12P -0.76 -11.27 -0.41 5.26e-27 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs910316 0.737 rs175080 chr14:75513828 G/A cg11812906 chr14:75593930 NEK9 -0.61 -13.9 -0.48 1.49e-38 Height; BRCA cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg24060327 chr5:131705240 SLC22A5 -0.49 -10.39 -0.38 1.73e-23 Blood metabolite levels; BRCA cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.7 14.49 0.5 2.46e-41 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg11366901 chr6:160182831 ACAT2 0.72 13.6 0.47 3.58e-37 Age-related macular degeneration (geographic atrophy); BRCA cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg20203395 chr5:56204925 C5orf35 -0.49 -10.31 -0.38 3.61e-23 Initial pursuit acceleration; BRCA cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.8e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10883723 0.775 rs7917158 chr10:104246471 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.86 0.62 1.07e-68 Allergic disease (asthma, hay fever or eczema); BRCA trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21659725 chr3:3221576 CRBN -0.49 -10.32 -0.38 3.47e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg21951975 chr1:209979733 IRF6 0.39 8.23 0.31 1.09e-15 Cleft lip with or without cleft palate; BRCA cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg27286337 chr10:134555280 INPP5A 0.76 12.48 0.44 3.81e-32 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2749592 0.513 rs9417249 chr10:37837155 C/T cg25427524 chr10:38739819 LOC399744 0.47 9.96 0.37 8.3e-22 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6938 0.618 rs11857695 chr15:75165751 G/T cg13906792 chr15:75199810 C15orf17 -0.41 -9.56 -0.35 2.54e-20 Breast cancer; BRCA cis rs688020 1.000 rs673500 chr7:4229445 C/G cg02004499 chr7:4244250 SDK1 -0.42 -8.87 -0.33 7.45e-18 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; BRCA cis rs1878931 0.501 rs9635563 chr16:3416940 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 12.07 0.43 2.27e-30 Body mass index (adult); BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg27170947 chr2:26402098 FAM59B -0.94 -16.89 -0.56 3.36e-53 Gut microbiome composition (summer); BRCA cis rs2204008 0.729 rs114133083 chr12:38182923 G/C cg26384229 chr12:38710491 ALG10B -0.45 -10.29 -0.38 4.25e-23 Bladder cancer; BRCA cis rs738322 0.804 rs4821742 chr22:38514839 T/C cg25457927 chr22:38595422 NA -0.31 -10.86 -0.39 2.51e-25 Cutaneous nevi; BRCA cis rs2625529 0.824 rs11072346 chr15:72400434 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.47 -0.57 3.5e-56 Red blood cell count; BRCA cis rs1865760 0.534 rs72834629 chr6:26023032 C/T cg16482183 chr6:26056742 HIST1H1C 0.66 13.55 0.47 5.86e-37 Height; BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg26314531 chr2:26401878 FAM59B -0.62 -10.94 -0.4 1.17e-25 Gut microbiome composition (summer); BRCA cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg06552810 chr11:31128660 NA -0.4 -8.79 -0.33 1.36e-17 Red blood cell count; BRCA cis rs7829975 0.573 rs7842359 chr8:8797078 T/G cg08975724 chr8:8085496 FLJ10661 -0.41 -8.81 -0.33 1.18e-17 Mood instability; BRCA cis rs10911232 0.507 rs4652763 chr1:182994084 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.48e-52 Hypertriglyceridemia; BRCA cis rs4891159 0.548 rs10782013 chr18:74128348 C/T cg24786174 chr18:74118243 ZNF516 0.84 25.35 0.71 1.24e-98 Longevity; BRCA cis rs7264396 0.570 rs1970576 chr20:34336720 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.74 -15.93 -0.53 2.22e-48 Total cholesterol levels; BRCA cis rs6138458 1.000 rs227651 chr20:24929834 A/G cg06937882 chr20:24974362 C20orf3 -0.47 -8.88 -0.33 6.66e-18 Blood protein levels; BRCA cis rs34172651 0.517 rs2547040 chr16:24736408 G/C cg04756594 chr16:24857601 SLC5A11 -0.53 -11.87 -0.42 1.72e-29 Intelligence (multi-trait analysis); BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 9.16 0.34 7.13e-19 Bipolar disorder; BRCA cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg17971929 chr21:40555470 PSMG1 0.52 11.66 0.42 1.23e-28 Cognitive function; BRCA cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg11057378 chr10:81107060 PPIF -0.43 -10.48 -0.38 7.77e-24 Height; BRCA cis rs9399137 0.507 rs35571217 chr6:135290355 T/C cg22676075 chr6:135203613 NA 0.44 8.7 0.33 2.91e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg14019146 chr3:50243930 SLC38A3 -0.41 -9.77 -0.36 4.25e-21 Body mass index; BRCA cis rs13064411 0.518 rs9852703 chr3:113189368 C/T cg18753928 chr3:113234510 CCDC52 0.39 8.82 0.33 1.1e-17 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9467711 0.606 rs9379900 chr6:26603811 A/C cg12826209 chr6:26865740 GUSBL1 0.64 8.42 0.32 2.43e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs2204008 0.515 rs11495471 chr12:38027178 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.91 0.56 2.6e-53 Bladder cancer; BRCA cis rs66573146 1.000 rs6838250 chr4:6973184 C/G cg00086871 chr4:6988644 TBC1D14 0.88 10.8 0.39 4.32e-25 Granulocyte percentage of myeloid white cells; BRCA trans rs11098499 0.697 rs4560394 chr4:120313435 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.97 0.3 7.55e-15 Corneal astigmatism; BRCA cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 8.67 0.32 3.58e-17 Personality dimensions; BRCA cis rs3845702 1.000 rs262279 chr2:180869145 G/A cg01881094 chr2:180872142 CWC22 0.65 13.58 0.47 4.19e-37 Schizophrenia; BRCA cis rs72949976 0.646 rs1441170 chr2:214033563 A/G cg08319019 chr2:214017104 IKZF2 -0.43 -9.3 -0.35 2.12e-19 Lung cancer;Squamous cell lung carcinoma; BRCA cis rs7584330 0.554 rs77956735 chr2:238399130 C/T cg08992911 chr2:238395768 MLPH 0.6 10.16 0.37 1.38e-22 Prostate cancer; BRCA trans rs208520 0.874 rs208481 chr6:66922636 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.3 -0.54 3.22e-50 Exhaled nitric oxide output; BRCA cis rs7552404 0.824 rs1251077 chr1:76189745 C/G cg10523679 chr1:76189770 ACADM -0.92 -26.97 -0.73 1.53e-107 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7927771 0.524 rs3758655 chr11:47703943 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.52 0.35 3.42e-20 Subjective well-being; BRCA cis rs9818758 0.607 rs11706189 chr3:49210833 C/A cg00383909 chr3:49044727 WDR6 0.75 12.5 0.44 3e-32 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.868 rs2427885 chr2:61816777 A/G cg15711740 chr2:61764176 XPO1 -0.56 -14.38 -0.49 7.74e-41 Tuberculosis; BRCA cis rs2153535 0.580 rs9379215 chr6:8481225 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 7.17e-41 Motion sickness; BRCA trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.77 0.42 4.25e-29 Corneal astigmatism; BRCA cis rs17401966 0.931 rs17034821 chr1:10414645 A/G cg19773385 chr1:10388646 KIF1B -0.38 -8.27 -0.31 7.81e-16 Hepatocellular carcinoma; BRCA trans rs4714291 0.963 rs1743969 chr6:40096918 A/G cg02267698 chr19:7991119 CTXN1 0.41 8.14 0.31 2.1e-15 Strep throat; BRCA cis rs2576037 0.796 rs2576043 chr18:44573476 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.14 0.31 2.07e-15 Personality dimensions; BRCA cis rs6740322 0.644 rs11690918 chr2:43474112 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -11.86 -0.42 1.78e-29 Coronary artery disease; BRCA cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs3820928 0.874 rs12614648 chr2:227785535 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.84 -0.33 8.95e-18 Pulmonary function; BRCA cis rs7903847 0.642 rs7903562 chr10:99154782 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.9 -0.33 5.68e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs6840360 0.615 rs56319216 chr4:152463716 C/T cg25486957 chr4:152246857 NA -0.36 -7.9 -0.3 1.26e-14 Intelligence (multi-trait analysis); BRCA cis rs597539 0.652 rs488363 chr11:68658298 C/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.25 0.59 3.36e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs736408 0.812 rs2071506 chr3:52826276 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 8.51 0.32 1.23e-16 Bipolar disorder; BRCA cis rs8141529 0.702 rs469990 chr22:29304200 A/T cg02153584 chr22:29168773 CCDC117 0.5 10.94 0.4 1.2e-25 Lymphocyte counts; BRCA cis rs875971 0.660 rs10215132 chr7:66054406 C/A cg18876405 chr7:65276391 NA -0.63 -15.45 -0.52 5.27e-46 Aortic root size; BRCA cis rs7020830 0.898 rs13290794 chr9:37183628 C/T cg14294708 chr9:37120828 ZCCHC7 1.15 37.07 0.83 2.14e-161 Schizophrenia; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.37e-15 Total body bone mineral density; BRCA cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg18446336 chr7:2847575 GNA12 -0.34 -8.23 -0.31 1.03e-15 Height; BRCA trans rs57046232 0.552 rs932828 chr20:6340080 G/A cg21095983 chr6:86352623 SYNCRIP 0.37 7.84 0.3 1.88e-14 Colorectal cancer; BRCA cis rs10484885 0.887 rs2273246 chr6:90453263 A/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -10.97 -0.4 8.69e-26 QRS interval (sulfonylurea treatment interaction); BRCA cis rs34779708 0.966 rs7913615 chr10:35422957 T/G cg03585969 chr10:35415529 CREM 0.54 11.17 0.4 1.37e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17818399 0.926 rs1378764 chr2:46839681 C/T cg02822958 chr2:46747628 ATP6V1E2 0.55 9.92 0.37 1.13e-21 Height; BRCA cis rs13064411 0.542 rs9846539 chr3:113228688 A/G cg18753928 chr3:113234510 CCDC52 -0.46 -9.82 -0.36 2.66e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7100689 0.622 rs1890890 chr10:82090643 A/T cg01528321 chr10:82214614 TSPAN14 0.81 17.28 0.56 3.71e-55 Post bronchodilator FEV1; BRCA cis rs11227306 0.902 rs625652 chr11:65641931 T/A cg26695010 chr11:65641043 EFEMP2 0.36 7.91 0.3 1.13e-14 DNA methylation (variation); BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg00814883 chr7:100076585 TSC22D4 -0.54 -11.48 -0.41 7.18e-28 Platelet count; BRCA cis rs61861422 0.516 rs12412216 chr10:134393338 C/T cg20090690 chr10:134436459 INPP5A 0.59 10.87 0.4 2.28e-25 Primary sclerosing cholangitis; BRCA cis rs6840360 0.615 rs4696266 chr4:152463421 A/G cg22705602 chr4:152727874 NA -0.32 -8.02 -0.3 5.2e-15 Intelligence (multi-trait analysis); BRCA cis rs679087 1.000 rs302317 chr12:29921443 G/A cg14258853 chr12:29935411 TMTC1 -0.43 -9.02 -0.34 2.2e-18 Schizophrenia; BRCA cis rs6089829 0.962 rs2314130 chr20:61665129 G/T cg08564027 chr20:61660810 NA 0.85 22.9 0.67 3.47e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs13315871 0.929 rs7643185 chr3:58311158 A/C cg20936604 chr3:58311152 NA 0.56 8.99 0.34 2.69e-18 Cholesterol, total; BRCA cis rs2991971 0.810 rs12738318 chr1:45929589 A/G cg24296786 chr1:45957014 TESK2 -0.55 -12.48 -0.44 3.66e-32 High light scatter reticulocyte count; BRCA cis rs875971 0.545 rs10261710 chr7:65714189 T/A cg11764359 chr7:65958608 NA 0.65 11.01 0.4 6.09e-26 Aortic root size; BRCA cis rs6542838 0.641 rs13005124 chr2:99527680 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -9.96 -0.37 8.21e-22 Fear of minor pain; BRCA cis rs2806561 0.704 rs2806570 chr1:23527005 C/T cg12483005 chr1:23474871 LUZP1 -0.47 -10.42 -0.38 1.33e-23 Height; BRCA cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg08645402 chr16:4508243 NA 0.39 9.14 0.34 8.36e-19 Schizophrenia; BRCA cis rs2070488 0.775 rs4679066 chr3:38568527 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.73 -0.53 2.29e-47 Electrocardiographic conduction measures; BRCA cis rs13064411 0.518 rs6769604 chr3:113185064 A/G cg18753928 chr3:113234510 CCDC52 -0.4 -8.97 -0.33 3.33e-18 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg22337977 chr21:31811175 KRTAP15-1 0.33 7.87 0.3 1.55e-14 HDL cholesterol; BRCA cis rs11716531 0.574 rs13075192 chr3:27279235 C/T cg02860705 chr3:27208620 NA 0.59 11.45 0.41 9.6e-28 Diastolic blood pressure; BRCA cis rs7395581 0.959 rs7129661 chr11:47268550 T/G cg25783544 chr11:47291846 MADD 0.41 9.09 0.34 1.24e-18 HDL cholesterol; BRCA cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg13256891 chr4:100009986 ADH5 -0.54 -12.47 -0.44 4.15e-32 Alcohol dependence; BRCA cis rs9400271 0.632 rs9374072 chr6:109591586 A/G cg21918786 chr6:109611834 NA -0.32 -8.08 -0.3 3.17e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.4 8.4 0.32 2.97e-16 Ulcerative colitis; BRCA cis rs7523050 0.643 rs35885176 chr1:109401868 G/A cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg21535942 chr1:75199100 CRYZ;TYW3 -0.43 -8.33 -0.31 4.78e-16 Resistin levels; BRCA cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg02891314 chr5:179741120 GFPT2 -0.64 -12.85 -0.45 9.21e-34 Height; BRCA cis rs6976053 0.518 rs314358 chr7:100410657 A/G cg03098644 chr7:100410630 EPHB4 -0.44 -8.9 -0.33 5.89e-18 Plasminogen activator inhibitor type 1 levels (PAI-1); BRCA trans rs1493916 0.837 rs4992177 chr18:31407020 C/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.48 -0.32 1.55e-16 Life satisfaction; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.61 -13.1 -0.46 6.7e-35 Lymphocyte counts; BRCA cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.53e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs12586317 0.547 rs116499019 chr14:35441931 T/C cg16230307 chr14:35515116 FAM177A1 0.74 15.5 0.52 3.27e-46 Psoriasis; BRCA cis rs10927875 0.557 rs1572381 chr1:16344494 G/A cg06159980 chr1:16340746 HSPB7 -0.38 -8.75 -0.33 1.92e-17 Dilated cardiomyopathy; BRCA cis rs13102973 0.965 rs4437307 chr4:135861598 C/T cg14419869 chr4:135874104 NA -0.58 -12.85 -0.45 8.58e-34 Subjective well-being; BRCA trans rs1005277 0.579 rs2474594 chr10:38426661 G/C cg23533926 chr12:111358616 MYL2 -0.41 -8.51 -0.32 1.2e-16 Extrinsic epigenetic age acceleration; BRCA cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.58 -9.72 -0.36 6.47e-21 Schizophrenia; BRCA cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.0 -0.34 2.54e-18 Alzheimer's disease (late onset); BRCA cis rs10927875 0.541 rs1763607 chr1:16337509 G/A cg22431228 chr1:16359049 CLCNKA -0.42 -9.51 -0.35 3.89e-20 Dilated cardiomyopathy; BRCA cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg06618935 chr21:46677482 NA -0.34 -8.1 -0.31 2.84e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9467773 0.587 rs12214031 chr6:26376628 T/C cg09904177 chr6:26538194 HMGN4 -0.31 -8.36 -0.31 3.81e-16 Intelligence (multi-trait analysis); BRCA cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg18200150 chr17:30822561 MYO1D 0.35 9.04 0.34 1.81e-18 Schizophrenia; BRCA trans rs1941687 0.527 rs6507059 chr18:31303643 A/G cg27147174 chr7:100797783 AP1S1 -0.47 -9.01 -0.34 2.42e-18 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs826838 0.616 rs10880738 chr12:38617762 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.14 -0.37 1.63e-22 Heart rate; BRCA cis rs113835537 0.597 rs4576 chr11:66331000 A/G cg24851651 chr11:66362959 CCS 0.45 8.64 0.32 4.32e-17 Airway imaging phenotypes; BRCA cis rs36051895 0.559 rs72701680 chr9:5207294 A/T cg02405213 chr9:5042618 JAK2 -0.43 -8.09 -0.3 3.02e-15 Pediatric autoimmune diseases; BRCA cis rs4409675 0.576 rs6660899 chr1:28214281 G/C cg23691781 chr1:28212827 C1orf38 0.32 10.73 0.39 7.96e-25 Corneal astigmatism; BRCA trans rs2204008 0.777 rs2387813 chr12:38382091 A/C cg06521331 chr12:34319734 NA -0.43 -8.13 -0.31 2.22e-15 Bladder cancer; BRCA cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03934478 chr11:495069 RNH1 -0.79 -11.39 -0.41 1.64e-27 Body mass index; BRCA cis rs950776 0.616 rs495090 chr15:78870003 A/G cg06917634 chr15:78832804 PSMA4 -0.55 -11.98 -0.43 5.61e-30 Sudden cardiac arrest; BRCA cis rs6565180 0.888 rs12447833 chr16:30390314 T/C cg17640201 chr16:30407289 ZNF48 0.76 16.36 0.54 1.59e-50 Tonsillectomy; BRCA cis rs1476670 0.683 rs2057967 chr1:44515446 T/C cg09470012 chr1:44509516 NA 0.4 9.02 0.34 2.21e-18 Eotaxin levels; BRCA cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.55 -0.32 8.79e-17 Developmental language disorder (linguistic errors); BRCA cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg06671706 chr8:8559999 CLDN23 0.44 8.72 0.33 2.42e-17 Obesity-related traits; BRCA cis rs3771570 1.000 rs56222556 chr2:242364119 G/A cg21155796 chr2:242212141 HDLBP 0.61 9.27 0.34 2.73e-19 Prostate cancer; BRCA cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 -0.49 -11.01 -0.4 6.47e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg02503808 chr4:7069936 GRPEL1 0.38 8.62 0.32 5.14e-17 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; BRCA cis rs9463078 0.809 rs6937317 chr6:45203918 T/C cg25276700 chr6:44698697 NA -0.36 -8.01 -0.3 5.54e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg12564285 chr5:131593104 PDLIM4 -0.35 -7.83 -0.3 2.07e-14 Breast cancer; BRCA cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs9400271 0.632 rs4427037 chr6:109585612 G/C cg01475377 chr6:109611718 NA -0.43 -10.3 -0.38 4.21e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs870825 0.616 rs7682677 chr4:185640717 C/G cg04058563 chr4:185651563 MLF1IP 0.76 17.1 0.56 2.99e-54 Blood protein levels; BRCA cis rs2880765 0.566 rs11630381 chr15:86012503 A/G cg10818794 chr15:86012489 AKAP13 -0.41 -11.07 -0.4 3.46e-26 Coronary artery disease; BRCA cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.22 0.31 1.13e-15 Cognitive ability; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg04166393 chr7:2884313 GNA12 0.48 9.15 0.34 7.36e-19 Height; BRCA cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.46e-15 Aortic root size; BRCA cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11644478 chr21:40555479 PSMG1 -0.66 -14.28 -0.49 2.46e-40 Cognitive function; BRCA cis rs6748734 0.817 rs10182575 chr2:241806690 C/T cg04034577 chr2:241836375 C2orf54 -0.5 -12.59 -0.45 1.21e-32 Urinary metabolites; BRCA cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.8e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs4689592 0.523 rs3857179 chr4:7070496 T/A cg07817883 chr1:32538562 TMEM39B -0.44 -8.48 -0.32 1.54e-16 Monocyte percentage of white cells; BRCA cis rs7044106 0.791 rs3904196 chr9:123480369 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 14.95 0.51 1.43e-43 Hip circumference adjusted for BMI; BRCA cis rs10771431 0.597 rs10843142 chr12:9357502 A/G cg08997352 chr12:9597637 DDX12 -0.54 -10.35 -0.38 2.57e-23 Breast size; BRCA cis rs3008870 0.755 rs2755243 chr1:67482783 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.66 0.48 1.83e-37 Lymphocyte percentage of white cells; BRCA trans rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg05623727 chr3:50126028 RBM5 -0.41 -9.65 -0.36 1.2e-20 Intelligence (multi-trait analysis); BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg21548813 chr6:291882 DUSP22 0.57 12.14 0.43 1.21e-30 Menopause (age at onset); BRCA cis rs4302748 0.862 rs74301277 chr7:36184831 C/G cg24442661 chr7:36192818 EEPD1 0.48 8.81 0.33 1.2e-17 Platelet count; BRCA cis rs6700896 0.931 rs4655585 chr1:66155627 T/C cg04111102 chr1:66153794 NA 0.34 8.23 0.31 1.07e-15 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6987853 0.787 rs2923402 chr8:42445400 G/A cg09913449 chr8:42400586 C8orf40 0.38 7.94 0.3 9.16e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs4268898 0.662 rs9917355 chr2:24433400 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.28 0.31 7.42e-16 Asthma; BRCA cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg07389463 chr12:132296394 NA -0.49 -13.31 -0.47 7.23e-36 Migraine; BRCA cis rs559928 1.000 rs72926046 chr11:64143387 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 9.65 0.36 1.21e-20 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs7582180 0.629 rs6736576 chr2:100950854 C/T cg14675211 chr2:100938903 LONRF2 0.44 10.11 0.37 2.18e-22 Intelligence (multi-trait analysis); BRCA cis rs514406 0.760 rs475969 chr1:53292607 T/A cg27535305 chr1:53392650 SCP2 -0.4 -9.63 -0.36 1.37e-20 Monocyte count; BRCA cis rs4566357 0.615 rs12328876 chr2:227918899 G/T cg05526886 chr2:227700861 RHBDD1 -0.4 -8.07 -0.3 3.48e-15 Coronary artery disease; BRCA cis rs3733585 0.673 rs6843873 chr4:9958788 A/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.59 -0.39 2.91e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17685 0.623 rs7782808 chr7:75768645 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9811920 0.838 rs12488245 chr3:99835254 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 12.89 0.45 5.97e-34 Axial length; BRCA cis rs7267979 1.000 rs4815418 chr20:25382211 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.09 -0.34 1.23e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9859260 0.744 rs557527 chr3:195780709 G/A cg12923728 chr3:195709715 SDHAP1 0.38 7.84 0.3 1.94e-14 Mean corpuscular volume; BRCA cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.07e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10193935 0.901 rs10201586 chr2:42622594 C/G cg27598129 chr2:42591480 NA -0.79 -13.33 -0.47 6.13e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs11792861 0.926 rs56899598 chr9:111867271 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.06 0.3 3.8e-15 Menarche (age at onset); BRCA cis rs909002 0.925 rs4949455 chr1:32114793 C/T cg13919466 chr1:32135498 COL16A1 -0.24 -8.12 -0.31 2.43e-15 Intelligence (multi-trait analysis); BRCA cis rs1691799 0.867 rs1039056 chr12:66760391 C/T cg16791601 chr12:66731901 HELB -0.65 -17.61 -0.57 7.24e-57 White blood cell count (basophil); BRCA cis rs793571 0.523 rs7161889 chr15:58983425 C/G cg05156742 chr15:59063176 FAM63B 0.56 11.43 0.41 1.15e-27 Schizophrenia; BRCA cis rs10189230 0.935 rs1864461 chr2:222347615 A/G cg14652038 chr2:222343519 EPHA4 0.48 13.27 0.46 1.11e-35 Urate levels in lean individuals; BRCA cis rs9527 0.590 rs7894959 chr10:104756182 C/T cg04362960 chr10:104952993 NT5C2 0.41 9.51 0.35 3.67e-20 Arsenic metabolism; BRCA cis rs7927592 0.913 rs11228268 chr11:68287447 A/T cg20283391 chr11:68216788 NA -0.48 -9.32 -0.35 1.88e-19 Total body bone mineral density; BRCA cis rs1707322 0.752 rs11211169 chr1:46166709 A/G cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12200782 0.530 rs6929908 chr6:26555289 C/A cg09904177 chr6:26538194 HMGN4 0.37 7.99 0.3 6.52e-15 Small cell lung carcinoma; BRCA cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg13770153 chr20:60521292 NA 0.56 11.82 0.42 2.78e-29 Body mass index; BRCA cis rs13136331 0.680 rs2732178 chr4:88654589 T/C cg12990093 chr4:88570587 DMP1 -0.4 -8.17 -0.31 1.61e-15 Sitting height ratio; BRCA cis rs2289583 0.597 rs12148708 chr15:75384397 G/A cg14664628 chr15:75095509 CSK 0.39 9.14 0.34 8.45e-19 Systemic lupus erythematosus; BRCA cis rs10267417 0.603 rs1557773 chr7:19908586 A/G cg07541023 chr7:19748670 TWISTNB -0.45 -8.18 -0.31 1.5e-15 Night sleep phenotypes; BRCA cis rs3806843 0.966 rs2563255 chr5:140142547 T/C cg11822812 chr5:140052017 DND1 -0.31 -8.4 -0.32 2.86e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg02297831 chr4:17616191 MED28 0.36 8.49 0.32 1.41e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1975991 0.538 rs1479936 chr3:187967064 A/C cg15417654 chr3:187959138 LPP 0.33 8.41 0.32 2.6e-16 White matter integrity (bipolar disorder risk interaction); BRCA cis rs295137 0.836 rs10804097 chr2:201104924 A/T cg23649088 chr2:200775458 C2orf69 0.39 8.36 0.31 3.91e-16 Asthma (bronchodilator response); BRCA cis rs9296092 0.517 rs78978280 chr6:33520747 T/A cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg08917208 chr2:24149416 ATAD2B 0.9 12.95 0.46 3.2e-34 Lymphocyte counts; BRCA cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.7 0.39 1.11e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs11792861 0.591 rs10979613 chr9:111687584 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 13.07 0.46 8.73e-35 Menarche (age at onset); BRCA cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg01849466 chr14:104193079 ZFYVE21 0.44 11.3 0.41 4.14e-27 Schizophrenia; BRCA cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2303759 0.709 rs7256363 chr19:49827804 C/T cg22307029 chr19:49891270 CCDC155 0.53 8.83 0.33 1.04e-17 Multiple sclerosis; BRCA cis rs921968 0.510 rs2577761 chr2:219462500 G/A cg02176678 chr2:219576539 TTLL4 0.46 12.15 0.43 1.04e-30 Mean corpuscular hemoglobin concentration; BRCA trans rs9393777 0.920 rs34953377 chr6:27381660 T/C cg06606381 chr12:133084897 FBRSL1 -0.68 -7.85 -0.3 1.73e-14 Intelligence (multi-trait analysis); BRCA cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg02503808 chr4:7069936 GRPEL1 0.82 17.61 0.57 7.2e-57 Monocyte percentage of white cells; BRCA cis rs11690935 0.632 rs12991740 chr2:172885996 C/T cg13550731 chr2:172543902 DYNC1I2 0.53 13.16 0.46 3.58e-35 Schizophrenia; BRCA cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg23649088 chr2:200775458 C2orf69 -0.57 -8.54 -0.32 9.92e-17 Schizophrenia; BRCA trans rs7786808 0.741 rs11767875 chr7:158228923 A/G cg02030672 chr11:45687055 CHST1 0.39 8.28 0.31 7.49e-16 Obesity-related traits; BRCA cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg04248312 chr19:17393744 ANKLE1 -0.93 -21.69 -0.65 1.32e-78 Systemic lupus erythematosus; BRCA trans rs3733585 0.699 rs7663097 chr4:9966791 T/C cg26043149 chr18:55253948 FECH -0.38 -8.35 -0.31 4.17e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6484504 0.625 rs7112412 chr11:31370271 T/C cg06552810 chr11:31128660 NA 0.38 8.54 0.32 9.53e-17 Red blood cell count; BRCA trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs4566357 0.615 rs2272200 chr2:227912331 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.41 -0.35 8.84e-20 Coronary artery disease; BRCA trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg22491629 chr6:157744540 C6orf35 -0.67 -12.57 -0.45 1.58e-32 Hemostatic factors and hematological phenotypes; BRCA cis rs9650657 0.529 rs10108618 chr8:10953092 A/G cg21775007 chr8:11205619 TDH -0.48 -9.92 -0.37 1.16e-21 Neuroticism; BRCA cis rs72766638 0.895 rs55924785 chr9:136929586 C/T cg13789015 chr9:136890014 NCRNA00094 0.55 8.7 0.33 2.85e-17 Mosquito bite size; BRCA cis rs9297145 0.565 rs6952161 chr7:98733337 A/G cg05967295 chr7:98741636 SMURF1 0.64 13.86 0.48 2.1e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7809950 1.000 rs1544336 chr7:107082415 G/C cg23024343 chr7:107201750 COG5 -0.42 -9.69 -0.36 8.1899999999999992e-21 Coronary artery disease; BRCA cis rs2688608 0.592 rs11000757 chr10:75486815 T/C cg23231163 chr10:75533350 FUT11 -0.33 -8.7 -0.33 2.73e-17 Inflammatory bowel disease; BRCA cis rs9486719 1.000 rs2472889 chr6:96866803 T/G cg06623918 chr6:96969491 KIAA0776 0.74 12.99 0.46 2.1e-34 Migraine;Coronary artery disease; BRCA cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.19 -0.4 1.19e-26 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs1215050 0.791 rs6532702 chr4:98766641 C/T cg05340658 chr4:99064831 C4orf37 0.43 9.24 0.34 3.72e-19 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg22535103 chr8:58192502 C8orf71 -0.54 -9.18 -0.34 6.01e-19 Developmental language disorder (linguistic errors); BRCA cis rs1113500 0.933 rs12035689 chr1:108636756 T/C cg06207961 chr1:108661230 NA 0.45 11.07 0.4 3.47e-26 Growth-regulated protein alpha levels; BRCA cis rs78456975 1.000 rs78456975 chr2:1554190 T/G cg26248373 chr2:1572462 NA -0.5 -9.65 -0.36 1.16e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2625529 0.775 rs12913042 chr15:72202309 C/T cg16672083 chr15:72433130 SENP8 -0.82 -17.01 -0.56 8.39e-54 Red blood cell count; BRCA cis rs870825 0.616 rs28416641 chr4:185617999 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.28 0.56 3.69e-55 Blood protein levels; BRCA cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.82 0.3 2.19e-14 Total cholesterol levels; BRCA trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg06636001 chr8:8085503 FLJ10661 -0.5 -9.99 -0.37 6e-22 Neuroticism; BRCA cis rs6834538 1.000 rs7665050 chr4:113521476 G/C cg05166686 chr4:113558556 LARP7;C4orf21 0.38 8.36 0.31 3.88e-16 Free thyroxine concentration; BRCA cis rs10493773 0.775 rs12739713 chr1:86150378 C/T cg17807903 chr1:86174739 ZNHIT6 -0.46 -10.53 -0.38 4.88e-24 Urate levels in overweight individuals; BRCA cis rs7264396 0.635 rs2024854 chr20:34511189 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.9 -0.51 2.56e-43 Total cholesterol levels; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18758796 chr5:131593413 PDLIM4 0.33 8.69 0.33 3.09e-17 Breast cancer; BRCA trans rs9467711 0.790 rs13195402 chr6:26463575 G/T cg01620082 chr3:125678407 NA -0.83 -9.45 -0.35 6.18e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs4953076 0.573 rs6738023 chr2:44405931 T/C cg04920474 chr2:44395004 PPM1B 0.51 10.52 0.38 5.73e-24 Height; BRCA trans rs11098499 0.954 rs10008459 chr4:120394231 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.91 -0.3 1.15e-14 Corneal astigmatism; BRCA cis rs9290065 0.519 rs7635796 chr3:160674689 G/C cg03342759 chr3:160939853 NMD3 -0.46 -9.46 -0.35 5.88e-20 Kawasaki disease; BRCA cis rs9325144 0.560 rs13377717 chr12:38639474 T/A cg13010199 chr12:38710504 ALG10B -0.35 -8.38 -0.31 3.27e-16 Morning vs. evening chronotype; BRCA cis rs694739 0.796 rs479777 chr11:64107477 A/G cg23796481 chr11:64053134 BAD;GPR137 0.46 9.43 0.35 7.55e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs6424115 0.767 rs11591202 chr1:24102080 A/C cg15997130 chr1:24165203 NA -0.44 -10.21 -0.37 9.2e-23 Immature fraction of reticulocytes; BRCA cis rs6450176 0.859 rs3776719 chr5:53298684 T/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.52 -0.5 1.65e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2797160 1.000 rs2211419 chr6:125995533 C/T cg05901451 chr6:126070800 HEY2 0.38 9.25 0.34 3.23e-19 Endometrial cancer; BRCA cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg11366901 chr6:160182831 ACAT2 0.82 15.93 0.53 2.45e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg18230493 chr5:56204884 C5orf35 -0.72 -14.03 -0.49 3.47e-39 Initial pursuit acceleration; BRCA cis rs4808199 0.948 rs757001 chr19:19448808 G/A cg03709012 chr19:19516395 GATAD2A 1.0 18.63 0.59 3.29e-62 Nonalcoholic fatty liver disease; BRCA cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg01570182 chr17:44337453 NA 0.86 13.93 0.48 1.01e-38 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs11690935 0.959 rs1474074 chr2:172659852 G/A cg13550731 chr2:172543902 DYNC1I2 -0.89 -27.79 -0.74 4.85e-112 Schizophrenia; BRCA cis rs312274 0.630 rs10784898 chr12:41230722 A/G cg17827154 chr12:41323612 CNTN1 -0.42 -10.48 -0.38 7.99e-24 Metabolite levels (X-11787); BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg22907277 chr7:1156413 C7orf50 0.63 10.4 0.38 1.6e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9487051 0.768 rs399561 chr6:109524979 G/A cg21918786 chr6:109611834 NA -0.34 -9.1 -0.34 1.13e-18 Reticulocyte fraction of red cells; BRCA cis rs2153535 0.580 rs1932284 chr6:8477694 A/T cg07606381 chr6:8435919 SLC35B3 0.64 14.11 0.49 1.43e-39 Motion sickness; BRCA cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs11605924 0.901 rs7105751 chr11:45856973 G/A ch.11.939596F chr11:45881766 CRY2 -0.45 -9.68 -0.36 9.25e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg00149659 chr3:10157352 C3orf10 0.71 12.33 0.44 1.69e-31 Alzheimer's disease; BRCA cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg01028140 chr2:1542097 TPO -0.76 -15.19 -0.52 1.04e-44 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs523522 0.962 rs651627 chr12:121009198 C/T cg12219531 chr12:120966889 COQ5 0.55 11.64 0.42 1.56e-28 High light scatter reticulocyte count; BRCA cis rs3809566 1.000 rs4775610 chr15:63332057 C/T cg05507819 chr15:63340323 TPM1 -0.43 -9.34 -0.35 1.59e-19 Platelet count; BRCA cis rs1506636 1.000 rs614645 chr7:123442349 T/C cg03229431 chr7:123269106 ASB15 0.57 12.37 0.44 1.17e-31 Plateletcrit;Platelet count; BRCA cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg24088639 chr11:34937564 PDHX;APIP -0.43 -9.58 -0.35 2.08e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2204008 0.774 rs11520273 chr12:38354075 A/T cg13010199 chr12:38710504 ALG10B 0.45 9.38 0.35 1.16e-19 Bladder cancer; BRCA cis rs9394841 0.646 rs9471676 chr6:41815192 C/T cg08135965 chr6:41755394 TOMM6 0.5 8.27 0.31 7.76e-16 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs1506636 1.000 rs666266 chr7:123417759 A/G cg03229431 chr7:123269106 ASB15 0.61 13.54 0.47 6.54e-37 Plateletcrit;Platelet count; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg10150615 chr22:24372951 LOC391322 -0.42 -9.07 -0.34 1.44e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7586673 0.857 rs16845580 chr2:161920884 T/C cg21518248 chr2:162101506 NA 0.47 9.72 0.36 6.2e-21 Intelligence (multi-trait analysis); BRCA cis rs9420 0.961 rs11229148 chr11:57621460 A/T cg19752551 chr11:57585705 CTNND1 -0.51 -12.59 -0.45 1.21e-32 Schizophrenia; BRCA cis rs514406 0.505 rs269286 chr1:53169018 C/T cg24675658 chr1:53192096 ZYG11B 0.61 14.37 0.49 9.19e-41 Monocyte count; BRCA trans rs1459104 1.000 rs12793778 chr11:55085722 T/C cg03929089 chr4:120376271 NA 0.65 7.9 0.3 1.25e-14 Body mass index; BRCA cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -10.03 -0.37 4.42e-22 Body mass index; BRCA trans rs12310956 0.532 rs11052951 chr12:33986181 T/A cg26384229 chr12:38710491 ALG10B 0.47 10.43 0.38 1.26e-23 Morning vs. evening chronotype; BRCA cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg25801113 chr15:45476975 SHF 0.31 7.91 0.3 1.14e-14 Uric acid levels; BRCA cis rs10751667 0.666 rs7103585 chr11:971166 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs4699574 chr4:98725544 C/T cg05340658 chr4:99064831 C4orf37 0.63 15.15 0.51 1.51e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.652 rs250670 chr5:148446646 G/T cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.89e-31 Breast cancer; BRCA cis rs2806561 0.695 rs67238799 chr1:23335012 G/A cg19743168 chr1:23544995 NA 0.34 7.86 0.3 1.65e-14 Height; BRCA cis rs7903847 0.642 rs10882922 chr10:99158537 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.77 -0.33 1.56e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs3815700 1.000 rs10407204 chr19:33097353 C/T cg02997394 chr19:33096574 ANKRD27 0.69 11.65 0.42 1.45e-28 Eosinophilic esophagitis; BRCA cis rs9814567 0.929 rs2241556 chr3:134183312 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.36 8.05 0.3 4.19e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7572733 0.534 rs1607374 chr2:198800440 A/G cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.47e-21 Dermatomyositis; BRCA trans rs12310956 0.527 rs1608910 chr12:33895414 T/C cg13010199 chr12:38710504 ALG10B 0.37 8.1 0.31 2.77e-15 Morning vs. evening chronotype; BRCA cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg15605315 chr1:45957053 TESK2 -0.47 -9.26 -0.34 3.08e-19 High light scatter reticulocyte count; BRCA cis rs559928 0.597 rs2096706 chr11:63924446 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 11.33 0.41 2.98e-27 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs68170813 0.523 rs3757713 chr7:107042750 A/C cg02696742 chr7:106810147 HBP1 -0.52 -8.18 -0.31 1.58e-15 Coronary artery disease; BRCA trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg03929089 chr4:120376271 NA -0.52 -10.14 -0.37 1.68e-22 HDL cholesterol; BRCA cis rs12681288 0.862 rs2701898 chr8:1020812 C/T cg04851639 chr8:1020857 NA -0.36 -10.68 -0.39 1.29e-24 Schizophrenia; BRCA trans rs4332037 0.754 rs62436669 chr7:1926636 G/A cg25206134 chr2:45395956 NA 0.55 8.83 0.33 1.03e-17 Bipolar disorder; BRCA cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg06784218 chr1:46089804 CCDC17 -0.45 -10.84 -0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9435341 0.965 rs1335055 chr1:107624563 A/G cg09367891 chr1:107599246 PRMT6 0.42 8.29 0.31 6.87e-16 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs813218 0.565 rs2449106 chr3:99602087 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.41 8.7 0.33 2.85e-17 Orofacial clefts; BRCA cis rs4285028 0.747 rs7647351 chr3:121422109 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.97 -0.48 6.66e-39 Multiple sclerosis; BRCA trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg13010199 chr12:38710504 ALG10B 0.43 9.07 0.34 1.44e-18 Morning vs. evening chronotype; BRCA cis rs4478137 0.931 rs12509756 chr4:164237464 A/T cg06758707 chr4:164254230 NPY1R 0.59 12.99 0.46 2.04e-34 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg22974920 chr21:40686053 BRWD1 -0.35 -7.84 -0.3 1.91e-14 Menarche (age at onset); BRCA cis rs11971779 0.616 rs1133068 chr7:139053143 G/A cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs9560113 1.000 rs4773379 chr13:112176088 G/C cg10483660 chr13:112241077 NA 0.32 7.96 0.3 7.93e-15 Menarche (age at onset); BRCA cis rs4631830 0.720 rs7090326 chr10:51503375 A/T cg20129853 chr10:51489980 NA -0.3 -8.18 -0.31 1.59e-15 Prostate-specific antigen levels; BRCA cis rs503734 0.502 rs348861 chr3:100955259 G/A cg27318481 chr3:100970896 IMPG2 -0.4 -9.65 -0.36 1.17e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12291225 0.877 rs11023160 chr11:14264225 T/A cg19336497 chr11:14380999 RRAS2 -0.36 -8.04 -0.3 4.4e-15 Sense of smell; BRCA cis rs2070488 0.861 rs2067082 chr3:38438182 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 18.23 0.58 4.3e-60 Electrocardiographic conduction measures; BRCA cis rs36051895 0.658 rs7875265 chr9:5033882 C/A cg02405213 chr9:5042618 JAK2 -0.49 -9.21 -0.34 4.71e-19 Pediatric autoimmune diseases; BRCA trans rs7647973 0.626 rs1996663 chr3:49878264 C/G cg21659725 chr3:3221576 CRBN 0.45 8.1 0.31 2.83e-15 Menarche (age at onset); BRCA cis rs7818345 0.967 rs12678336 chr8:19280552 C/A cg11303988 chr8:19266685 CSGALNACT1 0.31 8.0 0.3 5.85e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg02659138 chr7:134003124 SLC35B4 0.34 10.65 0.39 1.64e-24 Mean platelet volume; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.61 9.66 0.36 1.02e-20 Renal function-related traits (BUN); BRCA cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg21573476 chr21:45109991 RRP1B -0.42 -11.31 -0.41 3.78e-27 Mean corpuscular volume; BRCA cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg24829409 chr8:58192753 C8orf71 -0.61 -12.73 -0.45 2.96e-33 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg04025307 chr7:1156635 C7orf50 0.6 15.1 0.51 2.65e-44 Longevity;Endometriosis; BRCA cis rs2386661 0.547 rs11259742 chr10:5647078 C/T cg17085576 chr10:5658249 NA -0.33 -8.19 -0.31 1.47e-15 Breast cancer; BRCA cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg21475434 chr5:93447410 FAM172A 0.66 8.69 0.33 2.92e-17 Diabetic retinopathy; BRCA cis rs6430585 0.528 rs309123 chr2:136761175 C/G cg07169764 chr2:136633963 MCM6 1.06 21.21 0.64 5.63e-76 Corneal structure; BRCA cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg07917127 chr4:99064746 C4orf37 0.44 8.15 0.31 1.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs614226 0.935 rs7956998 chr12:120994932 G/A cg01236616 chr12:121019343 POP5 1.25 27.71 0.74 1.32e-111 Type 1 diabetes nephropathy; BRCA cis rs6484504 0.625 rs672396 chr11:31386165 A/G cg06552810 chr11:31128660 NA 0.37 8.47 0.32 1.69e-16 Red blood cell count; BRCA cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg00101154 chr16:420108 MRPL28 -0.61 -15.09 -0.51 3.22e-44 Bone mineral density (spine);Bone mineral density; BRCA cis rs7631605 0.905 rs11711937 chr3:37224838 C/G cg15934958 chr3:37212084 LRRFIP2 -0.47 -10.84 -0.39 3.07e-25 Cerebrospinal P-tau181p levels; BRCA cis rs754466 0.580 rs10824576 chr10:79566040 G/C cg17075019 chr10:79541650 NA -0.75 -18.91 -0.6 1.08e-63 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7582720 1.000 rs72934554 chr2:203987806 C/G cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.77 0.45 2.02e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs9443189 0.570 rs7765254 chr6:76398143 T/C cg01950844 chr6:76311363 SENP6 0.77 10.48 0.38 7.68e-24 Prostate cancer; BRCA cis rs1348850 0.793 rs13027299 chr2:178455501 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.43 8.5 0.32 1.36e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs765787 0.530 rs3759892 chr15:45542709 A/G cg25801113 chr15:45476975 SHF -0.34 -8.28 -0.31 7.41e-16 Uric acid levels; BRCA cis rs7927771 0.524 rs11039431 chr11:47872012 G/T cg20307385 chr11:47447363 PSMC3 0.42 9.49 0.35 4.65e-20 Subjective well-being; BRCA cis rs7246657 1.000 rs8110011 chr19:37745813 G/T cg18154014 chr19:37997991 ZNF793 0.55 10.28 0.38 4.63e-23 Coronary artery calcification; BRCA cis rs9392556 0.829 rs7757606 chr6:4119704 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.37 -7.83 -0.3 2.05e-14 Blood metabolite levels; BRCA cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.75 15.37 0.52 1.35e-45 Smoking behavior; BRCA cis rs7580658 0.534 rs2089109 chr2:127951458 G/A cg16751203 chr2:127950803 CYP27C1 0.29 8.29 0.31 6.55e-16 Protein C levels; BRCA trans rs629535 0.814 rs652483 chr8:70055083 G/A cg21567404 chr3:27674614 NA 1.0 20.87 0.64 3.64e-74 Dupuytren's disease; BRCA cis rs7647973 0.925 rs4955439 chr3:49245645 G/T cg07636037 chr3:49044803 WDR6 -0.67 -13.44 -0.47 1.88e-36 Menarche (age at onset); BRCA cis rs6542838 0.704 rs56125264 chr2:99516699 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.39 -8.92 -0.33 5.07e-18 Fear of minor pain; BRCA cis rs10463316 0.894 rs7707964 chr5:150765475 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.42 -0.32 2.53e-16 Metabolite levels (Pyroglutamine); BRCA cis rs11098499 0.575 rs907204 chr4:120238654 G/A cg09307838 chr4:120376055 NA 0.64 13.91 0.48 1.32e-38 Corneal astigmatism; BRCA cis rs1511802 0.501 rs7684025 chr4:187116227 C/T cg24794857 chr4:187113578 CYP4V2 0.37 8.22 0.31 1.13e-15 Blood protein levels; BRCA cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg22535103 chr8:58192502 C8orf71 -0.48 -8.39 -0.32 3.09e-16 Developmental language disorder (linguistic errors); BRCA cis rs10751667 0.621 rs10794353 chr11:948740 A/G cg06064525 chr11:970664 AP2A2 -0.48 -16.27 -0.54 4.82e-50 Alzheimer's disease (late onset); BRCA cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.39 13.32 0.47 6.63e-36 Bipolar disorder; BRCA cis rs75229567 0.618 rs35394896 chr12:70188346 T/A cg10114359 chr12:70132523 RAB3IP 0.63 9.6 0.36 1.73e-20 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs7267979 1.000 rs2500432 chr20:25290512 A/C cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.02 0.3 5.15e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs807669 1.000 rs807670 chr22:19154608 A/C cg02655711 chr22:19163373 SLC25A1 0.55 13.15 0.46 4.02e-35 Metabolite levels; BRCA cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg26031613 chr14:104095156 KLC1 0.72 15.56 0.52 1.58e-46 Body mass index; BRCA cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg00677455 chr12:58241039 CTDSP2 -0.38 -8.53 -0.32 1.05e-16 Intelligence (multi-trait analysis); BRCA cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg08000102 chr2:233561755 GIGYF2 0.63 13.65 0.48 2.14e-37 Coronary artery disease; BRCA cis rs4308124 0.708 rs6716091 chr2:111991133 C/T cg04571233 chr2:111982156 NA -0.46 -9.85 -0.36 2.05e-21 Vitiligo; BRCA cis rs11030122 0.702 rs10500590 chr11:3964724 T/C cg18678763 chr11:4115507 RRM1 -0.36 -8.17 -0.31 1.6e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg27446573 chr6:127587934 RNF146 0.69 15.82 0.53 8.25e-48 Breast cancer; BRCA cis rs908922 0.676 rs4240884 chr1:152529792 C/T cg20991723 chr1:152506922 NA -0.37 -8.62 -0.32 5.15e-17 Hair morphology; BRCA cis rs1003719 0.523 rs1063949 chr21:38574675 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.61 -0.5 6.13e-42 Eye color traits; BRCA cis rs9914988 0.887 rs8078402 chr17:27145124 T/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.81 -0.33 1.13e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7617773 0.743 rs13071960 chr3:48367537 A/G cg11946769 chr3:48343235 NME6 0.67 13.61 0.47 3.13e-37 Coronary artery disease; BRCA cis rs11098499 1.000 rs13116504 chr4:120209412 A/C cg09307838 chr4:120376055 NA 0.63 12.83 0.45 1.07e-33 Corneal astigmatism; BRCA cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg15997130 chr1:24165203 NA -0.48 -13.15 -0.46 3.9e-35 Immature fraction of reticulocytes; BRCA cis rs1535500 0.905 rs2146262 chr6:39283793 C/T cg03252829 chr6:39282164 KCNK17 -0.3 -7.93 -0.3 9.47e-15 Type 2 diabetes; BRCA cis rs9435341 0.965 rs1762482 chr1:107599002 A/C cg09367891 chr1:107599246 PRMT6 -0.43 -8.52 -0.32 1.17e-16 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg08999081 chr20:33150536 PIGU -0.4 -10.3 -0.38 4.15e-23 Coronary artery disease; BRCA cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg06494592 chr3:125709126 NA -0.53 -8.87 -0.33 7.04e-18 Blood pressure (smoking interaction); BRCA cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 -0.6 -9.54 -0.35 3e-20 Lung function (FEV1/FVC); BRCA cis rs2075371 0.637 rs2544165 chr7:133920443 A/G cg11752832 chr7:134001865 SLC35B4 -0.44 -10.95 -0.4 1.09e-25 Mean platelet volume; BRCA cis rs7662987 0.517 rs3018048 chr4:100005538 C/T cg12011299 chr4:100065546 ADH4 0.48 10.95 0.4 1.07e-25 Smoking initiation; BRCA cis rs10751667 0.643 rs6597969 chr11:928843 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs3768617 0.565 rs4652775 chr1:183061825 A/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.11 0.54 2.97e-49 Fuchs's corneal dystrophy; BRCA cis rs473651 0.935 rs541013 chr2:239336492 G/A cg14266287 chr2:239334506 ASB1 -0.34 -8.27 -0.31 7.94e-16 Multiple system atrophy; BRCA cis rs9986765 0.737 rs10274253 chr7:142810265 G/C cg22531018 chr7:142981779 TMEM139 0.69 10.68 0.39 1.35e-24 Cancer;Dermatomyositis; BRCA cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.9e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg10523679 chr1:76189770 ACADM 0.68 12.61 0.45 1.03e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -16.18 -0.54 1.37e-49 Chronic sinus infection; BRCA cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg22800045 chr5:56110881 MAP3K1 0.65 12.31 0.44 2.11e-31 Initial pursuit acceleration; BRCA cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg24562669 chr7:97807699 LMTK2 0.46 12.16 0.43 9.2e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg11764359 chr7:65958608 NA 0.63 10.74 0.39 7.39e-25 Aortic root size; BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg02951883 chr7:2050386 MAD1L1 -0.36 -8.13 -0.31 2.17e-15 Bipolar disorder and schizophrenia; BRCA cis rs7561273 0.609 rs2339945 chr2:24348096 G/A cg04809136 chr2:24300158 SF3B14 -0.4 -8.94 -0.33 4.13e-18 Quantitative traits; BRCA cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg08219700 chr8:58056026 NA 0.45 8.31 0.31 5.78e-16 Developmental language disorder (linguistic errors); BRCA cis rs7786808 0.712 rs12671981 chr7:158202971 G/A cg01191920 chr7:158217561 PTPRN2 -0.34 -7.88 -0.3 1.4e-14 Obesity-related traits; BRCA cis rs6831352 0.918 rs29001211 chr4:100051941 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg17470723 chr8:74884337 TCEB1 0.4 8.6 0.32 6.02e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs559928 0.606 rs55942618 chr11:63936005 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.56 0.42 3.32e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg18876405 chr7:65276391 NA -0.51 -11.59 -0.42 2.49e-28 Aortic root size; BRCA cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg10802521 chr3:52805072 NEK4 -0.31 -8.05 -0.3 4.07e-15 Bipolar disorder; BRCA cis rs36051895 0.664 rs10117459 chr9:5094034 G/A cg02405213 chr9:5042618 JAK2 -0.5 -9.04 -0.34 1.81e-18 Pediatric autoimmune diseases; BRCA cis rs7011049 1.000 rs72640857 chr8:53839067 T/A cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs11585357 0.947 rs6666990 chr1:17611520 G/A cg08277548 chr1:17600880 PADI3 0.6 11.03 0.4 5.09e-26 Hair shape; BRCA cis rs559928 0.597 rs947939 chr11:63885287 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 11.05 0.4 4.08e-26 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA trans rs7618501 1.000 rs7634902 chr3:49762662 G/T cg21582582 chr3:182698605 DCUN1D1 -0.38 -10.12 -0.37 2.05e-22 Intelligence (multi-trait analysis); BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg18538332 chr22:24372958 LOC391322 0.5 11.75 0.42 5.26e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs875971 0.862 rs1695820 chr7:65844563 G/A cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs4285028 0.948 rs71329247 chr3:121681523 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.6 -10.64 -0.39 1.88e-24 Multiple sclerosis; BRCA cis rs709400 0.663 rs3783402 chr14:103967929 C/G cg24130564 chr14:104152367 KLC1 -0.35 -8.0 -0.3 5.8e-15 Body mass index; BRCA cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg03433033 chr1:76189801 ACADM 0.73 18.72 0.6 1.08e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.36 -8.02 -0.3 4.9e-15 Longevity;Endometriosis; BRCA cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.55 -0.32 9.35e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg02018176 chr4:1364513 KIAA1530 0.37 8.0 0.3 5.89e-15 Longevity; BRCA cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.35 -0.35 1.45e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg01939980 chr4:1354348 KIAA1530 0.33 8.99 0.33 2.88e-18 Longevity; BRCA cis rs2147904 1.000 rs2147904 chr1:42371414 C/T cg16685388 chr1:42384056 HIVEP3 -0.29 -8.24 -0.31 9.76e-16 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA trans rs7824557 0.767 rs2164273 chr8:11168499 A/G cg08975724 chr8:8085496 FLJ10661 0.41 7.99 0.3 6.26e-15 Retinal vascular caliber; BRCA cis rs796364 1.000 rs769949 chr2:200729558 A/G cg23649088 chr2:200775458 C2orf69 0.61 9.06 0.34 1.54e-18 Schizophrenia; BRCA cis rs7914558 1.000 rs10883824 chr10:104812897 A/G cg04362960 chr10:104952993 NT5C2 0.42 10.08 0.37 2.95e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2806561 0.704 rs663942 chr1:23522476 G/A cg12483005 chr1:23474871 LUZP1 0.47 10.43 0.38 1.23e-23 Height; BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg13628971 chr7:2884303 GNA12 0.48 9.63 0.36 1.44e-20 Height; BRCA cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg01483505 chr11:975446 AP2A2 0.34 9.11 0.34 1.02e-18 Alzheimer's disease (late onset); BRCA cis rs2204008 0.583 rs12307593 chr12:38317803 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.76 0.36 4.65e-21 Bladder cancer; BRCA cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg00321850 chr1:175162397 KIAA0040 0.41 11.37 0.41 2.11e-27 Alcohol dependence; BRCA cis rs1153858 1.000 rs1365610 chr15:45694610 C/T cg21132104 chr15:45694354 SPATA5L1 0.74 16.31 0.54 2.79e-50 Homoarginine levels; BRCA cis rs68170813 0.559 rs7783181 chr7:106977613 A/G cg02696742 chr7:106810147 HBP1 -0.49 -8.56 -0.32 8.5e-17 Coronary artery disease; BRCA trans rs7181230 0.813 rs4924417 chr15:40366939 G/C cg22705835 chr10:65332833 REEP3 -0.43 -9.55 -0.35 2.61e-20 Dehydroepiandrosterone sulphate levels; BRCA cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg09359103 chr1:154839909 KCNN3 -0.58 -15.09 -0.51 3.04e-44 Prostate cancer; BRCA cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -20.03 -0.62 1.28e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs478304 0.934 rs537786 chr11:65494987 C/T cg08755490 chr11:65554678 OVOL1 0.48 9.91 0.37 1.21e-21 Acne (severe); BRCA cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg09455208 chr3:40491958 NA -0.48 -11.97 -0.43 6.18e-30 Renal cell carcinoma; BRCA cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.09 -0.3 3.04e-15 Menarche (age at onset); BRCA cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg26384229 chr12:38710491 ALG10B -0.55 -13.58 -0.47 4.27e-37 Morning vs. evening chronotype; BRCA cis rs11984145 1.000 rs73121386 chr7:38865235 C/T cg19327137 chr7:38886074 VPS41 0.5 7.91 0.3 1.15e-14 Cognitive performance; BRCA cis rs7246657 0.551 rs12972146 chr19:37626095 G/T cg23950597 chr19:37808831 NA -0.65 -9.75 -0.36 5.12e-21 Coronary artery calcification; BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.85e-20 Tonsillectomy; BRCA cis rs9811920 0.809 rs793476 chr3:99541747 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -12.56 -0.44 1.72e-32 Axial length; BRCA cis rs911186 0.679 rs67330695 chr6:27103654 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -8.4 -0.32 2.98e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs765787 0.530 rs11854690 chr15:45516016 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA cis rs8030485 0.536 rs4778918 chr15:79434040 T/C cg17916960 chr15:79447300 NA 0.38 9.24 0.34 3.68e-19 Left ventricle wall thickness; BRCA cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.06 -0.3 3.69e-15 Bipolar disorder; BRCA cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.94 -0.62 3.92e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg10556349 chr10:835070 NA 0.61 8.48 0.32 1.59e-16 Eosinophil percentage of granulocytes; BRCA cis rs61931739 0.500 rs7979482 chr12:34542877 C/A cg06521331 chr12:34319734 NA -0.55 -9.93 -0.37 1.04e-21 Morning vs. evening chronotype; BRCA cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg19729930 chr2:74357872 NA 0.65 14.23 0.49 4e-40 Gestational age at birth (maternal effect); BRCA cis rs2180341 0.961 rs9375501 chr6:127652539 C/T cg24812749 chr6:127587940 RNF146 0.88 20.56 0.63 1.81e-72 Breast cancer; BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg13047869 chr3:10149882 C3orf24 0.53 10.94 0.4 1.14e-25 Alzheimer's disease; BRCA cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg02773041 chr1:40204384 PPIE 0.45 9.65 0.36 1.15e-20 Blood protein levels; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg01516881 chr6:292596 DUSP22 0.62 12.19 0.43 7.31e-31 Menopause (age at onset); BRCA cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -8.99 -0.34 2.73e-18 Alzheimer's disease (late onset); BRCA cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg03354898 chr7:1950403 MAD1L1 -0.42 -9.08 -0.34 1.39e-18 Schizophrenia; BRCA cis rs12612619 0.658 rs77920959 chr2:27151590 T/C cg00617064 chr2:27272375 NA -0.3 -7.95 -0.3 8.67e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs1832871 1.000 rs827864 chr6:158711023 A/G cg07215822 chr6:158701037 NA -0.43 -7.83 -0.3 1.97e-14 Height; BRCA cis rs73416724 1.000 rs73416724 chr6:43337802 A/G cg26312998 chr6:43337775 ZNF318 0.51 8.34 0.31 4.41e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1045529 0.524 rs34251783 chr8:8891376 T/C cg15556689 chr8:8085844 FLJ10661 -0.31 -8.15 -0.31 1.87e-15 Myopia;Myopia (pathological); BRCA cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.64 0.42 1.54e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9311474 0.935 rs7622851 chr3:52333671 C/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.36 -8.01 -0.3 5.56e-15 Electroencephalogram traits; BRCA trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.11 0.34 1.08e-18 Resting heart rate; BRCA cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.17 0.46 3.21e-35 Mean platelet volume; BRCA cis rs2243480 0.522 rs1638736 chr7:66092308 A/T cg18252515 chr7:66147081 NA -0.98 -11.53 -0.42 4.32e-28 Diabetic kidney disease; BRCA cis rs9858542 0.953 rs9827708 chr3:49649989 C/G cg03060546 chr3:49711283 APEH -0.57 -11.73 -0.42 6.53e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7301826 1.000 rs1106369 chr12:131300095 G/T cg11011512 chr12:131303247 STX2 0.41 10.55 0.39 4.12e-24 Plasma plasminogen activator levels; BRCA cis rs6815814 0.950 rs114719937 chr4:38808585 G/C cg06935464 chr4:38784597 TLR10 0.5 8.27 0.31 7.76e-16 Breast cancer; BRCA cis rs9660992 0.762 rs1172130 chr1:205244953 G/A cg00857998 chr1:205179979 DSTYK 0.4 7.91 0.3 1.13e-14 Mean corpuscular volume;Mean platelet volume; BRCA cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.17 0.31 1.65e-15 Tonsillectomy; BRCA cis rs7520050 0.966 rs12564541 chr1:46380237 G/A cg24296786 chr1:45957014 TESK2 0.44 9.98 0.37 7e-22 Red blood cell count;Reticulocyte count; BRCA cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg01483505 chr11:975446 AP2A2 0.33 9.07 0.34 1.44e-18 Alzheimer's disease (late onset); BRCA cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg10295955 chr4:187884368 NA -0.96 -28.43 -0.75 1.47e-115 Lobe attachment (rater-scored or self-reported); BRCA cis rs12950390 0.814 rs4794099 chr17:45838358 T/C cg03474202 chr17:45855739 NA -0.47 -12.57 -0.45 1.56e-32 IgG glycosylation; BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg11814155 chr7:99998594 ZCWPW1 0.45 8.35 0.31 4.16e-16 Platelet count; BRCA cis rs7539409 0.915 rs1977119 chr1:84275509 A/G cg10977910 chr1:84465055 TTLL7 0.69 9.77 0.36 4.04e-21 Alzheimer's disease; BRCA cis rs7264396 0.635 rs6119672 chr20:34479767 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.7 -14.62 -0.5 5.47e-42 Total cholesterol levels; BRCA cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4268898 0.686 rs2042468 chr2:24398446 A/T cg06627628 chr2:24431161 ITSN2 0.43 8.79 0.33 1.42e-17 Asthma; BRCA cis rs1538970 0.924 rs4660858 chr1:45936351 G/A cg05343316 chr1:45956843 TESK2 0.65 13.27 0.46 1.15e-35 Platelet count; BRCA cis rs3806843 0.966 rs3806844 chr5:140206263 A/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.87 -0.36 1.72e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs2505998 0.957 rs2435366 chr10:43571988 T/C cg15436174 chr10:43711423 RASGEF1A -0.44 -8.57 -0.32 7.49e-17 Hirschsprung disease; BRCA cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg18351406 chr4:77819688 ANKRD56 0.62 14.02 0.48 4.08e-39 Emphysema distribution in smoking; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg21724239 chr8:58056113 NA 0.58 9.4 0.35 9.72e-20 Developmental language disorder (linguistic errors); BRCA cis rs6973256 0.897 rs10808271 chr7:133352318 C/T cg07491979 chr7:133331646 EXOC4 0.4 9.28 0.34 2.59e-19 Intelligence (multi-trait analysis); BRCA trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg15704280 chr7:45808275 SEPT13 0.51 8.64 0.32 4.64e-17 Axial length; BRCA cis rs9325144 0.600 rs34138871 chr12:38735261 A/G cg26384229 chr12:38710491 ALG10B 0.47 12.21 0.43 5.95e-31 Morning vs. evening chronotype; BRCA cis rs7727544 0.618 rs2631367 chr5:131705458 C/G cg14196790 chr5:131705035 SLC22A5 -0.5 -13.59 -0.47 3.95e-37 Blood metabolite levels; BRCA cis rs12477438 0.520 rs11695379 chr2:99742161 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.6 0.39 2.69e-24 Chronic sinus infection; BRCA trans rs6479891 1.000 rs11817689 chr10:64924217 C/T cg14819942 chr15:35414228 NA -0.33 -8.24 -0.31 9.68e-16 Arthritis (juvenile idiopathic); BRCA trans rs4650994 0.525 rs4316329 chr1:178509333 C/T cg05059571 chr16:84539110 KIAA1609 -0.5 -11.12 -0.4 2.29e-26 HDL cholesterol levels;HDL cholesterol; BRCA cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg21285383 chr16:89894308 SPIRE2 -0.26 -8.9 -0.33 5.56e-18 Vitiligo; BRCA cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg25019033 chr10:957182 NA -0.41 -7.89 -0.3 1.3e-14 Eosinophil percentage of granulocytes; BRCA cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg22974920 chr21:40686053 BRWD1 -0.35 -7.93 -0.3 1.01e-14 Menarche (age at onset); BRCA cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg26874164 chr19:58962979 ZNF324B 0.52 11.31 0.41 3.52e-27 Uric acid clearance; BRCA cis rs7520050 0.966 rs4076006 chr1:46438076 C/T cg24296786 chr1:45957014 TESK2 0.44 9.76 0.36 4.56e-21 Red blood cell count;Reticulocyte count; BRCA trans rs9944715 0.954 rs9960378 chr18:43811262 G/A cg01718231 chr17:29326311 RNF135 -0.46 -9.07 -0.34 1.51e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.54 11.12 0.4 2.29e-26 Monocyte percentage of white cells; BRCA cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.16 0.31 1.77e-15 Axial length; BRCA cis rs9308433 0.529 rs17022608 chr1:214500907 A/C cg06198575 chr1:214491504 SMYD2 0.54 11.87 0.43 1.65e-29 IgG glycosylation; BRCA cis rs9309473 1.000 rs7607014 chr2:73730174 C/T cg20560298 chr2:73613845 ALMS1 0.45 11.27 0.41 5.54e-27 Metabolite levels; BRCA cis rs6547741 0.967 rs4665995 chr2:27813827 T/G cg27432699 chr2:27873401 GPN1 0.46 9.71 0.36 6.83e-21 Oral cavity cancer; BRCA cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg06636001 chr8:8085503 FLJ10661 0.53 11.96 0.43 7.09e-30 Mood instability; BRCA cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg10546459 chr2:36825355 FEZ2 0.46 8.79 0.33 1.38e-17 Height; BRCA cis rs7246657 0.943 rs10417503 chr19:37842735 T/C cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg06598544 chr20:61472147 COL9A3 0.74 10.8 0.39 4.44e-25 Obesity-related traits; BRCA cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg11742103 chr11:62369870 EML3;MTA2 0.53 13.44 0.47 2e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1008375 0.966 rs4698619 chr4:17580955 G/A cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6546886 0.912 rs6745236 chr2:74283728 C/T cg14702570 chr2:74259524 NA -0.32 -7.95 -0.3 8.42e-15 Dialysis-related mortality; BRCA cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA trans rs2018683 0.700 rs13227954 chr7:29017188 A/C cg19402173 chr7:128379420 CALU 0.44 10.19 0.37 1.05e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA trans rs7647973 0.667 rs6446286 chr3:49681704 A/G cg21659725 chr3:3221576 CRBN -0.47 -8.44 -0.32 2.17e-16 Menarche (age at onset); BRCA cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg18225595 chr11:63971243 STIP1 0.54 9.71 0.36 7.05e-21 Mean platelet volume; BRCA trans rs11098499 0.954 rs7687843 chr4:120421211 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.63e-30 Corneal astigmatism; BRCA cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg16339924 chr4:17578868 LAP3 -0.55 -13.01 -0.46 1.76e-34 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6484504 0.576 rs158146 chr11:31210433 G/A cg06552810 chr11:31128660 NA -0.37 -8.47 -0.32 1.65e-16 Red blood cell count; BRCA cis rs9986765 0.737 rs10274253 chr7:142810265 G/C cg15652212 chr7:142981776 TMEM139 0.67 10.29 0.38 4.31e-23 Cancer;Dermatomyositis; BRCA cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg00631329 chr6:26305371 NA -0.41 -12.17 -0.43 8.69e-31 Educational attainment; BRCA cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg18301423 chr5:131593218 PDLIM4 0.33 8.02 0.3 5.23e-15 Acylcarnitine levels; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg18402987 chr7:1209562 NA 0.87 12.28 0.44 2.89e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs977987 0.771 rs4888387 chr16:75389755 T/G cg03315344 chr16:75512273 CHST6 0.5 11.7 0.42 8.9e-29 Dupuytren's disease; BRCA cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.42 10.25 0.38 6.28e-23 Bone mineral density (spine);Bone mineral density; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg21143896 chr7:2802374 GNA12 -0.34 -8.49 -0.32 1.42e-16 Height; BRCA cis rs17270561 0.609 rs9358887 chr6:25759406 G/T cg17691542 chr6:26056736 HIST1H1C 0.5 9.69 0.36 7.96e-21 Iron status biomarkers; BRCA trans rs2204008 0.775 rs12099736 chr12:38344111 C/G cg06521331 chr12:34319734 NA -0.47 -8.56 -0.32 8.19e-17 Bladder cancer; BRCA cis rs17102884 0.506 rs4899540 chr14:75403408 G/A cg08847533 chr14:75593920 NEK9 -0.46 -9.37 -0.35 1.26e-19 Neuroticism; BRCA cis rs6570726 0.791 rs414600 chr6:145879606 G/A cg23711669 chr6:146136114 FBXO30 0.8 19.0 0.6 3.7e-64 Lobe attachment (rater-scored or self-reported); BRCA trans rs9650657 0.737 rs4841436 chr8:10594474 A/C cg06636001 chr8:8085503 FLJ10661 0.39 7.98 0.3 6.91e-15 Neuroticism; BRCA cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12379764 chr21:47803548 PCNT 0.49 9.66 0.36 1.1e-20 Testicular germ cell tumor; BRCA cis rs7659604 0.539 rs1507995 chr4:122748308 G/A cg20573242 chr4:122745356 CCNA2 0.48 10.84 0.39 2.88e-25 Type 2 diabetes; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 8.45 0.32 1.89e-16 Platelet count; BRCA cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.45 -10.12 -0.37 1.93e-22 Calcium levels; BRCA cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg20476274 chr7:133979776 SLC35B4 -0.59 -15.93 -0.53 2.44e-48 Mean platelet volume; BRCA cis rs71636778 0.543 rs71636796 chr1:27243095 T/C cg12203394 chr1:27248618 NUDC 0.6 9.46 0.35 5.7e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs7246657 0.722 rs2287229 chr19:38188652 G/A cg23950597 chr19:37808831 NA 0.51 8.69 0.33 2.96e-17 Coronary artery calcification; BRCA cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.28e-16 Colorectal cancer; BRCA cis rs9814567 0.806 rs2888670 chr3:134326684 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.26 -0.31 8.65e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6121246 0.559 rs6060950 chr20:30378031 T/C cg13852791 chr20:30311386 BCL2L1 0.96 23.26 0.68 3.39e-87 Mean corpuscular hemoglobin; BRCA cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg26384229 chr12:38710491 ALG10B 0.76 17.01 0.56 8.73e-54 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs9968172 chr3:134231251 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.75e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs6951245 0.832 rs10266519 chr7:1142977 C/T cg13565492 chr6:43139072 SRF -0.87 -13.16 -0.46 3.44e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.83 0.6 3.08e-63 Tonsillectomy; BRCA cis rs897984 0.542 rs11864806 chr16:31095204 G/C cg00531865 chr16:30841666 NA -0.38 -9.02 -0.34 2.25e-18 Dementia with Lewy bodies; BRCA trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg17830980 chr10:43048298 ZNF37B -0.56 -13.31 -0.47 7.11e-36 Extrinsic epigenetic age acceleration; BRCA cis rs514406 0.698 rs567880 chr1:53348564 T/G cg01802117 chr1:53393560 SCP2 -0.42 -9.61 -0.36 1.67e-20 Monocyte count; BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg05863683 chr7:1912471 MAD1L1 0.38 8.43 0.32 2.34e-16 Schizophrenia; BRCA cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.29 -0.34 2.4e-19 Menopause (age at onset); BRCA cis rs8114671 0.901 rs6119581 chr20:33773689 T/A cg07148914 chr20:33460835 GGT7 0.37 7.92 0.3 1.08e-14 Height; BRCA cis rs870825 0.616 rs6552801 chr4:185620623 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs4853036 1.000 rs11902295 chr2:70084599 C/T cg02498382 chr2:70120550 SNRNP27 -0.49 -9.02 -0.34 2.26e-18 Colorectal or endometrial cancer; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg23978390 chr7:1156363 C7orf50 0.49 11.31 0.41 3.7e-27 Longevity;Endometriosis; BRCA trans rs61931739 0.963 rs12307606 chr12:34016365 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.44 -0.35 6.98e-20 Morning vs. evening chronotype; BRCA cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg13271783 chr10:134563150 INPP5A -0.51 -9.62 -0.36 1.55e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.5 -0.44 2.98e-32 Bipolar disorder; BRCA cis rs511515 1 rs511515 chr6:33541507 A/G cg07679836 chr6:33548423 BAK1 0.64 13.96 0.48 7.64e-39 Eosinophil counts;Sum eosinophil basophil counts;Eosinophil percentage of white cells; BRCA cis rs2425143 0.908 rs74784474 chr20:34422464 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.97 -0.33 3.14e-18 Blood protein levels; BRCA cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.94 0.33 4.16e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg17892150 chr10:133769511 PPP2R2D -0.7 -14.38 -0.49 7.87e-41 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg19318889 chr4:1322082 MAEA 0.56 11.52 0.41 4.74e-28 Longevity; BRCA cis rs8180040 0.620 rs9844122 chr3:47108330 C/T cg16586182 chr3:47516702 SCAP -0.56 -12.63 -0.45 8.74e-33 Colorectal cancer; BRCA cis rs7091068 0.721 rs618951 chr10:95404967 A/G cg20715218 chr10:95462985 C10orf4 -0.46 -8.31 -0.31 5.67e-16 Urinary tract infection frequency; BRCA trans rs11098499 0.863 rs3736115 chr4:120488703 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.35 -8.09 -0.3 2.99e-15 Corneal astigmatism; BRCA cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg09060608 chr5:178986726 RUFY1 0.41 8.88 0.33 6.74e-18 Lung cancer; BRCA cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg08000102 chr2:233561755 GIGYF2 0.62 13.57 0.47 4.76e-37 Coronary artery disease; BRCA cis rs2580764 0.565 rs6545466 chr2:55228392 C/T cg09592903 chr2:55203963 RTN4 -0.41 -10.39 -0.38 1.86e-23 Mean platelet volume; BRCA cis rs782590 0.967 rs1823893 chr2:55788921 T/C cg18811423 chr2:55921094 PNPT1 0.71 22.68 0.67 5.59e-84 Metabolic syndrome; BRCA trans rs6089829 0.692 rs6122349 chr20:61664096 T/C cg23505145 chr19:12996616 KLF1 0.41 7.93 0.3 9.72e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.3 0.38 3.99e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9875589 0.509 rs1873005 chr3:14060223 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.97 0.33 3.39e-18 Ovarian reserve; BRCA cis rs10876993 0.784 rs1871417 chr12:58018979 C/T cg18357645 chr12:58087776 OS9 -0.41 -11.29 -0.41 4.25e-27 Celiac disease or Rheumatoid arthritis; BRCA cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2066819 1.000 rs79750959 chr12:56702012 C/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.14e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs1568889 1.000 rs61236373 chr11:28212720 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.74 0.5 1.61e-42 Bipolar disorder; BRCA cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg06552810 chr11:31128660 NA -0.39 -8.71 -0.33 2.51e-17 Red blood cell count; BRCA cis rs7267979 1.000 rs2259926 chr20:25281733 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.1e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2404602 0.647 rs12440965 chr15:76958591 G/A cg23625390 chr15:77176239 SCAPER -0.55 -12.99 -0.46 2.15e-34 Blood metabolite levels; BRCA cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA trans rs7615952 0.599 rs2270986 chr3:125701099 T/C cg07211511 chr3:129823064 LOC729375 -0.61 -10.74 -0.39 7.24e-25 Blood pressure (smoking interaction); BRCA cis rs34172651 0.917 rs8049667 chr16:24773524 G/A cg00339695 chr16:24857497 SLC5A11 0.34 7.99 0.3 6.38e-15 Intelligence (multi-trait analysis); BRCA cis rs2576037 0.901 rs2576036 chr18:44587102 G/T cg19077165 chr18:44547161 KATNAL2 -0.41 -8.9 -0.33 5.77e-18 Personality dimensions; BRCA cis rs4900538 0.892 rs4906208 chr14:102956489 G/C cg18135206 chr14:102964638 TECPR2 1.05 29.71 0.76 1.64e-122 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs17253792 0.822 rs75897560 chr14:56090965 C/T cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs6809651 0.524 rs10937240 chr3:185802823 C/T cg00760338 chr3:185826511 ETV5 -0.49 -9.74 -0.36 5.17e-21 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs3784262 0.631 rs12903724 chr15:58310387 G/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.19 -0.37 1.11e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs801193 0.569 rs881285 chr7:66119420 A/G cg11764359 chr7:65958608 NA -0.73 -16.04 -0.54 6.46e-49 Aortic root size; BRCA cis rs4237845 0.537 rs11172369 chr12:58280592 T/C cg02175503 chr12:58329896 NA 0.43 8.14 0.31 2e-15 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6545883 0.931 rs12713438 chr2:61725501 G/A cg15711740 chr2:61764176 XPO1 -0.52 -13.14 -0.46 4.42e-35 Tuberculosis; BRCA cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg03477792 chr4:77819574 ANKRD56 0.66 16.04 0.54 6.26e-49 Emphysema distribution in smoking; BRCA cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg21951975 chr1:209979733 IRF6 0.41 9.39 0.35 1.03e-19 Cleft lip with or without cleft palate; BRCA cis rs2014572 0.967 rs8112572 chr19:57759612 T/C cg24459738 chr19:57751996 ZNF805 -0.36 -8.54 -0.32 9.71e-17 Hyperactive-impulsive symptoms; BRCA cis rs5758659 0.652 rs133305 chr22:42395960 C/T cg15557168 chr22:42548783 NA -0.32 -8.81 -0.33 1.16e-17 Cognitive function; BRCA cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg20503657 chr10:835505 NA 1.03 18.17 0.58 9.16e-60 Eosinophil percentage of granulocytes; BRCA cis rs11711311 1.000 rs7633832 chr3:113472292 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.09 -0.37 2.66e-22 IgG glycosylation; BRCA cis rs738322 0.532 rs9622746 chr22:38564041 C/G cg25457927 chr22:38595422 NA -0.33 -11.15 -0.4 1.72e-26 Cutaneous nevi; BRCA cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg05340658 chr4:99064831 C4orf37 0.62 14.71 0.5 2.04e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.576 rs208072 chr11:31141288 A/G cg14844989 chr11:31128820 NA 0.42 8.87 0.33 7.3e-18 Red blood cell count; BRCA cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg25817165 chr18:72167213 CNDP2 -0.77 -19.53 -0.61 5.84e-67 Refractive error; BRCA cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.28 8.78 0.33 1.44e-17 Bipolar disorder; BRCA cis rs36051895 0.575 rs7035251 chr9:5133665 T/A cg02405213 chr9:5042618 JAK2 -0.46 -9.06 -0.34 1.58e-18 Pediatric autoimmune diseases; BRCA cis rs35146811 0.735 rs2272344 chr7:99786819 C/T cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.53 0.38 5.18e-24 Chronic sinus infection; BRCA cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg18230493 chr5:56204884 C5orf35 -0.73 -14.2 -0.49 5.69e-40 Initial pursuit acceleration; BRCA cis rs3857536 0.706 rs7749120 chr6:66889832 T/G cg07460842 chr6:66804631 NA -0.47 -9.09 -0.34 1.25e-18 Blood trace element (Cu levels); BRCA cis rs11711311 1.000 rs13073843 chr3:113449150 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs7412746 0.611 rs16827671 chr1:150738759 T/C cg15448220 chr1:150897856 SETDB1 0.36 8.12 0.31 2.45e-15 Melanoma; BRCA cis rs953387 1.000 rs2102896 chr2:136906640 T/C cg05194412 chr2:137003533 NA -0.37 -8.54 -0.32 1.01e-16 Arthritis (juvenile idiopathic); BRCA cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg24692254 chr21:30365293 RNF160 -0.46 -10.21 -0.37 9.05e-23 Dental caries; BRCA cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg08564027 chr20:61660810 NA 0.85 22.66 0.67 6.95e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg08807101 chr21:30365312 RNF160 0.44 9.54 0.35 2.94e-20 Pancreatic cancer; BRCA cis rs11098499 0.562 rs13101722 chr4:120555975 C/A cg09307838 chr4:120376055 NA -0.54 -11.25 -0.41 6.69e-27 Corneal astigmatism; BRCA cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg25214090 chr10:38739885 LOC399744 0.53 11.76 0.42 4.93e-29 Corneal astigmatism; BRCA cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.32 -0.41 3.19e-27 Uric acid levels; BRCA cis rs832540 0.519 rs6895442 chr5:56260998 T/C cg24531977 chr5:56204891 C5orf35 -0.43 -8.58 -0.32 7.45e-17 Coronary artery disease; BRCA cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg04450456 chr4:17643702 FAM184B 0.32 9.42 0.35 7.9e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg23505145 chr19:12996616 KLF1 0.54 12.07 0.43 2.28e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.65 11.47 0.41 8.15e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs826838 0.616 rs7966266 chr12:38626138 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.14 -0.37 1.63e-22 Heart rate; BRCA trans rs7819412 0.595 rs2409712 chr8:10986837 A/C cg15556689 chr8:8085844 FLJ10661 -0.37 -9.89 -0.36 1.48e-21 Triglycerides; BRCA cis rs332507 0.869 rs3772784 chr3:124394657 A/G cg05980111 chr3:124395277 KALRN 0.33 7.85 0.3 1.77e-14 Plateletcrit; BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg05863683 chr7:1912471 MAD1L1 0.37 8.22 0.31 1.14e-15 Bipolar disorder and schizophrenia; BRCA cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg03146154 chr1:46216737 IPP 0.45 10.06 0.37 3.5e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs798554 0.704 rs798503 chr7:2789704 G/A cg18446336 chr7:2847575 GNA12 -0.34 -8.01 -0.3 5.46e-15 Height; BRCA cis rs9649213 0.593 rs34534766 chr7:97920871 G/C cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.3e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2239547 0.657 rs2072391 chr3:52862200 C/T cg11645453 chr3:52864694 ITIH4 0.49 11.98 0.43 5.43e-30 Schizophrenia; BRCA cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg11833968 chr6:79620685 NA -0.43 -9.55 -0.35 2.69e-20 Intelligence (multi-trait analysis); BRCA cis rs2288073 0.965 rs10192600 chr2:24396680 A/G cg06627628 chr2:24431161 ITSN2 -0.64 -11.89 -0.43 1.43e-29 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.48e-61 Cognitive function; BRCA cis rs10751667 0.666 rs7395488 chr11:954111 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA trans rs7746199 0.736 rs13212093 chr6:27606716 C/T cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.76e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2197308 0.765 rs12370231 chr12:37917881 T/C cg26384229 chr12:38710491 ALG10B 0.76 16.93 0.56 2.12e-53 Morning vs. evening chronotype; BRCA cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg17724175 chr1:150552817 MCL1 -0.25 -8.55 -0.32 9.13e-17 Tonsillectomy; BRCA cis rs11105298 0.891 rs10858865 chr12:89846476 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.85 -0.36 2.02e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg18357645 chr12:58087776 OS9 0.42 11.98 0.43 5.87e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg14196790 chr5:131705035 SLC22A5 -0.41 -10.01 -0.37 5.1e-22 Breast cancer;Mosquito bite size; BRCA cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg10523679 chr1:76189770 ACADM -0.62 -11.45 -0.41 1.01e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs826838 0.616 rs4418873 chr12:38625473 C/A cg26384229 chr12:38710491 ALG10B 0.43 10.27 0.38 5.36e-23 Heart rate; BRCA cis rs9926296 0.585 rs6500450 chr16:89858024 A/G cg27121462 chr16:89883253 FANCA 0.69 16.33 0.54 2.32e-50 Vitiligo; BRCA cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg18876405 chr7:65276391 NA -0.49 -10.8 -0.39 4.34e-25 Aortic root size; BRCA cis rs7772486 0.790 rs7742333 chr6:146159029 A/G cg13319975 chr6:146136371 FBXO30 0.39 8.96 0.33 3.65e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg26314531 chr2:26401878 FAM59B -0.95 -16.42 -0.54 8.01e-51 Gut microbiome composition (summer); BRCA trans rs877282 0.898 rs2004478 chr10:770709 C/A cg22713356 chr15:30763199 NA 1.18 23.59 0.68 5.88e-89 Uric acid levels; BRCA cis rs12586317 0.620 rs8020370 chr14:35581432 G/A cg05294307 chr14:35346193 BAZ1A -0.58 -10.31 -0.38 3.83e-23 Psoriasis; BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg08888203 chr3:10149979 C3orf24 0.68 14.36 0.49 9.39e-41 Alzheimer's disease; BRCA cis rs2839186 0.732 rs55904887 chr21:47707811 A/G cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA trans rs11250098 0.547 rs2409764 chr8:11281273 C/T cg15556689 chr8:8085844 FLJ10661 0.37 9.5 0.35 4.25e-20 Morning vs. evening chronotype; BRCA cis rs11585357 0.947 rs2977304 chr1:17611615 T/C cg19159961 chr1:17633534 PADI4 -0.5 -8.91 -0.33 5.23e-18 Hair shape; BRCA cis rs3772130 0.540 rs7627354 chr3:121562434 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.39 0.49 7.2e-41 Cognitive performance; BRCA cis rs9527 0.590 rs7901197 chr10:104840433 C/T cg04362960 chr10:104952993 NT5C2 0.44 9.82 0.36 2.72e-21 Arsenic metabolism; BRCA cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg11789530 chr4:8429930 ACOX3 -0.59 -14.89 -0.51 2.89e-43 Response to antineoplastic agents; BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg03354898 chr7:1950403 MAD1L1 -0.44 -9.15 -0.34 7.75e-19 Schizophrenia; BRCA cis rs6866344 0.601 rs4419608 chr5:178097049 C/T cg10224037 chr5:178157518 ZNF354A 0.6 11.17 0.4 1.32e-26 Neutrophil percentage of white cells; BRCA trans rs61931739 0.534 rs10844728 chr12:34020109 G/C cg26384229 chr12:38710491 ALG10B 0.67 14.03 0.49 3.66e-39 Morning vs. evening chronotype; BRCA trans rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.88 0.3 1.44e-14 Endometrial cancer; BRCA cis rs11677370 0.603 rs10198219 chr2:3854600 T/C cg17052675 chr2:3827356 NA -0.47 -11.57 -0.42 3.17e-28 Type 2 diabetes; BRCA cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg02951883 chr7:2050386 MAD1L1 -0.4 -9.2 -0.34 5.06e-19 Schizophrenia; BRCA trans rs453301 0.571 rs330048 chr8:9087278 A/C cg11608241 chr8:8085544 FLJ10661 -0.27 -7.86 -0.3 1.66e-14 Joint mobility (Beighton score); BRCA cis rs12541635 1.000 rs1366965 chr8:107085224 T/A cg10147462 chr8:107024639 NA -0.3 -8.25 -0.31 9.29e-16 Age of smoking initiation; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2882667 0.898 rs3925110 chr5:138371365 C/G cg04439458 chr5:138467593 SIL1 -0.32 -8.66 -0.32 3.99e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13315871 1.000 rs36097398 chr3:58367330 G/A cg20936604 chr3:58311152 NA -0.62 -7.94 -0.3 9.28e-15 Cholesterol, total; BRCA cis rs4285028 0.948 rs12497349 chr3:121708517 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.94 -0.4 1.16e-25 Multiple sclerosis; BRCA cis rs736408 0.609 rs2336545 chr3:52787603 C/T cg18404041 chr3:52824283 ITIH1 0.43 12.79 0.45 1.6e-33 Bipolar disorder; BRCA cis rs6942756 0.955 rs68187585 chr7:129002211 T/C cg02491457 chr7:128862824 NA -0.72 -14.03 -0.49 3.56e-39 White matter hyperintensity burden; BRCA cis rs35146811 0.735 rs1138417 chr7:99807146 C/G cg13334819 chr7:99746414 C7orf59 0.38 8.8 0.33 1.27e-17 Coronary artery disease; BRCA cis rs7474896 0.537 rs1208683 chr10:38093723 A/G cg25427524 chr10:38739819 LOC399744 0.49 8.67 0.32 3.54e-17 Obesity (extreme); BRCA cis rs7737355 0.773 rs10040578 chr5:130950232 C/T cg06307176 chr5:131281290 NA -0.48 -10.01 -0.37 5.01e-22 Life satisfaction; BRCA cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg19010396 chr19:19431384 KIAA0892;SF4 -0.45 -9.05 -0.34 1.69e-18 Tonsillectomy; BRCA cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.04 0.3 4.43e-15 Menopause (age at onset); BRCA cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg18825119 chr6:163149453 PACRG;PARK2 -0.47 -8.28 -0.31 7.45e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2070488 0.695 rs6599201 chr3:38476614 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.23 0.56 6.21e-55 Electrocardiographic conduction measures; BRCA cis rs829883 0.664 rs865509 chr12:98854444 T/A cg25150519 chr12:98850993 NA 0.68 16.4 0.54 1.01e-50 Colorectal adenoma (advanced); BRCA cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg24562669 chr7:97807699 LMTK2 0.47 12.52 0.44 2.56e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs1865760 1.000 rs3799371 chr6:25912816 A/G cg17691542 chr6:26056736 HIST1H1C -0.51 -10.62 -0.39 2.35e-24 Height; BRCA cis rs7772486 0.840 rs11155451 chr6:146422524 A/G cg05347473 chr6:146136440 FBXO30 0.41 7.98 0.3 7.02e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs738322 0.718 rs3761445 chr22:38595411 G/A cg25457927 chr22:38595422 NA 0.51 21.86 0.65 1.55e-79 Cutaneous nevi; BRCA cis rs2070488 0.804 rs13059256 chr3:38504315 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.32 0.57 2.29e-55 Electrocardiographic conduction measures; BRCA cis rs59698941 0.527 rs1910075 chr5:132180089 A/T cg14825688 chr5:132208181 LEAP2 -0.37 -8.51 -0.32 1.19e-16 Apolipoprotein A-IV levels; BRCA cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg13319975 chr6:146136371 FBXO30 0.38 8.64 0.32 4.34e-17 Lobe attachment (rater-scored or self-reported); BRCA trans rs3942852 0.806 rs10838805 chr11:48118993 A/C cg15704280 chr7:45808275 SEPT13 -0.48 -9.08 -0.34 1.35e-18 Acute lymphoblastic leukemia (childhood); BRCA trans rs11098499 0.863 rs11098531 chr4:120465001 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs1468333 1.000 rs2864 chr5:137523430 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.44 8.64 0.32 4.6e-17 Resting heart rate; BRCA cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.28 -0.34 2.53e-19 Tonsillectomy; BRCA trans rs61931739 0.534 rs4539411 chr12:34014807 T/C cg26384229 chr12:38710491 ALG10B 0.53 11.39 0.41 1.68e-27 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs6546767 chr2:26328746 A/G cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs17711722 0.701 rs781143 chr7:65439879 G/C cg18876405 chr7:65276391 NA 0.71 18.63 0.59 3.45e-62 Calcium levels; BRCA cis rs9527 0.590 rs11191547 chr10:104843148 C/T cg04362960 chr10:104952993 NT5C2 0.45 10.27 0.38 5.19e-23 Arsenic metabolism; BRCA cis rs2637030 0.559 rs376566 chr5:53005420 G/A cg06476337 chr5:52856530 NDUFS4 0.35 7.99 0.3 6.1e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA trans rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05039488 chr6:79577232 IRAK1BP1 0.36 8.01 0.3 5.45e-15 Endometrial cancer; BRCA trans rs9329221 0.650 rs657913 chr8:9882575 G/T cg06636001 chr8:8085503 FLJ10661 -0.49 -10.18 -0.37 1.14e-22 Neuroticism; BRCA cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs7918232 0.941 rs1085782 chr10:27440517 G/A cg14240646 chr10:27532245 ACBD5 0.64 9.49 0.35 4.66e-20 Breast cancer; BRCA cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg25237894 chr2:233734115 C2orf82 0.39 11.24 0.41 7.05e-27 Coronary artery disease; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.59 -11.18 -0.4 1.27e-26 Gut microbiome composition (summer); BRCA trans rs61931739 1.000 rs12427391 chr12:34022891 A/G cg26384229 chr12:38710491 ALG10B -0.41 -9.32 -0.35 1.81e-19 Morning vs. evening chronotype; BRCA cis rs314370 1.000 rs10278546 chr7:100516003 G/T cg10426581 chr7:100472382 SRRT -0.52 -8.97 -0.33 3.39e-18 Resting heart rate; BRCA cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg17143192 chr8:8559678 CLDN23 0.52 10.05 0.37 3.82e-22 Obesity-related traits; BRCA cis rs1371614 0.610 rs12615509 chr2:27098766 G/A cg12368169 chr2:27073192 DPYSL5 -0.3 -8.98 -0.33 3.1e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA trans rs1973993 0.603 rs3912027 chr1:96993603 G/T cg10631902 chr5:14652156 NA -0.4 -10.04 -0.37 4.16e-22 Weight; BRCA cis rs7819412 0.521 rs4451268 chr8:11034859 A/G cg21775007 chr8:11205619 TDH -0.45 -9.13 -0.34 8.93e-19 Triglycerides; BRCA cis rs6901004 0.935 rs9487602 chr6:111560946 C/T cg15721981 chr6:111408429 SLC16A10 0.36 8.2 0.31 1.31e-15 Blood metabolite levels; BRCA cis rs11229555 0.645 rs7116847 chr11:58178478 C/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs6582630 0.519 rs11520262 chr12:38333051 A/G cg06521331 chr12:34319734 NA -0.48 -8.66 -0.32 3.93e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs35123781 0.696 rs356433 chr5:139071193 C/T cg10513866 chr5:139070639 NA 0.43 9.5 0.35 4.18e-20 Schizophrenia; BRCA trans rs208520 1.000 rs72884017 chr6:66992513 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.39 0.49 7.25e-41 Exhaled nitric oxide output; BRCA cis rs4908768 0.501 rs1473420 chr1:8616838 T/G cg20416874 chr1:8611966 RERE -0.29 -8.42 -0.32 2.57e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1580019 0.961 rs4255041 chr7:32496383 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.08 0.54 4.26e-49 Cognitive ability; BRCA trans rs3733585 0.637 rs6850684 chr4:9964380 G/T cg26043149 chr18:55253948 FECH -0.37 -8.21 -0.31 1.2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15506890 chr2:3487001 NA -0.58 -13.17 -0.46 3.14e-35 Neurofibrillary tangles; BRCA cis rs9503598 0.778 rs1328688 chr6:3468508 G/A cg00476032 chr6:3446245 SLC22A23 0.43 10.57 0.39 3.43e-24 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs8180040 0.966 rs2101247 chr3:47494303 G/A cg27129171 chr3:47204927 SETD2 -0.68 -15.83 -0.53 7.58e-48 Colorectal cancer; BRCA cis rs9467773 0.967 rs9461267 chr6:26525455 T/G cg11502198 chr6:26597334 ABT1 0.48 9.59 0.35 2.02e-20 Intelligence (multi-trait analysis); BRCA cis rs17711722 0.727 rs35850374 chr7:65357776 A/G cg18876405 chr7:65276391 NA 0.7 18.62 0.59 3.8e-62 Calcium levels; BRCA cis rs12682352 0.602 rs11783966 chr8:8665147 A/G cg08975724 chr8:8085496 FLJ10661 -0.39 -8.21 -0.31 1.18e-15 Neuroticism; BRCA cis rs6942756 0.713 rs692597 chr7:129132554 T/G cg02491457 chr7:128862824 NA -0.54 -11.28 -0.41 4.87e-27 White matter hyperintensity burden; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg23131131 chr22:24373011 LOC391322 0.39 8.84 0.33 9.61e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg11608241 chr8:8085544 FLJ10661 0.33 9.78 0.36 3.94e-21 Mood instability; BRCA cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg14728415 chr7:32535168 LSM5;AVL9 -0.39 -8.46 -0.32 1.82e-16 Cognitive ability; BRCA cis rs7267979 1.000 rs3761117 chr20:25388070 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.55 -0.32 9.15e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9914988 0.887 rs2070265 chr17:27075423 A/G cg20469991 chr17:27169893 C17orf63 0.44 8.78 0.33 1.44e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs3812831 0.669 rs7327370 chr13:114946858 A/G cg06611532 chr13:114900021 NA 0.38 10.15 0.37 1.57e-22 Schizophrenia; BRCA cis rs11718455 1.000 rs9858826 chr3:44031412 C/T cg08738300 chr3:44038990 NA -0.43 -8.63 -0.32 4.76e-17 Coronary artery disease; BRCA cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg04455712 chr21:45112962 RRP1B 0.4 9.53 0.35 3.18e-20 Mean corpuscular volume; BRCA cis rs6815814 0.861 rs10004195 chr4:38784724 T/A cg06935464 chr4:38784597 TLR10 0.46 8.91 0.33 5.15e-18 Breast cancer; BRCA trans rs7980799 0.935 rs10732554 chr12:33533374 C/T cg26384229 chr12:38710491 ALG10B -0.39 -8.27 -0.31 7.56e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs427394 0.582 rs274661 chr5:6704848 C/T cg10857441 chr5:6722123 POLS -0.3 -9.41 -0.35 9.02e-20 Menopause (age at onset); BRCA cis rs17253792 0.822 rs28513551 chr14:56094993 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg04455712 chr21:45112962 RRP1B -0.44 -12.0 -0.43 4.64e-30 Mean corpuscular volume; BRCA cis rs17401966 0.931 rs12753426 chr1:10372110 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.51 0.47 9.16e-37 Hepatocellular carcinoma; BRCA cis rs17685 0.712 rs10275521 chr7:75770972 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg11890956 chr21:40555474 PSMG1 -0.65 -14.71 -0.5 2.1e-42 Menarche (age at onset); BRCA cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg16482183 chr6:26056742 HIST1H1C 0.49 10.39 0.38 1.79e-23 Height; BRCA cis rs2832191 0.967 rs1999321 chr21:30530233 A/C cg08807101 chr21:30365312 RNF160 0.55 13.15 0.46 3.96e-35 Dental caries; BRCA cis rs11229555 0.874 rs17567523 chr11:58354081 G/A cg15696309 chr11:58395628 NA -0.53 -11.49 -0.41 6.88e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs12517041 1.000 rs2099091 chr5:23295532 T/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.92 -0.3 1.04e-14 Calcium levels; BRCA cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.64 14.63 0.5 4.96e-42 Age-related macular degeneration (geographic atrophy); BRCA cis rs17253792 0.822 rs9972180 chr14:56073732 G/T cg01858014 chr14:56050164 KTN1 -0.78 -10.82 -0.39 3.74e-25 Putamen volume; BRCA cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg13319975 chr6:146136371 FBXO30 0.35 8.22 0.31 1.12e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.75e-15 Developmental language disorder (linguistic errors); BRCA cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.71 0.42 7.82e-29 Height; BRCA cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg03264133 chr6:25882463 NA -0.57 -12.02 -0.43 3.65e-30 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg11644478 chr21:40555479 PSMG1 0.54 11.72 0.42 7.36e-29 Cognitive function; BRCA cis rs8017423 0.967 rs8009493 chr14:90690083 G/C cg04374321 chr14:90722782 PSMC1 0.72 18.59 0.59 5.19e-62 Mortality in heart failure; BRCA cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.42 8.98 0.33 3.04e-18 Bipolar disorder; BRCA cis rs868036 0.609 rs2278076 chr15:68099600 C/T cg05925327 chr15:68127851 NA -0.44 -9.5 -0.35 4.19e-20 Restless legs syndrome; BRCA cis rs4423214 0.879 rs1790324 chr11:71150520 A/C cg05163923 chr11:71159392 DHCR7 -0.58 -12.52 -0.44 2.62e-32 Vitamin D levels; BRCA cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg16405210 chr4:1374714 KIAA1530 -0.51 -12.08 -0.43 2.15e-30 Longevity; BRCA cis rs965469 0.779 rs6051761 chr20:3321568 A/G cg25506879 chr20:3388711 C20orf194 0.45 9.19 0.34 5.57e-19 IFN-related cytopenia; BRCA cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.54 -10.19 -0.37 1.11e-22 Aortic root size; BRCA cis rs2559856 1.000 rs2695292 chr12:102087290 G/A cg12924262 chr12:102091054 CHPT1 0.38 8.56 0.32 8.5e-17 Blood protein levels; BRCA cis rs812925 0.502 rs13028833 chr2:61644329 C/G cg15711740 chr2:61764176 XPO1 0.32 8.02 0.3 5.08e-15 Immature fraction of reticulocytes; BRCA cis rs7772486 0.875 rs6930975 chr6:146387111 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.66 0.5 3.75e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg13256891 chr4:100009986 ADH5 0.52 9.77 0.36 4.15e-21 Alcohol dependence; BRCA cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg06550200 chr5:1325588 CLPTM1L -0.62 -12.94 -0.46 3.35e-34 Lung cancer; BRCA trans rs3960554 0.808 rs112962015 chr7:75659303 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 12.23 0.44 4.52e-31 Eotaxin levels; BRCA cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg03425785 chr20:62221387 GMEB2 0.52 8.4 0.32 2.99e-16 Glioma;Non-glioblastoma glioma;Glioblastoma; BRCA cis rs7131987 0.903 rs6487796 chr12:29422764 A/G cg09582351 chr12:29534625 ERGIC2 -0.48 -11.65 -0.42 1.44e-28 QT interval; BRCA cis rs27434 0.660 rs42398 chr5:96120455 C/T cg16492584 chr5:96139282 ERAP1 -0.39 -7.87 -0.3 1.54e-14 Ankylosing spondylitis; BRCA cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.48 0.32 1.62e-16 Multiple sclerosis; BRCA cis rs17095355 1.000 rs55717725 chr10:111666629 T/C cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.58 -0.35 2.1e-20 Biliary atresia; BRCA cis rs796364 0.806 rs79333757 chr2:200915716 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs2624839 0.704 rs12637671 chr3:50224562 G/A cg14019146 chr3:50243930 SLC38A3 0.63 16.14 0.54 2.08e-49 Intelligence (multi-trait analysis); BRCA cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg18225595 chr11:63971243 STIP1 0.59 14.28 0.49 2.37e-40 Platelet count; BRCA cis rs7147624 1.000 rs4902408 chr14:66111901 A/T cg03016385 chr14:66212404 NA -0.55 -8.73 -0.33 2.15e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg25427524 chr10:38739819 LOC399744 -0.6 -13.69 -0.48 1.39e-37 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg08917208 chr2:24149416 ATAD2B 0.55 8.61 0.32 5.76e-17 Lymphocyte counts; BRCA cis rs703842 0.616 rs871871 chr12:58219681 G/A cg00677455 chr12:58241039 CTDSP2 0.76 18.1 0.58 2.01e-59 Multiple sclerosis; BRCA cis rs9325144 0.624 rs12231544 chr12:38901956 C/T cg26384229 chr12:38710491 ALG10B -0.51 -12.25 -0.44 4.02e-31 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg00814883 chr7:100076585 TSC22D4 -0.54 -11.75 -0.42 5.12e-29 Platelet count; BRCA cis rs561341 1.000 rs564714 chr17:30318404 C/T cg12193833 chr17:30244370 NA -0.58 -8.89 -0.33 6.38e-18 Hip circumference adjusted for BMI; BRCA cis rs1401999 0.714 rs7646621 chr3:183640865 A/C cg20387954 chr3:183756860 HTR3D -0.34 -7.97 -0.3 7.22e-15 Anterior chamber depth; BRCA cis rs7586673 0.930 rs6432667 chr2:161905001 T/C cg08807892 chr2:162101083 NA 0.45 8.84 0.33 9.19e-18 Intelligence (multi-trait analysis); BRCA cis rs11105298 0.891 rs10858851 chr12:89830870 C/T cg00757033 chr12:89920650 WDR51B 0.52 10.42 0.38 1.4e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.67 0.5 3.35e-42 Colorectal cancer; BRCA cis rs4919694 1.000 rs11191473 chr10:104710710 C/G cg04362960 chr10:104952993 NT5C2 0.97 15.09 0.51 3.25e-44 Arsenic metabolism; BRCA cis rs1580019 0.520 rs6945238 chr7:32646096 C/T cg06627557 chr7:32535165 LSM5;AVL9 -0.96 -20.31 -0.63 3.82e-71 Cognitive ability; BRCA cis rs367943 1.000 rs348946 chr5:112822814 C/T cg12552261 chr5:112820674 MCC -0.55 -12.01 -0.43 4.05e-30 Type 2 diabetes; BRCA cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg04414720 chr1:150670196 GOLPH3L 0.36 8.28 0.31 7.44e-16 Tonsillectomy; BRCA cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg01579765 chr21:45077557 HSF2BP -0.41 -10.81 -0.39 4.11e-25 Mean corpuscular volume; BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg22920501 chr2:26401640 FAM59B 0.71 11.93 0.43 8.95e-30 Gut microbiome composition (summer); BRCA cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg23649088 chr2:200775458 C2orf69 -0.56 -8.32 -0.31 5.18e-16 Schizophrenia; BRCA cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg12386194 chr3:101231763 SENP7 0.66 12.87 0.45 7.01e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.54 -12.07 -0.43 2.34e-30 Colorectal cancer; BRCA cis rs9790314 0.967 rs1382427 chr3:161032576 T/C cg04691961 chr3:161091175 C3orf57 -0.58 -13.95 -0.48 8.48e-39 Morning vs. evening chronotype; BRCA cis rs941873 0.772 rs7920127 chr10:81122914 T/C cg11057378 chr10:81107060 PPIF 0.4 9.5 0.35 4.24e-20 Height; BRCA cis rs11190604 1.000 rs2489049 chr10:102350732 G/A cg07080220 chr10:102295463 HIF1AN 0.52 12.02 0.43 3.88e-30 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2992756 0.663 rs2992762 chr1:18804609 A/G cg14356550 chr1:18808102 KLHDC7A -0.39 -8.1 -0.3 2.9e-15 Breast cancer; BRCA cis rs9467773 0.967 rs6932865 chr6:26540166 C/A cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.21 0.49 4.81e-40 Platelet count; BRCA trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21659725 chr3:3221576 CRBN -0.72 -22.05 -0.66 1.48e-80 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.931 rs10939734 chr4:17570709 C/T cg04450456 chr4:17643702 FAM184B 0.42 12.21 0.44 5.57e-31 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11098499 0.954 rs34858317 chr4:120387110 A/C cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs4862750 0.914 rs11945845 chr4:187874136 T/C cg03452623 chr4:187889614 NA -0.35 -11.59 -0.42 2.63e-28 Lobe attachment (rater-scored or self-reported); BRCA trans rs7613875 0.600 rs2856238 chr3:50158191 C/T cg21659725 chr3:3221576 CRBN 0.35 8.54 0.32 9.47e-17 Body mass index; BRCA cis rs6558530 0.692 rs7818406 chr8:1701250 C/T cg19131313 chr8:1704013 NA -0.4 -8.08 -0.3 3.29e-15 Systolic blood pressure; BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg22800045 chr5:56110881 MAP3K1 0.68 13.05 0.46 1.14e-34 Initial pursuit acceleration; BRCA cis rs2153535 0.580 rs9393019 chr6:8462091 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.38 0.38 2.03e-23 Motion sickness; BRCA cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4363385 0.747 rs1415970 chr1:152965741 G/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.38 -0.35 1.14e-19 Inflammatory skin disease; BRCA cis rs932287 0.505 rs2742536 chr11:8909816 G/C cg12365402 chr11:9010492 NRIP3 -0.39 -8.85 -0.33 8.54e-18 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.500 rs10844846 chr12:34394611 C/G cg26384229 chr12:38710491 ALG10B 0.58 13.26 0.46 1.25e-35 Morning vs. evening chronotype; BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg09177884 chr7:1199841 ZFAND2A -0.64 -16.56 -0.55 1.55e-51 Longevity;Endometriosis; BRCA cis rs561341 0.941 rs550213 chr17:30317518 C/G cg23018236 chr17:30244563 NA -0.46 -8.36 -0.31 3.92e-16 Hip circumference adjusted for BMI; BRCA cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg18876405 chr7:65276391 NA -0.62 -15.3 -0.52 2.87e-45 Aortic root size; BRCA cis rs7100689 0.646 rs7081889 chr10:82165427 C/A cg01528321 chr10:82214614 TSPAN14 0.84 18.27 0.59 2.57e-60 Post bronchodilator FEV1; BRCA cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg08027265 chr7:2291960 NA -0.4 -9.57 -0.35 2.32e-20 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7246760 0.867 rs58461110 chr19:9833390 G/A cg16876255 chr19:9731953 ZNF561 0.64 7.92 0.3 1.07e-14 Pursuit maintenance gain; BRCA cis rs1691799 0.899 rs1183272 chr12:66735421 T/C cg16791601 chr12:66731901 HELB -0.7 -19.95 -0.62 3.14e-69 White blood cell count (basophil); BRCA cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg21535247 chr6:8435926 SLC35B3 0.4 9.0 0.34 2.57e-18 Motion sickness; BRCA cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg00074818 chr8:8560427 CLDN23 0.38 8.36 0.31 4.03e-16 Obesity-related traits; BRCA cis rs9640161 0.789 rs3735172 chr7:150028958 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 0.53 13.44 0.47 1.93e-36 Blood protein levels;Circulating chemerin levels; BRCA cis rs243505 0.898 rs243537 chr7:148408278 A/G cg09806900 chr7:148480153 CUL1 -0.43 -8.64 -0.32 4.55e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg11266682 chr4:10021025 SLC2A9 -0.41 -11.09 -0.4 3.03e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg12564285 chr5:131593104 PDLIM4 0.46 12.25 0.44 3.94e-31 Acylcarnitine levels; BRCA cis rs11608355 0.515 rs61941591 chr12:109919965 A/C cg05360138 chr12:110035743 NA 0.74 13.58 0.47 4.43e-37 Neuroticism; BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.29 9.85 0.36 2.12e-21 Bipolar disorder; BRCA trans rs9291683 0.552 rs11736410 chr4:10017241 G/A cg26043149 chr18:55253948 FECH 0.39 8.33 0.31 4.89e-16 Bone mineral density; BRCA trans rs7829975 0.564 rs2921060 chr8:8317817 G/T cg21775007 chr8:11205619 TDH -0.42 -8.69 -0.33 3.15e-17 Mood instability; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.88 17.25 0.56 4.8e-55 Alzheimer's disease; BRCA trans rs6479891 1.000 rs59246603 chr10:65233942 T/C cg14819942 chr15:35414228 NA 0.35 8.69 0.33 3.04e-17 Arthritis (juvenile idiopathic); BRCA cis rs6831352 0.918 rs17218141 chr4:100055908 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg23583168 chr7:148888333 NA -0.84 -19.93 -0.62 4.16e-69 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7103648 1.000 rs12292911 chr11:47449072 C/T cg20307385 chr11:47447363 PSMC3 0.9 27.71 0.74 1.27e-111 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6088580 0.634 rs6059897 chr20:33113224 A/G cg24642439 chr20:33292090 TP53INP2 0.53 11.65 0.42 1.42e-28 Glomerular filtration rate (creatinine); BRCA cis rs11190604 0.767 rs3750723 chr10:102172989 T/C cg07080220 chr10:102295463 HIF1AN 0.49 10.03 0.37 4.26e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10227331 0.846 rs10807647 chr7:157298007 A/G cg04156418 chr7:157293606 NA -0.33 -9.48 -0.35 4.84e-20 Inattentive symptoms; BRCA cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.7 0.39 1.04e-24 Motion sickness; BRCA cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 3.95e-25 Bipolar disorder; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg18765753 chr7:1198926 ZFAND2A -0.38 -8.87 -0.33 7.23e-18 Longevity;Endometriosis; BRCA cis rs11792861 0.591 rs11791855 chr9:111684139 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.56 12.38 0.44 1.1e-31 Menarche (age at onset); BRCA cis rs427394 0.802 rs274698 chr5:6730957 T/G cg10857441 chr5:6722123 POLS -0.33 -10.94 -0.4 1.16e-25 Menopause (age at onset); BRCA cis rs7267979 1.000 rs6050566 chr20:25351071 G/A cg08601574 chr20:25228251 PYGB -0.35 -8.64 -0.32 4.54e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs832540 0.931 rs331499 chr5:56210923 C/T cg24531977 chr5:56204891 C5orf35 -0.4 -8.06 -0.3 3.86e-15 Coronary artery disease; BRCA cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.04 0.34 1.9e-18 Motion sickness; BRCA trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg15934090 chr1:100435551 SLC35A3 0.36 8.38 0.31 3.28e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs514406 0.929 rs555741 chr1:53318851 T/G cg01802117 chr1:53393560 SCP2 -0.36 -8.39 -0.31 3.16e-16 Monocyte count; BRCA cis rs965469 1.000 rs2236123 chr20:3305305 C/G cg25506879 chr20:3388711 C20orf194 0.51 9.96 0.37 7.89e-22 IFN-related cytopenia; BRCA trans rs2739330 0.796 rs5760106 chr22:24250645 A/C cg06437703 chr8:37914619 EIF4EBP1 0.31 8.13 0.31 2.19e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg18230493 chr5:56204884 C5orf35 -0.72 -14.07 -0.49 2.27e-39 Initial pursuit acceleration; BRCA cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg14500267 chr11:67383377 NA -0.4 -8.42 -0.32 2.42e-16 Mean corpuscular volume; BRCA cis rs4076764 0.801 rs6698738 chr1:163359918 G/A cg24596788 chr1:163392923 NA -0.33 -8.91 -0.33 5.14e-18 Motion sickness; BRCA cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.88 0.56 3.83e-53 Bladder cancer; BRCA cis rs7851660 0.870 rs1867278 chr9:100615949 C/A cg13688889 chr9:100608707 NA -0.36 -8.72 -0.33 2.42e-17 Strep throat; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.62 -0.32 5.36e-17 Total body bone mineral density; BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg13880726 chr7:1868755 MAD1L1 0.5 10.15 0.37 1.57e-22 Bipolar disorder and schizophrenia; BRCA cis rs365132 0.875 rs2454952 chr5:176376493 C/T cg16309518 chr5:176445507 NA -0.4 -9.8 -0.36 3.21e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7523050 0.730 rs35100394 chr1:109433989 C/G cg08274380 chr1:109419600 GPSM2 1.18 16.83 0.55 6.67e-53 Fat distribution (HIV); BRCA trans rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05039488 chr6:79577232 IRAK1BP1 0.36 8.07 0.3 3.49e-15 Endometrial cancer; BRCA cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg01939980 chr4:1354348 KIAA1530 0.37 8.79 0.33 1.41e-17 Obesity-related traits; BRCA cis rs7927771 0.832 rs11607981 chr11:47401060 T/G cg20307385 chr11:47447363 PSMC3 -0.4 -8.48 -0.32 1.52e-16 Subjective well-being; BRCA cis rs7824557 0.564 rs13260727 chr8:11232860 A/G cg21775007 chr8:11205619 TDH 0.58 12.73 0.45 2.93e-33 Retinal vascular caliber; BRCA cis rs1843834 0.574 rs6436499 chr2:225456551 A/T cg22455342 chr2:225449267 CUL3 0.63 16.09 0.54 3.88e-49 IgE levels in asthmatics (D.p. specific); BRCA cis rs7020830 0.825 rs7036132 chr9:37317241 A/G cg14294708 chr9:37120828 ZCCHC7 1.17 37.68 0.83 1.76e-164 Schizophrenia; BRCA trans rs6582630 0.537 rs8189533 chr12:38391068 A/G cg06521331 chr12:34319734 NA -0.51 -9.14 -0.34 8.14e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs7580658 0.963 rs867304 chr2:128078488 G/A cg09760422 chr2:128146352 NA -0.35 -7.93 -0.3 1e-14 Protein C levels; BRCA cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.42 -7.83 -0.3 1.99e-14 Renal function-related traits (BUN); BRCA cis rs17376456 0.825 rs36042718 chr5:93180997 C/T cg25358565 chr5:93447407 FAM172A 1.18 17.69 0.57 2.68e-57 Diabetic retinopathy; BRCA cis rs11227306 0.934 rs2303385 chr11:65640562 G/A cg00576331 chr11:65640516 EFEMP2 0.44 9.83 0.36 2.59e-21 DNA methylation (variation); BRCA cis rs2249625 0.545 rs2496495 chr6:72882414 G/A cg18830697 chr6:72922368 RIMS1 -0.63 -14.36 -0.49 9.82e-41 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg04450456 chr4:17643702 FAM184B 0.37 10.55 0.39 4.13e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs61931739 0.500 rs10772163 chr12:34532950 T/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA trans rs1391576 1 rs1391576 chr11:51394932 C/T cg03929089 chr4:120376271 NA 0.6 8.05 0.3 3.99e-15 Body mass index; BRCA cis rs425277 0.585 rs364677 chr1:2071765 A/G cg19257562 chr1:2043853 PRKCZ 0.35 9.83 0.36 2.41e-21 Height; BRCA cis rs3733585 0.673 rs4467564 chr4:9953472 G/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.74e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9914988 0.943 rs4794838 chr17:27131095 T/C cg20469991 chr17:27169893 C17orf63 -0.44 -8.48 -0.32 1.51e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg01579765 chr21:45077557 HSF2BP -0.42 -11.57 -0.42 3.11e-28 Mean corpuscular volume; BRCA cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg13660082 chr14:53194042 PSMC6 -0.56 -8.03 -0.3 4.85e-15 Alzheimer's disease (late onset); BRCA trans rs6089829 0.888 rs4809468 chr20:61673566 T/C cg17470723 chr8:74884337 TCEB1 0.39 8.14 0.31 2.15e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2011503 0.739 rs8108659 chr19:19680738 T/A cg15839431 chr19:19639596 YJEFN3 0.38 8.35 0.31 4.09e-16 Bipolar disorder; BRCA cis rs10872587 0.657 rs11155459 chr6:146578751 A/G cg23711669 chr6:146136114 FBXO30 -0.49 -8.95 -0.33 3.98e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg23029597 chr12:123009494 RSRC2 -0.57 -11.76 -0.42 4.89e-29 Body mass index; BRCA cis rs832540 0.669 rs832538 chr5:56200016 C/T cg24531977 chr5:56204891 C5orf35 -0.64 -14.03 -0.49 3.5e-39 Coronary artery disease; BRCA cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg23029597 chr12:123009494 RSRC2 -0.63 -12.86 -0.45 8.4e-34 Body mass index; BRCA cis rs9325144 0.555 rs11183215 chr12:38693127 G/A cg13010199 chr12:38710504 ALG10B -0.39 -8.85 -0.33 8.41e-18 Morning vs. evening chronotype; BRCA cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg01579765 chr21:45077557 HSF2BP -0.38 -10.03 -0.37 4.32e-22 Mean corpuscular volume; BRCA cis rs10193935 0.901 rs10202848 chr2:42515661 A/G cg27598129 chr2:42591480 NA -0.88 -14.14 -0.49 1.05e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg12667521 chr19:29218732 NA 0.47 8.75 0.33 1.93e-17 Methadone dose in opioid dependence; BRCA cis rs2637266 1.000 rs7896831 chr10:78366649 A/T cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs243505 0.894 rs243504 chr7:148435393 A/G cg09806900 chr7:148480153 CUL1 -0.4 -8.44 -0.32 2.1e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs853679 0.546 rs200948 chr6:27835272 T/C cg26587870 chr6:27730563 NA -0.55 -8.23 -0.31 1.08e-15 Depression; BRCA trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.86 0.3 1.6e-14 Corneal astigmatism; BRCA cis rs2425143 1.000 rs73902914 chr20:34432882 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.88 -0.33 6.76e-18 Blood protein levels; BRCA cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg23029597 chr12:123009494 RSRC2 -0.58 -11.28 -0.41 4.73e-27 Body mass index; BRCA trans rs17685 0.753 rs1104878 chr7:75685593 G/T cg19862616 chr7:65841803 NCRNA00174 0.85 28.34 0.75 4.9e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs965469 0.948 rs2236094 chr20:3260368 C/G cg25506879 chr20:3388711 C20orf194 0.53 10.82 0.39 3.56e-25 IFN-related cytopenia; BRCA cis rs829883 0.659 rs11109522 chr12:98930964 C/T cg25150519 chr12:98850993 NA -0.5 -9.1 -0.34 1.1e-18 Colorectal adenoma (advanced); BRCA trans rs7819412 0.594 rs17724226 chr8:10968926 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -8.55 -0.32 8.78e-17 Triglycerides; BRCA cis rs12310956 0.532 rs11052922 chr12:33957476 A/G cg06521331 chr12:34319734 NA -0.54 -10.84 -0.39 3.04e-25 Morning vs. evening chronotype; BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs698833 0.926 rs786624 chr2:44604941 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.47 -9.46 -0.35 5.71e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7246657 0.943 rs10409204 chr19:37917692 G/A cg18154014 chr19:37997991 ZNF793 0.6 11.29 0.41 4.35e-27 Coronary artery calcification; BRCA cis rs586533 0.958 rs682120 chr11:99526433 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.85 0.3 1.82e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs1784581 0.775 rs7755404 chr6:162427731 T/C cg17173639 chr6:162384350 PARK2 0.39 9.16 0.34 7.23e-19 Itch intensity from mosquito bite; BRCA cis rs68170813 0.559 rs4730239 chr7:107056960 A/T cg02696742 chr7:106810147 HBP1 -0.54 -8.13 -0.31 2.17e-15 Coronary artery disease; BRCA cis rs6973256 0.605 rs10227672 chr7:133326196 G/C cg07491979 chr7:133331646 EXOC4 -0.35 -7.89 -0.3 1.33e-14 Intelligence (multi-trait analysis); BRCA cis rs11711311 1.000 rs2566963 chr3:113531849 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.32 -8.3 -0.31 6.35e-16 IgG glycosylation; BRCA cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg21535247 chr6:8435926 SLC35B3 0.38 8.72 0.33 2.34e-17 Motion sickness; BRCA cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs12586317 0.547 rs112510746 chr14:35491833 T/G cg16230307 chr14:35515116 FAM177A1 0.73 15.06 0.51 4.55e-44 Psoriasis; BRCA trans rs853679 0.546 rs35017208 chr6:28345282 C/T cg01620082 chr3:125678407 NA -0.97 -10.99 -0.4 7.12e-26 Depression; BRCA cis rs2576037 0.583 rs11659693 chr18:44458733 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.9 -0.4 1.79e-25 Personality dimensions; BRCA cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 14.93 0.51 1.86e-43 Colorectal cancer; BRCA cis rs2730245 1.000 rs2252502 chr7:158738634 G/C cg14689365 chr7:158441557 NCAPG2 -0.42 -8.59 -0.32 6.72e-17 Height; BRCA cis rs8103278 1.000 rs8102876 chr19:46332842 C/T cg11657440 chr19:46296263 DMWD -0.55 -12.75 -0.45 2.44e-33 Coronary artery disease; BRCA cis rs1153858 1.000 rs60476496 chr15:45713801 C/T cg21132104 chr15:45694354 SPATA5L1 0.74 16.35 0.54 1.82e-50 Homoarginine levels; BRCA cis rs1348850 0.626 rs1901825 chr2:178225331 A/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.4 8.28 0.31 6.96e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg26314531 chr2:26401878 FAM59B -0.65 -11.1 -0.4 2.59e-26 Gut microbiome composition (summer); BRCA cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg00409905 chr10:38381863 ZNF37A 0.45 9.16 0.34 6.75e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs708547 0.836 rs781554 chr4:57717537 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.48 -10.36 -0.38 2.42e-23 Response to bleomycin (chromatid breaks); BRCA cis rs921968 0.519 rs62191659 chr2:219630510 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.96 -0.4 9.54e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9517313 0.551 rs2274051 chr13:99091634 A/G cg07423050 chr13:99094983 FARP1 0.63 15.82 0.53 8.3e-48 Neuroticism; BRCA cis rs509477 1.000 rs7240845 chr18:32574960 G/C cg23791764 chr18:32556832 MAPRE2 -0.34 -7.82 -0.3 2.26e-14 Cerebrospinal fluid AB1-42 levels; BRCA trans rs11088226 0.681 rs2833911 chr21:33949629 C/T cg09050820 chr6:167586206 TCP10L2 -0.83 -15.43 -0.52 6.66e-46 Gastritis; BRCA cis rs826838 0.868 rs12322306 chr12:39130021 A/G cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs826838 0.933 rs980573 chr12:39127811 T/C cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs7666738 0.830 rs7664169 chr4:99037859 C/T cg17366294 chr4:99064904 C4orf37 -0.45 -10.67 -0.39 1.4e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1882538 0.506 rs7805858 chr7:133126589 G/T cg10665199 chr7:133106180 EXOC4 0.43 9.05 0.34 1.66e-18 Intelligence (multi-trait analysis); BRCA cis rs9527 0.641 rs34130454 chr10:104903638 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.73 0.39 8.24e-25 Arsenic metabolism; BRCA cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.43 0.32 2.37e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg06784218 chr1:46089804 CCDC17 -0.47 -11.14 -0.4 1.91e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3733585 0.806 rs11723382 chr4:9954660 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -13.5 -0.47 1.05e-36 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6142102 0.538 rs6142058 chr20:32542801 A/G cg24642439 chr20:33292090 TP53INP2 0.39 7.81 0.3 2.32e-14 Skin pigmentation; BRCA cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg21395723 chr22:39101663 GTPBP1 0.4 8.66 0.32 3.7e-17 Menopause (age at onset); BRCA cis rs3784262 0.669 rs4646609 chr15:58274989 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.02 -0.37 4.76e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6840360 0.593 rs10222925 chr4:152690215 A/G cg22705602 chr4:152727874 NA -0.38 -10.48 -0.38 7.89e-24 Intelligence (multi-trait analysis); BRCA cis rs2997447 0.655 rs12059101 chr1:26384013 A/G cg19633962 chr1:26362018 EXTL1 -0.61 -10.51 -0.38 6.3e-24 QRS complex (12-leadsum); BRCA cis rs7927771 0.524 rs11039329 chr11:47684908 A/G cg20307385 chr11:47447363 PSMC3 0.43 9.77 0.36 4.05e-21 Subjective well-being; BRCA cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg19729930 chr2:74357872 NA 0.54 13.68 0.48 1.57e-37 Gestational age at birth (maternal effect); BRCA cis rs4363385 0.693 rs76987906 chr1:152964530 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.54 -0.35 2.86e-20 Inflammatory skin disease; BRCA cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06544989 chr22:39130855 UNC84B -0.37 -8.97 -0.33 3.3e-18 Menopause (age at onset); BRCA cis rs4727027 0.901 rs1534197 chr7:148771970 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.36 0.38 2.33e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg04450456 chr4:17643702 FAM184B 0.38 11.09 0.4 3.02e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg24558204 chr6:135376177 HBS1L 0.59 15.94 0.53 1.98e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9790314 0.503 rs6441374 chr3:161064540 A/T cg04691961 chr3:161091175 C3orf57 -0.36 -7.96 -0.3 7.98e-15 Morning vs. evening chronotype; BRCA cis rs4689388 0.609 rs1046319 chr4:6304286 C/T cg00701064 chr4:6280414 WFS1 0.66 13.22 0.46 1.96e-35 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2617583 0.967 rs2937640 chr5:1443604 C/T cg07151155 chr5:1473589 LPCAT1 -0.38 -8.24 -0.31 1.01e-15 Breast cancer; BRCA cis rs7772486 0.875 rs7739418 chr6:146359188 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.03 0.51 5.77e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs8062405 0.964 rs78613234 chr16:28839425 T/C cg09719594 chr16:21412588 NA -0.33 -8.01 -0.3 5.43e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6878727 0.665 rs698182 chr5:123667142 C/T cg01806427 chr5:123737813 NA -0.37 -8.27 -0.31 7.92e-16 Breast cancer; BRCA cis rs858239 0.539 rs10225608 chr7:23188908 A/G cg23682824 chr7:23144976 KLHL7 0.42 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg11279151 chr3:101281821 RG9MTD1 -0.34 -7.91 -0.3 1.14e-14 Colorectal cancer; BRCA cis rs3925075 1.000 rs55742763 chr16:31340368 G/A cg02846316 chr16:31340340 ITGAM 0.55 13.57 0.47 4.64e-37 IgA nephropathy; BRCA cis rs514406 0.505 rs269290 chr1:53167027 A/T cg08859206 chr1:53392774 SCP2 -0.4 -8.63 -0.32 4.8e-17 Monocyte count; BRCA trans rs3780486 0.881 rs10738906 chr9:33135634 T/C cg04842962 chr6:43655489 MRPS18A 1.12 38.53 0.84 8.49e-169 IgG glycosylation; BRCA cis rs6545883 0.929 rs2593626 chr2:61665184 C/A cg15711740 chr2:61764176 XPO1 -0.56 -14.22 -0.49 4.62e-40 Tuberculosis; BRCA cis rs10949834 0.517 rs810536 chr7:73504233 G/A cg07137043 chr7:73588983 EIF4H 0.5 8.92 0.33 4.97e-18 Verbal memory performance (residualized delayed recall change); BRCA cis rs10411936 0.712 rs9305079 chr19:16591464 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.45 9.52 0.35 3.45e-20 White blood cell count;Multiple sclerosis; BRCA trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg15556689 chr8:8085844 FLJ10661 -0.36 -9.04 -0.34 1.79e-18 Retinal vascular caliber; BRCA cis rs34779708 0.931 rs4934711 chr10:35360310 G/A cg03585969 chr10:35415529 CREM 0.48 10.32 0.38 3.39e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg12935359 chr14:103987150 CKB 0.64 15.0 0.51 8.63e-44 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg07636037 chr3:49044803 WDR6 0.98 29.0 0.75 1.13e-118 Parkinson's disease; BRCA cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg07828340 chr4:882639 GAK 1.0 11.93 0.43 9.13e-30 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.56e-17 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.534 rs35056575 chr12:34142914 A/T cg06521331 chr12:34319734 NA -0.63 -11.49 -0.41 6.87e-28 Morning vs. evening chronotype; BRCA cis rs861020 1.000 rs595918 chr1:209966843 A/G cg05527609 chr1:210001259 C1orf107 0.65 14.06 0.49 2.5e-39 Orofacial clefts; BRCA cis rs76419734 0.510 rs2544402 chr4:106687733 A/G cg24545054 chr4:106630052 GSTCD;INTS12 -0.44 -9.49 -0.35 4.45e-20 Post bronchodilator FEV1; BRCA cis rs2204008 0.754 rs11514074 chr12:38401128 C/T cg26384229 chr12:38710491 ALG10B 0.77 17.28 0.56 3.33e-55 Bladder cancer; BRCA cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg04317338 chr11:64019027 PLCB3 0.55 9.58 0.35 2.08e-20 Mean platelet volume; BRCA cis rs2806561 0.664 rs4620508 chr1:23307438 C/T cg19743168 chr1:23544995 NA 0.34 8.02 0.3 4.91e-15 Height; BRCA cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg08645402 chr16:4508243 NA 0.42 9.62 0.36 1.47e-20 Schizophrenia; BRCA cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.65 -0.32 4.13e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6429082 0.871 rs9662392 chr1:235576949 G/T cg26050004 chr1:235667680 B3GALNT2 -0.34 -8.09 -0.3 3.01e-15 Adiposity; BRCA trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg15704280 chr7:45808275 SEPT13 0.53 8.97 0.33 3.33e-18 Axial length; BRCA cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg11822812 chr5:140052017 DND1 -0.31 -8.46 -0.32 1.82e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs7975161 0.671 rs7313063 chr12:104602208 G/A cg25273343 chr12:104657179 TXNRD1 -0.39 -9.29 -0.34 2.36e-19 Toenail selenium levels; BRCA cis rs13191362 1.000 rs66534429 chr6:163003322 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.04 0.43 2.96e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6910061 0.957 rs6916541 chr6:11095258 C/A cg27233058 chr6:11094804 LOC221710 0.52 9.24 0.34 3.71e-19 Diabetic kidney disease; BRCA cis rs3849570 0.925 rs6799080 chr3:81905591 G/A cg07356753 chr3:81810745 GBE1 -0.43 -10.25 -0.38 6.45e-23 Waist circumference;Body mass index; BRCA cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg24562669 chr7:97807699 LMTK2 0.43 11.66 0.42 1.3e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs7246657 0.722 rs16958863 chr19:38124235 A/G cg23950597 chr19:37808831 NA -0.48 -8.35 -0.31 4.2e-16 Coronary artery calcification; BRCA cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg13319975 chr6:146136371 FBXO30 0.39 8.98 0.33 2.92e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs9486719 1.000 rs11153064 chr6:97021959 A/G cg06623918 chr6:96969491 KIAA0776 -0.77 -13.77 -0.48 5.7800000000000005e-38 Migraine;Coronary artery disease; BRCA cis rs6121246 0.821 rs7265413 chr20:30317923 G/A cg13852791 chr20:30311386 BCL2L1 0.85 16.77 0.55 1.43e-52 Mean corpuscular hemoglobin; BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.65 10.72 0.39 9.05e-25 Renal function-related traits (BUN); BRCA cis rs9814567 1.000 rs4955485 chr3:134295843 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.02 -0.34 2.21e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.73e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs208520 1.000 rs9453663 chr6:66976077 A/G cg07460842 chr6:66804631 NA 0.68 11.41 0.41 1.47e-27 Exhaled nitric oxide output; BRCA cis rs965469 1.000 rs6037553 chr20:3313884 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.35 -0.38 2.54e-23 IFN-related cytopenia; BRCA cis rs2404618 0.587 rs6994849 chr8:1492839 G/T cg13402656 chr8:1511478 DLGAP2 0.54 11.74 0.42 5.64e-29 Lung cancer; BRCA cis rs3820928 0.904 rs4439949 chr2:227764954 T/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.77e-16 Pulmonary function; BRCA cis rs1062746 0.738 rs2303764 chr16:87377455 C/G cg02258303 chr16:87377426 FBXO31 0.36 7.9 0.3 1.25e-14 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy); BRCA cis rs12618769 0.597 rs72821924 chr2:99114924 C/T cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs9733 0.818 rs7520022 chr1:150659173 C/G cg13175981 chr1:150552382 MCL1 0.45 10.1 0.37 2.37e-22 Tonsillectomy; BRCA cis rs36051895 0.632 rs12337480 chr9:5134567 T/A cg02405213 chr9:5042618 JAK2 -0.46 -9.01 -0.34 2.43e-18 Pediatric autoimmune diseases; BRCA cis rs1707322 0.964 rs7546237 chr1:46285610 A/C cg03146154 chr1:46216737 IPP 0.45 9.89 0.36 1.46e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs561341 1.000 rs113676348 chr17:30244327 A/G cg27661571 chr11:113659931 NA -0.69 -10.98 -0.4 7.83e-26 Hip circumference adjusted for BMI; BRCA cis rs17270561 0.609 rs4711097 chr6:25732314 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.89 0.33 6.19e-18 Iron status biomarkers; BRCA cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg17063962 chr7:91808500 NA 0.53 12.51 0.44 2.79e-32 Breast cancer; BRCA cis rs68170813 0.559 rs1548524 chr7:106944563 G/T cg02696742 chr7:106810147 HBP1 0.54 9.08 0.34 1.38e-18 Coronary artery disease; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg18402987 chr7:1209562 NA 0.59 9.12 0.34 9.34e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs738322 0.967 rs132985 chr22:38563471 C/T cg20207973 chr22:38506712 BAIAP2L2 0.31 8.05 0.3 4.16e-15 Cutaneous nevi; BRCA cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.97 0.33 3.36e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg20848291 chr7:100343083 ZAN -0.61 -12.92 -0.46 4.1e-34 Other erythrocyte phenotypes; BRCA cis rs74181299 0.684 rs17040050 chr2:65327042 G/A cg05010058 chr2:65284262 CEP68 -0.29 -7.91 -0.3 1.16e-14 Pulse pressure; BRCA cis rs67460515 0.892 rs34016896 chr3:160992864 C/T cg03342759 chr3:160939853 NMD3 -0.8 -17.94 -0.58 1.44e-58 Parkinson's disease; BRCA cis rs13223928 0.651 rs4722435 chr7:3152962 C/T cg19214707 chr7:3157722 NA 0.45 11.36 0.41 2.21e-27 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.65 13.72 0.48 1.03e-37 Lymphocyte counts; BRCA cis rs6987853 0.761 rs2974321 chr8:42424727 A/G cg09913449 chr8:42400586 C8orf40 0.42 9.34 0.35 1.62e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs6545883 0.965 rs6718887 chr2:61727215 G/A cg15711740 chr2:61764176 XPO1 -0.52 -13.1 -0.46 6.71e-35 Tuberculosis; BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg03609598 chr5:56110824 MAP3K1 -0.49 -8.35 -0.31 4.37e-16 Type 2 diabetes; BRCA cis rs1153858 1.000 rs10519022 chr15:45663684 C/T cg14582100 chr15:45693742 SPATA5L1 -0.35 -11.44 -0.41 1.07e-27 Homoarginine levels; BRCA cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.17 0.62 2.23e-70 Chronic sinus infection; BRCA cis rs16910800 0.731 rs16910754 chr11:23192015 A/G cg20040320 chr11:23191996 NA 0.59 10.08 0.37 2.84e-22 Cancer; BRCA cis rs950776 0.518 rs55690619 chr15:78833612 A/G cg06917634 chr15:78832804 PSMA4 -0.76 -17.67 -0.57 3.29e-57 Sudden cardiac arrest; BRCA cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.45 0.47 1.79e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12618769 0.597 rs72821946 chr2:99142411 G/C cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA cis rs1113500 1.000 rs1777483 chr1:108609408 A/C cg06207961 chr1:108661230 NA -0.42 -10.48 -0.38 7.97e-24 Growth-regulated protein alpha levels; BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg22963979 chr7:1858916 MAD1L1 -0.4 -8.45 -0.32 1.91e-16 Bipolar disorder and schizophrenia; BRCA cis rs9467773 0.595 rs2451736 chr6:26620544 G/A cg11502198 chr6:26597334 ABT1 0.56 12.04 0.43 3.01e-30 Intelligence (multi-trait analysis); BRCA cis rs56104184 0.830 rs73061617 chr19:49350984 G/A cg15549821 chr19:49342101 PLEKHA4 -1.05 -15.64 -0.53 6.44e-47 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs10170846 1.000 rs10170846 chr2:223517705 C/G cg25565276 chr2:223520875 FARSB -0.5 -13.49 -0.47 1.08e-36 Schizophrenia (inflammation and infection response interaction); BRCA cis rs12220238 1.000 rs10824083 chr10:75911342 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.5 8.09 0.3 3.05e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs4077515 0.967 rs11794847 chr9:139271747 G/A cg14019695 chr9:139328340 INPP5E 0.32 8.1 0.31 2.7e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.63 0.32 4.9e-17 Rheumatoid arthritis; BRCA cis rs881375 0.933 rs7021206 chr9:123684157 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.49 -10.63 -0.39 2.09e-24 Rheumatoid arthritis; BRCA cis rs10927875 0.541 rs1763601 chr1:16340460 G/T cg06159980 chr1:16340746 HSPB7 -0.38 -8.84 -0.33 9.14e-18 Dilated cardiomyopathy; BRCA cis rs941408 1.000 rs2260416 chr19:2796355 G/A cg06609049 chr19:2785107 THOP1 0.59 12.03 0.43 3.39e-30 Total cholesterol levels; BRCA cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11644478 chr21:40555479 PSMG1 -0.51 -10.69 -0.39 1.23e-24 Menarche (age at onset); BRCA trans rs60843830 0.633 rs1078763 chr2:113763 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.44 -8.99 -0.34 2.89e-18 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg13770153 chr20:60521292 NA -0.38 -9.13 -0.34 8.72e-19 Body mass index; BRCA cis rs2075371 0.931 rs1646697 chr7:133999930 G/A cg02659138 chr7:134003124 SLC35B4 0.34 10.79 0.39 4.94e-25 Mean platelet volume; BRCA cis rs875971 0.929 rs778692 chr7:65872449 A/G cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.33e-67 Aortic root size; BRCA cis rs6430585 0.528 rs6711493 chr2:136692553 A/G cg07169764 chr2:136633963 MCM6 0.96 19.26 0.61 1.57e-65 Corneal structure; BRCA cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.21 0.37 9.18e-23 Aortic root size; BRCA trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.52 -0.32 1.16e-16 Extrinsic epigenetic age acceleration; BRCA cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg18351406 chr4:77819688 ANKRD56 0.61 13.39 0.47 3.13e-36 Emphysema distribution in smoking; BRCA cis rs6088590 0.603 rs6579186 chr20:33282198 G/C cg08999081 chr20:33150536 PIGU 0.44 11.74 0.42 6.07e-29 Coronary artery disease; BRCA cis rs853679 0.517 rs9380062 chr6:28137569 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs9815354 1.000 rs9823254 chr3:41894768 G/C cg03022575 chr3:42003672 ULK4 0.51 8.28 0.31 6.99e-16 Pulse pressure;Diastolic blood pressure; BRCA cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs3772130 0.583 rs34051021 chr3:121433005 C/A cg20356878 chr3:121714668 ILDR1 0.37 8.27 0.31 7.51e-16 Cognitive performance; BRCA cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs3772130 0.564 rs4420917 chr3:121567863 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.27 0.49 2.71e-40 Cognitive performance; BRCA cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg18357645 chr12:58087776 OS9 0.42 11.95 0.43 7.78e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs7267979 1.000 rs6076336 chr20:25319212 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.23e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg12373951 chr3:133503437 NA -0.45 -10.63 -0.39 1.98e-24 Iron status biomarkers; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg12444411 chr7:2802554 GNA12 -0.38 -9.5 -0.35 3.99e-20 Height; BRCA cis rs9462846 0.919 rs9471966 chr6:42891022 G/A cg02353165 chr6:42928485 GNMT 0.49 9.58 0.35 2.02e-20 Blood protein levels; BRCA cis rs775227 0.574 rs2018912 chr3:113060140 A/G cg18753928 chr3:113234510 CCDC52 -0.55 -9.21 -0.34 4.67e-19 Dental caries; BRCA cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.22 -0.31 1.12e-15 Total body bone mineral density; BRCA cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg03146154 chr1:46216737 IPP 0.52 11.79 0.42 3.75e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs250677 0.687 rs41181 chr5:148444257 C/G cg18129178 chr5:148520854 ABLIM3 0.58 11.69 0.42 9.92e-29 Breast cancer; BRCA cis rs7119 0.717 rs8032071 chr15:77745762 C/T cg17802220 chr15:77601643 NA 0.47 10.32 0.38 3.38e-23 Type 2 diabetes; BRCA trans rs208520 0.674 rs207103 chr6:66795568 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.86 0.39 2.45e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs78456975 0.527 rs11886696 chr2:1567841 A/G cg01028140 chr2:1542097 TPO -0.61 -12.55 -0.44 1.95e-32 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7809950 0.678 rs7788271 chr7:106985873 A/G cg23024343 chr7:107201750 COG5 -0.48 -9.58 -0.35 2.03e-20 Coronary artery disease; BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg13047869 chr3:10149882 C3orf24 0.53 9.73 0.36 5.63e-21 Alzheimer's disease; BRCA cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg11764359 chr7:65958608 NA 0.77 17.23 0.56 6.13e-55 Aortic root size; BRCA cis rs1451375 0.669 rs4512339 chr7:50646977 C/T cg18232548 chr7:50535776 DDC -0.37 -8.67 -0.32 3.54e-17 Malaria; BRCA cis rs911555 0.692 rs7146215 chr14:103915908 A/G cg12935359 chr14:103987150 CKB 0.65 15.1 0.51 2.88e-44 Intelligence (multi-trait analysis); BRCA cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg22875332 chr1:76189707 ACADM 0.7 14.85 0.51 4.36e-43 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs629535 0.547 rs62513420 chr8:70122597 G/A cg21567404 chr3:27674614 NA -0.96 -17.52 -0.57 2.15e-56 Dupuytren's disease; BRCA cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg02297831 chr4:17616191 MED28 0.36 8.53 0.32 1.07e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg04727924 chr7:799746 HEATR2 -0.54 -10.52 -0.38 5.8e-24 Cerebrospinal P-tau181p levels; BRCA cis rs7809950 1.000 rs4727684 chr7:107226470 C/T cg23024343 chr7:107201750 COG5 -0.44 -9.64 -0.36 1.23e-20 Coronary artery disease; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 18.11 0.58 1.82e-59 Platelet count; BRCA cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg21395723 chr22:39101663 GTPBP1 0.38 8.22 0.31 1.15e-15 Menopause (age at onset); BRCA cis rs9527 0.641 rs4919684 chr10:104587024 A/G cg04362960 chr10:104952993 NT5C2 0.47 10.12 0.37 1.97e-22 Arsenic metabolism; BRCA cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg04896959 chr15:78267971 NA -0.63 -17.3 -0.56 2.64e-55 Diastolic blood pressure; BRCA trans rs61931739 0.500 rs11519398 chr12:34473553 C/T cg26384229 chr12:38710491 ALG10B 0.76 16.09 0.54 3.75e-49 Morning vs. evening chronotype; BRCA cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg24110177 chr3:50126178 RBM5 0.42 11.53 0.41 4.63e-28 Intelligence (multi-trait analysis); BRCA cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg04990556 chr1:26633338 UBXN11 -0.76 -18.66 -0.59 2.45e-62 Obesity-related traits; BRCA cis rs10789491 0.588 rs2099766 chr1:47193987 T/C cg15501359 chr1:47185051 KIAA0494 0.64 15.96 0.53 1.74e-48 Response to hepatitis C treatment; BRCA cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.4 -8.67 -0.32 3.5e-17 Educational attainment; BRCA cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg24110177 chr3:50126178 RBM5 0.51 14.43 0.5 4.75e-41 Body mass index; BRCA cis rs1505368 0.836 rs10201067 chr2:213284411 A/G cg16329650 chr2:213403929 ERBB4 -0.34 -8.34 -0.31 4.61e-16 Symmetrical dimethylarginine levels; BRCA cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg06108461 chr20:60628389 TAF4 -0.96 -21.32 -0.64 1.44e-76 Body mass index; BRCA cis rs798554 0.679 rs798499 chr7:2792013 G/A cg09658497 chr7:2847517 GNA12 -0.41 -8.6 -0.32 6.16e-17 Height; BRCA cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg24562669 chr7:97807699 LMTK2 0.45 12.08 0.43 2.16e-30 Prostate cancer (SNP x SNP interaction); BRCA trans rs2018683 0.624 rs6462119 chr7:29003725 G/C cg19402173 chr7:128379420 CALU -0.48 -11.66 -0.42 1.34e-28 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -8.14 -0.31 2.14e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12545109 1.000 rs2217957 chr8:57313360 T/C cg09654669 chr8:57350985 NA -0.42 -9.15 -0.34 7.71e-19 Obesity-related traits; BRCA cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.07 0.4 3.57e-26 Electroencephalogram traits; BRCA cis rs7918232 0.882 rs788211 chr10:27479070 C/T cg14240646 chr10:27532245 ACBD5 0.69 10.82 0.39 3.48e-25 Breast cancer; BRCA cis rs965469 0.652 rs4507156 chr20:3228460 A/G cg25506879 chr20:3388711 C20orf194 0.48 9.97 0.37 7.45e-22 IFN-related cytopenia; BRCA cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.73 21.3 0.64 1.69e-76 Age-related macular degeneration (geographic atrophy); BRCA trans rs11098499 0.863 rs10034450 chr4:120455649 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs4566357 0.615 rs10190621 chr2:227914484 A/G cg11843606 chr2:227700838 RHBDD1 -0.43 -9.59 -0.35 1.95e-20 Coronary artery disease; BRCA cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg24296786 chr1:45957014 TESK2 0.6 14.53 0.5 1.53e-41 High light scatter reticulocyte count; BRCA cis rs7568458 0.636 rs11126995 chr2:85792408 A/T cg02493740 chr2:85810744 VAMP5 -0.55 -11.34 -0.41 2.68e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7818345 0.967 rs12679712 chr8:19271032 C/G cg11303988 chr8:19266685 CSGALNACT1 0.32 8.44 0.32 2.06e-16 Language performance in older adults (adjusted for episodic memory); BRCA trans rs9291683 1.000 rs9291683 chr4:10324160 C/T cg26043149 chr18:55253948 FECH 0.38 8.31 0.31 5.95e-16 Bone mineral density; BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg24829409 chr8:58192753 C8orf71 0.48 8.04 0.3 4.23e-15 Developmental language disorder (linguistic errors); BRCA cis rs7552167 0.925 rs78312791 chr1:24513613 C/A cg01960748 chr1:24522592 NA 0.66 10.72 0.39 9.08e-25 Psoriasis vulgaris; BRCA cis rs4780401 0.609 rs9924522 chr16:11816852 C/A cg01061890 chr16:11836724 TXNDC11 -0.56 -13.21 -0.46 2.03e-35 Rheumatoid arthritis; BRCA cis rs208515 0.525 rs10455593 chr6:66691341 C/T cg07460842 chr6:66804631 NA 0.87 15.61 0.53 8.61e-47 Exhaled nitric oxide levels; BRCA cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg02196655 chr2:10830764 NOL10 -0.3 -7.99 -0.3 6.45e-15 Prostate cancer; BRCA cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg00825309 chr19:58991885 ZNF446 -0.59 -12.86 -0.45 7.7e-34 Uric acid clearance; BRCA cis rs2880765 0.835 rs56406982 chr15:86036379 G/A cg10818794 chr15:86012489 AKAP13 -0.31 -8.56 -0.32 8.12e-17 Coronary artery disease; BRCA cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26314531 chr2:26401878 FAM59B 0.67 12.17 0.43 8.43e-31 Gut microbiome composition (summer); BRCA cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg00339695 chr16:24857497 SLC5A11 -0.52 -11.36 -0.41 2.25e-27 Intelligence (multi-trait analysis); BRCA cis rs11676348 0.846 rs6723449 chr2:218997580 C/T cg00012203 chr2:219082015 ARPC2 0.42 8.17 0.31 1.7e-15 Ulcerative colitis; BRCA cis rs1595825 0.891 rs76308665 chr2:198518062 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -8.2 -0.31 1.28e-15 Ulcerative colitis; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19717773 chr7:2847554 GNA12 -0.4 -7.82 -0.3 2.13e-14 Height; BRCA cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg15839431 chr19:19639596 YJEFN3 -0.35 -7.99 -0.3 6.53e-15 Bipolar disorder; BRCA cis rs12477438 0.798 rs9679602 chr2:99577827 C/T cg08885076 chr2:99613938 TSGA10 0.6 13.5 0.47 9.7e-37 Chronic sinus infection; BRCA cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.22e-26 Bipolar disorder; BRCA cis rs875971 1.000 rs778699 chr7:65868290 G/A cg18876405 chr7:65276391 NA 0.56 13.34 0.47 5.75e-36 Aortic root size; BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 19.95 0.62 3.47e-69 Platelet count; BRCA cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg03146154 chr1:46216737 IPP -0.47 -9.99 -0.37 6.14e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs877282 0.945 rs11253397 chr10:789774 A/G cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs9467773 0.967 rs9358954 chr6:26531178 A/G cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.25 0.38 6.26e-23 Electroencephalogram traits; BRCA cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg10845886 chr2:3471009 TTC15 0.58 13.22 0.46 2.02e-35 Neurofibrillary tangles; BRCA cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg24562669 chr7:97807699 LMTK2 0.46 12.37 0.44 1.2e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs9868809 0.505 rs13316551 chr3:48745167 A/C cg00383909 chr3:49044727 WDR6 0.58 10.53 0.38 4.92e-24 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg24112000 chr20:60950667 NA -0.49 -9.33 -0.35 1.7e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs2885056 0.830 rs2018810 chr19:10669172 A/G cg04833646 chr19:10679720 CDKN2D 0.94 20.9 0.64 2.64e-74 Red cell distribution width; BRCA cis rs826838 0.967 rs4768329 chr12:39129394 T/C cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.18 0.31 1.53e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg22633769 chr20:60982531 CABLES2 0.43 8.09 0.3 3.05e-15 Colorectal cancer; BRCA cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg13010199 chr12:38710504 ALG10B 0.45 9.36 0.35 1.31e-19 Bladder cancer; BRCA cis rs2797160 1.000 rs2747724 chr6:126004935 G/A cg05901451 chr6:126070800 HEY2 -0.39 -9.49 -0.35 4.46e-20 Endometrial cancer; BRCA cis rs17270561 0.609 rs4712957 chr6:25719814 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.77 0.33 1.61e-17 Iron status biomarkers; BRCA cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.03 0.37 4.34e-22 Aortic root size; BRCA cis rs765787 0.530 rs12915804 chr15:45512562 T/C cg24006582 chr15:45444508 DUOX1 0.56 11.23 0.41 8.18e-27 Uric acid levels; BRCA cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg24450063 chr1:156163899 SLC25A44 1.09 34.65 0.81 7.51e-149 Testicular germ cell tumor; BRCA cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg05623727 chr3:50126028 RBM5 0.5 12.42 0.44 6.87e-32 Body mass index; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg21143896 chr7:2802374 GNA12 -0.38 -9.59 -0.35 1.88e-20 Height; BRCA cis rs1865760 0.865 rs1541987 chr6:25950397 A/G cg16482183 chr6:26056742 HIST1H1C -0.51 -10.48 -0.38 7.76e-24 Height; BRCA trans rs9858542 0.953 rs11706370 chr3:49441091 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -8.85 -0.33 8.61e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7618915 0.547 rs34610142 chr3:52708429 G/A cg10802521 chr3:52805072 NEK4 -0.33 -8.51 -0.32 1.19e-16 Bipolar disorder; BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg08048268 chr3:133502702 NA -0.33 -8.33 -0.31 4.86e-16 Iron status biomarkers; BRCA cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.6 -0.32 6.09e-17 Bipolar disorder; BRCA cis rs6860806 0.507 rs169256 chr5:131688533 A/G cg24060327 chr5:131705240 SLC22A5 -0.52 -8.97 -0.33 3.33e-18 Breast cancer; BRCA cis rs4076764 0.846 rs12035840 chr1:163419177 G/C cg24596788 chr1:163392923 NA -0.32 -8.44 -0.32 2.09e-16 Motion sickness; BRCA cis rs2797160 1.000 rs1935773 chr6:125996475 A/G cg05901451 chr6:126070800 HEY2 -0.45 -10.84 -0.39 2.87e-25 Endometrial cancer; BRCA cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg06212747 chr3:49208901 KLHDC8B 0.48 9.72 0.36 6.64e-21 Parkinson's disease; BRCA cis rs60843830 0.550 rs300751 chr2:209063 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.42 8.39 0.31 3.21e-16 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg08219700 chr8:58056026 NA 0.45 8.38 0.31 3.42e-16 Developmental language disorder (linguistic errors); BRCA cis rs1018836 0.886 rs10956750 chr8:91621704 G/C cg16814680 chr8:91681699 NA -0.6 -12.87 -0.45 7.48e-34 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.34e-24 Motion sickness; BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg08470875 chr2:26401718 FAM59B -0.47 -7.9 -0.3 1.25e-14 Gut microbiome composition (summer); BRCA cis rs10464366 0.746 rs34792397 chr7:39146331 G/A cg15212455 chr7:39170539 POU6F2 0.38 8.67 0.32 3.62e-17 IgG glycosylation; BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg27170947 chr2:26402098 FAM59B -0.81 -13.07 -0.46 9.42e-35 Gut microbiome composition (summer); BRCA cis rs7267979 1.000 rs6050631 chr20:25431749 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.9 0.33 5.62e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9394841 0.692 rs9381095 chr6:41806708 T/A cg08135965 chr6:41755394 TOMM6 0.47 7.82 0.3 2.15e-14 Mean corpuscular hemoglobin;Red cell distribution width; BRCA trans rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.36 -8.06 -0.3 3.8e-15 Endometrial cancer; BRCA cis rs853679 0.517 rs9368550 chr6:28051803 T/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg05025164 chr4:1340916 KIAA1530 0.6 12.24 0.44 4.16e-31 Longevity; BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg01262667 chr19:19385393 TM6SF2 0.4 10.38 0.38 1.92e-23 Tonsillectomy; BRCA trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs7631605 0.905 rs7651033 chr3:37116042 A/G cg15934958 chr3:37212084 LRRFIP2 -0.45 -10.47 -0.38 8.68e-24 Cerebrospinal P-tau181p levels; BRCA cis rs6866344 0.697 rs62392831 chr5:178134365 A/G cg10224037 chr5:178157518 ZNF354A 0.76 16.24 0.54 6.3e-50 Neutrophil percentage of white cells; BRCA trans rs79976124 0.879 rs77185357 chr6:66629070 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 10.6 0.39 2.8e-24 Type 2 diabetes; BRCA cis rs12541635 0.966 rs6469031 chr8:107048095 T/C cg10147462 chr8:107024639 NA 0.37 9.62 0.36 1.52e-20 Age of smoking initiation; BRCA cis rs8017423 1.000 rs8017423 chr14:90679910 A/G cg04374321 chr14:90722782 PSMC1 0.73 19.16 0.6 5.44e-65 Mortality in heart failure; BRCA cis rs7766436 0.885 rs13210010 chr6:22585075 C/T cg13666174 chr6:22585274 NA -0.49 -11.63 -0.42 1.65e-28 Coronary artery disease; BRCA cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.51 0.38 6.22e-24 Bipolar disorder; BRCA cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg10978503 chr1:24200527 CNR2 -0.45 -10.3 -0.38 3.98e-23 Immature fraction of reticulocytes; BRCA trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg22491629 chr6:157744540 C6orf35 -0.65 -11.65 -0.42 1.44e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11578532 chr1:161008127 TSTD1 0.25 7.97 0.3 7.38e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs9914988 0.887 rs12947735 chr17:27156866 A/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.88 -0.33 6.75e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs17401966 0.838 rs61775887 chr1:10284733 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.65 0.48 2.12e-37 Hepatocellular carcinoma; BRCA cis rs12477438 0.798 rs9308816 chr2:99637230 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.89 -0.58 2.44e-58 Chronic sinus infection; BRCA cis rs9880211 0.948 rs9820621 chr3:136110513 G/A cg21827317 chr3:136751795 NA -0.46 -8.04 -0.3 4.51e-15 Body mass index;Height; BRCA cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg20908204 chr19:46285434 DMPK 0.27 8.02 0.3 4.92e-15 Coronary artery disease; BRCA cis rs2070488 0.775 rs13072731 chr3:38533335 A/C cg24069376 chr3:38537580 EXOG 0.34 9.45 0.35 6.48e-20 Electrocardiographic conduction measures; BRCA cis rs4363385 0.510 rs12083211 chr1:153032131 A/T cg25856811 chr1:152973957 SPRR3 0.32 8.01 0.3 5.35e-15 Inflammatory skin disease; BRCA cis rs208520 1.000 rs208527 chr6:66957209 A/C cg07460842 chr6:66804631 NA -0.86 -14.32 -0.49 1.47e-40 Exhaled nitric oxide output; BRCA cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.74 10.05 0.37 3.71e-22 Initial pursuit acceleration; BRCA cis rs2835872 0.758 rs1787399 chr21:39037883 A/G cg06728970 chr21:39037746 KCNJ6 0.45 12.77 0.45 2.03e-33 Electroencephalographic traits in alcoholism; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.92 -0.45 4.51e-34 Lymphocyte counts; BRCA cis rs76419734 0.510 rs2553446 chr4:106696476 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.43 -9.34 -0.35 1.56e-19 Post bronchodilator FEV1; BRCA cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg09184832 chr6:79620586 NA -0.43 -8.43 -0.32 2.29e-16 Intelligence (multi-trait analysis); BRCA cis rs7809950 1.000 rs4727681 chr7:107096144 T/C cg23024343 chr7:107201750 COG5 -0.41 -9.44 -0.35 6.8e-20 Coronary artery disease; BRCA cis rs2243480 1.000 rs2462569 chr7:65474846 C/T cg18252515 chr7:66147081 NA 0.8 11.78 0.42 3.85e-29 Diabetic kidney disease; BRCA cis rs7481584 0.624 rs438384 chr11:3045651 A/G cg08508325 chr11:3079039 CARS 0.26 7.88 0.3 1.39e-14 Calcium levels; BRCA cis rs4474465 1.000 rs10899514 chr11:78172695 A/G cg27205649 chr11:78285834 NARS2 -0.29 -8.82 -0.33 1.12e-17 Alzheimer's disease (survival time); BRCA cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg18904891 chr8:8559673 CLDN23 -0.65 -13.52 -0.47 8.42e-37 Obesity-related traits; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg13047869 chr3:10149882 C3orf24 0.53 11.24 0.41 6.83e-27 Alzheimer's disease; BRCA cis rs1003719 0.742 rs8129231 chr21:38501034 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.24 -0.49 3.73e-40 Eye color traits; BRCA cis rs78456975 0.739 rs28913003 chr2:1519620 A/T cg12573674 chr2:1569213 NA -0.48 -9.48 -0.35 4.9e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7772486 0.817 rs2748491 chr6:146327759 T/C cg23711669 chr6:146136114 FBXO30 0.68 15.41 0.52 8.51e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.43 -0.44 6.2e-32 Chronic sinus infection; BRCA cis rs4642101 0.618 rs9877079 chr3:12821287 A/G cg24848339 chr3:12840334 CAND2 0.49 13.19 0.46 2.72e-35 QRS complex (12-leadsum); BRCA cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 10.2 0.37 1.01e-22 Aortic root size; BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg11814155 chr7:99998594 ZCWPW1 -0.45 -8.08 -0.3 3.2e-15 Platelet count; BRCA cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg22903471 chr2:27725779 GCKR -0.34 -8.22 -0.31 1.15e-15 Total body bone mineral density; BRCA cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg05283184 chr6:79620031 NA -0.44 -11.15 -0.4 1.62e-26 Intelligence (multi-trait analysis); BRCA cis rs12911832 1.000 rs12911832 chr15:58985904 A/T cg05156742 chr15:59063176 FAM63B 0.49 9.79 0.36 3.51e-21 Schizophrenia; BRCA cis rs8010715 1.000 rs8010715 chr14:24609147 T/C cg23112188 chr14:24563095 PCK2 -0.36 -8.83 -0.33 1e-17 IgG glycosylation; BRCA cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg11161846 chr1:160990452 F11R -0.45 -11.04 -0.4 4.71e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs10876993 0.928 rs2640629 chr12:58065448 C/T cg18357645 chr12:58087776 OS9 0.48 14.32 0.49 1.46e-40 Celiac disease or Rheumatoid arthritis; BRCA cis rs11711311 1.000 rs13061150 chr3:113506734 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.86 -0.39 2.44e-25 IgG glycosylation; BRCA cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg11366901 chr6:160182831 ACAT2 0.69 13.55 0.47 5.73e-37 Age-related macular degeneration (geographic atrophy); BRCA cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 17.83 0.58 4.99e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9399137 0.507 rs12663810 chr6:135289782 G/C cg22676075 chr6:135203613 NA 0.45 8.74 0.33 2.05e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7666738 0.830 rs1426663 chr4:98990092 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.25e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs10992471 0.528 rs10761158 chr9:95205322 T/G cg14631576 chr9:95140430 CENPP -0.35 -8.63 -0.32 4.75e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7766436 0.727 rs2066339 chr6:22610612 T/C cg13666174 chr6:22585274 NA -0.36 -9.25 -0.34 3.33e-19 Coronary artery disease; BRCA cis rs7618501 0.602 rs2071206 chr3:50160109 G/A cg24110177 chr3:50126178 RBM5 0.41 11.35 0.41 2.5e-27 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg24531977 chr5:56204891 C5orf35 -0.71 -15.57 -0.52 1.41e-46 Initial pursuit acceleration; BRCA cis rs713587 0.563 rs2033655 chr2:25101092 C/T cg04586622 chr2:25135609 ADCY3 0.44 11.62 0.42 1.83e-28 Body mass index in non-asthmatics; BRCA cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg24692254 chr21:30365293 RNF160 -0.48 -10.44 -0.38 1.2e-23 Pancreatic cancer; BRCA cis rs7647973 0.560 rs77473999 chr3:49777660 T/C cg03060546 chr3:49711283 APEH -0.56 -8.51 -0.32 1.27e-16 Menarche (age at onset); BRCA cis rs4561483 0.624 rs2215928 chr16:11927918 A/T cg08843971 chr16:11963173 GSPT1 -0.41 -8.86 -0.33 7.61e-18 Testicular germ cell tumor; BRCA cis rs10782582 0.593 rs11163915 chr1:76130199 C/T cg03433033 chr1:76189801 ACADM -0.47 -9.87 -0.36 1.74e-21 Daytime sleep phenotypes; BRCA cis rs1997103 0.911 rs6945663 chr7:55407011 C/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9831754 0.704 rs9882111 chr3:78470746 A/G cg06138941 chr3:78371609 NA -0.61 -12.92 -0.46 4.17e-34 Calcium levels; BRCA cis rs593982 0.920 rs563427 chr11:65484569 A/G cg08755490 chr11:65554678 OVOL1 1.18 17.25 0.56 4.81e-55 Atopic dermatitis; BRCA trans rs1005277 0.579 rs1780146 chr10:38517874 C/A cg23533926 chr12:111358616 MYL2 -0.42 -8.72 -0.33 2.32e-17 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg00166722 chr3:10149974 C3orf24 0.64 12.62 0.45 9.76e-33 Alzheimer's disease; BRCA cis rs933688 1.000 rs10041402 chr5:90738948 A/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.8 17.42 0.57 6.31e-56 Smoking behavior; BRCA cis rs11190604 1.000 rs2295770 chr10:102239829 G/A cg07080220 chr10:102295463 HIF1AN 0.51 11.37 0.41 2.17e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7085104 0.632 rs4290163 chr10:104610926 G/T cg04362960 chr10:104952993 NT5C2 0.37 8.76 0.33 1.69e-17 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs738322 0.804 rs4821743 chr22:38514906 A/G cg20207973 chr22:38506712 BAIAP2L2 0.39 9.82 0.36 2.79e-21 Cutaneous nevi; BRCA cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg01262667 chr19:19385393 TM6SF2 0.42 10.88 0.4 2.08e-25 Tonsillectomy; BRCA cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.52 -9.94 -0.37 9.72e-22 Response to bleomycin (chromatid breaks); BRCA cis rs17095355 0.901 rs12572168 chr10:111764786 A/C cg00817464 chr10:111662876 XPNPEP1 -0.47 -10.41 -0.38 1.53e-23 Biliary atresia; BRCA cis rs2279817 1.000 rs1339801 chr1:18020298 A/G cg21791023 chr1:18019539 ARHGEF10L 0.54 16.21 0.54 8.9e-50 Neuroticism; BRCA cis rs644799 0.648 rs1016031 chr11:95473365 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.55 -12.19 -0.43 6.82e-31 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs8028182 0.636 rs7163907 chr15:75845097 T/C cg20655648 chr15:75932815 IMP3 0.43 8.3 0.31 5.99e-16 Sudden cardiac arrest; BRCA cis rs8072100 0.817 rs6505049 chr17:45675781 G/A cg08085267 chr17:45401833 C17orf57 0.61 12.47 0.44 4.32e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs7647973 0.593 rs55997059 chr3:49858661 A/T cg21659725 chr3:3221576 CRBN 0.52 9.83 0.36 2.53e-21 Menarche (age at onset); BRCA cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg14349672 chr11:133703707 NA 0.41 9.19 0.34 5.49e-19 Childhood ear infection; BRCA cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg11764359 chr7:65958608 NA 0.67 14.83 0.51 5.66e-43 Aortic root size; BRCA cis rs7412746 0.658 rs12090215 chr1:150893660 C/A cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.26e-14 Melanoma; BRCA cis rs7617773 0.780 rs13079728 chr3:48339360 A/G cg11946769 chr3:48343235 NME6 0.69 14.08 0.49 2.16e-39 Coronary artery disease; BRCA cis rs12200560 0.505 rs9400166 chr6:97077101 G/A cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg01304814 chr3:48885189 PRKAR2A 0.57 7.91 0.3 1.11e-14 Cognitive function; BRCA cis rs7607369 0.559 rs13002060 chr2:219660394 G/T cg02176678 chr2:219576539 TTLL4 -0.39 -10.35 -0.38 2.52e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg27286337 chr10:134555280 INPP5A 0.65 11.42 0.41 1.26e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg16049864 chr8:95962084 TP53INP1 0.44 10.67 0.39 1.39e-24 Type 2 diabetes; BRCA cis rs3772130 0.962 rs9839617 chr3:121516577 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.79 0.39 4.91e-25 Cognitive performance; BRCA cis rs7577696 0.554 rs34835885 chr2:32325414 G/A cg02381751 chr2:32503542 YIPF4 -0.48 -8.82 -0.33 1.1e-17 Inflammatory biomarkers; BRCA cis rs4679121 0.642 rs76826102 chr3:126185964 C/T cg05485589 chr3:126194908 ZXDC -0.76 -8.2 -0.31 1.32e-15 Pursuit maintenance gain; BRCA cis rs6745190 0.512 rs13026070 chr2:181991422 C/A cg00481216 chr2:181971175 NA 0.47 8.91 0.33 5.29e-18 White blood cell count; BRCA cis rs9814567 0.964 rs9847788 chr3:134186496 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -8.94 -0.33 4.17e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.31 0.38 3.74e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2882667 0.756 rs11957953 chr5:138479377 G/T cg04439458 chr5:138467593 SIL1 -0.46 -11.44 -0.41 1.02e-27 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg05347473 chr6:146136440 FBXO30 0.4 7.86 0.3 1.68e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg18132916 chr6:79620363 NA -0.48 -10.91 -0.4 1.59e-25 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.534 rs10506120 chr12:34235603 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.35 0.49 1.15e-40 Morning vs. evening chronotype; BRCA trans rs4650994 0.544 rs2476560 chr1:178594919 A/G cg05059571 chr16:84539110 KIAA1609 0.57 12.4 0.44 8.57e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7927771 0.542 rs7108479 chr11:47781460 G/T cg20307385 chr11:47447363 PSMC3 0.42 9.52 0.35 3.43e-20 Subjective well-being; BRCA cis rs7264396 0.790 rs2425115 chr20:34322418 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.14 0.31 2.05e-15 Total cholesterol levels; BRCA cis rs514406 0.729 rs534070 chr1:53308858 T/G cg16325326 chr1:53192061 ZYG11B 0.57 12.74 0.45 2.7e-33 Monocyte count; BRCA cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg11663144 chr21:46675770 NA -0.49 -9.84 -0.36 2.33e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13315871 0.790 rs13071148 chr3:58310838 A/C cg20936604 chr3:58311152 NA -0.64 -8.25 -0.31 9.38e-16 Cholesterol, total; BRCA cis rs7809950 0.678 rs2237665 chr7:106906998 T/C cg23024343 chr7:107201750 COG5 -0.46 -9.05 -0.34 1.67e-18 Coronary artery disease; BRCA cis rs11718455 0.920 rs34909426 chr3:44000472 G/A cg08738300 chr3:44038990 NA 0.44 8.56 0.32 8.69e-17 Coronary artery disease; BRCA cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg04455712 chr21:45112962 RRP1B 0.4 10.47 0.38 9.08e-24 Mean corpuscular volume; BRCA trans rs7829975 0.688 rs7837587 chr8:8378992 T/C cg21775007 chr8:11205619 TDH 0.43 8.77 0.33 1.56e-17 Mood instability; BRCA cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs265548 0.646 rs36689 chr19:17910639 A/G cg04517722 chr19:17905589 B3GNT3 0.42 8.33 0.31 4.98e-16 Tumor biomarkers; BRCA cis rs921968 0.544 rs58827325 chr2:219415166 A/T cg10223061 chr2:219282414 VIL1 -0.28 -8.19 -0.31 1.43e-15 Mean corpuscular hemoglobin concentration; BRCA trans rs8073060 0.586 rs8077826 chr17:34001139 G/A cg19694781 chr19:47549865 TMEM160 -1.04 -21.53 -0.65 9.91e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.51 0.61 7.34e-67 Smoking behavior; BRCA cis rs7246657 0.882 rs28623164 chr19:37913453 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA cis rs2370759 1.000 rs2769241 chr10:32556229 T/C cg18270830 chr10:32634957 EPC1 -0.5 -8.81 -0.33 1.21e-17 Sexual dysfunction (female); BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg22638593 chr5:131593259 PDLIM4 0.35 8.86 0.33 7.84e-18 Acylcarnitine levels; BRCA trans rs11098499 0.954 rs1022145 chr4:120230979 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.13 0.31 2.19e-15 Corneal astigmatism; BRCA trans rs9944715 0.954 rs4890319 chr18:43812644 T/A cg01718231 chr17:29326311 RNF135 -0.46 -9.07 -0.34 1.5e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs919433 0.680 rs2564383 chr2:198310862 A/G cg00792783 chr2:198669748 PLCL1 0.39 8.77 0.33 1.56e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1865760 0.566 rs9295686 chr6:26081983 G/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs1882538 0.551 rs6974618 chr7:133084031 C/A cg10665199 chr7:133106180 EXOC4 0.43 9.35 0.35 1.49e-19 Intelligence (multi-trait analysis); BRCA cis rs2880765 0.566 rs17553249 chr15:86006694 A/G cg19183879 chr15:85880815 NA -0.32 -7.81 -0.3 2.3e-14 Coronary artery disease; BRCA cis rs10197940 0.578 rs2432946 chr2:152306897 G/T cg19508488 chr2:152266495 RIF1 -0.38 -8.25 -0.31 8.94e-16 Lung cancer; BRCA cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg23711669 chr6:146136114 FBXO30 -0.71 -16.77 -0.55 1.44e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.5 -0.59 1.6e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg03146154 chr1:46216737 IPP 0.54 12.03 0.43 3.34e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6977660 0.714 rs10252597 chr7:19791171 G/T cg05791153 chr7:19748676 TWISTNB -0.66 -11.76 -0.42 4.99e-29 Thyroid stimulating hormone; BRCA cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg00677455 chr12:58241039 CTDSP2 0.73 17.73 0.57 1.61e-57 Multiple sclerosis; BRCA cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg17063962 chr7:91808500 NA 0.53 12.4 0.44 8.6e-32 Breast cancer; BRCA cis rs992157 0.835 rs2271543 chr2:219142491 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.35 -0.41 2.59e-27 Colorectal cancer; BRCA cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.64 -0.45 7.89e-33 Bipolar disorder; BRCA cis rs12477438 0.765 rs9710648 chr2:99673129 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA trans rs4718428 0.705 rs4717328 chr7:66352665 T/C cg18876405 chr7:65276391 NA 0.43 8.39 0.32 3.04e-16 Corneal structure; BRCA cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.55 10.54 0.38 4.59e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05901451 chr6:126070800 HEY2 -0.44 -10.83 -0.39 3.18e-25 Migraine; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg03188948 chr7:1209495 NA 0.49 10.09 0.37 2.69e-22 Longevity;Endometriosis; BRCA cis rs7766436 0.848 rs11759474 chr6:22580980 G/T cg13666174 chr6:22585274 NA -0.43 -9.27 -0.34 2.82e-19 Coronary artery disease; BRCA cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg14440974 chr22:39074834 NA 0.39 9.2 0.34 5.18e-19 Menopause (age at onset); BRCA cis rs838147 0.537 rs503279 chr19:49209010 C/T cg07051648 chr19:49177693 NTN5;SEC1 0.42 7.96 0.3 8.03e-15 Dietary macronutrient intake; BRCA cis rs10744422 0.800 rs2343110 chr12:123343571 T/G cg25930673 chr12:123319894 HIP1R -0.53 -8.19 -0.31 1.41e-15 Schizophrenia; BRCA cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg17366294 chr4:99064904 C4orf37 0.43 10.0 0.37 5.7e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.569 rs11135394 chr5:93187135 C/T cg25358565 chr5:93447407 FAM172A -0.48 -8.62 -0.32 5.37e-17 Diabetic retinopathy; BRCA cis rs2016266 1.000 rs2016266 chr12:53727955 A/G cg26875137 chr12:53738046 NA -0.38 -10.05 -0.37 3.54e-22 Bone mineral density (spine);Bone mineral density; BRCA cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg19539972 chr4:7069911 GRPEL1 -0.63 -12.31 -0.44 2.18e-31 Monocyte percentage of white cells; BRCA cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg08885076 chr2:99613938 TSGA10 0.44 10.37 0.38 2.09e-23 Chronic sinus infection; BRCA cis rs611744 0.625 rs11991891 chr8:109294858 G/A cg21045802 chr8:109455806 TTC35 0.39 9.09 0.34 1.27e-18 Dupuytren's disease; BRCA cis rs9467773 1.000 rs6930120 chr6:26555484 A/G cg11502198 chr6:26597334 ABT1 0.48 9.62 0.36 1.45e-20 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.88e-15 Breast cancer; BRCA cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg15017067 chr4:17643749 FAM184B 0.32 9.82 0.36 2.75e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs425277 0.916 rs414777 chr1:2101687 G/A cg00981070 chr1:2046702 PRKCZ 0.31 8.21 0.31 1.24e-15 Height; BRCA cis rs798554 0.610 rs2644304 chr7:2878779 T/C cg13628971 chr7:2884303 GNA12 0.42 9.32 0.35 1.81e-19 Height; BRCA cis rs73001065 0.636 rs73002960 chr19:19582992 C/T cg03709012 chr19:19516395 GATAD2A 1.02 14.02 0.49 3.86e-39 LDL cholesterol; BRCA cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg02297831 chr4:17616191 MED28 -0.35 -8.17 -0.31 1.61e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg24069376 chr3:38537580 EXOG -0.31 -8.96 -0.33 3.44e-18 Electrocardiographic conduction measures; BRCA cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg20908204 chr19:46285434 DMPK -0.28 -8.31 -0.31 5.57e-16 Coronary artery disease; BRCA cis rs12612619 0.579 rs6753540 chr2:27080134 G/A cg12368169 chr2:27073192 DPYSL5 -0.34 -10.19 -0.37 1.1e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs514406 0.679 rs541852 chr1:53256834 A/G cg01802117 chr1:53393560 SCP2 0.41 8.55 0.32 8.96e-17 Monocyte count; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg12016809 chr21:47604291 C21orf56 -0.39 -7.83 -0.3 2.11e-14 Testicular germ cell tumor; BRCA cis rs11105298 0.891 rs10777162 chr12:89830523 A/G cg00757033 chr12:89920650 WDR51B 0.48 9.83 0.36 2.59e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs919433 0.679 rs6757669 chr2:198530355 C/T cg00792783 chr2:198669748 PLCL1 0.39 9.01 0.34 2.27e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.71 0.42 7.58e-29 Personality dimensions; BRCA trans rs3808502 0.527 rs4410870 chr8:11156120 C/G cg06636001 chr8:8085503 FLJ10661 -0.45 -8.58 -0.32 7e-17 Neuroticism; BRCA cis rs7520050 0.897 rs4440807 chr1:46470878 T/C cg24296786 chr1:45957014 TESK2 0.44 9.84 0.36 2.31e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7715806 0.500 rs2307115 chr5:74990348 T/C cg19683494 chr5:74908142 NA 0.53 8.53 0.32 1.07e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg27478167 chr7:817139 HEATR2 0.53 10.5 0.38 6.57e-24 Cerebrospinal P-tau181p levels; BRCA trans rs7824557 0.591 rs2572452 chr8:11228254 C/T cg06636001 chr8:8085503 FLJ10661 -0.43 -8.79 -0.33 1.42e-17 Retinal vascular caliber; BRCA cis rs2635047 0.967 rs2576056 chr18:44675462 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.4 8.62 0.32 5.07e-17 Educational attainment; BRCA cis rs7677751 0.767 rs7676985 chr4:55064573 G/A cg17187183 chr4:55093834 PDGFRA 0.4 7.99 0.3 6.28e-15 Corneal astigmatism; BRCA cis rs6686889 1 rs6686889 chr1:25030470 C/T cg01905478 chr1:25040257 NA 0.39 9.01 0.34 2.37e-18 Diastolic blood pressure; BRCA trans rs9858542 0.953 rs67216675 chr3:49493151 G/T cg21659725 chr3:3221576 CRBN -0.47 -9.99 -0.37 6.33e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6570726 0.935 rs386823 chr6:145841365 C/T cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs829883 0.659 rs10860342 chr12:98941223 C/T cg25150519 chr12:98850993 NA 0.5 9.04 0.34 1.78e-18 Colorectal adenoma (advanced); BRCA cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg03517284 chr6:25882590 NA -0.51 -11.54 -0.42 4.09e-28 Blood metabolite levels; BRCA cis rs965469 0.779 rs6037544 chr20:3290570 A/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.62 -0.32 5.47e-17 IFN-related cytopenia; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.66 12.12 0.43 1.36e-30 Alzheimer's disease; BRCA cis rs992157 0.643 rs10191283 chr2:219056755 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.51 11.29 0.41 4.25e-27 Colorectal cancer; BRCA trans rs3749237 0.964 rs11717463 chr3:49808981 C/T cg21659725 chr3:3221576 CRBN 0.49 10.92 0.4 1.46e-25 Resting heart rate; BRCA cis rs7267979 1.000 rs1888999 chr20:25291848 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.3 7.98 0.3 6.96e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6854137 0.904 rs13124822 chr4:169737712 G/A cg20607169 chr4:169750834 PALLD 0.35 8.03 0.3 4.66e-15 Vein graft stenosis in coronary artery bypass grafting; BRCA cis rs4819052 0.851 rs2838866 chr21:46713014 G/C cg11663144 chr21:46675770 NA -0.56 -12.64 -0.45 7.62e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg14863265 chr7:2801509 GNA12 -0.42 -9.68 -0.36 8.81e-21 Height; BRCA cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.52 -11.26 -0.41 5.99e-27 IgG glycosylation; BRCA cis rs1401999 1.000 rs4148579 chr3:183685249 T/C cg01324343 chr3:183735012 ABCC5 0.83 20.62 0.63 8.06e-73 Anterior chamber depth; BRCA cis rs4363385 0.818 rs572821 chr1:153008276 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg10729496 chr3:10149963 C3orf24 0.48 8.98 0.33 3e-18 Alzheimer's disease; BRCA cis rs36051895 0.659 rs58345215 chr9:5043767 A/T cg02405213 chr9:5042618 JAK2 -0.51 -9.12 -0.34 9.89e-19 Pediatric autoimmune diseases; BRCA cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg15017067 chr4:17643749 FAM184B 0.34 10.54 0.38 4.58e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg04944784 chr2:26401820 FAM59B -0.69 -11.34 -0.41 2.76e-27 Gut microbiome composition (summer); BRCA cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg11764359 chr7:65958608 NA -0.77 -17.98 -0.58 8.38e-59 Aortic root size; BRCA cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg23750338 chr8:142222470 SLC45A4 0.4 9.72 0.36 6.16e-21 Immature fraction of reticulocytes; BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg12444411 chr7:2802554 GNA12 -0.35 -8.82 -0.33 1.07e-17 Height; BRCA trans rs877282 1.000 rs11253362 chr10:770979 G/T cg22713356 chr15:30763199 NA 1.38 27.92 0.74 9.42e-113 Uric acid levels; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg10862848 chr6:42927986 GNMT -0.35 -14.85 -0.51 4.73e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.96 0.33 3.58e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6964587 0.610 rs10953056 chr7:91466700 C/T cg17063962 chr7:91808500 NA 0.54 12.39 0.44 9.73e-32 Breast cancer; BRCA cis rs7493 0.901 rs11764079 chr7:95026229 A/G cg19678392 chr7:94953810 PON1 0.4 8.22 0.31 1.15e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs3849570 1.000 rs2290081 chr3:81810725 C/T cg07356753 chr3:81810745 GBE1 -0.47 -11.41 -0.41 1.37e-27 Waist circumference;Body mass index; BRCA cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -10.98 -0.4 7.88e-26 IgG glycosylation; BRCA cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg04756594 chr16:24857601 SLC5A11 0.48 10.08 0.37 2.94e-22 Intelligence (multi-trait analysis); BRCA cis rs7607369 0.559 rs4674342 chr2:219660064 T/C cg02176678 chr2:219576539 TTLL4 -0.39 -10.33 -0.38 3.04e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs4664304 0.620 rs3951216 chr2:160711045 G/C cg14819504 chr2:160761413 LY75 0.32 7.94 0.3 9.35e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs68170813 0.559 rs6949961 chr7:106850755 G/T cg02696742 chr7:106810147 HBP1 0.5 8.22 0.31 1.12e-15 Coronary artery disease; BRCA cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg07636037 chr3:49044803 WDR6 0.97 28.85 0.75 8.29e-118 Parkinson's disease; BRCA cis rs7914558 1.000 rs4917994 chr10:104811699 C/T cg04362960 chr10:104952993 NT5C2 0.43 10.39 0.38 1.88e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6500602 1.000 rs6500602 chr16:4497451 T/C cg08645402 chr16:4508243 NA 0.4 9.06 0.34 1.52e-18 Schizophrenia; BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.62 0.42 1.95e-28 Tonsillectomy; BRCA cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg03709012 chr19:19516395 GATAD2A 0.73 16.16 0.54 1.74e-49 Tonsillectomy; BRCA cis rs9814567 0.806 rs7648616 chr3:134318074 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17376456 0.825 rs17372725 chr5:93135588 C/A cg25358565 chr5:93447407 FAM172A 1.15 18.07 0.58 2.94e-59 Diabetic retinopathy; BRCA cis rs7944584 0.545 rs7118178 chr11:47659135 G/A cg03711944 chr11:47377212 SPI1 -0.44 -10.23 -0.38 7.49e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs12464559 0.522 rs7583148 chr2:152620986 C/T cg01189475 chr2:152685088 ARL5A 0.61 9.3 0.35 2.12e-19 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg13628971 chr7:2884303 GNA12 -0.59 -12.88 -0.45 6.2e-34 Height; BRCA cis rs12545109 0.837 rs6474063 chr8:57355545 C/T cg09654669 chr8:57350985 NA -0.42 -7.95 -0.3 8.65e-15 Obesity-related traits; BRCA cis rs2795502 1.000 rs3121323 chr10:43377166 A/G cg20628663 chr10:43360327 NA -0.67 -13.25 -0.46 1.39e-35 Blood protein levels; BRCA trans rs2204008 0.627 rs10878486 chr12:38148601 T/G cg06521331 chr12:34319734 NA -0.54 -9.6 -0.36 1.77e-20 Bladder cancer; BRCA trans rs7746199 0.736 rs34105070 chr6:27560805 C/T cg06606381 chr12:133084897 FBRSL1 -0.87 -8.53 -0.32 1.1e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2624839 0.704 rs2526384 chr3:50181136 C/T cg05623727 chr3:50126028 RBM5 0.44 9.09 0.34 1.24e-18 Intelligence (multi-trait analysis); BRCA cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg08807101 chr21:30365312 RNF160 -0.61 -15.64 -0.53 6.71e-47 Dental caries; BRCA cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg10802521 chr3:52805072 NEK4 -0.33 -8.97 -0.33 3.32e-18 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.865 rs11722183 chr4:120280597 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.13 0.31 2.24e-15 Corneal astigmatism; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.69 14.53 0.5 1.52e-41 Lymphocyte counts; BRCA trans rs11098499 0.954 rs12506546 chr4:120301618 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.82 -0.3 2.11e-14 Corneal astigmatism; BRCA cis rs897984 0.762 rs8062719 chr16:31002664 A/G cg02466173 chr16:30829666 NA 0.45 9.79 0.36 3.64e-21 Dementia with Lewy bodies; BRCA cis rs11758351 1.000 rs77961951 chr6:26186075 A/G cg01420254 chr6:26195488 NA 0.57 7.89 0.3 1.3e-14 Gout;Renal underexcretion gout; BRCA cis rs10465746 0.967 rs11163868 chr1:84397013 T/G cg10977910 chr1:84465055 TTLL7 0.49 9.8 0.36 3.11e-21 Obesity-related traits; BRCA cis rs6750047 0.868 rs1431332 chr2:38280253 G/A cg07380506 chr2:38303506 CYP1B1 0.43 9.91 0.37 1.21e-21 Cutaneous malignant melanoma;Melanoma; BRCA cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.27 0.44 3.21e-31 Mean platelet volume; BRCA cis rs6450176 0.638 rs16881969 chr5:53300748 A/G ch.5.1024479R chr5:53302184 ARL15 0.83 16.54 0.55 2.07e-51 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs4808199 0.948 rs2301671 chr19:19466269 C/T cg01262667 chr19:19385393 TM6SF2 0.38 8.18 0.31 1.52e-15 Nonalcoholic fatty liver disease; BRCA cis rs7959452 0.901 rs1384 chr12:69747834 C/T cg20891283 chr12:69753455 YEATS4 0.56 13.76 0.48 6.62e-38 Blood protein levels; BRCA cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg19717773 chr7:2847554 GNA12 -0.41 -8.94 -0.33 4.11e-18 Height; BRCA cis rs1003719 0.725 rs2187101 chr21:38452379 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.25e-40 Eye color traits; BRCA cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg22875332 chr1:76189707 ACADM 0.66 11.96 0.43 6.74e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg13944838 chr5:179740914 GFPT2 -0.67 -13.97 -0.48 7.1e-39 Height; BRCA cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11644478 chr21:40555479 PSMG1 -0.65 -13.71 -0.48 1.04e-37 Cognitive function; BRCA cis rs7766436 0.614 rs16886454 chr6:22562975 T/A cg13666174 chr6:22585274 NA -0.41 -8.63 -0.32 4.72e-17 Coronary artery disease; BRCA cis rs36051895 0.589 rs7874785 chr9:5196695 C/T cg02405213 chr9:5042618 JAK2 0.46 8.79 0.33 1.36e-17 Pediatric autoimmune diseases; BRCA cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg27572855 chr1:25598939 RHD 0.48 13.54 0.47 6.98e-37 Erythrocyte sedimentation rate; BRCA cis rs875971 0.790 rs10257911 chr7:65743770 A/G cg18876405 chr7:65276391 NA -0.51 -11.48 -0.41 7.06e-28 Aortic root size; BRCA cis rs4332037 0.624 rs11764337 chr7:1892309 A/G cg23422044 chr7:1970798 MAD1L1 0.59 10.99 0.4 7.7e-26 Bipolar disorder; BRCA cis rs6763687 0.637 rs937511 chr3:171816001 A/C cg16233210 chr3:171778391 FNDC3B 0.4 9.34 0.35 1.53e-19 Red cell distribution width; BRCA cis rs6542838 0.641 rs4553869 chr2:99505940 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.06 -0.34 1.58e-18 Fear of minor pain; BRCA cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg02466173 chr16:30829666 NA 0.49 11.12 0.4 2.31e-26 Dementia with Lewy bodies; BRCA trans rs9325144 0.647 rs35254764 chr12:39102928 T/C cg23762105 chr12:34175262 ALG10 0.35 7.86 0.3 1.66e-14 Morning vs. evening chronotype; BRCA cis rs9473147 0.516 rs7749271 chr6:47485002 T/C cg12968598 chr6:47444699 CD2AP 0.43 9.53 0.35 3.18e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Smoking initiation; BRCA cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg02659138 chr7:134003124 SLC35B4 0.34 10.65 0.39 1.74e-24 Mean platelet volume; BRCA cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.965 rs2305155 chr2:61729258 A/G cg15711740 chr2:61764176 XPO1 -0.55 -14.04 -0.49 3.23e-39 Tuberculosis; BRCA cis rs798554 0.655 rs798492 chr7:2799184 C/T cg09658497 chr7:2847517 GNA12 0.4 8.48 0.32 1.54e-16 Height; BRCA cis rs11583043 0.958 rs11583674 chr1:101396560 C/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.7 0.36 7.47e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.43e-20 Menopause (age at onset); BRCA cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.95e-23 Mean platelet volume; BRCA cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs9790314 0.905 rs1154701 chr3:161008025 T/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.28 -0.49 2.26e-40 Morning vs. evening chronotype; BRCA cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg08807101 chr21:30365312 RNF160 -0.44 -9.36 -0.35 1.36e-19 Dental caries; BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg08470875 chr2:26401718 FAM59B -0.51 -8.17 -0.31 1.62e-15 Gut microbiome composition (summer); BRCA cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg13010199 chr12:38710504 ALG10B 0.35 8.59 0.32 6.72e-17 Morning vs. evening chronotype; BRCA cis rs12540874 0.522 rs4947641 chr7:50489038 C/T cg18232548 chr7:50535776 DDC -0.49 -12.59 -0.45 1.25e-32 Systemic sclerosis; BRCA cis rs9463078 0.790 rs1324531 chr6:45136224 T/C cg25276700 chr6:44698697 NA -0.36 -8.17 -0.31 1.64e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7100689 0.646 rs6585967 chr10:82139791 A/G cg00277334 chr10:82204260 NA 0.4 8.06 0.3 3.86e-15 Post bronchodilator FEV1; BRCA cis rs7587476 1.000 rs1542173 chr2:215657560 C/T cg04004882 chr2:215674386 BARD1 -0.57 -10.47 -0.38 8.76e-24 Neuroblastoma; BRCA cis rs877529 0.683 rs139379 chr22:39525791 A/T cg12193277 chr22:39547181 CBX7 -0.4 -10.62 -0.39 2.18e-24 Multiple myeloma; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg00106254 chr7:1943704 MAD1L1 -0.45 -11.91 -0.43 1.17e-29 Bipolar disorder and schizophrenia; BRCA cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg11366901 chr6:160182831 ACAT2 0.68 13.59 0.47 3.9e-37 Age-related macular degeneration (geographic atrophy); BRCA cis rs870825 0.616 rs28620459 chr4:185627132 G/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.93e-19 Lymphocyte counts; BRCA cis rs939658 0.728 rs12904789 chr15:79412589 G/A cg17916960 chr15:79447300 NA -0.42 -9.82 -0.36 2.78e-21 Refractive error; BRCA cis rs9379945 1 rs9379945 chr6:26907831 T/C cg12826209 chr6:26865740 GUSBL1 0.69 9.88 0.36 1.63e-21 Intelligence (multi-trait analysis); BRCA cis rs7149337 0.836 rs35345236 chr14:51671817 T/C cg23942311 chr14:51606299 NA 0.42 12.01 0.43 4.05e-30 Cancer; BRCA cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.652 rs168751 chr5:148438264 C/T cg25326776 chr5:148520934 ABLIM3 -0.42 -7.81 -0.3 2.39e-14 Breast cancer; BRCA cis rs4363385 0.747 rs1611760 chr1:152957573 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.96e-16 Inflammatory skin disease; BRCA trans rs561341 1.000 rs550923 chr17:30327013 G/C cg20587970 chr11:113659929 NA -1.24 -22.67 -0.67 5.77e-84 Hip circumference adjusted for BMI; BRCA cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg09184832 chr6:79620586 NA -0.48 -10.52 -0.38 5.72e-24 Intelligence (multi-trait analysis); BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.23 0.31 1.06e-15 Tonsillectomy; BRCA cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg24675658 chr1:53192096 ZYG11B 0.66 14.44 0.5 3.96e-41 Monocyte count; BRCA cis rs7715811 1.000 rs10039621 chr5:13772457 C/T cg07548982 chr5:13769939 DNAH5 -0.36 -7.99 -0.3 6.33e-15 Subclinical atherosclerosis traits (other); BRCA cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.93 -0.3 9.9e-15 Bipolar disorder; BRCA cis rs243505 0.964 rs243509 chr7:148433634 G/A cg09806900 chr7:148480153 CUL1 -0.4 -8.36 -0.31 3.88e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.66 -0.32 3.85e-17 Developmental language disorder (linguistic errors); BRCA cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg26384229 chr12:38710491 ALG10B 0.66 14.29 0.49 2.01e-40 Morning vs. evening chronotype; BRCA cis rs27434 0.607 rs34753 chr5:96150911 C/T cg16492584 chr5:96139282 ERAP1 -0.5 -12.71 -0.45 3.7e-33 Ankylosing spondylitis; BRCA trans rs1997103 1.000 rs2877284 chr7:55408778 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4820539 0.966 rs5759600 chr22:23483769 C/A cg14186256 chr22:23484241 RTDR1 0.75 21.86 0.65 1.61e-79 Bone mineral density; BRCA cis rs12617721 0.718 rs1857746 chr2:99017358 A/G cg10123293 chr2:99228465 UNC50 0.49 8.94 0.33 4.21e-18 Bipolar disorder with mood-incongruent psychosis; BRCA trans rs1945213 0.694 rs7116741 chr11:55862620 C/T cg03929089 chr4:120376271 NA 0.61 10.56 0.39 3.97e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs7098414 0.511 rs7907575 chr10:82152675 T/G cg01528321 chr10:82214614 TSPAN14 0.67 14.16 0.49 9.13e-40 Post bronchodilator FEV1; BRCA cis rs798554 0.655 rs798492 chr7:2799184 C/T cg04166393 chr7:2884313 GNA12 -0.4 -8.66 -0.32 3.86e-17 Height; BRCA cis rs6700896 0.931 rs2889195 chr1:66156730 C/T cg04111102 chr1:66153794 NA 0.37 9.2 0.34 5e-19 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs372883 0.564 rs766928 chr21:30753606 A/G cg24692254 chr21:30365293 RNF160 0.45 10.13 0.37 1.87e-22 Pancreatic cancer; BRCA cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg16586182 chr3:47516702 SCAP 0.44 8.9 0.33 5.67e-18 Birth weight; BRCA cis rs13315871 0.929 rs11715290 chr3:58298413 C/T cg20936604 chr3:58311152 NA -0.65 -8.28 -0.31 7.46e-16 Cholesterol, total; BRCA cis rs6964587 0.967 rs10280620 chr7:91582183 C/G cg17063962 chr7:91808500 NA -0.52 -12.22 -0.44 5.29e-31 Breast cancer; BRCA cis rs16958440 1.000 rs60422392 chr18:44621473 T/C cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12667521 chr19:29218732 NA 0.41 8.17 0.31 1.6e-15 Methadone dose in opioid dependence; BRCA cis rs926392 0.572 rs6129156 chr20:37672209 A/C cg16355469 chr20:37678765 NA 0.46 10.43 0.38 1.28e-23 Dialysis-related mortality; BRCA cis rs4073582 0.595 rs801731 chr11:65938446 G/C cg16950941 chr11:66035639 RAB1B 0.44 12.29 0.44 2.53e-31 Gout; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00149659 chr3:10157352 C3orf10 -0.82 -14.34 -0.49 1.2e-40 Alzheimer's disease; BRCA cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg19729930 chr2:74357872 NA 0.65 14.34 0.49 1.3e-40 Gestational age at birth (maternal effect); BRCA cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg13628971 chr7:2884303 GNA12 0.39 8.78 0.33 1.55e-17 Height; BRCA cis rs10736390 1.000 rs11206402 chr1:55104317 G/C cg01517571 chr1:55089959 ACOT11;FAM151A -0.59 -14.18 -0.49 7.05e-40 Survival in pancreatic cancer; BRCA cis rs10484885 0.824 rs28372875 chr6:90529343 C/T cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.87 -0.36 1.7e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs78487399 0.908 rs74501107 chr2:43806012 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.97 -0.3 7.36e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs12368653 0.666 rs799265 chr12:58112189 A/G cg18357645 chr12:58087776 OS9 0.35 9.93 0.37 1e-21 Multiple sclerosis; BRCA cis rs701145 0.938 rs242117 chr3:154026467 T/C cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs11758351 0.660 rs56398712 chr6:26213868 A/G cg01420254 chr6:26195488 NA 0.55 8.56 0.32 8.23e-17 Gout;Renal underexcretion gout; BRCA cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg00677455 chr12:58241039 CTDSP2 -0.34 -7.87 -0.3 1.53e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg11266682 chr4:10021025 SLC2A9 0.38 10.09 0.37 2.66e-22 Bone mineral density; BRCA cis rs7903847 0.642 rs7092350 chr10:99140218 A/T cg20016023 chr10:99160130 RRP12 -0.26 -8.5 -0.32 1.35e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg05340658 chr4:99064831 C4orf37 0.61 14.11 0.49 1.47e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.730 rs12505735 chr4:120532956 G/T cg09307838 chr4:120376055 NA 0.66 13.33 0.47 6.13e-36 Corneal astigmatism; BRCA cis rs11190604 1.000 rs7099913 chr10:102314777 T/C cg07080220 chr10:102295463 HIF1AN 0.55 12.76 0.45 2.14e-33 Palmitoleic acid (16:1n-7) levels; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg10802521 chr3:52805072 NEK4 -0.29 -7.89 -0.3 1.27e-14 Bipolar disorder; BRCA trans rs35110281 0.641 rs4818858 chr21:45083097 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.42 -8.31 -0.31 5.77e-16 Mean corpuscular volume; BRCA cis rs2836974 0.897 rs3945 chr21:40566067 A/G cg11644478 chr21:40555479 PSMG1 0.76 15.66 0.53 4.79e-47 Cognitive function; BRCA cis rs9487051 0.872 rs9386794 chr6:109611521 A/C cg12927641 chr6:109611667 NA -0.42 -10.87 -0.39 2.35e-25 Reticulocyte fraction of red cells; BRCA cis rs1506636 1.000 rs644958 chr7:123400873 C/T cg03229431 chr7:123269106 ASB15 0.61 13.65 0.48 2.16e-37 Plateletcrit;Platelet count; BRCA cis rs7659604 0.702 rs6815790 chr4:122695385 A/C cg06713675 chr4:122721982 EXOSC9 -0.49 -11.74 -0.42 6.17e-29 Type 2 diabetes; BRCA cis rs4988958 0.584 rs7559845 chr2:103046214 T/G cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma (childhood onset); BRCA cis rs6426558 0.524 rs2813948 chr1:227459621 A/T cg10327440 chr1:227177885 CDC42BPA 0.48 9.58 0.35 2.09e-20 Neutrophil percentage of white cells; BRCA cis rs2204008 0.774 rs11520237 chr12:38266978 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.88e-18 Bladder cancer; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg04234412 chr22:24373322 LOC391322 -0.57 -14.17 -0.49 7.51e-40 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6430585 0.528 rs6743537 chr2:136702601 C/T cg07169764 chr2:136633963 MCM6 1.08 22.88 0.67 4.6e-85 Corneal structure; BRCA cis rs12618769 0.625 rs72819970 chr2:99034554 C/G cg10123293 chr2:99228465 UNC50 0.41 8.15 0.31 1.88e-15 Bipolar disorder; BRCA cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg18904891 chr8:8559673 CLDN23 0.66 13.31 0.47 7.14e-36 Obesity-related traits; BRCA cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg08045932 chr20:61659980 NA 0.5 11.21 0.41 9.54e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs6120849 0.754 rs6088682 chr20:33615702 A/C cg24642439 chr20:33292090 TP53INP2 0.6 10.29 0.38 4.57e-23 Protein C levels; BRCA cis rs8030485 0.756 rs1521624 chr15:79412399 C/A cg17916960 chr15:79447300 NA 0.35 8.23 0.31 1.09e-15 Left ventricle wall thickness; BRCA cis rs17253792 0.822 rs28549152 chr14:56091239 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs72781680 1.000 rs72781654 chr2:24218099 T/C cg08917208 chr2:24149416 ATAD2B 0.57 9.38 0.35 1.17e-19 Lymphocyte counts; BRCA cis rs11123610 0.520 rs7576701 chr2:3718227 T/C cg19052272 chr2:3704530 ALLC -0.45 -10.05 -0.37 3.56e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs9435341 0.896 rs1730850 chr1:107597988 C/T cg09367891 chr1:107599246 PRMT6 -0.55 -10.15 -0.37 1.58e-22 Facial morphology (factor 21, depth of nasal alae); BRCA trans rs7647973 0.626 rs6809879 chr3:49834571 A/G cg21659725 chr3:3221576 CRBN 0.47 8.69 0.33 3e-17 Menarche (age at onset); BRCA cis rs34779708 0.931 rs72789687 chr10:35372489 G/A cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs730775 0.505 rs325004 chr6:44270365 C/G cg21130236 chr6:44246755 TMEM151B -0.29 -8.23 -0.31 1.02e-15 Monocyte percentage of white cells;Monocyte count; BRCA cis rs1865721 0.804 rs4510115 chr18:73209635 G/A cg26385618 chr18:73139727 C18orf62 -0.35 -8.03 -0.3 4.81e-15 Intelligence; BRCA cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg25036284 chr2:26402008 FAM59B -0.79 -12.35 -0.44 1.43e-31 Gut microbiome composition (summer); BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg16145915 chr7:1198662 ZFAND2A -0.68 -16.8 -0.55 9.94e-53 Longevity;Endometriosis; BRCA cis rs651907 0.557 rs1056579 chr3:101397877 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.59 0.53 1.06e-46 Colorectal cancer; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg27170947 chr2:26402098 FAM59B -0.65 -11.22 -0.41 8.42e-27 Gut microbiome composition (summer); BRCA cis rs17620991 1.000 rs17688247 chr7:40832144 C/T cg05119115 chr7:40866195 C7orf10 -0.57 -8.74 -0.33 2.12e-17 Alcohol dependence; BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg09877947 chr5:131593287 PDLIM4 0.43 10.76 0.39 6.06e-25 Breast cancer; BRCA cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.38 0.35 1.11e-19 Height; BRCA cis rs8180040 0.627 rs6442059 chr3:47187075 C/G cg27129171 chr3:47204927 SETD2 0.72 17.54 0.57 1.61e-56 Colorectal cancer; BRCA cis rs1401999 1.000 rs939336 chr3:183685534 A/G cg01324343 chr3:183735012 ABCC5 0.83 20.95 0.64 1.44e-74 Anterior chamber depth; BRCA cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.16 0.31 1.77e-15 Breast cancer; BRCA cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs977987 0.872 rs1559339 chr16:75318646 A/G cg03315344 chr16:75512273 CHST6 0.51 11.72 0.42 7.51e-29 Dupuytren's disease; BRCA cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg06636001 chr8:8085503 FLJ10661 0.49 10.94 0.4 1.23e-25 Mood instability; BRCA cis rs2304069 0.837 rs10041451 chr5:149385197 A/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.82 16.46 0.55 5.25e-51 HIV-1 control; BRCA cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg08917208 chr2:24149416 ATAD2B 1.09 15.66 0.53 4.98e-47 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7727544 0.645 rs272857 chr5:131685297 G/A cg07395648 chr5:131743802 NA -0.39 -9.61 -0.36 1.69e-20 Blood metabolite levels; BRCA cis rs727479 0.523 rs700518 chr15:51529112 C/T cg19946085 chr15:51559439 CYP19A1 0.3 8.31 0.31 5.82e-16 Estradiol levels; BRCA cis rs208520 1.000 rs208523 chr6:66954195 G/C cg07460842 chr6:66804631 NA -0.86 -14.32 -0.49 1.47e-40 Exhaled nitric oxide output; BRCA trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.53 16.45 0.55 5.74e-51 Intelligence (multi-trait analysis); BRCA cis rs9462846 0.959 rs7750915 chr6:42882067 C/T cg05552183 chr6:42928497 GNMT 0.48 8.15 0.31 1.99e-15 Blood protein levels; BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg24531977 chr5:56204891 C5orf35 0.86 18.07 0.58 2.96e-59 Initial pursuit acceleration; BRCA cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.53 0.5 1.53e-41 Motion sickness; BRCA cis rs7617773 0.780 rs6782166 chr3:48351683 A/G cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs312273 0.806 rs7955172 chr12:41356309 A/T cg17827154 chr12:41323612 CNTN1 -0.42 -10.98 -0.4 8.04e-26 Bipolar disorder; BRCA cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.584 rs55945625 chr6:8371367 C/T cg21535247 chr6:8435926 SLC35B3 -0.37 -8.37 -0.31 3.54e-16 Motion sickness; BRCA cis rs72781680 0.898 rs12623079 chr2:24103749 G/A cg08917208 chr2:24149416 ATAD2B 0.92 13.5 0.47 9.78e-37 Lymphocyte counts; BRCA cis rs2153535 0.580 rs7742794 chr6:8459723 C/A cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.47e-68 Mean platelet volume; BRCA cis rs600806 0.778 rs11101960 chr1:110008778 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.38 0.31 3.29e-16 Intelligence (multi-trait analysis); BRCA cis rs4988958 0.565 rs3771154 chr2:103039360 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.3 0.31 6.13e-16 Asthma (childhood onset); BRCA trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg17470723 chr8:74884337 TCEB1 0.41 8.84 0.33 9.49e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs936229 0.813 rs1378938 chr15:75096443 T/C cg14664628 chr15:75095509 CSK -0.92 -27.9 -0.74 1.19e-112 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg01802117 chr1:53393560 SCP2 -0.41 -9.13 -0.34 8.75e-19 Monocyte count; BRCA cis rs644799 1.000 rs617999 chr11:95589935 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.44 9.23 0.34 3.82e-19 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA trans rs7824557 0.815 rs2736372 chr8:11106041 T/C cg06636001 chr8:8085503 FLJ10661 -0.38 -8.13 -0.31 2.27e-15 Retinal vascular caliber; BRCA cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg05868516 chr6:26286170 HIST1H4H 0.49 11.03 0.4 4.95e-26 Educational attainment; BRCA cis rs7572733 0.534 rs7604700 chr2:198718630 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.12 0.37 1.95e-22 Dermatomyositis; BRCA cis rs9309473 0.583 rs6705203 chr2:73574600 T/C cg20560298 chr2:73613845 ALMS1 -0.42 -10.99 -0.4 7.59e-26 Metabolite levels; BRCA trans rs208520 0.874 rs208514 chr6:66945520 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.82 -15.33 -0.52 2.03e-45 Exhaled nitric oxide output; BRCA cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.65 16.42 0.54 8.19e-51 Colorectal cancer; BRCA cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.14 0.37 1.62e-22 Bladder cancer; BRCA cis rs13046373 0.507 rs11088139 chr21:31978884 T/G cg14062083 chr21:31802829 KRTAP13-4 0.35 9.55 0.35 2.8e-20 HDL cholesterol; BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg03354898 chr7:1950403 MAD1L1 -0.49 -9.72 -0.36 6.35e-21 Bipolar disorder and schizophrenia; BRCA cis rs7582180 0.663 rs4850929 chr2:100990707 A/C cg14675211 chr2:100938903 LONRF2 0.43 9.51 0.35 3.82e-20 Intelligence (multi-trait analysis); BRCA cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.5 -0.38 6.73e-24 Reticulocyte count; BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg04944784 chr2:26401820 FAM59B -0.67 -11.25 -0.41 6.79e-27 Gut microbiome composition (summer); BRCA cis rs12986413 0.967 rs4807211 chr19:2174643 G/A cg09261902 chr19:2140048 AP3D1 0.38 10.05 0.37 3.64e-22 Height; BRCA cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg15017067 chr4:17643749 FAM184B 0.3 8.42 0.32 2.39e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs57590327 0.528 rs11707026 chr3:81694044 C/A cg07356753 chr3:81810745 GBE1 -0.43 -9.91 -0.37 1.2e-21 Extraversion; BRCA cis rs9815354 1.000 rs56121764 chr3:41883975 T/C cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg24531977 chr5:56204891 C5orf35 1.01 20.62 0.63 8.79e-73 Initial pursuit acceleration; BRCA cis rs3820928 0.845 rs13419076 chr2:227873028 A/G cg11843606 chr2:227700838 RHBDD1 -0.36 -7.99 -0.3 6.28e-15 Pulmonary function; BRCA cis rs34779708 0.931 rs7923217 chr10:35309589 A/G cg03585969 chr10:35415529 CREM 0.44 9.39 0.35 1.02e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs8062405 1.000 rs72793812 chr16:28840381 A/G cg09754948 chr16:28834200 ATXN2L 0.48 9.04 0.34 1.9e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6087990 0.731 rs2424897 chr20:31338098 A/T cg13636640 chr20:31349939 DNMT3B 0.72 21.59 0.65 4.76e-78 Ulcerative colitis; BRCA cis rs61990749 0.597 rs8003691 chr14:78211225 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.54 0.38 4.79e-24 Fibroblast growth factor basic levels; BRCA cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg03213289 chr20:61660250 NA 0.63 16.23 0.54 7.45e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14442939 chr10:27389572 ANKRD26 -0.68 -10.86 -0.39 2.56e-25 Breast cancer; BRCA cis rs72781680 0.560 rs72781698 chr2:24271506 C/T cg20701182 chr2:24300061 SF3B14 0.68 12.67 0.45 5.66e-33 Lymphocyte counts; BRCA cis rs12986413 0.934 rs6510645 chr19:2158398 T/C cg09261902 chr19:2140048 AP3D1 0.4 10.6 0.39 2.72e-24 Height; BRCA cis rs11758351 1.000 rs79868973 chr6:26189312 C/G cg01420254 chr6:26195488 NA 0.56 8.92 0.33 5.02e-18 Gout;Renal underexcretion gout; BRCA cis rs17270561 0.609 rs9358883 chr6:25755515 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.8e-17 Iron status biomarkers; BRCA cis rs67460515 0.567 rs34691229 chr3:160876897 G/T cg03342759 chr3:160939853 NMD3 -0.73 -15.13 -0.51 1.91e-44 Parkinson's disease; BRCA cis rs7927592 0.913 rs10896347 chr11:68353127 G/A cg20283391 chr11:68216788 NA -0.45 -8.93 -0.33 4.39e-18 Total body bone mineral density; BRCA cis rs796364 0.789 rs1653297 chr2:201075483 C/T cg17644776 chr2:200775616 C2orf69 0.45 8.59 0.32 6.67e-17 Schizophrenia; BRCA cis rs7659604 0.643 rs6838881 chr4:122663616 A/T cg19748678 chr4:122722346 EXOSC9 0.42 8.67 0.32 3.48e-17 Type 2 diabetes; BRCA cis rs2742417 0.603 rs7631818 chr3:45775931 A/T cg04837898 chr3:45731254 SACM1L -0.38 -7.81 -0.3 2.41e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.19 0.4 1.17e-26 Bipolar disorder; BRCA cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg11752832 chr7:134001865 SLC35B4 0.42 9.19 0.34 5.61e-19 Mean platelet volume; BRCA cis rs9435341 0.965 rs9435441 chr1:107603330 C/G cg09367891 chr1:107599246 PRMT6 -0.41 -8.2 -0.31 1.36e-15 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs10504229 0.683 rs7460059 chr8:58111561 C/T cg20607798 chr8:58055168 NA 0.47 8.1 0.31 2.72e-15 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg13319975 chr6:146136371 FBXO30 -0.38 -8.63 -0.32 4.69e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4820539 0.902 rs9612237 chr22:23472954 T/C cg14186256 chr22:23484241 RTDR1 0.77 23.66 0.68 2.35e-89 Bone mineral density; BRCA cis rs7590720 1.000 rs4674058 chr2:216909368 A/G cg12620499 chr2:216877984 MREG 0.79 21.43 0.65 3.41e-77 Alcohol dependence; BRCA cis rs992157 0.965 rs13427681 chr2:219167563 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.61 14.16 0.49 8.43e-40 Colorectal cancer; BRCA cis rs2882667 0.728 rs10068786 chr5:138276944 C/T cg04439458 chr5:138467593 SIL1 -0.36 -8.71 -0.33 2.7e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 0.764 rs11716539 chr3:47186503 G/T cg27129171 chr3:47204927 SETD2 0.76 19.77 0.62 2.89e-68 Colorectal cancer; BRCA cis rs1043763 0.826 rs11043307 chr12:122494845 A/G cg14400030 chr12:122498111 BCL7A 0.69 15.16 0.51 1.46e-44 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs7666738 0.830 rs10001701 chr4:98918871 G/C cg05340658 chr4:99064831 C4orf37 0.61 14.48 0.5 2.58e-41 Colonoscopy-negative controls vs population controls; BRCA trans rs561341 1.000 rs7214017 chr17:30332220 T/C cg20587970 chr11:113659929 NA -0.95 -18.66 -0.59 2.29e-62 Hip circumference adjusted for BMI; BRCA cis rs4642101 0.512 rs12629892 chr3:12818920 A/G cg24848339 chr3:12840334 CAND2 0.46 12.11 0.43 1.59e-30 QRS complex (12-leadsum); BRCA cis rs250677 0.524 rs183140 chr5:148438803 G/T cg12140854 chr5:148520817 ABLIM3 -0.37 -8.48 -0.32 1.51e-16 Breast cancer; BRCA trans rs11098499 0.863 rs28718422 chr4:120466304 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs11190604 1.000 rs7088512 chr10:102303498 G/T cg07080220 chr10:102295463 HIF1AN 0.58 13.43 0.47 2.14e-36 Palmitoleic acid (16:1n-7) levels; BRCA trans rs62103177 0.810 rs62103195 chr18:77629693 T/C cg05926928 chr17:57297772 GDPD1 1.43 18.18 0.58 7.57e-60 Opioid sensitivity; BRCA cis rs1005277 0.579 rs2472181 chr10:38386764 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA trans rs1973993 0.603 rs2391799 chr1:97024329 A/G cg10631902 chr5:14652156 NA 0.38 9.52 0.35 3.59e-20 Weight; BRCA cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg12935359 chr14:103987150 CKB 0.65 15.04 0.51 5.76e-44 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.822 rs9972180 chr14:56073732 G/T cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.91 0.3 1.15e-14 Putamen volume; BRCA cis rs4478858 0.735 rs12126725 chr1:31805853 G/T cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg03929089 chr4:120376271 NA 0.57 9.31 0.35 2.07e-19 Axial length; BRCA cis rs1030877 0.521 rs2576747 chr2:105978676 A/T cg02079111 chr2:105885981 TGFBRAP1 0.49 10.68 0.39 1.25e-24 Obesity-related traits; BRCA cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.16e-15 Uric acid levels; BRCA cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg06453172 chr10:134556979 INPP5A 0.56 10.96 0.4 9.93e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg25427524 chr10:38739819 LOC399744 -0.68 -16.38 -0.54 1.31e-50 Extrinsic epigenetic age acceleration; BRCA cis rs6089584 0.850 rs881993 chr20:60623862 A/G cg13770153 chr20:60521292 NA -0.44 -9.85 -0.36 2.18e-21 Body mass index; BRCA cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.41 -8.7 -0.33 2.9e-17 Rheumatoid arthritis; BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg04166393 chr7:2884313 GNA12 0.49 9.16 0.34 6.93e-19 Height; BRCA trans rs61931739 0.534 rs73103090 chr12:34098801 C/T cg26384229 chr12:38710491 ALG10B 0.63 13.24 0.46 1.53e-35 Morning vs. evening chronotype; BRCA cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg17366294 chr4:99064904 C4orf37 0.52 11.56 0.42 3.32e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs1997103 1.000 rs2177802 chr7:55410789 G/A cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs16854884 0.606 rs60676654 chr3:143734937 A/G cg06585982 chr3:143692056 C3orf58 0.43 9.0 0.34 2.63e-18 Economic and political preferences (feminism/equality); BRCA cis rs2070488 0.804 rs35463537 chr3:38498248 T/C cg24069376 chr3:38537580 EXOG 0.32 9.08 0.34 1.36e-18 Electrocardiographic conduction measures; BRCA cis rs4662945 0.603 rs10168574 chr2:130267823 C/T cg05962382 chr2:130345044 NA -0.34 -8.01 -0.3 5.42e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg08885076 chr2:99613938 TSGA10 -0.54 -12.53 -0.44 2.21e-32 Chronic sinus infection; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg03188948 chr7:1209495 NA 0.67 11.11 0.4 2.52e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3806843 0.766 rs2251860 chr5:140048209 T/C cg26395211 chr5:140044315 WDR55 0.38 8.72 0.33 2.43e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs2070488 0.965 rs3762788 chr3:38493852 C/A cg24069376 chr3:38537580 EXOG 0.41 11.94 0.43 8.01e-30 Electrocardiographic conduction measures; BRCA cis rs965469 1.000 rs6051736 chr20:3296898 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.29 -0.38 4.41e-23 IFN-related cytopenia; BRCA cis rs929596 0.585 rs2018985 chr2:234648860 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.37 -9.29 -0.34 2.44e-19 Total bilirubin levels in HIV-1 infection; BRCA cis rs1891275 0.515 rs7098763 chr10:93444827 C/T cg07889827 chr10:93443413 NA -0.44 -12.37 -0.44 1.2e-31 Intelligence (multi-trait analysis); BRCA cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg20701182 chr2:24300061 SF3B14 0.67 9.77 0.36 4.1e-21 Lymphocyte counts; BRCA cis rs2953174 0.744 rs2975748 chr2:241518989 A/G cg07929629 chr2:241523174 NA 0.49 8.45 0.32 2.04e-16 Bipolar disorder; BRCA cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg18876405 chr7:65276391 NA 0.55 13.29 0.47 8.91e-36 Aortic root size; BRCA cis rs950173 1.000 rs6716901 chr2:172673453 C/T cg13550731 chr2:172543902 DYNC1I2 -0.64 -9.49 -0.35 4.48e-20 Hippocampal volume; BRCA cis rs853679 0.546 rs175597 chr6:27810626 T/C cg26587870 chr6:27730563 NA -0.56 -8.5 -0.32 1.29e-16 Depression; BRCA cis rs514406 0.505 rs269289 chr1:53167151 A/C cg16325326 chr1:53192061 ZYG11B 0.79 22.34 0.66 3.74e-82 Monocyte count; BRCA cis rs11098499 0.909 rs7659501 chr4:120371552 G/T cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.37 -12.84 -0.45 9.66e-34 Bipolar disorder; BRCA cis rs2576037 0.583 rs616900 chr18:44410849 T/A cg19077165 chr18:44547161 KATNAL2 -0.59 -13.19 -0.46 2.49e-35 Personality dimensions; BRCA cis rs7586879 0.593 rs11689543 chr2:25130440 A/T cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.31e-28 Body mass index; BRCA cis rs4363385 0.818 rs1334848 chr1:153004721 A/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.22 -0.34 4.37e-19 Inflammatory skin disease; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg04944784 chr2:26401820 FAM59B 0.99 16.56 0.55 1.61e-51 Gut microbiome composition (summer); BRCA cis rs4820539 1.000 rs5759598 chr22:23480962 T/G cg14186256 chr22:23484241 RTDR1 0.72 19.53 0.61 5.59e-67 Bone mineral density; BRCA cis rs12545109 0.917 rs1370304 chr8:57322822 G/C cg09654669 chr8:57350985 NA -0.4 -8.62 -0.32 5.33e-17 Obesity-related traits; BRCA cis rs13191362 0.573 rs1877769 chr6:163252315 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.47 8.36 0.31 3.9e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2251381 0.750 rs8129616 chr21:30520085 C/T cg24692254 chr21:30365293 RNF160 -0.64 -14.45 -0.5 3.86e-41 Selective IgA deficiency; BRCA trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg15704280 chr7:45808275 SEPT13 0.6 10.66 0.39 1.57e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs7551345 0.653 rs6425719 chr1:31700777 T/C cg19084893 chr1:31688959 NA -0.49 -10.46 -0.38 9.21e-24 Schizophrenia; BRCA cis rs10924970 0.934 rs12402243 chr1:235431792 A/C cg26050004 chr1:235667680 B3GALNT2 0.34 8.48 0.32 1.59e-16 Asthma; BRCA cis rs6089584 0.888 rs6061973 chr20:60610870 C/T cg13770153 chr20:60521292 NA -0.41 -9.03 -0.34 2e-18 Body mass index; BRCA trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg15556689 chr8:8085844 FLJ10661 -0.37 -10.14 -0.37 1.6e-22 Neuroticism; BRCA cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.66 0.39 1.5e-24 Bipolar disorder; BRCA cis rs2243480 1.000 rs13247184 chr7:65358928 A/G cg18252515 chr7:66147081 NA -0.87 -12.08 -0.43 2.13e-30 Diabetic kidney disease; BRCA cis rs977987 0.806 rs4888386 chr16:75389740 A/G cg03315344 chr16:75512273 CHST6 0.51 11.95 0.43 7.54e-30 Dupuytren's disease; BRCA cis rs155076 0.938 rs261375 chr13:21871882 A/G cg14456004 chr13:21872349 NA 1.2 22.11 0.66 6.72e-81 White matter hyperintensity burden; BRCA cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg11822812 chr5:140052017 DND1 -0.3 -8.22 -0.31 1.16e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2180341 1.000 rs9375499 chr6:127618072 T/C cg27446573 chr6:127587934 RNF146 0.9 21.07 0.64 2.99e-75 Breast cancer; BRCA trans rs75804782 0.521 rs2117691 chr2:239414734 C/T cg01134436 chr17:81009848 B3GNTL1 0.68 8.55 0.32 9.09e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg10802521 chr3:52805072 NEK4 0.34 9.26 0.34 3.03e-19 Bipolar disorder; BRCA cis rs908922 0.584 rs71626721 chr1:152532745 A/G cg20991723 chr1:152506922 NA 0.37 8.25 0.31 9.17e-16 Hair morphology; BRCA cis rs7903847 0.602 rs7916665 chr10:99157573 T/G cg08345082 chr10:99160200 RRP12 -0.29 -8.58 -0.32 7.24e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs9640161 0.659 rs7806429 chr7:150013393 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.49 -12.61 -0.45 1.03e-32 Blood protein levels;Circulating chemerin levels; BRCA cis rs6435161 0.959 rs10189685 chr2:203488449 G/A cg18429434 chr2:203499731 FAM117B -0.43 -9.01 -0.34 2.38e-18 Total cholesterol levels; BRCA cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg05025164 chr4:1340916 KIAA1530 0.75 15.57 0.52 1.36e-46 Longevity; BRCA cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg06784218 chr1:46089804 CCDC17 0.5 12.14 0.43 1.17e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17253792 0.822 rs112238223 chr14:56056144 C/A cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs11997175 0.766 rs6995220 chr8:33708919 C/A ch.8.33884649F chr8:33765107 NA 0.35 8.33 0.31 4.84e-16 Body mass index; BRCA cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg04553112 chr3:125709451 NA -0.55 -8.68 -0.32 3.17e-17 Blood pressure (smoking interaction); BRCA trans rs783540 0.967 rs7494860 chr15:83334419 A/G cg18393722 chr15:85113863 UBE2QP1 0.25 7.84 0.3 1.89e-14 Schizophrenia; BRCA cis rs7715811 1.000 rs6860236 chr5:13762013 C/T cg07548982 chr5:13769939 DNAH5 -0.38 -8.31 -0.31 5.55e-16 Subclinical atherosclerosis traits (other); BRCA cis rs7520050 0.667 rs11211176 chr1:46223086 C/T cg03146154 chr1:46216737 IPP -0.36 -8.41 -0.32 2.76e-16 Red blood cell count;Reticulocyte count; BRCA cis rs911555 0.755 rs2273702 chr14:103918182 C/G cg12935359 chr14:103987150 CKB 0.56 12.72 0.45 3.2e-33 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.875 rs6981523 chr8:11061792 C/T cg06636001 chr8:8085503 FLJ10661 -0.49 -10.01 -0.37 5.3e-22 Triglycerides; BRCA cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg04990556 chr1:26633338 UBXN11 -0.47 -9.32 -0.35 1.84e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg23583168 chr7:148888333 NA -0.81 -18.24 -0.59 3.63e-60 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6061231 1.000 rs6061231 chr20:60956917 C/A cg22601191 chr20:60968625 CABLES2 0.34 8.5 0.32 1.38e-16 Colorectal cancer; BRCA cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg00409905 chr10:38381863 ZNF37A -0.5 -10.44 -0.38 1.14e-23 Extrinsic epigenetic age acceleration; BRCA cis rs425277 0.606 rs377283 chr1:2075570 T/C cg19257562 chr1:2043853 PRKCZ -0.35 -9.36 -0.35 1.38e-19 Height; BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00166722 chr3:10149974 C3orf24 0.67 13.49 0.47 1.13e-36 Alzheimer's disease; BRCA cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg19678392 chr7:94953810 PON1 -0.41 -8.58 -0.32 7.05e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9487051 0.502 rs9386781 chr6:109584520 G/A cg01475377 chr6:109611718 NA -0.44 -10.44 -0.38 1.1e-23 Reticulocyte fraction of red cells; BRCA cis rs12477438 0.520 rs36071868 chr2:99737120 G/A cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.34e-23 Chronic sinus infection; BRCA cis rs7424096 0.527 rs4670637 chr2:37164857 T/G cg14987922 chr2:37194071 STRN 0.4 8.57 0.32 8.05e-17 High light scatter reticulocyte percentage of red cells; BRCA cis rs10911232 0.507 rs10911198 chr1:182997318 G/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.68 0.55 4.17e-52 Hypertriglyceridemia; BRCA cis rs28374715 0.681 rs7168307 chr15:41620534 A/G cg18705301 chr15:41695430 NDUFAF1 -0.84 -20.16 -0.62 2.64e-70 Ulcerative colitis; BRCA cis rs12618769 0.625 rs4850880 chr2:99212417 C/T cg10123293 chr2:99228465 UNC50 0.42 8.53 0.32 1.07e-16 Bipolar disorder; BRCA cis rs758324 0.617 rs12719447 chr5:131118100 C/A cg06307176 chr5:131281290 NA 0.57 12.06 0.43 2.55e-30 Alzheimer's disease in APOE e4- carriers; BRCA cis rs11190604 1.000 rs2495747 chr10:102328247 C/T cg07080220 chr10:102295463 HIF1AN 0.54 12.57 0.45 1.52e-32 Palmitoleic acid (16:1n-7) levels; BRCA cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg25019033 chr10:957182 NA -0.41 -8.67 -0.32 3.58e-17 Eosinophil percentage of granulocytes; BRCA cis rs847577 0.646 rs10270222 chr7:97781799 C/T cg21770322 chr7:97807741 LMTK2 -0.45 -12.0 -0.43 4.64e-30 Breast cancer; BRCA cis rs9815354 0.812 rs73071236 chr3:41992042 A/G cg03022575 chr3:42003672 ULK4 0.65 9.28 0.34 2.54e-19 Pulse pressure;Diastolic blood pressure; BRCA cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg14061069 chr19:46274453 DMPK -0.46 -11.56 -0.42 3.37e-28 Coronary artery disease; BRCA cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg10845886 chr2:3471009 TTC15 -0.54 -11.99 -0.43 4.9e-30 Neurofibrillary tangles; BRCA cis rs7772486 0.686 rs9399565 chr6:146081906 G/T cg13319975 chr6:146136371 FBXO30 0.35 8.09 0.3 3.08e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs708547 0.874 rs73242624 chr4:57847420 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -9.03 -0.34 2.03e-18 Response to bleomycin (chromatid breaks); BRCA trans rs1459104 1.000 rs12802877 chr11:55270032 C/T cg15704280 chr7:45808275 SEPT13 0.65 8.14 0.31 2.12e-15 Body mass index; BRCA cis rs6545883 0.525 rs1621048 chr2:61364216 C/G cg15711740 chr2:61764176 XPO1 0.44 10.61 0.39 2.5300000000000002e-24 Tuberculosis; BRCA cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.37 0.38 2.12e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1003719 0.788 rs9975168 chr21:38450557 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.5 -0.5 2.03e-41 Eye color traits; BRCA cis rs1577917 1.000 rs2324843 chr6:86617501 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -14.28 -0.49 2.33e-40 Response to antipsychotic treatment; BRCA cis rs16857609 0.564 rs1478581 chr2:218292652 C/T cg15335768 chr2:218268053 DIRC3 -0.42 -9.75 -0.36 5.02e-21 Breast cancer;Breast cancer (estrogen-receptor negative); BRCA cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg08085267 chr17:45401833 C17orf57 -0.58 -11.73 -0.42 6.75e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg23788917 chr6:8435910 SLC35B3 0.47 10.21 0.37 8.59e-23 Motion sickness; BRCA cis rs7312933 1.000 rs3229 chr12:42475888 G/A cg17420585 chr12:42539391 GXYLT1 -0.49 -10.61 -0.39 2.57e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg16606324 chr3:10149918 C3orf24 0.57 11.29 0.41 4.57e-27 Alzheimer's disease; BRCA cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg20701182 chr2:24300061 SF3B14 0.55 8.53 0.32 1.09e-16 Lymphocyte counts; BRCA cis rs875971 0.895 rs7782806 chr7:65657897 C/T cg18876405 chr7:65276391 NA -0.51 -11.63 -0.42 1.67e-28 Aortic root size; BRCA trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg08885201 chr16:69419692 TERF2 0.52 7.86 0.3 1.64e-14 Response to platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs35110281 0.720 rs162394 chr21:44943550 C/G cg21573476 chr21:45109991 RRP1B 0.36 9.23 0.34 4e-19 Mean corpuscular volume; BRCA cis rs738322 0.967 rs132971 chr22:38561911 T/G cg25457927 chr22:38595422 NA -0.32 -11.68 -0.42 1.02e-28 Cutaneous nevi; BRCA trans rs7647973 0.626 rs7649428 chr3:49868876 A/T cg21659725 chr3:3221576 CRBN 0.47 8.78 0.33 1.54e-17 Menarche (age at onset); BRCA cis rs7582180 0.591 rs2241810 chr2:101011877 T/C cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.1e-14 Intelligence (multi-trait analysis); BRCA cis rs796364 0.806 rs79725795 chr2:201083534 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.62 -8.75 -0.33 1.9e-17 Schizophrenia; BRCA cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg00071950 chr4:10020882 SLC2A9 0.4 9.43 0.35 7.27e-20 Bone mineral density; BRCA cis rs4595586 0.525 rs7970652 chr12:39374873 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs67311347 0.955 rs4974067 chr3:40374551 C/T cg09455208 chr3:40491958 NA 0.4 9.45 0.35 6.22e-20 Renal cell carcinoma; BRCA cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg12011299 chr4:100065546 ADH4 0.41 10.77 0.39 5.57e-25 Alcohol dependence; BRCA cis rs7246657 0.943 rs2112923 chr19:37940327 C/T cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.88e-28 Coronary artery calcification; BRCA cis rs13315871 1.000 rs13096020 chr3:58367771 G/A cg20936604 chr3:58311152 NA -0.62 -7.94 -0.3 9.28e-15 Cholesterol, total; BRCA cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg18270830 chr10:32634957 EPC1 0.58 9.94 0.37 9.22e-22 Sexual dysfunction (female); BRCA cis rs17270561 0.609 rs9358876 chr6:25738956 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.81e-18 Iron status biomarkers; BRCA cis rs561341 1.000 rs542132 chr17:30307193 A/T cg23018236 chr17:30244563 NA -0.61 -10.05 -0.37 3.63e-22 Hip circumference adjusted for BMI; BRCA cis rs4363385 0.720 rs1611764 chr1:152957887 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.42 -0.35 8.35e-20 Inflammatory skin disease; BRCA trans rs6598955 0.671 rs11247884 chr1:26577338 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs8114671 0.562 rs2378294 chr20:33500378 G/A cg24642439 chr20:33292090 TP53INP2 0.42 9.06 0.34 1.58e-18 Height; BRCA cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.83 -0.3 2.04e-14 Aortic root size; BRCA cis rs13040088 1.000 rs6090159 chr20:61531351 C/G cg23096297 chr20:61557774 DIDO1 0.89 17.8 0.58 7.44e-58 Menopause (age at onset); BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.44 8.45 0.32 2.01e-16 Lymphocyte counts; BRCA cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg13319975 chr6:146136371 FBXO30 -0.43 -10.12 -0.37 2.01e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs12579753 0.956 rs7965168 chr12:82184467 C/A cg07988820 chr12:82153109 PPFIA2 -0.59 -9.67 -0.36 9.43e-21 Resting heart rate; BRCA cis rs6545883 0.929 rs10200055 chr2:61628017 T/A cg15711740 chr2:61764176 XPO1 0.54 13.59 0.47 3.73e-37 Tuberculosis; BRCA trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.54 0.5 1.35e-41 Morning vs. evening chronotype; BRCA cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg01858014 chr14:56050164 KTN1 -0.77 -11.27 -0.41 5.52e-27 Putamen volume; BRCA cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg10253484 chr15:75165896 SCAMP2 -0.56 -11.59 -0.42 2.62e-28 Breast cancer; BRCA cis rs2749592 0.505 rs7915670 chr10:37870212 T/C cg25427524 chr10:38739819 LOC399744 0.59 13.17 0.46 3.36e-35 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs877282 0.838 rs11253373 chr10:774857 A/G cg17470449 chr10:769945 NA 0.51 8.67 0.32 3.53e-17 Uric acid levels; BRCA cis rs2832191 0.765 rs2832162 chr21:30461808 G/A cg08807101 chr21:30365312 RNF160 0.66 17.14 0.56 1.9e-54 Dental caries; BRCA trans rs62103177 0.564 rs2115996 chr18:77701007 C/G cg05926928 chr17:57297772 GDPD1 1.15 15.12 0.51 2.2e-44 Opioid sensitivity; BRCA cis rs10883723 0.773 rs2296587 chr10:104245588 G/A cg22532475 chr10:104410764 TRIM8 -0.3 -7.84 -0.3 1.89e-14 Allergic disease (asthma, hay fever or eczema); BRCA trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.8 -0.65 3.28e-79 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg26395211 chr5:140044315 WDR55 0.35 7.89 0.3 1.35e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs61931739 0.500 rs7977186 chr12:34431486 C/G cg06521331 chr12:34319734 NA -0.55 -9.98 -0.37 6.63e-22 Morning vs. evening chronotype; BRCA cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg13175981 chr1:150552382 MCL1 0.51 11.18 0.4 1.21e-26 Tonsillectomy; BRCA cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.75 15.41 0.52 8.18e-46 Smoking behavior; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg04944784 chr2:26401820 FAM59B 1.0 16.65 0.55 5.96e-52 Gut microbiome composition (summer); BRCA trans rs3749237 1.000 rs11130214 chr3:49735746 C/G cg21659725 chr3:3221576 CRBN -0.49 -11.79 -0.42 3.79e-29 Resting heart rate; BRCA cis rs7246967 0.673 rs55744741 chr19:22959973 C/T cg23217946 chr19:22817039 ZNF492 0.5 9.11 0.34 1.04e-18 Bronchopulmonary dysplasia; BRCA cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 13.81 0.48 3.62e-38 Colorectal cancer; BRCA cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg05340658 chr4:99064831 C4orf37 0.66 16.11 0.54 3.02e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs9322193 0.607 rs4870078 chr6:150201812 A/G cg13206674 chr6:150067644 NUP43 -0.32 -8.7 -0.33 2.79e-17 Lung cancer; BRCA cis rs56399783 0.901 rs6967664 chr7:2816384 A/G cg19731401 chr7:2775893 GNA12 0.5 8.1 0.31 2.79e-15 Childhood ear infection; BRCA cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg10057126 chr4:77819792 ANKRD56 0.68 15.42 0.52 7.78e-46 Emphysema distribution in smoking; BRCA cis rs12188164 0.543 rs2434694 chr5:462734 C/T cg26850624 chr5:429559 AHRR 0.33 7.88 0.3 1.37e-14 Cystic fibrosis severity; BRCA cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg23939001 chr4:940644 TMEM175 0.39 8.89 0.33 6e-18 Sjögren's syndrome; BRCA cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.16e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2625529 0.730 rs35713471 chr15:72459971 C/A cg16672083 chr15:72433130 SENP8 -0.84 -17.75 -0.57 1.34e-57 Red blood cell count; BRCA cis rs208520 0.526 rs7771233 chr6:66819784 A/G cg07460842 chr6:66804631 NA -1.11 -34.31 -0.81 4.23e-147 Exhaled nitric oxide output; BRCA cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.85 0.42 1.99e-29 Homoarginine levels; BRCA cis rs1163251 0.837 rs660073 chr1:120245173 T/C cg19096424 chr1:120255104 PHGDH 0.45 10.44 0.38 1.2e-23 Blood metabolite levels; BRCA cis rs8048589 0.515 rs12443524 chr16:12239979 A/G cg02910054 chr16:12241554 SNX29 -0.45 -9.08 -0.34 1.36e-18 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); BRCA cis rs113835537 0.597 rs7116921 chr11:66303854 T/C cg24851651 chr11:66362959 CCS 0.47 8.91 0.33 5.33e-18 Airway imaging phenotypes; BRCA cis rs6754459 0.666 rs11674266 chr2:3705291 A/G cg19052272 chr2:3704530 ALLC -0.36 -8.41 -0.32 2.71e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs7582180 0.638 rs9973536 chr2:100942243 C/T cg14675211 chr2:100938903 LONRF2 0.43 9.94 0.37 9.92e-22 Intelligence (multi-trait analysis); BRCA cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.61 9.25 0.34 3.21e-19 Lung function (FEV1/FVC); BRCA cis rs13082711 0.911 rs67104968 chr3:27510304 A/G cg02860705 chr3:27208620 NA 0.52 10.33 0.38 3.05e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs9560113 0.881 rs9560111 chr13:112181289 C/T cg10483660 chr13:112241077 NA 0.32 7.98 0.3 6.63e-15 Menarche (age at onset); BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg24101359 chr6:42928495 GNMT 0.54 12.59 0.45 1.24e-32 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs2840044 1.000 rs11653310 chr17:33893378 C/G cg19694781 chr19:47549865 TMEM160 -0.46 -11.1 -0.4 2.56e-26 Response to radiotherapy in cancer (late toxicity); BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.72 16.16 0.54 1.68e-49 Lymphocyte counts; BRCA cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.84 12.5 0.44 3.17e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.7 -0.39 1.09e-24 Menarche (age at onset); BRCA cis rs7267979 0.932 rs6138600 chr20:25521346 A/T cg08601574 chr20:25228251 PYGB 0.35 8.39 0.32 3.06e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12310956 0.532 rs10844719 chr12:33987714 A/G cg06521331 chr12:34319734 NA -0.56 -10.84 -0.39 3.03e-25 Morning vs. evening chronotype; BRCA cis rs7715806 0.500 rs10515213 chr5:74980572 C/T cg19683494 chr5:74908142 NA -0.52 -8.49 -0.32 1.41e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.68 -11.52 -0.41 5.03e-28 Platelet count; BRCA cis rs9503598 0.636 rs7775474 chr6:3468224 T/C cg00476032 chr6:3446245 SLC22A23 0.38 9.3 0.35 2.28e-19 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs3820928 0.874 rs7421491 chr2:227839278 C/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.16 -0.31 1.79e-15 Pulmonary function; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg23708337 chr7:1209742 NA 0.55 11.74 0.42 6.08e-29 Longevity;Endometriosis; BRCA cis rs2839186 0.588 rs2839140 chr21:47616080 G/A cg12379764 chr21:47803548 PCNT 0.4 8.86 0.33 7.77e-18 Testicular germ cell tumor; BRCA cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg24812749 chr6:127587940 RNF146 0.87 20.07 0.62 7.99e-70 Breast cancer; BRCA cis rs7512552 0.839 rs698916 chr1:150388385 A/G cg15654264 chr1:150340011 RPRD2 0.37 8.13 0.31 2.26e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -7.89 -0.3 1.31e-14 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs35146811 0.735 rs1727140 chr7:99815399 T/A cg13334819 chr7:99746414 C7orf59 0.34 7.85 0.3 1.79e-14 Coronary artery disease; BRCA cis rs2625529 0.824 rs12592044 chr15:72419115 A/G cg16672083 chr15:72433130 SENP8 -0.84 -17.71 -0.57 2.19e-57 Red blood cell count; BRCA cis rs1198430 0.683 rs1198433 chr1:23756695 A/G cg19827787 chr1:23763612 ASAP3 0.33 9.32 0.35 1.8e-19 Total cholesterol levels; BRCA cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg11752832 chr7:134001865 SLC35B4 0.54 13.89 0.48 1.54e-38 Mean platelet volume; BRCA cis rs11608355 0.515 rs7136048 chr12:109903926 A/G cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs72781680 0.821 rs2339887 chr2:24198376 G/A cg08917208 chr2:24149416 ATAD2B 0.62 10.54 0.38 4.62e-24 Lymphocyte counts; BRCA cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg14349672 chr11:133703707 NA 0.33 8.34 0.31 4.44e-16 Childhood ear infection; BRCA cis rs9287719 0.674 rs6432130 chr2:10821557 T/C cg00105475 chr2:10696890 NA -0.39 -8.8 -0.33 1.24e-17 Prostate cancer; BRCA cis rs9470366 0.883 rs9462207 chr6:36627599 T/C cg08179530 chr6:36648295 CDKN1A 0.51 9.64 0.36 1.3e-20 QRS duration; BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -10.81 -0.39 3.91e-25 Longevity;Endometriosis; BRCA cis rs858239 0.601 rs10278700 chr7:23160529 T/C cg23682824 chr7:23144976 KLHL7 0.42 11.09 0.4 2.96e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg25703541 chr22:24373054 LOC391322 -0.69 -16.04 -0.54 6.43e-49 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7267979 0.934 rs2261115 chr20:25259807 G/A cg08601574 chr20:25228251 PYGB 0.36 8.8 0.33 1.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1580019 0.587 rs9638880 chr7:32552401 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.72 0.76 1.44e-122 Cognitive ability; BRCA cis rs2073300 1.000 rs12625160 chr20:23442008 T/C cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00475322 chr7:917719 C7orf20 -0.43 -11.24 -0.41 6.81e-27 Perceived unattractiveness to mosquitoes; BRCA cis rs10992471 0.603 rs12342019 chr9:95192508 C/T cg14631576 chr9:95140430 CENPP -0.39 -9.31 -0.35 1.96e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7100689 0.646 rs10749581 chr10:82141651 A/G cg01528321 chr10:82214614 TSPAN14 -0.82 -17.96 -0.58 1.1e-58 Post bronchodilator FEV1; BRCA cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg15605315 chr1:45957053 TESK2 0.47 9.77 0.36 4.19e-21 High light scatter reticulocyte count; BRCA cis rs28830936 0.966 rs2303518 chr15:42109975 T/G cg17847044 chr15:42102381 MAPKBP1 -0.4 -11.92 -0.43 1.03e-29 Diastolic blood pressure; BRCA cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg16325326 chr1:53192061 ZYG11B -0.76 -19.99 -0.62 2.04e-69 Monocyte count; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg00802000 chr16:706648 WDR90 -0.4 -9.52 -0.35 3.59e-20 Height; BRCA cis rs7246657 0.943 rs4801759 chr19:37954985 G/A cg18154014 chr19:37997991 ZNF793 0.62 11.64 0.42 1.49e-28 Coronary artery calcification; BRCA cis rs35110281 0.622 rs9977258 chr21:44976485 G/T cg04455712 chr21:45112962 RRP1B 0.36 9.1 0.34 1.16e-18 Mean corpuscular volume; BRCA trans rs6582630 0.519 rs4002440 chr12:38485012 A/G cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs1865721 0.755 rs3813081 chr18:73185096 A/G cg26385618 chr18:73139727 C18orf62 -0.33 -7.84 -0.3 1.87e-14 Intelligence; BRCA cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.85e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2992756 0.663 rs3007718 chr1:18808465 T/A cg14356550 chr1:18808102 KLHDC7A -0.4 -8.29 -0.31 6.67e-16 Breast cancer; BRCA cis rs2073300 0.609 rs6137917 chr20:23360369 G/A cg12062639 chr20:23401060 NAPB 0.94 13.34 0.47 5.3e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs3768617 0.510 rs2333620 chr1:183100555 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg13114125 chr14:105738426 BRF1 -0.48 -10.09 -0.37 2.69e-22 Mean platelet volume;Platelet distribution width; BRCA cis rs853679 0.546 rs200995 chr6:27813694 C/T cg26587870 chr6:27730563 NA 0.54 8.08 0.3 3.27e-15 Depression; BRCA cis rs7618915 1.000 rs7618915 chr3:52279594 G/A cg14092988 chr3:52407081 DNAH1 0.32 7.85 0.3 1.81e-14 Bipolar disorder; BRCA trans rs10242455 0.702 rs73401510 chr7:99065812 A/C cg09045935 chr12:6379348 NA 0.84 8.3 0.31 6.1e-16 Blood metabolite levels; BRCA cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg05025164 chr4:1340916 KIAA1530 0.34 7.85 0.3 1.78e-14 Longevity; BRCA cis rs12210905 0.688 rs12205044 chr6:27478990 A/G cg08851530 chr6:28072375 NA 0.82 7.92 0.3 1.02e-14 Hip circumference adjusted for BMI; BRCA cis rs4742903 0.967 rs10820605 chr9:106881402 C/T cg21169611 chr9:106856078 SMC2 0.38 9.87 0.36 1.69e-21 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs6987853 0.761 rs2974322 chr8:42424724 T/C cg09913449 chr8:42400586 C8orf40 0.42 9.34 0.35 1.62e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs11098499 0.863 rs1480936 chr4:120462861 C/T cg09307838 chr4:120376055 NA 0.7 14.09 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs4891159 1.000 rs4891159 chr18:74101941 A/G cg24786174 chr18:74118243 ZNF516 0.66 17.42 0.57 6.68e-56 Longevity; BRCA cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg12219531 chr12:120966889 COQ5 0.55 11.44 0.41 1.11e-27 High light scatter reticulocyte count; BRCA cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg18016565 chr1:150552671 MCL1 0.34 7.98 0.3 6.59e-15 Tonsillectomy; BRCA cis rs311392 0.902 rs2666874 chr8:55091561 A/T cg11783602 chr8:55087084 NA 0.31 8.8 0.33 1.25e-17 Pelvic organ prolapse (moderate/severe); BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg25036284 chr2:26402008 FAM59B 0.94 15.92 0.53 2.57e-48 Gut microbiome composition (summer); BRCA cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg20701182 chr2:24300061 SF3B14 0.65 9.37 0.35 1.2e-19 Lymphocyte counts; BRCA cis rs7917772 0.503 rs7078435 chr10:104304766 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.39 0.59 5.86e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7575217 0.697 rs34429055 chr2:101703696 G/C cg23907051 chr2:101730305 TBC1D8 0.2 7.92 0.3 1.06e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg14829155 chr15:31115871 NA -0.43 -9.86 -0.36 1.96e-21 Huntington's disease progression; BRCA trans rs12517041 1.000 rs16892312 chr5:23279764 G/C ch.8.1293020R chr8:59333349 UBXN2B -0.45 -8.11 -0.31 2.68e-15 Calcium levels; BRCA cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.46e-31 Bipolar disorder; BRCA cis rs7402982 0.934 rs8028620 chr15:99202875 C/T cg03437748 chr15:99193247 IGF1R 0.71 17.63 0.57 5.23e-57 Birth weight; BRCA cis rs13046373 0.508 rs1012969 chr21:31996108 G/A cg24082983 chr21:31802169 KRTAP13-4 0.32 8.16 0.31 1.8e-15 HDL cholesterol; BRCA cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg18357645 chr12:58087776 OS9 -0.32 -7.99 -0.3 6.18e-15 Multiple sclerosis; BRCA cis rs7582180 0.764 rs1946799 chr2:100921136 C/A cg14675211 chr2:100938903 LONRF2 0.47 10.79 0.39 4.9e-25 Intelligence (multi-trait analysis); BRCA cis rs12431939 1.000 rs11850391 chr14:51639759 A/G cg23942311 chr14:51606299 NA -0.42 -8.26 -0.31 8.51e-16 Cancer; BRCA trans rs208515 0.525 rs10455593 chr6:66691341 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.05 0.54 5.75e-49 Exhaled nitric oxide levels; BRCA cis rs61990749 0.597 rs1006039 chr14:78263196 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.62 -9.8 -0.36 3.15e-21 Fibroblast growth factor basic levels; BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg12444411 chr7:2802554 GNA12 -0.34 -8.66 -0.32 3.81e-17 Height; BRCA cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg19847866 chr10:1019161 NA 0.51 10.67 0.39 1.39e-24 Response to angiotensin II receptor blocker therapy; BRCA cis rs27434 0.561 rs35134 chr5:96159523 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.95 -0.46 3.29e-34 Ankylosing spondylitis; BRCA cis rs7592578 0.581 rs59109438 chr2:191287683 A/G cg10560079 chr2:191398806 TMEM194B -0.65 -11.98 -0.43 5.89e-30 Diastolic blood pressure; BRCA cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg08807101 chr21:30365312 RNF160 -0.67 -16.92 -0.56 2.5e-53 Dental caries; BRCA cis rs1865721 0.682 rs7242637 chr18:73147492 A/C cg26385618 chr18:73139727 C18orf62 -0.38 -9.53 -0.35 3.1e-20 Intelligence; BRCA cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.82 0.45 1.21e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs9287719 0.781 rs6714413 chr2:10758859 C/T cg00105475 chr2:10696890 NA 0.42 9.61 0.36 1.65e-20 Prostate cancer; BRCA cis rs7945705 0.818 rs10769948 chr11:8761782 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -9.42 -0.35 8.12e-20 Hemoglobin concentration; BRCA cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg07636037 chr3:49044803 WDR6 0.91 23.57 0.68 7.57e-89 Parkinson's disease; BRCA cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg19717773 chr7:2847554 GNA12 -0.43 -9.65 -0.36 1.13e-20 Height; BRCA cis rs17270561 0.609 rs12192077 chr6:25732794 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA trans rs9784649 0.760 rs17343923 chr5:25052414 G/A cg08600765 chr20:34638493 LOC647979 -0.67 -11.09 -0.4 2.98e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.74 10.1 0.37 2.39e-22 Initial pursuit acceleration; BRCA cis rs7618915 0.547 rs12496476 chr3:52708737 A/G cg10802521 chr3:52805072 NEK4 -0.33 -8.51 -0.32 1.19e-16 Bipolar disorder; BRCA cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg24088639 chr11:34937564 PDHX;APIP -0.4 -9.04 -0.34 1.84e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.54 0.47 6.44e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72781680 0.898 rs7563564 chr2:23993404 T/C cg20701182 chr2:24300061 SF3B14 0.55 8.53 0.32 1.09e-16 Lymphocyte counts; BRCA cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg22764044 chr5:178986830 RUFY1 0.37 8.56 0.32 8.69e-17 Lung cancer; BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.21e-18 Tonsillectomy; BRCA cis rs9914988 0.887 rs11656272 chr17:27091153 A/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.82 -0.33 1.08e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs13108904 0.935 rs3755920 chr4:1243617 T/C cg05665937 chr4:1216051 CTBP1 0.42 8.74 0.33 2.04e-17 Obesity-related traits; BRCA cis rs7618501 0.633 rs2526751 chr3:50064867 T/C cg24308560 chr3:49941425 MST1R 0.4 8.56 0.32 8.14e-17 Intelligence (multi-trait analysis); BRCA cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs1997103 0.834 rs10274457 chr7:55390199 G/A cg17469321 chr7:55412551 NA 0.52 9.82 0.36 2.79e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs11098499 0.604 rs2389887 chr4:120570644 T/C cg09307838 chr4:120376055 NA 0.58 10.92 0.4 1.48e-25 Corneal astigmatism; BRCA trans rs11098499 1.000 rs11098499 chr4:120187611 C/T cg25214090 chr10:38739885 LOC399744 0.49 10.87 0.4 2.22e-25 Corneal astigmatism; BRCA cis rs9467773 0.549 rs9467805 chr6:26583366 C/T cg11502198 chr6:26597334 ABT1 0.58 12.48 0.44 4.02e-32 Intelligence (multi-trait analysis); BRCA trans rs6479891 0.915 rs9415699 chr10:65143558 C/T cg14819942 chr15:35414228 NA -0.34 -8.53 -0.32 1.09e-16 Arthritis (juvenile idiopathic); BRCA cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg01689657 chr7:91764605 CYP51A1 0.21 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg17366294 chr4:99064904 C4orf37 0.43 9.79 0.36 3.63e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg11764359 chr7:65958608 NA -0.78 -18.2 -0.58 5.75e-60 Aortic root size; BRCA cis rs2204008 0.837 rs11168387 chr12:37962818 G/A cg26384229 chr12:38710491 ALG10B -0.57 -13.45 -0.47 1.77e-36 Bladder cancer; BRCA cis rs4474465 0.688 rs4277140 chr11:78285096 G/T cg27205649 chr11:78285834 NARS2 -0.41 -14.13 -0.49 1.21e-39 Alzheimer's disease (survival time); BRCA cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs8072100 0.790 rs6505048 chr17:45674998 G/A cg19784903 chr17:45786737 TBKBP1 0.35 8.46 0.32 1.88e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.06 -23.45 -0.68 3.31e-88 Gut microbiome composition (summer); BRCA cis rs6964587 0.967 rs17164315 chr7:91659150 C/G cg17063962 chr7:91808500 NA 0.53 12.58 0.45 1.43e-32 Breast cancer; BRCA cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg06697600 chr4:7070879 GRPEL1 -0.66 -12.99 -0.46 2.19e-34 Monocyte percentage of white cells; BRCA cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg21475434 chr5:93447410 FAM172A 0.66 8.6 0.32 5.95e-17 Diabetic retinopathy; BRCA cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg20818283 chr2:191399100 TMEM194B 0.41 9.39 0.35 1.01e-19 Pulse pressure; BRCA cis rs17376456 0.825 rs28645862 chr5:93233128 G/C cg21475434 chr5:93447410 FAM172A 0.67 8.62 0.32 5.45e-17 Diabetic retinopathy; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg14004847 chr7:1930337 MAD1L1 -0.43 -8.41 -0.32 2.62e-16 Bipolar disorder and schizophrenia; BRCA cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.5e-64 Cognitive function; BRCA cis rs2072499 0.750 rs10159384 chr1:156160822 C/T cg25208724 chr1:156163844 SLC25A44 0.89 18.06 0.58 3.34e-59 Testicular germ cell tumor; BRCA cis rs9487051 0.676 rs13211313 chr6:109562074 G/C cg01475377 chr6:109611718 NA -0.37 -8.87 -0.33 7.04e-18 Reticulocyte fraction of red cells; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26314531 chr2:26401878 FAM59B 0.9 16.15 0.54 1.92e-49 Gut microbiome composition (summer); BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.2 0.43 6.34e-31 Platelet count; BRCA cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg09021430 chr5:549028 NA -0.69 -14.55 -0.5 1.3e-41 Lung disease severity in cystic fibrosis; BRCA cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg05342945 chr12:48394962 COL2A1 0.49 10.08 0.37 2.86e-22 Lung cancer; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg09177884 chr7:1199841 ZFAND2A -0.46 -10.74 -0.39 7.3e-25 Longevity;Endometriosis; BRCA cis rs56104184 0.775 rs56349331 chr19:49403009 T/A cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs9814567 0.806 rs6799543 chr3:134216139 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.65 -0.61 1.36e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2011503 1.000 rs75525243 chr19:19638218 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 8.85e-19 Bipolar disorder; BRCA cis rs7666738 0.830 rs11735193 chr4:98761900 C/T cg05340658 chr4:99064831 C4orf37 0.63 15.11 0.51 2.45e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg02297831 chr4:17616191 MED28 0.39 8.64 0.32 4.47e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg00071950 chr4:10020882 SLC2A9 0.63 15.51 0.52 2.82e-46 Bone mineral density; BRCA cis rs13191362 1.000 rs13204439 chr6:163015358 A/C cg14584255 chr6:163149320 PACRG;PARK2 -0.46 -8.4 -0.32 2.93e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg24110177 chr3:50126178 RBM5 0.52 15.68 0.53 4e-47 Body mass index; BRCA cis rs3784262 0.512 rs4646572 chr15:58343021 T/C cg12031962 chr15:58353849 ALDH1A2 -0.49 -12.41 -0.44 7.74e-32 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs208515 0.525 rs12204452 chr6:66680325 C/T cg07460842 chr6:66804631 NA 0.87 15.64 0.53 6.69e-47 Exhaled nitric oxide levels; BRCA cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.45 9.54 0.35 2.95e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs12477438 0.822 rs6727170 chr2:99588042 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -12.09 -0.43 1.9e-30 Chronic sinus infection; BRCA cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.62 -11.8 -0.42 3.17e-29 Chronic sinus infection; BRCA cis rs1395 0.744 rs57881048 chr2:27474165 T/C cg23587288 chr2:27483067 SLC30A3 -0.38 -8.9 -0.33 5.91e-18 Blood metabolite levels; BRCA cis rs1949733 1.000 rs2688223 chr4:8471398 T/C cg13073564 chr4:8508604 NA -0.41 -10.89 -0.4 1.85e-25 Response to antineoplastic agents; BRCA cis rs11249608 0.750 rs6891216 chr5:178447026 G/C cg21905437 chr5:178450457 ZNF879 0.5 10.32 0.38 3.31e-23 Pubertal anthropometrics; BRCA trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg15556689 chr8:8085844 FLJ10661 -0.4 -10.64 -0.39 1.93e-24 Triglycerides; BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg04518342 chr5:131593106 PDLIM4 0.35 8.84 0.33 9.23e-18 Breast cancer; BRCA cis rs6121246 0.697 rs6088856 chr20:30226543 C/G cg13852791 chr20:30311386 BCL2L1 0.76 13.85 0.48 2.57e-38 Mean corpuscular hemoglobin; BRCA cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg00012203 chr2:219082015 ARPC2 -0.48 -9.33 -0.35 1.78e-19 Colorectal cancer; BRCA cis rs7829975 0.606 rs10112585 chr8:8795030 A/T cg15556689 chr8:8085844 FLJ10661 -0.41 -11.44 -0.41 1.09e-27 Mood instability; BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.29 -0.41 4.29e-27 Gut microbiome composition (summer); BRCA cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs3768617 0.510 rs7525917 chr1:183065406 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.19 0.54 1.15e-49 Fuchs's corneal dystrophy; BRCA trans rs4819388 0.915 rs6518352 chr21:45646698 A/G cg17383793 chr5:52405638 MOCS2 0.5 11.22 0.41 8.78e-27 Celiac disease; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg10729496 chr3:10149963 C3orf24 0.49 9.34 0.35 1.5700000000000001e-19 Alzheimer's disease; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 13.94 0.48 9.37e-39 Alzheimer's disease; BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 23.03 0.67 6.4e-86 Platelet count; BRCA cis rs11955398 0.716 rs3857236 chr5:59909529 G/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.38 0.35 1.14e-19 Intelligence (multi-trait analysis); BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg08742575 chr21:47604166 C21orf56 -0.42 -8.13 -0.31 2.2e-15 Testicular germ cell tumor; BRCA cis rs727479 0.502 rs2899471 chr15:51506553 G/A cg19946085 chr15:51559439 CYP19A1 -0.31 -8.62 -0.32 5.16e-17 Estradiol levels; BRCA cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg04455712 chr21:45112962 RRP1B 0.44 11.39 0.41 1.71e-27 Mean corpuscular volume; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg18402987 chr7:1209562 NA 0.87 12.28 0.44 2.89e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10191773 0.589 rs72833410 chr2:113054119 G/A cg24977338 chr2:113188963 RGPD8;RGPD5 -0.57 -8.16 -0.31 1.74e-15 Yeast infection; BRCA cis rs2645694 0.626 rs2703122 chr4:77821418 A/C cg03477792 chr4:77819574 ANKRD56 0.66 15.67 0.53 4.35e-47 Emphysema distribution in smoking; BRCA cis rs6062302 0.522 rs2297428 chr20:62221766 C/T cg16989086 chr20:62203971 PRIC285 0.53 8.89 0.33 6.05e-18 Glioblastoma; BRCA cis rs7520050 0.966 rs10789487 chr1:46420221 G/A cg24296786 chr1:45957014 TESK2 0.44 9.76 0.36 4.47e-21 Red blood cell count;Reticulocyte count; BRCA cis rs11112613 0.713 rs11112588 chr12:105943801 A/C cg03607813 chr12:105948248 NA 0.6 11.05 0.4 4.14e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs4808199 1.000 rs60003758 chr19:19557353 A/G cg03709012 chr19:19516395 GATAD2A 1.08 21.19 0.64 7.13e-76 Nonalcoholic fatty liver disease; BRCA cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg08085267 chr17:45401833 C17orf57 -0.67 -14.99 -0.51 9.2e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs16976116 0.901 rs1050931 chr15:55497691 G/A cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11249608 0.548 rs6880315 chr5:178452502 G/A cg21905437 chr5:178450457 ZNF879 0.52 10.74 0.39 7.62e-25 Pubertal anthropometrics; BRCA cis rs3760982 0.585 rs11673534 chr19:44298884 G/A cg12072164 chr19:44306565 LYPD5 0.37 8.71 0.33 2.57e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs758324 1.000 rs758324 chr5:131109545 G/T cg06307176 chr5:131281290 NA 0.53 10.21 0.37 8.75e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg16339924 chr4:17578868 LAP3 0.63 15.93 0.53 2.26e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg12386194 chr3:101231763 SENP7 0.45 9.6 0.36 1.75e-20 Colorectal cancer; BRCA cis rs35110281 0.774 rs162344 chr21:44954522 G/A cg04455712 chr21:45112962 RRP1B 0.4 10.51 0.38 6e-24 Mean corpuscular volume; BRCA cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg25319279 chr11:5960081 NA -0.41 -7.91 -0.3 1.17e-14 DNA methylation (variation); BRCA cis rs11779988 0.545 rs4124900 chr8:17785266 A/G cg01800426 chr8:17659068 MTUS1 -0.4 -8.4 -0.32 2.97e-16 Breast cancer; BRCA cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.38 0.38 2.03e-23 Motion sickness; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg16606324 chr3:10149918 C3orf24 0.56 9.97 0.37 7.35e-22 Alzheimer's disease; BRCA cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg17971929 chr21:40555470 PSMG1 -0.61 -13.92 -0.48 1.19e-38 Cognitive function; BRCA cis rs12022452 0.591 rs12042242 chr1:40993873 A/G cg25568243 chr1:40974465 DEM1 -0.49 -9.06 -0.34 1.57e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg00409905 chr10:38381863 ZNF37A -0.5 -10.44 -0.38 1.14e-23 Extrinsic epigenetic age acceleration; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg02261765 chr11:831170 EFCAB4A -0.4 -8.68 -0.32 3.35e-17 Mean platelet volume; BRCA cis rs9837602 1.000 rs17379739 chr3:99724792 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.6 0.39 2.71e-24 Breast cancer; BRCA cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg12386194 chr3:101231763 SENP7 0.46 9.66 0.36 1.03e-20 Colorectal cancer; BRCA cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -16.92 -0.56 2.46e-53 Extrinsic epigenetic age acceleration; BRCA cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.33 0.61 6.67e-66 Smoking behavior; BRCA cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.32 0.38 3.47e-23 Mean platelet volume; BRCA cis rs7618915 0.571 rs12632381 chr3:52607685 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.33 -0.31 5.11e-16 Bipolar disorder; BRCA cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg13298116 chr11:62369859 EML3;MTA2 0.55 13.06 0.46 1.06e-34 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs8010715 1.000 rs3742500 chr14:24611978 G/T cg23112188 chr14:24563095 PCK2 -0.34 -8.37 -0.31 3.69e-16 IgG glycosylation; BRCA cis rs11809207 0.523 rs2783707 chr1:26504196 C/G cg23602478 chr1:26503979 CNKSR1 0.23 7.84 0.3 1.91e-14 Height; BRCA cis rs78707713 0.512 rs12772559 chr10:71184356 C/G cg12610070 chr10:71211762 TSPAN15 -0.32 -10.43 -0.38 1.27e-23 Venous thromboembolism; BRCA cis rs6878727 0.613 rs319627 chr5:123674793 G/T cg01806427 chr5:123737813 NA -0.36 -8.15 -0.31 1.97e-15 Breast cancer; BRCA cis rs7178424 0.935 rs3784633 chr15:62259772 C/T cg00456672 chr15:62358751 C2CD4A 0.35 8.05 0.3 4.12e-15 Height; BRCA cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg26031613 chr14:104095156 KLC1 -0.45 -8.9 -0.33 5.62e-18 Schizophrenia; BRCA cis rs6963495 0.519 rs3892297 chr7:105152173 G/A cg13798780 chr7:105162888 PUS7 0.45 7.9 0.3 1.21e-14 Bipolar disorder (body mass index interaction); BRCA trans rs7786808 0.615 rs4909212 chr7:158197037 G/T cg02030672 chr11:45687055 CHST1 0.51 11.45 0.41 9.7e-28 Obesity-related traits; BRCA cis rs1046896 1.000 rs1046875 chr17:80685426 A/G cg02711726 chr17:80685570 FN3KRP 0.68 16.5 0.55 3.31e-51 Glycated hemoglobin levels; BRCA cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg24209194 chr3:40518798 ZNF619 -0.39 -7.92 -0.3 1.07e-14 Renal cell carcinoma; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg24642844 chr7:1081250 C7orf50 -0.89 -16.29 -0.54 3.52e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg24642439 chr20:33292090 TP53INP2 0.69 15.78 0.53 1.3e-47 Coronary artery disease; BRCA cis rs3858526 0.916 rs11039551 chr11:5930773 C/T cg02574844 chr11:5959923 NA -0.44 -8.6 -0.32 5.91e-17 DNA methylation (variation); BRCA trans rs17685 0.712 rs1639620 chr7:75704090 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 28.25 0.75 1.44e-114 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs7980799 0.935 rs12301124 chr12:33543024 T/C cg26384229 chr12:38710491 ALG10B -0.39 -7.98 -0.3 6.59e-15 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.5 9.71 0.36 6.73e-21 Lung cancer in ever smokers; BRCA cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.22 0.49 4.65e-40 Motion sickness; BRCA cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 11.29 0.41 4.61e-27 Personality dimensions; BRCA cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg00071950 chr4:10020882 SLC2A9 0.63 15.51 0.52 2.82e-46 Bone mineral density; BRCA trans rs17685 0.753 rs869806 chr7:75688623 C/T cg19862616 chr7:65841803 NCRNA00174 0.84 28.29 0.75 9.34e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7927771 1.000 rs34910028 chr11:47758449 T/C cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs701145 0.585 rs357466 chr3:153902868 A/G cg17054900 chr3:154042577 DHX36 0.53 9.34 0.35 1.62e-19 Coronary artery disease; BRCA cis rs807669 0.548 rs5746685 chr22:19192596 C/G cg02655711 chr22:19163373 SLC25A1 -0.66 -15.96 -0.53 1.57e-48 Metabolite levels; BRCA cis rs7824557 0.806 rs7007394 chr8:11094566 G/A cg21775007 chr8:11205619 TDH -0.47 -9.37 -0.35 1.26e-19 Retinal vascular caliber; BRCA trans rs2832077 0.943 rs2832099 chr21:30173460 A/G cg14791747 chr16:20752902 THUMPD1 0.43 10.46 0.38 9.47e-24 Cognitive test performance; BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg26119090 chr2:26468346 HADHA;HADHB 0.81 12.38 0.44 1.05e-31 Gut microbiome composition (summer); BRCA cis rs3806843 1.000 rs2240695 chr5:140168151 G/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.77 -0.36 4.22e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs477692 0.905 rs576560 chr10:131420697 C/A cg24747557 chr10:131355152 MGMT -0.31 -7.85 -0.3 1.76e-14 Response to temozolomide; BRCA cis rs12367572 0.965 rs10880696 chr12:45234989 A/G cg04608330 chr12:45269318 NELL2 0.57 12.51 0.44 2.72e-32 Gut microbiome composition (summer); BRCA cis rs7914558 0.966 rs3758543 chr10:104944744 C/G cg04362960 chr10:104952993 NT5C2 0.43 10.25 0.38 6.42e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg25358565 chr5:93447407 FAM172A 1.21 19.75 0.62 3.88e-68 Diabetic retinopathy; BRCA cis rs2859741 0.967 rs592520 chr1:37513503 G/C cg09363841 chr1:37513479 NA -0.71 -18.5 -0.59 1.62e-61 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg08888203 chr3:10149979 C3orf24 0.68 14.48 0.5 2.55e-41 Alzheimer's disease; BRCA cis rs6121246 0.738 rs2376996 chr20:30316667 T/A cg21427119 chr20:30132790 HM13 -0.42 -8.79 -0.33 1.38e-17 Mean corpuscular hemoglobin; BRCA cis rs7809950 1.000 rs2237677 chr7:107202502 A/C cg23024343 chr7:107201750 COG5 -0.38 -8.86 -0.33 7.64e-18 Coronary artery disease; BRCA cis rs6815814 0.904 rs3924113 chr4:38796255 G/T cg06935464 chr4:38784597 TLR10 0.5 8.04 0.3 4.37e-15 Breast cancer; BRCA cis rs2625529 0.586 rs7175197 chr15:72461648 G/A cg16672083 chr15:72433130 SENP8 0.66 16.16 0.54 1.62e-49 Red blood cell count; BRCA cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg18876405 chr7:65276391 NA -0.5 -11.37 -0.41 2.06e-27 Aortic root size; BRCA cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.39 -9.55 -0.35 2.83e-20 Personality dimensions; BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs887829 0.570 rs12623271 chr2:234599941 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.49 -0.32 1.44e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg09184832 chr6:79620586 NA -0.5 -11.17 -0.4 1.34e-26 Intelligence (multi-trait analysis); BRCA cis rs6450176 1.000 rs67473746 chr5:53296730 G/C ch.5.1024479R chr5:53302184 ARL15 -0.63 -14.96 -0.51 1.31e-43 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg21573476 chr21:45109991 RRP1B -0.35 -9.18 -0.34 6.06e-19 Mean corpuscular volume; BRCA cis rs7246967 0.673 rs59621958 chr19:22940659 C/T cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA trans rs208520 0.661 rs7766144 chr6:66827795 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.65 -0.63 5.57e-73 Exhaled nitric oxide output; BRCA cis rs11190604 0.697 rs4559619 chr10:102199884 C/T cg07080220 chr10:102295463 HIF1AN -0.44 -10.09 -0.37 2.5e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg26818010 chr10:134567672 INPP5A -0.72 -15.22 -0.52 7.23e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 16.45 0.55 5.54e-51 Colorectal cancer; BRCA cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg10556349 chr10:835070 NA 0.64 8.74 0.33 1.98e-17 Eosinophil percentage of granulocytes; BRCA cis rs4319547 0.698 rs10773178 chr12:122944752 T/C cg23029597 chr12:123009494 RSRC2 -0.46 -9.34 -0.35 1.58e-19 Body mass index; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg16145915 chr7:1198662 ZFAND2A -0.45 -10.72 -0.39 8.66e-25 Longevity;Endometriosis; BRCA cis rs2549003 1.000 rs2070726 chr5:131821738 C/A cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA cis rs7666738 0.791 rs13146909 chr4:98934198 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg18876405 chr7:65276391 NA -0.52 -12.53 -0.44 2.3e-32 Aortic root size; BRCA cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg22875332 chr1:76189707 ACADM -0.78 -21.35 -0.65 9.97e-77 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs60843830 0.623 rs55932737 chr2:107543 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.48 9.36 0.35 1.35e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6060960 0.537 rs75351461 chr20:30458612 C/T cg13852791 chr20:30311386 BCL2L1 0.56 8.04 0.3 4.4e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg13852791 chr20:30311386 BCL2L1 0.83 15.48 0.52 3.93e-46 Mean corpuscular hemoglobin; BRCA cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.32 -0.31 5.32e-16 Bipolar disorder; BRCA cis rs9814567 1.000 rs1863913 chr3:134200205 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -9.27 -0.34 2.84e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.865 rs28634456 chr4:120375778 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.59 0.45 1.26e-32 Corneal astigmatism; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg23978390 chr7:1156363 C7orf50 0.41 9.92 0.37 1.14e-21 Longevity;Endometriosis; BRCA trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.64 0.55 6.52e-52 Morning vs. evening chronotype; BRCA cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg04511125 chr2:88470314 THNSL2 0.94 13.18 0.46 2.99e-35 Plasma clusterin levels; BRCA cis rs614226 1.000 rs7174 chr12:121017171 A/G cg27489772 chr12:121021490 NA 0.45 8.03 0.3 4.74e-15 Type 1 diabetes nephropathy; BRCA cis rs2243480 1.000 rs4718270 chr7:65202407 A/G cg18252515 chr7:66147081 NA -0.9 -12.93 -0.46 3.87e-34 Diabetic kidney disease; BRCA cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.43 -0.35 7.23e-20 Body mass index; BRCA cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg26384229 chr12:38710491 ALG10B 0.78 17.49 0.57 2.99e-56 Morning vs. evening chronotype; BRCA cis rs7584330 0.744 rs10929235 chr2:238380272 A/G cg14458575 chr2:238380390 NA 0.77 17.31 0.56 2.59e-55 Prostate cancer; BRCA cis rs2766692 1.000 rs2766690 chr14:100682154 A/G cg14866419 chr14:100704911 YY1 -0.43 -8.87 -0.33 7.23e-18 Electroencephalographic traits in alcoholism; BRCA cis rs3857536 0.740 rs7766407 chr6:66885658 C/A cg07460842 chr6:66804631 NA -0.48 -9.27 -0.34 2.78e-19 Blood trace element (Cu levels); BRCA cis rs9359856 0.510 rs2748298 chr6:90436877 A/C cg13799429 chr6:90582589 CASP8AP2 -0.71 -10.78 -0.39 5.12e-25 Bipolar disorder; BRCA cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.89 0.36 1.54e-21 Lung cancer in ever smokers; BRCA trans rs61931739 0.517 rs11513277 chr12:34074799 G/T cg13010199 chr12:38710504 ALG10B 0.49 9.38 0.35 1.15e-19 Morning vs. evening chronotype; BRCA cis rs16958440 0.867 rs76922914 chr18:44688454 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.46e-37 Sitting height ratio; BRCA cis rs7267979 1.000 rs2027003 chr20:25350498 A/G cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2243480 1.000 rs186378 chr7:65582058 A/C cg18252515 chr7:66147081 NA -1.05 -15.27 -0.52 4.18e-45 Diabetic kidney disease; BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg23708337 chr7:1209742 NA 0.48 8.06 0.3 3.76e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4713118 0.586 rs9468290 chr6:28087674 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Parkinson's disease; BRCA cis rs701145 0.556 rs355756 chr3:154021063 G/A cg12800244 chr3:153838788 SGEF 0.44 8.9 0.33 5.58e-18 Coronary artery disease; BRCA cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg00825309 chr19:58991885 ZNF446 -0.58 -12.78 -0.45 1.83e-33 Uric acid clearance; BRCA cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg21535247 chr6:8435926 SLC35B3 0.41 9.4 0.35 9.75e-20 Motion sickness; BRCA cis rs113835537 0.529 rs11227514 chr11:66286627 G/A cg24851651 chr11:66362959 CCS 0.42 8.01 0.3 5.37e-15 Airway imaging phenotypes; BRCA trans rs11098499 0.863 rs13136462 chr4:120543173 C/T cg25214090 chr10:38739885 LOC399744 0.54 11.76 0.42 4.92e-29 Corneal astigmatism; BRCA cis rs7568458 0.846 rs2028900 chr2:85767735 A/G cg02493740 chr2:85810744 VAMP5 0.37 7.93 0.3 9.98e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg16606324 chr3:10149918 C3orf24 0.49 9.94 0.37 9.21e-22 Alzheimer's disease; BRCA cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.29 0.38 4.41e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4561483 0.801 rs33619 chr16:12008941 T/G cg08843971 chr16:11963173 GSPT1 -0.52 -11.84 -0.42 2.21e-29 Testicular germ cell tumor; BRCA cis rs9325144 0.602 rs11169100 chr12:39077861 G/T cg26384229 chr12:38710491 ALG10B -0.47 -10.87 -0.39 2.36e-25 Morning vs. evening chronotype; BRCA cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.72 -0.36 6.56e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7524258 0.868 rs7544314 chr1:7266744 G/C cg07173049 chr1:7289937 CAMTA1 0.53 12.93 0.46 3.98e-34 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.79 0.39 4.76e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs367943 0.644 rs348942 chr5:112824039 T/C cg12552261 chr5:112820674 MCC -0.57 -12.42 -0.44 7.14e-32 Type 2 diabetes; BRCA trans rs7613875 0.620 rs7634441 chr3:50071677 G/A cg21659725 chr3:3221576 CRBN -0.35 -8.52 -0.32 1.18e-16 Body mass index; BRCA cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg16325326 chr1:53192061 ZYG11B 0.69 17.17 0.56 1.36e-54 Monocyte count; BRCA cis rs9308433 0.529 rs11800749 chr1:214499754 A/G cg06198575 chr1:214491504 SMYD2 -0.52 -11.74 -0.42 6.08e-29 IgG glycosylation; BRCA cis rs7301826 0.932 rs1007246 chr12:131280130 T/A cg11011512 chr12:131303247 STX2 0.42 10.74 0.39 7.35e-25 Plasma plasminogen activator levels; BRCA cis rs7904368 0.754 rs7091240 chr10:16855683 G/A cg14835575 chr10:16859367 RSU1 0.63 12.92 0.46 4.45e-34 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 14.17 0.49 8.02e-40 Colorectal cancer; BRCA cis rs17401966 0.858 rs61778404 chr1:10432879 A/G cg19773385 chr1:10388646 KIF1B -0.38 -8.23 -0.31 1.06e-15 Hepatocellular carcinoma; BRCA cis rs9487051 0.646 rs11153167 chr6:109622582 A/T cg01475377 chr6:109611718 NA 0.41 8.94 0.33 4.3e-18 Reticulocyte fraction of red cells; BRCA trans rs1974653 0.813 rs9606232 chr22:20065370 C/T cg20152630 chr19:46405944 MYPOP 0.39 8.5 0.32 1.36e-16 Schizophrenia; BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00908189 chr16:619842 PIGQ 0.67 16.74 0.55 2.04e-52 Height; BRCA cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg11742103 chr11:62369870 EML3;MTA2 0.52 13.23 0.46 1.77e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.53 12.09 0.43 1.93e-30 Colorectal cancer; BRCA cis rs9467711 0.591 rs13214280 chr6:26008620 C/T cg21479132 chr6:26055353 NA 0.57 8.02 0.3 4.93e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg23719950 chr11:63933701 MACROD1 -0.58 -9.82 -0.36 2.74e-21 Mean platelet volume; BRCA cis rs2180341 0.711 rs4371861 chr6:127568447 G/T cg24812749 chr6:127587940 RNF146 0.54 12.06 0.43 2.66e-30 Breast cancer; BRCA cis rs1997103 1.000 rs4948011 chr7:55403859 A/G cg17469321 chr7:55412551 NA 0.48 9.11 0.34 1.05e-18 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7408868 0.764 rs62113791 chr19:15277009 C/T cg14696996 chr19:15285081 NOTCH3 0.99 14.49 0.5 2.35e-41 Pulse pressure; BRCA cis rs7727544 0.548 rs2069614 chr5:131407601 T/C cg14196790 chr5:131705035 SLC22A5 0.35 8.77 0.33 1.61e-17 Blood metabolite levels; BRCA cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg05623727 chr3:50126028 RBM5 0.41 9.7 0.36 7.31e-21 Intelligence (multi-trait analysis); BRCA trans rs6600671 0.899 rs6674392 chr1:121260662 C/G cg00646200 chr1:148855367 NA 0.32 8.25 0.31 9.14e-16 Hip geometry; BRCA trans rs11227306 0.902 rs625652 chr11:65641931 T/A cg17712092 chr4:129076599 LARP1B -0.38 -8.06 -0.3 3.63e-15 DNA methylation (variation); BRCA trans rs35110281 0.626 rs10854486 chr21:45118280 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.51 0.32 1.28e-16 Mean corpuscular volume; BRCA cis rs11920090 0.858 rs6808595 chr3:170674678 A/G cg09710316 chr3:170744871 SLC2A2 0.55 9.24 0.34 3.56e-19 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs9287719 0.967 rs7582775 chr2:10738449 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs9807989 0.524 rs6759479 chr2:103040047 A/C cg03938978 chr2:103052716 IL18RAP 0.29 8.3 0.31 6.11e-16 Asthma; BRCA cis rs6750047 0.546 rs10192788 chr2:38272672 C/T cg07380506 chr2:38303506 CYP1B1 0.48 10.62 0.39 2.19e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.505 rs1208689 chr10:38097775 C/G cg17830980 chr10:43048298 ZNF37B -0.41 -9.65 -0.36 1.12e-20 Extrinsic epigenetic age acceleration; BRCA cis rs7918232 0.830 rs7087033 chr10:27392522 A/G cg14240646 chr10:27532245 ACBD5 -0.6 -9.06 -0.34 1.53e-18 Breast cancer; BRCA cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.55 -0.32 8.79e-17 Developmental language disorder (linguistic errors); BRCA cis rs2760061 0.626 rs596208 chr1:228117982 G/C cg02753203 chr1:228287806 NA -0.6 -12.87 -0.45 7.2e-34 Diastolic blood pressure; BRCA cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg12310025 chr6:25882481 NA 0.43 9.51 0.35 3.69e-20 Intelligence (multi-trait analysis); BRCA cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg02079420 chr8:82753780 SNX16 -0.32 -8.64 -0.32 4.33e-17 Diastolic blood pressure; BRCA cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg13319975 chr6:146136371 FBXO30 0.43 10.04 0.37 4.06e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg13628971 chr7:2884303 GNA12 0.47 9.64 0.36 1.3e-20 Height; BRCA cis rs1568889 0.838 rs7125749 chr11:28154692 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 20.72 0.63 2.49e-73 Bipolar disorder; BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs78456975 0.739 rs11896906 chr2:1519550 A/G cg12573674 chr2:1569213 NA -0.48 -9.48 -0.35 4.9e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9457247 0.765 rs9457252 chr6:167433925 A/G cg23791538 chr6:167370224 RNASET2 0.39 9.2 0.34 4.95e-19 Crohn's disease; BRCA cis rs1153858 0.621 rs1719237 chr15:45579822 G/A cg14582100 chr15:45693742 SPATA5L1 0.29 8.53 0.32 1.08e-16 Homoarginine levels; BRCA cis rs12760731 0.720 rs16852717 chr1:178309723 T/C cg00404053 chr1:178313656 RASAL2 0.62 8.57 0.32 7.67e-17 Obesity-related traits; BRCA cis rs9309473 0.583 rs6713196 chr2:73576405 T/C cg20560298 chr2:73613845 ALMS1 -0.44 -11.57 -0.42 3.11e-28 Metabolite levels; BRCA cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14019695 chr9:139328340 INPP5E -0.37 -10.25 -0.38 6.24e-23 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9467773 1.000 rs6924838 chr6:26571756 C/T cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.53e-57 Intelligence (multi-trait analysis); BRCA cis rs7561273 0.586 rs13418279 chr2:24349218 G/T cg04809136 chr2:24300158 SF3B14 -0.4 -8.94 -0.33 4.13e-18 Quantitative traits; BRCA cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg02574844 chr11:5959923 NA -0.43 -8.46 -0.32 1.76e-16 DNA methylation (variation); BRCA cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg02734326 chr4:10020555 SLC2A9 0.41 8.99 0.34 2.74e-18 Bone mineral density; BRCA cis rs16958440 1.000 rs62096470 chr18:44641466 G/C cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs7246657 0.943 rs7253091 chr19:37967214 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.65 0.36 1.19e-20 Coronary artery calcification; BRCA cis rs7647973 0.516 rs4499638 chr3:49202782 C/G cg07636037 chr3:49044803 WDR6 0.82 21.71 0.65 9.9e-79 Menarche (age at onset); BRCA cis rs2599510 0.934 rs2710634 chr2:32808804 T/C cg02381751 chr2:32503542 YIPF4 0.43 8.74 0.33 2.12e-17 Interleukin-18 levels; BRCA trans rs877282 1.000 rs10904552 chr10:774326 A/G cg22713356 chr15:30763199 NA 1.18 24.01 0.69 2.83e-91 Uric acid levels; BRCA cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg18225595 chr11:63971243 STIP1 0.5 8.89 0.33 6.45e-18 Mean platelet volume; BRCA cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg08508325 chr11:3079039 CARS 0.29 8.54 0.32 1.02e-16 Calcium levels; BRCA cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg04553112 chr3:125709451 NA -0.53 -8.69 -0.32 3.12e-17 Blood pressure (smoking interaction); BRCA trans rs208520 0.526 rs4710310 chr6:66802808 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.09 -35.75 -0.82 1.44e-154 Exhaled nitric oxide output; BRCA cis rs11098499 0.863 rs36040693 chr4:120477616 A/G cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg19784903 chr17:45786737 TBKBP1 0.34 8.13 0.31 2.17e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1710278 0.967 rs1278264 chr10:127746893 G/A cg22975853 chr10:127789788 ADAM12 0.3 7.88 0.3 1.37e-14 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs4561483 0.645 rs2192645 chr16:11928019 C/T cg08843971 chr16:11963173 GSPT1 -0.44 -9.85 -0.36 2.14e-21 Testicular germ cell tumor; BRCA cis rs2505998 0.833 rs2251674 chr10:43605392 A/G cg15436174 chr10:43711423 RASGEF1A 0.39 8.0 0.3 5.89e-15 Hirschsprung disease; BRCA cis rs1153858 1.000 rs11070457 chr15:45686943 A/C cg21132104 chr15:45694354 SPATA5L1 0.74 16.31 0.54 2.91e-50 Homoarginine levels; BRCA cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06544989 chr22:39130855 UNC84B 0.38 8.74 0.33 2.04e-17 Menopause (age at onset); BRCA cis rs4077515 0.870 rs11793497 chr9:139271850 A/G cg14019695 chr9:139328340 INPP5E 0.32 8.13 0.31 2.28e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg13319975 chr6:146136371 FBXO30 0.62 14.44 0.5 4.22e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg24829409 chr8:58192753 C8orf71 -0.5 -10.23 -0.38 7.43e-23 Developmental language disorder (linguistic errors); BRCA cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg08999081 chr20:33150536 PIGU -0.46 -12.54 -0.44 2e-32 Glomerular filtration rate (creatinine); BRCA cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs6460942 0.915 rs62448621 chr7:12459941 G/A cg20607287 chr7:12443886 VWDE -0.58 -8.36 -0.31 3.96e-16 Coronary artery disease; BRCA cis rs1190552 0.846 rs1044503 chr14:102965996 A/G cg18135206 chr14:102964638 TECPR2 0.46 8.98 0.33 3.11e-18 Blood protein levels; BRCA trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.95 0.3 8.6e-15 Corneal astigmatism; BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18758796 chr5:131593413 PDLIM4 0.37 9.22 0.34 4.2e-19 Acylcarnitine levels; BRCA cis rs11098499 0.566 rs7664440 chr4:120578540 A/G cg09307838 chr4:120376055 NA 0.57 10.76 0.39 6.08e-25 Corneal astigmatism; BRCA cis rs473651 0.935 rs474478 chr2:239335473 C/T cg03560586 chr2:239334908 ASB1 -0.52 -11.48 -0.41 7.11e-28 Multiple system atrophy; BRCA cis rs66887589 0.616 rs1052633 chr4:120215314 A/G cg09307838 chr4:120376055 NA 0.46 9.53 0.35 3.14e-20 Diastolic blood pressure; BRCA cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg05347473 chr6:146136440 FBXO30 -0.42 -8.38 -0.31 3.44e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26314531 chr2:26401878 FAM59B 0.73 10.38 0.38 1.93e-23 Gut microbiome composition (summer); BRCA cis rs853679 0.517 rs9393898 chr6:28130376 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.87 0.3 1.56e-14 Depression; BRCA cis rs68170813 0.559 rs7794598 chr7:106826381 C/T cg02696742 chr7:106810147 HBP1 -0.54 -9.35 -0.35 1.51e-19 Coronary artery disease; BRCA trans rs12517041 1.000 rs10074124 chr5:23318235 T/G ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs7737355 1.000 rs6872972 chr5:130621533 C/T cg06307176 chr5:131281290 NA 0.45 8.68 0.32 3.29e-17 Life satisfaction; BRCA cis rs2070488 0.965 rs3762788 chr3:38493852 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.56 0.63 1.72e-72 Electrocardiographic conduction measures; BRCA cis rs1949733 0.655 rs2631736 chr4:8478421 C/G cg13073564 chr4:8508604 NA 0.38 10.34 0.38 2.83e-23 Response to antineoplastic agents; BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg27170947 chr2:26402098 FAM59B 0.97 17.09 0.56 3.41e-54 Gut microbiome composition (summer); BRCA cis rs1971762 0.583 rs12810378 chr12:54091838 G/T cg23533419 chr12:54090519 NA -0.33 -8.39 -0.31 3.12e-16 Height; BRCA cis rs7666738 0.830 rs10017557 chr4:98983969 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07343612 chr16:622815 PIGQ -0.67 -21.41 -0.65 4.64e-77 Height; BRCA cis rs698833 0.962 rs786409 chr2:44731344 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.3 0.38 3.87e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs3892630 0.529 rs35300319 chr19:33409948 G/A cg22980127 chr19:33182716 NUDT19 0.68 12.52 0.44 2.46e-32 Red blood cell traits; BRCA cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg24812749 chr6:127587940 RNF146 0.88 20.63 0.63 7.68e-73 Breast cancer; BRCA cis rs7727544 0.735 rs273913 chr5:131661156 A/G cg24060327 chr5:131705240 SLC22A5 -0.51 -10.56 -0.39 3.85e-24 Blood metabolite levels; BRCA cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg10978503 chr1:24200527 CNR2 0.52 13.91 0.48 1.24e-38 Immature fraction of reticulocytes; BRCA cis rs9443645 0.527 rs10943608 chr6:79674929 T/C cg18132916 chr6:79620363 NA -0.39 -8.02 -0.3 5.04e-15 Intelligence (multi-trait analysis); BRCA cis rs7267979 0.966 rs7270835 chr20:25435067 C/T cg08601574 chr20:25228251 PYGB 0.36 8.37 0.31 3.65e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4664304 0.620 rs2136977 chr2:160722850 C/T cg02280532 chr2:160761244 LY75 0.35 7.87 0.3 1.57e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs11997175 0.583 rs12680811 chr8:33778426 A/C ch.8.33884649F chr8:33765107 NA 0.38 9.12 0.34 9.64e-19 Body mass index; BRCA cis rs7264396 0.790 rs2425083 chr20:34300456 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.1 0.31 2.75e-15 Total cholesterol levels; BRCA cis rs312273 0.582 rs312267 chr12:41250565 A/G cg17827154 chr12:41323612 CNTN1 -0.34 -7.89 -0.3 1.31e-14 Bipolar disorder; BRCA cis rs11583043 0.918 rs11582211 chr1:101416871 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.56 0.35 2.44e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs1568889 0.838 rs7943538 chr11:28288955 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.74 18.04 0.58 4.25e-59 Bipolar disorder; BRCA cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg05623727 chr3:50126028 RBM5 0.43 10.08 0.37 2.74e-22 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg18964960 chr10:1102726 WDR37 0.6 8.04 0.3 4.44e-15 Eosinophil percentage of granulocytes; BRCA cis rs7647973 1.000 rs3870341 chr3:49584745 A/G cg06212747 chr3:49208901 KLHDC8B 0.42 7.86 0.3 1.63e-14 Menarche (age at onset); BRCA trans rs61931739 0.534 rs1608911 chr12:34010249 T/C cg13010199 chr12:38710504 ALG10B 0.47 9.03 0.34 2.04e-18 Morning vs. evening chronotype; BRCA cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg16102102 chr5:83017553 HAPLN1 -0.91 -18.11 -0.58 1.72e-59 Prostate cancer; BRCA cis rs10751667 0.560 rs7924794 chr11:962745 A/T ch.11.42038R chr11:967971 AP2A2 0.52 16.47 0.55 4.61e-51 Alzheimer's disease (late onset); BRCA cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg18876405 chr7:65276391 NA 0.71 18.48 0.59 1.96e-61 Aortic root size; BRCA cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg01849466 chr14:104193079 ZFYVE21 -0.51 -11.08 -0.4 3.21e-26 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs10089 1.000 rs72794392 chr5:127490061 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 14.3 0.49 1.97e-40 Ileal carcinoids; BRCA cis rs796364 0.906 rs281789 chr2:200780698 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.78 13.1 0.46 6.99e-35 Schizophrenia; BRCA cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.59 0.32 6.68e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs654950 0.934 rs662999 chr1:42001160 A/C cg06885757 chr1:42089581 HIVEP3 0.27 9.39 0.35 1.04e-19 Airway imaging phenotypes; BRCA cis rs4908768 0.501 rs6668508 chr1:8574118 C/T cg20416874 chr1:8611966 RERE -0.29 -8.3 -0.31 6.25e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA trans rs9325144 0.647 rs12830095 chr12:38864199 C/T cg23762105 chr12:34175262 ALG10 0.37 8.59 0.32 6.53e-17 Morning vs. evening chronotype; BRCA cis rs1451375 0.617 rs12671474 chr7:50591395 C/A cg18232548 chr7:50535776 DDC 0.44 9.36 0.35 1.33e-19 Malaria; BRCA cis rs9914988 0.943 rs12453504 chr17:27119524 C/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs8062405 0.964 rs9972768 chr16:28861734 A/C cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.79 0.6 4.88e-63 Tonsillectomy; BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg14004847 chr7:1930337 MAD1L1 -0.41 -8.69 -0.33 3.04e-17 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.03 -19.63 -0.61 1.69e-67 Platelet count; BRCA cis rs2495707 0.624 rs2489007 chr10:102422046 A/G cg24024056 chr10:102415556 NA 0.32 7.84 0.3 1.9e-14 Body mass index; BRCA cis rs1580019 0.534 rs13237495 chr7:32560687 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.01 27.66 0.74 2.49e-111 Cognitive ability; BRCA trans rs6582630 0.555 rs11613249 chr12:38519339 T/C cg06521331 chr12:34319734 NA -0.47 -8.74 -0.33 2e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs10256972 0.647 rs10233430 chr7:1051664 T/C cg00431813 chr7:1051703 C7orf50 -0.39 -11.47 -0.41 8.19e-28 Longevity;Endometriosis; BRCA cis rs9287719 0.934 rs4629131 chr2:10744159 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs812925 0.537 rs10865324 chr2:61621307 G/A cg15711740 chr2:61764176 XPO1 0.33 8.2 0.31 1.34e-15 Immature fraction of reticulocytes; BRCA cis rs1865721 0.804 rs7229401 chr18:73148127 T/G cg26385618 chr18:73139727 C18orf62 -0.44 -10.63 -0.39 2.1e-24 Intelligence; BRCA cis rs7659604 0.643 rs6839375 chr4:122663610 G/C cg19748678 chr4:122722346 EXOSC9 0.42 8.67 0.32 3.48e-17 Type 2 diabetes; BRCA cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg11663144 chr21:46675770 NA -0.61 -13.91 -0.48 1.22e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg05340658 chr4:99064831 C4orf37 0.63 15.11 0.51 2.45e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs1864400 0.690 rs2565200 chr10:43622933 A/G cg15436174 chr10:43711423 RASGEF1A -0.55 -11.03 -0.4 5.22e-26 Hirschsprung disease; BRCA trans rs6582630 0.634 rs10748443 chr12:38734062 G/T cg23762105 chr12:34175262 ALG10 -0.38 -9.68 -0.36 8.87e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg17724175 chr1:150552817 MCL1 0.25 8.36 0.31 3.79e-16 Tonsillectomy; BRCA cis rs7520050 0.933 rs6656022 chr1:46394315 A/G cg24296786 chr1:45957014 TESK2 0.44 9.82 0.36 2.77e-21 Red blood cell count;Reticulocyte count; BRCA cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg06766960 chr11:133703094 NA -0.61 -12.95 -0.46 3.03e-34 Childhood ear infection; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg21143896 chr7:2802374 GNA12 -0.36 -9.07 -0.34 1.44e-18 Height; BRCA cis rs6496044 0.568 rs12899946 chr15:86066082 C/T cg10818794 chr15:86012489 AKAP13 -0.29 -7.91 -0.3 1.1e-14 Interstitial lung disease; BRCA cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.79 -0.5 9.17e-43 Chronic sinus infection; BRCA cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.22 0.37 8.46e-23 Aortic root size; BRCA cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg17143192 chr8:8559678 CLDN23 0.56 10.88 0.4 2.06e-25 Obesity-related traits; BRCA cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg16339924 chr4:17578868 LAP3 0.67 17.04 0.56 6.2e-54 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10782582 0.609 rs1770889 chr1:76401166 A/G cg03433033 chr1:76189801 ACADM -0.4 -8.44 -0.32 2.16e-16 Daytime sleep phenotypes; BRCA trans rs1973993 0.561 rs6593609 chr1:96991652 C/T cg10631902 chr5:14652156 NA -0.41 -10.04 -0.37 4.12e-22 Weight; BRCA cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg00106254 chr7:1943704 MAD1L1 -0.3 -8.03 -0.3 4.78e-15 Bipolar disorder and schizophrenia; BRCA trans rs9409565 0.793 rs2486632 chr9:97196979 A/G cg05679027 chr9:99775184 HIATL2 -0.42 -9.29 -0.34 2.41e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11890956 chr21:40555474 PSMG1 1.04 29.7 0.76 1.93e-122 Cognitive function; BRCA cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg12311346 chr5:56204834 C5orf35 1.01 20.24 0.62 9.81e-71 Initial pursuit acceleration; BRCA cis rs243505 0.898 rs243527 chr7:148416104 G/T cg09806900 chr7:148480153 CUL1 -0.4 -8.34 -0.31 4.42e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg15242686 chr22:24348715 GSTTP1 -0.36 -8.83 -0.33 1e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs6582630 0.537 rs66855609 chr12:38299029 T/C cg06521331 chr12:34319734 NA -0.48 -9.25 -0.34 3.19e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs2836950 0.805 rs62223042 chr21:40683740 A/G cg17971929 chr21:40555470 PSMG1 -0.43 -8.78 -0.33 1.55e-17 Menarche (age at onset); BRCA cis rs9393777 0.623 rs7756567 chr6:26481642 T/G cg12826209 chr6:26865740 GUSBL1 0.56 9.17 0.34 6.68e-19 Intelligence (multi-trait analysis); BRCA cis rs1577917 0.917 rs1414201 chr6:86500316 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -7.89 -0.3 1.28e-14 Response to antipsychotic treatment; BRCA cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg00071950 chr4:10020882 SLC2A9 0.64 15.97 0.53 1.4e-48 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6700896 0.931 rs2211651 chr1:66156021 G/T cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.09e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs11190604 1.000 rs2298075 chr10:102247408 C/A cg07080220 chr10:102295463 HIF1AN 0.51 11.39 0.41 1.77e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9807989 0.507 rs13021177 chr2:103056493 A/G cg03938978 chr2:103052716 IL18RAP 0.28 8.13 0.31 2.17e-15 Asthma; BRCA cis rs364477 0.630 rs7031845 chr9:1005131 A/G cg13952963 chr9:998547 NA -0.41 -8.7 -0.33 2.87e-17 Major depressive disorder; BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg13880726 chr7:1868755 MAD1L1 0.52 10.4 0.38 1.71e-23 Bipolar disorder and schizophrenia; BRCA cis rs2635047 0.935 rs2576031 chr18:44658146 A/G cg19077165 chr18:44547161 KATNAL2 -0.44 -9.24 -0.34 3.53e-19 Educational attainment; BRCA cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.02 0.3 5.13e-15 Rheumatoid arthritis; BRCA cis rs12612619 0.579 rs11887277 chr2:27083269 A/G cg12368169 chr2:27073192 DPYSL5 -0.33 -10.19 -0.37 1.12e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7474896 0.515 rs2738208 chr10:38306128 A/G cg25427524 chr10:38739819 LOC399744 0.51 9.43 0.35 7.31e-20 Obesity (extreme); BRCA cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg24112000 chr20:60950667 NA -0.58 -12.61 -0.45 1.02e-32 Colorectal cancer; BRCA cis rs1443512 0.947 rs1822438 chr12:54342326 A/C cg17410650 chr12:54324560 NA -0.35 -8.29 -0.31 6.52e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs372883 0.580 rs2254038 chr21:30745722 C/T cg24692254 chr21:30365293 RNF160 0.42 9.62 0.36 1.45e-20 Pancreatic cancer; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg09177884 chr7:1199841 ZFAND2A -0.35 -7.83 -0.3 2.07e-14 Longevity;Endometriosis; BRCA cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg09165964 chr15:75287851 SCAMP5 -0.77 -18.03 -0.58 4.7e-59 Blood trace element (Zn levels); BRCA cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg06453172 chr10:134556979 INPP5A -0.6 -11.81 -0.42 3e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg11707556 chr5:10655725 ANKRD33B 0.43 9.52 0.35 3.53e-20 Height; BRCA cis rs3733585 0.605 rs4697710 chr4:10122649 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -9.91 -0.36 1.28e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1215050 0.791 rs165254 chr4:98763564 C/T cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2732480 0.577 rs2732457 chr12:48758379 A/G cg04545296 chr12:48745243 ZNF641 -0.24 -8.05 -0.3 4.02e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA trans rs61931739 0.500 rs1601628 chr12:34047375 A/C cg26384229 chr12:38710491 ALG10B 0.57 12.23 0.44 4.52e-31 Morning vs. evening chronotype; BRCA cis rs10501293 0.667 rs4565888 chr11:42986051 G/A cg03447554 chr11:43094025 NA 0.42 7.94 0.3 8.9e-15 Cognitive performance; BRCA cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg02175503 chr12:58329896 NA 0.52 11.2 0.4 1.07e-26 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg06064525 chr11:970664 AP2A2 0.48 16.03 0.54 7.75e-49 Alzheimer's disease (late onset); BRCA cis rs2742234 0.955 rs1800861 chr10:43613843 G/T cg15436174 chr10:43711423 RASGEF1A -0.43 -9.14 -0.34 7.94e-19 Hirschsprung disease; BRCA cis rs3849570 0.961 rs10154945 chr3:81833766 A/C cg07356753 chr3:81810745 GBE1 -0.47 -11.29 -0.41 4.35e-27 Waist circumference;Body mass index; BRCA cis rs514406 0.825 rs487453 chr1:53271225 T/C cg27535305 chr1:53392650 SCP2 0.33 8.28 0.31 7.16e-16 Monocyte count; BRCA cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 2.0500000000000001e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7582180 0.764 rs11682748 chr2:100925934 C/A cg14675211 chr2:100938903 LONRF2 0.49 11.18 0.4 1.27e-26 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg17971929 chr21:40555470 PSMG1 -0.61 -13.51 -0.47 9.1e-37 Cognitive function; BRCA cis rs7666738 0.830 rs921521 chr4:98838339 A/G cg17366294 chr4:99064904 C4orf37 0.42 9.9 0.36 1.33e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.915 rs7316734 chr12:123117425 A/G cg05707623 chr12:122985044 ZCCHC8 -0.45 -9.16 -0.34 7.06e-19 Body mass index; BRCA cis rs7772486 0.875 rs9399572 chr6:146362945 T/G cg23711669 chr6:146136114 FBXO30 0.69 16.02 0.54 7.97e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs17685 0.753 rs4732542 chr7:75663203 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -9.02 -0.34 2.16e-18 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg17830980 chr10:43048298 ZNF37B -0.58 -14.18 -0.49 7.01e-40 Extrinsic epigenetic age acceleration; BRCA cis rs68170813 0.523 rs10253172 chr7:106786474 C/T cg02696742 chr7:106810147 HBP1 0.62 9.87 0.36 1.82e-21 Coronary artery disease; BRCA cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg13298116 chr11:62369859 EML3;MTA2 0.38 9.35 0.35 1.4e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs611744 0.647 rs689275 chr8:109241822 T/C cg21045802 chr8:109455806 TTC35 0.35 8.01 0.3 5.3e-15 Dupuytren's disease; BRCA cis rs11055008 0.620 rs10845608 chr12:12836088 C/T cg04607235 chr12:12878440 APOLD1 0.43 8.83 0.33 1.03e-17 Pulse pressure; BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg05279229 chr7:1896384 MAD1L1 -0.45 -8.78 -0.33 1.55e-17 Bipolar disorder and schizophrenia; BRCA cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg00105475 chr2:10696890 NA 0.44 10.37 0.38 2.16e-23 Prostate cancer; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg22009923 chr11:832065 CD151 -0.46 -9.96 -0.37 8.37e-22 Mean platelet volume; BRCA cis rs9644630 1.000 rs4921657 chr8:19370867 C/G cg01280390 chr8:19363452 CSGALNACT1 0.42 9.4 0.35 9.23e-20 Oropharynx cancer; BRCA cis rs9309711 0.922 rs7561600 chr2:3486093 G/C cg16153549 chr2:3496821 NA -0.36 -8.24 -0.31 9.67e-16 Neurofibrillary tangles; BRCA trans rs3960554 0.529 rs7800970 chr7:75880198 C/T cg19862616 chr7:65841803 NCRNA00174 -0.44 -10.15 -0.37 1.59e-22 Eotaxin levels; BRCA cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.695 rs11057797 chr12:122860732 G/A cg05707623 chr12:122985044 ZCCHC8 0.49 9.42 0.35 7.86e-20 Body mass index; BRCA cis rs11711311 1.000 rs9288983 chr3:113488699 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.2 -0.37 1.01e-22 IgG glycosylation; BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.65 11.94 0.43 8.2e-30 Gut microbiome composition (summer); BRCA cis rs1003719 0.788 rs59637309 chr21:38475398 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs61931739 0.517 rs4104182 chr12:34081343 G/A cg06521331 chr12:34319734 NA -0.62 -11.23 -0.41 8.09e-27 Morning vs. evening chronotype; BRCA cis rs2204008 0.774 rs11616004 chr12:38278822 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs733175 0.857 rs7666545 chr4:10012372 C/T cg00071950 chr4:10020882 SLC2A9 0.43 8.39 0.32 3e-16 Psychosis and Alzheimer's disease; BRCA cis rs478304 0.934 rs498354 chr11:65528213 A/G cg08755490 chr11:65554678 OVOL1 0.55 11.5 0.41 5.88e-28 Acne (severe); BRCA cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7264396 0.635 rs6058358 chr20:34492560 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.74 -0.5 1.48e-42 Total cholesterol levels; BRCA cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg15556689 chr8:8085844 FLJ10661 0.5 13.8 0.48 4.24e-38 Systolic blood pressure; BRCA cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg23711669 chr6:146136114 FBXO30 0.79 18.81 0.6 3.73e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg20891283 chr12:69753455 YEATS4 0.73 21.79 0.65 3.72e-79 Blood protein levels; BRCA cis rs2559856 1.000 rs2695282 chr12:102089502 A/G cg12924262 chr12:102091054 CHPT1 -0.38 -8.65 -0.32 4.2e-17 Blood protein levels; BRCA cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg00677455 chr12:58241039 CTDSP2 0.8 17.9 0.58 2.32e-58 Multiple sclerosis; BRCA cis rs992157 1.000 rs992157 chr2:219154781 A/G cg00012203 chr2:219082015 ARPC2 -0.61 -12.92 -0.46 4.24e-34 Colorectal cancer; BRCA cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg10802521 chr3:52805072 NEK4 -0.31 -8.09 -0.3 3.02e-15 Bipolar disorder; BRCA cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg03213289 chr20:61660250 NA 0.61 16.2 0.54 1e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg26408565 chr15:76604113 ETFA -0.49 -10.39 -0.38 1.79e-23 Blood metabolite levels; BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs2806561 0.754 rs750354 chr1:23297406 T/C cg19743168 chr1:23544995 NA -0.4 -9.59 -0.35 1.88e-20 Height; BRCA cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg17971929 chr21:40555470 PSMG1 0.52 11.69 0.42 9.84e-29 Cognitive function; BRCA cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg02297831 chr4:17616191 MED28 -0.34 -7.92 -0.3 1.03e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg07148914 chr20:33460835 GGT7 -0.37 -7.97 -0.3 7.47e-15 Glomerular filtration rate (creatinine); BRCA cis rs27434 0.529 rs42443 chr5:96156224 G/A cg16492584 chr5:96139282 ERAP1 -0.51 -12.74 -0.45 2.66e-33 Ankylosing spondylitis; BRCA cis rs730566 1.000 rs730566 chr3:48487048 G/T cg07636037 chr3:49044803 WDR6 -0.52 -9.84 -0.36 2.19e-21 Prion diseases; BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg26314531 chr2:26401878 FAM59B -0.97 -16.88 -0.56 3.74e-53 Gut microbiome composition (summer); BRCA cis rs17125944 0.505 rs77137752 chr14:53230496 G/T cg13660082 chr14:53194042 PSMC6 -0.58 -8.74 -0.33 2.05e-17 Alzheimer's disease (late onset); BRCA cis rs11764590 0.585 rs11772463 chr7:2078132 A/C cg02743256 chr7:2109353 MAD1L1 -0.46 -8.13 -0.31 2.27e-15 Neuroticism; BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg04267008 chr7:1944627 MAD1L1 0.44 10.02 0.37 4.62e-22 Bipolar disorder and schizophrenia; BRCA cis rs3820928 0.605 rs13410141 chr2:227805529 A/G cg11843606 chr2:227700838 RHBDD1 -0.5 -11.61 -0.42 2.1e-28 Pulmonary function; BRCA trans rs12310956 0.510 rs7302434 chr12:33886819 G/A cg26384229 chr12:38710491 ALG10B 0.39 9.26 0.34 3.1400000000000002e-19 Morning vs. evening chronotype; BRCA cis rs3106136 0.527 rs2632411 chr4:95149434 G/A cg11021082 chr4:95130006 SMARCAD1 -0.44 -9.99 -0.37 6.09e-22 Capecitabine sensitivity; BRCA cis rs72781680 0.716 rs7564732 chr2:24034178 C/T cg08917208 chr2:24149416 ATAD2B 0.61 10.54 0.38 4.7e-24 Lymphocyte counts; BRCA cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg01579765 chr21:45077557 HSF2BP -0.4 -11.05 -0.4 4.27e-26 Mean corpuscular volume; BRCA cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.48 -0.32 1.6e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg13256891 chr4:100009986 ADH5 0.5 10.33 0.38 3.05e-23 Alcohol dependence; BRCA cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg00105475 chr2:10696890 NA 0.44 10.29 0.38 4.39e-23 Prostate cancer; BRCA cis rs7766436 0.687 rs10485012 chr6:22607026 A/C cg13666174 chr6:22585274 NA -0.36 -8.48 -0.32 1.54e-16 Coronary artery disease; BRCA cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg06115741 chr20:33292138 TP53INP2 0.49 10.84 0.39 3.12e-25 Coronary artery disease; BRCA cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.59 0.57 8.45e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.806 rs11525001 chr12:38234397 A/G cg13010199 chr12:38710504 ALG10B 0.42 8.55 0.32 9.39e-17 Bladder cancer; BRCA cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg01262667 chr19:19385393 TM6SF2 -0.38 -9.74 -0.36 5.42e-21 Tonsillectomy; BRCA trans rs2727020 0.894 rs3862342 chr11:49357043 C/T cg15704280 chr7:45808275 SEPT13 -0.73 -14.87 -0.51 3.56e-43 Coronary artery disease; BRCA cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.59 7.99 0.3 6.45e-15 Diabetic retinopathy; BRCA cis rs9355610 0.609 rs62436424 chr6:167374258 A/G cg23791538 chr6:167370224 RNASET2 0.43 8.47 0.32 1.64e-16 Graves' disease; BRCA cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg04586622 chr2:25135609 ADCY3 0.46 11.5 0.41 5.76e-28 Body mass index; BRCA cis rs8030485 0.730 rs57488047 chr15:79403002 T/C cg17916960 chr15:79447300 NA 0.37 8.55 0.32 9.22e-17 Left ventricle wall thickness; BRCA cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg06640241 chr16:89574553 SPG7 0.88 23.14 0.68 1.7e-86 Multiple myeloma (IgH translocation); BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg04944784 chr2:26401820 FAM59B 1.0 16.64 0.55 6.7e-52 Gut microbiome composition (summer); BRCA cis rs10927875 0.541 rs1739841 chr1:16342727 A/G cg06159980 chr1:16340746 HSPB7 -0.39 -8.85 -0.33 8.44e-18 Dilated cardiomyopathy; BRCA cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs736408 0.924 rs2535629 chr3:52833219 C/T cg11645453 chr3:52864694 ITIH4 0.32 7.86 0.3 1.63e-14 Bipolar disorder; BRCA cis rs10791097 0.694 rs3190331 chr11:130748131 C/T cg12179176 chr11:130786555 SNX19 -0.72 -18.31 -0.59 1.63e-60 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg24060327 chr5:131705240 SLC22A5 -0.43 -8.85 -0.33 8.32e-18 Acylcarnitine levels; BRCA cis rs6973256 0.834 rs11768150 chr7:133335011 T/G cg07491979 chr7:133331646 EXOC4 -0.39 -8.91 -0.33 5.11e-18 Intelligence (multi-trait analysis); BRCA cis rs7617773 0.963 rs12495221 chr3:48179178 C/T cg11946769 chr3:48343235 NME6 -0.39 -8.86 -0.33 7.66e-18 Coronary artery disease; BRCA cis rs1003719 0.715 rs2156078 chr21:38546473 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg21475434 chr5:93447410 FAM172A 0.71 8.79 0.33 1.36e-17 Diabetic retinopathy; BRCA cis rs4819052 0.851 rs58644915 chr21:46669912 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 13.83 0.48 3.19e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7904985 0.889 rs1078789 chr10:88110247 C/T cg07322936 chr10:88137208 NA -0.45 -9.6 -0.36 1.72e-20 Barrett's esophagus; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.39e-15 Total body bone mineral density; BRCA cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.71 -0.36 6.91e-21 Tonsillectomy; BRCA cis rs8114671 0.527 rs6060112 chr20:33489276 A/T cg07148914 chr20:33460835 GGT7 0.48 10.33 0.38 3e-23 Height; BRCA cis rs8114671 0.585 rs2236271 chr20:33523840 G/T cg24642439 chr20:33292090 TP53INP2 -0.4 -7.86 -0.3 1.66e-14 Height; BRCA cis rs6545883 0.894 rs12622458 chr2:61523554 A/C cg15711740 chr2:61764176 XPO1 0.49 11.92 0.43 9.98e-30 Tuberculosis; BRCA cis rs9788682 0.748 rs569207 chr15:78873119 A/G cg24631222 chr15:78858424 CHRNA5 -0.49 -10.52 -0.38 5.36e-24 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7246657 0.663 rs9304568 chr19:38054508 C/A cg18154014 chr19:37997991 ZNF793 0.47 8.94 0.33 4.16e-18 Coronary artery calcification; BRCA trans rs11098499 0.909 rs11723757 chr4:120299669 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.59 0.42 2.61e-28 Corneal astigmatism; BRCA cis rs250677 0.687 rs168750 chr5:148446756 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -8.69 -0.33 3.04e-17 Breast cancer; BRCA cis rs7572733 0.534 rs1401092 chr2:198792320 C/A cg00792783 chr2:198669748 PLCL1 -0.46 -9.98 -0.37 7.05e-22 Dermatomyositis; BRCA cis rs13102973 0.899 rs13127659 chr4:135900604 G/A cg14419869 chr4:135874104 NA 0.46 9.37 0.35 1.18e-19 Subjective well-being; BRCA cis rs11887277 0.528 rs13016101 chr2:27045097 C/T cg12368169 chr2:27073192 DPYSL5 -0.28 -8.07 -0.3 3.5e-15 Obesity-related traits; BRCA cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg14440974 chr22:39074834 NA 0.38 8.94 0.33 4.15e-18 Menopause (age at onset); BRCA trans rs7647973 0.710 rs1491983 chr3:49639803 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.95 -0.3 8.62e-15 Menarche (age at onset); BRCA cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg24060327 chr5:131705240 SLC22A5 0.61 11.36 0.41 2.18e-27 Breast cancer; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg27170947 chr2:26402098 FAM59B -0.65 -11.25 -0.41 6.26e-27 Gut microbiome composition (summer); BRCA trans rs1005277 0.540 rs1987431 chr10:37988887 T/C cg17830980 chr10:43048298 ZNF37B -0.42 -9.91 -0.36 1.2e-21 Extrinsic epigenetic age acceleration; BRCA cis rs9733 0.818 rs6694531 chr1:150683512 C/A cg13175981 chr1:150552382 MCL1 0.47 10.51 0.38 5.93e-24 Tonsillectomy; BRCA cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.69e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg12564285 chr5:131593104 PDLIM4 0.34 7.87 0.3 1.52e-14 Breast cancer; BRCA cis rs7552404 1.000 rs4646961 chr1:76217169 G/A cg03433033 chr1:76189801 ACADM 0.76 17.39 0.57 9.52e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg09184832 chr6:79620586 NA -0.52 -11.41 -0.41 1.46e-27 Intelligence (multi-trait analysis); BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg23131131 chr22:24373011 LOC391322 -0.39 -8.78 -0.33 1.46e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9287719 0.625 rs12473787 chr2:10717194 G/C cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.23e-19 Prostate cancer; BRCA cis rs6964587 1.000 rs7800582 chr7:91701346 G/A cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA trans rs208515 0.525 rs10944859 chr6:66665197 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 15.87 0.53 4.53e-48 Exhaled nitric oxide levels; BRCA cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg14844989 chr11:31128820 NA -0.45 -9.62 -0.36 1.51e-20 Red blood cell count; BRCA cis rs637571 0.584 rs594689 chr11:65635559 G/A cg04055107 chr11:65626734 MUS81;CFL1 -0.47 -9.84 -0.36 2.27e-21 Eosinophil percentage of white cells; BRCA cis rs9815354 0.638 rs76276404 chr3:41931770 A/G cg03022575 chr3:42003672 ULK4 0.69 9.5 0.35 4.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg18225595 chr11:63971243 STIP1 0.56 13.62 0.47 2.81e-37 Platelet count; BRCA cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg04455712 chr21:45112962 RRP1B 0.38 10.21 0.37 8.61e-23 Mean corpuscular volume; BRCA trans rs637571 0.522 rs538954 chr11:65756808 A/G cg17712092 chr4:129076599 LARP1B 0.56 13.55 0.47 5.98e-37 Eosinophil percentage of white cells; BRCA cis rs8078723 0.668 rs3859192 chr17:38128648 C/T cg17344932 chr17:38183730 MED24;SNORD124 -0.33 -7.89 -0.3 1.35e-14 C-reactive protein and white blood cell count;Neutrophil count;White blood cell count;White blood cell count (neutrophil); BRCA cis rs9815354 0.812 rs73081370 chr3:41916258 G/C cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg08048268 chr3:133502702 NA 0.42 10.55 0.39 4.16e-24 Iron status biomarkers; BRCA trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg23533926 chr12:111358616 MYL2 -0.42 -8.73 -0.33 2.26e-17 Extrinsic epigenetic age acceleration; BRCA cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg03264133 chr6:25882463 NA -0.55 -11.58 -0.42 2.84e-28 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg04450456 chr4:17643702 FAM184B 0.39 11.4 0.41 1.57e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6598955 0.671 rs12089149 chr1:26638500 C/A cg00852783 chr1:26633632 UBXN11 -0.46 -7.98 -0.3 6.7e-15 Obesity-related traits; BRCA cis rs35306767 0.903 rs12240651 chr10:943656 A/G cg26597838 chr10:835615 NA 1.03 18.41 0.59 5.06e-61 Eosinophil percentage of granulocytes; BRCA trans rs3857536 0.706 rs2157963 chr6:66945449 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs11622475 1.000 rs2269186 chr14:104379912 C/T cg12183467 chr14:104352244 NA -0.5 -10.44 -0.38 1.16e-23 Bipolar disorder; BRCA trans rs11098499 0.754 rs878376 chr4:120237702 G/A cg25214090 chr10:38739885 LOC399744 0.46 10.45 0.38 1.05e-23 Corneal astigmatism; BRCA cis rs72772090 0.539 rs11748519 chr5:96119328 C/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2777491 0.915 rs7180418 chr15:41629502 A/C cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.94 -0.48 9.05e-39 Ulcerative colitis; BRCA cis rs634534 0.561 rs14157 chr11:65769780 T/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.61 13.64 0.47 2.35e-37 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.22 -0.34 4.36e-19 Total body bone mineral density; BRCA cis rs4285028 0.747 rs77790376 chr3:121492211 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -16.27 -0.54 4.89e-50 Multiple sclerosis; BRCA cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg23711669 chr6:146136114 FBXO30 0.72 14.5 0.5 2.19e-41 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.863 rs36040693 chr4:120477616 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.27e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2204008 0.837 rs11169157 chr12:37980047 T/C cg06521331 chr12:34319734 NA -0.54 -10.27 -0.38 5.26e-23 Bladder cancer; BRCA cis rs2336384 1.000 rs2103876 chr1:12053100 C/T cg13216073 chr1:12042593 MFN2 0.45 9.63 0.36 1.34e-20 Platelet count; BRCA cis rs2658782 0.789 rs3019206 chr11:93111073 A/G cg15737290 chr11:93063684 CCDC67 0.48 10.03 0.37 4.27e-22 Pulmonary function decline; BRCA cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.24e-23 Motion sickness; BRCA cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.79 11.06 0.4 3.84e-26 Initial pursuit acceleration; BRCA cis rs921968 0.541 rs496674 chr2:219432569 G/A cg02176678 chr2:219576539 TTLL4 0.46 12.21 0.43 5.86e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg22875332 chr1:76189707 ACADM 0.65 15.59 0.52 1.12e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg07549590 chr16:15018862 NA -0.51 -12.7 -0.45 4.19e-33 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs4363385 0.747 rs2339495 chr1:152975116 A/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs3806843 0.838 rs2563289 chr5:140122766 T/A cg16179182 chr5:140090404 VTRNA1-1 0.42 9.68 0.36 9.34e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs2739330 0.761 rs5760176 chr22:24402321 A/G cg06437703 chr8:37914619 EIF4EBP1 0.4 10.62 0.39 2.33e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.14 0.54 2.08e-49 Smoking behavior; BRCA cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg20476274 chr7:133979776 SLC35B4 0.7 21.15 0.64 1.2e-75 Mean platelet volume; BRCA cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.18 0.31 1.51e-15 Axial length; BRCA cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg05283184 chr6:79620031 NA -0.43 -11.08 -0.4 3.24e-26 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg11833968 chr6:79620685 NA -0.41 -9.27 -0.34 2.8e-19 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.954 rs12499324 chr4:120393786 C/T cg09307838 chr4:120376055 NA 0.72 15.41 0.52 8.47e-46 Corneal astigmatism; BRCA cis rs1468333 1.000 rs6867242 chr5:137561186 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.27 0.34 2.74e-19 Resting heart rate; BRCA cis rs17023223 0.581 rs11811859 chr1:119707680 A/G cg05756136 chr1:119680316 WARS2 -0.41 -7.94 -0.3 9.35e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg12373951 chr3:133503437 NA 0.45 10.64 0.39 1.89e-24 Iron status biomarkers; BRCA cis rs6446731 0.636 rs2157092 chr4:3273092 G/C cg08886695 chr4:3369023 RGS12 -0.37 -9.7 -0.36 7.62e-21 Mean platelet volume; BRCA cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg21770322 chr7:97807741 LMTK2 0.41 11.05 0.4 4.26e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs61931739 0.500 rs11053212 chr12:34466116 T/G cg06521331 chr12:34319734 NA -0.56 -9.91 -0.37 1.24e-21 Morning vs. evening chronotype; BRCA trans rs2270927 0.510 rs35930860 chr5:75579946 T/C cg13563193 chr19:33072644 PDCD5 0.9 10.35 0.38 2.48e-23 Mean corpuscular volume; BRCA cis rs7666738 0.800 rs2865987 chr4:99067852 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.65 0.39 1.71e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9653442 0.675 rs2871326 chr2:100662010 T/C cg22139774 chr2:100720529 AFF3 -0.29 -8.16 -0.31 1.72e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs4925386 0.681 rs2427295 chr20:60927431 G/A cg06026331 chr20:60912101 LAMA5 0.63 12.5 0.44 3.03e-32 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs1499972 0.941 rs6794831 chr3:117642484 C/A cg07612923 chr3:117604196 NA 0.6 8.13 0.31 2.26e-15 Schizophrenia; BRCA cis rs372883 0.648 rs4817279 chr21:30638285 T/C cg08807101 chr21:30365312 RNF160 -0.42 -8.82 -0.33 1.13e-17 Pancreatic cancer; BRCA cis rs2180341 0.960 rs7751865 chr6:127683040 G/A cg27446573 chr6:127587934 RNF146 0.81 18.44 0.59 3.29e-61 Breast cancer; BRCA cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg07917127 chr4:99064746 C4orf37 0.46 8.41 0.32 2.61e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs9649465 0.967 rs10224062 chr7:123304609 G/A cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.66e-16 Migraine; BRCA cis rs2832191 0.716 rs7509628 chr21:30454252 C/T cg08807101 chr21:30365312 RNF160 0.74 19.4 0.61 2.77e-66 Dental caries; BRCA cis rs965469 1.000 rs2236098 chr20:3267133 A/G cg25506879 chr20:3388711 C20orf194 -0.51 -10.23 -0.38 7.7e-23 IFN-related cytopenia; BRCA trans rs7200543 1.000 rs16966952 chr16:15135943 C/T cg24683922 chr1:11983373 KIAA2013 -0.37 -8.42 -0.32 2.42e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs1005277 0.579 rs2472182 chr10:38388865 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA cis rs4332037 0.539 rs55993248 chr7:2071132 A/G cg23422044 chr7:1970798 MAD1L1 -0.59 -10.93 -0.4 1.36e-25 Bipolar disorder; BRCA cis rs7524258 0.868 rs4243825 chr1:7308264 T/C cg07173049 chr1:7289937 CAMTA1 0.53 12.71 0.45 3.73e-33 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs7246657 0.722 rs4802051 chr19:38072328 C/A cg14683738 chr19:37701593 ZNF585B 0.46 7.81 0.3 2.31e-14 Coronary artery calcification; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.75 -0.45 2.45e-33 Lymphocyte counts; BRCA cis rs7666738 0.830 rs17026973 chr4:98680041 T/A cg05340658 chr4:99064831 C4orf37 0.63 14.68 0.5 2.98e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg12935359 chr14:103987150 CKB 0.64 14.95 0.51 1.57e-43 Intelligence (multi-trait analysis); BRCA cis rs2637266 0.935 rs2583053 chr10:78402416 A/G cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg03354898 chr7:1950403 MAD1L1 -0.47 -9.92 -0.37 1.1e-21 Bipolar disorder and schizophrenia; BRCA cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -9.04 -0.34 1.83e-18 Schizophrenia; BRCA cis rs7766436 0.885 rs12111204 chr6:22578227 C/T cg13666174 chr6:22585274 NA -0.49 -11.27 -0.41 5.36e-27 Coronary artery disease; BRCA cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg24920358 chr1:40204285 PPIE 0.34 7.94 0.3 9.15e-15 Blood protein levels; BRCA cis rs250677 1.000 rs28173 chr5:148423573 C/T cg18129178 chr5:148520854 ABLIM3 -0.57 -11.84 -0.42 2.29e-29 Breast cancer; BRCA cis rs2153535 0.580 rs6941670 chr6:8446346 G/A cg21535247 chr6:8435926 SLC35B3 0.4 8.99 0.33 2.88e-18 Motion sickness; BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg10433463 chr1:1889099 KIAA1751 0.35 9.33 0.35 1.77e-19 Body mass index; BRCA cis rs1829883 0.804 rs114992703 chr5:98813521 A/G cg08333243 chr5:99726346 NA -0.35 -8.0 -0.3 5.99e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs10754283 0.557 rs1215508 chr1:90088697 C/T cg21401794 chr1:90099060 LRRC8C 0.37 8.41 0.32 2.68e-16 Amyotrophic lateral sclerosis (sporadic); BRCA trans rs11976180 1.000 rs2961119 chr7:143755852 T/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.44 -8.2 -0.31 1.32e-15 Obesity-related traits; BRCA cis rs2070488 0.662 rs7652475 chr3:38481341 C/T cg24069376 chr3:38537580 EXOG 0.3 7.84 0.3 1.92e-14 Electrocardiographic conduction measures; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg16145915 chr7:1198662 ZFAND2A -0.72 -20.66 -0.63 5.41e-73 Longevity;Endometriosis; BRCA cis rs17095355 0.901 rs28365866 chr10:111767214 C/T cg00817464 chr10:111662876 XPNPEP1 -0.45 -9.86 -0.36 1.97e-21 Biliary atresia; BRCA cis rs1153858 1.000 rs72623915 chr15:45647433 C/T cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg15395560 chr15:45543142 SLC28A2 -0.3 -7.85 -0.3 1.79e-14 Uric acid levels; BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.88 0.36 1.58e-21 Tonsillectomy; BRCA cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.59 0.55 1.2e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs911119 1.000 rs71334202 chr20:23618652 A/C cg16589663 chr20:23618590 CST3 0.46 8.93 0.33 4.59e-18 Chronic kidney disease; BRCA cis rs17376456 0.877 rs10063045 chr5:93457584 A/T cg21475434 chr5:93447410 FAM172A 0.74 8.8 0.33 1.32e-17 Diabetic retinopathy; BRCA cis rs9287719 0.967 rs6759714 chr2:10747207 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.74e-15 Prostate cancer; BRCA cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg21535247 chr6:8435926 SLC35B3 -0.4 -8.93 -0.33 4.49e-18 Motion sickness; BRCA cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2147904 0.867 rs1408947 chr1:42364198 C/T cg16685388 chr1:42384056 HIVEP3 0.31 8.79 0.33 1.39e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs12474201 0.862 rs7562173 chr2:46976217 C/G cg06386533 chr2:46925753 SOCS5 -0.83 -18.52 -0.59 1.3e-61 Height; BRCA cis rs67460515 1.000 rs67460515 chr3:161068566 T/C cg03342759 chr3:160939853 NMD3 -0.72 -16.51 -0.55 3.04e-51 Parkinson's disease; BRCA cis rs2019216 0.521 rs6565386 chr17:21901755 A/G cg22648282 chr17:21454238 C17orf51 0.41 9.33 0.35 1.68e-19 Pelvic organ prolapse; BRCA cis rs2425143 1.000 rs6058325 chr20:34388806 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.07 -0.34 1.48e-18 Blood protein levels; BRCA cis rs1005277 0.579 rs2505198 chr10:38393183 A/C cg25427524 chr10:38739819 LOC399744 -0.7 -17.22 -0.56 6.71e-55 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.17 -0.43 8.62e-31 Alzheimer's disease; BRCA cis rs2455799 0.533 rs924754 chr3:15756215 A/T cg16303742 chr3:15540471 COLQ -0.35 -8.37 -0.31 3.76e-16 Mean platelet volume; BRCA cis rs11051970 0.611 rs10844197 chr12:32561015 A/C cg02745156 chr12:32552066 NA 0.25 8.38 0.31 3.44e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg26384229 chr12:38710491 ALG10B 0.74 17.51 0.57 2.37e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs2130392 1.000 rs2130392 chr4:185639169 A/G cg04058563 chr4:185651563 MLF1IP 0.33 7.82 0.3 2.18e-14 Kawasaki disease; BRCA cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg11764359 chr7:65958608 NA -0.75 -16.9 -0.56 2.91e-53 Aortic root size; BRCA cis rs61931739 0.517 rs11053067 chr12:34191391 T/C cg06521331 chr12:34319734 NA -0.63 -11.57 -0.42 2.98e-28 Morning vs. evening chronotype; BRCA cis rs10751667 0.643 rs10794350 chr11:946070 A/G cg10932868 chr11:921992 NA 0.51 13.18 0.46 2.97e-35 Alzheimer's disease (late onset); BRCA cis rs72772090 0.539 rs17405676 chr5:96182615 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -11.67 -0.42 1.19e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6460942 0.915 rs62448598 chr7:12453762 T/C cg20607287 chr7:12443886 VWDE -0.58 -8.36 -0.31 4.04e-16 Coronary artery disease; BRCA cis rs6964587 0.541 rs6947170 chr7:91451471 A/G cg17063962 chr7:91808500 NA 0.54 12.3 0.44 2.35e-31 Breast cancer; BRCA cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 15.63 0.53 7.54e-47 Smoking behavior; BRCA cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg20818283 chr2:191399100 TMEM194B 0.42 9.66 0.36 1.03e-20 Pulse pressure; BRCA cis rs67311347 1.000 rs11715214 chr3:40403004 C/A cg09455208 chr3:40491958 NA 0.41 9.75 0.36 5.14e-21 Renal cell carcinoma; BRCA trans rs629535 0.814 rs549643 chr8:70062884 C/T cg21567404 chr3:27674614 NA 0.89 18.27 0.59 2.64e-60 Dupuytren's disease; BRCA cis rs870825 0.616 rs6817521 chr4:185649827 A/G cg04058563 chr4:185651563 MLF1IP -0.77 -17.42 -0.57 6.61e-56 Blood protein levels; BRCA cis rs9814567 1.000 rs4572812 chr3:134291177 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.78 0.62 2.8e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4595586 0.545 rs9668716 chr12:39378833 G/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg16506815 chr2:162101123 NA 0.51 11.12 0.4 2.15e-26 Intelligence (multi-trait analysis); BRCA cis rs9815354 0.812 rs73073226 chr3:42005838 T/C cg03022575 chr3:42003672 ULK4 0.65 9.49 0.35 4.62e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg14349672 chr11:133703707 NA -0.43 -9.58 -0.35 2.11e-20 Childhood ear infection; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26314531 chr2:26401878 FAM59B -0.91 -15.95 -0.53 1.79e-48 Gut microbiome composition (summer); BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg16606324 chr3:10149918 C3orf24 0.56 11.2 0.4 1.08e-26 Alzheimer's disease; BRCA cis rs1059312 0.500 rs12303338 chr12:129276641 C/T cg09035930 chr12:129282057 SLC15A4 -0.44 -11.81 -0.42 2.92e-29 Systemic lupus erythematosus; BRCA cis rs7103648 0.966 rs10769263 chr11:47417183 A/C cg03711944 chr11:47377212 SPI1 -0.43 -11.71 -0.42 8.08e-29 Diastolic blood pressure;Systolic blood pressure; BRCA trans rs61931739 0.500 rs6488222 chr12:34526289 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg20887711 chr4:1340912 KIAA1530 0.4 9.72 0.36 6.64e-21 Longevity; BRCA cis rs2795502 0.882 rs2744087 chr10:43340270 A/C cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs2282802 0.685 rs13359519 chr5:139654664 G/A cg26211634 chr5:139558579 C5orf32 0.35 8.35 0.31 4.13e-16 Intelligence (multi-trait analysis); BRCA cis rs6426558 0.502 rs1929858 chr1:227220175 C/A cg10327440 chr1:227177885 CDC42BPA 0.48 9.33 0.35 1.77e-19 Neutrophil percentage of white cells; BRCA cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg05535760 chr7:792225 HEATR2 0.73 13.22 0.46 1.96e-35 Cerebrospinal P-tau181p levels; BRCA cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7020830 0.505 rs12553878 chr9:37095705 C/T cg14294708 chr9:37120828 ZCCHC7 0.79 18.74 0.6 9.27e-63 Schizophrenia; BRCA cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg02931644 chr1:25747376 RHCE 0.4 11.18 0.4 1.28e-26 Erythrocyte sedimentation rate; BRCA cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg21856205 chr7:94953877 PON1 -0.37 -8.03 -0.3 4.78e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs853679 0.517 rs67878650 chr6:28142587 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.99 0.3 6.41e-15 Depression; BRCA cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg17892150 chr10:133769511 PPP2R2D -0.72 -15.45 -0.52 5.26e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.62 -14.31 -0.49 1.79e-40 Personality dimensions; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.63 -13.51 -0.47 9.58e-37 Lymphocyte counts; BRCA cis rs9337951 0.556 rs2487927 chr10:30311366 C/T cg00730780 chr10:30316187 KIAA1462 -0.49 -10.29 -0.38 4.24e-23 Pulse pressure;Coronary artery disease; BRCA cis rs11051970 0.594 rs325418 chr12:32572517 T/C cg24626660 chr12:32551988 NA 0.28 8.23 0.31 1.01e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs12760731 0.720 rs2862379 chr1:178442906 T/A cg00404053 chr1:178313656 RASAL2 0.61 8.08 0.3 3.13e-15 Obesity-related traits; BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg01262667 chr19:19385393 TM6SF2 0.4 10.27 0.38 5.28e-23 Tonsillectomy; BRCA trans rs3942852 0.806 rs11039515 chr11:48119474 A/G cg15704280 chr7:45808275 SEPT13 0.47 8.94 0.33 4.25e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg04267008 chr7:1944627 MAD1L1 -0.65 -13.77 -0.48 5.9e-38 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs2288073 1.000 rs6708328 chr2:24412413 A/G cg26838691 chr2:24397539 C2orf84 -0.48 -8.85 -0.33 8.21e-18 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7617773 0.817 rs9847953 chr3:48282695 A/G cg11946769 chr3:48343235 NME6 0.62 13.82 0.48 3.28e-38 Coronary artery disease; BRCA cis rs838147 0.507 rs692854 chr19:49209464 C/A cg07051648 chr19:49177693 NTN5;SEC1 -0.42 -8.02 -0.3 5.22e-15 Dietary macronutrient intake; BRCA cis rs3784262 0.669 rs12915508 chr15:58302036 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.09 -0.37 2.64e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg18876405 chr7:65276391 NA 0.5 11.08 0.4 3.09e-26 Aortic root size; BRCA cis rs1874326 0.524 rs6467772 chr7:138113643 A/G cg18008034 chr7:138118925 NA -0.44 -9.21 -0.34 4.58e-19 Quantitative traits; BRCA cis rs9467711 0.591 rs116201501 chr6:25999149 C/T cg08501292 chr6:25962987 TRIM38 0.59 8.02 0.3 4.97e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.07 0.3 3.56e-15 Aortic root size; BRCA cis rs858239 0.601 rs4599714 chr7:23168801 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.95 0.43 7.21e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs11690935 0.959 rs67204065 chr2:172672624 G/A cg13550731 chr2:172543902 DYNC1I2 -0.87 -26.72 -0.73 3.72e-106 Schizophrenia; BRCA cis rs6460942 1.000 rs112996286 chr7:12315741 G/C cg06484146 chr7:12443880 VWDE -0.63 -8.69 -0.33 2.98e-17 Coronary artery disease; BRCA cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg11890956 chr21:40555474 PSMG1 -0.64 -14.33 -0.49 1.34e-40 Menarche (age at onset); BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg24642844 chr7:1081250 C7orf50 -0.91 -16.39 -0.54 1.21e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg24829409 chr8:58192753 C8orf71 -0.59 -12.19 -0.43 7.04e-31 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.951 rs11253530 chr10:993729 T/C cg26597838 chr10:835615 NA 1.03 17.16 0.56 1.49e-54 Eosinophil percentage of granulocytes; BRCA cis rs9790314 1.000 rs336569 chr3:161072346 T/G cg04691961 chr3:161091175 C3orf57 -0.6 -15.18 -0.51 1.1e-44 Morning vs. evening chronotype; BRCA cis rs12612619 0.695 rs4665935 chr2:27229892 C/A cg00617064 chr2:27272375 NA 0.31 8.27 0.31 7.54e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.18 0.31 1.53e-15 Cardiac Troponin-T levels; BRCA cis rs1865760 0.892 rs9379806 chr6:25940958 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.83 0.36 2.56e-21 Height; BRCA trans rs911555 0.692 rs60235428 chr14:103904350 T/C cg17675199 chr6:35436792 RPL10A -0.31 -8.21 -0.31 1.19e-15 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.726 rs4682844 chr3:46982737 T/C cg27129171 chr3:47204927 SETD2 -0.71 -16.79 -0.55 1.08e-52 Colorectal cancer; BRCA cis rs2016266 0.855 rs930900 chr12:53727545 T/C cg26875137 chr12:53738046 NA 0.38 9.48 0.35 4.78e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs847577 0.748 rs940430 chr7:97716540 A/G cg21770322 chr7:97807741 LMTK2 0.58 16.99 0.56 1.12e-53 Breast cancer; BRCA cis rs7666738 0.544 rs35160902 chr4:98974690 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.73 0.55 2.19e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 0.636 rs6456694 chr6:25712894 C/T cg17691542 chr6:26056736 HIST1H1C 0.48 9.15 0.34 7.35e-19 Iron status biomarkers; BRCA trans rs6952808 0.595 rs3778984 chr7:2166514 T/C cg04565464 chr8:145669602 NFKBIL2 0.42 9.47 0.35 5.25e-20 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg23711669 chr6:146136114 FBXO30 -0.78 -18.09 -0.58 2.33e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs546131 0.928 rs553789 chr11:34827579 G/A cg06937548 chr11:34938143 PDHX;APIP 0.45 8.58 0.32 7.4e-17 Lung disease severity in cystic fibrosis; BRCA cis rs35146811 0.660 rs3779045 chr7:99779259 T/C cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg21535247 chr6:8435926 SLC35B3 -0.39 -8.76 -0.33 1.7e-17 Motion sickness; BRCA cis rs35110281 0.667 rs4818859 chr21:45117120 G/A cg04455712 chr21:45112962 RRP1B 0.44 11.6 0.42 2.2e-28 Mean corpuscular volume; BRCA cis rs7172677 0.501 rs8041446 chr15:75394517 C/T cg14664628 chr15:75095509 CSK 0.39 9.11 0.34 1.08e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg23625390 chr15:77176239 SCAPER 0.39 9.07 0.34 1.49e-18 Blood metabolite levels; BRCA cis rs7666738 0.791 rs1405766 chr4:98965389 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs58688157 0.705 rs12419694 chr11:598033 C/T cg16486109 chr11:613632 IRF7 0.42 9.0 0.34 2.57e-18 Systemic lupus erythematosus; BRCA cis rs1801251 0.778 rs2250654 chr2:233752376 A/T cg08000102 chr2:233561755 GIGYF2 -0.46 -10.03 -0.37 4.4e-22 Coronary artery disease; BRCA trans rs11098499 0.532 rs12512646 chr4:120585733 G/A cg25214090 chr10:38739885 LOC399744 0.46 10.1 0.37 2.32e-22 Corneal astigmatism; BRCA cis rs10870270 1.000 rs11146338 chr10:133770291 C/G cg08754478 chr10:133766260 PPP2R2D -0.68 -14.11 -0.49 1.44e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12477438 0.520 rs11692699 chr2:99730657 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.08 0.74 1.26e-113 Chronic sinus infection; BRCA cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs6570726 0.905 rs442435 chr6:145815559 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.31 0.49 1.72e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs2625529 0.775 rs16956273 chr15:72117102 C/T cg16672083 chr15:72433130 SENP8 -0.7 -16.11 -0.54 3.09e-49 Red blood cell count; BRCA cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg19077165 chr18:44547161 KATNAL2 0.37 8.0 0.3 5.68e-15 Personality dimensions; BRCA trans rs3780486 0.846 rs7864705 chr9:33140352 A/C cg20290983 chr6:43655470 MRPS18A 1.11 41.24 0.85 2.93e-182 IgG glycosylation; BRCA cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg18132916 chr6:79620363 NA -0.4 -8.09 -0.3 2.94e-15 Intelligence (multi-trait analysis); BRCA trans rs877282 1.000 rs112522746 chr10:772288 T/C cg22713356 chr15:30763199 NA 1.19 24.18 0.69 3.39e-92 Uric acid levels; BRCA cis rs3739998 0.527 rs4749524 chr10:30332618 G/C cg00730780 chr10:30316187 KIAA1462 0.56 10.99 0.4 7.22e-26 Coronary heart disease; BRCA cis rs17685 0.725 rs7807647 chr7:75628669 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.38 8.5 0.32 1.31e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs16976116 0.901 rs73409853 chr15:55502681 A/T cg11288833 chr15:55489084 RSL24D1 0.47 10.64 0.39 1.87e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10046574 0.831 rs75959757 chr7:135170755 G/A cg27474649 chr7:135195673 CNOT4 0.61 8.47 0.32 1.65e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6964587 0.967 rs28615927 chr7:91600648 C/A cg17063962 chr7:91808500 NA 0.53 12.53 0.44 2.32e-32 Breast cancer; BRCA cis rs854572 0.600 rs705382 chr7:94955221 C/G cg04155289 chr7:94953770 PON1 -0.43 -9.01 -0.34 2.41e-18 Paraoxonase activity; BRCA cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg20503657 chr10:835505 NA 0.84 15.27 0.52 4.37e-45 Eosinophil percentage of granulocytes; BRCA cis rs757278 0.646 rs11768272 chr7:117347082 G/A cg10524701 chr7:117356490 CTTNBP2 0.42 7.85 0.3 1.81e-14 Response to methotrexate in juvenile idiopathic arthritis; BRCA cis rs17401966 0.931 rs2276100 chr1:10394536 C/G cg03954927 chr1:10346856 KIF1B 0.48 15.23 0.52 6.45e-45 Hepatocellular carcinoma; BRCA cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg02187348 chr16:89574699 SPG7 -0.34 -7.96 -0.3 7.62e-15 Multiple myeloma (IgH translocation); BRCA cis rs910316 0.737 rs175080 chr14:75513828 G/A cg08847533 chr14:75593920 NEK9 -0.81 -19.39 -0.61 3.22e-66 Height; BRCA cis rs432925 0.600 rs214247 chr16:349221 A/G cg06233593 chr16:337645 AXIN1 0.44 10.92 0.4 1.49e-25 Morning vs. evening chronotype; BRCA cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg22974920 chr21:40686053 BRWD1 -0.35 -7.93 -0.3 1.01e-14 Menarche (age at onset); BRCA trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21659725 chr3:3221576 CRBN -0.45 -11.46 -0.41 8.87e-28 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg04944784 chr2:26401820 FAM59B 0.9 15.82 0.53 7.91e-48 Gut microbiome composition (summer); BRCA cis rs11190604 1.000 rs2489053 chr10:102353341 A/G cg07080220 chr10:102295463 HIF1AN 0.47 10.75 0.39 6.63e-25 Palmitoleic acid (16:1n-7) levels; BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg12444411 chr7:2802554 GNA12 -0.33 -8.26 -0.31 8.12e-16 Height; BRCA trans rs6951245 1.000 rs76388414 chr7:1100694 G/A cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.52e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg07395648 chr5:131743802 NA 0.36 7.99 0.3 6.12e-15 Acylcarnitine levels; BRCA cis rs9467773 0.935 rs1056668 chr6:26510605 C/T cg09904177 chr6:26538194 HMGN4 0.52 15.0 0.51 8.16e-44 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg06494592 chr3:125709126 NA -0.54 -8.44 -0.32 2.09e-16 Blood pressure (smoking interaction); BRCA cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg11742103 chr11:62369870 EML3;MTA2 0.54 13.37 0.47 3.9e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7726839 0.561 rs56410216 chr5:583216 C/A cg09021430 chr5:549028 NA -0.64 -15.31 -0.52 2.54e-45 Obesity-related traits; BRCA cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg21489266 chr3:46619131 LRRC2;TDGF1 -0.33 -8.57 -0.32 7.57e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.59 -0.42 2.52e-28 Lymphocyte counts; BRCA cis rs2637266 1.000 rs1907319 chr10:78337049 A/G cg18941641 chr10:78392320 NA -0.35 -7.83 -0.3 1.98e-14 Pulmonary function; BRCA cis rs1949733 1.000 rs2688233 chr4:8491885 T/C cg11789530 chr4:8429930 ACOX3 0.68 17.62 0.57 6.01e-57 Response to antineoplastic agents; BRCA cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.71 -10.4 -0.38 1.7e-23 Schizophrenia; BRCA cis rs4803468 0.967 rs16975238 chr19:41944985 T/A cg09537434 chr19:41945824 ATP5SL 1.03 25.66 0.71 2.48e-100 Height; BRCA cis rs7131987 0.903 rs2194519 chr12:29423583 C/T cg09582351 chr12:29534625 ERGIC2 0.48 11.68 0.42 1.04e-28 QT interval; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg04013093 chr6:42928303 GNMT -0.27 -8.48 -0.32 1.59e-16 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs853679 0.546 rs200952 chr6:27836976 C/T cg26587870 chr6:27730563 NA -0.55 -8.23 -0.31 1.08e-15 Depression; BRCA cis rs7647973 0.667 rs6446286 chr3:49681704 A/G cg07636037 chr3:49044803 WDR6 0.52 8.46 0.32 1.81e-16 Menarche (age at onset); BRCA cis rs2635047 0.967 rs2571001 chr18:44665083 C/A cg19077165 chr18:44547161 KATNAL2 -0.4 -8.47 -0.32 1.64e-16 Educational attainment; BRCA trans rs2018683 1.000 rs2018683 chr7:29014195 G/T cg19402173 chr7:128379420 CALU -0.56 -14.03 -0.49 3.69e-39 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA trans rs6089829 0.962 rs6089824 chr20:61659207 A/G cg17470723 chr8:74884337 TCEB1 0.41 8.64 0.32 4.33e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2795502 0.882 rs3123754 chr10:43339011 G/A cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg10295955 chr4:187884368 NA -0.99 -31.58 -0.78 1.4e-132 Lobe attachment (rater-scored or self-reported); BRCA cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg05868516 chr6:26286170 HIST1H4H 0.5 10.87 0.4 2.27e-25 Educational attainment; BRCA cis rs11191205 0.644 rs11191061 chr10:103366069 T/C cg15320455 chr10:103880129 LDB1 0.47 8.09 0.3 2.92e-15 Intelligence (multi-trait analysis); BRCA cis rs16958440 0.708 rs1434528 chr18:44632323 G/A cg17192377 chr18:44677553 HDHD2 0.48 8.0 0.3 5.82e-15 Sitting height ratio; BRCA cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.11 0.34 1.09e-18 Motion sickness; BRCA cis rs6831352 0.918 rs28987088 chr4:100059139 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg09436375 chr6:42928200 GNMT -0.3 -10.85 -0.39 2.75e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7312933 0.703 rs10880268 chr12:42599122 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -9.24 -0.34 3.48e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs3849570 0.925 rs6798680 chr3:81905441 C/A cg07356753 chr3:81810745 GBE1 -0.43 -10.25 -0.38 6.45e-23 Waist circumference;Body mass index; BRCA trans rs9397585 0.599 rs685826 chr6:153411255 C/T cg26642667 chr7:127292389 SND1 0.43 7.93 0.3 9.82e-15 Body mass index; BRCA cis rs6456156 0.583 rs7748224 chr6:167456860 C/T cg07741184 chr6:167504864 NA 0.33 9.65 0.36 1.17e-20 Primary biliary cholangitis; BRCA cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg21138405 chr5:131827807 IRF1 0.39 11.74 0.42 6.16e-29 Asthma (sex interaction); BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg14863265 chr7:2801509 GNA12 0.42 9.21 0.34 4.78e-19 Height; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg09877947 chr5:131593287 PDLIM4 0.46 11.17 0.4 1.37e-26 Acylcarnitine levels; BRCA cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg17063962 chr7:91808500 NA 0.54 12.8 0.45 1.56e-33 Breast cancer; BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg08470875 chr2:26401718 FAM59B 0.77 11.95 0.43 7.53e-30 Gut microbiome composition (summer); BRCA cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg26031613 chr14:104095156 KLC1 -0.53 -9.38 -0.35 1.11e-19 Reticulocyte count; BRCA cis rs2280018 0.963 rs4985147 chr16:15168760 T/C cg27102117 chr16:15229624 NA 0.33 8.18 0.31 1.58e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1468333 1.000 rs217274 chr5:137490974 A/G cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.5 0.32 1.35e-16 Resting heart rate; BRCA cis rs2180341 0.883 rs6904630 chr6:127696869 A/G cg27446573 chr6:127587934 RNF146 0.89 20.42 0.63 1e-71 Breast cancer; BRCA cis rs826838 0.874 rs11183816 chr12:38834656 T/G cg13010199 chr12:38710504 ALG10B 0.55 11.92 0.43 1e-29 Heart rate; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.33 0.35 1.64e-19 Tonsillectomy; BRCA cis rs13136331 0.680 rs2732171 chr4:88655984 A/G cg22416721 chr4:88570574 DMP1 -0.56 -13.49 -0.47 1.15e-36 Sitting height ratio; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg26314531 chr2:26401878 FAM59B 0.96 16.52 0.55 2.62e-51 Gut microbiome composition (summer); BRCA cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.14 0.4 1.9e-26 IgG glycosylation; BRCA cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg20503657 chr10:835505 NA -0.54 -10.08 -0.37 2.87e-22 Response to angiotensin II receptor blocker therapy; BRCA cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg24578937 chr1:2090814 PRKCZ 0.34 10.78 0.39 5.16e-25 Height; BRCA cis rs4561483 0.801 rs33643 chr16:11986149 A/G cg08843971 chr16:11963173 GSPT1 -0.54 -12.21 -0.44 5.56e-31 Testicular germ cell tumor; BRCA cis rs1401999 0.606 rs939335 chr3:183745663 A/G cg01324343 chr3:183735012 ABCC5 0.7 16.49 0.55 3.68e-51 Anterior chamber depth; BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg13047869 chr3:10149882 C3orf24 0.54 11.36 0.41 2.28e-27 Alzheimer's disease; BRCA cis rs11098499 0.645 rs78422072 chr4:120281042 C/T cg09307838 chr4:120376055 NA 0.64 13.3 0.47 8.45e-36 Corneal astigmatism; BRCA cis rs7095944 0.582 rs2303611 chr10:126517989 G/A cg08799069 chr10:126477246 METTL10 -0.38 -9.12 -0.34 9.67e-19 Asthma; BRCA cis rs2635047 0.967 rs2576060 chr18:44637106 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.4 -8.83 -0.33 9.83e-18 Educational attainment; BRCA cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg24531977 chr5:56204891 C5orf35 -0.72 -16.11 -0.54 2.79e-49 Initial pursuit acceleration; BRCA cis rs701145 0.878 rs355760 chr3:154009933 T/C cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs7789940 1.000 rs2072435 chr7:75959188 G/A cg10167463 chr7:75959203 YWHAG -0.44 -8.93 -0.33 4.67e-18 Multiple sclerosis; BRCA cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -8.98 -0.33 3.08e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg25554036 chr4:6271136 WFS1 0.42 9.98 0.37 6.9e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1008375 0.646 rs13103430 chr4:17567355 A/C cg16339924 chr4:17578868 LAP3 -0.48 -10.95 -0.4 1.04e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7647973 0.710 rs11130208 chr3:49615624 G/T cg07636037 chr3:49044803 WDR6 0.55 8.7 0.33 2.75e-17 Menarche (age at onset); BRCA cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg00651523 chr6:28411279 ZSCAN23 -0.37 -8.03 -0.3 4.72e-15 Pubertal anthropometrics; BRCA cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.19 -0.4 1.19e-26 Extrinsic epigenetic age acceleration; BRCA cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.7 0.76 1.93e-122 Cognitive function; BRCA trans rs12310956 0.532 rs35366144 chr12:33992000 C/G cg26384229 chr12:38710491 ALG10B 0.67 14.01 0.48 4.18e-39 Morning vs. evening chronotype; BRCA cis rs12474201 0.963 rs3829835 chr2:46925789 C/T cg06386533 chr2:46925753 SOCS5 0.87 18.88 0.6 1.54e-63 Height; BRCA cis rs7927771 0.864 rs2053979 chr11:47439444 A/G cg20307385 chr11:47447363 PSMC3 -0.43 -9.1 -0.34 1.14e-18 Subjective well-being; BRCA cis rs425277 0.606 rs262669 chr1:2082489 A/G cg19257562 chr1:2043853 PRKCZ 0.34 9.05 0.34 1.71e-18 Height; BRCA cis rs4481887 1.000 rs4360555 chr1:248468591 G/T cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg12292205 chr6:26970375 C6orf41 0.64 14.57 0.5 1.04e-41 Autism spectrum disorder or schizophrenia; BRCA cis rs7408868 1.000 rs2074622 chr19:15277620 G/C cg14696996 chr19:15285081 NOTCH3 1.01 14.77 0.5 1.08e-42 Pulse pressure; BRCA cis rs7267979 0.714 rs1555329 chr20:25231858 G/A cg08601574 chr20:25228251 PYGB 0.34 8.21 0.31 1.19e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs782590 0.902 rs782602 chr2:55849309 A/G cg18811423 chr2:55921094 PNPT1 0.7 22.07 0.66 1.22e-80 Metabolic syndrome; BRCA cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.45 -0.38 1.08e-23 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.37e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg12564285 chr5:131593104 PDLIM4 0.36 9.65 0.36 1.12e-20 Breast cancer; BRCA cis rs13217239 0.646 rs12523820 chr6:27001502 A/G cg12292205 chr6:26970375 C6orf41 0.58 13.03 0.46 1.32e-34 Schizophrenia; BRCA cis rs600806 0.888 rs3853498 chr1:109860144 T/C cg20591472 chr1:110008990 SYPL2 0.32 8.14 0.31 2.09e-15 Intelligence (multi-trait analysis); BRCA cis rs28602670 1 rs28602670 chr15:78768167 C/G cg24631222 chr15:78858424 CHRNA5 0.49 9.67 0.36 1e-20 Post bronchodilator FEV1; BRCA cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.47 -0.5 3.03e-41 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.07e-15 Depression; BRCA cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg06494592 chr3:125709126 NA -0.49 -8.16 -0.31 1.75e-15 Blood pressure (smoking interaction); BRCA cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg14440974 chr22:39074834 NA -0.39 -8.93 -0.33 4.37e-18 Menopause (age at onset); BRCA cis rs2859741 0.546 rs2102087 chr1:37482849 G/A cg09363841 chr1:37513479 NA -0.51 -11.17 -0.4 1.32e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs10193935 1.000 rs10171023 chr2:42407093 G/C cg27598129 chr2:42591480 NA -0.88 -14.09 -0.49 1.84e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs743757 1.000 rs2282754 chr3:50436827 T/C cg08207895 chr3:50388901 TUSC4;CYB561D2 0.37 8.86 0.33 7.7e-18 Diastolic blood pressure; BRCA cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.54 -0.44 2.04e-32 Bipolar disorder; BRCA cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg19274703 chr22:41806451 NA 0.36 8.18 0.31 1.5e-15 Vitiligo; BRCA cis rs7631605 0.905 rs1392749 chr3:37205191 A/G cg15934958 chr3:37212084 LRRFIP2 -0.42 -9.8 -0.36 3.1e-21 Cerebrospinal P-tau181p levels; BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.23 -0.44 4.83e-31 Gut microbiome composition (summer); BRCA cis rs6942756 1.000 rs67997229 chr7:128957366 G/C cg02491457 chr7:128862824 NA -0.71 -13.92 -0.48 1.12e-38 White matter hyperintensity burden; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg06618935 chr21:46677482 NA -0.37 -7.94 -0.3 9e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg03929089 chr4:120376271 NA -0.98 -29.5 -0.76 2.38e-121 Height; BRCA cis rs7975161 0.520 rs4502051 chr12:104695569 A/T cg25273343 chr12:104657179 TXNRD1 -0.56 -9.04 -0.34 1.89e-18 Toenail selenium levels; BRCA trans rs2832077 0.527 rs9980449 chr21:30224889 G/C cg14791747 chr16:20752902 THUMPD1 0.45 14.24 0.49 3.71e-40 Cognitive test performance; BRCA cis rs7829975 0.606 rs6422352 chr8:8794193 A/G cg15556689 chr8:8085844 FLJ10661 -0.42 -11.45 -0.41 9.31e-28 Mood instability; BRCA cis rs9304742 0.962 rs12459008 chr19:53454789 A/T cg09915433 chr19:53449742 NA 0.73 16.71 0.55 2.68e-52 Psoriasis; BRCA cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.75e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7539409 1.000 rs7539409 chr1:84254735 A/G cg10977910 chr1:84465055 TTLL7 -0.66 -8.59 -0.32 6.83e-17 Alzheimer's disease; BRCA cis rs4820294 0.669 rs9622677 chr22:38054262 A/C cg21798802 chr22:38057573 PDXP 0.29 7.84 0.3 1.93e-14 Fat distribution (HIV); BRCA cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg13319975 chr6:146136371 FBXO30 0.41 9.29 0.34 2.42e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 1.000 rs3749591 chr4:120214030 T/G cg25214090 chr10:38739885 LOC399744 0.51 10.68 0.39 1.3e-24 Corneal astigmatism; BRCA cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg26818010 chr10:134567672 INPP5A -0.78 -15.37 -0.52 1.39e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs7824557 0.933 rs6601576 chr8:11100275 A/T cg15556689 chr8:8085844 FLJ10661 -0.35 -8.5 -0.32 1.37e-16 Retinal vascular caliber; BRCA cis rs6545883 0.839 rs778764 chr2:61785680 C/T cg15711740 chr2:61764176 XPO1 -0.46 -11.36 -0.41 2.19e-27 Tuberculosis; BRCA cis rs10883723 0.810 rs2296586 chr10:104245575 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.27 0.63 6.19e-71 Allergic disease (asthma, hay fever or eczema); BRCA cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg16414030 chr3:133502952 NA -0.47 -10.95 -0.4 1.12e-25 Iron status biomarkers; BRCA trans rs6479891 1.000 rs4746974 chr10:64892052 G/T cg14819942 chr15:35414228 NA 0.34 8.39 0.32 3.02e-16 Arthritis (juvenile idiopathic); BRCA cis rs6121246 0.909 rs1075698 chr20:30387992 G/C cg21427119 chr20:30132790 HM13 -0.42 -8.89 -0.33 6.37e-18 Mean corpuscular hemoglobin; BRCA trans rs6952808 0.630 rs10239050 chr7:2158390 A/G cg04565464 chr8:145669602 NFKBIL2 0.37 8.7 0.33 2.82e-17 Bipolar disorder and schizophrenia; BRCA cis rs4930561 0.739 rs12225316 chr11:67976003 T/C cg16338278 chr11:67432957 ALDH3B2 0.44 8.86 0.33 7.81e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg25767906 chr1:53392781 SCP2 -0.39 -8.49 -0.32 1.47e-16 Monocyte count; BRCA cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg20362242 chr5:692897 TPPP 0.53 8.0 0.3 5.8e-15 Lung disease severity in cystic fibrosis; BRCA cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.36e-31 Bipolar disorder; BRCA cis rs8180040 0.739 rs11719306 chr3:47184182 G/A cg16586182 chr3:47516702 SCAP -0.56 -12.82 -0.45 1.23e-33 Colorectal cancer; BRCA trans rs8062405 0.824 rs28698667 chr16:28533071 C/T cg09719594 chr16:21412588 NA -0.35 -8.36 -0.31 3.87e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.37e-15 Menopause (age at onset); BRCA cis rs3135071 1.000 rs3135071 chr4:2406321 C/T cg01601518 chr4:2404284 ZFYVE28 0.54 8.7 0.33 2.83e-17 Influenza A (H1N1) severity; BRCA cis rs919433 0.680 rs11680291 chr2:198409884 A/G cg00792783 chr2:198669748 PLCL1 0.34 7.9 0.3 1.2e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9858542 1.000 rs9822268 chr3:49719729 G/A cg03060546 chr3:49711283 APEH -0.58 -11.74 -0.42 5.82e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg23711669 chr6:146136114 FBXO30 -0.68 -15.4 -0.52 1.02e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs1941023 0.503 rs2233238 chr11:60145441 G/C cg08716584 chr11:60157161 MS4A7 -0.43 -10.37 -0.38 2.17e-23 Congenital heart disease (maternal effect); BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg05279229 chr7:1896384 MAD1L1 -0.41 -7.85 -0.3 1.73e-14 Bipolar disorder and schizophrenia; BRCA cis rs732716 0.504 rs9352 chr19:4442336 C/T cg24019073 chr19:4448726 UBXN6 0.36 8.59 0.32 6.63e-17 Mean corpuscular volume; BRCA cis rs62229266 0.804 rs62230821 chr21:37425116 C/T cg12218747 chr21:37451666 NA -0.33 -7.94 -0.3 9.24e-15 Mitral valve prolapse; BRCA cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg18196295 chr10:418757 DIP2C -0.48 -11.55 -0.42 3.6e-28 Psychosis in Alzheimer's disease; BRCA cis rs34779708 0.966 rs12769484 chr10:35465746 G/A cg03585969 chr10:35415529 CREM 0.56 11.68 0.42 1.08e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6061231 0.837 rs6121558 chr20:60961365 A/G cg24112000 chr20:60950667 NA -0.55 -11.01 -0.4 5.98e-26 Colorectal cancer; BRCA cis rs3845702 0.668 rs12693215 chr2:180826007 A/C cg01881094 chr2:180872142 CWC22 -0.96 -17.33 -0.57 2.01e-55 Schizophrenia; BRCA cis rs9457247 0.602 rs2157388 chr6:167481912 G/A cg07741184 chr6:167504864 NA 0.37 10.6 0.39 2.7e-24 Crohn's disease; BRCA cis rs2242116 0.796 rs9852082 chr3:46972377 T/C cg27129171 chr3:47204927 SETD2 0.66 14.27 0.49 2.65e-40 Birth weight; BRCA cis rs2625529 0.556 rs1552134 chr15:72232898 T/A cg16672083 chr15:72433130 SENP8 0.67 15.81 0.53 9.1e-48 Red blood cell count; BRCA cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.36 -0.52 1.43e-45 Breast cancer; BRCA cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.97 -0.3 7.2e-15 Ulcerative colitis; BRCA cis rs13191362 0.872 rs56404230 chr6:163252863 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.64 9.75 0.36 4.83e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10845606 1.000 rs10845606 chr12:12834894 G/T cg09462578 chr12:12878428 APOLD1 -0.63 -11.12 -0.4 2.13e-26 Systemic lupus erythematosus; BRCA trans rs208515 0.556 rs10455193 chr6:66691456 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 16.04 0.54 6.65e-49 Exhaled nitric oxide levels; BRCA cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg20503657 chr10:835505 NA -0.53 -9.67 -0.36 1.01e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs738321 0.725 rs5756926 chr22:38542613 T/C cg25457927 chr22:38595422 NA -0.36 -12.62 -0.45 9.31e-33 Breast cancer; BRCA cis rs12541635 0.934 rs11776139 chr8:106983966 A/G cg10147462 chr8:107024639 NA 0.37 9.86 0.36 1.97e-21 Age of smoking initiation; BRCA cis rs2070488 1.000 rs1002675 chr3:38445226 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.68 18.83 0.6 3.08e-63 Electrocardiographic conduction measures; BRCA cis rs7572733 0.534 rs700688 chr2:198723833 A/G cg00792783 chr2:198669748 PLCL1 -0.46 -10.2 -0.37 9.58e-23 Dermatomyositis; BRCA cis rs67311347 0.544 rs2123998 chr3:40359005 C/G cg09455208 chr3:40491958 NA -0.32 -7.84 -0.3 1.85e-14 Renal cell carcinoma; BRCA cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.31 0.47 7.47e-36 Schizophrenia; BRCA cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.09 0.4 2.82e-26 Electroencephalogram traits; BRCA cis rs56399783 0.901 rs11764225 chr7:2775607 G/A cg19731401 chr7:2775893 GNA12 0.49 7.95 0.3 8.57e-15 Childhood ear infection; BRCA cis rs12479064 0.724 rs112900993 chr2:99948805 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -11.95 -0.43 7.82e-30 Chronic sinus infection; BRCA cis rs9393692 0.676 rs806977 chr6:26189615 A/G cg13736514 chr6:26305472 NA -0.33 -10.27 -0.38 5.31e-23 Educational attainment; BRCA cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg15017067 chr4:17643749 FAM184B 0.3 9.07 0.34 1.49e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1801251 0.893 rs6733151 chr2:233592341 A/C cg08000102 chr2:233561755 GIGYF2 0.63 13.89 0.48 1.59e-38 Coronary artery disease; BRCA cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg03146154 chr1:46216737 IPP -0.49 -10.82 -0.39 3.59e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9393777 0.588 rs11967935 chr6:26560672 A/C cg12292205 chr6:26970375 C6orf41 -0.5 -8.56 -0.32 8.67e-17 Intelligence (multi-trait analysis); BRCA trans rs6076960 0.846 rs6053962 chr20:6176915 A/G cg17788362 chr6:86352627 SYNCRIP 0.38 8.28 0.31 7.16e-16 Smooth-surface caries; BRCA cis rs950169 0.614 rs12903883 chr15:84680553 A/G cg17507749 chr15:85114479 UBE2QP1 0.55 9.17 0.34 6.21e-19 Schizophrenia; BRCA cis rs30380 0.632 rs26491 chr5:96134113 A/G cg16492584 chr5:96139282 ERAP1 -0.47 -10.94 -0.4 1.2e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg06784218 chr1:46089804 CCDC17 0.47 11.25 0.41 6.68e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3806843 0.766 rs702397 chr5:140050265 A/G cg16179182 chr5:140090404 VTRNA1-1 0.42 9.69 0.36 7.96e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg21724239 chr8:58056113 NA -0.61 -9.94 -0.37 9.66e-22 Developmental language disorder (linguistic errors); BRCA cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 8.97 0.33 3.38e-18 Renal function-related traits (BUN); BRCA cis rs6088580 0.524 rs6088565 chr20:33254986 A/C cg24642439 chr20:33292090 TP53INP2 -0.45 -8.46 -0.32 1.83e-16 Glomerular filtration rate (creatinine); BRCA cis rs11229555 0.645 rs11229450 chr11:58201629 G/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7520050 0.645 rs1768809 chr1:46502836 A/C cg06784218 chr1:46089804 CCDC17 -0.35 -8.79 -0.33 1.35e-17 Red blood cell count;Reticulocyte count; BRCA cis rs7131987 0.683 rs3782511 chr12:29496224 G/A cg09582351 chr12:29534625 ERGIC2 -0.48 -10.89 -0.4 1.84e-25 QT interval; BRCA cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg26647111 chr11:31128758 NA -0.45 -9.74 -0.36 5.44e-21 Red blood cell count; BRCA cis rs1003719 0.715 rs2835659 chr21:38567902 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.5 -0.5 2.11e-41 Eye color traits; BRCA cis rs11098499 0.954 rs12505469 chr4:120249585 C/T cg09307838 chr4:120376055 NA 0.7 14.64 0.5 4.77e-42 Corneal astigmatism; BRCA cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.14 0.43 1.11e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs739401 0.572 rs739400 chr11:3016520 G/A cg25174290 chr11:3078921 CARS 0.41 12.46 0.44 4.91e-32 Longevity; BRCA cis rs28830936 0.966 rs17678552 chr15:42066190 T/C cg17847044 chr15:42102381 MAPKBP1 -0.37 -10.58 -0.39 3.35e-24 Diastolic blood pressure; BRCA cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg08999081 chr20:33150536 PIGU -0.32 -8.12 -0.31 2.34e-15 Glomerular filtration rate (creatinine); BRCA cis rs17401966 1.000 rs7520651 chr1:10329872 G/A cg15208524 chr1:10270712 KIF1B 0.37 8.05 0.3 3.97e-15 Hepatocellular carcinoma; BRCA cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg23109721 chr2:106886537 NA -0.46 -8.34 -0.31 4.6e-16 Facial morphology (factor 23); BRCA cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.41 0.32 2.61e-16 Bladder cancer; BRCA cis rs13315871 0.929 rs71311852 chr3:58298843 G/A cg20936604 chr3:58311152 NA -0.66 -8.41 -0.32 2.59e-16 Cholesterol, total; BRCA cis rs589448 0.900 rs588493 chr12:69751986 G/A cg14784868 chr12:69753453 YEATS4 0.78 25.0 0.7 9.83e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg03709012 chr19:19516395 GATAD2A 0.81 19.13 0.6 8.08e-65 Tonsillectomy; BRCA cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg05639522 chr1:247681581 NA 0.47 10.61 0.39 2.39e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs56804039 1.000 rs59620654 chr8:8382632 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -9.25 -0.34 3.36e-19 Cervical cancer; BRCA cis rs9311474 1.000 rs9311474 chr3:52338852 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.36 -8.01 -0.3 5.53e-15 Electroencephalogram traits; BRCA cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg17971929 chr21:40555470 PSMG1 0.78 18.35 0.59 9.63e-61 Cognitive function; BRCA cis rs9811920 0.609 rs793465 chr3:99627750 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.13 0.31 2.22e-15 Depression; BRCA cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.45 -0.47 1.68e-36 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.704 rs2888600 chr7:148908562 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 8.46 0.32 1.86e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.64e-66 Mean platelet volume; BRCA cis rs12579753 0.879 rs11115010 chr12:82165895 G/T cg07988820 chr12:82153109 PPFIA2 -0.65 -10.97 -0.4 8.6e-26 Resting heart rate; BRCA cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg20503657 chr10:835505 NA 1.03 18.21 0.58 5.62e-60 Eosinophil percentage of granulocytes; BRCA cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg13010199 chr12:38710504 ALG10B 0.52 10.81 0.39 3.81e-25 Drug-induced liver injury (flucloxacillin); BRCA trans rs11098499 0.780 rs10013652 chr4:120292256 A/G cg25214090 chr10:38739885 LOC399744 0.49 11.27 0.41 5.2e-27 Corneal astigmatism; BRCA cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg24069376 chr3:38537580 EXOG -0.31 -8.94 -0.33 4.32e-18 Electrocardiographic conduction measures; BRCA cis rs250677 0.522 rs10045726 chr5:148352990 C/T cg18129178 chr5:148520854 ABLIM3 0.54 10.52 0.38 5.62e-24 Breast cancer; BRCA cis rs8062405 1.000 rs62037371 chr16:28890131 C/A cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs13102973 0.965 rs6535050 chr4:135874115 A/C cg14419869 chr4:135874104 NA -0.59 -12.98 -0.46 2.33e-34 Subjective well-being; BRCA cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.64 -0.32 4.41e-17 Bipolar disorder; BRCA cis rs933688 1.000 rs1035477 chr5:90743325 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.1 0.62 5.33e-70 Smoking behavior; BRCA cis rs9400271 0.609 rs9386782 chr6:109588643 G/T cg21918786 chr6:109611834 NA -0.32 -8.09 -0.3 3.08e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 14.28 0.49 2.44e-40 Alzheimer's disease; BRCA cis rs4595586 0.545 rs12812959 chr12:39371197 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.27 0.34 2.78e-19 Morning vs. evening chronotype; BRCA cis rs597539 0.652 rs686877 chr11:68637169 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.63 0.55 7.04e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA trans rs7824557 0.836 rs2736378 chr8:11119760 G/A cg15556689 chr8:8085844 FLJ10661 -0.41 -9.77 -0.36 4.16e-21 Retinal vascular caliber; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg14863265 chr7:2801509 GNA12 -0.41 -8.99 -0.33 2.87e-18 Height; BRCA cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg16414030 chr3:133502952 NA -0.49 -11.37 -0.41 2.1e-27 Iron status biomarkers; BRCA cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs812925 0.533 rs60997156 chr2:61396539 T/A cg15711740 chr2:61764176 XPO1 -0.32 -7.85 -0.3 1.73e-14 Immature fraction of reticulocytes; BRCA cis rs12579753 1.000 rs7963577 chr12:82174115 T/C cg07988820 chr12:82153109 PPFIA2 -0.59 -9.51 -0.35 3.9e-20 Resting heart rate; BRCA trans rs853679 0.607 rs13190888 chr6:28285985 G/A cg06606381 chr12:133084897 FBRSL1 -0.85 -8.84 -0.33 9.03e-18 Depression; BRCA cis rs11252926 0.617 rs11253319 chr10:722732 C/T cg08603382 chr10:743973 NA -0.54 -10.21 -0.37 9.2e-23 Psychosis in Alzheimer's disease; BRCA cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg14255062 chr9:123606675 PSMD5;LOC253039 -0.31 -8.67 -0.32 3.63e-17 Birth weight; BRCA cis rs1800682 0.528 rs3903454 chr10:90743434 A/T cg03111039 chr10:90751583 FAS;ACTA2 0.53 12.36 0.44 1.34e-31 Chronic lymphocytic leukemia; BRCA cis rs4319547 0.695 rs6489002 chr12:122929822 T/C cg23029597 chr12:123009494 RSRC2 -0.61 -11.81 -0.42 3e-29 Body mass index; BRCA cis rs9612 0.718 rs346536 chr19:44251470 A/T cg08581076 chr19:44259116 C19orf61 0.44 7.99 0.3 6.16e-15 Exhaled nitric oxide output; BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg00149659 chr3:10157352 C3orf10 1.07 18.04 0.58 4.24e-59 Alzheimer's disease; BRCA trans rs561341 1.000 rs55978022 chr17:30275937 T/C cg27661571 chr11:113659931 NA -0.82 -12.27 -0.44 3.32e-31 Hip circumference adjusted for BMI; BRCA cis rs4808199 0.895 rs8105984 chr19:19374068 T/C cg03709012 chr19:19516395 GATAD2A 0.95 15.92 0.53 2.49e-48 Nonalcoholic fatty liver disease; BRCA cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg13010199 chr12:38710504 ALG10B 0.51 10.44 0.38 1.19e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.13 0.4 2.07e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.55 9.22 0.34 4.22e-19 Renal function-related traits (BUN); BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg13397359 chr6:42928475 GNMT -0.66 -16.02 -0.54 8.01e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg26818010 chr10:134567672 INPP5A -0.79 -16.05 -0.54 5.93e-49 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6582630 0.555 rs10785454 chr12:38476260 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs9814567 1.000 rs4535272 chr3:134299916 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.81e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 4.98e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs9393777 0.920 rs34071253 chr6:27391802 C/T cg01620082 chr3:125678407 NA -0.68 -9.17 -0.34 6.52e-19 Intelligence (multi-trait analysis); BRCA cis rs7524258 0.868 rs1304712 chr1:7270538 C/T cg07173049 chr1:7289937 CAMTA1 0.45 10.92 0.4 1.43e-25 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.71 -0.36 6.84e-21 Menopause (age at onset); BRCA cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg19077165 chr18:44547161 KATNAL2 -0.5 -10.78 -0.39 5.25e-25 Personality dimensions; BRCA cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.23e-36 Developmental language disorder (linguistic errors); BRCA cis rs11229555 0.874 rs11605269 chr11:58350872 A/G cg15696309 chr11:58395628 NA -0.54 -11.75 -0.42 5.45e-29 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs651907 0.535 rs9830943 chr3:101428899 T/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 13.87 0.48 2.04e-38 Colorectal cancer; BRCA cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.47 0.38 9.17e-24 Motion sickness; BRCA cis rs7264396 0.747 rs73283043 chr20:34383863 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.65 -0.53 5.84e-47 Total cholesterol levels; BRCA trans rs3857536 0.776 rs2040593 chr6:66944076 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.99 -0.3 6.35e-15 Blood trace element (Cu levels); BRCA cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.51 -0.41 5.7e-28 Electroencephalogram traits; BRCA cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.29e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs208346 1.000 rs208346 chr7:2799686 G/T cg19717773 chr7:2847554 GNA12 0.41 8.95 0.33 3.82e-18 Loneliness (linear analysis); BRCA cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg19901468 chr14:105411992 AHNAK2 -0.51 -12.43 -0.44 6.12e-32 Rheumatoid arthritis; BRCA cis rs3806843 0.676 rs2563304 chr5:140072057 C/T cg16179182 chr5:140090404 VTRNA1-1 0.46 10.91 0.4 1.63e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs1577917 1.000 rs36096931 chr6:86693134 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.77 -0.42 4.5e-29 Response to antipsychotic treatment; BRCA cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.773 rs12536421 chr7:92008220 A/G cg17063962 chr7:91808500 NA 0.52 11.47 0.41 8.14e-28 Breast cancer; BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.26 -0.34 2.99e-19 Tonsillectomy; BRCA cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg18904891 chr8:8559673 CLDN23 0.65 12.88 0.45 6.52e-34 Obesity-related traits; BRCA trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg26384229 chr12:38710491 ALG10B 0.59 13.62 0.47 2.98e-37 Morning vs. evening chronotype; BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg02951883 chr7:2050386 MAD1L1 -0.41 -9.64 -0.36 1.27e-20 Bipolar disorder and schizophrenia; BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.73 -12.7 -0.45 3.91e-33 Platelet count; BRCA cis rs4363385 0.818 rs435633 chr1:153011811 A/G cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg20503657 chr10:835505 NA 0.9 13.91 0.48 1.26e-38 Eosinophil percentage of granulocytes; BRCA cis rs10463316 0.832 rs152087 chr5:150734419 C/T cg03212797 chr5:150827313 SLC36A1 -0.49 -9.0 -0.34 2.54e-18 Metabolite levels (Pyroglutamine); BRCA cis rs1994135 0.630 rs11052757 chr12:33719879 A/G cg06521331 chr12:34319734 NA -0.53 -9.32 -0.35 1.87e-19 Resting heart rate; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg21143896 chr7:2802374 GNA12 -0.37 -9.31 -0.35 2.06e-19 Height; BRCA cis rs72720396 0.694 rs6689362 chr1:91203251 T/A cg13456504 chr1:91191583 NA -0.39 -7.81 -0.3 2.3e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs2806561 0.695 rs66592286 chr1:23333649 G/C cg19743168 chr1:23544995 NA 0.34 7.86 0.3 1.65e-14 Height; BRCA cis rs899997 0.814 rs28661610 chr15:78985317 G/A cg04896959 chr15:78267971 NA -0.48 -11.16 -0.4 1.56e-26 Coronary artery disease or large artery stroke; BRCA cis rs10927875 0.518 rs732286 chr1:16344360 A/G cg06159980 chr1:16340746 HSPB7 -0.38 -8.74 -0.33 1.98e-17 Dilated cardiomyopathy; BRCA cis rs2882667 0.898 rs6867343 chr5:138374428 C/T cg04439458 chr5:138467593 SIL1 -0.33 -8.88 -0.33 6.67e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg14004847 chr7:1930337 MAD1L1 -0.46 -8.78 -0.33 1.47e-17 Bipolar disorder and schizophrenia; BRCA trans rs7647973 0.626 rs1996664 chr3:49878395 A/G cg21659725 chr3:3221576 CRBN 0.46 8.49 0.32 1.45e-16 Menarche (age at onset); BRCA cis rs7954584 0.531 rs1154514 chr12:122374888 C/T cg13699009 chr12:122356056 WDR66 0.34 7.87 0.3 1.49e-14 Mean corpuscular volume; BRCA trans rs61931739 0.926 rs13377754 chr12:34051765 T/C cg26384229 chr12:38710491 ALG10B -0.41 -9.17 -0.34 6.16e-19 Morning vs. evening chronotype; BRCA cis rs921968 0.541 rs581013 chr2:219432040 G/T cg02176678 chr2:219576539 TTLL4 0.46 12.21 0.43 5.86e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs6542838 0.611 rs7588441 chr2:99518858 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -8.91 -0.33 5.14e-18 Fear of minor pain; BRCA cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg27165867 chr14:105738592 BRF1 -0.35 -8.48 -0.32 1.56e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg09177884 chr7:1199841 ZFAND2A -0.59 -14.41 -0.5 5.53e-41 Longevity;Endometriosis; BRCA cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.9 -0.33 5.81e-18 Alzheimer's disease (late onset); BRCA cis rs28374715 0.783 rs11635269 chr15:41570710 A/G cg18705301 chr15:41695430 NDUFAF1 -1.0 -22.17 -0.66 3.38e-81 Ulcerative colitis; BRCA cis rs10751667 0.666 rs7396677 chr11:958878 C/T cg10932868 chr11:921992 NA 0.49 12.52 0.44 2.45e-32 Alzheimer's disease (late onset); BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg02951883 chr7:2050386 MAD1L1 -0.5 -10.8 -0.39 4.28e-25 Bipolar disorder and schizophrenia; BRCA cis rs9290065 0.519 rs7616249 chr3:160679422 T/C cg03342759 chr3:160939853 NMD3 -0.46 -9.45 -0.35 6.19e-20 Kawasaki disease; BRCA cis rs2421770 0.530 rs4756217 chr11:35366733 C/T cg13971030 chr11:35366721 SLC1A2 -0.45 -10.12 -0.37 1.9e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.23 0.49 4.09e-40 Motion sickness; BRCA cis rs35522438 1 rs35522438 chr7:91872872 A/AT cg17063962 chr7:91808500 NA 0.56 13.18 0.46 2.99e-35 Breast cancer; BRCA cis rs911555 0.692 rs7145753 chr14:103866100 G/A cg12935359 chr14:103987150 CKB 0.62 14.46 0.5 3.25e-41 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs62318906 chr4:99037110 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg08917208 chr2:24149416 ATAD2B 0.9 13.14 0.46 4.57e-35 Lymphocyte counts; BRCA cis rs9341808 0.718 rs4437429 chr6:80828592 A/G cg08355045 chr6:80787529 NA 0.37 9.37 0.35 1.19e-19 Sitting height ratio; BRCA cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg17971929 chr21:40555470 PSMG1 -0.77 -17.96 -0.58 1.03e-58 Cognitive function; BRCA trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg03929089 chr4:120376271 NA -0.47 -9.04 -0.34 1.9e-18 HDL cholesterol; BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00166722 chr3:10149974 C3orf24 0.56 11.16 0.4 1.5e-26 Alzheimer's disease; BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs826838 1.000 rs10880963 chr12:38748408 T/C cg13010199 chr12:38710504 ALG10B 0.56 12.23 0.44 4.73e-31 Heart rate; BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.51 7.83 0.3 1.97e-14 Renal function-related traits (BUN); BRCA cis rs10463316 0.894 rs7708499 chr5:150765906 A/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.29 -0.31 6.58e-16 Metabolite levels (Pyroglutamine); BRCA cis rs8180040 0.726 rs2305638 chr3:47046842 G/C cg27129171 chr3:47204927 SETD2 0.72 17.86 0.58 3.59e-58 Colorectal cancer; BRCA cis rs7267979 1.000 rs6107047 chr20:25442097 G/A cg08601574 chr20:25228251 PYGB 0.36 8.37 0.31 3.65e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.48 0.35 4.93e-20 Height; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg19626725 chr5:178986131 RUFY1 0.32 9.61 0.36 1.65e-20 Lung cancer; BRCA cis rs9486719 1.000 rs2472880 chr6:96860130 G/A cg06623918 chr6:96969491 KIAA0776 0.74 13.04 0.46 1.2e-34 Migraine;Coronary artery disease; BRCA cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg03213289 chr20:61660250 NA 0.62 16.39 0.54 1.23e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs7385804 0.796 rs10277087 chr7:100307538 C/G cg20848291 chr7:100343083 ZAN 0.36 8.23 0.31 1.02e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10465746 0.935 rs11580836 chr1:84333310 C/T cg10977910 chr1:84465055 TTLL7 0.5 10.17 0.37 1.29e-22 Obesity-related traits; BRCA cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 11.07 0.4 3.65e-26 Systemic lupus erythematosus; BRCA cis rs7264396 0.943 rs224431 chr20:34153599 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -9.39 -0.35 1e-19 Total cholesterol levels; BRCA cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg25554036 chr4:6271136 WFS1 0.42 9.91 0.37 1.21e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs747782 0.528 rs4370963 chr11:48433943 C/G cg15704280 chr7:45808275 SEPT13 0.55 8.22 0.31 1.18e-15 Intraocular pressure; BRCA cis rs11105298 0.891 rs6538189 chr12:89885923 C/A cg00757033 chr12:89920650 WDR51B 0.53 10.7 0.39 1.13e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs698833 0.926 rs1067406 chr2:44674450 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 9.05 0.34 1.69e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs12545109 0.800 rs1440762 chr8:57410708 C/T cg09654669 chr8:57350985 NA -0.39 -8.38 -0.31 3.5e-16 Obesity-related traits; BRCA cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs757110 0.866 rs5213 chr11:17408404 C/T cg03864215 chr11:17408437 KCNJ11 -0.29 -8.28 -0.31 7.09e-16 Type 2 diabetes; BRCA cis rs12621445 1 rs12621445 chr2:24154964 C/T cg08917208 chr2:24149416 ATAD2B 1.12 15.98 0.53 1.31e-48 Immature fraction of reticulocytes; BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -11.64 -0.42 1.62e-28 Alzheimer's disease; BRCA cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg17366294 chr4:99064904 C4orf37 0.41 9.33 0.35 1.72e-19 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.534 rs1705757 chr12:34091637 A/G cg13010199 chr12:38710504 ALG10B 0.4 8.08 0.3 3.21e-15 Morning vs. evening chronotype; BRCA trans rs35110281 0.667 rs7282405 chr21:45123611 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.8 0.33 1.25e-17 Mean corpuscular volume; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg11766577 chr21:47581405 C21orf56 -0.49 -10.89 -0.4 1.86e-25 Testicular germ cell tumor; BRCA cis rs7246657 0.678 rs2927740 chr19:38140966 A/G cg18154014 chr19:37997991 ZNF793 -0.48 -9.12 -0.34 9.67e-19 Coronary artery calcification; BRCA cis rs6878727 0.638 rs698180 chr5:123667977 T/G cg01806427 chr5:123737813 NA -0.37 -8.26 -0.31 8.69e-16 Breast cancer; BRCA cis rs870825 0.929 rs72689265 chr4:185590982 A/G cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs6952808 0.692 rs60755037 chr7:2030104 G/A cg04565464 chr8:145669602 NFKBIL2 0.38 8.93 0.33 4.59e-18 Bipolar disorder and schizophrenia; BRCA cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg14440974 chr22:39074834 NA -0.38 -8.97 -0.33 3.24e-18 Menopause (age at onset); BRCA cis rs2549003 0.966 rs10213701 chr5:131824064 T/A cg21138405 chr5:131827807 IRF1 0.38 11.61 0.42 2.06e-28 Asthma (sex interaction); BRCA cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg07148914 chr20:33460835 GGT7 0.36 7.94 0.3 9.13e-15 Height; BRCA cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA trans rs9858542 0.953 rs6997 chr3:49453834 C/T cg21659725 chr3:3221576 CRBN -0.47 -10.22 -0.37 8.03e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg26384229 chr12:38710491 ALG10B 0.75 16.51 0.55 2.8e-51 Morning vs. evening chronotype; BRCA cis rs9470361 0.524 rs7740181 chr6:36624111 C/T cg08179530 chr6:36648295 CDKN1A 0.38 8.17 0.31 1.65e-15 QRS complex (Cornell);QRS duration;Left ventricular fractional shortening; BRCA trans rs2270927 0.510 rs6891108 chr5:75579152 C/A cg13563193 chr19:33072644 PDCD5 0.88 10.28 0.38 4.77e-23 Mean corpuscular volume; BRCA trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg15556689 chr8:8085844 FLJ10661 0.41 10.88 0.4 2.09e-25 Neuroticism; BRCA cis rs7248779 1.000 rs7248779 chr19:2403564 G/T cg13499773 chr19:2433868 LMNB2 0.33 7.95 0.3 8.39e-15 Cortisol levels (saliva); BRCA cis rs3806843 0.741 rs4912597 chr5:140106857 C/G cg26395211 chr5:140044315 WDR55 0.38 8.55 0.32 9.05e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs8072100 1.000 rs4794016 chr17:45725931 T/A cg25173405 chr17:45401733 C17orf57 0.53 11.17 0.4 1.39e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg03477792 chr4:77819574 ANKRD56 0.6 14.03 0.49 3.58e-39 Emphysema distribution in smoking; BRCA trans rs11165623 0.585 rs55896436 chr1:96994162 G/A cg10631902 chr5:14652156 NA -0.43 -12.15 -0.43 1.09e-30 Hip circumference;Waist circumference; BRCA cis rs2070488 1.000 rs2268757 chr3:38505853 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.74 20.97 0.64 1.07e-74 Electrocardiographic conduction measures; BRCA trans rs4714291 0.925 rs847784 chr6:40053272 A/G cg02267698 chr19:7991119 CTXN1 0.4 7.9 0.3 1.23e-14 Strep throat; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg26314531 chr2:26401878 FAM59B 0.94 16.39 0.54 1.24e-50 Gut microbiome composition (summer); BRCA cis rs2882667 0.931 rs10077896 chr5:138356756 G/A cg04439458 chr5:138467593 SIL1 -0.33 -9.07 -0.34 1.44e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs514406 0.830 rs533935 chr1:53308807 T/C cg24675658 chr1:53192096 ZYG11B -0.51 -11.38 -0.41 1.89e-27 Monocyte count; BRCA cis rs478304 0.903 rs546202 chr11:65510024 C/T cg08755490 chr11:65554678 OVOL1 -0.5 -10.28 -0.38 4.93e-23 Acne (severe); BRCA cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg12311346 chr5:56204834 C5orf35 0.56 10.9 0.4 1.7e-25 Coronary artery disease; BRCA cis rs250677 0.652 rs250680 chr5:148436024 T/C cg18129178 chr5:148520854 ABLIM3 -0.6 -12.4 -0.44 8.39e-32 Breast cancer; BRCA cis rs13191362 1.000 rs36042757 chr6:163004744 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.74 11.76 0.42 4.72e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg15352829 chr14:105391018 PLD4 -0.38 -12.43 -0.44 6.67e-32 Rheumatoid arthritis; BRCA trans rs208520 0.874 rs208485 chr6:66925654 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.9 -16.3 -0.54 3.4e-50 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.53e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg08392591 chr16:89556376 ANKRD11 0.53 12.72 0.45 3.2e-33 Multiple myeloma (IgH translocation); BRCA cis rs60843830 1.000 rs62114544 chr2:269679 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.3 0.49 1.81e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6088590 0.561 rs6087605 chr20:33180624 G/T cg08999081 chr20:33150536 PIGU 0.5 14.13 0.49 1.18e-39 Coronary artery disease; BRCA cis rs6582630 0.519 rs1851121 chr12:38389467 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.47 0.38 9.11e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg25358565 chr5:93447407 FAM172A 1.2 18.59 0.59 5.7e-62 Diabetic retinopathy; BRCA cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg03354898 chr7:1950403 MAD1L1 -0.39 -8.35 -0.31 4.26e-16 Schizophrenia; BRCA cis rs1029738 0.659 rs1608553 chr7:22896231 G/C cg04907244 chr7:22894795 SNORD93 -0.39 -9.06 -0.34 1.56e-18 Fibrinogen levels; BRCA cis rs17095355 1.000 rs55683820 chr10:111665376 G/A cg00817464 chr10:111662876 XPNPEP1 -0.42 -8.88 -0.33 6.56e-18 Biliary atresia; BRCA cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg17971929 chr21:40555470 PSMG1 0.77 18.23 0.58 4.12e-60 Cognitive function; BRCA cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07930192 chr7:1003750 NA 0.48 10.71 0.39 1.01e-24 Longevity;Endometriosis; BRCA cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.58 12.3 0.44 2.42e-31 Age-related macular degeneration (geographic atrophy); BRCA cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg16339924 chr4:17578868 LAP3 0.62 15.42 0.52 7.56e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs911119 0.909 rs3761279 chr20:23620075 C/G cg16589663 chr20:23618590 CST3 0.47 8.81 0.33 1.2e-17 Chronic kidney disease; BRCA cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg03146154 chr1:46216737 IPP -0.5 -10.99 -0.4 7.55e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1005277 0.691 rs2474558 chr10:38486141 A/C cg25427524 chr10:38739819 LOC399744 0.67 15.12 0.51 2.17e-44 Extrinsic epigenetic age acceleration; BRCA cis rs698833 0.509 rs1372080 chr2:44540241 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 8.07 0.3 3.45e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg08132940 chr7:1081526 C7orf50 -0.58 -8.7 -0.33 2.79e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1451375 0.572 rs4948205 chr7:50557774 G/A cg18232548 chr7:50535776 DDC -0.42 -8.93 -0.33 4.4e-18 Malaria; BRCA cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.87e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg11752832 chr7:134001865 SLC35B4 0.5 11.27 0.41 5.56e-27 Mean platelet volume; BRCA cis rs1190552 0.894 rs4906203 chr14:102928991 C/T cg18135206 chr14:102964638 TECPR2 0.43 8.38 0.31 3.49e-16 Blood protein levels; BRCA cis rs7264396 0.635 rs6060692 chr20:34517925 A/T cg04508476 chr20:34239394 CPNE1;RBM12 0.7 14.7 0.5 2.25e-42 Total cholesterol levels; BRCA cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.52 8.1 0.31 2.74e-15 Lung function (FEV1/FVC); BRCA cis rs208520 0.770 rs1342960 chr6:66883514 T/C cg07460842 chr6:66804631 NA -0.95 -17.73 -0.57 1.73e-57 Exhaled nitric oxide output; BRCA cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg22535103 chr8:58192502 C8orf71 -0.63 -13.52 -0.47 8.57e-37 Developmental language disorder (linguistic errors); BRCA cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg26446133 chr18:72167187 CNDP2 -0.78 -14.43 -0.5 4.7e-41 Refractive error; BRCA cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg23029597 chr12:123009494 RSRC2 -0.63 -12.26 -0.44 3.49e-31 Body mass index; BRCA cis rs4481887 1.000 rs4916125 chr1:248466583 A/T cg13385794 chr1:248469461 NA 0.28 7.81 0.3 2.28e-14 Common traits (Other); BRCA cis rs35110281 0.633 rs762400 chr21:45113629 C/G cg04455712 chr21:45112962 RRP1B -0.44 -11.91 -0.43 1.13e-29 Mean corpuscular volume; BRCA cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg12310025 chr6:25882481 NA -0.55 -13.08 -0.46 8.48e-35 Blood metabolite levels; BRCA cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg18479299 chr3:125709523 NA -0.56 -8.78 -0.33 1.49e-17 Blood pressure (smoking interaction); BRCA cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.16 0.31 1.76e-15 Tonsillectomy; BRCA cis rs3862030 0.503 rs10786673 chr10:104280537 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.08 0.62 6.44e-70 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg04025307 chr7:1156635 C7orf50 0.44 9.77 0.36 4.02e-21 Longevity;Endometriosis; BRCA cis rs9517320 0.534 rs3825430 chr13:99129653 C/T cg20487152 chr13:99095054 FARP1 -0.33 -7.86 -0.3 1.68e-14 Longevity; BRCA cis rs2839186 0.559 rs2277826 chr21:47639492 C/G cg12379764 chr21:47803548 PCNT 0.39 7.89 0.3 1.29e-14 Testicular germ cell tumor; BRCA cis rs7100689 0.622 rs1417221 chr10:82100428 G/A cg01528321 chr10:82214614 TSPAN14 0.82 17.41 0.57 7.8e-56 Post bronchodilator FEV1; BRCA cis rs4363385 0.747 rs1015996 chr1:152976108 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg03477792 chr4:77819574 ANKRD56 0.64 15.18 0.51 1.19e-44 Emphysema distribution in smoking; BRCA cis rs9487051 0.836 rs9400270 chr6:109607488 G/A cg21918786 chr6:109611834 NA -0.49 -14.13 -0.49 1.19e-39 Reticulocyte fraction of red cells; BRCA cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg18876405 chr7:65276391 NA -0.62 -15.42 -0.52 7.35e-46 Aortic root size; BRCA trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs897984 0.513 rs17839568 chr16:31099783 T/C cg00531865 chr16:30841666 NA -0.38 -9.0 -0.34 2.5e-18 Dementia with Lewy bodies; BRCA cis rs2153535 0.547 rs9502720 chr6:8541362 C/A cg21535247 chr6:8435926 SLC35B3 0.39 8.65 0.32 4.14e-17 Motion sickness; BRCA cis rs4561483 0.801 rs33631 chr16:11995387 G/C cg08843971 chr16:11963173 GSPT1 -0.53 -12.05 -0.43 2.93e-30 Testicular germ cell tumor; BRCA cis rs2075371 1.000 rs1862051 chr7:133981021 G/A cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.43e-36 Mean platelet volume; BRCA trans rs9784649 1.000 rs9784649 chr5:25011524 G/A cg08600765 chr20:34638493 LOC647979 -0.56 -9.18 -0.34 5.87e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6743226 0.934 rs4303713 chr2:242257859 G/A cg10021735 chr2:242295487 FARP2 0.36 9.97 0.37 7.12e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs6840360 0.533 rs11099829 chr4:152727299 A/G cg22705602 chr4:152727874 NA 0.38 10.02 0.37 4.98e-22 Intelligence (multi-trait analysis); BRCA cis rs6580649 0.843 rs3803184 chr12:48398002 G/C cg24011408 chr12:48396354 COL2A1 0.52 8.85 0.33 8.55e-18 Lung cancer; BRCA cis rs4742903 0.509 rs10991107 chr9:106860969 T/C cg14250997 chr9:106856677 SMC2 0.27 8.07 0.3 3.41e-15 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7523050 0.643 rs36052234 chr1:109402943 C/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs4478858 0.684 rs4949373 chr1:31741577 G/A cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs9467773 1.000 rs9393729 chr6:26514166 C/T cg09904177 chr6:26538194 HMGN4 0.57 18.45 0.59 2.88e-61 Intelligence (multi-trait analysis); BRCA cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg23018236 chr17:30244563 NA -0.71 -11.1 -0.4 2.7e-26 Hip circumference adjusted for BMI; BRCA cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 14.17 0.49 8.02e-40 Colorectal cancer; BRCA cis rs2991971 1.000 rs606542 chr1:46013933 T/C cg15605315 chr1:45957053 TESK2 0.45 9.17 0.34 6.57e-19 High light scatter reticulocyte count; BRCA cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg22800045 chr5:56110881 MAP3K1 -0.59 -9.99 -0.37 6.42e-22 Initial pursuit acceleration; BRCA cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg26031613 chr14:104095156 KLC1 -0.49 -9.73 -0.36 5.77e-21 Schizophrenia; BRCA cis rs9467773 1.000 rs9467782 chr6:26542773 G/A cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs4722404 0.592 rs6461820 chr7:3118246 T/C cg19214707 chr7:3157722 NA -0.36 -7.92 -0.3 1.08e-14 Atopic dermatitis; BRCA cis rs11608355 0.515 rs61941631 chr12:109935475 C/T cg05360138 chr12:110035743 NA 0.72 13.3 0.47 8.56e-36 Neuroticism; BRCA cis rs9341808 0.644 rs59371711 chr6:80942027 G/T cg08355045 chr6:80787529 NA -0.32 -7.85 -0.3 1.72e-14 Sitting height ratio; BRCA cis rs2839186 0.619 rs2187118 chr21:47611310 C/T cg12379764 chr21:47803548 PCNT -0.41 -8.92 -0.33 4.84e-18 Testicular germ cell tumor; BRCA cis rs312274 0.698 rs11178967 chr12:41296632 A/G cg17827154 chr12:41323612 CNTN1 -0.45 -10.99 -0.4 7.37e-26 Metabolite levels (X-11787); BRCA cis rs12142240 0.660 rs112560929 chr1:46822297 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA trans rs61931739 0.500 rs11053273 chr12:34547255 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs4718428 0.705 rs68168107 chr7:66255238 G/A cg12165864 chr7:66369176 NA -0.44 -9.75 -0.36 4.78e-21 Corneal structure; BRCA cis rs2354432 0.607 rs7537483 chr1:146709877 C/G cg25205988 chr1:146714368 CHD1L 0.92 11.61 0.42 2.06e-28 Mitochondrial DNA levels; BRCA cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg10802521 chr3:52805072 NEK4 -0.31 -8.46 -0.32 1.89e-16 Electroencephalogram traits; BRCA cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg04546413 chr19:29218101 NA 0.47 9.69 0.36 7.99e-21 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg09184832 chr6:79620586 NA -0.47 -9.15 -0.34 7.36e-19 Intelligence (multi-trait analysis); BRCA cis rs17023223 0.537 rs6677107 chr1:119708765 C/T cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs7666738 0.791 rs13127542 chr4:98949159 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.87 0.56 4.31e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg03923535 chr7:1197113 ZFAND2A 0.54 10.92 0.4 1.43e-25 Longevity;Endometriosis; BRCA cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.41 -0.41 1.47e-27 Uric acid levels; BRCA cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg08885076 chr2:99613938 TSGA10 -0.58 -12.84 -0.45 9.62e-34 Chronic sinus infection; BRCA cis rs796364 0.806 rs74706215 chr2:200941367 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -10.84 -0.39 3e-25 Schizophrenia; BRCA cis rs921968 0.541 rs1863704 chr2:219562675 C/T cg02176678 chr2:219576539 TTLL4 -0.53 -13.28 -0.47 1.01e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs4595586 0.545 rs11615700 chr12:39365104 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.39e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7737355 0.947 rs739952 chr5:130796568 A/T cg06307176 chr5:131281290 NA -0.53 -10.58 -0.39 3.37e-24 Life satisfaction; BRCA cis rs11608355 0.545 rs2302709 chr12:109893697 A/G cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.21 0.34 4.81e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11098499 0.909 rs71614422 chr4:120359340 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.77 0.45 2.04e-33 Corneal astigmatism; BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg14004847 chr7:1930337 MAD1L1 0.46 8.79 0.33 1.41e-17 Bipolar disorder and schizophrenia; BRCA cis rs3796619 1.000 rs28620427 chr4:1086247 T/G cg27284194 chr4:1044797 NA 0.44 9.51 0.35 3.86e-20 Recombination rate (males); BRCA cis rs911119 0.657 rs6114214 chr20:23627924 A/T cg16589663 chr20:23618590 CST3 0.44 8.05 0.3 4.19e-15 Chronic kidney disease; BRCA cis rs11195062 0.521 rs4918485 chr10:111949323 A/T cg00817464 chr10:111662876 XPNPEP1 0.29 8.38 0.31 3.34e-16 Multiple myeloma; BRCA trans rs9291683 0.588 rs34501273 chr4:9996996 C/T cg26043149 chr18:55253948 FECH 0.38 8.63 0.32 4.87e-17 Bone mineral density; BRCA cis rs72781680 0.898 rs72782126 chr2:24039901 A/C cg08917208 chr2:24149416 ATAD2B 0.9 13.14 0.46 4.57e-35 Lymphocyte counts; BRCA cis rs67981189 0.572 rs2810077 chr14:71363814 A/G cg15816911 chr14:71606274 NA -0.38 -8.46 -0.32 1.82e-16 Schizophrenia; BRCA cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg03146154 chr1:46216737 IPP -0.5 -10.88 -0.4 2.06e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg26597838 chr10:835615 NA 1.02 17.69 0.57 2.58e-57 Eosinophil percentage of granulocytes; BRCA cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg18252515 chr7:66147081 NA -0.35 -7.82 -0.3 2.15e-14 Aortic root size; BRCA cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg12935359 chr14:103987150 CKB -0.57 -13.23 -0.46 1.67e-35 Body mass index; BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.96 0.43 6.56e-30 Tonsillectomy; BRCA cis rs6820391 0.590 rs4864802 chr4:54450331 T/C cg04173182 chr4:54446035 LNX1 0.48 10.66 0.39 1.6e-24 Cervical artery dissection; BRCA cis rs875971 0.660 rs801217 chr7:66010577 C/T cg18876405 chr7:65276391 NA -0.62 -15.48 -0.52 4.02e-46 Aortic root size; BRCA cis rs17401966 0.931 rs12137880 chr1:10388620 T/C cg19773385 chr1:10388646 KIF1B -0.4 -8.73 -0.33 2.28e-17 Hepatocellular carcinoma; BRCA cis rs4363385 0.747 rs1015996 chr1:152976108 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg22862634 chr11:62369728 EML3;MTA2 -0.5 -10.14 -0.37 1.7e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg00071950 chr4:10020882 SLC2A9 -0.47 -11.19 -0.4 1.16e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1008375 1.000 rs28552744 chr4:17620165 A/G cg16339924 chr4:17578868 LAP3 0.62 15.43 0.52 6.68e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4409675 0.576 rs10751725 chr1:28216191 A/C cg23691781 chr1:28212827 C1orf38 -0.32 -11.04 -0.4 4.63e-26 Corneal astigmatism; BRCA cis rs870825 0.616 rs745656 chr4:185637523 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.520 rs2309581 chr2:99784292 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.85 -25.92 -0.72 8.29e-102 Chronic sinus infection; BRCA cis rs11758351 1.000 rs11758351 chr6:26203910 T/G cg01420254 chr6:26195488 NA 0.53 8.33 0.31 4.78e-16 Gout;Renal underexcretion gout; BRCA cis rs3796619 0.961 rs62294748 chr4:1082999 G/A cg27284194 chr4:1044797 NA 0.44 9.44 0.35 6.57e-20 Recombination rate (males); BRCA cis rs1865760 1.000 rs7739966 chr6:25906040 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.27 0.41 5.3e-27 Height; BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg21724239 chr8:58056113 NA 0.55 8.83 0.33 9.92e-18 Developmental language disorder (linguistic errors); BRCA cis rs3858526 0.676 rs10838772 chr11:5895754 T/C cg13902645 chr11:5959945 NA -0.45 -8.84 -0.33 9.48e-18 DNA methylation (variation); BRCA cis rs858239 0.699 rs1881200 chr7:23201637 T/C cg23682824 chr7:23144976 KLHL7 -0.33 -8.57 -0.32 7.56e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs1215050 0.791 rs783950 chr4:98878395 C/T cg05340658 chr4:99064831 C4orf37 -0.45 -10.25 -0.38 6.17e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.34 -0.44 1.52e-31 Tonsillectomy; BRCA cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg11764359 chr7:65958608 NA -0.77 -17.73 -0.57 1.71e-57 Aortic root size; BRCA trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg03929089 chr4:120376271 NA 0.51 7.84 0.3 1.88e-14 Intraocular pressure; BRCA cis rs34779708 0.931 rs79749947 chr10:35277081 A/T cg03585969 chr10:35415529 CREM 0.56 11.45 0.41 9.44e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9487051 0.768 rs351742 chr6:109527325 C/T cg01475377 chr6:109611718 NA 0.39 9.95 0.37 9.11e-22 Reticulocyte fraction of red cells; BRCA cis rs7903847 0.642 rs11189196 chr10:99155079 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.77 -0.33 1.63e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6543140 0.964 rs4851592 chr2:103087641 C/T cg04239558 chr2:103089729 SLC9A4 0.35 9.95 0.37 8.61e-22 Blood protein levels; BRCA cis rs6540559 0.611 rs17015226 chr1:209970096 C/G cg22029157 chr1:209979665 IRF6 0.51 10.53 0.38 5.01e-24 Cleft lip with or without cleft palate; BRCA cis rs17818399 0.633 rs2242033 chr2:46842410 A/G cg02822958 chr2:46747628 ATP6V1E2 0.47 9.59 0.35 1.94e-20 Height; BRCA cis rs1949733 0.675 rs2688235 chr4:8450546 T/C cg13073564 chr4:8508604 NA -0.39 -10.56 -0.39 3.78e-24 Response to antineoplastic agents; BRCA cis rs7246657 0.941 rs7259618 chr19:37750719 G/A cg23950597 chr19:37808831 NA -0.65 -11.0 -0.4 6.51e-26 Coronary artery calcification; BRCA cis rs66887589 0.967 rs1155577 chr4:120449810 C/T cg09307838 chr4:120376055 NA -0.46 -9.53 -0.35 3.23e-20 Diastolic blood pressure; BRCA trans rs7395662 1.000 rs4929903 chr11:48913332 T/G cg00717180 chr2:96193071 NA -0.31 -8.66 -0.32 3.73e-17 HDL cholesterol; BRCA cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs3760982 0.585 rs61013802 chr19:44292142 A/T cg12072164 chr19:44306565 LYPD5 0.36 8.7 0.33 2.81e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs10751667 0.600 rs6597948 chr11:1005308 C/T ch.11.42038R chr11:967971 AP2A2 0.47 14.35 0.49 1.07e-40 Alzheimer's disease (late onset); BRCA cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9858542 0.953 rs12330269 chr3:49513910 G/A cg03060546 chr3:49711283 APEH -0.53 -10.58 -0.39 3.33e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.81 -0.58 6.72e-58 Chronic sinus infection; BRCA cis rs28374715 0.532 rs28463309 chr15:41666716 A/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -25.61 -0.71 4.29e-100 Ulcerative colitis; BRCA cis rs490234 0.812 rs13286111 chr9:128429951 A/T cg14078157 chr9:128172775 NA -0.44 -9.72 -0.36 6.55e-21 Mean arterial pressure; BRCA cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg08917208 chr2:24149416 ATAD2B 0.93 13.64 0.47 2.22e-37 Lymphocyte counts; BRCA trans rs9650657 0.547 rs11250099 chr8:10818657 C/T cg15556689 chr8:8085844 FLJ10661 0.39 10.42 0.38 1.36e-23 Neuroticism; BRCA cis rs1209950 1.000 rs1209950 chr21:40173528 A/G cg01359822 chr21:40176597 ETS2 -0.35 -8.85 -0.33 8.42e-18 Non-small cell lung cancer (survival); BRCA cis rs11874712 1.000 rs7244921 chr18:43667528 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs12760731 0.565 rs10913520 chr1:178200760 A/T cg00404053 chr1:178313656 RASAL2 0.64 7.9 0.3 1.2e-14 Obesity-related traits; BRCA cis rs4566357 0.615 rs12621808 chr2:227909522 A/C cg05526886 chr2:227700861 RHBDD1 -0.39 -8.07 -0.3 3.55e-15 Coronary artery disease; BRCA trans rs10506458 0.834 rs58821476 chr12:63389425 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.2 -18.94 -0.6 8.26e-64 Hemostatic factors and hematological phenotypes; BRCA cis rs10496034 1.000 rs4671995 chr2:55150883 C/T cg16098955 chr2:55172992 EML6 0.52 9.17 0.34 6.4e-19 Refractive astigmatism; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg18402987 chr7:1209562 NA 0.81 12.07 0.43 2.32e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg03213289 chr20:61660250 NA 0.63 15.78 0.53 1.24e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs6964587 0.934 rs12531561 chr7:91707780 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.04 0.3 4.34e-15 Breast cancer; BRCA cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg08917208 chr2:24149416 ATAD2B 1.12 15.73 0.53 2.41e-47 Lymphocyte counts; BRCA cis rs875971 0.545 rs13311962 chr7:66068129 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.54 -10.17 -0.37 1.24e-22 Aortic root size; BRCA cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg01483505 chr11:975446 AP2A2 0.33 8.87 0.33 7.13e-18 Alzheimer's disease (late onset); BRCA cis rs523522 0.962 rs10849758 chr12:120971149 C/T cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.17e-27 High light scatter reticulocyte count; BRCA cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg21573476 chr21:45109991 RRP1B -0.36 -9.51 -0.35 3.65e-20 Mean corpuscular volume; BRCA cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg01939980 chr4:1354348 KIAA1530 0.38 8.81 0.33 1.19e-17 Obesity-related traits; BRCA cis rs9815354 0.812 rs73073233 chr3:42010550 A/G cg03022575 chr3:42003672 ULK4 0.73 10.09 0.37 2.48e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs1499972 0.941 rs62264783 chr3:117658033 G/A cg07612923 chr3:117604196 NA 0.6 8.08 0.3 3.15e-15 Schizophrenia; BRCA cis rs2070488 0.930 rs928813 chr3:38528537 G/T cg24069376 chr3:38537580 EXOG 0.43 12.22 0.44 5e-31 Electrocardiographic conduction measures; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.74 16.22 0.54 8.69e-50 Lymphocyte counts; BRCA cis rs2742234 1.000 rs2742234 chr10:43612609 A/G cg02780029 chr10:43622663 RET 0.39 9.9 0.36 1.34e-21 Hirschsprung disease; BRCA cis rs2235642 0.507 rs2235645 chr16:1597924 C/T cg03034668 chr16:1723424 CRAMP1L -0.5 -10.62 -0.39 2.28e-24 Coronary artery disease; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg09877947 chr5:131593287 PDLIM4 0.46 11.17 0.4 1.37e-26 Acylcarnitine levels; BRCA cis rs7903847 0.620 rs10882903 chr10:99115584 A/T cg08345082 chr10:99160200 RRP12 -0.28 -8.03 -0.3 4.55e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs9486719 0.843 rs976357 chr6:96849679 C/T cg06623918 chr6:96969491 KIAA0776 0.75 12.34 0.44 1.59e-31 Migraine;Coronary artery disease; BRCA trans rs2262909 0.925 rs73019838 chr19:22247732 T/A cg17074339 chr11:11642133 GALNTL4 0.42 8.12 0.31 2.45e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs208520 0.742 rs208454 chr6:66907783 T/C cg07460842 chr6:66804631 NA -0.89 -15.26 -0.52 4.77e-45 Exhaled nitric oxide output; BRCA cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg05535760 chr7:792225 HEATR2 0.77 13.65 0.48 2.15e-37 Cerebrospinal P-tau181p levels; BRCA cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg08917208 chr2:24149416 ATAD2B 1.08 15.26 0.52 4.69e-45 Lymphocyte counts; BRCA cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg08280861 chr8:58055591 NA -0.53 -8.58 -0.32 7.25e-17 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs17361812 chr1:46814008 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg12011299 chr4:100065546 ADH4 0.41 9.44 0.35 6.93e-20 Alcohol dependence; BRCA cis rs4891159 0.790 rs72973773 chr18:74115176 T/C cg24786174 chr18:74118243 ZNF516 -0.76 -18.62 -0.59 4e-62 Longevity; BRCA cis rs858239 0.600 rs10241208 chr7:23144914 G/C cg23682824 chr7:23144976 KLHL7 0.42 11.22 0.41 8.5e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.75 0.45 2.44e-33 Bipolar disorder; BRCA trans rs10838798 0.523 rs4752917 chr11:48241639 A/G cg15704280 chr7:45808275 SEPT13 -0.4 -8.0 -0.3 5.89e-15 Height; BRCA cis rs4642101 0.793 rs6763619 chr3:12822147 T/G cg24848339 chr3:12840334 CAND2 0.43 11.36 0.41 2.39e-27 QRS complex (12-leadsum); BRCA cis rs6088590 1.000 rs6119535 chr20:33442138 A/C cg24642439 chr20:33292090 TP53INP2 0.62 13.98 0.48 5.92e-39 Coronary artery disease; BRCA cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg21138405 chr5:131827807 IRF1 0.4 13.23 0.46 1.69e-35 Asthma (sex interaction); BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA trans rs3780486 0.813 rs3780488 chr9:33133812 T/C cg04842962 chr6:43655489 MRPS18A 1.12 38.45 0.84 2.14e-168 IgG glycosylation; BRCA cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg04025307 chr7:1156635 C7orf50 0.48 11.02 0.4 5.66e-26 Bronchopulmonary dysplasia; BRCA cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg06064525 chr11:970664 AP2A2 -0.48 -16.27 -0.54 4.72e-50 Alzheimer's disease (late onset); BRCA cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.1 0.4 2.68e-26 Bipolar disorder; BRCA cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.32 10.11 0.37 2.22e-22 Bipolar disorder; BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg03188948 chr7:1209495 NA 0.45 8.31 0.31 5.57e-16 Longevity;Endometriosis; BRCA cis rs1351164 1.000 rs1351164 chr2:218271898 C/T cg15335768 chr2:218268053 DIRC3 0.34 8.52 0.32 1.15e-16 Height; BRCA cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg08885076 chr2:99613938 TSGA10 -0.56 -12.81 -0.45 1.27e-33 Chronic sinus infection; BRCA cis rs507080 0.885 rs533144 chr11:118559247 C/A cg08498647 chr11:118550644 TREH -0.38 -8.29 -0.31 6.82e-16 Serum metabolite levels; BRCA cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.29 -0.34 2.39e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg19346786 chr7:2764209 NA -0.36 -11.04 -0.4 4.54e-26 Height; BRCA cis rs936229 1.000 rs936229 chr15:75132319 A/G cg10253484 chr15:75165896 SCAMP2 -0.53 -9.96 -0.37 7.98e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs113835537 0.597 rs2305534 chr11:66313203 T/C cg24851651 chr11:66362959 CCS 0.49 9.06 0.34 1.6e-18 Airway imaging phenotypes; BRCA cis rs3925075 0.531 rs4261553 chr16:31349164 T/C cg02846316 chr16:31340340 ITGAM 0.42 8.65 0.32 4.12e-17 IgA nephropathy; BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00908189 chr16:619842 PIGQ 0.68 16.93 0.56 2.08e-53 Height; BRCA cis rs877282 0.898 rs2004478 chr10:770709 C/A cg17470449 chr10:769945 NA 0.49 9.09 0.34 1.27e-18 Uric acid levels; BRCA cis rs6977660 0.714 rs9969381 chr7:19827454 C/T cg05791153 chr7:19748676 TWISTNB 0.6 11.17 0.4 1.37e-26 Thyroid stimulating hormone; BRCA cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.34 0.38 2.72e-23 Bipolar disorder; BRCA cis rs694739 0.536 rs671976 chr11:64046029 G/A cg23796481 chr11:64053134 BAD;GPR137 0.34 7.84 0.3 1.95e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs701145 0.585 rs1727920 chr3:153788588 C/T cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg24558204 chr6:135376177 HBS1L -0.42 -11.23 -0.41 7.67e-27 Red blood cell count; BRCA cis rs2370759 1.000 rs79806114 chr10:32618022 T/C cg01819863 chr10:32635814 EPC1 1.22 21.42 0.65 4.1e-77 Sexual dysfunction (female); BRCA cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11890956 chr21:40555474 PSMG1 0.59 13.12 0.46 5.19e-35 Menarche (age at onset); BRCA cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg02297831 chr4:17616191 MED28 0.36 8.44 0.32 2.09e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10174077 0.874 rs4664490 chr2:152471923 C/G cg19508488 chr2:152266495 RIF1 -0.45 -9.38 -0.35 1.14e-19 Squamous cell lung carcinoma; BRCA cis rs6582630 0.555 rs10880624 chr12:38526316 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.81 0.58 6.4e-58 Drug-induced liver injury (flucloxacillin); BRCA cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.43 0.5 4.82e-41 Personality dimensions; BRCA cis rs758324 0.947 rs10052255 chr5:131173106 C/T cg06307176 chr5:131281290 NA 0.53 10.14 0.37 1.68e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs3762637 0.943 rs28403550 chr3:122251838 C/A cg24169773 chr3:122142474 KPNA1 -0.43 -7.98 -0.3 6.65e-15 LDL cholesterol levels; BRCA cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg13944838 chr5:179740914 GFPT2 -0.72 -15.52 -0.52 2.45e-46 Height; BRCA cis rs2204008 0.805 rs12146846 chr12:37985847 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.09 0.56 3.13e-54 Bladder cancer; BRCA cis rs2880765 0.835 rs6497202 chr15:86021375 T/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.43 -0.32 2.38e-16 Coronary artery disease; BRCA cis rs12310956 0.532 rs11494810 chr12:33952881 C/A cg06521331 chr12:34319734 NA -0.55 -10.67 -0.39 1.47e-24 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs78527234 chr2:200913453 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg11764359 chr7:65958608 NA 0.66 12.1 0.43 1.78e-30 Aortic root size; BRCA cis rs4812048 0.649 rs3761257 chr20:57618787 C/T cg14073986 chr20:57617431 SLMO2 0.81 13.38 0.47 3.75e-36 Mean platelet volume; BRCA cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg27624424 chr6:160112604 SOD2 0.4 8.22 0.31 1.13e-15 Age-related macular degeneration (geographic atrophy); BRCA cis rs4076764 0.958 rs12022261 chr1:163398422 A/G cg06092702 chr1:163392909 NA -0.36 -9.6 -0.35 1.85e-20 Motion sickness; BRCA cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg22800045 chr5:56110881 MAP3K1 0.64 11.93 0.43 9.58e-30 Initial pursuit acceleration; BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg27170947 chr2:26402098 FAM59B -0.7 -11.68 -0.42 1.09e-28 Gut microbiome composition (summer); BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg05650719 chr12:132293520 NA -0.4 -8.48 -0.32 1.5e-16 Migraine; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.62 -12.85 -0.45 8.62e-34 Lymphocyte counts; BRCA cis rs7666738 0.830 rs7691433 chr4:98968118 A/T cg17366294 chr4:99064904 C4orf37 0.42 10.0 0.37 5.54e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg25174290 chr11:3078921 CARS -0.3 -7.84 -0.3 1.88e-14 Calcium levels; BRCA cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.33 0.38 2.97e-23 Aortic root size; BRCA trans rs8002861 0.967 rs7984393 chr13:44484361 T/C cg17145862 chr1:211918768 LPGAT1 0.69 18.15 0.58 1.04e-59 Leprosy; BRCA cis rs6545883 0.929 rs2593635 chr2:61634706 A/C cg15711740 chr2:61764176 XPO1 0.55 13.52 0.47 8.26e-37 Tuberculosis; BRCA cis rs11971779 0.590 rs6944104 chr7:139051120 T/A cg07862535 chr7:139043722 LUC7L2 0.38 10.28 0.38 4.63e-23 Diisocyanate-induced asthma; BRCA cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg11301795 chr4:187892539 NA -0.26 -8.69 -0.33 3.01e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs11190604 1.000 rs11190613 chr10:102313997 C/T cg07080220 chr10:102295463 HIF1AN -0.6 -14.52 -0.5 1.72e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.31 0.41 3.74e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs7523273 0.606 rs2724387 chr1:207932617 T/G cg22525895 chr1:207977042 MIR29B2 0.47 12.05 0.43 2.91e-30 Schizophrenia; BRCA cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.54 8.24 0.31 1.01e-15 Gut microbiome composition (summer); BRCA cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.59 -13.75 -0.48 6.88e-38 Blood protein levels;Circulating chemerin levels; BRCA cis rs3820928 0.874 rs4234064 chr2:227857497 G/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.3 -0.31 6.41e-16 Pulmonary function; BRCA cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.2 -0.54 1.01e-49 Alzheimer's disease (late onset); BRCA cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg03146154 chr1:46216737 IPP 0.45 9.94 0.37 9.83e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg18876405 chr7:65276391 NA -0.51 -11.75 -0.42 5.48e-29 Aortic root size; BRCA cis rs17401966 0.540 rs4846216 chr1:10447792 A/T cg03954927 chr1:10346856 KIF1B -0.34 -10.17 -0.37 1.27e-22 Hepatocellular carcinoma; BRCA cis rs911186 0.891 rs6914824 chr6:27139048 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.34 -8.74 -0.33 2.06e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs4662945 0.525 rs4662951 chr2:130256272 C/T cg05903289 chr2:130345205 NA -0.31 -7.81 -0.3 2.44e-14 Response to cytidine analogues (gemcitabine); BRCA cis rs897984 0.609 rs732173 chr16:31050023 C/A cg02466173 chr16:30829666 NA -0.45 -9.98 -0.37 6.58e-22 Dementia with Lewy bodies; BRCA cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg12386194 chr3:101231763 SENP7 0.46 9.88 0.36 1.64e-21 Colorectal cancer; BRCA cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg22834771 chr12:69754056 YEATS4 -0.43 -10.63 -0.39 2.04e-24 Cerebrospinal fluid biomarker levels; BRCA trans rs8073060 0.505 rs225270 chr17:33968871 A/T cg19694781 chr19:47549865 TMEM160 -1.06 -21.58 -0.65 5.04e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs3858526 0.755 rs10769368 chr11:5962084 C/T cg13902645 chr11:5959945 NA 0.46 10.07 0.37 3.2e-22 DNA methylation (variation); BRCA cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg02297831 chr4:17616191 MED28 0.37 8.58 0.32 6.93e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs59918340 0.728 rs35257077 chr8:142235049 C/T cg23750338 chr8:142222470 SLC45A4 -0.5 -11.49 -0.41 6.35e-28 Immature fraction of reticulocytes; BRCA cis rs1580019 0.587 rs1597555 chr7:32546118 T/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 29.96 0.76 7.16e-124 Cognitive ability; BRCA cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg17173187 chr15:85201210 NMB 0.44 9.31 0.35 2.1e-19 Schizophrenia; BRCA cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg22800045 chr5:56110881 MAP3K1 0.65 12.18 0.43 7.48e-31 Initial pursuit acceleration; BRCA cis rs6723226 0.739 rs2069213 chr2:32743084 C/T cg02381751 chr2:32503542 YIPF4 0.6 12.83 0.45 1.06e-33 Intelligence (multi-trait analysis); BRCA cis rs9341808 0.690 rs6930534 chr6:80896050 C/T cg08355045 chr6:80787529 NA 0.39 9.88 0.36 1.64e-21 Sitting height ratio; BRCA cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.39e-16 Colorectal cancer; BRCA cis rs6547741 0.788 rs7595739 chr2:27874563 G/T cg27432699 chr2:27873401 GPN1 -0.5 -10.51 -0.38 6.02e-24 Oral cavity cancer; BRCA cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg12365402 chr11:9010492 NRIP3 -0.42 -9.76 -0.36 4.46e-21 Hemoglobin concentration; BRCA cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg03452623 chr4:187889614 NA -0.35 -11.66 -0.42 1.32e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs2658782 0.724 rs2605629 chr11:93264037 C/G cg15737290 chr11:93063684 CCDC67 -0.49 -9.39 -0.35 1.05e-19 Pulmonary function decline; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg25036284 chr2:26402008 FAM59B 0.96 16.04 0.54 6.76e-49 Gut microbiome composition (summer); BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 17.77 0.57 1.1e-57 Platelet count; BRCA trans rs561341 1.000 rs530715 chr17:30320544 T/G cg27661571 chr11:113659931 NA -0.5 -8.56 -0.32 8.43e-17 Hip circumference adjusted for BMI; BRCA cis rs1997103 1.000 rs4947500 chr7:55407270 C/A cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg11764359 chr7:65958608 NA 0.65 11.2 0.41 1.03e-26 Aortic root size; BRCA cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg16325326 chr1:53192061 ZYG11B -0.65 -16.24 -0.54 6.87e-50 Monocyte count; BRCA cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg11752832 chr7:134001865 SLC35B4 0.5 12.93 0.46 4.01e-34 Mean platelet volume; BRCA trans rs1005277 0.579 rs2504143 chr10:38383706 C/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.89 -0.48 1.62e-38 Extrinsic epigenetic age acceleration; BRCA cis rs11098499 0.863 rs11736416 chr4:120431661 C/T cg09307838 chr4:120376055 NA 0.7 14.19 0.49 5.99e-40 Corneal astigmatism; BRCA cis rs9325144 0.647 rs12830095 chr12:38864199 C/T cg26384229 chr12:38710491 ALG10B -0.5 -12.1 -0.43 1.65e-30 Morning vs. evening chronotype; BRCA cis rs11605275 1.000 rs11605704 chr11:20032096 A/G cg14835545 chr11:20032148 NAV2 0.62 10.14 0.37 1.62e-22 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.84 15.26 0.52 4.71e-45 Platelet count; BRCA cis rs7666738 0.830 rs3846445 chr4:99032939 T/A cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.522 rs891920 chr5:148369418 G/T cg18129178 chr5:148520854 ABLIM3 -0.55 -10.42 -0.38 1.4e-23 Breast cancer; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg02675527 chr2:114030824 PAX8;LOC440839 -0.42 -10.09 -0.37 2.64e-22 Lymphocyte counts; BRCA cis rs11758351 0.660 rs1997768 chr6:26217728 C/T cg01420254 chr6:26195488 NA -0.52 -8.31 -0.31 5.62e-16 Gout;Renal underexcretion gout; BRCA cis rs2806561 0.704 rs636940 chr1:23522967 A/T cg12483005 chr1:23474871 LUZP1 0.48 10.46 0.38 9.57e-24 Height; BRCA cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg19077165 chr18:44547161 KATNAL2 -0.59 -13.26 -0.46 1.25e-35 Personality dimensions; BRCA cis rs9287719 0.967 rs6748036 chr2:10717489 C/T cg00105475 chr2:10696890 NA 0.44 10.23 0.37 7.84e-23 Prostate cancer; BRCA cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg06697600 chr4:7070879 GRPEL1 -0.56 -10.26 -0.38 5.54e-23 Monocyte percentage of white cells; BRCA cis rs12291225 0.679 rs11023170 chr11:14294909 A/G cg19336497 chr11:14380999 RRAS2 -0.48 -12.07 -0.43 2.25e-30 Sense of smell; BRCA cis rs4077515 0.935 rs3812565 chr9:139272502 T/C cg14019695 chr9:139328340 INPP5E 0.35 8.91 0.33 5.29e-18 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7635838 0.596 rs4684765 chr3:11261085 G/C cg00170343 chr3:11313890 ATG7 0.41 8.23 0.31 1.08e-15 HDL cholesterol; BRCA cis rs4803468 1.000 rs1473248 chr19:41923314 C/T cg09537434 chr19:41945824 ATP5SL 0.99 23.76 0.68 6.49e-90 Height; BRCA cis rs10771431 0.597 rs10771413 chr12:9354413 C/T cg08997352 chr12:9597637 DDX12 -0.54 -10.21 -0.37 8.78e-23 Breast size; BRCA trans rs1005277 0.557 rs176887 chr10:38406094 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.51 -0.32 1.2e-16 Extrinsic epigenetic age acceleration; BRCA cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.04 -0.54 6.86e-49 Alzheimer's disease (late onset); BRCA cis rs12200782 0.505 rs9295696 chr6:26550288 C/T cg09904177 chr6:26538194 HMGN4 0.39 8.76 0.33 1.8e-17 Small cell lung carcinoma; BRCA trans rs11039798 1.000 rs8188963 chr11:48685693 C/A cg15704280 chr7:45808275 SEPT13 0.6 8.83 0.33 1.02e-17 Axial length; BRCA cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg03146154 chr1:46216737 IPP 0.48 10.66 0.39 1.58e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs6089829 1.000 rs6089828 chr20:61668998 C/T cg17470723 chr8:74884337 TCEB1 0.4 8.67 0.32 3.58e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs34779708 0.897 rs16935880 chr10:35415468 C/G cg03585969 chr10:35415529 CREM 0.55 11.37 0.41 2.17e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24549020 chr5:56110836 MAP3K1 0.67 13.19 0.46 2.64e-35 Initial pursuit acceleration; BRCA cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 10.2 0.37 1.02e-22 Bipolar disorder; BRCA cis rs6430585 0.527 rs76622824 chr2:136411879 A/G cg07169764 chr2:136633963 MCM6 1.0 19.69 0.61 7.75e-68 Corneal structure; BRCA cis rs847649 0.731 rs7785272 chr7:102671023 A/G cg18108683 chr7:102477205 FBXL13 -0.36 -8.05 -0.3 4.03e-15 Morning vs. evening chronotype; BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg06468780 chr21:31798236 KRTAP13-3 0.34 8.47 0.32 1.71e-16 HDL cholesterol; BRCA cis rs514406 0.708 rs480299 chr1:53320274 G/T cg01802117 chr1:53393560 SCP2 -0.4 -8.82 -0.33 1.11e-17 Monocyte count; BRCA cis rs477692 0.597 rs574831 chr10:131379190 C/T cg05714579 chr10:131428358 MGMT -0.49 -11.11 -0.4 2.54e-26 Response to temozolomide; BRCA cis rs943466 1.000 rs6933607 chr6:33743997 G/A cg25922239 chr6:33757077 LEMD2 -0.39 -7.84 -0.3 1.85e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs1865760 1.000 rs9358895 chr6:25924655 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 11.35 0.41 2.61e-27 Height; BRCA cis rs6964587 0.904 rs6465339 chr7:91570790 T/A cg17063962 chr7:91808500 NA -0.57 -13.43 -0.47 2.05e-36 Breast cancer; BRCA cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg15017067 chr4:17643749 FAM184B 0.26 7.85 0.3 1.79e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.79e-68 Blood protein levels; BRCA cis rs11190604 0.806 rs76835764 chr10:102193612 C/T cg07080220 chr10:102295463 HIF1AN 0.44 9.8 0.36 3.19e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg15605315 chr1:45957053 TESK2 0.46 9.44 0.35 6.73e-20 High light scatter reticulocyte count; BRCA cis rs7590368 0.961 rs13431852 chr2:10960410 T/C cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.02e-15 Educational attainment (years of education); BRCA cis rs11168351 0.591 rs4258439 chr12:48468652 A/G cg24011408 chr12:48396354 COL2A1 -0.44 -9.85 -0.36 2.05e-21 Bipolar disorder and schizophrenia; BRCA cis rs7927771 0.524 rs7101597 chr11:47797917 A/T cg20307385 chr11:47447363 PSMC3 0.42 9.54 0.35 3.01e-20 Subjective well-being; BRCA cis rs1865721 0.771 rs72975986 chr18:73127649 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.29 -0.38 4.6e-23 Intelligence; BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg00814883 chr7:100076585 TSC22D4 -0.47 -10.54 -0.38 4.62e-24 Platelet count; BRCA cis rs9858542 0.953 rs6446264 chr3:49417243 C/A cg03060546 chr3:49711283 APEH -0.5 -10.14 -0.37 1.74e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs11098499 0.820 rs13122709 chr4:120555356 T/A cg25214090 chr10:38739885 LOC399744 0.53 11.74 0.42 5.69e-29 Corneal astigmatism; BRCA cis rs9473147 0.516 rs9367284 chr6:47516369 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.61 0.36 1.61e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs12579753 1.000 rs7300900 chr12:82166821 G/T cg07988820 chr12:82153109 PPFIA2 -0.65 -10.16 -0.37 1.43e-22 Resting heart rate; BRCA cis rs3784262 0.669 rs3742959 chr15:58249113 A/G cg12031962 chr15:58353849 ALDH1A2 -0.35 -9.64 -0.36 1.29e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs72781680 0.848 rs6748727 chr2:24041058 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.01 0.34 2.37e-18 Lymphocyte counts; BRCA cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.68 0.32 3.33e-17 Motion sickness; BRCA trans rs2204008 0.805 rs2874289 chr12:38258420 G/A cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.11e-20 Bladder cancer; BRCA cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg06784218 chr1:46089804 CCDC17 0.5 12.05 0.43 2.88e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs4942242 1.000 rs7331003 chr13:44230253 C/T cg19169023 chr15:41853346 TYRO3 -0.49 -11.45 -0.41 9.61e-28 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7520050 0.933 rs12045165 chr1:46256022 C/A cg24296786 chr1:45957014 TESK2 0.45 10.17 0.37 1.32e-22 Red blood cell count;Reticulocyte count; BRCA cis rs10927875 1.000 rs3979179 chr1:16306846 A/G cg21385522 chr1:16154831 NA 0.6 11.32 0.41 3.25e-27 Dilated cardiomyopathy; BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg13567636 chr1:160991154 F11R -0.48 -9.36 -0.35 1.35e-19 Granulocyte percentage of myeloid white cells; BRCA trans rs7819412 0.525 rs10086521 chr8:10783769 A/G cg15556689 chr8:8085844 FLJ10661 -0.34 -8.44 -0.32 2.05e-16 Triglycerides; BRCA cis rs6964587 1.000 rs13224513 chr7:91601465 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.88e-15 Breast cancer; BRCA trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg08975724 chr8:8085496 FLJ10661 0.38 8.13 0.31 2.18e-15 Retinal vascular caliber; BRCA cis rs7772486 0.875 rs932522 chr6:146374026 A/G cg23711669 chr6:146136114 FBXO30 -0.68 -15.78 -0.53 1.33e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg27279351 chr12:120934652 DYNLL1 0.51 12.39 0.44 9.44e-32 High light scatter reticulocyte count; BRCA cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg16405210 chr4:1374714 KIAA1530 -0.5 -11.83 -0.42 2.44e-29 Longevity; BRCA cis rs6430585 0.583 rs3769001 chr2:136626078 A/G cg07169764 chr2:136633963 MCM6 1.28 28.22 0.74 2.21e-114 Corneal structure; BRCA cis rs17270561 0.639 rs9356989 chr6:25781950 A/G cg17691542 chr6:26056736 HIST1H1C 0.56 10.88 0.4 2.11e-25 Iron status biomarkers; BRCA cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg10253484 chr15:75165896 SCAMP2 -0.6 -11.56 -0.42 3.3e-28 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs2011503 1.000 rs56280531 chr19:19585788 A/C cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs9309711 0.772 rs9752251 chr2:3489869 C/T cg16153549 chr2:3496821 NA -0.44 -10.12 -0.37 2.01e-22 Neurofibrillary tangles; BRCA cis rs9467711 0.591 rs13195692 chr6:26044373 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.29 0.35 2.32e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs9287719 0.935 rs728283 chr2:10750090 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.11 0.37 2.23e-22 Aortic root size; BRCA cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg27535305 chr1:53392650 SCP2 -0.35 -8.68 -0.32 3.16e-17 Monocyte count; BRCA trans rs11098499 0.775 rs10029303 chr4:120286755 T/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs798766 1.000 rs7682402 chr4:1743343 G/A cg05874882 chr4:1763078 NA -0.48 -8.62 -0.32 5.33e-17 Bladder cancer;Urinary bladder cancer; BRCA cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg06784218 chr1:46089804 CCDC17 0.49 11.75 0.42 5.47e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs55882075 0.723 rs56227602 chr5:179179472 A/G cg14593053 chr5:179126677 CANX 0.48 13.11 0.46 6.03e-35 Monocyte percentage of white cells; BRCA cis rs11690935 0.550 rs7584187 chr2:172866105 A/G cg13550731 chr2:172543902 DYNC1I2 -0.48 -11.85 -0.42 1.94e-29 Schizophrenia; BRCA trans rs11039798 0.588 rs666165 chr11:48457439 C/T cg15704280 chr7:45808275 SEPT13 -0.46 -8.0 -0.3 5.7e-15 Axial length; BRCA cis rs6032067 0.673 rs4522674 chr20:43893276 T/C cg20256260 chr20:43936981 MATN4;RBPJL 0.34 8.17 0.31 1.67e-15 Blood protein levels; BRCA cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 4.09e-29 Bipolar disorder; BRCA cis rs3741404 0.825 rs11603384 chr11:63949095 G/A cg18225595 chr11:63971243 STIP1 0.58 13.84 0.48 2.61e-38 Platelet count; BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.1 0.34 1.16e-18 Tonsillectomy; BRCA cis rs10504073 0.669 rs818560 chr8:50035417 C/T cg00325661 chr8:49890786 NA 0.38 10.92 0.4 1.42e-25 Blood metabolite ratios; BRCA cis rs28374715 0.681 rs7162231 chr15:41591859 G/A cg18705301 chr15:41695430 NDUFAF1 -1.03 -24.37 -0.69 2.96e-93 Ulcerative colitis; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.62 -13.34 -0.47 5.33e-36 Lymphocyte counts; BRCA cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg14844989 chr11:31128820 NA -0.45 -9.6 -0.36 1.76e-20 Red blood cell count; BRCA cis rs3768617 0.811 rs12022720 chr1:183017223 A/G ch.1.3577855R chr1:183094577 LAMC1 0.43 9.41 0.35 8.64e-20 Fuchs's corneal dystrophy; BRCA cis rs490234 0.702 rs1339499 chr9:128406453 T/C cg14078157 chr9:128172775 NA -0.48 -10.82 -0.39 3.52e-25 Mean arterial pressure; BRCA cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg18876405 chr7:65276391 NA -0.71 -18.88 -0.6 1.67e-63 Calcium levels; BRCA cis rs1371614 0.589 rs527267 chr2:27119655 G/C cg12368169 chr2:27073192 DPYSL5 -0.31 -9.14 -0.34 8.23e-19 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg08847533 chr14:75593920 NEK9 0.83 20.57 0.63 1.56e-72 Height; BRCA cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg10523679 chr1:76189770 ACADM -0.62 -11.83 -0.42 2.38e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2243480 1.000 rs160652 chr7:65538431 A/G cg18252515 chr7:66147081 NA -1.05 -14.43 -0.5 4.68e-41 Diabetic kidney disease; BRCA cis rs908922 0.676 rs4112786 chr1:152532872 T/A cg20991723 chr1:152506922 NA 0.36 7.96 0.3 8.02e-15 Hair morphology; BRCA trans rs11722228 0.522 rs12503195 chr4:10082772 T/C cg26043149 chr18:55253948 FECH 0.68 15.7 0.53 3.08e-47 Gout;Urate levels;Serum uric acid levels; BRCA cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.89e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs290268 0.874 rs290994 chr9:93559515 T/A cg02608019 chr9:93564028 SYK 0.56 12.32 0.44 1.91e-31 Platelet count; BRCA cis rs10751667 0.643 rs6597970 chr11:928669 C/A cg01483505 chr11:975446 AP2A2 0.3 8.2 0.31 1.31e-15 Alzheimer's disease (late onset); BRCA cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 8.45 0.32 1.95e-16 Personality dimensions; BRCA trans rs911555 0.755 rs9671414 chr14:103967299 C/T cg17675199 chr6:35436792 RPL10A -0.3 -7.91 -0.3 1.13e-14 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg06145435 chr7:1022769 CYP2W1 0.48 8.88 0.33 6.75e-18 Bronchopulmonary dysplasia; BRCA cis rs10207060 0.771 rs4852124 chr2:240680022 C/T cg07506560 chr2:240697449 NA 0.5 11.09 0.4 2.88e-26 Obesity-related traits; BRCA cis rs17376456 0.877 rs10065056 chr5:93380123 G/T cg25358565 chr5:93447407 FAM172A 1.17 18.4 0.59 5.16e-61 Diabetic retinopathy; BRCA cis rs2882667 0.622 rs34645817 chr5:138152633 A/G cg04439458 chr5:138467593 SIL1 0.36 8.65 0.32 4.3e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2991971 0.810 rs12119202 chr1:45925931 A/T cg24296786 chr1:45957014 TESK2 -0.57 -13.32 -0.47 6.98e-36 High light scatter reticulocyte count; BRCA cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg17971929 chr21:40555470 PSMG1 -0.46 -10.24 -0.38 6.93e-23 Menarche (age at onset); BRCA cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg27478167 chr7:817139 HEATR2 -0.42 -8.97 -0.33 3.39e-18 Cerebrospinal P-tau181p levels; BRCA cis rs807669 0.505 rs2236759 chr22:19187427 C/G cg02655711 chr22:19163373 SLC25A1 0.44 10.28 0.38 4.64e-23 Metabolite levels; BRCA cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg26446133 chr18:72167187 CNDP2 -0.78 -14.01 -0.48 4.17e-39 Refractive error; BRCA cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg17892150 chr10:133769511 PPP2R2D -0.73 -15.66 -0.53 4.96e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg13736514 chr6:26305472 NA -0.37 -12.07 -0.43 2.4e-30 Educational attainment; BRCA cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs2637266 1.000 rs2395394 chr10:78360679 G/C cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg01802117 chr1:53393560 SCP2 -0.35 -7.91 -0.3 1.12e-14 Monocyte count; BRCA cis rs826838 0.935 rs1160162 chr12:38959795 G/A cg26384229 chr12:38710491 ALG10B 0.82 21.88 0.65 1.2e-79 Heart rate; BRCA cis rs1018836 0.884 rs7823461 chr8:91581075 T/C cg16814680 chr8:91681699 NA -0.64 -14.25 -0.49 3.41e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs735860 0.674 rs209485 chr6:53174448 C/T cg10236188 chr6:53219634 NA -0.4 -8.47 -0.32 1.65e-16 Glaucoma; BRCA cis rs2425143 1.000 rs78877130 chr20:34344947 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -8.9 -0.33 5.76e-18 Blood protein levels; BRCA cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg05729249 chr7:766119 PRKAR1B;HEATR2 0.54 7.83 0.3 2.07e-14 Cerebrospinal P-tau181p levels; BRCA cis rs6785206 1.000 rs6785206 chr3:128412024 A/G cg16766828 chr3:128327626 NA -0.76 -11.19 -0.4 1.12e-26 Lymphocyte percentage of white cells; BRCA cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg18252515 chr7:66147081 NA -0.56 -11.27 -0.41 5.37e-27 Corneal structure; BRCA cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg03433033 chr1:76189801 ACADM -0.47 -9.6 -0.35 1.85e-20 Daytime sleep phenotypes; BRCA cis rs2011503 1.000 rs75453386 chr19:19637781 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 8.85e-19 Bipolar disorder; BRCA cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs3008870 0.755 rs2755254 chr1:67470855 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 13.92 0.48 1.19e-38 Lymphocyte percentage of white cells; BRCA cis rs11098499 0.865 rs11722183 chr4:120280597 A/C cg09307838 chr4:120376055 NA 0.71 15.33 0.52 2.03e-45 Corneal astigmatism; BRCA cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7560272 0.538 rs4852977 chr2:73938295 C/T cg20560298 chr2:73613845 ALMS1 0.34 8.77 0.33 1.62e-17 Schizophrenia; BRCA cis rs12367572 1.000 rs10880704 chr12:45318430 C/T cg04608330 chr12:45269318 NELL2 -0.58 -12.6 -0.45 1.08e-32 Gut microbiome composition (summer); BRCA cis rs2882667 0.964 rs67296915 chr5:138301599 C/T cg04439458 chr5:138467593 SIL1 -0.32 -8.76 -0.33 1.75e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs4714291 0.832 rs1404002 chr6:40064600 C/T cg02267698 chr19:7991119 CTXN1 -0.42 -8.63 -0.32 4.96e-17 Strep throat; BRCA cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg13010199 chr12:38710504 ALG10B -0.35 -8.54 -0.32 9.47e-17 Morning vs. evening chronotype; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18402987 chr7:1209562 NA 0.65 14.25 0.49 3.38e-40 Longevity;Endometriosis; BRCA cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg05283184 chr6:79620031 NA -0.43 -11.02 -0.4 5.89e-26 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7590720 1.000 rs7559031 chr2:216902583 A/G cg12620499 chr2:216877984 MREG 0.79 22.14 0.66 4.94e-81 Alcohol dependence; BRCA cis rs6580649 1.000 rs10783227 chr12:48400617 C/T cg05342945 chr12:48394962 COL2A1 -0.49 -9.9 -0.36 1.33e-21 Lung cancer; BRCA trans rs6952808 0.609 rs6950151 chr7:1953521 T/C cg04565464 chr8:145669602 NFKBIL2 0.35 8.82 0.33 1.09e-17 Bipolar disorder and schizophrenia; BRCA cis rs6582630 0.537 rs1949610 chr12:38387838 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.45 0.38 1.06e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg10523679 chr1:76189770 ACADM -0.51 -10.0 -0.37 5.52e-22 Daytime sleep phenotypes; BRCA cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg06046430 chr4:77819534 ANKRD56 0.58 12.65 0.45 6.89e-33 Emphysema distribution in smoking; BRCA trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg17470723 chr8:74884337 TCEB1 0.42 8.92 0.33 5.03e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs9473147 0.543 rs4711878 chr6:47456118 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.6 0.36 1.77e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs35110281 0.627 rs1595167 chr21:44965874 T/G cg21573476 chr21:45109991 RRP1B -0.34 -8.77 -0.33 1.64e-17 Mean corpuscular volume; BRCA cis rs6062302 0.548 rs6089940 chr20:62252695 C/T cg16989086 chr20:62203971 PRIC285 0.53 8.84 0.33 9.3e-18 Glioblastoma; BRCA cis rs1863824 0.502 rs11202058 chr10:88282611 G/A cg07322936 chr10:88137208 NA -0.41 -7.99 -0.3 6.28e-15 Schizophrenia; BRCA trans rs6479891 1.000 rs12415984 chr10:64910288 G/A cg14819942 chr15:35414228 NA 0.35 8.58 0.32 7.2e-17 Arthritis (juvenile idiopathic); BRCA cis rs6977660 0.943 rs10254261 chr7:19846001 A/G cg05791153 chr7:19748676 TWISTNB -0.42 -8.64 -0.32 4.42e-17 Thyroid stimulating hormone; BRCA cis rs11734570 0.581 rs73808504 chr4:38600593 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.51 9.59 0.35 1.97e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2652822 0.935 rs7162825 chr15:63439186 A/G cg02713581 chr15:63449717 RPS27L -0.43 -8.67 -0.32 3.44e-17 Metabolic traits; BRCA cis rs9287719 0.649 rs9973456 chr2:10718130 C/T cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.62e-19 Prostate cancer; BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.6 -0.39 2.68e-24 Lymphocyte counts; BRCA cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg06671706 chr8:8559999 CLDN23 0.44 8.43 0.32 2.22e-16 Obesity-related traits; BRCA cis rs453301 0.719 rs34004903 chr8:8892604 C/T cg15556689 chr8:8085844 FLJ10661 -0.31 -8.13 -0.31 2.29e-15 Joint mobility (Beighton score); BRCA cis rs4948102 1.000 rs4948102 chr7:56097265 C/G cg09872392 chr7:56161020 PHKG1 -0.42 -9.49 -0.35 4.5e-20 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7666738 0.830 rs7678567 chr4:99057346 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.21 0.56 8.47e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18758796 chr5:131593413 PDLIM4 0.39 9.94 0.37 9.96e-22 Acylcarnitine levels; BRCA trans rs8002861 0.840 rs1819596 chr13:44429554 A/G cg17145862 chr1:211918768 LPGAT1 0.63 16.04 0.54 6.57e-49 Leprosy; BRCA cis rs701145 0.550 rs450115 chr3:153923418 A/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs6582630 0.621 rs10880656 chr12:38571220 A/C cg26384229 chr12:38710491 ALG10B -0.46 -10.65 -0.39 1.72e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs4948102 0.731 rs4535700 chr7:56045448 T/C cg09872392 chr7:56161020 PHKG1 -0.4 -9.08 -0.34 1.39e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7666738 0.753 rs7698541 chr4:98986351 T/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg12310025 chr6:25882481 NA -0.57 -12.89 -0.45 5.71e-34 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.21e-18 Tonsillectomy; BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg21747090 chr2:27597821 SNX17 -0.41 -8.99 -0.34 2.69e-18 Total body bone mineral density; BRCA cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg09555818 chr19:45449301 APOC2 0.47 12.22 0.44 5.4e-31 Blood protein levels; BRCA cis rs11690935 0.531 rs4280428 chr2:172813219 G/A cg13550731 chr2:172543902 DYNC1I2 0.54 13.01 0.46 1.62e-34 Schizophrenia; BRCA cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg05340658 chr4:99064831 C4orf37 0.64 14.87 0.51 3.68e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs2276314 0.857 rs8087539 chr18:33631537 C/T cg05985134 chr18:33552581 C18orf21 0.65 12.41 0.44 7.63e-32 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9486715 0.867 rs4438964 chr6:96917563 T/G cg06623918 chr6:96969491 KIAA0776 0.9 26.16 0.72 4.14e-103 Headache; BRCA cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg06221963 chr1:154839813 KCNN3 -0.6 -16.99 -0.56 1.06e-53 Prostate cancer; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -8.11 -0.31 2.6e-15 Lymphocyte counts; BRCA trans rs9329221 0.678 rs560638 chr8:9882767 A/G cg15556689 chr8:8085844 FLJ10661 -0.35 -9.18 -0.34 5.9e-19 Neuroticism; BRCA cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg05313129 chr8:58192883 C8orf71 -0.43 -8.88 -0.33 6.55e-18 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.78 -0.5 9.97e-43 Initial pursuit acceleration; BRCA cis rs9837602 0.507 rs1059905 chr3:99516879 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -12.8 -0.45 1.48e-33 Breast cancer; BRCA cis rs4363385 0.818 rs679378 chr1:153011716 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.31e-14 Inflammatory skin disease; BRCA cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg20503657 chr10:835505 NA 1.01 17.7 0.57 2.31e-57 Eosinophil percentage of granulocytes; BRCA cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg22974920 chr21:40686053 BRWD1 0.34 7.82 0.3 2.17e-14 Menarche (age at onset); BRCA cis rs4880487 0.888 rs10903405 chr10:1249498 C/G cg03183215 chr10:1252341 ADARB2 -0.38 -8.54 -0.32 9.54e-17 Migraine; BRCA cis rs2882667 0.690 rs288042 chr5:138203034 T/G cg04439458 chr5:138467593 SIL1 -0.31 -7.97 -0.3 7.3e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4713118 0.587 rs9393899 chr6:28133528 G/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.31 -0.31 5.69e-16 Parkinson's disease; BRCA cis rs2197308 0.765 rs11182992 chr12:37935572 G/C cg26384229 chr12:38710491 ALG10B 0.76 17.07 0.56 4.41e-54 Morning vs. evening chronotype; BRCA cis rs769267 1.000 rs769267 chr19:19446936 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.7 0.42 8.72e-29 Tonsillectomy; BRCA cis rs3008870 0.583 rs2815369 chr1:67500894 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.87 15.87 0.53 4.58e-48 Lymphocyte percentage of white cells; BRCA cis rs17818399 0.547 rs7607633 chr2:46759427 T/C cg02822958 chr2:46747628 ATP6V1E2 0.64 11.62 0.42 1.86e-28 Height; BRCA cis rs4908768 0.539 rs7547411 chr1:8638145 A/G cg20416874 chr1:8611966 RERE -0.28 -8.13 -0.31 2.23e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs11651000 0.857 rs16947078 chr17:45825500 A/G cg03474202 chr17:45855739 NA -0.47 -11.05 -0.4 4.46e-26 IgG glycosylation; BRCA cis rs600806 0.742 rs9429519 chr1:110017105 A/G cg20591472 chr1:110008990 SYPL2 -0.33 -8.27 -0.31 7.86e-16 Intelligence (multi-trait analysis); BRCA trans rs7824557 0.767 rs6985146 chr8:11170721 A/C cg08975724 chr8:8085496 FLJ10661 0.43 8.01 0.3 5.55e-15 Retinal vascular caliber; BRCA cis rs2901460 0.509 rs6750080 chr2:62071542 C/T cg02183531 chr2:62113199 CCT4 -0.44 -8.77 -0.33 1.65e-17 Mean corpuscular volume; BRCA cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg08999081 chr20:33150536 PIGU -0.45 -12.32 -0.44 1.83e-31 Glomerular filtration rate (creatinine); BRCA cis rs600550 0.528 rs10897006 chr11:59851874 C/G cg02771260 chr11:59836817 MS4A3 -0.53 -11.55 -0.42 3.81e-28 Lipoprotein-associated phospholipase A2 activity and mass; BRCA cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs71007656 1 rs71007656 chr10:37970845 CGGCTG/C cg25427524 chr10:38739819 LOC399744 -0.64 -14.94 -0.51 1.62e-43 Extrinsic epigenetic age acceleration; BRCA cis rs867371 0.717 rs3858954 chr15:82558034 G/C cg00614314 chr15:82944287 LOC80154 0.48 9.72 0.36 6.19e-21 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg03188948 chr7:1209495 NA 0.53 10.03 0.37 4.52e-22 Longevity;Endometriosis; BRCA cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.12 0.37 2.07e-22 Aortic root size; BRCA cis rs6700896 0.931 rs11208716 chr1:66158825 C/T cg04111102 chr1:66153794 NA 0.35 8.81 0.33 1.16e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6429082 0.689 rs10925965 chr1:235708443 C/A cg26050004 chr1:235667680 B3GALNT2 -0.52 -11.49 -0.41 6.56e-28 Adiposity; BRCA cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg26677194 chr12:130822605 PIWIL1 0.67 16.14 0.54 2.2e-49 Menopause (age at onset); BRCA cis rs12367572 0.663 rs4561266 chr12:45415763 C/T cg04608330 chr12:45269318 NELL2 -0.37 -7.93 -0.3 9.6e-15 Gut microbiome composition (summer); BRCA cis rs8062405 1.000 rs62037364 chr16:28868695 G/A cg16576597 chr16:28551801 NUPR1 0.29 8.21 0.31 1.26e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.2 0.31 1.28e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9457247 0.508 rs2285147 chr6:167505548 G/A cg07741184 chr6:167504864 NA 0.33 10.06 0.37 3.48e-22 Crohn's disease; BRCA trans rs7824557 0.564 rs7839307 chr8:11198792 A/G cg15556689 chr8:8085844 FLJ10661 0.33 9.07 0.34 1.49e-18 Retinal vascular caliber; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 17.9 0.58 2.11e-58 Alzheimer's disease; BRCA cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00475322 chr7:917719 C7orf20 0.48 12.71 0.45 3.61e-33 Perceived unattractiveness to mosquitoes; BRCA cis rs11190604 1.000 rs11190572 chr10:102232879 A/G cg07080220 chr10:102295463 HIF1AN 0.48 11.1 0.4 2.65e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg25319279 chr11:5960081 NA -0.41 -8.08 -0.3 3.36e-15 DNA methylation (variation); BRCA cis rs12611088 0.571 rs8110232 chr19:44027390 T/C cg15012607 chr19:44012195 ETHE1 -0.34 -8.83 -0.33 9.95e-18 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg22907277 chr7:1156413 C7orf50 0.37 8.3 0.31 6.18e-16 Longevity;Endometriosis; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.65 13.42 0.47 2.28e-36 Lymphocyte counts; BRCA cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg13319975 chr6:146136371 FBXO30 0.34 8.0 0.3 5.98e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs939658 0.728 rs8031638 chr15:79422726 C/T cg17916960 chr15:79447300 NA -0.42 -9.77 -0.36 4.08e-21 Refractive error; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg17366294 chr4:99064904 C4orf37 0.44 10.23 0.38 7.37e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1005277 0.505 rs200931 chr10:38128434 A/C cg25427524 chr10:38739819 LOC399744 -0.67 -16.05 -0.54 5.72e-49 Extrinsic epigenetic age acceleration; BRCA cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg26061582 chr7:22766209 IL6 0.38 8.89 0.33 6.27e-18 Lung cancer; BRCA cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg18225595 chr11:63971243 STIP1 0.52 9.46 0.35 6.01e-20 Mean platelet volume; BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg13047869 chr3:10149882 C3orf24 0.6 12.91 0.45 5.02e-34 Alzheimer's disease; BRCA cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg24110177 chr3:50126178 RBM5 0.42 11.59 0.42 2.5e-28 Intelligence (multi-trait analysis); BRCA cis rs7178424 0.967 rs72749770 chr15:62365465 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.24 -0.31 1.01e-15 Height; BRCA cis rs332507 0.711 rs3772793 chr3:124405723 A/G cg05980111 chr3:124395277 KALRN 0.37 8.63 0.32 4.83e-17 Plateletcrit; BRCA cis rs6500602 0.855 rs1139652 chr16:4476089 T/C cg08645402 chr16:4508243 NA 0.36 8.0 0.3 5.68e-15 Schizophrenia; BRCA cis rs4820294 0.961 rs62236664 chr22:38059427 T/C cg21798802 chr22:38057573 PDXP 0.5 13.24 0.46 1.6e-35 Fat distribution (HIV); BRCA cis rs2439831 0.850 rs2277531 chr15:44069069 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.87 0.43 1.61e-29 Lung cancer in ever smokers; BRCA cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg10295955 chr4:187884368 NA -0.99 -31.64 -0.78 6.55e-133 Lobe attachment (rater-scored or self-reported); BRCA cis rs9790314 0.663 rs7632423 chr3:160738728 A/G cg03342759 chr3:160939853 NMD3 0.44 9.15 0.34 7.66e-19 Morning vs. evening chronotype; BRCA cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg22974920 chr21:40686053 BRWD1 0.39 8.81 0.33 1.18e-17 Cognitive function; BRCA cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.67e-36 Chronic sinus infection; BRCA cis rs7937890 1.000 rs2970335 chr11:14325401 A/C cg22961513 chr11:14280813 SPON1 -0.31 -8.07 -0.3 3.58e-15 Mitochondrial DNA levels; BRCA cis rs2404602 0.692 rs2117369 chr15:76748861 A/T cg26408565 chr15:76604113 ETFA -0.48 -10.31 -0.38 3.72e-23 Blood metabolite levels; BRCA cis rs7560272 0.512 rs2421677 chr2:73965917 G/T cg20560298 chr2:73613845 ALMS1 0.33 8.44 0.32 2.08e-16 Schizophrenia; BRCA cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg18357645 chr12:58087776 OS9 0.36 10.14 0.37 1.72e-22 Multiple sclerosis; BRCA cis rs11229555 0.645 rs35735990 chr11:58187371 G/A cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.05e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.68 -10.45 -0.38 1.08e-23 Schizophrenia; BRCA cis rs7520050 0.966 rs11211241 chr1:46452683 T/A cg24296786 chr1:45957014 TESK2 0.44 9.81 0.36 2.89e-21 Red blood cell count;Reticulocyte count; BRCA cis rs3087591 0.887 rs2905875 chr17:29541339 A/T cg24425628 chr17:29625626 OMG;NF1 0.46 9.32 0.35 1.88e-19 Hip circumference; BRCA cis rs832540 0.629 rs10940512 chr5:56082094 G/C cg18230493 chr5:56204884 C5orf35 -0.45 -9.32 -0.35 1.91e-19 Coronary artery disease; BRCA cis rs1949733 0.675 rs2688235 chr4:8450546 T/C cg11789530 chr4:8429930 ACOX3 0.59 14.56 0.5 1.07e-41 Response to antineoplastic agents; BRCA cis rs4535700 0.501 rs10245725 chr7:55976548 C/T cg09872392 chr7:56161020 PHKG1 -0.35 -8.05 -0.3 4.16e-15 Macular telangiectasia type 2; BRCA cis rs1005277 0.540 rs11011351 chr10:38030525 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -10.16 -0.37 1.38e-22 Extrinsic epigenetic age acceleration; BRCA cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg12386194 chr3:101231763 SENP7 0.41 8.67 0.32 3.49e-17 Colorectal cancer; BRCA cis rs12464559 0.522 rs4664498 chr2:152575417 A/G cg01189475 chr2:152685088 ARL5A 0.51 7.92 0.3 1.04e-14 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs17401966 0.931 rs12130563 chr1:10428452 G/A cg03954927 chr1:10346856 KIF1B 0.48 14.82 0.51 6.34e-43 Hepatocellular carcinoma; BRCA cis rs724568 0.508 rs1430773 chr2:67943520 G/A cg14046302 chr2:67939758 NA -0.41 -11.08 -0.4 3.23e-26 Major depressive disorder (broad); BRCA cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg25173405 chr17:45401733 C17orf57 -0.49 -9.71 -0.36 7.12e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs3733585 0.605 rs4697710 chr4:10122649 T/C cg26043149 chr18:55253948 FECH -0.37 -7.86 -0.3 1.67e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs757081 0.667 rs17561348 chr11:17161615 C/T cg15432903 chr11:17409602 KCNJ11 0.45 8.46 0.32 1.81e-16 Systolic blood pressure; BRCA cis rs11051970 0.879 rs2088807 chr12:32592101 C/G cg24626660 chr12:32551988 NA 0.3 8.43 0.32 2.3e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg04166393 chr7:2884313 GNA12 0.61 12.61 0.45 9.83e-33 Height; BRCA cis rs4713118 0.824 rs9468229 chr6:27750086 G/A cg20933634 chr6:27740509 NA 0.49 9.82 0.36 2.62e-21 Parkinson's disease; BRCA trans rs7746199 0.736 rs13212318 chr6:27688841 A/C cg06606381 chr12:133084897 FBRSL1 -0.89 -8.8 -0.33 1.3e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg26031613 chr14:104095156 KLC1 0.74 16.01 0.54 8.85e-49 Body mass index; BRCA cis rs703842 0.616 rs10783851 chr12:58231155 A/G cg00677455 chr12:58241039 CTDSP2 -0.75 -16.85 -0.55 5.63e-53 Multiple sclerosis; BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg26516362 chr5:178986906 RUFY1 0.36 9.86 0.36 1.89e-21 Lung cancer; BRCA cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg15212455 chr7:39170539 POU6F2 0.44 9.82 0.36 2.6e-21 IgG glycosylation; BRCA trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg24838063 chr12:130822603 PIWIL1 0.69 16.86 0.55 4.67e-53 Menopause (age at onset); BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg13628971 chr7:2884303 GNA12 0.44 9.11 0.34 1.07e-18 Height; BRCA cis rs3772130 0.923 rs7649092 chr3:121561950 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.82 0.39 3.58e-25 Cognitive performance; BRCA cis rs7587476 0.906 rs2070096 chr2:215645545 C/G cg04004882 chr2:215674386 BARD1 0.6 10.57 0.39 3.67e-24 Neuroblastoma; BRCA cis rs12989701 0.825 rs4663097 chr2:127861906 C/G cg08168897 chr2:127865431 BIN1 -0.6 -11.18 -0.4 1.28e-26 Alzheimer's disease (late onset); BRCA cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg26769984 chr7:1090371 C7orf50 0.65 11.47 0.41 8.13e-28 Bronchopulmonary dysplasia; BRCA cis rs1568889 1.000 rs12802830 chr11:28321196 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 12.74 0.45 2.79e-33 Bipolar disorder; BRCA cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg04586622 chr2:25135609 ADCY3 -0.49 -11.58 -0.42 2.67e-28 Body mass index; BRCA cis rs2882667 0.654 rs12517514 chr5:138150119 A/G cg04439458 chr5:138467593 SIL1 0.31 7.92 0.3 1.09e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg18876405 chr7:65276391 NA 0.55 13.35 0.47 4.99e-36 Aortic root size; BRCA cis rs3768617 0.811 rs12738377 chr1:183031256 C/T ch.1.3577855R chr1:183094577 LAMC1 0.44 9.47 0.35 5.13e-20 Fuchs's corneal dystrophy; BRCA cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg08045932 chr20:61659980 NA 0.49 11.32 0.41 3.4e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg26874164 chr19:58962979 ZNF324B 0.47 10.0 0.37 5.74e-22 Uric acid clearance; BRCA cis rs7267979 1.000 rs4815421 chr20:25386509 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.06 -0.34 1.53e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs950776 0.518 rs8053 chr15:78841220 T/C cg06917634 chr15:78832804 PSMA4 -0.75 -17.55 -0.57 1.45e-56 Sudden cardiac arrest; BRCA cis rs698813 0.674 rs6544752 chr2:44499049 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.45 7.89 0.3 1.36e-14 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg07636037 chr3:49044803 WDR6 0.79 19.47 0.61 1.23e-66 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs35146811 0.844 rs4424195 chr7:99642745 A/G cg13334819 chr7:99746414 C7orf59 -0.38 -9.42 -0.35 8.17e-20 Coronary artery disease; BRCA cis rs1949733 0.628 rs2688231 chr4:8490981 G/A cg13073564 chr4:8508604 NA -0.39 -10.41 -0.38 1.56e-23 Response to antineoplastic agents; BRCA cis rs10752881 0.967 rs4652757 chr1:182974750 T/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs8058578 1.000 rs8051050 chr16:30687909 A/G cg02466173 chr16:30829666 NA -0.53 -11.44 -0.41 1.03e-27 Multiple myeloma; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg21226059 chr5:178986404 RUFY1 0.39 10.29 0.38 4.4e-23 Lung cancer; BRCA cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.64 10.01 0.37 5.23e-22 Lung function (FEV1/FVC); BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg23285459 chr7:2802560 GNA12 -0.34 -8.6 -0.32 6.34e-17 Height; BRCA cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg00321850 chr1:175162397 KIAA0040 0.43 12.38 0.44 1.05e-31 Alcohol dependence; BRCA trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.49 -0.47 1.09e-36 Extrinsic epigenetic age acceleration; BRCA cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg00074818 chr8:8560427 CLDN23 -0.36 -7.87 -0.3 1.52e-14 Obesity-related traits; BRCA cis rs34779708 0.733 rs11010146 chr10:35541561 T/A cg03585969 chr10:35415529 CREM 0.45 9.19 0.34 5.23e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg13319975 chr6:146136371 FBXO30 -0.36 -8.29 -0.31 6.79e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11112613 0.713 rs11112589 chr12:105951226 C/G cg03607813 chr12:105948248 NA -0.55 -10.6 -0.39 2.78e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs28374715 0.578 rs72739630 chr15:41631064 G/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -23.42 -0.68 5.04e-88 Ulcerative colitis; BRCA cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg21770322 chr7:97807741 LMTK2 0.45 11.74 0.42 5.91e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs2304069 0.837 rs10041451 chr5:149385197 A/C cg10852222 chr5:149380144 HMGXB3;TIGD6 0.56 8.7 0.33 2.7e-17 HIV-1 control; BRCA cis rs9733 0.519 rs12095002 chr1:150649249 G/A cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs1580019 0.922 rs766658 chr7:32499391 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.6 0.32 6.35e-17 Cognitive ability; BRCA cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.0 -0.37 5.55e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs7904368 0.754 rs12253908 chr10:16853358 T/C cg23933602 chr10:16859644 RSU1 0.57 8.93 0.33 4.47e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg08847533 chr14:75593920 NEK9 -0.95 -25.11 -0.7 2.47e-97 Height; BRCA trans rs11098499 0.865 rs10032158 chr4:120391632 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.97 0.3 7.33e-15 Corneal astigmatism; BRCA cis rs11971779 0.941 rs7802779 chr7:139122579 G/T cg07862535 chr7:139043722 LUC7L2 0.41 10.58 0.39 3.19e-24 Diisocyanate-induced asthma; BRCA cis rs4363385 0.818 rs946095 chr1:153006470 T/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.28 -0.34 2.53e-19 Inflammatory skin disease; BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 14.09 0.49 1.89e-39 Lymphocyte counts; BRCA trans rs7615952 0.866 rs11922276 chr3:125631326 G/T cg07211511 chr3:129823064 LOC729375 -1.01 -19.21 -0.61 3.06e-65 Blood pressure (smoking interaction); BRCA cis rs35146811 0.624 rs1727134 chr7:99813672 T/C cg13334819 chr7:99746414 C7orf59 0.4 9.17 0.34 6.36e-19 Coronary artery disease; BRCA cis rs7582720 1.000 rs72934545 chr2:203975958 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.77 0.45 2.02e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs698813 0.674 rs11680456 chr2:44497544 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 8.9 0.33 5.59e-18 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs4319547 0.656 rs10773075 chr12:122814236 G/A cg23029597 chr12:123009494 RSRC2 -0.59 -11.4 -0.41 1.52e-27 Body mass index; BRCA cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.6 0.42 2.25e-28 Homoarginine levels; BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg00080972 chr5:178986291 RUFY1 -0.35 -9.06 -0.34 1.58e-18 Lung cancer; BRCA cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg25811766 chr13:21894605 NA 0.61 10.92 0.4 1.44e-25 White matter hyperintensity burden; BRCA cis rs6456156 0.586 rs9459862 chr6:167487011 A/G cg07741184 chr6:167504864 NA -0.3 -8.94 -0.33 4.21e-18 Primary biliary cholangitis; BRCA cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs2882667 0.728 rs10037071 chr5:138277847 A/G cg04439458 chr5:138467593 SIL1 -0.32 -8.23 -0.31 1.05e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1801251 1.000 rs6437074 chr2:233712296 C/T cg08000102 chr2:233561755 GIGYF2 -0.59 -12.42 -0.44 7.29e-32 Coronary artery disease; BRCA cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg12935359 chr14:103987150 CKB -0.59 -14.08 -0.49 2.02e-39 Body mass index; BRCA cis rs16958440 1.000 rs62096476 chr18:44658621 T/C cg17192377 chr18:44677553 HDHD2 0.69 10.1 0.37 2.41e-22 Sitting height ratio; BRCA cis rs478304 0.627 rs11604568 chr11:65511336 G/A cg10518572 chr11:65560635 OVOL1 -0.28 -8.1 -0.31 2.71e-15 Acne (severe); BRCA trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg27661571 chr11:113659931 NA -0.83 -12.11 -0.43 1.55e-30 Hip circumference adjusted for BMI; BRCA cis rs921968 0.643 rs4674321 chr2:219511368 G/A cg02176678 chr2:219576539 TTLL4 0.43 11.46 0.41 8.52e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg26395211 chr5:140044315 WDR55 0.38 8.57 0.32 8.04e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs17401966 0.838 rs4846212 chr1:10370312 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.7 0.48 1.18e-37 Hepatocellular carcinoma; BRCA cis rs1371867 0.846 rs1660329 chr8:101304048 G/T cg06002616 chr8:101225028 SPAG1 -0.34 -8.34 -0.31 4.47e-16 Atrioventricular conduction; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg25703541 chr22:24373054 LOC391322 0.63 13.56 0.47 5.17e-37 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10754283 0.934 rs7529653 chr1:90111851 G/A cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.21 -0.43 5.68e-31 Gut microbiome composition (summer); BRCA cis rs7385804 0.761 rs576236 chr7:100316975 C/T cg20848291 chr7:100343083 ZAN 0.37 8.26 0.31 8.4e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs4660306 0.961 rs7539253 chr1:45947420 C/T cg24296786 chr1:45957014 TESK2 0.42 8.39 0.32 3.08e-16 Homocysteine levels; BRCA cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.68e-18 Motion sickness; BRCA trans rs61931739 0.534 rs11053049 chr12:34164537 T/C cg26384229 chr12:38710491 ALG10B 0.69 14.65 0.5 4.31e-42 Morning vs. evening chronotype; BRCA cis rs7246657 0.551 rs4806414 chr19:37638788 T/C cg23950597 chr19:37808831 NA -0.62 -9.48 -0.35 4.75e-20 Coronary artery calcification; BRCA cis rs2832077 0.943 rs2272701 chr21:30190907 C/T cg08807101 chr21:30365312 RNF160 -0.47 -7.97 -0.3 7.37e-15 Cognitive test performance; BRCA cis rs875971 0.862 rs709609 chr7:65560561 A/G cg11764359 chr7:65958608 NA -0.74 -16.15 -0.54 1.86e-49 Aortic root size; BRCA cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg12310025 chr6:25882481 NA 0.5 12.07 0.43 2.41e-30 Blood metabolite levels; BRCA cis rs17685 0.753 rs8200 chr7:75696606 C/G cg16489192 chr7:75678113 MDH2;STYXL1 0.4 9.09 0.34 1.2e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg03188948 chr7:1209495 NA 0.68 11.33 0.41 2.99e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2625529 0.730 rs4777485 chr15:72389384 G/C cg16672083 chr15:72433130 SENP8 -0.76 -17.12 -0.56 2.41e-54 Red blood cell count; BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.21 -0.31 1.19e-15 Total body bone mineral density; BRCA cis rs9467773 0.595 rs4320356 chr6:26423560 C/T cg09904177 chr6:26538194 HMGN4 -0.37 -9.77 -0.36 4.15e-21 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg16606324 chr3:10149918 C3orf24 0.57 11.38 0.41 1.87e-27 Alzheimer's disease; BRCA cis rs7149337 1.000 rs8006432 chr14:51731306 A/T cg23942311 chr14:51606299 NA 0.37 10.05 0.37 3.8e-22 Cancer; BRCA trans rs208520 0.690 rs207091 chr6:66799847 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.01 -0.64 6.5e-75 Exhaled nitric oxide output; BRCA cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg12927641 chr6:109611667 NA -0.43 -10.98 -0.4 7.9e-26 Reticulocyte fraction of red cells; BRCA cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg05084668 chr3:125655381 ALG1L -0.47 -8.14 -0.31 2.08e-15 Blood pressure (smoking interaction); BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg09177884 chr7:1199841 ZFAND2A -0.59 -14.03 -0.49 3.61e-39 Longevity;Endometriosis; BRCA cis rs2652834 0.808 rs28583444 chr15:63357852 T/G cg05507819 chr15:63340323 TPM1 0.53 9.18 0.34 6.07e-19 HDL cholesterol; BRCA cis rs10782582 0.609 rs1498311 chr1:76254726 A/C cg03433033 chr1:76189801 ACADM 0.39 7.91 0.3 1.11e-14 Daytime sleep phenotypes; BRCA cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.78 0.42 4.07e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.42 0.47 2.35e-36 Colorectal cancer; BRCA cis rs1035144 0.524 rs8009260 chr14:81408591 G/T cg06600135 chr14:81408086 NA 0.44 10.61 0.39 2.54e-24 Male sexual orientation; BRCA cis rs10752881 1.000 rs6658501 chr1:182991417 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.62 -16.59 -0.55 1.17e-51 Colorectal cancer; BRCA cis rs60871478 0.947 rs62432866 chr7:809281 T/G cg04727924 chr7:799746 HEATR2 -0.55 -10.85 -0.39 2.85e-25 Cerebrospinal P-tau181p levels; BRCA cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg02297831 chr4:17616191 MED28 0.36 8.46 0.32 1.88e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 0.532 rs4833624 chr4:120585497 C/T cg25214090 chr10:38739885 LOC399744 0.46 10.11 0.37 2.25e-22 Corneal astigmatism; BRCA cis rs7927771 0.524 rs7942074 chr11:47720509 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.46 0.35 5.7e-20 Subjective well-being; BRCA cis rs4766646 0.640 rs4766640 chr12:110300147 C/T cg01252219 chr12:110302105 GLTP -0.38 -8.11 -0.31 2.52e-15 Metabolite levels (MHPG); BRCA cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg23029597 chr12:123009494 RSRC2 -0.59 -11.54 -0.42 4.27e-28 Body mass index; BRCA cis rs561341 1.000 rs501312 chr17:30329066 A/G cg23018236 chr17:30244563 NA -0.63 -10.24 -0.38 6.8e-23 Hip circumference adjusted for BMI; BRCA cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.07e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA trans rs10838798 0.504 rs1483123 chr11:48326773 G/A cg15704280 chr7:45808275 SEPT13 -0.42 -8.28 -0.31 7.29e-16 Height; BRCA cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.35 8.2 0.31 1.33e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg22974920 chr21:40686053 BRWD1 -0.4 -8.97 -0.33 3.14e-18 Cognitive function; BRCA cis rs6089584 0.821 rs4925332 chr20:60604639 C/T cg06108461 chr20:60628389 TAF4 -0.97 -21.26 -0.64 2.94e-76 Body mass index; BRCA cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.48 0.52 3.92e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs965469 0.779 rs6139048 chr20:3239753 T/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.7 -0.33 2.78e-17 IFN-related cytopenia; BRCA cis rs9837602 0.529 rs793459 chr3:99520591 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.4 -0.52 1.02e-45 Breast cancer; BRCA cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.38 0.49 8.4e-41 Colorectal cancer; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg02951883 chr7:2050386 MAD1L1 -0.55 -12.43 -0.44 6.65e-32 Bipolar disorder and schizophrenia; BRCA cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg06212747 chr3:49208901 KLHDC8B 0.49 10.29 0.38 4.3e-23 Parkinson's disease; BRCA cis rs4642101 0.793 rs12714880 chr3:12832101 G/A cg24848339 chr3:12840334 CAND2 0.45 12.15 0.43 1.03e-30 QRS complex (12-leadsum); BRCA trans rs6952808 0.609 rs4721190 chr7:1954732 A/G cg04565464 chr8:145669602 NFKBIL2 -0.44 -10.52 -0.38 5.44e-24 Bipolar disorder and schizophrenia; BRCA cis rs875971 0.755 rs10228885 chr7:65780529 C/G cg11764359 chr7:65958608 NA -0.75 -16.8 -0.55 9.56e-53 Aortic root size; BRCA cis rs911119 1.000 rs6114209 chr20:23622266 G/C cg16589663 chr20:23618590 CST3 0.46 8.52 0.32 1.14e-16 Chronic kidney disease; BRCA trans rs17685 0.753 rs10476 chr7:75696420 C/T cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.5 -0.74 1.99e-110 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg20503657 chr10:835505 NA 1.03 15.66 0.53 4.91e-47 Eosinophil percentage of granulocytes; BRCA cis rs1832871 0.672 rs6933928 chr6:158747071 C/T cg07165851 chr6:158734300 TULP4 0.63 12.61 0.45 9.79e-33 Height; BRCA cis rs2070488 0.775 rs2300669 chr3:38541318 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.57 -15.03 -0.51 6.02e-44 Electrocardiographic conduction measures; BRCA cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg15448220 chr1:150897856 SETDB1 0.35 7.99 0.3 6.16e-15 Melanoma; BRCA cis rs6987853 0.787 rs2923442 chr8:42435493 T/C cg09913449 chr8:42400586 C8orf40 0.42 9.29 0.35 2.33e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs317689 0.513 rs317659 chr12:69686132 T/A cg20891283 chr12:69753455 YEATS4 0.48 11.16 0.4 1.45e-26 Response to diuretic therapy; BRCA cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.56 -0.45 1.64e-32 Developmental language disorder (linguistic errors); BRCA cis rs250677 0.522 rs6580589 chr5:148360335 C/G cg12140854 chr5:148520817 ABLIM3 0.41 8.32 0.31 5.16e-16 Breast cancer; BRCA cis rs2066819 1.000 rs59811639 chr12:56695954 C/T cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg19717773 chr7:2847554 GNA12 -0.43 -9.64 -0.36 1.28e-20 Height; BRCA trans rs6582630 0.519 rs8189599 chr12:38280748 A/G cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg03354898 chr7:1950403 MAD1L1 -0.44 -9.24 -0.34 3.74e-19 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA trans rs2749592 0.611 rs176888 chr10:38406161 C/A cg17830980 chr10:43048298 ZNF37B -0.39 -7.86 -0.3 1.68e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9633740 1.000 rs7910643 chr10:82251769 G/A cg01528321 chr10:82214614 TSPAN14 1.04 20.09 0.62 5.78e-70 Post bronchodilator FEV1; BRCA cis rs6598955 0.671 rs6658935 chr1:26568912 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 15.15 0.51 1.65e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6835098 0.962 rs6851632 chr4:174109611 A/G cg27433088 chr4:174089019 GALNT7 0.34 9.24 0.34 3.48e-19 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -13.14 -0.46 4.35e-35 Chronic sinus infection; BRCA cis rs4713675 0.565 rs4713659 chr6:33667839 A/G cg14003231 chr6:33640908 ITPR3 0.35 8.92 0.33 5.01e-18 Plateletcrit; BRCA cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg13298116 chr11:62369859 EML3;MTA2 0.58 13.44 0.47 1.88e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6543140 0.964 rs10196334 chr2:103090041 T/C cg04239558 chr2:103089729 SLC9A4 0.36 9.99 0.37 6.11e-22 Blood protein levels; BRCA trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg03929089 chr4:120376271 NA -0.44 -8.25 -0.31 9.12e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs6120849 0.707 rs6088690 chr20:33633326 A/G cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs250677 0.687 rs250667 chr5:148455134 A/G cg18129178 chr5:148520854 ABLIM3 0.61 12.5 0.44 3.15e-32 Breast cancer; BRCA cis rs55883249 1.000 rs11692112 chr2:9723732 G/T cg23886495 chr2:9695866 ADAM17 0.55 7.93 0.3 9.48e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg12927641 chr6:109611667 NA -0.42 -10.85 -0.39 2.81e-25 Reticulocyte fraction of red cells; BRCA cis rs738322 0.935 rs2413503 chr22:38568944 A/T cg25457927 chr22:38595422 NA -0.31 -11.75 -0.42 5.33e-29 Cutaneous nevi; BRCA cis rs72781680 0.950 rs72796343 chr2:24147631 G/A cg08917208 chr2:24149416 ATAD2B 1.12 15.97 0.53 1.45e-48 Lymphocyte counts; BRCA cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.4 -0.44 8.19e-32 Bipolar disorder; BRCA trans rs3780486 0.846 rs6476399 chr9:33123013 A/G cg04842962 chr6:43655489 MRPS18A 1.12 38.33 0.83 8.9e-168 IgG glycosylation; BRCA cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.13e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg24596788 chr1:163392923 NA 0.37 10.31 0.38 3.85e-23 Motion sickness; BRCA cis rs11098499 0.865 rs28634456 chr4:120375778 A/G cg09307838 chr4:120376055 NA 0.74 16.02 0.54 8.64e-49 Corneal astigmatism; BRCA cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.44 -8.25 -0.31 8.95e-16 Renal function-related traits (BUN); BRCA cis rs11764590 0.694 rs60626033 chr7:2099719 A/G cg23422044 chr7:1970798 MAD1L1 -0.44 -9.47 -0.35 5.33e-20 Neuroticism; BRCA cis rs4819052 0.632 rs4819050 chr21:46692943 C/A cg11663144 chr21:46675770 NA -0.47 -10.97 -0.4 9.13e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs7737355 0.898 rs32109 chr5:131041590 C/T cg06307176 chr5:131281290 NA 0.53 10.73 0.39 8.26e-25 Life satisfaction; BRCA cis rs3008870 0.755 rs4655662 chr1:67416432 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.65 14.09 0.49 1.88e-39 Lymphocyte percentage of white cells; BRCA cis rs796364 0.951 rs36086821 chr2:201067436 G/A cg23649088 chr2:200775458 C2orf69 0.61 10.58 0.39 3.19e-24 Schizophrenia; BRCA trans rs4650994 0.525 rs4650991 chr1:178511165 C/T cg05059571 chr16:84539110 KIAA1609 -0.56 -12.76 -0.45 2.19e-33 HDL cholesterol levels;HDL cholesterol; BRCA cis rs10791097 0.967 rs6590512 chr11:130717916 A/G cg12179176 chr11:130786555 SNX19 -0.55 -12.2 -0.43 6.6e-31 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.67 0.74 2.28e-111 Chronic sinus infection; BRCA trans rs35110281 0.776 rs229357 chr21:44982717 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.43 0.38 1.21e-23 Mean corpuscular volume; BRCA cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg18357645 chr12:58087776 OS9 -0.33 -7.99 -0.3 6.21e-15 Multiple sclerosis; BRCA cis rs3099143 1.000 rs4583202 chr15:77161676 G/A cg21673338 chr15:77095150 SCAPER 0.52 9.19 0.34 5.25e-19 Recalcitrant atopic dermatitis; BRCA cis rs2762353 0.935 rs1165209 chr6:25801319 G/A cg12310025 chr6:25882481 NA -0.5 -11.96 -0.43 7.16e-30 Blood metabolite levels; BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg16145915 chr7:1198662 ZFAND2A -0.44 -8.89 -0.33 6.28e-18 Bronchopulmonary dysplasia; BRCA cis rs7172677 0.737 rs12910348 chr15:75437642 A/G cg10253484 chr15:75165896 SCAMP2 -0.45 -8.35 -0.31 4.37e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs11039798 0.588 rs6485857 chr11:48556511 C/A cg15704280 chr7:45808275 SEPT13 0.53 8.97 0.33 3.33e-18 Axial length; BRCA cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.59e-23 Motion sickness; BRCA cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg06115741 chr20:33292138 TP53INP2 -0.38 -8.38 -0.31 3.25e-16 Glomerular filtration rate (creatinine); BRCA cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg24675658 chr1:53192096 ZYG11B 0.63 15.2 0.52 8.74e-45 Monocyte count; BRCA cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg06784218 chr1:46089804 CCDC17 -0.51 -12.49 -0.44 3.62e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13108904 0.846 rs12643212 chr4:1224948 A/G cg05665937 chr4:1216051 CTBP1 0.49 9.88 0.36 1.66e-21 Obesity-related traits; BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg27170947 chr2:26402098 FAM59B -0.8 -13.0 -0.46 1.96e-34 Gut microbiome composition (summer); BRCA cis rs875971 0.862 rs778680 chr7:65840414 G/A cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs9733 0.519 rs72704603 chr1:150707992 C/T cg17724175 chr1:150552817 MCL1 0.26 8.71 0.33 2.69e-17 Tonsillectomy; BRCA cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg05623727 chr3:50126028 RBM5 0.51 12.48 0.44 3.7e-32 Intelligence (multi-trait analysis); BRCA cis rs2180341 0.883 rs7760748 chr6:127690062 C/T cg27446573 chr6:127587934 RNF146 0.86 19.7 0.61 7.62e-68 Breast cancer; BRCA cis rs9814567 1.000 rs6800862 chr3:134228628 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.31 -0.35 2.07e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2204008 0.744 rs2222344 chr12:38406832 T/G cg26384229 chr12:38710491 ALG10B 0.69 16.25 0.54 6.19e-50 Bladder cancer; BRCA cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs2289583 0.500 rs67168917 chr15:75391494 G/T cg14664628 chr15:75095509 CSK 0.35 7.83 0.3 2.02e-14 Systemic lupus erythematosus; BRCA cis rs7246657 0.722 rs2972438 chr19:38210847 A/G cg18154014 chr19:37997991 ZNF793 0.47 8.83 0.33 1.02e-17 Coronary artery calcification; BRCA cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg02018176 chr4:1364513 KIAA1530 0.4 8.31 0.31 5.76e-16 Longevity; BRCA cis rs7512552 0.839 rs2867894 chr1:150452912 T/A cg15654264 chr1:150340011 RPRD2 0.37 8.12 0.31 2.34e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs8038465 0.638 rs8036954 chr15:73974282 T/C cg15420318 chr15:73925796 NPTN 0.42 9.33 0.35 1.68e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.17 -0.37 1.31e-22 Initial pursuit acceleration; BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg18758796 chr5:131593413 PDLIM4 0.33 8.73 0.33 2.19e-17 Breast cancer; BRCA cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg24675658 chr1:53192096 ZYG11B 0.68 14.68 0.5 2.81e-42 Monocyte count; BRCA cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg12311346 chr5:56204834 C5orf35 0.62 13.01 0.46 1.64e-34 Initial pursuit acceleration; BRCA cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg11843238 chr5:131593191 PDLIM4 0.36 7.96 0.3 7.92e-15 Breast cancer; BRCA cis rs3772130 0.962 rs9826473 chr3:121556219 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.81 0.39 4.06e-25 Cognitive performance; BRCA cis rs9443189 0.570 rs661229 chr6:76293793 G/A cg01950844 chr6:76311363 SENP6 0.85 14.09 0.49 1.84e-39 Prostate cancer; BRCA cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.36 8.33 0.31 5.09e-16 Coronary artery disease; BRCA cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg05890377 chr2:74357713 NA 0.36 8.09 0.3 3e-15 Gestational age at birth (maternal effect); BRCA cis rs7727544 0.904 rs7736102 chr5:131604257 G/A cg14196790 chr5:131705035 SLC22A5 0.31 8.03 0.3 4.82e-15 Blood metabolite levels; BRCA cis rs3820928 0.874 rs13393894 chr2:227880543 A/G cg11843606 chr2:227700838 RHBDD1 -0.36 -8.03 -0.3 4.57e-15 Pulmonary function; BRCA cis rs1577917 0.883 rs13212415 chr6:86608083 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.34 -8.97 -0.33 3.31e-18 Response to antipsychotic treatment; BRCA cis rs10824037 0.673 rs11000789 chr10:75595226 T/G cg07699608 chr10:75541558 CHCHD1 0.5 8.04 0.3 4.39e-15 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4862307 0.808 rs7666346 chr4:185000657 G/A cg06737308 chr4:185021514 ENPP6 -0.38 -8.23 -0.31 1.04e-15 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg16339924 chr4:17578868 LAP3 0.76 18.09 0.58 2.25e-59 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7824557 0.806 rs7007394 chr8:11094566 G/A cg06636001 chr8:8085503 FLJ10661 -0.47 -9.32 -0.35 1.89e-19 Retinal vascular caliber; BRCA cis rs2249625 0.874 rs2463697 chr6:72838760 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -7.88 -0.3 1.41e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -17.04 -0.56 5.76e-54 Chronic sinus infection; BRCA cis rs9486719 0.790 rs2499790 chr6:96845078 G/A cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs10876993 0.928 rs2169988 chr12:58071165 G/A cg18357645 chr12:58087776 OS9 0.48 13.69 0.48 1.4e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs7646881 0.812 rs61387735 chr3:158456161 G/A cg19483011 chr3:158453295 NA -0.47 -8.3 -0.31 6.28e-16 Tetralogy of Fallot; BRCA cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg01262667 chr19:19385393 TM6SF2 0.41 10.55 0.39 4.18e-24 Tonsillectomy; BRCA cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA trans rs11088226 0.681 rs2833899 chr21:33933263 T/C cg09050820 chr6:167586206 TCP10L2 0.77 13.25 0.46 1.4e-35 Gastritis; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg15112475 chr7:1198522 ZFAND2A -0.6 -14.24 -0.49 3.86e-40 Longevity;Endometriosis; BRCA cis rs4819052 0.679 rs2255761 chr21:46683622 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.5 11.17 0.4 1.41e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7589728 0.858 rs1914734 chr2:88529509 T/C cg04511125 chr2:88470314 THNSL2 0.58 9.38 0.35 1.15e-19 Plasma clusterin levels; BRCA cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.73e-18 Motion sickness; BRCA cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg15017067 chr4:17643749 FAM184B 0.28 8.28 0.31 7.23e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.41 0.41 1.4e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs727479 0.502 rs2289106 chr15:51507782 T/G cg19946085 chr15:51559439 CYP19A1 -0.3 -8.38 -0.31 3.38e-16 Estradiol levels; BRCA cis rs6580649 0.941 rs1793931 chr12:48396505 G/T cg05342945 chr12:48394962 COL2A1 -0.49 -9.84 -0.36 2.38e-21 Lung cancer; BRCA cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2304069 0.909 rs2544931 chr5:149367837 C/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.85 -16.22 -0.54 8.79e-50 HIV-1 control; BRCA trans rs11098499 0.866 rs12374352 chr4:120281977 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 18.49 0.59 1.81e-61 Alzheimer's disease; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.17 -0.34 6.4e-19 Menopause (age at onset); BRCA cis rs13102973 0.965 rs28799927 chr4:135867094 A/G cg14419869 chr4:135874104 NA -0.59 -12.99 -0.46 2.06e-34 Subjective well-being; BRCA cis rs12973672 1.000 rs10410675 chr19:35768828 T/C cg12095397 chr19:35769544 USF2 0.37 8.31 0.31 5.95e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs2197308 0.765 rs11182964 chr12:37935052 C/T cg06521331 chr12:34319734 NA -0.53 -9.52 -0.35 3.46e-20 Morning vs. evening chronotype; BRCA cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg11266682 chr4:10021025 SLC2A9 0.37 9.97 0.37 7.71e-22 Bone mineral density; BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg01262667 chr19:19385393 TM6SF2 0.41 10.61 0.39 2.55e-24 Tonsillectomy; BRCA cis rs77861329 1.000 rs352148 chr3:52208898 A/G cg08692210 chr3:52188851 WDR51A 0.75 11.38 0.41 1.95e-27 Macrophage inflammatory protein 1b levels; BRCA cis rs2239547 0.657 rs4687672 chr3:52880543 G/A cg11645453 chr3:52864694 ITIH4 0.48 11.71 0.42 8.24e-29 Schizophrenia; BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.55 11.12 0.4 2.14e-26 Tonsillectomy; BRCA cis rs6460942 0.841 rs17443848 chr7:12443688 A/G cg10578991 chr7:12443926 VWDE -0.5 -8.61 -0.32 5.55e-17 Coronary artery disease; BRCA cis rs17767294 0.708 rs34957169 chr6:27879397 T/C cg08851530 chr6:28072375 NA 0.92 8.91 0.33 5.15e-18 Parkinson's disease; BRCA cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.3 -0.49 1.91e-40 Hemoglobin concentration; BRCA cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg18225595 chr11:63971243 STIP1 0.5 8.9 0.33 5.64e-18 Mean platelet volume; BRCA cis rs2336384 1.000 rs4846085 chr1:12050634 T/C cg13216073 chr1:12042593 MFN2 0.44 9.66 0.36 1.11e-20 Platelet count; BRCA cis rs2637266 1.000 rs6480824 chr10:78355705 G/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs4660306 0.961 rs4660868 chr1:45986497 A/G cg24296786 chr1:45957014 TESK2 0.43 8.66 0.32 3.96e-17 Homocysteine levels; BRCA cis rs68170813 0.559 rs74584447 chr7:106944755 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.64 -0.32 4.46e-17 Coronary artery disease; BRCA cis rs8062405 0.964 rs72793809 chr16:28832382 C/T cg16576597 chr16:28551801 NUPR1 0.3 8.42 0.32 2.52e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7829975 0.846 rs7005216 chr8:8547110 C/G cg15556689 chr8:8085844 FLJ10661 -0.38 -10.74 -0.39 7.54e-25 Mood instability; BRCA cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.17 0.31 1.67e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg25036284 chr2:26402008 FAM59B -0.64 -10.59 -0.39 3.03e-24 Gut microbiome composition (summer); BRCA cis rs4662945 0.603 rs2406981 chr2:130305487 A/G cg05903289 chr2:130345205 NA -0.34 -8.48 -0.32 1.59e-16 Response to cytidine analogues (gemcitabine); BRCA cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 3.95e-25 Bipolar disorder; BRCA trans rs1997103 1.000 rs6957984 chr7:55397331 G/A cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9814567 1.000 rs9826496 chr3:134224437 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.56 -0.61 4.23e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg21280719 chr6:42927975 GNMT 0.33 13.9 0.48 1.46e-38 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs61931739 0.853 rs10844751 chr12:34099651 T/G cg26384229 chr12:38710491 ALG10B -0.44 -10.37 -0.38 2.23e-23 Morning vs. evening chronotype; BRCA trans rs3857536 0.741 rs2097679 chr6:66937994 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs1707322 1.000 rs785510 chr1:46528618 T/C cg03146154 chr1:46216737 IPP -0.47 -10.29 -0.38 4.34e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6429082 0.818 rs61836206 chr1:235638754 C/G cg26050004 chr1:235667680 B3GALNT2 0.57 13.44 0.47 1.95e-36 Adiposity; BRCA cis rs4819052 0.851 rs13047104 chr21:46673562 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.0 0.48 4.84e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg16145915 chr7:1198662 ZFAND2A -0.45 -8.41 -0.32 2.7e-16 Bronchopulmonary dysplasia; BRCA cis rs9837602 0.748 rs9289985 chr3:99878116 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.53 -8.78 -0.33 1.53e-17 Breast cancer; BRCA cis rs2075671 0.903 rs11520986 chr7:100276994 A/G cg20848291 chr7:100343083 ZAN -0.58 -12.53 -0.44 2.2e-32 Other erythrocyte phenotypes; BRCA cis rs312273 0.967 rs1442187 chr12:41251039 C/T cg17827154 chr12:41323612 CNTN1 -0.42 -10.07 -0.37 2.96e-22 Bipolar disorder; BRCA cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg11833968 chr6:79620685 NA -0.4 -8.9 -0.33 5.7e-18 Intelligence (multi-trait analysis); BRCA cis rs9467773 1.000 rs1321479 chr6:26501897 C/T cg09904177 chr6:26538194 HMGN4 -0.48 -14.97 -0.51 1.23e-43 Intelligence (multi-trait analysis); BRCA cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg23887609 chr12:130822674 PIWIL1 0.43 9.33 0.35 1.71e-19 Menopause (age at onset); BRCA cis rs7395581 1.000 rs830085 chr11:47251199 G/A cg25783544 chr11:47291846 MADD -0.44 -9.7 -0.36 7.65e-21 HDL cholesterol; BRCA cis rs9311474 1.000 rs9311474 chr3:52338852 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.26 7.87 0.3 1.56e-14 Electroencephalogram traits; BRCA cis rs870825 0.616 rs2003994 chr4:185636568 G/T cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs6570726 0.935 rs425731 chr6:145834151 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7474896 0.537 rs1779068 chr10:38250785 G/A cg25427524 chr10:38739819 LOC399744 0.53 9.63 0.36 1.35e-20 Obesity (extreme); BRCA cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg00012203 chr2:219082015 ARPC2 -0.48 -9.18 -0.34 5.88e-19 Colorectal cancer; BRCA cis rs7918232 0.943 rs6482593 chr10:27371437 A/G cg14240646 chr10:27532245 ACBD5 -0.65 -10.06 -0.37 3.25e-22 Breast cancer; BRCA cis rs4363385 0.818 rs377768 chr1:153016594 T/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.83 -0.33 1.04e-17 Inflammatory skin disease; BRCA cis rs9790314 0.905 rs4856739 chr3:160986710 A/C cg03342759 chr3:160939853 NMD3 -0.65 -14.14 -0.49 1.05e-39 Morning vs. evening chronotype; BRCA cis rs10751667 0.666 rs7394992 chr11:980690 G/C cg10932868 chr11:921992 NA 0.49 12.21 0.43 5.68e-31 Alzheimer's disease (late onset); BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg12311346 chr5:56204834 C5orf35 -0.65 -12.42 -0.44 7.21e-32 Initial pursuit acceleration; BRCA cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg03146154 chr1:46216737 IPP 0.53 11.54 0.42 4.24e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs910316 0.763 rs175044 chr14:75472109 G/A cg11812906 chr14:75593930 NEK9 -0.6 -13.69 -0.48 1.29e-37 Height; BRCA cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg11644478 chr21:40555479 PSMG1 -0.54 -11.6 -0.42 2.34e-28 Menarche (age at onset); BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.33e-19 Tonsillectomy; BRCA cis rs4588572 0.606 rs6859161 chr5:77742776 A/G cg11547950 chr5:77652471 NA -0.45 -8.58 -0.32 7.33e-17 Triglycerides; BRCA cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg13866156 chr1:1669148 SLC35E2 -0.46 -10.18 -0.37 1.18e-22 Body mass index; BRCA cis rs6430585 1.000 rs73958618 chr2:136500475 A/G cg07169764 chr2:136633963 MCM6 1.03 21.82 0.65 2.53e-79 Corneal structure; BRCA cis rs40363 0.645 rs250629 chr16:3525431 C/A cg00484396 chr16:3507460 NAT15 0.44 9.29 0.34 2.43e-19 Tuberculosis; BRCA cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg25036284 chr2:26402008 FAM59B -0.64 -11.03 -0.4 5.3e-26 Gut microbiome composition (summer); BRCA cis rs1707322 0.686 rs1547924 chr1:46085112 C/T cg03146154 chr1:46216737 IPP 0.51 11.32 0.41 3.23e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2797160 1.000 rs1630556 chr6:126013155 A/G cg05039488 chr6:79577232 IRAK1BP1 0.35 7.89 0.3 1.35e-14 Endometrial cancer; BRCA cis rs7092929 0.883 rs611890 chr10:3585733 T/C cg14308648 chr10:3568949 NA 0.45 8.15 0.31 1.98e-15 Coronary artery calcification; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg08888203 chr3:10149979 C3orf24 0.64 13.06 0.46 9.81e-35 Alzheimer's disease; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg04025307 chr7:1156635 C7orf50 0.59 9.36 0.35 1.33e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg12016809 chr21:47604291 C21orf56 0.38 7.92 0.3 1.09e-14 Testicular germ cell tumor; BRCA cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -10.45 -0.38 1.03e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8114671 0.869 rs66535333 chr20:33656666 G/A cg07148914 chr20:33460835 GGT7 -0.42 -9.11 -0.34 1.09e-18 Height; BRCA cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg14847009 chr1:175162515 KIAA0040 -0.25 -9.25 -0.34 3.33e-19 Alcohol dependence; BRCA cis rs10493773 0.502 rs12061951 chr1:86081453 A/G cg17807903 chr1:86174739 ZNHIT6 -0.42 -8.63 -0.32 4.92e-17 Urate levels in overweight individuals; BRCA cis rs7091957 1.000 rs7091957 chr10:134439478 C/T cg27286337 chr10:134555280 INPP5A 0.47 8.95 0.33 3.81e-18 Gait speed in old age; BRCA cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.88 -0.3 1.4e-14 Colorectal cancer; BRCA cis rs7408868 0.764 rs12610803 chr19:15260682 A/C cg14696996 chr19:15285081 NOTCH3 0.96 14.34 0.49 1.17e-40 Pulse pressure; BRCA cis rs950169 0.512 rs4374136 chr15:84645007 C/G cg17507749 chr15:85114479 UBE2QP1 0.49 7.99 0.3 6.34e-15 Schizophrenia; BRCA cis rs1011018 0.628 rs4074826 chr7:139415943 G/A cg03224163 chr7:139420300 HIPK2 -0.54 -8.84 -0.33 9.06e-18 Systolic blood pressure; BRCA cis rs6964587 0.655 rs6965864 chr7:91595596 A/G cg17063962 chr7:91808500 NA 0.55 12.64 0.45 7.77e-33 Breast cancer; BRCA cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg12386194 chr3:101231763 SENP7 0.39 8.34 0.31 4.56e-16 Colorectal cancer; BRCA trans rs17685 0.753 rs1637045 chr7:75703895 T/C cg19862616 chr7:65841803 NCRNA00174 0.86 28.57 0.75 2.5e-116 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs17685 0.712 rs28456330 chr7:75810542 A/G cg19862616 chr7:65841803 NCRNA00174 0.8 25.28 0.71 3.05e-98 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.44 0.66 1.16e-82 Chronic sinus infection; BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 8.47 0.32 1.68e-16 Platelet count; BRCA cis rs7737355 1.000 rs6876350 chr5:130604109 G/T cg06307176 chr5:131281290 NA 0.47 9.22 0.34 4.3e-19 Life satisfaction; BRCA cis rs73086581 1.000 rs6107386 chr20:3972756 A/C cg02187196 chr20:3869020 PANK2 0.51 8.89 0.33 6.09e-18 Response to antidepressants in depression; BRCA cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.48 -9.68 -0.36 9.26e-21 Tonsillectomy; BRCA cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -8.59 -0.32 6.42e-17 Schizophrenia; BRCA cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg12011299 chr4:100065546 ADH4 0.43 11.39 0.41 1.66e-27 Alcohol dependence; BRCA cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11644478 chr21:40555479 PSMG1 -0.7 -15.8 -0.53 1.01e-47 Cognitive function; BRCA cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg22117172 chr7:91764530 CYP51A1 0.23 7.9 0.3 1.19e-14 Breast cancer; BRCA cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg17971929 chr21:40555470 PSMG1 -0.6 -13.35 -0.47 4.68e-36 Cognitive function; BRCA cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -19.08 -0.6 1.37e-64 Initial pursuit acceleration; BRCA cis rs6582630 0.502 rs12815350 chr12:38439921 A/T cg13010199 chr12:38710504 ALG10B 0.48 9.72 0.36 6.47e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg11366901 chr6:160182831 ACAT2 -0.78 -15.29 -0.52 3.18e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs7903847 0.642 rs12258560 chr10:99137048 T/C cg20016023 chr10:99160130 RRP12 -0.27 -8.64 -0.32 4.43e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg18876405 chr7:65276391 NA -0.5 -10.98 -0.4 8.51e-26 Aortic root size; BRCA cis rs514406 0.729 rs534070 chr1:53308858 T/G cg27535305 chr1:53392650 SCP2 -0.46 -11.38 -0.41 1.82e-27 Monocyte count; BRCA cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.72 0.36 6.67e-21 Bipolar disorder; BRCA cis rs3768617 0.510 rs4651140 chr1:183096952 G/T ch.1.3577855R chr1:183094577 LAMC1 0.66 17.5 0.57 2.46e-56 Fuchs's corneal dystrophy; BRCA cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg23711669 chr6:146136114 FBXO30 0.71 17.09 0.56 3.21e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs3916 0.794 rs10431386 chr12:121128926 A/G cg21892295 chr12:121157589 UNC119B 0.33 9.32 0.35 1.86e-19 Urinary metabolites (H-NMR features); BRCA cis rs8180040 0.654 rs13078131 chr3:47204939 G/T cg16586182 chr3:47516702 SCAP -0.56 -12.92 -0.46 4.48e-34 Colorectal cancer; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg03354898 chr7:1950403 MAD1L1 -0.48 -9.96 -0.37 8.31e-22 Bipolar disorder and schizophrenia; BRCA cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg19077165 chr18:44547161 KATNAL2 -0.59 -13.09 -0.46 7.67e-35 Personality dimensions; BRCA cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg23788917 chr6:8435910 SLC35B3 0.47 10.24 0.38 6.7e-23 Motion sickness; BRCA cis rs78707713 0.560 rs2394563 chr10:71238618 G/A cg12610070 chr10:71211762 TSPAN15 -0.33 -10.03 -0.37 4.25e-22 Venous thromboembolism; BRCA cis rs9811920 0.638 rs793503 chr3:99588070 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.37 -8.35 -0.31 4.35e-16 Axial length; BRCA cis rs4074536 0.622 rs10923440 chr1:116317441 G/A cg21648376 chr1:116311395 CASQ2 -0.56 -9.29 -0.34 2.48e-19 QRS duration; BRCA cis rs708547 0.533 rs3806746 chr4:57773330 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.34 -8.46 -0.32 1.89e-16 Response to bleomycin (chromatid breaks); BRCA cis rs7246657 0.943 rs9917081 chr19:37876616 T/C cg23950597 chr19:37808831 NA -0.72 -12.51 -0.44 2.9e-32 Coronary artery calcification; BRCA cis rs61990749 0.597 rs176980 chr14:78198449 C/G cg23188588 chr14:78226832 SNW1;C14orf178 -0.43 -7.82 -0.3 2.18e-14 Fibroblast growth factor basic levels; BRCA trans rs60843830 1.000 rs7595075 chr2:264019 C/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 14.52 0.5 1.73e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg06634786 chr22:41940651 POLR3H 0.62 10.52 0.38 5.37e-24 Vitiligo; BRCA cis rs829883 0.867 rs1641640 chr12:98896017 A/G cg25150519 chr12:98850993 NA 0.59 11.9 0.43 1.19e-29 Colorectal adenoma (advanced); BRCA cis rs698833 0.561 rs698808 chr2:44701901 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.6 0.32 5.98e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs763014 1.000 rs7205409 chr16:642610 A/G cg07256732 chr16:621771 PIGQ -0.35 -9.38 -0.35 1.1e-19 Height; BRCA cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg26031613 chr14:104095156 KLC1 -0.42 -8.45 -0.32 1.94e-16 Schizophrenia; BRCA cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.76 0.42 4.77e-29 Schizophrenia; BRCA cis rs9914988 0.943 rs1035989 chr17:27143810 T/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.81 -0.33 1.13e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs67981189 0.574 rs2526848 chr14:71419742 T/C cg15816911 chr14:71606274 NA -0.37 -8.36 -0.31 3.98e-16 Schizophrenia; BRCA cis rs1499614 1.000 rs2707830 chr7:66167645 T/C cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg13010199 chr12:38710504 ALG10B 0.42 8.84 0.33 8.99e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs4853036 0.629 rs921712 chr2:70017103 G/T cg02498382 chr2:70120550 SNRNP27 -0.42 -7.87 -0.3 1.55e-14 Colorectal or endometrial cancer; BRCA trans rs8073060 0.544 rs7210966 chr17:33986334 G/C cg19694781 chr19:47549865 TMEM160 -1.05 -22.93 -0.67 2.22e-85 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs17253792 0.545 rs35418987 chr14:56017407 T/G cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs2637266 1.000 rs2579746 chr10:78327674 C/T cg18941641 chr10:78392320 NA 0.35 7.96 0.3 8.01e-15 Pulmonary function; BRCA cis rs7267979 1.000 rs2258879 chr20:25279213 T/C cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg11814155 chr7:99998594 ZCWPW1 0.58 9.8 0.36 3.16e-21 Platelet count; BRCA cis rs941408 1.000 rs1640271 chr19:2799979 C/T cg06609049 chr19:2785107 THOP1 0.54 11.37 0.41 2.08e-27 Total cholesterol levels; BRCA cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.16e-15 Uric acid levels; BRCA cis rs7927592 0.913 rs12363722 chr11:68236291 A/C cg20283391 chr11:68216788 NA -0.47 -9.15 -0.34 7.86e-19 Total body bone mineral density; BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs1451375 1.000 rs6949897 chr7:50621920 C/T cg18232548 chr7:50535776 DDC 0.43 10.13 0.37 1.88e-22 Malaria; BRCA trans rs6582630 0.519 rs1851130 chr12:38507819 C/T cg06521331 chr12:34319734 NA -0.46 -8.65 -0.32 4.26e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7267979 1.000 rs910997 chr20:25267301 G/A cg08601574 chr20:25228251 PYGB 0.35 8.43 0.32 2.33e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg08470875 chr2:26401718 FAM59B -0.62 -9.25 -0.34 3.21e-19 Gut microbiome composition (summer); BRCA cis rs6028335 0.674 rs59072291 chr20:37622010 T/A cg16355469 chr20:37678765 NA 0.5 9.03 0.34 1.97e-18 Alcohol and nicotine co-dependence; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg22920501 chr2:26401640 FAM59B 0.65 11.31 0.41 3.62e-27 Gut microbiome composition (summer); BRCA trans rs61931739 0.534 rs11053020 chr12:34111092 C/G cg13010199 chr12:38710504 ALG10B 0.47 9.18 0.34 5.96e-19 Morning vs. evening chronotype; BRCA trans rs61931739 0.517 rs4931748 chr12:34140827 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.27 0.34 2.76e-19 Morning vs. evening chronotype; BRCA cis rs1577917 1.000 rs12216328 chr6:86703418 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.19 -0.46 2.51e-35 Response to antipsychotic treatment; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg24101359 chr6:42928495 GNMT 0.66 16.61 0.55 8.79e-52 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4233802 1.000 rs6761697 chr2:151141735 A/G cg25300694 chr2:151184358 NA 0.7 7.9 0.3 1.25e-14 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7246967 0.673 rs62120313 chr19:22877183 G/C cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs739401 0.611 rs402276 chr11:3051404 C/G cg08508325 chr11:3079039 CARS -0.43 -15.58 -0.52 1.2e-46 Longevity; BRCA cis rs6866344 0.697 rs11749438 chr5:178131245 C/T cg10224037 chr5:178157518 ZNF354A 0.77 16.29 0.54 3.9e-50 Neutrophil percentage of white cells; BRCA cis rs870825 0.655 rs67798981 chr4:185619567 A/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg12386194 chr3:101231763 SENP7 0.46 9.88 0.36 1.6e-21 Colorectal cancer; BRCA cis rs10751667 0.643 rs10794352 chr11:946294 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.71 0.55 2.69e-52 Alzheimer's disease (late onset); BRCA cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg13880726 chr7:1868755 MAD1L1 0.4 8.11 0.31 2.56e-15 Bipolar disorder and schizophrenia; BRCA cis rs10752881 0.809 rs3768613 chr1:183106296 G/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.32 0.54 2.53e-50 Colorectal cancer; BRCA trans rs7819412 0.561 rs2001328 chr8:10987199 T/C cg06636001 chr8:8085503 FLJ10661 -0.46 -9.61 -0.36 1.58e-20 Triglycerides; BRCA cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.78 13.06 0.46 1.02e-34 Schizophrenia; BRCA trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg06606381 chr12:133084897 FBRSL1 -0.71 -7.97 -0.3 7.11e-15 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg23583168 chr7:148888333 NA -0.76 -17.59 -0.57 9.07e-57 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg24250549 chr1:154909240 PMVK 0.61 15.35 0.52 1.69e-45 Prostate cancer; BRCA cis rs838147 0.760 rs12979144 chr19:49237547 G/A cg12258179 chr19:49232187 RASIP1 0.33 8.17 0.31 1.61e-15 Dietary macronutrient intake; BRCA cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg24642439 chr20:33292090 TP53INP2 -0.54 -11.76 -0.42 4.81e-29 Glomerular filtration rate (creatinine); BRCA cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.54e-84 Chronic sinus infection; BRCA trans rs12505749 1.000 rs17756240 chr4:57355192 G/C cg09583921 chr3:87101925 NA 0.79 9.87 0.36 1.81e-21 Airflow obstruction; BRCA cis rs10267417 0.584 rs10247789 chr7:19863570 G/C cg05791153 chr7:19748676 TWISTNB 0.49 9.64 0.36 1.24e-20 Night sleep phenotypes; BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg16606324 chr3:10149918 C3orf24 0.51 9.86 0.36 1.98e-21 Alzheimer's disease; BRCA trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg08975724 chr8:8085496 FLJ10661 0.4 8.1 0.31 2.83e-15 Neuroticism; BRCA cis rs9527 0.637 rs7096169 chr10:104618695 A/G cg04362960 chr10:104952993 NT5C2 0.42 10.02 0.37 4.63e-22 Arsenic metabolism; BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg13628971 chr7:2884303 GNA12 0.57 12.03 0.43 3.47e-30 Height; BRCA cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg06713675 chr4:122721982 EXOSC9 -0.35 -8.08 -0.3 3.18e-15 Type 2 diabetes; BRCA cis rs7927771 0.524 rs10838758 chr11:47771476 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs9788682 0.747 rs28511883 chr15:78783683 C/T cg24631222 chr15:78858424 CHRNA5 0.46 9.06 0.34 1.6e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs12348691 0.503 rs1348386 chr9:100612807 A/G cg13688889 chr9:100608707 NA -0.48 -9.98 -0.37 6.71e-22 Alopecia areata; BRCA trans rs4332037 0.707 rs73046323 chr7:1882795 G/A cg11693508 chr17:37793320 STARD3 0.59 11.02 0.4 5.72e-26 Bipolar disorder; BRCA cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg22800045 chr5:56110881 MAP3K1 0.65 12.34 0.44 1.62e-31 Initial pursuit acceleration; BRCA cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs7408868 0.908 rs10418660 chr19:15278635 A/G cg14696996 chr19:15285081 NOTCH3 1.0 14.52 0.5 1.76e-41 Pulse pressure; BRCA cis rs11690935 0.959 rs6433314 chr2:172660971 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -28.45 -0.75 1.19e-115 Schizophrenia; BRCA cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg16339924 chr4:17578868 LAP3 0.66 16.94 0.56 1.87e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12142240 0.698 rs56049453 chr1:46835468 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.46 0.32 1.81e-16 Menopause (age at onset); BRCA trans rs1994135 0.617 rs10844642 chr12:33730368 A/C cg26384229 chr12:38710491 ALG10B 0.48 10.14 0.37 1.68e-22 Resting heart rate; BRCA cis rs1401999 0.650 rs3749445 chr3:183638506 C/T cg20387954 chr3:183756860 HTR3D 0.39 8.82 0.33 1.08e-17 Anterior chamber depth; BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.5 0.68 1.78e-88 Platelet count; BRCA cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg22535103 chr8:58192502 C8orf71 -0.57 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA trans rs931812 0.757 rs34988706 chr8:101907062 C/T cg20993868 chr7:22813445 NA 0.45 13.42 0.47 2.29e-36 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00166722 chr3:10149974 C3orf24 0.65 12.93 0.46 3.7e-34 Alzheimer's disease; BRCA cis rs9443645 0.901 rs9448580 chr6:79551812 C/G cg11833968 chr6:79620685 NA -0.41 -9.44 -0.35 6.69e-20 Intelligence (multi-trait analysis); BRCA cis rs7172677 0.501 rs56266638 chr15:75393205 T/A cg14664628 chr15:75095509 CSK 0.39 9.1 0.34 1.1e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7267979 1.000 rs6083804 chr20:25317060 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.78 -0.36 3.81e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -18.14 -0.58 1.24e-59 Initial pursuit acceleration; BRCA cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg20203395 chr5:56204925 C5orf35 -0.47 -8.05 -0.3 3.95e-15 Type 2 diabetes; BRCA cis rs35995292 0.500 rs6955677 chr7:38933942 C/T cg19327137 chr7:38886074 VPS41 0.38 12.67 0.45 5.76e-33 Subjective well-being (multi-trait analysis); BRCA trans rs7618501 0.633 rs6792892 chr3:49995518 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.44 0.35 6.71e-20 Intelligence (multi-trait analysis); BRCA cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg04034577 chr2:241836375 C2orf54 0.56 13.67 0.48 1.6e-37 Urinary metabolites; BRCA cis rs6545883 0.929 rs2600663 chr2:61540687 A/G cg15711740 chr2:61764176 XPO1 0.52 13.27 0.46 1.12e-35 Tuberculosis; BRCA cis rs9649213 0.537 rs6971825 chr7:97979548 C/T cg21770322 chr7:97807741 LMTK2 0.45 11.7 0.42 8.56e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.720 rs6704498 chr1:152964740 C/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.3 -0.35 2.12e-19 Inflammatory skin disease; BRCA cis rs933688 1.000 rs985434 chr5:90744509 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.1 0.62 5.33e-70 Smoking behavior; BRCA cis rs1401999 1.000 rs1401999 chr3:183678342 C/G cg01324343 chr3:183735012 ABCC5 0.83 20.88 0.64 3.3e-74 Anterior chamber depth; BRCA cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg10802521 chr3:52805072 NEK4 -0.33 -8.48 -0.32 1.61e-16 Bipolar disorder; BRCA cis rs7818345 0.967 rs4546679 chr8:19283335 C/A cg11303988 chr8:19266685 CSGALNACT1 0.31 8.22 0.31 1.12e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs9287719 0.810 rs7601748 chr2:10785446 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.97 -0.3 7.47e-15 Prostate cancer; BRCA cis rs7707921 0.767 rs6880209 chr5:81574182 C/T cg15871215 chr5:81402204 ATG10 -0.36 -8.35 -0.31 4.26e-16 Breast cancer; BRCA cis rs6910061 1.000 rs6938870 chr6:11095317 A/G cg27233058 chr6:11094804 LOC221710 0.52 9.31 0.35 1.94e-19 Diabetic kidney disease; BRCA cis rs875971 0.929 rs778712 chr7:65849978 C/T cg18876405 chr7:65276391 NA 0.55 13.33 0.47 6.05e-36 Aortic root size; BRCA cis rs2668423 0.501 rs502121 chr19:1387299 T/C cg02639931 chr19:1387894 NDUFS7 -0.85 -21.92 -0.66 7.3e-80 Nonalcoholic fatty liver disease; BRCA cis rs2197308 0.765 rs7295711 chr12:37903631 C/T cg13010199 chr12:38710504 ALG10B 0.51 9.99 0.37 6.28e-22 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg27170947 chr2:26402098 FAM59B -0.64 -11.38 -0.41 1.91e-27 Gut microbiome composition (summer); BRCA cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg22974920 chr21:40686053 BRWD1 -0.38 -8.76 -0.33 1.71e-17 Cognitive function; BRCA cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg06238570 chr21:40685208 BRWD1 -0.43 -8.41 -0.32 2.65e-16 Cognitive function; BRCA cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03264133 chr6:25882463 NA -0.74 -17.17 -0.56 1.24e-54 Blood metabolite levels; BRCA cis rs1577917 0.958 rs11756510 chr6:86699794 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.33 -0.47 6.12e-36 Response to antipsychotic treatment; BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.09 -0.3 2.98e-15 Total body bone mineral density; BRCA cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg23719950 chr11:63933701 MACROD1 -0.5 -8.62 -0.32 5.42e-17 Mean platelet volume; BRCA cis rs6582630 0.599 rs12824838 chr12:38373584 G/T cg26384229 chr12:38710491 ALG10B -0.39 -9.15 -0.34 7.29e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs9361491 0.580 rs13204088 chr6:79757438 A/C cg09184832 chr6:79620586 NA -0.44 -8.66 -0.32 3.93e-17 Intelligence (multi-trait analysis); BRCA cis rs3857067 0.806 rs4560373 chr4:95113229 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs4631830 0.863 rs2843549 chr10:51521247 C/A cg20129853 chr10:51489980 NA -0.28 -7.84 -0.3 1.88e-14 Prostate-specific antigen levels; BRCA cis rs2011503 1.000 rs8110171 chr19:19560063 C/T cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg24324837 chr19:49891574 CCDC155 0.46 8.35 0.31 4.1e-16 Multiple sclerosis; BRCA cis rs870825 0.860 rs11132253 chr4:185595472 C/T cg04058563 chr4:185651563 MLF1IP 0.66 11.78 0.42 3.82e-29 Blood protein levels; BRCA cis rs17376456 0.877 rs13173952 chr5:93307557 A/T cg25358565 chr5:93447407 FAM172A 1.14 18.39 0.59 6.32e-61 Diabetic retinopathy; BRCA cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.6 0.32 6.24e-17 Platelet count; BRCA cis rs2012796 1.000 rs10450939 chr14:81825202 A/T cg02996355 chr14:81879375 NA 0.5 9.79 0.36 3.63e-21 Night sleep phenotypes; BRCA cis rs897080 0.515 rs698800 chr2:44690787 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.16 0.34 7.04e-19 Height; BRCA cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.52 13.6 0.47 3.57e-37 Response to bleomycin (chromatid breaks); BRCA trans rs8073060 0.586 rs225257 chr17:33956625 G/A cg19694781 chr19:47549865 TMEM160 -1.06 -21.35 -0.65 9.65e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs250677 0.687 rs40149 chr5:148444275 A/T cg12140854 chr5:148520817 ABLIM3 -0.41 -8.51 -0.32 1.2e-16 Breast cancer; BRCA cis rs9467773 1.000 rs1884946 chr6:26545308 C/G cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.76e-20 Intelligence (multi-trait analysis); BRCA cis rs6740322 0.948 rs6715072 chr2:43562230 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -11.78 -0.42 3.87e-29 Coronary artery disease; BRCA cis rs868036 1.000 rs6494696 chr15:68103206 C/G cg08079166 chr15:68083412 MAP2K5 -0.34 -9.12 -0.34 9.75e-19 Restless legs syndrome; BRCA cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.27e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7617773 0.780 rs4541431 chr3:48365218 G/C cg11946769 chr3:48343235 NME6 0.67 13.61 0.47 3.13e-37 Coronary artery disease; BRCA cis rs922182 1.000 rs922182 chr15:64277642 C/T cg24729988 chr15:64271149 DAPK2 0.44 9.73 0.36 5.88e-21 Blood protein levels; BRCA cis rs9308433 0.643 rs4655330 chr1:214466068 A/G cg06198575 chr1:214491504 SMYD2 -0.49 -10.42 -0.38 1.33e-23 IgG glycosylation; BRCA cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg13175981 chr1:150552382 MCL1 0.53 11.77 0.42 4.36e-29 Tonsillectomy; BRCA cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg02659138 chr7:134003124 SLC35B4 0.34 10.54 0.38 4.49e-24 Mean platelet volume; BRCA cis rs9462027 0.628 rs9469863 chr6:34739649 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.01 -0.3 5.4e-15 Systemic lupus erythematosus; BRCA cis rs10193935 1.000 rs4494804 chr2:42395946 A/T cg27598129 chr2:42591480 NA -0.93 -14.94 -0.51 1.59e-43 Colonoscopy-negative controls vs population controls; BRCA trans rs7178375 1.000 rs9806159 chr15:31209654 G/T cg04373760 chr16:53404718 NA 0.46 8.95 0.33 3.77e-18 Hypertriglyceridemia; BRCA cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg15485101 chr11:133734466 NA 0.38 10.59 0.39 2.88e-24 Childhood ear infection; BRCA cis rs7523273 0.606 rs761275 chr1:207972154 A/C cg22525895 chr1:207977042 MIR29B2 -0.5 -12.68 -0.45 5.09e-33 Schizophrenia; BRCA cis rs35146811 0.700 rs858513 chr7:99825558 G/A cg13334819 chr7:99746414 C7orf59 0.39 8.96 0.33 3.49e-18 Coronary artery disease; BRCA cis rs6543140 1.000 rs6543140 chr2:103074274 G/T cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg18876405 chr7:65276391 NA -0.54 -12.43 -0.44 6.23e-32 Aortic root size; BRCA cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg06115741 chr20:33292138 TP53INP2 0.39 8.59 0.32 6.82e-17 Glomerular filtration rate (creatinine); BRCA cis rs652260 0.663 rs580984 chr19:7881030 C/T cg26014689 chr19:7917955 EVI5L -0.45 -10.0 -0.37 5.71e-22 Menarche (age at onset); BRCA cis rs1577917 0.958 rs12190603 chr6:86475718 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.4 -0.44 8.65e-32 Response to antipsychotic treatment; BRCA cis rs2997447 0.655 rs2275947 chr1:26383875 A/G cg19633962 chr1:26362018 EXTL1 -0.47 -8.48 -0.32 1.59e-16 QRS complex (12-leadsum); BRCA cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg03709012 chr19:19516395 GATAD2A 0.78 17.72 0.57 2e-57 Tonsillectomy; BRCA cis rs5997397 0.967 rs5752791 chr22:29153547 A/G cg02153584 chr22:29168773 CCDC117 -0.47 -10.48 -0.38 8.1e-24 Red cell distribution width; BRCA cis rs11690935 0.959 rs11904009 chr2:172627343 T/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.67 -0.77 1.01e-127 Schizophrenia; BRCA cis rs67478160 0.643 rs12878868 chr14:104233725 G/A cg08213375 chr14:104286397 PPP1R13B 0.64 18.25 0.59 3.14e-60 Schizophrenia; BRCA cis rs2276314 0.857 rs28379448 chr18:33604364 C/A cg19628046 chr18:33552617 C18orf21 0.53 9.97 0.37 7.18e-22 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1034435 0.755 rs713923 chr22:48891519 C/T cg05992904 chr22:48892994 FAM19A5 0.7 16.31 0.54 2.95e-50 Late-onset Alzheimer's disease; BRCA cis rs1499972 0.941 rs55779525 chr3:117651483 A/C cg07612923 chr3:117604196 NA 0.6 8.11 0.31 2.61e-15 Schizophrenia; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs6430585 0.528 rs6750549 chr2:136707480 A/G cg07169764 chr2:136633963 MCM6 1.27 26.48 0.72 7.65e-105 Corneal structure; BRCA trans rs9951602 0.512 rs7234283 chr18:76640552 T/G cg02800362 chr5:177631904 HNRNPAB 0.76 17.67 0.57 3.37e-57 Obesity-related traits; BRCA cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg17366294 chr4:99064904 C4orf37 0.41 9.33 0.35 1.72e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs597539 0.654 rs655816 chr11:68626405 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.41 0.54 9.31e-51 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs6456156 0.586 rs12529876 chr6:167461501 G/A cg07741184 chr6:167504864 NA 0.33 9.8 0.36 3.32e-21 Primary biliary cholangitis; BRCA cis rs6840360 0.615 rs12503677 chr4:152610543 A/G cg22705602 chr4:152727874 NA -0.37 -10.01 -0.37 5.03e-22 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.935 rs446242 chr6:145843866 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.17 0.51 1.28e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg22974920 chr21:40686053 BRWD1 -0.39 -8.54 -0.32 9.74e-17 Cognitive function; BRCA trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg15556689 chr8:8085844 FLJ10661 0.38 10.0 0.37 5.54e-22 Retinal vascular caliber; BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg08888203 chr3:10149979 C3orf24 0.68 14.45 0.5 3.52e-41 Alzheimer's disease; BRCA cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg00012203 chr2:219082015 ARPC2 -0.48 -9.27 -0.34 2.75e-19 Colorectal cancer; BRCA cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg11764359 chr7:65958608 NA -0.67 -15.1 -0.51 2.69e-44 Aortic root size; BRCA cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg02297831 chr4:17616191 MED28 0.36 8.35 0.31 4.15e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4728302 0.559 rs12707093 chr7:133200817 C/T cg10665199 chr7:133106180 EXOC4 0.43 8.63 0.32 4.96e-17 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs10751667 0.714 rs7396700 chr11:963863 A/C ch.11.42038R chr11:967971 AP2A2 0.52 16.62 0.55 8.25e-52 Alzheimer's disease (late onset); BRCA cis rs9443645 0.527 rs9352663 chr6:79558164 T/C cg05283184 chr6:79620031 NA -0.37 -8.57 -0.32 7.53e-17 Intelligence (multi-trait analysis); BRCA cis rs12762955 0.528 rs10903358 chr10:1102386 G/A cg10556349 chr10:835070 NA 0.58 8.1 0.31 2.86e-15 Response to angiotensin II receptor blocker therapy; BRCA cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg12310025 chr6:25882481 NA 0.72 18.12 0.58 1.55e-59 Blood metabolite levels; BRCA cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg17724175 chr1:150552817 MCL1 0.24 7.85 0.3 1.73e-14 Melanoma; BRCA trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg25214090 chr10:38739885 LOC399744 0.54 12.27 0.44 3.29e-31 Corneal astigmatism; BRCA cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.51e-23 Motion sickness; BRCA cis rs35110281 0.805 rs2838319 chr21:44991901 A/G cg01579765 chr21:45077557 HSF2BP -0.42 -11.42 -0.41 1.3e-27 Mean corpuscular volume; BRCA cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.4 -0.35 9.32e-20 Tonsillectomy; BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg08280861 chr8:58055591 NA 0.53 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs9986765 0.609 rs73452600 chr7:142828104 C/A cg21852589 chr7:142981689 TMEM139 0.61 10.07 0.37 2.97e-22 Cancer;Dermatomyositis; BRCA trans rs6582630 0.519 rs12578283 chr12:38325349 A/T cg06521331 chr12:34319734 NA -0.47 -8.69 -0.33 3.12e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2404602 0.716 rs17362383 chr15:76650702 A/G cg23625390 chr15:77176239 SCAPER 0.38 8.86 0.33 7.88e-18 Blood metabolite levels; BRCA cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg26677194 chr12:130822605 PIWIL1 0.6 14.33 0.49 1.31e-40 Menopause (age at onset); BRCA cis rs76419734 0.510 rs12504088 chr4:106662004 A/G cg24545054 chr4:106630052 GSTCD;INTS12 0.57 12.52 0.44 2.65e-32 Post bronchodilator FEV1; BRCA cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg24562669 chr7:97807699 LMTK2 0.45 11.86 0.42 1.82e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088580 0.634 rs6059866 chr20:33075810 A/C cg06115741 chr20:33292138 TP53INP2 0.36 8.12 0.31 2.47e-15 Glomerular filtration rate (creatinine); BRCA cis rs586533 0.881 rs10893643 chr11:99512107 C/G cg22878054 chr11:99397252 CNTN5 0.31 7.84 0.3 1.85e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs4925386 1.000 rs4925386 chr20:60921044 C/T cg24112000 chr20:60950667 NA -0.54 -11.87 -0.42 1.73e-29 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.69 0.39 1.17e-24 Cognitive ability; BRCA cis rs7301016 0.846 rs73124315 chr12:62970437 C/T cg01804193 chr12:63026212 NA 0.47 8.56 0.32 8.12e-17 IgG glycosylation; BRCA trans rs17685 0.672 rs1639618 chr7:75701987 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 28.25 0.75 1.44e-114 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs2204008 0.682 rs2320517 chr12:38259239 A/T cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs796364 0.806 rs203767 chr2:200902411 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs2842992 0.830 rs2758312 chr6:160153452 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.68 17.54 0.57 1.57e-56 Age-related macular degeneration (geographic atrophy); BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg04025307 chr7:1156635 C7orf50 0.56 10.58 0.39 3.28e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.94e-30 Tonsillectomy; BRCA cis rs12210905 0.688 rs12213471 chr6:27406063 C/G cg08851530 chr6:28072375 NA 0.81 7.89 0.3 1.3e-14 Hip circumference adjusted for BMI; BRCA cis rs73086581 1.000 rs73086535 chr20:3944150 T/C cg02187196 chr20:3869020 PANK2 0.53 9.55 0.35 2.71e-20 Response to antidepressants in depression; BRCA cis rs11098499 0.913 rs11098496 chr4:120167466 C/G cg09307838 chr4:120376055 NA 0.61 12.35 0.44 1.42e-31 Corneal astigmatism; BRCA cis rs5751614 0.557 rs5759666 chr22:23602342 C/T cg25410636 chr22:23605411 BCR -0.35 -8.02 -0.3 5.2e-15 Height; BRCA cis rs9787249 0.957 rs12086750 chr1:40210468 G/C cg24920358 chr1:40204285 PPIE 0.34 7.91 0.3 1.12e-14 Blood protein levels; BRCA cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg20891283 chr12:69753455 YEATS4 0.72 21.14 0.64 1.26e-75 Blood protein levels; BRCA cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs7149337 0.805 rs2999354 chr14:51607179 C/G cg23942311 chr14:51606299 NA 0.45 13.31 0.47 7.73e-36 Cancer; BRCA trans rs7980799 0.682 rs1580396 chr12:33615841 C/A cg26384229 chr12:38710491 ALG10B -0.49 -10.61 -0.39 2.49e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.23e-22 Bladder cancer; BRCA cis rs4900538 0.963 rs1190554 chr14:102918686 T/C cg18135206 chr14:102964638 TECPR2 0.99 26.78 0.73 1.65e-106 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9462846 0.802 rs1819324 chr6:42859723 G/C cg02353165 chr6:42928485 GNMT 0.44 8.29 0.31 6.67e-16 Blood protein levels; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg18402987 chr7:1209562 NA 0.44 8.66 0.32 3.86e-17 Longevity;Endometriosis; BRCA cis rs6745190 0.512 rs35482602 chr2:181995321 T/C cg00481216 chr2:181971175 NA 0.46 8.75 0.33 1.89e-17 White blood cell count; BRCA cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg11189052 chr15:85197271 WDR73 -0.43 -10.17 -0.37 1.3e-22 P wave terminal force; BRCA cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.15 0.49 9.38e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4908760 0.832 rs11121209 chr1:8686862 G/A cg20416874 chr1:8611966 RERE -0.28 -8.09 -0.3 3.08e-15 Vitiligo; BRCA cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.45 0.41 9.53e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6964587 0.843 rs56075286 chr7:91731518 G/A cg17063962 chr7:91808500 NA 0.58 13.56 0.47 5.22e-37 Breast cancer; BRCA cis rs5771069 0.896 rs137862 chr22:50446550 C/A cg27068297 chr22:50451975 IL17REL 0.33 7.92 0.3 1.02e-14 Ulcerative colitis; BRCA cis rs3857067 0.806 rs17374832 chr4:95114394 G/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg26384229 chr12:38710491 ALG10B 0.58 13.28 0.47 1.05e-35 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -9.82 -0.36 2.77e-21 Schizophrenia; BRCA cis rs10463316 0.894 rs6880137 chr5:150755232 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -8.09 -0.3 2.99e-15 Metabolite levels (Pyroglutamine); BRCA cis rs832540 0.669 rs832539 chr5:56199386 A/C cg22800045 chr5:56110881 MAP3K1 0.42 8.61 0.32 5.71e-17 Coronary artery disease; BRCA cis rs758324 0.947 rs1846650 chr5:131158767 C/T cg06307176 chr5:131281290 NA 0.53 10.19 0.37 1.08e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs826838 1.000 rs11168218 chr12:38884466 A/G cg13010199 chr12:38710504 ALG10B 0.55 12.08 0.43 2.07e-30 Heart rate; BRCA cis rs4268898 0.697 rs6714652 chr2:24383059 C/T cg06627628 chr2:24431161 ITSN2 0.42 8.61 0.32 5.5e-17 Asthma; BRCA cis rs875971 0.660 rs801190 chr7:66033033 C/T cg18876405 chr7:65276391 NA -0.62 -15.43 -0.52 6.52e-46 Aortic root size; BRCA cis rs7249142 0.512 rs12981160 chr19:19298099 T/A cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.48 -10.47 -0.38 8.64e-24 IgG glycosylation; BRCA cis rs1003719 0.762 rs1155786 chr21:38448025 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.07 0.49 2.19e-39 Eye color traits; BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.94e-30 Tonsillectomy; BRCA cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg00071950 chr4:10020882 SLC2A9 -0.43 -9.93 -0.37 1.02e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs67311347 0.866 rs2371183 chr3:40334247 C/T cg09455208 chr3:40491958 NA -0.34 -8.22 -0.31 1.11e-15 Renal cell carcinoma; BRCA cis rs765787 0.530 rs4442750 chr15:45535328 G/T cg15395560 chr15:45543142 SLC28A2 0.29 8.17 0.31 1.67e-15 Uric acid levels; BRCA cis rs67460515 0.563 rs34630898 chr3:160827038 A/G cg03342759 chr3:160939853 NMD3 -0.69 -14.11 -0.49 1.53e-39 Parkinson's disease; BRCA cis rs7666738 0.606 rs3846447 chr4:99099907 G/A cg05340658 chr4:99064831 C4orf37 0.47 10.28 0.38 4.96e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg08822215 chr16:89438651 ANKRD11 -0.41 -8.69 -0.33 3e-17 Multiple myeloma (IgH translocation); BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.98 -0.3 6.61e-15 Total body bone mineral density; BRCA cis rs651907 1.000 rs662792 chr3:101599608 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.35 8.26 0.31 8.26e-16 Colorectal cancer; BRCA cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.48 0.41 7.43e-28 Coronary artery disease; BRCA trans rs9944715 1.000 rs9963153 chr18:43840064 A/G cg01718231 chr17:29326311 RNF135 -0.47 -9.26 -0.34 3.06e-19 Red cell distribution width;Mean corpuscular volume; BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.65 11.84 0.42 2.14e-29 Gut microbiome composition (summer); BRCA cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg26031613 chr14:104095156 KLC1 0.74 16.39 0.54 1.21e-50 Body mass index; BRCA cis rs9287719 0.839 rs11683335 chr2:10756665 C/G cg00105475 chr2:10696890 NA 0.44 10.33 0.38 3.07e-23 Prostate cancer; BRCA trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg03929089 chr4:120376271 NA 0.6 10.17 0.37 1.26e-22 Acute lymphoblastic leukemia (childhood); BRCA cis rs9810890 1.000 rs73198827 chr3:128489521 G/T cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs6546550 0.901 rs11893500 chr2:70154187 T/C cg02498382 chr2:70120550 SNRNP27 -0.52 -11.34 -0.41 2.86e-27 Prevalent atrial fibrillation; BRCA cis rs2599510 0.811 rs176410 chr2:32643437 C/G cg02381751 chr2:32503542 YIPF4 -0.41 -8.19 -0.31 1.45e-15 Interleukin-18 levels; BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg04709771 chr16:646395 RAB40C 0.43 10.63 0.39 2.06e-24 Height; BRCA cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg08601574 chr20:25228251 PYGB -0.34 -8.18 -0.31 1.53e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 0.752 rs11211145 chr1:46108491 A/C cg06784218 chr1:46089804 CCDC17 0.52 12.54 0.44 2.12e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6430585 0.528 rs309152 chr2:136657252 C/T cg07169764 chr2:136633963 MCM6 -0.96 -19.3 -0.61 1e-65 Corneal structure; BRCA cis rs73086581 1.000 rs2326289 chr20:3952300 T/C cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs17253792 0.822 rs10147431 chr14:56091841 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg13770153 chr20:60521292 NA -0.44 -9.76 -0.36 4.63e-21 Body mass index; BRCA cis rs911555 0.755 rs975892 chr14:103883349 A/T cg12935359 chr14:103987150 CKB -0.63 -14.82 -0.51 6.19e-43 Intelligence (multi-trait analysis); BRCA cis rs2421770 0.504 rs7943314 chr11:35363823 A/G cg13971030 chr11:35366721 SLC1A2 -0.44 -9.76 -0.36 4.64e-21 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg09998033 chr7:158218633 PTPRN2 0.37 8.71 0.33 2.57e-17 Obesity-related traits; BRCA cis rs2072499 0.722 rs61462713 chr1:156161682 C/T cg25208724 chr1:156163844 SLC25A44 0.89 18.06 0.58 3.34e-59 Testicular germ cell tumor; BRCA cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg02297831 chr4:17616191 MED28 0.36 8.41 0.32 2.72e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10924970 0.904 rs10924500 chr1:235351436 T/G cg26050004 chr1:235667680 B3GALNT2 0.34 8.51 0.32 1.22e-16 Asthma; BRCA cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg05340658 chr4:99064831 C4orf37 0.64 14.92 0.51 2.01e-43 Colonoscopy-negative controls vs population controls; BRCA trans rs6598955 0.585 rs11577098 chr1:26602525 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs7178424 1.000 rs731820 chr15:62378136 G/A cg00456672 chr15:62358751 C2CD4A -0.35 -8.29 -0.31 6.74e-16 Height; BRCA cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg11663144 chr21:46675770 NA -0.57 -13.28 -0.47 1.03e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17376456 0.877 rs28637444 chr5:93495548 C/T cg21475434 chr5:93447410 FAM172A 0.72 9.01 0.34 2.28e-18 Diabetic retinopathy; BRCA cis rs367943 0.933 rs451453 chr5:112808970 G/C cg12552261 chr5:112820674 MCC -0.55 -12.22 -0.44 4.98e-31 Type 2 diabetes; BRCA cis rs11098499 0.722 rs10025925 chr4:120271744 A/T cg09307838 chr4:120376055 NA 0.6 13.04 0.46 1.3e-34 Corneal astigmatism; BRCA cis rs3806843 1.000 rs13157397 chr5:140184442 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.79 -0.36 3.63e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs2180341 0.960 rs9401952 chr6:127677027 A/C cg24812749 chr6:127587940 RNF146 0.85 19.76 0.62 3.28e-68 Breast cancer; BRCA cis rs12497850 0.931 rs4974085 chr3:48924900 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.63 0.36 1.33e-20 Parkinson's disease; BRCA cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg18132916 chr6:79620363 NA -0.46 -10.34 -0.38 2.93e-23 Intelligence (multi-trait analysis); BRCA cis rs9308433 0.529 rs4655243 chr1:214497291 A/G cg06198575 chr1:214491504 SMYD2 0.56 12.24 0.44 4.43e-31 IgG glycosylation; BRCA trans rs11098499 0.908 rs28499576 chr4:120386677 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.75 0.45 2.35e-33 Corneal astigmatism; BRCA cis rs4481887 0.772 rs4916127 chr1:248466615 A/G cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.79e-18 Common traits (Other); BRCA cis rs11723261 0.582 rs4634177 chr4:136837 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.34 7.9 0.3 1.2e-14 Immune response to smallpox vaccine (IL-6); BRCA cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA cis rs12973672 0.904 rs12974791 chr19:35767218 A/G cg12095397 chr19:35769544 USF2 0.37 8.37 0.31 3.71e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.33 -8.63 -0.32 4.74e-17 Total body bone mineral density; BRCA cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg02734326 chr4:10020555 SLC2A9 0.39 8.48 0.32 1.61e-16 Bone mineral density; BRCA cis rs7646881 0.812 rs73017541 chr3:158460796 T/G cg19483011 chr3:158453295 NA -0.47 -8.04 -0.3 4.27e-15 Tetralogy of Fallot; BRCA cis rs11718455 0.960 rs11720974 chr3:43999111 G/C cg08738300 chr3:44038990 NA 0.44 8.56 0.32 8.69e-17 Coronary artery disease; BRCA cis rs8180040 0.966 rs7649234 chr3:47494380 G/C cg16586182 chr3:47516702 SCAP -0.63 -14.74 -0.5 1.49e-42 Colorectal cancer; BRCA cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg08859206 chr1:53392774 SCP2 -0.44 -8.91 -0.33 5.37e-18 Monocyte count; BRCA cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg16405210 chr4:1374714 KIAA1530 -0.47 -10.59 -0.39 2.97e-24 Longevity; BRCA cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg03452623 chr4:187889614 NA 0.34 10.9 0.4 1.7e-25 Lobe attachment (rater-scored or self-reported); BRCA trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21659725 chr3:3221576 CRBN -0.69 -20.84 -0.64 5.71e-74 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.721 rs10890337 chr1:46124527 C/T cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1801251 1.000 rs283477 chr2:233649427 A/G cg08000102 chr2:233561755 GIGYF2 0.61 12.9 0.45 5.1e-34 Coronary artery disease; BRCA cis rs9469578 1.000 rs16869456 chr6:33714622 G/A cg18708504 chr6:33715942 IP6K3 0.7 10.19 0.37 1.09e-22 Phosphorus levels; BRCA cis rs17401966 0.540 rs3748581 chr1:10441664 T/C cg03954927 chr1:10346856 KIF1B 0.34 10.24 0.38 7.1e-23 Hepatocellular carcinoma; BRCA cis rs12714314 0.914 rs12986730 chr2:1959401 G/A cg22511877 chr2:1942942 MYT1L 0.38 8.09 0.3 2.93e-15 Type 2 diabetes (age of onset); BRCA trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg27661571 chr11:113659931 NA -0.7 -10.88 -0.4 2e-25 Hip circumference adjusted for BMI; BRCA cis rs11971779 0.715 rs10954646 chr7:139061069 C/G cg07862535 chr7:139043722 LUC7L2 -0.37 -10.12 -0.37 1.96e-22 Diisocyanate-induced asthma; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg09436375 chr6:42928200 GNMT -0.29 -10.37 -0.38 2.15e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.862 rs801206 chr7:66021966 C/G cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA cis rs72772090 0.710 rs11750400 chr5:96077968 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.76 -0.45 2.16e-33 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg25036284 chr2:26402008 FAM59B -0.89 -15.63 -0.53 7.3e-47 Gut microbiome composition (summer); BRCA cis rs813218 0.523 rs497868 chr3:99450187 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -9.33 -0.35 1.68e-19 Orofacial clefts; BRCA cis rs7833986 0.501 rs72653951 chr8:56961837 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.64 12.43 0.44 6.54e-32 Height; BRCA cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg26395211 chr5:140044315 WDR55 0.38 8.67 0.32 3.64e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs1355223 0.552 rs2421743 chr11:34882840 C/T cg11058730 chr11:34937778 PDHX;APIP 0.71 16.86 0.55 4.78e-53 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs908922 0.636 rs474086 chr1:152513431 C/T cg20991723 chr1:152506922 NA 0.39 8.9 0.33 5.57e-18 Hair morphology; BRCA cis rs11603020 0.950 rs28362949 chr11:57371911 G/T cg19752551 chr11:57585705 CTNND1 -0.43 -9.96 -0.37 7.8e-22 Blood protein levels; BRCA cis rs1008375 0.966 rs11737844 chr4:17697421 A/C cg16339924 chr4:17578868 LAP3 0.58 14.2 0.49 5.37e-40 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9309473 0.519 rs7606947 chr2:73909818 C/T cg20560298 chr2:73613845 ALMS1 -0.38 -9.87 -0.36 1.74e-21 Metabolite levels; BRCA cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg13852791 chr20:30311386 BCL2L1 -0.86 -16.75 -0.55 1.82e-52 Mean corpuscular hemoglobin; BRCA cis rs10911232 0.507 rs10911199 chr1:182998036 T/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.91 -0.3 1.14e-14 Corneal astigmatism; BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.64 10.26 0.38 5.86e-23 Renal function-related traits (BUN); BRCA cis rs9612 0.718 rs346531 chr19:44239927 T/C cg08581076 chr19:44259116 C19orf61 0.44 7.9 0.3 1.23e-14 Exhaled nitric oxide output; BRCA cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg04455712 chr21:45112962 RRP1B 0.46 11.34 0.41 2.85e-27 Mean corpuscular volume; BRCA cis rs7095944 0.614 rs7898003 chr10:126451385 G/A cg08799069 chr10:126477246 METTL10 -0.4 -10.16 -0.37 1.43e-22 Asthma; BRCA cis rs7103648 0.897 rs2278890 chr11:47399602 G/A cg20307385 chr11:47447363 PSMC3 0.83 20.74 0.63 1.94e-73 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg00074818 chr8:8560427 CLDN23 0.38 8.37 0.31 3.69e-16 Obesity-related traits; BRCA cis rs6942756 1.000 rs7803052 chr7:128959427 A/G cg02491457 chr7:128862824 NA -0.71 -14.03 -0.49 3.61e-39 White matter hyperintensity burden; BRCA cis rs7617773 0.780 rs11718350 chr3:48360992 T/G cg11946769 chr3:48343235 NME6 0.7 14.01 0.48 4.45e-39 Coronary artery disease; BRCA cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.38 -8.68 -0.32 3.36e-17 Alzheimer's disease (late onset); BRCA cis rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05901451 chr6:126070800 HEY2 0.39 9.66 0.36 1.04e-20 Endometrial cancer; BRCA cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg25358565 chr5:93447407 FAM172A 1.15 17.96 0.58 1.13e-58 Diabetic retinopathy; BRCA cis rs11605924 1.000 rs11605924 chr11:45873091 A/C ch.11.939596F chr11:45881766 CRY2 -0.47 -10.27 -0.38 5.22e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2762353 0.935 rs1165215 chr6:25798932 G/A cg03264133 chr6:25882463 NA -0.48 -10.77 -0.39 5.48e-25 Blood metabolite levels; BRCA cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg07507251 chr3:52567010 NT5DC2 0.35 7.9 0.3 1.19e-14 Electroencephalogram traits; BRCA cis rs7666738 0.830 rs4699590 chr4:98974030 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg22800045 chr5:56110881 MAP3K1 0.61 11.5 0.41 6.04e-28 Initial pursuit acceleration; BRCA cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3008870 1.000 rs11208976 chr1:67434411 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg04607235 chr12:12878440 APOLD1 -0.66 -10.2 -0.37 9.65e-23 Systemic lupus erythematosus; BRCA cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg20503657 chr10:835505 NA 1.33 22.01 0.66 2.37e-80 Eosinophil percentage of granulocytes; BRCA cis rs1048238 0.525 rs848214 chr1:16265422 A/G cg21385522 chr1:16154831 NA -0.47 -9.98 -0.37 6.85e-22 Systolic blood pressure; BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg25036284 chr2:26402008 FAM59B -0.63 -10.54 -0.38 4.8e-24 Gut microbiome composition (summer); BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA cis rs2073300 1.000 rs6132625 chr20:23444671 C/T cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7246657 0.943 rs7252099 chr19:37933780 G/A cg23950597 chr19:37808831 NA -0.74 -13.06 -0.46 1.05e-34 Coronary artery calcification; BRCA cis rs1468333 0.897 rs6888877 chr5:137510357 T/C cg27119451 chr5:137514611 BRD8;KIF20A -0.44 -8.53 -0.32 1.05e-16 Resting heart rate; BRCA cis rs1797081 0.561 rs2603795 chr10:16860256 A/G cg14835575 chr10:16859367 RSU1 0.34 8.88 0.33 6.58e-18 Platelet distribution width; BRCA cis rs6714710 0.603 rs11681535 chr2:98488949 G/C cg26665480 chr2:98280029 ACTR1B 0.58 13.56 0.47 5.34e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg14844989 chr11:31128820 NA -0.44 -9.51 -0.35 3.92e-20 Red blood cell count; BRCA cis rs7246657 0.722 rs1531549 chr19:38088009 T/C cg23950597 chr19:37808831 NA -0.51 -8.72 -0.33 2.31e-17 Coronary artery calcification; BRCA cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg08917208 chr2:24149416 ATAD2B 0.6 9.36 0.35 1.32e-19 Lymphocyte counts; BRCA cis rs4766646 0.619 rs9645838 chr12:110291572 A/G cg01252219 chr12:110302105 GLTP 0.36 7.96 0.3 7.8e-15 Metabolite levels (MHPG); BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.05 0.43 2.68e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2197308 0.667 rs11181073 chr12:37898543 A/G cg06521331 chr12:34319734 NA -0.54 -10.23 -0.38 7.72e-23 Morning vs. evening chronotype; BRCA cis rs7100689 0.784 rs7895042 chr10:82095276 G/A cg01528321 chr10:82214614 TSPAN14 0.91 19.91 0.62 5.24e-69 Post bronchodilator FEV1; BRCA cis rs9381107 0.505 rs9369420 chr6:9486467 A/G cg14735645 chr6:9486422 NA 0.44 8.81 0.33 1.16e-17 Nonsyndromic cleft lip with cleft palate; BRCA cis rs6598955 0.671 rs75517917 chr1:26612926 G/T cg04990556 chr1:26633338 UBXN11 0.56 8.58 0.32 7.03e-17 Obesity-related traits; BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -18.3 -0.59 1.84e-60 Initial pursuit acceleration; BRCA cis rs1215050 0.791 rs783960 chr4:98893437 A/G cg05340658 chr4:99064831 C4orf37 -0.44 -10.18 -0.37 1.21e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11887277 0.868 rs6717682 chr2:27069211 A/G cg12368169 chr2:27073192 DPYSL5 -0.33 -10.03 -0.37 4.4e-22 Obesity-related traits; BRCA cis rs763121 0.962 rs138703 chr22:39132748 C/T cg06544989 chr22:39130855 UNC84B 0.38 9.55 0.35 2.7e-20 Menopause (age at onset); BRCA cis rs7677751 0.806 rs61320297 chr4:55088175 G/A cg17187183 chr4:55093834 PDGFRA 0.44 9.14 0.34 7.9e-19 Corneal astigmatism; BRCA cis rs11971779 0.584 rs6962029 chr7:139034719 T/C cg07862535 chr7:139043722 LUC7L2 0.39 10.46 0.38 9.65e-24 Diisocyanate-induced asthma; BRCA cis rs36051895 0.632 rs10217652 chr9:5119939 A/G cg02405213 chr9:5042618 JAK2 -0.48 -9.42 -0.35 8.12e-20 Pediatric autoimmune diseases; BRCA cis rs7617773 0.780 rs2541 chr3:48339618 A/G cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg06636001 chr8:8085503 FLJ10661 -0.54 -12.02 -0.43 3.84e-30 Mood instability; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26314531 chr2:26401878 FAM59B 0.95 16.42 0.54 8.01e-51 Gut microbiome composition (summer); BRCA cis rs6940638 0.688 rs7764984 chr6:27034181 A/G cg12826209 chr6:26865740 GUSBL1 0.44 9.18 0.34 5.95e-19 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.595 rs6907924 chr6:26438817 T/G cg09904177 chr6:26538194 HMGN4 -0.37 -9.8 -0.36 3.34e-21 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.64 13.16 0.46 3.68e-35 Lymphocyte counts; BRCA cis rs4363385 0.747 rs7521181 chr1:152955223 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.72 -0.33 2.34e-17 Inflammatory skin disease; BRCA cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg15212455 chr7:39170539 POU6F2 0.43 9.54 0.35 2.9e-20 IgG glycosylation; BRCA cis rs2991971 0.934 rs11580609 chr1:45975856 C/G cg15605315 chr1:45957053 TESK2 0.49 10.07 0.37 3.02e-22 High light scatter reticulocyte count; BRCA trans rs7615952 0.599 rs2333408 chr3:125732098 G/A cg07211511 chr3:129823064 LOC729375 -0.57 -10.82 -0.39 3.52e-25 Blood pressure (smoking interaction); BRCA cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.69 0.33 3.02e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4664304 0.620 rs2048437 chr2:160712065 C/T cg02280532 chr2:160761244 LY75 0.35 7.85 0.3 1.81e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2032447 0.714 rs129129 chr6:25961029 A/G cg03517284 chr6:25882590 NA -0.45 -9.64 -0.36 1.22e-20 Intelligence (multi-trait analysis); BRCA cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg06917634 chr15:78832804 PSMA4 -0.76 -17.72 -0.57 1.79e-57 Sudden cardiac arrest; BRCA trans rs6479891 0.908 rs61853639 chr10:65305113 G/T cg14819942 chr15:35414228 NA 0.35 8.48 0.32 1.58e-16 Arthritis (juvenile idiopathic); BRCA cis rs829883 0.573 rs73136486 chr12:98913727 T/A cg25150519 chr12:98850993 NA -0.52 -9.48 -0.35 4.95e-20 Colorectal adenoma (advanced); BRCA cis rs1003719 0.591 rs2040125 chr21:38549236 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.53 11.5 0.41 6.13e-28 Eye color traits; BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -11.61 -0.42 2.03e-28 Tonsillectomy; BRCA cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.16 -0.31 1.79e-15 Extrinsic epigenetic age acceleration; BRCA cis rs881375 0.967 rs1930780 chr9:123686219 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.96 0.4 1.03e-25 Rheumatoid arthritis; BRCA cis rs12618769 0.597 rs3754883 chr2:99129451 T/C cg10123293 chr2:99228465 UNC50 0.41 8.22 0.31 1.1e-15 Bipolar disorder; BRCA cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg18876405 chr7:65276391 NA 0.54 12.92 0.45 4.49e-34 Aortic root size; BRCA cis rs13046373 0.507 rs8133828 chr21:32033046 C/G cg06468780 chr21:31798236 KRTAP13-3 0.36 8.59 0.32 6.86e-17 HDL cholesterol; BRCA cis rs41005 1.000 rs34505904 chr2:8115159 T/C cg03155496 chr2:8117019 LOC339788 -0.58 -15.78 -0.53 1.34e-47 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs10876993 1.000 rs10876993 chr12:58062667 C/T cg18357645 chr12:58087776 OS9 0.45 13.14 0.46 4.29e-35 Celiac disease or Rheumatoid arthritis; BRCA cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.49 0.47 1.16e-36 Colorectal cancer; BRCA cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg25019033 chr10:957182 NA -0.41 -7.88 -0.3 1.41e-14 Eosinophil percentage of granulocytes; BRCA cis rs10838687 0.673 rs59567949 chr11:47300155 G/A cg25783544 chr11:47291846 MADD 0.41 7.88 0.3 1.43e-14 Proinsulin levels; BRCA cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg13944838 chr5:179740914 GFPT2 -0.71 -15.13 -0.51 1.96e-44 Height; BRCA cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg13010199 chr12:38710504 ALG10B 0.54 11.87 0.43 1.61e-29 Heart rate; BRCA cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg06784218 chr1:46089804 CCDC17 0.45 10.76 0.39 6.28e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1403694 0.695 rs3774291 chr3:186433471 C/T cg12454167 chr3:186435060 KNG1 0.29 7.91 0.3 1.17e-14 Blood protein levels; BRCA trans rs12458462 0.892 rs35928863 chr18:77438956 A/G cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.45 -8.56 -0.32 8.18e-17 Monocyte count; BRCA cis rs6138458 0.887 rs227622 chr20:24910597 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.76 0.7 2.17e-95 Blood protein levels; BRCA trans rs17685 0.753 rs6951943 chr7:75772452 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 27.26 0.73 3.84e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg12386194 chr3:101231763 SENP7 0.46 9.84 0.36 2.3e-21 Colorectal cancer; BRCA cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14442939 chr10:27389572 ANKRD26 0.66 10.92 0.4 1.5e-25 Breast cancer; BRCA cis rs838147 0.537 rs504963 chr19:49208865 G/A cg07051648 chr19:49177693 NTN5;SEC1 -0.43 -8.05 -0.3 4.03e-15 Dietary macronutrient intake; BRCA cis rs1975991 0.711 rs1871521 chr3:187966035 G/A cg15417654 chr3:187959138 LPP 0.34 8.73 0.33 2.23e-17 White matter integrity (bipolar disorder risk interaction); BRCA cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg18305652 chr10:134549665 INPP5A 0.48 11.9 0.43 1.28e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg13628971 chr7:2884303 GNA12 0.38 8.32 0.31 5.38e-16 Height; BRCA cis rs9341808 0.718 rs9352806 chr6:80980057 G/T cg08355045 chr6:80787529 NA 0.4 10.86 0.39 2.47e-25 Sitting height ratio; BRCA cis rs6831352 0.760 rs1311616 chr4:100012303 T/G cg12011299 chr4:100065546 ADH4 0.48 10.94 0.4 1.21e-25 Alcohol dependence; BRCA cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.55 11.2 0.41 1.05e-26 Multiple sclerosis; BRCA cis rs9462027 0.628 rs3734268 chr6:34716028 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 8.03e-15 Systemic lupus erythematosus; BRCA cis rs2836974 0.604 rs2854727 chr21:40713787 A/G cg11644478 chr21:40555479 PSMG1 0.55 11.76 0.42 4.99e-29 Cognitive function; BRCA cis rs11098499 0.909 rs28714195 chr4:120316950 A/T cg09307838 chr4:120376055 NA 0.75 16.86 0.55 5.11e-53 Corneal astigmatism; BRCA cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.72 12.04 0.43 3.21e-30 Schizophrenia; BRCA cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg11952622 chr19:58962976 ZNF324B 0.4 8.35 0.31 4.38e-16 Uric acid clearance; BRCA cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg22974920 chr21:40686053 BRWD1 -0.4 -8.7 -0.33 2.76e-17 Cognitive function; BRCA trans rs7939886 0.920 rs77391761 chr11:55814896 G/C cg15704280 chr7:45808275 SEPT13 0.62 7.92 0.3 1.07e-14 Myopia (pathological); BRCA cis rs35740288 1.000 rs17577449 chr15:86297185 G/A cg20737812 chr15:86336631 KLHL25 -0.33 -8.82 -0.33 1.07e-17 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs611744 0.647 rs647907 chr8:109251374 T/C cg21045802 chr8:109455806 TTC35 0.35 7.96 0.3 8.09e-15 Dupuytren's disease; BRCA cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg26031613 chr14:104095156 KLC1 -0.54 -9.58 -0.35 2.07e-20 Reticulocyte count; BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg03709012 chr19:19516395 GATAD2A 0.8 18.72 0.6 1.09e-62 Tonsillectomy; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg22907277 chr7:1156413 C7orf50 0.5 10.87 0.4 2.23e-25 Longevity;Endometriosis; BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 11.35 0.41 2.52e-27 Platelet count; BRCA cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.23 0.41 7.82e-27 Bipolar disorder; BRCA cis rs6582630 0.519 rs8189618 chr12:38276281 A/C cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.88e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs2304069 0.954 rs4705409 chr5:149414899 A/G cg12661370 chr5:149340060 SLC26A2 0.51 7.85 0.3 1.76e-14 HIV-1 control; BRCA cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg26587870 chr6:27730563 NA -0.4 -8.59 -0.32 6.61e-17 Parkinson's disease; BRCA cis rs17253792 0.732 rs28380739 chr14:56088402 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.26 -0.38 5.65e-23 Putamen volume; BRCA cis rs8062405 0.755 rs62034325 chr16:28538640 A/G cg16576597 chr16:28551801 NUPR1 0.35 9.48 0.35 5.09e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs67460515 0.563 rs11720263 chr3:160848293 T/C cg03342759 chr3:160939853 NMD3 -0.72 -14.8 -0.51 8.05e-43 Parkinson's disease; BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg13880726 chr7:1868755 MAD1L1 0.52 10.29 0.38 4.55e-23 Bipolar disorder and schizophrenia; BRCA cis rs4664304 0.620 rs1397717 chr2:160720444 G/T cg18514922 chr2:160761262 LY75 0.33 7.89 0.3 1.29e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs858239 0.601 rs11982002 chr7:23163270 C/T cg23682824 chr7:23144976 KLHL7 0.42 11.0 0.4 6.55e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg27489772 chr12:121021490 NA 0.43 7.91 0.3 1.1e-14 Type 1 diabetes nephropathy; BRCA trans rs561341 0.941 rs550213 chr17:30317518 C/G cg27661571 chr11:113659931 NA -0.5 -8.56 -0.32 8.43e-17 Hip circumference adjusted for BMI; BRCA trans rs12517041 1.000 rs6879795 chr5:23305275 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.48 -8.6 -0.32 6.01e-17 Calcium levels; BRCA cis rs13118159 0.742 rs34947293 chr4:1335034 T/C cg05025164 chr4:1340916 KIAA1530 0.42 9.34 0.35 1.61e-19 Longevity; BRCA cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg12365402 chr11:9010492 NRIP3 0.43 9.62 0.36 1.55e-20 Hemoglobin concentration; BRCA cis rs9640161 0.742 rs2108853 chr7:150017589 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.53 -13.23 -0.46 1.68e-35 Blood protein levels;Circulating chemerin levels; BRCA cis rs7246657 0.943 rs10426666 chr19:37828514 C/G cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA cis rs1371614 0.635 rs10175737 chr2:27139747 C/A cg12368169 chr2:27073192 DPYSL5 -0.29 -8.73 -0.33 2.13e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.53e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs13064411 0.696 rs1386336 chr3:113144153 C/T cg18753928 chr3:113234510 CCDC52 -0.5 -9.36 -0.35 1.39e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs8010715 0.816 rs762093 chr14:24591918 G/C cg23112188 chr14:24563095 PCK2 -0.32 -8.04 -0.3 4.44e-15 IgG glycosylation; BRCA trans rs11039798 0.614 rs8188910 chr11:48825740 C/T cg15704280 chr7:45808275 SEPT13 0.6 8.89 0.33 6.33e-18 Axial length; BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg04352962 chr1:209979756 IRF6 0.47 11.85 0.42 2.08e-29 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg02675527 chr2:114030824 PAX8;LOC440839 -0.43 -10.03 -0.37 4.51e-22 Lymphocyte counts; BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA trans rs6582630 0.519 rs80226845 chr12:38528231 C/A cg06521331 chr12:34319734 NA -0.47 -8.79 -0.33 1.33e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs11997175 0.756 rs4739435 chr8:33818818 A/G ch.8.33884649F chr8:33765107 NA 0.41 10.05 0.37 3.76e-22 Body mass index; BRCA cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg11941060 chr3:133502564 NA -0.51 -12.24 -0.44 4.13e-31 Iron status biomarkers; BRCA trans rs6582630 0.519 rs10880576 chr12:38497693 T/C cg06521331 chr12:34319734 NA -0.45 -8.58 -0.32 7.02e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2180341 0.883 rs9388568 chr6:127690694 C/A cg24812749 chr6:127587940 RNF146 0.86 19.78 0.62 2.55e-68 Breast cancer; BRCA cis rs9560113 1.000 rs4773383 chr13:112177764 C/T cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.88e-14 Menarche (age at onset); BRCA trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg15556689 chr8:8085844 FLJ10661 -0.43 -12.11 -0.43 1.56e-30 Neuroticism; BRCA cis rs11191205 0.644 rs11191069 chr10:103388129 A/C cg15320455 chr10:103880129 LDB1 -0.46 -7.9 -0.3 1.25e-14 Intelligence (multi-trait analysis); BRCA trans rs1814175 0.645 rs10742953 chr11:49807491 C/G cg15704280 chr7:45808275 SEPT13 0.91 24.31 0.69 5.97e-93 Height; BRCA cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 3.1e-22 Bladder cancer; BRCA cis rs765787 0.530 rs1706835 chr15:45517884 G/A cg24006582 chr15:45444508 DUOX1 -0.55 -11.42 -0.41 1.3e-27 Uric acid levels; BRCA cis rs12477438 0.520 rs2969379 chr2:99776686 G/A cg08885076 chr2:99613938 TSGA10 0.43 10.22 0.37 8.29e-23 Chronic sinus infection; BRCA cis rs9393777 0.528 rs34843552 chr6:27241915 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.26 -8.11 -0.31 2.66e-15 Intelligence (multi-trait analysis); BRCA trans rs9291683 0.595 rs35501905 chr4:10053431 C/T cg26043149 chr18:55253948 FECH 0.47 9.85 0.36 2e-21 Bone mineral density; BRCA cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg00071950 chr4:10020882 SLC2A9 0.64 15.97 0.53 1.4e-48 Bone mineral density; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg05863683 chr7:1912471 MAD1L1 0.38 8.41 0.32 2.77e-16 Bipolar disorder and schizophrenia; BRCA cis rs72634258 0.554 rs17374781 chr1:7919363 A/G cg26816564 chr1:7831052 VAMP3 -0.53 -10.52 -0.38 5.68e-24 Inflammatory bowel disease; BRCA cis rs6964587 0.869 rs6975243 chr7:91514672 G/A cg17063962 chr7:91808500 NA -0.53 -12.03 -0.43 3.33e-30 Breast cancer; BRCA cis rs73086581 0.898 rs11906452 chr20:3981559 A/G cg02187196 chr20:3869020 PANK2 0.46 8.49 0.32 1.49e-16 Response to antidepressants in depression; BRCA cis rs9811920 0.535 rs793483 chr3:99489825 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.86 -0.36 1.97e-21 Axial length; BRCA cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg05147244 chr20:61493195 TCFL5 0.85 11.15 0.4 1.74e-26 Obesity-related traits; BRCA cis rs6120849 0.708 rs6087659 chr20:33606383 C/A cg24642439 chr20:33292090 TP53INP2 0.6 10.33 0.38 3.17e-23 Protein C levels; BRCA cis rs6964587 0.773 rs38793 chr7:92027187 A/G cg17063962 chr7:91808500 NA -0.53 -11.48 -0.41 7.25e-28 Breast cancer; BRCA cis rs13315871 1.000 rs11715445 chr3:58343888 T/C cg20936604 chr3:58311152 NA -0.65 -7.99 -0.3 6.38e-15 Cholesterol, total; BRCA cis rs9463078 0.809 rs6933553 chr6:45027770 T/C cg25276700 chr6:44698697 NA -0.36 -8.21 -0.31 1.19e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7039377 0.554 rs12351753 chr9:38673105 C/G cg14625731 chr9:38672608 NA -0.43 -9.42 -0.35 8.03e-20 Obesity-related traits; BRCA cis rs1030877 0.515 rs1020064 chr2:105897740 T/G cg02079111 chr2:105885981 TGFBRAP1 0.67 12.76 0.45 2.24e-33 Obesity-related traits; BRCA cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg13880726 chr7:1868755 MAD1L1 0.41 7.98 0.3 6.85e-15 Bipolar disorder and schizophrenia; BRCA cis rs795484 0.633 rs904662 chr12:118581833 C/T cg16572268 chr12:118583242 PEBP1 0.35 9.31 0.35 2.04e-19 Morphine dose requirement in tonsillectomy and adenoidectomy surgery; BRCA cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg23583168 chr7:148888333 NA -0.93 -23.61 -0.68 4.52e-89 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -13.29 -0.47 9.56e-36 Platelet count; BRCA trans rs3780486 0.846 rs10813954 chr9:33137596 A/C cg20290983 chr6:43655470 MRPS18A 1.11 40.57 0.85 5.58e-179 IgG glycosylation; BRCA trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg25482853 chr8:67687455 SGK3 0.97 15.32 0.52 2.31e-45 Lung disease severity in cystic fibrosis; BRCA cis rs36051895 0.659 rs67006981 chr9:5070401 A/G cg02405213 chr9:5042618 JAK2 -0.54 -9.71 -0.36 6.84e-21 Pediatric autoimmune diseases; BRCA cis rs7903847 0.642 rs10882908 chr10:99134970 T/C cg20016023 chr10:99160130 RRP12 -0.27 -8.67 -0.32 3.62e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2204008 0.689 rs1581357 chr12:38391479 C/G cg13010199 chr12:38710504 ALG10B 0.51 10.32 0.38 3.52e-23 Bladder cancer; BRCA cis rs7772486 0.846 rs2748499 chr6:146315002 T/C cg23711669 chr6:146136114 FBXO30 0.74 17.0 0.56 9.95e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs17376456 0.877 rs35747258 chr5:93310129 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.85 0.6 2.34e-63 Diabetic retinopathy; BRCA cis rs897080 0.552 rs1067323 chr2:44630018 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.37 0.35 1.23e-19 Height; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg20007245 chr22:24372913 LOC391322 -0.55 -12.26 -0.44 3.46e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs208520 0.770 rs2224422 chr6:66883993 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -18.36 -0.59 9.01e-61 Exhaled nitric oxide output; BRCA cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.08 0.4 3.31e-26 Bipolar disorder; BRCA trans rs2197308 0.659 rs11181327 chr12:37903171 C/T cg06521331 chr12:34319734 NA 0.46 8.92 0.33 4.79e-18 Morning vs. evening chronotype; BRCA cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 13.02 0.46 1.47e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7756236 0.521 rs6907437 chr6:36625021 A/G cg08179530 chr6:36648295 CDKN1A 0.38 8.22 0.31 1.1e-15 QRS duration; BRCA trans rs4714291 0.832 rs6917417 chr6:40104628 T/C cg02267698 chr19:7991119 CTXN1 -0.46 -9.63 -0.36 1.43e-20 Strep throat; BRCA cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg14993813 chr1:46806288 NSUN4 -0.47 -9.04 -0.34 1.91e-18 Menopause (age at onset); BRCA cis rs35306767 0.903 rs11253494 chr10:937047 C/T cg26597838 chr10:835615 NA 1.01 18.0 0.58 6.39e-59 Eosinophil percentage of granulocytes; BRCA trans rs10838798 0.504 rs10838852 chr11:48286256 C/T cg15704280 chr7:45808275 SEPT13 -0.42 -8.14 -0.31 2e-15 Height; BRCA cis rs2576037 0.796 rs2247021 chr18:44578794 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.4 -8.09 -0.3 3.03e-15 Personality dimensions; BRCA cis rs9457247 0.602 rs9459854 chr6:167465882 C/T cg07741184 chr6:167504864 NA 0.36 10.39 0.38 1.72e-23 Crohn's disease; BRCA cis rs10129255 0.500 rs12101190 chr14:107192386 C/T cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.69e-17 Kawasaki disease; BRCA cis rs9381040 0.655 rs2268194 chr6:41024447 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -9.05 -0.34 1.76e-18 Alzheimer's disease (late onset); BRCA cis rs7264396 0.790 rs6058290 chr20:34247702 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.39 8.31 0.31 5.95e-16 Total cholesterol levels; BRCA cis rs4713118 0.513 rs156734 chr6:28007357 A/C cg10876282 chr6:28092338 ZSCAN16 0.41 7.96 0.3 7.79e-15 Parkinson's disease; BRCA cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg06547715 chr2:218990976 CXCR2 0.32 8.04 0.3 4.49e-15 Ulcerative colitis; BRCA cis rs11191205 0.644 rs11191062 chr10:103366645 T/C cg15320455 chr10:103880129 LDB1 0.46 8.03 0.3 4.66e-15 Intelligence (multi-trait analysis); BRCA trans rs6952808 0.529 rs73038442 chr7:2139457 C/T cg04565464 chr8:145669602 NFKBIL2 0.44 9.87 0.36 1.69e-21 Bipolar disorder and schizophrenia; BRCA cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg19628046 chr18:33552617 C18orf21 0.55 10.51 0.38 6.33e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.58 -0.39 3.38e-24 Lymphocyte counts; BRCA cis rs6570726 0.738 rs7746330 chr6:145899257 A/C cg05347473 chr6:146136440 FBXO30 0.43 8.63 0.32 4.97e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs611744 0.647 rs589347 chr8:109253929 T/A cg21045802 chr8:109455806 TTC35 0.35 8.03 0.3 4.64e-15 Dupuytren's disease; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg09177884 chr7:1199841 ZFAND2A -0.59 -14.21 -0.49 4.97e-40 Longevity;Endometriosis; BRCA cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg26597838 chr10:835615 NA 1.0 15.64 0.53 6.72e-47 Eosinophil percentage of granulocytes; BRCA cis rs7766436 0.885 rs4712699 chr6:22592884 C/A cg13666174 chr6:22585274 NA -0.49 -11.49 -0.41 6.42e-28 Coronary artery disease; BRCA cis rs7975161 0.572 rs4614534 chr12:104597917 C/T cg25273343 chr12:104657179 TXNRD1 0.56 9.6 0.35 1.81e-20 Toenail selenium levels; BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -7.82 -0.3 2.13e-14 Developmental language disorder (linguistic errors); BRCA cis rs34779708 0.833 rs12777517 chr10:35473927 T/G cg03585969 chr10:35415529 CREM 0.55 11.44 0.41 1.09e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3008870 0.755 rs2815355 chr1:67485034 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.62 13.48 0.47 1.22e-36 Lymphocyte percentage of white cells; BRCA cis rs6942756 0.774 rs66479871 chr7:129009687 T/C cg02491457 chr7:128862824 NA -0.56 -11.83 -0.42 2.47e-29 White matter hyperintensity burden; BRCA cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg10932868 chr11:921992 NA 0.49 12.51 0.44 2.84e-32 Alzheimer's disease (late onset); BRCA cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg17971929 chr21:40555470 PSMG1 0.58 9.24 0.34 3.74e-19 Cognitive function; BRCA cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.69 17.97 0.58 9.11e-59 Age-related macular degeneration (geographic atrophy); BRCA cis rs7917772 0.503 rs11191326 chr10:104302959 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11105298 0.891 rs10858899 chr12:89923811 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.33 -0.35 1.65e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs17092148 1.000 rs6088579 chr20:33284624 A/G cg16810054 chr20:33298113 TP53INP2 -0.5 -10.82 -0.39 3.47e-25 Neuroticism; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg27588902 chr6:42928151 GNMT -0.31 -10.4 -0.38 1.7e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.93 0.33 4.51e-18 Motion sickness; BRCA trans rs208520 0.690 rs1304672 chr6:66847973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 18.25 0.59 3.4e-60 Exhaled nitric oxide output; BRCA cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg21573476 chr21:45109991 RRP1B 0.36 9.26 0.34 3.08e-19 Mean corpuscular volume; BRCA cis rs8038465 0.615 rs6495074 chr15:73959013 A/G cg15420318 chr15:73925796 NPTN 0.41 9.19 0.34 5.6e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg13906792 chr15:75199810 C15orf17 0.42 9.88 0.36 1.65e-21 Breast cancer; BRCA cis rs2549003 1.000 rs2070722 chr5:131824486 A/C cg02551604 chr5:131831745 NA -0.39 -15.08 -0.51 3.31e-44 Asthma (sex interaction); BRCA cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg15395560 chr15:45543142 SLC28A2 -0.29 -7.93 -0.3 9.69e-15 Uric acid levels; BRCA cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.68 15.67 0.53 4.73e-47 Axial length; BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg22800045 chr5:56110881 MAP3K1 0.68 12.5 0.44 3.23e-32 Initial pursuit acceleration; BRCA cis rs2297440 0.530 rs34533955 chr20:62233020 A/C cg16989086 chr20:62203971 PRIC285 0.53 8.83 0.33 9.74e-18 Glioma;Non-glioblastoma glioma;Glioblastoma; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.62 -0.42 1.8e-28 Gut microbiome composition (summer); BRCA cis rs13102973 0.867 rs12501608 chr4:135896365 T/C cg14419869 chr4:135874104 NA 0.47 9.41 0.35 9.03e-20 Subjective well-being; BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg16606324 chr3:10149918 C3orf24 0.57 11.38 0.41 1.88e-27 Alzheimer's disease; BRCA cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.77 -0.5 1.14e-42 Chronic sinus infection; BRCA cis rs35306767 0.903 rs35968821 chr10:910225 A/G cg20503657 chr10:835505 NA 1.05 18.41 0.59 5.1e-61 Eosinophil percentage of granulocytes; BRCA cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg27478167 chr7:817139 HEATR2 -0.58 -11.52 -0.41 4.8e-28 Cerebrospinal P-tau181p levels; BRCA cis rs11098499 0.697 rs4560394 chr4:120313435 T/G cg09307838 chr4:120376055 NA 0.7 14.75 0.5 1.38e-42 Corneal astigmatism; BRCA trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg03929089 chr4:120376271 NA -0.53 -8.81 -0.33 1.21e-17 Axial length; BRCA cis rs875971 0.545 rs12670811 chr7:65823019 C/A cg11764359 chr7:65958608 NA 0.65 11.62 0.42 1.81e-28 Aortic root size; BRCA cis rs312274 0.527 rs10879294 chr12:41263818 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -9.0 -0.34 2.5e-18 Metabolite levels (X-11787); BRCA cis rs11955398 0.625 rs6874072 chr5:59987682 C/G cg02684056 chr5:59996105 DEPDC1B 0.39 9.02 0.34 2.25e-18 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.654 rs11714373 chr3:47214817 G/A cg27129171 chr3:47204927 SETD2 -0.72 -17.57 -0.57 1.18e-56 Colorectal cancer; BRCA cis rs7945705 0.818 rs2742537 chr11:8908389 G/A cg12365402 chr11:9010492 NRIP3 -0.41 -9.31 -0.35 2.08e-19 Hemoglobin concentration; BRCA cis rs9649465 0.561 rs600420 chr7:123408050 G/A cg03229431 chr7:123269106 ASB15 0.44 10.17 0.37 1.27e-22 Migraine; BRCA cis rs9287719 0.967 rs7566767 chr2:10754663 T/C cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.81e-23 Prostate cancer; BRCA cis rs10504229 1.000 rs73607875 chr8:58173522 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg08470875 chr2:26401718 FAM59B -0.66 -11.41 -0.41 1.4e-27 Gut microbiome composition (summer); BRCA trans rs4718428 0.705 rs13231140 chr7:66361618 C/G cg18876405 chr7:65276391 NA 0.43 8.43 0.32 2.36e-16 Corneal structure; BRCA cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg08219700 chr8:58056026 NA 0.44 8.07 0.3 3.37e-15 Developmental language disorder (linguistic errors); BRCA cis rs573521 0.934 rs2155013 chr11:102701858 A/G cg15619439 chr11:102700944 NA -0.29 -8.22 -0.31 1.12e-15 Cerebrospinal fluid levels of Alzheimer's disease-related proteins; BRCA cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg13736514 chr6:26305472 NA -0.49 -15.67 -0.53 4.69e-47 Educational attainment; BRCA cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg03934865 chr2:198174659 NA -0.44 -9.57 -0.35 2.34e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg08219700 chr8:58056026 NA 0.45 8.14 0.31 2.05e-15 Developmental language disorder (linguistic errors); BRCA cis rs12545109 0.837 rs4738500 chr8:57356193 G/A cg09654669 chr8:57350985 NA -0.42 -8.03 -0.3 4.79e-15 Obesity-related traits; BRCA cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg08999081 chr20:33150536 PIGU 0.47 13.11 0.46 6.3e-35 Glomerular filtration rate (creatinine); BRCA cis rs7301016 0.846 rs11174576 chr12:63026436 C/T cg01804193 chr12:63026212 NA 0.45 7.93 0.3 9.51e-15 IgG glycosylation; BRCA cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.91 -0.33 5.2e-18 Bipolar disorder and schizophrenia; BRCA cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg26597838 chr10:835615 NA 1.28 21.53 0.65 9.42e-78 Eosinophil percentage of granulocytes; BRCA cis rs6121246 0.559 rs6087782 chr20:30391580 C/T cg13852791 chr20:30311386 BCL2L1 0.95 22.84 0.67 6.8e-85 Mean corpuscular hemoglobin; BRCA cis rs997295 0.554 rs28568344 chr15:68096527 A/G cg08079166 chr15:68083412 MAP2K5 0.31 8.32 0.31 5.13e-16 Motion sickness; BRCA cis rs7666738 0.791 rs1967978 chr4:98966152 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.577 rs2623049 chr12:38018831 G/A cg13010199 chr12:38710504 ALG10B -0.42 -8.9 -0.33 5.67e-18 Bladder cancer; BRCA cis rs9486719 0.895 rs34051754 chr6:97007754 A/T cg06623918 chr6:96969491 KIAA0776 -0.77 -13.98 -0.48 6.03e-39 Migraine;Coronary artery disease; BRCA trans rs79976124 0.837 rs74327235 chr6:66648353 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.75 0.39 6.67e-25 Type 2 diabetes; BRCA cis rs9309473 0.607 rs1851546 chr2:73591127 C/A cg20560298 chr2:73613845 ALMS1 -0.46 -12.45 -0.44 5.34e-32 Metabolite levels; BRCA cis rs1691799 0.528 rs1472314 chr12:66788838 C/G cg16791601 chr12:66731901 HELB -0.47 -11.05 -0.4 4.12e-26 White blood cell count (basophil); BRCA cis rs3733585 0.673 rs4407505 chr4:9953367 T/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.61e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg24846343 chr22:24311635 DDTL -0.44 -9.68 -0.36 8.71e-21 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs796364 0.951 rs1105964 chr2:201000776 T/A cg23649088 chr2:200775458 C2orf69 -0.58 -9.15 -0.34 7.82e-19 Schizophrenia; BRCA cis rs6977660 0.607 rs10243965 chr7:19797893 G/A cg07541023 chr7:19748670 TWISTNB 0.6 10.47 0.38 8.57e-24 Thyroid stimulating hormone; BRCA cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg00277334 chr10:82204260 NA -0.85 -25.05 -0.7 5.02e-97 Post bronchodilator FEV1; BRCA cis rs7617773 0.925 rs7374376 chr3:48172687 T/C cg11946769 chr3:48343235 NME6 -0.39 -8.51 -0.32 1.24e-16 Coronary artery disease; BRCA cis rs12760731 0.565 rs12048698 chr1:178136792 T/C cg00404053 chr1:178313656 RASAL2 0.64 7.87 0.3 1.56e-14 Obesity-related traits; BRCA cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs1005277 0.541 rs2505193 chr10:38394638 G/C cg23533926 chr12:111358616 MYL2 -0.41 -8.53 -0.32 1.05e-16 Extrinsic epigenetic age acceleration; BRCA cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg23029597 chr12:123009494 RSRC2 -0.5 -9.8 -0.36 3.33e-21 Body mass index; BRCA cis rs7301826 0.651 rs4759794 chr12:131297348 T/G cg11011512 chr12:131303247 STX2 0.5 13.03 0.46 1.42e-34 Plasma plasminogen activator levels; BRCA cis rs6546550 0.901 rs11126251 chr2:70163434 A/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.59 -0.42 2.59e-28 Prevalent atrial fibrillation; BRCA cis rs3820928 0.874 rs7563644 chr2:227846932 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.39 -0.32 3.08e-16 Pulmonary function; BRCA cis rs9814567 0.963 rs9844537 chr3:134238341 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.11 -0.34 1.08e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.66 -0.5 3.76e-42 Chronic sinus infection; BRCA cis rs2882667 0.867 rs11749045 chr5:138420960 C/T cg04439458 chr5:138467593 SIL1 -0.36 -9.81 -0.36 2.83e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7903847 0.642 rs11189174 chr10:99139600 C/G cg08345082 chr10:99160200 RRP12 -0.29 -8.62 -0.32 5.4e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6964587 1.000 rs6956431 chr7:91750016 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.0 0.3 5.83e-15 Breast cancer; BRCA cis rs477692 0.685 rs534430 chr10:131398734 A/C cg05714579 chr10:131428358 MGMT 0.54 12.38 0.44 1.07e-31 Response to temozolomide; BRCA cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg02153584 chr22:29168773 CCDC117 0.53 11.01 0.4 6.23e-26 Lymphocyte counts; BRCA cis rs9463078 0.683 rs227847 chr6:44695493 A/G cg25276700 chr6:44698697 NA 0.36 7.98 0.3 6.74e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6582630 0.519 rs11182021 chr12:38443709 A/T cg13010199 chr12:38710504 ALG10B -0.39 -8.39 -0.31 3.22e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9976767 0.637 rs9984108 chr21:43825628 T/G cg23042151 chr21:43824109 UBASH3A -0.27 -8.53 -0.32 1.1e-16 Type 1 diabetes; BRCA cis rs9486715 0.867 rs1855533 chr6:97050265 T/C cg06623918 chr6:96969491 KIAA0776 -0.92 -26.51 -0.72 5.11e-105 Headache; BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg08470875 chr2:26401718 FAM59B 0.72 10.08 0.37 2.89e-22 Gut microbiome composition (summer); BRCA cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.97 0.4 8.58e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.11 0.34 1.02e-18 Resting heart rate; BRCA cis rs801193 0.967 rs34356500 chr7:66236607 G/T cg11764359 chr7:65958608 NA 0.63 14.07 0.49 2.32e-39 Aortic root size; BRCA cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg11301795 chr4:187892539 NA -0.27 -9.11 -0.34 1.08e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.775 rs11514370 chr12:38305566 G/A cg13010199 chr12:38710504 ALG10B 0.45 9.35 0.35 1.5e-19 Bladder cancer; BRCA cis rs4285028 0.699 rs1344279 chr3:121615679 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.69 -12.09 -0.43 1.99e-30 Multiple sclerosis; BRCA cis rs713587 0.624 rs1550110 chr2:25124563 T/C cg01884057 chr2:25150051 NA 0.35 9.25 0.34 3.24e-19 Body mass index in non-asthmatics; BRCA cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.38 0.49 8.14e-41 Colorectal cancer; BRCA cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg06115741 chr20:33292138 TP53INP2 -0.38 -8.43 -0.32 2.22e-16 Glomerular filtration rate (creatinine); BRCA cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6543140 0.964 rs13393175 chr2:103078849 T/G cg04239558 chr2:103089729 SLC9A4 0.35 9.72 0.36 6.24e-21 Blood protein levels; BRCA cis rs10751667 0.643 rs10751666 chr11:941933 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs9309711 0.961 rs11678655 chr2:3476234 T/G cg16153549 chr2:3496821 NA -0.38 -8.63 -0.32 4.86e-17 Neurofibrillary tangles; BRCA cis rs1371614 0.577 rs877274 chr2:27140099 A/C cg00617064 chr2:27272375 NA 0.3 7.88 0.3 1.41e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7666738 0.546 rs1456207 chr4:98676911 G/A cg05340658 chr4:99064831 C4orf37 0.57 11.03 0.4 4.93e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg25237894 chr2:233734115 C2orf82 -0.45 -14.15 -0.49 1.02e-39 Coronary artery disease; BRCA cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg11742103 chr11:62369870 EML3;MTA2 0.53 13.42 0.47 2.32e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.84 -0.48 2.8e-38 Extrinsic epigenetic age acceleration; BRCA cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg22431228 chr1:16359049 CLCNKA -0.47 -10.81 -0.39 4.01e-25 Systolic blood pressure; BRCA cis rs13108904 0.901 rs6851528 chr4:1296009 G/A cg01939980 chr4:1354348 KIAA1530 0.31 8.13 0.31 2.29e-15 Obesity-related traits; BRCA cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg01028140 chr2:1542097 TPO -0.57 -11.59 -0.42 2.6e-28 IgG glycosylation; BRCA cis rs6582630 0.638 rs10880620 chr12:38517467 A/G cg26384229 chr12:38710491 ALG10B -0.46 -10.58 -0.39 3.31e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg22903471 chr2:27725779 GCKR -0.36 -8.73 -0.33 2.29e-17 Total body bone mineral density; BRCA cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg24642439 chr20:33292090 TP53INP2 0.41 8.1 0.31 2.71e-15 Height; BRCA cis rs208520 0.661 rs7747492 chr6:66857788 A/T cg07460842 chr6:66804631 NA -1.02 -20.25 -0.63 8.06e-71 Exhaled nitric oxide output; BRCA cis rs73001065 0.901 rs73004933 chr19:19675696 C/T cg03709012 chr19:19516395 GATAD2A 0.86 9.47 0.35 5.16e-20 LDL cholesterol; BRCA cis rs1829883 0.737 rs2548105 chr5:98905292 T/C cg08333243 chr5:99726346 NA 0.36 8.21 0.31 1.26e-15 Hemostatic factors and hematological phenotypes; BRCA trans rs75804782 0.515 rs79557340 chr2:239297952 G/A cg01134436 chr17:81009848 B3GNTL1 0.74 7.88 0.3 1.38e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg06671706 chr8:8559999 CLDN23 0.46 8.73 0.33 2.22e-17 Obesity-related traits; BRCA cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg27286337 chr10:134555280 INPP5A 0.66 11.48 0.41 7.52e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2249625 0.874 rs6917386 chr6:72898007 T/C cg18830697 chr6:72922368 RIMS1 0.37 7.86 0.3 1.63e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs59918340 0.548 rs10102728 chr8:142205964 G/A cg18755752 chr8:142205143 DENND3 -0.47 -11.0 -0.4 6.56e-26 Immature fraction of reticulocytes; BRCA cis rs6964587 0.967 rs2188153 chr7:91595117 G/T cg17063962 chr7:91808500 NA 0.53 12.53 0.44 2.28e-32 Breast cancer; BRCA cis rs1865721 0.771 rs7231277 chr18:73136724 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.64 -0.39 1.88e-24 Intelligence; BRCA cis rs11229555 0.645 rs10896774 chr11:58175837 T/G cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24110177 chr3:50126178 RBM5 0.35 9.65 0.36 1.19e-20 Intelligence (multi-trait analysis); BRCA cis rs10227331 0.934 rs2302447 chr7:157295985 A/T cg04156418 chr7:157293606 NA 0.37 10.7 0.39 1.1e-24 Inattentive symptoms; BRCA trans rs11098499 0.820 rs13128602 chr4:120459366 C/T cg19731845 chr4:166199412 KLHL2;GK3P -0.36 -8.13 -0.31 2.31e-15 Corneal astigmatism; BRCA cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg06238570 chr21:40685208 BRWD1 -0.4 -8.09 -0.3 3.08e-15 Menarche (age at onset); BRCA cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.32 -9.64 -0.36 1.3e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs7098414 0.511 rs4934134 chr10:82160582 C/T cg00277334 chr10:82204260 NA -0.48 -10.1 -0.37 2.42e-22 Post bronchodilator FEV1; BRCA cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.39 -7.85 -0.3 1.73e-14 Bipolar disorder; BRCA cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.91 -0.33 5.3e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg18479299 chr3:125709523 NA -0.54 -8.41 -0.32 2.74e-16 Blood pressure (smoking interaction); BRCA cis rs12586317 0.547 rs3759548 chr14:35450333 C/T cg16230307 chr14:35515116 FAM177A1 0.73 15.1 0.51 2.94e-44 Psoriasis; BRCA cis rs12497850 0.829 rs12636030 chr3:49182237 A/G cg06212747 chr3:49208901 KLHDC8B 0.52 10.78 0.39 5.39e-25 Parkinson's disease; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg07092213 chr7:1199455 ZFAND2A -0.4 -7.94 -0.3 9.33e-15 Longevity;Endometriosis; BRCA cis rs11955398 0.716 rs10939862 chr5:60001644 A/C cg02684056 chr5:59996105 DEPDC1B -0.41 -10.0 -0.37 5.92e-22 Intelligence (multi-trait analysis); BRCA cis rs6435161 1.000 rs72928934 chr2:203562740 A/G cg18429434 chr2:203499731 FAM117B -0.44 -8.64 -0.32 4.58e-17 Total cholesterol levels; BRCA cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg03474202 chr17:45855739 NA -0.48 -12.64 -0.45 7.39e-33 IgG glycosylation; BRCA cis rs6835098 0.924 rs1991727 chr4:174163169 A/G cg08422745 chr4:174089978 GALNT7 -0.64 -13.38 -0.47 3.7e-36 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs6598955 0.671 rs6681452 chr1:26621101 G/A cg04990556 chr1:26633338 UBXN11 0.54 9.04 0.34 1.79e-18 Obesity-related traits; BRCA cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg11764359 chr7:65958608 NA 0.62 13.47 0.47 1.38e-36 Aortic root size; BRCA trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg15556689 chr8:8085844 FLJ10661 0.38 9.97 0.37 7.35e-22 Triglycerides; BRCA cis rs2070488 0.965 rs1046048 chr3:38524742 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.16 0.62 2.58e-70 Electrocardiographic conduction measures; BRCA cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.4 -0.52 1.02e-45 Breast cancer; BRCA cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.37 8.06 0.3 3.85e-15 Platelet count; BRCA cis rs9790314 0.875 rs462514 chr3:161092809 C/T cg03342759 chr3:160939853 NMD3 -0.54 -12.07 -0.43 2.38e-30 Morning vs. evening chronotype; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg22907277 chr7:1156413 C7orf50 0.59 8.99 0.34 2.77e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1355223 0.525 rs7129517 chr11:34872236 A/C cg11058730 chr11:34937778 PDHX;APIP -0.47 -9.34 -0.35 1.58e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.83 0.39 3.26e-25 Rheumatoid arthritis; BRCA cis rs3768617 0.510 rs12086466 chr1:183075778 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.62 -16.38 -0.54 1.27e-50 Fuchs's corneal dystrophy; BRCA cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg01689657 chr7:91764605 CYP51A1 0.25 9.24 0.34 3.52e-19 Breast cancer; BRCA cis rs7565124 1.000 rs12472043 chr2:20256838 G/A cg23821541 chr2:20251993 LAPTM4A 0.38 7.98 0.3 6.79e-15 Major depressive disorder; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg08280861 chr8:58055591 NA 0.53 8.62 0.32 5.17e-17 Developmental language disorder (linguistic errors); BRCA cis rs6547741 0.844 rs55826602 chr2:27863452 A/G cg27432699 chr2:27873401 GPN1 -0.52 -11.02 -0.4 5.41e-26 Oral cavity cancer; BRCA cis rs3125734 0.572 rs7896627 chr10:64046354 T/G cg09941381 chr10:64027924 RTKN2 -0.29 -8.04 -0.3 4.37e-15 Rheumatoid arthritis; BRCA cis rs9814567 1.000 rs13059720 chr3:134242021 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9788721 0.836 rs11858836 chr15:78783277 G/A cg18825076 chr15:78729989 IREB2 -0.44 -8.32 -0.31 5.26e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs10876993 0.715 rs2169987 chr12:58012111 G/A cg18357645 chr12:58087776 OS9 -0.36 -9.41 -0.35 8.78e-20 Celiac disease or Rheumatoid arthritis; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg00080972 chr5:178986291 RUFY1 0.4 10.54 0.38 4.66e-24 Lung cancer; BRCA cis rs11252926 0.523 rs816596 chr10:548004 C/T cg03684893 chr10:554711 DIP2C -0.37 -8.2 -0.31 1.31e-15 Psychosis in Alzheimer's disease; BRCA cis rs9814567 0.929 rs9815297 chr3:134215052 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.31 -0.35 2.07e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs13217239 0.646 rs6937880 chr6:27000236 C/T cg12292205 chr6:26970375 C6orf41 0.58 13.03 0.46 1.3600000000000001e-34 Schizophrenia; BRCA cis rs61935443 0.832 rs11107773 chr12:95282000 C/T cg21533806 chr12:95267307 NA 0.44 8.46 0.32 1.76e-16 Schizophrenia; BRCA cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg24642439 chr20:33292090 TP53INP2 0.69 15.22 0.52 7.38e-45 Coronary artery disease; BRCA cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg23173402 chr1:227635558 NA 0.51 9.21 0.34 4.66e-19 Major depressive disorder; BRCA cis rs7607369 0.572 rs629177 chr2:219454801 T/G cg02176678 chr2:219576539 TTLL4 0.47 12.19 0.43 7.2e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 9.01e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA trans rs13219787 0.915 rs13214703 chr6:27941387 A/G cg12734449 chr6:30038004 PPP1R11 0.75 7.92 0.3 1.02e-14 Mean corpuscular volume;Hemoglobin levels;Mean corpuscular hemoglobin; BRCA cis rs4706831 0.625 rs638056 chr6:80980808 G/A cg08355045 chr6:80787529 NA -0.32 -8.35 -0.31 4.27e-16 Joint mobility (Beighton score); BRCA cis rs7666738 0.830 rs4292341 chr4:98959724 C/T cg17366294 chr4:99064904 C4orf37 0.37 8.76 0.33 1.78e-17 Colonoscopy-negative controls vs population controls; BRCA trans rs10771431 0.967 rs7137443 chr12:9372029 C/T cg27600084 chr12:12264075 NA 0.39 9.21 0.34 4.64e-19 Breast size; BRCA trans rs11088226 0.645 rs11702343 chr21:33937888 C/A cg09050820 chr6:167586206 TCP10L2 0.7 12.54 0.44 2.17e-32 Gastritis; BRCA cis rs875971 0.862 rs2420174 chr7:65645361 C/T cg18876405 chr7:65276391 NA -0.51 -11.65 -0.42 1.36e-28 Aortic root size; BRCA cis rs7772486 0.625 rs2050027 chr6:146116113 C/G cg05347473 chr6:146136440 FBXO30 -0.39 -7.9 -0.3 1.23e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs6878727 0.626 rs161007 chr5:123680383 C/T cg01806427 chr5:123737813 NA -0.37 -8.47 -0.32 1.63e-16 Breast cancer; BRCA cis rs2204008 0.683 rs7305703 chr12:38138381 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.06 0.51 4.47e-44 Bladder cancer; BRCA cis rs9469578 0.710 rs73743330 chr6:33713971 G/A cg18708504 chr6:33715942 IP6K3 0.7 10.18 0.37 1.12e-22 Phosphorus levels; BRCA cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg25208724 chr1:156163844 SLC25A44 1.04 34.14 0.8 3.67e-146 Testicular germ cell tumor; BRCA trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg08975724 chr8:8085496 FLJ10661 0.4 7.93 0.3 9.74e-15 Triglycerides; BRCA cis rs1008375 0.932 rs12500912 chr4:17603318 C/T cg04450456 chr4:17643702 FAM184B 0.36 10.63 0.39 2.11e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4478137 0.824 rs4057791 chr4:164225132 A/C cg06758707 chr4:164254230 NPY1R 0.57 12.31 0.44 2.14e-31 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs13046373 0.535 rs1605428 chr21:32028976 T/C cg06468780 chr21:31798236 KRTAP13-3 0.35 8.46 0.32 1.89e-16 HDL cholesterol; BRCA cis rs12477438 0.520 rs12621007 chr2:99791946 G/C cg08885076 chr2:99613938 TSGA10 0.43 10.22 0.37 8.29e-23 Chronic sinus infection; BRCA cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg10523679 chr1:76189770 ACADM 0.77 18.7 0.59 1.48e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg24130564 chr14:104152367 KLC1 -0.41 -8.73 -0.33 2.3e-17 Reticulocyte count; BRCA cis rs250677 0.524 rs417413 chr5:148452726 T/C cg18129178 chr5:148520854 ABLIM3 -0.48 -10.33 -0.38 2.99e-23 Breast cancer; BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.04 -0.43 3.02e-30 Alzheimer's disease; BRCA cis rs72772090 0.522 rs111620024 chr5:95998391 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -8.5 -0.32 1.3e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4974559 0.641 rs28647383 chr4:1312908 G/C cg02980000 chr4:1222292 CTBP1 0.81 13.33 0.47 6.09e-36 Systolic blood pressure; BRCA cis rs7592578 0.639 rs13417431 chr2:191293055 A/G cg10560079 chr2:191398806 TMEM194B -0.65 -12.18 -0.43 7.7e-31 Diastolic blood pressure; BRCA cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg20203395 chr5:56204925 C5orf35 0.41 9.14 0.34 7.96e-19 Initial pursuit acceleration; BRCA cis rs9323205 0.911 rs12587611 chr14:51641399 C/T cg23942311 chr14:51606299 NA -0.39 -8.92 -0.33 5.07e-18 Cancer; BRCA cis rs1127311 0.905 rs6699729 chr1:154582896 A/T cg17218026 chr1:154582156 ADAR 0.28 8.68 0.32 3.27e-17 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg23583168 chr7:148888333 NA -0.82 -18.48 -0.59 2e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10465746 0.570 rs12402130 chr1:84479838 G/A cg10977910 chr1:84465055 TTLL7 0.52 10.69 0.39 1.19e-24 Obesity-related traits; BRCA cis rs611744 0.647 rs2597658 chr8:109256014 C/T cg21045802 chr8:109455806 TTC35 0.36 7.99 0.3 6.36e-15 Dupuytren's disease; BRCA cis rs1348850 0.554 rs7595576 chr2:178371921 C/T cg27490568 chr2:178487706 NA 0.51 8.58 0.32 7.29e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11792861 0.781 rs874864 chr9:111728718 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.54 11.14 0.4 1.75e-26 Menarche (age at onset); BRCA cis rs7762018 1.000 rs73242910 chr6:170114670 A/G cg19338460 chr6:170058176 WDR27 -0.46 -8.11 -0.31 2.69e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA trans rs6952808 0.594 rs3778964 chr7:2138109 C/T cg04565464 chr8:145669602 NFKBIL2 0.44 9.94 0.37 9.65e-22 Bipolar disorder and schizophrenia; BRCA cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 14.17 0.49 8.02e-40 Colorectal cancer; BRCA cis rs17023223 0.509 rs61806978 chr1:119713215 A/G cg05756136 chr1:119680316 WARS2 -0.41 -7.98 -0.3 6.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg06784218 chr1:46089804 CCDC17 -0.43 -10.13 -0.37 1.82e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs61931739 0.517 rs860950 chr12:34104376 C/G cg06521331 chr12:34319734 NA -0.62 -12.2 -0.43 6.08e-31 Morning vs. evening chronotype; BRCA cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.29 0.61 1.07e-65 Smoking behavior; BRCA cis rs7072216 0.727 rs942808 chr10:100168102 C/A cg26618903 chr10:100175079 PYROXD2 -0.31 -8.96 -0.33 3.58e-18 Metabolite levels; BRCA cis rs3741404 0.665 rs594461 chr11:63872543 A/G cg18225595 chr11:63971243 STIP1 0.4 9.86 0.36 1.89e-21 Platelet count; BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -11.21 -0.41 9.24e-27 Bipolar disorder and schizophrenia; BRCA cis rs11190604 1.000 rs12358187 chr10:102284449 C/G cg07080220 chr10:102295463 HIF1AN 0.62 14.55 0.5 1.2e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.05 0.3 4.09e-15 Diabetic retinopathy; BRCA trans rs72766638 0.806 rs56303154 chr9:136936376 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.63 -9.16 -0.34 7e-19 Mosquito bite size; BRCA cis rs1011018 0.628 rs12155449 chr7:139475320 C/T cg03224163 chr7:139420300 HIPK2 0.59 8.94 0.33 4.08e-18 Systolic blood pressure; BRCA cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg03916912 chr11:95522834 CEP57;FAM76B -0.77 -19.45 -0.61 1.58e-66 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.19 0.4 1.1e-26 Bipolar disorder; BRCA cis rs6088813 1.000 rs6088823 chr20:33994265 G/T cg14752227 chr20:34000481 UQCC -0.43 -9.14 -0.34 7.97e-19 Height; BRCA cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.43e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2688608 0.592 rs11814282 chr10:75490217 T/C cg23231163 chr10:75533350 FUT11 -0.33 -8.65 -0.32 4.1e-17 Inflammatory bowel disease; BRCA cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7264396 0.733 rs2425105 chr20:34312834 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -16.19 -0.54 1.18e-49 Total cholesterol levels; BRCA cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12516959 chr21:47718080 NA -0.42 -9.62 -0.36 1.53e-20 Testicular germ cell tumor; BRCA cis rs477692 0.685 rs3852507 chr10:131399616 G/T cg24747557 chr10:131355152 MGMT 0.38 9.6 0.36 1.79e-20 Response to temozolomide; BRCA cis rs61931739 0.500 rs7308338 chr12:34553181 A/G cg06521331 chr12:34319734 NA -0.51 -10.09 -0.37 2.62e-22 Morning vs. evening chronotype; BRCA cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg06627628 chr2:24431161 ITSN2 -0.5 -8.05 -0.3 4.02e-15 Lymphocyte counts; BRCA cis rs9473147 0.516 rs9381575 chr6:47528764 C/G cg12968598 chr6:47444699 CD2AP 0.44 9.61 0.36 1.61e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA trans rs3774749 0.565 rs2518795 chr3:50208819 C/T cg21659725 chr3:3221576 CRBN 0.36 8.21 0.31 1.18e-15 Intelligence (multi-trait analysis); BRCA cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -11.25 -0.41 6.26e-27 Schizophrenia; BRCA cis rs7737355 0.947 rs40989 chr5:130992284 T/G cg06307176 chr5:131281290 NA 0.53 10.39 0.38 1.87e-23 Life satisfaction; BRCA cis rs7091068 0.536 rs6583901 chr10:95409998 C/T cg20715218 chr10:95462985 C10orf4 -0.56 -10.39 -0.38 1.81e-23 Urinary tract infection frequency; BRCA cis rs10181042 0.514 rs1177283 chr2:61348804 A/G cg15711740 chr2:61764176 XPO1 -0.38 -8.83 -0.33 9.85e-18 Crohn's disease; BRCA cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg05347473 chr6:146136440 FBXO30 -0.43 -8.57 -0.32 7.59e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg08045932 chr20:61659980 NA 0.5 11.48 0.41 7.29e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.54 0.32 9.95e-17 Electroencephalogram traits; BRCA cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12756686 chr19:29218302 NA 0.58 11.74 0.42 6.06e-29 Methadone dose in opioid dependence; BRCA cis rs17092148 0.887 rs6059916 chr20:33148861 T/G cg16810054 chr20:33298113 TP53INP2 -0.45 -10.13 -0.37 1.75e-22 Neuroticism; BRCA cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg25237894 chr2:233734115 C2orf82 -0.38 -10.86 -0.39 2.45e-25 Coronary artery disease; BRCA cis rs8064299 0.597 rs4789097 chr17:72781208 C/T cg25054828 chr17:72772726 NAT9;TMEM104 -0.65 -20.0 -0.62 1.7e-69 Monocyte count; BRCA cis rs4727027 0.933 rs12704063 chr7:148827909 T/C cg23583168 chr7:148888333 NA -0.85 -19.73 -0.62 4.99e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6942756 0.876 rs2303303 chr7:129019736 G/A cg02491457 chr7:128862824 NA -0.61 -12.47 -0.44 4.18e-32 White matter hyperintensity burden; BRCA cis rs61931739 0.500 rs11615231 chr12:34413330 T/C cg06521331 chr12:34319734 NA -0.56 -10.08 -0.37 2.87e-22 Morning vs. evening chronotype; BRCA cis rs4690686 0.500 rs7667671 chr4:177275599 T/C cg17059388 chr4:177262070 NA 0.51 10.72 0.39 9.33e-25 Essential tremor; BRCA cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg27129171 chr3:47204927 SETD2 0.71 16.88 0.56 3.83e-53 Colorectal cancer; BRCA cis rs74417235 0.684 rs12655636 chr5:154057618 T/C cg08754654 chr5:154026448 NA 0.43 9.99 0.37 6.1e-22 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs6582630 0.502 rs1607867 chr12:38385463 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.4 0.38 1.67e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs765787 0.530 rs2413784 chr15:45530516 A/C cg15395560 chr15:45543142 SLC28A2 0.29 8.23 0.31 1.02e-15 Uric acid levels; BRCA trans rs12517041 1.000 rs10066885 chr5:23296872 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs912057 0.585 rs1745341 chr6:6744990 T/C cg06612196 chr6:6737390 NA 0.46 10.79 0.39 4.81e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA trans rs6479891 1.000 rs77494594 chr10:65197309 A/C cg14819942 chr15:35414228 NA 0.35 8.6 0.32 6e-17 Arthritis (juvenile idiopathic); BRCA trans rs7824557 0.843 rs2736375 chr8:11115749 C/T cg15556689 chr8:8085844 FLJ10661 -0.37 -9.26 -0.34 3.07e-19 Retinal vascular caliber; BRCA cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.34e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs67311347 1.000 rs9835219 chr3:40424093 C/T cg01475735 chr3:40494733 NA -0.4 -8.19 -0.31 1.47e-15 Renal cell carcinoma; BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg11062466 chr8:58055876 NA 0.5 8.72 0.33 2.44e-17 Developmental language disorder (linguistic errors); BRCA cis rs4853012 0.838 rs58759652 chr2:74344902 A/T cg19729930 chr2:74357872 NA 0.59 14.48 0.5 2.66e-41 Gestational age at birth (maternal effect); BRCA cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2762353 0.904 rs13197601 chr6:25785935 G/A cg03264133 chr6:25882463 NA 0.51 11.35 0.41 2.49e-27 Blood metabolite levels; BRCA cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg08213375 chr14:104286397 PPP1R13B 0.59 16.49 0.55 3.58e-51 Schizophrenia; BRCA cis rs75229567 0.618 rs11177848 chr12:70180892 A/G cg10114359 chr12:70132523 RAB3IP 1.13 12.96 0.46 2.8e-34 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg22963979 chr7:1858916 MAD1L1 -0.45 -9.06 -0.34 1.6e-18 Bipolar disorder and schizophrenia; BRCA cis rs9324022 0.929 rs72698718 chr14:101178555 G/A cg18089426 chr14:101175970 NA 0.64 12.18 0.43 7.4e-31 Plateletcrit; BRCA cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg20933634 chr6:27740509 NA 0.43 8.38 0.31 3.39e-16 Parkinson's disease; BRCA cis rs17092148 1.000 rs6060043 chr20:33364584 C/T cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.52 -10.65 -0.39 1.65e-24 Systemic lupus erythematosus; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg00814883 chr7:100076585 TSC22D4 -0.55 -11.83 -0.42 2.48e-29 Platelet count; BRCA trans rs9944715 1.000 rs6507690 chr18:43808597 A/G cg01718231 chr17:29326311 RNF135 -0.44 -8.59 -0.32 6.9e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.96 -0.33 3.42e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs6684514 1.000 rs10908495 chr1:156263940 T/C cg16558208 chr1:156270281 VHLL 0.35 8.18 0.31 1.57e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA trans rs6479891 1.000 rs4746149 chr10:65257393 C/T cg14819942 chr15:35414228 NA -0.33 -8.09 -0.3 2.97e-15 Arthritis (juvenile idiopathic); BRCA cis rs1215050 0.791 rs968854 chr4:98837863 T/C cg05340658 chr4:99064831 C4orf37 0.43 9.84 0.36 2.33e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.830 rs7698771 chr4:98986479 T/G cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs651907 0.557 rs7612283 chr3:101434919 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.8 0.51 7.85e-43 Colorectal cancer; BRCA cis rs9914988 0.778 rs35398767 chr17:27122960 A/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs11098499 0.754 rs878372 chr4:120238780 A/C cg25214090 chr10:38739885 LOC399744 0.45 10.3 0.38 4.15e-23 Corneal astigmatism; BRCA cis rs1790761 0.667 rs4147581 chr11:67351585 C/G cg00864171 chr11:67383662 NA 0.4 8.25 0.31 9.18e-16 Mean corpuscular volume; BRCA cis rs798554 0.591 rs757791 chr7:2867296 A/G cg18446336 chr7:2847575 GNA12 -0.37 -8.58 -0.32 7.39e-17 Height; BRCA cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.09e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10782582 0.609 rs2029682 chr1:76341619 T/C cg10523679 chr1:76189770 ACADM -0.42 -8.01 -0.3 5.55e-15 Daytime sleep phenotypes; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.14 -0.31 2.05e-15 Total body bone mineral density; BRCA cis rs1881797 1.000 rs67977965 chr1:247687835 G/A cg11166453 chr1:247681781 NA 0.41 9.21 0.34 4.64e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.28 -0.44 3e-31 Personality dimensions; BRCA trans rs11039798 0.588 rs10160381 chr11:48599491 A/G cg15704280 chr7:45808275 SEPT13 0.51 8.9 0.33 5.58e-18 Axial length; BRCA cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg06784218 chr1:46089804 CCDC17 -0.52 -12.34 -0.44 1.54e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6964587 0.869 rs10242792 chr7:91492103 A/C cg17063962 chr7:91808500 NA 0.52 11.98 0.43 5.41e-30 Breast cancer; BRCA cis rs7264396 0.622 rs3787165 chr20:34228946 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.22 0.31 1.13e-15 Total cholesterol levels; BRCA cis rs6598955 0.671 rs12116908 chr1:26587918 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs4243830 0.737 rs4908909 chr1:6599041 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -16.07 -0.54 4.79e-49 Body mass index; BRCA cis rs250677 0.687 rs250672 chr5:148446110 A/G cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.89e-31 Breast cancer; BRCA cis rs9649465 1.000 rs7803287 chr7:123354807 T/C cg04330084 chr7:123175371 IQUB -0.33 -8.99 -0.34 2.7e-18 Migraine; BRCA cis rs72627123 0.867 rs11848920 chr14:74476866 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.66 7.93 0.3 9.8e-15 Morning vs. evening chronotype; BRCA cis rs813218 0.565 rs4244712 chr3:99679461 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -8.7 -0.33 2.74e-17 Orofacial clefts; BRCA trans rs5756813 0.635 rs11089856 chr22:38205784 A/C cg19894588 chr14:64061835 NA -0.55 -11.55 -0.42 3.67e-28 Optic cup area;Vertical cup-disc ratio; BRCA cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg02503808 chr4:7069936 GRPEL1 0.77 14.68 0.5 2.93e-42 Monocyte percentage of white cells; BRCA cis rs6582630 0.516 rs8186746 chr12:38347638 G/T cg26384229 chr12:38710491 ALG10B -0.41 -9.5 -0.35 4.18e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs7631605 0.935 rs4234259 chr3:37048633 A/G cg15934958 chr3:37212084 LRRFIP2 0.42 9.58 0.35 2.08e-20 Cerebrospinal P-tau181p levels; BRCA cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg00990874 chr7:1149470 C7orf50 0.63 13.47 0.47 1.36e-36 Bronchopulmonary dysplasia; BRCA cis rs11098499 0.909 rs9759478 chr4:120367998 G/A cg09307838 chr4:120376055 NA 0.71 14.77 0.5 1.14e-42 Corneal astigmatism; BRCA cis rs12586317 0.547 rs2273154 chr14:35433187 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.15 -0.37 1.55e-22 Psoriasis; BRCA cis rs7707921 0.767 rs862242 chr5:81587566 C/T cg15871215 chr5:81402204 ATG10 -0.35 -8.32 -0.31 5.3e-16 Breast cancer; BRCA cis rs4803468 1.000 rs878082 chr19:41897674 G/A cg09537434 chr19:41945824 ATP5SL -1.0 -24.49 -0.7 6.73e-94 Height; BRCA cis rs6120849 0.707 rs6120798 chr20:33610822 T/G cg24642439 chr20:33292090 TP53INP2 0.6 10.36 0.38 2.31e-23 Protein C levels; BRCA cis rs1975991 0.711 rs1479935 chr3:187966711 A/G cg15417654 chr3:187959138 LPP 0.32 8.17 0.31 1.61e-15 White matter integrity (bipolar disorder risk interaction); BRCA cis rs4466137 0.830 rs6886442 chr5:82973210 A/C cg16102102 chr5:83017553 HAPLN1 0.74 15.13 0.51 1.91e-44 Prostate cancer; BRCA cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.83 -0.51 5.74e-43 Chronic sinus infection; BRCA cis rs990171 0.607 rs871659 chr2:102771855 C/T cg22835712 chr2:102737379 NA 0.52 9.56 0.35 2.4e-20 Lymphocyte counts; BRCA cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg18016565 chr1:150552671 MCL1 0.34 7.81 0.3 2.35e-14 Melanoma; BRCA cis rs4803455 0.565 rs1025497 chr19:41871254 A/G cg08477640 chr19:41863820 B9D2 0.39 8.01 0.3 5.29e-15 Migraine;Coronary artery disease; BRCA cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07930192 chr7:1003750 NA 0.48 10.57 0.39 3.65e-24 Longevity;Endometriosis; BRCA cis rs854572 0.600 rs705382 chr7:94955221 C/G cg21856205 chr7:94953877 PON1 -0.37 -8.65 -0.32 4.02e-17 Paraoxonase activity; BRCA cis rs7586879 0.575 rs6706316 chr2:25128351 C/G cg04586622 chr2:25135609 ADCY3 0.46 11.5 0.41 6.1e-28 Body mass index; BRCA cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg05347473 chr6:146136440 FBXO30 0.4 8.01 0.3 5.27e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4891159 0.570 rs690132 chr18:74117261 T/C cg24786174 chr18:74118243 ZNF516 0.84 26.02 0.72 2.36e-102 Longevity; BRCA cis rs13064411 0.696 rs3732803 chr3:113211957 T/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.34 -0.44 1.56e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg26384229 chr12:38710491 ALG10B -0.61 -14.36 -0.49 9.65e-41 Morning vs. evening chronotype; BRCA cis rs72772090 0.520 rs56325109 chr5:96112295 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.08 -0.43 2.05e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6700896 0.832 rs11208693 chr1:66108063 C/T cg04111102 chr1:66153794 NA 0.34 8.44 0.32 2.2e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.94e-30 Tonsillectomy; BRCA cis rs28374715 0.635 rs112547435 chr15:41648737 C/G cg18705301 chr15:41695430 NDUFAF1 -0.91 -21.7 -0.65 1.23e-78 Ulcerative colitis; BRCA cis rs6815814 0.950 rs5743560 chr4:38806200 G/T cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg00071950 chr4:10020882 SLC2A9 0.55 13.2 0.46 2.4e-35 Bone mineral density; BRCA cis rs10128251 0.625 rs9424204 chr10:5726376 C/G cg24097872 chr10:5724021 NA 0.47 10.56 0.39 3.9e-24 Childhood ear infection; BRCA cis rs11971779 0.680 rs1986447 chr7:139082080 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg18964960 chr10:1102726 WDR37 -0.47 -8.45 -0.32 2.02e-16 Response to angiotensin II receptor blocker therapy; BRCA cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg11752832 chr7:134001865 SLC35B4 0.42 9.94 0.37 9.34e-22 Mean platelet volume; BRCA cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.74 0.42 5.96e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs754466 0.914 rs12218917 chr10:79701479 C/T cg17075019 chr10:79541650 NA -0.64 -12.18 -0.43 7.91e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2011503 1.000 rs7252453 chr19:19654117 G/C cg11584989 chr19:19387371 SF4 0.49 10.97 0.4 8.7e-26 Bipolar disorder; BRCA cis rs9640161 0.663 rs1916932 chr7:150021644 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.55 -13.94 -0.48 9.13e-39 Blood protein levels;Circulating chemerin levels; BRCA cis rs875971 0.964 rs778708 chr7:65856319 T/C cg12463550 chr7:65579703 CRCP 0.36 7.82 0.3 2.19e-14 Aortic root size; BRCA cis rs11098499 0.754 rs9999724 chr4:120239944 C/T cg09307838 chr4:120376055 NA 0.63 13.63 0.47 2.52e-37 Corneal astigmatism; BRCA cis rs9486719 0.843 rs2499797 chr6:96848669 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.25 0.44 3.7e-31 Migraine;Coronary artery disease; BRCA cis rs7945718 0.781 rs10741604 chr11:12840940 C/A cg25843174 chr11:12811716 TEAD1 0.22 8.39 0.32 3.09e-16 Educational attainment (years of education); BRCA cis rs6598955 0.502 rs6683157 chr1:26545865 G/A cg12744634 chr1:26560303 CCDC21 0.3 8.19 0.31 1.48e-15 Obesity-related traits; BRCA cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg04267008 chr7:1944627 MAD1L1 -0.5 -10.92 -0.4 1.42e-25 Bipolar disorder and schizophrenia; BRCA cis rs3008870 0.727 rs11208971 chr1:67383901 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.65 0.48 2.17e-37 Lymphocyte percentage of white cells; BRCA cis rs9291683 0.588 rs34501273 chr4:9996996 C/T cg00071950 chr4:10020882 SLC2A9 0.55 13.92 0.48 1.16e-38 Bone mineral density; BRCA cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg13010199 chr12:38710504 ALG10B 0.51 9.99 0.37 6.41e-22 Morning vs. evening chronotype; BRCA cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg10523679 chr1:76189770 ACADM 0.91 22.34 0.66 4.07e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs57504626 1 rs57504626 chr19:19720399 C/T cg03709012 chr19:19516395 GATAD2A 0.76 9.66 0.36 1.08e-20 Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs7727544 0.625 rs4705916 chr5:131407493 C/A cg14196790 chr5:131705035 SLC22A5 0.38 9.35 0.35 1.4e-19 Blood metabolite levels; BRCA cis rs701145 0.640 rs357495 chr3:153939099 A/G cg17054900 chr3:154042577 DHX36 0.43 8.18 0.31 1.59e-15 Coronary artery disease; BRCA cis rs870825 0.616 rs28558715 chr4:185627761 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7246657 0.551 rs12978093 chr19:37584416 C/T cg23950597 chr19:37808831 NA -0.64 -9.66 -0.36 1.1e-20 Coronary artery calcification; BRCA trans rs629535 0.814 rs651985 chr8:70054966 G/A cg21567404 chr3:27674614 NA 1.0 21.21 0.64 5.39e-76 Dupuytren's disease; BRCA cis rs523522 0.962 rs4767912 chr12:120981202 A/G cg27279351 chr12:120934652 DYNLL1 0.56 13.24 0.46 1.54e-35 High light scatter reticulocyte count; BRCA cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg08999081 chr20:33150536 PIGU 0.47 13.03 0.46 1.35e-34 Glomerular filtration rate (creatinine); BRCA cis rs992157 0.798 rs2382817 chr2:219151218 A/C cg20019365 chr2:219134978 PNKD;AAMP 0.52 11.22 0.41 8.92e-27 Colorectal cancer; BRCA cis rs734999 0.870 rs2147905 chr1:2482921 C/T cg18854424 chr1:2615690 NA -0.33 -7.81 -0.3 2.36e-14 Ulcerative colitis; BRCA cis rs3733585 0.762 rs6449217 chr4:10009151 T/A cg11266682 chr4:10021025 SLC2A9 0.42 10.77 0.39 5.93e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg11764359 chr7:65958608 NA -0.79 -19.5 -0.61 8.84e-67 Aortic root size; BRCA cis rs17401966 0.838 rs1556917 chr1:10400990 G/T cg19773385 chr1:10388646 KIF1B -0.35 -7.82 -0.3 2.17e-14 Hepatocellular carcinoma; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs13394619 0.655 rs7578132 chr2:11718858 C/T cg07314298 chr2:11723111 GREB1 -0.42 -9.38 -0.35 1.17e-19 Endometriosis; BRCA cis rs1003719 0.788 rs2040341 chr21:38489753 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.14 0.49 1.04e-39 Eye color traits; BRCA cis rs73086581 1.000 rs6052209 chr20:3961747 G/A cg02187196 chr20:3869020 PANK2 0.51 9.22 0.34 4.42e-19 Response to antidepressants in depression; BRCA cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg02574844 chr11:5959923 NA -0.43 -8.44 -0.32 2.11e-16 DNA methylation (variation); BRCA cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg03713592 chr11:72463424 ARAP1 0.62 11.08 0.4 3.08e-26 Body mass index; BRCA cis rs9612 1.000 rs346527 chr19:44259361 A/G cg08581076 chr19:44259116 C19orf61 0.53 9.76 0.36 4.57e-21 Exhaled nitric oxide output; BRCA cis rs61931739 0.500 rs7965679 chr12:34542494 T/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg16586182 chr3:47516702 SCAP 0.54 11.96 0.43 6.69e-30 Colorectal cancer; BRCA cis rs7666738 0.800 rs10008654 chr4:98820498 C/A cg05340658 chr4:99064831 C4orf37 0.62 14.77 0.5 1.09e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs67142569 chr1:46828460 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.76 0.36 4.52e-21 Menopause (age at onset); BRCA cis rs7917772 0.636 rs2482499 chr10:104516246 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 10.25 0.38 6.08e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.37 8.43 0.32 2.37e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs903263 0.601 rs12746741 chr1:84539576 C/T cg10977910 chr1:84465055 TTLL7 -0.41 -8.11 -0.31 2.6e-15 Breast cancer (male); BRCA cis rs9486719 0.947 rs11755945 chr6:96908038 G/C cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.72e-34 Migraine;Coronary artery disease; BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.56 -9.58 -0.35 2.2e-20 Gut microbiome composition (summer); BRCA trans rs11039798 1.000 rs7125913 chr11:48984318 G/A cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.55e-18 Axial length; BRCA cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg06671706 chr8:8559999 CLDN23 0.41 8.08 0.3 3.18e-15 Obesity-related traits; BRCA cis rs6582630 0.598 rs12823134 chr12:38514347 T/A cg26384229 chr12:38710491 ALG10B -0.43 -10.03 -0.37 4.51e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg24110177 chr3:50126178 RBM5 -0.53 -15.89 -0.53 3.57e-48 Intelligence (multi-trait analysis); BRCA cis rs1832871 0.672 rs1342211 chr6:158759496 G/T cg07165851 chr6:158734300 TULP4 0.63 12.66 0.45 6.08e-33 Height; BRCA cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg06618935 chr21:46677482 NA -0.36 -7.98 -0.3 6.65e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg25173405 chr17:45401733 C17orf57 0.52 11.24 0.41 7.13e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg25358565 chr5:93447407 FAM172A 1.18 17.78 0.58 9.73e-58 Diabetic retinopathy; BRCA cis rs1059312 0.932 rs4760592 chr12:129287149 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.29 9.38 0.35 1.13e-19 Systemic lupus erythematosus; BRCA cis rs7584330 0.737 rs1390985 chr2:238367420 G/A cg14458575 chr2:238380390 NA 0.44 9.92 0.37 1.09e-21 Prostate cancer; BRCA cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg10174797 chr19:8464628 RAB11B 0.35 9.01 0.34 2.4e-18 HDL cholesterol; BRCA cis rs9807989 0.507 rs1035129 chr2:103019785 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.25e-16 Asthma; BRCA cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg22509189 chr2:225307070 NA -0.47 -10.07 -0.37 3.17e-22 IgE levels in asthmatics (D.p. specific); BRCA cis rs870825 0.616 rs2090590 chr4:185647850 A/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs9296092 0.538 rs75501442 chr6:33519493 A/G cg13560919 chr6:33536144 NA -0.85 -18.62 -0.59 3.9e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs739401 0.611 rs494427 chr11:3048140 A/G cg08508325 chr11:3079039 CARS -0.42 -15.01 -0.51 7.5e-44 Longevity; BRCA cis rs889312 0.500 rs252920 chr5:56148741 C/A cg24531977 chr5:56204891 C5orf35 -0.4 -8.09 -0.3 3.01e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs9790314 0.628 rs1599381 chr3:160867680 G/A cg03342759 chr3:160939853 NMD3 -0.59 -13.0 -0.46 1.99e-34 Morning vs. evening chronotype; BRCA cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg26597838 chr10:835615 NA 1.0 17.38 0.57 1.05e-55 Eosinophil percentage of granulocytes; BRCA cis rs2742234 0.911 rs3004214 chr10:43631698 C/T cg15436174 chr10:43711423 RASGEF1A -0.47 -9.3 -0.35 2.2e-19 Hirschsprung disease; BRCA cis rs4535700 0.501 rs6943341 chr7:55975182 A/T cg09872392 chr7:56161020 PHKG1 0.35 7.98 0.3 6.6e-15 Macular telangiectasia type 2; BRCA cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs208515 0.525 rs12191500 chr6:66668681 A/G cg07460842 chr6:66804631 NA 0.86 15.43 0.52 6.88e-46 Exhaled nitric oxide levels; BRCA cis rs2011503 0.882 rs2060276 chr19:19522491 T/G cg15839431 chr19:19639596 YJEFN3 -0.44 -8.94 -0.33 4.1e-18 Bipolar disorder; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.06 -23.45 -0.68 3.31e-88 Gut microbiome composition (summer); BRCA cis rs365132 0.875 rs4976665 chr5:176352736 C/T cg16309518 chr5:176445507 NA -0.39 -9.67 -0.36 9.9e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.56 0.35 2.41e-20 Parkinson's disease; BRCA cis rs35110281 0.633 rs4818860 chr21:45119617 C/T cg01579765 chr21:45077557 HSF2BP -0.42 -11.45 -0.41 9.66e-28 Mean corpuscular volume; BRCA trans rs6582630 0.513 rs11181246 chr12:38302670 C/T cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs72781680 0.768 rs112139157 chr2:24150783 A/C cg08917208 chr2:24149416 ATAD2B 0.63 10.68 0.39 1.25e-24 Lymphocyte counts; BRCA cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg04455712 chr21:45112962 RRP1B 0.44 11.82 0.42 2.69e-29 Mean corpuscular volume; BRCA cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11890956 chr21:40555474 PSMG1 -0.94 -23.53 -0.68 1.25e-88 Cognitive function; BRCA cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg18402987 chr7:1209562 NA 0.78 11.73 0.42 6.37e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg21770322 chr7:97807741 LMTK2 -0.41 -10.98 -0.4 8.06e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg00106254 chr7:1943704 MAD1L1 -0.45 -11.77 -0.42 4.4e-29 Bipolar disorder and schizophrenia; BRCA cis rs1551570 0.755 rs11667630 chr19:10229297 A/C cg16327482 chr19:10226339 EIF3G -0.39 -10.07 -0.37 3.19e-22 Narcolepsy; BRCA cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg23029597 chr12:123009494 RSRC2 0.62 11.97 0.43 6e-30 Body mass index; BRCA cis rs2880765 0.835 rs7162502 chr15:86044473 G/T cg10818794 chr15:86012489 AKAP13 -0.3 -8.5 -0.32 1.34e-16 Coronary artery disease; BRCA cis rs1538970 0.847 rs1771550 chr1:45883565 C/T cg05343316 chr1:45956843 TESK2 -0.54 -11.14 -0.4 1.9e-26 Platelet count; BRCA cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg12165864 chr7:66369176 NA -0.44 -9.93 -0.37 1.07e-21 Corneal structure; BRCA cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.29 0.41 4.54e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg09184832 chr6:79620586 NA -0.52 -11.37 -0.41 2.02e-27 Intelligence (multi-trait analysis); BRCA cis rs11955398 0.716 rs12514253 chr5:59998301 G/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.26 0.34 2.94e-19 Intelligence (multi-trait analysis); BRCA cis rs1368882 0.814 rs1702020 chr1:55105728 C/T cg01517571 chr1:55089959 ACOT11;FAM151A 0.43 9.12 0.34 9.66e-19 Non-substance related behavioral disinhibition; BRCA cis rs6942756 0.712 rs6467241 chr7:128997838 A/G cg02491457 chr7:128862824 NA -0.6 -12.37 -0.44 1.15e-31 White matter hyperintensity burden; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg16339924 chr4:17578868 LAP3 0.54 13.0 0.46 1.89e-34 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7267979 0.966 rs2482918 chr20:25412135 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.66 -0.32 3.86e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs911555 0.755 rs55742283 chr14:103942965 A/G cg17675199 chr6:35436792 RPL10A -0.3 -8.14 -0.31 2e-15 Intelligence (multi-trait analysis); BRCA cis rs950169 0.579 rs12913054 chr15:84664456 A/G cg17507749 chr15:85114479 UBE2QP1 0.55 9.01 0.34 2.37e-18 Schizophrenia; BRCA cis rs9400271 0.527 rs11759230 chr6:109640321 A/C cg01475377 chr6:109611718 NA 0.36 7.96 0.3 7.82e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg20203395 chr5:56204925 C5orf35 -0.52 -10.93 -0.4 1.26e-25 Initial pursuit acceleration; BRCA cis rs490234 0.702 rs5016056 chr9:128310807 C/T cg14078157 chr9:128172775 NA -0.53 -11.58 -0.42 2.68e-28 Mean arterial pressure; BRCA cis rs9942416 0.660 rs4704234 chr5:75001432 A/G cg19683494 chr5:74908142 NA 0.43 8.37 0.31 3.66e-16 Age-related disease endophenotypes; BRCA cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.34 0.41 2.88e-27 Electroencephalogram traits; BRCA cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg00071950 chr4:10020882 SLC2A9 0.57 14.09 0.49 1.89e-39 Bone mineral density; BRCA cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg11764359 chr7:65958608 NA -0.66 -12.11 -0.43 1.53e-30 Aortic root size; BRCA cis rs4664304 0.620 rs11675122 chr2:160713446 C/A cg01092293 chr2:160761427 LY75 0.35 8.29 0.31 6.6e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs734999 1.000 rs10797432 chr1:2501338 C/T cg20673091 chr1:2541236 MMEL1 0.32 8.44 0.32 2.17e-16 Ulcerative colitis; BRCA cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg21573476 chr21:45109991 RRP1B -0.36 -9.03 -0.34 2e-18 Mean corpuscular volume; BRCA cis rs9682041 0.696 rs11927807 chr3:170096623 A/G cg11886554 chr3:170076028 SKIL 0.51 10.2 0.37 9.77e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs9420 0.890 rs547891 chr11:57499065 C/T cg19752551 chr11:57585705 CTNND1 0.42 10.79 0.39 4.69e-25 Schizophrenia; BRCA cis rs1165205 0.500 rs629835 chr6:25879330 T/C cg12310025 chr6:25882481 NA -0.81 -21.07 -0.64 3.01e-75 Urate levels; BRCA cis rs13064411 0.518 rs7637618 chr3:113176122 G/A cg18753928 chr3:113234510 CCDC52 -0.4 -9.05 -0.34 1.73e-18 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs12986413 0.624 rs2108825 chr19:2136515 T/C cg09261902 chr19:2140048 AP3D1 0.41 10.83 0.39 3.16e-25 Height; BRCA cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs7267979 1.000 rs2482931 chr20:25334445 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.53 -0.32 1.1e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836633 0.929 rs4143428 chr21:40030582 G/T cg05519781 chr21:40033154 ERG 0.46 9.83 0.36 2.38e-21 Coronary artery disease; BRCA cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg06784218 chr1:46089804 CCDC17 0.45 10.78 0.39 4.99e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10463316 0.855 rs13359064 chr5:150765575 G/A cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.39e-16 Metabolite levels (Pyroglutamine); BRCA trans rs17685 0.753 rs1574107 chr7:75685047 A/C cg19862616 chr7:65841803 NCRNA00174 0.86 28.56 0.75 2.88e-116 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2387326 0.717 rs10829341 chr10:129944226 G/A cg16087940 chr10:129947807 NA -0.45 -8.01 -0.3 5.47e-15 Select biomarker traits; BRCA cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg19274703 chr22:41806451 NA 0.38 9.23 0.34 3.87e-19 Vitiligo; BRCA cis rs7560272 0.501 rs12713798 chr2:73986421 C/T cg20560298 chr2:73613845 ALMS1 0.34 8.85 0.33 8.36e-18 Schizophrenia; BRCA cis rs3796619 1.000 rs11247973 chr4:1094314 G/A cg27284194 chr4:1044797 NA 0.42 9.13 0.34 8.92e-19 Recombination rate (males); BRCA cis rs7829975 0.535 rs17683510 chr8:8500724 A/G cg06636001 chr8:8085503 FLJ10661 0.47 10.16 0.37 1.43e-22 Mood instability; BRCA cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg13010199 chr12:38710504 ALG10B 0.45 9.3 0.35 2.21e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs9640161 0.789 rs1464752 chr7:150021284 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.57 -14.06 -0.49 2.66e-39 Blood protein levels;Circulating chemerin levels; BRCA cis rs7552404 0.556 rs12124417 chr1:76353294 T/C cg10523679 chr1:76189770 ACADM 0.43 8.01 0.3 5.31e-15 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs72772090 0.908 rs76539796 chr5:96038675 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.54 -11.81 -0.42 3.04e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs8073060 0.586 rs225292 chr17:33926383 G/A cg19694781 chr19:47549865 TMEM160 -0.81 -16.35 -0.54 1.93e-50 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9486719 0.947 rs12213375 chr6:96902134 A/G cg06623918 chr6:96969491 KIAA0776 -0.72 -12.75 -0.45 2.44e-33 Migraine;Coronary artery disease; BRCA cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg22800045 chr5:56110881 MAP3K1 0.46 9.1 0.34 1.14e-18 Initial pursuit acceleration; BRCA cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg11502198 chr6:26597334 ABT1 0.58 12.69 0.45 4.54e-33 Intelligence (multi-trait analysis); BRCA trans rs634534 0.561 rs14157 chr11:65769780 T/G cg17712092 chr4:129076599 LARP1B 0.56 13.49 0.47 1.07e-36 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg20203395 chr5:56204925 C5orf35 -0.5 -10.45 -0.38 1.09e-23 Initial pursuit acceleration; BRCA cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs7646881 1.000 rs73015649 chr3:158450298 C/G cg19483011 chr3:158453295 NA -0.5 -9.38 -0.35 1.09e-19 Tetralogy of Fallot; BRCA cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg24110177 chr3:50126178 RBM5 0.53 14.86 0.51 3.88e-43 Body mass index; BRCA cis rs7666738 0.830 rs7664340 chr4:99037820 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.57 0.55 1.49e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs727479 0.543 rs4324076 chr15:51510868 A/C cg19946085 chr15:51559439 CYP19A1 -0.29 -8.03 -0.3 4.64e-15 Estradiol levels; BRCA cis rs2832191 0.720 rs7277028 chr21:30494604 T/C cg08807101 chr21:30365312 RNF160 -0.6 -14.78 -0.5 1.03e-42 Dental caries; BRCA cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg08754478 chr10:133766260 PPP2R2D -0.68 -14.11 -0.49 1.44e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7914558 0.966 rs12571568 chr10:104891396 C/G cg04362960 chr10:104952993 NT5C2 0.44 10.8 0.39 4.26e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2243480 1.000 rs78803505 chr7:65382572 A/T cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs9649213 0.519 rs3735258 chr7:97866291 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.51 -12.88 -0.45 6.4e-34 Prostate cancer (SNP x SNP interaction); BRCA cis rs210142 1.000 rs210142 chr6:33546837 T/C cg07679836 chr6:33548423 BAK1 0.65 13.86 0.48 2.11e-38 Platelet count;Plateletcrit;Chronic lymphocytic leukemia; BRCA cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.72 0.36 6.67e-21 Bipolar disorder; BRCA cis rs6429082 0.585 rs7524848 chr1:235711688 G/C cg26050004 chr1:235667680 B3GALNT2 -0.54 -12.65 -0.45 7.1e-33 Adiposity; BRCA cis rs950776 0.616 rs647041 chr15:78880481 T/C cg06917634 chr15:78832804 PSMA4 -0.6 -13.27 -0.46 1.15e-35 Sudden cardiac arrest; BRCA cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg01017244 chr2:74357527 NA 0.56 13.4 0.47 2.77e-36 Gestational age at birth (maternal effect); BRCA cis rs8017423 0.647 rs1958346 chr14:90824011 G/T cg04374321 chr14:90722782 PSMC1 -0.49 -11.86 -0.42 1.75e-29 Mortality in heart failure; BRCA cis rs4566357 0.615 rs2894626 chr2:227916039 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -9.53 -0.35 3.26e-20 Coronary artery disease; BRCA cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg06238570 chr21:40685208 BRWD1 -0.43 -8.52 -0.32 1.18e-16 Cognitive function; BRCA cis rs853679 0.517 rs9468297 chr6:28118874 G/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.95 -0.3 8.4e-15 Depression; BRCA cis rs7633770 0.710 rs34820891 chr3:46698059 A/G cg11219411 chr3:46661640 NA -0.45 -10.6 -0.39 2.6e-24 Coronary artery disease; BRCA cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg23711669 chr6:146136114 FBXO30 -0.77 -17.93 -0.58 1.6e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg10556349 chr10:835070 NA 0.74 9.99 0.37 6.24e-22 Eosinophil percentage of granulocytes; BRCA cis rs17601876 0.814 rs8038715 chr15:51561120 T/A cg19946085 chr15:51559439 CYP19A1 -0.38 -11.48 -0.41 7.14e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg10523679 chr1:76189770 ACADM -0.45 -8.23 -0.31 1.04e-15 Daytime sleep phenotypes; BRCA cis rs752010 1.000 rs4999015 chr1:42093547 G/A cg06885757 chr1:42089581 HIVEP3 0.27 9.66 0.36 1.11e-20 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7100689 0.577 rs7901663 chr10:82153488 C/G cg01528321 chr10:82214614 TSPAN14 0.85 19.04 0.6 2.32e-64 Post bronchodilator FEV1; BRCA cis rs12612619 0.732 rs6547355 chr2:27210205 G/A cg00617064 chr2:27272375 NA -0.32 -8.49 -0.32 1.45e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs16976116 0.901 rs28714578 chr15:55491121 G/A cg11288833 chr15:55489084 RSL24D1 0.47 10.58 0.39 3.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg01181863 chr3:195395398 SDHAP2 -0.46 -8.08 -0.3 3.27e-15 Pancreatic cancer; BRCA cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.81 -0.33 1.22e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg12373951 chr3:133503437 NA 0.34 8.1 0.31 2.73e-15 Iron status biomarkers; BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg01262667 chr19:19385393 TM6SF2 0.42 10.67 0.39 1.49e-24 Tonsillectomy; BRCA cis rs4919694 1.000 rs7083328 chr10:104769268 G/A cg04362960 chr10:104952993 NT5C2 0.94 14.64 0.5 4.47e-42 Arsenic metabolism; BRCA cis rs887829 0.641 rs10197460 chr2:234589190 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.36 -0.31 3.96e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs7666738 0.546 rs10007424 chr4:98885450 C/T cg05340658 chr4:99064831 C4orf37 0.55 10.86 0.39 2.45e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8072100 0.935 rs4793978 chr17:45698175 G/A cg08085267 chr17:45401833 C17orf57 0.59 12.38 0.44 1.08e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs2580764 0.503 rs2972097 chr2:55267545 T/C cg09592903 chr2:55203963 RTN4 0.3 7.82 0.3 2.11e-14 Mean platelet volume; BRCA cis rs60843830 1.000 rs9213 chr2:218386 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.7 13.85 0.48 2.52e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg12641515 chr19:46296257 DMWD -0.52 -11.46 -0.41 8.91e-28 Coronary artery disease; BRCA cis rs12760731 0.720 rs12048790 chr1:178407906 T/C cg00404053 chr1:178313656 RASAL2 0.61 7.92 0.3 1.09e-14 Obesity-related traits; BRCA cis rs1580019 0.961 rs1580022 chr7:32497712 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.51 0.32 1.26e-16 Cognitive ability; BRCA cis rs7666738 0.800 rs11941885 chr4:99072921 A/C cg05340658 chr4:99064831 C4orf37 0.7 17.34 0.57 1.69e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg12444411 chr7:2802554 GNA12 0.31 7.92 0.3 1.08e-14 Height; BRCA cis rs75804782 0.641 rs56396448 chr2:239335234 C/T cg18131467 chr2:239335373 ASB1 -0.61 -7.9 -0.3 1.27e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs2204008 0.542 rs34770471 chr12:38009613 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.72e-22 Bladder cancer; BRCA cis rs12618769 0.597 rs3769716 chr2:99133305 G/A cg10123293 chr2:99228465 UNC50 0.42 8.1 0.31 2.81e-15 Bipolar disorder; BRCA cis rs2555155 0.602 rs2555143 chr11:6541580 G/T cg24637308 chr11:6592297 DNHD1 -0.34 -7.82 -0.3 2.14e-14 DNA methylation (variation); BRCA cis rs4285028 0.948 rs34566912 chr3:121679626 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.8 -0.39 4.29e-25 Multiple sclerosis; BRCA cis rs861020 0.771 rs126280 chr1:210019824 A/G cg05527609 chr1:210001259 C1orf107 0.73 18.16 0.58 9.37e-60 Orofacial clefts; BRCA cis rs2153535 0.584 rs62395678 chr6:8371689 C/T cg23788917 chr6:8435910 SLC35B3 -0.43 -9.27 -0.34 2.91e-19 Motion sickness; BRCA cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg06494592 chr3:125709126 NA -0.54 -8.33 -0.31 4.81e-16 Blood pressure (smoking interaction); BRCA cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 9.48 0.35 4.93e-20 Height; BRCA cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.84 -0.33 9.58e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs9473147 0.516 rs13212790 chr6:47576367 T/C cg12968598 chr6:47444699 CD2AP 0.44 9.62 0.36 1.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03934478 chr11:495069 RNH1 0.81 11.62 0.42 1.82e-28 Body mass index; BRCA trans rs208520 0.690 rs12202913 chr6:66734198 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.74 0.63 1.96e-73 Exhaled nitric oxide output; BRCA cis rs10791097 0.720 rs6590517 chr11:130733505 C/T cg12179176 chr11:130786555 SNX19 0.67 16.32 0.54 2.53e-50 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.67 -0.39 1.37e-24 Gut microbiome composition (summer); BRCA cis rs6558530 0.799 rs62477060 chr8:1706498 A/T cg19131313 chr8:1704013 NA -0.36 -7.87 -0.3 1.55e-14 Systolic blood pressure; BRCA cis rs7945718 0.839 rs2033908 chr11:12838286 G/T cg25843174 chr11:12811716 TEAD1 0.21 8.09 0.3 3.1e-15 Educational attainment (years of education); BRCA cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg27211696 chr2:191398769 TMEM194B 0.48 7.92 0.3 1.02e-14 Diastolic blood pressure; BRCA cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg26248373 chr2:1572462 NA 0.5 9.72 0.36 6.33e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.3 0.41 3.86e-27 Electroencephalogram traits; BRCA cis rs2580764 0.515 rs7570629 chr2:55255935 A/T cg09592903 chr2:55203963 RTN4 -0.39 -9.98 -0.37 6.9e-22 Mean platelet volume; BRCA cis rs2070488 0.965 rs7433277 chr3:38529818 C/T cg24069376 chr3:38537580 EXOG 0.43 12.31 0.44 2.04e-31 Electrocardiographic conduction measures; BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg14004847 chr7:1930337 MAD1L1 -0.43 -8.18 -0.31 1.58e-15 Bipolar disorder and schizophrenia; BRCA cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg07414643 chr4:187882934 NA 0.28 9.72 0.36 6.36e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg17330251 chr7:94953956 PON1 -0.4 -8.4 -0.32 2.93e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7493 1.000 rs12155103 chr7:95037131 G/A cg19678392 chr7:94953810 PON1 -0.42 -9.11 -0.34 1.03e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg22349387 chr12:9600060 DDX12 -0.39 -9.03 -0.34 2.05e-18 Breast size; BRCA cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg14403583 chr14:105418241 AHNAK2 -0.38 -8.94 -0.33 4.19e-18 Rheumatoid arthritis; BRCA cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg20607798 chr8:58055168 NA 0.46 8.04 0.3 4.35e-15 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg03433033 chr1:76189801 ACADM 0.88 23.02 0.67 7.52e-86 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1401999 0.898 rs9876143 chr3:183731362 C/G cg20387954 chr3:183756860 HTR3D 0.46 10.34 0.38 2.8e-23 Anterior chamber depth; BRCA cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.24 0.41 6.88e-27 Bipolar disorder; BRCA cis rs17095355 1.000 rs12267714 chr10:111722052 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.8 -0.36 3.16e-21 Biliary atresia; BRCA cis rs507080 0.922 rs625513 chr11:118555719 A/C cg08498647 chr11:118550644 TREH -0.38 -8.14 -0.31 2.1e-15 Serum metabolite levels; BRCA cis rs9399137 0.507 rs7748708 chr6:135275142 G/A cg24558204 chr6:135376177 HBS1L 0.54 14.97 0.51 1.19e-43 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg07636037 chr3:49044803 WDR6 0.4 8.2 0.31 1.33e-15 Resting heart rate; BRCA cis rs6582630 0.538 rs12304844 chr12:38335870 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.45 -0.35 6.24e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.81 0.42 3.01e-29 Personality dimensions; BRCA cis rs2421770 0.530 rs3901811 chr11:35365675 C/T cg13971030 chr11:35366721 SLC1A2 -0.45 -10.12 -0.37 1.94e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg14983838 chr19:29218262 NA 0.53 8.87 0.33 7.27e-18 Methadone dose in opioid dependence; BRCA cis rs4363385 0.658 rs426147 chr1:153045011 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.04 -0.3 4.26e-15 Inflammatory skin disease; BRCA cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg18876405 chr7:65276391 NA -0.5 -11.15 -0.4 1.6e-26 Aortic root size; BRCA cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.61e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg25174290 chr11:3078921 CARS -0.3 -7.87 -0.3 1.58e-14 Calcium levels; BRCA cis rs17270561 0.666 rs17320090 chr6:25720215 C/G cg16482183 chr6:26056742 HIST1H1C 0.43 8.46 0.32 1.89e-16 Iron status biomarkers; BRCA cis rs35306767 0.903 rs11816064 chr10:931176 A/C cg20503657 chr10:835505 NA 1.05 18.77 0.6 5.82e-63 Eosinophil percentage of granulocytes; BRCA trans rs8002861 0.870 rs4942254 chr13:44451820 C/T cg17145862 chr1:211918768 LPGAT1 0.63 16.12 0.54 2.61e-49 Leprosy; BRCA cis rs1691799 0.899 rs1168318 chr12:66745269 A/G cg16791601 chr12:66731901 HELB 0.64 17.63 0.57 5.82e-57 White blood cell count (basophil); BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg24549020 chr5:56110836 MAP3K1 0.64 12.98 0.46 2.41e-34 Initial pursuit acceleration; BRCA cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA trans rs7613875 0.578 rs2526749 chr3:50076734 A/G cg21659725 chr3:3221576 CRBN -0.35 -8.7 -0.33 2.74e-17 Body mass index; BRCA cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg18904891 chr8:8559673 CLDN23 0.65 12.97 0.46 2.56e-34 Obesity-related traits; BRCA cis rs1707322 0.964 rs6675259 chr1:46502295 G/A cg06784218 chr1:46089804 CCDC17 -0.48 -11.43 -0.41 1.2e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11958404 0.932 rs61478293 chr5:157426299 G/A cg05962755 chr5:157440814 NA 0.49 9.67 0.36 1.02e-20 IgG glycosylation; BRCA trans rs7824557 0.767 rs28507159 chr8:11166076 C/T cg06636001 chr8:8085503 FLJ10661 0.53 10.03 0.37 4.55e-22 Retinal vascular caliber; BRCA cis rs6910061 0.830 rs35281611 chr6:11103232 G/T cg27233058 chr6:11094804 LOC221710 0.5 8.32 0.31 5.21e-16 Diabetic kidney disease; BRCA cis rs2463822 0.920 rs28678254 chr11:62151875 G/C cg06239285 chr11:62104954 ASRGL1 -0.64 -9.24 -0.34 3.66e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg02734326 chr4:10020555 SLC2A9 0.39 8.48 0.32 1.61e-16 Bone mineral density; BRCA cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.28 -0.44 2.95e-31 Bipolar disorder; BRCA cis rs870825 0.587 rs6826883 chr4:185616167 A/C cg04058563 chr4:185651563 MLF1IP 0.78 17.17 0.56 1.32e-54 Blood protein levels; BRCA cis rs6714710 0.603 rs1470483 chr2:98393894 C/T cg26665480 chr2:98280029 ACTR1B 0.66 14.7 0.5 2.44e-42 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg11822812 chr5:140052017 DND1 -0.29 -7.86 -0.3 1.67e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2806561 0.734 rs1952527 chr1:23400969 T/C cg12483005 chr1:23474871 LUZP1 0.44 9.77 0.36 4.13e-21 Height; BRCA cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg05283184 chr6:79620031 NA -0.43 -10.88 -0.4 2.01e-25 Intelligence (multi-trait analysis); BRCA cis rs881375 0.967 rs3761849 chr9:123690957 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.33 0.41 3.18e-27 Rheumatoid arthritis; BRCA cis rs17095355 1.000 rs57440982 chr10:111735772 G/A cg00817464 chr10:111662876 XPNPEP1 -0.37 -9.19 -0.34 5.56e-19 Biliary atresia; BRCA cis rs7412746 0.553 rs59337856 chr1:150746406 G/T cg18016565 chr1:150552671 MCL1 0.34 7.88 0.3 1.39e-14 Melanoma; BRCA cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg05340658 chr4:99064831 C4orf37 0.7 17.48 0.57 3.14e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.741 rs10036829 chr5:93309897 G/C cg21475434 chr5:93447410 FAM172A 0.66 8.48 0.32 1.51e-16 Diabetic retinopathy; BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg04166393 chr7:2884313 GNA12 0.48 8.92 0.33 5.02e-18 Height; BRCA trans rs11098499 0.954 rs59394118 chr4:120295551 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.56 0.42 3.34e-28 Corneal astigmatism; BRCA cis rs11711311 1.000 rs9865435 chr3:113450046 G/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg23711669 chr6:146136114 FBXO30 -0.79 -18.4 -0.59 5.66e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg23649088 chr2:200775458 C2orf69 -0.58 -8.76 -0.33 1.81e-17 Schizophrenia; BRCA trans rs8002861 0.713 rs7339417 chr13:44413496 A/T cg17145862 chr1:211918768 LPGAT1 0.47 10.61 0.39 2.37e-24 Leprosy; BRCA cis rs9467773 0.967 rs9295694 chr6:26512994 A/T cg09904177 chr6:26538194 HMGN4 0.56 18.45 0.59 3.08e-61 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg06784218 chr1:46089804 CCDC17 0.46 10.91 0.4 1.6e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4074536 0.574 rs4564143 chr1:116293963 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.44 -0.32 2.12e-16 QRS duration; BRCA cis rs3784262 0.669 rs4646559 chr15:58354258 A/G cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.41 -0.38 1.52e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6964587 1.000 rs7791138 chr7:91686789 A/G cg17063962 chr7:91808500 NA 0.58 13.75 0.48 7.25e-38 Breast cancer; BRCA cis rs7599312 0.534 rs2128321 chr2:213405276 G/T cg20637307 chr2:213403960 ERBB4 0.74 21.48 0.65 1.94e-77 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs7903847 0.642 rs2275090 chr10:99148151 A/G cg08345082 chr10:99160200 RRP12 -0.29 -8.57 -0.32 7.87e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg11247378 chr22:39784982 NA 0.66 16.11 0.54 2.9e-49 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs7615952 0.515 rs4441610 chr3:125681307 C/G cg05084668 chr3:125655381 ALG1L -0.61 -11.85 -0.42 2.09e-29 Blood pressure (smoking interaction); BRCA cis rs478304 0.934 rs474483 chr11:65520060 T/G cg08755490 chr11:65554678 OVOL1 0.55 11.45 0.41 9.95e-28 Acne (severe); BRCA cis rs875971 0.540 rs781152 chr7:65479572 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 8.9 0.33 5.6e-18 Aortic root size; BRCA cis rs849141 1.000 rs849141 chr7:28185091 C/T cg22892036 chr7:28189139 JAZF1 -0.47 -8.48 -0.32 1.58e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg22920501 chr2:26401640 FAM59B 0.72 12.27 0.44 3.22e-31 Gut microbiome composition (summer); BRCA cis rs7766436 0.610 rs13195654 chr6:22601416 C/G cg13666174 chr6:22585274 NA -0.38 -8.87 -0.33 7.19e-18 Coronary artery disease; BRCA cis rs10046574 0.831 rs77263000 chr7:135099419 C/T cg27474649 chr7:135195673 CNOT4 0.58 8.33 0.31 5.1e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs600806 0.850 rs10776807 chr1:109956156 A/G cg20591472 chr1:110008990 SYPL2 -0.34 -8.59 -0.32 6.49e-17 Intelligence (multi-trait analysis); BRCA cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg06636001 chr8:8085503 FLJ10661 0.68 15.42 0.52 7.42e-46 Mood instability; BRCA trans rs6089829 0.962 rs1060490 chr20:61665871 A/G cg17470723 chr8:74884337 TCEB1 0.4 8.66 0.32 3.82e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -17.61 -0.57 7.09e-57 Extrinsic epigenetic age acceleration; BRCA cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11644478 chr21:40555479 PSMG1 0.82 18.54 0.59 1.05e-61 Cognitive function; BRCA cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg17892150 chr10:133769511 PPP2R2D -0.72 -15.46 -0.52 5.12e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg12756686 chr19:29218302 NA 0.56 11.64 0.42 1.5e-28 Methadone dose in opioid dependence; BRCA cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg27398817 chr8:82754497 SNX16 -0.37 -8.55 -0.32 8.8e-17 Diastolic blood pressure; BRCA cis rs7666738 0.830 rs10010698 chr4:98981594 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg09436375 chr6:42928200 GNMT -0.3 -10.99 -0.4 7.31e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs847577 0.748 rs940432 chr7:97716483 G/A cg24562669 chr7:97807699 LMTK2 0.62 18.68 0.59 1.78e-62 Breast cancer; BRCA cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg11764359 chr7:65958608 NA 0.75 16.95 0.56 1.7e-53 Aortic root size; BRCA trans rs11098499 0.780 rs7680914 chr4:120563053 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.6 0.42 2.35e-28 Corneal astigmatism; BRCA cis rs6546886 0.957 rs11886928 chr2:74258529 T/G cg14702570 chr2:74259524 NA -0.32 -8.21 -0.31 1.22e-15 Dialysis-related mortality; BRCA cis rs10751667 0.961 rs10902263 chr11:992691 A/C ch.11.42038R chr11:967971 AP2A2 -0.51 -15.61 -0.53 9.03e-47 Alzheimer's disease (late onset); BRCA cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg18270830 chr10:32634957 EPC1 0.58 10.06 0.37 3.34e-22 Sexual dysfunction (female); BRCA cis rs1401999 0.934 rs1132776 chr3:183696402 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.28 0.38 4.88e-23 Anterior chamber depth; BRCA cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -10.18 -0.37 1.21e-22 Personality dimensions; BRCA cis rs10751667 0.961 rs6597971 chr11:928598 T/A ch.11.42038R chr11:967971 AP2A2 0.55 17.89 0.58 2.6e-58 Alzheimer's disease (late onset); BRCA cis rs1538970 0.962 rs2185549 chr1:45814103 C/T cg05343316 chr1:45956843 TESK2 -0.55 -11.03 -0.4 4.98e-26 Platelet count; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg08470875 chr2:26401718 FAM59B 0.77 12.02 0.43 3.96e-30 Gut microbiome composition (summer); BRCA cis rs8028182 0.636 rs11636199 chr15:75825337 A/G cg20655648 chr15:75932815 IMP3 0.4 7.88 0.3 1.43e-14 Sudden cardiac arrest; BRCA cis rs2235642 0.533 rs9922661 chr16:1605163 C/A cg03034668 chr16:1723424 CRAMP1L -0.5 -10.75 -0.39 6.87e-25 Coronary artery disease; BRCA cis rs9837602 0.507 rs793455 chr3:99526135 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.65 -14.76 -0.5 1.2e-42 Breast cancer; BRCA cis rs72772090 0.539 rs72773923 chr5:96117579 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2882667 0.654 rs700626 chr5:138117938 A/G cg04439458 chr5:138467593 SIL1 0.33 8.12 0.31 2.36e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7729447 0.776 rs17540155 chr5:32694033 C/T cg16267343 chr5:32710456 NPR3 0.44 9.06 0.34 1.6e-18 Blood pressure; BRCA cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg07606381 chr6:8435919 SLC35B3 -0.64 -13.92 -0.48 1.21e-38 Motion sickness; BRCA cis rs4663969 0.541 rs11902131 chr2:234594269 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.38 -0.31 3.32e-16 Total bilirubin levels in HIV-1 infection; BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg08470875 chr2:26401718 FAM59B -0.51 -8.29 -0.31 6.69e-16 Gut microbiome composition (summer); BRCA cis rs4853036 1.000 rs35084691 chr2:70094137 C/T cg02498382 chr2:70120550 SNRNP27 -0.5 -9.14 -0.34 8.14e-19 Colorectal or endometrial cancer; BRCA cis rs2832191 0.716 rs2297252 chr21:30377104 G/A cg08807101 chr21:30365312 RNF160 0.77 20.54 0.63 2.13e-72 Dental caries; BRCA cis rs490234 0.812 rs17259739 chr9:128456639 C/T cg14078157 chr9:128172775 NA 0.41 9.08 0.34 1.31e-18 Mean arterial pressure; BRCA trans rs12310956 0.532 rs7979535 chr12:33947450 A/C cg13010199 chr12:38710504 ALG10B -0.48 -9.4 -0.35 9.48e-20 Morning vs. evening chronotype; BRCA cis rs7512552 0.809 rs696618 chr1:150376139 T/G cg15654264 chr1:150340011 RPRD2 0.4 8.77 0.33 1.66e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs2070488 0.775 rs6599208 chr3:38558104 A/C cg24069376 chr3:38537580 EXOG -0.34 -9.45 -0.35 6.53e-20 Electrocardiographic conduction measures; BRCA cis rs7829975 0.509 rs7838674 chr8:8797073 A/T cg06636001 chr8:8085503 FLJ10661 -0.54 -11.67 -0.42 1.13e-28 Mood instability; BRCA cis rs7103648 0.838 rs11039244 chr11:47466442 G/A cg20307385 chr11:47447363 PSMC3 0.82 21.33 0.64 1.28e-76 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs910316 0.763 rs175057 chr14:75489632 C/T cg11812906 chr14:75593930 NEK9 -0.59 -12.9 -0.45 5.39e-34 Height; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.56 -9.59 -0.35 1.95e-20 Gut microbiome composition (summer); BRCA cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.23 -0.38 7.48e-23 Psoriasis; BRCA cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg19784903 chr17:45786737 TBKBP1 0.34 8.16 0.31 1.72e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4409675 0.576 rs2749110 chr1:28235010 T/C cg23691781 chr1:28212827 C1orf38 0.32 10.61 0.39 2.47e-24 Corneal astigmatism; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.62 -0.36 1.51e-20 Total body bone mineral density; BRCA cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.91 -0.3 1.16e-14 Axial length; BRCA cis rs11098499 0.789 rs10212719 chr4:120254437 T/C cg09307838 chr4:120376055 NA 0.63 13.62 0.47 2.93e-37 Corneal astigmatism; BRCA cis rs2075371 0.871 rs418135 chr7:133949898 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.09 0.37 2.62e-22 Mean platelet volume; BRCA cis rs2880765 0.835 rs4843063 chr15:86048748 G/T cg10818794 chr15:86012489 AKAP13 -0.31 -8.58 -0.32 7.38e-17 Coronary artery disease; BRCA trans rs208520 0.690 rs207119 chr6:66786408 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg00080972 chr5:178986291 RUFY1 -0.47 -12.77 -0.45 1.99e-33 Lung cancer; BRCA cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.17 -0.31 1.59e-15 Bipolar disorder; BRCA cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg21770322 chr7:97807741 LMTK2 0.45 11.74 0.42 5.76e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7654585 1.000 rs4692025 chr4:25949759 A/C cg10409131 chr4:25915609 C4orf52 -0.37 -8.23 -0.31 1.08e-15 Obesity-related traits; BRCA cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg13010199 chr12:38710504 ALG10B 0.52 10.55 0.39 4.1e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs2486288 0.656 rs6493145 chr15:45573862 G/T cg15395560 chr15:45543142 SLC28A2 0.29 7.99 0.3 6.43e-15 Glomerular filtration rate; BRCA cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg17971929 chr21:40555470 PSMG1 0.7 14.67 0.5 3.41e-42 Cognitive function; BRCA cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg21132104 chr15:45694354 SPATA5L1 0.75 16.89 0.56 3.4e-53 Homoarginine levels; BRCA cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg03433033 chr1:76189801 ACADM -0.59 -11.81 -0.42 2.98e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg23583168 chr7:148888333 NA -0.79 -18.7 -0.59 1.48e-62 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7666738 0.822 rs28367231 chr4:98845726 G/T cg05340658 chr4:99064831 C4orf37 0.61 14.63 0.5 5.37e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs17620991 1.000 rs67648979 chr7:40851735 T/C cg05119115 chr7:40866195 C7orf10 -0.56 -8.67 -0.32 3.66e-17 Alcohol dependence; BRCA cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg12386194 chr3:101231763 SENP7 0.46 9.65 0.36 1.13e-20 Colorectal cancer; BRCA cis rs2859741 0.546 rs3845491 chr1:37497521 C/T cg09363841 chr1:37513479 NA -0.53 -11.53 -0.41 4.55e-28 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg10862848 chr6:42927986 GNMT -0.34 -14.5 -0.5 2.09e-41 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg27170947 chr2:26402098 FAM59B -0.64 -11.37 -0.41 2.02e-27 Gut microbiome composition (summer); BRCA cis rs9341808 0.935 rs942381 chr6:80880150 T/G cg08355045 chr6:80787529 NA 0.33 8.5 0.32 1.36e-16 Sitting height ratio; BRCA cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg06784218 chr1:46089804 CCDC17 0.46 10.9 0.4 1.78e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg22800045 chr5:56110881 MAP3K1 0.65 12.22 0.44 5.19e-31 Initial pursuit acceleration; BRCA trans rs1005277 0.557 rs2983338 chr10:38550734 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.82 -0.45 1.15e-33 Extrinsic epigenetic age acceleration; BRCA cis rs3784262 0.542 rs2899611 chr15:58327347 A/C cg12031962 chr15:58353849 ALDH1A2 -0.4 -10.55 -0.39 4.24e-24 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs208520 0.661 rs7766144 chr6:66827795 C/T cg07460842 chr6:66804631 NA -1.02 -19.97 -0.62 2.53e-69 Exhaled nitric oxide output; BRCA cis rs2075371 0.966 rs2544214 chr7:133985736 G/A cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.95e-23 Mean platelet volume; BRCA cis rs4689388 0.890 rs4689398 chr4:6302199 C/T cg00701064 chr4:6280414 WFS1 0.69 19.26 0.61 1.61e-65 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10056811 0.538 rs4703645 chr5:74361140 A/G cg19683494 chr5:74908142 NA 0.58 8.76 0.33 1.69e-17 Coronary artery disease; BRCA cis rs736408 0.522 rs998909 chr3:52805093 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.02 0.43 3.79e-30 Bipolar disorder; BRCA cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg16743903 chr16:89593216 SPG7 -0.31 -7.81 -0.3 2.35e-14 Multiple myeloma (IgH translocation); BRCA trans rs61931739 0.513 rs7956626 chr12:33901640 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.9 0.36 1.4e-21 Morning vs. evening chronotype; BRCA cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -8.56 -0.32 8.55e-17 Alzheimer's disease (late onset); BRCA cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg04450456 chr4:17643702 FAM184B -0.38 -11.24 -0.41 7.26e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12973672 1.000 rs12975284 chr19:35770962 G/C cg12095397 chr19:35769544 USF2 0.38 8.38 0.31 3.28e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1552244 0.572 rs59074548 chr3:10164347 G/C cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs73086581 1.000 rs73086581 chr20:3977325 T/C cg02187196 chr20:3869020 PANK2 0.53 9.16 0.34 6.95e-19 Response to antidepressants in depression; BRCA cis rs1949733 0.543 rs62287446 chr4:8535988 G/A cg11789530 chr4:8429930 ACOX3 -0.5 -11.75 -0.42 5.52e-29 Response to antineoplastic agents; BRCA cis rs17095355 1.000 rs75079039 chr10:111745121 T/C cg00817464 chr10:111662876 XPNPEP1 -0.43 -9.1 -0.34 1.16e-18 Biliary atresia; BRCA cis rs4074536 0.574 rs9887853 chr1:116288027 G/T cg21648376 chr1:116311395 CASQ2 -0.49 -8.68 -0.32 3.25e-17 QRS duration; BRCA cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 13.89 0.48 1.53e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs250677 0.522 rs4562031 chr5:148368451 A/G cg12140854 chr5:148520817 ABLIM3 0.39 7.89 0.3 1.33e-14 Breast cancer; BRCA cis rs4664304 0.620 rs1828480 chr2:160720384 G/A cg18514922 chr2:160761262 LY75 0.33 7.89 0.3 1.29e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg10845886 chr2:3471009 TTC15 -0.55 -12.27 -0.44 3.1e-31 Neurofibrillary tangles; BRCA cis rs7246657 0.722 rs2972437 chr19:38210511 G/T cg18154014 chr19:37997991 ZNF793 0.49 9.41 0.35 8.47e-20 Coronary artery calcification; BRCA cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg24675658 chr1:53192096 ZYG11B 0.63 15.14 0.51 1.84e-44 Monocyte count; BRCA cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.68 -15.51 -0.52 2.8600000000000002e-46 Multiple sclerosis; BRCA cis rs912330 0.825 rs7317938 chr13:99234361 C/T cg07423050 chr13:99094983 FARP1 -0.34 -7.99 -0.3 6.31e-15 Alzheimer's disease; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg07308232 chr7:1071921 C7orf50 -0.5 -10.56 -0.39 4.01e-24 Longevity;Endometriosis; BRCA cis rs782590 0.748 rs782634 chr2:55897700 T/C cg18811423 chr2:55921094 PNPT1 0.74 23.24 0.68 4.43e-87 Metabolic syndrome; BRCA cis rs4730250 0.707 rs78472146 chr7:106967491 C/A cg02696742 chr7:106810147 HBP1 -0.54 -8.74 -0.33 2.03e-17 Osteoarthritis; BRCA cis rs8017423 0.967 rs11624725 chr14:90713609 G/T cg14092571 chr14:90743983 NA 0.34 8.22 0.31 1.11e-15 Mortality in heart failure; BRCA trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg15704280 chr7:45808275 SEPT13 0.63 11.24 0.41 6.97e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11229555 0.645 rs11229436 chr11:58186009 G/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs11955398 0.585 rs2100584 chr5:60021487 C/G cg02684056 chr5:59996105 DEPDC1B -0.38 -9.13 -0.34 8.56e-19 Intelligence (multi-trait analysis); BRCA cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg20891558 chr2:74357851 NA 0.51 11.99 0.43 5.06e-30 Gestational age at birth (maternal effect); BRCA cis rs7246657 0.943 rs7258692 chr19:37818829 C/A cg23950597 chr19:37808831 NA -0.65 -11.6 -0.42 2.38e-28 Coronary artery calcification; BRCA cis rs528301 0.868 rs518853 chr2:45141218 A/G cg02372786 chr2:45167549 SIX3 0.43 10.47 0.38 8.73e-24 Alcohol and nicotine co-dependence; BRCA cis rs35110281 0.807 rs6518301 chr21:45016818 T/C cg01579765 chr21:45077557 HSF2BP -0.4 -10.86 -0.39 2.49e-25 Mean corpuscular volume; BRCA cis rs13095912 0.752 rs7613002 chr3:185353235 T/C cg11274856 chr3:185301563 NA 0.51 11.85 0.42 1.96e-29 Systolic blood pressure; BRCA trans rs11098499 0.863 rs1383533 chr4:120434576 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.31 0.44 2.14e-31 Corneal astigmatism; BRCA cis rs826838 0.935 rs11169511 chr12:39175802 T/C cg26384229 chr12:38710491 ALG10B 0.81 20.39 0.63 1.52e-71 Heart rate; BRCA cis rs6545883 0.859 rs2694644 chr2:61604856 A/T cg15711740 chr2:61764176 XPO1 0.5 12.06 0.43 2.5e-30 Tuberculosis; BRCA cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg06026331 chr20:60912101 LAMA5 0.63 13.17 0.46 3.09e-35 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs2303745 0.589 rs11882562 chr19:17395055 C/G cg02221750 chr19:17393354 ANKLE1 0.65 12.49 0.44 3.52e-32 Systemic lupus erythematosus; BRCA cis rs7582180 0.614 rs2241809 chr2:101014363 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.81 -0.3 2.3e-14 Intelligence (multi-trait analysis); BRCA cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg18512352 chr11:47633146 NA -0.33 -7.9 -0.3 1.23e-14 Subjective well-being; BRCA cis rs12618769 0.597 rs4599165 chr2:99144483 G/A cg10123293 chr2:99228465 UNC50 0.42 8.1 0.31 2.81e-15 Bipolar disorder; BRCA cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg06064525 chr11:970664 AP2A2 0.48 16.2 0.54 1.02e-49 Alzheimer's disease (late onset); BRCA trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.79 -0.36 3.58e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg12310025 chr6:25882481 NA -0.53 -11.84 -0.42 2.16e-29 Intelligence (multi-trait analysis); BRCA cis rs7949030 1.000 rs7949030 chr11:62394881 A/G cg22862634 chr11:62369728 EML3;MTA2 0.39 9.84 0.36 2.22e-21 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12367572 0.930 rs10880695 chr12:45233261 T/C cg04608330 chr12:45269318 NELL2 -0.61 -12.75 -0.45 2.53e-33 Gut microbiome composition (summer); BRCA cis rs56804039 1.000 rs67180327 chr8:8380754 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -9.19 -0.34 5.42e-19 Cervical cancer; BRCA cis rs7617773 0.780 rs34523942 chr3:48342669 C/T cg11946769 chr3:48343235 NME6 0.64 13.73 0.48 8.98e-38 Coronary artery disease; BRCA cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06481639 chr22:41940642 POLR3H -0.53 -8.77 -0.33 1.64e-17 Vitiligo; BRCA cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg15485101 chr11:133734466 NA 0.41 9.87 0.36 1.7e-21 Childhood ear infection; BRCA cis rs6835098 0.923 rs9997477 chr4:174112543 C/T cg27433088 chr4:174089019 GALNT7 0.31 8.49 0.32 1.45e-16 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg08601574 chr20:25228251 PYGB -0.39 -9.0 -0.34 2.47e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11971779 0.555 rs6950143 chr7:139054418 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg18876405 chr7:65276391 NA 0.62 15.48 0.52 3.7e-46 Aortic root size; BRCA trans rs2204008 0.811 rs11525004 chr12:38333807 T/A cg06521331 chr12:34319734 NA -0.48 -8.66 -0.32 3.93e-17 Bladder cancer; BRCA trans rs7939886 0.920 rs12223248 chr11:55887633 A/C cg15704280 chr7:45808275 SEPT13 0.62 8.02 0.3 5.13e-15 Myopia (pathological); BRCA cis rs897080 0.515 rs1085450 chr2:44650698 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.81 0.33 1.18e-17 Height; BRCA cis rs7100689 0.646 rs9420370 chr10:82073248 C/T cg01528321 chr10:82214614 TSPAN14 0.79 16.62 0.55 8.24e-52 Post bronchodilator FEV1; BRCA cis rs7917772 0.582 rs4919661 chr10:104358403 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11677370 0.561 rs10084170 chr2:3820204 G/C cg17052675 chr2:3827356 NA -0.6 -15.11 -0.51 2.37e-44 Type 2 diabetes; BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg12311346 chr5:56204834 C5orf35 -0.78 -16.17 -0.54 1.4e-49 Initial pursuit acceleration; BRCA cis rs11971779 0.618 rs6943788 chr7:139087697 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg06550200 chr5:1325588 CLPTM1L -0.64 -13.24 -0.46 1.54e-35 Lung cancer; BRCA cis rs1843834 0.755 rs10194591 chr2:225574276 T/A cg22455342 chr2:225449267 CUL3 0.35 8.18 0.31 1.52e-15 IgE levels in asthmatics (D.p. specific); BRCA cis rs61931739 0.517 rs7960878 chr12:34055645 C/A cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.44e-26 Morning vs. evening chronotype; BRCA cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg01689657 chr7:91764605 CYP51A1 0.23 8.08 0.3 3.29e-15 Breast cancer; BRCA cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg13880726 chr7:1868755 MAD1L1 -0.55 -11.3 -0.41 3.87e-27 Bipolar disorder and schizophrenia; BRCA cis rs7584330 0.744 rs10929234 chr2:238380034 C/G cg14458575 chr2:238380390 NA -0.77 -17.57 -0.57 1.1e-56 Prostate cancer; BRCA cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg03517284 chr6:25882590 NA -0.48 -10.03 -0.37 4.53e-22 Intelligence (multi-trait analysis); BRCA cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2204008 0.712 rs12371182 chr12:38321143 A/C cg26384229 chr12:38710491 ALG10B 0.77 17.33 0.57 1.91e-55 Bladder cancer; BRCA trans rs6089829 0.926 rs7273917 chr20:61665975 G/A cg15934090 chr1:100435551 SLC35A3 0.35 8.1 0.31 2.72e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg09177884 chr7:1199841 ZFAND2A -0.38 -8.69 -0.33 3e-17 Longevity;Endometriosis; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00802000 chr16:706648 WDR90 -0.39 -9.34 -0.35 1.56e-19 Height; BRCA trans rs9329221 0.662 rs35472251 chr8:10246669 A/G cg15556689 chr8:8085844 FLJ10661 0.38 9.12 0.34 9.44e-19 Neuroticism; BRCA cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.26e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs899997 0.773 rs12595461 chr15:78969172 T/G cg04896959 chr15:78267971 NA -0.47 -9.57 -0.35 2.2e-20 Coronary artery disease or large artery stroke; BRCA cis rs62380364 0.557 rs663046 chr5:88036486 C/T cg22951263 chr5:87985283 NA -0.38 -10.58 -0.39 3.37e-24 Intelligence (multi-trait analysis); BRCA cis rs7177699 0.557 rs6495335 chr15:79117133 G/T cg00540400 chr15:79124168 NA 0.27 7.81 0.3 2.44e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.04 0.34 1.89e-18 Lymphocyte counts; BRCA cis rs4819052 0.851 rs2255774 chr21:46683851 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.4 7.98 0.3 6.63e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6543140 0.964 rs6761350 chr2:103030776 A/G cg04239558 chr2:103089729 SLC9A4 0.33 9.25 0.34 3.24e-19 Blood protein levels; BRCA cis rs6582630 0.599 rs8189525 chr12:38424982 A/C cg26384229 chr12:38710491 ALG10B 0.45 10.38 0.38 2.04e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs3820928 0.605 rs2228555 chr2:227872995 C/T cg05526886 chr2:227700861 RHBDD1 0.39 7.98 0.3 6.79e-15 Pulmonary function; BRCA cis rs12188164 0.543 rs890972 chr5:462465 C/A cg26850624 chr5:429559 AHRR 0.33 7.88 0.3 1.37e-14 Cystic fibrosis severity; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg12419862 chr22:24373484 LOC391322 -0.65 -14.75 -0.5 1.35e-42 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7618915 0.570 rs11130319 chr3:52755592 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.93 0.37 1.04e-21 Bipolar disorder; BRCA cis rs6088580 0.634 rs3736762 chr20:33037336 C/T cg08999081 chr20:33150536 PIGU 0.47 13.03 0.46 1.35e-34 Glomerular filtration rate (creatinine); BRCA cis rs12477438 0.748 rs6712773 chr2:99585781 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.81 -0.58 6.55e-58 Chronic sinus infection; BRCA cis rs9660992 0.710 rs1668867 chr1:205240251 C/T cg21545522 chr1:205238299 TMCC2 0.38 8.32 0.31 5.18e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg13628971 chr7:2884303 GNA12 0.45 8.98 0.33 2.99e-18 Height; BRCA cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg18876405 chr7:65276391 NA -0.5 -11.53 -0.42 4.39e-28 Aortic root size; BRCA cis rs12497850 0.863 rs4858799 chr3:48728204 G/A cg01304814 chr3:48885189 PRKAR2A 0.56 7.84 0.3 1.89e-14 Parkinson's disease; BRCA cis rs9733 0.791 rs11800059 chr1:150651175 C/T cg13175981 chr1:150552382 MCL1 0.47 10.38 0.38 1.96e-23 Tonsillectomy; BRCA cis rs9443645 0.527 rs12527806 chr6:79507667 A/T cg05283184 chr6:79620031 NA -0.36 -8.36 -0.31 3.87e-16 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.527 rs9343861 chr6:79744868 C/A cg18132916 chr6:79620363 NA -0.42 -8.49 -0.32 1.46e-16 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg26395211 chr5:140044315 WDR55 0.37 8.54 0.32 9.62e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs2531992 0.686 rs2041247 chr16:4032581 A/G cg05927578 chr16:4029543 ADCY9 0.39 8.43 0.32 2.35e-16 Waist circumference; BRCA cis rs6598955 0.671 rs17162105 chr1:26591255 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs250677 0.522 rs7702695 chr5:148402550 T/A cg18129178 chr5:148520854 ABLIM3 -0.55 -10.58 -0.39 3.35e-24 Breast cancer; BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.54 10.42 0.38 1.43e-23 Aortic root size; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg10819733 chr22:24237672 NA 0.3 8.28 0.31 7.11e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9308433 0.529 rs9430131 chr1:214481121 C/A cg06198575 chr1:214491504 SMYD2 0.58 12.67 0.45 5.53e-33 IgG glycosylation; BRCA trans rs1493916 0.748 rs1941684 chr18:31304421 C/G cg27147174 chr7:100797783 AP1S1 -0.42 -8.28 -0.31 6.98e-16 Life satisfaction; BRCA cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg16586182 chr3:47516702 SCAP -0.56 -12.63 -0.45 8.74e-33 Colorectal cancer; BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg05793240 chr7:2802953 GNA12 -0.32 -8.07 -0.3 3.38e-15 Height; BRCA cis rs10501293 0.667 rs993904 chr11:42992769 G/T cg03447554 chr11:43094025 NA 0.42 7.97 0.3 7.27e-15 Cognitive performance; BRCA trans rs9329221 0.638 rs7460436 chr8:10254322 C/T cg06636001 chr8:8085503 FLJ10661 0.48 9.15 0.34 7.59e-19 Neuroticism; BRCA cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg06808227 chr14:105710500 BRF1 -0.8 -16.21 -0.54 8.86e-50 Mean platelet volume;Platelet distribution width; BRCA cis rs6598955 1.000 rs6598955 chr1:26619649 C/T cg00852783 chr1:26633632 UBXN11 -0.51 -11.03 -0.4 5.14e-26 Obesity-related traits; BRCA cis rs60843830 0.661 rs62116682 chr2:104618 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.67 0.32 3.43e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg11764359 chr7:65958608 NA 0.68 15.02 0.51 6.45e-44 Aortic root size; BRCA cis rs7246657 0.653 rs10406612 chr19:37716611 C/T cg23950597 chr19:37808831 NA -0.67 -10.14 -0.37 1.59e-22 Coronary artery calcification; BRCA cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs7246657 1.000 rs10426297 chr19:37798373 A/G cg18154014 chr19:37997991 ZNF793 0.53 10.14 0.37 1.74e-22 Coronary artery calcification; BRCA cis rs6964587 0.585 rs10266481 chr7:91554338 T/C cg17063962 chr7:91808500 NA -0.55 -12.67 -0.45 5.79e-33 Breast cancer; BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg13139843 chr21:31852793 KRTAP19-1 0.34 7.81 0.3 2.37e-14 HDL cholesterol; BRCA cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg10523679 chr1:76189770 ACADM -0.49 -9.79 -0.36 3.61e-21 Daytime sleep phenotypes; BRCA cis rs6964587 0.839 rs2049314 chr7:91464134 C/T cg17063962 chr7:91808500 NA 0.51 11.66 0.42 1.29e-28 Breast cancer; BRCA cis rs78456975 1.000 rs10205916 chr2:1558451 A/T cg01028140 chr2:1542097 TPO 0.79 15.4 0.52 9.17e-46 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg04267008 chr7:1944627 MAD1L1 -0.48 -10.83 -0.39 3.39e-25 Bipolar disorder and schizophrenia; BRCA cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg23711669 chr6:146136114 FBXO30 0.79 18.93 0.6 9.16e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.740 rs4845518 chr1:153003903 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.17 -0.31 1.67e-15 Inflammatory skin disease; BRCA trans rs11098499 0.644 rs28787668 chr4:120554687 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.2 0.37 9.69e-23 Corneal astigmatism; BRCA cis rs6594499 0.500 rs10491424 chr5:110453806 T/C cg04022379 chr5:110408740 TSLP 0.38 8.76 0.33 1.69e-17 Allergic disease (asthma, hay fever or eczema); BRCA cis rs317689 0.718 rs315122 chr12:69771073 G/T cg14784868 chr12:69753453 YEATS4 0.47 9.32 0.35 1.79e-19 Response to diuretic therapy; BRCA cis rs2668423 0.922 rs266805 chr19:1376723 C/T cg02639931 chr19:1387894 NDUFS7 -0.68 -15.34 -0.52 1.93e-45 Nonalcoholic fatty liver disease; BRCA cis rs6964587 0.621 rs38799 chr7:92045139 C/T cg17063962 chr7:91808500 NA -0.47 -10.34 -0.38 2.84e-23 Breast cancer; BRCA cis rs7131987 0.903 rs11050152 chr12:29404424 G/T cg09582351 chr12:29534625 ERGIC2 -0.49 -11.76 -0.42 5.03e-29 QT interval; BRCA cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.67 0.53 4.63e-47 Colorectal cancer; BRCA cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg13902645 chr11:5959945 NA -0.48 -9.9 -0.36 1.34e-21 DNA methylation (variation); BRCA cis rs4965272 0.830 rs11631646 chr15:100560259 C/T cg27344315 chr15:100560801 ADAMTS17 0.4 8.68 0.32 3.36e-17 Gastroesophageal reflux disease; BRCA cis rs2737618 0.574 rs2252801 chr1:200076652 C/T cg21825944 chr1:200113062 NR5A2 -0.4 -8.76 -0.33 1.81e-17 Uric acid levels; BRCA cis rs66887589 0.775 rs6843229 chr4:120424087 T/C cg09307838 chr4:120376055 NA 0.47 9.76 0.36 4.36e-21 Diastolic blood pressure; BRCA cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg13334819 chr7:99746414 C7orf59 0.35 8.17 0.31 1.63e-15 Coronary artery disease; BRCA cis rs4481887 1.000 rs10888351 chr1:248451608 G/A cg00666640 chr1:248458726 OR2T12 0.33 8.4 0.32 2.87e-16 Common traits (Other); BRCA cis rs10267417 0.603 rs10266969 chr7:19903452 G/A cg05791153 chr7:19748676 TWISTNB 0.47 9.1 0.34 1.13e-18 Night sleep phenotypes; BRCA cis rs10883723 0.810 rs17782574 chr10:104279394 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.25 0.59 3.22e-60 Allergic disease (asthma, hay fever or eczema); BRCA cis rs614226 1.000 rs614226 chr12:120974510 C/T cg27489772 chr12:121021490 NA -0.5 -8.7 -0.33 2.9e-17 Type 1 diabetes nephropathy; BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.74 -13.16 -0.46 3.59e-35 Gut microbiome composition (summer); BRCA cis rs7917772 0.636 rs10786708 chr10:104526245 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.42 10.61 0.39 2.41e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.84 -0.3 1.9e-14 Aortic root size; BRCA cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg04317338 chr11:64019027 PLCB3 0.55 9.52 0.35 3.59e-20 Mean platelet volume; BRCA cis rs2486288 0.656 rs8024620 chr15:45574329 C/T cg15395560 chr15:45543142 SLC28A2 0.29 7.96 0.3 8.07e-15 Glomerular filtration rate; BRCA cis rs2635047 0.967 rs12960444 chr18:44607314 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.42 9.29 0.34 2.43e-19 Educational attainment; BRCA cis rs6750047 0.771 rs1056836 chr2:38298203 C/G cg07380506 chr2:38303506 CYP1B1 -0.54 -13.1 -0.46 6.86e-35 Cutaneous malignant melanoma;Melanoma; BRCA cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg00012203 chr2:219082015 ARPC2 -0.4 -7.83 -0.3 2.1e-14 Ulcerative colitis; BRCA cis rs8141797 0.901 rs738808 chr22:24488461 C/T cg00411358 chr22:24577142 SUSD2 -0.74 -8.46 -0.32 1.79e-16 Amyotrophic lateral sclerosis;Coronary artery disease; BRCA cis rs11997175 0.583 rs7460295 chr8:33812288 C/T ch.8.33884649F chr8:33765107 NA 0.37 8.34 0.31 4.57e-16 Body mass index; BRCA cis rs2806561 0.929 rs2746556 chr1:23524541 G/A cg19743168 chr1:23544995 NA 0.45 11.15 0.4 1.74e-26 Height; BRCA cis rs12497850 0.931 rs13064911 chr3:48952385 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.44 0.35 6.72e-20 Parkinson's disease; BRCA cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg06627628 chr2:24431161 ITSN2 -0.82 -14.83 -0.51 5.87e-43 Asthma; BRCA cis rs9467773 0.935 rs4573 chr6:26546808 A/G cg09904177 chr6:26538194 HMGN4 0.52 14.81 0.51 7.33e-43 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs13087875 chr3:134261123 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.78 0.62 2.7e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4948102 0.642 rs6593297 chr7:56122058 A/T cg09872392 chr7:56161020 PHKG1 0.47 12.08 0.43 2.1000000000000002e-30 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7772486 0.875 rs9322046 chr6:146393625 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.57 0.5 1.03e-41 Lobe attachment (rater-scored or self-reported); BRCA trans rs4332037 0.624 rs11764337 chr7:1892309 A/G cg11693508 chr17:37793320 STARD3 -0.59 -11.36 -0.41 2.21e-27 Bipolar disorder; BRCA cis rs4481887 1.000 rs7513161 chr1:248453422 A/T cg00666640 chr1:248458726 OR2T12 0.33 8.63 0.32 4.83e-17 Common traits (Other); BRCA cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg03146154 chr1:46216737 IPP -0.47 -10.16 -0.37 1.39e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg05552183 chr6:42928497 GNMT 0.69 15.84 0.53 6.64e-48 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg25173405 chr17:45401733 C17orf57 -0.51 -10.91 -0.4 1.55e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4988958 0.527 rs11465641 chr2:103000868 T/G cg03938978 chr2:103052716 IL18RAP 0.29 8.41 0.32 2.59e-16 Asthma (childhood onset); BRCA cis rs17641971 0.645 rs341805 chr8:50034658 T/G cg00325661 chr8:49890786 NA 0.35 9.57 0.35 2.36e-20 Blood metabolite levels; BRCA trans rs7647973 0.593 rs9870755 chr3:49809841 A/G cg21659725 chr3:3221576 CRBN -0.47 -8.69 -0.33 3.14e-17 Menarche (age at onset); BRCA cis rs7255436 0.830 rs4350678 chr19:8447366 A/G cg10811474 chr19:8428787 ANGPTL4 -0.32 -8.05 -0.3 4.17e-15 HDL cholesterol; BRCA cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg13628971 chr7:2884303 GNA12 -0.41 -9.3 -0.35 2.16e-19 Height; BRCA cis rs11190604 1.000 rs2489045 chr10:102344754 C/T cg07080220 chr10:102295463 HIF1AN 0.62 13.16 0.46 3.41e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs13082711 0.516 rs1388785 chr3:27371843 T/C cg02860705 chr3:27208620 NA -0.38 -7.9 -0.3 1.21e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs312274 0.588 rs2897101 chr12:41318620 T/C cg17827154 chr12:41323612 CNTN1 -0.44 -10.98 -0.4 8.32e-26 Metabolite levels (X-11787); BRCA cis rs6684514 1.000 rs11264468 chr1:156274585 C/G cg16558208 chr1:156270281 VHLL 0.36 8.42 0.32 2.48e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs877282 1.000 rs71491304 chr10:772982 C/T cg17470449 chr10:769945 NA 0.5 9.35 0.35 1.44e-19 Uric acid levels; BRCA cis rs765787 0.530 rs2433228 chr15:45515371 A/C cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs4648739 0.613 rs13303201 chr1:1903712 G/T cg14196676 chr1:1911069 KIAA1751 -0.4 -8.45 -0.32 1.91e-16 Severe influenza A (H1N1) infection; BRCA cis rs295140 0.546 rs295119 chr2:201117944 C/T cg23649088 chr2:200775458 C2orf69 0.43 9.21 0.34 4.76e-19 QT interval; BRCA cis rs7208859 0.673 rs73265624 chr17:29232066 G/A cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6866344 0.570 rs1132338 chr5:178139442 T/G cg03877680 chr5:178157825 ZNF354A 0.82 16.4 0.54 9.89e-51 Neutrophil percentage of white cells; BRCA cis rs9858542 0.953 rs6803222 chr3:49665976 T/G cg03060546 chr3:49711283 APEH -0.58 -11.81 -0.42 3.12e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4363385 0.818 rs419721 chr1:153006902 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs10421328 0.848 rs10415278 chr19:19769157 C/A cg11584989 chr19:19387371 SF4 0.4 7.96 0.3 7.92e-15 Parental longevity (combined parental age at death); BRCA cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg21926612 chr6:163149169 PACRG;PARK2 -0.55 -10.39 -0.38 1.77e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11190604 1.000 rs11190589 chr10:102275471 A/G cg07080220 chr10:102295463 HIF1AN 0.6 14.07 0.49 2.28e-39 Palmitoleic acid (16:1n-7) levels; BRCA trans rs2834485 1.000 rs2834484 chr21:35816941 G/T cg07474852 chr4:123073612 NA -0.42 -9.18 -0.34 5.99e-19 Cancer; BRCA trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21582582 chr3:182698605 DCUN1D1 0.39 10.11 0.37 2.1e-22 Intelligence (multi-trait analysis); BRCA cis rs708547 0.723 rs35982175 chr4:57841365 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.41 -8.04 -0.3 4.28e-15 Response to bleomycin (chromatid breaks); BRCA cis rs208520 0.661 rs1100950 chr6:66827285 A/C cg07460842 chr6:66804631 NA -1.02 -19.97 -0.62 2.53e-69 Exhaled nitric oxide output; BRCA cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg17971929 chr21:40555470 PSMG1 -0.5 -11.24 -0.41 7.4e-27 Menarche (age at onset); BRCA cis rs2130392 0.926 rs10428357 chr4:185636217 T/A cg04058563 chr4:185651563 MLF1IP 0.35 8.75 0.33 1.93e-17 Kawasaki disease; BRCA trans rs2204008 0.683 rs11519834 chr12:38053575 T/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 7.99e-21 Bladder cancer; BRCA cis rs11690935 1.000 rs312924 chr2:172564021 A/T cg13550731 chr2:172543902 DYNC1I2 0.87 27.37 0.73 9.34e-110 Schizophrenia; BRCA cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg11764359 chr7:65958608 NA -0.69 -15.29 -0.52 3.29e-45 Aortic root size; BRCA cis rs2197308 0.765 rs12370231 chr12:37917881 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 3.07e-22 Morning vs. evening chronotype; BRCA cis rs2576037 0.526 rs509647 chr18:44383675 G/T cg19077165 chr18:44547161 KATNAL2 -0.52 -11.08 -0.4 3.15e-26 Personality dimensions; BRCA cis rs17601876 0.778 rs4774584 chr15:51562007 G/A cg19946085 chr15:51559439 CYP19A1 -0.39 -11.65 -0.42 1.47e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA trans rs9329221 0.736 rs11250002 chr8:10257041 T/G cg15556689 chr8:8085844 FLJ10661 0.37 8.91 0.33 5.43e-18 Neuroticism; BRCA cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg00071950 chr4:10020882 SLC2A9 0.61 14.44 0.5 3.99e-41 Bone mineral density; BRCA cis rs9649213 0.593 rs12672092 chr7:97986557 C/A cg24562669 chr7:97807699 LMTK2 0.45 12.04 0.43 3.16e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg08975724 chr8:8085496 FLJ10661 -0.44 -9.36 -0.35 1.31e-19 Mood instability; BRCA cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.39 0.35 1.05e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg21226059 chr5:178986404 RUFY1 0.53 14.95 0.51 1.56e-43 Lung cancer; BRCA trans rs11098499 0.562 rs58583086 chr4:120556362 A/G cg25214090 chr10:38739885 LOC399744 -0.41 -9.35 -0.35 1.43e-19 Corneal astigmatism; BRCA cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 -0.62 -15.6 -0.53 9.65e-47 Bone mineral density (spine);Bone mineral density; BRCA cis rs9393777 0.623 rs7773938 chr6:26474044 C/T cg12826209 chr6:26865740 GUSBL1 0.55 9.1 0.34 1.09e-18 Intelligence (multi-trait analysis); BRCA cis rs9420 0.961 rs11606396 chr11:57435211 C/T cg19752551 chr11:57585705 CTNND1 -0.5 -12.23 -0.44 4.61e-31 Schizophrenia; BRCA cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12292205 chr6:26970375 C6orf41 -0.5 -8.48 -0.32 1.54e-16 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg22764044 chr5:178986830 RUFY1 -0.47 -13.04 -0.46 1.29e-34 Lung cancer; BRCA cis rs751728 0.664 rs12190029 chr6:33749152 T/A cg25922239 chr6:33757077 LEMD2 0.51 12.87 0.45 6.89e-34 Crohn's disease; BRCA cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11644478 chr21:40555479 PSMG1 -0.5 -10.46 -0.38 9.91e-24 Menarche (age at onset); BRCA cis rs12545109 0.700 rs2670045 chr8:57393695 A/G cg09654669 chr8:57350985 NA -0.39 -8.18 -0.31 1.52e-15 Obesity-related traits; BRCA cis rs2115630 1.000 rs6496441 chr15:85363348 A/G cg11189052 chr15:85197271 WDR73 -0.36 -8.52 -0.32 1.1e-16 P wave terminal force; BRCA cis rs7727544 0.735 rs272884 chr5:131668654 G/C cg24060327 chr5:131705240 SLC22A5 -0.49 -10.39 -0.38 1.81e-23 Blood metabolite levels; BRCA cis rs11190604 1.000 rs11190595 chr10:102291761 T/C cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg18032046 chr6:28092343 ZSCAN16 0.5 8.22 0.31 1.12e-15 Depression; BRCA cis rs6835098 0.520 rs2127896 chr4:174211285 G/A cg08422745 chr4:174089978 GALNT7 -0.42 -7.82 -0.3 2.22e-14 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs9814567 1.000 rs7433663 chr3:134235790 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.63 -0.61 1.65e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg17420585 chr12:42539391 GXYLT1 -0.37 -7.85 -0.3 1.81e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs354225 0.565 rs2971880 chr2:54885640 A/T cg26097391 chr2:54893211 SPTBN1 0.29 8.84 0.33 9.54e-18 Schizophrenia; BRCA cis rs13161895 0.591 rs12655422 chr5:179480825 C/A cg02702477 chr5:179499311 RNF130 0.57 9.89 0.36 1.45e-21 LDL cholesterol; BRCA cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.58 -11.92 -0.43 9.81e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13046373 0.508 rs1911572 chr21:32031648 A/G cg06468780 chr21:31798236 KRTAP13-3 -0.35 -8.71 -0.33 2.53e-17 HDL cholesterol; BRCA cis rs7267979 0.966 rs4815414 chr20:25361701 A/G cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs10012271 chr4:99065154 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.78 0.39 5.16e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4478858 0.735 rs2271072 chr1:31840426 C/G cg00250761 chr1:31883323 NA -0.33 -8.49 -0.32 1.45e-16 Alcohol dependence; BRCA cis rs752010 0.695 rs11210508 chr1:42106935 A/G cg06885757 chr1:42089581 HIVEP3 0.22 8.28 0.31 7.05e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7760535 0.656 rs1883136 chr6:111907023 G/T cg22127309 chr6:111907043 TRAF3IP2 -0.37 -8.87 -0.33 7.5e-18 Metabolic traits; BRCA cis rs875971 0.545 rs6950988 chr7:65976415 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.51 9.71 0.36 6.71e-21 Aortic root size; BRCA cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg21433313 chr16:3507492 NAT15 0.42 8.68 0.32 3.16e-17 Tuberculosis; BRCA cis rs9733 0.818 rs11204695 chr1:150657011 T/G cg13175981 chr1:150552382 MCL1 0.46 10.37 0.38 2.12e-23 Tonsillectomy; BRCA cis rs11098499 0.863 rs1480939 chr4:120456927 T/C cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA trans rs7746199 0.736 rs34543938 chr6:27624640 A/G cg06606381 chr12:133084897 FBRSL1 -0.86 -8.5 -0.32 1.31e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg16586182 chr3:47516702 SCAP 0.57 12.32 0.44 1.93e-31 Colorectal cancer; BRCA cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg07148914 chr20:33460835 GGT7 -0.44 -9.33 -0.35 1.72e-19 Height; BRCA cis rs16976116 0.901 rs28449712 chr15:55500681 A/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.26 0.31 8.13e-16 Platelet count; BRCA cis rs68170813 0.559 rs74906766 chr7:106885236 T/A cg02696742 chr7:106810147 HBP1 -0.47 -7.92 -0.3 1.04e-14 Coronary artery disease; BRCA cis rs875971 1.000 rs3735148 chr7:65971009 T/G cg11764359 chr7:65958608 NA 0.8 19.36 0.61 4.38e-66 Aortic root size; BRCA cis rs875971 0.862 rs10950043 chr7:65988610 T/C cg18876405 chr7:65276391 NA 0.5 11.07 0.4 3.5e-26 Aortic root size; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg00166722 chr3:10149974 C3orf24 0.56 11.17 0.4 1.32e-26 Alzheimer's disease; BRCA cis rs858239 0.600 rs6961131 chr7:23134790 A/G cg23682824 chr7:23144976 KLHL7 0.45 12.22 0.44 5.34e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs4588572 0.643 rs7716529 chr5:77738637 A/T cg11547950 chr5:77652471 NA -0.45 -8.17 -0.31 1.63e-15 Triglycerides; BRCA cis rs921968 0.643 rs62191565 chr2:219482017 C/T cg02176678 chr2:219576539 TTLL4 0.43 11.56 0.42 3.36e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs7917772 0.503 rs7100753 chr10:104300979 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg17330251 chr7:94953956 PON1 -0.42 -8.85 -0.33 8.59e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg00677455 chr12:58241039 CTDSP2 0.79 19.91 0.62 5.19e-69 Multiple sclerosis; BRCA cis rs9486719 1.000 rs2472895 chr6:96870387 A/T cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.52e-34 Migraine;Coronary artery disease; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg03354898 chr7:1950403 MAD1L1 -0.44 -9.74 -0.36 5.48e-21 Bipolar disorder and schizophrenia; BRCA cis rs2073300 1.000 rs6132628 chr20:23446734 G/A cg12062639 chr20:23401060 NAPB 0.91 10.69 0.39 1.21e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.77 21.31 0.64 1.55e-76 Multiple sclerosis; BRCA cis rs7607369 0.680 rs533760 chr2:219381405 T/C cg10223061 chr2:219282414 VIL1 -0.27 -8.18 -0.31 1.49e-15 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs2070488 0.775 rs762318 chr3:38516369 C/A cg24069376 chr3:38537580 EXOG 0.34 9.37 0.35 1.18e-19 Electrocardiographic conduction measures; BRCA cis rs2882667 0.654 rs7710300 chr5:138170482 T/C cg04439458 chr5:138467593 SIL1 0.34 8.47 0.32 1.73e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs208520 1.000 rs12191403 chr6:66978137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.41 0.5 5.62e-41 Exhaled nitric oxide output; BRCA cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg03146154 chr1:46216737 IPP -0.54 -12.02 -0.43 3.92e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs3733585 0.673 rs4235347 chr4:9951956 C/T cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2.06e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs2559856 1.000 rs2695296 chr12:102085487 T/C cg12213457 chr12:102090980 CHPT1 -0.37 -7.99 -0.3 6.15e-15 Blood protein levels; BRCA cis rs6450176 0.597 rs1541682 chr5:53304401 C/T ch.5.1024479R chr5:53302184 ARL15 -0.86 -15.71 -0.53 2.71e-47 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs72781680 0.699 rs72796125 chr2:23919169 C/T cg08917208 chr2:24149416 ATAD2B 1.03 13.88 0.48 1.83e-38 Lymphocyte counts; BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg25036284 chr2:26402008 FAM59B 0.85 13.61 0.47 3.27e-37 Gut microbiome composition (summer); BRCA cis rs7639513 0.767 rs7617041 chr3:12709167 A/G cg23032965 chr3:12705835 RAF1 0.7 15.4 0.52 1e-45 Itch intensity from mosquito bite; BRCA cis rs2625529 0.775 rs35673773 chr15:72399886 C/A cg16672083 chr15:72433130 SENP8 -0.84 -17.47 -0.57 3.5e-56 Red blood cell count; BRCA cis rs1499972 0.941 rs56051552 chr3:117613726 C/T cg07612923 chr3:117604196 NA 0.59 8.01 0.3 5.48e-15 Schizophrenia; BRCA cis rs36051895 0.632 rs10815171 chr9:5172567 G/A cg02405213 chr9:5042618 JAK2 -0.49 -9.52 -0.35 3.39e-20 Pediatric autoimmune diseases; BRCA cis rs10411936 0.608 rs7259642 chr19:16601926 C/A cg10248733 chr19:16607483 C19orf44;CALR3 0.46 9.68 0.36 8.85e-21 White blood cell count;Multiple sclerosis; BRCA cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg18904891 chr8:8559673 CLDN23 0.64 12.88 0.45 6.38e-34 Obesity-related traits; BRCA cis rs7267979 1.000 rs2500443 chr20:25331442 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.55 -0.32 9.35e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7178424 0.729 rs12909947 chr15:62248552 C/T cg00456672 chr15:62358751 C2CD4A 0.38 9.2 0.34 5.15e-19 Height; BRCA cis rs514406 0.607 rs6696940 chr1:53203427 C/T cg16325326 chr1:53192061 ZYG11B -0.91 -24.72 -0.7 3.55e-95 Monocyte count; BRCA cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11644478 chr21:40555479 PSMG1 0.87 20.53 0.63 2.67e-72 Cognitive function; BRCA cis rs6545883 0.929 rs13413337 chr2:61747123 A/G cg15711740 chr2:61764176 XPO1 -0.52 -12.96 -0.46 2.91e-34 Tuberculosis; BRCA cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg11764359 chr7:65958608 NA 0.8 19.35 0.61 5.33e-66 Aortic root size; BRCA trans rs12517041 1.000 rs1428630 chr5:23321186 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs2806561 0.780 rs4655142 chr1:23333728 T/C cg19743168 chr1:23544995 NA -0.39 -9.4 -0.35 9.63e-20 Height; BRCA cis rs6570726 0.967 rs7772286 chr6:145930423 A/T cg23711669 chr6:146136114 FBXO30 -0.7 -16.88 -0.56 3.73e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.39 0.35 1.07e-19 Body mass index; BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg21782813 chr7:2030301 MAD1L1 0.42 12.13 0.43 1.32e-30 Bipolar disorder and schizophrenia; BRCA cis rs60871478 1.000 rs4719314 chr7:822523 A/G cg27478167 chr7:817139 HEATR2 -0.47 -9.89 -0.36 1.43e-21 Cerebrospinal P-tau181p levels; BRCA cis rs589448 0.902 rs315113 chr12:69786543 G/T cg22834771 chr12:69754056 YEATS4 0.39 9.79 0.36 3.46e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs4671400 0.602 rs2694623 chr2:61553466 C/T cg15711740 chr2:61764176 XPO1 0.45 8.85 0.33 8.87e-18 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs7662987 0.517 rs1133485 chr4:100023811 T/A cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Smoking initiation; BRCA trans rs3947 0.906 rs709822 chr8:11702313 C/G cg06636001 chr8:8085503 FLJ10661 -0.44 -8.0 -0.3 6.07e-15 Blood protein levels; BRCA cis rs1451375 0.657 rs12665904 chr7:50635399 A/G cg18232548 chr7:50535776 DDC 0.39 9.08 0.34 1.39e-18 Malaria; BRCA cis rs68170813 0.559 rs12536574 chr7:106810997 A/T cg02696742 chr7:106810147 HBP1 -0.54 -8.61 -0.32 5.6e-17 Coronary artery disease; BRCA cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg18230493 chr5:56204884 C5orf35 -0.72 -13.87 -0.48 1.95e-38 Initial pursuit acceleration; BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00166722 chr3:10149974 C3orf24 -0.57 -10.05 -0.37 3.67e-22 Alzheimer's disease; BRCA cis rs9611565 0.921 rs2143695 chr22:41728620 A/G cg03806693 chr22:41940476 POLR3H -0.61 -12.01 -0.43 4.06e-30 Vitiligo; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg16145915 chr7:1198662 ZFAND2A -0.72 -20.63 -0.63 6.98e-73 Longevity;Endometriosis; BRCA trans rs75804782 0.630 rs113725999 chr2:239287651 C/T cg01134436 chr17:81009848 B3GNTL1 0.74 7.95 0.3 8.38e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs7666738 0.861 rs5014702 chr4:99052102 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.17 0.56 1.28e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg17211192 chr8:82754475 SNX16 0.49 11.12 0.4 2.21e-26 Diastolic blood pressure; BRCA cis rs11190604 0.767 rs11190513 chr10:102165238 A/G cg07080220 chr10:102295463 HIF1AN 0.51 10.54 0.38 4.47e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4689592 0.503 rs3857180 chr4:7073899 T/G cg19539972 chr4:7069911 GRPEL1 -0.63 -12.03 -0.43 3.45e-30 Monocyte percentage of white cells; BRCA cis rs13191362 1.000 rs13199223 chr6:163001083 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10911251 0.508 rs6424890 chr1:183112764 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA cis rs881375 0.967 rs1930781 chr9:123687834 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.89 0.4 1.82e-25 Rheumatoid arthritis; BRCA cis rs11170631 0.507 rs12307701 chr12:54090724 A/C cg23533419 chr12:54090519 NA -0.33 -8.26 -0.31 8.57e-16 Height; BRCA cis rs11051970 0.594 rs325418 chr12:32572517 T/C cg02745156 chr12:32552066 NA 0.23 7.88 0.3 1.42e-14 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2712184 0.756 rs2712182 chr2:217647525 T/C cg05032264 chr2:217675019 NA -0.37 -8.97 -0.33 3.25e-18 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA trans rs2727020 0.823 rs7102374 chr11:49261795 G/A cg03929089 chr4:120376271 NA 0.72 14.7 0.5 2.49e-42 Coronary artery disease; BRCA cis rs939658 0.626 rs11636901 chr15:79446292 T/C cg17916960 chr15:79447300 NA -0.39 -9.83 -0.36 2.57e-21 Refractive error; BRCA cis rs12410462 1.000 rs12410462 chr1:227667790 A/G cg04117972 chr1:227635322 NA -0.5 -9.12 -0.34 9.69e-19 Major depressive disorder; BRCA cis rs12347191 0.500 rs907582 chr9:100621926 T/C cg13688889 chr9:100608707 NA -0.48 -9.8 -0.36 3.09e-21 Orofacial clefts; BRCA cis rs2832191 0.716 rs1888440 chr21:30454484 C/T cg24692254 chr21:30365293 RNF160 0.77 21.21 0.64 5.58e-76 Dental caries; BRCA cis rs9486719 1.000 rs4839837 chr6:96908706 G/A cg06623918 chr6:96969491 KIAA0776 0.75 15.83 0.53 7.37e-48 Migraine;Coronary artery disease; BRCA cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg16339924 chr4:17578868 LAP3 0.63 15.63 0.53 7.33e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2204008 0.840 rs7136347 chr12:38453531 G/A cg06521331 chr12:34319734 NA -0.51 -9.24 -0.34 3.5e-19 Bladder cancer; BRCA cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.95 -0.4 1.12e-25 Personality dimensions; BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg03609598 chr5:56110824 MAP3K1 -0.45 -7.99 -0.3 6.34e-15 Initial pursuit acceleration; BRCA cis rs1153858 1.000 rs8032904 chr15:45651309 C/T cg21132104 chr15:45694354 SPATA5L1 0.74 16.86 0.55 5.12e-53 Homoarginine levels; BRCA cis rs748404 0.723 rs11853991 chr15:43557549 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.35 8.13 0.31 2.3e-15 Lung cancer; BRCA cis rs4363385 0.668 rs6587717 chr1:152984443 G/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.89 -0.36 1.52e-21 Inflammatory skin disease; BRCA cis rs6665290 0.901 rs7535826 chr1:227213968 A/C cg10327440 chr1:227177885 CDC42BPA 1.06 38.63 0.84 2.61e-169 Myeloid white cell count; BRCA cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg04455712 chr21:45112962 RRP1B 0.36 9.44 0.35 6.82e-20 Mean corpuscular volume; BRCA cis rs7312933 0.510 rs10880223 chr12:42413443 G/A cg17420585 chr12:42539391 GXYLT1 -0.58 -14.47 -0.5 2.84e-41 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs595982 0.527 rs73061659 chr19:49373556 G/A cg15549821 chr19:49342101 PLEKHA4 -0.71 -11.43 -0.41 1.2100000000000001e-27 Red cell distribution width; BRCA trans rs11098499 0.863 rs6858592 chr4:120458692 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.15 0.31 1.99e-15 Corneal astigmatism; BRCA cis rs61931739 0.534 rs10844767 chr12:34152368 C/G cg06521331 chr12:34319734 NA -0.62 -11.41 -0.41 1.38e-27 Morning vs. evening chronotype; BRCA cis rs6964587 0.773 rs13236026 chr7:91885873 A/G cg17063962 chr7:91808500 NA 0.51 11.01 0.4 6.08e-26 Breast cancer; BRCA cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg18132916 chr6:79620363 NA -0.49 -11.12 -0.4 2.14e-26 Intelligence (multi-trait analysis); BRCA cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg17509989 chr5:176798049 RGS14 -0.62 -12.55 -0.44 1.9e-32 Hemoglobin concentration;Hematocrit; BRCA cis rs6088580 0.634 rs2378134 chr20:32938085 C/T cg08999081 chr20:33150536 PIGU -0.45 -12.27 -0.44 3.08e-31 Glomerular filtration rate (creatinine); BRCA cis rs9467773 0.526 rs9348710 chr6:26360486 A/C cg09904177 chr6:26538194 HMGN4 -0.32 -8.72 -0.33 2.41e-17 Intelligence (multi-trait analysis); BRCA cis rs654950 1.000 rs679449 chr1:41988634 G/T cg06885757 chr1:42089581 HIVEP3 -0.28 -9.46 -0.35 5.78e-20 Airway imaging phenotypes; BRCA cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg15839431 chr19:19639596 YJEFN3 -0.39 -8.54 -0.32 1.01e-16 Bipolar disorder; BRCA trans rs61931739 0.500 rs10844844 chr12:34380350 G/T cg13010199 chr12:38710504 ALG10B 0.48 9.55 0.35 2.79e-20 Morning vs. evening chronotype; BRCA cis rs12497850 0.931 rs7626445 chr3:49114544 C/T cg06212747 chr3:49208901 KLHDC8B 0.48 9.91 0.37 1.2e-21 Parkinson's disease; BRCA trans rs12517041 1.000 rs12697619 chr5:23288772 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA trans rs7618501 0.572 rs4688756 chr3:50040194 T/A cg21659725 chr3:3221576 CRBN 0.42 10.36 0.38 2.32e-23 Intelligence (multi-trait analysis); BRCA cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg11812906 chr14:75593930 NEK9 -0.61 -14.21 -0.49 5.25e-40 Height; BRCA cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg25427524 chr10:38739819 LOC399744 -0.67 -16.22 -0.54 8.33e-50 Extrinsic epigenetic age acceleration; BRCA trans rs35110281 0.806 rs1454649 chr21:45032982 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.27 0.38 5.09e-23 Mean corpuscular volume; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.39 8.69 0.33 3.02e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs34779708 0.931 rs12240347 chr10:35359475 A/G cg03585969 chr10:35415529 CREM 0.46 9.55 0.35 2.69e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4771122 0.728 rs1475221 chr13:28037566 C/T cg22138327 chr13:27999177 GTF3A -0.44 -8.53 -0.32 1.05e-16 Body mass index; BRCA cis rs13064411 0.735 rs6438158 chr3:113217290 C/T cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs1707322 1.000 rs785484 chr1:46574015 T/C cg06784218 chr1:46089804 CCDC17 -0.46 -10.78 -0.39 5.33e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs8002861 0.664 rs4941474 chr13:44450289 C/T cg12856521 chr11:46389249 DGKZ 0.36 7.87 0.3 1.5e-14 Leprosy; BRCA cis rs3755132 0.929 rs976016 chr2:15772865 A/G cg12888861 chr2:15731646 DDX1 0.4 8.03 0.3 4.77e-15 Wilms tumor; BRCA cis rs1915146 0.967 rs7086481 chr10:126844523 A/T cg05090351 chr10:126851162 NA -0.3 -8.24 -0.31 1e-15 Menarche (age at onset); BRCA cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg00071950 chr4:10020882 SLC2A9 -0.47 -11.19 -0.4 1.16e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17345786 0.520 rs13062677 chr3:101305078 G/A cg12386194 chr3:101231763 SENP7 0.41 8.97 0.33 3.21e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs881375 0.900 rs2241003 chr9:123666777 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 9.09 0.34 1.25e-18 Rheumatoid arthritis; BRCA cis rs4727027 0.840 rs12670633 chr7:148796707 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.73 0.39 8.38e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10751667 0.621 rs10794348 chr11:939941 G/A cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.04e-15 Alzheimer's disease (late onset); BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg26668828 chr6:292823 DUSP22 0.56 12.16 0.43 9.82e-31 Menopause (age at onset); BRCA trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg15704280 chr7:45808275 SEPT13 0.58 9.99 0.37 5.97e-22 Axial length; BRCA cis rs6005807 0.719 rs7289625 chr22:28896546 G/A cg12565055 chr22:29076175 TTC28 0.47 8.37 0.31 3.6e-16 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg00166722 chr3:10149974 C3orf24 0.57 10.99 0.4 7.79e-26 Alzheimer's disease; BRCA cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.87 0.4 2.23e-25 Rheumatoid arthritis; BRCA cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg18404041 chr3:52824283 ITIH1 -0.43 -12.7 -0.45 3.92e-33 Bipolar disorder; BRCA cis rs2030114 0.531 rs1072858 chr16:51593364 C/T cg03758633 chr16:51611768 NA 0.36 7.82 0.3 2.17e-14 Blood pressure measurement (high sodium and potassium intervention); BRCA cis rs6484504 0.625 rs10835766 chr11:31374329 C/A cg14844989 chr11:31128820 NA 0.44 9.7 0.36 7.84e-21 Red blood cell count; BRCA cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg25554036 chr4:6271136 WFS1 0.37 7.98 0.3 6.95e-15 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1003719 0.788 rs1543749 chr21:38446621 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.19 0.49 6.57e-40 Eye color traits; BRCA cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg21361702 chr7:150065534 REPIN1 -0.55 -9.97 -0.37 7.49e-22 Blood protein levels;Circulating chemerin levels; BRCA cis rs13046373 0.535 rs1395778 chr21:31985502 G/C cg14062083 chr21:31802829 KRTAP13-4 0.32 8.58 0.32 6.91e-17 HDL cholesterol; BRCA cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg18198730 chr1:247681584 NA 0.56 12.4 0.44 8.18e-32 Acute lymphoblastic leukemia (childhood); BRCA cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg22676075 chr6:135203613 NA 0.44 8.66 0.32 3.87e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13126279 chr21:47581558 C21orf56 -0.49 -10.85 -0.39 2.81e-25 Testicular germ cell tumor; BRCA cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg24558204 chr6:135376177 HBS1L -0.41 -10.55 -0.39 4.29e-24 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2979489 0.891 rs2979504 chr8:30386641 C/T cg26383811 chr8:30366931 RBPMS -0.55 -12.7 -0.45 4.26e-33 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs7598759 0.617 rs6437017 chr2:232327584 C/A cg19187155 chr2:232395269 NMUR1 0.38 7.97 0.3 7.57e-15 Noise-induced hearing loss; BRCA cis rs3106136 0.546 rs4693003 chr4:95145469 A/G cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.08 -0.37 2.88e-22 Capecitabine sensitivity; BRCA cis rs7582180 0.629 rs4851294 chr2:100941109 C/T cg14675211 chr2:100938903 LONRF2 0.44 10.29 0.38 4.45e-23 Intelligence (multi-trait analysis); BRCA cis rs2882667 0.654 rs883333 chr5:138155470 C/A cg04439458 chr5:138467593 SIL1 0.36 8.88 0.33 6.46e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg07308232 chr7:1071921 C7orf50 -0.44 -9.18 -0.34 5.73e-19 Longevity;Endometriosis; BRCA cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7264396 1.000 rs224436 chr20:34154124 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -9.39 -0.35 1e-19 Total cholesterol levels; BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg14863265 chr7:2801509 GNA12 -0.45 -9.72 -0.36 6.27e-21 Height; BRCA cis rs2836950 0.545 rs2836940 chr21:40588696 T/C cg17971929 chr21:40555470 PSMG1 -0.48 -10.67 -0.39 1.42e-24 Menarche (age at onset); BRCA trans rs6479891 1.000 rs11814792 chr10:64917559 C/T cg14819942 chr15:35414228 NA 0.35 8.63 0.32 5.03e-17 Arthritis (juvenile idiopathic); BRCA cis rs11792861 0.816 rs7027263 chr9:111699569 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.99 0.3 6.19e-15 Menarche (age at onset); BRCA trans rs7200543 1.000 rs1136001 chr16:15131974 G/T cg24683922 chr1:11983373 KIAA2013 -0.39 -8.71 -0.33 2.69e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs4595586 0.545 rs12819061 chr12:39386976 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs17092148 0.945 rs6060009 chr20:33303974 T/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.29 -0.41 4.4e-27 Neuroticism; BRCA cis rs2732480 0.538 rs1387260 chr12:48703091 A/C cg04545296 chr12:48745243 ZNF641 0.24 7.9 0.3 1.21e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs875971 0.965 rs9969301 chr7:65781655 G/A cg18876405 chr7:65276391 NA -0.55 -13.2 -0.46 2.49e-35 Aortic root size; BRCA trans rs12310956 0.515 rs115836245 chr12:33951369 T/C cg26384229 chr12:38710491 ALG10B 0.46 10.25 0.38 6.32e-23 Morning vs. evening chronotype; BRCA trans rs1973993 0.689 rs67544133 chr1:96971241 G/A cg10631902 chr5:14652156 NA -0.48 -13.88 -0.48 1.76e-38 Weight; BRCA cis rs7264396 0.563 rs2225950 chr20:34333015 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.91 -0.43 1.13e-29 Total cholesterol levels; BRCA trans rs208520 0.608 rs3846803 chr6:66805743 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.13 -0.64 1.45e-75 Exhaled nitric oxide output; BRCA cis rs9341808 0.905 rs9343977 chr6:80967001 C/T cg08355045 chr6:80787529 NA 0.36 9.53 0.35 3.1e-20 Sitting height ratio; BRCA cis rs11690935 0.959 rs12692970 chr2:172594197 T/C cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.73 -0.77 4.91e-128 Schizophrenia; BRCA cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg24578937 chr1:2090814 PRKCZ -0.3 -9.35 -0.35 1.49e-19 Height; BRCA cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg18876405 chr7:65276391 NA -0.63 -15.65 -0.53 5.63e-47 Aortic root size; BRCA cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg18132916 chr6:79620363 NA -0.5 -11.34 -0.41 2.73e-27 Intelligence (multi-trait analysis); BRCA cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.92 0.4 1.39e-25 Cognitive ability; BRCA cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg20503657 chr10:835505 NA 0.85 15.16 0.51 1.45e-44 Eosinophil percentage of granulocytes; BRCA cis rs9287719 0.624 rs10199831 chr2:10726863 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs1577917 0.740 rs9344533 chr6:86236188 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 9.04 0.34 1.79e-18 Response to antipsychotic treatment; BRCA cis rs2243480 1.000 rs316332 chr7:65604299 A/G cg18252515 chr7:66147081 NA -1.01 -15.1 -0.51 2.74e-44 Diabetic kidney disease; BRCA cis rs7772486 0.846 rs1854901 chr6:146325685 T/C cg23711669 chr6:146136114 FBXO30 0.65 14.71 0.5 2.12e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.45 0.57 4.59e-56 Bladder cancer; BRCA cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg18876405 chr7:65276391 NA -0.5 -11.2 -0.41 1.06e-26 Aortic root size; BRCA cis rs561341 0.883 rs1034626 chr17:30219500 C/G cg13647721 chr17:30228624 UTP6 -0.58 -9.8 -0.36 3.27e-21 Hip circumference adjusted for BMI; BRCA cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg02187348 chr16:89574699 SPG7 0.43 9.99 0.37 6.21e-22 Multiple myeloma (IgH translocation); BRCA cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.27 0.41 5.23e-27 Bipolar disorder; BRCA trans rs6951245 0.935 rs61910751 chr7:1097895 A/G cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2239547 0.562 rs6794389 chr3:53096394 A/G cg11645453 chr3:52864694 ITIH4 0.42 9.93 0.37 1.02e-21 Schizophrenia; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg11843238 chr5:131593191 PDLIM4 0.41 10.35 0.38 2.63e-23 Acylcarnitine levels; BRCA cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.92 0.37 1.18e-21 Aortic root size; BRCA cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg26248373 chr2:1572462 NA -0.62 -14.37 -0.49 8.48e-41 IgG glycosylation; BRCA trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21659725 chr3:3221576 CRBN -0.47 -11.88 -0.43 1.57e-29 Intelligence (multi-trait analysis); BRCA cis rs3762637 0.943 rs6762156 chr3:122236025 A/C cg24169773 chr3:122142474 KPNA1 -0.43 -8.01 -0.3 5.54e-15 LDL cholesterol levels; BRCA cis rs9290065 0.519 rs6441345 chr3:160696867 C/T cg03342759 chr3:160939853 NMD3 -0.48 -9.81 -0.36 3.02e-21 Kawasaki disease; BRCA cis rs169738 1 rs169738 chr6:33537546 A/G cg07679836 chr6:33548423 BAK1 0.41 9.19 0.34 5.59e-19 Platelet count;Autism spectrum disorder or schizophrenia; BRCA cis rs2070488 0.804 rs2268755 chr3:38501916 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.66 -17.82 -0.58 6.01e-58 Electrocardiographic conduction measures; BRCA cis rs798554 0.679 rs2533868 chr7:2886559 G/A cg04166393 chr7:2884313 GNA12 0.63 13.71 0.48 1.05e-37 Height; BRCA trans rs4650994 0.507 rs12141152 chr1:178514165 C/T cg05059571 chr16:84539110 KIAA1609 -0.58 -12.87 -0.45 7.42e-34 HDL cholesterol levels;HDL cholesterol; BRCA cis rs903263 0.562 rs35452337 chr1:84534503 C/A cg10977910 chr1:84465055 TTLL7 0.42 8.07 0.3 3.6e-15 Breast cancer (male); BRCA cis rs4363385 0.818 rs946096 chr1:153006529 T/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs17601876 0.843 rs28518777 chr15:51553507 G/A cg19946085 chr15:51559439 CYP19A1 -0.36 -9.81 -0.36 2.92e-21 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs4363385 0.818 rs370162 chr1:153005488 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg23719950 chr11:63933701 MACROD1 -0.58 -9.45 -0.35 6.17e-20 Mean platelet volume; BRCA cis rs1065656 0.571 rs2745170 chr16:1835231 G/T cg08610935 chr16:1836813 NUBP2 0.46 11.73 0.42 6.42e-29 Insulin-like growth factors; BRCA cis rs12545109 0.879 rs7845180 chr8:57324431 C/T cg09654669 chr8:57350985 NA 0.39 8.57 0.32 7.99e-17 Obesity-related traits; BRCA cis rs7178424 0.790 rs17271305 chr15:62332980 A/G cg00456672 chr15:62358751 C2CD4A -0.41 -9.03 -0.34 1.99e-18 Height; BRCA cis rs17270561 0.943 rs76703022 chr6:25703529 A/C cg16482183 chr6:26056742 HIST1H1C 0.59 10.22 0.37 8.25e-23 Iron status biomarkers; BRCA cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg11764359 chr7:65958608 NA 0.79 19.31 0.61 8.49e-66 Aortic root size; BRCA cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg06060754 chr5:176797920 RGS14 0.7 10.49 0.38 7.52e-24 Urate levels in lean individuals; BRCA cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg12311346 chr5:56204834 C5orf35 -0.82 -16.75 -0.55 1.84e-52 Initial pursuit acceleration; BRCA cis rs6723226 0.961 rs13010404 chr2:32848854 T/G cg02381751 chr2:32503542 YIPF4 -0.49 -10.23 -0.38 7.28e-23 Intelligence (multi-trait analysis); BRCA cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg18404041 chr3:52824283 ITIH1 0.48 14.59 0.5 7.94e-42 Bipolar disorder; BRCA cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg27286337 chr10:134555280 INPP5A 0.65 11.66 0.42 1.25e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4812048 0.649 rs3761255 chr20:57618802 T/C cg14073986 chr20:57617431 SLMO2 0.78 12.17 0.43 8.34e-31 Mean platelet volume; BRCA cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg10523679 chr1:76189770 ACADM 0.78 18.67 0.59 2.07e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7851660 0.967 rs10818133 chr9:100610348 C/G cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.81e-17 Strep throat; BRCA cis rs7246657 0.943 rs6508733 chr19:38000548 A/T cg14683738 chr19:37701593 ZNF585B 0.46 8.1 0.31 2.86e-15 Coronary artery calcification; BRCA cis rs514406 0.830 rs533935 chr1:53308807 T/C cg27535305 chr1:53392650 SCP2 -0.36 -8.87 -0.33 7.19e-18 Monocyte count; BRCA cis rs908922 0.651 rs4240886 chr1:152530396 A/T cg20991723 chr1:152506922 NA -0.36 -8.02 -0.3 4.93e-15 Hair morphology; BRCA cis rs36051895 0.659 rs3780365 chr9:5068520 T/C cg02405213 chr9:5042618 JAK2 -0.5 -9.49 -0.35 4.66e-20 Pediatric autoimmune diseases; BRCA cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg06092702 chr1:163392909 NA -0.33 -8.84 -0.33 9.42e-18 Motion sickness; BRCA cis rs96067 0.740 rs10752586 chr1:36614713 C/G cg24686825 chr1:36642396 MAP7D1 -0.45 -8.4 -0.32 2.79e-16 Corneal structure; BRCA cis rs11676348 0.783 rs13035513 chr2:218960680 C/T cg00012203 chr2:219082015 ARPC2 -0.41 -7.91 -0.3 1.1e-14 Ulcerative colitis; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg15787769 chr11:842744 TSPAN4;POLR2L -0.57 -13.37 -0.47 4.1e-36 Mean platelet volume; BRCA cis rs208520 0.874 rs208481 chr6:66922636 A/G cg07460842 chr6:66804631 NA -0.89 -15.64 -0.53 6.62e-47 Exhaled nitric oxide output; BRCA cis rs490234 0.867 rs829181 chr9:128288002 A/G cg14078157 chr9:128172775 NA 0.34 8.05 0.3 3.93e-15 Mean arterial pressure; BRCA cis rs9311474 1.000 rs1060330 chr3:52288945 T/C cg18404041 chr3:52824283 ITIH1 -0.29 -8.14 -0.31 2.08e-15 Electroencephalogram traits; BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg10729496 chr3:10149963 C3orf24 0.49 9.41 0.35 8.99e-20 Alzheimer's disease; BRCA cis rs7666738 0.716 rs7656233 chr4:99079237 G/A cg05340658 chr4:99064831 C4orf37 0.64 14.83 0.51 5.78e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs501916 0.634 rs1561482 chr15:48069663 G/A cg16110827 chr15:48056943 SEMA6D -0.41 -8.83 -0.33 9.95e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7267979 1.000 rs2259956 chr20:25282433 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.1e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -9.52 -0.35 3.5e-20 Personality dimensions; BRCA cis rs12971120 1.000 rs12971120 chr18:72174023 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -15.08 -0.51 3.46e-44 Refractive error; BRCA cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg06784218 chr1:46089804 CCDC17 -0.52 -12.62 -0.45 8.86e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12210905 0.688 rs10456051 chr6:27463436 T/C cg08851530 chr6:28072375 NA 0.81 7.97 0.3 7.34e-15 Hip circumference adjusted for BMI; BRCA cis rs490234 0.812 rs12553699 chr9:128294526 C/G cg14078157 chr9:128172775 NA -0.5 -11.25 -0.41 6.5e-27 Mean arterial pressure; BRCA cis rs1707322 0.964 rs785516 chr1:46564758 T/G cg06784218 chr1:46089804 CCDC17 -0.46 -10.78 -0.39 5.33e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7246657 0.722 rs8103647 chr19:38100452 C/A cg18154014 chr19:37997991 ZNF793 0.5 9.54 0.35 2.99e-20 Coronary artery calcification; BRCA cis rs11984145 1.000 rs16879964 chr7:38834868 C/T cg19327137 chr7:38886074 VPS41 0.45 8.07 0.3 3.58e-15 Cognitive performance; BRCA cis rs1215050 0.791 rs260902 chr4:98764694 G/A cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs600231 0.708 rs2957268 chr11:65245816 A/G cg01292856 chr11:65242576 NA 0.33 8.32 0.31 5.35e-16 Bone mineral density; BRCA cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg27015174 chr15:43622946 ADAL;LCMT2 0.52 9.11 0.34 1.09e-18 Lung cancer in ever smokers; BRCA cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23221052 chr5:179740743 GFPT2 -0.68 -14.44 -0.5 3.97e-41 Height; BRCA cis rs3099143 1.000 rs7172639 chr15:77165288 G/A cg21673338 chr15:77095150 SCAPER 0.53 9.5 0.35 4.3e-20 Recalcitrant atopic dermatitis; BRCA cis rs4242434 0.927 rs2291232 chr8:22464064 A/G cg03733263 chr8:22462867 KIAA1967 1.02 25.29 0.71 2.68e-98 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs4285028 0.731 rs2332035 chr3:121715432 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.5 -9.02 -0.34 2.12e-18 Multiple sclerosis; BRCA cis rs7927771 0.524 rs4752865 chr11:47759841 G/A cg20307385 chr11:47447363 PSMC3 -0.41 -9.56 -0.35 2.4e-20 Subjective well-being; BRCA trans rs7980799 0.816 rs4587807 chr12:33510115 C/T cg26384229 chr12:38710491 ALG10B -0.34 -8.1 -0.31 2.85e-15 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs1975991 0.576 rs6768760 chr3:187957642 A/T cg15417654 chr3:187959138 LPP 0.36 9.37 0.35 1.18e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.49 10.89 0.4 1.87e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg20503657 chr10:835505 NA 0.52 9.22 0.34 4.4e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg19678392 chr7:94953810 PON1 -0.41 -8.53 -0.32 1.04e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg17644776 chr2:200775616 C2orf69 0.42 8.7 0.33 2.81e-17 Osteoporosis; BRCA cis rs6942756 1.000 rs66538149 chr7:128974061 G/A cg02491457 chr7:128862824 NA -0.71 -13.69 -0.48 1.39e-37 White matter hyperintensity burden; BRCA cis rs35740288 0.929 rs11073537 chr15:86312681 G/A cg20737812 chr15:86336631 KLHL25 -0.33 -7.89 -0.3 1.29e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs919433 0.679 rs6719832 chr2:198533369 C/T cg00792783 chr2:198669748 PLCL1 -0.4 -9.19 -0.34 5.34e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2625529 0.824 rs2415121 chr15:72134018 C/T cg16672083 chr15:72433130 SENP8 -0.68 -16.12 -0.54 2.79e-49 Red blood cell count; BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.91 16.45 0.55 5.62e-51 Platelet count; BRCA cis rs2237234 1.000 rs2237234 chr6:26391394 G/A cg12826209 chr6:26865740 GUSBL1 0.41 7.9 0.3 1.21e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.19 0.31 1.44e-15 Mean platelet volume; BRCA cis rs244731 0.919 rs12652509 chr5:176626441 A/G cg17509989 chr5:176798049 RGS14 -0.74 -11.79 -0.42 3.79e-29 Urate levels in lean individuals; BRCA cis rs10751667 0.666 rs6597966 chr11:950750 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA cis rs666930 0.519 rs532303 chr1:120265444 A/G cg19096424 chr1:120255104 PHGDH 0.59 13.72 0.48 9.81e-38 Breast cancer; BRCA cis rs7944584 0.551 rs12224672 chr11:47500400 C/T cg03711944 chr11:47377212 SPI1 -0.43 -9.97 -0.37 7.12e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2243480 1.000 rs1499614 chr7:65730798 A/T cg18252515 chr7:66147081 NA -1.04 -15.65 -0.53 5.53e-47 Diabetic kidney disease; BRCA cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg12927641 chr6:109611667 NA -0.42 -10.87 -0.39 2.35e-25 Reticulocyte fraction of red cells; BRCA trans rs11098499 0.866 rs6847778 chr4:120293582 A/G cg25214090 chr10:38739885 LOC399744 0.5 11.54 0.42 4.06e-28 Corneal astigmatism; BRCA cis rs6486730 1.000 rs6486730 chr12:129275027 C/T cg09035930 chr12:129282057 SLC15A4 0.3 8.07 0.3 3.61e-15 Systemic lupus erythematosus; BRCA cis rs6942756 0.806 rs7794622 chr7:128996268 T/C cg02491457 chr7:128862824 NA -0.59 -12.31 -0.44 2.03e-31 White matter hyperintensity burden; BRCA cis rs2070488 0.965 rs7640050 chr3:38525864 A/C cg24069376 chr3:38537580 EXOG 0.43 12.34 0.44 1.55e-31 Electrocardiographic conduction measures; BRCA trans rs9291683 0.546 rs10939672 chr4:10052136 A/G cg26043149 chr18:55253948 FECH 0.39 8.54 0.32 1.02e-16 Bone mineral density; BRCA cis rs7809950 0.817 rs2712195 chr7:107127496 C/T cg23024343 chr7:107201750 COG5 -0.48 -10.29 -0.38 4.31e-23 Coronary artery disease; BRCA cis rs11105298 0.685 rs117578503 chr12:89836672 G/C cg00757033 chr12:89920650 WDR51B 0.54 10.85 0.39 2.64e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6545883 0.931 rs778756 chr2:61781994 A/G cg15711740 chr2:61764176 XPO1 -0.48 -11.74 -0.42 5.71e-29 Tuberculosis; BRCA cis rs7264396 0.563 rs2425103 chr20:34312329 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.18 -0.43 7.96e-31 Total cholesterol levels; BRCA cis rs1568889 0.877 rs7933326 chr11:28288416 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.46 0.5 3.17e-41 Bipolar disorder; BRCA cis rs4713118 0.866 rs9468217 chr6:27726467 G/A cg20933634 chr6:27740509 NA 0.43 8.21 0.31 1.22e-15 Parkinson's disease; BRCA cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.22 0.31 1.16e-15 Axial length; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg13628971 chr7:2884303 GNA12 -0.42 -8.45 -0.32 1.93e-16 Height; BRCA cis rs875971 0.666 rs13242072 chr7:65765988 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.2 -0.31 1.28e-15 Aortic root size; BRCA cis rs7086627 0.515 rs10887896 chr10:82210144 A/C cg01528321 chr10:82214614 TSPAN14 0.62 13.83 0.48 3.07e-38 Post bronchodilator FEV1; BRCA cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg26597838 chr10:835615 NA 1.01 17.99 0.58 7.38e-59 Eosinophil percentage of granulocytes; BRCA cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.42 9.23 0.34 3.85e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs208520 0.779 rs208451 chr6:66906155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -15.98 -0.53 1.37e-48 Exhaled nitric oxide output; BRCA cis rs96067 0.711 rs4653164 chr1:36627542 A/G cg24686825 chr1:36642396 MAP7D1 0.39 8.44 0.32 2.15e-16 Corneal structure; BRCA cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg13628971 chr7:2884303 GNA12 0.36 7.94 0.3 9.3e-15 Height; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 20.94 0.64 1.66e-74 Platelet count; BRCA cis rs7824557 0.806 rs6601574 chr8:11094885 G/A cg21775007 chr8:11205619 TDH -0.47 -9.36 -0.35 1.29e-19 Retinal vascular caliber; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg11141652 chr22:24348549 GSTTP1 0.38 7.93 0.3 9.9e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg02297831 chr4:17616191 MED28 0.34 7.86 0.3 1.6e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9467711 0.538 rs35942482 chr6:26444938 T/A cg01620082 chr3:125678407 NA -0.65 -8.7 -0.33 2.73e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs7927771 0.524 rs10838760 chr11:47786414 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs7927592 0.871 rs113020558 chr11:68296832 G/A cg20283391 chr11:68216788 NA -0.48 -9.39 -0.35 1.02e-19 Total body bone mineral density; BRCA cis rs7617773 0.710 rs36064160 chr3:48243101 C/G cg11946769 chr3:48343235 NME6 0.68 13.87 0.48 2.02e-38 Coronary artery disease; BRCA cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg21856205 chr7:94953877 PON1 -0.38 -8.24 -0.31 9.47e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg06671706 chr8:8559999 CLDN23 0.41 7.91 0.3 1.16e-14 Obesity-related traits; BRCA cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg11366901 chr6:160182831 ACAT2 0.82 15.63 0.53 7.22e-47 Age-related macular degeneration (geographic atrophy); BRCA cis rs17641971 0.619 rs7013425 chr8:49953085 G/A cg00325661 chr8:49890786 NA 0.38 10.6 0.39 2.59e-24 Blood metabolite levels; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -8.07 -0.3 3.47e-15 Lymphocyte counts; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg07308232 chr7:1071921 C7orf50 -0.35 -7.81 -0.3 2.38e-14 Longevity;Endometriosis; BRCA cis rs4974559 0.739 rs28444605 chr4:1290281 C/A cg02980000 chr4:1222292 CTBP1 0.81 13.35 0.47 4.74e-36 Systolic blood pressure; BRCA cis rs10845606 1.000 rs10845609 chr12:12838920 T/A cg09462578 chr12:12878428 APOLD1 -0.63 -11.17 -0.4 1.42e-26 Systemic lupus erythematosus; BRCA cis rs7618501 0.602 rs2624853 chr3:50128893 A/G cg05623727 chr3:50126028 RBM5 -0.43 -10.25 -0.38 6.54e-23 Intelligence (multi-trait analysis); BRCA cis rs12612619 0.704 rs6754356 chr2:27315021 G/A cg00617064 chr2:27272375 NA -0.34 -8.88 -0.33 6.82e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg18016565 chr1:150552671 MCL1 -0.45 -9.97 -0.37 7.3e-22 Tonsillectomy; BRCA trans rs4689592 0.546 rs907523 chr4:7052777 A/G cg07817883 chr1:32538562 TMEM39B -0.46 -8.87 -0.33 7.11e-18 Monocyte percentage of white cells; BRCA cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg20701182 chr2:24300061 SF3B14 0.58 8.98 0.33 2.93e-18 Lymphocyte counts; BRCA cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg02556042 chr12:117471086 NA 0.58 9.92 0.37 1.16e-21 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs7246657 0.678 rs4802024 chr19:38052193 T/C cg23950597 chr19:37808831 NA -0.5 -8.62 -0.32 5.36e-17 Coronary artery calcification; BRCA cis rs4713118 0.516 rs4713142 chr6:28106347 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.14 -0.31 2.1e-15 Parkinson's disease; BRCA cis rs7666738 0.830 rs6532724 chr4:99060993 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.22e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7954584 0.567 rs1169071 chr12:122390084 G/T cg13699009 chr12:122356056 WDR66 0.36 8.27 0.31 7.85e-16 Mean corpuscular volume; BRCA cis rs11997175 0.740 rs4467902 chr8:33693415 G/T ch.8.33884649F chr8:33765107 NA 0.35 8.32 0.31 5.3e-16 Body mass index; BRCA cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg02297831 chr4:17616191 MED28 0.36 8.43 0.32 2.25e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs701145 0.640 rs1657621 chr3:153929795 T/C cg17054900 chr3:154042577 DHX36 0.52 8.9 0.33 5.83e-18 Coronary artery disease; BRCA cis rs3858526 0.523 rs10742818 chr11:5882535 T/C cg13902645 chr11:5959945 NA -0.49 -10.43 -0.38 1.24e-23 DNA methylation (variation); BRCA cis rs6121246 0.697 rs6060446 chr20:30231637 T/C cg21427119 chr20:30132790 HM13 -0.43 -9.06 -0.34 1.63e-18 Mean corpuscular hemoglobin; BRCA cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs11622475 1.000 rs11622475 chr14:104509076 C/T cg12183467 chr14:104352244 NA -0.46 -8.8 -0.33 1.28e-17 Bipolar disorder; BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.77 0.42 4.57e-29 Tonsillectomy; BRCA cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg18016565 chr1:150552671 MCL1 0.34 8.01 0.3 5.48e-15 Tonsillectomy; BRCA cis rs7582180 0.629 rs11123826 chr2:100936276 G/T cg08017756 chr2:100939284 LONRF2 0.29 7.83 0.3 2.09e-14 Intelligence (multi-trait analysis); BRCA cis rs60843830 1.000 rs3791224 chr2:221981 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.69 14.05 0.49 3.01e-39 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -9.12 -0.34 9.58e-19 Neuroticism; BRCA cis rs56104184 0.775 rs56317021 chr19:49395960 C/T cg21252483 chr19:49399788 TULP2 -0.51 -10.84 -0.39 2.92e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs208520 0.754 rs851593 chr6:66875783 C/T cg07460842 chr6:66804631 NA 1.0 18.64 0.59 2.99e-62 Exhaled nitric oxide output; BRCA cis rs4975616 0.869 rs370348 chr5:1331219 A/G cg07493874 chr5:1342172 CLPTM1L -0.51 -14.96 -0.51 1.27e-43 Lung cancer; BRCA cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 13.5 0.47 1.06e-36 Personality dimensions; BRCA cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.11 0.34 1.07e-18 Tonsillectomy; BRCA cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg13319975 chr6:146136371 FBXO30 -0.62 -14.5 -0.5 2.1e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs11577318 0.812 rs3795683 chr1:26632831 C/A cg00852783 chr1:26633632 UBXN11 0.5 10.96 0.4 9.94e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs1829883 0.835 rs2845982 chr5:98879638 C/A cg08333243 chr5:99726346 NA 0.36 8.37 0.31 3.64e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs4742903 0.935 rs17237053 chr9:106946359 C/T cg21169611 chr9:106856078 SMC2 -0.33 -8.23 -0.31 1.08e-15 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg13327785 chr12:132219529 SFRS8 -0.34 -8.01 -0.3 5.56e-15 Migraine; BRCA cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.79 0.48 4.68e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2267137 0.835 rs2267133 chr22:29765382 A/T cg07256473 chr22:29710276 RASL10A 0.36 8.94 0.33 4.15e-18 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs61931739 0.534 rs11052986 chr12:34052578 T/C cg26384229 chr12:38710491 ALG10B 0.51 11.26 0.41 5.83e-27 Morning vs. evening chronotype; BRCA cis rs883565 0.792 rs784498 chr3:39180099 A/G cg26331595 chr3:39149181 GORASP1;TTC21A -0.42 -8.87 -0.33 7.26e-18 Handedness; BRCA cis rs1401999 1.000 rs3805108 chr3:183691650 T/C cg01324343 chr3:183735012 ABCC5 0.81 20.44 0.63 8.24e-72 Anterior chamber depth; BRCA cis rs9494142 0.592 rs1547247 chr6:135390836 C/T cg22676075 chr6:135203613 NA 0.59 10.34 0.38 2.89e-23 Lymphocyte counts;Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs9858542 0.953 rs11711485 chr3:49491983 G/T cg21659725 chr3:3221576 CRBN -0.47 -9.91 -0.36 1.29e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7582180 0.629 rs11685406 chr2:100946638 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg19196401 chr6:110721138 DDO -0.41 -10.11 -0.37 2.1e-22 Platelet distribution width; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg04025307 chr7:1156635 C7orf50 0.58 11.4 0.41 1.51e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg18402987 chr7:1209562 NA 0.66 11.58 0.42 2.75e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg10560079 chr2:191398806 TMEM194B -0.36 -8.07 -0.3 3.5e-15 Pulse pressure; BRCA cis rs7927771 1.000 rs35624992 chr11:47615798 G/C cg18512352 chr11:47633146 NA -0.37 -9.13 -0.34 8.95e-19 Subjective well-being; BRCA cis rs2991971 1.000 rs2991971 chr1:46012748 C/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.34 -7.81 -0.3 2.28e-14 High light scatter reticulocyte count; BRCA trans rs12458462 0.892 rs3786228 chr18:77464170 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 0.46 8.65 0.32 4.09e-17 Monocyte count; BRCA cis rs7617773 0.817 rs3731534 chr3:48211777 C/T cg11946769 chr3:48343235 NME6 0.68 13.82 0.48 3.24e-38 Coronary artery disease; BRCA cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.67 17.31 0.57 2.4e-55 Age-related macular degeneration (geographic atrophy); BRCA cis rs10754283 0.967 rs2002883 chr1:90105838 A/G cg21401794 chr1:90099060 LRRC8C 0.46 11.13 0.4 2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.3e-15 Total body bone mineral density; BRCA cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg01745370 chr2:109065127 GCC2 0.42 10.14 0.37 1.66e-22 Mean platelet volume; BRCA cis rs1577917 1.000 rs12201735 chr6:86656939 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.89 -0.43 1.34e-29 Response to antipsychotic treatment; BRCA cis rs611744 0.647 rs6981420 chr8:109266694 T/G cg21045802 chr8:109455806 TTC35 0.35 7.99 0.3 6.42e-15 Dupuytren's disease; BRCA cis rs4919694 1.000 rs12242000 chr10:104702413 A/C cg04362960 chr10:104952993 NT5C2 0.97 15.09 0.51 3.25e-44 Arsenic metabolism; BRCA cis rs6942756 0.806 rs2566877 chr7:128897317 G/A cg02491457 chr7:128862824 NA 0.57 12.18 0.43 7.55e-31 White matter hyperintensity burden; BRCA trans rs61931739 0.500 rs10772160 chr12:34456848 G/A cg13010199 chr12:38710504 ALG10B 0.42 9.04 0.34 1.87e-18 Morning vs. evening chronotype; BRCA cis rs10752881 0.967 rs6695837 chr1:182991462 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.89 0.56 3.65e-53 Colorectal cancer; BRCA cis rs3768617 0.510 rs3768620 chr1:183092237 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.08e-57 Fuchs's corneal dystrophy; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg04013093 chr6:42928303 GNMT -0.28 -8.68 -0.32 3.16e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg26384229 chr12:38710491 ALG10B 0.85 22.52 0.67 3.94e-83 Heart rate; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg24846343 chr22:24311635 DDTL -0.49 -12.12 -0.43 1.42e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg25174290 chr11:3078921 CARS 0.42 12.65 0.45 6.73e-33 Longevity; BRCA cis rs10924970 0.870 rs7531130 chr1:235440556 C/G cg26050004 chr1:235667680 B3GALNT2 0.35 8.69 0.33 3.01e-17 Asthma; BRCA cis rs67311347 0.955 rs4974068 chr3:40376929 T/C cg09455208 chr3:40491958 NA 0.41 9.75 0.36 4.92e-21 Renal cell carcinoma; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.56 -0.39 3.98e-24 Lymphocyte counts; BRCA cis rs208520 0.690 rs12213561 chr6:66705646 T/C cg07460842 chr6:66804631 NA 0.97 19.47 0.61 1.26e-66 Exhaled nitric oxide output; BRCA cis rs17253792 0.731 rs74829671 chr14:56112759 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.14e-14 Putamen volume; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg22535103 chr8:58192502 C8orf71 -0.51 -8.66 -0.32 3.8e-17 Developmental language disorder (linguistic errors); BRCA cis rs2303759 0.958 rs1465697 chr19:49837246 C/T cg24324837 chr19:49891574 CCDC155 0.49 8.57 0.32 7.69e-17 Multiple sclerosis; BRCA cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs2880765 0.835 rs4536419 chr15:86039471 C/T cg10818794 chr15:86012489 AKAP13 -0.3 -8.43 -0.32 2.33e-16 Coronary artery disease; BRCA cis rs61931739 0.534 rs10506120 chr12:34235603 G/A cg06521331 chr12:34319734 NA -0.65 -11.92 -0.43 1.01e-29 Morning vs. evening chronotype; BRCA cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg26752003 chr8:145688521 CYHR1 0.54 13.18 0.46 2.82e-35 Age at first birth; BRCA cis rs9807989 0.507 rs4851004 chr2:103009537 A/G cg03938978 chr2:103052716 IL18RAP -0.3 -8.8 -0.33 1.29e-17 Asthma; BRCA cis rs4363385 0.747 rs6684188 chr1:152974285 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.33 -0.31 4.87e-16 Inflammatory skin disease; BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg04709771 chr16:646395 RAB40C 0.44 11.29 0.41 4.25e-27 Height; BRCA cis rs10782582 0.593 rs11579752 chr1:76178694 C/T cg10523679 chr1:76189770 ACADM -0.45 -8.03 -0.3 4.55e-15 Daytime sleep phenotypes; BRCA cis rs58785573 0.570 rs4833078 chr4:38646476 C/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.52 11.36 0.41 2.26e-27 Lymphocyte percentage of white cells; BRCA cis rs6570726 0.846 rs1935616 chr6:145943512 C/T cg23711669 chr6:146136114 FBXO30 0.71 16.97 0.56 1.38e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.920 rs1612097 chr1:76218875 C/T cg22875332 chr1:76189707 ACADM 0.66 15.64 0.53 6.65e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1712517 0.771 rs7074749 chr10:105116056 C/T cg05636881 chr10:105038444 INA 0.36 7.96 0.3 7.99e-15 Migraine; BRCA cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg22875332 chr1:76189707 ACADM 0.68 14.38 0.49 7.62e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9880211 0.948 rs17298525 chr3:136193025 G/C cg21827317 chr3:136751795 NA -0.45 -8.08 -0.3 3.17e-15 Body mass index;Height; BRCA cis rs1538970 1.000 rs11211101 chr1:45849311 C/G cg05343316 chr1:45956843 TESK2 0.59 12.36 0.44 1.31e-31 Platelet count; BRCA trans rs12310956 0.532 rs1525904 chr12:33962448 T/C cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs40363 0.645 rs1690446 chr16:3519009 T/C cg22508957 chr16:3507546 NAT15 0.42 9.44 0.35 6.65e-20 Tuberculosis; BRCA cis rs7267979 1.000 rs2258884 chr20:25279539 C/T cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg03354898 chr7:1950403 MAD1L1 -0.47 -9.32 -0.35 1.81e-19 Bipolar disorder and schizophrenia; BRCA cis rs4481887 0.927 rs12042598 chr1:248482016 C/T cg00666640 chr1:248458726 OR2T12 0.3 8.59 0.32 6.62e-17 Common traits (Other); BRCA cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg10523679 chr1:76189770 ACADM 0.77 18.64 0.59 2.94e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7945718 0.875 rs9888258 chr11:12782716 A/G cg25843174 chr11:12811716 TEAD1 0.23 8.76 0.33 1.8e-17 Educational attainment (years of education); BRCA cis rs4363385 0.765 rs3806221 chr1:153002555 G/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.83e-16 Inflammatory skin disease; BRCA cis rs9399135 0.967 rs6923827 chr6:135335382 C/T cg24558204 chr6:135376177 HBS1L 0.44 11.91 0.43 1.16e-29 Red blood cell count; BRCA cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg08859206 chr1:53392774 SCP2 0.45 9.88 0.36 1.56e-21 Monocyte count; BRCA cis rs1577917 0.545 rs9450325 chr6:86475814 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.34 9.31 0.35 2.09e-19 Response to antipsychotic treatment; BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg04944784 chr2:26401820 FAM59B 0.85 11.46 0.41 8.7e-28 Gut microbiome composition (summer); BRCA cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg24112000 chr20:60950667 NA -0.52 -9.87 -0.36 1.73e-21 Colorectal cancer; BRCA cis rs936229 0.861 rs7162232 chr15:75115895 G/A cg14664628 chr15:75095509 CSK -0.95 -29.22 -0.76 7.59e-120 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg26384229 chr12:38710491 ALG10B 0.74 17.17 0.56 1.24e-54 Bladder cancer; BRCA cis rs524281 0.861 rs7120326 chr11:65849256 C/T cg16950941 chr11:66035639 RAB1B -0.39 -8.29 -0.31 6.88e-16 Electroencephalogram traits; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 20.05 0.62 9.49e-70 Platelet count; BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg08999081 chr20:33150536 PIGU 0.47 12.95 0.46 3.15e-34 Glomerular filtration rate (creatinine); BRCA cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg24642439 chr20:33292090 TP53INP2 -0.41 -8.48 -0.32 1.6e-16 Glomerular filtration rate (creatinine); BRCA trans rs3960554 0.599 rs56090527 chr7:75762125 A/C cg19862616 chr7:65841803 NCRNA00174 0.61 12.65 0.45 6.84e-33 Eotaxin levels; BRCA cis rs11098499 0.754 rs12506487 chr4:120271361 T/G cg09307838 chr4:120376055 NA 0.6 12.94 0.46 3.6e-34 Corneal astigmatism; BRCA cis rs8028182 0.636 rs4886699 chr15:75692303 A/C cg20655648 chr15:75932815 IMP3 0.4 7.95 0.3 8.63e-15 Sudden cardiac arrest; BRCA cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg05347473 chr6:146136440 FBXO30 0.39 7.87 0.3 1.54e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs4730250 0.707 rs257385 chr7:106807448 T/C cg02696742 chr7:106810147 HBP1 -0.61 -9.6 -0.36 1.75e-20 Osteoarthritis; BRCA cis rs10504073 0.584 rs60449482 chr8:49974865 G/A cg00325661 chr8:49890786 NA 0.48 13.95 0.48 8.13e-39 Blood metabolite ratios; BRCA cis rs990171 0.607 rs10153578 chr2:102764609 C/T cg22835712 chr2:102737379 NA -0.54 -9.75 -0.36 5.03e-21 Lymphocyte counts; BRCA cis rs35740288 0.571 rs11629608 chr15:86330124 C/G cg20737812 chr15:86336631 KLHL25 -0.39 -9.49 -0.35 4.43e-20 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.05 -0.34 1.64e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs9942416 0.660 rs60423072 chr5:75006113 T/A cg19683494 chr5:74908142 NA 0.43 8.35 0.31 4.4e-16 Age-related disease endophenotypes; BRCA trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg08975724 chr8:8085496 FLJ10661 0.41 7.98 0.3 6.67e-15 Retinal vascular caliber; BRCA cis rs7020830 0.931 rs13295115 chr9:37157964 T/G cg14294708 chr9:37120828 ZCCHC7 1.19 37.4 0.83 4.71e-163 Schizophrenia; BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 17.75 0.57 1.36e-57 Alzheimer's disease; BRCA cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg12386194 chr3:101231763 SENP7 0.51 10.15 0.37 1.58e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs9463078 0.804 rs6458428 chr6:45179815 A/C cg25276700 chr6:44698697 NA -0.36 -8.09 -0.3 3e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg11890956 chr21:40555474 PSMG1 1.03 27.9 0.74 1.23e-112 Cognitive function; BRCA cis rs7584330 0.910 rs72620830 chr2:238396985 C/T cg14458575 chr2:238380390 NA 0.59 13.48 0.47 1.21e-36 Prostate cancer; BRCA cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg11645453 chr3:52864694 ITIH4 0.48 11.78 0.42 4.02e-29 Schizophrenia; BRCA cis rs4237845 0.816 rs61935769 chr12:58294344 G/A cg00677455 chr12:58241039 CTDSP2 0.55 12.33 0.44 1.73e-31 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA trans rs6762477 0.748 rs11711407 chr3:50225029 A/G cg21659725 chr3:3221576 CRBN -0.35 -8.51 -0.32 1.24e-16 Menarche (age at onset); BRCA cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg12011299 chr4:100065546 ADH4 0.42 11.11 0.4 2.33e-26 Alcohol dependence; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.24e-18 Tonsillectomy; BRCA cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg20203395 chr5:56204925 C5orf35 0.64 12.56 0.45 1.65e-32 Initial pursuit acceleration; BRCA cis rs17376456 0.542 rs10070350 chr5:93103753 C/G cg25358565 chr5:93447407 FAM172A 0.69 12.05 0.43 2.74e-30 Diabetic retinopathy; BRCA cis rs8040855 0.860 rs7172266 chr15:85716213 C/T cg04831495 chr15:85060580 GOLGA6L5 0.31 7.81 0.3 2.36e-14 Bulimia nervosa; BRCA cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg11764359 chr7:65958608 NA -0.73 -16.06 -0.54 5.08e-49 Aortic root size; BRCA cis rs826838 1.000 rs860400 chr12:39081279 A/G cg13010199 chr12:38710504 ALG10B -0.43 -9.88 -0.36 1.6e-21 Heart rate; BRCA cis rs3767633 0.925 rs4657103 chr1:161740483 G/T cg09175582 chr1:161736000 ATF6 0.5 8.31 0.31 5.76e-16 IgG glycosylation; BRCA cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg14835575 chr10:16859367 RSU1 0.56 11.87 0.42 1.74e-29 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs68170813 0.559 rs1989814 chr7:107045076 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.18 -0.31 1.58e-15 Coronary artery disease; BRCA cis rs7267979 0.966 rs454723 chr20:25438928 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.35 0.35 1.48e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17253792 0.822 rs10137364 chr14:56059987 G/A cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs9291683 0.546 rs4575994 chr4:9997979 G/A cg00071950 chr4:10020882 SLC2A9 0.46 10.83 0.39 3.42e-25 Bone mineral density; BRCA trans rs12310956 0.515 rs1872745 chr12:33985987 G/A cg26384229 chr12:38710491 ALG10B 0.51 11.03 0.4 4.98e-26 Morning vs. evening chronotype; BRCA cis rs11105298 0.891 rs10858871 chr12:89871613 G/A cg00757033 chr12:89920650 WDR51B 0.52 10.45 0.38 1.03e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2882667 0.690 rs13174008 chr5:138257909 T/C cg04439458 chr5:138467593 SIL1 -0.31 -7.93 -0.3 1.01e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2901460 0.509 rs11125898 chr2:62079895 T/C cg02183531 chr2:62113199 CCT4 -0.44 -8.77 -0.33 1.63e-17 Mean corpuscular volume; BRCA cis rs6582630 0.555 rs10880544 chr12:38473464 G/C cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.88e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs2985684 0.846 rs11157693 chr14:50048426 T/C cg04989706 chr14:50066350 PPIL5 -0.47 -9.21 -0.34 4.76e-19 Carotid intima media thickness; BRCA trans rs11098499 0.569 rs10023641 chr4:120258410 C/G cg25214090 chr10:38739885 LOC399744 0.43 10.16 0.37 1.43e-22 Corneal astigmatism; BRCA cis rs9902453 0.904 rs12939344 chr17:28328819 C/G cg26525008 chr17:28256777 EFCAB5;SSH2 -0.55 -14.22 -0.49 4.52e-40 Coffee consumption (cups per day); BRCA cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA cis rs1348850 0.914 rs10170546 chr2:178248790 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.9 0.36 1.31e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8177179 0.967 rs4443173 chr3:133439378 A/G cg16262614 chr3:133464971 TF 0.25 7.91 0.3 1.14e-14 Iron status biomarkers (transferrin levels); BRCA cis rs12497850 0.931 rs28642807 chr3:48926816 A/G cg07636037 chr3:49044803 WDR6 0.96 27.96 0.74 5.73e-113 Parkinson's disease; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.72 15.81 0.53 9.56e-48 Lymphocyte counts; BRCA cis rs4664304 0.620 rs2556086 chr2:160708446 G/T cg01092293 chr2:160761427 LY75 -0.32 -7.89 -0.3 1.3e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs35110281 0.720 rs162380 chr21:44925283 T/C cg01579765 chr21:45077557 HSF2BP 0.39 9.97 0.37 7.42e-22 Mean corpuscular volume; BRCA cis rs2832077 0.943 rs4816336 chr21:30193519 C/T cg24692254 chr21:30365293 RNF160 -0.46 -8.06 -0.3 3.82e-15 Cognitive test performance; BRCA cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg05896524 chr21:47604654 C21orf56 -0.42 -8.22 -0.31 1.17e-15 Testicular germ cell tumor; BRCA cis rs727479 0.502 rs2289105 chr15:51507508 C/T cg19946085 chr15:51559439 CYP19A1 0.31 8.57 0.32 7.5e-17 Estradiol levels; BRCA cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg02659138 chr7:134003124 SLC35B4 0.32 10.14 0.37 1.65e-22 Mean platelet volume; BRCA cis rs2580764 0.632 rs2588510 chr2:55199248 A/G cg09592903 chr2:55203963 RTN4 -0.42 -10.66 -0.39 1.53e-24 Mean platelet volume; BRCA cis rs3820928 1.000 rs6723774 chr2:227770592 C/T cg11843606 chr2:227700838 RHBDD1 0.4 8.87 0.33 7.2e-18 Pulmonary function; BRCA cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg11952622 chr19:58962976 ZNF324B 0.43 8.7 0.33 2.71e-17 Uric acid clearance; BRCA cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg16405210 chr4:1374714 KIAA1530 0.91 20.58 0.63 1.37e-72 Longevity; BRCA cis rs3213545 0.700 rs2260399 chr12:121469653 C/T cg02403541 chr12:121454288 C12orf43 0.55 11.82 0.42 2.8e-29 Subjective well-being;Cardiovascular disease risk factors; BRCA cis rs8177179 0.967 rs4287912 chr3:133437778 A/G cg16262614 chr3:133464971 TF 0.24 7.98 0.3 7e-15 Iron status biomarkers (transferrin levels); BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 19.08 0.6 1.46e-64 Platelet count; BRCA cis rs6570726 0.935 rs408723 chr6:145838535 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.71e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs62012628 0.527 rs12438008 chr15:79084680 C/T cg22753661 chr15:79092743 ADAMTS7 -0.4 -8.39 -0.32 3.02e-16 Diastolic blood pressure; BRCA cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg01236616 chr12:121019343 POP5 1.24 27.85 0.74 2.17e-112 Type 1 diabetes nephropathy; BRCA cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg03351412 chr1:154909251 PMVK 0.57 12.99 0.46 2.2e-34 Prostate cancer; BRCA trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg06636001 chr8:8085503 FLJ10661 0.52 11.39 0.41 1.8e-27 Recombination measurement; BRCA trans rs9858542 0.953 rs6809216 chr3:49412559 G/A cg21659725 chr3:3221576 CRBN -0.45 -9.86 -0.36 1.94e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs7980799 0.649 rs1601003 chr12:33689436 A/T cg26384229 chr12:38710491 ALG10B 0.52 11.03 0.4 5.14e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2762353 0.935 rs1185567 chr6:25818588 A/G cg12310025 chr6:25882481 NA -0.5 -12.1 -0.43 1.71e-30 Blood metabolite levels; BRCA cis rs7267979 0.932 rs1541061 chr20:25521057 G/A cg08601574 chr20:25228251 PYGB 0.35 8.39 0.32 3.06e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.517 rs7960878 chr12:34055645 C/A cg13010199 chr12:38710504 ALG10B 0.5 9.57 0.35 2.29e-20 Morning vs. evening chronotype; BRCA cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg18876405 chr7:65276391 NA 0.62 15.36 0.52 1.43e-45 Aortic root size; BRCA cis rs853679 0.517 rs35227624 chr6:28132726 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg04267008 chr7:1944627 MAD1L1 -0.6 -13.52 -0.47 8.46e-37 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.680 rs34267968 chr4:99002574 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg04709771 chr16:646395 RAB40C 0.43 10.99 0.4 7.78e-26 Height; BRCA cis rs73001065 0.536 rs10408596 chr19:19512657 A/T cg03709012 chr19:19516395 GATAD2A 1.04 15.4 0.52 9.25e-46 LDL cholesterol; BRCA cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg00684032 chr4:1343700 KIAA1530 0.33 8.29 0.31 6.63e-16 Obesity-related traits; BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.63 10.24 0.38 6.59e-23 Renal function-related traits (BUN); BRCA cis rs6743226 0.934 rs7565186 chr2:242249822 A/G cg10021735 chr2:242295487 FARP2 0.36 10.14 0.37 1.66e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs796364 0.951 rs281776 chr2:200834282 T/G cg23649088 chr2:200775458 C2orf69 0.55 8.01 0.3 5.58e-15 Schizophrenia; BRCA trans rs9291683 0.588 rs11732054 chr4:9999877 C/T cg26043149 chr18:55253948 FECH 0.41 8.91 0.33 5.34e-18 Bone mineral density; BRCA cis rs796364 1.000 rs281759 chr2:200787719 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.78 13.12 0.46 5.41e-35 Schizophrenia; BRCA trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg15704280 chr7:45808275 SEPT13 0.65 11.42 0.41 1.24e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg23708337 chr7:1209742 NA 0.42 7.96 0.3 8.1e-15 Longevity;Endometriosis; BRCA cis rs2204008 0.570 rs1315664 chr12:38138274 A/G cg26384229 chr12:38710491 ALG10B -0.46 -10.57 -0.39 3.71e-24 Bladder cancer; BRCA cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg21252483 chr19:49399788 TULP2 -0.51 -11.08 -0.4 3.1e-26 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs1775715 0.737 rs2808072 chr10:32205504 A/T cg14930904 chr10:32216787 ARHGAP12 0.34 7.94 0.3 9.14e-15 Bipolar disorder with mood-incongruent psychosis; BRCA trans rs11098499 0.820 rs28535956 chr4:120536858 C/T cg25214090 chr10:38739885 LOC399744 -0.57 -12.32 -0.44 1.86e-31 Corneal astigmatism; BRCA cis rs11605924 0.934 rs7945689 chr11:45879006 C/T ch.11.939596F chr11:45881766 CRY2 -0.47 -10.41 -0.38 1.56e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9287719 0.967 rs10929682 chr2:10732189 C/A cg02196655 chr2:10830764 NOL10 -0.3 -8.2 -0.31 1.35e-15 Prostate cancer; BRCA cis rs796364 0.616 rs6718118 chr2:200691852 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.51 -8.28 -0.31 7.15e-16 Schizophrenia; BRCA cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg12292205 chr6:26970375 C6orf41 0.64 14.45 0.5 3.77e-41 Autism spectrum disorder or schizophrenia; BRCA trans rs561341 1.000 rs483301 chr17:30293398 G/T cg20587970 chr11:113659929 NA -1.34 -24.49 -0.7 6.49e-94 Hip circumference adjusted for BMI; BRCA cis rs7178424 0.967 rs2162062 chr15:62279937 G/A cg00456672 chr15:62358751 C2CD4A -0.38 -8.77 -0.33 1.56e-17 Height; BRCA cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg00321850 chr1:175162397 KIAA0040 -0.41 -11.28 -0.41 4.85e-27 Alcohol dependence; BRCA cis rs1003719 0.680 rs2835630 chr21:38521842 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.37 -0.49 9.12e-41 Eye color traits; BRCA trans rs66887589 0.967 rs1155577 chr4:120449810 C/T cg25214090 chr10:38739885 LOC399744 -0.36 -8.34 -0.31 4.72e-16 Diastolic blood pressure; BRCA cis rs9815354 0.638 rs73071259 chr3:42001847 G/A cg03022575 chr3:42003672 ULK4 0.73 10.08 0.37 2.94e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs1003719 0.613 rs9978998 chr21:38535848 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.54 -0.5 1.43e-41 Eye color traits; BRCA cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.17 0.49 7.76e-40 Colorectal cancer; BRCA cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.89 -0.33 6.27e-18 Alzheimer's disease (late onset); BRCA cis rs4595586 0.545 rs2388176 chr12:39372357 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs9467773 0.620 rs3800303 chr6:26598188 A/G cg09904177 chr6:26538194 HMGN4 0.47 15.07 0.51 3.77e-44 Intelligence (multi-trait analysis); BRCA cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.38 0.49 8.14e-41 Colorectal cancer; BRCA cis rs7481584 0.603 rs399467 chr11:3072348 G/A cg08508325 chr11:3079039 CARS 0.29 8.69 0.33 3.09e-17 Calcium levels; BRCA cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg20503657 chr10:835505 NA 0.93 14.29 0.49 2.22e-40 Eosinophil percentage of granulocytes; BRCA cis rs1949733 0.701 rs2688222 chr4:8473735 C/A cg13073564 chr4:8508604 NA -0.37 -9.55 -0.35 2.76e-20 Response to antineoplastic agents; BRCA cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg05623727 chr3:50126028 RBM5 0.41 9.7 0.36 7.31e-21 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.822 rs74412558 chr14:56054311 C/T cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.37e-20 Putamen volume; BRCA cis rs6942407 0.546 rs4140847 chr7:86783263 A/T cg02420886 chr7:86849541 C7orf23 0.52 7.81 0.3 2.31e-14 Food allergy; BRCA cis rs2204008 0.527 rs8189480 chr12:38345648 C/T cg26384229 chr12:38710491 ALG10B -0.38 -8.82 -0.33 1.11e-17 Bladder cancer; BRCA cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.09 0.46 7.12e-35 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18402987 chr7:1209562 NA 0.61 12.94 0.46 3.45e-34 Longevity;Endometriosis; BRCA cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg19318889 chr4:1322082 MAEA 0.58 11.55 0.42 3.77e-28 Longevity; BRCA cis rs3741404 0.757 rs2282492 chr11:63918589 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 18.92 0.6 1.05e-63 Platelet count; BRCA cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.83 0.36 2.51e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs3820928 1.000 rs10193316 chr2:227777650 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.57 -0.32 7.7e-17 Pulmonary function; BRCA cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg20891283 chr12:69753455 YEATS4 -0.45 -11.43 -0.41 1.2e-27 Blood protein levels; BRCA cis rs17666538 0.585 rs336444 chr8:633123 C/G cg11416102 chr8:651193 ERICH1 -0.55 -7.92 -0.3 1.07e-14 IgG glycosylation; BRCA cis rs477895 0.653 rs11602181 chr11:63896591 C/G cg04317338 chr11:64019027 PLCB3 0.54 9.93 0.37 1e-21 Mean platelet volume; BRCA cis rs911119 0.779 rs3761280 chr20:23620076 A/G cg16589663 chr20:23618590 CST3 0.47 8.81 0.33 1.2e-17 Chronic kidney disease; BRCA cis rs12142240 0.698 rs66972124 chr1:46807445 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.2 0.31 1.37e-15 Menopause (age at onset); BRCA cis rs9467773 0.620 rs2504600 chr6:26648334 C/A cg11502198 chr6:26597334 ABT1 0.56 11.97 0.43 6.47e-30 Intelligence (multi-trait analysis); BRCA cis rs2860975 1.000 rs12781471 chr10:96765362 T/C cg09036531 chr10:96991505 NA -0.38 -8.18 -0.31 1.5e-15 Immune response to smallpox vaccine (IL-6); BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg16606324 chr3:10149918 C3orf24 0.52 10.03 0.37 4.4e-22 Alzheimer's disease; BRCA cis rs370915 0.542 rs1895844 chr4:187833759 C/T cg19519643 chr4:187840862 NA -0.37 -8.74 -0.33 2.05e-17 Gout; BRCA cis rs3784262 0.669 rs4646595 chr15:58302341 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.15 -0.37 1.46e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7587476 0.784 rs13008641 chr2:215698033 T/C cg04004882 chr2:215674386 BARD1 0.64 11.82 0.42 2.81e-29 Neuroblastoma; BRCA cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg10253484 chr15:75165896 SCAMP2 -0.48 -9.66 -0.36 1.06e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs79976124 0.837 rs75346757 chr6:66648386 A/T cg07460842 chr6:66804631 NA 0.6 10.27 0.38 5.29e-23 Type 2 diabetes; BRCA cis rs10911363 0.549 rs2794619 chr1:183459670 G/A cg09173681 chr1:183549694 NCF2 0.54 11.31 0.41 3.64e-27 Systemic lupus erythematosus; BRCA cis rs3617 0.652 rs60332615 chr3:52867595 C/A cg11645453 chr3:52864694 ITIH4 -0.38 -10.07 -0.37 3.03e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs218264 0.649 rs6554191 chr4:55374968 C/A cg17105814 chr4:55365203 NA -0.41 -8.32 -0.31 5.38e-16 Hemoglobin concentration;Hematocrit; BRCA cis rs79976124 0.837 rs10944858 chr6:66646039 G/A cg07460842 chr6:66804631 NA 0.6 10.31 0.38 3.59e-23 Type 2 diabetes; BRCA trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.53 0.47 7.42e-37 Morning vs. evening chronotype; BRCA cis rs2070488 0.804 rs2276541 chr3:38512779 G/A cg24069376 chr3:38537580 EXOG 0.34 9.36 0.35 1.36e-19 Electrocardiographic conduction measures; BRCA cis rs7178424 0.711 rs7166891 chr15:62239304 A/T cg00456672 chr15:62358751 C2CD4A 0.41 9.89 0.36 1.46e-21 Height; BRCA cis rs17021463 0.902 rs62320439 chr4:95248721 G/C cg11021082 chr4:95130006 SMARCAD1 0.38 7.98 0.3 6.56e-15 Testicular germ cell tumor; BRCA cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg02153584 chr22:29168773 CCDC117 0.53 11.12 0.4 2.18e-26 Lymphocyte counts; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs7737355 0.947 rs4706028 chr5:130946227 T/C cg06307176 chr5:131281290 NA 0.47 9.23 0.34 3.91e-19 Life satisfaction; BRCA cis rs11229555 0.609 rs12273517 chr11:58201094 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4919694 1.000 rs4917986 chr10:104630181 T/C cg04362960 chr10:104952993 NT5C2 0.83 13.37 0.47 4.2e-36 Arsenic metabolism; BRCA cis rs3768617 0.565 rs10752897 chr1:183071024 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.06 0.54 5.39e-49 Fuchs's corneal dystrophy; BRCA trans rs11098499 0.698 rs4422403 chr4:120258194 C/T cg25214090 chr10:38739885 LOC399744 0.44 10.23 0.38 7.36e-23 Corneal astigmatism; BRCA cis rs9814567 0.806 rs4074523 chr3:134325657 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.45 -0.32 1.99e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg00166722 chr3:10149974 C3orf24 0.63 12.77 0.45 2.08e-33 Alzheimer's disease; BRCA cis rs6723226 0.882 rs13035097 chr2:32836362 A/G cg02381751 chr2:32503542 YIPF4 -0.5 -10.28 -0.38 4.72e-23 Intelligence (multi-trait analysis); BRCA cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg20387954 chr3:183756860 HTR3D 0.35 8.26 0.31 8.22e-16 Anterior chamber depth; BRCA cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.49 -0.32 1.5e-16 Monocyte percentage of white cells; BRCA cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.6 12.07 0.43 2.28e-30 Multiple sclerosis; BRCA cis rs17401966 1.000 rs12755094 chr1:10305711 T/C cg03954927 chr1:10346856 KIF1B 0.43 12.7 0.45 4.3e-33 Hepatocellular carcinoma; BRCA cis rs10911251 0.528 rs10911266 chr1:183115097 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.22 0.54 7.92e-50 Colorectal cancer; BRCA cis rs7772486 0.806 rs4075695 chr6:146250959 A/G cg23711669 chr6:146136114 FBXO30 -0.66 -15.6 -0.53 9.98e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg13010199 chr12:38710504 ALG10B 0.53 11.07 0.4 3.38e-26 Heart rate; BRCA cis rs2075671 0.855 rs62483567 chr7:100286435 G/A cg20848291 chr7:100343083 ZAN -0.59 -12.64 -0.45 7.59e-33 Other erythrocyte phenotypes; BRCA cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg26528668 chr16:1614120 IFT140 0.36 8.19 0.31 1.43e-15 Coronary artery disease; BRCA cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg23033748 chr14:75592666 NEK9 0.39 9.5 0.35 3.97e-20 Height; BRCA cis rs4919694 1.000 rs12241091 chr10:104808997 G/A cg04362960 chr10:104952993 NT5C2 0.95 14.59 0.5 7.86e-42 Arsenic metabolism; BRCA cis rs17209837 0.607 rs1558376 chr7:87079103 T/A cg00919237 chr7:87102261 ABCB4 -0.53 -10.22 -0.37 8.0700000000000006e-23 Gallbladder cancer; BRCA cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg24450063 chr1:156163899 SLC25A44 -1.11 -36.21 -0.82 5.57e-157 Testicular germ cell tumor; BRCA cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg17330251 chr7:94953956 PON1 -0.42 -9.0 -0.34 2.53e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs17270561 0.636 rs7775354 chr6:25745266 T/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs1065852 0.526 rs7290655 chr22:42390225 C/G cg22189786 chr22:42395067 WBP2NL 0.43 8.59 0.32 6.7e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.84 0.42 2.32e-29 Tonsillectomy; BRCA cis rs838147 0.733 rs12978499 chr19:49237552 A/C cg12258179 chr19:49232187 RASIP1 0.33 8.17 0.31 1.61e-15 Dietary macronutrient intake; BRCA trans rs6089829 0.888 rs4809468 chr20:61673566 T/C cg23505145 chr19:12996616 KLF1 0.53 11.74 0.42 6.03e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs3755397 1 rs3755397 chr2:242294913 A/G cg03294028 chr2:242255774 SEPT2;HDLBP -0.68 -7.82 -0.3 2.13e-14 Chronic lymphocytic leukemia;Eosinophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells; BRCA cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs3741798 1.000 rs2160588 chr12:12487447 C/T cg08615371 chr12:12503544 MANSC1 1.03 15.38 0.52 1.26e-45 Cerebrospinal fluid biomarker levels; BRCA cis rs2153535 0.580 rs7766852 chr6:8472417 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.05 0.49 2.99e-39 Motion sickness; BRCA cis rs9309473 1.000 rs11899740 chr2:73631212 G/A cg20560298 chr2:73613845 ALMS1 -0.49 -11.96 -0.43 6.8e-30 Metabolite levels; BRCA trans rs11098499 0.954 rs11098526 chr4:120390359 C/T cg25214090 chr10:38739885 LOC399744 0.55 12.39 0.44 9.57e-32 Corneal astigmatism; BRCA cis rs1891275 0.515 rs1592051 chr10:93542186 A/G cg07889827 chr10:93443413 NA 0.4 11.12 0.4 2.25e-26 Intelligence (multi-trait analysis); BRCA cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.71 0.42 7.88e-29 Homoarginine levels; BRCA trans rs2562456 0.792 rs2562398 chr19:21722949 A/G cg25042112 chr7:64838748 ZNF92 0.45 8.4 0.32 2.97e-16 Pain; BRCA cis rs9470366 0.848 rs9470361 chr6:36623379 G/A cg08179530 chr6:36648295 CDKN1A 0.52 10.47 0.38 8.51e-24 QRS duration; BRCA cis rs2204008 0.870 rs12369578 chr12:38444227 C/T cg26384229 chr12:38710491 ALG10B 0.71 16.45 0.55 5.52e-51 Bladder cancer; BRCA cis rs35110281 0.666 rs9977076 chr21:45085829 G/A cg21573476 chr21:45109991 RRP1B -0.47 -12.5 -0.44 3.09e-32 Mean corpuscular volume; BRCA cis rs2652822 0.554 rs11635698 chr15:63478573 G/A cg02713581 chr15:63449717 RPS27L 0.43 8.61 0.32 5.87e-17 Metabolic traits; BRCA cis rs8062405 0.965 rs56040780 chr16:28861881 C/T cg09754948 chr16:28834200 ATXN2L 0.45 8.82 0.33 1.08e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7100689 0.784 rs7082102 chr10:82104890 A/C cg00277334 chr10:82204260 NA -0.43 -8.37 -0.31 3.72e-16 Post bronchodilator FEV1; BRCA trans rs11098499 1.000 rs58601355 chr4:120186367 T/C cg25214090 chr10:38739885 LOC399744 0.49 10.55 0.39 4.29e-24 Corneal astigmatism; BRCA cis rs921968 0.565 rs6436071 chr2:219598041 A/T cg02176678 chr2:219576539 TTLL4 -0.4 -11.0 -0.4 6.73e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg23788917 chr6:8435910 SLC35B3 0.49 10.69 0.39 1.17e-24 Motion sickness; BRCA cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg00825309 chr19:58991885 ZNF446 -0.57 -12.2 -0.43 6.55e-31 Uric acid clearance; BRCA trans rs629535 0.814 rs55873935 chr8:70081646 G/A cg21567404 chr3:27674614 NA -1.01 -21.49 -0.65 1.59e-77 Dupuytren's disease; BRCA cis rs6028335 0.610 rs72623594 chr20:37576255 G/A cg16355469 chr20:37678765 NA 0.45 8.0 0.3 5.94e-15 Alcohol and nicotine co-dependence; BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg00106254 chr7:1943704 MAD1L1 0.35 9.67 0.36 9.58e-21 Bipolar disorder and schizophrenia; BRCA cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg18225595 chr11:63971243 STIP1 -0.4 -10.07 -0.37 3.21e-22 Platelet count; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg13628971 chr7:2884303 GNA12 0.46 9.28 0.34 2.49e-19 Height; BRCA cis rs4713118 0.955 rs9393847 chr6:27687973 G/A cg20933634 chr6:27740509 NA 0.42 8.2 0.31 1.34e-15 Parkinson's disease; BRCA cis rs7927592 0.913 rs7109294 chr11:68332093 A/G cg20283391 chr11:68216788 NA -0.42 -8.45 -0.32 1.92e-16 Total body bone mineral density; BRCA cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg01448562 chr3:133502909 NA -0.76 -18.85 -0.6 2.21e-63 Iron status biomarkers; BRCA trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg11887960 chr12:57824829 NA 0.55 8.57 0.32 7.74e-17 Lung disease severity in cystic fibrosis; BRCA trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg26384229 chr12:38710491 ALG10B 0.67 14.29 0.49 2.1e-40 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg16339924 chr4:17578868 LAP3 0.76 19.09 0.6 1.32e-64 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3762637 1.000 rs72960431 chr3:122228661 T/C cg24169773 chr3:122142474 KPNA1 -0.43 -8.03 -0.3 4.75e-15 LDL cholesterol levels; BRCA cis rs611744 0.631 rs681963 chr8:109255032 C/A cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs870825 0.616 rs72705689 chr4:185639894 A/G cg04058563 chr4:185651563 MLF1IP 0.77 17.21 0.56 7.75e-55 Blood protein levels; BRCA cis rs7582180 0.764 rs12622318 chr2:100927375 T/C cg14675211 chr2:100938903 LONRF2 0.5 11.42 0.41 1.35e-27 Intelligence (multi-trait analysis); BRCA cis rs17601876 0.814 rs8029537 chr15:51557698 A/G cg19946085 chr15:51559439 CYP19A1 -0.38 -11.54 -0.42 4.02e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs8180040 0.620 rs56217494 chr3:47048452 T/G cg27129171 chr3:47204927 SETD2 -0.72 -17.3 -0.56 2.67e-55 Colorectal cancer; BRCA cis rs1865760 1.000 rs9393675 chr6:25930116 G/A cg17691542 chr6:26056736 HIST1H1C 0.52 10.47 0.38 8.91e-24 Height; BRCA cis rs2832191 0.791 rs7282843 chr21:30475226 A/G cg24692254 chr21:30365293 RNF160 0.66 18.2 0.58 5.71e-60 Dental caries; BRCA cis rs7493 0.755 rs13223537 chr7:94966167 C/T cg19678392 chr7:94953810 PON1 0.42 8.55 0.32 9.05e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg26608667 chr7:1196370 ZFAND2A 0.37 9.13 0.34 8.62e-19 Longevity;Endometriosis; BRCA cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg01448562 chr3:133502909 NA -0.41 -9.41 -0.35 8.84e-20 Iron status biomarkers; BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26314531 chr2:26401878 FAM59B -0.79 -12.74 -0.45 2.75e-33 Gut microbiome composition (summer); BRCA cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg13906792 chr15:75199810 C15orf17 -0.39 -9.18 -0.34 5.92e-19 Breast cancer; BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.93 0.33 4.64e-18 Tonsillectomy; BRCA trans rs7944735 0.507 rs7396592 chr11:48100837 T/C cg15704280 chr7:45808275 SEPT13 -0.44 -8.2 -0.31 1.32e-15 Intraocular pressure; BRCA cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg00750074 chr16:89608354 SPG7 -0.34 -9.02 -0.34 2.1e-18 Multiple myeloma (IgH translocation); BRCA cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.41e-15 Depression; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg24846343 chr22:24311635 DDTL -0.48 -11.76 -0.42 4.87e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg06108461 chr20:60628389 TAF4 -0.79 -16.84 -0.55 6.46e-53 Body mass index; BRCA cis rs6964587 1.000 rs7811564 chr7:91663364 A/G cg17063962 chr7:91808500 NA 0.53 12.43 0.44 6.26e-32 Breast cancer; BRCA cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg07636037 chr3:49044803 WDR6 0.46 9.23 0.34 3.96e-19 Resting heart rate; BRCA cis rs7917772 0.582 rs10786683 chr10:104320476 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.28 0.49 2.49e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs4714291 0.963 rs940352 chr6:40113614 C/T cg02267698 chr19:7991119 CTXN1 -0.42 -8.22 -0.31 1.14e-15 Strep throat; BRCA cis rs4594175 0.962 rs8008182 chr14:51608357 C/T cg23942311 chr14:51606299 NA 0.34 8.62 0.32 5.33e-17 Cancer; BRCA cis rs7766436 0.767 rs13206434 chr6:22608883 A/G cg13666174 chr6:22585274 NA -0.35 -8.2 -0.31 1.35e-15 Coronary artery disease; BRCA cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11890956 chr21:40555474 PSMG1 -0.54 -11.2 -0.41 1e-26 Menarche (age at onset); BRCA cis rs9814567 0.806 rs2293293 chr3:134322742 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.33 -7.95 -0.3 8.55e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg23711669 chr6:146136114 FBXO30 -0.77 -18.25 -0.59 3.5e-60 Lobe attachment (rater-scored or self-reported); BRCA trans rs66573146 1.000 rs6838250 chr4:6973184 C/G cg07817883 chr1:32538562 TMEM39B 1.4 18.96 0.6 6.48e-64 Granulocyte percentage of myeloid white cells; BRCA cis rs9814567 0.727 rs4543053 chr3:134351724 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.51 -16.12 -0.54 2.55e-49 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2304069 0.954 rs1433010 chr5:149383954 C/G cg10852222 chr5:149380144 HMGXB3;TIGD6 -0.57 -8.88 -0.33 6.9e-18 HIV-1 control; BRCA cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg20090143 chr19:45452003 APOC2 0.26 8.01 0.3 5.63e-15 Blood protein levels; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg03354898 chr7:1950403 MAD1L1 -0.47 -9.35 -0.35 1.42e-19 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.63 -0.32 4.99e-17 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg18230493 chr5:56204884 C5orf35 -0.73 -14.83 -0.51 5.96e-43 Initial pursuit acceleration; BRCA cis rs9611565 0.921 rs2143695 chr22:41728620 A/G cg19274703 chr22:41806451 NA 0.29 8.33 0.31 4.89e-16 Vitiligo; BRCA cis rs10267417 0.603 rs12666448 chr7:19859119 G/A cg05791153 chr7:19748676 TWISTNB 0.48 9.46 0.35 5.96e-20 Night sleep phenotypes; BRCA cis rs9324022 0.858 rs1004573 chr14:101178235 G/C cg18089426 chr14:101175970 NA 0.63 11.99 0.43 5.19e-30 Plateletcrit; BRCA cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.34 -0.35 1.52e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs965469 0.901 rs6037563 chr20:3326568 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -10.7 -0.39 1.07e-24 IFN-related cytopenia; BRCA trans rs561341 1.000 rs576985 chr17:30323323 C/T cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.26e-27 Hip circumference adjusted for BMI; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg23358479 chr7:1110784 C7orf50 -0.47 -7.9 -0.3 1.26e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg06636001 chr8:8085503 FLJ10661 0.68 15.43 0.52 7.16e-46 Mood instability; BRCA cis rs4363385 0.818 rs451939 chr1:153006877 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs4730250 0.707 rs10953537 chr7:107027905 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.66 -0.32 3.93e-17 Osteoarthritis; BRCA cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11644478 chr21:40555479 PSMG1 -0.65 -13.8 -0.48 4.09e-38 Cognitive function; BRCA cis rs861020 1.000 rs630984 chr1:209982293 C/T cg09163369 chr1:210001066 C1orf107 0.51 9.42 0.35 8.25e-20 Orofacial clefts; BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs9818758 0.607 rs10049462 chr3:49309684 C/T cg00383909 chr3:49044727 WDR6 0.75 12.18 0.43 7.55e-31 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.839 rs6949700 chr7:91467435 A/G cg17063962 chr7:91808500 NA 0.49 11.35 0.41 2.45e-27 Breast cancer; BRCA cis rs17641971 0.684 rs6984804 chr8:49987910 G/A cg00325661 chr8:49890786 NA 0.37 10.36 0.38 2.39e-23 Blood metabolite levels; BRCA cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.22 0.49 4.67e-40 Motion sickness; BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.36 -0.35 1.37e-19 Tonsillectomy; BRCA cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg22467129 chr15:76604101 ETFA -0.48 -10.76 -0.39 6.46e-25 Blood metabolite levels; BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg21747090 chr2:27597821 SNX17 -0.45 -9.65 -0.36 1.2e-20 Total body bone mineral density; BRCA cis rs9399401 0.710 rs7765770 chr6:142687305 C/T cg03128060 chr6:142623767 GPR126 0.31 7.85 0.3 1.77e-14 Chronic obstructive pulmonary disease; BRCA cis rs875971 0.505 rs6955582 chr7:65431686 A/G cg11764359 chr7:65958608 NA 0.61 13.45 0.47 1.75e-36 Aortic root size; BRCA cis rs6840360 0.571 rs55808836 chr4:152554991 C/T cg22705602 chr4:152727874 NA -0.34 -8.61 -0.32 5.47e-17 Intelligence (multi-trait analysis); BRCA cis rs6912958 0.516 rs242278 chr6:88047059 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.19 0.4 1.17e-26 Monocyte percentage of white cells; BRCA cis rs1475911 0.671 rs12483409 chr21:43521902 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.57 -12.86 -0.45 8.19e-34 IgG glycosylation; BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg08470875 chr2:26401718 FAM59B -0.64 -9.39 -0.35 1.03e-19 Gut microbiome composition (summer); BRCA cis rs208520 0.770 rs2153941 chr6:66885521 A/T cg07460842 chr6:66804631 NA -0.95 -17.75 -0.57 1.27e-57 Exhaled nitric oxide output; BRCA cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg01448562 chr3:133502909 NA -0.62 -14.81 -0.51 7.04e-43 Iron status biomarkers; BRCA cis rs1949733 0.656 rs2631762 chr4:8423122 A/T cg11789530 chr4:8429930 ACOX3 0.59 14.88 0.51 3.36e-43 Response to antineoplastic agents; BRCA cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg03354898 chr7:1950403 MAD1L1 -0.4 -8.03 -0.3 4.6e-15 Bipolar disorder and schizophrenia; BRCA cis rs372883 0.600 rs1153276 chr21:30661694 T/C cg08807101 chr21:30365312 RNF160 -0.42 -8.93 -0.33 4.36e-18 Pancreatic cancer; BRCA cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.17 0.31 1.62e-15 Axial length; BRCA cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg11890956 chr21:40555474 PSMG1 1.04 29.81 0.76 5.03e-123 Cognitive function; BRCA cis rs7772486 0.720 rs6901888 chr6:146023144 A/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.58 -0.32 7.4e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.62 -10.14 -0.37 1.7e-22 Alzheimer's disease; BRCA cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg21475434 chr5:93447410 FAM172A 0.71 9.09 0.34 1.27e-18 Diabetic retinopathy; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg14668821 chr17:77704760 ENPP7 -0.34 -7.88 -0.3 1.41e-14 Menopause (age at onset); BRCA cis rs6546550 0.867 rs726920 chr2:70152027 G/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.52 -0.41 5.13e-28 Prevalent atrial fibrillation; BRCA trans rs2562456 0.834 rs2173727 chr19:21673957 C/T cg25042112 chr7:64838748 ZNF92 0.42 8.11 0.31 2.57e-15 Pain; BRCA cis rs875971 0.895 rs4718349 chr7:65909011 C/G cg18876405 chr7:65276391 NA 0.55 13.18 0.46 3.03e-35 Aortic root size; BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg21724239 chr8:58056113 NA 0.57 9.24 0.34 3.72e-19 Developmental language disorder (linguistic errors); BRCA cis rs30380 1.000 rs30379 chr5:96122260 T/G cg16492584 chr5:96139282 ERAP1 -0.31 -7.95 -0.3 8.49e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs17376456 1.000 rs13154249 chr5:93550508 C/T cg25358565 chr5:93447407 FAM172A 1.16 18.09 0.58 2.26e-59 Diabetic retinopathy; BRCA cis rs7310409 0.544 rs1169292 chr12:121426478 C/T cg02403541 chr12:121454288 C12orf43 0.52 9.63 0.36 1.42e-20 Liver enzyme levels (gamma-glutamyl transferase);C-reactive protein;Pancreatic cancer; BRCA cis rs7395581 0.959 rs2167079 chr11:47270255 C/T cg25783544 chr11:47291846 MADD 0.38 8.38 0.31 3.38e-16 HDL cholesterol; BRCA cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg16145915 chr7:1198662 ZFAND2A 0.46 9.2 0.34 4.84e-19 Bronchopulmonary dysplasia; BRCA cis rs332507 0.830 rs879535 chr3:124400107 A/G cg05980111 chr3:124395277 KALRN 0.36 8.39 0.32 3.03e-16 Plateletcrit; BRCA cis rs6496044 0.568 rs7166642 chr15:86061271 A/G cg10818794 chr15:86012489 AKAP13 -0.28 -7.83 -0.3 1.98e-14 Interstitial lung disease; BRCA cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.12 0.43 1.42e-30 Mean platelet volume; BRCA cis rs4242434 0.819 rs6558173 chr8:22492103 A/C cg03733263 chr8:22462867 KIAA1967 -0.81 -18.99 -0.6 4.4e-64 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs1904096 0.506 rs12511433 chr4:95162425 G/A cg11021082 chr4:95130006 SMARCAD1 -0.41 -9.5 -0.35 4.01e-20 Type 2 diabetes; BRCA cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg12698349 chr2:225449008 CUL3 0.61 13.49 0.47 1.14e-36 IgE levels in asthmatics (D.p. specific); BRCA cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg15017067 chr4:17643749 FAM184B 0.31 9.56 0.35 2.49e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs365132 0.934 rs6861925 chr5:176324729 C/G cg16309518 chr5:176445507 NA -0.5 -12.78 -0.45 1.85e-33 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg19077165 chr18:44547161 KATNAL2 -0.53 -11.43 -0.41 1.17e-27 Personality dimensions; BRCA cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.96 14.06 0.49 2.6e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg03709012 chr19:19516395 GATAD2A -0.8 -18.34 -0.59 1.16e-60 Tonsillectomy; BRCA cis rs6867032 0.570 rs13166888 chr5:1982966 G/T cg26168224 chr5:2018326 NA -0.53 -11.91 -0.43 1.07e-29 Gut microbiome composition (winter); BRCA cis rs1878931 0.582 rs27232 chr16:3436782 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -9.57 -0.35 2.24e-20 Body mass index (adult); BRCA cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg08213375 chr14:104286397 PPP1R13B 0.51 11.13 0.4 2.09e-26 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg15017067 chr4:17643749 FAM184B 0.31 8.38 0.31 3.44e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs72781680 1.000 rs72796327 chr2:24140372 T/C cg20701182 chr2:24300061 SF3B14 0.68 10.04 0.37 4e-22 Lymphocyte counts; BRCA cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg17971929 chr21:40555470 PSMG1 0.8 18.62 0.59 3.74e-62 Cognitive function; BRCA cis rs11098499 0.644 rs6855918 chr4:120546299 C/T cg09307838 chr4:120376055 NA 0.59 12.12 0.43 1.43e-30 Corneal astigmatism; BRCA cis rs7715811 1.000 rs6554812 chr5:13762972 T/C cg07548982 chr5:13769939 DNAH5 -0.38 -8.33 -0.31 4.85e-16 Subclinical atherosclerosis traits (other); BRCA cis rs11105298 0.891 rs11105319 chr12:89927177 G/A cg00757033 chr12:89920650 WDR51B 0.54 10.87 0.39 2.31e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg25817165 chr18:72167213 CNDP2 -0.77 -19.53 -0.61 5.84e-67 Refractive error; BRCA cis rs9393777 0.513 rs9379893 chr6:26584668 A/G cg12292205 chr6:26970375 C6orf41 0.49 8.44 0.32 2.1e-16 Intelligence (multi-trait analysis); BRCA cis rs4563143 0.647 rs117442062 chr19:29256823 A/T cg03161606 chr19:29218774 NA 0.46 8.04 0.3 4.23e-15 Methadone dose in opioid dependence; BRCA cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg04455712 chr21:45112962 RRP1B 0.42 11.24 0.41 6.99e-27 Mean corpuscular volume; BRCA cis rs514406 0.683 rs6588440 chr1:53209587 C/T cg16325326 chr1:53192061 ZYG11B -0.91 -24.63 -0.7 1.09e-94 Monocyte count; BRCA cis rs589448 0.872 rs315111 chr12:69784695 G/A cg14784868 chr12:69753453 YEATS4 0.77 25.03 0.7 6.89e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs6964587 0.967 rs7788092 chr7:91646198 C/T cg17063962 chr7:91808500 NA 0.57 13.42 0.47 2.28e-36 Breast cancer; BRCA trans rs1005277 0.579 rs1780139 chr10:38503018 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.81 -0.45 1.36e-33 Extrinsic epigenetic age acceleration; BRCA trans rs6952808 1.000 rs6954673 chr7:1886937 C/T cg04565464 chr8:145669602 NFKBIL2 0.37 8.14 0.31 2.06e-15 Bipolar disorder and schizophrenia; BRCA cis rs6910061 1.000 rs28542236 chr6:11106966 T/C cg27233058 chr6:11094804 LOC221710 0.53 9.35 0.35 1.45e-19 Diabetic kidney disease; BRCA cis rs7903847 0.642 rs9888117 chr10:99159963 C/G cg08345082 chr10:99160200 RRP12 -0.28 -8.39 -0.32 3.06e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7809950 0.817 rs58052742 chr7:107210003 A/G cg23024343 chr7:107201750 COG5 0.46 9.45 0.35 6.21e-20 Coronary artery disease; BRCA cis rs2304069 0.817 rs216132 chr5:149431259 C/T cg12661370 chr5:149340060 SLC26A2 -0.51 -8.12 -0.31 2.39e-15 HIV-1 control; BRCA cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg03264133 chr6:25882463 NA 0.55 12.66 0.45 5.89e-33 Blood metabolite levels; BRCA cis rs7582180 0.701 rs11693044 chr2:100922313 T/C cg14675211 chr2:100938903 LONRF2 0.48 11.09 0.4 2.83e-26 Intelligence (multi-trait analysis); BRCA cis rs7520050 0.933 rs12565042 chr1:46299110 C/A cg24296786 chr1:45957014 TESK2 0.41 9.34 0.35 1.55e-19 Red blood cell count;Reticulocyte count; BRCA cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg24296786 chr1:45957014 TESK2 -0.39 -8.06 -0.3 3.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg26031613 chr14:104095156 KLC1 -0.44 -8.59 -0.32 6.45e-17 Schizophrenia; BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg12311346 chr5:56204834 C5orf35 -0.78 -15.97 -0.53 1.52e-48 Initial pursuit acceleration; BRCA cis rs11098499 0.955 rs11944880 chr4:120159334 A/G cg09307838 chr4:120376055 NA -0.59 -12.16 -0.43 9.03e-31 Corneal astigmatism; BRCA cis rs11874712 1.000 rs2298787 chr18:43669980 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs9287719 0.967 rs12464817 chr2:10707212 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.58e-15 Prostate cancer; BRCA cis rs2882667 0.858 rs13176497 chr5:138446074 T/C cg04439458 chr5:138467593 SIL1 -0.43 -10.75 -0.39 6.7e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg00166722 chr3:10149974 C3orf24 0.66 13.38 0.47 3.77e-36 Alzheimer's disease; BRCA cis rs1577917 1.000 rs1337850 chr6:86729103 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.06 -0.46 1.02e-34 Response to antipsychotic treatment; BRCA cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg05707623 chr12:122985044 ZCCHC8 0.5 9.66 0.36 1.02e-20 Body mass index; BRCA cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -9.94 -0.37 9.42e-22 Personality dimensions; BRCA cis rs1801251 0.778 rs809639 chr2:233731244 C/G cg25237894 chr2:233734115 C2orf82 0.44 14.19 0.49 6.04e-40 Coronary artery disease; BRCA cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.95 21.14 0.64 1.34e-75 Smoking behavior; BRCA cis rs78707713 0.535 rs3812705 chr10:71211146 A/G cg12610070 chr10:71211762 TSPAN15 -0.33 -11.67 -0.42 1.11e-28 Venous thromboembolism; BRCA cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg22875332 chr1:76189707 ACADM 0.66 15.64 0.53 6.25e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.23 0.38 7.21e-23 Calcium levels; BRCA cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24110177 chr3:50126178 RBM5 -0.42 -11.32 -0.41 3.39e-27 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.954 rs2389802 chr4:120325732 C/A cg09307838 chr4:120376055 NA 0.75 16.02 0.54 7.92e-49 Corneal astigmatism; BRCA cis rs11887277 0.684 rs2082610 chr2:27033440 G/A cg12368169 chr2:27073192 DPYSL5 -0.28 -7.82 -0.3 2.12e-14 Obesity-related traits; BRCA cis rs7666738 0.822 rs28512427 chr4:98919029 G/A cg17366294 chr4:99064904 C4orf37 0.41 9.63 0.36 1.39e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg05707623 chr12:122985044 ZCCHC8 -0.44 -8.75 -0.33 1.84e-17 Body mass index; BRCA cis rs60871478 1.000 rs62432252 chr7:802886 C/G cg04727924 chr7:799746 HEATR2 -0.53 -9.86 -0.36 1.95e-21 Cerebrospinal P-tau181p levels; BRCA cis rs6598955 0.627 rs7550127 chr1:26592871 C/T cg04990556 chr1:26633338 UBXN11 0.55 8.51 0.32 1.19e-16 Obesity-related traits; BRCA cis rs40363 0.951 rs250632 chr16:3523047 C/T cg21433313 chr16:3507492 NAT15 0.64 9.99 0.37 5.96e-22 Tuberculosis; BRCA trans rs4596713 0.538 rs7029627 chr9:71745687 C/T cg16512924 chr15:28394682 HERC2 0.4 9.45 0.35 6.24e-20 Headache; BRCA cis rs7572733 0.515 rs6726506 chr2:198846486 G/T cg00792783 chr2:198669748 PLCL1 0.44 9.68 0.36 8.7e-21 Dermatomyositis; BRCA cis rs7631605 0.905 rs6550456 chr3:37181995 A/G cg15934958 chr3:37212084 LRRFIP2 0.4 9.3 0.35 2.18e-19 Cerebrospinal P-tau181p levels; BRCA cis rs67311347 1.000 rs9865348 chr3:40397658 A/C cg09455208 chr3:40491958 NA 0.41 9.72 0.36 6.24e-21 Renal cell carcinoma; BRCA trans rs1974653 0.642 rs406086 chr22:20057806 C/T cg20152630 chr19:46405944 MYPOP 0.39 8.19 0.31 1.44e-15 Schizophrenia; BRCA cis rs3774749 0.565 rs2518795 chr3:50208819 C/T cg14019146 chr3:50243930 SLC38A3 -0.48 -11.65 -0.42 1.42e-28 Intelligence (multi-trait analysis); BRCA cis rs6138458 1.000 rs227658 chr20:24932028 A/G cg26195577 chr20:24973756 C20orf3 1.02 26.33 0.72 4.96e-104 Blood protein levels; BRCA cis rs7408868 1.000 rs10407320 chr19:15275716 G/C cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05901451 chr6:126070800 HEY2 0.39 9.6 0.36 1.76e-20 Endometrial cancer; BRCA cis rs79839061 0.610 rs2306252 chr4:892116 T/C cg14530993 chr4:882597 GAK 0.43 8.54 0.32 9.95e-17 Intelligence (multi-trait analysis); BRCA cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.68e-24 Motion sickness; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg21747090 chr2:27597821 SNX17 -0.44 -9.63 -0.36 1.32e-20 Total body bone mineral density; BRCA trans rs7824557 0.767 rs7003241 chr8:11169075 A/G cg08975724 chr8:8085496 FLJ10661 0.43 7.93 0.3 9.55e-15 Retinal vascular caliber; BRCA cis rs7044106 0.791 rs10984994 chr9:123478769 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.58 -12.3 -0.44 2.23e-31 Hip circumference adjusted for BMI; BRCA cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 22.0 0.66 2.67e-80 Chronic sinus infection; BRCA cis rs9790314 0.663 rs778653 chr3:160716041 G/T cg03342759 chr3:160939853 NMD3 -0.44 -9.09 -0.34 1.2e-18 Morning vs. evening chronotype; BRCA cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg16325326 chr1:53192061 ZYG11B 0.74 18.85 0.6 2.37e-63 Monocyte count; BRCA cis rs6570726 0.935 rs377130 chr6:145836632 C/T cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg17971929 chr21:40555470 PSMG1 -0.61 -13.4 -0.47 2.82e-36 Cognitive function; BRCA cis rs11958404 0.932 rs72816550 chr5:157418457 A/T cg05962755 chr5:157440814 NA 0.47 9.28 0.34 2.58e-19 IgG glycosylation; BRCA cis rs2204008 0.550 rs11495600 chr12:38126654 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA trans rs1945213 0.694 rs17149976 chr11:55839746 T/C cg03929089 chr4:120376271 NA 0.6 10.4 0.38 1.63e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs1707322 0.963 rs10890373 chr1:46393755 A/C cg03146154 chr1:46216737 IPP 0.49 10.69 0.39 1.15e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7178424 0.967 rs4143842 chr15:62373113 A/C cg00456672 chr15:62358751 C2CD4A -0.34 -8.19 -0.31 1.41e-15 Height; BRCA cis rs68170813 0.559 rs77605964 chr7:106962948 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.46 -0.32 1.82e-16 Coronary artery disease; BRCA cis rs17021463 0.966 rs1565062 chr4:95183000 G/A cg11021082 chr4:95130006 SMARCAD1 -0.42 -9.62 -0.36 1.56e-20 Testicular germ cell tumor; BRCA trans rs8073060 0.660 rs58266733 chr17:34003812 A/T cg19694781 chr19:47549865 TMEM160 -1.03 -21.11 -0.64 1.9e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs4819388 0.724 rs4818888 chr21:45645307 C/T cg17383793 chr5:52405638 MOCS2 0.48 10.75 0.39 6.56e-25 Celiac disease; BRCA cis rs1499972 0.941 rs6769144 chr3:117624517 C/T cg07612923 chr3:117604196 NA 0.6 8.1 0.31 2.86e-15 Schizophrenia; BRCA trans rs10838798 0.504 rs7479393 chr11:48295303 G/C cg15704280 chr7:45808275 SEPT13 -0.42 -8.19 -0.31 1.39e-15 Height; BRCA cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.47 0.38 9.08e-24 Motion sickness; BRCA cis rs7520050 0.931 rs7526678 chr1:46374159 A/G cg24296786 chr1:45957014 TESK2 0.43 9.85 0.36 2.18e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg07414643 chr4:187882934 NA 0.28 9.65 0.36 1.2e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.658 rs907181 chr8:8702875 T/C cg14343924 chr8:8086146 FLJ10661 0.36 7.93 0.3 9.79e-15 Mood instability; BRCA cis rs9287719 0.967 rs6733416 chr2:10738684 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.03 0.54 7.54e-49 Smoking behavior; BRCA trans rs11098499 0.821 rs28665282 chr4:120384186 C/T cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.84 0.42 2.32e-29 Tonsillectomy; BRCA cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7267979 1.000 rs2259956 chr20:25282433 A/G cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.63e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg26769984 chr7:1090371 C7orf50 0.47 8.88 0.33 6.91e-18 Bronchopulmonary dysplasia; BRCA cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg18404041 chr3:52824283 ITIH1 -0.29 -8.3 -0.31 6.35e-16 Electroencephalogram traits; BRCA cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg11812906 chr14:75593930 NEK9 0.65 15.01 0.51 7.86e-44 Height; BRCA cis rs1005277 0.579 rs932538 chr10:38381314 T/C cg25427524 chr10:38739819 LOC399744 -0.71 -17.4 -0.57 8.22e-56 Extrinsic epigenetic age acceleration; BRCA cis rs2180341 0.595 rs7771391 chr6:127749656 C/G cg24812749 chr6:127587940 RNF146 0.61 13.12 0.46 5.5800000000000005e-35 Breast cancer; BRCA cis rs3857067 0.806 rs7676797 chr4:95099194 G/A cg11021082 chr4:95130006 SMARCAD1 -0.38 -8.85 -0.33 8.85e-18 QT interval; BRCA cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 4.94e-18 Motion sickness; BRCA trans rs6461049 0.765 rs4719431 chr7:2140312 T/C cg04565464 chr8:145669602 NFKBIL2 0.42 10.28 0.38 4.87e-23 Schizophrenia; BRCA cis rs9646954 0.542 rs4149505 chr2:101033697 G/A cg08017756 chr2:100939284 LONRF2 -0.32 -8.14 -0.31 2.11e-15 Intelligence (multi-trait analysis); BRCA cis rs921968 0.541 rs12987171 chr2:219327030 G/C cg02176678 chr2:219576539 TTLL4 0.46 11.88 0.43 1.57e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs1209950 0.901 rs1209953 chr21:40180383 T/A cg01359822 chr21:40176597 ETS2 0.35 8.75 0.33 1.9e-17 Non-small cell lung cancer (survival); BRCA cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg13902645 chr11:5959945 NA -0.55 -11.16 -0.4 1.56e-26 DNA methylation (variation); BRCA cis rs2797160 1.000 rs2211420 chr6:125995549 A/G cg05901451 chr6:126070800 HEY2 -0.4 -9.68 -0.36 8.74e-21 Endometrial cancer; BRCA cis rs2046867 0.818 rs2208 chr3:72871773 A/G cg25664220 chr3:72788482 NA 0.41 9.24 0.34 3.7e-19 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs11718455 0.960 rs17076255 chr3:44002093 C/T cg08738300 chr3:44038990 NA 0.44 8.63 0.32 4.81e-17 Coronary artery disease; BRCA cis rs4363385 0.747 rs1415959 chr1:152973690 C/T cg21543102 chr1:152974771 SPRR3 0.29 8.45 0.32 1.91e-16 Inflammatory skin disease; BRCA cis rs7766436 1.000 rs13217022 chr6:22612757 T/C cg13666174 chr6:22585274 NA -0.39 -9.59 -0.35 1.97e-20 Coronary artery disease; BRCA cis rs2425143 1.000 rs6060588 chr20:34337480 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.95 -0.33 3.71e-18 Blood protein levels; BRCA cis rs2070433 0.706 rs55696586 chr21:47733918 T/C cg12379764 chr21:47803548 PCNT 0.54 9.14 0.34 8.47e-19 Lymphocyte counts; BRCA cis rs870825 0.616 rs28607131 chr4:185651617 A/G cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs1387259 0.929 rs11168484 chr12:48633589 A/C cg04545296 chr12:48745243 ZNF641 0.24 7.92 0.3 1.06e-14 Obstructive sleep apnea trait (apnea hypopnea index); BRCA cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg21573476 chr21:45109991 RRP1B -0.35 -9.3 -0.35 2.23e-19 Mean corpuscular volume; BRCA cis rs4561483 0.831 rs2018199 chr16:11940968 C/T cg08843971 chr16:11963173 GSPT1 -0.38 -8.2 -0.31 1.28e-15 Testicular germ cell tumor; BRCA cis rs7100689 0.646 rs7899791 chr10:82091950 A/T cg00277334 chr10:82204260 NA -0.43 -8.51 -0.32 1.2e-16 Post bronchodilator FEV1; BRCA cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg17971929 chr21:40555470 PSMG1 -0.47 -10.26 -0.38 5.59e-23 Menarche (age at onset); BRCA cis rs2011503 0.941 rs6511027 chr19:19391851 C/T cg11584989 chr19:19387371 SF4 0.58 13.72 0.48 9.99e-38 Bipolar disorder; BRCA cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg17420585 chr12:42539391 GXYLT1 -0.57 -14.32 -0.49 1.47e-40 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg11764359 chr7:65958608 NA -0.47 -9.28 -0.34 2.64e-19 Calcium levels; BRCA cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -7.86 -0.3 1.63e-14 Personality dimensions; BRCA cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg24642439 chr20:33292090 TP53INP2 0.54 11.56 0.42 3.43e-28 Glomerular filtration rate (creatinine); BRCA cis rs6964587 1.000 rs10234290 chr7:91716951 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.12 0.31 2.42e-15 Breast cancer; BRCA cis rs6964587 0.872 rs57969083 chr7:91665627 A/T cg17063962 chr7:91808500 NA 0.57 13.62 0.47 2.97e-37 Breast cancer; BRCA cis rs1707322 0.752 rs28812624 chr1:46203736 T/A cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg02297831 chr4:17616191 MED28 0.39 8.5 0.32 1.32e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7975161 0.671 rs7314893 chr12:104597769 C/T cg25273343 chr12:104657179 TXNRD1 -0.38 -9.26 -0.34 3.09e-19 Toenail selenium levels; BRCA cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg00745463 chr17:30367425 LRRC37B -0.57 -9.39 -0.35 1.01e-19 Hip circumference adjusted for BMI; BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.5 7.95 0.3 8.38e-15 Renal function-related traits (BUN); BRCA cis rs2732480 0.577 rs2732486 chr12:48737834 G/A cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 6.07e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs514406 0.668 rs520281 chr1:53365235 G/C cg27535305 chr1:53392650 SCP2 -0.5 -12.31 -0.44 2.08e-31 Monocyte count; BRCA cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg06108461 chr20:60628389 TAF4 -0.73 -15.53 -0.52 2.3e-46 Body mass index; BRCA cis rs7666738 0.546 rs13141117 chr4:98892798 G/A cg05340658 chr4:99064831 C4orf37 0.55 10.6 0.39 2.73e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg25801113 chr15:45476975 SHF -0.33 -7.94 -0.3 9.26e-15 Uric acid levels; BRCA cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg22974920 chr21:40686053 BRWD1 0.39 8.78 0.33 1.44e-17 Cognitive function; BRCA cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg01191920 chr7:158217561 PTPRN2 -0.41 -10.15 -0.37 1.48e-22 Obesity-related traits; BRCA cis rs10911251 0.546 rs20560 chr1:183105534 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.82 0.55 7.86e-53 Colorectal cancer; BRCA cis rs9467773 0.596 rs62396201 chr6:26668216 G/A cg11502198 chr6:26597334 ABT1 0.57 12.22 0.44 5.24e-31 Intelligence (multi-trait analysis); BRCA cis rs6484504 0.532 rs2150212 chr11:31255935 G/A cg14844989 chr11:31128820 NA -0.44 -9.54 -0.35 3.05e-20 Red blood cell count; BRCA cis rs875971 0.862 rs6460293 chr7:65810192 C/A cg18876405 chr7:65276391 NA -0.5 -11.18 -0.4 1.25e-26 Aortic root size; BRCA cis rs61990749 0.597 rs2267759 chr14:78147615 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.05 -0.37 3.59e-22 Fibroblast growth factor basic levels; BRCA cis rs3820928 0.605 rs2228555 chr2:227872995 C/T cg11843606 chr2:227700838 RHBDD1 0.49 11.32 0.41 3.45e-27 Pulmonary function; BRCA trans rs8073060 0.586 rs72829922 chr17:34044809 G/A cg19694781 chr19:47549865 TMEM160 1.07 20.64 0.63 6.34e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg05623727 chr3:50126028 RBM5 0.42 8.15 0.31 1.86e-15 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00166722 chr3:10149974 C3orf24 0.65 12.85 0.45 8.73e-34 Alzheimer's disease; BRCA trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg15704280 chr7:45808275 SEPT13 0.5 8.69 0.33 3.01e-17 Axial length; BRCA cis rs10197940 0.789 rs2444256 chr2:152280365 C/T cg19508488 chr2:152266495 RIF1 0.45 10.23 0.38 7.79e-23 Lung cancer; BRCA cis rs2832077 0.527 rs9980449 chr21:30224889 G/C cg24692254 chr21:30365293 RNF160 -0.52 -11.84 -0.42 2.19e-29 Cognitive test performance; BRCA cis rs68170813 0.559 rs75313693 chr7:106863170 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.47 -0.32 1.72e-16 Coronary artery disease; BRCA cis rs780096 0.546 rs715326 chr2:27725761 A/G cg12000995 chr2:27665139 KRTCAP3 0.33 8.38 0.31 3.44e-16 Total body bone mineral density; BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.95 17.45 0.57 4.5e-56 Gut microbiome composition (summer); BRCA cis rs7267979 0.932 rs449703 chr20:25458559 C/T cg08601574 chr20:25228251 PYGB 0.34 8.36 0.31 3.94e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1011018 0.590 rs77907480 chr7:139453119 T/C cg03224163 chr7:139420300 HIPK2 -0.59 -8.94 -0.33 4.27e-18 Systolic blood pressure; BRCA cis rs7633770 0.643 rs1581325 chr3:46691866 T/C cg11219411 chr3:46661640 NA -0.47 -11.07 -0.4 3.56e-26 Coronary artery disease; BRCA cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.72 13.99 0.48 5.45e-39 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs629535 0.821 rs660144 chr8:70035629 T/C cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.22e-75 Dupuytren's disease; BRCA cis rs1153858 1.000 rs7494956 chr15:45668565 T/C cg21132104 chr15:45694354 SPATA5L1 0.74 16.82 0.55 7.77e-53 Homoarginine levels; BRCA cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg11833968 chr6:79620685 NA -0.41 -9.16 -0.34 6.82e-19 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg08888203 chr3:10149979 C3orf24 -0.57 -11.95 -0.43 7.91e-30 Alzheimer's disease; BRCA cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg18876405 chr7:65276391 NA -0.63 -15.65 -0.53 5.63e-47 Aortic root size; BRCA cis rs9393777 0.557 rs36034627 chr6:27237363 G/T cg12292205 chr6:26970375 C6orf41 -0.65 -10.63 -0.39 2.02e-24 Intelligence (multi-trait analysis); BRCA cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -15.66 -0.53 5.08e-47 Asthma; BRCA cis rs919433 0.519 rs700656 chr2:198653667 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.16 0.37 1.35e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6750795 0.569 rs1667313 chr2:232408018 A/C cg19187155 chr2:232395269 NMUR1 0.69 17.51 0.57 2.31e-56 Height; BRCA cis rs1971762 0.583 rs11170648 chr12:54089660 C/T cg23533419 chr12:54090519 NA -0.33 -8.39 -0.31 3.22e-16 Height; BRCA cis rs4363385 0.818 rs679378 chr1:153011716 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.24 -0.34 3.56e-19 Inflammatory skin disease; BRCA cis rs858239 0.537 rs2286272 chr7:23224367 T/C cg23682824 chr7:23144976 KLHL7 0.34 8.73 0.33 2.28e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs4466137 0.904 rs6887104 chr5:83003535 G/A cg16102102 chr5:83017553 HAPLN1 -0.9 -18.33 -0.59 1.22e-60 Prostate cancer; BRCA cis rs35110281 0.774 rs162344 chr21:44954522 G/A cg21573476 chr21:45109991 RRP1B -0.35 -9.04 -0.34 1.85e-18 Mean corpuscular volume; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg09060608 chr5:178986726 RUFY1 -0.62 -16.39 -0.54 1.1e-50 Lung cancer; BRCA cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg13119609 chr19:45449297 APOC2 0.47 13.08 0.46 8.51e-35 Blood protein levels; BRCA cis rs2011503 0.509 rs73006705 chr19:19781917 A/G cg11584989 chr19:19387371 SF4 0.4 7.98 0.3 6.96e-15 Bipolar disorder; BRCA cis rs7927771 0.524 rs4752798 chr11:47886364 T/C cg20307385 chr11:47447363 PSMC3 -0.39 -9.29 -0.34 2.36e-19 Subjective well-being; BRCA cis rs2677744 0.626 rs11857545 chr15:91489705 G/A cg23684204 chr15:91497937 RCCD1 0.44 8.79 0.33 1.33e-17 Attention deficit hyperactivity disorder; BRCA cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg09658497 chr7:2847517 GNA12 -0.47 -10.47 -0.38 8.53e-24 Height; BRCA cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.74e-21 Colorectal cancer; BRCA cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg11952622 chr19:58962976 ZNF324B 0.39 8.25 0.31 9.18e-16 Uric acid clearance; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg03188948 chr7:1209495 NA 0.43 8.29 0.31 6.59e-16 Longevity;Endometriosis; BRCA cis rs1997103 1.000 rs4947501 chr7:55407342 C/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7044106 0.762 rs12003646 chr9:123470621 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.67 14.34 0.49 1.27e-40 Hip circumference adjusted for BMI; BRCA cis rs58785573 0.504 rs3860067 chr4:38611905 T/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.4 7.81 0.3 2.27e-14 Lymphocyte percentage of white cells; BRCA cis rs9486715 1.000 rs9486715 chr6:97059769 A/C cg06623918 chr6:96969491 KIAA0776 -0.84 -23.15 -0.68 1.44e-86 Headache; BRCA cis rs17401966 0.931 rs3737155 chr1:10459779 G/A cg03954927 chr1:10346856 KIF1B 0.47 14.07 0.49 2.34e-39 Hepatocellular carcinoma; BRCA cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg04450456 chr4:17643702 FAM184B 0.33 9.51 0.35 3.74e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7072216 0.763 rs7910247 chr10:100172252 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 9.24e-21 Metabolite levels; BRCA trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg03929089 chr4:120376271 NA 0.49 8.21 0.31 1.24e-15 Axial length; BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 8.96 0.33 3.58e-18 Tonsillectomy; BRCA cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg08999081 chr20:33150536 PIGU 0.49 13.91 0.48 1.22e-38 Coronary artery disease; BRCA cis rs11997175 0.766 rs4733178 chr8:33691899 A/T ch.8.33884649F chr8:33765107 NA 0.35 8.32 0.31 5.3e-16 Body mass index; BRCA cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs11711311 0.712 rs10804510 chr3:113340700 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.4 -8.59 -0.32 6.66e-17 IgG glycosylation; BRCA cis rs7191700 0.644 rs12149160 chr16:11439303 G/T cg00044050 chr16:11439710 C16orf75 -0.51 -12.17 -0.43 8.75e-31 Multiple sclerosis; BRCA cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg17971929 chr21:40555470 PSMG1 -0.62 -13.61 -0.47 3.22e-37 Cognitive function; BRCA cis rs56399783 0.901 rs11971014 chr7:2778444 C/T cg19731401 chr7:2775893 GNA12 0.48 8.29 0.31 6.48e-16 Childhood ear infection; BRCA cis rs4974559 0.739 rs28573879 chr4:1285910 C/T cg02980000 chr4:1222292 CTBP1 0.81 13.36 0.47 4.34e-36 Systolic blood pressure; BRCA cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg18876405 chr7:65276391 NA 0.5 11.26 0.41 5.79e-27 Aortic root size; BRCA cis rs10208940 0.920 rs7580719 chr2:68833572 A/G cg12452813 chr2:68675892 NA -0.5 -8.77 -0.33 1.57e-17 Urate levels in lean individuals; BRCA trans rs1422110 0.519 rs12055343 chr5:85437684 T/C cg01787110 chr1:109008453 NBPF6 0.4 8.66 0.32 3.94e-17 Attention function in attention deficit hyperactive disorder; BRCA cis rs1997103 1.000 rs6957984 chr7:55397331 G/A cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg18196295 chr10:418757 DIP2C -0.58 -13.59 -0.47 3.87e-37 Psychosis in Alzheimer's disease; BRCA cis rs78456975 1.000 rs6744743 chr2:1558161 C/T cg26248373 chr2:1572462 NA 0.46 9.03 0.34 2.08e-18 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg06064525 chr11:970664 AP2A2 -0.34 -10.0 -0.37 5.73e-22 Alzheimer's disease (late onset); BRCA cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg13010199 chr12:38710504 ALG10B 0.52 10.83 0.39 3.26e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs13046373 0.535 rs1911571 chr21:32031538 A/C cg16431978 chr21:31797932 KRTAP13-3 0.36 9.22 0.34 4.38e-19 HDL cholesterol; BRCA cis rs4845875 0.600 rs1889293 chr1:11840862 G/A cg24844545 chr1:11908347 NPPA 0.37 8.66 0.32 3.76e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs8028182 0.636 rs4886716 chr15:75856022 G/C cg20655648 chr15:75932815 IMP3 0.44 8.42 0.32 2.43e-16 Sudden cardiac arrest; BRCA cis rs3741151 0.773 rs79994237 chr11:73147974 T/C cg17517138 chr11:73019481 ARHGEF17 0.86 12.12 0.43 1.46e-30 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs6867032 0.687 rs4998338 chr5:2015910 A/G cg26168224 chr5:2018326 NA 0.64 17.74 0.57 1.49e-57 Gut microbiome composition (winter); BRCA cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg24006582 chr15:45444508 DUOX1 -0.56 -11.55 -0.42 3.82e-28 Uric acid levels; BRCA trans rs11098499 0.954 rs11098525 chr4:120390152 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.96 0.46 2.75e-34 Corneal astigmatism; BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg00149659 chr3:10157352 C3orf10 0.73 12.63 0.45 8.44e-33 Alzheimer's disease; BRCA cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg26597838 chr10:835615 NA 0.95 14.86 0.51 4.14e-43 Eosinophil percentage of granulocytes; BRCA cis rs6831352 0.734 rs3018046 chr4:100030388 C/T cg12011299 chr4:100065546 ADH4 0.42 10.56 0.39 3.96e-24 Alcohol dependence; BRCA cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg20503657 chr10:835505 NA 1.04 18.27 0.59 2.66e-60 Eosinophil percentage of granulocytes; BRCA cis rs68170813 0.559 rs12535258 chr7:106971050 T/C cg02696742 chr7:106810147 HBP1 -0.55 -9.02 -0.34 2.24e-18 Coronary artery disease; BRCA cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.43 0.57 5.6e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.818 rs407103 chr1:153007106 C/T cg25856811 chr1:152973957 SPRR3 0.31 8.32 0.31 5.34e-16 Inflammatory skin disease; BRCA cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg09184832 chr6:79620586 NA 0.48 10.63 0.39 2.1e-24 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg24642439 chr20:33292090 TP53INP2 -0.53 -11.47 -0.41 8.25e-28 Glomerular filtration rate (creatinine); BRCA cis rs1005224 0.889 rs2059382 chr14:76158916 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.33 -0.31 4.85e-16 Large artery stroke; BRCA cis rs7552404 0.731 rs931507 chr1:76401577 G/A cg03433033 chr1:76189801 ACADM -0.5 -9.9 -0.36 1.35e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7020830 0.931 rs7851239 chr9:37138672 A/G cg14294708 chr9:37120828 ZCCHC7 -1.01 -28.45 -0.75 1.13e-115 Schizophrenia; BRCA cis rs17095355 1.000 rs12247564 chr10:111721400 G/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.82 -0.36 2.69e-21 Biliary atresia; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg07092213 chr7:1199455 ZFAND2A -0.57 -12.81 -0.45 1.3e-33 Longevity;Endometriosis; BRCA cis rs6964587 0.839 rs10236107 chr7:91485461 G/A cg17063962 chr7:91808500 NA -0.52 -11.75 -0.42 5.13e-29 Breast cancer; BRCA cis rs80130819 0.515 rs917055 chr12:48385576 A/G cg05342945 chr12:48394962 COL2A1 -0.5 -9.62 -0.36 1.44e-20 Prostate cancer; BRCA cis rs9880211 0.898 rs9870825 chr3:136065720 C/A cg21827317 chr3:136751795 NA -0.46 -8.2 -0.31 1.36e-15 Body mass index;Height; BRCA cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg17971929 chr21:40555470 PSMG1 0.77 18.19 0.58 6.68e-60 Cognitive function; BRCA cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.9 0.36 1.36e-21 Bipolar disorder; BRCA cis rs8103278 1.000 rs11671524 chr19:46327166 G/A cg14061069 chr19:46274453 DMPK -0.48 -11.86 -0.42 1.84e-29 Coronary artery disease; BRCA cis rs754466 0.580 rs1054608 chr10:79543308 T/G cg17075019 chr10:79541650 NA -0.89 -24.82 -0.7 9.73e-96 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10746514 0.833 rs11122428 chr1:232261417 A/G cg09506761 chr1:232265262 NA -0.42 -8.64 -0.32 4.54e-17 Response to statin therapy; BRCA cis rs6835098 0.924 rs13125240 chr4:174151619 T/C cg08422745 chr4:174089978 GALNT7 0.83 15.61 0.53 8.91e-47 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1577917 1.000 rs7747824 chr6:86647106 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.38 -0.41 1.81e-27 Response to antipsychotic treatment; BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.87 0.53 4.82e-48 Platelet count; BRCA cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg06766960 chr11:133703094 NA -0.61 -12.93 -0.46 4.09e-34 Childhood ear infection; BRCA cis rs7246657 1.000 rs12709812 chr19:37794850 A/G cg18154014 chr19:37997991 ZNF793 -0.54 -10.05 -0.37 3.62e-22 Coronary artery calcification; BRCA cis rs35110281 0.667 rs4818859 chr21:45117120 G/A cg21573476 chr21:45109991 RRP1B -0.4 -10.34 -0.38 2.88e-23 Mean corpuscular volume; BRCA cis rs7766436 0.583 rs6939360 chr6:22557097 C/T cg13666174 chr6:22585274 NA -0.39 -7.85 -0.3 1.78e-14 Coronary artery disease; BRCA cis rs559928 0.606 rs57021319 chr11:63956102 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.61 0.42 2.17e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg08999081 chr20:33150536 PIGU 0.44 11.76 0.42 4.8e-29 Coronary artery disease; BRCA cis rs11764590 0.715 rs62444907 chr7:2083267 C/T cg02743256 chr7:2109353 MAD1L1 -0.46 -8.1 -0.31 2.78e-15 Neuroticism; BRCA cis rs9649465 0.967 rs13225110 chr7:123340849 C/T cg04330084 chr7:123175371 IQUB -0.32 -8.81 -0.33 1.21e-17 Migraine; BRCA cis rs12541635 1.000 rs1864320 chr8:107088979 C/T cg10147462 chr8:107024639 NA 0.3 8.44 0.32 2.19e-16 Age of smoking initiation; BRCA cis rs3806843 0.864 rs2531343 chr5:140129346 A/G cg26395211 chr5:140044315 WDR55 0.35 7.85 0.3 1.81e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs9443645 0.901 rs1542977 chr6:79550307 G/T cg18132916 chr6:79620363 NA -0.45 -10.35 -0.38 2.54e-23 Intelligence (multi-trait analysis); BRCA cis rs8062405 1.000 rs55719896 chr16:28846866 G/A cg16576597 chr16:28551801 NUPR1 0.3 8.44 0.32 2.14e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg06238570 chr21:40685208 BRWD1 -0.45 -8.83 -0.33 9.81e-18 Cognitive function; BRCA cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg12310025 chr6:25882481 NA -0.61 -13.48 -0.47 1.28e-36 Intelligence (multi-trait analysis); BRCA cis rs7662987 0.517 rs2851268 chr4:100027878 A/G cg12011299 chr4:100065546 ADH4 0.48 10.84 0.39 3.09e-25 Smoking initiation; BRCA cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg13736514 chr6:26305472 NA -0.36 -12.21 -0.43 5.69e-31 Educational attainment; BRCA cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg06115741 chr20:33292138 TP53INP2 0.35 7.89 0.3 1.29e-14 Glomerular filtration rate (creatinine); BRCA cis rs8017423 0.608 rs12588149 chr14:90822676 G/A cg04374321 chr14:90722782 PSMC1 -0.48 -11.73 -0.42 6.35e-29 Mortality in heart failure; BRCA cis rs861020 1.000 rs632746 chr1:209982515 C/T cg09163369 chr1:210001066 C1orf107 0.52 9.62 0.36 1.54e-20 Orofacial clefts; BRCA cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 27.89 0.74 1.38e-112 Chronic sinus infection; BRCA cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.85 0.39 2.76e-25 Cognitive ability; BRCA cis rs4363385 0.747 rs9919333 chr1:152968744 G/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.22 -0.31 1.17e-15 Inflammatory skin disease; BRCA cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14442939 chr10:27389572 ANKRD26 0.66 11.0 0.4 6.68e-26 Breast cancer; BRCA cis rs4363385 0.720 rs6672735 chr1:152981086 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.17e-18 Inflammatory skin disease; BRCA cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg26031613 chr14:104095156 KLC1 -0.45 -8.62 -0.32 5.1e-17 Schizophrenia; BRCA cis rs10754283 0.557 rs1215511 chr1:90087543 C/A cg21401794 chr1:90099060 LRRC8C 0.37 8.13 0.31 2.17e-15 Amyotrophic lateral sclerosis (sporadic); BRCA trans rs11039798 0.920 rs8186465 chr11:48796771 T/C cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs35995292 0.553 rs2392605 chr7:38924670 T/C cg19327137 chr7:38886074 VPS41 0.39 13.36 0.47 4.46e-36 Subjective well-being (multi-trait analysis); BRCA cis rs16866061 1.000 rs16866061 chr2:225439844 A/G cg12698349 chr2:225449008 CUL3 0.77 21.08 0.64 2.75e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs758324 0.947 rs13170693 chr5:131187826 T/C cg06307176 chr5:131281290 NA 0.53 10.27 0.38 5.49e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7918232 0.698 rs6482586 chr10:27297829 A/C cg14442939 chr10:27389572 ANKRD26 0.53 9.18 0.34 6.07e-19 Breast cancer; BRCA cis rs4906332 0.811 rs2756138 chr14:103996733 C/G cg04998671 chr14:104000505 TRMT61A 0.48 10.04 0.37 4.12e-22 Coronary artery disease; BRCA cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg24531977 chr5:56204891 C5orf35 0.52 10.87 0.4 2.2e-25 Coronary artery disease; BRCA cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg17366294 chr4:99064904 C4orf37 0.47 10.97 0.4 8.76e-26 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.658 rs12371956 chr12:38298010 A/T cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Bladder cancer; BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg03354898 chr7:1950403 MAD1L1 -0.59 -14.17 -0.49 7.65e-40 Bipolar disorder and schizophrenia; BRCA cis rs1801251 1.000 rs283468 chr2:233658309 C/T cg25237894 chr2:233734115 C2orf82 0.37 10.51 0.38 6.37e-24 Coronary artery disease; BRCA cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.06 -0.34 1.62e-18 Menopause (age at onset); BRCA cis rs78456975 0.527 rs4073862 chr2:1563433 A/G cg01028140 chr2:1542097 TPO -0.6 -12.54 -0.44 1.99e-32 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs870825 0.616 rs2090589 chr4:185647731 A/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs9814567 1.000 rs4498009 chr3:134198008 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.56 -0.32 8.35e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs8002861 0.870 rs2121030 chr13:44444574 C/T cg17145862 chr1:211918768 LPGAT1 -0.64 -16.46 -0.55 5.46e-51 Leprosy; BRCA cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg25801113 chr15:45476975 SHF 0.31 7.82 0.3 2.22e-14 Uric acid levels; BRCA cis rs4808199 0.947 rs7250658 chr19:19571100 A/G cg03709012 chr19:19516395 GATAD2A 1.08 20.92 0.64 1.98e-74 Nonalcoholic fatty liver disease; BRCA cis rs10752881 1.000 rs10752887 chr1:182990834 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.88 0.56 3.66e-53 Colorectal cancer; BRCA cis rs6942756 1.000 rs6980385 chr7:128943615 G/A cg02491457 chr7:128862824 NA -0.7 -13.72 -0.48 9.57e-38 White matter hyperintensity burden; BRCA cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg06484146 chr7:12443880 VWDE -0.75 -10.82 -0.39 3.54e-25 Coronary artery disease; BRCA cis rs735860 0.712 rs9395855 chr6:53176765 G/T cg10236188 chr6:53219634 NA -0.41 -8.92 -0.33 4.87e-18 Glaucoma; BRCA cis rs7520050 0.966 rs1707335 chr1:46571921 C/T cg24296786 chr1:45957014 TESK2 0.43 9.71 0.36 6.81e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4285028 0.948 rs12493408 chr3:121692119 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.88 -0.4 2.15e-25 Multiple sclerosis; BRCA cis rs208520 0.690 rs1351867 chr6:66760995 A/G cg07460842 chr6:66804631 NA 1.0 20.0 0.62 1.76e-69 Exhaled nitric oxide output; BRCA cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg03060546 chr3:49711283 APEH 0.41 9.08 0.34 1.31e-18 Menarche (age at onset); BRCA cis rs12291225 0.679 rs11369 chr11:14288096 A/G cg19336497 chr11:14380999 RRAS2 -0.46 -11.39 -0.41 1.64e-27 Sense of smell; BRCA cis rs8141529 0.748 rs132533 chr22:29299571 A/G cg02153584 chr22:29168773 CCDC117 -0.51 -10.46 -0.38 9.59e-24 Lymphocyte counts; BRCA cis rs4919694 1.000 rs17727391 chr10:104836101 C/A cg04362960 chr10:104952993 NT5C2 0.94 14.59 0.5 8.33e-42 Arsenic metabolism; BRCA cis rs654950 0.806 rs2759251 chr1:42041749 C/G cg06885757 chr1:42089581 HIVEP3 -0.3 -10.31 -0.38 3.8e-23 Airway imaging phenotypes; BRCA cis rs8077889 0.619 rs1230399 chr17:41845403 C/T cg26893861 chr17:41843967 DUSP3 -0.95 -24.92 -0.7 2.76e-96 Triglycerides; BRCA cis rs939658 0.805 rs1915726 chr15:79420620 C/G cg17916960 chr15:79447300 NA -0.45 -10.91 -0.4 1.53e-25 Refractive error; BRCA trans rs61931739 0.513 rs2200555 chr12:33899381 C/G cg13010199 chr12:38710504 ALG10B 0.37 8.12 0.31 2.49e-15 Morning vs. evening chronotype; BRCA cis rs7248779 0.532 rs10153475 chr19:2413961 G/C cg22729335 chr19:2427816 TIMM13 1.0 25.6 0.71 4.97e-100 Cortisol levels (saliva); BRCA cis rs881375 0.678 rs7031752 chr9:123663482 G/T cg03808351 chr9:123631620 PHF19 0.4 7.94 0.3 9.06e-15 Rheumatoid arthritis; BRCA cis rs6910061 1.000 rs9468412 chr6:11095876 C/T cg27233058 chr6:11094804 LOC221710 0.51 9.16 0.34 6.73e-19 Diabetic kidney disease; BRCA cis rs1344694 0.566 rs13029765 chr2:216894976 A/T cg12620499 chr2:216877984 MREG 0.55 14.18 0.49 7.16e-40 Alcohol dependence; BRCA trans rs12517041 1.000 rs10072527 chr5:23318246 A/T ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs722599 0.748 rs1059326 chr14:75369385 C/T cg08847533 chr14:75593920 NEK9 -0.44 -7.97 -0.3 7.19e-15 IgG glycosylation; BRCA cis rs4481887 0.927 rs4581306 chr1:248476158 C/A cg00666640 chr1:248458726 OR2T12 0.3 8.45 0.32 2e-16 Common traits (Other); BRCA cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg05283184 chr6:79620031 NA -0.43 -11.0 -0.4 6.58e-26 Intelligence (multi-trait analysis); BRCA cis rs3784262 0.669 rs4646579 chr15:58329528 G/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.3 -0.38 3.86e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs672059 1.000 rs510642 chr1:183162776 A/C ch.1.3577855R chr1:183094577 LAMC1 0.38 8.68 0.32 3.3e-17 Hypertriglyceridemia; BRCA cis rs4588572 0.643 rs13359053 chr5:77690224 T/C cg11547950 chr5:77652471 NA 0.44 7.82 0.3 2.21e-14 Triglycerides; BRCA cis rs3733585 0.699 rs6449174 chr4:9966422 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.16 -0.37 1.39e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs9325144 0.647 rs61937754 chr12:39060543 T/C cg23762105 chr12:34175262 ALG10 0.35 7.9 0.3 1.22e-14 Morning vs. evening chronotype; BRCA cis rs847577 0.572 rs847573 chr7:97681761 C/T cg24562669 chr7:97807699 LMTK2 -0.44 -10.41 -0.38 1.45e-23 Breast cancer; BRCA cis rs350251 0.899 rs350274 chr16:12233259 G/C cg06014057 chr16:12226852 SNX29 0.29 7.91 0.3 1.15e-14 Intelligence (multi-trait analysis); BRCA cis rs3784262 0.565 rs12595410 chr15:58293040 A/G cg12031962 chr15:58353849 ALDH1A2 0.32 8.4 0.32 2.91e-16 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg10729496 chr3:10149963 C3orf24 0.42 8.08 0.3 3.25e-15 Alzheimer's disease; BRCA cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs9811920 0.928 rs9865713 chr3:99870299 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 11.65 0.42 1.35e-28 Axial length; BRCA cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg08392591 chr16:89556376 ANKRD11 0.55 13.64 0.47 2.2e-37 Multiple myeloma (IgH translocation); BRCA cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.4 9.5 0.35 3.97e-20 Personality dimensions; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg13628971 chr7:2884303 GNA12 0.47 9.45 0.35 6.45e-20 Height; BRCA cis rs1997103 1.000 rs2331063 chr7:55408914 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg24296786 chr1:45957014 TESK2 -0.39 -8.13 -0.31 2.17e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs36051895 0.664 rs7852755 chr9:5100862 C/T cg02405213 chr9:5042618 JAK2 -0.52 -9.92 -0.37 1.17e-21 Pediatric autoimmune diseases; BRCA cis rs7555523 0.887 rs2251768 chr1:165738311 A/T cg24409356 chr1:165738333 TMCO1 0.5 8.27 0.31 7.87e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs7267979 1.000 rs2482943 chr20:25380593 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.3 -8.02 -0.3 5.19e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7584330 0.554 rs2325838 chr2:238386515 C/A cg14458575 chr2:238380390 NA 0.52 8.6 0.32 6.28e-17 Prostate cancer; BRCA cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.47 9.3 0.35 2.17e-19 Hemoglobin concentration; BRCA cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg13319975 chr6:146136371 FBXO30 0.39 8.93 0.33 4.54e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg23029597 chr12:123009494 RSRC2 -0.47 -9.56 -0.35 2.41e-20 Body mass index; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg23708337 chr7:1209742 NA 0.55 11.5 0.41 5.84e-28 Longevity;Endometriosis; BRCA cis rs559928 0.597 rs2186572 chr11:63895887 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.25 0.41 6.2e-27 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.57 -0.32 7.58e-17 Monocyte percentage of white cells; BRCA cis rs243505 1.000 rs243505 chr7:148435339 A/G cg09806900 chr7:148480153 CUL1 -0.39 -8.09 -0.3 3.07e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6912958 0.728 rs7773906 chr6:88251869 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.43 -0.32 2.26e-16 Monocyte percentage of white cells; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg03188948 chr7:1209495 NA 0.65 13.73 0.48 8.98e-38 Longevity;Endometriosis; BRCA cis rs798554 0.704 rs798531 chr7:2770067 G/C cg04166393 chr7:2884313 GNA12 0.4 8.26 0.31 8.2e-16 Height; BRCA cis rs4363385 0.747 rs11205149 chr1:152958840 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.34 -0.35 1.58e-19 Inflammatory skin disease; BRCA cis rs644148 0.730 rs2571044 chr19:44985573 G/A cg15540054 chr19:45004280 ZNF180 -0.5 -9.76 -0.36 4.61e-21 Personality dimensions; BRCA cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg01939980 chr4:1354348 KIAA1530 0.29 7.82 0.3 2.15e-14 Longevity; BRCA cis rs6028335 0.674 rs6028234 chr20:37607869 A/C cg16355469 chr20:37678765 NA 0.47 8.61 0.32 5.86e-17 Alcohol and nicotine co-dependence; BRCA cis rs9880211 0.898 rs28877020 chr3:136395716 T/G cg21827317 chr3:136751795 NA -0.45 -8.15 -0.31 1.92e-15 Body mass index;Height; BRCA trans rs6582630 0.502 rs1607876 chr12:38355750 T/C cg06521331 chr12:34319734 NA -0.45 -8.39 -0.32 3.11e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs11252926 0.507 rs4881199 chr10:428090 C/G cg18196295 chr10:418757 DIP2C 0.51 12.3 0.44 2.24e-31 Psychosis in Alzheimer's disease; BRCA cis rs11051970 0.659 rs950081 chr12:32588488 T/G cg02745156 chr12:32552066 NA 0.27 8.21 0.31 1.27e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs1707322 0.721 rs11211151 chr1:46112752 T/C cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs16958440 0.708 rs62096477 chr18:44662310 G/A cg17192377 chr18:44677553 HDHD2 0.49 8.3 0.31 6.37e-16 Sitting height ratio; BRCA cis rs13095912 1.000 rs2034344 chr3:185337788 T/C cg11274856 chr3:185301563 NA 0.34 8.38 0.31 3.3e-16 Systolic blood pressure; BRCA cis rs826838 0.616 rs4619214 chr12:38614704 C/A cg26384229 chr12:38710491 ALG10B 0.43 10.27 0.38 5.36e-23 Heart rate; BRCA cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg26384229 chr12:38710491 ALG10B -0.61 -14.7 -0.5 2.44e-42 Bladder cancer; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.69 13.96 0.48 7.58e-39 Gut microbiome composition (summer); BRCA cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.19e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9788721 0.836 rs2009746 chr15:78754102 A/G cg18825076 chr15:78729989 IREB2 -0.4 -8.26 -0.31 8.4e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg20503657 chr10:835505 NA 1.03 18.0 0.58 6.32e-59 Eosinophil percentage of granulocytes; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg04013093 chr6:42928303 GNMT -0.29 -8.86 -0.33 7.83e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11890956 chr21:40555474 PSMG1 -0.83 -21.32 -0.64 1.46e-76 Cognitive function; BRCA cis rs2153535 0.580 rs1319169 chr6:8464456 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.16 0.49 8.36e-40 Motion sickness; BRCA cis rs10751667 0.643 rs10751671 chr11:944479 T/G cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs7394190 0.748 rs2306327 chr10:75573778 A/T cg07699608 chr10:75541558 CHCHD1 0.67 10.06 0.37 3.47e-22 Incident atrial fibrillation; BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg08888203 chr3:10149979 C3orf24 0.57 10.26 0.38 5.51e-23 Alzheimer's disease; BRCA cis rs6545883 0.894 rs7572603 chr2:61552145 C/G cg15711740 chr2:61764176 XPO1 0.51 13.05 0.46 1.16e-34 Tuberculosis; BRCA cis rs17376456 1.000 rs13163610 chr5:93548877 A/C cg21475434 chr5:93447410 FAM172A 0.65 8.54 0.32 1.01e-16 Diabetic retinopathy; BRCA cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.6e-52 Bone mineral density; BRCA cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg12923728 chr3:195709715 SDHAP1 0.52 7.95 0.3 8.25e-15 Lung disease severity in cystic fibrosis; BRCA cis rs7666738 0.830 rs28867087 chr4:98880349 T/A cg17366294 chr4:99064904 C4orf37 0.42 9.76 0.36 4.45e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs9858542 0.537 rs115753735 chr3:49355005 T/C cg00383909 chr3:49044727 WDR6 0.45 9.62 0.36 1.47e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs7726839 1.000 rs7726839 chr5:618586 A/G cg25482853 chr8:67687455 SGK3 0.54 10.34 0.38 2.76e-23 Obesity-related traits; BRCA cis rs877282 0.583 rs7072970 chr10:822757 G/A cg15764593 chr10:829463 NA -0.64 -10.26 -0.38 6.01e-23 Uric acid levels; BRCA cis rs11690935 0.959 rs7355594 chr2:172639448 G/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.83 -0.77 1.4e-128 Schizophrenia; BRCA cis rs11190604 1.000 rs3793772 chr10:102222825 A/G cg07080220 chr10:102295463 HIF1AN 0.5 11.36 0.41 2.23e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 16.69 0.55 3.74e-52 Alzheimer's disease; BRCA cis rs1420338 0.933 rs10253869 chr7:34149922 A/G cg01275685 chr7:34179230 BMPER -0.46 -10.17 -0.37 1.3e-22 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg12311346 chr5:56204834 C5orf35 0.61 12.9 0.45 5.35e-34 Initial pursuit acceleration; BRCA cis rs12497850 0.863 rs4974084 chr3:48939080 G/A cg07636037 chr3:49044803 WDR6 0.98 28.98 0.75 1.45e-118 Parkinson's disease; BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -8.98 -0.33 3.01e-18 Intelligence (multi-trait analysis); BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg11584989 chr19:19387371 SF4 0.32 8.25 0.31 9.01e-16 Tonsillectomy; BRCA cis rs7254827 0.737 rs12982665 chr19:17158027 C/T cg19418318 chr19:17219073 MYO9B -0.48 -10.17 -0.37 1.29e-22 Mean platelet volume; BRCA cis rs7766436 0.885 rs3734215 chr6:22571323 T/C cg13666174 chr6:22585274 NA -0.48 -11.15 -0.4 1.62e-26 Coronary artery disease; BRCA cis rs1448094 0.512 rs12297441 chr12:86233980 C/T cg02569458 chr12:86230093 RASSF9 0.32 7.81 0.3 2.4e-14 Major depressive disorder; BRCA cis rs11098499 0.731 rs10015579 chr4:120271802 T/C cg09307838 chr4:120376055 NA 0.6 13.04 0.46 1.3e-34 Corneal astigmatism; BRCA cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.34 -10.77 -0.39 5.72e-25 Bipolar disorder; BRCA cis rs1215050 0.740 rs783938 chr4:99010336 A/T cg05340658 chr4:99064831 C4orf37 -0.48 -11.3 -0.41 3.9e-27 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg08975724 chr8:8085496 FLJ10661 -0.4 -7.84 -0.3 1.87e-14 Retinal vascular caliber; BRCA cis rs34172651 0.571 rs9922156 chr16:24704329 C/A cg00339695 chr16:24857497 SLC5A11 -0.36 -7.87 -0.3 1.57e-14 Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg11814155 chr7:99998594 ZCWPW1 0.59 10.08 0.37 2.82e-22 Platelet count; BRCA cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg11644478 chr21:40555479 PSMG1 0.85 19.81 0.62 1.89e-68 Cognitive function; BRCA cis rs2842992 0.789 rs2842969 chr6:160145364 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.66 16.84 0.55 6.09e-53 Age-related macular degeneration (geographic atrophy); BRCA cis rs6963495 0.818 rs73190202 chr7:105166510 A/G cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA cis rs1707322 0.928 rs10732844 chr1:46372688 T/C cg03146154 chr1:46216737 IPP 0.45 10.05 0.37 3.62e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 8.99 0.33 2.88e-18 Systemic lupus erythematosus; BRCA cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22509189 chr2:225307070 NA -0.44 -9.46 -0.35 5.9e-20 IgE levels in asthmatics (D.p. specific); BRCA cis rs875971 0.522 rs1968127 chr7:66056803 C/T cg18876405 chr7:65276391 NA -0.63 -15.56 -0.52 1.57e-46 Aortic root size; BRCA cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg08132940 chr7:1081526 C7orf50 -0.45 -8.12 -0.31 2.46e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs758324 0.947 rs6861732 chr5:131156462 A/C cg06307176 chr5:131281290 NA 0.53 10.33 0.38 3.07e-23 Alzheimer's disease in APOE e4- carriers; BRCA trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg11707556 chr5:10655725 ANKRD33B -0.41 -8.46 -0.32 1.87e-16 Coronary artery disease; BRCA cis rs782590 0.522 rs12329050 chr2:55894428 G/A cg18811423 chr2:55921094 PNPT1 -0.62 -17.44 -0.57 5.04e-56 Metabolic syndrome; BRCA trans rs6828577 0.626 rs17642633 chr4:119412100 A/G cg26518628 chr1:97050305 NA -0.45 -9.79 -0.36 3.39e-21 Perioperative myocardial infarction in coronary artery bypass surgery; BRCA trans rs7829975 0.688 rs7826654 chr8:8379106 C/T cg21775007 chr8:11205619 TDH 0.43 8.78 0.33 1.5e-17 Mood instability; BRCA cis rs7582180 0.700 rs2309852 chr2:100982527 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.59 0.42 2.61e-28 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg24642439 chr20:33292090 TP53INP2 0.43 9.14 0.34 8.2e-19 Height; BRCA cis rs679087 1.000 rs439639 chr12:29917641 A/C cg14258853 chr12:29935411 TMTC1 -0.42 -8.85 -0.33 8.36e-18 Schizophrenia; BRCA cis rs4930103 0.935 rs4930101 chr11:2021859 G/T cg06197492 chr11:2016605 H19 0.46 9.83 0.36 2.57e-21 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA trans rs9858542 0.953 rs9824092 chr3:49674147 C/G cg21659725 chr3:3221576 CRBN -0.49 -10.57 -0.39 3.56e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs10911232 0.507 rs10911230 chr1:183051118 A/C ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.71e-54 Hypertriglyceridemia; BRCA cis rs9309711 0.736 rs9678647 chr2:3497036 A/G cg16153549 chr2:3496821 NA 0.36 8.21 0.31 1.21e-15 Neurofibrillary tangles; BRCA trans rs7786808 0.608 rs9692003 chr7:158204696 G/A cg02030672 chr11:45687055 CHST1 -0.41 -9.11 -0.34 1.02e-18 Obesity-related traits; BRCA cis rs6025261 0.761 rs3848695 chr20:55513254 C/T cg04763273 chr20:55502381 NA 0.33 7.97 0.3 7.55e-15 Verbal memory performance (delayed recall level); BRCA cis rs66887589 0.934 rs6817317 chr4:120542827 A/G cg09307838 chr4:120376055 NA -0.44 -9.13 -0.34 8.96e-19 Diastolic blood pressure; BRCA cis rs8062405 1.000 rs56404918 chr16:28846840 T/G cg09754948 chr16:28834200 ATXN2L 0.47 9.17 0.34 6.53e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4561483 0.801 rs33620 chr16:12008546 C/G cg08843971 chr16:11963173 GSPT1 -0.52 -11.93 -0.43 8.99e-30 Testicular germ cell tumor; BRCA cis rs6088580 0.634 rs6120642 chr20:33012531 A/G cg08999081 chr20:33150536 PIGU 0.47 12.94 0.46 3.36e-34 Glomerular filtration rate (creatinine); BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg11905131 chr22:24372483 LOC391322 0.47 10.12 0.37 2.04e-22 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10751667 0.666 rs4074234 chr11:977715 C/G ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs13102973 0.933 rs7656595 chr4:135875693 G/A cg14419869 chr4:135874104 NA 0.51 10.86 0.39 2.42e-25 Subjective well-being; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.91 -20.05 -0.62 1.02e-69 Gut microbiome composition (summer); BRCA cis rs9486719 0.895 rs3734238 chr6:96996228 A/T cg06623918 chr6:96969491 KIAA0776 -0.78 -14.03 -0.49 3.69e-39 Migraine;Coronary artery disease; BRCA cis rs1868673 0.964 rs2167177 chr3:150135186 C/T cg04908077 chr3:150187338 NA -0.32 -8.66 -0.32 3.82e-17 Waist circumference; BRCA cis rs1448094 0.717 rs55811543 chr12:86290936 C/T cg19622623 chr12:86230825 RASSF9 -0.28 -7.99 -0.3 6.37e-15 Major depressive disorder; BRCA trans rs800082 0.668 rs9856190 chr3:144288547 G/C cg24215973 chr2:240111563 HDAC4 -0.42 -10.21 -0.37 8.98e-23 Smoking behavior; BRCA cis rs17376456 0.877 rs9314092 chr5:93326362 A/G cg21475434 chr5:93447410 FAM172A 0.66 8.56 0.32 8.21e-17 Diabetic retinopathy; BRCA trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg25482853 chr8:67687455 SGK3 1.05 16.92 0.56 2.29e-53 Lung disease severity in cystic fibrosis; BRCA cis rs11105298 0.891 rs8181784 chr12:89828591 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.46 -8.22 -0.31 1.17e-15 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg08470875 chr2:26401718 FAM59B -0.51 -8.3 -0.31 6.38e-16 Gut microbiome composition (summer); BRCA trans rs1973993 0.561 rs59429612 chr1:96988808 C/T cg10631902 chr5:14652156 NA -0.41 -10.12 -0.37 1.96e-22 Weight; BRCA cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg02175503 chr12:58329896 NA 0.42 8.09 0.3 3.03e-15 Intelligence (multi-trait analysis); BRCA cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg03452623 chr4:187889614 NA -0.35 -11.52 -0.41 4.83e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg10556349 chr10:835070 NA 0.61 8.44 0.32 2.08e-16 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs11941961 chr4:99065654 G/T cg05340658 chr4:99064831 C4orf37 0.67 16.6 0.55 1.05e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs2011503 0.509 rs10403579 chr19:19770329 T/C cg11584989 chr19:19387371 SF4 0.45 8.58 0.32 7.08e-17 Bipolar disorder; BRCA cis rs61931739 0.534 rs11053010 chr12:34093228 G/A cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.35e-26 Morning vs. evening chronotype; BRCA cis rs2346177 0.542 rs1900591 chr2:46697968 C/T cg02822958 chr2:46747628 ATP6V1E2 0.57 11.31 0.41 3.51e-27 HDL cholesterol; BRCA cis rs2304069 0.954 rs9324638 chr5:149400718 A/G cg12661370 chr5:149340060 SLC26A2 -0.54 -7.98 -0.3 6.68e-15 HIV-1 control; BRCA cis rs9560113 1.000 rs914026 chr13:112182029 G/A cg10483660 chr13:112241077 NA 0.32 7.83 0.3 2.02e-14 Menarche (age at onset); BRCA cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg24531977 chr5:56204891 C5orf35 0.65 14.42 0.5 4.88e-41 Initial pursuit acceleration; BRCA cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg01579765 chr21:45077557 HSF2BP -0.41 -10.53 -0.38 5.16e-24 Mean corpuscular volume; BRCA cis rs13118159 0.714 rs6843025 chr4:1334418 C/G cg01939980 chr4:1354348 KIAA1530 0.38 10.73 0.39 8.44e-25 Longevity; BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.96 -0.3 7.7e-15 Total body bone mineral density; BRCA cis rs701145 0.762 rs896014 chr3:153842691 A/G cg17054900 chr3:154042577 DHX36 0.54 9.08 0.34 1.36e-18 Coronary artery disease; BRCA cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg24812749 chr6:127587940 RNF146 0.66 14.91 0.51 2.21e-43 Breast cancer; BRCA cis rs1669338 0.507 rs4685607 chr3:3179400 C/T cg16797762 chr3:3221439 CRBN 0.7 10.87 0.39 2.35e-25 White matter integrity; BRCA cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 12.79 0.45 1.71e-33 Multiple sclerosis; BRCA cis rs7264396 0.790 rs11697903 chr20:34272224 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.96 -0.53 1.69e-48 Total cholesterol levels; BRCA cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg05084668 chr3:125655381 ALG1L -0.49 -9.24 -0.34 3.53e-19 Blood pressure (smoking interaction); BRCA cis rs60871478 1.000 rs67721251 chr7:825114 T/C cg04727924 chr7:799746 HEATR2 -0.54 -10.75 -0.39 6.98e-25 Cerebrospinal P-tau181p levels; BRCA cis rs68170813 0.559 rs17429146 chr7:106964281 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.9 -0.33 5.69e-18 Coronary artery disease; BRCA cis rs10911232 0.507 rs3934579 chr1:183027432 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.25e-51 Hypertriglyceridemia; BRCA cis rs4689388 0.926 rs10937719 chr4:6295322 C/G cg00701064 chr4:6280414 WFS1 0.68 17.22 0.56 7.14e-55 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -8.93 -0.33 4.51e-18 Monocyte percentage of white cells; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg04025307 chr7:1156635 C7orf50 0.56 13.15 0.46 3.85e-35 Longevity;Endometriosis; BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg00814883 chr7:100076585 TSC22D4 -0.52 -11.99 -0.43 4.88e-30 Platelet count; BRCA trans rs526821 0.595 rs624478 chr11:55340778 C/G cg11707556 chr5:10655725 ANKRD33B -0.36 -8.08 -0.3 3.15e-15 Pediatric bone mineral density (spine); BRCA cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.81 -0.36 2.89e-21 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.63e-33 Extrinsic epigenetic age acceleration; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg22963979 chr7:1858916 MAD1L1 -0.45 -9.06 -0.34 1.6e-18 Bipolar disorder and schizophrenia; BRCA cis rs13191362 1.000 rs13207239 chr6:163008772 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.97 0.46 2.69e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs826838 0.616 rs1601746 chr12:38626195 G/T cg26384229 chr12:38710491 ALG10B -0.42 -9.97 -0.37 7.28e-22 Heart rate; BRCA trans rs877282 0.583 rs10904566 chr10:821662 C/G cg22713356 chr15:30763199 NA 1.01 15.85 0.53 6.01e-48 Uric acid levels; BRCA cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg09035930 chr12:129282057 SLC15A4 0.58 17.51 0.57 2.2e-56 Systemic lupus erythematosus; BRCA cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.54 0.42 3.99e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.593 rs12340303 chr9:5176147 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.88 -0.33 6.6e-18 Pediatric autoimmune diseases; BRCA cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg16680214 chr1:154839983 KCNN3 -0.43 -11.98 -0.43 5.85e-30 Prostate cancer; BRCA cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg02187348 chr16:89574699 SPG7 0.5 11.75 0.42 5.34e-29 Multiple myeloma (IgH translocation); BRCA trans rs1493916 1.000 rs4393645 chr18:31394407 C/T cg27147174 chr7:100797783 AP1S1 -0.55 -11.06 -0.4 4.05e-26 Life satisfaction; BRCA cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg10792982 chr14:105748885 BRF1 -0.47 -10.62 -0.39 2.16e-24 Mean platelet volume;Platelet distribution width; BRCA cis rs7666738 0.830 rs13134216 chr4:98919765 C/T cg05340658 chr4:99064831 C4orf37 0.65 15.98 0.53 1.27e-48 Colonoscopy-negative controls vs population controls; BRCA cis rs61931739 0.500 rs7489132 chr12:34539712 C/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg21782813 chr7:2030301 MAD1L1 0.33 8.91 0.33 5.13e-18 Bipolar disorder and schizophrenia; BRCA cis rs17270561 0.636 rs7754814 chr6:25745243 A/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs7246657 0.550 rs10411176 chr19:37686953 G/T cg23950597 chr19:37808831 NA -0.66 -9.99 -0.37 6.41e-22 Coronary artery calcification; BRCA cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs7715811 1.000 rs1502041 chr5:13758529 A/G cg07548982 chr5:13769939 DNAH5 -0.38 -8.31 -0.31 5.85e-16 Subclinical atherosclerosis traits (other); BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg03354898 chr7:1950403 MAD1L1 -0.45 -9.16 -0.34 7.13e-19 Bipolar disorder and schizophrenia; BRCA cis rs13046373 0.507 rs2832969 chr21:32019627 A/G cg14062083 chr21:31802829 KRTAP13-4 0.34 9.18 0.34 6.13e-19 HDL cholesterol; BRCA cis rs853679 0.517 rs4713141 chr6:28101678 G/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.15 -0.31 1.99e-15 Depression; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.02 -0.34 2.09e-18 Menopause (age at onset); BRCA trans rs4596713 0.538 rs10125494 chr9:71770861 C/G cg16512924 chr15:28394682 HERC2 0.45 10.66 0.39 1.52e-24 Headache; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg18538332 chr22:24372958 LOC391322 -0.57 -14.39 -0.49 7.06e-41 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1400816 0.702 rs1850031 chr2:172557739 G/A cg13550731 chr2:172543902 DYNC1I2 0.54 8.48 0.32 1.56e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9649465 0.967 rs12537989 chr7:123308195 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.53e-16 Migraine; BRCA cis rs1707322 1.000 rs10890370 chr1:46389217 C/T cg06784218 chr1:46089804 CCDC17 0.44 10.28 0.38 4.94e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.65 15.69 0.53 3.71e-47 Chronic sinus infection; BRCA cis rs10464366 0.544 rs34866559 chr7:39166071 G/A cg18850127 chr7:39170497 POU6F2 0.55 12.09 0.43 1.99e-30 IgG glycosylation; BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg03609598 chr5:56110824 MAP3K1 -0.47 -8.14 -0.31 2.06e-15 Initial pursuit acceleration; BRCA cis rs12586317 0.547 rs10130773 chr14:35445299 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 8.71e-23 Psoriasis; BRCA cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg22862634 chr11:62369728 EML3;MTA2 0.57 13.69 0.48 1.4e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13136331 0.680 rs2732169 chr4:88656433 C/T cg22416721 chr4:88570574 DMP1 -0.56 -13.49 -0.47 1.15e-36 Sitting height ratio; BRCA cis rs10752881 1.000 rs4233192 chr1:182970837 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.63 -16.56 -0.55 1.62e-51 Colorectal cancer; BRCA trans rs61931739 0.534 rs11052983 chr12:34045787 C/A cg13010199 chr12:38710504 ALG10B 0.4 8.16 0.31 1.74e-15 Morning vs. evening chronotype; BRCA cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg18404041 chr3:52824283 ITIH1 -0.28 -8.36 -0.31 3.87e-16 Electroencephalogram traits; BRCA cis rs7824557 0.751 rs2099456 chr8:11127001 A/C cg21775007 chr8:11205619 TDH 0.55 11.17 0.4 1.4e-26 Retinal vascular caliber; BRCA cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg16339924 chr4:17578868 LAP3 0.63 15.68 0.53 4.2e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs782590 1.000 rs782594 chr2:55844445 T/C cg18811423 chr2:55921094 PNPT1 0.72 22.97 0.67 1.43e-85 Metabolic syndrome; BRCA cis rs9487051 0.773 rs351749 chr6:109533353 A/T cg01475377 chr6:109611718 NA -0.42 -10.54 -0.38 4.75e-24 Reticulocyte fraction of red cells; BRCA cis rs2806561 0.704 rs2868573 chr1:23508253 C/G cg12483005 chr1:23474871 LUZP1 0.46 10.27 0.38 5.48e-23 Height; BRCA cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg15017067 chr4:17643749 FAM184B -0.32 -10.0 -0.37 5.45e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 0.895 rs1833495 chr7:65921595 T/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg12927641 chr6:109611667 NA -0.42 -10.98 -0.4 8.52e-26 Reticulocyte fraction of red cells; BRCA trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg11707556 chr5:10655725 ANKRD33B -0.37 -8.71 -0.33 2.6e-17 Coronary artery disease; BRCA cis rs6598955 0.671 rs3924325 chr1:26616320 T/C cg00852783 chr1:26633632 UBXN11 -0.48 -8.1 -0.31 2.7e-15 Obesity-related traits; BRCA cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg00857998 chr1:205179979 DSTYK 0.44 8.31 0.31 5.72e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs8062405 1.000 rs62036626 chr16:28844284 A/G cg09754948 chr16:28834200 ATXN2L 0.46 9.13 0.34 9.04e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs523522 0.962 rs1050187 chr12:120902111 A/G cg27279351 chr12:120934652 DYNLL1 -0.57 -13.66 -0.48 1.83e-37 High light scatter reticulocyte count; BRCA cis rs10504229 0.565 rs7010503 chr8:58147127 G/A cg24829409 chr8:58192753 C8orf71 -0.43 -8.69 -0.33 3.03e-17 Developmental language disorder (linguistic errors); BRCA cis rs3809566 0.963 rs12148057 chr15:63331509 A/T cg05507819 chr15:63340323 TPM1 0.42 9.05 0.34 1.76e-18 Platelet count; BRCA cis rs9814567 1.000 rs9835204 chr3:134261342 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg11279151 chr3:101281821 RG9MTD1 -0.4 -8.64 -0.32 4.33e-17 Colorectal cancer; BRCA cis rs875971 0.577 rs35072105 chr7:65609817 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.41 -0.32 2.75e-16 Aortic root size; BRCA cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg09998033 chr7:158218633 PTPRN2 -0.39 -9.85 -0.36 2.16e-21 Obesity-related traits; BRCA cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg18016565 chr1:150552671 MCL1 0.35 8.1 0.31 2.71e-15 Melanoma; BRCA cis rs6782228 0.675 rs4857918 chr3:128383960 T/C cg16766828 chr3:128327626 NA -0.44 -9.67 -0.36 9.88e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA trans rs61931739 0.517 rs10844815 chr12:34245150 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.28 0.49 2.47e-40 Morning vs. evening chronotype; BRCA cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg03146154 chr1:46216737 IPP -0.45 -9.89 -0.36 1.53e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs9325144 0.600 rs2171405 chr12:38741030 G/T cg23762105 chr12:34175262 ALG10 0.36 8.45 0.32 2.02e-16 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.12e-23 Motion sickness; BRCA cis rs514406 0.525 rs269291 chr1:53189297 C/T cg24675658 chr1:53192096 ZYG11B -0.68 -14.66 -0.5 3.6e-42 Monocyte count; BRCA cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg20503657 chr10:835505 NA 1.03 18.28 0.59 2.43e-60 Eosinophil percentage of granulocytes; BRCA cis rs698813 0.674 rs3738985 chr2:44502788 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.78 0.33 1.53e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs4803468 1.000 rs284648 chr19:41926790 T/C cg09537434 chr19:41945824 ATP5SL -1.0 -23.64 -0.68 3e-89 Height; BRCA cis rs1448094 0.512 rs6539925 chr12:86244358 A/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.27 -0.34 2.75e-19 Major depressive disorder; BRCA cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.56 0.76 1.05e-121 Cognitive ability; BRCA cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.42e-68 Mean platelet volume; BRCA cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg17042849 chr6:26104293 HIST1H4C -0.46 -8.66 -0.32 3.86e-17 Iron status biomarkers; BRCA cis rs62380364 0.566 rs1705565 chr5:88048457 C/T cg22951263 chr5:87985283 NA -0.38 -10.78 -0.39 5.35e-25 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.929 rs2389272 chr12:34067771 T/C cg26384229 chr12:38710491 ALG10B -0.43 -10.15 -0.37 1.55e-22 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs7341381 chr6:8470537 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.84 0.33 9.45e-18 Motion sickness; BRCA cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg27624424 chr6:160112604 SOD2 0.4 8.25 0.31 8.99e-16 Age-related macular degeneration (geographic atrophy); BRCA trans rs34421088 0.576 rs2572432 chr8:11101723 A/G cg15556689 chr8:8085844 FLJ10661 -0.33 -8.0 -0.3 5.71e-15 Neuroticism; BRCA cis rs7267979 0.903 rs6115101 chr20:25229564 C/A cg08601574 chr20:25228251 PYGB 0.42 9.78 0.36 3.85e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4660306 1.000 rs4660306 chr1:45978675 C/T cg03123370 chr1:45965343 CCDC163P;MMACHC 0.39 7.92 0.3 1.09e-14 Homocysteine levels; BRCA cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg09184832 chr6:79620586 NA -0.49 -10.22 -0.37 7.86e-23 Intelligence (multi-trait analysis); BRCA cis rs7572733 0.534 rs1435570 chr2:198731371 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.2 0.37 9.44e-23 Dermatomyositis; BRCA cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg19318889 chr4:1322082 MAEA 0.5 10.63 0.39 2.08e-24 Longevity; BRCA cis rs1865760 0.964 rs9379802 chr6:25933898 T/A cg16482183 chr6:26056742 HIST1H1C 0.49 10.2 0.37 9.41e-23 Height; BRCA cis rs4713118 0.662 rs9468276 chr6:28027688 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs8177253 1.000 rs8177252 chr3:133480174 C/A cg12373951 chr3:133503437 NA 0.45 10.74 0.39 7.61e-25 Iron status biomarkers; BRCA cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg05313129 chr8:58192883 C8orf71 -0.46 -9.46 -0.35 5.73e-20 Developmental language disorder (linguistic errors); BRCA cis rs1829883 1.000 rs2461989 chr5:98793999 T/A cg08333243 chr5:99726346 NA -0.37 -8.97 -0.33 3.16e-18 Hemostatic factors and hematological phenotypes; BRCA trans rs1005277 0.557 rs2983338 chr10:38550734 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.2 -0.34 4.85e-19 Extrinsic epigenetic age acceleration; BRCA trans rs9858542 0.953 rs11926781 chr3:49603289 C/T cg21659725 chr3:3221576 CRBN -0.46 -9.82 -0.36 2.77e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs10504229 0.683 rs6980540 chr8:58127022 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.35 -0.38 2.52e-23 Reticulocyte count; BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg18402987 chr7:1209562 NA 0.71 12.15 0.43 1.07e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4319547 0.915 rs11058402 chr12:122981053 A/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.17 -0.37 1.33e-22 Body mass index; BRCA cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg00339695 chr16:24857497 SLC5A11 0.52 11.45 0.41 9.96e-28 Intelligence (multi-trait analysis); BRCA cis rs875971 0.520 rs12666485 chr7:65625122 T/C cg11764359 chr7:65958608 NA 0.65 11.9 0.43 1.21e-29 Aortic root size; BRCA cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg11845111 chr2:191398756 TMEM194B 0.42 9.41 0.35 8.81e-20 Pulse pressure; BRCA cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 13.89 0.48 1.68e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg00074818 chr8:8560427 CLDN23 0.38 8.27 0.31 7.99e-16 Obesity-related traits; BRCA cis rs7091068 0.671 rs1764322 chr10:95406276 T/G cg20715218 chr10:95462985 C10orf4 -0.47 -8.43 -0.32 2.24e-16 Urinary tract infection frequency; BRCA cis rs2880765 0.805 rs34598679 chr15:86042205 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.45 -0.32 1.92e-16 Coronary artery disease; BRCA cis rs1322639 1.000 rs9689079 chr6:169587148 A/G cg03254818 chr6:169586852 NA -0.4 -8.63 -0.32 5e-17 Pulse pressure; BRCA cis rs853679 0.517 rs35512245 chr6:28079953 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.26 -0.31 8.6e-16 Depression; BRCA cis rs6540556 0.635 rs17389184 chr1:209916789 C/T cg05527609 chr1:210001259 C1orf107 -0.5 -8.66 -0.32 3.87e-17 Red blood cell count; BRCA cis rs586533 0.781 rs594789 chr11:99498180 G/T cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg22875332 chr1:76189707 ACADM 0.7 14.5 0.5 2.23e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg05342945 chr12:48394962 COL2A1 -0.49 -9.84 -0.36 2.38e-21 Lung cancer; BRCA trans rs11098499 0.739 rs6534130 chr4:120131339 A/T cg25214090 chr10:38739885 LOC399744 -0.46 -9.87 -0.36 1.83e-21 Corneal astigmatism; BRCA trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.29 0.54 3.6e-50 Morning vs. evening chronotype; BRCA cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg24812749 chr6:127587940 RNF146 0.88 18.95 0.6 6.97e-64 Breast cancer; BRCA cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.21 -0.31 1.18e-15 Blood pressure (smoking interaction); BRCA cis rs7100689 0.646 rs7894762 chr10:82086779 C/G cg01528321 chr10:82214614 TSPAN14 0.81 17.21 0.56 8.09e-55 Post bronchodilator FEV1; BRCA cis rs72928364 1.000 rs13088524 chr3:100688082 A/C cg10123952 chr3:100791384 NA 0.53 7.89 0.3 1.3e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs11779988 0.545 rs448882 chr8:17794039 C/T cg01800426 chr8:17659068 MTUS1 -0.41 -8.35 -0.31 4.09e-16 Breast cancer; BRCA cis rs17376456 0.825 rs17372649 chr5:93126096 C/G cg25358565 chr5:93447407 FAM172A 1.16 18.02 0.58 4.93e-59 Diabetic retinopathy; BRCA cis rs7927771 0.800 rs12146565 chr11:47398963 G/A cg18512352 chr11:47633146 NA -0.34 -7.92 -0.3 1.03e-14 Subjective well-being; BRCA cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg20476274 chr7:133979776 SLC35B4 0.6 16.15 0.54 1.82e-49 Mean platelet volume; BRCA cis rs2304069 0.954 rs1469691 chr5:149386716 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.84 16.9 0.56 3.16e-53 HIV-1 control; BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg14062083 chr21:31802829 KRTAP13-4 0.35 9.58 0.35 2.03e-20 HDL cholesterol; BRCA cis rs3784262 0.669 rs12909423 chr15:58292433 C/G cg12031962 chr15:58353849 ALDH1A2 0.35 9.8 0.36 3.14e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11249608 0.548 rs7733072 chr5:178456007 A/G cg21905437 chr5:178450457 ZNF879 0.51 10.78 0.39 5.29e-25 Pubertal anthropometrics; BRCA cis rs897984 0.609 rs732173 chr16:31050023 C/A cg00531865 chr16:30841666 NA -0.4 -9.41 -0.35 9.15e-20 Dementia with Lewy bodies; BRCA cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg05283184 chr6:79620031 NA -0.44 -11.46 -0.41 8.63e-28 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.668 rs2409714 chr8:11010118 A/G cg15556689 chr8:8085844 FLJ10661 -0.31 -8.1 -0.31 2.84e-15 Triglycerides; BRCA cis rs6964587 1.000 rs1859113 chr7:91679887 T/C cg01689657 chr7:91764605 CYP51A1 0.21 7.82 0.3 2.14e-14 Breast cancer; BRCA cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.68 0.36 9.06e-21 Bipolar disorder; BRCA cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.74 -0.33 2.02e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6912958 0.781 rs4707379 chr6:88310623 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.32e-16 Monocyte percentage of white cells; BRCA cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg12011299 chr4:100065546 ADH4 0.51 11.73 0.42 6.44e-29 Alcohol dependence; BRCA cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg24399712 chr22:39784796 NA -0.57 -13.45 -0.47 1.72e-36 Intelligence (multi-trait analysis); BRCA trans rs7647973 0.626 rs1491985 chr3:49739507 G/C cg21659725 chr3:3221576 CRBN -0.48 -8.93 -0.33 4.35e-18 Menarche (age at onset); BRCA cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg05623727 chr3:50126028 RBM5 0.43 10.31 0.38 3.7e-23 Intelligence (multi-trait analysis); BRCA trans rs2727020 0.675 rs7929401 chr11:49350832 C/A cg03929089 chr4:120376271 NA -0.63 -11.51 -0.41 5.26e-28 Coronary artery disease; BRCA cis rs7592578 1.000 rs7592578 chr2:191439591 T/G cg27211696 chr2:191398769 TMEM194B 0.48 7.93 0.3 9.72e-15 Diastolic blood pressure; BRCA trans rs8073060 0.586 rs225303 chr17:33922149 A/G cg19694781 chr19:47549865 TMEM160 0.97 20.8 0.64 8.96e-74 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs11252926 0.550 rs10904148 chr10:454551 G/T cg18196295 chr10:418757 DIP2C 0.49 11.78 0.42 4.03e-29 Psychosis in Alzheimer's disease; BRCA cis rs2153535 0.504 rs9328472 chr6:8470848 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs9768139 0.708 rs36064654 chr7:158116632 C/T cg24154853 chr7:158122151 PTPRN2 0.33 7.81 0.3 2.32e-14 Calcium levels; BRCA cis rs11098499 0.955 rs13129661 chr4:120152909 C/G cg09307838 chr4:120376055 NA 0.6 11.62 0.42 1.91e-28 Corneal astigmatism; BRCA trans rs208515 0.525 rs10944871 chr6:66690306 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.88 16.91 0.56 2.78e-53 Exhaled nitric oxide levels; BRCA cis rs908922 0.651 rs1988805 chr1:152531495 T/G cg20991723 chr1:152506922 NA 0.36 8.13 0.31 2.18e-15 Hair morphology; BRCA cis rs9467773 1.000 rs4713008 chr6:26538268 T/C cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.722 rs28512414 chr19:38056574 T/A cg23950597 chr19:37808831 NA -0.5 -8.62 -0.32 5.36e-17 Coronary artery calcification; BRCA cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg04586622 chr2:25135609 ADCY3 0.44 10.98 0.4 8.31e-26 Body mass index; BRCA cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11644478 chr21:40555479 PSMG1 -0.54 -11.6 -0.42 2.38e-28 Menarche (age at onset); BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg27170947 chr2:26402098 FAM59B 0.63 11.15 0.4 1.7e-26 Gut microbiome composition (summer); BRCA cis rs8114671 0.967 rs9574 chr20:33764632 C/G cg07148914 chr20:33460835 GGT7 0.37 7.88 0.3 1.42e-14 Height; BRCA cis rs9790314 1.000 rs7638668 chr3:161047283 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.04 -0.49 3.32e-39 Morning vs. evening chronotype; BRCA trans rs1005277 0.505 rs10827836 chr10:38215441 A/G cg17830980 chr10:43048298 ZNF37B 0.42 9.97 0.37 7.49e-22 Extrinsic epigenetic age acceleration; BRCA cis rs4808199 0.649 rs12983940 chr19:19516431 G/A cg03709012 chr19:19516395 GATAD2A 1.11 21.25 0.64 3.35e-76 Nonalcoholic fatty liver disease; BRCA cis rs4953318 0.796 rs10168349 chr2:46360907 G/C cg12428440 chr2:46370979 PRKCE 0.41 9.54 0.35 2.93e-20 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs9814567 0.806 rs9841371 chr3:134320765 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg14863265 chr7:2801509 GNA12 -0.47 -10.2 -0.37 9.64e-23 Height; BRCA cis rs58235267 0.591 rs4671457 chr2:63346356 C/T cg17519650 chr2:63277830 OTX1 0.37 7.82 0.3 2.19e-14 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA trans rs1974653 0.781 rs9606241 chr22:20075858 A/G cg20152630 chr19:46405944 MYPOP 0.36 8.24 0.31 9.88e-16 Schizophrenia; BRCA cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg02659138 chr7:134003124 SLC35B4 0.32 9.78 0.36 3.79e-21 Mean platelet volume; BRCA cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -9.75 -0.36 5.01e-21 Glomerular filtration rate (creatinine); BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.49 0.57 2.78e-56 Alzheimer's disease; BRCA cis rs1865760 1.000 rs2071301 chr6:25914263 G/T cg16482183 chr6:26056742 HIST1H1C 0.53 11.08 0.4 3.21e-26 Height; BRCA cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.58 11.86 0.42 1.74e-29 Age-related macular degeneration (geographic atrophy); BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg23285459 chr7:2802560 GNA12 -0.35 -8.88 -0.33 6.84e-18 Height; BRCA cis rs4074536 0.574 rs10732297 chr1:116289054 C/T cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg27446573 chr6:127587934 RNF146 0.85 20.13 0.62 3.49e-70 Breast cancer; BRCA cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.46 0.38 9.81e-24 Bipolar disorder; BRCA cis rs1707322 1.000 rs785519 chr1:46568562 C/T cg03146154 chr1:46216737 IPP -0.43 -9.42 -0.35 8.22e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg09184832 chr6:79620586 NA -0.53 -11.87 -0.43 1.59e-29 Intelligence (multi-trait analysis); BRCA cis rs17401966 0.931 rs11121545 chr1:10411211 A/G cg03954927 chr1:10346856 KIF1B 0.48 14.99 0.51 9.58e-44 Hepatocellular carcinoma; BRCA cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg15017067 chr4:17643749 FAM184B 0.32 9.79 0.36 3.37e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg03452623 chr4:187889614 NA 0.28 9.06 0.34 1.63e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg10556349 chr10:835070 NA 0.75 9.92 0.37 1.09e-21 Eosinophil percentage of granulocytes; BRCA cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg13319975 chr6:146136371 FBXO30 0.41 9.27 0.34 2.82e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs4650994 0.525 rs2493860 chr1:178541492 A/G cg05059571 chr16:84539110 KIAA1609 -0.57 -12.7 -0.45 4.24e-33 HDL cholesterol levels;HDL cholesterol; BRCA cis rs10504229 0.683 rs7000349 chr8:58114569 C/A cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA cis rs703842 0.616 rs870392 chr12:58219173 C/A cg00677455 chr12:58241039 CTDSP2 0.76 17.01 0.56 8.05e-54 Multiple sclerosis; BRCA cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg03433033 chr1:76189801 ACADM 0.68 12.54 0.44 2.14e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs877282 0.755 rs11253399 chr10:790030 T/A cg17470449 chr10:769945 NA 0.43 8.09 0.3 3.1e-15 Uric acid levels; BRCA trans rs877282 1.000 rs877282 chr10:771532 G/A cg22713356 chr15:30763199 NA 1.32 26.52 0.72 4.24e-105 Uric acid levels; BRCA cis rs1801251 1.000 rs7592717 chr2:233577038 G/A cg25237894 chr2:233734115 C2orf82 0.38 10.81 0.39 4.08e-25 Coronary artery disease; BRCA cis rs4234798 0.500 rs7661077 chr4:7219889 C/T cg18431297 chr4:7219810 SORCS2 0.36 10.28 0.38 4.64e-23 Insulin-like growth factors; BRCA cis rs919433 0.713 rs10178946 chr2:198463090 G/T cg00792783 chr2:198669748 PLCL1 0.36 8.14 0.31 2.12e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7077164 1.000 rs1227775 chr10:71580862 C/G cg07630274 chr10:71583235 COL13A1 -0.24 -7.92 -0.3 1.05e-14 Non-alcoholic fatty liver disease histology (lobular); BRCA cis rs9467773 0.596 rs2494693 chr6:26619226 T/C cg11502198 chr6:26597334 ABT1 0.57 12.09 0.43 1.82e-30 Intelligence (multi-trait analysis); BRCA cis rs13315871 0.929 rs13322156 chr3:58287620 C/T cg20936604 chr3:58311152 NA -0.66 -8.46 -0.32 1.83e-16 Cholesterol, total; BRCA cis rs6558530 0.692 rs10105317 chr8:1701432 G/A cg19131313 chr8:1704013 NA -0.4 -8.08 -0.3 3.29e-15 Systolic blood pressure; BRCA cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.81 0.45 1.35e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg09184832 chr6:79620586 NA -0.52 -11.42 -0.41 1.3e-27 Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.14 0.34 7.92e-19 Platelet count; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.56 8.82 0.33 1.05e-17 Renal function-related traits (BUN); BRCA cis rs8014204 0.604 rs2159906 chr14:75390912 G/T cg06637938 chr14:75390232 RPS6KL1 0.78 16.34 0.54 2.13e-50 Caffeine consumption; BRCA cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg02297831 chr4:17616191 MED28 0.38 8.77 0.33 1.56e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11785400 0.793 rs3735993 chr8:143741170 G/A cg24634471 chr8:143751801 JRK 0.43 9.06 0.34 1.61e-18 Schizophrenia; BRCA cis rs3857536 0.740 rs7756519 chr6:66892275 A/G cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs12586317 0.547 rs4982234 chr14:35460106 T/A cg16230307 chr14:35515116 FAM177A1 0.73 15.25 0.52 5.11e-45 Psoriasis; BRCA cis rs7267979 1.000 rs6050617 chr20:25421648 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg18479299 chr3:125709523 NA -0.56 -8.85 -0.33 8.54e-18 Blood pressure (smoking interaction); BRCA cis rs2066819 1.000 rs59295315 chr12:56708576 G/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg13385521 chr17:29058706 SUZ12P 0.76 10.35 0.38 2.52e-23 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs4714291 0.963 rs2475496 chr6:39963850 A/G cg02267698 chr19:7991119 CTXN1 0.42 8.37 0.31 3.72e-16 Strep throat; BRCA cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg00864171 chr11:67383662 NA 0.4 8.34 0.31 4.72e-16 Mean corpuscular volume; BRCA cis rs79839061 0.610 rs12651368 chr4:856787 G/A cg07828340 chr4:882639 GAK 1.03 12.28 0.44 2.82e-31 Intelligence (multi-trait analysis); BRCA cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14442939 chr10:27389572 ANKRD26 0.66 10.98 0.4 8.32e-26 Breast cancer; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg24060327 chr5:131705240 SLC22A5 0.45 9.34 0.35 1.55e-19 Acylcarnitine levels; BRCA cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.95 21.01 0.64 6.82e-75 Smoking behavior; BRCA trans rs3749237 0.964 rs11717463 chr3:49808981 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.32 7.87 0.3 1.55e-14 Resting heart rate; BRCA cis rs34734847 1.000 rs10431385 chr12:121128882 T/C cg21892295 chr12:121157589 UNC119B -0.4 -12.28 -0.44 2.78e-31 Mean corpuscular volume; BRCA cis rs6580649 0.824 rs1635534 chr12:48386553 A/G cg05342945 chr12:48394962 COL2A1 -0.48 -9.53 -0.35 3.12e-20 Lung cancer; BRCA cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg18446336 chr7:2847575 GNA12 -0.35 -8.31 -0.31 5.71e-16 Height; BRCA cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg27129171 chr3:47204927 SETD2 -0.71 -16.96 -0.56 1.46e-53 Colorectal cancer; BRCA cis rs2732480 0.538 rs1387259 chr12:48703522 C/T cg04545296 chr12:48745243 ZNF641 -0.24 -7.96 -0.3 7.9e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs637571 0.522 rs7105628 chr11:65763067 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.39 9.03 0.34 1.97e-18 Eosinophil percentage of white cells; BRCA cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg18761221 chr20:60518478 NA -0.34 -8.49 -0.32 1.4e-16 Obesity-related traits; BRCA trans rs7618501 1.000 rs3749241 chr3:49744392 A/G cg21659725 chr3:3221576 CRBN -0.71 -21.49 -0.65 1.55e-77 Intelligence (multi-trait analysis); BRCA cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.57 11.98 0.43 5.5e-30 Monocyte percentage of white cells; BRCA cis rs7833790 0.963 rs2400473 chr8:82703403 C/T cg27398817 chr8:82754497 SNX16 -0.45 -8.6 -0.32 6.32e-17 Diastolic blood pressure; BRCA cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg19904058 chr10:135279010 LOC619207 -0.4 -9.41 -0.35 9.14e-20 Systemic lupus erythematosus; BRCA cis rs11098499 0.754 rs1511025 chr4:120240238 T/C cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA cis rs9388451 0.874 rs9398787 chr6:126090608 A/G cg05901451 chr6:126070800 HEY2 -0.7 -20.07 -0.62 7.64e-70 Brugada syndrome; BRCA cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg10811474 chr19:8428787 ANGPTL4 -0.33 -8.35 -0.31 4.15e-16 HDL cholesterol; BRCA cis rs877529 0.967 rs139414 chr22:39553819 G/A cg18708252 chr22:39545030 CBX7 -0.32 -8.42 -0.32 2.42e-16 Multiple myeloma; BRCA cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg17420585 chr12:42539391 GXYLT1 0.48 10.38 0.38 1.94e-23 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg10729496 chr3:10149963 C3orf24 0.48 9.15 0.34 7.7e-19 Alzheimer's disease; BRCA cis rs2032447 0.714 rs199736 chr6:25936787 C/T cg12310025 chr6:25882481 NA -0.5 -11.47 -0.41 7.69e-28 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.722 rs1814814 chr4:120258124 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 8.29 0.31 6.5e-16 Corneal astigmatism; BRCA cis rs1691799 0.867 rs961049 chr12:66762591 A/C cg16791601 chr12:66731901 HELB 0.57 14.22 0.49 4.63e-40 White blood cell count (basophil); BRCA cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg20203395 chr5:56204925 C5orf35 -0.5 -10.11 -0.37 2.13e-22 Initial pursuit acceleration; BRCA cis rs1691799 0.899 rs1168314 chr12:66746937 A/G cg16791601 chr12:66731901 HELB -0.69 -19.69 -0.61 8.5e-68 White blood cell count (basophil); BRCA cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.42 0.32 2.56e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg08219700 chr8:58056026 NA -0.59 -9.64 -0.36 1.32e-20 Developmental language disorder (linguistic errors); BRCA cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg10169327 chr19:45448959 APOC2 0.31 7.81 0.3 2.31e-14 Blood protein levels; BRCA cis rs6582630 0.638 rs12424222 chr12:38548273 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.23 -0.38 7.61e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg27588902 chr6:42928151 GNMT 0.32 10.56 0.39 3.82e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg21138405 chr5:131827807 IRF1 -0.4 -13.33 -0.47 6.37e-36 Asthma (sex interaction); BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg16606324 chr3:10149918 C3orf24 0.53 10.56 0.39 3.77e-24 Alzheimer's disease; BRCA cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg16405210 chr4:1374714 KIAA1530 -0.47 -10.97 -0.4 8.6e-26 Longevity; BRCA cis rs813218 0.647 rs6788750 chr3:99774720 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 8.8 0.33 1.25e-17 Orofacial clefts; BRCA cis rs10782582 0.609 rs11584577 chr1:76242378 A/G cg03433033 chr1:76189801 ACADM -0.4 -8.14 -0.31 2.02e-15 Daytime sleep phenotypes; BRCA cis rs7044106 0.791 rs12554440 chr9:123485333 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 15.23 0.52 6.26e-45 Hip circumference adjusted for BMI; BRCA cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg04315214 chr1:2043799 PRKCZ -0.44 -12.02 -0.43 3.61e-30 Height; BRCA cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg00012203 chr2:219082015 ARPC2 -0.48 -9.18 -0.34 5.88e-19 Colorectal cancer; BRCA cis rs4975709 0.589 rs4975746 chr5:1861069 G/A cg20790798 chr5:1857306 NA -0.38 -9.1 -0.34 1.13e-18 Cardiovascular disease risk factors; BRCA cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs875971 0.964 rs1643388 chr7:65844562 T/C cg11764359 chr7:65958608 NA 0.81 19.67 0.61 1.05e-67 Aortic root size; BRCA cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg11890956 chr21:40555474 PSMG1 -0.81 -19.3 -0.61 9.88e-66 Cognitive function; BRCA cis rs17270561 0.609 rs9393665 chr6:25744284 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs12497850 0.829 rs8926 chr3:49052785 T/A cg06212747 chr3:49208901 KLHDC8B 0.48 9.85 0.36 2.06e-21 Parkinson's disease; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg12564285 chr5:131593104 PDLIM4 0.43 11.04 0.4 4.77e-26 Acylcarnitine levels; BRCA cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 11.63 0.42 1.63e-28 Personality dimensions; BRCA trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg03929089 chr4:120376271 NA 0.49 8.3 0.31 6.27e-16 Axial length; BRCA cis rs796364 0.806 rs112486506 chr2:201073947 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.59 -8.62 -0.32 5.4e-17 Schizophrenia; BRCA cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg18876405 chr7:65276391 NA -0.69 -17.94 -0.58 1.43e-58 Aortic root size; BRCA cis rs4363385 0.747 rs6670614 chr1:152964338 A/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.84 -0.33 9.32e-18 Inflammatory skin disease; BRCA cis rs9611519 0.558 rs8137906 chr22:41442566 A/G cg03806693 chr22:41940476 POLR3H -0.41 -7.81 -0.3 2.29e-14 Neuroticism; BRCA trans rs61931739 0.534 rs11052960 chr12:33997754 A/T cg26384229 chr12:38710491 ALG10B 0.66 13.84 0.48 2.82e-38 Morning vs. evening chronotype; BRCA cis rs7593730 0.636 rs10170600 chr2:161118687 T/C cg22609984 chr2:161126801 NA 0.43 9.24 0.34 3.53e-19 Type 2 diabetes; BRCA cis rs12220238 1.000 rs8255 chr10:75879750 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.49 8.06 0.3 3.65e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs16958440 0.867 rs16949275 chr18:44700703 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.47 0.47 1.43e-36 Sitting height ratio; BRCA cis rs2882667 0.728 rs7722413 chr5:138278251 T/C cg04439458 chr5:138467593 SIL1 -0.32 -8.2 -0.31 1.27e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs8062405 0.723 rs35175818 chr16:28608746 A/C cg16576597 chr16:28551801 NUPR1 0.34 9.0 0.34 2.65e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg12923728 chr3:195709715 SDHAP1 -0.53 -9.17 -0.34 6.47e-19 Pancreatic cancer; BRCA cis rs11190604 1.000 rs3750719 chr10:102248950 C/G cg07080220 chr10:102295463 HIF1AN 0.58 12.05 0.43 2.7e-30 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6005807 0.563 rs9620811 chr22:29058409 T/C cg12565055 chr22:29076175 TTC28 0.5 9.47 0.35 5.27e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg24642844 chr7:1081250 C7orf50 -0.58 -11.94 -0.43 8.12e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2991971 1.000 rs2991971 chr1:46012748 C/G cg24296786 chr1:45957014 TESK2 0.62 15.39 0.52 1.08e-45 High light scatter reticulocyte count; BRCA cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg22535103 chr8:58192502 C8orf71 -0.6 -13.08 -0.46 8.35e-35 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg05863683 chr7:1912471 MAD1L1 -0.35 -8.18 -0.31 1.55e-15 Bipolar disorder and schizophrenia; BRCA cis rs2832191 0.740 rs13048618 chr21:30458684 A/G cg24692254 chr21:30365293 RNF160 0.78 21.63 0.65 2.7e-78 Dental caries; BRCA trans rs2204008 0.720 rs11170774 chr12:38021722 C/T cg06521331 chr12:34319734 NA 0.45 8.82 0.33 1.06e-17 Bladder cancer; BRCA cis rs2625529 0.689 rs4526973 chr15:72138719 A/G cg16672083 chr15:72433130 SENP8 -0.65 -15.54 -0.52 1.95e-46 Red blood cell count; BRCA cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.89e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg00031303 chr3:195681400 NA 0.49 8.94 0.33 4.18e-18 Pancreatic cancer; BRCA cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 12.32 0.44 1.93e-31 Calcium levels; BRCA cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 9.31 0.35 1.96e-19 Personality dimensions; BRCA cis rs1008375 0.966 rs6449325 chr4:17699509 C/T cg16339924 chr4:17578868 LAP3 -0.46 -10.22 -0.37 7.95e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs3942852 0.910 rs10742829 chr11:48115837 C/T cg15704280 chr7:45808275 SEPT13 0.48 8.44 0.32 2.15e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs2070997 0.667 rs12156431 chr9:133719540 A/G cg11464064 chr9:133710261 ABL1 0.51 9.3 0.35 2.18e-19 Response to amphetamines; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg03188948 chr7:1209495 NA 0.63 12.99 0.46 2.06e-34 Longevity;Endometriosis; BRCA cis rs2282802 0.685 rs2053055 chr5:139646776 C/T cg26211634 chr5:139558579 C5orf32 0.35 8.38 0.31 3.5e-16 Intelligence (multi-trait analysis); BRCA cis rs589448 0.967 rs634512 chr12:69754012 C/T cg20891283 chr12:69753455 YEATS4 0.84 28.41 0.75 1.93e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg04025307 chr7:1156635 C7orf50 0.55 11.49 0.41 6.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7085104 0.514 rs284855 chr10:104574422 A/G cg04362960 chr10:104952993 NT5C2 -0.34 -8.09 -0.3 3.02e-15 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs1005277 0.638 rs1005278 chr10:38218748 G/A cg25427524 chr10:38739819 LOC399744 0.59 12.56 0.44 1.74e-32 Extrinsic epigenetic age acceleration; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg21143896 chr7:2802374 GNA12 -0.35 -8.9 -0.33 5.81e-18 Height; BRCA cis rs858239 0.600 rs1115941 chr7:23137188 C/T cg23682824 chr7:23144976 KLHL7 0.46 12.26 0.44 3.34e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs2230307 0.572 rs2810419 chr1:100643968 C/A cg24955406 chr1:100503596 HIAT1 -0.45 -8.45 -0.32 1.91e-16 Carotid intima media thickness; BRCA trans rs9291683 0.597 rs11722989 chr4:10126139 A/G cg26043149 chr18:55253948 FECH -0.39 -8.73 -0.33 2.17e-17 Bone mineral density; BRCA cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg22800045 chr5:56110881 MAP3K1 -0.47 -9.35 -0.35 1.47e-19 Initial pursuit acceleration; BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03352830 chr11:487213 PTDSS2 0.87 13.62 0.47 2.74e-37 Body mass index; BRCA trans rs800082 0.690 rs2575191 chr3:144279228 G/A cg24215973 chr2:240111563 HDAC4 0.41 10.67 0.39 1.44e-24 Smoking behavior; BRCA cis rs1371614 0.501 rs4992933 chr2:27178972 C/A cg00617064 chr2:27272375 NA -0.31 -8.06 -0.3 3.67e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.89 0.33 5.97e-18 Tonsillectomy; BRCA trans rs6598955 0.671 rs17163868 chr1:26648381 A/G cg07461501 chr17:79650226 HGS;ARL16 0.59 14.51 0.5 1.9e-41 Obesity-related traits; BRCA cis rs13102973 0.931 rs13128765 chr4:135888141 A/G cg14419869 chr4:135874104 NA 0.53 11.15 0.4 1.69e-26 Subjective well-being; BRCA cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg13256891 chr4:100009986 ADH5 0.49 9.61 0.36 1.6e-20 Alcohol dependence; BRCA cis rs7829975 0.572 rs7005000 chr8:8796602 A/G cg08975724 chr8:8085496 FLJ10661 -0.41 -8.83 -0.33 9.69e-18 Mood instability; BRCA cis rs1707322 1.000 rs785468 chr1:46521517 G/A cg06784218 chr1:46089804 CCDC17 -0.45 -10.79 -0.39 4.67e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2576037 0.566 rs2437854 chr18:44557613 T/C cg19077165 chr18:44547161 KATNAL2 0.64 14.43 0.5 4.44e-41 Personality dimensions; BRCA cis rs2282802 0.651 rs13353827 chr5:139654537 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.35 0.31 4.13e-16 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 9.27 0.34 2.9e-19 Renal function-related traits (BUN); BRCA cis rs9790314 0.601 rs1450519 chr3:161094930 A/G cg04691961 chr3:161091175 C3orf57 -0.4 -9.34 -0.35 1.52e-19 Morning vs. evening chronotype; BRCA trans rs10506458 0.915 rs17763441 chr12:63418335 T/C cg22491629 chr6:157744540 C6orf35 -0.62 -11.75 -0.42 5.16e-29 Hemostatic factors and hematological phenotypes; BRCA cis rs6484504 0.600 rs942272 chr11:31364368 C/T cg06552810 chr11:31128660 NA 0.4 8.73 0.33 2.16e-17 Red blood cell count; BRCA cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg18490616 chr2:88469792 THNSL2 -0.48 -9.36 -0.35 1.38e-19 Response to metformin (IC50); BRCA cis rs312273 0.582 rs312277 chr12:41256755 A/C cg17827154 chr12:41323612 CNTN1 -0.34 -7.92 -0.3 1.07e-14 Bipolar disorder; BRCA cis rs586533 0.881 rs10893644 chr11:99512157 G/C cg22878054 chr11:99397252 CNTN5 0.31 7.89 0.3 1.27e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs1298908 0.639 rs2236568 chr10:82035923 C/A cg01528321 chr10:82214614 TSPAN14 0.48 10.27 0.38 5.11e-23 Diabetic kidney disease; BRCA cis rs1448094 0.621 rs10863090 chr12:86282211 C/T cg19622623 chr12:86230825 RASSF9 -0.29 -8.26 -0.31 8.66e-16 Major depressive disorder; BRCA cis rs11955398 0.625 rs6449485 chr5:59995441 C/T cg02684056 chr5:59996105 DEPDC1B 0.39 9.11 0.34 1.08e-18 Intelligence (multi-trait analysis); BRCA cis rs11711311 1.000 rs9811746 chr3:113515060 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.37 9.59 0.35 1.87e-20 IgG glycosylation; BRCA cis rs9393777 0.557 rs7759741 chr6:27241043 C/T cg12292205 chr6:26970375 C6orf41 -0.66 -10.99 -0.4 7.63e-26 Intelligence (multi-trait analysis); BRCA trans rs1200821 0.552 rs12253170 chr10:37601063 A/G cg25427524 chr10:38739819 LOC399744 -0.36 -7.98 -0.3 6.84e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs67072384 1.000 rs7120605 chr11:72444615 A/G cg04827223 chr11:72435913 ARAP1 -0.69 -11.3 -0.41 3.91e-27 Alloimmunization response to red blood cell transfusion in sickle cell anemia; BRCA cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg06552810 chr11:31128660 NA -0.39 -8.54 -0.32 9.9900000000000006e-17 Red blood cell count; BRCA cis rs6942756 0.876 rs7789697 chr7:129060386 T/A cg02491457 chr7:128862824 NA -0.57 -11.81 -0.42 3.01e-29 White matter hyperintensity burden; BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -9.42 -0.35 7.97e-20 Total body bone mineral density; BRCA cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg27478167 chr7:817139 HEATR2 -0.42 -8.97 -0.33 3.29e-18 Cerebrospinal P-tau181p levels; BRCA cis rs8114671 0.869 rs2145559 chr20:33651725 G/A cg24642439 chr20:33292090 TP53INP2 -0.43 -8.51 -0.32 1.23e-16 Height; BRCA cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg17366294 chr4:99064904 C4orf37 0.55 11.51 0.41 5.33e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs921968 0.541 rs549026 chr2:219339283 T/C cg10223061 chr2:219282414 VIL1 -0.27 -7.9 -0.3 1.25e-14 Mean corpuscular hemoglobin concentration; BRCA trans rs10411161 0.702 rs8110531 chr19:52383510 C/T cg22319618 chr22:45562946 NUP50 -0.41 -7.84 -0.3 1.84e-14 Breast cancer; BRCA cis rs3824344 0.531 rs7870336 chr9:37007769 C/G cg14294708 chr9:37120828 ZCCHC7 -0.43 -8.7 -0.33 2.87e-17 Intelligence; BRCA cis rs9287719 0.674 rs759399 chr2:10796883 T/C cg00105475 chr2:10696890 NA -0.38 -8.83 -0.33 9.85e-18 Prostate cancer; BRCA cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.5 -0.44 2.98e-32 Bipolar disorder; BRCA cis rs4363385 0.818 rs11205176 chr1:153002481 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -8.81 -0.33 1.19e-17 Inflammatory skin disease; BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg02951883 chr7:2050386 MAD1L1 -0.36 -8.13 -0.31 2.17e-15 Bipolar disorder and schizophrenia; BRCA cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.43 8.28 0.31 7.22e-16 Lung cancer in ever smokers; BRCA cis rs9462027 0.628 rs10947531 chr6:34765118 A/C cg07306190 chr6:34760872 UHRF1BP1 0.26 8.01 0.3 5.37e-15 Systemic lupus erythematosus; BRCA cis rs1448094 0.621 rs10863089 chr12:86279699 C/T cg19622623 chr12:86230825 RASSF9 -0.28 -8.12 -0.31 2.41e-15 Major depressive disorder; BRCA cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24308560 chr3:49941425 MST1R -0.39 -8.47 -0.32 1.64e-16 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs3846055 chr3:134203973 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.5 -0.61 8.85e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs7829975 0.626 rs907183 chr8:8729761 C/G cg21775007 chr8:11205619 TDH -0.38 -7.89 -0.3 1.36e-14 Mood instability; BRCA cis rs10504073 0.506 rs7007271 chr8:49941897 T/C cg00325661 chr8:49890786 NA 0.45 13.06 0.46 1.06e-34 Blood metabolite ratios; BRCA cis rs11245387 0.633 rs2086945 chr10:126543993 C/T cg08799069 chr10:126477246 METTL10 0.37 8.28 0.31 7.2e-16 Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1); BRCA cis rs7582180 0.629 rs12621892 chr2:100947124 G/C cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA cis rs9325144 0.647 rs11168741 chr12:38989120 C/T cg26384229 chr12:38710491 ALG10B -0.48 -11.38 -0.41 1.81e-27 Morning vs. evening chronotype; BRCA cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg11266682 chr4:10021025 SLC2A9 0.47 12.07 0.43 2.38e-30 Bone mineral density; BRCA cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg24060327 chr5:131705240 SLC22A5 0.61 11.5 0.41 6.04e-28 Breast cancer; BRCA cis rs829883 0.934 rs249814 chr12:98892964 A/G cg25150519 chr12:98850993 NA 0.59 11.94 0.43 7.95e-30 Colorectal adenoma (advanced); BRCA trans rs3774749 0.565 rs2188151 chr3:50201924 A/C cg21659725 chr3:3221576 CRBN -0.36 -8.45 -0.32 1.94e-16 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg03146154 chr1:46216737 IPP 0.5 11.01 0.4 6.46e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.64 10.81 0.39 4.03e-25 Renal function-related traits (BUN); BRCA cis rs4285028 0.747 rs9824235 chr3:121432177 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -13.99 -0.48 5.22e-39 Multiple sclerosis; BRCA cis rs7552404 0.960 rs12085123 chr1:76149749 G/A cg22875332 chr1:76189707 ACADM 0.7 15.05 0.51 5.04e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2762353 0.935 rs1165209 chr6:25801319 G/A cg03517284 chr6:25882590 NA -0.47 -10.52 -0.38 5.74e-24 Blood metabolite levels; BRCA cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg17892150 chr10:133769511 PPP2R2D -0.72 -15.44 -0.52 5.81e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7267979 1.000 rs6050573 chr20:25366065 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.36 0.35 1.34e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg00321850 chr1:175162397 KIAA0040 -0.41 -11.37 -0.41 2.14e-27 Alcohol dependence; BRCA cis rs6942756 1.000 rs6467243 chr7:129001508 A/G cg02491457 chr7:128862824 NA -0.64 -12.57 -0.45 1.53e-32 White matter hyperintensity burden; BRCA cis rs9880211 0.948 rs9857966 chr3:136279390 A/G cg21827317 chr3:136751795 NA -0.45 -8.22 -0.31 1.1e-15 Body mass index;Height; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg15112475 chr7:1198522 ZFAND2A -0.4 -8.78 -0.33 1.49e-17 Longevity;Endometriosis; BRCA cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg06212747 chr3:49208901 KLHDC8B 0.48 9.78 0.36 3.68e-21 Parkinson's disease; BRCA cis rs1468333 0.824 rs28704868 chr5:137590786 G/A cg27119451 chr5:137514611 BRD8;KIF20A 0.4 7.81 0.3 2.28e-14 Resting heart rate; BRCA cis rs4566357 0.521 rs78411533 chr2:227910807 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.48 -0.35 4.75e-20 Coronary artery disease; BRCA cis rs11190604 1.000 rs11190556 chr10:102209223 G/A cg07080220 chr10:102295463 HIF1AN 0.49 11.33 0.41 2.98e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.11 0.4 2.47e-26 Platelet count; BRCA cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.68 15.93 0.53 2.4e-48 Systemic lupus erythematosus; BRCA cis rs7246967 0.551 rs8102812 chr19:22879243 A/T cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg13073564 chr4:8508604 NA -0.37 -9.41 -0.35 8.57e-20 Response to antineoplastic agents; BRCA cis rs7247513 0.797 rs3815914 chr19:12760664 T/C cg01871581 chr19:12707946 ZNF490 -0.62 -13.16 -0.46 3.53e-35 Bipolar disorder; BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg04166393 chr7:2884313 GNA12 0.49 9.56 0.35 2.54e-20 Height; BRCA cis rs12477438 0.871 rs62156364 chr2:99695097 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.68 -14.12 -0.49 1.38e-39 Chronic sinus infection; BRCA cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg18225595 chr11:63971243 STIP1 0.56 13.6 0.47 3.45e-37 Platelet count; BRCA cis rs9309711 0.736 rs13409102 chr2:3496321 G/A cg16153549 chr2:3496821 NA -0.46 -10.46 -0.38 9.24e-24 Neurofibrillary tangles; BRCA cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg17211192 chr8:82754475 SNX16 -0.62 -11.88 -0.43 1.46e-29 Diastolic blood pressure; BRCA cis rs10752881 1.000 rs4233193 chr1:182970865 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.5 0.55 3.31e-51 Colorectal cancer; BRCA cis rs514406 0.505 rs436363 chr1:53172163 T/C cg08859206 chr1:53392774 SCP2 -0.41 -8.76 -0.33 1.76e-17 Monocyte count; BRCA cis rs6811802 1 rs6811802 chr4:78932838 G/C cg07207937 chr4:78783799 MRPL1 -0.65 -12.22 -0.44 5.23e-31 Left ventricular obstructive tract defect (inherited effect); BRCA cis rs17095355 1.000 rs12570230 chr10:111691614 T/C cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.14 -0.37 1.71e-22 Biliary atresia; BRCA cis rs56399783 0.901 rs17132741 chr7:2868997 C/T cg19731401 chr7:2775893 GNA12 -0.48 -8.91 -0.33 5.16e-18 Childhood ear infection; BRCA cis rs13136331 0.879 rs2126650 chr4:88710587 C/T cg22416721 chr4:88570574 DMP1 0.46 10.04 0.37 4.05e-22 Sitting height ratio; BRCA cis rs1018836 0.847 rs35409073 chr8:91648036 G/T cg16814680 chr8:91681699 NA -0.61 -12.82 -0.45 1.2e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs2346177 0.580 rs7565770 chr2:46683683 A/C cg26688816 chr2:46740690 ATP6V1E2 -0.41 -9.14 -0.34 8.39e-19 HDL cholesterol; BRCA cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -9.81 -0.36 3.01e-21 Developmental language disorder (linguistic errors); BRCA cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg02038168 chr22:39784481 NA -0.43 -8.99 -0.34 2.71e-18 Intelligence (multi-trait analysis); BRCA cis rs950169 0.579 rs12912716 chr15:84664263 A/T cg12863693 chr15:85201151 NMB 0.45 8.04 0.3 4.48e-15 Schizophrenia; BRCA cis rs36051895 0.553 rs12338854 chr9:5057568 G/C cg02405213 chr9:5042618 JAK2 -0.49 -9.52 -0.35 3.56e-20 Pediatric autoimmune diseases; BRCA cis rs250677 0.652 rs250680 chr5:148436024 T/C cg23229984 chr5:148520753 ABLIM3 0.35 8.79 0.33 1.39e-17 Breast cancer; BRCA cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.47 -10.69 -0.39 1.23e-24 Chronic sinus infection; BRCA cis rs17767294 0.708 rs72845897 chr6:27699357 T/C cg08851530 chr6:28072375 NA 1.11 10.08 0.37 2.81e-22 Parkinson's disease; BRCA cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg14440974 chr22:39074834 NA -0.37 -8.43 -0.32 2.24e-16 Menopause (age at onset); BRCA cis rs7903847 0.619 rs76094900 chr10:99158164 G/A cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs13046373 0.535 rs1605428 chr21:32028976 T/C cg16431978 chr21:31797932 KRTAP13-3 0.36 8.76 0.33 1.74e-17 HDL cholesterol; BRCA trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg00717180 chr2:96193071 NA 0.31 8.67 0.32 3.68e-17 Coronary artery disease; BRCA cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg23796481 chr11:64053134 BAD;GPR137 0.5 10.16 0.37 1.44e-22 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg05868516 chr6:26286170 HIST1H4H 0.41 8.1 0.31 2.8e-15 Educational attainment; BRCA cis rs727479 0.502 rs7180552 chr15:51506768 T/G cg19946085 chr15:51559439 CYP19A1 -0.3 -8.48 -0.32 1.51e-16 Estradiol levels; BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg22903471 chr2:27725779 GCKR -0.37 -9.03 -0.34 2.02e-18 Total body bone mineral density; BRCA cis rs10924970 0.967 rs4481838 chr1:235442626 A/G cg26050004 chr1:235667680 B3GALNT2 0.35 8.69 0.33 3.01e-17 Asthma; BRCA cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -8.46 -0.32 1.78e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs73242632 1.000 rs73242618 chr4:57809549 A/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.65 7.93 0.3 9.85e-15 Congenital heart disease (maternal effect); BRCA cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg04727924 chr7:799746 HEATR2 -0.53 -9.93 -0.37 1.02e-21 Cerebrospinal P-tau181p levels; BRCA cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.67 0.39 1.41e-24 Bipolar disorder; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg13047869 chr3:10149882 C3orf24 0.59 12.13 0.43 1.26e-30 Alzheimer's disease; BRCA cis rs7809950 0.637 rs3801964 chr7:106836242 T/C cg23024343 chr7:107201750 COG5 -0.45 -9.03 -0.34 2.03e-18 Coronary artery disease; BRCA trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs3824867 0.920 rs10742805 chr11:47454701 A/G cg20307385 chr11:47447363 PSMC3 0.51 11.5 0.41 5.87e-28 Mean corpuscular hemoglobin; BRCA cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg17507749 chr15:85114479 UBE2QP1 0.56 10.59 0.39 3.04e-24 Schizophrenia; BRCA cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs5751614 1.000 rs2267018 chr22:23588193 C/T cg25410636 chr22:23605411 BCR -0.41 -10.33 -0.38 3.19e-23 Height; BRCA cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs6582630 0.519 rs9738104 chr12:38338459 A/C cg06521331 chr12:34319734 NA -0.51 -9.17 -0.34 6.67e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg11833968 chr6:79620685 NA -0.43 -9.72 -0.36 6.42e-21 Intelligence (multi-trait analysis); BRCA cis rs7737355 0.947 rs3776007 chr5:130875085 C/G cg06307176 chr5:131281290 NA -0.53 -10.59 -0.39 2.87e-24 Life satisfaction; BRCA trans rs3857536 0.813 rs9354405 chr6:66948575 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.14 -0.31 2.06e-15 Blood trace element (Cu levels); BRCA cis rs7178424 0.905 rs8027751 chr15:62247720 A/T cg00456672 chr15:62358751 C2CD4A 0.43 9.89 0.36 1.51e-21 Height; BRCA cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg10932868 chr11:921992 NA 0.48 12.3 0.44 2.45e-31 Alzheimer's disease (late onset); BRCA cis rs13102973 0.797 rs4453983 chr4:135905424 A/C cg14419869 chr4:135874104 NA 0.45 9.02 0.34 2.26e-18 Subjective well-being; BRCA cis rs1691799 0.899 rs1168329 chr12:66731864 C/A cg16791601 chr12:66731901 HELB -0.7 -19.95 -0.62 3.14e-69 White blood cell count (basophil); BRCA cis rs9814567 0.806 rs11927539 chr3:134319448 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs826838 0.967 rs826858 chr12:39116731 A/G cg13010199 chr12:38710504 ALG10B -0.43 -10.06 -0.37 3.32e-22 Heart rate; BRCA cis rs2046867 0.862 rs67961837 chr3:72840877 T/G cg25664220 chr3:72788482 NA -0.55 -11.54 -0.42 4.23e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs727479 0.502 rs12591172 chr15:51503727 G/A cg19946085 chr15:51559439 CYP19A1 -0.3 -8.63 -0.32 5.03e-17 Estradiol levels; BRCA cis rs11608355 0.515 rs11609921 chr12:109918405 A/G cg05360138 chr12:110035743 NA 0.74 13.58 0.47 4.43e-37 Neuroticism; BRCA cis rs7666738 0.830 rs7659593 chr4:98934823 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg04025307 chr7:1156635 C7orf50 0.48 11.88 0.43 1.43e-29 Longevity;Endometriosis; BRCA cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg06484146 chr7:12443880 VWDE -0.7 -9.77 -0.36 4.17e-21 Coronary artery disease; BRCA cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg12573674 chr2:1569213 NA -0.44 -8.51 -0.32 1.24e-16 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7178424 0.742 rs963024 chr15:62211450 G/A cg00456672 chr15:62358751 C2CD4A 0.39 9.33 0.35 1.68e-19 Height; BRCA cis rs7729447 0.813 rs1031648 chr5:32692105 T/A cg16267343 chr5:32710456 NPR3 0.42 8.5 0.32 1.31e-16 Blood pressure; BRCA cis rs4409675 0.597 rs1000431 chr1:28225114 C/T cg23691781 chr1:28212827 C1orf38 0.32 10.61 0.39 2.42e-24 Corneal astigmatism; BRCA cis rs933688 1.000 rs2052553 chr5:90729906 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 21.85 0.65 1.87e-79 Smoking behavior; BRCA cis rs9807989 0.507 rs2160201 chr2:103033961 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma; BRCA cis rs9814567 0.929 rs13316205 chr3:134223563 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.01 -0.34 2.27e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg06618935 chr21:46677482 NA -0.36 -8.01 -0.3 5.55e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs3733585 0.783 rs13148371 chr4:10032561 C/T cg26043149 chr18:55253948 FECH 0.42 8.98 0.33 3.07e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2625529 0.816 rs4777467 chr15:72138478 T/C cg16672083 chr15:72433130 SENP8 -0.8 -16.45 -0.55 5.82e-51 Red blood cell count; BRCA cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg24812749 chr6:127587940 RNF146 0.87 20.07 0.62 7.99e-70 Breast cancer; BRCA cis rs9790314 0.747 rs4616689 chr3:160856269 A/G cg03342759 chr3:160939853 NMD3 -0.55 -10.74 -0.39 7.35e-25 Morning vs. evening chronotype; BRCA cis rs7336332 0.569 rs7988412 chr13:28000282 C/T cg01674679 chr13:27998804 GTF3A -0.44 -8.58 -0.32 7.02e-17 Weight; BRCA trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.3 -8.08 -0.3 3.13e-15 Intelligence (multi-trait analysis); BRCA cis rs7246967 0.673 rs28649847 chr19:22811540 G/T cg23217946 chr19:22817039 ZNF492 0.47 8.43 0.32 2.22e-16 Bronchopulmonary dysplasia; BRCA cis rs9811920 0.603 rs2638948 chr3:99501539 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.53 -12.6 -0.45 1.09e-32 Axial length; BRCA cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg05347473 chr6:146136440 FBXO30 0.55 10.61 0.39 2.39e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs6835098 1.000 rs9990666 chr4:174083150 G/T cg08422745 chr4:174089978 GALNT7 -0.8 -18.39 -0.59 6.24e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7833986 0.501 rs2719226 chr8:57044066 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.93 0.46 3.79e-34 Height; BRCA cis rs7552167 0.789 rs6424162 chr1:24512576 T/C cg01960748 chr1:24522592 NA -0.62 -10.08 -0.37 2.78e-22 Psoriasis vulgaris; BRCA trans rs61931739 0.517 rs7960878 chr12:34055645 C/A cg26384229 chr12:38710491 ALG10B 0.68 14.37 0.49 9.31e-41 Morning vs. evening chronotype; BRCA cis rs2625529 0.668 rs12591338 chr15:72556847 T/A cg16672083 chr15:72433130 SENP8 -0.81 -16.99 -0.56 1.09e-53 Red blood cell count; BRCA cis rs4906332 1.000 rs3783398 chr14:103949378 C/T cg19000871 chr14:103996768 TRMT61A 0.35 8.04 0.3 4.42e-15 Coronary artery disease; BRCA cis rs6866344 0.697 rs11739893 chr5:178127837 G/A cg10224037 chr5:178157518 ZNF354A 0.76 15.88 0.53 4.15e-48 Neutrophil percentage of white cells; BRCA cis rs3812049 0.784 rs6889311 chr5:127431285 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.59 10.78 0.39 5.18e-25 Lymphocyte counts;Red cell distribution width; BRCA cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.48 9.29 0.35 2.35e-19 Lung cancer in ever smokers; BRCA cis rs68170813 0.559 rs17429118 chr7:106964052 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.43 -0.32 2.33e-16 Coronary artery disease; BRCA trans rs11146838 1 rs11146838 chr10:39149977 A/T cg17830980 chr10:43048298 ZNF37B -0.48 -11.18 -0.4 1.3e-26 Breast cancer; BRCA cis rs13046373 0.535 rs2226377 chr21:32031915 T/C cg14062083 chr21:31802829 KRTAP13-4 0.35 9.17 0.34 6.25e-19 HDL cholesterol; BRCA trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.03e-14 Corneal astigmatism; BRCA cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.25e-16 Bipolar disorder; BRCA trans rs6762477 0.748 rs11717349 chr3:50223977 C/T cg21659725 chr3:3221576 CRBN -0.34 -8.23 -0.31 1.05e-15 Menarche (age at onset); BRCA cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg05623727 chr3:50126028 RBM5 0.51 12.28 0.44 2.91e-31 Body mass index; BRCA cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg08213375 chr14:104286397 PPP1R13B 0.51 11.43 0.41 1.16e-27 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs11249608 0.548 rs7704565 chr5:178473923 G/C cg21905437 chr5:178450457 ZNF879 0.51 10.17 0.37 1.26e-22 Pubertal anthropometrics; BRCA cis rs2742417 0.609 rs2673066 chr3:45771200 C/T cg04837898 chr3:45731254 SACM1L -0.38 -7.86 -0.3 1.61e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15506890 chr2:3487001 NA -0.58 -13.16 -0.46 3.64e-35 Neurofibrillary tangles; BRCA trans rs12517041 1.000 rs10064991 chr5:23318464 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs2882667 0.537 rs6887866 chr5:138437696 T/C cg04439458 chr5:138467593 SIL1 -0.29 -7.85 -0.3 1.81e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg18876405 chr7:65276391 NA -0.62 -15.5 -0.52 3.28e-46 Aortic root size; BRCA cis rs12477438 1.000 rs6732980 chr2:99921613 A/G cg08885076 chr2:99613938 TSGA10 -0.47 -8.99 -0.33 2.88e-18 Chronic sinus infection; BRCA cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.62 0.32 5.23e-17 Glomerular filtration rate (creatinine); BRCA cis rs6684428 1.000 rs12124871 chr1:56372247 C/T cg11651538 chr1:56320950 NA -0.46 -7.81 -0.3 2.32e-14 Airflow obstruction; BRCA cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.01 0.4 6.12e-26 Bipolar disorder; BRCA cis rs7586879 0.551 rs7565460 chr2:25130073 C/T cg01884057 chr2:25150051 NA 0.34 9.12 0.34 9.39e-19 Body mass index; BRCA cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg16325326 chr1:53192061 ZYG11B 0.7 16.96 0.56 1.58e-53 Monocyte count; BRCA cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA cis rs7772486 0.743 rs9403742 chr6:146060193 A/C cg23711669 chr6:146136114 FBXO30 0.7 16.61 0.55 9.15e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg01579765 chr21:45077557 HSF2BP 0.38 10.2 0.37 9.68e-23 Mean corpuscular volume; BRCA cis rs3733585 0.638 rs6449155 chr4:9956547 T/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.93e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.540 rs781152 chr7:65479572 T/A cg18876405 chr7:65276391 NA 0.71 18.24 0.59 3.68e-60 Aortic root size; BRCA cis rs7178424 0.806 rs1425270 chr15:62237710 C/T cg00456672 chr15:62358751 C2CD4A 0.4 9.74 0.36 5.35e-21 Height; BRCA cis rs507080 0.769 rs745663 chr11:118529595 A/G cg08498647 chr11:118550644 TREH -0.37 -8.12 -0.31 2.4e-15 Serum metabolite levels; BRCA cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 12.01 0.43 4.35e-30 Personality dimensions; BRCA cis rs858239 0.899 rs10262243 chr7:23290987 G/A cg23682824 chr7:23144976 KLHL7 0.33 8.25 0.31 8.73e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg26248373 chr2:1572462 NA -0.5 -9.8 -0.36 3.14e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg00339695 chr16:24857497 SLC5A11 0.52 11.13 0.4 1.97e-26 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.38 8.07 0.3 3.38e-15 Schizophrenia; BRCA cis rs2014572 0.870 rs10426580 chr19:57756221 G/A cg24459738 chr19:57751996 ZNF805 -0.33 -7.98 -0.3 6.73e-15 Hyperactive-impulsive symptoms; BRCA cis rs7250872 0.647 rs2304613 chr19:1817943 G/C cg05970437 chr19:1864622 KLF16 0.44 8.19 0.31 1.43e-15 Bipolar disorder; BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.03 21.06 0.64 3.65e-75 Gut microbiome composition (summer); BRCA cis rs2839186 0.504 rs4347941 chr21:47938239 T/C cg12379764 chr21:47803548 PCNT 0.59 14.19 0.49 6.51e-40 Testicular germ cell tumor; BRCA cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.43e-19 Menopause (age at onset); BRCA trans rs9784649 0.891 rs57355285 chr5:25016384 C/G cg08600765 chr20:34638493 LOC647979 -0.58 -9.54 -0.35 2.86e-20 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9443645 0.527 rs2105143 chr6:79742947 G/A cg05283184 chr6:79620031 NA -0.36 -8.22 -0.31 1.13e-15 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg05234568 chr11:5960015 NA 0.61 13.78 0.48 5.05e-38 DNA methylation (variation); BRCA trans rs208520 1.000 rs12194996 chr6:66973366 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 11.89 0.43 1.3e-29 Exhaled nitric oxide output; BRCA cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.17 0.31 1.68e-15 Depression; BRCA cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.7800000000000005e-38 Mean platelet volume; BRCA cis rs9287719 0.967 rs4669598 chr2:10757838 T/C cg00105475 chr2:10696890 NA 0.44 10.29 0.38 4.38e-23 Prostate cancer; BRCA cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.03 0.4 4.9e-26 Bipolar disorder; BRCA trans rs11098499 0.691 rs12502524 chr4:120271414 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.63 0.39 2.12e-24 Corneal astigmatism; BRCA cis rs9811920 0.715 rs1017967 chr3:99905803 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.4 9.26 0.34 3.1400000000000002e-19 Axial length; BRCA cis rs7847628 0.587 rs3793638 chr9:123582697 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.84 20.32 0.63 3.42e-71 Birth weight; BRCA cis rs4478858 0.684 rs7519766 chr1:31735512 C/A cg00250761 chr1:31883323 NA -0.31 -8.13 -0.31 2.2e-15 Alcohol dependence; BRCA cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg14019146 chr3:50243930 SLC38A3 -0.45 -10.97 -0.4 9.23e-26 Body mass index; BRCA cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg05472934 chr7:22766657 IL6 0.58 15.07 0.51 4.08e-44 Lung cancer; BRCA cis rs919433 0.617 rs10931791 chr2:198573612 A/C cg00792783 chr2:198669748 PLCL1 -0.43 -9.56 -0.35 2.58e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs35306767 0.623 rs34034003 chr10:1143435 G/A cg26597838 chr10:835615 NA 0.69 11.22 0.41 8.64e-27 Eosinophil percentage of granulocytes; BRCA cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA trans rs35851103 0.507 rs6601649 chr8:11857317 A/G cg15556689 chr8:8085844 FLJ10661 -0.34 -9.0 -0.34 2.61e-18 Neuroticism; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg04944784 chr2:26401820 FAM59B -0.67 -11.31 -0.41 3.73e-27 Gut microbiome composition (summer); BRCA cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg05347473 chr6:146136440 FBXO30 0.43 8.74 0.33 2.04e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs9457247 0.765 rs6900701 chr6:167434112 A/G cg07741184 chr6:167504864 NA 0.28 8.19 0.31 1.48e-15 Crohn's disease; BRCA cis rs8054556 0.692 rs4788199 chr16:29970857 C/G cg06326092 chr16:30034487 C16orf92 0.35 8.75 0.33 1.82e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs8114671 0.562 rs4911164 chr20:33479488 G/C cg24642439 chr20:33292090 TP53INP2 0.41 8.09 0.3 3e-15 Height; BRCA cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg07930552 chr6:133119739 C6orf192 0.57 8.84 0.33 9.37e-18 Type 2 diabetes nephropathy; BRCA cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg23711669 chr6:146136114 FBXO30 -0.76 -17.63 -0.57 5.37e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs7512552 0.839 rs12045304 chr1:150399818 G/A cg15654264 chr1:150340011 RPRD2 0.41 8.81 0.33 1.19e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs1878931 0.597 rs37816 chr16:3456371 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.56 -9.24 -0.34 3.47e-19 Body mass index (adult); BRCA cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg08822215 chr16:89438651 ANKRD11 -0.44 -9.53 -0.35 3.13e-20 Multiple myeloma (IgH translocation); BRCA cis rs2243480 1.000 rs57057549 chr7:65405738 A/G cg18252515 chr7:66147081 NA -0.9 -12.94 -0.46 3.62e-34 Diabetic kidney disease; BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg11062466 chr8:58055876 NA 0.54 9.12 0.34 9.92e-19 Developmental language disorder (linguistic errors); BRCA cis rs9341808 0.905 rs3805903 chr6:80975829 T/C cg08355045 chr6:80787529 NA 0.33 8.62 0.32 5.28e-17 Sitting height ratio; BRCA cis rs7246657 0.943 rs10420754 chr19:37959372 C/G cg14683738 chr19:37701593 ZNF585B 0.45 7.95 0.3 8.32e-15 Coronary artery calcification; BRCA cis rs2836950 0.772 rs62222988 chr21:40569508 T/C cg17971929 chr21:40555470 PSMG1 -0.45 -9.27 -0.34 2.87e-19 Menarche (age at onset); BRCA cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg14530993 chr4:882597 GAK 0.53 9.8 0.36 3.34e-21 Intelligence (multi-trait analysis); BRCA cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.31 -7.85 -0.3 1.77e-14 Personality dimensions; BRCA cis rs7208859 0.673 rs11657270 chr17:29214387 A/G cg13385521 chr17:29058706 SUZ12P 0.62 8.52 0.32 1.15e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6089584 0.888 rs2181590 chr20:60622843 T/C cg13770153 chr20:60521292 NA -0.42 -9.39 -0.35 1.02e-19 Body mass index; BRCA cis rs6878727 0.665 rs698184 chr5:123664609 G/T cg01806427 chr5:123737813 NA 0.36 8.05 0.3 4.06e-15 Breast cancer; BRCA cis rs7666738 0.830 rs7657490 chr4:99043973 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.743 rs1292339 chr6:145967086 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -17.4 -0.57 8.82e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs57590327 0.555 rs13088603 chr3:81791167 A/G cg07356753 chr3:81810745 GBE1 -0.47 -11.24 -0.41 7.08e-27 Extraversion; BRCA cis rs73086581 0.945 rs6052222 chr20:3972793 G/A cg02187196 chr20:3869020 PANK2 0.5 8.79 0.33 1.37e-17 Response to antidepressants in depression; BRCA cis rs11585357 0.947 rs11585118 chr1:17605774 C/A cg08277548 chr1:17600880 PADI3 -0.74 -12.09 -0.43 1.9e-30 Hair shape; BRCA cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg18761221 chr20:60518478 NA -0.32 -8.07 -0.3 3.51e-15 Obesity-related traits; BRCA cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.86 0.42 1.86e-29 Homoarginine levels; BRCA cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.56 -0.32 8.48e-17 Electroencephalogram traits; BRCA cis rs1451375 0.617 rs17733244 chr7:50575495 T/C cg18232548 chr7:50535776 DDC 0.49 9.22 0.34 4.36e-19 Malaria; BRCA cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg18876405 chr7:65276391 NA 0.54 12.53 0.44 2.39e-32 Aortic root size; BRCA cis rs10911232 0.507 rs6664995 chr1:183017345 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 16.91 0.56 2.59e-53 Hypertriglyceridemia; BRCA cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg08085267 chr17:45401833 C17orf57 0.67 14.82 0.51 6.55e-43 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs312273 0.806 rs4767994 chr12:41349738 A/G cg17827154 chr12:41323612 CNTN1 -0.42 -10.98 -0.4 8.04e-26 Bipolar disorder; BRCA cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.45 0.5 3.54e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6964587 0.967 rs1978061 chr7:91779242 G/A cg17063962 chr7:91808500 NA 0.6 14.47 0.5 2.89e-41 Breast cancer; BRCA cis rs4268898 0.722 rs2288072 chr2:24390517 G/A cg26838691 chr2:24397539 C2orf84 0.4 8.01 0.3 5.49e-15 Asthma; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg03923535 chr7:1197113 ZFAND2A 0.52 11.36 0.41 2.28e-27 Longevity;Endometriosis; BRCA cis rs992157 0.835 rs34353396 chr2:219153982 T/C cg00012203 chr2:219082015 ARPC2 -0.48 -9.23 -0.34 3.88e-19 Colorectal cancer; BRCA cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg08997352 chr12:9597637 DDX12 -0.57 -11.03 -0.4 5.25e-26 Breast size; BRCA cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg11657440 chr19:46296263 DMWD 0.71 19.07 0.6 1.69e-64 Coronary artery disease; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.02 -0.34 2.26e-18 Total body bone mineral density; BRCA cis rs12950390 0.853 rs56137679 chr17:45862112 C/G cg24803719 chr17:45855879 NA -0.31 -8.05 -0.3 4.15e-15 IgG glycosylation; BRCA cis rs4919694 1.000 rs12268849 chr10:104737682 G/A cg04362960 chr10:104952993 NT5C2 0.9 14.85 0.51 4.46e-43 Arsenic metabolism; BRCA cis rs2637266 1.000 rs12784382 chr10:78378348 G/T cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg10729496 chr3:10149963 C3orf24 0.45 8.7 0.33 2.8e-17 Alzheimer's disease; BRCA cis rs796364 1.000 rs281759 chr2:200787719 T/C cg23649088 chr2:200775458 C2orf69 0.59 8.81 0.33 1.18e-17 Schizophrenia; BRCA cis rs6942756 0.876 rs28636722 chr7:129015151 C/T cg02491457 chr7:128862824 NA -0.61 -12.55 -0.44 1.83e-32 White matter hyperintensity burden; BRCA cis rs6546886 0.912 rs10191539 chr2:74269926 T/C cg14702570 chr2:74259524 NA -0.32 -8.03 -0.3 4.83e-15 Dialysis-related mortality; BRCA cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg20503657 chr10:835505 NA 0.95 14.3 0.49 1.8e-40 Eosinophil percentage of granulocytes; BRCA cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg02153584 chr22:29168773 CCDC117 0.54 11.36 0.41 2.28e-27 Lymphocyte counts; BRCA cis rs9611519 0.929 rs4821991 chr22:41440683 T/C cg03806693 chr22:41940476 POLR3H -0.55 -9.72 -0.36 6.52e-21 Neuroticism; BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg04267008 chr7:1944627 MAD1L1 -0.41 -8.89 -0.33 6.29e-18 Schizophrenia; BRCA cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg18357645 chr12:58087776 OS9 0.3 7.97 0.3 7.12e-15 Multiple sclerosis; BRCA cis rs17125944 0.505 rs10483617 chr14:53202605 A/G cg00686598 chr14:53173677 PSMC6 -1.23 -16.24 -0.54 6.87e-50 Alzheimer's disease (late onset); BRCA cis rs1707322 0.752 rs10430105 chr1:46138876 G/A cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg08807101 chr21:30365312 RNF160 0.75 19.55 0.61 4.56e-67 Dental caries; BRCA cis rs61931739 0.500 rs7295779 chr12:34460652 T/C cg06521331 chr12:34319734 NA -0.5 -9.78 -0.36 3.81e-21 Morning vs. evening chronotype; BRCA cis rs2011503 0.941 rs55762233 chr19:19367319 C/G cg15839431 chr19:19639596 YJEFN3 -0.35 -7.99 -0.3 6.53e-15 Bipolar disorder; BRCA cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg27102117 chr16:15229624 NA 0.41 9.98 0.37 6.83e-22 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs8062405 1.000 rs4451951 chr16:28836205 T/C cg09719594 chr16:21412588 NA -0.32 -7.81 -0.3 2.33e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg24296786 chr1:45957014 TESK2 0.63 15.73 0.53 2.31e-47 High light scatter reticulocyte count; BRCA cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg06115741 chr20:33292138 TP53INP2 0.35 7.89 0.3 1.29e-14 Glomerular filtration rate (creatinine); BRCA cis rs7267979 0.932 rs6107052 chr20:25530838 G/A cg08601574 chr20:25228251 PYGB 0.34 8.27 0.31 7.63e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13126279 chr21:47581558 C21orf56 0.43 9.52 0.35 3.5e-20 Testicular germ cell tumor; BRCA cis rs11098499 0.954 rs1022145 chr4:120230979 A/G cg09307838 chr4:120376055 NA 0.7 14.46 0.5 3.32e-41 Corneal astigmatism; BRCA cis rs7572733 0.555 rs1435569 chr2:198718667 G/C cg00792783 chr2:198669748 PLCL1 0.47 10.12 0.37 1.95e-22 Dermatomyositis; BRCA cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg14844989 chr11:31128820 NA 0.46 9.59 0.35 1.95e-20 Red blood cell count; BRCA trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg08975724 chr8:8085496 FLJ10661 -0.42 -8.13 -0.31 2.19e-15 Retinal vascular caliber; BRCA cis rs427394 0.659 rs274695 chr5:6732252 G/C cg10857441 chr5:6722123 POLS -0.31 -9.89 -0.36 1.46e-21 Menopause (age at onset); BRCA cis rs61931739 0.500 rs11053222 chr12:34481100 C/A cg06521331 chr12:34319734 NA -0.56 -10.18 -0.37 1.14e-22 Morning vs. evening chronotype; BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg07389463 chr12:132296394 NA 0.33 8.82 0.33 1.1e-17 Migraine; BRCA cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg25173405 chr17:45401733 C17orf57 -0.52 -10.74 -0.39 7.82e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs1459104 0.866 rs35456973 chr11:54838812 C/A cg15704280 chr7:45808275 SEPT13 0.63 8.27 0.31 7.96e-16 Body mass index; BRCA cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs6138458 1.000 rs227621 chr20:24910528 A/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.38 -0.31 3.34e-16 Blood protein levels; BRCA cis rs1577917 1.000 rs35760725 chr6:86648985 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.39 -0.41 1.76e-27 Response to antipsychotic treatment; BRCA cis rs4727443 0.866 rs6963345 chr7:99618606 G/A cg22004693 chr7:99632812 ZKSCAN1 0.4 8.99 0.34 2.73e-18 Interstitial lung disease; BRCA cis rs57590327 0.528 rs3821552 chr3:81702139 A/G cg07356753 chr3:81810745 GBE1 -0.42 -9.51 -0.35 3.85e-20 Extraversion; BRCA cis rs1865760 0.865 rs1115920 chr6:25954027 A/G cg16482183 chr6:26056742 HIST1H1C 0.49 10.19 0.37 1.07e-22 Height; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg05863683 chr7:1912471 MAD1L1 0.43 9.17 0.34 6.54e-19 Bipolar disorder and schizophrenia; BRCA cis rs514406 0.565 rs897732 chr1:53382816 A/C cg16325326 chr1:53192061 ZYG11B 0.52 11.12 0.4 2.15e-26 Monocyte count; BRCA cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg15017067 chr4:17643749 FAM184B 0.34 10.76 0.39 6.45e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.54 14.15 0.49 1e-39 Response to bleomycin (chromatid breaks); BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg13628971 chr7:2884303 GNA12 0.49 9.69 0.36 8.11e-21 Height; BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg08805041 chr16:621841 PIGQ -0.3 -7.94 -0.3 8.93e-15 Height; BRCA cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg08045932 chr20:61659980 NA 0.47 10.37 0.38 2.13e-23 Prostate cancer (SNP x SNP interaction); BRCA cis rs2882667 0.690 rs10067361 chr5:138240874 G/T cg04439458 chr5:138467593 SIL1 -0.34 -8.36 -0.31 4.05e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs11105298 0.891 rs1008764 chr12:89887649 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -9.98 -0.37 7.04e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs35110281 0.782 rs9981790 chr21:45045052 G/C cg04455712 chr21:45112962 RRP1B 0.41 10.99 0.4 7.35e-26 Mean corpuscular volume; BRCA trans rs7618501 0.633 rs6446189 chr3:50008566 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.31 0.35 2.08e-19 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs2624839 0.679 rs2624835 chr3:50209049 G/A cg14019146 chr3:50243930 SLC38A3 -0.64 -15.7 -0.53 3.25e-47 Intelligence (multi-trait analysis); BRCA cis rs2290405 0.527 rs6829987 chr4:932974 C/G cg04824913 chr4:887549 GAK -0.72 -13.47 -0.47 1.47e-36 Systemic sclerosis; BRCA cis rs7493 0.950 rs17166868 chr7:95033416 C/T cg21856205 chr7:94953877 PON1 -0.37 -7.82 -0.3 2.18e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs11030122 0.645 rs11493482 chr11:4034772 A/G cg18678763 chr11:4115507 RRM1 -0.35 -7.9 -0.3 1.21e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg06636001 chr8:8085503 FLJ10661 0.64 14.37 0.49 9.01e-41 Mood instability; BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.11 0.31 2.54e-15 Tonsillectomy; BRCA cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg23711669 chr6:146136114 FBXO30 -0.75 -17.18 -0.56 1.18e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs2243480 0.901 rs13237344 chr7:66022256 T/A cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.29e-47 Diabetic kidney disease; BRCA trans rs6952808 0.723 rs4721282 chr7:2025040 A/G cg04565464 chr8:145669602 NFKBIL2 0.34 8.06 0.3 3.7e-15 Bipolar disorder and schizophrenia; BRCA cis rs7945718 1.000 rs12269900 chr11:12748518 G/A cg25843174 chr11:12811716 TEAD1 0.23 8.49 0.32 1.4e-16 Educational attainment (years of education); BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg11843238 chr5:131593191 PDLIM4 0.37 9.62 0.36 1.56e-20 Breast cancer; BRCA cis rs7914558 1.000 rs10748838 chr10:104943986 T/A cg04362960 chr10:104952993 NT5C2 0.43 10.25 0.38 6.42e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2050392 0.517 rs656600 chr10:30765654 G/A cg18806716 chr10:30721971 MAP3K8 -0.44 -9.99 -0.37 6.14e-22 Inflammatory bowel disease; BRCA cis rs3818285 1.000 rs3818285 chr10:111635212 T/C cg00817464 chr10:111662876 XPNPEP1 -0.34 -8.72 -0.33 2.39e-17 Superior crus of antihelix expression; BRCA cis rs11098499 0.955 rs4145951 chr4:120155817 A/G cg09307838 chr4:120376055 NA 0.61 11.91 0.43 1.15e-29 Corneal astigmatism; BRCA cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg12311346 chr5:56204834 C5orf35 -0.58 -11.46 -0.41 8.62e-28 Type 2 diabetes; BRCA cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg18538332 chr22:24372958 LOC391322 -0.56 -14.13 -0.49 1.17e-39 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg00631329 chr6:26305371 NA -0.45 -13.67 -0.48 1.66e-37 Educational attainment; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg03188948 chr7:1209495 NA 0.86 11.76 0.42 4.8e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg16339924 chr4:17578868 LAP3 -0.56 -13.25 -0.46 1.42e-35 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7772486 0.875 rs2748483 chr6:146335560 A/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.95 -0.3 8.45e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg04756594 chr16:24857601 SLC5A11 -0.55 -12.43 -0.44 6.24e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs1577917 1.000 rs35385043 chr6:86648546 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.39 -0.41 1.76e-27 Response to antipsychotic treatment; BRCA cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.32 0.31 5.33e-16 Menopause (age at onset); BRCA cis rs6840258 0.660 rs55816619 chr4:87959805 G/A cg08197287 chr4:87952173 AFF1 -0.48 -8.15 -0.31 1.88e-15 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs6138458 0.626 rs6138473 chr20:25012155 A/G cg26195577 chr20:24973756 C20orf3 -0.57 -14.19 -0.49 5.97e-40 Blood protein levels; BRCA cis rs4713118 0.868 rs7756968 chr6:27734954 C/G cg20933634 chr6:27740509 NA 0.47 8.93 0.33 4.57e-18 Parkinson's disease; BRCA cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4595586 0.545 rs2197941 chr12:39402223 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.43 0.35 7.36e-20 Morning vs. evening chronotype; BRCA cis rs1003719 0.751 rs55992706 chr21:38542749 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.42 -0.5 5.11e-41 Eye color traits; BRCA cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg09467607 chr2:36825704 FEZ2 0.67 17.89 0.58 2.62e-58 Height; BRCA cis rs9512730 0.553 rs9512702 chr13:28033485 A/G cg08193333 chr13:27998609 GTF3A 0.41 7.89 0.3 1.31e-14 Schizophrenia; BRCA cis rs881375 0.967 rs1860824 chr9:123659339 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.83 0.39 3.26e-25 Rheumatoid arthritis; BRCA trans rs1493916 0.721 rs4799723 chr18:31367050 T/G cg15819921 chr19:927150 ARID3A -0.53 -9.83 -0.36 2.39e-21 Life satisfaction; BRCA cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg13770153 chr20:60521292 NA -0.46 -10.9 -0.4 1.66e-25 Body mass index; BRCA cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg01028140 chr2:1542097 TPO -0.6 -12.64 -0.45 7.84e-33 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6088813 1.000 rs1570004 chr20:33958253 A/T cg14752227 chr20:34000481 UQCC -0.39 -8.27 -0.31 7.69e-16 Height; BRCA cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg17892150 chr10:133769511 PPP2R2D -0.72 -15.45 -0.52 5.26e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs9473147 0.516 rs9349413 chr6:47511491 A/G cg12968598 chr6:47444699 CD2AP 0.49 9.82 0.36 2.62e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs4363385 0.818 rs370162 chr1:153005488 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.7 -11.85 -0.42 1.96e-29 Platelet count; BRCA cis rs12545109 0.800 rs990301 chr8:57406021 G/C cg09654669 chr8:57350985 NA -0.38 -8.24 -0.31 9.83e-16 Obesity-related traits; BRCA cis rs6748734 1.000 rs4675874 chr2:241819796 A/G cg02820040 chr2:241836501 C2orf54 0.5 9.03 0.34 1.97e-18 Urinary metabolites; BRCA cis rs10197940 0.550 rs77233070 chr2:152416477 G/A cg19508488 chr2:152266495 RIF1 0.47 9.4 0.35 9.32e-20 Lung cancer; BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg22920501 chr2:26401640 FAM59B -0.95 -16.5 -0.55 3.18e-51 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg04944784 chr2:26401820 FAM59B 1.0 16.5 0.55 3.29e-51 Gut microbiome composition (summer); BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg00802000 chr16:706648 WDR90 -0.4 -9.31 -0.35 2.04e-19 Height; BRCA cis rs2806561 0.514 rs10917360 chr1:23539010 C/T cg24466277 chr1:23519622 HTR1D -0.39 -8.56 -0.32 8.26e-17 Height; BRCA cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -10.89 -0.4 1.97e-25 Mood instability; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.57 8.98 0.33 2.91e-18 Renal function-related traits (BUN); BRCA cis rs6005807 0.719 rs12169880 chr22:29054875 G/C cg12565055 chr22:29076175 TTC28 0.5 9.47 0.35 5.27e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs4589502 0.557 rs2447300 chr15:67180599 C/T cg09911534 chr15:67153556 NA -0.47 -8.15 -0.31 1.86e-15 Lung cancer (smoking interaction); BRCA cis rs4820539 0.934 rs3788348 chr22:23467946 G/C cg14186256 chr22:23484241 RTDR1 0.78 23.94 0.69 6.75e-91 Bone mineral density; BRCA cis rs3780378 0.967 rs10815144 chr9:5010192 C/T cg02405213 chr9:5042618 JAK2 -0.44 -8.95 -0.33 3.7e-18 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs12458462 0.892 rs2242174 chr18:77458037 T/C cg11879182 chr18:77439856 CTDP1 0.65 14.01 0.48 4.41e-39 Monocyte count; BRCA cis rs2243480 1.000 rs2465120 chr7:65620974 C/G cg18252515 chr7:66147081 NA -1.03 -15.25 -0.52 5.04e-45 Diabetic kidney disease; BRCA cis rs11098499 0.866 rs7665125 chr4:120402079 G/T cg09307838 chr4:120376055 NA 0.66 14.48 0.5 2.78e-41 Corneal astigmatism; BRCA cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.82 0.36 2.79e-21 Lung cancer in ever smokers; BRCA cis rs826838 1.000 rs826886 chr12:39095797 A/G cg13010199 chr12:38710504 ALG10B 0.44 10.04 0.37 4.14e-22 Heart rate; BRCA cis rs6815814 0.950 rs11722889 chr4:38810975 C/T cg02016764 chr4:38805732 TLR1 -0.6 -9.25 -0.34 3.22e-19 Breast cancer; BRCA cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg06238570 chr21:40685208 BRWD1 -0.39 -7.9 -0.3 1.2e-14 Menarche (age at onset); BRCA cis rs8044868 0.548 rs3909541 chr16:72201119 C/T cg16558253 chr16:72132732 DHX38 0.42 10.3 0.38 4.02e-23 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs9287719 0.967 rs6759100 chr2:10746710 A/G cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg22535103 chr8:58192502 C8orf71 -0.61 -13.4 -0.47 2.92e-36 Developmental language disorder (linguistic errors); BRCA cis rs2230307 0.536 rs560659 chr1:100523536 A/G cg24955406 chr1:100503596 HIAT1 -0.56 -11.18 -0.4 1.28e-26 Carotid intima media thickness; BRCA trans rs11098499 0.754 rs1546503 chr4:120241167 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.3 0.38 4.02e-23 Corneal astigmatism; BRCA cis rs2712381 0.517 rs62273237 chr3:128310107 T/C cg16766828 chr3:128327626 NA -0.34 -7.87 -0.3 1.55e-14 Monocyte count; BRCA cis rs9875589 0.957 rs4407395 chr3:13951673 A/G cg19554555 chr3:13937349 NA 0.43 8.98 0.33 2.92e-18 Ovarian reserve; BRCA cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg26031613 chr14:104095156 KLC1 -0.53 -9.47 -0.35 5.48e-20 Reticulocyte count; BRCA cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg20607287 chr7:12443886 VWDE -0.58 -8.42 -0.32 2.54e-16 Coronary artery disease; BRCA trans rs931812 0.829 rs13266662 chr8:101916156 C/T cg20993868 chr7:22813445 NA 0.44 12.87 0.45 7.27e-34 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs9811920 0.609 rs4928232 chr3:99694217 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.71 -16.47 -0.55 4.77e-51 Axial length; BRCA cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.23e-36 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.632 rs61461940 chr9:5157277 T/C cg02405213 chr9:5042618 JAK2 -0.52 -10.26 -0.38 5.82e-23 Pediatric autoimmune diseases; BRCA cis rs10044254 0.614 rs35167698 chr5:15737297 T/C cg07238450 chr5:15720153 FBXL7 -0.38 -8.08 -0.3 3.26e-15 Asthma (corticosteroid response); BRCA cis rs826838 0.967 rs980572 chr12:39127673 A/C cg26384229 chr12:38710491 ALG10B 0.62 16.43 0.54 7.77e-51 Heart rate; BRCA cis rs2882667 0.591 rs56322405 chr5:138173382 C/G cg04439458 chr5:138467593 SIL1 0.31 7.83 0.3 2.05e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg14835575 chr10:16859367 RSU1 0.66 14.03 0.49 3.44e-39 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg05623727 chr3:50126028 RBM5 0.43 10.14 0.37 1.71e-22 Intelligence (multi-trait analysis); BRCA cis rs55665837 0.559 rs9667144 chr11:14421101 C/T cg19336497 chr11:14380999 RRAS2 0.45 11.87 0.43 1.61e-29 Vitamin D levels; BRCA cis rs2197308 0.606 rs12314897 chr12:38392293 C/T cg26384229 chr12:38710491 ALG10B -0.43 -10.01 -0.37 5.12e-22 Morning vs. evening chronotype; BRCA cis rs7666738 0.791 rs13125277 chr4:99009922 T/G cg03676636 chr4:99064102 C4orf37 0.21 7.97 0.3 7.55e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs1005277 0.528 rs2057228 chr10:38515766 T/C cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.65e-33 Extrinsic epigenetic age acceleration; BRCA cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg01017244 chr2:74357527 NA 0.53 12.71 0.45 3.81e-33 Gestational age at birth (maternal effect); BRCA cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg26874164 chr19:58962979 ZNF324B 0.51 11.01 0.4 6.36e-26 Uric acid clearance; BRCA cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.27 0.44 3.23e-31 Tonsillectomy; BRCA cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg02153584 chr22:29168773 CCDC117 0.44 7.9 0.3 1.19e-14 Lymphocyte counts; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg04518342 chr5:131593106 PDLIM4 0.42 10.1 0.37 2.41e-22 Acylcarnitine levels; BRCA cis rs1153858 1.000 rs4271549 chr15:45652730 G/A cg21132104 chr15:45694354 SPATA5L1 0.75 17.12 0.56 2.4e-54 Homoarginine levels; BRCA cis rs4891159 0.527 rs690593 chr18:74160408 C/G cg24786174 chr18:74118243 ZNF516 0.76 20.91 0.64 2.29e-74 Longevity; BRCA cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg20790798 chr5:1857306 NA -0.4 -9.39 -0.35 1.04e-19 Cardiovascular disease risk factors; BRCA cis rs17092148 1.000 rs11699062 chr20:33400379 A/T cg16810054 chr20:33298113 TP53INP2 0.5 11.25 0.41 6.79e-27 Neuroticism; BRCA cis rs12468557 0.545 rs7587701 chr2:211499959 A/G cg07063745 chr2:211341572 LANCL1;CPS1 -0.36 -8.04 -0.3 4.44e-15 Body mass index in asthmatics; BRCA cis rs10461617 0.541 rs860581 chr5:56150537 A/G cg18230493 chr5:56204884 C5orf35 -0.65 -10.43 -0.38 1.24e-23 Type 2 diabetes; BRCA cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg08999081 chr20:33150536 PIGU 0.47 12.86 0.45 7.97e-34 Glomerular filtration rate (creatinine); BRCA cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs7582180 0.629 rs11685250 chr2:100955137 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.73 0.42 6.37e-29 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.766 rs4679050 chr3:38482007 G/A cg24069376 chr3:38537580 EXOG 0.34 9.41 0.35 8.96e-20 Electrocardiographic conduction measures; BRCA cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg09035930 chr12:129282057 SLC15A4 -0.46 -12.08 -0.43 2.08e-30 Systemic lupus erythematosus; BRCA cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg07606381 chr6:8435919 SLC35B3 0.64 14.37 0.49 9.05e-41 Motion sickness; BRCA cis rs849141 0.925 rs552707 chr7:28205303 A/G cg22892036 chr7:28189139 JAZF1 0.45 8.19 0.31 1.44e-15 Height;Hip circumference adjusted for BMI; BRCA cis rs9790314 0.905 rs7633186 chr3:161003124 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.28 -0.49 2.26e-40 Morning vs. evening chronotype; BRCA cis rs2882667 0.690 rs288004 chr5:138231645 C/T cg04439458 chr5:138467593 SIL1 -0.31 -7.82 -0.3 2.22e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg25817165 chr18:72167213 CNDP2 -0.73 -14.1 -0.49 1.59e-39 Refractive error; BRCA cis rs2073300 1.000 rs6132623 chr20:23442324 T/A cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4730250 0.708 rs74983157 chr7:106823951 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.51 -0.32 1.24e-16 Osteoarthritis; BRCA cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.64e-24 Motion sickness; BRCA cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.13 0.4 2.01e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6582630 0.599 rs12309369 chr12:38419683 C/G cg26384229 chr12:38710491 ALG10B -0.43 -9.82 -0.36 2.68e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs853679 0.517 rs3734573 chr6:28059437 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.17e-15 Depression; BRCA cis rs2797160 1.000 rs1418642 chr6:125999768 G/A cg05901451 chr6:126070800 HEY2 -0.39 -9.33 -0.35 1.66e-19 Endometrial cancer; BRCA trans rs12458462 0.859 rs35493271 chr18:77448793 G/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -8.63 -0.32 5.01e-17 Monocyte count; BRCA cis rs1113500 0.787 rs10881502 chr1:108641819 C/T cg06207961 chr1:108661230 NA -0.37 -9.14 -0.34 8.01e-19 Growth-regulated protein alpha levels; BRCA cis rs7945705 0.791 rs12421789 chr11:8813956 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -10.81 -0.39 3.83e-25 Hemoglobin concentration; BRCA cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg23711669 chr6:146136114 FBXO30 0.74 16.82 0.55 7.41e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs6429082 0.783 rs291365 chr1:235688043 A/G cg26050004 chr1:235667680 B3GALNT2 0.55 14.4 0.5 6.12e-41 Adiposity; BRCA trans rs9467711 0.659 rs36162392 chr6:26569135 T/C cg01620082 chr3:125678407 NA -0.69 -8.61 -0.32 5.8e-17 Autism spectrum disorder or schizophrenia; BRCA trans rs1945213 0.694 rs12422168 chr11:55866840 A/G cg03929089 chr4:120376271 NA 0.57 9.82 0.36 2.63e-21 Acute lymphoblastic leukemia (childhood); BRCA cis rs708547 0.792 rs7667084 chr4:57727435 T/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.48 -10.79 -0.39 4.72e-25 Response to bleomycin (chromatid breaks); BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.78 -13.99 -0.48 5.22e-39 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7071206 0.947 rs10824560 chr10:79416901 C/T cg07817648 chr10:79422355 NA -0.67 -12.49 -0.44 3.56e-32 Bone mineral density; BRCA cis rs7772486 0.875 rs863820 chr6:146347402 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -8.35 -0.31 4.17e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11583043 0.918 rs56402739 chr1:101397133 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.7 0.36 7.47e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs172166 0.652 rs476167 chr6:28065888 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.92 0.3 1.07e-14 Cardiac Troponin-T levels; BRCA trans rs11098499 0.954 rs1480931 chr4:120395809 G/T cg25214090 chr10:38739885 LOC399744 0.54 12.29 0.44 2.66e-31 Corneal astigmatism; BRCA cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg20503657 chr10:835505 NA -1.0 -15.33 -0.52 2.04e-45 Eosinophil percentage of granulocytes; BRCA cis rs12497850 0.765 rs12487580 chr3:49182932 G/A cg06212747 chr3:49208901 KLHDC8B 0.53 11.11 0.4 2.43e-26 Parkinson's disease; BRCA cis rs6893300 0.745 rs6639 chr5:179156782 G/T cg14593053 chr5:179126677 CANX -0.35 -7.9 -0.3 1.25e-14 Resting heart rate; BRCA cis rs10751667 0.961 rs10902263 chr11:992691 A/C cg01483505 chr11:975446 AP2A2 -0.32 -8.67 -0.32 3.43e-17 Alzheimer's disease (late onset); BRCA cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.64 -0.36 1.32e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs16910800 0.731 rs1065631 chr11:23186810 T/C cg20040320 chr11:23191996 NA -0.58 -10.03 -0.37 4.27e-22 Cancer; BRCA cis rs12540874 0.542 rs4947581 chr7:50565967 G/A cg18232548 chr7:50535776 DDC -0.51 -12.91 -0.45 4.58e-34 Systemic sclerosis; BRCA cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg15595755 chr5:1867978 NA 0.35 8.27 0.31 7.67e-16 Cardiovascular disease risk factors; BRCA cis rs4566357 0.615 rs10178098 chr2:227914425 C/T cg05526886 chr2:227700861 RHBDD1 -0.39 -8.2 -0.31 1.31e-15 Coronary artery disease; BRCA cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg26343298 chr8:95960752 TP53INP1 0.3 8.74 0.33 2.07e-17 Type 2 diabetes; BRCA cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg01579765 chr21:45077557 HSF2BP -0.44 -11.96 -0.43 6.94e-30 Mean corpuscular volume; BRCA cis rs6121246 0.779 rs6060763 chr20:30282223 A/G cg21427119 chr20:30132790 HM13 -0.4 -8.56 -0.32 8.62e-17 Mean corpuscular hemoglobin; BRCA cis rs11792861 0.591 rs7044275 chr9:111717138 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 12.99 0.46 2.17e-34 Menarche (age at onset); BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg08470875 chr2:26401718 FAM59B 0.76 12.04 0.43 3.12e-30 Gut microbiome composition (summer); BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg04944784 chr2:26401820 FAM59B 0.97 16.04 0.54 6.42e-49 Gut microbiome composition (summer); BRCA cis rs4363385 0.791 rs512198 chr1:153006245 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.24 -0.34 3.58e-19 Inflammatory skin disease; BRCA trans rs61931739 0.500 rs7306053 chr12:34510848 T/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.04e-18 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26314531 chr2:26401878 FAM59B -0.63 -11.02 -0.4 5.65e-26 Gut microbiome composition (summer); BRCA cis rs9469890 0.604 rs11758426 chr6:34503338 A/G cg17674042 chr6:34482479 PACSIN1 -0.34 -8.94 -0.33 4.18e-18 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs701145 0.938 rs355780 chr3:153978289 C/T cg17054900 chr3:154042577 DHX36 0.62 11.02 0.4 5.4e-26 Coronary artery disease; BRCA cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.05 0.56 5.25e-54 Bladder cancer; BRCA cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs8002861 0.781 rs9525857 chr13:44437072 T/C cg17145862 chr1:211918768 LPGAT1 0.63 16.2 0.54 1.07e-49 Leprosy; BRCA cis rs7474896 0.537 rs598857 chr10:38302926 A/G cg25427524 chr10:38739819 LOC399744 0.51 9.43 0.35 7.31e-20 Obesity (extreme); BRCA cis rs35110281 0.594 rs230641 chr21:44915441 T/C cg21573476 chr21:45109991 RRP1B 0.32 8.11 0.31 2.64e-15 Mean corpuscular volume; BRCA cis rs4285028 0.747 rs77570895 chr3:121384565 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.85 -14.99 -0.51 9.27e-44 Multiple sclerosis; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg04234412 chr22:24373322 LOC391322 0.78 21.67 0.65 1.68e-78 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.37 8.11 0.31 2.58e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9469578 1.000 rs16869466 chr6:33715265 A/G cg18708504 chr6:33715942 IP6K3 0.7 10.19 0.37 1.09e-22 Phosphorus levels; BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg22963979 chr7:1858916 MAD1L1 -0.42 -8.78 -0.33 1.55e-17 Bipolar disorder and schizophrenia; BRCA cis rs4663866 0.901 rs2304672 chr2:239186589 C/G cg16914508 chr2:239161102 PER2 -0.68 -9.38 -0.35 1.1e-19 Irritable bowel syndrome; BRCA cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg24531977 chr5:56204891 C5orf35 -0.86 -17.89 -0.58 2.57e-58 Initial pursuit acceleration; BRCA cis rs5167 0.504 rs73047641 chr19:45457377 G/A cg13119609 chr19:45449297 APOC2 0.46 12.78 0.45 1.91e-33 Blood protein levels; BRCA cis rs6762477 0.505 rs17304079 chr3:50085153 A/G cg14019146 chr3:50243930 SLC38A3 -0.57 -11.8 -0.42 3.32e-29 Menarche (age at onset); BRCA cis rs2742417 0.603 rs2742456 chr3:45767176 C/T cg04837898 chr3:45731254 SACM1L -0.39 -7.93 -0.3 9.97e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg13073564 chr4:8508604 NA 0.46 12.37 0.44 1.22e-31 Response to antineoplastic agents; BRCA cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg27478167 chr7:817139 HEATR2 -0.57 -11.58 -0.42 2.69e-28 Cerebrospinal P-tau181p levels; BRCA trans rs11039798 0.582 rs1304193 chr11:48688588 C/T cg03929089 chr4:120376271 NA 0.57 9.25 0.34 3.26e-19 Axial length; BRCA cis rs7568458 0.684 rs60012532 chr2:85752474 A/C cg02493740 chr2:85810744 VAMP5 -0.5 -10.23 -0.38 7.55e-23 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9287719 0.624 rs10211190 chr2:10725428 A/G cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs2425143 0.512 rs2425126 chr20:34331730 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.07 -0.43 2.22e-30 Blood protein levels; BRCA cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs67340775 0.748 rs13212651 chr6:27806985 A/G cg01620082 chr3:125678407 NA -0.91 -10.37 -0.38 2.19e-23 Lung cancer in ever smokers; BRCA cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg16506815 chr2:162101123 NA 0.47 10.08 0.37 2.9e-22 Intelligence (multi-trait analysis); BRCA cis rs2795502 0.938 rs2744085 chr10:43341976 C/T cg20628663 chr10:43360327 NA 0.7 13.59 0.47 3.95e-37 Blood protein levels; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg11843238 chr5:131593191 PDLIM4 0.38 9.26 0.34 3.01e-19 Acylcarnitine levels; BRCA cis rs367943 0.966 rs451425 chr5:112808637 A/G cg12552261 chr5:112820674 MCC -0.55 -12.22 -0.44 4.98e-31 Type 2 diabetes; BRCA trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -8.76 -0.33 1.74e-17 Triglycerides; BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg10729496 chr3:10149963 C3orf24 0.49 9.26 0.34 2.95e-19 Alzheimer's disease; BRCA cis rs7523050 0.643 rs17621851 chr1:109400835 C/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg07395648 chr5:131743802 NA -0.37 -8.07 -0.3 3.54e-15 Breast cancer; BRCA cis rs7647973 0.626 rs2131108 chr3:49665390 C/T cg03060546 chr3:49711283 APEH 0.58 9.93 0.37 1.08e-21 Menarche (age at onset); BRCA trans rs7618501 1.000 rs11130218 chr3:49752372 C/T cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.32 -0.38 3.46e-23 Intelligence (multi-trait analysis); BRCA trans rs7647973 0.626 rs9830730 chr3:49675875 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.81 -0.3 2.3e-14 Menarche (age at onset); BRCA cis rs61931739 0.517 rs10844830 chr12:34308133 C/T cg06521331 chr12:34319734 NA -0.68 -14.95 -0.51 1.46e-43 Morning vs. evening chronotype; BRCA cis rs6500602 0.648 rs7702 chr16:4560929 G/C cg08645402 chr16:4508243 NA 0.43 9.95 0.37 9.09e-22 Schizophrenia; BRCA cis rs40363 0.645 rs250633 chr16:3523002 C/T cg21433313 chr16:3507492 NAT15 0.45 10.16 0.37 1.36e-22 Tuberculosis; BRCA cis rs796364 0.950 rs188146 chr2:200750444 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.95 0.46 3.07e-34 Schizophrenia; BRCA cis rs6815814 0.950 rs66922907 chr4:38812537 A/G cg02016764 chr4:38805732 TLR1 -0.6 -9.19 -0.34 5.47e-19 Breast cancer; BRCA cis rs1891275 0.515 rs7092884 chr10:93483872 A/C cg07889827 chr10:93443413 NA 0.41 11.21 0.41 9.86e-27 Intelligence (multi-trait analysis); BRCA cis rs887829 0.570 rs6759892 chr2:234601669 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.32 8.33 0.31 4.95e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1008375 0.966 rs6832387 chr4:17697546 G/T cg02297831 chr4:17616191 MED28 0.36 8.55 0.32 8.99e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg20476274 chr7:133979776 SLC35B4 0.58 16.09 0.54 3.73e-49 Mean platelet volume; BRCA cis rs1577917 0.958 rs10944168 chr6:86680156 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.08 -0.3 3.32e-15 Response to antipsychotic treatment; BRCA cis rs9287719 0.967 rs6432126 chr2:10757101 A/G cg00105475 chr2:10696890 NA 0.44 10.3 0.38 4.11e-23 Prostate cancer; BRCA cis rs9858542 1.000 rs2172252 chr3:49678307 A/T cg03060546 chr3:49711283 APEH -0.6 -11.69 -0.42 9.46e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs3857536 0.566 rs208463 chr6:66913962 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.55 -10.39 -0.38 1.8e-23 Blood trace element (Cu levels); BRCA cis rs9443189 0.530 rs614065 chr6:76315633 G/A cg01950844 chr6:76311363 SENP6 0.86 13.95 0.48 8.14e-39 Prostate cancer; BRCA cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg11663144 chr21:46675770 NA -0.62 -14.66 -0.5 3.53e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9394841 0.667 rs9357366 chr6:41786976 T/G cg08135965 chr6:41755394 TOMM6 0.47 7.82 0.3 2.19e-14 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg05347473 chr6:146136440 FBXO30 0.41 8.1 0.31 2.78e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7264396 0.747 rs2425112 chr20:34319775 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -16.2 -0.54 9.96e-50 Total cholesterol levels; BRCA cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg15556689 chr8:8085844 FLJ10661 0.37 10.48 0.38 8.23e-24 Joint mobility (Beighton score); BRCA cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg21132104 chr15:45694354 SPATA5L1 0.75 16.89 0.56 3.4e-53 Homoarginine levels; BRCA cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg11764359 chr7:65958608 NA 0.46 8.97 0.33 3.18e-18 Calcium levels; BRCA cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg06618935 chr21:46677482 NA -0.36 -8.0 -0.3 5.83e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg17366294 chr4:99064904 C4orf37 -0.44 -10.63 -0.39 2.09e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6088813 1.000 rs4911180 chr20:33972948 G/A cg14752227 chr20:34000481 UQCC -0.4 -8.46 -0.32 1.77e-16 Height; BRCA cis rs61990749 0.597 rs2267758 chr14:78147429 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.63 -9.61 -0.36 1.65e-20 Fibroblast growth factor basic levels; BRCA cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg18876405 chr7:65276391 NA 0.41 8.66 0.32 3.87e-17 Aortic root size; BRCA cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg23719950 chr11:63933701 MACROD1 -0.61 -9.74 -0.36 5.38e-21 Mean platelet volume; BRCA cis rs9399135 0.967 rs9376082 chr6:135346389 T/A cg24558204 chr6:135376177 HBS1L 0.44 12.09 0.43 1.94e-30 Red blood cell count; BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg02733842 chr7:1102375 C7orf50 -0.61 -11.57 -0.42 2.99e-28 Bronchopulmonary dysplasia; BRCA cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.54 -0.44 2.18e-32 Personality dimensions; BRCA cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg17158414 chr2:27665306 KRTCAP3 -0.31 -7.88 -0.3 1.38e-14 Total body bone mineral density; BRCA cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg07930192 chr7:1003750 NA 0.45 10.3 0.38 3.99e-23 Longevity;Endometriosis; BRCA cis rs10876993 0.890 rs4760165 chr12:58063801 C/T cg18357645 chr12:58087776 OS9 0.47 13.52 0.47 8.2e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs7818345 0.967 rs7004435 chr8:19282732 G/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.99 0.3 6.12e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg02297831 chr4:17616191 MED28 -0.36 -8.21 -0.31 1.24e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs701145 0.938 rs701143 chr3:154060047 A/G cg17054900 chr3:154042577 DHX36 0.67 11.69 0.42 9.13e-29 Coronary artery disease; BRCA cis rs9811920 0.695 rs793497 chr3:99505610 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -12.56 -0.45 1.63e-32 Axial length; BRCA cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg16414030 chr3:133502952 NA -0.54 -12.84 -0.45 9.98e-34 Iron status biomarkers; BRCA cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg17971929 chr21:40555470 PSMG1 0.77 18.0 0.58 6.76e-59 Cognitive function; BRCA cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg11764359 chr7:65958608 NA -0.64 -13.92 -0.48 1.22e-38 Aortic root size; BRCA cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg23018236 chr17:30244563 NA -0.66 -9.97 -0.37 7.61e-22 Hip circumference adjusted for BMI; BRCA cis rs10206020 0.921 rs9678719 chr2:1549628 A/G cg01028140 chr2:1542097 TPO -0.67 -14.19 -0.49 6e-40 IgG glycosylation; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg13047869 chr3:10149882 C3orf24 0.6 12.76 0.45 2.33e-33 Alzheimer's disease; BRCA cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg24558204 chr6:135376177 HBS1L 0.59 15.8 0.53 1.07e-47 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs2991971 0.810 rs2036021 chr1:45901370 G/A cg24296786 chr1:45957014 TESK2 0.57 13.26 0.46 1.3e-35 High light scatter reticulocyte count; BRCA cis rs7267979 1.000 rs2387881 chr20:25378172 A/G cg08601574 chr20:25228251 PYGB -0.37 -8.87 -0.33 7.33e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs897080 0.515 rs1067331 chr2:44627626 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.55 10.5 0.38 6.83e-24 Height; BRCA cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg11657440 chr19:46296263 DMWD -0.56 -13.35 -0.47 4.71e-36 Coronary artery disease; BRCA cis rs6580649 0.825 rs4760611 chr12:48421449 A/G cg24011408 chr12:48396354 COL2A1 0.48 7.96 0.3 8e-15 Lung cancer; BRCA trans rs2204008 0.775 rs11182513 chr12:38560252 G/C cg06521331 chr12:34319734 NA -0.5 -9.12 -0.34 9.82e-19 Bladder cancer; BRCA cis rs9858542 0.953 rs34588335 chr3:49407660 G/C cg03060546 chr3:49711283 APEH -0.51 -10.46 -0.38 9.45e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7552404 1.000 rs942270 chr1:76177332 G/A cg10523679 chr1:76189770 ACADM 0.75 15.27 0.52 4.39e-45 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.75 0.42 5.51e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7072216 0.763 rs3814142 chr10:100171104 C/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.45 0.47 1.78e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6942756 0.806 rs2718115 chr7:128871532 A/G cg02491457 chr7:128862824 NA 0.59 12.91 0.45 4.84e-34 White matter hyperintensity burden; BRCA cis rs68170813 0.559 rs7809508 chr7:107004119 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.82 -0.33 1.04e-17 Coronary artery disease; BRCA cis rs586533 0.801 rs605005 chr11:99499485 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.07 0.3 3.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs798554 0.704 rs798512 chr7:2782592 C/G cg19717773 chr7:2847554 GNA12 -0.43 -9.3 -0.35 2.18e-19 Height; BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg12016809 chr21:47604291 C21orf56 0.39 7.86 0.3 1.64e-14 Testicular germ cell tumor; BRCA trans rs36096196 0.891 rs74046969 chr1:2251348 G/A cg18313694 chr15:45480185 SHF 0.45 8.59 0.32 6.58e-17 Coronary artery disease; BRCA cis rs17539620 0.624 rs62432737 chr6:154834772 G/A cg20019720 chr6:154832845 CNKSR3 0.53 10.45 0.38 1.04e-23 Lipoprotein (a) levels; BRCA cis rs6964587 0.773 rs13223564 chr7:91932666 A/G cg01689657 chr7:91764605 CYP51A1 0.23 7.99 0.3 6.34e-15 Breast cancer; BRCA cis rs17601876 0.545 rs17523270 chr15:51538280 A/C cg19946085 chr15:51559439 CYP19A1 0.3 8.19 0.31 1.4e-15 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs11098499 0.863 rs3822195 chr4:120471660 C/T cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs367943 0.966 rs444322 chr5:112815399 C/T cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs7818345 1.000 rs13278459 chr8:19297583 A/G cg11303988 chr8:19266685 CSGALNACT1 0.31 7.94 0.3 8.83e-15 Language performance in older adults (adjusted for episodic memory); BRCA trans rs12517041 0.935 rs1835047 chr5:23296627 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.44 -8.1 -0.31 2.75e-15 Calcium levels; BRCA cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg16850897 chr7:100343110 ZAN 0.38 8.56 0.32 8.64e-17 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.51 0.32 1.23e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs738321 0.723 rs9622726 chr22:38506688 A/G cg20207973 chr22:38506712 BAIAP2L2 0.47 12.05 0.43 2.76e-30 Breast cancer; BRCA cis rs2882667 0.690 rs495638 chr5:138200942 C/T cg04439458 chr5:138467593 SIL1 0.31 7.97 0.3 7.3e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4908760 0.965 rs10864356 chr1:8569871 A/T cg20416874 chr1:8611966 RERE -0.28 -8.22 -0.31 1.12e-15 Vitiligo; BRCA cis rs2637266 0.935 rs2579728 chr10:78395598 A/G cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg10560079 chr2:191398806 TMEM194B 0.36 8.2 0.31 1.31e-15 Pulse pressure; BRCA cis rs3820928 0.904 rs4129884 chr2:227820943 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.75 -0.33 1.9e-17 Pulmonary function; BRCA cis rs11122272 0.735 rs2572254 chr1:231512593 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -12.33 -0.44 1.8e-31 Hemoglobin concentration; BRCA cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs10206020 0.921 rs72776300 chr2:1571152 A/G cg12573674 chr2:1569213 NA -0.64 -14.48 -0.5 2.8e-41 IgG glycosylation; BRCA cis rs7178572 0.568 rs11636554 chr15:77608747 C/T cg22256960 chr15:77711686 NA -0.39 -8.65 -0.32 4e-17 Type 2 diabetes; BRCA cis rs7756236 0.521 rs9462208 chr6:36627890 T/C cg08179530 chr6:36648295 CDKN1A 0.37 7.95 0.3 8.55e-15 QRS duration; BRCA cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg03709012 chr19:19516395 GATAD2A 0.73 16.16 0.54 1.74e-49 Tonsillectomy; BRCA trans rs877282 0.945 rs71491311 chr10:791747 G/A cg22713356 chr15:30763199 NA 1.41 28.53 0.75 4.39e-116 Uric acid levels; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg09177884 chr7:1199841 ZFAND2A -0.61 -15.06 -0.51 4.35e-44 Longevity;Endometriosis; BRCA cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.5 -10.07 -0.37 3.07e-22 Tonsillectomy; BRCA cis rs7572733 0.534 rs700684 chr2:198713099 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.18 0.37 1.14e-22 Dermatomyositis; BRCA cis rs68170813 0.559 rs17428071 chr7:106878200 C/G cg02696742 chr7:106810147 HBP1 -0.52 -8.45 -0.32 1.97e-16 Coronary artery disease; BRCA cis rs9814567 1.000 rs62271515 chr3:134300507 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9837602 1.000 rs35844878 chr3:99796626 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.13 0.4 1.97e-26 Breast cancer; BRCA cis rs11690935 0.885 rs6727017 chr2:172766847 T/A cg13550731 chr2:172543902 DYNC1I2 -0.81 -23.88 -0.69 1.38e-90 Schizophrenia; BRCA cis rs1003719 0.788 rs2835592 chr21:38464387 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg02734326 chr4:10020555 SLC2A9 0.39 8.46 0.32 1.78e-16 Bone mineral density; BRCA cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg03433033 chr1:76189801 ACADM 0.76 17.24 0.56 5.59e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12612619 0.704 rs11680633 chr2:27224209 T/C cg00617064 chr2:27272375 NA -0.31 -7.95 -0.3 8.68e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg24699146 chr1:24152579 HMGCL 0.3 8.11 0.31 2.64e-15 Immature fraction of reticulocytes; BRCA cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg17724175 chr1:150552817 MCL1 0.25 8.19 0.31 1.45e-15 Tonsillectomy; BRCA cis rs10227331 0.585 rs10240671 chr7:157298637 G/T cg04156418 chr7:157293606 NA -0.32 -9.14 -0.34 8.33e-19 Inattentive symptoms; BRCA cis rs6840360 0.615 rs1877188 chr4:152607931 T/C cg22705602 chr4:152727874 NA -0.38 -10.2 -0.37 9.45e-23 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg03354898 chr7:1950403 MAD1L1 -0.48 -9.95 -0.37 9.05e-22 Bipolar disorder and schizophrenia; BRCA cis rs7727544 0.584 rs7714191 chr5:131341541 C/G cg14196790 chr5:131705035 SLC22A5 0.32 8.1 0.31 2.75e-15 Blood metabolite levels; BRCA cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg07636037 chr3:49044803 WDR6 0.55 8.7 0.33 2.75e-17 Menarche (age at onset); BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 18.37 0.59 7.7e-61 Platelet count; BRCA cis rs870825 0.616 rs10022818 chr4:185619282 A/G cg04058563 chr4:185651563 MLF1IP 0.76 17.0 0.56 1e-53 Blood protein levels; BRCA cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs6540559 1.000 rs2235372 chr1:209960436 A/G cg25204440 chr1:209979598 IRF6 -0.41 -8.27 -0.31 7.61e-16 Cleft lip with or without cleft palate; BRCA cis rs8014204 0.901 rs2080087 chr14:75365062 C/T cg06637938 chr14:75390232 RPS6KL1 0.59 12.28 0.44 2.89e-31 Caffeine consumption; BRCA cis rs2652834 0.851 rs11071721 chr15:63350218 T/C cg05507819 chr15:63340323 TPM1 0.52 9.06 0.34 1.63e-18 HDL cholesterol; BRCA cis rs9325144 0.872 rs11183390 chr12:38729942 G/T cg26384229 chr12:38710491 ALG10B -0.41 -9.65 -0.36 1.13e-20 Morning vs. evening chronotype; BRCA trans rs629535 0.862 rs638412 chr8:70047690 C/T cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs11229555 0.645 rs36002376 chr11:58204809 C/G cg15696309 chr11:58395628 NA -0.52 -10.83 -0.39 3.19e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs4819388 0.793 rs4818887 chr21:45644950 C/T cg17383793 chr5:52405638 MOCS2 -0.46 -10.32 -0.38 3.27e-23 Celiac disease; BRCA cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg06145435 chr7:1022769 CYP2W1 0.49 9.02 0.34 2.23e-18 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg05564831 chr3:52568323 NT5DC2 0.34 7.99 0.3 6.31e-15 Electroencephalogram traits; BRCA cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.47 10.62 0.39 2.17e-24 Aortic root size; BRCA cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg09184832 chr6:79620586 NA -0.53 -11.53 -0.42 4.46e-28 Intelligence (multi-trait analysis); BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg20224285 chr3:52813920 ITIH1 0.32 8.12 0.31 2.37e-15 Cognitive function; BRCA cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg13628971 chr7:2884303 GNA12 0.39 8.74 0.33 2.01e-17 Height; BRCA cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg06484146 chr7:12443880 VWDE -0.76 -10.68 -0.39 1.29e-24 Coronary artery disease; BRCA cis rs11105306 1 rs11105306 chr12:89897388 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.54 -0.35 2.92e-20 NT-proBNP levels in acute coronary syndrome; BRCA cis rs57590327 0.555 rs13084107 chr3:81833577 T/C cg07356753 chr3:81810745 GBE1 -0.48 -11.17 -0.4 1.41e-26 Extraversion; BRCA cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4713118 0.662 rs9380046 chr6:28030499 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg16339924 chr4:17578868 LAP3 0.63 15.92 0.53 2.55e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7312933 0.703 rs10880259 chr12:42558003 T/C cg17420585 chr12:42539391 GXYLT1 -0.38 -8.08 -0.3 3.18e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.63e-18 Alzheimer's disease (late onset); BRCA cis rs9400271 0.632 rs9374069 chr6:109586334 A/G cg01475377 chr6:109611718 NA -0.44 -10.53 -0.38 5.13e-24 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg08392591 chr16:89556376 ANKRD11 0.55 13.89 0.48 1.6e-38 Multiple myeloma (IgH translocation); BRCA cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg20573242 chr4:122745356 CCNA2 0.47 10.58 0.39 3.3e-24 Type 2 diabetes; BRCA cis rs16976116 0.803 rs7168737 chr15:55501344 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2742234 0.590 rs2565201 chr10:43618484 T/C cg15436174 chr10:43711423 RASGEF1A -0.53 -10.56 -0.39 3.73e-24 Hirschsprung disease; BRCA cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg12292205 chr6:26970375 C6orf41 -0.47 -7.88 -0.3 1.43e-14 Intelligence (multi-trait analysis); BRCA cis rs332507 0.830 rs12631364 chr3:124405042 A/T cg05980111 chr3:124395277 KALRN 0.37 8.65 0.32 4.31e-17 Plateletcrit; BRCA cis rs4595586 0.505 rs76485055 chr12:39358294 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.54e-19 Morning vs. evening chronotype; BRCA cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg16339924 chr4:17578868 LAP3 0.59 14.38 0.49 8.36e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.61 12.93 0.46 3.78e-34 Lymphocyte counts; BRCA trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.97 -0.37 7.34e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.89e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs16854884 0.586 rs7642551 chr3:143732167 C/T cg06585982 chr3:143692056 C3orf58 0.47 9.83 0.36 2.48e-21 Economic and political preferences (feminism/equality); BRCA cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg21535247 chr6:8435926 SLC35B3 0.41 9.45 0.35 6.39e-20 Motion sickness; BRCA cis rs11583043 0.958 rs12730160 chr1:101438791 G/A cg16556008 chr1:101360663 SLC30A7;EXTL2 0.36 7.87 0.3 1.49e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs4803468 1.000 rs2288871 chr19:41917868 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -25.54 -0.71 1.07e-99 Height; BRCA cis rs4280164 0.945 rs4981503 chr14:24786293 T/G cg16194253 chr14:24768981 DHRS1;C14orf21 0.46 7.94 0.3 8.85e-15 Parent of origin effect on language impairment (paternal); BRCA cis rs7819412 0.749 rs11991118 chr8:10939273 A/C cg21775007 chr8:11205619 TDH 0.42 8.57 0.32 8.01e-17 Triglycerides; BRCA cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg23711669 chr6:146136114 FBXO30 -0.78 -18.66 -0.59 2.36e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs1468333 1.000 rs17171772 chr5:137514853 A/G cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.31 0.35 1.96e-19 Resting heart rate; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg22907277 chr7:1156413 C7orf50 0.38 8.59 0.32 6.84e-17 Longevity;Endometriosis; BRCA cis rs7809950 0.678 rs7777950 chr7:107004672 T/C cg23024343 chr7:107201750 COG5 -0.47 -9.61 -0.36 1.7e-20 Coronary artery disease; BRCA cis rs2882667 0.690 rs2351463 chr5:138258802 A/C cg04439458 chr5:138467593 SIL1 -0.32 -8.08 -0.3 3.35e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs72781680 0.665 rs72788298 chr2:24104293 T/C cg08917208 chr2:24149416 ATAD2B 0.61 10.44 0.38 1.18e-23 Lymphocyte counts; BRCA cis rs6577655 0.517 rs6998749 chr8:135584316 A/G cg17885191 chr8:135476712 NA -0.53 -8.99 -0.34 2.8e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs2011503 0.782 rs35545554 chr19:19715613 A/G cg15839431 chr19:19639596 YJEFN3 0.38 8.31 0.31 5.55e-16 Bipolar disorder; BRCA cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg08048268 chr3:133502702 NA 0.31 8.1 0.31 2.81e-15 Iron status biomarkers; BRCA cis rs1348850 0.789 rs2197611 chr2:178369036 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 9.62 0.36 1.51e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.96 0.4 1.01e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg05347473 chr6:146136440 FBXO30 0.43 8.51 0.32 1.27e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs757081 0.606 rs679201 chr11:17200891 T/C cg15432903 chr11:17409602 KCNJ11 -0.46 -8.67 -0.32 3.54e-17 Systolic blood pressure; BRCA cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg23796481 chr11:64053134 BAD;GPR137 0.51 10.59 0.39 3.04e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.9 -0.33 5.94e-18 Schizophrenia; BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg03923535 chr7:1197113 ZFAND2A 0.4 8.06 0.3 3.65e-15 Longevity;Endometriosis; BRCA cis rs722599 0.748 rs17093914 chr14:75363641 A/G cg08847533 chr14:75593920 NEK9 0.42 7.85 0.3 1.74e-14 IgG glycosylation; BRCA cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.35 0.47 4.95e-36 Mean platelet volume; BRCA cis rs11098499 0.570 rs6832740 chr4:120546136 T/C cg09307838 chr4:120376055 NA 0.59 12.12 0.43 1.43e-30 Corneal astigmatism; BRCA cis rs68170813 0.559 rs78404515 chr7:106909126 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.61 -0.32 5.62e-17 Coronary artery disease; BRCA cis rs7246657 0.722 rs4802051 chr19:38072328 C/A cg23950597 chr19:37808831 NA -0.51 -8.69 -0.33 3e-17 Coronary artery calcification; BRCA trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg03929089 chr4:120376271 NA 0.54 9.13 0.34 9.23e-19 Axial length; BRCA trans rs6582630 0.593 rs7134006 chr12:38596245 A/C cg06521331 chr12:34319734 NA -0.43 -8.1 -0.31 2.79e-15 Drug-induced liver injury (flucloxacillin); BRCA cis rs3820928 0.874 rs1320407 chr2:227867385 G/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.28 -0.31 7.12e-16 Pulmonary function; BRCA cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -9.39 -0.35 1.06e-19 Personality dimensions; BRCA cis rs3733585 0.746 rs4318650 chr4:10016868 T/C cg02734326 chr4:10020555 SLC2A9 0.36 7.86 0.3 1.59e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg09658497 chr7:2847517 GNA12 -0.4 -8.6 -0.32 6.26e-17 Height; BRCA cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg18357645 chr12:58087776 OS9 -0.33 -7.99 -0.3 6.21e-15 Multiple sclerosis; BRCA cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg24642439 chr20:33292090 TP53INP2 -0.44 -9.12 -0.34 9.85e-19 Glomerular filtration rate (creatinine); BRCA cis rs7520050 0.966 rs785464 chr1:46523089 T/C cg24296786 chr1:45957014 TESK2 0.41 9.26 0.34 3.13e-19 Red blood cell count;Reticulocyte count; BRCA cis rs4363385 0.667 rs454186 chr1:153049149 C/T cg25856811 chr1:152973957 SPRR3 -0.31 -8.01 -0.3 5.59e-15 Inflammatory skin disease; BRCA cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.38 -8.36 -0.31 3.85e-16 Educational attainment; BRCA cis rs4268898 1.000 rs6707781 chr2:24441883 T/G cg06627628 chr2:24431161 ITSN2 0.5 10.43 0.38 1.31e-23 Asthma; BRCA cis rs7772486 0.790 rs2253307 chr6:146196181 T/G cg23711669 chr6:146136114 FBXO30 0.79 18.99 0.6 4.44e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs4466137 0.953 rs974023 chr5:83014848 T/C cg16102102 chr5:83017553 HAPLN1 -0.92 -18.51 -0.59 1.38e-61 Prostate cancer; BRCA cis rs2832077 0.943 rs2832084 chr21:30154798 A/G cg24692254 chr21:30365293 RNF160 -0.48 -8.43 -0.32 2.31e-16 Cognitive test performance; BRCA trans rs7647973 0.626 rs1491985 chr3:49739507 G/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -8.52 -0.32 1.17e-16 Menarche (age at onset); BRCA cis rs10883723 0.810 rs7090034 chr10:104281155 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.03 0.62 1.31e-69 Allergic disease (asthma, hay fever or eczema); BRCA trans rs800082 0.698 rs1178943 chr3:144391772 T/G cg24215973 chr2:240111563 HDAC4 -0.65 -14.88 -0.51 3.18e-43 Smoking behavior; BRCA cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg26677194 chr12:130822605 PIWIL1 0.59 14.01 0.48 4.4e-39 Menopause (age at onset); BRCA cis rs6430585 0.591 rs12477421 chr2:136433740 A/G cg07169764 chr2:136633963 MCM6 1.14 22.15 0.66 4.46e-81 Corneal structure; BRCA cis rs7666738 0.830 rs28451001 chr4:98924544 T/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg02733842 chr7:1102375 C7orf50 -0.71 -12.62 -0.45 9.66e-33 Bronchopulmonary dysplasia; BRCA cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg22105103 chr4:187893119 NA 0.38 11.66 0.42 1.23e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.09 0.34 1.2e-18 Platelet count; BRCA cis rs72772090 0.539 rs11750671 chr5:96188482 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -11.05 -0.4 4.42e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs3780486 0.505 rs10217267 chr9:33146528 T/C cg04842962 chr6:43655489 MRPS18A 0.84 21.75 0.65 6.05e-79 IgG glycosylation; BRCA cis rs2425143 0.915 rs74355238 chr20:34441541 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.87 -0.33 7.09e-18 Blood protein levels; BRCA cis rs4363385 0.818 rs1415966 chr1:153002864 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.83e-16 Inflammatory skin disease; BRCA cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg00684032 chr4:1343700 KIAA1530 0.34 8.11 0.31 2.52e-15 Obesity-related traits; BRCA trans rs9291683 0.552 rs10939655 chr4:10014642 A/T cg26043149 chr18:55253948 FECH 0.39 8.34 0.31 4.61e-16 Bone mineral density; BRCA cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg21573476 chr21:45109991 RRP1B 0.49 12.56 0.45 1.66e-32 Mean corpuscular volume; BRCA cis rs73198271 0.740 rs10092720 chr8:8649117 A/C cg06636001 chr8:8085503 FLJ10661 -0.42 -8.04 -0.3 4.39e-15 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg26913058 chr16:419975 MRPL28 -0.43 -10.33 -0.38 2.99e-23 Bone mineral density (spine);Bone mineral density; BRCA cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs11031096 0.782 rs2284450 chr11:4149214 A/T cg18678763 chr11:4115507 RRM1 -0.38 -8.58 -0.32 7.24e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9790314 0.637 rs778649 chr3:160709377 C/T cg03342759 chr3:160939853 NMD3 -0.47 -8.84 -0.33 9.1e-18 Morning vs. evening chronotype; BRCA trans rs11098499 0.863 rs13140409 chr4:120503460 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.45 0.32 1.97e-16 Corneal astigmatism; BRCA cis rs514406 0.708 rs514881 chr1:53336737 A/G cg25767906 chr1:53392781 SCP2 0.46 10.39 0.38 1.87e-23 Monocyte count; BRCA cis rs6450176 0.638 rs3822497 chr5:53299693 C/G ch.5.1024479R chr5:53302184 ARL15 -0.88 -17.71 -0.57 2.03e-57 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg03146154 chr1:46216737 IPP 0.44 9.75 0.36 4.88e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3733585 0.673 rs4314284 chr4:9956096 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.52 -0.38 5.78e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.07 -0.3 3.45e-15 Total body bone mineral density; BRCA cis rs698813 0.637 rs4952706 chr2:44500536 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 8.86 0.33 8.06e-18 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs67460515 0.563 rs6441362 chr3:160877613 G/A cg03342759 chr3:160939853 NMD3 -0.69 -14.42 -0.5 5.41e-41 Parkinson's disease; BRCA cis rs35146811 0.735 rs1043915 chr7:99799845 T/A cg13334819 chr7:99746414 C7orf59 -0.34 -8.01 -0.3 5.46e-15 Coronary artery disease; BRCA cis rs9790314 0.540 rs35462273 chr3:160991877 C/T cg04691961 chr3:161091175 C3orf57 -0.37 -7.93 -0.3 9.49e-15 Morning vs. evening chronotype; BRCA cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs17818399 0.888 rs2346419 chr2:46845069 G/C cg02822958 chr2:46747628 ATP6V1E2 0.48 9.36 0.35 1.3e-19 Height; BRCA cis rs13217239 0.572 rs9379958 chr6:27066163 A/C cg12292205 chr6:26970375 C6orf41 -0.57 -12.7 -0.45 4.09e-33 Schizophrenia; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg04025307 chr7:1156635 C7orf50 0.7 18.01 0.58 6.12e-59 Longevity;Endometriosis; BRCA cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 14.57 0.5 9.62e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 0.663 rs10408619 chr19:38070474 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.15 0.34 7.72e-19 Coronary artery calcification; BRCA cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg02574844 chr11:5959923 NA -0.41 -8.11 -0.31 2.63e-15 DNA methylation (variation); BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs7255436 0.931 rs7249520 chr19:8446056 G/A cg10811474 chr19:8428787 ANGPTL4 -0.32 -8.05 -0.3 4.15e-15 HDL cholesterol; BRCA cis rs8180040 0.627 rs9821119 chr3:47198437 C/G cg16586182 chr3:47516702 SCAP -0.56 -12.49 -0.44 3.39e-32 Colorectal cancer; BRCA cis rs6912958 0.935 rs6454629 chr6:88165515 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -9.17 -0.34 6.33e-19 Monocyte percentage of white cells; BRCA cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg22455342 chr2:225449267 CUL3 0.65 17.12 0.56 2.37e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs490234 0.676 rs12202 chr9:128200299 C/G cg14078157 chr9:128172775 NA -0.42 -9.26 -0.34 3.02e-19 Mean arterial pressure; BRCA cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg21385522 chr1:16154831 NA 0.46 9.8 0.36 3.14e-21 Systolic blood pressure; BRCA cis rs9733 0.818 rs4970924 chr1:150633079 A/G cg13175981 chr1:150552382 MCL1 0.47 10.5 0.38 6.92e-24 Tonsillectomy; BRCA cis rs1577917 0.629 rs7761762 chr6:86205968 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.42 12.03 0.43 3.34e-30 Response to antipsychotic treatment; BRCA cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg11266682 chr4:10021025 SLC2A9 -0.43 -11.09 -0.4 2.95e-26 Bone mineral density; BRCA cis rs9283706 0.594 rs10515036 chr5:66343787 A/G cg11590213 chr5:66331682 MAST4 -0.38 -7.87 -0.3 1.56e-14 Coronary artery disease; BRCA cis rs7044106 0.708 rs1324472 chr9:123375110 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.5 9.83 0.36 2.58e-21 Hip circumference adjusted for BMI; BRCA cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.58e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs495337 0.760 rs6125813 chr20:48541183 G/T cg17835207 chr20:48524531 SPATA2 -0.7 -17.42 -0.57 6.46e-56 Psoriasis; BRCA cis rs1005277 0.579 rs1548255 chr10:38417193 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.69e-52 Extrinsic epigenetic age acceleration; BRCA cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg15212455 chr7:39170539 POU6F2 0.42 9.62 0.36 1.44e-20 IgG glycosylation; BRCA cis rs17376456 1.000 rs10514382 chr5:93566534 G/A cg25358565 chr5:93447407 FAM172A 1.26 19.33 0.61 6.88e-66 Diabetic retinopathy; BRCA cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg22906224 chr7:99728672 NA 0.42 8.16 0.31 1.84e-15 Coronary artery disease; BRCA cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.59 12.82 0.45 1.2e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7633857 0.532 rs9873705 chr3:160768818 A/T cg03342759 chr3:160939853 NMD3 -0.58 -12.22 -0.44 5.13e-31 Educational attainment (years of education); BRCA cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg23711669 chr6:146136114 FBXO30 0.75 17.41 0.57 7.7e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 1.000 rs73008453 chr6:163013384 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.15e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs34779708 0.931 rs4934720 chr10:35376800 T/C cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7772486 0.686 rs9399564 chr6:146078907 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -17.3 -0.56 2.68e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.954 rs7687843 chr4:120421211 C/T cg09307838 chr4:120376055 NA 0.72 15.24 0.52 5.6e-45 Corneal astigmatism; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.5 10.27 0.38 5.14e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg20203395 chr5:56204925 C5orf35 -0.49 -10.13 -0.37 1.87e-22 Initial pursuit acceleration; BRCA cis rs853679 0.517 rs4713152 chr6:28137454 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs9486719 1.000 rs11152959 chr6:96900272 C/T cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.66e-34 Migraine;Coronary artery disease; BRCA cis rs67981189 0.593 rs12896829 chr14:71463676 G/C cg15816911 chr14:71606274 NA 0.36 8.31 0.31 5.6e-16 Schizophrenia; BRCA trans rs7786808 0.712 rs2335167 chr7:158213948 A/C cg02030672 chr11:45687055 CHST1 0.5 11.26 0.41 6.19e-27 Obesity-related traits; BRCA cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs597539 0.652 rs482172 chr11:68668437 C/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 18.8 0.6 4.08e-63 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg05283184 chr6:79620031 NA -0.38 -9.58 -0.35 2.13e-20 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.5 0.59 1.72e-61 Cognitive function; BRCA cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg14092988 chr3:52407081 DNAH1 0.36 8.3 0.31 6e-16 Bipolar disorder; BRCA cis rs709400 0.628 rs12889639 chr14:103860206 G/A cg26031613 chr14:104095156 KLC1 -0.65 -14.22 -0.49 4.46e-40 Body mass index; BRCA cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg24642439 chr20:33292090 TP53INP2 0.4 7.87 0.3 1.52e-14 Height; BRCA cis rs11711311 0.955 rs1048892 chr3:113464859 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.24 0.41 7.45e-27 IgG glycosylation; BRCA cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg04025307 chr7:1156635 C7orf50 0.42 9.23 0.34 3.79e-19 Bronchopulmonary dysplasia; BRCA cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.88 0.62 8.13e-69 Platelet count; BRCA cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.27 -0.38 5.26e-23 Heart rate; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg05221455 chr11:829616 EFCAB4A -0.37 -8.23 -0.31 1.03e-15 Mean platelet volume; BRCA cis rs250677 0.559 rs17109198 chr5:148369712 C/T cg18129178 chr5:148520854 ABLIM3 -0.55 -10.42 -0.38 1.4e-23 Breast cancer; BRCA cis rs2115630 1.000 rs8037423 chr15:85355494 C/T cg11189052 chr15:85197271 WDR73 -0.36 -8.62 -0.32 5.18e-17 P wave terminal force; BRCA cis rs7474896 0.583 rs34185758 chr10:37990854 T/C cg25427524 chr10:38739819 LOC399744 -0.55 -9.4 -0.35 9.76e-20 Obesity (extreme); BRCA trans rs11039798 0.588 rs11039781 chr11:48523085 T/G cg03929089 chr4:120376271 NA 0.5 8.3 0.31 6.17e-16 Axial length; BRCA cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg07606381 chr6:8435919 SLC35B3 0.64 14.18 0.49 7.18e-40 Motion sickness; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg16425592 chr11:842748 TSPAN4;POLR2L -0.67 -15.14 -0.51 1.83e-44 Mean platelet volume; BRCA cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg11764359 chr7:65958608 NA 0.8 19.49 0.61 9.4e-67 Aortic root size; BRCA cis rs9467773 0.620 rs2130657 chr6:26650826 C/T cg11502198 chr6:26597334 ABT1 0.56 11.97 0.43 6.47e-30 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs11051970 0.636 rs1128591 chr12:32569351 T/C cg24626660 chr12:32551988 NA 0.31 9.1 0.34 1.1e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs875971 0.789 rs28815324 chr7:65565776 A/T cg11764359 chr7:65958608 NA -0.63 -11.14 -0.4 1.77e-26 Aortic root size; BRCA cis rs2991971 1.000 rs606542 chr1:46013933 T/C cg24296786 chr1:45957014 TESK2 0.6 14.53 0.5 1.52e-41 High light scatter reticulocyte count; BRCA cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg03146154 chr1:46216737 IPP 0.48 10.46 0.38 9.27e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs61931739 0.500 rs11053242 chr12:34511625 A/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.26e-22 Morning vs. evening chronotype; BRCA cis rs220324 0.688 rs9975332 chr21:43559902 C/T cg09727148 chr21:43560719 UMODL1 -0.53 -9.64 -0.36 1.26e-20 Idiopathic osteonecrosis of the femoral head; BRCA cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.41 -7.84 -0.3 1.96e-14 Height; BRCA cis rs7520050 0.751 rs592214 chr1:46024505 G/A cg24296786 chr1:45957014 TESK2 0.48 10.88 0.4 2.16e-25 Red blood cell count;Reticulocyte count; BRCA cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg27478167 chr7:817139 HEATR2 -0.42 -8.98 -0.33 2.94e-18 Cerebrospinal P-tau181p levels; BRCA cis rs9359856 0.564 rs72913976 chr6:90390233 T/C cg13799429 chr6:90582589 CASP8AP2 -0.67 -8.57 -0.32 7.79e-17 Bipolar disorder; BRCA cis rs4642101 0.597 rs9839768 chr3:12821403 C/T cg24848339 chr3:12840334 CAND2 0.49 13.14 0.46 4.54e-35 QRS complex (12-leadsum); BRCA cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg14558114 chr2:88469736 THNSL2 0.59 8.36 0.31 3.96e-16 Plasma clusterin levels; BRCA cis rs796364 0.760 rs74993507 chr2:201068684 C/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.61 -8.89 -0.33 6.3e-18 Schizophrenia; BRCA cis rs1005277 0.541 rs1740741 chr10:38515334 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.15 -0.58 1.17e-59 Extrinsic epigenetic age acceleration; BRCA cis rs6089584 1.000 rs3787424 chr20:60559219 G/A cg06108461 chr20:60628389 TAF4 -0.8 -16.97 -0.56 1.34e-53 Body mass index; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg10729496 chr3:10149963 C3orf24 0.49 9.17 0.34 6.54e-19 Alzheimer's disease; BRCA cis rs7149337 0.933 rs28705789 chr14:51713508 C/T cg23942311 chr14:51606299 NA 0.35 9.47 0.35 5.32e-20 Cancer; BRCA cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg05347473 chr6:146136440 FBXO30 0.59 10.94 0.4 1.19e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs113835537 0.529 rs11227515 chr11:66287383 C/T cg24851651 chr11:66362959 CCS 0.42 8.02 0.3 5.18e-15 Airway imaging phenotypes; BRCA cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg13256891 chr4:100009986 ADH5 0.5 9.49 0.35 4.46e-20 Smoking initiation; BRCA cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg24549020 chr5:56110836 MAP3K1 0.55 11.19 0.4 1.12e-26 Initial pursuit acceleration; BRCA cis rs4268898 0.552 rs11125455 chr2:24374557 C/G cg26838691 chr2:24397539 C2orf84 0.39 7.92 0.3 1.03e-14 Asthma; BRCA cis rs600806 0.850 rs10858085 chr1:109914983 A/G cg20591472 chr1:110008990 SYPL2 0.32 7.94 0.3 9.24e-15 Intelligence (multi-trait analysis); BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg05863683 chr7:1912471 MAD1L1 0.36 8.19 0.31 1.41e-15 Schizophrenia; BRCA cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg26031613 chr14:104095156 KLC1 -0.54 -9.54 -0.35 2.95e-20 Reticulocyte count; BRCA cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.54 0.35 2.91e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg01579765 chr21:45077557 HSF2BP -0.41 -10.55 -0.39 4.16e-24 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg10556349 chr10:835070 NA 0.64 8.74 0.33 1.98e-17 Eosinophil percentage of granulocytes; BRCA cis rs11971779 0.527 rs4379397 chr7:139043385 G/A cg07862535 chr7:139043722 LUC7L2 0.38 10.37 0.38 2.13e-23 Diisocyanate-induced asthma; BRCA trans rs7647973 0.626 rs1078341 chr3:49685592 A/G cg21659725 chr3:3221576 CRBN -0.46 -8.68 -0.32 3.25e-17 Menarche (age at onset); BRCA cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg06552810 chr11:31128660 NA -0.39 -8.69 -0.33 3.06e-17 Red blood cell count; BRCA cis rs17253792 0.915 rs75862063 chr14:56177769 G/T cg01858014 chr14:56050164 KTN1 -0.67 -8.24 -0.31 9.82e-16 Putamen volume; BRCA trans rs8073060 0.586 rs4796104 chr17:34046832 T/C cg19694781 chr19:47549865 TMEM160 1.07 20.64 0.63 6.34e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs965469 1.000 rs2236108 chr20:3286331 A/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.2 -0.37 9.87e-23 IFN-related cytopenia; BRCA cis rs2742234 0.541 rs11238481 chr10:43719286 A/G cg15436174 chr10:43711423 RASGEF1A 0.53 10.6 0.39 2.8e-24 Hirschsprung disease; BRCA cis rs6834538 1.000 rs2171280 chr4:113472637 A/G cg05166686 chr4:113558556 LARP7;C4orf21 -0.39 -8.97 -0.33 3.33e-18 Free thyroxine concentration; BRCA cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.84 0.39 3.02e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6430585 0.536 rs3213892 chr2:136552517 G/A cg07169764 chr2:136633963 MCM6 1.27 30.26 0.77 1.84e-125 Corneal structure; BRCA cis rs7766436 0.767 rs6909752 chr6:22612629 G/A cg13666174 chr6:22585274 NA -0.36 -9.18 -0.34 6.07e-19 Coronary artery disease; BRCA cis rs7249921 0.833 rs73044054 chr19:35666661 C/A cg15419183 chr19:35660584 FXYD5 0.46 10.42 0.38 1.32e-23 Platelet count; BRCA cis rs877282 0.891 rs12767043 chr10:797943 C/T cg17470449 chr10:769945 NA 0.5 8.63 0.32 4.9e-17 Uric acid levels; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Menopause (age at onset); BRCA cis rs9287719 0.649 rs6730247 chr2:10725888 G/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA trans rs8062405 0.792 rs12446550 chr16:28543381 G/A cg09719594 chr16:21412588 NA -0.33 -7.96 -0.3 7.79e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6748734 0.817 rs10182575 chr2:241806690 C/T cg02820040 chr2:241836501 C2orf54 -0.46 -9.05 -0.34 1.76e-18 Urinary metabolites; BRCA cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.59 19.72 0.62 5.39e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10193935 0.901 rs13393459 chr2:42463124 C/T cg27598129 chr2:42591480 NA -0.97 -14.84 -0.51 5.2e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg15145296 chr3:125709740 NA -0.54 -9.49 -0.35 4.36e-20 Blood pressure (smoking interaction); BRCA cis rs1348850 0.914 rs2060929 chr2:178280031 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 9.04 0.34 1.83e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7677751 0.747 rs1800809 chr4:55093914 A/G cg17187183 chr4:55093834 PDGFRA 0.44 9.03 0.34 2.03e-18 Corneal astigmatism; BRCA cis rs62458065 0.513 rs787216 chr7:32578891 G/A cg20159608 chr7:32802032 NA -0.5 -9.64 -0.36 1.25e-20 Metabolite levels (HVA/MHPG ratio); BRCA cis rs2842992 0.724 rs4709368 chr6:160204127 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.59 -13.56 -0.47 5.28e-37 Age-related macular degeneration (geographic atrophy); BRCA cis rs6714710 0.580 rs57804205 chr2:98454472 G/A cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.86e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs651907 0.557 rs3864012 chr3:101397623 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 16.53 0.55 2.32e-51 Colorectal cancer; BRCA trans rs7786808 0.712 rs2335170 chr7:158207101 G/A cg02030672 chr11:45687055 CHST1 0.52 11.51 0.41 5.49e-28 Obesity-related traits; BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg14196790 chr5:131705035 SLC22A5 0.32 8.42 0.32 2.56e-16 Breast cancer; BRCA cis rs12493885 0.505 rs357489 chr3:153884517 A/T cg12800244 chr3:153838788 SGEF 0.45 9.17 0.34 6.37e-19 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7851660 0.506 rs1912996 chr9:100598261 G/T cg13688889 chr9:100608707 NA -0.49 -9.94 -0.37 9.38e-22 Strep throat; BRCA cis rs7264396 0.790 rs3787168 chr20:34233278 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.74 -15.83 -0.53 7.33e-48 Total cholesterol levels; BRCA cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg08885076 chr2:99613938 TSGA10 0.43 10.31 0.38 3.72e-23 Chronic sinus infection; BRCA cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg00074818 chr8:8560427 CLDN23 0.39 8.56 0.32 8.11e-17 Obesity-related traits; BRCA cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.45 0.32 2.02e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9287719 0.967 rs6744854 chr2:10747246 C/G cg00105475 chr2:10696890 NA 0.44 10.4 0.38 1.66e-23 Prostate cancer; BRCA cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.66 0.39 1.63e-24 Tonsillectomy; BRCA trans rs9467711 0.659 rs3734542 chr6:26468326 G/A cg01620082 chr3:125678407 NA -0.7 -8.74 -0.33 2e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs11586313 0.571 rs11583382 chr1:152874096 G/A cg07796016 chr1:152779584 LCE1C -0.4 -7.95 -0.3 8.58e-15 Vitamin D levels; BRCA trans rs35110281 0.805 rs2838318 chr21:44991825 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.26 0.31 8.23e-16 Mean corpuscular volume; BRCA cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg04455712 chr21:45112962 RRP1B 0.42 11.02 0.4 5.4e-26 Mean corpuscular volume; BRCA trans rs11976180 1.000 rs2961126 chr7:143762736 A/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs9486719 1.000 rs3798295 chr6:97052164 C/T cg06623918 chr6:96969491 KIAA0776 -0.76 -13.29 -0.47 8.99e-36 Migraine;Coronary artery disease; BRCA cis rs7707921 0.752 rs6882565 chr5:81356421 G/A cg15871215 chr5:81402204 ATG10 -0.36 -8.34 -0.31 4.48e-16 Breast cancer; BRCA trans rs61931739 0.553 rs68124042 chr12:34064431 C/A cg13010199 chr12:38710504 ALG10B 0.49 9.39 0.35 1.02e-19 Morning vs. evening chronotype; BRCA cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg02951883 chr7:2050386 MAD1L1 -0.49 -11.43 -0.41 1.14e-27 Schizophrenia; BRCA cis rs6964587 1.000 rs2299239 chr7:91654617 C/T cg17063962 chr7:91808500 NA 0.52 12.41 0.44 7.57e-32 Breast cancer; BRCA cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg08754478 chr10:133766260 PPP2R2D -0.69 -14.22 -0.49 4.63e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs10465746 0.747 rs1952066 chr1:84436456 T/C cg10977910 chr1:84465055 TTLL7 0.57 11.92 0.43 1.01e-29 Obesity-related traits; BRCA cis rs3784262 0.669 rs12914455 chr15:58312096 G/A cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.4 -0.38 1.67e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg11663144 chr21:46675770 NA -0.49 -9.81 -0.36 3.05e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg11890956 chr21:40555474 PSMG1 -0.61 -13.62 -0.47 2.86e-37 Menarche (age at onset); BRCA cis rs3099143 0.908 rs6495222 chr15:77180015 A/C cg21673338 chr15:77095150 SCAPER 0.52 9.44 0.35 6.69e-20 Recalcitrant atopic dermatitis; BRCA cis rs9790314 0.690 rs7614375 chr3:160851331 A/T cg03342759 chr3:160939853 NMD3 -0.54 -11.37 -0.41 2.03e-27 Morning vs. evening chronotype; BRCA cis rs7829975 0.582 rs6982832 chr8:8792217 A/C cg08975724 chr8:8085496 FLJ10661 -0.42 -8.85 -0.33 8.62e-18 Mood instability; BRCA cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg09065629 chr16:1709722 CRAMP1L 0.37 8.63 0.32 4.81e-17 Coronary artery disease; BRCA cis rs3784262 0.904 rs3784263 chr15:58253062 C/T cg12031962 chr15:58353849 ALDH1A2 -0.43 -11.73 -0.42 6.42e-29 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs1459104 0.925 rs34245100 chr11:55211191 G/A cg15704280 chr7:45808275 SEPT13 0.67 8.34 0.31 4.59e-16 Body mass index; BRCA cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg21918786 chr6:109611834 NA -0.48 -13.78 -0.48 5.02e-38 Reticulocyte fraction of red cells; BRCA cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg03146154 chr1:46216737 IPP 0.54 12.05 0.43 2.86e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2243480 1.000 rs316322 chr7:65611233 G/C cg18252515 chr7:66147081 NA -1.04 -15.47 -0.52 4.14e-46 Diabetic kidney disease; BRCA cis rs10883723 0.810 rs1056857 chr10:104240003 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.57 0.57 1.1e-56 Allergic disease (asthma, hay fever or eczema); BRCA trans rs9325144 0.555 rs7960411 chr12:38703019 A/G cg23762105 chr12:34175262 ALG10 0.36 8.31 0.31 5.78e-16 Morning vs. evening chronotype; BRCA cis rs1403694 0.669 rs10440056 chr3:186433822 C/T cg12454167 chr3:186435060 KNG1 0.29 7.92 0.3 1.04e-14 Blood protein levels; BRCA cis rs72781680 0.799 rs2712084 chr2:24003051 A/G cg08917208 chr2:24149416 ATAD2B 0.59 9.76 0.36 4.49e-21 Lymphocyte counts; BRCA cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg25554036 chr4:6271136 WFS1 0.43 10.0 0.37 5.77e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7523050 0.643 rs35860016 chr1:109404639 C/T cg08274380 chr1:109419600 GPSM2 0.98 14.02 0.49 3.82e-39 Fat distribution (HIV); BRCA cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg11663144 chr21:46675770 NA -0.61 -14.27 -0.49 2.52e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6963495 0.719 rs73190172 chr7:105161210 T/C cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg08219700 chr8:58056026 NA 0.54 8.78 0.33 1.44e-17 Developmental language disorder (linguistic errors); BRCA cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg03264133 chr6:25882463 NA -0.54 -11.42 -0.41 1.27e-27 Intelligence (multi-trait analysis); BRCA cis rs8077889 0.956 rs4793026 chr17:41850508 A/G cg26893861 chr17:41843967 DUSP3 0.65 12.81 0.45 1.35e-33 Triglycerides; BRCA cis rs2204008 0.540 rs1283306 chr12:38153778 C/A cg26384229 chr12:38710491 ALG10B -0.44 -10.05 -0.37 3.66e-22 Bladder cancer; BRCA cis rs12760731 0.720 rs7548163 chr1:178306695 G/A cg00404053 chr1:178313656 RASAL2 0.62 8.57 0.32 7.67e-17 Obesity-related traits; BRCA cis rs897984 0.806 rs1046276 chr16:30914626 A/G cg00531865 chr16:30841666 NA 0.38 9.15 0.34 7.41e-19 Dementia with Lewy bodies; BRCA cis rs896854 0.654 rs6982393 chr8:95980708 T/C cg13393036 chr8:95962371 TP53INP1 -0.3 -8.06 -0.3 3.68e-15 Type 2 diabetes; BRCA cis rs4563143 0.675 rs55884228 chr19:29243897 G/T cg12756686 chr19:29218302 NA 0.57 10.98 0.4 8.46e-26 Methadone dose in opioid dependence; BRCA cis rs6460942 1.000 rs75333414 chr7:12303829 T/A cg06484146 chr7:12443880 VWDE -0.55 -8.1 -0.31 2.72e-15 Coronary artery disease; BRCA cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.37 -8.25 -0.31 9.03e-16 Axial length; BRCA cis rs523522 0.962 rs651627 chr12:121009198 C/T cg27279351 chr12:120934652 DYNLL1 0.56 13.39 0.47 3.26e-36 High light scatter reticulocyte count; BRCA cis rs1401999 1.000 rs7620350 chr3:183710053 A/T cg01324343 chr3:183735012 ABCC5 0.83 21.19 0.64 6.89e-76 Anterior chamber depth; BRCA cis rs7044106 0.791 rs10984998 chr9:123481516 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 17.33 0.57 1.92e-55 Hip circumference adjusted for BMI; BRCA cis rs4919694 1.000 rs12258551 chr10:104767892 C/G cg04362960 chr10:104952993 NT5C2 0.94 14.64 0.5 4.47e-42 Arsenic metabolism; BRCA cis rs2594989 0.708 rs2594997 chr3:11365739 A/T cg01796438 chr3:11312864 ATG7 -0.55 -8.22 -0.31 1.16e-15 Circulating chemerin levels; BRCA cis rs10911251 0.528 rs4652777 chr1:183091992 T/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.08e-57 Colorectal cancer; BRCA cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.68 0.39 1.32e-24 IgG glycosylation; BRCA cis rs490234 0.586 rs12553548 chr9:128155261 T/G cg14078157 chr9:128172775 NA -0.34 -8.12 -0.31 2.41e-15 Mean arterial pressure; BRCA cis rs1801251 1.000 rs1044480 chr2:233633736 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.87 0.48 2.01e-38 Coronary artery disease; BRCA cis rs4363385 0.747 rs2075739 chr1:152975495 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs9287719 0.649 rs10803725 chr2:10732346 T/C cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs372883 0.564 rs766928 chr21:30753606 A/G cg08807101 chr21:30365312 RNF160 0.41 8.97 0.33 3.16e-18 Pancreatic cancer; BRCA cis rs10911363 0.659 rs2275676 chr1:183430822 C/G cg09173681 chr1:183549694 NCF2 -0.49 -10.49 -0.38 7.25e-24 Systemic lupus erythematosus; BRCA cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg21475434 chr5:93447410 FAM172A 0.69 8.72 0.33 2.43e-17 Diabetic retinopathy; BRCA cis rs9486715 0.867 rs9384628 chr6:96960232 T/C cg06623918 chr6:96969491 KIAA0776 0.89 25.79 0.71 4.53e-101 Headache; BRCA cis rs7172677 0.737 rs12914536 chr15:75437715 C/T cg14664628 chr15:75095509 CSK -0.36 -7.81 -0.3 2.34e-14 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7089973 0.604 rs765173 chr10:116601675 C/T cg23260525 chr10:116636907 FAM160B1 0.31 8.34 0.31 4.65e-16 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs7927771 0.524 rs10742820 chr11:47781057 C/T cg20307385 chr11:47447363 PSMC3 -0.41 -9.55 -0.35 2.8e-20 Subjective well-being; BRCA cis rs6460942 0.915 rs62448599 chr7:12453764 C/T cg20607287 chr7:12443886 VWDE -0.59 -8.47 -0.32 1.66e-16 Coronary artery disease; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg23708337 chr7:1209742 NA 0.47 9.06 0.34 1.55e-18 Longevity;Endometriosis; BRCA cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg02187348 chr16:89574699 SPG7 0.5 11.87 0.43 1.61e-29 Multiple myeloma (IgH translocation); BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 19.65 0.61 1.3e-67 Platelet count; BRCA cis rs9487051 0.743 rs388526 chr6:109543425 C/G cg01475377 chr6:109611718 NA -0.42 -9.79 -0.36 3.63e-21 Reticulocyte fraction of red cells; BRCA cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg22972055 chr7:872293 UNC84A 0.38 8.3 0.31 6.12e-16 Cerebrospinal P-tau181p levels; BRCA cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg20362242 chr5:692897 TPPP 0.54 8.72 0.33 2.42e-17 Lung disease severity in cystic fibrosis; BRCA cis rs8114671 0.836 rs4911461 chr20:33629993 A/C cg07148914 chr20:33460835 GGT7 -0.41 -8.96 -0.33 3.52e-18 Height; BRCA cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg18876405 chr7:65276391 NA 0.56 13.33 0.47 6.11e-36 Aortic root size; BRCA cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg26395211 chr5:140044315 WDR55 0.37 8.53 0.32 1.08e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs17376456 0.569 rs2045020 chr5:93224466 T/C cg25358565 chr5:93447407 FAM172A -0.68 -11.56 -0.42 3.23e-28 Diabetic retinopathy; BRCA cis rs9733 0.570 rs951281 chr1:150691122 A/C cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs738322 0.753 rs5756968 chr22:38595240 C/T cg25457927 chr22:38595422 NA 0.5 21.42 0.65 3.85e-77 Cutaneous nevi; BRCA trans rs1997103 0.954 rs4947505 chr7:55409448 T/C cg20935933 chr6:143382018 AIG1 0.61 11.73 0.42 6.24e-29 QRS interval (sulfonylurea treatment interaction); BRCA cis rs514406 0.708 rs546334 chr1:53326210 T/C cg01802117 chr1:53393560 SCP2 -0.4 -9.0 -0.34 2.55e-18 Monocyte count; BRCA cis rs6121246 0.908 rs17093657 chr20:30428894 G/A cg13852791 chr20:30311386 BCL2L1 0.79 15.28 0.52 3.74e-45 Mean corpuscular hemoglobin; BRCA cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.85 0.36 2.13e-21 Lung cancer in ever smokers; BRCA cis rs6582630 0.599 rs1589392 chr12:38418535 G/C cg26384229 chr12:38710491 ALG10B -0.43 -9.98 -0.37 6.52e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.89 -0.3 1.36e-14 Aortic root size; BRCA cis rs9290065 0.519 rs2376475 chr3:160708942 C/T cg03342759 chr3:160939853 NMD3 -0.5 -10.16 -0.37 1.36e-22 Kawasaki disease; BRCA cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg07636037 chr3:49044803 WDR6 0.94 27.28 0.73 2.99e-109 Parkinson's disease; BRCA cis rs10857712 0.687 rs11101742 chr10:135224372 C/G cg01444801 chr10:135216882 MTG1 -0.33 -8.32 -0.31 5.37e-16 Systemic lupus erythematosus; BRCA cis rs68170813 0.559 rs6971774 chr7:106834139 A/G cg02696742 chr7:106810147 HBP1 -0.51 -8.2 -0.31 1.28e-15 Coronary artery disease; BRCA trans rs208520 0.690 rs10455594 chr6:66737894 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.79 0.64 1.05e-73 Exhaled nitric oxide output; BRCA cis rs13394619 0.875 rs9287734 chr2:11724475 A/G cg07314298 chr2:11723111 GREB1 -0.55 -12.25 -0.44 3.74e-31 Endometriosis; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg22800045 chr5:56110881 MAP3K1 0.7 13.07 0.46 9.58e-35 Initial pursuit acceleration; BRCA cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg13628971 chr7:2884303 GNA12 0.53 12.04 0.43 3.12e-30 Height; BRCA cis rs72781680 1.000 rs56068891 chr2:24230633 A/G cg20701182 chr2:24300061 SF3B14 0.66 9.47 0.35 5.4e-20 Lymphocyte counts; BRCA cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.5e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg08392591 chr16:89556376 ANKRD11 0.49 11.77 0.42 4.26e-29 Multiple myeloma (IgH translocation); BRCA cis rs2991971 0.934 rs7903 chr1:45976472 G/C cg24296786 chr1:45957014 TESK2 0.64 15.79 0.53 1.16e-47 High light scatter reticulocyte count; BRCA cis rs2243480 1.000 rs67728539 chr7:65378124 G/A cg18252515 chr7:66147081 NA -0.79 -11.11 -0.4 2.35e-26 Diabetic kidney disease; BRCA cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.94 0.51 1.75e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7975161 0.630 rs7978101 chr12:104630510 A/G cg25273343 chr12:104657179 TXNRD1 -0.59 -9.88 -0.36 1.59e-21 Toenail selenium levels; BRCA trans rs35110281 0.837 rs7279958 chr21:45016016 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.49 0.32 1.41e-16 Mean corpuscular volume; BRCA cis rs365132 0.875 rs353479 chr5:176372593 C/T cg16309518 chr5:176445507 NA -0.39 -9.48 -0.35 4.82e-20 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2050392 0.517 rs687036 chr10:30761249 G/A cg18806716 chr10:30721971 MAP3K8 -0.42 -9.98 -0.37 6.6e-22 Inflammatory bowel disease; BRCA cis rs9287719 0.967 rs759402 chr2:10729554 A/T cg02196655 chr2:10830764 NOL10 -0.3 -8.09 -0.3 3.04e-15 Prostate cancer; BRCA cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg17366294 chr4:99064904 C4orf37 0.42 9.77 0.36 4.27e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg22875332 chr1:76189707 ACADM -0.53 -10.27 -0.38 5.49e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10985070 0.507 rs12551347 chr9:123936594 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.42 8.62 0.32 5.26e-17 Rheumatoid arthritis; BRCA cis rs11711311 0.712 rs6795099 chr3:113338782 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.38 -8.32 -0.31 5.42e-16 IgG glycosylation; BRCA cis rs7523050 0.643 rs7551142 chr1:109399710 G/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs2860975 0.875 rs2211272 chr10:96765905 G/A cg09036531 chr10:96991505 NA -0.38 -8.18 -0.31 1.5e-15 Immune response to smallpox vaccine (IL-6); BRCA cis rs17685 0.712 rs1859794 chr7:75821544 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.36 -0.31 3.89e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg08392591 chr16:89556376 ANKRD11 0.35 8.2 0.31 1.33e-15 Multiple myeloma (IgH translocation); BRCA cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg18964960 chr10:1102726 WDR37 0.65 8.71 0.33 2.69e-17 Eosinophil percentage of granulocytes; BRCA cis rs11711311 1.000 rs9288984 chr3:113525956 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.68 -0.39 1.35e-24 IgG glycosylation; BRCA cis rs68170813 0.559 rs76859341 chr7:107070146 C/G cg02696742 chr7:106810147 HBP1 -0.48 -8.04 -0.3 4.52e-15 Coronary artery disease; BRCA cis rs9527 0.590 rs11191544 chr10:104827198 C/G cg04362960 chr10:104952993 NT5C2 0.43 9.86 0.36 1.89e-21 Arsenic metabolism; BRCA cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg24829409 chr8:58192753 C8orf71 -0.45 -8.63 -0.32 5.04e-17 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs9998582 chr4:98938949 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7100689 0.646 rs1538823 chr10:82088040 C/A cg01528321 chr10:82214614 TSPAN14 0.81 17.21 0.56 8.09e-55 Post bronchodilator FEV1; BRCA cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg06138931 chr13:21896616 NA 0.56 10.52 0.38 5.72e-24 White matter hyperintensity burden; BRCA trans rs3741489 1.000 rs3741489 chr12:133417802 A/G cg24132527 chr5:140019269 TMCO6 1.08 12.68 0.45 5e-33 Cognitive function; BRCA cis rs7949030 0.626 rs11231141 chr11:62326265 T/C cg22862634 chr11:62369728 EML3;MTA2 0.55 13.56 0.47 5.59e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05903289 chr2:130345205 NA -0.33 -8.3 -0.31 6.3e-16 Response to cytidine analogues (gemcitabine); BRCA cis rs9304742 0.962 rs1808106 chr19:53452944 T/G cg24044776 chr19:53454761 ZNF816A -0.35 -7.86 -0.3 1.58e-14 Psoriasis; BRCA cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg24549020 chr5:56110836 MAP3K1 0.64 13.06 0.46 9.94e-35 Initial pursuit acceleration; BRCA cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg18876405 chr7:65276391 NA -0.63 -15.42 -0.52 7.67e-46 Aortic root size; BRCA cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.51 8.77 0.33 1.64e-17 Mean platelet volume; BRCA cis rs7927771 0.929 rs66749409 chr11:47568074 C/T cg18512352 chr11:47633146 NA -0.37 -9.1 -0.34 1.1e-18 Subjective well-being; BRCA cis rs4947534 1 rs4947534 chr7:56079094 T/C cg09872392 chr7:56161020 PHKG1 -0.41 -9.39 -0.35 1.02e-19 Amino acid levels;Blood metabolite levels; BRCA cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.05 -0.54 5.71e-49 Heart rate; BRCA cis rs2625529 0.938 rs4776579 chr15:72132608 C/T cg16672083 chr15:72433130 SENP8 -0.73 -16.4 -0.54 1e-50 Red blood cell count; BRCA cis rs11105298 0.891 rs1054807 chr12:89913419 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.6 -0.36 1.74e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs11098499 0.780 rs7692994 chr4:120427489 C/A cg25214090 chr10:38739885 LOC399744 0.46 10.53 0.38 4.99e-24 Corneal astigmatism; BRCA trans rs911555 0.755 rs11620897 chr14:103944861 T/G cg17675199 chr6:35436792 RPL10A 0.29 7.85 0.3 1.8e-14 Intelligence (multi-trait analysis); BRCA cis rs9818758 0.607 rs11706052 chr3:49064110 A/G cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7647973 0.667 rs9869256 chr3:49624095 T/G cg06212747 chr3:49208901 KLHDC8B 0.59 8.28 0.31 7.36e-16 Menarche (age at onset); BRCA cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.49e-52 Extrinsic epigenetic age acceleration; BRCA cis rs6570726 0.791 rs9373464 chr6:145907167 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -8.2 -0.31 1.36e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12667521 chr19:29218732 NA 0.47 8.76 0.33 1.79e-17 Methadone dose in opioid dependence; BRCA cis rs4908760 0.864 rs12136766 chr1:8663821 C/T cg20416874 chr1:8611966 RERE -0.27 -7.83 -0.3 2.09e-14 Vitiligo; BRCA cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg11890956 chr21:40555474 PSMG1 -0.85 -21.99 -0.66 3.23e-80 Cognitive function; BRCA cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg17366294 chr4:99064904 C4orf37 0.41 9.74 0.36 5.38e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg15691649 chr6:25882328 NA -0.43 -8.37 -0.31 3.7e-16 Uric acid levels; BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13126279 chr21:47581558 C21orf56 -0.5 -10.88 -0.4 2.15e-25 Testicular germ cell tumor; BRCA cis rs4423214 0.879 rs1630498 chr11:71150785 A/C cg05163923 chr11:71159392 DHCR7 -0.57 -11.67 -0.42 1.14e-28 Vitamin D levels; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg15242686 chr22:24348715 GSTTP1 0.38 9.36 0.35 1.37e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs910316 0.763 rs13712 chr14:75483812 T/C cg11812906 chr14:75593930 NEK9 0.67 15.72 0.53 2.55e-47 Height; BRCA trans rs11976180 1.000 rs6464574 chr7:143748257 G/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.53 -9.35 -0.35 1.45e-19 Obesity-related traits; BRCA trans rs1005277 0.522 rs289647 chr10:37968278 A/G cg23533926 chr12:111358616 MYL2 -0.39 -8.08 -0.3 3.13e-15 Extrinsic epigenetic age acceleration; BRCA trans rs1997103 1.000 rs4947504 chr7:55409428 T/C cg20935933 chr6:143382018 AIG1 0.58 11.17 0.4 1.32e-26 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.26 -0.49 3e-40 Platelet count; BRCA cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg11764359 chr7:65958608 NA 0.67 15.2 0.52 9.47e-45 Aortic root size; BRCA cis rs28830936 1.000 rs17734856 chr15:42045160 T/C cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.27 -0.34 2.72e-19 Diastolic blood pressure; BRCA cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA trans rs7618501 0.699 rs9821675 chr3:49902544 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.89 0.36 1.44e-21 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg24531977 chr5:56204891 C5orf35 -0.86 -17.98 -0.58 8.37e-59 Initial pursuit acceleration; BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.56 0.61 3.82e-67 Alzheimer's disease; BRCA trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg15556689 chr8:8085844 FLJ10661 -0.44 -11.79 -0.42 3.51e-29 Systolic blood pressure; BRCA cis rs4780401 0.609 rs16958588 chr16:11819330 G/A cg01061890 chr16:11836724 TXNDC11 -0.56 -13.34 -0.47 5.27e-36 Rheumatoid arthritis; BRCA cis rs96067 0.711 rs11263861 chr1:36628033 G/A cg24686825 chr1:36642396 MAP7D1 -0.4 -8.91 -0.33 5.08e-18 Corneal structure; BRCA cis rs9814567 0.806 rs4074523 chr3:134325657 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.72 -0.55 2.5e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.830 rs59751489 chr4:98933802 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg05868516 chr6:26286170 HIST1H4H 0.5 11.28 0.41 5.07e-27 Educational attainment; BRCA cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg11266682 chr4:10021025 SLC2A9 0.41 10.84 0.39 3.01e-25 Bone mineral density; BRCA cis rs2274273 0.967 rs67756714 chr14:55589823 G/A cg04306507 chr14:55594613 LGALS3 0.29 8.02 0.3 5.24e-15 Protein biomarker; BRCA cis rs1994135 0.617 rs10743824 chr12:33733764 C/T cg06521331 chr12:34319734 NA -0.42 -8.6 -0.32 6.19e-17 Resting heart rate; BRCA cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg10523679 chr1:76189770 ACADM 0.78 18.69 0.59 1.61e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs68170813 0.559 rs74898466 chr7:107053998 C/A cg02696742 chr7:106810147 HBP1 -0.49 -8.19 -0.31 1.46e-15 Coronary artery disease; BRCA cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg03806693 chr22:41940476 POLR3H -1.1 -19.77 -0.62 3.23e-68 Vitiligo; BRCA cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03576123 chr11:487126 PTDSS2 -1.08 -16.7 -0.55 3.22e-52 Body mass index; BRCA cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg03264133 chr6:25882463 NA -0.51 -10.87 -0.4 2.3e-25 Intelligence (multi-trait analysis); BRCA cis rs6740322 0.748 rs6544634 chr2:43471528 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.76 -14.9 -0.51 2.59e-43 Coronary artery disease; BRCA cis rs7312933 0.558 rs11181501 chr12:42822671 G/A cg01256987 chr12:42539512 GXYLT1 -0.42 -8.16 -0.31 1.75e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg09658497 chr7:2847517 GNA12 -0.41 -8.67 -0.32 3.66e-17 Height; BRCA cis rs698833 0.962 rs698829 chr2:44730846 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.7 0.36 7.9e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg20503657 chr10:835505 NA -0.54 -10.1 -0.37 2.4e-22 Response to angiotensin II receptor blocker therapy; BRCA trans rs6598955 0.671 rs12141563 chr1:26589636 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs1865721 0.804 rs62089468 chr18:73158850 C/T cg26385618 chr18:73139727 C18orf62 -0.44 -10.58 -0.39 3.31e-24 Intelligence; BRCA cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg16506815 chr2:162101123 NA 0.72 18.07 0.58 3.01e-59 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs67460515 0.563 rs16831981 chr3:160897780 T/C cg03342759 chr3:160939853 NMD3 -0.73 -15.36 -0.52 1.57e-45 Parkinson's disease; BRCA cis rs6570726 0.846 rs6919684 chr6:145883801 A/G cg23711669 chr6:146136114 FBXO30 0.71 16.8 0.55 9.7e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg08213375 chr14:104286397 PPP1R13B 0.49 11.09 0.4 2.92e-26 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.03 20.77 0.63 1.34e-73 Gut microbiome composition (summer); BRCA cis rs875971 0.964 rs778721 chr7:65845397 C/G cg18876405 chr7:65276391 NA 0.55 13.29 0.47 8.91e-36 Aortic root size; BRCA cis rs9790314 0.905 rs6774276 chr3:160941318 C/T cg03342759 chr3:160939853 NMD3 -0.65 -14.07 -0.49 2.32e-39 Morning vs. evening chronotype; BRCA cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg16179182 chr5:140090404 VTRNA1-1 0.45 10.68 0.39 1.27e-24 Depressive symptoms (multi-trait analysis); BRCA trans rs6582630 0.537 rs10785436 chr12:38461040 G/C cg06521331 chr12:34319734 NA -0.44 -8.39 -0.32 3.07e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs10189230 0.967 rs12479119 chr2:222354213 C/T cg14652038 chr2:222343519 EPHA4 0.47 13.13 0.46 4.83e-35 Urate levels in lean individuals; BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs2439831 0.850 rs11856795 chr15:44160582 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.7 0.36 7.31e-21 Lung cancer in ever smokers; BRCA cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg04450456 chr4:17643702 FAM184B 0.38 11.37 0.41 1.99e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9944715 1.000 rs4574015 chr18:43802126 T/C cg01718231 chr17:29326311 RNF135 -0.44 -8.49 -0.32 1.41e-16 Red cell distribution width;Mean corpuscular volume; BRCA cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg13119609 chr19:45449297 APOC2 0.48 13.24 0.46 1.5e-35 Blood protein levels; BRCA trans rs867371 0.519 rs1566559 chr15:82524461 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.32 -8.59 -0.32 6.76e-17 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs769267 1.000 rs769267 chr19:19446936 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.46 9.55 0.35 2.77e-20 Tonsillectomy; BRCA cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs644799 0.687 rs3748252 chr11:95519195 A/T cg25622487 chr11:95524042 FAM76B;CEP57 -0.81 -22.66 -0.67 6.85e-84 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.29 8.61 0.32 5.83e-17 Intelligence (multi-trait analysis); BRCA cis rs3008870 1.000 rs6673462 chr1:67461857 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 9.58 0.35 2.12e-20 Bipolar disorder; BRCA trans rs12517041 0.873 rs6886748 chr5:23307271 A/T ch.8.1293020R chr8:59333349 UBXN2B -0.48 -8.57 -0.32 8.03e-17 Calcium levels; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg00024416 chr22:24240387 NA -0.32 -7.91 -0.3 1.15e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1691799 0.899 rs1168328 chr12:66729250 T/C cg16791601 chr12:66731901 HELB -0.7 -19.79 -0.62 2.49e-68 White blood cell count (basophil); BRCA cis rs950776 0.593 rs680244 chr15:78871288 T/C cg06917634 chr15:78832804 PSMA4 -0.58 -12.85 -0.45 8.77e-34 Sudden cardiac arrest; BRCA cis rs7586879 0.639 rs2033656 chr2:25100902 C/G cg01884057 chr2:25150051 NA 0.31 8.17 0.31 1.65e-15 Body mass index; BRCA cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7572733 0.555 rs6745726 chr2:198934080 A/G cg00792783 chr2:198669748 PLCL1 0.39 8.32 0.31 5.52e-16 Dermatomyositis; BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.4 9.45 0.35 6.29e-20 Tonsillectomy; BRCA cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg27129171 chr3:47204927 SETD2 -0.61 -14.2 -0.49 5.94e-40 Colorectal cancer; BRCA cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg07148914 chr20:33460835 GGT7 -0.37 -7.99 -0.3 6.25e-15 Glomerular filtration rate (creatinine); BRCA cis rs6582630 0.519 rs11181526 chr12:38360230 A/G cg13010199 chr12:38710504 ALG10B 0.45 9.38 0.35 1.16e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs2463822 0.925 rs1881535 chr11:62121623 C/T cg06239285 chr11:62104954 ASRGL1 0.69 11.52 0.41 4.72e-28 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1018836 0.847 rs4735226 chr8:91569238 T/A cg16814680 chr8:91681699 NA -0.64 -14.22 -0.49 4.45e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg01475377 chr6:109611718 NA -0.54 -13.98 -0.48 5.8e-39 Reticulocyte fraction of red cells; BRCA cis rs6820391 0.816 rs1567654 chr4:54448177 C/T cg04173182 chr4:54446035 LNX1 0.51 11.57 0.42 2.97e-28 Cervical artery dissection; BRCA cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg05347473 chr6:146136440 FBXO30 0.41 7.96 0.3 8.08e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs17685 0.725 rs4728548 chr7:75654632 A/T cg19862616 chr7:65841803 NCRNA00174 -0.67 -18.32 -0.59 1.38e-60 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg12444411 chr7:2802554 GNA12 -0.39 -9.36 -0.35 1.36e-19 Height; BRCA trans rs4596713 0.508 rs4745650 chr9:71777892 G/A cg16512924 chr15:28394682 HERC2 0.45 10.58 0.39 3.12e-24 Headache; BRCA cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg06060754 chr5:176797920 RGS14 0.58 11.05 0.4 4.27e-26 Hemoglobin concentration;Hematocrit; BRCA cis rs12500482 0.935 rs2239736 chr4:2438929 T/C cg08330972 chr4:2403930 ZFYVE28 -0.33 -8.68 -0.32 3.22e-17 Cognitive function; BRCA cis rs1891275 0.515 rs1986941 chr10:93444343 C/T cg07889827 chr10:93443413 NA -0.44 -12.37 -0.44 1.18e-31 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg12311346 chr5:56204834 C5orf35 -0.82 -16.75 -0.55 1.84e-52 Initial pursuit acceleration; BRCA cis rs250677 0.687 rs250674 chr5:148438597 A/G cg12140854 chr5:148520817 ABLIM3 0.42 8.91 0.33 5.37e-18 Breast cancer; BRCA trans rs35110281 0.627 rs6518268 chr21:44967448 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.03 0.37 4.5e-22 Mean corpuscular volume; BRCA cis rs11190604 1.000 rs7085439 chr10:102210100 C/T cg07080220 chr10:102295463 HIF1AN 0.49 11.34 0.41 2.85e-27 Palmitoleic acid (16:1n-7) levels; BRCA trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -9.44 -0.35 6.77e-20 Triglycerides; BRCA cis rs6580649 1.000 rs7305954 chr12:48403530 C/T cg05342945 chr12:48394962 COL2A1 -0.43 -8.87 -0.33 7.28e-18 Lung cancer; BRCA cis rs1448094 0.512 rs61930137 chr12:86242930 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.31 -0.35 2.09e-19 Major depressive disorder; BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg25036284 chr2:26402008 FAM59B -0.78 -12.14 -0.43 1.11e-30 Gut microbiome composition (summer); BRCA cis rs589448 0.902 rs315131 chr12:69761839 T/G cg22834771 chr12:69754056 YEATS4 -0.42 -10.56 -0.39 3.78e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs66782572 1 rs66782572 chr3:52567617 A/G cg18404041 chr3:52824283 ITIH1 -0.28 -8.61 -0.32 5.49e-17 Hemoglobin concentration; BRCA cis rs13191362 1.000 rs34697913 chr6:163000187 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3806843 0.838 rs2262567 chr5:140132134 T/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.16 0.34 7.11e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg11266682 chr4:10021025 SLC2A9 0.49 13.09 0.46 7.74e-35 Bone mineral density; BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00166722 chr3:10149974 C3orf24 0.66 13.1 0.46 6.48e-35 Alzheimer's disease; BRCA cis rs72848980 0.512 rs61151381 chr10:105370496 C/G cg00126946 chr10:105363258 SH3PXD2A 0.46 8.88 0.33 6.9e-18 White matter hyperintensity burden; BRCA cis rs9473147 0.543 rs9367279 chr6:47448336 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.56 0.35 2.48e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs4906332 1.000 rs17617832 chr14:103943140 T/C cg26031613 chr14:104095156 KLC1 -0.44 -8.0 -0.3 6.01e-15 Coronary artery disease; BRCA cis rs6684514 0.961 rs72710222 chr1:156285995 T/C cg16558208 chr1:156270281 VHLL 0.34 8.11 0.31 2.62e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs889312 0.500 rs832585 chr5:56125904 T/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.51 -0.32 1.21e-16 Breast cancer;Breast cancer (early onset); BRCA cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg07395648 chr5:131743802 NA 0.37 8.15 0.31 1.96e-15 Breast cancer; BRCA cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg20908204 chr19:46285434 DMPK -0.29 -8.65 -0.32 4.16e-17 Coronary artery disease; BRCA cis rs17253792 0.822 rs74824071 chr14:56095142 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs2011503 0.739 rs8108659 chr19:19680738 T/A cg11584989 chr19:19387371 SF4 -0.47 -9.53 -0.35 3.16e-20 Bipolar disorder; BRCA cis rs10504073 0.647 rs11997959 chr8:50014044 C/T cg00325661 chr8:49890786 NA 0.38 11.26 0.41 5.95e-27 Blood metabolite ratios; BRCA cis rs3925075 1.000 rs3925074 chr16:31347807 G/A cg02846316 chr16:31340340 ITGAM 0.53 13.26 0.46 1.25e-35 IgA nephropathy; BRCA cis rs34779708 0.966 rs35079558 chr10:35479886 A/G cg03585969 chr10:35415529 CREM 0.55 11.29 0.41 4.53e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9393692 0.905 rs7746807 chr6:26293338 C/A cg13736514 chr6:26305472 NA -0.37 -12.54 -0.44 2.16e-32 Educational attainment; BRCA cis rs9470366 0.545 rs2395655 chr6:36645696 C/T cg08179530 chr6:36648295 CDKN1A -0.73 -18.36 -0.59 9.16e-61 QRS duration; BRCA cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg26513180 chr16:89883248 FANCA -0.57 -13.24 -0.46 1.63e-35 Vitiligo; BRCA cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg03452623 chr4:187889614 NA -0.31 -10.14 -0.37 1.7e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs8114671 0.562 rs4911164 chr20:33479488 G/C cg07148914 chr20:33460835 GGT7 0.47 9.98 0.37 6.74e-22 Height; BRCA cis rs67460515 0.852 rs2404341 chr3:161092405 T/C cg03342759 chr3:160939853 NMD3 -0.72 -16.35 -0.54 1.83e-50 Parkinson's disease; BRCA cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg00071950 chr4:10020882 SLC2A9 0.54 13.22 0.46 1.87e-35 Bone mineral density; BRCA cis rs3125734 0.633 rs4979772 chr10:63967600 C/T cg19640130 chr10:64028056 RTKN2 0.31 8.97 0.33 3.23e-18 Rheumatoid arthritis; BRCA cis rs9733 0.744 rs11204725 chr1:150742700 T/C cg18016565 chr1:150552671 MCL1 -0.37 -8.56 -0.32 8.71e-17 Tonsillectomy; BRCA cis rs2191566 0.576 rs370809 chr19:44493830 C/T cg20607764 chr19:44506953 ZNF230 0.36 7.87 0.3 1.5e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs11608355 0.515 rs11610558 chr12:109925865 C/T cg05360138 chr12:110035743 NA 0.74 13.54 0.47 6.41e-37 Neuroticism; BRCA cis rs2204008 0.837 rs11168504 chr12:37964922 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.97 0.37 7.65e-22 Bladder cancer; BRCA cis rs2425143 1.000 rs4504072 chr20:34448773 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.54 -0.32 9.92e-17 Blood protein levels; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg24642844 chr7:1081250 C7orf50 -0.89 -16.29 -0.54 3.52e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7586879 0.521 rs1865689 chr2:25108197 C/T cg04586622 chr2:25135609 ADCY3 -0.45 -11.48 -0.41 7.52e-28 Body mass index; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6835098 0.924 rs2332669 chr4:174163398 G/A cg08422745 chr4:174089978 GALNT7 -0.67 -13.77 -0.48 6.08e-38 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs2191566 0.576 rs381983 chr19:44494215 C/T cg20607764 chr19:44506953 ZNF230 -0.38 -8.26 -0.31 8.33e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg25019033 chr10:957182 NA -0.42 -8.8 -0.33 1.27e-17 Eosinophil percentage of granulocytes; BRCA cis rs8072100 0.656 rs2610367 chr17:45569815 A/G cg08085267 chr17:45401833 C17orf57 -0.62 -12.7 -0.45 4.19e-33 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11229555 0.874 rs7102852 chr11:58358348 G/A cg15696309 chr11:58395628 NA -0.53 -11.5 -0.41 5.77e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs11098499 0.866 rs6824111 chr4:120285968 T/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs312273 0.743 rs10879395 chr12:41340452 C/G cg17827154 chr12:41323612 CNTN1 -0.43 -11.12 -0.4 2.11e-26 Bipolar disorder; BRCA trans rs3733585 0.579 rs4235356 chr4:10123106 G/C cg26043149 chr18:55253948 FECH -0.4 -8.52 -0.32 1.14e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.46 -9.34 -0.35 1.62e-19 Tonsillectomy; BRCA cis rs6582630 0.555 rs11181657 chr12:38381858 T/C cg13010199 chr12:38710504 ALG10B -0.41 -8.63 -0.32 4.86e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs9399135 0.967 rs12527707 chr6:135324511 G/A cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 8.89e-33 Red blood cell count; BRCA cis rs7666738 0.830 rs13121558 chr4:99002848 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs9560113 0.959 rs9555803 chr13:112179560 G/T cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11644478 chr21:40555479 PSMG1 0.86 20.42 0.63 9.86e-72 Cognitive function; BRCA cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg07606381 chr6:8435919 SLC35B3 -0.58 -12.45 -0.44 4.98e-32 Motion sickness; BRCA cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.76 -0.33 1.7e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg03709012 chr19:19516395 GATAD2A 0.72 15.68 0.53 4.14e-47 Tonsillectomy; BRCA cis rs8032158 1.000 rs8024944 chr15:56125135 C/A cg02198044 chr15:56286336 NEDD4 -0.38 -9.04 -0.34 1.8e-18 Keloid; BRCA cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg05347473 chr6:146136440 FBXO30 0.41 7.93 0.3 9.73e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg21782813 chr7:2030301 MAD1L1 0.32 8.7 0.33 2.75e-17 Schizophrenia; BRCA cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.67 0.39 1.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg11890956 chr21:40555474 PSMG1 -0.86 -22.07 -0.66 1.11e-80 Cognitive function; BRCA cis rs7715806 0.500 rs888788 chr5:74988336 C/T cg19683494 chr5:74908142 NA 0.53 8.55 0.32 8.75e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg17971929 chr21:40555470 PSMG1 0.79 19.04 0.6 2.41e-64 Cognitive function; BRCA cis rs7246657 0.606 rs2972439 chr19:38212581 T/C cg18154014 chr19:37997991 ZNF793 -0.49 -9.39 -0.35 1.03e-19 Coronary artery calcification; BRCA cis rs208515 0.525 rs12214310 chr6:66666308 A/G cg07460842 chr6:66804631 NA 0.85 15.31 0.52 2.76e-45 Exhaled nitric oxide levels; BRCA trans rs12310956 0.532 rs1352211 chr12:33983132 G/A cg26384229 chr12:38710491 ALG10B 0.51 11.03 0.4 4.98e-26 Morning vs. evening chronotype; BRCA cis rs3733585 0.673 rs6836706 chr4:9964251 T/A cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.7 -15.91 -0.53 3.09e-48 Multiple sclerosis; BRCA cis rs17401966 0.540 rs4846199 chr1:10283961 A/G cg03954927 chr1:10346856 KIF1B 0.35 10.61 0.39 2.39e-24 Hepatocellular carcinoma; BRCA cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg21132104 chr15:45694354 SPATA5L1 0.74 16.96 0.56 1.57e-53 Homoarginine levels; BRCA cis rs2882667 0.931 rs10038799 chr5:138362283 C/T cg04439458 chr5:138467593 SIL1 -0.33 -8.89 -0.33 6.09e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2836950 0.565 rs8130320 chr21:40580258 C/T cg11644478 chr21:40555479 PSMG1 -0.51 -10.89 -0.4 1.85e-25 Menarche (age at onset); BRCA cis rs2559856 0.967 rs2559863 chr12:102087108 C/T cg12924262 chr12:102091054 CHPT1 0.42 9.53 0.35 3.32e-20 Blood protein levels; BRCA cis rs6964587 0.782 rs13221571 chr7:91500236 C/T cg17063962 chr7:91808500 NA -0.53 -12.62 -0.45 9.07e-33 Breast cancer; BRCA cis rs6450176 0.909 rs3776712 chr5:53304179 T/C ch.5.1024479R chr5:53302184 ARL15 -0.61 -15.01 -0.51 7.93e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9814567 1.000 rs9841212 chr3:134191938 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.4 -0.57 8.12e-56 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7572733 0.534 rs2574832 chr2:198704818 T/G cg00792783 chr2:198669748 PLCL1 0.47 10.18 0.37 1.16e-22 Dermatomyositis; BRCA cis rs9399137 0.507 rs10484496 chr6:135299682 T/C cg22676075 chr6:135203613 NA 0.44 8.59 0.32 6.47e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs12973672 1.000 rs10405246 chr19:35768949 A/G cg12095397 chr19:35769544 USF2 0.37 8.3 0.31 5.97e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs61931739 0.500 rs34418276 chr12:34535976 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.64 0.36 1.23e-20 Morning vs. evening chronotype; BRCA cis rs8180040 0.654 rs62246451 chr3:47211632 C/T cg16586182 chr3:47516702 SCAP 0.56 12.53 0.44 2.25e-32 Colorectal cancer; BRCA cis rs12711979 0.509 rs10187740 chr2:3823965 A/G cg17052675 chr2:3827356 NA 0.7 23.56 0.68 8.31e-89 Itch intensity from mosquito bite adjusted by bite size; BRCA trans rs79976124 0.797 rs79522358 chr6:66641140 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.76 0.39 6.29e-25 Type 2 diabetes; BRCA cis rs9549260 0.753 rs10507486 chr13:41186501 A/G cg21288729 chr13:41239152 FOXO1 -0.51 -8.3 -0.31 6.29e-16 Red blood cell count; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg18301423 chr5:131593218 PDLIM4 -0.35 -8.29 -0.31 6.83e-16 Acylcarnitine levels; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -12.35 -0.44 1.38e-31 Bipolar disorder and schizophrenia; BRCA cis rs1451375 0.583 rs3779078 chr7:50610918 C/T cg18232548 chr7:50535776 DDC 0.44 9.27 0.34 2.76e-19 Malaria; BRCA cis rs2243480 0.808 rs12698508 chr7:65411958 A/T cg18252515 chr7:66147081 NA -0.9 -12.94 -0.46 3.62e-34 Diabetic kidney disease; BRCA cis rs2663905 1.000 rs2663905 chr15:81359137 G/A cg09888468 chr15:81410853 NA -0.47 -9.7 -0.36 7.48e-21 QT interval (drug interaction); BRCA cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg21573476 chr21:45109991 RRP1B -0.42 -11.11 -0.4 2.42e-26 Mean corpuscular volume; BRCA cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 10.64 0.39 1.95e-24 Aortic root size; BRCA cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg25703541 chr22:24373054 LOC391322 0.63 12.57 0.45 1.5e-32 Urinary 1,3-butadiene metabolite levels in smokers; BRCA trans rs61931739 0.500 rs34107854 chr12:34482333 C/A cg26384229 chr12:38710491 ALG10B 0.74 16.49 0.55 3.62e-51 Morning vs. evening chronotype; BRCA cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg11752832 chr7:134001865 SLC35B4 0.55 14.14 0.49 1.13e-39 Mean platelet volume; BRCA cis rs12291225 0.679 rs11023178 chr11:14310282 G/A cg19336497 chr11:14380999 RRAS2 -0.48 -11.87 -0.42 1.69e-29 Sense of smell; BRCA cis rs9296092 0.538 rs112113649 chr6:33524529 A/G cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.28e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg20203395 chr5:56204925 C5orf35 -0.5 -10.12 -0.37 1.97e-22 Initial pursuit acceleration; BRCA cis rs7769051 1.000 rs7769051 chr6:133146796 G/T cg22852734 chr6:133119734 C6orf192 0.73 12.18 0.43 7.45e-31 Type 2 diabetes nephropathy; BRCA cis rs875971 0.545 rs1796219 chr7:66110964 A/G cg11764359 chr7:65958608 NA -0.59 -9.85 -0.36 2.06e-21 Aortic root size; BRCA cis rs1011018 0.628 rs76600942 chr7:139449942 G/A cg03224163 chr7:139420300 HIPK2 -0.6 -9.0 -0.34 2.66e-18 Systolic blood pressure; BRCA cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs208520 0.874 rs208469 chr6:66915891 T/C cg07460842 chr6:66804631 NA -0.89 -15.72 -0.53 2.64e-47 Exhaled nitric oxide output; BRCA cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg21573476 chr21:45109991 RRP1B -0.34 -8.82 -0.33 1.1e-17 Mean corpuscular volume; BRCA cis rs7809950 0.911 rs7778250 chr7:107224565 C/A cg23024343 chr7:107201750 COG5 0.42 8.95 0.33 3.94e-18 Coronary artery disease; BRCA cis rs4808199 1.000 rs7258508 chr19:19475469 T/C cg01262667 chr19:19385393 TM6SF2 0.39 8.02 0.3 5.11e-15 Nonalcoholic fatty liver disease; BRCA cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.09 0.3 3e-15 Aortic root size; BRCA cis rs10193935 0.901 rs6733914 chr2:42674741 A/G cg27598129 chr2:42591480 NA 0.85 14.03 0.49 3.51e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.76 0.48 6.16e-38 Platelet count; BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg21143896 chr7:2802374 GNA12 -0.33 -8.6 -0.32 6.03e-17 Height; BRCA cis rs7587476 1.000 rs7587476 chr2:215653887 T/C cg04004882 chr2:215674386 BARD1 -0.58 -11.0 -0.4 6.57e-26 Neuroblastoma; BRCA cis rs9420 0.961 rs7949841 chr11:57524700 G/C cg19752551 chr11:57585705 CTNND1 -0.51 -12.58 -0.45 1.37e-32 Schizophrenia; BRCA cis rs7246657 1.000 rs1529957 chr19:37739801 A/G cg14683738 chr19:37701593 ZNF585B 0.48 8.28 0.31 7.32e-16 Coronary artery calcification; BRCA cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg23711669 chr6:146136114 FBXO30 0.72 17.44 0.57 5.23e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs1011018 0.628 rs78366882 chr7:139452776 C/A cg03224163 chr7:139420300 HIPK2 -0.59 -8.91 -0.33 5.15e-18 Systolic blood pressure; BRCA trans rs9944715 0.954 rs9952469 chr18:43812010 T/C cg01718231 chr17:29326311 RNF135 -0.42 -8.65 -0.32 4.32e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs74181299 0.684 rs10185243 chr2:65355744 G/T cg05010058 chr2:65284262 CEP68 -0.3 -8.11 -0.31 2.52e-15 Pulse pressure; BRCA cis rs2073300 1.000 rs12625804 chr20:23441981 G/A cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10504229 0.953 rs57131327 chr8:58171895 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.64 -0.5 4.62e-42 Chronic sinus infection; BRCA cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg05623727 chr3:50126028 RBM5 -0.52 -12.5 -0.44 3.12e-32 Body mass index; BRCA cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA trans rs561341 0.769 rs8074383 chr17:30178793 C/T cg27661571 chr11:113659931 NA 0.65 8.71 0.33 2.53e-17 Hip circumference adjusted for BMI; BRCA cis rs7833790 0.929 rs10958048 chr8:82792914 C/T cg17211192 chr8:82754475 SNX16 0.56 10.24 0.38 7.15e-23 Diastolic blood pressure; BRCA trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg03929089 chr4:120376271 NA -0.94 -25.48 -0.71 2.42e-99 Height; BRCA cis rs1003719 0.788 rs2835595 chr21:38466203 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2806561 0.929 rs6669568 chr1:23540469 G/A cg12483005 chr1:23474871 LUZP1 -0.37 -8.03 -0.3 4.71e-15 Height; BRCA cis rs727479 0.543 rs1143704 chr15:51510702 T/A cg19946085 chr15:51559439 CYP19A1 -0.29 -8.18 -0.31 1.51e-15 Estradiol levels; BRCA cis rs73086581 1.000 rs6052217 chr20:3970211 A/G cg02187196 chr20:3869020 PANK2 0.51 9.22 0.34 4.42e-19 Response to antidepressants in depression; BRCA trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg00717180 chr2:96193071 NA -0.38 -10.2 -0.37 9.44e-23 HDL cholesterol; BRCA trans rs7200543 1.000 rs4500751 chr16:15140211 C/T cg24683922 chr1:11983373 KIAA2013 -0.35 -8.24 -0.31 9.86e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg11608241 chr8:8085544 FLJ10661 0.31 8.88 0.33 6.91e-18 Mood instability; BRCA trans rs1991651 0.578 rs11778453 chr8:10489836 C/G cg06636001 chr8:8085503 FLJ10661 -0.43 -8.5 -0.32 1.38e-16 Granulocyte count;Neutrophil count;Myeloid white cell count;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts; BRCA cis rs7044106 0.762 rs1158554 chr9:123400898 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 16.16 0.54 1.72e-49 Hip circumference adjusted for BMI; BRCA cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg23625390 chr15:77176239 SCAPER 0.39 9.15 0.34 7.8e-19 Blood metabolite levels; BRCA cis rs6840360 0.593 rs6855883 chr4:152688997 A/G cg22705602 chr4:152727874 NA -0.38 -10.47 -0.38 8.45e-24 Intelligence (multi-trait analysis); BRCA cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg16339924 chr4:17578868 LAP3 -0.6 -14.6 -0.5 6.84e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4900538 0.855 rs72698602 chr14:102880454 T/C cg18135206 chr14:102964638 TECPR2 -0.92 -21.74 -0.65 7.08e-79 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg17330251 chr7:94953956 PON1 -0.42 -9.06 -0.34 1.53e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs73242632 1.000 rs28719609 chr4:57881862 T/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.69 8.27 0.31 8.02e-16 Congenital heart disease (maternal effect); BRCA cis rs4076764 0.957 rs4443867 chr1:163434917 T/C cg06092702 chr1:163392909 NA -0.33 -8.68 -0.32 3.38e-17 Motion sickness; BRCA cis rs2191566 0.576 rs436790 chr19:44491927 A/G cg20607764 chr19:44506953 ZNF230 -0.37 -8.01 -0.3 5.53e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs1538970 0.924 rs12046816 chr1:45891543 G/T cg05343316 chr1:45956843 TESK2 0.62 12.56 0.44 1.76e-32 Platelet count; BRCA cis rs7264396 1.000 rs224418 chr20:34142527 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -10.97 -0.4 8.81e-26 Total cholesterol levels; BRCA cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg20607287 chr7:12443886 VWDE -0.6 -8.53 -0.32 1.04e-16 Coronary artery disease; BRCA cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg05535760 chr7:792225 HEATR2 -0.73 -11.6 -0.42 2.2e-28 Cerebrospinal P-tau181p levels; BRCA cis rs829883 1.000 rs249839 chr12:98872364 T/C cg25150519 chr12:98850993 NA 0.58 11.77 0.42 4.47e-29 Colorectal adenoma (advanced); BRCA trans rs2739330 0.828 rs5751770 chr22:24252842 A/G cg06437703 chr8:37914619 EIF4EBP1 -0.31 -8.2 -0.31 1.34e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9283706 0.689 rs12517976 chr5:66321579 G/A cg11590213 chr5:66331682 MAST4 0.42 8.08 0.3 3.2e-15 Coronary artery disease; BRCA cis rs929596 0.518 rs13401281 chr2:234628679 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -10.52 -0.38 5.58e-24 Total bilirubin levels in HIV-1 infection; BRCA cis rs11690935 0.788 rs10201053 chr2:172889558 A/G cg13550731 chr2:172543902 DYNC1I2 -0.79 -21.9 -0.65 9.9e-80 Schizophrenia; BRCA cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg23649088 chr2:200775458 C2orf69 -0.61 -7.95 -0.3 8.69e-15 Schizophrenia; BRCA cis rs9473147 0.516 rs2151975 chr6:47515663 T/C cg12968598 chr6:47444699 CD2AP 0.44 9.76 0.36 4.44e-21 Platelet distribution width;Mean platelet volume; BRCA trans rs11098499 0.754 rs10518300 chr4:120249499 G/T cg25214090 chr10:38739885 LOC399744 -0.46 -10.47 -0.38 8.76e-24 Corneal astigmatism; BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg11062466 chr8:58055876 NA 0.5 8.56 0.32 8.24e-17 Developmental language disorder (linguistic errors); BRCA cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.31 -8.15 -0.31 1.87e-15 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA cis rs7580658 0.926 rs4662725 chr2:128141320 G/A cg09760422 chr2:128146352 NA -0.35 -7.84 -0.3 1.83e-14 Protein C levels; BRCA cis rs6763687 0.585 rs10936710 chr3:171801991 T/C cg16233210 chr3:171778391 FNDC3B 0.35 7.81 0.3 2.39e-14 Red cell distribution width; BRCA trans rs60843830 1.000 rs60484953 chr2:221560 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 14.59 0.5 8.38e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1847202 0.859 rs7634316 chr3:72941452 C/G cg25664220 chr3:72788482 NA 0.37 8.56 0.32 8.28e-17 Motion sickness; BRCA cis rs7651736 1.000 rs7651736 chr3:136760598 A/G cg12473912 chr3:136751656 NA 0.37 8.26 0.31 8.34e-16 Neuroticism; BRCA cis rs507080 0.922 rs514143 chr11:118558449 G/A cg09144398 chr11:118550485 TREH -0.38 -9.09 -0.34 1.23e-18 Serum metabolite levels; BRCA trans rs66887589 0.774 rs9307477 chr4:120421809 G/A cg25214090 chr10:38739885 LOC399744 0.35 7.93 0.3 9.99e-15 Diastolic blood pressure; BRCA cis rs10504073 0.584 rs4873304 chr8:49922733 G/A cg00325661 chr8:49890786 NA 0.54 15.54 0.52 1.89e-46 Blood metabolite ratios; BRCA cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg08392591 chr16:89556376 ANKRD11 0.38 8.91 0.33 5.27e-18 Multiple myeloma (IgH translocation); BRCA cis rs2153535 0.526 rs9406179 chr6:8538224 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.66 0.32 3.7e-17 Motion sickness; BRCA cis rs6500602 0.627 rs1641866 chr16:4593040 A/C cg08645402 chr16:4508243 NA 0.35 7.94 0.3 8.83e-15 Schizophrenia; BRCA cis rs6430585 0.528 rs16832205 chr2:136684632 G/A cg07169764 chr2:136633963 MCM6 1.22 23.93 0.69 7.64e-91 Corneal structure; BRCA cis rs11779988 0.545 rs454692 chr8:17789298 T/C cg01800426 chr8:17659068 MTUS1 -0.4 -8.23 -0.31 1.02e-15 Breast cancer; BRCA cis rs62064224 0.675 rs12150479 chr17:30636200 T/A cg25809561 chr17:30822961 MYO1D 0.4 9.52 0.35 3.4e-20 Schizophrenia; BRCA cis rs9815354 0.767 rs17280980 chr3:41810949 A/T cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA trans rs11098499 0.954 rs6857105 chr4:120222298 C/G cg25214090 chr10:38739885 LOC399744 0.49 10.75 0.39 7.05e-25 Corneal astigmatism; BRCA cis rs9837602 0.938 rs793457 chr3:99518987 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -10.41 -0.38 1.56e-23 Breast cancer; BRCA cis rs12348691 0.503 rs7849834 chr9:100606188 T/C cg13688889 chr9:100608707 NA -0.49 -10.03 -0.37 4.39e-22 Alopecia areata; BRCA cis rs4481887 1.000 rs6681423 chr1:248482834 C/A cg00666640 chr1:248458726 OR2T12 0.34 9.12 0.34 9.72e-19 Common traits (Other); BRCA cis rs7917772 0.582 rs4917978 chr10:104366353 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.48 -14.58 -0.5 8.75e-42 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1401999 0.898 rs4148564 chr3:183725982 C/T cg01324343 chr3:183735012 ABCC5 0.84 21.36 0.65 8.57e-77 Anterior chamber depth; BRCA cis rs2576037 0.796 rs2571018 chr18:44585344 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.41 8.44 0.32 2.1e-16 Personality dimensions; BRCA cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg09467607 chr2:36825704 FEZ2 -0.65 -17.41 -0.57 7.35e-56 Height; BRCA cis rs9296092 0.538 rs62405943 chr6:33517359 A/G cg13560919 chr6:33536144 NA -0.85 -18.39 -0.59 6.37e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.31 -0.38 3.67e-23 Gut microbiome composition (summer); BRCA cis rs36051895 0.632 rs11788963 chr9:5120157 C/A cg02405213 chr9:5042618 JAK2 -0.49 -8.91 -0.33 5.39e-18 Pediatric autoimmune diseases; BRCA cis rs1371867 0.846 rs959022 chr8:101295992 T/A cg06002616 chr8:101225028 SPAG1 -0.34 -8.3 -0.31 6.4e-16 Atrioventricular conduction; BRCA cis rs10876993 0.928 rs2640636 chr12:58077544 A/G cg18357645 chr12:58087776 OS9 0.48 13.8 0.48 4.11e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs7953249 0.502 rs1169294 chr12:121426594 G/A cg02403541 chr12:121454288 C12orf43 0.51 9.46 0.35 5.95e-20 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.06 -0.4 3.81e-26 Lymphocyte counts; BRCA cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg27398817 chr8:82754497 SNX16 -0.37 -7.86 -0.3 1.58e-14 Diastolic blood pressure; BRCA cis rs4074536 0.796 rs10157905 chr1:116308511 C/T cg21648376 chr1:116311395 CASQ2 -0.5 -8.91 -0.33 5.16e-18 QRS duration; BRCA cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.59e-84 Chronic sinus infection; BRCA cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg12311346 chr5:56204834 C5orf35 0.81 16.55 0.55 1.75e-51 Initial pursuit acceleration; BRCA cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.36e-17 Developmental language disorder (linguistic errors); BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg18538332 chr22:24372958 LOC391322 -0.56 -14.13 -0.49 1.25e-39 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1401999 0.966 rs2313212 chr3:183700928 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.11 0.37 2.09e-22 Anterior chamber depth; BRCA cis rs10911363 0.550 rs10911353 chr1:183489203 G/A cg09173681 chr1:183549694 NCF2 0.53 11.12 0.4 2.31e-26 Systemic lupus erythematosus; BRCA cis rs870825 0.616 rs28673855 chr4:185627416 T/G cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs2304069 0.955 rs4288106 chr5:149394872 A/G cg12661370 chr5:149340060 SLC26A2 0.56 8.36 0.31 3.8e-16 HIV-1 control; BRCA cis rs72781680 0.898 rs72788212 chr2:24087385 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.0 0.34 2.55e-18 Lymphocyte counts; BRCA trans rs7786808 0.615 rs1563066 chr7:158194935 A/C cg02030672 chr11:45687055 CHST1 0.5 11.35 0.41 2.44e-27 Obesity-related traits; BRCA cis rs909002 0.811 rs11575883 chr1:32085485 G/A cg13919466 chr1:32135498 COL16A1 -0.27 -9.42 -0.35 8.34e-20 Intelligence (multi-trait analysis); BRCA cis rs4845875 0.557 rs4846054 chr1:11869230 C/T cg24844545 chr1:11908347 NPPA 0.34 8.83 0.33 1.04e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs7818345 0.967 rs12679671 chr8:19270831 G/T cg11303988 chr8:19266685 CSGALNACT1 0.32 8.23 0.31 1.07e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.83 -0.36 2.39e-21 Aortic root size; BRCA cis rs870825 0.616 rs55685500 chr4:185614810 G/A cg20176042 chr4:185552304 CASP3 -0.54 -8.2 -0.31 1.28e-15 Blood protein levels; BRCA cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg24110177 chr3:50126178 RBM5 0.52 15.68 0.53 4e-47 Body mass index; BRCA cis rs832540 0.966 rs252923 chr5:56205662 T/G cg12311346 chr5:56204834 C5orf35 -0.38 -7.9 -0.3 1.23e-14 Coronary artery disease; BRCA cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.56 0.32 8.33e-17 Rheumatoid arthritis; BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg03709012 chr19:19516395 GATAD2A 0.81 19.06 0.6 1.89e-64 Tonsillectomy; BRCA cis rs2303759 0.958 rs1465697 chr19:49837246 C/T cg22307029 chr19:49891270 CCDC155 0.58 10.14 0.37 1.71e-22 Multiple sclerosis; BRCA cis rs6542838 0.609 rs13028500 chr2:99528296 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.44 -9.98 -0.37 6.66e-22 Fear of minor pain; BRCA cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.4 -0.35 9.22e-20 Body mass index; BRCA cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg19628046 chr18:33552617 C18orf21 0.52 9.99 0.37 6.09e-22 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2288073 0.930 rs7604097 chr2:24401805 G/C cg06627628 chr2:24431161 ITSN2 -0.63 -11.98 -0.43 5.58e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs17253792 0.545 rs12893610 chr14:56016347 C/T cg01858014 chr14:56050164 KTN1 -0.63 -8.27 -0.31 7.6e-16 Putamen volume; BRCA cis rs7666738 0.830 rs13141752 chr4:98893128 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.84 0.36 2.22e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.43 0.57 5.62e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.943 rs10424574 chr19:37838393 A/G cg18154014 chr19:37997991 ZNF793 0.61 11.43 0.41 1.13e-27 Coronary artery calcification; BRCA cis rs172166 0.694 rs1225716 chr6:28113746 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.26 8.13 0.31 2.21e-15 Cardiac Troponin-T levels; BRCA cis rs11792861 0.962 rs3750452 chr9:111801353 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.17 0.31 1.62e-15 Menarche (age at onset); BRCA cis rs9309473 1.000 rs6755217 chr2:73641285 C/T cg20560298 chr2:73613845 ALMS1 -0.49 -11.97 -0.43 6.34e-30 Metabolite levels; BRCA cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg03351412 chr1:154909251 PMVK 0.57 13.04 0.46 1.31e-34 Prostate cancer; BRCA cis rs7072216 0.763 rs6584201 chr10:100170209 T/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs7481584 0.624 rs369461 chr11:3061992 A/G cg25174290 chr11:3078921 CARS -0.3 -7.97 -0.3 7.18e-15 Calcium levels; BRCA cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg02297831 chr4:17616191 MED28 0.36 8.43 0.32 2.25e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg11584989 chr19:19387371 SF4 0.63 13.41 0.47 2.68e-36 Bipolar disorder; BRCA cis rs12579753 1.000 rs12811607 chr12:82233619 T/G cg07988820 chr12:82153109 PPFIA2 -0.64 -10.39 -0.38 1.86e-23 Resting heart rate; BRCA cis rs11711311 1.000 rs2712348 chr3:113460614 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.35 9.19 0.34 5.44e-19 IgG glycosylation; BRCA cis rs2576037 0.526 rs2032215 chr18:44439011 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.57 0.32 7.85e-17 Personality dimensions; BRCA cis rs743757 1.000 rs2236975 chr3:50483437 A/G cg05260129 chr3:50388622 TUSC4;CYB561D2 0.46 7.88 0.3 1.43e-14 Diastolic blood pressure; BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs11605924 1.000 rs1401419 chr11:45879739 T/C ch.11.939596F chr11:45881766 CRY2 -0.47 -10.41 -0.38 1.56e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs703842 0.616 rs4760332 chr12:58222672 A/C cg00677455 chr12:58241039 CTDSP2 -0.75 -17.07 -0.56 4.33e-54 Multiple sclerosis; BRCA cis rs1997103 1.000 rs2177804 chr7:55410302 G/A cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.81 0.3 2.32e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs615632 0.530 rs10092464 chr8:9804185 C/G cg06636001 chr8:8085503 FLJ10661 -0.43 -7.98 -0.3 6.62e-15 Neuroticism; BRCA cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg11764359 chr7:65958608 NA 0.47 9.13 0.34 8.92e-19 Calcium levels; BRCA cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.686 rs1045820 chr6:145947080 C/T cg23711669 chr6:146136114 FBXO30 0.71 16.76 0.55 1.49e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.72 10.25 0.38 6.11e-23 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1499972 0.941 rs73168378 chr3:117636234 G/T cg07612923 chr3:117604196 NA 0.6 8.16 0.31 1.75e-15 Schizophrenia; BRCA cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg19717773 chr7:2847554 GNA12 -0.42 -9.51 -0.35 3.68e-20 Height; BRCA cis rs208520 1.000 rs72884017 chr6:66992513 T/G cg07460842 chr6:66804631 NA 0.88 14.14 0.49 1.11e-39 Exhaled nitric oxide output; BRCA cis rs6120849 0.754 rs6120793 chr20:33604407 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.19 0.37 1.1e-22 Protein C levels; BRCA cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg06453172 chr10:134556979 INPP5A -0.47 -11.15 -0.4 1.71e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs514406 0.708 rs536621 chr1:53309097 A/G cg27535305 chr1:53392650 SCP2 -0.47 -11.46 -0.41 9.07e-28 Monocyte count; BRCA cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg05985134 chr18:33552581 C18orf21 0.65 11.89 0.43 1.34e-29 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg02475777 chr4:1388615 CRIPAK 0.67 13.02 0.46 1.61e-34 Longevity; BRCA cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg00631329 chr6:26305371 NA -0.42 -12.61 -0.45 1.07e-32 Educational attainment; BRCA cis rs360798 0.512 rs4461246 chr2:63027671 C/T cg17519650 chr2:63277830 OTX1 -0.39 -8.4 -0.32 2.86e-16 Coronary artery disease; BRCA cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg04827223 chr11:72435913 ARAP1 -0.73 -18.35 -0.59 1.03e-60 Body mass index; BRCA cis rs2777491 0.957 rs7181911 chr15:41674060 T/C cg18705301 chr15:41695430 NDUFAF1 -0.65 -15.01 -0.51 7.38e-44 Ulcerative colitis; BRCA cis rs1059312 0.966 rs2291349 chr12:129284248 T/C cg09035930 chr12:129282057 SLC15A4 0.56 16.41 0.54 8.76e-51 Systemic lupus erythematosus; BRCA cis rs847577 0.540 rs3847055 chr7:97680645 A/G cg21770322 chr7:97807741 LMTK2 -0.38 -8.62 -0.32 5.26e-17 Breast cancer; BRCA cis rs2066819 0.892 rs112931321 chr12:56667894 C/T cg26734620 chr12:56694298 CS 0.89 10.24 0.38 6.69e-23 Psoriasis vulgaris; BRCA cis rs4268898 0.662 rs2303297 chr2:24432937 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.28 0.31 7.42e-16 Asthma; BRCA cis rs1395 0.710 rs2083363 chr2:27475318 G/C cg23587288 chr2:27483067 SLC30A3 -0.38 -8.9 -0.33 5.91e-18 Blood metabolite levels; BRCA cis rs61990749 0.544 rs3759728 chr14:78230159 A/T cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.57 0.39 3.61e-24 Fibroblast growth factor basic levels; BRCA cis rs813218 0.523 rs652026 chr3:99442809 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -9.33 -0.35 1.68e-19 Orofacial clefts; BRCA cis rs477895 0.838 rs12798333 chr11:64012784 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 11.64 0.42 1.62e-28 Mean platelet volume; BRCA cis rs1003719 0.679 rs2835674 chr21:38581522 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.01 -0.48 4.4e-39 Eye color traits; BRCA cis rs701145 0.585 rs1470664 chr3:153865193 C/T cg12800244 chr3:153838788 SGEF 0.58 8.24 0.31 9.43e-16 Coronary artery disease; BRCA cis rs3784262 0.669 rs4646555 chr15:58355345 G/A cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.65 -0.39 1.79e-24 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2421770 0.530 rs4755396 chr11:35370624 G/A cg13971030 chr11:35366721 SLC1A2 -0.44 -9.75 -0.36 5.14e-21 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg24562669 chr7:97807699 LMTK2 0.7 21.74 0.65 7.16e-79 Breast cancer; BRCA cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.72 -0.36 6.21e-21 Alzheimer's disease (late onset); BRCA trans rs11039798 1.000 rs7928243 chr11:48589192 A/T cg15704280 chr7:45808275 SEPT13 0.54 8.11 0.31 2.55e-15 Axial length; BRCA cis rs782590 0.537 rs7575170 chr2:55886780 C/T cg18811423 chr2:55921094 PNPT1 -0.51 -12.59 -0.45 1.23e-32 Metabolic syndrome; BRCA cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg07537917 chr2:241836409 C2orf54 -0.47 -11.09 -0.4 2.95e-26 Urinary metabolites; BRCA cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.47 -9.71 -0.36 7.2e-21 Bipolar disorder; BRCA cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg12756686 chr19:29218302 NA 0.59 11.07 0.4 3.69e-26 Methadone dose in opioid dependence; BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg14863265 chr7:2801509 GNA12 0.45 9.74 0.36 5.4e-21 Height; BRCA cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg07917127 chr4:99064746 C4orf37 0.45 8.19 0.31 1.38e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg17845761 chr1:175162550 KIAA0040 -0.27 -10.05 -0.37 3.53e-22 Alcohol dependence; BRCA cis rs1372520 0.766 rs2583961 chr4:90779758 A/G cg15133208 chr4:90757351 SNCA -0.4 -8.3 -0.31 6e-16 Neuroticism; BRCA cis rs1975991 0.670 rs7641501 chr3:187950157 T/C cg15417654 chr3:187959138 LPP 0.37 9.75 0.36 5.04e-21 White matter integrity (bipolar disorder risk interaction); BRCA cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg02544614 chr20:61657117 NA 0.29 8.22 0.31 1.12e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs7824557 0.606 rs1435277 chr8:11196970 C/T cg15556689 chr8:8085844 FLJ10661 0.35 9.44 0.35 6.74e-20 Retinal vascular caliber; BRCA cis rs56235845 0.694 rs12055081 chr5:176757191 C/T cg16006841 chr5:176797999 RGS14 0.6 11.82 0.42 2.78e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs7640424 0.826 rs7635063 chr3:107818777 C/T cg09227934 chr3:107805635 CD47 -0.43 -9.58 -0.35 2.16e-20 Body mass index; BRCA cis rs7258465 1.000 rs4808136 chr19:18618867 A/G cg01065977 chr19:18549689 ISYNA1 0.28 8.33 0.31 4.92e-16 Breast cancer; BRCA cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.41 -0.44 7.98e-32 Bipolar disorder; BRCA cis rs919433 0.680 rs7582536 chr2:198436103 C/T cg00792783 chr2:198669748 PLCL1 -0.39 -8.7 -0.33 2.83e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg04414720 chr1:150670196 GOLPH3L 0.36 8.16 0.31 1.82e-15 Melanoma; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg21747090 chr2:27597821 SNX17 -0.45 -9.7 -0.36 7.6e-21 Total body bone mineral density; BRCA cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg06970220 chr1:156163860 SLC25A44 0.38 9.35 0.35 1.44e-19 Testicular germ cell tumor; BRCA cis rs1506636 0.927 rs11983604 chr7:123329754 T/G cg03229431 chr7:123269106 ASB15 -0.62 -14.03 -0.49 3.46e-39 Plateletcrit;Platelet count; BRCA cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7809615 0.901 rs11761528 chr7:99118801 C/T cg12290671 chr7:99195819 NA -0.52 -8.66 -0.32 3.82e-17 Blood metabolite ratios; BRCA cis rs12142240 0.659 rs67547686 chr1:46832229 G/C cg10495392 chr1:46806563 NSUN4 0.45 8.32 0.31 5.33e-16 Menopause (age at onset); BRCA cis rs17376456 0.825 rs10079708 chr5:93261796 G/C cg25358565 chr5:93447407 FAM172A 1.16 18.42 0.59 4.3e-61 Diabetic retinopathy; BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg00106254 chr7:1943704 MAD1L1 0.42 10.22 0.37 7.92e-23 Bipolar disorder and schizophrenia; BRCA cis rs77686669 1 rs77686669 chr7:99744572 T/C cg22004693 chr7:99632812 ZKSCAN1 0.46 9.72 0.36 6.21e-21 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7103648 0.669 rs10437655 chr11:47391948 G/A cg03711944 chr11:47377212 SPI1 -0.38 -10.38 -0.38 1.89e-23 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg11301795 chr4:187892539 NA -0.25 -8.13 -0.31 2.31e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs8028182 0.609 rs8038760 chr15:75742095 A/C cg20655648 chr15:75932815 IMP3 0.4 7.81 0.3 2.38e-14 Sudden cardiac arrest; BRCA cis rs72781680 0.715 rs72796332 chr2:24142060 G/A cg08917208 chr2:24149416 ATAD2B 0.64 10.69 0.39 1.17e-24 Lymphocyte counts; BRCA cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg26408565 chr15:76604113 ETFA -0.49 -10.39 -0.38 1.79e-23 Blood metabolite levels; BRCA cis rs243505 0.898 rs243535 chr7:148410123 A/C cg09806900 chr7:148480153 CUL1 -0.42 -8.54 -0.32 1e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg18404041 chr3:52824283 ITIH1 -0.3 -8.96 -0.33 3.45e-18 Bipolar disorder; BRCA cis rs7918232 0.882 rs788237 chr10:27457932 C/T cg14442939 chr10:27389572 ANKRD26 -0.68 -10.91 -0.4 1.61e-25 Breast cancer; BRCA trans rs61931739 0.513 rs1608906 chr12:33894986 T/C cg26384229 chr12:38710491 ALG10B 0.41 9.41 0.35 8.75e-20 Morning vs. evening chronotype; BRCA cis rs6459804 1.000 rs6459804 chr7:157510195 C/T cg05731713 chr7:157510257 PTPRN2 0.39 10.14 0.37 1.62e-22 Bipolar disorder and schizophrenia; BRCA cis rs9814567 1.000 rs4334685 chr3:134304335 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg03929089 chr4:120376271 NA 0.65 12.96 0.46 2.86e-34 Coronary artery disease; BRCA cis rs68170813 0.559 rs12532967 chr7:106937418 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.55 -0.32 8.91e-17 Coronary artery disease; BRCA cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -8.98 -0.33 3.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.14 0.31 2.15e-15 Menopause (age at onset); BRCA cis rs3733585 0.699 rs4339211 chr4:9947658 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.82 -0.39 3.6e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1577917 1.000 rs12204365 chr6:86700532 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.77 -0.42 4.5e-29 Response to antipsychotic treatment; BRCA cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg26597838 chr10:835615 NA 0.95 14.86 0.51 4.14e-43 Eosinophil percentage of granulocytes; BRCA cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg11057378 chr10:81107060 PPIF 0.36 8.83 0.33 1.02e-17 Height; BRCA cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.73 11.27 0.41 5.27e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg11764359 chr7:65958608 NA 0.63 10.74 0.39 7.39e-25 Aortic root size; BRCA cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg05313129 chr8:58192883 C8orf71 -0.45 -9.24 -0.34 3.65e-19 Developmental language disorder (linguistic errors); BRCA cis rs6546550 0.901 rs7419837 chr2:70146625 T/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.84e-28 Prevalent atrial fibrillation; BRCA cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs12618769 0.597 rs72819972 chr2:99035113 A/C cg10123293 chr2:99228465 UNC50 0.4 8.07 0.3 3.59e-15 Bipolar disorder; BRCA cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 9.01 0.34 2.4e-18 Personality dimensions; BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA trans rs9858542 0.953 rs9858280 chr3:49597737 T/C cg21659725 chr3:3221576 CRBN -0.46 -10.23 -0.38 7.8e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg14784868 chr12:69753453 YEATS4 -0.51 -12.31 -0.44 2.09e-31 Blood protein levels; BRCA trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg03929089 chr4:120376271 NA 0.5 8.32 0.31 5.45e-16 Axial length; BRCA cis rs60843830 1.000 rs60149603 chr2:285421 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.63 0.59 3.21e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg23285459 chr7:2802560 GNA12 -0.36 -9.05 -0.34 1.76e-18 Height; BRCA cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.0 -0.34 2.61e-18 Developmental language disorder (linguistic errors); BRCA cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg11822812 chr5:140052017 DND1 -0.3 -8.2 -0.31 1.37e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg16339924 chr4:17578868 LAP3 0.63 15.82 0.53 8.24e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12477438 0.520 rs4340581 chr2:99725025 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.24 0.68 4.47e-87 Chronic sinus infection; BRCA cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 17.28 0.56 3.32e-55 Hip circumference adjusted for BMI; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 11.66 0.42 1.3e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg22974920 chr21:40686053 BRWD1 -0.39 -8.57 -0.32 7.84e-17 Cognitive function; BRCA cis rs16958440 0.867 rs10083937 chr18:44695602 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs2625529 0.761 rs16956444 chr15:72271235 C/T cg16672083 chr15:72433130 SENP8 -0.85 -17.83 -0.58 5.36e-58 Red blood cell count; BRCA trans rs11098499 0.863 rs3775843 chr4:120427844 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.16 0.31 1.83e-15 Corneal astigmatism; BRCA cis rs9733 0.536 rs6661415 chr1:150635869 G/A cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs6558530 0.640 rs7844748 chr8:1702343 C/T cg19131313 chr8:1704013 NA 0.4 8.27 0.31 7.97e-16 Systolic blood pressure; BRCA cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg01579765 chr21:45077557 HSF2BP -0.34 -8.86 -0.33 7.94e-18 Mean corpuscular volume; BRCA cis rs6963495 0.818 rs56165465 chr7:105180384 C/T cg19920283 chr7:105172520 RINT1 0.59 10.74 0.39 7.65e-25 Bipolar disorder (body mass index interaction); BRCA cis rs7617773 0.746 rs11713476 chr3:48375434 C/T cg11946769 chr3:48343235 NME6 0.6 12.69 0.45 4.34e-33 Coronary artery disease; BRCA cis rs7917772 0.582 rs7075269 chr10:104365724 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.69 0.5 2.7e-42 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs72781680 1.000 rs72796328 chr2:24141343 A/G cg08917208 chr2:24149416 ATAD2B 1.12 15.97 0.53 1.45e-48 Lymphocyte counts; BRCA cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg01579765 chr21:45077557 HSF2BP -0.43 -11.44 -0.41 1.04e-27 Mean corpuscular volume; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.14 -0.34 8.22e-19 Total body bone mineral density; BRCA cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg26384229 chr12:38710491 ALG10B 0.69 15.98 0.53 1.38e-48 Bladder cancer; BRCA cis rs12701220 0.847 rs10272002 chr7:1047615 A/G cg06145435 chr7:1022769 CYP2W1 0.49 9.06 0.34 1.62e-18 Bronchopulmonary dysplasia; BRCA cis rs16976116 0.855 rs7172289 chr15:55501705 A/G cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg01528321 chr10:82214614 TSPAN14 0.62 14.12 0.49 1.3e-39 Post bronchodilator FEV1; BRCA cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg15541040 chr2:3486749 NA -0.47 -10.43 -0.38 1.21e-23 Neurofibrillary tangles; BRCA cis rs793571 0.544 rs1427282 chr15:58914326 C/T cg05156742 chr15:59063176 FAM63B 0.49 9.81 0.36 2.97e-21 Schizophrenia; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03576123 chr11:487126 PTDSS2 -1.23 -18.77 -0.6 6.43e-63 Body mass index; BRCA cis rs829883 0.659 rs11109528 chr12:98951362 G/A cg25150519 chr12:98850993 NA -0.48 -8.61 -0.32 5.63e-17 Colorectal adenoma (advanced); BRCA cis rs17376456 0.825 rs6877030 chr5:93201841 C/A cg21475434 chr5:93447410 FAM172A 0.67 8.4 0.32 3e-16 Diabetic retinopathy; BRCA cis rs1832871 0.672 rs9457343 chr6:158740567 A/G cg07165851 chr6:158734300 TULP4 0.63 12.61 0.45 9.95e-33 Height; BRCA cis rs3008870 0.755 rs2065002 chr1:67487119 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.59 -12.64 -0.45 7.4e-33 Lymphocyte percentage of white cells; BRCA cis rs12579753 0.917 rs10129029 chr12:82180324 G/A cg07988820 chr12:82153109 PPFIA2 -0.48 -8.44 -0.32 2.13e-16 Resting heart rate; BRCA cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.6 12.66 0.45 6.27e-33 Lymphocyte counts; BRCA cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg22903471 chr2:27725779 GCKR -0.34 -8.07 -0.3 3.42e-15 Total body bone mineral density; BRCA cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg06453172 chr10:134556979 INPP5A -0.53 -11.49 -0.41 6.44e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.94 0.4 1.2e-25 Rheumatoid arthritis; BRCA cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg12310025 chr6:25882481 NA -0.43 -9.98 -0.37 6.86e-22 Intelligence (multi-trait analysis); BRCA cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.07 0.3 3.55e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs754466 0.580 rs10430529 chr10:79582623 C/A cg17075019 chr10:79541650 NA -0.82 -20.01 -0.62 1.63e-69 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg10523679 chr1:76189770 ACADM -0.62 -11.47 -0.41 7.97e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs503734 0.502 rs348864 chr3:100910127 T/G cg27318481 chr3:100970896 IMPG2 -0.36 -8.69 -0.33 3.04e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17854409 1.000 rs16983290 chr20:61478894 A/G cg07645718 chr20:61493192 TCFL5 -0.64 -8.78 -0.33 1.53e-17 Obesity-related traits; BRCA cis rs9859260 0.744 rs557527 chr3:195780709 G/A cg03462622 chr3:195777018 TFRC -0.38 -8.6 -0.32 6.28e-17 Mean corpuscular volume; BRCA cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg16339924 chr4:17578868 LAP3 0.6 14.62 0.5 5.83e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg23791538 chr6:167370224 RNASET2 -0.39 -9.53 -0.35 3.14e-20 Crohn's disease; BRCA cis rs933688 1.000 rs4382199 chr5:90744228 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.27 0.61 1.43e-65 Smoking behavior; BRCA cis rs832540 0.512 rs33320 chr5:56206529 C/T cg18230493 chr5:56204884 C5orf35 -0.43 -8.61 -0.32 5.77e-17 Coronary artery disease; BRCA cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg24372256 chr21:43528868 UMODL1;C21orf128 -0.58 -12.14 -0.43 1.13e-30 IgG glycosylation; BRCA trans rs8062405 1.000 rs72793811 chr16:28839392 G/A cg09719594 chr16:21412588 NA -0.35 -7.98 -0.3 6.83e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg01416388 chr22:39784598 NA 0.39 8.18 0.31 1.48e-15 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg04317338 chr11:64019027 PLCB3 0.5 8.96 0.33 3.64e-18 Mean platelet volume; BRCA cis rs13217239 0.646 rs2142685 chr6:27054497 C/T cg12292205 chr6:26970375 C6orf41 -0.56 -12.39 -0.44 9.28e-32 Schizophrenia; BRCA cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg27165867 chr14:105738592 BRF1 -0.36 -8.55 -0.32 8.79e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs72781680 0.898 rs72796171 chr2:23942667 G/C cg08917208 chr2:24149416 ATAD2B 0.9 12.66 0.45 6.34e-33 Lymphocyte counts; BRCA cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg23711669 chr6:146136114 FBXO30 -0.76 -17.6 -0.57 8.28e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs1298908 0.639 rs2993763 chr10:82033594 G/A cg01528321 chr10:82214614 TSPAN14 0.47 10.33 0.38 3.08e-23 Diabetic kidney disease; BRCA cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg18404041 chr3:52824283 ITIH1 -0.29 -8.72 -0.33 2.44e-17 Electroencephalogram traits; BRCA cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg17330251 chr7:94953956 PON1 -0.42 -8.79 -0.33 1.39e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7617773 0.746 rs4130995 chr3:48358255 C/T cg11946769 chr3:48343235 NME6 0.52 11.59 0.42 2.6e-28 Coronary artery disease; BRCA cis rs939658 0.683 rs8038464 chr15:79463036 A/T cg17916960 chr15:79447300 NA -0.39 -9.71 -0.36 7.18e-21 Refractive error; BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs853679 0.517 rs9380065 chr6:28144751 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.1 -0.31 2.84e-15 Depression; BRCA cis rs9311474 0.539 rs12489828 chr3:52567014 G/T cg17372223 chr3:52568218 NT5DC2 0.37 9.07 0.34 1.48e-18 Electroencephalogram traits; BRCA trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg11707556 chr5:10655725 ANKRD33B -0.46 -10.46 -0.38 9.76e-24 Height; BRCA cis rs921968 0.541 rs12987171 chr2:219327030 G/C cg10223061 chr2:219282414 VIL1 -0.27 -7.89 -0.3 1.36e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs6598955 0.671 rs7550997 chr1:26596080 G/A cg00852783 chr1:26633632 UBXN11 -0.46 -7.9 -0.3 1.2e-14 Obesity-related traits; BRCA cis rs1355223 0.583 rs2941057 chr11:34882220 G/A cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.42 -0.35 8.15e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs9487051 0.834 rs436880 chr6:109553069 C/T cg21918786 chr6:109611834 NA -0.33 -8.53 -0.32 1.07e-16 Reticulocyte fraction of red cells; BRCA cis rs7607369 0.714 rs2272190 chr2:219609995 G/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 6e-26 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs897080 0.515 rs698763 chr2:44573624 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.43 0.38 1.23e-23 Height; BRCA trans rs225245 0.782 rs321601 chr17:33892087 A/C cg19694781 chr19:47549865 TMEM160 0.34 8.4 0.32 2.85e-16 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs2236918 1.000 rs735943 chr1:242030151 C/T cg17736920 chr1:242011382 EXO1 -0.42 -9.47 -0.35 5.15e-20 Menopause (age at onset); BRCA cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg00750074 chr16:89608354 SPG7 -0.39 -10.36 -0.38 2.44e-23 Multiple myeloma (IgH translocation); BRCA cis rs35110281 0.782 rs9981291 chr21:45031458 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.49 0.38 7.32e-24 Mean corpuscular volume; BRCA trans rs9291683 0.546 rs13129453 chr4:10044784 T/C cg26043149 chr18:55253948 FECH 0.4 8.71 0.33 2.66e-17 Bone mineral density; BRCA cis rs1534166 0.647 rs9876158 chr3:133508300 T/C cg16414030 chr3:133502952 NA 0.34 7.89 0.3 1.28e-14 Alcohol consumption (transferrin glycosylation); BRCA cis rs10267417 0.603 rs10244374 chr7:19863170 C/T cg07541023 chr7:19748670 TWISTNB 0.48 8.52 0.32 1.13e-16 Night sleep phenotypes; BRCA cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.65 -14.27 -0.49 2.52e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs61931739 0.500 rs11053189 chr12:34433455 G/A cg06521331 chr12:34319734 NA -0.56 -10.12 -0.37 2.01e-22 Morning vs. evening chronotype; BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg03609598 chr5:56110824 MAP3K1 -0.47 -8.01 -0.3 5.4e-15 Initial pursuit acceleration; BRCA cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg26149184 chr10:133730230 NA 0.39 7.88 0.3 1.38e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs13102973 0.640 rs4864245 chr4:135882847 G/C cg14419869 chr4:135874104 NA -0.47 -9.22 -0.34 4.29e-19 Subjective well-being; BRCA cis rs6429082 0.818 rs291344 chr1:235663860 C/G cg26050004 chr1:235667680 B3GALNT2 -0.54 -12.72 -0.45 3.39e-33 Adiposity; BRCA cis rs9486719 1.000 rs34236778 chr6:96884556 C/A cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.7200000000000002e-34 Migraine;Coronary artery disease; BRCA cis rs1538970 0.781 rs10890330 chr1:45920406 G/A cg05343316 chr1:45956843 TESK2 0.67 13.45 0.47 1.73e-36 Platelet count; BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg18279126 chr7:2041391 MAD1L1 0.4 9.23 0.34 4.04e-19 Bipolar disorder and schizophrenia; BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg13126279 chr21:47581558 C21orf56 -0.5 -10.88 -0.4 2.03e-25 Testicular germ cell tumor; BRCA cis rs1865760 0.964 rs3799373 chr6:25929173 A/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.16 0.4 1.5e-26 Height; BRCA cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.7 -0.36 7.54e-21 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg15017067 chr4:17643749 FAM184B 0.32 9.44 0.35 6.58e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs67072384 1.000 rs56693670 chr11:72445143 G/T cg04827223 chr11:72435913 ARAP1 -0.69 -11.3 -0.41 3.91e-27 Alloimmunization response to red blood cell transfusion in sickle cell anemia; BRCA trans rs61931739 0.517 rs1586409 chr12:34046614 C/A cg26384229 chr12:38710491 ALG10B 0.57 12.23 0.44 4.52e-31 Morning vs. evening chronotype; BRCA cis rs61931739 0.500 rs6488224 chr12:34537205 T/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA cis rs921968 0.541 rs576901 chr2:219424364 A/G cg02176678 chr2:219576539 TTLL4 0.46 12.18 0.43 8.14e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs6598955 0.671 rs6686100 chr1:26617338 G/C cg00852783 chr1:26633632 UBXN11 -0.47 -8.21 -0.31 1.22e-15 Obesity-related traits; BRCA cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.39 -0.38 1.86e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6723226 0.806 rs2249109 chr2:32750879 G/A cg02381751 chr2:32503542 YIPF4 0.7 15.6 0.53 1.03e-46 Intelligence (multi-trait analysis); BRCA cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg03161606 chr19:29218774 NA 0.46 8.15 0.31 1.86e-15 Methadone dose in opioid dependence; BRCA trans rs11039798 0.764 rs11039929 chr11:48703289 A/G cg15704280 chr7:45808275 SEPT13 0.59 8.79 0.33 1.39e-17 Axial length; BRCA trans rs11098499 0.954 rs10005644 chr4:120298477 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs17685 0.664 rs9801113 chr7:75792031 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.74 0.36 5.35e-21 Aortic root size; BRCA cis rs11711311 1.000 rs2603789 chr3:113470479 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.73 -0.39 7.93e-25 IgG glycosylation; BRCA cis rs4730250 0.581 rs3779500 chr7:106792704 T/C cg02696742 chr7:106810147 HBP1 0.57 9.43 0.35 7.51e-20 Osteoarthritis; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg00814883 chr7:100076585 TSC22D4 -0.49 -10.48 -0.38 8.35e-24 Platelet count; BRCA cis rs826838 0.967 rs2892410 chr12:38990282 A/G cg13010199 chr12:38710504 ALG10B -0.53 -11.61 -0.42 2.11e-28 Heart rate; BRCA trans rs11165623 0.792 rs9437609 chr1:96977961 A/C cg10631902 chr5:14652156 NA -0.5 -15.22 -0.52 6.9e-45 Hip circumference;Waist circumference; BRCA cis rs2070488 0.965 rs6805386 chr3:38557921 T/C cg24069376 chr3:38537580 EXOG -0.41 -11.84 -0.42 2.16e-29 Electrocardiographic conduction measures; BRCA cis rs7592578 0.640 rs56127319 chr2:191296429 G/A cg10560079 chr2:191398806 TMEM194B -0.67 -12.33 -0.44 1.79e-31 Diastolic blood pressure; BRCA cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg09658497 chr7:2847517 GNA12 -0.45 -9.86 -0.36 1.85e-21 Height; BRCA cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs7043114 0.525 rs2274966 chr9:95155563 C/A cg14631576 chr9:95140430 CENPP -0.32 -8.07 -0.3 3.54e-15 Height; BRCA cis rs1707322 0.752 rs28719889 chr1:46202283 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.97 0.43 6.11e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1973993 0.967 rs1555543 chr1:96944797 A/C cg10631902 chr5:14652156 NA 0.51 16.2 0.54 1.02e-49 Weight; BRCA cis rs4481887 0.861 rs4644528 chr1:248472508 T/A cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg12310025 chr6:25882481 NA -0.51 -11.33 -0.41 3.01e-27 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg05313129 chr8:58192883 C8orf71 -0.44 -9.12 -0.34 9.4e-19 Developmental language disorder (linguistic errors); BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.24 0.59 3.9e-60 Platelet count; BRCA cis rs6866344 0.697 rs56159071 chr5:178127246 T/A cg03877680 chr5:178157825 ZNF354A 0.78 14.43 0.5 4.43e-41 Neutrophil percentage of white cells; BRCA cis rs881375 0.933 rs4837804 chr9:123705304 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.43 0.32 2.35e-16 Rheumatoid arthritis; BRCA cis rs6867032 0.527 rs4246752 chr5:1975575 T/A cg26168224 chr5:2018326 NA -0.51 -11.44 -0.41 1.05e-27 Gut microbiome composition (winter); BRCA cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg06115741 chr20:33292138 TP53INP2 0.4 8.78 0.33 1.48e-17 Coronary artery disease; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg05221455 chr11:829616 EFCAB4A -0.36 -8.07 -0.3 3.49e-15 Mean platelet volume; BRCA cis rs9400271 0.609 rs9386783 chr6:109588644 G/T cg21918786 chr6:109611834 NA -0.32 -8.09 -0.3 3.08e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg15017067 chr4:17643749 FAM184B 0.26 7.94 0.3 9.33e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2282335 0.507 rs2498421 chr9:71855357 A/G cg14075627 chr9:71863002 TJP2 0.38 8.85 0.33 8.61e-18 Renal sinus fat; BRCA cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg08564027 chr20:61660810 NA 0.84 22.49 0.66 5.99e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg14440974 chr22:39074834 NA 0.36 8.48 0.32 1.5e-16 Menopause (age at onset); BRCA cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs17270561 0.636 rs9393671 chr6:25789189 G/C cg17691542 chr6:26056736 HIST1H1C -0.43 -9.27 -0.34 2.89e-19 Iron status biomarkers; BRCA cis rs733592 0.507 rs7138917 chr12:48455255 G/A cg24011408 chr12:48396354 COL2A1 -0.44 -9.99 -0.37 6.05e-22 Plateletcrit; BRCA cis rs1499614 1.000 rs2659911 chr7:66158420 G/A cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs13102973 0.965 rs13142779 chr4:135872841 G/T cg14419869 chr4:135874104 NA 0.51 10.89 0.4 1.92e-25 Subjective well-being; BRCA cis rs2964802 0.505 rs4410623 chr5:10832271 A/C cg14521931 chr5:10832172 NA 0.59 13.56 0.47 5.41e-37 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs7927771 0.524 rs11039402 chr11:47826090 A/C cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Subjective well-being; BRCA cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg12310025 chr6:25882481 NA -0.48 -11.05 -0.4 4.13e-26 Intelligence (multi-trait analysis); BRCA cis rs3617 0.573 rs9825230 chr3:52901974 G/A cg11645453 chr3:52864694 ITIH4 0.34 8.39 0.31 3.15e-16 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs6723226 0.806 rs2710606 chr2:32811909 A/G cg02381751 chr2:32503542 YIPF4 0.7 14.72 0.5 1.85e-42 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg12310025 chr6:25882481 NA -0.5 -12.1 -0.43 1.71e-30 Blood metabolite levels; BRCA cis rs6964587 1.000 rs4727266 chr7:91570129 C/T cg17063962 chr7:91808500 NA -0.53 -12.46 -0.44 4.56e-32 Breast cancer; BRCA cis rs507080 0.883 rs693306 chr11:118558333 A/G cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs4727443 0.866 rs2897075 chr7:99630342 C/T cg22004693 chr7:99632812 ZKSCAN1 0.4 9.04 0.34 1.91e-18 Interstitial lung disease; BRCA cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg18230493 chr5:56204884 C5orf35 0.4 8.14 0.31 2.06e-15 Coronary artery disease; BRCA trans rs61931739 0.534 rs35056575 chr12:34142914 A/T cg13010199 chr12:38710504 ALG10B 0.49 9.47 0.35 5.13e-20 Morning vs. evening chronotype; BRCA cis rs7819412 0.521 rs2409720 chr8:11037903 A/C cg21775007 chr8:11205619 TDH -0.49 -9.88 -0.36 1.65e-21 Triglycerides; BRCA cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.3 0.49 1.81e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7408868 1.000 rs10422818 chr19:15285272 A/G cg14696996 chr19:15285081 NOTCH3 0.85 12.99 0.46 2e-34 Pulse pressure; BRCA trans rs7746199 0.673 rs72845046 chr6:27575268 T/A cg06606381 chr12:133084897 FBRSL1 -0.87 -8.53 -0.32 1.1e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg18364779 chr6:26104403 HIST1H4C -0.3 -7.82 -0.3 2.22e-14 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg11814155 chr7:99998594 ZCWPW1 0.46 8.22 0.31 1.16e-15 Platelet count; BRCA cis rs778371 0.723 rs12999865 chr2:233627250 T/C cg08000102 chr2:233561755 GIGYF2 0.85 21.14 0.64 1.29e-75 Schizophrenia; BRCA cis rs2777491 0.507 rs34040639 chr15:41760807 A/G cg18705301 chr15:41695430 NDUFAF1 -1.07 -26.66 -0.73 7.94e-106 Ulcerative colitis; BRCA cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg04450456 chr4:17643702 FAM184B -0.38 -10.19 -0.37 1.06e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg17724175 chr1:150552817 MCL1 0.25 7.91 0.3 1.15e-14 Melanoma; BRCA cis rs4237845 0.804 rs11172372 chr12:58286273 T/C cg00677455 chr12:58241039 CTDSP2 0.46 11.08 0.4 3.16e-26 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.601 rs9406160 chr6:8464907 A/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA trans rs61931739 0.534 rs1384860 chr12:34045388 T/C cg13010199 chr12:38710504 ALG10B 0.4 8.09 0.3 3.05e-15 Morning vs. evening chronotype; BRCA cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg01017244 chr2:74357527 NA 0.57 13.33 0.47 6.22e-36 Gestational age at birth (maternal effect); BRCA cis rs490234 0.702 rs12553311 chr9:128398996 T/C cg14078157 chr9:128172775 NA -0.48 -10.77 -0.39 5.52e-25 Mean arterial pressure; BRCA cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.42 -0.38 1.33e-23 Personality dimensions; BRCA cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg03146154 chr1:46216737 IPP 0.52 11.5 0.41 6.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7772486 0.754 rs4896839 chr6:146019689 T/G cg05347473 chr6:146136440 FBXO30 -0.41 -7.98 -0.3 7.05e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3858526 0.959 rs4758219 chr11:5951846 G/C cg13902645 chr11:5959945 NA -0.57 -11.54 -0.42 4e-28 DNA methylation (variation); BRCA cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.41e-39 Initial pursuit acceleration; BRCA cis rs2832077 0.943 rs11700746 chr21:30189207 T/C cg08807101 chr21:30365312 RNF160 -0.47 -7.97 -0.3 7.37e-15 Cognitive test performance; BRCA cis rs875971 0.830 rs809025 chr7:65849819 C/G cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg23711669 chr6:146136114 FBXO30 0.77 17.6 0.57 8.16e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs889312 0.500 rs702688 chr5:56190986 A/G cg24531977 chr5:56204891 C5orf35 -0.45 -9.33 -0.35 1.76e-19 Breast cancer;Breast cancer (early onset); BRCA trans rs3780486 0.846 rs73484568 chr9:33132492 G/A cg20290983 chr6:43655470 MRPS18A 1.1 40.85 0.85 2.49e-180 IgG glycosylation; BRCA cis rs1865760 0.929 rs1436307 chr6:25939723 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 9.86 0.36 1.87e-21 Height; BRCA cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg07817648 chr10:79422355 NA -0.71 -13.18 -0.46 2.81e-35 Bone mineral density; BRCA cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs6709815 0.902 rs13020432 chr2:219668211 C/T cg02176678 chr2:219576539 TTLL4 -0.36 -9.59 -0.35 1.92e-20 Reticulocyte count;High light scatter reticulocyte count; BRCA cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg00321850 chr1:175162397 KIAA0040 0.39 10.96 0.4 9.67e-26 Alcohol dependence; BRCA cis rs7617773 0.817 rs3937 chr3:48312402 T/C cg11946769 chr3:48343235 NME6 0.62 13.44 0.47 1.95e-36 Coronary artery disease; BRCA cis rs6088580 0.634 rs6579165 chr20:32994715 A/G cg24642439 chr20:33292090 TP53INP2 -0.54 -11.77 -0.42 4.23e-29 Glomerular filtration rate (creatinine); BRCA cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg22906224 chr7:99728672 NA 0.43 8.38 0.31 3.49e-16 Coronary artery disease; BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA cis rs6684514 1.000 rs12132794 chr1:156281020 C/G cg16558208 chr1:156270281 VHLL -0.36 -8.29 -0.31 6.83e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg17143192 chr8:8559678 CLDN23 0.57 11.08 0.4 3.3e-26 Obesity-related traits; BRCA cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.6 0.39 2.82e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3741404 0.791 rs11603192 chr11:63927695 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 8.49 0.32 1.49e-16 Platelet count; BRCA cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg02743256 chr7:2109353 MAD1L1 -0.45 -7.85 -0.3 1.78e-14 Bipolar disorder; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg09177884 chr7:1199841 ZFAND2A -0.59 -14.27 -0.49 2.55e-40 Longevity;Endometriosis; BRCA cis rs4713118 0.662 rs9357060 chr6:28024486 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.45e-16 Parkinson's disease; BRCA cis rs7809950 1.000 rs2712214 chr7:107188031 G/A cg23024343 chr7:107201750 COG5 -0.4 -9.3 -0.35 2.14e-19 Coronary artery disease; BRCA cis rs11190604 0.767 rs7076606 chr10:102192267 T/C cg07080220 chr10:102295463 HIF1AN 0.44 9.8 0.36 3.27e-21 Palmitoleic acid (16:1n-7) levels; BRCA trans rs208520 0.609 rs208436 chr6:66897470 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.59 -11.31 -0.41 3.7e-27 Exhaled nitric oxide output; BRCA cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -9.55 -0.35 2.62e-20 Schizophrenia; BRCA cis rs17270561 0.609 rs9356984 chr6:25725481 C/T cg17691542 chr6:26056736 HIST1H1C -0.44 -8.47 -0.32 1.72e-16 Iron status biomarkers; BRCA cis rs875971 0.522 rs781144 chr7:65440344 C/G cg11764359 chr7:65958608 NA 0.58 12.77 0.45 1.92e-33 Aortic root size; BRCA cis rs2806561 0.929 rs2867315 chr1:23541286 C/T cg19743168 chr1:23544995 NA -0.47 -11.84 -0.42 2.19e-29 Height; BRCA cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg15839431 chr19:19639596 YJEFN3 -0.39 -8.48 -0.32 1.5e-16 Bipolar disorder; BRCA cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg11752832 chr7:134001865 SLC35B4 0.52 13.41 0.47 2.76e-36 Mean platelet volume; BRCA cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg03264133 chr6:25882463 NA -0.53 -11.13 -0.4 1.93e-26 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg11644478 chr21:40555479 PSMG1 -0.52 -10.93 -0.4 1.36e-25 Menarche (age at onset); BRCA cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg00409905 chr10:38381863 ZNF37A -0.53 -11.4 -0.41 1.62e-27 Extrinsic epigenetic age acceleration; BRCA cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.71 -0.36 6.8e-21 Tonsillectomy; BRCA cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg17507749 chr15:85114479 UBE2QP1 -0.58 -10.76 -0.39 6.41e-25 Schizophrenia; BRCA cis rs2985684 0.948 rs2883437 chr14:50031666 A/G cg04989706 chr14:50066350 PPIL5 -0.47 -9.18 -0.34 5.93e-19 Carotid intima media thickness; BRCA cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg18761221 chr20:60518478 NA 0.35 8.7 0.33 2.7e-17 Obesity-related traits; BRCA cis rs6570726 0.935 rs395948 chr6:145820185 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg09184832 chr6:79620586 NA -0.52 -11.52 -0.41 5.03e-28 Intelligence (multi-trait analysis); BRCA cis rs2243480 1.000 rs160637 chr7:65584318 C/T cg18252515 chr7:66147081 NA -1.05 -15.27 -0.52 4.18e-45 Diabetic kidney disease; BRCA cis rs11030122 0.702 rs10835399 chr11:3989182 G/A cg18678763 chr11:4115507 RRM1 -0.35 -7.91 -0.3 1.1e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs4953318 0.619 rs35744969 chr2:46353140 C/A cg12428440 chr2:46370979 PRKCE 0.47 10.0 0.37 5.68e-22 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg05623727 chr3:50126028 RBM5 0.42 10.02 0.37 4.59e-22 Intelligence (multi-trait analysis); BRCA cis rs4285028 0.948 rs35415993 chr3:121669236 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.8 -0.39 4.4e-25 Multiple sclerosis; BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg13047869 chr3:10149882 C3orf24 0.52 10.84 0.39 2.92e-25 Alzheimer's disease; BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg16431978 chr21:31797932 KRTAP13-3 0.35 9.01 0.34 2.4e-18 HDL cholesterol; BRCA cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.66 0.42 1.28e-28 Mean platelet volume; BRCA cis rs698833 0.962 rs1067386 chr2:44644257 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.69 0.36 8.6e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs62380364 0.602 rs591228 chr5:88064809 G/A cg22951263 chr5:87985283 NA -0.37 -10.35 -0.38 2.7e-23 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs9457247 0.602 rs13204839 chr6:167471119 G/A cg07741184 chr6:167504864 NA 0.36 10.44 0.38 1.19e-23 Crohn's disease; BRCA cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg09877947 chr5:131593287 PDLIM4 0.34 8.43 0.32 2.29e-16 Blood metabolite levels; BRCA cis rs17023223 0.537 rs4508058 chr1:119684250 T/C cg05756136 chr1:119680316 WARS2 -0.41 -7.81 -0.3 2.31e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.67 -0.32 3.47e-17 Total body bone mineral density; BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg22920501 chr2:26401640 FAM59B -0.67 -11.5 -0.41 5.96e-28 Gut microbiome composition (summer); BRCA cis rs4660306 0.961 rs12082256 chr1:45951380 A/G cg24296786 chr1:45957014 TESK2 0.42 8.41 0.32 2.77e-16 Homocysteine levels; BRCA cis rs4319547 0.741 rs4758663 chr12:122939483 A/G cg05707623 chr12:122985044 ZCCHC8 -0.39 -7.98 -0.3 6.69e-15 Body mass index; BRCA cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs4629180 1.000 rs4629180 chr2:102088370 G/A cg04415270 chr2:102091202 RFX8 -0.33 -8.32 -0.31 5.14e-16 Chronic rhinosinusitis with nasal polyps; BRCA cis rs4642101 0.662 rs3901664 chr3:12824660 T/C cg05775895 chr3:12838266 CAND2 0.36 8.03 0.3 4.82e-15 QRS complex (12-leadsum); BRCA cis rs6429082 0.510 rs2789367 chr1:235506918 G/C cg26050004 chr1:235667680 B3GALNT2 0.33 7.99 0.3 6.1e-15 Adiposity; BRCA cis rs7246657 0.712 rs4803263 chr19:38066782 G/A cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs9814567 0.963 rs36006513 chr3:134291913 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.85e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg03213289 chr20:61660250 NA 0.61 16.17 0.54 1.49e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg24596788 chr1:163392923 NA 0.39 10.45 0.38 1.07e-23 Motion sickness; BRCA cis rs7618915 0.508 rs13065851 chr3:52644836 T/A cg18404041 chr3:52824283 ITIH1 -0.43 -12.74 -0.45 2.68e-33 Bipolar disorder; BRCA cis rs829883 1.000 rs1347956 chr12:98889564 A/G cg25150519 chr12:98850993 NA 0.59 12.03 0.43 3.29e-30 Colorectal adenoma (advanced); BRCA cis rs6665290 0.669 rs7552783 chr1:227174145 T/C cg10327440 chr1:227177885 CDC42BPA -1.05 -34.79 -0.81 1.34e-149 Myeloid white cell count; BRCA cis rs941873 0.868 rs2233718 chr10:81108956 A/G cg08514558 chr10:81106712 PPIF 0.36 8.71 0.33 2.56e-17 Height; BRCA trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.16 -0.37 1.39e-22 Intelligence (multi-trait analysis); BRCA cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg01874867 chr7:94954059 PON1 -0.39 -8.02 -0.3 4.93e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs9291683 0.527 rs11727087 chr4:10096020 A/G cg26043149 chr18:55253948 FECH 0.41 8.72 0.33 2.33e-17 Bone mineral density; BRCA trans rs11098499 0.738 rs10026493 chr4:120384194 C/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs9527 0.830 rs11191442 chr10:104643596 T/A cg04362960 chr10:104952993 NT5C2 0.48 10.54 0.38 4.79e-24 Arsenic metabolism; BRCA cis rs4423214 0.592 rs3829251 chr11:71194559 G/A cg05163923 chr11:71159392 DHCR7 -0.46 -8.05 -0.3 3.94e-15 Vitamin D levels; BRCA trans rs877282 0.898 rs12357016 chr10:765675 C/T cg22713356 chr15:30763199 NA 1.3 24.11 0.69 7.71e-92 Uric acid levels; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg07092213 chr7:1199455 ZFAND2A -0.52 -11.95 -0.43 7.75e-30 Longevity;Endometriosis; BRCA cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs897984 0.609 rs1108431 chr16:31054607 C/T cg02466173 chr16:30829666 NA -0.45 -9.98 -0.37 6.54e-22 Dementia with Lewy bodies; BRCA cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg09658497 chr7:2847517 GNA12 -0.41 -8.69 -0.33 3.03e-17 Height; BRCA cis rs7395581 0.879 rs3758673 chr11:47278917 C/T cg25783544 chr11:47291846 MADD 0.43 9.49 0.35 4.43e-20 HDL cholesterol; BRCA cis rs2282802 0.685 rs6869910 chr5:139629450 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.19 0.31 1.47e-15 Intelligence (multi-trait analysis); BRCA cis rs654351 0.543 rs622388 chr6:10387117 T/G cg17959970 chr6:10383164 NA -0.42 -8.71 -0.33 2.5e-17 Squamous cell lung carcinoma; BRCA cis rs2204008 0.606 rs6582502 chr12:38543352 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.25 -0.38 6.45e-23 Bladder cancer; BRCA cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.95 0.37 8.62e-22 Bipolar disorder; BRCA cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg11644478 chr21:40555479 PSMG1 0.73 14.51 0.5 1.99e-41 Cognitive function; BRCA cis rs9399135 0.967 rs6925424 chr6:135313948 T/A cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 8.89e-33 Red blood cell count; BRCA cis rs72848980 0.512 rs56033495 chr10:105383611 G/A cg00126946 chr10:105363258 SH3PXD2A 0.43 8.45 0.32 2.01e-16 White matter hyperintensity burden; BRCA cis rs10870270 1.000 rs10870271 chr10:133754807 A/G cg08754478 chr10:133766260 PPP2R2D 0.68 14.55 0.5 1.19e-41 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.2 22.44 0.66 1.12e-82 Platelet count; BRCA cis rs752010 0.902 rs60743712 chr1:42076629 G/A cg06885757 chr1:42089581 HIVEP3 0.25 8.92 0.33 4.86e-18 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg18279126 chr7:2041391 MAD1L1 0.38 8.26 0.31 8.52e-16 Bipolar disorder and schizophrenia; BRCA cis rs7582180 0.629 rs2164847 chr2:100958715 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.93 -0.3 9.57e-15 Intelligence (multi-trait analysis); BRCA cis rs11051970 0.879 rs2728682 chr12:32580193 G/A cg24626660 chr12:32551988 NA 0.28 7.97 0.3 7.27e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9300255 0.679 rs58809476 chr12:123724880 C/T cg00376283 chr12:123451042 ABCB9 -0.49 -10.17 -0.37 1.31e-22 Neutrophil percentage of white cells; BRCA trans rs7980799 0.905 rs4244866 chr12:33511983 G/C cg26384229 chr12:38710491 ALG10B -0.39 -8.14 -0.31 2.04e-15 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs9790314 0.663 rs1599379 chr3:160860665 A/G cg03342759 chr3:160939853 NMD3 -0.59 -13.14 -0.46 4.25e-35 Morning vs. evening chronotype; BRCA cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg04267008 chr7:1944627 MAD1L1 -0.52 -10.73 -0.39 7.91e-25 Bipolar disorder and schizophrenia; BRCA cis rs4561483 0.801 rs33649 chr16:11979608 G/C cg08843971 chr16:11963173 GSPT1 -0.53 -12.06 -0.43 2.59e-30 Testicular germ cell tumor; BRCA cis rs3892630 0.619 rs61062732 chr19:33304717 T/C cg22980127 chr19:33182716 NUDT19 0.9 20.58 0.63 1.44e-72 Red blood cell traits; BRCA cis rs9287719 0.967 rs13034061 chr2:10739651 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 13.04 0.46 1.24e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg11814155 chr7:99998594 ZCWPW1 0.49 8.85 0.33 8.6e-18 Platelet count; BRCA cis rs4908768 0.501 rs6577488 chr1:8534529 T/C cg20416874 chr1:8611966 RERE -0.29 -8.31 -0.31 5.55e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg03517284 chr6:25882590 NA -0.71 -16.41 -0.54 9.6e-51 Blood metabolite levels; BRCA cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg11764359 chr7:65958608 NA -0.63 -11.19 -0.4 1.18e-26 Aortic root size; BRCA cis rs875971 1.000 rs6945843 chr7:65734783 G/A cg18876405 chr7:65276391 NA -0.56 -13.45 -0.47 1.65e-36 Aortic root size; BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 21.43 0.65 3.48e-77 Platelet count; BRCA trans rs1997103 1.000 rs4590393 chr7:55408990 C/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg21573476 chr21:45109991 RRP1B -0.32 -8.42 -0.32 2.53e-16 Mean corpuscular volume; BRCA cis rs2836974 0.830 rs2735309 chr21:40715313 C/T cg17971929 chr21:40555470 PSMG1 0.72 15.84 0.53 6.82e-48 Cognitive function; BRCA cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg05665937 chr4:1216051 CTBP1 0.37 7.9 0.3 1.25e-14 Obesity-related traits; BRCA cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg11833968 chr6:79620685 NA -0.44 -9.67 -0.36 1.01e-20 Intelligence (multi-trait analysis); BRCA cis rs9304742 0.962 rs1044467 chr19:53452769 A/G cg24044776 chr19:53454761 ZNF816A -0.35 -7.86 -0.3 1.61e-14 Psoriasis; BRCA cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg01579765 chr21:45077557 HSF2BP -0.41 -11.34 -0.41 2.72e-27 Mean corpuscular volume; BRCA cis rs9467773 1.000 rs1884948 chr6:26567988 G/A cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.8e-21 Intelligence (multi-trait analysis); BRCA trans rs35110281 0.782 rs2051407 chr21:45079245 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.13 0.37 1.8e-22 Mean corpuscular volume; BRCA cis rs9296092 0.522 rs62405955 chr6:33527176 T/C cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs10754283 0.901 rs10922684 chr1:90117934 T/C cg21401794 chr1:90099060 LRRC8C 0.48 11.79 0.42 3.56e-29 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs875971 0.862 rs801203 chr7:66023012 A/G cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.93e-19 Lymphocyte counts; BRCA cis rs2243480 1.000 rs1723267 chr7:65473314 G/A cg18252515 chr7:66147081 NA -0.88 -12.62 -0.45 9.18e-33 Diabetic kidney disease; BRCA cis rs12477438 0.501 rs13008171 chr2:99743419 G/A cg08885076 chr2:99613938 TSGA10 0.42 9.8 0.36 3.11e-21 Chronic sinus infection; BRCA cis rs4812048 1.000 rs6070697 chr20:57599402 G/A cg14073986 chr20:57617431 SLMO2 0.49 7.91 0.3 1.13e-14 Mean platelet volume; BRCA cis rs36051895 0.664 rs10115518 chr9:5094559 T/C cg02405213 chr9:5042618 JAK2 -0.5 -8.97 -0.33 3.16e-18 Pediatric autoimmune diseases; BRCA cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.71 0.39 9.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.546 rs1863602 chr4:98909304 T/C cg05340658 chr4:99064831 C4orf37 0.57 11.18 0.4 1.25e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.57 -10.5 -0.38 6.94e-24 Renal function-related traits (BUN); BRCA cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg13319975 chr6:146136371 FBXO30 -0.61 -13.49 -0.47 1.13e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs17228212 1.000 rs17228212 chr15:67458639 A/G cg26876701 chr15:67458665 SMAD3 -0.47 -9.42 -0.35 8.33e-20 Coronary heart disease; BRCA cis rs3806843 0.966 rs1030166 chr5:140185473 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.74 -0.36 5.32e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs734999 0.967 rs10752745 chr1:2507938 A/G cg20673091 chr1:2541236 MMEL1 0.32 8.41 0.32 2.64e-16 Ulcerative colitis; BRCA cis rs826838 0.967 rs1486345 chr12:39131677 G/A cg13010199 chr12:38710504 ALG10B -0.44 -10.25 -0.38 6.17e-23 Heart rate; BRCA cis rs7618915 0.571 rs7623199 chr3:52605974 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.82 0.36 2.79e-21 Bipolar disorder; BRCA cis rs1712517 0.844 rs1163081 chr10:105029840 G/C cg05636881 chr10:105038444 INA 0.36 8.17 0.31 1.68e-15 Migraine; BRCA cis rs2011503 1.000 rs4808970 chr19:19651140 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.11 -0.34 1.06e-18 Bipolar disorder; BRCA cis rs2576037 0.526 rs9304340 chr18:44526582 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 11.78 0.42 4.18e-29 Personality dimensions; BRCA cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg24229701 chr12:130821962 PIWIL1 0.39 8.89 0.33 6.08e-18 Menopause (age at onset); BRCA cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg11887960 chr12:57824829 NA 0.55 8.55 0.32 9.38e-17 Lung disease severity in cystic fibrosis; BRCA cis rs7246657 0.653 rs10402050 chr19:37688958 A/T cg23950597 chr19:37808831 NA -0.66 -10.13 -0.37 1.89e-22 Coronary artery calcification; BRCA cis rs7772486 0.790 rs6924159 chr6:146267873 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -7.84 -0.3 1.83e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.736 rs12704084 chr7:148915050 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.4 8.39 0.31 3.14e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs730566 1.000 rs4858819 chr3:48478088 C/T cg07636037 chr3:49044803 WDR6 -0.54 -10.22 -0.37 8.24e-23 Prion diseases; BRCA cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -9.16 -0.34 6.77e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg05234568 chr11:5960015 NA -0.48 -9.35 -0.35 1.49e-19 DNA methylation (variation); BRCA cis rs12200560 0.505 rs2387378 chr6:97077504 C/A cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs514406 0.929 rs564273 chr1:53332445 G/C cg25767906 chr1:53392781 SCP2 -0.38 -8.46 -0.32 1.87e-16 Monocyte count; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.89 -16.69 -0.55 3.76e-52 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 8.24 0.31 9.64e-16 Schizophrenia; BRCA cis rs9287719 0.649 rs9973374 chr2:10716384 C/T cg00105475 chr2:10696890 NA 0.41 9.15 0.34 7.77e-19 Prostate cancer; BRCA cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg03146154 chr1:46216737 IPP 0.45 10.06 0.37 3.5e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35740288 0.539 rs11634553 chr15:86336611 G/A cg20737812 chr15:86336631 KLHL25 -0.4 -9.88 -0.36 1.63e-21 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs7927592 0.913 rs4084149 chr11:68288567 A/G cg20283391 chr11:68216788 NA -0.48 -9.32 -0.35 1.88e-19 Total body bone mineral density; BRCA cis rs832540 0.552 rs702681 chr5:56218029 C/T cg18230493 chr5:56204884 C5orf35 -0.43 -8.75 -0.33 1.84e-17 Coronary artery disease; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 10.29 0.38 4.23e-23 Longevity;Endometriosis; BRCA cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg18230493 chr5:56204884 C5orf35 0.59 12.19 0.43 7.16e-31 Initial pursuit acceleration; BRCA cis rs2243480 1.000 rs410128 chr7:65603173 C/T cg18252515 chr7:66147081 NA -1.05 -14.82 -0.51 6.25e-43 Diabetic kidney disease; BRCA cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg06238570 chr21:40685208 BRWD1 -0.45 -8.93 -0.33 4.63e-18 Cognitive function; BRCA trans rs208520 0.565 rs1385222 chr6:66753013 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 27.48 0.74 2.41e-110 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4742903 0.935 rs17237053 chr9:106946359 C/T cg14250997 chr9:106856677 SMC2 -0.3 -9.18 -0.34 5.7e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7833986 1.000 rs34404111 chr8:57099190 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.27 0.31 8.08e-16 Height; BRCA cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg04166393 chr7:2884313 GNA12 0.57 12.23 0.44 4.82e-31 Height; BRCA cis rs6942756 1.000 rs6949950 chr7:128914818 G/A cg02491457 chr7:128862824 NA -0.7 -13.73 -0.48 8.68e-38 White matter hyperintensity burden; BRCA cis rs13033859 0.526 rs12477065 chr2:292753 C/T cg12623918 chr2:306882 NA 0.38 8.43 0.32 2.22e-16 Mitochondrial DNA levels; BRCA cis rs16854884 0.837 rs4362712 chr3:143801076 G/A cg06585982 chr3:143692056 C3orf58 0.4 7.98 0.3 6.7e-15 Economic and political preferences (feminism/equality); BRCA cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg05234568 chr11:5960015 NA -0.49 -9.72 -0.36 6.44e-21 DNA methylation (variation); BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 9.05 0.34 1.66e-18 Platelet count; BRCA cis rs11711311 0.868 rs13091621 chr3:113481977 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -10.82 -0.39 3.48e-25 IgG glycosylation; BRCA cis rs11711311 1.000 rs12637066 chr3:113527574 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.58 0.39 3.22e-24 IgG glycosylation; BRCA cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA cis rs13108904 0.870 rs3755924 chr4:1238363 A/G cg05665937 chr4:1216051 CTBP1 0.38 7.9 0.3 1.22e-14 Obesity-related traits; BRCA cis rs7766436 0.848 rs6903685 chr6:22605813 C/T cg13666174 chr6:22585274 NA -0.42 -9.09 -0.34 1.2e-18 Coronary artery disease; BRCA cis rs6714710 0.603 rs17489454 chr2:98407350 C/T cg26665480 chr2:98280029 ACTR1B 0.57 13.15 0.46 3.98e-35 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg12311346 chr5:56204834 C5orf35 -0.78 -14.9 -0.51 2.57e-43 Initial pursuit acceleration; BRCA trans rs35110281 0.667 rs4819285 chr21:45118970 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.39 -8.48 -0.32 1.52e-16 Mean corpuscular volume; BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg14863265 chr7:2801509 GNA12 -0.39 -8.66 -0.32 3.87e-17 Height; BRCA cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs887829 0.570 rs7608175 chr2:234599089 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.34 8.53 0.32 1.09e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA trans rs9858542 0.953 rs1987628 chr3:49399259 G/A cg21659725 chr3:3221576 CRBN -0.45 -9.78 -0.36 3.79e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2204008 0.660 rs2874343 chr12:38239096 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.83e-22 Bladder cancer; BRCA cis rs7523273 0.606 rs1830764 chr1:207917052 G/A cg22525895 chr1:207977042 MIR29B2 0.47 12.1 0.43 1.7e-30 Schizophrenia; BRCA cis rs1865760 0.622 rs9295685 chr6:26071725 G/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.43 0.41 1.17e-27 Height; BRCA cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg06064525 chr11:970664 AP2A2 -0.47 -15.55 -0.52 1.73e-46 Alzheimer's disease (late onset); BRCA trans rs783540 0.867 rs11855735 chr15:83296545 A/T cg18393722 chr15:85113863 UBE2QP1 0.28 8.87 0.33 7.07e-18 Schizophrenia; BRCA cis rs1005277 0.579 rs2474569 chr10:38383491 C/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.92 -0.56 2.46e-53 Extrinsic epigenetic age acceleration; BRCA cis rs1420338 0.967 rs1014581 chr7:34164677 T/G cg01275685 chr7:34179230 BMPER -0.46 -10.25 -0.38 6.33e-23 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs10193935 0.901 rs62142561 chr2:42477808 G/C cg27598129 chr2:42591480 NA -0.95 -14.83 -0.51 5.82e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs17641971 0.684 rs7005693 chr8:49987965 A/C cg00325661 chr8:49890786 NA 0.38 10.73 0.39 8.31e-25 Blood metabolite levels; BRCA cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg20203395 chr5:56204925 C5orf35 0.42 9.37 0.35 1.26e-19 Initial pursuit acceleration; BRCA cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg04727924 chr7:799746 HEATR2 -0.55 -10.81 -0.39 3.81e-25 Cerebrospinal P-tau181p levels; BRCA cis rs829880 1.000 rs829880 chr12:98845331 G/T cg25150519 chr12:98850993 NA 0.63 14.01 0.48 4.42e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs7727544 0.684 rs272874 chr5:131675046 A/G cg24060327 chr5:131705240 SLC22A5 0.41 8.08 0.3 3.27e-15 Blood metabolite levels; BRCA cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg23711669 chr6:146136114 FBXO30 0.71 16.42 0.54 8.37e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 8.97 0.33 3.36e-18 Personality dimensions; BRCA cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg24110177 chr3:50126178 RBM5 0.37 10.12 0.37 1.97e-22 Intelligence (multi-trait analysis); BRCA cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg26384229 chr12:38710491 ALG10B 0.76 16.95 0.56 1.8e-53 Bladder cancer; BRCA cis rs4689388 0.824 rs114669221 chr4:6301459 G/A cg00701064 chr4:6280414 WFS1 0.7 18.05 0.58 3.57e-59 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg26314531 chr2:26401878 FAM59B -0.64 -10.91 -0.4 1.59e-25 Gut microbiome composition (summer); BRCA cis rs36051895 0.664 rs3780370 chr9:5095167 A/C cg02405213 chr9:5042618 JAK2 -0.51 -9.23 -0.34 4.03e-19 Pediatric autoimmune diseases; BRCA cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg18016565 chr1:150552671 MCL1 -0.35 -8.19 -0.31 1.41e-15 Melanoma; BRCA cis rs9341808 0.718 rs9448898 chr6:80845341 T/A cg08355045 chr6:80787529 NA 0.37 9.44 0.35 6.76e-20 Sitting height ratio; BRCA trans rs17685 0.849 rs3815455 chr7:75611756 C/T cg19862616 chr7:65841803 NCRNA00174 0.56 14.11 0.49 1.53e-39 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs73086581 1.000 rs6052220 chr20:3970594 C/T cg02187196 chr20:3869020 PANK2 0.51 9.69 0.36 8.4e-21 Response to antidepressants in depression; BRCA cis rs758324 0.947 rs253943 chr5:131320730 C/T cg06307176 chr5:131281290 NA 0.52 10.5 0.38 6.5e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 11.04 0.4 4.6e-26 Platelet count; BRCA cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg23711669 chr6:146136114 FBXO30 -0.79 -18.87 -0.6 1.77e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs10771431 0.817 rs17202253 chr12:9361850 A/G cg08997352 chr12:9597637 DDX12 -0.56 -11.25 -0.41 6.44e-27 Breast size; BRCA cis rs17253792 0.822 rs10142497 chr14:56047948 C/T cg24579896 chr14:56047964 C14orf33;KTN1 -0.59 -8.32 -0.31 5.42e-16 Putamen volume; BRCA cis rs17401966 0.540 rs1536262 chr1:10438687 C/T cg03954927 chr1:10346856 KIF1B 0.34 10.19 0.37 1.09e-22 Hepatocellular carcinoma; BRCA cis rs6977660 0.505 rs9639338 chr7:19869778 T/A cg07541023 chr7:19748670 TWISTNB 0.47 8.52 0.32 1.11e-16 Thyroid stimulating hormone; BRCA cis rs7647973 0.626 rs1996664 chr3:49878395 A/G cg07636037 chr3:49044803 WDR6 -0.5 -8.3 -0.31 6.25e-16 Menarche (age at onset); BRCA cis rs4713118 0.868 rs10484401 chr6:27746590 A/T cg20933634 chr6:27740509 NA -0.44 -8.17 -0.31 1.7e-15 Parkinson's disease; BRCA trans rs7824557 0.806 rs6601573 chr8:11094751 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -9.4 -0.35 9.62e-20 Retinal vascular caliber; BRCA trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg15934090 chr1:100435551 SLC35A3 0.35 7.91 0.3 1.11e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg13175981 chr1:150552382 MCL1 0.41 9.02 0.34 2.14e-18 Tonsillectomy; BRCA cis rs9341808 0.718 rs9359408 chr6:80820132 T/G cg08355045 chr6:80787529 NA 0.37 9.38 0.35 1.13e-19 Sitting height ratio; BRCA cis rs67478160 0.619 rs10083367 chr14:104314183 C/G cg01849466 chr14:104193079 ZFYVE21 0.43 11.0 0.4 6.62e-26 Schizophrenia; BRCA cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.96 13.48 0.47 1.21e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9316337 0.902 rs12430301 chr13:21970729 C/T cg21011702 chr13:21951294 ZDHHC20 -0.31 -8.01 -0.3 5.44e-15 Schizophrenia; BRCA cis rs3820928 0.874 rs10195072 chr2:227794452 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -8.96 -0.33 3.4e-18 Pulmonary function; BRCA cis rs7809950 0.530 rs111865019 chr7:106812246 A/G cg23024343 chr7:107201750 COG5 -0.42 -8.36 -0.31 4.07e-16 Coronary artery disease; BRCA cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg15049968 chr18:44337910 ST8SIA5 -0.27 -7.89 -0.3 1.3e-14 Personality dimensions; BRCA cis rs7659604 0.628 rs3828485 chr4:122722368 G/A cg06713675 chr4:122721982 EXOSC9 -0.54 -12.52 -0.44 2.59e-32 Type 2 diabetes; BRCA cis rs514406 0.505 rs437954 chr1:53173321 C/G cg16325326 chr1:53192061 ZYG11B 0.9 24.9 0.7 3.35e-96 Monocyte count; BRCA cis rs6964587 0.967 rs4626516 chr7:91807153 G/C cg22117172 chr7:91764530 CYP51A1 0.24 8.22 0.31 1.13e-15 Breast cancer; BRCA cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg14664628 chr15:75095509 CSK -0.52 -12.37 -0.44 1.2e-31 Breast cancer; BRCA cis rs7666738 0.830 rs28515641 chr4:98726419 G/A cg05340658 chr4:99064831 C4orf37 0.63 15.15 0.51 1.51e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs61931739 0.500 rs11053268 chr12:34545121 T/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg00814883 chr7:100076585 TSC22D4 -0.54 -11.48 -0.41 7.18e-28 Platelet count; BRCA cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.4 -0.32 2.96e-16 Monocyte percentage of white cells; BRCA trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -11.44 -0.41 1.07e-27 Neuroticism; BRCA cis rs367943 0.637 rs10039956 chr5:113010928 G/A cg12552261 chr5:112820674 MCC 0.39 8.11 0.31 2.53e-15 Type 2 diabetes; BRCA cis rs8180040 0.966 rs56351005 chr3:47430186 G/T cg16586182 chr3:47516702 SCAP 0.65 15.12 0.51 2.23e-44 Colorectal cancer; BRCA cis rs8016982 0.698 rs8011097 chr14:81702736 T/C cg01989461 chr14:81687754 GTF2A1 0.61 14.29 0.49 2.22e-40 Schizophrenia; BRCA cis rs992157 0.735 rs13392177 chr2:219112956 C/T cg00012203 chr2:219082015 ARPC2 -0.72 -16.39 -0.54 1.19e-50 Colorectal cancer; BRCA cis rs10174077 0.874 rs11892439 chr2:152469858 T/A cg06191203 chr2:152266755 RIF1 -0.35 -10.13 -0.37 1.8e-22 Squamous cell lung carcinoma; BRCA trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.06 -0.56 4.9e-54 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.27 0.38 5.16e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs68170813 0.559 rs3779498 chr7:106923158 C/G cg02696742 chr7:106810147 HBP1 -0.52 -8.57 -0.32 7.9e-17 Coronary artery disease; BRCA cis rs2549003 1.000 rs2548999 chr5:131831058 G/T cg21138405 chr5:131827807 IRF1 -0.38 -12.61 -0.45 1.03e-32 Asthma (sex interaction); BRCA cis rs3760982 0.585 rs11083724 chr19:44298988 A/G cg12072164 chr19:44306565 LYPD5 0.37 8.71 0.33 2.57e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs7394190 0.748 rs3843939 chr10:75578948 T/C cg07699608 chr10:75541558 CHCHD1 0.68 9.91 0.36 1.24e-21 Incident atrial fibrillation; BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg08470875 chr2:26401718 FAM59B 0.76 11.85 0.42 2.09e-29 Gut microbiome composition (summer); BRCA cis rs6484504 0.532 rs7117286 chr11:31283810 T/A cg06552810 chr11:31128660 NA -0.38 -8.86 -0.33 8.13e-18 Red blood cell count; BRCA cis rs6429082 0.633 rs1416473 chr1:235563259 C/T cg26050004 chr1:235667680 B3GALNT2 -0.54 -12.3 -0.44 2.42e-31 Adiposity; BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.62 -13.37 -0.47 3.83e-36 Lymphocyte counts; BRCA cis rs1843834 0.539 rs1494109 chr2:225441833 G/A cg12698349 chr2:225449008 CUL3 0.61 13.03 0.46 1.44e-34 IgE levels in asthmatics (D.p. specific); BRCA cis rs1372520 0.684 rs2572318 chr4:90718719 C/T cg15133208 chr4:90757351 SNCA -0.39 -7.9 -0.3 1.21e-14 Neuroticism; BRCA cis rs66573146 0.572 rs67252699 chr4:6946411 A/G cg00086871 chr4:6988644 TBC1D14 0.77 11.86 0.42 1.9e-29 Granulocyte percentage of myeloid white cells; BRCA cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg21427119 chr20:30132790 HM13 -0.41 -8.58 -0.32 7.24e-17 Mean corpuscular hemoglobin; BRCA cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg05868516 chr6:26286170 HIST1H4H 0.41 8.07 0.3 3.49e-15 Educational attainment; BRCA cis rs10129255 0.556 rs6576222 chr14:107184681 G/A cg07958169 chr14:107095056 NA -0.39 -8.41 -0.32 2.66e-16 Kawasaki disease; BRCA cis rs28735056 0.592 rs12455965 chr18:77688830 G/C cg20368463 chr18:77673604 PQLC1 -0.51 -12.75 -0.45 2.41e-33 Schizophrenia; BRCA cis rs7582180 0.629 rs4851295 chr2:100945605 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA cis rs694739 0.628 rs11606081 chr11:64137875 T/C cg23796481 chr11:64053134 BAD;GPR137 0.51 10.65 0.39 1.78e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs3767633 0.925 rs10737502 chr1:161792321 G/A cg09175582 chr1:161736000 ATF6 0.52 8.73 0.33 2.19e-17 IgG glycosylation; BRCA cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg08917208 chr2:24149416 ATAD2B 0.93 13.79 0.48 4.73e-38 Lymphocyte counts; BRCA cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.683 rs81598 chr5:131587960 C/G cg11843238 chr5:131593191 PDLIM4 0.38 9.3 0.35 2.17e-19 Acylcarnitine levels; BRCA cis rs7666738 0.830 rs10034330 chr4:99064849 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.43 0.57 5.62e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6831352 0.691 rs2602887 chr4:100041473 A/G cg13256891 chr4:100009986 ADH5 0.48 8.83 0.33 1.01e-17 Alcohol dependence; BRCA cis rs10463316 0.817 rs6879238 chr5:150820574 G/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.63 -0.32 5e-17 Metabolite levels (Pyroglutamine); BRCA cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg13319975 chr6:146136371 FBXO30 0.34 7.86 0.3 1.67e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.29 -0.34 2.39e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs3780486 0.505 rs1411609 chr9:33137303 C/T cg04842962 chr6:43655489 MRPS18A 0.87 23.31 0.68 1.89e-87 IgG glycosylation; BRCA cis rs11098499 0.754 rs10213554 chr4:120260785 A/G cg09307838 chr4:120376055 NA -0.62 -13.07 -0.46 8.81e-35 Corneal astigmatism; BRCA cis rs73001065 0.591 rs2285626 chr19:19467545 C/T cg03709012 chr19:19516395 GATAD2A 0.84 13.58 0.47 4.3e-37 LDL cholesterol; BRCA cis rs6121246 0.609 rs6060627 chr20:30262159 C/T cg13852791 chr20:30311386 BCL2L1 0.89 20.1 0.62 5.13e-70 Mean corpuscular hemoglobin; BRCA cis rs8103278 1.000 rs8102876 chr19:46332842 C/T cg20908204 chr19:46285434 DMPK -0.27 -7.99 -0.3 6.54e-15 Coronary artery disease; BRCA cis rs2806561 0.704 rs663942 chr1:23522476 G/A cg19743168 chr1:23544995 NA 0.35 8.26 0.31 8.24e-16 Height; BRCA cis rs9527 0.615 rs17725614 chr10:104685493 G/C cg04362960 chr10:104952993 NT5C2 0.45 10.35 0.38 2.67e-23 Arsenic metabolism; BRCA cis rs9287719 0.967 rs728134 chr2:10745187 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.07 -0.3 3.46e-15 Prostate cancer; BRCA cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg18305652 chr10:134549665 INPP5A 0.51 13.36 0.47 4.37e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs17401966 0.931 rs2276100 chr1:10394536 C/G cg19773385 chr1:10388646 KIF1B -0.39 -8.51 -0.32 1.19e-16 Hepatocellular carcinoma; BRCA cis rs672059 1.000 rs672119 chr1:183162506 G/A ch.1.3577855R chr1:183094577 LAMC1 0.38 8.67 0.32 3.46e-17 Hypertriglyceridemia; BRCA cis rs3768617 0.706 rs8179460 chr1:183056222 T/C ch.1.3577855R chr1:183094577 LAMC1 0.49 11.32 0.41 3.29e-27 Fuchs's corneal dystrophy; BRCA trans rs3733585 0.699 rs7658170 chr4:9966593 C/T cg26043149 chr18:55253948 FECH 0.36 7.86 0.3 1.65e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg23285459 chr7:2802560 GNA12 -0.32 -8.44 -0.32 2.08e-16 Height; BRCA trans rs11098499 0.863 rs11723090 chr4:120490592 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.35 0.31 4.21e-16 Corneal astigmatism; BRCA cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.34 -0.44 1.56e-31 Lymphocyte counts; BRCA cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg18876405 chr7:65276391 NA 0.55 13.18 0.46 3.03e-35 Aortic root size; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg08805041 chr16:621841 PIGQ -0.32 -8.82 -0.33 1.11e-17 Height; BRCA cis rs4466137 0.904 rs6887104 chr5:83003535 G/A cg15083037 chr5:83017644 HAPLN1 -0.53 -10.72 -0.39 9.1e-25 Prostate cancer; BRCA cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg04414720 chr1:150670196 GOLPH3L 0.36 8.07 0.3 3.38e-15 Tonsillectomy; BRCA cis rs7020830 0.898 rs7846747 chr9:37167539 A/C cg14294708 chr9:37120828 ZCCHC7 1.16 39.52 0.84 9.82e-174 Schizophrenia; BRCA cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.4 -11.44 -0.41 1.08e-27 Monocyte percentage of white cells; BRCA cis rs897080 0.515 rs1065784 chr2:44660777 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.45 8.09 0.3 2.93e-15 Height; BRCA cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg06671706 chr8:8559999 CLDN23 0.43 8.38 0.31 3.48e-16 Obesity-related traits; BRCA cis rs4927850 0.918 rs4361313 chr3:195752260 A/G cg12923728 chr3:195709715 SDHAP1 -0.58 -12.42 -0.44 7.35e-32 Pancreatic cancer; BRCA cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg12935359 chr14:103987150 CKB 0.64 15.01 0.51 7.3e-44 Intelligence (multi-trait analysis); BRCA cis rs798554 0.679 rs798499 chr7:2792013 G/A cg13628971 chr7:2884303 GNA12 0.4 8.82 0.33 1.06e-17 Height; BRCA cis rs2731664 0.792 rs335452 chr5:176879671 C/T cg23176889 chr5:176863531 GRK6 -0.62 -16.86 -0.55 5.01e-53 Intelligence (multi-trait analysis); BRCA cis rs10267417 0.603 rs4543442 chr7:19911140 G/A cg05791153 chr7:19748676 TWISTNB 0.47 8.98 0.33 3.07e-18 Night sleep phenotypes; BRCA cis rs6840360 0.571 rs7664663 chr4:152508014 G/C cg22705602 chr4:152727874 NA -0.31 -7.81 -0.3 2.29e-14 Intelligence (multi-trait analysis); BRCA cis rs72781680 1.000 rs72796326 chr2:24137047 G/A cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.42e-39 Lymphocyte counts; BRCA cis rs752010 0.630 rs11210507 chr1:42105488 T/C cg06885757 chr1:42089581 HIVEP3 0.23 8.36 0.31 3.94e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg00071950 chr4:10020882 SLC2A9 -0.46 -10.89 -0.4 1.84e-25 Bone mineral density; BRCA cis rs35306767 0.903 rs12764024 chr10:922861 A/G cg26597838 chr10:835615 NA 0.93 17.43 0.57 5.99e-56 Eosinophil percentage of granulocytes; BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg17414380 chr19:19431394 KIAA0892;SF4 0.42 8.67 0.32 3.6e-17 Tonsillectomy; BRCA cis rs897080 0.589 rs1085448 chr2:44663805 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.4 0.32 2.9e-16 Height; BRCA cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg24642439 chr20:33292090 TP53INP2 -0.53 -11.48 -0.41 7.35e-28 Glomerular filtration rate (creatinine); BRCA cis rs9858542 0.953 rs7648841 chr3:49416825 G/A cg03060546 chr3:49711283 APEH -0.5 -10.14 -0.37 1.74e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9287719 0.934 rs10201077 chr2:10752426 A/C cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA trans rs8002861 0.641 rs6561148 chr13:44426269 C/T cg12856521 chr11:46389249 DGKZ 0.4 8.63 0.32 4.82e-17 Leprosy; BRCA cis rs9868809 0.764 rs2633958 chr3:48635432 A/G cg00383909 chr3:49044727 WDR6 -0.75 -9.37 -0.35 1.28e-19 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg11502198 chr6:26597334 ABT1 0.58 12.57 0.45 1.47e-32 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs6840669 chr4:99016020 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg21770322 chr7:97807741 LMTK2 0.45 11.89 0.43 1.42e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6580649 0.941 rs72644841 chr12:48411987 A/G cg05342945 chr12:48394962 COL2A1 0.47 9.25 0.34 3.2e-19 Lung cancer; BRCA cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg07952391 chr2:88470173 THNSL2 0.67 9.26 0.34 3.04e-19 Plasma clusterin levels; BRCA cis rs7481584 0.624 rs693687 chr11:3052494 A/G cg08508325 chr11:3079039 CARS 0.28 8.41 0.32 2.73e-16 Calcium levels; BRCA cis rs2625529 0.526 rs8031386 chr15:72508799 C/A cg16672083 chr15:72433130 SENP8 -0.69 -15.73 -0.53 2.21e-47 Red blood cell count; BRCA cis rs6831352 1.000 rs1126670 chr4:100052733 C/A cg12011299 chr4:100065546 ADH4 0.53 12.95 0.46 3.03e-34 Alcohol dependence; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.99 -0.3 6.12e-15 Total body bone mineral density; BRCA cis rs8114671 0.647 rs1415771 chr20:33734493 G/A cg24642439 chr20:33292090 TP53INP2 0.4 8.6 0.32 5.93e-17 Height; BRCA cis rs733175 0.857 rs3796838 chr4:10011030 C/T cg00071950 chr4:10020882 SLC2A9 0.4 7.91 0.3 1.14e-14 Psychosis and Alzheimer's disease; BRCA cis rs208520 0.955 rs9345808 chr6:67008262 C/T cg07460842 chr6:66804631 NA 0.71 11.57 0.42 2.96e-28 Exhaled nitric oxide output; BRCA cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.0 0.48 4.8e-39 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg08085267 chr17:45401833 C17orf57 -0.57 -11.12 -0.4 2.31e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg03713592 chr11:72463424 ARAP1 0.69 12.43 0.44 6.21e-32 Type 2 diabetes; BRCA cis rs2075371 1.000 rs2241334 chr7:133979225 C/G cg20476274 chr7:133979776 SLC35B4 0.69 21.34 0.65 1.01e-76 Mean platelet volume; BRCA trans rs783540 0.592 rs2567632 chr15:83284804 A/G cg16105309 chr15:79090380 ADAMTS7 0.34 9.46 0.35 5.56e-20 Schizophrenia; BRCA cis rs7639513 0.767 rs2348201 chr3:12711696 A/G cg23032965 chr3:12705835 RAF1 0.69 15.09 0.51 3.2e-44 Itch intensity from mosquito bite; BRCA cis rs703842 1.000 rs2072052 chr12:58146719 A/C cg04478727 chr12:58166393 METTL1;FAM119B 0.59 11.46 0.41 8.88e-28 Multiple sclerosis; BRCA trans rs4650994 0.544 rs10798613 chr1:178500022 C/T cg05059571 chr16:84539110 KIAA1609 -0.57 -12.59 -0.45 1.2e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs858239 0.511 rs10256996 chr7:23145295 G/T cg23682824 chr7:23144976 KLHL7 -0.34 -9.17 -0.34 6.41e-19 Cerebrospinal fluid biomarker levels; BRCA trans rs9325144 0.555 rs1813392 chr12:38692203 C/T cg23762105 chr12:34175262 ALG10 0.38 9.32 0.35 1.79e-19 Morning vs. evening chronotype; BRCA cis rs2762353 0.845 rs35720558 chr6:25784800 A/C cg03517284 chr6:25882590 NA 0.48 10.73 0.39 7.9e-25 Blood metabolite levels; BRCA cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg16506815 chr2:162101123 NA 0.51 10.97 0.4 9.04e-26 Intelligence (multi-trait analysis); BRCA cis rs1865721 0.771 rs8093397 chr18:73136217 C/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.64 -0.39 1.88e-24 Intelligence; BRCA cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs7617773 0.743 rs4632568 chr3:48367819 C/T cg11946769 chr3:48343235 NME6 0.67 13.59 0.47 3.81e-37 Coronary artery disease; BRCA cis rs11122272 0.705 rs2486742 chr1:231507254 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -12.3 -0.44 2.33e-31 Hemoglobin concentration; BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.82 -0.3 2.2e-14 Total body bone mineral density; BRCA cis rs10464366 0.957 rs6979210 chr7:39104119 C/G cg15212455 chr7:39170539 POU6F2 0.36 7.87 0.3 1.48e-14 IgG glycosylation; BRCA cis rs6460942 0.915 rs62447641 chr7:12488764 G/A cg20607287 chr7:12443886 VWDE -0.58 -8.24 -0.31 9.93e-16 Coronary artery disease; BRCA cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg05868516 chr6:26286170 HIST1H4H 0.43 8.27 0.31 7.84e-16 Educational attainment; BRCA cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs3008870 0.755 rs4655661 chr1:67408828 A/C cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.13 0.49 1.18e-39 Lymphocyte percentage of white cells; BRCA cis rs7264396 0.790 rs1040695 chr20:34244829 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.39 8.31 0.31 5.95e-16 Total cholesterol levels; BRCA cis rs7727544 0.716 rs7701414 chr5:131585958 A/G cg14196790 chr5:131705035 SLC22A5 0.4 10.24 0.38 6.84e-23 Blood metabolite levels; BRCA cis rs7904368 0.568 rs10752061 chr10:16853900 A/G cg23933602 chr10:16859644 RSU1 0.69 16.39 0.54 1.21e-50 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7945705 0.712 rs61876274 chr11:9019190 A/T cg21881798 chr11:8931708 C11orf17;ST5 0.52 11.32 0.41 3.26e-27 Hemoglobin concentration; BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg14004847 chr7:1930337 MAD1L1 -0.42 -8.34 -0.31 4.57e-16 Schizophrenia; BRCA cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg22875332 chr1:76189707 ACADM 0.66 14.31 0.49 1.74e-40 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4660306 1.000 rs2993259 chr1:46001550 T/C cg24296786 chr1:45957014 TESK2 0.44 8.86 0.33 8e-18 Homocysteine levels; BRCA cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg13256891 chr4:100009986 ADH5 0.51 10.52 0.38 5.7e-24 Alcohol dependence; BRCA cis rs2836950 0.545 rs11700813 chr21:40517469 T/G cg06238570 chr21:40685208 BRWD1 -0.41 -8.15 -0.31 1.93e-15 Menarche (age at onset); BRCA trans rs61931739 0.500 rs9669027 chr12:34583528 C/T cg26384229 chr12:38710491 ALG10B -0.61 -13.88 -0.48 1.75e-38 Morning vs. evening chronotype; BRCA cis rs3749237 0.964 rs35210174 chr3:49812606 C/T cg07636037 chr3:49044803 WDR6 0.43 8.7 0.33 2.85e-17 Resting heart rate; BRCA cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg05347473 chr6:146136440 FBXO30 -0.43 -8.76 -0.33 1.79e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg02079420 chr8:82753780 SNX16 0.36 8.09 0.3 2.91e-15 Diastolic blood pressure; BRCA cis rs12950390 0.853 rs12450729 chr17:45855363 A/G cg24803719 chr17:45855879 NA -0.31 -8.1 -0.31 2.77e-15 IgG glycosylation; BRCA cis rs11690935 0.918 rs12692978 chr2:172725981 C/T cg13550731 chr2:172543902 DYNC1I2 -0.91 -28.21 -0.74 2.5e-114 Schizophrenia; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg05863683 chr7:1912471 MAD1L1 0.43 9.27 0.34 2.87e-19 Bipolar disorder and schizophrenia; BRCA cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.17 -0.4 1.37e-26 Colorectal cancer; BRCA cis rs5167 0.504 rs10426750 chr19:45457684 G/C cg20090143 chr19:45452003 APOC2 0.27 8.05 0.3 4.1e-15 Blood protein levels; BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg19346786 chr7:2764209 NA -0.37 -11.05 -0.4 4.19e-26 Height; BRCA cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg05025164 chr4:1340916 KIAA1530 0.42 9.38 0.35 1.17e-19 Longevity; BRCA cis rs67311347 1.000 rs2276871 chr3:40499273 C/T cg01475735 chr3:40494733 NA -0.48 -9.82 -0.36 2.74e-21 Renal cell carcinoma; BRCA cis rs17401966 0.931 rs61778401 chr1:10426474 G/A cg03954927 chr1:10346856 KIF1B 0.48 14.88 0.51 3.21e-43 Hepatocellular carcinoma; BRCA cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs12048904 0.619 rs10783153 chr1:101328230 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.52 11.64 0.42 1.49e-28 Multiple sclerosis; BRCA cis rs7607369 0.648 rs17470271 chr2:219651995 A/T cg02176678 chr2:219576539 TTLL4 0.47 12.64 0.45 7.71e-33 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs6430585 0.527 rs60966546 chr2:136401843 C/T cg07169764 chr2:136633963 MCM6 0.98 19.34 0.61 6.13e-66 Corneal structure; BRCA cis rs490234 0.651 rs13291556 chr9:128240922 T/C cg14078157 chr9:128172775 NA -0.5 -11.12 -0.4 2.21e-26 Mean arterial pressure; BRCA cis rs4805272 0.512 rs66830923 chr19:29321277 C/T cg04546413 chr19:29218101 NA 0.43 8.02 0.3 5.23e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs698833 0.538 rs1067396 chr2:44637738 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.54 10.4 0.38 1.7e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2404602 1.000 rs11072603 chr15:76881138 G/T cg23625390 chr15:77176239 SCAPER 0.39 9.59 0.35 1.94e-20 Blood metabolite levels; BRCA cis rs12995491 0.933 rs13008732 chr2:88528771 G/A cg04511125 chr2:88470314 THNSL2 -0.45 -9.2 -0.34 4.88e-19 Response to metformin (IC50); BRCA cis rs11711311 1.000 rs7645473 chr3:113516187 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.34 8.64 0.32 4.46e-17 IgG glycosylation; BRCA cis rs4478858 0.647 rs7524117 chr1:31738416 A/G cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs3741151 0.773 rs73542979 chr11:73127526 G/C cg17517138 chr11:73019481 ARHGEF17 0.88 12.73 0.45 3.1e-33 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA trans rs11098499 0.954 rs13151285 chr4:120314741 C/A cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg00071950 chr4:10020882 SLC2A9 -0.5 -11.56 -0.42 3.36e-28 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10193935 0.786 rs72796504 chr2:42406728 T/C cg27598129 chr2:42591480 NA -0.87 -14.06 -0.49 2.62e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 0.964 rs9820425 chr3:134223018 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.53 -0.61 5.8e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs453301 0.606 rs6981060 chr8:8908235 C/A cg06636001 chr8:8085503 FLJ10661 -0.47 -9.79 -0.36 3.43e-21 Joint mobility (Beighton score); BRCA cis rs73001065 0.591 rs57009615 chr19:19613622 A/G cg03709012 chr19:19516395 GATAD2A 1.01 16.14 0.54 2.16e-49 LDL cholesterol; BRCA cis rs11105298 0.891 rs11105299 chr12:89877943 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -9.98 -0.37 7.04e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.58 -0.39 3.3e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7772486 0.875 rs854145 chr6:146349650 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.97 -0.3 7.48e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9359856 0.564 rs34766278 chr6:90397132 G/C cg13799429 chr6:90582589 CASP8AP2 -0.64 -8.12 -0.31 2.47e-15 Bipolar disorder; BRCA cis rs2425143 0.730 rs6060624 chr20:34413663 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.1 -0.34 1.16e-18 Blood protein levels; BRCA trans rs9393777 0.920 rs13195040 chr6:27413924 C/T cg06606381 chr12:133084897 FBRSL1 0.72 8.07 0.3 3.54e-15 Intelligence (multi-trait analysis); BRCA cis rs7819412 0.595 rs2409712 chr8:10986837 A/C cg21775007 chr8:11205619 TDH -0.54 -11.48 -0.41 7.32e-28 Triglycerides; BRCA cis rs2153535 0.580 rs9406172 chr6:8515464 T/A cg21535247 chr6:8435926 SLC35B3 0.41 9.45 0.35 6.39e-20 Motion sickness; BRCA trans rs35110281 0.720 rs162392 chr21:44941406 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.16 0.37 1.42e-22 Mean corpuscular volume; BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.56 -0.39 4.05e-24 Lymphocyte counts; BRCA trans rs1814175 0.781 rs2866734 chr11:49886338 A/G cg15704280 chr7:45808275 SEPT13 -1.01 -32.47 -0.79 2.47e-137 Height; BRCA cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg21518248 chr2:162101506 NA -0.42 -8.63 -0.32 4.71e-17 Intelligence (multi-trait analysis); BRCA cis rs9463078 0.764 rs1935551 chr6:44786035 T/G cg25276700 chr6:44698697 NA -0.36 -8.4 -0.32 2.93e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs908922 0.676 rs533917 chr1:152518294 A/G cg20991723 chr1:152506922 NA 0.37 8.15 0.31 1.91e-15 Hair morphology; BRCA cis rs13136331 0.532 rs7375788 chr4:88565687 C/T cg22416721 chr4:88570574 DMP1 -0.59 -13.96 -0.48 7.66e-39 Sitting height ratio; BRCA cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg25019033 chr10:957182 NA -0.44 -8.3 -0.31 6.33e-16 Eosinophil percentage of granulocytes; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.86 -16.28 -0.54 4.31e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2985684 0.901 rs7146248 chr14:50112067 C/T cg04989706 chr14:50066350 PPIL5 -0.45 -8.46 -0.32 1.87e-16 Carotid intima media thickness; BRCA cis rs7267979 0.932 rs431579 chr20:25470056 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.93 0.33 4.65e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6977660 0.714 rs12700075 chr7:19791476 G/T cg07541023 chr7:19748670 TWISTNB 0.6 9.89 0.36 1.43e-21 Thyroid stimulating hormone; BRCA cis rs473651 0.503 rs515342 chr2:239367296 A/G cg21699342 chr2:239360505 ASB1 -0.57 -11.31 -0.41 3.56e-27 Multiple system atrophy; BRCA cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs17711722 0.701 rs4467826 chr7:65368708 A/G cg18876405 chr7:65276391 NA 0.71 18.84 0.6 2.68e-63 Calcium levels; BRCA cis rs12618769 0.652 rs4851145 chr2:99222916 A/G cg10123293 chr2:99228465 UNC50 -0.41 -8.34 -0.31 4.49e-16 Bipolar disorder; BRCA cis rs1011018 0.628 rs4074827 chr7:139415455 G/A cg03224163 chr7:139420300 HIPK2 -0.54 -8.82 -0.33 1.05e-17 Systolic blood pressure; BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg21143896 chr7:2802374 GNA12 -0.35 -8.48 -0.32 1.53e-16 Height; BRCA cis rs7927771 0.524 rs7936948 chr11:47704200 T/G cg20307385 chr11:47447363 PSMC3 0.42 9.52 0.35 3.42e-20 Subjective well-being; BRCA cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg21475434 chr5:93447410 FAM172A 0.66 8.53 0.32 1.03e-16 Diabetic retinopathy; BRCA cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03526776 chr6:41159608 TREML2 0.38 7.95 0.3 8.77e-15 Alzheimer's disease (late onset); BRCA cis rs2404602 0.647 rs4886840 chr15:77179002 A/G cg23625390 chr15:77176239 SCAPER -0.54 -13.82 -0.48 3.31e-38 Blood metabolite levels; BRCA cis rs10504229 0.728 rs17804774 chr8:58155950 G/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA trans rs8002861 0.664 rs9533662 chr13:44435988 T/A cg12856521 chr11:46389249 DGKZ 0.37 8.14 0.31 2.09e-15 Leprosy; BRCA cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg12863693 chr15:85201151 NMB 0.56 12.03 0.43 3.39e-30 Schizophrenia; BRCA cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg02544614 chr20:61657117 NA 0.29 8.17 0.31 1.6e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg04553112 chr3:125709451 NA -0.55 -8.27 -0.31 7.6e-16 Blood pressure (smoking interaction); BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs7572733 0.534 rs7572123 chr2:198769637 A/G cg00792783 chr2:198669748 PLCL1 0.49 10.43 0.38 1.31e-23 Dermatomyositis; BRCA trans rs208520 0.690 rs851467 chr6:66802721 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.01 -0.64 6.5e-75 Exhaled nitric oxide output; BRCA cis rs6032067 0.673 rs13042474 chr20:43893068 G/T cg06407657 chr20:43937138 MATN4;RBPJL 0.31 8.17 0.31 1.62e-15 Blood protein levels; BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg04944784 chr2:26401820 FAM59B -0.69 -11.36 -0.41 2.25e-27 Gut microbiome composition (summer); BRCA cis rs208520 1.000 rs28773210 chr6:66993566 C/T cg07460842 chr6:66804631 NA 0.88 14.14 0.49 1.11e-39 Exhaled nitric oxide output; BRCA cis rs7246967 0.673 rs16999519 chr19:22814076 A/G cg23217946 chr19:22817039 ZNF492 -0.47 -8.49 -0.32 1.4e-16 Bronchopulmonary dysplasia; BRCA cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg14844989 chr11:31128820 NA 0.45 9.6 0.36 1.79e-20 Red blood cell count; BRCA cis rs12973672 1.000 rs34832786 chr19:35769518 T/C cg12095397 chr19:35769544 USF2 0.38 8.38 0.31 3.28e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7666738 0.830 rs13133619 chr4:99067312 C/G cg17366294 chr4:99064904 C4orf37 -0.45 -10.72 -0.39 8.98e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.32 8.66 0.32 3.87e-17 Intelligence (multi-trait analysis); BRCA cis rs2882667 0.755 rs55650316 chr5:138467292 C/G cg04439458 chr5:138467593 SIL1 -0.44 -11.08 -0.4 3.21e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.59 12.5 0.44 3.12e-32 Lymphocyte counts; BRCA cis rs2289583 0.642 rs7162941 chr15:75385622 C/T cg14664628 chr15:75095509 CSK 0.39 8.94 0.33 4.03e-18 Systemic lupus erythematosus; BRCA cis rs34779708 0.966 rs17499247 chr10:35426755 A/G cg03585969 chr10:35415529 CREM 0.49 10.22 0.37 8.41e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6545883 0.931 rs7557230 chr2:61736652 A/T cg15711740 chr2:61764176 XPO1 -0.56 -14.23 -0.49 3.95e-40 Tuberculosis; BRCA cis rs11098499 0.826 rs4472123 chr4:120236630 T/A cg09307838 chr4:120376055 NA 0.61 12.85 0.45 8.45e-34 Corneal astigmatism; BRCA cis rs4889855 0.614 rs7208670 chr17:78494220 T/G cg16591659 chr17:78472290 NA -0.37 -8.19 -0.31 1.43e-15 Fractional excretion of uric acid; BRCA cis rs1865760 1.000 rs2071297 chr6:25924513 C/G cg16482183 chr6:26056742 HIST1H1C -0.54 -11.35 -0.41 2.47e-27 Height; BRCA cis rs4919694 1.000 rs11191545 chr10:104829793 C/T cg04362960 chr10:104952993 NT5C2 0.93 15.2 0.52 8.78e-45 Arsenic metabolism; BRCA cis rs208520 0.526 rs9363522 chr6:66816642 C/T cg07460842 chr6:66804631 NA -1.14 -36.01 -0.82 5.95e-156 Exhaled nitric oxide output; BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg03425785 chr20:62221387 GMEB2 0.52 8.34 0.31 4.54e-16 Glioblastoma; BRCA cis rs6460942 0.597 rs35317839 chr7:12524397 C/A cg06484146 chr7:12443880 VWDE -0.58 -7.8 -0.3 2.45e-14 Coronary artery disease; BRCA cis rs1538970 0.924 rs1494812 chr1:45876999 C/T cg05343316 chr1:45956843 TESK2 0.63 12.76 0.45 2.21e-33 Platelet count; BRCA cis rs3771570 0.901 rs28433352 chr2:242339656 A/G cg21155796 chr2:242212141 HDLBP 0.48 8.29 0.31 6.86e-16 Prostate cancer; BRCA cis rs2576037 0.526 rs649076 chr18:44414614 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 12.0 0.43 4.5e-30 Personality dimensions; BRCA cis rs79057730 0.527 rs35316052 chr7:802954 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.72 10.13 0.37 1.81e-22 Initial pursuit acceleration; BRCA cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg14061069 chr19:46274453 DMPK -0.47 -11.65 -0.42 1.45e-28 Coronary artery disease; BRCA cis rs17601876 0.651 rs12050772 chr15:51544871 T/G cg19946085 chr15:51559439 CYP19A1 -0.34 -8.89 -0.33 6.19e-18 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs11955398 0.585 rs6887434 chr5:60035420 C/G cg02684056 chr5:59996105 DEPDC1B -0.36 -8.49 -0.32 1.47e-16 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg14004847 chr7:1930337 MAD1L1 0.45 9.72 0.36 6.63e-21 Bipolar disorder and schizophrenia; BRCA cis rs7264396 0.563 rs7268195 chr20:34339854 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.84 -0.42 2.31e-29 Total cholesterol levels; BRCA trans rs9393777 0.778 rs66841633 chr6:27382386 G/T cg06606381 chr12:133084897 FBRSL1 -0.68 -7.85 -0.3 1.73e-14 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs4689388 0.926 rs4234730 chr4:6296343 A/G cg00701064 chr4:6280414 WFS1 0.69 17.68 0.57 3.18e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2011503 0.782 rs35545554 chr19:19715613 A/G cg11584989 chr19:19387371 SF4 -0.48 -9.85 -0.36 2.04e-21 Bipolar disorder; BRCA cis rs7666738 0.830 rs13121766 chr4:98935766 A/C cg05340658 chr4:99064831 C4orf37 0.65 16.04 0.54 6.49e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 8.16 0.31 1.76e-15 Diabetic retinopathy; BRCA cis rs7666738 0.830 rs6852015 chr4:99054373 C/A cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.12e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg24296786 chr1:45957014 TESK2 0.59 14.24 0.49 3.59e-40 High light scatter reticulocyte count; BRCA trans rs9354352 0.791 rs4710306 chr6:66700271 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.55 -12.09 -0.43 1.81e-30 Initial pursuit acceleration in psychotic disorders; BRCA cis rs7903847 0.642 rs11812223 chr10:99158455 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.31 -0.31 5.75e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs10754283 0.935 rs10801756 chr1:90101832 C/T cg21401794 chr1:90099060 LRRC8C 0.46 11.11 0.4 2.33e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7582180 0.764 rs10460478 chr2:100919735 G/A cg14675211 chr2:100938903 LONRF2 0.47 10.81 0.39 3.94e-25 Intelligence (multi-trait analysis); BRCA cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg12365402 chr11:9010492 NRIP3 0.42 9.24 0.34 3.62e-19 Hemoglobin concentration; BRCA cis rs17376456 0.877 rs17083462 chr5:93462401 T/G cg25358565 chr5:93447407 FAM172A 1.17 19.76 0.62 3.31e-68 Diabetic retinopathy; BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg21747090 chr2:27597821 SNX17 -0.37 -7.89 -0.3 1.33e-14 Total body bone mineral density; BRCA cis rs11148252 0.744 rs4884354 chr13:53017474 T/C cg00495681 chr13:53174319 NA 0.42 8.95 0.33 3.76e-18 Lewy body disease; BRCA cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg24675658 chr1:53192096 ZYG11B 0.63 15.12 0.51 2.25e-44 Monocyte count; BRCA cis rs9296092 0.517 rs9461877 chr6:33516667 C/T cg13560919 chr6:33536144 NA -0.83 -16.87 -0.56 4.55e-53 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.09 -0.4 2.99e-26 Lymphocyte counts; BRCA cis rs7766436 0.583 rs7757926 chr6:22561611 C/A cg13666174 chr6:22585274 NA -0.4 -8.49 -0.32 1.46e-16 Coronary artery disease; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg04025307 chr7:1156635 C7orf50 0.53 13.44 0.47 1.88e-36 Longevity;Endometriosis; BRCA trans rs11098499 0.575 rs9996586 chr4:120326942 A/G cg25214090 chr10:38739885 LOC399744 0.35 7.95 0.3 8.29e-15 Corneal astigmatism; BRCA trans rs8073060 0.586 rs35542792 chr17:33903886 A/G cg19694781 chr19:47549865 TMEM160 1.0 20.71 0.63 2.65e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs6842047 0.706 rs4862666 chr4:187136307 A/G cg09526685 chr4:187126073 CYP4V2 0.7 9.58 0.35 2.11e-20 Blood protein levels; BRCA cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg19748678 chr4:122722346 EXOSC9 0.74 16.06 0.54 5.03e-49 Type 2 diabetes; BRCA cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg23649088 chr2:200775458 C2orf69 -0.61 -7.95 -0.3 8.69e-15 Schizophrenia; BRCA cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.54 -0.44 2.13e-32 Chronic sinus infection; BRCA cis rs8114671 0.562 rs7266550 chr20:33495510 C/T cg07148914 chr20:33460835 GGT7 0.38 8.62 0.32 5.21e-17 Height; BRCA cis rs4846580 0.710 rs12407628 chr1:219935453 C/G cg07216884 chr1:219964455 NA -0.34 -7.92 -0.3 1.05e-14 Total body bone mineral density; BRCA cis rs3761847 0.622 rs10435888 chr9:123819603 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.23 0.31 1.05e-15 Rheumatoid arthritis; BRCA cis rs1829883 1.000 rs1403661 chr5:98777056 T/A cg08333243 chr5:99726346 NA -0.37 -8.81 -0.33 1.18e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs2882667 0.690 rs6421921 chr5:138167270 T/G cg04439458 chr5:138467593 SIL1 0.31 7.91 0.3 1.17e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg17644776 chr2:200775616 C2orf69 0.45 9.35 0.35 1.51e-19 Osteoporosis; BRCA cis rs56235845 0.694 rs4976643 chr5:176760227 A/C cg17509989 chr5:176798049 RGS14 0.64 12.81 0.45 1.37e-33 Hemoglobin concentration;Hematocrit; BRCA cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg01579765 chr21:45077557 HSF2BP -0.44 -12.2 -0.43 6.25e-31 Mean corpuscular volume; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg18402987 chr7:1209562 NA 0.44 8.8 0.33 1.22e-17 Longevity;Endometriosis; BRCA cis rs17601876 0.814 rs2414101 chr15:51562434 A/G cg19946085 chr15:51559439 CYP19A1 -0.39 -11.7 -0.42 8.33e-29 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs11955398 0.625 rs11739209 chr5:59959767 T/C cg02684056 chr5:59996105 DEPDC1B 0.37 8.59 0.32 6.44e-17 Intelligence (multi-trait analysis); BRCA cis rs953387 1.000 rs12473760 chr2:136905697 C/A cg05194412 chr2:137003533 NA -0.37 -8.55 -0.32 9.32e-17 Arthritis (juvenile idiopathic); BRCA cis rs7267979 0.873 rs6083853 chr20:25404541 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.58 -0.32 7.12e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs700651 0.821 rs700666 chr2:198673544 G/A cg00792783 chr2:198669748 PLCL1 0.47 10.22 0.37 8.54e-23 Intracranial aneurysm; BRCA cis rs4642101 0.765 rs1985428 chr3:12829315 A/G cg24848339 chr3:12840334 CAND2 -0.41 -10.77 -0.39 5.49e-25 QRS complex (12-leadsum); BRCA cis rs9309473 0.519 rs35421685 chr2:73910138 T/C cg20560298 chr2:73613845 ALMS1 0.38 10.06 0.37 3.37e-22 Metabolite levels; BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg08470875 chr2:26401718 FAM59B 0.76 11.89 0.43 1.33e-29 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs7775909 chr6:8477778 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.34e-24 Motion sickness; BRCA cis rs919433 0.890 rs979020 chr2:198169749 T/C cg10820045 chr2:198174542 NA -0.43 -10.07 -0.37 2.98e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4423214 0.592 rs10898223 chr11:71219264 G/A cg05163923 chr11:71159392 DHCR7 -0.46 -7.91 -0.3 1.15e-14 Vitamin D levels; BRCA cis rs3008870 1.000 rs2065001 chr1:67486509 C/G cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.26 0.64 2.92e-76 Lymphocyte percentage of white cells; BRCA trans rs11098499 0.754 rs17049949 chr4:120255290 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.6 0.39 2.72e-24 Corneal astigmatism; BRCA cis rs4243830 0.850 rs12029123 chr1:6607142 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 19.3 0.61 9.6e-66 Body mass index; BRCA cis rs6542838 0.644 rs7590596 chr2:99467938 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.11 -0.31 2.62e-15 Fear of minor pain; BRCA cis rs6964587 1.000 rs9784993 chr7:91672403 G/A cg17063962 chr7:91808500 NA 0.54 12.71 0.45 3.79e-33 Breast cancer; BRCA cis rs2415984 0.622 rs1761025 chr14:46930439 T/C cg14871534 chr14:47121158 RPL10L 0.34 8.3 0.31 6.14e-16 Number of children ever born; BRCA cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg06640241 chr16:89574553 SPG7 0.77 18.25 0.59 3.5e-60 Multiple myeloma (IgH translocation); BRCA cis rs4927850 0.709 rs6765762 chr3:195652851 G/A cg01181863 chr3:195395398 SDHAP2 -0.69 -10.69 -0.39 1.16e-24 Pancreatic cancer; BRCA cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg20933634 chr6:27740509 NA 0.43 8.77 0.33 1.58e-17 Parkinson's disease; BRCA cis rs7917772 0.503 rs1409310 chr10:104282265 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.08 0.62 6.44e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs3806843 0.900 rs2563280 chr5:140131530 G/C cg16179182 chr5:140090404 VTRNA1-1 0.41 9.13 0.34 8.91e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs6499188 0.522 rs10153230 chr16:68671741 C/G cg02972257 chr16:68554789 NA -0.44 -8.74 -0.33 2.01e-17 Ulcerative colitis; BRCA cis rs826838 1.000 rs11183469 chr12:38752311 G/A cg26384229 chr12:38710491 ALG10B 0.85 22.84 0.67 7.26e-85 Heart rate; BRCA cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg05347473 chr6:146136440 FBXO30 -0.41 -8.05 -0.3 3.92e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.72 15.5 0.52 3.24e-46 Lymphocyte counts; BRCA cis rs10181042 0.565 rs1177234 chr2:61260063 G/T cg15711740 chr2:61764176 XPO1 -0.36 -8.53 -0.32 1.05e-16 Crohn's disease; BRCA trans rs208520 0.661 rs207111 chr6:66792513 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg05207973 chr5:176823642 SLC34A1 -0.36 -7.87 -0.3 1.53e-14 Hemoglobin concentration;Hematocrit; BRCA cis rs6582630 0.555 rs10880602 chr12:38505660 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.77 0.53 1.4e-47 Drug-induced liver injury (flucloxacillin); BRCA cis rs7131987 0.676 rs10843407 chr12:29550244 A/G cg09582351 chr12:29534625 ERGIC2 0.4 9.52 0.35 3.54e-20 QT interval; BRCA cis rs4595586 0.545 rs67985200 chr12:39386891 C/T cg26384229 chr12:38710491 ALG10B 0.55 11.69 0.42 9.73e-29 Morning vs. evening chronotype; BRCA cis rs9790314 0.687 rs1037888 chr3:160775251 A/T cg04691961 chr3:161091175 C3orf57 -0.4 -8.51 -0.32 1.25e-16 Morning vs. evening chronotype; BRCA cis rs9976767 0.608 rs11909987 chr21:43822402 C/A cg23042151 chr21:43824109 UBASH3A -0.28 -8.71 -0.33 2.5e-17 Type 1 diabetes; BRCA cis rs11758351 0.660 rs2143345 chr6:26229148 C/T cg01420254 chr6:26195488 NA 0.55 8.42 0.32 2.54e-16 Gout;Renal underexcretion gout; BRCA cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs2559856 0.967 rs2695290 chr12:102087844 A/G cg12924262 chr12:102091054 CHPT1 -0.35 -7.84 -0.3 1.89e-14 Blood protein levels; BRCA cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.36 -0.38 2.27e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2797160 0.905 rs1418640 chr6:125999866 G/A cg05901451 chr6:126070800 HEY2 -0.39 -9.41 -0.35 9.06e-20 Endometrial cancer; BRCA cis rs875971 0.737 rs7803424 chr7:65880605 T/C cg18876405 chr7:65276391 NA 0.55 13.35 0.47 4.99e-36 Aortic root size; BRCA cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs12541635 0.966 rs6469028 chr8:107014552 C/T cg10147462 chr8:107024639 NA 0.36 9.67 0.36 9.96e-21 Age of smoking initiation; BRCA cis rs3125734 0.633 rs1864836 chr10:64028538 C/G cg09941381 chr10:64027924 RTKN2 -0.29 -8.12 -0.31 2.46e-15 Rheumatoid arthritis; BRCA cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg00825309 chr19:58991885 ZNF446 -0.58 -12.8 -0.45 1.44e-33 Uric acid clearance; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.48 -0.32 1.6e-16 Total body bone mineral density; BRCA cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg08917208 chr2:24149416 ATAD2B 0.91 13.38 0.47 3.55e-36 Lymphocyte counts; BRCA cis rs708547 0.874 rs1718837 chr4:57871203 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.53 13.63 0.47 2.61e-37 Response to bleomycin (chromatid breaks); BRCA cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg21433313 chr16:3507492 NAT15 0.46 10.3 0.38 4e-23 Tuberculosis; BRCA cis rs780094 0.544 rs780110 chr2:27685388 G/A cg17158414 chr2:27665306 KRTCAP3 -0.32 -8.15 -0.31 1.95e-15 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg08917208 chr2:24149416 ATAD2B 0.92 13.6 0.47 3.66e-37 Lymphocyte counts; BRCA cis rs72627509 0.904 rs781663 chr4:57781754 A/G cg26694713 chr4:57773883 REST 0.5 9.99 0.37 6.27e-22 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg27129171 chr3:47204927 SETD2 -0.69 -16.02 -0.54 8.55e-49 Colorectal cancer; BRCA trans rs35110281 0.774 rs2838327 chr21:45018566 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.36 0.31 3.95e-16 Mean corpuscular volume; BRCA cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg03433033 chr1:76189801 ACADM -0.77 -17.79 -0.58 8.21e-58 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7586879 0.789 rs13035239 chr2:25134000 T/A cg04586622 chr2:25135609 ADCY3 0.4 9.56 0.35 2.57e-20 Body mass index; BRCA trans rs9944715 0.954 rs9675387 chr18:43798023 G/A cg01718231 chr17:29326311 RNF135 -0.44 -8.63 -0.32 4.97e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg20203395 chr5:56204925 C5orf35 -0.51 -10.4 -0.38 1.64e-23 Initial pursuit acceleration; BRCA cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA cis rs9462027 0.628 rs9462015 chr6:34739726 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 7.8e-15 Systemic lupus erythematosus; BRCA cis rs7824557 0.767 rs2060463 chr8:11161610 T/G cg21775007 chr8:11205619 TDH 0.61 11.88 0.43 1.53e-29 Retinal vascular caliber; BRCA trans rs4332037 0.707 rs62435132 chr7:1891315 C/T cg25206134 chr2:45395956 NA 0.53 8.77 0.33 1.57e-17 Bipolar disorder; BRCA cis rs61931739 0.500 rs11053166 chr12:34385898 A/C cg06521331 chr12:34319734 NA 0.52 9.32 0.35 1.83e-19 Morning vs. evening chronotype; BRCA cis rs2180341 0.961 rs910720 chr6:127619070 T/C cg27446573 chr6:127587934 RNF146 0.9 21.07 0.64 2.99e-75 Breast cancer; BRCA cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg22535103 chr8:58192502 C8orf71 -0.63 -13.16 -0.46 3.62e-35 Developmental language disorder (linguistic errors); BRCA cis rs738322 0.935 rs75387 chr22:38572057 C/T cg25457927 chr22:38595422 NA -0.32 -11.88 -0.43 1.46e-29 Cutaneous nevi; BRCA trans rs8073060 0.586 rs225280 chr17:33976296 C/T cg19694781 chr19:47549865 TMEM160 -1.06 -21.42 -0.65 3.91e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs736408 0.570 rs11130327 chr3:52793239 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.4 0.38 1.6e-23 Bipolar disorder; BRCA cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg24549020 chr5:56110836 MAP3K1 0.55 11.33 0.41 3.01e-27 Initial pursuit acceleration; BRCA cis rs826838 0.967 rs826870 chr12:39120250 G/A cg13010199 chr12:38710504 ALG10B -0.43 -10.06 -0.37 3.32e-22 Heart rate; BRCA cis rs7178424 0.840 rs4774427 chr15:62217444 T/C cg00456672 chr15:62358751 C2CD4A 0.4 9.05 0.34 1.71e-18 Height; BRCA cis rs10465746 0.746 rs6663949 chr1:84452853 T/C cg10977910 chr1:84465055 TTLL7 0.59 12.39 0.44 9.11e-32 Obesity-related traits; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg15112475 chr7:1198522 ZFAND2A -0.4 -8.44 -0.32 2.16e-16 Longevity;Endometriosis; BRCA cis rs1707322 0.752 rs11211173 chr1:46219376 C/T cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9290065 0.519 rs7626904 chr3:160672427 C/T cg03342759 chr3:160939853 NMD3 -0.45 -9.33 -0.35 1.7e-19 Kawasaki disease; BRCA cis rs35306767 0.714 rs12762955 chr10:1078782 A/C cg20503657 chr10:835505 NA 0.63 10.42 0.38 1.35e-23 Eosinophil percentage of granulocytes; BRCA cis rs67460515 0.892 rs16832082 chr3:161043571 A/G cg03342759 chr3:160939853 NMD3 -0.8 -18.98 -0.6 4.9e-64 Parkinson's disease; BRCA cis rs2289583 0.544 rs12050759 chr15:75265191 G/A cg14664628 chr15:75095509 CSK 0.51 10.68 0.39 1.28e-24 Systemic lupus erythematosus; BRCA cis rs6964587 1.000 rs9785013 chr7:91674302 G/A cg17063962 chr7:91808500 NA 0.57 13.52 0.47 8.49e-37 Breast cancer; BRCA cis rs7914558 0.966 rs10748837 chr10:104880236 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.86 0.39 2.48e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg17211192 chr8:82754475 SNX16 -0.63 -11.87 -0.43 1.62e-29 Diastolic blood pressure; BRCA trans rs11764590 0.715 rs11766468 chr7:2082604 G/A cg25206134 chr2:45395956 NA 0.53 8.37 0.31 3.66e-16 Neuroticism; BRCA cis rs2806561 0.704 rs636940 chr1:23522967 A/T cg19743168 chr1:23544995 NA 0.35 8.15 0.31 1.89e-15 Height; BRCA cis rs3768617 0.565 rs2027080 chr1:183074415 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 16.99 0.56 1.09e-53 Fuchs's corneal dystrophy; BRCA cis rs17270561 0.609 rs9356986 chr6:25739119 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.8 0.33 1.28e-17 Iron status biomarkers; BRCA trans rs61931739 0.500 rs7484658 chr12:34515879 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.04e-18 Morning vs. evening chronotype; BRCA cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg14664628 chr15:75095509 CSK -0.84 -22.29 -0.66 7.26e-82 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs561341 1.000 rs564714 chr17:30318404 C/T cg23018236 chr17:30244563 NA -0.68 -10.7 -0.39 1.09e-24 Hip circumference adjusted for BMI; BRCA cis rs12200560 0.505 rs211179 chr6:97074103 A/G cg06623918 chr6:96969491 KIAA0776 0.53 12.64 0.45 7.46e-33 Coronary heart disease; BRCA cis rs2797160 1.000 rs1739374 chr6:126011825 C/T cg05901451 chr6:126070800 HEY2 0.4 9.69 0.36 8.1e-21 Endometrial cancer; BRCA cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg14456004 chr13:21872349 NA 1.16 25.28 0.71 2.73e-98 White matter hyperintensity burden; BRCA cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg21573476 chr21:45109991 RRP1B -0.36 -9.02 -0.34 2.16e-18 Mean corpuscular volume; BRCA trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.92 -0.66 7.66e-80 Intelligence (multi-trait analysis); BRCA cis rs4494114 1.000 rs9439081 chr1:39343012 A/G cg25970120 chr1:39325951 RRAGC -0.37 -7.92 -0.3 1.08e-14 Blood protein levels; BRCA cis rs6547741 0.874 rs58737572 chr2:27852118 A/C cg27432699 chr2:27873401 GPN1 0.43 8.97 0.33 3.28e-18 Oral cavity cancer; BRCA cis rs7267979 0.780 rs2500413 chr20:25241155 T/C cg08601574 chr20:25228251 PYGB 0.34 8.01 0.3 5.55e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2346177 0.554 rs34854267 chr2:46708542 T/C cg02822958 chr2:46747628 ATP6V1E2 0.58 11.31 0.41 3.68e-27 HDL cholesterol; BRCA cis rs7666738 0.535 rs6850010 chr4:98971601 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.51 0.55 2.8e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg07092213 chr7:1199455 ZFAND2A -0.44 -8.99 -0.34 2.69e-18 Longevity;Endometriosis; BRCA cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg08975724 chr8:8085496 FLJ10661 0.5 10.64 0.39 1.89e-24 Mood instability; BRCA cis rs7539409 0.604 rs6689821 chr1:84316605 A/G cg10977910 chr1:84465055 TTLL7 0.7 10.64 0.39 1.84e-24 Alzheimer's disease; BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.39 -0.32 3.1e-16 Colorectal cancer; BRCA cis rs9487051 0.768 rs427960 chr6:109524939 C/T cg01475377 chr6:109611718 NA -0.45 -10.88 -0.4 2.02e-25 Reticulocyte fraction of red cells; BRCA cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg15017067 chr4:17643749 FAM184B 0.32 9.86 0.36 1.96e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11971779 0.680 rs2355786 chr7:139065622 A/C cg07862535 chr7:139043722 LUC7L2 -0.39 -10.48 -0.38 8.19e-24 Diisocyanate-induced asthma; BRCA cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg20848291 chr7:100343083 ZAN -0.6 -12.72 -0.45 3.31e-33 Other erythrocyte phenotypes; BRCA cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg00750074 chr16:89608354 SPG7 -0.35 -9.21 -0.34 4.49e-19 Multiple myeloma (IgH translocation); BRCA cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.73e-15 Breast cancer; BRCA cis rs13064411 0.542 rs9877649 chr3:113226874 C/T cg18753928 chr3:113234510 CCDC52 -0.45 -9.6 -0.35 1.8e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.58 0.39 3.38e-24 Motion sickness; BRCA cis rs4481887 0.927 rs4279879 chr1:248486475 A/G cg00666640 chr1:248458726 OR2T12 0.32 8.94 0.33 4.09e-18 Common traits (Other); BRCA trans rs561341 1.000 rs576985 chr17:30323323 C/T cg20587970 chr11:113659929 NA -1.24 -22.64 -0.67 8.57e-84 Hip circumference adjusted for BMI; BRCA cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg10802521 chr3:52805072 NEK4 -0.34 -9.32 -0.35 1.82e-19 Electroencephalogram traits; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03352830 chr11:487213 PTDSS2 0.87 13.62 0.47 2.74e-37 Body mass index; BRCA cis rs9649213 0.614 rs4236537 chr7:97996593 T/C cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.81 -0.53 9.68e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg03923535 chr7:1197113 ZFAND2A 0.4 7.89 0.3 1.31e-14 Longevity;Endometriosis; BRCA trans rs1974653 0.781 rs175166 chr22:20116182 G/T cg20152630 chr19:46405944 MYPOP -0.38 -8.65 -0.32 4.32e-17 Schizophrenia; BRCA cis rs6594713 0.819 rs13180522 chr5:112726022 A/G cg12552261 chr5:112820674 MCC 0.46 8.1 0.31 2.72e-15 Brain cytoarchitecture; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26314531 chr2:26401878 FAM59B -0.88 -15.59 -0.52 1.14e-46 Gut microbiome composition (summer); BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg27478167 chr7:817139 HEATR2 -0.42 -8.97 -0.33 3.21e-18 Cerebrospinal P-tau181p levels; BRCA cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg23711669 chr6:146136114 FBXO30 -0.8 -19.34 -0.61 5.67e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg04450456 chr4:17643702 FAM184B 0.36 10.65 0.39 1.75e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA trans rs4332037 0.624 rs73046339 chr7:1889300 G/A cg11693508 chr17:37793320 STARD3 0.61 11.37 0.41 2.14e-27 Bipolar disorder; BRCA cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg23262073 chr20:60523788 NA -0.54 -12.72 -0.45 3.5e-33 Obesity-related traits; BRCA cis rs7301016 0.947 rs11174517 chr12:62899757 A/G cg01804193 chr12:63026212 NA -0.46 -7.91 -0.3 1.12e-14 IgG glycosylation; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg11814155 chr7:99998594 ZCWPW1 0.46 8.24 0.31 9.66e-16 Platelet count; BRCA cis rs6460942 0.915 rs17444141 chr7:12460971 T/G cg06484146 chr7:12443880 VWDE -0.75 -10.74 -0.39 7.27e-25 Coronary artery disease; BRCA cis rs7666738 0.830 rs10031190 chr4:98908683 C/A cg05340658 chr4:99064831 C4orf37 0.63 15.08 0.51 3.55e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs7551345 0.805 rs7525003 chr1:31698455 A/G cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA trans rs35110281 0.748 rs4997353 chr21:45002329 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.14 0.31 2.14e-15 Mean corpuscular volume; BRCA cis rs1707322 0.721 rs10890341 chr1:46147240 C/A cg03146154 chr1:46216737 IPP 0.52 11.57 0.42 2.93e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg18904891 chr8:8559673 CLDN23 0.64 12.63 0.45 8.69e-33 Obesity-related traits; BRCA cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs10463316 0.862 rs10071166 chr5:150768795 T/C cg03212797 chr5:150827313 SLC36A1 -0.42 -8.32 -0.31 5.27e-16 Metabolite levels (Pyroglutamine); BRCA cis rs55692411 0.537 rs13071931 chr3:50062878 G/A cg14019146 chr3:50243930 SLC38A3 -0.57 -11.74 -0.42 5.8e-29 Intelligence (multi-trait analysis); BRCA cis rs11608355 0.545 rs33997929 chr12:109912064 C/T cg05360138 chr12:110035743 NA 0.71 13.05 0.46 1.09e-34 Neuroticism; BRCA cis rs514406 0.861 rs72637996 chr1:53249618 A/T cg16325326 chr1:53192061 ZYG11B -0.65 -16.18 -0.54 1.39e-49 Monocyte count; BRCA cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.58 12.78 0.45 1.77e-33 Hemoglobin concentration; BRCA trans rs9858542 0.903 rs35999162 chr3:49597230 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.27 -0.34 2.77e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg04166393 chr7:2884313 GNA12 0.6 12.01 0.43 4.26e-30 Height; BRCA trans rs11098499 0.657 rs4463052 chr4:120313258 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.95 0.43 7.69e-30 Tonsillectomy; BRCA cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg16743903 chr16:89593216 SPG7 0.33 8.22 0.31 1.11e-15 Multiple myeloma (IgH translocation); BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.31 -8.41 -0.32 2.59e-16 Lymphocyte counts; BRCA cis rs8028182 0.636 rs12909863 chr15:75825822 G/C cg20655648 chr15:75932815 IMP3 0.42 8.23 0.31 1.05e-15 Sudden cardiac arrest; BRCA cis rs6973256 0.897 rs10235846 chr7:133328222 G/T cg07491979 chr7:133331646 EXOC4 -0.37 -8.53 -0.32 1.06e-16 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA trans rs11039798 0.660 rs717897 chr11:48375604 A/G cg03929089 chr4:120376271 NA -0.5 -8.31 -0.31 5.69e-16 Axial length; BRCA cis rs7666738 0.830 rs36047842 chr4:99004902 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6430585 0.528 rs309122 chr2:136761853 A/G cg07169764 chr2:136633963 MCM6 1.08 23.82 0.69 3.23e-90 Corneal structure; BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.85 14.2 0.49 5.56e-40 Platelet count; BRCA cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.77e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs9325144 0.600 rs10748442 chr12:38732939 A/T cg23762105 chr12:34175262 ALG10 -0.38 -9.68 -0.36 8.83e-21 Morning vs. evening chronotype; BRCA cis rs12618769 0.625 rs3769733 chr2:99100716 A/G cg10123293 chr2:99228465 UNC50 0.43 8.45 0.32 1.96e-16 Bipolar disorder; BRCA cis rs4845875 0.514 rs198392 chr1:11879162 G/A cg24844545 chr1:11908347 NPPA -0.31 -7.98 -0.3 6.92e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6878727 0.665 rs2633530 chr5:123652476 A/G cg01806427 chr5:123737813 NA -0.35 -7.84 -0.3 1.83e-14 Breast cancer; BRCA cis rs6815814 0.950 rs11725779 chr4:38811668 G/A cg02016764 chr4:38805732 TLR1 -0.6 -9.19 -0.34 5.47e-19 Breast cancer; BRCA cis rs8022179 0.580 rs8013228 chr14:103842650 A/G cg12935359 chr14:103987150 CKB -0.46 -9.28 -0.34 2.67e-19 Monocyte count; BRCA cis rs17092148 1.000 rs2378260 chr20:33374897 G/A cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs147858478 1 rs147858478 chr5:131682785 CCTGAGTT/C cg07395648 chr5:131743802 NA -0.37 -9.18 -0.34 5.74e-19 High light scatter reticulocyte percentage of red cells; BRCA cis rs1577917 0.740 rs7771612 chr6:86264374 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 12.98 0.46 2.44e-34 Response to antipsychotic treatment; BRCA cis rs1707322 1.000 rs1707338 chr1:46511981 T/G cg03146154 chr1:46216737 IPP -0.44 -9.78 -0.36 3.68e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs311392 0.903 rs6993362 chr8:55089220 A/G cg11783602 chr8:55087084 NA -0.33 -9.7 -0.36 7.55e-21 Pelvic organ prolapse (moderate/severe); BRCA cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg24562669 chr7:97807699 LMTK2 0.47 12.44 0.44 5.52e-32 Prostate cancer (SNP x SNP interaction); BRCA trans rs6964833 1.000 rs17515241 chr7:74132014 C/T cg07504079 chr7:72649617 NCF1B 0.47 9.28 0.34 2.49e-19 Menarche (age at onset); BRCA cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg16230307 chr14:35515116 FAM177A1 0.73 15.19 0.52 9.98e-45 Psoriasis; BRCA cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg05084668 chr3:125655381 ALG1L -0.46 -8.05 -0.3 4.01e-15 Blood pressure (smoking interaction); BRCA cis rs7567389 0.744 rs6430934 chr2:128000833 T/C cg09760422 chr2:128146352 NA -0.41 -8.64 -0.32 4.39e-17 Self-rated health; BRCA cis rs10193935 0.901 rs10175378 chr2:42456267 A/C cg27598129 chr2:42591480 NA -0.96 -14.7 -0.5 2.48e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs7551345 0.687 rs2377731 chr1:31697471 G/A cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA cis rs875971 0.545 rs316323 chr7:65610989 C/T cg11764359 chr7:65958608 NA -0.66 -12.14 -0.43 1.21e-30 Aortic root size; BRCA cis rs2991971 0.967 rs644915 chr1:46007002 T/C cg24296786 chr1:45957014 TESK2 0.59 14.37 0.49 9.24e-41 High light scatter reticulocyte count; BRCA cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg04267008 chr7:1944627 MAD1L1 -0.53 -11.32 -0.41 3.3e-27 Bipolar disorder and schizophrenia; BRCA cis rs2797160 0.602 rs4897150 chr6:125985540 C/T cg05901451 chr6:126070800 HEY2 -0.46 -11.43 -0.41 1.2e-27 Endometrial cancer; BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg21782813 chr7:2030301 MAD1L1 0.39 10.38 0.38 1.89e-23 Bipolar disorder and schizophrenia; BRCA cis rs7633770 0.749 rs6442011 chr3:46685722 C/T cg11219411 chr3:46661640 NA 0.64 16.69 0.55 3.46e-52 Coronary artery disease; BRCA cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg03264133 chr6:25882463 NA 0.72 16.63 0.55 7.45e-52 Blood metabolite levels; BRCA cis rs9649213 0.727 rs12113294 chr7:97910637 C/G cg24562669 chr7:97807699 LMTK2 0.33 8.08 0.3 3.14e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6089829 0.962 rs6089826 chr20:61668595 G/A cg02544614 chr20:61657117 NA 0.28 8.04 0.3 4.48e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs12926788 0.546 rs200531 chr16:24756172 G/A cg06028605 chr16:24865363 SLC5A11 -0.46 -10.07 -0.37 3.22e-22 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs68170813 0.559 rs74774133 chr7:106941449 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.96 -0.33 3.61e-18 Coronary artery disease; BRCA cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg06453172 chr10:134556979 INPP5A -0.59 -11.66 -0.42 1.34e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs11122272 0.735 rs2486746 chr1:231497324 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -12.26 -0.44 3.55e-31 Hemoglobin concentration; BRCA trans rs11098499 0.818 rs12498599 chr4:120468503 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.61 -10.36 -0.38 2.34e-23 Alzheimer's disease; BRCA cis rs847577 0.515 rs10953238 chr7:97676259 C/T cg21770322 chr7:97807741 LMTK2 0.62 17.87 0.58 3.27e-58 Breast cancer; BRCA cis rs9914988 0.943 rs12951232 chr17:27132638 G/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs12760731 0.565 rs78577576 chr1:178141982 A/G cg00404053 chr1:178313656 RASAL2 0.64 7.92 0.3 1.02e-14 Obesity-related traits; BRCA cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg13010199 chr12:38710504 ALG10B 0.36 8.63 0.32 5.05e-17 Morning vs. evening chronotype; BRCA cis rs11190604 1.000 rs10883503 chr10:102275504 C/A cg07080220 chr10:102295463 HIF1AN 0.61 13.93 0.48 1.02e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7178424 0.774 rs13379947 chr15:62184801 A/G cg00456672 chr15:62358751 C2CD4A 0.4 9.58 0.35 2.17e-20 Height; BRCA cis rs2288073 1.000 rs6708328 chr2:24412413 A/G cg06627628 chr2:24431161 ITSN2 -0.63 -12.27 -0.44 3.02e-31 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs2075371 1.000 rs2504 chr7:133979545 A/T cg02659138 chr7:134003124 SLC35B4 0.34 10.67 0.39 1.46e-24 Mean platelet volume; BRCA cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg24838063 chr12:130822603 PIWIL1 -0.54 -12.92 -0.46 4.18e-34 Menopause (age at onset); BRCA cis rs17767294 0.614 rs72850298 chr6:28222556 G/A cg08851530 chr6:28072375 NA 1.14 10.4 0.38 1.69e-23 Parkinson's disease; BRCA cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg22834771 chr12:69754056 YEATS4 -0.37 -9.16 -0.34 6.89e-19 Blood protein levels; BRCA cis rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05901451 chr6:126070800 HEY2 0.5 12.29 0.44 2.68e-31 Brugada syndrome; BRCA cis rs11601602 0.576 rs4075635 chr11:28511643 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.49 9.42 0.35 8.07e-20 Obesity-related traits; BRCA cis rs9787249 0.915 rs6664570 chr1:40206298 G/A cg02773041 chr1:40204384 PPIE 0.45 9.63 0.36 1.42e-20 Blood protein levels; BRCA cis rs6545883 0.507 rs12617371 chr2:61569134 A/G cg15711740 chr2:61764176 XPO1 0.31 7.81 0.3 2.42e-14 Tuberculosis; BRCA cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg02896835 chr1:92012615 NA 0.64 16.4 0.54 1.03e-50 Breast cancer; BRCA cis rs1050631 0.564 rs681757 chr18:33744766 A/C cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -8.01 -0.3 5.42e-15 Esophageal squamous cell cancer (length of survival); BRCA trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg03929089 chr4:120376271 NA 0.6 10.37 0.38 2.13e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs2204008 0.775 rs8186812 chr12:38305055 C/T cg13010199 chr12:38710504 ALG10B 0.45 9.32 0.35 1.81e-19 Bladder cancer; BRCA cis rs9811920 0.809 rs4928151 chr3:99767553 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.57 -13.68 -0.48 1.48e-37 Axial length; BRCA cis rs700651 0.789 rs10190226 chr2:198901564 A/G cg00792783 chr2:198669748 PLCL1 -0.38 -8.56 -0.32 8.1e-17 Intracranial aneurysm; BRCA cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg08213375 chr14:104286397 PPP1R13B 0.42 9.2 0.34 4.9e-19 Reticulocyte count; BRCA cis rs7520050 0.966 rs10890361 chr1:46346234 A/T cg03146154 chr1:46216737 IPP -0.33 -7.92 -0.3 1.08e-14 Red blood cell count;Reticulocyte count; BRCA cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg15595755 chr5:1867978 NA 0.36 8.6 0.32 6.23e-17 Cardiovascular disease risk factors; BRCA cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg04586622 chr2:25135609 ADCY3 0.45 11.28 0.41 5.02e-27 Body mass index; BRCA cis rs67981189 0.593 rs7160958 chr14:71442526 C/A cg15816911 chr14:71606274 NA 0.36 8.41 0.32 2.67e-16 Schizophrenia; BRCA cis rs11792861 0.816 rs7021366 chr9:111727670 C/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 8.44 0.32 2.16e-16 Menarche (age at onset); BRCA cis rs2882667 0.690 rs825672 chr5:138095643 A/G cg04439458 chr5:138467593 SIL1 0.32 7.89 0.3 1.33e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11890956 chr21:40555474 PSMG1 -0.61 -13.73 -0.48 9.03e-38 Menarche (age at onset); BRCA cis rs1371867 0.764 rs1020171 chr8:101288610 T/C cg06636551 chr8:101224915 SPAG1 -0.38 -8.58 -0.32 7.08e-17 Atrioventricular conduction; BRCA cis rs12760731 0.720 rs10913540 chr1:178340060 T/C cg00404053 chr1:178313656 RASAL2 0.63 8.59 0.32 6.71e-17 Obesity-related traits; BRCA cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg06671706 chr8:8559999 CLDN23 0.46 8.79 0.33 1.43e-17 Obesity-related traits; BRCA cis rs8180040 0.739 rs4683320 chr3:47152992 C/T cg27129171 chr3:47204927 SETD2 0.75 19.33 0.61 6.5e-66 Colorectal cancer; BRCA cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.78 -0.33 1.49e-17 Reticulocyte count; BRCA trans rs1493916 0.837 rs1493908 chr18:31411700 G/A cg15819921 chr19:927150 ARID3A -0.41 -8.11 -0.31 2.57e-15 Life satisfaction; BRCA cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg10556349 chr10:835070 NA 0.63 8.66 0.32 3.75e-17 Eosinophil percentage of granulocytes; BRCA cis rs10899021 1.000 rs7935426 chr11:74363890 C/T cg25880958 chr11:74394337 NA -0.5 -7.89 -0.3 1.29e-14 Response to metformin (IC50); BRCA cis rs6866614 0.627 rs27437 chr5:131436961 A/G cg14196790 chr5:131705035 SLC22A5 0.33 8.13 0.31 2.16e-15 Perceived unattractiveness to mosquitoes; BRCA cis rs1018836 0.892 rs1476428 chr8:91555603 G/T cg16814680 chr8:91681699 NA -0.5 -10.85 -0.39 2.63e-25 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs13046373 0.507 rs11088139 chr21:31978884 T/G cg24082983 chr21:31802169 KRTAP13-4 0.34 8.63 0.32 4.98e-17 HDL cholesterol; BRCA cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg05340658 chr4:99064831 C4orf37 0.69 17.54 0.57 1.68e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs939658 1.000 rs11072826 chr15:79461516 C/T cg17916960 chr15:79447300 NA 0.43 10.82 0.39 3.54e-25 Refractive error; BRCA cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg15017067 chr4:17643749 FAM184B 0.3 9.02 0.34 2.2e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs72928364 1.000 rs10511181 chr3:100689862 T/G cg10123952 chr3:100791384 NA 0.53 7.9 0.3 1.19e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg20203395 chr5:56204925 C5orf35 -0.39 -8.16 -0.31 1.75e-15 Type 2 diabetes; BRCA cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 13.62 0.47 2.81e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs72772090 0.522 rs55804164 chr5:96003075 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.55 -7.83 -0.3 2.08e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.98 0.33 3.08e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4906332 1.000 rs8012127 chr14:103942762 G/A cg19000871 chr14:103996768 TRMT61A -0.35 -8.04 -0.3 4.21e-15 Coronary artery disease; BRCA trans rs3733585 0.725 rs6449201 chr4:9973894 C/T cg26043149 chr18:55253948 FECH -0.37 -8.13 -0.31 2.23e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.36 0.38 2.4e-23 Motion sickness; BRCA cis rs55692411 0.537 rs35375092 chr3:50065274 G/A cg24110177 chr3:50126178 RBM5 -0.45 -9.77 -0.36 4e-21 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.773 rs2097810 chr7:91977226 G/A cg17063962 chr7:91808500 NA 0.53 11.7 0.42 8.77e-29 Breast cancer; BRCA cis rs4481887 0.888 rs4525076 chr1:248456876 T/G cg00666640 chr1:248458726 OR2T12 0.34 8.81 0.33 1.13e-17 Common traits (Other); BRCA cis rs7707921 0.723 rs226197 chr5:81574925 G/A cg15871215 chr5:81402204 ATG10 0.36 8.26 0.31 8.53e-16 Breast cancer; BRCA cis rs113835537 0.529 rs11227525 chr11:66308065 T/G cg24851651 chr11:66362959 CCS 0.48 8.73 0.33 2.15e-17 Airway imaging phenotypes; BRCA cis rs586533 0.881 rs658789 chr11:99501520 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.97 0.43 5.92e-30 Lung cancer in ever smokers; BRCA cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs938554 0.513 rs1014290 chr4:10001861 G/A cg00071950 chr4:10020882 SLC2A9 0.4 8.5 0.32 1.34e-16 Blood metabolite levels; BRCA cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg00631329 chr6:26305371 NA -0.55 -15.71 -0.53 2.9e-47 Educational attainment; BRCA cis rs2880765 0.545 rs11631739 chr15:86012578 T/C cg19183879 chr15:85880815 NA -0.32 -7.85 -0.3 1.7e-14 Coronary artery disease; BRCA cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg03684893 chr10:554711 DIP2C -0.41 -9.91 -0.37 1.2e-21 Psychosis in Alzheimer's disease; BRCA cis rs2762353 0.935 rs3799340 chr6:25762646 C/T cg03517284 chr6:25882590 NA 0.46 10.29 0.38 4.5e-23 Blood metabolite levels; BRCA cis rs4523957 0.928 rs749240 chr17:2186100 A/G cg16513277 chr17:2031491 SMG6 0.38 8.08 0.3 3.27e-15 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg05347473 chr6:146136440 FBXO30 0.46 9.14 0.34 7.97e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.58 9.6 0.35 1.83e-20 Lung function (FEV1/FVC); BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.61 -11.75 -0.42 5.13e-29 Gut microbiome composition (summer); BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg16606324 chr3:10149918 C3orf24 0.5 9.0 0.34 2.46e-18 Alzheimer's disease; BRCA cis rs11098499 0.955 rs35916640 chr4:120155852 T/C cg09307838 chr4:120376055 NA 0.61 11.91 0.43 1.15e-29 Corneal astigmatism; BRCA cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg20476274 chr7:133979776 SLC35B4 0.6 14.94 0.51 1.66e-43 Mean platelet volume; BRCA cis rs17381785 0.545 rs1494947 chr4:14969983 T/G cg12377275 chr4:15005593 CPEB2 0.72 17.29 0.56 2.94e-55 Urate levels in overweight individuals; BRCA cis rs13256369 1.000 rs4841017 chr8:8577093 A/G cg17143192 chr8:8559678 CLDN23 0.47 9.08 0.34 1.37e-18 Obesity-related traits; BRCA cis rs17095355 1.000 rs3862006 chr10:111750764 A/G cg00817464 chr10:111662876 XPNPEP1 0.38 9.42 0.35 8.18e-20 Biliary atresia; BRCA cis rs1185460 0.967 rs1177563 chr11:118949083 C/T cg23280166 chr11:118938394 VPS11 0.44 10.7 0.39 1.12e-24 Coronary artery disease; BRCA cis rs6582630 0.555 rs2387598 chr12:38510472 G/A cg13010199 chr12:38710504 ALG10B -0.39 -8.62 -0.32 5.09e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2304069 0.954 rs10045945 chr5:149419297 C/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.55 8.66 0.32 3.86e-17 HIV-1 control; BRCA cis rs7819412 0.521 rs11777887 chr8:11036799 C/G cg21775007 chr8:11205619 TDH 0.46 9.12 0.34 9.88e-19 Triglycerides; BRCA trans rs7824557 0.670 rs2736381 chr8:11132766 A/T cg15556689 chr8:8085844 FLJ10661 -0.33 -8.29 -0.31 6.52e-16 Retinal vascular caliber; BRCA cis rs12586317 0.547 rs12435454 chr14:35466997 A/G cg16230307 chr14:35515116 FAM177A1 0.73 15.26 0.52 4.67e-45 Psoriasis; BRCA cis rs9486715 0.838 rs4839840 chr6:96941149 T/C cg06623918 chr6:96969491 KIAA0776 0.9 25.97 0.72 4.85e-102 Headache; BRCA cis rs1707322 0.721 rs4564187 chr1:46166861 G/C cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10193935 0.901 rs3088290 chr2:42578143 A/G cg27598129 chr2:42591480 NA -0.93 -14.98 -0.51 1.11e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg03689076 chr20:33865952 NA -0.51 -9.55 -0.35 2.82e-20 Attention deficit hyperactivity disorder; BRCA cis rs7246657 0.722 rs2972458 chr19:38135403 T/C cg14683738 chr19:37701593 ZNF585B -0.46 -7.95 -0.3 8.53e-15 Coronary artery calcification; BRCA cis rs68170813 0.559 rs3801963 chr7:106898036 C/T cg02696742 chr7:106810147 HBP1 -0.47 -8.35 -0.31 4.27e-16 Coronary artery disease; BRCA cis rs16854884 0.657 rs6783089 chr3:143738034 T/C cg06585982 chr3:143692056 C3orf58 0.43 8.99 0.33 2.87e-18 Economic and political preferences (feminism/equality); BRCA cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg06671706 chr8:8559999 CLDN23 0.41 7.98 0.3 6.85e-15 Obesity-related traits; BRCA cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg18964960 chr10:1102726 WDR37 -0.48 -8.59 -0.32 6.63e-17 Response to angiotensin II receptor blocker therapy; BRCA cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.02 0.46 1.5e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11764590 0.715 rs55770986 chr7:2087823 T/C cg11693508 chr17:37793320 STARD3 0.52 9.1 0.34 1.12e-18 Neuroticism; BRCA cis rs11098499 0.909 rs1546504 chr4:120241179 C/T cg09307838 chr4:120376055 NA 0.68 14.41 0.5 5.79e-41 Corneal astigmatism; BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.54 8.44 0.32 2.2e-16 Renal function-related traits (BUN); BRCA cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg26384229 chr12:38710491 ALG10B 0.7 15.83 0.53 7.18e-48 Bladder cancer; BRCA trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21659725 chr3:3221576 CRBN 0.71 21.71 0.65 1.05e-78 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg11062466 chr8:58055876 NA 0.5 8.75 0.33 1.96e-17 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs782590 0.837 rs2627769 chr2:55927288 G/C cg18811423 chr2:55921094 PNPT1 0.79 27.77 0.74 6.49e-112 Metabolic syndrome; BRCA cis rs6867032 0.876 rs1552435 chr5:2018378 A/G cg26168224 chr5:2018326 NA 0.66 19.13 0.6 8.14e-65 Gut microbiome composition (winter); BRCA cis rs6973256 0.897 rs2430769 chr7:133349149 A/G cg07491979 chr7:133331646 EXOC4 0.39 9.05 0.34 1.75e-18 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.603 rs1998062 chr10:38457652 G/C cg00409905 chr10:38381863 ZNF37A -0.51 -10.9 -0.4 1.73e-25 Extrinsic epigenetic age acceleration; BRCA cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg18876405 chr7:65276391 NA -0.51 -11.49 -0.41 6.61e-28 Aortic root size; BRCA cis rs3820928 0.904 rs2396432 chr2:227765891 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.58e-16 Pulmonary function; BRCA cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg02659138 chr7:134003124 SLC35B4 0.33 9.39 0.35 1.05e-19 Mean platelet volume; BRCA cis rs4409675 0.576 rs6564 chr1:28212975 A/G cg23691781 chr1:28212827 C1orf38 -0.32 -10.95 -0.4 1.11e-25 Corneal astigmatism; BRCA cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg20891283 chr12:69753455 YEATS4 0.56 13.64 0.47 2.38e-37 Blood protein levels; BRCA cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg21573476 chr21:45109991 RRP1B -0.47 -11.95 -0.43 7.57e-30 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs11211232 chr1:46411146 C/T cg03146154 chr1:46216737 IPP 0.49 10.79 0.39 4.87e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.76 17.02 0.56 7.81e-54 Lymphocyte counts; BRCA cis rs698813 0.774 rs1085492 chr2:44609371 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.09 0.37 2.53e-22 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.63 10.12 0.37 1.92e-22 Renal function-related traits (BUN); BRCA cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg12927641 chr6:109611667 NA -0.42 -10.99 -0.4 7.34e-26 Reticulocyte fraction of red cells; BRCA cis rs796364 1.000 rs281760 chr2:200787804 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.78 13.12 0.46 5.41e-35 Schizophrenia; BRCA cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.84 0.3 1.89e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.875 rs9390371 chr6:146363180 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.76 0.5 1.21e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs6977660 0.714 rs10252965 chr7:19822385 A/C cg05791153 chr7:19748676 TWISTNB 0.57 10.8 0.39 4.43e-25 Thyroid stimulating hormone; BRCA cis rs9467773 1.000 rs6456734 chr6:26566965 G/T cg11502198 chr6:26597334 ABT1 0.48 9.58 0.35 2.08e-20 Intelligence (multi-trait analysis); BRCA cis rs6882046 0.513 rs676096 chr5:88035887 C/T cg22951263 chr5:87985283 NA -0.38 -10.61 -0.39 2.46e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg26587870 chr6:27730563 NA 0.42 8.97 0.33 3.26e-18 Parkinson's disease; BRCA trans rs2727020 0.656 rs7925524 chr11:49437542 G/A cg03929089 chr4:120376271 NA -0.72 -15.47 -0.52 4.26e-46 Coronary artery disease; BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg22920501 chr2:26401640 FAM59B 0.94 16.22 0.54 8.59e-50 Gut microbiome composition (summer); BRCA cis rs73242632 1.000 rs73242632 chr4:57893770 C/A cg20415529 chr4:57845134 POLR2B;C4orf14 0.66 7.82 0.3 2.17e-14 Congenital heart disease (maternal effect); BRCA cis rs1707322 0.721 rs10749856 chr1:46164846 A/T cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg01283332 chr5:1856932 NA -0.32 -7.81 -0.3 2.41e-14 Cardiovascular disease risk factors; BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg22800045 chr5:56110881 MAP3K1 0.68 12.93 0.46 3.81e-34 Initial pursuit acceleration; BRCA cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.07 0.4 3.43e-26 Bipolar disorder; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg03188948 chr7:1209495 NA 0.86 11.78 0.42 3.91e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg21782813 chr7:2030301 MAD1L1 0.33 9.12 0.34 1e-18 Bipolar disorder and schizophrenia; BRCA cis rs4474465 1.000 rs7927722 chr11:78210893 T/C cg27205649 chr11:78285834 NARS2 0.32 9.06 0.34 1.6e-18 Alzheimer's disease (survival time); BRCA cis rs3806843 0.900 rs116210441 chr5:140128649 T/A cg26395211 chr5:140044315 WDR55 0.35 7.92 0.3 1.05e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs6087990 0.806 rs4911258 chr20:31369479 G/A cg13636640 chr20:31349939 DNMT3B 0.62 19.05 0.6 1.98e-64 Ulcerative colitis; BRCA cis rs813218 0.565 rs6805884 chr3:99684808 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -8.53 -0.32 1.06e-16 Orofacial clefts; BRCA cis rs3925075 0.764 rs8044482 chr16:31345752 T/C cg02846316 chr16:31340340 ITGAM 0.54 13.37 0.47 3.83e-36 IgA nephropathy; BRCA cis rs4927850 0.957 rs4927851 chr3:195751853 A/G cg00031303 chr3:195681400 NA 0.46 8.57 0.32 7.62e-17 Pancreatic cancer; BRCA trans rs9291683 0.935 rs1860911 chr4:10275057 C/T cg26043149 chr18:55253948 FECH 0.39 8.87 0.33 7.45e-18 Bone mineral density; BRCA cis rs9467773 1.000 rs2255070 chr6:26501777 C/G cg09904177 chr6:26538194 HMGN4 0.56 18.18 0.58 7.27e-60 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.31e-23 Motion sickness; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg03188948 chr7:1209495 NA 0.87 11.85 0.42 2.11e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9467773 0.584 rs1021372 chr6:26632444 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.731 rs6846966 chr4:120293208 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.27e-14 Corneal astigmatism; BRCA cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg04553112 chr3:125709451 NA -0.53 -8.69 -0.32 3.12e-17 Blood pressure (smoking interaction); BRCA cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.84 0.45 9.69e-34 Bipolar disorder; BRCA cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg24324837 chr19:49891574 CCDC155 0.47 8.03 0.3 4.72e-15 Multiple sclerosis; BRCA cis rs7618501 0.633 rs2008877 chr3:50162291 T/G cg05623727 chr3:50126028 RBM5 -0.42 -9.83 -0.36 2.46e-21 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.508 rs1507393 chr21:31992779 A/G cg16431978 chr21:31797932 KRTAP13-3 0.35 8.89 0.33 6.35e-18 HDL cholesterol; BRCA cis rs2204008 0.776 rs8186824 chr12:38316537 A/C cg26384229 chr12:38710491 ALG10B 0.62 14.74 0.5 1.57e-42 Bladder cancer; BRCA cis rs8072100 0.875 rs9635762 chr17:45648446 A/C cg25173405 chr17:45401733 C17orf57 0.49 9.99 0.37 6.19e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4478858 0.735 rs2889730 chr1:31827159 C/T cg00250761 chr1:31883323 NA -0.33 -8.5 -0.32 1.33e-16 Alcohol dependence; BRCA cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg06494592 chr3:125709126 NA -0.54 -8.58 -0.32 7.14e-17 Blood pressure (smoking interaction); BRCA trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.86 0.33 7.66e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs7481584 0.624 rs412149 chr11:3069943 G/A cg08508325 chr11:3079039 CARS 0.29 8.64 0.32 4.52e-17 Calcium levels; BRCA cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg06636001 chr8:8085503 FLJ10661 0.58 13.37 0.47 4.16e-36 Neuroticism; BRCA cis rs2882667 0.964 rs11739351 chr5:138311742 A/G cg04439458 chr5:138467593 SIL1 -0.35 -9.5 -0.35 4.09e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg12927641 chr6:109611667 NA 0.42 11.01 0.4 5.95e-26 Reticulocyte fraction of red cells; BRCA cis rs9527 0.590 rs3781282 chr10:104852419 C/T cg04362960 chr10:104952993 NT5C2 -0.44 -10.46 -0.38 9.39e-24 Arsenic metabolism; BRCA cis rs11585357 1.000 rs11585357 chr1:17601165 C/T cg08277548 chr1:17600880 PADI3 -0.74 -12.12 -0.43 1.41e-30 Hair shape; BRCA cis rs12472274 0.617 rs7568705 chr2:239081808 C/T cg17459225 chr2:239074497 NA 0.48 10.27 0.38 5.12e-23 Phospholipid levels (plasma); BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg27170947 chr2:26402098 FAM59B -0.66 -11.37 -0.41 2.08e-27 Gut microbiome composition (summer); BRCA cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.34 0.31 4.52e-16 Schizophrenia; BRCA cis rs897080 0.515 rs786616 chr2:44592975 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.56 10.8 0.39 4.39e-25 Height; BRCA cis rs6430585 0.527 rs2289959 chr2:136423904 C/T cg07169764 chr2:136633963 MCM6 0.9 17.5 0.57 2.71e-56 Corneal structure; BRCA cis rs4566357 0.615 rs10178260 chr2:227914458 G/T cg05526886 chr2:227700861 RHBDD1 -0.39 -8.2 -0.31 1.33e-15 Coronary artery disease; BRCA cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.8 0.33 1.24e-17 Personality dimensions; BRCA cis rs1878931 0.582 rs27239 chr16:3442140 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.52 -9.03 -0.34 1.99e-18 Body mass index (adult); BRCA trans rs7200543 1.000 rs7200543 chr16:15129970 C/T cg24683922 chr1:11983373 KIAA2013 0.36 8.18 0.31 1.5e-15 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs3806843 0.838 rs2337514 chr5:140132732 T/C cg11822812 chr5:140052017 DND1 -0.32 -8.79 -0.33 1.38e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg05294307 chr14:35346193 BAZ1A -0.62 -10.42 -0.38 1.41e-23 Psoriasis; BRCA trans rs11098499 0.774 rs73842616 chr4:120290683 G/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg16006841 chr5:176797999 RGS14 0.62 11.96 0.43 6.66e-30 Hemoglobin concentration;Hematocrit; BRCA cis rs3760047 0.609 rs2541639 chr16:205035 C/T cg25425005 chr16:202905 HBZ -0.4 -8.65 -0.32 4.21e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs1371867 0.846 rs1788199 chr8:101292854 A/G cg06002616 chr8:101225028 SPAG1 -0.34 -8.28 -0.31 7.2e-16 Atrioventricular conduction; BRCA cis rs1707322 0.752 rs12024590 chr1:46127496 A/C cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg05347473 chr6:146136440 FBXO30 0.39 7.81 0.3 2.29e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs3784262 0.528 rs4646588 chr15:58304313 A/G cg12031962 chr15:58353849 ALDH1A2 0.34 8.9 0.33 5.94e-18 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs17685 0.672 rs55807301 chr7:75807401 C/A cg19862616 chr7:65841803 NCRNA00174 0.79 24.63 0.7 1.1e-94 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2032447 0.641 rs442601 chr6:25934524 G/A cg03264133 chr6:25882463 NA -0.53 -11.47 -0.41 7.9e-28 Intelligence (multi-trait analysis); BRCA cis rs4718428 0.672 rs12530806 chr7:66390724 A/G cg18252515 chr7:66147081 NA -0.55 -11.26 -0.41 6.1e-27 Corneal structure; BRCA trans rs6952808 0.608 rs58120505 chr7:2029867 T/C cg04565464 chr8:145669602 NFKBIL2 0.4 9.93 0.37 1.08e-21 Bipolar disorder and schizophrenia; BRCA cis rs9612 1.000 rs346526 chr19:44259565 A/G cg08581076 chr19:44259116 C19orf61 0.53 9.71 0.36 6.94e-21 Exhaled nitric oxide output; BRCA cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg01579765 chr21:45077557 HSF2BP -0.4 -10.93 -0.4 1.32e-25 Mean corpuscular volume; BRCA cis rs1267303 0.675 rs1267308 chr1:46987718 A/G cg25110126 chr1:46999211 NA -0.63 -11.33 -0.41 3.14e-27 Monobrow; BRCA cis rs6570726 0.764 rs448258 chr6:145869145 C/A cg23711669 chr6:146136114 FBXO30 0.79 18.88 0.6 1.64e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.898 rs72786270 chr2:24059049 G/A cg08917208 chr2:24149416 ATAD2B 0.92 13.52 0.47 8.27e-37 Lymphocyte counts; BRCA cis rs4853036 0.951 rs3755391 chr2:70141519 C/T cg02498382 chr2:70120550 SNRNP27 -0.54 -9.67 -0.36 9.57e-21 Colorectal or endometrial cancer; BRCA cis rs295137 0.799 rs4145969 chr2:201139961 C/T cg23649088 chr2:200775458 C2orf69 -0.39 -8.15 -0.31 1.87e-15 Asthma (bronchodilator response); BRCA cis rs1865721 0.771 rs62092763 chr18:73128623 T/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.23 -0.37 7.83e-23 Intelligence; BRCA cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg00031303 chr3:195681400 NA 0.45 8.53 0.32 1.05e-16 Pancreatic cancer; BRCA cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -8.48 -0.32 1.59e-16 Personality dimensions; BRCA cis rs1712517 0.873 rs7916056 chr10:104997914 T/C cg05636881 chr10:105038444 INA -0.36 -7.89 -0.3 1.36e-14 Migraine; BRCA trans rs11098499 0.955 rs13113112 chr4:120156040 C/T cg25214090 chr10:38739885 LOC399744 0.52 11.32 0.41 3.29e-27 Corneal astigmatism; BRCA cis rs3806843 1.000 rs11167600 chr5:140174865 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.82 -0.36 2.81e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs3768617 0.510 rs1413389 chr1:183096668 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA trans rs17685 0.816 rs11763076 chr7:75765963 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 27.22 0.73 6.07e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs637571 0.584 rs659824 chr11:65636509 A/G cg26695010 chr11:65641043 EFEMP2 0.42 9.31 0.35 2.05e-19 Eosinophil percentage of white cells; BRCA cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg17366294 chr4:99064904 C4orf37 0.42 9.84 0.36 2.22e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.571 rs78668714 chr7:65939451 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.14 0.37 1.71e-22 Aortic root size; BRCA cis rs71444571 1 rs71444571 chr12:123771015 G/A cg00376283 chr12:123451042 ABCB9 -0.55 -10.66 -0.39 1.63e-24 Lymphocyte percentage of white cells; BRCA cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg12927641 chr6:109611667 NA -0.42 -10.85 -0.39 2.82e-25 Reticulocyte fraction of red cells; BRCA cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg13319975 chr6:146136371 FBXO30 0.34 7.86 0.3 1.67e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.88 0.43 1.45e-29 Homoarginine levels; BRCA cis rs13161895 0.818 rs114211674 chr5:179484518 A/C cg02702477 chr5:179499311 RNF130 0.58 10.11 0.37 2.19e-22 LDL cholesterol; BRCA cis rs4588572 0.686 rs2362823 chr5:77693623 A/G cg11547950 chr5:77652471 NA 0.47 8.45 0.32 2.04e-16 Triglycerides; BRCA cis rs7172677 0.711 rs8027552 chr15:75439393 A/G cg14664628 chr15:75095509 CSK -0.36 -7.82 -0.3 2.24e-14 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs17384381 0.634 rs11801146 chr1:85915374 C/T cg16011679 chr1:85725395 C1orf52 0.5 7.84 0.3 1.85e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs910316 0.763 rs13712 chr14:75483812 T/C cg08847533 chr14:75593920 NEK9 0.87 21.77 0.65 4.72e-79 Height; BRCA cis rs59698941 0.550 rs11739194 chr5:132201230 T/C cg14825688 chr5:132208181 LEAP2 -0.38 -8.79 -0.33 1.36e-17 Apolipoprotein A-IV levels; BRCA cis rs10870270 1.000 rs10159943 chr10:133744744 T/C cg17892150 chr10:133769511 PPP2R2D -0.74 -15.76 -0.53 1.68e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg22800045 chr5:56110881 MAP3K1 0.62 11.85 0.42 2.01e-29 Initial pursuit acceleration; BRCA cis rs9611519 0.589 rs8138917 chr22:41412425 T/C cg03806693 chr22:41940476 POLR3H -0.4 -7.81 -0.3 2.29e-14 Neuroticism; BRCA cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -11.45 -0.41 9.65e-28 Neuroticism; BRCA cis rs8014204 0.736 rs2111705 chr14:75261641 G/A cg06637938 chr14:75390232 RPS6KL1 0.43 8.8 0.33 1.25e-17 Caffeine consumption; BRCA cis rs6450176 1.000 rs3776703 chr5:53305259 T/C ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.39 -0.52 1.09e-45 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7267979 1.000 rs4815404 chr20:25301845 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.37 -0.35 1.21e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9399135 0.967 rs9389254 chr6:135330709 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.45 0.44 5.39e-32 Red blood cell count; BRCA cis rs2075371 0.932 rs1035328 chr7:133978419 T/C cg11752832 chr7:134001865 SLC35B4 0.5 12.85 0.45 8.99e-34 Mean platelet volume; BRCA cis rs889312 0.500 rs1867731 chr5:56132115 C/G cg24531977 chr5:56204891 C5orf35 -0.41 -8.74 -0.33 2.04e-17 Breast cancer;Breast cancer (early onset); BRCA cis rs4631830 0.683 rs11004409 chr10:51498019 G/C cg20129853 chr10:51489980 NA 0.32 8.66 0.32 3.98e-17 Prostate-specific antigen levels; BRCA trans rs6951245 0.554 rs10270249 chr7:1151886 G/T cg13565492 chr6:43139072 SRF -0.87 -16.03 -0.54 7.52e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs561341 1.000 rs510264 chr17:30323414 A/G cg00745463 chr17:30367425 LRRC37B -0.61 -9.81 -0.36 2.98e-21 Hip circumference adjusted for BMI; BRCA cis rs796364 0.806 rs35200468 chr2:201110368 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.58 -8.24 -0.31 9.87e-16 Schizophrenia; BRCA cis rs72615157 0.539 rs72615159 chr7:99674286 G/A cg22004693 chr7:99632812 ZKSCAN1 0.54 11.62 0.42 1.88e-28 Lung function (FEV1/FVC); BRCA cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.47 0.32 1.74e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs8180040 0.966 rs11130129 chr3:47489885 G/C cg16586182 chr3:47516702 SCAP 0.66 15.26 0.52 4.86e-45 Colorectal cancer; BRCA cis rs992157 0.661 rs10171839 chr2:219051314 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.47 10.54 0.38 4.79e-24 Colorectal cancer; BRCA cis rs34779708 0.966 rs998658 chr10:35408654 A/G cg03585969 chr10:35415529 CREM 0.44 9.4 0.35 9.55e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg04315214 chr1:2043799 PRKCZ 0.44 11.85 0.42 1.99e-29 Height; BRCA cis rs2073300 0.609 rs6137920 chr20:23363436 C/T cg12062639 chr20:23401060 NAPB 0.96 13.45 0.47 1.64e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4660306 0.961 rs12145526 chr1:45969036 G/C cg24296786 chr1:45957014 TESK2 0.43 8.47 0.32 1.66e-16 Homocysteine levels; BRCA cis rs72627509 0.857 rs55762216 chr4:57765731 G/C cg26694713 chr4:57773883 REST 0.47 8.58 0.32 7.34e-17 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs11098499 0.909 rs1546504 chr4:120241179 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.54 0.32 1e-16 Corneal astigmatism; BRCA cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs4727443 0.932 rs7803714 chr7:99585150 G/T cg22004693 chr7:99632812 ZKSCAN1 0.39 8.75 0.33 1.91e-17 Interstitial lung disease; BRCA cis rs17376456 0.809 rs10476602 chr5:93445255 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.28 0.31 7.46e-16 Diabetic retinopathy; BRCA cis rs10851411 0.559 rs56172155 chr15:42882182 C/T cg21293051 chr15:42870591 STARD9 0.55 8.86 0.33 7.6e-18 Glucose homeostasis traits; BRCA cis rs6963495 0.818 rs117028299 chr7:105162310 T/C cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg03433033 chr1:76189801 ACADM -0.5 -9.9 -0.36 1.35e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17253792 0.822 rs2274075 chr14:56096731 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs6831352 0.959 rs1139490 chr4:100045141 C/T cg12011299 chr4:100065546 ADH4 0.5 13.37 0.47 3.94e-36 Alcohol dependence; BRCA cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.92 23.0 0.67 9.66e-86 Subjective well-being; BRCA cis rs9463078 0.764 rs1854547 chr6:44912366 G/A cg25276700 chr6:44698697 NA -0.36 -8.38 -0.31 3.37e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs5997397 0.934 rs6005864 chr22:29157487 A/G cg02153584 chr22:29168773 CCDC117 -0.52 -11.77 -0.42 4.24e-29 Red cell distribution width; BRCA cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.31 0.35 2.08e-19 Motion sickness; BRCA cis rs2243480 0.901 rs12530490 chr7:65691647 G/A cg18252515 chr7:66147081 NA 1.07 15.89 0.53 3.53e-48 Diabetic kidney disease; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg04025307 chr7:1156635 C7orf50 0.57 10.07 0.37 2.98e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg19318889 chr4:1322082 MAEA 0.57 11.84 0.42 2.31e-29 Longevity; BRCA cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg10295955 chr4:187884368 NA -0.99 -31.64 -0.78 6.55e-133 Lobe attachment (rater-scored or self-reported); BRCA cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg01028140 chr2:1542097 TPO -0.58 -12.18 -0.43 8e-31 IgG glycosylation; BRCA cis rs1577917 1.000 rs35797755 chr6:86706554 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.41 -0.44 7.49e-32 Response to antipsychotic treatment; BRCA cis rs698833 0.819 rs2340810 chr2:44536546 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.51 -10.53 -0.38 5.28e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs600806 0.821 rs3879447 chr1:109891403 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.19 0.31 1.42e-15 Intelligence (multi-trait analysis); BRCA cis rs870825 0.929 rs72689278 chr4:185593718 C/T cg04058563 chr4:185651563 MLF1IP 0.84 14.09 0.49 1.87e-39 Blood protein levels; BRCA trans rs7824557 0.767 rs1897951 chr8:11169854 C/T cg06636001 chr8:8085503 FLJ10661 0.54 10.2 0.37 9.99e-23 Retinal vascular caliber; BRCA cis rs12950390 0.853 rs4794107 chr17:45843159 T/G cg03474202 chr17:45855739 NA -0.47 -12.59 -0.45 1.28e-32 IgG glycosylation; BRCA cis rs11105298 0.891 rs4842653 chr12:89834113 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.88 -0.36 1.58e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg25767906 chr1:53392781 SCP2 -0.38 -8.61 -0.32 5.89e-17 Monocyte count; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg09877947 chr5:131593287 PDLIM4 0.4 10.33 0.38 3.19e-23 Breast cancer; BRCA cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.61 15.67 0.53 4.44e-47 Bone mineral density (spine);Bone mineral density; BRCA cis rs7647973 0.588 rs62262675 chr3:49673662 A/G cg03060546 chr3:49711283 APEH -0.61 -8.63 -0.32 4.84e-17 Menarche (age at onset); BRCA cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg01579765 chr21:45077557 HSF2BP -0.41 -10.87 -0.39 2.36e-25 Mean corpuscular volume; BRCA cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg08807101 chr21:30365312 RNF160 0.75 19.8 0.62 2.09e-68 Dental caries; BRCA cis rs9309473 0.950 rs73947808 chr2:73721250 A/C cg20560298 chr2:73613845 ALMS1 -0.48 -11.53 -0.41 4.49e-28 Metabolite levels; BRCA cis rs708547 0.914 rs58228066 chr4:57735787 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.49 -11.06 -0.4 3.87e-26 Response to bleomycin (chromatid breaks); BRCA cis rs6893300 0.524 rs6601073 chr5:179177271 A/G cg14593053 chr5:179126677 CANX -0.47 -12.95 -0.46 3.01e-34 Resting heart rate; BRCA cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg23262073 chr20:60523788 NA 0.56 13.0 0.46 1.88e-34 Obesity-related traits; BRCA cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg06618935 chr21:46677482 NA -0.37 -8.15 -0.31 1.98e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs2197308 0.765 rs11182992 chr12:37935572 G/C cg06521331 chr12:34319734 NA -0.53 -9.52 -0.35 3.46e-20 Morning vs. evening chronotype; BRCA cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg19077165 chr18:44547161 KATNAL2 -0.57 -12.39 -0.44 9.42e-32 Personality dimensions; BRCA cis rs875971 0.929 rs10950041 chr7:65973875 T/C cg18876405 chr7:65276391 NA 0.54 12.99 0.46 2.18e-34 Aortic root size; BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -11.27 -0.41 5.52e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg24082983 chr21:31802169 KRTAP13-4 0.33 8.24 0.31 9.41e-16 HDL cholesterol; BRCA cis rs17685 0.672 rs55807301 chr7:75807401 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.36 -8.24 -0.31 9.96e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg05535760 chr7:792225 HEATR2 -0.87 -14.92 -0.51 2.1e-43 Cerebrospinal P-tau181p levels; BRCA trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs12711979 0.875 rs11686157 chr2:3855020 C/G cg17052675 chr2:3827356 NA -0.41 -11.23 -0.41 8.03e-27 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs11190604 0.943 rs113791644 chr10:102324330 T/G cg07080220 chr10:102295463 HIF1AN 0.6 13.97 0.48 6.82e-39 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7267979 1.000 rs6050631 chr20:25431749 C/T cg08601574 chr20:25228251 PYGB 0.33 7.95 0.3 8.31e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8180040 0.726 rs2061197 chr3:47001350 C/T cg16586182 chr3:47516702 SCAP 0.52 11.36 0.41 2.2e-27 Colorectal cancer; BRCA cis rs7246657 0.882 rs6508719 chr19:37877419 A/G cg23950597 chr19:37808831 NA -0.61 -11.22 -0.41 8.27e-27 Coronary artery calcification; BRCA cis rs9487051 0.803 rs410449 chr6:109539853 C/T cg21918786 chr6:109611834 NA -0.35 -8.99 -0.33 2.86e-18 Reticulocyte fraction of red cells; BRCA cis rs8031584 0.781 rs4779498 chr15:31177476 C/T cg14829155 chr15:31115871 NA -0.52 -12.2 -0.43 6.11e-31 Huntington's disease progression; BRCA cis rs1008375 1.000 rs7673500 chr4:17621383 C/T cg15017067 chr4:17643749 FAM184B 0.29 8.84 0.33 9.21e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6882046 0.513 rs34318 chr5:88027149 G/A cg22951263 chr5:87985283 NA -0.38 -10.68 -0.39 1.27e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg11057378 chr10:81107060 PPIF 0.4 9.46 0.35 5.85e-20 Height; BRCA cis rs921968 0.541 rs599973 chr2:219387273 C/G cg10223061 chr2:219282414 VIL1 -0.27 -8.11 -0.31 2.61e-15 Mean corpuscular hemoglobin concentration; BRCA trans rs4596713 0.538 rs6560589 chr9:71749540 A/T cg16512924 chr15:28394682 HERC2 0.41 9.85 0.36 2.06e-21 Headache; BRCA cis rs6700896 0.931 rs12043644 chr1:66147348 A/G cg04111102 chr1:66153794 NA 0.34 8.46 0.32 1.89e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs875971 0.862 rs6952182 chr7:65683317 T/G cg18876405 chr7:65276391 NA -0.51 -11.39 -0.41 1.75e-27 Aortic root size; BRCA cis rs6484504 0.576 rs2447671 chr11:31334323 A/G cg14844989 chr11:31128820 NA -0.41 -8.97 -0.33 3.23e-18 Red blood cell count; BRCA cis rs752010 0.530 rs10789401 chr1:42081111 A/G cg06885757 chr1:42089581 HIVEP3 0.4 12.99 0.46 2.15e-34 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs61931739 0.534 rs11053029 chr12:34131766 G/T cg06521331 chr12:34319734 NA -0.62 -11.27 -0.41 5.54e-27 Morning vs. evening chronotype; BRCA cis rs243505 0.733 rs9987055 chr7:148501758 G/A cg09806900 chr7:148480153 CUL1 0.52 10.77 0.39 5.46e-25 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg18402987 chr7:1209562 NA 0.85 12.2 0.43 6.3e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs28374715 0.580 rs8030228 chr15:41636867 A/G cg18705301 chr15:41695430 NDUFAF1 -0.89 -21.47 -0.65 2.02e-77 Ulcerative colitis; BRCA cis rs8114671 0.562 rs6087644 chr20:33480917 G/C cg07148914 chr20:33460835 GGT7 0.47 9.96 0.37 7.88e-22 Height; BRCA cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg20476274 chr7:133979776 SLC35B4 0.7 21.47 0.65 2.08e-77 Mean platelet volume; BRCA cis rs6120849 0.663 rs6119548 chr20:33552612 A/G cg24642439 chr20:33292090 TP53INP2 0.59 10.26 0.38 5.53e-23 Protein C levels; BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -11.2 -0.41 1.03e-26 Platelet count; BRCA cis rs2073300 0.609 rs17830281 chr20:23350525 C/T cg12062639 chr20:23401060 NAPB 0.94 13.43 0.47 2.14e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs3780486 0.713 rs3780489 chr9:33129844 G/T cg04842962 chr6:43655489 MRPS18A 1.11 38.52 0.84 9.34e-169 IgG glycosylation; BRCA cis rs507080 0.922 rs525485 chr11:118555754 C/T cg09144398 chr11:118550485 TREH -0.37 -8.8 -0.33 1.24e-17 Serum metabolite levels; BRCA cis rs11718455 0.960 rs11929518 chr3:44016874 A/G cg08738300 chr3:44038990 NA 0.46 8.89 0.33 6.4e-18 Coronary artery disease; BRCA cis rs9814567 1.000 rs2177601 chr3:134245434 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7666738 0.830 rs2903150 chr4:99027184 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2066819 1.000 rs77120931 chr12:56646213 A/C cg26714650 chr12:56694279 CS -1.16 -15.39 -0.52 1.09e-45 Psoriasis vulgaris; BRCA cis rs7586879 0.639 rs3903070 chr2:25123463 C/G cg01884057 chr2:25150051 NA 0.35 9.25 0.34 3.24e-19 Body mass index; BRCA cis rs72772090 0.539 rs35898772 chr5:96179685 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -11.43 -0.41 1.14e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs147649347 1 rs147649347 chr2:24210076 GATAA/G cg20701182 chr2:24300061 SF3B14 0.67 10.02 0.37 4.78e-22 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg00106254 chr7:1943704 MAD1L1 -0.31 -8.18 -0.31 1.55e-15 Schizophrenia; BRCA cis rs2479724 0.935 rs2025951 chr6:41827193 C/T cg17623882 chr6:41773611 USP49 0.38 10.36 0.38 2.32e-23 Menarche (age at onset); BRCA cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg11752832 chr7:134001865 SLC35B4 0.5 11.35 0.41 2.45e-27 Mean platelet volume; BRCA cis rs9341808 0.644 rs62408577 chr6:80942024 T/A cg08355045 chr6:80787529 NA -0.32 -7.85 -0.3 1.72e-14 Sitting height ratio; BRCA cis rs67478160 0.595 rs12433109 chr14:104196607 G/A cg08213375 chr14:104286397 PPP1R13B 0.59 15.24 0.52 5.63e-45 Schizophrenia; BRCA cis rs4268898 0.610 rs34216622 chr2:24463445 G/C cg06627628 chr2:24431161 ITSN2 -0.79 -15.05 -0.51 5.04e-44 Asthma; BRCA trans rs1459104 0.714 rs36018195 chr11:55172856 G/A cg15704280 chr7:45808275 SEPT13 0.66 8.25 0.31 8.81e-16 Body mass index; BRCA cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg12386194 chr3:101231763 SENP7 0.4 8.56 0.32 8.25e-17 Colorectal cancer; BRCA cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg08219700 chr8:58056026 NA 0.45 8.17 0.31 1.62e-15 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.98 -0.33 3.1e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs10489202 0.634 rs6427119 chr1:168074145 A/G cg24449463 chr1:168025552 DCAF6 0.47 14.97 0.51 1.21e-43 Schizophrenia; BRCA trans rs2832077 1.000 rs2832065 chr21:30135362 C/T cg14791747 chr16:20752902 THUMPD1 0.4 9.39 0.35 1.07e-19 Cognitive test performance; BRCA cis rs17688601 0.951 rs17621345 chr7:40875192 A/C cg05119115 chr7:40866195 C7orf10 -0.55 -10.96 -0.4 9.58e-26 Pancreatic cancer; BRCA cis rs853679 0.517 rs34716816 chr6:28046169 C/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.15e-15 Depression; BRCA cis rs832540 0.931 rs1445996 chr5:56235548 C/T cg24531977 chr5:56204891 C5orf35 0.4 7.98 0.3 6.8e-15 Coronary artery disease; BRCA cis rs9316337 0.843 rs9509683 chr13:21977812 A/G cg21011702 chr13:21951294 ZDHHC20 -0.3 -7.81 -0.3 2.41e-14 Schizophrenia; BRCA cis rs6545883 1.000 rs778758 chr2:61782161 T/C cg15711740 chr2:61764176 XPO1 -0.56 -14.15 -0.49 9.36e-40 Tuberculosis; BRCA cis rs11690935 0.885 rs6725388 chr2:172730015 G/C cg13550731 chr2:172543902 DYNC1I2 -0.83 -25.83 -0.71 2.58e-101 Schizophrenia; BRCA cis rs889312 0.500 rs832580 chr5:56172646 T/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.38 -0.31 3.28e-16 Breast cancer;Breast cancer (early onset); BRCA cis rs2380220 0.606 rs7754906 chr6:95992429 C/T cg15832292 chr6:96025679 MANEA 0.48 8.03 0.3 4.75e-15 Behavioural disinhibition (generation interaction); BRCA cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.8 -0.39 4.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.55 -10.12 -0.37 1.93e-22 Renal function-related traits (BUN); BRCA cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.720 rs1611764 chr1:152957887 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.75 -0.33 1.83e-17 Inflammatory skin disease; BRCA cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg18446336 chr7:2847575 GNA12 -0.41 -9.25 -0.34 3.42e-19 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs7927592 0.763 rs596494 chr11:68251054 T/G cg01657329 chr11:68192670 LRP5 -0.34 -7.94 -0.3 9.15e-15 Total body bone mineral density; BRCA cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08109568 chr15:31115862 NA -0.44 -10.46 -0.38 9.93e-24 Huntington's disease progression; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.0 -0.34 2.59e-18 Total body bone mineral density; BRCA cis rs3733585 0.577 rs5014939 chr4:9953253 T/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.61e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4363385 0.747 rs4845330 chr1:152981505 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs9790314 1.000 rs336593 chr3:161076431 T/C cg03342759 chr3:160939853 NMD3 -0.54 -11.61 -0.42 2.17e-28 Morning vs. evening chronotype; BRCA cis rs1559088 0.501 rs8100568 chr19:33567565 T/C cg17764715 chr19:33622953 WDR88 0.52 8.39 0.32 3.01e-16 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs16958440 0.867 rs77348110 chr18:44674167 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.89 0.48 1.53e-38 Sitting height ratio; BRCA cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg01689657 chr7:91764605 CYP51A1 0.22 7.9 0.3 1.23e-14 Breast cancer; BRCA cis rs9297145 0.585 rs62473049 chr7:98777685 T/C cg05967295 chr7:98741636 SMURF1 -0.64 -14.17 -0.49 7.42e-40 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg12193833 chr17:30244370 NA -0.58 -8.78 -0.33 1.54e-17 Hip circumference adjusted for BMI; BRCA cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg02527881 chr3:46936655 PTH1R -0.37 -9.38 -0.35 1.09e-19 Colorectal cancer; BRCA trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.11 0.34 1.02e-18 Resting heart rate; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg18404041 chr3:52824283 ITIH1 -0.29 -8.77 -0.33 1.67e-17 Bipolar disorder; BRCA cis rs4662945 0.525 rs10174479 chr2:130296287 A/C cg05962382 chr2:130345044 NA -0.33 -8.0 -0.3 5.82e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg12311346 chr5:56204834 C5orf35 -0.78 -15.45 -0.52 5.29e-46 Initial pursuit acceleration; BRCA cis rs7512552 0.839 rs12040949 chr1:150447462 C/T cg15654264 chr1:150340011 RPRD2 0.43 9.18 0.34 5.69e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg11584989 chr19:19387371 SF4 0.31 7.88 0.3 1.44e-14 Tonsillectomy; BRCA cis rs12142240 0.698 rs6667861 chr1:46815749 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.87 -0.33 7.49e-18 Developmental language disorder (linguistic errors); BRCA cis rs9287719 0.967 rs10195802 chr2:10754532 C/T cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs2832191 0.679 rs2705659 chr21:30363908 G/C cg08807101 chr21:30365312 RNF160 0.77 20.35 0.63 2.33e-71 Dental caries; BRCA cis rs9811920 0.514 rs1287283 chr3:99515750 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.62 -13.8 -0.48 4.14e-38 Axial length; BRCA cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg00686598 chr14:53173677 PSMC6 -1.05 -15.17 -0.51 1.28e-44 Alzheimer's disease (late onset); BRCA cis rs7123876 0.830 rs59311588 chr11:72435996 A/G cg03713592 chr11:72463424 ARAP1 0.62 11.08 0.4 3.08e-26 Body mass index; BRCA cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg27129171 chr3:47204927 SETD2 0.68 15.82 0.53 8.12e-48 Colorectal cancer; BRCA cis rs7103648 0.966 rs1534576 chr11:47419663 A/C cg03711944 chr11:47377212 SPI1 0.42 11.41 0.41 1.45e-27 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs7267979 0.966 rs910996 chr20:25264196 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.32 0.35 1.93e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.57 0.39 3.5e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg00531865 chr16:30841666 NA -0.38 -9.1 -0.34 1.14e-18 Dementia with Lewy bodies; BRCA cis rs2625529 0.824 rs7170754 chr15:72218594 G/A cg16672083 chr15:72433130 SENP8 -0.83 -17.2 -0.56 8.64e-55 Red blood cell count; BRCA cis rs6842047 1.000 rs4862665 chr4:187136142 C/T cg09526685 chr4:187126073 CYP4V2 -0.64 -9.39 -0.35 1.04e-19 Blood protein levels; BRCA cis rs11718455 0.960 rs35711021 chr3:44004791 G/A cg08738300 chr3:44038990 NA 0.45 8.7 0.33 2.79e-17 Coronary artery disease; BRCA cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg26384229 chr12:38710491 ALG10B 0.8 19.69 0.61 7.86e-68 Heart rate; BRCA cis rs7584330 0.518 rs6715245 chr2:238445803 C/T cg08992911 chr2:238395768 MLPH 0.55 8.92 0.33 4.83e-18 Prostate cancer; BRCA cis rs7809950 0.635 rs62483629 chr7:106866178 T/C cg23024343 chr7:107201750 COG5 -0.45 -8.93 -0.33 4.59e-18 Coronary artery disease; BRCA cis rs7666738 0.830 rs11097598 chr4:98946057 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.21e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6964587 1.000 rs2282970 chr7:91584281 A/G cg17063962 chr7:91808500 NA 0.57 13.47 0.47 1.42e-36 Breast cancer; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg27170947 chr2:26402098 FAM59B -0.84 -13.57 -0.47 4.83e-37 Gut microbiome composition (summer); BRCA cis rs1707322 0.721 rs7519900 chr1:46234947 C/T cg03146154 chr1:46216737 IPP 0.54 12.05 0.43 2.88e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7819412 0.505 rs17782536 chr8:11021682 A/G cg21775007 chr8:11205619 TDH -0.49 -9.48 -0.35 4.89e-20 Triglycerides; BRCA cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.78 17.7 0.57 2.46e-57 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7572263 0.724 rs10497896 chr2:209049899 G/C cg23998903 chr2:209048830 C2orf80 -0.4 -8.39 -0.31 3.15e-16 Glioma;Non-glioblastoma glioma; BRCA cis rs4319547 0.656 rs1553179 chr12:122831073 A/G cg05707623 chr12:122985044 ZCCHC8 -0.49 -9.43 -0.35 7.35e-20 Body mass index; BRCA cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg25319279 chr11:5960081 NA -0.43 -8.25 -0.31 9.22e-16 DNA methylation (variation); BRCA cis rs9443189 0.615 rs618239 chr6:76350038 A/G cg01950844 chr6:76311363 SENP6 0.83 13.32 0.47 6.61e-36 Prostate cancer; BRCA cis rs7572733 0.515 rs13382697 chr2:198920560 A/C cg00792783 chr2:198669748 PLCL1 0.4 8.82 0.33 1.05e-17 Dermatomyositis; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg24060327 chr5:131705240 SLC22A5 0.41 8.0 0.3 5.71e-15 Acylcarnitine levels; BRCA cis rs1691799 0.867 rs1168341 chr12:66759080 G/C cg16791601 chr12:66731901 HELB -0.66 -18.11 -0.58 1.7e-59 White blood cell count (basophil); BRCA cis rs59698941 0.527 rs1557852 chr5:132181800 G/A cg14825688 chr5:132208181 LEAP2 -0.37 -8.65 -0.32 4.12e-17 Apolipoprotein A-IV levels; BRCA cis rs11955398 0.546 rs10050803 chr5:60038225 G/A cg02684056 chr5:59996105 DEPDC1B -0.34 -7.91 -0.3 1.16e-14 Intelligence (multi-trait analysis); BRCA cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg11366901 chr6:160182831 ACAT2 0.78 14.93 0.51 1.81e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs2742234 0.955 rs2435384 chr10:43673731 G/T cg15436174 chr10:43711423 RASGEF1A -0.43 -8.91 -0.33 5.1e-18 Hirschsprung disease; BRCA cis rs13191362 0.935 rs7767254 chr6:162954674 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.21 0.31 1.25e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.909 rs28714195 chr4:120316950 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.94 0.3 9.1e-15 Corneal astigmatism; BRCA cis rs8054556 0.787 rs3814877 chr16:30042677 G/T cg06326092 chr16:30034487 C16orf92 0.32 8.0 0.3 6.03e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7833986 0.501 rs2953911 chr8:56948009 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.75 14.16 0.49 8.42e-40 Height; BRCA cis rs1865760 1.000 rs7770139 chr6:25925823 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 11.32 0.41 3.3e-27 Height; BRCA cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.647 rs35710279 chr15:77082234 T/A cg23625390 chr15:77176239 SCAPER -0.55 -12.87 -0.45 6.85e-34 Blood metabolite levels; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 9.11 0.34 1.05e-18 Platelet count; BRCA cis rs826838 0.967 rs1719858 chr12:39124505 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.35 -0.38 2.55e-23 Heart rate; BRCA cis rs4588572 0.601 rs6867673 chr5:77779125 A/G cg11547950 chr5:77652471 NA -0.49 -8.62 -0.32 5.25e-17 Triglycerides; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg05221455 chr11:829616 EFCAB4A -0.37 -8.16 -0.31 1.73e-15 Mean platelet volume; BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.78 0.42 4.11e-29 Tonsillectomy; BRCA cis rs7582180 0.676 rs10048665 chr2:100933085 A/G cg14675211 chr2:100938903 LONRF2 0.47 11.01 0.4 6.24e-26 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg05623727 chr3:50126028 RBM5 -0.49 -12.08 -0.43 2.03e-30 Intelligence (multi-trait analysis); BRCA cis rs9457247 0.582 rs9459855 chr6:167466150 G/T cg07741184 chr6:167504864 NA 0.36 10.42 0.38 1.42e-23 Crohn's disease; BRCA cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -9.21 -0.34 4.74e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2882667 1.000 rs2060222 chr5:138308466 C/T cg04439458 chr5:138467593 SIL1 -0.37 -9.85 -0.36 2.08e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10883723 0.810 rs2281879 chr10:104268877 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.46 0.63 5.84e-72 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2816062 0.775 rs2745315 chr1:18897118 G/A cg18795169 chr1:18902165 NA -0.93 -27.15 -0.73 1.48e-108 Urate levels in lean individuals; BRCA cis rs11719291 0.504 rs71324924 chr3:48865444 G/A cg00383909 chr3:49044727 WDR6 0.96 15.69 0.53 3.76e-47 Cognitive function; BRCA cis rs4803468 0.904 rs60781668 chr19:41944842 A/T cg09537434 chr19:41945824 ATP5SL 1.03 25.55 0.71 9.48e-100 Height; BRCA cis rs2404602 0.735 rs11637490 chr15:76759565 A/G cg23625390 chr15:77176239 SCAPER -0.51 -12.37 -0.44 1.11e-31 Blood metabolite levels; BRCA cis rs1577917 0.740 rs9353320 chr6:86244848 C/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 9.04 0.34 1.88e-18 Response to antipsychotic treatment; BRCA cis rs2486288 0.656 rs12908818 chr15:45571668 A/G cg15395560 chr15:45543142 SLC28A2 0.29 7.93 0.3 9.86e-15 Glomerular filtration rate; BRCA cis rs28830936 1.000 rs11637341 chr15:41955825 G/T cg17847044 chr15:42102381 MAPKBP1 -0.34 -9.64 -0.36 1.27e-20 Diastolic blood pressure; BRCA cis rs7659604 0.628 rs3828485 chr4:122722368 G/A cg19748678 chr4:122722346 EXOSC9 0.74 16.02 0.54 8.42e-49 Type 2 diabetes; BRCA cis rs17270561 0.609 rs9358876 chr6:25738956 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.8 0.33 1.28e-17 Iron status biomarkers; BRCA cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg18230493 chr5:56204884 C5orf35 -0.58 -11.53 -0.42 4.37e-28 Type 2 diabetes; BRCA cis rs870825 0.549 rs7656993 chr4:185635159 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.57 0.57 1.07e-56 Blood protein levels; BRCA cis rs6866344 0.570 rs1079487 chr5:178136005 G/A cg03877680 chr5:178157825 ZNF354A 0.84 16.94 0.56 2.01e-53 Neutrophil percentage of white cells; BRCA cis rs17401966 1.000 rs11121552 chr1:10435324 C/A cg03954927 chr1:10346856 KIF1B 0.46 12.58 0.45 1.39e-32 Hepatocellular carcinoma; BRCA cis rs4988958 0.565 rs12712146 chr2:103008714 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.21e-16 Asthma (childhood onset); BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.67 -13.53 -0.47 7.38e-37 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg24829409 chr8:58192753 C8orf71 -0.59 -12.29 -0.44 2.57e-31 Developmental language disorder (linguistic errors); BRCA cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg05025164 chr4:1340916 KIAA1530 0.4 8.94 0.33 3.99e-18 Longevity; BRCA cis rs17270561 0.608 rs9358875 chr6:25738008 G/A cg17691542 chr6:26056736 HIST1H1C 0.46 8.87 0.33 7.29e-18 Iron status biomarkers; BRCA cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.17 -0.4 1.33e-26 Schizophrenia; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg22907277 chr7:1156413 C7orf50 0.5 10.91 0.4 1.5e-25 Longevity;Endometriosis; BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00149659 chr3:10157352 C3orf10 0.69 10.32 0.38 3.26e-23 Alzheimer's disease; BRCA cis rs7124681 0.584 rs11039448 chr11:47918416 G/T cg20307385 chr11:47447363 PSMC3 -0.41 -9.36 -0.35 1.37e-19 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs2011503 0.941 rs56044734 chr19:19366927 G/A cg11584989 chr19:19387371 SF4 0.61 13.9 0.48 1.5e-38 Bipolar disorder; BRCA trans rs4718428 0.924 rs6971897 chr7:66412774 T/A cg18876405 chr7:65276391 NA 0.45 10.01 0.37 5.43e-22 Corneal structure; BRCA cis rs490234 0.871 rs13288032 chr9:128255582 T/A cg14078157 chr9:128172775 NA -0.43 -9.93 -0.37 1.01e-21 Mean arterial pressure; BRCA trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg18196295 chr10:418757 DIP2C 0.41 9.48 0.35 4.96e-20 Psychosis in Alzheimer's disease; BRCA cis rs7818345 0.967 rs4433156 chr8:19284247 A/C cg11303988 chr8:19266685 CSGALNACT1 0.3 7.96 0.3 7.89e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs6604026 0.698 rs10874744 chr1:93306317 G/A cg17283838 chr1:93427260 FAM69A -0.39 -8.23 -0.31 1.03e-15 Multiple sclerosis; BRCA trans rs208520 0.690 rs207102 chr6:66795671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs1401999 0.966 rs4148585 chr3:183670642 A/G cg01324343 chr3:183735012 ABCC5 0.83 20.87 0.64 3.89e-74 Anterior chamber depth; BRCA cis rs4975616 0.714 rs37007 chr5:1352372 G/C cg26373071 chr5:1325741 CLPTM1L 0.41 9.55 0.35 2.72e-20 Lung cancer; BRCA cis rs9859260 0.744 rs492349 chr3:195784192 G/A cg12923728 chr3:195709715 SDHAP1 0.38 7.83 0.3 2.01e-14 Mean corpuscular volume; BRCA cis rs11887277 0.507 rs6547254 chr2:27055618 G/A cg12368169 chr2:27073192 DPYSL5 -0.27 -8.01 -0.3 5.28e-15 Obesity-related traits; BRCA cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg24812749 chr6:127587940 RNF146 0.86 19.78 0.62 2.55e-68 Breast cancer; BRCA cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7818345 0.967 rs11204039 chr8:19280442 A/C cg11303988 chr8:19266685 CSGALNACT1 0.3 8.08 0.3 3.19e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.03 -0.4 5.04e-26 Lymphocyte counts; BRCA trans rs3733585 0.781 rs13103690 chr4:9972778 T/G cg26043149 chr18:55253948 FECH -0.4 -8.99 -0.34 2.68e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs72848980 0.512 rs11191749 chr10:105378840 A/G cg00126946 chr10:105363258 SH3PXD2A 0.45 8.77 0.33 1.59e-17 White matter hyperintensity burden; BRCA cis rs312273 0.641 rs7311085 chr12:41361565 G/A cg17827154 chr12:41323612 CNTN1 -0.36 -9.32 -0.35 1.82e-19 Bipolar disorder; BRCA cis rs2880765 0.743 rs11630410 chr15:86004741 T/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.14 -0.31 2.01e-15 Coronary artery disease; BRCA cis rs10751667 0.643 rs11246344 chr11:933783 A/C ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.21e-47 Alzheimer's disease (late onset); BRCA cis rs798554 0.671 rs1182195 chr7:2868730 A/G cg19717773 chr7:2847554 GNA12 -0.42 -8.62 -0.32 5.3e-17 Height; BRCA cis rs61612642 0.523 rs59004693 chr6:42157392 G/A cg01092361 chr6:42185687 MRPS10 0.7 13.29 0.47 9.42e-36 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs11122272 0.638 rs2739514 chr1:231514806 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.47 -11.18 -0.4 1.21e-26 Hemoglobin concentration; BRCA cis rs7927592 0.913 rs66752716 chr11:68273626 C/T cg20283391 chr11:68216788 NA -0.48 -9.31 -0.35 2.06e-19 Total body bone mineral density; BRCA cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg21782813 chr7:2030301 MAD1L1 0.38 9.67 0.36 9.77e-21 Bipolar disorder and schizophrenia; BRCA cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg06022373 chr22:39101656 GTPBP1 0.73 18.11 0.58 1.89e-59 Menopause (age at onset); BRCA cis rs12188164 0.543 rs2434695 chr5:464177 C/G cg26850624 chr5:429559 AHRR 0.35 8.36 0.31 4.02e-16 Cystic fibrosis severity; BRCA cis rs1506636 1.000 rs659416 chr7:123401764 A/G cg03229431 chr7:123269106 ASB15 -0.61 -13.64 -0.47 2.2e-37 Plateletcrit;Platelet count; BRCA trans rs11098499 0.954 rs67265404 chr4:120359270 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.91 0.3 1.11e-14 Corneal astigmatism; BRCA cis rs72781680 0.611 rs74661620 chr2:24365260 C/A cg08917208 chr2:24149416 ATAD2B 0.52 7.82 0.3 2.2e-14 Lymphocyte counts; BRCA cis rs7809950 1.000 rs12668402 chr7:107173020 G/A cg23024343 chr7:107201750 COG5 -0.39 -9.03 -0.34 2.06e-18 Coronary artery disease; BRCA cis rs9296092 0.538 rs62407565 chr6:33535739 A/G cg13560919 chr6:33536144 NA -0.91 -19.57 -0.61 3.68e-67 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg17330251 chr7:94953956 PON1 -0.42 -8.85 -0.33 8.59e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9399135 0.660 rs4472368 chr6:135274232 A/G cg24558204 chr6:135376177 HBS1L 0.49 13.4 0.47 2.87e-36 Red blood cell count; BRCA cis rs7617773 1.000 rs12496784 chr3:48186267 C/T cg11946769 chr3:48343235 NME6 -0.4 -8.9 -0.33 5.7e-18 Coronary artery disease; BRCA cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg02503808 chr4:7069936 GRPEL1 0.79 17.75 0.57 1.26e-57 Monocyte percentage of white cells; BRCA cis rs7666738 0.546 rs10018080 chr4:98758436 C/A cg05340658 chr4:99064831 C4orf37 0.57 11.08 0.4 3.33e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 0.636 rs9379782 chr6:25715023 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.16 0.34 7.15e-19 Iron status biomarkers; BRCA cis rs1506636 1.000 rs619575 chr7:123393460 C/T cg03229431 chr7:123269106 ASB15 -0.49 -10.61 -0.39 2.57e-24 Plateletcrit;Platelet count; BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg22920501 chr2:26401640 FAM59B -0.63 -11.18 -0.4 1.2e-26 Gut microbiome composition (summer); BRCA trans rs7786808 0.505 rs67537656 chr7:158192646 C/T cg02030672 chr11:45687055 CHST1 -0.4 -9.03 -0.34 2.05e-18 Obesity-related traits; BRCA cis rs67311347 0.544 rs2887965 chr3:40334154 A/G cg09455208 chr3:40491958 NA -0.32 -7.85 -0.3 1.7e-14 Renal cell carcinoma; BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -21.83 -0.65 2.38e-79 Gut microbiome composition (summer); BRCA cis rs311392 0.902 rs448238 chr8:55093655 C/T cg11783602 chr8:55087084 NA 0.31 9.34 0.35 1.59e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs12701220 0.901 rs12701713 chr7:1090505 G/A cg02733842 chr7:1102375 C7orf50 -0.69 -12.88 -0.45 6.32e-34 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg05340658 chr4:99064831 C4orf37 0.63 15.08 0.51 3.66e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs4481887 1.000 rs6659039 chr1:248465689 C/T cg00666640 chr1:248458726 OR2T12 0.33 8.93 0.33 4.51e-18 Common traits (Other); BRCA cis rs9486719 1.000 rs6923212 chr6:97061940 A/G cg06623918 chr6:96969491 KIAA0776 -0.77 -14.0 -0.48 4.98e-39 Migraine;Coronary artery disease; BRCA cis rs4588572 0.643 rs10043115 chr5:77692019 T/C cg11547950 chr5:77652471 NA 0.46 8.34 0.31 4.46e-16 Triglycerides; BRCA cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.39 0.57 9.43e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.965 rs8131126 chr21:40655754 A/G cg11644478 chr21:40555479 PSMG1 0.74 15.13 0.51 2.08e-44 Cognitive function; BRCA cis rs6687430 0.526 rs12120962 chr1:10609505 G/A cg17425144 chr1:10567563 PEX14 0.56 12.96 0.46 2.71e-34 Hand grip strength; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -10.98 -0.4 7.86e-26 Longevity;Endometriosis; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.18 -0.31 1.5e-15 Total body bone mineral density; BRCA cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg00684032 chr4:1343700 KIAA1530 0.31 7.96 0.3 7.64e-15 Obesity-related traits; BRCA cis rs243505 0.528 rs6977453 chr7:148474746 A/G cg09806900 chr7:148480153 CUL1 0.54 11.03 0.4 5.18e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10046574 0.561 rs9656457 chr7:135202254 T/A cg27474649 chr7:135195673 CNOT4 0.67 11.09 0.4 3.01e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs27434 0.529 rs34757 chr5:96152588 T/C cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.24e-33 Ankylosing spondylitis; BRCA cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg04450456 chr4:17643702 FAM184B 0.39 11.62 0.42 1.88e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2712184 0.873 rs1548945 chr2:217665788 T/C cg05032264 chr2:217675019 NA -0.36 -8.55 -0.32 8.83e-17 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg04414720 chr1:150670196 GOLPH3L 0.37 8.42 0.32 2.43e-16 Tonsillectomy; BRCA cis rs897080 0.515 rs1067337 chr2:44624859 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.34 0.35 1.53e-19 Height; BRCA cis rs1577917 0.958 rs3857480 chr6:86535149 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.62 -0.42 1.85e-28 Response to antipsychotic treatment; BRCA trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg15556689 chr8:8085844 FLJ10661 -0.39 -9.82 -0.36 2.81e-21 Retinal vascular caliber; BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.84 0.42 2.32e-29 Tonsillectomy; BRCA cis rs11622475 1.000 rs34964872 chr14:104448435 T/A cg12183467 chr14:104352244 NA -0.5 -10.36 -0.38 2.36e-23 Bipolar disorder; BRCA trans rs11098499 0.909 rs28581362 chr4:120283548 T/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg02951883 chr7:2050386 MAD1L1 -0.62 -15.84 -0.53 6.82e-48 Bipolar disorder and schizophrenia; BRCA cis rs17253792 0.822 rs76555508 chr14:56071868 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.6 8.13 0.31 2.23e-15 Putamen volume; BRCA cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg05347473 chr6:146136440 FBXO30 -0.39 -7.87 -0.3 1.57e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg12310025 chr6:25882481 NA -0.42 -9.97 -0.37 7.67e-22 Height; BRCA cis rs17376456 0.877 rs13169675 chr5:93331284 A/G cg21475434 chr5:93447410 FAM172A 0.68 8.62 0.32 5.37e-17 Diabetic retinopathy; BRCA cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.47 0.5 2.93e-41 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836974 0.568 rs442972 chr21:40534757 C/T cg11890956 chr21:40555474 PSMG1 -0.85 -21.98 -0.66 3.35e-80 Cognitive function; BRCA cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg06784218 chr1:46089804 CCDC17 0.44 10.66 0.39 1.59e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3820928 0.904 rs60906902 chr2:227760034 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.41 -0.32 2.76e-16 Pulmonary function; BRCA trans rs12517041 1.000 rs4701362 chr5:23300849 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.47 -7.96 -0.3 8.09e-15 Calcium levels; BRCA cis rs453301 0.686 rs6748 chr8:8890802 C/T cg15556689 chr8:8085844 FLJ10661 -0.31 -8.22 -0.31 1.1e-15 Joint mobility (Beighton score); BRCA cis rs11608355 0.545 rs2302705 chr12:109898716 C/T cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs2204008 0.694 rs1672436 chr12:38132547 G/T cg26384229 chr12:38710491 ALG10B -0.46 -10.57 -0.39 3.71e-24 Bladder cancer; BRCA cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg14728415 chr7:32535168 LSM5;AVL9 -0.38 -8.4 -0.32 2.93e-16 Cognitive ability; BRCA cis rs2839186 0.786 rs7409792 chr21:47691729 C/A cg12379764 chr21:47803548 PCNT -0.38 -8.32 -0.31 5.19e-16 Testicular germ cell tumor; BRCA cis rs6684514 1.000 rs12139321 chr1:156230429 A/G cg16558208 chr1:156270281 VHLL 0.37 8.24 0.31 9.85e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9291683 0.597 rs11723016 chr4:10126189 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -10.75 -0.39 6.89e-25 Bone mineral density; BRCA trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.04e-18 Morning vs. evening chronotype; BRCA cis rs3768617 0.510 rs10911243 chr1:183075415 G/A ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.43e-58 Fuchs's corneal dystrophy; BRCA cis rs2108225 0.837 rs6958729 chr7:107451211 A/G cg18560240 chr7:107437656 SLC26A3 0.53 11.18 0.4 1.3e-26 Ulcerative colitis; BRCA cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg24642439 chr20:33292090 TP53INP2 0.71 16.3 0.54 3.23e-50 Coronary artery disease; BRCA cis rs4076764 0.801 rs4571944 chr1:163367975 T/C cg24596788 chr1:163392923 NA -0.35 -9.4 -0.35 9.75e-20 Motion sickness; BRCA cis rs10779751 0.734 rs1148485 chr1:11148759 G/A cg08854313 chr1:11322531 MTOR 0.74 14.28 0.49 2.48e-40 Body mass index; BRCA cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.69 12.84 0.45 9.69e-34 Lung function (FEV1/FVC); BRCA cis rs3820928 0.874 rs2177594 chr2:227836239 C/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.33 -0.31 5.03e-16 Pulmonary function; BRCA cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs897080 0.552 rs1067365 chr2:44655398 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.35 0.35 1.44e-19 Height; BRCA cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg23711669 chr6:146136114 FBXO30 0.74 17.77 0.58 1.06e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs12474201 0.832 rs6738426 chr2:46986416 A/G cg06386533 chr2:46925753 SOCS5 0.84 18.19 0.58 7.22e-60 Height; BRCA cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg06970220 chr1:156163860 SLC25A44 0.39 9.46 0.35 5.77e-20 Testicular germ cell tumor; BRCA cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg21138405 chr5:131827807 IRF1 -0.37 -11.6 -0.42 2.3e-28 Asthma (sex interaction); BRCA trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs244731 0.959 rs918459 chr5:176669030 C/T cg17509989 chr5:176798049 RGS14 -0.73 -12.05 -0.43 2.75e-30 Urate levels in lean individuals; BRCA cis rs1595825 0.891 rs2045244 chr2:198506466 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -8.59 -0.32 6.53e-17 Ulcerative colitis; BRCA cis rs9394152 0.845 rs9394153 chr6:33471630 A/C cg13560919 chr6:33536144 NA 0.62 12.76 0.45 2.26e-33 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7903847 0.642 rs10882910 chr10:99138043 G/A cg08345082 chr10:99160200 RRP12 -0.29 -8.51 -0.32 1.24e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs13046373 0.507 rs2832969 chr21:32019627 A/G cg22337977 chr21:31811175 KRTAP15-1 0.33 7.88 0.3 1.42e-14 HDL cholesterol; BRCA cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg24450063 chr1:156163899 SLC25A44 1.12 36.13 0.82 1.49e-156 Testicular germ cell tumor; BRCA cis rs10504229 1.000 rs59797486 chr8:58174435 T/C cg14926445 chr8:58193284 C8orf71 -0.44 -8.74 -0.33 2.01e-17 Developmental language disorder (linguistic errors); BRCA cis rs2239547 0.522 rs2710345 chr3:52976075 T/C cg11645453 chr3:52864694 ITIH4 -0.46 -11.58 -0.42 2.79e-28 Schizophrenia; BRCA cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.59 8.64 0.32 4.37e-17 Initial pursuit acceleration; BRCA cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.62 13.17 0.46 3.37e-35 Age-related macular degeneration (geographic atrophy); BRCA cis rs4319547 0.728 rs61954974 chr12:123074169 T/C cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.94 -0.37 9.99e-22 Body mass index; BRCA cis rs7914558 1.000 rs1926030 chr10:104855656 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.78 0.39 5.3e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg21475434 chr5:93447410 FAM172A 0.66 8.66 0.32 3.97e-17 Diabetic retinopathy; BRCA cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg25801113 chr15:45476975 SHF 0.31 7.93 0.3 9.92e-15 Uric acid levels; BRCA cis rs9868809 0.881 rs13324142 chr3:48669447 C/T cg00383909 chr3:49044727 WDR6 0.48 7.85 0.3 1.77e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs11229555 0.874 rs11229512 chr11:58286105 T/C cg15696309 chr11:58395628 NA -0.53 -11.43 -0.41 1.15e-27 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs614226 1.000 rs541126 chr12:120972396 C/T cg01236616 chr12:121019343 POP5 -1.24 -24.95 -0.7 1.93e-96 Type 1 diabetes nephropathy; BRCA cis rs7772486 0.790 rs9497435 chr6:146265340 C/A cg23711669 chr6:146136114 FBXO30 -0.67 -15.75 -0.53 1.92e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.686 rs1292337 chr6:145967807 A/G cg23711669 chr6:146136114 FBXO30 -0.71 -17.19 -0.56 1.03e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6456156 0.565 rs7750209 chr6:167482895 T/G cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs7666738 0.830 rs28867388 chr4:98962794 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.46 0.38 9.36e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs208520 0.661 rs150263 chr6:66777620 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.09 -0.64 2.28e-75 Exhaled nitric oxide output; BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg21143896 chr7:2802374 GNA12 -0.35 -8.96 -0.33 3.5e-18 Height; BRCA cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg22875332 chr1:76189707 ACADM 0.5 9.85 0.36 2.01e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17253792 0.822 rs78261053 chr14:56061784 C/T cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg15556689 chr8:8085844 FLJ10661 -0.4 -10.59 -0.39 3.01e-24 Monocyte count; BRCA cis rs13095912 1.000 rs13100229 chr3:185343200 C/T cg11274856 chr3:185301563 NA 0.33 8.3 0.31 6.37e-16 Systolic blood pressure; BRCA cis rs17539620 0.624 rs62432746 chr6:154838986 A/G cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs7524258 0.900 rs7544004 chr1:7314529 A/C cg07173049 chr1:7289937 CAMTA1 0.38 9.7 0.36 7.54e-21 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs10464366 0.571 rs13233049 chr7:39187536 C/T cg18850127 chr7:39170497 POU6F2 0.54 11.91 0.43 1.15e-29 IgG glycosylation; BRCA cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.94 0.4 1.21e-25 Bipolar disorder; BRCA cis rs17384381 0.953 rs12717763 chr1:85808164 A/T cg16011679 chr1:85725395 C1orf52 0.54 8.31 0.31 5.69e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs6598955 0.617 rs11247883 chr1:26576247 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg18479299 chr3:125709523 NA -0.56 -8.79 -0.33 1.41e-17 Blood pressure (smoking interaction); BRCA cis rs17685 0.784 rs1613890 chr7:75735037 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.57 -0.32 7.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2762353 0.779 rs6905614 chr6:25840485 G/T cg12310025 chr6:25882481 NA -0.49 -12.1 -0.43 1.65e-30 Blood metabolite levels; BRCA cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg26395211 chr5:140044315 WDR55 0.38 8.69 0.32 3.11e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs3806843 0.966 rs2563265 chr5:140137005 C/T cg16179182 chr5:140090404 VTRNA1-1 0.42 9.95 0.37 8.84e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs2559856 0.935 rs2559864 chr12:102084710 C/G cg12213457 chr12:102090980 CHPT1 -0.37 -7.97 -0.3 7.1e-15 Blood protein levels; BRCA trans rs2204008 0.665 rs11495668 chr12:38221018 C/T cg06521331 chr12:34319734 NA -0.54 -9.78 -0.36 3.7e-21 Bladder cancer; BRCA cis rs7953249 0.807 rs2393791 chr12:121423956 A/G cg02403541 chr12:121454288 C12orf43 0.4 7.93 0.3 9.92e-15 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs17092148 0.836 rs4564863 chr20:33179367 T/C cg16810054 chr20:33298113 TP53INP2 -0.47 -10.67 -0.39 1.46e-24 Neuroticism; BRCA cis rs752010 0.543 rs7545381 chr1:42044183 T/A cg06885757 chr1:42089581 HIVEP3 0.22 8.13 0.31 2.17e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg00531865 chr16:30841666 NA -0.52 -12.13 -0.43 1.29e-30 Multiple myeloma; BRCA trans rs7615952 0.512 rs11929125 chr3:125359443 G/A cg07211511 chr3:129823064 LOC729375 -0.58 -10.64 -0.39 1.84e-24 Blood pressure (smoking interaction); BRCA cis rs778371 0.676 rs921055 chr2:233697337 A/C cg08000102 chr2:233561755 GIGYF2 -0.78 -16.62 -0.55 8.38e-52 Schizophrenia; BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs523522 0.962 rs4767904 chr12:120930798 T/G cg27279351 chr12:120934652 DYNLL1 0.51 12.33 0.44 1.68e-31 High light scatter reticulocyte count; BRCA cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg24110177 chr3:50126178 RBM5 0.47 12.22 0.44 5.19e-31 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs7608498 chr2:10738428 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs826838 0.585 rs4363678 chr12:38624514 G/A cg26384229 chr12:38710491 ALG10B 0.43 10.45 0.38 1.1e-23 Heart rate; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg11814155 chr7:99998594 ZCWPW1 0.53 8.98 0.33 2.9e-18 Platelet count; BRCA trans rs7799006 0.527 rs73039284 chr7:2221583 C/G cg04565464 chr8:145669602 NFKBIL2 0.36 7.99 0.3 6.23e-15 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7727544 0.642 rs7705189 chr5:131623358 C/T cg14196790 chr5:131705035 SLC22A5 -0.39 -10.2 -0.37 9.61e-23 Blood metabolite levels; BRCA cis rs7408868 1.000 rs4809030 chr19:15273381 A/G cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg08975724 chr8:8085496 FLJ10661 0.44 9.81 0.36 2.93e-21 Mood instability; BRCA trans rs9929218 0.817 rs8055912 chr16:68802068 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -13.85 -0.48 2.54e-38 Colorectal cancer; BRCA cis rs2777491 0.957 rs6493002 chr15:41709195 C/G cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.39 -0.54 1.2e-50 Ulcerative colitis; BRCA cis rs701145 0.537 rs1713832 chr3:153835833 C/T cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.89e-18 Coronary artery disease; BRCA cis rs1351164 0.947 rs57004880 chr2:218272581 A/C cg15335768 chr2:218268053 DIRC3 -0.34 -8.48 -0.32 1.53e-16 Height; BRCA cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg03433033 chr1:76189801 ACADM 0.68 13.64 0.47 2.34e-37 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs514406 0.565 rs897732 chr1:53382816 A/C cg01802117 chr1:53393560 SCP2 -0.42 -9.48 -0.35 5.06e-20 Monocyte count; BRCA cis rs495337 1.000 rs2235616 chr20:48569127 G/A cg17835207 chr20:48524531 SPATA2 -0.58 -13.05 -0.46 1.1e-34 Psoriasis; BRCA cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg05868516 chr6:26286170 HIST1H4H 0.5 11.05 0.4 4.41e-26 Educational attainment; BRCA cis rs2070488 0.689 rs6809352 chr3:38544349 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.57 -14.94 -0.51 1.6e-43 Electrocardiographic conduction measures; BRCA cis rs7809950 0.599 rs2237658 chr7:106837866 T/G cg23024343 chr7:107201750 COG5 -0.43 -8.8 -0.33 1.3e-17 Coronary artery disease; BRCA cis rs2346177 0.519 rs1597040 chr2:46673903 C/T cg06386533 chr2:46925753 SOCS5 0.43 8.09 0.3 3.03e-15 HDL cholesterol; BRCA cis rs11874712 1.000 rs11082510 chr18:43656620 T/A cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.01 0.3 5.44e-15 Migraine - clinic-based; BRCA cis rs11828289 0.607 rs76811253 chr11:23222885 G/A cg20040320 chr11:23191996 NA -0.53 -7.81 -0.3 2.37e-14 Cancer; BRCA cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.53 -0.32 1.08e-16 Aortic root size; BRCA cis rs477692 0.905 rs7905466 chr10:131438937 A/T cg05714579 chr10:131428358 MGMT -0.5 -11.9 -0.43 1.28e-29 Response to temozolomide; BRCA cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg14829155 chr15:31115871 NA -0.42 -9.85 -0.36 2.03e-21 Huntington's disease progression; BRCA cis rs6840360 0.593 rs4696106 chr4:152606818 A/G cg22705602 chr4:152727874 NA -0.38 -10.3 -0.38 4.15e-23 Intelligence (multi-trait analysis); BRCA cis rs9790314 1.000 rs336590 chr3:161079583 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.36 -0.49 1.02e-40 Morning vs. evening chronotype; BRCA cis rs7617773 0.780 rs77044321 chr3:48349314 C/T cg11946769 chr3:48343235 NME6 0.69 13.89 0.48 1.68e-38 Coronary artery disease; BRCA cis rs4363385 0.755 rs516198 chr1:153026196 T/C cg24667326 chr1:152973720 SPRR3 -0.31 -8.28 -0.31 7.43e-16 Inflammatory skin disease; BRCA cis rs4594175 0.926 rs12101170 chr14:51611902 T/C cg23942311 chr14:51606299 NA 0.32 7.81 0.3 2.41e-14 Cancer; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg23708337 chr7:1209742 NA 0.54 11.6 0.42 2.32e-28 Longevity;Endometriosis; BRCA cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.7 -0.55 3.21e-52 Extrinsic epigenetic age acceleration; BRCA cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg06618935 chr21:46677482 NA -0.37 -7.94 -0.3 9e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg19539972 chr4:7069911 GRPEL1 -0.63 -12.18 -0.43 7.9e-31 Monocyte percentage of white cells; BRCA cis rs2153535 0.580 rs1889715 chr6:8443475 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.49e-23 Motion sickness; BRCA trans rs11250098 0.574 rs4240672 chr8:10767917 G/A cg06636001 chr8:8085503 FLJ10661 -0.43 -8.89 -0.33 6.15e-18 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs28444709 chr4:99028496 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 9.01e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 1.000 rs2297284 chr21:46705345 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.75 14.87 0.51 3.5e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg00701064 chr4:6280414 WFS1 0.6 15.32 0.52 2.35e-45 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs55883249 1.000 rs55883249 chr2:9741535 C/A cg23886495 chr2:9695866 ADAM17 0.55 7.95 0.3 8.39e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs10193935 0.901 rs12622153 chr2:42598386 C/A cg27598129 chr2:42591480 NA -0.86 -14.41 -0.5 5.89e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs16910800 0.689 rs4491218 chr11:23163977 G/A cg20040320 chr11:23191996 NA -0.57 -9.2 -0.34 5.11e-19 Cancer; BRCA cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg08859206 chr1:53392774 SCP2 0.48 10.51 0.38 6.23e-24 Monocyte count; BRCA cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg08000102 chr2:233561755 GIGYF2 0.61 13.06 0.46 1.02e-34 Coronary artery disease; BRCA cis rs7927592 0.913 rs10896346 chr11:68352671 C/T cg20283391 chr11:68216788 NA -0.45 -8.93 -0.33 4.39e-18 Total body bone mineral density; BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg03709012 chr19:19516395 GATAD2A -0.8 -18.33 -0.59 1.2e-60 Tonsillectomy; BRCA cis rs4906332 1.000 rs2065015 chr14:103904061 G/T cg19000871 chr14:103996768 TRMT61A 0.34 7.84 0.3 1.83e-14 Coronary artery disease; BRCA cis rs7772486 0.790 rs2247666 chr6:146220409 C/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.35 -0.35 1.49e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7917772 0.503 rs56397707 chr10:104302693 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.33 0.59 1.31e-60 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg00409905 chr10:38381863 ZNF37A 0.49 10.62 0.39 2.31e-24 Extrinsic epigenetic age acceleration; BRCA cis rs2066819 0.892 rs117305040 chr12:56657888 A/G cg26734620 chr12:56694298 CS 0.92 10.64 0.39 1.83e-24 Psoriasis vulgaris; BRCA cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg13010199 chr12:38710504 ALG10B 0.42 8.48 0.32 1.54e-16 Bladder cancer; BRCA cis rs6582630 0.638 rs1829584 chr12:38526299 G/T cg26384229 chr12:38710491 ALG10B -0.45 -10.3 -0.38 3.9699999999999997e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs6426558 0.537 rs689094 chr1:227308909 G/A cg10327440 chr1:227177885 CDC42BPA 0.47 9.31 0.35 2.09e-19 Neutrophil percentage of white cells; BRCA trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21665057 chr3:196295764 WDR53;FBXO45 0.35 8.51 0.32 1.25e-16 Resting heart rate; BRCA cis rs4268898 0.662 rs59996104 chr2:24404064 C/T cg06627628 chr2:24431161 ITSN2 -0.82 -14.83 -0.51 5.87e-43 Asthma; BRCA cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg12292205 chr6:26970375 C6orf41 -0.8 -19.68 -0.61 9.64e-68 Autism spectrum disorder or schizophrenia; BRCA cis rs3771570 1.000 rs56383420 chr2:242219281 A/G cg21155796 chr2:242212141 HDLBP 0.62 9.76 0.36 4.48e-21 Prostate cancer; BRCA cis rs10189230 0.643 rs2710503 chr2:222374699 C/G cg14652038 chr2:222343519 EPHA4 -0.33 -8.03 -0.3 4.57e-15 Urate levels in lean individuals; BRCA cis rs1801251 0.727 rs283482 chr2:233646920 A/T cg08000102 chr2:233561755 GIGYF2 0.64 14.45 0.5 3.91e-41 Coronary artery disease; BRCA cis rs4787491 0.729 rs4788213 chr16:30034524 T/C cg06326092 chr16:30034487 C16orf92 0.38 9.93 0.37 1.07e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11252926 0.732 rs10904541 chr10:744008 A/G cg08603382 chr10:743973 NA -0.53 -10.28 -0.38 4.93e-23 Psychosis in Alzheimer's disease; BRCA cis rs1420338 0.867 rs7795950 chr7:34161715 A/G cg01275685 chr7:34179230 BMPER -0.46 -10.19 -0.37 1.03e-22 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9287719 0.967 rs6735074 chr2:10734766 G/T cg00105475 chr2:10696890 NA -0.43 -10.04 -0.37 4.11e-22 Prostate cancer; BRCA cis rs66887589 0.934 rs2715016 chr4:120452356 T/C cg09307838 chr4:120376055 NA -0.43 -8.74 -0.33 2.13e-17 Diastolic blood pressure; BRCA cis rs11229555 0.645 rs11229427 chr11:58180275 A/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg14926445 chr8:58193284 C8orf71 -0.44 -8.46 -0.32 1.77e-16 Developmental language disorder (linguistic errors); BRCA cis rs6684428 0.610 rs12120132 chr1:56322054 G/A cg11651538 chr1:56320950 NA -0.44 -7.81 -0.3 2.39e-14 Airflow obstruction; BRCA cis rs4988958 0.527 rs3771155 chr2:103037826 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.33 0.31 5.08e-16 Asthma (childhood onset); BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 11.17 0.4 1.41e-26 Platelet count; BRCA cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg21535247 chr6:8435926 SLC35B3 0.39 8.94 0.33 4.23e-18 Motion sickness; BRCA cis rs2066819 1.000 rs75754909 chr12:56726349 A/G cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg12641515 chr19:46296257 DMWD -0.56 -12.56 -0.45 1.64e-32 Coronary artery disease; BRCA cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.27e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17384381 1.000 rs12138852 chr1:85878208 C/T cg16011679 chr1:85725395 C1orf52 0.52 8.08 0.3 3.13e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.94e-30 Tonsillectomy; BRCA cis rs17253792 0.822 rs76918910 chr14:56058762 T/C cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs208520 1.000 rs12216109 chr6:66987488 C/G cg07460842 chr6:66804631 NA 0.88 14.18 0.49 7.35e-40 Exhaled nitric oxide output; BRCA cis rs6963495 0.745 rs55906043 chr7:105165367 T/G cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs910873 0.505 rs2378249 chr20:33218090 G/A cg16810054 chr20:33298113 TP53INP2 -0.47 -10.41 -0.38 1.57e-23 Melanoma; BRCA cis rs12760731 0.565 rs57247289 chr1:178090138 G/A cg00404053 chr1:178313656 RASAL2 0.62 7.92 0.3 1.09e-14 Obesity-related traits; BRCA trans rs11098499 0.575 rs907205 chr4:120238664 G/C cg25214090 chr10:38739885 LOC399744 0.45 10.3 0.38 4.19e-23 Corneal astigmatism; BRCA cis rs2180341 1.000 rs4897207 chr6:127605898 C/T cg27446573 chr6:127587934 RNF146 0.88 20.81 0.64 8.36e-74 Breast cancer; BRCA cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs778371 0.697 rs2344611 chr2:233581937 A/G cg08000102 chr2:233561755 GIGYF2 0.78 17.01 0.56 8.2e-54 Schizophrenia; BRCA cis rs7833986 0.501 rs2719259 chr8:56941630 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.67 13.11 0.46 5.97e-35 Height; BRCA cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg06640241 chr16:89574553 SPG7 0.85 21.33 0.64 1.17e-76 Multiple myeloma (IgH translocation); BRCA cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg09035930 chr12:129282057 SLC15A4 0.49 13.77 0.48 5.5e-38 Systemic lupus erythematosus; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg20607798 chr8:58055168 NA 0.47 8.09 0.3 3.07e-15 Developmental language disorder (linguistic errors); BRCA cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg16006841 chr5:176797999 RGS14 -0.89 -17.17 -0.56 1.23e-54 Hemoglobin concentration;Hematocrit; BRCA cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg24642439 chr20:33292090 TP53INP2 0.54 11.72 0.42 7.07e-29 Glomerular filtration rate (creatinine); BRCA cis rs561341 1.000 rs530209 chr17:30315287 A/G cg23018236 chr17:30244563 NA -0.62 -10.14 -0.37 1.72e-22 Hip circumference adjusted for BMI; BRCA cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.64 -0.39 1.88e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11471957 1 rs11471957 chr20:57598332 C/CAA cg14073986 chr20:57617431 SLMO2 0.5 8.25 0.31 9.06e-16 Platelet count;Mean platelet volume; BRCA trans rs34421088 0.576 rs2572432 chr8:11101723 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -8.16 -0.31 1.84e-15 Neuroticism; BRCA cis rs7903847 0.642 rs11189178 chr10:99143272 T/G cg08345082 chr10:99160200 RRP12 -0.3 -8.67 -0.32 3.61e-17 Granulocyte percentage of myeloid white cells; BRCA trans rs1459104 1.000 rs2903534 chr11:55054044 A/G cg15704280 chr7:45808275 SEPT13 0.7 8.71 0.33 2.57e-17 Body mass index; BRCA cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg08999081 chr20:33150536 PIGU 0.47 13.11 0.46 6.3e-35 Glomerular filtration rate (creatinine); BRCA cis rs7927592 0.913 rs6591340 chr11:68297636 A/G cg20283391 chr11:68216788 NA -0.48 -9.33 -0.35 1.65e-19 Total body bone mineral density; BRCA cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg05347473 chr6:146136440 FBXO30 0.4 8.0 0.3 5.87e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg18876405 chr7:65276391 NA 0.7 18.57 0.59 6.72e-62 Calcium levels; BRCA cis rs757110 0.740 rs10832776 chr11:17385224 C/A cg15432903 chr11:17409602 KCNJ11 0.71 15.42 0.52 8.06e-46 Type 2 diabetes; BRCA trans rs11098499 0.722 rs28713555 chr4:120251995 C/T cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.45e-23 Corneal astigmatism; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg16145915 chr7:1198662 ZFAND2A -0.58 -13.96 -0.48 7.69e-39 Longevity;Endometriosis; BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.11 0.67 2.5e-86 Platelet count; BRCA cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg10560079 chr2:191398806 TMEM194B -0.36 -8.01 -0.3 5.4e-15 Pulse pressure; BRCA cis rs2073300 0.609 rs6137931 chr20:23376875 G/C cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.43e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs9291683 0.546 rs4575994 chr4:9997979 G/A cg26043149 chr18:55253948 FECH 0.38 8.22 0.31 1.15e-15 Bone mineral density; BRCA cis rs208520 1.000 rs12190773 chr6:66968194 T/C cg07460842 chr6:66804631 NA 0.87 14.42 0.5 5.11e-41 Exhaled nitric oxide output; BRCA cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -16.99 -0.56 1.06e-53 Chronic sinus infection; BRCA cis rs4689388 0.890 rs13130845 chr4:6297646 A/C cg25554036 chr4:6271136 WFS1 0.41 9.44 0.35 6.67e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg13073564 chr4:8508604 NA 0.46 12.29 0.44 2.61e-31 Response to antineoplastic agents; BRCA trans rs11039798 1.000 rs7924372 chr11:48556319 T/A cg15704280 chr7:45808275 SEPT13 0.68 8.19 0.31 1.44e-15 Axial length; BRCA trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.92 -0.56 2.36e-53 Intelligence (multi-trait analysis); BRCA cis rs4865169 0.691 rs1056364 chr4:57889677 C/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.31 -7.97 -0.3 7.54e-15 Breast cancer; BRCA cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg14061069 chr19:46274453 DMPK -0.49 -12.06 -0.43 2.67e-30 Coronary artery disease; BRCA cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg10578991 chr7:12443926 VWDE -0.52 -7.94 -0.3 9.11e-15 Coronary artery disease; BRCA cis rs11191205 0.644 rs12354716 chr10:103386775 C/A cg15320455 chr10:103880129 LDB1 0.46 7.85 0.3 1.72e-14 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.545 rs17546375 chr12:39407248 C/A cg26384229 chr12:38710491 ALG10B 0.52 11.12 0.4 2.28e-26 Morning vs. evening chronotype; BRCA cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg06671706 chr8:8559999 CLDN23 -0.42 -8.14 -0.31 2.05e-15 Obesity-related traits; BRCA cis rs1577917 1.000 rs6936048 chr6:86702608 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.03 -0.43 3.59e-30 Response to antipsychotic treatment; BRCA trans rs11039798 0.841 rs12221667 chr11:48548549 G/T cg15704280 chr7:45808275 SEPT13 0.68 8.22 0.31 1.12e-15 Axial length; BRCA cis rs9443189 0.570 rs9343316 chr6:76411800 G/A cg01950844 chr6:76311363 SENP6 0.84 13.57 0.47 5.09e-37 Prostate cancer; BRCA cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs78487399 0.908 rs17031088 chr2:43807090 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.52 -8.06 -0.3 3.72e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.03 -0.4 5.24e-26 Extrinsic epigenetic age acceleration; BRCA cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg21573476 chr21:45109991 RRP1B -0.34 -8.61 -0.32 5.7e-17 Mean corpuscular volume; BRCA cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.6 13.27 0.46 1.17e-35 Hemoglobin concentration; BRCA cis rs13108904 0.539 rs13141992 chr4:1340765 C/T cg13395646 chr4:1353034 KIAA1530 -0.51 -9.17 -0.34 6.26e-19 Obesity-related traits; BRCA cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.82 -0.33 1.11e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.16 0.56 1.47e-54 Bladder cancer; BRCA cis rs67478160 0.608 rs34066659 chr14:104263427 A/C cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.37 -0.41 2.06e-27 Schizophrenia; BRCA cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.68 -0.5 2.95e-42 Chronic sinus infection; BRCA cis rs11249608 0.789 rs7700958 chr5:178436617 G/A cg21905437 chr5:178450457 ZNF879 0.48 9.68 0.36 9.38e-21 Pubertal anthropometrics; BRCA cis rs9486715 1.000 rs9373985 chr6:97063522 C/G cg06623918 chr6:96969491 KIAA0776 -0.82 -22.04 -0.66 1.78e-80 Headache; BRCA trans rs11098499 0.954 rs59866101 chr4:120296591 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs12477438 0.765 rs1453564 chr2:99564428 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.21 -0.43 5.87e-31 Chronic sinus infection; BRCA cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.2 0.49 5.86e-40 Motion sickness; BRCA cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -8.07 -0.3 3.44e-15 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs936229 0.690 rs2472300 chr15:75033909 A/G cg14664628 chr15:75095509 CSK -0.84 -22.43 -0.66 1.3e-82 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg22920501 chr2:26401640 FAM59B 0.91 15.61 0.53 9.09e-47 Gut microbiome composition (summer); BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg00149659 chr3:10157352 C3orf10 -0.65 -9.87 -0.36 1.79e-21 Alzheimer's disease; BRCA cis rs11098499 0.691 rs9307471 chr4:120261262 G/A cg09307838 chr4:120376055 NA 0.58 12.69 0.45 4.73e-33 Corneal astigmatism; BRCA cis rs2070997 0.607 rs3808821 chr9:133712801 G/T cg11464064 chr9:133710261 ABL1 -0.49 -9.16 -0.34 6.73e-19 Response to amphetamines; BRCA cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg10523679 chr1:76189770 ACADM -0.46 -8.91 -0.33 5.27e-18 Daytime sleep phenotypes; BRCA cis rs55794721 0.509 rs873308 chr1:25758655 A/G cg27572855 chr1:25598939 RHD -0.44 -12.4 -0.44 8.9e-32 Plateletcrit;Mean corpuscular volume; BRCA cis rs9653442 0.648 rs11123805 chr2:100643464 A/G cg22139774 chr2:100720529 AFF3 -0.29 -8.13 -0.31 2.3e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs5758659 0.652 rs133323 chr22:42405922 T/C cg15557168 chr22:42548783 NA -0.31 -8.64 -0.32 4.39e-17 Cognitive function; BRCA cis rs17253792 0.822 rs2274075 chr14:56096731 A/G cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs2204008 0.807 rs10880234 chr12:38318353 C/T cg26384229 chr12:38710491 ALG10B 0.73 16.02 0.54 8.33e-49 Bladder cancer; BRCA cis rs9291683 0.588 rs12507330 chr4:10002195 G/A cg02734326 chr4:10020555 SLC2A9 0.36 8.2 0.31 1.31e-15 Bone mineral density; BRCA cis rs17401966 0.838 rs946503 chr1:10308631 C/G cg03954927 chr1:10346856 KIF1B -0.4 -12.41 -0.44 7.51e-32 Hepatocellular carcinoma; BRCA cis rs12369179 1.000 rs12369179 chr12:122963550 C/T cg18578876 chr12:123200353 GPR109B -1.32 -15.95 -0.53 1.95e-48 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; BRCA cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg08885076 chr2:99613938 TSGA10 -0.35 -8.06 -0.3 3.82e-15 Chronic sinus infection; BRCA cis rs9469578 1.000 rs6942022 chr6:33710284 C/T cg18708504 chr6:33715942 IP6K3 0.71 10.41 0.38 1.5e-23 Phosphorus levels; BRCA trans rs61931739 0.517 rs12816423 chr12:34067736 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.12 0.49 1.32e-39 Morning vs. evening chronotype; BRCA cis rs2576037 0.796 rs2576038 chr18:44582200 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.22 0.31 1.16e-15 Personality dimensions; BRCA trans rs2204008 0.902 rs11520218 chr12:38223227 G/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs7582180 0.629 rs4850926 chr2:100954117 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.82 -0.3 2.17e-14 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.09 -0.3 2.98e-15 Bipolar disorder; BRCA cis rs9309473 0.687 rs6706235 chr2:73613558 C/G cg20560298 chr2:73613845 ALMS1 -0.52 -14.23 -0.49 4.24e-40 Metabolite levels; BRCA cis rs796364 1.000 rs281794 chr2:200846666 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 12.05 0.43 2.89e-30 Schizophrenia; BRCA trans rs6479891 1.000 rs59035163 chr10:65292043 C/G cg14819942 chr15:35414228 NA 0.35 8.41 0.32 2.7e-16 Arthritis (juvenile idiopathic); BRCA trans rs1005277 0.579 rs2474575 chr10:38387901 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.18 -0.31 1.59e-15 Colorectal cancer; BRCA cis rs17711722 0.727 rs1880555 chr7:65432567 T/C cg11764359 chr7:65958608 NA 0.62 13.65 0.48 2.09e-37 Calcium levels; BRCA cis rs10924970 0.934 rs4288584 chr1:235436631 C/T cg26050004 chr1:235667680 B3GALNT2 0.35 8.78 0.33 1.47e-17 Asthma; BRCA cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.12 0.43 1.47e-30 Mean platelet volume; BRCA trans rs3733585 0.624 rs58130873 chr4:9972081 T/C cg26043149 chr18:55253948 FECH -0.36 -7.98 -0.3 6.76e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs672059 1.000 rs659307 chr1:183163078 G/A ch.1.3577855R chr1:183094577 LAMC1 0.37 8.49 0.32 1.43e-16 Hypertriglyceridemia; BRCA cis rs7772486 0.875 rs2748497 chr6:146319417 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.41 0.5 5.89e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs7246657 0.943 rs2126977 chr19:37995747 C/G cg23950597 chr19:37808831 NA 0.61 11.15 0.4 1.72e-26 Coronary artery calcification; BRCA cis rs34779708 0.897 rs4934529 chr10:35302376 T/A cg03585969 chr10:35415529 CREM 0.56 11.59 0.42 2.64e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg11766577 chr21:47581405 C21orf56 0.48 10.67 0.39 1.4e-24 Testicular germ cell tumor; BRCA cis rs6840258 1.000 rs56050898 chr4:87945375 A/G cg08197287 chr4:87952173 AFF1 -0.44 -8.63 -0.32 4.89e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs6788895 1.000 rs76801042 chr3:150482720 A/C cg09723797 chr3:150481914 SIAH2 0.72 8.6 0.32 6.26e-17 Breast cancer; BRCA cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.44 9.78 0.36 3.86e-21 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7408868 0.563 rs10423702 chr19:15300069 T/C cg14696996 chr19:15285081 NOTCH3 0.8 11.92 0.43 1.06e-29 Pulse pressure; BRCA cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg08917208 chr2:24149416 ATAD2B 0.55 8.62 0.32 5.36e-17 Lymphocyte counts; BRCA cis rs7512552 0.780 rs1260411 chr1:150382088 G/A cg15654264 chr1:150340011 RPRD2 0.41 8.83 0.33 9.72e-18 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg00814883 chr7:100076585 TSC22D4 -0.5 -10.36 -0.38 2.32e-23 Platelet count; BRCA cis rs2011503 0.882 rs113841472 chr19:19565482 T/G cg15839431 chr19:19639596 YJEFN3 -0.41 -9.15 -0.34 7.81e-19 Bipolar disorder; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg23978390 chr7:1156363 C7orf50 0.41 10.04 0.37 4.07e-22 Longevity;Endometriosis; BRCA cis rs6700896 0.897 rs28480230 chr1:66124075 C/T cg04111102 chr1:66153794 NA 0.36 8.87 0.33 7.42e-18 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6484504 0.625 rs6484501 chr11:31373100 G/T cg26647111 chr11:31128758 NA 0.45 9.59 0.35 1.97e-20 Red blood cell count; BRCA cis rs709400 0.628 rs4906321 chr14:103878882 C/T cg26031613 chr14:104095156 KLC1 0.62 13.25 0.46 1.43e-35 Body mass index; BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg07308232 chr7:1071921 C7orf50 -0.5 -10.52 -0.38 5.4e-24 Longevity;Endometriosis; BRCA cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.86 0.36 1.96e-21 Bipolar disorder; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg15112475 chr7:1198522 ZFAND2A -0.58 -14.59 -0.5 8.19e-42 Longevity;Endometriosis; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs6063312 1.000 rs6063312 chr20:47343059 G/T cg18078177 chr20:47281410 PREX1 0.65 11.26 0.41 5.84e-27 Tonometry; BRCA cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg22875332 chr1:76189707 ACADM 0.79 18.87 0.6 1.86e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7833986 0.501 rs2976018 chr8:57014752 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.99 0.46 2.13e-34 Height; BRCA cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24308560 chr3:49941425 MST1R -0.38 -8.21 -0.31 1.24e-15 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.965 rs6805386 chr3:38557921 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.7 -19.27 -0.61 1.32e-65 Electrocardiographic conduction measures; BRCA cis rs926392 0.896 rs1569538 chr20:37685216 A/G cg16355469 chr20:37678765 NA -0.33 -8.33 -0.31 4.93e-16 Dialysis-related mortality; BRCA cis rs12142240 0.667 rs41293287 chr1:46808852 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.13 0.31 2.27e-15 Menopause (age at onset); BRCA cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg25237894 chr2:233734115 C2orf82 0.4 11.48 0.41 7.19e-28 Coronary artery disease; BRCA trans rs6601327 0.571 rs7838571 chr8:9647796 A/G cg06636001 chr8:8085503 FLJ10661 0.37 7.88 0.3 1.37e-14 Multiple myeloma (hyperdiploidy); BRCA cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg00898013 chr13:113819073 PROZ -0.36 -8.96 -0.33 3.48e-18 Platelet distribution width; BRCA cis rs4363385 0.626 rs11205192 chr1:153062767 C/T cg07796016 chr1:152779584 LCE1C -0.37 -7.99 -0.3 6.5e-15 Inflammatory skin disease; BRCA cis rs2346177 0.519 rs4563285 chr2:46669944 C/G cg02822958 chr2:46747628 ATP6V1E2 0.51 10.09 0.37 2.7e-22 HDL cholesterol; BRCA cis rs56804039 1.000 rs11777086 chr8:8384479 G/T cg06636001 chr8:8085503 FLJ10661 -0.55 -9.03 -0.34 1.94e-18 Cervical cancer; BRCA cis rs1065656 0.589 rs391543 chr16:1915583 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.37 7.81 0.3 2.34e-14 Insulin-like growth factors; BRCA cis rs4363385 0.620 rs4388644 chr1:152983674 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.15 -0.34 7.26e-19 Inflammatory skin disease; BRCA trans rs7647973 0.626 rs35129566 chr3:49866584 T/G cg21665057 chr3:196295764 WDR53;FBXO45 0.39 7.99 0.3 6.26e-15 Menarche (age at onset); BRCA cis rs8180040 0.647 rs57756484 chr3:47239333 A/G cg16586182 chr3:47516702 SCAP 0.56 12.61 0.45 1.06e-32 Colorectal cancer; BRCA cis rs7618915 0.524 rs35249778 chr3:52661640 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.89 0.36 1.53e-21 Bipolar disorder; BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.09 0.3 2.91e-15 Tonsillectomy; BRCA cis rs6138458 0.620 rs2151462 chr20:24911823 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.36 -0.31 3.95e-16 Blood protein levels; BRCA cis rs9283706 0.594 rs7717020 chr5:66353322 A/C cg11590213 chr5:66331682 MAST4 0.41 7.94 0.3 9.42e-15 Coronary artery disease; BRCA cis rs17376456 0.825 rs10061377 chr5:93174513 T/C cg21475434 chr5:93447410 FAM172A 0.7 8.61 0.32 5.52e-17 Diabetic retinopathy; BRCA cis rs1403694 0.695 rs3806689 chr3:186435077 A/G cg12454167 chr3:186435060 KNG1 0.29 7.9 0.3 1.21e-14 Blood protein levels; BRCA cis rs897080 0.515 rs1067400 chr2:44677647 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.34 0.35 1.58e-19 Height; BRCA cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg11812906 chr14:75593930 NEK9 0.67 15.45 0.52 5.25e-46 Height; BRCA cis rs4563143 0.675 rs56293553 chr19:29270455 A/G cg04546413 chr19:29218101 NA 0.63 12.26 0.44 3.6e-31 Methadone dose in opioid dependence; BRCA cis rs10751667 1.000 rs10794357 chr11:973374 T/C ch.11.42038R chr11:967971 AP2A2 0.58 18.92 0.6 9.84e-64 Alzheimer's disease (late onset); BRCA cis rs9392556 0.829 rs617790 chr6:4115758 C/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.37 -8.07 -0.3 3.6e-15 Blood metabolite levels; BRCA trans rs9784649 0.882 rs2201296 chr5:24967119 G/A cg08600765 chr20:34638493 LOC647979 -0.51 -8.4 -0.32 2.79e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9880211 0.752 rs9838884 chr3:136455704 C/T cg21827317 chr3:136751795 NA -0.46 -7.89 -0.3 1.33e-14 Body mass index;Height; BRCA cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA cis rs4074536 0.574 rs9887914 chr1:116287975 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.68 -0.32 3.25e-17 QRS duration; BRCA cis rs7577696 0.524 rs12991444 chr2:32265125 G/T cg02381751 chr2:32503542 YIPF4 -0.41 -7.86 -0.3 1.64e-14 Inflammatory biomarkers; BRCA trans rs11098499 0.697 rs35280960 chr4:120257059 G/A cg25214090 chr10:38739885 LOC399744 0.47 10.62 0.39 2.28e-24 Corneal astigmatism; BRCA cis rs72772090 0.539 rs11746534 chr5:96124807 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7267979 0.866 rs6138609 chr20:25570985 T/A cg08601574 chr20:25228251 PYGB 0.36 8.43 0.32 2.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6977660 0.714 rs17141884 chr7:19790280 A/G cg07541023 chr7:19748670 TWISTNB -0.57 -9.66 -0.36 1.1e-20 Thyroid stimulating hormone; BRCA cis rs3008870 1.000 rs12041926 chr1:67434602 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.77 0.65 5.16e-79 Lymphocyte percentage of white cells; BRCA cis rs11676348 0.846 rs3890158 chr2:218990292 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.96 -0.3 7.64e-15 Ulcerative colitis; BRCA cis rs7772486 0.790 rs4896852 chr6:146284621 T/C cg23711669 chr6:146136114 FBXO30 -0.79 -17.95 -0.58 1.17e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs4664304 0.620 rs1397717 chr2:160720444 G/T cg01092293 chr2:160761427 LY75 0.36 8.51 0.32 1.24e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12586317 0.620 rs79832710 chr14:35547434 G/T cg05294307 chr14:35346193 BAZ1A -0.61 -10.39 -0.38 1.73e-23 Psoriasis; BRCA cis rs12291225 0.877 rs2303974 chr11:14264979 G/T cg19336497 chr11:14380999 RRAS2 -0.36 -8.33 -0.31 4.86e-16 Sense of smell; BRCA cis rs17604090 0.816 rs10248839 chr7:29697253 T/C cg19413766 chr7:29689036 LOC646762 -0.61 -8.22 -0.31 1.1e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs2153535 0.580 rs4960412 chr6:8438261 G/C cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1e-40 Motion sickness; BRCA cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg05234568 chr11:5960015 NA -0.51 -9.93 -0.37 1.04e-21 DNA methylation (variation); BRCA cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg11764359 chr7:65958608 NA 0.78 18.28 0.59 2.24e-60 Aortic root size; BRCA cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg17328964 chr8:145687451 CYHR1 0.45 9.95 0.37 8.64e-22 Age at first birth; BRCA cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.8 -0.39 4.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg15448220 chr1:150897856 SETDB1 0.35 7.86 0.3 1.6e-14 Melanoma; BRCA trans rs911555 0.755 rs2756132 chr14:103967820 C/G cg17675199 chr6:35436792 RPL10A -0.3 -8.05 -0.3 4.1e-15 Intelligence (multi-trait analysis); BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg03709012 chr19:19516395 GATAD2A 0.82 19.22 0.61 2.52e-65 Tonsillectomy; BRCA cis rs9512730 0.527 rs11619784 chr13:27999643 A/G cg08193333 chr13:27998609 GTF3A 0.51 9.91 0.36 1.27e-21 Schizophrenia; BRCA cis rs9682041 0.627 rs3772173 chr3:170078232 C/T cg11886554 chr3:170076028 SKIL 0.48 9.92 0.37 1.1e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs28830936 1.000 rs28754734 chr15:42093152 C/T cg17847044 chr15:42102381 MAPKBP1 -0.37 -10.09 -0.37 2.56e-22 Diastolic blood pressure; BRCA cis rs941408 1.000 rs1076447 chr19:2792128 C/G cg06609049 chr19:2785107 THOP1 0.59 12.09 0.43 1.82e-30 Total cholesterol levels; BRCA cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg09537434 chr19:41945824 ATP5SL -0.6 -10.96 -0.4 1e-25 Colorectal cancer; BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg22535103 chr8:58192502 C8orf71 -0.52 -8.91 -0.33 5.21e-18 Developmental language disorder (linguistic errors); BRCA cis rs10197940 0.578 rs6718653 chr2:152346118 C/A cg06191203 chr2:152266755 RIF1 -0.29 -8.45 -0.32 1.96e-16 Lung cancer; BRCA cis rs1580019 0.883 rs6945294 chr7:32472099 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.42 8.81 0.33 1.22e-17 Cognitive ability; BRCA cis rs2108225 0.837 rs6466186 chr7:107446966 G/C cg18560240 chr7:107437656 SLC26A3 -0.52 -11.13 -0.4 2.06e-26 Ulcerative colitis; BRCA cis rs13102973 0.640 rs34037497 chr4:135833698 C/G cg14419869 chr4:135874104 NA 0.46 9.18 0.34 5.74e-19 Subjective well-being; BRCA cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg08085267 chr17:45401833 C17orf57 -0.57 -11.91 -0.43 1.07e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7267979 1.000 rs2259926 chr20:25281733 T/C cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.63e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs372883 0.600 rs407712 chr21:30722531 G/A cg24692254 chr21:30365293 RNF160 -0.5 -10.94 -0.4 1.22e-25 Pancreatic cancer; BRCA cis rs2991971 0.810 rs998199 chr1:45912898 A/C cg24296786 chr1:45957014 TESK2 -0.56 -13.18 -0.46 2.7900000000000003e-35 High light scatter reticulocyte count; BRCA cis rs895636 0.752 rs4245800 chr2:45189866 G/A cg16198908 chr2:45192207 NA 0.47 8.84 0.33 9.37e-18 Metabolite levels;Fasting plasma glucose; BRCA trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg11707556 chr5:10655725 ANKRD33B 0.39 8.02 0.3 4.92e-15 Coronary artery disease; BRCA cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs11229555 0.598 rs7930623 chr11:58197641 A/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs61931739 0.534 rs11052959 chr12:33997095 T/C cg26384229 chr12:38710491 ALG10B 0.66 13.84 0.48 2.82e-38 Morning vs. evening chronotype; BRCA cis rs10463316 0.744 rs6579869 chr5:150763621 G/A cg03212797 chr5:150827313 SLC36A1 -0.43 -8.4 -0.32 2.96e-16 Metabolite levels (Pyroglutamine); BRCA cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg08493051 chr2:3487164 NA -0.4 -8.26 -0.31 8.35e-16 Neurofibrillary tangles; BRCA cis rs13102973 0.867 rs11722699 chr4:135907871 G/T cg14419869 chr4:135874104 NA 0.46 9.06 0.34 1.51e-18 Subjective well-being; BRCA cis rs6089829 0.925 rs11086152 chr20:61664656 T/C cg08564027 chr20:61660810 NA 0.85 22.96 0.67 1.67e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg14829155 chr15:31115871 NA -0.43 -10.05 -0.37 3.67e-22 Huntington's disease progression; BRCA cis rs7914558 1.000 rs10786740 chr10:104935593 G/C cg04362960 chr10:104952993 NT5C2 0.43 10.45 0.38 1.01e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.81 14.55 0.5 1.22e-41 Platelet count; BRCA cis rs96067 0.711 rs795047 chr1:36637708 C/T cg24686825 chr1:36642396 MAP7D1 0.44 9.69 0.36 8.06e-21 Corneal structure; BRCA cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg24060327 chr5:131705240 SLC22A5 0.65 12.88 0.45 6.76e-34 Breast cancer; BRCA cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.39 9.25 0.34 3.44e-19 Platelet count; BRCA cis rs66731853 0.769 rs477679 chr1:20894618 A/G cg04087271 chr1:20915334 CDA 0.46 9.12 0.34 9.89e-19 Mean corpuscular volume; BRCA cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg26384229 chr12:38710491 ALG10B -0.62 -15.01 -0.51 7.7e-44 Drug-induced liver injury (flucloxacillin); BRCA cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg18230493 chr5:56204884 C5orf35 -0.54 -10.57 -0.39 3.5e-24 Type 2 diabetes; BRCA cis rs4713118 0.516 rs7739216 chr6:28079946 G/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.26 -0.31 8.6e-16 Parkinson's disease; BRCA cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg20203395 chr5:56204925 C5orf35 -0.51 -10.61 -0.39 2.56e-24 Initial pursuit acceleration; BRCA cis rs1371867 0.846 rs1788204 chr8:101303936 C/T cg06636551 chr8:101224915 SPAG1 -0.38 -8.72 -0.33 2.39e-17 Atrioventricular conduction; BRCA cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg11764359 chr7:65958608 NA -0.67 -14.97 -0.51 1.15e-43 Aortic root size; BRCA cis rs4629180 1.000 rs6744495 chr2:102099956 T/C cg04415270 chr2:102091202 RFX8 -0.32 -7.91 -0.3 1.14e-14 Chronic rhinosinusitis with nasal polyps; BRCA cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg01689657 chr7:91764605 CYP51A1 0.22 8.07 0.3 3.5e-15 Breast cancer; BRCA cis rs796364 0.806 rs203766 chr2:200902672 T/C cg23649088 chr2:200775458 C2orf69 -0.55 -7.86 -0.3 1.68e-14 Schizophrenia; BRCA cis rs4319547 0.737 rs11058226 chr12:122938958 A/G cg23029597 chr12:123009494 RSRC2 -0.41 -8.28 -0.31 7.34e-16 Body mass index; BRCA cis rs60871478 0.947 rs62432255 chr7:804219 G/A cg27478167 chr7:817139 HEATR2 -0.4 -8.46 -0.32 1.83e-16 Cerebrospinal P-tau181p levels; BRCA cis rs16866061 0.515 rs13020268 chr2:225437923 C/T cg12698349 chr2:225449008 CUL3 0.85 29.73 0.76 1.26e-122 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg10819733 chr22:24237672 NA -0.32 -8.55 -0.32 9.33e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs148734725 1 rs148734725 chr3:49406708 G/A cg21659725 chr3:3221576 CRBN -0.45 -10.01 -0.37 5.41e-22 Educational attainment (college completion); BRCA cis rs71636778 0.543 rs36109400 chr1:27247822 G/A cg12203394 chr1:27248618 NUDC 0.61 9.5 0.35 4.25e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs9487051 0.872 rs9386793 chr6:109610002 C/A cg12927641 chr6:109611667 NA -0.41 -10.71 -0.39 9.97e-25 Reticulocyte fraction of red cells; BRCA cis rs2842992 0.789 rs4709370 chr6:160210061 A/G cg11366901 chr6:160182831 ACAT2 0.82 16.07 0.54 4.79e-49 Age-related macular degeneration (geographic atrophy); BRCA cis rs11252926 0.574 rs7068976 chr10:453112 A/G cg16386425 chr10:429943 DIP2C -0.41 -8.59 -0.32 6.73e-17 Psychosis in Alzheimer's disease; BRCA cis rs9389248 0.690 rs728030 chr6:135246294 G/T cg22676075 chr6:135203613 NA -0.45 -9.41 -0.35 8.72e-20 High light scatter reticulocyte percentage of red cells; BRCA cis rs2204008 0.805 rs2874289 chr12:38258420 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.29 0.56 3.16e-55 Bladder cancer; BRCA cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.09 0.3 3.03e-15 Cognitive ability; BRCA trans rs9393777 0.920 rs41269265 chr6:27425349 T/C cg01620082 chr3:125678407 NA -0.75 -9.53 -0.35 3.14e-20 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg17372223 chr3:52568218 NT5DC2 0.34 7.86 0.3 1.68e-14 Electroencephalogram traits; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg25703541 chr22:24373054 LOC391322 -0.67 -15.37 -0.52 1.38e-45 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg06115741 chr20:33292138 TP53INP2 0.49 10.96 0.4 9.75e-26 Coronary artery disease; BRCA cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.35 8.65 0.32 4.16e-17 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs2637266 0.967 rs12244619 chr10:78352502 C/T cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.29e-14 Pulmonary function; BRCA cis rs9814567 0.806 rs9857995 chr3:134316706 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.36 8.42 0.32 2.57e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11758351 1.000 rs2143346 chr6:26198449 C/G cg01420254 chr6:26195488 NA -0.59 -9.21 -0.34 4.74e-19 Gout;Renal underexcretion gout; BRCA cis rs6942756 1.000 rs12111832 chr7:128889025 G/C cg02491457 chr7:128862824 NA -0.71 -14.02 -0.49 3.8e-39 White matter hyperintensity burden; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.89 0.62 6.82e-69 Platelet count; BRCA cis rs28669119 0.778 rs244752 chr5:88144669 T/C cg18498987 chr5:88179539 MEF2C 0.45 8.27 0.31 7.96e-16 Schizophrenia; BRCA cis rs6546550 0.901 rs1979214 chr2:70137498 G/C cg02498382 chr2:70120550 SNRNP27 -0.52 -11.47 -0.41 7.91e-28 Prevalent atrial fibrillation; BRCA cis rs208520 0.690 rs12213581 chr6:66735818 T/C cg07460842 chr6:66804631 NA 0.99 19.84 0.62 1.25e-68 Exhaled nitric oxide output; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs13190036 1.000 rs71601344 chr5:176633493 G/A cg06733329 chr5:176740039 MXD3 0.46 8.3 0.31 6.26e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs9649213 0.574 rs7789440 chr7:97888798 G/T cg21770322 chr7:97807741 LMTK2 0.44 11.22 0.41 8.32e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs12517041 0.935 rs2099089 chr5:23287372 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs6543140 0.964 rs2141781 chr2:103082906 G/A cg04239558 chr2:103089729 SLC9A4 0.35 9.94 0.37 9.48e-22 Blood protein levels; BRCA cis rs9443645 0.869 rs9361489 chr6:79816785 T/C cg18132916 chr6:79620363 NA -0.48 -10.69 -0.39 1.23e-24 Intelligence (multi-trait analysis); BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13126279 chr21:47581558 C21orf56 -0.48 -10.81 -0.39 3.91e-25 Testicular germ cell tumor; BRCA cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg04546413 chr19:29218101 NA 0.65 13.29 0.47 9.56e-36 Methadone dose in opioid dependence; BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.21 -0.34 4.54e-19 Total body bone mineral density; BRCA cis rs11716531 0.574 rs62256311 chr3:27271505 G/A cg02860705 chr3:27208620 NA 0.6 11.5 0.41 6.14e-28 Diastolic blood pressure; BRCA trans rs6952808 0.723 rs4721295 chr7:2036669 G/T cg04565464 chr8:145669602 NFKBIL2 -0.36 -8.54 -0.32 9.97e-17 Bipolar disorder and schizophrenia; BRCA cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg16405210 chr4:1374714 KIAA1530 -0.46 -10.48 -0.38 8.05e-24 Longevity; BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg01305625 chr5:131593812 PDLIM4 0.34 8.07 0.3 3.4e-15 Acylcarnitine levels; BRCA cis rs3125734 0.671 rs3852406 chr10:64015162 T/C cg09941381 chr10:64027924 RTKN2 -0.27 -7.9 -0.3 1.23e-14 Rheumatoid arthritis; BRCA cis rs7552167 0.852 rs10794647 chr1:24509133 C/T cg01960748 chr1:24522592 NA -0.62 -10.04 -0.37 4.04e-22 Psoriasis vulgaris; BRCA cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg10802521 chr3:52805072 NEK4 0.33 9.26 0.34 3.07e-19 Electroencephalogram traits; BRCA cis rs6860806 0.507 rs272892 chr5:131664349 C/T cg12564285 chr5:131593104 PDLIM4 0.34 7.9 0.3 1.22e-14 Breast cancer; BRCA cis rs6882046 0.513 rs651666 chr5:88048767 A/G cg22951263 chr5:87985283 NA -0.39 -10.83 -0.39 3.43e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs11677370 0.574 rs10209122 chr2:3871186 C/A cg17052675 chr2:3827356 NA -0.51 -12.16 -0.43 9.2e-31 Type 2 diabetes; BRCA cis rs2737618 0.651 rs2248967 chr1:200084893 A/G cg21825944 chr1:200113062 NR5A2 0.38 9.04 0.34 1.86e-18 Uric acid levels; BRCA cis rs12134245 0.776 rs6688261 chr1:91987034 C/T cg02896835 chr1:92012615 NA -0.62 -16.57 -0.55 1.53e-51 Breast cancer; BRCA cis rs4595586 0.525 rs12825567 chr12:39386621 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.25 0.34 3.33e-19 Morning vs. evening chronotype; BRCA cis rs965469 1.000 rs77763497 chr20:3250007 A/G cg25506879 chr20:3388711 C20orf194 -0.55 -10.79 -0.39 4.75e-25 IFN-related cytopenia; BRCA cis rs9291683 0.595 rs10939665 chr4:10037628 T/C cg11266682 chr4:10021025 SLC2A9 0.49 12.82 0.45 1.23e-33 Bone mineral density; BRCA cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg03477792 chr4:77819574 ANKRD56 0.66 15.67 0.53 4.35e-47 Emphysema distribution in smoking; BRCA cis rs12545109 0.800 rs2670053 chr8:57421998 A/T cg09654669 chr8:57350985 NA -0.4 -8.67 -0.32 3.62e-17 Obesity-related traits; BRCA cis rs11249608 0.511 rs58827878 chr5:178481936 C/G cg21905437 chr5:178450457 ZNF879 0.5 9.61 0.36 1.66e-20 Pubertal anthropometrics; BRCA cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg17845761 chr1:175162550 KIAA0040 0.26 9.65 0.36 1.11e-20 Alcohol dependence; BRCA cis rs992157 0.835 rs2292555 chr2:219146882 G/C cg00012203 chr2:219082015 ARPC2 -0.5 -9.65 -0.36 1.2e-20 Colorectal cancer; BRCA cis rs6435862 0.636 rs717548 chr2:215676905 G/A cg04004882 chr2:215674386 BARD1 -0.74 -17.74 -0.57 1.57e-57 Neuroblastoma (high-risk); BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs2742234 0.541 rs1254958 chr10:43702143 C/T cg15436174 chr10:43711423 RASGEF1A 0.57 11.53 0.41 4.62e-28 Hirschsprung disease; BRCA cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg14847009 chr1:175162515 KIAA0040 -0.24 -9.08 -0.34 1.29e-18 Alcohol dependence; BRCA cis rs7178424 1.000 rs8025877 chr15:62377820 A/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.26 -0.31 8.22e-16 Height; BRCA cis rs35146811 0.731 rs2257213 chr7:99810113 T/C cg13334819 chr7:99746414 C7orf59 0.4 9.17 0.34 6.33e-19 Coronary artery disease; BRCA cis rs1065852 0.526 rs9623489 chr22:42397026 A/G cg22189786 chr22:42395067 WBP2NL 0.43 8.74 0.33 1.97e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs7267979 1.000 rs2258719 chr20:25275843 C/T cg08601574 chr20:25228251 PYGB 0.39 8.98 0.33 2.96e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg13902645 chr11:5959945 NA -0.56 -11.36 -0.41 2.36e-27 DNA methylation (variation); BRCA cis rs897984 0.511 rs7196726 chr16:31092075 G/A cg02466173 chr16:30829666 NA -0.43 -9.61 -0.36 1.58e-20 Dementia with Lewy bodies; BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg23708337 chr7:1209742 NA 0.64 8.95 0.33 3.76e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7301016 0.846 rs11174568 chr12:63021157 T/C cg11441379 chr12:63026424 NA 0.49 8.95 0.33 3.85e-18 IgG glycosylation; BRCA cis rs7264396 0.561 rs6142470 chr20:34570579 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -9.77 -0.36 4.3e-21 Total cholesterol levels; BRCA cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg03264133 chr6:25882463 NA -0.47 -10.33 -0.38 3.16e-23 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.739 rs10031033 chr4:120151452 C/T cg09307838 chr4:120376055 NA 0.46 8.8 0.33 1.29e-17 Corneal astigmatism; BRCA cis rs11608355 0.545 rs12819142 chr12:109896316 G/T cg05360138 chr12:110035743 NA 0.65 10.77 0.39 5.72e-25 Neuroticism; BRCA cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg25237894 chr2:233734115 C2orf82 -0.36 -10.49 -0.38 7.07e-24 Coronary artery disease; BRCA trans rs61931739 0.500 rs3924705 chr12:34557825 A/T cg26384229 chr12:38710491 ALG10B 0.59 13.62 0.47 2.98e-37 Morning vs. evening chronotype; BRCA cis rs7523273 0.606 rs859705 chr1:207959665 A/G cg22525895 chr1:207977042 MIR29B2 0.5 12.72 0.45 3.46e-33 Schizophrenia; BRCA cis rs6942756 1.000 rs13235749 chr7:128879678 C/G cg02491457 chr7:128862824 NA -0.73 -14.9 -0.51 2.65e-43 White matter hyperintensity burden; BRCA cis rs169738 1 rs169738 chr6:33537546 A/G cg24505687 chr6:33548425 BAK1 0.38 8.4 0.32 2.84e-16 Platelet count;Autism spectrum disorder or schizophrenia; BRCA cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg11764359 chr7:65958608 NA -0.73 -16.06 -0.54 5.07e-49 Aortic root size; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg24101359 chr6:42928495 GNMT -0.54 -12.79 -0.45 1.67e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6545883 0.965 rs778752 chr2:61776902 C/G cg15711740 chr2:61764176 XPO1 -0.57 -14.71 -0.5 2.12e-42 Tuberculosis; BRCA cis rs4975616 0.843 rs4975615 chr5:1315343 C/T cg26373071 chr5:1325741 CLPTM1L -0.43 -10.06 -0.37 3.35e-22 Lung cancer; BRCA cis rs2015599 0.549 rs7972032 chr12:29444284 G/A cg09582351 chr12:29534625 ERGIC2 -0.35 -8.23 -0.31 1.05e-15 Mean platelet volume;Platelet count; BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.22 0.34 4.38e-19 Tonsillectomy; BRCA cis rs7666738 0.606 rs13108868 chr4:99083753 C/T cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 6.87e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -10.0 -0.37 5.83e-22 Aortic root size; BRCA trans rs3780486 1.000 rs10813951 chr9:33128021 C/T cg04842962 chr6:43655489 MRPS18A -0.98 -22.41 -0.66 1.7e-82 IgG glycosylation; BRCA trans rs11039798 1.000 rs10769370 chr11:48515430 A/G cg15704280 chr7:45808275 SEPT13 0.57 8.5 0.32 1.35e-16 Axial length; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00149659 chr3:10157352 C3orf10 0.71 12.54 0.44 2.2e-32 Alzheimer's disease; BRCA cis rs7927592 0.871 rs12941 chr11:68382193 C/T cg20283391 chr11:68216788 NA -0.46 -9.22 -0.34 4.1e-19 Total body bone mineral density; BRCA cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg15212455 chr7:39170539 POU6F2 0.44 9.68 0.36 8.81e-21 IgG glycosylation; BRCA cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg19628046 chr18:33552617 C18orf21 -0.63 -13.06 -0.46 9.73e-35 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs75804782 0.641 rs56396448 chr2:239335234 C/T cg01134436 chr17:81009848 B3GNTL1 0.74 9.46 0.35 5.65e-20 Morning vs. evening chronotype;Chronotype; BRCA cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.38 -8.79 -0.33 1.41e-17 Alzheimer's disease (late onset); BRCA cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.78 21.3 0.64 1.84e-76 Multiple sclerosis; BRCA cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.47 -0.32 1.67e-16 Monocyte percentage of white cells; BRCA cis rs11734570 0.581 rs55958238 chr4:38604331 A/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.52 9.57 0.35 2.24e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg04709771 chr16:646395 RAB40C 0.45 11.24 0.41 7.44e-27 Height; BRCA cis rs17401966 1.000 rs7520935 chr1:10354271 G/T cg03954927 chr1:10346856 KIF1B 0.45 12.96 0.46 2.73e-34 Hepatocellular carcinoma; BRCA cis rs7927771 1.000 rs12363232 chr11:47623890 C/T cg18512352 chr11:47633146 NA -0.38 -9.26 -0.34 3.03e-19 Subjective well-being; BRCA cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.83 0.42 2.47e-29 Hip circumference adjusted for BMI; BRCA cis rs7267979 0.966 rs2261720 chr20:25260641 T/G cg08601574 chr20:25228251 PYGB 0.36 8.72 0.33 2.4e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.2 0.31 1.28e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6138458 1.000 rs227621 chr20:24910528 A/C cg26195577 chr20:24973756 C20orf3 0.98 24.76 0.7 2.17e-95 Blood protein levels; BRCA cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg06784218 chr1:46089804 CCDC17 -0.45 -10.8 -0.39 4.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg20203395 chr5:56204925 C5orf35 0.38 8.62 0.32 5.15e-17 Initial pursuit acceleration; BRCA cis rs9649213 0.593 rs1468338 chr7:97951118 T/C cg21770322 chr7:97807741 LMTK2 0.41 10.97 0.4 8.81e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs2425143 1.000 rs11699690 chr20:34271774 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.0 -0.34 2.46e-18 Blood protein levels; BRCA cis rs1865721 1.000 rs8091890 chr18:73197242 T/C cg26385618 chr18:73139727 C18orf62 -0.39 -8.73 -0.33 2.27e-17 Intelligence; BRCA cis rs7512552 0.839 rs834236 chr1:150362968 C/T cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.96e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7727544 0.716 rs4705926 chr5:131561758 C/T cg14196790 chr5:131705035 SLC22A5 0.4 10.15 0.37 1.51e-22 Blood metabolite levels; BRCA cis rs6963495 0.818 rs116457537 chr7:105152072 A/G cg19920283 chr7:105172520 RINT1 0.58 9.35 0.35 1.42e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6964587 0.626 rs2188841 chr7:91522641 A/G cg17063962 chr7:91808500 NA -0.55 -12.64 -0.45 7.58e-33 Breast cancer; BRCA cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg20307385 chr11:47447363 PSMC3 -0.42 -8.67 -0.32 3.47e-17 Subjective well-being; BRCA cis rs11874712 1.000 rs9945606 chr18:43673325 A/G cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.09 0.3 2.98e-15 Migraine - clinic-based; BRCA cis rs9733 0.596 rs11204704 chr1:150671630 T/C cg17724175 chr1:150552817 MCL1 0.25 8.21 0.31 1.26e-15 Tonsillectomy; BRCA cis rs10751667 0.600 rs10751665 chr11:941300 G/A cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.42e-34 Alzheimer's disease (late onset); BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg26608667 chr7:1196370 ZFAND2A 0.44 10.31 0.38 3.79e-23 Longevity;Endometriosis; BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07256732 chr16:621771 PIGQ -0.34 -9.05 -0.34 1.73e-18 Height; BRCA cis rs926392 0.640 rs62202616 chr20:37692775 G/C cg16355469 chr20:37678765 NA 0.52 11.46 0.41 8.49e-28 Dialysis-related mortality; BRCA cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg02734326 chr4:10020555 SLC2A9 0.39 8.51 0.32 1.21e-16 Bone mineral density; BRCA cis rs10504073 0.626 rs9298106 chr8:50007508 T/G cg00325661 chr8:49890786 NA 0.38 11.2 0.4 1.07e-26 Blood metabolite ratios; BRCA cis rs7551345 0.592 rs12087046 chr1:31700412 C/T cg19084893 chr1:31688959 NA 0.42 9.22 0.34 4.31e-19 Schizophrenia; BRCA cis rs2730245 0.959 rs2527201 chr7:158738611 G/T cg24397884 chr7:158709396 WDR60 -0.99 -25.51 -0.71 1.62e-99 Height; BRCA cis rs4803468 1.000 rs2304242 chr19:41944616 G/T cg09537434 chr19:41945824 ATP5SL 1.01 23.79 0.69 4.72e-90 Height; BRCA cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg24296786 chr1:45957014 TESK2 -0.63 -15.1 -0.51 2.8e-44 High light scatter reticulocyte count; BRCA cis rs6460942 0.841 rs62448597 chr7:12449110 G/C cg06484146 chr7:12443880 VWDE -0.72 -10.73 -0.39 8.24e-25 Coronary artery disease; BRCA trans rs11098499 0.954 rs71614438 chr4:120371252 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg23711669 chr6:146136114 FBXO30 -0.71 -16.8 -0.55 9.37e-53 Lobe attachment (rater-scored or self-reported); BRCA trans rs6076960 0.684 rs3852947 chr20:6255341 A/G cg21095983 chr6:86352623 SYNCRIP 0.4 8.92 0.33 4.82e-18 Smooth-surface caries; BRCA cis rs4077515 0.967 rs10781500 chr9:139269338 A/G cg14019695 chr9:139328340 INPP5E -0.31 -8.05 -0.3 4.16e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs953387 1.000 rs4954569 chr2:136913375 C/T cg05194412 chr2:137003533 NA -0.38 -8.63 -0.32 4.7e-17 Arthritis (juvenile idiopathic); BRCA cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg06115741 chr20:33292138 TP53INP2 -0.45 -10.04 -0.37 4.13e-22 Coronary artery disease; BRCA cis rs1003719 0.788 rs2835597 chr21:38466539 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA trans rs7830939 0.553 rs10105543 chr8:9323515 C/T cg15556689 chr8:8085844 FLJ10661 0.33 7.93 0.3 1.01e-14 Neuroticism; BRCA cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg10523679 chr1:76189770 ACADM 0.88 20.7 0.63 2.98e-73 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg20476274 chr7:133979776 SLC35B4 0.45 11.72 0.42 7.14e-29 Mean platelet volume; BRCA cis rs4074536 0.622 rs10923445 chr1:116320833 T/C cg21648376 chr1:116311395 CASQ2 -0.54 -9.03 -0.34 1.99e-18 QRS duration; BRCA cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg14829155 chr15:31115871 NA -0.43 -10.01 -0.37 5.19e-22 Huntington's disease progression; BRCA cis rs1568889 0.838 rs7952717 chr11:28261658 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.57 0.63 1.47e-72 Bipolar disorder; BRCA cis rs2070488 0.775 rs13072731 chr3:38533335 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.07 0.56 4.16e-54 Electrocardiographic conduction measures; BRCA cis rs9287719 0.810 rs1990612 chr2:10781944 A/G cg00105475 chr2:10696890 NA 0.42 9.63 0.36 1.44e-20 Prostate cancer; BRCA cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg11764359 chr7:65958608 NA -0.67 -15.11 -0.51 2.51e-44 Aortic root size; BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg05793240 chr7:2802953 GNA12 -0.31 -7.95 -0.3 8.63e-15 Height; BRCA cis rs7520050 0.966 rs4545281 chr1:46360054 C/T cg24296786 chr1:45957014 TESK2 0.41 9.3 0.35 2.13e-19 Red blood cell count;Reticulocyte count; BRCA cis rs2404602 0.552 rs4886823 chr15:76965402 A/G cg23625390 chr15:77176239 SCAPER -0.52 -12.2 -0.43 6.41e-31 Blood metabolite levels; BRCA cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg14349672 chr11:133703707 NA -0.42 -9.28 -0.34 2.58e-19 Childhood ear infection; BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg21782813 chr7:2030301 MAD1L1 0.42 12.04 0.43 3.14e-30 Autism spectrum disorder or schizophrenia; BRCA cis rs365132 0.517 rs3762974 chr5:176328336 G/A cg16309518 chr5:176445507 NA 0.45 10.57 0.39 3.57e-24 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs12618769 0.597 rs72819987 chr2:99046253 A/G cg10123293 chr2:99228465 UNC50 0.41 8.3 0.31 6.37e-16 Bipolar disorder; BRCA cis rs7617773 0.746 rs4371540 chr3:48353543 G/A cg11946769 chr3:48343235 NME6 0.69 13.8 0.48 4.23e-38 Coronary artery disease; BRCA cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg18225595 chr11:63971243 STIP1 0.53 9.61 0.36 1.61e-20 Mean platelet volume; BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg21782813 chr7:2030301 MAD1L1 0.38 9.9 0.36 1.37e-21 Bipolar disorder and schizophrenia; BRCA cis rs11105298 0.891 rs10858869 chr12:89857611 C/T cg00757033 chr12:89920650 WDR51B 0.52 10.45 0.38 1.03e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg03213289 chr20:61660250 NA 0.62 16.39 0.54 1.23e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs6005807 0.719 rs16986398 chr22:28815629 A/C cg12565055 chr22:29076175 TTC28 0.43 8.31 0.31 5.83e-16 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs9443645 0.527 rs7756996 chr6:79509367 A/C cg05283184 chr6:79620031 NA -0.36 -8.18 -0.31 1.54e-15 Intelligence (multi-trait analysis); BRCA cis rs9858542 0.953 rs7646366 chr3:49470668 G/A cg03060546 chr3:49711283 APEH -0.53 -10.6 -0.39 2.62e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.45 0.66 9.73e-83 Platelet count; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg02353165 chr6:42928485 GNMT 0.76 18.46 0.59 2.62e-61 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11997175 0.583 rs66622174 chr8:33812542 T/G ch.8.33884649F chr8:33765107 NA 0.36 8.28 0.31 6.99e-16 Body mass index; BRCA trans rs17685 0.712 rs6464994 chr7:75784668 C/T cg19862616 chr7:65841803 NCRNA00174 0.82 26.58 0.72 2.01e-105 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4302748 0.862 rs73337008 chr7:36187715 G/T cg24442661 chr7:36192818 EEPD1 0.47 8.78 0.33 1.48e-17 Platelet count; BRCA cis rs8062405 1.000 rs7498665 chr16:28883241 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4727027 0.704 rs12704073 chr7:148905067 G/A cg23583168 chr7:148888333 NA -0.96 -25.45 -0.71 3.49e-99 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7766436 0.614 rs55663812 chr6:22562881 G/A cg13666174 chr6:22585274 NA -0.41 -8.63 -0.32 4.72e-17 Coronary artery disease; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg25036284 chr2:26402008 FAM59B -0.63 -10.48 -0.38 8.25e-24 Gut microbiome composition (summer); BRCA cis rs10504073 0.647 rs11785310 chr8:50025035 G/A cg00325661 chr8:49890786 NA 0.44 12.58 0.45 1.4e-32 Blood metabolite ratios; BRCA cis rs2731664 0.792 rs465670 chr5:176877624 C/T cg23176889 chr5:176863531 GRK6 -0.62 -16.79 -0.55 1.1e-52 Intelligence (multi-trait analysis); BRCA trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg17470723 chr8:74884337 TCEB1 0.41 8.64 0.32 4.43e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg13010199 chr12:38710504 ALG10B 0.45 9.25 0.34 3.44e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg02187348 chr16:89574699 SPG7 0.35 8.22 0.31 1.13e-15 Multiple myeloma (IgH translocation); BRCA cis rs832540 0.931 rs33319 chr5:56206675 C/A cg24531977 chr5:56204891 C5orf35 -0.41 -8.41 -0.32 2.73e-16 Coronary artery disease; BRCA cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg21995147 chr19:1064017 ABCA7 -0.38 -8.19 -0.31 1.41e-15 Alzheimer's disease (late onset); BRCA cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg06784218 chr1:46089804 CCDC17 0.46 10.93 0.4 1.34e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs6582630 0.519 rs12368889 chr12:38315160 G/A cg06521331 chr12:34319734 NA -0.53 -9.48 -0.35 4.76e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.54 -8.52 -0.32 1.1e-16 Schizophrenia; BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg16606324 chr3:10149918 C3orf24 0.58 11.66 0.42 1.3e-28 Alzheimer's disease; BRCA cis rs250677 0.687 rs3095947 chr5:148436728 T/C cg23229984 chr5:148520753 ABLIM3 0.35 8.86 0.33 7.66e-18 Breast cancer; BRCA cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg17366294 chr4:99064904 C4orf37 -0.45 -10.55 -0.39 4.21e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg11952622 chr19:58962976 ZNF324B 0.41 8.22 0.31 1.13e-15 Uric acid clearance; BRCA cis rs7714584 1.000 rs11741861 chr5:150277909 C/T cg22134413 chr5:150180641 NA -0.84 -11.35 -0.41 2.6e-27 Crohn's disease; BRCA trans rs6479891 1.000 rs4746138 chr10:65241741 A/G cg14819942 chr15:35414228 NA 0.34 8.56 0.32 8.39e-17 Arthritis (juvenile idiopathic); BRCA trans rs6951245 0.554 rs58210047 chr7:1149381 G/A cg13565492 chr6:43139072 SRF -0.88 -15.78 -0.53 1.31e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs738322 0.934 rs84473 chr22:38557326 T/C cg25457927 chr22:38595422 NA -0.32 -12.03 -0.43 3.61e-30 Cutaneous nevi; BRCA cis rs875971 1.000 rs937495 chr7:65779798 A/G cg18876405 chr7:65276391 NA -0.55 -13.02 -0.46 1.6e-34 Aortic root size; BRCA cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg12564285 chr5:131593104 PDLIM4 -0.35 -7.9 -0.3 1.18e-14 Breast cancer; BRCA cis rs4363385 0.720 rs11205150 chr1:152959266 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.75 -0.36 5.12e-21 Inflammatory skin disease; BRCA cis rs13102973 0.640 rs11722290 chr4:135832268 C/T cg14419869 chr4:135874104 NA 0.46 9.33 0.35 1.67e-19 Subjective well-being; BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.79 -0.42 3.69e-29 Gut microbiome composition (summer); BRCA cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg18357526 chr6:26021779 HIST1H4A 0.49 8.67 0.32 3.59e-17 Intelligence (multi-trait analysis); BRCA cis rs11059919 1 rs11059919 chr12:129289190 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.16 0.34 6.71e-19 Systemic lupus erythematosus; BRCA cis rs882300 0.967 rs12691876 chr2:136963794 A/G cg05194412 chr2:137003533 NA -0.38 -8.17 -0.31 1.67e-15 Multiple sclerosis;Electrocardiographic traits; BRCA cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg17143192 chr8:8559678 CLDN23 -0.61 -12.65 -0.45 7.03e-33 Obesity-related traits; BRCA cis rs2243480 1.000 rs4718309 chr7:65627764 G/C cg18252515 chr7:66147081 NA 1.03 15.25 0.52 5.04e-45 Diabetic kidney disease; BRCA trans rs61931739 0.529 rs1525900 chr12:33976652 T/G cg26384229 chr12:38710491 ALG10B 0.4 9.05 0.34 1.69e-18 Morning vs. evening chronotype; BRCA cis rs17253792 0.822 rs75763956 chr14:56071176 A/G cg01858014 chr14:56050164 KTN1 -0.78 -11.08 -0.4 3.31e-26 Putamen volume; BRCA cis rs877282 0.947 rs7904978 chr10:768078 C/T cg17470449 chr10:769945 NA 0.49 8.47 0.32 1.72e-16 Uric acid levels; BRCA cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg20302533 chr7:39170763 POU6F2 0.38 8.05 0.3 4.18e-15 IgG glycosylation; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg08132940 chr7:1081526 C7orf50 -0.48 -7.95 -0.3 8.72e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg25478527 chr11:95522999 CEP57;FAM76B -0.4 -8.29 -0.31 6.49e-16 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs870825 0.616 rs61653735 chr4:185630025 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.28 0.56 3.69e-55 Blood protein levels; BRCA cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg07741184 chr6:167504864 NA 0.29 8.36 0.31 3.96e-16 Crohn's disease; BRCA cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg13660082 chr14:53194042 PSMC6 -0.57 -8.76 -0.33 1.76e-17 Alzheimer's disease (late onset); BRCA cis rs7131987 0.650 rs10843377 chr12:29437053 C/G cg09582351 chr12:29534625 ERGIC2 0.46 10.71 0.39 9.54e-25 QT interval; BRCA cis rs826838 0.616 rs11182893 chr12:38627715 C/G cg26384229 chr12:38710491 ALG10B -0.44 -10.17 -0.37 1.28e-22 Heart rate; BRCA cis rs6831352 0.918 rs2851246 chr4:100046104 A/G cg13256891 chr4:100009986 ADH5 0.52 9.71 0.36 6.81e-21 Alcohol dependence; BRCA cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg11644478 chr21:40555479 PSMG1 -0.5 -10.7 -0.39 1.05e-24 Menarche (age at onset); BRCA cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg24642439 chr20:33292090 TP53INP2 0.55 12.18 0.43 7.98e-31 Coronary artery disease; BRCA cis rs1371614 0.611 rs3843322 chr2:27131849 G/T cg12368169 chr2:27073192 DPYSL5 0.28 8.35 0.31 4.32e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg04450456 chr4:17643702 FAM184B 0.37 10.88 0.4 2.04e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9790314 1.000 rs3849524 chr3:161015589 C/T cg03342759 chr3:160939853 NMD3 -0.62 -13.44 -0.47 1.89e-36 Morning vs. evening chronotype; BRCA cis rs9443645 0.869 rs9343863 chr6:79752792 T/C cg11833968 chr6:79620685 NA -0.46 -10.4 -0.38 1.72e-23 Intelligence (multi-trait analysis); BRCA cis rs9368481 0.743 rs9368480 chr6:26955750 A/C cg12292205 chr6:26970375 C6orf41 0.78 18.73 0.6 1.04e-62 Autism spectrum disorder or schizophrenia; BRCA cis rs7903847 0.642 rs2297667 chr10:99145492 A/T cg08345082 chr10:99160200 RRP12 -0.29 -8.49 -0.32 1.44e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg24642439 chr20:33292090 TP53INP2 -0.44 -8.46 -0.32 1.89e-16 Glomerular filtration rate (creatinine); BRCA cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.17 0.31 1.63e-15 Menopause (age at onset); BRCA cis rs2180341 0.700 rs4598100 chr6:127565314 G/A cg24812749 chr6:127587940 RNF146 0.72 14.79 0.51 8.42e-43 Breast cancer; BRCA cis rs2658782 0.694 rs3019221 chr11:93079700 C/G cg15737290 chr11:93063684 CCDC67 0.48 9.99 0.37 6.31e-22 Pulmonary function decline; BRCA cis rs4664304 0.739 rs2162500 chr2:160708645 C/G cg01092293 chr2:160761427 LY75 0.39 9.32 0.35 1.87e-19 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2836974 0.897 rs4817996 chr21:40525759 G/C cg11890956 chr21:40555474 PSMG1 1.06 31.69 0.78 3.73e-133 Cognitive function; BRCA cis rs2425143 1.000 rs11167275 chr20:34340275 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.08 -0.34 1.29e-18 Blood protein levels; BRCA cis rs6977660 0.714 rs4719586 chr7:19825548 T/C cg05791153 chr7:19748676 TWISTNB 0.58 10.92 0.4 1.41e-25 Thyroid stimulating hormone; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.26 0.34 3.1e-19 Tonsillectomy; BRCA cis rs34779708 0.966 rs11599606 chr10:35406626 G/A cg03585969 chr10:35415529 CREM 0.56 11.46 0.41 9.11e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12477438 0.501 rs11683188 chr2:99724512 T/C cg08885076 chr2:99613938 TSGA10 0.42 9.88 0.36 1.61e-21 Chronic sinus infection; BRCA cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg17971929 chr21:40555470 PSMG1 -0.49 -10.69 -0.39 1.23e-24 Menarche (age at onset); BRCA cis rs1113500 0.933 rs3909076 chr1:108631760 T/C cg06207961 chr1:108661230 NA 0.46 11.07 0.4 3.59e-26 Growth-regulated protein alpha levels; BRCA cis rs754466 0.957 rs61854183 chr10:79698077 T/C cg17075019 chr10:79541650 NA -0.65 -12.13 -0.43 1.22e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg21535247 chr6:8435926 SLC35B3 0.39 8.78 0.33 1.48e-17 Motion sickness; BRCA cis rs1371614 0.531 rs77562583 chr2:27151643 G/A cg00617064 chr2:27272375 NA -0.31 -8.14 -0.31 2.09e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs514406 0.929 rs562178 chr1:53319562 T/C cg01802117 chr1:53393560 SCP2 -0.35 -8.16 -0.31 1.78e-15 Monocyte count; BRCA cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg21573476 chr21:45109991 RRP1B -0.35 -9.08 -0.34 1.36e-18 Mean corpuscular volume; BRCA trans rs6582630 0.519 rs11495724 chr12:38337507 T/C cg06521331 chr12:34319734 NA -0.47 -8.52 -0.32 1.11e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg21395723 chr22:39101663 GTPBP1 -0.38 -8.08 -0.3 3.25e-15 Menopause (age at onset); BRCA cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.614 rs4729432 chr7:97947055 G/C cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.67 -0.53 4.36e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs9473147 0.747 rs9395288 chr6:47598125 C/T cg12968598 chr6:47444699 CD2AP 0.39 7.86 0.3 1.59e-14 Platelet distribution width;Mean platelet volume; BRCA cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg04756594 chr16:24857601 SLC5A11 0.35 8.29 0.31 6.49e-16 Intelligence (multi-trait analysis); BRCA cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.17 0.43 8.33e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7122539 0.839 rs6591223 chr11:66609289 C/T cg24851651 chr11:66362959 CCS 0.4 8.37 0.31 3.55e-16 HIV-1 susceptibility; BRCA trans rs35110281 0.693 rs2251253 chr21:45092257 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.46 0.32 1.88e-16 Mean corpuscular volume; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg05552183 chr6:42928497 GNMT 0.7 15.86 0.53 5.03e-48 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg04450456 chr4:17643702 FAM184B -0.34 -9.83 -0.36 2.58e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs858239 0.537 rs6955115 chr7:23227144 A/G cg23682824 chr7:23144976 KLHL7 0.35 8.86 0.33 7.81e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs926392 0.666 rs56877916 chr20:37696192 A/T cg16355469 chr20:37678765 NA 0.48 11.36 0.41 2.28e-27 Dialysis-related mortality; BRCA cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg26408565 chr15:76604113 ETFA -0.44 -9.56 -0.35 2.59e-20 Blood metabolite levels; BRCA cis rs875971 0.564 rs313804 chr7:65514622 A/G cg11764359 chr7:65958608 NA 0.75 17.49 0.57 2.93e-56 Aortic root size; BRCA cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.38 0.49 8.14e-41 Colorectal cancer; BRCA cis rs7646881 0.812 rs73017536 chr3:158460602 C/T cg19483011 chr3:158453295 NA -0.46 -8.05 -0.3 4.08e-15 Tetralogy of Fallot; BRCA trans rs61931739 0.817 rs1687002 chr12:34170263 T/C cg26384229 chr12:38710491 ALG10B 0.43 10.26 0.38 5.53e-23 Morning vs. evening chronotype; BRCA cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg01849466 chr14:104193079 ZFYVE21 0.43 10.95 0.4 1.12e-25 Schizophrenia; BRCA cis rs875971 0.545 rs801212 chr7:66015630 C/G cg11764359 chr7:65958608 NA -0.64 -11.45 -0.41 9.95e-28 Aortic root size; BRCA cis rs858239 0.932 rs1728313 chr7:23271031 A/C cg23682824 chr7:23144976 KLHL7 0.34 8.77 0.33 1.65e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg10523679 chr1:76189770 ACADM 0.72 15.04 0.51 5.56e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9291683 0.530 rs11723970 chr4:9980462 T/C cg02734326 chr4:10020555 SLC2A9 0.35 7.84 0.3 1.83e-14 Bone mineral density; BRCA cis rs79839061 0.610 rs2306252 chr4:892116 T/C cg07828340 chr4:882639 GAK 0.79 11.5 0.41 6.1e-28 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs4815420 chr20:25383979 C/T cg08601574 chr20:25228251 PYGB -0.33 -7.86 -0.3 1.58e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg06238570 chr21:40685208 BRWD1 -0.41 -8.3 -0.31 6.11e-16 Cognitive function; BRCA cis rs13256369 1.000 rs10088439 chr8:8576699 T/G cg06671706 chr8:8559999 CLDN23 0.43 8.43 0.32 2.38e-16 Obesity-related traits; BRCA cis rs11711311 1.000 rs4362695 chr3:113534856 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.35 -0.38 2.49e-23 IgG glycosylation; BRCA cis rs796364 1.000 rs281759 chr2:200787719 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.66 0.42 1.24e-28 Schizophrenia; BRCA cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg01877450 chr7:97915802 BRI3 -0.38 -8.82 -0.33 1.11e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7662987 0.540 rs2851257 chr4:100039499 G/C cg13256891 chr4:100009986 ADH5 0.54 9.97 0.37 7.58e-22 Smoking initiation; BRCA cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg09682330 chr6:28411287 ZSCAN23 -0.37 -7.82 -0.3 2.15e-14 Pubertal anthropometrics; BRCA cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg25208724 chr1:156163844 SLC25A44 1.07 35.59 0.82 9.17e-154 Testicular germ cell tumor; BRCA cis rs8180040 0.620 rs2278963 chr3:47054869 G/T cg27129171 chr3:47204927 SETD2 -0.74 -17.51 -0.57 2.34e-56 Colorectal cancer; BRCA cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg06552810 chr11:31128660 NA 0.4 8.66 0.32 3.75e-17 Red blood cell count; BRCA cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg06671706 chr8:8559999 CLDN23 0.41 8.11 0.31 2.67e-15 Obesity-related traits; BRCA cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg21699342 chr2:239360505 ASB1 0.5 11.52 0.41 5.08e-28 Multiple system atrophy; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg26314531 chr2:26401878 FAM59B 0.95 16.58 0.55 1.33e-51 Gut microbiome composition (summer); BRCA cis rs9814567 1.000 rs2177601 chr3:134245434 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 12.51 0.44 2.84e-32 Platelet count; BRCA cis rs6120849 0.754 rs17319032 chr20:33643296 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs4268898 0.552 rs35331966 chr2:24367828 C/T cg06627628 chr2:24431161 ITSN2 0.4 8.51 0.32 1.24e-16 Asthma; BRCA cis rs7178424 1.000 rs7178540 chr15:62380132 A/G cg00456672 chr15:62358751 C2CD4A 0.35 8.27 0.31 7.8e-16 Height; BRCA cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs847577 0.540 rs3847055 chr7:97680645 A/G cg18676790 chr7:97680731 NA -0.37 -8.25 -0.31 9.09e-16 Breast cancer; BRCA cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg08048268 chr3:133502702 NA -0.34 -8.47 -0.32 1.72e-16 Iron status biomarkers; BRCA cis rs34891900 0.507 rs2008085 chr22:18204316 T/G cg19898043 chr22:18121309 BCL2L13 0.45 9.65 0.36 1.18e-20 Sum neutrophil eosinophil counts; BRCA cis rs10504073 0.584 rs4873306 chr8:49950369 T/C cg00325661 chr8:49890786 NA 0.45 13.07 0.46 9.48e-35 Blood metabolite ratios; BRCA cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7043114 0.525 rs4744136 chr9:95275024 A/G cg14631576 chr9:95140430 CENPP 0.32 8.02 0.3 5e-15 Height; BRCA cis rs8180040 0.627 rs6442059 chr3:47187075 C/G cg16586182 chr3:47516702 SCAP -0.56 -12.53 -0.44 2.37e-32 Colorectal cancer; BRCA cis rs7927771 0.524 rs7110300 chr11:47848442 T/G cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Subjective well-being; BRCA cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11644478 chr21:40555479 PSMG1 -0.67 -14.49 -0.5 2.42e-41 Cognitive function; BRCA cis rs7666738 0.570 rs11097612 chr4:99079772 T/C cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 6.87e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs208520 0.690 rs7739253 chr6:66861052 A/G cg07460842 chr6:66804631 NA -1.02 -20.23 -0.62 1.1e-70 Exhaled nitric oxide output; BRCA cis rs208520 0.661 rs851466 chr6:66840476 A/G cg07460842 chr6:66804631 NA -1.02 -20.15 -0.62 2.95e-70 Exhaled nitric oxide output; BRCA cis rs78761021 0.867 rs17676067 chr17:9791375 C/T cg26853458 chr17:9805074 RCVRN -0.43 -8.62 -0.32 5.19e-17 Type 2 diabetes; BRCA cis rs9649465 1.000 rs10270877 chr7:123327860 T/C cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg08213375 chr14:104286397 PPP1R13B 0.65 18.58 0.59 5.9e-62 Schizophrenia; BRCA cis rs2832077 0.506 rs2832093 chr21:30164855 C/T cg24692254 chr21:30365293 RNF160 -0.46 -9.8 -0.36 3.22e-21 Cognitive test performance; BRCA cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B 0.39 8.47 0.32 1.66e-16 IgG glycosylation; BRCA trans rs61931739 0.534 rs10844728 chr12:34020109 G/C cg13010199 chr12:38710504 ALG10B 0.48 9.19 0.34 5.33e-19 Morning vs. evening chronotype; BRCA cis rs9486719 1.000 rs12210146 chr6:96903962 A/G cg06623918 chr6:96969491 KIAA0776 0.73 13.11 0.46 6.14e-35 Migraine;Coronary artery disease; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg04025307 chr7:1156635 C7orf50 0.59 13.67 0.48 1.69e-37 Longevity;Endometriosis; BRCA cis rs12142240 0.698 rs1475388 chr1:46816465 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24308560 chr3:49941425 MST1R -0.39 -8.11 -0.31 2.57e-15 Intelligence (multi-trait analysis); BRCA cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg12165864 chr7:66369176 NA -0.43 -9.66 -0.36 1.08e-20 Corneal structure; BRCA trans rs9858542 1.000 rs13316695 chr3:49684917 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.42 -9.89 -0.36 1.43e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg22920501 chr2:26401640 FAM59B -0.66 -11.43 -0.41 1.19e-27 Gut microbiome composition (summer); BRCA cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg03146154 chr1:46216737 IPP 0.47 10.52 0.38 5.5e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.94e-23 Mean platelet volume; BRCA cis rs765787 0.530 rs2433227 chr15:45517119 A/T cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.56 -0.44 1.75e-32 Personality dimensions; BRCA cis rs7572733 0.555 rs10202569 chr2:198934726 C/G cg00792783 chr2:198669748 PLCL1 0.39 8.31 0.31 5.7e-16 Dermatomyositis; BRCA cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg25173405 chr17:45401733 C17orf57 -0.53 -10.86 -0.39 2.44e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs10242455 0.702 rs45448997 chr7:99041598 G/C cg09045935 chr12:6379348 NA 0.84 8.26 0.31 8.16e-16 Blood metabolite levels; BRCA cis rs2637266 0.905 rs1978925 chr10:78399879 C/T cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg25208724 chr1:156163844 SLC25A44 0.85 16.28 0.54 4.24e-50 Testicular germ cell tumor; BRCA cis rs9462846 0.919 rs9471966 chr6:42891022 G/A cg05552183 chr6:42928497 GNMT 0.43 8.06 0.3 3.76e-15 Blood protein levels; BRCA cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg06108461 chr20:60628389 TAF4 -0.99 -22.33 -0.66 4.6e-82 Body mass index; BRCA cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs7523050 0.643 rs34096625 chr1:109401101 G/A cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs4363385 0.720 rs1338179 chr1:152981548 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.79e-16 Inflammatory skin disease; BRCA trans rs61931739 0.500 rs11053223 chr12:34481947 T/A cg26384229 chr12:38710491 ALG10B 0.75 16.82 0.55 7.58e-53 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.96 0.4 1.03e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg15112475 chr7:1198522 ZFAND2A -0.37 -7.92 -0.3 1.07e-14 Longevity;Endometriosis; BRCA cis rs7659604 0.539 rs7686200 chr4:122764553 C/T cg06713675 chr4:122721982 EXOSC9 -0.54 -12.77 -0.45 2.1e-33 Type 2 diabetes; BRCA cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg23788917 chr6:8435910 SLC35B3 -0.48 -10.42 -0.38 1.43e-23 Motion sickness; BRCA cis rs10789491 0.767 rs1816730 chr1:47207346 T/C cg15501359 chr1:47185051 KIAA0494 0.69 17.09 0.56 3.45e-54 Response to hepatitis C treatment; BRCA cis rs7822232 1.000 rs7822232 chr8:145145687 A/C cg10734432 chr8:145180544 NA -0.54 -9.05 -0.34 1.7e-18 Blood metabolite levels; BRCA trans rs9329221 0.638 rs7460436 chr8:10254322 C/T cg15556689 chr8:8085844 FLJ10661 0.35 8.38 0.31 3.45e-16 Neuroticism; BRCA cis rs2243480 1.000 rs10950032 chr7:65738591 C/A cg18252515 chr7:66147081 NA 1.04 15.68 0.53 4.14e-47 Diabetic kidney disease; BRCA cis rs7582180 0.764 rs4635546 chr2:100921125 G/A cg14675211 chr2:100938903 LONRF2 0.47 10.86 0.39 2.44e-25 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.636 rs6456698 chr6:25741664 A/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg12386194 chr3:101231763 SENP7 0.66 12.92 0.46 4.2e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg24531977 chr5:56204891 C5orf35 -0.54 -11.43 -0.41 1.22e-27 Coronary artery disease; BRCA cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg03264133 chr6:25882463 NA -0.42 -9.74 -0.36 5.23e-21 Height; BRCA cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg12560992 chr17:57184187 TRIM37 0.69 18.8 0.6 4.41e-63 Intelligence (multi-trait analysis); BRCA cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg14061069 chr19:46274453 DMPK -0.48 -11.89 -0.43 1.3e-29 Coronary artery disease; BRCA cis rs6547741 0.935 rs4666004 chr2:27855052 T/A cg27432699 chr2:27873401 GPN1 0.43 9.24 0.34 3.65e-19 Oral cavity cancer; BRCA cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg21770322 chr7:97807741 LMTK2 0.45 11.74 0.42 5.96e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs11711311 1.000 rs9855613 chr3:113448455 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -10.46 -0.38 9.96e-24 IgG glycosylation; BRCA cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg18876405 chr7:65276391 NA -0.52 -11.7 -0.42 8.87e-29 Aortic root size; BRCA cis rs7927771 0.524 rs61895760 chr11:47794538 G/C cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs2991971 0.776 rs12139364 chr1:45890155 T/C cg24296786 chr1:45957014 TESK2 0.57 13.13 0.46 4.95e-35 High light scatter reticulocyte count; BRCA cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg01819863 chr10:32635814 EPC1 1.14 20.19 0.62 1.67e-70 Sexual dysfunction (female); BRCA cis rs7301826 0.966 rs10734980 chr12:131294626 T/C cg11011512 chr12:131303247 STX2 0.42 10.89 0.4 1.91e-25 Plasma plasminogen activator levels; BRCA cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg06784218 chr1:46089804 CCDC17 -0.45 -10.74 -0.39 7.65e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6121246 0.559 rs6060962 chr20:30397847 A/G cg13852791 chr20:30311386 BCL2L1 0.95 23.04 0.67 5.81e-86 Mean corpuscular hemoglobin; BRCA cis rs35995292 0.500 rs6945239 chr7:38932208 C/T cg19327137 chr7:38886074 VPS41 0.38 12.67 0.45 5.76e-33 Subjective well-being (multi-trait analysis); BRCA cis rs8031584 0.918 rs35784593 chr15:31254588 G/A cg08109568 chr15:31115862 NA -0.45 -10.37 -0.38 2.15e-23 Huntington's disease progression; BRCA cis rs4595586 0.545 rs1156705 chr12:39372672 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs6424115 0.830 rs2503000 chr1:24197898 C/G cg15997130 chr1:24165203 NA 0.44 11.49 0.41 6.34e-28 Immature fraction of reticulocytes; BRCA trans rs2270927 0.834 rs4496693 chr5:75576729 T/C cg13563193 chr19:33072644 PDCD5 0.8 11.43 0.41 1.2e-27 Mean corpuscular volume; BRCA cis rs7312774 0.609 rs2374656 chr12:107380411 A/C cg16260113 chr12:107380972 MTERFD3 0.82 9.01 0.34 2.38e-18 Severe influenza A (H1N1) infection; BRCA cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg23505145 chr19:12996616 KLF1 0.54 12.32 0.44 1.86e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg05025164 chr4:1340916 KIAA1530 -0.71 -14.66 -0.5 3.62e-42 Longevity; BRCA cis rs11887277 0.708 rs12474330 chr2:27063260 G/A cg12368169 chr2:27073192 DPYSL5 -0.33 -10.0 -0.37 5.81e-22 Obesity-related traits; BRCA cis rs6840360 0.615 rs72728173 chr4:152469373 C/T cg25486957 chr4:152246857 NA -0.36 -7.9 -0.3 1.26e-14 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg23788917 chr6:8435910 SLC35B3 0.49 10.67 0.39 1.36e-24 Motion sickness; BRCA cis rs17376456 1.000 rs67150649 chr5:93292377 A/G cg21475434 chr5:93447410 FAM172A 0.64 8.35 0.31 4.13e-16 Diabetic retinopathy; BRCA cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 19.83 0.62 1.55e-68 Smoking behavior; BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg05863683 chr7:1912471 MAD1L1 0.36 8.27 0.31 7.83e-16 Bipolar disorder and schizophrenia; BRCA cis rs597539 0.652 rs604524 chr11:68629929 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 17.04 0.56 5.63e-54 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA trans rs2204008 0.744 rs11514358 chr12:38255526 G/A cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg02012338 chr4:187126139 CYP4V2 -0.87 -10.08 -0.37 2.87e-22 Blood protein levels; BRCA cis rs1048238 0.506 rs1262788 chr1:16215608 G/C cg21385522 chr1:16154831 NA -0.45 -9.76 -0.36 4.37e-21 Systolic blood pressure; BRCA cis rs7617773 0.778 rs11707997 chr3:48377875 A/G cg11946769 chr3:48343235 NME6 0.67 13.48 0.47 1.23e-36 Coronary artery disease; BRCA cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg08807101 chr21:30365312 RNF160 -0.6 -15.29 -0.52 3.43e-45 Dental caries; BRCA cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg12641515 chr19:46296257 DMWD -0.41 -8.59 -0.32 6.85e-17 Coronary artery disease; BRCA cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg17971929 chr21:40555470 PSMG1 -0.49 -10.84 -0.39 3.12e-25 Menarche (age at onset); BRCA trans rs7647973 0.677 rs11130211 chr3:49645209 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.95 -0.3 8.62e-15 Menarche (age at onset); BRCA trans rs7786808 0.707 rs62479983 chr7:158227613 G/A cg02030672 chr11:45687055 CHST1 0.39 8.31 0.31 5.55e-16 Obesity-related traits; BRCA trans rs11992162 0.591 rs35657308 chr8:11804402 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -9.58 -0.35 2.11e-20 Monocyte count; BRCA cis rs250677 1.000 rs250677 chr5:148433549 T/C cg12140854 chr5:148520817 ABLIM3 -0.41 -8.79 -0.33 1.39e-17 Breast cancer; BRCA cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.47 -0.38 8.63e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6860806 0.507 rs270608 chr5:131648406 C/T cg24060327 chr5:131705240 SLC22A5 -0.6 -11.09 -0.4 2.89e-26 Breast cancer; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg07930192 chr7:1003750 NA 0.39 8.26 0.31 8.12e-16 Longevity;Endometriosis; BRCA cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg10978503 chr1:24200527 CNR2 -0.43 -11.25 -0.41 6.68e-27 Immature fraction of reticulocytes; BRCA cis rs12611088 0.541 rs2599445 chr19:44005025 C/G cg15012607 chr19:44012195 ETHE1 -0.33 -8.48 -0.32 1.52e-16 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs7552404 0.731 rs7523573 chr1:76372020 G/T cg10523679 chr1:76189770 ACADM 0.72 12.38 0.44 1.03e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.515 rs28615369 chr4:98896858 C/T cg05340658 chr4:99064831 C4orf37 0.56 10.95 0.4 1.11e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs929596 0.561 rs7564935 chr2:234645186 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.4 -10.09 -0.37 2.53e-22 Total bilirubin levels in HIV-1 infection; BRCA cis rs6815814 0.950 rs56408159 chr4:38812116 T/A cg02016764 chr4:38805732 TLR1 -0.6 -9.19 -0.34 5.47e-19 Breast cancer; BRCA cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.95 21.71 0.65 1.04e-78 Smoking behavior; BRCA cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg16405210 chr4:1374714 KIAA1530 -0.53 -12.48 -0.44 3.84e-32 Longevity; BRCA cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg23422044 chr7:1970798 MAD1L1 -0.59 -11.0 -0.4 6.6900000000000006e-26 Neuroticism; BRCA cis rs7131987 0.650 rs7973786 chr12:29462744 C/T cg09582351 chr12:29534625 ERGIC2 -0.46 -10.63 -0.39 1.99e-24 QT interval; BRCA cis rs1878931 0.559 rs2106863 chr16:3391330 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.64 13.55 0.47 5.9e-37 Body mass index (adult); BRCA cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg16586182 chr3:47516702 SCAP -0.55 -12.19 -0.43 6.92e-31 Colorectal cancer; BRCA cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg15790184 chr11:494944 RNH1 0.64 9.95 0.37 8.42e-22 Body mass index; BRCA cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg10523679 chr1:76189770 ACADM 0.67 13.38 0.47 3.54e-36 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7945705 0.791 rs6484484 chr11:8817206 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.44 9.52 0.35 3.49e-20 Hemoglobin concentration; BRCA cis rs2835872 0.758 rs7278101 chr21:39035873 T/C cg06728970 chr21:39037746 KCNJ6 -0.41 -11.42 -0.41 1.23e-27 Electroencephalographic traits in alcoholism; BRCA cis rs2797160 0.935 rs60515555 chr6:126000638 T/G cg05901451 chr6:126070800 HEY2 -0.39 -9.41 -0.35 9.06e-20 Endometrial cancer; BRCA cis rs6964587 0.692 rs6953256 chr7:91575417 C/T cg17063962 chr7:91808500 NA -0.56 -12.61 -0.45 1.06e-32 Breast cancer; BRCA cis rs2404602 0.647 rs116505114 chr15:77074794 T/C cg23625390 chr15:77176239 SCAPER -0.55 -13.91 -0.48 1.28e-38 Blood metabolite levels; BRCA cis rs3749237 0.964 rs10865959 chr3:49891002 G/C cg03060546 chr3:49711283 APEH 0.46 9.59 0.35 1.95e-20 Resting heart rate; BRCA cis rs9486719 1.000 rs12197411 chr6:97039621 G/A cg06623918 chr6:96969491 KIAA0776 -0.76 -13.47 -0.47 1.45e-36 Migraine;Coronary artery disease; BRCA cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg08917208 chr2:24149416 ATAD2B 0.55 8.36 0.31 4.01e-16 Lymphocyte counts; BRCA cis rs6763687 0.856 rs13089972 chr3:171798694 T/A cg16233210 chr3:171778391 FNDC3B 0.41 9.67 0.36 9.76e-21 Red cell distribution width; BRCA cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg06582575 chr6:163149167 PACRG;PARK2 0.98 14.32 0.49 1.55e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 12.86 0.45 8.26e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7119 0.717 rs34194537 chr15:77795761 G/A cg17802220 chr15:77601643 NA -0.46 -10.12 -0.37 1.95e-22 Type 2 diabetes; BRCA cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg12463550 chr7:65579703 CRCP -0.37 -7.94 -0.3 9.28e-15 Aortic root size; BRCA cis rs11112613 0.713 rs12316204 chr12:105944244 G/A cg03607813 chr12:105948248 NA 0.6 10.99 0.4 7.33e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs10493773 0.748 rs6576784 chr1:86149476 G/A cg17807903 chr1:86174739 ZNHIT6 -0.45 -10.53 -0.38 4.91e-24 Urate levels in overweight individuals; BRCA cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg12386194 chr3:101231763 SENP7 0.46 9.65 0.36 1.17e-20 Colorectal cancer; BRCA cis rs7520050 0.966 rs2275426 chr1:46487552 G/A cg24296786 chr1:45957014 TESK2 0.44 9.84 0.36 2.35e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg24308560 chr3:49941425 MST1R -0.37 -7.88 -0.3 1.42e-14 Intelligence (multi-trait analysis); BRCA cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg02153584 chr22:29168773 CCDC117 0.53 11.05 0.4 4.09e-26 Lymphocyte counts; BRCA cis rs2011503 1.000 rs58074958 chr19:19570555 G/C cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs595982 0.559 rs117227130 chr19:49367959 A/G cg21252483 chr19:49399788 TULP2 -0.4 -9.06 -0.34 1.52e-18 Red cell distribution width; BRCA cis rs35306767 0.903 rs7914758 chr10:891702 T/C cg20503657 chr10:835505 NA 1.3 21.72 0.65 9.26e-79 Eosinophil percentage of granulocytes; BRCA cis rs9581857 0.547 rs9581881 chr13:28106637 A/G cg22138327 chr13:27999177 GTF3A 0.58 8.22 0.31 1.1e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); BRCA trans rs9951602 0.512 rs6506872 chr18:76649695 T/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.04 0.58 4.16e-59 Obesity-related traits; BRCA trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg23505145 chr19:12996616 KLF1 0.55 12.05 0.43 2.84e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg00814883 chr7:100076585 TSC22D4 -0.51 -11.56 -0.42 3.32e-28 Platelet count; BRCA cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.57 0.55 1.44e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.611 rs74661620 chr2:24365260 C/A cg20701182 chr2:24300061 SF3B14 0.71 13.15 0.46 3.99e-35 Lymphocyte counts; BRCA cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Smoking initiation; BRCA cis rs7647973 1.000 rs7613491 chr3:49508976 T/C cg07636037 chr3:49044803 WDR6 -0.77 -15.58 -0.52 1.28e-46 Menarche (age at onset); BRCA cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg18876405 chr7:65276391 NA 0.62 15.23 0.52 6.79e-45 Aortic root size; BRCA cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg18479299 chr3:125709523 NA -0.54 -8.34 -0.31 4.59e-16 Blood pressure (smoking interaction); BRCA trans rs10242455 0.557 rs45492501 chr7:99047030 T/A cg09045935 chr12:6379348 NA 0.83 8.28 0.31 7.06e-16 Blood metabolite levels; BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg08888203 chr3:10149979 C3orf24 0.58 12.09 0.43 1.95e-30 Alzheimer's disease; BRCA cis rs8010715 0.848 rs927494 chr14:24600390 A/T cg23112188 chr14:24563095 PCK2 -0.33 -8.45 -0.32 2.03e-16 IgG glycosylation; BRCA cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg12310025 chr6:25882481 NA -0.7 -17.89 -0.58 2.52e-58 Blood metabolite levels; BRCA cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs9858542 0.953 rs4625 chr3:49572140 A/G cg03060546 chr3:49711283 APEH -0.52 -10.8 -0.39 4.3e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -8.48 -0.32 1.6e-16 Glomerular filtration rate (creatinine); BRCA trans rs6089829 0.962 rs4809462 chr20:61661560 A/G cg15934090 chr1:100435551 SLC35A3 0.37 8.61 0.32 5.61e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9527 0.615 rs12248123 chr10:104735366 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.64 0.39 1.8e-24 Arsenic metabolism; BRCA cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg08085267 chr17:45401833 C17orf57 0.63 13.31 0.47 7.52e-36 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg27211696 chr2:191398769 TMEM194B 0.52 11.89 0.43 1.39e-29 Pulse pressure; BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg24531977 chr5:56204891 C5orf35 -0.89 -17.64 -0.57 5.04e-57 Initial pursuit acceleration; BRCA cis rs7772486 0.743 rs2092262 chr6:146037105 C/T cg23711669 chr6:146136114 FBXO30 -0.7 -16.89 -0.56 3.45e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs2425143 0.730 rs6579259 chr20:34462550 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.08 -0.3 3.21e-15 Blood protein levels; BRCA cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg26597838 chr10:835615 NA -0.51 -9.14 -0.34 8.07e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs7246657 0.722 rs10409605 chr19:38123137 T/G cg18154014 chr19:37997991 ZNF793 0.5 9.59 0.35 1.99e-20 Coronary artery calcification; BRCA cis rs2066819 1.000 rs79101914 chr12:56729739 A/G cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs2012796 0.956 rs6574646 chr14:81819809 A/G cg02996355 chr14:81879375 NA 0.49 9.81 0.36 2.94e-21 Night sleep phenotypes; BRCA trans rs1973993 0.691 rs1980683 chr1:96890379 A/G cg10631902 chr5:14652156 NA 0.56 19.32 0.61 7.58e-66 Weight; BRCA cis rs6594713 0.684 rs1816062 chr5:112856023 A/C cg12552261 chr5:112820674 MCC 0.5 7.91 0.3 1.16e-14 Brain cytoarchitecture; BRCA cis rs7301826 0.934 rs10773826 chr12:131321174 C/G cg11011512 chr12:131303247 STX2 0.42 10.56 0.39 3.84e-24 Plasma plasminogen activator levels; BRCA cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg15556689 chr8:8085844 FLJ10661 -0.37 -9.96 -0.37 8.04e-22 Mood instability; BRCA cis rs13102973 0.614 rs7693794 chr4:135886753 C/G cg14419869 chr4:135874104 NA -0.5 -9.78 -0.36 3.91e-21 Subjective well-being; BRCA cis rs67478160 0.643 rs2887282 chr14:104280734 A/G cg01849466 chr14:104193079 ZFYVE21 -0.42 -10.87 -0.4 2.26e-25 Schizophrenia; BRCA cis rs7727544 0.660 rs274563 chr5:131717859 C/A cg24060327 chr5:131705240 SLC22A5 0.45 8.92 0.33 4.69e-18 Blood metabolite levels; BRCA cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg16339924 chr4:17578868 LAP3 0.57 13.78 0.48 5.32e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg10802521 chr3:52805072 NEK4 -0.29 -7.97 -0.3 7.55e-15 Bipolar disorder; BRCA cis rs514406 0.929 rs555741 chr1:53318851 T/G cg25767906 chr1:53392781 SCP2 -0.39 -8.79 -0.33 1.41e-17 Monocyte count; BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg22800045 chr5:56110881 MAP3K1 0.65 12.37 0.44 1.2e-31 Initial pursuit acceleration; BRCA cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -14.09 -0.49 1.9e-39 Personality dimensions; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs2066819 1.000 rs2306694 chr12:56680636 C/T cg26734620 chr12:56694298 CS -0.87 -10.24 -0.38 6.61e-23 Psoriasis vulgaris; BRCA cis rs2276314 0.857 rs7237599 chr18:33639396 T/C cg05985134 chr18:33552581 C18orf21 0.62 11.86 0.42 1.8e-29 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1707322 0.928 rs61785614 chr1:46446047 A/G cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs16976116 0.901 rs56328329 chr15:55502977 A/T cg11288833 chr15:55489084 RSL24D1 0.47 10.57 0.39 3.46e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg23649088 chr2:200775458 C2orf69 -0.73 -16.68 -0.55 4.05e-52 Osteoporosis; BRCA cis rs11295209 1 rs11295209 chr4:120480233 TA/T cg09307838 chr4:120376055 NA -0.43 -9.08 -0.34 1.29e-18 Plateletcrit; BRCA cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg05552183 chr6:42928497 GNMT 0.48 8.34 0.31 4.6e-16 Blood protein levels; BRCA cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg22546130 chr22:19950026 COMT 0.29 9.06 0.34 1.54e-18 Blood metabolite levels; BRCA cis rs4680 0.737 rs4646312 chr22:19948337 C/T cg23601416 chr22:19950040 COMT 0.38 12.0 0.43 4.5e-30 Blood metabolite levels; BRCA cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.18e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs1701758 chr7:65470201 T/A cg18252515 chr7:66147081 NA -0.86 -12.36 -0.44 1.31e-31 Diabetic kidney disease; BRCA trans rs7618501 0.602 rs2624816 chr3:50117312 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.25 -0.34 3.36e-19 Intelligence (multi-trait analysis); BRCA trans rs6582630 0.555 rs11181657 chr12:38381858 T/C cg06521331 chr12:34319734 NA 0.43 8.26 0.31 8.33e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs4930561 0.714 rs10896300 chr11:67953772 C/T cg04465784 chr11:67976953 SUV420H1 0.26 8.63 0.32 4.98e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs6964587 0.869 rs11769726 chr7:91485231 A/G cg17063962 chr7:91808500 NA -0.52 -11.75 -0.42 5.13e-29 Breast cancer; BRCA cis rs7904368 0.568 rs7075036 chr10:16864810 C/T cg23933602 chr10:16859644 RSU1 0.7 16.39 0.54 1.21e-50 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11890956 chr21:40555474 PSMG1 1.06 29.9 0.76 1.51e-123 Cognitive function; BRCA cis rs4812048 0.901 rs151354 chr20:57606971 A/G cg14073986 chr20:57617431 SLMO2 0.46 8.72 0.33 2.46e-17 Mean platelet volume; BRCA cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg11663144 chr21:46675770 NA -0.59 -14.01 -0.48 4.47e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9649213 0.727 rs12113294 chr7:97910637 C/G cg09267113 chr7:98030324 BAIAP2L1 0.36 9.53 0.35 3.13e-20 Prostate cancer (SNP x SNP interaction); BRCA cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg21918786 chr6:109611834 NA -0.49 -14.14 -0.49 1.03e-39 Reticulocyte fraction of red cells; BRCA cis rs2012796 0.743 rs12435764 chr14:81836866 A/C cg02996355 chr14:81879375 NA 0.53 10.83 0.39 3.18e-25 Night sleep phenotypes; BRCA cis rs9733 0.818 rs12130363 chr1:150688596 T/C cg18016565 chr1:150552671 MCL1 -0.41 -9.43 -0.35 7.2e-20 Tonsillectomy; BRCA cis rs2742234 0.541 rs10899778 chr10:43718509 G/C cg02780029 chr10:43622663 RET 0.35 7.86 0.3 1.67e-14 Hirschsprung disease; BRCA cis rs1707322 0.655 rs3014240 chr1:46089225 C/G cg06784218 chr1:46089804 CCDC17 -0.53 -12.86 -0.45 8.4e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg13010199 chr12:38710504 ALG10B -0.41 -8.94 -0.33 4.28e-18 Bladder cancer; BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg02951883 chr7:2050386 MAD1L1 -0.49 -10.82 -0.39 3.55e-25 Bipolar disorder and schizophrenia; BRCA cis rs2832077 0.943 rs11701445 chr21:30160807 C/T cg08807101 chr21:30365312 RNF160 -0.44 -7.82 -0.3 2.25e-14 Cognitive test performance; BRCA cis rs5758659 0.652 rs5758537 chr22:42397042 G/T cg05082376 chr22:42548792 NA -0.31 -7.86 -0.3 1.59e-14 Cognitive function; BRCA cis rs1829883 1.000 rs1523381 chr5:98773754 T/C cg08333243 chr5:99726346 NA -0.36 -8.56 -0.32 8.5e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs1153858 1.000 rs4775909 chr15:45643042 T/C cg21132104 chr15:45694354 SPATA5L1 0.7 15.36 0.52 1.52e-45 Homoarginine levels; BRCA cis rs6570726 0.846 rs6914304 chr6:145921017 T/C cg23711669 chr6:146136114 FBXO30 0.71 16.82 0.55 7.91e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg15017067 chr4:17643749 FAM184B 0.29 8.8 0.33 1.32e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg16680214 chr1:154839983 KCNN3 -0.45 -12.46 -0.44 4.89e-32 Prostate cancer; BRCA cis rs514406 0.708 rs536621 chr1:53309097 A/G cg24675658 chr1:53192096 ZYG11B -0.68 -15.32 -0.52 2.46e-45 Monocyte count; BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg04518342 chr5:131593106 PDLIM4 0.37 9.25 0.34 3.29e-19 Breast cancer; BRCA cis rs6500602 0.627 rs934929 chr16:4587789 A/G cg08645402 chr16:4508243 NA -0.37 -8.85 -0.33 8.59e-18 Schizophrenia; BRCA cis rs7553864 0.636 rs7543740 chr1:87609026 C/T cg17420885 chr1:87600446 LOC339524 -0.44 -9.06 -0.34 1.52e-18 Smoking behavior; BRCA cis rs78707713 0.560 rs55668536 chr10:71242655 A/G cg12610070 chr10:71211762 TSPAN15 -0.33 -10.35 -0.38 2.6e-23 Venous thromboembolism; BRCA cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg08999081 chr20:33150536 PIGU -0.47 -12.84 -0.45 9.74e-34 Glomerular filtration rate (creatinine); BRCA cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg21535247 chr6:8435926 SLC35B3 -0.38 -8.55 -0.32 8.8e-17 Motion sickness; BRCA cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg19077165 chr18:44547161 KATNAL2 -0.53 -11.45 -0.41 9.82e-28 Personality dimensions; BRCA cis rs4595586 0.525 rs7977228 chr12:39395060 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA trans rs10506458 1.000 rs12580997 chr12:63433420 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.16 -17.75 -0.57 1.34e-57 Hemostatic factors and hematological phenotypes; BRCA cis rs9467773 1.000 rs2208331 chr6:26507319 A/G cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.21e-20 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.738 rs28687057 chr4:120280812 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA trans rs11098499 0.909 rs28884220 chr4:120307211 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA trans rs141342723 1 rs141342723 chr6:27622084 T/C cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.96e-23 Autism spectrum disorder or schizophrenia; BRCA cis rs698833 0.886 rs2289463 chr2:44565447 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.6 0.39 2.66e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs425277 0.958 rs262687 chr1:2117155 G/A cg00981070 chr1:2046702 PRKCZ 0.3 7.88 0.3 1.38e-14 Height; BRCA cis rs477895 0.713 rs12575642 chr11:63979643 G/T cg18225595 chr11:63971243 STIP1 0.54 9.91 0.37 1.23e-21 Mean platelet volume; BRCA cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00166722 chr3:10149974 C3orf24 0.58 11.74 0.42 5.71e-29 Alzheimer's disease; BRCA cis rs4242434 0.927 rs11781149 chr8:22473158 C/T cg03733263 chr8:22462867 KIAA1967 1.0 21.1 0.64 2.03e-75 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs600231 0.542 rs10896009 chr11:65246054 A/G cg01292856 chr11:65242576 NA -0.61 -14.31 -0.49 1.68e-40 Bone mineral density; BRCA cis rs813218 0.584 rs11711935 chr3:99808804 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 8.71 0.33 2.64e-17 Orofacial clefts; BRCA cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11890956 chr21:40555474 PSMG1 1.09 33.73 0.8 5.05e-144 Cognitive function; BRCA cis rs10493773 0.674 rs414618 chr1:86220418 G/A cg17807903 chr1:86174739 ZNHIT6 0.42 10.4 0.38 1.65e-23 Urate levels in overweight individuals; BRCA cis rs11123610 0.520 rs35482526 chr2:3720707 C/G cg19052272 chr2:3704530 ALLC -0.49 -10.69 -0.39 1.2e-24 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2276314 0.857 rs16967327 chr18:33587036 C/T cg05985134 chr18:33552581 C18orf21 0.64 12.16 0.43 9.75e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs35306767 0.623 rs36051896 chr10:1155747 T/C cg26597838 chr10:835615 NA 0.69 11.03 0.4 5.08e-26 Eosinophil percentage of granulocytes; BRCA cis rs738322 0.839 rs133015 chr22:38572526 C/G cg25457927 chr22:38595422 NA -0.41 -15.41 -0.52 8.48e-46 Cutaneous nevi; BRCA cis rs9527 0.590 rs10509764 chr10:104776475 G/A cg04362960 chr10:104952993 NT5C2 0.44 9.92 0.37 1.15e-21 Arsenic metabolism; BRCA cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg20573242 chr4:122745356 CCNA2 0.49 10.96 0.4 9.98e-26 Type 2 diabetes; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg23708337 chr7:1209742 NA 0.55 9.34 0.35 1.53e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9682041 0.877 rs10755126 chr3:170071694 C/G cg11886554 chr3:170076028 SKIL -0.52 -10.65 -0.39 1.75e-24 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg24879335 chr3:133465180 TF 0.25 7.81 0.3 2.42e-14 Iron status biomarkers; BRCA cis rs1577917 1.000 rs12663651 chr6:86701655 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.77 -0.42 4.5e-29 Response to antipsychotic treatment; BRCA trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.62 0.47 2.98e-37 Morning vs. evening chronotype; BRCA trans rs911555 0.723 rs7144010 chr14:103869869 G/A cg17675199 chr6:35436792 RPL10A -0.29 -7.82 -0.3 2.21e-14 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.749 rs4579984 chr12:38166266 A/G cg06521331 chr12:34319734 NA -0.53 -10.08 -0.37 2.83e-22 Bladder cancer; BRCA cis rs6977660 0.714 rs12666488 chr7:19788403 G/A cg07541023 chr7:19748670 TWISTNB 0.57 9.71 0.36 6.69e-21 Thyroid stimulating hormone; BRCA cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg24812749 chr6:127587940 RNF146 0.85 19.76 0.62 3.28e-68 Breast cancer; BRCA cis rs2580764 0.678 rs2588521 chr2:55203931 C/G cg09592903 chr2:55203963 RTN4 0.43 10.97 0.4 9.07e-26 Mean platelet volume; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg09877947 chr5:131593287 PDLIM4 -0.41 -10.3 -0.38 3.88e-23 Breast cancer; BRCA cis rs10754283 0.967 rs6428561 chr1:90102619 G/A cg21401794 chr1:90099060 LRRC8C 0.46 11.11 0.4 2.33e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2742540 0.503 rs982273 chr11:8906862 T/G cg12365402 chr11:9010492 NRIP3 -0.37 -8.02 -0.3 5.04e-15 Hematocrit; BRCA cis rs6728642 0.908 rs10203833 chr2:98017363 G/A cg26665480 chr2:98280029 ACTR1B -0.53 -8.8 -0.33 1.3e-17 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg02175503 chr12:58329896 NA -0.58 -13.43 -0.47 2.1e-36 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.714 rs2051540 chr6:25947197 T/C cg03517284 chr6:25882590 NA -0.51 -10.82 -0.39 3.55e-25 Intelligence (multi-trait analysis); BRCA cis rs523522 0.962 rs670568 chr12:121021206 C/T cg12219531 chr12:120966889 COQ5 0.55 11.61 0.42 2.02e-28 High light scatter reticulocyte count; BRCA cis rs4481887 0.679 rs4466692 chr1:248423174 C/G cg00666640 chr1:248458726 OR2T12 0.28 7.87 0.3 1.53e-14 Common traits (Other); BRCA cis rs7666738 0.830 rs17550735 chr4:99014076 T/G cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs911119 0.866 rs6048920 chr20:23576844 A/G cg16589663 chr20:23618590 CST3 0.4 7.9 0.3 1.25e-14 Chronic kidney disease; BRCA cis rs250677 0.958 rs17109282 chr5:148416677 A/G cg18129178 chr5:148520854 ABLIM3 0.58 11.82 0.42 2.68e-29 Breast cancer; BRCA cis rs7727544 0.582 rs3749756 chr5:131534499 C/T cg14196790 chr5:131705035 SLC22A5 0.38 9.26 0.34 2.98e-19 Blood metabolite levels; BRCA trans rs11098499 0.863 rs3775841 chr4:120425777 A/C cg25214090 chr10:38739885 LOC399744 0.55 12.08 0.43 2.18e-30 Corneal astigmatism; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg18402987 chr7:1209562 NA 0.65 14.25 0.49 3.34e-40 Longevity;Endometriosis; BRCA cis rs1949733 0.701 rs4696828 chr4:8455604 G/A cg11789530 chr4:8429930 ACOX3 -0.6 -14.98 -0.51 1.03e-43 Response to antineoplastic agents; BRCA cis rs3008870 0.755 rs2815364 chr1:67498384 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 13.19 0.46 2.52e-35 Lymphocyte percentage of white cells; BRCA trans rs877282 0.700 rs816311 chr10:796490 C/A cg22713356 chr15:30763199 NA 1.1 22.04 0.66 1.71e-80 Uric acid levels; BRCA cis rs4363385 0.747 rs4568784 chr1:152972694 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.22 -0.31 1.11e-15 Inflammatory skin disease; BRCA cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg22535103 chr8:58192502 C8orf71 -0.58 -12.66 -0.45 5.89e-33 Developmental language disorder (linguistic errors); BRCA cis rs28830936 1.000 rs17677991 chr15:42032383 C/G cg17847044 chr15:42102381 MAPKBP1 -0.37 -11.36 -0.41 2.25e-27 Diastolic blood pressure; BRCA cis rs6461049 0.638 rs3778994 chr7:2175855 G/T cg04267008 chr7:1944627 MAD1L1 -0.39 -8.32 -0.31 5.24e-16 Schizophrenia; BRCA cis rs7737355 0.898 rs3775999 chr5:130970090 T/C cg06307176 chr5:131281290 NA 0.53 9.9 0.36 1.35e-21 Life satisfaction; BRCA cis rs9914988 0.943 rs2046759 chr17:27138817 T/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.8 -0.33 1.31e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg11833968 chr6:79620685 NA -0.44 -9.89 -0.36 1.48e-21 Intelligence (multi-trait analysis); BRCA cis rs9815354 0.812 rs73069203 chr3:41938767 T/C cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.71e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs9399135 0.935 rs987690 chr6:135350379 A/G cg24558204 chr6:135376177 HBS1L 0.44 12.17 0.43 8.77e-31 Red blood cell count; BRCA cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg17366294 chr4:99064904 C4orf37 0.41 9.74 0.36 5.2e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs3815700 1.000 rs7260624 chr19:33096562 A/G cg02997394 chr19:33096574 ANKRD27 0.7 12.01 0.43 4.15e-30 Eosinophilic esophagitis; BRCA cis rs68092024 0.704 rs793487 chr3:99495422 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.49 -0.38 7.01e-24 Cleft lip with or without cleft palate; BRCA cis rs17376456 0.877 rs10476598 chr5:93367281 C/T cg21475434 chr5:93447410 FAM172A -0.68 -9.0 -0.34 2.6e-18 Diabetic retinopathy; BRCA cis rs6132905 0.520 rs2422823 chr20:2646333 C/A cg01629329 chr20:2633258 NOP56;MIR1292 0.4 7.89 0.3 1.33e-14 Mumps; BRCA cis rs2404602 0.735 rs3765115 chr15:76673716 T/C cg23625390 chr15:77176239 SCAPER -0.53 -13.12 -0.46 5.26e-35 Blood metabolite levels; BRCA cis rs9296092 0.538 rs9296094 chr6:33520064 A/G cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2204008 0.840 rs11181795 chr12:38401129 A/G cg13010199 chr12:38710504 ALG10B 0.5 10.3 0.38 4.14e-23 Bladder cancer; BRCA cis rs9796 0.621 rs537244 chr15:41469313 G/T cg18705301 chr15:41695430 NDUFAF1 0.37 7.92 0.3 1.03e-14 Menopause (age at onset); BRCA cis rs6782228 0.675 rs56141228 chr3:128386042 C/T cg16766828 chr3:128327626 NA -0.43 -9.49 -0.35 4.55e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs13102973 0.965 rs28769289 chr4:135878230 T/C cg14419869 chr4:135874104 NA -0.59 -13.01 -0.46 1.7e-34 Subjective well-being; BRCA cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg08000102 chr2:233561755 GIGYF2 0.64 13.86 0.48 2.19e-38 Coronary artery disease; BRCA cis rs775227 0.574 rs60131925 chr3:113034768 T/C cg18753928 chr3:113234510 CCDC52 -0.54 -9.2 -0.34 4.83e-19 Dental caries; BRCA cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg11941060 chr3:133502564 NA -0.49 -11.8 -0.42 3.32e-29 Iron status biomarkers; BRCA cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA trans rs7824557 0.767 rs7003241 chr8:11169075 A/G cg15556689 chr8:8085844 FLJ10661 0.37 8.66 0.32 3.97e-17 Retinal vascular caliber; BRCA trans rs35110281 0.782 rs4818856 chr21:45043495 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.37 0.38 2.16e-23 Mean corpuscular volume; BRCA cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg22455342 chr2:225449267 CUL3 0.64 16.8 0.55 1.01e-52 IgE levels in asthmatics (D.p. specific); BRCA cis rs614226 0.744 rs787832 chr12:120986801 A/G cg01236616 chr12:121019343 POP5 1.24 27.13 0.73 1.9e-108 Type 1 diabetes nephropathy; BRCA cis rs7903847 0.642 rs2275089 chr10:99141205 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA trans rs11098499 0.863 rs9884402 chr4:120489982 A/G cg25214090 chr10:38739885 LOC399744 0.52 11.52 0.41 4.81e-28 Corneal astigmatism; BRCA cis rs924607 1.000 rs1697978 chr5:642829 A/G cg24163568 chr5:669837 TPPP 0.35 9.65 0.36 1.19e-20 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs7904368 0.659 rs3740169 chr10:16873547 C/T cg23933602 chr10:16859644 RSU1 0.56 11.1 0.4 2.61e-26 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.08 -0.3 3.26e-15 Total body bone mineral density; BRCA cis rs2762353 0.806 rs6909187 chr6:25785925 C/T cg03517284 chr6:25882590 NA 0.39 9.12 0.34 9.82e-19 Blood metabolite levels; BRCA cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs34779708 0.966 rs4934734 chr10:35434373 T/C cg03585969 chr10:35415529 CREM 0.56 11.6 0.42 2.21e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10876993 0.890 rs10783844 chr12:58098425 A/C cg18357645 chr12:58087776 OS9 0.46 13.24 0.46 1.63e-35 Celiac disease or Rheumatoid arthritis; BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 15.12 0.51 2.33e-44 Platelet count; BRCA cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg14019146 chr3:50243930 SLC38A3 -0.4 -9.79 -0.36 3.63e-21 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg06238570 chr21:40685208 BRWD1 -0.43 -8.67 -0.32 3.51e-17 Cognitive function; BRCA cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg00290607 chr11:67383545 NA 0.52 11.7 0.42 8.65e-29 Mean corpuscular volume; BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg27170947 chr2:26402098 FAM59B -0.66 -11.29 -0.41 4.62e-27 Gut microbiome composition (summer); BRCA cis rs17095355 1.000 rs921351 chr10:111704715 A/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.15 -0.37 1.5e-22 Biliary atresia; BRCA cis rs11098499 0.954 rs7656252 chr4:120404268 T/C cg09307838 chr4:120376055 NA 0.72 15.28 0.52 3.69e-45 Corneal astigmatism; BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg02951883 chr7:2050386 MAD1L1 0.39 9.4 0.35 9.2e-20 Bipolar disorder and schizophrenia; BRCA cis rs11920090 0.858 rs11717435 chr3:170691812 G/A cg09710316 chr3:170744871 SLC2A2 0.51 8.2 0.31 1.35e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs870825 0.616 rs12498890 chr4:185636096 C/G cg04058563 chr4:185651563 MLF1IP -0.79 -17.59 -0.57 9.04e-57 Blood protein levels; BRCA cis rs2985684 0.948 rs11623263 chr14:50083295 A/G cg04989706 chr14:50066350 PPIL5 -0.47 -8.74 -0.33 2.03e-17 Carotid intima media thickness; BRCA cis rs9287719 0.967 rs12995602 chr2:10753542 C/A cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg01475377 chr6:109611718 NA -0.56 -15.13 -0.51 1.98e-44 Reticulocyte fraction of red cells; BRCA cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg26384229 chr12:38710491 ALG10B 0.69 16.25 0.54 6.24e-50 Drug-induced liver injury (flucloxacillin); BRCA trans rs61931739 0.513 rs1486889 chr12:33901229 A/G cg26384229 chr12:38710491 ALG10B 0.48 11.06 0.4 3.81e-26 Morning vs. evening chronotype; BRCA cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.9 0.43 1.27e-29 Lung cancer in ever smokers; BRCA trans rs801193 1.000 rs10252765 chr7:66228732 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.39 0.32 3.21e-16 Aortic root size; BRCA cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg23711669 chr6:146136114 FBXO30 0.84 20.31 0.63 3.87e-71 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 0.806 rs4519744 chr3:134321523 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs208520 0.837 rs208498 chr6:66931560 G/A cg07460842 chr6:66804631 NA -0.81 -14.56 -0.5 1.15e-41 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs10010223 chr4:99021758 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg22972055 chr7:872293 UNC84A 0.37 8.29 0.31 6.45e-16 Cerebrospinal P-tau181p levels; BRCA cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.29 0.49 2.05e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs225245 0.541 rs321613 chr17:33881718 G/A cg19694781 chr19:47549865 TMEM160 -0.41 -9.28 -0.34 2.6e-19 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg07138768 chr7:917805 C7orf20 0.28 8.21 0.31 1.19e-15 Perceived unattractiveness to mosquitoes; BRCA cis rs11984145 1.000 rs11982889 chr7:38838948 C/T cg19327137 chr7:38886074 VPS41 0.44 8.39 0.32 3.1e-16 Cognitive performance; BRCA cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.12 0.43 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6433895 0.961 rs11891215 chr2:182010027 A/G cg00481216 chr2:181971175 NA 0.38 8.75 0.33 1.9e-17 Lymphocyte counts; BRCA cis rs72634258 0.554 rs34305100 chr1:7913029 A/G cg26816564 chr1:7831052 VAMP3 0.55 10.49 0.38 7.55e-24 Inflammatory bowel disease; BRCA cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg18016565 chr1:150552671 MCL1 -0.43 -9.93 -0.37 1.08e-21 Tonsillectomy; BRCA cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg24130564 chr14:104152367 KLC1 -0.41 -8.81 -0.33 1.19e-17 Reticulocyte count; BRCA cis rs9291683 0.552 rs17187075 chr4:9990328 G/C cg02734326 chr4:10020555 SLC2A9 0.37 8.16 0.31 1.78e-15 Bone mineral density; BRCA trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.09 0.3 2.99e-15 Corneal astigmatism; BRCA cis rs12682352 0.602 rs635594 chr8:8613387 C/T cg15556689 chr8:8085844 FLJ10661 -0.32 -8.16 -0.31 1.82e-15 Neuroticism; BRCA cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg27165867 chr14:105738592 BRF1 -0.35 -8.3 -0.31 6.1e-16 Mean platelet volume;Platelet distribution width; BRCA trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 7.81 0.3 2.34e-14 Corneal astigmatism; BRCA cis rs7267979 1.000 rs2500405 chr20:25360826 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.58 0.39 3.18e-24 Chronic sinus infection; BRCA cis rs644148 0.704 rs2686761 chr19:44989752 T/C cg15540054 chr19:45004280 ZNF180 -0.5 -9.78 -0.36 3.87e-21 Personality dimensions; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.69 14.59 0.5 7.58e-42 Lymphocyte counts; BRCA cis rs875971 0.545 rs10950036 chr7:65818228 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 9.99 0.37 6.37e-22 Aortic root size; BRCA cis rs4919087 0.810 rs1572437 chr10:99029278 A/G cg25902810 chr10:99078978 FRAT1 0.42 9.13 0.34 8.71e-19 Monocyte count; BRCA cis rs887829 0.641 rs7586110 chr2:234590527 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.53 -0.32 1.09e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs11945232 1.000 rs4314250 chr4:88340969 A/G cg23841344 chr4:88312519 HSD17B11 0.47 9.16 0.34 7.14e-19 Intelligence (multi-trait analysis); BRCA cis rs2816062 0.965 rs2816061 chr1:18903819 A/G cg18795169 chr1:18902165 NA 0.87 23.24 0.68 4.47e-87 Urate levels in lean individuals; BRCA cis rs7582720 0.943 rs114372659 chr2:203715514 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.79 12.51 0.44 2.8e-32 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs586533 0.846 rs1690817 chr11:99496812 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs919433 0.680 rs6434934 chr2:198437386 C/G cg00792783 chr2:198669748 PLCL1 0.35 8.18 0.31 1.53e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 11.31 0.41 3.67e-27 Platelet count; BRCA cis rs2624839 0.704 rs13067082 chr3:50221715 A/G cg24110177 chr3:50126178 RBM5 0.46 11.93 0.43 8.77e-30 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.666 rs7943140 chr11:973824 T/C cg10932868 chr11:921992 NA 0.48 12.14 0.43 1.13e-30 Alzheimer's disease (late onset); BRCA cis rs495337 0.760 rs6067270 chr20:48537254 T/C cg17835207 chr20:48524531 SPATA2 -0.69 -16.83 -0.55 7.01e-53 Psoriasis; BRCA cis rs35146811 0.538 rs3823642 chr7:99796072 T/C cg13334819 chr7:99746414 C7orf59 -0.34 -7.96 -0.3 7.71e-15 Coronary artery disease; BRCA cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg21132104 chr15:45694354 SPATA5L1 0.75 16.78 0.55 1.22e-52 Homoarginine levels; BRCA cis rs6424115 1.000 rs4237 chr1:24114129 C/T cg10978503 chr1:24200527 CNR2 0.45 11.62 0.42 1.96e-28 Immature fraction of reticulocytes; BRCA cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg25019033 chr10:957182 NA -0.42 -8.9 -0.33 5.57e-18 Eosinophil percentage of granulocytes; BRCA cis rs6121246 0.909 rs6089071 chr20:30378384 C/G cg21427119 chr20:30132790 HM13 -0.42 -8.82 -0.33 1.05e-17 Mean corpuscular hemoglobin; BRCA cis rs11098499 0.865 rs10213221 chr4:120255926 G/A cg09307838 chr4:120376055 NA 0.63 13.65 0.48 2.17e-37 Corneal astigmatism; BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg20607798 chr8:58055168 NA 0.54 8.35 0.31 4.37e-16 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.660 rs10281080 chr7:66042441 T/C cg18876405 chr7:65276391 NA -0.62 -15.42 -0.52 7.35e-46 Aortic root size; BRCA cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg19077165 chr18:44547161 KATNAL2 0.58 12.99 0.46 2.03e-34 Personality dimensions; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg18765753 chr7:1198926 ZFAND2A 0.36 7.92 0.3 1.08e-14 Longevity;Endometriosis; BRCA cis rs113835537 0.559 rs11227497 chr11:66269464 T/C cg24851651 chr11:66362959 CCS 0.44 8.39 0.32 3.05e-16 Airway imaging phenotypes; BRCA cis rs7666738 0.830 rs11097605 chr4:98985167 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs832540 0.656 rs832567 chr5:56152416 C/A cg24531977 chr5:56204891 C5orf35 -0.54 -11.4 -0.41 1.49e-27 Coronary artery disease; BRCA cis rs9467773 1.000 rs6933176 chr6:26540178 G/A cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg05025164 chr4:1340916 KIAA1530 0.39 8.54 0.32 9.95e-17 Longevity; BRCA cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg18867708 chr6:26865862 GUSBL1 -0.41 -7.85 -0.3 1.79e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs13102973 0.899 rs10212820 chr4:135899842 G/T cg14419869 chr4:135874104 NA -0.52 -10.64 -0.39 1.89e-24 Subjective well-being; BRCA cis rs698833 0.926 rs1085449 chr2:44653432 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.48 10.02 0.37 4.63e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg05283184 chr6:79620031 NA -0.43 -11.06 -0.4 3.83e-26 Intelligence (multi-trait analysis); BRCA cis rs9653442 0.609 rs10209110 chr2:100672692 C/T cg22139774 chr2:100720529 AFF3 -0.29 -8.06 -0.3 3.85e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs2806561 0.964 rs683052 chr1:23514953 T/C cg19743168 chr1:23544995 NA 0.43 10.59 0.39 2.92e-24 Height; BRCA cis rs3815700 1.000 rs8109885 chr19:33095557 A/G cg02997394 chr19:33096574 ANKRD27 0.69 11.39 0.41 1.69e-27 Eosinophilic esophagitis; BRCA cis rs28374715 0.532 rs28535540 chr15:41659277 G/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -26.3 -0.72 7.48e-104 Ulcerative colitis; BRCA cis rs908922 0.676 rs7530609 chr1:152526812 C/A cg20991723 chr1:152506922 NA 0.37 8.29 0.31 6.61e-16 Hair morphology; BRCA cis rs2652834 0.851 rs16946416 chr15:63356721 A/T cg05507819 chr15:63340323 TPM1 -0.54 -9.24 -0.34 3.7e-19 HDL cholesterol; BRCA cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg18016565 chr1:150552671 MCL1 0.35 8.22 0.31 1.13e-15 Tonsillectomy; BRCA cis rs56116382 0.605 rs12715435 chr3:49338992 G/A cg03060546 chr3:49711283 APEH -0.52 -7.88 -0.3 1.4e-14 Intelligence (multi-trait analysis);High light scatter reticulocyte count; BRCA cis rs9646954 0.542 rs4149513 chr2:101022726 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.85 -0.3 1.72e-14 Intelligence (multi-trait analysis); BRCA cis rs9633740 0.947 rs7096909 chr10:82284512 A/T cg01528321 chr10:82214614 TSPAN14 -1.07 -20.35 -0.63 2.25e-71 Post bronchodilator FEV1; BRCA trans rs79976124 0.797 rs78317899 chr6:66652896 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.61 10.82 0.39 3.51e-25 Type 2 diabetes; BRCA cis rs11098499 0.754 rs11098502 chr4:120252063 T/A cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.15 -0.31 1.89e-15 Total body bone mineral density; BRCA trans rs11039798 0.764 rs4357721 chr11:48354907 G/A cg15704280 chr7:45808275 SEPT13 -0.56 -8.55 -0.32 9.4e-17 Axial length; BRCA cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg08603382 chr10:743973 NA -0.45 -8.35 -0.31 4.28e-16 Psychosis in Alzheimer's disease; BRCA cis rs7914558 0.966 rs10748835 chr10:104660256 C/T cg04362960 chr10:104952993 NT5C2 0.41 10.03 0.37 4.49e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs66887589 0.616 rs11732621 chr4:120212883 A/C cg25214090 chr10:38739885 LOC399744 0.38 8.7 0.33 2.9e-17 Diastolic blood pressure; BRCA cis rs9814567 0.806 rs4955526 chr3:134317337 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.53 -16.9 -0.56 3.11e-53 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.58 12.62 0.45 9.35e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg08470875 chr2:26401718 FAM59B -0.51 -8.17 -0.31 1.62e-15 Gut microbiome composition (summer); BRCA cis rs9381107 0.932 rs9380624 chr6:9418725 A/C cg14735645 chr6:9486422 NA -0.47 -8.22 -0.31 1.11e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2742234 0.955 rs2075913 chr10:43622368 T/A cg15436174 chr10:43711423 RASGEF1A -0.41 -8.64 -0.32 4.48e-17 Hirschsprung disease; BRCA cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg25237894 chr2:233734115 C2orf82 0.39 11.33 0.41 3.13e-27 Coronary artery disease; BRCA cis rs7903847 0.642 rs7088410 chr10:99135539 G/T cg08345082 chr10:99160200 RRP12 -0.29 -8.6 -0.32 6.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7512552 0.839 rs2873669 chr1:150426224 C/T cg15654264 chr1:150340011 RPRD2 -0.42 -9.03 -0.34 2.02e-18 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs6942756 0.713 rs691807 chr7:129076203 G/C cg02491457 chr7:128862824 NA -0.53 -10.76 -0.39 6.52e-25 White matter hyperintensity burden; BRCA cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg12927641 chr6:109611667 NA -0.42 -10.9 -0.4 1.8e-25 Reticulocyte fraction of red cells; BRCA cis rs4481887 1.000 rs4457616 chr1:248492198 A/G cg00666640 chr1:248458726 OR2T12 0.34 8.88 0.33 6.87e-18 Common traits (Other); BRCA cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg09314803 chr17:79180344 AZI1 -0.36 -9.1 -0.34 1.1e-18 Frontotemporal dementia; BRCA cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.98e-16 Menopause (age at onset); BRCA cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg07493874 chr5:1342172 CLPTM1L -0.51 -14.94 -0.51 1.72e-43 Lung cancer; BRCA cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg25427524 chr10:38739819 LOC399744 -0.74 -18.27 -0.59 2.48e-60 Extrinsic epigenetic age acceleration; BRCA cis rs758324 0.947 rs173812 chr5:131319460 A/G cg06307176 chr5:131281290 NA -0.5 -9.92 -0.37 1.11e-21 Alzheimer's disease in APOE e4- carriers; BRCA cis rs6138458 0.816 rs2151463 chr20:24911819 A/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.36 -0.31 3.95e-16 Blood protein levels; BRCA cis rs13217239 0.646 rs7768407 chr6:27016795 G/A cg12292205 chr6:26970375 C6orf41 0.56 12.47 0.44 4.11e-32 Schizophrenia; BRCA cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg27279351 chr12:120934652 DYNLL1 0.56 13.13 0.46 4.75e-35 High light scatter reticulocyte count; BRCA cis rs4880487 0.888 rs72760998 chr10:1251203 T/C cg03183215 chr10:1252341 ADARB2 -0.42 -8.41 -0.32 2.77e-16 Migraine; BRCA cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1113500 0.748 rs1781048 chr1:108555050 A/T cg06207961 chr1:108661230 NA 0.34 7.99 0.3 6.29e-15 Growth-regulated protein alpha levels; BRCA cis rs7553864 0.667 rs7512650 chr1:87609076 T/C cg17420885 chr1:87600446 LOC339524 -0.44 -9.1 -0.34 1.16e-18 Smoking behavior; BRCA cis rs611744 0.631 rs627392 chr8:109254677 C/T cg21045802 chr8:109455806 TTC35 0.35 8.03 0.3 4.64e-15 Dupuytren's disease; BRCA cis rs796364 1.000 rs281774 chr2:200814572 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.8 13.46 0.47 1.5e-36 Schizophrenia; BRCA cis rs911119 0.954 rs2424582 chr20:23622550 A/G cg16589663 chr20:23618590 CST3 0.41 7.82 0.3 2.27e-14 Chronic kidney disease; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg21226059 chr5:178986404 RUFY1 -0.5 -14.36 -0.49 9.44e-41 Lung cancer; BRCA cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg22563815 chr15:78856949 CHRNA5 0.34 7.88 0.3 1.41e-14 Sudden cardiac arrest; BRCA cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg08999081 chr20:33150536 PIGU 0.38 9.67 0.36 9.62e-21 Coronary artery disease; BRCA trans rs453301 0.571 rs330048 chr8:9087278 A/C cg08975724 chr8:8085496 FLJ10661 -0.4 -8.82 -0.33 1.1e-17 Joint mobility (Beighton score); BRCA cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg22875332 chr1:76189707 ACADM 0.66 11.78 0.42 3.81e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1691799 0.867 rs1168330 chr12:66763167 C/T cg16791601 chr12:66731901 HELB 0.64 16.5 0.55 3.45e-51 White blood cell count (basophil); BRCA trans rs4718428 0.672 rs12530806 chr7:66390724 A/G cg18876405 chr7:65276391 NA 0.44 8.55 0.32 8.86e-17 Corneal structure; BRCA cis rs6831352 0.918 rs29001195 chr4:100054244 G/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA trans rs57221529 0.563 rs4957057 chr5:569230 C/G cg25482853 chr8:67687455 SGK3 0.79 13.58 0.47 4.15e-37 Lung disease severity in cystic fibrosis; BRCA cis rs7246657 0.525 rs10405238 chr19:37488055 T/G cg18154014 chr19:37997991 ZNF793 0.49 8.38 0.31 3.31e-16 Coronary artery calcification; BRCA trans rs6951245 0.678 rs28600085 chr7:1169636 C/T cg13565492 chr6:43139072 SRF -0.81 -12.58 -0.45 1.34e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2072499 0.750 rs72708291 chr1:156177285 A/T cg25208724 chr1:156163844 SLC25A44 0.85 17.0 0.56 9.78e-54 Testicular germ cell tumor; BRCA cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg22920501 chr2:26401640 FAM59B -0.67 -11.56 -0.42 3.5e-28 Gut microbiome composition (summer); BRCA cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg15352829 chr14:105391018 PLD4 -0.38 -12.42 -0.44 6.89e-32 Rheumatoid arthritis; BRCA cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.15e-23 Motion sickness; BRCA cis rs651907 0.535 rs12633089 chr3:101528763 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.48 0.47 1.21e-36 Colorectal cancer; BRCA cis rs12200560 0.505 rs211164 chr6:97068140 G/T cg06623918 chr6:96969491 KIAA0776 0.51 11.93 0.43 9.45e-30 Coronary heart disease; BRCA cis rs7772486 0.875 rs9399573 chr6:146403255 A/T cg23711669 chr6:146136114 FBXO30 0.7 16.17 0.54 1.41e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.82 -0.33 1.13e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs757110 0.770 rs1557765 chr11:17403639 T/C cg03864215 chr11:17408437 KCNJ11 -0.27 -8.09 -0.3 3.02e-15 Type 2 diabetes; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg20203395 chr5:56204925 C5orf35 -0.51 -10.2 -0.37 9.48e-23 Initial pursuit acceleration; BRCA cis rs7071206 0.947 rs716255 chr10:79419679 A/T cg00983440 chr10:79422392 NA -0.53 -10.15 -0.37 1.57e-22 Bone mineral density; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg23978390 chr7:1156363 C7orf50 0.39 7.89 0.3 1.34e-14 Bronchopulmonary dysplasia; BRCA cis rs9462027 0.606 rs2395606 chr6:34778486 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.84 -0.3 1.96e-14 Systemic lupus erythematosus; BRCA trans rs9329221 0.527 rs10903328 chr8:10332167 G/C cg06636001 chr8:8085503 FLJ10661 0.5 10.38 0.38 2.01e-23 Neuroticism; BRCA cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg21573476 chr21:45109991 RRP1B -0.49 -12.43 -0.44 6.48e-32 Mean corpuscular volume; BRCA cis rs2075371 0.932 rs2241333 chr7:133970750 C/T cg11752832 chr7:134001865 SLC35B4 0.51 13.32 0.47 6.82e-36 Mean platelet volume; BRCA cis rs9309473 0.632 rs11885217 chr2:73553208 A/G cg20560298 chr2:73613845 ALMS1 -0.43 -11.25 -0.41 6.44e-27 Metabolite levels; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg09177884 chr7:1199841 ZFAND2A -0.47 -10.17 -0.37 1.32e-22 Longevity;Endometriosis; BRCA cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7592578 0.825 rs12477369 chr2:191455624 G/T cg11845111 chr2:191398756 TMEM194B 0.76 14.08 0.49 2.15e-39 Diastolic blood pressure; BRCA cis rs9463078 0.764 rs6904015 chr6:44785502 G/A cg25276700 chr6:44698697 NA -0.36 -8.29 -0.31 6.5e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs12468557 0.527 rs12694205 chr2:211499367 A/G cg07063745 chr2:211341572 LANCL1;CPS1 -0.36 -8.05 -0.3 4.12e-15 Body mass index in asthmatics; BRCA cis rs4803468 1.000 rs2231940 chr19:41944237 T/C cg09537434 chr19:41945824 ATP5SL 1.02 24.51 0.7 4.84e-94 Height; BRCA cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.58 -0.32 7.34e-17 Glomerular filtration rate (creatinine); BRCA cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.67 0.42 1.2e-28 Hip circumference adjusted for BMI; BRCA cis rs751728 0.664 rs12196293 chr6:33749151 A/G cg25922239 chr6:33757077 LEMD2 0.51 12.87 0.45 6.89e-34 Crohn's disease; BRCA cis rs8177179 0.505 rs1405023 chr3:133481128 T/C cg01448562 chr3:133502909 NA 0.37 8.98 0.33 2.91e-18 Iron status biomarkers (transferrin levels); BRCA trans rs800082 0.501 rs10935507 chr3:144214631 A/T cg24215973 chr2:240111563 HDAC4 0.35 8.36 0.31 3.86e-16 Smoking behavior; BRCA cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.57 -0.45 1.54e-32 Bipolar disorder; BRCA cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg18132916 chr6:79620363 NA -0.45 -10.17 -0.37 1.25e-22 Intelligence (multi-trait analysis); BRCA cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg26031613 chr14:104095156 KLC1 -0.54 -9.56 -0.35 2.54e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg01483505 chr11:975446 AP2A2 0.33 9.05 0.34 1.7e-18 Alzheimer's disease (late onset); BRCA cis rs10503871 0.594 rs10954994 chr8:30306419 C/A cg26383811 chr8:30366931 RBPMS 0.3 7.98 0.3 6.6e-15 Metabolite levels (X-11787); BRCA cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg20790798 chr5:1857306 NA -0.39 -9.1 -0.34 1.12e-18 Cardiovascular disease risk factors; BRCA cis rs6977660 0.714 rs4719586 chr7:19825548 T/C cg07541023 chr7:19748670 TWISTNB 0.55 9.56 0.35 2.41e-20 Thyroid stimulating hormone; BRCA cis rs7833986 0.501 rs2719261 chr8:56941982 C/G cg26371346 chr8:56986568 SNORD54;RPS20 0.45 7.94 0.3 9.02e-15 Height; BRCA cis rs7555523 0.887 rs7518099 chr1:165736880 C/T cg24409356 chr1:165738333 TMCO1 0.51 8.37 0.31 3.65e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.79 0.42 3.64e-29 Tonsillectomy; BRCA trans rs11098499 0.909 rs1809406 chr4:120377122 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.3e-14 Corneal astigmatism; BRCA cis rs7301826 0.967 rs4759792 chr12:131296631 G/A cg11011512 chr12:131303247 STX2 0.43 10.95 0.4 1.07e-25 Plasma plasminogen activator levels; BRCA cis rs1499972 0.941 rs55864156 chr3:117664968 C/G cg07612923 chr3:117604196 NA 0.6 8.2 0.31 1.35e-15 Schizophrenia; BRCA cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg06784218 chr1:46089804 CCDC17 0.5 11.81 0.42 2.86e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg06784218 chr1:46089804 CCDC17 0.5 12.03 0.43 3.38e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs12517041 1.000 rs7737479 chr5:23288235 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.07 -0.3 3.42e-15 Calcium levels; BRCA cis rs4481887 1.000 rs4244183 chr1:248471222 G/A cg00666640 chr1:248458726 OR2T12 0.31 8.7 0.33 2.8e-17 Common traits (Other); BRCA cis rs4481887 1.000 rs7517319 chr1:248466408 C/A cg13385794 chr1:248469461 NA 0.28 7.81 0.3 2.28e-14 Common traits (Other); BRCA cis rs6842047 1.000 rs4862665 chr4:187136142 C/T cg23442198 chr4:187126114 CYP4V2 -0.55 -8.18 -0.31 1.58e-15 Blood protein levels; BRCA trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.77e-17 Extrinsic epigenetic age acceleration; BRCA cis rs9790314 0.521 rs60625846 chr3:161084525 G/T cg04691961 chr3:161091175 C3orf57 -0.46 -10.85 -0.39 2.66e-25 Morning vs. evening chronotype; BRCA cis rs4423214 0.840 rs1792229 chr11:71179395 A/G cg05163923 chr11:71159392 DHCR7 -0.56 -11.41 -0.41 1.41e-27 Vitamin D levels; BRCA cis rs12367572 0.641 rs7964973 chr12:45402893 T/C cg04608330 chr12:45269318 NELL2 -0.45 -9.96 -0.37 8.29e-22 Gut microbiome composition (summer); BRCA cis rs4481887 1.000 rs10888362 chr1:248483975 A/G cg00666640 chr1:248458726 OR2T12 -0.34 -9.36 -0.35 1.31e-19 Common traits (Other); BRCA cis rs6840360 0.571 rs4696270 chr4:152498289 G/A cg22705602 chr4:152727874 NA -0.32 -8.15 -0.31 1.93e-15 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.932 rs2563269 chr5:140136468 G/T cg16179182 chr5:140090404 VTRNA1-1 0.43 10.23 0.38 7.73e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs9986765 1.000 rs9986765 chr7:142835239 C/T cg15652212 chr7:142981776 TMEM139 -0.56 -9.43 -0.35 7.26e-20 Cancer;Dermatomyositis; BRCA cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg25767906 chr1:53392781 SCP2 0.49 10.56 0.39 4.03e-24 Monocyte count; BRCA cis rs1707322 0.896 rs785512 chr1:46534543 A/G cg03146154 chr1:46216737 IPP -0.44 -9.53 -0.35 3.21e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9470366 0.509 rs4714001 chr6:36638175 G/A cg08179530 chr6:36648295 CDKN1A -0.62 -14.56 -0.5 1.16e-41 QRS duration; BRCA cis rs877282 0.945 rs12767287 chr10:787310 A/G cg17470449 chr10:769945 NA 0.47 8.19 0.31 1.39e-15 Uric acid levels; BRCA cis rs2197308 0.765 rs11182481 chr12:37926019 T/C cg13010199 chr12:38710504 ALG10B 0.47 9.35 0.35 1.49e-19 Morning vs. evening chronotype; BRCA cis rs11098499 0.909 rs28632018 chr4:120386730 T/C cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg03709012 chr19:19516395 GATAD2A -0.75 -16.71 -0.55 2.78e-52 Tonsillectomy; BRCA cis rs1401999 0.899 rs2313211 chr3:183738626 T/A cg01324343 chr3:183735012 ABCC5 0.85 21.55 0.65 8.03e-78 Anterior chamber depth; BRCA cis rs208520 0.837 rs208471 chr6:66916749 A/C cg07460842 chr6:66804631 NA -0.89 -15.64 -0.53 6.62e-47 Exhaled nitric oxide output; BRCA cis rs2422052 1.000 rs2422052 chr2:118651764 G/C cg22545206 chr2:118617499 NA 0.45 11.25 0.41 6.64e-27 Mosquito bite size; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg14004847 chr7:1930337 MAD1L1 -0.47 -8.87 -0.33 7.53e-18 Bipolar disorder and schizophrenia; BRCA cis rs1865760 0.566 rs9295688 chr6:26084217 G/A cg16482183 chr6:26056742 HIST1H1C 0.56 11.91 0.43 1.15e-29 Height; BRCA cis rs9341808 0.754 rs1015158 chr6:80945745 C/T cg08355045 chr6:80787529 NA 0.39 9.95 0.37 8.77e-22 Sitting height ratio; BRCA cis rs6964587 1.000 rs6465343 chr7:91618208 T/C cg17063962 chr7:91808500 NA 0.57 13.55 0.47 6.1e-37 Breast cancer; BRCA trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg23505145 chr19:12996616 KLF1 0.56 12.82 0.45 1.19e-33 Prostate cancer (SNP x SNP interaction); BRCA trans rs3733585 0.699 rs6844787 chr4:9959233 A/G cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1210638 0.706 rs2518798 chr22:18970403 T/C cg06148736 chr22:18985691 NA 0.34 8.69 0.32 3.14e-17 Response to serotonin reuptake inhibitors in major depressive disorder; BRCA cis rs1190552 0.706 rs2146426 chr14:102995068 A/G cg18135206 chr14:102964638 TECPR2 0.42 7.94 0.3 8.89e-15 Blood protein levels; BRCA cis rs11098499 0.954 rs59866101 chr4:120296591 T/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg21784768 chr11:537496 LRRC56 -0.64 -8.28 -0.31 7.08e-16 Body mass index; BRCA trans rs6952808 0.594 rs3778969 chr7:2139990 A/G cg04565464 chr8:145669602 NFKBIL2 -0.42 -9.6 -0.36 1.79e-20 Bipolar disorder and schizophrenia; BRCA cis rs780094 0.585 rs3739095 chr2:27556721 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -8.0 -0.3 5.69e-15 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs7246657 0.943 rs10415358 chr19:37808863 C/A cg18154014 chr19:37997991 ZNF793 0.61 11.39 0.41 1.77e-27 Coronary artery calcification; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg26314531 chr2:26401878 FAM59B 0.96 16.57 0.55 1.37e-51 Gut microbiome composition (summer); BRCA cis rs1018836 0.923 rs4735268 chr8:91629715 C/T cg16814680 chr8:91681699 NA -0.53 -11.34 -0.41 2.83e-27 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs17401966 0.558 rs4846218 chr1:10452040 G/T cg03954927 chr1:10346856 KIF1B 0.35 10.7 0.39 1.09e-24 Hepatocellular carcinoma; BRCA cis rs9875589 0.509 rs9824910 chr3:14040136 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.87 0.33 7.42e-18 Ovarian reserve; BRCA cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg27366882 chr3:133540807 NA -0.33 -8.09 -0.3 2.92e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs35146811 0.625 rs2906645 chr7:99817859 A/G cg13334819 chr7:99746414 C7orf59 0.39 9.01 0.34 2.32e-18 Coronary artery disease; BRCA cis rs1448094 0.654 rs7133797 chr12:86294184 G/C cg19622623 chr12:86230825 RASSF9 -0.28 -7.98 -0.3 6.57e-15 Major depressive disorder; BRCA cis rs2777491 0.574 rs11858812 chr15:41731550 G/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -27.83 -0.74 3.01e-112 Ulcerative colitis; BRCA cis rs861020 0.771 rs126280 chr1:210019824 A/G cg09163369 chr1:210001066 C1orf107 0.53 10.86 0.39 2.44e-25 Orofacial clefts; BRCA cis rs6121246 0.697 rs6087716 chr20:30229040 C/T cg21427119 chr20:30132790 HM13 -0.43 -9.03 -0.34 2e-18 Mean corpuscular hemoglobin; BRCA cis rs4803468 1.000 rs11883104 chr19:41923799 T/C cg09537434 chr19:41945824 ATP5SL -1.0 -23.91 -0.69 9.81e-91 Height; BRCA cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg17143192 chr8:8559678 CLDN23 0.55 10.58 0.39 3.37e-24 Obesity-related traits; BRCA cis rs7561273 0.609 rs3795953 chr2:24345707 C/G cg04809136 chr2:24300158 SF3B14 -0.4 -8.94 -0.33 4.13e-18 Quantitative traits; BRCA cis rs6964587 0.839 rs6950538 chr7:91417816 T/C cg17063962 chr7:91808500 NA 0.5 11.16 0.4 1.52e-26 Breast cancer; BRCA cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg03146154 chr1:46216737 IPP 0.54 11.96 0.43 6.78e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs858239 0.867 rs10250602 chr7:23303701 T/C cg23682824 chr7:23144976 KLHL7 0.35 8.79 0.33 1.41e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs6674970 1.000 rs6674970 chr1:151116279 C/T cg11822372 chr1:151115635 SEMA6C 0.55 10.81 0.39 3.81e-25 Childhood ear infection; BRCA cis rs17253792 0.822 rs8009608 chr14:56062590 C/T cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs34779708 0.931 rs4934719 chr10:35376769 T/C cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.34 -0.35 1.6e-19 Alzheimer's disease (late onset); BRCA cis rs2011503 1.000 rs2905422 chr19:19460703 A/G cg11584989 chr19:19387371 SF4 -0.66 -13.23 -0.46 1.77e-35 Bipolar disorder; BRCA cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg08000102 chr2:233561755 GIGYF2 -0.63 -13.56 -0.47 5.55e-37 Coronary artery disease; BRCA cis rs5758659 0.519 rs133307 chr22:42396568 C/A cg15557168 chr22:42548783 NA -0.32 -8.81 -0.33 1.18e-17 Cognitive function; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.21 -0.54 9.83e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6570726 0.526 rs9403699 chr6:145730685 G/T cg23711669 chr6:146136114 FBXO30 0.46 9.92 0.37 1.14e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs73607871 chr8:58173007 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg04944784 chr2:26401820 FAM59B 0.99 16.67 0.55 4.32e-52 Gut microbiome composition (summer); BRCA cis rs172166 0.694 rs1770131 chr6:28086413 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.02 0.3 5.21e-15 Cardiac Troponin-T levels; BRCA cis rs7572733 0.534 rs700680 chr2:198707950 A/T cg00792783 chr2:198669748 PLCL1 -0.47 -10.25 -0.38 6.04e-23 Dermatomyositis; BRCA cis rs4076764 0.958 rs10917748 chr1:163400377 T/C cg24596788 chr1:163392923 NA -0.4 -10.68 -0.39 1.28e-24 Motion sickness; BRCA cis rs372883 0.648 rs368322 chr21:30717151 C/T cg24692254 chr21:30365293 RNF160 -0.47 -10.64 -0.39 1.83e-24 Pancreatic cancer; BRCA trans rs17685 0.515 rs111240556 chr7:75600863 T/C cg19862616 chr7:65841803 NCRNA00174 0.36 8.64 0.32 4.57e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11249608 0.548 rs13161528 chr5:178452958 C/G cg21905437 chr5:178450457 ZNF879 0.51 10.72 0.39 8.79e-25 Pubertal anthropometrics; BRCA cis rs6430585 0.528 rs309154 chr2:136726567 C/T cg07169764 chr2:136633963 MCM6 1.02 19.09 0.6 1.32e-64 Corneal structure; BRCA cis rs1577917 1.000 rs68171315 chr6:86707400 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -13.27 -0.46 1.09e-35 Response to antipsychotic treatment; BRCA cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg08219700 chr8:58056026 NA 0.45 8.18 0.31 1.52e-15 Developmental language disorder (linguistic errors); BRCA cis rs7267979 0.706 rs6037069 chr20:25234166 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.04 0.3 4.32e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6570726 1.000 rs450076 chr6:145847655 G/T cg23711669 chr6:146136114 FBXO30 0.64 14.88 0.51 3.31e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg07308232 chr7:1071921 C7orf50 -0.44 -9.28 -0.34 2.62e-19 Longevity;Endometriosis; BRCA cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg06484146 chr7:12443880 VWDE -0.71 -10.81 -0.39 4.05e-25 Coronary artery disease; BRCA cis rs4363385 0.720 rs1415968 chr1:152970219 C/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.42 -0.35 8.42e-20 Inflammatory skin disease; BRCA cis rs7633857 0.537 rs9813700 chr3:160683279 G/T cg03342759 chr3:160939853 NMD3 -0.45 -9.21 -0.34 4.77e-19 Educational attainment (years of education); BRCA cis rs921968 0.565 rs6436072 chr2:219598095 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -11.0 -0.4 6.73e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg24130564 chr14:104152367 KLC1 0.36 8.15 0.31 1.91e-15 Intelligence (multi-trait analysis); BRCA cis rs3772130 0.962 rs11706783 chr3:121534322 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.91 0.4 1.63e-25 Cognitive performance; BRCA trans rs8073060 0.586 rs188959 chr17:34021307 C/A cg19694781 chr19:47549865 TMEM160 -1.07 -21.69 -0.65 1.28e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs11098499 0.863 rs1010739 chr4:120463471 C/T cg09307838 chr4:120376055 NA 0.72 14.24 0.49 3.81e-40 Corneal astigmatism; BRCA cis rs10267417 0.603 rs12333603 chr7:19907821 C/G cg05791153 chr7:19748676 TWISTNB -0.47 -9.28 -0.34 2.65e-19 Night sleep phenotypes; BRCA cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg26031613 chr14:104095156 KLC1 0.43 8.51 0.32 1.22e-16 Schizophrenia; BRCA cis rs2153535 0.580 rs4960433 chr6:8523697 A/G cg23788917 chr6:8435910 SLC35B3 0.47 10.25 0.38 6.41e-23 Motion sickness; BRCA cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg22974920 chr21:40686053 BRWD1 -0.36 -8.02 -0.3 5.17e-15 Menarche (age at onset); BRCA cis rs9341808 0.754 rs9341811 chr6:80982701 G/A cg08355045 chr6:80787529 NA 0.36 9.19 0.34 5.48e-19 Sitting height ratio; BRCA cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg21475434 chr5:93447410 FAM172A 0.66 8.42 0.32 2.47e-16 Diabetic retinopathy; BRCA trans rs1997103 1.000 rs6949244 chr7:55411301 C/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7903847 0.619 rs10882912 chr10:99138077 C/T cg08345082 chr10:99160200 RRP12 -0.29 -8.51 -0.32 1.24e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs1801251 0.963 rs7562712 chr2:233606580 A/G cg08000102 chr2:233561755 GIGYF2 0.64 13.95 0.48 8.76e-39 Coronary artery disease; BRCA cis rs1215050 0.791 rs165252 chr4:98758728 A/C cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs360798 0.553 rs11682530 chr2:63073194 C/T cg17519650 chr2:63277830 OTX1 -0.39 -8.6 -0.32 6.04e-17 Coronary artery disease; BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.45 -9.0 -0.34 2.49e-18 Tonsillectomy; BRCA trans rs8073060 0.533 rs178736 chr17:33928158 G/T cg19694781 chr19:47549865 TMEM160 -1.05 -21.6 -0.65 4.24e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs61931739 0.817 rs11053071 chr12:34201400 A/G cg26384229 chr12:38710491 ALG10B 0.42 10.18 0.37 1.19e-22 Morning vs. evening chronotype; BRCA cis rs5167 0.504 rs3760627 chr19:45457180 T/C cg13119609 chr19:45449297 APOC2 0.47 12.99 0.46 2.17e-34 Blood protein levels; BRCA cis rs9287719 0.967 rs6432122 chr2:10753844 A/G cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.19 -0.31 1.42e-15 Total body bone mineral density; BRCA cis rs7809950 0.906 rs2253269 chr7:107201114 C/T cg23024343 chr7:107201750 COG5 -0.38 -8.88 -0.33 6.83e-18 Coronary artery disease; BRCA cis rs9467773 0.583 rs1021373 chr6:26632457 G/A cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.68e-30 Intelligence (multi-trait analysis); BRCA trans rs1005277 0.565 rs2474565 chr10:38380828 A/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.77 -0.48 5.65e-38 Extrinsic epigenetic age acceleration; BRCA cis rs739401 0.572 rs384490 chr11:3078885 A/C cg05729581 chr11:3078854 CARS -0.37 -9.08 -0.34 1.3e-18 Longevity; BRCA cis rs6495122 0.501 rs12101482 chr15:75344784 A/T cg13906792 chr15:75199810 C15orf17 0.34 8.07 0.3 3.59e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; BRCA cis rs1044826 0.518 rs295488 chr3:139239323 C/T cg00490450 chr3:139108681 COPB2 0.51 9.92 0.37 1.17e-21 Obesity-related traits; BRCA cis rs2180341 1.000 rs2038378 chr6:127590400 C/T cg27446573 chr6:127587934 RNF146 0.89 20.41 0.63 1.17e-71 Breast cancer; BRCA cis rs495337 0.736 rs6020073 chr20:48448280 A/G cg17835207 chr20:48524531 SPATA2 0.49 10.66 0.39 1.5e-24 Psoriasis; BRCA cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 26.4 0.72 1.95e-104 Chronic sinus infection; BRCA cis rs4911253 0.527 rs853859 chr20:31402269 A/G cg13636640 chr20:31349939 DNMT3B 0.46 10.78 0.39 5.11e-25 Lymphocyte counts; BRCA cis rs763121 0.853 rs5750630 chr22:38985818 A/C cg14440974 chr22:39074834 NA -0.4 -9.17 -0.34 6.33e-19 Menopause (age at onset); BRCA cis rs10929956 0.760 rs2729704 chr2:160707866 T/A cg14819504 chr2:160761413 LY75 -0.34 -8.43 -0.32 2.26e-16 Crohn's disease-related phenotypes; BRCA cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg01256987 chr12:42539512 GXYLT1 -0.69 -16.56 -0.55 1.6e-51 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7103648 0.966 rs1377416 chr11:47416746 C/T cg20307385 chr11:47447363 PSMC3 0.85 25.32 0.71 1.69e-98 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9463078 0.715 rs1557143 chr6:44756415 T/C cg25276700 chr6:44698697 NA 0.39 8.92 0.33 5.02e-18 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs10242455 0.702 rs7794068 chr7:99146873 A/T cg18809830 chr7:99032528 PTCD1 -0.58 -8.58 -0.32 7.15e-17 Blood metabolite levels; BRCA cis rs7020830 0.861 rs13289001 chr9:37311592 A/G cg14294708 chr9:37120828 ZCCHC7 1.17 41.38 0.85 6.41e-183 Schizophrenia; BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.26 -0.49 3e-40 Platelet count; BRCA trans rs9291683 0.609 rs13149985 chr4:10028390 G/A cg26043149 chr18:55253948 FECH 0.42 9.09 0.34 1.22e-18 Bone mineral density; BRCA cis rs826838 0.872 rs826878 chr12:39088837 A/T cg26384229 chr12:38710491 ALG10B -0.58 -14.82 -0.51 6.12e-43 Heart rate; BRCA cis rs1401999 0.606 rs7644687 chr3:183753353 A/G cg01324343 chr3:183735012 ABCC5 0.8 17.69 0.57 2.57e-57 Anterior chamber depth; BRCA cis rs4727027 0.835 rs11767810 chr7:148774433 T/A cg23583168 chr7:148888333 NA -0.82 -18.75 -0.6 8.07e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs6582630 0.537 rs1949610 chr12:38387838 C/T cg06521331 chr12:34319734 NA -0.46 -8.5 -0.32 1.34e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs11105298 0.891 rs10777162 chr12:89830523 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.54 -9.18 -0.34 5.74e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9790314 0.846 rs4470535 chr3:160974468 G/A cg03342759 chr3:160939853 NMD3 -0.67 -15.69 -0.53 3.5e-47 Morning vs. evening chronotype; BRCA cis rs72781680 1.000 rs7578969 chr2:24168620 T/C cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs698833 0.886 rs6721675 chr2:44566027 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.47 0.38 9.14e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.49 9.28 0.34 2.65e-19 Tonsillectomy; BRCA cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg03354898 chr7:1950403 MAD1L1 -0.49 -10.65 -0.39 1.65e-24 Bipolar disorder and schizophrenia; BRCA cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.4 8.71 0.33 2.68e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.82 0.73 9.73e-107 Chronic sinus infection; BRCA trans rs208515 0.518 rs12209790 chr6:66662965 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 15.87 0.53 4.53e-48 Exhaled nitric oxide levels; BRCA cis rs7833986 0.501 rs72651502 chr8:56875533 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.32 0.44 2e-31 Height; BRCA cis rs9287719 0.967 rs6719701 chr2:10748283 G/A cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs9814567 1.000 rs4368544 chr3:134300014 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.76 0.62 3.56e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9858542 0.953 rs7622302 chr3:49547561 T/C cg03060546 chr3:49711283 APEH -0.51 -10.06 -0.37 3.4e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2180341 0.804 rs6902233 chr6:127555963 A/G cg27446573 chr6:127587934 RNF146 0.81 15.69 0.53 3.75e-47 Breast cancer; BRCA cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg12365402 chr11:9010492 NRIP3 -0.37 -8.43 -0.32 2.23e-16 Hemoglobin concentration; BRCA cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg05347473 chr6:146136440 FBXO30 0.41 8.01 0.3 5.36e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs28595532 1.000 rs41455648 chr4:119718030 A/G cg21605333 chr4:119757512 SEC24D 1.31 12.88 0.45 6.22e-34 Cannabis dependence symptom count; BRCA cis rs7264396 0.635 rs6060703 chr20:34529906 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.94 -0.51 1.6e-43 Total cholesterol levels; BRCA cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg03146154 chr1:46216737 IPP 0.44 9.95 0.37 8.9e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7715811 0.913 rs1910091 chr5:13781535 G/A cg07548982 chr5:13769939 DNAH5 -0.4 -8.82 -0.33 1.08e-17 Subclinical atherosclerosis traits (other); BRCA cis rs637571 0.522 rs493899 chr11:65747952 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 10.11 0.37 2.24e-22 Eosinophil percentage of white cells; BRCA cis rs7552404 0.807 rs2066183 chr1:76153745 A/G cg10523679 chr1:76189770 ACADM 0.88 20.66 0.63 5.02e-73 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11690935 0.959 rs10497374 chr2:172640623 A/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -30.07 -0.77 1.89e-124 Schizophrenia; BRCA cis rs11758351 1.000 rs16891401 chr6:26202337 G/A cg01420254 chr6:26195488 NA 0.57 8.89 0.33 6e-18 Gout;Renal underexcretion gout; BRCA cis rs250677 0.652 rs250680 chr5:148436024 T/C cg12140854 chr5:148520817 ABLIM3 -0.43 -9.19 -0.34 5.38e-19 Breast cancer; BRCA cis rs7258465 0.965 rs7254249 chr19:18591745 G/A cg01065977 chr19:18549689 ISYNA1 -0.28 -8.43 -0.32 2.33e-16 Breast cancer; BRCA cis rs311392 0.902 rs1511147 chr8:55091227 C/T cg11783602 chr8:55087084 NA -0.32 -9.43 -0.35 7.39e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg05347473 chr6:146136440 FBXO30 -0.6 -11.51 -0.41 5.38e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg07308232 chr7:1071921 C7orf50 -0.43 -8.85 -0.33 8.21e-18 Longevity;Endometriosis; BRCA cis rs6430585 0.528 rs309120 chr2:136708787 G/C cg07169764 chr2:136633963 MCM6 1.01 21.03 0.64 5.41e-75 Corneal structure; BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg22800045 chr5:56110881 MAP3K1 0.64 12.19 0.43 6.84e-31 Initial pursuit acceleration; BRCA cis rs8016982 0.662 rs1951616 chr14:81671752 T/C cg01989461 chr14:81687754 GTF2A1 0.47 8.5 0.32 1.34e-16 Schizophrenia; BRCA cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg01448562 chr3:133502909 NA -0.64 -15.18 -0.51 1.09e-44 Iron status biomarkers; BRCA cis rs7772486 0.790 rs9497425 chr6:146234197 G/A cg23711669 chr6:146136114 FBXO30 -0.67 -15.72 -0.53 2.69e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs1611760 chr1:152957573 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.79 -0.33 1.42e-17 Inflammatory skin disease; BRCA cis rs11229555 0.645 rs4594017 chr11:58194788 T/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg08132940 chr7:1081526 C7orf50 -0.46 -8.29 -0.31 6.84e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72781680 0.898 rs12623316 chr2:24087857 A/G cg08917208 chr2:24149416 ATAD2B 0.91 13.42 0.47 2.48e-36 Lymphocyte counts; BRCA cis rs2243480 1.000 rs34136756 chr7:65381256 A/G cg18252515 chr7:66147081 NA -0.83 -12.01 -0.43 4.26e-30 Diabetic kidney disease; BRCA cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.43 0.5 4.82e-41 Personality dimensions; BRCA cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg14664628 chr15:75095509 CSK -0.53 -12.48 -0.44 3.67e-32 Breast cancer; BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00166722 chr3:10149974 C3orf24 0.65 12.98 0.46 2.38e-34 Alzheimer's disease; BRCA cis rs3858526 0.523 rs10769290 chr11:5886947 T/A cg13902645 chr11:5959945 NA -0.47 -10.42 -0.38 1.42e-23 DNA methylation (variation); BRCA cis rs922182 0.617 rs11852732 chr15:64239907 G/A cg24729988 chr15:64271149 DAPK2 0.49 10.74 0.39 7.31e-25 Blood protein levels; BRCA cis rs11758351 1.000 rs16891397 chr6:26200256 C/T cg01420254 chr6:26195488 NA 0.56 8.72 0.33 2.43e-17 Gout;Renal underexcretion gout; BRCA cis rs9325144 0.510 rs6582599 chr12:38715965 T/G cg26384229 chr12:38710491 ALG10B 0.51 12.78 0.45 1.76e-33 Morning vs. evening chronotype; BRCA cis rs11888559 0.655 rs4675309 chr2:203879503 A/G cg24605529 chr2:203879461 NBEAL1 0.45 8.53 0.32 1.05e-16 Height; BRCA cis rs13161895 1.000 rs34882290 chr5:179463836 C/A cg02702477 chr5:179499311 RNF130 0.46 8.51 0.32 1.24e-16 LDL cholesterol; BRCA cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg24675658 chr1:53192096 ZYG11B -0.53 -11.41 -0.41 1.38e-27 Monocyte count; BRCA cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 2.97e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg21573476 chr21:45109991 RRP1B 0.35 9.25 0.34 3.21e-19 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg08888203 chr3:10149979 C3orf24 0.61 13.19 0.46 2.57e-35 Alzheimer's disease; BRCA cis rs1499614 1.000 rs2141924 chr7:66186246 C/T cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.75e-16 Menopause (age at onset); BRCA cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg05623727 chr3:50126028 RBM5 0.48 11.24 0.41 6.93e-27 Body mass index; BRCA cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg00290607 chr11:67383545 NA -0.51 -10.92 -0.4 1.41e-25 Mean corpuscular volume; BRCA cis rs8180040 0.967 rs4858890 chr3:47405456 A/G cg16586182 chr3:47516702 SCAP 0.59 13.26 0.46 1.32e-35 Colorectal cancer; BRCA cis rs2230307 0.656 rs11166389 chr1:100466279 G/A cg24955406 chr1:100503596 HIAT1 0.54 9.42 0.35 8.29e-20 Carotid intima media thickness; BRCA cis rs34779708 0.966 rs35814343 chr10:35427714 G/T cg03585969 chr10:35415529 CREM 0.56 11.44 0.41 1.04e-27 Inflammatory bowel disease;Crohn's disease; BRCA trans rs11039798 0.588 rs12278284 chr11:48612063 G/C cg03929089 chr4:120376271 NA 0.47 7.92 0.3 1.09e-14 Axial length; BRCA cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg13010199 chr12:38710504 ALG10B 0.52 11.02 0.4 5.69e-26 Heart rate; BRCA cis rs7568458 0.660 rs6722691 chr2:85758352 C/T cg02493740 chr2:85810744 VAMP5 -0.51 -10.55 -0.39 4.25e-24 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs778371 1.000 rs778370 chr2:233743363 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -17.24 -0.56 5.72e-55 Schizophrenia; BRCA cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg11062466 chr8:58055876 NA 0.42 7.92 0.3 1.02e-14 Developmental language disorder (linguistic errors); BRCA cis rs4742903 0.967 rs10512325 chr9:106861191 C/T cg14250997 chr9:106856677 SMC2 0.34 10.67 0.39 1.48e-24 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs8072100 0.934 rs8067286 chr17:45594590 A/G cg08085267 chr17:45401833 C17orf57 0.67 15.02 0.51 7.02e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg15556689 chr8:8085844 FLJ10661 0.4 10.45 0.38 1.07e-23 Neuroticism; BRCA cis rs72772090 0.522 rs17399215 chr5:96016280 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -8.12 -0.31 2.41e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1348850 0.526 rs10497504 chr2:178370040 T/C cg27490568 chr2:178487706 NA 0.51 8.58 0.32 7.29e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2070488 1.000 rs3792527 chr3:38493212 T/C cg24069376 chr3:38537580 EXOG 0.41 11.94 0.43 8.01e-30 Electrocardiographic conduction measures; BRCA cis rs870825 0.616 rs6852082 chr4:185645783 T/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs9486719 1.000 rs12205655 chr6:96891733 T/A cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA trans rs7615952 0.932 rs9841157 chr3:125635655 C/A cg07211511 chr3:129823064 LOC729375 -1.05 -18.4 -0.59 5.22e-61 Blood pressure (smoking interaction); BRCA cis rs6542838 0.588 rs4851175 chr2:99530118 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -9.62 -0.36 1.56e-20 Fear of minor pain; BRCA cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg08754478 chr10:133766260 PPP2R2D -0.67 -13.78 -0.48 5.21e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12458462 0.812 rs34583578 chr18:77491070 C/T cg11879182 chr18:77439856 CTDP1 0.63 13.12 0.46 5.44e-35 Monocyte count; BRCA cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.38 0.35 1.14e-19 Tonsillectomy; BRCA cis rs17685 0.725 rs7795291 chr7:75725206 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.53 -0.35 3.16e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4862750 0.914 rs6553026 chr4:187875648 C/T cg22105103 chr4:187893119 NA 0.38 11.91 0.43 1.11e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.644 rs72783627 chr2:24315685 A/C cg06627628 chr2:24431161 ITSN2 -0.51 -8.28 -0.31 7.01e-16 Lymphocyte counts; BRCA cis rs3749237 0.964 rs1799843 chr3:49849723 G/A cg07636037 chr3:49044803 WDR6 0.4 8.15 0.31 1.98e-15 Resting heart rate; BRCA cis rs7246657 0.943 rs4803229 chr19:37864682 T/G cg14683738 chr19:37701593 ZNF585B 0.45 8.05 0.3 3.98e-15 Coronary artery calcification; BRCA cis rs208520 0.690 rs207114 chr6:66791703 C/T cg07460842 chr6:66804631 NA -1.02 -19.91 -0.62 5.24e-69 Exhaled nitric oxide output; BRCA cis rs2882667 0.690 rs13178601 chr5:138267377 G/A cg04439458 chr5:138467593 SIL1 -0.31 -7.82 -0.3 2.21e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7818345 1.000 rs6984145 chr8:19294111 A/G cg11303988 chr8:19266685 CSGALNACT1 0.31 7.94 0.3 8.95e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs9837602 0.576 rs506186 chr3:99442753 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -9.57 -0.35 2.39e-20 Breast cancer; BRCA cis rs6089584 0.927 rs11697597 chr20:60584748 C/T cg13770153 chr20:60521292 NA -0.45 -10.57 -0.39 3.7e-24 Body mass index; BRCA cis rs11098499 0.644 rs10009566 chr4:120558608 A/G cg09307838 chr4:120376055 NA 0.59 12.31 0.44 2.18e-31 Corneal astigmatism; BRCA cis rs6840360 0.554 rs4643789 chr4:152726691 C/T cg22705602 chr4:152727874 NA -0.37 -10.25 -0.38 6.35e-23 Intelligence (multi-trait analysis); BRCA trans rs2840044 1.000 rs225304 chr17:33921857 G/T cg19694781 chr19:47549865 TMEM160 -0.45 -10.51 -0.38 6.2e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs17401966 0.558 rs12128374 chr1:10426417 G/A cg03954927 chr1:10346856 KIF1B 0.34 10.19 0.37 1.12e-22 Hepatocellular carcinoma; BRCA cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.07 0.46 9.57e-35 Bipolar disorder; BRCA cis rs4787491 0.729 rs4788212 chr16:30034469 G/T cg06326092 chr16:30034487 C16orf92 -0.38 -9.71 -0.36 6.87e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs992157 0.764 rs10932774 chr2:219191569 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.47 9.55 0.35 2.75e-20 Colorectal cancer; BRCA cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg24296786 chr1:45957014 TESK2 0.59 14.42 0.5 5.24e-41 High light scatter reticulocyte count; BRCA cis rs7020830 0.867 rs1472169 chr9:37209396 C/T cg14294708 chr9:37120828 ZCCHC7 1.14 37.66 0.83 2.28e-164 Schizophrenia; BRCA cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg08885076 chr2:99613938 TSGA10 0.43 10.07 0.37 3.12e-22 Chronic sinus infection; BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg14863265 chr7:2801509 GNA12 -0.45 -9.96 -0.37 8.01e-22 Height; BRCA cis rs7246657 1.000 rs8110011 chr19:37745813 G/T cg23950597 chr19:37808831 NA -0.65 -11.1 -0.4 2.75e-26 Coronary artery calcification; BRCA cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg09035930 chr12:129282057 SLC15A4 0.58 17.23 0.56 6.42e-55 Systemic lupus erythematosus; BRCA cis rs12497850 0.864 rs3212 chr3:49145741 T/C cg06212747 chr3:49208901 KLHDC8B 0.5 10.34 0.38 2.91e-23 Parkinson's disease; BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg03609598 chr5:56110824 MAP3K1 -0.47 -8.33 -0.31 4.97e-16 Initial pursuit acceleration; BRCA cis rs367943 1.000 rs168366 chr5:112818587 C/T cg12552261 chr5:112820674 MCC 0.55 12.13 0.43 1.31e-30 Type 2 diabetes; BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg00106254 chr7:1943704 MAD1L1 -0.41 -11.15 -0.4 1.65e-26 Bipolar disorder and schizophrenia; BRCA trans rs2204008 0.774 rs8186954 chr12:38318566 C/A cg06521331 chr12:34319734 NA -0.46 -8.56 -0.32 8.34e-17 Bladder cancer; BRCA cis rs495337 0.766 rs6122835 chr20:48452498 T/C cg17835207 chr20:48524531 SPATA2 0.5 10.92 0.4 1.46e-25 Psoriasis; BRCA cis rs2637030 0.542 rs429384 chr5:52908205 A/G cg06476337 chr5:52856530 NDUFS4 0.38 8.76 0.33 1.76e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs727479 0.502 rs4774583 chr15:51505993 A/G cg19946085 chr15:51559439 CYP19A1 -0.3 -8.29 -0.31 6.62e-16 Estradiol levels; BRCA trans rs453301 0.658 rs3855900 chr8:8901921 A/G cg21775007 chr8:11205619 TDH -0.39 -8.23 -0.31 1.08e-15 Joint mobility (Beighton score); BRCA cis rs11792861 0.591 rs7027874 chr9:111717112 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 13.06 0.46 9.8e-35 Menarche (age at onset); BRCA cis rs2797160 1.000 rs78602343 chr6:126019768 T/C cg05901451 chr6:126070800 HEY2 0.4 9.77 0.36 4.03e-21 Endometrial cancer; BRCA cis rs2115536 0.730 rs4238512 chr15:80183898 A/C cg02196730 chr15:80188777 MTHFS -0.36 -8.21 -0.31 1.23e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg17971929 chr21:40555470 PSMG1 0.8 18.58 0.59 6.1e-62 Cognitive function; BRCA cis rs10208940 0.843 rs7608248 chr2:68851403 C/T cg12452813 chr2:68675892 NA 0.49 8.81 0.33 1.16e-17 Urate levels in lean individuals; BRCA cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs7246657 0.722 rs2927742 chr19:38133618 T/C cg23950597 chr19:37808831 NA 0.52 8.87 0.33 7.37e-18 Coronary artery calcification; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg26608667 chr7:1196370 ZFAND2A 0.43 10.18 0.37 1.22e-22 Longevity;Endometriosis; BRCA cis rs1784581 1.000 rs1784581 chr6:162401127 A/C cg17173639 chr6:162384350 PARK2 -0.44 -10.32 -0.38 3.29e-23 Itch intensity from mosquito bite; BRCA cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg20503657 chr10:835505 NA 1.09 18.0 0.58 6.98e-59 Eosinophil percentage of granulocytes; BRCA trans rs8073060 0.586 rs6505486 chr17:33996776 G/A cg19694781 chr19:47549865 TMEM160 -1.05 -21.57 -0.65 6.35e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.74 -16.42 -0.54 7.87e-51 Lymphocyte counts; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.73 16.28 0.54 4.04e-50 Lymphocyte counts; BRCA trans rs4714291 0.963 rs761801 chr6:39997176 G/A cg02267698 chr19:7991119 CTXN1 0.4 7.94 0.3 8.84e-15 Strep throat; BRCA cis rs9297145 0.761 rs12534399 chr7:98746401 A/G cg05967295 chr7:98741636 SMURF1 0.94 17.18 0.56 1.18e-54 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs9868809 0.881 rs3821876 chr3:48668394 G/T cg00383909 chr3:49044727 WDR6 0.55 8.31 0.31 5.79e-16 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs8114671 0.967 rs6088734 chr20:33745046 A/T cg24642439 chr20:33292090 TP53INP2 0.42 8.32 0.31 5.35e-16 Height; BRCA cis rs2859741 0.528 rs2359647 chr1:37483054 A/T cg09363841 chr1:37513479 NA -0.51 -10.91 -0.4 1.61e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs7927592 0.956 rs6591341 chr11:68335478 C/T cg20283391 chr11:68216788 NA -0.39 -8.1 -0.31 2.74e-15 Total body bone mineral density; BRCA trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg03929089 chr4:120376271 NA 0.65 12.64 0.45 7.38e-33 Coronary artery disease; BRCA cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.21 0.49 5.12e-40 Personality dimensions; BRCA cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg21132104 chr15:45694354 SPATA5L1 0.75 16.95 0.56 1.66e-53 Homoarginine levels; BRCA cis rs10046574 0.731 rs10458299 chr7:135052348 C/T cg27474649 chr7:135195673 CNOT4 0.59 7.9 0.3 1.19e-14 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs61931739 0.500 rs34080094 chr12:34547952 G/A cg06521331 chr12:34319734 NA -0.56 -10.15 -0.37 1.52e-22 Morning vs. evening chronotype; BRCA cis rs6570726 0.791 rs387376 chr6:145822565 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg26314531 chr2:26401878 FAM59B -0.62 -10.94 -0.4 1.16e-25 Gut microbiome composition (summer); BRCA cis rs992157 0.798 rs4674284 chr2:219161241 C/T cg00012203 chr2:219082015 ARPC2 -0.47 -8.98 -0.33 2.9e-18 Colorectal cancer; BRCA cis rs514406 0.729 rs534070 chr1:53308858 T/G cg01802117 chr1:53393560 SCP2 -0.4 -9.01 -0.34 2.28e-18 Monocyte count; BRCA cis rs6005807 0.668 rs60065194 chr22:28993756 A/G cg12565055 chr22:29076175 TTC28 0.5 9.38 0.35 1.17e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs2404602 0.967 rs7174096 chr15:77072400 A/G cg26408565 chr15:76604113 ETFA -0.36 -7.89 -0.3 1.28e-14 Blood metabolite levels; BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.74 0.33 2e-17 Tonsillectomy; BRCA cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.34 7.81 0.3 2.31e-14 Tonsillectomy; BRCA cis rs7766436 0.885 rs765782 chr6:22592216 A/G cg13666174 chr6:22585274 NA -0.48 -11.44 -0.41 1.03e-27 Coronary artery disease; BRCA cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg13628971 chr7:2884303 GNA12 0.6 13.53 0.47 7.58e-37 Height; BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg03354898 chr7:1950403 MAD1L1 -0.47 -9.46 -0.35 5.89e-20 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg02556042 chr12:117471086 NA 0.58 10.13 0.37 1.85e-22 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 9.06e-16 Height; BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.33e-19 Tonsillectomy; BRCA cis rs2276314 1.000 rs4799835 chr18:33571268 G/A cg05985134 chr18:33552581 C18orf21 0.69 12.55 0.44 1.92e-32 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg03188948 chr7:1209495 NA 0.55 10.18 0.37 1.19e-22 Longevity;Endometriosis; BRCA cis rs2014572 0.967 rs11667407 chr19:57763122 C/T cg24459738 chr19:57751996 ZNF805 -0.37 -8.71 -0.33 2.59e-17 Hyperactive-impulsive symptoms; BRCA cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg27366882 chr3:133540807 NA -0.32 -7.99 -0.3 6.48e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs28735056 0.933 rs499260 chr18:77589689 G/A cg20368463 chr18:77673604 PQLC1 -0.34 -8.08 -0.3 3.36e-15 Schizophrenia; BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.2 -0.43 6.44e-31 Alzheimer's disease; BRCA cis rs782590 0.935 rs2586954 chr2:55892261 A/C cg18811423 chr2:55921094 PNPT1 0.76 25.28 0.71 2.82e-98 Metabolic syndrome; BRCA cis rs2505998 0.912 rs2505994 chr10:43568887 C/T cg15436174 chr10:43711423 RASGEF1A 0.41 7.82 0.3 2.25e-14 Hirschsprung disease; BRCA cis rs8005677 1.000 rs4982712 chr14:23403728 A/G cg01529538 chr14:23388837 RBM23 0.41 11.08 0.4 3.13e-26 Cognitive ability (multi-trait analysis); BRCA cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg01689657 chr7:91764605 CYP51A1 0.22 7.92 0.3 1.09e-14 Breast cancer; BRCA cis rs1691799 0.899 rs1168358 chr12:66748664 A/G cg16791601 chr12:66731901 HELB -0.62 -16.39 -0.54 1.16e-50 White blood cell count (basophil); BRCA cis rs7599312 0.534 rs2128321 chr2:213405276 G/T cg16329650 chr2:213403929 ERBB4 0.67 19.46 0.61 1.4e-66 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17685 0.753 rs7804598 chr7:75702578 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.43 -9.66 -0.36 1.03e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9788721 0.836 rs17484524 chr15:78772676 A/G cg18825076 chr15:78729989 IREB2 -0.45 -8.75 -0.33 1.87e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.0 -12.4 -0.44 8.88e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs752010 0.631 rs1073197 chr1:42059822 C/T cg06885757 chr1:42089581 HIVEP3 -0.4 -13.09 -0.46 7.3e-35 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs12479064 0.724 rs28369945 chr2:100080928 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.5 -9.4 -0.35 9.23e-20 Chronic sinus infection; BRCA cis rs11098499 0.779 rs10011097 chr4:120310359 T/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.68 12.0 0.43 4.77e-30 Lung cancer in ever smokers; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.83 -13.87 -0.48 1.98e-38 Platelet count; BRCA cis rs7756236 0.538 rs6936598 chr6:36626096 T/C cg08179530 chr6:36648295 CDKN1A 0.37 7.9 0.3 1.24e-14 QRS duration; BRCA cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -20.03 -0.62 1.28e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg08754478 chr10:133766260 PPP2R2D -0.69 -14.21 -0.49 5.13e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs3849570 0.925 rs13091492 chr3:81891476 A/G cg07356753 chr3:81810745 GBE1 -0.41 -9.96 -0.37 7.99e-22 Waist circumference;Body mass index; BRCA cis rs910316 0.967 rs119076 chr14:75572419 G/T cg11812906 chr14:75593930 NEK9 -0.62 -14.38 -0.49 8.19e-41 Height; BRCA cis rs6745190 0.575 rs7569991 chr2:181975252 T/G cg00481216 chr2:181971175 NA 0.4 9.45 0.35 6.15e-20 White blood cell count; BRCA cis rs9811920 0.809 rs1384062 chr3:99597928 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.57 13.87 0.48 1.9e-38 Axial length; BRCA cis rs735396 1.000 rs735396 chr12:121438844 T/C cg02403541 chr12:121454288 C12orf43 0.53 9.96 0.37 7.72e-22 N-glycan levels; BRCA cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg11941060 chr3:133502564 NA -0.51 -12.3 -0.44 2.31e-31 Iron status biomarkers; BRCA cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg03934865 chr2:198174659 NA -0.37 -8.16 -0.31 1.78e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7605378 0.528 rs281787 chr2:200784238 C/T cg17644776 chr2:200775616 C2orf69 -0.45 -9.38 -0.35 1.17e-19 Osteoporosis; BRCA cis rs4332037 0.851 rs10268609 chr7:1962163 A/C cg23422044 chr7:1970798 MAD1L1 -0.55 -10.37 -0.38 2.21e-23 Bipolar disorder; BRCA cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg11764359 chr7:65958608 NA 0.74 16.3 0.54 3.24e-50 Aortic root size; BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg03709012 chr19:19516395 GATAD2A 0.81 18.96 0.6 6.13e-64 Tonsillectomy; BRCA cis rs793571 0.544 rs11638244 chr15:58907151 A/T cg05156742 chr15:59063176 FAM63B 0.48 9.71 0.36 6.74e-21 Schizophrenia; BRCA cis rs2996428 0.667 rs111640545 chr1:3752792 G/A cg17848003 chr1:3704513 LRRC47 0.24 7.82 0.3 2.17e-14 Red cell distribution width; BRCA cis rs1153858 1.000 rs10519021 chr15:45631795 G/A cg21132104 chr15:45694354 SPATA5L1 0.71 15.3 0.52 2.88e-45 Homoarginine levels; BRCA cis rs752010 0.543 rs1570355 chr1:42042317 C/T cg06885757 chr1:42089581 HIVEP3 0.23 8.68 0.32 3.29e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6964587 1.000 rs9690208 chr7:91735613 T/A cg17063962 chr7:91808500 NA 0.54 12.83 0.45 1.06e-33 Breast cancer; BRCA cis rs72781680 0.848 rs6754694 chr2:24155448 T/C cg20701182 chr2:24300061 SF3B14 0.59 9.13 0.34 8.97e-19 Lymphocyte counts; BRCA cis rs701145 0.585 rs1527799 chr3:153811226 A/G cg17054900 chr3:154042577 DHX36 0.53 8.92 0.33 4.83e-18 Coronary artery disease; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -14.24 -0.49 3.78e-40 Platelet count; BRCA cis rs6835098 0.924 rs12639929 chr4:174156538 C/T cg08422745 chr4:174089978 GALNT7 -0.81 -15.62 -0.53 8.05e-47 Dementia and core Alzheimer's disease neuropathologic changes; BRCA trans rs17685 0.712 rs10271413 chr7:75754858 G/A cg19862616 chr7:65841803 NCRNA00174 0.81 26.35 0.72 3.8e-104 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg06550200 chr5:1325588 CLPTM1L -0.57 -11.98 -0.43 5.39e-30 Lung cancer; BRCA cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg08645402 chr16:4508243 NA 0.39 8.99 0.33 2.86e-18 Schizophrenia; BRCA cis rs7635838 0.619 rs346087 chr3:11274354 A/G cg00170343 chr3:11313890 ATG7 0.43 8.44 0.32 2.09e-16 HDL cholesterol; BRCA cis rs2180341 0.960 rs7773484 chr6:127670779 T/C cg24812749 chr6:127587940 RNF146 0.87 20.07 0.62 7.99e-70 Breast cancer; BRCA cis rs28735056 0.967 rs498541 chr18:77589655 G/A cg20368463 chr18:77673604 PQLC1 -0.34 -8.08 -0.3 3.36e-15 Schizophrenia; BRCA cis rs838147 0.505 rs1688264 chr19:49209560 T/G cg21064579 chr19:49206444 FUT2 0.32 8.02 0.3 4.92e-15 Dietary macronutrient intake; BRCA cis rs4243830 0.737 rs11581831 chr1:6609958 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.89 -17.62 -0.57 6.1e-57 Body mass index; BRCA trans rs8073060 0.586 rs226087 chr17:34017652 T/C cg19694781 chr19:47549865 TMEM160 -1.07 -21.69 -0.65 1.28e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs6433895 0.677 rs35076700 chr2:181999324 C/T cg00481216 chr2:181971175 NA 0.46 8.68 0.32 3.35e-17 Lymphocyte counts; BRCA cis rs7737355 0.947 rs244733 chr5:130822778 T/C cg06307176 chr5:131281290 NA 0.53 10.43 0.38 1.26e-23 Life satisfaction; BRCA cis rs6060717 0.536 rs6060666 chr20:34478954 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.08 -0.3 3.21e-15 Hip circumference adjusted for BMI; BRCA cis rs10751667 0.600 rs1128413 chr11:1010694 C/T ch.11.42038R chr11:967971 AP2A2 0.46 14.07 0.49 2.37e-39 Alzheimer's disease (late onset); BRCA cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg11890956 chr21:40555474 PSMG1 0.99 23.8 0.69 3.96e-90 Cognitive function; BRCA trans rs11039798 0.588 rs10838923 chr11:48534864 C/G cg15704280 chr7:45808275 SEPT13 0.52 8.96 0.33 3.4e-18 Axial length; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.09 0.3 2.91e-15 Tonsillectomy; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg22920501 chr2:26401640 FAM59B 0.85 15.69 0.53 3.6e-47 Gut microbiome composition (summer); BRCA cis rs1797081 1.000 rs812426 chr10:16857133 C/G cg23933602 chr10:16859644 RSU1 0.98 29.51 0.76 2e-121 Platelet distribution width; BRCA cis rs11190604 1.000 rs7099965 chr10:102301165 A/G cg07080220 chr10:102295463 HIF1AN 0.65 15.51 0.52 2.69e-46 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9467773 1.000 rs1078679 chr6:26568741 C/T cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.4e-57 Intelligence (multi-trait analysis); BRCA cis rs921968 0.541 rs578450 chr2:219401237 C/T cg10223061 chr2:219282414 VIL1 -0.27 -8.12 -0.31 2.37e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs12477438 0.798 rs10202452 chr2:99569409 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.64 -0.5 4.67e-42 Chronic sinus infection; BRCA cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg26647111 chr11:31128758 NA -0.45 -9.83 -0.36 2.5e-21 Red blood cell count; BRCA cis rs9393692 0.905 rs9393693 chr6:26277408 C/A cg13736514 chr6:26305472 NA -0.35 -11.82 -0.42 2.62e-29 Educational attainment; BRCA cis rs2625529 0.824 rs4776581 chr15:72207071 G/A cg16672083 chr15:72433130 SENP8 -0.83 -17.19 -0.56 9.91e-55 Red blood cell count; BRCA cis rs6964587 1.000 rs9690778 chr7:91735299 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.17 0.31 1.63e-15 Breast cancer; BRCA cis rs2806561 0.734 rs2806564 chr1:23506685 T/C cg12483005 chr1:23474871 LUZP1 0.46 10.35 0.38 2.53e-23 Height; BRCA cis rs12367572 0.663 rs1857926 chr12:45344524 C/T cg04608330 chr12:45269318 NELL2 -0.43 -9.48 -0.35 4.82e-20 Gut microbiome composition (summer); BRCA cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg03477792 chr4:77819574 ANKRD56 0.66 15.7 0.53 3.38e-47 Emphysema distribution in smoking; BRCA trans rs61931739 0.500 rs35391785 chr12:34444478 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.81 0.36 3.04e-21 Morning vs. evening chronotype; BRCA cis rs7586879 0.789 rs36029941 chr2:25127801 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.46 0.35 5.74e-20 Body mass index; BRCA cis rs6088813 1.000 rs6088820 chr20:33987298 T/C cg14752227 chr20:34000481 UQCC -0.39 -8.4 -0.32 2.84e-16 Height; BRCA cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg04025307 chr7:1156635 C7orf50 0.43 9.51 0.35 3.91e-20 Longevity;Endometriosis; BRCA cis rs4302748 0.818 rs1882064 chr7:36188616 G/A cg24442661 chr7:36192818 EEPD1 0.47 8.81 0.33 1.19e-17 Platelet count; BRCA cis rs1707322 0.716 rs28375469 chr1:46195375 T/C cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10129255 0.500 rs7157975 chr14:107212287 G/A cg07958169 chr14:107095056 NA -0.38 -8.27 -0.31 8.06e-16 Kawasaki disease; BRCA cis rs10056811 0.510 rs10058171 chr5:74407991 C/T cg19683494 chr5:74908142 NA 0.56 8.5 0.32 1.38e-16 Coronary artery disease; BRCA cis rs7851660 0.933 rs12341377 chr9:100610382 C/G cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.81e-17 Strep throat; BRCA cis rs9653442 0.835 rs11885529 chr2:100746935 A/G cg22139774 chr2:100720529 AFF3 -0.3 -8.6 -0.32 5.97e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg06640241 chr16:89574553 SPG7 0.83 20.76 0.63 1.52e-73 Multiple myeloma (IgH translocation); BRCA cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg14983838 chr19:29218262 NA 0.54 10.11 0.37 2.21e-22 Methadone dose in opioid dependence; BRCA cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg21770322 chr7:97807741 LMTK2 -0.44 -11.53 -0.42 4.46e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs11622475 1.000 rs2236246 chr14:104379206 A/C cg12183467 chr14:104352244 NA 0.46 9.67 0.36 9.7e-21 Bipolar disorder; BRCA cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg12365402 chr11:9010492 NRIP3 -0.4 -9.38 -0.35 1.12e-19 Hemoglobin concentration; BRCA cis rs7666738 0.830 rs13138051 chr4:99050367 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs1997103 1.000 rs6966183 chr7:55407546 A/C cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7582180 0.614 rs9973737 chr2:100942296 T/C cg14675211 chr2:100938903 LONRF2 0.43 9.54 0.35 2.99e-20 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg21724239 chr8:58056113 NA 0.57 9.24 0.34 3.58e-19 Developmental language disorder (linguistic errors); BRCA cis rs11025559 1.000 rs11025559 chr11:20443875 A/G cg19653624 chr11:20408972 PRMT3 0.38 8.12 0.31 2.38e-15 Pursuit maintenance gain; BRCA cis rs1577917 0.958 rs12660846 chr6:86573809 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.43 -0.41 1.14e-27 Response to antipsychotic treatment; BRCA cis rs9487051 0.708 rs378447 chr6:109526823 G/A cg01475377 chr6:109611718 NA -0.41 -10.27 -0.38 5.22e-23 Reticulocyte fraction of red cells; BRCA cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg02951883 chr7:2050386 MAD1L1 -0.52 -11.42 -0.41 1.32e-27 Bipolar disorder and schizophrenia; BRCA cis rs1997103 0.705 rs56301138 chr7:55396555 G/T cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00802000 chr16:706648 WDR90 -0.39 -9.1 -0.34 1.14e-18 Height; BRCA cis rs3750965 0.959 rs2253658 chr11:68856804 C/G cg06818126 chr11:68850279 TPCN2 -0.36 -8.43 -0.32 2.26e-16 Hair color; BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg24642844 chr7:1081250 C7orf50 -0.52 -11.55 -0.42 3.66e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA cis rs2425143 1.000 rs6060642 chr20:34449840 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.56 -0.32 8.47e-17 Blood protein levels; BRCA cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg00071950 chr4:10020882 SLC2A9 0.53 13.2 0.46 2.34e-35 Bone mineral density; BRCA cis rs13190036 1.000 rs34832871 chr5:176655929 A/G cg06733329 chr5:176740039 MXD3 0.45 8.2 0.31 1.33e-15 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg24308560 chr3:49941425 MST1R -0.39 -8.19 -0.31 1.45e-15 Intelligence (multi-trait analysis); BRCA cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.68 -0.32 3.36e-17 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -18.16 -0.58 1.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs12142240 0.698 rs72677593 chr1:46824363 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg13770153 chr20:60521292 NA -0.46 -10.99 -0.4 7.66e-26 Body mass index; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg03923535 chr7:1197113 ZFAND2A 0.43 8.58 0.32 7.16e-17 Longevity;Endometriosis; BRCA cis rs7631605 1.000 rs4647277 chr3:37058509 A/G cg15934958 chr3:37212084 LRRFIP2 0.39 9.07 0.34 1.5e-18 Cerebrospinal P-tau181p levels; BRCA trans rs11098499 0.954 rs10024844 chr4:120311528 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg09658497 chr7:2847517 GNA12 -0.41 -8.56 -0.32 8.71e-17 Height; BRCA cis rs72772090 0.539 rs11740375 chr5:96112897 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -11.61 -0.42 2.09e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.54 -0.59 9.69e-62 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6782228 0.606 rs6439135 chr3:128358633 G/A cg16766828 chr3:128327626 NA -0.43 -9.64 -0.36 1.26e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.943 rs9917081 chr19:37876616 T/C cg18154014 chr19:37997991 ZNF793 0.61 11.42 0.41 1.34e-27 Coronary artery calcification; BRCA cis rs17253792 0.822 rs75995456 chr14:56073194 A/G cg01858014 chr14:56050164 KTN1 -0.74 -9.1 -0.34 1.12e-18 Putamen volume; BRCA cis rs514406 0.644 rs928451 chr1:53195800 A/G cg08859206 chr1:53392774 SCP2 0.42 8.31 0.31 5.65e-16 Monocyte count; BRCA cis rs6840360 0.571 rs4696276 chr4:152532682 G/A cg22705602 chr4:152727874 NA -0.33 -8.26 -0.31 8.67e-16 Intelligence (multi-trait analysis); BRCA cis rs7177699 0.557 rs7165902 chr15:79115872 T/G cg00540400 chr15:79124168 NA 0.27 7.81 0.3 2.44e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs6547741 0.743 rs7564625 chr2:27862397 C/T cg27432699 chr2:27873401 GPN1 -0.53 -11.24 -0.41 7.05e-27 Oral cavity cancer; BRCA cis rs7000551 0.606 rs7844699 chr8:22248920 G/T cg12081754 chr8:22256438 SLC39A14 -0.64 -13.23 -0.46 1.67e-35 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg09184832 chr6:79620586 NA -0.52 -11.42 -0.41 1.3e-27 Intelligence (multi-trait analysis); BRCA cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.52 0.41 5.17e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2766692 1.000 rs2766692 chr14:100684192 C/T cg14866419 chr14:100704911 YY1 0.43 8.91 0.33 5.15e-18 Electroencephalographic traits in alcoholism; BRCA cis rs9399137 0.507 rs11759062 chr6:135381248 A/C cg24558204 chr6:135376177 HBS1L 0.59 15.99 0.53 1.14e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1153858 1.000 rs2066090 chr15:45650018 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs1691799 0.899 rs1168317 chr12:66746225 C/T cg16791601 chr12:66731901 HELB -0.69 -19.72 -0.62 5.51e-68 White blood cell count (basophil); BRCA cis rs11190604 1.000 rs2495742 chr10:102331364 C/T cg07080220 chr10:102295463 HIF1AN 0.62 13.45 0.47 1.67e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -14.72 -0.5 1.98e-42 Initial pursuit acceleration; BRCA cis rs6120849 0.754 rs11167253 chr20:33614449 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.29 0.38 4.57e-23 Protein C levels; BRCA cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -9.45 -0.35 6.26e-20 Joint mobility (Beighton score); BRCA cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.69 0.42 9.8e-29 Homoarginine levels; BRCA cis rs208520 0.690 rs207118 chr6:66788948 T/A cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs631288 0.557 rs894470 chr1:146671947 A/G cg25205988 chr1:146714368 CHD1L 0.82 8.08 0.3 3.13e-15 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg01579765 chr21:45077557 HSF2BP -0.4 -10.55 -0.39 4.39e-24 Mean corpuscular volume; BRCA cis rs2762353 0.574 rs9467573 chr6:25704190 C/A cg12310025 chr6:25882481 NA 0.72 17.43 0.57 5.62e-56 Blood metabolite levels; BRCA cis rs919433 0.617 rs4850807 chr2:198575975 G/A cg00792783 chr2:198669748 PLCL1 -0.44 -9.67 -0.36 9.55e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs250677 0.522 rs10477400 chr5:148359598 T/C cg18129178 chr5:148520854 ABLIM3 0.54 10.46 0.38 9.85e-24 Breast cancer; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18301423 chr5:131593218 PDLIM4 0.35 8.78 0.33 1.52e-17 Acylcarnitine levels; BRCA cis rs992157 0.710 rs6752254 chr2:219058743 C/T cg00012203 chr2:219082015 ARPC2 0.64 14.31 0.49 1.64e-40 Colorectal cancer; BRCA cis rs9486715 1.000 rs11153082 chr6:97059666 A/G cg06623918 chr6:96969491 KIAA0776 -0.84 -23.15 -0.68 1.44e-86 Headache; BRCA cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.66 0.39 1.58e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs11605924 0.868 rs34043764 chr11:45837457 G/A ch.11.939596F chr11:45881766 CRY2 -0.45 -9.65 -0.36 1.13e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs490234 0.615 rs2819625 chr9:128156648 A/G cg14078157 chr9:128172775 NA -0.35 -7.82 -0.3 2.26e-14 Mean arterial pressure; BRCA cis rs10751667 0.600 rs4076915 chr11:1012464 C/G cg06064525 chr11:970664 AP2A2 -0.28 -8.21 -0.31 1.24e-15 Alzheimer's disease (late onset); BRCA cis rs10789491 1.000 rs618505 chr1:47144532 T/C cg15501359 chr1:47185051 KIAA0494 0.65 18.1 0.58 1.93e-59 Response to hepatitis C treatment; BRCA trans rs35110281 0.667 rs4819291 chr21:45123139 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.6 0.32 6.06e-17 Mean corpuscular volume; BRCA cis rs6484504 0.532 rs7121949 chr11:31288160 G/T cg06552810 chr11:31128660 NA -0.39 -8.76 -0.33 1.77e-17 Red blood cell count; BRCA cis rs528301 0.833 rs578584 chr2:45143175 A/T cg02372786 chr2:45167549 SIX3 0.48 11.18 0.4 1.26e-26 Alcohol and nicotine co-dependence; BRCA cis rs600806 0.850 rs1880670 chr1:109941133 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.15 0.34 7.63e-19 Tonsillectomy; BRCA cis rs17023223 0.553 rs56234947 chr1:119707744 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.06 -0.3 3.75e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs17376456 0.877 rs12109629 chr5:93359702 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.97 0.33 3.29e-18 Diabetic retinopathy; BRCA cis rs10493773 0.775 rs11161662 chr1:86185040 A/G cg17807903 chr1:86174739 ZNHIT6 -0.46 -10.45 -0.38 1.09e-23 Urate levels in overweight individuals; BRCA cis rs17401966 1.000 rs17401966 chr1:10385471 C/T cg03954927 chr1:10346856 KIF1B -0.45 -12.9 -0.45 5.21e-34 Hepatocellular carcinoma; BRCA cis rs9837602 1.000 rs1021103 chr3:99603230 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.44 0.41 1.05e-27 Breast cancer; BRCA cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg22029157 chr1:209979665 IRF6 0.55 12.16 0.43 9.7e-31 Cleft lip with or without cleft palate; BRCA cis rs3008870 0.755 rs2815365 chr1:67499628 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 12.96 0.46 2.93e-34 Lymphocyte percentage of white cells; BRCA cis rs7191439 0.589 rs11076699 chr16:88756812 A/C cg02389323 chr16:88786976 FAM38A -0.61 -8.1 -0.31 2.73e-15 Plateletcrit; BRCA trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg03929089 chr4:120376271 NA 0.65 12.8 0.45 1.46e-33 Coronary artery disease; BRCA cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 9.24 0.34 3.62e-19 Personality dimensions; BRCA cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg19812747 chr11:111475976 SIK2 0.45 8.23 0.31 1.09e-15 Primary sclerosing cholangitis; BRCA cis rs67981189 0.593 rs7143595 chr14:71522001 A/T cg15816911 chr14:71606274 NA 0.36 8.32 0.31 5.3e-16 Schizophrenia; BRCA cis rs4074536 0.714 rs12023881 chr1:116304301 G/T cg21648376 chr1:116311395 CASQ2 -0.49 -8.67 -0.32 3.54e-17 QRS duration; BRCA cis rs6543140 0.964 rs13390895 chr2:103075499 G/A cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs7523273 0.606 rs1970530 chr1:207924066 G/A cg22525895 chr1:207977042 MIR29B2 0.48 12.18 0.43 7.55e-31 Schizophrenia; BRCA cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg11168104 chr5:1857477 NA -0.33 -8.71 -0.33 2.6e-17 Cardiovascular disease risk factors; BRCA cis rs798554 0.591 rs757791 chr7:2867296 A/G cg09658497 chr7:2847517 GNA12 -0.43 -8.85 -0.33 8.31e-18 Height; BRCA cis rs7772486 0.817 rs2144477 chr6:146406248 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.8 -0.33 1.3e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.704 rs798513 chr7:2782493 C/T cg04166393 chr7:2884313 GNA12 0.41 8.52 0.32 1.15e-16 Height; BRCA cis rs2836974 0.897 rs7280375 chr21:40552408 C/T cg11644478 chr21:40555479 PSMG1 -0.83 -18.96 -0.6 6.27e-64 Cognitive function; BRCA cis rs12200560 0.505 rs9400167 chr6:97077192 G/T cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA trans rs1459104 1.000 rs35882309 chr11:55237464 G/A cg15704280 chr7:45808275 SEPT13 0.67 8.35 0.31 4.13e-16 Body mass index; BRCA cis rs611744 0.647 rs7015240 chr8:109262204 G/A cg21045802 chr8:109455806 TTC35 0.34 7.83 0.3 2.1e-14 Dupuytren's disease; BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg18402987 chr7:1209562 NA 0.66 11.24 0.41 7.04e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg11707556 chr5:10655725 ANKRD33B 0.4 8.79 0.33 1.33e-17 Coronary artery disease; BRCA cis rs6964587 0.626 rs10266424 chr7:91503228 C/T cg17063962 chr7:91808500 NA -0.55 -12.69 -0.45 4.37e-33 Breast cancer; BRCA cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs1451375 0.617 rs10277662 chr7:50594836 C/T cg18232548 chr7:50535776 DDC 0.44 9.29 0.34 2.44e-19 Malaria; BRCA cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg06784218 chr1:46089804 CCDC17 -0.45 -10.73 -0.39 7.88e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4718428 0.705 rs13220977 chr7:66337648 A/T cg12165864 chr7:66369176 NA 0.41 9.43 0.35 7.58e-20 Corneal structure; BRCA cis rs875971 0.862 rs1875057 chr7:65731855 A/G cg11764359 chr7:65958608 NA -0.75 -16.67 -0.55 4.55e-52 Aortic root size; BRCA cis rs1784581 1.000 rs1618170 chr6:162400337 C/T cg17173639 chr6:162384350 PARK2 -0.43 -10.1 -0.37 2.33e-22 Itch intensity from mosquito bite; BRCA cis rs2075371 0.933 rs2544191 chr7:133954248 A/G cg11752832 chr7:134001865 SLC35B4 0.5 12.74 0.45 2.81e-33 Mean platelet volume; BRCA trans rs1005277 0.579 rs176838 chr10:38371899 A/T cg17830980 chr10:43048298 ZNF37B 0.57 13.98 0.48 5.97e-39 Extrinsic epigenetic age acceleration; BRCA cis rs12893668 0.514 rs3212090 chr14:104168863 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.73 -0.33 2.17e-17 Reticulocyte count; BRCA cis rs9399135 0.967 rs6902954 chr6:135313994 C/A cg24558204 chr6:135376177 HBS1L 0.47 12.88 0.45 6.62e-34 Red blood cell count; BRCA cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg00750074 chr16:89608354 SPG7 -0.38 -10.05 -0.37 3.72e-22 Multiple myeloma (IgH translocation); BRCA cis rs11690935 0.959 rs10204501 chr2:172588865 C/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.46 -0.77 1.51e-126 Schizophrenia; BRCA cis rs28595532 0.920 rs112016126 chr4:119726528 C/T cg21605333 chr4:119757512 SEC24D 1.33 13.92 0.48 1.18e-38 Cannabis dependence symptom count; BRCA cis rs9868809 0.505 rs13316551 chr3:48745167 A/C cg07636037 chr3:49044803 WDR6 -0.58 -8.06 -0.3 3.81e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs10193935 0.901 rs3755304 chr2:42589921 A/G cg27598129 chr2:42591480 NA 0.84 13.53 0.47 7.76e-37 Colonoscopy-negative controls vs population controls; BRCA cis rs9527 0.590 rs1807298 chr10:104870218 G/A cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.13e-24 Arsenic metabolism; BRCA cis rs2180341 0.814 rs9401959 chr6:127736464 T/C cg27446573 chr6:127587934 RNF146 0.67 15.13 0.51 2.02e-44 Breast cancer; BRCA cis rs12612619 0.732 rs11897106 chr2:27196299 A/G cg00617064 chr2:27272375 NA 0.31 8.34 0.31 4.65e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs17270561 0.583 rs9393661 chr6:25739080 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.8 0.33 1.28e-17 Iron status biomarkers; BRCA cis rs7267979 0.934 rs2500399 chr20:25354694 T/G cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg11644478 chr21:40555479 PSMG1 0.83 19.11 0.6 1.01e-64 Cognitive function; BRCA cis rs11229555 0.609 rs12291791 chr11:58186290 C/T cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.23e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs477895 0.713 rs882146 chr11:63976699 G/A cg04317338 chr11:64019027 PLCB3 0.56 9.72 0.36 6.35e-21 Mean platelet volume; BRCA cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg03264133 chr6:25882463 NA 0.49 11.06 0.4 3.9e-26 Blood metabolite levels; BRCA cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg25174290 chr11:3078921 CARS -0.44 -13.64 -0.47 2.19e-37 Longevity; BRCA cis rs965469 1.000 rs6051705 chr20:3253143 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -10.79 -0.39 4.75e-25 IFN-related cytopenia; BRCA cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.38 -9.68 -0.36 9.31e-21 Blood protein levels;Circulating chemerin levels; BRCA cis rs7727544 0.508 rs10900804 chr5:131401845 C/T cg14196790 chr5:131705035 SLC22A5 0.38 9.31 0.35 2.07e-19 Blood metabolite levels; BRCA cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg01448562 chr3:133502909 NA -0.6 -14.43 -0.5 4.46e-41 Iron status biomarkers; BRCA cis rs1904096 0.506 rs6823404 chr4:95197520 C/T cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.15 -0.37 1.51e-22 Type 2 diabetes; BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg25036284 chr2:26402008 FAM59B -0.77 -12.17 -0.43 8.78e-31 Gut microbiome composition (summer); BRCA cis rs13392177 0.672 rs4674270 chr2:219053141 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.39 -8.33 -0.31 4.78e-16 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg07636037 chr3:49044803 WDR6 0.57 9.26 0.34 3e-19 Menarche (age at onset); BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg04981885 chr1:160991156 F11R -0.63 -11.62 -0.42 1.94e-28 Granulocyte percentage of myeloid white cells; BRCA cis rs4642101 0.597 rs9839769 chr3:12821405 C/T cg05775895 chr3:12838266 CAND2 0.38 8.49 0.32 1.44e-16 QRS complex (12-leadsum); BRCA cis rs899997 0.862 rs8043123 chr15:78973393 C/T cg04896959 chr15:78267971 NA -0.42 -9.94 -0.37 9.23e-22 Coronary artery disease or large artery stroke; BRCA cis rs9549367 0.789 rs9577218 chr13:113894911 A/G cg18105134 chr13:113819100 PROZ -0.61 -13.99 -0.48 5.45e-39 Platelet distribution width; BRCA cis rs778371 0.697 rs4973564 chr2:233718440 A/G cg08000102 chr2:233561755 GIGYF2 -0.85 -20.72 -0.63 2.32e-73 Schizophrenia; BRCA cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg14500267 chr11:67383377 NA 0.4 8.55 0.32 9.37e-17 Mean corpuscular volume; BRCA cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.69 -14.26 -0.49 2.95e-40 Chronic sinus infection; BRCA trans rs78049276 0.688 rs1878406 chr4:148393664 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.45 -7.81 -0.3 2.42e-14 Pulse pressure; BRCA cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg04450456 chr4:17643702 FAM184B 0.37 11.09 0.4 3.01e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs72717009 0.825 rs12746613 chr1:161467042 A/G cg23840854 chr1:161414152 NA 0.74 9.86 0.36 1.87e-21 Rheumatoid arthritis; BRCA cis rs9462846 0.959 rs6937172 chr6:42884375 A/T cg02353165 chr6:42928485 GNMT 0.54 9.71 0.36 7.04e-21 Blood protein levels; BRCA cis rs10911251 0.546 rs1062044 chr1:183112412 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA trans rs6598955 0.671 rs12116908 chr1:26587918 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs28830936 0.966 rs17733613 chr15:41917585 A/G cg17847044 chr15:42102381 MAPKBP1 -0.32 -9.0 -0.34 2.66e-18 Diastolic blood pressure; BRCA cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg04546413 chr19:29218101 NA 0.58 9.9 0.36 1.34e-21 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs6831352 0.918 rs17817958 chr4:100061245 A/C cg12011299 chr4:100065546 ADH4 0.47 10.65 0.39 1.7e-24 Alcohol dependence; BRCA cis rs911555 0.755 rs2756132 chr14:103967820 C/G cg12935359 chr14:103987150 CKB 0.61 14.08 0.49 1.99e-39 Intelligence (multi-trait analysis); BRCA trans rs7618501 0.933 rs1128535 chr3:49866392 C/T cg21659725 chr3:3221576 CRBN 0.72 22.39 0.66 1.95e-82 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.638 rs12425531 chr12:38550387 A/G cg26384229 chr12:38710491 ALG10B -0.44 -10.28 -0.38 4.86e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs6570726 0.905 rs421032 chr6:145827771 A/G cg23711669 chr6:146136114 FBXO30 0.65 15.41 0.52 8.21e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs40363 0.672 rs1617722 chr16:3520806 C/T cg21433313 chr16:3507492 NAT15 -0.4 -8.7 -0.33 2.87e-17 Tuberculosis; BRCA cis rs113835537 0.529 rs11227495 chr11:66263243 C/T cg24851651 chr11:66362959 CCS 0.45 8.36 0.31 3.93e-16 Airway imaging phenotypes; BRCA cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA trans rs2018683 0.707 rs4722878 chr7:28973031 C/T cg19402173 chr7:128379420 CALU -0.42 -9.88 -0.36 1.63e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg08999081 chr20:33150536 PIGU 0.45 12.54 0.44 2.02e-32 Glomerular filtration rate (creatinine); BRCA trans rs1005277 0.579 rs1780121 chr10:38529437 C/A cg23533926 chr12:111358616 MYL2 -0.43 -8.95 -0.33 3.88e-18 Extrinsic epigenetic age acceleration; BRCA cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg15017067 chr4:17643749 FAM184B 0.31 9.56 0.35 2.54e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2576037 0.526 rs10853545 chr18:44475220 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.61 -12.93 -0.46 4.08e-34 Personality dimensions; BRCA cis rs11190604 1.000 rs2495741 chr10:102331795 A/G cg07080220 chr10:102295463 HIF1AN 0.56 12.79 0.45 1.62e-33 Palmitoleic acid (16:1n-7) levels; BRCA cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg18451016 chr1:38461880 NA 0.49 11.49 0.41 6.34e-28 Coronary artery disease; BRCA cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg23887609 chr12:130822674 PIWIL1 0.49 10.69 0.39 1.22e-24 Menopause (age at onset); BRCA cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg20476274 chr7:133979776 SLC35B4 0.51 11.82 0.42 2.78e-29 Mean platelet volume; BRCA cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.95e-32 Developmental language disorder (linguistic errors); BRCA trans rs7824557 0.767 rs17797443 chr8:11164012 T/C cg08975724 chr8:8085496 FLJ10661 0.43 8.05 0.3 3.95e-15 Retinal vascular caliber; BRCA cis rs7824557 0.592 rs2572371 chr8:11223793 G/T cg21775007 chr8:11205619 TDH 0.58 13.28 0.47 1.02e-35 Retinal vascular caliber; BRCA cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg12373951 chr3:133503437 NA 0.44 10.19 0.37 1.11e-22 Iron status biomarkers; BRCA cis rs733592 0.723 rs10875766 chr12:48593580 G/C cg24011408 chr12:48396354 COL2A1 0.39 8.11 0.31 2.58e-15 Plateletcrit; BRCA cis rs4908768 0.501 rs4908761 chr1:8552219 G/A cg20416874 chr1:8611966 RERE -0.27 -7.81 -0.3 2.43e-14 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg13047869 chr3:10149882 C3orf24 0.57 10.37 0.38 2.19e-23 Alzheimer's disease; BRCA cis rs73086581 1.000 rs73086588 chr20:3982224 A/T cg02187196 chr20:3869020 PANK2 0.53 9.37 0.35 1.23e-19 Response to antidepressants in depression; BRCA cis rs1008375 0.933 rs7689101 chr4:17694034 G/A cg16339924 chr4:17578868 LAP3 0.56 13.86 0.48 2.31e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs870825 0.655 rs10013685 chr4:185617785 C/T cg04058563 chr4:185651563 MLF1IP 0.77 16.77 0.55 1.36e-52 Blood protein levels; BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg08888203 chr3:10149979 C3orf24 0.57 12.08 0.43 2.15e-30 Alzheimer's disease; BRCA cis rs9318086 0.712 rs1886970 chr13:24440498 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.33 9.6 0.35 1.85e-20 Myopia (pathological); BRCA cis rs2073300 1.000 rs6137957 chr20:23437384 G/A cg12062639 chr20:23401060 NAPB 0.89 10.64 0.39 1.94e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs8073060 0.544 rs225246 chr17:33944773 T/C cg19694781 chr19:47549865 TMEM160 -1.06 -21.52 -0.65 1.07e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs12618769 0.597 rs6753515 chr2:99128965 T/A cg10123293 chr2:99228465 UNC50 0.41 8.33 0.31 4.95e-16 Bipolar disorder; BRCA cis rs13095912 0.962 rs1568664 chr3:185312231 T/C cg11274856 chr3:185301563 NA 0.36 9.05 0.34 1.74e-18 Systolic blood pressure; BRCA cis rs7617773 0.780 rs35411187 chr3:48360017 C/G cg11946769 chr3:48343235 NME6 0.7 14.13 0.49 1.21e-39 Coronary artery disease; BRCA cis rs3096299 0.685 rs12935112 chr16:89542858 C/T cg08392591 chr16:89556376 ANKRD11 -0.43 -10.52 -0.38 5.51e-24 Multiple myeloma (IgH translocation); BRCA cis rs1451375 1.000 rs921450 chr7:50623260 A/G cg18232548 chr7:50535776 DDC -0.42 -9.96 -0.37 8.35e-22 Malaria; BRCA cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg03264133 chr6:25882463 NA -0.54 -12.39 -0.44 9.07e-32 Blood metabolite levels; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg11843238 chr5:131593191 PDLIM4 0.33 8.72 0.33 2.34e-17 Breast cancer; BRCA cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg24562669 chr7:97807699 LMTK2 0.45 12.08 0.43 2.16e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg18904891 chr8:8559673 CLDN23 0.62 12.42 0.44 7.03e-32 Obesity-related traits; BRCA cis rs965469 0.779 rs8117749 chr20:3386692 A/C cg25506879 chr20:3388711 C20orf194 -0.45 -8.78 -0.33 1.51e-17 IFN-related cytopenia; BRCA cis rs2762353 1.000 rs2762353 chr6:25794431 A/G cg03264133 chr6:25882463 NA -0.48 -10.77 -0.39 5.48e-25 Blood metabolite levels; BRCA cis rs2070433 1.000 rs2839306 chr21:47954219 G/T cg12379764 chr21:47803548 PCNT -0.48 -8.9 -0.33 5.87e-18 Lymphocyte counts; BRCA cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg20607798 chr8:58055168 NA 0.46 7.92 0.3 1.08e-14 Developmental language disorder (linguistic errors); BRCA cis rs3772130 1.000 rs13087578 chr3:121369207 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.52 8.97 0.33 3.29e-18 Cognitive performance; BRCA cis rs9309473 0.607 rs6546826 chr2:73599808 A/G cg20560298 chr2:73613845 ALMS1 0.47 12.79 0.45 1.69e-33 Metabolite levels; BRCA cis rs7092929 0.941 rs1890583 chr10:3590269 T/C cg14308648 chr10:3568949 NA 0.44 8.01 0.3 5.47e-15 Coronary artery calcification; BRCA cis rs703842 0.928 rs724834 chr12:58180416 G/C cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.07 0.43 2.31e-30 Multiple sclerosis; BRCA cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg16339924 chr4:17578868 LAP3 0.56 13.89 0.48 1.62e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13064411 0.735 rs13098166 chr3:113210038 A/G cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs1595825 0.838 rs6742343 chr2:198666752 C/T cg19156104 chr2:198669113 PLCL1 -0.48 -8.58 -0.32 7.39e-17 Ulcerative colitis; BRCA cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg04267008 chr7:1944627 MAD1L1 -0.41 -9.11 -0.34 1.04e-18 Schizophrenia; BRCA cis rs9837602 0.882 rs6807176 chr3:99760864 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 10.3 0.38 3.87e-23 Breast cancer; BRCA cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.86 0.55 4.76e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs61931739 0.500 rs11053201 chr12:34453903 T/A cg06521331 chr12:34319734 NA -0.56 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg18765753 chr7:1198926 ZFAND2A -0.42 -8.68 -0.32 3.18e-17 Bronchopulmonary dysplasia; BRCA cis rs2816062 0.735 rs2816054 chr1:18896431 C/T cg18795169 chr1:18902165 NA -0.98 -29.92 -0.76 1.28e-123 Urate levels in lean individuals; BRCA cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg18132916 chr6:79620363 NA -0.47 -10.74 -0.39 7.41e-25 Intelligence (multi-trait analysis); BRCA cis rs9811920 0.535 rs792831 chr3:99473720 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.99 -0.37 6.28e-22 Axial length; BRCA cis rs950776 0.593 rs601079 chr15:78869579 T/A cg06917634 chr15:78832804 PSMA4 -0.58 -12.85 -0.45 8.77e-34 Sudden cardiac arrest; BRCA cis rs12579753 0.917 rs2401003 chr12:82215192 G/A cg07988820 chr12:82153109 PPFIA2 -0.49 -8.33 -0.31 4.84e-16 Resting heart rate; BRCA cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg04455712 chr21:45112962 RRP1B 0.44 11.01 0.4 6.38e-26 Mean corpuscular volume; BRCA cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.5 0.5 2.14e-41 Personality dimensions; BRCA cis rs6433857 0.657 rs10209994 chr2:181514955 A/C cg23363182 chr2:181467187 NA -0.45 -9.49 -0.35 4.64e-20 Body mass index; BRCA trans rs2832077 0.943 rs11701777 chr21:30155828 T/C cg14791747 chr16:20752902 THUMPD1 0.41 9.83 0.36 2.53e-21 Cognitive test performance; BRCA cis rs68170813 0.559 rs6964798 chr7:106933013 C/G cg02696742 chr7:106810147 HBP1 -0.53 -8.68 -0.32 3.31e-17 Coronary artery disease; BRCA cis rs6429082 0.807 rs4659857 chr1:235581411 C/T cg26050004 chr1:235667680 B3GALNT2 -0.55 -13.7 -0.48 1.16e-37 Adiposity; BRCA cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.89 -0.3 1.29e-14 Menopause (age at onset); BRCA cis rs10791323 0.593 rs2282604 chr11:133714672 A/G cg15485101 chr11:133734466 NA 0.41 10.11 0.37 2.08e-22 Childhood ear infection; BRCA cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg19748678 chr4:122722346 EXOSC9 0.74 16.12 0.54 2.75e-49 Type 2 diabetes; BRCA cis rs490234 0.676 rs4838264 chr9:128225561 T/C cg14078157 chr9:128172775 NA -0.5 -11.14 -0.4 1.81e-26 Mean arterial pressure; BRCA cis rs12681288 0.676 rs2600514 chr8:994175 G/A cg04851639 chr8:1020857 NA -0.36 -10.11 -0.37 2.23e-22 Schizophrenia; BRCA cis rs6426558 0.537 rs6685823 chr1:227270835 A/G cg10327440 chr1:227177885 CDC42BPA 0.48 9.56 0.35 2.52e-20 Neutrophil percentage of white cells; BRCA cis rs1018836 0.923 rs10956748 chr8:91621537 T/A cg16814680 chr8:91681699 NA -0.6 -12.89 -0.45 6.02e-34 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs847649 0.732 rs56269620 chr7:102489456 A/G cg18108683 chr7:102477205 FBXL13 -0.53 -13.49 -0.47 1.1e-36 Morning vs. evening chronotype; BRCA cis rs68170813 0.559 rs7793594 chr7:106891829 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.44 -0.32 2.05e-16 Coronary artery disease; BRCA cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg10253484 chr15:75165896 SCAMP2 -0.5 -9.63 -0.36 1.35e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs16958440 0.867 rs79078752 chr18:44667462 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.87 0.48 1.94e-38 Sitting height ratio; BRCA cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg08061076 chr7:1943177 MAD1L1 0.35 8.01 0.3 5.57e-15 Bipolar disorder and schizophrenia; BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg27170947 chr2:26402098 FAM59B -0.65 -11.14 -0.4 1.76e-26 Gut microbiome composition (summer); BRCA cis rs887829 0.588 rs6715325 chr2:234635241 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.35 -9.24 -0.34 3.52e-19 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs6433895 0.809 rs35323141 chr2:181996558 C/G cg00481216 chr2:181971175 NA 0.41 9.43 0.35 7.22e-20 Lymphocyte counts; BRCA cis rs3771570 1.000 rs56363214 chr2:242227157 A/G cg21155796 chr2:242212141 HDLBP 0.59 9.34 0.35 1.52e-19 Prostate cancer; BRCA cis rs6430585 0.528 rs309151 chr2:136661150 C/T cg07169764 chr2:136633963 MCM6 1.06 20.03 0.62 1.27e-69 Corneal structure; BRCA cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg08564027 chr20:61660810 NA 0.82 21.9 0.65 9.93e-80 Prostate cancer (SNP x SNP interaction); BRCA cis rs35110281 0.627 rs7283362 chr21:44973667 C/G cg21573476 chr21:45109991 RRP1B -0.33 -8.69 -0.32 3.15e-17 Mean corpuscular volume; BRCA cis rs514406 0.565 rs897732 chr1:53382816 A/C cg08859206 chr1:53392774 SCP2 -0.63 -13.88 -0.48 1.74e-38 Monocyte count; BRCA cis rs9831754 0.906 rs4680929 chr3:78387591 T/A cg06138941 chr3:78371609 NA -0.76 -16.44 -0.55 6.71e-51 Calcium levels; BRCA cis rs10751667 0.666 rs7950967 chr11:955638 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg16339924 chr4:17578868 LAP3 0.76 19.13 0.6 8.22e-65 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9976767 0.637 rs2156309 chr21:43824529 G/A cg23042151 chr21:43824109 UBASH3A -0.27 -8.6 -0.32 6.12e-17 Type 1 diabetes; BRCA cis rs4865169 0.623 rs6838975 chr4:57739816 G/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.33 -7.81 -0.3 2.33e-14 Breast cancer; BRCA cis rs6546550 0.835 rs3752781 chr2:70124316 T/A cg02498382 chr2:70120550 SNRNP27 -0.52 -11.31 -0.41 3.74e-27 Prevalent atrial fibrillation; BRCA cis rs11250464 0.833 rs2387653 chr10:1407826 A/G cg08668359 chr10:1443807 ADARB2 -0.45 -8.4 -0.32 2.82e-16 Radiation response; BRCA cis rs897080 0.515 rs696595 chr2:44682692 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.2 0.34 4.95e-19 Height; BRCA cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.84 0.36 2.36e-21 Bipolar disorder; BRCA cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg17971929 chr21:40555470 PSMG1 -0.47 -10.42 -0.38 1.38e-23 Menarche (age at onset); BRCA cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4853036 1.000 rs35002543 chr2:70091299 A/G cg02498382 chr2:70120550 SNRNP27 -0.5 -9.07 -0.34 1.49e-18 Colorectal or endometrial cancer; BRCA cis rs11098499 0.739 rs6534130 chr4:120131339 A/T cg09307838 chr4:120376055 NA -0.49 -9.2 -0.34 5.12e-19 Corneal astigmatism; BRCA cis rs11718455 0.767 rs6771202 chr3:43990087 A/T cg08738300 chr3:44038990 NA 0.48 8.96 0.33 3.48e-18 Coronary artery disease; BRCA cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg17158414 chr2:27665306 KRTCAP3 0.31 7.84 0.3 1.89e-14 Total body bone mineral density; BRCA cis rs6840258 1.000 rs17701999 chr4:87955544 C/T cg08197287 chr4:87952173 AFF1 -0.44 -8.95 -0.33 3.86e-18 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg06115741 chr20:33292138 TP53INP2 0.49 10.74 0.39 7.34e-25 Coronary artery disease; BRCA trans rs116095464 0.558 rs10065239 chr5:275288 C/T cg00938859 chr5:1591904 SDHAP3 0.67 9.14 0.34 8.3e-19 Breast cancer; BRCA cis rs4363385 0.818 rs451939 chr1:153006877 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs2933343 0.729 rs1683780 chr3:128640239 C/T cg25356066 chr3:128598488 ACAD9 0.37 8.57 0.32 7.54e-17 IgG glycosylation; BRCA cis rs1568889 1.000 rs11602768 chr11:28351786 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 13.2 0.46 2.45e-35 Bipolar disorder; BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.61 -11.2 -0.41 1e-26 Alzheimer's disease; BRCA cis rs26868 0.690 rs26835 chr16:2237549 C/T cg02248941 chr16:2239361 CASKIN1 0.62 15.27 0.52 4.3e-45 Height; BRCA cis rs1506636 1.000 rs676755 chr7:123439082 A/G cg03229431 chr7:123269106 ASB15 -0.56 -12.44 -0.44 6.02e-32 Plateletcrit;Platelet count; BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg22920501 chr2:26401640 FAM59B 0.79 11.46 0.41 8.77e-28 Gut microbiome composition (summer); BRCA cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg23711669 chr6:146136114 FBXO30 0.79 19.46 0.61 1.38e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg01448562 chr3:133502909 NA 0.62 15.05 0.51 4.7e-44 Iron status biomarkers; BRCA cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.68 -0.32 3.26e-17 Reticulocyte count; BRCA cis rs921968 0.541 rs7583449 chr2:219403022 A/C cg10223061 chr2:219282414 VIL1 0.3 8.36 0.31 3.92e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs6430585 0.528 rs309158 chr2:136680534 A/G cg07169764 chr2:136633963 MCM6 1.08 23.95 0.69 5.98e-91 Corneal structure; BRCA cis rs12950390 0.853 rs28589850 chr17:45855713 A/G cg24803719 chr17:45855879 NA -0.33 -8.71 -0.33 2.68e-17 IgG glycosylation; BRCA cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14442939 chr10:27389572 ANKRD26 0.64 10.93 0.4 1.33e-25 Breast cancer; BRCA cis rs477692 0.507 rs7080570 chr10:131455328 C/T cg05714579 chr10:131428358 MGMT -0.39 -8.75 -0.33 1.96e-17 Response to temozolomide; BRCA cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg01448562 chr3:133502909 NA -0.75 -19.5 -0.61 8.07e-67 Iron status biomarkers; BRCA cis rs72781680 1.000 rs72796316 chr2:24132272 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.09 0.34 1.25e-18 Lymphocyte counts; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg25703541 chr22:24373054 LOC391322 0.93 24.82 0.7 1.02e-95 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4727443 0.866 rs13238380 chr7:99629061 C/T cg22004693 chr7:99632812 ZKSCAN1 0.4 9.05 0.34 1.7e-18 Interstitial lung disease; BRCA trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg27661571 chr11:113659931 NA -0.83 -12.08 -0.43 2.16e-30 Hip circumference adjusted for BMI; BRCA cis rs8114671 0.562 rs6120757 chr20:33488771 C/T cg07148914 chr20:33460835 GGT7 0.41 9.16 0.34 7.04e-19 Height; BRCA cis rs6761276 0.649 rs3811057 chr2:113831188 C/A cg12858261 chr2:113808755 IL1F8 0.43 8.53 0.32 1.1e-16 Protein quantitative trait loci; BRCA trans rs7618501 0.633 rs4688758 chr3:50028385 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.18 0.34 5.69e-19 Intelligence (multi-trait analysis); BRCA cis rs2404602 0.647 rs11072607 chr15:76908529 C/T cg23625390 chr15:77176239 SCAPER -0.57 -14.08 -0.49 2.07e-39 Blood metabolite levels; BRCA cis rs10791323 0.569 rs10750552 chr11:133740141 A/C cg06766960 chr11:133703094 NA 0.44 10.18 0.37 1.21e-22 Childhood ear infection; BRCA cis rs7178375 0.607 rs7171212 chr15:31207711 C/T cg15020726 chr15:31196382 MTMR15 0.5 7.84 0.3 1.9e-14 Hypertriglyceridemia; BRCA cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.73 0.73 3.22e-106 Chronic sinus infection; BRCA cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg20503657 chr10:835505 NA 0.83 14.86 0.51 3.99e-43 Eosinophil percentage of granulocytes; BRCA trans rs7746199 0.673 rs72847313 chr6:27730082 C/T cg06606381 chr12:133084897 FBRSL1 -0.89 -8.85 -0.33 8.51e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg08754478 chr10:133766260 PPP2R2D -0.69 -14.15 -0.49 9.24e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6121246 0.909 rs6089071 chr20:30378384 C/G cg13852791 chr20:30311386 BCL2L1 0.83 16.13 0.54 2.32e-49 Mean corpuscular hemoglobin; BRCA cis rs11098499 1.000 rs28419773 chr4:120211061 T/C cg09307838 chr4:120376055 NA 0.65 13.19 0.46 2.55e-35 Corneal astigmatism; BRCA cis rs13191362 0.935 rs34141091 chr6:162953893 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 11.22 0.41 8.98e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10129255 0.500 rs6576226 chr14:107186374 G/A cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.43e-17 Kawasaki disease; BRCA cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg21856205 chr7:94953877 PON1 -0.37 -7.97 -0.3 7.26e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6484504 0.625 rs10835766 chr11:31374329 C/A cg06552810 chr11:31128660 NA 0.38 8.69 0.32 3.14e-17 Red blood cell count; BRCA cis rs6088590 0.687 rs6088580 chr20:33285053 G/C cg24642439 chr20:33292090 TP53INP2 0.61 13.64 0.47 2.22e-37 Coronary artery disease; BRCA cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.87 -0.33 7.13e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.542 rs7677836 chr4:120310638 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs4727027 0.866 rs35599790 chr7:148806012 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.74 0.33 2.06e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7666738 0.830 rs28687737 chr4:99009226 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.8e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs9858542 0.953 rs11710037 chr3:49675334 C/G cg21659725 chr3:3221576 CRBN -0.48 -10.32 -0.38 3.26e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9649213 0.593 rs7778015 chr7:97920270 T/C cg21770322 chr7:97807741 LMTK2 0.42 11.31 0.41 3.74e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.48 9.61 0.36 1.64e-20 Tonsillectomy; BRCA cis rs897080 0.515 rs1067321 chr2:44631312 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.76 0.33 1.68e-17 Height; BRCA trans rs11098499 0.722 rs1814814 chr4:120258124 C/G cg25214090 chr10:38739885 LOC399744 0.47 11.01 0.4 6.46e-26 Corneal astigmatism; BRCA cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg21573476 chr21:45109991 RRP1B -0.37 -9.68 -0.36 9e-21 Mean corpuscular volume; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg07308232 chr7:1071921 C7orf50 -0.44 -9.58 -0.35 2.17e-20 Longevity;Endometriosis; BRCA cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg06970220 chr1:156163860 SLC25A44 0.39 9.58 0.35 2.19e-20 Testicular germ cell tumor; BRCA cis rs7727544 0.735 rs272894 chr5:131662460 C/T cg24060327 chr5:131705240 SLC22A5 -0.48 -10.17 -0.37 1.28e-22 Blood metabolite levels; BRCA cis rs9787249 0.957 rs6670841 chr1:40220284 C/G cg02773041 chr1:40204384 PPIE 0.45 9.74 0.36 5.51e-21 Blood protein levels; BRCA cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg03808351 chr9:123631620 PHF19 0.39 7.87 0.3 1.53e-14 Rheumatoid arthritis; BRCA cis rs8114671 0.805 rs6060168 chr20:33621017 C/T cg07148914 chr20:33460835 GGT7 0.4 8.88 0.33 6.55e-18 Height; BRCA cis rs4319547 0.910 rs6416298 chr12:123002143 C/T cg23029597 chr12:123009494 RSRC2 -0.66 -12.03 -0.43 3.32e-30 Body mass index; BRCA cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg26384229 chr12:38710491 ALG10B 0.83 22.45 0.66 9.57e-83 Heart rate; BRCA cis rs6977660 0.619 rs10231972 chr7:19789354 C/G cg05791153 chr7:19748676 TWISTNB 0.47 9.43 0.35 7.67e-20 Thyroid stimulating hormone; BRCA cis rs7582180 0.629 rs11686880 chr2:100956229 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.7 0.42 9.01e-29 Intelligence (multi-trait analysis); BRCA cis rs826838 0.967 rs1719853 chr12:39128515 A/G cg26384229 chr12:38710491 ALG10B -0.62 -15.95 -0.53 1.75e-48 Heart rate; BRCA cis rs6835098 0.962 rs4419455 chr4:174083622 C/T cg08422745 chr4:174089978 GALNT7 0.78 16.14 0.54 2.09e-49 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs6089829 0.962 rs2872543 chr20:61665017 G/A cg08564027 chr20:61660810 NA 0.85 23.01 0.67 7.95e-86 Prostate cancer (SNP x SNP interaction); BRCA trans rs61931739 0.500 rs10844864 chr12:34532468 A/G cg26384229 chr12:38710491 ALG10B 0.6 13.57 0.47 4.75e-37 Morning vs. evening chronotype; BRCA cis rs758324 0.947 rs28537859 chr5:131237277 C/G cg06307176 chr5:131281290 NA -0.53 -10.21 -0.37 8.61e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1865721 0.804 rs3826652 chr18:73142153 C/T cg26385618 chr18:73139727 C18orf62 0.39 10.0 0.37 5.85e-22 Intelligence; BRCA cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg08992911 chr2:238395768 MLPH -0.37 -8.2 -0.31 1.35e-15 Prostate cancer; BRCA cis rs528301 0.555 rs340514 chr2:45189011 C/T cg02372786 chr2:45167549 SIX3 -0.43 -9.47 -0.35 5.54e-20 Alcohol and nicotine co-dependence; BRCA cis rs12541635 1.000 rs1540420 chr8:107088426 C/T cg10147462 chr8:107024639 NA -0.3 -8.36 -0.31 4e-16 Age of smoking initiation; BRCA trans rs35110281 0.776 rs9983763 chr21:44990578 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.46 -9.16 -0.34 6.83e-19 Mean corpuscular volume; BRCA cis rs350251 0.868 rs350278 chr16:12232402 T/C cg06014057 chr16:12226852 SNX29 0.29 7.93 0.3 9.65e-15 Intelligence (multi-trait analysis); BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg02951883 chr7:2050386 MAD1L1 -0.49 -10.78 -0.39 5.03e-25 Bipolar disorder and schizophrenia; BRCA cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg16405210 chr4:1374714 KIAA1530 -0.91 -22.72 -0.67 3.2e-84 Longevity; BRCA cis rs778371 0.697 rs2344613 chr2:233603065 C/G cg08000102 chr2:233561755 GIGYF2 0.78 17.25 0.56 5.08e-55 Schizophrenia; BRCA cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.4 8.02 0.3 4.95e-15 Tonsillectomy; BRCA cis rs9921192 0.967 rs3747571 chr16:4323983 A/G cg07945448 chr16:4304224 NA 0.48 9.89 0.36 1.46e-21 Prostate-specific antigen levels; BRCA cis rs58235267 0.553 rs11890276 chr2:63366191 C/T cg17519650 chr2:63277830 OTX1 0.43 9.18 0.34 5.68e-19 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs7312933 0.501 rs3810793 chr12:42729407 C/T cg01256987 chr12:42539512 GXYLT1 -0.42 -8.23 -0.31 1.04e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12618769 0.625 rs3769717 chr2:99124817 G/A cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs4853036 0.597 rs1048165 chr2:70131964 A/C cg02498382 chr2:70120550 SNRNP27 -0.53 -9.52 -0.35 3.52e-20 Colorectal or endometrial cancer; BRCA cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.97e-15 Breast cancer; BRCA cis rs8177253 0.665 rs12639304 chr3:133441594 A/T cg01448562 chr3:133502909 NA -0.39 -8.93 -0.33 4.53e-18 Iron status biomarkers; BRCA cis rs7312933 1.000 rs11181308 chr12:42445259 A/G cg01256987 chr12:42539512 GXYLT1 -0.57 -11.71 -0.42 7.85e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg03188948 chr7:1209495 NA 0.84 11.6 0.42 2.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg22920501 chr2:26401640 FAM59B 0.72 12.28 0.44 2.87e-31 Gut microbiome composition (summer); BRCA cis rs9486715 0.867 rs2475025 chr6:96988696 A/T cg06623918 chr6:96969491 KIAA0776 -0.92 -27.15 -0.73 1.64e-108 Headache; BRCA cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg08213375 chr14:104286397 PPP1R13B -0.64 -17.7 -0.57 2.43e-57 Schizophrenia; BRCA cis rs9309711 0.772 rs9309715 chr2:3492318 C/G cg10845886 chr2:3471009 TTC15 0.74 15.5 0.52 2.99e-46 Neurofibrillary tangles; BRCA cis rs1595825 0.891 rs7587716 chr2:198630667 G/T cg19156104 chr2:198669113 PLCL1 -0.44 -8.33 -0.31 4.87e-16 Ulcerative colitis; BRCA cis rs1215050 0.791 rs2695472 chr4:98855127 T/C cg05340658 chr4:99064831 C4orf37 -0.43 -9.8 -0.36 3.27e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7561273 0.586 rs9309225 chr2:24292863 T/C cg04809136 chr2:24300158 SF3B14 -0.4 -9.28 -0.34 2.62e-19 Quantitative traits; BRCA cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg04317338 chr11:64019027 PLCB3 0.55 9.52 0.35 3.59e-20 Mean platelet volume; BRCA cis rs11098499 0.863 rs7669520 chr4:120515278 T/C cg09307838 chr4:120376055 NA 0.69 14.11 0.49 1.45e-39 Corneal astigmatism; BRCA cis rs1215050 0.791 rs9993992 chr4:98810851 C/G cg05340658 chr4:99064831 C4orf37 0.45 10.14 0.37 1.62e-22 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs6089829 0.962 rs6089826 chr20:61668595 G/A cg15934090 chr1:100435551 SLC35A3 0.36 8.39 0.32 3.12e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg21747090 chr2:27597821 SNX17 -0.44 -9.52 -0.35 3.51e-20 Total body bone mineral density; BRCA cis rs6087771 0.781 rs6089067 chr20:30358894 G/C cg13852791 chr20:30311386 BCL2L1 0.89 20.27 0.63 6.31e-71 Subcortical brain region volumes;Putamen volume; BRCA cis rs9814567 1.000 rs13081177 chr3:134289860 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.78 0.62 2.8e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10751667 0.666 rs4074235 chr11:977511 C/G ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg04455712 chr21:45112962 RRP1B 0.44 11.66 0.42 1.29e-28 Mean corpuscular volume; BRCA cis rs4302748 0.862 rs11971724 chr7:36184708 T/C cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs12971120 0.504 rs11665154 chr18:72147006 A/C cg26446133 chr18:72167187 CNDP2 -0.53 -12.61 -0.45 1.08e-32 Refractive error; BRCA cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg11584989 chr19:19387371 SF4 0.64 13.59 0.47 3.82e-37 Bipolar disorder; BRCA cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg00409905 chr10:38381863 ZNF37A 0.52 11.12 0.4 2.24e-26 Extrinsic epigenetic age acceleration; BRCA trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21659725 chr3:3221576 CRBN 0.45 11.31 0.41 3.64e-27 Intelligence (multi-trait analysis); BRCA cis rs7809950 0.678 rs79902674 chr7:106866498 A/C cg23024343 chr7:107201750 COG5 -0.44 -8.84 -0.33 9.51e-18 Coronary artery disease; BRCA cis rs2153535 0.580 rs4365970 chr6:8453813 C/T cg21535247 chr6:8435926 SLC35B3 -0.4 -9.04 -0.34 1.82e-18 Motion sickness; BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg04267008 chr7:1944627 MAD1L1 -0.51 -11.11 -0.4 2.45e-26 Bipolar disorder and schizophrenia; BRCA cis rs2070488 0.766 rs4679050 chr3:38482007 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.72 0.57 1.83e-57 Electrocardiographic conduction measures; BRCA trans rs9858542 0.953 rs9818590 chr3:49525096 A/G cg21659725 chr3:3221576 CRBN -0.46 -9.91 -0.36 1.27e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg11062466 chr8:58055876 NA 0.5 8.75 0.33 1.83e-17 Developmental language disorder (linguistic errors); BRCA cis rs4742903 0.904 rs10991167 chr9:106974382 C/T cg14250997 chr9:106856677 SMC2 -0.3 -9.39 -0.35 1.02e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7809950 0.954 rs2894466 chr7:107242909 G/A cg23024343 chr7:107201750 COG5 0.42 9.18 0.34 5.8e-19 Coronary artery disease; BRCA cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg05279229 chr7:1896384 MAD1L1 -0.41 -7.85 -0.3 1.73e-14 Bipolar disorder and schizophrenia; BRCA cis rs757110 0.834 rs1002226 chr11:17405617 C/T cg04705435 chr11:17411270 KCNJ11 0.38 8.17 0.31 1.71e-15 Type 2 diabetes; BRCA cis rs5167 0.504 rs7246900 chr19:45454236 G/A cg13119609 chr19:45449297 APOC2 0.47 12.99 0.46 2e-34 Blood protein levels; BRCA cis rs6582630 0.519 rs1607882 chr12:38361657 G/A cg13010199 chr12:38710504 ALG10B 0.42 8.83 0.33 9.68e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs7727544 0.582 rs2301579 chr5:131553340 C/A cg14196790 chr5:131705035 SLC22A5 0.35 8.98 0.33 3.07e-18 Blood metabolite levels; BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg12444411 chr7:2802554 GNA12 -0.35 -8.37 -0.31 3.56e-16 Height; BRCA cis rs6964587 1.000 rs6969536 chr7:91689351 C/G cg01689657 chr7:91764605 CYP51A1 0.22 8.01 0.3 5.39e-15 Breast cancer; BRCA cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg01939980 chr4:1354348 KIAA1530 0.36 9.9 0.36 1.32e-21 Longevity; BRCA cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg19920283 chr7:105172520 RINT1 0.61 9.53 0.35 3.16e-20 Bipolar disorder (body mass index interaction); BRCA cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.3 -0.31 6.13e-16 Monocyte percentage of white cells; BRCA cis rs17253792 0.822 rs78522049 chr14:56071203 A/C cg01858014 chr14:56050164 KTN1 -0.78 -11.08 -0.4 3.12e-26 Putamen volume; BRCA cis rs875971 1.000 rs7801282 chr7:65613687 C/T cg11764359 chr7:65958608 NA -0.79 -19.5 -0.61 8.84e-67 Aortic root size; BRCA trans rs2204008 0.515 rs11495471 chr12:38027178 G/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.55e-21 Bladder cancer; BRCA cis rs1904096 0.506 rs4558832 chr4:95148042 G/A cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.1 -0.37 2.47e-22 Type 2 diabetes; BRCA trans rs61931739 0.500 rs7298322 chr12:34445489 A/T cg26384229 chr12:38710491 ALG10B 0.57 13.16 0.46 3.66e-35 Morning vs. evening chronotype; BRCA cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg04450456 chr4:17643702 FAM184B 0.42 12.73 0.45 3.07e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs41005 0.967 rs193928 chr2:8107899 T/C cg03155496 chr2:8117019 LOC339788 0.56 14.78 0.5 1e-42 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs600806 0.778 rs1525916 chr1:110010949 A/G cg20591472 chr1:110008990 SYPL2 0.31 7.91 0.3 1.1e-14 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg01877450 chr7:97915802 BRI3 -0.38 -8.49 -0.32 1.47e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs6964587 1.000 rs28927678 chr7:91715662 C/T cg01689657 chr7:91764605 CYP51A1 0.23 8.09 0.3 2.92e-15 Breast cancer; BRCA cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -8.49 -0.32 1.46e-16 Breast cancer; BRCA cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg13628971 chr7:2884303 GNA12 0.55 12.38 0.44 1.07e-31 Height; BRCA cis rs9527 0.590 rs7074395 chr10:104844928 A/C cg04362960 chr10:104952993 NT5C2 -0.44 -9.95 -0.37 8.45e-22 Arsenic metabolism; BRCA cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.36 -8.14 -0.31 2.08e-15 High light scatter reticulocyte count; BRCA cis rs7524258 0.835 rs7521425 chr1:7306543 C/T cg07173049 chr1:7289937 CAMTA1 0.41 9.9 0.36 1.41e-21 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs1949733 0.656 rs2688224 chr4:8404700 C/G cg11789530 chr4:8429930 ACOX3 0.59 14.87 0.51 3.54e-43 Response to antineoplastic agents; BRCA cis rs7647973 1.000 rs13322887 chr3:49555583 G/A cg07636037 chr3:49044803 WDR6 -0.71 -15.29 -0.52 3.47e-45 Menarche (age at onset); BRCA cis rs2075371 0.863 rs1646635 chr7:134006728 T/C cg02659138 chr7:134003124 SLC35B4 0.36 11.23 0.41 7.6e-27 Mean platelet volume; BRCA cis rs72781680 0.611 rs55905755 chr2:24330264 T/C cg08917208 chr2:24149416 ATAD2B 0.55 8.44 0.32 2.15e-16 Lymphocyte counts; BRCA cis rs1949733 1.000 rs3103072 chr4:8508431 C/T cg13073564 chr4:8508604 NA 0.45 12.28 0.44 2.8e-31 Response to antineoplastic agents; BRCA cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg12011299 chr4:100065546 ADH4 -0.49 -11.63 -0.42 1.76e-28 Alcohol dependence; BRCA cis rs4363385 0.720 rs1415968 chr1:152970219 C/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.88 -0.33 6.69e-18 Inflammatory skin disease; BRCA trans rs6479891 1.000 rs61853336 chr10:64899875 G/A cg14819942 chr15:35414228 NA 0.35 8.58 0.32 7.14e-17 Arthritis (juvenile idiopathic); BRCA trans rs9650657 0.655 rs1991651 chr8:10706411 C/G cg06636001 chr8:8085503 FLJ10661 0.42 8.57 0.32 7.71e-17 Neuroticism; BRCA cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg00852783 chr1:26633632 UBXN11 0.5 10.82 0.39 3.46e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs4845875 0.564 rs2151655 chr1:11845518 G/C cg24844545 chr1:11908347 NPPA 0.36 8.42 0.32 2.49e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg21573476 chr21:45109991 RRP1B 0.37 9.36 0.35 1.39e-19 Mean corpuscular volume; BRCA cis rs1401999 0.966 rs2313216 chr3:183637251 C/T cg01324343 chr3:183735012 ABCC5 0.77 19.16 0.6 5.28e-65 Anterior chamber depth; BRCA cis rs881375 0.934 rs2159778 chr9:123678129 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 10.5 0.38 6.54e-24 Rheumatoid arthritis; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17376456 0.825 rs17314797 chr5:93234845 T/A cg21475434 chr5:93447410 FAM172A 0.67 8.62 0.32 5.45e-17 Diabetic retinopathy; BRCA cis rs1044826 0.553 rs295469 chr3:139212900 G/A cg00490450 chr3:139108681 COPB2 0.43 8.28 0.31 7.14e-16 Obesity-related traits; BRCA cis rs4363385 0.791 rs4041401 chr1:152985629 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.42 -0.32 2.39e-16 Inflammatory skin disease; BRCA cis rs514406 0.698 rs567880 chr1:53348564 T/G cg16325326 chr1:53192061 ZYG11B 0.53 11.66 0.42 1.34e-28 Monocyte count; BRCA cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg06212747 chr3:49208901 KLHDC8B -0.46 -9.29 -0.35 2.3e-19 Menarche (age at onset); BRCA cis rs2625529 0.818 rs16956241 chr15:72111688 G/T cg16672083 chr15:72433130 SENP8 -0.8 -16.28 -0.54 4.18e-50 Red blood cell count; BRCA cis rs7178424 0.742 rs12911564 chr15:62211976 G/A cg00456672 chr15:62358751 C2CD4A 0.38 9.35 0.35 1.5e-19 Height; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.72 0.42 7.23e-29 Tonsillectomy; BRCA cis rs4664304 0.620 rs11675122 chr2:160713446 C/A cg14819504 chr2:160761413 LY75 0.34 8.26 0.31 8.28e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg15212455 chr7:39170539 POU6F2 0.39 8.6 0.32 6.16e-17 IgG glycosylation; BRCA cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg20203395 chr5:56204925 C5orf35 0.63 12.44 0.44 5.79e-32 Initial pursuit acceleration; BRCA cis rs7520050 0.966 rs61102033 chr1:46382441 G/T cg24296786 chr1:45957014 TESK2 0.43 9.74 0.36 5.25e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7567389 0.740 rs4536600 chr2:128002572 A/G cg09760422 chr2:128146352 NA 0.39 8.5 0.32 1.3e-16 Self-rated health; BRCA cis rs6066835 1.000 rs6125439 chr20:47314634 G/A cg18078177 chr20:47281410 PREX1 0.69 8.04 0.3 4.27e-15 Multiple myeloma; BRCA cis rs9527 0.590 rs12415199 chr10:104895536 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs7552404 0.628 rs4949686 chr1:76473299 G/C cg22875332 chr1:76189707 ACADM 0.57 9.68 0.36 9.28e-21 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs11039798 1.000 rs10838918 chr11:48507449 A/G cg15704280 chr7:45808275 SEPT13 0.57 8.44 0.32 2.16e-16 Axial length; BRCA cis rs10189230 0.967 rs12613015 chr2:222356119 G/A cg14652038 chr2:222343519 EPHA4 0.47 13.06 0.46 9.99e-35 Urate levels in lean individuals; BRCA trans rs11722228 0.522 rs73212817 chr4:10064011 T/C cg26043149 chr18:55253948 FECH 1.04 21.65 0.65 2.17e-78 Gout;Urate levels;Serum uric acid levels; BRCA cis rs6809651 0.524 rs4686730 chr3:185805993 C/T cg00760338 chr3:185826511 ETV5 -0.49 -10.03 -0.37 4.36e-22 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs1997103 0.906 rs4618644 chr7:55402037 T/G cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg07917127 chr4:99064746 C4orf37 0.42 8.01 0.3 5.26e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg03676636 chr4:99064102 C4orf37 0.21 7.97 0.3 7.55e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6840360 0.615 rs1561916 chr4:152479234 C/T cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 5.82e-15 Intelligence (multi-trait analysis); BRCA cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg15556689 chr8:8085844 FLJ10661 -0.36 -9.84 -0.36 2.27e-21 Mood instability; BRCA cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.21 -0.34 4.57e-19 Alzheimer's disease (late onset); BRCA cis rs2777491 1.000 rs7167729 chr15:41721042 G/A cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.03 -0.54 7.19e-49 Ulcerative colitis; BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.86 0.6 2.15e-63 Alzheimer's disease; BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.88 0.33 6.7e-18 Platelet count; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg05457628 chr5:178986728 RUFY1 -0.53 -13.46 -0.47 1.59e-36 Lung cancer; BRCA trans rs2018683 0.649 rs221171 chr7:29006139 C/G cg19402173 chr7:128379420 CALU 0.37 8.03 0.3 4.59e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6901250 0.788 rs591794 chr6:117089018 G/A cg12892004 chr6:117198278 RFX6 0.46 10.66 0.39 1.57e-24 C-reactive protein levels; BRCA cis rs490234 0.966 rs530628 chr9:128325934 C/G cg14078157 chr9:128172775 NA -0.33 -8.0 -0.3 5.82e-15 Mean arterial pressure; BRCA cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg05340658 chr4:99064831 C4orf37 0.53 8.75 0.33 1.91e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.915 rs10773208 chr12:122970156 T/C cg23029597 chr12:123009494 RSRC2 -0.63 -12.61 -0.45 1.06e-32 Body mass index; BRCA cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg10802521 chr3:52805072 NEK4 -0.34 -9.36 -0.35 1.29e-19 Bipolar disorder; BRCA cis rs796364 1.000 rs796364 chr2:200716119 C/A cg23649088 chr2:200775458 C2orf69 0.6 9.09 0.34 1.21e-18 Schizophrenia; BRCA cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg06671706 chr8:8559999 CLDN23 0.45 8.77 0.33 1.57e-17 Obesity-related traits; BRCA cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 8.02 0.3 4.98e-15 Mean platelet volume; BRCA cis rs2243480 0.901 rs35087093 chr7:65405208 C/T cg18252515 chr7:66147081 NA -0.84 -12.12 -0.43 1.34e-30 Diabetic kidney disease; BRCA cis rs9814567 1.000 rs62269547 chr3:134214042 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12541635 0.966 rs56352125 chr8:107041831 G/T cg10147462 chr8:107024639 NA 0.37 9.72 0.36 6.3e-21 Age of smoking initiation; BRCA cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg11266682 chr4:10021025 SLC2A9 0.39 10.39 0.38 1.88e-23 Bone mineral density; BRCA cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2880765 0.566 rs17553790 chr15:86013665 C/T cg10818794 chr15:86012489 AKAP13 0.4 10.88 0.4 2.13e-25 Coronary artery disease; BRCA cis rs2839186 0.900 rs56840278 chr21:47708933 T/G cg12379764 chr21:47803548 PCNT -0.37 -7.84 -0.3 1.84e-14 Testicular germ cell tumor; BRCA cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.03 -0.34 1.94e-18 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.542 rs17083380 chr5:93170476 C/G cg25358565 chr5:93447407 FAM172A -0.46 -8.28 -0.31 7.35e-16 Diabetic retinopathy; BRCA cis rs832540 0.669 rs173764 chr5:56198920 C/T cg18230493 chr5:56204884 C5orf35 -0.56 -11.87 -0.43 1.66e-29 Coronary artery disease; BRCA trans rs4650994 0.525 rs4650997 chr1:178530744 T/A cg05059571 chr16:84539110 KIAA1609 -0.57 -12.54 -0.44 1.99e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs832540 0.669 rs832539 chr5:56199386 A/C cg18230493 chr5:56204884 C5orf35 -0.55 -11.74 -0.42 6.1e-29 Coronary artery disease; BRCA cis rs6066825 0.605 rs761273 chr20:47315488 A/G cg18078177 chr20:47281410 PREX1 0.41 10.15 0.37 1.57e-22 Colorectal cancer; BRCA trans rs11662586 0.517 rs7228070 chr18:77698967 C/T cg05926928 chr17:57297772 GDPD1 0.42 8.22 0.31 1.13e-15 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs9309473 0.606 rs78941213 chr2:73885137 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -7.91 -0.3 1.18e-14 Metabolite levels; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.06 -0.49 2.43e-39 Platelet count; BRCA cis rs9467773 0.565 rs6925047 chr6:26521435 C/G cg11502198 chr6:26597334 ABT1 0.61 11.56 0.42 3.36e-28 Intelligence (multi-trait analysis); BRCA cis rs2797160 0.935 rs926855 chr6:126021782 A/G cg05901451 chr6:126070800 HEY2 0.4 9.68 0.36 9.01e-21 Endometrial cancer; BRCA trans rs61931739 0.571 rs4001689 chr12:34243271 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.57 0.35 2.33e-20 Morning vs. evening chronotype; BRCA cis rs7662987 0.517 rs2602881 chr4:100040695 A/G cg13256891 chr4:100009986 ADH5 0.52 9.74 0.36 5.31e-21 Smoking initiation; BRCA cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.13 -0.31 2.3e-15 Blood pressure (smoking interaction); BRCA cis rs3733585 0.775 rs13124007 chr4:10043931 G/C cg00071950 chr4:10020882 SLC2A9 0.55 13.19 0.46 2.62e-35 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7598759 0.548 rs1823328 chr2:232355184 G/A cg19187155 chr2:232395269 NMUR1 0.7 16.77 0.55 1.42e-52 Noise-induced hearing loss; BRCA trans rs7980799 0.935 rs10844580 chr12:33553867 G/A cg26384229 chr12:38710491 ALG10B -0.39 -8.18 -0.31 1.51e-15 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs4243830 0.737 rs6692747 chr1:6610049 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 0.94 14.53 0.5 1.5e-41 Body mass index; BRCA cis rs9549367 0.826 rs2302755 chr13:113898418 C/T cg00898013 chr13:113819073 PROZ -0.35 -8.92 -0.33 4.96e-18 Platelet distribution width; BRCA cis rs2832077 0.506 rs2832081 chr21:30152992 A/C cg24692254 chr21:30365293 RNF160 0.46 10.19 0.37 1.07e-22 Cognitive test performance; BRCA cis rs35306767 0.855 rs61830931 chr10:932497 T/C cg26597838 chr10:835615 NA 1.29 21.15 0.64 1.22e-75 Eosinophil percentage of granulocytes; BRCA cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.29 -0.35 2.31e-19 Electroencephalogram traits; BRCA trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg17788362 chr6:86352627 SYNCRIP 0.39 7.94 0.3 9.07e-15 Smooth-surface caries; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.25 -0.44 3.71e-31 Alzheimer's disease; BRCA cis rs7662987 0.517 rs1453874 chr4:100022724 G/A cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Smoking initiation; BRCA cis rs13191362 0.872 rs36069443 chr6:163248701 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.64 9.67 0.36 9.73e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs28374715 0.662 rs691907 chr15:41474657 C/G cg18705301 chr15:41695430 NDUFAF1 0.78 16.62 0.55 7.6900000000000007e-52 Ulcerative colitis; BRCA cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg02659138 chr7:134003124 SLC35B4 0.34 10.79 0.39 4.94e-25 Mean platelet volume; BRCA trans rs2832077 0.943 rs4816332 chr21:30201706 T/C cg14791747 chr16:20752902 THUMPD1 0.4 9.31 0.35 2.11e-19 Cognitive test performance; BRCA cis rs9309473 0.948 rs11884776 chr2:73746923 C/T cg20560298 chr2:73613845 ALMS1 -0.44 -10.92 -0.4 1.43e-25 Metabolite levels; BRCA cis rs12545109 0.765 rs2610047 chr8:57412106 T/C cg09654669 chr8:57350985 NA -0.38 -8.34 -0.31 4.55e-16 Obesity-related traits; BRCA cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg16006841 chr5:176797999 RGS14 0.58 11.57 0.42 3.09e-28 Hemoglobin concentration;Hematocrit; BRCA trans rs3733585 0.781 rs6449183 chr4:9970691 C/A cg26043149 chr18:55253948 FECH -0.41 -9.06 -0.34 1.52e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs78456975 0.739 rs11891867 chr2:1517894 C/T cg12573674 chr2:1569213 NA -0.49 -9.56 -0.35 2.53e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9790314 0.502 rs7647118 chr3:161016165 T/C cg03342759 chr3:160939853 NMD3 -0.79 -18.47 -0.59 2.41e-61 Morning vs. evening chronotype; BRCA cis rs5758659 0.652 rs133324 chr22:42406371 C/A cg15557168 chr22:42548783 NA -0.31 -8.58 -0.32 7.15e-17 Cognitive function; BRCA cis rs936229 0.651 rs12908814 chr15:75132490 C/G cg14664628 chr15:75095509 CSK -0.59 -14.47 -0.5 3.03e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7829975 0.539 rs940031 chr8:8546848 C/T cg06636001 chr8:8085503 FLJ10661 -0.42 -8.51 -0.32 1.29e-16 Mood instability; BRCA cis rs1005277 0.541 rs2263163 chr10:38389887 G/A cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs1829883 0.835 rs2460664 chr5:98802442 C/T cg08333243 chr5:99726346 NA -0.35 -7.81 -0.3 2.39e-14 Hemostatic factors and hematological phenotypes; BRCA cis rs4074536 0.574 rs10754354 chr1:116292402 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 4.94e-17 QRS duration; BRCA trans rs6582630 0.502 rs11522899 chr12:38270637 T/C cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs701145 0.585 rs1624917 chr3:153827300 T/A cg12800244 chr3:153838788 SGEF 0.63 7.87 0.3 1.47e-14 Coronary artery disease; BRCA cis rs7598759 0.712 rs6727372 chr2:232331906 T/G cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.08e-14 Noise-induced hearing loss; BRCA trans rs3733585 0.577 rs5014939 chr4:9953253 T/A cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg05623727 chr3:50126028 RBM5 0.44 10.43 0.38 1.22e-23 Intelligence (multi-trait analysis); BRCA cis rs11792861 0.888 rs57314245 chr9:111813832 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.47 9.63 0.36 1.39e-20 Menarche (age at onset); BRCA cis rs875971 0.522 rs781144 chr7:65440344 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.43 9.9 0.36 1.38e-21 Aortic root size; BRCA cis rs4803468 0.967 rs4605279 chr19:41888131 C/G cg09537434 chr19:41945824 ATP5SL -0.96 -23.21 -0.68 6.54e-87 Height; BRCA cis rs17125944 0.505 rs77949716 chr14:53204234 G/A cg00686598 chr14:53173677 PSMC6 1.25 16.37 0.54 1.43e-50 Alzheimer's disease (late onset); BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg22800045 chr5:56110881 MAP3K1 0.67 12.89 0.45 5.7e-34 Initial pursuit acceleration; BRCA cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg11845111 chr2:191398756 TMEM194B 0.41 9.23 0.34 3.9e-19 Pulse pressure; BRCA cis rs3733585 0.578 rs6837224 chr4:9955255 G/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.68e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11719291 0.833 rs13074318 chr3:48816725 C/T cg01304814 chr3:48885189 PRKAR2A 0.7 7.91 0.3 1.13e-14 Cognitive function; BRCA trans rs617791 0.678 rs551659 chr11:65749645 C/T cg17712092 chr4:129076599 LARP1B 0.56 13.38 0.47 3.54e-36 Breast cancer; BRCA cis rs919433 0.679 rs10203581 chr2:198515900 G/A cg00792783 chr2:198669748 PLCL1 0.4 9.0 0.34 2.59e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs3936840 0.565 rs8006911 chr14:102975265 A/G cg18135206 chr14:102964638 TECPR2 0.53 10.87 0.39 2.34e-25 Plateletcrit; BRCA cis rs6952809 0.532 rs10272548 chr7:2439467 G/A cg05083358 chr7:2394359 EIF3B -0.51 -8.0 -0.3 5.66e-15 Multiple sclerosis; BRCA cis rs6061231 1.000 rs67941642 chr20:60958108 C/T cg22601191 chr20:60968625 CABLES2 0.34 8.61 0.32 5.52e-17 Colorectal cancer; BRCA cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs2153535 0.580 rs4960422 chr6:8459309 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs6121246 0.697 rs6060446 chr20:30231637 T/C cg13852791 chr20:30311386 BCL2L1 0.79 14.87 0.51 3.55e-43 Mean corpuscular hemoglobin; BRCA cis rs724568 0.546 rs10188512 chr2:67940962 C/T cg14046302 chr2:67939758 NA -0.39 -10.68 -0.39 1.3e-24 Major depressive disorder (broad); BRCA cis rs4906332 0.811 rs2756138 chr14:103996733 C/G cg19000871 chr14:103996768 TRMT61A 0.47 10.55 0.39 4.13e-24 Coronary artery disease; BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.98 18.07 0.58 2.92e-59 Platelet count; BRCA cis rs55665837 0.559 rs11023209 chr11:14422600 T/C cg19336497 chr11:14380999 RRAS2 -0.44 -11.75 -0.42 5.16e-29 Vitamin D levels; BRCA cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.48 10.27 0.38 5.32e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7267979 0.966 rs2145126 chr20:25263648 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.840 rs2814867 chr6:146334030 C/A cg23711669 chr6:146136114 FBXO30 0.71 16.36 0.54 1.66e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs6942407 0.546 rs765968 chr7:86794724 G/A cg02420886 chr7:86849541 C7orf23 0.52 7.81 0.3 2.31e-14 Food allergy; BRCA cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg27170947 chr2:26402098 FAM59B -0.7 -11.84 -0.42 2.14e-29 Gut microbiome composition (summer); BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.73 16.44 0.55 6.19e-51 Lymphocyte counts; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg18402987 chr7:1209562 NA 0.84 12.05 0.43 2.92e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6964587 1.000 rs2888851 chr7:91648341 G/A cg17063962 chr7:91808500 NA 0.53 12.48 0.44 3.84e-32 Breast cancer; BRCA cis rs9807989 0.507 rs2287033 chr2:103011237 C/T cg03938978 chr2:103052716 IL18RAP -0.29 -8.4 -0.32 2.89e-16 Asthma; BRCA cis rs155076 0.938 rs261375 chr13:21871882 A/G cg25811766 chr13:21894605 NA 0.59 9.22 0.34 4.15e-19 White matter hyperintensity burden; BRCA cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg13770153 chr20:60521292 NA -0.42 -9.35 -0.35 1.43e-19 Body mass index; BRCA cis rs17401966 0.838 rs11579365 chr1:10470846 G/T cg19773385 chr1:10388646 KIF1B -0.37 -7.98 -0.3 6.94e-15 Hepatocellular carcinoma; BRCA cis rs7572733 0.534 rs700667 chr2:198677508 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.22 0.37 8.54e-23 Dermatomyositis; BRCA cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg01884057 chr2:25150051 NA 0.31 8.31 0.31 5.61e-16 Body mass index in non-asthmatics; BRCA cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.16e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs12497850 0.931 rs6442130 chr3:48778027 A/G cg06212747 chr3:49208901 KLHDC8B 0.42 8.19 0.31 1.4e-15 Parkinson's disease; BRCA cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.72 -0.42 7.49e-29 Uric acid levels; BRCA cis rs6840258 1.000 rs55787557 chr4:87950825 A/G cg08197287 chr4:87952173 AFF1 -0.44 -8.8 -0.33 1.25e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs13046373 0.535 rs13051135 chr21:32005278 G/A cg16812893 chr21:31813075 KRTAP15-1 0.38 9.55 0.35 2.76e-20 HDL cholesterol; BRCA cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 12.18 0.43 7.79e-31 Personality dimensions; BRCA cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg02221750 chr19:17393354 ANKLE1 -0.66 -12.83 -0.45 1.07e-33 Systemic lupus erythematosus; BRCA cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg05347473 chr6:146136440 FBXO30 0.4 8.11 0.31 2.64e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs877529 0.967 rs139400 chr22:39545396 C/T cg18708252 chr22:39545030 CBX7 -0.31 -7.93 -0.3 9.74e-15 Multiple myeloma; BRCA cis rs796364 0.616 rs2689765 chr2:200696352 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.54 8.35 0.31 4.1e-16 Schizophrenia; BRCA cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg15556689 chr8:8085844 FLJ10661 -0.4 -11.39 -0.41 1.64e-27 Mood instability; BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.3e-19 Tonsillectomy; BRCA cis rs11098499 0.909 rs28793658 chr4:120307214 A/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg19748678 chr4:122722346 EXOSC9 0.65 14.23 0.49 4.05e-40 Type 2 diabetes; BRCA cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg05707623 chr12:122985044 ZCCHC8 -0.52 -10.31 -0.38 3.56e-23 Body mass index; BRCA cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg18876405 chr7:65276391 NA 0.62 15.21 0.52 8.2e-45 Aortic root size; BRCA cis rs7617773 0.817 rs11928691 chr3:48286765 C/T cg11946769 chr3:48343235 NME6 0.55 12.13 0.43 1.34e-30 Coronary artery disease; BRCA cis rs11711311 1.000 rs2305545 chr3:113499733 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.2 -0.37 9.64e-23 IgG glycosylation; BRCA cis rs72615157 0.539 rs12673441 chr7:99670328 A/T cg22004693 chr7:99632812 ZKSCAN1 0.53 11.49 0.41 6.53e-28 Lung function (FEV1/FVC); BRCA cis rs12493885 0.697 rs11710478 chr3:153777037 A/C cg17054900 chr3:154042577 DHX36 -0.5 -8.64 -0.32 4.44e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2180341 1.000 rs7756336 chr6:127650299 T/C cg24812749 chr6:127587940 RNF146 0.88 20.59 0.63 1.27e-72 Breast cancer; BRCA cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg02175503 chr12:58329896 NA 0.61 14.45 0.5 3.63e-41 Intelligence (multi-trait analysis); BRCA cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg12386194 chr3:101231763 SENP7 0.44 8.99 0.34 2.72e-18 Colorectal cancer; BRCA cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg26384229 chr12:38710491 ALG10B 0.81 20.39 0.63 1.5e-71 Heart rate; BRCA cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg02556042 chr12:117471086 NA -0.58 -9.81 -0.36 2.97e-21 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs4919694 0.572 rs72846714 chr10:104878454 G/A cg04362960 chr10:104952993 NT5C2 0.73 12.72 0.45 3.27e-33 Arsenic metabolism; BRCA cis rs875971 0.862 rs778734 chr7:65814849 C/G cg18876405 chr7:65276391 NA 0.51 11.56 0.42 3.27e-28 Aortic root size; BRCA cis rs7772486 0.754 rs6570703 chr6:145957052 C/T cg23711669 chr6:146136114 FBXO30 0.71 17.04 0.56 6.13e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs208520 0.690 rs6929762 chr6:66709277 C/T cg07460842 chr6:66804631 NA 0.97 19.45 0.61 1.52e-66 Exhaled nitric oxide output; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg05552183 chr6:42928497 GNMT 0.8 19.34 0.61 6.32e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg25767906 chr1:53392781 SCP2 -0.37 -8.24 -0.31 9.99e-16 Monocyte count; BRCA cis rs11098499 0.866 rs12510451 chr4:120289143 C/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs11608355 0.515 rs56244055 chr12:109936211 G/A cg05360138 chr12:110035743 NA 0.72 13.3 0.47 8.56e-36 Neuroticism; BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg04944784 chr2:26401820 FAM59B -0.71 -11.69 -0.42 9.71e-29 Gut microbiome composition (summer); BRCA cis rs4363385 0.747 rs4568784 chr1:152972694 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -9.24 -0.34 3.72e-19 Inflammatory skin disease; BRCA cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg25173405 chr17:45401733 C17orf57 0.49 9.94 0.37 9.42e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg07952391 chr2:88470173 THNSL2 -0.4 -8.02 -0.3 5.12e-15 Response to metformin (IC50); BRCA cis rs921968 0.619 rs1554623 chr2:219606177 C/T cg02176678 chr2:219576539 TTLL4 -0.42 -11.16 -0.4 1.59e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs10870270 0.830 rs11146269 chr10:133761820 G/A cg17892150 chr10:133769511 PPP2R2D -0.73 -15.59 -0.52 1.17e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1003719 1.000 rs1003719 chr21:38491095 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.12 0.49 1.38e-39 Eye color traits; BRCA cis rs6429082 0.967 rs704710 chr1:235621026 A/G cg26050004 chr1:235667680 B3GALNT2 0.39 9.58 0.35 2.08e-20 Adiposity; BRCA cis rs2522056 1.000 rs1003533 chr5:131755651 C/T cg24060327 chr5:131705240 SLC22A5 0.5 8.73 0.33 2.21e-17 Lymphocyte counts;Fibrinogen; BRCA cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA trans rs7824557 0.767 rs17797443 chr8:11164012 T/C cg15556689 chr8:8085844 FLJ10661 0.37 8.74 0.33 2.04e-17 Retinal vascular caliber; BRCA cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg07423050 chr13:99094983 FARP1 0.5 12.35 0.44 1.46e-31 Neuroticism; BRCA trans rs11098499 0.644 rs34835603 chr4:120553428 C/T cg25214090 chr10:38739885 LOC399744 0.44 10.01 0.37 5.38e-22 Corneal astigmatism; BRCA trans rs17685 0.712 rs6953342 chr7:75776753 T/C cg19862616 chr7:65841803 NCRNA00174 0.82 26.58 0.72 2.01e-105 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg18964960 chr10:1102726 WDR37 0.53 8.9 0.33 5.93e-18 Response to angiotensin II receptor blocker therapy; BRCA cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs2243480 1.000 rs35735127 chr7:65300423 G/T cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg23711669 chr6:146136114 FBXO30 0.77 17.59 0.57 8.37e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs3008870 1.000 rs3008858 chr1:67390416 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.74 0.65 7.41e-79 Lymphocyte percentage of white cells; BRCA cis rs7666738 0.830 rs34070283 chr4:98893027 A/T cg05340658 chr4:99064831 C4orf37 0.62 14.72 0.5 1.88e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 0.966 rs3002698 chr20:25303379 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.66 -0.32 3.74e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs9291683 0.704 rs11726271 chr4:10098192 G/A cg26043149 chr18:55253948 FECH -0.37 -8.2 -0.31 1.35e-15 Bone mineral density; BRCA cis rs477692 0.905 rs570967 chr10:131421330 T/G cg05714579 chr10:131428358 MGMT 0.57 14.08 0.49 2.03e-39 Response to temozolomide; BRCA cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.79e-68 Blood protein levels; BRCA cis rs67460515 0.892 rs4856703 chr3:161047720 G/T cg03342759 chr3:160939853 NMD3 -0.8 -18.87 -0.6 1.83e-63 Parkinson's disease; BRCA cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg23029597 chr12:123009494 RSRC2 0.59 11.42 0.41 1.35e-27 Body mass index; BRCA cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg20203395 chr5:56204925 C5orf35 0.41 9.18 0.34 5.91e-19 Initial pursuit acceleration; BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg26516362 chr5:178986906 RUFY1 0.44 12.47 0.44 4.14e-32 Lung cancer; BRCA cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg13854012 chr2:162103682 NA -0.39 -8.68 -0.32 3.33e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs870825 0.616 rs4264873 chr4:185624336 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg24006582 chr15:45444508 DUOX1 0.54 10.62 0.39 2.17e-24 Uric acid levels; BRCA cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.68e-18 Motion sickness; BRCA cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg03146154 chr1:46216737 IPP 0.51 11.12 0.4 2.18e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4800452 0.956 rs4239436 chr18:20731930 A/G cg26136497 chr18:20735537 CABLES1 -0.48 -11.55 -0.42 3.66e-28 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs7264396 0.635 rs6060660 chr20:34476649 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.69 -14.37 -0.49 8.98e-41 Total cholesterol levels; BRCA cis rs332507 0.830 rs13069961 chr3:124358715 A/G cg05980111 chr3:124395277 KALRN 0.36 8.23 0.31 1.09e-15 Plateletcrit; BRCA cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -9.66 -0.36 1.07e-20 Schizophrenia; BRCA cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg11584989 chr19:19387371 SF4 -0.59 -13.22 -0.46 1.98e-35 Bipolar disorder; BRCA trans rs236907 0.812 rs55732843 chr1:171796962 A/G cg13482142 chr2:234261155 NA 0.51 8.03 0.3 4.68e-15 Mean platelet volume; BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg01262667 chr19:19385393 TM6SF2 0.42 10.87 0.39 2.35e-25 Tonsillectomy; BRCA cis rs34779708 0.733 rs4244997 chr10:35547254 T/C cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg14863265 chr7:2801509 GNA12 -0.42 -9.69 -0.36 8.48e-21 Height; BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.49 -9.1 -0.34 1.09e-18 Gut microbiome composition (summer); BRCA cis rs2742540 0.505 rs2742493 chr11:8967592 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.31 7.9 0.3 1.24e-14 Hematocrit; BRCA cis rs367943 0.698 rs728915 chr5:112995748 C/T cg12552261 chr5:112820674 MCC 0.45 9.45 0.35 6.4e-20 Type 2 diabetes; BRCA cis rs116095464 0.558 rs55833259 chr5:286728 G/A cg22496380 chr5:211416 CCDC127 -1.0 -14.08 -0.49 1.99e-39 Breast cancer; BRCA cis rs10911232 0.507 rs2151669 chr1:183055398 T/G ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.73e-54 Hypertriglyceridemia; BRCA cis rs6580649 0.941 rs4760618 chr12:48434767 G/A cg24011408 chr12:48396354 COL2A1 -0.48 -7.93 -0.3 9.92e-15 Lung cancer; BRCA cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg23422044 chr7:1970798 MAD1L1 -0.56 -9.6 -0.35 1.85e-20 Neuroticism; BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.72 -13.8 -0.48 4.19e-38 Alzheimer's disease; BRCA cis rs561341 0.783 rs512698 chr17:30292507 G/T cg00745463 chr17:30367425 LRRC37B -0.53 -8.93 -0.33 4.38e-18 Hip circumference adjusted for BMI; BRCA cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg08601574 chr20:25228251 PYGB -0.35 -8.36 -0.31 3.88e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -14.73 -0.5 1.73e-42 Initial pursuit acceleration; BRCA cis rs9533799 1.000 rs2282064 chr13:44805870 G/A cg19190762 chr13:44806055 NA 0.4 8.77 0.33 1.56e-17 Amyotrophic lateral sclerosis; BRCA cis rs2066819 0.786 rs116934693 chr12:56696545 T/G cg26714650 chr12:56694279 CS -1.18 -15.46 -0.52 5.14e-46 Psoriasis vulgaris; BRCA cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg04450456 chr4:17643702 FAM184B 0.31 9.08 0.34 1.37e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10876993 0.893 rs4760168 chr12:58087737 T/G cg18357645 chr12:58087776 OS9 0.49 13.85 0.48 2.58e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs17270561 0.609 rs1892254 chr6:25750530 T/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.74 0.33 2.11e-17 Iron status biomarkers; BRCA cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 12.53 0.44 2.22e-32 Calcium levels; BRCA cis rs922182 0.556 rs10851734 chr15:64216247 C/T cg24729988 chr15:64271149 DAPK2 -0.45 -9.35 -0.35 1.43e-19 Blood protein levels; BRCA cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02018176 chr4:1364513 KIAA1530 0.4 8.29 0.31 6.87e-16 Longevity; BRCA cis rs4853036 0.723 rs2312557 chr2:70090243 G/A cg02498382 chr2:70120550 SNRNP27 -0.54 -8.76 -0.33 1.77e-17 Colorectal or endometrial cancer; BRCA cis rs79057730 0.599 rs9458 chr7:825494 A/G cg11064039 chr7:766100 PRKAR1B;HEATR2 -0.72 -10.3 -0.38 4.11e-23 Initial pursuit acceleration; BRCA cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg16339924 chr4:17578868 LAP3 0.63 15.73 0.53 2.26e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9880211 1.000 rs17364492 chr3:136204437 G/T cg21827317 chr3:136751795 NA 0.42 7.82 0.3 2.2e-14 Body mass index;Height; BRCA cis rs6834538 0.965 rs1580476 chr4:113493365 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.38 8.41 0.32 2.66e-16 Free thyroxine concentration; BRCA cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg25019033 chr10:957182 NA -0.41 -7.82 -0.3 2.16e-14 Eosinophil percentage of granulocytes; BRCA cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg12310025 chr6:25882481 NA 0.44 9.7 0.36 7.52e-21 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg11814155 chr7:99998594 ZCWPW1 0.46 8.22 0.31 1.16e-15 Platelet count; BRCA cis rs2404602 0.735 rs12903874 chr15:76693318 A/T cg23625390 chr15:77176239 SCAPER -0.52 -12.72 -0.45 3.52e-33 Blood metabolite levels; BRCA cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.69 0.5 2.56e-42 Colorectal cancer; BRCA cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg03264133 chr6:25882463 NA 0.43 10.21 0.37 9.03e-23 Blood metabolite levels; BRCA cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.46 -9.39 -0.35 1e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs6138458 1.000 rs227631 chr20:24913653 A/G cg26195577 chr20:24973756 C20orf3 0.98 24.67 0.7 6.47e-95 Blood protein levels; BRCA cis rs62458065 0.513 rs787220 chr7:32581139 C/G cg20159608 chr7:32802032 NA -0.5 -9.64 -0.36 1.25e-20 Metabolite levels (HVA/MHPG ratio); BRCA cis rs4319547 1.000 rs10998 chr12:122989412 G/A cg23029597 chr12:123009494 RSRC2 -0.64 -12.64 -0.45 7.38e-33 Body mass index; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg10729496 chr3:10149963 C3orf24 0.48 9.11 0.34 1.02e-18 Alzheimer's disease; BRCA cis rs4363385 0.747 rs1415970 chr1:152965741 G/C cg25856811 chr1:152973957 SPRR3 -0.35 -9.44 -0.35 7.12e-20 Inflammatory skin disease; BRCA cis rs7772486 0.521 rs9485017 chr6:146023326 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.06 0.49 2.66e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs9325144 0.647 rs12424190 chr12:39111206 A/T cg26384229 chr12:38710491 ALG10B -0.47 -11.05 -0.4 4.34e-26 Morning vs. evening chronotype; BRCA cis rs2387326 0.717 rs12261194 chr10:129944464 T/C cg16087940 chr10:129947807 NA -0.45 -8.01 -0.3 5.47e-15 Select biomarker traits; BRCA cis rs6912958 0.712 rs6454641 chr6:88371060 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.41 -0.32 2.59e-16 Monocyte percentage of white cells; BRCA cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4363385 0.747 rs1999886 chr1:152955522 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.29 -0.34 2.43e-19 Inflammatory skin disease; BRCA cis rs4820539 1.000 rs4822358 chr22:23474795 A/G cg14186256 chr22:23484241 RTDR1 0.8 24.94 0.7 2.24e-96 Bone mineral density; BRCA cis rs546131 0.928 rs516228 chr11:34838823 C/T cg06937548 chr11:34938143 PDHX;APIP 0.43 8.2 0.31 1.33e-15 Lung disease severity in cystic fibrosis; BRCA cis rs7666738 0.515 rs13434650 chr4:98889886 A/G cg05340658 chr4:99064831 C4orf37 0.55 10.81 0.39 3.79e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs67981189 0.865 rs2810071 chr14:71387648 A/G cg15816911 chr14:71606274 NA -0.37 -8.28 -0.31 7.17e-16 Schizophrenia; BRCA cis rs561341 1.000 rs111454793 chr17:30319267 T/C cg00745463 chr17:30367425 LRRC37B -0.54 -8.89 -0.33 6.17e-18 Hip circumference adjusted for BMI; BRCA cis rs2832191 0.967 rs3787660 chr21:30520907 C/T cg08807101 chr21:30365312 RNF160 0.53 13.2 0.46 2.43e-35 Dental caries; BRCA cis rs362296 0.661 rs3095079 chr4:3265414 A/G cg06533319 chr4:3265114 C4orf44 -0.29 -7.83 -0.3 2e-14 Parental longevity (mother's age at death); BRCA cis rs10193935 0.901 rs2374429 chr2:42677888 A/G cg27598129 chr2:42591480 NA -0.81 -13.87 -0.48 1.89e-38 Colonoscopy-negative controls vs population controls; BRCA cis rs853679 0.513 rs9468296 chr6:28113730 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.06 -0.3 3.79e-15 Depression; BRCA trans rs7618501 1.000 rs6446295 chr3:49809063 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.54 16.96 0.56 1.6e-53 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg16482183 chr6:26056742 HIST1H1C 0.65 13.49 0.47 1.08e-36 Height; BRCA cis rs11190604 1.000 rs2495751 chr10:102327260 A/G cg07080220 chr10:102295463 HIF1AN 0.57 13.04 0.46 1.19e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA trans rs3780486 0.846 rs6476399 chr9:33123013 A/G cg20290983 chr6:43655470 MRPS18A 1.12 41.25 0.85 2.53e-182 IgG glycosylation; BRCA cis rs11711311 1.000 rs9288984 chr3:113525956 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.44 0.32 2.15e-16 IgG glycosylation; BRCA cis rs66887589 0.616 rs11732621 chr4:120212883 A/C cg09307838 chr4:120376055 NA 0.46 9.57 0.35 2.25e-20 Diastolic blood pressure; BRCA cis rs2070488 0.965 rs13093640 chr3:38487176 A/G cg24069376 chr3:38537580 EXOG 0.42 12.17 0.43 8.73e-31 Electrocardiographic conduction measures; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg16606324 chr3:10149918 C3orf24 0.56 11.15 0.4 1.74e-26 Alzheimer's disease; BRCA cis rs13427251 0.868 rs1901284 chr2:100146040 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.52 12.6 0.45 1.14e-32 Chronic sinus infection; BRCA cis rs10464366 0.912 rs2030960 chr7:39106010 G/A cg15212455 chr7:39170539 POU6F2 0.36 7.87 0.3 1.48e-14 IgG glycosylation; BRCA cis rs9487051 0.768 rs463916 chr6:109520538 A/G cg21918786 chr6:109611834 NA -0.34 -9.15 -0.34 7.44e-19 Reticulocyte fraction of red cells; BRCA trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21659725 chr3:3221576 CRBN -0.48 -10.56 -0.39 3.87e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs270601 0.837 rs367805 chr5:131701279 T/C cg24060327 chr5:131705240 SLC22A5 -0.6 -11.6 -0.42 2.24e-28 Acylcarnitine levels; BRCA cis rs7312933 0.932 rs10880220 chr12:42383046 A/G cg01256987 chr12:42539512 GXYLT1 -0.55 -11.05 -0.4 4.45e-26 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg09658497 chr7:2847517 GNA12 -0.39 -8.37 -0.31 3.78e-16 Height; BRCA cis rs7666738 0.800 rs10028921 chr4:98962630 G/T cg17366294 chr4:99064904 C4orf37 0.44 10.4 0.38 1.6e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs739496 0.542 rs7399113 chr12:111792848 G/A cg10833066 chr12:111807467 FAM109A 0.35 8.1 0.31 2.77e-15 Platelet count; BRCA cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg22431228 chr1:16359049 CLCNKA -0.45 -9.26 -0.34 2.96e-19 Dilated cardiomyopathy; BRCA cis rs9467773 0.565 rs4343916 chr6:26522675 A/T cg09904177 chr6:26538194 HMGN4 0.46 12.7 0.45 4.02e-33 Intelligence (multi-trait analysis); BRCA cis rs1113500 0.897 rs10785832 chr1:108638899 G/A cg06207961 chr1:108661230 NA 0.44 10.82 0.39 3.75e-25 Growth-regulated protein alpha levels; BRCA cis rs290268 0.874 rs290995 chr9:93559477 C/A cg02608019 chr9:93564028 SYK 0.55 12.28 0.44 2.92e-31 Platelet count; BRCA cis rs2762353 0.603 rs12201071 chr6:25778055 C/T cg12310025 chr6:25882481 NA 0.4 9.06 0.34 1.62e-18 Blood metabolite levels; BRCA cis rs427394 0.659 rs175594 chr5:6729885 T/G cg10857441 chr5:6722123 POLS -0.31 -9.91 -0.37 1.23e-21 Menopause (age at onset); BRCA cis rs9467711 0.606 rs13190739 chr6:26587373 G/T cg12826209 chr6:26865740 GUSBL1 0.73 7.8 0.3 2.44e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs13088645 0.683 rs9790169 chr3:134151959 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.4 -11.98 -0.43 5.41e-30 Coronary artery disease; BRCA cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg24110177 chr3:50126178 RBM5 0.52 15.17 0.51 1.34e-44 Intelligence (multi-trait analysis); BRCA cis rs12618769 0.652 rs3203856 chr2:99226021 C/T cg10123293 chr2:99228465 UNC50 0.44 8.7 0.33 2.71e-17 Bipolar disorder; BRCA trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg23533926 chr12:111358616 MYL2 -0.44 -9.18 -0.34 5.78e-19 Extrinsic epigenetic age acceleration; BRCA cis rs59698941 0.550 rs11748737 chr5:132201070 C/T cg14825688 chr5:132208181 LEAP2 -0.38 -8.79 -0.33 1.36e-17 Apolipoprotein A-IV levels; BRCA cis rs10739663 0.520 rs3122935 chr9:128154203 A/G cg14078157 chr9:128172775 NA 0.42 10.05 0.37 3.67e-22 Resting heart rate; BRCA trans rs35110281 0.627 rs7283362 chr21:44973667 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.82 0.33 1.06e-17 Mean corpuscular volume; BRCA cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg26647111 chr11:31128758 NA -0.4 -8.97 -0.33 3.14e-18 Red blood cell count; BRCA cis rs796364 0.951 rs11897245 chr2:201063644 A/G cg23649088 chr2:200775458 C2orf69 0.62 10.74 0.39 7.2e-25 Schizophrenia; BRCA cis rs7640424 0.620 rs17231503 chr3:107817299 C/T cg09227934 chr3:107805635 CD47 -0.43 -8.3 -0.31 6.39e-16 Body mass index; BRCA cis rs2370759 1.000 rs16933225 chr10:32599464 C/T cg01819863 chr10:32635814 EPC1 1.09 19.55 0.61 4.83e-67 Sexual dysfunction (female); BRCA cis rs10782582 0.593 rs17585530 chr1:76134990 G/A cg03433033 chr1:76189801 ACADM -0.47 -8.93 -0.33 4.61e-18 Daytime sleep phenotypes; BRCA cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.39e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6815814 0.851 rs11466645 chr4:38778203 A/T cg06935464 chr4:38784597 TLR10 0.47 7.83 0.3 2e-14 Breast cancer; BRCA cis rs2839186 0.500 rs13052701 chr21:47660045 A/T cg09417038 chr21:47716443 C21orf57 -0.32 -7.98 -0.3 6.57e-15 Testicular germ cell tumor; BRCA cis rs2806561 0.929 rs641452 chr1:23538386 A/G cg12483005 chr1:23474871 LUZP1 0.37 7.96 0.3 7.82e-15 Height; BRCA cis rs13272623 0.502 rs268601 chr8:71518548 C/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.47 -9.94 -0.37 9.3e-22 IgG glycosylation; BRCA cis rs7580658 0.509 rs12477653 chr2:127952081 C/T cg16751203 chr2:127950803 CYP27C1 0.28 8.19 0.31 1.44e-15 Protein C levels; BRCA cis rs698833 0.926 rs698835 chr2:44737089 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.73 0.36 5.71e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs72627509 0.951 rs72627508 chr4:57831564 C/G cg26694713 chr4:57773883 REST 0.45 8.03 0.3 4.56e-15 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs1448094 0.621 rs7133309 chr12:86284078 T/C cg19622623 chr12:86230825 RASSF9 -0.29 -8.29 -0.31 6.91e-16 Major depressive disorder; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18758796 chr5:131593413 PDLIM4 0.37 9.02 0.34 2.19e-18 Acylcarnitine levels; BRCA cis rs6910061 1.000 rs10080950 chr6:11116467 T/G cg27233058 chr6:11094804 LOC221710 0.53 9.43 0.35 7.64e-20 Diabetic kidney disease; BRCA cis rs17376456 0.569 rs6556839 chr5:93206292 T/C cg25358565 chr5:93447407 FAM172A -0.65 -11.2 -0.41 1.04e-26 Diabetic retinopathy; BRCA cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg17420585 chr12:42539391 GXYLT1 -0.38 -8.02 -0.3 5.08e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6543140 0.964 rs7561351 chr2:103077780 A/G cg04239558 chr2:103089729 SLC9A4 0.34 9.6 0.36 1.72e-20 Blood protein levels; BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg05793240 chr7:2802953 GNA12 -0.34 -8.7 -0.33 2.82e-17 Height; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg22907277 chr7:1156413 C7orf50 0.65 12.75 0.45 2.52e-33 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1451375 1.000 rs1451374 chr7:50622653 G/A cg18232548 chr7:50535776 DDC 0.44 10.19 0.37 1.09e-22 Malaria; BRCA cis rs243505 0.528 rs740951 chr7:148470160 C/A cg09806900 chr7:148480153 CUL1 0.54 11.32 0.41 3.41e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs765787 0.530 rs11070444 chr15:45513121 T/C cg25801113 chr15:45476975 SHF -0.33 -8.31 -0.31 5.63e-16 Uric acid levels; BRCA cis rs77106637 0.932 rs17244499 chr11:72629946 C/T cg03713592 chr11:72463424 ARAP1 -0.72 -10.76 -0.39 6.39e-25 Type 2 diabetes; BRCA trans rs1325195 0.881 rs2791941 chr1:179112435 G/A cg11624085 chr17:8464688 MYH10 0.26 8.14 0.31 2e-15 IgE grass sensitization; BRCA cis rs2235642 0.893 rs2143285 chr16:1593171 A/G cg09065629 chr16:1709722 CRAMP1L 0.35 8.1 0.31 2.84e-15 Coronary artery disease; BRCA cis rs775227 0.574 rs34049435 chr3:113099499 C/T cg18753928 chr3:113234510 CCDC52 -0.58 -9.5 -0.35 4.02e-20 Dental caries; BRCA cis rs473651 0.935 rs474478 chr2:239335473 C/T cg18131467 chr2:239335373 ASB1 0.96 35.03 0.81 7.62e-151 Multiple system atrophy; BRCA cis rs61931739 0.534 rs2636082 chr12:34061848 T/A cg06521331 chr12:34319734 NA -0.63 -12.16 -0.43 9.6e-31 Morning vs. evening chronotype; BRCA trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.3 8.01 0.3 5.61e-15 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.697 rs6088856 chr20:30226543 C/G cg21427119 chr20:30132790 HM13 -0.43 -8.94 -0.33 4.11e-18 Mean corpuscular hemoglobin; BRCA cis rs9463078 0.547 rs116177834 chr6:44738548 C/A cg25276700 chr6:44698697 NA 0.35 8.05 0.3 4.19e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs34375054 0.660 rs900411 chr12:125612839 C/T cg25124228 chr12:125621409 AACS -0.43 -8.9 -0.33 5.94e-18 Post bronchodilator FEV1/FVC ratio; BRCA trans rs12310956 0.532 rs7306007 chr12:33975209 C/G cg26384229 chr12:38710491 ALG10B 0.52 11.2 0.41 1e-26 Morning vs. evening chronotype; BRCA trans rs2008242 0.593 rs985222 chr4:5229884 A/G cg26099876 chr8:141644609 EIF2C2 -0.38 -9.59 -0.35 2.01e-20 Electrocardiographic conduction measures; BRCA cis rs727479 0.502 rs28757202 chr15:51503881 T/A cg19946085 chr15:51559439 CYP19A1 -0.3 -8.4 -0.32 2.97e-16 Estradiol levels; BRCA cis rs11677370 0.561 rs4849990 chr2:3819558 A/G cg17052675 chr2:3827356 NA -0.57 -13.92 -0.48 1.14e-38 Type 2 diabetes; BRCA cis rs2070433 0.948 rs2839304 chr21:47952650 C/G cg12379764 chr21:47803548 PCNT -0.53 -9.83 -0.36 2.46e-21 Lymphocyte counts; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg09436375 chr6:42928200 GNMT -0.3 -11.01 -0.4 6.3e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs10911363 0.615 rs12024309 chr1:183419981 A/G cg09173681 chr1:183549694 NCF2 -0.52 -10.99 -0.4 7.23e-26 Systemic lupus erythematosus; BRCA cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg08601574 chr20:25228251 PYGB -0.34 -8.24 -0.31 9.76e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.55 0.35 2.61e-20 Height; BRCA cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg13319975 chr6:146136371 FBXO30 -0.44 -10.11 -0.37 2.1e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg00083206 chr6:110721305 DDO -0.4 -9.67 -0.36 1.01e-20 Platelet distribution width; BRCA cis rs965469 0.947 rs56689368 chr20:3332921 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -10.5 -0.38 6.58e-24 IFN-related cytopenia; BRCA cis rs10193935 0.786 rs13416119 chr2:42462930 A/G cg27598129 chr2:42591480 NA -1.03 -11.7 -0.42 8.5e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 0.932 rs4280527 chr20:25544014 A/G cg08601574 chr20:25228251 PYGB 0.34 8.27 0.31 7.69e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs854765 0.647 rs854769 chr17:18019011 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.47 -12.84 -0.45 9.97e-34 Total body bone mineral density; BRCA cis rs220324 0.688 rs11701681 chr21:43564274 A/G cg09727148 chr21:43560719 UMODL1 0.43 7.88 0.3 1.38e-14 Idiopathic osteonecrosis of the femoral head; BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13126279 chr21:47581558 C21orf56 -0.5 -10.88 -0.4 2.03e-25 Testicular germ cell tumor; BRCA cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.18 -0.54 1.37e-49 Alzheimer's disease (late onset); BRCA cis rs7937890 1.000 rs2970334 chr11:14329355 C/T cg19336497 chr11:14380999 RRAS2 0.3 8.04 0.3 4.29e-15 Mitochondrial DNA levels; BRCA cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.39 8.46 0.32 1.82e-16 Aortic root size; BRCA trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg25214090 chr10:38739885 LOC399744 0.54 12.25 0.44 3.83e-31 Corneal astigmatism; BRCA cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs932287 0.540 rs4910442 chr11:9044337 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.59 12.32 0.44 1.96e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 0.609 rs1317510 chr6:25778924 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.73e-20 Iron status biomarkers; BRCA cis rs2839186 0.900 rs2839196 chr21:47708037 G/A cg13126279 chr21:47581558 C21orf56 -0.4 -8.44 -0.32 2.1e-16 Testicular germ cell tumor; BRCA trans rs6582630 0.502 rs12815350 chr12:38439921 A/T cg06521331 chr12:34319734 NA -0.43 -7.82 -0.3 2.16e-14 Drug-induced liver injury (flucloxacillin); BRCA cis rs921968 0.541 rs526897 chr2:219433597 C/T cg10223061 chr2:219282414 VIL1 -0.27 -8.01 -0.3 5.56e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6088580 0.608 rs1205342 chr20:32921842 C/T cg08999081 chr20:33150536 PIGU -0.45 -12.33 -0.44 1.72e-31 Glomerular filtration rate (creatinine); BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.37 -8.11 -0.31 2.51e-15 Tonsillectomy; BRCA cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg00074818 chr8:8560427 CLDN23 0.38 8.3 0.31 6.14e-16 Obesity-related traits; BRCA trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg23533926 chr12:111358616 MYL2 -0.43 -8.89 -0.33 6.36e-18 Extrinsic epigenetic age acceleration; BRCA cis rs1371614 0.531 rs77562583 chr2:27151643 G/A cg12368169 chr2:27073192 DPYSL5 0.28 8.24 0.31 9.55e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9658691 0.607 rs9325604 chr10:90775756 A/G cg03111039 chr10:90751583 FAS;ACTA2 -0.56 -8.17 -0.31 1.7e-15 Mosquito bite size; BRCA cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg04518342 chr5:131593106 PDLIM4 0.33 8.21 0.31 1.21e-15 Blood metabolite levels; BRCA cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs1448094 0.512 rs61930861 chr12:86245023 G/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.28 -0.34 2.49e-19 Major depressive disorder; BRCA cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg27121462 chr16:89883253 FANCA -0.44 -9.84 -0.36 2.25e-21 Vitiligo; BRCA cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg10295955 chr4:187884368 NA -0.99 -32.04 -0.79 4.48e-135 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.715 rs11514342 chr12:38236710 T/A cg13010199 chr12:38710504 ALG10B 0.44 8.87 0.33 7.18e-18 Bladder cancer; BRCA cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg10295955 chr4:187884368 NA -0.99 -31.64 -0.78 6.55e-133 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg08601574 chr20:25228251 PYGB 0.34 8.04 0.3 4.28e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs16866061 0.515 rs3738951 chr2:225368321 A/G cg12698349 chr2:225449008 CUL3 0.84 29.39 0.76 8.89e-121 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs40363 0.723 rs757269 chr16:3538003 A/G cg22508957 chr16:3507546 NAT15 -0.55 -9.01 -0.34 2.41e-18 Tuberculosis; BRCA cis rs12541635 0.967 rs13256474 chr8:107086419 T/C cg10147462 chr8:107024639 NA -0.3 -8.25 -0.31 9.29e-16 Age of smoking initiation; BRCA cis rs7249921 0.833 rs59975720 chr19:35660954 G/A cg15419183 chr19:35660584 FXYD5 0.45 10.04 0.37 3.97e-22 Platelet count; BRCA cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg26031613 chr14:104095156 KLC1 0.44 8.77 0.33 1.57e-17 Schizophrenia; BRCA cis rs826838 0.967 rs12823908 chr12:38845686 T/C cg13010199 chr12:38710504 ALG10B 0.56 12.22 0.44 5.11e-31 Heart rate; BRCA cis rs752010 0.875 rs11210501 chr1:42091634 T/C cg06885757 chr1:42089581 HIVEP3 0.24 8.66 0.32 3.9e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs708547 0.647 rs1718839 chr4:57827206 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.37 9.51 0.35 3.67e-20 Response to bleomycin (chromatid breaks); BRCA cis rs2404602 0.684 rs1603860 chr15:76849591 A/T cg23625390 chr15:77176239 SCAPER -0.54 -13.65 -0.48 1.99e-37 Blood metabolite levels; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.69 -12.98 -0.46 2.21e-34 Alzheimer's disease; BRCA cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.62 -0.32 5.38e-17 Monocyte percentage of white cells; BRCA cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg08213375 chr14:104286397 PPP1R13B -0.64 -18.4 -0.59 5.36e-61 Schizophrenia; BRCA cis rs17604090 0.529 rs2392128 chr7:29711139 A/G cg19413766 chr7:29689036 LOC646762 0.56 9.08 0.34 1.36e-18 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg11764359 chr7:65958608 NA 0.62 13.64 0.47 2.29e-37 Calcium levels; BRCA cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA trans rs7726839 0.561 rs72703058 chr5:584519 G/A cg25482853 chr8:67687455 SGK3 0.79 13.2 0.46 2.48e-35 Obesity-related traits; BRCA cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg26695010 chr11:65641043 EFEMP2 0.38 8.45 0.32 2.04e-16 Eosinophil percentage of white cells; BRCA cis rs10927875 0.541 rs1048334 chr1:16340761 T/C cg06159980 chr1:16340746 HSPB7 -0.38 -8.8 -0.33 1.27e-17 Dilated cardiomyopathy; BRCA cis rs17601876 0.807 rs12910259 chr15:51555049 G/A cg19946085 chr15:51559439 CYP19A1 -0.38 -11.11 -0.4 2.54e-26 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs801193 0.548 rs2109297 chr7:66122384 G/A cg18876405 chr7:65276391 NA -0.49 -10.77 -0.39 5.79e-25 Aortic root size; BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.38 -8.86 -0.33 7.8e-18 Tonsillectomy; BRCA cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg24060327 chr5:131705240 SLC22A5 -0.63 -12.27 -0.44 3.2e-31 Breast cancer; BRCA trans rs6598955 0.671 rs6658935 chr1:26568912 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs1371867 0.846 rs1788203 chr8:101303721 T/C cg06636551 chr8:101224915 SPAG1 -0.38 -8.66 -0.32 3.83e-17 Atrioventricular conduction; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg27588902 chr6:42928151 GNMT -0.31 -10.16 -0.37 1.45e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs514406 0.505 rs436363 chr1:53172163 T/C cg24675658 chr1:53192096 ZYG11B -0.61 -14.11 -0.49 1.48e-39 Monocyte count; BRCA cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg18876405 chr7:65276391 NA 0.63 15.45 0.52 5.37e-46 Aortic root size; BRCA cis rs16866061 1.000 rs1568750 chr2:225342597 A/T cg12698349 chr2:225449008 CUL3 0.77 21.11 0.64 1.92e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg07636037 chr3:49044803 WDR6 0.56 9.16 0.34 7.19e-19 Menarche (age at onset); BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.33e-19 Tonsillectomy; BRCA cis rs6684514 0.885 rs12036837 chr1:156283895 A/C cg16558208 chr1:156270281 VHLL 0.34 7.87 0.3 1.5e-14 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA trans rs877282 0.853 rs7069720 chr10:754487 A/G cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs477692 0.792 rs12762024 chr10:131441055 G/C cg05714579 chr10:131428358 MGMT -0.55 -13.28 -0.47 9.78e-36 Response to temozolomide; BRCA cis rs881375 0.967 rs7034492 chr9:123687211 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.89 0.4 1.93e-25 Rheumatoid arthritis; BRCA trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg03929089 chr4:120376271 NA -0.69 -13.56 -0.47 5.16e-37 Coronary artery disease; BRCA cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg17971929 chr21:40555470 PSMG1 -0.47 -10.15 -0.37 1.59e-22 Menarche (age at onset); BRCA cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg01028140 chr2:1542097 TPO -0.8 -15.82 -0.53 8.12e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs11123694 1.000 rs11123694 chr2:109064563 C/T cg02082929 chr2:109068933 GCC2 0.41 12.17 0.43 8.42e-31 Mean platelet volume; BRCA cis rs7772486 0.686 rs1569540 chr6:146069112 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -16.98 -0.56 1.25e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 9.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs757110 0.745 rs10734252 chr11:17404839 G/A cg15432903 chr11:17409602 KCNJ11 0.72 15.82 0.53 7.83e-48 Type 2 diabetes; BRCA cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 12.1 0.43 1.72e-30 Mean platelet volume; BRCA cis rs4853036 0.904 rs12713683 chr2:70156321 G/A cg02498382 chr2:70120550 SNRNP27 -0.55 -10.77 -0.39 5.74e-25 Colorectal or endometrial cancer; BRCA cis rs2576037 0.583 rs545344 chr18:44367079 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.57 12.98 0.46 2.41e-34 Personality dimensions; BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg21724239 chr8:58056113 NA 0.57 9.3 0.35 2.24e-19 Developmental language disorder (linguistic errors); BRCA cis rs9296092 0.560 rs62407569 chr6:33538865 A/G cg13560919 chr6:33536144 NA -0.86 -17.74 -0.57 1.44e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7737355 0.947 rs6596027 chr5:130879547 A/G cg06307176 chr5:131281290 NA 0.53 10.55 0.39 4.12e-24 Life satisfaction; BRCA cis rs7617773 0.780 rs13082859 chr3:48344675 C/T cg11946769 chr3:48343235 NME6 0.68 13.86 0.48 2.24e-38 Coronary artery disease; BRCA cis rs9400271 0.632 rs9384706 chr6:109601504 C/T cg01475377 chr6:109611718 NA -0.43 -10.2 -0.37 1.01e-22 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs2832191 0.550 rs66484040 chr21:30511691 G/A cg08807101 chr21:30365312 RNF160 -0.44 -9.33 -0.35 1.66e-19 Dental caries; BRCA cis rs7582180 0.614 rs4149518 chr2:101013649 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.54 0.42 4.07e-28 Intelligence (multi-trait analysis); BRCA cis rs10045504 0.502 rs72746032 chr5:38743982 T/C cg15396434 chr5:38725168 NA -0.57 -11.06 -0.4 3.91e-26 Night sleep phenotypes; BRCA cis rs7949030 0.626 rs7124057 chr11:62334096 A/G cg11742103 chr11:62369870 EML3;MTA2 0.54 13.39 0.47 3.11e-36 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.73e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg19077165 chr18:44547161 KATNAL2 0.39 8.38 0.31 3.39e-16 Personality dimensions; BRCA cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.46 0.47 1.53e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10463316 0.894 rs3846712 chr5:150759813 C/A cg03212797 chr5:150827313 SLC36A1 -0.42 -8.08 -0.3 3.31e-15 Metabolite levels (Pyroglutamine); BRCA cis rs6912958 0.630 rs4707377 chr6:88280332 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg03709012 chr19:19516395 GATAD2A -0.79 -18.04 -0.58 4.11e-59 Tonsillectomy; BRCA cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.36 0.35 1.33e-19 Menopause (age at onset); BRCA cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg23442198 chr4:187126114 CYP4V2 0.92 10.72 0.39 8.98e-25 Blood protein levels; BRCA cis rs921968 0.565 rs7562426 chr2:219605118 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 6.11e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.5 11.12 0.4 2.24e-26 Multiple sclerosis; BRCA cis rs7618501 0.540 rs11130241 chr3:50131459 A/T cg05623727 chr3:50126028 RBM5 -0.42 -10.06 -0.37 3.32e-22 Intelligence (multi-trait analysis); BRCA cis rs2282802 0.685 rs12717951 chr5:139589309 A/G cg26211634 chr5:139558579 C5orf32 0.33 8.05 0.3 3.98e-15 Intelligence (multi-trait analysis); BRCA cis rs10128251 0.847 rs12777965 chr10:5724297 T/C cg24097872 chr10:5724021 NA -0.57 -12.34 -0.44 1.59e-31 Childhood ear infection; BRCA cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg05535760 chr7:792225 HEATR2 0.74 13.47 0.47 1.33e-36 Cerebrospinal P-tau181p levels; BRCA cis rs7020830 0.898 rs7038219 chr9:37182892 C/A cg14294708 chr9:37120828 ZCCHC7 1.06 32.19 0.79 7.47e-136 Schizophrenia; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg27588902 chr6:42928151 GNMT -0.3 -10.06 -0.37 3.51e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg22307029 chr19:49891270 CCDC155 0.55 9.96 0.37 8.16e-22 Multiple sclerosis; BRCA cis rs7772486 0.754 rs864148 chr6:145976675 T/C cg23711669 chr6:146136114 FBXO30 -0.78 -18.77 -0.6 5.83e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg08392591 chr16:89556376 ANKRD11 0.46 10.83 0.39 3.22e-25 Multiple myeloma (IgH translocation); BRCA trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg03929089 chr4:120376271 NA -0.47 -9.04 -0.34 1.9e-18 HDL cholesterol; BRCA cis rs7918232 0.782 rs7910168 chr10:27465296 G/A cg14240646 chr10:27532245 ACBD5 -0.62 -9.64 -0.36 1.26e-20 Breast cancer; BRCA cis rs12472274 0.646 rs2305171 chr2:239097140 G/A cg17459225 chr2:239074497 NA 0.57 9.71 0.36 7.16e-21 Phospholipid levels (plasma); BRCA trans rs3960554 0.674 rs112742093 chr7:75800597 T/C cg19862616 chr7:65841803 NCRNA00174 0.6 11.82 0.42 2.76e-29 Eotaxin levels; BRCA cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg05084668 chr3:125655381 ALG1L -0.47 -7.98 -0.3 6.69e-15 Blood pressure (smoking interaction); BRCA cis rs1577917 1.000 rs955196 chr6:86729951 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.49 13.0 0.46 1.8e-34 Response to antipsychotic treatment; BRCA cis rs27434 0.583 rs151908 chr5:96156494 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.73 -0.45 3.03e-33 Ankylosing spondylitis; BRCA cis rs5758659 0.652 rs133314 chr22:42401841 G/A cg15557168 chr22:42548783 NA -0.31 -8.66 -0.32 3.9e-17 Cognitive function; BRCA cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg25173405 chr17:45401733 C17orf57 -0.44 -8.93 -0.33 4.61e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10193935 0.901 rs72800020 chr2:42655615 A/G cg27598129 chr2:42591480 NA -0.87 -14.35 -0.49 1.13e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.12 0.4 2.21e-26 Bipolar disorder; BRCA cis rs67460515 0.500 rs9812507 chr3:160723393 G/A cg03342759 chr3:160939853 NMD3 -0.6 -11.99 -0.43 5.24e-30 Parkinson's disease; BRCA cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.34 -0.41 2.65e-27 Colorectal cancer; BRCA cis rs1008375 0.966 rs2286773 chr4:17616214 C/A cg15017067 chr4:17643749 FAM184B 0.32 9.92 0.37 1.16e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1669338 0.588 rs3846135 chr3:3195574 C/T cg16797762 chr3:3221439 CRBN -0.58 -9.11 -0.34 1.06e-18 White matter integrity; BRCA cis rs78456975 0.739 rs11891867 chr2:1517894 C/T cg01028140 chr2:1542097 TPO -0.71 -14.05 -0.49 2.86e-39 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9858542 0.953 rs11706370 chr3:49441091 G/A cg03060546 chr3:49711283 APEH -0.48 -9.63 -0.36 1.42e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9487051 0.768 rs1269172 chr6:109522080 G/C cg21918786 chr6:109611834 NA -0.35 -9.24 -0.34 3.73e-19 Reticulocyte fraction of red cells; BRCA cis rs1878931 0.535 rs10852706 chr16:3412582 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.48 8.53 0.32 1.09e-16 Body mass index (adult); BRCA cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24308560 chr3:49941425 MST1R -0.4 -8.6 -0.32 6.08e-17 Intelligence (multi-trait analysis); BRCA cis rs4662945 0.525 rs28819474 chr2:130264623 T/C cg05903289 chr2:130345205 NA -0.32 -8.08 -0.3 3.34e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs7647973 0.580 rs4955432 chr3:49266772 C/T cg06212747 chr3:49208901 KLHDC8B 0.54 11.64 0.42 1.55e-28 Menarche (age at onset); BRCA cis rs9815354 0.812 rs73071242 chr3:41993011 T/C cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs9318086 0.712 rs9510916 chr13:24442789 C/T cg25267304 chr13:24462978 PCOTH;MIPEP 0.32 8.96 0.33 3.57e-18 Myopia (pathological); BRCA cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg26597838 chr10:835615 NA 0.95 14.56 0.5 1.14e-41 Eosinophil percentage of granulocytes; BRCA trans rs11098499 0.866 rs11098506 chr4:120284971 A/G cg25214090 chr10:38739885 LOC399744 0.49 11.47 0.41 7.92e-28 Corneal astigmatism; BRCA cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg11301795 chr4:187892539 NA -0.3 -10.15 -0.37 1.54e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg27347728 chr4:17578864 LAP3 0.43 8.08 0.3 3.13e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7395581 0.918 rs1055510 chr11:47292237 A/G cg25783544 chr11:47291846 MADD 0.43 9.78 0.36 3.68e-21 HDL cholesterol; BRCA cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.67 0.36 9.68e-21 Bipolar disorder; BRCA cis rs2243480 1.000 rs431076 chr7:65600320 A/C cg18252515 chr7:66147081 NA -1.06 -15.58 -0.52 1.26e-46 Diabetic kidney disease; BRCA cis rs2625529 0.938 rs8747 chr15:72115541 C/A cg16672083 chr15:72433130 SENP8 -0.81 -16.58 -0.55 1.25e-51 Red blood cell count; BRCA cis rs7607369 0.648 rs7599984 chr2:219656713 T/G cg02176678 chr2:219576539 TTLL4 -0.47 -12.25 -0.44 4e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg13010199 chr12:38710504 ALG10B 0.58 12.89 0.45 6.06e-34 Heart rate; BRCA trans rs35110281 1.000 rs35110281 chr21:45068947 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.37 0.38 2.12e-23 Mean corpuscular volume; BRCA cis rs738321 0.762 rs5995543 chr22:38579026 G/A cg25457927 chr22:38595422 NA -0.39 -13.0 -0.46 1.85e-34 Breast cancer; BRCA cis rs6748734 1.000 rs4344931 chr2:241818527 A/C cg04034577 chr2:241836375 C2orf54 -0.55 -13.58 -0.47 4.49e-37 Urinary metabolites; BRCA cis rs2032447 0.736 rs115810 chr6:25975883 G/C cg12310025 chr6:25882481 NA -0.59 -12.72 -0.45 3.21e-33 Intelligence (multi-trait analysis); BRCA cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg14061069 chr19:46274453 DMPK -0.47 -11.82 -0.42 2.58e-29 Coronary artery disease; BRCA cis rs1568889 1.000 rs7934085 chr11:28369660 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.69 0.5 2.53e-42 Bipolar disorder; BRCA cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg16339924 chr4:17578868 LAP3 0.63 15.75 0.53 1.78e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.88 0.3 1.4e-14 Endometrial cancer; BRCA cis rs10838687 1.000 rs10838687 chr11:47312892 T/G cg25783544 chr11:47291846 MADD 0.42 8.49 0.32 1.48e-16 Proinsulin levels; BRCA cis rs1127311 0.846 rs61811388 chr1:154581231 G/C cg17218026 chr1:154582156 ADAR 0.29 8.59 0.32 6.52e-17 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg02475777 chr4:1388615 CRIPAK 0.56 11.13 0.4 1.96e-26 Longevity; BRCA cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg08847533 chr14:75593920 NEK9 -0.86 -21.94 -0.66 5.69e-80 Height; BRCA cis rs4363385 0.747 rs1415961 chr1:152973464 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.57 -0.35 2.23e-20 Inflammatory skin disease; BRCA cis rs17095355 1.000 rs7905306 chr10:111712902 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.1 -0.37 2.37e-22 Biliary atresia; BRCA cis rs870825 0.616 rs9715644 chr4:185632965 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg05283184 chr6:79620031 NA -0.43 -10.91 -0.4 1.61e-25 Intelligence (multi-trait analysis); BRCA cis rs801193 1.000 rs7782320 chr7:66177098 C/T cg18876405 chr7:65276391 NA 0.61 15.12 0.51 2.26e-44 Aortic root size; BRCA cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg09184832 chr6:79620586 NA -0.5 -10.82 -0.39 3.49e-25 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.909 rs57726761 chr20:30314046 A/G cg21427119 chr20:30132790 HM13 -0.42 -8.85 -0.33 8.37e-18 Mean corpuscular hemoglobin; BRCA cis rs11583043 1.000 rs6700743 chr1:101447384 A/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.4 8.02 0.3 5.01e-15 Ulcerative colitis;Inflammatory bowel disease; BRCA trans rs208520 0.802 rs4710314 chr6:66883656 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -18.36 -0.59 9.01e-61 Exhaled nitric oxide output; BRCA cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.618 rs10856932 chr4:98819992 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.71 0.5 2.04e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 0.935 rs7763118 chr6:162954720 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.77 11.32 0.41 3.19e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs8180040 0.726 rs11130110 chr3:47000606 T/C cg16586182 chr3:47516702 SCAP -0.53 -11.64 -0.42 1.57e-28 Colorectal cancer; BRCA cis rs7829975 0.572 rs7005000 chr8:8796602 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -11.95 -0.43 7.41e-30 Mood instability; BRCA cis rs9790314 1.000 rs189270 chr3:161063504 T/C cg03342759 chr3:160939853 NMD3 -0.65 -13.8 -0.48 4.28e-38 Morning vs. evening chronotype; BRCA cis rs17601876 0.843 rs6493494 chr15:51549835 G/A cg19946085 chr15:51559439 CYP19A1 -0.37 -10.71 -0.39 1e-24 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7520050 0.966 rs6675726 chr1:46560643 A/G cg24296786 chr1:45957014 TESK2 0.41 9.14 0.34 8.37e-19 Red blood cell count;Reticulocyte count; BRCA cis rs9443645 0.901 rs9443622 chr6:79582790 C/T cg11833968 chr6:79620685 NA -0.4 -8.9 -0.33 5.7e-18 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 10.58 0.39 3.23e-24 Aortic root size; BRCA trans rs11098499 0.863 rs7699064 chr4:120428309 A/G cg25214090 chr10:38739885 LOC399744 -0.55 -11.96 -0.43 6.58e-30 Corneal astigmatism; BRCA cis rs12701220 0.504 rs12702092 chr7:1145868 G/A cg00990874 chr7:1149470 C7orf50 -0.6 -11.81 -0.42 3.11e-29 Bronchopulmonary dysplasia; BRCA cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11644478 chr21:40555479 PSMG1 -0.66 -14.18 -0.49 7.33e-40 Cognitive function; BRCA cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg15595755 chr5:1867978 NA 0.35 8.35 0.31 4.19e-16 Cardiovascular disease risk factors; BRCA cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg15017067 chr4:17643749 FAM184B 0.26 7.87 0.3 1.5e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs16921914 0.559 rs2985140 chr11:31315886 C/T cg26647111 chr11:31128758 NA 0.45 9.8 0.36 3.31e-21 Bone mineral density (spine); BRCA cis rs35110281 0.548 rs7276316 chr21:45029333 A/T cg04455712 chr21:45112962 RRP1B 0.38 9.8 0.36 3.3e-21 Mean corpuscular volume; BRCA trans rs61931739 0.534 rs10844767 chr12:34152368 C/G cg13010199 chr12:38710504 ALG10B 0.49 9.64 0.36 1.23e-20 Morning vs. evening chronotype; BRCA cis rs16854884 0.632 rs1466941 chr3:143670131 A/G cg06585982 chr3:143692056 C3orf58 0.44 9.04 0.34 1.81e-18 Economic and political preferences (feminism/equality); BRCA cis rs1355223 0.545 rs12278318 chr11:34876507 C/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7481584 0.626 rs2071103 chr11:3040087 C/T cg25174290 chr11:3078921 CARS -0.3 -7.84 -0.3 1.86e-14 Calcium levels; BRCA trans rs12310956 0.510 rs10129020 chr12:33858936 T/G cg26384229 chr12:38710491 ALG10B 0.39 8.84 0.33 9.52e-18 Morning vs. evening chronotype; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg27170947 chr2:26402098 FAM59B 0.88 16.3 0.54 3.17e-50 Gut microbiome composition (summer); BRCA cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg13298116 chr11:62369859 EML3;MTA2 0.56 11.16 0.4 1.5e-26 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9463078 0.845 rs1023090 chr6:45012381 T/C cg25276700 chr6:44698697 NA -0.35 -7.98 -0.3 6.6e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.44 -8.4 -0.32 2.82e-16 Renal function-related traits (BUN); BRCA cis rs7618915 0.547 rs13064064 chr3:52657002 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.12 0.4 2.21e-26 Bipolar disorder; BRCA cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06544989 chr22:39130855 UNC84B 0.37 8.46 0.32 1.77e-16 Menopause (age at onset); BRCA cis rs6446731 0.517 rs2071668 chr4:3269905 A/G cg08886695 chr4:3369023 RGS12 0.37 9.87 0.36 1.82e-21 Mean platelet volume; BRCA trans rs6601327 0.602 rs7829463 chr8:9649691 C/G cg06636001 chr8:8085503 FLJ10661 -0.41 -8.33 -0.31 5.04e-16 Multiple myeloma (hyperdiploidy); BRCA cis rs3806933 0.500 rs10491423 chr5:110453977 C/A cg04022379 chr5:110408740 TSLP 0.47 10.11 0.37 2.11e-22 Eosinophilic esophagitis; BRCA cis rs11112613 0.595 rs871219 chr12:105938519 C/A cg03607813 chr12:105948248 NA 0.59 9.92 0.37 1.12e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg10819733 chr22:24237672 NA -0.29 -7.94 -0.3 9.15e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg13175981 chr1:150552382 MCL1 0.48 10.65 0.39 1.71e-24 Tonsillectomy; BRCA trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg22491629 chr6:157744540 C6orf35 -0.65 -11.56 -0.42 3.36e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg25019033 chr10:957182 NA -0.41 -7.99 -0.3 6.33e-15 Eosinophil percentage of granulocytes; BRCA trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg03929089 chr4:120376271 NA -0.45 -8.44 -0.32 2.2e-16 Height; BRCA cis rs17095355 1.000 rs734165 chr10:111697789 C/T cg00817464 chr10:111662876 XPNPEP1 -0.4 -8.68 -0.32 3.22e-17 Biliary atresia; BRCA trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg15704280 chr7:45808275 SEPT13 -0.57 -9.66 -0.36 1.04e-20 Axial length; BRCA cis rs61931739 0.534 rs4547187 chr12:34041259 T/C cg06521331 chr12:34319734 NA -0.58 -11.47 -0.41 7.88e-28 Morning vs. evening chronotype; BRCA trans rs61931739 0.534 rs11052960 chr12:33997754 A/T cg13010199 chr12:38710504 ALG10B 0.47 8.99 0.34 2.82e-18 Morning vs. evening chronotype; BRCA cis rs9790314 0.967 rs9821201 chr3:160996155 G/C cg03342759 chr3:160939853 NMD3 -0.63 -13.25 -0.46 1.38e-35 Morning vs. evening chronotype; BRCA trans rs2235573 0.527 rs139886 chr22:38371328 C/T cg19894588 chr14:64061835 NA 0.34 8.43 0.32 2.33e-16 Glioblastoma;Glioma; BRCA cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs6840360 0.593 rs1366907 chr4:152682749 T/C cg22705602 chr4:152727874 NA -0.38 -10.39 -0.38 1.81e-23 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs801204 chr7:66022921 T/C cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA cis rs7267979 1.000 rs6083844 chr20:25386832 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.79 -0.33 1.36e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg18876405 chr7:65276391 NA -0.62 -15.43 -0.52 6.52e-46 Aortic root size; BRCA cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.48 9.07 0.34 1.4e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3733585 0.631 rs4697924 chr4:10124239 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -9.08 -0.34 1.35e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2463822 0.858 rs2513077 chr11:62105925 A/G cg06239285 chr11:62104954 ASRGL1 -0.69 -11.7 -0.42 9.08e-29 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs9400271 0.632 rs949881 chr6:109586240 A/G cg01475377 chr6:109611718 NA -0.44 -10.66 -0.39 1.57e-24 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg04267008 chr7:1944627 MAD1L1 -0.59 -12.18 -0.43 7.81e-31 Schizophrenia; BRCA cis rs6665290 0.901 rs3795453 chr1:227205331 A/G cg10327440 chr1:227177885 CDC42BPA -1.11 -40.97 -0.85 6.13e-181 Myeloid white cell count; BRCA cis rs12468557 0.527 rs12694206 chr2:211499394 T/A cg07063745 chr2:211341572 LANCL1;CPS1 -0.36 -8.05 -0.3 4.12e-15 Body mass index in asthmatics; BRCA cis rs9420 0.884 rs644883 chr11:57663522 C/G cg19752551 chr11:57585705 CTNND1 0.48 12.38 0.44 1.04e-31 Schizophrenia; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 15.99 0.53 1.19e-48 Platelet count; BRCA trans rs7819412 0.645 rs10156356 chr8:11046209 T/C cg06636001 chr8:8085503 FLJ10661 -0.45 -9.09 -0.34 1.19e-18 Triglycerides; BRCA cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg26149184 chr10:133730230 NA 0.38 7.97 0.3 7.44e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg08564027 chr20:61660810 NA 0.85 22.96 0.67 1.66e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg24308560 chr3:49941425 MST1R -0.39 -8.3 -0.31 6.26e-16 Intelligence (multi-trait analysis); BRCA cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg26149184 chr10:133730230 NA 0.41 8.28 0.31 7.31e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg07148914 chr20:33460835 GGT7 -0.44 -9.44 -0.35 7.01e-20 Height; BRCA cis rs67478160 0.619 rs12897150 chr14:104319530 A/T cg08213375 chr14:104286397 PPP1R13B 0.64 17.63 0.57 5.71e-57 Schizophrenia; BRCA trans rs561341 0.769 rs12941700 chr17:30185022 A/G cg27661571 chr11:113659931 NA 0.57 8.08 0.3 3.21e-15 Hip circumference adjusted for BMI; BRCA cis rs36051895 0.588 rs12340895 chr9:5076691 C/G cg02405213 chr9:5042618 JAK2 0.52 9.48 0.35 4.87e-20 Pediatric autoimmune diseases; BRCA cis rs9649213 0.593 rs6967576 chr7:98016373 A/G cg01877450 chr7:97915802 BRI3 0.36 8.41 0.32 2.73e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs10464366 0.957 rs11765705 chr7:39106942 G/T cg15212455 chr7:39170539 POU6F2 0.36 7.87 0.3 1.48e-14 IgG glycosylation; BRCA cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg18200150 chr17:30822561 MYO1D 0.35 8.91 0.33 5.16e-18 Schizophrenia; BRCA cis rs2880765 0.835 rs7164106 chr15:86032590 T/C cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.27e-17 Coronary artery disease; BRCA cis rs3858526 0.959 rs10838795 chr11:5920721 A/G cg25319279 chr11:5960081 NA 0.41 8.18 0.31 1.55e-15 DNA methylation (variation); BRCA cis rs9462027 0.628 rs10947532 chr6:34780315 G/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.84 -0.3 1.96e-14 Systemic lupus erythematosus; BRCA cis rs1008375 0.900 rs10019460 chr4:17686337 T/C cg15017067 chr4:17643749 FAM184B -0.27 -8.17 -0.31 1.7e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8180040 0.966 rs1872164 chr3:47415100 G/A cg27129171 chr3:47204927 SETD2 -0.68 -16.16 -0.54 1.74e-49 Colorectal cancer; BRCA cis rs9649465 0.934 rs34030532 chr7:123274992 A/G cg04330084 chr7:123175371 IQUB -0.33 -8.98 -0.33 3.04e-18 Migraine; BRCA cis rs3806843 0.735 rs809635 chr5:140081791 A/G cg26395211 chr5:140044315 WDR55 0.37 8.58 0.32 7.32e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg23978390 chr7:1156363 C7orf50 0.51 11.97 0.43 6.04e-30 Longevity;Endometriosis; BRCA cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg20701182 chr2:24300061 SF3B14 0.71 13.07 0.46 9.61e-35 Lymphocyte counts; BRCA trans rs2018683 0.707 rs10279610 chr7:28975696 C/G cg19402173 chr7:128379420 CALU 0.41 9.87 0.36 1.74e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg08859206 chr1:53392774 SCP2 -0.49 -9.64 -0.36 1.24e-20 Monocyte count; BRCA cis rs5758511 0.633 rs5758690 chr22:42668295 C/G cg00645731 chr22:42541494 CYP2D7P1 0.51 10.04 0.37 4.16e-22 Birth weight; BRCA cis rs35110281 0.782 rs1584917 chr21:45042365 A/G cg04455712 chr21:45112962 RRP1B 0.42 11.0 0.4 6.95e-26 Mean corpuscular volume; BRCA trans rs1941687 0.505 rs8091920 chr18:31303557 C/G cg27147174 chr7:100797783 AP1S1 -0.41 -8.38 -0.31 3.37e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg19498844 chr21:46707878 POFUT2;LOC642852 -0.57 -12.2 -0.43 6.44e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11229555 0.645 rs7930547 chr11:58197616 A/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7786808 0.712 rs2335170 chr7:158207101 G/A cg01191920 chr7:158217561 PTPRN2 -0.36 -8.43 -0.32 2.32e-16 Obesity-related traits; BRCA cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg20887711 chr4:1340912 KIAA1530 -0.6 -12.95 -0.46 3.14e-34 Obesity-related traits; BRCA cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg13319975 chr6:146136371 FBXO30 0.34 8.0 0.3 5.98e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs813218 0.625 rs793484 chr3:99491508 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.86 -0.36 1.97e-21 Orofacial clefts; BRCA cis rs3812049 0.826 rs17764730 chr5:127357526 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.6 11.55 0.42 3.57e-28 Lymphocyte counts;Red cell distribution width; BRCA cis rs6089829 0.925 rs4809270 chr20:61676709 C/A cg02544614 chr20:61657117 NA 0.29 8.07 0.3 3.48e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg08061076 chr7:1943177 MAD1L1 -0.36 -8.22 -0.31 1.17e-15 Bipolar disorder and schizophrenia; BRCA cis rs9649213 0.593 rs6968144 chr7:97915697 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.62 0.45 8.93e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs17711722 0.565 rs4717276 chr7:65294741 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 12.26 0.44 3.63e-31 Calcium levels; BRCA cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg06453172 chr10:134556979 INPP5A -0.58 -11.54 -0.42 3.98e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg01689657 chr7:91764605 CYP51A1 -0.26 -9.19 -0.34 5.33e-19 Breast cancer; BRCA cis rs8017423 0.967 rs2401875 chr14:90688451 A/G cg04374321 chr14:90722782 PSMC1 0.72 18.59 0.59 5.19e-62 Mortality in heart failure; BRCA cis rs9287719 0.967 rs10191883 chr2:10744136 A/G cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs7590368 1.000 rs55968911 chr2:10961840 C/T cg15705551 chr2:10952987 PDIA6 0.44 8.09 0.3 3.12e-15 Educational attainment (years of education); BRCA cis rs2153535 0.504 rs4493781 chr6:8473941 G/C cg07606381 chr6:8435919 SLC35B3 0.64 14.18 0.49 7.18e-40 Motion sickness; BRCA cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.81 0.45 1.39e-33 Lung cancer in ever smokers; BRCA cis rs17604090 0.793 rs17150667 chr7:29689338 G/T cg19413766 chr7:29689036 LOC646762 -0.51 -8.2 -0.31 1.33e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs829883 0.659 rs12366950 chr12:98947900 T/C cg25150519 chr12:98850993 NA -0.49 -8.67 -0.32 3.56e-17 Colorectal adenoma (advanced); BRCA cis rs67478160 0.643 rs2295145 chr14:104202304 G/A cg01849466 chr14:104193079 ZFYVE21 -0.45 -11.56 -0.42 3.3e-28 Schizophrenia; BRCA cis rs1448094 0.511 rs7967183 chr12:86216845 T/G cg19622623 chr12:86230825 RASSF9 -0.32 -8.97 -0.33 3.31e-18 Major depressive disorder; BRCA cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg15017067 chr4:17643749 FAM184B 0.3 9.09 0.34 1.23e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3760982 0.585 rs10422108 chr19:44294868 C/T cg11993925 chr19:44307056 LYPD5 0.37 8.95 0.33 3.73e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg21782813 chr7:2030301 MAD1L1 0.36 9.11 0.34 1.06e-18 Bipolar disorder and schizophrenia; BRCA cis rs514406 0.505 rs269293 chr1:53187767 A/C cg24675658 chr1:53192096 ZYG11B -0.66 -14.3 -0.49 1.81e-40 Monocyte count; BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 18.52 0.59 1.22e-61 Platelet count; BRCA cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.09e-23 Motion sickness; BRCA cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg16743903 chr16:89593216 SPG7 -0.32 -7.94 -0.3 8.98e-15 Multiple myeloma (IgH translocation); BRCA trans rs61931739 0.517 rs10844830 chr12:34308133 C/T cg26384229 chr12:38710491 ALG10B 0.45 10.22 0.37 8.55e-23 Morning vs. evening chronotype; BRCA cis rs2066819 1.000 rs75754909 chr12:56726349 A/G cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs12200560 0.505 rs172425 chr6:97075299 A/T cg06623918 chr6:96969491 KIAA0776 0.53 12.75 0.45 2.46e-33 Coronary heart disease; BRCA trans rs1994135 0.654 rs1447872 chr12:33718343 C/A cg13010199 chr12:38710504 ALG10B 0.43 7.95 0.3 8.65e-15 Resting heart rate; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg02592271 chr2:27665507 KRTCAP3 0.31 7.92 0.3 1.03e-14 Total body bone mineral density; BRCA cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.09 0.51 3.26e-44 Bladder cancer; BRCA cis rs910316 1.000 rs876402 chr14:75601862 C/T cg11812906 chr14:75593930 NEK9 -0.68 -15.85 -0.53 5.71e-48 Height; BRCA cis rs4924935 0.781 rs2472694 chr17:18848498 A/G cg26378065 chr17:18585709 ZNF286B 0.45 8.15 0.31 1.91e-15 Pancreatic cancer; BRCA cis rs2836974 1.000 rs2836974 chr21:40663181 A/G cg11644478 chr21:40555479 PSMG1 -0.83 -18.8 -0.6 4.12e-63 Cognitive function; BRCA trans rs11098499 0.863 rs17050695 chr4:120489527 G/T cg25214090 chr10:38739885 LOC399744 0.47 10.65 0.39 1.73e-24 Corneal astigmatism; BRCA cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg18016565 chr1:150552671 MCL1 -0.41 -9.43 -0.35 7.2e-20 Tonsillectomy; BRCA cis rs2762353 0.595 rs10498728 chr6:25751320 A/T cg12310025 chr6:25882481 NA -0.75 -18.47 -0.59 2.43e-61 Blood metabolite levels; BRCA cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg19257562 chr1:2043853 PRKCZ 0.38 10.51 0.38 6.28e-24 Height; BRCA cis rs7727544 0.735 rs274568 chr5:131713578 C/T cg07395648 chr5:131743802 NA 0.38 9.52 0.35 3.48e-20 Blood metabolite levels; BRCA trans rs7618501 0.602 rs34831713 chr3:50118748 T/C cg21659725 chr3:3221576 CRBN -0.47 -11.9 -0.43 1.24e-29 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg07917127 chr4:99064746 C4orf37 0.42 7.97 0.3 7.51e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -14.01 -0.48 4.2e-39 Extrinsic epigenetic age acceleration; BRCA trans rs10242455 0.702 rs3528 chr7:99055940 T/C cg09045935 chr12:6379348 NA 0.89 9.35 0.35 1.41e-19 Blood metabolite levels; BRCA trans rs17685 0.753 rs1806885 chr7:75785612 T/G cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1865760 0.566 rs2032449 chr6:26026599 G/C cg16482183 chr6:26056742 HIST1H1C 0.55 11.74 0.42 5.81e-29 Height; BRCA cis rs507080 0.663 rs7926970 chr11:118559881 T/G cg09144398 chr11:118550485 TREH -0.38 -8.96 -0.33 3.57e-18 Serum metabolite levels; BRCA cis rs7618915 0.547 rs34017441 chr3:52742413 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.79 -0.45 1.57e-33 Bipolar disorder; BRCA cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg02503808 chr4:7069936 GRPEL1 0.81 17.8 0.58 6.91e-58 Monocyte percentage of white cells; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg14004847 chr7:1930337 MAD1L1 -0.4 -7.98 -0.3 6.57e-15 Bipolar disorder and schizophrenia; BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg00106254 chr7:1943704 MAD1L1 -0.37 -9.0 -0.34 2.64e-18 Bipolar disorder and schizophrenia; BRCA cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.99 0.51 9.36e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7267979 0.739 rs6138555 chr20:25242910 G/A cg08601574 chr20:25228251 PYGB 0.4 9.47 0.35 5.42e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8114671 0.527 rs3736802 chr20:33604042 T/C cg24642439 chr20:33292090 TP53INP2 -0.44 -9.73 -0.36 5.86e-21 Height; BRCA cis rs6089584 0.627 rs13045575 chr20:60565596 G/A cg13770153 chr20:60521292 NA -0.4 -9.44 -0.35 6.82e-20 Body mass index; BRCA cis rs10924970 0.934 rs3856241 chr1:235429692 G/A cg26050004 chr1:235667680 B3GALNT2 0.34 8.45 0.32 1.9e-16 Asthma; BRCA cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg04166393 chr7:2884313 GNA12 0.4 8.59 0.32 6.59e-17 Height; BRCA trans rs9325144 0.647 rs61931899 chr12:38892422 A/G cg23762105 chr12:34175262 ALG10 0.35 8.25 0.31 9.16e-16 Morning vs. evening chronotype; BRCA cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -9.5 -0.35 3.98e-20 Aortic root size; BRCA trans rs7647973 0.593 rs1799844 chr3:49847642 G/A cg21659725 chr3:3221576 CRBN 0.48 8.04 0.3 4.35e-15 Menarche (age at onset); BRCA cis rs2832077 0.527 rs2250141 chr21:30241984 A/T cg08807101 chr21:30365312 RNF160 0.5 11.08 0.4 3.31e-26 Cognitive test performance; BRCA cis rs4595586 0.545 rs11615634 chr12:39364704 A/C cg26384229 chr12:38710491 ALG10B 0.41 9.2 0.34 5.01e-19 Morning vs. evening chronotype; BRCA cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg08222618 chr4:941054 TMEM175 0.36 7.81 0.3 2.33e-14 Sjögren's syndrome; BRCA cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.47 -0.44 4.3e-32 Bipolar disorder; BRCA cis rs1008375 0.932 rs7677212 chr4:17675932 A/G cg15017067 chr4:17643749 FAM184B -0.26 -7.9 -0.3 1.22e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4319547 0.656 rs7397299 chr12:122821649 G/T cg05707623 chr12:122985044 ZCCHC8 -0.37 -7.81 -0.3 2.43e-14 Body mass index; BRCA cis rs922182 0.595 rs7176387 chr15:64219108 A/G cg24729988 chr15:64271149 DAPK2 -0.46 -9.56 -0.35 2.49e-20 Blood protein levels; BRCA trans rs7647973 0.626 rs4855849 chr3:49653378 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.65 -0.32 4.23e-17 Menarche (age at onset); BRCA cis rs2832191 0.740 rs2853830 chr21:30416824 A/G cg24692254 chr21:30365293 RNF160 0.77 21.21 0.64 5.42e-76 Dental caries; BRCA cis rs2204008 0.687 rs11181339 chr12:38322271 G/T cg26384229 chr12:38710491 ALG10B 0.63 15.09 0.51 2.97e-44 Bladder cancer; BRCA cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg02544614 chr20:61657117 NA 0.29 8.09 0.3 3e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg07148914 chr20:33460835 GGT7 0.43 8.78 0.33 1.44e-17 Glomerular filtration rate (creatinine); BRCA cis rs7617773 0.780 rs13066758 chr3:48343877 G/A cg11946769 chr3:48343235 NME6 0.69 13.87 0.48 2.01e-38 Coronary artery disease; BRCA cis rs9653442 0.675 rs1115910 chr2:100647872 A/G cg22139774 chr2:100720529 AFF3 -0.29 -8.27 -0.31 7.82e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs8114671 0.527 rs6088650 chr20:33514465 C/T cg24642439 chr20:33292090 TP53INP2 -0.43 -9.17 -0.34 6.32e-19 Height; BRCA trans rs11098499 0.863 rs7657849 chr4:120455494 T/C cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs2806561 0.704 rs6680974 chr1:23376233 A/G cg19743168 chr1:23544995 NA 0.35 8.04 0.3 4.5e-15 Height; BRCA cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08109568 chr15:31115862 NA -0.51 -12.59 -0.45 1.31e-32 Huntington's disease progression; BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg04944784 chr2:26401820 FAM59B -0.69 -11.41 -0.41 1.37e-27 Gut microbiome composition (summer); BRCA cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.65 0.39 1.68e-24 Bipolar disorder; BRCA cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg25809561 chr17:30822961 MYO1D 0.4 9.5 0.35 4.06e-20 Schizophrenia; BRCA cis rs9790314 0.875 rs462514 chr3:161092809 C/T cg04691961 chr3:161091175 C3orf57 -0.58 -14.99 -0.51 9.31e-44 Morning vs. evening chronotype; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.87 0.36 1.77e-21 Tonsillectomy; BRCA cis rs3125734 0.671 rs3852406 chr10:64015162 T/C cg19640130 chr10:64028056 RTKN2 -0.29 -8.46 -0.32 1.84e-16 Rheumatoid arthritis; BRCA cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14240646 chr10:27532245 ACBD5 0.74 9.4 0.35 9.27e-20 Breast cancer; BRCA cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg24675658 chr1:53192096 ZYG11B 0.66 14.4 0.5 6.21e-41 Monocyte count; BRCA cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg05283184 chr6:79620031 NA -0.38 -9.57 -0.35 2.21e-20 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg03354898 chr7:1950403 MAD1L1 -0.56 -12.57 -0.45 1.58e-32 Bipolar disorder and schizophrenia; BRCA cis rs2014572 0.510 rs8111661 chr19:57752326 C/G cg24459738 chr19:57751996 ZNF805 0.4 9.58 0.35 2.08e-20 Hyperactive-impulsive symptoms; BRCA cis rs7945705 0.902 rs10743095 chr11:8936984 T/C cg12365402 chr11:9010492 NRIP3 0.41 9.25 0.34 3.33e-19 Hemoglobin concentration; BRCA cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.865 rs769948 chr2:200728475 C/A cg23649088 chr2:200775458 C2orf69 0.61 9.06 0.34 1.54e-18 Schizophrenia; BRCA cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs11758351 0.660 rs16891443 chr6:26221937 A/C cg01420254 chr6:26195488 NA 0.57 8.81 0.33 1.15e-17 Gout;Renal underexcretion gout; BRCA cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg24229701 chr12:130821962 PIWIL1 0.39 8.93 0.33 4.4e-18 Menopause (age at onset); BRCA cis rs2070488 0.804 rs13094715 chr3:38504430 G/A cg24069376 chr3:38537580 EXOG 0.33 9.4 0.35 9.8e-20 Electrocardiographic conduction measures; BRCA cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg21854759 chr1:92012499 NA -0.42 -9.8 -0.36 3.14e-21 Breast cancer; BRCA cis rs17685 0.753 rs1637039 chr7:75693009 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.8 -0.33 1.31e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs17401966 0.522 rs946504 chr1:10308597 T/C cg03954927 chr1:10346856 KIF1B 0.34 10.46 0.38 9.71e-24 Hepatocellular carcinoma; BRCA cis rs1691799 0.867 rs1168297 chr12:66735644 T/C cg16791601 chr12:66731901 HELB -0.65 -17.57 -0.57 1.16e-56 White blood cell count (basophil); BRCA cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.47 8.65 0.32 4.02e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4363385 0.818 rs419721 chr1:153006902 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs7833790 1.000 rs7833384 chr8:82730915 T/C cg17211192 chr8:82754475 SNX16 -0.61 -11.94 -0.43 8.29e-30 Diastolic blood pressure; BRCA cis rs503734 0.502 rs348876 chr3:100930989 A/G cg27318481 chr3:100970896 IMPG2 -0.36 -8.61 -0.32 5.81e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11112613 0.762 rs66754070 chr12:105949779 G/A cg03607813 chr12:105948248 NA 0.6 11.29 0.41 4.64e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA trans rs17685 0.593 rs56265719 chr7:75796269 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 25.25 0.71 4.33e-98 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg25036284 chr2:26402008 FAM59B -0.89 -15.1 -0.51 2.72e-44 Gut microbiome composition (summer); BRCA cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.58e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10927875 0.864 rs12744578 chr1:16173110 A/T cg21385522 chr1:16154831 NA -0.88 -16.46 -0.55 4.99e-51 Dilated cardiomyopathy; BRCA cis rs6540559 0.611 rs11810817 chr1:210011747 C/G cg22029157 chr1:209979665 IRF6 0.41 8.06 0.3 3.66e-15 Cleft lip with or without cleft palate; BRCA cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.33 -0.38 2.99e-23 Reticulocyte count; BRCA cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg00012203 chr2:219082015 ARPC2 0.49 9.53 0.35 3.12e-20 Colorectal cancer; BRCA cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg02297831 chr4:17616191 MED28 -0.34 -8.0 -0.3 5.95e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg00934597 chr7:893267 UNC84A -0.51 -11.19 -0.4 1.13e-26 Perceived unattractiveness to mosquitoes; BRCA cis rs9486719 0.947 rs72932805 chr6:96902933 T/G cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.66e-34 Migraine;Coronary artery disease; BRCA cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg26384229 chr12:38710491 ALG10B 0.67 14.37 0.49 9.24e-41 Heart rate; BRCA cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg26597838 chr10:835615 NA 1.31 21.35 0.65 9.17e-77 Eosinophil percentage of granulocytes; BRCA cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 10.92 0.4 1.46e-25 Bipolar disorder; BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.28 -0.41 4.78e-27 Gut microbiome composition (summer); BRCA cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg01939980 chr4:1354348 KIAA1530 0.39 10.81 0.39 4.01e-25 Longevity; BRCA cis rs6728642 0.808 rs113319086 chr2:97633267 G/C cg26665480 chr2:98280029 ACTR1B -0.67 -7.86 -0.3 1.65e-14 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.95 -0.3 8.63e-15 Aortic root size; BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg00814883 chr7:100076585 TSC22D4 -0.49 -10.26 -0.38 5.9e-23 Platelet count; BRCA cis rs2880765 0.835 rs7163958 chr15:86045215 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.44 -0.32 2.07e-16 Coronary artery disease; BRCA cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg18876405 chr7:65276391 NA 0.48 10.79 0.39 4.88e-25 Aortic root size; BRCA cis rs7589728 1.000 rs75309929 chr2:88524377 T/C cg24977027 chr2:88469347 THNSL2 0.47 8.17 0.31 1.59e-15 Plasma clusterin levels; BRCA cis rs34779708 0.966 rs17499811 chr10:35456215 G/A cg03585969 chr10:35415529 CREM 0.56 11.58 0.42 2.9e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.06e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs11190604 1.000 rs2298074 chr10:102247526 G/C cg07080220 chr10:102295463 HIF1AN 0.56 11.9 0.43 1.27e-29 Palmitoleic acid (16:1n-7) levels; BRCA cis rs8014204 0.781 rs10143492 chr14:75212114 G/C cg06637938 chr14:75390232 RPS6KL1 0.45 9.33 0.35 1.66e-19 Caffeine consumption; BRCA cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg26647111 chr11:31128758 NA 0.44 9.59 0.35 1.8899999999999998e-20 Red blood cell count; BRCA cis rs79057730 0.599 rs6944167 chr7:826274 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.62 9.12 0.34 9.81e-19 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs4699331 chr4:99059816 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7524258 0.868 rs11120885 chr1:7306755 C/G cg07173049 chr1:7289937 CAMTA1 0.41 9.97 0.37 7.37e-22 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26119090 chr2:26468346 HADHA;HADHB -1.01 -22.16 -0.66 3.76e-81 Gut microbiome composition (summer); BRCA cis rs60843830 1.000 rs17713396 chr2:227201 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.69 13.61 0.47 3.32e-37 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs61931739 0.534 rs10844816 chr12:34248533 C/A cg26384229 chr12:38710491 ALG10B 0.67 14.24 0.49 3.8e-40 Morning vs. evening chronotype; BRCA cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg05234568 chr11:5960015 NA -0.49 -9.65 -0.36 1.15e-20 DNA methylation (variation); BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg03923535 chr7:1197113 ZFAND2A 0.48 9.63 0.36 1.34e-20 Longevity;Endometriosis; BRCA cis rs6570726 0.935 rs424263 chr6:145840073 A/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs6545883 0.791 rs4672445 chr2:61655008 T/C cg15711740 chr2:61764176 XPO1 0.56 14.37 0.49 8.46e-41 Tuberculosis; BRCA cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.73 0.48 8.61e-38 Coronary artery disease; BRCA cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.57 -0.35 2.2e-20 Tonsillectomy; BRCA cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.92 0.4 1.4e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs2197308 0.765 rs10880643 chr12:37926452 C/T cg06521331 chr12:34319734 NA 0.46 8.91 0.33 5.31e-18 Morning vs. evening chronotype; BRCA cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.52 -10.77 -0.39 5.93e-25 Chronic sinus infection; BRCA trans rs61931739 0.553 rs68124042 chr12:34064431 C/A cg26384229 chr12:38710491 ALG10B 0.68 14.12 0.49 1.38e-39 Morning vs. evening chronotype; BRCA cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs757110 0.648 rs12146443 chr11:17384498 T/C cg04705435 chr11:17411270 KCNJ11 0.43 9.32 0.35 1.89e-19 Type 2 diabetes; BRCA cis rs6964587 0.626 rs10243083 chr7:91552530 G/A cg17063962 chr7:91808500 NA -0.56 -12.82 -0.45 1.23e-33 Breast cancer; BRCA cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg24812749 chr6:127587940 RNF146 0.68 15.41 0.52 8.21e-46 Breast cancer; BRCA trans rs2562456 0.837 rs11085462 chr19:21750251 C/G cg25042112 chr7:64838748 ZNF92 -0.45 -8.23 -0.31 1.03e-15 Pain; BRCA cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg16482183 chr6:26056742 HIST1H1C 0.56 11.86 0.42 1.79e-29 Height; BRCA cis rs9443645 0.901 rs9448590 chr6:79606429 C/G cg18132916 chr6:79620363 NA -0.48 -10.89 -0.4 1.89e-25 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.43 0.35 7.23e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -12.17 -0.43 8.6e-31 Bipolar disorder and schizophrenia; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -13.16 -0.46 3.72e-35 Platelet count; BRCA cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -9.23 -0.34 3.82e-19 Menopause (age at onset); BRCA cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.4 -0.32 2.97e-16 Colorectal cancer; BRCA cis rs1448094 0.512 rs2405632 chr12:86252456 A/G cg19622623 chr12:86230825 RASSF9 -0.35 -9.69 -0.36 8.31e-21 Major depressive disorder; BRCA cis rs2742234 0.759 rs12241923 chr10:43713047 T/C cg02780029 chr10:43622663 RET 0.32 7.97 0.3 7.44e-15 Hirschsprung disease; BRCA cis rs921968 0.541 rs7574429 chr2:219498759 T/G cg02176678 chr2:219576539 TTLL4 0.5 12.72 0.45 3.34e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg26874164 chr19:58962979 ZNF324B 0.44 9.29 0.35 2.3e-19 Uric acid clearance; BRCA cis rs1113500 0.702 rs11185262 chr1:108639742 C/T cg06207961 chr1:108661230 NA 0.45 10.95 0.4 1.11e-25 Growth-regulated protein alpha levels; BRCA cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs13118159 0.550 rs10016557 chr4:1363628 C/T cg16405210 chr4:1374714 KIAA1530 0.87 19.83 0.62 1.54e-68 Longevity; BRCA cis rs7647973 0.593 rs62262730 chr3:49808274 T/G cg03060546 chr3:49711283 APEH -0.57 -8.86 -0.33 7.59e-18 Menarche (age at onset); BRCA cis rs701145 0.585 rs1727947 chr3:153879467 C/T cg17054900 chr3:154042577 DHX36 0.49 8.55 0.32 8.93e-17 Coronary artery disease; BRCA cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.44 -0.32 2.14e-16 Developmental language disorder (linguistic errors); BRCA cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.36e-36 Mean platelet volume; BRCA cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg21573476 chr21:45109991 RRP1B -0.34 -9.13 -0.34 8.86e-19 Mean corpuscular volume; BRCA cis rs12579753 0.956 rs7309624 chr12:82204266 C/A cg07988820 chr12:82153109 PPFIA2 -0.66 -10.68 -0.39 1.32e-24 Resting heart rate; BRCA cis rs10779751 1.000 rs1135172 chr1:11301714 C/T cg08854313 chr1:11322531 MTOR -0.8 -16.7 -0.55 3.11e-52 Body mass index; BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.59 9.16 0.34 7.02e-19 Renal function-related traits (BUN); BRCA cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg02012338 chr4:187126139 CYP4V2 -0.84 -9.98 -0.37 6.55e-22 Blood protein levels; BRCA trans rs11764590 0.715 rs11760737 chr7:2104055 T/C cg25206134 chr2:45395956 NA 0.49 7.86 0.3 1.67e-14 Neuroticism; BRCA cis rs7814319 0.966 rs10112328 chr8:97254372 C/T cg20787634 chr8:97240163 UQCRB 0.46 10.14 0.37 1.65e-22 Lung function (FVC); BRCA cis rs2286885 0.896 rs62578061 chr9:129248219 C/T cg15282417 chr9:129245246 FAM125B 0.3 7.86 0.3 1.7e-14 Intraocular pressure; BRCA cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.28 -0.44 2.95e-31 Tonsillectomy; BRCA cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 20.41 0.63 1.11e-71 Smoking behavior; BRCA cis rs11112613 0.713 rs17037317 chr12:105952058 T/C cg03607813 chr12:105948248 NA 0.55 10.43 0.38 1.25e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs1401999 1.000 rs6802849 chr3:183698943 A/C cg01324343 chr3:183735012 ABCC5 0.85 21.49 0.65 1.68e-77 Anterior chamber depth; BRCA cis rs55692411 0.537 rs35375092 chr3:50065274 G/A cg14019146 chr3:50243930 SLC38A3 -0.58 -11.97 -0.43 6.2e-30 Intelligence (multi-trait analysis); BRCA cis rs9640161 0.830 rs3757425 chr7:150067640 A/C cg21361702 chr7:150065534 REPIN1 0.51 10.44 0.38 1.13e-23 Blood protein levels;Circulating chemerin levels; BRCA cis rs7267979 1.000 rs1888998 chr20:25291826 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.52 -0.32 1.14e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs6066825 0.644 rs2092492 chr20:47338650 A/G cg18078177 chr20:47281410 PREX1 0.39 9.51 0.35 3.76e-20 Colorectal cancer; BRCA cis rs27434 0.607 rs34750 chr5:96142806 G/C cg16492584 chr5:96139282 ERAP1 -0.5 -13.01 -0.46 1.76e-34 Ankylosing spondylitis; BRCA cis rs637571 0.726 rs689274 chr11:65665988 A/G cg02427764 chr11:65769310 BANF1;EIF1AD -0.42 -8.66 -0.32 3.83e-17 Eosinophil percentage of white cells; BRCA cis rs939658 0.967 rs11629665 chr15:79457133 C/T cg17916960 chr15:79447300 NA 0.38 9.5 0.35 4.02e-20 Refractive error; BRCA cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg24829409 chr8:58192753 C8orf71 -0.59 -12.09 -0.43 1.86e-30 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.23 0.41 7.56e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11890956 chr21:40555474 PSMG1 1.04 29.27 0.76 3.97e-120 Cognitive function; BRCA cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 9.1 0.34 1.14e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs7945718 0.875 rs9888179 chr11:12782601 G/T cg25843174 chr11:12811716 TEAD1 0.22 8.7 0.33 2.87e-17 Educational attainment (years of education); BRCA trans rs11098499 0.697 rs4560394 chr4:120313435 T/G cg25214090 chr10:38739885 LOC399744 0.51 11.31 0.41 3.77e-27 Corneal astigmatism; BRCA cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg06022373 chr22:39101656 GTPBP1 0.73 18.11 0.58 1.89e-59 Menopause (age at onset); BRCA cis rs11098499 0.909 rs7681214 chr4:120385320 C/A cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs4845875 0.563 rs10864540 chr1:11838099 A/G cg24844545 chr1:11908347 NPPA 0.37 8.68 0.32 3.35e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6582630 0.598 rs11182207 chr12:38477514 T/C cg26384229 chr12:38710491 ALG10B -0.42 -9.88 -0.36 1.6e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs7582180 0.764 rs12712075 chr2:100924129 T/C cg14675211 chr2:100938903 LONRF2 0.49 11.2 0.4 1.09e-26 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg01579765 chr21:45077557 HSF2BP -0.38 -10.36 -0.38 2.43e-23 Mean corpuscular volume; BRCA cis rs3739998 0.527 rs4749524 chr10:30332618 G/C cg12786570 chr10:30316432 KIAA1462 0.49 9.69 0.36 8.39e-21 Coronary heart disease; BRCA cis rs16944613 0.541 rs7183319 chr15:91095032 A/T cg26821196 chr15:91095069 CRTC3 0.45 8.63 0.32 4.85e-17 Colorectal cancer; BRCA cis rs2288073 0.801 rs2384008 chr2:24373150 A/G cg06627628 chr2:24431161 ITSN2 -0.57 -11.12 -0.4 2.24e-26 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs943466 1.000 rs7755323 chr6:33761159 A/G cg25922239 chr6:33757077 LEMD2 -0.37 -8.35 -0.31 4.17e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA trans rs6951245 0.572 rs112072378 chr7:1039400 C/T cg13565492 chr6:43139072 SRF -0.79 -8.14 -0.31 2.15e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.7 -0.33 2.89e-17 Monocyte percentage of white cells; BRCA cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg11632617 chr15:75315747 PPCDC 0.4 8.7 0.33 2.89e-17 Blood trace element (Zn levels); BRCA cis rs737008 0.960 rs949429 chr16:11376029 C/T cg00044050 chr16:11439710 C16orf75 -0.36 -7.95 -0.3 8.64e-15 Obesity-related traits; BRCA cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -18.12 -0.58 1.55e-59 Extrinsic epigenetic age acceleration; BRCA cis rs611744 0.647 rs633901 chr8:109242981 G/T cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg12311346 chr5:56204834 C5orf35 0.56 11.8 0.42 3.3600000000000003e-29 Initial pursuit acceleration; BRCA cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.77 0.39 5.51e-25 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg11764359 chr7:65958608 NA -0.79 -19.09 -0.6 1.29e-64 Aortic root size; BRCA cis rs34779708 0.931 rs6481935 chr10:35342959 C/T cg03585969 chr10:35415529 CREM 0.46 9.52 0.35 3.37e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2878628 0.650 rs56098033 chr3:52758571 T/A cg10802521 chr3:52805072 NEK4 -0.34 -9.33 -0.35 1.73e-19 Intelligence (multi-trait analysis); BRCA cis rs7572733 0.534 rs700682 chr2:198712310 C/A cg00792783 chr2:198669748 PLCL1 0.47 10.11 0.37 2.17e-22 Dermatomyositis; BRCA cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg20203395 chr5:56204925 C5orf35 -0.5 -10.11 -0.37 2.13e-22 Initial pursuit acceleration; BRCA cis rs1595825 0.838 rs57437055 chr2:198782617 A/C cg19156104 chr2:198669113 PLCL1 -0.41 -7.84 -0.3 1.89e-14 Ulcerative colitis; BRCA cis rs12760731 0.720 rs12026110 chr1:178410984 G/A cg00404053 chr1:178313656 RASAL2 0.61 7.92 0.3 1.09e-14 Obesity-related traits; BRCA cis rs708547 0.874 rs1713984 chr4:57886493 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 10.69 0.39 1.17e-24 Response to bleomycin (chromatid breaks); BRCA cis rs2073300 1.000 rs6106669 chr20:23460328 C/T cg12062639 chr20:23401060 NAPB 0.6 8.67 0.32 3.63e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11690935 0.550 rs62183769 chr2:172838074 A/C cg13550731 chr2:172543902 DYNC1I2 0.5 12.07 0.43 2.43e-30 Schizophrenia; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg12444411 chr7:2802554 GNA12 -0.38 -9.45 -0.35 6.34e-20 Height; BRCA cis rs9788682 0.747 rs2656073 chr15:78742276 G/T cg24631222 chr15:78858424 CHRNA5 0.45 8.94 0.33 4.3e-18 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs11711311 0.955 rs34458493 chr3:113396473 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.31 7.92 0.3 1.03e-14 IgG glycosylation; BRCA cis rs57590327 0.503 rs13079104 chr3:81886039 A/T cg07356753 chr3:81810745 GBE1 -0.45 -10.54 -0.38 4.61e-24 Extraversion; BRCA cis rs7903847 0.642 rs9887991 chr10:99159634 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.45 -0.32 1.91e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs13191362 0.872 rs73017702 chr6:163257695 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.65 9.8 0.36 3.27e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs941408 1.000 rs1640271 chr19:2799979 C/T cg19676328 chr12:49525230 TUBA1B -0.51 -11.75 -0.42 5.34e-29 Total cholesterol levels; BRCA cis rs2073300 1.000 rs115730610 chr20:23442621 G/A cg12062639 chr20:23401060 NAPB 0.87 10.4 0.38 1.58e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10465746 0.653 rs11163877 chr1:84441848 T/A cg10977910 chr1:84465055 TTLL7 0.57 12.06 0.43 2.46e-30 Obesity-related traits; BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.88 -0.3 1.41e-14 Menopause (age at onset); BRCA cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg17143192 chr8:8559678 CLDN23 0.57 12.35 0.44 1.48e-31 Obesity-related traits; BRCA cis rs6748734 1.000 rs6751693 chr2:241837332 T/C cg07537917 chr2:241836409 C2orf54 -0.45 -9.99 -0.37 5.99e-22 Urinary metabolites; BRCA cis rs875971 0.756 rs2901210 chr7:66017505 G/A cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA cis rs7633857 0.532 rs1580254 chr3:160767278 C/T cg03342759 chr3:160939853 NMD3 -0.58 -12.22 -0.44 5.13e-31 Educational attainment (years of education); BRCA trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs826838 0.967 rs1719856 chr12:39127201 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.27 -0.38 5.1e-23 Heart rate; BRCA cis rs875971 0.522 rs6960048 chr7:65408039 A/G cg11764359 chr7:65958608 NA 0.61 13.43 0.47 2.03e-36 Aortic root size; BRCA cis rs9880211 0.898 rs6770476 chr3:136073920 C/T cg21827317 chr3:136751795 NA -0.41 -8.34 -0.31 4.7e-16 Body mass index;Height; BRCA cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 8.02e-41 Motion sickness; BRCA cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.04 0.4 4.7e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs9944715 0.954 rs8093407 chr18:43849464 A/G cg01718231 chr17:29326311 RNF135 -0.45 -8.93 -0.33 4.67e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg13256891 chr4:100009986 ADH5 0.38 8.18 0.31 1.49e-15 Alcohol dependence; BRCA cis rs875971 1.000 rs1363055 chr7:65943275 A/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.42 8.06 0.3 3.66e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2204008 0.555 rs7310307 chr12:38107497 G/T cg26384229 chr12:38710491 ALG10B 0.77 16.47 0.55 4.85e-51 Bladder cancer; BRCA cis rs2658782 1.000 rs2658778 chr11:93148948 C/G cg15737290 chr11:93063684 CCDC67 0.5 9.71 0.36 7.03e-21 Pulmonary function decline; BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -13.75 -0.48 7.45e-38 Initial pursuit acceleration; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg03354898 chr7:1950403 MAD1L1 -0.4 -8.38 -0.31 3.31e-16 Bipolar disorder and schizophrenia; BRCA cis rs2404602 0.735 rs62028423 chr15:76754514 G/A cg23625390 chr15:77176239 SCAPER -0.5 -12.18 -0.43 7.72e-31 Blood metabolite levels; BRCA cis rs12210905 0.688 rs12193557 chr6:27435944 T/C cg08851530 chr6:28072375 NA 0.81 7.97 0.3 7.05e-15 Hip circumference adjusted for BMI; BRCA trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg11707556 chr5:10655725 ANKRD33B -0.45 -10.06 -0.37 3.43e-22 Height; BRCA cis rs1267303 0.642 rs114746843 chr1:46999239 C/A cg25110126 chr1:46999211 NA 0.74 13.93 0.48 1.1e-38 Monobrow; BRCA cis rs34779708 0.733 rs4934740 chr10:35547141 C/T cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -8.98 -0.33 2.96e-18 Alzheimer's disease (late onset); BRCA trans rs7647973 0.626 rs11720705 chr3:49753788 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.96 -0.33 3.51e-18 Menarche (age at onset); BRCA cis rs4304924 0.500 rs7339081 chr13:79235501 A/G cg05295671 chr13:79234353 RNF219 0.59 10.56 0.39 3.83e-24 Large artery stroke; BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs1003719 0.715 rs8129942 chr21:38552070 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.3 -0.49 1.94e-40 Eye color traits; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg11814155 chr7:99998594 ZCWPW1 0.56 9.42 0.35 7.84e-20 Platelet count; BRCA cis rs7267979 1.000 rs7267979 chr20:25298087 C/T cg08601574 chr20:25228251 PYGB 0.35 8.45 0.32 1.89e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.08 0.34 1.34e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6912958 0.500 rs9342104 chr6:87798512 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.55 -0.32 8.89e-17 Monocyte percentage of white cells; BRCA cis rs78487399 0.808 rs13414619 chr2:43699406 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.55 -7.99 -0.3 6.25e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg17971929 chr21:40555470 PSMG1 -0.47 -10.15 -0.37 1.59e-22 Menarche (age at onset); BRCA cis rs2806561 0.765 rs1997866 chr1:23512524 A/G cg12483005 chr1:23474871 LUZP1 0.44 9.88 0.36 1.57e-21 Height; BRCA cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg05283184 chr6:79620031 NA -0.42 -10.75 -0.39 6.97e-25 Intelligence (multi-trait analysis); BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg13567636 chr1:160991154 F11R -0.48 -9.36 -0.35 1.35e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg19257562 chr1:2043853 PRKCZ -0.35 -9.21 -0.34 4.6e-19 Height; BRCA trans rs4714291 0.832 rs1923462 chr6:39976100 T/C cg02267698 chr19:7991119 CTXN1 -0.46 -9.35 -0.35 1.49e-19 Strep throat; BRCA cis rs4363385 0.693 rs2339487 chr1:152983528 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.54e-16 Inflammatory skin disease; BRCA cis rs3784262 0.527 rs1441815 chr15:58274229 A/C cg12031962 chr15:58353849 ALDH1A2 -0.33 -8.52 -0.32 1.16e-16 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7927771 1.000 rs4752797 chr11:47874364 C/T cg18512352 chr11:47633146 NA -0.35 -8.4 -0.32 2.8e-16 Subjective well-being; BRCA cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg12893428 chr3:195717962 SDHAP1 0.34 8.38 0.31 3.49e-16 Pancreatic cancer; BRCA cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.81 0.33 1.2e-17 Motion sickness; BRCA cis rs7264396 0.747 rs2425112 chr20:34319775 A/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.16 0.31 1.85e-15 Total cholesterol levels; BRCA trans rs7939886 0.920 rs1905069 chr11:55887135 T/C cg15704280 chr7:45808275 SEPT13 0.61 7.94 0.3 9.12e-15 Myopia (pathological); BRCA cis rs9653442 0.712 rs7582731 chr2:100686486 T/C cg22139774 chr2:100720529 AFF3 -0.29 -8.11 -0.31 2.56e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs2032447 0.765 rs6942072 chr6:26014987 A/G cg03517284 chr6:25882590 NA -0.39 -8.18 -0.31 1.48e-15 Intelligence (multi-trait analysis); BRCA cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg20224285 chr3:52813920 ITIH1 0.33 8.17 0.31 1.67e-15 Bipolar disorder; BRCA cis rs898097 0.841 rs4986122 chr17:80825500 C/T cg15664640 chr17:80829946 TBCD -0.69 -19.39 -0.61 3.09e-66 Breast cancer; BRCA cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg14844989 chr11:31128820 NA -0.45 -9.65 -0.36 1.18e-20 Red blood cell count; BRCA cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg26031613 chr14:104095156 KLC1 -0.45 -8.81 -0.33 1.17e-17 Schizophrenia; BRCA trans rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05039488 chr6:79577232 IRAK1BP1 -0.36 -8.25 -0.31 9.03e-16 Endometrial cancer; BRCA cis rs2153535 0.541 rs9328471 chr6:8468842 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.25 0.31 9.28e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 9.13 0.34 8.58e-19 Personality dimensions; BRCA trans rs12310956 0.510 rs11612987 chr12:33879130 T/C cg26384229 chr12:38710491 ALG10B 0.4 9.29 0.34 2.43e-19 Morning vs. evening chronotype; BRCA cis rs144658219 1 rs144658219 chr7:80296965 G/GTACTTGAT cg21369886 chr7:80305251 CD36 -0.39 -9.38 -0.35 1.16e-19 Red blood cell count; BRCA cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg00074818 chr8:8560427 CLDN23 0.38 8.37 0.31 3.69e-16 Obesity-related traits; BRCA cis rs72634258 0.554 rs12745962 chr1:7919825 C/T cg00042356 chr1:8021962 PARK7 0.53 8.31 0.31 5.8e-16 Inflammatory bowel disease; BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg22920501 chr2:26401640 FAM59B -0.82 -13.04 -0.46 1.23e-34 Gut microbiome composition (summer); BRCA cis rs113835537 0.529 rs57207756 chr11:66270360 C/T cg24851651 chr11:66362959 CCS 0.51 8.83 0.33 9.85e-18 Airway imaging phenotypes; BRCA cis rs35146811 0.659 rs863450 chr7:99821685 C/T cg22906224 chr7:99728672 NA -0.43 -8.04 -0.3 4.29e-15 Coronary artery disease; BRCA cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.64 0.42 1.61e-28 Age-related macular degeneration (geographic atrophy); BRCA cis rs2276314 1.000 rs1540042 chr18:33555236 C/T cg19628046 chr18:33552617 C18orf21 0.58 11.87 0.43 1.66e-29 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1451375 0.617 rs880029 chr7:50569927 G/C cg18232548 chr7:50535776 DDC -0.42 -9.0 -0.34 2.62e-18 Malaria; BRCA cis rs2249625 0.761 rs2496500 chr6:72884438 G/C cg18830697 chr6:72922368 RIMS1 -0.37 -7.86 -0.3 1.63e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg11764359 chr7:65958608 NA -0.77 -17.78 -0.58 9.23e-58 Aortic root size; BRCA cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg21573476 chr21:45109991 RRP1B -0.36 -9.17 -0.34 6.35e-19 Mean corpuscular volume; BRCA cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg22834771 chr12:69754056 YEATS4 -0.36 -8.77 -0.33 1.57e-17 Blood protein levels; BRCA trans rs7615952 0.576 rs12497295 chr3:125818650 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -10.85 -0.39 2.79e-25 Blood pressure (smoking interaction); BRCA cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -8.44 -0.32 2.2e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089584 0.850 rs6142939 chr20:60627729 A/G cg06108461 chr20:60628389 TAF4 -1.01 -22.73 -0.67 2.96e-84 Body mass index; BRCA cis rs6840360 0.571 rs12650655 chr4:152556075 G/A cg22705602 chr4:152727874 NA -0.33 -8.49 -0.32 1.47e-16 Intelligence (multi-trait analysis); BRCA cis rs2841277 0.708 rs10083496 chr14:105402786 G/A cg21017887 chr14:105400489 NA 0.65 17.46 0.57 4.36e-56 Rheumatoid arthritis; BRCA cis rs7959452 0.590 rs11177643 chr12:69785712 T/G cg14784868 chr12:69753453 YEATS4 0.68 19.79 0.62 2.25e-68 Blood protein levels; BRCA cis rs897080 0.515 rs698795 chr2:44689326 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.44 0.35 6.83e-20 Height; BRCA trans rs9650657 0.644 rs4395858 chr8:10521021 C/T cg08975724 chr8:8085496 FLJ10661 0.41 8.42 0.32 2.54e-16 Neuroticism; BRCA cis rs6963495 0.818 rs73190151 chr7:105152887 C/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.02e-19 Bipolar disorder (body mass index interaction); BRCA cis rs2153535 0.580 rs4960421 chr6:8459292 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg03161606 chr19:29218774 NA 0.46 8.12 0.31 2.49e-15 Methadone dose in opioid dependence; BRCA cis rs708547 1.000 rs10003229 chr4:57809598 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.47 -10.64 -0.39 1.87e-24 Response to bleomycin (chromatid breaks); BRCA trans rs11098499 0.908 rs71614449 chr4:120387055 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs7264396 0.790 rs2425083 chr20:34300456 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.74 -15.9 -0.53 3.24e-48 Total cholesterol levels; BRCA cis rs2625529 0.652 rs8023788 chr15:72459847 A/G cg16672083 chr15:72433130 SENP8 0.66 16.15 0.54 1.76e-49 Red blood cell count; BRCA cis rs867371 1.000 rs11855089 chr15:82447265 T/C cg00614314 chr15:82944287 LOC80154 0.43 9.11 0.34 1.05e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs614226 0.935 rs3887875 chr12:120895749 A/G cg01236616 chr12:121019343 POP5 -1.17 -26.13 -0.72 6.5e-103 Type 1 diabetes nephropathy; BRCA cis rs7246657 0.943 rs8109632 chr19:37931125 A/T cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA cis rs796364 1.000 rs769949 chr2:200729558 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.83 0.42 2.57e-29 Schizophrenia; BRCA cis rs8072100 0.817 rs7213086 chr17:45752310 C/G cg25173405 chr17:45401733 C17orf57 -0.51 -10.35 -0.38 2.53e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6684514 1.000 rs2273833 chr1:156233189 C/T cg16558208 chr1:156270281 VHLL 0.37 8.16 0.31 1.82e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA trans rs7824557 0.767 rs10104728 chr8:11171300 A/G cg06636001 chr8:8085503 FLJ10661 0.54 10.14 0.37 1.73e-22 Retinal vascular caliber; BRCA cis rs7586879 0.616 rs13410999 chr2:25097939 T/C cg04586622 chr2:25135609 ADCY3 0.43 10.7 0.39 1.13e-24 Body mass index; BRCA trans rs66573146 1.000 rs6838042 chr4:6973049 G/T cg07817883 chr1:32538562 TMEM39B 1.41 17.47 0.57 3.73e-56 Granulocyte percentage of myeloid white cells; BRCA cis rs965469 0.779 rs3746630 chr20:3320902 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.82 -0.33 1.11e-17 IFN-related cytopenia; BRCA cis rs7172677 0.737 rs8027604 chr15:75447773 C/T cg14664628 chr15:75095509 CSK -0.42 -9.02 -0.34 2.13e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.62 14.1 0.49 1.62e-39 Platelet count; BRCA cis rs4631830 0.832 rs10825652 chr10:51510761 G/A cg20129853 chr10:51489980 NA 0.29 7.99 0.3 6.29e-15 Prostate-specific antigen levels; BRCA cis rs7737355 0.947 rs6895586 chr5:130588008 C/A cg06307176 chr5:131281290 NA 0.45 8.8 0.33 1.3e-17 Life satisfaction; BRCA cis rs56235845 0.694 rs4532376 chr5:176774403 G/A cg16006841 chr5:176797999 RGS14 0.61 11.88 0.43 1.57e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.95 0.56 1.71e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs11231017 0.507 rs10897267 chr11:62157418 C/T cg23876832 chr11:62092739 NA 0.33 8.23 0.31 1.02e-15 HIV-1 viral setpoint; BRCA cis rs7809950 0.678 rs2237659 chr7:106847492 G/T cg23024343 chr7:107201750 COG5 0.43 8.55 0.32 9.33e-17 Coronary artery disease; BRCA cis rs4974559 0.947 rs10000012 chr4:1357325 C/G cg02980000 chr4:1222292 CTBP1 -0.69 -11.84 -0.42 2.26e-29 Systolic blood pressure; BRCA cis rs2904967 0.852 rs488289 chr11:65039264 T/C cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs9616064 0.853 rs7284865 chr22:46996529 C/T cg05621596 chr22:47072043 GRAMD4 -0.47 -10.03 -0.37 4.55e-22 Urate levels in obese individuals; BRCA cis rs2882667 0.690 rs891996 chr5:138267816 A/G cg04439458 chr5:138467593 SIL1 -0.31 -7.91 -0.3 1.16e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1801251 0.963 rs13011298 chr2:233612996 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.39 0.41 1.76e-27 Coronary artery disease; BRCA cis rs3768617 0.624 rs34105373 chr1:183098387 T/C ch.1.3577855R chr1:183094577 LAMC1 0.46 10.37 0.38 2.14e-23 Fuchs's corneal dystrophy; BRCA cis rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05901451 chr6:126070800 HEY2 0.39 9.4 0.35 9.72e-20 Endometrial cancer; BRCA cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg23422044 chr7:1970798 MAD1L1 -0.55 -9.48 -0.35 5.07e-20 Neuroticism; BRCA cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg00031303 chr3:195681400 NA 0.5 9.65 0.36 1.15e-20 Pancreatic cancer; BRCA cis rs6088580 0.634 rs1205334 chr20:32930369 T/C cg08999081 chr20:33150536 PIGU -0.46 -12.49 -0.44 3.35e-32 Glomerular filtration rate (creatinine); BRCA cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.27 -0.54 4.82e-50 Alzheimer's disease (late onset); BRCA cis rs9986765 1.000 rs9986765 chr7:142835239 C/T cg21852589 chr7:142981689 TMEM139 -0.55 -9.55 -0.35 2.6e-20 Cancer;Dermatomyositis; BRCA cis rs4363385 0.747 rs6668696 chr1:152964910 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.21 -0.34 4.48e-19 Inflammatory skin disease; BRCA cis rs8062405 0.690 rs62034351 chr16:28565489 G/A cg16576597 chr16:28551801 NUPR1 0.35 8.86 0.33 8.13e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg22337977 chr21:31811175 KRTAP15-1 0.33 8.0 0.3 5.92e-15 HDL cholesterol; BRCA cis rs4889609 0.834 rs72785520 chr16:31070778 C/T cg00531865 chr16:30841666 NA -0.36 -8.45 -0.32 2.04e-16 Response to metformin (IC50); BRCA cis rs10751667 0.600 rs11246377 chr11:999796 G/T ch.11.42038R chr11:967971 AP2A2 0.47 14.47 0.5 2.93e-41 Alzheimer's disease (late onset); BRCA cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg20818283 chr2:191399100 TMEM194B -0.39 -9.16 -0.34 7.23e-19 Pulse pressure; BRCA cis rs1003719 0.788 rs2835599 chr21:38466937 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.09 0.49 1.88e-39 Eye color traits; BRCA cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -11.53 -0.42 4.46e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs58235267 0.544 rs12478556 chr2:63341711 T/A cg17519650 chr2:63277830 OTX1 0.38 8.14 0.31 2.03e-15 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs6435862 0.593 rs34732883 chr2:215674371 C/T cg04004882 chr2:215674386 BARD1 -0.75 -17.8 -0.58 7.67e-58 Neuroblastoma (high-risk); BRCA cis rs910316 0.967 rs175502 chr14:75533679 A/G cg08847533 chr14:75593920 NEK9 -0.88 -22.68 -0.67 5.28e-84 Height; BRCA cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs2072499 0.750 rs55910626 chr1:156159909 C/G cg24450063 chr1:156163899 SLC25A44 0.93 17.99 0.58 7.3e-59 Testicular germ cell tumor; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg02353165 chr6:42928485 GNMT 0.75 18.09 0.58 2.25e-59 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.660 rs1860470 chr7:66103694 G/C cg18876405 chr7:65276391 NA -0.62 -15.19 -0.52 1.02e-44 Aortic root size; BRCA cis rs9814567 1.000 rs9850015 chr3:134269541 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.72e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1865760 0.516 rs9393683 chr6:26066198 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 11.21 0.41 9.07e-27 Height; BRCA cis rs6430585 0.528 rs75524146 chr2:136725459 C/T cg07169764 chr2:136633963 MCM6 1.22 23.96 0.69 5.42e-91 Corneal structure; BRCA cis rs4595586 0.545 rs4623945 chr12:39364572 A/T cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.34e-19 Morning vs. evening chronotype; BRCA cis rs78456975 0.527 rs10203194 chr2:1558021 A/G cg26248373 chr2:1572462 NA -0.57 -12.92 -0.46 4.13e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.12 -0.37 2e-22 Intelligence (multi-trait analysis); BRCA trans rs12310956 0.510 rs10743832 chr12:33884146 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.46 0.35 5.83e-20 Morning vs. evening chronotype; BRCA cis rs6740322 0.895 rs28456986 chr2:43553321 A/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.26 -0.44 3.38e-31 Coronary artery disease; BRCA cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.3 0.49 1.82e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg11279151 chr3:101281821 RG9MTD1 -0.52 -10.15 -0.37 1.49e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs9875589 0.915 rs13097822 chr3:13969396 T/A cg19554555 chr3:13937349 NA 0.4 8.36 0.31 4.01e-16 Ovarian reserve; BRCA cis rs3820928 0.845 rs7570869 chr2:227878818 A/C cg11843606 chr2:227700838 RHBDD1 -0.37 -8.1 -0.31 2.75e-15 Pulmonary function; BRCA cis rs2204008 0.818 rs7313608 chr12:38383428 C/A cg26384229 chr12:38710491 ALG10B -0.62 -14.81 -0.51 6.86e-43 Bladder cancer; BRCA cis rs13161895 1.000 rs34603792 chr5:179459287 A/G cg02702477 chr5:179499311 RNF130 0.45 8.45 0.32 2.01e-16 LDL cholesterol; BRCA cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg23649088 chr2:200775458 C2orf69 -0.62 -10.49 -0.38 7.56e-24 Schizophrenia; BRCA cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg00339695 chr16:24857497 SLC5A11 0.52 11.01 0.4 5.92e-26 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg15145296 chr3:125709740 NA -0.55 -8.7 -0.33 2.73e-17 Blood pressure (smoking interaction); BRCA cis rs7584330 0.554 rs77180399 chr2:238442951 G/A cg14458575 chr2:238380390 NA 0.54 8.08 0.3 3.34e-15 Prostate cancer; BRCA cis rs752010 0.905 rs10890150 chr1:42095603 A/C cg06885757 chr1:42089581 HIVEP3 0.29 10.21 0.37 8.87e-23 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs4650994 0.967 rs6681043 chr1:178525957 A/G cg05059571 chr16:84539110 KIAA1609 -0.42 -9.48 -0.35 5.01e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs2859741 0.528 rs59729868 chr1:37493710 G/A cg09363841 chr1:37513479 NA -0.51 -11.1 -0.4 2.62e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs965469 1.000 rs6051724 chr20:3279338 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.24 -0.38 6.8e-23 IFN-related cytopenia; BRCA cis rs75804782 0.641 rs41264155 chr2:239342096 G/A cg18131467 chr2:239335373 ASB1 -0.62 -7.85 -0.3 1.8e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs6815814 0.950 rs5743795 chr4:38832495 C/T cg02016764 chr4:38805732 TLR1 -0.52 -8.09 -0.3 2.92e-15 Breast cancer; BRCA cis rs34779708 0.966 rs4934725 chr10:35398236 T/C cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.98e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs312274 0.674 rs10879340 chr12:41295126 A/C cg17827154 chr12:41323612 CNTN1 -0.43 -10.77 -0.39 5.48e-25 Metabolite levels (X-11787); BRCA cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg06238570 chr21:40685208 BRWD1 -0.39 -7.97 -0.3 7.54e-15 Menarche (age at onset); BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg04518342 chr5:131593106 PDLIM4 0.42 10.1 0.37 2.41e-22 Acylcarnitine levels; BRCA cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11890956 chr21:40555474 PSMG1 0.66 15.39 0.52 1.11e-45 Cognitive function; BRCA cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11890956 chr21:40555474 PSMG1 1.06 30.07 0.77 1.88e-124 Cognitive function; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 20.81 0.64 8.17e-74 Platelet count; BRCA cis rs708547 0.735 rs1277280 chr4:57866872 T/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -10.53 -0.38 5.32e-24 Response to bleomycin (chromatid breaks); BRCA cis rs7903847 0.642 rs2275090 chr10:99148151 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.51 -0.32 1.28e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs17401966 1.000 rs12118323 chr1:10469641 A/G cg19773385 chr1:10388646 KIF1B -0.39 -8.34 -0.31 4.66e-16 Hepatocellular carcinoma; BRCA cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg25208724 chr1:156163844 SLC25A44 0.89 17.93 0.58 1.52e-58 Testicular germ cell tumor; BRCA cis rs17601876 0.814 rs749292 chr15:51558731 A/G cg19946085 chr15:51559439 CYP19A1 0.38 11.61 0.42 2.11e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs3740540 0.530 rs2362505 chr10:126290739 T/G cg04949429 chr10:126290192 LHPP 0.44 12.32 0.44 1.96e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg06784218 chr1:46089804 CCDC17 -0.46 -10.5 -0.38 6.66e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2762353 0.595 rs9467591 chr6:25742699 C/T cg03264133 chr6:25882463 NA -0.7 -16.67 -0.55 4.49e-52 Blood metabolite levels; BRCA trans rs1973993 0.967 rs10875017 chr1:96949526 C/T cg10631902 chr5:14652156 NA 0.52 16.32 0.54 2.52e-50 Weight; BRCA cis rs965469 1.000 rs2236089 chr20:3257194 C/A cg25506879 chr20:3388711 C20orf194 -0.56 -10.94 -0.4 1.18e-25 IFN-related cytopenia; BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg25036284 chr2:26402008 FAM59B -0.64 -10.67 -0.39 1.37e-24 Gut microbiome composition (summer); BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg22963979 chr7:1858916 MAD1L1 -0.37 -7.84 -0.3 1.91e-14 Bipolar disorder and schizophrenia; BRCA cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12292205 chr6:26970375 C6orf41 -0.48 -8.13 -0.31 2.3e-15 Intelligence (multi-trait analysis); BRCA cis rs11585357 0.895 rs72633823 chr1:17630779 G/A cg19159961 chr1:17633534 PADI4 0.58 9.18 0.34 6.01e-19 Hair shape; BRCA cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg03517284 chr6:25882590 NA -0.35 -7.92 -0.3 1.05e-14 Height; BRCA cis rs826838 0.651 rs1843896 chr12:38612913 G/C cg13010199 chr12:38710504 ALG10B 0.37 7.84 0.3 1.91e-14 Heart rate; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg11814155 chr7:99998594 ZCWPW1 0.59 10.15 0.37 1.52e-22 Platelet count; BRCA cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs514406 0.668 rs520281 chr1:53365235 G/C cg08859206 chr1:53392774 SCP2 -0.63 -13.9 -0.48 1.46e-38 Monocyte count; BRCA trans rs7726839 0.540 rs4957080 chr5:644552 A/C cg25482853 chr8:67687455 SGK3 -0.88 -14.36 -0.49 1.02e-40 Obesity-related traits; BRCA cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -12.77 -0.45 1.94e-33 Bipolar disorder; BRCA trans rs11088226 0.681 rs2833902 chr21:33940458 A/G cg09050820 chr6:167586206 TCP10L2 0.78 13.22 0.46 1.92e-35 Gastritis; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs2832191 0.740 rs2832177 chr21:30478353 G/A cg24692254 chr21:30365293 RNF160 -0.79 -22.1 -0.66 7.51e-81 Dental caries; BRCA cis rs1401999 1.000 rs2176824 chr3:183654029 C/G cg20387954 chr3:183756860 HTR3D 0.45 10.14 0.37 1.6e-22 Anterior chamber depth; BRCA cis rs2288073 0.965 rs6545340 chr2:24422269 C/G cg26838691 chr2:24397539 C2orf84 -0.49 -8.85 -0.33 8.53e-18 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9470366 0.527 rs733590 chr6:36645203 A/G cg08179530 chr6:36648295 CDKN1A 0.67 15.97 0.53 1.41e-48 QRS duration; BRCA cis rs1975974 0.872 rs17052344 chr17:21717543 A/G cg18423549 chr17:21743878 NA 0.53 11.68 0.42 1.04e-28 Psoriasis; BRCA cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg14784868 chr12:69753453 YEATS4 0.68 19.79 0.62 2.42e-68 Blood protein levels; BRCA cis rs61931739 0.500 rs7488438 chr12:34531359 G/T cg06521331 chr12:34319734 NA -0.55 -9.86 -0.36 1.89e-21 Morning vs. evening chronotype; BRCA cis rs1997103 1.000 rs6949222 chr7:55411264 C/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1371614 0.632 rs1992311 chr2:27159341 G/A cg00617064 chr2:27272375 NA -0.3 -7.93 -0.3 1.02e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.83 0.3 2.1e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.545 rs12810822 chr12:39391807 T/A cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg24812749 chr6:127587940 RNF146 0.88 20.75 0.63 1.58e-73 Breast cancer; BRCA cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg18196295 chr10:418757 DIP2C -0.41 -9.58 -0.35 2.19e-20 Psychosis in Alzheimer's disease; BRCA trans rs2727020 0.729 rs6485965 chr11:49166730 C/T cg00717180 chr2:96193071 NA 0.32 8.73 0.33 2.16e-17 Coronary artery disease; BRCA cis rs7572733 0.534 rs58374969 chr2:198764363 C/T cg00792783 chr2:198669748 PLCL1 0.49 10.42 0.38 1.37e-23 Dermatomyositis; BRCA cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.21 0.34 4.81e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6598955 0.572 rs12089219 chr1:26638751 C/T cg04990556 chr1:26633338 UBXN11 0.56 9.15 0.34 7.48e-19 Obesity-related traits; BRCA cis rs7772486 0.686 rs9390357 chr6:146129347 A/G cg13319975 chr6:146136371 FBXO30 -0.34 -7.96 -0.3 7.78e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1534166 0.647 rs7355929 chr3:133514190 C/T cg01448562 chr3:133502909 NA 0.39 9.01 0.34 2.41e-18 Alcohol consumption (transferrin glycosylation); BRCA cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg08213375 chr14:104286397 PPP1R13B 0.53 13.74 0.48 7.57e-38 Schizophrenia; BRCA cis rs2625529 0.618 rs6494992 chr15:72420750 G/C cg16672083 chr15:72433130 SENP8 0.65 15.56 0.52 1.55e-46 Red blood cell count; BRCA trans rs877282 0.733 rs11253342 chr10:765072 A/G cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.43 -0.38 1.25e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4481887 0.927 rs10888343 chr1:248446642 A/G cg00666640 chr1:248458726 OR2T12 0.35 8.85 0.33 8.41e-18 Common traits (Other); BRCA cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg17971929 chr21:40555470 PSMG1 0.6 13.8 0.48 4.36e-38 Cognitive function; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg18402987 chr7:1209562 NA 0.52 9.97 0.37 7.17e-22 Longevity;Endometriosis; BRCA cis rs1371614 0.632 rs3739085 chr2:27163044 T/C cg00617064 chr2:27272375 NA -0.31 -8.1 -0.31 2.76e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs57221529 0.655 rs11948381 chr5:568413 A/T cg09021430 chr5:549028 NA -0.66 -16.91 -0.56 2.82e-53 Lung disease severity in cystic fibrosis; BRCA cis rs9611519 0.929 rs12484971 chr22:41439304 A/T cg03806693 chr22:41940476 POLR3H -0.56 -9.75 -0.36 4.8e-21 Neuroticism; BRCA cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg14298792 chr15:30685198 CHRFAM7A -0.4 -7.87 -0.3 1.5e-14 Huntington's disease progression; BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg27170947 chr2:26402098 FAM59B -0.64 -11.34 -0.41 2.73e-27 Gut microbiome composition (summer); BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.13 -0.43 1.25e-30 Alzheimer's disease; BRCA cis rs11585357 0.895 rs877552 chr1:17631236 C/T cg19159961 chr1:17633534 PADI4 0.58 9.59 0.35 1.93e-20 Hair shape; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg11843238 chr5:131593191 PDLIM4 -0.35 -9.17 -0.34 6.36e-19 Breast cancer; BRCA cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg08847533 chr14:75593920 NEK9 -0.88 -22.39 -0.66 1.97e-82 Height; BRCA cis rs7572733 0.515 rs11887138 chr2:198805838 T/A cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.43e-21 Dermatomyositis; BRCA cis rs17270561 0.609 rs4131670 chr6:25738619 T/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.87 0.33 7.32e-18 Iron status biomarkers; BRCA cis rs4363385 0.791 rs10788855 chr1:153002359 A/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.32 -0.31 5.19e-16 Inflammatory skin disease; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg10819733 chr22:24237672 NA -0.3 -8.25 -0.31 9.11e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6062302 0.522 rs2236503 chr20:62224595 G/A cg16989086 chr20:62203971 PRIC285 0.53 8.97 0.33 3.29e-18 Glioblastoma; BRCA cis rs17490626 0.568 rs12413525 chr10:71211721 C/A cg12610070 chr10:71211762 TSPAN15 -0.33 -11.77 -0.42 4.44e-29 Thrombosis; BRCA cis rs7677751 0.806 rs4864863 chr4:55100831 A/G cg17187183 chr4:55093834 PDGFRA 0.43 8.84 0.33 9.59e-18 Corneal astigmatism; BRCA cis rs112908525 1 rs112908525 chr7:80305278 T/TGAGGGTTGA cg21369886 chr7:80305251 CD36 -0.4 -9.74 -0.36 5.44e-21 Mean corpuscular volume; BRCA cis rs703842 0.616 rs870392 chr12:58219173 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.52 9.31 0.35 1.94e-19 Multiple sclerosis; BRCA cis rs7394190 0.748 rs3088070 chr10:75530013 C/T cg07699608 chr10:75541558 CHCHD1 0.65 9.64 0.36 1.26e-20 Incident atrial fibrillation; BRCA cis rs16910800 0.731 rs56067480 chr11:23190184 C/T cg20040320 chr11:23191996 NA -0.59 -10.23 -0.38 7.61e-23 Cancer; BRCA cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.07 0.37 3.05e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6964587 1.000 rs1859037 chr7:91568272 A/G cg17063962 chr7:91808500 NA -0.51 -11.89 -0.43 1.32e-29 Breast cancer; BRCA cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.38 0.61 3.87e-66 Cognitive function; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg01305625 chr5:131593812 PDLIM4 0.34 8.07 0.3 3.4e-15 Acylcarnitine levels; BRCA cis rs6912958 0.547 rs451089 chr6:88041859 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.01 0.4 5.99e-26 Monocyte percentage of white cells; BRCA cis rs34891900 0.507 rs738133 chr22:18205557 C/T cg19898043 chr22:18121309 BCL2L13 0.46 9.66 0.36 1.03e-20 Sum neutrophil eosinophil counts; BRCA cis rs775227 0.574 rs60279293 chr3:113096087 T/G cg18753928 chr3:113234510 CCDC52 -0.55 -9.3 -0.35 2.28e-19 Dental caries; BRCA cis rs2153535 0.580 rs1414340 chr6:8491139 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg11161846 chr1:160990452 F11R -0.54 -13.22 -0.46 1.86e-35 Granulocyte percentage of myeloid white cells; BRCA cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg00106254 chr7:1943704 MAD1L1 -0.31 -7.94 -0.3 9.14e-15 Bipolar disorder and schizophrenia; BRCA cis rs2797160 1.000 rs2211418 chr6:125995503 G/A cg05901451 chr6:126070800 HEY2 -0.45 -10.78 -0.39 5.43e-25 Endometrial cancer; BRCA cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg04450456 chr4:17643702 FAM184B 0.41 12.15 0.43 1.06e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8032158 1.000 rs7176225 chr15:56126857 G/A cg02198044 chr15:56286336 NEDD4 -0.38 -9.05 -0.34 1.76e-18 Keloid; BRCA cis rs12618769 0.625 rs72819982 chr2:99043337 A/G cg10123293 chr2:99228465 UNC50 0.4 8.03 0.3 4.87e-15 Bipolar disorder; BRCA cis rs7586879 0.789 rs13404163 chr2:25126616 A/G cg04586622 chr2:25135609 ADCY3 0.4 9.48 0.35 4.86e-20 Body mass index; BRCA cis rs10463316 0.894 rs6579864 chr5:150762181 G/A cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs490234 0.683 rs9409281 chr9:128159171 C/G cg14078157 chr9:128172775 NA -0.36 -8.42 -0.32 2.43e-16 Mean arterial pressure; BRCA cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg21535247 chr6:8435926 SLC35B3 0.41 9.27 0.34 2.9e-19 Motion sickness; BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg20607798 chr8:58055168 NA 0.63 9.54 0.35 2.86e-20 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg04025307 chr7:1156635 C7orf50 0.53 13.44 0.47 1.88e-36 Longevity;Endometriosis; BRCA cis rs7953249 0.656 rs2251468 chr12:121405126 A/C cg02403541 chr12:121454288 C12orf43 0.44 8.64 0.32 4.35e-17 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs7927771 0.698 rs34467936 chr11:47915299 A/G cg18512352 chr11:47633146 NA -0.33 -7.88 -0.3 1.39e-14 Subjective well-being; BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.87 0.53 4.82e-48 Platelet count; BRCA cis rs12477438 0.520 rs13798 chr2:99813614 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 26.38 0.72 2.76e-104 Chronic sinus infection; BRCA cis rs7592578 0.882 rs58568707 chr2:191468987 G/A cg11845111 chr2:191398756 TMEM194B -0.76 -13.92 -0.48 1.2e-38 Diastolic blood pressure; BRCA cis rs778371 0.647 rs974321 chr2:233638351 G/A cg08000102 chr2:233561755 GIGYF2 0.78 16.67 0.55 4.54e-52 Schizophrenia; BRCA cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg14343924 chr8:8086146 FLJ10661 0.4 8.26 0.31 8.36e-16 Mood instability; BRCA cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.25 -9.34 -0.35 1.58e-19 Schizophrenia; BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg21782813 chr7:2030301 MAD1L1 0.39 11.4 0.41 1.55e-27 Bipolar disorder and schizophrenia; BRCA cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.66e-15 Menopause (age at onset); BRCA cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg25801113 chr15:45476975 SHF -0.33 -8.3 -0.31 6.21e-16 Uric acid levels; BRCA cis rs11690935 0.851 rs9808259 chr2:172648974 C/T cg13550731 chr2:172543902 DYNC1I2 -0.91 -31.34 -0.78 2.69e-131 Schizophrenia; BRCA cis rs7945718 0.775 rs10500759 chr11:12822588 A/G cg25843174 chr11:12811716 TEAD1 -0.23 -8.81 -0.33 1.18e-17 Educational attainment (years of education); BRCA cis rs698833 0.620 rs1067354 chr2:44663675 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.4 0.32 2.9e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs6582630 0.519 rs1851121 chr12:38389467 T/C cg06521331 chr12:34319734 NA -0.46 -8.52 -0.32 1.1e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs3733585 0.631 rs4697707 chr4:10119787 G/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.23 -0.38 7.32e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9790314 0.730 rs4856705 chr3:161100219 T/G cg04691961 chr3:161091175 C3orf57 -0.4 -9.39 -0.35 1.04e-19 Morning vs. evening chronotype; BRCA cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg03433033 chr1:76189801 ACADM 0.69 12.93 0.46 3.86e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2304069 0.954 rs216127 chr5:149428890 A/G cg10852222 chr5:149380144 HMGXB3;TIGD6 0.52 7.97 0.3 7.39e-15 HIV-1 control; BRCA cis rs6987853 0.736 rs2923446 chr8:42404177 G/A cg09913449 chr8:42400586 C8orf40 0.4 9.11 0.34 1.07e-18 Mean corpuscular hemoglobin concentration; BRCA cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA trans rs11039798 0.623 rs594615 chr11:48402804 T/C cg15704280 chr7:45808275 SEPT13 -0.57 -9.65 -0.36 1.14e-20 Axial length; BRCA cis rs250677 0.522 rs919731 chr5:148352150 T/C cg12140854 chr5:148520817 ABLIM3 0.41 8.46 0.32 1.83e-16 Breast cancer; BRCA cis rs6088590 0.965 rs13040449 chr20:33358901 T/A cg24642439 chr20:33292090 TP53INP2 0.71 15.79 0.53 1.16e-47 Coronary artery disease; BRCA cis rs7666738 0.830 rs3846443 chr4:99032666 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.569 rs2924374 chr5:93151141 T/C cg25358565 chr5:93447407 FAM172A -0.66 -11.57 -0.42 3.15e-28 Diabetic retinopathy; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg03188948 chr7:1209495 NA 0.82 11.41 0.41 1.43e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.52 11.21 0.41 9.32e-27 Colorectal cancer; BRCA cis rs7580658 0.545 rs59318157 chr2:127950074 G/C cg16751203 chr2:127950803 CYP27C1 0.29 8.07 0.3 3.55e-15 Protein C levels; BRCA cis rs796364 0.950 rs188146 chr2:200750444 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.67 0.42 1.12e-28 Schizophrenia; BRCA cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg06238570 chr21:40685208 BRWD1 -0.42 -8.65 -0.32 4.03e-17 Cognitive function; BRCA cis rs524281 0.861 rs4013917 chr11:65926185 A/G cg16950941 chr11:66035639 RAB1B -0.37 -7.84 -0.3 1.91e-14 Electroencephalogram traits; BRCA cis rs6867032 0.527 rs1017924 chr5:1976187 C/T cg26168224 chr5:2018326 NA 0.48 11.03 0.4 5e-26 Gut microbiome composition (winter); BRCA cis rs7927771 0.524 rs7933184 chr11:47682402 C/T cg20307385 chr11:47447363 PSMC3 0.43 9.67 0.36 9.81e-21 Subjective well-being; BRCA cis rs1005277 0.602 rs1780141 chr10:38504299 T/C cg00409905 chr10:38381863 ZNF37A -0.53 -11.43 -0.41 1.22e-27 Extrinsic epigenetic age acceleration; BRCA cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg11833968 chr6:79620685 NA -0.42 -9.55 -0.35 2.74e-20 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg10802521 chr3:52805072 NEK4 -0.32 -8.31 -0.31 5.58e-16 Bipolar disorder; BRCA cis rs61931739 0.500 rs6416261 chr12:34540377 T/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.28e-23 Morning vs. evening chronotype; BRCA cis rs1801251 0.752 rs2675966 chr2:233735543 T/C cg08000102 chr2:233561755 GIGYF2 -0.46 -9.99 -0.37 6.34e-22 Coronary artery disease; BRCA cis rs58804349 0.685 rs11239855 chr10:43483879 A/G cg08461752 chr10:43522343 NA 0.64 10.83 0.39 3.18e-25 Pediatric bone mineral content (radius); BRCA cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.31 0.52 2.75e-45 Drug-induced liver injury (flucloxacillin); BRCA cis rs7312933 0.966 rs7977365 chr12:42513127 G/A cg17420585 chr12:42539391 GXYLT1 -0.49 -10.6 -0.39 2.61e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs4363385 0.818 rs1415969 chr1:153006448 G/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.49 -0.32 1.4e-16 Inflammatory skin disease; BRCA cis rs7819412 0.502 rs11777918 chr8:11036919 A/G cg21775007 chr8:11205619 TDH 0.43 8.42 0.32 2.42e-16 Triglycerides; BRCA cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs370915 0.542 rs1425953 chr4:187833652 A/C cg19519643 chr4:187840862 NA -0.36 -8.5 -0.32 1.34e-16 Gout; BRCA cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg05623727 chr3:50126028 RBM5 0.46 8.85 0.33 8.54e-18 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg22337977 chr21:31811175 KRTAP15-1 0.34 7.94 0.3 9.15e-15 HDL cholesterol; BRCA cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.18 0.37 1.16e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6582630 0.555 rs10880613 chr12:38509553 C/T cg26384229 chr12:38710491 ALG10B 0.77 17.67 0.57 3.37e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs7100689 0.577 rs10749560 chr10:82092801 G/T cg00277334 chr10:82204260 NA -0.43 -8.51 -0.32 1.2e-16 Post bronchodilator FEV1; BRCA cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg17971929 chr21:40555470 PSMG1 -0.49 -10.73 -0.39 8.27e-25 Menarche (age at onset); BRCA cis rs1401999 0.836 rs34571027 chr3:183726644 T/C cg01324343 chr3:183735012 ABCC5 0.79 19.65 0.61 1.32e-67 Anterior chamber depth; BRCA cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg11764359 chr7:65958608 NA 0.68 15.24 0.52 5.79e-45 Aortic root size; BRCA cis rs11098499 0.754 rs1546503 chr4:120241167 T/C cg09307838 chr4:120376055 NA 0.64 13.94 0.48 9.61e-39 Corneal astigmatism; BRCA cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg10523679 chr1:76189770 ACADM 0.67 11.98 0.43 5.52e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs8032158 1.000 rs2288344 chr15:56122347 T/G cg02198044 chr15:56286336 NEDD4 -0.38 -9.08 -0.34 1.36e-18 Keloid; BRCA cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.46e-19 Bipolar disorder; BRCA cis rs4074536 0.536 rs6687862 chr1:116289728 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs9368481 1.000 rs9368481 chr6:26961761 C/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.32 -9.63 -0.36 1.43e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs6835098 0.961 rs28709762 chr4:174099149 T/C cg27433088 chr4:174089019 GALNT7 0.33 8.78 0.33 1.54e-17 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs8062405 1.000 rs62036657 chr16:28844365 G/A cg16576597 chr16:28551801 NUPR1 0.3 8.37 0.31 3.53e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1580019 0.587 rs7804457 chr7:32557981 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.14 0.31 2.06e-15 Cognitive ability; BRCA cis rs2243480 0.706 rs34466769 chr7:65453292 A/C cg18876405 chr7:65276391 NA 0.51 7.97 0.3 7.08e-15 Diabetic kidney disease; BRCA cis rs1420338 0.839 rs918036 chr7:34181859 A/G cg01275685 chr7:34179230 BMPER -0.51 -11.35 -0.41 2.45e-27 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA trans rs12310956 0.532 rs11052954 chr12:33993512 C/G cg26384229 chr12:38710491 ALG10B 0.51 10.95 0.4 1.1e-25 Morning vs. evening chronotype; BRCA cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg25173405 chr17:45401733 C17orf57 -0.47 -9.71 -0.36 7e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.81 0.36 2.92e-21 Bipolar disorder; BRCA cis rs11992186 0.597 rs77717027 chr8:8591632 T/C cg15556689 chr8:8085844 FLJ10661 -0.35 -9.22 -0.34 4.29e-19 Neuroticism; BRCA cis rs270601 0.955 rs273911 chr5:131661526 C/G cg11843238 chr5:131593191 PDLIM4 0.36 7.88 0.3 1.39e-14 Acylcarnitine levels; BRCA cis rs9467773 0.572 rs13213953 chr6:26594534 T/A cg11502198 chr6:26597334 ABT1 0.52 9.96 0.37 7.94e-22 Intelligence (multi-trait analysis); BRCA trans rs208520 0.690 rs864314 chr6:66814830 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -38.83 -0.84 2.83e-170 Exhaled nitric oxide output; BRCA cis rs910316 0.663 rs175034 chr14:75463687 T/G cg11812906 chr14:75593930 NEK9 -0.61 -14.13 -0.49 1.21e-39 Height; BRCA cis rs7011049 1.000 rs11993171 chr8:53832898 C/A cg26025543 chr8:53854495 NA 0.55 9.94 0.37 9.57e-22 Systolic blood pressure; BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg00166722 chr3:10149974 C3orf24 0.66 13.26 0.46 1.33e-35 Alzheimer's disease; BRCA cis rs61931739 0.500 rs11053203 chr12:34456593 C/T cg06521331 chr12:34319734 NA -0.56 -10.19 -0.37 1.06e-22 Morning vs. evening chronotype; BRCA cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg26149184 chr10:133730230 NA 0.42 8.25 0.31 8.92e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2836974 0.899 rs68004583 chr21:40659587 T/C cg17971929 chr21:40555470 PSMG1 0.8 19.27 0.61 1.36e-65 Cognitive function; BRCA cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg12011299 chr4:100065546 ADH4 -0.5 -11.53 -0.41 4.55e-28 Alcohol dependence; BRCA cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg21926612 chr6:163149169 PACRG;PARK2 1.04 15.68 0.53 3.87e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7824557 0.767 rs1897950 chr8:11169551 C/A cg21775007 chr8:11205619 TDH 0.62 11.99 0.43 5.23e-30 Retinal vascular caliber; BRCA cis rs9790314 0.695 rs7637086 chr3:160836822 T/C cg03342759 chr3:160939853 NMD3 -0.53 -11.33 -0.41 3.02e-27 Morning vs. evening chronotype; BRCA cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg05896524 chr21:47604654 C21orf56 0.5 9.69 0.36 8.36e-21 Testicular germ cell tumor; BRCA cis rs262150 1.000 rs262150 chr7:158777934 G/A cg19418458 chr7:158789849 NA -0.41 -9.26 -0.34 2.94e-19 Facial morphology (factor 20); BRCA cis rs12210905 0.688 rs114157955 chr6:27329878 C/T cg08851530 chr6:28072375 NA 0.91 8.7 0.33 2.7e-17 Hip circumference adjusted for BMI; BRCA cis rs858239 0.600 rs7776644 chr7:23119307 C/T cg23682824 chr7:23144976 KLHL7 0.44 11.45 0.41 9.84e-28 Cerebrospinal fluid biomarker levels; BRCA cis rs796364 0.951 rs7608668 chr2:201000017 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.48 -8.67 -0.32 3.53e-17 Schizophrenia; BRCA cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.89e-18 Motion sickness; BRCA cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg18132916 chr6:79620363 NA -0.39 -8.09 -0.3 3.05e-15 Intelligence (multi-trait analysis); BRCA cis rs910316 1.000 rs175449 chr14:75590846 A/T cg23033748 chr14:75592666 NEK9 -0.43 -10.61 -0.39 2.43e-24 Height; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg09177884 chr7:1199841 ZFAND2A -0.5 -10.7 -0.39 1.09e-24 Longevity;Endometriosis; BRCA cis rs4713118 0.662 rs9468277 chr6:28028390 C/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.29 0.31 6.9e-16 Parkinson's disease; BRCA cis rs17685 0.712 rs6954569 chr7:75738885 T/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.57 -0.35 2.2e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs12541635 0.677 rs6469032 chr8:107057509 A/T cg10147462 chr8:107024639 NA 0.41 10.89 0.4 1.89e-25 Age of smoking initiation; BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg14863265 chr7:2801509 GNA12 -0.46 -10.07 -0.37 3.06e-22 Height; BRCA cis rs7727544 0.684 rs2631363 chr5:131707095 A/G cg24060327 chr5:131705240 SLC22A5 0.46 9.44 0.35 7.06e-20 Blood metabolite levels; BRCA cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg00409905 chr10:38381863 ZNF37A -0.49 -10.29 -0.38 4.59e-23 Extrinsic epigenetic age acceleration; BRCA cis rs6723226 0.772 rs2366894 chr2:32713706 A/T cg02381751 chr2:32503542 YIPF4 0.69 15.25 0.52 5.11e-45 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg05283184 chr6:79620031 NA -0.43 -11.03 -0.4 4.97e-26 Intelligence (multi-trait analysis); BRCA cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg04972856 chr6:88032051 C6orf162;GJB7 -0.32 -8.7 -0.33 2.78e-17 Monocyte percentage of white cells; BRCA cis rs7617773 0.780 rs35297395 chr3:48342882 C/T cg11946769 chr3:48343235 NME6 0.68 13.79 0.48 4.87e-38 Coronary artery disease; BRCA cis rs3916 0.911 rs7313271 chr12:121152667 C/T cg21892295 chr12:121157589 UNC119B -0.38 -9.78 -0.36 3.69e-21 Urinary metabolites (H-NMR features); BRCA cis rs66887589 0.934 rs4834792 chr4:120555696 T/A cg09307838 chr4:120376055 NA -0.44 -9.14 -0.34 8.1e-19 Diastolic blood pressure; BRCA trans rs1005277 0.522 rs289649 chr10:37975384 T/C cg17830980 chr10:43048298 ZNF37B -0.42 -9.9 -0.36 1.38e-21 Extrinsic epigenetic age acceleration; BRCA cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg22117172 chr7:91764530 CYP51A1 0.23 7.99 0.3 6.46e-15 Breast cancer; BRCA cis rs6582630 0.519 rs11514372 chr12:38308613 T/G cg13010199 chr12:38710504 ALG10B 0.5 10.33 0.38 2.96e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs13191362 1.000 rs34637087 chr6:163004064 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.07e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs208520 0.608 rs3846803 chr6:66805743 C/A cg07460842 chr6:66804631 NA -1.0 -20.11 -0.62 4.5e-70 Exhaled nitric oxide output; BRCA cis rs11718455 0.960 rs13082990 chr3:44005172 T/C cg08738300 chr3:44038990 NA 0.47 8.85 0.33 8.52e-18 Coronary artery disease; BRCA cis rs10499694 1.000 rs10499694 chr7:50614173 A/G cg18232548 chr7:50535776 DDC -0.36 -9.01 -0.34 2.34e-18 Body mass index; BRCA cis rs4713118 0.513 rs156739 chr6:28013410 C/A cg10876282 chr6:28092338 ZSCAN16 0.41 7.95 0.3 8.43e-15 Parkinson's disease; BRCA cis rs9467773 0.620 rs2451731 chr6:26624822 A/C cg09904177 chr6:26538194 HMGN4 0.47 14.72 0.5 1.88e-42 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.78 -0.42 3.93e-29 Bipolar disorder; BRCA cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg08048268 chr3:133502702 NA 0.43 11.22 0.41 8.37e-27 Iron status biomarkers; BRCA cis rs61931739 0.500 rs11053217 chr12:34470036 A/C cg06521331 chr12:34319734 NA -0.52 -10.22 -0.37 8.04e-23 Morning vs. evening chronotype; BRCA cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.81 -0.33 1.15e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2506889 0.553 rs17035189 chr1:10597024 A/G cg17425144 chr1:10567563 PEX14 0.56 14.31 0.49 1.75e-40 Breast cancer; BRCA cis rs9462027 0.628 rs7756405 chr6:34722659 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.37e-15 Systemic lupus erythematosus; BRCA cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.9 14.11 0.49 1.47e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1799922 0.684 rs339095 chr7:128406047 C/G cg02354431 chr7:128423266 NA 0.31 7.97 0.3 7.46e-15 Primary tooth development (number of teeth);Primary tooth development (time to first tooth eruption); BRCA cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg07606381 chr6:8435919 SLC35B3 0.66 14.42 0.5 5.25e-41 Motion sickness; BRCA cis rs9463078 0.665 rs9472339 chr6:44711791 A/G cg25276700 chr6:44698697 NA 0.37 8.57 0.32 7.53e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs2797160 1.000 rs1832980 chr6:125997444 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.88 -0.3 1.41e-14 Endometrial cancer; BRCA cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg11764359 chr7:65958608 NA 0.74 16.65 0.55 5.68e-52 Aortic root size; BRCA trans rs11722228 0.522 rs1109472 chr4:10134448 C/G cg26043149 chr18:55253948 FECH 1.02 25.1 0.7 2.66e-97 Gout;Urate levels;Serum uric acid levels; BRCA cis rs1153858 0.943 rs4774580 chr15:45652086 G/A cg21132104 chr15:45694354 SPATA5L1 0.74 16.77 0.55 1.47e-52 Homoarginine levels; BRCA cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg01579765 chr21:45077557 HSF2BP -0.35 -9.67 -0.36 9.63e-21 Mean corpuscular volume; BRCA cis rs7560272 0.501 rs11126417 chr2:73974315 A/G cg20560298 chr2:73613845 ALMS1 -0.34 -8.57 -0.32 7.58e-17 Schizophrenia; BRCA trans rs2832077 1.000 rs2832077 chr21:30141021 G/A cg14791747 chr16:20752902 THUMPD1 0.4 9.67 0.36 1.01e-20 Cognitive test performance; BRCA cis rs2742234 1.000 rs1864399 chr10:43610455 T/C cg02780029 chr10:43622663 RET -0.42 -10.36 -0.38 2.39e-23 Hirschsprung disease; BRCA cis rs62380364 0.542 rs2247885 chr5:88047999 T/C cg22951263 chr5:87985283 NA -0.39 -10.82 -0.39 3.58e-25 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -9.25 -0.34 3.25e-19 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 22.78 0.67 1.57e-84 Chronic sinus infection; BRCA cis rs12611088 0.602 rs6509092 chr19:44022305 A/T cg15012607 chr19:44012195 ETHE1 -0.35 -9.02 -0.34 2.09e-18 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs1065852 0.526 rs12166549 chr22:42410419 T/C cg22189786 chr22:42395067 WBP2NL 0.41 8.11 0.31 2.64e-15 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 19.69 0.61 7.86e-68 Platelet count; BRCA cis rs6088580 0.634 rs6059835 chr20:33020141 A/G cg24642439 chr20:33292090 TP53INP2 0.54 11.77 0.42 4.61e-29 Glomerular filtration rate (creatinine); BRCA cis rs1475911 0.708 rs11701371 chr21:43523972 C/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.94 20.94 0.64 1.61e-74 IgG glycosylation; BRCA cis rs7246657 0.943 rs1015849 chr19:37946180 G/A cg18154014 chr19:37997991 ZNF793 0.62 11.66 0.42 1.31e-28 Coronary artery calcification; BRCA cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg22467129 chr15:76604101 ETFA -0.41 -9.02 -0.34 2.09e-18 Blood metabolite levels; BRCA cis rs4242434 0.927 rs720746 chr8:22471399 T/C cg03733263 chr8:22462867 KIAA1967 1.04 24.53 0.7 3.77e-94 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs9814567 0.896 rs4245907 chr3:134347876 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.38 -0.31 3.41e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg01448562 chr3:133502909 NA -0.62 -14.61 -0.5 6.43e-42 Iron status biomarkers; BRCA cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.41 -8.79 -0.33 1.43e-17 IgG glycosylation; BRCA cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg21535247 chr6:8435926 SLC35B3 0.41 9.38 0.35 1.09e-19 Motion sickness; BRCA cis rs12142240 0.698 rs17361915 chr1:46847321 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.69 -0.36 8.4e-21 Menopause (age at onset); BRCA cis rs826838 0.967 rs7136593 chr12:39128265 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs8114671 0.562 rs3746450 chr20:33508588 G/T cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.03e-18 Height; BRCA cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg03433033 chr1:76189801 ACADM -0.59 -11.61 -0.42 2.08e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs909002 0.819 rs2292989 chr1:32135773 A/G cg13919466 chr1:32135498 COL16A1 0.25 8.57 0.32 7.93e-17 Intelligence (multi-trait analysis); BRCA cis rs13631 0.965 rs7853589 chr9:140003844 A/G cg03717367 chr9:139980219 LOC100289341;MAN1B1 -0.39 -9.27 -0.34 2.75e-19 Cerebrospinal fluid biomarker levels; BRCA cis rs9527 0.662 rs4919686 chr10:104592249 A/C cg04362960 chr10:104952993 NT5C2 0.44 8.67 0.32 3.47e-17 Arsenic metabolism; BRCA cis rs1113500 0.933 rs11185260 chr1:108635079 A/T cg06207961 chr1:108661230 NA -0.44 -10.73 -0.39 8.23e-25 Growth-regulated protein alpha levels; BRCA cis rs13256369 1.000 rs4841016 chr8:8572561 C/T cg06671706 chr8:8559999 CLDN23 0.43 8.34 0.31 4.64e-16 Obesity-related traits; BRCA cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.12e-26 Extrinsic epigenetic age acceleration; BRCA cis rs9467773 1.000 rs9986382 chr6:26550619 T/C cg09904177 chr6:26538194 HMGN4 0.55 17.8 0.58 7.39e-58 Intelligence (multi-trait analysis); BRCA cis rs9393692 0.905 rs7747133 chr6:26293470 C/T cg00631329 chr6:26305371 NA -0.43 -12.91 -0.45 4.96e-34 Educational attainment; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg05896524 chr21:47604654 C21orf56 -0.5 -9.8 -0.36 3.31e-21 Testicular germ cell tumor; BRCA cis rs2880765 0.835 rs900573 chr15:86037993 G/T cg10818794 chr15:86012489 AKAP13 0.3 8.53 0.32 1.04e-16 Coronary artery disease; BRCA cis rs72799341 1.000 rs1458201 chr16:30916129 G/A cg02466173 chr16:30829666 NA -0.48 -9.0 -0.34 2.62e-18 Diastolic blood pressure; BRCA cis rs7178424 1.000 rs7177711 chr15:62379971 A/G cg00456672 chr15:62358751 C2CD4A -0.34 -8.13 -0.31 2.25e-15 Height; BRCA cis rs8005677 1.000 rs7145494 chr14:23399790 T/C cg01529538 chr14:23388837 RBM23 0.41 11.12 0.4 2.25e-26 Cognitive ability (multi-trait analysis); BRCA cis rs7572733 0.576 rs1368989 chr2:198937082 T/C cg00792783 chr2:198669748 PLCL1 0.36 7.91 0.3 1.15e-14 Dermatomyositis; BRCA cis rs9837602 1.000 rs35669453 chr3:99766063 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.29e-26 Breast cancer; BRCA cis rs9811920 0.609 rs793463 chr3:99620252 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.89 0.3 1.33e-14 Axial length; BRCA cis rs7903847 0.642 rs7909345 chr10:99150794 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.78 -0.33 1.53e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.85 -0.3 1.77e-14 Axial length; BRCA cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.47 9.75 0.36 4.75e-21 Tonsillectomy; BRCA cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg09184832 chr6:79620586 NA -0.5 -11.22 -0.41 8.91e-27 Intelligence (multi-trait analysis); BRCA cis rs875971 1.000 rs6460296 chr7:65895139 C/T cg18876405 chr7:65276391 NA 0.55 13.17 0.46 3.21e-35 Aortic root size; BRCA cis rs875971 0.543 rs801191 chr7:66032955 G/A cg11764359 chr7:65958608 NA -0.63 -13.48 -0.47 1.2e-36 Aortic root size; BRCA cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg22535103 chr8:58192502 C8orf71 -0.61 -13.17 -0.46 3.08e-35 Developmental language disorder (linguistic errors); BRCA cis rs3733585 0.699 rs12498150 chr4:9950537 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.33 -0.38 3.1e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg26384229 chr12:38710491 ALG10B 0.76 17.01 0.56 8.48e-54 Morning vs. evening chronotype; BRCA cis rs9341808 0.935 rs1535825 chr6:80938586 C/T cg08355045 chr6:80787529 NA -0.34 -8.82 -0.33 1.05e-17 Sitting height ratio; BRCA cis rs17270561 0.609 rs9358884 chr6:25756592 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.7 0.33 2.82e-17 Iron status biomarkers; BRCA cis rs6121246 0.609 rs2149281 chr20:30417918 G/A cg13852791 chr20:30311386 BCL2L1 0.88 20.0 0.62 1.72e-69 Mean corpuscular hemoglobin; BRCA cis rs6964587 1.000 rs12540565 chr7:91633213 T/G cg17063962 chr7:91808500 NA 0.52 12.35 0.44 1.39e-31 Breast cancer; BRCA cis rs7246657 0.943 rs10422074 chr19:37894236 T/C cg23950597 chr19:37808831 NA -0.75 -13.13 -0.46 4.8e-35 Coronary artery calcification; BRCA cis rs701145 0.585 rs959376 chr3:153866707 A/T cg17054900 chr3:154042577 DHX36 0.44 8.24 0.31 9.99e-16 Coronary artery disease; BRCA cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA trans rs7647973 0.626 rs4855833 chr3:49657441 A/G cg21659725 chr3:3221576 CRBN -0.47 -8.66 -0.32 3.84e-17 Menarche (age at onset); BRCA cis rs62229266 0.771 rs62230790 chr21:37388911 A/G cg12218747 chr21:37451666 NA -0.34 -8.01 -0.3 5.59e-15 Mitral valve prolapse; BRCA cis rs10782582 0.569 rs74090722 chr1:76197262 A/G cg03433033 chr1:76189801 ACADM -0.5 -10.6 -0.39 2.78e-24 Daytime sleep phenotypes; BRCA cis rs703842 0.928 rs724834 chr12:58180416 G/C cg18357645 chr12:58087776 OS9 -0.34 -8.24 -0.31 9.51e-16 Multiple sclerosis; BRCA cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg03433033 chr1:76189801 ACADM 0.68 12.54 0.44 2.14e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7264396 0.563 rs2425111 chr20:34319765 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.21 -0.43 6e-31 Total cholesterol levels; BRCA cis rs11148252 0.846 rs7985262 chr13:52997161 C/T cg00495681 chr13:53174319 NA 0.41 8.61 0.32 5.48e-17 Lewy body disease; BRCA cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 12.93 0.46 3.7e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4690686 0.500 rs4690429 chr4:177263983 G/A cg17059388 chr4:177262070 NA 0.51 10.68 0.39 1.34e-24 Essential tremor; BRCA cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg23283495 chr1:209979779 IRF6 0.38 8.88 0.33 6.55e-18 Cleft lip with or without cleft palate; BRCA trans rs17685 0.753 rs55812043 chr7:75747241 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.61 0.74 4.43e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg27170947 chr2:26402098 FAM59B -0.98 -17.25 -0.56 4.73e-55 Gut microbiome composition (summer); BRCA cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg10556349 chr10:835070 NA 0.59 8.31 0.31 5.59e-16 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.65 0.71 2.54e-100 Chronic sinus infection; BRCA cis rs2070488 0.932 rs1841776 chr3:38480727 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 20.34 0.63 2.86e-71 Electrocardiographic conduction measures; BRCA cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg12310025 chr6:25882481 NA -0.54 -13.07 -0.46 9.5e-35 Blood metabolite levels; BRCA cis rs68170813 0.559 rs113211438 chr7:106969198 G/A cg02696742 chr7:106810147 HBP1 -0.55 -8.92 -0.33 4.99e-18 Coronary artery disease; BRCA trans rs747782 0.528 rs11039674 chr11:48336116 C/T cg15704280 chr7:45808275 SEPT13 0.54 8.19 0.31 1.43e-15 Intraocular pressure; BRCA cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg18230493 chr5:56204884 C5orf35 -0.62 -13.37 -0.47 4.03e-36 Initial pursuit acceleration; BRCA cis rs4727027 0.901 rs34201592 chr7:148842403 C/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.79 0.33 1.39e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9486715 0.838 rs7452350 chr6:96883326 C/A cg06623918 chr6:96969491 KIAA0776 0.9 25.54 0.71 1.14e-99 Headache; BRCA cis rs9715521 0.645 rs13134207 chr4:59848379 G/T cg11281224 chr4:60001000 NA -0.35 -7.88 -0.3 1.43e-14 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg08807101 chr21:30365312 RNF160 0.56 11.89 0.43 1.41e-29 Selective IgA deficiency; BRCA cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg22105103 chr4:187893119 NA 0.42 13.5 0.47 1e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.713 rs2328704 chr6:146020494 T/C cg23711669 chr6:146136114 FBXO30 -0.69 -16.63 -0.55 7.2e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg18402987 chr7:1209562 NA 0.82 11.85 0.42 1.95e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg15704280 chr7:45808275 SEPT13 -0.53 -10.33 -0.38 2.95e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs681343 1.000 rs679574 chr19:49206108 C/G cg21064579 chr19:49206444 FUT2 0.37 9.34 0.35 1.62e-19 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs477692 0.563 rs7079165 chr10:131430240 G/A cg24747557 chr10:131355152 MGMT 0.37 9.32 0.35 1.87e-19 Response to temozolomide; BRCA cis rs7666738 0.657 rs13102002 chr4:98617794 T/C cg05340658 chr4:99064831 C4orf37 0.51 8.3 0.31 6.19e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg06627628 chr2:24431161 ITSN2 -0.83 -15.41 -0.52 8.37e-46 Asthma; BRCA cis rs6545883 0.503 rs1665272 chr2:61379286 A/C cg15711740 chr2:61764176 XPO1 -0.44 -11.03 -0.4 5.28e-26 Tuberculosis; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg25036284 chr2:26402008 FAM59B 0.94 15.84 0.53 6.66e-48 Gut microbiome composition (summer); BRCA cis rs4642101 0.737 rs9877165 chr3:12828497 C/T cg24848339 chr3:12840334 CAND2 0.43 11.4 0.41 1.51e-27 QRS complex (12-leadsum); BRCA cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -9.43 -0.35 7.63e-20 Intelligence (multi-trait analysis); BRCA trans rs561341 1.000 rs15654 chr17:30326360 A/C cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.28e-27 Hip circumference adjusted for BMI; BRCA cis rs7552404 0.731 rs10873787 chr1:76367797 G/A cg10523679 chr1:76189770 ACADM 0.7 12.24 0.44 4.12e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg06784218 chr1:46089804 CCDC17 -0.53 -12.82 -0.45 1.24e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.967 rs6762645 chr3:160948349 T/G cg03342759 chr3:160939853 NMD3 -0.63 -13.4 -0.47 2.93e-36 Morning vs. evening chronotype; BRCA cis rs6815814 0.950 rs5743580 chr4:38804405 C/T cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA trans rs60843830 1.000 rs4497901 chr2:239969 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.62 13.87 0.48 2.06e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs77956314 0.515 rs60940473 chr12:117462582 C/T cg23895963 chr12:117471115 NA -0.53 -9.36 -0.35 1.38e-19 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs2046867 0.818 rs62249866 chr3:72878632 T/C cg25664220 chr3:72788482 NA -0.54 -11.64 -0.42 1.6e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs1843834 0.505 rs4674911 chr2:225345254 A/G cg12698349 chr2:225449008 CUL3 0.6 13.3 0.47 8.71e-36 IgE levels in asthmatics (D.p. specific); BRCA cis rs10751667 0.600 rs10902266 chr11:1005697 G/T cg01483505 chr11:975446 AP2A2 0.3 7.96 0.3 7.96e-15 Alzheimer's disease (late onset); BRCA cis rs11971779 0.680 rs6467846 chr7:139079385 G/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA trans rs1459104 1.000 rs12575696 chr11:55057235 C/T cg15704280 chr7:45808275 SEPT13 0.69 8.63 0.32 4.7e-17 Body mass index; BRCA cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.33 -9.98 -0.37 6.82e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg25358565 chr5:93447407 FAM172A 1.03 16.45 0.55 6.03e-51 Diabetic retinopathy; BRCA cis rs9790314 1.000 rs4350933 chr3:160955879 G/T cg04691961 chr3:161091175 C3orf57 -0.51 -12.81 -0.45 1.33e-33 Morning vs. evening chronotype; BRCA cis rs3768617 0.677 rs12739316 chr1:183052080 G/A ch.1.3577855R chr1:183094577 LAMC1 0.48 11.18 0.4 1.27e-26 Fuchs's corneal dystrophy; BRCA cis rs7584330 0.666 rs7600317 chr2:238353513 C/T cg14458575 chr2:238380390 NA 0.58 12.91 0.45 4.67e-34 Prostate cancer; BRCA cis rs67981189 0.896 rs8012728 chr14:71447948 T/C cg15816911 chr14:71606274 NA 0.35 7.83 0.3 2.02e-14 Schizophrenia; BRCA cis rs7089973 0.604 rs2181563 chr10:116604344 T/C cg23260525 chr10:116636907 FAM160B1 0.32 8.34 0.31 4.62e-16 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs701145 0.556 rs355779 chr3:153977253 T/C cg16511985 chr3:153974050 SGEF 0.46 10.63 0.39 2e-24 Coronary artery disease; BRCA cis rs7551345 0.653 rs2889713 chr1:31697751 A/G cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA cis rs1580019 0.520 rs13228793 chr7:32711465 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.45 8.62 0.32 5.21e-17 Cognitive ability; BRCA cis rs4478858 0.684 rs16865957 chr1:31753353 G/A cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs244731 0.959 rs7721671 chr5:176630984 A/G cg06060754 chr5:176797920 RGS14 -0.66 -10.42 -0.38 1.43e-23 Urate levels in lean individuals; BRCA cis rs4901869 0.902 rs2162491 chr14:59296247 C/T cg02291164 chr14:59296302 NA 0.32 8.75 0.33 1.83e-17 Panic disorder; BRCA cis rs708547 0.647 rs781666 chr4:57830981 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.55 0.35 2.61e-20 Response to bleomycin (chromatid breaks); BRCA cis rs7267979 1.000 rs761025 chr20:25426968 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.32 9.05 0.34 1.65e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6866344 0.570 rs11740283 chr5:178136440 T/C cg10224037 chr5:178157518 ZNF354A 0.79 18.21 0.58 5.28e-60 Neutrophil percentage of white cells; BRCA cis rs8114671 0.562 rs1018447 chr20:33401707 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -8.73 -0.33 2.14e-17 Height; BRCA cis rs9443189 0.615 rs602873 chr6:76323818 T/A cg01950844 chr6:76311363 SENP6 0.85 13.82 0.48 3.24e-38 Prostate cancer; BRCA cis rs208520 0.874 rs208515 chr6:66945749 A/G cg07460842 chr6:66804631 NA -0.89 -15.83 -0.53 7.13e-48 Exhaled nitric oxide output; BRCA cis rs7917772 0.536 rs3961456 chr10:104425304 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.58 -15.46 -0.52 5.06e-46 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.77e-26 Extrinsic epigenetic age acceleration; BRCA cis rs17401966 1.000 rs12132635 chr1:10430479 G/A cg03954927 chr1:10346856 KIF1B 0.45 12.47 0.44 4.43e-32 Hepatocellular carcinoma; BRCA cis rs7945705 0.747 rs1980428 chr11:9010497 A/G cg12365402 chr11:9010492 NRIP3 0.4 9.37 0.35 1.18e-19 Hemoglobin concentration; BRCA cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.34e-16 Colorectal cancer; BRCA cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg15556689 chr8:8085844 FLJ10661 -0.33 -8.81 -0.33 1.19e-17 Joint mobility (Beighton score); BRCA cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg08085267 chr17:45401833 C17orf57 -0.67 -14.89 -0.51 3e-43 Multiple sclerosis;Ankylosing spondylitis; BRCA cis rs10504073 0.545 rs4406405 chr8:49957261 G/C cg00325661 chr8:49890786 NA 0.49 14.07 0.49 2.32e-39 Blood metabolite ratios; BRCA cis rs7100689 0.646 rs1290317 chr10:82062531 C/A cg01528321 chr10:82214614 TSPAN14 0.79 16.67 0.55 4.64e-52 Post bronchodilator FEV1; BRCA cis rs6598955 0.585 rs11577098 chr1:26602525 C/T cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg23708337 chr7:1209742 NA 0.63 8.84 0.33 8.9e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4148883 0.689 rs1869458 chr4:100024728 C/G cg13256891 chr4:100009986 ADH5 0.4 8.45 0.32 1.94e-16 Alcohol dependence; BRCA cis rs3806843 0.735 rs2530241 chr5:140054485 C/T cg26395211 chr5:140044315 WDR55 0.38 8.62 0.32 5.29e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs9811920 0.732 rs7613864 chr3:99602470 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.57 13.87 0.48 1.9e-38 Axial length; BRCA trans rs7647973 0.593 rs28535523 chr3:49848414 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.38 7.96 0.3 7.64e-15 Menarche (age at onset); BRCA cis rs897984 0.684 rs6950 chr16:30995669 T/C cg02466173 chr16:30829666 NA 0.49 11.26 0.41 5.97e-27 Dementia with Lewy bodies; BRCA cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg10802521 chr3:52805072 NEK4 -0.34 -9.3 -0.35 2.21e-19 Electroencephalogram traits; BRCA cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 10.01 0.37 5.23e-22 Tonsillectomy; BRCA trans rs2204008 0.652 rs11513964 chr12:37998214 C/G cg06521331 chr12:34319734 NA -0.53 -9.61 -0.36 1.57e-20 Bladder cancer; BRCA trans rs11098499 0.954 rs13133522 chr4:120324424 A/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA cis rs17023223 0.537 rs4590715 chr1:119750201 C/T cg05756136 chr1:119680316 WARS2 -0.42 -7.86 -0.3 1.59e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs11098499 0.954 rs28685688 chr4:120420334 T/C cg09307838 chr4:120376055 NA 0.72 15.24 0.52 5.6e-45 Corneal astigmatism; BRCA cis rs2842992 0.915 rs1967802 chr6:160097791 G/A cg11366901 chr6:160182831 ACAT2 0.78 14.93 0.51 1.95e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs61931739 0.500 rs7979769 chr12:34509522 C/T cg06521331 chr12:34319734 NA -0.56 -10.0 -0.37 5.64e-22 Morning vs. evening chronotype; BRCA trans rs11039798 0.507 rs56994343 chr11:48896970 G/A cg15704280 chr7:45808275 SEPT13 0.62 10.42 0.38 1.41e-23 Axial length; BRCA cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.84 0.36 2.34e-21 Bipolar disorder; BRCA cis rs9486715 0.838 rs6928442 chr6:96870118 A/G cg06623918 chr6:96969491 KIAA0776 0.9 25.49 0.71 1.97e-99 Headache; BRCA cis rs10504229 0.683 rs16921810 chr8:58106067 A/G cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg23173402 chr1:227635558 NA 0.44 8.16 0.31 1.81e-15 Major depressive disorder; BRCA cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg05714579 chr10:131428358 MGMT 0.5 11.03 0.4 4.95e-26 Response to temozolomide; BRCA cis rs8180040 1.000 rs553989 chr3:47400328 A/G cg16586182 chr3:47516702 SCAP 0.6 14.02 0.49 3.9e-39 Colorectal cancer; BRCA cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg20476274 chr7:133979776 SLC35B4 0.5 11.77 0.42 4.24e-29 Mean platelet volume; BRCA cis rs7666738 0.512 rs165251 chr4:98758490 C/G cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2797160 0.651 rs1269176 chr6:126029682 A/T cg05901451 chr6:126070800 HEY2 -0.43 -10.85 -0.39 2.62e-25 Endometrial cancer; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.05 21.9 0.65 9.95e-80 Gut microbiome composition (summer); BRCA cis rs7523273 0.568 rs1318653 chr1:208014922 C/T cg22525895 chr1:207977042 MIR29B2 0.4 8.23 0.31 1.05e-15 Schizophrenia; BRCA cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7772486 0.719 rs4391282 chr6:146276780 A/T cg23711669 chr6:146136114 FBXO30 -0.68 -15.76 -0.53 1.54e-47 Lobe attachment (rater-scored or self-reported); BRCA trans rs7618501 1.000 rs7618519 chr3:49772708 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.53 -16.69 -0.55 3.62e-52 Intelligence (multi-trait analysis); BRCA cis rs7575217 0.697 rs2582930 chr2:101721369 T/A cg23907051 chr2:101730305 TBC1D8 -0.2 -7.9 -0.3 1.22e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs2806561 0.929 rs9426694 chr1:23539742 T/C cg19743168 chr1:23544995 NA 0.46 11.45 0.41 9.37e-28 Height; BRCA cis rs4466137 0.909 rs4466136 chr5:82985576 T/G cg15083037 chr5:83017644 HAPLN1 -0.51 -10.12 -0.37 2.02e-22 Prostate cancer; BRCA cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg24596788 chr1:163392923 NA -0.37 -9.9 -0.36 1.3e-21 Motion sickness; BRCA cis rs2559856 1.000 rs2559857 chr12:102089399 A/C cg12213457 chr12:102090980 CHPT1 -0.36 -7.81 -0.3 2.32e-14 Blood protein levels; BRCA cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg17971929 chr21:40555470 PSMG1 0.77 18.05 0.58 3.77e-59 Cognitive function; BRCA cis rs262150 0.502 rs73167295 chr7:158782949 T/A cg17987982 chr7:158820591 NA -0.43 -8.15 -0.31 1.87e-15 Facial morphology (factor 20); BRCA cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17261708 chr5:176794207 RGS14 -0.39 -8.44 -0.32 2.08e-16 Hemoglobin concentration;Hematocrit; BRCA cis rs804280 0.662 rs11250164 chr8:11610686 C/T cg26752888 chr8:11627280 NEIL2 0.43 9.03 0.34 1.94e-18 Myopia (pathological); BRCA cis rs60871478 1.000 rs4720917 chr7:806998 C/G cg04727924 chr7:799746 HEATR2 -0.55 -10.82 -0.39 3.66e-25 Cerebrospinal P-tau181p levels; BRCA cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg06484146 chr7:12443880 VWDE -0.78 -11.09 -0.4 3.03e-26 Coronary artery disease; BRCA cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg05868516 chr6:26286170 HIST1H4H 0.5 11.3 0.41 4e-27 Educational attainment; BRCA cis rs9399135 0.967 rs45544135 chr6:135324051 T/C cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 9.12e-33 Red blood cell count; BRCA cis rs6725517 0.737 rs7576788 chr2:25083310 A/G cg04586622 chr2:25135609 ADCY3 0.39 10.08 0.37 2.9e-22 Breast cancer; BRCA cis rs929596 1.000 rs929596 chr2:234674476 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.44 -11.0 -0.4 7.05e-26 Total bilirubin levels in HIV-1 infection; BRCA cis rs644148 0.933 rs565819 chr19:44967714 A/G cg15540054 chr19:45004280 ZNF180 0.56 11.87 0.43 1.6e-29 Personality dimensions; BRCA cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11890956 chr21:40555474 PSMG1 -0.61 -13.62 -0.47 2.88e-37 Menarche (age at onset); BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg11814155 chr7:99998594 ZCWPW1 0.46 8.22 0.31 1.16e-15 Platelet count; BRCA cis rs7512552 0.839 rs11581351 chr1:150440200 G/C cg15654264 chr1:150340011 RPRD2 0.4 8.55 0.32 8.74e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7737355 0.812 rs6868007 chr5:130824810 T/C cg06307176 chr5:131281290 NA 0.48 10.48 0.38 7.88e-24 Life satisfaction; BRCA cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg00071950 chr4:10020882 SLC2A9 -0.49 -11.74 -0.42 5.81e-29 Bone mineral density; BRCA cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg01028140 chr2:1542097 TPO -0.56 -11.48 -0.41 7.52e-28 IgG glycosylation; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -8.81 -0.33 1.21e-17 Bipolar disorder and schizophrenia; BRCA cis rs1801251 0.963 rs35362030 chr2:233612845 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.39 0.41 1.76e-27 Coronary artery disease; BRCA cis rs10754283 0.756 rs17441836 chr1:90135433 C/T cg21401794 chr1:90099060 LRRC8C 0.41 9.4 0.35 9.66e-20 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg17691542 chr6:26056736 HIST1H1C 0.47 9.59 0.35 1.92e-20 Height; BRCA trans rs2727020 0.894 rs10839265 chr11:49369733 C/T cg15704280 chr7:45808275 SEPT13 -0.73 -14.95 -0.51 1.48e-43 Coronary artery disease; BRCA cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg12923728 chr3:195709715 SDHAP1 -0.53 -9.17 -0.34 6.47e-19 Pancreatic cancer; BRCA trans rs2204008 0.837 rs8189467 chr12:38241956 T/C cg06521331 chr12:34319734 NA -0.52 -9.81 -0.36 2.88e-21 Bladder cancer; BRCA cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg27165867 chr14:105738592 BRF1 -0.35 -8.18 -0.31 1.54e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs68170813 0.559 rs11769861 chr7:106979559 T/C cg02696742 chr7:106810147 HBP1 -0.55 -8.79 -0.33 1.4e-17 Coronary artery disease; BRCA cis rs7640424 0.784 rs68044584 chr3:107845395 A/G cg09227934 chr3:107805635 CD47 -0.43 -8.95 -0.33 3.9e-18 Body mass index; BRCA cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg03146154 chr1:46216737 IPP 0.47 10.52 0.38 5.5e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9487051 0.735 rs882074 chr6:109611720 C/T cg21918786 chr6:109611834 NA -0.49 -14.14 -0.49 1.13e-39 Reticulocyte fraction of red cells; BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg18230493 chr5:56204884 C5orf35 -0.75 -14.2 -0.49 5.87e-40 Initial pursuit acceleration; BRCA cis rs7552404 0.727 rs7547508 chr1:76327958 A/G cg03433033 chr1:76189801 ACADM -0.6 -12.15 -0.43 1.08e-30 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs9467711 0.606 rs9366656 chr6:26434630 T/C cg01620082 chr3:125678407 NA -0.64 -8.56 -0.32 8.69e-17 Autism spectrum disorder or schizophrenia; BRCA trans rs12517041 0.935 rs35858834 chr5:23325233 A/T ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.2 -0.31 1.29e-15 Calcium levels; BRCA cis rs7927771 0.832 rs1542321 chr11:47379615 G/A cg20307385 chr11:47447363 PSMC3 0.41 8.57 0.32 7.7e-17 Subjective well-being; BRCA cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.25e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07343612 chr16:622815 PIGQ -0.68 -22.83 -0.67 8.65e-85 Height; BRCA cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg01858014 chr14:56050164 KTN1 -0.73 -10.81 -0.39 3.79e-25 Putamen volume; BRCA cis rs208520 1.000 rs72884033 chr6:66995747 T/C cg07460842 chr6:66804631 NA 0.88 14.14 0.49 1.11e-39 Exhaled nitric oxide output; BRCA cis rs870825 0.616 rs28582728 chr4:185646920 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg19920283 chr7:105172520 RINT1 0.61 9.53 0.35 3.16e-20 Bipolar disorder (body mass index interaction); BRCA cis rs708547 0.647 rs1626594 chr4:57878254 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.82 0.36 2.67e-21 Response to bleomycin (chromatid breaks); BRCA trans rs61931739 0.500 rs11052966 chr12:34019826 C/T cg26384229 chr12:38710491 ALG10B 0.51 10.95 0.4 1.13e-25 Morning vs. evening chronotype; BRCA cis rs9527 0.590 rs10883834 chr10:104881402 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA cis rs2882667 0.690 rs825769 chr5:138115355 G/A cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7937682 0.961 rs17113227 chr11:111620491 A/G cg09085632 chr11:111637200 PPP2R1B -0.98 -23.3 -0.68 2.16e-87 Primary sclerosing cholangitis; BRCA cis rs2882667 0.898 rs2351465 chr5:138363851 A/C cg04439458 chr5:138467593 SIL1 -0.32 -8.87 -0.33 7.33e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg11766577 chr21:47581405 C21orf56 -0.44 -9.72 -0.36 6.44e-21 Testicular germ cell tumor; BRCA cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.8599999999999993e-24 Motion sickness; BRCA cis rs2243480 1.000 rs937108 chr7:65428452 G/A cg18252515 chr7:66147081 NA -0.83 -12.11 -0.43 1.49e-30 Diabetic kidney disease; BRCA cis rs12369179 0.737 rs116896792 chr12:122948907 T/C cg18578876 chr12:123200353 GPR109B -1.35 -15.69 -0.53 3.67e-47 Age-related diseases, mortality and associated endophenotypes;Age-related disease endophenotypes; BRCA cis rs16854884 0.657 rs62269895 chr3:143749085 C/G cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.52e-18 Economic and political preferences (feminism/equality); BRCA trans rs2204008 0.575 rs10444564 chr12:38043782 T/C cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.55e-21 Bladder cancer; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg13047869 chr3:10149882 C3orf24 -0.55 -10.19 -0.37 1.04e-22 Alzheimer's disease; BRCA cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.56 -10.48 -0.38 7.86e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg02544614 chr20:61657117 NA 0.28 7.82 0.3 2.14e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs17270561 0.609 rs9358878 chr6:25740273 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.84 0.33 8.92e-18 Iron status biomarkers; BRCA cis rs7267979 0.932 rs424487 chr20:25468131 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.81 0.33 1.18e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6005807 0.719 rs9625512 chr22:29020756 G/C cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs6723226 0.750 rs762019 chr2:32688601 A/C cg02381751 chr2:32503542 YIPF4 0.48 10.23 0.38 7.52e-23 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg15352829 chr14:105391018 PLD4 -0.41 -13.03 -0.46 1.44e-34 Rheumatoid arthritis; BRCA cis rs4889855 0.505 rs7501740 chr17:78610345 A/G cg16591659 chr17:78472290 NA -0.31 -8.0 -0.3 6.06e-15 Fractional excretion of uric acid; BRCA cis rs12310956 0.515 rs1852221 chr12:33945489 G/T cg06521331 chr12:34319734 NA -0.55 -10.7 -0.39 1.04e-24 Morning vs. evening chronotype; BRCA cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg21918786 chr6:109611834 NA -0.48 -13.79 -0.48 4.72e-38 Reticulocyte fraction of red cells; BRCA cis rs17253792 0.908 rs74354306 chr14:56065778 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.98 0.3 7e-15 Putamen volume; BRCA cis rs2836974 0.932 rs35571600 chr21:40590624 A/C cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.43e-64 Cognitive function; BRCA cis rs7267979 1.000 rs2387881 chr20:25378172 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.99 -0.34 2.81e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg11266682 chr4:10021025 SLC2A9 0.48 12.86 0.45 8.27e-34 Bone mineral density; BRCA cis rs9649465 1.000 rs56396297 chr7:123350535 T/C cg04330084 chr7:123175371 IQUB -0.3 -8.35 -0.31 4.35e-16 Migraine; BRCA cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg12386194 chr3:101231763 SENP7 0.46 9.77 0.36 4.14e-21 Colorectal cancer; BRCA cis rs4563143 0.675 rs55976444 chr19:29265214 G/C cg12667521 chr19:29218732 NA 0.47 8.66 0.32 3.79e-17 Methadone dose in opioid dependence; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg15112475 chr7:1198522 ZFAND2A -0.48 -10.82 -0.39 3.59e-25 Longevity;Endometriosis; BRCA cis rs477692 0.905 rs508360 chr10:131424969 A/G cg05714579 chr10:131428358 MGMT 0.59 14.69 0.5 2.65e-42 Response to temozolomide; BRCA cis rs651907 0.535 rs35799195 chr3:101521927 A/G cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.74e-21 Colorectal cancer; BRCA cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.43e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg25405998 chr7:65216604 CCT6P1 0.41 8.37 0.31 3.65e-16 Calcium levels; BRCA cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg27165867 chr14:105738592 BRF1 -0.36 -8.35 -0.31 4.09e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs875971 0.545 rs7787063 chr7:65628999 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.11 0.37 2.23e-22 Aortic root size; BRCA cis rs4285028 0.948 rs34158925 chr3:121678465 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg24846343 chr22:24311635 DDTL 0.56 14.85 0.51 4.73e-43 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2204008 0.614 rs4578492 chr12:38036350 T/C cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.62e-22 Bladder cancer; BRCA cis rs6580649 1.000 rs6580649 chr12:48410517 A/G cg05342945 chr12:48394962 COL2A1 -0.44 -8.42 -0.32 2.52e-16 Lung cancer; BRCA cis rs9837602 1.000 rs2291495 chr3:99782227 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.21 0.41 9.77e-27 Breast cancer; BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.82 0.62 1.71e-68 Platelet count; BRCA cis rs992157 0.835 rs12987219 chr2:219144149 G/A cg00012203 chr2:219082015 ARPC2 -0.48 -9.38 -0.35 1.17e-19 Colorectal cancer; BRCA cis rs332507 0.789 rs10755078 chr3:124378412 A/G cg05980111 chr3:124395277 KALRN 0.37 8.44 0.32 2.16e-16 Plateletcrit; BRCA cis rs1371614 0.589 rs502751 chr2:27111650 C/T cg12368169 chr2:27073192 DPYSL5 -0.3 -9.04 -0.34 1.89e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs13046373 0.507 rs11088139 chr21:31978884 T/G cg06468780 chr21:31798236 KRTAP13-3 0.36 9.0 0.34 2.61e-18 HDL cholesterol; BRCA cis rs10899021 1.000 rs11236190 chr11:74366755 G/T cg25880958 chr11:74394337 NA -0.69 -9.07 -0.34 1.42e-18 Response to metformin (IC50); BRCA cis rs9308433 0.529 rs3767842 chr1:214498306 C/T cg06198575 chr1:214491504 SMYD2 0.56 12.24 0.44 4.43e-31 IgG glycosylation; BRCA cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg11271282 chr2:238384023 NA 0.43 7.88 0.3 1.39e-14 Prostate cancer; BRCA cis rs2016266 0.819 rs10747662 chr12:53669821 A/T cg26875137 chr12:53738046 NA 0.38 9.52 0.35 3.59e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.8 17.42 0.57 6.31e-56 Smoking behavior; BRCA cis rs7267979 0.966 rs6050532 chr20:25308793 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.78 -0.36 3.81e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg05985134 chr18:33552581 C18orf21 0.67 12.75 0.45 2.36e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg11262906 chr1:85462892 MCOLN2 -0.52 -10.05 -0.37 3.7e-22 Serum sulfate level; BRCA cis rs11051970 0.879 rs2651363 chr12:32587550 G/T cg24626660 chr12:32551988 NA -0.29 -8.43 -0.32 2.27e-16 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs800082 0.668 rs9876975 chr3:144292255 G/A cg24215973 chr2:240111563 HDAC4 -0.43 -10.32 -0.38 3.26e-23 Smoking behavior; BRCA cis rs12618769 0.597 rs11888595 chr2:99084708 T/G cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg01475377 chr6:109611718 NA -0.59 -16.05 -0.54 5.8e-49 Reticulocyte fraction of red cells; BRCA trans rs3733585 0.673 rs116046986 chr4:9957794 A/G cg26043149 chr18:55253948 FECH -0.37 -8.28 -0.31 7.35e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg08807101 chr21:30365312 RNF160 -0.57 -14.01 -0.48 4.23e-39 Dental caries; BRCA cis rs6121246 0.559 rs6058462 chr20:30367674 C/T cg13852791 chr20:30311386 BCL2L1 0.84 18.2 0.58 6.18e-60 Mean corpuscular hemoglobin; BRCA cis rs10129255 0.500 rs8004923 chr14:107194164 A/G cg07958169 chr14:107095056 NA -0.38 -8.3 -0.31 6.17e-16 Kawasaki disease; BRCA cis rs7631605 0.905 rs11720064 chr3:37101519 G/T cg15934958 chr3:37212084 LRRFIP2 0.46 10.44 0.38 1.18e-23 Cerebrospinal P-tau181p levels; BRCA cis rs965469 0.947 rs6037578 chr20:3345911 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.54 -0.38 4.61e-24 IFN-related cytopenia; BRCA cis rs372883 0.507 rs8132992 chr21:30750561 T/C cg08807101 chr21:30365312 RNF160 0.36 8.11 0.31 2.69e-15 Pancreatic cancer; BRCA cis rs858239 0.670 rs3807452 chr7:23162081 C/T cg23682824 chr7:23144976 KLHL7 -0.39 -9.8 -0.36 3.09e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg21782813 chr7:2030301 MAD1L1 0.38 9.92 0.37 1.14e-21 Bipolar disorder and schizophrenia; BRCA cis rs72781680 1.000 rs7581107 chr2:24173565 C/T cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs561341 1.000 rs72823785 chr17:30273784 C/T cg23018236 chr17:30244563 NA -0.66 -10.6 -0.39 2.65e-24 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.953 rs75253516 chr8:58171547 C/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.06 -0.43 2.48e-30 Developmental language disorder (linguistic errors); BRCA cis rs4363385 0.818 rs12029168 chr1:152987993 G/A cg24667326 chr1:152973720 SPRR3 -0.31 -8.53 -0.32 1.09e-16 Inflammatory skin disease; BRCA cis rs9469578 0.901 rs57303110 chr6:33706159 G/A cg18708504 chr6:33715942 IP6K3 0.72 10.29 0.38 4.21e-23 Phosphorus levels; BRCA cis rs6815814 0.950 rs11727978 chr4:38811051 T/A cg06935464 chr4:38784597 TLR10 0.51 8.25 0.31 9.26e-16 Breast cancer; BRCA cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.59 0.5 8.24e-42 Motion sickness; BRCA cis rs1997103 0.954 rs6593222 chr7:55372932 A/C cg17469321 chr7:55412551 NA 0.49 9.21 0.34 4.66e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9467773 1.000 rs6926629 chr6:26499903 T/C cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.23e-60 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.579 rs2474575 chr10:38387901 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg26314531 chr2:26401878 FAM59B -0.63 -10.82 -0.39 3.74e-25 Gut microbiome composition (summer); BRCA cis rs775227 0.574 rs13068107 chr3:113029530 A/C cg18753928 chr3:113234510 CCDC52 -0.53 -9.17 -0.34 6.43e-19 Dental caries; BRCA cis rs2832077 0.506 rs2832088 chr21:30158620 G/A cg24692254 chr21:30365293 RNF160 -0.48 -10.24 -0.38 6.79e-23 Cognitive test performance; BRCA trans rs561341 1.000 rs113115092 chr17:30284164 G/A cg20587970 chr11:113659929 NA -1.2 -22.13 -0.66 5.45e-81 Hip circumference adjusted for BMI; BRCA cis rs9296092 0.538 rs75082458 chr6:33524792 C/T cg13560919 chr6:33536144 NA -0.85 -17.71 -0.57 2.21e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg24549020 chr5:56110836 MAP3K1 0.66 13.46 0.47 1.47e-36 Initial pursuit acceleration; BRCA cis rs208520 1.000 rs12190187 chr6:66973207 T/G cg07460842 chr6:66804631 NA 0.88 14.2 0.49 5.86e-40 Exhaled nitric oxide output; BRCA cis rs4727027 0.835 rs6959224 chr7:148784495 A/G cg23583168 chr7:148888333 NA -0.71 -15.78 -0.53 1.33e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10193935 0.892 rs6744964 chr2:42441088 A/G cg27598129 chr2:42591480 NA -0.92 -15.04 -0.51 5.67e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs6723226 0.721 rs3769600 chr2:32616879 G/A cg02381751 chr2:32503542 YIPF4 -0.48 -10.56 -0.39 3.89e-24 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.647 rs62026889 chr15:76917885 C/T cg23625390 chr15:77176239 SCAPER -0.55 -13.58 -0.47 4.26e-37 Blood metabolite levels; BRCA cis rs7666738 0.830 rs34212748 chr4:99068708 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg10150615 chr22:24372951 LOC391322 -0.46 -10.63 -0.39 2.06e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs236907 0.679 rs12750330 chr1:171803556 G/A cg13482142 chr2:234261155 NA 0.51 8.06 0.3 3.67e-15 Mean platelet volume; BRCA cis rs6714710 0.603 rs78006955 chr2:98455510 G/C cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.86e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg23719950 chr11:63933701 MACROD1 -0.53 -9.06 -0.34 1.56e-18 Mean platelet volume; BRCA cis rs1577917 0.958 rs11755864 chr6:86691791 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.73 -0.42 6.52e-29 Response to antipsychotic treatment; BRCA cis rs2404602 0.735 rs283789 chr15:76777577 G/A cg23625390 chr15:77176239 SCAPER 0.51 12.74 0.45 2.75e-33 Blood metabolite levels; BRCA cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 13.55 0.47 5.79e-37 Colorectal cancer; BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.59 -0.39 3.03e-24 Gut microbiome composition (summer); BRCA cis rs3767633 0.925 rs4579731 chr1:161766859 G/A cg09175582 chr1:161736000 ATF6 0.49 8.08 0.3 3.16e-15 IgG glycosylation; BRCA cis rs9837602 0.592 rs1711557 chr3:99425669 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.47 -8.96 -0.33 3.45e-18 Breast cancer; BRCA cis rs9640161 0.702 rs11765692 chr7:150026567 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.55 -13.95 -0.48 8.1e-39 Blood protein levels;Circulating chemerin levels; BRCA cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.05 0.4 4.42e-26 Bipolar disorder; BRCA cis rs2066819 1.000 rs58852079 chr12:56706922 A/C cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg12193833 chr17:30244370 NA -0.55 -8.65 -0.32 4.25e-17 Hip circumference adjusted for BMI; BRCA trans rs877282 0.842 rs7092986 chr10:756373 G/A cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 16.95 0.56 1.64e-53 Platelet count; BRCA cis rs3772130 0.583 rs6767409 chr3:121564989 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.38 0.49 7.63e-41 Cognitive performance; BRCA cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg26248373 chr2:1572462 NA -0.62 -14.12 -0.49 1.37e-39 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9649465 0.967 rs9641717 chr7:123350060 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.29 -0.31 6.61e-16 Migraine; BRCA cis rs7552404 0.655 rs1146646 chr1:76265500 G/A cg22875332 chr1:76189707 ACADM 0.55 11.65 0.42 1.37e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10782582 0.593 rs6704444 chr1:76205108 T/C cg03433033 chr1:76189801 ACADM -0.49 -10.49 -0.38 7.15e-24 Daytime sleep phenotypes; BRCA cis rs6835098 0.923 rs7671278 chr4:174095769 A/G cg08422745 chr4:174089978 GALNT7 -0.77 -15.71 -0.53 2.9e-47 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1003719 0.680 rs7276569 chr21:38578207 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg13902645 chr11:5959945 NA -0.53 -11.03 -0.4 5.35e-26 DNA methylation (variation); BRCA cis rs9462027 0.628 rs9462010 chr6:34716605 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 7.83e-15 Systemic lupus erythematosus; BRCA cis rs4363385 0.818 rs11205166 chr1:152988627 C/G cg25856811 chr1:152973957 SPRR3 -0.31 -8.3 -0.31 6.32e-16 Inflammatory skin disease; BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -13.96 -0.48 7.58e-39 Platelet count; BRCA cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg20307385 chr11:47447363 PSMC3 -0.44 -9.09 -0.34 1.22e-18 Subjective well-being; BRCA cis rs6138458 0.626 rs6050259 chr20:25011423 A/G cg26195577 chr20:24973756 C20orf3 0.61 14.68 0.5 2.99e-42 Blood protein levels; BRCA cis rs2180341 0.960 rs7766942 chr6:127691323 G/T cg27446573 chr6:127587934 RNF146 0.86 19.7 0.61 7.62e-68 Breast cancer; BRCA cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg06238570 chr21:40685208 BRWD1 -0.4 -8.21 -0.31 1.27e-15 Menarche (age at onset); BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg03188948 chr7:1209495 NA 0.47 9.62 0.36 1.56e-20 Longevity;Endometriosis; BRCA cis rs7586879 0.789 rs13382979 chr2:25131736 G/A cg01884057 chr2:25150051 NA 0.31 7.89 0.3 1.32e-14 Body mass index; BRCA cis rs919433 0.783 rs55725278 chr2:198238223 C/T cg00792783 chr2:198669748 PLCL1 0.35 7.83 0.3 1.98e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9368481 0.645 rs10456350 chr6:26975581 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.42 0.32 2.44e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs7582180 0.764 rs12999779 chr2:100924321 T/G cg14675211 chr2:100938903 LONRF2 0.48 11.13 0.4 2.09e-26 Intelligence (multi-trait analysis); BRCA cis rs7584330 0.744 rs72620822 chr2:238379582 C/T cg14458575 chr2:238380390 NA 0.78 17.5 0.57 2.69e-56 Prostate cancer; BRCA cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg08859206 chr1:53392774 SCP2 0.48 10.78 0.39 5.03e-25 Monocyte count; BRCA cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg22467129 chr15:76604101 ETFA -0.46 -10.24 -0.38 7.17e-23 Blood metabolite levels; BRCA trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg25214090 chr10:38739885 LOC399744 0.57 12.97 0.46 2.47e-34 Corneal astigmatism; BRCA cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg08999081 chr20:33150536 PIGU 0.37 9.44 0.35 6.93e-20 Coronary artery disease; BRCA trans rs3780486 0.505 rs10813959 chr9:33166234 C/T cg04842962 chr6:43655489 MRPS18A -0.83 -21.01 -0.64 6.46e-75 IgG glycosylation; BRCA cis rs6005807 0.719 rs9625524 chr22:29052951 C/T cg12565055 chr22:29076175 TTC28 0.48 9.46 0.35 6.01e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs9325144 0.555 rs61929925 chr12:38698828 C/A cg26384229 chr12:38710491 ALG10B -0.57 -13.92 -0.48 1.21e-38 Morning vs. evening chronotype; BRCA cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11644478 chr21:40555479 PSMG1 -0.54 -11.63 -0.42 1.73e-28 Menarche (age at onset); BRCA cis rs2836974 0.867 rs77959119 chr21:40542768 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.76 0.6 6.99e-63 Cognitive function; BRCA cis rs6835098 0.962 rs3733477 chr4:174090004 G/A cg08422745 chr4:174089978 GALNT7 -0.81 -17.84 -0.58 4.44e-58 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7904368 0.806 rs3858182 chr10:16855094 C/T cg23933602 chr10:16859644 RSU1 0.56 9.02 0.34 2.13e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7607369 0.759 rs10179708 chr2:219390967 T/A cg10223061 chr2:219282414 VIL1 0.3 8.78 0.33 1.52e-17 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs16854884 0.657 rs35085196 chr3:143712210 C/T cg06585982 chr3:143692056 C3orf58 0.44 9.03 0.34 2.09e-18 Economic and political preferences (feminism/equality); BRCA cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg22800045 chr5:56110881 MAP3K1 -0.46 -9.1 -0.34 1.17e-18 Initial pursuit acceleration; BRCA cis rs11098499 0.909 rs10002083 chr4:120311152 C/T cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs10752881 1.000 rs8179283 chr1:182974602 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.71 0.55 2.93e-52 Colorectal cancer; BRCA cis rs2652822 0.525 rs17828874 chr15:63516266 C/G cg02713581 chr15:63449717 RPS27L -0.42 -8.3 -0.31 6.02e-16 Metabolic traits; BRCA trans rs61931739 0.892 rs73309466 chr12:34093146 A/G cg26384229 chr12:38710491 ALG10B -0.4 -8.94 -0.33 4.03e-18 Morning vs. evening chronotype; BRCA cis rs2835872 0.758 rs8134288 chr21:39036989 T/C cg06728970 chr21:39037746 KCNJ6 0.45 12.93 0.46 3.95e-34 Electroencephalographic traits in alcoholism; BRCA cis rs7647973 1.000 rs7644148 chr3:49545241 G/A cg07636037 chr3:49044803 WDR6 -0.74 -16.07 -0.54 4.89e-49 Menarche (age at onset); BRCA cis rs7944584 0.632 rs749067 chr11:47318157 T/C cg03711944 chr11:47377212 SPI1 -0.35 -7.98 -0.3 6.58e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg07537917 chr2:241836409 C2orf54 -0.48 -11.38 -0.41 1.94e-27 Urinary metabolites; BRCA cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg04756594 chr16:24857601 SLC5A11 0.34 8.51 0.32 1.21e-16 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.62 -0.55 7.91e-52 Alzheimer's disease (late onset); BRCA cis rs12142240 0.660 rs72886903 chr1:46813860 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs1059312 0.808 rs10847694 chr12:129292457 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.78 -19.6 -0.61 2.49e-67 Systemic lupus erythematosus; BRCA cis rs7937890 0.967 rs963212 chr11:14324732 A/G cg22961513 chr11:14280813 SPON1 0.3 7.83 0.3 2.08e-14 Mitochondrial DNA levels; BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg00149659 chr3:10157352 C3orf10 0.71 12.33 0.44 1.69e-31 Alzheimer's disease; BRCA cis rs858239 0.601 rs4140959 chr7:23170776 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.9 0.43 1.19e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs490234 0.702 rs4838275 chr9:128352785 C/T cg14078157 chr9:128172775 NA -0.52 -11.44 -0.41 1.08e-27 Mean arterial pressure; BRCA cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg05234568 chr11:5960015 NA -0.43 -8.64 -0.32 4.6e-17 DNA methylation (variation); BRCA cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12826209 chr6:26865740 GUSBL1 -0.55 -9.86 -0.36 1.86e-21 Intelligence (multi-trait analysis); BRCA cis rs1029738 0.659 rs1608553 chr7:22896231 G/C cg15401507 chr7:22894281 NA -0.41 -9.38 -0.35 1.15e-19 Fibrinogen levels; BRCA cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg19482086 chr6:160211437 TCP1;MRPL18 0.69 17.76 0.57 1.21e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs10992471 0.603 rs10992342 chr9:95212068 C/T cg14631576 chr9:95140430 CENPP -0.38 -9.38 -0.35 1.18e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7107174 0.901 rs10899496 chr11:78123831 A/G cg27205649 chr11:78285834 NARS2 -0.29 -8.51 -0.32 1.23e-16 Testicular germ cell tumor; BRCA cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg01448562 chr3:133502909 NA -0.63 -14.87 -0.51 3.7e-43 Iron status biomarkers; BRCA cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg06784218 chr1:46089804 CCDC17 -0.53 -12.89 -0.45 5.96e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1023500 0.505 rs134887 chr22:42674239 A/G cg04733989 chr22:42467013 NAGA 0.37 8.2 0.31 1.32e-15 Schizophrenia; BRCA cis rs4780401 0.609 rs11639945 chr16:11824056 T/G cg01061890 chr16:11836724 TXNDC11 -0.55 -12.8 -0.45 1.54e-33 Rheumatoid arthritis; BRCA cis rs1865721 1.000 rs72977890 chr18:73198776 C/A cg26385618 chr18:73139727 C18orf62 -0.38 -8.56 -0.32 8.24e-17 Intelligence; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg21143896 chr7:2802374 GNA12 -0.36 -8.68 -0.32 3.25e-17 Height; BRCA trans rs783540 0.967 rs1269134 chr15:83282628 T/C cg18393722 chr15:85113863 UBE2QP1 -0.29 -8.9 -0.33 5.59e-18 Schizophrenia; BRCA cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.5e-34 Asthma (sex interaction); BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg11814155 chr7:99998594 ZCWPW1 0.54 8.93 0.33 4.49e-18 Platelet count; BRCA cis rs6598955 0.671 rs12085416 chr1:26627835 T/C cg04990556 chr1:26633338 UBXN11 0.55 9.24 0.34 3.56e-19 Obesity-related traits; BRCA cis rs2637030 0.515 rs2130744 chr5:52896723 C/T cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg03354898 chr7:1950403 MAD1L1 -0.39 -8.17 -0.31 1.69e-15 Bipolar disorder and schizophrenia; BRCA cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg25427524 chr10:38739819 LOC399744 -0.66 -16.17 -0.54 1.56e-49 Extrinsic epigenetic age acceleration; BRCA cis rs11971779 0.625 rs10260850 chr7:139003602 G/T cg07862535 chr7:139043722 LUC7L2 0.31 8.19 0.31 1.46e-15 Diisocyanate-induced asthma; BRCA cis rs12458462 0.892 rs58675823 chr18:77463672 G/A cg11879182 chr18:77439856 CTDP1 0.63 13.39 0.47 3.34e-36 Monocyte count; BRCA cis rs13108904 0.875 rs1564509 chr4:1236562 C/G cg00684032 chr4:1343700 KIAA1530 0.31 7.84 0.3 1.89e-14 Obesity-related traits; BRCA cis rs11809207 0.574 rs2783630 chr1:26504741 G/A cg23602478 chr1:26503979 CNKSR1 0.23 8.01 0.3 5.44e-15 Height; BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.93 0.37 1.03e-21 Gut microbiome composition (summer); BRCA cis rs1577917 0.958 rs12190603 chr6:86475718 C/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -8.07 -0.3 3.49e-15 Response to antipsychotic treatment; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.29 9.85 0.36 2.15e-21 Bipolar disorder; BRCA cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.95 -0.37 8.79e-22 Alzheimer's disease (late onset); BRCA cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg01884057 chr2:25150051 NA 0.34 9.22 0.34 4.2e-19 Body mass index; BRCA cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg21724239 chr8:58056113 NA 0.58 9.46 0.35 6.03e-20 Developmental language disorder (linguistic errors); BRCA cis rs7560272 0.538 rs4852972 chr2:73916672 C/T cg20560298 chr2:73613845 ALMS1 0.36 9.26 0.34 3.06e-19 Schizophrenia; BRCA cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg24692254 chr21:30365293 RNF160 -0.63 -16.57 -0.55 1.49e-51 Dental caries; BRCA cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg03354898 chr7:1950403 MAD1L1 -0.43 -8.52 -0.32 1.19e-16 Bipolar disorder and schizophrenia; BRCA cis rs16958440 0.867 rs79712753 chr18:44676727 C/A cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs1580019 0.961 rs4460271 chr7:32496503 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.48 0.32 1.51e-16 Cognitive ability; BRCA cis rs55692411 0.537 rs35012435 chr3:50031840 C/T cg05623727 chr3:50126028 RBM5 0.45 8.59 0.32 6.59e-17 Intelligence (multi-trait analysis); BRCA cis rs2760061 0.626 rs591582 chr1:228117360 C/A cg02753203 chr1:228287806 NA -0.6 -12.84 -0.45 1.01e-33 Diastolic blood pressure; BRCA trans rs4650994 0.525 rs2493848 chr1:178547838 T/A cg05059571 chr16:84539110 KIAA1609 0.54 12.45 0.44 5.11e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -9.03 -0.34 1.93e-18 Alzheimer's disease (late onset); BRCA cis rs1568889 1.000 rs7951681 chr11:28273894 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.65 14.13 0.49 1.18e-39 Bipolar disorder; BRCA cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 10.97 0.4 8.87e-26 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.79 -19.86 -0.62 1e-68 Systemic lupus erythematosus; BRCA cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg13010199 chr12:38710504 ALG10B 0.36 8.42 0.32 2.47e-16 Morning vs. evening chronotype; BRCA cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg16339924 chr4:17578868 LAP3 0.64 15.76 0.53 1.69e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9814567 0.964 rs10935113 chr3:134173091 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.57 -17.14 -0.56 1.9e-54 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4906332 0.966 rs12894275 chr14:103901424 A/G cg26031613 chr14:104095156 KLC1 0.45 8.17 0.31 1.63e-15 Coronary artery disease; BRCA cis rs2404602 0.647 rs12905181 chr15:77098431 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.88 -0.48 1.77e-38 Blood metabolite levels; BRCA cis rs8180040 0.654 rs6773521 chr3:47234419 A/G cg16586182 chr3:47516702 SCAP 0.56 12.61 0.45 1.06e-32 Colorectal cancer; BRCA cis rs763121 0.853 rs6001214 chr22:39149155 C/T cg06544989 chr22:39130855 UNC84B 0.38 8.6 0.32 6.13e-17 Menopause (age at onset); BRCA cis rs11690935 0.632 rs6737308 chr2:172872042 G/A cg13550731 chr2:172543902 DYNC1I2 0.52 12.68 0.45 5.09e-33 Schizophrenia; BRCA cis rs9768139 0.733 rs12698208 chr7:158117575 C/T cg24154853 chr7:158122151 PTPRN2 0.35 8.44 0.32 2.1e-16 Calcium levels; BRCA cis rs634534 0.561 rs655744 chr11:65776585 G/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.6 -13.39 -0.47 3.21e-36 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs801193 1.000 rs2659889 chr7:66217112 A/G cg11764359 chr7:65958608 NA 0.68 15.01 0.51 7.32e-44 Aortic root size; BRCA cis rs9457247 0.765 rs9457249 chr6:167426438 A/G cg07741184 chr6:167504864 NA 0.29 8.37 0.31 3.57e-16 Crohn's disease; BRCA cis rs7917772 0.560 rs11595170 chr10:104339851 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.82 -0.48 3.56e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs783540 1.000 rs783540 chr15:83254708 C/T cg18393722 chr15:85113863 UBE2QP1 0.26 8.24 0.31 9.98e-16 Schizophrenia; BRCA cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg22117172 chr7:91764530 CYP51A1 0.23 7.84 0.3 1.88e-14 Breast cancer; BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.72 -0.33 2.36e-17 Total body bone mineral density; BRCA trans rs11098499 0.954 rs4345162 chr4:120312959 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 13.92 0.48 1.14e-38 Hip circumference adjusted for BMI; BRCA cis rs67981189 0.634 rs221900 chr14:71604354 C/T cg15816911 chr14:71606274 NA 0.42 9.08 0.34 1.32e-18 Schizophrenia; BRCA cis rs9649465 0.935 rs3807636 chr7:123368488 G/A cg04330084 chr7:123175371 IQUB -0.33 -8.98 -0.33 2.93e-18 Migraine; BRCA cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B 0.4 8.87 0.33 7.46e-18 IgG glycosylation; BRCA cis rs7666738 0.830 rs17027090 chr4:98897923 G/T cg05340658 chr4:99064831 C4orf37 0.62 14.93 0.51 1.92e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.955 rs6815725 chr4:120158410 C/A cg09307838 chr4:120376055 NA 0.61 12.23 0.44 4.63e-31 Corneal astigmatism; BRCA cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg23649088 chr2:200775458 C2orf69 0.62 10.73 0.39 8.46e-25 Schizophrenia; BRCA cis rs1371614 0.655 rs4665927 chr2:27149366 A/T cg00617064 chr2:27272375 NA 0.31 8.19 0.31 1.48e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs13108904 0.539 rs13141169 chr4:1340353 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -8.06 -0.3 3.7e-15 Obesity-related traits; BRCA cis rs17376456 0.825 rs34592268 chr5:93232751 G/C cg25358565 chr5:93447407 FAM172A 1.17 18.51 0.59 1.52e-61 Diabetic retinopathy; BRCA cis rs875971 0.545 rs2420456 chr7:65745606 T/G cg11764359 chr7:65958608 NA 0.66 11.88 0.43 1.43e-29 Aortic root size; BRCA cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg02466173 chr16:30829666 NA -0.42 -9.36 -0.35 1.39e-19 Dementia with Lewy bodies; BRCA trans rs4819388 0.915 rs7278940 chr21:45648992 C/T cg17383793 chr5:52405638 MOCS2 -0.48 -11.03 -0.4 5e-26 Celiac disease; BRCA cis rs8058578 0.832 rs35969813 chr16:30714417 T/C cg00531865 chr16:30841666 NA -0.51 -11.42 -0.41 1.33e-27 Multiple myeloma; BRCA cis rs8031584 0.541 rs2955777 chr15:31219788 A/C cg14829155 chr15:31115871 NA 0.41 9.94 0.37 9.24e-22 Huntington's disease progression; BRCA cis rs7264396 0.635 rs6058378 chr20:34546658 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.4 8.4 0.32 2.87e-16 Total cholesterol levels; BRCA cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.71 11.89 0.43 1.38e-29 Mean platelet volume; BRCA cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg14993813 chr1:46806288 NSUN4 -0.45 -8.31 -0.31 5.63e-16 Menopause (age at onset); BRCA cis rs3806843 0.966 rs11741994 chr5:140145949 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.43 -10.01 -0.37 5.17e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs1577917 1.000 rs12200330 chr6:86656653 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.01 -0.3 5.55e-15 Response to antipsychotic treatment; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs7927771 0.524 rs12226431 chr11:47805856 G/A cg20307385 chr11:47447363 PSMC3 0.42 9.57 0.35 2.28e-20 Subjective well-being; BRCA cis rs2404602 0.735 rs2436996 chr15:76817420 C/T cg23625390 chr15:77176239 SCAPER -0.51 -12.15 -0.43 1.0500000000000001e-30 Blood metabolite levels; BRCA cis rs10267417 0.535 rs6960579 chr7:19869364 A/G cg05791153 chr7:19748676 TWISTNB 0.51 9.75 0.36 5.1e-21 Night sleep phenotypes; BRCA cis rs757110 0.705 rs10832778 chr11:17394073 C/G cg15432903 chr11:17409602 KCNJ11 0.71 15.59 0.52 1.15e-46 Type 2 diabetes; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs600806 0.778 rs12145677 chr1:110023610 G/A cg20591472 chr1:110008990 SYPL2 -0.32 -8.21 -0.31 1.2e-15 Intelligence (multi-trait analysis); BRCA cis rs7914558 1.000 rs7899084 chr10:104872547 A/T cg04362960 chr10:104952993 NT5C2 0.44 10.81 0.39 4.09e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs11252926 0.661 rs7077209 chr10:484159 A/G cg18196295 chr10:418757 DIP2C -0.47 -11.08 -0.4 3.17e-26 Psychosis in Alzheimer's disease; BRCA cis rs6460942 1.000 rs7808819 chr7:12297440 C/T cg06484146 chr7:12443880 VWDE -0.65 -8.92 -0.33 5.04e-18 Coronary artery disease; BRCA cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg24642439 chr20:33292090 TP53INP2 0.71 16.46 0.55 5.15e-51 Coronary artery disease; BRCA cis rs2576037 0.901 rs6507719 chr18:44581310 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.39 7.94 0.3 9.23e-15 Personality dimensions; BRCA cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.33 -10.72 -0.39 9.2e-25 Autism spectrum disorder or schizophrenia; BRCA cis rs57221529 0.766 rs56216231 chr5:581193 G/A cg09021430 chr5:549028 NA -0.69 -14.55 -0.5 1.3e-41 Lung disease severity in cystic fibrosis; BRCA cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg00012203 chr2:219082015 ARPC2 -0.41 -8.04 -0.3 4.32e-15 Ulcerative colitis; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg20007245 chr22:24372913 LOC391322 -0.55 -12.18 -0.43 7.42e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9311474 0.713 rs352169 chr3:52236762 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.87 -0.3 1.53e-14 Electroencephalogram traits; BRCA cis rs66887589 0.967 rs2892869 chr4:120521297 T/C cg09307838 chr4:120376055 NA -0.44 -9.16 -0.34 7.02e-19 Diastolic blood pressure; BRCA cis rs7772486 0.686 rs9376956 chr6:145949844 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.21 0.56 7.67e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg18538332 chr22:24372958 LOC391322 0.58 14.6 0.5 7.36e-42 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17685 0.753 rs869806 chr7:75688623 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.72 -0.33 2.34e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg04455712 chr21:45112962 RRP1B 0.38 9.76 0.36 4.61e-21 Mean corpuscular volume; BRCA cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.6 12.14 0.43 1.11e-30 Lymphocyte counts; BRCA cis rs2422052 0.505 rs7569755 chr2:118648261 G/A cg22545206 chr2:118617499 NA -0.37 -7.96 -0.3 7.96e-15 Mosquito bite size; BRCA cis rs17685 0.625 rs1639630 chr7:75730499 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.57 -0.32 7.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10754283 0.967 rs7552896 chr1:90103194 A/G cg21401794 chr1:90099060 LRRC8C 0.49 11.63 0.42 1.79e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg14926445 chr8:58193284 C8orf71 -0.46 -8.88 -0.33 6.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs9814567 0.964 rs4539979 chr3:134287597 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.43 -0.61 1.94e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.21 -0.56 7.85e-55 Blood protein levels; BRCA cis rs6952808 0.692 rs59619245 chr7:2068630 C/T cg00106254 chr7:1943704 MAD1L1 -0.43 -10.79 -0.39 4.91e-25 Bipolar disorder and schizophrenia; BRCA cis rs7631605 0.935 rs9831084 chr3:37025661 T/C cg15934958 chr3:37212084 LRRFIP2 0.4 9.17 0.34 6.33e-19 Cerebrospinal P-tau181p levels; BRCA cis rs1577917 0.917 rs4707226 chr6:86527828 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.48 -0.41 7.11e-28 Response to antipsychotic treatment; BRCA cis rs7264396 0.561 rs2050930 chr20:34579397 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.51 -9.46 -0.35 6.02e-20 Total cholesterol levels; BRCA cis rs2243480 1.000 rs2707844 chr7:66059509 G/A cg18252515 chr7:66147081 NA -1.04 -15.52 -0.52 2.55e-46 Diabetic kidney disease; BRCA cis rs10992471 0.756 rs7043152 chr9:95138499 A/G cg14631576 chr9:95140430 CENPP -0.37 -8.97 -0.33 3.26e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7651736 1.000 rs7651736 chr3:136760598 A/G cg21827317 chr3:136751795 NA 0.45 9.84 0.36 2.22e-21 Neuroticism; BRCA cis rs7267979 0.966 rs6037103 chr20:25369095 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.12 -0.34 9.31e-19 Liver enzyme levels (alkaline phosphatase); BRCA trans rs4332037 0.510 rs11764040 chr7:1884830 G/C cg11693508 chr17:37793320 STARD3 0.48 10.42 0.38 1.35e-23 Bipolar disorder; BRCA cis rs7772486 0.754 rs1055212 chr6:146058315 A/T cg13319975 chr6:146136371 FBXO30 0.43 9.87 0.36 1.78e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg13319975 chr6:146136371 FBXO30 0.61 13.76 0.48 6.68e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.99 0.34 2.73e-18 Motion sickness; BRCA cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg21770322 chr7:97807741 LMTK2 0.45 11.78 0.42 3.98e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs9487051 0.734 rs56214745 chr6:109536748 G/T cg01475377 chr6:109611718 NA -0.43 -10.77 -0.39 5.94e-25 Reticulocyte fraction of red cells; BRCA cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg04972856 chr6:88032051 C6orf162;GJB7 0.3 7.99 0.3 6.38e-15 Monocyte percentage of white cells; BRCA cis rs1707322 0.752 rs61784793 chr1:46149285 G/A cg06784218 chr1:46089804 CCDC17 0.5 12.0 0.43 4.75e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg22535103 chr8:58192502 C8orf71 -0.43 -8.72 -0.33 2.42e-17 Developmental language disorder (linguistic errors); BRCA cis rs6840360 0.533 rs4696295 chr4:152717430 T/C cg22705602 chr4:152727874 NA 0.39 10.43 0.38 1.24e-23 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg22920501 chr2:26401640 FAM59B 0.9 16.26 0.54 5.15e-50 Gut microbiome composition (summer); BRCA cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg13902645 chr11:5959945 NA -0.55 -11.61 -0.42 2.06e-28 DNA methylation (variation); BRCA cis rs6763687 0.892 rs4894798 chr3:171795514 T/C cg16233210 chr3:171778391 FNDC3B 0.42 9.77 0.36 4.13e-21 Red cell distribution width; BRCA cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg16405210 chr4:1374714 KIAA1530 -0.54 -12.83 -0.45 1.05e-33 Longevity; BRCA cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg11644478 chr21:40555479 PSMG1 0.53 11.55 0.42 3.65e-28 Cognitive function; BRCA trans rs1459104 1.000 rs66510003 chr11:55160196 G/A cg15704280 chr7:45808275 SEPT13 0.63 8.0 0.3 5.74e-15 Body mass index; BRCA cis rs2901460 0.509 rs12465313 chr2:62078301 G/A cg02183531 chr2:62113199 CCT4 -0.47 -9.27 -0.34 2.72e-19 Mean corpuscular volume; BRCA cis rs6138458 1.000 rs6114980 chr20:24974288 A/G cg26195577 chr20:24973756 C20orf3 1.03 28.97 0.75 1.65e-118 Blood protein levels; BRCA cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg05025164 chr4:1340916 KIAA1530 0.37 8.13 0.31 2.24e-15 Longevity; BRCA cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg06212747 chr3:49208901 KLHDC8B 0.46 9.34 0.35 1.53e-19 Parkinson's disease; BRCA cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg21782813 chr7:2030301 MAD1L1 0.3 7.94 0.3 8.89e-15 Bipolar disorder and schizophrenia; BRCA cis rs7246657 0.943 rs7252325 chr19:37930645 A/G cg18154014 chr19:37997991 ZNF793 0.5 9.78 0.36 3.69e-21 Coronary artery calcification; BRCA cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg18964960 chr10:1102726 WDR37 -0.47 -9.01 -0.34 2.46e-18 Response to angiotensin II receptor blocker therapy; BRCA cis rs7851660 0.967 rs13288000 chr9:100608980 A/G cg13688889 chr9:100608707 NA -0.37 -8.88 -0.33 6.84e-18 Strep throat; BRCA cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 14.33 0.49 1.3e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13118159 0.836 rs2276903 chr4:1343405 A/G cg20887711 chr4:1340912 KIAA1530 0.42 10.21 0.37 9.14e-23 Longevity; BRCA cis rs9640161 0.789 rs1464751 chr7:150021282 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.56 -13.85 -0.48 2.58e-38 Blood protein levels;Circulating chemerin levels; BRCA cis rs6545883 0.868 rs7608483 chr2:61836235 A/C cg15711740 chr2:61764176 XPO1 -0.55 -13.86 -0.48 2.21e-38 Tuberculosis; BRCA cis rs9487051 0.702 rs670414 chr6:109529912 A/G cg01475377 chr6:109611718 NA 0.43 10.44 0.38 1.17e-23 Reticulocyte fraction of red cells; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg25036284 chr2:26402008 FAM59B 0.95 15.98 0.53 1.27e-48 Gut microbiome composition (summer); BRCA cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.59 -0.32 6.45e-17 Glomerular filtration rate (creatinine); BRCA trans rs7980799 0.682 rs61927702 chr12:33631695 A/G cg26384229 chr12:38710491 ALG10B -0.48 -10.34 -0.38 2.75e-23 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6570726 0.818 rs412350 chr6:145852409 T/C cg23711669 chr6:146136114 FBXO30 0.79 18.81 0.6 3.79e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs9682041 0.696 rs6786542 chr3:170105378 C/T cg11886554 chr3:170076028 SKIL 0.51 10.05 0.37 3.75e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs8023845 1.000 rs62019997 chr15:40443476 T/C cg20259534 chr15:40453036 BUB1B 0.58 8.47 0.32 1.72e-16 Chronic lymphocytic leukemia; BRCA cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg17420585 chr12:42539391 GXYLT1 -0.6 -14.89 -0.51 2.85e-43 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs9768139 0.733 rs13221388 chr7:158119270 G/A cg24154853 chr7:158122151 PTPRN2 0.35 8.16 0.31 1.73e-15 Calcium levels; BRCA cis rs524281 0.692 rs2302884 chr11:65824084 C/T cg16950941 chr11:66035639 RAB1B -0.41 -8.94 -0.33 4.28e-18 Electroencephalogram traits; BRCA cis rs2625529 0.652 rs2899775 chr15:72268354 C/T cg16672083 chr15:72433130 SENP8 0.68 16.32 0.54 2.58e-50 Red blood cell count; BRCA trans rs2562456 0.761 rs35008138 chr19:21731624 A/T cg25042112 chr7:64838748 ZNF92 -0.45 -8.34 -0.31 4.45e-16 Pain; BRCA cis rs11105298 0.891 rs11105299 chr12:89877943 A/G cg00757033 chr12:89920650 WDR51B 0.52 10.44 0.38 1.13e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7394190 0.748 rs78790589 chr10:75539598 G/A cg07699608 chr10:75541558 CHCHD1 0.71 10.37 0.38 2.13e-23 Incident atrial fibrillation; BRCA cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.83 0.39 3.42e-25 Bipolar disorder; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg18301423 chr5:131593218 PDLIM4 0.31 7.96 0.3 7.71e-15 Breast cancer; BRCA cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.17e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs13082711 0.911 rs11719386 chr3:27505636 G/C cg02860705 chr3:27208620 NA 0.59 11.06 0.4 3.95e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg03351412 chr1:154909251 PMVK 0.61 14.04 0.49 3.04e-39 Prostate cancer; BRCA cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.71 0.33 2.65e-17 Tonsillectomy; BRCA cis rs11098499 0.954 rs6849171 chr4:120409549 G/A cg09307838 chr4:120376055 NA 0.76 16.93 0.56 2.2e-53 Corneal astigmatism; BRCA cis rs4889609 0.834 rs72785520 chr16:31070778 C/T cg02466173 chr16:30829666 NA -0.43 -9.67 -0.36 9.42e-21 Response to metformin (IC50); BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18758796 chr5:131593413 PDLIM4 0.34 8.85 0.33 8.33e-18 Breast cancer; BRCA cis rs6665290 0.558 rs1319103 chr1:227219314 A/G cg10327440 chr1:227177885 CDC42BPA -0.74 -16.81 -0.55 8.96e-53 Myeloid white cell count; BRCA cis rs9487051 0.743 rs388526 chr6:109543425 C/G cg21918786 chr6:109611834 NA -0.35 -8.61 -0.32 5.78e-17 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs453301 0.658 rs6983877 chr8:8904639 T/C cg06636001 chr8:8085503 FLJ10661 -0.47 -9.97 -0.37 7.2e-22 Joint mobility (Beighton score); BRCA cis rs61931739 0.500 rs11053193 chr12:34438838 G/T cg06521331 chr12:34319734 NA -0.56 -10.12 -0.37 2.01e-22 Morning vs. evening chronotype; BRCA cis rs11764590 0.694 rs7797112 chr7:2085165 T/C cg23422044 chr7:1970798 MAD1L1 -0.45 -9.44 -0.35 6.86e-20 Neuroticism; BRCA cis rs9814567 1.000 rs2370641 chr3:134222161 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11098499 0.954 rs66506550 chr4:120371445 T/A cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs7165102 1.000 rs8027260 chr15:65955172 A/C cg03382306 chr15:66097959 NA 0.36 9.79 0.36 3.6e-21 Mean corpuscular hemoglobin; BRCA cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg26408565 chr15:76604113 ETFA -0.38 -8.24 -0.31 1.01e-15 Blood metabolite levels; BRCA cis rs9487051 0.768 rs9480910 chr6:109521707 T/C cg01475377 chr6:109611718 NA -0.45 -11.4 -0.41 1.58e-27 Reticulocyte fraction of red cells; BRCA cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg11247378 chr22:39784982 NA -0.56 -12.98 -0.46 2.31e-34 Intelligence (multi-trait analysis); BRCA trans rs4714291 0.963 rs1743973 chr6:40094549 T/G cg02267698 chr19:7991119 CTXN1 0.41 7.95 0.3 8.35e-15 Strep throat; BRCA cis rs10499694 0.967 rs7786398 chr7:50612906 G/A cg18232548 chr7:50535776 DDC -0.35 -8.54 -0.32 9.48e-17 Body mass index; BRCA cis rs7103648 0.669 rs11039332 chr11:47695840 G/A cg03711944 chr11:47377212 SPI1 -0.38 -9.04 -0.34 1.88e-18 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.06 -0.3 3.88e-15 Menopause (age at onset); BRCA trans rs7980799 0.682 rs7311794 chr12:33635630 C/T cg26384229 chr12:38710491 ALG10B -0.47 -10.21 -0.37 8.62e-23 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs1915146 0.546 rs1715862 chr10:126856255 C/T cg23000734 chr10:126850823 CTBP2 -0.36 -9.14 -0.34 8.15e-19 Menarche (age at onset); BRCA cis rs2882667 0.505 rs6596465 chr5:138483026 A/G cg04439458 chr5:138467593 SIL1 0.31 8.46 0.32 1.8e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg16989086 chr20:62203971 PRIC285 0.53 8.97 0.33 3.29e-18 Glioma;Non-glioblastoma glioma;Glioblastoma; BRCA cis rs6546550 0.935 rs3214007 chr2:70098808 A/G cg02498382 chr2:70120550 SNRNP27 -0.5 -10.55 -0.39 4.3e-24 Prevalent atrial fibrillation; BRCA cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg26597838 chr10:835615 NA -0.43 -8.22 -0.31 1.18e-15 Response to angiotensin II receptor blocker therapy; BRCA cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg06115741 chr20:33292138 TP53INP2 -0.4 -8.8 -0.33 1.25e-17 Glomerular filtration rate (creatinine); BRCA cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg18357526 chr6:26021779 HIST1H4A -0.43 -7.94 -0.3 9.35e-15 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg20476274 chr7:133979776 SLC35B4 0.65 19.4 0.61 2.78e-66 Mean platelet volume; BRCA cis rs7809950 0.678 rs7803151 chr7:106934246 G/A cg23024343 chr7:107201750 COG5 -0.47 -9.27 -0.34 2.91e-19 Coronary artery disease; BRCA cis rs12477438 0.520 rs11689265 chr2:99799267 A/G cg08885076 chr2:99613938 TSGA10 0.44 10.4 0.38 1.62e-23 Chronic sinus infection; BRCA cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg05872129 chr22:39784769 NA -0.57 -13.12 -0.46 5.51e-35 Intelligence (multi-trait analysis); BRCA cis rs2991971 0.967 rs60608374 chr1:46008913 G/A cg24296786 chr1:45957014 TESK2 0.65 16.04 0.54 6.96e-49 High light scatter reticulocyte count; BRCA cis rs8058578 1.000 rs67128646 chr16:30672097 A/C cg00531865 chr16:30841666 NA -0.5 -11.11 -0.4 2.38e-26 Multiple myeloma; BRCA cis rs61931739 0.534 rs4931770 chr12:34044479 G/T cg06521331 chr12:34319734 NA -0.62 -11.16 -0.4 1.46e-26 Morning vs. evening chronotype; BRCA cis rs60871478 1.000 rs67721251 chr7:825114 T/C cg05535760 chr7:792225 HEATR2 0.72 13.22 0.46 1.9e-35 Cerebrospinal P-tau181p levels; BRCA cis rs208520 0.690 rs207094 chr6:66799009 G/A cg07460842 chr6:66804631 NA -1.0 -20.02 -0.62 1.44e-69 Exhaled nitric oxide output; BRCA trans rs28595532 0.557 rs4359977 chr4:119314055 T/C cg26518628 chr1:97050305 NA -0.61 -10.44 -0.38 1.18e-23 Cannabis dependence symptom count; BRCA cis rs1975991 0.711 rs6778034 chr3:187963710 A/G cg15417654 chr3:187959138 LPP 0.36 9.45 0.35 6.48e-20 White matter integrity (bipolar disorder risk interaction); BRCA cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg13770153 chr20:60521292 NA -0.42 -9.48 -0.35 5.05e-20 Body mass index; BRCA trans rs61931739 0.534 rs1384860 chr12:34045388 T/C cg26384229 chr12:38710491 ALG10B 0.56 12.16 0.43 9.7e-31 Morning vs. evening chronotype; BRCA cis rs501916 0.634 rs603569 chr15:48058929 G/A cg16110827 chr15:48056943 SEMA6D -0.41 -9.09 -0.34 1.21e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs453301 0.658 rs12114954 chr8:8904862 T/G cg15556689 chr8:8085844 FLJ10661 -0.36 -9.6 -0.36 1.73e-20 Joint mobility (Beighton score); BRCA cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg25019033 chr10:957182 NA -0.43 -8.89 -0.33 6.11e-18 Eosinophil percentage of granulocytes; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg00166722 chr3:10149974 C3orf24 0.62 11.1 0.4 2.62e-26 Alzheimer's disease; BRCA cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg18132916 chr6:79620363 NA -0.5 -11.86 -0.42 1.85e-29 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.905 rs7611367 chr3:161003182 A/G cg04691961 chr3:161091175 C3orf57 0.58 13.95 0.48 7.96e-39 Morning vs. evening chronotype; BRCA cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.36 -0.31 3.95e-16 Menarche (age at onset); BRCA trans rs2204008 0.550 rs11495600 chr12:38126654 C/T cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs5167 0.504 rs3760628 chr19:45457225 G/A cg09555818 chr19:45449301 APOC2 0.47 12.12 0.43 1.44e-30 Blood protein levels; BRCA cis rs6597981 0.604 rs7945912 chr11:750849 A/T cg21775979 chr11:780331 NA -0.36 -7.95 -0.3 8.62e-15 Breast cancer; BRCA cis rs208515 0.525 rs10944863 chr6:66676238 C/T cg07460842 chr6:66804631 NA 0.77 14.02 0.48 4.08e-39 Exhaled nitric oxide levels; BRCA cis rs67460515 0.500 rs6806015 chr3:160724766 G/A cg03342759 chr3:160939853 NMD3 -0.59 -11.86 -0.42 1.74e-29 Parkinson's disease; BRCA cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg24209194 chr3:40518798 ZNF619 -0.39 -7.91 -0.3 1.13e-14 Renal cell carcinoma; BRCA cis rs2070488 1.000 rs36006749 chr3:38443312 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.69 18.99 0.6 4.13e-64 Electrocardiographic conduction measures; BRCA cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg03433033 chr1:76189801 ACADM 0.76 17.54 0.57 1.62e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg15017067 chr4:17643749 FAM184B 0.26 7.87 0.3 1.53e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg02574844 chr11:5959923 NA -0.4 -7.84 -0.3 1.88e-14 DNA methylation (variation); BRCA trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -11.48 -0.41 7.07e-28 Neuroticism; BRCA cis rs8114671 0.836 rs6142284 chr20:33641367 G/A cg07148914 chr20:33460835 GGT7 -0.41 -8.96 -0.33 3.4e-18 Height; BRCA cis rs7975161 0.640 rs10735394 chr12:104687142 C/A cg25273343 chr12:104657179 TXNRD1 -0.5 -9.98 -0.37 7.05e-22 Toenail selenium levels; BRCA cis rs6740322 0.895 rs6710656 chr2:43566941 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.43 -0.44 6.17e-32 Coronary artery disease; BRCA trans rs9951602 0.512 rs4798995 chr18:76654344 T/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.3 0.59 1.73e-60 Obesity-related traits; BRCA cis rs2070488 1.000 rs34258593 chr3:38464565 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.51 0.63 3.48e-72 Electrocardiographic conduction measures; BRCA cis rs13223928 0.666 rs9986825 chr7:3151177 C/T cg19214707 chr7:3157722 NA 0.4 9.34 0.35 1.53e-19 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.954 rs17006190 chr4:120418838 C/G cg25214090 chr10:38739885 LOC399744 0.53 12.0 0.43 4.63e-30 Corneal astigmatism; BRCA cis rs9487051 0.768 rs9398188 chr6:109526615 G/A cg01475377 chr6:109611718 NA -0.41 -10.29 -0.38 4.49e-23 Reticulocyte fraction of red cells; BRCA cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg03146154 chr1:46216737 IPP -0.5 -11.07 -0.4 3.54e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.51 0.38 6.38e-24 Motion sickness; BRCA cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg03188948 chr7:1209495 NA 0.85 8.57 0.32 7.85e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs7582180 0.629 rs12991172 chr2:100941671 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA cis rs9942416 0.650 rs2640646 chr5:74977458 A/T cg19683494 chr5:74908142 NA -0.47 -8.72 -0.33 2.42e-17 Age-related disease endophenotypes; BRCA cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9291683 0.669 rs887733 chr4:10183108 T/C cg00071950 chr4:10020882 SLC2A9 -0.42 -9.51 -0.35 3.96e-20 Bone mineral density; BRCA cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg18225595 chr11:63971243 STIP1 0.51 9.38 0.35 1.11e-19 Mean platelet volume; BRCA cis rs11098499 0.874 rs12502503 chr4:120116255 C/T cg09307838 chr4:120376055 NA 0.6 11.16 0.4 1.57e-26 Corneal astigmatism; BRCA cis rs1065852 0.526 rs7290907 chr22:42390209 G/A cg22189786 chr22:42395067 WBP2NL 0.43 8.59 0.32 6.7e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs7666738 0.830 rs35644814 chr4:98886111 G/C cg05340658 chr4:99064831 C4orf37 0.62 14.93 0.51 1.86e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs7737355 0.898 rs3775998 chr5:130979332 A/G cg06307176 chr5:131281290 NA 0.52 10.28 0.38 4.63e-23 Life satisfaction; BRCA cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg00321850 chr1:175162397 KIAA0040 -0.41 -11.44 -0.41 1.08e-27 Alcohol dependence; BRCA cis rs2742540 0.503 rs2653556 chr11:8906636 C/G cg00186954 chr11:8933980 ST5;C11orf17 -0.32 -7.83 -0.3 1.99e-14 Hematocrit; BRCA cis rs2243480 1.000 rs56016656 chr7:65383481 C/T cg18252515 chr7:66147081 NA -0.9 -12.9 -0.45 5.33e-34 Diabetic kidney disease; BRCA cis rs12477438 0.520 rs2171359 chr2:99795360 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs7914558 1.000 rs8139 chr10:104848123 G/A cg04362960 chr10:104952993 NT5C2 0.43 10.25 0.38 6.27e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 8.41 0.32 2.74e-16 Axial length; BRCA cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 8.75 0.33 1.87e-17 Mean platelet volume; BRCA cis rs12893668 0.572 rs4906356 chr14:104138701 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.3 -0.38 4e-23 Reticulocyte count; BRCA cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg18876405 chr7:65276391 NA -0.54 -12.07 -0.43 2.41e-30 Calcium levels; BRCA cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg21770322 chr7:97807741 LMTK2 0.43 11.37 0.41 2.12e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg22907277 chr7:1156413 C7orf50 -0.48 -10.53 -0.38 4.9299999999999996e-24 Longevity;Endometriosis; BRCA cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg24060327 chr5:131705240 SLC22A5 -0.64 -12.48 -0.44 3.78e-32 Breast cancer; BRCA trans rs3780486 0.846 rs10124479 chr9:33136233 T/G cg04842962 chr6:43655489 MRPS18A 1.12 38.86 0.84 1.86e-170 IgG glycosylation; BRCA cis rs34779708 0.966 rs2045915 chr10:35418616 G/C cg03585969 chr10:35415529 CREM 0.44 9.13 0.34 8.93e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1997103 1.000 rs10278894 chr7:55404748 A/G cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.92e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg15145296 chr3:125709740 NA -0.57 -9.29 -0.34 2.42e-19 Blood pressure (smoking interaction); BRCA cis rs6450176 0.904 rs4351101 chr5:53300591 G/A ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.14 -0.51 1.8e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs1975991 0.538 rs9863680 chr3:187959089 C/G cg15417654 chr3:187959138 LPP -0.31 -8.1 -0.31 2.71e-15 White matter integrity (bipolar disorder risk interaction); BRCA cis rs12477438 0.798 rs6736064 chr2:99658201 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.96 -0.58 1.02e-58 Chronic sinus infection; BRCA cis rs41005 0.967 rs17433703 chr2:8115300 A/G cg03155496 chr2:8117019 LOC339788 0.61 17.68 0.57 2.99e-57 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs17685 0.753 rs4728586 chr7:75802869 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.41 -0.32 2.64e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1710278 0.967 rs1710288 chr10:127741286 C/G cg22975853 chr10:127789788 ADAM12 0.31 8.17 0.31 1.61e-15 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.76 0.36 4.41e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs7517560 chr1:46425943 A/G cg06784218 chr1:46089804 CCDC17 0.46 10.91 0.4 1.53e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1448094 0.512 rs7302741 chr12:86237127 C/T cg02569458 chr12:86230093 RASSF9 0.32 7.87 0.3 1.5e-14 Major depressive disorder; BRCA cis rs1577917 0.917 rs4098044 chr6:86462066 T/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.21 -0.31 1.19e-15 Response to antipsychotic treatment; BRCA cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -12.84 -0.45 1.03e-33 Chronic sinus infection; BRCA cis rs754466 0.958 rs11002341 chr10:79701363 A/C cg17075019 chr10:79541650 NA -0.64 -12.18 -0.43 7.71e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.2e-36 Developmental language disorder (linguistic errors); BRCA cis rs1865760 1.000 rs6905887 chr6:25912103 T/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.34 0.38 2.77e-23 Height; BRCA cis rs9649465 1.000 rs13230338 chr7:123373622 T/C cg04330084 chr7:123175371 IQUB -0.33 -9.0 -0.34 2.52e-18 Migraine; BRCA cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg04267008 chr7:1944627 MAD1L1 -0.57 -11.69 -0.42 9.51e-29 Bipolar disorder and schizophrenia; BRCA cis rs7714584 1.000 rs12656600 chr5:150311872 A/G cg22134413 chr5:150180641 NA 0.73 10.73 0.39 8.61e-25 Crohn's disease; BRCA cis rs2625529 0.556 rs55679065 chr15:72433395 C/T cg16672083 chr15:72433130 SENP8 0.68 16.91 0.56 2.89e-53 Red blood cell count; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg25036284 chr2:26402008 FAM59B 0.94 14.23 0.49 4.14e-40 Gut microbiome composition (summer); BRCA cis rs1865760 0.927 rs6915834 chr6:25935427 A/C cg16482183 chr6:26056742 HIST1H1C 0.51 10.41 0.38 1.45e-23 Height; BRCA cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.81 -0.36 2.89e-21 Developmental language disorder (linguistic errors); BRCA cis rs34779708 0.742 rs35912711 chr10:35312996 T/C cg03585969 chr10:35415529 CREM 0.49 10.25 0.38 6.46e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg00825309 chr19:58991885 ZNF446 -0.59 -12.82 -0.45 1.15e-33 Uric acid clearance; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg13628971 chr7:2884303 GNA12 0.44 9.28 0.34 2.62e-19 Height; BRCA cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg19077165 chr18:44547161 KATNAL2 0.37 7.98 0.3 7.04e-15 Personality dimensions; BRCA cis rs6546550 0.935 rs4853027 chr2:70039224 A/G cg02498382 chr2:70120550 SNRNP27 0.48 10.09 0.37 2.5e-22 Prevalent atrial fibrillation; BRCA cis rs7590720 0.959 rs2372684 chr2:216884764 C/A cg12620499 chr2:216877984 MREG 0.81 22.26 0.66 1.1e-81 Alcohol dependence; BRCA trans rs4689592 0.587 rs3822269 chr4:7069901 T/C cg07817883 chr1:32538562 TMEM39B -0.44 -8.3 -0.31 6.42e-16 Monocyte percentage of white cells; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg24642844 chr7:1081250 C7orf50 -0.88 -16.14 -0.54 2.03e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.84 0.42 2.3e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10746514 0.833 rs867844 chr1:232266278 A/T cg09506761 chr1:232265262 NA 0.42 8.8 0.33 1.32e-17 Response to statin therapy; BRCA cis rs10267417 0.535 rs6946403 chr7:19861549 C/T cg07541023 chr7:19748670 TWISTNB 0.49 8.97 0.33 3.22e-18 Night sleep phenotypes; BRCA cis rs6912958 0.781 rs9444504 chr6:88181046 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.5 -0.32 1.38e-16 Monocyte percentage of white cells; BRCA cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg06552810 chr11:31128660 NA 0.39 8.53 0.32 1.07e-16 Red blood cell count; BRCA trans rs11098499 0.955 rs7684942 chr4:120162201 C/T cg25214090 chr10:38739885 LOC399744 0.48 10.66 0.39 1.53e-24 Corneal astigmatism; BRCA cis rs10751667 0.857 rs7481221 chr11:966813 G/C ch.11.42038R chr11:967971 AP2A2 0.52 16.51 0.55 2.86e-51 Alzheimer's disease (late onset); BRCA cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg03517284 chr6:25882590 NA -0.34 -7.89 -0.3 1.34e-14 Height; BRCA cis rs5758511 0.689 rs55906806 chr22:42644471 C/T cg15128208 chr22:42549153 NA 0.48 7.82 0.3 2.15e-14 Birth weight; BRCA cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA trans rs7615952 0.576 rs2276727 chr3:125826243 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -11.1 -0.4 2.72e-26 Blood pressure (smoking interaction); BRCA cis rs17376456 0.877 rs12716457 chr5:93397627 T/C cg21475434 chr5:93447410 FAM172A 0.69 8.65 0.32 4.2e-17 Diabetic retinopathy; BRCA cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg13319975 chr6:146136371 FBXO30 -0.35 -8.16 -0.31 1.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9283706 0.641 rs6414805 chr5:66322600 T/C cg11590213 chr5:66331682 MAST4 0.42 8.09 0.3 3.09e-15 Coronary artery disease; BRCA cis rs8010715 0.816 rs6573565 chr14:24594733 A/G cg23112188 chr14:24563095 PCK2 0.34 8.4 0.32 2.98e-16 IgG glycosylation; BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -12.94 -0.46 3.67e-34 Platelet count; BRCA cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg21573476 chr21:45109991 RRP1B -0.37 -8.8 -0.33 1.25e-17 Mean corpuscular volume; BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg14004847 chr7:1930337 MAD1L1 0.45 9.81 0.36 3.03e-21 Bipolar disorder and schizophrenia; BRCA cis rs637571 0.726 rs669371 chr11:65674153 G/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.42 -8.46 -0.32 1.89e-16 Eosinophil percentage of white cells; BRCA cis rs2974760 0.606 rs2858918 chr16:201183 T/C cg08400316 chr16:204221 HBZ 0.76 16.49 0.55 3.72e-51 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs11758351 1.000 rs76722536 chr6:26192946 C/G cg01420254 chr6:26195488 NA 0.61 9.22 0.34 4.28e-19 Gout;Renal underexcretion gout; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13012494 chr21:47604986 C21orf56 -0.44 -9.1 -0.34 1.15e-18 Testicular germ cell tumor; BRCA cis rs6543140 0.929 rs6742530 chr2:103082280 G/A cg04239558 chr2:103089729 SLC9A4 0.35 9.74 0.36 5.21e-21 Blood protein levels; BRCA cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg00750074 chr16:89608354 SPG7 -0.42 -11.61 -0.42 2.13e-28 Multiple myeloma (IgH translocation); BRCA trans rs3733585 0.664 rs28602527 chr4:9958327 G/A cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg05863683 chr7:1912471 MAD1L1 -0.44 -9.57 -0.35 2.34e-20 Bipolar disorder and schizophrenia; BRCA cis rs73242632 1.000 rs10002090 chr4:57859592 T/C cg20415529 chr4:57845134 POLR2B;C4orf14 0.7 8.49 0.32 1.49e-16 Congenital heart disease (maternal effect); BRCA cis rs6733011 0.578 rs1581250 chr2:99500750 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.37 -8.56 -0.32 8.41e-17 Bipolar disorder; BRCA cis rs9790314 0.905 rs6789388 chr3:160970437 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.36 -0.49 9.48e-41 Morning vs. evening chronotype; BRCA cis rs495337 0.736 rs483508 chr20:48499609 C/T cg17835207 chr20:48524531 SPATA2 -0.54 -12.01 -0.43 4.03e-30 Psoriasis; BRCA trans rs656319 0.564 rs11776035 chr8:10071527 A/G cg06636001 chr8:8085503 FLJ10661 -0.46 -8.74 -0.33 2.08e-17 Myopia (pathological); BRCA cis rs250677 0.687 rs36046 chr5:148441257 A/C cg18129178 chr5:148520854 ABLIM3 -0.58 -11.93 -0.43 9.28e-30 Breast cancer; BRCA cis rs490234 0.702 rs4838279 chr9:128411726 G/A cg14078157 chr9:128172775 NA -0.51 -11.3 -0.41 3.88e-27 Mean arterial pressure; BRCA cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg05623727 chr3:50126028 RBM5 -0.42 -10.04 -0.37 3.92e-22 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.96 0.37 8.41e-22 Bipolar disorder; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg11843238 chr5:131593191 PDLIM4 0.35 9.12 0.34 9.57e-19 Breast cancer; BRCA cis rs7086627 0.515 rs7907969 chr10:82153005 T/A cg01528321 chr10:82214614 TSPAN14 0.67 14.14 0.49 1.03e-39 Post bronchodilator FEV1; BRCA cis rs10911232 0.507 rs4652772 chr1:183023696 C/G ch.1.3577855R chr1:183094577 LAMC1 -0.62 -16.34 -0.54 2.1e-50 Hypertriglyceridemia; BRCA cis rs11098499 0.739 rs9884728 chr4:120127079 C/T cg09307838 chr4:120376055 NA -0.49 -9.26 -0.34 3.11e-19 Corneal astigmatism; BRCA cis rs7020830 0.825 rs10973248 chr9:37197768 C/T cg14294708 chr9:37120828 ZCCHC7 1.16 41.16 0.85 7e-182 Schizophrenia; BRCA cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg08085267 chr17:45401833 C17orf57 -0.58 -12.06 -0.43 2.66e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg08999081 chr20:33150536 PIGU 0.49 13.78 0.48 5.24e-38 Coronary artery disease; BRCA cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg24399712 chr22:39784796 NA -0.47 -10.42 -0.38 1.33e-23 Intelligence (multi-trait analysis); BRCA cis rs4819052 1.000 rs13052356 chr21:46663588 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 14.8 0.51 7.89e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7249142 0.549 rs1858846 chr19:19281187 T/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.29 -0.41 4.46e-27 IgG glycosylation; BRCA cis rs589448 0.902 rs315113 chr12:69786543 G/T cg20891283 chr12:69753455 YEATS4 -0.83 -28.36 -0.75 3.84e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs7615952 0.641 rs7640158 chr3:125808011 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -10.82 -0.39 3.47e-25 Blood pressure (smoking interaction); BRCA cis rs36051895 0.695 rs2183137 chr9:5026293 A/G cg02405213 chr9:5042618 JAK2 -0.5 -9.11 -0.34 1.08e-18 Pediatric autoimmune diseases; BRCA cis rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05901451 chr6:126070800 HEY2 -0.53 -13.46 -0.47 1.6e-36 Brugada syndrome; BRCA cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.24 -0.31 9.46e-16 Aortic root size; BRCA cis rs208515 0.525 rs10498841 chr6:66663706 C/T cg07460842 chr6:66804631 NA 0.84 15.17 0.51 1.22e-44 Exhaled nitric oxide levels; BRCA cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg15605315 chr1:45957053 TESK2 0.47 9.9 0.36 1.33e-21 High light scatter reticulocyte count; BRCA cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.34 0.31 4.41e-16 Mean platelet volume; BRCA cis rs2370759 0.945 rs10508773 chr10:32575444 C/T cg18270830 chr10:32634957 EPC1 0.58 10.04 0.37 4.01e-22 Sexual dysfunction (female); BRCA cis rs3768617 0.510 rs4651139 chr1:183091963 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.08e-57 Fuchs's corneal dystrophy; BRCA cis rs11249608 0.636 rs13359572 chr5:178449276 T/C cg21905437 chr5:178450457 ZNF879 0.51 10.66 0.39 1.59e-24 Pubertal anthropometrics; BRCA trans rs911555 0.755 rs1138400 chr14:103956833 A/G cg17675199 chr6:35436792 RPL10A 0.3 7.89 0.3 1.31e-14 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.693 rs6668311 chr1:152964586 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.57 -0.35 2.28e-20 Inflammatory skin disease; BRCA cis rs921968 0.509 rs3856548 chr2:219398164 C/T cg02176678 chr2:219576539 TTLL4 -0.5 -12.76 -0.45 2.32e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs367943 0.901 rs463167 chr5:112799369 C/A cg12552261 chr5:112820674 MCC -0.55 -12.22 -0.44 4.98e-31 Type 2 diabetes; BRCA cis rs3857067 0.806 rs17302300 chr4:95109177 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.39 -0.35 1.02e-19 QT interval; BRCA cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg05207973 chr5:176823642 SLC34A1 -0.35 -8.23 -0.31 1.06e-15 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs1580019 0.961 rs3801328 chr7:32496930 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.29 0.54 3.92e-50 Cognitive ability; BRCA cis rs273218 1.000 rs273217 chr5:53380938 A/G ch.5.1024479R chr5:53302184 ARL15 0.42 8.68 0.32 3.36e-17 Migraine; BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg24829409 chr8:58192753 C8orf71 -0.5 -8.23 -0.31 1.06e-15 Developmental language disorder (linguistic errors); BRCA cis rs9814567 1.000 rs7619451 chr3:134233238 A/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -8.7 -0.33 2.74e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7091068 0.671 rs620890 chr10:95405424 G/A cg20715218 chr10:95462985 C10orf4 -0.47 -8.44 -0.32 2.05e-16 Urinary tract infection frequency; BRCA cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg15595755 chr5:1867978 NA 0.36 8.6 0.32 6.23e-17 Cardiovascular disease risk factors; BRCA cis rs477692 0.699 rs576175 chr10:131386408 A/T cg24747557 chr10:131355152 MGMT -0.35 -8.53 -0.32 1.1e-16 Response to temozolomide; BRCA cis rs6840360 0.593 rs6857073 chr4:152689274 A/G cg22705602 chr4:152727874 NA 0.39 10.2 0.37 1.01e-22 Intelligence (multi-trait analysis); BRCA cis rs13064411 0.696 rs7622740 chr3:113206771 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -12.0 -0.43 4.67e-30 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs4787491 0.729 rs4238960 chr16:30038648 G/C cg06326092 chr16:30034487 C16orf92 0.38 9.62 0.36 1.47e-20 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg11062466 chr8:58055876 NA 0.57 9.5 0.35 4.18e-20 Developmental language disorder (linguistic errors); BRCA cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.93 13.64 0.47 2.27e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2249625 0.564 rs2463734 chr6:72882558 C/T cg18830697 chr6:72922368 RIMS1 -0.63 -14.36 -0.49 9.82e-41 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg22963979 chr7:1858916 MAD1L1 -0.37 -8.01 -0.3 5.36e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs35110281 0.667 rs4819288 chr21:45120173 C/G cg01579765 chr21:45077557 HSF2BP -0.4 -10.05 -0.37 3.78e-22 Mean corpuscular volume; BRCA cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg11764359 chr7:65958608 NA 0.63 11.25 0.41 6.34e-27 Aortic root size; BRCA trans rs7613875 0.578 rs4688753 chr3:50074773 A/G cg21659725 chr3:3221576 CRBN -0.35 -8.7 -0.33 2.74e-17 Body mass index; BRCA cis rs4319547 0.695 rs1973463 chr12:122938003 A/G cg05707623 chr12:122985044 ZCCHC8 -0.42 -8.35 -0.31 4.25e-16 Body mass index; BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg22920501 chr2:26401640 FAM59B -0.82 -13.65 -0.48 2.16e-37 Gut microbiome composition (summer); BRCA trans rs11250097 0.549 rs11778177 chr8:11310362 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -10.45 -0.38 1.07e-23 Neuroticism; BRCA cis rs6138458 0.961 rs11700073 chr20:24975215 C/G cg26195577 chr20:24973756 C20orf3 1.02 28.56 0.75 2.91e-116 Blood protein levels; BRCA trans rs61931739 0.533 rs7970871 chr12:33917301 G/A cg26384229 chr12:38710491 ALG10B 0.4 8.98 0.33 3.05e-18 Morning vs. evening chronotype; BRCA cis rs2842992 0.830 rs2758320 chr6:160070676 T/G cg16489826 chr6:160211363 TCP1;MRPL18 0.53 11.02 0.4 5.47e-26 Age-related macular degeneration (geographic atrophy); BRCA cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg06671706 chr8:8559999 CLDN23 0.45 8.74 0.33 2.11e-17 Obesity-related traits; BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg14196790 chr5:131705035 SLC22A5 0.3 7.87 0.3 1.56e-14 Breast cancer; BRCA cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg23895963 chr12:117471115 NA 0.5 9.14 0.34 8e-19 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg22875332 chr1:76189707 ACADM -0.71 -15.45 -0.52 5.21e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2011503 1.000 rs1989867 chr19:19447470 A/G cg11584989 chr19:19387371 SF4 -0.65 -14.01 -0.48 4.3e-39 Bipolar disorder; BRCA cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.42 0.41 1.26e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.15e-15 Alzheimer's disease (late onset); BRCA cis rs1577917 0.682 rs1173419 chr6:86402163 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -13.63 -0.47 2.63e-37 Response to antipsychotic treatment; BRCA cis rs3733585 0.806 rs7375599 chr4:9954918 C/T cg00071950 chr4:10020882 SLC2A9 0.53 13.41 0.47 2.6e-36 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg05535760 chr7:792225 HEATR2 -0.72 -11.51 -0.41 5.51e-28 Cerebrospinal P-tau181p levels; BRCA cis rs6940638 0.531 rs12211984 chr6:26986054 G/C cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Intelligence (multi-trait analysis); BRCA cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg12591125 chr7:1885375 MAD1L1 0.49 8.64 0.32 4.52e-17 Bipolar disorder; BRCA cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.53 -8.46 -0.32 1.77e-16 Schizophrenia; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg21782813 chr7:2030301 MAD1L1 0.41 11.89 0.43 1.4e-29 Bipolar disorder and schizophrenia; BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg22963979 chr7:1858916 MAD1L1 -0.38 -8.03 -0.3 4.63e-15 Bipolar disorder and schizophrenia; BRCA cis rs9790314 1.000 rs6441373 chr3:161026717 T/G cg03342759 chr3:160939853 NMD3 -0.64 -13.47 -0.47 1.36e-36 Morning vs. evening chronotype; BRCA cis rs6570726 0.905 rs377143 chr6:145834220 C/T cg23711669 chr6:146136114 FBXO30 0.65 14.84 0.51 4.91e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs881375 0.967 rs3761849 chr9:123690957 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 8.85 0.33 8.38e-18 Rheumatoid arthritis; BRCA cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -9.76 -0.36 4.42e-21 Mean corpuscular volume; BRCA cis rs853679 0.542 rs2295594 chr6:28053097 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Depression; BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs4363385 0.747 rs3964619 chr1:152972811 A/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.52 -0.35 3.44e-20 Inflammatory skin disease; BRCA cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.12 0.31 2.49e-15 Menopause (age at onset); BRCA cis rs6910061 1.000 rs5027679 chr6:11118871 A/G cg27233058 chr6:11094804 LOC221710 -0.52 -9.11 -0.34 1.01e-18 Diabetic kidney disease; BRCA cis rs9814567 1.000 rs7630874 chr3:134293291 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.85e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11577318 0.853 rs7537477 chr1:26618829 C/T cg07461501 chr17:79650226 HGS;ARL16 0.4 10.23 0.38 7.26e-23 Granulocyte percentage of myeloid white cells; BRCA cis rs7246760 0.867 rs16981648 chr19:9804424 A/C cg16876255 chr19:9731953 ZNF561 0.63 7.83 0.3 1.98e-14 Pursuit maintenance gain; BRCA cis rs3008870 0.959 rs56707923 chr1:67388016 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.72 0.65 9.17e-79 Lymphocyte percentage of white cells; BRCA cis rs7727544 0.904 rs58835386 chr5:131600559 A/G cg12564285 chr5:131593104 PDLIM4 0.32 8.23 0.31 1.09e-15 Blood metabolite levels; BRCA cis rs6912958 0.559 rs242279 chr6:88048191 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.57 11.98 0.43 5.5e-30 Monocyte percentage of white cells; BRCA cis rs6120849 0.707 rs3746444 chr20:33578251 A/G cg24642439 chr20:33292090 TP53INP2 0.58 10.04 0.37 4.04e-22 Protein C levels; BRCA cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg08917208 chr2:24149416 ATAD2B 0.91 13.38 0.47 3.55e-36 Lymphocyte counts; BRCA cis rs3862030 0.720 rs3740415 chr10:104232716 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.18e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs858239 0.636 rs7808488 chr7:23221870 T/C cg23682824 chr7:23144976 KLHL7 0.32 8.18 0.31 1.56e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg05729581 chr11:3078854 CARS -0.35 -8.51 -0.32 1.22e-16 Longevity; BRCA cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg18404041 chr3:52824283 ITIH1 -0.36 -11.18 -0.4 1.23e-26 Electroencephalogram traits; BRCA cis rs11105298 0.786 rs10858897 chr12:89922032 C/A cg00757033 chr12:89920650 WDR51B 0.54 11.16 0.4 1.56e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs783540 0.934 rs803747 chr15:83258096 A/G cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.44 -0.32 2.05e-16 Schizophrenia; BRCA trans rs6964833 0.935 rs35735900 chr7:74066227 T/C cg07504079 chr7:72649617 NCF1B -0.47 -9.17 -0.34 6.61e-19 Menarche (age at onset); BRCA cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -17.91 -0.58 1.88e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.3 -0.31 6.2e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9287719 0.967 rs759402 chr2:10729554 A/T cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.03e-23 Prostate cancer; BRCA cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.679 rs3756225 chr4:10094133 G/C cg00071950 chr4:10020882 SLC2A9 -0.52 -12.59 -0.45 1.23e-32 Bone mineral density; BRCA trans rs11098499 0.820 rs11737395 chr4:120520704 C/G cg25214090 chr10:38739885 LOC399744 0.52 11.49 0.41 6.72e-28 Corneal astigmatism; BRCA cis rs7095944 0.614 rs11245354 chr10:126450125 C/A cg08799069 chr10:126477246 METTL10 -0.4 -10.16 -0.37 1.43e-22 Asthma; BRCA cis rs2882667 0.690 rs6873425 chr5:138155245 G/A cg04439458 chr5:138467593 SIL1 0.32 8.14 0.31 2.11e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg25036284 chr2:26402008 FAM59B -0.9 -15.23 -0.52 6.86e-45 Gut microbiome composition (summer); BRCA trans rs3749237 1.000 rs2291542 chr3:49751585 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.16 0.34 6.73e-19 Resting heart rate; BRCA cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg11833968 chr6:79620685 NA -0.45 -10.02 -0.37 4.82e-22 Intelligence (multi-trait analysis); BRCA cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg05623727 chr3:50126028 RBM5 -0.49 -12.16 -0.43 9.5e-31 Body mass index; BRCA cis rs701145 0.585 rs357477 chr3:153892717 A/G cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.9e-18 Coronary artery disease; BRCA trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.13 0.34 8.77e-19 Resting heart rate; BRCA cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg21395723 chr22:39101663 GTPBP1 0.39 8.33 0.31 4.9e-16 Menopause (age at onset); BRCA cis rs8170 0.603 rs10259 chr19:17430915 G/A cg02455703 chr19:17412272 ABHD8 -0.35 -7.85 -0.3 1.71e-14 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs13631 0.928 rs9411308 chr9:140000115 C/T cg03717367 chr9:139980219 LOC100289341;MAN1B1 0.38 8.87 0.33 7.32e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs6684514 0.961 rs10908497 chr1:156274740 G/A cg16558208 chr1:156270281 VHLL 0.36 8.42 0.32 2.48e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.76 12.59 0.45 1.2e-32 Schizophrenia; BRCA cis rs6964587 1.000 rs7797834 chr7:91743150 C/T cg01689657 chr7:91764605 CYP51A1 -0.23 -8.33 -0.31 5.08e-16 Breast cancer; BRCA cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg01262667 chr19:19385393 TM6SF2 -0.42 -10.79 -0.39 4.77e-25 Tonsillectomy; BRCA trans rs1997103 1.000 rs10263552 chr7:55404747 C/T cg20935933 chr6:143382018 AIG1 0.6 11.63 0.42 1.73e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9300255 0.602 rs2851435 chr12:123712416 G/A cg00376283 chr12:123451042 ABCB9 0.49 10.09 0.37 2.64e-22 Neutrophil percentage of white cells; BRCA cis rs2836974 0.666 rs1888487 chr21:40683259 A/G cg22974920 chr21:40686053 BRWD1 -0.39 -8.57 -0.32 8.01e-17 Cognitive function; BRCA cis rs1371614 0.635 rs877273 chr2:27140022 C/T cg12368169 chr2:27073192 DPYSL5 -0.3 -8.85 -0.33 8.5e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg02659138 chr7:134003124 SLC35B4 0.38 11.37 0.41 2.02e-27 Mean platelet volume; BRCA cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg11279151 chr3:101281821 RG9MTD1 0.38 8.63 0.32 4.79e-17 Colorectal cancer; BRCA cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg11266682 chr4:10021025 SLC2A9 0.46 12.3 0.44 2.43e-31 Bone mineral density; BRCA cis rs875971 0.862 rs6460306 chr7:66060793 T/C cg18876405 chr7:65276391 NA -0.5 -11.18 -0.4 1.29e-26 Aortic root size; BRCA cis rs7617773 0.780 rs11716848 chr3:48378500 G/A cg11946769 chr3:48343235 NME6 0.67 13.46 0.47 1.62e-36 Coronary artery disease; BRCA cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg13271783 chr10:134563150 INPP5A -0.48 -9.63 -0.36 1.38e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs12220238 0.908 rs10824124 chr10:75997360 C/G cg19889307 chr10:75911429 ADK;AP3M1 0.49 7.99 0.3 6.44e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg18876405 chr7:65276391 NA -0.55 -13.25 -0.46 1.36e-35 Aortic root size; BRCA cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs6960043 0.818 rs10267273 chr7:15053589 A/G cg19272540 chr7:15055459 NA -0.23 -8.11 -0.31 2.64e-15 Type 2 diabetes; BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg16606324 chr3:10149918 C3orf24 0.54 10.48 0.38 8.25e-24 Alzheimer's disease; BRCA trans rs2204008 0.701 rs3898237 chr12:38219714 A/G cg06521331 chr12:34319734 NA -0.54 -9.78 -0.36 3.7e-21 Bladder cancer; BRCA trans rs61931739 0.534 rs10844774 chr12:34166764 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.7 0.36 7.46e-21 Morning vs. evening chronotype; BRCA cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg09658497 chr7:2847517 GNA12 -0.41 -8.69 -0.33 3.04e-17 Height; BRCA cis rs36051895 0.594 rs7029244 chr9:5180961 A/C cg02405213 chr9:5042618 JAK2 -0.48 -9.39 -0.35 1.04e-19 Pediatric autoimmune diseases; BRCA cis rs7267979 1.000 rs2500404 chr20:25359758 A/C cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7246657 0.722 rs2927739 chr19:38149330 C/A cg18154014 chr19:37997991 ZNF793 -0.49 -9.15 -0.34 7.26e-19 Coronary artery calcification; BRCA cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg20701182 chr2:24300061 SF3B14 0.62 8.86 0.33 8.1e-18 Lymphocyte counts; BRCA trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg23533926 chr12:111358616 MYL2 0.41 8.64 0.32 4.59e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg03354898 chr7:1950403 MAD1L1 -0.46 -9.81 -0.36 2.99e-21 Schizophrenia; BRCA cis rs11997175 0.846 rs11776207 chr8:33765126 G/T ch.8.33884649F chr8:33765107 NA -0.42 -9.71 -0.36 7.1e-21 Body mass index; BRCA cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg10523679 chr1:76189770 ACADM 0.67 12.47 0.44 4.11e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs61931739 0.500 rs11053211 chr12:34464334 T/C cg06521331 chr12:34319734 NA -0.52 -10.19 -0.37 1.12e-22 Morning vs. evening chronotype; BRCA cis rs17253792 0.822 rs10483650 chr14:56145312 A/G cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs11971779 0.680 rs4728465 chr7:139069061 G/A cg07862535 chr7:139043722 LUC7L2 0.41 11.16 0.4 1.46e-26 Diisocyanate-induced asthma; BRCA cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg17971929 chr21:40555470 PSMG1 0.77 18.02 0.58 5.08e-59 Cognitive function; BRCA cis rs35146811 0.625 rs2906645 chr7:99817859 A/G cg22906224 chr7:99728672 NA -0.43 -8.04 -0.3 4.29e-15 Coronary artery disease; BRCA cis rs2688608 0.592 rs3849967 chr10:75483366 C/T cg23231163 chr10:75533350 FUT11 -0.34 -8.83 -0.33 9.85e-18 Inflammatory bowel disease; BRCA cis rs7818345 0.967 rs11787230 chr8:19280982 C/G cg11303988 chr8:19266685 CSGALNACT1 0.31 8.04 0.3 4.28e-15 Language performance in older adults (adjusted for episodic memory); BRCA trans rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA cis rs58804349 0.581 rs12221397 chr10:43239833 A/G cg08461752 chr10:43522343 NA 0.66 9.43 0.35 7.57e-20 Pediatric bone mineral content (radius); BRCA cis rs2559856 0.935 rs7970952 chr12:102081577 C/T cg12213457 chr12:102090980 CHPT1 -0.37 -8.05 -0.3 4.16e-15 Blood protein levels; BRCA cis rs2505998 0.843 rs2435344 chr10:43585874 T/C cg15436174 chr10:43711423 RASGEF1A -0.42 -8.39 -0.32 3.06e-16 Hirschsprung disease; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg10729496 chr3:10149963 C3orf24 0.41 7.88 0.3 1.44e-14 Alzheimer's disease; BRCA cis rs8177179 0.505 rs1405023 chr3:133481128 T/C cg12373951 chr3:133503437 NA -0.32 -8.12 -0.31 2.35e-15 Iron status biomarkers (transferrin levels); BRCA cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg20476274 chr7:133979776 SLC35B4 0.68 20.42 0.63 9.97e-72 Mean platelet volume; BRCA cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg12463550 chr7:65579703 CRCP 0.37 7.93 0.3 9.93e-15 Aortic root size; BRCA cis rs6964587 0.967 rs2299235 chr7:91627500 C/T cg17063962 chr7:91808500 NA 0.52 12.37 0.44 1.15e-31 Breast cancer; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.74 11.17 0.4 1.41e-26 Platelet count; BRCA cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 4.05e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg14343924 chr8:8086146 FLJ10661 0.39 8.19 0.31 1.4e-15 Mood instability; BRCA cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg01849466 chr14:104193079 ZFYVE21 0.47 10.6 0.39 2.59e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs7772486 0.754 rs697055 chr6:146003790 C/G cg23711669 chr6:146136114 FBXO30 0.79 18.77 0.6 6.37e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs7590368 1.000 rs72779469 chr2:10963764 C/G cg15705551 chr2:10952987 PDIA6 0.43 8.05 0.3 3.97e-15 Educational attainment (years of education); BRCA cis rs6831352 0.693 rs2602875 chr4:100039495 C/G cg12011299 chr4:100065546 ADH4 0.42 10.53 0.38 4.9e-24 Alcohol dependence; BRCA cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg27446573 chr6:127587934 RNF146 0.9 21.07 0.64 2.99e-75 Breast cancer; BRCA cis rs6831352 0.837 rs2924583 chr4:100044640 T/C cg13256891 chr4:100009986 ADH5 0.52 9.77 0.36 4.15e-21 Alcohol dependence; BRCA trans rs1941687 0.524 rs6507062 chr18:31374197 G/C cg27147174 chr7:100797783 AP1S1 -0.52 -10.53 -0.38 5.27e-24 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs2549003 1.000 rs9282762 chr5:131822055 T/C cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg01028140 chr2:1542097 TPO -0.62 -11.87 -0.43 1.67e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg14926445 chr8:58193284 C8orf71 -0.42 -8.19 -0.31 1.43e-15 Developmental language disorder (linguistic errors); BRCA cis rs7246760 0.867 rs55800282 chr19:9833530 A/G cg16876255 chr19:9731953 ZNF561 0.64 7.92 0.3 1.07e-14 Pursuit maintenance gain; BRCA trans rs1478897 0.575 rs12679960 chr8:11430990 C/T cg15556689 chr8:8085844 FLJ10661 0.37 8.93 0.33 4.6e-18 Systemic lupus erythematosus; BRCA cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.68e-24 Motion sickness; BRCA trans rs9291683 0.935 rs1860910 chr4:10275470 T/G cg26043149 chr18:55253948 FECH 0.39 8.92 0.33 4.71e-18 Bone mineral density; BRCA cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg07493874 chr5:1342172 CLPTM1L -0.5 -14.02 -0.49 3.9e-39 Lung cancer; BRCA cis rs1003719 0.762 rs11088381 chr21:38478429 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs17401966 0.838 rs1538557 chr1:10297230 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.95 0.48 8.64e-39 Hepatocellular carcinoma; BRCA cis rs1941023 0.503 rs894591 chr11:60132647 T/C cg08716584 chr11:60157161 MS4A7 -0.43 -9.92 -0.37 1.13e-21 Congenital heart disease (maternal effect); BRCA cis rs12618769 0.625 rs72819984 chr2:99044762 G/C cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.71e-15 Bipolar disorder; BRCA cis rs16867321 0.950 rs9677293 chr2:181499459 C/G cg23363182 chr2:181467187 NA -0.44 -8.39 -0.31 3.16e-16 Obesity; BRCA cis rs7772486 0.774 rs6930181 chr6:146180974 A/T cg23711669 chr6:146136114 FBXO30 -0.66 -15.17 -0.51 1.22e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7481584 0.624 rs12417389 chr11:3035304 G/C cg08508325 chr11:3079039 CARS 0.27 8.26 0.31 8.3e-16 Calcium levels; BRCA cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1538970 0.884 rs781232 chr1:45890399 C/T cg05343316 chr1:45956843 TESK2 -0.55 -11.39 -0.41 1.69e-27 Platelet count; BRCA trans rs7647973 0.710 rs11130207 chr3:49611666 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.86 -0.3 1.65e-14 Menarche (age at onset); BRCA cis rs11971779 0.638 rs77668044 chr7:139111085 T/A cg07862535 chr7:139043722 LUC7L2 0.51 11.99 0.43 5.25e-30 Diisocyanate-induced asthma; BRCA cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg10560079 chr2:191398806 TMEM194B 0.39 8.58 0.32 7.06e-17 Pulse pressure; BRCA cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg18132916 chr6:79620363 NA -0.5 -11.48 -0.41 7.25e-28 Intelligence (multi-trait analysis); BRCA cis rs7659604 0.702 rs6815790 chr4:122695385 A/C cg19748678 chr4:122722346 EXOSC9 0.64 13.82 0.48 3.26e-38 Type 2 diabetes; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs6066835 1.000 rs73138221 chr20:47349525 T/C cg18078177 chr20:47281410 PREX1 0.72 8.47 0.32 1.72e-16 Multiple myeloma; BRCA cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg16230307 chr14:35515116 FAM177A1 0.74 15.31 0.52 2.52e-45 Psoriasis; BRCA trans rs877282 0.853 rs12763400 chr10:763617 C/T cg22713356 chr15:30763199 NA 1.32 24.9 0.7 3.56e-96 Uric acid levels; BRCA cis rs2797160 1.000 rs4897153 chr6:126003403 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.42 -0.35 7.86e-20 Endometrial cancer; BRCA cis rs514406 0.526 rs835608 chr1:53169758 T/A cg24675658 chr1:53192096 ZYG11B 0.72 16.81 0.55 9.31e-53 Monocyte count; BRCA cis rs7582720 1.000 rs72936326 chr2:204054141 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.22 0.44 5.16e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs4711336 0.967 rs4711338 chr6:33660188 T/C cg14003231 chr6:33640908 ITPR3 0.32 7.87 0.3 1.53e-14 Height; BRCA cis rs7552404 1.000 rs1498312 chr1:76177849 C/T cg03433033 chr1:76189801 ACADM 0.76 17.3 0.56 2.91e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs730775 0.505 rs324137 chr6:44273546 G/T cg21130236 chr6:44246755 TMEM151B 0.29 8.38 0.31 3.36e-16 Monocyte percentage of white cells;Monocyte count; BRCA cis rs400736 0.535 rs4418631 chr1:8174197 A/G cg25007680 chr1:8021821 PARK7 0.36 8.96 0.33 3.67e-18 Response to antidepressants and depression; BRCA cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg05985134 chr18:33552581 C18orf21 0.64 12.46 0.44 4.72e-32 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.93 -0.33 4.47e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg14196790 chr5:131705035 SLC22A5 -0.41 -10.1 -0.37 2.35e-22 Breast cancer;Mosquito bite size; BRCA cis rs35110281 0.782 rs6518302 chr21:45018478 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.52 -0.35 3.37e-20 Mean corpuscular volume; BRCA cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg25019033 chr10:957182 NA -0.41 -7.89 -0.3 1.3e-14 Eosinophil percentage of granulocytes; BRCA cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg16586182 chr3:47516702 SCAP -0.53 -11.71 -0.42 7.64e-29 Colorectal cancer; BRCA cis rs9469890 0.604 rs11758471 chr6:34503517 A/C cg17674042 chr6:34482479 PACSIN1 -0.33 -8.56 -0.32 8.1e-17 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg10523679 chr1:76189770 ACADM 0.72 12.55 0.44 1.88e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2637030 0.515 rs449160 chr5:53005969 A/G cg06476337 chr5:52856530 NDUFS4 0.37 8.47 0.32 1.63e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA trans rs9467711 0.606 rs9393718 chr6:26407482 G/A cg01620082 chr3:125678407 NA -0.62 -8.23 -0.31 1.05e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs1538970 0.962 rs3219472 chr1:45804050 A/G cg05343316 chr1:45956843 TESK2 -0.49 -9.25 -0.34 3.35e-19 Platelet count; BRCA trans rs8073060 0.586 rs117573546 chr17:33909588 G/A cg19694781 chr19:47549865 TMEM160 1.05 21.57 0.65 5.93e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg18132916 chr6:79620363 NA -0.38 -7.81 -0.3 2.32e-14 Intelligence (multi-trait analysis); BRCA cis rs74181299 0.892 rs2540945 chr2:65289825 A/G cg05010058 chr2:65284262 CEP68 0.3 8.43 0.32 2.34e-16 Pulse pressure; BRCA cis rs7737355 1.000 rs12517604 chr5:130748500 T/C cg06307176 chr5:131281290 NA -0.5 -9.87 -0.36 1.8e-21 Life satisfaction; BRCA cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 13.95 0.48 8.64e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4363385 0.747 rs4319267 chr1:152972699 T/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.52 -0.35 3.44e-20 Inflammatory skin disease; BRCA cis rs17253792 0.915 rs28375514 chr14:56179941 G/A cg01858014 chr14:56050164 KTN1 -0.67 -8.51 -0.32 1.22e-16 Putamen volume; BRCA cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg05025164 chr4:1340916 KIAA1530 0.76 15.5 0.52 3.12e-46 Longevity; BRCA cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg15103426 chr22:29168792 CCDC117 0.52 12.3 0.44 2.39e-31 Lymphocyte counts; BRCA cis rs8017423 0.647 rs4904677 chr14:90819245 C/T cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg13319975 chr6:146136371 FBXO30 -0.4 -9.14 -0.34 8.3e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg25517755 chr10:38738941 LOC399744 -0.37 -7.87 -0.3 1.53e-14 Corneal astigmatism; BRCA cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.24e-23 Motion sickness; BRCA cis rs2535633 0.820 rs7626551 chr3:52938092 C/G cg11645453 chr3:52864694 ITIH4 -0.35 -9.42 -0.35 8.1e-20 Body mass index; BRCA cis rs2370759 1.000 rs79578760 chr10:32611264 C/A cg18270830 chr10:32634957 EPC1 0.58 10.07 0.37 3.08e-22 Sexual dysfunction (female); BRCA cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.48e-61 Cognitive function; BRCA cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11644478 chr21:40555479 PSMG1 -0.7 -15.79 -0.53 1.2e-47 Cognitive function; BRCA cis rs2797160 0.904 rs1418637 chr6:125992553 A/G cg05901451 chr6:126070800 HEY2 -0.43 -10.17 -0.37 1.3e-22 Endometrial cancer; BRCA cis rs7493 1.000 rs1034809 chr7:95051652 G/A cg19678392 chr7:94953810 PON1 -0.42 -8.67 -0.32 3.47e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs72781680 0.593 rs72797817 chr2:24350569 A/G cg06627628 chr2:24431161 ITSN2 -0.5 -8.08 -0.3 3.35e-15 Lymphocyte counts; BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 18.43 0.59 3.66e-61 Platelet count; BRCA cis rs4631830 0.720 rs11004415 chr10:51498181 G/A cg20129853 chr10:51489980 NA 0.32 8.66 0.32 3.98e-17 Prostate-specific antigen levels; BRCA cis rs34734847 0.871 rs2239760 chr12:121163518 C/A cg21892295 chr12:121157589 UNC119B -0.42 -12.8 -0.45 1.45e-33 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs10890376 chr1:46406582 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.75 0.42 5.51e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7100689 0.646 rs1815650 chr10:82157464 C/T cg01528321 chr10:82214614 TSPAN14 0.85 18.93 0.6 8.63e-64 Post bronchodilator FEV1; BRCA cis rs7020830 0.931 rs7034554 chr9:37081301 A/G cg14294708 chr9:37120828 ZCCHC7 1.16 40.86 0.85 2.1e-180 Schizophrenia; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00149659 chr3:10157352 C3orf10 0.77 13.17 0.46 3.36e-35 Alzheimer's disease; BRCA cis rs7772486 0.754 rs6570708 chr6:145989428 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -8.38 -0.31 3.45e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs858239 0.600 rs1468592 chr7:23140647 C/T cg23682824 chr7:23144976 KLHL7 -0.45 -12.17 -0.43 8.74e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg01475377 chr6:109611718 NA -0.61 -17.05 -0.56 5.07e-54 Reticulocyte fraction of red cells; BRCA cis rs7131987 0.903 rs11050153 chr12:29405148 T/C cg09582351 chr12:29534625 ERGIC2 -0.4 -9.46 -0.35 5.71e-20 QT interval; BRCA cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.86 0.36 1.84e-21 Bipolar disorder; BRCA cis rs10782582 0.632 rs77099976 chr1:76240524 T/C cg03433033 chr1:76189801 ACADM -0.42 -7.89 -0.3 1.32e-14 Daytime sleep phenotypes; BRCA cis rs6450176 1.000 rs3776702 chr5:53305419 G/A ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.39 -0.52 1.09e-45 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg04511125 chr2:88470314 THNSL2 -0.72 -14.76 -0.5 1.24e-42 Response to metformin (IC50); BRCA cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg22834771 chr12:69754056 YEATS4 -0.37 -9.05 -0.34 1.68e-18 Blood protein levels; BRCA cis rs6831352 0.918 rs13133647 chr4:100058727 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs11955398 0.542 rs2085413 chr5:60025379 C/T cg02684056 chr5:59996105 DEPDC1B -0.38 -9.16 -0.34 6.96e-19 Intelligence (multi-trait analysis); BRCA trans rs6951245 0.554 rs76243429 chr7:1152543 C/T cg13565492 chr6:43139072 SRF -0.85 -15.37 -0.52 1.31e-45 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1577917 1.000 rs13217384 chr6:86720000 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.63 -0.45 8.28e-33 Response to antipsychotic treatment; BRCA cis rs7903847 0.642 rs11189178 chr10:99143272 T/G cg20016023 chr10:99160130 RRP12 -0.27 -8.61 -0.32 5.6e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg26224354 chr7:1096374 C7orf50;GPR146 0.39 8.3 0.31 6.42e-16 Longevity;Endometriosis; BRCA cis rs1882538 0.538 rs7783217 chr7:133104117 C/G cg10665199 chr7:133106180 EXOC4 -0.45 -9.63 -0.36 1.42e-20 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg01262667 chr19:19385393 TM6SF2 0.37 9.48 0.35 4.71e-20 Tonsillectomy; BRCA cis rs2760061 0.626 rs672977 chr1:228120288 A/C cg02753203 chr1:228287806 NA -0.6 -13.03 -0.46 1.4e-34 Diastolic blood pressure; BRCA cis rs1215050 0.755 rs2952911 chr4:98850666 T/C cg05340658 chr4:99064831 C4orf37 -0.43 -9.8 -0.36 3.27e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg02659138 chr7:134003124 SLC35B4 0.32 9.78 0.36 3.74e-21 Mean platelet volume; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.21 -0.34 4.43e-19 Total body bone mineral density; BRCA cis rs7572263 0.724 rs11676550 chr2:209053775 T/C cg23998903 chr2:209048830 C2orf80 -0.41 -8.45 -0.32 2.01e-16 Glioma;Non-glioblastoma glioma; BRCA cis rs3768617 0.811 rs4396114 chr1:183007441 C/T ch.1.3577855R chr1:183094577 LAMC1 0.44 9.47 0.35 5.11e-20 Fuchs's corneal dystrophy; BRCA cis rs4880487 0.888 rs10794731 chr10:1251905 T/A cg03183215 chr10:1252341 ADARB2 -0.38 -8.54 -0.32 1.01e-16 Migraine; BRCA cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg22974920 chr21:40686053 BRWD1 -0.39 -8.72 -0.33 2.41e-17 Cognitive function; BRCA cis rs877529 0.967 rs139406 chr22:39551798 T/C cg18708252 chr22:39545030 CBX7 -0.32 -8.19 -0.31 1.44e-15 Multiple myeloma; BRCA cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg08807101 chr21:30365312 RNF160 0.75 19.73 0.62 5.22e-68 Dental caries; BRCA trans rs35110281 0.715 rs969060 chr21:45080852 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.11 0.37 2.09e-22 Mean corpuscular volume; BRCA cis rs2204008 0.744 rs12099650 chr12:38317140 C/G cg13010199 chr12:38710504 ALG10B 0.45 9.22 0.34 4.16e-19 Bladder cancer; BRCA trans rs35110281 0.782 rs1454650 chr21:45012353 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.28 0.38 4.65e-23 Mean corpuscular volume; BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.88 0.62 8.13e-69 Platelet count; BRCA cis rs2032447 0.714 rs199736 chr6:25936787 C/T cg03517284 chr6:25882590 NA -0.44 -9.48 -0.35 4.93e-20 Intelligence (multi-trait analysis); BRCA cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.71 -10.41 -0.38 1.5e-23 Schizophrenia; BRCA cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg06784218 chr1:46089804 CCDC17 0.52 12.36 0.44 1.3e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9814567 0.806 rs1880375 chr3:134322163 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7635838 0.619 rs347614 chr3:11276399 T/C cg00170343 chr3:11313890 ATG7 0.42 8.07 0.3 3.44e-15 HDL cholesterol; BRCA cis rs11105298 0.891 rs12228177 chr12:89862030 G/T cg00757033 chr12:89920650 WDR51B 0.53 10.71 0.39 1.02e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs10752881 1.000 rs10752881 chr1:182973491 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.73 0.55 2.36e-52 Colorectal cancer; BRCA cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg11645453 chr3:52864694 ITIH4 0.49 11.98 0.43 5.43e-30 Schizophrenia; BRCA trans rs9467711 0.659 rs72844462 chr6:26563864 A/C cg01620082 chr3:125678407 NA -0.68 -8.38 -0.31 3.47e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg23708337 chr7:1209742 NA 0.48 8.14 0.31 2.11e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6964587 0.869 rs7793946 chr7:91520628 T/C cg17063962 chr7:91808500 NA -0.53 -12.12 -0.43 1.47e-30 Breast cancer; BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg08742575 chr21:47604166 C21orf56 0.41 8.01 0.3 5.51e-15 Testicular germ cell tumor; BRCA cis rs2559856 1.000 rs2695296 chr12:102085487 T/C cg12924262 chr12:102091054 CHPT1 0.36 8.17 0.31 1.66e-15 Blood protein levels; BRCA cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg18016565 chr1:150552671 MCL1 -0.4 -9.18 -0.34 5.95e-19 Tonsillectomy; BRCA cis rs992157 0.560 rs4674274 chr2:219089131 A/T cg00012203 chr2:219082015 ARPC2 -0.57 -12.03 -0.43 3.43e-30 Colorectal cancer; BRCA cis rs6450176 0.857 rs1541680 chr5:53304725 G/A ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.55 -0.52 1.79e-46 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2032447 0.839 rs9356995 chr6:25996673 G/A cg03517284 chr6:25882590 NA -0.41 -8.79 -0.33 1.38e-17 Intelligence (multi-trait analysis); BRCA cis rs2370759 1.000 rs79806114 chr10:32618022 T/C cg18270830 chr10:32634957 EPC1 0.61 10.46 0.38 9.64e-24 Sexual dysfunction (female); BRCA cis rs6987853 0.814 rs2923447 chr8:42439848 G/T cg09913449 chr8:42400586 C8orf40 0.37 7.8 0.3 2.44e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs4880487 0.888 rs7074199 chr10:1251022 C/T cg03183215 chr10:1252341 ADARB2 -0.38 -8.54 -0.32 1.01e-16 Migraine; BRCA cis rs514406 0.679 rs499239 chr1:53310594 A/G cg25767906 chr1:53392781 SCP2 -0.46 -10.31 -0.38 3.68e-23 Monocyte count; BRCA cis rs61931739 0.500 rs34703942 chr12:34583776 T/C cg06521331 chr12:34319734 NA 0.53 10.32 0.38 3.44e-23 Morning vs. evening chronotype; BRCA cis rs1832871 0.616 rs55675950 chr6:158773994 T/A cg07165851 chr6:158734300 TULP4 0.64 12.73 0.45 2.92e-33 Height; BRCA cis rs9810890 1.000 rs73196974 chr3:128449006 A/C cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.52 -10.97 -0.4 9.19e-26 Lymphocyte counts; BRCA cis rs4664304 0.649 rs12692570 chr2:160726599 C/T cg01092293 chr2:160761427 LY75 0.34 8.18 0.31 1.52e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.69 14.64 0.5 4.77e-42 Lymphocyte counts; BRCA trans rs561341 1.000 rs1681718 chr17:30296445 G/A cg27661571 chr11:113659931 NA -0.7 -10.88 -0.4 2e-25 Hip circumference adjusted for BMI; BRCA cis rs17270561 0.609 rs1317510 chr6:25778924 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 9.7 0.36 7.59e-21 Iron status biomarkers; BRCA cis rs2276314 0.857 rs72883058 chr18:33612917 G/A cg05985134 chr18:33552581 C18orf21 0.65 12.32 0.44 1.91e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg06766960 chr11:133703094 NA 0.48 10.35 0.38 2.55e-23 Childhood ear infection; BRCA cis rs6688613 0.694 rs12062326 chr1:166820186 G/A ch.1.3259774R chr1:166827647 TADA1 0.42 8.62 0.32 5.39e-17 Refractive astigmatism; BRCA cis rs13064411 0.518 rs1471883 chr3:113211828 C/T cg18753928 chr3:113234510 CCDC52 -0.4 -9.15 -0.34 7.81e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9463078 0.838 rs9357470 chr6:45065613 C/T cg25276700 chr6:44698697 NA -0.36 -8.19 -0.31 1.45e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6121246 0.559 rs6119650 chr20:30258480 C/A cg21427119 chr20:30132790 HM13 -0.37 -8.4 -0.32 2.96e-16 Mean corpuscular hemoglobin; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.92 -18.43 -0.59 3.59e-61 Alzheimer's disease; BRCA cis rs9649465 1.000 rs7805759 chr7:123318696 C/A cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00166722 chr3:10149974 C3orf24 0.56 11.54 0.42 4.1e-28 Alzheimer's disease; BRCA cis rs11229555 0.645 rs12285111 chr11:58208385 T/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11644478 chr21:40555479 PSMG1 0.83 19.13 0.6 7.5e-65 Cognitive function; BRCA cis rs2836974 0.897 rs2026265 chr21:40595517 G/A cg11890956 chr21:40555474 PSMG1 1.06 30.49 0.77 1.02e-126 Cognitive function; BRCA cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg02733842 chr7:1102375 C7orf50 -0.64 -12.06 -0.43 2.55e-30 Bronchopulmonary dysplasia; BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg27170947 chr2:26402098 FAM59B -0.98 -17.45 -0.57 4.66e-56 Gut microbiome composition (summer); BRCA cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg12310025 chr6:25882481 NA 0.53 11.63 0.42 1.72e-28 Intelligence (multi-trait analysis); BRCA cis rs6977660 0.714 rs6943204 chr7:19818671 A/G cg07541023 chr7:19748670 TWISTNB 0.47 8.63 0.32 4.92e-17 Thyroid stimulating hormone; BRCA cis rs4363385 0.747 rs1415961 chr1:152973464 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.06 -0.34 1.61e-18 Inflammatory skin disease; BRCA trans rs11098499 1.000 rs13435802 chr4:120177960 A/T cg25214090 chr10:38739885 LOC399744 -0.48 -10.46 -0.38 9.21e-24 Corneal astigmatism; BRCA cis rs12479064 0.671 rs4851207 chr2:100105775 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.49 -9.57 -0.35 2.21e-20 Chronic sinus infection; BRCA cis rs7772486 0.875 rs6914813 chr6:146397798 A/G cg23711669 chr6:146136114 FBXO30 0.75 17.36 0.57 1.37e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs6964833 1.000 rs34324835 chr7:74132305 T/A cg07504079 chr7:72649617 NCF1B -0.5 -9.82 -0.36 2.82e-21 Menarche (age at onset); BRCA cis rs7618915 0.547 rs2118540 chr3:52629386 T/C cg10802521 chr3:52805072 NEK4 -0.31 -7.91 -0.3 1.1e-14 Bipolar disorder; BRCA cis rs7766436 0.885 rs13220769 chr6:22596464 T/A cg13666174 chr6:22585274 NA -0.49 -11.46 -0.41 9.02e-28 Coronary artery disease; BRCA cis rs11105298 0.891 rs3741898 chr12:89933763 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.54 -0.35 2.85e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg17330251 chr7:94953956 PON1 -0.4 -8.25 -0.31 9.27e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4689388 0.926 rs10937720 chr4:6295451 A/G cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs11039798 0.920 rs11039940 chr11:48716316 C/T cg15704280 chr7:45808275 SEPT13 0.59 8.8 0.33 1.26e-17 Axial length; BRCA cis rs4074536 0.585 rs10923447 chr1:116323567 C/A cg21648376 chr1:116311395 CASQ2 -0.53 -8.81 -0.33 1.22e-17 QRS duration; BRCA cis rs1997103 1.000 rs9642578 chr7:55400320 A/G cg17469321 chr7:55412551 NA 0.51 9.78 0.36 3.77e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs67311347 0.605 rs1880762 chr3:40283215 A/G cg09455208 chr3:40491958 NA 0.34 7.91 0.3 1.11e-14 Renal cell carcinoma; BRCA cis rs1163251 0.902 rs639216 chr1:120217414 C/T cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg16586182 chr3:47516702 SCAP 0.49 10.86 0.39 2.43e-25 Colorectal cancer; BRCA cis rs10216189 0.967 rs4724700 chr7:5526789 A/G cg05318486 chr7:5553423 FBXL18 -0.36 -8.28 -0.31 7.13e-16 Relative hand skill in reading disability; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg03923535 chr7:1197113 ZFAND2A 0.5 11.01 0.4 5.92e-26 Longevity;Endometriosis; BRCA cis rs4930103 1.000 rs4929983 chr11:2024579 C/T cg06197492 chr11:2016605 H19 0.41 8.85 0.33 8.37e-18 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs6089584 0.888 rs6061979 chr20:60617141 C/G cg06108461 chr20:60628389 TAF4 -0.99 -22.28 -0.66 7.76e-82 Body mass index; BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg13047869 chr3:10149882 C3orf24 0.55 10.3 0.38 4.02e-23 Alzheimer's disease; BRCA cis rs1003719 0.788 rs1155785 chr21:38447939 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.26e-40 Eye color traits; BRCA cis rs1468333 1.000 rs7735635 chr5:137508336 G/A cg27119451 chr5:137514611 BRD8;KIF20A -0.45 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs6840360 0.593 rs10016160 chr4:152693998 A/G cg22705602 chr4:152727874 NA -0.38 -10.46 -0.38 9.24e-24 Intelligence (multi-trait analysis); BRCA cis rs2019216 0.521 rs6565386 chr17:21901755 A/G cg14492302 chr17:21911362 FLJ36000 -0.24 -7.83 -0.3 2.09e-14 Pelvic organ prolapse; BRCA cis rs2836950 0.501 rs4818018 chr21:40694072 C/T cg17971929 chr21:40555470 PSMG1 -0.48 -10.5 -0.38 6.57e-24 Menarche (age at onset); BRCA cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg06713675 chr4:122721982 EXOSC9 -0.5 -11.9 -0.43 1.28e-29 Type 2 diabetes; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg23708337 chr7:1209742 NA 0.64 8.93 0.33 4.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg22764044 chr5:178986830 RUFY1 0.46 12.38 0.44 1.03e-31 Lung cancer; BRCA cis rs67460515 0.859 rs7610800 chr3:161002582 C/T cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Parkinson's disease; BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg05457628 chr5:178986728 RUFY1 0.5 11.84 0.42 2.31e-29 Lung cancer; BRCA cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg06784218 chr1:46089804 CCDC17 0.51 12.25 0.44 3.85e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17818399 0.501 rs13413254 chr2:46802934 A/T cg02822958 chr2:46747628 ATP6V1E2 0.46 9.44 0.35 6.83e-20 Height; BRCA cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg11764359 chr7:65958608 NA -0.61 -13.07 -0.46 8.94e-35 Aortic root size; BRCA cis rs586533 0.881 rs674682 chr11:99506883 A/C cg22878054 chr11:99397252 CNTN5 -0.31 -7.82 -0.3 2.27e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2243480 1.000 rs34192067 chr7:65887657 C/A cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs617791 0.678 rs551659 chr11:65749645 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.63 13.98 0.48 6.28e-39 Breast cancer; BRCA cis rs6088580 0.561 rs3761147 chr20:32996689 G/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.68 -0.42 1.04e-28 Glomerular filtration rate (creatinine); BRCA cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg08508325 chr11:3079039 CARS 0.4 14.06 0.49 2.57e-39 Longevity; BRCA cis rs7666738 0.830 rs7678557 chr4:99057329 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.28e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs11583043 1.000 rs11583043 chr1:101466054 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.39 7.82 0.3 2.23e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs881375 1.000 rs10117059 chr9:123653477 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 8.69 0.32 3.14e-17 Rheumatoid arthritis; BRCA cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg00531865 chr16:30841666 NA -0.38 -9.11 -0.34 1.02e-18 Dementia with Lewy bodies; BRCA cis rs8177253 0.509 rs6762415 chr3:133478557 T/G cg01448562 chr3:133502909 NA -0.36 -8.29 -0.31 6.66e-16 Iron status biomarkers; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg08888203 chr3:10149979 C3orf24 0.59 12.75 0.45 2.55e-33 Alzheimer's disease; BRCA cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.05 -0.34 1.64e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.05 16.15 0.54 1.81e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.964 rs778723 chr7:65829497 T/C cg18876405 chr7:65276391 NA 0.55 13.31 0.47 7.72e-36 Aortic root size; BRCA cis rs7582180 0.614 rs10193204 chr2:101004540 A/G cg14675211 chr2:100938903 LONRF2 -0.42 -9.65 -0.36 1.2e-20 Intelligence (multi-trait analysis); BRCA cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.13 0.4 2.01e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg02503808 chr4:7069936 GRPEL1 -0.82 -15.54 -0.52 2.08e-46 Monocyte percentage of white cells; BRCA cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg10495392 chr1:46806563 NSUN4 0.43 8.01 0.3 5.64e-15 Menopause (age at onset); BRCA trans rs7824557 0.603 rs2249804 chr8:11215617 C/G cg06636001 chr8:8085503 FLJ10661 0.51 11.37 0.41 2.05e-27 Retinal vascular caliber; BRCA cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg18755752 chr8:142205143 DENND3 -0.46 -11.15 -0.4 1.66e-26 Immature fraction of reticulocytes; BRCA cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg08807101 chr21:30365312 RNF160 -0.57 -13.87 -0.48 1.98e-38 Dental caries; BRCA cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg15556689 chr8:8085844 FLJ10661 0.38 10.23 0.38 7.45e-23 Neuroticism; BRCA cis rs67311347 1.000 rs9822909 chr3:40457084 G/T cg01475735 chr3:40494733 NA -0.45 -8.0 -0.3 5.76e-15 Renal cell carcinoma; BRCA cis rs4803468 1.000 rs11880539 chr19:41918949 A/C cg09537434 chr19:41945824 ATP5SL 1.01 24.62 0.7 1.24e-94 Height; BRCA cis rs1401999 0.690 rs6768149 chr3:183636195 T/C cg01324343 chr3:183735012 ABCC5 0.65 15.21 0.52 8.52e-45 Anterior chamber depth; BRCA cis rs11888559 0.511 rs1351826 chr2:203850508 G/A cg24605529 chr2:203879461 NBEAL1 0.45 8.43 0.32 2.37e-16 Height; BRCA cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg24642439 chr20:33292090 TP53INP2 0.52 11.44 0.41 1.06e-27 Glomerular filtration rate (creatinine); BRCA cis rs975210 0.556 rs2291986 chr15:70368432 C/T cg01666796 chr15:70364327 TLE3 0.41 7.86 0.3 1.67e-14 Height;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs875971 0.638 rs35986979 chr7:66088990 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.55 -0.32 9.03e-17 Aortic root size; BRCA trans rs11098499 0.954 rs6838814 chr4:120392443 G/A cg25517755 chr10:38738941 LOC399744 -0.37 -7.82 -0.3 2.22e-14 Corneal astigmatism; BRCA cis rs36051895 0.632 rs10974969 chr9:5125336 G/A cg02405213 chr9:5042618 JAK2 -0.5 -9.01 -0.34 2.4e-18 Pediatric autoimmune diseases; BRCA cis rs72781680 0.716 rs17045975 chr2:24099611 A/T cg08917208 chr2:24149416 ATAD2B -0.6 -10.41 -0.38 1.49e-23 Lymphocyte counts; BRCA cis rs16867321 0.614 rs10204086 chr2:181449668 G/T cg23363182 chr2:181467187 NA -0.48 -10.62 -0.39 2.17e-24 Obesity; BRCA cis rs881375 0.715 rs10985073 chr9:123643855 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.47 9.75 0.36 5.02e-21 Rheumatoid arthritis; BRCA trans rs9291683 0.588 rs13121211 chr4:9999539 A/G cg26043149 chr18:55253948 FECH 0.4 8.88 0.33 6.73e-18 Bone mineral density; BRCA cis rs7914558 0.966 rs10450373 chr10:104728616 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.71 0.39 1.02e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg19010396 chr19:19431384 KIAA0892;SF4 -0.45 -8.95 -0.33 3.78e-18 Tonsillectomy; BRCA cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg06618935 chr21:46677482 NA -0.36 -7.98 -0.3 6.96e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9467773 0.626 rs6936006 chr6:26350565 A/G cg09904177 chr6:26538194 HMGN4 -0.31 -8.36 -0.31 3.94e-16 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.827 rs9295680 chr6:25944103 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 10.2 0.37 1.01e-22 Height; BRCA cis rs17345786 1.000 rs17345528 chr3:101294830 A/C cg11279151 chr3:101281821 RG9MTD1 0.49 10.01 0.37 5.26e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs757110 0.866 rs5215 chr11:17408630 C/T cg15432903 chr11:17409602 KCNJ11 0.79 17.69 0.57 2.84e-57 Type 2 diabetes; BRCA cis rs7666738 0.830 rs1426667 chr4:98949772 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.87 0.56 4.31e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg06784218 chr1:46089804 CCDC17 -0.43 -10.13 -0.37 1.82e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7412746 0.658 rs72704682 chr1:150897677 A/T cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.26e-14 Melanoma; BRCA cis rs477895 0.713 rs11600867 chr11:63972052 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 12.68 0.45 5.16e-33 Mean platelet volume; BRCA cis rs9788682 0.747 rs2656071 chr15:78745343 A/T cg24631222 chr15:78858424 CHRNA5 -0.51 -10.08 -0.37 2.86e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA trans rs11098499 0.789 rs1980024 chr4:120253047 C/T cg25214090 chr10:38739885 LOC399744 0.45 10.28 0.38 4.83e-23 Corneal astigmatism; BRCA cis rs713587 0.563 rs7605335 chr2:25109317 G/A cg01884057 chr2:25150051 NA 0.29 7.83 0.3 2.1e-14 Body mass index in non-asthmatics; BRCA cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.6e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.791 rs34152299 chr4:98929862 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs3749237 1.000 rs11710675 chr3:49751900 C/A cg07636037 chr3:49044803 WDR6 0.39 8.02 0.3 5.04e-15 Resting heart rate; BRCA cis rs2153535 0.580 rs7453115 chr6:8447261 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.55e-18 Motion sickness; BRCA cis rs1059312 0.545 rs7312683 chr12:129280105 T/C cg09035930 chr12:129282057 SLC15A4 0.47 12.33 0.44 1.69e-31 Systemic lupus erythematosus; BRCA cis rs12545109 0.879 rs893234 chr8:57363885 G/A cg09654669 chr8:57350985 NA -0.45 -8.57 -0.32 7.87e-17 Obesity-related traits; BRCA cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.9e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6138458 1.000 rs11906373 chr20:24938832 A/G cg26195577 chr20:24973756 C20orf3 1.02 26.56 0.72 2.74e-105 Blood protein levels; BRCA cis rs1863824 0.625 rs10887599 chr10:88168780 G/A cg07322936 chr10:88137208 NA -0.45 -8.89 -0.33 6.16e-18 Schizophrenia; BRCA cis rs36051895 0.632 rs7022901 chr9:5177680 C/G cg02405213 chr9:5042618 JAK2 -0.46 -8.77 -0.33 1.66e-17 Pediatric autoimmune diseases; BRCA cis rs4629710 0.545 rs11154621 chr6:131547341 A/G cg12606694 chr6:131520996 AKAP7 0.43 9.25 0.34 3.42e-19 Multiple myeloma (IgH translocation); BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg04944784 chr2:26401820 FAM59B -0.74 -12.06 -0.43 2.62e-30 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg08470875 chr2:26401718 FAM59B -0.77 -12.04 -0.43 2.96e-30 Gut microbiome composition (summer); BRCA cis rs758324 0.947 rs1875177 chr5:131202625 T/C cg06307176 chr5:131281290 NA 0.53 10.18 0.37 1.15e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg13319975 chr6:146136371 FBXO30 0.41 9.25 0.34 3.38e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg27129171 chr3:47204927 SETD2 0.72 17.72 0.57 1.95e-57 Colorectal cancer; BRCA cis rs7959452 0.535 rs2305641 chr12:69646914 C/T cg20891283 chr12:69753455 YEATS4 0.48 12.49 0.44 3.43e-32 Blood protein levels; BRCA cis rs3087591 1.000 rs2854332 chr17:29712378 A/T cg24425628 chr17:29625626 OMG;NF1 -0.44 -8.86 -0.33 8.16e-18 Hip circumference; BRCA cis rs56104184 0.775 rs73061694 chr19:49399978 T/C cg15549821 chr19:49342101 PLEKHA4 -0.67 -9.72 -0.36 6.19e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7809950 0.954 rs2520243 chr7:107136973 T/C cg23024343 chr7:107201750 COG5 -0.4 -9.17 -0.34 6.53e-19 Coronary artery disease; BRCA cis rs9325144 0.513 rs7977596 chr12:38649067 C/A cg13010199 chr12:38710504 ALG10B -0.39 -8.83 -0.33 1.04e-17 Morning vs. evening chronotype; BRCA cis rs3096299 0.967 rs2965827 chr16:89457350 A/C cg00750074 chr16:89608354 SPG7 0.33 8.97 0.33 3.2e-18 Multiple myeloma (IgH translocation); BRCA cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg22903657 chr4:1355424 KIAA1530 -0.36 -8.09 -0.3 2.97e-15 Obesity-related traits; BRCA cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg24531977 chr5:56204891 C5orf35 -0.81 -16.77 -0.55 1.38e-52 Initial pursuit acceleration; BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26314531 chr2:26401878 FAM59B 0.75 10.54 0.38 4.46e-24 Gut microbiome composition (summer); BRCA cis rs56104184 0.775 rs73061695 chr19:49399988 T/C cg21252483 chr19:49399788 TULP2 -0.51 -10.86 -0.39 2.46e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg19274703 chr22:41806451 NA -0.34 -7.88 -0.3 1.44e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.09 0.4 2.92e-26 Bipolar disorder; BRCA cis rs929354 1.000 rs1182413 chr7:157058557 G/A cg17757837 chr7:157058334 UBE3C -0.72 -17.81 -0.58 6.54e-58 Body mass index; BRCA cis rs13315871 1.000 rs11717423 chr3:58330177 C/G cg20936604 chr3:58311152 NA -0.62 -7.99 -0.3 6.31e-15 Cholesterol, total; BRCA cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2842992 0.789 rs2277072 chr6:160182845 A/G cg11366901 chr6:160182831 ACAT2 0.85 16.58 0.55 1.28e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs16854884 0.657 rs6440210 chr3:143705763 A/G cg06585982 chr3:143692056 C3orf58 0.42 8.8 0.33 1.31e-17 Economic and political preferences (feminism/equality); BRCA cis rs2120243 0.874 rs1840680 chr3:157156029 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.44 9.88 0.36 1.56e-21 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg27478167 chr7:817139 HEATR2 -0.54 -10.91 -0.4 1.6e-25 Cerebrospinal P-tau181p levels; BRCA trans rs9944715 0.954 rs1808946 chr18:43854860 A/G cg01718231 chr17:29326311 RNF135 -0.44 -8.61 -0.32 5.89e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs2835872 0.758 rs1787395 chr21:39036478 A/C cg06728970 chr21:39037746 KCNJ6 0.45 12.83 0.45 1.14e-33 Electroencephalographic traits in alcoholism; BRCA cis rs6089584 0.526 rs6061965 chr20:60607858 A/C cg06108461 chr20:60628389 TAF4 -0.68 -14.14 -0.49 1.12e-39 Body mass index; BRCA cis rs7617773 0.780 rs71323395 chr3:48374077 G/A cg11946769 chr3:48343235 NME6 0.67 13.43 0.47 2.05e-36 Coronary artery disease; BRCA trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg26384229 chr12:38710491 ALG10B 0.74 16.62 0.55 8.14e-52 Morning vs. evening chronotype; BRCA cis rs6087990 0.735 rs2424906 chr20:31359109 A/G cg13636640 chr20:31349939 DNMT3B 0.65 19.13 0.6 8.13e-65 Ulcerative colitis; BRCA cis rs17270561 0.609 rs1892245 chr6:25764833 G/T cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.35 -0.35 1.41e-19 Total body bone mineral density; BRCA cis rs3916 0.955 rs35525135 chr12:121140064 T/C cg21892295 chr12:121157589 UNC119B -0.38 -9.77 -0.36 4.08e-21 Urinary metabolites (H-NMR features); BRCA cis rs6582630 0.502 rs11181214 chr12:38298313 C/A cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.66e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs17023223 0.537 rs55836852 chr1:119725401 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs2549794 0.537 rs34755 chr5:96151760 A/C cg16492584 chr5:96139282 ERAP1 0.32 8.58 0.32 7.14e-17 Crohn's disease; BRCA cis rs4363385 0.818 rs12029168 chr1:152987993 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.3 -0.31 6.23e-16 Inflammatory skin disease; BRCA cis rs847851 0.612 rs7768189 chr6:34742450 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.15e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg04166393 chr7:2884313 GNA12 0.47 8.99 0.33 2.85e-18 Height; BRCA trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21582582 chr3:182698605 DCUN1D1 0.37 9.86 0.36 1.95e-21 Intelligence (multi-trait analysis); BRCA cis rs7301826 0.651 rs10734981 chr12:131297895 C/G cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 3e-37 Plasma plasminogen activator levels; BRCA cis rs208520 0.526 rs7775830 chr6:66755249 A/G cg07460842 chr6:66804631 NA 1.04 29.65 0.76 3.53e-122 Exhaled nitric oxide output; BRCA cis rs6831352 0.918 rs29001224 chr4:100047373 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7584330 0.666 rs937386 chr2:238364039 C/T cg14458575 chr2:238380390 NA 0.74 16.51 0.55 2.84e-51 Prostate cancer; BRCA cis rs7824557 0.815 rs2572430 chr8:11105304 G/T cg21775007 chr8:11205619 TDH 0.39 8.41 0.32 2.65e-16 Retinal vascular caliber; BRCA cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg01689657 chr7:91764605 CYP51A1 0.21 7.87 0.3 1.48e-14 Breast cancer; BRCA cis rs1801251 1.000 rs3816334 chr2:233708806 A/G cg25237894 chr2:233734115 C2orf82 -0.41 -11.81 -0.42 3.12e-29 Coronary artery disease; BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.83 -13.91 -0.48 1.33e-38 Platelet count; BRCA cis rs7617773 0.784 rs11715799 chr3:48255220 A/G cg11946769 chr3:48343235 NME6 0.68 13.8 0.48 4.34e-38 Coronary artery disease; BRCA trans rs57221529 0.766 rs72703065 chr5:588123 C/A cg11887960 chr12:57824829 NA 0.53 8.26 0.31 8.2e-16 Lung disease severity in cystic fibrosis; BRCA cis rs9790314 0.613 rs2121718 chr3:160603511 C/T cg03342759 chr3:160939853 NMD3 0.43 8.31 0.31 5.94e-16 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs1999334 chr21:46670457 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.53 11.46 0.41 9.13e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11088226 1.000 rs11701091 chr21:33920244 T/A cg09050820 chr6:167586206 TCP10L2 0.49 8.05 0.3 4.01e-15 Gastritis; BRCA cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.28 0.49 2.26e-40 Motion sickness; BRCA cis rs765787 0.530 rs1706764 chr15:45524256 T/A cg15395560 chr15:45543142 SLC28A2 0.29 8.27 0.31 7.69e-16 Uric acid levels; BRCA cis rs2197308 0.606 rs2218397 chr12:38278307 C/T cg26384229 chr12:38710491 ALG10B -0.41 -9.8 -0.36 3.31e-21 Morning vs. evening chronotype; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.38e-19 Total body bone mineral density; BRCA trans rs62103177 0.564 rs7228971 chr18:77738025 C/T cg05926928 chr17:57297772 GDPD1 -0.85 -12.34 -0.44 1.65e-31 Opioid sensitivity; BRCA cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg08807892 chr2:162101083 NA 0.72 16.49 0.55 3.72e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg22349387 chr12:9600060 DDX12 -0.38 -8.84 -0.33 9.44e-18 Breast size; BRCA cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg08085267 chr17:45401833 C17orf57 0.59 12.23 0.44 4.69e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs921968 0.565 rs6436084 chr2:219639782 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.93 -0.4 1.27e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs4853036 0.904 rs7578366 chr2:70135695 C/T cg02498382 chr2:70120550 SNRNP27 -0.52 -10.26 -0.38 6.01e-23 Colorectal or endometrial cancer; BRCA cis rs9427116 0.502 rs7531982 chr1:154596122 A/T cg17218026 chr1:154582156 ADAR 0.28 8.44 0.32 2.14e-16 Blood protein levels; BRCA cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.63 0.32 4.69e-17 Glomerular filtration rate (creatinine); BRCA cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg24690094 chr11:67383802 NA -0.54 -11.47 -0.41 7.96e-28 Mean corpuscular volume; BRCA cis rs6582630 0.519 rs8186992 chr12:38325848 C/T cg13010199 chr12:38710504 ALG10B 0.45 9.32 0.35 1.92e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg00152838 chr16:24741724 TNRC6A -0.36 -7.95 -0.3 8.47e-15 Intelligence (multi-trait analysis); BRCA cis rs11971779 0.680 rs6949599 chr7:139054188 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg21782813 chr7:2030301 MAD1L1 0.39 10.39 0.38 1.73e-23 Bipolar disorder and schizophrenia; BRCA cis rs4919694 0.572 rs12262258 chr10:104900272 G/A cg04362960 chr10:104952993 NT5C2 0.72 12.66 0.45 6.05e-33 Arsenic metabolism; BRCA cis rs3741404 0.574 rs616563 chr11:63877501 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.43 10.06 0.37 3.29e-22 Platelet count; BRCA cis rs7945705 0.738 rs11042067 chr11:8815453 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -10.69 -0.39 1.14e-24 Hemoglobin concentration; BRCA cis rs9914988 0.887 rs12948575 chr17:27130520 G/A cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg18904891 chr8:8559673 CLDN23 0.59 11.51 0.41 5.28e-28 Obesity-related traits; BRCA cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.37 0.31 3.58e-16 Cardiac Troponin-T levels; BRCA cis rs561341 0.943 rs508566 chr17:30289861 G/C cg00745463 chr17:30367425 LRRC37B -0.53 -8.75 -0.33 1.95e-17 Hip circumference adjusted for BMI; BRCA cis rs8114671 0.869 rs2038503 chr20:33675900 G/A cg24642439 chr20:33292090 TP53INP2 -0.43 -8.65 -0.32 4.3e-17 Height; BRCA cis rs7666738 0.830 rs1813251 chr4:98921170 A/G cg05340658 chr4:99064831 C4orf37 0.65 15.96 0.53 1.74e-48 Colonoscopy-negative controls vs population controls; BRCA cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg05294307 chr14:35346193 BAZ1A -0.58 -10.3 -0.38 3.98e-23 Psoriasis; BRCA cis rs6460942 0.545 rs17448114 chr7:12524458 G/C cg06484146 chr7:12443880 VWDE -0.6 -7.85 -0.3 1.8e-14 Coronary artery disease; BRCA cis rs12210905 0.688 rs12215386 chr6:27406877 G/T cg08851530 chr6:28072375 NA 0.81 7.89 0.3 1.3e-14 Hip circumference adjusted for BMI; BRCA cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg02297831 chr4:17616191 MED28 0.4 8.62 0.32 5.2e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3771570 1.000 rs73018141 chr2:242221570 G/A cg21155796 chr2:242212141 HDLBP 0.62 9.72 0.36 6.59e-21 Prostate cancer; BRCA cis rs10504229 0.906 rs66480865 chr8:58187100 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs7959452 0.535 rs11615712 chr12:69619736 A/T cg14784868 chr12:69753453 YEATS4 -0.43 -10.98 -0.4 8.12e-26 Blood protein levels; BRCA cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 14.29 0.49 2.14e-40 Hip circumference adjusted for BMI; BRCA trans rs148734725 1 rs148734725 chr3:49406708 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.24 -0.34 3.75e-19 Educational attainment (college completion); BRCA cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg25358565 chr5:93447407 FAM172A 1.2 18.62 0.59 3.58e-62 Diabetic retinopathy; BRCA cis rs2880765 0.835 rs4340287 chr15:86043737 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.36e-17 Coronary artery disease; BRCA trans rs79976124 0.800 rs6918860 chr6:66637741 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.96 0.4 9.84e-26 Type 2 diabetes; BRCA cis rs1580019 0.961 rs6949851 chr7:32493807 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.79 17.47 0.57 3.69e-56 Cognitive ability; BRCA cis rs9816226 1.000 rs73052033 chr3:185828465 T/C cg00760338 chr3:185826511 ETV5 -0.53 -8.2 -0.31 1.32e-15 Obesity;Body mass index; BRCA cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg22875332 chr1:76189707 ACADM 0.68 14.41 0.5 5.9e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11098499 0.820 rs28578366 chr4:120536905 A/G cg09307838 chr4:120376055 NA -0.67 -13.63 -0.47 2.7e-37 Corneal astigmatism; BRCA cis rs6750795 0.746 rs1667301 chr2:232423717 C/T cg19187155 chr2:232395269 NMUR1 0.78 19.94 0.62 3.73e-69 Height; BRCA cis rs854572 0.600 rs705382 chr7:94955221 C/G cg05342682 chr7:94953680 PON1 -0.34 -8.35 -0.31 4.34e-16 Paraoxonase activity; BRCA trans rs35110281 0.681 rs162343 chr21:44957072 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 7.99 0.3 6.55e-15 Mean corpuscular volume; BRCA cis rs7264396 0.635 rs6088971 chr20:34535373 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -15.08 -0.51 3.49e-44 Total cholesterol levels; BRCA cis rs7819412 0.522 rs10088853 chr8:10987967 G/A cg21775007 chr8:11205619 TDH -0.44 -8.72 -0.33 2.42e-17 Triglycerides; BRCA cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg18132916 chr6:79620363 NA -0.46 -10.43 -0.38 1.25e-23 Intelligence (multi-trait analysis); BRCA cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.46 -8.97 -0.33 3.21e-18 Chronic sinus infection; BRCA cis rs2742234 0.955 rs2075910 chr10:43614230 G/A cg15436174 chr10:43711423 RASGEF1A -0.43 -9.14 -0.34 7.94e-19 Hirschsprung disease; BRCA cis rs2742417 0.603 rs2673055 chr3:45772772 G/A cg04837898 chr3:45731254 SACM1L -0.38 -7.82 -0.3 2.24e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg15242686 chr22:24348715 GSTTP1 0.5 12.83 0.45 1.1e-33 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6840360 0.571 rs2406976 chr4:152541056 G/C cg22705602 chr4:152727874 NA -0.32 -8.29 -0.31 6.81e-16 Intelligence (multi-trait analysis); BRCA cis rs11785693 0.862 rs17435612 chr8:4987896 C/T cg26367366 chr8:4980734 NA -0.6 -10.98 -0.4 7.83e-26 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs919433 0.680 rs2605039 chr2:198362851 C/A cg00792783 chr2:198669748 PLCL1 0.4 8.9 0.33 5.81e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10870270 1.000 rs7098014 chr10:133775029 G/A cg17892150 chr10:133769511 PPP2R2D -0.71 -15.36 -0.52 1.56e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs8073060 0.586 rs225250 chr17:33941963 A/G cg19694781 chr19:47549865 TMEM160 -1.04 -21.68 -0.65 1.59e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs6088580 0.609 rs2378205 chr20:33110803 C/G cg24642439 chr20:33292090 TP53INP2 0.53 11.6 0.42 2.23e-28 Glomerular filtration rate (creatinine); BRCA trans rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 1.98e-14 Endometrial cancer; BRCA cis rs8114671 0.562 rs6088647 chr20:33505997 T/C cg07148914 chr20:33460835 GGT7 0.47 10.01 0.37 5.42e-22 Height; BRCA trans rs7618501 1.000 rs3749240 chr3:49750188 T/A cg21659725 chr3:3221576 CRBN -0.71 -21.61 -0.65 3.66e-78 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg21573476 chr21:45109991 RRP1B 0.35 9.24 0.34 3.61e-19 Mean corpuscular volume; BRCA cis rs41271473 0.526 rs10916339 chr1:228716894 C/T cg10167378 chr1:228756711 NA 0.65 10.15 0.37 1.47e-22 Chronic lymphocytic leukemia; BRCA cis rs4722166 0.532 rs6963866 chr7:22757341 C/T cg05472934 chr7:22766657 IL6 0.41 10.1 0.37 2.42e-22 Lung cancer; BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07092213 chr7:1199455 ZFAND2A -0.41 -8.12 -0.31 2.48e-15 Longevity;Endometriosis; BRCA cis rs17685 0.672 rs10952841 chr7:75778626 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs939658 0.805 rs11638004 chr15:79425765 A/C cg17916960 chr15:79447300 NA -0.46 -11.42 -0.41 1.29e-27 Refractive error; BRCA cis rs68170813 0.559 rs79026644 chr7:107031803 A/G cg02696742 chr7:106810147 HBP1 -0.54 -8.78 -0.33 1.49e-17 Coronary artery disease; BRCA cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.5 -0.32 1.38e-16 Aortic root size; BRCA cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.59 10.63 0.39 2.15e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13190036 0.901 rs28715668 chr5:176699268 T/C cg06733329 chr5:176740039 MXD3 -0.47 -8.46 -0.32 1.83e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs1348850 0.567 rs880897 chr2:178532503 C/T cg22681709 chr2:178499509 PDE11A -0.41 -8.86 -0.33 7.65e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.05 -0.34 1.66e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10197940 0.510 rs7557092 chr2:152423459 T/A cg06191203 chr2:152266755 RIF1 -0.4 -10.34 -0.38 2.74e-23 Lung cancer; BRCA cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -8.46 -0.32 1.78e-16 Height; BRCA cis rs7903847 0.642 rs10882923 chr10:99159018 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.43 -0.32 2.23e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs372883 0.648 rs1153291 chr21:30689070 G/T cg24692254 chr21:30365293 RNF160 -0.43 -9.64 -0.36 1.28e-20 Pancreatic cancer; BRCA cis rs3008870 0.755 rs4655660 chr1:67402953 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.13 0.49 1.18e-39 Lymphocyte percentage of white cells; BRCA cis rs17253792 1.000 rs28616134 chr14:56178802 G/A cg01858014 chr14:56050164 KTN1 -0.67 -8.51 -0.32 1.22e-16 Putamen volume; BRCA cis rs6942756 1.000 rs2402945 chr7:128956256 C/A cg02491457 chr7:128862824 NA -0.71 -14.0 -0.48 5.08e-39 White matter hyperintensity burden; BRCA cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03264133 chr6:25882463 NA -0.75 -16.33 -0.54 2.34e-50 Intelligence (multi-trait analysis); BRCA cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg07220782 chr6:26987966 LOC100270746;C6orf41 0.32 10.35 0.38 2.67e-23 Autism spectrum disorder or schizophrenia; BRCA cis rs6121246 0.559 rs6121172 chr20:30296095 A/C cg13852791 chr20:30311386 BCL2L1 0.96 23.38 0.68 7.83e-88 Mean corpuscular hemoglobin; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -14.06 -0.49 2.68e-39 Initial pursuit acceleration; BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.42 0.47 2.29e-36 Platelet count; BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg14004847 chr7:1930337 MAD1L1 -0.49 -9.67 -0.36 9.97e-21 Bipolar disorder and schizophrenia; BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg04518342 chr5:131593106 PDLIM4 0.35 8.85 0.33 8.43e-18 Breast cancer; BRCA cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.66 9.92 0.37 1.18e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10754283 0.901 rs10922683 chr1:90116068 G/A cg21401794 chr1:90099060 LRRC8C 0.51 12.24 0.44 4.28e-31 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1163251 0.902 rs483360 chr1:120200606 C/T cg19096424 chr1:120255104 PHGDH -0.43 -9.58 -0.35 2.18e-20 Blood metabolite levels; BRCA cis rs80130819 0.515 rs1793917 chr12:48384944 A/T cg05342945 chr12:48394962 COL2A1 -0.5 -9.67 -0.36 9.91e-21 Prostate cancer; BRCA cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg09184832 chr6:79620586 NA -0.48 -10.46 -0.38 9.7e-24 Intelligence (multi-trait analysis); BRCA cis rs2637266 0.935 rs2579774 chr10:78402253 T/C cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 11.11 0.4 2.5e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs1493916 0.905 rs7239283 chr18:31395397 G/A cg15819921 chr19:927150 ARID3A -0.52 -10.09 -0.37 2.52e-22 Life satisfaction; BRCA cis rs30380 0.632 rs27640 chr5:96127905 T/C cg16492584 chr5:96139282 ERAP1 -0.46 -11.0 -0.4 7.09e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.39 -0.32 3.1e-16 Total body bone mineral density; BRCA cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.02 -0.37 4.67e-22 Alzheimer's disease (late onset); BRCA cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg08885076 chr2:99613938 TSGA10 -0.61 -13.37 -0.47 3.79e-36 Chronic sinus infection; BRCA cis rs10129255 0.518 rs8009594 chr14:107185733 G/T cg07958169 chr14:107095056 NA -0.39 -8.46 -0.32 1.84e-16 Kawasaki disease; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg00166722 chr3:10149974 C3orf24 0.65 12.85 0.45 9.06e-34 Alzheimer's disease; BRCA cis rs895636 0.848 rs2840037 chr2:45189872 G/A cg16198908 chr2:45192207 NA 0.47 8.84 0.33 9.37e-18 Metabolite levels;Fasting plasma glucose; BRCA cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg24531977 chr5:56204891 C5orf35 -0.72 -16.11 -0.54 2.79e-49 Initial pursuit acceleration; BRCA cis rs2625529 0.526 rs62022789 chr15:72564492 C/T cg16672083 chr15:72433130 SENP8 0.61 14.42 0.5 5.17e-41 Red blood cell count; BRCA cis rs7772486 0.686 rs2072911 chr6:146056801 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -16.78 -0.55 1.24e-52 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.534 rs1817761 chr12:34105719 C/T cg26384229 chr12:38710491 ALG10B 0.68 14.16 0.49 8.91e-40 Morning vs. evening chronotype; BRCA cis rs1595825 0.891 rs78198610 chr2:198522769 T/C cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.91e-15 Ulcerative colitis; BRCA cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs78456975 0.739 rs28913003 chr2:1519620 A/T cg26248373 chr2:1572462 NA -0.52 -10.58 -0.39 3.38e-24 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9309711 0.922 rs13385119 chr2:3484521 G/A cg10845886 chr2:3471009 TTC15 -0.81 -17.78 -0.58 9.5e-58 Neurofibrillary tangles; BRCA trans rs3780486 0.846 rs10758192 chr9:33131651 G/A cg04842962 chr6:43655489 MRPS18A 1.11 39.06 0.84 1.91e-171 IgG glycosylation; BRCA cis rs912057 1.000 rs1294407 chr6:6738103 C/G cg06612196 chr6:6737390 NA 0.45 9.84 0.36 2.28e-21 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg26116260 chr4:7069785 GRPEL1 0.92 23.27 0.68 3.35e-87 Monocyte percentage of white cells; BRCA cis rs936229 1.000 rs4886615 chr15:75131661 A/G cg10253484 chr15:75165896 SCAMP2 -0.54 -10.05 -0.37 3.75e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs3768617 0.510 rs4491025 chr1:183065183 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 18.02 0.58 5.02e-59 Fuchs's corneal dystrophy; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7917772 0.503 rs2031601 chr10:104308064 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.19 0.62 1.73e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2425143 1.000 rs56052651 chr20:34344084 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -9.18 -0.34 5.86e-19 Blood protein levels; BRCA cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg18230493 chr5:56204884 C5orf35 0.61 13.01 0.46 1.73e-34 Initial pursuit acceleration; BRCA cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg21573476 chr21:45109991 RRP1B -0.35 -9.12 -0.34 9.42e-19 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs28522896 chr4:99008243 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.54 0.57 1.68e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2602836 0.830 rs2602874 chr4:100039396 A/T cg12011299 chr4:100065546 ADH4 0.52 15.33 0.52 2.03e-45 HDL cholesterol;HDL cholesterol levels; BRCA cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg24642439 chr20:33292090 TP53INP2 0.72 16.61 0.55 8.91e-52 Coronary artery disease; BRCA cis rs9814567 1.000 rs11706117 chr3:134212526 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.53 -0.61 5.54e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2637266 1.000 rs12260492 chr10:78365242 C/A cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs2749592 0.588 rs2504144 chr10:38383525 C/T cg25427524 chr10:38739819 LOC399744 -0.67 -13.56 -0.47 5.32e-37 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4742903 0.967 rs10820605 chr9:106881402 C/T cg14250997 chr9:106856677 SMC2 0.35 11.22 0.41 8.7e-27 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs75804782 0.641 rs11904390 chr2:239344663 T/A cg18131467 chr2:239335373 ASB1 -0.62 -8.16 -0.31 1.79e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs9880211 0.948 rs1604793 chr3:136181070 G/C cg21827317 chr3:136751795 NA -0.47 -8.36 -0.31 3.78e-16 Body mass index;Height; BRCA cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg13319975 chr6:146136371 FBXO30 0.41 9.33 0.35 1.67e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs10911232 0.507 rs6668980 chr1:183018857 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 16.97 0.56 1.3e-53 Hypertriglyceridemia; BRCA cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg20503657 chr10:835505 NA 0.95 14.77 0.5 1.14e-42 Eosinophil percentage of granulocytes; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg00908189 chr16:619842 PIGQ 0.7 17.69 0.57 2.66e-57 Height; BRCA cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg16423285 chr20:60520624 NA -0.42 -8.06 -0.3 3.74e-15 Body mass index; BRCA cis rs6728642 0.908 rs11901495 chr2:98017804 A/G cg26665480 chr2:98280029 ACTR1B 0.52 8.8 0.33 1.23e-17 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg11890956 chr21:40555474 PSMG1 -0.86 -22.26 -0.66 1.04e-81 Cognitive function; BRCA cis rs17253792 0.822 rs8013831 chr14:56172898 G/A cg01858014 chr14:56050164 KTN1 -0.58 -9.01 -0.34 2.31e-18 Putamen volume; BRCA cis rs244731 1.000 rs244730 chr5:176539212 A/G cg17509989 chr5:176798049 RGS14 -0.73 -12.07 -0.43 2.32e-30 Urate levels in lean individuals; BRCA cis rs6964587 1.000 rs12666179 chr7:91574110 T/C cg17063962 chr7:91808500 NA -0.57 -13.48 -0.47 1.2e-36 Breast cancer; BRCA cis rs9359856 0.564 rs55722352 chr6:90365853 C/T cg13799429 chr6:90582589 CASP8AP2 -0.64 -8.54 -0.32 9.91e-17 Bipolar disorder; BRCA cis rs6546537 0.714 rs17036759 chr2:69767029 C/T cg10773587 chr2:69614142 GFPT1 -0.42 -9.28 -0.34 2.69e-19 Serum thyroid-stimulating hormone levels; BRCA trans rs747782 0.528 rs16905753 chr11:48285906 C/T cg15704280 chr7:45808275 SEPT13 0.52 7.94 0.3 9.14e-15 Intraocular pressure; BRCA cis rs3849570 0.961 rs3772896 chr3:81751968 C/T cg07356753 chr3:81810745 GBE1 -0.47 -11.51 -0.41 5.69e-28 Waist circumference;Body mass index; BRCA cis rs9309711 0.961 rs11675119 chr2:3476422 C/A cg10845886 chr2:3471009 TTC15 -0.76 -16.3 -0.54 3.21e-50 Neurofibrillary tangles; BRCA cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg17420585 chr12:42539391 GXYLT1 -0.38 -7.97 -0.3 7.37e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6580649 0.941 rs1968071 chr12:48489357 A/G cg05342945 chr12:48394962 COL2A1 0.4 7.9 0.3 1.26e-14 Lung cancer; BRCA cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg11764359 chr7:65958608 NA -0.62 -13.14 -0.46 4.35e-35 Aortic root size; BRCA cis rs2279817 1.000 rs10888048 chr1:18019742 C/T cg21791023 chr1:18019539 ARHGEF10L 0.55 16.39 0.54 1.17e-50 Neuroticism; BRCA cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg04455712 chr21:45112962 RRP1B 0.38 9.81 0.36 2.99e-21 Mean corpuscular volume; BRCA cis rs6495122 0.501 rs7167261 chr15:75343807 T/C cg13906792 chr15:75199810 C15orf17 0.34 8.04 0.3 4.4e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; BRCA cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg16414030 chr3:133502952 NA -0.47 -11.12 -0.4 2.13e-26 Iron status biomarkers; BRCA cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg25767906 chr1:53392781 SCP2 -0.38 -8.57 -0.32 7.55e-17 Monocyte count; BRCA cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg26597838 chr10:835615 NA 1.03 17.78 0.58 8.92e-58 Eosinophil percentage of granulocytes; BRCA cis rs2415984 0.622 rs61993305 chr14:46950955 C/T cg14871534 chr14:47121158 RPL10L -0.33 -8.17 -0.31 1.68e-15 Number of children ever born; BRCA cis rs2115630 0.967 rs11073702 chr15:85310071 G/A cg12863693 chr15:85201151 NMB -0.33 -8.0 -0.3 6.03e-15 P wave terminal force; BRCA cis rs17095355 0.688 rs1349348 chr10:111794554 T/C cg00817464 chr10:111662876 XPNPEP1 0.38 9.26 0.34 3.12e-19 Biliary atresia; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs4713118 0.662 rs149961 chr6:28015569 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.21e-14 Parkinson's disease; BRCA trans rs61931739 0.534 rs4931772 chr12:34044590 G/A cg26384229 chr12:38710491 ALG10B 0.56 12.16 0.43 9.7e-31 Morning vs. evening chronotype; BRCA cis rs701145 0.585 rs1534386 chr3:153819035 C/G cg17054900 chr3:154042577 DHX36 0.53 9.04 0.34 1.88e-18 Coronary artery disease; BRCA cis rs875971 0.830 rs778711 chr7:65851657 G/A cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs7312933 0.558 rs1796388 chr12:42785987 G/C cg01256987 chr12:42539512 GXYLT1 0.39 7.86 0.3 1.67e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7789940 1.000 rs7789940 chr7:75951230 A/G cg10167463 chr7:75959203 YWHAG -0.45 -8.89 -0.33 6.23e-18 Multiple sclerosis; BRCA cis rs17376456 0.877 rs2290937 chr5:93356515 A/T cg21475434 chr5:93447410 FAM172A 0.62 8.35 0.31 4.16e-16 Diabetic retinopathy; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg18765753 chr7:1198926 ZFAND2A -0.46 -10.63 -0.39 2.04e-24 Longevity;Endometriosis; BRCA cis rs7829975 0.593 rs2921061 chr8:8317615 A/T cg15556689 chr8:8085844 FLJ10661 0.5 13.97 0.48 6.93e-39 Mood instability; BRCA cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg08807101 chr21:30365312 RNF160 -0.54 -12.95 -0.46 3.25e-34 Dental caries; BRCA cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg20503657 chr10:835505 NA 0.99 17.46 0.57 4.23e-56 Eosinophil percentage of granulocytes; BRCA cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg12927641 chr6:109611667 NA -0.41 -10.85 -0.39 2.65e-25 Reticulocyte fraction of red cells; BRCA cis rs523522 0.962 rs9040 chr12:120900274 C/T cg27279351 chr12:120934652 DYNLL1 0.58 13.28 0.47 1.02e-35 High light scatter reticulocyte count; BRCA trans rs7939886 0.920 rs11231794 chr11:55765776 T/C cg15704280 chr7:45808275 SEPT13 0.62 7.92 0.3 1.03e-14 Myopia (pathological); BRCA cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg19748678 chr4:122722346 EXOSC9 0.72 15.5 0.52 3.26e-46 Type 2 diabetes; BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg27170947 chr2:26402098 FAM59B -0.66 -11.32 -0.41 3.36e-27 Gut microbiome composition (summer); BRCA cis rs2882667 0.858 rs7724108 chr5:138410922 A/G cg04439458 chr5:138467593 SIL1 0.45 11.39 0.41 1.76e-27 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg25767906 chr1:53392781 SCP2 -0.43 -9.87 -0.36 1.78e-21 Monocyte count; BRCA cis rs17023223 0.537 rs12081327 chr1:119686358 A/G cg05756136 chr1:119680316 WARS2 -0.41 -7.88 -0.3 1.41e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs11734570 0.581 rs73811716 chr4:38590773 C/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.58 11.39 0.41 1.72e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg04827223 chr11:72435913 ARAP1 -0.59 -15.43 -0.52 6.78e-46 Body mass index; BRCA cis rs911555 0.511 rs8007489 chr14:104054572 A/G cg12935359 chr14:103987150 CKB 0.52 12.67 0.45 5.61e-33 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.505 rs75122014 chr4:120362426 G/C cg09307838 chr4:120376055 NA 0.74 15.84 0.53 6.39e-48 Corneal astigmatism; BRCA cis rs9287719 0.901 rs55861579 chr2:10763340 T/A cg02196655 chr2:10830764 NOL10 -0.3 -7.99 -0.3 6.12e-15 Prostate cancer; BRCA trans rs61931739 0.782 rs451940 chr12:34196005 T/C cg26384229 chr12:38710491 ALG10B 0.43 10.31 0.38 3.53e-23 Morning vs. evening chronotype; BRCA cis rs2624839 0.704 rs12637671 chr3:50224562 G/A cg24110177 chr3:50126178 RBM5 0.47 12.23 0.44 4.5e-31 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26314531 chr2:26401878 FAM59B -0.98 -16.87 -0.56 4.52e-53 Gut microbiome composition (summer); BRCA cis rs7412746 0.611 rs10888395 chr1:150762171 C/T cg15448220 chr1:150897856 SETDB1 0.36 8.04 0.3 4.43e-15 Melanoma; BRCA trans rs2204008 0.522 rs117743143 chr12:38030824 C/T cg06521331 chr12:34319734 NA -0.45 -8.84 -0.33 9.08e-18 Bladder cancer; BRCA cis rs3812831 0.669 rs7327370 chr13:114946858 A/G cg08824895 chr13:115047677 UPF3A 0.49 9.78 0.36 3.93e-21 Schizophrenia; BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg01877450 chr7:97915802 BRI3 -0.39 -8.72 -0.33 2.36e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6089829 0.962 rs3746747 chr20:61667631 T/C cg02544614 chr20:61657117 NA 0.29 7.96 0.3 7.77e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs11083475 0.714 rs1471432 chr19:39260282 G/A cg07905965 chr19:39260460 NA 0.49 11.23 0.41 7.51e-27 Heart rate; BRCA cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg07917127 chr4:99064746 C4orf37 0.44 8.1 0.31 2.86e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10267417 0.535 rs6946403 chr7:19861549 C/T cg05791153 chr7:19748676 TWISTNB 0.48 9.51 0.35 3.77e-20 Night sleep phenotypes; BRCA cis rs7582720 1.000 rs72936309 chr2:204040296 G/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.25 0.44 3.99e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs4728302 0.869 rs10253633 chr7:133590869 A/G cg07491979 chr7:133331646 EXOC4 0.36 7.81 0.3 2.32e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.32 -0.44 1.93e-31 Bipolar disorder; BRCA trans rs11098499 0.909 rs10020034 chr4:120294331 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.05 0.3 3.95e-15 Corneal astigmatism; BRCA cis rs7809950 0.953 rs2237670 chr7:107131485 A/G cg23024343 chr7:107201750 COG5 -0.41 -9.54 -0.35 2.86e-20 Coronary artery disease; BRCA cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs2463822 1.000 rs2513749 chr11:62105391 C/T cg06239285 chr11:62104954 ASRGL1 0.67 11.47 0.41 7.9e-28 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs2842992 0.789 rs9364536 chr6:160225559 G/C cg11366901 chr6:160182831 ACAT2 0.83 15.91 0.53 3.09e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs9399135 0.967 rs6909975 chr6:135315570 C/T cg24558204 chr6:135376177 HBS1L 0.44 11.85 0.42 2.03e-29 Red blood cell count; BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.04 23.0 0.67 8.99e-86 Platelet count; BRCA cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg04317338 chr11:64019027 PLCB3 0.55 9.51 0.35 3.77e-20 Mean platelet volume; BRCA cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg26597838 chr10:835615 NA 1.03 18.35 0.59 1e-60 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg21535247 chr6:8435926 SLC35B3 0.42 9.61 0.36 1.67e-20 Motion sickness; BRCA cis rs62380364 0.626 rs618741 chr5:88064012 C/T cg22951263 chr5:87985283 NA -0.37 -10.32 -0.38 3.37e-23 Intelligence (multi-trait analysis); BRCA cis rs11123610 0.520 rs66557864 chr2:3720812 C/A cg19052272 chr2:3704530 ALLC -0.46 -10.37 -0.38 2.13e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs12618769 0.543 rs4851132 chr2:99042782 T/C cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.71e-15 Bipolar disorder; BRCA cis rs4595586 0.546 rs10876163 chr12:39244915 G/A cg26384229 chr12:38710491 ALG10B 0.66 14.23 0.49 4.08e-40 Morning vs. evening chronotype; BRCA trans rs1962073 0.623 rs7459532 chr8:10261068 C/T cg06636001 chr8:8085503 FLJ10661 -0.38 -7.98 -0.3 6.83e-15 Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab); BRCA cis rs6088590 0.687 rs13044899 chr20:33287078 G/A cg08999081 chr20:33150536 PIGU 0.45 12.08 0.43 2.18e-30 Coronary artery disease; BRCA cis rs6460942 1.000 rs79659770 chr7:12326371 T/C cg06484146 chr7:12443880 VWDE -0.62 -8.57 -0.32 7.55e-17 Coronary artery disease; BRCA cis rs514406 0.505 rs374849 chr1:53185631 G/A cg08859206 chr1:53392774 SCP2 -0.44 -8.7 -0.33 2.75e-17 Monocyte count; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg07308232 chr7:1071921 C7orf50 -0.5 -10.52 -0.38 5.4e-24 Longevity;Endometriosis; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg09256448 chr16:638327 NA 0.3 7.99 0.3 6.54e-15 Height; BRCA cis rs10782582 0.593 rs6673786 chr1:76149637 C/T cg03433033 chr1:76189801 ACADM -0.46 -9.0 -0.34 2.61e-18 Daytime sleep phenotypes; BRCA cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg07917127 chr4:99064746 C4orf37 0.44 8.1 0.31 2.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs965469 1.000 rs6139064 chr20:3277050 G/T cg25506879 chr20:3388711 C20orf194 -0.51 -10.26 -0.38 5.58e-23 IFN-related cytopenia; BRCA cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg11812906 chr14:75593930 NEK9 -0.55 -12.5 -0.44 3.09e-32 Height; BRCA cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg17971929 chr21:40555470 PSMG1 0.75 15.77 0.53 1.46e-47 Cognitive function; BRCA cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg27170947 chr2:26402098 FAM59B 0.97 17.09 0.56 3.41e-54 Gut microbiome composition (summer); BRCA cis rs6763687 0.930 rs4894797 chr3:171783546 G/A cg16233210 chr3:171778391 FNDC3B 0.5 11.67 0.42 1.19e-28 Red cell distribution width; BRCA cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg24531977 chr5:56204891 C5orf35 -0.88 -18.13 -0.58 1.46e-59 Initial pursuit acceleration; BRCA cis rs7786877 0.723 rs10487157 chr7:100214487 C/G cg16850897 chr7:100343110 ZAN -0.58 -11.26 -0.41 5.76e-27 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs35123781 0.696 rs7703195 chr5:139071632 G/A cg10513866 chr5:139070639 NA 0.45 9.79 0.36 3.46e-21 Schizophrenia; BRCA cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -7.89 -0.3 1.36e-14 Extrinsic epigenetic age acceleration; BRCA cis rs7258465 1.000 rs4808134 chr19:18608579 G/A cg01065977 chr19:18549689 ISYNA1 -0.28 -8.29 -0.31 6.59e-16 Breast cancer; BRCA cis rs6743226 0.870 rs12624197 chr2:242254737 G/C cg10021735 chr2:242295487 FARP2 0.37 10.13 0.37 1.79e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs4363385 0.747 rs1415959 chr1:152973690 C/T cg25856811 chr1:152973957 SPRR3 0.34 9.32 0.35 1.9e-19 Inflammatory skin disease; BRCA cis rs897080 0.515 rs1067349 chr2:44670369 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.37 0.35 1.26e-19 Height; BRCA cis rs2839186 0.814 rs12482209 chr21:47664275 C/G cg13012494 chr21:47604986 C21orf56 -0.41 -8.54 -0.32 9.55e-17 Testicular germ cell tumor; BRCA cis rs1801251 1.000 rs10933412 chr2:233707226 G/C cg08000102 chr2:233561755 GIGYF2 -0.64 -14.0 -0.48 5.16e-39 Coronary artery disease; BRCA cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8180040 0.739 rs12488225 chr3:47235107 G/A cg27129171 chr3:47204927 SETD2 0.74 18.94 0.6 8.23e-64 Colorectal cancer; BRCA cis rs4809760 0.669 rs6020069 chr20:48438572 T/C cg17835207 chr20:48524531 SPATA2 0.37 8.26 0.31 8.23e-16 Gut microbiota (beta diversity); BRCA cis rs11711311 1.000 rs2566970 chr3:113462123 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.36 -9.27 -0.34 2.77e-19 IgG glycosylation; BRCA cis rs10193935 0.901 rs6544529 chr2:42510652 A/T cg27598129 chr2:42591480 NA -0.94 -14.78 -0.5 9.39e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs4713118 0.866 rs2179094 chr6:27741825 T/C cg26587870 chr6:27730563 NA -0.41 -8.83 -0.33 9.71e-18 Parkinson's disease; BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg14004847 chr7:1930337 MAD1L1 -0.44 -8.69 -0.33 3.01e-17 Bipolar disorder and schizophrenia; BRCA cis rs6723226 0.708 rs2754513 chr2:32782763 G/A cg02381751 chr2:32503542 YIPF4 0.66 14.13 0.49 1.15e-39 Intelligence (multi-trait analysis); BRCA cis rs12210905 0.688 rs72843191 chr6:27383301 G/C cg08851530 chr6:28072375 NA 0.81 7.97 0.3 7.49e-15 Hip circumference adjusted for BMI; BRCA cis rs6429082 0.714 rs704719 chr1:235667170 G/A cg26050004 chr1:235667680 B3GALNT2 0.56 13.11 0.46 6.21e-35 Adiposity; BRCA cis rs6669008 1.000 rs55912359 chr1:114167099 C/T cg26035817 chr1:114414802 PTPN22 0.35 8.35 0.31 4.17e-16 Bacteremia; BRCA cis rs4076764 0.830 rs10917770 chr1:163442214 G/C cg24596788 chr1:163392923 NA -0.37 -9.83 -0.36 2.52e-21 Motion sickness; BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg04025307 chr7:1156635 C7orf50 0.56 13.0 0.46 1.98e-34 Longevity;Endometriosis; BRCA cis rs7937840 0.501 rs4963459 chr11:61877137 G/A cg01969543 chr11:61895209 INCENP -0.39 -8.59 -0.32 6.79e-17 Breast cancer; BRCA cis rs26868 0.690 rs26835 chr16:2237549 C/T cg25665528 chr16:2260870 C16orf79 -0.33 -8.19 -0.31 1.38e-15 Height; BRCA cis rs2985684 1.000 rs11157696 chr14:50105746 C/G cg04989706 chr14:50066350 PPIL5 0.48 9.33 0.35 1.67e-19 Carotid intima media thickness; BRCA cis rs11828289 0.660 rs17306433 chr11:23223034 C/G cg20040320 chr11:23191996 NA -0.53 -7.81 -0.3 2.41e-14 Cancer; BRCA cis rs853679 0.517 rs1904841 chr6:28108085 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.13 -0.31 2.25e-15 Depression; BRCA cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg20503657 chr10:835505 NA 1.05 18.38 0.59 6.64e-61 Eosinophil percentage of granulocytes; BRCA cis rs739401 0.611 rs572373 chr11:3055361 T/C cg05729581 chr11:3078854 CARS -0.35 -8.65 -0.32 4.15e-17 Longevity; BRCA cis rs34779708 0.966 rs10508816 chr10:35459976 G/A cg03585969 chr10:35415529 CREM 0.45 9.42 0.35 7.93e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg11752832 chr7:134001865 SLC35B4 0.46 11.61 0.42 2.1e-28 Mean platelet volume; BRCA cis rs1468333 1.000 rs4552585 chr5:137533159 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.49 0.32 1.5e-16 Resting heart rate; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.73 16.4 0.54 1.09e-50 Lymphocyte counts; BRCA cis rs8072100 0.967 rs7219303 chr17:45737701 A/G cg25173405 chr17:45401733 C17orf57 0.5 10.43 0.38 1.23e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg13770153 chr20:60521292 NA -0.34 -7.84 -0.3 1.89e-14 Body mass index; BRCA cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.643 rs552882 chr2:219401726 G/A cg02176678 chr2:219576539 TTLL4 0.39 10.54 0.38 4.57e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg01579765 chr21:45077557 HSF2BP -0.44 -11.79 -0.42 3.75e-29 Mean corpuscular volume; BRCA cis rs6461049 0.800 rs3800909 chr7:2159594 C/G cg02951883 chr7:2050386 MAD1L1 -0.45 -10.58 -0.39 3.19e-24 Schizophrenia; BRCA cis rs2235642 0.691 rs2281235 chr16:1603535 T/C cg09065629 chr16:1709722 CRAMP1L 0.37 8.76 0.33 1.73e-17 Coronary artery disease; BRCA cis rs875971 1.000 rs6958271 chr7:65979331 A/C cg11764359 chr7:65958608 NA 0.8 19.21 0.6 3.07e-65 Aortic root size; BRCA cis rs4664304 0.620 rs55664214 chr2:160708059 C/T cg14819504 chr2:160761413 LY75 -0.32 -7.85 -0.3 1.74e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7662987 0.517 rs2034696 chr4:100024322 C/G cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Smoking initiation; BRCA cis rs1048238 0.846 rs945417 chr1:16344625 C/G cg06159980 chr1:16340746 HSPB7 -0.4 -9.03 -0.34 2e-18 Systolic blood pressure; BRCA cis rs2288073 0.965 rs10192600 chr2:24396680 A/G cg26838691 chr2:24397539 C2orf84 -0.53 -9.45 -0.35 6.19e-20 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs8114671 0.967 rs2065978 chr20:33767291 C/T cg07148914 chr20:33460835 GGT7 0.39 8.28 0.31 7.4e-16 Height; BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg27170947 chr2:26402098 FAM59B 0.97 16.89 0.56 3.52e-53 Gut microbiome composition (summer); BRCA cis rs11764590 0.694 rs10276536 chr7:2086960 C/T cg23422044 chr7:1970798 MAD1L1 -0.46 -10.25 -0.38 6.55e-23 Neuroticism; BRCA trans rs61931739 1.000 rs12427279 chr12:34025898 T/G cg26384229 chr12:38710491 ALG10B -0.43 -9.65 -0.36 1.17e-20 Morning vs. evening chronotype; BRCA cis rs2629751 0.512 rs2723845 chr12:104446721 T/C cg14987745 chr12:104360022 TDG -0.48 -9.1 -0.34 1.14e-18 Hepatitis C induced liver fibrosis; BRCA cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4713118 0.621 rs4713133 chr6:28034041 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.1 0.31 2.83e-15 Parkinson's disease; BRCA cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg13114125 chr14:105738426 BRF1 -0.54 -11.46 -0.41 8.79e-28 Mean platelet volume;Platelet distribution width; BRCA cis rs870825 0.860 rs72689277 chr4:185593699 G/A cg04058563 chr4:185651563 MLF1IP 0.84 14.09 0.49 1.87e-39 Blood protein levels; BRCA cis rs7659604 0.676 rs6534323 chr4:122695888 G/A cg06713675 chr4:122721982 EXOSC9 -0.49 -11.74 -0.42 5.79e-29 Type 2 diabetes; BRCA cis rs66569888 0.789 rs1317569 chr2:106735490 C/A cg16099169 chr2:106886729 NA -0.59 -10.55 -0.39 4.11e-24 Facial morphology (factor 23); BRCA cis rs34779708 0.966 rs12775799 chr10:35488264 C/T cg03585969 chr10:35415529 CREM 0.49 10.38 0.38 2.0500000000000001e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.49 0.41 6.46e-28 Bipolar disorder; BRCA cis rs7666738 0.791 rs2865958 chr4:99040732 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.77e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2075371 0.830 rs2077671 chr7:133951204 C/T cg11752832 chr7:134001865 SLC35B4 0.5 12.74 0.45 2.81e-33 Mean platelet volume; BRCA cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.6 0.32 6e-17 Rheumatoid arthritis; BRCA cis rs7246657 0.882 rs59224125 chr19:37963205 T/C cg23950597 chr19:37808831 NA -0.61 -11.49 -0.41 6.73e-28 Coronary artery calcification; BRCA cis rs9462027 0.628 rs2038839 chr6:34777791 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.89 -0.3 1.33e-14 Systemic lupus erythematosus; BRCA cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg15595755 chr5:1867978 NA 0.37 8.76 0.33 1.78e-17 Cardiovascular disease risk factors; BRCA cis rs36051895 0.632 rs62541944 chr9:5159318 G/T cg02405213 chr9:5042618 JAK2 -0.48 -8.85 -0.33 8.36e-18 Pediatric autoimmune diseases; BRCA cis rs9790314 0.628 rs4342141 chr3:160783922 T/C cg03342759 chr3:160939853 NMD3 -0.52 -10.7 -0.39 1.13e-24 Morning vs. evening chronotype; BRCA trans rs11098499 0.954 rs10006706 chr4:120409152 A/G cg25214090 chr10:38739885 LOC399744 0.53 12.06 0.43 2.49e-30 Corneal astigmatism; BRCA trans rs11098499 0.909 rs28668716 chr4:120309875 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.52 0.41 4.81e-28 Corneal astigmatism; BRCA cis rs72634258 0.554 rs12741937 chr1:7897622 A/T cg26816564 chr1:7831052 VAMP3 0.73 13.01 0.46 1.72e-34 Inflammatory bowel disease; BRCA cis rs801193 0.935 rs2659916 chr7:66151352 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.38 0.31 3.26e-16 Aortic root size; BRCA cis rs782590 0.902 rs782595 chr2:55845596 C/G cg18811423 chr2:55921094 PNPT1 0.71 22.36 0.66 3.16e-82 Metabolic syndrome; BRCA trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg15704280 chr7:45808275 SEPT13 -0.46 -8.93 -0.33 4.59e-18 Height; BRCA cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9596863 0.898 rs9316655 chr13:54319640 A/G ch.13.53330881F chr13:54432880 NA 0.45 7.82 0.3 2.23e-14 Epilepsy and lamotrigine-induced maculopapular eruptions; BRCA cis rs7659604 0.539 rs2063165 chr4:122750005 A/G cg06713675 chr4:122721982 EXOSC9 -0.53 -12.46 -0.44 4.65e-32 Type 2 diabetes; BRCA cis rs11051970 0.553 rs325419 chr12:32572460 A/G cg02745156 chr12:32552066 NA 0.23 7.92 0.3 1.05e-14 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs1003719 0.788 rs60447195 chr21:38448600 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.26e-40 Eye color traits; BRCA cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg22535103 chr8:58192502 C8orf71 -0.42 -8.56 -0.32 8.18e-17 Developmental language disorder (linguistic errors); BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.9 -16.87 -0.56 4.43e-53 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg16179182 chr5:140090404 VTRNA1-1 0.46 10.87 0.39 2.32e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.75 0.33 1.9e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.92 -0.33 4.73e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs6120644 chr20:33023810 G/A cg24642439 chr20:33292090 TP53INP2 0.54 11.73 0.42 6.48e-29 Glomerular filtration rate (creatinine); BRCA cis rs11231017 0.507 rs9633995 chr11:62071215 A/C cg23876832 chr11:62092739 NA 0.32 8.08 0.3 3.18e-15 HIV-1 viral setpoint; BRCA cis rs78456975 0.622 rs11888851 chr2:1518254 C/G cg26248373 chr2:1572462 NA -0.38 -7.91 -0.3 1.13e-14 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.02 14.88 0.51 3.4e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs847577 0.748 rs940430 chr7:97716540 A/G cg24562669 chr7:97807699 LMTK2 0.62 18.68 0.59 1.78e-62 Breast cancer; BRCA trans rs629535 0.590 rs55988608 chr8:70133619 A/G cg21567404 chr3:27674614 NA -0.97 -18.03 -0.58 4.74e-59 Dupuytren's disease; BRCA cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg21535247 chr6:8435926 SLC35B3 0.4 8.96 0.33 3.57e-18 Motion sickness; BRCA cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.84 0.42 2.33e-29 Lung cancer in ever smokers; BRCA cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs2072499 0.750 rs55675376 chr1:156165881 C/T cg24450063 chr1:156163899 SLC25A44 0.94 18.44 0.59 3.44e-61 Testicular germ cell tumor; BRCA cis rs3917254 0.543 rs11123911 chr2:102761538 C/T cg22835712 chr2:102737379 NA -0.49 -8.93 -0.33 4.54e-18 Blood protein levels; BRCA cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg04450456 chr4:17643702 FAM184B -0.38 -11.28 -0.41 4.71e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs921968 0.643 rs13431399 chr2:219469498 G/C cg02176678 chr2:219576539 TTLL4 -0.52 -13.21 -0.46 2.23e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs4268898 0.722 rs7564420 chr2:24414002 C/T cg06627628 chr2:24431161 ITSN2 -0.45 -9.48 -0.35 4.72e-20 Asthma; BRCA cis rs12410462 1.000 rs75360545 chr1:227625419 T/C cg04117972 chr1:227635322 NA 0.49 8.9 0.33 5.78e-18 Major depressive disorder; BRCA cis rs7737355 1.000 rs798415 chr5:130693723 T/G cg06307176 chr5:131281290 NA -0.47 -9.04 -0.34 1.79e-18 Life satisfaction; BRCA cis rs9443645 0.901 rs9443638 chr6:79720867 T/A cg18132916 chr6:79620363 NA -0.48 -10.88 -0.4 2.04e-25 Intelligence (multi-trait analysis); BRCA cis rs1499972 0.941 rs62263115 chr3:117622116 G/A cg07612923 chr3:117604196 NA 0.58 7.92 0.3 1.04e-14 Schizophrenia; BRCA cis rs11190604 0.943 rs7085261 chr10:102209811 G/A cg07080220 chr10:102295463 HIF1AN 0.49 11.34 0.41 2.85e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs908922 0.676 rs7529136 chr1:152516389 T/C cg20991723 chr1:152506922 NA 0.38 8.67 0.32 3.48e-17 Hair morphology; BRCA trans rs61931739 0.500 rs12809868 chr12:34464905 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.5 0.35 3.97e-20 Morning vs. evening chronotype; BRCA cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg23711669 chr6:146136114 FBXO30 0.72 14.81 0.51 7.21e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg10819733 chr22:24237672 NA -0.3 -8.2 -0.31 1.3e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs365132 0.875 rs2962842 chr5:176338955 A/G cg16309518 chr5:176445507 NA -0.41 -10.06 -0.37 3.47e-22 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs17376456 0.877 rs10065056 chr5:93380123 G/T cg21475434 chr5:93447410 FAM172A 0.67 8.72 0.33 2.4e-17 Diabetic retinopathy; BRCA cis rs13082711 0.554 rs6804440 chr3:27398150 C/T cg02860705 chr3:27208620 NA 0.66 11.52 0.41 4.97e-28 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6005807 0.719 rs9620810 chr22:29053727 T/C cg12565055 chr22:29076175 TTC28 0.5 9.47 0.35 5.27e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg04025307 chr7:1156635 C7orf50 0.57 13.92 0.48 1.14e-38 Longevity;Endometriosis; BRCA trans rs9291683 0.554 rs7668175 chr4:10125782 T/C cg26043149 chr18:55253948 FECH -0.4 -8.77 -0.33 1.66e-17 Bone mineral density; BRCA cis rs2576037 0.583 rs8094654 chr18:44527397 C/T cg19077165 chr18:44547161 KATNAL2 -0.62 -13.83 -0.48 3.03e-38 Personality dimensions; BRCA cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs11984145 1.000 rs17171466 chr7:38835926 A/G cg19327137 chr7:38886074 VPS41 0.47 8.56 0.32 8.37e-17 Cognitive performance; BRCA trans rs4689592 0.523 rs6446565 chr4:7074027 A/G cg07817883 chr1:32538562 TMEM39B -0.46 -8.8 -0.33 1.31e-17 Monocyte percentage of white cells; BRCA cis rs1401999 1.000 rs6805913 chr3:183662924 T/G cg20387954 chr3:183756860 HTR3D 0.45 10.05 0.37 3.66e-22 Anterior chamber depth; BRCA cis rs524281 0.861 rs11227411 chr11:65879478 C/T cg16950941 chr11:66035639 RAB1B -0.38 -8.12 -0.31 2.4e-15 Electroencephalogram traits; BRCA cis rs6745190 0.575 rs6706397 chr2:181971800 T/G cg00481216 chr2:181971175 NA 0.38 8.98 0.33 2.95e-18 White blood cell count; BRCA cis rs4240897 1.000 rs4240897 chr1:12042755 A/G cg13216073 chr1:12042593 MFN2 -0.45 -10.71 -0.39 1.02e-24 Tuberculosis; BRCA cis rs1468333 0.694 rs7719684 chr5:137614085 C/G cg27119451 chr5:137514611 BRD8;KIF20A 0.38 7.94 0.3 9.06e-15 Resting heart rate; BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg25036284 chr2:26402008 FAM59B -0.97 -16.2 -0.54 1.09e-49 Gut microbiome composition (summer); BRCA cis rs9815354 0.680 rs73073242 chr3:42015335 G/A cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2404602 1.000 rs2404741 chr15:76851735 C/T cg22467129 chr15:76604101 ETFA -0.46 -10.24 -0.38 7.17e-23 Blood metabolite levels; BRCA trans rs7939886 0.920 rs11534518 chr11:55808146 C/T cg15704280 chr7:45808275 SEPT13 0.61 7.82 0.3 2.14e-14 Myopia (pathological); BRCA cis rs7666738 0.747 rs2865955 chr4:99040518 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs600231 0.651 rs2846862 chr11:65219790 A/G cg01292856 chr11:65242576 NA 0.32 8.14 0.31 2.13e-15 Bone mineral density; BRCA cis rs3125734 0.719 rs3852410 chr10:64037563 A/G cg19640130 chr10:64028056 RTKN2 0.3 8.35 0.31 4.31e-16 Rheumatoid arthritis; BRCA cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg10556349 chr10:835070 NA 0.75 10.1 0.37 2.41e-22 Eosinophil percentage of granulocytes; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.46 -0.32 1.88e-16 Total body bone mineral density; BRCA cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg23583168 chr7:148888333 NA -0.84 -19.69 -0.61 7.7e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg11764359 chr7:65958608 NA 0.56 12.09 0.43 1.85e-30 Aortic root size; BRCA cis rs4713118 0.955 rs9468203 chr6:27688667 A/G cg26587870 chr6:27730563 NA -0.37 -7.85 -0.3 1.75e-14 Parkinson's disease; BRCA cis rs17641971 0.684 rs4873093 chr8:49974740 G/T cg00325661 chr8:49890786 NA 0.38 10.58 0.39 3.29e-24 Blood metabolite levels; BRCA cis rs6964587 1.000 rs756647 chr7:91586389 A/G cg01689657 chr7:91764605 CYP51A1 0.21 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg14019146 chr3:50243930 SLC38A3 0.36 8.96 0.33 3.53e-18 Body mass index; BRCA cis rs477895 0.653 rs7939784 chr11:63910153 C/T cg18225595 chr11:63971243 STIP1 0.52 9.46 0.35 6.01e-20 Mean platelet volume; BRCA cis rs7590720 0.731 rs1864253 chr2:216878008 C/G cg12620499 chr2:216877984 MREG 0.84 27.36 0.73 1.13e-109 Alcohol dependence; BRCA trans rs2797160 0.651 rs1268066 chr6:126035041 C/T cg05039488 chr6:79577232 IRAK1BP1 0.36 8.11 0.31 2.51e-15 Endometrial cancer; BRCA cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg06115741 chr20:33292138 TP53INP2 0.51 11.48 0.41 7.45e-28 Coronary artery disease; BRCA cis rs76419734 0.510 rs4699198 chr4:106645771 G/A cg24545054 chr4:106630052 GSTCD;INTS12 0.57 12.65 0.45 7.2e-33 Post bronchodilator FEV1; BRCA cis rs4595586 0.545 rs7310463 chr12:39368927 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs2882667 0.690 rs11953339 chr5:138259542 T/A cg04439458 chr5:138467593 SIL1 -0.35 -8.61 -0.32 5.84e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg05025164 chr4:1340916 KIAA1530 0.78 15.63 0.53 7.41e-47 Longevity; BRCA cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg18305652 chr10:134549665 INPP5A 0.48 12.74 0.45 2.88e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9467711 0.606 rs9379899 chr6:26603015 T/A cg12826209 chr6:26865740 GUSBL1 0.63 8.28 0.31 7.24e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg03396347 chr1:1875803 NA 0.47 12.04 0.43 3.12e-30 Body mass index; BRCA trans rs11098499 0.954 rs6820115 chr4:120398182 T/C cg25214090 chr10:38739885 LOC399744 0.47 10.99 0.4 7.28e-26 Corneal astigmatism; BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg03354898 chr7:1950403 MAD1L1 -0.48 -9.66 -0.36 1.06e-20 Bipolar disorder and schizophrenia; BRCA cis rs1801251 0.893 rs11687128 chr2:233608901 T/C cg25237894 chr2:233734115 C2orf82 0.4 11.52 0.41 4.8e-28 Coronary artery disease; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg19678392 chr7:94953810 PON1 -0.6 -14.88 -0.51 3.2e-43 Paraoxonase activity; BRCA cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.96 14.55 0.5 1.18e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6546550 0.935 rs7563062 chr2:70050725 G/A cg02498382 chr2:70120550 SNRNP27 -0.48 -10.09 -0.37 2.7e-22 Prevalent atrial fibrillation; BRCA cis rs12760731 0.565 rs12036491 chr1:178163651 C/A cg00404053 chr1:178313656 RASAL2 0.64 7.85 0.3 1.75e-14 Obesity-related traits; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs6540556 0.859 rs11119340 chr1:209940560 A/T cg05527609 chr1:210001259 C1orf107 0.46 8.54 0.32 1.01e-16 Red blood cell count; BRCA cis rs870825 0.616 rs61539306 chr4:185650276 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs514406 0.505 rs146750 chr1:53183447 C/G cg24675658 chr1:53192096 ZYG11B -0.65 -14.23 -0.49 3.9e-40 Monocyte count; BRCA cis rs9463078 0.764 rs1576382 chr6:44957553 G/A cg25276700 chr6:44698697 NA -0.37 -8.54 -0.32 9.76e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs12142240 0.698 rs72885198 chr1:46812888 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA trans rs7829975 0.711 rs4841051 chr8:8685646 C/T cg21775007 chr8:11205619 TDH -0.38 -8.35 -0.31 4.16e-16 Mood instability; BRCA cis rs2016266 0.819 rs4758965 chr12:53662735 C/T cg26875137 chr12:53738046 NA 0.36 9.8 0.36 3.14e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs6565180 0.962 rs6565183 chr16:30382755 T/C cg17640201 chr16:30407289 ZNF48 -0.8 -21.01 -0.64 6.72e-75 Tonsillectomy; BRCA cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg20203395 chr5:56204925 C5orf35 -0.5 -10.15 -0.37 1.54e-22 Initial pursuit acceleration; BRCA trans rs11098499 0.909 rs79704848 chr4:120309351 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs911119 1.000 rs35488434 chr20:23620401 T/C cg16589663 chr20:23618590 CST3 0.47 8.81 0.33 1.2e-17 Chronic kidney disease; BRCA cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08704250 chr15:31115839 NA -0.36 -8.94 -0.33 4.28e-18 Huntington's disease progression; BRCA cis rs9790314 0.690 rs7651087 chr3:160821929 T/C cg03342759 chr3:160939853 NMD3 -0.53 -11.46 -0.41 8.46e-28 Morning vs. evening chronotype; BRCA cis rs13046373 0.508 rs13048637 chr21:31999055 T/G cg24082983 chr21:31802169 KRTAP13-4 0.33 8.25 0.31 8.99e-16 HDL cholesterol; BRCA cis rs4595586 0.679 rs35743713 chr12:39318539 C/G cg26384229 chr12:38710491 ALG10B 0.39 8.65 0.32 4.08e-17 Morning vs. evening chronotype; BRCA cis rs514406 0.668 rs520281 chr1:53365235 G/C cg16325326 chr1:53192061 ZYG11B 0.52 11.12 0.4 2.12e-26 Monocyte count; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg03923535 chr7:1197113 ZFAND2A 0.46 9.31 0.35 2.09e-19 Longevity;Endometriosis; BRCA trans rs617791 0.569 rs11227370 chr11:65747693 C/T cg17712092 chr4:129076599 LARP1B -0.5 -10.94 -0.4 1.19e-25 Breast cancer; BRCA cis rs7772486 0.686 rs9373473 chr6:146082282 A/G cg23711669 chr6:146136114 FBXO30 0.7 16.66 0.55 5.09e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg17063962 chr7:91808500 NA 0.55 12.72 0.45 3.22e-33 Breast cancer; BRCA cis rs910316 0.763 rs175042 chr14:75470833 A/T cg08847533 chr14:75593920 NEK9 -0.8 -19.77 -0.62 3.04e-68 Height; BRCA cis rs6964587 0.967 rs6973896 chr7:91778465 A/G cg01689657 chr7:91764605 CYP51A1 0.22 7.97 0.3 7.19e-15 Breast cancer; BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg27170947 chr2:26402098 FAM59B 0.83 11.63 0.42 1.8e-28 Gut microbiome composition (summer); BRCA cis rs1707322 0.964 rs6697830 chr1:46290477 C/A cg06784218 chr1:46089804 CCDC17 0.45 10.81 0.39 3.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7727544 0.669 rs113823725 chr5:131563501 C/G cg14196790 chr5:131705035 SLC22A5 0.4 10.16 0.37 1.41e-22 Blood metabolite levels; BRCA cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.61 0.36 1.65e-20 Motion sickness; BRCA cis rs796364 0.806 rs11684895 chr2:201009026 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg08000102 chr2:233561755 GIGYF2 -0.62 -13.57 -0.47 4.77e-37 Coronary artery disease; BRCA cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA cis rs9527 0.590 rs7906754 chr10:104782557 T/C cg04362960 chr10:104952993 NT5C2 0.44 9.99 0.37 6.05e-22 Arsenic metabolism; BRCA cis rs9811920 0.809 rs6802817 chr3:99779264 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -13.16 -0.46 3.47e-35 Axial length; BRCA cis rs6964587 0.967 rs10231496 chr7:91741132 T/C cg17063962 chr7:91808500 NA 0.59 13.96 0.48 7.47e-39 Breast cancer; BRCA cis rs12579753 1.000 rs10862374 chr12:82250809 G/C cg07988820 chr12:82153109 PPFIA2 -0.59 -9.69 -0.36 8.49e-21 Resting heart rate; BRCA cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg04455712 chr21:45112962 RRP1B 0.43 11.01 0.4 6.41e-26 Mean corpuscular volume; BRCA cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg04944784 chr2:26401820 FAM59B -1.01 -16.45 -0.55 5.57e-51 Gut microbiome composition (summer); BRCA trans rs7618501 0.633 rs2624843 chr3:49997963 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.3 8.21 0.31 1.22e-15 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.738 rs72918577 chr4:120326701 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.83 0.3 2.07e-14 Corneal astigmatism; BRCA cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg03474202 chr17:45855739 NA -0.47 -12.49 -0.44 3.33e-32 IgG glycosylation; BRCA cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.47e-49 Alzheimer's disease (late onset); BRCA cis rs919433 0.588 rs11690163 chr2:198527507 A/T cg00792783 chr2:198669748 PLCL1 0.39 9.03 0.34 2.08e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg23205692 chr1:25664452 TMEM50A 0.44 10.94 0.4 1.24e-25 Erythrocyte sedimentation rate; BRCA cis rs2806561 0.765 rs643492 chr1:23501354 C/T cg12483005 chr1:23474871 LUZP1 -0.47 -10.43 -0.38 1.26e-23 Height; BRCA cis rs12586317 0.620 rs76293361 chr14:35570889 G/A cg05294307 chr14:35346193 BAZ1A -0.58 -10.21 -0.37 8.65e-23 Psoriasis; BRCA cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg18357645 chr12:58087776 OS9 -0.33 -8.39 -0.32 3.05e-16 Multiple sclerosis; BRCA trans rs11098499 0.954 rs7437420 chr4:120312903 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.19 0.31 1.39e-15 Corneal astigmatism; BRCA trans rs3812049 0.784 rs6889311 chr5:127431285 A/G cg16011800 chr17:1958478 HIC1 -0.56 -9.02 -0.34 2.13e-18 Lymphocyte counts;Red cell distribution width; BRCA cis rs6580649 0.883 rs7967762 chr12:48420214 C/T cg24011408 chr12:48396354 COL2A1 -0.48 -8.06 -0.3 3.77e-15 Lung cancer; BRCA cis rs9790314 0.905 rs4518145 chr3:160950030 T/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.33 -0.49 1.38e-40 Morning vs. evening chronotype; BRCA cis rs2032447 0.802 rs12346 chr6:26097046 T/C cg03517284 chr6:25882590 NA -0.45 -9.23 -0.34 3.9e-19 Intelligence (multi-trait analysis); BRCA cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg11764359 chr7:65958608 NA 0.8 19.28 0.61 1.17e-65 Aortic root size; BRCA cis rs3739998 0.647 rs7920686 chr10:30317838 A/G cg12786570 chr10:30316432 KIAA1462 0.43 9.4 0.35 9.39e-20 Coronary heart disease; BRCA cis rs3125734 0.633 rs7088891 chr10:64034019 G/T cg19640130 chr10:64028056 RTKN2 -0.32 -8.87 -0.33 7.33e-18 Rheumatoid arthritis; BRCA trans rs7615952 0.641 rs6805074 chr3:125772274 T/A cg07211511 chr3:129823064 LOC729375 -0.63 -11.03 -0.4 4.99e-26 Blood pressure (smoking interaction); BRCA cis rs3858526 0.959 rs11039540 chr11:5928334 C/T cg13902645 chr11:5959945 NA -0.56 -11.47 -0.41 7.69e-28 DNA methylation (variation); BRCA cis rs7927771 0.542 rs3886262 chr11:47817010 T/G cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.36e-20 Subjective well-being; BRCA trans rs6561151 0.957 rs3764147 chr13:44457925 C/T cg17145862 chr1:211918768 LPGAT1 -0.41 -8.41 -0.32 2.71e-16 Crohn's disease; BRCA trans rs853679 0.607 rs34950484 chr6:28278688 G/A cg01620082 chr3:125678407 NA -0.84 -9.78 -0.36 3.96e-21 Depression; BRCA cis rs5750830 0.594 rs1010169 chr22:39778167 C/T cg11247378 chr22:39784982 NA 0.64 14.52 0.5 1.69e-41 Intelligence (multi-trait analysis); BRCA trans rs6951245 0.706 rs28483034 chr7:1170171 C/A cg13565492 chr6:43139072 SRF -0.81 -12.57 -0.45 1.62e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2832077 0.943 rs4816332 chr21:30201706 T/C cg08807101 chr21:30365312 RNF160 -0.47 -8.01 -0.3 5.52e-15 Cognitive test performance; BRCA cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg25767906 chr1:53392781 SCP2 -0.39 -8.79 -0.33 1.41e-17 Monocyte count; BRCA cis rs17376456 0.877 rs7701011 chr5:93311456 G/A cg25358565 chr5:93447407 FAM172A 1.19 18.82 0.6 3.54e-63 Diabetic retinopathy; BRCA cis rs9486719 0.843 rs2472876 chr6:96845723 A/G cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs5753618 0.504 rs9609297 chr22:31893731 G/T cg02404636 chr22:31891804 SFI1 0.45 9.05 0.34 1.64e-18 Colorectal cancer; BRCA cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.9 0.4 1.78e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 0.655 rs5745336 chr1:76273519 G/A cg22875332 chr1:76189707 ACADM 0.61 11.64 0.42 1.57e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg26647111 chr11:31128758 NA 0.43 9.54 0.35 2.94e-20 Red blood cell count; BRCA cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs6743226 0.811 rs10933537 chr2:242154930 C/G cg10021735 chr2:242295487 FARP2 -0.32 -8.86 -0.33 7.95e-18 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs12986413 0.651 rs2238612 chr19:2149694 C/T cg09261902 chr19:2140048 AP3D1 -0.39 -9.89 -0.36 1.5e-21 Height; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg03923535 chr7:1197113 ZFAND2A 0.46 9.36 0.35 1.36e-19 Longevity;Endometriosis; BRCA trans rs10506458 0.915 rs2013042 chr12:63394211 A/G cg22491629 chr6:157744540 C6orf35 -0.61 -11.89 -0.43 1.36e-29 Hemostatic factors and hematological phenotypes; BRCA trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.18 -0.56 1.12e-54 Intelligence (multi-trait analysis); BRCA cis rs28374715 0.617 rs28626792 chr15:41562218 A/G cg18705301 chr15:41695430 NDUFAF1 -0.56 -12.13 -0.43 1.23e-30 Ulcerative colitis; BRCA cis rs6598955 0.543 rs17163720 chr1:26549399 A/G cg04990556 chr1:26633338 UBXN11 -0.69 -12.02 -0.43 3.65e-30 Obesity-related traits; BRCA cis rs6540556 0.723 rs3766618 chr1:209895437 G/T cg05527609 chr1:210001259 C1orf107 -0.52 -8.68 -0.32 3.24e-17 Red blood cell count; BRCA cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg09658497 chr7:2847517 GNA12 0.44 9.36 0.35 1.28e-19 Height; BRCA cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg20673091 chr1:2541236 MMEL1 -0.46 -11.88 -0.43 1.56e-29 Ulcerative colitis; BRCA cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg24531977 chr5:56204891 C5orf35 -0.79 -16.28 -0.54 4.15e-50 Initial pursuit acceleration; BRCA cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg04025307 chr7:1156635 C7orf50 -0.42 -7.98 -0.3 7.04e-15 Bronchopulmonary dysplasia; BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg04944784 chr2:26401820 FAM59B 0.82 11.32 0.41 3.33e-27 Gut microbiome composition (summer); BRCA cis rs1712517 0.740 rs11191643 chr10:105057561 C/G cg05636881 chr10:105038444 INA 0.36 8.09 0.3 2.93e-15 Migraine; BRCA cis rs6545883 0.859 rs13004855 chr2:61505072 C/T cg15711740 chr2:61764176 XPO1 0.49 11.97 0.43 6.11e-30 Tuberculosis; BRCA cis rs2251381 0.750 rs2255055 chr21:30537045 C/T cg08807101 chr21:30365312 RNF160 0.57 12.45 0.44 5.37e-32 Selective IgA deficiency; BRCA cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg08355456 chr11:67383691 NA 0.41 8.54 0.32 9.87e-17 Mean corpuscular volume; BRCA cis rs2346177 0.580 rs1530628 chr2:46670941 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.38 -8.5 -0.32 1.3e-16 HDL cholesterol; BRCA cis rs9296092 0.500 rs9469504 chr6:33527243 G/A cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg24101359 chr6:42928495 GNMT 0.62 15.16 0.51 1.5e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg12444411 chr7:2802554 GNA12 -0.3 -7.82 -0.3 2.2e-14 Height; BRCA cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.3 -0.41 4e-27 IgG glycosylation; BRCA cis rs1832871 0.599 rs7752547 chr6:158751163 C/T cg07215822 chr6:158701037 NA 0.46 9.31 0.35 1.95e-19 Height; BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg22764044 chr5:178986830 RUFY1 0.48 13.19 0.46 2.52e-35 Lung cancer; BRCA cis rs861020 0.771 rs629150 chr1:209998467 C/T cg09163369 chr1:210001066 C1orf107 0.63 11.94 0.43 8.75e-30 Orofacial clefts; BRCA cis rs4237845 0.735 rs11172375 chr12:58291574 G/C cg00677455 chr12:58241039 CTDSP2 0.54 12.39 0.44 9.89e-32 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.535 rs7671759 chr4:120248094 A/C cg25214090 chr10:38739885 LOC399744 0.46 10.29 0.38 4.47e-23 Corneal astigmatism; BRCA cis rs10883723 0.810 rs7094751 chr10:104274818 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.06 0.62 8.66e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs8114671 0.904 rs6060197 chr20:33654315 C/T cg07148914 chr20:33460835 GGT7 -0.43 -9.17 -0.34 6.56e-19 Height; BRCA cis rs7918232 0.941 rs7907988 chr10:27444344 T/G cg14240646 chr10:27532245 ACBD5 -0.63 -9.65 -0.36 1.19e-20 Breast cancer; BRCA cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs7945705 0.837 rs10769966 chr11:8847041 C/A cg21881798 chr11:8931708 C11orf17;ST5 0.42 9.02 0.34 2.22e-18 Hemoglobin concentration; BRCA cis rs4363385 0.747 rs6689609 chr1:152967588 G/A cg21543102 chr1:152974771 SPRR3 -0.3 -8.61 -0.32 5.54e-17 Inflammatory skin disease; BRCA cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg21573476 chr21:45109991 RRP1B -0.4 -10.82 -0.39 3.57e-25 Mean corpuscular volume; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg03923535 chr7:1197113 ZFAND2A 0.52 11.05 0.4 4.27e-26 Longevity;Endometriosis; BRCA cis rs9814567 1.000 rs6801596 chr3:134252114 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.11 -0.34 1.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg08975724 chr8:8085496 FLJ10661 0.44 8.9 0.33 5.59e-18 Neuroticism; BRCA trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg00717180 chr2:96193071 NA 0.31 8.68 0.32 3.39e-17 Height; BRCA cis rs9291683 0.552 rs17187075 chr4:9990328 G/C cg00071950 chr4:10020882 SLC2A9 0.59 14.53 0.5 1.53e-41 Bone mineral density; BRCA trans rs2204008 0.811 rs11520277 chr12:38359611 G/A cg06521331 chr12:34319734 NA -0.44 -8.35 -0.31 4.37e-16 Bladder cancer; BRCA cis rs7593730 0.537 rs1457231 chr2:161101562 C/T cg22609984 chr2:161126801 NA 0.38 8.2 0.31 1.28e-15 Type 2 diabetes; BRCA cis rs12368653 0.591 rs1038914 chr12:58011066 G/A cg12615879 chr12:58013172 SLC26A10 -0.33 -9.21 -0.34 4.74e-19 Multiple sclerosis; BRCA trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg20587970 chr11:113659929 NA -1.26 -22.92 -0.67 2.71e-85 Hip circumference adjusted for BMI; BRCA cis rs760805 0.965 rs4648883 chr1:25261203 T/C cg22509179 chr1:25234806 RUNX3 -0.57 -14.58 -0.5 9e-42 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22509189 chr2:225307070 NA 0.47 10.09 0.37 2.57e-22 IgE levels in asthmatics (D.p. specific); BRCA cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg13319975 chr6:146136371 FBXO30 -0.37 -8.44 -0.32 2.09e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs10193935 0.892 rs12612372 chr2:42414035 A/G cg27598129 chr2:42591480 NA -0.94 -15.03 -0.51 6.18e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs853679 0.517 rs9283884 chr6:28135660 C/G cg18032046 chr6:28092343 ZSCAN16 0.48 7.82 0.3 2.26e-14 Depression; BRCA cis rs7772486 0.790 rs9403756 chr6:146257761 C/G cg13319975 chr6:146136371 FBXO30 0.43 9.74 0.36 5.39e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs17401966 0.838 rs34636442 chr1:10427459 T/G cg03954927 chr1:10346856 KIF1B 0.43 13.54 0.47 6.56e-37 Hepatocellular carcinoma; BRCA cis rs4819052 0.851 rs7276103 chr21:46666078 G/A cg06618935 chr21:46677482 NA -0.36 -8.25 -0.31 9.14e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.16e-15 Uric acid levels; BRCA trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg11707556 chr5:10655725 ANKRD33B 0.48 11.12 0.4 2.23e-26 Height; BRCA cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 18.9 0.6 1.21e-63 Smoking behavior; BRCA cis rs74181299 0.620 rs6546123 chr2:65303582 T/C cg05010058 chr2:65284262 CEP68 -0.29 -7.99 -0.3 6.43e-15 Pulse pressure; BRCA cis rs495337 0.736 rs599195 chr20:48464795 A/T cg17835207 chr20:48524531 SPATA2 -0.48 -10.11 -0.37 2.13e-22 Psoriasis; BRCA cis rs7914558 1.000 rs2275271 chr10:104814162 T/C cg04362960 chr10:104952993 NT5C2 0.43 10.39 0.38 1.88e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs897080 0.515 rs1067356 chr2:44663072 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 8.16 0.31 1.77e-15 Height; BRCA cis rs4948102 0.551 rs4275190 chr7:56104388 C/T cg09872392 chr7:56161020 PHKG1 -0.47 -11.65 -0.42 1.47e-28 Plasma homocysteine levels (post-methionine load test); BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg05457628 chr5:178986728 RUFY1 0.4 9.14 0.34 8.06e-19 Lung cancer; BRCA cis rs5758511 0.680 rs1001586 chr22:42670293 G/T cg00645731 chr22:42541494 CYP2D7P1 0.58 11.17 0.4 1.34e-26 Birth weight; BRCA cis rs13315871 0.929 rs71311854 chr3:58319159 G/A cg20936604 chr3:58311152 NA -0.65 -8.24 -0.31 9.48e-16 Cholesterol, total; BRCA cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg12219531 chr12:120966889 COQ5 0.54 11.06 0.4 4.06e-26 High light scatter reticulocyte count; BRCA trans rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.57 -14.12 -0.49 1.27e-39 Brugada syndrome; BRCA cis rs7124681 0.584 rs1471712 chr11:47912150 G/A cg20307385 chr11:47447363 PSMC3 -0.41 -9.35 -0.35 1.45e-19 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs7246657 0.722 rs10417576 chr19:38119212 A/C cg18154014 chr19:37997991 ZNF793 0.5 9.59 0.35 1.99e-20 Coronary artery calcification; BRCA cis rs30380 1.000 rs30187 chr5:96124330 T/C cg16492584 chr5:96139282 ERAP1 -0.31 -7.98 -0.3 6.64e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs8058578 1.000 rs56656810 chr16:30788759 C/A cg02466173 chr16:30829666 NA -0.52 -11.18 -0.4 1.29e-26 Multiple myeloma; BRCA cis rs3784262 0.669 rs6493981 chr15:58352923 T/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.2 -0.37 9.78e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1421811 0.606 rs10057069 chr5:32716589 A/G cg16267343 chr5:32710456 NPR3 0.57 10.82 0.39 3.47e-25 Blood pressure; BRCA cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.6 -0.39 2.8e-24 Putamen volume; BRCA cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg02079420 chr8:82753780 SNX16 0.32 8.64 0.32 4.49e-17 Diastolic blood pressure; BRCA cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg22875332 chr1:76189707 ACADM 0.62 14.13 0.49 1.26e-39 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs17685 0.712 rs869805 chr7:75688596 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 28.34 0.75 4.9e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4713118 0.547 rs2116981 chr6:28067951 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.49e-15 Parkinson's disease; BRCA cis rs7474896 0.583 rs11011346 chr10:38009483 C/T cg25427524 chr10:38739819 LOC399744 -0.51 -8.81 -0.33 1.14e-17 Obesity (extreme); BRCA cis rs7149337 0.805 rs4350491 chr14:51675798 A/G cg23942311 chr14:51606299 NA 0.41 11.5 0.41 6.11e-28 Cancer; BRCA cis rs6840360 0.638 rs6816002 chr4:152589439 C/T cg22705602 chr4:152727874 NA -0.36 -9.86 -0.36 2e-21 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs6751398 chr2:10738972 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs6434928 1 rs6434928 chr2:198304577 G/A cg00792783 chr2:198669748 PLCL1 0.38 8.58 0.32 7.16e-17 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs72772090 0.522 rs17086504 chr5:96011023 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -8.18 -0.31 1.53e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9368481 0.502 rs3933232 chr6:26877446 T/C cg12292205 chr6:26970375 C6orf41 0.64 14.57 0.5 9.93e-42 Autism spectrum disorder or schizophrenia; BRCA cis rs3820928 0.874 rs13403281 chr2:227880769 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.54 -0.32 9.58e-17 Pulmonary function; BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 25.48 0.71 2.27e-99 Platelet count; BRCA cis rs1865760 0.534 rs2032444 chr6:26046744 T/G cg17691542 chr6:26056736 HIST1H1C 0.67 13.67 0.48 1.6e-37 Height; BRCA cis rs7914558 0.933 rs10883814 chr10:104737404 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.77 0.39 5.46e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs587242 0.955 rs12566597 chr1:96978626 A/G cg10631902 chr5:14652156 NA -0.43 -10.65 -0.39 1.79e-24 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs733175 0.951 rs6846692 chr4:10031133 C/G cg00071950 chr4:10020882 SLC2A9 0.42 8.03 0.3 4.61e-15 Psychosis and Alzheimer's disease; BRCA cis rs7666738 0.830 rs34244876 chr4:99031336 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.58 0.32 7.26e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs826838 1.000 rs11514441 chr12:38775190 C/T cg13010199 chr12:38710504 ALG10B 0.56 12.36 0.44 1.25e-31 Heart rate; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg23285459 chr7:2802560 GNA12 0.35 8.98 0.33 2.92e-18 Height; BRCA trans rs3733585 0.699 rs28837683 chr4:9959808 C/T cg26043149 chr18:55253948 FECH -0.37 -8.12 -0.31 2.34e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs4332037 0.851 rs28728306 chr7:1961814 C/A cg11693508 chr17:37793320 STARD3 0.68 12.95 0.46 3.06e-34 Bipolar disorder; BRCA cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.41e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg19784903 chr17:45786737 TBKBP1 -0.37 -8.69 -0.33 2.94e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7086627 0.515 rs7088877 chr10:82208860 C/G cg00277334 chr10:82204260 NA -0.85 -24.93 -0.7 2.31e-96 Post bronchodilator FEV1; BRCA cis rs4665809 1.000 rs11126340 chr2:26253255 A/G cg04944784 chr2:26401820 FAM59B -0.66 -10.66 -0.39 1.56e-24 Gut microbiome composition (summer); BRCA cis rs3749237 0.964 rs1799845 chr3:49847623 A/G cg03060546 chr3:49711283 APEH 0.51 10.71 0.39 1.02e-24 Resting heart rate; BRCA cis rs9815354 0.812 rs73071203 chr3:41977464 A/C cg03022575 chr3:42003672 ULK4 0.7 9.67 0.36 9.51e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA trans rs4596713 0.538 rs4592105 chr9:71754305 T/G cg16512924 chr15:28394682 HERC2 0.42 9.84 0.36 2.36e-21 Headache; BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -9.21 -0.34 4.67e-19 Cognitive function; BRCA cis rs17376456 0.809 rs13177800 chr5:93307350 T/C cg21475434 chr5:93447410 FAM172A 0.68 8.62 0.32 5.18e-17 Diabetic retinopathy; BRCA cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg06784218 chr1:46089804 CCDC17 0.49 11.81 0.42 3.11e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9815354 0.812 rs17218264 chr3:41975847 C/T cg03022575 chr3:42003672 ULK4 -0.69 -9.67 -0.36 9.84e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24308560 chr3:49941425 MST1R -0.4 -8.6 -0.32 6.08e-17 Intelligence (multi-trait analysis); BRCA cis rs10911232 0.507 rs4575047 chr1:182976028 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.75 0.55 1.71e-52 Hypertriglyceridemia; BRCA cis rs7635838 0.654 rs347585 chr3:11286220 C/T cg00170343 chr3:11313890 ATG7 0.42 8.05 0.3 4.02e-15 HDL cholesterol; BRCA cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg13010199 chr12:38710504 ALG10B 0.44 9.21 0.34 4.54e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs1215050 0.791 rs10856931 chr4:98819306 C/T cg05340658 chr4:99064831 C4orf37 0.46 10.63 0.39 2.06e-24 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs495337 0.721 rs6125822 chr20:48548766 T/G cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg18479299 chr3:125709523 NA -0.51 -8.31 -0.31 5.66e-16 Blood pressure (smoking interaction); BRCA cis rs9487051 0.872 rs7773331 chr6:109609208 C/T cg12927641 chr6:109611667 NA -0.42 -10.81 -0.39 4.04e-25 Reticulocyte fraction of red cells; BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.82 14.17 0.49 8.1e-40 Alzheimer's disease; BRCA trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg11887960 chr12:57824829 NA 0.52 8.12 0.31 2.32e-15 Lung disease severity in cystic fibrosis; BRCA cis rs3784262 0.643 rs2453280 chr15:58368379 C/T cg12031962 chr15:58353849 ALDH1A2 0.32 8.14 0.31 2.07e-15 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg03396347 chr1:1875803 NA -0.43 -10.92 -0.4 1.38e-25 Body mass index; BRCA cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -8.93 -0.33 4.67e-18 Monocyte percentage of white cells; BRCA trans rs208515 0.556 rs12214562 chr6:66681011 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.05 0.54 5.8e-49 Exhaled nitric oxide levels; BRCA trans rs2204008 0.537 rs28680519 chr12:38502946 C/T cg06521331 chr12:34319734 NA -0.49 -9.17 -0.34 6.51e-19 Bladder cancer; BRCA cis rs10193935 1.000 rs57883795 chr2:42387926 C/T cg27598129 chr2:42591480 NA -1.0 -15.03 -0.51 6.31e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs7914558 1.000 rs12255047 chr10:104760752 G/A cg04362960 chr10:104952993 NT5C2 0.43 10.47 0.38 8.76e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1499972 0.941 rs55958116 chr3:117672772 C/T cg07612923 chr3:117604196 NA 0.6 8.2 0.31 1.35e-15 Schizophrenia; BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg22963979 chr7:1858916 MAD1L1 -0.45 -9.05 -0.34 1.65e-18 Bipolar disorder and schizophrenia; BRCA cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg06453172 chr10:134556979 INPP5A -0.55 -11.59 -0.42 2.56e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg13256891 chr4:100009986 ADH5 0.55 10.28 0.38 4.94e-23 Smoking initiation; BRCA cis rs6582630 0.502 rs11495393 chr12:38341194 T/C cg26384229 chr12:38710491 ALG10B 0.7 16.24 0.54 6.39e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs11229555 0.874 rs11229505 chr11:58274155 T/C cg15696309 chr11:58395628 NA -0.53 -11.49 -0.41 6.8e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs796364 0.806 rs4673634 chr2:200863349 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.67 10.46 0.38 9.82e-24 Schizophrenia; BRCA trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 3.77e-39 Extrinsic epigenetic age acceleration; BRCA cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.17 0.74 4.21e-114 Chronic sinus infection; BRCA cis rs9858542 0.903 rs35999162 chr3:49597230 C/G cg03060546 chr3:49711283 APEH -0.51 -10.16 -0.37 1.44e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg25405998 chr7:65216604 CCT6P1 0.43 9.03 0.34 1.95e-18 Calcium levels; BRCA trans rs61931739 0.534 rs11053072 chr12:34202399 A/C cg13010199 chr12:38710504 ALG10B 0.49 9.53 0.35 3.12e-20 Morning vs. evening chronotype; BRCA cis rs344364 0.511 rs2982453 chr16:1949520 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs6815814 0.904 rs3924113 chr4:38796255 G/T cg02016764 chr4:38805732 TLR1 -0.63 -9.61 -0.36 1.63e-20 Breast cancer; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg11905131 chr22:24372483 LOC391322 0.53 11.83 0.42 2.39e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg04166393 chr7:2884313 GNA12 -0.48 -9.0 -0.34 2.49e-18 Height; BRCA cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg04013166 chr16:89971882 TCF25 0.52 9.49 0.35 4.47e-20 Skin colour saturation; BRCA trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.49 -0.32 1.43e-16 Extrinsic epigenetic age acceleration; BRCA cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg19077165 chr18:44547161 KATNAL2 0.38 8.22 0.31 1.14e-15 Personality dimensions; BRCA cis rs72615157 0.634 rs79986079 chr7:99802044 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.63 10.75 0.39 6.8e-25 Lung function (FEV1/FVC); BRCA cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.62 0.36 1.54e-20 Menopause (age at onset); BRCA cis rs870825 0.616 rs28618216 chr4:185648998 T/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs7395581 0.918 rs1375688 chr11:47327217 G/A cg25783544 chr11:47291846 MADD 0.43 9.64 0.36 1.23e-20 HDL cholesterol; BRCA cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg18230493 chr5:56204884 C5orf35 -0.71 -13.57 -0.47 4.81e-37 Initial pursuit acceleration; BRCA cis rs7301826 0.627 rs73162873 chr12:131296013 A/G cg11011512 chr12:131303247 STX2 0.52 13.62 0.47 2.92e-37 Plasma plasminogen activator levels; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.71 15.49 0.52 3.32e-46 Lymphocyte counts; BRCA cis rs758324 0.898 rs11958749 chr5:131166014 T/C cg06307176 chr5:131281290 NA 0.56 11.84 0.42 2.26e-29 Alzheimer's disease in APOE e4- carriers; BRCA cis rs9649213 0.614 rs3944111 chr7:98005766 C/T cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.88 -0.53 4.07e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg01324343 chr3:183735012 ABCC5 0.8 19.97 0.62 2.76e-69 Anterior chamber depth; BRCA cis rs6570726 0.935 rs428659 chr6:145827039 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs9790314 1.000 rs336591 chr3:161078080 A/G cg03342759 chr3:160939853 NMD3 -0.54 -11.61 -0.42 2.17e-28 Morning vs. evening chronotype; BRCA trans rs11098499 0.866 rs6857892 chr4:120282696 G/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs9393777 0.513 rs926300 chr6:27059443 A/T cg12292205 chr6:26970375 C6orf41 -0.64 -9.99 -0.37 6.45e-22 Intelligence (multi-trait analysis); BRCA cis rs7959452 0.590 rs28778648 chr12:69771911 C/A cg14784868 chr12:69753453 YEATS4 0.66 19.09 0.6 1.27e-64 Blood protein levels; BRCA trans rs4698048 0.506 rs6833292 chr4:10272429 C/T cg26043149 chr18:55253948 FECH -0.47 -10.9 -0.4 1.66e-25 Skin aging (microtopography measurement); BRCA cis rs11098499 0.754 rs1980027 chr4:120251577 C/T cg09307838 chr4:120376055 NA 0.64 13.8 0.48 4.15e-38 Corneal astigmatism; BRCA cis rs8114671 0.551 rs4911162 chr20:33411425 G/C cg24642439 chr20:33292090 TP53INP2 0.45 9.82 0.36 2.75e-21 Height; BRCA cis rs757081 0.667 rs476890 chr11:17209962 A/G cg15432903 chr11:17409602 KCNJ11 -0.46 -8.68 -0.32 3.16e-17 Systolic blood pressure; BRCA cis rs1707322 0.963 rs1768815 chr1:46528603 G/A cg06784218 chr1:46089804 CCDC17 -0.44 -10.5 -0.38 6.67e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7927771 1.000 rs7120333 chr11:47817441 C/T cg18512352 chr11:47633146 NA -0.35 -8.35 -0.31 4.17e-16 Subjective well-being; BRCA cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg12698349 chr2:225449008 CUL3 0.6 13.23 0.46 1.76e-35 IgE levels in asthmatics (D.p. specific); BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg00149659 chr3:10157352 C3orf10 0.8 13.78 0.48 5.12e-38 Alzheimer's disease; BRCA cis rs3733585 0.673 rs4312757 chr4:9956145 T/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.73e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6964587 1.000 rs6979085 chr7:91673623 C/T cg17063962 chr7:91808500 NA 0.53 12.67 0.45 5.63e-33 Breast cancer; BRCA cis rs17270561 0.636 rs1165216 chr6:25797971 G/A cg17691542 chr6:26056736 HIST1H1C 0.43 9.27 0.34 2.89e-19 Iron status biomarkers; BRCA cis rs4566357 0.787 rs12475134 chr2:227880511 C/T cg11843606 chr2:227700838 RHBDD1 -0.43 -8.81 -0.33 1.16e-17 Coronary artery disease; BRCA cis rs17601876 0.651 rs12908960 chr15:51545860 G/A cg19946085 chr15:51559439 CYP19A1 -0.33 -8.7 -0.33 2.71e-17 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs977987 0.806 rs4888405 chr16:75428196 A/C cg03315344 chr16:75512273 CHST6 0.54 12.66 0.45 6.32e-33 Dupuytren's disease; BRCA cis rs12579753 0.879 rs11115008 chr12:82164859 C/T cg07988820 chr12:82153109 PPFIA2 -0.68 -11.8 -0.42 3.32e-29 Resting heart rate; BRCA cis rs3617 0.573 rs4687682 chr3:52916939 T/C cg11645453 chr3:52864694 ITIH4 -0.35 -9.17 -0.34 6.66e-19 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.500 rs11053166 chr12:34385898 A/C cg26384229 chr12:38710491 ALG10B -0.72 -15.65 -0.53 5.53e-47 Morning vs. evening chronotype; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg21747090 chr2:27597821 SNX17 -0.45 -9.81 -0.36 3.05e-21 Total body bone mineral density; BRCA cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg02079420 chr8:82753780 SNX16 -0.36 -7.92 -0.3 1.05e-14 Diastolic blood pressure; BRCA cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg17971929 chr21:40555470 PSMG1 -0.6 -13.11 -0.46 6.05e-35 Cognitive function; BRCA cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 9.31 0.35 2.06e-19 Renal function-related traits (BUN); BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.21 -0.31 1.19e-15 Total body bone mineral density; BRCA cis rs7737355 0.947 rs11242081 chr5:130908135 T/C cg06307176 chr5:131281290 NA 0.53 10.4 0.38 1.64e-23 Life satisfaction; BRCA trans rs11098499 0.863 rs3775854 chr4:120471971 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.39 8.02 0.3 4.99e-15 Tonsillectomy; BRCA cis rs4478858 0.735 rs6681286 chr1:31799384 G/C cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.03 0.43 3.31e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg17414380 chr19:19431394 KIAA0892;SF4 0.46 9.47 0.35 5.33e-20 Tonsillectomy; BRCA cis rs6782228 0.606 rs2712404 chr3:128332679 C/T cg16766828 chr3:128327626 NA 0.4 8.88 0.33 6.96e-18 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA cis rs11051970 0.704 rs7312698 chr12:32554695 G/T cg02745156 chr12:32552066 NA 0.25 8.47 0.32 1.68e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.12 0.4 2.24e-26 Bipolar disorder; BRCA cis rs1707322 0.927 rs11211194 chr1:46282084 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.81 0.39 3.85e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs708547 0.957 rs781667 chr4:57798469 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 10.83 0.39 3.17e-25 Response to bleomycin (chromatid breaks); BRCA cis rs7613875 0.620 rs13079006 chr3:49996924 G/T cg24110177 chr3:50126178 RBM5 -0.51 -14.42 -0.5 4.93e-41 Body mass index; BRCA cis rs9790314 0.663 rs55888276 chr3:160651406 A/G cg03342759 chr3:160939853 NMD3 0.44 8.54 0.32 9.71e-17 Morning vs. evening chronotype; BRCA cis rs11779988 0.545 rs431961 chr8:17786204 T/G cg01800426 chr8:17659068 MTUS1 -0.4 -8.41 -0.32 2.77e-16 Breast cancer; BRCA cis rs1008375 0.931 rs10008337 chr4:17593849 G/C cg16339924 chr4:17578868 LAP3 0.67 17.11 0.56 2.65e-54 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg05347473 chr6:146136440 FBXO30 -0.4 -7.91 -0.3 1.14e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg04450456 chr4:17643702 FAM184B 0.37 9.91 0.36 1.28e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg03188948 chr7:1209495 NA 0.57 10.82 0.39 3.57e-25 Longevity;Endometriosis; BRCA cis rs28735056 0.967 rs56328473 chr18:77636101 C/T cg20368463 chr18:77673604 PQLC1 -0.35 -8.06 -0.3 3.67e-15 Schizophrenia; BRCA cis rs6540559 0.673 rs7525951 chr1:210018306 C/T cg22029157 chr1:209979665 IRF6 -0.4 -7.84 -0.3 1.83e-14 Cleft lip with or without cleft palate; BRCA trans rs60843830 0.661 rs7588043 chr2:104979 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.49 9.42 0.35 8.36e-20 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs365132 1.000 rs365132 chr5:176378574 G/T cg16309518 chr5:176445507 NA -0.52 -13.42 -0.47 2.36e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12986413 0.624 rs2159213 chr19:2136102 T/C cg09261902 chr19:2140048 AP3D1 0.41 10.81 0.39 4.02e-25 Height; BRCA cis rs6912958 0.781 rs6940150 chr6:88287114 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.43 -0.32 2.27e-16 Monocyte percentage of white cells; BRCA cis rs3818285 0.544 rs9787456 chr10:111711822 A/G cg00817464 chr10:111662876 XPNPEP1 -0.41 -10.23 -0.38 7.66e-23 Superior crus of antihelix expression; BRCA cis rs11098499 0.754 rs28643450 chr4:120245242 G/A cg09307838 chr4:120376055 NA 0.64 14.0 0.48 4.78e-39 Corneal astigmatism; BRCA cis rs312274 0.550 rs11179040 chr12:41311370 T/G cg17827154 chr12:41323612 CNTN1 -0.42 -10.5 -0.38 6.95e-24 Metabolite levels (X-11787); BRCA cis rs9341808 0.754 rs10806185 chr6:80954511 G/A cg08355045 chr6:80787529 NA 0.39 9.86 0.36 1.97e-21 Sitting height ratio; BRCA cis rs427394 0.802 rs274721 chr5:6719164 C/T cg10857441 chr5:6722123 POLS -0.33 -10.96 -0.4 1.03e-25 Menopause (age at onset); BRCA cis rs7098414 0.511 rs10887828 chr10:82151470 T/C cg01528321 chr10:82214614 TSPAN14 0.67 14.22 0.49 4.49e-40 Post bronchodilator FEV1; BRCA cis rs798766 1.000 rs1374469 chr4:1724799 C/T cg10756475 chr4:1757242 NA 0.39 8.9 0.33 5.88e-18 Bladder cancer;Urinary bladder cancer; BRCA cis rs703842 0.616 rs10877023 chr12:58224199 C/A cg04478727 chr12:58166393 METTL1;FAM119B 0.45 8.44 0.32 2.12e-16 Multiple sclerosis; BRCA cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg13256891 chr4:100009986 ADH5 -0.53 -9.91 -0.37 1.23e-21 Alcohol dependence; BRCA cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg21770322 chr7:97807741 LMTK2 -0.43 -11.32 -0.41 3.23e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs524281 0.861 rs11227409 chr11:65870938 A/G cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4.15e-15 Electroencephalogram traits; BRCA cis rs1401999 0.690 rs6773408 chr3:183716609 G/T cg01324343 chr3:183735012 ABCC5 0.67 15.74 0.53 1.94e-47 Anterior chamber depth; BRCA cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.15e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9649465 1.000 rs608447 chr7:123395983 A/G cg04330084 chr7:123175371 IQUB 0.31 8.41 0.32 2.62e-16 Migraine; BRCA cis rs1506636 1.000 rs60689684 chr7:123370403 C/T cg03229431 chr7:123269106 ASB15 0.63 13.06 0.46 1.06e-34 Plateletcrit;Platelet count; BRCA cis rs4363385 0.597 rs55667413 chr1:152976849 G/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.57e-16 Inflammatory skin disease; BRCA cis rs4319547 1.000 rs4319547 chr12:123079035 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -10.1 -0.37 2.37e-22 Body mass index; BRCA cis rs7474896 0.537 rs1208587 chr10:38207759 A/G cg25427524 chr10:38739819 LOC399744 0.57 10.84 0.39 2.95e-25 Obesity (extreme); BRCA cis rs875971 0.862 rs778736 chr7:65813848 C/T cg18876405 chr7:65276391 NA 0.5 11.2 0.41 1.06e-26 Aortic root size; BRCA cis rs1994135 0.617 rs1384590 chr12:33734271 C/T cg06521331 chr12:34319734 NA -0.43 -8.03 -0.3 4.55e-15 Resting heart rate; BRCA cis rs2882667 0.858 rs11242447 chr5:138426173 T/C cg04439458 chr5:138467593 SIL1 -0.43 -10.73 -0.39 8.6e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg11833968 chr6:79620685 NA -0.43 -9.59 -0.35 1.8899999999999998e-20 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.571 rs7970136 chr12:38531951 G/C cg26384229 chr12:38710491 ALG10B -0.44 -10.15 -0.37 1.47e-22 Bladder cancer; BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg22920501 chr2:26401640 FAM59B -0.66 -11.48 -0.41 7.08e-28 Gut microbiome composition (summer); BRCA cis rs868036 1.000 rs7168156 chr15:68102933 T/C cg05925327 chr15:68127851 NA -0.31 -7.9 -0.3 1.23e-14 Restless legs syndrome; BRCA cis rs10781543 0.839 rs4379550 chr9:139376426 C/T cg14019695 chr9:139328340 INPP5E -0.42 -11.51 -0.41 5.19e-28 Monocyte percentage of white cells; BRCA cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.57 0.76 9.6e-122 Cognitive ability; BRCA cis rs10838687 0.736 rs2633083 chr11:47249420 T/C cg25783544 chr11:47291846 MADD -0.42 -7.92 -0.3 1.09e-14 Proinsulin levels; BRCA cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs6942756 0.806 rs2718096 chr7:128951000 A/G cg02491457 chr7:128862824 NA 0.56 12.05 0.43 2.92e-30 White matter hyperintensity burden; BRCA cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1215050 0.740 rs783941 chr4:99008235 T/C cg05340658 chr4:99064831 C4orf37 -0.48 -11.15 -0.4 1.67e-26 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.546 rs10025064 chr4:98914060 A/G cg05340658 chr4:99064831 C4orf37 0.56 11.14 0.4 1.86e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs10089 0.904 rs3087889 chr5:127524944 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 12.67 0.45 5.85e-33 Ileal carcinoids; BRCA trans rs78049276 0.688 rs56024659 chr4:148378604 C/T cg13149281 chr14:23389818 RBM23;PRMT5 -0.47 -8.47 -0.32 1.65e-16 Pulse pressure; BRCA cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg26647111 chr11:31128758 NA -0.44 -9.58 -0.35 2.07e-20 Red blood cell count; BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg05863683 chr7:1912471 MAD1L1 -0.37 -8.16 -0.31 1.83e-15 Bipolar disorder and schizophrenia; BRCA cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg00173435 chr12:106696525 TCP11L2 -0.55 -9.71 -0.36 7.11e-21 Tourette syndrome; BRCA cis rs10751667 0.560 rs10902267 chr11:1007831 T/C cg20946044 chr11:1010712 AP2A2 -0.37 -7.95 -0.3 8.63e-15 Alzheimer's disease (late onset); BRCA cis rs1005277 0.579 rs1780136 chr10:38501453 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.12 -0.58 1.55e-59 Extrinsic epigenetic age acceleration; BRCA cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg06221963 chr1:154839813 KCNN3 -0.56 -15.63 -0.53 7.06e-47 Prostate cancer; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.62 9.95 0.37 8.65e-22 Renal function-related traits (BUN); BRCA trans rs4714291 0.963 rs12194361 chr6:40116264 T/G cg02267698 chr19:7991119 CTXN1 -0.42 -8.14 -0.31 2.03e-15 Strep throat; BRCA cis rs7903847 0.620 rs11189165 chr10:99123457 A/G cg08345082 chr10:99160200 RRP12 -0.28 -8.04 -0.3 4.38e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs7412746 0.658 rs11204739 chr1:150865760 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.94 0.3 9.17e-15 Melanoma; BRCA cis rs4595586 0.545 rs61939641 chr12:39378001 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs3845702 0.673 rs12468986 chr2:180862320 T/G cg01881094 chr2:180872142 CWC22 1.01 17.22 0.56 6.97e-55 Schizophrenia; BRCA cis rs2637266 0.935 rs2579775 chr10:78401677 G/A cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA trans rs7647973 0.626 rs4855846 chr3:49683526 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.81 -0.3 2.3e-14 Menarche (age at onset); BRCA cis rs8114671 0.804 rs6060139 chr20:33566499 T/C cg24642439 chr20:33292090 TP53INP2 0.42 8.44 0.32 2.13e-16 Height; BRCA cis rs1832871 0.655 rs6920121 chr6:158678504 C/T cg07165851 chr6:158734300 TULP4 -0.62 -12.74 -0.45 2.62e-33 Height; BRCA cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg08000102 chr2:233561755 GIGYF2 0.63 13.78 0.48 4.93e-38 Coronary artery disease; BRCA cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 2.03e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs62458065 0.640 rs10271491 chr7:32530665 C/A cg20159608 chr7:32802032 NA -0.45 -8.2 -0.31 1.37e-15 Metabolite levels (HVA/MHPG ratio); BRCA cis rs11252926 0.565 rs4881308 chr10:484983 G/T cg18196295 chr10:418757 DIP2C 0.4 9.18 0.34 6.02e-19 Psychosis in Alzheimer's disease; BRCA cis rs12545109 0.800 rs1437278 chr8:57357024 T/C cg09654669 chr8:57350985 NA -0.43 -8.11 -0.31 2.64e-15 Obesity-related traits; BRCA trans rs7615952 0.932 rs13325495 chr3:125637416 T/G cg07211511 chr3:129823064 LOC729375 -1.05 -18.49 -0.59 1.78e-61 Blood pressure (smoking interaction); BRCA cis rs7647973 0.588 rs9883000 chr3:49667691 A/G cg03060546 chr3:49711283 APEH 0.58 10.07 0.37 2.95e-22 Menarche (age at onset); BRCA cis rs2204008 0.743 rs11495614 chr12:38156358 C/T cg26384229 chr12:38710491 ALG10B 0.73 15.58 0.52 1.26e-46 Bladder cancer; BRCA cis rs67981189 0.896 rs917065 chr14:71397846 G/A cg15816911 chr14:71606274 NA -0.37 -8.23 -0.31 1.04e-15 Schizophrenia; BRCA cis rs7572733 0.534 rs1589162 chr2:198782692 A/G cg00792783 chr2:198669748 PLCL1 0.46 9.87 0.36 1.82e-21 Dermatomyositis; BRCA cis rs6782228 0.675 rs4443194 chr3:128383446 T/A cg16766828 chr3:128327626 NA -0.44 -9.67 -0.36 9.88e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs12497850 0.931 rs7643368 chr3:48992855 T/G cg07636037 chr3:49044803 WDR6 0.97 29.54 0.76 1.35e-121 Parkinson's disease; BRCA trans rs6461049 0.800 rs2398706 chr7:2156338 A/T cg04565464 chr8:145669602 NFKBIL2 0.45 10.76 0.39 6.42e-25 Schizophrenia; BRCA cis rs7127129 0.503 rs1131715 chr11:70053487 C/T cg06159181 chr11:70072977 NA -0.32 -7.84 -0.3 1.83e-14 Aortic root size; BRCA cis rs1797081 0.967 rs780632 chr10:16861400 A/G cg23933602 chr10:16859644 RSU1 -0.97 -32.14 -0.79 1.42e-135 Platelet distribution width; BRCA cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg18357526 chr6:26021779 HIST1H4A 0.47 8.72 0.33 2.35e-17 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.41 -0.32 2.72e-16 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg26314531 chr2:26401878 FAM59B 0.69 11.55 0.42 3.74e-28 Gut microbiome composition (summer); BRCA cis rs2749592 0.611 rs176888 chr10:38406161 C/A cg25427524 chr10:38739819 LOC399744 -0.66 -13.56 -0.47 5.38e-37 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs10771431 1.000 rs11611670 chr12:9385535 C/T cg27600084 chr12:12264075 NA 0.39 8.82 0.33 1.05e-17 Breast size; BRCA cis rs4566357 0.595 rs1320406 chr2:227920474 C/T cg05526886 chr2:227700861 RHBDD1 -0.39 -7.9 -0.3 1.25e-14 Coronary artery disease; BRCA cis rs713587 0.563 rs7591460 chr2:25103967 A/C cg04586622 chr2:25135609 ADCY3 0.45 11.54 0.42 4.22e-28 Body mass index in non-asthmatics; BRCA cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg21918786 chr6:109611834 NA -0.49 -14.04 -0.49 3.1e-39 Reticulocyte fraction of red cells; BRCA cis rs4728302 0.608 rs10254118 chr7:133158353 T/A cg10665199 chr7:133106180 EXOC4 0.47 10.09 0.37 2.51e-22 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.66e-77 Mean platelet volume; BRCA cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg22535103 chr8:58192502 C8orf71 -0.44 -8.87 -0.33 7.16e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1335641 chr6:8487860 G/T cg07606381 chr6:8435919 SLC35B3 0.65 14.49 0.5 2.37e-41 Motion sickness; BRCA cis rs10751667 0.643 rs7395613 chr11:933873 C/T cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.49e-34 Alzheimer's disease (late onset); BRCA cis rs10911232 0.507 rs10797833 chr1:183044067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.33 0.54 2.37e-50 Hypertriglyceridemia; BRCA cis rs1577917 0.740 rs9344542 chr6:86393905 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.33 9.25 0.34 3.24e-19 Response to antipsychotic treatment; BRCA cis rs427394 0.659 rs274674 chr5:6755460 C/T cg10857441 chr5:6722123 POLS -0.31 -9.76 -0.36 4.63e-21 Menopause (age at onset); BRCA trans rs4819388 0.650 rs8127114 chr21:45644504 T/C cg17383793 chr5:52405638 MOCS2 0.48 10.65 0.39 1.7e-24 Celiac disease; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg15242686 chr22:24348715 GSTTP1 0.37 9.01 0.34 2.27e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.62 14.35 0.49 1.09e-40 Platelet count; BRCA cis rs2576037 0.526 rs2576051 chr18:44557884 G/A cg19077165 chr18:44547161 KATNAL2 0.54 11.71 0.42 7.7e-29 Personality dimensions; BRCA cis rs6142102 0.602 rs4911402 chr20:32667645 A/G cg24642439 chr20:33292090 TP53INP2 0.39 7.82 0.3 2.24e-14 Skin pigmentation; BRCA trans rs28735056 0.903 rs56185453 chr18:77638297 A/G cg05926928 chr17:57297772 GDPD1 -0.52 -10.55 -0.39 4.12e-24 Schizophrenia; BRCA cis rs1451375 0.669 rs4469404 chr7:50647062 C/T cg18232548 chr7:50535776 DDC -0.38 -8.75 -0.33 1.87e-17 Malaria; BRCA cis rs6484504 0.600 rs2616815 chr11:31327316 C/T cg26647111 chr11:31128758 NA 0.45 9.65 0.36 1.18e-20 Red blood cell count; BRCA trans rs2018683 0.624 rs1006521 chr7:28996220 G/A cg19402173 chr7:128379420 CALU -0.47 -11.2 -0.41 9.97e-27 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs9291683 0.609 rs13141233 chr4:10028729 T/C cg00071950 chr4:10020882 SLC2A9 0.65 16.24 0.54 6.46e-50 Bone mineral density; BRCA cis rs2180341 1.000 rs6904520 chr6:127629802 T/C cg24812749 chr6:127587940 RNF146 0.89 20.97 0.64 1.08e-74 Breast cancer; BRCA cis rs427394 0.796 rs274683 chr5:6747950 T/A cg10857441 chr5:6722123 POLS -0.29 -9.36 -0.35 1.32e-19 Menopause (age at onset); BRCA cis rs9457247 0.534 rs933243 chr6:167403873 A/C cg23791538 chr6:167370224 RNASET2 -0.48 -11.84 -0.42 2.13e-29 Crohn's disease; BRCA cis rs7586879 0.828 rs10195271 chr2:25108650 A/C cg04586622 chr2:25135609 ADCY3 -0.4 -9.59 -0.35 1.9e-20 Body mass index; BRCA cis rs10227331 0.617 rs55977076 chr7:157301739 A/G cg04156418 chr7:157293606 NA 0.32 9.06 0.34 1.51e-18 Inattentive symptoms; BRCA cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg09877947 chr5:131593287 PDLIM4 -0.37 -8.11 -0.31 2.51e-15 Breast cancer; BRCA cis rs877529 1.000 rs139388 chr22:39531732 C/G cg12193277 chr22:39547181 CBX7 0.46 12.76 0.45 2.24e-33 Multiple myeloma; BRCA cis rs870825 0.616 rs41278579 chr4:185622402 A/G cg04058563 chr4:185651563 MLF1IP 0.86 16.4 0.54 1.05e-50 Blood protein levels; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg14820908 chr5:178986412 RUFY1 0.5 13.33 0.47 5.9e-36 Lung cancer; BRCA cis rs360798 0.512 rs34104251 chr2:62995183 A/G cg17519650 chr2:63277830 OTX1 -0.36 -7.95 -0.3 8.79e-15 Coronary artery disease; BRCA cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 14.81 0.51 7.16e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3771570 0.901 rs4675944 chr2:242430170 C/T cg21155796 chr2:242212141 HDLBP 0.53 8.74 0.33 2.04e-17 Prostate cancer; BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.45 9.26 0.34 3.05e-19 Tonsillectomy; BRCA cis rs6878727 0.626 rs183164 chr5:123670448 A/G cg01806427 chr5:123737813 NA -0.37 -8.43 -0.32 2.21e-16 Breast cancer; BRCA trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.71 -0.33 2.55e-17 Extrinsic epigenetic age acceleration; BRCA cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg19077165 chr18:44547161 KATNAL2 -0.53 -11.59 -0.42 2.6e-28 Personality dimensions; BRCA cis rs2267137 0.903 rs715494 chr22:29782433 G/T cg07256473 chr22:29710276 RASL10A -0.34 -8.14 -0.31 2.12e-15 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7647973 0.626 rs12715437 chr3:49751856 T/C cg03060546 chr3:49711283 APEH 0.59 10.23 0.37 7.84e-23 Menarche (age at onset); BRCA cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg06550200 chr5:1325588 CLPTM1L -0.62 -13.09 -0.46 7.81e-35 Lung cancer; BRCA cis rs7616215 0.519 rs2133664 chr3:46101774 T/A cg08033130 chr3:45983597 CXCR6;FYCO1 0.3 8.03 0.3 4.63e-15 Behcet's disease; BRCA cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs13256369 1.000 rs13267501 chr8:8574058 G/A cg17143192 chr8:8559678 CLDN23 0.52 10.05 0.37 3.82e-22 Obesity-related traits; BRCA cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06544989 chr22:39130855 UNC84B 0.35 7.98 0.3 6.85e-15 Menopause (age at onset); BRCA cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.21 0.31 1.24e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 12.33 0.44 1.81e-31 Platelet count; BRCA cis rs35110281 0.782 rs7282933 chr21:45046988 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.42 -0.35 8.28e-20 Mean corpuscular volume; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.6 -0.35 1.82e-20 Alzheimer's disease; BRCA cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg11764359 chr7:65958608 NA 0.74 16.0 0.53 1.01e-48 Aortic root size; BRCA cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg05283184 chr6:79620031 NA -0.43 -10.91 -0.4 1.56e-25 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.686 rs857883 chr6:145969214 G/T cg23711669 chr6:146136114 FBXO30 -0.78 -18.65 -0.59 2.56e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg06558623 chr16:89946397 TCF25 0.65 11.86 0.42 1.76e-29 Skin colour saturation; BRCA cis rs3845702 0.736 rs72962575 chr2:180862133 C/G cg01881094 chr2:180872142 CWC22 1.01 17.22 0.56 6.97e-55 Schizophrenia; BRCA cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg13010199 chr12:38710504 ALG10B 0.52 10.88 0.4 2.06e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs67311347 0.955 rs6764102 chr3:40378153 C/G cg09455208 chr3:40491958 NA 0.4 9.57 0.35 2.32e-20 Renal cell carcinoma; BRCA cis rs1372520 0.684 rs1442148 chr4:90748846 T/A cg15133208 chr4:90757351 SNCA -0.38 -7.85 -0.3 1.73e-14 Neuroticism; BRCA cis rs11711311 1.000 rs10212375 chr3:113471336 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.34 0.35 1.58e-19 IgG glycosylation; BRCA cis rs4595586 0.545 rs3911798 chr12:39389901 A/G cg26384229 chr12:38710491 ALG10B 0.43 9.53 0.35 3.15e-20 Morning vs. evening chronotype; BRCA cis rs8005677 1.000 rs1956880 chr14:23394007 A/G cg01529538 chr14:23388837 RBM23 0.42 11.39 0.41 1.73e-27 Cognitive ability (multi-trait analysis); BRCA cis rs7582720 1.000 rs72936332 chr2:204056678 T/C cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.22 0.44 5.16e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg23708337 chr7:1209742 NA 0.6 8.29 0.31 6.64e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6754311 0.731 rs1470457 chr2:136581848 A/G cg15123519 chr2:136567270 LCT -0.32 -8.0 -0.3 5.69e-15 Mosquito bite size; BRCA cis rs4819052 0.851 rs2838864 chr21:46711474 A/T cg02159808 chr21:46707872 POFUT2;LOC642852 -0.46 -8.69 -0.33 3.03e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg13010199 chr12:38710504 ALG10B 0.59 12.95 0.46 3.28e-34 Heart rate; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg15112475 chr7:1198522 ZFAND2A -0.52 -11.78 -0.42 3.89e-29 Longevity;Endometriosis; BRCA cis rs6088590 0.965 rs6087639 chr20:33443866 G/A cg08999081 chr20:33150536 PIGU 0.35 8.92 0.33 5.02e-18 Coronary artery disease; BRCA cis rs965469 0.619 rs6037565 chr20:3330308 T/C cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA cis rs9733 0.596 rs12086472 chr1:150697710 G/A cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs1448094 0.512 rs10779216 chr12:86240315 A/G cg19622623 chr12:86230825 RASSF9 0.33 9.44 0.35 6.68e-20 Major depressive disorder; BRCA cis rs897984 0.553 rs2335013 chr16:30877346 T/G cg02466173 chr16:30829666 NA 0.45 9.19 0.34 5.24e-19 Dementia with Lewy bodies; BRCA cis rs10883723 0.773 rs2296578 chr10:104240974 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.25 0.61 1.87e-65 Allergic disease (asthma, hay fever or eczema); BRCA cis rs11190604 0.767 rs10883477 chr10:102161396 A/G cg07080220 chr10:102295463 HIF1AN 0.49 10.65 0.39 1.7e-24 Palmitoleic acid (16:1n-7) levels; BRCA trans rs4718428 0.705 rs4718424 chr7:66376095 G/A cg18876405 chr7:65276391 NA 0.44 8.58 0.32 7.45e-17 Corneal structure; BRCA cis rs698833 0.561 rs698820 chr2:44716323 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.44 8.17 0.31 1.62e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7103648 0.897 rs3758675 chr11:47400602 G/A cg20307385 chr11:47447363 PSMC3 0.83 20.76 0.63 1.48e-73 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs4481887 0.927 rs12731721 chr1:248474210 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.18 0.43 7.6e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7633770 0.735 rs4683271 chr3:46684823 A/G cg11219411 chr3:46661640 NA -0.56 -13.39 -0.47 3.32e-36 Coronary artery disease; BRCA cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg14784868 chr12:69753453 YEATS4 0.68 19.91 0.62 5.54e-69 Blood protein levels; BRCA cis rs7572733 0.534 rs1983359 chr2:198805098 C/T cg00792783 chr2:198669748 PLCL1 0.45 9.94 0.37 9.5e-22 Dermatomyositis; BRCA cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg20203395 chr5:56204925 C5orf35 -0.49 -9.91 -0.36 1.25e-21 Initial pursuit acceleration; BRCA cis rs589448 0.902 rs2603089 chr12:69776800 C/T cg22834771 chr12:69754056 YEATS4 0.39 9.88 0.36 1.63e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs453301 0.686 rs6601280 chr8:8909236 A/T cg15556689 chr8:8085844 FLJ10661 0.36 9.54 0.35 2.83e-20 Joint mobility (Beighton score); BRCA cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.23e-36 Developmental language disorder (linguistic errors); BRCA cis rs9796 0.621 rs28737302 chr15:41469943 G/A cg18705301 chr15:41695430 NDUFAF1 -0.36 -7.84 -0.3 1.89e-14 Menopause (age at onset); BRCA cis rs7246657 0.943 rs3760825 chr19:37945601 C/T cg14683738 chr19:37701593 ZNF585B 0.44 7.9 0.3 1.22e-14 Coronary artery calcification; BRCA cis rs3768617 0.510 rs3768622 chr1:183090011 G/A ch.1.3577855R chr1:183094577 LAMC1 0.62 16.11 0.54 2.99e-49 Fuchs's corneal dystrophy; BRCA cis rs4919694 1.000 rs35159404 chr10:104805610 C/A cg04362960 chr10:104952993 NT5C2 0.94 14.4 0.5 6.33e-41 Arsenic metabolism; BRCA cis rs2479724 0.846 rs2488338 chr6:41808351 A/G cg17623882 chr6:41773611 USP49 -0.34 -9.17 -0.34 6.64e-19 Menarche (age at onset); BRCA trans rs8002861 0.935 rs1819595 chr13:44429716 T/A cg17145862 chr1:211918768 LPGAT1 0.68 17.84 0.58 4.56e-58 Leprosy; BRCA cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg18404041 chr3:52824283 ITIH1 -0.43 -12.98 -0.46 2.29e-34 Bipolar disorder; BRCA cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg24549020 chr5:56110836 MAP3K1 0.6 12.27 0.44 3.19e-31 Initial pursuit acceleration; BRCA cis rs4481887 1.000 rs7517319 chr1:248466408 C/A cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.79e-18 Common traits (Other); BRCA cis rs78456975 1.000 rs13416881 chr2:1554808 G/A cg12573674 chr2:1569213 NA -0.5 -9.47 -0.35 5.24e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10911251 0.546 rs2027084 chr1:183110801 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.6e-51 Colorectal cancer; BRCA cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg25358565 chr5:93447407 FAM172A 1.17 18.51 0.59 1.49e-61 Diabetic retinopathy; BRCA cis rs3845702 1.000 rs3768839 chr2:180835992 G/A cg01881094 chr2:180872142 CWC22 -0.66 -12.6 -0.45 1.17e-32 Schizophrenia; BRCA cis rs1878931 0.582 rs40633 chr16:3425325 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -9.69 -0.36 8.18e-21 Body mass index (adult); BRCA cis rs2439831 0.850 rs9944216 chr15:44160773 C/G cg02155558 chr15:43621948 ADAL;LCMT2 -0.68 -12.11 -0.43 1.6e-30 Lung cancer in ever smokers; BRCA cis rs2795502 1.000 rs2473119 chr10:43339038 A/T cg20628663 chr10:43360327 NA -0.7 -13.59 -0.47 4.08e-37 Blood protein levels; BRCA cis rs9467773 0.967 rs6941022 chr6:26553531 T/C cg09904177 chr6:26538194 HMGN4 0.55 17.67 0.57 3.26e-57 Intelligence (multi-trait analysis); BRCA cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg08085267 chr17:45401833 C17orf57 0.57 11.76 0.42 4.79e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4319547 0.656 rs2173582 chr12:122824694 A/G cg23029597 chr12:123009494 RSRC2 -0.6 -11.54 -0.42 4.25e-28 Body mass index; BRCA cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg04034577 chr2:241836375 C2orf54 -0.57 -14.0 -0.48 4.88e-39 Urinary metabolites; BRCA trans rs7819412 0.561 rs2001328 chr8:10987199 T/C cg15556689 chr8:8085844 FLJ10661 -0.33 -8.42 -0.32 2.39e-16 Triglycerides; BRCA cis rs7945718 0.806 rs7480572 chr11:12787048 T/C cg25843174 chr11:12811716 TEAD1 0.23 9.06 0.34 1.6e-18 Educational attainment (years of education); BRCA cis rs11252926 0.527 rs10904093 chr10:436848 A/G cg16386425 chr10:429943 DIP2C 0.42 8.35 0.31 4.21e-16 Psychosis in Alzheimer's disease; BRCA cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 26.42 0.72 1.58e-104 Chronic sinus infection; BRCA cis rs6831352 0.918 rs7670060 chr4:100059568 G/T cg13256891 chr4:100009986 ADH5 -0.53 -9.87 -0.36 1.82e-21 Alcohol dependence; BRCA cis rs6831352 0.840 rs35073321 chr4:100053276 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs9942416 0.660 rs4704231 chr5:74986576 G/A cg19683494 chr5:74908142 NA 0.48 9.0 0.34 2.47e-18 Age-related disease endophenotypes; BRCA cis rs12410462 1.000 rs16847833 chr1:227626662 G/A cg23173402 chr1:227635558 NA 0.5 9.18 0.34 5.68e-19 Major depressive disorder; BRCA cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg24578937 chr1:2090814 PRKCZ 0.33 10.48 0.38 7.83e-24 Height; BRCA cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg13119609 chr19:45449297 APOC2 0.47 13.08 0.46 8.51e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg12444411 chr7:2802554 GNA12 -0.36 -8.98 -0.33 2.9e-18 Height; BRCA cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6684428 1.000 rs12141666 chr1:56370556 T/C cg11651538 chr1:56320950 NA -0.46 -7.81 -0.3 2.32e-14 Airflow obstruction; BRCA cis rs6977660 0.714 rs4719587 chr7:19828174 C/G cg05791153 chr7:19748676 TWISTNB 0.54 10.12 0.37 2.02e-22 Thyroid stimulating hormone; BRCA cis rs698833 0.828 rs1067341 chr2:44623687 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.47 0.35 5.17e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs17270561 0.609 rs7770037 chr6:25760591 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs4742903 1.000 rs7350148 chr9:106883085 T/G cg21169611 chr9:106856078 SMC2 0.35 9.08 0.34 1.29e-18 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs9457247 0.508 rs6941355 chr6:167506238 A/G cg07741184 chr6:167504864 NA 0.31 9.33 0.35 1.73e-19 Crohn's disease; BRCA cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg02017074 chr12:117425053 FBXW8 0.55 10.24 0.38 7.15e-23 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.92 14.07 0.49 2.34e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg06085985 chr11:830527 EFCAB4A -0.41 -9.24 -0.34 3.48e-19 Mean platelet volume; BRCA cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg18225595 chr11:63971243 STIP1 0.51 9.46 0.35 5.83e-20 Mean platelet volume; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg03188948 chr7:1209495 NA 0.45 8.3 0.31 6.08e-16 Longevity;Endometriosis; BRCA cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg01017244 chr2:74357527 NA 0.57 13.23 0.46 1.78e-35 Gestational age at birth (maternal effect); BRCA trans rs6951245 0.608 rs10252234 chr7:1114381 C/T cg13565492 chr6:43139072 SRF -0.56 -10.06 -0.37 3.24e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs617791 0.530 rs7934543 chr11:65752508 G/T cg17712092 chr4:129076599 LARP1B -0.5 -10.89 -0.4 1.83e-25 Breast cancer; BRCA cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg19077165 chr18:44547161 KATNAL2 -0.58 -12.87 -0.45 7e-34 Personality dimensions; BRCA cis rs11025559 0.796 rs11603462 chr11:20412180 C/A cg19653624 chr11:20408972 PRMT3 -0.44 -10.13 -0.37 1.83e-22 Pursuit maintenance gain; BRCA cis rs2832191 0.791 rs7283853 chr21:30498515 G/A cg24692254 chr21:30365293 RNF160 -0.62 -15.86 -0.53 5.2e-48 Dental caries; BRCA cis rs17270561 0.609 rs4711100 chr6:25741954 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA trans rs35110281 0.720 rs162374 chr21:44927089 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -10.12 -0.37 1.93e-22 Mean corpuscular volume; BRCA cis rs7077164 1.000 rs1227769 chr10:71586296 C/T cg07630274 chr10:71583235 COL13A1 -0.25 -8.06 -0.3 3.72e-15 Non-alcoholic fatty liver disease histology (lobular); BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs9790314 0.936 rs466399 chr3:161091194 G/T cg03342759 chr3:160939853 NMD3 -0.53 -11.24 -0.41 7.01e-27 Morning vs. evening chronotype; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.13 -0.34 8.58e-19 Total body bone mineral density; BRCA trans rs1973993 0.934 rs588660 chr1:96886604 G/A cg10631902 chr5:14652156 NA 0.51 15.88 0.53 4.3e-48 Weight; BRCA cis rs10992471 0.528 rs10992347 chr9:95220633 C/A cg14631576 chr9:95140430 CENPP -0.35 -8.85 -0.33 8.49e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs8017423 1.000 rs769044 chr14:90671138 A/G cg04374321 chr14:90722782 PSMC1 0.71 18.69 0.59 1.6e-62 Mortality in heart failure; BRCA cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs11190604 1.000 rs10786596 chr10:102282126 C/A cg07080220 chr10:102295463 HIF1AN 0.56 13.14 0.46 4.42e-35 Palmitoleic acid (16:1n-7) levels; BRCA trans rs6582630 0.555 rs10880624 chr12:38526316 C/T cg06521331 chr12:34319734 NA -0.47 -8.75 -0.33 1.86e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs9341808 0.690 rs9448909 chr6:80909031 G/A cg08355045 chr6:80787529 NA 0.39 9.95 0.37 8.61e-22 Sitting height ratio; BRCA cis rs3771570 1.000 rs62193205 chr2:242316512 C/T cg21155796 chr2:242212141 HDLBP 0.6 9.2 0.34 5.1e-19 Prostate cancer; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg23978390 chr7:1156363 C7orf50 0.48 11.54 0.42 4.16e-28 Longevity;Endometriosis; BRCA cis rs9290065 0.519 rs6763532 chr3:160701816 G/A cg03342759 chr3:160939853 NMD3 -0.49 -9.95 -0.37 9.17e-22 Kawasaki disease; BRCA cis rs7524258 0.903 rs4908449 chr1:7292700 T/C cg07173049 chr1:7289937 CAMTA1 0.55 13.56 0.47 5.59e-37 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs698833 0.886 rs2304770 chr2:44569328 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.55 11.41 0.41 1.37e-27 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.49 -0.44 3.53e-32 Developmental language disorder (linguistic errors); BRCA cis rs10465746 0.725 rs4907185 chr1:84336047 T/C cg10977910 chr1:84465055 TTLL7 0.61 13.16 0.46 3.51e-35 Obesity-related traits; BRCA cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg23033748 chr14:75592666 NEK9 0.44 10.51 0.38 5.92e-24 Height; BRCA cis rs1003719 0.715 rs35199609 chr21:38510262 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.3e-40 Eye color traits; BRCA cis rs698833 0.892 rs698831 chr2:44731117 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.61 0.36 1.63e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs3768617 0.510 rs7549768 chr1:183097382 T/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.13 0.56 2.16e-54 Fuchs's corneal dystrophy; BRCA cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg01262667 chr19:19385393 TM6SF2 0.42 11.18 0.4 1.31e-26 Tonsillectomy; BRCA cis rs16866061 1.000 rs11688397 chr2:225393173 C/T cg12698349 chr2:225449008 CUL3 0.78 21.23 0.64 4.3e-76 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg25036284 chr2:26402008 FAM59B -0.64 -10.67 -0.39 1.39e-24 Gut microbiome composition (summer); BRCA cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg27129171 chr3:47204927 SETD2 0.65 14.27 0.49 2.61e-40 Birth weight; BRCA cis rs897080 0.552 rs1067388 chr2:44642482 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.45 0.35 6.32e-20 Height; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -9.13 -0.34 8.95e-19 Total body bone mineral density; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs2742417 0.603 rs2673032 chr3:45756927 C/T cg04837898 chr3:45731254 SACM1L -0.4 -8.15 -0.31 1.87e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs3892630 0.878 rs8112955 chr19:33191192 C/T cg22980127 chr19:33182716 NUDT19 0.9 18.06 0.58 3.08e-59 Red blood cell traits; BRCA cis rs9341808 1.000 rs1359239 chr6:80956146 G/A cg08355045 chr6:80787529 NA 0.35 9.21 0.34 4.55e-19 Sitting height ratio; BRCA cis rs7666738 0.830 rs62318471 chr4:98925848 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.42e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.9 0.36 1.36e-21 Bipolar disorder; BRCA cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.45 0.35 6.39e-20 Motion sickness; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg16606324 chr3:10149918 C3orf24 0.58 10.26 0.38 5.81e-23 Alzheimer's disease; BRCA cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg00106254 chr7:1943704 MAD1L1 -0.34 -8.45 -0.32 2.01e-16 Bipolar disorder and schizophrenia; BRCA cis rs11711311 1.000 rs4362695 chr3:113534856 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.44 0.32 2.16e-16 IgG glycosylation; BRCA cis rs9533799 0.966 rs7999368 chr13:44807184 G/A cg19190762 chr13:44806055 NA 0.41 9.02 0.34 2.17e-18 Amyotrophic lateral sclerosis; BRCA cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg16405210 chr4:1374714 KIAA1530 0.36 8.01 0.3 5.34e-15 Obesity-related traits; BRCA cis rs2764980 1.000 rs2814925 chr10:3284061 A/G cg18054281 chr10:3284093 NA -0.31 -7.89 -0.3 1.33e-14 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs780096 0.546 rs2293572 chr2:27728777 C/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 0.31 8.0 0.3 6e-15 Total body bone mineral density; BRCA cis rs875971 0.522 rs4502988 chr7:65297746 A/G cg11764359 chr7:65958608 NA 0.62 13.59 0.47 4.03e-37 Aortic root size; BRCA cis rs7043114 0.507 rs6479420 chr9:95116406 T/C cg14631576 chr9:95140430 CENPP -0.34 -8.29 -0.31 6.8e-16 Height; BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg08742575 chr21:47604166 C21orf56 0.39 7.88 0.3 1.4e-14 Testicular germ cell tumor; BRCA cis rs965469 0.779 rs6037515 chr20:3233091 C/A cg25506879 chr20:3388711 C20orf194 -0.43 -8.68 -0.32 3.38e-17 IFN-related cytopenia; BRCA cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -9.96 -0.37 8.41e-22 Personality dimensions; BRCA trans rs1005277 0.579 rs1740745 chr10:38520056 T/C cg23533926 chr12:111358616 MYL2 -0.44 -9.18 -0.34 5.78e-19 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg08917208 chr2:24149416 ATAD2B 0.56 8.64 0.32 4.38e-17 Lymphocyte counts; BRCA trans rs3733585 0.648 rs7376155 chr4:9952588 C/T cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2.06e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7786877 0.680 rs28584500 chr7:100216341 G/A cg20848291 chr7:100343083 ZAN -0.59 -11.31 -0.41 3.79e-27 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7833986 0.501 rs2976038 chr8:57028864 G/A cg26371346 chr8:56986568 SNORD54;RPS20 0.47 7.95 0.3 8.55e-15 Height; BRCA cis rs4689388 0.853 rs4293850 chr4:6292020 A/C cg25554036 chr4:6271136 WFS1 0.39 9.3 0.35 2.22e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.586 rs1811483 chr3:161130900 A/G cg03342759 chr3:160939853 NMD3 -0.67 -14.7 -0.5 2.31e-42 Morning vs. evening chronotype; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg08132940 chr7:1081526 C7orf50 -0.6 -8.99 -0.34 2.69e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7552404 0.656 rs11161792 chr1:76336746 C/T cg03433033 chr1:76189801 ACADM 0.71 13.81 0.48 3.58e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs743757 0.762 rs12491425 chr3:50575312 A/G cg08207895 chr3:50388901 TUSC4;CYB561D2 -0.34 -8.08 -0.3 3.18e-15 Diastolic blood pressure; BRCA cis rs12618769 0.597 rs4850876 chr2:99112069 C/T cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs4948102 0.642 rs4948104 chr7:56142519 A/G cg09872392 chr7:56161020 PHKG1 -0.5 -12.53 -0.44 2.34e-32 Plasma homocysteine levels (post-methionine load test); BRCA cis rs1008375 1.000 rs62295634 chr4:17685346 C/A cg16339924 chr4:17578868 LAP3 0.6 14.48 0.5 2.65e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2554380 0.943 rs2585049 chr15:84352873 A/C cg14598478 chr15:84363061 ADAMTSL3 0.32 8.1 0.31 2.7e-15 Height; BRCA cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg07395648 chr5:131743802 NA -0.36 -7.99 -0.3 6.09e-15 Breast cancer; BRCA cis rs10876993 0.821 rs1678522 chr12:58049923 G/A cg00677455 chr12:58241039 CTDSP2 -0.35 -7.96 -0.3 7.8e-15 Celiac disease or Rheumatoid arthritis; BRCA cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg07636037 chr3:49044803 WDR6 0.97 29.45 0.76 4.14e-121 Parkinson's disease; BRCA cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg04607235 chr12:12878440 APOLD1 -0.56 -8.96 -0.33 3.42e-18 Systemic lupus erythematosus; BRCA cis rs9487051 0.735 rs351756 chr6:109538773 A/G cg01475377 chr6:109611718 NA 0.45 11.18 0.4 1.22e-26 Reticulocyte fraction of red cells; BRCA cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.49 -0.44 3.46e-32 Bipolar disorder; BRCA cis rs6840360 0.533 rs13119490 chr4:152713412 A/G cg22705602 chr4:152727874 NA 0.4 10.57 0.39 3.45e-24 Intelligence (multi-trait analysis); BRCA cis rs365132 0.875 rs353496 chr5:176429898 T/C cg16309518 chr5:176445507 NA -0.4 -9.73 -0.36 5.73e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs6426558 0.537 rs2718193 chr1:227404672 C/G cg10327440 chr1:227177885 CDC42BPA 0.43 8.41 0.32 2.74e-16 Neutrophil percentage of white cells; BRCA cis rs666930 1.000 rs666930 chr1:120258970 A/G cg19096424 chr1:120255104 PHGDH 0.37 8.77 0.33 1.64e-17 Breast cancer; BRCA cis rs7512552 0.839 rs1260459 chr1:150348253 T/G cg15654264 chr1:150340011 RPRD2 0.38 8.44 0.32 2.06e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs8177253 0.665 rs6774822 chr3:133442012 G/T cg12373951 chr3:133503437 NA 0.33 7.9 0.3 1.21e-14 Iron status biomarkers; BRCA cis rs936229 0.705 rs936227 chr15:75131959 A/G cg14664628 chr15:75095509 CSK -0.59 -14.53 -0.5 1.59e-41 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs17270561 0.609 rs4711097 chr6:25732314 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.86 0.33 7.98e-18 Iron status biomarkers; BRCA cis rs55883249 0.957 rs62119431 chr2:9750461 G/A cg23886495 chr2:9695866 ADAM17 0.55 7.86 0.3 1.59e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg05283184 chr6:79620031 NA -0.36 -8.35 -0.31 4.12e-16 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs10052428 chr5:93476530 T/C cg25358565 chr5:93447407 FAM172A 1.2 19.24 0.61 2.01e-65 Diabetic retinopathy; BRCA cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg24531977 chr5:56204891 C5orf35 0.71 15.67 0.53 4.4e-47 Initial pursuit acceleration; BRCA cis rs1355223 0.506 rs1828299 chr11:34870418 T/C cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.38 -0.35 1.1e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs3768617 0.811 rs10911233 chr1:183052585 G/A ch.1.3577855R chr1:183094577 LAMC1 0.46 10.14 0.37 1.61e-22 Fuchs's corneal dystrophy; BRCA cis rs9896933 0.830 rs607544 chr17:80768760 C/G cg20578329 chr17:80767326 TBCD -0.57 -9.18 -0.34 6.04e-19 Bone mineral accretion in asthma (oral corticosteroid dose interaction); BRCA trans rs1997103 0.871 rs1997100 chr7:55399656 C/G cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.55e-18 Motion sickness; BRCA cis rs7258465 1.000 rs7252707 chr19:18612257 G/A cg01065977 chr19:18549689 ISYNA1 -0.28 -8.38 -0.31 3.3e-16 Breast cancer; BRCA trans rs6582630 0.555 rs2090785 chr12:38424342 G/A cg06521331 chr12:34319734 NA -0.46 -8.53 -0.32 1.08e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg04267008 chr7:1944627 MAD1L1 -0.6 -13.51 -0.47 8.94e-37 Bipolar disorder and schizophrenia; BRCA cis rs2289583 0.503 rs12050494 chr15:75260896 G/A cg10253484 chr15:75165896 SCAMP2 0.47 8.53 0.32 1.07e-16 Systemic lupus erythematosus; BRCA trans rs2204008 0.807 rs4123933 chr12:37973539 G/A cg06521331 chr12:34319734 NA -0.54 -9.66 -0.36 1.07e-20 Bladder cancer; BRCA cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.79 0.42 3.73e-29 Homoarginine levels; BRCA cis rs10267417 0.603 rs10233354 chr7:19895372 C/T cg07541023 chr7:19748670 TWISTNB 0.46 8.32 0.31 5.3e-16 Night sleep phenotypes; BRCA cis rs1371614 0.589 rs4665919 chr2:27115304 T/C cg12368169 chr2:27073192 DPYSL5 -0.29 -8.41 -0.32 2.61e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs514406 1.000 rs514406 chr1:53330458 A/G cg24675658 chr1:53192096 ZYG11B -0.56 -11.73 -0.42 6.35e-29 Monocyte count; BRCA cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg26408565 chr15:76604113 ETFA -0.36 -7.8 -0.3 2.44e-14 Blood metabolite levels; BRCA cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg06784218 chr1:46089804 CCDC17 0.46 10.93 0.4 1.34e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3771570 0.786 rs62186396 chr2:242221219 A/G cg21155796 chr2:242212141 HDLBP 0.62 9.75 0.36 4.91e-21 Prostate cancer; BRCA cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg20503657 chr10:835505 NA 0.9 13.79 0.48 4.67e-38 Eosinophil percentage of granulocytes; BRCA cis rs9811920 0.609 rs4244713 chr3:99679584 T/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.88 -0.3 1.42e-14 Axial length; BRCA trans rs57221529 0.713 rs12521091 chr5:590710 G/T cg11887960 chr12:57824829 NA 0.52 8.12 0.31 2.34e-15 Lung disease severity in cystic fibrosis; BRCA cis rs11249608 0.548 rs7707587 chr5:178462590 G/C cg21905437 chr5:178450457 ZNF879 0.51 10.64 0.39 1.95e-24 Pubertal anthropometrics; BRCA cis rs875971 0.862 rs35034167 chr7:65580166 C/G cg18876405 chr7:65276391 NA -0.51 -11.69 -0.42 9.89e-29 Aortic root size; BRCA trans rs8002861 0.810 rs9533664 chr13:44440527 T/C cg17145862 chr1:211918768 LPGAT1 0.63 16.32 0.54 2.68e-50 Leprosy; BRCA cis rs17490626 0.533 rs12771890 chr10:71189483 T/A cg12610070 chr10:71211762 TSPAN15 -0.33 -10.47 -0.38 8.7e-24 Thrombosis; BRCA cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg07606381 chr6:8435919 SLC35B3 0.66 14.38 0.49 8.22e-41 Motion sickness; BRCA cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg22800045 chr5:56110881 MAP3K1 -0.47 -9.34 -0.35 1.54e-19 Initial pursuit acceleration; BRCA cis rs8032158 0.963 rs11071231 chr15:56159118 A/C cg02198044 chr15:56286336 NEDD4 -0.37 -8.93 -0.33 4.47e-18 Keloid; BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.99 18.6 0.59 4.85e-62 Platelet count; BRCA cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14240646 chr10:27532245 ACBD5 -0.62 -9.58 -0.35 2.13e-20 Breast cancer; BRCA cis rs896854 0.715 rs12548874 chr8:95935164 A/C cg13393036 chr8:95962371 TP53INP1 0.31 8.33 0.31 5.05e-16 Type 2 diabetes; BRCA cis rs9633740 0.545 rs2343306 chr10:82230146 A/G cg01528321 chr10:82214614 TSPAN14 -1.09 -23.48 -0.68 2.22e-88 Post bronchodilator FEV1; BRCA cis rs13191362 0.688 rs73035006 chr6:162997083 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.36 0.44 1.23e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg11502198 chr6:26597334 ABT1 -0.54 -11.52 -0.41 4.99e-28 Intelligence (multi-trait analysis); BRCA cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 15.56 0.52 1.59e-46 Allergic disease (asthma, hay fever or eczema); BRCA cis rs477692 0.789 rs507900 chr10:131398144 A/G cg05714579 chr10:131428358 MGMT -0.52 -11.75 -0.42 5.53e-29 Response to temozolomide; BRCA cis rs1371867 0.846 rs1788206 chr8:101306966 A/G cg06636551 chr8:101224915 SPAG1 -0.38 -8.72 -0.33 2.39e-17 Atrioventricular conduction; BRCA cis rs9325144 0.560 rs10506125 chr12:39120287 C/T cg26384229 chr12:38710491 ALG10B 0.48 11.69 0.42 9.48e-29 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.6 0.55 9.67e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs6912958 0.712 rs2307379 chr6:88366771 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.87 -0.33 7.39e-18 Monocyte percentage of white cells; BRCA cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg19784903 chr17:45786737 TBKBP1 -0.35 -8.17 -0.31 1.62e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11190604 1.000 rs2495736 chr10:102338410 T/C cg07080220 chr10:102295463 HIF1AN 0.62 13.42 0.47 2.41e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.85 -14.92 -0.51 2.05e-43 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6582618 1 rs6582618 chr12:38726137 A/G cg26384229 chr12:38710491 ALG10B 0.46 11.66 0.42 1.3e-28 Morning vs. evening chronotype; BRCA cis rs4689388 0.816 rs13147655 chr4:6293474 A/G cg00701064 chr4:6280414 WFS1 0.68 17.7 0.57 2.54e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg02524346 chr8:600233 NA -0.78 -8.82 -0.33 1.09e-17 IgG glycosylation; BRCA cis rs4363385 0.818 rs3795382 chr1:153004853 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.59 -0.32 6.84e-17 Inflammatory skin disease; BRCA cis rs12545109 0.800 rs2609978 chr8:57394467 T/C cg09654669 chr8:57350985 NA -0.42 -8.03 -0.3 4.6e-15 Obesity-related traits; BRCA cis rs67460515 0.563 rs4521287 chr3:160812752 C/T cg03342759 chr3:160939853 NMD3 -0.7 -14.09 -0.49 1.85e-39 Parkinson's disease; BRCA cis rs765787 0.530 rs1706831 chr15:45516230 T/C cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs709400 0.628 rs12879085 chr14:103874420 G/A cg26031613 chr14:104095156 KLC1 -0.65 -14.04 -0.49 3.08e-39 Body mass index; BRCA cis rs765787 0.530 rs1706835 chr15:45517884 G/A cg15395560 chr15:45543142 SLC28A2 0.29 8.21 0.31 1.22e-15 Uric acid levels; BRCA cis rs425277 0.606 rs424079 chr1:2071340 C/A cg19257562 chr1:2043853 PRKCZ 0.36 9.87 0.36 1.73e-21 Height; BRCA trans rs2018683 0.834 rs733485 chr7:29026685 C/A cg19402173 chr7:128379420 CALU -0.49 -12.16 -0.43 9.52e-31 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs9859260 0.744 rs3933 chr3:195784997 C/T cg03462622 chr3:195777018 TFRC -0.39 -8.9 -0.33 5.87e-18 Mean corpuscular volume; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg00166722 chr3:10149974 C3orf24 0.65 12.78 0.45 1.74e-33 Alzheimer's disease; BRCA cis rs738322 0.600 rs6001030 chr22:38555904 T/G cg20207973 chr22:38506712 BAIAP2L2 0.35 8.48 0.32 1.59e-16 Cutaneous nevi; BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg00814883 chr7:100076585 TSC22D4 -0.54 -11.55 -0.42 3.66e-28 Platelet count; BRCA cis rs4919087 0.962 rs10748691 chr10:98983955 C/T cg25902810 chr10:99078978 FRAT1 0.41 8.77 0.33 1.68e-17 Monocyte count; BRCA cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg24562669 chr7:97807699 LMTK2 -0.52 -14.61 -0.5 6.13e-42 Breast cancer; BRCA cis rs7829975 0.567 rs6601273 chr8:8796519 T/G cg08975724 chr8:8085496 FLJ10661 -0.41 -8.8 -0.33 1.32e-17 Mood instability; BRCA cis rs16958440 0.867 rs28578518 chr18:44687548 A/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs72772090 0.539 rs11743410 chr5:96124453 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs679087 0.932 rs7312697 chr12:29933069 T/C cg14258853 chr12:29935411 TMTC1 0.35 8.05 0.3 3.96e-15 Schizophrenia; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg21143896 chr7:2802374 GNA12 -0.32 -8.12 -0.31 2.49e-15 Height; BRCA cis rs62380364 0.565 rs13158247 chr5:88030670 C/T cg22951263 chr5:87985283 NA -0.38 -10.62 -0.39 2.35e-24 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg20607798 chr8:58055168 NA 0.48 8.38 0.31 3.26e-16 Developmental language disorder (linguistic errors); BRCA cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg26248373 chr2:1572462 NA -0.63 -14.95 -0.51 1.49e-43 IgG glycosylation; BRCA trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg00717180 chr2:96193071 NA -0.31 -8.5 -0.32 1.32e-16 Coronary artery disease; BRCA cis rs6582630 0.519 rs4406888 chr12:38293312 A/C cg13010199 chr12:38710504 ALG10B 0.5 10.53 0.38 4.99e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs12142240 0.698 rs56909107 chr1:46808224 A/C cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg26384229 chr12:38710491 ALG10B 0.74 16.62 0.55 8.14e-52 Morning vs. evening chronotype; BRCA cis rs752010 1.000 rs2077172 chr1:42093340 A/G cg06885757 chr1:42089581 HIVEP3 0.27 9.66 0.36 1.11e-20 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7617773 0.709 rs4404473 chr3:48353626 A/G cg11946769 chr3:48343235 NME6 0.68 13.33 0.47 6.26e-36 Coronary artery disease; BRCA cis rs796364 0.762 rs13030712 chr2:200973569 G/A cg23649088 chr2:200775458 C2orf69 0.55 10.25 0.38 6.28e-23 Schizophrenia; BRCA cis rs208520 0.690 rs12202401 chr6:66760544 A/G cg07460842 chr6:66804631 NA 1.0 19.98 0.62 2.21e-69 Exhaled nitric oxide output; BRCA cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg23788917 chr6:8435910 SLC35B3 -0.43 -9.26 -0.34 2.96e-19 Motion sickness; BRCA cis rs2506889 0.553 rs11580264 chr1:10605796 C/A cg17425144 chr1:10567563 PEX14 0.57 14.19 0.49 6.61e-40 Breast cancer; BRCA trans rs208520 0.754 rs1100989 chr6:66880532 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -19.39 -0.61 3.14e-66 Exhaled nitric oxide output; BRCA cis rs11191270 1.000 rs4919626 chr10:104079818 T/C cg15320455 chr10:103880129 LDB1 0.49 8.0 0.3 5.96e-15 Intelligence (multi-trait analysis); BRCA trans rs9858542 0.953 rs35115732 chr3:49475155 T/C cg21659725 chr3:3221576 CRBN -0.45 -9.61 -0.36 1.65e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg12927641 chr6:109611667 NA -0.38 -9.38 -0.35 1.13e-19 Reticulocyte fraction of red cells; BRCA cis rs7766436 0.553 rs55936918 chr6:22610269 A/T cg13666174 chr6:22585274 NA -0.44 -7.99 -0.3 6.39e-15 Coronary artery disease; BRCA cis rs853679 0.517 rs2281588 chr6:28072602 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.15 -0.31 1.96e-15 Depression; BRCA cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg04317338 chr11:64019027 PLCB3 0.54 9.19 0.34 5.59e-19 Mean platelet volume; BRCA cis rs12477438 0.520 rs11123762 chr2:99727789 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.81 0.67 1.05e-84 Chronic sinus infection; BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg03354898 chr7:1950403 MAD1L1 -0.47 -9.48 -0.35 4.99e-20 Bipolar disorder and schizophrenia; BRCA trans rs853679 0.607 rs67662114 chr6:27932301 G/A cg06606381 chr12:133084897 FBRSL1 -0.89 -8.78 -0.33 1.44e-17 Depression; BRCA cis rs2742234 0.910 rs2505511 chr10:43641029 T/A cg02780029 chr10:43622663 RET -0.38 -9.34 -0.35 1.51e-19 Hirschsprung disease; BRCA cis rs9486719 1.000 rs2142652 chr6:96868504 A/C cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA cis rs611744 0.560 rs58605513 chr8:109279122 A/C cg21045802 chr8:109455806 TTC35 0.35 8.06 0.3 3.69e-15 Dupuytren's disease; BRCA cis rs1371614 0.589 rs3739086 chr2:27165202 T/C cg00617064 chr2:27272375 NA 0.32 8.57 0.32 7.69e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.27 -0.31 8e-16 Bipolar disorder; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg03709012 chr19:19516395 GATAD2A 0.81 18.99 0.6 4.17e-64 Tonsillectomy; BRCA cis rs965469 0.779 rs2236103 chr20:3276821 A/G cg25506879 chr20:3388711 C20orf194 0.44 8.9 0.33 5.93e-18 IFN-related cytopenia; BRCA cis rs2228479 0.681 rs10153055 chr16:89965842 C/T cg04013166 chr16:89971882 TCF25 0.44 8.59 0.32 6.46e-17 Skin colour saturation; BRCA trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg15934090 chr1:100435551 SLC35A3 0.35 7.93 0.3 1.01e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs6879260 1.000 rs6879260 chr5:179731014 A/G cg02891314 chr5:179741120 GFPT2 -0.67 -13.55 -0.47 6.29e-37 Height; BRCA cis rs35123781 1.000 rs601728 chr5:139057076 T/C cg05227215 chr5:139057496 CXXC5 0.35 8.47 0.32 1.64e-16 Schizophrenia; BRCA cis rs8062405 0.679 rs72793818 chr16:28893137 G/A cg09754948 chr16:28834200 ATXN2L 0.47 9.09 0.34 1.23e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs503734 0.502 rs2660803 chr3:100914035 A/G cg27318481 chr3:100970896 IMPG2 -0.37 -8.51 -0.32 1.28e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg22535103 chr8:58192502 C8orf71 -0.61 -13.17 -0.46 3.08e-35 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.731 rs6681857 chr1:46850124 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.37 -0.35 1.24e-19 Menopause (age at onset); BRCA cis rs910316 0.737 rs175065 chr14:75494983 T/C cg08847533 chr14:75593920 NEK9 -0.8 -19.53 -0.61 5.85e-67 Height; BRCA cis rs3806843 0.741 rs2563293 chr5:140110536 T/C cg16179182 chr5:140090404 VTRNA1-1 0.45 10.45 0.38 1.06e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs1865760 0.865 rs9393677 chr6:25945815 G/A cg16482183 chr6:26056742 HIST1H1C 0.5 10.23 0.38 7.56e-23 Height; BRCA cis rs2197308 0.765 rs2387436 chr12:37935337 C/T cg13010199 chr12:38710504 ALG10B -0.41 -8.87 -0.33 7.47e-18 Morning vs. evening chronotype; BRCA cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg22349387 chr12:9600060 DDX12 -0.42 -9.54 -0.35 2.94e-20 Breast size; BRCA cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg25237894 chr2:233734115 C2orf82 -0.36 -10.15 -0.37 1.48e-22 Coronary artery disease; BRCA trans rs66887589 0.870 rs10518336 chr4:120522934 G/A cg25214090 chr10:38739885 LOC399744 0.35 8.12 0.31 2.32e-15 Diastolic blood pressure; BRCA cis rs6542838 0.554 rs4311103 chr2:99538362 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -9.37 -0.35 1.2e-19 Fear of minor pain; BRCA cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg06618935 chr21:46677482 NA -0.37 -8.08 -0.3 3.29e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 3.04e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.721 rs12091503 chr1:46107868 T/C cg06784218 chr1:46089804 CCDC17 0.52 12.53 0.44 2.36e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7520050 0.966 rs61783200 chr1:46297403 T/C cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.38e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4742903 1.000 rs7350148 chr9:106883085 T/G cg14250997 chr9:106856677 SMC2 0.35 10.88 0.4 2.12e-25 High-grade serous ovarian cancer;Breast cancer; BRCA trans rs4650994 0.935 rs12039531 chr1:178515612 G/A cg05059571 chr16:84539110 KIAA1609 -0.43 -9.77 -0.36 4.27e-21 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7264396 0.570 rs1970576 chr20:34336720 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.82 0.3 2.17e-14 Total cholesterol levels; BRCA cis rs1707322 1.000 rs12077974 chr1:46384141 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.58 0.39 3.39e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs4596713 0.568 rs7850547 chr9:71747208 G/A cg16512924 chr15:28394682 HERC2 0.39 9.42 0.35 8.29e-20 Headache; BRCA trans rs71537559 1 rs71537559 chr6:27309779 G/C cg01620082 chr3:125678407 NA -0.74 -8.96 -0.33 3.45e-18 Squamous cell lung carcinoma; BRCA cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg00024416 chr22:24240387 NA -0.48 -11.22 -0.41 8.87e-27 Urinary 1,3-butadiene metabolite levels in smokers; BRCA trans rs1994135 0.669 rs10844629 chr12:33697096 T/A cg26384229 chr12:38710491 ALG10B 0.4 8.58 0.32 7.38e-17 Resting heart rate; BRCA cis rs6964587 1.000 rs416 chr7:91580571 A/G cg17063962 chr7:91808500 NA -0.53 -12.53 -0.44 2.43e-32 Breast cancer; BRCA cis rs589448 0.902 rs528974 chr12:69765918 A/T cg20891283 chr12:69753455 YEATS4 0.84 28.6 0.75 1.77e-116 Cerebrospinal fluid biomarker levels; BRCA cis rs12950390 0.814 rs4794099 chr17:45838358 T/C cg24803719 chr17:45855879 NA -0.32 -8.4 -0.32 2.95e-16 IgG glycosylation; BRCA cis rs7592578 0.679 rs59929070 chr2:191327852 A/G cg11845111 chr2:191398756 TMEM194B -0.71 -13.93 -0.48 1.05e-38 Diastolic blood pressure; BRCA cis rs7551345 0.653 rs7513301 chr1:31698473 C/T cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA cis rs36051895 0.632 rs62541958 chr9:5175621 T/C cg02405213 chr9:5042618 JAK2 -0.48 -8.72 -0.33 2.39e-17 Pediatric autoimmune diseases; BRCA cis rs7301826 0.651 rs2037789 chr12:131288292 C/T cg11011512 chr12:131303247 STX2 -0.51 -13.5 -0.47 1.05e-36 Plasma plasminogen activator levels; BRCA cis rs4363385 0.818 rs529077 chr1:153012149 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs2243480 0.831 rs7806717 chr7:65393174 A/G cg18252515 chr7:66147081 NA 0.84 12.14 0.43 1.2e-30 Diabetic kidney disease; BRCA cis rs4423214 0.840 rs1792235 chr11:71181473 C/T cg05163923 chr11:71159392 DHCR7 -0.57 -11.58 -0.42 2.84e-28 Vitamin D levels; BRCA cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg23422044 chr7:1970798 MAD1L1 -0.59 -10.55 -0.39 4.32e-24 Bipolar disorder; BRCA trans rs61931739 0.612 rs1906136 chr12:33905293 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.26 0.34 3.06e-19 Morning vs. evening chronotype; BRCA cis rs10752881 0.967 rs8179284 chr1:182974707 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg23711669 chr6:146136114 FBXO30 0.73 17.14 0.56 1.74e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg24812749 chr6:127587940 RNF146 0.68 15.55 0.52 1.82e-46 Breast cancer; BRCA cis rs9790314 0.687 rs1037888 chr3:160775251 A/T cg03342759 chr3:160939853 NMD3 -0.51 -9.81 -0.36 2.95e-21 Morning vs. evening chronotype; BRCA cis rs752010 0.695 rs11210509 chr1:42109311 A/G cg06885757 chr1:42089581 HIVEP3 0.23 8.41 0.32 2.71e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9394159 0.583 rs4713650 chr6:33616828 C/T cg14003231 chr6:33640908 ITPR3 -0.4 -10.04 -0.37 4.14e-22 Graves' disease; BRCA cis rs4595586 0.566 rs7307174 chr12:39368862 A/G cg26384229 chr12:38710491 ALG10B 0.37 8.18 0.31 1.58e-15 Morning vs. evening chronotype; BRCA cis rs67981189 0.766 rs2526852 chr14:71416167 T/C cg15816911 chr14:71606274 NA -0.36 -8.02 -0.3 5.17e-15 Schizophrenia; BRCA cis rs1215050 0.776 rs1627946 chr4:98844416 G/A cg05340658 chr4:99064831 C4orf37 -0.43 -9.79 -0.36 3.64e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2153535 0.580 rs7742689 chr6:8452433 C/A cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.71 12.4 0.44 8.82e-32 Renal function-related traits (BUN); BRCA cis rs3762637 1.000 rs16845530 chr3:122142447 T/C cg24169773 chr3:122142474 KPNA1 -0.43 -8.26 -0.31 8.17e-16 LDL cholesterol levels; BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 21.77 0.65 5.22e-79 Platelet count; BRCA trans rs6951245 1.000 rs78523927 chr7:1089458 T/C cg13565492 chr6:43139072 SRF -0.79 -10.92 -0.4 1.41e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs60843830 0.661 rs11674325 chr2:105517 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.64 0.32 4.61e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.88 -0.33 6.98e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 1.000 rs4454479 chr1:46423555 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.93 0.4 1.34e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 16.37 0.54 1.4e-50 Platelet count; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.81 -13.18 -0.46 3.06e-35 Platelet count; BRCA cis rs17270561 0.609 rs4712968 chr6:25760344 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg05623727 chr3:50126028 RBM5 -0.42 -9.88 -0.36 1.61e-21 Intelligence (multi-trait analysis); BRCA cis rs796364 0.951 rs971232 chr2:200792881 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.65 0.42 1.48e-28 Schizophrenia; BRCA cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg11608241 chr8:8085544 FLJ10661 0.28 7.86 0.3 1.63e-14 Mood instability; BRCA cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.95 -0.37 8.91e-22 Alzheimer's disease (late onset); BRCA cis rs1008375 0.933 rs6847966 chr4:17634255 G/A cg16339924 chr4:17578868 LAP3 0.63 15.92 0.53 2.55e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9815354 1.000 rs1994157 chr3:41897482 G/A cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg20701182 chr2:24300061 SF3B14 0.67 9.76 0.36 4.51e-21 Lymphocyte counts; BRCA cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg26384229 chr12:38710491 ALG10B 0.69 16.22 0.54 8.24e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs6545883 0.929 rs778155 chr2:61647901 A/G cg15711740 chr2:61764176 XPO1 0.53 12.83 0.45 1.13e-33 Tuberculosis; BRCA cis rs7777484 0.534 rs2533890 chr7:2828743 C/T cg19717773 chr7:2847554 GNA12 -0.48 -11.37 -0.41 2.06e-27 Height; BRCA trans rs4714291 0.698 rs9296321 chr6:40118352 C/T cg02267698 chr19:7991119 CTXN1 -0.45 -9.28 -0.34 2.66e-19 Strep throat; BRCA cis rs7408868 0.908 rs10416865 chr19:15277601 T/C cg14696996 chr19:15285081 NOTCH3 1.01 14.77 0.5 1.08e-42 Pulse pressure; BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg04267008 chr7:1944627 MAD1L1 -0.66 -13.99 -0.48 5.67e-39 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.754 rs34425882 chr4:120253177 G/A cg09307838 chr4:120376055 NA 0.64 14.05 0.49 2.77e-39 Corneal astigmatism; BRCA cis rs4680 1.000 rs165656 chr22:19948863 C/G cg23601416 chr22:19950040 COMT -0.28 -9.59 -0.35 1.99e-20 Blood metabolite levels; BRCA cis rs6580649 0.941 rs7957764 chr12:48429701 C/T cg24011408 chr12:48396354 COL2A1 -0.49 -8.02 -0.3 5.13e-15 Lung cancer; BRCA cis rs7294478 1.000 rs7294478 chr12:7266805 A/G cg01074767 chr12:7262137 C1RL;LOC283314 -0.28 -7.96 -0.3 7.85e-15 Neuritic plaque; BRCA cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.41 -0.32 2.6e-16 Colorectal cancer; BRCA cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg00677455 chr12:58241039 CTDSP2 0.79 17.66 0.57 4.05e-57 Multiple sclerosis; BRCA cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg05535760 chr7:792225 HEATR2 0.87 14.93 0.51 1.94e-43 Cerebrospinal P-tau181p levels; BRCA cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 8.61 0.32 5.8e-17 Mean platelet volume; BRCA cis rs600806 0.751 rs7551176 chr1:109961965 C/T cg20591472 chr1:110008990 SYPL2 0.32 7.89 0.3 1.35e-14 Intelligence (multi-trait analysis); BRCA cis rs3740540 0.507 rs897293 chr10:126290050 T/G cg04949429 chr10:126290192 LHPP 0.43 12.19 0.43 7.03e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA trans rs1974653 0.781 rs175164 chr22:20115562 C/T cg20152630 chr19:46405944 MYPOP 0.35 8.08 0.3 3.31e-15 Schizophrenia; BRCA cis rs7247513 0.964 rs12979795 chr19:12717847 C/T cg01871581 chr19:12707946 ZNF490 0.68 16.21 0.54 9.87e-50 Bipolar disorder; BRCA cis rs6700896 0.931 rs1938490 chr1:66132800 T/A cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs61931739 0.534 rs10844725 chr12:34009504 C/A cg13010199 chr12:38710504 ALG10B 0.47 8.99 0.34 2.84e-18 Morning vs. evening chronotype; BRCA trans rs9858542 0.903 rs11917431 chr3:49644012 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.22 -0.34 4.2e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg18016565 chr1:150552671 MCL1 -0.37 -8.58 -0.32 7.01e-17 Tonsillectomy; BRCA cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg12311346 chr5:56204834 C5orf35 -0.82 -16.93 -0.56 2.26e-53 Initial pursuit acceleration; BRCA cis rs6582630 0.537 rs66855609 chr12:38299029 T/C cg26384229 chr12:38710491 ALG10B 0.65 15.45 0.52 5.28e-46 Drug-induced liver injury (flucloxacillin); BRCA cis rs7267979 0.966 rs2227890 chr20:25260931 A/G cg08601574 chr20:25228251 PYGB 0.37 8.82 0.33 1.07e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3820928 1.000 rs1346618 chr2:227771988 C/T cg11843606 chr2:227700838 RHBDD1 0.39 8.53 0.32 1.04e-16 Pulmonary function; BRCA cis rs4363385 0.693 rs6668311 chr1:152964586 A/G cg21543102 chr1:152974771 SPRR3 -0.31 -8.85 -0.33 8.26e-18 Inflammatory skin disease; BRCA cis rs2882667 0.858 rs11959803 chr5:138451315 G/A cg04439458 chr5:138467593 SIL1 -0.43 -10.76 -0.39 6.08e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10870270 1.000 rs10781564 chr10:133757922 A/G cg08754478 chr10:133766260 PPP2R2D -0.68 -14.12 -0.49 1.33e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg11812906 chr14:75593930 NEK9 -0.67 -14.95 -0.51 1.48e-43 Height; BRCA cis rs9486719 0.947 rs12210834 chr6:96890407 A/T cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs3806843 0.766 rs2530239 chr5:140062547 C/T cg26395211 chr5:140044315 WDR55 0.38 8.57 0.32 7.73e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs2797160 1.000 rs2797160 chr6:126010116 A/G cg05901451 chr6:126070800 HEY2 0.4 9.72 0.36 6.35e-21 Endometrial cancer; BRCA cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.02 -0.4 5.67e-26 Lymphocyte counts; BRCA cis rs12681288 0.676 rs7459467 chr8:999359 C/T cg04851639 chr8:1020857 NA -0.4 -11.44 -0.41 1.09e-27 Schizophrenia; BRCA cis rs13053817 1.000 rs2106107 chr22:29835987 A/G cg20285224 chr22:29838184 RFPL1S;RFPL1 0.5 9.76 0.36 4.73e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs7677751 0.806 rs7673027 chr4:55096180 T/A cg17187183 chr4:55093834 PDGFRA 0.44 9.14 0.34 8.19e-19 Corneal astigmatism; BRCA cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg04166393 chr7:2884313 GNA12 0.49 9.24 0.34 3.74e-19 Height; BRCA cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg21918786 chr6:109611834 NA -0.44 -11.83 -0.42 2.49e-29 Reticulocyte fraction of red cells; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg08888203 chr3:10149979 C3orf24 0.68 14.49 0.5 2.36e-41 Alzheimer's disease; BRCA cis rs11051970 0.679 rs2733696 chr12:32554635 A/G cg24626660 chr12:32551988 NA 0.32 9.4 0.35 9.19e-20 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg11952622 chr19:58962976 ZNF324B 0.43 8.75 0.33 1.92e-17 Uric acid clearance; BRCA cis rs17685 0.735 rs11763339 chr7:75761541 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg11764359 chr7:65958608 NA -0.8 -19.34 -0.61 5.76e-66 Aortic root size; BRCA cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg01475377 chr6:109611718 NA -0.58 -16.27 -0.54 4.86e-50 Reticulocyte fraction of red cells; BRCA cis rs7246657 0.882 rs59224125 chr19:37963205 T/C cg14683738 chr19:37701593 ZNF585B 0.44 7.9 0.3 1.23e-14 Coronary artery calcification; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.09 -0.34 1.27e-18 Total body bone mineral density; BRCA cis rs1865760 0.516 rs9379819 chr6:26049819 A/C cg17691542 chr6:26056736 HIST1H1C 0.53 11.44 0.41 1.05e-27 Height; BRCA cis rs11971779 0.648 rs9656512 chr7:139054046 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.23 0.38 7.66e-23 Diisocyanate-induced asthma; BRCA cis rs724568 0.527 rs1430768 chr2:67929165 A/G cg14046302 chr2:67939758 NA -0.38 -10.22 -0.37 8.27e-23 Major depressive disorder (broad); BRCA cis rs2842992 0.872 rs1570318 chr6:160111473 C/T cg11366901 chr6:160182831 ACAT2 0.78 15.03 0.51 5.93e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs9948 0.655 rs17119562 chr2:97381844 G/C cg20312557 chr2:97357134 FER1L5 -0.59 -7.97 -0.3 7.54e-15 Erectile dysfunction and prostate cancer treatment; BRCA cis rs67460515 0.926 rs13062740 chr3:161024208 G/A cg17135325 chr3:160939158 NMD3 0.42 8.05 0.3 4.02e-15 Parkinson's disease; BRCA cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.83 -0.42 2.37e-29 Bipolar disorder; BRCA cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.6e-29 Bipolar disorder; BRCA cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.06 0.34 1.6e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs61931739 0.500 rs11052990 chr12:34058647 T/A cg26384229 chr12:38710491 ALG10B 0.68 14.37 0.49 9.31e-41 Morning vs. evening chronotype; BRCA cis rs2742540 0.503 rs11042121 chr11:8932640 A/C cg00186954 chr11:8933980 ST5;C11orf17 0.33 7.96 0.3 8.13e-15 Hematocrit; BRCA cis rs651907 1.000 rs651907 chr3:101600724 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.34 8.87 0.33 7.42e-18 Colorectal cancer; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg08888203 chr3:10149979 C3orf24 -0.68 -14.27 -0.49 2.67e-40 Alzheimer's disease; BRCA cis rs4595586 0.545 rs7970307 chr12:39380760 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg22920501 chr2:26401640 FAM59B -0.67 -11.5 -0.41 5.96e-28 Gut microbiome composition (summer); BRCA cis rs4237845 0.537 rs10747787 chr12:58260657 A/G cg00677455 chr12:58241039 CTDSP2 0.63 15.89 0.53 3.52e-48 Intelligence (multi-trait analysis); BRCA cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg03354898 chr7:1950403 MAD1L1 -0.47 -9.34 -0.35 1.54e-19 Schizophrenia; BRCA cis rs4948102 0.961 rs7776550 chr7:56092391 T/C cg09872392 chr7:56161020 PHKG1 -0.42 -9.71 -0.36 6.84e-21 Plasma homocysteine levels (post-methionine load test); BRCA cis rs8114671 0.647 rs1124511 chr20:33736697 A/C cg24642439 chr20:33292090 TP53INP2 0.41 8.86 0.33 7.58e-18 Height; BRCA cis rs875971 0.862 rs7803416 chr7:65954199 A/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs7640424 0.649 rs13093976 chr3:107864963 A/C cg09227934 chr3:107805635 CD47 0.37 7.94 0.3 9.07e-15 Body mass index; BRCA trans rs3780486 0.846 rs10813950 chr9:33127640 A/G cg04842962 chr6:43655489 MRPS18A -1.1 -35.79 -0.82 8.43e-155 IgG glycosylation; BRCA trans rs1493916 0.905 rs34910379 chr18:31400047 A/G cg27147174 chr7:100797783 AP1S1 -0.57 -11.47 -0.41 7.74e-28 Life satisfaction; BRCA cis rs853679 0.517 rs1904840 chr6:28108232 C/T cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.49e-15 Depression; BRCA cis rs1707322 0.964 rs796773 chr1:46564475 C/T cg03146154 chr1:46216737 IPP -0.43 -9.42 -0.35 8.22e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg25817165 chr18:72167213 CNDP2 -0.77 -19.52 -0.61 6.25e-67 Refractive error; BRCA cis rs9790314 0.502 rs7647118 chr3:161016165 T/C cg17135325 chr3:160939158 NMD3 0.4 7.93 0.3 9.61e-15 Morning vs. evening chronotype; BRCA cis rs757110 0.866 rs5215 chr11:17408630 C/T cg04705435 chr11:17411270 KCNJ11 0.48 10.33 0.38 3.13e-23 Type 2 diabetes; BRCA cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg01877450 chr7:97915802 BRI3 -0.36 -8.2 -0.31 1.34e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1580019 0.961 rs1868776 chr7:32494435 G/T cg06627557 chr7:32535165 LSM5;AVL9 -0.73 -15.92 -0.53 2.77e-48 Cognitive ability; BRCA cis rs867371 1.000 rs1501372 chr15:82468455 C/T cg00614314 chr15:82944287 LOC80154 0.43 9.04 0.34 1.81e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs16867321 0.588 rs2368175 chr2:181493763 G/C cg23363182 chr2:181467187 NA -0.49 -10.98 -0.4 8.5e-26 Obesity; BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg00814883 chr7:100076585 TSC22D4 -0.49 -9.61 -0.36 1.69e-20 Platelet count; BRCA cis rs6964587 1.000 rs7797369 chr7:91570615 C/A cg17063962 chr7:91808500 NA -0.53 -12.46 -0.44 4.56e-32 Breast cancer; BRCA cis rs28374715 0.662 rs28382348 chr15:41487934 G/C cg18705301 chr15:41695430 NDUFAF1 -0.87 -18.15 -0.58 1.07e-59 Ulcerative colitis; BRCA cis rs589448 0.902 rs315124 chr12:69771727 G/A cg14784868 chr12:69753453 YEATS4 0.77 25.08 0.7 3.64e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg00106254 chr7:1943704 MAD1L1 -0.41 -10.09 -0.37 2.52e-22 Bipolar disorder and schizophrenia; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -12.55 -0.44 1.94e-32 Bipolar disorder and schizophrenia; BRCA cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15541040 chr2:3486749 NA -0.42 -9.13 -0.34 9.26e-19 Neurofibrillary tangles; BRCA cis rs881375 0.967 rs7875829 chr9:123660398 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.95 0.4 1.12e-25 Rheumatoid arthritis; BRCA cis rs4845875 0.602 rs2001584 chr1:11841351 G/A cg24844545 chr1:11908347 NPPA 0.33 8.21 0.31 1.21e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg05639522 chr1:247681581 NA 0.47 10.47 0.38 8.46e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs3796352 0.881 rs34238610 chr3:53026480 A/T cg07884673 chr3:53033167 SFMBT1 0.86 9.98 0.37 6.83e-22 Immune reponse to smallpox (secreted IL-2); BRCA cis rs35123781 1.000 rs601324 chr5:139057179 C/G cg05227215 chr5:139057496 CXXC5 0.35 8.42 0.32 2.46e-16 Schizophrenia; BRCA cis rs6963495 0.818 rs73192107 chr7:105168095 G/A cg19920283 chr7:105172520 RINT1 0.59 9.46 0.35 5.64e-20 Bipolar disorder (body mass index interaction); BRCA cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg12463550 chr7:65579703 CRCP -0.38 -8.06 -0.3 3.67e-15 Aortic root size; BRCA cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg14019146 chr3:50243930 SLC38A3 -0.42 -10.28 -0.38 4.84e-23 Body mass index; BRCA cis rs27434 0.821 rs28337 chr5:96125314 A/T cg16492584 chr5:96139282 ERAP1 -0.46 -10.92 -0.4 1.46e-25 Ankylosing spondylitis; BRCA cis rs4302748 0.817 rs11773129 chr7:36186670 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs7927771 0.800 rs11039200 chr11:47379646 A/C cg20307385 chr11:47447363 PSMC3 -0.43 -8.44 -0.32 2.05e-16 Subjective well-being; BRCA trans rs7395662 0.929 rs11039903 chr11:48679705 G/T cg00717180 chr2:96193071 NA -0.29 -8.09 -0.3 3.04e-15 HDL cholesterol; BRCA cis rs6834538 0.597 rs6822451 chr4:113463265 G/A cg05166686 chr4:113558556 LARP7;C4orf21 0.43 10.39 0.38 1.82e-23 Free thyroxine concentration; BRCA cis rs290268 0.647 rs1333637 chr9:93557066 C/T cg02608019 chr9:93564028 SYK -0.49 -10.9 -0.4 1.74e-25 Platelet count; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg08470875 chr2:26401718 FAM59B 0.67 11.05 0.4 4.38e-26 Gut microbiome composition (summer); BRCA cis rs7554547 0.667 rs4846072 chr1:11950391 T/C cg13216073 chr1:12042593 MFN2 0.38 7.87 0.3 1.52e-14 Nonsyndromic cleft lip with cleft palate; BRCA cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.01 15.72 0.53 2.65e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1949733 0.816 rs2631746 chr4:8490934 C/T cg13073564 chr4:8508604 NA 0.39 10.94 0.4 1.17e-25 Response to antineoplastic agents; BRCA cis rs4803468 1.000 rs4803468 chr19:41922352 A/G cg09537434 chr19:41945824 ATP5SL -1.0 -23.92 -0.69 8.58e-91 Height; BRCA cis rs17270561 0.609 rs6941933 chr6:25745702 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.74 0.33 1.98e-17 Iron status biomarkers; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.45 -0.59 2.85e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs875971 0.545 rs1547529 chr7:65723846 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.06 0.37 3.32e-22 Aortic root size; BRCA cis rs2066819 1.000 rs76466034 chr12:56719450 G/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs4819052 0.959 rs9976074 chr21:46655638 G/T cg11663144 chr21:46675770 NA -0.46 -9.3 -0.35 2.14e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4728302 0.869 rs10156088 chr7:133592544 G/A cg07491979 chr7:133331646 EXOC4 0.36 7.89 0.3 1.31e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs6748734 0.779 rs6437371 chr2:241797424 G/C cg04034577 chr2:241836375 C2orf54 -0.5 -12.62 -0.45 9.24e-33 Urinary metabolites; BRCA cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.54 -8.52 -0.32 1.1e-16 Schizophrenia; BRCA cis rs12711979 0.765 rs881852 chr2:3821508 A/G cg17052675 chr2:3827356 NA -0.46 -13.47 -0.47 1.4e-36 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg17971929 chr21:40555470 PSMG1 -0.45 -9.41 -0.35 9.01e-20 Menarche (age at onset); BRCA cis rs6831352 0.918 rs17218162 chr4:100056060 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg19077165 chr18:44547161 KATNAL2 -0.5 -10.57 -0.39 3.39e-24 Personality dimensions; BRCA cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs11711311 1.000 rs1073040 chr3:113522123 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -10.78 -0.39 5.23e-25 IgG glycosylation; BRCA cis rs1577917 0.958 rs12216074 chr6:86520002 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.08 -0.43 2e-30 Response to antipsychotic treatment; BRCA cis rs9457247 0.765 rs9295385 chr6:167448181 A/G cg07741184 chr6:167504864 NA 0.29 8.07 0.3 3.58e-15 Crohn's disease; BRCA cis rs7631605 0.608 rs11715128 chr3:37440674 A/T cg15934958 chr3:37212084 LRRFIP2 0.37 7.89 0.3 1.28e-14 Cerebrospinal P-tau181p levels; BRCA cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg00852783 chr1:26633632 UBXN11 0.51 11.02 0.4 5.81e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs7727544 1.000 rs7727544 chr5:131590534 C/T cg11843238 chr5:131593191 PDLIM4 0.31 7.89 0.3 1.35e-14 Blood metabolite levels; BRCA cis rs826838 1.000 rs55828987 chr12:39056421 A/C cg26384229 chr12:38710491 ALG10B 0.83 22.36 0.66 2.87e-82 Heart rate; BRCA cis rs2764208 0.576 rs6457791 chr6:34759954 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.33e-15 Systemic lupus erythematosus; BRCA cis rs4689388 0.890 rs6838400 chr4:6295427 C/G cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs586533 0.881 rs599609 chr11:99505610 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs12497850 0.764 rs6784111 chr3:49178846 T/C cg06212747 chr3:49208901 KLHDC8B 0.52 10.76 0.39 6.11e-25 Parkinson's disease; BRCA cis rs10463316 0.894 rs7727770 chr5:150767116 G/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.17e-16 Metabolite levels (Pyroglutamine); BRCA trans rs35110281 0.807 rs2838328 chr21:45023234 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.51 0.32 1.22e-16 Mean corpuscular volume; BRCA cis rs2276314 0.947 rs16967319 chr18:33573525 A/G cg05985134 chr18:33552581 C18orf21 0.67 12.17 0.43 8.16e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1048238 0.506 rs7552077 chr1:16196759 A/G cg16109817 chr1:16162209 FLJ37453 -0.3 -8.25 -0.31 8.85e-16 Systolic blood pressure; BRCA cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.84 -0.45 9.92e-34 Bipolar disorder; BRCA cis rs6750047 0.719 rs4670232 chr2:38272033 C/G cg07380506 chr2:38303506 CYP1B1 0.43 9.61 0.36 1.61e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs3820928 0.874 rs10933163 chr2:227815286 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -9.06 -0.34 1.6e-18 Pulmonary function; BRCA cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg16230307 chr14:35515116 FAM177A1 0.73 15.06 0.51 4.55e-44 Psoriasis; BRCA cis rs4319547 0.910 rs6416298 chr12:123002143 C/T cg05707623 chr12:122985044 ZCCHC8 -0.54 -9.77 -0.36 4.2e-21 Body mass index; BRCA cis rs4728302 0.869 rs2042455 chr7:133580545 A/G cg07491979 chr7:133331646 EXOC4 0.36 7.81 0.3 2.28e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs6964587 0.773 rs17757926 chr7:91987702 T/C cg17063962 chr7:91808500 NA 0.53 11.77 0.42 4.53e-29 Breast cancer; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg07308232 chr7:1071921 C7orf50 -0.4 -8.18 -0.31 1.5e-15 Longevity;Endometriosis; BRCA trans rs1941687 0.764 rs1493915 chr18:31377582 G/T cg27147174 chr7:100797783 AP1S1 -0.38 -7.82 -0.3 2.26e-14 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs9359856 0.510 rs4235839 chr6:90472410 A/G cg13799429 chr6:90582589 CASP8AP2 0.72 11.06 0.4 3.84e-26 Bipolar disorder; BRCA cis rs7586879 0.520 rs6718511 chr2:25122324 A/G cg04586622 chr2:25135609 ADCY3 0.47 11.64 0.42 1.54e-28 Body mass index; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg22907277 chr7:1156413 C7orf50 0.51 11.46 0.41 9.19e-28 Longevity;Endometriosis; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg09177884 chr7:1199841 ZFAND2A 0.51 10.97 0.4 9e-26 Longevity;Endometriosis; BRCA cis rs897984 0.684 rs6950 chr16:30995669 T/C cg00531865 chr16:30841666 NA 0.39 9.38 0.35 1.17e-19 Dementia with Lewy bodies; BRCA cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg00012203 chr2:219082015 ARPC2 -0.49 -9.05 -0.34 1.67e-18 Colorectal cancer; BRCA cis rs7809950 1.000 rs2250414 chr7:107140987 T/G cg23024343 chr7:107201750 COG5 -0.39 -9.09 -0.34 1.25e-18 Coronary artery disease; BRCA cis rs919433 0.963 rs12617117 chr2:198155170 T/A cg00792783 chr2:198669748 PLCL1 -0.38 -8.0 -0.3 5.75e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1401999 0.932 rs4148557 chr3:183733784 A/G cg01324343 chr3:183735012 ABCC5 0.81 20.24 0.62 9.63e-71 Anterior chamber depth; BRCA cis rs6963495 0.818 rs73192122 chr7:105171471 G/A cg19920283 chr7:105172520 RINT1 0.59 9.22 0.34 4.15e-19 Bipolar disorder (body mass index interaction); BRCA cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg20908204 chr19:46285434 DMPK 0.27 8.19 0.31 1.38e-15 Coronary artery disease; BRCA cis rs1707322 0.717 rs28752166 chr1:46213309 G/A cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10463316 0.604 rs28744577 chr5:150768983 A/T cg03212797 chr5:150827313 SLC36A1 -0.42 -8.34 -0.31 4.68e-16 Metabolite levels (Pyroglutamine); BRCA cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.84 0.33 8.98e-18 Personality dimensions; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.75 16.65 0.55 5.51e-52 Lymphocyte counts; BRCA trans rs2727020 0.701 rs7949044 chr11:49597334 C/T cg15704280 chr7:45808275 SEPT13 -0.77 -17.33 -0.57 1.84e-55 Coronary artery disease; BRCA trans rs12310956 0.532 rs10844719 chr12:33987714 A/G cg26384229 chr12:38710491 ALG10B 0.51 10.96 0.4 1.02e-25 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs1605900 chr2:200870197 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.25 0.41 6.32e-27 Schizophrenia; BRCA cis rs634534 0.532 rs12794370 chr11:65770413 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.43 10.56 0.39 3.72e-24 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs9914988 0.943 rs9902953 chr17:27139834 C/A cg20469991 chr17:27169893 C17orf63 -0.43 -8.5 -0.32 1.31e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs9858542 0.953 rs10640 chr3:49454277 G/A cg21659725 chr3:3221576 CRBN -0.48 -10.19 -0.37 1.06e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7772486 0.738 rs2246334 chr6:146183635 G/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.61 -0.36 1.63e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg13010199 chr12:38710504 ALG10B 0.5 9.85 0.36 2.1e-21 Bladder cancer; BRCA cis rs9790314 1.000 rs189270 chr3:161063504 T/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.26 -0.49 3e-40 Morning vs. evening chronotype; BRCA cis rs780094 0.564 rs4665978 chr2:27648726 T/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -8.17 -0.31 1.68e-15 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs9467773 0.620 rs2504565 chr6:26656890 G/A cg11502198 chr6:26597334 ABT1 0.55 11.74 0.42 6.04e-29 Intelligence (multi-trait analysis); BRCA cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg26116260 chr4:7069785 GRPEL1 0.94 27.86 0.74 1.94e-112 Monocyte percentage of white cells; BRCA cis rs72772090 0.539 rs11747896 chr5:96113397 A/G cg17330273 chr5:96107758 CAST;ERAP1 0.57 12.3 0.44 2.33e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg11941060 chr3:133502564 NA -0.5 -11.82 -0.42 2.71e-29 Iron status biomarkers; BRCA trans rs12310956 0.510 rs4931758 chr12:33871870 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.94 0.37 9.33e-22 Morning vs. evening chronotype; BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg22920501 chr2:26401640 FAM59B 0.95 16.82 0.55 7.55e-53 Gut microbiome composition (summer); BRCA cis rs6840360 0.571 rs17275536 chr4:152498625 C/T cg22705602 chr4:152727874 NA -0.32 -8.17 -0.31 1.6e-15 Intelligence (multi-trait analysis); BRCA cis rs6598955 0.671 rs12086573 chr1:26574330 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs400736 0.930 rs370812 chr1:8075894 C/T cg25007680 chr1:8021821 PARK7 0.48 12.05 0.43 2.87e-30 Response to antidepressants and depression; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs3733585 0.624 rs7376154 chr4:9952587 C/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.32 -0.38 3.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.651 rs2420596 chr7:65915983 T/C cg18876405 chr7:65276391 NA 0.51 11.55 0.42 3.6e-28 Aortic root size; BRCA cis rs1707322 1.000 rs4073847 chr1:46463012 A/C cg06784218 chr1:46089804 CCDC17 -0.45 -10.62 -0.39 2.3e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg02297831 chr4:17616191 MED28 0.36 8.51 0.32 1.21e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9469890 0.604 rs11756280 chr6:34503439 T/C cg17674042 chr6:34482479 PACSIN1 -0.33 -8.56 -0.32 8.1e-17 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs453301 0.658 rs6986044 chr8:8874786 G/C cg15556689 chr8:8085844 FLJ10661 -0.33 -8.56 -0.32 8.12e-17 Joint mobility (Beighton score); BRCA cis rs73001065 0.818 rs58847337 chr19:19726022 G/A cg03709012 chr19:19516395 GATAD2A 0.75 9.37 0.35 1.18e-19 LDL cholesterol; BRCA trans rs6951245 1.000 rs79422648 chr7:1080241 T/C cg13565492 chr6:43139072 SRF -0.79 -11.12 -0.4 2.25e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg10523679 chr1:76189770 ACADM -0.5 -9.69 -0.36 8.41e-21 Daytime sleep phenotypes; BRCA cis rs763121 1.000 rs1946990 chr22:38912771 C/T cg06544989 chr22:39130855 UNC84B -0.37 -9.61 -0.36 1.58e-20 Menopause (age at onset); BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg13047869 chr3:10149882 C3orf24 -0.53 -11.45 -0.41 9.7e-28 Alzheimer's disease; BRCA cis rs13053817 0.898 rs7291001 chr22:29857859 C/G cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.48 -9.25 -0.34 3.35e-19 Carotid atherosclerosis in HIV infection; BRCA trans rs7615952 0.604 rs9837847 chr3:125623919 G/A cg07211511 chr3:129823064 LOC729375 -0.96 -13.67 -0.48 1.64e-37 Blood pressure (smoking interaction); BRCA cis rs4919087 0.962 rs10882891 chr10:99059645 C/A cg25902810 chr10:99078978 FRAT1 0.5 10.79 0.39 4.96e-25 Monocyte count; BRCA cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg18446336 chr7:2847575 GNA12 -0.35 -8.24 -0.31 9.82e-16 Height; BRCA cis rs12291225 0.679 rs4756786 chr11:14285900 C/A cg19336497 chr11:14380999 RRAS2 -0.48 -11.8 -0.42 3.33e-29 Sense of smell; BRCA cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg16482183 chr6:26056742 HIST1H1C 0.53 11.23 0.41 8.17e-27 Height; BRCA cis rs11190604 1.000 rs2273694 chr10:102256496 G/T cg07080220 chr10:102295463 HIF1AN 0.58 13.5 0.47 9.99e-37 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg03647239 chr10:116582469 FAM160B1 0.36 7.95 0.3 8.65e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg08742575 chr21:47604166 C21orf56 -0.4 -7.82 -0.3 2.26e-14 Testicular germ cell tumor; BRCA cis rs796364 0.806 rs11688168 chr2:200916004 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.9 -30.68 -0.77 9.51e-128 Chronic sinus infection; BRCA cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.09 -0.3 2.94e-15 Aortic root size; BRCA cis rs11105298 0.891 rs11105314 chr12:89924559 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.54 -0.35 2.94e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs4595586 0.545 rs7976609 chr12:39394317 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg27624424 chr6:160112604 SOD2 -0.4 -8.47 -0.32 1.64e-16 Age-related macular degeneration (geographic atrophy); BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg25036284 chr2:26402008 FAM59B -0.63 -10.62 -0.39 2.29e-24 Gut microbiome composition (summer); BRCA trans rs9929218 0.529 rs8059194 chr16:68749663 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.98 29.42 0.76 6.09e-121 Colorectal cancer; BRCA cis rs4805272 0.539 rs17591634 chr19:29331628 A/C cg12756686 chr19:29218302 NA -0.5 -8.81 -0.33 1.2e-17 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.38 8.37 0.31 3.68e-16 Multiple sclerosis; BRCA cis rs3824867 0.920 rs4282946 chr11:47456202 G/A cg20307385 chr11:47447363 PSMC3 0.51 11.55 0.42 3.81e-28 Mean corpuscular hemoglobin; BRCA cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg21475434 chr5:93447410 FAM172A 0.67 8.73 0.33 2.25e-17 Diabetic retinopathy; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -8.87 -0.33 7.57e-18 Menopause (age at onset); BRCA cis rs4363385 0.747 rs4845507 chr1:152968414 T/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.3 -0.31 6.13e-16 Inflammatory skin disease; BRCA cis rs11098499 0.691 rs12502524 chr4:120271414 G/A cg09307838 chr4:120376055 NA 0.6 13.01 0.46 1.7e-34 Corneal astigmatism; BRCA cis rs4363385 0.693 rs368076 chr1:153046514 A/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.04 -0.3 4.26e-15 Inflammatory skin disease; BRCA cis rs1050631 0.564 rs684890 chr18:33744677 T/C cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.92 -0.3 1.07e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs6582630 0.539 rs4882324 chr12:38499180 T/C cg26384229 chr12:38710491 ALG10B -0.44 -10.19 -0.37 1.06e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05901451 chr6:126070800 HEY2 -0.39 -9.48 -0.35 4.8e-20 Endometrial cancer; BRCA cis rs3733585 0.699 rs28837683 chr4:9959808 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.83 -0.39 3.35e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3806843 1.000 rs7732179 chr5:140199039 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.93 -0.37 1.06e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6912958 0.702 rs2300909 chr6:88212100 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -8.76 -0.33 1.75e-17 Monocyte percentage of white cells; BRCA cis rs2404602 0.735 rs4886495 chr15:76738959 C/T cg23625390 chr15:77176239 SCAPER 0.54 13.95 0.48 8.6e-39 Blood metabolite levels; BRCA cis rs965469 1.000 rs965469 chr20:3381549 T/C cg25506879 chr20:3388711 C20orf194 -0.54 -10.36 -0.38 2.44e-23 IFN-related cytopenia; BRCA cis rs7072216 0.763 rs6584205 chr10:100173806 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 8.8e-21 Metabolite levels; BRCA cis rs490234 0.702 rs10120000 chr9:128288428 C/T cg14078157 chr9:128172775 NA -0.49 -11.12 -0.4 2.17e-26 Mean arterial pressure; BRCA cis rs9467773 1.000 rs6903973 chr6:26499942 C/A cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.23e-60 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.906 rs59336968 chr8:58176857 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg20801007 chr11:830320 EFCAB4A -0.49 -10.62 -0.39 2.3e-24 Mean platelet volume; BRCA trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21659725 chr3:3221576 CRBN -0.5 -12.81 -0.45 1.31e-33 Intelligence (multi-trait analysis); BRCA cis rs6430585 0.591 rs75223002 chr2:136525309 G/T cg07169764 chr2:136633963 MCM6 1.23 26.49 0.72 6.67e-105 Corneal structure; BRCA cis rs17092148 1.000 rs910871 chr20:33333208 C/A cg16810054 chr20:33298113 TP53INP2 -0.5 -11.31 -0.41 3.74e-27 Neuroticism; BRCA cis rs912057 0.671 rs1294425 chr6:6744292 G/A cg06612196 chr6:6737390 NA 0.46 10.85 0.39 2.81e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs6977660 0.714 rs4721827 chr7:19825655 A/G cg07541023 chr7:19748670 TWISTNB 0.55 9.61 0.36 1.58e-20 Thyroid stimulating hormone; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg04267008 chr7:1944627 MAD1L1 -0.63 -14.28 -0.49 2.45e-40 Bipolar disorder and schizophrenia; BRCA cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg04455712 chr21:45112962 RRP1B 0.39 10.38 0.38 1.91e-23 Mean corpuscular volume; BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.61 0.39 2.51e-24 Tonsillectomy; BRCA cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs701145 0.585 rs357476 chr3:153892844 A/G cg17054900 chr3:154042577 DHX36 -0.55 -9.39 -0.35 1.01e-19 Coronary artery disease; BRCA cis rs2404602 1.000 rs12594212 chr15:76802014 T/A cg23625390 chr15:77176239 SCAPER 0.43 10.59 0.39 3.03e-24 Blood metabolite levels; BRCA cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg09455208 chr3:40491958 NA 0.41 9.77 0.36 4.28e-21 Renal cell carcinoma; BRCA cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA trans rs11088226 0.846 rs2833884 chr21:33923075 A/G cg09050820 chr6:167586206 TCP10L2 0.57 10.65 0.39 1.65e-24 Gastritis; BRCA cis rs6977660 0.714 rs10251774 chr7:19790489 T/C cg05791153 chr7:19748676 TWISTNB 0.66 11.55 0.42 3.79e-28 Thyroid stimulating hormone; BRCA trans rs6089829 0.851 rs6089827 chr20:61668845 C/T cg23505145 chr19:12996616 KLF1 0.55 12.4 0.44 8.22e-32 Prostate cancer (SNP x SNP interaction); BRCA trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg03929089 chr4:120376271 NA -0.9 -22.93 -0.67 2.36e-85 Coronary artery disease; BRCA trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg11887960 chr12:57824829 NA 0.55 8.55 0.32 8.82e-17 Lung disease severity in cystic fibrosis; BRCA cis rs10129255 0.500 rs988133 chr14:107184963 A/G cg07958169 chr14:107095056 NA -0.4 -8.62 -0.32 5.2e-17 Kawasaki disease; BRCA trans rs853679 0.607 rs34396849 chr6:28250955 A/C cg01620082 chr3:125678407 NA -0.83 -10.07 -0.37 2.97e-22 Depression; BRCA cis rs11229555 0.645 rs12295551 chr11:58188983 T/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg05457628 chr5:178986728 RUFY1 0.41 8.57 0.32 7.48e-17 Lung cancer; BRCA cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg02574844 chr11:5959923 NA -0.39 -7.85 -0.3 1.72e-14 DNA methylation (variation); BRCA cis rs7824557 0.591 rs2572452 chr8:11228254 C/T cg21775007 chr8:11205619 TDH -0.63 -14.16 -0.49 8.54e-40 Retinal vascular caliber; BRCA cis rs6089829 0.962 rs6062393 chr20:61663230 G/A cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7512552 0.839 rs7523428 chr1:150430472 G/A cg15654264 chr1:150340011 RPRD2 0.4 8.56 0.32 8.26e-17 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs78707713 0.841 rs12242391 chr10:71201504 C/T cg12610070 chr10:71211762 TSPAN15 -0.32 -8.32 -0.31 5.38e-16 Venous thromboembolism; BRCA cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg18512352 chr11:47633146 NA -0.34 -8.21 -0.31 1.2e-15 Subjective well-being; BRCA cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.37 8.35 0.31 4.1e-16 Coronary artery disease; BRCA cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13126279 chr21:47581558 C21orf56 -0.44 -9.81 -0.36 2.99e-21 Testicular germ cell tumor; BRCA cis rs757110 0.868 rs5219 chr11:17409572 T/C cg15432903 chr11:17409602 KCNJ11 0.81 17.65 0.57 4.13e-57 Type 2 diabetes; BRCA cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -9.09 -0.34 1.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.644 rs11088472 chr21:40699376 A/C cg11890956 chr21:40555474 PSMG1 -0.82 -19.71 -0.61 6.59e-68 Cognitive function; BRCA cis rs6724607 1.000 rs13410230 chr2:191446252 A/G cg21644426 chr2:191273491 MFSD6 0.44 11.23 0.41 7.76e-27 Pulse pressure; BRCA cis rs2075371 0.966 rs1646676 chr7:133999267 G/A cg02659138 chr7:134003124 SLC35B4 0.34 10.62 0.39 2.22e-24 Mean platelet volume; BRCA cis rs11676348 0.818 rs1126579 chr2:219000734 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.4 -8.42 -0.32 2.44e-16 Ulcerative colitis; BRCA cis rs672059 1.000 rs483783 chr1:183162152 G/T ch.1.3577855R chr1:183094577 LAMC1 0.38 8.81 0.33 1.13e-17 Hypertriglyceridemia; BRCA cis rs1707322 0.964 rs785508 chr1:46527159 G/A cg06784218 chr1:46089804 CCDC17 -0.45 -10.73 -0.39 7.88e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4906332 1.000 rs7155822 chr14:103922390 A/G cg04998671 chr14:104000505 TRMT61A -0.42 -9.03 -0.34 2.02e-18 Coronary artery disease; BRCA cis rs13191362 0.507 rs2023036 chr6:163122736 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.56 10.66 0.39 1.63e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3733585 0.631 rs3822236 chr4:10119961 T/G cg11266682 chr4:10021025 SLC2A9 -0.41 -10.24 -0.38 6.9e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7809950 0.678 rs7788330 chr7:106985648 G/T cg23024343 chr7:107201750 COG5 -0.48 -9.6 -0.36 1.7e-20 Coronary artery disease; BRCA trans rs208520 0.874 rs208512 chr6:66943869 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.82 -15.32 -0.52 2.46e-45 Exhaled nitric oxide output; BRCA cis rs7927771 0.524 rs7124396 chr11:47787434 T/G cg20307385 chr11:47447363 PSMC3 -0.4 -9.51 -0.35 3.69e-20 Subjective well-being; BRCA cis rs7246657 0.508 rs10419845 chr19:37491192 G/T cg23950597 chr19:37808831 NA -0.58 -8.34 -0.31 4.44e-16 Coronary artery calcification; BRCA cis rs7786808 0.707 rs62479983 chr7:158227613 G/A cg01191920 chr7:158217561 PTPRN2 -0.46 -11.09 -0.4 2.83e-26 Obesity-related traits; BRCA cis rs7582180 0.591 rs12991577 chr2:101010867 C/A cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.15e-14 Intelligence (multi-trait analysis); BRCA cis rs877282 0.898 rs12359731 chr10:759497 A/G cg17470449 chr10:769945 NA 0.46 8.11 0.31 2.69e-15 Uric acid levels; BRCA cis rs1865760 0.566 rs7772312 chr6:26049616 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.62 0.42 1.82e-28 Height; BRCA cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.46 0.5 3.41e-41 Personality dimensions; BRCA cis rs701145 0.585 rs2060622 chr3:153833862 A/T cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.89e-18 Coronary artery disease; BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs7246967 0.611 rs66866654 chr19:22813739 A/G cg23217946 chr19:22817039 ZNF492 0.47 8.43 0.32 2.22e-16 Bronchopulmonary dysplasia; BRCA cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.56 -0.44 1.79e-32 Bipolar disorder; BRCA cis rs2066819 1.000 rs2306693 chr12:56680531 T/C cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs7646881 0.812 rs73015644 chr3:158447744 C/T cg19483011 chr3:158453295 NA -0.5 -8.58 -0.32 7.34e-17 Tetralogy of Fallot; BRCA cis rs10751667 0.643 rs10751671 chr11:944479 T/G ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs6545883 0.929 rs6545877 chr2:61741947 T/C cg15711740 chr2:61764176 XPO1 -0.55 -14.21 -0.49 5.23e-40 Tuberculosis; BRCA trans rs9325144 0.560 rs10785573 chr12:38654166 G/A cg23762105 chr12:34175262 ALG10 0.34 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs68112919 chr8:58188247 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.43e-37 Developmental language disorder (linguistic errors); BRCA cis rs2070488 0.775 rs961179 chr3:38509618 G/A cg24069376 chr3:38537580 EXOG 0.34 9.34 0.35 1.56e-19 Electrocardiographic conduction measures; BRCA cis rs17601876 0.545 rs61018102 chr15:51533530 G/C cg19946085 chr15:51559439 CYP19A1 -0.3 -8.17 -0.31 1.64e-15 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg00409905 chr10:38381863 ZNF37A 0.49 10.62 0.39 2.31e-24 Extrinsic epigenetic age acceleration; BRCA cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg06115741 chr20:33292138 TP53INP2 -0.37 -8.27 -0.31 8.04e-16 Glomerular filtration rate (creatinine); BRCA cis rs10782582 0.609 rs11161848 chr1:76367722 A/G cg03433033 chr1:76189801 ACADM -0.39 -7.85 -0.3 1.74e-14 Daytime sleep phenotypes; BRCA cis rs870825 0.929 rs72689261 chr4:185590897 C/A cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs12986413 0.846 rs12609327 chr19:2183000 A/C cg09261902 chr19:2140048 AP3D1 0.37 9.41 0.35 8.88e-20 Height; BRCA cis rs12310956 0.532 rs1589903 chr12:33943019 C/T cg06521331 chr12:34319734 NA -0.61 -11.16 -0.4 1.47e-26 Morning vs. evening chronotype; BRCA cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.5 -9.34 -0.35 1.5700000000000001e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.42 -0.41 1.24e-27 Gut microbiome composition (summer); BRCA cis rs3733585 0.773 rs13107466 chr4:10019390 G/A cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.97e-35 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7615952 0.599 rs1875683 chr3:125732481 C/G cg07211511 chr3:129823064 LOC729375 -0.62 -10.94 -0.4 1.23e-25 Blood pressure (smoking interaction); BRCA cis rs10492096 0.947 rs11064227 chr12:6598043 A/G cg13857086 chr12:6580257 VAMP1 0.42 8.33 0.31 4.86e-16 Hip geometry; BRCA trans rs208520 0.690 rs207118 chr6:66788948 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg22903471 chr2:27725779 GCKR -0.36 -8.88 -0.33 6.67e-18 Total body bone mineral density; BRCA cis rs2243480 1.000 rs709607 chr7:65449541 C/G cg18252515 chr7:66147081 NA 0.76 10.89 0.4 1.97e-25 Diabetic kidney disease; BRCA cis rs72627509 0.904 rs12645070 chr4:57770106 G/A cg26694713 chr4:57773883 REST 0.46 8.6 0.32 6.25e-17 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs4820539 0.966 rs5759594 chr22:23470660 G/A cg14186256 chr22:23484241 RTDR1 0.78 24.58 0.7 2.12e-94 Bone mineral density; BRCA cis rs2599510 0.783 rs2038534 chr2:32659489 G/A cg02381751 chr2:32503542 YIPF4 0.43 8.41 0.32 2.75e-16 Interleukin-18 levels; BRCA trans rs61931739 0.890 rs1705753 chr12:34144594 C/T cg26384229 chr12:38710491 ALG10B 0.43 10.55 0.39 4.07e-24 Morning vs. evening chronotype; BRCA trans rs1997103 0.954 rs9649780 chr7:55411741 A/C cg20935933 chr6:143382018 AIG1 0.61 11.7 0.42 8.67e-29 QRS interval (sulfonylurea treatment interaction); BRCA cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg01579765 chr21:45077557 HSF2BP -0.39 -10.31 -0.38 3.61e-23 Mean corpuscular volume; BRCA cis rs10501293 0.956 rs10768918 chr11:43134481 C/T cg03447554 chr11:43094025 NA -0.47 -8.65 -0.32 4.08e-17 Cognitive performance; BRCA cis rs13082711 0.522 rs653886 chr3:27343549 C/T cg02860705 chr3:27208620 NA 0.42 8.84 0.33 9.21e-18 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs4595586 0.679 rs7955725 chr12:39322903 C/T cg26384229 chr12:38710491 ALG10B 0.39 8.88 0.33 6.66e-18 Morning vs. evening chronotype; BRCA cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 16.17 0.54 1.54e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg11644478 chr21:40555479 PSMG1 -0.52 -10.88 -0.4 2.07e-25 Menarche (age at onset); BRCA cis rs7772486 0.875 rs11155452 chr6:146424631 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.76 -0.33 1.77e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs208520 0.874 rs208517 chr6:66947040 G/T cg07460842 chr6:66804631 NA -0.89 -15.83 -0.53 7.13e-48 Exhaled nitric oxide output; BRCA cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg27015174 chr15:43622946 ADAL;LCMT2 0.52 9.92 0.37 1.1e-21 Lung cancer in ever smokers; BRCA cis rs6061231 0.793 rs6061512 chr20:60976929 G/A cg22633769 chr20:60982531 CABLES2 0.43 7.95 0.3 8.7e-15 Colorectal cancer; BRCA cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg03146154 chr1:46216737 IPP -0.5 -11.16 -0.4 1.55e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg11833968 chr6:79620685 NA -0.42 -9.52 -0.35 3.55e-20 Intelligence (multi-trait analysis); BRCA trans rs17685 0.784 rs1613890 chr7:75735037 T/C cg19862616 chr7:65841803 NCRNA00174 0.84 27.31 0.73 1.94e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs8017423 0.630 rs12589687 chr14:90819570 C/G cg04374321 chr14:90722782 PSMC1 -0.5 -11.93 -0.43 8.85e-30 Mortality in heart failure; BRCA cis rs7766436 0.648 rs6908475 chr6:22572798 A/G cg13666174 chr6:22585274 NA -0.39 -9.83 -0.36 2.39e-21 Coronary artery disease; BRCA cis rs8072100 0.790 rs11079783 chr17:45686016 C/T cg25173405 chr17:45401733 C17orf57 0.55 11.83 0.42 2.47e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs739401 0.611 rs450817 chr11:3056712 A/G cg25174290 chr11:3078921 CARS 0.44 13.73 0.48 8.43e-38 Longevity; BRCA cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg11266682 chr4:10021025 SLC2A9 0.49 13.08 0.46 8.02e-35 Bone mineral density; BRCA cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.48 8.54 0.32 9.65e-17 Schizophrenia; BRCA trans rs7615952 0.599 rs66532274 chr3:125731845 G/A cg07211511 chr3:129823064 LOC729375 -0.58 -11.02 -0.4 5.39e-26 Blood pressure (smoking interaction); BRCA cis rs2882667 0.690 rs6596455 chr5:138167105 T/C cg04439458 chr5:138467593 SIL1 0.34 8.47 0.32 1.73e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg00958927 chr1:175162553 KIAA0040 -0.21 -7.85 -0.3 1.71e-14 Alcohol dependence; BRCA cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.81 -0.55 9.16e-53 Axial length; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 7.82 0.3 2.18e-14 Platelet count; BRCA cis rs10752881 1.000 rs6673559 chr1:182983197 G/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.41e-52 Colorectal cancer; BRCA trans rs2204008 0.807 rs11182461 chr12:38539288 T/C cg06521331 chr12:34319734 NA -0.51 -9.36 -0.35 1.32e-19 Bladder cancer; BRCA cis rs9790314 0.715 rs9290065 chr3:160776964 A/G cg04691961 chr3:161091175 C3orf57 0.41 8.69 0.33 3.09e-17 Morning vs. evening chronotype; BRCA cis rs6088580 0.634 rs6120669 chr20:33105028 T/C cg06115741 chr20:33292138 TP53INP2 0.39 8.73 0.33 2.22e-17 Glomerular filtration rate (creatinine); BRCA trans rs208520 0.526 rs7771233 chr6:66819784 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.08 -34.85 -0.81 6.59e-150 Exhaled nitric oxide output; BRCA cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg11822812 chr5:140052017 DND1 -0.3 -8.32 -0.31 5.16e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs4363385 0.818 rs574649 chr1:153008471 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg00631329 chr6:26305371 NA -0.43 -12.88 -0.45 6.66e-34 Educational attainment; BRCA cis rs7267979 0.868 rs6138550 chr20:25223430 C/T cg08601574 chr20:25228251 PYGB 0.39 9.5 0.35 4.08e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg04267008 chr7:1944627 MAD1L1 -0.57 -11.87 -0.43 1.65e-29 Bipolar disorder and schizophrenia; BRCA cis rs250677 0.687 rs250679 chr5:148434952 A/T cg12140854 chr5:148520817 ABLIM3 0.42 8.85 0.33 8.75e-18 Breast cancer; BRCA cis rs4975616 0.773 rs414965 chr5:1324121 G/A cg26373071 chr5:1325741 CLPTM1L 0.45 10.62 0.39 2.25e-24 Lung cancer; BRCA cis rs12477438 0.765 rs10193039 chr2:99692373 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.67 -15.97 -0.53 1.41e-48 Chronic sinus infection; BRCA cis rs2839186 0.872 rs13052495 chr21:47707474 G/A cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15320075 chr8:145703422 NA -0.42 -9.12 -0.34 9.49e-19 Age at first birth; BRCA cis rs10751667 0.621 rs10794348 chr11:939941 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.19e-47 Alzheimer's disease (late onset); BRCA cis rs7524258 0.835 rs7543228 chr1:7306538 G/C cg07173049 chr1:7289937 CAMTA1 0.41 10.1 0.37 2.32e-22 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg25817165 chr18:72167213 CNDP2 -0.73 -14.18 -0.49 6.77e-40 Refractive error; BRCA cis rs6905628 1 rs6905628 chr6:90344869 C/G cg23505970 chr6:90529759 MDN1 0.47 8.21 0.31 1.2e-15 Coronary artery disease; BRCA cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.89 0.36 1.54e-21 Bladder cancer; BRCA cis rs10242455 0.702 rs112475236 chr7:99044679 A/G cg18809830 chr7:99032528 PTCD1 -0.59 -8.57 -0.32 7.81e-17 Blood metabolite levels; BRCA cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg06713675 chr4:122721982 EXOSC9 -0.41 -10.28 -0.38 4.8e-23 Type 2 diabetes; BRCA cis rs273218 1.000 rs168861 chr5:53377310 T/C ch.5.1024479R chr5:53302184 ARL15 0.39 8.13 0.31 2.22e-15 Migraine; BRCA cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg11279151 chr3:101281821 RG9MTD1 -0.51 -10.6 -0.39 2.68e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1165668 0.816 rs1866072 chr12:104310706 C/G cg21863207 chr12:104234989 NT5DC3 0.39 8.05 0.3 4.1e-15 Coronary heart disease (SNP X SNP interaction); BRCA cis rs6545883 0.894 rs6545845 chr2:61437044 G/C cg15711740 chr2:61764176 XPO1 0.52 13.12 0.46 5.26e-35 Tuberculosis; BRCA trans rs61332075 0.518 rs72994950 chr2:239422993 T/C cg01134436 chr17:81009848 B3GNTL1 0.7 9.0 0.34 2.56e-18 Lung function (FEV1/FVC); BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg10729496 chr3:10149963 C3orf24 0.47 7.84 0.3 1.9e-14 Alzheimer's disease; BRCA trans rs634534 0.622 rs531612 chr11:65705432 C/T cg17712092 chr4:129076599 LARP1B -0.53 -12.8 -0.45 1.48e-33 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7618501 0.635 rs34080578 chr3:50026029 A/C cg24110177 chr3:50126178 RBM5 -0.37 -9.96 -0.37 7.85e-22 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.68 -0.42 1.1e-28 Electroencephalogram traits; BRCA cis rs10911363 0.592 rs2702177 chr1:183450622 G/C cg09173681 chr1:183549694 NCF2 0.49 10.7 0.39 1.05e-24 Systemic lupus erythematosus; BRCA trans rs9354352 0.935 rs9345749 chr6:66699892 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.54 -11.04 -0.4 4.88e-26 Initial pursuit acceleration in psychotic disorders; BRCA cis rs2153535 0.521 rs6939827 chr6:8461360 C/G cg21535247 chr6:8435926 SLC35B3 0.39 8.84 0.33 9.42e-18 Motion sickness; BRCA cis rs1949733 0.701 rs2631735 chr4:8476118 A/G cg11789530 chr4:8429930 ACOX3 0.58 13.76 0.48 6.38e-38 Response to antineoplastic agents; BRCA cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.93 0.56 2.07e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.818 rs441229 chr1:153015059 A/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.83 -0.33 1.04e-17 Inflammatory skin disease; BRCA cis rs7572733 0.515 rs1356542 chr2:198835702 G/T cg00792783 chr2:198669748 PLCL1 0.45 9.85 0.36 2.05e-21 Dermatomyositis; BRCA cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 1.000 rs10019856 chr4:17615742 T/A cg16339924 chr4:17578868 LAP3 0.64 16.0 0.53 1.01e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs614226 1.000 rs1167727 chr12:120965508 C/A cg27489772 chr12:121021490 NA 0.44 7.95 0.3 8.79e-15 Type 1 diabetes nephropathy; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg16145915 chr7:1198662 ZFAND2A -0.6 -14.29 -0.49 2.12e-40 Longevity;Endometriosis; BRCA cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.91 -0.3 1.14e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg06238570 chr21:40685208 BRWD1 0.41 8.4 0.32 2.96e-16 Cognitive function; BRCA cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg20887711 chr4:1340912 KIAA1530 0.74 16.36 0.54 1.59e-50 Longevity; BRCA cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.58 12.3 0.44 2.42e-31 Age-related macular degeneration (geographic atrophy); BRCA cis rs3931020 0.548 rs969435 chr1:75273866 A/G cg21906852 chr1:75198582 TYW3;CRYZ -0.45 -9.08 -0.34 1.28e-18 Resistin levels; BRCA cis rs3806843 1.000 rs10050455 chr5:140204650 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.97 -0.37 7.54e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs10465746 0.901 rs17475760 chr1:84398435 A/T cg10977910 chr1:84465055 TTLL7 0.49 9.8 0.36 3.17e-21 Obesity-related traits; BRCA trans rs262150 0.714 rs2657397 chr7:158785095 C/T cg21167628 chr1:45308625 PTCH2 -0.32 -7.95 -0.3 8.45e-15 Facial morphology (factor 20); BRCA cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg10523679 chr1:76189770 ACADM -0.44 -8.37 -0.31 3.71e-16 Daytime sleep phenotypes; BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg16431978 chr21:31797932 KRTAP13-3 0.36 9.05 0.34 1.71e-18 HDL cholesterol; BRCA cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg10560079 chr2:191398806 TMEM194B 0.37 8.24 0.31 9.67e-16 Pulse pressure; BRCA cis rs3862030 0.503 rs6584505 chr10:104254412 C/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.92 0.58 1.72e-58 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs6433895 1.000 rs12999974 chr2:182019537 G/A cg00481216 chr2:181971175 NA 0.4 9.18 0.34 5.9e-19 Lymphocyte counts; BRCA cis rs61931739 0.500 rs34061369 chr12:34519283 C/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs17604090 1.000 rs10272065 chr7:29694236 A/T cg19413766 chr7:29689036 LOC646762 -0.59 -7.95 -0.3 8.38e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs6570726 0.935 rs454614 chr6:145832633 C/T cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.866 rs72676074 chr4:120359841 A/C cg09307838 chr4:120376055 NA 0.77 17.16 0.56 1.49e-54 Corneal astigmatism; BRCA cis rs2070997 0.527 rs3847192 chr9:133724916 T/G cg11464064 chr9:133710261 ABL1 0.6 9.66 0.36 1.1e-20 Response to amphetamines; BRCA trans rs9858542 0.953 rs7646366 chr3:49470668 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.67 -0.36 9.61e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -8.0 -0.3 5.81e-15 Corneal astigmatism; BRCA cis rs57221529 0.713 rs12522724 chr5:590742 T/C cg09021430 chr5:549028 NA -0.65 -13.67 -0.48 1.7e-37 Lung disease severity in cystic fibrosis; BRCA cis rs4588572 0.643 rs1560195 chr5:77701913 A/G cg11547950 chr5:77652471 NA 0.46 8.37 0.31 3.71e-16 Triglycerides; BRCA cis rs1050631 0.564 rs8098627 chr18:33721636 T/G cg19453250 chr18:33710783 SLC39A6;ELP2 -0.29 -7.94 -0.3 9.24e-15 Esophageal squamous cell cancer (length of survival); BRCA cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.41 0.5 5.45e-41 Motion sickness; BRCA cis rs9790314 0.846 rs4856738 chr3:160986637 C/G cg04691961 chr3:161091175 C3orf57 -0.44 -10.69 -0.39 1.18e-24 Morning vs. evening chronotype; BRCA cis rs4363385 0.818 rs561143 chr1:153010734 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs775227 0.574 rs13083453 chr3:113096943 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -9.53 -0.35 3.24e-20 Dental caries; BRCA cis rs9443189 0.526 rs9359132 chr6:76289553 G/A cg01950844 chr6:76311363 SENP6 0.84 13.79 0.48 4.58e-38 Prostate cancer; BRCA cis rs9316337 0.933 rs1409071 chr13:21962773 C/T cg21011702 chr13:21951294 ZDHHC20 0.32 8.44 0.32 2.1e-16 Schizophrenia; BRCA cis rs6714710 0.603 rs11690687 chr2:98461821 C/T cg26665480 chr2:98280029 ACTR1B 0.55 12.92 0.46 4.45e-34 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs12618769 0.652 rs13402379 chr2:99209314 G/A cg10123293 chr2:99228465 UNC50 0.42 8.67 0.32 3.58e-17 Bipolar disorder; BRCA cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg24642439 chr20:33292090 TP53INP2 0.42 9.16 0.34 6.94e-19 Height; BRCA cis rs9467773 0.565 rs6925047 chr6:26521435 C/G cg09904177 chr6:26538194 HMGN4 0.46 12.69 0.45 4.59e-33 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg17971929 chr21:40555470 PSMG1 -0.61 -13.5 -0.47 1.03e-36 Cognitive function; BRCA cis rs3806843 1.000 rs12055222 chr5:140165568 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.53 -0.35 3.1e-20 Depressive symptoms (multi-trait analysis); BRCA trans rs12517041 1.000 rs16892325 chr5:23283742 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.24 -0.31 9.5e-16 Calcium levels; BRCA cis rs6964587 1.000 rs12539231 chr7:91634963 G/A cg17063962 chr7:91808500 NA 0.53 12.49 0.44 3.35e-32 Breast cancer; BRCA cis rs11920090 0.789 rs11711206 chr3:170732945 A/G cg09710316 chr3:170744871 SLC2A2 0.56 9.53 0.35 3.18e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg18765753 chr7:1198926 ZFAND2A -0.44 -10.1 -0.37 2.44e-22 Longevity;Endometriosis; BRCA cis rs17125944 0.505 rs118053951 chr14:53259829 G/A cg00686598 chr14:53173677 PSMC6 1.15 15.86 0.53 5.01e-48 Alzheimer's disease (late onset); BRCA cis rs7943191 0.810 rs7942991 chr11:62337203 A/G cg11742103 chr11:62369870 EML3;MTA2 -0.5 -10.78 -0.39 5.03e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs77106637 1.000 rs76793820 chr11:72619860 G/A cg03713592 chr11:72463424 ARAP1 0.8 11.92 0.43 1.05e-29 Type 2 diabetes; BRCA cis rs6582630 0.519 rs2387812 chr12:38381480 A/G cg26384229 chr12:38710491 ALG10B 0.69 16.12 0.54 2.66e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg00990874 chr7:1149470 C7orf50 -0.52 -9.49 -0.35 4.33e-20 Bronchopulmonary dysplasia; BRCA cis rs12549902 0.932 rs6981607 chr8:41508168 A/C cg21772509 chr8:41503840 NKX6-3 0.48 11.25 0.41 6.69e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs6500602 0.627 rs4786494 chr16:4506232 G/A cg08645402 chr16:4508243 NA 0.41 9.82 0.36 2.76e-21 Schizophrenia; BRCA cis rs6546550 0.901 rs6754896 chr2:70138170 T/C cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.93e-28 Prevalent atrial fibrillation; BRCA cis rs453301 0.686 rs10217044 chr8:8894752 A/G cg15556689 chr8:8085844 FLJ10661 -0.31 -8.15 -0.31 1.86e-15 Joint mobility (Beighton score); BRCA cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg13736514 chr6:26305472 NA -0.28 -9.34 -0.35 1.52e-19 Educational attainment; BRCA cis rs9814567 1.000 rs9871305 chr3:134213538 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.45 -0.61 1.55e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11722228 1.000 rs6823877 chr4:9921931 T/C cg00071950 chr4:10020882 SLC2A9 -0.41 -8.88 -0.33 6.7e-18 Gout;Urate levels;Serum uric acid levels; BRCA cis rs6910061 0.830 rs9468404 chr6:11092858 C/A cg27233058 chr6:11094804 LOC221710 0.5 8.43 0.32 2.36e-16 Diabetic kidney disease; BRCA cis rs2066819 1.000 rs2371454 chr12:56647243 A/G cg26714650 chr12:56694279 CS 1.18 15.55 0.52 1.84e-46 Psoriasis vulgaris; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg00149659 chr3:10157352 C3orf10 -1.05 -18.06 -0.58 3.29e-59 Alzheimer's disease; BRCA trans rs1994135 0.715 rs10844624 chr12:33691010 A/G cg26384229 chr12:38710491 ALG10B 0.49 10.01 0.37 4.99e-22 Resting heart rate; BRCA cis rs172166 0.694 rs1631552 chr6:28089699 C/A cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.01 0.3 5.6e-15 Cardiac Troponin-T levels; BRCA cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.85 0.33 8.6e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs12908161 0.515 rs12907646 chr15:85403496 G/A cg12863693 chr15:85201151 NMB 0.44 8.03 0.3 4.77e-15 Schizophrenia; BRCA cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.8 0.39 4.41e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1868673 1.000 rs4681619 chr3:150160253 G/A cg04908077 chr3:150187338 NA -0.33 -9.0 -0.34 2.56e-18 Waist circumference; BRCA cis rs4953076 0.573 rs6726680 chr2:44406686 C/G cg04920474 chr2:44395004 PPM1B 0.51 10.38 0.38 1.93e-23 Height; BRCA cis rs7633770 0.841 rs11709936 chr3:46680483 C/G cg11219411 chr3:46661640 NA 0.69 18.71 0.6 1.21e-62 Coronary artery disease; BRCA trans rs877282 0.898 rs11253350 chr10:765968 G/A cg22713356 chr15:30763199 NA 1.3 24.11 0.69 7.71e-92 Uric acid levels; BRCA cis rs6500602 0.626 rs7665 chr16:4562512 A/G cg08645402 chr16:4508243 NA 0.44 10.11 0.37 2.15e-22 Schizophrenia; BRCA cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg17971929 chr21:40555470 PSMG1 0.81 19.92 0.62 4.86e-69 Cognitive function; BRCA cis rs7772486 0.743 rs9390344 chr6:146012755 C/G cg23711669 chr6:146136114 FBXO30 -0.69 -16.63 -0.55 6.96e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs7520050 0.966 rs10890361 chr1:46346234 A/T cg24296786 chr1:45957014 TESK2 0.36 8.42 0.32 2.4e-16 Red blood cell count;Reticulocyte count; BRCA cis rs2303759 0.918 rs8107548 chr19:49870643 T/C cg22307029 chr19:49891270 CCDC155 0.57 9.77 0.36 4.09e-21 Multiple sclerosis; BRCA cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg19196401 chr6:110721138 DDO -0.41 -10.23 -0.38 7.46e-23 Platelet distribution width; BRCA cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg00012203 chr2:219082015 ARPC2 0.51 10.35 0.38 2.63e-23 Colorectal cancer; BRCA cis rs9487051 0.646 rs4548045 chr6:109576135 C/T cg01475377 chr6:109611718 NA -0.41 -8.13 -0.31 2.21e-15 Reticulocyte fraction of red cells; BRCA cis rs1008375 0.931 rs7435102 chr4:17571480 C/G cg04450456 chr4:17643702 FAM184B 0.41 11.95 0.43 7.41e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg21143896 chr7:2802374 GNA12 0.34 8.76 0.33 1.71e-17 Height; BRCA cis rs7408868 1.000 rs757475 chr19:15273749 C/T cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs9814567 0.806 rs7648616 chr3:134318074 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.580 rs4404802 chr6:8442052 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs36051895 0.623 rs3780382 chr9:5232299 G/A cg02405213 chr9:5042618 JAK2 -0.47 -8.9 -0.33 5.88e-18 Pediatric autoimmune diseases; BRCA cis rs35146811 0.735 rs1727139 chr7:99815367 C/T cg13334819 chr7:99746414 C7orf59 0.34 7.94 0.3 9.32e-15 Coronary artery disease; BRCA cis rs17270561 0.609 rs3778272 chr6:25767661 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs11719291 0.833 rs11713694 chr3:48833615 G/T cg00383909 chr3:49044727 WDR6 0.97 15.71 0.53 2.72e-47 Cognitive function; BRCA cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg11843238 chr5:131593191 PDLIM4 0.36 7.91 0.3 1.17e-14 Breast cancer; BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg24549020 chr5:56110836 MAP3K1 0.52 10.52 0.38 5.72e-24 Initial pursuit acceleration; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg09263875 chr16:632152 PIGQ 0.73 21.12 0.64 1.65e-75 Height; BRCA trans rs526821 0.574 rs11230156 chr11:55334809 A/G cg11707556 chr5:10655725 ANKRD33B -0.36 -7.91 -0.3 1.11e-14 Pediatric bone mineral density (spine); BRCA cis rs10911232 0.507 rs10911195 chr1:182993438 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.79 0.55 1.14e-52 Hypertriglyceridemia; BRCA cis rs700651 0.856 rs9288280 chr2:198744324 A/G cg00792783 chr2:198669748 PLCL1 0.46 10.14 0.37 1.66e-22 Intracranial aneurysm; BRCA cis rs2901460 0.527 rs10167456 chr2:62112839 G/A cg02183531 chr2:62113199 CCT4 -0.45 -9.17 -0.34 6.51e-19 Mean corpuscular volume; BRCA cis rs7647973 0.516 rs4536858 chr3:49193081 A/G cg06212747 chr3:49208901 KLHDC8B 0.54 11.79 0.42 3.7e-29 Menarche (age at onset); BRCA cis rs765787 0.530 rs12440238 chr15:45512905 T/C cg25801113 chr15:45476975 SHF -0.33 -8.3 -0.31 6.21e-16 Uric acid levels; BRCA cis rs651907 0.557 rs17411983 chr3:101399126 A/G cg12386194 chr3:101231763 SENP7 -0.45 -9.61 -0.36 1.6e-20 Colorectal cancer; BRCA trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.06 0.3 3.79e-15 Corneal astigmatism; BRCA cis rs11105298 0.891 rs10858909 chr12:89935387 C/T cg00757033 chr12:89920650 WDR51B 0.53 10.57 0.39 3.7e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs5758511 0.633 rs5751258 chr22:42663871 C/G cg00645731 chr22:42541494 CYP2D7P1 0.56 10.89 0.4 1.95e-25 Birth weight; BRCA cis rs6594713 0.717 rs10065790 chr5:112911165 C/T cg12552261 chr5:112820674 MCC 0.48 8.22 0.31 1.18e-15 Brain cytoarchitecture; BRCA cis rs2242116 0.592 rs2290545 chr3:46967040 C/T cg27129171 chr3:47204927 SETD2 0.57 10.36 0.38 2.27e-23 Birth weight; BRCA cis rs490234 0.683 rs2841326 chr9:128161768 G/A cg14078157 chr9:128172775 NA -0.36 -8.53 -0.32 1.05e-16 Mean arterial pressure; BRCA cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg01939980 chr4:1354348 KIAA1530 0.31 8.71 0.33 2.69e-17 Longevity; BRCA trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg15556689 chr8:8085844 FLJ10661 -0.32 -8.39 -0.32 3.22e-16 Neuroticism; BRCA cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg21475434 chr5:93447410 FAM172A 0.68 8.86 0.33 7.78e-18 Diabetic retinopathy; BRCA cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg16405210 chr4:1374714 KIAA1530 0.94 23.7 0.68 1.41e-89 Longevity; BRCA cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg25019033 chr10:957182 NA -0.41 -8.63 -0.32 4.83e-17 Eosinophil percentage of granulocytes; BRCA trans rs7618501 0.574 rs6765484 chr3:50041313 C/T cg21659725 chr3:3221576 CRBN -0.45 -11.07 -0.4 3.57e-26 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs1909508 chr7:65766353 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.63 0.39 2.12e-24 Aortic root size; BRCA cis rs2882667 0.861 rs13176902 chr5:138393329 T/C cg04439458 chr5:138467593 SIL1 -0.33 -9.01 -0.34 2.31e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs877282 0.853 rs12779017 chr10:763619 T/C cg17470449 chr10:769945 NA 0.47 7.92 0.3 1.08e-14 Uric acid levels; BRCA cis rs11792861 0.591 rs2275641 chr9:111696389 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 12.84 0.45 9.76e-34 Menarche (age at onset); BRCA cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg25817165 chr18:72167213 CNDP2 -0.77 -19.53 -0.61 5.84e-67 Refractive error; BRCA cis rs11105298 0.891 rs10506972 chr12:89861529 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.94 -0.37 9.36e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg21280719 chr6:42927975 GNMT -0.32 -13.8 -0.48 4.05e-38 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4820318 1 rs4820318 chr22:38570313 G/A cg25457927 chr22:38595422 NA -0.35 -12.65 -0.45 6.86e-33 Breast cancer; BRCA cis rs9296092 0.538 rs62407567 chr6:33537213 A/G cg13560919 chr6:33536144 NA -0.87 -16.36 -0.54 1.61e-50 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7980687 0.550 rs1727324 chr12:123698603 A/T cg00376283 chr12:123451042 ABCB9 0.55 10.54 0.38 4.47e-24 Height;Educational attainment;Head circumference (infant); BRCA cis rs7312933 0.737 rs10880261 chr12:42573822 T/C cg01256987 chr12:42539512 GXYLT1 -0.46 -9.22 -0.34 4.42e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs225245 0.687 rs321614 chr17:33881734 A/G cg08516792 chr17:33866067 SLFN12L 0.35 7.9 0.3 1.25e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg11062466 chr8:58055876 NA 0.5 8.74 0.33 2.04e-17 Developmental language disorder (linguistic errors); BRCA cis rs4302748 0.862 rs57007022 chr7:36187369 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.8 0.33 1.27e-17 Platelet count; BRCA cis rs853679 0.517 rs55747925 chr6:28044337 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.15e-15 Depression; BRCA cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11890956 chr21:40555474 PSMG1 1.05 29.86 0.76 2.64e-123 Cognitive function; BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg08470875 chr2:26401718 FAM59B 0.49 8.09 0.3 3.04e-15 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs10031751 chr4:98939134 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -8.59 -0.32 6.42e-17 Schizophrenia; BRCA cis rs28374715 0.578 rs17730888 chr15:41637547 A/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.89 -0.72 1.3e-101 Ulcerative colitis; BRCA cis rs6977660 0.505 rs9639338 chr7:19869778 T/A cg05791153 chr7:19748676 TWISTNB 0.49 9.41 0.35 8.92e-20 Thyroid stimulating hormone; BRCA cis rs7646881 1.000 rs59217052 chr3:158452456 C/T cg19483011 chr3:158453295 NA -0.49 -9.32 -0.35 1.81e-19 Tetralogy of Fallot; BRCA cis rs7582180 0.629 rs2164847 chr2:100958715 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.62 0.42 1.92e-28 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.647 rs2115597 chr2:227791218 T/C cg05526886 chr2:227700861 RHBDD1 -0.41 -8.55 -0.32 9.19e-17 Pulmonary function; BRCA trans rs6582630 0.502 rs11495393 chr12:38341194 T/C cg06521331 chr12:34319734 NA -0.45 -8.39 -0.32 3.03e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg04546413 chr19:29218101 NA 0.64 12.31 0.44 2.04e-31 Methadone dose in opioid dependence; BRCA cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg20203395 chr5:56204925 C5orf35 -0.49 -10.52 -0.38 5.5e-24 Initial pursuit acceleration; BRCA cis rs6430585 0.528 rs721765 chr2:136748779 C/A cg07169764 chr2:136633963 MCM6 1.22 23.89 0.69 1.27e-90 Corneal structure; BRCA cis rs7727544 0.606 rs200838 chr5:131710399 A/C cg14196790 chr5:131705035 SLC22A5 -0.5 -13.76 -0.48 6.66e-38 Blood metabolite levels; BRCA cis rs6570726 0.935 rs451349 chr6:145820894 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs3780486 0.846 rs7850878 chr9:33126570 A/G cg04842962 chr6:43655489 MRPS18A 1.12 38.52 0.84 1.01e-168 IgG glycosylation; BRCA cis rs2832077 1.000 rs12329875 chr21:30137796 C/T cg24692254 chr21:30365293 RNF160 -0.44 -7.89 -0.3 1.3e-14 Cognitive test performance; BRCA cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 14.46 0.5 3.43e-41 Alzheimer's disease; BRCA cis rs9733 0.596 rs2065900 chr1:150652202 A/G cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA trans rs6951245 0.507 rs11976805 chr7:1138716 C/T cg13565492 chr6:43139072 SRF -0.73 -13.47 -0.47 1.35e-36 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs6952808 0.510 rs13227554 chr7:2048220 G/C cg04565464 chr8:145669602 NFKBIL2 -0.36 -8.97 -0.33 3.31e-18 Bipolar disorder and schizophrenia; BRCA cis rs12048904 0.930 rs11166529 chr1:101333733 C/T cg15686842 chr1:101360669 SLC30A7;EXTL2 0.34 7.83 0.3 2e-14 Multiple sclerosis; BRCA cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg06713675 chr4:122721982 EXOSC9 -0.54 -12.5 -0.44 3.1e-32 Type 2 diabetes; BRCA cis rs9837602 0.748 rs9875878 chr3:99884509 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 8.57 0.32 7.74e-17 Breast cancer; BRCA cis rs4727443 0.691 rs6975827 chr7:99585798 C/G cg22004693 chr7:99632812 ZKSCAN1 -0.38 -8.51 -0.32 1.24e-16 Interstitial lung disease; BRCA cis rs9381040 0.655 rs2294695 chr6:41036770 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.74 -0.36 5.51e-21 Alzheimer's disease (late onset); BRCA cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg05294307 chr14:35346193 BAZ1A -0.6 -11.71 -0.42 8.13e-29 Psoriasis; BRCA cis rs514406 0.505 rs269287 chr1:53168842 T/C cg24675658 chr1:53192096 ZYG11B -0.61 -14.21 -0.49 5.18e-40 Monocyte count; BRCA cis rs4319547 0.508 rs10846826 chr12:122894987 C/T cg23029597 chr12:123009494 RSRC2 -0.6 -11.69 -0.42 9.17e-29 Body mass index; BRCA cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg16262614 chr3:133464971 TF 0.25 8.02 0.3 5.02e-15 Iron status biomarkers (transferrin levels); BRCA cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg06784218 chr1:46089804 CCDC17 0.44 10.51 0.38 5.97e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2204008 0.905 rs7294297 chr12:38442573 T/C cg13010199 chr12:38710504 ALG10B 0.4 8.34 0.31 4.52e-16 Bladder cancer; BRCA cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg20203395 chr5:56204925 C5orf35 0.43 9.56 0.35 2.43e-20 Initial pursuit acceleration; BRCA cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg06618935 chr21:46677482 NA -0.36 -8.0 -0.3 5.66e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs478304 0.651 rs7110576 chr11:65512057 T/G cg10518572 chr11:65560635 OVOL1 -0.28 -8.1 -0.31 2.71e-15 Acne (severe); BRCA cis rs17270561 0.609 rs9358877 chr6:25739228 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.8 0.33 1.28e-17 Iron status biomarkers; BRCA cis rs7945705 0.902 rs10769980 chr11:9014180 G/A cg12365402 chr11:9010492 NRIP3 0.43 9.5 0.35 4.24e-20 Hemoglobin concentration; BRCA cis rs524281 0.692 rs2302884 chr11:65824084 C/T cg14036092 chr11:66035641 RAB1B -0.41 -8.98 -0.33 2.89e-18 Electroencephalogram traits; BRCA cis rs2243480 1.000 rs6958289 chr7:65657111 T/G cg18252515 chr7:66147081 NA 1.05 15.84 0.53 6.5e-48 Diabetic kidney disease; BRCA cis rs2239547 0.522 rs7652131 chr3:52997154 C/T cg18404041 chr3:52824283 ITIH1 -0.3 -7.82 -0.3 2.26e-14 Schizophrenia; BRCA cis rs11105298 0.891 rs10777184 chr12:89919568 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.53 -0.35 3.25e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg11905131 chr22:24372483 LOC391322 -0.54 -11.91 -0.43 1.07e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4595586 0.545 rs1607042 chr12:39368028 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs9807989 0.507 rs10439410 chr2:102990788 A/C cg03938978 chr2:103052716 IL18RAP -0.29 -8.45 -0.32 1.9e-16 Asthma; BRCA cis rs6142102 0.961 rs2284386 chr20:32644396 G/A cg24642439 chr20:33292090 TP53INP2 0.41 8.01 0.3 5.34e-15 Skin pigmentation; BRCA trans rs4332037 0.522 rs4721098 chr7:1881527 G/C cg25206134 chr2:45395956 NA -0.53 -8.88 -0.33 6.74e-18 Bipolar disorder; BRCA cis rs8180040 0.654 rs11714373 chr3:47214817 G/A cg16586182 chr3:47516702 SCAP 0.56 12.68 0.45 5.17e-33 Colorectal cancer; BRCA cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg00080972 chr5:178986291 RUFY1 0.53 14.71 0.5 2.12e-42 Lung cancer; BRCA cis rs10465746 0.747 rs10493741 chr1:84388118 G/C cg10977910 chr1:84465055 TTLL7 0.58 11.96 0.43 6.85e-30 Obesity-related traits; BRCA cis rs1371614 0.502 rs4572551 chr2:27194013 T/C cg00617064 chr2:27272375 NA -0.33 -8.62 -0.32 5.09e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg04756594 chr16:24857601 SLC5A11 -0.53 -12.2 -0.43 6.31e-31 Intelligence (multi-trait analysis); BRCA cis rs2011503 1.000 rs4808205 chr19:19645493 T/G cg11584989 chr19:19387371 SF4 0.64 13.48 0.47 1.26e-36 Bipolar disorder; BRCA cis rs829883 0.902 rs829884 chr12:98879500 C/G cg25150519 chr12:98850993 NA 0.58 11.77 0.42 4.21e-29 Colorectal adenoma (advanced); BRCA cis rs1577917 1.000 rs1962716 chr6:86648436 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -12.98 -0.46 2.27e-34 Response to antipsychotic treatment; BRCA cis rs875971 0.638 rs801216 chr7:66011667 T/C cg18876405 chr7:65276391 NA -0.62 -15.48 -0.52 4.02e-46 Aortic root size; BRCA cis rs514406 0.929 rs564273 chr1:53332445 G/C cg16325326 chr1:53192061 ZYG11B 0.7 16.97 0.56 1.39e-53 Monocyte count; BRCA cis rs7772486 0.806 rs4243478 chr6:146284560 A/G cg23711669 chr6:146136114 FBXO30 -0.68 -15.6 -0.53 9.68e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg05283184 chr6:79620031 NA -0.43 -11.0 -0.4 6.5e-26 Intelligence (multi-trait analysis); BRCA cis rs11719291 0.833 rs11715835 chr3:48770732 C/T cg01304814 chr3:48885189 PRKAR2A 0.67 7.82 0.3 2.15e-14 Cognitive function; BRCA cis rs9649213 0.586 rs55648546 chr7:97960800 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.59 -15.77 -0.53 1.53e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg04450456 chr4:17643702 FAM184B 0.33 9.65 0.36 1.15e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6028335 0.674 rs66513266 chr20:37597410 G/T cg16355469 chr20:37678765 NA 0.46 8.2 0.31 1.29e-15 Alcohol and nicotine co-dependence; BRCA cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg10792982 chr14:105748885 BRF1 0.44 10.4 0.38 1.7e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs921968 0.565 rs7594046 chr2:219624170 A/G cg02176678 chr2:219576539 TTLL4 0.41 11.04 0.4 4.83e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs61931739 0.500 rs7311302 chr12:34557211 T/C cg06521331 chr12:34319734 NA -0.52 -10.27 -0.38 5.25e-23 Morning vs. evening chronotype; BRCA cis rs7011049 1.000 rs11995106 chr8:53834768 C/T cg26025543 chr8:53854495 NA 0.54 9.86 0.36 1.85e-21 Systolic blood pressure; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg15112475 chr7:1198522 ZFAND2A -0.56 -13.3 -0.47 8.33e-36 Longevity;Endometriosis; BRCA trans rs9291683 0.668 rs2241474 chr4:10086015 T/C cg26043149 chr18:55253948 FECH 0.43 9.34 0.35 1.58e-19 Bone mineral density; BRCA cis rs7584330 0.740 rs7586312 chr2:238439389 G/A cg14458575 chr2:238380390 NA 0.39 8.62 0.32 5.43e-17 Prostate cancer; BRCA cis rs7904985 0.924 rs2217223 chr10:88111630 A/G cg07322936 chr10:88137208 NA 0.49 10.34 0.38 2.86e-23 Barrett's esophagus; BRCA cis rs79839061 0.610 rs11732965 chr4:869359 C/A cg23992470 chr4:843637 GAK 0.55 8.19 0.31 1.42e-15 Intelligence (multi-trait analysis); BRCA cis rs11676348 0.846 rs4674257 chr2:218988774 A/G cg06547715 chr2:218990976 CXCR2 0.32 7.96 0.3 7.76e-15 Ulcerative colitis; BRCA cis rs2629540 0.889 rs10901808 chr10:126399159 A/C cg08799069 chr10:126477246 METTL10 0.45 9.15 0.34 7.66e-19 Cocaine dependence; BRCA cis rs2197308 0.740 rs1842595 chr12:37906223 G/A cg26384229 chr12:38710491 ALG10B -0.58 -13.45 -0.47 1.65e-36 Morning vs. evening chronotype; BRCA cis rs4478858 0.735 rs10798843 chr1:31797094 A/G cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -8.81 -0.33 1.18e-17 Bipolar disorder and schizophrenia; BRCA cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg08885076 chr2:99613938 TSGA10 0.44 10.13 0.37 1.76e-22 Chronic sinus infection; BRCA cis rs4588572 0.570 rs6453389 chr5:77727003 T/G cg11547950 chr5:77652471 NA -0.44 -8.41 -0.32 2.75e-16 Triglycerides; BRCA cis rs7631605 0.625 rs11718848 chr3:37366459 C/A cg15934958 chr3:37212084 LRRFIP2 0.38 8.11 0.31 2.61e-15 Cerebrospinal P-tau181p levels; BRCA cis rs894734 0.567 rs7138907 chr12:54324576 C/T cg25024717 chr12:54324583 NA -0.3 -7.96 -0.3 7.92e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); BRCA cis rs2153535 0.580 rs6421948 chr6:8531020 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.23e-23 Motion sickness; BRCA cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg11764359 chr7:65958608 NA 0.63 13.68 0.48 1.54e-37 Aortic root size; BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg27588902 chr6:42928151 GNMT -0.3 -10.13 -0.37 1.77e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg01448562 chr3:133502909 NA -0.63 -15.06 -0.51 4.14e-44 Iron status biomarkers; BRCA cis rs7917772 0.560 rs7912339 chr10:104373758 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.31 0.49 1.79e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs936229 0.813 rs7085 chr15:75095483 T/C cg14664628 chr15:75095509 CSK -0.95 -29.16 -0.76 1.67e-119 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs9487051 0.836 rs9487036 chr6:109607449 C/T cg21918786 chr6:109611834 NA -0.49 -14.13 -0.49 1.19e-39 Reticulocyte fraction of red cells; BRCA cis rs7677751 0.806 rs4864858 chr4:55089953 T/A cg17187183 chr4:55093834 PDGFRA 0.44 9.17 0.34 6.18e-19 Corneal astigmatism; BRCA cis rs6500602 0.623 rs9929311 chr16:4510426 T/C cg08645402 chr16:4508243 NA 0.47 10.77 0.39 5.59e-25 Schizophrenia; BRCA cis rs507080 0.922 rs638805 chr11:118558889 G/T cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA cis rs6831352 0.918 rs17218239 chr4:100057020 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA trans rs12579753 0.879 rs12579544 chr12:82164043 A/C cg07923666 chr12:49932857 KCNH3 -0.39 -7.84 -0.3 1.88e-14 Resting heart rate; BRCA trans rs7647973 0.710 rs6446284 chr3:49616997 A/G cg21659725 chr3:3221576 CRBN -0.49 -8.5 -0.32 1.31e-16 Menarche (age at onset); BRCA cis rs7809950 1.000 rs2520260 chr7:107172794 A/G cg23024343 chr7:107201750 COG5 -0.39 -9.03 -0.34 2.06e-18 Coronary artery disease; BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg26314531 chr2:26401878 FAM59B 0.93 14.99 0.51 9.06e-44 Gut microbiome composition (summer); BRCA trans rs208520 0.690 rs12201156 chr6:66720874 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 19.86 0.62 9.99e-69 Exhaled nitric oxide output; BRCA cis rs36051895 0.695 rs10974915 chr9:5016818 A/G cg02405213 chr9:5042618 JAK2 -0.45 -8.4 -0.32 2.83e-16 Pediatric autoimmune diseases; BRCA cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.54 -0.52 1.92e-46 Systemic lupus erythematosus; BRCA cis rs10463316 0.894 rs7719630 chr5:150760961 C/T cg03212797 chr5:150827313 SLC36A1 -0.42 -8.24 -0.31 1.01e-15 Metabolite levels (Pyroglutamine); BRCA cis rs2243480 1.000 rs35058610 chr7:65390925 G/A cg18252515 chr7:66147081 NA -0.84 -12.14 -0.43 1.2e-30 Diabetic kidney disease; BRCA cis rs3768617 0.510 rs1413387 chr1:183096774 G/A ch.1.3577855R chr1:183094577 LAMC1 0.62 15.95 0.53 1.88e-48 Fuchs's corneal dystrophy; BRCA cis rs3857067 0.806 rs7654565 chr4:95112939 G/T cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs10751667 0.666 rs12295141 chr11:947065 G/A cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.38e-33 Alzheimer's disease (late onset); BRCA cis rs1401999 0.966 rs2139560 chr3:183653869 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.14 0.37 1.6e-22 Anterior chamber depth; BRCA cis rs6460942 0.597 rs13245635 chr7:12526454 T/A cg06484146 chr7:12443880 VWDE -0.6 -7.85 -0.3 1.8e-14 Coronary artery disease; BRCA cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg26647111 chr11:31128758 NA 0.45 9.71 0.36 7.27e-21 Red blood cell count; BRCA cis rs35110281 0.811 rs4819264 chr21:45017349 G/T cg21573476 chr21:45109991 RRP1B -0.36 -9.19 -0.34 5.66e-19 Mean corpuscular volume; BRCA cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg20476274 chr7:133979776 SLC35B4 0.63 18.07 0.58 3.03e-59 Mean platelet volume; BRCA cis rs758324 0.947 rs924434 chr5:131143369 A/C cg06307176 chr5:131281290 NA 0.54 10.78 0.39 5.26e-25 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1865760 0.827 rs9461227 chr6:25960815 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.38e-21 Height; BRCA cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg02175503 chr12:58329896 NA 0.61 14.45 0.5 3.63e-41 Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 -0.82 -13.59 -0.47 4.07e-37 Platelet count; BRCA cis rs922182 0.617 rs28737203 chr15:64241169 C/T cg24729988 chr15:64271149 DAPK2 0.49 10.72 0.39 9.37e-25 Blood protein levels; BRCA trans rs12517041 1.000 rs1428620 chr5:23283138 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg27170947 chr2:26402098 FAM59B 0.77 11.01 0.4 6.14e-26 Gut microbiome composition (summer); BRCA cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg04267008 chr7:1944627 MAD1L1 -0.45 -9.79 -0.36 3.44e-21 Schizophrenia; BRCA cis rs477692 0.685 rs534430 chr10:131398734 A/C cg24747557 chr10:131355152 MGMT -0.4 -10.04 -0.37 3.98e-22 Response to temozolomide; BRCA cis rs10876993 0.855 rs10877007 chr12:58100058 T/A cg18357645 chr12:58087776 OS9 0.46 13.11 0.46 6.25e-35 Celiac disease or Rheumatoid arthritis; BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg20203395 chr5:56204925 C5orf35 -0.52 -10.59 -0.39 2.92e-24 Initial pursuit acceleration; BRCA cis rs2841277 0.708 rs10083374 chr14:105402994 T/C cg19901468 chr14:105411992 AHNAK2 -0.51 -12.48 -0.44 3.82e-32 Rheumatoid arthritis; BRCA cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg24229701 chr12:130821962 PIWIL1 0.39 8.89 0.33 6.08e-18 Menopause (age at onset); BRCA cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.75 12.1 0.43 1.72e-30 Mean platelet volume; BRCA cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg20701182 chr2:24300061 SF3B14 0.69 13.13 0.46 4.96e-35 Lymphocyte counts; BRCA cis rs4975709 0.589 rs4975707 chr5:1864028 C/T cg20790798 chr5:1857306 NA -0.37 -8.88 -0.33 6.68e-18 Cardiovascular disease risk factors; BRCA cis rs11809207 0.523 rs2783706 chr1:26504697 A/G cg00147160 chr1:26503991 CNKSR1 0.29 9.39 0.35 1e-19 Height; BRCA cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.89e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2303759 0.676 rs10426452 chr19:49907690 G/A cg22307029 chr19:49891270 CCDC155 0.56 10.41 0.38 1.53e-23 Multiple sclerosis; BRCA trans rs6582630 0.519 rs11182021 chr12:38443709 A/T cg06521331 chr12:34319734 NA 0.46 9.09 0.34 1.22e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -8.0 -0.3 5.87e-15 Longevity;Endometriosis; BRCA cis rs3862260 0.509 rs10923879 chr1:120163831 A/G cg16322792 chr1:120165303 ZNF697 0.58 15.43 0.52 6.54e-46 Systemic lupus erythematosus; BRCA cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg16405210 chr4:1374714 KIAA1530 -0.91 -20.96 -0.64 1.29e-74 Longevity; BRCA trans rs1005277 0.579 rs2474571 chr10:38384639 T/G cg23533926 chr12:111358616 MYL2 -0.41 -8.58 -0.32 7.18e-17 Extrinsic epigenetic age acceleration; BRCA cis rs17376456 0.825 rs10072232 chr5:93398890 G/A cg21475434 chr5:93447410 FAM172A 0.69 8.65 0.32 4.2e-17 Diabetic retinopathy; BRCA trans rs6582630 0.502 rs11181210 chr12:38298069 G/A cg06521331 chr12:34319734 NA -0.47 -8.73 -0.33 2.28e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs6430585 0.583 rs730005 chr2:136582694 T/C cg07169764 chr2:136633963 MCM6 1.32 32.61 0.79 4.13e-138 Corneal structure; BRCA cis rs17711722 0.510 rs73142128 chr7:65331109 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.65 14.26 0.49 2.84e-40 Calcium levels; BRCA cis rs7246657 0.943 rs8109632 chr19:37931125 A/T cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs1801251 0.963 rs13424351 chr2:233573629 A/G cg08000102 chr2:233561755 GIGYF2 0.56 12.05 0.43 2.81e-30 Coronary artery disease; BRCA cis rs7927771 0.524 rs7939420 chr11:47723938 A/G cg20307385 chr11:47447363 PSMC3 -0.39 -9.01 -0.34 2.44e-18 Subjective well-being; BRCA cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg02659138 chr7:134003124 SLC35B4 0.35 9.98 0.37 6.79e-22 Mean platelet volume; BRCA cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg19077165 chr18:44547161 KATNAL2 0.37 7.81 0.3 2.39e-14 Personality dimensions; BRCA cis rs8010715 0.816 rs11574503 chr14:24601318 C/G cg23112188 chr14:24563095 PCK2 0.32 8.06 0.3 3.82e-15 IgG glycosylation; BRCA cis rs2880765 0.835 rs12708553 chr15:86046833 C/G cg10818794 chr15:86012489 AKAP13 0.3 8.38 0.31 3.47e-16 Coronary artery disease; BRCA cis rs2073499 1.000 rs10510755 chr3:50281168 C/T cg05260129 chr3:50388622 TUSC4;CYB561D2 0.62 8.73 0.33 2.29e-17 Schizophrenia; BRCA trans rs9325144 0.647 rs11169258 chr12:39113040 C/T cg23762105 chr12:34175262 ALG10 0.35 8.05 0.3 3.92e-15 Morning vs. evening chronotype; BRCA cis rs921968 0.565 rs13408427 chr2:219628389 C/T cg02176678 chr2:219576539 TTLL4 -0.42 -11.2 -0.41 1e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg09436375 chr6:42928200 GNMT -0.29 -10.93 -0.4 1.36e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11674184 0.659 rs59129126 chr2:11728388 T/C cg07314298 chr2:11723111 GREB1 -0.8 -19.77 -0.62 2.91e-68 Endometriosis; BRCA cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg20701182 chr2:24300061 SF3B14 0.71 13.24 0.46 1.62e-35 Lymphocyte counts; BRCA cis rs7264396 0.836 rs6058276 chr20:34187728 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -12.05 -0.43 2.88e-30 Total cholesterol levels; BRCA cis rs17401966 0.838 rs4846207 chr1:10313811 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.7 0.48 1.21e-37 Hepatocellular carcinoma; BRCA cis rs9790314 0.586 rs1839491 chr3:161126429 C/A cg03342759 chr3:160939853 NMD3 -0.63 -14.06 -0.49 2.6e-39 Morning vs. evening chronotype; BRCA cis rs12760731 0.720 rs71628282 chr1:178449993 C/G cg00404053 chr1:178313656 RASAL2 0.69 8.6 0.32 6.18e-17 Obesity-related traits; BRCA cis rs2204008 0.774 rs7959048 chr12:37948276 T/A cg26384229 chr12:38710491 ALG10B 0.7 15.72 0.53 2.55e-47 Bladder cancer; BRCA cis rs897080 0.552 rs1067378 chr2:44648047 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.68 0.36 8.88e-21 Height; BRCA cis rs977987 0.806 rs2865531 chr16:75390316 T/A cg03315344 chr16:75512273 CHST6 0.53 12.64 0.45 7.21e-33 Dupuytren's disease; BRCA cis rs13108904 0.517 rs13128825 chr4:1334007 G/A cg00684032 chr4:1343700 KIAA1530 0.51 12.26 0.44 3.52e-31 Obesity-related traits; BRCA cis rs11105298 0.891 rs10858869 chr12:89857611 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -9.95 -0.37 8.92e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs34779708 0.931 rs4934524 chr10:35270921 G/C cg03585969 chr10:35415529 CREM 0.55 11.23 0.41 7.64e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10089 1.000 rs72794401 chr5:127517626 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 14.33 0.49 1.4e-40 Ileal carcinoids; BRCA cis rs11249608 0.548 rs2132671 chr5:178457434 A/G cg21905437 chr5:178450457 ZNF879 -0.51 -10.6 -0.39 2.61e-24 Pubertal anthropometrics; BRCA cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg03425785 chr20:62221387 GMEB2 0.51 8.17 0.31 1.6e-15 Glioblastoma; BRCA cis rs11809207 0.523 rs2802343 chr1:26498570 T/C cg00147160 chr1:26503991 CNKSR1 0.28 9.24 0.34 3.71e-19 Height; BRCA cis rs7395581 0.959 rs326222 chr11:47259668 A/G cg25783544 chr11:47291846 MADD -0.38 -8.31 -0.31 5.84e-16 HDL cholesterol; BRCA cis rs1215050 0.791 rs11729826 chr4:98657190 G/T cg05340658 chr4:99064831 C4orf37 -0.44 -9.97 -0.37 7.4e-22 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs3749237 1.000 rs2307021 chr3:49765483 C/G cg21659725 chr3:3221576 CRBN 0.5 11.29 0.41 4.35e-27 Resting heart rate; BRCA cis rs2066819 1.000 rs79436528 chr12:56686997 C/T cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs6545883 0.929 rs2264100 chr2:61670829 G/A cg15711740 chr2:61764176 XPO1 -0.56 -14.22 -0.49 4.62e-40 Tuberculosis; BRCA cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg24692254 chr21:30365293 RNF160 0.49 10.84 0.39 3e-25 Pancreatic cancer; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.64 -13.69 -0.48 1.4e-37 Lymphocyte counts; BRCA cis rs6964587 1.000 rs61244255 chr7:91751662 C/T cg01689657 chr7:91764605 CYP51A1 0.24 8.77 0.33 1.56e-17 Breast cancer; BRCA cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg24006582 chr15:45444508 DUOX1 0.56 11.12 0.4 2.28e-26 Uric acid levels; BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.34 0.35 1.5700000000000001e-19 Alzheimer's disease; BRCA cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg02551604 chr5:131831745 NA 0.39 14.32 0.49 1.46e-40 Asthma (sex interaction); BRCA cis rs17095355 1.000 rs72828241 chr10:111744704 T/A cg00817464 chr10:111662876 XPNPEP1 -0.43 -9.14 -0.34 8.28e-19 Biliary atresia; BRCA cis rs490234 0.841 rs536861 chr9:128313444 A/C cg14078157 chr9:128172775 NA 0.34 8.11 0.31 2.66e-15 Mean arterial pressure; BRCA cis rs1371614 0.545 rs13035643 chr2:27173341 G/A cg00617064 chr2:27272375 NA 0.31 8.07 0.3 3.62e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg14844989 chr11:31128820 NA 0.45 9.52 0.35 3.5e-20 Red blood cell count; BRCA cis rs4730250 0.707 rs257387 chr7:106808480 G/A cg02696742 chr7:106810147 HBP1 -0.61 -9.62 -0.36 1.49e-20 Osteoarthritis; BRCA trans rs1422110 0.513 rs1363264 chr5:85450380 G/C cg01787110 chr1:109008453 NBPF6 0.37 8.16 0.31 1.76e-15 Attention function in attention deficit hyperactive disorder; BRCA trans rs12517041 1.000 rs34069672 chr5:23281789 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.33 -0.31 4.92e-16 Calcium levels; BRCA trans rs11098499 0.863 rs6534139 chr4:120449456 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.36 -8.13 -0.31 2.25e-15 Corneal astigmatism; BRCA cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg23992470 chr4:843637 GAK 0.48 8.12 0.31 2.32e-15 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg05347473 chr6:146136440 FBXO30 0.44 8.7 0.33 2.8e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 22.12 0.66 5.79e-81 Platelet count; BRCA cis rs911555 0.713 rs10162425 chr14:103931621 C/T cg24130564 chr14:104152367 KLC1 -0.39 -8.79 -0.33 1.33e-17 Intelligence (multi-trait analysis); BRCA cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg00321850 chr1:175162397 KIAA0040 -0.41 -11.47 -0.41 8.16e-28 Alcohol dependence; BRCA cis rs72615157 0.539 rs2261360 chr7:99692993 G/T cg22004693 chr7:99632812 ZKSCAN1 0.53 11.04 0.4 4.49e-26 Lung function (FEV1/FVC); BRCA cis rs11608355 0.705 rs6663 chr12:109886603 G/A cg05360138 chr12:110035743 NA 0.45 8.55 0.32 8.76e-17 Neuroticism; BRCA cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.39 0.59 5.96e-61 Schizophrenia; BRCA cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg23262073 chr20:60523788 NA 0.4 8.6 0.32 6.05e-17 Body mass index; BRCA cis rs9790314 1.000 rs28515190 chr3:161028605 G/A cg04691961 chr3:161091175 C3orf57 -0.58 -14.01 -0.48 4.43e-39 Morning vs. evening chronotype; BRCA cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg03433033 chr1:76189801 ACADM 0.7 13.81 0.48 3.94e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.33 0.61 6.67e-66 Smoking behavior; BRCA cis rs1003719 0.628 rs2252402 chr21:38520720 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.52 11.01 0.4 6.36e-26 Eye color traits; BRCA cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg04586622 chr2:25135609 ADCY3 0.43 10.7 0.39 1.13e-24 Body mass index; BRCA trans rs2204008 0.837 rs2892296 chr12:37969785 C/T cg06521331 chr12:34319734 NA 0.44 8.74 0.33 2.07e-17 Bladder cancer; BRCA cis rs208520 0.874 rs208456 chr6:66907942 A/G cg07460842 chr6:66804631 NA -0.89 -15.26 -0.52 4.77e-45 Exhaled nitric oxide output; BRCA cis rs17401966 0.838 rs2105212 chr1:10281012 T/C cg03954927 chr1:10346856 KIF1B 0.41 12.97 0.46 2.59e-34 Hepatocellular carcinoma; BRCA trans rs11098499 0.954 rs17046116 chr4:120387259 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs2425143 1.000 rs6058311 chr20:34321895 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.0 -0.34 2.6e-18 Blood protein levels; BRCA cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.51 -0.44 2.97e-32 Bipolar disorder; BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.76 16.9 0.56 2.89e-53 Lymphocyte counts; BRCA trans rs11039798 0.511 rs7948129 chr11:48167828 G/A cg15704280 chr7:45808275 SEPT13 -0.5 -8.25 -0.31 9.2e-16 Axial length; BRCA cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1.01e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4642101 0.855 rs9836128 chr3:12845426 G/C cg24848339 chr3:12840334 CAND2 0.41 10.56 0.39 3.86e-24 QRS complex (12-leadsum); BRCA cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg24642439 chr20:33292090 TP53INP2 -0.53 -11.24 -0.41 6.91e-27 Glomerular filtration rate (creatinine); BRCA cis rs501916 0.634 rs61333299 chr15:48066806 G/A cg16110827 chr15:48056943 SEMA6D -0.42 -8.67 -0.32 3.56e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs72792276 0.818 rs3805610 chr5:127487719 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.54 9.29 0.35 2.34e-19 Red cell distribution width; BRCA cis rs7851660 0.967 rs7043885 chr9:100596439 C/T cg13688889 chr9:100608707 NA -0.37 -8.78 -0.33 1.52e-17 Strep throat; BRCA cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg19784903 chr17:45786737 TBKBP1 0.33 7.97 0.3 7.06e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1997103 1.000 rs9642580 chr7:55400359 G/A cg17469321 chr7:55412551 NA 0.49 9.25 0.34 3.45e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs11051970 0.838 rs2651369 chr12:32552769 C/G cg02745156 chr12:32552066 NA 0.29 9.28 0.34 2.64e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs1008375 1.000 rs7654345 chr4:17691796 A/G cg04450456 chr4:17643702 FAM184B 0.32 9.34 0.35 1.5700000000000001e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg19901468 chr14:105411992 AHNAK2 -0.51 -12.43 -0.44 6.12e-32 Rheumatoid arthritis; BRCA trans rs9784649 0.760 rs17403440 chr5:25054004 C/T cg11038491 chr20:34638489 LOC647979 -0.5 -9.62 -0.36 1.48e-20 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs12220238 0.818 rs10824082 chr10:75904080 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.5 8.22 0.31 1.11e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg06627628 chr2:24431161 ITSN2 -0.56 -9.13 -0.34 8.8e-19 Lymphocyte counts; BRCA cis rs523522 0.673 rs643372 chr12:121022640 C/G cg27279351 chr12:120934652 DYNLL1 0.56 13.4 0.47 2.91e-36 High light scatter reticulocyte count; BRCA cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg18876405 chr7:65276391 NA 0.54 12.64 0.45 7.84e-33 Aortic root size; BRCA trans rs6076960 0.684 rs3909041 chr20:6249598 C/G cg17788362 chr6:86352627 SYNCRIP 0.4 7.85 0.3 1.82e-14 Smooth-surface caries; BRCA cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.83 -0.39 3.18e-25 Personality dimensions; BRCA cis rs7945705 0.902 rs2012696 chr11:8995818 A/C cg21881798 chr11:8931708 C11orf17;ST5 0.61 13.42 0.47 2.47e-36 Hemoglobin concentration; BRCA cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg01262667 chr19:19385393 TM6SF2 -0.42 -10.65 -0.39 1.71e-24 Tonsillectomy; BRCA cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg06115741 chr20:33292138 TP53INP2 0.44 9.64 0.36 1.29e-20 Coronary artery disease; BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.79 0.42 3.64e-29 Tonsillectomy; BRCA cis rs7474896 0.559 rs2753880 chr10:38173338 G/A cg25427524 chr10:38739819 LOC399744 0.59 11.0 0.4 6.67e-26 Obesity (extreme); BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg05457628 chr5:178986728 RUFY1 -0.57 -14.53 -0.5 1.6e-41 Lung cancer; BRCA cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg04166393 chr7:2884313 GNA12 0.63 13.58 0.47 4.3e-37 Height; BRCA cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg01475377 chr6:109611718 NA -0.51 -12.98 -0.46 2.34e-34 Reticulocyte fraction of red cells; BRCA cis rs853679 0.517 rs9295761 chr6:28147987 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.99 0.3 6.41e-15 Depression; BRCA cis rs6450176 0.625 rs3776725 chr5:53290138 C/A ch.5.1024479R chr5:53302184 ARL15 -0.68 -15.14 -0.51 1.74e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs12543645 0.598 rs17767186 chr8:10277494 C/T cg06636001 chr8:8085503 FLJ10661 0.46 8.88 0.33 6.78e-18 Schizophrenia; BRCA cis rs2806561 0.929 rs10917357 chr1:23535161 C/T cg12483005 chr1:23474871 LUZP1 0.37 7.93 0.3 1.01e-14 Height; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg00106254 chr7:1943704 MAD1L1 -0.44 -11.68 -0.42 1.06e-28 Bipolar disorder and schizophrenia; BRCA cis rs7267979 1.000 rs2027003 chr20:25350498 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs28735056 0.904 rs11520415 chr18:77620620 C/T cg05926928 chr17:57297772 GDPD1 0.4 8.02 0.3 5.02e-15 Schizophrenia; BRCA cis rs10751667 0.643 rs7396046 chr11:937176 T/C cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg05863683 chr7:1912471 MAD1L1 0.4 8.53 0.32 1.04e-16 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.93 0.3 9.65e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.53 0.47 7.03e-37 Platelet count; BRCA cis rs4594175 0.962 rs7157823 chr14:51633170 C/T cg23942311 chr14:51606299 NA 0.33 8.32 0.31 5.22e-16 Cancer; BRCA cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.53 7.89 0.3 1.35e-14 Cerebrospinal P-tau181p levels; BRCA cis rs17401966 1.000 rs12136376 chr1:10296452 C/T cg15208524 chr1:10270712 KIF1B 0.37 8.24 0.31 9.770000000000001e-16 Hepatocellular carcinoma; BRCA cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg20476274 chr7:133979776 SLC35B4 0.6 14.74 0.5 1.56e-42 Mean platelet volume; BRCA trans rs3733585 0.673 rs7378340 chr4:9955198 C/T cg26043149 chr18:55253948 FECH -0.37 -8.23 -0.31 1.09e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg00504896 chr12:9437009 LOC642846 -0.46 -10.17 -0.37 1.25e-22 Breast size; BRCA cis rs881375 1.000 rs4323544 chr9:123647377 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.05 0.4 4.16e-26 Rheumatoid arthritis; BRCA cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg06064525 chr11:970664 AP2A2 -0.48 -16.24 -0.54 6.84e-50 Alzheimer's disease (late onset); BRCA cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg08847533 chr14:75593920 NEK9 0.83 20.57 0.63 1.56e-72 Height; BRCA cis rs17384381 0.859 rs12130591 chr1:85904985 C/T cg16011679 chr1:85725395 C1orf52 0.51 7.98 0.3 6.81e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs877282 1.000 rs112522746 chr10:772288 T/C cg17470449 chr10:769945 NA 0.5 9.35 0.35 1.44e-19 Uric acid levels; BRCA trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg15704280 chr7:45808275 SEPT13 -0.48 -9.84 -0.36 2.28e-21 HDL cholesterol; BRCA trans rs7746199 0.673 rs35501037 chr6:27739566 T/A cg06606381 chr12:133084897 FBRSL1 -0.85 -8.79 -0.33 1.33e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs11098499 0.754 rs10212775 chr4:120239244 G/C cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA cis rs8030485 0.728 rs4778886 chr15:79389019 T/C cg17916960 chr15:79447300 NA 0.34 7.85 0.3 1.72e-14 Left ventricle wall thickness; BRCA cis rs694739 0.595 rs11542299 chr11:64138805 T/C cg26898376 chr11:64110657 CCDC88B 0.36 7.86 0.3 1.62e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs7264396 0.790 rs1040695 chr20:34244829 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.89 -0.53 3.7e-48 Total cholesterol levels; BRCA cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg15485101 chr11:133734466 NA 0.41 9.66 0.36 1.11e-20 Childhood ear infection; BRCA trans rs11098499 0.644 rs7693919 chr4:120540571 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.11 0.37 2.1e-22 Corneal astigmatism; BRCA cis rs11779988 0.545 rs398806 chr8:17786226 T/C cg01800426 chr8:17659068 MTUS1 -0.4 -8.41 -0.32 2.65e-16 Breast cancer; BRCA trans rs3960554 0.569 rs1894761 chr7:75876754 C/T cg19862616 chr7:65841803 NCRNA00174 -0.48 -11.02 -0.4 5.44e-26 Eotaxin levels; BRCA cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg12923728 chr3:195709715 SDHAP1 -0.59 -12.56 -0.45 1.67e-32 Pancreatic cancer; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00908189 chr16:619842 PIGQ 0.68 16.82 0.55 8.26e-53 Height; BRCA cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg16489826 chr6:160211363 TCP1;MRPL18 0.62 13.02 0.46 1.48e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -9.48 -0.35 4.72e-20 Response to bleomycin (chromatid breaks); BRCA cis rs12291225 0.679 rs4757245 chr11:14297872 A/C cg19336497 chr11:14380999 RRAS2 -0.48 -11.99 -0.43 4.92e-30 Sense of smell; BRCA cis rs523522 0.962 rs3759394 chr12:120933173 C/A cg12219531 chr12:120966889 COQ5 0.55 11.42 0.41 1.25e-27 High light scatter reticulocyte count; BRCA cis rs35306767 0.903 rs765867 chr10:869901 G/T cg25019033 chr10:957182 NA -0.42 -8.07 -0.3 3.47e-15 Eosinophil percentage of granulocytes; BRCA cis rs2204008 0.652 rs11520002 chr12:38022179 G/T cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.62e-22 Bladder cancer; BRCA trans rs28735056 0.592 rs10853392 chr18:77708781 A/G cg05926928 chr17:57297772 GDPD1 -0.42 -8.65 -0.32 4.02e-17 Schizophrenia; BRCA cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 4.03e-25 Bipolar disorder; BRCA cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.34 -0.41 2.88e-27 Electroencephalogram traits; BRCA cis rs7618915 0.547 rs11177 chr3:52721305 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.66 0.36 1.07e-20 Bipolar disorder; BRCA cis rs875971 0.964 rs6978721 chr7:65883204 A/G cg18876405 chr7:65276391 NA 0.56 13.33 0.47 6.11e-36 Aortic root size; BRCA cis rs11711311 1.000 rs7622515 chr3:113472538 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.34 0.35 1.58e-19 IgG glycosylation; BRCA cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg10556349 chr10:835070 NA 0.61 8.43 0.32 2.32e-16 Eosinophil percentage of granulocytes; BRCA cis rs2204008 0.641 rs66876045 chr12:38205713 G/A cg26384229 chr12:38710491 ALG10B 0.7 15.83 0.53 7.18e-48 Bladder cancer; BRCA cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.18e-17 Glomerular filtration rate (creatinine); BRCA cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg18016565 chr1:150552671 MCL1 0.36 8.55 0.32 9.09e-17 Tonsillectomy; BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg04166393 chr7:2884313 GNA12 0.46 8.54 0.32 9.8e-17 Height; BRCA cis rs2797160 1.000 rs1739363 chr6:126020980 G/A cg05901451 chr6:126070800 HEY2 0.39 9.51 0.35 3.87e-20 Endometrial cancer; BRCA cis rs6964587 1.000 rs10235941 chr7:91587050 T/G cg01689657 chr7:91764605 CYP51A1 0.21 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs3784262 0.669 rs4646602 chr15:58294757 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.04 -0.37 4.14e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.04 0.58 4e-59 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2204008 0.774 rs3910796 chr12:38230660 G/T cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg02659138 chr7:134003124 SLC35B4 0.37 10.87 0.4 2.21e-25 Mean platelet volume; BRCA cis rs7246657 0.943 rs2081096 chr19:37964700 G/A cg23950597 chr19:37808831 NA -0.61 -11.4 -0.41 1.5e-27 Coronary artery calcification; BRCA cis rs6952809 0.590 rs1468337 chr7:2432211 C/T cg23289794 chr7:2394357 EIF3B -0.53 -10.45 -0.38 1.05e-23 Multiple sclerosis; BRCA cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg00631329 chr6:26305371 NA -0.43 -12.72 -0.45 3.24e-33 Educational attainment; BRCA cis rs514406 0.929 rs557715 chr1:53321593 C/G cg27535305 chr1:53392650 SCP2 -0.37 -9.27 -0.34 2.78e-19 Monocyte count; BRCA cis rs17095355 1.000 rs12254785 chr10:111699607 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.26 -0.38 5.76e-23 Biliary atresia; BRCA cis rs7267979 1.000 rs4815426 chr20:25405186 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.2 -0.34 5.21e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9487051 0.872 rs9487043 chr6:109610474 C/T cg21918786 chr6:109611834 NA -0.5 -14.01 -0.48 4.55e-39 Reticulocyte fraction of red cells; BRCA cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.16 0.37 1.4e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg01475377 chr6:109611718 NA -0.51 -12.88 -0.45 6.46e-34 Reticulocyte fraction of red cells; BRCA cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg08999081 chr20:33150536 PIGU -0.48 -13.41 -0.47 2.64e-36 Glomerular filtration rate (creatinine); BRCA cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg08213375 chr14:104286397 PPP1R13B 0.63 17.42 0.57 6.31e-56 Schizophrenia; BRCA cis rs7927592 0.913 rs10896329 chr11:68250029 A/G cg20283391 chr11:68216788 NA -0.49 -9.52 -0.35 3.55e-20 Total body bone mineral density; BRCA cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg15997130 chr1:24165203 NA 0.46 11.75 0.42 5.29e-29 Immature fraction of reticulocytes; BRCA cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg02297831 chr4:17616191 MED28 0.38 8.52 0.32 1.12e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17270561 0.609 rs3778272 chr6:25767661 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA trans rs61931739 0.500 rs12829125 chr12:34314789 A/G cg26384229 chr12:38710491 ALG10B 0.67 14.21 0.49 5.23e-40 Morning vs. evening chronotype; BRCA cis rs2882667 0.858 rs13174479 chr5:138444170 G/A cg04439458 chr5:138467593 SIL1 -0.41 -10.51 -0.38 6.31e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs72634258 0.786 rs7524424 chr1:8173369 A/G cg00042356 chr1:8021962 PARK7 0.46 8.27 0.31 7.83e-16 Inflammatory bowel disease; BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg27170947 chr2:26402098 FAM59B 0.98 17.0 0.56 8.96e-54 Gut microbiome composition (summer); BRCA cis rs9311474 0.569 rs7614981 chr3:52566914 G/T cg17372223 chr3:52568218 NT5DC2 0.36 8.61 0.32 5.58e-17 Electroencephalogram traits; BRCA cis rs36051895 0.603 rs1590804 chr9:5177573 T/C cg02405213 chr9:5042618 JAK2 -0.47 -9.06 -0.34 1.52e-18 Pediatric autoimmune diseases; BRCA cis rs1707322 0.890 rs2297883 chr1:46511487 G/C cg06784218 chr1:46089804 CCDC17 -0.45 -10.84 -0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7824557 0.836 rs765731 chr8:11121498 T/A cg06636001 chr8:8085503 FLJ10661 -0.56 -10.73 -0.39 8.05e-25 Retinal vascular caliber; BRCA cis rs4268898 0.722 rs12185638 chr2:24382030 C/G cg06627628 chr2:24431161 ITSN2 0.44 9.11 0.34 1.07e-18 Asthma; BRCA cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 11.99 0.43 5.33e-30 Mean platelet volume; BRCA trans rs3857536 0.813 rs6455090 chr6:66948909 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.82 -0.3 2.17e-14 Blood trace element (Cu levels); BRCA cis rs1538970 0.816 rs868351 chr1:46009818 G/T cg05343316 chr1:45956843 TESK2 0.7 13.86 0.48 2.25e-38 Platelet count; BRCA cis rs59918340 0.728 rs4961340 chr8:142232002 G/A cg23750338 chr8:142222470 SLC45A4 0.51 12.52 0.44 2.45e-32 Immature fraction of reticulocytes; BRCA cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg09184832 chr6:79620586 NA -0.43 -8.45 -0.32 2.03e-16 Intelligence (multi-trait analysis); BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg12444411 chr7:2802554 GNA12 -0.32 -8.34 -0.31 4.74e-16 Height; BRCA cis rs9790314 0.715 rs898681 chr3:160773098 A/G cg03342759 chr3:160939853 NMD3 -0.52 -10.04 -0.37 3.9e-22 Morning vs. evening chronotype; BRCA cis rs4930561 0.677 rs7946212 chr11:67982187 T/A cg04465784 chr11:67976953 SUV420H1 -0.27 -8.56 -0.32 8.27e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs9287719 0.578 rs10168852 chr2:10746323 C/A cg00105475 chr2:10696890 NA 0.48 10.55 0.39 4.24e-24 Prostate cancer; BRCA cis rs3768617 0.510 rs10797838 chr1:183077020 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 18.95 0.6 7.1e-64 Fuchs's corneal dystrophy; BRCA cis rs2276314 0.857 rs62101376 chr18:33582955 T/C cg05985134 chr18:33552581 C18orf21 0.61 10.84 0.39 2.87e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 10.71 0.39 1.02e-24 Bipolar disorder; BRCA cis rs9790314 0.934 rs9290074 chr3:160997823 T/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.13 -0.49 1.19e-39 Morning vs. evening chronotype; BRCA cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg01849466 chr14:104193079 ZFYVE21 -0.42 -10.5 -0.38 6.96e-24 Schizophrenia; BRCA cis rs62229266 0.804 rs11088331 chr21:37421872 T/C cg12218747 chr21:37451666 NA -0.33 -7.94 -0.3 9.32e-15 Mitral valve prolapse; BRCA cis rs7552404 0.924 rs1313071 chr1:76195542 C/G cg22875332 chr1:76189707 ACADM 0.66 15.7 0.53 3.07e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs897080 0.553 rs1067338 chr2:44624708 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.54 10.32 0.38 3.38e-23 Height; BRCA cis rs911119 0.955 rs6036474 chr20:23604414 G/A cg16589663 chr20:23618590 CST3 0.43 8.19 0.31 1.42e-15 Chronic kidney disease; BRCA cis rs861020 1.000 rs642961 chr1:209989270 A/G cg05527609 chr1:210001259 C1orf107 0.74 17.08 0.56 3.49e-54 Orofacial clefts; BRCA cis rs4268898 0.662 rs74470633 chr2:24438712 A/G cg06627628 chr2:24431161 ITSN2 -0.84 -15.51 -0.52 2.91e-46 Asthma; BRCA cis rs6433895 1.000 rs34714467 chr2:182017987 G/A cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs701145 0.640 rs357497 chr3:153943068 C/A cg17054900 chr3:154042577 DHX36 0.58 9.73 0.36 5.84e-21 Coronary artery disease; BRCA trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.74 0.36 5.38e-21 Morning vs. evening chronotype; BRCA cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24531977 chr5:56204891 C5orf35 -0.86 -18.37 -0.59 7.75e-61 Initial pursuit acceleration; BRCA cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg06627628 chr2:24431161 ITSN2 -0.55 -9.0 -0.34 2.59e-18 Lymphocyte counts; BRCA cis rs11190604 1.000 rs7084810 chr10:102297546 A/G cg07080220 chr10:102295463 HIF1AN 0.62 14.64 0.5 4.63e-42 Palmitoleic acid (16:1n-7) levels; BRCA cis rs3008870 1.000 rs3008888 chr1:67368965 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.95 21.05 0.64 4.24e-75 Lymphocyte percentage of white cells; BRCA cis rs6430585 0.697 rs7607174 chr2:136513670 T/A cg07169764 chr2:136633963 MCM6 1.23 26.19 0.72 2.99e-103 Corneal structure; BRCA cis rs10883723 0.962 rs10883726 chr10:104236276 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.6 17.47 0.57 3.6e-56 Allergic disease (asthma, hay fever or eczema); BRCA trans rs6598955 0.671 rs17257169 chr1:26570009 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -13.02 -0.46 1.59e-34 Obesity-related traits; BRCA cis rs10189230 0.967 rs11692482 chr2:222352405 C/T cg14652038 chr2:222343519 EPHA4 0.47 13.11 0.46 6.05e-35 Urate levels in lean individuals; BRCA cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg25405998 chr7:65216604 CCT6P1 -0.42 -8.85 -0.33 8.36e-18 Calcium levels; BRCA cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg08048268 chr3:133502702 NA 0.32 8.33 0.31 4.77e-16 Iron status biomarkers; BRCA cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg13256891 chr4:100009986 ADH5 0.5 10.35 0.38 2.51e-23 Alcohol dependence; BRCA cis rs877282 1.000 rs7100358 chr10:773681 G/A cg17470449 chr10:769945 NA 0.49 9.36 0.35 1.37e-19 Uric acid levels; BRCA trans rs8062405 1.000 rs4788095 chr16:28831359 T/C cg09719594 chr16:21412588 NA -0.32 -7.82 -0.3 2.19e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7666738 1.000 rs13144055 chr4:99026849 A/G cg03676636 chr4:99064102 C4orf37 0.24 8.18 0.31 1.53e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6709815 0.841 rs12694442 chr2:219663599 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -10.18 -0.37 1.18e-22 Reticulocyte count;High light scatter reticulocyte count; BRCA cis rs11608355 0.545 rs12819658 chr12:109907670 A/T cg05360138 chr12:110035743 NA 0.71 13.15 0.46 4.04e-35 Neuroticism; BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs4642101 0.535 rs55692304 chr3:12840057 C/T cg24848339 chr3:12840334 CAND2 0.52 14.13 0.49 1.18e-39 QRS complex (12-leadsum); BRCA cis rs858239 0.799 rs10279941 chr7:23370508 C/G cg23682824 chr7:23144976 KLHL7 0.33 8.17 0.31 1.62e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg12923728 chr3:195709715 SDHAP1 -0.53 -7.94 -0.3 9.15e-15 Lung disease severity in cystic fibrosis; BRCA trans rs1941687 0.505 rs12605642 chr18:31313965 G/T cg27147174 chr7:100797783 AP1S1 -0.4 -7.89 -0.3 1.36e-14 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs2197308 0.605 rs2387437 chr12:37919367 T/C cg06521331 chr12:34319734 NA -0.54 -10.29 -0.38 4.42e-23 Morning vs. evening chronotype; BRCA cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1400816 0.702 rs1515812 chr2:172558047 G/A cg13550731 chr2:172543902 DYNC1I2 0.54 8.48 0.32 1.56e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.14e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2710642 0.962 rs4671051 chr2:63032696 A/T cg17519650 chr2:63277830 OTX1 -0.39 -8.58 -0.32 7.06e-17 LDL cholesterol levels;LDL cholesterol; BRCA cis rs4974559 0.947 rs28540746 chr4:1352954 G/A cg02980000 chr4:1222292 CTBP1 0.76 12.75 0.45 2.41e-33 Systolic blood pressure; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00802000 chr16:706648 WDR90 -0.41 -9.55 -0.35 2.61e-20 Height; BRCA cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.29 -0.38 4.51e-23 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg11822812 chr5:140052017 DND1 0.29 8.01 0.3 5.26e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg08048268 chr3:133502702 NA -0.32 -8.14 -0.31 2.12e-15 Iron status biomarkers; BRCA cis rs6088590 1.000 rs2295354 chr20:33356541 T/C cg24642439 chr20:33292090 TP53INP2 0.72 16.61 0.55 8.91e-52 Coronary artery disease; BRCA cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg07636037 chr3:49044803 WDR6 0.97 28.37 0.75 3.38e-115 Parkinson's disease; BRCA cis rs11608355 0.515 rs7971160 chr12:109946751 T/A cg05360138 chr12:110035743 NA 0.74 13.64 0.47 2.36e-37 Neuroticism; BRCA cis rs9300255 0.722 rs1060105 chr12:123806219 C/T cg00376283 chr12:123451042 ABCB9 -0.52 -10.32 -0.38 3.45e-23 Neutrophil percentage of white cells; BRCA cis rs35110281 0.748 rs4997353 chr21:45002329 A/C cg04455712 chr21:45112962 RRP1B 0.41 10.73 0.39 8.24e-25 Mean corpuscular volume; BRCA cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10872587 0.657 rs11155459 chr6:146578751 A/G cg13319975 chr6:146136371 FBXO30 0.42 8.46 0.32 1.86e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.808 rs9361484 chr6:79758218 C/A cg18132916 chr6:79620363 NA -0.49 -11.14 -0.4 1.87e-26 Intelligence (multi-trait analysis); BRCA cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg08999081 chr20:33150536 PIGU 0.35 8.78 0.33 1.48e-17 Coronary artery disease; BRCA cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg26031613 chr14:104095156 KLC1 -0.53 -9.49 -0.35 4.66e-20 Reticulocyte count; BRCA cis rs6598955 0.671 rs10493030 chr1:26561856 T/C cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg10729496 chr3:10149963 C3orf24 0.48 9.11 0.34 1.02e-18 Alzheimer's disease; BRCA cis rs7474896 0.559 rs1208560 chr10:38221618 A/T cg25427524 chr10:38739819 LOC399744 0.52 9.66 0.36 1.05e-20 Obesity (extreme); BRCA cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg05347473 chr6:146136440 FBXO30 0.42 8.45 0.32 2.03e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs738321 0.757 rs5750546 chr22:38542499 C/T cg25457927 chr22:38595422 NA -0.36 -12.62 -0.45 9.02e-33 Breast cancer; BRCA cis rs7715806 0.500 rs17649350 chr5:75006156 C/T cg19683494 chr5:74908142 NA -0.53 -8.73 -0.33 2.22e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg02951883 chr7:2050386 MAD1L1 -0.49 -11.46 -0.41 8.97e-28 Bipolar disorder and schizophrenia; BRCA cis rs68170813 0.523 rs111590023 chr7:107055323 T/C cg02696742 chr7:106810147 HBP1 -0.46 -8.03 -0.3 4.77e-15 Coronary artery disease; BRCA cis rs6866344 0.697 rs17184302 chr5:178127676 C/T cg10224037 chr5:178157518 ZNF354A 0.76 15.87 0.53 4.64e-48 Neutrophil percentage of white cells; BRCA cis rs6028335 0.674 rs3829696 chr20:37634704 C/T cg16355469 chr20:37678765 NA -0.44 -8.16 -0.31 1.78e-15 Alcohol and nicotine co-dependence; BRCA cis rs8180040 0.726 rs2305634 chr3:47043538 A/G cg02527881 chr3:46936655 PTH1R 0.36 8.66 0.32 3.73e-17 Colorectal cancer; BRCA cis rs7659604 0.539 rs11098648 chr4:122759872 C/T cg20573242 chr4:122745356 CCNA2 0.49 10.94 0.4 1.23e-25 Type 2 diabetes; BRCA cis rs9649465 1.000 rs10215466 chr7:123326044 G/T cg04330084 chr7:123175371 IQUB -0.3 -8.38 -0.31 3.26e-16 Migraine; BRCA cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg26031613 chr14:104095156 KLC1 0.55 9.86 0.36 1.88e-21 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs2637030 0.559 rs372135 chr5:52944948 T/C cg06476337 chr5:52856530 NDUFS4 0.37 8.5 0.32 1.36e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs4690686 0.500 rs11728314 chr4:177268373 G/A cg17059388 chr4:177262070 NA 0.51 10.65 0.39 1.7e-24 Essential tremor; BRCA cis rs2235642 0.893 rs2076440 chr16:1587322 G/A cg26528668 chr16:1614120 IFT140 0.38 8.45 0.32 1.99e-16 Coronary artery disease; BRCA cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg06784218 chr1:46089804 CCDC17 0.49 11.55 0.42 3.77e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs636291 0.517 rs11121579 chr1:10541824 G/C cg17425144 chr1:10567563 PEX14 0.55 13.76 0.48 6.67e-38 Prostate cancer; BRCA cis rs9486719 1.000 rs9486719 chr6:97060124 G/A cg06623918 chr6:96969491 KIAA0776 -0.78 -15.88 -0.53 4.21e-48 Migraine;Coronary artery disease; BRCA cis rs1953600 0.837 rs3098105 chr10:81953266 C/T cg04850286 chr10:81895943 PLAC9 0.32 9.0 0.34 2.57e-18 Sarcoidosis; BRCA cis rs910316 1.000 rs175425 chr14:75626131 T/C cg11812906 chr14:75593930 NEK9 -0.63 -14.3 -0.49 1.84e-40 Height; BRCA cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.61e-24 Motion sickness; BRCA cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg12011299 chr4:100065546 ADH4 -0.5 -11.33 -0.41 3.03e-27 Alcohol dependence; BRCA cis rs867371 0.820 rs12443224 chr15:82495610 C/T cg00614314 chr15:82944287 LOC80154 0.38 7.96 0.3 7.71e-15 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg04234412 chr22:24373322 LOC391322 0.57 12.35 0.44 1.37e-31 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs6426558 0.537 rs1320494 chr1:227241300 A/T cg10327440 chr1:227177885 CDC42BPA 0.49 9.75 0.36 5.15e-21 Neutrophil percentage of white cells; BRCA cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.951 rs281793 chr2:200847990 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.3 0.47 8.12e-36 Schizophrenia; BRCA cis rs61931739 0.534 rs11053049 chr12:34164537 T/C cg06521331 chr12:34319734 NA -0.63 -11.49 -0.41 6.35e-28 Morning vs. evening chronotype; BRCA cis rs853679 0.517 rs9393896 chr6:28127703 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs9790314 0.747 rs1841526 chr3:160834682 A/G cg04691961 chr3:161091175 C3orf57 -0.46 -9.88 -0.36 1.65e-21 Morning vs. evening chronotype; BRCA cis rs4566357 0.595 rs6707159 chr2:227909339 T/A cg11843606 chr2:227700838 RHBDD1 -0.43 -9.65 -0.36 1.13e-20 Coronary artery disease; BRCA cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg23711669 chr6:146136114 FBXO30 -0.79 -18.94 -0.6 8.14e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs67460515 0.892 rs34771618 chr3:161059795 A/C cg03342759 chr3:160939853 NMD3 -0.81 -19.09 -0.6 1.33e-64 Parkinson's disease; BRCA cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.66e-15 Menopause (age at onset); BRCA cis rs7666738 0.830 rs4699580 chr4:98930673 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg11663144 chr21:46675770 NA -0.61 -14.24 -0.49 3.81e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2839186 0.934 rs2839197 chr21:47708133 A/G cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs8177253 0.965 rs7638018 chr3:133495461 C/T cg12373951 chr3:133503437 NA -0.44 -10.57 -0.39 3.54e-24 Iron status biomarkers; BRCA cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg13114125 chr14:105738426 BRF1 -0.5 -10.4 -0.38 1.64e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg21770322 chr7:97807741 LMTK2 0.5 14.15 0.49 9.55e-40 Breast cancer; BRCA cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -9.43 -0.35 7.23e-20 Response to bleomycin (chromatid breaks); BRCA cis rs9649465 0.967 rs12534834 chr7:123307079 T/C cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.53e-16 Migraine; BRCA cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg23711669 chr6:146136114 FBXO30 -0.81 -19.89 -0.62 6.69e-69 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg17971929 chr21:40555470 PSMG1 -0.63 -14.39 -0.49 7.3e-41 Cognitive function; BRCA cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg12011299 chr4:100065546 ADH4 0.48 10.94 0.4 1.21e-25 Smoking initiation; BRCA cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg08514558 chr10:81106712 PPIF 0.37 8.99 0.34 2.78e-18 Height; BRCA cis rs16910800 0.731 rs16910759 chr11:23192131 C/G cg20040320 chr11:23191996 NA -0.58 -10.0 -0.37 5.63e-22 Cancer; BRCA cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.754 rs6922507 chr6:146250155 A/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.9 -0.3 1.2e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg26031613 chr14:104095156 KLC1 -0.44 -8.72 -0.33 2.36e-17 Schizophrenia; BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.37e-15 Total body bone mineral density; BRCA cis rs36051895 0.632 rs7850484 chr9:5147817 C/T cg02405213 chr9:5042618 JAK2 -0.5 -9.6 -0.36 1.72e-20 Pediatric autoimmune diseases; BRCA cis rs796364 0.625 rs4673837 chr2:201131159 A/G cg23649088 chr2:200775458 C2orf69 0.47 8.06 0.3 3.74e-15 Schizophrenia; BRCA cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -10.59 -0.39 2.95e-24 Bipolar disorder; BRCA cis rs7412746 0.611 rs3768018 chr1:150723747 T/C cg15448220 chr1:150897856 SETDB1 0.37 8.32 0.31 5.23e-16 Melanoma; BRCA cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.71 0.39 1.02e-24 Bipolar disorder; BRCA cis rs9527 0.637 rs12219247 chr10:104613361 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.46 0.38 9.81e-24 Arsenic metabolism; BRCA trans rs10411161 0.702 rs11878586 chr19:52388576 A/G cg22319618 chr22:45562946 NUP50 -0.42 -8.02 -0.3 4.89e-15 Breast cancer; BRCA cis rs1059312 0.932 rs4760593 chr12:129287220 A/G cg09035930 chr12:129282057 SLC15A4 0.57 16.85 0.55 5.49e-53 Systemic lupus erythematosus; BRCA cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg16339924 chr4:17578868 LAP3 0.74 18.77 0.6 6.15e-63 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12188164 0.525 rs1114665 chr5:452247 C/T cg26850624 chr5:429559 AHRR 0.34 7.96 0.3 7.62e-15 Cystic fibrosis severity; BRCA cis rs3733346 0.553 rs2290403 chr4:942006 G/A cg08222618 chr4:941054 TMEM175 0.41 9.43 0.35 7.27e-20 Sjögren's syndrome; BRCA cis rs7520050 0.966 rs785503 chr1:46595868 T/C cg24296786 chr1:45957014 TESK2 0.41 9.12 0.34 1e-18 Red blood cell count;Reticulocyte count; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg18758796 chr5:131593413 PDLIM4 0.43 11.3 0.41 3.86e-27 Acylcarnitine levels; BRCA cis rs4423214 0.879 rs1792277 chr11:71138918 C/T cg05163923 chr11:71159392 DHCR7 -0.55 -11.06 -0.4 3.76e-26 Vitamin D levels; BRCA trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg03929089 chr4:120376271 NA 0.65 12.72 0.45 3.44e-33 Coronary artery disease; BRCA cis rs6542838 0.611 rs7423519 chr2:99518319 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.38 -8.44 -0.32 2.06e-16 Fear of minor pain; BRCA cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg15412446 chr2:106886593 NA 0.6 12.12 0.43 1.4e-30 Facial morphology (factor 23); BRCA cis rs12472274 0.941 rs12616232 chr2:239080093 C/T cg17459225 chr2:239074497 NA 0.62 12.59 0.45 1.27e-32 Phospholipid levels (plasma); BRCA trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg03929089 chr4:120376271 NA -0.43 -8.07 -0.3 3.6e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg24088639 chr11:34937564 PDHX;APIP -0.4 -9.03 -0.34 2.08e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6964587 1.000 rs10488510 chr7:91660225 G/T cg17063962 chr7:91808500 NA 0.57 13.6 0.47 3.52e-37 Breast cancer; BRCA cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg05234568 chr11:5960015 NA -0.43 -8.89 -0.33 6.25e-18 DNA methylation (variation); BRCA cis rs5771069 0.931 rs5771222 chr22:50445704 C/T cg03721641 chr22:50451245 IL17REL -0.31 -9.88 -0.36 1.58e-21 Ulcerative colitis; BRCA cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg11608241 chr8:8085544 FLJ10661 0.32 7.91 0.3 1.17e-14 Red cell distribution width; BRCA trans rs7200543 1.000 rs34614532 chr16:15132908 T/C cg24683922 chr1:11983373 KIAA2013 -0.39 -8.72 -0.33 2.32e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg04518342 chr5:131593106 PDLIM4 0.37 9.47 0.35 5.4e-20 Breast cancer; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg18402987 chr7:1209562 NA 0.66 11.21 0.41 9.4e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6089584 0.566 rs6061401 chr20:60607482 G/A cg06108461 chr20:60628389 TAF4 -0.71 -14.74 -0.5 1.52e-42 Body mass index; BRCA cis rs870825 0.929 rs72689255 chr4:185590141 T/C cg20176042 chr4:185552304 CASP3 -0.62 -8.51 -0.32 1.27e-16 Blood protein levels; BRCA cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.49 9.41 0.35 8.83e-20 Lung cancer in ever smokers; BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg24082983 chr21:31802169 KRTAP13-4 0.35 8.65 0.32 4.12e-17 HDL cholesterol; BRCA cis rs1580019 0.961 rs6949851 chr7:32493807 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.38 8.18 0.31 1.49e-15 Cognitive ability; BRCA cis rs4900538 0.819 rs72698595 chr14:102863099 G/A cg18135206 chr14:102964638 TECPR2 -0.9 -20.78 -0.63 1.22e-73 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7945718 0.967 rs10765989 chr11:12769397 A/G cg25843174 chr11:12811716 TEAD1 -0.22 -8.69 -0.33 3e-17 Educational attainment (years of education); BRCA cis rs1832871 0.619 rs262826 chr6:158680567 C/T cg07215822 chr6:158701037 NA -0.5 -10.53 -0.38 4.88e-24 Height; BRCA cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg08280861 chr8:58055591 NA 0.53 8.49 0.32 1.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.545 rs4718325 chr7:65680310 G/A cg11764359 chr7:65958608 NA 0.63 10.91 0.4 1.5e-25 Aortic root size; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.12 0.58 1.61e-59 Alzheimer's disease; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs2011503 0.883 rs17216041 chr19:19366643 C/T cg11584989 chr19:19387371 SF4 0.63 13.76 0.48 6.11e-38 Bipolar disorder; BRCA cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg24549020 chr5:56110836 MAP3K1 0.67 13.55 0.47 6.19e-37 Initial pursuit acceleration; BRCA cis rs6500602 0.627 rs9938228 chr16:4530597 T/C cg08645402 chr16:4508243 NA 0.4 9.17 0.34 6.25e-19 Schizophrenia; BRCA cis rs1883415 0.534 rs2760145 chr6:24478813 T/C cg20631270 chr6:24437470 GPLD1 0.4 8.16 0.31 1.78e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.715 rs61114099 chr4:98931270 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4660306 1.000 rs10157597 chr1:45990278 C/A cg24296786 chr1:45957014 TESK2 0.43 8.6 0.32 5.99e-17 Homocysteine levels; BRCA trans rs11039798 0.541 rs12283728 chr11:48796407 G/A cg15704280 chr7:45808275 SEPT13 0.59 8.84 0.33 9.53e-18 Axial length; BRCA cis rs6691722 0.503 rs1142057 chr1:24706292 C/T cg18323236 chr1:24743029 NIPAL3 -0.29 -7.92 -0.3 1.06e-14 Response to interferon beta in multiple sclerosis; BRCA cis rs67478160 0.529 rs12880413 chr14:104267407 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.29e-16 Schizophrenia; BRCA cis rs875971 0.964 rs6978429 chr7:65959876 T/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.96 -0.33 3.49e-18 Monocyte percentage of white cells; BRCA cis rs7587476 0.784 rs62202001 chr2:215690359 C/G cg04004882 chr2:215674386 BARD1 0.67 12.38 0.44 1.05e-31 Neuroblastoma; BRCA cis rs2882667 0.654 rs6863054 chr5:138188855 C/T cg04439458 chr5:138467593 SIL1 0.31 7.94 0.3 8.82e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7044106 0.762 rs7357638 chr9:123389204 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 13.82 0.48 3.55e-38 Hip circumference adjusted for BMI; BRCA cis rs709400 0.520 rs28583452 chr14:103938664 C/A cg26031613 chr14:104095156 KLC1 0.74 16.27 0.54 4.7e-50 Body mass index; BRCA cis rs6121246 0.609 rs6088997 chr20:30289824 A/G cg13852791 chr20:30311386 BCL2L1 -0.83 -17.72 -0.57 1.86e-57 Mean corpuscular hemoglobin; BRCA cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg20933634 chr6:27740509 NA 0.45 9.0 0.34 2.5e-18 Parkinson's disease; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg04013093 chr6:42928303 GNMT -0.29 -8.93 -0.33 4.33e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs739401 0.527 rs423236 chr11:3065916 C/T cg05729581 chr11:3078854 CARS -0.34 -8.46 -0.32 1.76e-16 Longevity; BRCA cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg06784218 chr1:46089804 CCDC17 -0.5 -11.63 -0.42 1.74e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9394152 0.845 rs7747216 chr6:33476718 A/G cg13560919 chr6:33536144 NA -0.62 -12.95 -0.46 3.09e-34 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9381107 0.932 rs16892227 chr6:9425046 A/G cg14735645 chr6:9486422 NA -0.47 -8.18 -0.31 1.52e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg21132104 chr15:45694354 SPATA5L1 0.74 16.96 0.56 1.57e-53 Homoarginine levels; BRCA cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.5 9.65 0.36 1.21e-20 Lung cancer in ever smokers; BRCA cis rs2153535 0.580 rs5001130 chr6:8442298 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.24e-41 Motion sickness; BRCA cis rs11971779 0.680 rs10271297 chr7:139052310 A/T cg07862535 chr7:139043722 LUC7L2 0.37 10.08 0.37 2.71e-22 Diisocyanate-induced asthma; BRCA cis rs1707322 0.752 rs3811435 chr1:46125790 C/A cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs60843830 1.000 rs62114501 chr2:231741 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 14.64 0.5 4.38e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg18279126 chr7:2041391 MAD1L1 0.38 8.51 0.32 1.21e-16 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.820 rs28535956 chr4:120536858 C/T cg09307838 chr4:120376055 NA -0.69 -13.6 -0.47 3.66e-37 Corneal astigmatism; BRCA cis rs12545109 0.879 rs2609994 chr8:57365844 A/G cg09654669 chr8:57350985 NA -0.46 -8.66 -0.32 3.82e-17 Obesity-related traits; BRCA trans rs6600671 0.966 rs6600664 chr1:121222436 G/A cg17023122 chr1:144479586 NA 0.35 8.04 0.3 4.29e-15 Hip geometry; BRCA cis rs7666738 0.791 rs62318907 chr4:99037120 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.61e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9986765 1.000 rs73452570 chr7:142817482 T/A cg21852589 chr7:142981689 TMEM139 0.55 9.52 0.35 3.4e-20 Cancer;Dermatomyositis; BRCA cis rs17253792 0.822 rs75936910 chr14:56149351 T/C cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg13271783 chr10:134563150 INPP5A -0.5 -9.26 -0.34 3.01e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg12386194 chr3:101231763 SENP7 0.45 9.37 0.35 1.18e-19 Colorectal cancer; BRCA cis rs7666738 0.546 rs10026181 chr4:98814118 C/T cg05340658 chr4:99064831 C4orf37 -0.55 -10.48 -0.38 8.06e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 0.709 rs11072597 chr15:76763514 C/A cg23625390 chr15:77176239 SCAPER -0.51 -11.94 -0.43 8.44e-30 Blood metabolite levels; BRCA cis rs6542838 0.582 rs6542845 chr2:99537600 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -9.69 -0.36 8.2e-21 Fear of minor pain; BRCA cis rs12493885 0.818 rs73158491 chr3:153764112 T/C cg17054900 chr3:154042577 DHX36 -0.5 -8.54 -0.32 9.6e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs910316 0.934 rs7141705 chr14:75655352 G/C cg11812906 chr14:75593930 NEK9 -0.62 -14.25 -0.49 3.28e-40 Height; BRCA cis rs2075371 0.674 rs11771785 chr7:134013249 A/G cg20476274 chr7:133979776 SLC35B4 -0.48 -11.0 -0.4 7.04e-26 Mean platelet volume; BRCA cis rs7659604 0.628 rs6838153 chr4:122720999 A/G cg20573242 chr4:122745356 CCNA2 0.49 10.79 0.39 4.65e-25 Type 2 diabetes; BRCA cis rs911119 0.955 rs6114201 chr20:23607231 T/A cg16589663 chr20:23618590 CST3 0.4 8.2 0.31 1.34e-15 Chronic kidney disease; BRCA cis rs6460942 0.915 rs1595800 chr7:12439816 G/A cg06484146 chr7:12443880 VWDE -0.71 -10.81 -0.39 4.05e-25 Coronary artery disease; BRCA cis rs7520050 0.966 rs10789475 chr1:46304177 C/G cg24296786 chr1:45957014 TESK2 0.41 9.34 0.35 1.53e-19 Red blood cell count;Reticulocyte count; BRCA cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.03 -0.34 1.97e-18 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.519 rs13136069 chr4:98819568 C/T cg05340658 chr4:99064831 C4orf37 0.56 10.76 0.39 6.41e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.0 -0.34 2.52e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs7493 0.853 rs2299266 chr7:95049073 A/G cg19678392 chr7:94953810 PON1 -0.41 -8.51 -0.32 1.27e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg16606324 chr3:10149918 C3orf24 0.56 11.01 0.4 5.91e-26 Alzheimer's disease; BRCA cis rs6547741 1.000 rs4666007 chr2:27856495 T/C cg27432699 chr2:27873401 GPN1 0.43 9.19 0.34 5.65e-19 Oral cavity cancer; BRCA cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg03388025 chr16:89894329 SPIRE2 -0.29 -9.66 -0.36 1.03e-20 Vitiligo; BRCA trans rs7824557 0.628 rs7841394 chr8:11185671 G/T cg06636001 chr8:8085503 FLJ10661 0.41 8.22 0.31 1.17e-15 Retinal vascular caliber; BRCA cis rs13256369 1.000 rs12547721 chr8:8570671 C/T cg18904891 chr8:8559673 CLDN23 0.61 12.07 0.43 2.35e-30 Obesity-related traits; BRCA cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg15017067 chr4:17643749 FAM184B -0.28 -8.5 -0.32 1.38e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.52 0.41 4.72e-28 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.93 0.33 4.51e-18 Motion sickness; BRCA cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg01181863 chr3:195395398 SDHAP2 -0.6 -10.99 -0.4 7.22e-26 Pancreatic cancer; BRCA cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg14926445 chr8:58193284 C8orf71 -0.43 -8.2 -0.31 1.33e-15 Developmental language disorder (linguistic errors); BRCA cis rs1691799 0.899 rs1168357 chr12:66749879 T/C cg16791601 chr12:66731901 HELB -0.68 -18.93 -0.6 8.89e-64 White blood cell count (basophil); BRCA cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg15605315 chr1:45957053 TESK2 -0.46 -9.26 -0.34 2.97e-19 High light scatter reticulocyte count; BRCA cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13046373 0.508 rs1911572 chr21:32031648 A/G cg14062083 chr21:31802829 KRTAP13-4 -0.36 -9.85 -0.36 2.09e-21 HDL cholesterol; BRCA cis rs4730250 0.707 rs61014091 chr7:106810107 A/C cg02696742 chr7:106810147 HBP1 -0.57 -9.95 -0.37 8.9e-22 Osteoarthritis; BRCA cis rs2625529 0.761 rs972029 chr15:72172986 C/T cg16672083 chr15:72433130 SENP8 -0.76 -16.55 -0.55 1.83e-51 Red blood cell count; BRCA cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg00631329 chr6:26305371 NA -0.4 -12.05 -0.43 2.68e-30 Educational attainment; BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.43 -8.85 -0.33 8.37e-18 Tonsillectomy; BRCA cis rs4919087 0.892 rs2065861 chr10:99004608 C/T cg25902810 chr10:99078978 FRAT1 0.43 9.15 0.34 7.7e-19 Monocyte count; BRCA cis rs7582180 0.629 rs893416 chr2:100957443 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.65 0.42 1.44e-28 Intelligence (multi-trait analysis); BRCA trans rs9929218 0.581 rs12185157 chr16:68784587 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.9 24.74 0.7 2.71e-95 Colorectal cancer; BRCA cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -8.41 -0.32 2.69e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2019216 0.967 rs1606426 chr17:21927959 A/G cg22648282 chr17:21454238 C17orf51 -0.36 -8.2 -0.31 1.33e-15 Pelvic organ prolapse; BRCA cis rs7666738 0.830 rs28497822 chr4:98906873 C/T cg17366294 chr4:99064904 C4orf37 0.41 9.69 0.36 8.24e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.717 rs2253862 chr1:46081960 C/T cg03146154 chr1:46216737 IPP -0.5 -11.01 -0.4 6.25e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7980799 0.967 rs7971226 chr12:33586881 C/T cg26384229 chr12:38710491 ALG10B 0.42 8.78 0.33 1.51e-17 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg23711669 chr6:146136114 FBXO30 0.66 13.22 0.46 1.96e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg26149184 chr10:133730230 NA 0.41 8.45 0.32 1.97e-16 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9443645 0.901 rs13191068 chr6:79714867 T/C cg18132916 chr6:79620363 NA -0.49 -11.15 -0.4 1.64e-26 Intelligence (multi-trait analysis); BRCA cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg12935359 chr14:103987150 CKB 0.65 15.14 0.51 1.84e-44 Intelligence (multi-trait analysis); BRCA trans rs12310956 0.532 rs11052930 chr12:33964824 A/G cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg04317338 chr11:64019027 PLCB3 0.53 9.41 0.35 9.07e-20 Attention deficit hyperactivity disorder; BRCA cis rs12541635 0.966 rs11786829 chr8:107023752 C/G cg10147462 chr8:107024639 NA 0.37 10.33 0.38 3e-23 Age of smoking initiation; BRCA cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg26850624 chr5:429559 AHRR 0.33 7.97 0.3 7.54e-15 Cystic fibrosis severity; BRCA cis rs35306767 0.953 rs12762973 chr10:960761 C/G cg26597838 chr10:835615 NA 0.9 15.15 0.51 1.61e-44 Eosinophil percentage of granulocytes; BRCA trans rs3733585 0.762 rs6449217 chr4:10009151 T/A cg26043149 chr18:55253948 FECH 0.38 8.21 0.31 1.26e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7786808 0.644 rs4909081 chr7:158200785 G/A cg02030672 chr11:45687055 CHST1 0.52 11.77 0.42 4.23e-29 Obesity-related traits; BRCA cis rs6964587 0.610 rs7788951 chr7:91468765 A/T cg17063962 chr7:91808500 NA 0.54 12.39 0.44 9.73e-32 Breast cancer; BRCA trans rs9397585 0.599 rs685826 chr6:153411255 C/T cg17727855 chr9:108007124 SLC44A1 0.46 8.4 0.32 2.93e-16 Body mass index; BRCA cis rs2559856 1.000 rs2695291 chr12:102087543 G/A cg12924262 chr12:102091054 CHPT1 0.4 9.26 0.34 3.02e-19 Blood protein levels; BRCA cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.96 -0.4 9.57e-26 Personality dimensions; BRCA cis rs7666738 0.819 rs13120307 chr4:99036100 A/C cg05340658 chr4:99064831 C4orf37 0.68 16.67 0.55 4.69e-52 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.863 rs2127823 chr4:120485670 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.13 0.31 2.29e-15 Corneal astigmatism; BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.54 -11.38 -0.41 1.92e-27 Lymphocyte counts; BRCA cis rs2147904 0.934 rs783625 chr1:42365548 C/T cg16685388 chr1:42384056 HIVEP3 0.31 8.8 0.33 1.32e-17 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg06970220 chr1:156163860 SLC25A44 0.39 9.45 0.35 6.04e-20 Testicular germ cell tumor; BRCA cis rs60871478 0.588 rs56205589 chr7:910419 G/A cg27478167 chr7:817139 HEATR2 0.5 9.63 0.36 1.4e-20 Cerebrospinal P-tau181p levels; BRCA cis rs12479064 0.724 rs3792150 chr2:100041849 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.54 -11.25 -0.41 6.27e-27 Chronic sinus infection; BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA trans rs3774749 0.565 rs2518796 chr3:50207075 A/G cg21659725 chr3:3221576 CRBN 0.34 7.99 0.3 6.52e-15 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs12366667 chr12:38332632 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.41 0.38 1.45e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2841277 0.708 rs11851053 chr14:105407208 T/C cg14403583 chr14:105418241 AHNAK2 -0.38 -8.97 -0.33 3.29e-18 Rheumatoid arthritis; BRCA cis rs11098499 0.691 rs10028773 chr4:120265259 C/G cg09307838 chr4:120376055 NA -0.59 -12.9 -0.45 5.16e-34 Corneal astigmatism; BRCA cis rs10504229 1.000 rs1961778 chr8:58168756 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.63 -0.32 4.78e-17 Developmental language disorder (linguistic errors); BRCA cis rs290268 0.874 rs290991 chr9:93561450 A/C cg02608019 chr9:93564028 SYK -0.54 -11.9 -0.43 1.26e-29 Platelet count; BRCA cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg25019033 chr10:957182 NA -0.42 -8.68 -0.32 3.24e-17 Eosinophil percentage of granulocytes; BRCA cis rs6121246 0.583 rs28815498 chr20:30351560 T/C cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs7631605 0.935 rs2286939 chr3:37062040 T/C cg15934958 chr3:37212084 LRRFIP2 0.41 9.63 0.36 1.42e-20 Cerebrospinal P-tau181p levels; BRCA cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg07148914 chr20:33460835 GGT7 0.38 8.55 0.32 8.73e-17 Height; BRCA cis rs1580019 0.922 rs1466147 chr7:32486262 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.43 8.89 0.33 6.34e-18 Cognitive ability; BRCA cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg16339924 chr4:17578868 LAP3 0.59 14.49 0.5 2.43e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9818758 0.607 rs56004653 chr3:49072228 T/C cg01304814 chr3:48885189 PRKAR2A 0.77 7.94 0.3 8.96e-15 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg07092213 chr7:1199455 ZFAND2A -0.51 -11.62 -0.42 1.85e-28 Longevity;Endometriosis; BRCA cis rs634534 0.562 rs1151505 chr11:65734539 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.5 11.06 0.4 3.84e-26 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs6834538 0.597 rs4833414 chr4:113469913 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.43 10.37 0.38 2.14e-23 Free thyroxine concentration; BRCA cis rs11874712 0.931 rs8095608 chr18:43678911 A/G cg20479805 chr18:43684716 ATP5A1;HAUS1 0.33 7.92 0.3 1.02e-14 Migraine - clinic-based; BRCA cis rs858239 0.570 rs10235467 chr7:23148808 C/T cg23682824 chr7:23144976 KLHL7 0.42 11.08 0.4 3.14e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs367943 1.000 rs191553 chr5:112823659 A/G cg12552261 chr5:112820674 MCC -0.55 -12.07 -0.43 2.28e-30 Type 2 diabetes; BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.71 -0.33 2.62e-17 Total body bone mineral density; BRCA cis rs6545883 0.929 rs2421203 chr2:61669248 C/A cg15711740 chr2:61764176 XPO1 -0.55 -14.13 -0.49 1.17e-39 Tuberculosis; BRCA cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg04511125 chr2:88470314 THNSL2 0.95 13.69 0.48 1.31e-37 Plasma clusterin levels; BRCA cis rs12541635 0.677 rs7819501 chr8:107006962 C/T cg10147462 chr8:107024639 NA -0.39 -10.29 -0.38 4.22e-23 Age of smoking initiation; BRCA cis rs6973256 0.829 rs17167199 chr7:133333292 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.76 -0.33 1.73e-17 Intelligence (multi-trait analysis); BRCA trans rs4332037 0.707 rs56070303 chr7:1891015 C/T cg25206134 chr2:45395956 NA 0.53 8.77 0.33 1.57e-17 Bipolar disorder; BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg11843238 chr5:131593191 PDLIM4 0.35 9.07 0.34 1.42e-18 Breast cancer; BRCA cis rs3806843 0.966 rs2563262 chr5:140137712 C/G cg11822812 chr5:140052017 DND1 -0.31 -8.4 -0.32 2.79e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs9815354 0.812 rs73071222 chr3:41986896 C/T cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs2625529 0.617 rs2929509 chr15:72239272 T/C cg16672083 chr15:72433130 SENP8 0.66 15.66 0.53 4.97e-47 Red blood cell count; BRCA cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.75e-16 Menopause (age at onset); BRCA cis rs9463078 0.874 rs9357478 chr6:45196708 A/G cg25276700 chr6:44698697 NA -0.36 -8.09 -0.3 2.98e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg11366901 chr6:160182831 ACAT2 0.83 15.91 0.53 3.09e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs3771570 0.892 rs55751610 chr2:242346057 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.26 0.34 3.11e-19 Prostate cancer; BRCA cis rs7617773 0.779 rs1045482 chr3:48312229 A/G cg11946769 chr3:48343235 NME6 0.51 11.63 0.42 1.7e-28 Coronary artery disease; BRCA cis rs2652834 0.851 rs4238372 chr15:63351488 G/A cg05507819 chr15:63340323 TPM1 0.53 9.22 0.34 4.21e-19 HDL cholesterol; BRCA cis rs17270561 0.636 rs9358880 chr6:25743161 C/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg02659138 chr7:134003124 SLC35B4 0.36 10.19 0.37 1.07e-22 Mean platelet volume; BRCA cis rs56104184 0.668 rs73063523 chr19:49408943 T/C cg21252483 chr19:49399788 TULP2 -0.52 -11.28 -0.41 4.76e-27 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs11098499 0.874 rs10022508 chr4:120115228 A/G cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.65e-26 Corneal astigmatism; BRCA cis rs651907 0.557 rs3094296 chr3:101400167 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 13.98 0.48 5.77e-39 Colorectal cancer; BRCA cis rs17376456 0.569 rs12653528 chr5:93212833 T/C cg25358565 chr5:93447407 FAM172A -0.64 -11.4 -0.41 1.61e-27 Diabetic retinopathy; BRCA cis rs7246657 0.654 rs10407568 chr19:38123009 A/T cg18154014 chr19:37997991 ZNF793 0.5 9.55 0.35 2.62e-20 Coronary artery calcification; BRCA cis rs27434 0.583 rs26653 chr5:96139250 C/G cg16492584 chr5:96139282 ERAP1 -0.51 -13.24 -0.46 1.49e-35 Ankylosing spondylitis; BRCA cis rs11984145 1.000 rs16879966 chr7:38843256 C/G cg19327137 chr7:38886074 VPS41 -0.5 -9.26 -0.34 3.17e-19 Cognitive performance; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg02951883 chr7:2050386 MAD1L1 -0.55 -12.43 -0.44 6.65e-32 Bipolar disorder and schizophrenia; BRCA trans rs11098499 0.779 rs7699346 chr4:120310542 C/T cg25214090 chr10:38739885 LOC399744 0.52 11.71 0.42 7.85e-29 Corneal astigmatism; BRCA cis rs10496034 0.850 rs75903234 chr2:55217518 T/C cg16098955 chr2:55172992 EML6 0.52 8.6 0.32 6e-17 Refractive astigmatism; BRCA cis rs7582180 0.629 rs13010911 chr2:100953390 G/C cg08017756 chr2:100939284 LONRF2 -0.3 -7.82 -0.3 2.17e-14 Intelligence (multi-trait analysis); BRCA trans rs208520 1.000 rs208523 chr6:66954195 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -14.55 -0.5 1.17e-41 Exhaled nitric oxide output; BRCA trans rs1945213 0.694 rs9888298 chr11:55865704 T/C cg03929089 chr4:120376271 NA 0.61 10.52 0.38 5.41e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs9859260 0.614 rs493661 chr3:195786489 T/A cg12923728 chr3:195709715 SDHAP1 0.38 7.88 0.3 1.45e-14 Mean corpuscular volume; BRCA cis rs8016982 0.698 rs12590764 chr14:81704417 G/A cg01989461 chr14:81687754 GTF2A1 0.6 14.22 0.49 4.63e-40 Schizophrenia; BRCA cis rs34172651 0.517 rs11639856 chr16:24788645 A/T cg04756594 chr16:24857601 SLC5A11 -0.51 -11.74 -0.42 6.07e-29 Intelligence (multi-trait analysis); BRCA cis rs2404602 0.647 rs920712 chr15:77033934 G/A cg23625390 chr15:77176239 SCAPER -0.56 -14.04 -0.49 3.19e-39 Blood metabolite levels; BRCA cis rs599083 0.530 rs583545 chr11:68178635 T/C cg01657329 chr11:68192670 LRP5 0.36 8.13 0.31 2.27e-15 Bone mineral density (spine); BRCA cis rs589448 0.902 rs315113 chr12:69786543 G/T cg14784868 chr12:69753453 YEATS4 -0.77 -25.25 -0.71 4.04e-98 Cerebrospinal fluid biomarker levels; BRCA cis rs6840360 0.571 rs1978955 chr4:152509509 G/A cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 6.04e-15 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs10213956 chr5:93460839 C/T cg25358565 chr5:93447407 FAM172A 1.22 19.71 0.61 6.2e-68 Diabetic retinopathy; BRCA cis rs7178424 0.935 rs12900645 chr15:62286208 A/G cg00456672 chr15:62358751 C2CD4A -0.38 -8.71 -0.33 2.66e-17 Height; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -11.42 -0.41 1.33e-27 Bipolar disorder and schizophrenia; BRCA trans rs17685 0.753 rs4732595 chr7:75755139 A/G cg19862616 chr7:65841803 NCRNA00174 0.79 25.62 0.71 4.05e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs40363 0.723 rs2736 chr16:3536872 G/A cg21433313 chr16:3507492 NAT15 -0.59 -8.09 -0.3 2.95e-15 Tuberculosis; BRCA cis rs4478858 0.684 rs7528066 chr1:31749092 C/G cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs921968 0.541 rs832798 chr2:219464810 G/A cg02176678 chr2:219576539 TTLL4 0.47 12.16 0.43 9.04e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg18357645 chr12:58087776 OS9 -0.31 -7.95 -0.3 8.74e-15 Multiple sclerosis; BRCA cis rs34779708 0.931 rs35317849 chr10:35285721 C/A cg03585969 chr10:35415529 CREM 0.56 11.49 0.41 6.62e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7072216 0.763 rs6584200 chr10:100170037 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs7917772 0.532 rs10748829 chr10:104527244 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.61 -0.39 2.5300000000000002e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs738321 0.757 rs6001020 chr22:38538246 C/G cg25457927 chr22:38595422 NA -0.36 -12.14 -0.43 1.15e-30 Breast cancer; BRCA cis rs4730250 0.707 rs10253291 chr7:106786550 C/A cg02696742 chr7:106810147 HBP1 0.57 9.42 0.35 8.1e-20 Osteoarthritis; BRCA cis rs1712517 0.838 rs1891293 chr10:105001797 C/T cg05636881 chr10:105038444 INA -0.39 -8.82 -0.33 1.09e-17 Migraine; BRCA trans rs2562456 0.876 rs2681395 chr19:21738140 T/C cg25042112 chr7:64838748 ZNF92 -0.45 -8.34 -0.31 4.45e-16 Pain; BRCA cis rs919433 0.963 rs1429417 chr2:198158171 T/G cg03934865 chr2:198174659 NA -0.38 -8.31 -0.31 5.76e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg06108461 chr20:60628389 TAF4 0.72 15.22 0.52 7.64e-45 Body mass index; BRCA cis rs4363385 0.755 rs516198 chr1:153026196 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.5 -0.32 1.34e-16 Inflammatory skin disease; BRCA cis rs798554 0.757 rs1182179 chr7:2873648 A/G cg21143896 chr7:2802374 GNA12 -0.35 -8.93 -0.33 4.34e-18 Height; BRCA cis rs7044106 0.762 rs1530370 chr9:123424552 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.79 0.42 3.74e-29 Hip circumference adjusted for BMI; BRCA cis rs651907 0.535 rs34743741 chr3:101532448 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 13.0 0.46 1.94e-34 Colorectal cancer; BRCA cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg27478167 chr7:817139 HEATR2 0.54 10.51 0.38 6.25e-24 Cerebrospinal P-tau181p levels; BRCA cis rs7607369 0.580 rs17573731 chr2:219652153 T/C cg02176678 chr2:219576539 TTLL4 -0.48 -12.9 -0.45 5.31e-34 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg26587870 chr6:27730563 NA -0.41 -8.73 -0.33 2.21e-17 Parkinson's disease; BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 16.89 0.56 3.28e-53 Alzheimer's disease; BRCA cis rs9814567 0.929 rs9838834 chr3:134207077 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.43 -0.61 2e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs801193 0.636 rs10233806 chr7:66118248 G/C cg12463550 chr7:65579703 CRCP -0.37 -7.86 -0.3 1.58e-14 Aortic root size; BRCA cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg11657440 chr19:46296263 DMWD -0.55 -12.98 -0.46 2.33e-34 Coronary artery disease; BRCA cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg00857998 chr1:205179979 DSTYK 0.42 8.11 0.31 2.62e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs2658782 1.000 rs2658782 chr11:93166731 T/G cg15737290 chr11:93063684 CCDC67 0.53 10.17 0.37 1.24e-22 Pulmonary function decline; BRCA cis rs7246657 0.943 rs2303131 chr19:37936025 G/A cg18154014 chr19:37997991 ZNF793 0.62 11.61 0.42 1.98e-28 Coronary artery calcification; BRCA cis rs1059312 0.808 rs2170989 chr12:129291317 T/C cg09035930 chr12:129282057 SLC15A4 -0.49 -13.85 -0.48 2.34e-38 Systemic lupus erythematosus; BRCA cis rs6963495 0.769 rs11556986 chr7:105177041 A/T cg19920283 chr7:105172520 RINT1 0.58 10.4 0.38 1.63e-23 Bipolar disorder (body mass index interaction); BRCA cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg12935359 chr14:103987150 CKB -0.61 -13.84 -0.48 2.63e-38 Intelligence (multi-trait analysis); BRCA cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg12935359 chr14:103987150 CKB -0.59 -13.91 -0.48 1.32e-38 Body mass index; BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg12444411 chr7:2802554 GNA12 -0.37 -9.06 -0.34 1.6e-18 Height; BRCA cis rs2408955 0.522 rs4760679 chr12:48461635 G/T cg24011408 chr12:48396354 COL2A1 -0.4 -7.93 -0.3 9.88e-15 Glycated hemoglobin levels; BRCA trans rs629535 0.814 rs558511 chr8:70069908 C/A cg21567404 chr3:27674614 NA 1.01 20.96 0.64 1.2e-74 Dupuytren's disease; BRCA cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg26647111 chr11:31128758 NA -0.44 -9.64 -0.36 1.31e-20 Red blood cell count; BRCA cis rs1008375 0.898 rs4698620 chr4:17587361 C/T cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9443645 0.527 rs1413969 chr6:79790982 A/G cg05283184 chr6:79620031 NA -0.36 -8.42 -0.32 2.41e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg25036284 chr2:26402008 FAM59B 0.89 15.6 0.53 1.03e-46 Gut microbiome composition (summer); BRCA cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg13319975 chr6:146136371 FBXO30 -0.42 -9.42 -0.35 7.89e-20 Lobe attachment (rater-scored or self-reported); BRCA trans rs7829975 0.667 rs1877119 chr8:8707197 C/G cg16141378 chr3:129829833 LOC729375 -0.34 -8.22 -0.31 1.16e-15 Mood instability; BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg08470875 chr2:26401718 FAM59B 0.76 11.94 0.43 8.04e-30 Gut microbiome composition (summer); BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg12564285 chr5:131593104 PDLIM4 0.42 10.22 0.37 8.51e-23 Acylcarnitine levels; BRCA trans rs4650994 1.000 rs4511075 chr1:178518636 G/A cg05059571 chr16:84539110 KIAA1609 -0.43 -9.77 -0.36 4.34e-21 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg23649088 chr2:200775458 C2orf69 0.71 15.21 0.52 7.94e-45 Osteoporosis; BRCA cis rs1018836 0.923 rs4734266 chr8:91628147 C/T cg16814680 chr8:91681699 NA -0.6 -12.75 -0.45 2.37e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs7727544 0.654 rs4705849 chr5:131559199 T/A cg14196790 chr5:131705035 SLC22A5 0.4 10.0 0.37 5.54e-22 Blood metabolite levels; BRCA cis rs7071206 0.947 rs10509391 chr10:79422369 G/A cg00983440 chr10:79422392 NA -0.57 -10.88 -0.4 2e-25 Bone mineral density; BRCA cis rs600806 0.713 rs11102984 chr1:109997373 T/C cg20591472 chr1:110008990 SYPL2 0.33 8.3 0.31 6.14e-16 Intelligence (multi-trait analysis); BRCA cis rs62064224 0.554 rs9901737 chr17:30681354 C/G cg25809561 chr17:30822961 MYO1D 0.37 8.64 0.32 4.49e-17 Schizophrenia; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg03923535 chr7:1197113 ZFAND2A 0.4 8.0 0.3 6.02e-15 Longevity;Endometriosis; BRCA cis rs72781680 0.898 rs72780191 chr2:24007122 T/C cg08917208 chr2:24149416 ATAD2B 1.05 14.36 0.49 9.8e-41 Lymphocyte counts; BRCA trans rs1547374 0.694 rs225349 chr21:43776890 C/T cg09521743 chr10:75415752 SYNPO2L 0.43 8.81 0.33 1.19e-17 Pancreatic cancer; BRCA cis rs9291683 0.609 rs12500810 chr4:10031068 G/A cg00071950 chr4:10020882 SLC2A9 0.64 16.12 0.54 2.55e-49 Bone mineral density; BRCA cis rs68170813 0.562 rs17429825 chr7:107050731 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.12 -0.31 2.49e-15 Coronary artery disease; BRCA cis rs2985684 0.748 rs2985686 chr14:50100683 C/G cg04989706 chr14:50066350 PPIL5 -0.48 -9.01 -0.34 2.38e-18 Carotid intima media thickness; BRCA cis rs4363385 0.818 rs558363 chr1:153010431 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg11693508 chr17:37793320 STARD3 0.57 10.81 0.39 4.14e-25 Bipolar disorder; BRCA cis rs4900538 0.819 rs72700604 chr14:102882307 G/A cg18135206 chr14:102964638 TECPR2 -0.93 -22.04 -0.66 1.58e-80 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs17270561 0.609 rs1165211 chr6:25800922 T/C cg16482183 chr6:26056742 HIST1H1C 0.41 8.78 0.33 1.51e-17 Iron status biomarkers; BRCA cis rs9467773 1.000 rs4871 chr6:26545632 G/A cg11502198 chr6:26597334 ABT1 0.47 9.46 0.35 5.99e-20 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg05234568 chr11:5960015 NA 0.56 12.16 0.43 9.75e-31 DNA methylation (variation); BRCA cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg11890956 chr21:40555474 PSMG1 -0.65 -14.76 -0.5 1.21e-42 Menarche (age at onset); BRCA cis rs6089584 0.861 rs2180302 chr20:60576369 A/G cg13770153 chr20:60521292 NA -0.4 -9.28 -0.34 2.5e-19 Body mass index; BRCA cis rs2276314 0.748 rs4799839 chr18:33597531 T/C cg05985134 chr18:33552581 C18orf21 0.64 11.51 0.41 5.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.06 -0.34 1.62e-18 Menopause (age at onset); BRCA cis rs28374715 0.681 rs28687846 chr15:41599902 C/T cg18705301 chr15:41695430 NDUFAF1 -1.04 -24.43 -0.7 1.28e-93 Ulcerative colitis; BRCA cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7246657 0.679 rs12461113 chr19:38083188 G/A cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg24642844 chr7:1081250 C7orf50 -0.89 -15.97 -0.53 1.45e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg15017067 chr4:17643749 FAM184B 0.31 9.41 0.35 8.83e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6138458 1.000 rs2387361 chr20:24899905 C/T cg06937882 chr20:24974362 C20orf3 0.44 8.35 0.31 4.34e-16 Blood protein levels; BRCA cis rs1506636 1.000 rs635072 chr7:123403255 G/A cg03229431 chr7:123269106 ASB15 0.61 13.76 0.48 6.43e-38 Plateletcrit;Platelet count; BRCA cis rs7772486 0.754 rs12199362 chr6:146118225 A/G cg13319975 chr6:146136371 FBXO30 -0.46 -10.54 -0.38 4.52e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs60843830 0.661 rs7588043 chr2:104979 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.49 9.27 0.34 2.83e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1003719 0.788 rs4817849 chr21:38469796 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.75 -0.53 1.79e-47 Chronic sinus infection; BRCA cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.23 -0.31 1.05e-15 Bipolar disorder; BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 12.35 0.44 1.4e-31 Platelet count; BRCA cis rs4664304 0.658 rs2667015 chr2:160868586 T/C cg01092293 chr2:160761427 LY75 -0.36 -8.66 -0.32 3.83e-17 Crohn's disease;Inflammatory bowel disease; BRCA cis rs17376456 0.877 rs10514380 chr5:93409370 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.65 0.32 4.01e-17 Diabetic retinopathy; BRCA cis rs6582630 0.555 rs11182217 chr12:38480030 G/A cg26384229 chr12:38710491 ALG10B 0.71 16.34 0.54 2.18e-50 Drug-induced liver injury (flucloxacillin); BRCA trans rs8002861 0.713 rs7339417 chr13:44413496 A/T cg12856521 chr11:46389249 DGKZ 0.37 8.07 0.3 3.5e-15 Leprosy; BRCA cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg04756594 chr16:24857601 SLC5A11 0.53 12.17 0.43 8.7e-31 Intelligence (multi-trait analysis); BRCA cis rs79057730 0.599 rs34411410 chr7:811721 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.82 11.26 0.41 5.85e-27 Initial pursuit acceleration; BRCA cis rs3806933 0.522 rs13186912 chr5:110456704 A/T cg04022379 chr5:110408740 TSLP -0.47 -9.93 -0.37 1.03e-21 Eosinophilic esophagitis; BRCA cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.66 -0.57 3.68e-57 Chronic sinus infection; BRCA cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg15145296 chr3:125709740 NA -0.54 -8.93 -0.33 4.68e-18 Blood pressure (smoking interaction); BRCA cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg14664628 chr15:75095509 CSK -0.74 -18.23 -0.58 4.43e-60 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6424115 0.644 rs2267960 chr1:24068544 T/C cg15997130 chr1:24165203 NA 0.36 8.72 0.33 2.43e-17 Immature fraction of reticulocytes; BRCA cis rs6964587 0.869 rs10256780 chr7:91527176 T/A cg17063962 chr7:91808500 NA -0.51 -11.82 -0.42 2.74e-29 Breast cancer; BRCA cis rs897984 0.542 rs35713203 chr16:31090407 G/C cg02466173 chr16:30829666 NA -0.41 -8.86 -0.33 7.98e-18 Dementia with Lewy bodies; BRCA cis rs6594713 0.717 rs2914198 chr5:112950253 C/G cg12552261 chr5:112820674 MCC -0.48 -8.02 -0.3 4.93e-15 Brain cytoarchitecture; BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg00908189 chr16:619842 PIGQ 0.7 17.9 0.58 2.18e-58 Height; BRCA trans rs9951602 0.512 rs77157626 chr18:76644771 C/T cg02800362 chr5:177631904 HNRNPAB 0.76 17.47 0.57 3.5e-56 Obesity-related traits; BRCA cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg20476274 chr7:133979776 SLC35B4 0.52 12.67 0.45 5.76e-33 Mean platelet volume; BRCA cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.49 -0.32 1.42e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6866344 0.570 rs56236920 chr5:178144617 C/T cg03877680 chr5:178157825 ZNF354A 0.82 15.94 0.53 2.16e-48 Neutrophil percentage of white cells; BRCA cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7914558 0.966 rs11191438 chr10:104637864 C/G cg04362960 chr10:104952993 NT5C2 0.41 10.14 0.37 1.62e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg04944784 chr2:26401820 FAM59B -0.96 -16.37 -0.54 1.41e-50 Gut microbiome composition (summer); BRCA cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg00684032 chr4:1343700 KIAA1530 0.32 8.38 0.31 3.46e-16 Obesity-related traits; BRCA cis rs1941023 0.584 rs2233253 chr11:60157166 C/T cg08716584 chr11:60157161 MS4A7 -0.44 -10.63 -0.39 2.13e-24 Congenital heart disease (maternal effect); BRCA cis rs1691799 0.867 rs1027400 chr12:66760922 A/T cg16791601 chr12:66731901 HELB -0.64 -17.34 -0.57 1.78e-55 White blood cell count (basophil); BRCA cis rs4478858 0.647 rs10798835 chr1:31709055 T/C cg00250761 chr1:31883323 NA -0.31 -8.11 -0.31 2.64e-15 Alcohol dependence; BRCA trans rs637571 0.522 rs7105628 chr11:65763067 C/T cg17712092 chr4:129076599 LARP1B 0.62 14.79 0.5 8.45e-43 Eosinophil percentage of white cells; BRCA cis rs35110281 0.626 rs10854486 chr21:45118280 G/T cg21573476 chr21:45109991 RRP1B -0.39 -10.28 -0.38 4.86e-23 Mean corpuscular volume; BRCA cis rs9527 0.571 rs10786715 chr10:104620735 G/C cg04362960 chr10:104952993 NT5C2 0.42 10.03 0.37 4.46e-22 Arsenic metabolism; BRCA cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg01475377 chr6:109611718 NA -0.59 -16.46 -0.55 5.05e-51 Reticulocyte fraction of red cells; BRCA cis rs6840258 0.547 rs4693795 chr4:87868056 G/A cg08197287 chr4:87952173 AFF1 -0.45 -8.15 -0.31 1.89e-15 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs861020 1.000 rs622832 chr1:209974232 A/C cg09163369 chr1:210001066 C1orf107 0.48 9.05 0.34 1.69e-18 Orofacial clefts; BRCA cis rs66887589 0.807 rs13134517 chr4:120405262 G/A cg09307838 chr4:120376055 NA 0.47 9.76 0.36 4.59e-21 Diastolic blood pressure; BRCA cis rs4363385 0.720 rs6680624 chr1:152983872 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.28 -0.31 7.23e-16 Inflammatory skin disease; BRCA cis rs765787 0.530 rs2899378 chr15:45537584 C/T cg25801113 chr15:45476975 SHF -0.34 -8.27 -0.31 7.79e-16 Uric acid levels; BRCA cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg14517863 chr17:44321492 NA 0.37 7.82 0.3 2.2e-14 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs7618915 0.851 rs34228726 chr3:52322797 A/G cg18404041 chr3:52824283 ITIH1 -0.35 -9.55 -0.35 2.66e-20 Bipolar disorder; BRCA cis rs11098499 0.863 rs13149407 chr4:120437825 A/G cg09307838 chr4:120376055 NA 0.69 14.05 0.49 2.88e-39 Corneal astigmatism; BRCA cis rs2070488 1.000 rs13072809 chr3:38468171 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 19.84 0.62 1.36e-68 Electrocardiographic conduction measures; BRCA trans rs66573146 0.572 rs67252699 chr4:6946411 A/G cg07817883 chr1:32538562 TMEM39B 0.92 13.93 0.48 1.04e-38 Granulocyte percentage of myeloid white cells; BRCA cis rs796364 0.951 rs281769 chr2:200809709 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.84 0.42 2.28e-29 Schizophrenia; BRCA cis rs12497850 0.897 rs6795025 chr3:49081247 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.49 0.35 4.44e-20 Parkinson's disease; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg19723775 chr5:179050963 HNRNPH1 -0.38 -9.16 -0.34 6.87e-19 Lung cancer; BRCA cis rs8038465 0.615 rs11072430 chr15:73981701 A/G cg15420318 chr15:73925796 NPTN -0.38 -8.55 -0.32 8.77e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9329221 0.772 rs7824675 chr8:10243418 G/T cg21775007 chr8:11205619 TDH -0.39 -8.35 -0.31 4.34e-16 Neuroticism; BRCA cis rs12142240 0.698 rs4372193 chr1:46853233 G/T cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs9287719 0.967 rs12464908 chr2:10761496 T/G cg00105475 chr2:10696890 NA 0.44 10.26 0.38 5.78e-23 Prostate cancer; BRCA cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg05025164 chr4:1340916 KIAA1530 0.36 7.9 0.3 1.2e-14 Longevity; BRCA cis rs897984 0.542 rs73530203 chr16:31099859 G/A cg02466173 chr16:30829666 NA -0.41 -8.79 -0.33 1.4e-17 Dementia with Lewy bodies; BRCA cis rs4319547 0.774 rs7295105 chr12:123124225 G/A cg23029597 chr12:123009494 RSRC2 -0.55 -11.27 -0.41 5.15e-27 Body mass index; BRCA cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg13798912 chr7:905769 UNC84A -0.49 -7.9 -0.3 1.18e-14 Cerebrospinal P-tau181p levels; BRCA cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.46 -10.27 -0.38 5.35e-23 Alzheimer's disease (late onset); BRCA cis rs4478858 0.735 rs6685728 chr1:31802550 T/C cg00250761 chr1:31883323 NA -0.33 -8.54 -0.32 9.96e-17 Alcohol dependence; BRCA cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -10.16 -0.37 1.43e-22 Extrinsic epigenetic age acceleration; BRCA cis rs801193 0.967 rs2420827 chr7:66147101 G/A cg11764359 chr7:65958608 NA -0.62 -13.28 -0.47 1e-35 Aortic root size; BRCA cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.43e-61 Cognitive function; BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg13880726 chr7:1868755 MAD1L1 0.53 9.87 0.36 1.72e-21 Bipolar disorder and schizophrenia; BRCA cis rs4268898 0.662 rs2303291 chr2:24431184 C/T cg06627628 chr2:24431161 ITSN2 -0.84 -15.13 -0.51 1.98e-44 Asthma; BRCA cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg19077165 chr18:44547161 KATNAL2 -0.53 -11.53 -0.41 4.66e-28 Personality dimensions; BRCA cis rs4363385 0.782 rs10788857 chr1:153024941 T/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.5 -0.32 1.38e-16 Inflammatory skin disease; BRCA cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg24531977 chr5:56204891 C5orf35 0.65 13.86 0.48 2.27e-38 Initial pursuit acceleration; BRCA trans rs2018683 0.649 rs12536605 chr7:28970500 C/T cg19402173 chr7:128379420 CALU -0.42 -10.02 -0.37 4.85e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs12579753 0.879 rs10778828 chr12:82117216 C/A cg07988820 chr12:82153109 PPFIA2 -0.65 -11.16 -0.4 1.45e-26 Resting heart rate; BRCA cis rs992157 0.835 rs2292550 chr2:219140288 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.51 -10.8 -0.39 4.42e-25 Colorectal cancer; BRCA cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg18404041 chr3:52824283 ITIH1 -0.29 -8.54 -0.32 1e-16 Electroencephalogram traits; BRCA cis rs796364 1.000 rs281762 chr2:200799201 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.69 0.42 9.95e-29 Schizophrenia; BRCA cis rs6840258 0.941 rs72667757 chr4:87946994 C/A cg08197287 chr4:87952173 AFF1 -0.44 -7.86 -0.3 1.68e-14 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs829883 0.621 rs11109516 chr12:98921035 G/A cg25150519 chr12:98850993 NA -0.51 -9.29 -0.34 2.48e-19 Colorectal adenoma (advanced); BRCA cis rs7103648 0.643 rs12365079 chr11:47696596 A/T cg03711944 chr11:47377212 SPI1 -0.38 -9.04 -0.34 1.88e-18 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1580019 0.961 rs1610143 chr7:32498331 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.29 0.54 3.92e-50 Cognitive ability; BRCA cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs17711722 0.522 rs6957759 chr7:65271785 A/G cg18876405 chr7:65276391 NA 0.55 12.26 0.44 3.43e-31 Calcium levels; BRCA cis rs9393692 0.905 rs9358919 chr6:26287862 C/T cg13736514 chr6:26305472 NA -0.35 -11.95 -0.43 7.59e-30 Educational attainment; BRCA cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg25204440 chr1:209979598 IRF6 0.41 8.41 0.32 2.69e-16 Cleft lip with or without cleft palate; BRCA cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg00071950 chr4:10020882 SLC2A9 0.64 15.96 0.53 1.61e-48 Bone mineral density; BRCA cis rs6840258 0.660 rs17012216 chr4:87889437 G/T cg08197287 chr4:87952173 AFF1 -0.46 -8.4 -0.32 2.8e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg01028140 chr2:1542097 TPO -0.57 -11.62 -0.42 1.91e-28 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7103648 1.000 rs11039225 chr11:47430599 G/A cg03711944 chr11:47377212 SPI1 -0.42 -11.45 -0.41 9.25e-28 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1904096 0.506 rs10028613 chr4:95223698 T/C cg11021082 chr4:95130006 SMARCAD1 -0.4 -8.42 -0.32 2.47e-16 Type 2 diabetes; BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg25036284 chr2:26402008 FAM59B -0.61 -10.35 -0.38 2.47e-23 Gut microbiome composition (summer); BRCA cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg00745463 chr17:30367425 LRRC37B -0.61 -9.8 -0.36 3.19e-21 Hip circumference adjusted for BMI; BRCA cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg14036092 chr11:66035641 RAB1B 0.39 10.24 0.38 6.7e-23 Gout; BRCA cis rs9309473 1.000 rs6736866 chr2:73661986 C/G cg20560298 chr2:73613845 ALMS1 -0.49 -12.19 -0.43 7.35e-31 Metabolite levels; BRCA cis rs7020830 0.830 rs17487601 chr9:37213641 G/A cg14294708 chr9:37120828 ZCCHC7 1.16 39.03 0.84 2.8000000000000002e-171 Schizophrenia; BRCA cis rs12949688 0.967 rs9905938 chr17:55824351 G/A cg12582317 chr17:55822272 NA 0.32 7.83 0.3 2.04e-14 Schizophrenia; BRCA cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg04546413 chr19:29218101 NA 0.64 12.32 0.44 1.96e-31 Methadone dose in opioid dependence; BRCA trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg15704280 chr7:45808275 SEPT13 -0.53 -10.25 -0.38 6.4e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs2016266 0.859 rs10783575 chr12:53742885 C/T cg26875137 chr12:53738046 NA -0.42 -10.91 -0.4 1.59e-25 Bone mineral density (spine);Bone mineral density; BRCA cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15506890 chr2:3487001 NA 0.58 13.15 0.46 4.09e-35 Neurofibrillary tangles; BRCA cis rs7772486 0.875 rs1330939 chr6:146308518 T/A cg23711669 chr6:146136114 FBXO30 0.64 14.63 0.5 4.95e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs3845702 0.733 rs12693217 chr2:180841914 T/G cg01881094 chr2:180872142 CWC22 -1.02 -17.11 -0.56 2.7e-54 Schizophrenia; BRCA trans rs6598955 0.671 rs11247893 chr1:26597086 A/C cg07461501 chr17:79650226 HGS;ARL16 0.63 14.27 0.49 2.62e-40 Obesity-related traits; BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg25036284 chr2:26402008 FAM59B -0.95 -15.98 -0.53 1.27e-48 Gut microbiome composition (summer); BRCA cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg11266682 chr4:10021025 SLC2A9 -0.43 -11.38 -0.41 1.87e-27 Bone mineral density; BRCA cis rs35110281 0.720 rs162393 chr21:44942692 G/A cg04455712 chr21:45112962 RRP1B 0.42 10.66 0.39 1.6e-24 Mean corpuscular volume; BRCA cis rs8114671 0.967 rs1415774 chr20:33765616 C/T cg07148914 chr20:33460835 GGT7 -0.39 -8.34 -0.31 4.6e-16 Height; BRCA cis rs7833986 0.501 rs2953898 chr8:56980803 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.7 13.23 0.46 1.72e-35 Height; BRCA cis rs2204008 0.506 rs11495470 chr12:38026904 C/T cg26384229 chr12:38710491 ALG10B 0.66 15.19 0.52 1.03e-44 Bladder cancer; BRCA cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.13 0.46 4.84e-35 Bipolar disorder; BRCA cis rs11229555 0.645 rs12273638 chr11:58186335 T/C cg15696309 chr11:58395628 NA -0.45 -9.52 -0.35 3.53e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs3087591 1.000 rs2854331 chr17:29711728 G/A cg24425628 chr17:29625626 OMG;NF1 -0.43 -8.69 -0.33 3.01e-17 Hip circumference; BRCA cis rs829883 0.664 rs829876 chr12:98842138 A/G cg25150519 chr12:98850993 NA 0.67 16.41 0.54 8.83e-51 Colorectal adenoma (advanced); BRCA cis rs2108225 0.714 rs929393 chr7:107437048 C/T cg18560240 chr7:107437656 SLC26A3 -0.57 -12.5 -0.44 3.26e-32 Ulcerative colitis; BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg26516362 chr5:178986906 RUFY1 -0.34 -9.26 -0.34 3.02e-19 Lung cancer; BRCA cis rs6815814 0.861 rs12233670 chr4:38787216 C/T cg06935464 chr4:38784597 TLR10 0.49 10.18 0.37 1.21e-22 Breast cancer; BRCA cis rs9790314 0.967 rs336541 chr3:161056698 A/C cg03342759 chr3:160939853 NMD3 -0.65 -13.83 -0.48 3.01e-38 Morning vs. evening chronotype; BRCA cis rs2762353 0.935 rs3757131 chr6:25783909 C/T cg03517284 chr6:25882590 NA 0.48 10.71 0.39 1e-24 Blood metabolite levels; BRCA cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg11764359 chr7:65958608 NA 0.63 10.7 0.39 1.06e-24 Aortic root size; BRCA cis rs813218 0.523 rs1711554 chr3:99428998 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -8.88 -0.33 6.53e-18 Orofacial clefts; BRCA cis rs1580019 0.961 rs766657 chr7:32499510 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.76 16.8 0.55 1.03e-52 Cognitive ability; BRCA trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -15.68 -0.53 4.25e-47 Height; BRCA cis rs597539 0.652 rs660614 chr11:68659488 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.28 0.59 2.45e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs919433 0.679 rs6741314 chr2:198526088 G/A cg00792783 chr2:198669748 PLCL1 0.39 9.03 0.34 2.08e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs61931739 0.500 rs11836207 chr12:34315177 G/A cg26384229 chr12:38710491 ALG10B 0.43 9.37 0.35 1.19e-19 Morning vs. evening chronotype; BRCA cis rs1577917 0.958 rs2324839 chr6:86536942 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg16339924 chr4:17578868 LAP3 0.59 14.31 0.49 1.8e-40 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg13256891 chr4:100009986 ADH5 0.52 9.69 0.36 8.6e-21 Alcohol dependence; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg14004847 chr7:1930337 MAD1L1 -0.44 -8.46 -0.32 1.8e-16 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.924 rs13124368 chr4:99039615 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 4.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg27572855 chr1:25598939 RHD 0.47 13.33 0.47 5.88e-36 Erythrocyte sedimentation rate; BRCA cis rs4478858 0.735 rs11582342 chr1:31810681 A/G cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs6782228 0.606 rs7613073 chr3:128388503 T/G cg16766828 chr3:128327626 NA -0.43 -9.46 -0.35 5.76e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -14.07 -0.49 2.25e-39 Menarche (age at onset); BRCA cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg18876405 chr7:65276391 NA -0.62 -15.35 -0.52 1.68e-45 Aortic root size; BRCA cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg12463550 chr7:65579703 CRCP -0.37 -8.01 -0.3 5.4e-15 Aortic root size; BRCA cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg10523679 chr1:76189770 ACADM 0.58 10.52 0.38 5.54e-24 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg26769984 chr7:1090371 C7orf50 0.47 10.04 0.37 3.96e-22 Bronchopulmonary dysplasia; BRCA cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.22 0.37 8.56e-23 Aortic root size; BRCA cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg18132916 chr6:79620363 NA -0.47 -10.68 -0.39 1.29e-24 Intelligence (multi-trait analysis); BRCA cis rs9513627 0.573 rs12431100 chr13:100184918 C/G cg25919922 chr13:100150906 NA -0.69 -12.5 -0.44 3.24e-32 Obesity-related traits; BRCA cis rs5750830 0.649 rs5750822 chr22:39826788 C/T cg02038168 chr22:39784481 NA -0.39 -7.82 -0.3 2.19e-14 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.900 rs6465352 chr7:91775117 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.11 0.31 2.58e-15 Breast cancer; BRCA cis rs7123876 0.504 rs1157343 chr11:72429141 A/G cg03713592 chr11:72463424 ARAP1 -0.47 -9.19 -0.34 5.48e-19 Body mass index; BRCA cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg04756594 chr16:24857601 SLC5A11 0.34 8.44 0.32 2.06e-16 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.99 0.33 2.88e-18 Tonsillectomy; BRCA trans rs62103177 0.565 rs473119 chr18:77849459 T/G cg05926928 chr17:57297772 GDPD1 -0.78 -10.93 -0.4 1.25e-25 Opioid sensitivity; BRCA trans rs7615952 0.641 rs7632497 chr3:125783086 A/C cg07211511 chr3:129823064 LOC729375 -0.63 -11.17 -0.4 1.39e-26 Blood pressure (smoking interaction); BRCA cis rs36051895 0.623 rs62541543 chr9:5042082 G/A cg02405213 chr9:5042618 JAK2 -0.51 -9.14 -0.34 7.9e-19 Pediatric autoimmune diseases; BRCA cis rs3796619 1.000 rs1453605 chr4:1075771 C/T cg27284194 chr4:1044797 NA 0.44 9.49 0.35 4.63e-20 Recombination rate (males); BRCA cis rs9815354 0.638 rs73069277 chr3:41967521 C/T cg03022575 chr3:42003672 ULK4 0.72 9.93 0.37 1.03e-21 Pulse pressure;Diastolic blood pressure; BRCA trans rs3960554 0.867 rs10239209 chr7:75804085 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 12.29 0.44 2.69e-31 Eotaxin levels; BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg00814883 chr7:100076585 TSC22D4 -0.49 -9.38 -0.35 1.14e-19 Platelet count; BRCA trans rs9858542 0.953 rs9878943 chr3:49434654 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.07 -0.34 1.45e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg24558204 chr6:135376177 HBS1L -0.58 -15.94 -0.53 1.99e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg18402987 chr7:1209562 NA 0.53 10.2 0.37 9.98e-23 Longevity;Endometriosis; BRCA cis rs754466 0.606 rs11002310 chr10:79596030 A/C cg17075019 chr10:79541650 NA -0.8 -20.37 -0.63 1.93e-71 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg02297831 chr4:17616191 MED28 0.37 8.76 0.33 1.7e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2463822 0.925 rs12292586 chr11:62156312 C/T cg06239285 chr11:62104954 ASRGL1 -0.64 -9.18 -0.34 5.72e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg08601574 chr20:25228251 PYGB 0.37 8.79 0.33 1.41e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg22907277 chr7:1156413 C7orf50 0.6 9.15 0.34 7.54e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs28374715 0.528 rs7181982 chr15:41623020 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.8 -0.71 4.21e-101 Ulcerative colitis; BRCA cis rs7264396 0.563 rs2425079 chr20:34298191 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Total cholesterol levels; BRCA cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs9790314 1.000 rs4273380 chr3:160950314 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.06 -0.49 2.61e-39 Morning vs. evening chronotype; BRCA cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.01e-40 Motion sickness; BRCA cis rs9487051 0.698 rs11153168 chr6:109629420 A/T cg21918786 chr6:109611834 NA -0.36 -8.73 -0.33 2.16e-17 Reticulocyte fraction of red cells; BRCA cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg03146154 chr1:46216737 IPP 0.46 10.38 0.38 2.03e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.27 -0.31 7.52e-16 Total body bone mineral density; BRCA cis rs2046867 0.818 rs6792109 chr3:72867091 C/T cg25664220 chr3:72788482 NA -0.54 -11.68 -0.42 1.02e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2115630 0.967 rs11073702 chr15:85310071 G/A cg11189052 chr15:85197271 WDR73 -0.34 -8.23 -0.31 1.04e-15 P wave terminal force; BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg26314531 chr2:26401878 FAM59B 0.96 16.52 0.55 2.62e-51 Gut microbiome composition (summer); BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.17 -0.34 6.4e-19 Menopause (age at onset); BRCA cis rs9399135 0.967 rs2327580 chr6:135364417 A/C cg24558204 chr6:135376177 HBS1L 0.45 12.32 0.44 1.88e-31 Red blood cell count; BRCA cis rs17711722 0.640 rs13237956 chr7:65318029 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.11 0.37 2.18e-22 Calcium levels; BRCA cis rs12989701 1.000 rs6710467 chr2:127889932 C/T cg08168897 chr2:127865431 BIN1 0.6 10.78 0.39 5.02e-25 Alzheimer's disease (late onset); BRCA trans rs7829975 0.742 rs1533058 chr8:8685190 A/G cg16141378 chr3:129829833 LOC729375 -0.33 -8.06 -0.3 3.79e-15 Mood instability; BRCA cis rs2762353 0.845 rs35720558 chr6:25784800 A/C cg12310025 chr6:25882481 NA 0.52 12.31 0.44 2.12e-31 Blood metabolite levels; BRCA cis rs57590327 0.508 rs4622918 chr3:81965382 A/G cg07356753 chr3:81810745 GBE1 -0.37 -8.75 -0.33 1.82e-17 Extraversion; BRCA cis rs67478160 0.644 rs7159810 chr14:104294117 T/G cg26031613 chr14:104095156 KLC1 -0.43 -8.42 -0.32 2.41e-16 Schizophrenia; BRCA cis rs10208940 1.000 rs10208940 chr2:68733389 C/T cg12452813 chr2:68675892 NA -0.46 -8.21 -0.31 1.21e-15 Urate levels in lean individuals; BRCA cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.71 15.81 0.53 9.36e-48 Hip circumference adjusted for BMI; BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg02931644 chr1:25747376 RHCE 0.4 10.77 0.39 5.89e-25 Erythrocyte sedimentation rate; BRCA cis rs7894051 0.717 rs4838741 chr10:135206873 C/T cg05676341 chr10:135206831 MTG1 0.57 8.84 0.33 9.01e-18 Lifespan; BRCA cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg06115741 chr20:33292138 TP53INP2 0.48 10.6 0.39 2.68e-24 Coronary artery disease; BRCA cis rs752010 0.841 rs17363834 chr1:42076607 C/T cg06885757 chr1:42089581 HIVEP3 0.23 8.53 0.32 1.09e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg11845111 chr2:191398756 TMEM194B 0.43 9.7 0.36 7.86e-21 Pulse pressure; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg07308232 chr7:1071921 C7orf50 0.45 9.34 0.35 1.6e-19 Longevity;Endometriosis; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg05863683 chr7:1912471 MAD1L1 0.42 9.06 0.34 1.59e-18 Bipolar disorder and schizophrenia; BRCA cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg22800045 chr5:56110881 MAP3K1 -0.42 -8.4 -0.32 2.87e-16 Initial pursuit acceleration; BRCA cis rs9463078 0.683 rs227848 chr6:44698499 G/A cg25276700 chr6:44698697 NA 0.36 7.82 0.3 2.19e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs208520 1.000 rs12199876 chr6:66989469 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.39 0.49 6.85e-41 Exhaled nitric oxide output; BRCA cis rs1707322 1.000 rs4660905 chr1:46461587 C/T cg03146154 chr1:46216737 IPP -0.45 -10.0 -0.37 5.46e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7267979 1.000 rs6515651 chr20:25414539 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.05 -0.34 1.65e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9811920 0.683 rs813218 chr3:99592596 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.46 10.91 0.4 1.5e-25 Axial length; BRCA cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24308560 chr3:49941425 MST1R -0.4 -8.56 -0.32 8.62e-17 Intelligence (multi-trait analysis); BRCA cis rs3820068 0.705 rs4646109 chr1:15817319 T/C cg17385448 chr1:15911702 AGMAT 0.37 7.86 0.3 1.68e-14 Systolic blood pressure; BRCA cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg06671706 chr8:8559999 CLDN23 0.45 8.77 0.33 1.57e-17 Obesity-related traits; BRCA cis rs2836974 0.565 rs34304022 chr21:40579619 G/A cg11644478 chr21:40555479 PSMG1 0.58 8.86 0.33 7.92e-18 Cognitive function; BRCA cis rs7615952 0.641 rs2365019 chr3:125808135 T/C cg18479299 chr3:125709523 NA -0.54 -8.33 -0.31 4.84e-16 Blood pressure (smoking interaction); BRCA cis rs6088590 1.000 rs6087626 chr20:33347328 C/T cg08999081 chr20:33150536 PIGU 0.36 9.13 0.34 8.57e-19 Coronary artery disease; BRCA cis rs17604090 0.628 rs875263 chr7:29711066 T/C cg19413766 chr7:29689036 LOC646762 -0.57 -9.12 -0.34 1e-18 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs477692 0.569 rs871028 chr10:131293478 C/T cg05714579 chr10:131428358 MGMT -0.46 -10.41 -0.38 1.5e-23 Response to temozolomide; BRCA cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -10.2 -0.37 9.73e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs8072100 0.967 rs4289035 chr17:45707211 C/T cg19784903 chr17:45786737 TBKBP1 -0.34 -8.1 -0.31 2.87e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.15 -0.34 7.27e-19 Total body bone mineral density; BRCA cis rs12479064 0.724 rs62153852 chr2:99934713 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.5 -9.56 -0.35 2.45e-20 Chronic sinus infection; BRCA cis rs9790314 1.000 rs336570 chr3:161072054 A/G cg04691961 chr3:161091175 C3orf57 0.59 14.44 0.5 4.09e-41 Morning vs. evening chronotype; BRCA cis rs11123170 0.529 rs1015755 chr2:113968307 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.59 9.35 0.35 1.51e-19 Renal function-related traits (BUN); BRCA cis rs11764590 0.715 rs55810445 chr7:2103739 C/T cg02743256 chr7:2109353 MAD1L1 -0.47 -8.31 -0.31 5.75e-16 Neuroticism; BRCA cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.49 0.52 3.47e-46 Colorectal cancer; BRCA cis rs738321 0.701 rs4821754 chr22:38581503 A/G cg25457927 chr22:38595422 NA 0.38 12.47 0.44 4.06e-32 Breast cancer; BRCA cis rs6942756 1.000 rs73472312 chr7:128925217 T/C cg02491457 chr7:128862824 NA -0.71 -13.89 -0.48 1.61e-38 White matter hyperintensity burden; BRCA cis rs870825 0.616 rs72703531 chr4:185611092 C/T cg20176042 chr4:185552304 CASP3 -0.54 -8.22 -0.31 1.1e-15 Blood protein levels; BRCA cis rs763014 0.966 rs15564 chr16:677854 G/T cg04709771 chr16:646395 RAB40C 0.42 10.6 0.39 2.78e-24 Height; BRCA cis rs7587476 0.954 rs3768708 chr2:215645046 C/T cg04004882 chr2:215674386 BARD1 -0.57 -11.23 -0.41 8.22e-27 Neuroblastoma; BRCA trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg00717180 chr2:96193071 NA -0.41 -11.35 -0.41 2.48e-27 HDL cholesterol; BRCA cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.92 0.4 1.46e-25 Bipolar disorder; BRCA cis rs600806 0.888 rs10745352 chr1:109871787 T/C cg20591472 chr1:110008990 SYPL2 0.33 8.16 0.31 1.75e-15 Intelligence (multi-trait analysis); BRCA cis rs10870270 1.000 rs9971066 chr10:133788233 G/A cg26149184 chr10:133730230 NA 0.41 8.15 0.31 1.85e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs68170813 0.559 rs77671232 chr7:106939202 A/G cg02696742 chr7:106810147 HBP1 -0.48 -8.49 -0.32 1.39e-16 Coronary artery disease; BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg04944784 chr2:26401820 FAM59B -0.69 -11.52 -0.41 4.78e-28 Gut microbiome composition (summer); BRCA cis rs753274 0.650 rs7257738 chr19:14418921 G/C cg25450033 chr19:14444658 NA 0.33 7.84 0.3 1.93e-14 Tumor necrosis factor beta levels; BRCA cis rs701145 0.878 rs442480 chr3:153992952 T/A cg17054900 chr3:154042577 DHX36 0.68 11.79 0.42 3.71e-29 Coronary artery disease; BRCA cis rs1865760 0.865 rs9467651 chr6:25958257 C/G cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.38e-21 Height; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.96e-21 Total body bone mineral density; BRCA cis rs7914558 0.966 rs10786745 chr10:104956827 A/G cg04362960 chr10:104952993 NT5C2 0.41 9.78 0.36 3.85e-21 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9467773 1.000 rs9467796 chr6:26568411 A/G cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.8e-21 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg10729496 chr3:10149963 C3orf24 0.47 8.84 0.33 8.98e-18 Alzheimer's disease; BRCA cis rs4819052 0.851 rs2838829 chr21:46664040 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.84 0.36 2.28e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg04287289 chr16:89883240 FANCA -0.73 -18.1 -0.58 2e-59 Vitiligo; BRCA cis rs9309473 1.000 rs9309473 chr2:73743982 A/G cg20560298 chr2:73613845 ALMS1 -0.43 -10.65 -0.39 1.64e-24 Metabolite levels; BRCA cis rs1843834 0.611 rs1058360 chr2:225449242 A/T cg12698349 chr2:225449008 CUL3 0.61 13.07 0.46 8.9e-35 IgE levels in asthmatics (D.p. specific); BRCA cis rs9361491 0.543 rs1507153 chr6:79484386 C/A cg09184832 chr6:79620586 NA -0.4 -7.96 -0.3 7.86e-15 Intelligence (multi-trait analysis); BRCA cis rs10851411 0.697 rs17766258 chr15:42785137 A/G cg21293051 chr15:42870591 STARD9 -0.53 -8.71 -0.33 2.68e-17 Glucose homeostasis traits; BRCA cis rs701145 0.537 rs1713855 chr3:153847833 T/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs4665809 0.590 rs1122972 chr2:26418788 A/C cg26314531 chr2:26401878 FAM59B -0.9 -15.64 -0.53 6.69e-47 Gut microbiome composition (summer); BRCA cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg14664628 chr15:75095509 CSK -0.74 -18.05 -0.58 3.45e-59 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs10924970 1.000 rs10924870 chr1:235359782 C/T cg26050004 chr1:235667680 B3GALNT2 -0.34 -8.43 -0.32 2.22e-16 Asthma; BRCA cis rs7786808 0.741 rs11769149 chr7:158227127 A/G cg01191920 chr7:158217561 PTPRN2 0.46 11.02 0.4 5.44e-26 Obesity-related traits; BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg23978390 chr7:1156363 C7orf50 0.4 8.13 0.31 2.16e-15 Bronchopulmonary dysplasia; BRCA cis rs34172651 0.517 rs36113933 chr16:24838862 A/G cg06028605 chr16:24865363 SLC5A11 0.43 9.63 0.36 1.34e-20 Intelligence (multi-trait analysis); BRCA cis rs9560113 0.959 rs9555802 chr13:112179504 T/C cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 8.85e-19 Bipolar disorder; BRCA cis rs9325144 0.555 rs6582576 chr12:38701230 C/T cg13010199 chr12:38710504 ALG10B -0.34 -8.0 -0.3 5.67e-15 Morning vs. evening chronotype; BRCA cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6743226 0.934 rs6704615 chr2:242228733 A/G cg10021735 chr2:242295487 FARP2 -0.36 -9.91 -0.37 1.24e-21 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg05535760 chr7:792225 HEATR2 0.71 13.37 0.47 4.01e-36 Cerebrospinal P-tau181p levels; BRCA cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs7917772 0.582 rs7907417 chr10:104370662 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.97 -0.48 6.96e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10782582 0.609 rs5745485 chr1:76349534 C/G cg03433033 chr1:76189801 ACADM -0.4 -8.17 -0.31 1.68e-15 Daytime sleep phenotypes; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg13047869 chr3:10149882 C3orf24 0.59 12.11 0.43 1.62e-30 Alzheimer's disease; BRCA trans rs208520 0.586 rs208442 chr6:66900618 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.59 -11.28 -0.41 5.03e-27 Exhaled nitric oxide output; BRCA cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg17691542 chr6:26056736 HIST1H1C 0.98 19.58 0.61 3.18e-67 Iron status biomarkers; BRCA cis rs7617773 0.817 rs3731555 chr3:48206102 G/A cg11946769 chr3:48343235 NME6 0.67 14.0 0.48 4.67e-39 Coronary artery disease; BRCA trans rs561341 1.000 rs498391 chr17:30328704 G/A cg20587970 chr11:113659929 NA -1.21 -21.96 -0.66 4.49e-80 Hip circumference adjusted for BMI; BRCA cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg26818010 chr10:134567672 INPP5A -0.72 -15.21 -0.52 7.79e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg08859206 chr1:53392774 SCP2 -0.41 -8.64 -0.32 4.41e-17 Monocyte count; BRCA cis rs897984 0.542 rs7199949 chr16:31096164 G/C cg02466173 chr16:30829666 NA -0.44 -9.79 -0.36 3.39e-21 Dementia with Lewy bodies; BRCA cis rs10789491 1.000 rs11211342 chr1:47163098 T/C cg15501359 chr1:47185051 KIAA0494 0.65 18.21 0.58 5.39e-60 Response to hepatitis C treatment; BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg00106254 chr7:1943704 MAD1L1 -0.38 -9.33 -0.35 1.76e-19 Bipolar disorder and schizophrenia; BRCA cis rs72772090 0.539 rs72775809 chr5:96183556 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -11.44 -0.41 1.02e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg08807101 chr21:30365312 RNF160 0.74 19.41 0.61 2.47e-66 Dental caries; BRCA cis rs2742234 0.541 rs7096500 chr10:43712095 C/T cg02780029 chr10:43622663 RET 0.35 7.84 0.3 1.89e-14 Hirschsprung disease; BRCA cis rs889312 0.500 rs185219 chr5:56136492 A/G cg24531977 chr5:56204891 C5orf35 -0.41 -8.34 -0.31 4.42e-16 Breast cancer;Breast cancer (early onset); BRCA cis rs914187 0.840 rs914186 chr21:42619657 A/G cg21268422 chr21:42620091 BACE2 -0.55 -11.39 -0.41 1.74e-27 Body mass index; BRCA cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg00290607 chr11:67383545 NA -0.53 -11.49 -0.41 6.85e-28 Mean corpuscular volume; BRCA cis rs9611565 0.694 rs5758368 chr22:41862288 C/T cg03806693 chr22:41940476 POLR3H -0.99 -19.34 -0.61 6.08e-66 Vitiligo; BRCA cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.59 0.35 1.93e-20 Parkinson's disease; BRCA cis rs679087 1.000 rs302321 chr12:29928388 A/C cg14258853 chr12:29935411 TMTC1 0.42 8.99 0.34 2.69e-18 Schizophrenia; BRCA cis rs2033711 0.870 rs6510152 chr19:58953319 C/T cg26874164 chr19:58962979 ZNF324B 0.52 11.16 0.4 1.48e-26 Uric acid clearance; BRCA cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg20607798 chr8:58055168 NA 0.53 8.34 0.31 4.56e-16 Developmental language disorder (linguistic errors); BRCA trans rs629535 0.551 rs62513429 chr8:70149995 A/C cg21567404 chr3:27674614 NA -0.97 -17.72 -0.57 1.98e-57 Dupuytren's disease; BRCA cis rs1005277 0.540 rs289638 chr10:37923731 G/A cg00409905 chr10:38381863 ZNF37A -0.47 -9.72 -0.36 6.42e-21 Extrinsic epigenetic age acceleration; BRCA cis rs6435161 1.000 rs1039968 chr2:203557151 T/C cg18429434 chr2:203499731 FAM117B -0.43 -8.58 -0.32 6.92e-17 Total cholesterol levels; BRCA cis rs13191362 1.000 rs36113695 chr6:163004733 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.1 0.46 6.97e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.32 -0.31 5.51e-16 Aortic root size; BRCA cis rs7246657 0.722 rs2972438 chr19:38210847 A/G cg23950597 chr19:37808831 NA -0.48 -8.22 -0.31 1.17e-15 Coronary artery calcification; BRCA cis rs11577318 0.853 rs4471263 chr1:26622700 C/T cg00852783 chr1:26633632 UBXN11 0.49 10.64 0.39 1.86e-24 Granulocyte percentage of myeloid white cells; BRCA cis rs7927771 0.524 rs1563820 chr11:47833398 A/T cg20307385 chr11:47447363 PSMC3 -0.4 -9.5 -0.35 4.26e-20 Subjective well-being; BRCA cis rs6743226 0.840 rs6747036 chr2:242227054 T/C cg10021735 chr2:242295487 FARP2 0.36 9.96 0.37 8.2e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs1707322 0.721 rs28501477 chr1:46199084 A/G cg03146154 chr1:46216737 IPP 0.53 11.8 0.42 3.42e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12142240 0.698 rs7525309 chr1:46809025 G/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs3784262 0.565 rs4646607 chr15:58285388 A/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.31 -0.35 2.06e-19 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6750047 0.605 rs59501228 chr2:38261972 A/C cg07380506 chr2:38303506 CYP1B1 -0.49 -10.63 -0.39 2.1e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg09184832 chr6:79620586 NA -0.5 -11.16 -0.4 1.48e-26 Intelligence (multi-trait analysis); BRCA cis rs60012524 1 rs60012524 chr2:99559117 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -15.59 -0.52 1.17e-46 Chronic sinus infection; BRCA trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21659725 chr3:3221576 CRBN 0.71 22.21 0.66 2.04e-81 Intelligence (multi-trait analysis); BRCA cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 19.47 0.61 1.19e-66 Smoking behavior; BRCA cis rs9921222 0.585 rs7195617 chr16:376781 A/G cg12437481 chr16:420112 MRPL28 0.48 11.32 0.41 3.48e-27 Bone mineral density (spine);Bone mineral density; BRCA cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.32 -0.44 1.93e-31 Bipolar disorder; BRCA cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg26031613 chr14:104095156 KLC1 -0.43 -8.52 -0.32 1.12e-16 Schizophrenia; BRCA cis rs4478858 0.602 rs6425723 chr1:31715204 T/C cg00250761 chr1:31883323 NA -0.31 -8.07 -0.3 3.51e-15 Alcohol dependence; BRCA cis rs4689388 0.581 rs1801212 chr4:6302519 C/T cg00701064 chr4:6280414 WFS1 0.63 12.17 0.43 8.81e-31 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg01877450 chr7:97915802 BRI3 -0.39 -8.99 -0.33 2.83e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs12291225 0.679 rs34238445 chr11:14315915 C/T cg19336497 chr11:14380999 RRAS2 -0.48 -11.83 -0.42 2.47e-29 Sense of smell; BRCA cis rs6834538 1.000 rs6816676 chr4:113483843 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.39 8.91 0.33 5.09e-18 Free thyroxine concentration; BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg08470875 chr2:26401718 FAM59B -0.71 -11.53 -0.41 4.62e-28 Gut microbiome composition (summer); BRCA cis rs9394841 0.692 rs9394834 chr6:41806793 G/A cg08135965 chr6:41755394 TOMM6 0.47 7.82 0.3 2.15e-14 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs7258465 1.000 rs8105994 chr19:18593553 A/G cg01065977 chr19:18549689 ISYNA1 -0.26 -7.83 -0.3 1.99e-14 Breast cancer; BRCA cis rs311392 0.902 rs411839 chr8:55092189 T/C cg11783602 chr8:55087084 NA -0.32 -9.11 -0.34 1.03e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs7267979 0.899 rs2179459 chr20:25456141 C/A cg08601574 chr20:25228251 PYGB 0.36 8.4 0.32 2.89e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg10802521 chr3:52805072 NEK4 -0.33 -8.48 -0.32 1.61e-16 Bipolar disorder; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg22907277 chr7:1156413 C7orf50 0.57 11.5 0.41 5.9e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6570726 0.935 rs429306 chr6:145827016 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs1348850 0.561 rs4893956 chr2:178373452 C/T cg27490568 chr2:178487706 NA 0.5 8.4 0.32 2.91e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs34779708 0.702 rs4244995 chr10:35547175 A/G cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9462027 0.628 rs6921363 chr6:34770820 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 2.04e-14 Systemic lupus erythematosus; BRCA cis rs4805272 0.512 rs12373558 chr19:29337692 A/G cg12756686 chr19:29218302 NA 0.46 8.07 0.3 3.39e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA trans rs11039798 0.588 rs1814768 chr11:48987455 T/C cg15704280 chr7:45808275 SEPT13 0.58 9.84 0.36 2.29e-21 Axial length; BRCA cis rs523522 0.962 rs2168319 chr12:120933217 C/T cg27279351 chr12:120934652 DYNLL1 0.51 12.4 0.44 8.27e-32 High light scatter reticulocyte count; BRCA cis rs4662945 0.525 rs28625431 chr2:130303333 A/G cg05962382 chr2:130345044 NA -0.33 -8.0 -0.3 5.74e-15 Response to cytidine analogues (gemcitabine); BRCA cis rs8180040 1.000 rs1076394 chr3:47322781 G/A cg27129171 chr3:47204927 SETD2 -0.7 -16.87 -0.56 4.27e-53 Colorectal cancer; BRCA cis rs17376456 0.877 rs10044066 chr5:93437580 T/C cg25358565 chr5:93447407 FAM172A 1.16 19.49 0.61 9.49e-67 Diabetic retinopathy; BRCA cis rs1878931 0.582 rs9921152 chr16:3421199 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.5 8.75 0.33 1.89e-17 Body mass index (adult); BRCA cis rs7246657 0.722 rs10406379 chr19:38036725 G/A cg23950597 chr19:37808831 NA -0.51 -8.65 -0.32 4.11e-17 Coronary artery calcification; BRCA cis rs61990749 0.686 rs11159288 chr14:78216972 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.64 10.04 0.37 3.96e-22 Fibroblast growth factor basic levels; BRCA cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg09417038 chr21:47716443 C21orf57 -0.33 -8.25 -0.31 8.72e-16 Testicular germ cell tumor; BRCA cis rs7927771 0.507 rs11039432 chr11:47873327 G/A cg20307385 chr11:47447363 PSMC3 0.42 9.47 0.35 5.25e-20 Subjective well-being; BRCA cis rs1401999 0.898 rs4148561 chr3:183726379 A/G cg01324343 chr3:183735012 ABCC5 0.83 20.87 0.64 3.74e-74 Anterior chamber depth; BRCA cis rs877282 0.945 rs34367686 chr10:791868 G/C cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs4363385 0.747 rs4314835 chr1:152984901 C/T cg24667326 chr1:152973720 SPRR3 -0.36 -10.03 -0.37 4.19e-22 Inflammatory skin disease; BRCA cis rs8062405 0.964 rs78613234 chr16:28839425 T/C cg09754948 chr16:28834200 ATXN2L 0.46 9.19 0.34 5.45e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11997175 0.766 rs4442096 chr8:33691039 T/C ch.8.33884649F chr8:33765107 NA 0.35 8.19 0.31 1.39e-15 Body mass index; BRCA cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg26597838 chr10:835615 NA 1.03 17.3 0.56 2.73e-55 Eosinophil percentage of granulocytes; BRCA trans rs4957048 0.577 rs56294732 chr5:568144 T/C cg25482853 chr8:67687455 SGK3 0.79 13.97 0.48 7.1e-39 Ulcerative colitis; BRCA cis rs1030877 1.000 rs2576743 chr2:105901337 C/T cg02079111 chr2:105885981 TGFBRAP1 0.72 17.89 0.58 2.49e-58 Obesity-related traits; BRCA cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg08847533 chr14:75593920 NEK9 -0.8 -19.76 -0.62 3.6e-68 Height; BRCA cis rs12142240 0.698 rs56063031 chr1:46825433 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 12.74 0.45 2.73e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg06671706 chr8:8559999 CLDN23 0.45 8.77 0.33 1.57e-17 Obesity-related traits; BRCA cis rs6840360 0.571 rs28454076 chr4:152520083 G/T cg22705602 chr4:152727874 NA -0.32 -8.3 -0.31 6.2e-16 Intelligence (multi-trait analysis); BRCA trans rs4714291 0.855 rs1743971 chr6:40095927 A/C cg02267698 chr19:7991119 CTXN1 0.42 8.13 0.31 2.22e-15 Strep throat; BRCA cis rs10751667 0.643 rs7479473 chr11:929111 C/T cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA cis rs9487051 0.698 rs11153168 chr6:109629420 A/T cg01475377 chr6:109611718 NA -0.45 -10.24 -0.38 6.74e-23 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.0 -0.34 2.61e-18 Developmental language disorder (linguistic errors); BRCA cis rs16958440 0.867 rs2117373 chr18:44671834 C/T cg17192377 chr18:44677553 HDHD2 0.88 13.01 0.46 1.74e-34 Sitting height ratio; BRCA cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg21770322 chr7:97807741 LMTK2 0.41 10.86 0.39 2.39e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg09184832 chr6:79620586 NA -0.53 -11.65 -0.42 1.43e-28 Intelligence (multi-trait analysis); BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg21782813 chr7:2030301 MAD1L1 0.33 9.08 0.34 1.3e-18 Schizophrenia; BRCA cis rs9739070 1 rs9739070 chr12:123771032 A/G cg00376283 chr12:123451042 ABCB9 0.49 10.91 0.4 1.52e-25 Allergy; BRCA cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs9814567 0.964 rs3856729 chr3:134200925 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.26e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9359856 0.564 rs56281344 chr6:90445393 T/C cg13799429 chr6:90582589 CASP8AP2 -0.71 -8.58 -0.32 7.04e-17 Bipolar disorder; BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg21143896 chr7:2802374 GNA12 -0.36 -8.99 -0.33 2.87e-18 Height; BRCA cis rs67460515 0.529 rs6795586 chr3:160897701 A/C cg03342759 chr3:160939853 NMD3 -0.5 -10.14 -0.37 1.73e-22 Parkinson's disease; BRCA cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg18964960 chr10:1102726 WDR37 0.63 8.71 0.33 2.65e-17 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.68 0.39 1.28e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7737355 1.000 rs27873 chr5:130731151 T/C cg06307176 chr5:131281290 NA -0.44 -9.33 -0.35 1.69e-19 Life satisfaction; BRCA cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.86 -0.3 1.59e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg06671706 chr8:8559999 CLDN23 0.44 8.46 0.32 1.88e-16 Obesity-related traits; BRCA cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg26031613 chr14:104095156 KLC1 -0.42 -8.39 -0.32 3.01e-16 Schizophrenia; BRCA cis rs10883723 0.810 rs7093028 chr10:104259417 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1975991 0.686 rs6777135 chr3:187947668 G/A cg15417654 chr3:187959138 LPP 0.36 9.2 0.34 4.86e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs12586317 0.620 rs2295104 chr14:35579927 A/G cg05294307 chr14:35346193 BAZ1A 0.59 10.59 0.39 2.86e-24 Psoriasis; BRCA cis rs9325144 0.505 rs826893 chr12:39100536 A/G cg13010199 chr12:38710504 ALG10B -0.42 -9.71 -0.36 6.68e-21 Morning vs. evening chronotype; BRCA cis rs11758351 0.660 rs113205297 chr6:26210808 A/C cg01420254 chr6:26195488 NA 0.52 8.29 0.31 6.57e-16 Gout;Renal underexcretion gout; BRCA cis rs1865760 0.602 rs2157050 chr6:26020431 C/T cg16482183 chr6:26056742 HIST1H1C 0.52 11.13 0.4 1.99e-26 Height; BRCA cis rs9290065 0.538 rs9840600 chr3:160769101 G/A cg03342759 chr3:160939853 NMD3 -0.55 -11.3 -0.41 4.08e-27 Kawasaki disease; BRCA trans rs61931739 0.500 rs7295779 chr12:34460652 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.1 0.34 1.09e-18 Morning vs. evening chronotype; BRCA cis rs6912958 0.781 rs2273129 chr6:88182439 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.37 -0.31 3.65e-16 Monocyte percentage of white cells; BRCA trans rs2262909 0.889 rs61268244 chr19:22310130 C/T cg17074339 chr11:11642133 GALNTL4 0.45 8.89 0.33 6.28e-18 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg08132940 chr7:1081526 C7orf50 -0.6 -8.99 -0.34 2.69e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7020830 1.000 rs7020830 chr9:37085184 A/T cg14294708 chr9:37120828 ZCCHC7 1.09 33.86 0.8 1.04e-144 Schizophrenia; BRCA trans rs783540 0.967 rs55972423 chr15:83258954 C/G cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.36 -0.31 3.85e-16 Schizophrenia; BRCA cis rs7100689 0.753 rs1361458 chr10:82090339 A/T cg01528321 chr10:82214614 TSPAN14 0.91 20.04 0.62 1.1e-69 Post bronchodilator FEV1; BRCA cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg13010199 chr12:38710504 ALG10B 0.42 8.74 0.33 2.02e-17 Bladder cancer; BRCA cis rs11112613 0.713 rs12321309 chr12:105943263 T/G cg03607813 chr12:105948248 NA 0.6 10.01 0.37 5e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -11.94 -0.43 7.99e-30 Gut microbiome composition (summer); BRCA cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.92 0.4 1.39e-25 Cognitive ability; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg03188948 chr7:1209495 NA 0.63 12.91 0.45 4.99e-34 Longevity;Endometriosis; BRCA cis rs1568889 0.938 rs11601602 chr11:28233768 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 13.29 0.47 8.77e-36 Bipolar disorder; BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg22764044 chr5:178986830 RUFY1 0.51 14.1 0.49 1.75e-39 Lung cancer; BRCA cis rs2290159 0.800 rs6766666 chr3:12690855 A/C cg23032965 chr3:12705835 RAF1 -0.51 -9.05 -0.34 1.72e-18 Cholesterol, total; BRCA cis rs72634258 0.554 rs4908694 chr1:7850898 C/T cg26816564 chr1:7831052 VAMP3 0.69 12.73 0.45 3.12e-33 Inflammatory bowel disease; BRCA cis rs9287719 0.967 rs759403 chr2:10729897 C/T cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.03e-23 Prostate cancer; BRCA cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg19748678 chr4:122722346 EXOSC9 0.72 15.43 0.52 7.08e-46 Type 2 diabetes; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.81 0.36 3e-21 Gut microbiome composition (summer); BRCA cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg13271783 chr10:134563150 INPP5A -0.5 -9.36 -0.35 1.28e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg17294928 chr15:75287854 SCAMP5 -0.64 -13.96 -0.48 7.87e-39 Blood trace element (Zn levels); BRCA cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.92 -0.33 5.05e-18 Alzheimer's disease (late onset); BRCA cis rs10911363 0.615 rs9286848 chr1:183426249 C/G cg09173681 chr1:183549694 NCF2 -0.53 -11.04 -0.4 4.78e-26 Systemic lupus erythematosus; BRCA cis rs17401966 1.000 rs12132635 chr1:10430479 G/A cg15208524 chr1:10270712 KIF1B 0.38 7.86 0.3 1.68e-14 Hepatocellular carcinoma; BRCA cis rs6964587 0.773 rs59242586 chr7:91918145 A/G cg01689657 chr7:91764605 CYP51A1 0.25 8.58 0.32 6.97e-17 Breast cancer; BRCA cis rs4363385 0.747 rs4845330 chr1:152981505 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.15e-18 Inflammatory skin disease; BRCA cis rs12711979 0.509 rs10178286 chr2:3823821 A/G cg17052675 chr2:3827356 NA 0.69 22.71 0.67 3.67e-84 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs9527 0.590 rs10883836 chr10:104891198 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs3008870 0.959 rs2985808 chr1:67367741 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.96 21.03 0.64 5.43e-75 Lymphocyte percentage of white cells; BRCA cis rs9790314 1.000 rs62279921 chr3:161065441 T/C cg04691961 chr3:161091175 C3orf57 -0.62 -15.42 -0.52 7.54e-46 Morning vs. evening chronotype; BRCA cis rs7523273 0.626 rs2466572 chr1:207934487 A/C cg22525895 chr1:207977042 MIR29B2 0.4 8.44 0.32 2.19e-16 Schizophrenia; BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg25036284 chr2:26402008 FAM59B -0.63 -10.68 -0.39 1.29e-24 Gut microbiome composition (summer); BRCA cis rs10207060 0.778 rs6543581 chr2:240702308 C/T cg07506560 chr2:240697449 NA -0.38 -7.98 -0.3 6.78e-15 Obesity-related traits; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg07343612 chr16:622815 PIGQ -0.69 -23.48 -0.68 2.32e-88 Height; BRCA cis rs2243480 1.000 rs35396113 chr7:65495461 C/T cg18252515 chr7:66147081 NA -0.9 -12.9 -0.45 5.17e-34 Diabetic kidney disease; BRCA cis rs524281 0.861 rs10791858 chr11:65978396 A/G cg16950941 chr11:66035639 RAB1B -0.38 -8.11 -0.31 2.58e-15 Electroencephalogram traits; BRCA cis rs875971 0.660 rs801192 chr7:66031952 C/G cg18876405 chr7:65276391 NA -0.62 -15.43 -0.52 6.52e-46 Aortic root size; BRCA cis rs2880765 0.835 rs730372 chr15:86038193 G/T cg10818794 chr15:86012489 AKAP13 0.31 8.56 0.32 8.67e-17 Coronary artery disease; BRCA trans rs116095464 0.558 rs56081398 chr5:247318 C/T cg00938859 chr5:1591904 SDHAP3 0.66 9.06 0.34 1.58e-18 Breast cancer; BRCA cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg11366901 chr6:160182831 ACAT2 -0.72 -14.37 -0.49 9.34e-41 Age-related macular degeneration (geographic atrophy); BRCA cis rs6028335 0.674 rs12625983 chr20:37603936 C/T cg16355469 chr20:37678765 NA -0.48 -8.77 -0.33 1.55e-17 Alcohol and nicotine co-dependence; BRCA cis rs78707713 0.531 rs12411720 chr10:71192471 T/G cg12610070 chr10:71211762 TSPAN15 -0.32 -10.99 -0.4 7.26e-26 Venous thromboembolism; BRCA cis rs7100689 0.646 rs7894762 chr10:82086779 C/G cg00277334 chr10:82204260 NA -0.43 -8.48 -0.32 1.53e-16 Post bronchodilator FEV1; BRCA cis rs2415984 0.622 rs1761029 chr14:46934764 T/C cg14871534 chr14:47121158 RPL10L 0.32 7.94 0.3 9.45e-15 Number of children ever born; BRCA cis rs4671400 0.516 rs62152277 chr2:61503404 C/T cg15711740 chr2:61764176 XPO1 0.44 8.8 0.33 1.28e-17 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs796364 0.539 rs6738494 chr2:200697058 A/C cg23649088 chr2:200775458 C2orf69 0.55 7.98 0.3 6.93e-15 Schizophrenia; BRCA cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.41 8.43 0.32 2.35e-16 Alzheimer's disease (late onset); BRCA cis rs939658 0.728 rs12904323 chr15:79412583 A/C cg17916960 chr15:79447300 NA -0.42 -9.81 -0.36 2.9e-21 Refractive error; BRCA cis rs12541635 0.966 rs7819043 chr8:106989783 T/C cg10147462 chr8:107024639 NA 0.37 9.94 0.37 9.35e-22 Age of smoking initiation; BRCA cis rs9287719 0.967 rs9287720 chr2:10752664 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg04553112 chr3:125709451 NA -0.56 -8.53 -0.32 1.02e-16 Blood pressure (smoking interaction); BRCA cis rs832540 0.618 rs2548663 chr5:56172778 G/A cg12311346 chr5:56204834 C5orf35 -0.49 -10.11 -0.37 2.12e-22 Coronary artery disease; BRCA cis rs6064559 0.685 rs1042523 chr20:56137807 A/G cg16101800 chr20:56136569 PCK1 -0.48 -12.56 -0.44 1.71e-32 Hemoglobin concentration; BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg12379764 chr21:47803548 PCNT 0.37 7.94 0.3 9.18e-15 Testicular germ cell tumor; BRCA cis rs2191566 0.576 rs405763 chr19:44493547 A/G cg20607764 chr19:44506953 ZNF230 0.36 7.87 0.3 1.5e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs2637266 1.000 rs2130795 chr10:78333892 C/G cg18941641 chr10:78392320 NA 0.34 7.83 0.3 2.04e-14 Pulmonary function; BRCA cis rs1577917 0.518 rs6454482 chr6:86418188 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 12.35 0.44 1.37e-31 Response to antipsychotic treatment; BRCA cis rs708547 0.914 rs2412760 chr4:57735192 A/T cg16868167 chr4:57843880 C4orf14;POLR2B -0.49 -11.03 -0.4 4.92e-26 Response to bleomycin (chromatid breaks); BRCA cis rs12291225 0.679 rs10832240 chr11:14304744 C/T cg19336497 chr11:14380999 RRAS2 -0.48 -11.95 -0.43 7.75e-30 Sense of smell; BRCA cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6088580 0.524 rs6142210 chr20:33223012 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.81 -0.33 1.2e-17 Glomerular filtration rate (creatinine); BRCA cis rs9914988 0.832 rs4795462 chr17:27130991 C/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg24549020 chr5:56110836 MAP3K1 0.42 8.95 0.33 3.92e-18 Initial pursuit acceleration; BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg20203395 chr5:56204925 C5orf35 -0.51 -10.4 -0.38 1.64e-23 Initial pursuit acceleration; BRCA cis rs2050392 0.544 rs598672 chr10:30742388 C/T cg18806716 chr10:30721971 MAP3K8 -0.46 -10.81 -0.39 4.01e-25 Inflammatory bowel disease; BRCA cis rs2180341 1.000 rs6569477 chr6:127589302 T/A cg24812749 chr6:127587940 RNF146 0.87 19.8 0.62 2.14e-68 Breast cancer; BRCA cis rs1018836 0.923 rs13262354 chr8:91635731 G/A cg16814680 chr8:91681699 NA -0.58 -12.37 -0.44 1.21e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs17376456 0.825 rs17314762 chr5:93231200 C/T cg25358565 chr5:93447407 FAM172A 1.21 17.99 0.58 7.17e-59 Diabetic retinopathy; BRCA cis rs2153535 0.580 rs6937186 chr6:8494493 A/C cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg15704280 chr7:45808275 SEPT13 0.75 15.99 0.53 1.23e-48 Coronary artery disease; BRCA cis rs6459788 0.720 rs11974772 chr7:157250645 G/A cg03453431 chr7:157225567 NA -0.48 -9.78 -0.36 3.87e-21 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs875971 1.000 rs11971949 chr7:65626014 A/G cg12463550 chr7:65579703 CRCP -0.38 -8.29 -0.31 6.75e-16 Aortic root size; BRCA cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.06 -0.34 1.55e-18 Alzheimer's disease (late onset); BRCA cis rs13046373 0.535 rs1961167 chr21:32030310 T/C cg16812893 chr21:31813075 KRTAP15-1 0.38 9.28 0.34 2.53e-19 HDL cholesterol; BRCA cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg00631329 chr6:26305371 NA -0.55 -15.66 -0.53 5.07e-47 Educational attainment; BRCA cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg08807101 chr21:30365312 RNF160 -0.42 -8.91 -0.33 5.43e-18 Pancreatic cancer; BRCA cis rs11971779 0.648 rs59791374 chr7:139116962 C/T cg07862535 chr7:139043722 LUC7L2 0.4 10.61 0.39 2.5300000000000002e-24 Diisocyanate-induced asthma; BRCA cis rs9487051 0.714 rs7755970 chr6:109602359 A/G cg21918786 chr6:109611834 NA -0.44 -11.87 -0.42 1.69e-29 Reticulocyte fraction of red cells; BRCA cis rs9329221 1.000 rs9329221 chr8:10240202 G/T cg21775007 chr8:11205619 TDH 0.38 8.12 0.31 2.44e-15 Neuroticism; BRCA cis rs10504073 0.647 rs4873317 chr8:50021111 C/T cg00325661 chr8:49890786 NA 0.44 12.52 0.44 2.54e-32 Blood metabolite ratios; BRCA cis rs7590720 0.819 rs6435931 chr2:216892754 C/G cg12620499 chr2:216877984 MREG 0.82 24.97 0.7 1.52e-96 Alcohol dependence; BRCA cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs2228479 0.764 rs35518096 chr16:89961140 C/A cg06558623 chr16:89946397 TCF25 0.65 11.86 0.42 1.81e-29 Skin colour saturation; BRCA cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg12310025 chr6:25882481 NA 0.72 17.85 0.58 4.14e-58 Blood metabolite levels; BRCA cis rs921968 0.541 rs7603816 chr2:219396255 C/T cg02176678 chr2:219576539 TTLL4 -0.5 -12.74 -0.45 2.64e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs11718455 1.000 rs9854785 chr3:44031295 A/G cg08738300 chr3:44038990 NA 0.44 8.54 0.32 9.8e-17 Coronary artery disease; BRCA cis rs68170813 0.641 rs79328953 chr7:106901557 C/T cg02696742 chr7:106810147 HBP1 -0.5 -8.86 -0.33 7.78e-18 Coronary artery disease; BRCA cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg08000102 chr2:233561755 GIGYF2 0.64 13.93 0.48 1.03e-38 Coronary artery disease; BRCA cis rs9858542 1.000 rs9812791 chr3:49682311 G/A cg03060546 chr3:49711283 APEH -0.61 -12.3 -0.44 2.28e-31 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs11711311 0.911 rs3773681 chr3:113523901 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.78 -0.36 3.92e-21 IgG glycosylation; BRCA cis rs1401999 1.000 rs6443927 chr3:183718864 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.19 0.37 1.05e-22 Anterior chamber depth; BRCA cis rs3091242 0.933 rs4649084 chr1:25752617 A/G cg02931644 chr1:25747376 RHCE 0.43 11.66 0.42 1.23e-28 Erythrocyte sedimentation rate; BRCA cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg08213375 chr14:104286397 PPP1R13B 0.64 18.2 0.58 5.6899999999999994e-60 Schizophrenia; BRCA cis rs5167 0.504 rs3760629 chr19:45458146 A/C cg13119609 chr19:45449297 APOC2 0.46 12.71 0.45 3.79e-33 Blood protein levels; BRCA cis rs12887734 0.524 rs12588797 chr14:104300020 C/T cg08213375 chr14:104286397 PPP1R13B -0.5 -11.33 -0.41 3.11e-27 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.534 rs1352207 chr12:34036862 C/T cg26384229 chr12:38710491 ALG10B -0.49 -10.75 -0.39 6.63e-25 Morning vs. evening chronotype; BRCA cis rs7726839 0.561 rs3915384 chr5:573395 G/T cg09021430 chr5:549028 NA -0.65 -16.14 -0.54 2e-49 Obesity-related traits; BRCA cis rs1949733 0.675 rs2688219 chr4:8444631 T/C cg11789530 chr4:8429930 ACOX3 0.59 14.62 0.5 5.43e-42 Response to antineoplastic agents; BRCA cis rs62158211 0.955 rs7556815 chr2:114085785 G/A cg17784749 chr2:114082611 LOC440839 0.56 9.54 0.35 2.88e-20 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; BRCA cis rs4730250 0.669 rs6466160 chr7:106793175 T/A cg02696742 chr7:106810147 HBP1 0.57 9.43 0.35 7.51e-20 Osteoarthritis; BRCA cis rs2204008 0.837 rs1589395 chr12:38420405 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.62 0.39 2.17e-24 Bladder cancer; BRCA cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg12373951 chr3:133503437 NA 0.44 10.22 0.37 8.02e-23 Iron status biomarkers; BRCA trans rs8073060 0.586 rs225298 chr17:33923946 T/G cg19694781 chr19:47549865 TMEM160 -1.04 -22.12 -0.66 5.97e-81 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9467711 0.591 rs13192365 chr6:25993968 T/C cg21479132 chr6:26055353 NA 0.57 7.97 0.3 7.48e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6964587 1.000 rs10263309 chr7:91645265 A/G cg17063962 chr7:91808500 NA 0.52 12.38 0.44 1.01e-31 Breast cancer; BRCA cis rs2274471 0.645 rs3780375 chr9:5109431 G/A cg03390472 chr9:5043263 JAK2 -0.46 -8.67 -0.32 3.54e-17 Crohn's disease; BRCA cis rs6430585 0.583 rs2304370 chr2:136561735 G/A cg07169764 chr2:136633963 MCM6 1.01 22.6 0.67 1.49e-83 Corneal structure; BRCA trans rs7615952 0.688 rs12485622 chr3:125710739 T/C cg07211511 chr3:129823064 LOC729375 -0.62 -11.18 -0.4 1.21e-26 Blood pressure (smoking interaction); BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.55 10.31 0.38 3.74e-23 Alzheimer's disease; BRCA cis rs7149337 0.773 rs3007067 chr14:51596420 G/A cg23942311 chr14:51606299 NA 0.45 12.86 0.45 8.31e-34 Cancer; BRCA cis rs6912958 0.684 rs4707382 chr6:88320641 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.38 -0.31 3.41e-16 Monocyte percentage of white cells; BRCA cis rs1595825 0.891 rs59617443 chr2:198653204 C/A cg19156104 chr2:198669113 PLCL1 -0.42 -7.97 -0.3 7.13e-15 Ulcerative colitis; BRCA cis rs2425143 1.000 rs113203744 chr20:34253656 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.8 -0.33 1.31e-17 Blood protein levels; BRCA cis rs2180341 1.000 rs6569480 chr6:127621748 A/G cg24812749 chr6:127587940 RNF146 0.9 20.92 0.64 2.01e-74 Breast cancer; BRCA cis rs8062405 1.000 rs62036617 chr16:28827498 T/C cg09754948 chr16:28834200 ATXN2L 0.46 9.16 0.34 7.18e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs2797160 1.000 rs2747725 chr6:126012397 A/C cg05039488 chr6:79577232 IRAK1BP1 0.36 8.03 0.3 4.65e-15 Endometrial cancer; BRCA cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg11742103 chr11:62369870 EML3;MTA2 0.49 12.39 0.44 9.06e-32 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs812925 0.537 rs778146 chr2:61606475 A/G cg15711740 chr2:61764176 XPO1 0.32 7.9 0.3 1.22e-14 Immature fraction of reticulocytes; BRCA cis rs9640161 0.830 rs6722 chr7:150068933 T/C cg21361702 chr7:150065534 REPIN1 0.49 10.07 0.37 3.03e-22 Blood protein levels;Circulating chemerin levels; BRCA cis rs11718455 0.960 rs1852036 chr3:44003862 C/T cg08738300 chr3:44038990 NA 0.45 8.65 0.32 4.03e-17 Coronary artery disease; BRCA cis rs11030122 0.632 rs11030599 chr11:4031677 A/G cg18678763 chr11:4115507 RRM1 -0.35 -8.24 -0.31 9.61e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs1997103 1.000 rs4590393 chr7:55408990 C/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7818345 0.967 rs4921638 chr8:19274793 C/A cg11303988 chr8:19266685 CSGALNACT1 0.3 7.84 0.3 1.91e-14 Language performance in older adults (adjusted for episodic memory); BRCA cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg25319279 chr11:5960081 NA -0.43 -8.4 -0.32 3e-16 DNA methylation (variation); BRCA cis rs7572733 0.534 rs700683 chr2:198712332 G/A cg00792783 chr2:198669748 PLCL1 0.47 10.11 0.37 2.17e-22 Dermatomyositis; BRCA trans rs61931739 0.500 rs7306435 chr12:34482933 A/G cg26384229 chr12:38710491 ALG10B -0.74 -16.47 -0.55 4.44e-51 Morning vs. evening chronotype; BRCA cis rs6060717 0.536 rs6060664 chr20:34478884 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.08 -0.3 3.21e-15 Hip circumference adjusted for BMI; BRCA cis rs17270561 0.609 rs4712960 chr6:25727265 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs4481887 0.927 rs11204637 chr1:248492581 G/A cg00666640 chr1:248458726 OR2T12 0.33 8.99 0.34 2.75e-18 Common traits (Other); BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.07 0.62 7.34e-70 Platelet count; BRCA cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg17892150 chr10:133769511 PPP2R2D -0.72 -15.56 -0.52 1.63e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg26608667 chr7:1196370 ZFAND2A 0.37 8.3 0.31 6.3e-16 Longevity;Endometriosis; BRCA cis rs6088580 0.601 rs6120668 chr20:33099793 A/G cg08999081 chr20:33150536 PIGU 0.47 13.11 0.46 6.3e-35 Glomerular filtration rate (creatinine); BRCA cis rs589448 0.967 rs634512 chr12:69754012 C/T cg22834771 chr12:69754056 YEATS4 -0.43 -10.63 -0.39 2.04e-24 Cerebrospinal fluid biomarker levels; BRCA trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg03929089 chr4:120376271 NA -0.68 -13.31 -0.47 7.52e-36 Coronary artery disease; BRCA cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg02880119 chr16:3481970 NA 0.44 7.97 0.3 7.41e-15 Body mass index (adult); BRCA cis rs7845219 0.597 rs7002058 chr8:95873993 G/C cg16049864 chr8:95962084 TP53INP1 -0.4 -9.57 -0.35 2.32e-20 Type 2 diabetes; BRCA cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00166722 chr3:10149974 C3orf24 0.56 10.0 0.37 5.5e-22 Alzheimer's disease; BRCA trans rs2797160 0.935 rs12717178 chr6:126016499 G/A cg05039488 chr6:79577232 IRAK1BP1 0.35 7.88 0.3 1.4e-14 Endometrial cancer; BRCA cis rs7666738 0.861 rs28821920 chr4:98962743 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.96 0.56 1.53e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs6598955 0.671 rs12129482 chr1:26623641 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.64 -15.27 -0.52 4.23e-45 Obesity-related traits; BRCA cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.24 -0.34 3.54e-19 Menopause (age at onset); BRCA cis rs7727544 0.684 rs274546 chr5:131699867 A/G cg07395648 chr5:131743802 NA -0.39 -9.66 -0.36 1.04e-20 Blood metabolite levels; BRCA cis rs13095912 0.743 rs13076556 chr3:185339575 A/G cg11274856 chr3:185301563 NA 0.54 12.88 0.45 6.28e-34 Systolic blood pressure; BRCA cis rs4363385 0.720 rs1415967 chr1:152965585 C/T cg21543102 chr1:152974771 SPRR3 -0.3 -8.62 -0.32 5.38e-17 Inflammatory skin disease; BRCA cis rs10504229 0.679 rs11783963 chr8:58130496 T/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs3845702 1.000 rs10497555 chr2:180864967 A/G cg01881094 chr2:180872142 CWC22 0.63 12.47 0.44 4.15e-32 Schizophrenia; BRCA cis rs4730250 0.554 rs112665932 chr7:106916121 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.05 -0.3 4.17e-15 Osteoarthritis; BRCA cis rs7020830 0.894 rs12337316 chr9:37148105 G/A cg14294708 chr9:37120828 ZCCHC7 1.05 31.27 0.78 6.68e-131 Schizophrenia; BRCA cis rs853679 0.517 rs9380055 chr6:28081629 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA cis rs13046373 0.507 rs2832969 chr21:32019627 A/G cg16431978 chr21:31797932 KRTAP13-3 0.36 9.13 0.34 8.98e-19 HDL cholesterol; BRCA cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg08917208 chr2:24149416 ATAD2B 0.93 13.73 0.48 9.11e-38 Lymphocyte counts; BRCA cis rs4730250 0.707 rs257386 chr7:106807783 C/G cg02696742 chr7:106810147 HBP1 -0.61 -9.6 -0.36 1.75e-20 Osteoarthritis; BRCA trans rs3942852 0.774 rs924715 chr11:48181060 G/A cg03929089 chr4:120376271 NA -0.49 -9.11 -0.34 1.04e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg14926445 chr8:58193284 C8orf71 -0.44 -8.41 -0.32 2.59e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.875 rs2748490 chr6:146329681 G/T cg23711669 chr6:146136114 FBXO30 0.64 14.63 0.5 4.89e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -12.84 -0.45 1.02e-33 Mood instability; BRCA cis rs9325144 0.505 rs7138977 chr12:38642109 G/A cg13010199 chr12:38710504 ALG10B 0.39 8.94 0.33 4.09e-18 Morning vs. evening chronotype; BRCA cis rs77972916 0.611 rs10495899 chr2:43602304 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -10.84 -0.39 2.9e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg08493051 chr2:3487164 NA -0.43 -9.22 -0.34 4.1e-19 Neurofibrillary tangles; BRCA cis rs10752881 1.000 rs4454510 chr1:182982303 A/G ch.1.3577855R chr1:183094577 LAMC1 -0.63 -16.96 -0.56 1.57e-53 Colorectal cancer; BRCA cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs4974559 0.690 rs28641665 chr4:1288781 G/T cg02980000 chr4:1222292 CTBP1 0.81 13.37 0.47 3.94e-36 Systolic blood pressure; BRCA cis rs7927771 0.965 rs35985502 chr11:47847428 G/A cg18512352 chr11:47633146 NA -0.34 -8.32 -0.31 5.4e-16 Subjective well-being; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.12 -0.34 9.78e-19 Total body bone mineral density; BRCA trans rs9784649 0.891 rs57762467 chr5:25025700 C/T cg08600765 chr20:34638493 LOC647979 -0.53 -7.91 -0.3 1.1e-14 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7617773 0.780 rs34749846 chr3:48347168 T/G cg11946769 chr3:48343235 NME6 0.68 13.86 0.48 2.24e-38 Coronary artery disease; BRCA cis rs10883723 0.810 rs6584504 chr10:104253507 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs950776 0.648 rs57945453 chr15:78862845 C/T cg06917634 chr15:78832804 PSMA4 0.66 13.76 0.48 6.64e-38 Sudden cardiac arrest; BRCA cis rs7927592 0.956 rs948315 chr11:68309140 T/C cg20283391 chr11:68216788 NA -0.44 -8.96 -0.33 3.47e-18 Total body bone mineral density; BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg27170947 chr2:26402098 FAM59B -0.66 -11.41 -0.41 1.4e-27 Gut microbiome composition (summer); BRCA trans rs1493916 0.777 rs1845385 chr18:31318336 T/C cg27147174 chr7:100797783 AP1S1 -0.41 -8.04 -0.3 4.47e-15 Life satisfaction; BRCA cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.43 0.35 7.76e-20 Tonsillectomy; BRCA cis rs12497850 0.931 rs7623023 chr3:48914238 G/A cg06212747 chr3:49208901 KLHDC8B 0.49 10.29 0.38 4.3e-23 Parkinson's disease; BRCA cis rs7666738 0.800 rs1559858 chr4:99024075 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 8.9e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7615952 0.599 rs1875683 chr3:125732481 C/G cg05084668 chr3:125655381 ALG1L -0.47 -8.13 -0.31 2.3e-15 Blood pressure (smoking interaction); BRCA cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg02187348 chr16:89574699 SPG7 0.38 9.05 0.34 1.73e-18 Multiple myeloma (IgH translocation); BRCA cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.72e-15 Extrinsic epigenetic age acceleration; BRCA cis rs6701037 1.000 rs6701037 chr1:175120079 G/T cg17845761 chr1:175162550 KIAA0040 0.26 10.08 0.37 2.92e-22 Alcohol dependence; BRCA cis rs11122272 0.735 rs2749716 chr1:231486908 T/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -11.74 -0.42 5.76e-29 Hemoglobin concentration; BRCA cis rs6582630 0.599 rs8175936 chr12:38426315 C/G cg26384229 chr12:38710491 ALG10B -0.43 -10.06 -0.37 3.32e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.61 13.04 0.46 1.24e-34 Lymphocyte counts; BRCA cis rs9818758 0.556 rs13086240 chr3:49001409 G/A cg00383909 chr3:49044727 WDR6 0.98 15.74 0.53 2.1e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs875971 0.545 rs6460281 chr7:65681115 A/C cg11764359 chr7:65958608 NA 0.66 11.84 0.42 2.3e-29 Aortic root size; BRCA cis rs910316 0.737 rs175071 chr14:75498177 A/G cg11812906 chr14:75593930 NEK9 -0.6 -13.7 -0.48 1.18e-37 Height; BRCA cis rs523522 0.962 rs7471 chr12:120941215 T/C cg12219531 chr12:120966889 COQ5 0.54 11.39 0.41 1.72e-27 High light scatter reticulocyte count; BRCA cis rs7607369 0.648 rs7582193 chr2:219652532 T/C cg02176678 chr2:219576539 TTLL4 -0.47 -12.65 -0.45 7.19e-33 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs17253792 0.822 rs76164147 chr14:56140369 T/C cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg21918786 chr6:109611834 NA 0.46 13.29 0.47 9.25e-36 Reticulocyte fraction of red cells; BRCA cis rs7927771 0.864 rs10838724 chr11:47527052 G/T cg18512352 chr11:47633146 NA -0.34 -8.11 -0.31 2.52e-15 Subjective well-being; BRCA trans rs7829975 0.688 rs6995407 chr8:8384647 C/G cg21775007 chr8:11205619 TDH 0.41 8.58 0.32 7.06e-17 Mood instability; BRCA cis rs7647973 0.626 rs11130217 chr3:49737323 A/G cg07636037 chr3:49044803 WDR6 0.5 8.25 0.31 9.35e-16 Menarche (age at onset); BRCA cis rs72781680 1.000 rs72796388 chr2:24171509 A/C cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg17470723 chr8:74884337 TCEB1 -0.37 -8.17 -0.31 1.65e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg21747090 chr2:27597821 SNX17 -0.44 -9.33 -0.35 1.73e-19 Total body bone mineral density; BRCA trans rs747782 0.528 rs11039669 chr11:48328818 C/T cg15704280 chr7:45808275 SEPT13 0.54 8.19 0.31 1.43e-15 Intraocular pressure; BRCA cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg09184832 chr6:79620586 NA -0.47 -10.37 -0.38 2.19e-23 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg25358565 chr5:93447407 FAM172A 1.22 18.61 0.59 4.26e-62 Diabetic retinopathy; BRCA trans rs3733585 0.660 rs13122290 chr4:9933832 A/G cg26043149 chr18:55253948 FECH -0.41 -9.0 -0.34 2.53e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg26384229 chr12:38710491 ALG10B -0.84 -22.69 -0.67 4.86e-84 Heart rate; BRCA cis rs274567 0.550 rs272885 chr5:131667736 A/G cg09877947 chr5:131593287 PDLIM4 0.36 7.84 0.3 1.94e-14 Blood metabolite levels; BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg26732615 chr19:19648335 CILP2;YJEFN3 -0.37 -8.21 -0.31 1.2e-15 Tonsillectomy; BRCA cis rs60843830 1.000 rs62114548 chr2:274672 C/G cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.38 0.59 6.86e-61 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7903847 0.596 rs10882934 chr10:99170995 T/G cg08345082 chr10:99160200 RRP12 -0.3 -8.62 -0.32 5.25e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg26818010 chr10:134567672 INPP5A -0.78 -15.37 -0.52 1.39e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4148883 0.504 rs2000864 chr4:100123776 A/C cg13256891 chr4:100009986 ADH5 0.39 9.0 0.34 2.66e-18 Alcohol dependence; BRCA cis rs17253792 0.822 rs13379340 chr14:56050346 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.68e-16 Putamen volume; BRCA cis rs1371614 0.569 rs486582 chr2:27104131 C/T cg12368169 chr2:27073192 DPYSL5 0.31 9.58 0.35 2.14e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg00530320 chr1:46809349 NSUN4 0.45 8.97 0.33 3.37e-18 Menopause (age at onset); BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg08061076 chr7:1943177 MAD1L1 -0.35 -7.86 -0.3 1.63e-14 Bipolar disorder and schizophrenia; BRCA cis rs10046574 0.831 rs113826521 chr7:135167999 T/C cg27474649 chr7:135195673 CNOT4 0.61 8.87 0.33 7.2e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.51 -0.35 3.86e-20 Total body bone mineral density; BRCA cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg04166393 chr7:2884313 GNA12 0.43 9.33 0.35 1.72e-19 Height; BRCA cis rs977987 0.806 rs1895490 chr16:75392806 G/A cg03315344 chr16:75512273 CHST6 0.52 12.42 0.44 7.37e-32 Dupuytren's disease; BRCA cis rs9287719 0.967 rs7587231 chr2:10740093 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA trans rs7615952 0.641 rs12495947 chr3:125771698 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -11.03 -0.4 4.99e-26 Blood pressure (smoking interaction); BRCA cis rs4243830 0.737 rs11122085 chr1:6597861 T/C cg22792644 chr1:6614718 TAS1R1;NOL9 0.93 16.85 0.55 5.43e-53 Body mass index; BRCA cis rs78456975 1.000 rs11891809 chr2:1566001 A/G cg01028140 chr2:1542097 TPO -0.72 -14.13 -0.49 1.2e-39 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg04944784 chr2:26401820 FAM59B 1.01 16.65 0.55 5.91e-52 Gut microbiome composition (summer); BRCA trans rs208520 0.690 rs1100981 chr6:66852052 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.35 -0.65 9.92e-77 Exhaled nitric oxide output; BRCA cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.85e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4808199 0.895 rs7252888 chr19:19628037 C/T cg03709012 chr19:19516395 GATAD2A 1.08 21.04 0.64 4.43e-75 Nonalcoholic fatty liver disease; BRCA cis rs6964587 1.000 rs36120033 chr7:91679298 G/A cg01689657 chr7:91764605 CYP51A1 0.21 7.82 0.3 2.14e-14 Breast cancer; BRCA cis rs7666738 0.752 rs35436270 chr4:99088280 G/A cg05340658 chr4:99064831 C4orf37 0.51 9.66 0.36 1.03e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs9486719 1.000 rs10872018 chr6:97026429 G/A cg06623918 chr6:96969491 KIAA0776 -0.77 -13.77 -0.48 5.7800000000000005e-38 Migraine;Coronary artery disease; BRCA cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs757081 0.671 rs214070 chr11:17305317 T/A cg15432903 chr11:17409602 KCNJ11 -0.49 -8.59 -0.32 6.68e-17 Systolic blood pressure; BRCA cis rs7402982 0.934 rs6598539 chr15:99204483 T/C cg03437748 chr15:99193247 IGF1R 0.71 17.33 0.57 1.91e-55 Birth weight; BRCA cis rs9487051 0.646 rs13203365 chr6:109614810 G/T cg01475377 chr6:109611718 NA -0.38 -8.16 -0.31 1.77e-15 Reticulocyte fraction of red cells; BRCA cis rs4363385 0.747 rs1015995 chr1:152976114 G/C cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA cis rs6456156 0.766 rs150112 chr6:167509878 C/T cg07741184 chr6:167504864 NA -0.27 -7.84 -0.3 1.92e-14 Primary biliary cholangitis; BRCA trans rs2727020 0.521 rs11040408 chr11:49534880 A/T cg15704280 chr7:45808275 SEPT13 0.68 13.92 0.48 1.19e-38 Coronary artery disease; BRCA cis rs1843834 0.539 rs6749402 chr2:225443901 T/G cg12698349 chr2:225449008 CUL3 0.61 13.1 0.46 6.76e-35 IgE levels in asthmatics (D.p. specific); BRCA cis rs11098499 0.863 rs58452170 chr4:120459674 A/T cg09307838 chr4:120376055 NA 0.7 14.06 0.49 2.51e-39 Corneal astigmatism; BRCA cis rs9287719 0.649 rs6721857 chr2:10721210 C/T cg00105475 chr2:10696890 NA -0.4 -8.89 -0.33 6.1e-18 Prostate cancer; BRCA cis rs3768617 0.510 rs10797844 chr1:183082067 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 18.01 0.58 5.98e-59 Fuchs's corneal dystrophy; BRCA cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs870825 0.655 rs10033035 chr4:185630880 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.9e-54 Blood protein levels; BRCA cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg14349672 chr11:133703707 NA -0.43 -9.53 -0.35 3.29e-20 Childhood ear infection; BRCA cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg02475777 chr4:1388615 CRIPAK 0.38 8.81 0.33 1.14e-17 Longevity; BRCA cis rs2070997 0.667 rs72765063 chr9:133717391 G/A cg11464064 chr9:133710261 ABL1 0.55 9.92 0.37 1.14e-21 Response to amphetamines; BRCA cis rs9443645 0.527 rs10943596 chr6:79575292 C/T cg09184832 chr6:79620586 NA -0.43 -8.6 -0.32 6.25e-17 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg08917208 chr2:24149416 ATAD2B 1.07 14.55 0.5 1.27e-41 Lymphocyte counts; BRCA cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.46 -9.16 -0.34 7.1e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12458462 0.859 rs2242177 chr18:77477379 G/A cg11879182 chr18:77439856 CTDP1 0.64 13.74 0.48 7.85e-38 Monocyte count; BRCA cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg12140854 chr5:148520817 ABLIM3 -0.42 -8.86 -0.33 7.92e-18 Breast cancer; BRCA cis rs738322 0.935 rs4384 chr22:38572440 G/C cg25457927 chr22:38595422 NA -0.33 -12.52 -0.44 2.53e-32 Cutaneous nevi; BRCA cis rs7493 0.853 rs6973380 chr7:95043523 C/T cg17330251 chr7:94953956 PON1 -0.39 -7.88 -0.3 1.37e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs3733585 0.648 rs28513781 chr4:9959334 G/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9381107 0.932 rs9394703 chr6:9455062 C/T cg14735645 chr6:9486422 NA 0.45 7.95 0.3 8.22e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs6570726 0.526 rs4896805 chr6:145735429 C/A cg23711669 chr6:146136114 FBXO30 -0.45 -9.69 -0.36 8.5e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs6714710 0.603 rs2278700 chr2:98427382 T/C cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.86e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs10193935 1.000 rs13419669 chr2:42387254 T/C cg27598129 chr2:42591480 NA -0.87 -14.49 -0.5 2.46e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs6546550 0.935 rs10865380 chr2:70091246 T/C cg02498382 chr2:70120550 SNRNP27 -0.43 -9.39 -0.35 1.04e-19 Prevalent atrial fibrillation; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg00106254 chr7:1943704 MAD1L1 -0.33 -8.31 -0.31 5.88e-16 Bipolar disorder and schizophrenia; BRCA cis rs9790314 1.000 rs336590 chr3:161079583 G/A cg03342759 chr3:160939853 NMD3 -0.63 -13.45 -0.47 1.75e-36 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs6115159 chr20:25350944 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4302748 0.862 rs61003864 chr7:36189798 T/C cg24442661 chr7:36192818 EEPD1 0.48 9.09 0.34 1.24e-18 Platelet count; BRCA cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 13.44 0.47 1.85e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg11941060 chr3:133502564 NA -0.5 -12.04 -0.43 3.04e-30 Iron status biomarkers; BRCA cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg04166393 chr7:2884313 GNA12 0.41 8.68 0.32 3.35e-17 Height; BRCA trans rs7939886 0.920 rs12417606 chr11:55750479 C/T cg15704280 chr7:45808275 SEPT13 0.62 7.94 0.3 9.08e-15 Myopia (pathological); BRCA trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg15704280 chr7:45808275 SEPT13 -0.93 -26.3 -0.72 7.17e-104 Height; BRCA cis rs9837602 0.938 rs28503408 chr3:99794842 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 10.46 0.38 9.25e-24 Breast cancer; BRCA cis rs6750047 0.546 rs1367696 chr2:38286914 C/T cg07380506 chr2:38303506 CYP1B1 0.47 11.24 0.41 7.39e-27 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7666738 0.791 rs10013680 chr4:99023030 G/C cg05340658 chr4:99064831 C4orf37 0.68 16.78 0.55 1.25e-52 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg25517755 chr10:38738941 LOC399744 -0.39 -8.1 -0.31 2.74e-15 Corneal astigmatism; BRCA cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg06238570 chr21:40685208 BRWD1 -0.43 -8.41 -0.32 2.67e-16 Cognitive function; BRCA cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg27286337 chr10:134555280 INPP5A -0.75 -12.4 -0.44 8.43e-32 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs703842 0.964 rs2014886 chr12:58177437 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.02 0.43 3.79e-30 Multiple sclerosis; BRCA cis rs1043763 0.826 rs3741452 chr12:122628429 A/T cg14400030 chr12:122498111 BCL7A -0.66 -13.64 -0.47 2.24e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs4566357 0.615 rs10174591 chr2:227913140 G/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.08 -0.3 3.32e-15 Coronary artery disease; BRCA cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -9.43 -0.35 7.18e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs6546550 0.933 rs1454498 chr2:70149225 C/A cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.89e-28 Prevalent atrial fibrillation; BRCA cis rs1577917 0.958 rs12215265 chr6:86443969 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.6 -0.45 1.15e-32 Response to antipsychotic treatment; BRCA cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg15145296 chr3:125709740 NA -0.55 -8.81 -0.33 1.13e-17 Blood pressure (smoking interaction); BRCA cis rs9457247 1.000 rs408087 chr6:167398952 C/T cg23791538 chr6:167370224 RNASET2 -0.37 -9.14 -0.34 8.39e-19 Crohn's disease; BRCA cis rs7945705 0.776 rs2316865 chr11:8815470 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.51 10.46 0.38 1e-23 Hemoglobin concentration; BRCA trans rs3733585 0.699 rs62294332 chr4:9959989 T/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs867371 1.000 rs1174543 chr15:82448073 C/T cg00614314 chr15:82944287 LOC80154 -0.43 -9.14 -0.34 8.44e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg24642439 chr20:33292090 TP53INP2 -0.52 -11.23 -0.41 7.97e-27 Glomerular filtration rate (creatinine); BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg03354898 chr7:1950403 MAD1L1 0.44 8.95 0.33 3.74e-18 Bipolar disorder and schizophrenia; BRCA cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg27286337 chr10:134555280 INPP5A 0.8 13.19 0.46 2.56e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs9325144 0.555 rs7968322 chr12:38792348 T/C cg23762105 chr12:34175262 ALG10 0.37 8.57 0.32 7.7e-17 Morning vs. evening chronotype; BRCA trans rs2727020 0.796 rs7131672 chr11:49274421 A/C cg03929089 chr4:120376271 NA 0.65 12.61 0.45 1.01e-32 Coronary artery disease; BRCA cis rs10504073 0.584 rs56074306 chr8:49940282 C/T cg00325661 chr8:49890786 NA 0.49 14.21 0.49 5.09e-40 Blood metabolite ratios; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.62 10.19 0.37 1.03e-22 Renal function-related traits (BUN); BRCA cis rs372883 0.648 rs1153288 chr21:30686091 A/G cg24692254 chr21:30365293 RNF160 0.44 9.94 0.37 9.45e-22 Pancreatic cancer; BRCA cis rs4908760 0.965 rs301814 chr1:8510577 T/C cg20416874 chr1:8611966 RERE -0.28 -8.0 -0.3 5.87e-15 Vitiligo; BRCA cis rs427394 0.582 rs274662 chr5:6704860 G/A cg10857441 chr5:6722123 POLS -0.3 -9.42 -0.35 8.22e-20 Menopause (age at onset); BRCA cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg24812749 chr6:127587940 RNF146 0.67 15.05 0.51 4.9e-44 Breast cancer; BRCA cis rs11945232 1.000 rs6854710 chr4:88334640 A/G cg23841344 chr4:88312519 HSD17B11 -0.48 -9.53 -0.35 3.18e-20 Intelligence (multi-trait analysis); BRCA cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.691 rs2602887 chr4:100041473 A/G cg12011299 chr4:100065546 ADH4 0.46 10.39 0.38 1.85e-23 Alcohol dependence; BRCA trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg17470723 chr8:74884337 TCEB1 0.39 8.51 0.32 1.25e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg11663144 chr21:46675770 NA -0.59 -14.05 -0.49 2.86e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4363385 0.747 rs4845333 chr1:152982877 G/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.15e-18 Inflammatory skin disease; BRCA cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg08885076 chr2:99613938 TSGA10 -0.56 -12.54 -0.44 2.01e-32 Chronic sinus infection; BRCA cis rs10493773 0.748 rs12758511 chr1:86165987 C/T cg17807903 chr1:86174739 ZNHIT6 -0.45 -10.54 -0.38 4.83e-24 Urate levels in overweight individuals; BRCA cis rs6860806 0.507 rs273901 chr5:131694360 G/T cg07395648 chr5:131743802 NA -0.37 -7.95 -0.3 8.72e-15 Breast cancer; BRCA cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg03425785 chr20:62221387 GMEB2 0.51 8.23 0.31 1.07e-15 Glioblastoma; BRCA cis rs2777491 0.915 rs28526381 chr15:41621842 A/C cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.87 -0.48 1.89e-38 Ulcerative colitis; BRCA cis rs6570726 0.818 rs398812 chr6:145817271 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.79e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs2180341 1.000 rs7776136 chr6:127638348 A/T cg27446573 chr6:127587934 RNF146 0.85 19.78 0.62 2.75e-68 Breast cancer; BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA trans rs11577318 1.000 rs11577318 chr1:26601570 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.63 -14.73 -0.5 1.7e-42 Granulocyte percentage of myeloid white cells; BRCA cis rs10411936 0.682 rs6512113 chr19:16598269 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.71 0.36 7.15e-21 White blood cell count;Multiple sclerosis; BRCA cis rs10504229 0.683 rs56204590 chr8:58131642 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs10046574 0.831 rs78220593 chr7:135166787 T/C cg27474649 chr7:135195673 CNOT4 0.61 8.89 0.33 6.04e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -9.72 -0.36 6.27e-21 Schizophrenia; BRCA trans rs12310956 0.510 rs1386936 chr12:33875369 G/A cg26384229 chr12:38710491 ALG10B 0.39 9.22 0.34 4.24e-19 Morning vs. evening chronotype; BRCA cis rs9733 0.569 rs11204691 chr1:150644339 A/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs1552244 0.572 rs17032440 chr3:10169819 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.56 9.1 0.34 1.17e-18 Alzheimer's disease; BRCA cis rs72627509 0.857 rs781658 chr4:57779567 G/A cg26694713 chr4:57773883 REST 0.5 10.03 0.37 4.39e-22 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs67478160 0.575 rs8014294 chr14:104322983 A/G cg01849466 chr14:104193079 ZFYVE21 -0.49 -12.86 -0.45 7.69e-34 Schizophrenia; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg23358479 chr7:1110784 C7orf50 -0.49 -8.2 -0.31 1.27e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.94 13.95 0.48 8.85e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs397969 0.646 rs6813 chr17:19808445 C/T cg13482628 chr17:19912719 NA -0.36 -7.84 -0.3 1.93e-14 Platelet count; BRCA cis rs10754283 0.967 rs2390763 chr1:90105688 A/G cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs734999 0.967 rs4486391 chr1:2513055 A/T cg18854424 chr1:2615690 NA 0.32 8.05 0.3 4.04e-15 Ulcerative colitis; BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.05 -21.65 -0.65 2.32e-78 Gut microbiome composition (summer); BRCA cis rs10489202 0.583 rs203782 chr1:167882386 A/G cg25738037 chr1:168025549 DCAF6 0.28 8.08 0.3 3.29e-15 Schizophrenia; BRCA cis rs7248779 1.000 rs7248779 chr19:2403564 G/T cg22729335 chr19:2427816 TIMM13 -0.58 -12.16 -0.43 9.91e-31 Cortisol levels (saliva); BRCA cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg04450456 chr4:17643702 FAM184B -0.31 -9.18 -0.34 5.69e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg13047869 chr3:10149882 C3orf24 -0.6 -12.72 -0.45 3.33e-33 Alzheimer's disease; BRCA cis rs6542838 0.702 rs4851167 chr2:99496303 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.31 -0.31 5.73e-16 Fear of minor pain; BRCA cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.18 0.68 1e-86 Chronic sinus infection; BRCA trans rs11098499 0.738 rs28408407 chr4:120376030 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.85 0.3 1.76e-14 Corneal astigmatism; BRCA cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg17507749 chr15:85114479 UBE2QP1 0.56 10.59 0.39 3.04e-24 Schizophrenia; BRCA cis rs7959452 0.535 rs10878953 chr12:69674187 A/G cg20891283 chr12:69753455 YEATS4 0.48 12.6 0.45 1.09e-32 Blood protein levels; BRCA trans rs9858542 0.953 rs1987628 chr3:49399259 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.03 -0.34 1.96e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg22800045 chr5:56110881 MAP3K1 0.56 10.53 0.38 5.3e-24 Initial pursuit acceleration; BRCA cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.61 0.53 9.41e-47 Colorectal cancer; BRCA cis rs2013441 1.000 rs17686798 chr17:20029170 A/C cg13482628 chr17:19912719 NA -0.37 -8.16 -0.31 1.72e-15 Obesity-related traits; BRCA cis rs2243480 1.000 rs73142166 chr7:65375832 A/G cg18252515 chr7:66147081 NA -0.88 -12.19 -0.43 6.77e-31 Diabetic kidney disease; BRCA cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg05283184 chr6:79620031 NA -0.41 -10.51 -0.38 6.1e-24 Intelligence (multi-trait analysis); BRCA cis rs12188164 0.620 rs56070387 chr5:482531 A/T cg15640734 chr5:494837 SLC9A3 -0.42 -8.2 -0.31 1.33e-15 Cystic fibrosis severity; BRCA cis rs7633857 0.537 rs1580253 chr3:160767150 T/C cg03342759 chr3:160939853 NMD3 -0.53 -10.69 -0.39 1.16e-24 Educational attainment (years of education); BRCA cis rs7011049 1.000 rs72643586 chr8:53847859 A/T cg26025543 chr8:53854495 NA 0.55 9.57 0.35 2.31e-20 Systolic blood pressure; BRCA cis rs6882046 0.513 rs647983 chr5:88048071 T/C cg22951263 chr5:87985283 NA -0.38 -10.74 -0.39 7.32e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg23583168 chr7:148888333 NA -0.83 -18.82 -0.6 3.25e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs597539 0.652 rs627731 chr11:68698663 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 17.55 0.57 1.49e-56 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs9457247 0.508 rs9457268 chr6:167503639 A/T cg07741184 chr6:167504864 NA 0.32 9.77 0.36 4.04e-21 Crohn's disease; BRCA cis rs2455799 0.573 rs2255248 chr3:15754849 A/G cg16303742 chr3:15540471 COLQ 0.34 8.15 0.31 1.9e-15 Mean platelet volume; BRCA cis rs2882667 0.690 rs288007 chr5:138230628 C/T cg04439458 chr5:138467593 SIL1 -0.34 -8.43 -0.32 2.3e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1862618 0.802 rs252900 chr5:56185281 T/A cg12311346 chr5:56204834 C5orf35 -0.81 -16.08 -0.54 4.04e-49 Initial pursuit acceleration; BRCA cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 6.83e-41 Motion sickness; BRCA cis rs9486715 0.867 rs2499775 chr6:97007340 C/T cg06623918 chr6:96969491 KIAA0776 -0.92 -27.27 -0.73 3.36e-109 Headache; BRCA cis rs4332037 0.539 rs4719416 chr7:2106608 G/A cg23422044 chr7:1970798 MAD1L1 -0.49 -10.09 -0.37 2.49e-22 Bipolar disorder; BRCA cis rs10789491 1.000 rs1258061 chr1:47105000 G/A cg15501359 chr1:47185051 KIAA0494 -0.65 -17.84 -0.58 4.36e-58 Response to hepatitis C treatment; BRCA cis rs9361491 0.510 rs1507151 chr6:79483246 T/C cg05283184 chr6:79620031 NA -0.35 -8.0 -0.3 5.95e-15 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.966 rs6891559 chr5:140145206 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.43 -10.01 -0.37 5.17e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs10193935 1.000 rs12612527 chr2:42392099 T/C cg27598129 chr2:42591480 NA -0.98 -14.69 -0.5 2.66e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs10416265 0.516 rs1270252 chr19:33623604 G/A cg17764715 chr19:33622953 WDR88 -0.51 -8.13 -0.31 2.22e-15 Bone properties (heel); BRCA cis rs13108904 0.905 rs34490749 chr4:1217981 A/G cg00684032 chr4:1343700 KIAA1530 0.32 7.88 0.3 1.42e-14 Obesity-related traits; BRCA trans rs35110281 0.837 rs12627667 chr21:45071396 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.32 0.31 5.29e-16 Mean corpuscular volume; BRCA cis rs7851660 0.967 rs7847126 chr9:100600635 A/C cg13688889 chr9:100608707 NA -0.36 -8.64 -0.32 4.6e-17 Strep throat; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg26608667 chr7:1196370 ZFAND2A 0.42 9.24 0.34 3.62e-19 Longevity;Endometriosis; BRCA cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg10802521 chr3:52805072 NEK4 -0.33 -8.41 -0.32 2.72e-16 Bipolar disorder; BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -11.96 -0.43 6.6e-30 Alzheimer's disease; BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg00106254 chr7:1943704 MAD1L1 -0.39 -9.11 -0.34 1.02e-18 Bipolar disorder and schizophrenia; BRCA cis rs6942756 0.531 rs9649531 chr7:128927659 T/C cg02491457 chr7:128862824 NA 0.44 9.19 0.34 5.67e-19 White matter hyperintensity burden; BRCA cis rs7772486 0.692 rs2265915 chr6:146194332 A/T cg13319975 chr6:146136371 FBXO30 -0.44 -10.14 -0.37 1.67e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg13880726 chr7:1868755 MAD1L1 0.52 9.81 0.36 2.93e-21 Bipolar disorder and schizophrenia; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg07308232 chr7:1071921 C7orf50 -0.49 -10.26 -0.38 5.79e-23 Longevity;Endometriosis; BRCA cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -10.89 -0.4 1.86e-25 Schizophrenia; BRCA cis rs1843834 1.000 rs1565072 chr2:225545245 C/T cg22455342 chr2:225449267 CUL3 -0.38 -9.2 -0.34 5.15e-19 IgE levels in asthmatics (D.p. specific); BRCA cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.7 -0.33 2.85e-17 Glomerular filtration rate (creatinine); BRCA cis rs1801251 0.963 rs13424351 chr2:233573629 A/G cg25237894 chr2:233734115 C2orf82 0.38 10.92 0.4 1.47e-25 Coronary artery disease; BRCA cis rs4642101 0.737 rs6767504 chr3:12826667 C/T cg05775895 chr3:12838266 CAND2 0.35 7.97 0.3 7.22e-15 QRS complex (12-leadsum); BRCA cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg24692254 chr21:30365293 RNF160 0.79 22.17 0.66 3.3e-81 Dental caries; BRCA cis rs2835872 0.758 rs1709821 chr21:39035622 T/C cg06728970 chr21:39037746 KCNJ6 0.45 12.84 0.45 9.59e-34 Electroencephalographic traits in alcoholism; BRCA cis rs1577917 0.771 rs7762321 chr6:86412146 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.34 9.52 0.35 3.35e-20 Response to antipsychotic treatment; BRCA cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg06618935 chr21:46677482 NA -0.36 -8.13 -0.31 2.26e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2153535 0.601 rs2327059 chr6:8447071 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg10523679 chr1:76189770 ACADM 0.76 15.67 0.53 4.33e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs60843830 0.661 rs7561648 chr2:105171 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.49 9.28 0.34 2.51e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs798554 0.704 rs798531 chr7:2770067 G/C cg09658497 chr7:2847517 GNA12 -0.39 -7.93 -0.3 9.76e-15 Height; BRCA cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg00684032 chr4:1343700 KIAA1530 0.33 8.31 0.31 5.59e-16 Obesity-related traits; BRCA cis rs3096299 0.933 rs2965824 chr16:89455306 A/G cg02187348 chr16:89574699 SPG7 0.4 9.25 0.34 3.24e-19 Multiple myeloma (IgH translocation); BRCA cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.27 -0.34 2.9e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs34375054 0.660 rs12578446 chr12:125605887 A/G cg25124228 chr12:125621409 AACS -0.54 -10.81 -0.39 3.82e-25 Post bronchodilator FEV1/FVC ratio; BRCA cis rs3784262 0.692 rs4646581 chr15:58307898 C/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.08 -0.37 2.74e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4953076 0.573 rs13008237 chr2:44404902 A/G cg04920474 chr2:44395004 PPM1B 0.48 10.18 0.37 1.15e-22 Height; BRCA cis rs11190604 1.000 rs2489040 chr10:102331298 G/A cg07080220 chr10:102295463 HIF1AN 0.55 12.45 0.44 5.37e-32 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg18765753 chr7:1198926 ZFAND2A -0.4 -9.0 -0.34 2.53e-18 Longevity;Endometriosis; BRCA cis rs12477438 0.520 rs2632277 chr2:99778985 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.62 0.75 1.49e-116 Chronic sinus infection; BRCA cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs11105298 0.891 rs10858864 chr12:89846230 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.85 -0.36 2.02e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.0 -0.37 5.74e-22 Alzheimer's disease (late onset); BRCA cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg11952622 chr19:58962976 ZNF324B 0.46 9.58 0.35 2.18e-20 Uric acid clearance; BRCA cis rs11098499 0.532 rs4504231 chr4:120586891 G/A cg09307838 chr4:120376055 NA 0.56 11.44 0.41 1.1e-27 Corneal astigmatism; BRCA cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg21770322 chr7:97807741 LMTK2 0.44 11.76 0.42 4.66e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs11191205 0.644 rs10883667 chr10:103384849 A/T cg15320455 chr10:103880129 LDB1 0.46 7.88 0.3 1.41e-14 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.783 rs10028584 chr4:98962404 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.34 0.38 2.73e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.917 rs36066 chr5:148419771 A/G cg12140854 chr5:148520817 ABLIM3 -0.43 -8.95 -0.33 3.71e-18 Breast cancer; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs1499614 1.000 rs2707832 chr7:66136549 C/T cg18252515 chr7:66147081 NA -1.06 -16.01 -0.54 9.39e-49 Gout; BRCA cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.77 -0.36 4.24e-21 IgG glycosylation; BRCA cis rs7772486 0.743 rs62433835 chr6:146032688 C/G cg23711669 chr6:146136114 FBXO30 -0.7 -16.89 -0.56 3.45e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.546 rs11727151 chr4:98837353 A/C cg05340658 chr4:99064831 C4orf37 0.57 11.0 0.4 6.93e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs41271473 0.500 rs4440831 chr1:228887522 C/T cg00850481 chr1:228891306 NA 0.36 7.93 0.3 9.96e-15 Chronic lymphocytic leukemia; BRCA cis rs68170813 0.559 rs75203426 chr7:107017589 G/C cg02696742 chr7:106810147 HBP1 -0.55 -8.74 -0.33 2.05e-17 Coronary artery disease; BRCA cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03352830 chr11:487213 PTDSS2 -0.87 -13.59 -0.47 3.99e-37 Body mass index; BRCA trans rs7618501 0.699 rs2777888 chr3:49898000 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.37 10.22 0.37 8.54e-23 Intelligence (multi-trait analysis); BRCA cis rs4660306 1.000 rs2077808 chr1:45988115 G/A cg24296786 chr1:45957014 TESK2 0.43 8.66 0.32 3.96e-17 Homocysteine levels; BRCA cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg00277334 chr10:82204260 NA -0.84 -23.82 -0.69 2.94e-90 Post bronchodilator FEV1; BRCA cis rs4919694 1.000 rs77969925 chr10:104649357 C/T cg04362960 chr10:104952993 NT5C2 0.9 14.59 0.5 8.3e-42 Arsenic metabolism; BRCA cis rs36051895 0.623 rs2146041 chr9:5262911 A/G cg02405213 chr9:5042618 JAK2 -0.48 -8.91 -0.33 5.49e-18 Pediatric autoimmune diseases; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg12444411 chr7:2802554 GNA12 0.35 8.7 0.33 2.83e-17 Height; BRCA cis rs4819852 1.000 rs1034565 chr22:19984211 A/G cg07821417 chr22:19972146 ARVCF -0.45 -10.46 -0.38 9.83e-24 Pulse pressure; BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg22920501 chr2:26401640 FAM59B -0.9 -15.98 -0.53 1.37e-48 Gut microbiome composition (summer); BRCA trans rs1005277 0.505 rs200937 chr10:38135772 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -9.63 -0.36 1.33e-20 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.09e-16 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.791 rs2903151 chr4:99027218 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.943 rs4801803 chr19:37966923 A/G cg18154014 chr19:37997991 ZNF793 -0.63 -11.9 -0.43 1.19e-29 Coronary artery calcification; BRCA cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg18876405 chr7:65276391 NA -0.49 -11.05 -0.4 4.13e-26 Aortic root size; BRCA cis rs67460515 0.527 rs34221255 chr3:160854123 T/C cg03342759 chr3:160939853 NMD3 -0.63 -13.08 -0.46 8.04e-35 Parkinson's disease; BRCA cis rs9859260 0.744 rs539816 chr3:195784076 T/A cg12923728 chr3:195709715 SDHAP1 0.38 7.83 0.3 2.01e-14 Mean corpuscular volume; BRCA cis rs7809950 1.000 rs3801948 chr7:107238447 A/T cg23024343 chr7:107201750 COG5 -0.4 -9.13 -0.34 8.92e-19 Coronary artery disease; BRCA cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11644478 chr21:40555479 PSMG1 0.84 18.75 0.6 8.13e-63 Cognitive function; BRCA cis rs2204008 0.522 rs12370263 chr12:38113311 A/G cg26384229 chr12:38710491 ALG10B 0.66 14.44 0.5 3.92e-41 Bladder cancer; BRCA cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg24531977 chr5:56204891 C5orf35 1.07 22.49 0.66 5.77e-83 Initial pursuit acceleration; BRCA cis rs73001065 0.901 rs73002956 chr19:19578743 A/G cg03709012 chr19:19516395 GATAD2A 0.9 9.6 0.36 1.72e-20 LDL cholesterol; BRCA cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.21 0.46 2.22e-35 Bipolar disorder; BRCA cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg06238570 chr21:40685208 BRWD1 -0.44 -8.56 -0.32 8.23e-17 Cognitive function; BRCA cis rs3784262 0.669 rs12912093 chr15:58332583 A/G cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.85 -0.36 2.07e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4363385 0.782 rs2152993 chr1:152991695 C/A cg25856811 chr1:152973957 SPRR3 -0.31 -8.34 -0.31 4.69e-16 Inflammatory skin disease; BRCA cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg21918786 chr6:109611834 NA -0.45 -12.24 -0.44 4.08e-31 Reticulocyte fraction of red cells; BRCA cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg00080972 chr5:178986291 RUFY1 0.39 9.27 0.34 2.88e-19 Lung cancer; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.52 -0.52 2.52e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9828933 0.752 rs73117082 chr3:63947565 A/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.75 -11.9 -0.43 1.27e-29 Type 2 diabetes; BRCA cis rs12682352 0.652 rs1567398 chr8:8726804 A/C cg15556689 chr8:8085844 FLJ10661 -0.38 -10.48 -0.38 8.2e-24 Neuroticism; BRCA cis rs4555082 0.834 rs2735817 chr14:105717796 A/G cg27165867 chr14:105738592 BRF1 0.38 8.81 0.33 1.2e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg25801113 chr15:45476975 SHF 0.31 8.03 0.3 4.63e-15 Uric acid levels; BRCA cis rs11984145 1.000 rs73121384 chr7:38865187 T/C cg19327137 chr7:38886074 VPS41 0.5 7.91 0.3 1.15e-14 Cognitive performance; BRCA cis rs6060717 0.536 rs11699899 chr20:34525646 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.03 -0.3 4.56e-15 Hip circumference adjusted for BMI; BRCA cis rs6547741 0.967 rs4665986 chr2:27755168 G/A cg27432699 chr2:27873401 GPN1 0.47 9.92 0.37 1.17e-21 Oral cavity cancer; BRCA cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg22907277 chr7:1156413 C7orf50 0.48 11.63 0.42 1.76e-28 Longevity;Endometriosis; BRCA cis rs798554 0.704 rs709282 chr7:2769921 G/A cg13628971 chr7:2884303 GNA12 0.4 8.72 0.33 2.45e-17 Height; BRCA cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg07636037 chr3:49044803 WDR6 0.97 27.43 0.74 4.56e-110 Parkinson's disease; BRCA cis rs6138458 0.847 rs56312312 chr20:24959386 C/A cg26195577 chr20:24973756 C20orf3 0.98 21.49 0.65 1.56e-77 Blood protein levels; BRCA cis rs6570726 0.935 rs421690 chr6:145834594 A/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.38 -0.31 3.37e-16 Monocyte percentage of white cells; BRCA cis rs921968 0.591 rs13421421 chr2:219519286 A/G cg02176678 chr2:219576539 TTLL4 0.42 11.0 0.4 6.79e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs2130392 0.924 rs873687 chr4:185638853 G/A cg21366198 chr4:185655624 MLF1IP 0.35 8.02 0.3 5.05e-15 Kawasaki disease; BRCA cis rs1003719 0.715 rs2835653 chr21:38558636 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.38 8.3 0.31 6.41e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1595825 0.891 rs16823385 chr2:198602101 G/A cg19156104 chr2:198669113 PLCL1 -0.47 -8.25 -0.31 8.74e-16 Ulcerative colitis; BRCA cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg23887609 chr12:130822674 PIWIL1 0.43 9.33 0.35 1.71e-19 Menopause (age at onset); BRCA cis rs12995491 0.933 rs12995212 chr2:88527184 C/T cg04511125 chr2:88470314 THNSL2 -0.45 -8.77 -0.33 1.64e-17 Response to metformin (IC50); BRCA cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg00677455 chr12:58241039 CTDSP2 0.77 18.71 0.59 1.29e-62 Multiple sclerosis; BRCA cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg06618935 chr21:46677482 NA -0.37 -8.11 -0.31 2.68e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs870825 0.616 rs28459754 chr4:185636280 C/A cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs13046373 0.535 rs13051135 chr21:32005278 G/A cg22337977 chr21:31811175 KRTAP15-1 0.33 7.93 0.3 9.69e-15 HDL cholesterol; BRCA cis rs2243480 1.000 rs1553174 chr7:65731194 T/C cg18252515 chr7:66147081 NA 1.04 15.68 0.53 4.14e-47 Diabetic kidney disease; BRCA cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg22800045 chr5:56110881 MAP3K1 0.66 12.33 0.44 1.69e-31 Initial pursuit acceleration; BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -8.64 -0.32 4.6e-17 Bipolar disorder and schizophrenia; BRCA cis rs4363385 0.747 rs4240868 chr1:152981599 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.11e-18 Inflammatory skin disease; BRCA cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg13271783 chr10:134563150 INPP5A -0.5 -9.57 -0.35 2.28e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6088590 0.687 rs8115656 chr20:33282780 G/C cg24642439 chr20:33292090 TP53INP2 0.6 13.29 0.47 8.92e-36 Coronary artery disease; BRCA cis rs8180040 0.620 rs6414435 chr3:47121140 A/G cg27129171 chr3:47204927 SETD2 0.71 17.26 0.56 4.46e-55 Colorectal cancer; BRCA cis rs11098499 0.535 rs7671759 chr4:120248094 A/C cg09307838 chr4:120376055 NA 0.63 13.21 0.46 2.1e-35 Corneal astigmatism; BRCA cis rs7044106 0.762 rs1547267 chr9:123408736 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 14.11 0.49 1.48e-39 Hip circumference adjusted for BMI; BRCA cis rs2011503 0.943 rs79370636 chr19:19614289 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -9.02 -0.34 2.19e-18 Bipolar disorder; BRCA cis rs4631830 0.720 rs11004415 chr10:51498181 G/A cg16070123 chr10:51489643 NA 0.35 7.85 0.3 1.73e-14 Prostate-specific antigen levels; BRCA cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg15017067 chr4:17643749 FAM184B 0.32 10.0 0.37 5.88e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs654950 0.776 rs2759252 chr1:42021854 G/A cg06885757 chr1:42089581 HIVEP3 -0.32 -10.75 -0.39 6.91e-25 Airway imaging phenotypes; BRCA cis rs10752881 0.905 rs12132262 chr1:182989949 T/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.88 0.56 3.66e-53 Colorectal cancer; BRCA cis rs9987353 0.566 rs13260067 chr8:9071033 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -9.92 -0.37 1.1e-21 Recombination measurement; BRCA trans rs1997103 1.000 rs6950311 chr7:55400990 G/A cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs514406 0.893 rs512723 chr1:53343880 C/T cg27535305 chr1:53392650 SCP2 0.39 9.17 0.34 6.67e-19 Monocyte count; BRCA trans rs10506458 0.834 rs12426860 chr12:63387948 C/T cg22491629 chr6:157744540 C6orf35 -0.65 -11.68 -0.42 1.06e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg01448562 chr3:133502909 NA 0.6 14.59 0.5 7.88e-42 Iron status biomarkers; BRCA cis rs9560113 0.959 rs4771756 chr13:112176083 T/G cg10483660 chr13:112241077 NA 0.32 7.93 0.3 9.77e-15 Menarche (age at onset); BRCA cis rs7264396 0.690 rs2425180 chr20:34447160 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.13 0.31 2.28e-15 Total cholesterol levels; BRCA cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg24642439 chr20:33292090 TP53INP2 -0.54 -11.67 -0.42 1.13e-28 Glomerular filtration rate (creatinine); BRCA cis rs1570989 0.543 rs6458035 chr6:12015296 A/G cg17804551 chr6:12015979 HIVEP1 0.4 9.56 0.35 2.44e-20 Alcohol and nicotine co-dependence; BRCA cis rs9790314 0.846 rs7636941 chr3:160993928 A/G cg03342759 chr3:160939853 NMD3 -0.71 -17.82 -0.58 5.97e-58 Morning vs. evening chronotype; BRCA cis rs11098499 0.863 rs1552095 chr4:120460306 A/G cg09307838 chr4:120376055 NA 0.69 13.77 0.48 5.85e-38 Corneal astigmatism; BRCA cis rs9682041 0.696 rs11917147 chr3:170088448 C/T cg11886554 chr3:170076028 SKIL 0.51 10.19 0.37 1.03e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg13852791 chr20:30311386 BCL2L1 0.79 15.29 0.52 3.19e-45 Mean corpuscular hemoglobin; BRCA trans rs7615952 0.599 rs1044215 chr3:125725559 C/G cg07211511 chr3:129823064 LOC729375 -0.6 -11.53 -0.41 4.5e-28 Blood pressure (smoking interaction); BRCA cis rs7904368 0.951 rs7905776 chr10:16853609 C/T cg23933602 chr10:16859644 RSU1 0.63 11.74 0.42 5.94e-29 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs2204008 0.560 rs1315354 chr12:38165716 A/G cg26384229 chr12:38710491 ALG10B -0.44 -10.0 -0.37 5.69e-22 Bladder cancer; BRCA cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg04450456 chr4:17643702 FAM184B 0.36 10.39 0.38 1.81e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg09455208 chr3:40491958 NA 0.53 11.94 0.43 8.23e-30 Renal cell carcinoma; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 15.12 0.51 2.34e-44 Platelet count; BRCA cis rs12950390 0.853 rs11079790 chr17:45853626 G/A cg24803719 chr17:45855879 NA -0.31 -8.29 -0.31 6.67e-16 IgG glycosylation; BRCA cis rs7520050 0.931 rs785472 chr1:46518288 T/A cg24296786 chr1:45957014 TESK2 0.41 9.22 0.34 4.28e-19 Red blood cell count;Reticulocyte count; BRCA cis rs881375 0.967 rs2109895 chr9:123677827 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.8 0.39 4.53e-25 Rheumatoid arthritis; BRCA cis rs870825 0.616 rs28672716 chr4:185647345 G/A cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.2 -18.94 -0.6 8.07e-64 Hemostatic factors and hematological phenotypes; BRCA cis rs7246967 0.673 rs34676724 chr19:22918473 A/C cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.71 -0.57 2.11e-57 Chronic sinus infection; BRCA cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg24397884 chr7:158709396 WDR60 -0.97 -24.82 -0.7 9.75e-96 Height; BRCA cis rs79976124 0.760 rs74295030 chr6:66654441 T/C cg07460842 chr6:66804631 NA 0.6 10.41 0.38 1.57e-23 Type 2 diabetes; BRCA cis rs17376456 0.825 rs10038828 chr5:93124056 C/T cg21475434 chr5:93447410 FAM172A 0.68 8.8 0.33 1.26e-17 Diabetic retinopathy; BRCA cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg08219700 chr8:58056026 NA 0.45 8.31 0.31 5.83e-16 Developmental language disorder (linguistic errors); BRCA cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg06159980 chr1:16340746 HSPB7 0.4 8.46 0.32 1.85e-16 Dilated cardiomyopathy; BRCA cis rs250677 0.522 rs12523526 chr5:148349107 A/C cg18129178 chr5:148520854 ABLIM3 0.54 10.29 0.38 4.51e-23 Breast cancer; BRCA cis rs6964587 1.000 rs10234071 chr7:91645152 C/G cg17063962 chr7:91808500 NA -0.52 -12.28 -0.44 2.98e-31 Breast cancer; BRCA cis rs34172651 0.876 rs1862451 chr16:24803620 A/G cg00152838 chr16:24741724 TNRC6A -0.35 -7.88 -0.3 1.47e-14 Intelligence (multi-trait analysis); BRCA cis rs9341808 0.727 rs1324120 chr6:80976125 G/C cg08355045 chr6:80787529 NA 0.37 9.55 0.35 2.77e-20 Sitting height ratio; BRCA cis rs6545883 0.895 rs6545871 chr2:61692203 G/T cg15711740 chr2:61764176 XPO1 -0.57 -14.37 -0.49 9e-41 Tuberculosis; BRCA cis rs372883 0.600 rs1236460 chr21:30615513 G/A cg24692254 chr21:30365293 RNF160 -0.48 -10.45 -0.38 1.04e-23 Pancreatic cancer; BRCA cis rs9392556 0.829 rs693953 chr6:4120565 A/T cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -8.2 -0.31 1.37e-15 Blood metabolite levels; BRCA cis rs6500602 0.826 rs11076831 chr16:4460133 A/G cg08645402 chr16:4508243 NA -0.38 -8.27 -0.31 7.81e-16 Schizophrenia; BRCA cis rs344364 0.511 rs1742473 chr16:1953095 T/C cg09830162 chr16:1889614 FAHD1;C16orf73 -0.51 -9.24 -0.34 3.62e-19 Glomerular filtration rate in chronic kidney disease; BRCA cis rs12618769 0.597 rs3754888 chr2:99090674 T/C cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg10729496 chr3:10149963 C3orf24 0.48 8.98 0.33 3.08e-18 Alzheimer's disease; BRCA cis rs9325144 0.624 rs10506126 chr12:39123244 G/A cg26384229 chr12:38710491 ALG10B -0.45 -10.82 -0.39 3.75e-25 Morning vs. evening chronotype; BRCA cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg05623727 chr3:50126028 RBM5 -0.42 -10.06 -0.37 3.36e-22 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.775 rs3900361 chr12:38238936 A/G cg26384229 chr12:38710491 ALG10B -0.64 -14.7 -0.5 2.47e-42 Bladder cancer; BRCA cis rs4319547 1.000 rs9705654 chr12:123083508 T/C cg05707623 chr12:122985044 ZCCHC8 -0.47 -9.66 -0.36 1.03e-20 Body mass index; BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.27e-19 Tonsillectomy; BRCA trans rs9951602 0.512 rs9946138 chr18:76654608 A/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.28 0.59 2.2e-60 Obesity-related traits; BRCA cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg06221963 chr1:154839813 KCNN3 -0.55 -15.17 -0.51 1.23e-44 Prostate cancer; BRCA cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg05294307 chr14:35346193 BAZ1A -0.62 -10.51 -0.38 6.36e-24 Psoriasis; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 1e-20 Total body bone mineral density; BRCA cis rs644148 0.738 rs2686768 chr19:44995990 C/T cg15540054 chr19:45004280 ZNF180 -0.41 -8.41 -0.32 2.62e-16 Personality dimensions; BRCA cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.59 -0.45 1.26e-32 Personality dimensions; BRCA cis rs8180040 0.966 rs11707895 chr3:47574937 G/A cg27129171 chr3:47204927 SETD2 -0.65 -14.25 -0.49 3.45e-40 Colorectal cancer; BRCA cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.7 0.42 8.37e-29 Hip circumference adjusted for BMI; BRCA cis rs875971 0.798 rs6460304 chr7:65964728 G/A cg18876405 chr7:65276391 NA 0.51 11.55 0.42 3.58e-28 Aortic root size; BRCA cis rs801193 0.844 rs732465 chr7:65998450 T/C cg18876405 chr7:65276391 NA 0.58 13.64 0.47 2.35e-37 Aortic root size; BRCA cis rs7772486 0.720 rs7752286 chr6:146072662 C/T cg23711669 chr6:146136114 FBXO30 -0.79 -19.16 -0.6 5.32e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg16606324 chr3:10149918 C3orf24 0.57 10.03 0.37 4.25e-22 Alzheimer's disease; BRCA cis rs2522056 0.808 rs17771891 chr5:131744202 A/G cg24060327 chr5:131705240 SLC22A5 -0.56 -9.25 -0.34 3.45e-19 Lymphocyte counts;Fibrinogen; BRCA cis rs1994135 0.654 rs11052759 chr12:33724126 G/A cg06521331 chr12:34319734 NA -0.53 -9.28 -0.34 2.62e-19 Resting heart rate; BRCA cis rs2731664 0.740 rs2731670 chr5:176848019 G/T cg23176889 chr5:176863531 GRK6 0.52 13.64 0.47 2.22e-37 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg23583168 chr7:148888333 NA -0.95 -25.37 -0.71 9.16e-99 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg11764359 chr7:65958608 NA 0.78 18.21 0.58 5.34e-60 Aortic root size; BRCA cis rs7824557 0.836 rs2736378 chr8:11119760 G/A cg21775007 chr8:11205619 TDH -0.59 -11.5 -0.41 5.8e-28 Retinal vascular caliber; BRCA cis rs6121246 0.909 rs1994251 chr20:30287328 T/G cg13852791 chr20:30311386 BCL2L1 0.86 16.68 0.55 4.04e-52 Mean corpuscular hemoglobin; BRCA cis rs13161895 0.818 rs78282770 chr5:179483686 T/A cg02702477 chr5:179499311 RNF130 0.57 9.99 0.37 6.47e-22 LDL cholesterol; BRCA cis rs847577 0.748 rs940432 chr7:97716483 G/A cg21770322 chr7:97807741 LMTK2 0.58 16.99 0.56 1.12e-53 Breast cancer; BRCA cis rs11893307 0.536 rs6719798 chr2:191677664 C/T cg05765582 chr2:191677683 NA 0.44 7.92 0.3 1.09e-14 Mean platelet volume; BRCA trans rs9291683 0.632 rs11734786 chr4:10041499 A/C cg26043149 chr18:55253948 FECH 0.42 9.14 0.34 8.39e-19 Bone mineral density; BRCA cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg27541892 chr1:1571801 CDK11B 0.38 8.47 0.32 1.71e-16 Body mass index; BRCA cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg00750074 chr16:89608354 SPG7 -0.41 -10.96 -0.4 1e-25 Multiple myeloma (IgH translocation); BRCA cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg17971929 chr21:40555470 PSMG1 0.77 18.18 0.58 7.78e-60 Cognitive function; BRCA cis rs858239 0.601 rs28673077 chr7:23250854 C/T cg23682824 chr7:23144976 KLHL7 0.35 8.61 0.32 5.6e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.46 0.61 1.39e-66 Alzheimer's disease; BRCA cis rs9297145 0.565 rs941001 chr7:98735185 A/T cg05967295 chr7:98741636 SMURF1 -0.62 -13.39 -0.47 3.23e-36 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs36051895 0.695 rs4527935 chr9:5016455 A/T cg02405213 chr9:5042618 JAK2 -0.49 -8.7 -0.33 2.77e-17 Pediatric autoimmune diseases; BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg02038168 chr22:39784481 NA 0.43 8.24 0.31 9.9e-16 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs2339494 chr1:152975143 G/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.59 -0.35 1.92e-20 Inflammatory skin disease; BRCA cis rs10504073 0.605 rs62507176 chr8:49930321 G/A cg00325661 chr8:49890786 NA 0.54 15.54 0.52 1.89e-46 Blood metabolite ratios; BRCA cis rs7072216 0.726 rs4474372 chr10:100164571 C/T cg26618903 chr10:100175079 PYROXD2 -0.29 -8.5 -0.32 1.3e-16 Metabolite levels; BRCA cis rs1003719 0.715 rs2835649 chr21:38552230 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.26 0.49 2.85e-40 Eye color traits; BRCA cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg11266682 chr4:10021025 SLC2A9 0.41 10.86 0.39 2.47e-25 Bone mineral density; BRCA cis rs4363385 0.747 rs1933383 chr1:152963468 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.2 -0.31 1.31e-15 Inflammatory skin disease; BRCA cis rs709400 0.663 rs8015918 chr14:103942991 A/G cg26031613 chr14:104095156 KLC1 0.75 16.33 0.54 2.24e-50 Body mass index; BRCA cis rs6752107 0.935 rs10929325 chr2:234151031 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.49 10.81 0.39 4.12e-25 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9868809 0.505 rs35064573 chr3:48740280 C/A cg07636037 chr3:49044803 WDR6 -0.57 -7.86 -0.3 1.61e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs9393777 0.513 rs9368451 chr6:26654333 A/G cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg02951883 chr7:2050386 MAD1L1 -0.56 -13.44 -0.47 1.83e-36 Bipolar disorder and schizophrenia; BRCA cis rs2386661 0.591 rs11255051 chr10:5653450 A/G cg17085576 chr10:5658249 NA -0.36 -8.88 -0.33 6.51e-18 Breast cancer; BRCA cis rs2404602 0.735 rs11857015 chr15:76649390 T/C cg23625390 chr15:77176239 SCAPER -0.53 -12.57 -0.45 1.61e-32 Blood metabolite levels; BRCA cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg26597838 chr10:835615 NA 0.95 14.42 0.5 5.19e-41 Eosinophil percentage of granulocytes; BRCA cis rs586533 0.846 rs646067 chr11:99497122 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.02 0.3 5.08e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg26384229 chr12:38710491 ALG10B -0.51 -13.3 -0.47 8.1e-36 Morning vs. evening chronotype; BRCA cis rs586533 0.881 rs12806028 chr11:99512171 C/A cg22878054 chr11:99397252 CNTN5 0.31 7.84 0.3 1.85e-14 Depressive symptoms (multi-trait analysis); BRCA trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg23505145 chr19:12996616 KLF1 0.56 12.68 0.45 5.18e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs6565180 1.000 rs68051857 chr16:30360011 A/G cg17640201 chr16:30407289 ZNF48 -0.78 -20.01 -0.62 1.64e-69 Tonsillectomy; BRCA cis rs1215050 0.765 rs1588018 chr4:98756324 G/C cg05340658 chr4:99064831 C4orf37 0.45 10.37 0.38 2.18e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs8044868 0.530 rs2287999 chr16:72059149 A/G cg16558253 chr16:72132732 DHX38 -0.39 -9.52 -0.35 3.6e-20 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs11098499 0.779 rs7356491 chr4:120381974 C/T cg09307838 chr4:120376055 NA 0.76 17.1 0.56 2.9e-54 Corneal astigmatism; BRCA cis rs7395581 0.959 rs59663860 chr11:47276350 G/C cg25783544 chr11:47291846 MADD 0.43 9.49 0.35 4.43e-20 HDL cholesterol; BRCA trans rs8062405 0.754 rs62034323 chr16:28536473 C/T cg09719594 chr16:21412588 NA -0.35 -8.36 -0.31 3.87e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg05552183 chr6:42928497 GNMT 0.7 15.77 0.53 1.43e-47 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs12517041 1.000 rs71611220 chr5:23281005 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.27 -0.31 7.76e-16 Calcium levels; BRCA cis rs2304069 0.955 rs4288106 chr5:149394872 A/G cg10852222 chr5:149380144 HMGXB3;TIGD6 0.56 8.71 0.33 2.68e-17 HIV-1 control; BRCA cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg11833968 chr6:79620685 NA -0.45 -10.03 -0.37 4.43e-22 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg02733842 chr7:1102375 C7orf50 0.72 12.81 0.45 1.4e-33 Bronchopulmonary dysplasia; BRCA cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg00745463 chr17:30367425 LRRC37B -0.53 -8.87 -0.33 7.27e-18 Hip circumference adjusted for BMI; BRCA cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg20790798 chr5:1857306 NA -0.39 -9.18 -0.34 5.76e-19 Cardiovascular disease risk factors; BRCA cis rs10751667 0.600 rs1128413 chr11:1010694 C/T cg06064525 chr11:970664 AP2A2 -0.27 -7.85 -0.3 1.76e-14 Alzheimer's disease (late onset); BRCA trans rs11098499 0.691 rs2136911 chr4:120265859 G/A cg25214090 chr10:38739885 LOC399744 0.43 10.0 0.37 5.45e-22 Corneal astigmatism; BRCA cis rs13108904 0.934 rs13149952 chr4:1308437 C/G cg05665937 chr4:1216051 CTBP1 0.44 8.86 0.33 7.93e-18 Obesity-related traits; BRCA trans rs61931739 0.749 rs11053093 chr12:34231095 A/G cg26384229 chr12:38710491 ALG10B 0.44 10.72 0.39 8.67e-25 Morning vs. evening chronotype; BRCA cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.22e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -9.83 -0.36 2.58e-21 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs6761324 chr2:233582793 T/G cg25237894 chr2:233734115 C2orf82 0.4 11.43 0.41 1.15e-27 Coronary artery disease; BRCA cis rs6121246 0.909 rs6058460 chr20:30363071 G/A cg13852791 chr20:30311386 BCL2L1 0.84 16.49 0.55 3.83e-51 Mean corpuscular hemoglobin; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg16145915 chr7:1198662 ZFAND2A -0.46 -11.53 -0.42 4.43e-28 Longevity;Endometriosis; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg04166393 chr7:2884313 GNA12 0.47 8.97 0.33 3.31e-18 Height; BRCA cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.2 -0.41 1.07e-26 Extrinsic epigenetic age acceleration; BRCA cis rs6089584 0.566 rs55881457 chr20:60608424 G/A cg13770153 chr20:60521292 NA -0.38 -9.03 -0.34 2.07e-18 Body mass index; BRCA cis rs698813 0.604 rs768007 chr2:44487486 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.45 7.93 0.3 1.01e-14 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs4268898 0.717 rs3731626 chr2:24427864 G/A cg06627628 chr2:24431161 ITSN2 -0.71 -13.31 -0.47 7.78e-36 Asthma; BRCA cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg05623727 chr3:50126028 RBM5 0.51 12.87 0.45 6.91e-34 Body mass index; BRCA cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg11764359 chr7:65958608 NA 0.81 19.52 0.61 6.65e-67 Aortic root size; BRCA cis rs6964587 0.869 rs13237856 chr7:91551788 G/A cg17063962 chr7:91808500 NA -0.5 -11.74 -0.42 5.93e-29 Breast cancer; BRCA cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg26384229 chr12:38710491 ALG10B 0.58 13.55 0.47 5.8e-37 Bladder cancer; BRCA trans rs3858145 0.588 rs115455464 chr10:70038498 T/C cg04882175 chr6:131122610 NA -0.35 -8.35 -0.31 4.33e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg01579765 chr21:45077557 HSF2BP -0.47 -13.2 -0.46 2.38e-35 Mean corpuscular volume; BRCA trans rs7746199 0.736 rs34543938 chr6:27624640 A/G cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.96e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs10876993 0.928 rs813854 chr12:58071347 A/G cg18357645 chr12:58087776 OS9 0.48 13.63 0.47 2.49e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs3796619 1.000 rs3796619 chr4:1095281 A/G cg27284194 chr4:1044797 NA 0.44 9.35 0.35 1.5e-19 Recombination rate (males); BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg24642844 chr7:1081250 C7orf50 -0.91 -16.39 -0.54 1.21e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg25036284 chr2:26402008 FAM59B 0.95 15.98 0.53 1.27e-48 Gut microbiome composition (summer); BRCA cis rs7829975 0.682 rs7013471 chr8:8687325 A/G cg08975724 chr8:8085496 FLJ10661 -0.38 -8.22 -0.31 1.13e-15 Mood instability; BRCA cis rs9790314 0.663 rs13098884 chr3:160687386 A/G cg03342759 chr3:160939853 NMD3 0.45 8.76 0.33 1.72e-17 Morning vs. evening chronotype; BRCA trans rs35110281 0.720 rs162393 chr21:44942692 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.24 0.38 7.13e-23 Mean corpuscular volume; BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg03354898 chr7:1950403 MAD1L1 -0.47 -9.31 -0.35 2.02e-19 Bipolar disorder and schizophrenia; BRCA cis rs9463078 0.715 rs1891411 chr6:44760903 G/C cg25276700 chr6:44698697 NA 0.38 8.82 0.33 1.06e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1865760 1.000 rs9393675 chr6:25930116 G/A cg16482183 chr6:26056742 HIST1H1C 0.54 11.1 0.4 2.7e-26 Height; BRCA cis rs769267 0.930 rs4808965 chr19:19631655 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.09 0.3 2.92e-15 Tonsillectomy; BRCA cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg24977027 chr2:88469347 THNSL2 -0.56 -9.37 -0.35 1.24e-19 Plasma clusterin levels; BRCA cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg19748678 chr4:122722346 EXOSC9 0.74 16.01 0.54 9.39e-49 Type 2 diabetes; BRCA cis rs13256369 1.000 rs13282915 chr8:8570891 T/G cg17143192 chr8:8559678 CLDN23 0.55 10.77 0.39 5.9e-25 Obesity-related traits; BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.87 0.36 1.77e-21 Tonsillectomy; BRCA cis rs10464366 0.912 rs2030960 chr7:39106010 G/A cg18850127 chr7:39170497 POU6F2 0.39 8.26 0.31 8.58e-16 IgG glycosylation; BRCA cis rs921968 0.643 rs484085 chr2:219396684 C/T cg02176678 chr2:219576539 TTLL4 0.39 10.46 0.38 9.28e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs10911232 0.507 rs4652769 chr1:183009196 T/C ch.1.3577855R chr1:183094577 LAMC1 0.65 16.99 0.56 1.02e-53 Hypertriglyceridemia; BRCA cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg21770322 chr7:97807741 LMTK2 0.43 11.4 0.41 1.55e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.1 -0.31 2.87e-15 Bipolar disorder; BRCA cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg22800045 chr5:56110881 MAP3K1 0.62 11.8 0.42 3.17e-29 Initial pursuit acceleration; BRCA cis rs12618769 0.652 rs7585747 chr2:99219071 T/C cg10123293 chr2:99228465 UNC50 0.42 8.49 0.32 1.44e-16 Bipolar disorder; BRCA cis rs1577917 0.958 rs13207173 chr6:86457522 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.68 -0.45 4.8e-33 Response to antipsychotic treatment; BRCA cis rs13095912 1.000 rs13072759 chr3:185326391 G/A cg11274856 chr3:185301563 NA 0.36 8.84 0.33 9.31e-18 Systolic blood pressure; BRCA cis rs7246657 0.722 rs10409605 chr19:38123137 T/G cg23950597 chr19:37808831 NA -0.49 -8.51 -0.32 1.28e-16 Coronary artery calcification; BRCA cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4891159 0.790 rs9950025 chr18:74113596 C/G cg24786174 chr18:74118243 ZNF516 0.74 18.66 0.59 2.39e-62 Longevity; BRCA cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg26384229 chr12:38710491 ALG10B 0.69 15.68 0.53 4.01e-47 Bladder cancer; BRCA cis rs6831352 0.918 rs2851247 chr4:100046091 C/G cg13256891 chr4:100009986 ADH5 -0.54 -9.95 -0.37 8.56e-22 Alcohol dependence; BRCA cis rs6964587 0.869 rs6979024 chr7:91481512 T/C cg17063962 chr7:91808500 NA -0.53 -11.96 -0.43 6.84e-30 Breast cancer; BRCA cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg26384229 chr12:38710491 ALG10B 0.83 22.45 0.66 9.57e-83 Heart rate; BRCA cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg24692254 chr21:30365293 RNF160 -0.62 -15.86 -0.53 5.18e-48 Dental caries; BRCA cis rs1577917 0.917 rs35038582 chr6:86721305 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.47 -12.5 -0.44 3.27e-32 Response to antipsychotic treatment; BRCA cis rs7246657 0.943 rs4801803 chr19:37966923 A/G cg23950597 chr19:37808831 NA 0.74 13.03 0.46 1.37e-34 Coronary artery calcification; BRCA cis rs7945718 0.875 rs6486057 chr11:12810338 T/A cg25843174 chr11:12811716 TEAD1 0.23 8.73 0.33 2.16e-17 Educational attainment (years of education); BRCA trans rs11764590 0.671 rs56226325 chr7:2078981 C/T cg25206134 chr2:45395956 NA 0.49 7.82 0.3 2.14e-14 Neuroticism; BRCA cis rs12611088 0.541 rs2682579 chr19:44012609 T/C cg15012607 chr19:44012195 ETHE1 -0.35 -9.17 -0.34 6.41e-19 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs796364 0.806 rs11674293 chr2:201026743 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -9.84 -0.36 2.22e-21 Schizophrenia; BRCA cis rs13191362 1.000 rs13213408 chr6:162998049 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.28 0.44 2.75e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9399137 0.507 rs7761964 chr6:135314265 T/C cg22676075 chr6:135203613 NA 0.44 8.6 0.32 6.06e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.8 -0.42 3.39e-29 Colorectal cancer; BRCA cis rs7020830 0.894 rs13300951 chr9:37146627 A/G cg14294708 chr9:37120828 ZCCHC7 1.18 42.36 0.86 1.03e-187 Schizophrenia; BRCA cis rs2842992 0.830 rs752779 chr6:160133957 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.74 0.55 2.09e-52 Age-related macular degeneration (geographic atrophy); BRCA cis rs6484504 0.625 rs672396 chr11:31386165 A/G cg26647111 chr11:31128758 NA 0.43 9.53 0.35 3.18e-20 Red blood cell count; BRCA cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg16405210 chr4:1374714 KIAA1530 -0.92 -22.73 -0.67 3e-84 Longevity; BRCA cis rs10870270 1.000 rs7898755 chr10:133777122 G/A cg26149184 chr10:133730230 NA 0.38 7.82 0.3 2.14e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg16405210 chr4:1374714 KIAA1530 -0.58 -13.26 -0.46 1.21e-35 Longevity; BRCA cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg15605315 chr1:45957053 TESK2 0.49 9.95 0.37 9.04e-22 High light scatter reticulocyte count; BRCA cis rs17164103 0.505 rs10500136 chr7:143014244 C/T cg22531018 chr7:142981779 TMEM139 -0.72 -14.48 -0.5 2.55e-41 Cancer; BRCA cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.0 -0.34 2.53e-18 Alzheimer's disease (late onset); BRCA cis rs243505 0.762 rs10241408 chr7:148481488 G/A cg09806900 chr7:148480153 CUL1 0.52 11.0 0.4 7.09e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9814567 1.000 rs4417907 chr3:134291363 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.33 -8.07 -0.3 3.42e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg15395560 chr15:45543142 SLC28A2 0.3 8.32 0.31 5.52e-16 Uric acid levels; BRCA cis rs5167 0.504 rs7259679 chr19:45457306 C/T cg09555818 chr19:45449301 APOC2 0.46 11.94 0.43 8.27e-30 Blood protein levels; BRCA cis rs1577917 1.000 rs12213740 chr6:86656733 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.14 -0.43 1.13e-30 Response to antipsychotic treatment; BRCA cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg26031613 chr14:104095156 KLC1 0.75 16.51 0.55 2.81e-51 Body mass index; BRCA trans rs7613875 0.600 rs1138536 chr3:50153356 C/T cg21659725 chr3:3221576 CRBN 0.34 7.88 0.3 1.41e-14 Body mass index; BRCA cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg07308232 chr7:1071921 C7orf50 -0.44 -9.18 -0.34 6.09e-19 Longevity;Endometriosis; BRCA cis rs8180040 0.966 rs6800271 chr3:47470787 A/T cg16586182 chr3:47516702 SCAP 0.64 15.05 0.51 4.68e-44 Colorectal cancer; BRCA cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.17 0.74 4.21e-114 Chronic sinus infection; BRCA cis rs17401966 1.000 rs58549151 chr1:10314657 A/C cg03954927 chr1:10346856 KIF1B 0.45 12.8 0.45 1.41e-33 Hepatocellular carcinoma; BRCA trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg00717180 chr2:96193071 NA 0.3 8.25 0.31 8.96e-16 Height; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.92 -0.3 1.02e-14 Total body bone mineral density; BRCA cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg18132916 chr6:79620363 NA -0.45 -10.17 -0.37 1.25e-22 Intelligence (multi-trait analysis); BRCA cis rs4268898 0.722 rs7564420 chr2:24414002 C/T cg26838691 chr2:24397539 C2orf84 -0.39 -7.91 -0.3 1.18e-14 Asthma; BRCA cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg08999081 chr20:33150536 PIGU 0.49 14.02 0.48 4e-39 Coronary artery disease; BRCA cis rs3806843 1.000 rs2240694 chr5:140183058 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.82e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs2742234 0.541 rs11238476 chr10:43711436 G/T cg15436174 chr10:43711423 RASGEF1A 0.56 10.95 0.4 1.13e-25 Hirschsprung disease; BRCA cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg20203395 chr5:56204925 C5orf35 0.41 9.17 0.34 6.66e-19 Initial pursuit acceleration; BRCA cis rs10193935 1.000 rs13399869 chr2:42386041 C/G cg27598129 chr2:42591480 NA -0.87 -14.49 -0.5 2.26e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs495337 0.736 rs6095681 chr20:48451129 A/T cg17835207 chr20:48524531 SPATA2 0.53 12.11 0.43 1.53e-30 Psoriasis; BRCA cis rs8177179 0.904 rs1130459 chr3:133465283 A/G cg16262614 chr3:133464971 TF 0.24 7.88 0.3 1.37e-14 Iron status biomarkers (transferrin levels); BRCA cis rs4642101 0.618 rs11128614 chr3:12819212 A/G cg24848339 chr3:12840334 CAND2 0.5 13.33 0.47 6.34e-36 QRS complex (12-leadsum); BRCA cis rs4689388 0.926 rs10012946 chr4:6293350 C/T cg25554036 chr4:6271136 WFS1 -0.45 -9.96 -0.37 8.25e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2180341 0.920 rs6906717 chr6:127596782 C/A cg24812749 chr6:127587940 RNF146 0.86 20.21 0.62 1.41e-70 Breast cancer; BRCA cis rs2204008 0.720 rs11170774 chr12:38021722 C/T cg13010199 chr12:38710504 ALG10B -0.4 -8.55 -0.32 9.09e-17 Bladder cancer; BRCA cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg08807892 chr2:162101083 NA 0.72 16.47 0.55 4.43e-51 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg11707556 chr5:10655725 ANKRD33B 0.4 8.55 0.32 9.24e-17 Coronary artery disease; BRCA cis rs1448094 0.512 rs6539928 chr12:86244920 G/A cg19622623 chr12:86230825 RASSF9 -0.33 -9.28 -0.34 2.49e-19 Major depressive disorder; BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg22963979 chr7:1858916 MAD1L1 -0.4 -8.46 -0.32 1.77e-16 Bipolar disorder and schizophrenia; BRCA cis rs7020830 0.898 rs506981 chr9:37351348 A/T cg14294708 chr9:37120828 ZCCHC7 -1.0 -28.86 -0.75 7e-118 Schizophrenia; BRCA cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -8.27 -0.31 7.96e-16 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg11833968 chr6:79620685 NA -0.43 -9.6 -0.35 1.8e-20 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg21782813 chr7:2030301 MAD1L1 0.44 12.32 0.44 2e-31 Bipolar disorder and schizophrenia; BRCA cis rs11051970 0.659 rs1809913 chr12:32591626 A/G cg02745156 chr12:32552066 NA 0.27 8.15 0.31 1.96e-15 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg25214090 chr10:38739885 LOC399744 0.55 12.78 0.45 1.87e-33 Corneal astigmatism; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.43 -10.19 -0.37 1.05e-22 Lymphocyte counts; BRCA cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg23719950 chr11:63933701 MACROD1 -0.59 -9.61 -0.36 1.65e-20 Mean platelet volume; BRCA cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg21770322 chr7:97807741 LMTK2 -0.41 -10.84 -0.39 2.99e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs7945718 0.875 rs9888181 chr11:12782781 G/A cg25843174 chr11:12811716 TEAD1 0.24 9.28 0.34 2.52e-19 Educational attainment (years of education); BRCA cis rs7613875 0.600 rs2624848 chr3:50165101 T/C cg05623727 chr3:50126028 RBM5 -0.52 -12.7 -0.45 3.93e-33 Body mass index; BRCA cis rs9733 0.544 rs2867302 chr1:150653650 T/C cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Tonsillectomy; BRCA cis rs11098499 0.954 rs6838814 chr4:120392443 G/A cg09307838 chr4:120376055 NA 0.75 16.21 0.54 9.31e-50 Corneal astigmatism; BRCA cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg22974920 chr21:40686053 BRWD1 0.35 8.0 0.3 5.7e-15 Menarche (age at onset); BRCA trans rs9944715 1.000 rs8099202 chr18:43834634 G/T cg01718231 chr17:29326311 RNF135 0.4 7.89 0.3 1.31e-14 Red cell distribution width;Mean corpuscular volume; BRCA trans rs11098499 0.908 rs7696649 chr4:120322177 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.05 0.3 4.12e-15 Corneal astigmatism; BRCA cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg04450456 chr4:17643702 FAM184B 0.36 10.45 0.38 1.05e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs751728 0.687 rs9357164 chr6:33761021 T/C cg25922239 chr6:33757077 LEMD2 0.49 12.31 0.44 2.1e-31 Crohn's disease; BRCA cis rs6426558 0.559 rs485234 chr1:227317747 A/G cg10327440 chr1:227177885 CDC42BPA 0.47 9.33 0.35 1.73e-19 Neutrophil percentage of white cells; BRCA cis rs11690935 0.959 rs4668412 chr2:172619770 A/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.37 -0.77 4.35e-126 Schizophrenia; BRCA trans rs1478897 0.804 rs9329246 chr8:11392880 A/G cg06636001 chr8:8085503 FLJ10661 0.43 8.73 0.33 2.17e-17 Systemic lupus erythematosus; BRCA cis rs9473147 0.543 rs1004173 chr6:47445017 C/T cg12968598 chr6:47444699 CD2AP 0.46 9.79 0.36 3.38e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs12611088 0.571 rs2305375 chr19:44013260 C/T cg15012607 chr19:44012195 ETHE1 -0.33 -8.6 -0.32 5.93e-17 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs826838 0.967 rs1684413 chr12:39128704 G/A cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs6570726 0.791 rs1509214 chr6:145784606 A/C cg23711669 chr6:146136114 FBXO30 -0.72 -16.33 -0.54 2.24e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs7659604 0.791 rs57316471 chr4:122663939 A/G cg20573242 chr4:122745356 CCNA2 0.38 8.7 0.33 2.83e-17 Type 2 diabetes; BRCA trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg13010199 chr12:38710504 ALG10B 0.42 9.0 0.34 2.56e-18 Morning vs. evening chronotype; BRCA cis rs11098499 0.588 rs2389874 chr4:120554991 A/G cg09307838 chr4:120376055 NA -0.53 -11.02 -0.4 5.48e-26 Corneal astigmatism; BRCA cis rs875971 0.862 rs778720 chr7:65846275 A/C cg11764359 chr7:65958608 NA -0.77 -17.06 -0.56 4.76e-54 Aortic root size; BRCA cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg17063962 chr7:91808500 NA 0.53 12.51 0.44 2.79e-32 Breast cancer; BRCA cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -9.0 -0.34 2.61e-18 Aortic root size; BRCA trans rs208520 0.690 rs4710311 chr6:66823223 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -20.03 -0.62 1.27e-69 Exhaled nitric oxide output; BRCA cis rs939658 0.805 rs6495374 chr15:79434031 C/T cg17916960 chr15:79447300 NA -0.42 -10.59 -0.39 2.86e-24 Refractive error; BRCA cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs7772486 0.597 rs1970306 chr6:146154543 A/G cg23711669 chr6:146136114 FBXO30 0.74 15.93 0.53 2.41e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs12579753 0.879 rs35087297 chr12:82133398 C/T cg07988820 chr12:82153109 PPFIA2 -0.67 -11.37 -0.41 2.14e-27 Resting heart rate; BRCA cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg14829155 chr15:31115871 NA -0.43 -9.85 -0.36 2.15e-21 Huntington's disease progression; BRCA cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg02659138 chr7:134003124 SLC35B4 0.33 10.14 0.37 1.73e-22 Mean platelet volume; BRCA cis rs7640424 0.819 rs34937412 chr3:107829484 G/C cg09227934 chr3:107805635 CD47 -0.41 -8.71 -0.33 2.68e-17 Body mass index; BRCA cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg21017887 chr14:105400489 NA 0.66 17.49 0.57 2.82e-56 Rheumatoid arthritis; BRCA cis rs10752881 0.933 rs2027086 chr1:183057933 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 17.21 0.56 7.98e-55 Colorectal cancer; BRCA cis rs1949733 0.585 rs2631768 chr4:8473050 A/G cg13073564 chr4:8508604 NA 0.32 8.67 0.32 3.69e-17 Response to antineoplastic agents; BRCA cis rs9473147 0.516 rs9395286 chr6:47575332 T/C cg12968598 chr6:47444699 CD2AP 0.44 9.56 0.35 2.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs3806843 0.766 rs2530239 chr5:140062547 C/T cg16179182 chr5:140090404 VTRNA1-1 0.42 9.68 0.36 8.97e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs698833 0.828 rs3738984 chr2:44531484 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.52 -10.8 -0.39 4.35e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs8114671 0.967 rs6060285 chr20:33770487 G/T cg07148914 chr20:33460835 GGT7 0.38 8.01 0.3 5.27e-15 Height; BRCA cis rs1707322 0.896 rs946528 chr1:46485562 C/T cg06784218 chr1:46089804 CCDC17 -0.44 -10.51 -0.38 6.02e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg00750074 chr16:89608354 SPG7 -0.43 -11.62 -0.42 1.87e-28 Multiple myeloma (IgH translocation); BRCA cis rs911119 0.954 rs2405367 chr20:23622880 A/G cg16589663 chr20:23618590 CST3 -0.41 -7.84 -0.3 1.87e-14 Chronic kidney disease; BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg22920501 chr2:26401640 FAM59B -0.67 -11.56 -0.42 3.38e-28 Gut microbiome composition (summer); BRCA trans rs3733585 0.673 rs6449156 chr4:9956712 G/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.28e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2635047 0.967 rs3816125 chr18:44601611 C/T cg19077165 chr18:44547161 KATNAL2 0.44 9.0 0.34 2.6e-18 Educational attainment; BRCA cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg20644253 chr19:19431407 KIAA0892;SF4 0.5 9.96 0.37 7.85e-22 Tonsillectomy; BRCA cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.02 -0.3 4.98e-15 Extrinsic epigenetic age acceleration; BRCA cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.52 -11.38 -0.41 1.97e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs3857536 0.813 rs2040594 chr6:66943966 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.99 -0.3 6.42e-15 Blood trace element (Cu levels); BRCA trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg01191920 chr7:158217561 PTPRN2 -0.47 -11.13 -0.4 2.07e-26 Obesity-related traits; BRCA cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg03452623 chr4:187889614 NA -0.31 -10.02 -0.37 4.75e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs2777491 1.000 rs316609 chr15:41743828 T/A cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.94 -0.53 1.99e-48 Ulcerative colitis; BRCA cis rs17376456 0.825 rs55724660 chr5:93276636 A/G cg25358565 chr5:93447407 FAM172A 1.21 18.91 0.6 1.11e-63 Diabetic retinopathy; BRCA trans rs1005277 0.579 rs2474599 chr10:38438939 A/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.87 -0.48 1.9e-38 Extrinsic epigenetic age acceleration; BRCA cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -22.14 -0.66 4.72e-81 Chronic sinus infection; BRCA cis rs7833986 0.501 rs2976038 chr8:57028864 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.69 12.84 0.45 1.03e-33 Height; BRCA cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg19508488 chr2:152266495 RIF1 0.52 10.51 0.38 6.02e-24 Lung cancer; BRCA cis rs4302748 0.862 rs4723481 chr7:36180023 A/G cg24442661 chr7:36192818 EEPD1 0.45 8.63 0.32 4.88e-17 Platelet count; BRCA cis rs2153535 0.580 rs7767926 chr6:8453557 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs765787 0.530 rs4775832 chr15:45534828 A/G cg25801113 chr15:45476975 SHF 0.31 7.84 0.3 1.93e-14 Uric acid levels; BRCA cis rs2346177 0.875 rs2881327 chr2:46641955 A/G cg02822958 chr2:46747628 ATP6V1E2 0.41 8.53 0.32 1.1e-16 HDL cholesterol; BRCA cis rs2882667 0.898 rs10058347 chr5:138361358 G/A cg04439458 chr5:138467593 SIL1 -0.33 -8.84 -0.33 9.39e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg03433033 chr1:76189801 ACADM 0.75 17.23 0.56 6.15e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg11764359 chr7:65958608 NA 0.79 18.98 0.6 4.56e-64 Aortic root size; BRCA cis rs11608355 0.515 rs11611012 chr12:109945203 G/A cg05360138 chr12:110035743 NA 0.69 10.75 0.39 6.84e-25 Neuroticism; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs6831352 0.918 rs13133633 chr4:100058697 C/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs6005807 0.563 rs7288792 chr22:29015603 C/T cg12565055 chr22:29076175 TTC28 0.49 9.33 0.35 1.65e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs13217239 0.608 rs6930508 chr6:27053142 T/C cg12292205 chr6:26970375 C6orf41 -0.56 -12.39 -0.44 9.28e-32 Schizophrenia; BRCA cis rs1005277 0.579 rs2474571 chr10:38384639 T/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.96 -0.56 1.56e-53 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs2167892 chr4:99048503 G/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11252926 0.797 rs61837235 chr10:489363 G/A cg18196295 chr10:418757 DIP2C -0.52 -10.65 -0.39 1.64e-24 Psychosis in Alzheimer's disease; BRCA cis rs2421770 0.530 rs7945809 chr11:35369253 G/A cg13971030 chr11:35366721 SLC1A2 -0.43 -9.61 -0.36 1.65e-20 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs7178424 0.967 rs11635980 chr15:62370516 T/A cg00456672 chr15:62358751 C2CD4A -0.42 -9.49 -0.35 4.67e-20 Height; BRCA cis rs9560113 0.919 rs11069896 chr13:112178887 C/T cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.94e-14 Menarche (age at onset); BRCA cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.46e-19 Bipolar disorder; BRCA cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg02640540 chr1:67518911 SLC35D1 -0.51 -11.27 -0.41 5.22e-27 Lymphocyte percentage of white cells; BRCA cis rs208520 0.661 rs150263 chr6:66777620 T/C cg07460842 chr6:66804631 NA -1.02 -20.25 -0.63 8.29e-71 Exhaled nitric oxide output; BRCA cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg02544614 chr20:61657117 NA 0.28 7.9 0.3 1.21e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs7249142 0.562 rs10417796 chr19:19287072 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.47 -11.17 -0.4 1.42e-26 IgG glycosylation; BRCA cis rs6882046 0.513 rs35148765 chr5:88046158 C/A cg22951263 chr5:87985283 NA -0.38 -10.73 -0.39 7.9e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg08280861 chr8:58055591 NA 0.57 8.92 0.33 4.93e-18 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.95 -0.3 8.36e-15 Total body bone mineral density; BRCA cis rs11105298 0.891 rs6538190 chr12:89885942 T/C cg00757033 chr12:89920650 WDR51B 0.53 10.7 0.39 1.13e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs79839061 0.610 rs2279182 chr4:882625 T/G cg07828340 chr4:882639 GAK 1.05 14.37 0.49 8.71e-41 Intelligence (multi-trait analysis); BRCA cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg03060546 chr3:49711283 APEH 0.6 10.31 0.38 3.56e-23 Menarche (age at onset); BRCA cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg13628971 chr7:2884303 GNA12 0.4 8.78 0.33 1.44e-17 Height; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg04267008 chr7:1944627 MAD1L1 0.59 12.42 0.44 7.36e-32 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg23992470 chr4:843637 GAK 0.49 8.16 0.31 1.72e-15 Intelligence (multi-trait analysis); BRCA cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg17892150 chr10:133769511 PPP2R2D -0.73 -15.63 -0.53 6.99e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2276314 0.857 rs3737474 chr18:33613595 T/C cg19628046 chr18:33552617 C18orf21 0.55 10.73 0.39 7.94e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.61 -13.1 -0.46 6.7e-35 Lymphocyte counts; BRCA trans rs7615952 0.609 rs13088451 chr3:125553499 G/C cg07211511 chr3:129823064 LOC729375 -0.82 -15.38 -0.52 1.23e-45 Blood pressure (smoking interaction); BRCA cis rs10501293 0.662 rs7929773 chr11:42999551 C/G cg03447554 chr11:43094025 NA -0.41 -7.88 -0.3 1.39e-14 Cognitive performance; BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.9 -0.33 5.54e-18 Total body bone mineral density; BRCA cis rs7786808 0.741 rs62479982 chr7:158227546 A/G cg09998033 chr7:158218633 PTPRN2 -0.41 -9.66 -0.36 1.07e-20 Obesity-related traits; BRCA cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 7.99 0.3 6.27e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3857536 0.740 rs4710572 chr6:66890361 C/A cg07460842 chr6:66804631 NA -0.46 -8.85 -0.33 8.46e-18 Blood trace element (Cu levels); BRCA cis rs7903847 0.667 rs7096801 chr10:99140969 T/C cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs35110281 0.714 rs7277539 chr21:45053011 A/G cg01579765 chr21:45077557 HSF2BP -0.42 -11.2 -0.41 1.02e-26 Mean corpuscular volume; BRCA trans rs12310956 0.532 rs7955514 chr12:33978737 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.43 0.35 7.69e-20 Morning vs. evening chronotype; BRCA cis rs1707322 0.647 rs6686944 chr1:46156308 G/T cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.96e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs910316 0.967 rs175505 chr14:75529619 C/T cg11812906 chr14:75593930 NEK9 -0.61 -14.04 -0.49 3.14e-39 Height; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs13161895 1.000 rs35973843 chr5:179466502 T/C cg02702477 chr5:179499311 RNF130 0.46 8.53 0.32 1.03e-16 LDL cholesterol; BRCA cis rs826838 0.904 rs11612004 chr12:39204282 G/A cg26384229 chr12:38710491 ALG10B 0.8 19.69 0.61 7.9e-68 Heart rate; BRCA cis rs10501293 0.917 rs9645617 chr11:43105620 G/A cg03447554 chr11:43094025 NA -0.45 -8.49 -0.32 1.49e-16 Cognitive performance; BRCA cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14298792 chr15:30685198 CHRFAM7A 0.43 8.63 0.32 4.86e-17 Huntington's disease progression; BRCA cis rs709400 0.628 rs10141120 chr14:103923008 T/C cg26031613 chr14:104095156 KLC1 0.73 15.89 0.53 3.64e-48 Body mass index; BRCA cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg16339924 chr4:17578868 LAP3 -0.57 -13.27 -0.46 1.09e-35 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs561341 1.000 rs554078 chr17:30330109 A/C cg12193833 chr17:30244370 NA -0.58 -8.74 -0.33 2.11e-17 Hip circumference adjusted for BMI; BRCA cis rs2635047 0.837 rs2571009 chr18:44650279 A/G cg19077165 chr18:44547161 KATNAL2 -0.38 -8.27 -0.31 7.83e-16 Educational attainment; BRCA cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg12573674 chr2:1569213 NA -0.51 -9.48 -0.35 4.98e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11644478 chr21:40555479 PSMG1 -0.67 -15.22 -0.52 7.43e-45 Cognitive function; BRCA cis rs875971 0.545 rs2460427 chr7:65619205 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.95 -0.37 8.93e-22 Aortic root size; BRCA cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg08859206 chr1:53392774 SCP2 -0.52 -11.34 -0.41 2.72e-27 Monocyte count; BRCA cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1003719 0.762 rs9975361 chr21:38450025 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.28e-40 Eye color traits; BRCA cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg03146154 chr1:46216737 IPP 0.48 10.66 0.39 1.52e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs933688 1.000 rs332529 chr5:90789470 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 14.83 0.51 5.53e-43 Smoking behavior; BRCA cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.08 0.58 2.44e-59 Age-related macular degeneration (geographic atrophy); BRCA cis rs9394841 0.667 rs9471653 chr6:41755410 C/G cg08135965 chr6:41755394 TOMM6 0.5 8.1 0.31 2.87e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.07 0.3 3.52e-15 Tonsillectomy; BRCA trans rs35110281 0.714 rs7277539 chr21:45053011 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.3 0.38 3.91e-23 Mean corpuscular volume; BRCA cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg06022373 chr22:39101656 GTPBP1 0.74 16.95 0.56 1.62e-53 Menopause (age at onset); BRCA cis rs11719291 0.915 rs9834996 chr3:48754877 G/T cg01304814 chr3:48885189 PRKAR2A 0.56 7.82 0.3 2.25e-14 Cognitive function; BRCA cis rs12220238 1.000 rs10824125 chr10:75997498 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.49 8.0 0.3 5.7e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs7666738 0.791 rs11097601 chr4:98960103 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg01283332 chr5:1856932 NA -0.37 -8.9 -0.33 5.7e-18 Cardiovascular disease risk factors; BRCA cis rs11690935 0.851 rs7581072 chr2:172859849 C/T cg13550731 chr2:172543902 DYNC1I2 -0.79 -22.99 -0.67 1.04e-85 Schizophrenia; BRCA trans rs11098499 0.874 rs13139045 chr4:120168588 T/C cg25214090 chr10:38739885 LOC399744 0.45 9.99 0.37 6.45e-22 Corneal astigmatism; BRCA cis rs2346177 0.542 rs6718875 chr2:46687982 G/T cg02822958 chr2:46747628 ATP6V1E2 0.56 10.66 0.39 1.52e-24 HDL cholesterol; BRCA cis rs9814567 1.000 rs6766897 chr3:134191303 C/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.57 -17.7 -0.57 2.38e-57 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs34779708 0.733 rs7086715 chr10:35541840 A/G cg03585969 chr10:35415529 CREM 0.45 9.18 0.34 5.96e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4466137 0.953 rs7735476 chr5:83015140 G/C cg15083037 chr5:83017644 HAPLN1 -0.55 -10.95 -0.4 1.09e-25 Prostate cancer; BRCA cis rs4478858 0.684 rs7521463 chr1:31761936 T/A cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs3857067 0.806 rs7669168 chr4:95104881 G/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.24 -0.34 3.55e-19 QT interval; BRCA trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg15704280 chr7:45808275 SEPT13 0.52 8.85 0.33 8.42e-18 Axial length; BRCA trans rs7395662 0.819 rs11039913 chr11:48692081 G/A cg00717180 chr2:96193071 NA -0.28 -7.9 -0.3 1.26e-14 HDL cholesterol; BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.37 -8.81 -0.33 1.2e-17 Tonsillectomy; BRCA trans rs2204008 0.640 rs2320744 chr12:38162389 A/G cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs2204008 0.715 rs3899385 chr12:38169880 C/G cg26384229 chr12:38710491 ALG10B 0.7 15.83 0.53 7.18e-48 Bladder cancer; BRCA cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.49e-15 Tonsillectomy; BRCA cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 13.59 0.47 3.9e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs798554 0.591 rs757791 chr7:2867296 A/G cg19717773 chr7:2847554 GNA12 -0.45 -9.83 -0.36 2.38e-21 Height; BRCA cis rs61160187 0.503 rs248911 chr5:59847538 T/C cg02684056 chr5:59996105 DEPDC1B 0.35 8.46 0.32 1.76e-16 Educational attainment (years of education);Educational attainment (college completion); BRCA trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg13010199 chr12:38710504 ALG10B -0.43 -9.14 -0.34 8.43e-19 Morning vs. evening chronotype; BRCA cis rs826838 0.806 rs826873 chr12:39121305 G/A cg13010199 chr12:38710504 ALG10B -0.43 -10.06 -0.37 3.39e-22 Heart rate; BRCA cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.39 8.88 0.33 6.64e-18 Eosinophil percentage of white cells; BRCA cis rs9467773 0.967 rs9467775 chr6:26513435 G/A cg09904177 chr6:26538194 HMGN4 0.56 18.45 0.59 3.08e-61 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.560 rs1450521 chr3:161091237 C/A cg03342759 chr3:160939853 NMD3 -0.56 -11.93 -0.43 9.38e-30 Morning vs. evening chronotype; BRCA cis rs9311474 0.508 rs3796353 chr3:52593230 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.5 0.44 3.09e-32 Electroencephalogram traits; BRCA trans rs1994135 0.715 rs11052742 chr12:33692290 A/C cg26384229 chr12:38710491 ALG10B 0.4 8.6 0.32 6.3e-17 Resting heart rate; BRCA cis rs1018836 0.923 rs9693182 chr8:91621876 T/C cg16814680 chr8:91681699 NA -0.6 -12.8 -0.45 1.46e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 0.731 rs6846966 chr4:120293208 A/G cg25214090 chr10:38739885 LOC399744 0.5 11.62 0.42 1.85e-28 Corneal astigmatism; BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg05793240 chr7:2802953 GNA12 -0.33 -8.58 -0.32 7.06e-17 Height; BRCA cis rs965469 0.895 rs6051839 chr20:3391191 C/T cg25506879 chr20:3388711 C20orf194 0.54 10.71 0.39 1e-24 IFN-related cytopenia; BRCA cis rs9287719 0.624 rs10187659 chr2:10726960 C/T cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs11098499 0.866 rs12513310 chr4:120288039 T/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs778371 0.958 rs2675968 chr2:233736244 A/G cg08000102 chr2:233561755 GIGYF2 0.77 17.17 0.56 1.27e-54 Schizophrenia; BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg11814155 chr7:99998594 ZCWPW1 0.49 8.85 0.33 8.6e-18 Platelet count; BRCA cis rs2243480 1.000 rs12698509 chr7:65418876 C/T cg18252515 chr7:66147081 NA -0.82 -11.96 -0.43 7e-30 Diabetic kidney disease; BRCA cis rs6426558 0.537 rs10799381 chr1:227239746 G/T cg10327440 chr1:227177885 CDC42BPA 0.49 9.71 0.36 6.74e-21 Neutrophil percentage of white cells; BRCA cis rs6964587 0.967 rs9656003 chr7:91766322 A/C cg17063962 chr7:91808500 NA 0.61 14.46 0.5 3.48e-41 Breast cancer; BRCA cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg26446133 chr18:72167187 CNDP2 -0.73 -12.98 -0.46 2.35e-34 Refractive error; BRCA cis rs3857536 0.704 rs4710570 chr6:66890244 A/G cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.01e-18 Blood trace element (Cu levels); BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg14863265 chr7:2801509 GNA12 -0.43 -9.31 -0.35 1.96e-19 Height; BRCA cis rs9790314 1.000 rs336569 chr3:161072346 T/G cg03342759 chr3:160939853 NMD3 -0.54 -11.72 -0.42 7.11e-29 Morning vs. evening chronotype; BRCA trans rs11098499 0.863 rs2170276 chr4:120485824 A/C cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs853679 0.517 rs1947862 chr6:28105196 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.17 -0.31 1.67e-15 Depression; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg18402987 chr7:1209562 NA 0.72 12.6 0.45 1.16e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg03433033 chr1:76189801 ACADM 0.62 11.52 0.41 5.05e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.806 rs6435040 chr2:200861161 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.67 10.46 0.38 9.82e-24 Schizophrenia; BRCA cis rs11098499 0.754 rs7672778 chr4:120248585 A/G cg09307838 chr4:120376055 NA 0.64 14.0 0.48 4.78e-39 Corneal astigmatism; BRCA cis rs12586317 0.620 rs28404080 chr14:35539418 G/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.32 -0.38 3.48e-23 Psoriasis; BRCA cis rs7635838 0.654 rs164101 chr3:11281082 G/A cg00170343 chr3:11313890 ATG7 0.45 8.67 0.32 3.51e-17 HDL cholesterol; BRCA cis rs9291683 0.609 rs55959894 chr4:10026580 G/A cg00071950 chr4:10020882 SLC2A9 0.65 16.37 0.54 1.48e-50 Bone mineral density; BRCA cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs2992756 0.663 rs1360919 chr1:18805844 T/C cg14356550 chr1:18808102 KLHDC7A -0.41 -8.39 -0.32 3.03e-16 Breast cancer; BRCA cis rs17270561 0.636 rs6923839 chr6:25745853 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.81e-17 Iron status biomarkers; BRCA cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.45 -0.38 1.06e-23 Reticulocyte count; BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 14.77 0.5 1.09e-42 Platelet count; BRCA cis rs6570726 0.791 rs7755253 chr6:145858893 C/G cg23711669 chr6:146136114 FBXO30 0.79 18.97 0.6 5.75e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.59 12.35 0.44 1.39e-31 Hip circumference adjusted for BMI; BRCA trans rs2270927 0.510 rs6453213 chr5:75579518 A/G cg13563193 chr19:33072644 PDCD5 0.88 11.25 0.41 6.55e-27 Mean corpuscular volume; BRCA cis rs2070433 0.539 rs1008548 chr21:47959692 G/A cg12379764 chr21:47803548 PCNT 0.59 12.08 0.43 2.15e-30 Lymphocyte counts; BRCA cis rs1865760 0.929 rs9467646 chr6:25957408 A/G cg16482183 chr6:26056742 HIST1H1C 0.52 10.89 0.4 1.95e-25 Height; BRCA cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.9 -0.33 5.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.754 rs2328709 chr6:146106819 A/G cg13319975 chr6:146136371 FBXO30 0.43 10.13 0.37 1.8e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs8072100 0.840 rs12453233 chr17:45454570 C/T cg08085267 chr17:45401833 C17orf57 -0.69 -15.2 -0.52 9.32e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.77 0.39 5.6e-25 Bipolar disorder; BRCA cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.07 -0.4 3.38e-26 Schizophrenia; BRCA cis rs6545883 0.868 rs2441381 chr2:61798829 C/T cg15711740 chr2:61764176 XPO1 -0.54 -13.45 -0.47 1.64e-36 Tuberculosis; BRCA cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg13319975 chr6:146136371 FBXO30 -0.34 -8.03 -0.3 4.85e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg15704280 chr7:45808275 SEPT13 0.52 8.91 0.33 5.21e-18 Axial length; BRCA cis rs13064411 0.696 rs7610638 chr3:113139656 A/G cg18753928 chr3:113234510 CCDC52 -0.5 -9.42 -0.35 8.42e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs4285028 0.747 rs7648340 chr3:121426188 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.97 -0.48 6.66e-39 Multiple sclerosis; BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.19 0.34 5.39e-19 Tonsillectomy; BRCA cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg22105103 chr4:187893119 NA 0.34 11.01 0.4 5.96e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg06115741 chr20:33292138 TP53INP2 0.36 8.29 0.31 6.45e-16 Glomerular filtration rate (creatinine); BRCA cis rs965469 1.000 rs2236092 chr20:3258188 G/C cg25506879 chr20:3388711 C20orf194 -0.55 -10.79 -0.39 4.55e-25 IFN-related cytopenia; BRCA cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg05868516 chr6:26286170 HIST1H4H 0.5 11.25 0.41 6.6e-27 Educational attainment; BRCA cis rs9325144 0.534 rs1843887 chr12:38692380 T/C cg26384229 chr12:38710491 ALG10B 0.51 13.55 0.47 5.99e-37 Morning vs. evening chronotype; BRCA cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg05279229 chr7:1896384 MAD1L1 -0.4 -7.98 -0.3 6.89e-15 Schizophrenia; BRCA trans rs1997103 0.911 rs10238738 chr7:55412359 T/C cg20935933 chr6:143382018 AIG1 0.6 11.57 0.42 3.18e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs11088226 0.681 rs4547609 chr21:33953542 G/A cg09050820 chr6:167586206 TCP10L2 0.86 14.75 0.5 1.41e-42 Gastritis; BRCA cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg16506815 chr2:162101123 NA 0.41 8.64 0.32 4.55e-17 Intelligence (multi-trait analysis); BRCA cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.61 13.86 0.48 2.1e-38 Multiple sclerosis; BRCA cis rs9325144 0.555 rs1843867 chr12:38703855 A/G cg13010199 chr12:38710504 ALG10B -0.35 -8.41 -0.32 2.64e-16 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs9356986 chr6:25739119 T/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.81e-18 Iron status biomarkers; BRCA cis rs17767294 0.708 rs72848754 chr6:27878458 T/A cg08851530 chr6:28072375 NA 0.92 8.91 0.33 5.15e-18 Parkinson's disease; BRCA cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg17143192 chr8:8559678 CLDN23 0.54 10.38 0.38 1.95e-23 Obesity-related traits; BRCA cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg03264133 chr6:25882463 NA -0.55 -12.86 -0.45 7.7e-34 Blood metabolite levels; BRCA cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs1042058 0.565 rs650110 chr10:30753132 A/G cg18806716 chr10:30721971 MAP3K8 -0.42 -10.09 -0.37 2.53e-22 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs11792861 0.926 rs1044905 chr9:111781495 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.05 0.3 4e-15 Menarche (age at onset); BRCA cis rs801193 0.569 rs2659908 chr7:66160822 G/A cg18876405 chr7:65276391 NA 0.48 10.77 0.39 5.54e-25 Aortic root size; BRCA cis rs12579753 0.917 rs10862361 chr12:82197946 T/C cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs262150 1.000 rs262150 chr7:158777934 G/A cg09640425 chr7:158790006 NA -0.37 -7.81 -0.3 2.34e-14 Facial morphology (factor 20); BRCA cis rs10501293 0.956 rs12361827 chr11:43137261 T/C cg03447554 chr11:43094025 NA -0.46 -8.05 -0.3 4.16e-15 Cognitive performance; BRCA cis rs17384381 0.953 rs12120551 chr1:85810903 T/C cg16011679 chr1:85725395 C1orf52 0.53 7.99 0.3 6.48e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.698 rs6429599 chr1:46827871 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -9.4 -0.35 9.47e-20 Menopause (age at onset); BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg00024416 chr22:24240387 NA -0.33 -8.24 -0.31 9.87e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7809950 0.953 rs2253271 chr7:107201252 G/C cg23024343 chr7:107201750 COG5 -0.38 -8.82 -0.33 1.11e-17 Coronary artery disease; BRCA cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg20503657 chr10:835505 NA 0.86 15.72 0.53 2.53e-47 Eosinophil percentage of granulocytes; BRCA trans rs61931739 0.500 rs11519123 chr12:34436478 A/G cg26384229 chr12:38710491 ALG10B 0.58 13.16 0.46 3.41e-35 Morning vs. evening chronotype; BRCA cis rs7917772 0.604 rs11191358 chr10:104399250 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -10.18 -0.37 1.18e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9287719 0.639 rs2357649 chr2:10696788 C/T cg00105475 chr2:10696890 NA -0.54 -13.32 -0.47 6.72e-36 Prostate cancer; BRCA cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg26248373 chr2:1572462 NA -0.47 -9.29 -0.34 2.48e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2387326 0.717 rs10829340 chr10:129943941 G/T cg16087940 chr10:129947807 NA -0.45 -8.01 -0.3 5.47e-15 Select biomarker traits; BRCA trans rs60843830 0.550 rs300751 chr2:209063 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.39 8.42 0.32 2.41e-16 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg17366294 chr4:99064904 C4orf37 0.54 11.67 0.42 1.15e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs2276314 0.600 rs28729782 chr18:33590529 A/G cg05985134 chr18:33552581 C18orf21 0.42 7.88 0.3 1.38e-14 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7707921 0.881 rs112355050 chr5:81386035 C/T cg15871215 chr5:81402204 ATG10 -0.39 -8.22 -0.31 1.17e-15 Breast cancer; BRCA cis rs3806843 0.750 rs2563285 chr5:140126137 T/C cg11822812 chr5:140052017 DND1 -0.31 -8.4 -0.32 2.85e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs6867032 1.000 rs4254943 chr5:2009878 C/T cg26168224 chr5:2018326 NA 0.63 16.88 0.56 3.83e-53 Gut microbiome composition (winter); BRCA cis rs6546550 0.901 rs6716937 chr2:70127229 G/A cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.89e-28 Prevalent atrial fibrillation; BRCA cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg18876405 chr7:65276391 NA -0.5 -11.04 -0.4 4.78e-26 Aortic root size; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg02951883 chr7:2050386 MAD1L1 0.51 11.56 0.42 3.23e-28 Bipolar disorder and schizophrenia; BRCA cis rs796364 0.589 rs6743217 chr2:201134914 G/A cg23649088 chr2:200775458 C2orf69 -0.48 -8.06 -0.3 3.74e-15 Schizophrenia; BRCA cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.76 0.36 4.52e-21 Menopause (age at onset); BRCA cis rs11622475 1.000 rs7143682 chr14:104413455 C/T cg12183467 chr14:104352244 NA -0.52 -10.76 -0.39 6.39e-25 Bipolar disorder; BRCA cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.03 0.43 3.38e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7131987 0.834 rs11050167 chr12:29426387 C/T cg09582351 chr12:29534625 ERGIC2 -0.5 -11.31 -0.41 3.63e-27 QT interval; BRCA trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg15556689 chr8:8085844 FLJ10661 0.4 10.64 0.39 1.86e-24 Retinal vascular caliber; BRCA cis rs6495367 0.898 rs2049176 chr15:79392548 A/C cg17916960 chr15:79447300 NA 0.39 9.38 0.35 1.18e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6580649 0.943 rs1990029 chr12:48407987 C/T cg24011408 chr12:48396354 COL2A1 0.53 8.65 0.32 4.18e-17 Lung cancer; BRCA cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg26384229 chr12:38710491 ALG10B 0.74 17.02 0.56 7.3e-54 Bladder cancer; BRCA cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg05313129 chr8:58192883 C8orf71 -0.36 -8.11 -0.31 2.67e-15 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs2592113 chr2:233669553 C/T cg08000102 chr2:233561755 GIGYF2 0.62 13.66 0.48 1.78e-37 Coronary artery disease; BRCA cis rs2279817 0.818 rs867984 chr1:17982559 G/A cg21791023 chr1:18019539 ARHGEF10L -0.49 -11.23 -0.41 8.05e-27 Neuroticism; BRCA cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg13319975 chr6:146136371 FBXO30 0.42 9.47 0.35 5.14e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.71 -0.57 2.04e-57 Chronic sinus infection; BRCA cis rs754466 0.651 rs10824582 chr10:79603688 T/C cg17075019 chr10:79541650 NA -0.74 -17.7 -0.57 2.44e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg25517755 chr10:38738941 LOC399744 -0.37 -7.86 -0.3 1.66e-14 Corneal astigmatism; BRCA cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg23933602 chr10:16859644 RSU1 0.54 8.62 0.32 5.13e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs875971 0.545 rs6969224 chr7:65834998 T/G cg11764359 chr7:65958608 NA 0.64 10.9 0.4 1.8e-25 Aortic root size; BRCA cis rs2439831 0.850 rs3862142 chr15:44064806 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.87 0.43 1.61e-29 Lung cancer in ever smokers; BRCA cis rs5753618 0.583 rs5753639 chr22:31870400 A/G cg02404636 chr22:31891804 SFI1 -0.41 -9.25 -0.34 3.39e-19 Colorectal cancer; BRCA cis rs6847149 0.929 rs6839680 chr4:110765496 A/G cg07850274 chr4:110748770 RRH -0.44 -8.59 -0.32 6.86e-17 Exercise treadmill test traits; BRCA cis rs6860806 0.507 rs273915 chr5:131660119 G/C cg12564285 chr5:131593104 PDLIM4 0.34 7.9 0.3 1.22e-14 Breast cancer; BRCA cis rs897080 0.515 rs1067398 chr2:44678882 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.53 0.35 3.35e-20 Height; BRCA cis rs6121246 0.559 rs1062794 chr20:30381758 G/C cg21427119 chr20:30132790 HM13 -0.34 -7.82 -0.3 2.19e-14 Mean corpuscular hemoglobin; BRCA cis rs6964587 0.610 rs2888850 chr7:91430027 T/C cg17063962 chr7:91808500 NA 0.53 12.11 0.43 1.56e-30 Breast cancer; BRCA cis rs1862618 0.853 rs2548665 chr5:56131805 T/A cg20203395 chr5:56204925 C5orf35 -0.49 -10.12 -0.37 2.06e-22 Initial pursuit acceleration; BRCA cis rs2731664 0.792 rs1130857 chr5:176863519 G/C cg23176889 chr5:176863531 GRK6 -0.61 -16.6 -0.55 1.04e-51 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg17971929 chr21:40555470 PSMG1 0.8 18.6 0.59 4.88e-62 Cognitive function; BRCA cis rs3858526 0.523 rs10838749 chr11:5884246 A/G cg13902645 chr11:5959945 NA -0.48 -10.15 -0.37 1.59e-22 DNA methylation (variation); BRCA cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg07606381 chr6:8435919 SLC35B3 0.64 14.08 0.49 2.02e-39 Motion sickness; BRCA cis rs4148883 0.504 rs4585310 chr4:100120233 T/C cg13256891 chr4:100009986 ADH5 -0.39 -9.24 -0.34 3.48e-19 Alcohol dependence; BRCA cis rs9486719 1.000 rs11153058 chr6:97012746 C/T cg06623918 chr6:96969491 KIAA0776 -0.76 -13.71 -0.48 1.11e-37 Migraine;Coronary artery disease; BRCA cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.4e-77 Mean platelet volume; BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg09060608 chr5:178986726 RUFY1 -0.55 -14.03 -0.49 3.52e-39 Lung cancer; BRCA cis rs4689592 0.554 rs66925245 chr4:7071999 C/T cg26116260 chr4:7069785 GRPEL1 -0.89 -19.09 -0.6 1.19e-64 Monocyte percentage of white cells; BRCA cis rs3796619 0.503 rs13147452 chr4:1078124 G/A cg27284194 chr4:1044797 NA 0.69 15.96 0.53 1.66e-48 Recombination rate (males); BRCA cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.13 0.34 8.92e-19 Systemic lupus erythematosus; BRCA cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.77 -0.5 1.05e-42 Initial pursuit acceleration; BRCA cis rs372883 0.554 rs10154065 chr21:30749480 G/C cg24692254 chr21:30365293 RNF160 0.47 10.47 0.38 9.11e-24 Pancreatic cancer; BRCA cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg12310025 chr6:25882481 NA -0.55 -13.08 -0.46 8.48e-35 Blood metabolite levels; BRCA cis rs1707322 0.752 rs6662164 chr1:46146230 T/A cg06784218 chr1:46089804 CCDC17 0.45 10.67 0.39 1.38e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35306767 0.903 rs10508208 chr10:910983 C/T cg26597838 chr10:835615 NA 1.0 17.7 0.57 2.54e-57 Eosinophil percentage of granulocytes; BRCA cis rs1997103 1.000 rs11238364 chr7:55407632 G/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4853036 0.951 rs6738783 chr2:70120608 A/G cg02498382 chr2:70120550 SNRNP27 -0.56 -10.16 -0.37 1.4e-22 Colorectal or endometrial cancer; BRCA cis rs7267979 0.934 rs2257464 chr20:25265872 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.78e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11955398 0.585 rs4447941 chr5:60022211 A/G cg02684056 chr5:59996105 DEPDC1B -0.38 -9.13 -0.34 8.56e-19 Intelligence (multi-trait analysis); BRCA cis rs6456156 0.586 rs6456149 chr6:167463902 T/C cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.79e-21 Primary biliary cholangitis; BRCA cis rs4363385 0.747 rs946098 chr1:152975038 A/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.07 -0.34 1.48e-18 Inflammatory skin disease; BRCA cis rs9381040 0.610 rs9367094 chr6:41017860 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.0 -0.34 2.53e-18 Alzheimer's disease (late onset); BRCA cis rs6750047 0.747 rs2116229 chr2:38270490 G/T cg07380506 chr2:38303506 CYP1B1 0.43 9.65 0.36 1.16e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.43e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs4561483 0.801 rs33640 chr16:11986874 C/T cg08843971 chr16:11963173 GSPT1 -0.53 -12.06 -0.43 2.5e-30 Testicular germ cell tumor; BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg08888203 chr3:10149979 C3orf24 0.6 12.32 0.44 1.92e-31 Alzheimer's disease; BRCA cis rs6604026 0.671 rs6697543 chr1:93312295 C/A cg17283838 chr1:93427260 FAM69A -0.39 -8.14 -0.31 2.07e-15 Multiple sclerosis; BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg10862848 chr6:42927986 GNMT 0.38 15.57 0.52 1.4e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7086627 0.515 rs2125040 chr10:82208422 G/C cg00277334 chr10:82204260 NA -0.85 -24.58 -0.7 2.14e-94 Post bronchodilator FEV1; BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg13880726 chr7:1868755 MAD1L1 0.53 10.48 0.38 8.16e-24 Bipolar disorder and schizophrenia; BRCA cis rs4642101 0.662 rs9840766 chr3:12821870 G/A cg24848339 chr3:12840334 CAND2 0.48 12.7 0.45 4.22e-33 QRS complex (12-leadsum); BRCA cis rs490234 0.812 rs10121109 chr9:128455206 C/A cg14078157 chr9:128172775 NA -0.43 -9.68 -0.36 9.03e-21 Mean arterial pressure; BRCA cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs9400271 0.632 rs9372205 chr6:109588401 A/T cg21918786 chr6:109611834 NA -0.32 -8.1 -0.31 2.73e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.6 -0.32 6.38e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg03354898 chr7:1950403 MAD1L1 -0.39 -8.44 -0.32 2.07e-16 Schizophrenia; BRCA cis rs7829975 0.686 rs907180 chr8:8702827 A/G cg15556689 chr8:8085844 FLJ10661 0.38 10.7 0.39 1.11e-24 Mood instability; BRCA cis rs7264396 0.790 rs2425160 chr20:34425968 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.87 -0.51 3.65e-43 Total cholesterol levels; BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg12564285 chr5:131593104 PDLIM4 0.43 11.04 0.4 4.77e-26 Acylcarnitine levels; BRCA cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg18132916 chr6:79620363 NA -0.39 -7.83 -0.3 2.07e-14 Intelligence (multi-trait analysis); BRCA cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs208520 1.000 rs208520 chr6:66952828 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -13.59 -0.47 3.96e-37 Exhaled nitric oxide output; BRCA trans rs7824557 0.606 rs2736264 chr8:11186639 G/C cg15556689 chr8:8085844 FLJ10661 0.34 9.11 0.34 1.04e-18 Retinal vascular caliber; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg05552183 chr6:42928497 GNMT 0.8 19.52 0.61 6.96e-67 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2073300 0.609 rs6137913 chr20:23357725 C/T cg12062639 chr20:23401060 NAPB 0.8 11.49 0.41 6.31e-28 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9814567 0.806 rs6799543 chr3:134216139 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.41 -0.32 2.72e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg06238570 chr21:40685208 BRWD1 0.44 9.0 0.34 2.62e-18 Cognitive function; BRCA cis rs56104184 0.775 rs73061689 chr19:49397214 C/T cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.71 -0.36 7.17e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs3849570 1.000 rs13088000 chr3:81839404 T/C cg07356753 chr3:81810745 GBE1 -0.48 -11.52 -0.41 4.74e-28 Waist circumference;Body mass index; BRCA trans rs6076960 0.682 rs6054065 chr20:6267920 G/A cg21095983 chr6:86352623 SYNCRIP 0.37 8.37 0.31 3.56e-16 Smooth-surface caries; BRCA cis rs2882667 0.654 rs884470 chr5:138155925 A/G cg04439458 chr5:138467593 SIL1 0.32 8.09 0.3 3.06e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs72772090 0.539 rs72773932 chr5:96118148 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs921968 0.541 rs562510 chr2:219443001 A/C cg10223061 chr2:219282414 VIL1 -0.27 -8.1 -0.31 2.71e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs6005807 0.719 rs12167434 chr22:29040821 C/T cg12565055 chr22:29076175 TTC28 0.5 9.36 0.35 1.32e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26314531 chr2:26401878 FAM59B -0.89 -15.65 -0.53 5.44e-47 Gut microbiome composition (summer); BRCA cis rs11123610 0.520 rs59726279 chr2:3718655 A/G cg19052272 chr2:3704530 ALLC -0.45 -10.09 -0.37 2.64e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg04553112 chr3:125709451 NA -0.55 -8.44 -0.32 2.1e-16 Blood pressure (smoking interaction); BRCA cis rs1580019 0.885 rs3801331 chr7:32497039 A/G cg06627557 chr7:32535165 LSM5;AVL9 -0.86 -18.97 -0.6 5.27e-64 Cognitive ability; BRCA cis rs7851660 1.000 rs7851660 chr9:100610759 C/A cg13688889 chr9:100608707 NA -0.36 -8.69 -0.32 3.12e-17 Strep throat; BRCA cis rs6121246 0.697 rs7269866 chr20:30232504 G/A cg21427119 chr20:30132790 HM13 -0.44 -9.12 -0.34 9.32e-19 Mean corpuscular hemoglobin; BRCA cis rs6087990 0.806 rs910084 chr20:31379665 C/T cg13636640 chr20:31349939 DNMT3B 0.58 17.36 0.57 1.35e-55 Ulcerative colitis; BRCA trans rs208515 0.525 rs12193560 chr6:66690457 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.05 0.54 5.75e-49 Exhaled nitric oxide levels; BRCA cis rs896854 0.738 rs509594 chr8:95967156 C/G cg16049864 chr8:95962084 TP53INP1 0.48 10.68 0.39 1.33e-24 Type 2 diabetes; BRCA cis rs795544 0.580 rs7709692 chr5:13789420 T/C cg07548982 chr5:13769939 DNAH5 -0.4 -8.41 -0.32 2.62e-16 Corneal astigmatism; BRCA cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg27478167 chr7:817139 HEATR2 -0.44 -9.41 -0.35 8.63e-20 Cerebrospinal P-tau181p levels; BRCA cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg15839431 chr19:19639596 YJEFN3 0.35 8.19 0.31 1.42e-15 Bipolar disorder; BRCA cis rs4742903 0.509 rs10991124 chr9:106917475 A/T cg14250997 chr9:106856677 SMC2 0.27 8.17 0.31 1.64e-15 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs11719291 0.915 rs11557629 chr3:48732223 G/A cg00383909 chr3:49044727 WDR6 0.58 11.06 0.4 4.06e-26 Cognitive function; BRCA cis rs877282 0.533 rs10904565 chr10:819991 G/T cg15764593 chr10:829463 NA -0.63 -10.29 -0.38 4.47e-23 Uric acid levels; BRCA cis rs2014572 0.967 rs7248000 chr19:57762139 C/T cg24459738 chr19:57751996 ZNF805 -0.38 -8.86 -0.33 7.95e-18 Hyperactive-impulsive symptoms; BRCA cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg05985134 chr18:33552581 C18orf21 0.65 11.68 0.42 1.01e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6495367 0.966 rs745029 chr15:79381779 C/T cg17916960 chr15:79447300 NA 0.38 8.95 0.33 3.86e-18 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs61931739 0.534 rs11052979 chr12:34035774 G/T cg13010199 chr12:38710504 ALG10B 0.49 9.51 0.35 3.84e-20 Morning vs. evening chronotype; BRCA cis rs7818345 1.000 rs7835461 chr8:19307051 C/T cg11303988 chr8:19266685 CSGALNACT1 0.31 8.07 0.3 3.58e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg22509189 chr2:225307070 NA -0.46 -9.91 -0.37 1.21e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs4268898 0.722 rs2288072 chr2:24390517 G/A cg06627628 chr2:24431161 ITSN2 0.41 8.45 0.32 1.93e-16 Asthma; BRCA cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.78e-19 Menopause (age at onset); BRCA trans rs11039798 0.588 rs12284168 chr11:48555627 C/T cg15704280 chr7:45808275 SEPT13 0.53 8.97 0.33 3.33e-18 Axial length; BRCA cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg18402987 chr7:1209562 NA 0.43 8.17 0.31 1.65e-15 Longevity;Endometriosis; BRCA cis rs7267979 1.000 rs2387880 chr20:25377787 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.13 -0.34 9.13e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg23696834 chr6:42928345 GNMT -0.26 -7.86 -0.3 1.65e-14 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4727443 0.899 rs6954978 chr7:99582212 A/G cg22004693 chr7:99632812 ZKSCAN1 0.37 8.31 0.31 5.67e-16 Interstitial lung disease; BRCA cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -16.07 -0.54 4.42e-49 Axial length; BRCA cis rs2387326 0.717 rs10829343 chr10:129944496 T/C cg16087940 chr10:129947807 NA -0.46 -8.1 -0.31 2.82e-15 Select biomarker traits; BRCA cis rs360798 0.512 rs6739804 chr2:63269604 T/C cg17519650 chr2:63277830 OTX1 0.47 10.47 0.38 8.94e-24 Coronary artery disease; BRCA cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg06060754 chr5:176797920 RGS14 0.79 14.16 0.49 8.75e-40 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs1707322 0.686 rs11211179 chr1:46228082 A/C cg03146154 chr1:46216737 IPP 0.46 10.32 0.38 3.49e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg24642844 chr7:1081250 C7orf50 -0.61 -12.29 -0.44 2.51e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs870825 0.872 rs12507711 chr4:185571776 C/T cg04058563 chr4:185651563 MLF1IP 0.68 11.86 0.42 1.8e-29 Blood protein levels; BRCA cis rs4481887 1.000 rs10788775 chr1:248471945 C/G cg13385794 chr1:248469461 NA 0.28 8.01 0.3 5.61e-15 Common traits (Other); BRCA cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs911555 0.755 rs34411783 chr14:103900639 G/A cg24130564 chr14:104152367 KLC1 0.35 7.95 0.3 8.76e-15 Intelligence (multi-trait analysis); BRCA cis rs7598759 0.679 rs6437019 chr2:232327707 T/C cg19187155 chr2:232395269 NMUR1 0.37 7.92 0.3 1.04e-14 Noise-induced hearing loss; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg11905131 chr22:24372483 LOC391322 -0.53 -12.13 -0.43 1.25e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.61 -0.32 5.91e-17 Monocyte percentage of white cells; BRCA cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.58 9.55 0.35 2.75e-20 Lung function (FEV1/FVC); BRCA cis rs2839186 0.934 rs17176520 chr21:47682081 T/C cg12379764 chr21:47803548 PCNT -0.39 -8.46 -0.32 1.79e-16 Testicular germ cell tumor; BRCA cis rs3008870 1.000 rs3008848 chr1:67379284 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.49 0.65 1.55e-77 Lymphocyte percentage of white cells; BRCA cis rs6087990 0.735 rs2424915 chr20:31378448 C/T cg13636640 chr20:31349939 DNMT3B 0.56 16.24 0.54 6.62e-50 Ulcerative colitis; BRCA cis rs6570726 0.791 rs370654 chr6:145879005 C/G cg05347473 chr6:146136440 FBXO30 0.42 8.39 0.32 3.02e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs36096196 0.891 rs12081179 chr1:2251119 A/G cg18313694 chr15:45480185 SHF 0.46 8.83 0.33 1.01e-17 Coronary artery disease; BRCA cis rs9443645 0.901 rs9352664 chr6:79566162 G/T cg11833968 chr6:79620685 NA -0.41 -9.26 -0.34 3.12e-19 Intelligence (multi-trait analysis); BRCA cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg06808227 chr14:105710500 BRF1 -0.8 -15.89 -0.53 3.55e-48 Mean platelet volume;Platelet distribution width; BRCA cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg06453172 chr10:134556979 INPP5A -0.61 -11.94 -0.43 7.95e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg16339924 chr4:17578868 LAP3 0.62 15.38 0.52 1.21e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg13126279 chr21:47581558 C21orf56 0.5 10.89 0.4 1.89e-25 Testicular germ cell tumor; BRCA cis rs7617773 0.817 rs745116 chr3:48272536 T/G cg11946769 chr3:48343235 NME6 0.62 13.5 0.47 1e-36 Coronary artery disease; BRCA cis rs1448094 0.512 rs61930862 chr12:86246567 A/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.83e-19 Major depressive disorder; BRCA cis rs4975616 0.804 rs381949 chr5:1322468 G/A cg06550200 chr5:1325588 CLPTM1L -0.63 -13.5 -0.47 1.03e-36 Lung cancer; BRCA trans rs4332037 0.664 rs73046334 chr7:1887037 T/C cg11693508 chr17:37793320 STARD3 0.6 11.05 0.4 4.11e-26 Bipolar disorder; BRCA cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.545 rs316323 chr7:65610989 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.99 -0.37 6.44e-22 Aortic root size; BRCA cis rs6088580 0.524 rs6088565 chr20:33254986 A/C cg07148914 chr20:33460835 GGT7 -0.44 -8.87 -0.33 7.41e-18 Glomerular filtration rate (creatinine); BRCA cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg01849466 chr14:104193079 ZFYVE21 -0.52 -11.48 -0.41 6.92e-28 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA trans rs3857536 0.813 rs7743965 chr6:66941346 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs10911251 0.546 rs12034436 chr1:183114797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.3 0.54 3.15e-50 Colorectal cancer; BRCA cis rs4595586 0.545 rs12819907 chr12:39356906 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.54e-19 Morning vs. evening chronotype; BRCA cis rs9467773 1.000 rs2224380 chr6:26553943 G/A cg11502198 chr6:26597334 ABT1 0.48 9.62 0.36 1.45e-20 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg16339924 chr4:17578868 LAP3 0.57 14.0 0.48 5.14e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs763121 0.626 rs5757236 chr22:39073824 T/C cg14440974 chr22:39074834 NA -0.38 -9.13 -0.34 8.96e-19 Menopause (age at onset); BRCA trans rs1422110 0.681 rs35625401 chr5:85465408 G/A cg01787110 chr1:109008453 NBPF6 0.46 9.2 0.34 4.92e-19 Attention function in attention deficit hyperactive disorder; BRCA cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg17747265 chr1:1875780 NA 0.37 9.42 0.35 8.15e-20 Body mass index; BRCA cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.96 0.4 1.01e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.500 rs7308338 chr12:34553181 A/G cg26384229 chr12:38710491 ALG10B 0.6 13.83 0.48 3.13e-38 Morning vs. evening chronotype; BRCA cis rs12995491 0.731 rs17435439 chr2:88511391 A/G cg14558114 chr2:88469736 THNSL2 -0.41 -8.96 -0.33 3.62e-18 Response to metformin (IC50); BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg21782813 chr7:2030301 MAD1L1 0.42 12.03 0.43 3.28e-30 Bipolar disorder and schizophrenia; BRCA cis rs2120243 0.874 rs7616177 chr3:157153208 A/G cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.55 0.35 2.66e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs897080 0.552 rs1068714 chr2:44634063 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.39 0.35 1.04e-19 Height; BRCA cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg26248373 chr2:1572462 NA -0.52 -10.2 -0.37 9.55e-23 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3857536 0.566 rs208463 chr6:66913962 T/A cg07460842 chr6:66804631 NA -0.54 -9.86 -0.36 1.92e-21 Blood trace element (Cu levels); BRCA cis rs7666738 0.830 rs113999196 chr4:99041961 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.18e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6120849 0.950 rs6088732 chr20:33744134 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -8.45 -0.32 1.98e-16 Protein C levels; BRCA cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg20908204 chr19:46285434 DMPK -0.27 -7.92 -0.3 1.07e-14 Coronary artery disease; BRCA cis rs2880765 0.835 rs4842884 chr15:86035174 T/C cg10818794 chr15:86012489 AKAP13 -0.31 -8.66 -0.32 3.96e-17 Coronary artery disease; BRCA cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg03477792 chr4:77819574 ANKRD56 0.64 15.41 0.52 8.45e-46 Emphysema distribution in smoking; BRCA cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg13256891 chr4:100009986 ADH5 0.47 9.06 0.34 1.52e-18 Alcohol dependence; BRCA cis rs13118159 0.801 rs13147602 chr4:1332175 A/G cg01939980 chr4:1354348 KIAA1530 0.38 10.28 0.38 5.02e-23 Longevity; BRCA cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg00686598 chr14:53173677 PSMC6 1.25 16.37 0.54 1.43e-50 Alzheimer's disease (late onset); BRCA cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg05535760 chr7:792225 HEATR2 0.73 13.12 0.46 5.7e-35 Cerebrospinal P-tau181p levels; BRCA cis rs1371614 0.635 rs6706127 chr2:27140741 C/T cg00617064 chr2:27272375 NA 0.3 7.88 0.3 1.41e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg13397359 chr6:42928475 GNMT 0.82 22.36 0.66 3.02e-82 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs198389 0.589 rs12404124 chr1:11873869 A/C cg24844545 chr1:11908347 NPPA -0.33 -8.79 -0.33 1.36e-17 B-type natriuretic peptide levels;NT-proBNP levels in acute coronary syndrome; BRCA cis rs2249625 0.523 rs2496552 chr6:72853042 T/C cg18830697 chr6:72922368 RIMS1 -0.51 -11.32 -0.41 3.36e-27 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs7772486 0.790 rs9403755 chr6:146231470 C/A cg05347473 chr6:146136440 FBXO30 -0.41 -8.06 -0.3 3.75e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7638995 0.878 rs17005384 chr3:69181552 A/G cg26574240 chr3:69171822 LMOD3 0.44 8.26 0.31 8.45e-16 Alzheimer's disease (late onset); BRCA cis rs806795 0.605 rs6935954 chr6:26255451 A/G cg00631329 chr6:26305371 NA -0.51 -13.56 -0.47 5.18e-37 Mosquito bite size; BRCA cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg11058730 chr11:34937778 PDHX;APIP 0.71 16.82 0.55 7.74e-53 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg22307297 chr20:60903441 LAMA5 0.34 9.35 0.35 1.42e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs262150 1.000 rs262150 chr7:158777934 G/A cg26536863 chr7:158807979 LOC154822 0.35 8.04 0.3 4.49e-15 Facial morphology (factor 20); BRCA cis rs6088813 1.000 rs6142360 chr20:33960486 T/C cg14752227 chr20:34000481 UQCC -0.39 -7.96 -0.3 7.9e-15 Height; BRCA cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg02659138 chr7:134003124 SLC35B4 0.32 9.49 0.35 4.53e-20 Mean platelet volume; BRCA cis rs796364 0.806 rs188102 chr2:200903189 T/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.45 -0.38 1.09e-23 Schizophrenia; BRCA cis rs1949733 0.701 rs4696828 chr4:8455604 G/A cg13073564 chr4:8508604 NA 0.39 10.48 0.38 8.21e-24 Response to antineoplastic agents; BRCA cis rs7552404 0.924 rs3818855 chr1:76198785 C/T cg22875332 chr1:76189707 ACADM 0.79 19.31 0.61 8.43e-66 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg22920501 chr2:26401640 FAM59B 0.96 16.92 0.56 2.42e-53 Gut microbiome composition (summer); BRCA cis rs908922 0.523 rs4845786 chr1:152510144 A/G cg20991723 chr1:152506922 NA 0.37 8.23 0.31 1.06e-15 Hair morphology; BRCA cis rs711245 0.574 rs1179494 chr2:36809496 C/G cg01206211 chr2:36825736 FEZ2 -0.4 -9.87 -0.36 1.83e-21 Height; BRCA trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg13010199 chr12:38710504 ALG10B -0.47 -9.43 -0.35 7.25e-20 Morning vs. evening chronotype; BRCA cis rs7246657 0.663 rs4803276 chr19:38072330 C/A cg18154014 chr19:37997991 ZNF793 0.49 9.24 0.34 3.49e-19 Coronary artery calcification; BRCA cis rs2625529 0.824 rs35167572 chr15:72378960 A/G cg16672083 chr15:72433130 SENP8 -0.84 -17.56 -0.57 1.29e-56 Red blood cell count; BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg05863683 chr7:1912471 MAD1L1 0.34 7.86 0.3 1.63e-14 Schizophrenia; BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg11279151 chr3:101281821 RG9MTD1 -0.57 -12.68 -0.45 5.12e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.19e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.796 rs6507718 chr18:44581284 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.22 0.31 1.18e-15 Personality dimensions; BRCA cis rs9341808 0.754 rs10733162 chr6:81023389 G/A cg08355045 chr6:80787529 NA 0.36 9.25 0.34 3.37e-19 Sitting height ratio; BRCA cis rs7789940 0.904 rs7459185 chr7:75934640 C/G cg10167463 chr7:75959203 YWHAG 0.39 7.94 0.3 9.29e-15 Multiple sclerosis; BRCA cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 19.2 0.6 3.37e-65 Platelet count; BRCA cis rs1801251 0.727 rs6437071 chr2:233568793 G/A cg25237894 chr2:233734115 C2orf82 0.31 8.82 0.33 1.06e-17 Coronary artery disease; BRCA cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.57 -0.39 3.69e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs561341 1.000 rs498391 chr17:30328704 G/A cg12193833 chr17:30244370 NA -0.54 -8.61 -0.32 5.56e-17 Hip circumference adjusted for BMI; BRCA trans rs7824557 0.767 rs7837036 chr8:11175489 A/G cg06636001 chr8:8085503 FLJ10661 0.57 10.61 0.39 2.44e-24 Retinal vascular caliber; BRCA cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.06e-21 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg04518342 chr5:131593106 PDLIM4 0.4 9.08 0.34 1.35e-18 Acylcarnitine levels; BRCA cis rs60871478 0.838 rs7789321 chr7:800977 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.56 8.23 0.31 1.01e-15 Cerebrospinal P-tau181p levels; BRCA cis rs2288073 0.965 rs13387930 chr2:24414400 A/G cg06627628 chr2:24431161 ITSN2 -0.65 -12.6 -0.45 1.1e-32 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7829975 0.572 rs28730413 chr8:8795447 A/C cg06636001 chr8:8085503 FLJ10661 -0.54 -12.11 -0.43 1.62e-30 Mood instability; BRCA cis rs72615157 0.606 rs941288 chr7:99776808 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.59 9.97 0.37 7.44e-22 Lung function (FEV1/FVC); BRCA cis rs10465746 0.846 rs9700285 chr1:84336685 G/A cg10977910 chr1:84465055 TTLL7 0.5 10.0 0.37 5.83e-22 Obesity-related traits; BRCA cis rs6456156 0.586 rs1358883 chr6:167467433 C/G cg07741184 chr6:167504864 NA -0.32 -9.55 -0.35 2.64e-20 Primary biliary cholangitis; BRCA cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs698833 0.852 rs4953089 chr2:44565024 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.76 0.39 6.5e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs782590 0.902 rs782601 chr2:55848244 T/C cg18811423 chr2:55921094 PNPT1 0.71 22.36 0.66 3.18e-82 Metabolic syndrome; BRCA cis rs60843830 0.661 rs11674477 chr2:105822 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.46 8.17 0.31 1.61e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9837602 0.529 rs1087198 chr3:99524381 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.4 -0.52 1.02e-45 Breast cancer; BRCA cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg03146154 chr1:46216737 IPP 0.46 10.12 0.37 2e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6089584 0.546 rs6061980 chr20:60618877 G/A cg06108461 chr20:60628389 TAF4 -0.69 -14.26 -0.49 2.84e-40 Body mass index; BRCA cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.44 0.5 3.99e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs55883249 1.000 rs10495571 chr2:9736066 A/G cg23886495 chr2:9695866 ADAM17 0.54 8.01 0.3 5.55e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs4363385 0.818 rs406350 chr1:153007492 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs698813 0.604 rs7606004 chr2:44479983 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.42 0.32 2.39e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs8028182 0.549 rs56395816 chr15:75664571 A/T cg25207952 chr15:75499952 C15orf39 -0.32 -7.9 -0.3 1.21e-14 Sudden cardiac arrest; BRCA cis rs3749237 0.964 rs2352967 chr3:49871641 C/T cg03060546 chr3:49711283 APEH 0.47 10.04 0.37 4.06e-22 Resting heart rate; BRCA cis rs12497850 0.931 rs11924597 chr3:48937790 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.65 0.36 1.14e-20 Parkinson's disease; BRCA cis rs8014204 1.000 rs8014204 chr14:75322794 A/G cg06637938 chr14:75390232 RPS6KL1 0.58 11.55 0.42 3.86e-28 Caffeine consumption; BRCA cis rs932287 0.536 rs10840160 chr11:9053536 C/T cg12365402 chr11:9010492 NRIP3 -0.38 -7.96 -0.3 7.78e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg24812749 chr6:127587940 RNF146 0.89 20.79 0.64 9.64e-74 Breast cancer; BRCA trans rs2018683 0.707 rs2057957 chr7:28974626 A/C cg19402173 chr7:128379420 CALU 0.42 9.97 0.37 7.63e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs4319547 0.695 rs10734915 chr12:122873408 A/C cg23029597 chr12:123009494 RSRC2 -0.49 -9.92 -0.37 1.17e-21 Body mass index; BRCA cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg08000102 chr2:233561755 GIGYF2 -0.45 -9.73 -0.36 5.74e-21 Coronary artery disease; BRCA cis rs12618769 0.597 rs10199199 chr2:99061834 T/C cg10123293 chr2:99228465 UNC50 0.42 8.42 0.32 2.51e-16 Bipolar disorder; BRCA cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs2075371 0.965 rs2544216 chr7:133987902 G/A cg02659138 chr7:134003124 SLC35B4 0.33 10.34 0.38 2.74e-23 Mean platelet volume; BRCA cis rs701145 0.585 rs1727948 chr3:153876929 G/T cg17054900 chr3:154042577 DHX36 0.55 9.41 0.35 9.09e-20 Coronary artery disease; BRCA cis rs7772486 0.875 rs854146 chr6:146341033 A/G cg23711669 chr6:146136114 FBXO30 0.73 16.63 0.55 7.47e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649213 0.559 rs56997921 chr7:98009224 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.91 -0.53 2.83e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs9400271 0.632 rs9487020 chr6:109587672 A/G cg21918786 chr6:109611834 NA -0.32 -8.02 -0.3 5.08e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA trans rs11098499 0.774 rs11098505 chr4:120284627 C/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.55 0.39 4.36e-24 Motion sickness; BRCA cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12826209 chr6:26865740 GUSBL1 0.58 10.33 0.38 3.1e-23 Intelligence (multi-trait analysis); BRCA cis rs3741798 1.000 rs61922028 chr12:12487096 A/C cg08615371 chr12:12503544 MANSC1 1.07 15.38 0.52 1.25e-45 Cerebrospinal fluid biomarker levels; BRCA cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg12310025 chr6:25882481 NA -0.55 -13.41 -0.47 2.52e-36 Blood metabolite levels; BRCA cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg04944784 chr2:26401820 FAM59B -0.95 -16.86 -0.55 5.15e-53 Gut microbiome composition (summer); BRCA cis rs9646954 0.542 rs4149512 chr2:101022886 C/T cg08017756 chr2:100939284 LONRF2 -0.31 -7.97 -0.3 7.58e-15 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.527 rs12196485 chr6:79556871 A/G cg05283184 chr6:79620031 NA -0.37 -8.57 -0.32 7.53e-17 Intelligence (multi-trait analysis); BRCA cis rs2249625 0.874 rs1852705 chr6:72875512 G/T cg18830697 chr6:72922368 RIMS1 -0.38 -8.2 -0.31 1.33e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs34779708 0.931 rs2148482 chr10:35348910 A/G cg03585969 chr10:35415529 CREM 0.49 10.27 0.38 5.13e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg15506890 chr2:3487001 NA -0.57 -12.88 -0.45 6.43e-34 Neurofibrillary tangles; BRCA cis rs10870270 1.000 rs10870270 chr10:133754334 G/A cg17892150 chr10:133769511 PPP2R2D -0.73 -15.98 -0.53 1.27e-48 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg05863683 chr7:1912471 MAD1L1 0.41 8.61 0.32 5.91e-17 Bipolar disorder and schizophrenia; BRCA cis rs78487399 0.908 rs6731636 chr2:43843046 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -8.16 -0.31 1.74e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs478304 0.651 rs4014192 chr11:65498915 C/T cg10518572 chr11:65560635 OVOL1 -0.28 -8.11 -0.31 2.52e-15 Acne (severe); BRCA cis rs495337 0.736 rs527892 chr20:48477454 A/C cg17835207 chr20:48524531 SPATA2 -0.5 -11.06 -0.4 3.87e-26 Psoriasis; BRCA cis rs7267979 1.000 rs2424704 chr20:25273929 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.32 0.35 1.82e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs796364 0.806 rs56216998 chr2:200944333 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.67 -10.28 -0.38 4.63e-23 Schizophrenia; BRCA cis rs9467711 0.591 rs13195279 chr6:25919431 T/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 7.83 0.3 2.1e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg24642439 chr20:33292090 TP53INP2 0.4 7.87 0.3 1.52e-14 Height; BRCA cis rs6901250 0.851 rs607372 chr6:117155929 A/G cg12892004 chr6:117198278 RFX6 -0.49 -11.42 -0.41 1.24e-27 C-reactive protein levels; BRCA cis rs13136331 0.684 rs7677103 chr4:88721279 C/G cg22416721 chr4:88570574 DMP1 0.39 8.38 0.31 3.3e-16 Sitting height ratio; BRCA cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11890956 chr21:40555474 PSMG1 -0.61 -13.62 -0.47 2.88e-37 Menarche (age at onset); BRCA cis rs12200560 0.505 rs211177 chr6:97074088 C/T cg06623918 chr6:96969491 KIAA0776 0.53 12.64 0.45 7.46e-33 Coronary heart disease; BRCA cis rs36051895 0.632 rs7029084 chr9:5174638 T/C cg02405213 chr9:5042618 JAK2 -0.46 -8.86 -0.33 7.68e-18 Pediatric autoimmune diseases; BRCA cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg00074818 chr8:8560427 CLDN23 0.38 8.41 0.32 2.69e-16 Obesity-related traits; BRCA cis rs7666738 0.830 rs6833822 chr4:98951354 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.82 0.55 8.18e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.616 rs2236666 chr21:45109856 T/C cg04455712 chr21:45112962 RRP1B 0.45 11.21 0.41 9.07e-27 Mean corpuscular volume; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg16606324 chr3:10149918 C3orf24 0.5 10.1 0.37 2.28e-22 Alzheimer's disease; BRCA cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg18225595 chr11:63971243 STIP1 -0.4 -9.88 -0.36 1.67e-21 Platelet count; BRCA cis rs6121246 0.697 rs45557936 chr20:30226690 G/A cg13852791 chr20:30311386 BCL2L1 0.8 14.98 0.51 1.08e-43 Mean corpuscular hemoglobin; BRCA cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg25554036 chr4:6271136 WFS1 0.39 9.65 0.36 1.13e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12667521 chr19:29218732 NA 0.46 8.79 0.33 1.33e-17 Methadone dose in opioid dependence; BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.96 -0.3 8.15e-15 Total body bone mineral density; BRCA cis rs35995292 0.534 rs2392607 chr7:38930380 G/A cg19327137 chr7:38886074 VPS41 0.38 12.75 0.45 2.57e-33 Subjective well-being (multi-trait analysis); BRCA cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.12e-21 Developmental language disorder (linguistic errors); BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg23285459 chr7:2802560 GNA12 -0.34 -8.34 -0.31 4.6e-16 Height; BRCA cis rs40363 0.645 rs1690450 chr16:3521051 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.42 -7.93 -0.3 9.52e-15 Tuberculosis; BRCA cis rs17253792 0.915 rs76952651 chr14:56188994 G/A cg01858014 chr14:56050164 KTN1 -0.68 -8.45 -0.32 2.02e-16 Putamen volume; BRCA cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg11843238 chr5:131593191 PDLIM4 0.38 9.34 0.35 1.56e-19 Acylcarnitine levels; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg10729496 chr3:10149963 C3orf24 0.41 7.81 0.3 2.4e-14 Alzheimer's disease; BRCA cis rs9393692 0.905 rs9366649 chr6:26329103 A/T cg05868516 chr6:26286170 HIST1H4H -0.49 -10.71 -0.39 9.68e-25 Educational attainment; BRCA cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg24112000 chr20:60950667 NA -0.58 -12.47 -0.44 4.11e-32 Colorectal cancer; BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg21782813 chr7:2030301 MAD1L1 -0.38 -10.4 -0.38 1.72e-23 Bipolar disorder and schizophrenia; BRCA cis rs11190604 0.767 rs11190519 chr10:102175133 C/T cg07080220 chr10:102295463 HIF1AN 0.49 10.04 0.37 4.17e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2742234 0.541 rs10899779 chr10:43723976 C/T cg02780029 chr10:43622663 RET 0.35 7.9 0.3 1.26e-14 Hirschsprung disease; BRCA cis rs490234 0.702 rs7864945 chr9:128373469 C/T cg14078157 chr9:128172775 NA -0.53 -11.64 -0.42 1.49e-28 Mean arterial pressure; BRCA cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg12386194 chr3:101231763 SENP7 0.46 9.76 0.36 4.43e-21 Colorectal cancer; BRCA cis rs7666738 0.830 rs7663924 chr4:99037679 A/G cg17366294 chr4:99064904 C4orf37 -0.44 -10.37 -0.38 2.22e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.92 -17.02 -0.56 7.2e-54 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.01 17.7 0.57 2.47e-57 Gut microbiome composition (summer); BRCA trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg11608241 chr8:8085544 FLJ10661 0.28 8.13 0.31 2.29e-15 Neuroticism; BRCA cis rs34779708 0.801 rs34592588 chr10:35540134 A/G cg03585969 chr10:35415529 CREM 0.45 9.22 0.34 4.14e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.34 0.35 1.63e-19 Body mass index; BRCA cis rs13046373 0.535 rs2226377 chr21:32031915 T/C cg06468780 chr21:31798236 KRTAP13-3 0.35 8.47 0.32 1.74e-16 HDL cholesterol; BRCA cis rs1005277 0.579 rs2983343 chr10:38383332 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.92 -0.56 2.46e-53 Extrinsic epigenetic age acceleration; BRCA cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.83 12.84 0.45 9.76e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7772486 0.790 rs2249147 chr6:146184999 T/C cg05347473 chr6:146136440 FBXO30 0.39 8.06 0.3 3.89e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2836974 0.544 rs8128919 chr21:40711862 C/T cg11890956 chr21:40555474 PSMG1 0.66 15.41 0.52 8.84e-46 Cognitive function; BRCA trans rs3733585 0.699 rs7435196 chr4:9967556 A/C cg26043149 chr18:55253948 FECH -0.37 -8.18 -0.31 1.49e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs4594175 0.926 rs4318127 chr14:51624897 G/C cg23942311 chr14:51606299 NA 0.33 8.45 0.32 2e-16 Cancer; BRCA cis rs6977660 0.714 rs4719587 chr7:19828174 C/G cg07541023 chr7:19748670 TWISTNB 0.52 9.04 0.34 1.93e-18 Thyroid stimulating hormone; BRCA cis rs2404602 0.647 rs7178250 chr15:77099107 T/C cg23625390 chr15:77176239 SCAPER -0.55 -13.87 -0.48 1.98e-38 Blood metabolite levels; BRCA cis rs9633740 1.000 rs10749609 chr10:82249752 G/A cg01528321 chr10:82214614 TSPAN14 0.94 18.38 0.59 6.97e-61 Post bronchodilator FEV1; BRCA cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg22974920 chr21:40686053 BRWD1 -0.38 -8.7 -0.33 2.86e-17 Cognitive function; BRCA cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs2191566 1.000 rs390369 chr19:44506984 C/T cg20607764 chr19:44506953 ZNF230 0.49 10.92 0.4 1.39e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs9644630 0.870 rs10888165 chr8:19358961 T/C cg01280390 chr8:19363452 CSGALNACT1 0.38 8.67 0.32 3.53e-17 Oropharynx cancer; BRCA cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg11301795 chr4:187892539 NA 0.3 9.66 0.36 1.06e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg04317338 chr11:64019027 PLCB3 -0.54 -9.11 -0.34 1.05e-18 Mean platelet volume; BRCA cis rs72772090 0.710 rs17479052 chr5:96065636 A/G cg24982541 chr5:96078678 CAST -0.46 -7.95 -0.3 8.51e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2836974 0.899 rs114399588 chr21:40653958 G/A cg11644478 chr21:40555479 PSMG1 0.74 15.01 0.51 8.03e-44 Cognitive function; BRCA cis rs67340775 0.541 rs200975 chr6:27855625 G/T cg26587870 chr6:27730563 NA -0.45 -8.03 -0.3 4.73e-15 Lung cancer in ever smokers; BRCA cis rs6435161 0.919 rs72930744 chr2:203597269 C/T cg18429434 chr2:203499731 FAM117B -0.46 -9.02 -0.34 2.1e-18 Total cholesterol levels; BRCA trans rs561341 1.000 rs757009 chr17:30243937 A/G cg20587970 chr11:113659929 NA -0.82 -15.39 -0.52 1.13e-45 Hip circumference adjusted for BMI; BRCA cis rs1372520 0.873 rs2736989 chr4:90776257 T/C cg15133208 chr4:90757351 SNCA -0.38 -8.03 -0.3 4.61e-15 Neuroticism; BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg22800045 chr5:56110881 MAP3K1 -0.68 -12.98 -0.46 2.27e-34 Initial pursuit acceleration; BRCA cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg12292205 chr6:26970375 C6orf41 -0.8 -19.61 -0.61 2.16e-67 Autism spectrum disorder or schizophrenia; BRCA cis rs35110281 0.627 rs7282704 chr21:44966253 A/G cg04455712 chr21:45112962 RRP1B 0.39 9.92 0.37 1.1e-21 Mean corpuscular volume; BRCA cis rs10751667 0.666 rs7395402 chr11:950293 A/G cg01483505 chr11:975446 AP2A2 -0.32 -8.88 -0.33 6.53e-18 Alzheimer's disease (late onset); BRCA cis rs17164103 0.505 rs10500136 chr7:143014244 C/T cg21852589 chr7:142981689 TMEM139 -0.69 -14.14 -0.49 1.11e-39 Cancer; BRCA cis rs6754311 0.517 rs1469996 chr2:136542560 A/G cg07169764 chr2:136633963 MCM6 0.98 19.48 0.61 1.11e-66 Mosquito bite size; BRCA cis rs12545109 0.836 rs2196586 chr8:57347126 C/T cg09654669 chr8:57350985 NA 0.38 7.96 0.3 7.92e-15 Obesity-related traits; BRCA cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg21770322 chr7:97807741 LMTK2 -0.49 -12.12 -0.43 1.4e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.509 rs10932782 chr2:219353195 C/T cg02176678 chr2:219576539 TTLL4 0.45 11.62 0.42 1.97e-28 Mean corpuscular hemoglobin concentration; BRCA trans rs7980799 0.935 rs1905427 chr12:33534368 T/C cg26384229 chr12:38710491 ALG10B -0.4 -8.33 -0.31 5.1e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs191220855 1 rs191220855 chr2:200778130 A/G cg23649088 chr2:200775458 C2orf69 -0.67 -9.6 -0.36 1.76e-20 Chickenpox; BRCA cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg19784903 chr17:45786737 TBKBP1 -0.35 -8.24 -0.31 9.99e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs17401966 0.627 rs35859381 chr1:10466040 G/A cg03954927 chr1:10346856 KIF1B 0.44 13.28 0.47 1.03e-35 Hepatocellular carcinoma; BRCA cis rs67478160 0.643 rs7147171 chr14:104264857 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.37 -0.41 2.06e-27 Schizophrenia; BRCA cis rs7640424 0.819 rs34154497 chr3:107824222 T/C cg09227934 chr3:107805635 CD47 -0.4 -8.41 -0.32 2.69e-16 Body mass index; BRCA cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg16230307 chr14:35515116 FAM177A1 0.62 13.96 0.48 7.67e-39 Psoriasis; BRCA cis rs9287719 0.967 rs12995602 chr2:10753542 C/A cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs2762353 0.845 rs1937130 chr6:25787554 T/A cg12310025 chr6:25882481 NA 0.51 11.99 0.43 4.85e-30 Blood metabolite levels; BRCA cis rs4808199 0.948 rs757000 chr19:19448301 A/G cg03709012 chr19:19516395 GATAD2A 1.0 18.63 0.59 3.29e-62 Nonalcoholic fatty liver disease; BRCA cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.52 -0.32 1.18e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs877282 0.583 rs7072970 chr10:822757 G/A cg22713356 chr15:30763199 NA 1.01 15.85 0.53 6.01e-48 Uric acid levels; BRCA cis rs9341808 0.718 rs35447745 chr6:80816748 T/C cg08355045 chr6:80787529 NA 0.37 9.37 0.35 1.27e-19 Sitting height ratio; BRCA cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.8e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs796364 0.806 rs11688194 chr2:200916239 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg00083206 chr6:110721305 DDO 0.36 8.58 0.32 7.37e-17 Platelet distribution width; BRCA cis rs919433 0.963 rs10199410 chr2:198155776 A/T cg03934865 chr2:198174659 NA -0.38 -8.22 -0.31 1.14e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs4679121 0.642 rs76826102 chr3:126185964 C/T cg01106040 chr3:126194903 ZXDC -0.7 -8.04 -0.3 4.5e-15 Pursuit maintenance gain; BRCA cis rs3008870 0.583 rs2147838 chr1:67399466 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.89 16.77 0.55 1.47e-52 Lymphocyte percentage of white cells; BRCA cis rs7666738 0.791 rs7657399 chr4:98851861 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.56 0.5 1.14e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.935 rs382910 chr6:145865941 G/A cg23711669 chr6:146136114 FBXO30 0.63 14.68 0.5 2.93e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg13319975 chr6:146136371 FBXO30 -0.42 -9.81 -0.36 2.95e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.791 rs34790496 chr4:98930516 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.31 0.38 3.57e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.593 rs6465665 chr7:97934150 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.81 0.42 2.92e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs9733 0.596 rs72702556 chr1:150680115 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.91 0.3 1.11e-14 Tonsillectomy; BRCA cis rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05901451 chr6:126070800 HEY2 -0.55 -14.83 -0.51 5.6e-43 Brugada syndrome; BRCA cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg24060327 chr5:131705240 SLC22A5 -0.63 -12.25 -0.44 3.84e-31 Breast cancer; BRCA trans rs4714291 0.802 rs1474870 chr6:39980359 C/T cg02267698 chr19:7991119 CTXN1 0.43 8.9 0.33 5.75e-18 Strep throat; BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -11.64 -0.42 1.62e-28 Alzheimer's disease; BRCA cis rs7116495 0.609 rs10501408 chr11:71680590 C/T cg26138937 chr11:71823887 C11orf51 -1.01 -9.91 -0.36 1.27e-21 Severe influenza A (H1N1) infection; BRCA cis rs7582180 0.544 rs13026570 chr2:100939498 A/C cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.15e-14 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg18132916 chr6:79620363 NA -0.44 -9.97 -0.37 7.3e-22 Intelligence (multi-trait analysis); BRCA cis rs9290065 0.519 rs10936216 chr3:160698314 G/C cg03342759 chr3:160939853 NMD3 -0.49 -10.06 -0.37 3.49e-22 Kawasaki disease; BRCA cis rs6089584 0.888 rs6587283 chr20:60613727 A/C cg13770153 chr20:60521292 NA -0.43 -9.38 -0.35 1.15e-19 Body mass index; BRCA cis rs6834538 0.965 rs4834294 chr4:113529020 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.39 8.47 0.32 1.7e-16 Free thyroxine concentration; BRCA cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs6060717 0.536 rs7271036 chr20:34467215 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.59 8.08 0.3 3.21e-15 Hip circumference adjusted for BMI; BRCA cis rs6138458 1.000 rs6106984 chr20:24977006 T/C cg26195577 chr20:24973756 C20orf3 1.03 28.97 0.75 1.65e-118 Blood protein levels; BRCA cis rs778371 0.871 rs2675954 chr2:233750627 C/G cg08000102 chr2:233561755 GIGYF2 -0.77 -17.07 -0.56 4.13e-54 Schizophrenia; BRCA cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.44 -9.98 -0.37 6.79e-22 Personality dimensions; BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg12648201 chr2:27665141 KRTCAP3 -0.37 -9.09 -0.34 1.24e-18 Total body bone mineral density; BRCA cis rs10911363 0.509 rs10911339 chr1:183442097 C/T cg09173681 chr1:183549694 NCF2 0.59 12.18 0.43 7.93e-31 Systemic lupus erythematosus; BRCA cis rs735860 0.737 rs2397139 chr6:53150804 C/G cg10236188 chr6:53219634 NA -0.38 -8.21 -0.31 1.23e-15 Glaucoma; BRCA cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg10932868 chr11:921992 NA -0.48 -12.28 -0.44 2.84e-31 Alzheimer's disease (late onset); BRCA cis rs11608355 0.515 rs4766476 chr12:109934700 A/G cg05360138 chr12:110035743 NA 0.74 13.68 0.48 1.56e-37 Neuroticism; BRCA trans rs3733585 0.673 rs10000983 chr4:9951606 T/C cg26043149 chr18:55253948 FECH -0.36 -7.87 -0.3 1.51e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10465746 0.714 rs12141272 chr1:84434517 C/T cg10977910 chr1:84465055 TTLL7 0.57 11.98 0.43 5.5e-30 Obesity-related traits; BRCA cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg27286337 chr10:134555280 INPP5A -0.64 -10.94 -0.4 1.16e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6424115 1.000 rs12031592 chr1:24127864 A/C cg15997130 chr1:24165203 NA 0.49 12.96 0.46 2.96e-34 Immature fraction of reticulocytes; BRCA cis rs7833986 0.534 rs72653924 chr8:56906088 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.57 0.45 1.6e-32 Height; BRCA cis rs7246657 0.722 rs12979640 chr19:38179156 T/C cg14683738 chr19:37701593 ZNF585B -0.5 -8.74 -0.33 2.08e-17 Coronary artery calcification; BRCA cis rs6674176 0.597 rs2352990 chr1:44393276 T/A cg12908607 chr1:44402522 ARTN -0.41 -9.98 -0.37 6.52e-22 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs10771431 0.935 rs1117735 chr12:9372728 G/A cg27600084 chr12:12264075 NA 0.39 9.17 0.34 6.34e-19 Breast size; BRCA cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs61931739 0.500 rs11053140 chr12:34316122 T/C cg13010199 chr12:38710504 ALG10B 0.48 9.45 0.35 6.55e-20 Morning vs. evening chronotype; BRCA cis rs752010 0.619 rs10736421 chr1:42106230 G/A cg06885757 chr1:42089581 HIVEP3 0.33 11.0 0.4 6.94e-26 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2652834 1.000 rs2729783 chr15:63403316 C/T cg05507819 chr15:63340323 TPM1 0.47 8.59 0.32 6.55e-17 HDL cholesterol; BRCA cis rs11690935 0.851 rs10201430 chr2:172813241 T/C cg13550731 chr2:172543902 DYNC1I2 -0.75 -22.26 -0.66 1.02e-81 Schizophrenia; BRCA cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.78 0.5 9.3e-43 Colorectal cancer; BRCA cis rs6121246 0.559 rs6058352 chr20:30269179 T/C cg13852791 chr20:30311386 BCL2L1 0.96 23.31 0.68 1.8e-87 Mean corpuscular hemoglobin; BRCA cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg13877915 chr19:58951672 ZNF132 0.4 9.38 0.35 1.13e-19 Uric acid clearance; BRCA cis rs8031584 0.958 rs61997079 chr15:31238271 G/C cg08704250 chr15:31115839 NA -0.36 -9.13 -0.34 9e-19 Huntington's disease progression; BRCA cis rs9341808 0.628 rs9294172 chr6:80918561 G/A cg08355045 chr6:80787529 NA 0.32 7.92 0.3 1.05e-14 Sitting height ratio; BRCA cis rs34779708 0.733 rs7914560 chr10:35548099 G/A cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9733 0.596 rs6678013 chr1:150623285 T/G cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg24562669 chr7:97807699 LMTK2 0.43 11.48 0.41 7.55e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs6745190 0.575 rs6706696 chr2:181981055 C/T cg00481216 chr2:181971175 NA 0.4 9.53 0.35 3.22e-20 White blood cell count; BRCA cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg18876405 chr7:65276391 NA 0.62 15.35 0.52 1.74e-45 Aortic root size; BRCA cis rs17376456 0.825 rs10058331 chr5:93279115 T/G cg21475434 chr5:93447410 FAM172A 0.7 8.74 0.33 2.03e-17 Diabetic retinopathy; BRCA cis rs7809950 0.954 rs2520247 chr7:107143946 A/T cg23024343 chr7:107201750 COG5 -0.39 -9.13 -0.34 8.89e-19 Coronary artery disease; BRCA cis rs9325144 0.505 rs1906262 chr12:38653605 A/G cg26384229 chr12:38710491 ALG10B 0.6 15.33 0.52 2.21e-45 Morning vs. evening chronotype; BRCA cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg10523679 chr1:76189770 ACADM -0.76 -16.11 -0.54 2.86e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9818758 0.607 rs11719220 chr3:49245201 A/G cg00383909 chr3:49044727 WDR6 0.76 12.7 0.45 4.07e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg21747090 chr2:27597821 SNX17 -0.45 -9.7 -0.36 7.9e-21 Total body bone mineral density; BRCA cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg27211696 chr2:191398769 TMEM194B -0.45 -10.34 -0.38 2.89e-23 Pulse pressure; BRCA cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.72 0.55 2.61e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg09060608 chr5:178986726 RUFY1 0.55 12.7 0.45 3.94e-33 Lung cancer; BRCA cis rs6120849 0.901 rs6088739 chr20:33748724 G/A cg24642439 chr20:33292090 TP53INP2 0.48 8.61 0.32 5.6e-17 Protein C levels; BRCA cis rs1577917 0.958 rs6454487 chr6:86446868 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 11.73 0.42 6.31e-29 Response to antipsychotic treatment; BRCA cis rs2404602 0.647 rs11855296 chr15:77092962 C/T cg23625390 chr15:77176239 SCAPER -0.56 -12.86 -0.45 8.39e-34 Blood metabolite levels; BRCA cis rs7959452 0.868 rs10878967 chr12:69740869 T/C cg14784868 chr12:69753453 YEATS4 0.51 12.47 0.44 4.34e-32 Blood protein levels; BRCA cis rs3796619 0.924 rs4690209 chr4:1077575 G/A cg27284194 chr4:1044797 NA 0.43 9.3 0.35 2.12e-19 Recombination rate (males); BRCA trans rs56176327 0.532 rs9849038 chr3:49771990 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.37 -0.31 3.65e-16 Intelligence (multi-trait analysis); BRCA cis rs507080 0.922 rs561845 chr11:118558827 A/G cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs16867321 0.950 rs4667223 chr2:181498302 C/G cg23363182 chr2:181467187 NA -0.44 -8.26 -0.31 8.35e-16 Obesity; BRCA cis rs9858542 0.953 rs35169793 chr3:49423274 A/G cg03060546 chr3:49711283 APEH -0.51 -10.51 -0.38 6.34e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg02297831 chr4:17616191 MED28 0.36 8.61 0.32 5.52e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg12386194 chr3:101231763 SENP7 0.45 9.45 0.35 6.18e-20 Colorectal cancer; BRCA trans rs208515 0.556 rs1872309 chr6:66660432 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.75 13.64 0.47 2.38e-37 Exhaled nitric oxide levels; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg18402987 chr7:1209562 NA 0.85 12.22 0.44 5.38e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8180040 0.739 rs12488225 chr3:47235107 G/A cg16586182 chr3:47516702 SCAP -0.56 -12.85 -0.45 8.73e-34 Colorectal cancer; BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg03934478 chr11:495069 RNH1 0.79 11.76 0.42 5.06e-29 Body mass index; BRCA cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg05347473 chr6:146136440 FBXO30 -0.6 -11.46 -0.41 8.44e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs7903847 0.642 rs1537645 chr10:99149914 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.77 -0.33 1.63e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs812925 0.537 rs778153 chr2:61608652 A/G cg15711740 chr2:61764176 XPO1 0.32 7.85 0.3 1.74e-14 Immature fraction of reticulocytes; BRCA cis rs4363385 0.720 rs1134220 chr1:152976306 T/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.75 -0.36 4.91e-21 Inflammatory skin disease; BRCA cis rs812925 0.533 rs35507645 chr2:61396766 A/G cg15711740 chr2:61764176 XPO1 -0.32 -7.85 -0.3 1.72e-14 Immature fraction of reticulocytes; BRCA cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg05535760 chr7:792225 HEATR2 0.77 13.59 0.47 3.77e-37 Cerebrospinal P-tau181p levels; BRCA cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg24829409 chr8:58192753 C8orf71 0.45 8.71 0.33 2.68e-17 Developmental language disorder (linguistic errors); BRCA cis rs9942416 0.660 rs66493518 chr5:74990125 G/C cg19683494 chr5:74908142 NA 0.48 9.04 0.34 1.78e-18 Age-related disease endophenotypes; BRCA cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg05623727 chr3:50126028 RBM5 0.44 10.43 0.38 1.22e-23 Intelligence (multi-trait analysis); BRCA cis rs10464366 1.000 rs10951593 chr7:39121390 C/T cg18850127 chr7:39170497 POU6F2 0.41 8.4 0.32 2.96e-16 IgG glycosylation; BRCA cis rs10504229 1.000 rs68076606 chr8:58191271 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.32 0.38 3.25e-23 Motion sickness; BRCA cis rs847577 0.715 rs4729402 chr7:97707731 A/G cg21770322 chr7:97807741 LMTK2 0.44 11.96 0.43 6.53e-30 Breast cancer; BRCA cis rs9658691 0.607 rs9658766 chr10:90771612 G/A cg03111039 chr10:90751583 FAS;ACTA2 -0.55 -8.04 -0.3 4.34e-15 Mosquito bite size; BRCA cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg21770322 chr7:97807741 LMTK2 0.42 11.25 0.41 6.77e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs7072216 0.763 rs2274243 chr10:100175267 T/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 8.8e-21 Metabolite levels; BRCA cis rs6977660 1.000 rs57916046 chr7:19800542 T/C cg07541023 chr7:19748670 TWISTNB 0.48 8.63 0.32 4.78e-17 Thyroid stimulating hormone; BRCA trans rs7615952 0.599 rs12496921 chr3:125701948 C/G cg07211511 chr3:129823064 LOC729375 -0.61 -10.74 -0.39 7.24e-25 Blood pressure (smoking interaction); BRCA cis rs9399135 0.967 rs7763836 chr6:135362378 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.3 0.44 2.41e-31 Red blood cell count; BRCA cis rs216205 0.547 rs2641431 chr17:2030507 C/G cg16513277 chr17:2031491 SMG6 -0.5 -8.89 -0.33 6.11e-18 Mitral valve prolapse; BRCA trans rs12439619 0.810 rs28876157 chr15:82509049 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.39 -7.93 -0.3 9.59e-15 Intelligence (multi-trait analysis); BRCA cis rs7131987 0.675 rs1436322 chr12:29554805 A/G cg09582351 chr12:29534625 ERGIC2 0.34 8.11 0.31 2.58e-15 QT interval; BRCA cis rs13392177 0.637 rs61041183 chr2:219056380 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.39 8.4 0.32 2.99e-16 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg00149659 chr3:10157352 C3orf10 0.74 12.96 0.46 2.94e-34 Alzheimer's disease; BRCA cis rs1476670 0.710 rs2477616 chr1:44504809 G/A cg09470012 chr1:44509516 NA 0.44 9.33 0.35 1.71e-19 Eotaxin levels; BRCA cis rs7772486 0.686 rs857879 chr6:145974043 C/A cg23711669 chr6:146136114 FBXO30 -0.71 -17.19 -0.56 1.03e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs7412746 0.658 rs10305714 chr1:150800655 C/T cg17724175 chr1:150552817 MCL1 -0.24 -7.86 -0.3 1.6e-14 Melanoma; BRCA cis rs7918232 0.607 rs1755401 chr10:27405763 A/C cg14240646 chr10:27532245 ACBD5 -0.72 -9.31 -0.35 2.1e-19 Breast cancer; BRCA cis rs34779708 0.966 rs4934537 chr10:35441512 C/T cg03585969 chr10:35415529 CREM 0.56 11.58 0.42 2.9e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg13628971 chr7:2884303 GNA12 0.4 9.04 0.34 1.8e-18 Height; BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg02951883 chr7:2050386 MAD1L1 0.51 13.22 0.46 1.87e-35 Bipolar disorder and schizophrenia; BRCA cis rs12971120 0.947 rs8084109 chr18:72168312 T/A cg26446133 chr18:72167187 CNDP2 -0.79 -19.95 -0.62 3.38e-69 Refractive error; BRCA cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.44 9.9 0.36 1.35e-21 Calcium levels; BRCA cis rs2346177 0.605 rs7598712 chr2:46660452 G/T cg02822958 chr2:46747628 ATP6V1E2 0.52 11.12 0.4 2.17e-26 HDL cholesterol; BRCA cis rs35110281 0.633 rs4819289 chr21:45120237 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -10.47 -0.38 9.03e-24 Mean corpuscular volume; BRCA cis rs17270561 0.636 rs3922681 chr6:25698481 C/T cg17691542 chr6:26056736 HIST1H1C 0.47 8.96 0.33 3.56e-18 Iron status biomarkers; BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg18230493 chr5:56204884 C5orf35 -0.71 -13.93 -0.48 1.01e-38 Initial pursuit acceleration; BRCA cis rs858239 0.537 rs6942981 chr7:23231548 C/T cg23682824 chr7:23144976 KLHL7 0.35 8.85 0.33 8.39e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs758324 0.891 rs491624 chr5:131270222 A/T cg06307176 chr5:131281290 NA -0.53 -10.18 -0.37 1.17e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs11231017 0.501 rs11231053 chr11:62133220 G/A cg23876832 chr11:62092739 NA 0.32 8.21 0.31 1.23e-15 HIV-1 viral setpoint; BRCA cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.13e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg12564285 chr5:131593104 PDLIM4 0.43 11.25 0.41 6.39e-27 Acylcarnitine levels; BRCA cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.24 0.56 5.67e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs10464366 0.746 rs4723822 chr7:39141613 C/T cg18850127 chr7:39170497 POU6F2 0.48 10.35 0.38 2.51e-23 IgG glycosylation; BRCA cis rs147120681 1 rs147120681 chr1:101239293 CT/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.42 -9.61 -0.36 1.67e-20 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg03264133 chr6:25882463 NA -0.56 -11.5 -0.41 5.82e-28 Intelligence (multi-trait analysis); BRCA cis rs10129255 0.536 rs10142951 chr14:107190574 A/G cg07958169 chr14:107095056 NA -0.4 -8.54 -0.32 9.55e-17 Kawasaki disease; BRCA cis rs4481887 1.000 rs7511706 chr1:248467360 G/A cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA trans rs2562456 0.917 rs6511256 chr19:21693315 G/T cg25042112 chr7:64838748 ZNF92 0.46 8.58 0.32 7.29e-17 Pain; BRCA cis rs9486719 1.000 rs2205755 chr6:96864704 A/G cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA cis rs2882667 0.898 rs3828600 chr5:138386859 G/T cg04439458 chr5:138467593 SIL1 -0.35 -9.67 -0.36 1.02e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg09877947 chr5:131593287 PDLIM4 -0.45 -10.61 -0.39 2.41e-24 Acylcarnitine levels; BRCA cis rs694739 0.628 rs617051 chr11:64133638 C/A cg23796481 chr11:64053134 BAD;GPR137 0.5 10.52 0.38 5.41e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs10479542 0.701 rs10479541 chr5:178981003 G/C cg00080972 chr5:178986291 RUFY1 0.38 8.98 0.33 2.99e-18 Lung cancer; BRCA cis rs7727544 0.735 rs2569266 chr5:131706791 T/C cg24060327 chr5:131705240 SLC22A5 0.5 10.38 0.38 1.9e-23 Blood metabolite levels; BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg05863683 chr7:1912471 MAD1L1 -0.41 -9.25 -0.34 3.33e-19 Bipolar disorder and schizophrenia; BRCA cis rs514406 0.825 rs487453 chr1:53271225 T/C cg24675658 chr1:53192096 ZYG11B 0.55 12.37 0.44 1.11e-31 Monocyte count; BRCA cis rs2836633 0.894 rs55955614 chr21:40037330 T/G cg05519781 chr21:40033154 ERG 0.44 9.34 0.35 1.61e-19 Coronary artery disease; BRCA cis rs870825 0.550 rs35981185 chr4:185639720 A/C cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA cis rs1555322 0.530 rs2425042 chr20:33865895 G/A cg03689076 chr20:33865952 NA 0.48 8.56 0.32 8.38e-17 Attention deficit hyperactivity disorder; BRCA trans rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.55 -13.86 -0.48 2.11e-38 Brugada syndrome; BRCA cis rs7524258 0.868 rs6693725 chr1:7307810 G/T cg07173049 chr1:7289937 CAMTA1 0.42 10.28 0.38 4.87e-23 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs908922 0.676 rs1538082 chr1:152517304 A/G cg20991723 chr1:152506922 NA 0.38 8.67 0.32 3.48e-17 Hair morphology; BRCA cis rs9814567 1.000 rs6439487 chr3:134260860 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.94 0.33 4.23e-18 Motion sickness; BRCA cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs701145 0.585 rs357465 chr3:153903095 T/A cg17054900 chr3:154042577 DHX36 0.58 9.66 0.36 1.04e-20 Coronary artery disease; BRCA cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.98 -0.3 6.85e-15 Bipolar disorder; BRCA trans rs7824557 0.767 rs6991606 chr8:11176159 G/A cg06636001 chr8:8085503 FLJ10661 0.56 10.47 0.38 8.57e-24 Retinal vascular caliber; BRCA cis rs9814567 0.806 rs11927539 chr3:134319448 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11585357 0.895 rs2501795 chr1:17633499 A/G cg19159961 chr1:17633534 PADI4 0.6 10.58 0.39 3.16e-24 Hair shape; BRCA cis rs7944584 0.879 rs11039182 chr11:47346723 T/C cg03711944 chr11:47377212 SPI1 -0.39 -8.42 -0.32 2.52e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs965469 0.779 rs6133039 chr20:3385006 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.78 -0.33 1.55e-17 IFN-related cytopenia; BRCA cis rs1707322 1.000 rs11211222 chr1:46367757 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg08888203 chr3:10149979 C3orf24 0.59 8.98 0.33 2.96e-18 Alzheimer's disease; BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26314531 chr2:26401878 FAM59B -0.9 -15.64 -0.53 6.69e-47 Gut microbiome composition (summer); BRCA cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg22307297 chr20:60903441 LAMA5 0.34 9.2 0.34 4.93e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs11190604 1.000 rs2495758 chr10:102321900 C/G cg07080220 chr10:102295463 HIF1AN 0.62 13.27 0.46 1.08e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs55882075 0.722 rs10903245 chr5:179133608 T/C cg14593053 chr5:179126677 CANX 0.48 12.69 0.45 4.38e-33 Monocyte percentage of white cells; BRCA cis rs56104184 0.775 rs56317021 chr19:49395960 C/T cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.54 -0.35 2.84e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs9287719 0.967 rs7605461 chr2:10738134 G/A cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs9463078 0.547 rs9472362 chr6:44751285 C/A cg25276700 chr6:44698697 NA 0.34 7.91 0.3 1.16e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs3768617 0.510 rs2333621 chr1:183090751 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.08e-57 Fuchs's corneal dystrophy; BRCA cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg11189052 chr15:85197271 WDR73 -0.39 -9.39 -0.35 1.04e-19 P wave terminal force; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg21280719 chr6:42927975 GNMT -0.31 -13.05 -0.46 1.17e-34 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs1945213 0.694 rs12222077 chr11:55848116 T/A cg03929089 chr4:120376271 NA 0.6 10.37 0.38 2.13e-23 Acute lymphoblastic leukemia (childhood); BRCA trans rs6598955 0.627 rs7550127 chr1:26592871 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.62 -13.07 -0.46 9e-35 Obesity-related traits; BRCA cis rs9787249 1.000 rs9787249 chr1:40212878 G/A cg02773041 chr1:40204384 PPIE 0.44 9.55 0.35 2.79e-20 Blood protein levels; BRCA cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg06618935 chr21:46677482 NA -0.38 -8.46 -0.32 1.87e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4889855 0.505 rs8082303 chr17:78605012 A/G cg16591659 chr17:78472290 NA -0.31 -7.88 -0.3 1.38e-14 Fractional excretion of uric acid; BRCA cis rs801193 0.569 rs11761542 chr7:66218196 G/A cg11764359 chr7:65958608 NA 0.75 16.63 0.55 7.35e-52 Aortic root size; BRCA cis rs12541635 1.000 rs11992752 chr8:107083122 G/A cg10147462 chr8:107024639 NA -0.31 -8.42 -0.32 2.47e-16 Age of smoking initiation; BRCA cis rs881375 0.678 rs4836834 chr9:123665901 T/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 12.06 0.43 2.62e-30 Rheumatoid arthritis; BRCA cis rs72772090 0.539 rs72775810 chr5:96185307 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.57 -11.44 -0.41 1.02e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21659725 chr3:3221576 CRBN 0.71 21.67 0.65 1.79e-78 Intelligence (multi-trait analysis); BRCA cis rs4908768 0.501 rs35865480 chr1:8603777 C/T cg20416874 chr1:8611966 RERE -0.29 -8.25 -0.31 8.99e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs3820928 1.000 rs4673173 chr2:227769493 A/C cg11843606 chr2:227700838 RHBDD1 -0.41 -8.95 -0.33 3.93e-18 Pulmonary function; BRCA cis rs6089584 1.000 rs3787424 chr20:60559219 G/A cg12751644 chr20:60527061 NA -0.33 -7.83 -0.3 2.09e-14 Body mass index; BRCA cis rs10754283 0.967 rs7546410 chr1:90109815 C/T cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6088813 0.961 rs2425063 chr20:33924273 C/A cg14752227 chr20:34000481 UQCC 0.41 8.59 0.32 6.4e-17 Height; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg22903471 chr2:27725779 GCKR -0.38 -9.22 -0.34 4.36e-19 Total body bone mineral density; BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.08 0.3 3.33e-15 Platelet count; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg18402987 chr7:1209562 NA 0.42 8.11 0.31 2.65e-15 Longevity;Endometriosis; BRCA cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg12549451 chr6:135224345 NA -0.36 -8.63 -0.32 4.69e-17 Red blood cell count; BRCA cis rs17539620 0.624 rs4566892 chr6:154837346 C/T cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg02503808 chr4:7069936 GRPEL1 0.8 18.43 0.59 3.81e-61 Monocyte percentage of white cells; BRCA cis rs6582630 0.623 rs12299293 chr12:38436288 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.99 -0.37 6.04e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs4845875 0.626 rs2004445 chr1:11841366 C/T cg24844545 chr1:11908347 NPPA 0.33 8.25 0.31 9.01e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7267979 0.966 rs6050567 chr20:25354561 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1994135 0.617 rs2200155 chr12:33734935 G/A cg06521331 chr12:34319734 NA -0.44 -8.18 -0.31 1.54e-15 Resting heart rate; BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.15 0.4 1.72e-26 Platelet count; BRCA cis rs7833986 0.501 rs72653917 chr8:56892844 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.67 12.45 0.44 5.19e-32 Height; BRCA cis rs2882667 0.858 rs11951899 chr5:138374310 A/G cg04439458 chr5:138467593 SIL1 -0.43 -10.36 -0.38 2.28e-23 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -9.48 -0.35 4.96e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs10465746 0.780 rs7551787 chr1:84419297 A/G cg10977910 chr1:84465055 TTLL7 0.53 11.16 0.4 1.5e-26 Obesity-related traits; BRCA cis rs4819052 0.851 rs1056099 chr21:46678892 G/A cg06618935 chr21:46677482 NA -0.36 -8.06 -0.3 3.7e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs155076 0.938 rs261375 chr13:21871882 A/G cg06138931 chr13:21896616 NA 0.54 8.96 0.33 3.54e-18 White matter hyperintensity burden; BRCA cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.24 -8.47 -0.32 1.65e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs7193541 0.684 rs4888262 chr16:74670458 C/T cg01733217 chr16:74700730 RFWD3 0.92 32.44 0.79 3.54e-137 Multiple myeloma; BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg04944784 chr2:26401820 FAM59B -0.69 -11.45 -0.41 9.33e-28 Gut microbiome composition (summer); BRCA trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg26384229 chr12:38710491 ALG10B 0.57 12.85 0.45 9.02e-34 Morning vs. evening chronotype; BRCA cis rs367943 1.000 rs348960 chr5:112820651 C/A cg12552261 chr5:112820674 MCC 0.55 12.04 0.43 3.23e-30 Type 2 diabetes; BRCA cis rs9287719 0.967 rs7570118 chr2:10718007 G/T cg02196655 chr2:10830764 NOL10 -0.29 -7.84 -0.3 1.94e-14 Prostate cancer; BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg08470875 chr2:26401718 FAM59B -0.5 -8.09 -0.3 3.09e-15 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs2904967 0.852 rs668735 chr11:65045725 G/T cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs35110281 0.748 rs2838322 chr21:44998615 G/C cg21573476 chr21:45109991 RRP1B -0.36 -9.22 -0.34 4.22e-19 Mean corpuscular volume; BRCA cis rs11874712 0.933 rs8097521 chr18:43666952 C/A cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg27170947 chr2:26402098 FAM59B 0.97 16.91 0.56 2.72e-53 Gut microbiome composition (summer); BRCA cis rs10493773 0.862 rs12075929 chr1:86248138 A/C cg17807903 chr1:86174739 ZNHIT6 0.46 10.27 0.38 5.07e-23 Urate levels in overweight individuals; BRCA cis rs6580649 1.000 rs6580647 chr12:48403229 G/T cg24011408 chr12:48396354 COL2A1 -0.52 -9.13 -0.34 8.75e-19 Lung cancer; BRCA cis rs8180040 0.783 rs11710121 chr3:47351501 T/G cg16586182 chr3:47516702 SCAP 0.61 13.43 0.47 2.11e-36 Colorectal cancer; BRCA cis rs9287719 0.781 rs6714795 chr2:10759134 C/T cg00105475 chr2:10696890 NA 0.42 9.6 0.36 1.74e-20 Prostate cancer; BRCA cis rs72615157 0.628 rs7801070 chr7:99847147 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.74 14.45 0.5 3.72e-41 Lung function (FEV1/FVC); BRCA cis rs13394619 0.565 rs12478958 chr2:11748037 A/G cg07314298 chr2:11723111 GREB1 -0.4 -9.34 -0.35 1.54e-19 Endometriosis; BRCA cis rs9287719 0.649 rs10803724 chr2:10732323 C/T cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg23711669 chr6:146136114 FBXO30 0.78 19.15 0.6 6.21e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg22307297 chr20:60903441 LAMA5 0.33 9.44 0.35 6.88e-20 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs812925 0.519 rs1186706 chr2:61673394 G/T cg15711740 chr2:61764176 XPO1 -0.34 -8.34 -0.31 4.49e-16 Immature fraction of reticulocytes; BRCA cis rs61931739 0.534 rs11053005 chr12:34091626 A/C cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.35e-26 Morning vs. evening chronotype; BRCA cis rs1163251 0.837 rs2764886 chr1:120241771 C/T cg19096424 chr1:120255104 PHGDH 0.45 10.3 0.38 4.15e-23 Blood metabolite levels; BRCA cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg03433033 chr1:76189801 ACADM 0.89 23.79 0.69 4.28e-90 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg19748678 chr4:122722346 EXOSC9 0.65 14.01 0.48 4.39e-39 Type 2 diabetes; BRCA cis rs11718455 0.960 rs11921942 chr3:44007957 T/C cg08738300 chr3:44038990 NA 0.45 8.88 0.33 6.83e-18 Coronary artery disease; BRCA cis rs6076065 0.548 rs1112819 chr20:23323987 A/G cg11657817 chr20:23433608 CST11 0.33 8.09 0.3 3.04e-15 Facial morphology (factor 15, philtrum width); BRCA cis rs61990749 0.597 rs1549119 chr14:78219812 A/T cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.57 0.39 3.61e-24 Fibroblast growth factor basic levels; BRCA trans rs6598955 0.671 rs12068212 chr1:26612935 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.69 -16.67 -0.55 4.25e-52 Obesity-related traits; BRCA cis rs870825 0.929 rs72689269 chr4:185592085 T/C cg04058563 chr4:185651563 MLF1IP 0.68 11.7 0.42 8.45e-29 Blood protein levels; BRCA cis rs4268898 0.552 rs12620938 chr2:24367122 C/A cg06627628 chr2:24431161 ITSN2 0.4 8.51 0.32 1.24e-16 Asthma; BRCA cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.64 9.99 0.37 6.08e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11088226 1.000 rs2833888 chr21:33927560 A/G cg09050820 chr6:167586206 TCP10L2 0.49 8.22 0.31 1.1e-15 Gastritis; BRCA cis rs11758351 1.000 rs80259160 chr6:26190199 C/T cg01420254 chr6:26195488 NA 0.58 9.03 0.34 2.08e-18 Gout;Renal underexcretion gout; BRCA cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg23649088 chr2:200775458 C2orf69 -0.58 -8.89 -0.33 6.28e-18 Schizophrenia; BRCA cis rs4805272 0.539 rs11883172 chr19:29318536 C/T cg04546413 chr19:29218101 NA 0.45 8.25 0.31 9.32e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.43e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs11758351 0.866 rs56186759 chr6:26207181 C/T cg01420254 chr6:26195488 NA 0.53 8.54 0.32 9.95e-17 Gout;Renal underexcretion gout; BRCA cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg08213375 chr14:104286397 PPP1R13B 0.63 17.27 0.56 3.87e-55 Schizophrenia; BRCA cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg18904891 chr8:8559673 CLDN23 -0.67 -14.11 -0.49 1.55e-39 Obesity-related traits; BRCA cis rs698813 0.674 rs6544753 chr2:44501895 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.12 0.31 2.44e-15 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg19346786 chr7:2764209 NA 0.3 8.87 0.33 7.46e-18 Height; BRCA cis rs7666738 0.791 rs7684521 chr4:99071219 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.54 0.38 4.56e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg03264133 chr6:25882463 NA 0.72 16.67 0.55 4.42e-52 Blood metabolite levels; BRCA cis rs478304 0.651 rs10896037 chr11:65503424 A/G cg10518572 chr11:65560635 OVOL1 -0.28 -8.1 -0.31 2.86e-15 Acne (severe); BRCA cis rs9818758 0.607 rs73084135 chr3:49272218 A/G cg01304814 chr3:48885189 PRKAR2A 0.71 7.88 0.3 1.4e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs4363385 0.747 rs3964619 chr1:152972811 A/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.02 -0.34 2.12e-18 Inflammatory skin disease; BRCA cis rs8017423 0.647 rs4904673 chr14:90817338 G/A cg04374321 chr14:90722782 PSMC1 -0.5 -11.99 -0.43 5.23e-30 Mortality in heart failure; BRCA cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg18964960 chr10:1102726 WDR37 0.65 8.85 0.33 8.82e-18 Eosinophil percentage of granulocytes; BRCA cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs9467773 1.000 rs9467782 chr6:26542773 G/A cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs12995491 0.933 rs34029976 chr2:88537797 T/C cg04511125 chr2:88470314 THNSL2 -0.45 -9.13 -0.34 8.61e-19 Response to metformin (IC50); BRCA cis rs514406 0.607 rs1930305 chr1:53195481 G/T cg16325326 chr1:53192061 ZYG11B -0.94 -26.17 -0.72 3.62e-103 Monocyte count; BRCA cis rs7662987 0.517 rs2602872 chr4:100038996 A/G cg12011299 chr4:100065546 ADH4 0.48 11.21 0.41 9.8e-27 Smoking initiation; BRCA cis rs3820068 0.603 rs6695903 chr1:15985940 C/T cg17385448 chr1:15911702 AGMAT 0.41 9.33 0.35 1.73e-19 Systolic blood pressure; BRCA cis rs701145 0.585 rs1713813 chr3:153873643 T/G cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs1865721 0.804 rs59187673 chr18:73143964 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.46 -0.38 9.32e-24 Intelligence; BRCA cis rs1878931 0.624 rs37810 chr16:3451881 C/T cg02880119 chr16:3481970 NA 0.43 7.97 0.3 7.36e-15 Body mass index (adult); BRCA cis rs11792861 0.890 rs3750465 chr9:111900677 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.11 0.31 2.61e-15 Menarche (age at onset); BRCA cis rs992157 0.767 rs2014615 chr2:219171191 A/G cg20019365 chr2:219134978 PNKD;AAMP 0.51 11.09 0.4 3e-26 Colorectal cancer; BRCA cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg08000102 chr2:233561755 GIGYF2 0.64 14.27 0.49 2.56e-40 Coronary artery disease; BRCA cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg22875332 chr1:76189707 ACADM 0.61 11.74 0.42 5.97e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg04166393 chr7:2884313 GNA12 0.6 11.93 0.43 9.21e-30 Height; BRCA cis rs858239 0.738 rs7807879 chr7:23260588 G/T cg23682824 chr7:23144976 KLHL7 0.36 9.26 0.34 3.01e-19 Cerebrospinal fluid biomarker levels; BRCA cis rs2249625 0.545 rs2496487 chr6:72875226 G/C cg18830697 chr6:72922368 RIMS1 -0.64 -14.66 -0.5 3.57e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs9341808 0.591 rs6454147 chr6:80916328 G/A cg08355045 chr6:80787529 NA 0.32 7.95 0.3 8.27e-15 Sitting height ratio; BRCA cis rs2425143 1.000 rs73905926 chr20:34251982 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.8 -0.33 1.31e-17 Blood protein levels; BRCA trans rs931812 1.000 rs4734494 chr8:101917721 T/C cg20993868 chr7:22813445 NA 0.47 13.13 0.46 4.68e-35 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs6782228 0.606 rs2712381 chr3:128338600 A/C cg16766828 chr3:128327626 NA -0.42 -9.54 -0.35 2.9e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg00814883 chr7:100076585 TSC22D4 -0.51 -11.49 -0.41 6.47e-28 Platelet count; BRCA cis rs6910061 0.830 rs6906360 chr6:11118427 C/T cg27233058 chr6:11094804 LOC221710 0.48 8.36 0.31 4.02e-16 Diabetic kidney disease; BRCA trans rs2832077 0.943 rs11702320 chr21:30195251 A/T cg14791747 chr16:20752902 THUMPD1 0.4 9.42 0.35 8.16e-20 Cognitive test performance; BRCA cis rs6089584 0.606 rs6089599 chr20:60576992 A/G cg06108461 chr20:60628389 TAF4 0.62 12.9 0.45 5.2e-34 Body mass index; BRCA cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg18129178 chr5:148520854 ABLIM3 -0.59 -12.3 -0.44 2.44e-31 Breast cancer; BRCA cis rs7666738 0.830 rs11097600 chr4:98959564 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 2.03e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7903847 0.642 rs6584127 chr10:99142948 A/C cg08345082 chr10:99160200 RRP12 -0.29 -8.37 -0.31 3.54e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs11229555 0.645 rs4579945 chr11:58190873 T/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7737355 0.947 rs6882552 chr5:130841493 A/G cg06307176 chr5:131281290 NA 0.54 10.64 0.39 1.89e-24 Life satisfaction; BRCA cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg01579765 chr21:45077557 HSF2BP 0.41 10.14 0.37 1.69e-22 Mean corpuscular volume; BRCA cis rs2404602 0.967 rs12148805 chr15:76800659 G/A cg23625390 chr15:77176239 SCAPER 0.43 10.75 0.39 6.84e-25 Blood metabolite levels; BRCA cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg21573476 chr21:45109991 RRP1B -0.38 -10.44 -0.38 1.18e-23 Mean corpuscular volume; BRCA cis rs17270561 0.609 rs1179086 chr6:25791745 A/T cg16482183 chr6:26056742 HIST1H1C 0.41 8.78 0.33 1.49e-17 Iron status biomarkers; BRCA cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14442939 chr10:27389572 ANKRD26 0.53 9.29 0.34 2.37e-19 Breast cancer; BRCA cis rs4927850 1.000 rs7627706 chr3:195753353 A/C cg00031303 chr3:195681400 NA 0.45 8.54 0.32 9.64e-17 Pancreatic cancer; BRCA cis rs9314323 0.798 rs12682345 chr8:26218332 A/G cg13160058 chr8:26243215 BNIP3L 0.43 11.08 0.4 3.36e-26 Red cell distribution width; BRCA cis rs2204008 0.869 rs34438288 chr12:38211582 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg09877947 chr5:131593287 PDLIM4 0.44 10.06 0.37 3.32e-22 Acylcarnitine levels; BRCA cis rs7959452 0.557 rs899224 chr12:69784774 A/G cg20891283 chr12:69753455 YEATS4 0.73 21.66 0.65 1.94e-78 Blood protein levels; BRCA cis rs765787 0.530 rs11070444 chr15:45513121 T/C cg24006582 chr15:45444508 DUOX1 0.56 11.26 0.41 6.01e-27 Uric acid levels; BRCA cis rs9309473 1.000 rs7598419 chr2:73798223 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -11.51 -0.41 5.54e-28 Metabolite levels; BRCA trans rs9393777 0.841 rs13191474 chr6:27413345 C/T cg01620082 chr3:125678407 NA -0.75 -9.59 -0.35 1.86e-20 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1371614 0.635 rs9309559 chr2:27141515 G/T cg12368169 chr2:27073192 DPYSL5 0.28 8.42 0.32 2.57e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6430585 0.528 rs114760827 chr2:136661110 G/A cg07169764 chr2:136633963 MCM6 1.23 23.98 0.69 3.98e-91 Corneal structure; BRCA trans rs208520 0.955 rs208538 chr6:66964492 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.78 -13.59 -0.47 3.96e-37 Exhaled nitric oxide output; BRCA cis rs2637266 1.000 rs7896379 chr10:78366247 C/T cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg13010199 chr12:38710504 ALG10B -0.54 -12.01 -0.43 4.15e-30 Heart rate; BRCA cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.806 rs115717210 chr2:201006247 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA cis rs2075165 0.901 rs10908492 chr1:156224795 C/T cg20302342 chr1:156215951 PAQR6 0.33 7.85 0.3 1.73e-14 Tonsillectomy; BRCA cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg12927641 chr6:109611667 NA -0.37 -9.11 -0.34 1.05e-18 Reticulocyte fraction of red cells; BRCA cis rs4363385 0.747 rs4478766 chr1:152984906 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.35 -0.31 4.16e-16 Inflammatory skin disease; BRCA cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.48 -9.77 -0.36 4.14e-21 Tonsillectomy; BRCA cis rs1595825 0.838 rs16823400 chr2:198603229 A/G cg19156104 chr2:198669113 PLCL1 -0.41 -7.83 -0.3 2.02e-14 Ulcerative colitis; BRCA cis rs4595586 0.545 rs6580910 chr12:39390052 C/A cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg17136484 chr7:158649327 WDR60 0.41 8.73 0.33 2.13e-17 Height; BRCA cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg12310025 chr6:25882481 NA 0.42 9.47 0.35 5.4e-20 Intelligence (multi-trait analysis); BRCA cis rs701145 0.556 rs355764 chr3:154013480 A/T cg16511985 chr3:153974050 SGEF 0.49 11.14 0.4 1.91e-26 Coronary artery disease; BRCA cis rs8062405 1.000 rs12325113 chr16:28848668 T/C cg09754948 chr16:28834200 ATXN2L 0.46 8.45 0.32 2.02e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs7618501 0.633 rs9853222 chr3:50022926 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.31 0.35 2.03e-19 Intelligence (multi-trait analysis); BRCA cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg16405210 chr4:1374714 KIAA1530 -0.45 -10.44 -0.38 1.17e-23 Longevity; BRCA cis rs7174348 1 rs7174348 chr15:78792439 G/A cg24631222 chr15:78858424 CHRNA5 0.49 9.5 0.35 4.08e-20 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs36051895 0.589 rs16922786 chr9:5200714 A/G cg02405213 chr9:5042618 JAK2 -0.44 -8.46 -0.32 1.85e-16 Pediatric autoimmune diseases; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg16145915 chr7:1198662 ZFAND2A -0.48 -9.77 -0.36 4.23e-21 Bronchopulmonary dysplasia; BRCA cis rs11608355 0.545 rs56144717 chr12:109902304 T/C cg05360138 chr12:110035743 NA 0.71 13.03 0.46 1.38e-34 Neuroticism; BRCA cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.11 0.37 2.23e-22 Aortic root size; BRCA cis rs17401966 0.838 rs4475756 chr1:10387788 A/G cg03954927 chr1:10346856 KIF1B 0.43 14.06 0.49 2.49e-39 Hepatocellular carcinoma; BRCA cis rs13046373 0.508 rs13048637 chr21:31999055 T/G cg06468780 chr21:31798236 KRTAP13-3 0.33 8.07 0.3 3.5e-15 HDL cholesterol; BRCA cis rs1997103 1.000 rs4628219 chr7:55410449 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7312933 0.510 rs61942483 chr12:42499538 T/A cg01256987 chr12:42539512 GXYLT1 -0.7 -16.89 -0.56 3.35e-53 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2836950 0.565 rs4816617 chr21:40540690 T/C cg11890956 chr21:40555474 PSMG1 -0.6 -13.36 -0.47 4.21e-36 Menarche (age at onset); BRCA cis rs6088580 0.634 rs6087587 chr20:33058628 G/T cg24642439 chr20:33292090 TP53INP2 0.54 11.6 0.42 2.25e-28 Glomerular filtration rate (creatinine); BRCA cis rs12701220 0.504 rs12702092 chr7:1145868 G/A cg02733842 chr7:1102375 C7orf50 -0.6 -10.6 -0.39 2.67e-24 Bronchopulmonary dysplasia; BRCA cis rs13256369 1.000 rs885000 chr8:8568875 G/T cg17143192 chr8:8559678 CLDN23 0.55 10.5 0.38 6.52e-24 Obesity-related traits; BRCA trans rs6076960 0.684 rs6038408 chr20:6268983 A/C cg17788362 chr6:86352627 SYNCRIP 0.44 8.6 0.32 6.09e-17 Smooth-surface caries; BRCA cis rs7631605 0.935 rs9819025 chr3:37073287 T/G cg15934958 chr3:37212084 LRRFIP2 0.41 9.54 0.35 3e-20 Cerebrospinal P-tau181p levels; BRCA trans rs11098499 0.780 rs7680914 chr4:120563053 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.22 0.31 1.12e-15 Corneal astigmatism; BRCA cis rs936229 0.813 rs7085 chr15:75095483 T/C cg10253484 chr15:75165896 SCAMP2 -0.51 -9.75 -0.36 5.09e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg18964960 chr10:1102726 WDR37 0.6 8.02 0.3 5.2e-15 Eosinophil percentage of granulocytes; BRCA cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg22862634 chr11:62369728 EML3;MTA2 0.55 13.19 0.46 2.56e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs912057 0.671 rs1294420 chr6:6742752 C/T cg06612196 chr6:6737390 NA 0.46 10.82 0.39 3.65e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg10057126 chr4:77819792 ANKRD56 0.65 15.21 0.52 8.53e-45 Emphysema distribution in smoking; BRCA cis rs67478160 0.643 rs12434686 chr14:104316033 C/T cg26031613 chr14:104095156 KLC1 0.44 8.74 0.33 1.98e-17 Schizophrenia; BRCA cis rs12477438 0.700 rs12467679 chr2:99654449 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.91 -0.58 1.96e-58 Chronic sinus infection; BRCA cis rs1555322 0.530 rs2425043 chr20:33868702 T/C cg03689076 chr20:33865952 NA 0.44 8.1 0.31 2.74e-15 Attention deficit hyperactivity disorder; BRCA cis rs11098499 0.779 rs10857066 chr4:120286596 C/T cg09307838 chr4:120376055 NA 0.66 14.3 0.49 1.9e-40 Corneal astigmatism; BRCA cis rs8072100 0.902 rs12051716 chr17:45582395 G/A cg25173405 chr17:45401733 C17orf57 0.45 9.27 0.34 2.71e-19 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7560272 0.501 rs6750494 chr2:73946496 G/A cg20560298 chr2:73613845 ALMS1 0.33 8.53 0.32 1.06e-16 Schizophrenia; BRCA cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg19508488 chr2:152266495 RIF1 0.49 10.6 0.39 2.68e-24 Lung cancer; BRCA cis rs875971 0.861 rs801215 chr7:66011938 A/T cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA trans rs1493916 0.837 rs2123333 chr18:31410730 G/A cg15819921 chr19:927150 ARID3A -0.41 -8.11 -0.31 2.57e-15 Life satisfaction; BRCA cis rs2243480 1.000 rs2257790 chr7:65600450 C/T cg18252515 chr7:66147081 NA -1.04 -15.22 -0.52 7.66e-45 Diabetic kidney disease; BRCA cis rs7552404 1.000 rs7516226 chr1:76234257 G/A cg03433033 chr1:76189801 ACADM 0.75 16.21 0.54 9.49e-50 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9818758 0.607 rs73084135 chr3:49272218 A/G cg00383909 chr3:49044727 WDR6 0.93 14.32 0.49 1.6e-40 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9788721 0.836 rs17484235 chr15:78761414 C/G cg18825076 chr15:78729989 IREB2 -0.45 -8.73 -0.33 2.13e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg13047869 chr3:10149882 C3orf24 0.55 10.19 0.37 1.03e-22 Alzheimer's disease; BRCA cis rs9487051 0.872 rs9374079 chr6:109609619 A/G cg12927641 chr6:109611667 NA -0.42 -10.81 -0.39 4.04e-25 Reticulocyte fraction of red cells; BRCA cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg11822812 chr5:140052017 DND1 0.33 9.13 0.34 9.26e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs11828289 0.660 rs17306426 chr11:23222079 G/T cg20040320 chr11:23191996 NA 0.55 7.91 0.3 1.1e-14 Cancer; BRCA cis rs11608355 0.545 rs11615949 chr12:109894347 G/A cg05360138 chr12:110035743 NA 0.71 13.1 0.46 6.6e-35 Neuroticism; BRCA cis rs4363385 0.818 rs9659389 chr1:152989844 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.32 -0.31 5.13e-16 Inflammatory skin disease; BRCA cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg23583168 chr7:148888333 NA -0.84 -19.08 -0.6 1.46e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.73 16.48 0.55 4.05e-51 Lymphocyte counts; BRCA cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.06 -0.34 1.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.88 13.89 0.48 1.53e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.38 -0.31 3.41e-16 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.5 -0.32 1.36e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08109568 chr15:31115862 NA -0.45 -10.64 -0.39 1.84e-24 Huntington's disease progression; BRCA cis rs4930561 0.714 rs7122250 chr11:67946472 T/C cg04465784 chr11:67976953 SUV420H1 -0.26 -8.59 -0.32 6.39e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs929596 0.597 rs10173355 chr2:234597321 A/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.4 -9.67 -0.36 9.65e-21 Total bilirubin levels in HIV-1 infection; BRCA cis rs9486719 0.894 rs34826652 chr6:96899085 A/G cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.97e-34 Migraine;Coronary artery disease; BRCA trans rs9467711 0.790 rs13195401 chr6:26463574 G/T cg01620082 chr3:125678407 NA -0.83 -9.45 -0.35 6.18e-20 Autism spectrum disorder or schizophrenia; BRCA trans rs656319 0.629 rs10111315 chr8:9865588 G/A cg15556689 chr8:8085844 FLJ10661 -0.33 -8.61 -0.32 5.79e-17 Myopia (pathological); BRCA cis rs7474896 0.583 rs12776092 chr10:38015795 G/C cg25427524 chr10:38739819 LOC399744 -0.54 -9.45 -0.35 6.5e-20 Obesity (extreme); BRCA cis rs6598955 0.671 rs11247909 chr1:26640135 G/A cg00852783 chr1:26633632 UBXN11 -0.45 -7.93 -0.3 1.02e-14 Obesity-related traits; BRCA cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg27129171 chr3:47204927 SETD2 -0.72 -17.31 -0.56 2.57e-55 Colorectal cancer; BRCA cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg13010199 chr12:38710504 ALG10B -0.49 -9.89 -0.36 1.5e-21 Bladder cancer; BRCA cis rs4302748 0.862 rs57133121 chr7:36182859 G/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs875971 0.545 rs3936065 chr7:65790564 C/T cg11764359 chr7:65958608 NA 0.65 11.2 0.41 1.03e-26 Aortic root size; BRCA cis rs4974559 0.895 rs12646130 chr4:1330530 G/C cg02980000 chr4:1222292 CTBP1 0.77 12.67 0.45 5.56e-33 Systolic blood pressure; BRCA cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg10802521 chr3:52805072 NEK4 0.3 7.85 0.3 1.79e-14 Bipolar disorder; BRCA cis rs7523273 0.606 rs2488252 chr1:207938228 C/T cg22525895 chr1:207977042 MIR29B2 0.47 12.04 0.43 3.08e-30 Schizophrenia; BRCA cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.97 0.37 7.69e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs870825 0.929 rs1405939 chr4:185591444 C/T cg04058563 chr4:185651563 MLF1IP 0.65 11.19 0.4 1.1e-26 Blood protein levels; BRCA trans rs3733585 0.673 rs4519796 chr4:9955936 A/G cg26043149 chr18:55253948 FECH -0.38 -8.32 -0.31 5.17e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg08132940 chr7:1081526 C7orf50 -0.44 -7.84 -0.3 1.95e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6121246 0.697 rs45557936 chr20:30226690 G/A cg21427119 chr20:30132790 HM13 -0.43 -9.03 -0.34 2e-18 Mean corpuscular hemoglobin; BRCA cis rs9287719 0.934 rs6727884 chr2:10757557 C/T cg00105475 chr2:10696890 NA -0.45 -10.46 -0.38 9.29e-24 Prostate cancer; BRCA cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg21918786 chr6:109611834 NA -0.49 -14.06 -0.49 2.61e-39 Reticulocyte fraction of red cells; BRCA cis rs2836950 0.772 rs62222988 chr21:40569508 T/C cg11890956 chr21:40555474 PSMG1 -0.54 -10.95 -0.4 1.05e-25 Menarche (age at onset); BRCA cis rs4363385 0.747 rs9919227 chr1:152970867 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -8.98 -0.33 3.11e-18 Inflammatory skin disease; BRCA cis rs7809950 1.000 rs6976607 chr7:107223401 A/C cg23024343 chr7:107201750 COG5 0.42 9.02 0.34 2.24e-18 Coronary artery disease; BRCA cis rs701145 0.730 rs2666192 chr3:154004009 T/C cg17054900 chr3:154042577 DHX36 0.68 11.79 0.42 3.71e-29 Coronary artery disease; BRCA cis rs9300255 0.543 rs520088 chr12:123522150 C/G cg00376283 chr12:123451042 ABCB9 0.48 10.9 0.4 1.68e-25 Neutrophil percentage of white cells; BRCA trans rs66887589 0.807 rs9799664 chr4:120326678 C/T cg25214090 chr10:38739885 LOC399744 0.35 8.04 0.3 4.34e-15 Diastolic blood pressure; BRCA cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg03188948 chr7:1209495 NA 0.85 8.62 0.32 5.18e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17376456 0.569 rs1026279 chr5:93209581 C/A cg25358565 chr5:93447407 FAM172A -0.67 -11.77 -0.42 4.23e-29 Diabetic retinopathy; BRCA cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.78 -0.33 1.51e-17 Developmental language disorder (linguistic errors); BRCA cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.2 -0.58 5.86e-60 Extrinsic epigenetic age acceleration; BRCA cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg20891558 chr2:74357851 NA 0.36 7.84 0.3 1.87e-14 Gestational age at birth (maternal effect); BRCA cis rs6088580 0.524 rs4911437 chr20:33266149 G/T cg08999081 chr20:33150536 PIGU -0.33 -7.83 -0.3 2.11e-14 Glomerular filtration rate (creatinine); BRCA cis rs10751667 0.643 rs7396767 chr11:938808 G/A cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.04e-15 Alzheimer's disease (late onset); BRCA trans rs6479891 0.915 rs2616628 chr10:65219957 G/C cg14819942 chr15:35414228 NA 0.35 8.59 0.32 6.62e-17 Arthritis (juvenile idiopathic); BRCA cis rs832540 0.931 rs2662040 chr5:56246610 A/G cg24531977 chr5:56204891 C5orf35 0.41 8.15 0.31 1.88e-15 Coronary artery disease; BRCA cis rs2832077 0.689 rs2832055 chr21:30132382 C/G cg08807101 chr21:30365312 RNF160 0.45 9.43 0.35 7.53e-20 Cognitive test performance; BRCA cis rs2652834 0.851 rs7170462 chr15:63345622 A/G cg05507819 chr15:63340323 TPM1 0.52 9.16 0.34 7.04e-19 HDL cholesterol; BRCA cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg22875332 chr1:76189707 ACADM 0.66 15.65 0.53 5.95e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg03146154 chr1:46216737 IPP -0.51 -11.2 -0.41 1.06e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13191362 1.000 rs55822577 chr6:163069710 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.63 9.69 0.36 8.49e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17741873 0.836 rs10824039 chr10:75602849 G/A cg07699608 chr10:75541558 CHCHD1 0.56 8.76 0.33 1.79e-17 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg23708337 chr7:1209742 NA 0.63 8.85 0.33 8.71e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7103648 0.569 rs11039266 chr11:47532395 T/G cg20307385 chr11:47447363 PSMC3 0.76 16.91 0.56 2.84e-53 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs16866061 1.000 rs2047134 chr2:225347713 A/C cg12698349 chr2:225449008 CUL3 0.76 20.26 0.63 7.31e-71 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2559856 0.904 rs2695283 chr12:102089391 G/C cg12924262 chr12:102091054 CHPT1 0.38 8.65 0.32 4.28e-17 Blood protein levels; BRCA cis rs534126 0.744 rs10248147 chr7:142941023 C/G cg22531018 chr7:142981779 TMEM139 -0.47 -10.75 -0.39 7.07e-25 Cancer; BRCA cis rs910316 1.000 rs910316 chr14:75626042 A/C cg23033748 chr14:75592666 NEK9 0.43 10.17 0.37 1.26e-22 Height; BRCA trans rs7615952 0.673 rs35001498 chr3:125628644 A/G cg07211511 chr3:129823064 LOC729375 -0.96 -13.57 -0.47 5.09e-37 Blood pressure (smoking interaction); BRCA cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg00071950 chr4:10020882 SLC2A9 0.63 16.17 0.54 1.49e-49 Bone mineral density; BRCA cis rs2346177 0.811 rs4953373 chr2:46652145 G/C cg02822958 chr2:46747628 ATP6V1E2 0.38 7.95 0.3 8.24e-15 HDL cholesterol; BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 19.97 0.62 2.63e-69 Platelet count; BRCA cis rs1832871 0.711 rs9459954 chr6:158709345 G/T cg07215822 chr6:158701037 NA -0.51 -8.21 -0.31 1.22e-15 Height; BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg00149659 chr3:10157352 C3orf10 1.07 18.11 0.58 1.87e-59 Alzheimer's disease; BRCA cis rs72772090 0.539 rs3335 chr5:96115070 T/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.16 -0.43 9.57e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10504229 0.683 rs17194529 chr8:58105647 A/G cg21724239 chr8:58056113 NA 0.57 9.25 0.34 3.22e-19 Developmental language disorder (linguistic errors); BRCA cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg06784218 chr1:46089804 CCDC17 0.45 10.7 0.39 1.08e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9287719 0.967 rs715247 chr2:10736291 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.71 0.33 2.58e-17 Personality dimensions; BRCA cis rs7301826 0.557 rs7953184 chr12:131284852 T/G cg11011512 chr12:131303247 STX2 -0.48 -12.52 -0.44 2.48e-32 Plasma plasminogen activator levels; BRCA cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg01483505 chr11:975446 AP2A2 0.33 8.98 0.33 2.93e-18 Alzheimer's disease (late onset); BRCA cis rs2629540 0.889 rs4962402 chr10:126459114 T/G cg08799069 chr10:126477246 METTL10 -0.53 -11.66 -0.42 1.29e-28 Cocaine dependence; BRCA cis rs1035144 0.506 rs7150858 chr14:81280425 T/C cg06600135 chr14:81408086 NA -0.39 -9.24 -0.34 3.66e-19 Male sexual orientation; BRCA cis rs6910061 0.830 rs36021520 chr6:11106122 C/T cg27233058 chr6:11094804 LOC221710 0.5 8.44 0.32 2.19e-16 Diabetic kidney disease; BRCA trans rs61931739 0.817 rs2636084 chr12:34130210 G/A cg26384229 chr12:38710491 ALG10B 0.44 10.55 0.39 4.3e-24 Morning vs. evening chronotype; BRCA cis rs13118159 0.801 rs7690727 chr4:1340811 C/A cg16405210 chr4:1374714 KIAA1530 -0.45 -10.41 -0.38 1.48e-23 Longevity; BRCA cis rs9467773 0.620 rs9461275 chr6:26590801 C/T cg09904177 chr6:26538194 HMGN4 0.47 15.0 0.51 8.32e-44 Intelligence (multi-trait analysis); BRCA cis rs2180341 1.000 rs6937287 chr6:127645719 T/A cg24812749 chr6:127587940 RNF146 0.88 20.75 0.63 1.58e-73 Breast cancer; BRCA cis rs2070488 0.662 rs7652475 chr3:38481341 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.55 12.86 0.45 7.71e-34 Electrocardiographic conduction measures; BRCA cis rs3125734 0.633 rs4561099 chr10:64041163 T/C cg19640130 chr10:64028056 RTKN2 -0.32 -9.15 -0.34 7.85e-19 Rheumatoid arthritis; BRCA trans rs853679 0.607 rs67340775 chr6:28304384 A/C cg06606381 chr12:133084897 FBRSL1 -0.89 -9.35 -0.35 1.42e-19 Depression; BRCA cis rs12477438 0.798 rs13414153 chr2:99624748 G/T cg08885076 chr2:99613938 TSGA10 -0.53 -12.25 -0.44 3.9e-31 Chronic sinus infection; BRCA cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg06115741 chr20:33292138 TP53INP2 -0.39 -8.64 -0.32 4.59e-17 Glomerular filtration rate (creatinine); BRCA cis rs769267 0.930 rs4808203 chr19:19568659 A/G cg01262667 chr19:19385393 TM6SF2 0.36 9.01 0.34 2.36e-18 Tonsillectomy; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg13628971 chr7:2884303 GNA12 0.47 9.42 0.35 7.9e-20 Height; BRCA cis rs654950 0.806 rs1815257 chr1:42041479 A/C cg06885757 chr1:42089581 HIVEP3 -0.3 -10.33 -0.38 3.09e-23 Airway imaging phenotypes; BRCA cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg16339924 chr4:17578868 LAP3 0.67 17.11 0.56 2.65e-54 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4819052 0.679 rs2236450 chr21:46702553 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.48 10.53 0.38 5.12e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10992471 0.603 rs747628 chr9:95289532 A/T cg14631576 chr9:95140430 CENPP -0.34 -8.34 -0.31 4.67e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg06808227 chr14:105710500 BRF1 -0.79 -16.08 -0.54 3.99e-49 Mean platelet volume;Platelet distribution width; BRCA trans rs6952808 0.608 rs6461049 chr7:2017445 C/T cg04565464 chr8:145669602 NFKBIL2 -0.37 -9.16 -0.34 7.06e-19 Bipolar disorder and schizophrenia; BRCA cis rs6942756 0.876 rs822039 chr7:129065774 A/G cg02491457 chr7:128862824 NA -0.57 -11.84 -0.42 2.31e-29 White matter hyperintensity burden; BRCA cis rs7605378 1.000 rs7577763 chr2:200681753 C/T cg23649088 chr2:200775458 C2orf69 0.49 10.1 0.37 2.33e-22 Osteoporosis; BRCA cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.21 0.49 5.09e-40 Motion sickness; BRCA cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26314531 chr2:26401878 FAM59B -0.47 -8.54 -0.32 9.5e-17 Gut microbiome composition (summer); BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg25703541 chr22:24373054 LOC391322 -0.66 -15.21 -0.52 8.21e-45 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1129187 0.967 rs6941212 chr6:42915920 A/G cg16590910 chr6:42928470 GNMT 0.43 9.61 0.36 1.65e-20 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6580649 0.943 rs1990029 chr12:48407987 C/T cg05342945 chr12:48394962 COL2A1 -0.5 -9.65 -0.36 1.18e-20 Lung cancer; BRCA cis rs13102973 0.640 rs11737779 chr4:135831516 C/T cg14419869 chr4:135874104 NA 0.47 9.64 0.36 1.24e-20 Subjective well-being; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.67 14.42 0.5 5.39e-41 Lymphocyte counts; BRCA cis rs1008375 0.932 rs10029173 chr4:17659598 C/T cg16339924 chr4:17578868 LAP3 -0.61 -14.95 -0.51 1.57e-43 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg18876405 chr7:65276391 NA -0.55 -12.97 -0.46 2.6e-34 Aortic root size; BRCA trans rs7824557 0.767 rs11250127 chr8:11170209 G/A cg15556689 chr8:8085844 FLJ10661 0.37 8.71 0.33 2.68e-17 Retinal vascular caliber; BRCA cis rs6582630 0.679 rs7301806 chr12:38596667 G/A cg26384229 chr12:38710491 ALG10B 0.44 10.6 0.39 2.77e-24 Drug-induced liver injury (flucloxacillin); BRCA trans rs3780486 0.801 rs3780495 chr9:33125942 A/C cg04842962 chr6:43655489 MRPS18A 1.13 39.06 0.84 1.82e-171 IgG glycosylation; BRCA cis rs701145 0.585 rs1727882 chr3:153837246 C/T cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs9291683 0.588 rs3756238 chr4:10013202 C/T cg00071950 chr4:10020882 SLC2A9 0.67 16.82 0.55 7.99e-53 Bone mineral density; BRCA trans rs853679 0.546 rs2232426 chr6:28360659 G/C cg06606381 chr12:133084897 FBRSL1 -0.9 -8.84 -0.33 9.38e-18 Depression; BRCA cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg26597838 chr10:835615 NA 0.98 17.29 0.56 2.96e-55 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.932 rs6517527 chr21:40581751 G/A cg11890956 chr21:40555474 PSMG1 1.06 30.01 0.76 3.96e-124 Cognitive function; BRCA cis rs2742234 0.541 rs60845448 chr10:43721462 C/T cg02780029 chr10:43622663 RET 0.35 7.86 0.3 1.69e-14 Hirschsprung disease; BRCA cis rs17253792 0.822 rs77197405 chr14:56159662 T/A cg01858014 chr14:56050164 KTN1 -0.76 -9.61 -0.36 1.57e-20 Putamen volume; BRCA cis rs11252926 0.537 rs4881274 chr10:459940 G/A cg16386425 chr10:429943 DIP2C -0.41 -8.83 -0.33 1e-17 Psychosis in Alzheimer's disease; BRCA cis rs13223928 0.621 rs4722438 chr7:3155813 A/G cg19214707 chr7:3157722 NA 0.44 11.03 0.4 5.12e-26 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs9308433 0.569 rs1353718 chr1:214459652 A/T cg06198575 chr1:214491504 SMYD2 0.51 10.67 0.39 1.44e-24 IgG glycosylation; BRCA cis rs2153535 0.563 rs1737586 chr6:8535897 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.07 0.49 2.42e-39 Motion sickness; BRCA cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs427394 0.659 rs274693 chr5:6734162 G/A cg10857441 chr5:6722123 POLS -0.31 -9.87 -0.36 1.72e-21 Menopause (age at onset); BRCA trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs992157 0.965 rs13419763 chr2:219134950 C/T cg00012203 chr2:219082015 ARPC2 0.64 13.27 0.46 1.12e-35 Colorectal cancer; BRCA cis rs4689388 0.926 rs11732178 chr4:6292643 G/C cg25554036 chr4:6271136 WFS1 0.38 9.32 0.35 1.84e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs992157 0.775 rs7559428 chr2:219150238 A/G cg00012203 chr2:219082015 ARPC2 -0.48 -9.21 -0.34 4.58e-19 Colorectal cancer; BRCA cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.64 0.39 1.94e-24 Bipolar disorder; BRCA cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg12386194 chr3:101231763 SENP7 0.44 9.52 0.35 3.43e-20 Colorectal cancer; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg17158414 chr2:27665306 KRTCAP3 -0.35 -9.15 -0.34 7.76e-19 Total body bone mineral density; BRCA cis rs7647973 1.000 rs62259933 chr3:49469703 G/A cg07636037 chr3:49044803 WDR6 -0.75 -16.03 -0.54 7.41e-49 Menarche (age at onset); BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg18279126 chr7:2041391 MAD1L1 0.37 8.0 0.3 5.76e-15 Bipolar disorder and schizophrenia; BRCA cis rs4481887 0.893 rs6702113 chr1:248486151 T/C cg00666640 chr1:248458726 OR2T12 0.3 8.58 0.32 7.32e-17 Common traits (Other); BRCA cis rs7666738 0.687 rs6839454 chr4:99073914 T/C cg05340658 chr4:99064831 C4orf37 0.67 15.74 0.53 2.01e-47 Colonoscopy-negative controls vs population controls; BRCA cis rs1371614 0.635 rs12612619 chr2:27137671 C/T cg12368169 chr2:27073192 DPYSL5 -0.31 -9.16 -0.34 7.14e-19 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2204008 0.805 rs11514348 chr12:38243427 T/C cg26384229 chr12:38710491 ALG10B 0.75 16.96 0.56 1.52e-53 Bladder cancer; BRCA cis rs17818399 0.788 rs17818315 chr2:46818992 C/T cg02822958 chr2:46747628 ATP6V1E2 0.54 9.96 0.37 8.26e-22 Height; BRCA cis rs28595532 0.582 rs71608361 chr4:119224081 T/C cg21605333 chr4:119757512 SEC24D 0.81 8.48 0.32 1.58e-16 Cannabis dependence symptom count; BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.4e-19 Tonsillectomy; BRCA cis rs7640424 0.929 rs17828045 chr3:107821546 A/C cg09227934 chr3:107805635 CD47 -0.4 -8.34 -0.31 4.46e-16 Body mass index; BRCA cis rs34779708 0.966 rs12782948 chr10:35450607 G/A cg03585969 chr10:35415529 CREM 0.48 10.03 0.37 4.24e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6815814 0.851 rs17582893 chr4:38886420 G/A cg02016764 chr4:38805732 TLR1 -0.53 -8.49 -0.32 1.41e-16 Breast cancer; BRCA cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg04450456 chr4:17643702 FAM184B 0.38 11.4 0.41 1.55e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11764590 0.715 rs9969125 chr7:2088460 C/T cg25206134 chr2:45395956 NA 0.52 8.4 0.32 3e-16 Neuroticism; BRCA cis rs7264396 0.563 rs6060570 chr20:34291166 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.15 -0.43 1.1e-30 Total cholesterol levels; BRCA cis rs35110281 0.715 rs969060 chr21:45080852 T/G cg04455712 chr21:45112962 RRP1B 0.4 10.16 0.37 1.36e-22 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.32 0.61 7.31e-66 Alzheimer's disease; BRCA cis rs6582630 0.502 rs1607876 chr12:38355750 T/C cg13010199 chr12:38710504 ALG10B 0.45 9.4 0.35 9.42e-20 Drug-induced liver injury (flucloxacillin); BRCA trans rs3857536 0.785 rs1935895 chr6:66936606 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs7246967 0.673 rs2361260 chr19:22914144 C/T cg23217946 chr19:22817039 ZNF492 -0.5 -9.13 -0.34 9.02e-19 Bronchopulmonary dysplasia; BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg11814155 chr7:99998594 ZCWPW1 0.48 8.81 0.33 1.22e-17 Platelet count; BRCA cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg09184832 chr6:79620586 NA -0.41 -8.2 -0.31 1.35e-15 Intelligence (multi-trait analysis); BRCA cis rs586533 0.881 rs657055 chr11:99500087 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg11742103 chr11:62369870 EML3;MTA2 0.52 12.99 0.46 2.13e-34 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.24 0.59 3.67e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg10556349 chr10:835070 NA 0.6 8.41 0.32 2.75e-16 Eosinophil percentage of granulocytes; BRCA cis rs67311347 1.000 rs9860162 chr3:40403875 C/T cg09455208 chr3:40491958 NA 0.41 9.75 0.36 5.14e-21 Renal cell carcinoma; BRCA cis rs644148 0.781 rs630469 chr19:44970167 T/C cg15540054 chr19:45004280 ZNF180 -0.57 -12.05 -0.43 2.76e-30 Personality dimensions; BRCA cis rs875971 0.545 rs67775320 chr7:65658779 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 10.07 0.37 3.2e-22 Aortic root size; BRCA cis rs4689388 0.853 rs1079214 chr4:6282157 T/C cg25554036 chr4:6271136 WFS1 0.44 10.48 0.38 7.8e-24 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs62064224 0.553 rs9915115 chr17:30684858 A/G cg18200150 chr17:30822561 MYO1D 0.34 8.74 0.33 2.12e-17 Schizophrenia; BRCA cis rs66887589 0.837 rs7661498 chr4:120408108 T/C cg09307838 chr4:120376055 NA 0.47 9.76 0.36 4.59e-21 Diastolic blood pressure; BRCA cis rs8062405 0.737 rs11861132 chr16:28871860 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs12310956 0.510 rs7301767 chr12:33886529 A/T cg26384229 chr12:38710491 ALG10B 0.39 9.19 0.34 5.51e-19 Morning vs. evening chronotype; BRCA cis rs427394 0.582 rs4701751 chr5:6704137 C/T cg10857441 chr5:6722123 POLS -0.3 -9.23 -0.34 3.91e-19 Menopause (age at onset); BRCA trans rs4650994 1.000 rs10798617 chr1:178515806 T/C cg05059571 chr16:84539110 KIAA1609 -0.42 -9.6 -0.36 1.71e-20 HDL cholesterol levels;HDL cholesterol; BRCA trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21659725 chr3:3221576 CRBN -0.45 -9.45 -0.35 6.06e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4077515 0.967 rs3812558 chr9:139269135 A/G cg14019695 chr9:139328340 INPP5E 0.31 7.89 0.3 1.3e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9814567 1.000 rs3932818 chr3:134206069 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.18 -0.34 5.91e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17270561 0.609 rs4711095 chr6:25726774 A/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs11252926 0.574 rs4881313 chr10:487973 C/T cg16386425 chr10:429943 DIP2C 0.39 8.14 0.31 2.11e-15 Psychosis in Alzheimer's disease; BRCA cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg05347473 chr6:146136440 FBXO30 -0.6 -11.33 -0.41 3.05e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg06552810 chr11:31128660 NA -0.4 -8.92 -0.33 4.82e-18 Red blood cell count; BRCA cis rs17401966 0.838 rs1013952 chr1:10319247 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.7 0.48 1.21e-37 Hepatocellular carcinoma; BRCA cis rs2153535 0.580 rs1855769 chr6:8473095 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.62 0.39 2.24e-24 Motion sickness; BRCA cis rs12368653 1.000 rs12371356 chr12:58135420 T/C cg02175503 chr12:58329896 NA -0.38 -8.21 -0.31 1.21e-15 Multiple sclerosis; BRCA cis rs6005807 0.719 rs9625521 chr22:29039953 T/G cg12565055 chr22:29076175 TTC28 0.5 9.36 0.35 1.32e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg05863683 chr7:1912471 MAD1L1 0.38 8.34 0.31 4.67e-16 Schizophrenia; BRCA cis rs8177179 0.570 rs4441652 chr3:133439450 A/G cg24879335 chr3:133465180 TF 0.28 8.33 0.31 4.86e-16 Iron status biomarkers (transferrin levels); BRCA cis rs17741873 0.779 rs17631000 chr10:75602500 C/T cg07699608 chr10:75541558 CHCHD1 -0.51 -8.03 -0.3 4.62e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs6598955 0.671 rs11247908 chr1:26638222 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -8.13 -0.31 2.2e-15 Obesity-related traits; BRCA cis rs7666738 0.710 rs7674407 chr4:98838522 A/G cg17366294 chr4:99064904 C4orf37 0.43 9.94 0.37 9.93e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs965469 0.947 rs1854834 chr20:3376619 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.44 -0.38 1.12e-23 IFN-related cytopenia; BRCA cis rs3858526 0.883 rs10769326 chr11:5934358 C/T cg13902645 chr11:5959945 NA -0.54 -10.92 -0.4 1.4e-25 DNA methylation (variation); BRCA cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg17971929 chr21:40555470 PSMG1 0.77 17.94 0.58 1.35e-58 Cognitive function; BRCA cis rs11098499 0.657 rs9996569 chr4:120299004 G/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs4948102 0.924 rs13240915 chr7:56090752 G/C cg09872392 chr7:56161020 PHKG1 -0.4 -9.29 -0.34 2.42e-19 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7258465 1.000 rs28572537 chr19:18552208 C/T cg01065977 chr19:18549689 ISYNA1 -0.28 -8.38 -0.31 3.32e-16 Breast cancer; BRCA cis rs73086581 1.000 rs73088416 chr20:3995276 A/G cg02187196 chr20:3869020 PANK2 0.54 9.43 0.35 7.47e-20 Response to antidepressants in depression; BRCA cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg13010199 chr12:38710504 ALG10B 0.55 11.92 0.43 1e-29 Heart rate; BRCA cis rs4363385 0.747 rs1413848 chr1:152970210 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -8.01 -0.3 5.65e-15 Inflammatory skin disease; BRCA cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg02711726 chr17:80685570 FN3KRP 0.68 16.67 0.55 4.3e-52 Glycated hemoglobin levels; BRCA cis rs79976124 0.837 rs11751145 chr6:66642039 T/C cg07460842 chr6:66804631 NA 0.62 11.44 0.41 1.1e-27 Type 2 diabetes; BRCA cis rs270601 0.633 rs733300 chr5:131572243 A/G cg04518342 chr5:131593106 PDLIM4 0.38 8.78 0.33 1.48e-17 Acylcarnitine levels; BRCA cis rs11622475 1.000 rs1187448 chr14:104406627 C/T cg12183467 chr14:104352244 NA -0.48 -10.24 -0.38 6.99e-23 Bipolar disorder; BRCA cis rs13064411 0.696 rs6768648 chr3:113234141 C/G cg18753928 chr3:113234510 CCDC52 -0.59 -12.37 -0.44 1.15e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs68170813 0.559 rs12535081 chr7:106979291 C/T cg02696742 chr7:106810147 HBP1 -0.55 -8.69 -0.33 2.97e-17 Coronary artery disease; BRCA cis rs4819052 1.000 rs2297286 chr21:46707897 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 15.11 0.51 2.4e-44 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10911232 0.524 rs10911209 chr1:183013988 T/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.92 0.56 2.52e-53 Hypertriglyceridemia; BRCA cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg26384229 chr12:38710491 ALG10B 0.73 16.78 0.55 1.32e-52 Drug-induced liver injury (flucloxacillin); BRCA cis rs17376456 0.569 rs896729 chr5:93222178 A/G cg25358565 chr5:93447407 FAM172A -0.62 -10.92 -0.4 1.47e-25 Diabetic retinopathy; BRCA cis rs782590 1.000 rs782590 chr2:55843413 C/T cg18811423 chr2:55921094 PNPT1 0.72 22.21 0.66 2.03e-81 Metabolic syndrome; BRCA cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg01475377 chr6:109611718 NA -0.59 -16.46 -0.55 5.04e-51 Reticulocyte fraction of red cells; BRCA cis rs12541635 0.932 rs1835267 chr8:107044435 C/T cg10147462 chr8:107024639 NA 0.37 9.69 0.36 8.27e-21 Age of smoking initiation; BRCA cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg00684032 chr4:1343700 KIAA1530 0.51 12.28 0.44 3.01e-31 Obesity-related traits; BRCA cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg24642439 chr20:33292090 TP53INP2 0.61 13.64 0.47 2.22e-37 Coronary artery disease; BRCA cis rs595982 0.517 rs10404905 chr19:49406175 A/T cg21252483 chr19:49399788 TULP2 0.27 8.48 0.32 1.57e-16 Red cell distribution width; BRCA cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg06784218 chr1:46089804 CCDC17 0.51 12.48 0.44 4.02e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs68170813 0.559 rs12537342 chr7:106943563 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.64 -0.32 4.46e-17 Coronary artery disease; BRCA cis rs17376456 1.000 rs58734583 chr5:93532155 C/T cg25358565 chr5:93447407 FAM172A 1.16 18.69 0.59 1.7e-62 Diabetic retinopathy; BRCA cis rs1862618 0.671 rs2591966 chr5:56233688 T/G cg18230493 chr5:56204884 C5orf35 0.6 12.85 0.45 8.8e-34 Initial pursuit acceleration; BRCA cis rs10267417 0.603 rs9638768 chr7:19869522 C/T cg05791153 chr7:19748676 TWISTNB -0.45 -8.42 -0.32 2.56e-16 Night sleep phenotypes; BRCA cis rs2425143 1.000 rs60646509 chr20:34303409 T/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA trans rs61931739 0.500 rs10844789 chr12:34202279 C/G cg13010199 chr12:38710504 ALG10B 0.49 9.53 0.35 3.12e-20 Morning vs. evening chronotype; BRCA cis rs7727544 0.582 rs10052046 chr5:131544466 G/T cg14196790 chr5:131705035 SLC22A5 0.36 9.15 0.34 7.58e-19 Blood metabolite levels; BRCA cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg22906224 chr7:99728672 NA 0.44 8.46 0.32 1.87e-16 Coronary artery disease; BRCA cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -8.94 -0.33 4.31e-18 Mood instability; BRCA cis rs13046373 0.508 rs2253516 chr21:31993317 C/T cg14062083 chr21:31802829 KRTAP13-4 0.34 9.14 0.34 8.23e-19 HDL cholesterol; BRCA cis rs3806843 1.000 rs991918 chr5:140194858 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.86 -0.36 1.89e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg19318889 chr4:1322082 MAEA -0.48 -10.05 -0.37 3.77e-22 Obesity-related traits; BRCA trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -14.18 -0.49 7.04e-40 Extrinsic epigenetic age acceleration; BRCA cis rs2625529 0.652 rs2929518 chr15:72332748 A/C cg16672083 chr15:72433130 SENP8 0.67 16.21 0.54 9.08e-50 Red blood cell count; BRCA cis rs1355223 0.583 rs1396881 chr11:34870506 G/T cg11058730 chr11:34937778 PDHX;APIP 0.67 15.55 0.52 1.82e-46 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs4975616 0.869 rs421284 chr5:1325590 T/C cg07493874 chr5:1342172 CLPTM1L -0.51 -14.7 -0.5 2.43e-42 Lung cancer; BRCA cis rs4563143 0.663 rs10417671 chr19:29235335 T/C cg04546413 chr19:29218101 NA 0.61 12.5 0.44 3.15e-32 Methadone dose in opioid dependence; BRCA cis rs3768617 0.510 rs3768621 chr1:183090057 C/T ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA cis rs61931739 0.534 rs10844732 chr12:34037104 A/C cg06521331 chr12:34319734 NA -0.62 -11.16 -0.4 1.46e-26 Morning vs. evening chronotype; BRCA cis rs796364 0.951 rs7586284 chr2:201068002 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 8.36 0.31 3.97e-16 Schizophrenia; BRCA cis rs9291683 0.620 rs4383618 chr4:10125151 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -9.9 -0.36 1.32e-21 Bone mineral density; BRCA cis rs7582180 0.663 rs6542930 chr2:100944383 T/A cg14675211 chr2:100938903 LONRF2 0.43 9.86 0.36 1.89e-21 Intelligence (multi-trait analysis); BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg18758796 chr5:131593413 PDLIM4 0.36 9.34 0.35 1.63e-19 Breast cancer; BRCA cis rs7043114 0.525 rs2025388 chr9:95128740 T/C cg14631576 chr9:95140430 CENPP -0.34 -8.39 -0.31 3.16e-16 Height; BRCA cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg06552810 chr11:31128660 NA -0.39 -8.65 -0.32 4.19e-17 Red blood cell count; BRCA cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs67478160 0.619 rs11160759 chr14:104231542 C/T cg26031613 chr14:104095156 KLC1 -0.42 -8.54 -0.32 1e-16 Schizophrenia; BRCA cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg06618935 chr21:46677482 NA -0.35 -8.02 -0.3 5.04e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs61931739 0.534 rs11053000 chr12:34079022 C/T cg06521331 chr12:34319734 NA -0.59 -10.7 -0.39 1.13e-24 Morning vs. evening chronotype; BRCA cis rs1371614 0.679 rs4441421 chr2:27142091 G/A cg00617064 chr2:27272375 NA -0.3 -7.86 -0.3 1.6e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9682041 0.808 rs9875109 chr3:170064776 A/G cg11886554 chr3:170076028 SKIL -0.49 -9.78 -0.36 3.78e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA trans rs11098499 0.754 rs714899 chr4:120243035 G/A cg25214090 chr10:38739885 LOC399744 0.46 10.44 0.38 1.13e-23 Corneal astigmatism; BRCA cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg06453172 chr10:134556979 INPP5A -0.47 -10.36 -0.38 2.43e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.02 15.31 0.52 2.64e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4845570 1.000 rs11585294 chr1:151769887 A/C cg07092448 chr1:151763213 TDRKH -0.95 -16.17 -0.54 1.54e-49 Coronary artery disease; BRCA cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg20573242 chr4:122745356 CCNA2 0.49 10.86 0.39 2.41e-25 Type 2 diabetes; BRCA cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg12386194 chr3:101231763 SENP7 0.45 9.6 0.35 1.79e-20 Colorectal cancer; BRCA cis rs12618769 0.656 rs56091613 chr2:99103761 A/G cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs1209950 0.866 rs1734588 chr21:40180889 A/G cg01359822 chr21:40176597 ETS2 0.35 8.59 0.32 6.89e-17 Non-small cell lung cancer (survival); BRCA cis rs1707322 0.963 rs12145287 chr1:46325002 C/G cg06784218 chr1:46089804 CCDC17 0.49 11.66 0.42 1.26e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504073 0.565 rs974780 chr8:49930976 G/A cg00325661 chr8:49890786 NA 0.54 15.54 0.52 1.89e-46 Blood metabolite ratios; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg22907277 chr7:1156413 C7orf50 0.53 11.52 0.41 5.09e-28 Longevity;Endometriosis; BRCA cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg08219700 chr8:58056026 NA 0.47 8.61 0.32 5.68e-17 Developmental language disorder (linguistic errors); BRCA cis rs10193935 1.000 rs10193935 chr2:42419829 C/T cg27598129 chr2:42591480 NA -0.87 -14.24 -0.49 3.5e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.501 rs35526119 chr3:52749334 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.45e-19 Bipolar disorder; BRCA cis rs4363385 0.818 rs10888524 chr1:153000125 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.01 -0.34 2.29e-18 Inflammatory skin disease; BRCA cis rs8114671 0.836 rs17404569 chr20:33674077 A/C cg24642439 chr20:33292090 TP53INP2 -0.44 -8.82 -0.33 1.12e-17 Height; BRCA cis rs2882667 0.690 rs6860780 chr5:138160056 A/G cg04439458 chr5:138467593 SIL1 0.31 7.82 0.3 2.23e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg08999081 chr20:33150536 PIGU -0.44 -12.06 -0.43 2.68e-30 Glomerular filtration rate (creatinine); BRCA cis rs1801251 0.685 rs1515961 chr2:233623763 C/A cg08000102 chr2:233561755 GIGYF2 0.64 14.75 0.5 1.43e-42 Coronary artery disease; BRCA cis rs12210905 0.610 rs12204953 chr6:27396737 G/A cg08851530 chr6:28072375 NA 0.81 7.94 0.3 8.95e-15 Hip circumference adjusted for BMI; BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg22903471 chr2:27725779 GCKR -0.35 -8.4 -0.32 2.79e-16 Menopause (age at onset); BRCA cis rs2011503 1.000 rs61744761 chr19:19656615 C/T cg15839431 chr19:19639596 YJEFN3 -0.43 -9.16 -0.34 6.76e-19 Bipolar disorder; BRCA cis rs708547 0.915 rs28605409 chr4:57766261 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.47 10.87 0.39 2.33e-25 Response to bleomycin (chromatid breaks); BRCA trans rs1973993 0.689 rs17131755 chr1:96886167 G/A cg10631902 chr5:14652156 NA -0.45 -12.52 -0.44 2.49e-32 Weight; BRCA cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11890956 chr21:40555474 PSMG1 -0.62 -13.75 -0.48 6.99e-38 Menarche (age at onset); BRCA cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg10932868 chr11:921992 NA 0.39 9.52 0.35 3.6e-20 Alzheimer's disease (late onset); BRCA cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA trans rs7824557 0.606 rs1435277 chr8:11196970 C/T cg06636001 chr8:8085503 FLJ10661 0.5 11.06 0.4 3.79e-26 Retinal vascular caliber; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -13.22 -0.46 1.85e-35 Platelet count; BRCA cis rs758324 0.947 rs1500115 chr5:131216427 G/T cg06307176 chr5:131281290 NA 0.52 10.01 0.37 5.18e-22 Alzheimer's disease in APOE e4- carriers; BRCA trans rs9291683 0.552 rs17187075 chr4:9990328 G/C cg26043149 chr18:55253948 FECH 0.4 8.77 0.33 1.59e-17 Bone mineral density; BRCA cis rs2320614 0.967 rs12500406 chr4:164034998 C/A cg15586945 chr4:164088095 NAF1 -0.4 -8.08 -0.3 3.35e-15 Lung adenocarcinoma; BRCA cis rs12701220 0.522 rs1881116 chr7:1053958 C/T cg26769984 chr7:1090371 C7orf50 0.43 9.13 0.34 8.76e-19 Bronchopulmonary dysplasia; BRCA cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg11833968 chr6:79620685 NA -0.44 -9.76 -0.36 4.58e-21 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg06238570 chr21:40685208 BRWD1 -0.39 -7.86 -0.3 1.69e-14 Menarche (age at onset); BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg15112475 chr7:1198522 ZFAND2A -0.56 -13.83 -0.48 2.95e-38 Longevity;Endometriosis; BRCA cis rs754466 0.651 rs11813532 chr10:79637991 T/C cg17075019 chr10:79541650 NA -0.73 -17.61 -0.57 7.05e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9325144 0.555 rs1813392 chr12:38692203 C/T cg26384229 chr12:38710491 ALG10B -0.54 -13.8 -0.48 4.04e-38 Morning vs. evening chronotype; BRCA cis rs875971 0.545 rs316305 chr7:65617971 G/A cg11764359 chr7:65958608 NA -0.66 -12.12 -0.43 1.34e-30 Aortic root size; BRCA cis rs7100689 0.646 rs10400045 chr10:82077032 A/G cg01528321 chr10:82214614 TSPAN14 0.81 17.1 0.56 2.94e-54 Post bronchodilator FEV1; BRCA cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg13010199 chr12:38710504 ALG10B 0.59 12.95 0.46 3.28e-34 Heart rate; BRCA cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg21132104 chr15:45694354 SPATA5L1 0.7 15.45 0.52 5.52e-46 Homoarginine levels; BRCA cis rs7927771 0.524 rs7107792 chr11:47669249 A/C cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.42e-20 Subjective well-being; BRCA cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg11301795 chr4:187892539 NA -0.26 -9.01 -0.34 2.44e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4689388 0.926 rs4308429 chr4:6294001 A/G cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 11.12 0.4 2.13e-26 Rheumatoid arthritis; BRCA cis rs3845702 0.736 rs6433821 chr2:180837806 T/A cg01881094 chr2:180872142 CWC22 -1.04 -18.5 -0.59 1.71e-61 Schizophrenia; BRCA cis rs6087990 0.735 rs2424913 chr20:31374259 C/T cg13636640 chr20:31349939 DNMT3B 0.55 15.54 0.52 2e-46 Ulcerative colitis; BRCA cis rs6910061 0.830 rs13203123 chr6:11103491 T/C cg27233058 chr6:11094804 LOC221710 0.5 8.48 0.32 1.6e-16 Diabetic kidney disease; BRCA cis rs67460515 0.892 rs4856769 chr3:161004549 C/A cg04691961 chr3:161091175 C3orf57 -0.39 -8.15 -0.31 1.92e-15 Parkinson's disease; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg18402987 chr7:1209562 NA 0.83 11.81 0.42 2.85e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7312933 0.618 rs7315968 chr12:42637086 G/A cg01256987 chr12:42539512 GXYLT1 -0.4 -8.01 -0.3 5.61e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.41 0.5 5.45e-41 Motion sickness; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA trans rs1005277 0.540 rs2224248 chr10:38451886 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 4.14e-39 Extrinsic epigenetic age acceleration; BRCA cis rs7474896 0.583 rs7071147 chr10:38003376 T/C cg25427524 chr10:38739819 LOC399744 -0.55 -10.1 -0.37 2.31e-22 Obesity (extreme); BRCA cis rs7560272 0.538 rs3980695 chr2:73939552 A/G cg20560298 chr2:73613845 ALMS1 0.35 8.92 0.33 4.77e-18 Schizophrenia; BRCA cis rs1113500 0.787 rs473704 chr1:108637310 T/C cg06207961 chr1:108661230 NA -0.36 -8.85 -0.33 8.71e-18 Growth-regulated protein alpha levels; BRCA cis rs8072100 0.676 rs9908049 chr17:45502096 G/C cg25173405 chr17:45401733 C17orf57 -0.52 -10.88 -0.4 2.1e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg22467129 chr15:76604101 ETFA -0.48 -10.49 -0.38 7.16e-24 Blood metabolite levels; BRCA cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg06159980 chr1:16340746 HSPB7 -0.38 -7.85 -0.3 1.81e-14 Dilated cardiomyopathy; BRCA cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg06221963 chr1:154839813 KCNN3 -0.59 -16.62 -0.55 8.53e-52 Prostate cancer; BRCA trans rs208520 0.690 rs12208310 chr6:66730108 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.98 20.55 0.63 2.12e-72 Exhaled nitric oxide output; BRCA cis rs3772130 1.000 rs35988617 chr3:121432902 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.65 0.36 1.16e-20 Cognitive performance; BRCA cis rs4268898 1.000 rs10195436 chr2:24436112 C/T cg06627628 chr2:24431161 ITSN2 0.49 10.07 0.37 3.11e-22 Asthma; BRCA trans rs1422110 0.543 rs888804 chr5:85411181 G/A cg01787110 chr1:109008453 NBPF6 0.48 10.61 0.39 2.51e-24 Attention function in attention deficit hyperactive disorder; BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg21782813 chr7:2030301 MAD1L1 0.33 8.95 0.33 3.96e-18 Schizophrenia; BRCA cis rs7617773 0.780 rs3731550 chr3:48206583 A/C cg11946769 chr3:48343235 NME6 0.68 13.82 0.48 3.24e-38 Coronary artery disease; BRCA cis rs10791323 0.572 rs10894755 chr11:133739685 C/T cg06766960 chr11:133703094 NA 0.53 11.42 0.41 1.31e-27 Childhood ear infection; BRCA cis rs72781680 0.821 rs72790304 chr2:24108557 G/A cg08917208 chr2:24149416 ATAD2B 0.7 11.5 0.41 5.72e-28 Lymphocyte counts; BRCA trans rs2018683 0.870 rs13232487 chr7:28985119 C/A cg19402173 chr7:128379420 CALU -0.49 -12.41 -0.44 7.87e-32 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs4845570 0.831 rs11588634 chr1:151780686 T/A cg07092448 chr1:151763213 TDRKH -0.77 -12.7 -0.45 4.15e-33 Coronary artery disease; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00149659 chr3:10157352 C3orf10 0.8 14.11 0.49 1.53e-39 Alzheimer's disease; BRCA cis rs11605275 1.000 rs78249104 chr11:20027680 G/T cg14835545 chr11:20032148 NAV2 -0.63 -8.98 -0.33 2.91e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.09 0.3 3.08e-15 Aortic root size; BRCA cis rs490234 0.676 rs13299008 chr9:128213966 T/G cg14078157 chr9:128172775 NA -0.53 -11.39 -0.41 1.76e-27 Mean arterial pressure; BRCA cis rs7044106 0.791 rs747819 chr9:123488441 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 15.72 0.53 2.63e-47 Hip circumference adjusted for BMI; BRCA cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg26818010 chr10:134567672 INPP5A -0.69 -14.44 -0.5 4.23e-41 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg24558204 chr6:135376177 HBS1L 0.59 15.94 0.53 1.98e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg08999081 chr20:33150536 PIGU 0.32 7.97 0.3 7.11e-15 Coronary artery disease; BRCA cis rs4595586 0.545 rs4142846 chr12:39395140 C/T cg26384229 chr12:38710491 ALG10B 0.37 8.15 0.31 1.87e-15 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs1185976 chr6:25822363 A/G cg16482183 chr6:26056742 HIST1H1C -0.43 -9.28 -0.34 2.5e-19 Iron status biomarkers; BRCA cis rs6089829 0.851 rs6122346 chr20:61661822 C/G cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs9393777 0.623 rs16891717 chr6:26477143 T/A cg12826209 chr6:26865740 GUSBL1 0.56 9.23 0.34 3.92e-19 Intelligence (multi-trait analysis); BRCA cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg18876405 chr7:65276391 NA 0.62 15.24 0.52 5.52e-45 Aortic root size; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg14062083 chr21:31802829 KRTAP13-4 0.35 9.54 0.35 3.04e-20 HDL cholesterol; BRCA cis rs7904985 0.961 rs12355013 chr10:88114538 A/G cg07322936 chr10:88137208 NA 0.39 7.97 0.3 7.16e-15 Barrett's esophagus; BRCA cis rs11955398 0.716 rs1379117 chr5:59942309 T/C cg02684056 chr5:59996105 DEPDC1B 0.38 9.13 0.34 8.69e-19 Intelligence (multi-trait analysis); BRCA cis rs528301 0.613 rs4953143 chr2:45124291 C/G cg02372786 chr2:45167549 SIX3 0.43 9.35 0.35 1.46e-19 Alcohol and nicotine co-dependence; BRCA cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg12311346 chr5:56204834 C5orf35 0.44 8.78 0.33 1.53e-17 Coronary artery disease; BRCA cis rs992157 0.767 rs2382822 chr2:219173327 T/C cg00012203 chr2:219082015 ARPC2 -0.45 -8.75 -0.33 1.86e-17 Colorectal cancer; BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg22963979 chr7:1858916 MAD1L1 -0.46 -9.21 -0.34 4.69e-19 Bipolar disorder and schizophrenia; BRCA cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg18200150 chr17:30822561 MYO1D 0.35 8.91 0.33 5.17e-18 Schizophrenia; BRCA cis rs698833 0.892 rs1067363 chr2:44658401 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.87 0.36 1.78e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs10162002 1.000 rs10162002 chr13:24042510 G/A cg00158254 chr13:24040743 NA 0.57 9.34 0.35 1.51e-19 Hypothyroidism; BRCA cis rs2070433 0.500 rs9306156 chr21:47960493 T/C cg12379764 chr21:47803548 PCNT 0.46 10.29 0.38 4.32e-23 Lymphocyte counts; BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs7851660 0.933 rs894673 chr9:100612270 A/T cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.81e-17 Strep throat; BRCA cis rs7246657 0.525 rs10401417 chr19:37467540 C/T cg23950597 chr19:37808831 NA -0.59 -9.39 -0.35 1.06e-19 Coronary artery calcification; BRCA cis rs7582180 0.764 rs11683121 chr2:100920705 C/T cg14675211 chr2:100938903 LONRF2 0.47 10.74 0.39 7.85e-25 Intelligence (multi-trait analysis); BRCA trans rs2562456 0.917 rs2562471 chr19:21715819 C/T cg25042112 chr7:64838748 ZNF92 0.46 8.51 0.32 1.27e-16 Pain; BRCA cis rs11122272 0.735 rs2486743 chr1:231506928 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.51 -12.3 -0.44 2.33e-31 Hemoglobin concentration; BRCA cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg05347473 chr6:146136440 FBXO30 0.42 8.27 0.31 7.91e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.704 rs7787753 chr7:148901779 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.42 8.48 0.32 1.57e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2742234 0.541 rs60845448 chr10:43721462 C/T cg15436174 chr10:43711423 RASGEF1A 0.53 10.6 0.39 2.8e-24 Hirschsprung disease; BRCA cis rs9487051 0.807 rs7748641 chr6:109592381 C/T cg12927641 chr6:109611667 NA -0.41 -10.56 -0.39 3.79e-24 Reticulocyte fraction of red cells; BRCA cis rs832540 0.564 rs33329 chr5:56145068 T/C cg12311346 chr5:56204834 C5orf35 -0.47 -9.81 -0.36 2.83e-21 Coronary artery disease; BRCA cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg12927641 chr6:109611667 NA -0.4 -10.39 -0.38 1.88e-23 Reticulocyte fraction of red cells; BRCA cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg03560586 chr2:239334908 ASB1 -0.41 -7.87 -0.3 1.55e-14 Multiple system atrophy; BRCA cis rs7254114 0.578 rs7246614 chr19:11310538 C/T cg02815516 chr19:11306319 KANK2 -0.35 -10.02 -0.37 4.8e-22 Immature fraction of reticulocytes; BRCA cis rs6060717 0.536 rs6058364 chr20:34507890 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.12 -0.31 2.41e-15 Hip circumference adjusted for BMI; BRCA cis rs6460942 1.000 rs75564554 chr7:12319362 A/C cg06484146 chr7:12443880 VWDE -0.62 -8.57 -0.32 7.55e-17 Coronary artery disease; BRCA cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg27279351 chr12:120934652 DYNLL1 0.57 13.5 0.47 1.05e-36 High light scatter reticulocyte count; BRCA cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg17211192 chr8:82754475 SNX16 -0.56 -10.57 -0.39 3.54e-24 Diastolic blood pressure; BRCA cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg22903471 chr2:27725779 GCKR -0.34 -8.13 -0.31 2.25e-15 Total body bone mineral density; BRCA cis rs10992471 0.528 rs7037194 chr9:95216745 G/A cg14631576 chr9:95140430 CENPP -0.35 -8.69 -0.33 3.04e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs6813479 0.594 rs1031711 chr4:137737358 A/C cg16185213 chr4:137733633 NA 0.4 9.46 0.35 5.86e-20 Longevity; BRCA cis rs910316 0.712 rs175037 chr14:75465038 T/C cg11812906 chr14:75593930 NEK9 -0.63 -14.62 -0.5 5.46e-42 Height; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -13.52 -0.47 8.46e-37 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.34e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs1638734 chr7:66097539 A/C cg18252515 chr7:66147081 NA -1.06 -15.57 -0.52 1.48e-46 Diabetic kidney disease; BRCA cis rs9467773 0.620 rs9461276 chr6:26595168 T/C cg11502198 chr6:26597334 ABT1 0.58 12.52 0.44 2.58e-32 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.897 rs2776308 chr21:40715175 A/G cg17971929 chr21:40555470 PSMG1 0.72 15.88 0.53 4.35e-48 Cognitive function; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg12379764 chr21:47803548 PCNT 0.37 7.82 0.3 2.2e-14 Testicular germ cell tumor; BRCA cis rs1400816 1.000 rs1400816 chr2:172680678 A/C cg13550731 chr2:172543902 DYNC1I2 -0.52 -7.86 -0.3 1.68e-14 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2637030 0.559 rs370594 chr5:52955554 C/T cg06476337 chr5:52856530 NDUFS4 0.35 7.92 0.3 1.03e-14 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs1005277 0.579 rs1740737 chr10:38499365 G/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.18 -0.58 7.43e-60 Extrinsic epigenetic age acceleration; BRCA cis rs1801251 1.000 rs4973055 chr2:233720283 G/T cg08000102 chr2:233561755 GIGYF2 -0.62 -13.45 -0.47 1.7e-36 Coronary artery disease; BRCA cis rs3008870 1.000 rs1137656 chr1:67451602 A/C cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs1153858 1.000 rs4774579 chr15:45651803 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.64 0.42 1.55e-28 Homoarginine levels; BRCA cis rs11098499 0.780 rs7680914 chr4:120563053 A/G cg09307838 chr4:120376055 NA 0.67 13.39 0.47 3.26e-36 Corneal astigmatism; BRCA cis rs950776 0.684 rs11637635 chr15:78877150 A/G cg06917634 chr15:78832804 PSMA4 -0.58 -12.45 -0.44 5.35e-32 Sudden cardiac arrest; BRCA cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg00684032 chr4:1343700 KIAA1530 0.32 7.96 0.3 7.86e-15 Obesity-related traits; BRCA cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg19628046 chr18:33552617 C18orf21 0.56 11.62 0.42 1.89e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9308433 0.529 rs904321 chr1:214506550 G/C cg06198575 chr1:214491504 SMYD2 0.58 12.6 0.45 1.17e-32 IgG glycosylation; BRCA cis rs453301 0.658 rs3855900 chr8:8901921 A/G cg15556689 chr8:8085844 FLJ10661 -0.36 -9.67 -0.36 1.01e-20 Joint mobility (Beighton score); BRCA cis rs6582630 0.638 rs35864536 chr12:38472255 T/A cg26384229 chr12:38710491 ALG10B -0.43 -9.88 -0.36 1.65e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs9914988 0.943 rs9915673 chr17:27132893 G/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7560272 0.538 rs11126415 chr2:73936500 C/T cg20560298 chr2:73613845 ALMS1 0.34 8.96 0.33 3.56e-18 Schizophrenia; BRCA trans rs12406019 0.510 rs2025614 chr1:78618151 G/A cg20826526 chr3:156266748 SSR3 -0.38 -8.14 -0.31 2.01e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs9329289 0.603 rs2458705 chr10:2541377 A/G cg15501526 chr10:2543763 NA 0.55 12.88 0.45 6.66e-34 Age-related hearing impairment; BRCA cis rs1577917 1.000 rs4707239 chr6:86610717 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.43 -0.41 1.22e-27 Response to antipsychotic treatment; BRCA trans rs3733585 0.699 rs4515163 chr4:9959603 C/T cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg09436375 chr6:42928200 GNMT -0.3 -10.86 -0.39 2.5e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9787249 0.957 rs7548120 chr1:40204424 A/T cg02773041 chr1:40204384 PPIE 0.46 9.66 0.36 1.06e-20 Blood protein levels; BRCA cis rs6782228 0.606 rs2811500 chr3:128366256 C/T cg16766828 chr3:128327626 NA -0.43 -9.67 -0.36 9.86e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs4900538 0.855 rs12587464 chr14:102886561 G/C cg18135206 chr14:102964638 TECPR2 -0.89 -20.89 -0.64 2.86e-74 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs1941687 0.563 rs1586987 chr18:31338661 A/G cg27147174 chr7:100797783 AP1S1 -0.42 -8.59 -0.32 6.4e-17 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg16339924 chr4:17578868 LAP3 0.63 15.68 0.53 4.2e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs775227 0.574 rs16861158 chr3:113261709 G/T cg18753928 chr3:113234510 CCDC52 -0.57 -9.58 -0.35 2.02e-20 Dental caries; BRCA cis rs6121246 0.559 rs6058468 chr20:30406448 C/A cg21427119 chr20:30132790 HM13 -0.35 -8.04 -0.3 4.25e-15 Mean corpuscular hemoglobin; BRCA cis rs7178424 1.000 rs8038932 chr15:62364257 T/C cg00456672 chr15:62358751 C2CD4A -0.34 -8.18 -0.31 1.49e-15 Height; BRCA cis rs17401966 0.931 rs4846213 chr1:10399178 A/G cg03954927 chr1:10346856 KIF1B 0.48 15.23 0.52 6.45e-45 Hepatocellular carcinoma; BRCA cis rs2011503 1.000 rs76790018 chr19:19652157 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.49 0.44 3.42e-32 Bipolar disorder; BRCA trans rs12458462 0.892 rs12456692 chr18:77482189 C/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -8.75 -0.33 1.82e-17 Monocyte count; BRCA cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg09580153 chr6:41068724 NFYA;LOC221442 0.37 7.84 0.3 1.85e-14 Alzheimer's disease (late onset); BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg08067268 chr2:26466485 HADHB;HADHA 0.57 10.25 0.38 6.18e-23 Gut microbiome composition (summer); BRCA cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg13393036 chr8:95962371 TP53INP1 -0.3 -8.07 -0.3 3.54e-15 Type 2 diabetes; BRCA trans rs561341 1.000 rs4795669 chr17:30244701 C/T cg27661571 chr11:113659931 NA -0.76 -11.7 -0.42 8.85e-29 Hip circumference adjusted for BMI; BRCA cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg04733989 chr22:42467013 NAGA 0.58 13.01 0.46 1.7e-34 Schizophrenia; BRCA cis rs1421811 0.606 rs62369523 chr5:32713365 T/G cg16267343 chr5:32710456 NPR3 0.7 12.91 0.45 4.86e-34 Blood pressure; BRCA cis rs4566357 0.615 rs4675139 chr2:227908527 G/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.37 -0.35 1.23e-19 Coronary artery disease; BRCA cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs36051895 0.659 rs10974944 chr9:5070831 C/G cg02405213 chr9:5042618 JAK2 -0.51 -9.23 -0.34 3.82e-19 Pediatric autoimmune diseases; BRCA cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.78 0.33 1.45e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9868809 0.505 rs11719291 chr3:48735706 A/G cg07636037 chr3:49044803 WDR6 -0.6 -8.95 -0.33 3.94e-18 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7727544 0.582 rs6896703 chr5:131521295 C/G cg14196790 chr5:131705035 SLC22A5 -0.38 -9.34 -0.35 1.61e-19 Blood metabolite levels; BRCA cis rs12701220 0.503 rs13222294 chr7:1172969 G/A cg00990874 chr7:1149470 C7orf50 -0.57 -10.56 -0.39 3.87e-24 Bronchopulmonary dysplasia; BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg04944784 chr2:26401820 FAM59B -0.94 -17.09 -0.56 3.34e-54 Gut microbiome composition (summer); BRCA cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.72e-31 Blood protein levels; BRCA cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg10295955 chr4:187884368 NA 0.95 29.09 0.75 4.11e-119 Lobe attachment (rater-scored or self-reported); BRCA cis rs11190604 1.000 rs11292 chr10:102313607 A/G cg07080220 chr10:102295463 HIF1AN 0.58 13.7 0.48 1.27e-37 Palmitoleic acid (16:1n-7) levels; BRCA cis rs3862260 0.509 rs7552885 chr1:120164966 C/T cg11530693 chr1:120165357 ZNF697 0.62 14.94 0.51 1.68e-43 Systemic lupus erythematosus; BRCA cis rs3733585 0.673 rs4519796 chr4:9955936 A/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.39 -0.38 1.72e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg00074818 chr8:8560427 CLDN23 0.36 8.07 0.3 3.47e-15 Obesity-related traits; BRCA cis rs4713118 0.955 rs9393848 chr6:27688369 C/T cg26587870 chr6:27730563 NA -0.37 -7.89 -0.3 1.34e-14 Parkinson's disease; BRCA cis rs7264396 0.790 rs6060565 chr20:34285442 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.16 0.31 1.82e-15 Total cholesterol levels; BRCA cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.71 -0.33 2.55e-17 Colorectal cancer; BRCA cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs66887589 0.592 rs11731571 chr4:120221185 G/A cg09307838 chr4:120376055 NA 0.48 10.22 0.37 8e-23 Diastolic blood pressure; BRCA cis rs6700896 0.931 rs79050868 chr1:66120916 G/A cg04111102 chr1:66153794 NA 0.36 8.86 0.33 7.9e-18 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs9793167 chr1:46446800 G/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3981351 0.528 rs12768908 chr10:115443894 C/T cg24846397 chr10:115438155 CASP7 -0.35 -8.28 -0.31 7.15e-16 Obesity-related traits; BRCA trans rs66887589 0.592 rs2175383 chr4:120215836 C/A cg25214090 chr10:38739885 LOC399744 0.37 8.53 0.32 1.09e-16 Diastolic blood pressure; BRCA cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg06552810 chr11:31128660 NA -0.39 -8.69 -0.33 3.06e-17 Red blood cell count; BRCA cis rs9807989 0.507 rs2110659 chr2:103043867 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma; BRCA cis rs2016266 0.826 rs61928079 chr12:53741468 T/C cg26875137 chr12:53738046 NA -0.44 -9.7 -0.36 7.59e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs1355223 0.506 rs1509659 chr11:34865133 A/G cg11058730 chr11:34937778 PDHX;APIP -0.49 -9.5 -0.35 4.21e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs1422110 0.616 rs1862230 chr5:85444868 C/T cg01787110 chr1:109008453 NBPF6 -0.41 -8.47 -0.32 1.7e-16 Attention function in attention deficit hyperactive disorder; BRCA cis rs6066835 1.000 rs6066835 chr20:47355009 A/G cg18078177 chr20:47281410 PREX1 0.64 8.87 0.33 7.57e-18 Multiple myeloma; BRCA cis rs8114671 0.805 rs6060168 chr20:33621017 C/T cg24642439 chr20:33292090 TP53INP2 0.42 8.71 0.33 2.52e-17 Height; BRCA cis rs10464366 0.912 rs7785889 chr7:39106368 G/T cg18850127 chr7:39170497 POU6F2 0.43 8.87 0.33 7.22e-18 IgG glycosylation; BRCA cis rs3772130 0.962 rs4413346 chr3:121486310 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.61 0.39 2.56e-24 Cognitive performance; BRCA cis rs2011503 1.000 rs77427798 chr19:19652982 T/C cg11584989 chr19:19387371 SF4 0.62 13.0 0.46 1.89e-34 Bipolar disorder; BRCA cis rs10411936 0.720 rs4808513 chr19:16580498 G/C cg10248733 chr19:16607483 C19orf44;CALR3 0.45 9.62 0.36 1.48e-20 White blood cell count;Multiple sclerosis; BRCA cis rs758324 0.898 rs510434 chr5:131292503 C/T cg06307176 chr5:131281290 NA -0.54 -10.43 -0.38 1.24e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg13010199 chr12:38710504 ALG10B 0.45 8.94 0.33 4.06e-18 Morning vs. evening chronotype; BRCA cis rs74417235 0.517 rs13179034 chr5:154059487 C/A cg07371521 chr5:154026371 NA 0.42 8.13 0.31 2.25e-15 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg27170947 chr2:26402098 FAM59B -0.81 -15.26 -0.52 4.63e-45 Gut microbiome composition (summer); BRCA cis rs9290065 0.519 rs6774203 chr3:160705217 G/T cg03342759 chr3:160939853 NMD3 -0.46 -9.48 -0.35 5.04e-20 Kawasaki disease; BRCA cis rs3733585 0.648 rs35954357 chr4:9978758 G/C cg00071950 chr4:10020882 SLC2A9 0.43 9.94 0.37 9.89e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs8073060 0.559 rs17550632 chr17:33890883 G/C cg19694781 chr19:47549865 TMEM160 1.06 21.79 0.65 3.65e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2243480 0.803 rs34004500 chr7:65312178 A/T cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -8.67 -0.32 3.43e-17 Glomerular filtration rate (creatinine); BRCA cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg01579765 chr21:45077557 HSF2BP 0.41 10.63 0.39 2.09e-24 Mean corpuscular volume; BRCA cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg05623727 chr3:50126028 RBM5 -0.42 -10.06 -0.37 3.32e-22 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.563 rs4428546 chr6:8490376 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.67 0.39 1.36e-24 Motion sickness; BRCA cis rs400736 1.000 rs400736 chr1:8078309 T/C cg25007680 chr1:8021821 PARK7 0.47 11.89 0.43 1.43e-29 Response to antidepressants and depression; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg25036284 chr2:26402008 FAM59B -0.95 -15.47 -0.52 4.27e-46 Gut microbiome composition (summer); BRCA cis rs6582630 0.519 rs1851130 chr12:38507819 C/T cg13010199 chr12:38710504 ALG10B 0.49 10.46 0.38 9.44e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs7119 0.717 rs16968835 chr15:77734261 G/A cg17802220 chr15:77601643 NA -0.43 -9.93 -0.37 1.09e-21 Type 2 diabetes; BRCA cis rs1801251 0.778 rs778338 chr2:233740227 A/G cg25237894 chr2:233734115 C2orf82 -0.44 -13.92 -0.48 1.12e-38 Coronary artery disease; BRCA cis rs10504229 0.953 rs116564484 chr8:58172818 T/C cg22535103 chr8:58192502 C8orf71 -0.6 -13.08 -0.46 8.35e-35 Developmental language disorder (linguistic errors); BRCA cis rs4689388 0.926 rs4458523 chr4:6289986 G/T cg00701064 chr4:6280414 WFS1 -0.66 -18.11 -0.58 1.69e-59 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10870270 1.000 rs3935905 chr10:133758262 A/C cg08754478 chr10:133766260 PPP2R2D -0.68 -14.07 -0.49 2.4e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs6582630 0.531 rs3850000 chr12:38483752 T/C cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs600626 0.636 rs11236516 chr11:75451668 C/T cg24262691 chr11:75473276 NA -0.47 -7.98 -0.3 6.96e-15 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); BRCA cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg21918786 chr6:109611834 NA -0.46 -12.7 -0.45 4.21e-33 Reticulocyte fraction of red cells; BRCA cis rs9393777 0.513 rs13190754 chr6:26587406 G/A cg12292205 chr6:26970375 C6orf41 -0.51 -8.68 -0.32 3.16e-17 Intelligence (multi-trait analysis); BRCA cis rs11229555 1.000 rs12808544 chr11:58373221 C/A cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs7615952 0.576 rs6780025 chr3:125815624 A/C cg07211511 chr3:129823064 LOC729375 -0.62 -10.91 -0.4 1.56e-25 Blood pressure (smoking interaction); BRCA cis rs4481887 0.927 rs4537599 chr1:248508741 G/A cg00666640 chr1:248458726 OR2T12 0.34 8.76 0.33 1.75e-17 Common traits (Other); BRCA cis rs72781680 0.716 rs2712071 chr2:23990419 A/G cg08917208 chr2:24149416 ATAD2B 0.65 10.56 0.39 3.94e-24 Lymphocyte counts; BRCA cis rs2404602 0.684 rs4886816 chr15:76874707 A/C cg23625390 chr15:77176239 SCAPER -0.55 -13.76 -0.48 6.34e-38 Blood metabolite levels; BRCA cis rs7914558 0.966 rs10786724 chr10:104668942 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.36 0.38 2.42e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg06636001 chr8:8085503 FLJ10661 -0.61 -13.52 -0.47 7.84e-37 Mood instability; BRCA cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs4363385 0.747 rs4323653 chr1:152983359 T/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.33 -0.31 5.08e-16 Inflammatory skin disease; BRCA cis rs757110 0.770 rs2051772 chr11:17389850 G/A cg15432903 chr11:17409602 KCNJ11 0.72 15.86 0.53 5.11e-48 Type 2 diabetes; BRCA cis rs11148252 0.740 rs7981050 chr13:52755149 C/T cg00495681 chr13:53174319 NA 0.38 7.9 0.3 1.2e-14 Lewy body disease; BRCA cis rs2629540 0.924 rs1545910 chr10:126428145 G/C cg08799069 chr10:126477246 METTL10 -0.52 -11.24 -0.41 7.09e-27 Cocaine dependence; BRCA cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg24562669 chr7:97807699 LMTK2 0.44 11.82 0.42 2.74e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs2625529 0.878 rs2929511 chr15:72231682 C/T cg16672083 chr15:72433130 SENP8 0.67 16.11 0.54 3.05e-49 Red blood cell count; BRCA cis rs490234 0.841 rs950534 chr9:128225881 C/G cg14078157 chr9:128172775 NA -0.34 -8.16 -0.31 1.78e-15 Mean arterial pressure; BRCA cis rs4948102 0.731 rs6593292 chr7:56043037 G/C cg09872392 chr7:56161020 PHKG1 -0.4 -9.07 -0.34 1.42e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs1552244 1.000 rs112509186 chr3:10156533 A/G cg08888203 chr3:10149979 C3orf24 0.67 14.48 0.5 2.56e-41 Alzheimer's disease; BRCA cis rs757081 0.667 rs3950680 chr11:17138666 G/A cg15432903 chr11:17409602 KCNJ11 -0.46 -8.63 -0.32 4.78e-17 Systolic blood pressure; BRCA cis rs2404602 0.679 rs12899871 chr15:76757347 T/C cg23625390 chr15:77176239 SCAPER 0.39 9.15 0.34 7.8e-19 Blood metabolite levels; BRCA cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg12386194 chr3:101231763 SENP7 -0.46 -9.67 -0.36 9.84e-21 Colorectal cancer; BRCA cis rs4332037 0.539 rs55773130 chr7:2070554 T/C cg23422044 chr7:1970798 MAD1L1 -0.59 -10.86 -0.39 2.59e-25 Bipolar disorder; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg24642844 chr7:1081250 C7orf50 -0.89 -16.21 -0.54 9.83e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg11644478 chr21:40555479 PSMG1 -0.66 -14.2 -0.49 5.77e-40 Cognitive function; BRCA cis rs9914988 0.943 rs4795459 chr17:27113726 G/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7737355 0.898 rs6864413 chr5:130637868 G/T cg06307176 chr5:131281290 NA 0.46 8.87 0.33 7.29e-18 Life satisfaction; BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg04267008 chr7:1944627 MAD1L1 -0.51 -11.71 -0.42 8.08e-29 Bipolar disorder and schizophrenia; BRCA cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg23521905 chr12:129298690 SLC15A4;MGC16384 -0.34 -11.69 -0.42 9.3e-29 Systemic lupus erythematosus; BRCA cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg16414030 chr3:133502952 NA -0.49 -11.52 -0.41 4.73e-28 Iron status biomarkers; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg13880726 chr7:1868755 MAD1L1 0.52 10.27 0.38 5.32e-23 Bipolar disorder and schizophrenia; BRCA cis rs12618769 0.652 rs17034171 chr2:99221095 A/G cg10123293 chr2:99228465 UNC50 0.42 8.49 0.32 1.44e-16 Bipolar disorder; BRCA cis rs17095355 1.000 rs17126902 chr10:111710381 A/G cg00817464 chr10:111662876 XPNPEP1 0.39 9.45 0.35 6.16e-20 Biliary atresia; BRCA cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg27572855 chr1:25598939 RHD 0.52 15.25 0.52 5.13e-45 Erythrocyte sedimentation rate; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg04025307 chr7:1156635 C7orf50 0.59 9.31 0.35 2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7044106 0.791 rs10984997 chr9:123481206 T/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 12.71 0.45 3.8e-33 Hip circumference adjusted for BMI; BRCA cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg24642439 chr20:33292090 TP53INP2 0.42 8.84 0.33 9.58e-18 Height; BRCA cis rs7267979 1.000 rs2482928 chr20:25331530 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.6 -0.32 5.96e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs11722228 0.522 rs7681250 chr4:10133013 G/T cg26043149 chr18:55253948 FECH 1.15 27.71 0.74 1.32e-111 Gout;Urate levels;Serum uric acid levels; BRCA cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.29 0.31 6.45e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg22764044 chr5:178986830 RUFY1 0.5 13.69 0.48 1.38e-37 Lung cancer; BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg00149659 chr3:10157352 C3orf10 0.79 13.76 0.48 6.55e-38 Alzheimer's disease; BRCA trans rs12310956 0.532 rs1525897 chr12:33941033 C/T cg26384229 chr12:38710491 ALG10B 0.67 14.1 0.49 1.68e-39 Morning vs. evening chronotype; BRCA cis rs4363385 0.588 rs6660878 chr1:153027068 A/G cg25856811 chr1:152973957 SPRR3 -0.31 -7.84 -0.3 1.86e-14 Inflammatory skin disease; BRCA cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg14829155 chr15:31115871 NA 0.41 9.97 0.37 7.62e-22 Huntington's disease progression; BRCA cis rs11229555 0.645 rs12274866 chr11:58177129 C/T cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9831754 0.526 rs6548551 chr3:78342292 C/T cg06138941 chr3:78371609 NA 0.41 9.89 0.36 1.44e-21 Calcium levels; BRCA cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg20701182 chr2:24300061 SF3B14 0.69 13.04 0.46 1.21e-34 Lymphocyte counts; BRCA cis rs1829883 0.898 rs2461990 chr5:98793519 G/A cg08333243 chr5:99726346 NA -0.35 -8.01 -0.3 5.27e-15 Hemostatic factors and hematological phenotypes; BRCA trans rs7647973 0.593 rs59684465 chr3:49874246 C/T cg21659725 chr3:3221576 CRBN 0.47 8.67 0.32 3.45e-17 Menarche (age at onset); BRCA cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.57 -0.42 3.14e-28 Intelligence (multi-trait analysis); BRCA cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg11366901 chr6:160182831 ACAT2 0.82 15.22 0.52 7.19e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.15 -0.31 1.96e-15 Total body bone mineral density; BRCA cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg22800045 chr5:56110881 MAP3K1 0.66 12.36 0.44 1.22e-31 Initial pursuit acceleration; BRCA cis rs7178424 1.000 rs8026008 chr15:62377805 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.26 -0.31 8.22e-16 Height; BRCA cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.48e-66 Mean platelet volume; BRCA trans rs7829975 0.564 rs2976855 chr8:8301794 G/A cg21775007 chr8:11205619 TDH 0.41 8.51 0.32 1.23e-16 Mood instability; BRCA cis rs2239547 0.657 rs7620706 chr3:52891756 A/T cg11645453 chr3:52864694 ITIH4 0.48 11.4 0.41 1.52e-27 Schizophrenia; BRCA cis rs11955398 0.604 rs1445852 chr5:59891304 C/T cg02684056 chr5:59996105 DEPDC1B 0.35 8.4 0.32 2.86e-16 Intelligence (multi-trait analysis); BRCA cis rs7769051 1.000 rs9493454 chr6:133144629 G/T cg22852734 chr6:133119734 C6orf192 -0.78 -13.38 -0.47 3.7e-36 Type 2 diabetes nephropathy; BRCA trans rs61931739 0.534 rs1387789 chr12:34056304 C/A cg26384229 chr12:38710491 ALG10B 0.57 12.15 0.43 1.03e-30 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.62 -0.36 1.5e-20 Developmental language disorder (linguistic errors); BRCA cis rs634534 0.591 rs688862 chr11:65733393 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.45 9.86 0.36 1.91e-21 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs870825 0.616 rs35818632 chr4:185649661 G/T cg20176042 chr4:185552304 CASP3 -0.52 -7.92 -0.3 1.03e-14 Blood protein levels; BRCA cis rs1800795 0.553 rs1524099 chr7:22781657 G/A cg05472934 chr7:22766657 IL6 0.35 7.86 0.3 1.67e-14 Cerebrospinal fluid clusterin levels in APOEe4- carriers; BRCA cis rs9790314 0.846 rs9815222 chr3:160994897 C/T cg03342759 chr3:160939853 NMD3 -0.72 -17.95 -0.58 1.25e-58 Morning vs. evening chronotype; BRCA trans rs6598955 0.671 rs12354062 chr1:26608761 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.63 -13.49 -0.47 1.08e-36 Obesity-related traits; BRCA cis rs12497850 0.865 rs7649458 chr3:48920127 C/T cg07636037 chr3:49044803 WDR6 0.96 28.71 0.75 4.39e-117 Parkinson's disease; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg13047869 chr3:10149882 C3orf24 0.6 12.77 0.45 1.93e-33 Alzheimer's disease; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.74 11.42 0.41 1.31e-27 Gut microbiome composition (summer); BRCA cis rs600806 0.778 rs2140923 chr1:110004990 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.45 0.32 2.04e-16 Intelligence (multi-trait analysis); BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.38 -9.16 -0.34 7.18e-19 Bipolar disorder; BRCA cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.63 10.79 0.39 4.65e-25 Lung function (FEV1/FVC); BRCA cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.15e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs703842 0.963 rs923829 chr12:58174306 T/C cg00677455 chr12:58241039 CTDSP2 0.63 15.43 0.52 6.76e-46 Multiple sclerosis; BRCA cis rs11190604 1.000 rs4919472 chr10:102315864 T/A cg07080220 chr10:102295463 HIF1AN 0.64 14.78 0.5 9.46e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs853679 0.513 rs13437444 chr6:28070998 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.33 8.47 0.32 1.63e-16 Depression; BRCA cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg23283495 chr1:209979779 IRF6 0.38 9.15 0.34 7.58e-19 Cleft lip with or without cleft palate; BRCA cis rs12586317 0.883 rs4982254 chr14:35755737 C/T cg16230307 chr14:35515116 FAM177A1 0.46 9.34 0.35 1.6e-19 Psoriasis; BRCA cis rs9309711 0.689 rs4535075 chr2:3481716 T/C cg08493051 chr2:3487164 NA -0.43 -9.25 -0.34 3.35e-19 Neurofibrillary tangles; BRCA cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.55 -14.72 -0.5 1.98e-42 Colorectal cancer; BRCA cis rs9815354 0.761 rs73083326 chr3:41927150 G/T cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7072216 0.763 rs942803 chr10:100168631 G/T cg26618903 chr10:100175079 PYROXD2 -0.32 -9.36 -0.35 1.39e-19 Metabolite levels; BRCA cis rs4820294 0.770 rs7285699 chr22:38066556 A/C cg21798802 chr22:38057573 PDXP 0.31 8.62 0.32 5.36e-17 Fat distribution (HIV); BRCA trans rs10771431 0.810 rs10771418 chr12:9358995 A/G cg27600084 chr12:12264075 NA 0.36 8.39 0.32 3.19e-16 Breast size; BRCA cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg21475434 chr5:93447410 FAM172A 0.69 8.84 0.33 9.14e-18 Diabetic retinopathy; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg22764044 chr5:178986830 RUFY1 0.45 11.38 0.41 1.82e-27 Lung cancer; BRCA cis rs4363385 0.818 rs4845522 chr1:153011099 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs11098499 0.863 rs3733525 chr4:120447048 A/G cg09307838 chr4:120376055 NA 0.69 13.97 0.48 6.93e-39 Corneal astigmatism; BRCA cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.21 0.41 9.51e-27 Monocyte percentage of white cells; BRCA cis rs55882075 0.583 rs9637934 chr5:179114025 G/C cg14593053 chr5:179126677 CANX 0.38 9.51 0.35 3.7e-20 Monocyte percentage of white cells; BRCA cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg02734326 chr4:10020555 SLC2A9 0.39 8.34 0.31 4.56e-16 Bone mineral density; BRCA cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg17971929 chr21:40555470 PSMG1 -0.61 -13.29 -0.47 9.34e-36 Cognitive function; BRCA cis rs17270561 0.666 rs9356988 chr6:25777481 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 9.7 0.36 7.51e-21 Iron status biomarkers; BRCA cis rs34779708 0.966 rs7077242 chr10:35481965 A/C cg03585969 chr10:35415529 CREM -0.49 -10.25 -0.38 6.56e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg04450456 chr4:17643702 FAM184B 0.38 11.32 0.41 3.31e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg22875332 chr1:76189707 ACADM 0.65 14.03 0.49 3.48e-39 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg02659138 chr7:134003124 SLC35B4 -0.36 -10.85 -0.39 2.62e-25 Mean platelet volume; BRCA cis rs7493 0.755 rs13228784 chr7:94960825 A/G cg17330251 chr7:94953956 PON1 -0.4 -8.24 -0.31 9.5e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7572733 0.515 rs6752458 chr2:198835106 G/T cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.49e-21 Dermatomyositis; BRCA trans rs8002861 0.870 rs9525855 chr13:44431660 A/G cg17145862 chr1:211918768 LPGAT1 0.63 16.2 0.54 1.07e-49 Leprosy; BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.58 0.65 5.52e-78 Gut microbiome composition (summer); BRCA trans rs6479891 1.000 rs10740117 chr10:65098277 G/A cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs17685 0.753 rs6464999 chr7:75787315 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7254114 0.578 rs4804574 chr19:11317482 G/A cg06870470 chr19:11315767 DOCK6 0.4 9.44 0.35 6.9e-20 Immature fraction of reticulocytes; BRCA cis rs9790314 0.613 rs6799160 chr3:160634889 A/G cg03342759 chr3:160939853 NMD3 0.43 8.29 0.31 6.76e-16 Morning vs. evening chronotype; BRCA cis rs11945232 1.000 rs28609242 chr4:88342497 T/C cg23841344 chr4:88312519 HSD17B11 -0.48 -9.49 -0.35 4.54e-20 Intelligence (multi-trait analysis); BRCA cis rs796364 0.951 rs35618222 chr2:201065777 C/G cg23649088 chr2:200775458 C2orf69 0.62 10.69 0.39 1.16e-24 Schizophrenia; BRCA cis rs5167 0.504 rs7259679 chr19:45457306 C/T cg13119609 chr19:45449297 APOC2 0.46 12.83 0.45 1.04e-33 Blood protein levels; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07343612 chr16:622815 PIGQ -0.68 -22.3 -0.66 6.78e-82 Height; BRCA cis rs7829975 0.688 rs7826654 chr8:8379106 C/T cg15556689 chr8:8085844 FLJ10661 0.49 13.87 0.48 2.09e-38 Mood instability; BRCA cis rs72781680 0.821 rs111571980 chr2:24201695 C/G cg08917208 chr2:24149416 ATAD2B 0.61 10.39 0.38 1.73e-23 Lymphocyte counts; BRCA cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs4664304 0.620 rs11675085 chr2:160713352 C/G cg18514922 chr2:160761262 LY75 0.34 7.97 0.3 7.22e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs28735056 0.935 rs537962 chr18:77592660 C/G cg20368463 chr18:77673604 PQLC1 0.35 8.41 0.32 2.75e-16 Schizophrenia; BRCA cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.29 0.38 4.48e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg00684032 chr4:1343700 KIAA1530 -0.34 -8.86 -0.33 7.7e-18 Obesity-related traits; BRCA cis rs9341808 0.754 rs3805885 chr6:80996751 C/G cg08355045 chr6:80787529 NA -0.35 -8.96 -0.33 3.65e-18 Sitting height ratio; BRCA cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg00701064 chr4:6280414 WFS1 0.71 19.5 0.61 7.91e-67 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs4824093 0.610 rs4141437 chr22:50243719 C/G cg09872104 chr7:134855509 C7orf49 0.77 9.66 0.36 1.08e-20 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.775 rs72650869 chr8:58157923 T/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg09021430 chr5:549028 NA -0.67 -15.05 -0.51 4.83e-44 Lung disease severity in cystic fibrosis; BRCA cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg03161606 chr19:29218774 NA 0.46 8.11 0.31 2.58e-15 Methadone dose in opioid dependence; BRCA cis rs9560113 0.959 rs9560108 chr13:112180303 A/C cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs13136331 0.680 rs4440183 chr4:88653805 C/T cg22416721 chr4:88570574 DMP1 -0.57 -13.48 -0.47 1.2e-36 Sitting height ratio; BRCA cis rs6835098 0.962 rs4377567 chr4:174083590 C/G cg08422745 chr4:174089978 GALNT7 0.79 18.33 0.59 1.24e-60 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg27347728 chr4:17578864 LAP3 0.43 8.25 0.31 9.07e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4722404 0.592 rs7791687 chr7:3119643 G/A cg19214707 chr7:3157722 NA -0.37 -8.04 -0.3 4.38e-15 Atopic dermatitis; BRCA trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg08313168 chr12:7315531 NA 0.48 7.94 0.3 8.93e-15 Lung disease severity in cystic fibrosis; BRCA cis rs507080 0.885 rs533144 chr11:118559247 C/A cg09144398 chr11:118550485 TREH -0.36 -8.78 -0.33 1.47e-17 Serum metabolite levels; BRCA cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg15997130 chr1:24165203 NA -0.45 -10.18 -0.37 1.16e-22 Immature fraction of reticulocytes; BRCA cis rs7633857 0.512 rs1868109 chr3:160682500 G/A cg03342759 chr3:160939853 NMD3 -0.55 -11.63 -0.42 1.77e-28 Educational attainment (years of education); BRCA trans rs7980799 0.935 rs1905408 chr12:33516963 G/A cg26384229 chr12:38710491 ALG10B -0.4 -8.5 -0.32 1.35e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg18357526 chr6:26021779 HIST1H4A 0.46 8.51 0.32 1.24e-16 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs34628820 chr4:99004764 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs16910800 0.689 rs7101825 chr11:23164951 C/G cg20040320 chr11:23191996 NA 0.48 8.34 0.31 4.46e-16 Cancer; BRCA cis rs4660306 1.000 rs6667191 chr1:45982844 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.93 -0.3 9.68e-15 Homocysteine levels; BRCA cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg13010199 chr12:38710504 ALG10B 0.52 10.87 0.4 2.24e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs2336384 0.929 rs2236056 chr1:12056440 C/T cg13216073 chr1:12042593 MFN2 0.49 10.53 0.38 4.98e-24 Platelet count; BRCA trans rs61931739 1.000 rs12311881 chr12:34036100 A/G cg26384229 chr12:38710491 ALG10B -0.42 -9.4 -0.35 9.2e-20 Morning vs. evening chronotype; BRCA trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg03929089 chr4:120376271 NA 0.61 10.56 0.39 3.97e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg26597838 chr10:835615 NA 1.3 21.86 0.65 1.6e-79 Eosinophil percentage of granulocytes; BRCA cis rs763121 0.853 rs9607566 chr22:39075434 C/G cg06544989 chr22:39130855 UNC84B 0.35 8.37 0.31 3.56e-16 Menopause (age at onset); BRCA cis rs295140 0.585 rs4233996 chr2:201131228 A/T cg23649088 chr2:200775458 C2orf69 -0.38 -8.14 -0.31 2.07e-15 QT interval; BRCA trans rs12310956 0.510 rs1565026 chr12:33887499 A/G cg26384229 chr12:38710491 ALG10B 0.4 9.36 0.35 1.37e-19 Morning vs. evening chronotype; BRCA cis rs7103648 1.000 rs10838709 chr11:47447346 C/T cg03711944 chr11:47377212 SPI1 -0.41 -10.91 -0.4 1.61e-25 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs875971 0.545 rs6970498 chr7:65740895 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.57 10.42 0.38 1.35e-23 Aortic root size; BRCA cis rs2120243 0.845 rs2316710 chr3:157150180 G/T cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.51 0.35 3.96e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs2762353 0.808 rs1185568 chr6:25834428 T/A cg03517284 chr6:25882590 NA -0.51 -11.52 -0.41 5.1e-28 Blood metabolite levels; BRCA cis rs9325144 0.647 rs35254764 chr12:39102928 T/C cg26384229 chr12:38710491 ALG10B -0.48 -11.23 -0.41 7.66e-27 Morning vs. evening chronotype; BRCA cis rs7927771 0.965 rs35184771 chr11:47475189 G/T cg18512352 chr11:47633146 NA -0.37 -8.99 -0.33 2.85e-18 Subjective well-being; BRCA cis rs12950390 0.893 rs4239166 chr17:45847329 A/G cg24803719 chr17:45855879 NA -0.32 -8.51 -0.32 1.26e-16 IgG glycosylation; BRCA cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg06784218 chr1:46089804 CCDC17 -0.43 -10.13 -0.37 1.82e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg08493051 chr2:3487164 NA -0.43 -9.15 -0.34 7.42e-19 Neurofibrillary tangles; BRCA cis rs9469578 0.792 rs79297236 chr6:33713930 T/C cg18708504 chr6:33715942 IP6K3 0.7 10.18 0.37 1.12e-22 Phosphorus levels; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg02353165 chr6:42928485 GNMT 0.78 18.86 0.6 2.17e-63 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1784581 0.802 rs2156747 chr6:162430000 C/G cg17173639 chr6:162384350 PARK2 -0.37 -8.92 -0.33 4.71e-18 Itch intensity from mosquito bite; BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg10729496 chr3:10149963 C3orf24 0.48 9.07 0.34 1.5e-18 Alzheimer's disease; BRCA cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg24069376 chr3:38537580 EXOG 0.34 9.36 0.35 1.35e-19 Electrocardiographic conduction measures; BRCA cis rs6831352 0.918 rs13140423 chr4:100050400 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs61935443 0.666 rs73218073 chr12:95314346 A/G cg21533806 chr12:95267307 NA 0.45 8.01 0.3 5.54e-15 Schizophrenia; BRCA cis rs13108904 0.557 rs1680030 chr4:1245500 A/T cg16405210 chr4:1374714 KIAA1530 0.65 13.59 0.47 3.78e-37 Obesity-related traits; BRCA cis rs4363385 0.818 rs57311099 chr1:153005597 A/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs10751667 0.666 rs7396059 chr11:970490 C/A ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA trans rs61931739 0.853 rs7137146 chr12:34102394 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.25 -0.38 6.04e-23 Morning vs. evening chronotype; BRCA cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg11890956 chr21:40555474 PSMG1 1.03 27.92 0.74 9.19e-113 Cognitive function; BRCA cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg01877450 chr7:97915802 BRI3 -0.36 -8.2 -0.31 1.28e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg20203395 chr5:56204925 C5orf35 -0.52 -10.53 -0.38 4.88e-24 Type 2 diabetes; BRCA cis rs796364 1.000 rs281763 chr2:200794870 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.2 0.46 2.26e-35 Schizophrenia; BRCA cis rs10779751 0.770 rs2275527 chr1:11190646 A/G cg08854313 chr1:11322531 MTOR 0.7 13.97 0.48 7.06e-39 Body mass index; BRCA cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg25427524 chr10:38739819 LOC399744 -0.71 -17.44 -0.57 5.3e-56 Extrinsic epigenetic age acceleration; BRCA cis rs5771069 0.931 rs137864 chr22:50446988 C/T cg03721641 chr22:50451245 IL17REL 0.32 9.91 0.36 1.24e-21 Ulcerative colitis; BRCA cis rs6088590 0.813 rs1884668 chr20:33285514 A/G cg08999081 chr20:33150536 PIGU 0.44 11.76 0.42 4.8e-29 Coronary artery disease; BRCA trans rs9929218 1.000 rs7186084 chr16:68816260 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.61 12.2 0.43 6.3e-31 Colorectal cancer; BRCA trans rs1997103 1.000 rs9642580 chr7:55400359 G/A cg20935933 chr6:143382018 AIG1 0.6 11.48 0.41 7.49e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4919087 1.000 rs7076523 chr10:99089296 T/C cg25902810 chr10:99078978 FRAT1 -0.45 -9.49 -0.35 4.54e-20 Monocyte count; BRCA cis rs1577917 0.883 rs6454505 chr6:86592362 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.32 -8.34 -0.31 4.55e-16 Response to antipsychotic treatment; BRCA cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg10523679 chr1:76189770 ACADM 0.69 11.75 0.42 5.22e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.651 rs1292338 chr6:145967471 A/C cg23711669 chr6:146136114 FBXO30 -0.71 -17.19 -0.56 9.59e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.866 rs7677068 chr4:120291704 C/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs7666738 0.715 rs3857216 chr4:99032129 G/T cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg03146154 chr1:46216737 IPP 0.45 9.92 0.37 1.1e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2108225 1.000 rs989960 chr7:107445727 C/T cg18560240 chr7:107437656 SLC26A3 -0.53 -10.66 -0.39 1.57e-24 Ulcerative colitis; BRCA cis rs35110281 0.641 rs4819283 chr21:45083011 T/A cg21573476 chr21:45109991 RRP1B -0.49 -12.84 -0.45 9.49e-34 Mean corpuscular volume; BRCA cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg27478167 chr7:817139 HEATR2 -0.42 -8.72 -0.33 2.49e-17 Cerebrospinal P-tau181p levels; BRCA trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg11707556 chr5:10655725 ANKRD33B -0.48 -11.91 -0.43 1.1e-29 Coronary artery disease; BRCA cis rs7945718 0.967 rs7927470 chr11:12748899 A/T cg25843174 chr11:12811716 TEAD1 0.23 8.47 0.32 1.72e-16 Educational attainment (years of education); BRCA cis rs17401966 0.894 rs11587309 chr1:10446596 G/T cg19773385 chr1:10388646 KIF1B -0.38 -7.99 -0.3 6.17e-15 Hepatocellular carcinoma; BRCA cis rs6121246 0.559 rs6121038 chr20:30254773 T/G cg21427119 chr20:30132790 HM13 -0.36 -8.27 -0.31 7.77e-16 Mean corpuscular hemoglobin; BRCA cis rs701145 0.643 rs7647694 chr3:153851535 C/G cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs9399137 0.507 rs13196486 chr6:135283874 C/G cg22676075 chr6:135203613 NA 0.44 8.7 0.33 2.91e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4642101 0.737 rs6767504 chr3:12826667 C/T cg24848339 chr3:12840334 CAND2 0.43 11.43 0.41 1.19e-27 QRS complex (12-leadsum); BRCA cis rs7100689 0.646 rs2039757 chr10:82078868 C/A cg00277334 chr10:82204260 NA -0.43 -8.47 -0.32 1.74e-16 Post bronchodilator FEV1; BRCA cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg23788917 chr6:8435910 SLC35B3 0.47 10.13 0.37 1.84e-22 Motion sickness; BRCA cis rs4363385 0.747 rs3806219 chr1:152972522 C/T cg21543102 chr1:152974771 SPRR3 0.29 8.27 0.31 7.84e-16 Inflammatory skin disease; BRCA cis rs9487051 0.737 rs1260593 chr6:109521400 C/T cg01475377 chr6:109611718 NA -0.45 -11.4 -0.41 1.58e-27 Reticulocyte fraction of red cells; BRCA cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.7 -0.33 2.88e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg12549451 chr6:135224345 NA -0.36 -8.32 -0.31 5.18e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg25036284 chr2:26402008 FAM59B 0.9 14.79 0.5 9.2e-43 Gut microbiome composition (summer); BRCA cis rs11123610 0.520 rs66646194 chr2:3720420 G/A cg19052272 chr2:3704530 ALLC -0.45 -10.16 -0.37 1.44e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg03354898 chr7:1950403 MAD1L1 -0.4 -8.32 -0.31 5.49e-16 Bipolar disorder and schizophrenia; BRCA cis rs67460515 0.892 rs7610985 chr3:161062848 G/A cg03342759 chr3:160939853 NMD3 -0.81 -17.91 -0.58 2.06e-58 Parkinson's disease; BRCA cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7586879 0.639 rs6713978 chr2:25120851 T/C cg01884057 chr2:25150051 NA 0.34 9.04 0.34 1.88e-18 Body mass index; BRCA trans rs8073060 0.614 rs225279 chr17:33974214 A/G cg19694781 chr19:47549865 TMEM160 -1.05 -20.96 -0.64 1.16e-74 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs10463316 0.817 rs13355052 chr5:150802003 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.62 -0.32 5.19e-17 Metabolite levels (Pyroglutamine); BRCA cis rs561341 1.000 rs473356 chr17:30321762 G/C cg00745463 chr17:30367425 LRRC37B -0.54 -8.89 -0.33 6.17e-18 Hip circumference adjusted for BMI; BRCA cis rs10751667 0.580 rs7395515 chr11:1005160 C/T ch.11.42038R chr11:967971 AP2A2 0.47 14.38 0.49 8.06e-41 Alzheimer's disease (late onset); BRCA cis rs28374715 0.578 rs8036026 chr15:41630499 C/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.8 -0.71 4.21e-101 Ulcerative colitis; BRCA cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg12011299 chr4:100065546 ADH4 0.41 10.68 0.39 1.35e-24 Alcohol dependence; BRCA cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg06145435 chr7:1022769 CYP2W1 0.49 9.08 0.34 1.39e-18 Bronchopulmonary dysplasia; BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg00814883 chr7:100076585 TSC22D4 -0.54 -11.63 -0.42 1.77e-28 Platelet count; BRCA cis rs9733 0.596 rs11582840 chr1:150688487 A/G cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs7766436 0.885 rs12662891 chr6:22575096 C/T cg13666174 chr6:22585274 NA -0.48 -11.13 -0.4 2.06e-26 Coronary artery disease; BRCA cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg26395211 chr5:140044315 WDR55 0.35 7.97 0.3 7.14e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg09065629 chr16:1709722 CRAMP1L 0.36 8.49 0.32 1.45e-16 Coronary artery disease; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.56 -0.42 3.28e-28 Lymphocyte counts; BRCA cis rs3008870 0.755 rs2755251 chr1:67496425 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.6 13.12 0.46 5.72e-35 Lymphocyte percentage of white cells; BRCA cis rs35123781 1.000 rs599946 chr5:139057461 A/G cg05227215 chr5:139057496 CXXC5 0.35 8.43 0.32 2.31e-16 Schizophrenia; BRCA cis rs7264396 0.635 rs6060673 chr20:34482396 C/T cg23207816 chr20:34252616 CPNE1;RBM12 -0.36 -7.81 -0.3 2.33e-14 Total cholesterol levels; BRCA cis rs11051970 0.636 rs2733704 chr12:32567858 C/T cg02745156 chr12:32552066 NA 0.25 8.23 0.31 1.07e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs4671400 0.543 rs10178135 chr2:61485267 T/C cg15711740 chr2:61764176 XPO1 0.42 9.05 0.34 1.67e-18 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs4561483 0.831 rs2075158 chr16:11945231 T/C cg08843971 chr16:11963173 GSPT1 0.43 8.84 0.33 8.89e-18 Testicular germ cell tumor; BRCA trans rs3808502 0.527 rs4410870 chr8:11156120 C/G cg15556689 chr8:8085844 FLJ10661 -0.33 -7.86 -0.3 1.66e-14 Neuroticism; BRCA cis rs1997103 1.000 rs10228182 chr7:55406695 A/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2463822 0.925 rs6863 chr11:62160725 G/T cg06239285 chr11:62104954 ASRGL1 -0.63 -8.79 -0.33 1.38e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs2235642 0.859 rs12599207 chr16:1606445 A/G cg26528668 chr16:1614120 IFT140 0.39 8.73 0.33 2.26e-17 Coronary artery disease; BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg08219700 chr8:58056026 NA 0.57 9.48 0.35 4.72e-20 Developmental language disorder (linguistic errors); BRCA cis rs67460515 0.528 rs11915989 chr3:160902259 A/G cg03342759 chr3:160939853 NMD3 -0.73 -15.48 -0.52 3.69e-46 Parkinson's disease; BRCA cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg19539972 chr4:7069911 GRPEL1 0.69 16.91 0.56 2.78e-53 Monocyte percentage of white cells; BRCA cis rs9533799 1.000 rs11620543 chr13:44798371 G/A cg19190762 chr13:44806055 NA 0.4 8.66 0.32 3.7e-17 Amyotrophic lateral sclerosis; BRCA cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.655 rs9381032 chr6:41044986 A/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.98 -0.33 3.08e-18 Alzheimer's disease (late onset); BRCA cis rs4631830 0.720 rs11599333 chr10:51499655 A/C cg16070123 chr10:51489643 NA 0.35 7.86 0.3 1.69e-14 Prostate-specific antigen levels; BRCA cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg25767906 chr1:53392781 SCP2 -0.39 -8.04 -0.3 4.25e-15 Monocyte count; BRCA cis rs887829 0.569 rs4663965 chr2:234650604 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.6 -0.32 6.05e-17 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs3099143 1.000 rs4541044 chr15:77173193 C/T cg21673338 chr15:77095150 SCAPER 0.52 9.44 0.35 6.69e-20 Recalcitrant atopic dermatitis; BRCA cis rs11146838 1 rs11146838 chr10:39149977 A/T cg18963800 chr10:38644991 HSD17B7P2 -0.44 -8.78 -0.33 1.46e-17 Breast cancer; BRCA cis rs3820928 1.000 rs6752707 chr2:227766822 C/G cg11843606 chr2:227700838 RHBDD1 -0.39 -8.63 -0.32 4.82e-17 Pulmonary function; BRCA cis rs10927875 1.000 rs10927875 chr1:16299312 A/G cg21385522 chr1:16154831 NA 0.6 11.54 0.42 4.01e-28 Dilated cardiomyopathy; BRCA cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg22875332 chr1:76189707 ACADM -0.48 -9.13 -0.34 9.22e-19 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg27446573 chr6:127587934 RNF146 0.9 21.49 0.65 1.64e-77 Breast cancer; BRCA cis rs6840258 0.660 rs17012200 chr4:87884646 C/G cg08197287 chr4:87952173 AFF1 0.47 8.61 0.32 5.6e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs11229555 1.000 rs2276153 chr11:58407740 C/G cg15696309 chr11:58395628 NA -0.52 -11.43 -0.41 1.2e-27 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6089584 1.000 rs6089580 chr20:60558976 G/A cg06108461 chr20:60628389 TAF4 -0.79 -16.99 -0.56 1.11e-53 Body mass index; BRCA cis rs941408 1.000 rs1640272 chr19:2800192 A/T cg06609049 chr19:2785107 THOP1 0.57 11.89 0.43 1.31e-29 Total cholesterol levels; BRCA cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg02544614 chr20:61657117 NA 0.28 7.92 0.3 1.03e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.580 rs2225765 chr6:8481785 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.22e-41 Motion sickness; BRCA cis rs6952808 0.609 rs4721190 chr7:1954732 A/G cg14004847 chr7:1930337 MAD1L1 0.45 9.13 0.34 8.94e-19 Bipolar disorder and schizophrenia; BRCA cis rs6964587 1.000 rs2188155 chr7:91599825 A/C cg17063962 chr7:91808500 NA 0.53 12.53 0.44 2.32e-32 Breast cancer; BRCA cis rs10267417 0.603 rs4721836 chr7:19910497 A/G cg05791153 chr7:19748676 TWISTNB 0.46 9.01 0.34 2.29e-18 Night sleep phenotypes; BRCA cis rs17270561 1.000 rs12200962 chr6:25828986 T/C cg16482183 chr6:26056742 HIST1H1C 0.74 12.96 0.46 2.9e-34 Iron status biomarkers; BRCA cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg12011299 chr4:100065546 ADH4 0.49 10.97 0.4 8.73e-26 Smoking initiation; BRCA cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg01028140 chr2:1542097 TPO -0.61 -11.67 -0.42 1.16e-28 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg07148914 chr20:33460835 GGT7 -0.37 -7.96 -0.3 8.05e-15 Glomerular filtration rate (creatinine); BRCA trans rs6952808 0.692 rs59619245 chr7:2068630 C/T cg04565464 chr8:145669602 NFKBIL2 0.41 9.35 0.35 1.51e-19 Bipolar disorder and schizophrenia; BRCA cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11644478 chr21:40555479 PSMG1 0.73 14.48 0.5 2.74e-41 Cognitive function; BRCA cis rs9287719 0.967 rs7600587 chr2:10739851 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg23625390 chr15:77176239 SCAPER 0.35 7.97 0.3 7.23e-15 Blood metabolite levels; BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.53 -9.22 -0.34 4.28e-19 Renal function-related traits (BUN); BRCA cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg25817165 chr18:72167213 CNDP2 -0.77 -19.62 -0.61 1.84e-67 Refractive error; BRCA cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg04025307 chr7:1156635 C7orf50 0.37 8.32 0.31 5.45e-16 Longevity;Endometriosis; BRCA cis rs11190604 1.000 rs7100386 chr10:102301417 C/T cg07080220 chr10:102295463 HIF1AN 0.65 15.51 0.52 2.69e-46 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2075371 0.966 rs1646646 chr7:133996905 G/T cg20476274 chr7:133979776 SLC35B4 0.7 21.33 0.64 1.25e-76 Mean platelet volume; BRCA cis rs875971 0.862 rs11773628 chr7:65982631 G/T cg18876405 chr7:65276391 NA -0.51 -11.47 -0.41 7.75e-28 Aortic root size; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg08132940 chr7:1081526 C7orf50 -0.6 -8.74 -0.33 2.03e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.13 0.37 1.75e-22 Mean platelet volume; BRCA trans rs9325144 0.581 rs2730929 chr12:38942739 T/C cg23762105 chr12:34175262 ALG10 0.35 7.88 0.3 1.43e-14 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg08219700 chr8:58056026 NA 0.46 8.19 0.31 1.44e-15 Developmental language disorder (linguistic errors); BRCA cis rs7833790 0.654 rs7835342 chr8:82698092 A/G cg17211192 chr8:82754475 SNX16 -0.5 -10.75 -0.39 7.13e-25 Diastolic blood pressure; BRCA cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.79 -15.83 -0.53 7.67e-48 Chronic sinus infection; BRCA cis rs9291683 0.645 rs11557743 chr4:10118377 C/G cg11266682 chr4:10021025 SLC2A9 -0.37 -9.48 -0.35 4.7e-20 Bone mineral density; BRCA cis rs2243480 0.908 rs313822 chr7:65573939 G/A cg18252515 chr7:66147081 NA -1.06 -15.28 -0.52 3.86e-45 Diabetic kidney disease; BRCA cis rs897080 0.515 rs1067404 chr2:44675823 G/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.53 -9.27 -0.34 2.9e-19 Height; BRCA trans rs28735056 0.572 rs4799100 chr18:77640207 A/G cg05926928 chr17:57297772 GDPD1 -0.51 -10.22 -0.37 8.25e-23 Schizophrenia; BRCA cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.22 -0.34 4.27e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 0.806 rs1880374 chr3:134322113 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4478858 0.735 rs4949393 chr1:31851875 G/A cg00250761 chr1:31883323 NA -0.32 -8.44 -0.32 2.18e-16 Alcohol dependence; BRCA cis rs4363385 0.747 rs946097 chr1:152974732 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.24 -0.31 1.01e-15 Inflammatory skin disease; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.56 -0.39 3.98e-24 Lymphocyte counts; BRCA cis rs921968 0.643 rs600057 chr2:219456737 A/G cg02176678 chr2:219576539 TTLL4 0.4 10.88 0.4 2.09e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg07952391 chr2:88470173 THNSL2 0.64 8.61 0.32 5.56e-17 Plasma clusterin levels; BRCA cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg17173187 chr15:85201210 NMB 0.43 9.17 0.34 6.42e-19 Schizophrenia; BRCA cis rs4363385 0.747 rs4240866 chr1:152954875 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.29 -0.34 2.43e-19 Inflammatory skin disease; BRCA cis rs807669 0.524 rs11089258 chr22:19162276 C/T cg02655711 chr22:19163373 SLC25A1 0.5 11.94 0.43 8.72e-30 Metabolite levels; BRCA cis rs4499344 0.604 rs259245 chr19:33145106 A/G cg22980127 chr19:33182716 NUDT19 -0.4 -7.91 -0.3 1.17e-14 Mean platelet volume; BRCA cis rs17253792 0.822 rs78323463 chr14:56045451 T/G cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.29e-20 Putamen volume; BRCA cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg12935359 chr14:103987150 CKB -0.58 -13.9 -0.48 1.46e-38 Body mass index; BRCA cis rs7178424 0.811 rs12899801 chr15:62246864 G/A cg00456672 chr15:62358751 C2CD4A 0.35 8.58 0.32 7.08e-17 Height; BRCA cis rs950776 0.684 rs61012457 chr15:78865694 C/G cg06917634 chr15:78832804 PSMA4 0.67 13.89 0.48 1.53e-38 Sudden cardiac arrest; BRCA cis rs9039 1.000 rs9039 chr16:9205363 A/G cg08831531 chr16:9218945 NA -0.62 -13.57 -0.47 4.61e-37 Menopause (age at onset); BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg14004847 chr7:1930337 MAD1L1 -0.39 -8.0 -0.3 6.01e-15 Bipolar disorder and schizophrenia; BRCA cis rs6912958 0.781 rs3918467 chr6:88180388 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.29 -8.27 -0.31 8e-16 Monocyte percentage of white cells; BRCA cis rs4363385 0.818 rs4845335 chr1:152993955 G/A cg24667326 chr1:152973720 SPRR3 -0.31 -8.37 -0.31 3.71e-16 Inflammatory skin disease; BRCA cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.16 0.31 1.81e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs1994135 0.647 rs11052745 chr12:33695999 G/T cg26384229 chr12:38710491 ALG10B 0.39 8.56 0.32 8.7e-17 Resting heart rate; BRCA trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg20587970 chr11:113659929 NA 0.82 13.88 0.48 1.85e-38 Hip circumference adjusted for BMI; BRCA cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg08048268 chr3:133502702 NA -0.43 -11.15 -0.4 1.72e-26 Iron status biomarkers; BRCA cis rs11039216 1 rs11039216 chr11:47406592 C/T cg03711944 chr11:47377212 SPI1 -0.34 -9.07 -0.34 1.42e-18 Neuroticism; BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg08470875 chr2:26401718 FAM59B 0.76 11.41 0.41 1.47e-27 Gut microbiome composition (summer); BRCA cis rs9815354 0.812 rs73081392 chr3:41923009 G/A cg03022575 chr3:42003672 ULK4 0.71 9.74 0.36 5.4e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs739401 0.611 rs494427 chr11:3048140 A/G cg05729581 chr11:3078854 CARS -0.35 -8.63 -0.32 5.02e-17 Longevity; BRCA cis rs11229555 0.645 rs12289985 chr11:58185436 C/G cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg18876405 chr7:65276391 NA -0.51 -11.75 -0.42 5.48e-29 Aortic root size; BRCA cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg00074818 chr8:8560427 CLDN23 0.38 8.26 0.31 8.19e-16 Obesity-related traits; BRCA cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs4965272 0.830 rs11637820 chr15:100560239 C/T cg27344315 chr15:100560801 ADAMTS17 -0.41 -8.99 -0.33 2.83e-18 Gastroesophageal reflux disease; BRCA cis rs2439831 0.850 rs28578398 chr15:44075046 T/C cg10011062 chr15:43941034 CATSPER2 -0.53 -7.81 -0.3 2.27e-14 Lung cancer in ever smokers; BRCA cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.67 -0.45 5.66e-33 Bipolar disorder; BRCA cis rs700651 0.821 rs4850812 chr2:198743655 G/T cg00792783 chr2:198669748 PLCL1 -0.47 -10.14 -0.37 1.7e-22 Intracranial aneurysm; BRCA cis rs7267979 1.000 rs884613 chr20:25288505 C/T cg08601574 chr20:25228251 PYGB -0.39 -8.95 -0.33 3.74e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2859741 0.587 rs580029 chr1:37471609 C/A cg09363841 chr1:37513479 NA -0.46 -9.61 -0.36 1.67e-20 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg25427524 chr10:38739819 LOC399744 -0.69 -16.69 -0.55 3.49e-52 Extrinsic epigenetic age acceleration; BRCA trans rs7980799 0.682 rs10844611 chr12:33603544 T/C cg26384229 chr12:38710491 ALG10B -0.49 -10.58 -0.39 3.34e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg05283184 chr6:79620031 NA -0.35 -8.21 -0.31 1.27e-15 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.931 rs7430198 chr3:48988760 T/C cg07636037 chr3:49044803 WDR6 0.97 28.46 0.75 1.02e-115 Parkinson's disease; BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.69 0.42 9.4e-29 Tonsillectomy; BRCA cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg17689763 chr4:710664 PCGF3 -0.59 -13.36 -0.47 4.53e-36 White blood cell count; BRCA cis rs9323205 0.577 rs9672038 chr14:51724856 A/G cg23942311 chr14:51606299 NA -0.38 -9.41 -0.35 8.8e-20 Cancer; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg01305625 chr5:131593812 PDLIM4 -0.36 -8.72 -0.33 2.36e-17 Acylcarnitine levels; BRCA cis rs7100689 0.542 rs7096715 chr10:82195949 T/C cg01528321 chr10:82214614 TSPAN14 0.73 16.46 0.55 5.31e-51 Post bronchodilator FEV1; BRCA cis rs4665809 0.816 rs2384359 chr2:26371364 T/C cg26314531 chr2:26401878 FAM59B -0.83 -13.24 -0.46 1.6e-35 Gut microbiome composition (summer); BRCA cis rs17270561 0.553 rs9379784 chr6:25725506 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.79 0.33 1.43e-17 Iron status biomarkers; BRCA cis rs1707322 0.964 rs10437063 chr1:46273666 G/A cg03146154 chr1:46216737 IPP 0.46 10.03 0.37 4.21e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2404602 1.000 rs12148786 chr15:76800362 A/G cg23625390 chr15:77176239 SCAPER 0.42 10.33 0.38 3.04e-23 Blood metabolite levels; BRCA cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs4319547 0.656 rs7294559 chr12:122837564 C/A cg05707623 chr12:122985044 ZCCHC8 -0.49 -9.46 -0.35 5.83e-20 Body mass index; BRCA cis rs9462027 0.583 rs11755420 chr6:34760956 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA cis rs867371 0.929 rs1045508 chr15:82449906 A/C cg00614314 chr15:82944287 LOC80154 -0.43 -9.26 -0.34 3.04e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.67 0.57 3.29e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs8180040 0.966 rs17476234 chr3:47326298 G/A cg16586182 chr3:47516702 SCAP 0.61 14.11 0.49 1.55e-39 Colorectal cancer; BRCA cis rs10496034 1.000 rs17046514 chr2:55185862 C/T cg16098955 chr2:55172992 EML6 0.51 9.07 0.34 1.5e-18 Refractive astigmatism; BRCA cis rs9486719 0.843 rs2499793 chr6:96846402 A/C cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs4363385 0.747 rs4240866 chr1:152954875 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.79 -0.33 1.42e-17 Inflammatory skin disease; BRCA cis rs870825 0.655 rs2310104 chr4:185619967 A/G cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs3091242 0.933 rs926438 chr1:25753638 C/T cg02931644 chr1:25747376 RHCE 0.41 11.33 0.41 2.97e-27 Erythrocyte sedimentation rate; BRCA cis rs265548 0.646 rs36689 chr19:17910639 A/G cg21960279 chr19:17905606 B3GNT3 0.49 11.23 0.41 8.09e-27 Tumor biomarkers; BRCA cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg23887609 chr12:130822674 PIWIL1 0.42 9.22 0.34 4.35e-19 Menopause (age at onset); BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg04025307 chr7:1156635 C7orf50 0.61 15.39 0.52 1.12e-45 Longevity;Endometriosis; BRCA cis rs6976053 0.541 rs314359 chr7:100411278 T/C cg03098644 chr7:100410630 EPHB4 -0.44 -8.9 -0.33 5.89e-18 Plasminogen activator inhibitor type 1 levels (PAI-1); BRCA cis rs698833 0.892 rs1067322 chr2:44630107 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.68 0.39 1.32e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs9329221 1.000 rs9329221 chr8:10240202 G/T cg06636001 chr8:8085503 FLJ10661 0.48 10.44 0.38 1.2e-23 Neuroticism; BRCA cis rs6120849 0.754 rs6088691 chr20:33633758 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs11711311 0.712 rs3773684 chr3:113334488 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.4 8.55 0.32 9.22e-17 IgG glycosylation; BRCA cis rs2842992 0.789 rs2295901 chr6:160201295 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.61 13.05 0.46 1.17e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs4853036 0.672 rs1840340 chr2:70025457 C/T cg02498382 chr2:70120550 SNRNP27 0.41 7.89 0.3 1.34e-14 Colorectal or endometrial cancer; BRCA cis rs1267303 0.600 rs57100184 chr1:47004710 A/C cg25110126 chr1:46999211 NA 0.71 13.09 0.46 7.48e-35 Monobrow; BRCA cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg02659138 chr7:134003124 SLC35B4 0.35 10.06 0.37 3.25e-22 Mean platelet volume; BRCA cis rs3749237 0.964 rs1799843 chr3:49849723 G/A cg03060546 chr3:49711283 APEH 0.47 10.13 0.37 1.84e-22 Resting heart rate; BRCA trans rs9291683 0.561 rs3733584 chr4:10036506 T/C cg26043149 chr18:55253948 FECH 0.42 8.99 0.34 2.84e-18 Bone mineral density; BRCA cis rs13108904 0.901 rs12509700 chr4:1296321 A/G cg01939980 chr4:1354348 KIAA1530 0.3 8.02 0.3 5.12e-15 Obesity-related traits; BRCA cis rs7584330 0.826 rs72620824 chr2:238381083 G/A cg14458575 chr2:238380390 NA 0.76 16.87 0.56 4.4e-53 Prostate cancer; BRCA cis rs6062302 0.522 rs11696202 chr20:62246292 G/C cg03425785 chr20:62221387 GMEB2 0.51 8.27 0.31 7.88e-16 Glioblastoma; BRCA cis rs11711311 1.000 rs921741 chr3:113444051 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.31 7.96 0.3 7.79e-15 IgG glycosylation; BRCA cis rs3824867 0.879 rs10769267 chr11:47460098 C/T cg20307385 chr11:47447363 PSMC3 0.51 11.52 0.41 4.99e-28 Mean corpuscular hemoglobin; BRCA cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg08885076 chr2:99613938 TSGA10 0.46 10.71 0.39 9.63e-25 Chronic sinus infection; BRCA cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs6752107 0.967 rs12162308 chr2:234172188 C/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.51 0.41 5.66e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7412746 0.611 rs10888394 chr1:150749913 C/T cg18016565 chr1:150552671 MCL1 0.34 7.88 0.3 1.39e-14 Melanoma; BRCA cis rs870825 0.698 rs28412823 chr4:185638829 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.46 0.57 3.99e-56 Blood protein levels; BRCA trans rs11976180 1.000 rs11975942 chr7:143740580 T/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.49 -8.85 -0.33 8.5e-18 Obesity-related traits; BRCA cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.49 -0.35 4.4e-20 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs9979545 chr21:46679805 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.48 0.47 1.32e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8028182 0.636 rs28783769 chr15:75849009 C/A cg20655648 chr15:75932815 IMP3 0.45 8.79 0.33 1.41e-17 Sudden cardiac arrest; BRCA cis rs514406 0.607 rs11206000 chr1:53205923 A/C cg16325326 chr1:53192061 ZYG11B -0.71 -18.48 -0.59 2.16e-61 Monocyte count; BRCA trans rs3733585 0.673 rs4292332 chr4:9953830 C/A cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 8.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg16339924 chr4:17578868 LAP3 0.63 15.74 0.53 2.01e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4819052 0.851 rs4819043 chr21:46660078 G/A cg11663144 chr21:46675770 NA -0.62 -14.66 -0.5 3.53e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg19847866 chr10:1019161 NA 0.52 10.66 0.39 1.52e-24 Response to angiotensin II receptor blocker therapy; BRCA trans rs11098499 0.604 rs2389886 chr4:120570422 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.06 0.4 3.92e-26 Corneal astigmatism; BRCA cis rs6820391 1.000 rs17660253 chr4:54414365 G/T cg04173182 chr4:54446035 LNX1 0.4 8.03 0.3 4.64e-15 Cervical artery dissection; BRCA cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.76 0.36 4.52e-21 Menopause (age at onset); BRCA cis rs11098499 0.863 rs12508173 chr4:120318526 T/C cg09307838 chr4:120376055 NA 0.73 15.87 0.53 4.5e-48 Corneal astigmatism; BRCA cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.84 0.36 2.35e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2404602 0.647 rs11072616 chr15:76985269 T/C cg23625390 chr15:77176239 SCAPER -0.58 -14.84 -0.51 4.95e-43 Blood metabolite levels; BRCA trans rs12310956 0.532 rs10844715 chr12:33968444 A/G cg26384229 chr12:38710491 ALG10B 0.47 10.36 0.38 2.37e-23 Morning vs. evening chronotype; BRCA cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg22906224 chr7:99728672 NA 0.44 8.6 0.32 6.33e-17 Coronary artery disease; BRCA cis rs6435161 1.000 rs7568438 chr2:203547106 C/T cg18429434 chr2:203499731 FAM117B -0.45 -8.94 -0.33 4.07e-18 Total cholesterol levels; BRCA cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg00012203 chr2:219082015 ARPC2 -0.48 -9.18 -0.34 5.88e-19 Colorectal cancer; BRCA trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.520 rs160645 chr7:65556307 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.42 -0.38 1.39e-23 Aortic root size; BRCA cis rs9733 0.527 rs11204694 chr1:150653391 G/A cg17724175 chr1:150552817 MCL1 0.27 8.96 0.33 3.51e-18 Tonsillectomy; BRCA cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg10011062 chr15:43941034 CATSPER2 -0.54 -7.94 -0.3 9.19e-15 Lung cancer in ever smokers; BRCA cis rs4319547 0.698 rs4039670 chr12:122822655 A/G cg23029597 chr12:123009494 RSRC2 -0.59 -11.45 -0.41 9.35e-28 Body mass index; BRCA cis rs2637030 0.502 rs1844698 chr5:52970339 G/A cg06476337 chr5:52856530 NDUFS4 0.35 7.96 0.3 8.08e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs514406 0.698 rs567880 chr1:53348564 T/G cg08859206 chr1:53392774 SCP2 -0.61 -13.6 -0.47 3.57e-37 Monocyte count; BRCA cis rs17253792 0.822 rs8006705 chr14:56171283 C/T cg01858014 chr14:56050164 KTN1 -0.57 -8.77 -0.33 1.58e-17 Putamen volume; BRCA cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg23933602 chr10:16859644 RSU1 0.55 8.93 0.33 4.38e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs9287719 0.967 rs6432113 chr2:10744889 C/T cg02196655 chr2:10830764 NOL10 0.3 7.99 0.3 6.55e-15 Prostate cancer; BRCA trans rs2727020 0.930 rs1164686 chr11:49291822 C/T cg03929089 chr4:120376271 NA 0.71 14.67 0.5 3.26e-42 Coronary artery disease; BRCA cis rs477692 0.967 rs488143 chr10:131407369 A/C cg05714579 chr10:131428358 MGMT 0.56 13.43 0.47 2.03e-36 Response to temozolomide; BRCA cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.25e-23 Motion sickness; BRCA cis rs6963495 0.818 rs73190166 chr7:105159955 G/A cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2992756 0.663 rs2992755 chr1:18807897 C/G cg14356550 chr1:18808102 KLHDC7A -0.42 -8.9 -0.33 5.65e-18 Breast cancer; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg22638593 chr5:131593259 PDLIM4 0.32 7.97 0.3 7.08e-15 Acylcarnitine levels; BRCA cis rs1403694 0.695 rs13095338 chr3:186435583 T/C cg12454167 chr3:186435060 KNG1 0.3 8.02 0.3 5.09e-15 Blood protein levels; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg24101359 chr6:42928495 GNMT 0.54 12.66 0.45 5.91e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.53 -9.19 -0.34 5.28e-19 Renal function-related traits (BUN); BRCA cis rs198389 0.617 rs503040 chr1:11890695 C/T cg24844545 chr1:11908347 NPPA -0.32 -8.31 -0.31 5.77e-16 B-type natriuretic peptide levels;NT-proBNP levels in acute coronary syndrome; BRCA cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.89e-18 Motion sickness; BRCA cis rs1829883 0.931 rs7720138 chr5:98879849 G/C cg08333243 chr5:99726346 NA 0.37 8.8 0.33 1.29e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg15112475 chr7:1198522 ZFAND2A -0.55 -13.34 -0.47 5.47e-36 Longevity;Endometriosis; BRCA cis rs1113500 0.897 rs2336127 chr1:108640870 G/A cg06207961 chr1:108661230 NA 0.46 11.13 0.4 1.97e-26 Growth-regulated protein alpha levels; BRCA cis rs427394 0.659 rs274678 chr5:6752385 A/G cg10857441 chr5:6722123 POLS 0.31 9.91 0.36 1.3e-21 Menopause (age at onset); BRCA cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.57 11.64 0.42 1.58e-28 Hip circumference adjusted for BMI; BRCA cis rs897080 0.552 rs1067384 chr2:44644554 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 9.56 0.35 2.51e-20 Height; BRCA cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs6426558 0.621 rs7521639 chr1:227223736 T/C cg10327440 chr1:227177885 CDC42BPA 0.75 17.16 0.56 1.43e-54 Neutrophil percentage of white cells; BRCA cis rs12545109 0.765 rs2576594 chr8:57412126 T/G cg09654669 chr8:57350985 NA -0.41 -7.9 -0.3 1.21e-14 Obesity-related traits; BRCA cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg10802521 chr3:52805072 NEK4 -0.31 -7.9 -0.3 1.26e-14 Bipolar disorder; BRCA cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg11890956 chr21:40555474 PSMG1 0.95 21.62 0.65 3.42e-78 Cognitive function; BRCA cis rs477692 1.000 rs485576 chr10:131425496 G/C cg05714579 chr10:131428358 MGMT 0.59 14.4 0.49 6.55e-41 Response to temozolomide; BRCA cis rs7086627 0.506 rs10749575 chr10:82136921 C/T cg00277334 chr10:82204260 NA -0.45 -9.56 -0.35 2.56e-20 Post bronchodilator FEV1; BRCA cis rs6087990 0.701 rs1997797 chr20:31387954 C/G cg13636640 chr20:31349939 DNMT3B 0.6 16.64 0.55 6.56e-52 Ulcerative colitis; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg08132940 chr7:1081526 C7orf50 -0.49 -7.89 -0.3 1.36e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7662987 0.517 rs1311617 chr4:100012425 T/G cg13256891 chr4:100009986 ADH5 0.54 10.14 0.37 1.65e-22 Smoking initiation; BRCA cis rs919433 1.000 rs2889363 chr2:198163699 A/G cg10820045 chr2:198174542 NA -0.42 -9.62 -0.36 1.47e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4308124 0.708 rs6747657 chr2:112003163 C/T cg04571233 chr2:111982156 NA -0.45 -9.99 -0.37 6.43e-22 Vitiligo; BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.51 8.49 0.32 1.43e-16 Renal function-related traits (BUN); BRCA cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.66 -0.61 1.12e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg23505145 chr19:12996616 KLF1 -0.5 -11.52 -0.41 4.77e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs7903847 0.642 rs3814553 chr10:99155984 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.72 -0.33 2.41e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg13770153 chr20:60521292 NA -0.44 -9.92 -0.37 1.12e-21 Body mass index; BRCA trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg11707556 chr5:10655725 ANKRD33B 0.39 9.36 0.35 1.29e-19 Coronary artery disease; BRCA cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg07606381 chr6:8435919 SLC35B3 0.64 14.19 0.49 6.41e-40 Motion sickness; BRCA trans rs12579753 0.833 rs12579530 chr12:82163930 A/C cg07923666 chr12:49932857 KCNH3 -0.4 -8.1 -0.31 2.77e-15 Resting heart rate; BRCA cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg06784218 chr1:46089804 CCDC17 -0.42 -9.71 -0.36 7.19e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg16425592 chr11:842748 TSPAN4;POLR2L -0.66 -15.18 -0.51 1.13e-44 Mean platelet volume; BRCA cis rs7246657 0.722 rs2909093 chr19:38199462 T/C cg14683738 chr19:37701593 ZNF585B -0.48 -8.03 -0.3 4.74e-15 Coronary artery calcification; BRCA cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11890956 chr21:40555474 PSMG1 -0.61 -13.7 -0.48 1.26e-37 Menarche (age at onset); BRCA cis rs12458462 0.859 rs35493271 chr18:77448793 G/T cg23301140 chr18:77439876 CTDP1 0.34 7.81 0.3 2.38e-14 Monocyte count; BRCA cis rs9818758 0.607 rs9880088 chr3:49178990 G/A cg01304814 chr3:48885189 PRKAR2A 0.63 7.84 0.3 1.91e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7523050 0.730 rs7519107 chr1:109399367 A/C cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs1580019 0.813 rs2044839 chr7:32500805 A/C cg06627557 chr7:32535165 LSM5;AVL9 0.89 19.92 0.62 4.83e-69 Cognitive ability; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg24101359 chr6:42928495 GNMT 0.53 12.54 0.44 2.16e-32 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg13010199 chr12:38710504 ALG10B 0.53 10.79 0.39 4.56e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs10899021 1.000 rs11236201 chr11:74375633 A/G cg25880958 chr11:74394337 NA -0.72 -9.39 -0.35 1.03e-19 Response to metformin (IC50); BRCA cis rs6089829 0.962 rs7267951 chr20:61665979 A/G cg08045932 chr20:61659980 NA 0.49 11.18 0.4 1.31e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg11266682 chr4:10021025 SLC2A9 0.45 12.09 0.43 1.91e-30 Bone mineral density; BRCA cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.26 0.41 6.07e-27 Hip circumference adjusted for BMI; BRCA cis rs965469 1.000 rs2236104 chr20:3277602 C/A cg25506879 chr20:3388711 C20orf194 -0.54 -10.44 -0.38 1.13e-23 IFN-related cytopenia; BRCA trans rs61931739 0.517 rs7958856 chr12:34294737 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.51 0.35 3.76e-20 Morning vs. evening chronotype; BRCA cis rs4803468 1.000 rs2241709 chr19:41912250 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -25.23 -0.71 5.23e-98 Height; BRCA cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24308560 chr3:49941425 MST1R 0.4 8.43 0.32 2.21e-16 Intelligence (multi-trait analysis); BRCA cis rs4664304 0.620 rs3951216 chr2:160711045 G/C cg01092293 chr2:160761427 LY75 0.33 7.95 0.3 8.35e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs559928 1.000 rs72926050 chr11:64143574 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 9.65 0.36 1.21e-20 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs400736 0.671 rs2472862 chr1:7991203 G/A cg25007680 chr1:8021821 PARK7 -0.42 -10.51 -0.38 6.25e-24 Response to antidepressants and depression; BRCA cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg25019033 chr10:957182 NA -0.42 -8.82 -0.33 1.05e-17 Eosinophil percentage of granulocytes; BRCA cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA trans rs3733585 0.699 rs4588456 chr4:9963895 A/T cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg00078996 chr12:132293329 NA -0.45 -11.33 -0.41 2.9e-27 Migraine; BRCA cis rs654128 0.640 rs339333 chr6:117211809 T/G cg12892004 chr6:117198278 RFX6 -0.45 -8.23 -0.31 1.05e-15 Telomere length; BRCA cis rs1451375 1.000 rs1966839 chr7:50627101 T/C cg18232548 chr7:50535776 DDC 0.43 10.14 0.37 1.62e-22 Malaria; BRCA cis rs9311474 0.713 rs352170 chr3:52236077 A/G cg15698299 chr3:52233019 ALAS1 -0.4 -9.31 -0.35 1.99e-19 Electroencephalogram traits; BRCA cis rs68170813 0.559 rs12537733 chr7:106965447 A/T cg02696742 chr7:106810147 HBP1 -0.52 -9.01 -0.34 2.45e-18 Coronary artery disease; BRCA cis rs2882667 0.964 rs2288824 chr5:138298396 C/T cg04439458 chr5:138467593 SIL1 -0.35 -9.27 -0.34 2.72e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.99 0.3 6.15e-15 Depression; BRCA cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.52 11.38 0.41 1.8e-27 Personality dimensions; BRCA cis rs12760731 0.565 rs12028024 chr1:178087423 G/T cg00404053 chr1:178313656 RASAL2 0.67 8.02 0.3 5.06e-15 Obesity-related traits; BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg00106254 chr7:1943704 MAD1L1 -0.45 -11.79 -0.42 3.69e-29 Bipolar disorder and schizophrenia; BRCA cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg25358565 chr5:93447407 FAM172A 1.16 18.43 0.59 3.76e-61 Diabetic retinopathy; BRCA cis rs7188861 0.768 rs441349 chr16:11371759 C/T cg01510278 chr16:11456238 NA 0.42 8.21 0.31 1.2e-15 HDL cholesterol; BRCA cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg11890956 chr21:40555474 PSMG1 -0.6 -13.49 -0.47 1.12e-36 Menarche (age at onset); BRCA cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg25208724 chr1:156163844 SLC25A44 1.04 34.06 0.8 9.05e-146 Testicular germ cell tumor; BRCA cis rs265548 0.538 rs36688 chr19:17911212 A/C cg16024904 chr19:17905718 B3GNT3 0.4 8.26 0.31 8.2e-16 Tumor biomarkers; BRCA cis rs4074536 0.622 rs114150777 chr1:116322834 A/C cg21648376 chr1:116311395 CASQ2 -0.53 -8.81 -0.33 1.22e-17 QRS duration; BRCA cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg06238570 chr21:40685208 BRWD1 -0.41 -8.42 -0.32 2.55e-16 Menarche (age at onset); BRCA cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg00290607 chr11:67383545 NA -0.53 -11.49 -0.41 6.59e-28 Mean corpuscular volume; BRCA cis rs7772486 0.720 rs4896844 chr6:146075224 T/C cg13319975 chr6:146136371 FBXO30 0.43 10.01 0.37 5.33e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs12618769 0.652 rs3754875 chr2:99202747 C/G cg10123293 chr2:99228465 UNC50 0.43 8.51 0.32 1.2e-16 Bipolar disorder; BRCA cis rs4530754 0.691 rs171777 chr5:123053647 C/T cg27365991 chr5:123036376 NA -0.48 -11.26 -0.41 6.08e-27 LDL cholesterol;Total cholesterol levels;Cholesterol, total;LDL cholesterol levels; BRCA cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 8.98e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2070488 0.804 rs13100195 chr3:38482539 A/G cg24069376 chr3:38537580 EXOG 0.34 9.41 0.35 8.96e-20 Electrocardiographic conduction measures; BRCA trans rs931812 0.691 rs884488 chr8:101898523 C/G cg20993868 chr7:22813445 NA 0.43 12.56 0.44 1.69e-32 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs7412746 0.658 rs2230061 chr1:150727539 G/A cg18016565 chr1:150552671 MCL1 0.35 7.96 0.3 7.62e-15 Melanoma; BRCA cis rs782590 0.934 rs17369191 chr2:55757885 T/C cg18811423 chr2:55921094 PNPT1 0.72 22.98 0.67 1.28e-85 Metabolic syndrome; BRCA cis rs950169 0.545 rs4842841 chr15:84641125 G/A cg17507749 chr15:85114479 UBE2QP1 0.54 9.23 0.34 3.98e-19 Schizophrenia; BRCA trans rs208520 0.690 rs12198297 chr6:66714665 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 20.37 0.63 1.92e-71 Exhaled nitric oxide output; BRCA cis rs2276314 0.857 rs62101379 chr18:33584902 G/A cg05985134 chr18:33552581 C18orf21 0.64 11.6 0.42 2.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg06494592 chr3:125709126 NA -0.54 -8.41 -0.32 2.67e-16 Blood pressure (smoking interaction); BRCA cis rs1451375 0.617 rs11772714 chr7:50542843 G/A cg18232548 chr7:50535776 DDC -0.42 -8.84 -0.33 9.24e-18 Malaria; BRCA cis rs7100689 0.646 rs6585967 chr10:82139791 A/G cg01528321 chr10:82214614 TSPAN14 -0.82 -18.17 -0.58 8.4e-60 Post bronchodilator FEV1; BRCA cis rs3862030 0.839 rs2274351 chr10:104264107 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -11.89 -0.43 1.3e-29 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs1505368 0.789 rs13419353 chr2:213271459 A/T cg16329650 chr2:213403929 ERBB4 -0.32 -7.96 -0.3 7.65e-15 Symmetrical dimethylarginine levels; BRCA trans rs4718428 0.672 rs4718412 chr7:66286867 C/T cg18876405 chr7:65276391 NA -0.41 -7.86 -0.3 1.69e-14 Corneal structure; BRCA cis rs6700896 0.864 rs56274111 chr1:66128511 A/C cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg23422044 chr7:1970798 MAD1L1 -0.56 -9.65 -0.36 1.15e-20 Neuroticism; BRCA cis rs13102973 0.863 rs13103492 chr4:135907685 A/C cg14419869 chr4:135874104 NA 0.45 8.99 0.34 2.73e-18 Subjective well-being; BRCA cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg23283495 chr1:209979779 IRF6 0.38 8.88 0.33 6.55e-18 Cleft lip with or without cleft palate; BRCA cis rs9290065 0.519 rs956447 chr3:160668917 G/C cg03342759 chr3:160939853 NMD3 -0.53 -11.24 -0.41 7.45e-27 Kawasaki disease; BRCA cis rs7829975 0.577 rs940030 chr8:8546928 A/G cg06636001 chr8:8085503 FLJ10661 -0.45 -9.09 -0.34 1.21e-18 Mood instability; BRCA cis rs11191205 0.644 rs10883664 chr10:103368208 C/T cg15320455 chr10:103880129 LDB1 0.48 8.15 0.31 1.92e-15 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.913 rs10006304 chr4:120124305 A/G cg25214090 chr10:38739885 LOC399744 0.53 10.84 0.39 3.02e-25 Corneal astigmatism; BRCA trans rs2204008 0.744 rs11182316 chr12:38499552 G/A cg06521331 chr12:34319734 NA -0.52 -9.36 -0.35 1.32e-19 Bladder cancer; BRCA trans rs4650994 0.525 rs10913567 chr1:178511941 A/C cg05059571 chr16:84539110 KIAA1609 -0.58 -13.13 -0.46 5.07e-35 HDL cholesterol levels;HDL cholesterol; BRCA cis rs1707322 1.000 rs6429580 chr1:46275648 A/G cg03146154 chr1:46216737 IPP 0.46 10.12 0.37 2e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs6951245 0.872 rs77569514 chr7:1085508 G/A cg13565492 chr6:43139072 SRF -0.79 -11.0 -0.4 6.8e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg25319279 chr11:5960081 NA -0.4 -8.88 -0.33 6.81e-18 DNA methylation (variation); BRCA cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.67 10.4 0.38 1.6e-23 Schizophrenia; BRCA cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.73 21.33 0.64 1.16e-76 Age-related macular degeneration (geographic atrophy); BRCA cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.43 -9.32 -0.35 1.86e-19 Colorectal cancer; BRCA cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.0 -12.71 -0.45 3.62e-33 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4409675 0.619 rs12070173 chr1:28231955 G/C cg23691781 chr1:28212827 C1orf38 0.32 10.71 0.39 9.82e-25 Corneal astigmatism; BRCA cis rs9470366 0.816 rs4331968 chr6:36623243 A/T cg08179530 chr6:36648295 CDKN1A 0.5 10.31 0.38 3.65e-23 QRS duration; BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg16606324 chr3:10149918 C3orf24 0.56 9.97 0.37 7.35e-22 Alzheimer's disease; BRCA cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg00677455 chr12:58241039 CTDSP2 0.63 14.19 0.49 6.18e-40 Multiple sclerosis; BRCA cis rs61931739 0.500 rs11053290 chr12:34582392 C/T cg06521331 chr12:34319734 NA 0.53 10.32 0.38 3.44e-23 Morning vs. evening chronotype; BRCA cis rs11190604 0.767 rs7085426 chr10:102163640 T/C cg07080220 chr10:102295463 HIF1AN 0.48 10.21 0.37 8.66e-23 Palmitoleic acid (16:1n-7) levels; BRCA trans rs11039798 0.614 rs2174703 chr11:48788242 G/A cg15704280 chr7:45808275 SEPT13 0.6 8.83 0.33 9.87e-18 Axial length; BRCA cis rs10782582 0.593 rs77208152 chr1:76124255 T/C cg10523679 chr1:76189770 ACADM -0.47 -9.13 -0.34 9.04e-19 Daytime sleep phenotypes; BRCA cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg01874867 chr7:94954059 PON1 -0.4 -8.28 -0.31 7.03e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs11098499 0.954 rs2389802 chr4:120325732 C/A cg25214090 chr10:38739885 LOC399744 0.55 12.51 0.44 2.82e-32 Corneal astigmatism; BRCA cis rs7011049 1.000 rs28867471 chr8:53838179 C/T cg26025543 chr8:53854495 NA 0.53 9.48 0.35 4.84e-20 Systolic blood pressure; BRCA cis rs6831352 0.918 rs34805407 chr4:100050786 C/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs2073300 0.609 rs56334525 chr20:23365812 A/G cg12062639 chr20:23401060 NAPB 0.94 13.32 0.47 6.43e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg00530320 chr1:46809349 NSUN4 0.49 9.67 0.36 9.57e-21 Menopause (age at onset); BRCA cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg08885076 chr2:99613938 TSGA10 0.44 10.21 0.37 8.7e-23 Chronic sinus infection; BRCA cis rs2404602 0.583 rs2469542 chr15:76557476 A/G cg26408565 chr15:76604113 ETFA 0.51 11.53 0.41 4.52e-28 Blood metabolite levels; BRCA cis rs3008870 0.651 rs2815376 chr1:67508531 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.48 10.06 0.37 3.4e-22 Lymphocyte percentage of white cells; BRCA cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.53 10.82 0.39 3.76e-25 Multiple sclerosis; BRCA trans rs208520 1.000 rs12190316 chr6:66973365 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 11.89 0.43 1.3e-29 Exhaled nitric oxide output; BRCA trans rs7613875 0.641 rs2624845 chr3:50062437 C/A cg21659725 chr3:3221576 CRBN -0.33 -7.87 -0.3 1.48e-14 Body mass index; BRCA cis rs67311347 1.000 rs962847 chr3:40495156 A/G cg09455208 chr3:40491958 NA -0.48 -11.89 -0.43 1.39e-29 Renal cell carcinoma; BRCA cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.87 -0.33 7.2e-18 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg21770322 chr7:97807741 LMTK2 0.43 11.28 0.41 4.71e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs9323205 0.954 rs4258524 chr14:51638739 A/T cg23942311 chr14:51606299 NA -0.39 -9.08 -0.34 1.35e-18 Cancer; BRCA cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs4363385 0.747 rs946101 chr1:152972032 C/T cg24667326 chr1:152973720 SPRR3 0.34 9.59 0.35 1.87e-20 Inflammatory skin disease; BRCA cis rs67460515 0.500 rs964533 chr3:160749019 C/A cg03342759 chr3:160939853 NMD3 -0.57 -11.31 -0.41 3.61e-27 Parkinson's disease; BRCA cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg02017074 chr12:117425053 FBXW8 0.6 11.29 0.41 4.56e-27 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs6582630 0.572 rs1969363 chr12:38514872 A/G cg26384229 chr12:38710491 ALG10B 0.48 11.47 0.41 8.25e-28 Drug-induced liver injury (flucloxacillin); BRCA cis rs1865760 0.534 rs2032444 chr6:26046744 T/G cg16482183 chr6:26056742 HIST1H1C 0.66 13.39 0.47 3.11e-36 Height; BRCA cis rs7914558 0.505 rs12260436 chr10:104741114 A/C cg04362960 chr10:104952993 NT5C2 0.46 10.22 0.37 8.08e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9287719 0.901 rs13034017 chr2:10739592 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs801193 0.569 rs2659893 chr7:66199993 G/A cg11764359 chr7:65958608 NA 0.75 16.82 0.55 8.27e-53 Aortic root size; BRCA trans rs2840044 1.000 rs9900378 chr17:33911302 C/T cg19694781 chr19:47549865 TMEM160 0.45 10.47 0.38 8.73e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs2625529 0.775 rs4777466 chr15:72136872 C/T cg16672083 chr15:72433130 SENP8 -0.67 -15.85 -0.53 5.53e-48 Red blood cell count; BRCA cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.44 0.63 8.2e-72 Chronic sinus infection; BRCA cis rs7095944 0.584 rs10901814 chr10:126431281 G/C cg08799069 chr10:126477246 METTL10 -0.38 -9.01 -0.34 2.36e-18 Asthma; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.46 -0.32 1.88e-16 Total body bone mineral density; BRCA cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg00409905 chr10:38381863 ZNF37A 0.44 8.88 0.33 6.52e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg02574844 chr11:5959923 NA -0.43 -8.05 -0.3 4.1e-15 DNA methylation (variation); BRCA cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs782590 0.721 rs1084525 chr2:55929430 C/T cg18811423 chr2:55921094 PNPT1 0.77 25.92 0.72 8.56e-102 Metabolic syndrome; BRCA trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg13010199 chr12:38710504 ALG10B 0.49 9.57 0.35 2.32e-20 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs2424700 chr20:25266513 A/G cg08601574 chr20:25228251 PYGB 0.35 8.36 0.31 3.81e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs3733585 0.699 rs6834893 chr4:9959123 C/T cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs2404602 0.583 rs11072580 chr15:76540231 G/A cg22467129 chr15:76604101 ETFA -0.54 -12.73 -0.45 3.05e-33 Blood metabolite levels; BRCA cis rs6762477 0.748 rs3755831 chr3:50228767 G/T cg05623727 chr3:50126028 RBM5 -0.38 -8.68 -0.32 3.18e-17 Menarche (age at onset); BRCA cis rs877282 0.838 rs11253408 chr10:796374 T/C cg17470449 chr10:769945 NA 0.51 8.71 0.33 2.54e-17 Uric acid levels; BRCA cis rs11098499 0.955 rs56386062 chr4:120155135 T/C cg09307838 chr4:120376055 NA 0.6 11.86 0.42 1.77e-29 Corneal astigmatism; BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg13628971 chr7:2884303 GNA12 0.46 9.14 0.34 7.93e-19 Height; BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.55 -0.32 8.82e-17 Total body bone mineral density; BRCA cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg10295955 chr4:187884368 NA -0.76 -20.75 -0.63 1.69e-73 Lobe attachment (rater-scored or self-reported); BRCA cis rs7647973 1.000 rs74471041 chr3:49542543 T/G cg07636037 chr3:49044803 WDR6 -0.74 -16.07 -0.54 4.89e-49 Menarche (age at onset); BRCA trans rs61931739 0.500 rs11053167 chr12:34387092 A/C cg13010199 chr12:38710504 ALG10B 0.48 9.36 0.35 1.31e-19 Morning vs. evening chronotype; BRCA cis rs6820391 0.816 rs4418038 chr4:54446302 A/G cg04173182 chr4:54446035 LNX1 0.52 11.64 0.42 1.62e-28 Cervical artery dissection; BRCA trans rs61931739 0.500 rs11053217 chr12:34470036 A/C cg13010199 chr12:38710504 ALG10B 0.43 9.14 0.34 7.97e-19 Morning vs. evening chronotype; BRCA cis rs7560272 0.501 rs12615807 chr2:73947583 T/C cg20560298 chr2:73613845 ALMS1 0.33 8.44 0.32 2.13e-16 Schizophrenia; BRCA cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.23 0.68 5.59e-87 Chronic sinus infection; BRCA cis rs3820928 1.000 rs12615988 chr2:227769000 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -8.89 -0.33 6.22e-18 Pulmonary function; BRCA cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.644 rs3986377 chr4:120260270 G/A cg25214090 chr10:38739885 LOC399744 0.43 10.02 0.37 4.62e-22 Corneal astigmatism; BRCA cis rs2180341 0.751 rs9388553 chr6:127574044 A/G cg24812749 chr6:127587940 RNF146 0.75 16.47 0.55 4.43e-51 Breast cancer; BRCA cis rs113835537 0.529 rs11227503 chr11:66275242 G/C cg24851651 chr11:66362959 CCS 0.44 8.3 0.31 6.33e-16 Airway imaging phenotypes; BRCA trans rs6479891 0.908 rs7078456 chr10:65269479 C/T cg14819942 chr15:35414228 NA -0.33 -8.33 -0.31 4.85e-16 Arthritis (juvenile idiopathic); BRCA cis rs4268898 0.662 rs35624938 chr2:24576651 T/C cg08917208 chr2:24149416 ATAD2B 0.51 8.06 0.3 3.89e-15 Asthma; BRCA cis rs631288 0.793 rs1530337 chr1:146683319 C/A cg25205988 chr1:146714368 CHD1L 0.82 8.01 0.3 5.33e-15 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.65e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8177179 0.967 rs4078166 chr3:133435979 C/A cg24879335 chr3:133465180 TF 0.32 10.62 0.39 2.24e-24 Iron status biomarkers (transferrin levels); BRCA cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs637571 0.544 rs617791 chr11:65702523 C/G cg17712092 chr4:129076599 LARP1B 0.57 13.98 0.48 6.28e-39 Eosinophil percentage of white cells; BRCA cis rs8114671 0.967 rs4911472 chr20:33775377 T/A cg07148914 chr20:33460835 GGT7 0.37 7.92 0.3 1.09e-14 Height; BRCA cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.58 -0.45 1.33e-32 Bipolar disorder; BRCA cis rs2153535 0.601 rs7738877 chr6:8542230 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.72e-18 Motion sickness; BRCA trans rs526821 0.595 rs608964 chr11:55339266 G/A cg15704280 chr7:45808275 SEPT13 -0.43 -8.12 -0.31 2.47e-15 Pediatric bone mineral density (spine); BRCA cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg07817648 chr10:79422355 NA -0.68 -12.54 -0.44 2e-32 Bone mineral density; BRCA cis rs7847628 0.566 rs10739575 chr9:123606101 A/G cg03808351 chr9:123631620 PHF19 -0.55 -8.26 -0.31 8.19e-16 Birth weight; BRCA cis rs7267979 1.000 rs422424 chr20:25445446 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.46 -9.83 -0.36 2.47e-21 Bipolar disorder; BRCA cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.52 9.21 0.34 4.65e-19 Mean platelet volume; BRCA cis rs312273 0.806 rs12296676 chr12:41348067 T/G cg17827154 chr12:41323612 CNTN1 -0.41 -10.81 -0.39 3.94e-25 Bipolar disorder; BRCA cis rs7020830 0.522 rs10814509 chr9:37111057 A/G cg14294708 chr9:37120828 ZCCHC7 0.8 18.84 0.6 2.54e-63 Schizophrenia; BRCA cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg00071950 chr4:10020882 SLC2A9 0.54 13.45 0.47 1.71e-36 Bone mineral density; BRCA cis rs1468333 0.929 rs2107682 chr5:137543135 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.32 0.31 5.43e-16 Resting heart rate; BRCA cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg23033748 chr14:75592666 NEK9 -0.43 -10.12 -0.37 1.97e-22 Height; BRCA trans rs629535 0.773 rs489206 chr8:70064883 T/C cg21567404 chr3:27674614 NA 1.01 20.79 0.64 9.62e-74 Dupuytren's disease; BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24549020 chr5:56110836 MAP3K1 0.64 13.25 0.46 1.38e-35 Initial pursuit acceleration; BRCA cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg11752832 chr7:134001865 SLC35B4 0.5 12.1 0.43 1.79e-30 Mean platelet volume; BRCA cis rs78456975 0.527 rs11884165 chr2:1561052 A/G cg26248373 chr2:1572462 NA -0.58 -13.04 -0.46 1.26e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.57 0.35 2.33e-20 Bipolar disorder; BRCA cis rs910316 0.934 rs8016330 chr14:75657507 G/T cg23033748 chr14:75592666 NEK9 -0.38 -9.2 -0.34 5.22e-19 Height; BRCA cis rs12971120 0.891 rs11151960 chr18:72177232 G/A cg25817165 chr18:72167213 CNDP2 -0.72 -12.76 -0.45 2.25e-33 Refractive error; BRCA cis rs34779708 0.931 rs68039650 chr10:35385499 C/A cg03585969 chr10:35415529 CREM 0.56 11.54 0.42 3.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs514406 0.679 rs499239 chr1:53310594 A/G cg27535305 chr1:53392650 SCP2 -0.46 -11.44 -0.41 1.08e-27 Monocyte count; BRCA cis rs1577917 0.682 rs1173417 chr6:86403941 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.46 13.43 0.47 2.22e-36 Response to antipsychotic treatment; BRCA cis rs11190604 1.000 rs11190587 chr10:102266638 C/T cg07080220 chr10:102295463 HIF1AN 0.6 13.28 0.47 1.03e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg05283184 chr6:79620031 NA -0.43 -11.03 -0.4 4.97e-26 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.967 rs7781221 chr7:91664645 A/G cg17063962 chr7:91808500 NA 0.53 12.43 0.44 6.26e-32 Breast cancer; BRCA cis rs4660261 0.526 rs2485997 chr1:44345841 G/C cg12908607 chr1:44402522 ARTN -0.34 -8.21 -0.31 1.27e-15 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.967 rs9403707 chr6:145800010 A/G cg23711669 chr6:146136114 FBXO30 0.65 14.97 0.51 1.22e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467711 0.538 rs36012762 chr6:25980523 A/C cg21479132 chr6:26055353 NA 0.57 7.97 0.3 7.48e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs9462846 0.959 rs9462845 chr6:42860958 A/G cg02353165 chr6:42928485 GNMT 0.49 8.64 0.32 4.47e-17 Blood protein levels; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.85e-20 Tonsillectomy; BRCA cis rs3820928 1.000 rs4675119 chr2:227774635 A/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.53 -0.32 1.09e-16 Pulmonary function; BRCA cis rs854765 0.565 rs4072738 chr17:17884547 A/C cg04398451 chr17:18023971 MYO15A -0.7 -15.31 -0.52 2.77e-45 Total body bone mineral density; BRCA cis rs7666738 0.822 rs17484018 chr4:98988960 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.55e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.546 rs4665976 chr2:27640325 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Total body bone mineral density; BRCA cis rs2242116 0.734 rs4683294 chr3:46979013 C/G cg27129171 chr3:47204927 SETD2 -0.52 -10.72 -0.39 9.04e-25 Birth weight; BRCA cis rs6964587 1.000 rs13230588 chr7:91615427 C/A cg01689657 chr7:91764605 CYP51A1 0.22 7.92 0.3 1.09e-14 Breast cancer; BRCA cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -9.08 -0.34 1.32e-18 Developmental language disorder (linguistic errors); BRCA cis rs9527 0.830 rs12249194 chr10:104643698 T/C cg04362960 chr10:104952993 NT5C2 0.48 10.54 0.38 4.79e-24 Arsenic metabolism; BRCA trans rs2197308 0.765 rs11182481 chr12:37926019 T/C cg06521331 chr12:34319734 NA -0.57 -10.55 -0.39 4.08e-24 Morning vs. evening chronotype; BRCA cis rs2032447 0.839 rs199750 chr6:26016462 A/G cg03517284 chr6:25882590 NA 0.46 9.54 0.35 3.05e-20 Intelligence (multi-trait analysis); BRCA cis rs7843479 0.601 rs10101881 chr8:21830158 A/G cg17168535 chr8:21777572 XPO7 0.59 13.91 0.48 1.23e-38 Mean corpuscular volume; BRCA cis rs6910061 0.789 rs9461490 chr6:11119471 G/A cg27233058 chr6:11094804 LOC221710 0.51 8.64 0.32 4.59e-17 Diabetic kidney disease; BRCA cis rs4713675 0.584 rs4711339 chr6:33667199 A/G cg14003231 chr6:33640908 ITPR3 0.33 8.19 0.31 1.42e-15 Plateletcrit; BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg00166722 chr3:10149974 C3orf24 0.57 11.15 0.4 1.6e-26 Alzheimer's disease; BRCA cis rs9443189 0.570 rs504446 chr6:76326939 T/C cg01950844 chr6:76311363 SENP6 0.85 13.76 0.48 6.17e-38 Prostate cancer; BRCA cis rs3106136 0.527 rs2664894 chr4:95153831 T/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.08 -0.37 2.85e-22 Capecitabine sensitivity; BRCA cis rs208520 0.690 rs4618506 chr6:66756889 A/C cg07460842 chr6:66804631 NA -0.96 -19.18 -0.6 4.27e-65 Exhaled nitric oxide output; BRCA cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg01874867 chr7:94954059 PON1 -0.39 -7.97 -0.3 7.31e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2370759 1.000 rs16933243 chr10:32615135 T/C cg18270830 chr10:32634957 EPC1 0.6 10.28 0.38 4.83e-23 Sexual dysfunction (female); BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.5 10.28 0.38 4.78e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6570726 0.818 rs952405 chr6:145925952 T/C cg23711669 chr6:146136114 FBXO30 0.7 16.34 0.54 2.13e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg10518543 chr12:38710700 ALG10B 0.36 7.94 0.3 9.43e-15 Morning vs. evening chronotype; BRCA cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.17 0.31 1.67e-15 Uric acid levels; BRCA cis rs73086581 0.945 rs6052219 chr20:3970307 A/G cg02187196 chr20:3869020 PANK2 0.51 9.22 0.34 4.42e-19 Response to antidepressants in depression; BRCA cis rs6426558 0.559 rs2813947 chr1:227459413 G/T cg10327440 chr1:227177885 CDC42BPA 0.49 9.67 0.36 9.78e-21 Neutrophil percentage of white cells; BRCA trans rs2204008 0.748 rs11180579 chr12:38237830 A/G cg06521331 chr12:34319734 NA -0.52 -9.41 -0.35 8.45e-20 Bladder cancer; BRCA cis rs875971 0.895 rs4145009 chr7:65726615 T/C cg18876405 chr7:65276391 NA -0.5 -11.16 -0.4 1.46e-26 Aortic root size; BRCA cis rs6582630 0.502 rs11610978 chr12:38356957 C/G cg26384229 chr12:38710491 ALG10B 0.66 15.77 0.53 1.46e-47 Drug-induced liver injury (flucloxacillin); BRCA cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg07414643 chr4:187882934 NA 0.23 7.86 0.3 1.59e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg06636001 chr8:8085503 FLJ10661 0.68 15.22 0.52 7.08e-45 Systolic blood pressure; BRCA cis rs35110281 0.776 rs1073522 chr21:45009219 T/A cg01579765 chr21:45077557 HSF2BP -0.43 -11.52 -0.41 4.86e-28 Mean corpuscular volume; BRCA trans rs11722228 0.522 rs73212880 chr4:10115692 T/A cg26043149 chr18:55253948 FECH 1.11 23.73 0.68 9.8e-90 Gout;Urate levels;Serum uric acid levels; BRCA cis rs13427251 0.903 rs6746402 chr2:100150443 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.51 -12.49 -0.44 3.4e-32 Chronic sinus infection; BRCA trans rs867371 0.502 rs2047679 chr15:82531881 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.31 -8.29 -0.31 6.79e-16 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs61931739 0.534 rs7138522 chr12:34039762 G/A cg06521331 chr12:34319734 NA -0.62 -11.16 -0.4 1.46e-26 Morning vs. evening chronotype; BRCA cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.53 -8.98 -0.33 3.13e-18 Schizophrenia; BRCA cis rs3760982 0.585 rs61013802 chr19:44292142 A/T cg11993925 chr19:44307056 LYPD5 0.37 8.92 0.33 4.75e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs2882667 0.861 rs10075541 chr5:138390318 C/T cg04439458 chr5:138467593 SIL1 -0.33 -9.07 -0.34 1.51e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1468333 1.000 rs2906128 chr5:137550054 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.56 0.32 8.09e-17 Resting heart rate; BRCA cis rs6834538 0.597 rs1486865 chr4:113465651 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.43 10.38 0.38 1.94e-23 Free thyroxine concentration; BRCA trans rs9858542 0.953 rs1801143 chr3:49570200 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.62 -0.36 1.52e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs11608355 0.545 rs1073780 chr12:109895143 T/C cg05360138 chr12:110035743 NA 0.65 10.77 0.39 5.72e-25 Neuroticism; BRCA cis rs6952809 0.532 rs7803015 chr7:2432143 G/A cg23289794 chr7:2394357 EIF3B -0.45 -9.36 -0.35 1.31e-19 Multiple sclerosis; BRCA cis rs4242434 0.892 rs34269854 chr8:22465160 G/C cg03733263 chr8:22462867 KIAA1967 0.97 23.17 0.68 1.16e-86 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs2243480 1.000 rs4145008 chr7:65647511 T/G cg18252515 chr7:66147081 NA 1.06 15.97 0.53 1.49e-48 Diabetic kidney disease; BRCA cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg08045932 chr20:61659980 NA 0.45 10.39 0.38 1.81e-23 Prostate cancer (SNP x SNP interaction); BRCA cis rs1707322 0.964 rs785483 chr1:46559171 T/C cg03146154 chr1:46216737 IPP -0.43 -9.38 -0.35 1.09e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7937890 1.000 rs2970334 chr11:14329355 C/T cg22961513 chr11:14280813 SPON1 0.31 7.96 0.3 7.63e-15 Mitochondrial DNA levels; BRCA cis rs4389656 0.857 rs2279657 chr5:6737571 A/G cg10857441 chr5:6722123 POLS -0.25 -7.82 -0.3 2.23e-14 Coronary artery disease; BRCA cis rs9341808 0.718 rs6910201 chr6:80904938 G/C cg08355045 chr6:80787529 NA 0.39 9.96 0.37 7.9e-22 Sitting height ratio; BRCA cis rs3806933 0.522 rs11241100 chr5:110460958 C/T cg04022379 chr5:110408740 TSLP 0.48 10.15 0.37 1.55e-22 Eosinophilic esophagitis; BRCA cis rs9291683 0.546 rs13129453 chr4:10044784 T/C cg11266682 chr4:10021025 SLC2A9 0.45 11.99 0.43 4.9e-30 Bone mineral density; BRCA cis rs9486719 1.000 rs2263192 chr6:96873037 C/G cg06623918 chr6:96969491 KIAA0776 0.73 12.97 0.46 2.56e-34 Migraine;Coronary artery disease; BRCA cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg06238570 chr21:40685208 BRWD1 -0.42 -8.62 -0.32 5.25e-17 Menarche (age at onset); BRCA cis rs7172677 0.737 rs11855234 chr15:75446834 C/A cg14664628 chr15:75095509 CSK -0.41 -8.87 -0.33 7.47e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg08807101 chr21:30365312 RNF160 -0.59 -15.16 -0.51 1.39e-44 Dental caries; BRCA cis rs1153858 1.000 rs12595087 chr15:45655232 A/G cg21132104 chr15:45694354 SPATA5L1 0.76 17.26 0.56 4.5e-55 Homoarginine levels; BRCA cis rs6815814 0.904 rs73236628 chr4:38825443 C/T cg02016764 chr4:38805732 TLR1 -0.56 -8.5 -0.32 1.34e-16 Breast cancer; BRCA cis rs7178424 1.000 rs17205407 chr15:62372827 A/G cg00456672 chr15:62358751 C2CD4A 0.37 8.83 0.33 1.03e-17 Height; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.98e-16 Total body bone mineral density; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs875971 0.862 rs10278014 chr7:66051264 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.82 -0.3 2.16e-14 Aortic root size; BRCA trans rs9914544 0.966 rs1737943 chr17:18841590 A/G cg04702396 chr17:15466718 FAM18B2 -0.37 -7.82 -0.3 2.26e-14 Educational attainment (years of education); BRCA cis rs6088590 1.000 rs6088607 chr20:33378733 C/T cg24642439 chr20:33292090 TP53INP2 0.69 15.99 0.53 1.23e-48 Coronary artery disease; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg25036284 chr2:26402008 FAM59B -0.89 -15.63 -0.53 7.3e-47 Gut microbiome composition (summer); BRCA cis rs4820539 1.000 rs4822362 chr22:23482744 C/A cg14186256 chr22:23484241 RTDR1 0.79 24.29 0.69 8.25e-93 Bone mineral density; BRCA cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg00074818 chr8:8560427 CLDN23 -0.39 -8.49 -0.32 1.46e-16 Obesity-related traits; BRCA cis rs9287719 0.967 rs7587114 chr2:10739963 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg25237894 chr2:233734115 C2orf82 -0.41 -11.83 -0.42 2.37e-29 Coronary artery disease; BRCA cis rs12431939 1.000 rs7140375 chr14:51637242 T/G cg23942311 chr14:51606299 NA -0.42 -8.2 -0.31 1.27e-15 Cancer; BRCA cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.62 9.66 0.36 1.08e-20 Lung function (FEV1/FVC); BRCA cis rs7552404 1.000 rs6672180 chr1:76123973 C/G cg10523679 chr1:76189770 ACADM 0.76 16.01 0.54 9.23e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs11098499 0.866 rs7677068 chr4:120291704 C/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.17 0.31 1.62e-15 Axial length; BRCA cis rs2180341 0.814 rs6914131 chr6:127737489 T/C cg24812749 chr6:127587940 RNF146 0.68 15.58 0.52 1.2e-46 Breast cancer; BRCA cis rs4423214 0.879 rs1790330 chr11:71147825 C/T cg05163923 chr11:71159392 DHCR7 -0.54 -10.94 -0.4 1.22e-25 Vitamin D levels; BRCA cis rs9399137 0.507 rs13214669 chr6:135299959 T/C cg22676075 chr6:135203613 NA 0.45 8.66 0.32 3.86e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs17092148 0.887 rs4302281 chr20:33171645 C/T cg16810054 chr20:33298113 TP53INP2 0.46 10.59 0.39 2.99e-24 Neuroticism; BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg21143896 chr7:2802374 GNA12 -0.33 -8.6 -0.32 6.35e-17 Height; BRCA cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24110177 chr3:50126178 RBM5 0.4 10.99 0.4 7.56e-26 Intelligence (multi-trait analysis); BRCA cis rs6684514 1.000 rs12024813 chr1:156224529 C/A cg16558208 chr1:156270281 VHLL 0.36 8.02 0.3 4.92e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg07828340 chr4:882639 GAK 1.01 14.02 0.49 3.76e-39 Intelligence (multi-trait analysis); BRCA cis rs9399135 0.935 rs949547 chr6:135343499 C/G cg24558204 chr6:135376177 HBS1L 0.45 12.41 0.44 8.13e-32 Red blood cell count; BRCA cis rs2737618 0.722 rs2816978 chr1:200078773 A/G cg21825944 chr1:200113062 NR5A2 -0.4 -9.01 -0.34 2.28e-18 Uric acid levels; BRCA cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg21475434 chr5:93447410 FAM172A 0.66 8.46 0.32 1.89e-16 Diabetic retinopathy; BRCA cis rs6430585 0.527 rs1438303 chr2:136429857 C/T cg07169764 chr2:136633963 MCM6 1.0 19.48 0.61 1.1e-66 Corneal structure; BRCA cis rs7124681 0.584 rs7950674 chr11:47871017 T/C cg20307385 chr11:47447363 PSMC3 0.41 9.47 0.35 5.45e-20 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs4718428 0.672 rs13241598 chr7:66300652 A/G cg18252515 chr7:66147081 NA -0.56 -11.21 -0.41 9.36e-27 Corneal structure; BRCA cis rs2019137 0.936 rs3828189 chr2:113954496 T/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.77 -0.45 2.03e-33 Lymphocyte counts; BRCA cis rs12824058 0.831 rs7299065 chr12:130809661 A/T cg24838063 chr12:130822603 PIWIL1 0.69 16.86 0.55 4.75e-53 Menopause (age at onset); BRCA cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.42 11.44 0.41 1.1e-27 Response to bleomycin (chromatid breaks); BRCA cis rs708547 0.624 rs1718886 chr4:57849251 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.43 11.68 0.42 1.07e-28 Response to bleomycin (chromatid breaks); BRCA cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.47 -11.16 -0.4 1.49e-26 IgG glycosylation; BRCA cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg11941060 chr3:133502564 NA -0.35 -8.01 -0.3 5.44e-15 Iron status biomarkers; BRCA cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.81 -0.36 3.01e-21 Developmental language disorder (linguistic errors); BRCA cis rs7560272 0.538 rs7370393 chr2:73925636 A/C cg20560298 chr2:73613845 ALMS1 0.35 8.97 0.33 3.39e-18 Schizophrenia; BRCA trans rs9329221 0.683 rs814359 chr8:9883132 T/G cg06636001 chr8:8085503 FLJ10661 -0.48 -9.98 -0.37 7.03e-22 Neuroticism; BRCA cis rs11098499 0.820 rs2389885 chr4:120533931 C/T cg09307838 chr4:120376055 NA 0.67 12.42 0.44 6.73e-32 Corneal astigmatism; BRCA cis rs6700896 0.897 rs1938494 chr1:66117691 G/T cg04111102 chr1:66153794 NA 0.34 8.42 0.32 2.57e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6912958 0.712 rs4707383 chr6:88330602 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.41 -0.32 2.67e-16 Monocyte percentage of white cells; BRCA cis rs1348850 0.874 rs2166558 chr2:178373652 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 9.36 0.35 1.3e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg27170947 chr2:26402098 FAM59B -0.78 -12.58 -0.45 1.36e-32 Gut microbiome composition (summer); BRCA cis rs11585357 0.895 rs72633823 chr1:17630779 G/A cg08277548 chr1:17600880 PADI3 -0.75 -12.26 -0.44 3.67e-31 Hair shape; BRCA cis rs57590327 0.503 rs17019299 chr3:81851643 A/G cg07356753 chr3:81810745 GBE1 -0.42 -9.79 -0.36 3.46e-21 Extraversion; BRCA cis rs36051895 0.659 rs3780367 chr9:5068755 T/G cg02405213 chr9:5042618 JAK2 -0.5 -9.09 -0.34 1.22e-18 Pediatric autoimmune diseases; BRCA cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA trans rs783540 0.900 rs55924160 chr15:83282196 C/T cg18393722 chr15:85113863 UBE2QP1 -0.29 -9.09 -0.34 1.23e-18 Schizophrenia; BRCA cis rs7124681 0.584 rs12226590 chr11:47571808 T/C cg20307385 chr11:47447363 PSMC3 0.47 10.57 0.39 3.44e-24 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs9790314 0.695 rs7630763 chr3:160864865 T/C cg03342759 chr3:160939853 NMD3 -0.59 -13.03 -0.46 1.37e-34 Morning vs. evening chronotype; BRCA cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg13319975 chr6:146136371 FBXO30 0.45 10.43 0.38 1.24e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs7605378 0.528 rs281791 chr2:200850402 A/G cg23649088 chr2:200775458 C2orf69 -0.7 -15.24 -0.52 5.71e-45 Osteoporosis; BRCA cis rs6121246 0.559 rs6060857 chr20:30300222 A/G cg21427119 chr20:30132790 HM13 -0.35 -7.9 -0.3 1.18e-14 Mean corpuscular hemoglobin; BRCA cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg12311346 chr5:56204834 C5orf35 -0.46 -9.34 -0.35 1.64e-19 Coronary artery disease; BRCA cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.85 -0.36 2.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg25237894 chr2:233734115 C2orf82 -0.41 -11.81 -0.42 3.12e-29 Coronary artery disease; BRCA cis rs7917772 0.503 rs7914389 chr10:104295402 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs17253792 0.731 rs79483151 chr14:56048851 C/T cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.29e-20 Putamen volume; BRCA cis rs12477438 0.834 rs1563108 chr2:99701153 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.59 -13.39 -0.47 3.23e-36 Chronic sinus infection; BRCA cis rs2625529 0.938 rs4777464 chr15:72131763 C/T cg16672083 chr15:72433130 SENP8 -0.75 -16.73 -0.55 2.2e-52 Red blood cell count; BRCA cis rs11098499 0.739 rs2203039 chr4:120132347 T/C cg09307838 chr4:120376055 NA -0.49 -9.2 -0.34 5.14e-19 Corneal astigmatism; BRCA cis rs7917772 0.503 rs11191325 chr10:104302933 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs919433 0.680 rs6434930 chr2:198369370 A/G cg00792783 chr2:198669748 PLCL1 0.39 8.97 0.33 3.14e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1400816 0.850 rs3821096 chr2:172664020 C/T cg13550731 chr2:172543902 DYNC1I2 -0.54 -8.33 -0.31 4.99e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg19717773 chr7:2847554 GNA12 -0.43 -9.71 -0.36 7.11e-21 Height; BRCA cis rs7267979 0.934 rs4815423 chr20:25387521 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.63 -0.32 4.82e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2011503 1.000 rs6511029 chr19:19471419 G/T cg15839431 chr19:19639596 YJEFN3 0.4 8.84 0.33 9.43e-18 Bipolar disorder; BRCA trans rs208520 0.690 rs12209753 chr6:66703951 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 20.27 0.63 6.67e-71 Exhaled nitric oxide output; BRCA cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg18964960 chr10:1102726 WDR37 -0.51 -9.13 -0.34 8.55e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg05863683 chr7:1912471 MAD1L1 0.38 8.36 0.31 3.94e-16 Schizophrenia; BRCA cis rs4363385 0.510 rs7531076 chr1:153039167 G/T cg25856811 chr1:152973957 SPRR3 -0.31 -7.85 -0.3 1.8e-14 Inflammatory skin disease; BRCA cis rs2249625 0.545 rs2496505 chr6:72891063 C/G cg18830697 chr6:72922368 RIMS1 -0.64 -14.27 -0.49 2.63e-40 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs11098499 0.954 rs10008392 chr4:120318839 G/A cg09307838 chr4:120376055 NA 0.73 15.59 0.53 1.08e-46 Corneal astigmatism; BRCA cis rs6761276 0.649 rs3827763 chr2:113831289 C/T cg12858261 chr2:113808755 IL1F8 -0.43 -8.74 -0.33 2.08e-17 Protein quantitative trait loci; BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -14.4 -0.49 6.67e-41 Initial pursuit acceleration; BRCA cis rs13046373 0.535 rs2832964 chr21:32014012 A/C cg24082983 chr21:31802169 KRTAP13-4 0.32 8.16 0.31 1.83e-15 HDL cholesterol; BRCA cis rs10493773 0.532 rs12064199 chr1:86187073 A/T cg17807903 chr1:86174739 ZNHIT6 -0.59 -15.84 -0.53 6.88e-48 Urate levels in overweight individuals; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 11.66 0.42 1.3e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6089584 0.888 rs6061982 chr20:60620673 C/T cg13770153 chr20:60521292 NA -0.42 -9.45 -0.35 6.5e-20 Body mass index; BRCA cis rs9814567 0.806 rs4955525 chr3:134317008 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.39 -0.32 3.01e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10771431 0.782 rs10771415 chr12:9358223 C/T cg08997352 chr12:9597637 DDX12 -0.61 -12.41 -0.44 7.65e-32 Breast size; BRCA trans rs9325144 0.647 rs870431 chr12:38953073 T/C cg23762105 chr12:34175262 ALG10 0.35 8.11 0.31 2.55e-15 Morning vs. evening chronotype; BRCA cis rs6546550 0.743 rs6546548 chr2:70017022 A/G cg02498382 chr2:70120550 SNRNP27 -0.38 -7.99 -0.3 6.14e-15 Prevalent atrial fibrillation; BRCA cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg15017067 chr4:17643749 FAM184B 0.3 9.05 0.34 1.68e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1267303 0.716 rs942255 chr1:46989792 C/T cg25110126 chr1:46999211 NA 0.58 10.34 0.38 2.89e-23 Monobrow; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 20.0 0.62 1.89e-69 Platelet count; BRCA trans rs11098499 0.909 rs78332141 chr4:120375782 C/T cg25214090 chr10:38739885 LOC399744 0.55 12.47 0.44 4.27e-32 Corneal astigmatism; BRCA cis rs60871478 0.898 rs4725241 chr7:796883 C/T cg05535760 chr7:792225 HEATR2 0.73 13.44 0.47 2e-36 Cerebrospinal P-tau181p levels; BRCA cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg11764359 chr7:65958608 NA -0.76 -17.3 -0.56 2.89e-55 Aortic root size; BRCA cis rs9311474 0.629 rs9853056 chr3:52555957 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.27 8.81 0.33 1.15e-17 Electroencephalogram traits; BRCA cis rs9368481 0.546 rs12664610 chr6:26885031 G/A cg12292205 chr6:26970375 C6orf41 0.64 14.22 0.49 4.44e-40 Autism spectrum disorder or schizophrenia; BRCA cis rs13108904 0.775 rs2279282 chr4:1216033 G/C cg05665937 chr4:1216051 CTBP1 0.53 11.57 0.42 3.02e-28 Obesity-related traits; BRCA cis rs6570726 0.577 rs403345 chr6:145845171 T/C cg05347473 chr6:146136440 FBXO30 0.59 11.0 0.4 6.53e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs909002 0.849 rs6664789 chr1:32072406 C/G cg13919466 chr1:32135498 COL16A1 -0.25 -8.36 -0.31 3.9e-16 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.863 rs3775858 chr4:120486028 A/G cg25214090 chr10:38739885 LOC399744 0.5 11.47 0.41 7.99e-28 Corneal astigmatism; BRCA cis rs3733585 0.699 rs6844787 chr4:9959233 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12579753 1.000 rs12366580 chr12:82222784 G/A cg07988820 chr12:82153109 PPFIA2 -0.62 -10.1 -0.37 2.44e-22 Resting heart rate; BRCA cis rs17270561 0.609 rs9356985 chr6:25728098 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs6570726 0.791 rs446362 chr6:145878716 G/T cg05347473 chr6:146136440 FBXO30 0.43 8.57 0.32 7.57e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg22834771 chr12:69754056 YEATS4 -0.37 -9.16 -0.34 6.89e-19 Blood protein levels; BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.62 0.61 1.9e-67 Platelet count; BRCA cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg24562669 chr7:97807699 LMTK2 0.43 11.46 0.41 9.17e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg06917634 chr15:78832804 PSMA4 -0.75 -17.67 -0.57 3.59e-57 Sudden cardiac arrest; BRCA cis rs11971779 0.818 rs12056045 chr7:139025430 C/G cg07862535 chr7:139043722 LUC7L2 0.53 12.74 0.45 2.72e-33 Diisocyanate-induced asthma; BRCA cis rs4853036 0.857 rs1048139 chr2:70131791 T/A cg02498382 chr2:70120550 SNRNP27 -0.53 -9.59 -0.35 1.95e-20 Colorectal or endometrial cancer; BRCA trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg15704280 chr7:45808275 SEPT13 -0.52 -10.28 -0.38 4.8e-23 HDL cholesterol; BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg27170947 chr2:26402098 FAM59B 0.96 16.79 0.55 1.13e-52 Mean corpuscular hemoglobin; BRCA cis rs1577917 1.000 rs7756203 chr6:86627707 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA cis rs4722166 0.630 rs12537614 chr7:22789551 C/G cg26061582 chr7:22766209 IL6 0.42 9.5 0.35 4.25e-20 Lung cancer; BRCA cis rs6088813 1.000 rs6088815 chr20:33976474 G/C cg14752227 chr20:34000481 UQCC -0.39 -8.37 -0.31 3.73e-16 Height; BRCA cis rs1707322 0.717 rs10890345 chr1:46213927 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10193935 0.901 rs6713242 chr2:42470794 C/T cg27598129 chr2:42591480 NA -0.97 -13.27 -0.46 1.11e-35 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg24920358 chr1:40204285 PPIE -0.35 -8.17 -0.31 1.69e-15 Blood protein levels; BRCA cis rs1865760 0.623 rs12216125 chr6:25997458 C/T cg17691542 chr6:26056736 HIST1H1C 0.61 12.39 0.44 9.21e-32 Height; BRCA cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg08514558 chr10:81106712 PPIF 0.36 8.66 0.32 3.94e-17 Height; BRCA cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11890956 chr21:40555474 PSMG1 -0.63 -14.44 -0.5 4.01e-41 Menarche (age at onset); BRCA cis rs11971779 0.616 rs7784192 chr7:139039649 T/C cg07862535 chr7:139043722 LUC7L2 0.38 10.3 0.38 4.17e-23 Diisocyanate-induced asthma; BRCA cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg24110177 chr3:50126178 RBM5 -0.44 -9.59 -0.35 2.02e-20 Intelligence (multi-trait analysis); BRCA cis rs11608355 0.515 rs12826754 chr12:109923244 A/G cg05360138 chr12:110035743 NA 0.74 13.54 0.47 6.41e-37 Neuroticism; BRCA cis rs8072100 0.713 rs9807106 chr17:45457102 G/T cg08085267 chr17:45401833 C17orf57 -0.58 -11.87 -0.42 1.72e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11690935 0.959 rs7586207 chr2:172671094 A/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -29.11 -0.76 3.11e-119 Schizophrenia; BRCA cis rs208515 0.556 rs12201658 chr6:66678457 T/C cg07460842 chr6:66804631 NA 0.77 14.02 0.48 4.08e-39 Exhaled nitric oxide levels; BRCA cis rs58688157 0.705 rs7122021 chr11:595810 A/G cg16486109 chr11:613632 IRF7 0.42 8.83 0.33 1.01e-17 Systemic lupus erythematosus; BRCA cis rs6598955 0.671 rs7417505 chr1:26575523 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11644478 chr21:40555479 PSMG1 -0.5 -10.46 -0.38 1e-23 Menarche (age at onset); BRCA cis rs7593730 0.537 rs10803762 chr2:161105876 G/A cg22609984 chr2:161126801 NA 0.39 8.48 0.32 1.55e-16 Type 2 diabetes; BRCA cis rs875971 0.545 rs12673308 chr7:65631361 C/A cg11764359 chr7:65958608 NA 0.65 11.9 0.43 1.21e-29 Aortic root size; BRCA cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg10523679 chr1:76189770 ACADM 0.7 12.72 0.45 3.51e-33 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2108225 1.000 rs2108226 chr7:107453279 A/C cg18560240 chr7:107437656 SLC26A3 -0.49 -9.91 -0.36 1.25e-21 Ulcerative colitis; BRCA cis rs7123876 0.830 rs57614870 chr11:72435983 A/G cg04827223 chr11:72435913 ARAP1 -0.73 -18.35 -0.59 1.03e-60 Body mass index; BRCA cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg14926445 chr8:58193284 C8orf71 -0.46 -8.88 -0.33 6.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg23649088 chr2:200775458 C2orf69 0.63 10.95 0.4 1.08e-25 Schizophrenia; BRCA cis rs922692 0.744 rs2277545 chr15:79083591 T/C cg04896959 chr15:78267971 NA 0.37 8.65 0.32 4.25e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs10129255 0.500 rs1024350 chr14:107141122 C/T cg07958169 chr14:107095056 NA -0.37 -7.93 -0.3 9.52e-15 Kawasaki disease; BRCA cis rs2762353 0.718 rs1184804 chr6:25868226 T/C cg03517284 chr6:25882590 NA -0.52 -12.05 -0.43 2.95e-30 Blood metabolite levels; BRCA trans rs877282 0.842 rs35117541 chr10:764683 C/T cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs4363385 0.765 rs1094409 chr1:153021040 T/A cg24667326 chr1:152973720 SPRR3 -0.31 -8.42 -0.32 2.54e-16 Inflammatory skin disease; BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg05863683 chr7:1912471 MAD1L1 0.4 8.58 0.32 7e-17 Bipolar disorder and schizophrenia; BRCA cis rs7091068 0.522 rs10882323 chr10:95483280 T/C cg20715218 chr10:95462985 C10orf4 0.48 9.13 0.34 8.67e-19 Urinary tract infection frequency; BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 16.41 0.54 9.01e-51 Platelet count; BRCA cis rs2304206 0.614 rs12104272 chr19:50148052 A/G cg09250473 chr19:50168907 IRF3;BCL2L12 -0.6 -11.68 -0.42 1.02e-28 Vitiligo; BRCA cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA cis rs858239 0.600 rs6967419 chr7:23136310 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.89 0.43 1.36e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs4363385 0.693 rs4845331 chr1:152982623 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.15e-18 Inflammatory skin disease; BRCA trans rs208520 0.955 rs17644076 chr6:67004973 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.84 -14.16 -0.49 8.49e-40 Exhaled nitric oxide output; BRCA cis rs826838 0.709 rs4882355 chr12:38721462 A/T cg26384229 chr12:38710491 ALG10B 0.51 12.78 0.45 1.76e-33 Heart rate; BRCA cis rs4423214 0.625 rs78685409 chr11:71137383 T/C cg05163923 chr11:71159392 DHCR7 -0.56 -11.19 -0.4 1.1e-26 Vitamin D levels; BRCA cis rs3820928 0.845 rs13415319 chr2:227878936 G/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.78 -0.33 1.54e-17 Pulmonary function; BRCA cis rs10924970 0.934 rs2891026 chr1:235429907 A/C cg26050004 chr1:235667680 B3GALNT2 0.33 8.14 0.31 2.08e-15 Asthma; BRCA cis rs35110281 0.712 rs8133523 chr21:45062403 A/G cg21573476 chr21:45109991 RRP1B -0.35 -8.92 -0.33 4.7e-18 Mean corpuscular volume; BRCA cis rs4689388 0.890 rs1801206 chr4:6302707 C/T cg00701064 chr4:6280414 WFS1 0.67 18.42 0.59 4.34e-61 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1843834 0.505 rs2140508 chr2:225355839 G/T cg22509189 chr2:225307070 NA -0.46 -9.89 -0.36 1.5e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs10493773 1.000 rs2274738 chr1:86119898 A/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.15 -0.34 7.77e-19 Urate levels in overweight individuals; BRCA cis rs4481887 0.927 rs4336885 chr1:248473168 A/C cg00666640 chr1:248458726 OR2T12 0.32 8.76 0.33 1.73e-17 Common traits (Other); BRCA trans rs61931739 0.500 rs7310237 chr12:34483435 G/A cg26384229 chr12:38710491 ALG10B 0.58 13.39 0.47 3.38e-36 Morning vs. evening chronotype; BRCA cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.55 12.26 0.44 3.34e-31 Colorectal cancer; BRCA cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg13271783 chr10:134563150 INPP5A -0.49 -10.03 -0.37 4.42e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg25358565 chr5:93447407 FAM172A -1.15 -18.02 -0.58 5.22e-59 Diabetic retinopathy; BRCA cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg20476274 chr7:133979776 SLC35B4 0.55 13.31 0.47 7.47e-36 Mean platelet volume; BRCA cis rs8114671 0.562 rs6088636 chr20:33469746 C/T cg07148914 chr20:33460835 GGT7 0.37 8.41 0.32 2.59e-16 Height; BRCA cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs11758351 0.715 rs76130408 chr6:26208962 A/G cg01420254 chr6:26195488 NA 0.55 8.51 0.32 1.23e-16 Gout;Renal underexcretion gout; BRCA cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg10295955 chr4:187884368 NA -0.96 -28.43 -0.75 1.47e-115 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg22907277 chr7:1156413 C7orf50 0.51 11.16 0.4 1.51e-26 Longevity;Endometriosis; BRCA cis rs16958440 0.867 rs74845165 chr18:44690852 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs7666738 0.830 rs34892904 chr4:98938097 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs910316 0.763 rs735452 chr14:75497984 A/G cg23033748 chr14:75592666 NEK9 -0.36 -8.43 -0.32 2.36e-16 Height; BRCA cis rs738322 1.000 rs738320 chr22:38568715 G/T cg25457927 chr22:38595422 NA -0.31 -11.75 -0.42 5.26e-29 Cutaneous nevi; BRCA trans rs7824557 0.507 rs7010590 chr8:11062882 C/T cg08975724 chr8:8085496 FLJ10661 0.39 8.1 0.31 2.87e-15 Retinal vascular caliber; BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg09877947 chr5:131593287 PDLIM4 0.4 10.15 0.37 1.5e-22 Breast cancer; BRCA cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg16339924 chr4:17578868 LAP3 0.71 16.83 0.55 6.93e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3917254 0.543 rs12470623 chr2:102744015 A/T cg22835712 chr2:102737379 NA -0.53 -9.33 -0.35 1.72e-19 Blood protein levels; BRCA cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.75 -0.53 1.79e-47 Chronic sinus infection; BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg01262667 chr19:19385393 TM6SF2 0.42 10.97 0.4 9.28e-26 Tonsillectomy; BRCA cis rs1577917 1.000 rs12215037 chr6:86727631 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.54 -13.89 -0.48 1.61e-38 Response to antipsychotic treatment; BRCA trans rs116095464 0.558 rs56298907 chr5:283280 C/A cg00938859 chr5:1591904 SDHAP3 0.69 9.4 0.35 9.53e-20 Breast cancer; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg11905131 chr22:24372483 LOC391322 0.57 12.89 0.45 6.06e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6539267 0.847 rs17217845 chr12:106697802 C/T cg00173435 chr12:106696525 TCP11L2 -0.54 -8.12 -0.31 2.4e-15 Tourette syndrome; BRCA cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg06108461 chr20:60628389 TAF4 -1.01 -22.22 -0.66 1.81e-81 Body mass index; BRCA trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg15704280 chr7:45808275 SEPT13 0.73 15.2 0.52 9.16e-45 Height; BRCA trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg15704280 chr7:45808275 SEPT13 0.7 14.4 0.49 6.33e-41 Coronary artery disease; BRCA cis rs965469 0.779 rs6051785 chr20:3339199 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.85 -0.33 8.26e-18 IFN-related cytopenia; BRCA cis rs9325144 0.560 rs10506127 chr12:39126686 C/G cg26384229 chr12:38710491 ALG10B -0.49 -12.4 -0.44 8.84e-32 Morning vs. evening chronotype; BRCA cis rs3733585 0.673 rs6850143 chr4:9958924 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg06970220 chr1:156163860 SLC25A44 0.38 9.1 0.34 1.17e-18 Testicular germ cell tumor; BRCA cis rs9341808 0.718 rs10943699 chr6:80940541 G/A cg08355045 chr6:80787529 NA 0.39 9.94 0.37 9.33e-22 Sitting height ratio; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.79 -14.38 -0.49 7.94e-41 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11252926 0.537 rs61836851 chr10:447231 T/C cg18196295 chr10:418757 DIP2C 0.49 11.82 0.42 2.79e-29 Psychosis in Alzheimer's disease; BRCA cis rs10463316 0.784 rs906678 chr5:150779040 T/C cg03212797 chr5:150827313 SLC36A1 -0.39 -7.83 -0.3 2.09e-14 Metabolite levels (Pyroglutamine); BRCA cis rs11191270 0.554 rs11191253 chr10:104066507 A/T cg15320455 chr10:103880129 LDB1 0.73 10.7 0.39 1.05e-24 Intelligence (multi-trait analysis); BRCA cis rs7639513 0.767 rs9861271 chr3:12707620 A/C cg23032965 chr3:12705835 RAF1 0.7 15.4 0.52 1e-45 Itch intensity from mosquito bite; BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg00166722 chr3:10149974 C3orf24 0.64 11.17 0.4 1.42e-26 Alzheimer's disease; BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg00106254 chr7:1943704 MAD1L1 -0.46 -12.41 -0.44 7.79e-32 Bipolar disorder and schizophrenia; BRCA cis rs10751667 0.621 rs7396049 chr11:1001561 G/A cg06064525 chr11:970664 AP2A2 -0.27 -8.02 -0.3 4.98e-15 Alzheimer's disease (late onset); BRCA cis rs7447593 0.666 rs10866705 chr5:176801131 G/T cg17509989 chr5:176798049 RGS14 -0.8 -15.76 -0.53 1.61e-47 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs80130819 0.515 rs1793915 chr12:48386577 G/T cg05342945 chr12:48394962 COL2A1 -0.48 -9.53 -0.35 3.12e-20 Prostate cancer; BRCA cis rs2806561 0.704 rs2806570 chr1:23527005 C/T cg19743168 chr1:23544995 NA -0.34 -8.08 -0.3 3.17e-15 Height; BRCA cis rs2880765 0.835 rs4842887 chr15:86035810 T/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.51 -0.32 1.21e-16 Coronary artery disease; BRCA cis rs9287719 0.649 rs12476554 chr2:10727747 A/G cg00105475 chr2:10696890 NA 0.41 9.18 0.34 5.83e-19 Prostate cancer; BRCA cis rs2832191 0.633 rs2832166 chr21:30462395 G/C cg08807101 chr21:30365312 RNF160 0.74 18.8 0.6 4.35e-63 Dental caries; BRCA cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg06544989 chr22:39130855 UNC84B -0.39 -10.08 -0.37 2.85e-22 Menopause (age at onset); BRCA cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg15017067 chr4:17643749 FAM184B -0.28 -8.21 -0.31 1.25e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1997103 1.000 rs10270618 chr7:55396712 T/A cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs637571 0.522 rs538954 chr11:65756808 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.61 13.59 0.47 4.07e-37 Eosinophil percentage of white cells; BRCA trans rs526821 0.553 rs510095 chr11:55289154 T/C cg15704280 chr7:45808275 SEPT13 -0.42 -7.89 -0.3 1.35e-14 Pediatric bone mineral density (spine); BRCA trans rs7980799 0.649 rs2084391 chr12:33655419 C/T cg26384229 chr12:38710491 ALG10B -0.44 -9.62 -0.36 1.48e-20 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs11764590 0.950 rs55683212 chr7:2078855 G/C cg02743256 chr7:2109353 MAD1L1 -0.44 -8.25 -0.31 8.98e-16 Neuroticism; BRCA cis rs6121246 0.609 rs6089075 chr20:30392884 A/G cg21427119 chr20:30132790 HM13 -0.35 -7.92 -0.3 1.09e-14 Mean corpuscular hemoglobin; BRCA cis rs875971 0.895 rs1974769 chr7:65950614 G/A cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA trans rs4718428 0.705 rs4718422 chr7:66359269 A/G cg18876405 chr7:65276391 NA 0.43 8.39 0.32 3.04e-16 Corneal structure; BRCA cis rs875971 0.660 rs10950044 chr7:66042976 A/G cg11764359 chr7:65958608 NA -0.68 -15.38 -0.52 1.14e-45 Aortic root size; BRCA cis rs2652822 0.967 rs4775633 chr15:63437746 G/A cg02713581 chr15:63449717 RPS27L 0.49 9.89 0.36 1.45e-21 Metabolic traits; BRCA cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg03146154 chr1:46216737 IPP 0.45 9.72 0.36 6.45e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.53 0.44 2.37e-32 Platelet count; BRCA cis rs10492096 1.000 rs11064210 chr12:6576721 C/T cg13857086 chr12:6580257 VAMP1 0.42 8.08 0.3 3.18e-15 Hip geometry; BRCA cis rs3008870 1.000 rs2985818 chr1:67398916 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.99 22.65 0.67 8.12e-84 Lymphocyte percentage of white cells; BRCA trans rs9467711 0.606 rs9358939 chr6:26416787 C/G cg01620082 chr3:125678407 NA -0.62 -8.23 -0.31 1.08e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs13064411 0.542 rs9874747 chr3:113221258 G/A cg18753928 chr3:113234510 CCDC52 -0.47 -10.11 -0.37 2.15e-22 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg00012203 chr2:219082015 ARPC2 -0.48 -9.32 -0.35 1.92e-19 Colorectal cancer; BRCA cis rs694739 0.930 rs574087 chr11:64102948 A/G cg02228329 chr11:64053129 BAD;GPR137 0.53 11.17 0.4 1.44e-26 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg11663144 chr21:46675770 NA -0.64 -15.28 -0.52 3.72e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2153535 0.542 rs915354 chr6:8440357 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.29 0.38 4.28e-23 Motion sickness; BRCA cis rs17376456 0.877 rs28633397 chr5:93447048 A/G cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 8.21 0.31 1.22e-15 Diabetic retinopathy; BRCA cis rs7267979 1.000 rs6115146 chr20:25304507 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.6 -0.35 1.84e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg13628971 chr7:2884303 GNA12 0.44 8.74 0.33 2.03e-17 Height; BRCA trans rs11098499 0.863 rs3822195 chr4:120471660 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg24879335 chr3:133465180 TF 0.33 11.07 0.4 3.67e-26 Iron status biomarkers (transferrin levels); BRCA cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg11833968 chr6:79620685 NA -0.43 -9.8 -0.36 3.26e-21 Intelligence (multi-trait analysis); BRCA cis rs17023223 0.537 rs12097967 chr1:119702913 A/G cg05756136 chr1:119680316 WARS2 -0.42 -7.99 -0.3 6.09e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.41 0.5 5.45e-41 Motion sickness; BRCA cis rs56104184 0.725 rs1466896 chr19:49385253 C/G cg21252483 chr19:49399788 TULP2 -0.5 -10.99 -0.4 7.77e-26 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs56804039 1.000 rs6986470 chr8:8381430 A/G cg06636001 chr8:8085503 FLJ10661 -0.56 -9.29 -0.35 2.32e-19 Cervical cancer; BRCA cis rs7613875 0.580 rs11709503 chr3:49991167 G/T cg05623727 chr3:50126028 RBM5 0.49 11.81 0.42 3.01e-29 Body mass index; BRCA cis rs72781680 0.898 rs72796152 chr2:23933626 G/A cg20701182 chr2:24300061 SF3B14 0.55 8.19 0.31 1.38e-15 Lymphocyte counts; BRCA cis rs6005807 0.640 rs7289534 chr22:29016057 C/T cg12565055 chr22:29076175 TTC28 0.49 9.33 0.35 1.65e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs7666738 0.830 rs10009943 chr4:99021475 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.865 rs4001305 chr4:120359236 G/T cg25214090 chr10:38739885 LOC399744 0.54 12.5 0.44 3.02e-32 Corneal astigmatism; BRCA trans rs2204008 0.715 rs12368462 chr12:38336116 C/G cg06521331 chr12:34319734 NA -0.48 -8.72 -0.33 2.44e-17 Bladder cancer; BRCA cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10465746 0.746 rs6699501 chr1:84389993 A/G cg10977910 chr1:84465055 TTLL7 0.58 12.06 0.43 2.56e-30 Obesity-related traits; BRCA cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs7246657 0.943 rs10405325 chr19:37883477 G/C cg18154014 chr19:37997991 ZNF793 0.62 11.73 0.42 6.45e-29 Coronary artery calcification; BRCA trans rs11775334 0.599 rs11774836 chr8:10062543 A/G cg06636001 chr8:8085503 FLJ10661 -0.42 -8.32 -0.31 5.41e-16 Hypertension; BRCA cis rs6545883 0.860 rs6749226 chr2:61509783 G/A cg15711740 chr2:61764176 XPO1 0.49 12.08 0.43 2.07e-30 Tuberculosis; BRCA cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg09184832 chr6:79620586 NA -0.53 -11.71 -0.42 7.74e-29 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.666 rs7394427 chr11:970405 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.36 8.14 0.31 2.08e-15 Tonsillectomy; BRCA cis rs3820928 0.874 rs4234062 chr2:227819050 C/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.88 -0.33 6.91e-18 Pulmonary function; BRCA cis rs9527 0.615 rs7073295 chr10:104672233 A/G cg04362960 chr10:104952993 NT5C2 0.45 10.36 0.38 2.38e-23 Arsenic metabolism; BRCA cis rs1577917 0.958 rs10944168 chr6:86680156 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -13.41 -0.47 2.55e-36 Response to antipsychotic treatment; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.7 -0.59 1.36e-62 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs870825 0.860 rs2705899 chr4:185596219 A/G cg04058563 chr4:185651563 MLF1IP 0.67 11.95 0.43 7.77e-30 Blood protein levels; BRCA cis rs2066819 1.000 rs74496027 chr12:56726340 C/T cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg15017067 chr4:17643749 FAM184B 0.29 8.38 0.31 3.28e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9325144 0.555 rs1973292 chr12:38679626 T/C cg13010199 chr12:38710504 ALG10B 0.35 8.26 0.31 8.26e-16 Morning vs. evening chronotype; BRCA cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg02079420 chr8:82753780 SNX16 -0.31 -8.53 -0.32 1.09e-16 Diastolic blood pressure; BRCA cis rs881375 1.000 rs1609810 chr9:123642351 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.68 0.32 3.25e-17 Rheumatoid arthritis; BRCA cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.56 -11.48 -0.41 7.48e-28 Personality dimensions; BRCA cis rs561341 1.000 rs497479 chr17:30328605 C/T cg23018236 chr17:30244563 NA -0.64 -10.31 -0.38 3.67e-23 Hip circumference adjusted for BMI; BRCA cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg16384552 chr7:74938386 SPDYE8P 0.45 9.56 0.35 2.53e-20 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg12311346 chr5:56204834 C5orf35 -0.81 -16.05 -0.54 5.76e-49 Initial pursuit acceleration; BRCA cis rs4319547 0.619 rs7973869 chr12:122874284 G/C cg23029597 chr12:123009494 RSRC2 -0.56 -11.26 -0.41 5.89e-27 Body mass index; BRCA cis rs250677 0.524 rs250665 chr5:148454394 A/C cg18129178 chr5:148520854 ABLIM3 -0.49 -10.53 -0.38 5.1e-24 Breast cancer; BRCA cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.48 0.44 3.94e-32 Electroencephalogram traits; BRCA trans rs11976180 1.000 rs1320893 chr7:143752112 A/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.82 -0.33 1.08e-17 Obesity-related traits; BRCA cis rs11605924 0.935 rs6485645 chr11:45862353 A/G ch.11.939596F chr11:45881766 CRY2 -0.46 -9.97 -0.37 7.15e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg05623727 chr3:50126028 RBM5 -0.42 -9.98 -0.37 7e-22 Intelligence (multi-trait analysis); BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg04166393 chr7:2884313 GNA12 0.51 10.03 0.37 4.2e-22 Height; BRCA cis rs3772130 0.961 rs1573819 chr3:121469646 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.61 0.36 1.58e-20 Cognitive performance; BRCA trans rs35110281 0.591 rs162366 chr21:44935383 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.44 -9.31 -0.35 2.07e-19 Mean corpuscular volume; BRCA cis rs7833790 0.724 rs6473311 chr8:82726682 G/A cg17211192 chr8:82754475 SNX16 -0.52 -11.94 -0.43 8.29e-30 Diastolic blood pressure; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg16590910 chr6:42928470 GNMT 0.37 8.11 0.31 2.58e-15 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs877282 1.000 rs12763443 chr10:771941 G/A cg17470449 chr10:769945 NA 0.53 9.27 0.34 2.81e-19 Uric acid levels; BRCA cis rs7582180 0.629 rs11686880 chr2:100956229 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.96 -0.3 8.07e-15 Intelligence (multi-trait analysis); BRCA cis rs881375 0.933 rs7031096 chr9:123694942 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.48 0.32 1.53e-16 Rheumatoid arthritis; BRCA cis rs4478858 0.698 rs6669381 chr1:31833506 A/G cg00250761 chr1:31883323 NA -0.33 -8.45 -0.32 2.03e-16 Alcohol dependence; BRCA cis rs10267417 0.603 rs10229973 chr7:19894778 G/A cg07541023 chr7:19748670 TWISTNB 0.46 8.32 0.31 5.3e-16 Night sleep phenotypes; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg16145915 chr7:1198662 ZFAND2A -0.42 -10.14 -0.37 1.6400000000000001e-22 Longevity;Endometriosis; BRCA cis rs6430585 0.941 rs10496737 chr2:136540083 A/G cg07169764 chr2:136633963 MCM6 1.0 20.29 0.63 4.98e-71 Corneal structure; BRCA cis rs2637266 0.935 rs7477361 chr10:78393586 G/A cg18941641 chr10:78392320 NA 0.35 8.0 0.3 5.69e-15 Pulmonary function; BRCA cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg15412446 chr2:106886593 NA -0.53 -9.33 -0.35 1.73e-19 Facial morphology (factor 23); BRCA cis rs4718428 0.607 rs66954441 chr7:66369209 T/C cg18252515 chr7:66147081 NA -0.54 -10.94 -0.4 1.15e-25 Corneal structure; BRCA cis rs35661897 0.920 rs12478549 chr2:227329662 T/A cg03426602 chr2:227312417 NA -0.51 -8.28 -0.31 7.12e-16 Urinary tract infection frequency; BRCA cis rs17345786 0.906 rs59359251 chr3:101146362 A/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 9.12 0.34 9.79e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.713 rs12366709 chr12:38210179 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg05084668 chr3:125655381 ALG1L -0.47 -8.09 -0.3 2.91e-15 Blood pressure (smoking interaction); BRCA cis rs877529 0.625 rs714016 chr22:39532554 G/T cg12193277 chr22:39547181 CBX7 -0.36 -8.42 -0.32 2.56e-16 Multiple myeloma; BRCA cis rs12824058 0.831 rs7310433 chr12:130809289 C/T cg26677194 chr12:130822605 PIWIL1 0.6 14.33 0.49 1.31e-40 Menopause (age at onset); BRCA cis rs13046373 0.508 rs13048637 chr21:31999055 T/G cg14062083 chr21:31802829 KRTAP13-4 0.34 9.17 0.34 6.55e-19 HDL cholesterol; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg23978390 chr7:1156363 C7orf50 0.39 9.26 0.34 3.01e-19 Longevity;Endometriosis; BRCA cis rs7264396 0.733 rs6058305 chr20:34310757 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -16.19 -0.54 1.18e-49 Total cholesterol levels; BRCA trans rs7939886 0.920 rs7940563 chr11:55875133 C/T cg15704280 chr7:45808275 SEPT13 0.61 7.93 0.3 1.01e-14 Myopia (pathological); BRCA cis rs6840360 0.571 rs72730104 chr4:152543857 A/G cg22705602 chr4:152727874 NA -0.32 -8.05 -0.3 3.95e-15 Intelligence (multi-trait analysis); BRCA cis rs367943 1.000 rs348957 chr5:112821178 C/T cg12552261 chr5:112820674 MCC 0.55 12.1 0.43 1.66e-30 Type 2 diabetes; BRCA cis rs16858210 0.607 rs59321941 chr3:183571024 A/G cg25686905 chr3:183603175 PARL -0.4 -8.56 -0.32 8.57e-17 Menopause (age at onset); BRCA cis rs6484504 0.576 rs11031324 chr11:31250299 T/C cg06552810 chr11:31128660 NA -0.4 -8.88 -0.33 6.83e-18 Red blood cell count; BRCA cis rs7552404 0.731 rs11588578 chr1:76400539 T/G cg10523679 chr1:76189770 ACADM 0.6 10.6 0.39 2.79e-24 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg17971929 chr21:40555470 PSMG1 -0.62 -13.88 -0.48 1.73e-38 Cognitive function; BRCA cis rs2836974 0.831 rs2836921 chr21:40516070 C/T cg17971929 chr21:40555470 PSMG1 0.71 14.7 0.5 2.31e-42 Cognitive function; BRCA cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg26031613 chr14:104095156 KLC1 -0.54 -9.77 -0.36 3.99e-21 Reticulocyte count; BRCA trans rs7178375 1.000 rs7178533 chr15:31215976 C/G cg04373760 chr16:53404718 NA 0.46 8.5 0.32 1.29e-16 Hypertriglyceridemia; BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg09877947 chr5:131593287 PDLIM4 0.47 11.5 0.41 6.11e-28 Acylcarnitine levels; BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg11814155 chr7:99998594 ZCWPW1 0.42 7.95 0.3 8.26e-15 Platelet count; BRCA trans rs35110281 0.686 rs162399 chr21:44950020 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.16 0.37 1.43e-22 Mean corpuscular volume; BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.47 7.84 0.3 1.9e-14 Renal function-related traits (BUN); BRCA cis rs9790314 0.613 rs13086250 chr3:160631965 G/A cg03342759 chr3:160939853 NMD3 0.44 8.8 0.33 1.25e-17 Morning vs. evening chronotype; BRCA cis rs6546550 0.904 rs3771537 chr2:70038792 A/C cg02498382 chr2:70120550 SNRNP27 -0.4 -8.64 -0.32 4.62e-17 Prevalent atrial fibrillation; BRCA cis rs2387326 0.680 rs954650 chr10:129941513 C/A cg16087940 chr10:129947807 NA -0.46 -7.99 -0.3 6.51e-15 Select biomarker traits; BRCA cis rs2153535 0.601 rs7741024 chr6:8530313 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.11e-40 Motion sickness; BRCA cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 9.19e-19 Bipolar disorder; BRCA cis rs7086627 0.515 rs10887900 chr10:82210265 A/G cg00277334 chr10:82204260 NA -0.84 -23.85 -0.69 2e-90 Post bronchodilator FEV1; BRCA cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg14558114 chr2:88469736 THNSL2 -0.41 -9.08 -0.34 1.39e-18 Response to metformin (IC50); BRCA cis rs752010 0.756 rs943374 chr1:42056194 A/G cg06885757 chr1:42089581 HIVEP3 0.23 8.42 0.32 2.41e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2204008 0.837 rs12369089 chr12:38060263 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.25e-54 Bladder cancer; BRCA trans rs1005277 0.579 rs1780116 chr10:38526621 C/T cg23533926 chr12:111358616 MYL2 -0.43 -8.95 -0.33 3.88e-18 Extrinsic epigenetic age acceleration; BRCA cis rs881375 0.715 rs10818482 chr9:123648085 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 -0.49 -10.94 -0.4 1.22e-25 Rheumatoid arthritis; BRCA cis rs9368481 0.524 rs9393768 chr6:26885619 A/G cg18867708 chr6:26865862 GUSBL1 0.42 8.36 0.31 4.03e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg16145915 chr7:1198662 ZFAND2A -0.55 -12.96 -0.46 2.77e-34 Longevity;Endometriosis; BRCA cis rs801193 1.000 rs2659912 chr7:66157999 G/C cg11764359 chr7:65958608 NA 0.67 15.14 0.51 1.7e-44 Aortic root size; BRCA cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg02269571 chr22:50332266 NA 0.53 7.92 0.3 1.09e-14 Schizophrenia; BRCA cis rs2797160 0.875 rs12527010 chr6:125991507 A/G cg05901451 chr6:126070800 HEY2 0.46 11.53 0.41 4.7e-28 Endometrial cancer; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg14863265 chr7:2801509 GNA12 -0.5 -10.78 -0.39 5.22e-25 Height; BRCA cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg06713675 chr4:122721982 EXOSC9 -0.54 -12.58 -0.45 1.41e-32 Type 2 diabetes; BRCA cis rs9814567 0.964 rs9820150 chr3:134223011 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.41 -0.32 2.73e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2839186 0.934 rs2839194 chr21:47699437 T/G cg12379764 chr21:47803548 PCNT -0.38 -8.1 -0.31 2.86e-15 Testicular germ cell tumor; BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.6 -0.45 1.15e-32 Alzheimer's disease; BRCA cis rs1865760 1.000 rs3752421 chr6:25918688 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 11.42 0.41 1.27e-27 Height; BRCA cis rs6942756 0.956 rs7792317 chr7:128963971 G/A cg02491457 chr7:128862824 NA -0.71 -14.09 -0.49 1.8e-39 White matter hyperintensity burden; BRCA cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg00074818 chr8:8560427 CLDN23 0.37 8.16 0.31 1.77e-15 Obesity-related traits; BRCA cis rs1570989 0.571 rs6916066 chr6:12016009 G/C cg17804551 chr6:12015979 HIVEP1 0.41 9.9 0.36 1.32e-21 Alcohol and nicotine co-dependence; BRCA cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg06064525 chr11:970664 AP2A2 -0.5 -17.02 -0.56 7.5e-54 Alzheimer's disease (late onset); BRCA trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg04450456 chr4:17643702 FAM184B -0.32 -9.11 -0.34 1.09e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4819052 0.851 rs10470247 chr21:46659018 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 12.86 0.45 8.26e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11677370 0.574 rs11686118 chr2:3854938 C/T cg17052675 chr2:3827356 NA -0.51 -11.96 -0.43 6.77e-30 Type 2 diabetes; BRCA cis rs7493 0.853 rs35686517 chr7:95052611 G/A cg17330251 chr7:94953956 PON1 -0.42 -8.64 -0.32 4.63e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs6479891 1.000 rs12413730 chr10:64964148 C/T cg14819942 chr15:35414228 NA 0.35 8.65 0.32 4.26e-17 Arthritis (juvenile idiopathic); BRCA cis rs3806843 0.735 rs801189 chr5:140063091 A/G cg26395211 chr5:140044315 WDR55 0.37 8.6 0.32 6e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs9640161 0.750 rs11769348 chr7:150026753 C/T cg12556325 chr7:150026731 C7orf29;LRRC61 0.59 14.24 0.49 3.79e-40 Blood protein levels;Circulating chemerin levels; BRCA cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg25319279 chr11:5960081 NA 0.42 8.2 0.31 1.35e-15 DNA methylation (variation); BRCA cis rs6700896 0.931 rs2154384 chr1:66108517 C/T cg04111102 chr1:66153794 NA 0.34 8.41 0.32 2.71e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs911119 0.913 rs13037490 chr20:23583725 T/C cg16589663 chr20:23618590 CST3 0.46 8.28 0.31 7.17e-16 Chronic kidney disease; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg14004847 chr7:1930337 MAD1L1 -0.43 -8.77 -0.33 1.66e-17 Bipolar disorder and schizophrenia; BRCA cis rs68170813 0.559 rs60255281 chr7:106963913 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.92 -0.33 5.05e-18 Coronary artery disease; BRCA trans rs4718428 0.960 rs6460317 chr7:66390255 A/G cg18876405 chr7:65276391 NA 0.45 10.02 0.37 4.6e-22 Corneal structure; BRCA cis rs4862750 0.872 rs6553030 chr4:187899234 T/C cg22105103 chr4:187893119 NA 0.41 13.39 0.47 3.27e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs1401999 0.864 rs4148563 chr3:183725999 T/C cg01324343 chr3:183735012 ABCC5 0.8 20.01 0.62 1.52e-69 Anterior chamber depth; BRCA cis rs243505 0.559 rs734003 chr7:148505498 T/G cg09806900 chr7:148480153 CUL1 0.53 10.94 0.4 1.2e-25 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11190604 1.000 rs2495753 chr10:102325640 C/T cg07080220 chr10:102295463 HIF1AN 0.62 13.38 0.47 3.49e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg18402987 chr7:1209562 NA 0.42 7.97 0.3 7.26e-15 Longevity;Endometriosis; BRCA cis rs1997103 0.954 rs940880 chr7:55392619 C/G cg17469321 chr7:55412551 NA 0.51 9.76 0.36 4.44e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2066819 1.000 rs75265219 chr12:56640341 G/A cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs9487051 0.621 rs351726 chr6:109548304 C/T cg01475377 chr6:109611718 NA -0.39 -7.84 -0.3 1.9e-14 Reticulocyte fraction of red cells; BRCA cis rs56159542 1 rs56159542 chr19:19682971 T/C cg11584989 chr19:19387371 SF4 -0.48 -9.77 -0.36 4.24e-21 Attention deficit hyperactivity disorder symptom score; BRCA cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.81 11.72 0.42 6.92e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg06640241 chr16:89574553 SPG7 0.87 22.42 0.66 1.46e-82 Multiple myeloma (IgH translocation); BRCA cis rs56011263 0.687 rs4690293 chr4:706101 A/G cg20735989 chr4:730612 PCGF3 -0.4 -8.91 -0.33 5.29e-18 White blood cell count; BRCA trans rs61931739 0.890 rs694706 chr12:34135323 T/C cg26384229 chr12:38710491 ALG10B 0.44 10.57 0.39 3.48e-24 Morning vs. evening chronotype; BRCA trans rs1005277 0.563 rs2505216 chr10:38482830 T/C cg23533926 chr12:111358616 MYL2 -0.43 -9.0 -0.34 2.62e-18 Extrinsic epigenetic age acceleration; BRCA cis rs7737355 0.947 rs40400 chr5:130831365 C/T cg06307176 chr5:131281290 NA -0.52 -10.5 -0.38 6.84e-24 Life satisfaction; BRCA cis rs2153535 0.541 rs6905934 chr6:8440043 C/A cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.02e-40 Motion sickness; BRCA cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg12311346 chr5:56204834 C5orf35 -0.82 -16.25 -0.54 5.79e-50 Initial pursuit acceleration; BRCA cis rs12586317 0.508 rs10134914 chr14:35425012 T/G cg16230307 chr14:35515116 FAM177A1 0.62 13.87 0.48 1.94e-38 Psoriasis; BRCA cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg13880726 chr7:1868755 MAD1L1 0.39 8.01 0.3 5.64e-15 Bipolar disorder and schizophrenia; BRCA cis rs1843834 0.755 rs10197382 chr2:225574650 T/C cg22455342 chr2:225449267 CUL3 0.34 8.11 0.31 2.67e-15 IgE levels in asthmatics (D.p. specific); BRCA cis rs6963495 0.818 rs6977748 chr7:105167462 T/G cg19920283 chr7:105172520 RINT1 0.57 8.99 0.34 2.79e-18 Bipolar disorder (body mass index interaction); BRCA cis rs8180040 0.620 rs9845728 chr3:47103376 C/T cg27129171 chr3:47204927 SETD2 0.71 17.18 0.56 1.13e-54 Colorectal cancer; BRCA cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg24578937 chr1:2090814 PRKCZ 0.35 10.73 0.39 8.57e-25 Height; BRCA cis rs17376456 0.825 rs12716454 chr5:93272279 A/C cg25358565 chr5:93447407 FAM172A 1.22 18.72 0.6 1.12e-62 Diabetic retinopathy; BRCA cis rs1401999 0.807 rs9869029 chr3:183735286 C/G cg01324343 chr3:183735012 ABCC5 0.86 21.62 0.65 3.05e-78 Anterior chamber depth; BRCA cis rs6570726 0.935 rs425717 chr6:145838620 A/T cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs68170813 0.559 rs1548523 chr7:106944408 G/A cg02696742 chr7:106810147 HBP1 -0.52 -8.51 -0.32 1.23e-16 Coronary artery disease; BRCA trans rs61931739 0.500 rs12367292 chr12:33998075 T/C cg26384229 chr12:38710491 ALG10B 0.66 13.84 0.48 2.82e-38 Morning vs. evening chronotype; BRCA cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.49 0.38 7.33e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs7560272 0.501 rs10191988 chr2:73947787 A/G cg20560298 chr2:73613845 ALMS1 0.33 8.32 0.31 5.25e-16 Schizophrenia; BRCA cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg17120908 chr11:65337727 SSSCA1 0.53 9.74 0.36 5.51e-21 Bone mineral density; BRCA cis rs1865721 0.771 rs7235563 chr18:73139335 C/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.74 -0.39 7.34e-25 Intelligence; BRCA cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg13877915 chr19:58951672 ZNF132 0.46 10.88 0.4 2.08e-25 Uric acid clearance; BRCA cis rs2832077 1.000 rs2832065 chr21:30135362 C/T cg24692254 chr21:30365293 RNF160 -0.46 -8.13 -0.31 2.31e-15 Cognitive test performance; BRCA cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg12310025 chr6:25882481 NA -0.54 -11.75 -0.42 5.2e-29 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg02951883 chr7:2050386 MAD1L1 -0.51 -11.1 -0.4 2.63e-26 Bipolar disorder and schizophrenia; BRCA cis rs72928364 0.860 rs34281790 chr3:100790767 G/A cg10123952 chr3:100791384 NA 0.59 8.51 0.32 1.2e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2180341 0.960 rs1543432 chr6:127698018 T/C cg27446573 chr6:127587934 RNF146 0.89 20.42 0.63 1e-71 Breast cancer; BRCA cis rs2625529 0.824 rs7183749 chr15:72377278 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.65 -0.57 4.28e-57 Red blood cell count; BRCA trans rs3960554 0.673 rs112680895 chr7:75623520 G/A cg19862616 chr7:65841803 NCRNA00174 0.57 11.19 0.4 1.14e-26 Eotaxin levels; BRCA cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3806843 0.766 rs2530239 chr5:140062547 C/T cg11822812 chr5:140052017 DND1 -0.32 -8.98 -0.33 2.94e-18 Depressive symptoms (multi-trait analysis); BRCA cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs782590 0.902 rs2586947 chr2:55854009 C/G cg18811423 chr2:55921094 PNPT1 0.7 22.61 0.67 1.32e-83 Metabolic syndrome; BRCA cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg17971929 chr21:40555470 PSMG1 0.47 10.3 0.38 3.92e-23 Menarche (age at onset); BRCA cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg08999081 chr20:33150536 PIGU 0.35 8.75 0.33 1.84e-17 Coronary artery disease; BRCA cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg08601574 chr20:25228251 PYGB -0.38 -9.05 -0.34 1.76e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4077515 0.967 rs4266763 chr9:139289825 C/T cg14019695 chr9:139328340 INPP5E -0.31 -8.0 -0.3 5.73e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs17818399 0.890 rs34752561 chr2:46850150 G/A cg02822958 chr2:46747628 ATP6V1E2 0.55 9.76 0.36 4.36e-21 Height; BRCA cis rs2075371 0.933 rs2544201 chr7:133963561 C/G cg20476274 chr7:133979776 SLC35B4 0.66 19.6 0.61 2.4e-67 Mean platelet volume; BRCA cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg04166393 chr7:2884313 GNA12 0.58 12.47 0.44 4.04e-32 Height; BRCA cis rs4891159 0.790 rs72975925 chr18:74143902 G/A cg24786174 chr18:74118243 ZNF516 -0.77 -17.92 -0.58 1.72e-58 Longevity; BRCA cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg01017244 chr2:74357527 NA 0.56 13.2 0.46 2.49e-35 Gestational age at birth (maternal effect); BRCA trans rs11039798 1.000 rs12281162 chr11:48650491 T/C cg15704280 chr7:45808275 SEPT13 0.51 7.81 0.3 2.33e-14 Axial length; BRCA cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg24450063 chr1:156163899 SLC25A44 0.97 28.51 0.75 5.78e-116 Testicular germ cell tumor; BRCA cis rs7071206 1.000 rs7071206 chr10:79401316 C/T cg00983440 chr10:79422392 NA 0.52 10.26 0.38 5.99e-23 Bone mineral density; BRCA cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg05973401 chr12:123451056 ABCB9 0.41 9.14 0.34 8.18e-19 Platelet count; BRCA cis rs6952808 0.601 rs3800882 chr7:2120758 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -9.61 -0.36 1.7e-20 Bipolar disorder and schizophrenia; BRCA cis rs6788895 1.000 rs16862842 chr3:150484844 A/G cg09723797 chr3:150481914 SIAH2 0.7 8.65 0.32 4.16e-17 Breast cancer; BRCA cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.3 -0.54 3.38e-50 Alzheimer's disease (late onset); BRCA cis rs2286885 1.000 rs2286885 chr9:129246487 A/C cg15282417 chr9:129245246 FAM125B 0.31 7.95 0.3 8.18e-15 Intraocular pressure; BRCA cis rs400736 0.562 rs12129505 chr1:8171734 T/C cg25007680 chr1:8021821 PARK7 -0.36 -8.59 -0.32 6.83e-17 Response to antidepressants and depression; BRCA cis rs1005277 0.577 rs4934906 chr10:38015028 C/T cg00409905 chr10:38381863 ZNF37A -0.45 -9.33 -0.35 1.72e-19 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.59 0.57 8.45e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs425277 0.606 rs2503705 chr1:2076741 A/G cg24578937 chr1:2090814 PRKCZ 0.33 10.47 0.38 8.79e-24 Height; BRCA cis rs887829 0.641 rs10167119 chr2:234589312 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.53 -0.32 1.09e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA trans rs35110281 0.776 rs9306159 chr21:45061839 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.36 0.38 2.29e-23 Mean corpuscular volume; BRCA cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg11663144 chr21:46675770 NA -0.48 -9.62 -0.36 1.54e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2549003 1.000 rs2070723 chr5:131823187 A/G cg02551604 chr5:131831745 NA -0.4 -15.17 -0.51 1.21e-44 Asthma (sex interaction); BRCA cis rs1190552 1.000 rs1190552 chr14:102911907 A/G cg18135206 chr14:102964638 TECPR2 -0.42 -7.84 -0.3 1.87e-14 Blood protein levels; BRCA cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg13114125 chr14:105738426 BRF1 -0.48 -10.41 -0.38 1.53e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.1 0.4 2.76e-26 Coronary artery disease; BRCA trans rs7618501 0.633 rs2353579 chr3:50027774 C/T cg21659725 chr3:3221576 CRBN 0.46 11.55 0.42 3.81e-28 Intelligence (multi-trait analysis); BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg20219911 chr3:52813652 ITIH1 0.29 8.13 0.31 2.16e-15 Cognitive function; BRCA cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg00530320 chr1:46809349 NSUN4 0.47 9.18 0.34 6.13e-19 Menopause (age at onset); BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.47 -8.68 -0.32 3.2e-17 Renal function-related traits (BUN); BRCA cis rs72615157 0.634 rs7789890 chr7:99800559 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.57 8.96 0.33 3.68e-18 Lung function (FEV1/FVC); BRCA cis rs7246967 0.673 rs62120125 chr19:22955099 T/A cg23217946 chr19:22817039 ZNF492 0.5 9.11 0.34 1.04e-18 Bronchopulmonary dysplasia; BRCA cis rs34779708 0.966 rs34605125 chr10:35411246 A/G cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.82e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11608355 0.576 rs1477117 chr12:109888779 A/G cg05360138 chr12:110035743 NA -0.64 -10.69 -0.39 1.15e-24 Neuroticism; BRCA cis rs9394841 0.692 rs35085306 chr6:41856002 A/G cg08135965 chr6:41755394 TOMM6 0.52 8.56 0.32 8.08e-17 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg01528321 chr10:82214614 TSPAN14 0.63 14.18 0.49 7.14e-40 Post bronchodilator FEV1; BRCA cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg23442198 chr4:187126114 CYP4V2 0.95 11.42 0.41 1.23e-27 Blood protein levels; BRCA cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg19318889 chr4:1322082 MAEA 0.48 10.35 0.38 2.65e-23 Longevity; BRCA cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06634786 chr22:41940651 POLR3H -0.63 -10.86 -0.39 2.43e-25 Vitiligo; BRCA cis rs2153535 0.601 rs4140585 chr6:8503298 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 7.08e-41 Motion sickness; BRCA cis rs7615952 1.000 rs7615952 chr3:125649403 A/C cg05084668 chr3:125655381 ALG1L 0.72 12.98 0.46 2.35e-34 Blood pressure (smoking interaction); BRCA cis rs1420338 1.000 rs4723351 chr7:34155813 T/G cg01275685 chr7:34179230 BMPER -0.47 -10.37 -0.38 2.09e-23 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7944584 0.563 rs2280231 chr11:47600438 C/T cg20307385 chr11:47447363 PSMC3 0.76 16.68 0.55 4e-52 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg05985134 chr18:33552581 C18orf21 0.68 12.65 0.45 6.79e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12756686 chr19:29218302 NA 0.57 11.08 0.4 3.26e-26 Methadone dose in opioid dependence; BRCA cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg22800045 chr5:56110881 MAP3K1 0.46 9.1 0.34 1.14e-18 Initial pursuit acceleration; BRCA cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.06 15.87 0.53 4.42e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7395581 0.918 rs10838693 chr11:47350553 G/C cg25783544 chr11:47291846 MADD 0.38 8.44 0.32 2.14e-16 HDL cholesterol; BRCA cis rs2505998 0.833 rs752977 chr10:43588381 T/C cg15436174 chr10:43711423 RASGEF1A -0.43 -8.45 -0.32 2.02e-16 Hirschsprung disease; BRCA cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg24692254 chr21:30365293 RNF160 0.61 13.1 0.46 7.02e-35 Selective IgA deficiency; BRCA cis rs6582630 0.537 rs11520294 chr12:38402705 C/A cg26384229 chr12:38710491 ALG10B 0.77 17.53 0.57 1.92e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg17366294 chr4:99064904 C4orf37 0.41 9.62 0.36 1.46e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg10802521 chr3:52805072 NEK4 -0.31 -8.39 -0.31 3.15e-16 Bipolar disorder; BRCA cis rs1552244 0.938 rs34750074 chr3:10091740 G/A cg00166722 chr3:10149974 C3orf24 0.64 12.76 0.45 2.3e-33 Alzheimer's disease; BRCA cis rs73001065 0.551 rs56397647 chr19:19642795 C/T cg03709012 chr19:19516395 GATAD2A 0.98 14.64 0.5 4.83e-42 LDL cholesterol; BRCA cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg20203395 chr5:56204925 C5orf35 0.61 12.0 0.43 4.47e-30 Initial pursuit acceleration; BRCA cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.74 -0.33 2.02e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6750047 0.546 rs985257 chr2:38283228 A/T cg07380506 chr2:38303506 CYP1B1 -0.54 -11.55 -0.42 3.85e-28 Cutaneous malignant melanoma;Melanoma; BRCA cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg24450063 chr1:156163899 SLC25A44 1.12 36.13 0.82 1.49e-156 Testicular germ cell tumor; BRCA cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg23711669 chr6:146136114 FBXO30 -0.72 -15.96 -0.53 1.63e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 14.6 0.5 6.9e-42 Platelet count; BRCA cis rs72772090 0.539 rs11750464 chr5:96113031 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.57 11.87 0.43 1.6800000000000001e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg24549020 chr5:56110836 MAP3K1 0.6 12.19 0.43 7.39e-31 Initial pursuit acceleration; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg09177884 chr7:1199841 ZFAND2A -0.6 -14.35 -0.49 1.1e-40 Longevity;Endometriosis; BRCA trans rs4596713 0.568 rs7850573 chr9:71747260 C/T cg16512924 chr15:28394682 HERC2 0.39 9.31 0.35 2.07e-19 Headache; BRCA cis rs7312933 0.669 rs7974476 chr12:42542484 C/A cg01256987 chr12:42539512 GXYLT1 -0.41 -8.22 -0.31 1.13e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7246657 0.943 rs34603719 chr19:37794528 T/G cg18154014 chr19:37997991 ZNF793 0.61 11.09 0.4 3.01e-26 Coronary artery calcification; BRCA cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.63 0.36 1.43e-20 Menopause (age at onset); BRCA cis rs11608355 0.515 rs12831026 chr12:109903651 C/T cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs9649213 0.593 rs3801255 chr7:98000929 C/T cg24562669 chr7:97807699 LMTK2 0.46 12.24 0.44 4.08e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs11583043 0.918 rs17525451 chr1:101422409 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.34 0.35 1.56e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs6545883 0.524 rs12713435 chr2:61499789 C/T cg15711740 chr2:61764176 XPO1 0.33 8.09 0.3 3.06e-15 Tuberculosis; BRCA cis rs34891900 0.507 rs2535679 chr22:18202850 A/G cg19898043 chr22:18121309 BCL2L13 0.45 9.65 0.36 1.18e-20 Sum neutrophil eosinophil counts; BRCA cis rs1801251 1.000 rs2675974 chr2:233727071 A/G cg25237894 chr2:233734115 C2orf82 0.41 12.03 0.43 3.29e-30 Coronary artery disease; BRCA cis rs312273 0.563 rs4768319 chr12:41299039 A/C cg17827154 chr12:41323612 CNTN1 -0.35 -8.49 -0.32 1.41e-16 Bipolar disorder; BRCA cis rs4319547 0.695 rs4758662 chr12:122924778 G/A cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.71 -0.36 7.16e-21 Body mass index; BRCA cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.35 7.91 0.3 1.12e-14 Coronary artery disease; BRCA cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg24130564 chr14:104152367 KLC1 -0.43 -10.83 -0.39 3.37e-25 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs4132072 chr6:25717843 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.28e-17 Iron status biomarkers; BRCA trans rs9951602 0.512 rs9946123 chr18:76654557 A/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.28 0.59 2.2e-60 Obesity-related traits; BRCA cis rs6598955 0.616 rs11247890 chr1:26590182 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.98 0.33 2.89e-18 Obesity-related traits; BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg12444411 chr7:2802554 GNA12 -0.33 -8.26 -0.31 8.29e-16 Height; BRCA cis rs6582630 0.519 rs8186881 chr12:38310285 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.22 0.56 7.02e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs10769966 0.515 rs2568069 chr11:8977707 G/A cg00186954 chr11:8933980 ST5;C11orf17 0.33 8.42 0.32 2.5e-16 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7131987 0.630 rs1006409 chr12:29435675 A/G cg09582351 chr12:29534625 ERGIC2 -0.34 -8.37 -0.31 3.63e-16 QT interval; BRCA cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg04455712 chr21:45112962 RRP1B 0.39 10.44 0.38 1.15e-23 Mean corpuscular volume; BRCA cis rs881375 0.669 rs73541868 chr9:123639264 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 10.9 0.4 1.78e-25 Rheumatoid arthritis; BRCA trans rs2204008 0.840 rs11181795 chr12:38401129 A/G cg06521331 chr12:34319734 NA -0.46 -8.48 -0.32 1.58e-16 Bladder cancer; BRCA trans rs11098499 0.863 rs34868248 chr4:120442430 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.2 0.43 6.09e-31 Corneal astigmatism; BRCA cis rs75804782 0.641 rs11885523 chr2:239344263 G/A cg18131467 chr2:239335373 ASB1 -0.62 -8.16 -0.31 1.79e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs875971 0.545 rs1267814 chr7:66044409 G/A cg11764359 chr7:65958608 NA -0.64 -11.32 -0.41 3.39e-27 Aortic root size; BRCA cis rs4953318 0.704 rs10495927 chr2:46352499 A/G cg12428440 chr2:46370979 PRKCE 0.42 9.68 0.36 9.25e-21 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs9400271 0.632 rs9400262 chr6:109591433 T/C cg01475377 chr6:109611718 NA -0.44 -10.39 -0.38 1.79e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs9296095 0.796 rs3846855 chr6:33555877 G/A cg14003231 chr6:33640908 ITPR3 0.45 9.11 0.34 1.02e-18 Platelet count; BRCA cis rs35306767 0.903 rs11253475 chr10:907262 C/A cg26597838 chr10:835615 NA 0.98 16.98 0.56 1.18e-53 Eosinophil percentage of granulocytes; BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.6 -0.45 1.15e-32 Alzheimer's disease; BRCA cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg12311346 chr5:56204834 C5orf35 0.61 12.59 0.45 1.29e-32 Initial pursuit acceleration; BRCA cis rs2745967 0.740 rs2796252 chr1:208067308 C/A cg09788693 chr1:208063733 CD34 0.37 7.84 0.3 1.86e-14 Resting heart rate; BRCA cis rs8062405 1.000 rs7198606 chr16:28875122 T/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4713675 0.565 rs9469566 chr6:33667605 G/T cg14003231 chr6:33640908 ITPR3 0.35 8.84 0.33 9.09e-18 Plateletcrit; BRCA cis rs2797160 1.000 rs2747714 chr6:126007620 A/G cg05901451 chr6:126070800 HEY2 0.39 9.54 0.35 2.89e-20 Endometrial cancer; BRCA cis rs45509595 0.749 rs401763 chr6:27782528 T/C cg26587870 chr6:27730563 NA -0.52 -8.02 -0.3 5.04e-15 Breast cancer; BRCA cis rs9467711 0.591 rs34791189 chr6:26035806 G/A cg08501292 chr6:25962987 TRIM38 0.57 7.81 0.3 2.35e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg15595755 chr5:1867978 NA 0.35 8.01 0.3 5.3e-15 Cardiovascular disease risk factors; BRCA cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.85e-16 Monocyte percentage of white cells; BRCA cis rs2070488 0.775 rs6794397 chr3:38559307 A/G cg24069376 chr3:38537580 EXOG 0.32 9.2 0.34 5.18e-19 Electrocardiographic conduction measures; BRCA cis rs8016982 0.633 rs4363794 chr14:81674327 C/A cg01989461 chr14:81687754 GTF2A1 0.62 14.6 0.5 7.12e-42 Schizophrenia; BRCA cis rs9291683 0.595 rs13150928 chr4:10052961 G/T cg00071950 chr4:10020882 SLC2A9 0.62 14.61 0.5 6.27e-42 Bone mineral density; BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg14004847 chr7:1930337 MAD1L1 -0.42 -7.94 -0.3 8.94e-15 Bipolar disorder and schizophrenia; BRCA cis rs6032067 0.561 rs2743317 chr20:43936931 C/T cg06407657 chr20:43937138 MATN4;RBPJL 0.31 8.47 0.32 1.65e-16 Blood protein levels; BRCA cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.13e-54 Bladder cancer; BRCA cis rs1401999 0.628 rs6798870 chr3:183740350 G/A cg20387954 chr3:183756860 HTR3D 0.4 9.02 0.34 2.26e-18 Anterior chamber depth; BRCA cis rs4642101 0.597 rs9865624 chr3:12822786 T/A cg24848339 chr3:12840334 CAND2 0.43 11.41 0.41 1.43e-27 QRS complex (12-leadsum); BRCA cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg08213375 chr14:104286397 PPP1R13B 0.66 18.77 0.6 5.93e-63 Schizophrenia; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg09177884 chr7:1199841 ZFAND2A -0.39 -8.94 -0.33 4.03e-18 Longevity;Endometriosis; BRCA cis rs1904096 0.506 rs6841121 chr4:95222995 G/A cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.18 -0.37 1.22e-22 Type 2 diabetes; BRCA cis rs10463316 0.817 rs2112419 chr5:150797804 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.58 -0.32 7.32e-17 Metabolite levels (Pyroglutamine); BRCA cis rs7301826 0.651 rs7299281 chr12:131303132 G/A cg11011512 chr12:131303247 STX2 -0.45 -11.27 -0.41 5.41e-27 Plasma plasminogen activator levels; BRCA cis rs10752881 0.967 rs12404594 chr1:182988027 G/A ch.1.3577855R chr1:183094577 LAMC1 0.59 15.31 0.52 2.67e-45 Colorectal cancer; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg07308232 chr7:1071921 C7orf50 -0.42 -8.45 -0.32 1.9e-16 Longevity;Endometriosis; BRCA cis rs4780401 0.609 rs4781141 chr16:11808769 A/C cg01061890 chr16:11836724 TXNDC11 -0.55 -13.08 -0.46 8.08e-35 Rheumatoid arthritis; BRCA cis rs2624839 0.704 rs13064381 chr3:50233317 C/T cg24110177 chr3:50126178 RBM5 -0.47 -11.71 -0.42 7.98e-29 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg07308232 chr7:1071921 C7orf50 -0.5 -10.49 -0.38 7.27e-24 Longevity;Endometriosis; BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg01262667 chr19:19385393 TM6SF2 -0.42 -10.9 -0.4 1.66e-25 Tonsillectomy; BRCA cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg22972055 chr7:872293 UNC84A 0.39 8.09 0.3 3.04e-15 Cerebrospinal P-tau181p levels; BRCA cis rs78663649 0.908 rs79083128 chr19:16556222 G/C cg05286348 chr19:16641544 CHERP -0.68 -8.9 -0.33 5.75e-18 White blood cell count; BRCA cis rs7474896 0.583 rs10827817 chr10:37997974 A/G cg25427524 chr10:38739819 LOC399744 -0.52 -9.22 -0.34 4.17e-19 Obesity (extreme); BRCA cis rs7647973 1.000 rs11928090 chr3:49604904 G/A cg07636037 chr3:49044803 WDR6 0.73 15.74 0.53 2.09e-47 Menarche (age at onset); BRCA trans rs7395662 0.782 rs66468703 chr11:48738773 T/C cg00717180 chr2:96193071 NA -0.32 -8.77 -0.33 1.61e-17 HDL cholesterol; BRCA cis rs72781680 0.898 rs12619592 chr2:23971415 C/A cg20701182 chr2:24300061 SF3B14 0.56 8.63 0.32 5.01e-17 Lymphocyte counts; BRCA cis rs7903847 0.620 rs2297988 chr10:99118382 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.36 -0.31 3.83e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg19678392 chr7:94953810 PON1 -0.4 -8.68 -0.32 3.22e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1005277 0.522 rs289643 chr10:37941494 T/G cg25427524 chr10:38739819 LOC399744 -0.55 -12.51 -0.44 2.71e-32 Extrinsic epigenetic age acceleration; BRCA cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.7 0.39 1.06e-24 Rheumatoid arthritis; BRCA cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.8 -0.36 3.32e-21 Developmental language disorder (linguistic errors); BRCA cis rs965469 0.779 rs6051780 chr20:3334167 A/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.81 -0.33 1.21e-17 IFN-related cytopenia; BRCA cis rs6582630 0.519 rs8189609 chr12:38281408 A/G cg13010199 chr12:38710504 ALG10B 0.5 10.11 0.37 2.19e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7945705 0.719 rs2012680 chr11:8996059 G/A cg12365402 chr11:9010492 NRIP3 -0.44 -10.44 -0.38 1.15e-23 Hemoglobin concentration; BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg18765753 chr7:1198926 ZFAND2A -0.4 -8.0 -0.3 6e-15 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg02733842 chr7:1102375 C7orf50 -0.73 -12.55 -0.44 1.89e-32 Bronchopulmonary dysplasia; BRCA cis rs7582180 0.607 rs6725052 chr2:100935817 G/A cg14675211 chr2:100938903 LONRF2 0.51 11.82 0.42 2.75e-29 Intelligence (multi-trait analysis); BRCA trans rs35110281 0.600 rs914198 chr21:45117456 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.83 0.33 9.62e-18 Mean corpuscular volume; BRCA cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg21395723 chr22:39101663 GTPBP1 0.38 8.32 0.31 5.17e-16 Menopause (age at onset); BRCA cis rs7833986 0.501 rs2976012 chr8:56974343 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.36 0.47 4.56e-36 Height; BRCA cis rs7903847 0.642 rs1048442 chr10:99160152 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.83 -0.33 9.93e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs6956675 0.830 rs4585626 chr7:62671592 C/G cg27518014 chr7:62859535 LOC100287834 -0.44 -7.94 -0.3 9.23e-15 Obesity-related traits; BRCA cis rs11690935 0.959 rs10204502 chr2:172588866 C/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.46 -0.77 1.51e-126 Schizophrenia; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA cis rs62458065 0.513 rs9655340 chr7:32535920 A/G cg20159608 chr7:32802032 NA 0.5 9.59 0.35 2e-20 Metabolite levels (HVA/MHPG ratio); BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.92 -0.3 1.05e-14 Total body bone mineral density; BRCA cis rs7903847 0.642 rs6584128 chr10:99171926 G/T cg08345082 chr10:99160200 RRP12 0.29 8.33 0.31 5.05e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs10504229 0.861 rs6990617 chr8:58182960 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs17270561 0.609 rs1165155 chr6:25795577 A/T cg17691542 chr6:26056736 HIST1H1C 0.43 9.27 0.34 2.89e-19 Iron status biomarkers; BRCA cis rs6570726 0.846 rs372904 chr6:145887425 T/C cg05347473 chr6:146136440 FBXO30 0.39 8.0 0.3 5.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 1.000 rs4147025 chr3:38456531 C/T cg24069376 chr3:38537580 EXOG 0.4 11.52 0.41 4.93e-28 Electrocardiographic conduction measures; BRCA cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg11822812 chr5:140052017 DND1 -0.29 -7.9 -0.3 1.18e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2985684 0.846 rs4476096 chr14:50019391 A/C cg04989706 chr14:50066350 PPIL5 -0.49 -9.97 -0.37 7.31e-22 Carotid intima media thickness; BRCA cis rs6860806 0.507 rs270601 chr5:131656997 T/C cg11843238 chr5:131593191 PDLIM4 0.35 7.94 0.3 9.21e-15 Breast cancer; BRCA cis rs17376456 0.935 rs13156002 chr5:93508931 G/A cg25358565 chr5:93447407 FAM172A 1.18 18.56 0.59 7.72e-62 Diabetic retinopathy; BRCA cis rs10197940 0.648 rs7587301 chr2:152347600 A/G cg06191203 chr2:152266755 RIF1 -0.28 -8.14 -0.31 2.12e-15 Lung cancer; BRCA cis rs478304 0.934 rs574483 chr11:65515277 A/G cg08755490 chr11:65554678 OVOL1 0.55 11.5 0.41 5.88e-28 Acne (severe); BRCA cis rs35146811 0.961 rs1880949 chr7:99722266 A/C cg22906224 chr7:99728672 NA -0.49 -9.38 -0.35 1.1e-19 Coronary artery disease; BRCA trans rs2235573 0.551 rs139898 chr22:38399979 A/G cg19894588 chr14:64061835 NA 0.37 8.95 0.33 3.8e-18 Glioblastoma;Glioma; BRCA cis rs6570726 0.791 rs1509213 chr6:145783360 G/A cg23711669 chr6:146136114 FBXO30 -0.75 -17.24 -0.56 5.62e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs67460515 0.892 rs4856757 chr3:160999418 A/T cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Parkinson's disease; BRCA cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg11890956 chr21:40555474 PSMG1 1.09 32.69 0.79 1.56e-138 Cognitive function; BRCA cis rs34779708 0.931 rs12268745 chr10:35305989 C/G cg03585969 chr10:35415529 CREM 0.49 10.34 0.38 2.81e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7246657 0.663 rs4803276 chr19:38072330 C/A cg14683738 chr19:37701593 ZNF585B 0.46 7.81 0.3 2.31e-14 Coronary artery calcification; BRCA cis rs637571 0.522 rs606978 chr11:65711517 A/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 9.44 0.35 6.78e-20 Eosinophil percentage of white cells; BRCA cis rs9427116 0.502 rs6699825 chr1:154582970 A/G cg17218026 chr1:154582156 ADAR 0.28 8.68 0.32 3.27e-17 Blood protein levels; BRCA trans rs61931739 0.500 rs28692887 chr12:34457075 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.56 0.35 2.42e-20 Morning vs. evening chronotype; BRCA cis rs1113500 0.932 rs1343205 chr1:108597873 C/G cg06207961 chr1:108661230 NA 0.43 10.49 0.38 7.19e-24 Growth-regulated protein alpha levels; BRCA cis rs6598955 0.671 rs11247901 chr1:26612693 T/A cg04990556 chr1:26633338 UBXN11 0.54 9.04 0.34 1.84e-18 Obesity-related traits; BRCA cis rs6120849 0.754 rs6120828 chr20:33674460 A/G cg24642439 chr20:33292090 TP53INP2 0.58 10.0 0.37 5.54e-22 Protein C levels; BRCA cis rs17685 0.672 rs6465011 chr7:75811297 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.29 -0.31 6.8e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6963495 0.818 rs73190158 chr7:105153943 T/C cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1e-19 Bipolar disorder (body mass index interaction); BRCA cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg23958373 chr8:599963 NA -0.71 -8.22 -0.31 1.1e-15 IgG glycosylation; BRCA cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg06784218 chr1:46089804 CCDC17 0.46 10.93 0.4 1.34e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs11098499 0.863 rs6858592 chr4:120458692 G/A cg25214090 chr10:38739885 LOC399744 0.52 11.78 0.42 4.01e-29 Corneal astigmatism; BRCA cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg14847009 chr1:175162515 KIAA0040 0.25 9.44 0.35 7.06e-20 Alcohol dependence; BRCA cis rs16867321 0.950 rs1919148 chr2:181501758 G/A cg23363182 chr2:181467187 NA -0.44 -8.37 -0.31 3.75e-16 Obesity; BRCA cis rs1707322 0.716 rs6694889 chr1:46101806 A/C cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.58e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2816062 1.000 rs2816062 chr1:18903902 G/A cg18795169 chr1:18902165 NA -0.88 -23.19 -0.68 9.21e-87 Urate levels in lean individuals; BRCA cis rs6088580 0.634 rs6087577 chr20:32955423 C/T cg08999081 chr20:33150536 PIGU 0.39 10.76 0.39 6.12e-25 Glomerular filtration rate (creatinine); BRCA cis rs733175 0.857 rs3796835 chr4:10011530 C/T cg00071950 chr4:10020882 SLC2A9 0.43 8.08 0.3 3.23e-15 Psychosis and Alzheimer's disease; BRCA cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 8.56 0.32 8.4e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2239547 0.522 rs2336669 chr3:52994138 C/T cg11645453 chr3:52864694 ITIH4 -0.44 -10.54 -0.38 4.48e-24 Schizophrenia; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 19.52 0.61 6.96e-67 Platelet count; BRCA cis rs9467711 0.606 rs9379901 chr6:26603866 T/C cg12826209 chr6:26865740 GUSBL1 0.63 8.27 0.31 7.87e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.36 -0.31 3.96e-16 Monocyte percentage of white cells; BRCA cis rs7809950 1.000 rs2395883 chr7:107089670 T/C cg23024343 chr7:107201750 COG5 -0.41 -9.45 -0.35 6.3e-20 Coronary artery disease; BRCA trans rs2797160 1.000 rs6904992 chr6:126016003 G/A cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA cis rs60843830 0.661 rs62116681 chr2:104197 A/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.66 0.32 3.82e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -7.93 -0.3 1.01e-14 Personality dimensions; BRCA cis rs57590327 0.503 rs13075250 chr3:81907952 T/C cg07356753 chr3:81810745 GBE1 -0.45 -10.33 -0.38 3.06e-23 Extraversion; BRCA cis rs6088580 0.668 rs1205340 chr20:32923871 G/A cg24642439 chr20:33292090 TP53INP2 -0.51 -11.12 -0.4 2.22e-26 Glomerular filtration rate (creatinine); BRCA cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg05347473 chr6:146136440 FBXO30 0.42 8.12 0.31 2.45e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6840360 0.550 rs6836343 chr4:152497564 A/G cg22705602 chr4:152727874 NA -0.32 -8.15 -0.31 1.93e-15 Intelligence (multi-trait analysis); BRCA trans rs1005277 0.579 rs9299760 chr10:38377920 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.49 -0.32 1.4e-16 Extrinsic epigenetic age acceleration; BRCA cis rs2836950 0.840 rs12482317 chr21:40588241 A/G cg11644478 chr21:40555479 PSMG1 -0.44 -8.71 -0.33 2.52e-17 Menarche (age at onset); BRCA cis rs7493 0.901 rs17879517 chr7:95030646 T/C cg21856205 chr7:94953877 PON1 -0.38 -8.3 -0.31 6.42e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.21 0.34 4.81e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 17.25 0.56 5.25e-55 Hip circumference adjusted for BMI; BRCA cis rs11690935 0.959 rs10174525 chr2:172635697 T/C cg13550731 chr2:172543902 DYNC1I2 -0.93 -32.47 -0.79 2.36e-137 Schizophrenia; BRCA cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.56 -0.44 1.79e-32 Developmental language disorder (linguistic errors); BRCA cis rs72781680 0.799 rs2551332 chr2:23988950 T/C cg08917208 chr2:24149416 ATAD2B 0.65 10.43 0.38 1.31e-23 Lymphocyte counts; BRCA cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg13114125 chr14:105738426 BRF1 -0.48 -11.1 -0.4 2.66e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 14.45 0.5 3.56e-41 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs5758659 0.682 rs133306 chr22:42396150 G/A cg05082376 chr22:42548792 NA -0.31 -7.86 -0.3 1.67e-14 Cognitive function; BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 19.89 0.62 7.35e-69 Platelet count; BRCA cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg06212747 chr3:49208901 KLHDC8B 0.5 7.92 0.3 1.08e-14 Menarche (age at onset); BRCA cis rs4555082 0.874 rs2816621 chr14:105732762 A/T cg27165867 chr14:105738592 BRF1 -0.36 -8.4 -0.32 2.83e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.36 0.35 1.35e-19 Motion sickness; BRCA cis rs7587476 0.906 rs17487792 chr2:215643500 A/G cg04004882 chr2:215674386 BARD1 -0.59 -10.25 -0.38 6.46e-23 Neuroblastoma; BRCA cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 12.88 0.45 6.41e-34 Bipolar disorder; BRCA cis rs9837602 1.000 rs7620228 chr3:99790332 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.14 0.4 1.91e-26 Breast cancer; BRCA cis rs6964587 1.000 rs13231238 chr7:91653851 T/G cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.78e-15 Breast cancer; BRCA trans rs12517041 1.000 rs35670742 chr5:23281811 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg11890956 chr21:40555474 PSMG1 -0.82 -19.65 -0.61 1.39e-67 Cognitive function; BRCA cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs1568889 0.838 rs7933991 chr11:28059761 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.38 0.63 1.74e-71 Bipolar disorder; BRCA cis rs6089584 0.507 rs6061989 chr20:60627893 C/T cg06108461 chr20:60628389 TAF4 -0.73 -15.3 -0.52 3e-45 Body mass index; BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.29 0.41 4.64e-27 Platelet count; BRCA cis rs6785206 0.892 rs6439143 chr3:128425132 C/T cg16766828 chr3:128327626 NA -0.65 -9.94 -0.37 9.29e-22 Lymphocyte percentage of white cells; BRCA cis rs2070488 0.965 rs2284820 chr3:38562579 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -19.61 -0.61 2.28e-67 Electrocardiographic conduction measures; BRCA cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg12564285 chr5:131593104 PDLIM4 0.36 8.06 0.3 3.85e-15 Breast cancer; BRCA cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg06550200 chr5:1325588 CLPTM1L -0.64 -14.06 -0.49 2.66e-39 Lung cancer; BRCA cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.03 -0.34 1.98e-18 Developmental language disorder (linguistic errors); BRCA cis rs6748734 1.000 rs4675868 chr2:241828542 A/C cg02820040 chr2:241836501 C2orf54 -0.53 -10.26 -0.38 5.85e-23 Urinary metabolites; BRCA cis rs10089 0.953 rs6887674 chr5:127531183 G/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 13.87 0.48 1.97e-38 Ileal carcinoids; BRCA cis rs4819052 0.851 rs13048789 chr21:46660714 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1355223 0.583 rs2956074 chr11:34864880 T/C cg11058730 chr11:34937778 PDHX;APIP 0.7 16.38 0.54 1.26e-50 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs561341 1.000 rs542132 chr17:30307193 A/T cg20587970 chr11:113659929 NA -1.2 -22.15 -0.66 4.31e-81 Hip circumference adjusted for BMI; BRCA cis rs7147624 1.000 rs7160390 chr14:66052460 G/A cg03016385 chr14:66212404 NA -0.58 -8.82 -0.33 1.1e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg08999081 chr20:33150536 PIGU 0.37 9.37 0.35 1.26e-19 Coronary artery disease; BRCA cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg26031613 chr14:104095156 KLC1 -0.43 -8.65 -0.32 4.05e-17 Schizophrenia; BRCA cis rs6138458 1.000 rs6707 chr20:24944166 C/T cg06937882 chr20:24974362 C20orf3 -0.47 -8.97 -0.33 3.24e-18 Blood protein levels; BRCA cis rs9399135 0.967 rs7766189 chr6:135353851 A/C cg24558204 chr6:135376177 HBS1L 0.45 12.29 0.44 2.69e-31 Red blood cell count; BRCA cis rs9443645 0.901 rs7742431 chr6:79679577 A/G cg18132916 chr6:79620363 NA -0.44 -9.78 -0.36 3.72e-21 Intelligence (multi-trait analysis); BRCA cis rs4660306 1.000 rs2356559 chr1:45981512 A/G cg24296786 chr1:45957014 TESK2 0.43 8.89 0.33 6.39e-18 Homocysteine levels; BRCA trans rs6951245 1.000 rs74785791 chr7:1088494 T/C cg13565492 chr6:43139072 SRF -0.79 -10.84 -0.39 2.99e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72928364 0.858 rs66598219 chr3:100779435 T/C cg10123952 chr3:100791384 NA 0.58 8.47 0.32 1.63e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs61931739 0.517 rs1843735 chr12:34047389 C/G cg06521331 chr12:34319734 NA -0.58 -11.59 -0.42 2.46e-28 Morning vs. evening chronotype; BRCA cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg01849466 chr14:104193079 ZFYVE21 -0.52 -13.71 -0.48 1.06e-37 Schizophrenia; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.61 11.75 0.42 5.51e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs6918391 chr6:8461178 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.24e-23 Motion sickness; BRCA trans rs2727020 0.553 rs4980447 chr11:49591662 T/C cg03929089 chr4:120376271 NA -0.65 -12.84 -0.45 9.51e-34 Coronary artery disease; BRCA cis rs6586163 0.509 rs2031610 chr10:90754487 T/C cg03111039 chr10:90751583 FAS;ACTA2 0.58 13.45 0.47 1.64e-36 Chronic lymphocytic leukemia; BRCA cis rs9858542 0.953 rs9862080 chr3:49674458 A/G cg03060546 chr3:49711283 APEH -0.58 -11.84 -0.42 2.29e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1555322 0.530 rs2250205 chr20:33867924 C/T cg03689076 chr20:33865952 NA 0.45 8.26 0.31 8.62e-16 Attention deficit hyperactivity disorder; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.58 -12.08 -0.43 2.18e-30 Lymphocyte counts; BRCA cis rs7927592 0.913 rs67947146 chr11:68314980 C/T cg20283391 chr11:68216788 NA -0.47 -9.21 -0.34 4.55e-19 Total body bone mineral density; BRCA cis rs34779708 0.931 rs34304999 chr10:35365705 C/T cg03585969 chr10:35415529 CREM 0.56 11.53 0.42 4.31e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg00717180 chr2:96193071 NA -0.35 -9.85 -0.36 2.05e-21 Coronary artery disease; BRCA cis rs12545109 0.800 rs2670055 chr8:57421575 T/C cg09654669 chr8:57350985 NA -0.4 -8.62 -0.32 5.06e-17 Obesity-related traits; BRCA cis rs2276314 0.857 rs6507157 chr18:33631703 A/C cg05985134 chr18:33552581 C18orf21 0.64 11.57 0.42 2.93e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.04 0.43 3.16e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs6912958 0.525 rs586771 chr6:88064971 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.56 11.83 0.42 2.43e-29 Monocyte percentage of white cells; BRCA cis rs7172677 0.737 rs12910348 chr15:75437642 A/G cg14664628 chr15:75095509 CSK -0.39 -8.08 -0.3 3.19e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg18479299 chr3:125709523 NA -0.5 -8.32 -0.31 5.17e-16 Blood pressure (smoking interaction); BRCA cis rs12493885 0.872 rs9840371 chr3:153796829 C/T cg17054900 chr3:154042577 DHX36 0.53 9.19 0.34 5.62e-19 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs11252926 1.000 rs11252926 chr10:566379 C/T cg18196295 chr10:418757 DIP2C -0.46 -9.44 -0.35 6.74e-20 Psychosis in Alzheimer's disease; BRCA cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA trans rs7786808 0.741 rs11765319 chr7:158226790 A/G cg02030672 chr11:45687055 CHST1 0.37 8.2 0.31 1.31e-15 Obesity-related traits; BRCA trans rs11146838 1 rs11146838 chr10:39149977 A/T cg04469686 chr1:162760199 HSD17B7 -0.42 -8.01 -0.3 5.33e-15 Breast cancer; BRCA cis rs11190604 0.767 rs11190534 chr10:102190930 G/A cg07080220 chr10:102295463 HIF1AN 0.44 9.78 0.36 3.69e-21 Palmitoleic acid (16:1n-7) levels; BRCA trans rs6582630 0.555 rs34145279 chr12:38405588 T/C cg06521331 chr12:34319734 NA -0.51 -9.28 -0.34 2.52e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.83 0.51 5.42e-43 Colorectal cancer; BRCA cis rs6882046 0.513 rs616391 chr5:88038845 C/T cg22951263 chr5:87985283 NA -0.38 -10.6 -0.39 2.82e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs394563 0.601 rs439495 chr6:149793224 A/G cg11245181 chr6:149772854 ZC3H12D 0.27 7.95 0.3 8.76e-15 Dupuytren's disease; BRCA cis rs36051895 0.659 rs57204002 chr9:5062610 T/C cg02405213 chr9:5042618 JAK2 -0.46 -8.62 -0.32 5.13e-17 Pediatric autoimmune diseases; BRCA cis rs595982 0.559 rs17206700 chr19:49361255 A/G cg21252483 chr19:49399788 TULP2 -0.42 -9.55 -0.35 2.64e-20 Red cell distribution width; BRCA cis rs2011503 0.943 rs8102502 chr19:19652746 T/C cg11584989 chr19:19387371 SF4 0.47 10.53 0.38 5.01e-24 Bipolar disorder; BRCA cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg24130564 chr14:104152367 KLC1 0.36 8.15 0.31 1.91e-15 Intelligence (multi-trait analysis); BRCA cis rs2885056 0.783 rs12459941 chr19:10666112 A/G cg04833646 chr19:10679720 CDKN2D -0.99 -22.76 -0.67 2.08e-84 Red cell distribution width; BRCA cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg20887711 chr4:1340912 KIAA1530 0.72 15.98 0.53 1.27e-48 Longevity; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg24642844 chr7:1081250 C7orf50 -0.83 -15.69 -0.53 3.75e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7824557 0.505 rs2736313 chr8:11086942 C/T cg21775007 chr8:11205619 TDH 0.43 8.94 0.33 4.05e-18 Retinal vascular caliber; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg22920501 chr2:26401640 FAM59B 0.95 16.82 0.55 7.55e-53 Gut microbiome composition (summer); BRCA cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg13047869 chr3:10149882 C3orf24 -0.59 -12.45 -0.44 5.44e-32 Alzheimer's disease; BRCA cis rs7713065 0.531 rs2522051 chr5:131797578 C/T cg14196790 chr5:131705035 SLC22A5 0.33 8.63 0.32 4.73e-17 Lung function (FEV1/FVC); BRCA cis rs9831754 0.906 rs2102601 chr3:78410536 G/A cg06138941 chr3:78371609 NA -0.74 -16.24 -0.54 6.3e-50 Calcium levels; BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg03709012 chr19:19516395 GATAD2A -0.74 -16.54 -0.55 2.13e-51 Tonsillectomy; BRCA cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg11764359 chr7:65958608 NA -0.74 -16.3 -0.54 3.5e-50 Aortic root size; BRCA cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg02733842 chr7:1102375 C7orf50 -0.72 -12.42 -0.44 7.02e-32 Bronchopulmonary dysplasia; BRCA cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg02475777 chr4:1388615 CRIPAK 0.67 13.04 0.46 1.26e-34 Longevity; BRCA cis rs7647973 0.593 rs58339610 chr3:49845006 T/A cg07636037 chr3:49044803 WDR6 -0.5 -8.36 -0.31 3.89e-16 Menarche (age at onset); BRCA cis rs2075371 0.965 rs1862049 chr7:133978344 A/T cg11752832 chr7:134001865 SLC35B4 0.52 13.53 0.47 7.65e-37 Mean platelet volume; BRCA cis rs7666738 0.753 rs35146453 chr4:98902278 A/G cg05340658 chr4:99064831 C4orf37 0.63 15.45 0.52 5.32e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs7520050 0.931 rs11576305 chr1:46460046 C/T cg24296786 chr1:45957014 TESK2 0.44 9.81 0.36 2.95e-21 Red blood cell count;Reticulocyte count; BRCA cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg00012203 chr2:219082015 ARPC2 -0.6 -12.59 -0.45 1.26e-32 Colorectal cancer; BRCA cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg19748678 chr4:122722346 EXOSC9 0.53 11.72 0.42 7.14e-29 Type 2 diabetes; BRCA cis rs9486715 0.867 rs4839842 chr6:96955387 A/T cg06623918 chr6:96969491 KIAA0776 0.89 25.79 0.71 4.53e-101 Headache; BRCA cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg06784218 chr1:46089804 CCDC17 0.45 10.84 0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs9467773 0.626 rs6935803 chr6:26350495 A/G cg09904177 chr6:26538194 HMGN4 -0.31 -8.36 -0.31 3.94e-16 Intelligence (multi-trait analysis); BRCA cis rs367615 0.506 rs2963013 chr5:108775811 C/T cg17395555 chr5:108820864 NA -0.41 -12.71 -0.45 3.68e-33 Colorectal cancer (SNP x SNP interaction); BRCA cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.646 rs9487049 chr6:109615905 A/T cg01475377 chr6:109611718 NA -0.4 -8.7 -0.33 2.72e-17 Reticulocyte fraction of red cells; BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg08888203 chr3:10149979 C3orf24 0.56 11.55 0.42 3.8e-28 Alzheimer's disease; BRCA cis rs7582180 0.663 rs1114595 chr2:100960072 T/A cg14675211 chr2:100938903 LONRF2 0.44 9.73 0.36 5.87e-21 Intelligence (multi-trait analysis); BRCA cis rs7301826 0.610 rs7957899 chr12:131279076 T/C cg11011512 chr12:131303247 STX2 0.5 13.34 0.47 5.45e-36 Plasma plasminogen activator levels; BRCA cis rs798554 0.591 rs757791 chr7:2867296 A/G cg13628971 chr7:2884303 GNA12 0.4 8.84 0.33 9.18e-18 Height; BRCA trans rs61931739 0.534 rs11053073 chr12:34202412 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.53 0.35 3.12e-20 Morning vs. evening chronotype; BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.67 0.61 1.03e-67 Platelet count; BRCA cis rs2243480 1.000 rs781157 chr7:65478311 G/A cg18252515 chr7:66147081 NA -0.84 -12.26 -0.44 3.6e-31 Diabetic kidney disease; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg08470875 chr2:26401718 FAM59B -0.71 -11.54 -0.42 4.1e-28 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs17270561 0.609 rs1165208 chr6:25803904 G/A cg16482183 chr6:26056742 HIST1H1C 0.41 8.8 0.33 1.32e-17 Iron status biomarkers; BRCA cis rs11190604 1.000 rs10883512 chr10:102308516 A/G cg07080220 chr10:102295463 HIF1AN 0.65 15.26 0.52 4.46e-45 Palmitoleic acid (16:1n-7) levels; BRCA cis rs709400 0.628 rs7150317 chr14:103921691 C/G cg12935359 chr14:103987150 CKB -0.59 -14.08 -0.49 2.04e-39 Body mass index; BRCA cis rs72781680 0.611 rs72781692 chr2:24263319 T/G cg20701182 chr2:24300061 SF3B14 0.68 12.57 0.45 1.53e-32 Lymphocyte counts; BRCA trans rs11098499 0.821 rs28665282 chr4:120384186 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg22535103 chr8:58192502 C8orf71 -0.6 -13.19 -0.46 2.71e-35 Developmental language disorder (linguistic errors); BRCA cis rs939658 0.805 rs2177056 chr15:79441489 T/C cg17916960 chr15:79447300 NA -0.43 -10.98 -0.4 8.11e-26 Refractive error; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg08470875 chr2:26401718 FAM59B 0.76 11.94 0.43 8.04e-30 Gut microbiome composition (summer); BRCA cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg10932868 chr11:921992 NA 0.47 12.09 0.43 1.93e-30 Alzheimer's disease (late onset); BRCA cis rs34779708 0.931 rs4934702 chr10:35323074 T/C cg03585969 chr10:35415529 CREM 0.49 10.22 0.37 8.28e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11190604 0.943 rs3750631 chr10:102279294 A/G cg07080220 chr10:102295463 HIF1AN 0.61 14.33 0.49 1.36e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1707322 0.963 rs6666763 chr1:46436451 C/A cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.85 -0.42 2.09e-29 Gut microbiome composition (summer); BRCA cis rs1113500 0.862 rs11185264 chr1:108640506 T/C cg06207961 chr1:108661230 NA 0.45 10.77 0.39 5.48e-25 Growth-regulated protein alpha levels; BRCA cis rs9394841 0.667 rs9394831 chr6:41753084 C/T cg08135965 chr6:41755394 TOMM6 0.5 8.13 0.31 2.18e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA trans rs7980799 0.935 rs7312012 chr12:33517984 A/G cg26384229 chr12:38710491 ALG10B -0.4 -8.5 -0.32 1.35e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg25173405 chr17:45401733 C17orf57 0.49 9.93 0.37 1e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs875971 0.862 rs937494 chr7:65764678 T/A cg18876405 chr7:65276391 NA -0.51 -11.54 -0.42 3.95e-28 Aortic root size; BRCA cis rs9790314 0.521 rs1450523 chr3:161077270 G/A cg03342759 chr3:160939853 NMD3 -0.56 -11.99 -0.43 4.87e-30 Morning vs. evening chronotype; BRCA cis rs9859260 0.744 rs492288 chr3:195784210 C/T cg03462622 chr3:195777018 TFRC -0.38 -8.63 -0.32 4.83e-17 Mean corpuscular volume; BRCA cis rs586533 0.837 rs630095 chr11:99503356 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.31 2.76e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs3824867 0.920 rs7130693 chr11:47452321 T/C cg20307385 chr11:47447363 PSMC3 -0.51 -11.48 -0.41 6.99e-28 Mean corpuscular hemoglobin; BRCA cis rs2415984 0.622 rs7156444 chr14:46933296 C/G cg14871534 chr14:47121158 RPL10L -0.37 -8.82 -0.33 1.12e-17 Number of children ever born; BRCA cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -10.9 -0.4 1.77e-25 IgG glycosylation; BRCA cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11890956 chr21:40555474 PSMG1 1.06 30.4 0.77 3.01e-126 Cognitive function; BRCA trans rs9329221 0.651 rs2975648 chr8:10135976 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -8.74 -0.33 2e-17 Neuroticism; BRCA cis rs35306767 0.903 rs12763396 chr10:927357 C/A cg20503657 chr10:835505 NA 1.05 18.77 0.6 5.82e-63 Eosinophil percentage of granulocytes; BRCA cis rs1552244 1.000 rs17032396 chr3:10153559 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.92 -18.06 -0.58 3.42e-59 Alzheimer's disease; BRCA cis rs6570726 0.818 rs437147 chr6:145875423 A/T cg13319975 chr6:146136371 FBXO30 -0.4 -9.11 -0.34 1.06e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088590 0.735 rs6088618 chr20:33409350 G/A cg08999081 chr20:33150536 PIGU 0.43 11.53 0.41 4.5e-28 Coronary artery disease; BRCA cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg13319975 chr6:146136371 FBXO30 -0.59 -13.1 -0.46 6.95e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.704 rs12535154 chr7:148895304 G/A cg23583168 chr7:148888333 NA -0.96 -25.96 -0.72 5.37e-102 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs747782 0.585 rs1316604 chr11:48279796 G/A cg15704280 chr7:45808275 SEPT13 0.52 7.83 0.3 1.97e-14 Intraocular pressure; BRCA cis rs6964587 0.839 rs13246743 chr7:91453945 G/T cg17063962 chr7:91808500 NA 0.51 11.61 0.42 2.16e-28 Breast cancer; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg14004847 chr7:1930337 MAD1L1 -0.41 -7.97 -0.3 7.42e-15 Bipolar disorder and schizophrenia; BRCA cis rs61931739 0.517 rs10844815 chr12:34245150 G/A cg06521331 chr12:34319734 NA -0.65 -12.01 -0.43 3.99e-30 Morning vs. evening chronotype; BRCA cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg16339924 chr4:17578868 LAP3 0.6 14.63 0.5 4.92e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2070488 0.804 rs13092473 chr3:38458958 A/G cg24069376 chr3:38537580 EXOG 0.32 8.83 0.33 1e-17 Electrocardiographic conduction measures; BRCA trans rs11098499 0.739 rs10031033 chr4:120151452 C/T cg25214090 chr10:38739885 LOC399744 0.44 9.47 0.35 5.39e-20 Corneal astigmatism; BRCA cis rs6430585 0.702 rs73958637 chr2:136546927 C/T cg07169764 chr2:136633963 MCM6 1.28 30.68 0.77 8.99e-128 Corneal structure; BRCA cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.33 0.68 1.52e-87 Chronic sinus infection; BRCA cis rs10751667 1.000 rs10794349 chr11:945678 T/C ch.11.42038R chr11:967971 AP2A2 0.58 18.85 0.6 2.47e-63 Alzheimer's disease (late onset); BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg08470875 chr2:26401718 FAM59B -0.58 -9.84 -0.36 2.37e-21 Gut microbiome composition (summer); BRCA cis rs908922 0.676 rs1572533 chr1:152509742 T/C cg20991723 chr1:152506922 NA 0.39 8.93 0.33 4.56e-18 Hair morphology; BRCA cis rs7762018 0.769 rs4716385 chr6:170127608 G/T cg19338460 chr6:170058176 WDR27 -0.48 -7.87 -0.3 1.55e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs6032067 0.673 rs36019441 chr20:43892401 G/A cg20256260 chr20:43936981 MATN4;RBPJL 0.34 8.17 0.31 1.6e-15 Blood protein levels; BRCA cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg18904891 chr8:8559673 CLDN23 0.58 11.59 0.42 2.49e-28 Obesity-related traits; BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg26516362 chr5:178986906 RUFY1 0.39 10.11 0.37 2.08e-22 Lung cancer; BRCA cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.93 -0.43 9.31e-30 Personality dimensions; BRCA cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.31 -0.38 3.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.77 0.62 3.21e-68 Platelet count; BRCA cis rs6429082 0.791 rs291394 chr1:235651682 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 13.54 0.47 6.94e-37 Adiposity; BRCA cis rs7760949 0.889 rs9475807 chr6:13934597 T/C cg27413430 chr6:13925136 RNF182 0.46 9.24 0.34 3.66e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs4820294 1.000 rs62236665 chr22:38059847 C/A cg21798802 chr22:38057573 PDXP 0.5 13.34 0.47 5.58e-36 Fat distribution (HIV); BRCA cis rs2180341 0.814 rs7768435 chr6:127737038 A/C cg27446573 chr6:127587934 RNF146 0.67 15.25 0.52 5.03e-45 Breast cancer; BRCA cis rs6964587 1.000 rs35317449 chr7:91637010 G/A cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.16e-32 Breast cancer; BRCA cis rs1008375 0.900 rs4698622 chr4:17589557 C/T cg16339924 chr4:17578868 LAP3 0.76 18.27 0.59 2.49e-60 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.36 0.61 4.72e-66 Platelet count; BRCA cis rs7020830 0.928 rs11544336 chr9:37089150 A/G cg14294708 chr9:37120828 ZCCHC7 1.16 40.51 0.85 1.2e-178 Schizophrenia; BRCA cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg20701182 chr2:24300061 SF3B14 0.71 12.98 0.46 2.33e-34 Lymphocyte counts; BRCA cis rs10992471 0.756 rs10992319 chr9:95127895 G/A cg14631576 chr9:95140430 CENPP -0.37 -9.04 -0.34 1.92e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs40363 0.723 rs4785936 chr16:3535116 A/G cg22508957 chr16:3507546 NAT15 -0.52 -7.85 -0.3 1.82e-14 Tuberculosis; BRCA cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg09359103 chr1:154839909 KCNN3 -0.56 -14.55 -0.5 1.26e-41 Prostate cancer; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.05 19.99 0.62 2.04e-69 Platelet count; BRCA cis rs11955398 0.716 rs2061250 chr5:59917678 C/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.49e-19 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.605 rs10464620 chr7:107135653 A/G cg02696742 chr7:106810147 HBP1 0.5 7.87 0.3 1.48e-14 Coronary artery disease; BRCA cis rs7666738 0.753 rs11932536 chr4:98930105 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs600231 0.665 rs1621277 chr11:65221954 A/G cg01292856 chr11:65242576 NA -0.36 -9.25 -0.34 3.24e-19 Bone mineral density; BRCA cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg26248373 chr2:1572462 NA -0.67 -15.83 -0.53 7.21e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3125734 0.633 rs10821968 chr10:63993905 C/T cg09941381 chr10:64027924 RTKN2 0.28 8.21 0.31 1.25e-15 Rheumatoid arthritis; BRCA trans rs11098499 0.690 rs34818745 chr4:120257055 T/C cg25214090 chr10:38739885 LOC399744 0.52 11.72 0.42 7.25e-29 Corneal astigmatism; BRCA cis rs921968 0.565 rs6436073 chr2:219618237 A/C cg02176678 chr2:219576539 TTLL4 -0.42 -11.25 -0.41 6.19e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg00149659 chr3:10157352 C3orf10 0.84 14.7 0.5 2.39e-42 Alzheimer's disease; BRCA cis rs6598955 0.543 rs79778574 chr1:26538482 A/G cg12744634 chr1:26560303 CCDC21 0.33 8.92 0.33 4.74e-18 Obesity-related traits; BRCA cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg06713675 chr4:122721982 EXOSC9 -0.54 -12.58 -0.45 1.41e-32 Type 2 diabetes; BRCA cis rs8062405 0.723 rs12445744 chr16:28588395 A/C cg16576597 chr16:28551801 NUPR1 0.35 9.46 0.35 5.9e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA trans rs877282 0.755 rs1769242 chr10:787896 T/C cg22713356 chr15:30763199 NA 1.1 21.99 0.66 3.3e-80 Uric acid levels; BRCA cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg26408565 chr15:76604113 ETFA -0.48 -10.43 -0.38 1.26e-23 Blood metabolite levels; BRCA cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.59 12.43 0.44 6.38e-32 Age-related macular degeneration (geographic atrophy); BRCA cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg22875332 chr1:76189707 ACADM 0.7 15.04 0.51 5.42e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs13046373 0.535 rs2832966 chr21:32017177 A/G cg16812893 chr21:31813075 KRTAP15-1 0.37 9.28 0.34 2.66e-19 HDL cholesterol; BRCA cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.48 0.35 4.81e-20 Motion sickness; BRCA cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.55 -0.32 9.19e-17 Monocyte percentage of white cells; BRCA cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10189230 0.967 rs7573758 chr2:222357326 G/T cg14652038 chr2:222343519 EPHA4 0.47 13.22 0.46 1.94e-35 Urate levels in lean individuals; BRCA cis rs250677 0.522 rs10050928 chr5:148353463 C/A cg18129178 chr5:148520854 ABLIM3 0.54 10.26 0.38 5.53e-23 Breast cancer; BRCA cis rs6745190 0.557 rs13011738 chr2:181985742 A/G cg00481216 chr2:181971175 NA 0.46 8.72 0.33 2.36e-17 White blood cell count; BRCA cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg20701182 chr2:24300061 SF3B14 0.59 9.29 0.35 2.35e-19 Lymphocyte counts; BRCA cis rs56104184 0.725 rs1466896 chr19:49385253 C/G cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.78 -0.36 3.92e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs858239 0.600 rs7799422 chr7:23128413 G/A cg23682824 chr7:23144976 KLHL7 0.45 11.82 0.42 2.6e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs858239 0.669 rs6461688 chr7:23116615 G/A cg23682824 chr7:23144976 KLHL7 0.34 8.78 0.33 1.49e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs3771570 1.000 rs55645375 chr2:242269024 A/G cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs71227278 1 rs71227278 chr12:54358047 C/CTTAA cg26079753 chr12:54355528 NA -0.43 -11.1 -0.4 2.68e-26 Urinary tract infection frequency; BRCA cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg15605315 chr1:45957053 TESK2 -0.41 -8.32 -0.31 5.18e-16 Red blood cell count;Reticulocyte count; BRCA trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.18 -0.56 1.12e-54 Intelligence (multi-trait analysis); BRCA cis rs11764590 0.724 rs55669426 chr7:2090129 G/C cg23422044 chr7:1970798 MAD1L1 -0.44 -9.39 -0.35 1.04e-19 Neuroticism; BRCA cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg08508325 chr11:3079039 CARS 0.44 16.38 0.54 1.36e-50 Longevity; BRCA cis rs6772849 0.896 rs61112519 chr3:128338176 T/A cg16766828 chr3:128327626 NA -0.39 -8.65 -0.32 4.17e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs3820928 1.000 rs3820927 chr2:227779191 C/A cg11843606 chr2:227700838 RHBDD1 -0.39 -8.49 -0.32 1.39e-16 Pulmonary function; BRCA cis rs151227923 1 rs151227923 chr7:155106564 C/T cg04811098 chr7:155088454 INSIG1 0.39 10.26 0.38 5.76e-23 Stem cell growth factor beta levels; BRCA cis rs1707322 1.000 rs1707337 chr1:46508769 A/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.87 -0.4 2.17e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11958404 0.789 rs72818145 chr5:157476552 G/C cg05962755 chr5:157440814 NA 0.54 9.55 0.35 2.72e-20 IgG glycosylation; BRCA cis rs6964587 1.000 rs10488512 chr7:91753579 C/T cg17063962 chr7:91808500 NA 0.55 13.04 0.46 1.21e-34 Breast cancer; BRCA cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg17971929 chr21:40555470 PSMG1 0.77 18.02 0.58 4.98e-59 Cognitive function; BRCA cis rs10174077 0.687 rs10172023 chr2:152476028 C/G cg19508488 chr2:152266495 RIF1 0.47 9.13 0.34 9.09e-19 Squamous cell lung carcinoma; BRCA cis rs34779708 0.931 rs35136660 chr10:35385973 C/A cg03585969 chr10:35415529 CREM 0.56 11.54 0.42 3.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs35740288 0.539 rs34362339 chr15:86337628 C/T cg20737812 chr15:86336631 KLHL25 -0.4 -9.78 -0.36 3.73e-21 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs4803468 0.967 rs3745290 chr19:41890003 C/T cg09537434 chr19:41945824 ATP5SL -0.98 -23.71 -0.68 1.3e-89 Height; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg16606324 chr3:10149918 C3orf24 -0.55 -10.84 -0.39 2.92e-25 Alzheimer's disease; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.62 10.03 0.37 4.52e-22 Renal function-related traits (BUN); BRCA cis rs7824557 0.603 rs2249804 chr8:11215617 C/G cg21775007 chr8:11205619 TDH 0.65 15.72 0.53 2.43e-47 Retinal vascular caliber; BRCA cis rs7267979 1.000 rs7267979 chr20:25298087 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.18 0.34 6e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.98 0.56 1.17e-53 Bladder cancer; BRCA cis rs912057 0.601 rs1294405 chr6:6737591 A/G cg06612196 chr6:6737390 NA 0.55 13.23 0.46 1.65e-35 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9811920 0.928 rs2130369 chr3:99873317 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.49 11.2 0.41 1.04e-26 Axial length; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg16145915 chr7:1198662 ZFAND2A -0.63 -15.39 -0.52 1.1e-45 Longevity;Endometriosis; BRCA cis rs7824557 0.628 rs11250129 chr8:11202154 G/A cg21775007 chr8:11205619 TDH 0.72 16.75 0.55 1.76e-52 Retinal vascular caliber; BRCA cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg22800045 chr5:56110881 MAP3K1 0.63 12.36 0.44 1.26e-31 Initial pursuit acceleration; BRCA trans rs11098499 0.863 rs3822194 chr4:120471648 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs35306767 0.903 rs7077278 chr10:911291 A/G cg20503657 chr10:835505 NA -1.03 -17.82 -0.58 5.89e-58 Eosinophil percentage of granulocytes; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg12564285 chr5:131593104 PDLIM4 0.43 11.04 0.4 4.77e-26 Acylcarnitine levels; BRCA cis rs11231017 0.507 rs2178258 chr11:62069893 C/T cg23876832 chr11:62092739 NA 0.32 8.18 0.31 1.59e-15 HIV-1 viral setpoint; BRCA cis rs7829975 0.606 rs6422352 chr8:8794193 A/G cg06636001 chr8:8085503 FLJ10661 -0.54 -11.73 -0.42 6.41e-29 Mood instability; BRCA trans rs11992162 0.613 rs56094399 chr8:11797470 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -10.06 -0.37 3.25e-22 Monocyte count; BRCA trans rs9409565 0.826 rs4744338 chr9:97158965 C/T cg05679027 chr9:99775184 HIATL2 0.42 9.43 0.35 7.65e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA trans rs7615952 0.599 rs6779141 chr3:125709995 A/T cg07211511 chr3:129823064 LOC729375 -0.62 -11.05 -0.4 4.24e-26 Blood pressure (smoking interaction); BRCA cis rs1865760 0.964 rs6932113 chr6:25913098 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.34 0.38 2.87e-23 Height; BRCA cis rs826838 0.935 rs7301104 chr12:39182821 C/T cg13010199 chr12:38710504 ALG10B 0.53 11.07 0.4 3.38e-26 Heart rate; BRCA cis rs332507 0.830 rs3821532 chr3:124402618 G/T cg05980111 chr3:124395277 KALRN 0.38 8.75 0.33 1.89e-17 Plateletcrit; BRCA cis rs7786877 0.723 rs7812123 chr7:100211556 C/A cg20848291 chr7:100343083 ZAN -0.58 -10.69 -0.39 1.19e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg14926445 chr8:58193284 C8orf71 -0.44 -8.47 -0.32 1.74e-16 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg22875332 chr1:76189707 ACADM 0.66 15.71 0.53 3e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs868036 1.000 rs4776377 chr15:68103387 T/C cg05925327 chr15:68127851 NA -0.31 -7.9 -0.3 1.23e-14 Restless legs syndrome; BRCA cis rs3125734 0.719 rs10821972 chr10:64043735 G/A cg19640130 chr10:64028056 RTKN2 -0.3 -8.2 -0.31 1.34e-15 Rheumatoid arthritis; BRCA cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg18446336 chr7:2847575 GNA12 -0.35 -8.16 -0.31 1.73e-15 Height; BRCA cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg26597838 chr10:835615 NA 1.02 15.64 0.53 6.11e-47 Eosinophil percentage of granulocytes; BRCA cis rs34779708 0.733 rs59287215 chr10:35543994 C/T cg03585969 chr10:35415529 CREM 0.45 9.11 0.34 1.01e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs250677 1.000 rs36079 chr5:148430504 G/A cg18129178 chr5:148520854 ABLIM3 -0.56 -11.25 -0.41 6.28e-27 Breast cancer; BRCA cis rs67478160 0.619 rs12897150 chr14:104319530 A/T cg26031613 chr14:104095156 KLC1 -0.43 -8.42 -0.32 2.55e-16 Schizophrenia; BRCA cis rs6088813 1.000 rs6142358 chr20:33960308 A/G cg14752227 chr20:34000481 UQCC 0.41 8.82 0.33 1.05e-17 Height; BRCA cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg06784218 chr1:46089804 CCDC17 0.52 12.53 0.44 2.36e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs11252926 0.565 rs60553947 chr10:474284 T/C cg00953403 chr17:74099816 EXOC7 -0.45 -8.22 -0.31 1.14e-15 Psychosis in Alzheimer's disease; BRCA cis rs2964802 0.505 rs4314375 chr5:10803435 C/T cg14521931 chr5:10832172 NA 0.58 12.97 0.46 2.6e-34 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs4363385 0.720 rs9325996 chr1:152965347 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.51 -0.35 3.95e-20 Inflammatory skin disease; BRCA cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs11190604 1.000 rs4919470 chr10:102298920 C/T cg07080220 chr10:102295463 HIF1AN 0.63 13.21 0.46 2.15e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg05294307 chr14:35346193 BAZ1A -0.55 -9.8 -0.36 3.16e-21 Psoriasis; BRCA cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg12667521 chr19:29218732 NA 0.47 8.75 0.33 1.93e-17 Methadone dose in opioid dependence; BRCA cis rs858239 0.539 rs870476 chr7:23193271 C/T cg23682824 chr7:23144976 KLHL7 0.41 10.9 0.4 1.67e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs6840258 1.000 rs17604480 chr4:87970127 C/A cg08197287 chr4:87952173 AFF1 -0.45 -8.98 -0.33 2.93e-18 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs9443189 0.570 rs775075 chr6:76380035 A/C cg01950844 chr6:76311363 SENP6 -0.84 -13.48 -0.47 1.32e-36 Prostate cancer; BRCA cis rs3617 0.532 rs9836499 chr3:52904524 G/T cg11645453 chr3:52864694 ITIH4 -0.37 -9.7 -0.36 7.37e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs9287719 0.967 rs6721739 chr2:10751246 G/T cg00105475 chr2:10696890 NA -0.45 -10.41 -0.38 1.55e-23 Prostate cancer; BRCA cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg11530693 chr1:120165357 ZNF697 0.62 14.94 0.51 1.68e-43 Systemic lupus erythematosus; BRCA cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg25319279 chr11:5960081 NA -0.42 -8.41 -0.32 2.67e-16 DNA methylation (variation); BRCA cis rs12986413 0.619 rs1859954 chr19:2145481 G/T cg09261902 chr19:2140048 AP3D1 -0.37 -9.77 -0.36 4.33e-21 Height; BRCA cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg10932868 chr11:921992 NA 0.39 9.29 0.35 2.31e-19 Alzheimer's disease (late onset); BRCA trans rs561341 0.883 rs1034626 chr17:30219500 C/G cg27661571 chr11:113659931 NA 0.53 8.44 0.32 2.2e-16 Hip circumference adjusted for BMI; BRCA cis rs2230307 0.706 rs564562 chr1:100471566 T/C cg24955406 chr1:100503596 HIAT1 0.54 9.43 0.35 7.66e-20 Carotid intima media thickness; BRCA cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg13010199 chr12:38710504 ALG10B -0.4 -9.14 -0.34 8.46e-19 Morning vs. evening chronotype; BRCA cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg11890956 chr21:40555474 PSMG1 -0.87 -23.0 -0.67 9.6e-86 Cognitive function; BRCA cis rs909002 0.925 rs7524405 chr1:32108579 A/C cg13919466 chr1:32135498 COL16A1 0.23 7.96 0.3 7.67e-15 Intelligence (multi-trait analysis); BRCA cis rs4948102 0.731 rs7800001 chr7:56072010 T/C cg09872392 chr7:56161020 PHKG1 -0.37 -8.32 -0.31 5.44e-16 Plasma homocysteine levels (post-methionine load test); BRCA cis rs12701220 0.504 rs12702092 chr7:1145868 G/A cg26769984 chr7:1090371 C7orf50 0.49 8.78 0.33 1.49e-17 Bronchopulmonary dysplasia; BRCA cis rs3806843 1.000 rs12717860 chr5:140171442 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.96 -0.37 8.34e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg18876405 chr7:65276391 NA -0.51 -11.63 -0.42 1.67e-28 Aortic root size; BRCA cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg11663144 chr21:46675770 NA -0.56 -13.19 -0.46 2.72e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg00825309 chr19:58991885 ZNF446 -0.64 -14.4 -0.5 6.13e-41 Uric acid clearance; BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg03188948 chr7:1209495 NA 0.78 11.27 0.41 5.59e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4319547 0.661 rs7398014 chr12:122943980 T/C cg05707623 chr12:122985044 ZCCHC8 -0.52 -10.14 -0.37 1.7e-22 Body mass index; BRCA cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg26031613 chr14:104095156 KLC1 -0.42 -8.35 -0.31 4.22e-16 Schizophrenia; BRCA cis rs1829883 0.898 rs2460684 chr5:98776329 C/T cg08333243 chr5:99726346 NA -0.35 -7.98 -0.3 6.56e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs17685 0.753 rs1104878 chr7:75685593 G/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.94 -0.33 4.08e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs57221529 0.766 rs12522140 chr5:587261 C/A cg09021430 chr5:549028 NA -0.68 -14.14 -0.49 1.07e-39 Lung disease severity in cystic fibrosis; BRCA cis rs7607369 0.617 rs12987009 chr2:219658170 A/T cg02176678 chr2:219576539 TTLL4 -0.47 -12.26 -0.44 3.34e-31 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg19717773 chr7:2847554 GNA12 -0.42 -8.53 -0.32 1.04e-16 Height; BRCA cis rs35110281 0.693 rs4819290 chr21:45122713 C/T cg01579765 chr21:45077557 HSF2BP -0.42 -11.45 -0.41 1.01e-27 Mean corpuscular volume; BRCA cis rs9400271 0.632 rs6930698 chr6:109590304 A/G cg21918786 chr6:109611834 NA -0.32 -8.05 -0.3 4.14e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg13880726 chr7:1868755 MAD1L1 -0.43 -8.14 -0.31 2.09e-15 Bipolar disorder and schizophrenia; BRCA cis rs7944584 0.552 rs12361415 chr11:47474146 T/G cg03711944 chr11:47377212 SPI1 -0.44 -10.1 -0.37 2.28e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg22974920 chr21:40686053 BRWD1 -0.35 -7.91 -0.3 1.11e-14 Menarche (age at onset); BRCA cis rs1448094 0.512 rs12309296 chr12:86241566 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.17 -0.34 6.19e-19 Major depressive disorder; BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg00814883 chr7:100076585 TSC22D4 -0.49 -10.26 -0.38 5.9e-23 Platelet count; BRCA cis rs877529 0.625 rs714016 chr22:39532554 G/T cg18708252 chr22:39545030 CBX7 0.38 9.01 0.34 2.45e-18 Multiple myeloma; BRCA cis rs4845570 1.000 rs3790514 chr1:151744168 T/C cg07092448 chr1:151763213 TDRKH -0.88 -17.0 -0.56 9.09e-54 Coronary artery disease; BRCA cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg11833968 chr6:79620685 NA -0.43 -9.58 -0.35 2.12e-20 Intelligence (multi-trait analysis); BRCA cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg13271783 chr10:134563150 INPP5A -0.47 -9.95 -0.37 8.73e-22 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg26647111 chr11:31128758 NA -0.43 -9.17 -0.34 6.54e-19 Red blood cell count; BRCA trans rs3733585 0.673 rs4495037 chr4:9954050 C/G cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 8.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4862750 0.914 rs1346127 chr4:187876389 C/T cg11301795 chr4:187892539 NA 0.3 9.7 0.36 7.88e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs4302748 0.862 rs11772280 chr7:36186110 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4891159 0.756 rs3892540 chr18:74118058 C/T cg24786174 chr18:74118243 ZNF516 -0.78 -18.93 -0.6 8.67e-64 Longevity; BRCA cis rs9790314 0.589 rs1447618 chr3:160610438 C/T cg03342759 chr3:160939853 NMD3 0.44 8.73 0.33 2.29e-17 Morning vs. evening chronotype; BRCA cis rs4363385 0.818 rs1415969 chr1:153006448 G/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.28 -0.34 2.53e-19 Inflammatory skin disease; BRCA cis rs7191700 0.578 rs243327 chr16:11353304 C/T cg00044050 chr16:11439710 C16orf75 -0.38 -8.89 -0.33 6.17e-18 Multiple sclerosis; BRCA cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg26597838 chr10:835615 NA -0.51 -9.68 -0.36 9.19e-21 Response to angiotensin II receptor blocker therapy; BRCA trans rs7395662 0.853 rs10838885 chr11:48398806 A/G cg00717180 chr2:96193071 NA -0.28 -7.82 -0.3 2.17e-14 HDL cholesterol; BRCA trans rs11722228 0.549 rs73212828 chr4:10078756 C/T cg26043149 chr18:55253948 FECH 1.08 22.94 0.67 2.05e-85 Gout;Urate levels;Serum uric acid levels; BRCA cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.93 0.33 4.51e-18 Motion sickness; BRCA cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.38 9.14 0.34 8.45e-19 Platelet count; BRCA cis rs875971 0.862 rs4718377 chr7:66049678 C/T cg11764359 chr7:65958608 NA -0.76 -16.7 -0.55 3.01e-52 Aortic root size; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.61 -0.32 5.51e-17 Total body bone mineral density; BRCA cis rs1580019 0.844 rs4723159 chr7:32512804 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.91 20.35 0.63 2.29e-71 Cognitive ability; BRCA cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg25358565 chr5:93447407 FAM172A 1.2 18.7 0.59 1.46e-62 Diabetic retinopathy; BRCA cis rs9649213 0.574 rs3801251 chr7:98027618 T/C cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 3.78e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs877282 0.898 rs11253343 chr10:765117 C/T cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.79 0.42 3.47e-29 Corneal astigmatism; BRCA trans rs3857536 0.730 rs7761295 chr6:66932532 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.08 -0.3 3.22e-15 Blood trace element (Cu levels); BRCA cis rs3892630 0.824 rs12327732 chr19:33221767 C/T cg22980127 chr19:33182716 NUDT19 0.9 17.65 0.57 4.12e-57 Red blood cell traits; BRCA cis rs875971 0.893 rs62465470 chr7:65601218 T/C cg11764359 chr7:65958608 NA -0.76 -17.22 -0.56 7.4e-55 Aortic root size; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.23 -0.68 4.97e-87 Gut microbiome composition (summer); BRCA cis rs7523273 0.565 rs1998538 chr1:207886487 C/T cg22525895 chr1:207977042 MIR29B2 -0.33 -7.82 -0.3 2.24e-14 Schizophrenia; BRCA cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg01416388 chr22:39784598 NA -0.38 -7.95 -0.3 8.4e-15 Intelligence (multi-trait analysis); BRCA cis rs17818399 1.000 rs17818399 chr2:46826026 A/C cg02822958 chr2:46747628 ATP6V1E2 0.5 9.94 0.37 1e-21 Height; BRCA cis rs847577 0.572 rs847573 chr7:97681761 C/T cg21770322 chr7:97807741 LMTK2 -0.4 -9.48 -0.35 4.96e-20 Breast cancer; BRCA cis rs999943 1.000 rs999943 chr6:33624733 A/G cg14003231 chr6:33640908 ITPR3 0.5 12.3 0.44 2.26e-31 Obesity (extreme); BRCA cis rs9467773 0.572 rs9467737 chr6:26381630 T/C cg09904177 chr6:26538194 HMGN4 -0.34 -8.84 -0.33 9.15e-18 Intelligence (multi-trait analysis); BRCA cis rs6840360 0.571 rs10026670 chr4:152539212 C/T cg22705602 chr4:152727874 NA -0.32 -8.35 -0.31 4.37e-16 Intelligence (multi-trait analysis); BRCA cis rs2599510 0.693 rs2754514 chr2:32788836 T/A cg02381751 chr2:32503542 YIPF4 0.49 10.14 0.37 1.66e-22 Interleukin-18 levels; BRCA cis rs4805272 0.626 rs12610050 chr19:29331324 A/T cg04546413 chr19:29218101 NA 0.47 9.71 0.36 6.99e-21 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7089973 0.604 rs7095816 chr10:116585109 T/C cg23260525 chr10:116636907 FAM160B1 0.3 7.9 0.3 1.18e-14 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs7809950 1.000 rs2066735 chr7:107188719 G/T cg23024343 chr7:107201750 COG5 -0.42 -9.67 -0.36 1.01e-20 Coronary artery disease; BRCA cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg06618935 chr21:46677482 NA -0.35 -7.85 -0.3 1.82e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs2262909 0.962 rs56369285 chr19:22267185 T/C cg17074339 chr11:11642133 GALNTL4 0.43 8.31 0.31 5.77e-16 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs490234 0.841 rs477813 chr9:128416874 C/T cg14078157 chr9:128172775 NA 0.35 8.38 0.31 3.36e-16 Mean arterial pressure; BRCA cis rs698813 0.851 rs786413 chr2:44702758 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 8.75 0.33 1.87e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs11105298 0.891 rs4842661 chr12:89930399 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -8.99 -0.34 2.74e-18 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg00750074 chr16:89608354 SPG7 -0.37 -10.01 -0.37 5.44e-22 Multiple myeloma (IgH translocation); BRCA cis rs8038465 0.592 rs58443257 chr15:73930707 A/T cg15420318 chr15:73925796 NPTN 0.41 8.83 0.33 1.04e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.04 0.43 3.01e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 1.000 rs17711825 chr2:24124578 A/G cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 9.02e-38 Lymphocyte counts; BRCA cis rs250677 0.522 rs2217638 chr5:148364355 A/G cg12140854 chr5:148520817 ABLIM3 0.41 8.41 0.32 2.64e-16 Breast cancer; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg03395511 chr6:291903 DUSP22 0.55 11.2 0.41 1.06e-26 Menopause (age at onset); BRCA cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg04317338 chr11:64019027 PLCB3 0.54 9.5 0.35 4.12e-20 Mean platelet volume; BRCA cis rs4409675 0.576 rs2295367 chr1:28224312 C/T cg23691781 chr1:28212827 C1orf38 0.34 11.21 0.41 9.29e-27 Corneal astigmatism; BRCA cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.03 0.37 4.23e-22 Bipolar disorder; BRCA cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg15782153 chr7:917662 C7orf20 0.4 9.74 0.36 5.26e-21 Perceived unattractiveness to mosquitoes; BRCA cis rs12367572 0.620 rs2643140 chr12:45418311 C/T cg04608330 chr12:45269318 NELL2 -0.38 -7.88 -0.3 1.42e-14 Gut microbiome composition (summer); BRCA cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg02187348 chr16:89574699 SPG7 0.37 8.56 0.32 8.72e-17 Multiple myeloma (IgH translocation); BRCA cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs72781680 0.716 rs6731314 chr2:24048338 C/T cg08917208 chr2:24149416 ATAD2B -0.59 -10.08 -0.37 2.87e-22 Lymphocyte counts; BRCA trans rs11098499 0.818 rs10008791 chr4:120431469 A/C cg25214090 chr10:38739885 LOC399744 0.55 12.23 0.44 4.59e-31 Corneal astigmatism; BRCA trans rs6582630 0.555 rs7305352 chr12:38473800 T/C cg06521331 chr12:34319734 NA -0.51 -9.31 -0.35 2.03e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg04234412 chr22:24373322 LOC391322 0.62 15.17 0.51 1.32e-44 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7412746 0.588 rs10305664 chr1:150839686 A/C cg18016565 chr1:150552671 MCL1 0.34 7.9 0.3 1.25e-14 Melanoma; BRCA cis rs2762353 0.603 rs9393670 chr6:25789061 A/G cg03264133 chr6:25882463 NA 0.39 8.45 0.32 2.01e-16 Blood metabolite levels; BRCA cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs1707322 0.717 rs1135812 chr1:46095272 T/C cg03146154 chr1:46216737 IPP 0.52 11.73 0.42 6.24e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11711311 0.955 rs12636240 chr3:113391282 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.39 9.98 0.37 6.67e-22 IgG glycosylation; BRCA cis rs2797160 1.000 rs6569435 chr6:125998186 T/C cg05901451 chr6:126070800 HEY2 -0.39 -9.47 -0.35 5.54e-20 Endometrial cancer; BRCA trans rs7647973 0.667 rs4241405 chr3:49642027 C/T cg21659725 chr3:3221576 CRBN -0.48 -8.4 -0.32 2.91e-16 Menarche (age at onset); BRCA cis rs2637266 0.935 rs2579727 chr10:78395497 A/C cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs758324 0.947 rs559971 chr5:131316164 A/G cg06307176 chr5:131281290 NA 0.5 9.84 0.36 2.25e-21 Alzheimer's disease in APOE e4- carriers; BRCA cis rs3008870 0.916 rs2025608 chr1:67422550 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.58 0.67 1.81e-83 Lymphocyte percentage of white cells; BRCA cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg23018236 chr17:30244563 NA -0.66 -9.97 -0.37 7.61e-22 Hip circumference adjusted for BMI; BRCA cis rs2599510 0.811 rs2754523 chr2:32837110 A/G cg02381751 chr2:32503542 YIPF4 0.42 8.34 0.31 4.61e-16 Interleukin-18 levels; BRCA cis rs1153858 1.000 rs66714503 chr15:45648038 G/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs61931739 0.534 rs1608912 chr12:34008574 C/T cg06521331 chr12:34319734 NA -0.57 -11.25 -0.41 6.58e-27 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs28616694 chr21:46674786 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.89 0.48 1.56e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs7772486 0.875 rs9322043 chr6:146352690 A/G cg23711669 chr6:146136114 FBXO30 0.75 17.26 0.56 4.26e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs6089829 0.925 rs6122086 chr20:61664528 T/C cg23505145 chr19:12996616 KLF1 0.56 12.64 0.45 7.56e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg24549020 chr5:56110836 MAP3K1 0.6 12.38 0.44 1.05e-31 Initial pursuit acceleration; BRCA cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg22676075 chr6:135203613 NA 0.46 8.99 0.34 2.72e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs3741151 0.773 rs73544711 chr11:73164870 T/A cg17517138 chr11:73019481 ARHGEF17 0.89 12.53 0.44 2.35e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs9560113 1.000 rs4773386 chr13:112180896 C/G cg10483660 chr13:112241077 NA 0.32 7.98 0.3 6.88e-15 Menarche (age at onset); BRCA trans rs4718428 1.000 rs12534637 chr7:66327654 G/C cg18876405 chr7:65276391 NA 0.47 10.17 0.37 1.29e-22 Corneal structure; BRCA cis rs7586879 1.000 rs6736711 chr2:25116456 C/T cg01884057 chr2:25150051 NA 0.33 8.24 0.31 9.61e-16 Body mass index; BRCA cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg22903657 chr4:1355424 KIAA1530 -0.36 -8.06 -0.3 3.74e-15 Obesity-related traits; BRCA cis rs17345786 0.861 rs11711808 chr3:101235101 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 11.68 0.42 1.04e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.679 rs2838860 chr21:46684904 A/G cg11663144 chr21:46675770 NA -0.47 -11.24 -0.41 7.12e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs311392 0.867 rs434952 chr8:55091998 C/T cg11783602 chr8:55087084 NA -0.31 -9.07 -0.34 1.49e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg25036284 chr2:26402008 FAM59B -0.89 -15.33 -0.52 2.09e-45 Gut microbiome composition (summer); BRCA cis rs9858542 0.953 rs9859556 chr3:49455986 G/T cg03060546 chr3:49711283 APEH -0.51 -10.04 -0.37 3.84e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs826838 0.585 rs12296822 chr12:38625829 A/T cg26384229 chr12:38710491 ALG10B -0.44 -10.14 -0.37 1.63e-22 Heart rate; BRCA cis rs12220238 1.000 rs10824128 chr10:76007903 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.49 8.03 0.3 4.84e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs9287719 0.967 rs2884233 chr2:10745303 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA trans rs3942852 0.955 rs1532754 chr11:48115279 A/T cg15704280 chr7:45808275 SEPT13 -0.48 -8.44 -0.32 2.15e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs9486719 1.000 rs12190507 chr6:96898265 T/G cg06623918 chr6:96969491 KIAA0776 -0.72 -12.94 -0.46 3.55e-34 Migraine;Coronary artery disease; BRCA cis rs10189230 0.967 rs1367241 chr2:222353413 G/A cg14652038 chr2:222343519 EPHA4 0.47 13.02 0.46 1.53e-34 Urate levels in lean individuals; BRCA trans rs11764590 0.715 rs55810445 chr7:2103739 C/T cg11693508 chr17:37793320 STARD3 0.5 8.73 0.33 2.25e-17 Neuroticism; BRCA cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.22 7.89 0.3 1.34e-14 Autism spectrum disorder or schizophrenia; BRCA trans rs208520 0.955 rs12202599 chr6:67001573 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 13.36 0.47 4.29e-36 Exhaled nitric oxide output; BRCA cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.83 -0.36 2.47e-21 Tonsillectomy; BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg22920501 chr2:26401640 FAM59B -0.92 -17.62 -0.57 6.42e-57 Gut microbiome composition (summer); BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg23285459 chr7:2802560 GNA12 -0.35 -8.41 -0.32 2.67e-16 Height; BRCA cis rs6942756 1.000 rs56026912 chr7:128913937 A/G cg02491457 chr7:128862824 NA -0.7 -13.6 -0.47 3.59e-37 White matter hyperintensity burden; BRCA trans rs57221529 0.709 rs72706611 chr5:561146 C/A cg11887960 chr12:57824829 NA 0.5 8.33 0.31 5e-16 Lung disease severity in cystic fibrosis; BRCA cis rs11690935 1.000 rs312918 chr2:172569587 C/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -32.4 -0.79 5.77e-137 Schizophrenia; BRCA cis rs921968 0.541 rs488767 chr2:219466860 G/T cg02176678 chr2:219576539 TTLL4 0.47 12.32 0.44 1.88e-31 Mean corpuscular hemoglobin concentration; BRCA trans rs561341 1.000 rs542132 chr17:30307193 A/T cg27661571 chr11:113659931 NA -0.7 -10.89 -0.4 1.93e-25 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.82e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs17685 0.712 rs7794454 chr7:75776010 A/G cg16489192 chr7:75678113 MDH2;STYXL1 0.37 8.37 0.31 3.64e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg03264133 chr6:25882463 NA -0.53 -11.93 -0.43 9.61e-30 Blood metabolite levels; BRCA cis rs3733585 0.699 rs6449158 chr4:9960459 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.43 -0.38 1.25e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg03146154 chr1:46216737 IPP 0.45 9.99 0.37 6.25e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2243480 0.901 rs313808 chr7:65499873 T/G cg18252515 chr7:66147081 NA -0.86 -12.42 -0.44 7.02e-32 Diabetic kidney disease; BRCA cis rs941873 0.805 rs876678 chr10:81111036 G/T cg09469691 chr10:81107165 PPIF 0.42 9.05 0.34 1.64e-18 Height; BRCA cis rs864745 0.653 rs1635853 chr7:28189549 A/C cg22892036 chr7:28189139 JAZF1 0.5 11.25 0.41 6.7e-27 Crohn's disease;Type 2 diabetes; BRCA cis rs757081 0.867 rs2521999 chr11:17333183 G/A cg15432903 chr11:17409602 KCNJ11 -0.54 -9.64 -0.36 1.27e-20 Systolic blood pressure; BRCA cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg01802117 chr1:53393560 SCP2 -0.36 -8.19 -0.31 1.39e-15 Monocyte count; BRCA cis rs7917772 0.582 rs10786696 chr10:104378134 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.29 0.49 2.11e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11190604 0.943 rs9420792 chr10:102258439 C/T cg07080220 chr10:102295463 HIF1AN 0.59 13.65 0.48 2.09e-37 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26314531 chr2:26401878 FAM59B -0.72 -11.88 -0.43 1.44e-29 Gut microbiome composition (summer); BRCA cis rs10751667 0.666 rs6597957 chr11:982294 T/A cg10932868 chr11:921992 NA 0.5 12.71 0.45 3.63e-33 Alzheimer's disease (late onset); BRCA cis rs13394619 0.936 rs9789414 chr2:11724684 A/G cg07314298 chr2:11723111 GREB1 -0.56 -12.44 -0.44 5.56e-32 Endometriosis; BRCA cis rs7618501 0.602 rs2526743 chr3:50115245 G/A cg24110177 chr3:50126178 RBM5 0.4 11.09 0.4 3.02e-26 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs7294300 chr12:38277359 C/A cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs1215050 0.791 rs1605259 chr4:98799732 T/C cg05340658 chr4:99064831 C4orf37 0.44 10.13 0.37 1.74e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.830 rs2114425 chr4:99023967 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.7e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7727544 0.505 rs721121 chr5:131406433 T/G cg14196790 chr5:131705035 SLC22A5 0.36 9.11 0.34 1.07e-18 Blood metabolite levels; BRCA cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -9.85 -0.36 2.01e-21 Developmental language disorder (linguistic errors); BRCA cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg23887609 chr12:130822674 PIWIL1 0.42 9.05 0.34 1.76e-18 Menopause (age at onset); BRCA cis rs4566357 0.615 rs4675140 chr2:227908665 C/T cg11843606 chr2:227700838 RHBDD1 -0.43 -9.5 -0.35 4.04e-20 Coronary artery disease; BRCA cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg00106254 chr7:1943704 MAD1L1 -0.38 -9.86 -0.36 1.98e-21 Bipolar disorder and schizophrenia; BRCA cis rs977987 0.806 rs4887818 chr16:75361995 T/C cg03315344 chr16:75512273 CHST6 0.53 12.24 0.44 4.48e-31 Dupuytren's disease; BRCA cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.67 -13.53 -0.47 7.3e-37 Chronic sinus infection; BRCA cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.16 0.4 1.49e-26 Electroencephalogram traits; BRCA cis rs7605378 1.000 rs2577852 chr2:200687248 C/T cg23649088 chr2:200775458 C2orf69 0.49 10.09 0.37 2.57e-22 Osteoporosis; BRCA cis rs2549003 1.000 rs7735073 chr5:131815357 G/A cg02551604 chr5:131831745 NA -0.39 -14.62 -0.5 5.71e-42 Asthma (sex interaction); BRCA cis rs965469 1.000 rs6037538 chr20:3282978 T/C cg25506879 chr20:3388711 C20orf194 -0.5 -9.84 -0.36 2.33e-21 IFN-related cytopenia; BRCA cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg26536863 chr7:158807979 LOC154822 0.37 8.62 0.32 5.39e-17 Facial morphology (factor 20); BRCA cis rs35110281 0.627 rs6518268 chr21:44967448 A/G cg04455712 chr21:45112962 RRP1B 0.38 9.79 0.36 3.5e-21 Mean corpuscular volume; BRCA cis rs11605275 1.000 rs78687006 chr11:20032176 G/A cg14835545 chr11:20032148 NAV2 -0.59 -9.36 -0.35 1.28e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2235642 0.928 rs2076435 chr16:1607574 C/T cg26528668 chr16:1614120 IFT140 0.37 8.35 0.31 4.16e-16 Coronary artery disease; BRCA cis rs10751667 1.000 rs7395691 chr11:985006 T/C cg06064525 chr11:970664 AP2A2 -0.32 -9.15 -0.34 7.28e-19 Alzheimer's disease (late onset); BRCA trans rs3960554 0.800 rs80002395 chr7:75814902 C/T cg19862616 chr7:65841803 NCRNA00174 0.58 11.91 0.43 1.15e-29 Eotaxin levels; BRCA cis rs2832077 0.943 rs11701445 chr21:30160807 C/T cg24692254 chr21:30365293 RNF160 -0.45 -8.03 -0.3 4.85e-15 Cognitive test performance; BRCA cis rs2153535 0.541 rs7774752 chr6:8468978 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs6500602 0.787 rs7204624 chr16:4459834 A/G cg08645402 chr16:4508243 NA 0.39 8.42 0.32 2.53e-16 Schizophrenia; BRCA cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.82 0.55 8.18e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6429082 0.702 rs10802797 chr1:235705673 A/G cg26050004 chr1:235667680 B3GALNT2 0.45 10.64 0.39 1.95e-24 Adiposity; BRCA cis rs9463078 0.605 rs4711799 chr6:44765780 A/T cg25276700 chr6:44698697 NA 0.37 8.65 0.32 4.1e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.65 12.94 0.46 3.43e-34 Lymphocyte counts; BRCA cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.01 -0.3 5.32e-15 Extrinsic epigenetic age acceleration; BRCA trans rs61931739 0.500 rs9705909 chr12:34576419 G/C cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 5.91e-52 Morning vs. evening chronotype; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg09256448 chr16:638327 NA 0.3 7.88 0.3 1.42e-14 Height; BRCA cis rs2354432 0.607 rs6683243 chr1:146733422 A/T cg25205988 chr1:146714368 CHD1L -0.95 -11.76 -0.42 5e-29 Mitochondrial DNA levels; BRCA trans rs61931739 0.890 rs1705748 chr12:34133171 A/G cg26384229 chr12:38710491 ALG10B 0.44 10.59 0.39 2.89e-24 Morning vs. evening chronotype; BRCA trans rs11088226 1.000 rs11088226 chr21:33925531 C/G cg09050820 chr6:167586206 TCP10L2 0.49 8.52 0.32 1.17e-16 Gastritis; BRCA cis rs6835098 0.692 rs7657374 chr4:174065756 A/T cg08422745 chr4:174089978 GALNT7 -0.58 -11.99 -0.43 5.12e-30 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs35146811 0.735 rs858512 chr7:99824453 A/G cg13334819 chr7:99746414 C7orf59 0.39 8.96 0.33 3.49e-18 Coronary artery disease; BRCA cis rs736408 0.716 rs2300149 chr3:52822921 C/T cg18404041 chr3:52824283 ITIH1 -0.5 -16.06 -0.54 4.97e-49 Bipolar disorder; BRCA cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg26248373 chr2:1572462 NA -0.45 -8.58 -0.32 7.23e-17 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7666738 0.830 rs1426664 chr4:98988264 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.64 0.39 1.81e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1005277 0.557 rs176887 chr10:38406094 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.81e-26 Extrinsic epigenetic age acceleration; BRCA cis rs7592578 0.882 rs16832765 chr2:191468762 T/C cg11845111 chr2:191398756 TMEM194B -0.81 -13.88 -0.48 1.73e-38 Diastolic blood pressure; BRCA cis rs6450176 0.909 rs6898870 chr5:53293107 G/A ch.5.1024479R chr5:53302184 ARL15 -0.59 -13.85 -0.48 2.33e-38 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs1577917 0.958 rs12213343 chr6:86443019 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.6 -0.45 1.15e-32 Response to antipsychotic treatment; BRCA cis rs13191362 0.935 rs66635391 chr6:162964577 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 7.97 0.3 7.13e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs9790314 0.747 rs9990115 chr3:160838412 C/G cg04691961 chr3:161091175 C3orf57 -0.46 -9.88 -0.36 1.65e-21 Morning vs. evening chronotype; BRCA cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg22601191 chr20:60968625 CABLES2 0.33 8.37 0.31 3.64e-16 Colorectal cancer; BRCA trans rs7824557 0.707 rs3808519 chr8:11142970 C/G cg08975724 chr8:8085496 FLJ10661 0.44 8.56 0.32 8.57e-17 Retinal vascular caliber; BRCA cis rs1707322 0.686 rs2991987 chr1:46081422 C/G cg06784218 chr1:46089804 CCDC17 -0.54 -13.26 -0.46 1.22e-35 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs736801 0.521 rs2070729 chr5:131819921 G/T cg21138405 chr5:131827807 IRF1 0.32 10.35 0.38 2.5e-23 Breast cancer;Mosquito bite size; BRCA cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg05347473 chr6:146136440 FBXO30 -0.61 -12.02 -0.43 3.63e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg23978390 chr7:1156363 C7orf50 0.4 7.84 0.3 1.91e-14 Bronchopulmonary dysplasia; BRCA cis rs801193 0.805 rs12532355 chr7:66070584 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -9.0 -0.34 2.61e-18 Aortic root size; BRCA cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.64 0.39 1.8e-24 Chronic sinus infection; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.1 0.64 2.26e-75 Gut microbiome composition (summer); BRCA cis rs727563 0.635 rs5751141 chr22:42107745 A/G cg03806693 chr22:41940476 POLR3H 0.9 15.34 0.52 1.91e-45 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg05863683 chr7:1912471 MAD1L1 0.4 8.44 0.32 2.1e-16 Bipolar disorder and schizophrenia; BRCA cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg07952391 chr2:88470173 THNSL2 0.67 9.09 0.34 1.27e-18 Plasma clusterin levels; BRCA cis rs6842047 0.520 rs4253425 chr4:187205929 T/C cg14349977 chr4:187219430 NA -0.6 -7.9 -0.3 1.25e-14 Blood protein levels; BRCA trans rs526821 0.553 rs519637 chr11:55295935 A/T cg11707556 chr5:10655725 ANKRD33B -0.37 -8.18 -0.31 1.53e-15 Pediatric bone mineral density (spine); BRCA cis rs10992471 0.603 rs1535755 chr9:95202031 G/T cg14631576 chr9:95140430 CENPP -0.39 -9.31 -0.35 2.09e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs1882538 0.538 rs7803848 chr7:133108547 C/T cg10665199 chr7:133106180 EXOC4 0.43 9.18 0.34 6.06e-19 Intelligence (multi-trait analysis); BRCA cis rs56114371 0.777 rs200482 chr6:27773904 G/A cg26587870 chr6:27730563 NA -0.51 -7.98 -0.3 6.71e-15 Breast cancer; BRCA cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 12.56 0.45 1.65e-32 Personality dimensions; BRCA cis rs754466 0.651 rs10824584 chr10:79625947 G/A cg17075019 chr10:79541650 NA -0.73 -17.59 -0.57 8.49e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg24675658 chr1:53192096 ZYG11B -0.66 -14.4 -0.5 6.14e-41 Monocyte count; BRCA cis rs7092929 0.883 rs705459 chr10:3615477 T/C cg14308648 chr10:3568949 NA 0.46 8.43 0.32 2.37e-16 Coronary artery calcification; BRCA cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs2522056 1.000 rs2706381 chr5:131810619 C/T cg24060327 chr5:131705240 SLC22A5 0.46 8.01 0.3 5.4e-15 Lymphocyte counts;Fibrinogen; BRCA cis rs9814567 1.000 rs6801596 chr3:134252114 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.52 -0.61 6.85e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs875971 0.862 rs6958294 chr7:65794796 C/A cg11764359 chr7:65958608 NA -0.76 -16.74 -0.55 1.98e-52 Aortic root size; BRCA cis rs561341 1.000 rs15654 chr17:30326360 A/C cg23018236 chr17:30244563 NA -0.64 -10.29 -0.38 4.42e-23 Hip circumference adjusted for BMI; BRCA cis rs7264396 0.563 rs6058296 chr20:34269225 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.69 -0.39 1.23e-24 Total cholesterol levels; BRCA cis rs17401966 0.964 rs6674843 chr1:10458378 A/T cg03954927 chr1:10346856 KIF1B 0.41 11.14 0.4 1.87e-26 Hepatocellular carcinoma; BRCA cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg26384229 chr12:38710491 ALG10B 0.68 15.78 0.53 1.36e-47 Drug-induced liver injury (flucloxacillin); BRCA trans rs10506458 0.834 rs73127067 chr12:63390333 G/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -19.08 -0.6 1.43e-64 Hemostatic factors and hematological phenotypes; BRCA cis rs801193 0.967 rs2707841 chr7:66157020 A/G cg11764359 chr7:65958608 NA 0.68 15.14 0.51 1.77e-44 Aortic root size; BRCA cis rs208520 0.779 rs208451 chr6:66906155 G/A cg07460842 chr6:66804631 NA -0.89 -15.26 -0.52 4.77e-45 Exhaled nitric oxide output; BRCA cis rs34172651 0.517 rs1465423 chr16:24772680 C/G cg06028605 chr16:24865363 SLC5A11 -0.45 -10.1 -0.37 2.28e-22 Intelligence (multi-trait analysis); BRCA cis rs3858526 1.000 rs3858527 chr11:5959848 G/A cg25319279 chr11:5960081 NA -0.39 -8.16 -0.31 1.79e-15 DNA methylation (variation); BRCA cis rs11098499 0.818 rs55825515 chr4:120486402 A/G cg09307838 chr4:120376055 NA 0.68 13.34 0.47 5.48e-36 Corneal astigmatism; BRCA cis rs6594499 0.872 rs6881147 chr5:110451936 G/C cg04022379 chr5:110408740 TSLP 0.35 7.92 0.3 1.09e-14 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7756236 0.521 rs9462209 chr6:36628042 T/G cg08179530 chr6:36648295 CDKN1A 0.37 7.95 0.3 8.38e-15 QRS duration; BRCA cis rs2479724 0.776 rs12523672 chr6:41749692 T/G cg17623882 chr6:41773611 USP49 0.32 8.56 0.32 8.48e-17 Menarche (age at onset); BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.71 -12.2 -0.43 6.19e-31 Platelet count; BRCA trans rs11098499 0.863 rs1155576 chr4:120450159 A/C cg25214090 chr10:38739885 LOC399744 0.51 11.78 0.42 4.18e-29 Corneal astigmatism; BRCA cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg11058730 chr11:34937778 PDHX;APIP 0.67 15.53 0.52 2.17e-46 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs16866061 1.000 rs72974267 chr2:225454209 T/C cg12698349 chr2:225449008 CUL3 0.77 20.78 0.63 1.21e-73 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg00106254 chr7:1943704 MAD1L1 -0.39 -9.6 -0.36 1.72e-20 Bipolar disorder and schizophrenia; BRCA cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.46 8.76 0.33 1.76e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08109568 chr15:31115862 NA 0.41 10.02 0.37 4.66e-22 Huntington's disease progression; BRCA cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg12311346 chr5:56204834 C5orf35 -0.82 -16.25 -0.54 5.79e-50 Initial pursuit acceleration; BRCA cis rs7592578 0.766 rs62182885 chr2:191437024 A/G cg10560079 chr2:191398806 TMEM194B -0.76 -12.98 -0.46 2.24e-34 Diastolic blood pressure; BRCA cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.4 -0.44 8.87e-32 Bipolar disorder; BRCA cis rs7766436 0.885 rs10946567 chr6:22581302 T/C cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA trans rs1005277 0.540 rs2474598 chr10:38430296 C/T cg23533926 chr12:111358616 MYL2 0.41 8.62 0.32 5.12e-17 Extrinsic epigenetic age acceleration; BRCA cis rs1348850 0.526 rs10803912 chr2:178407176 A/C cg23306229 chr2:178417860 TTC30B -0.46 -7.88 -0.3 1.4e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1904096 0.506 rs7439869 chr4:95173779 T/C cg11021082 chr4:95130006 SMARCAD1 -0.41 -8.51 -0.32 1.26e-16 Type 2 diabetes; BRCA cis rs6582630 0.560 rs12315134 chr12:38419857 T/A cg26384229 chr12:38710491 ALG10B -0.43 -9.82 -0.36 2.68e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg01283332 chr5:1856932 NA -0.35 -8.55 -0.32 9.33e-17 Cardiovascular disease risk factors; BRCA trans rs3749237 0.964 rs1799843 chr3:49849723 G/A cg21659725 chr3:3221576 CRBN 0.51 12.26 0.44 3.67e-31 Resting heart rate; BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg15673110 chr2:32581747 BIRC6 0.35 8.01 0.3 5.58e-15 Mosquito bite size; BRCA cis rs17401966 1.000 rs7520651 chr1:10329872 G/A cg03954927 chr1:10346856 KIF1B 0.45 13.16 0.46 3.76e-35 Hepatocellular carcinoma; BRCA cis rs9790314 1.000 rs3849524 chr3:161015589 C/T cg04691961 chr3:161091175 C3orf57 -0.59 -14.32 -0.49 1.53e-40 Morning vs. evening chronotype; BRCA cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg06634786 chr22:41940651 POLR3H 0.57 10.31 0.38 3.6e-23 Vitiligo; BRCA cis rs911119 0.818 rs67862677 chr20:23591086 A/C cg16589663 chr20:23618590 CST3 0.43 8.16 0.31 1.76e-15 Chronic kidney disease; BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.42 8.66 0.32 3.86e-17 Tonsillectomy; BRCA cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6545883 1.000 rs778763 chr2:61785639 C/G cg15711740 chr2:61764176 XPO1 -0.56 -14.18 -0.49 6.66e-40 Tuberculosis; BRCA cis rs11971779 0.680 rs10229249 chr7:139052510 A/T cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs600806 0.850 rs3879452 chr1:109929237 G/A cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg16482183 chr6:26056742 HIST1H1C 0.65 13.47 0.47 1.41e-36 Height; BRCA cis rs12431939 0.947 rs68180359 chr14:51672027 G/A cg23942311 chr14:51606299 NA -0.44 -8.09 -0.3 2.92e-15 Cancer; BRCA cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.37 0.54 1.48e-50 Smoking behavior; BRCA cis rs2153535 0.580 rs7755284 chr6:8457479 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs6733011 0.508 rs6542843 chr2:99533729 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.25 -0.34 3.37e-19 Bipolar disorder; BRCA cis rs701145 0.556 rs355787 chr3:153994502 T/C cg12800244 chr3:153838788 SGEF 0.44 8.91 0.33 5.1e-18 Coronary artery disease; BRCA cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg25427524 chr10:38739819 LOC399744 0.69 16.75 0.55 1.84e-52 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs8114671 0.647 rs6060267 chr20:33734012 A/G cg24642439 chr20:33292090 TP53INP2 0.4 8.6 0.32 5.93e-17 Height; BRCA cis rs9399135 0.967 rs9373122 chr6:135373534 G/A cg24558204 chr6:135376177 HBS1L 0.45 12.34 0.44 1.6e-31 Red blood cell count; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg09256448 chr16:638327 NA 0.3 7.81 0.3 2.43e-14 Height; BRCA cis rs13108904 0.935 rs1732102 chr4:1277924 T/C cg00684032 chr4:1343700 KIAA1530 -0.3 -7.86 -0.3 1.68e-14 Obesity-related traits; BRCA cis rs9790314 0.875 rs336568 chr3:161072763 G/C cg03342759 chr3:160939853 NMD3 -0.55 -12.07 -0.43 2.26e-30 Morning vs. evening chronotype; BRCA cis rs701145 0.585 rs1470663 chr3:153870883 A/G cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs9462027 0.628 rs9469889 chr6:34763900 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.04 -0.34 1.8e-18 Total body bone mineral density; BRCA cis rs1707322 1.000 rs1707317 chr1:46510642 C/T cg03146154 chr1:46216737 IPP -0.47 -10.32 -0.38 3.43e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs61931739 0.500 rs9705909 chr12:34576419 G/C cg06521331 chr12:34319734 NA -0.55 -9.94 -0.37 9.47e-22 Morning vs. evening chronotype; BRCA cis rs67478160 0.643 rs8005225 chr14:104300151 C/T cg01849466 chr14:104193079 ZFYVE21 0.43 11.06 0.4 3.72e-26 Schizophrenia; BRCA cis rs1008375 0.932 rs6841784 chr4:17626418 G/A cg04450456 chr4:17643702 FAM184B 0.35 9.64 0.36 1.22e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9420 0.961 rs12804972 chr11:57463767 T/C cg19752551 chr11:57585705 CTNND1 -0.51 -12.52 -0.44 2.44e-32 Schizophrenia; BRCA cis rs4595586 0.545 rs12809206 chr12:39388748 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.44 0.35 6.82e-20 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.7 0.61 6.89e-68 Platelet count; BRCA cis rs611744 0.647 rs702808 chr8:109252554 T/C cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs965469 0.901 rs7270135 chr20:3247922 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -10.73 -0.39 7.94e-25 IFN-related cytopenia; BRCA cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg11890956 chr21:40555474 PSMG1 0.94 22.75 0.67 2.32e-84 Cognitive function; BRCA cis rs36051895 0.632 rs10974983 chr9:5149657 G/T cg02405213 chr9:5042618 JAK2 -0.46 -8.58 -0.32 7.2e-17 Pediatric autoimmune diseases; BRCA cis rs12310956 0.532 rs6488186 chr12:33974122 G/A cg06521331 chr12:34319734 NA -0.57 -11.13 -0.4 2.03e-26 Morning vs. evening chronotype; BRCA cis rs4664304 0.802 rs1511224 chr2:160750861 C/T cg01092293 chr2:160761427 LY75 -0.34 -7.87 -0.3 1.57e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7312933 0.618 rs12366848 chr12:42682215 A/G cg01256987 chr12:42539512 GXYLT1 -0.4 -7.86 -0.3 1.59e-14 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg13271783 chr10:134563150 INPP5A -0.44 -9.18 -0.34 6.01e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg00409905 chr10:38381863 ZNF37A -0.48 -9.95 -0.37 9.11e-22 Extrinsic epigenetic age acceleration; BRCA cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg24531977 chr5:56204891 C5orf35 -0.81 -16.77 -0.55 1.38e-52 Initial pursuit acceleration; BRCA cis rs7020830 0.867 rs7852593 chr9:37332380 A/T cg14294708 chr9:37120828 ZCCHC7 1.14 37.96 0.83 6.2e-166 Schizophrenia; BRCA cis rs6570726 0.935 rs408768 chr6:145871735 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.85 0.51 4.51e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.77 21.35 0.65 1e-76 Multiple sclerosis; BRCA trans rs3942852 0.774 rs2270990 chr11:48184983 G/T cg03929089 chr4:120376271 NA -0.48 -9.09 -0.34 1.28e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs1401999 0.724 rs1016752 chr3:183665062 C/G cg01324343 chr3:183735012 ABCC5 -0.75 -15.99 -0.53 1.2e-48 Anterior chamber depth; BRCA trans rs8062405 1.000 rs62036617 chr16:28827498 T/C cg09719594 chr16:21412588 NA -0.32 -7.92 -0.3 1.05e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg11764359 chr7:65958608 NA 0.76 16.79 0.55 1.17e-52 Aortic root size; BRCA trans rs17685 0.712 rs7778735 chr7:75770237 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9880211 0.706 rs67382287 chr3:136380459 C/T cg21827317 chr3:136751795 NA -0.45 -8.03 -0.3 4.75e-15 Body mass index;Height; BRCA cis rs96067 0.805 rs1033890 chr1:36608414 C/T cg24686825 chr1:36642396 MAP7D1 -0.5 -8.93 -0.33 4.6e-18 Corneal structure; BRCA cis rs12549902 0.897 rs12549294 chr8:41506380 A/G cg21772509 chr8:41503840 NKX6-3 0.49 11.36 0.41 2.27e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg13628971 chr7:2884303 GNA12 0.4 9.16 0.34 6.76e-19 Height; BRCA cis rs6942756 1.000 rs9640854 chr7:128884057 A/T cg02491457 chr7:128862824 NA -0.72 -13.95 -0.48 8.27e-39 White matter hyperintensity burden; BRCA cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg06191203 chr2:152266755 RIF1 0.36 10.75 0.39 7.06e-25 Lung cancer; BRCA cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg11663144 chr21:46675770 NA -0.52 -12.11 -0.43 1.57e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9646954 0.542 rs3828193 chr2:101031561 A/C cg08017756 chr2:100939284 LONRF2 0.31 8.01 0.3 5.51e-15 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.818 rs572821 chr1:153008276 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.8 -0.33 1.3e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs9733 0.596 rs7538493 chr1:150655421 T/C cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg03433033 chr1:76189801 ACADM 0.57 11.59 0.42 2.44e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9291683 0.530 rs998675 chr4:9948829 A/G cg11266682 chr4:10021025 SLC2A9 0.41 11.02 0.4 5.59e-26 Bone mineral density; BRCA cis rs7949030 0.626 rs7943191 chr11:62328551 A/G cg13298116 chr11:62369859 EML3;MTA2 0.57 13.79 0.48 4.61e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7824557 0.527 rs2409756 chr8:11242025 A/C cg21775007 chr8:11205619 TDH -0.53 -11.52 -0.41 5.11e-28 Retinal vascular caliber; BRCA cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg23277830 chr1:3704460 LRRC47 0.26 7.97 0.3 7.22e-15 Red cell distribution width; BRCA cis rs6598955 0.543 rs6690461 chr1:26543097 T/A cg04990556 chr1:26633338 UBXN11 0.71 11.98 0.43 5.76e-30 Obesity-related traits; BRCA cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg04553112 chr3:125709451 NA -0.56 -8.44 -0.32 2.07e-16 Blood pressure (smoking interaction); BRCA cis rs6570726 0.905 rs375692 chr6:145840368 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.0 0.51 8.96e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg11707556 chr5:10655725 ANKRD33B -0.41 -8.97 -0.33 3.23e-18 Coronary artery disease; BRCA cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg11189052 chr15:85197271 WDR73 -0.33 -7.81 -0.3 2.35e-14 P wave terminal force; BRCA cis rs875971 0.545 rs221986 chr7:65570310 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.48 -0.38 8.16e-24 Aortic root size; BRCA cis rs4780401 0.782 rs933573 chr16:11793395 A/G cg01061890 chr16:11836724 TXNDC11 0.36 7.96 0.3 7.65e-15 Rheumatoid arthritis; BRCA cis rs1997103 1.000 rs1997102 chr7:55399322 A/C cg17469321 chr7:55412551 NA -0.5 -9.29 -0.34 2.46e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg00420348 chr11:830190 EFCAB4A -0.49 -10.58 -0.39 3.16e-24 Mean platelet volume; BRCA cis rs7246657 0.882 rs59224125 chr19:37963205 T/C cg18154014 chr19:37997991 ZNF793 0.48 9.57 0.35 2.23e-20 Coronary artery calcification; BRCA cis rs8114671 0.773 rs3746438 chr20:33584289 C/T cg07148914 chr20:33460835 GGT7 -0.38 -8.12 -0.31 2.47e-15 Height; BRCA trans rs1005277 0.579 rs2505248 chr10:38459097 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.78e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6840360 0.593 rs1429558 chr4:152685406 A/T cg22705602 chr4:152727874 NA -0.38 -10.39 -0.38 1.81e-23 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg04267008 chr7:1944627 MAD1L1 -0.51 -11.52 -0.41 4.77e-28 Bipolar disorder and schizophrenia; BRCA cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg18404041 chr3:52824283 ITIH1 0.43 12.04 0.43 3.23e-30 Bipolar disorder; BRCA cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg13770153 chr20:60521292 NA -0.38 -9.01 -0.34 2.37e-18 Body mass index; BRCA cis rs523522 0.962 rs2233676 chr12:120933607 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.51e-36 High light scatter reticulocyte count; BRCA cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg10523679 chr1:76189770 ACADM 0.91 26.56 0.72 2.59e-105 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2243480 1.000 rs1715235 chr7:65488394 T/C cg18252515 chr7:66147081 NA -0.88 -12.64 -0.45 7.81e-33 Diabetic kidney disease; BRCA trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA trans rs7829975 0.624 rs7823056 chr8:8382705 A/G cg16141378 chr3:129829833 LOC729375 -0.32 -8.1 -0.31 2.8e-15 Mood instability; BRCA cis rs7098414 0.511 rs10887826 chr10:82151380 C/T cg01528321 chr10:82214614 TSPAN14 0.68 14.62 0.5 5.85e-42 Post bronchodilator FEV1; BRCA cis rs9649213 0.593 rs3801263 chr7:97965016 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.81 0.42 2.89e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA trans rs7746199 0.736 rs34064842 chr6:27688625 G/T cg06606381 chr12:133084897 FBRSL1 -0.87 -8.9 -0.33 5.82e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg19847866 chr10:1019161 NA -0.52 -10.64 -0.39 1.9e-24 Response to angiotensin II receptor blocker therapy; BRCA cis rs2882667 0.858 rs10900856 chr5:138417746 C/T cg04439458 chr5:138467593 SIL1 0.44 11.11 0.4 2.43e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.48e-61 Cognitive function; BRCA cis rs7246657 0.943 rs10415937 chr19:37830064 T/G cg23950597 chr19:37808831 NA -0.62 -11.33 -0.41 2.99e-27 Coronary artery calcification; BRCA cis rs34779708 0.966 rs2045918 chr10:35418517 T/G cg03585969 chr10:35415529 CREM 0.55 11.37 0.41 2.17e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg22906224 chr7:99728672 NA 0.45 8.65 0.32 4.11e-17 Coronary artery disease; BRCA cis rs7208859 0.623 rs7503335 chr17:29073962 G/A cg13385521 chr17:29058706 SUZ12P 0.77 12.06 0.43 2.56e-30 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs57221529 0.766 rs4245972 chr5:578572 A/G cg08313168 chr12:7315531 NA 0.5 8.09 0.3 2.95e-15 Lung disease severity in cystic fibrosis; BRCA cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.29 9.53 0.35 3.08e-20 Bipolar disorder; BRCA cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.59 9.68 0.36 8.68e-21 Renal function-related traits (BUN); BRCA cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg07414643 chr4:187882934 NA 0.28 9.65 0.36 1.2e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs2289583 0.503 rs12050494 chr15:75260896 G/A cg14664628 chr15:75095509 CSK 0.5 10.62 0.39 2.23e-24 Systemic lupus erythematosus; BRCA cis rs10883723 0.738 rs3781290 chr10:104244948 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.84 0.6 2.52e-63 Allergic disease (asthma, hay fever or eczema); BRCA cis rs13191362 0.810 rs13209784 chr6:162961274 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.85 0.45 8.5e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs10752881 1.000 rs12403189 chr1:182983832 G/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.41e-52 Colorectal cancer; BRCA cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg05985134 chr18:33552581 C18orf21 0.71 13.62 0.47 2.99e-37 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs34172651 0.917 rs17771137 chr16:24792242 G/A cg04756594 chr16:24857601 SLC5A11 0.34 8.35 0.31 4.09e-16 Intelligence (multi-trait analysis); BRCA cis rs912057 0.965 rs1294415 chr6:6740633 G/A cg06612196 chr6:6737390 NA 0.44 9.48 0.35 5.04e-20 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg21782813 chr7:2030301 MAD1L1 0.3 7.86 0.3 1.58e-14 Autism spectrum disorder or schizophrenia; BRCA trans rs9951602 0.512 rs58352488 chr18:76651113 T/A cg02800362 chr5:177631904 HNRNPAB 0.77 18.01 0.58 5.8e-59 Obesity-related traits; BRCA cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.7 18.21 0.58 5.62e-60 Electrocardiographic conduction measures; BRCA cis rs12367572 0.965 rs1506678 chr12:45249492 A/G cg04608330 chr12:45269318 NELL2 -0.62 -14.07 -0.49 2.23e-39 Gut microbiome composition (summer); BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -11.38 -0.41 1.89e-27 Alzheimer's disease; BRCA cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.83 0.62 1.53e-68 Cognitive function; BRCA trans rs2739330 0.789 rs5760109 chr22:24252938 C/G cg06437703 chr8:37914619 EIF4EBP1 -0.33 -8.78 -0.33 1.47e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.53 -0.35 3.35e-20 Endometrial cancer; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.57 10.18 0.37 1.13e-22 Gut microbiome composition (summer); BRCA cis rs9325144 0.532 rs12812406 chr12:38719802 G/A cg13010199 chr12:38710504 ALG10B -0.36 -7.95 -0.3 8.19e-15 Morning vs. evening chronotype; BRCA cis rs7086627 0.515 rs11202960 chr10:82209807 G/A cg01528321 chr10:82214614 TSPAN14 0.62 14.12 0.49 1.3e-39 Post bronchodilator FEV1; BRCA cis rs881375 0.678 rs10760129 chr9:123700183 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.56 12.01 0.43 4.02e-30 Rheumatoid arthritis; BRCA cis rs765787 0.530 rs11636440 chr15:45535982 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.51 -0.41 5.45e-28 Uric acid levels; BRCA cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg11952622 chr19:58962976 ZNF324B 0.43 8.7 0.33 2.77e-17 Uric acid clearance; BRCA cis rs4423214 0.840 rs1790328 chr11:71148038 G/A cg05163923 chr11:71159392 DHCR7 -0.54 -10.94 -0.4 1.22e-25 Vitamin D levels; BRCA cis rs9462027 0.651 rs34493158 chr6:34753339 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.04 -0.3 4.28e-15 Systemic lupus erythematosus; BRCA cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg07636037 chr3:49044803 WDR6 0.97 28.28 0.75 1.07e-114 Parkinson's disease; BRCA cis rs3820928 0.839 rs35068645 chr2:227844265 T/C cg11843606 chr2:227700838 RHBDD1 -0.37 -8.33 -0.31 4.85e-16 Pulmonary function; BRCA trans rs35110281 0.744 rs162398 chr21:44949285 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.05 0.3 4.02e-15 Mean corpuscular volume; BRCA cis rs738322 0.533 rs5756934 chr22:38547279 G/A cg20207973 chr22:38506712 BAIAP2L2 0.35 8.57 0.32 7.5e-17 Cutaneous nevi; BRCA cis rs739401 0.566 rs7931504 chr11:3026712 C/T cg05729581 chr11:3078854 CARS -0.36 -8.8 -0.33 1.31e-17 Longevity; BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg19346786 chr7:2764209 NA 0.35 10.64 0.39 1.94e-24 Height; BRCA cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg07148914 chr20:33460835 GGT7 0.38 8.63 0.32 4.77e-17 Height; BRCA cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.54 16.69 0.55 3.59e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 13.48 0.47 1.27e-36 Colorectal cancer; BRCA cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg02475777 chr4:1388615 CRIPAK -0.48 -9.49 -0.35 4.57e-20 Obesity-related traits; BRCA cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg18876405 chr7:65276391 NA 0.47 10.57 0.39 3.65e-24 Aortic root size; BRCA cis rs2663905 0.706 rs2683260 chr15:81385552 A/C cg09888468 chr15:81410853 NA -0.46 -7.94 -0.3 9.02e-15 QT interval (drug interaction); BRCA cis rs1865721 0.958 rs57073257 chr18:73172316 A/G cg26385618 chr18:73139727 C18orf62 -0.39 -9.03 -0.34 1.94e-18 Intelligence; BRCA cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -13.16 -0.46 3.63e-35 Chronic sinus infection; BRCA cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg16405210 chr4:1374714 KIAA1530 0.67 13.87 0.48 1.95e-38 Obesity-related traits; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg03923535 chr7:1197113 ZFAND2A 0.48 9.44 0.35 6.7e-20 Longevity;Endometriosis; BRCA cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 7.15e-87 Chronic sinus infection; BRCA cis rs4268898 0.662 rs72795824 chr2:24435837 T/C cg06627628 chr2:24431161 ITSN2 -0.85 -15.66 -0.53 5.08e-47 Asthma; BRCA cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.39 -8.16 -0.31 1.77e-15 Alzheimer's disease (late onset); BRCA cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg11764359 chr7:65958608 NA 0.67 14.95 0.51 1.49e-43 Aortic root size; BRCA cis rs17253792 0.822 rs76557162 chr14:56064701 A/G cg01858014 chr14:56050164 KTN1 -0.77 -10.93 -0.4 1.3e-25 Putamen volume; BRCA cis rs36051895 0.695 rs59384377 chr9:5005034 A/T cg02405213 chr9:5042618 JAK2 -0.51 -9.1 -0.34 1.16e-18 Pediatric autoimmune diseases; BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.89 0.33 6.31e-18 Tonsillectomy; BRCA cis rs1577917 0.917 rs35283633 chr6:86690787 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.28 -0.46 1.06e-35 Response to antipsychotic treatment; BRCA cis rs6831352 0.918 rs13112176 chr4:100055825 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs72781680 0.898 rs17763224 chr2:24213776 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs3806843 1.000 rs3756339 chr5:140180537 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.82e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs595982 0.527 rs17206707 chr19:49361441 A/C cg15549821 chr19:49342101 PLEKHA4 -0.69 -11.12 -0.4 2.28e-26 Red cell distribution width; BRCA cis rs651907 0.535 rs11716558 chr3:101528481 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.47 0.5 2.98e-41 Colorectal cancer; BRCA cis rs9788682 0.747 rs16969894 chr15:78776456 C/T cg24631222 chr15:78858424 CHRNA5 0.49 9.54 0.35 2.94e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg02574844 chr11:5959923 NA -0.39 -8.17 -0.31 1.61e-15 DNA methylation (variation); BRCA cis rs12579753 0.917 rs7972839 chr12:82178920 C/T cg07988820 chr12:82153109 PPFIA2 -0.46 -8.17 -0.31 1.67e-15 Resting heart rate; BRCA cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.85 -0.36 2.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs7301016 0.846 rs11174568 chr12:63021157 T/C cg01804193 chr12:63026212 NA 0.47 8.41 0.32 2.73e-16 IgG glycosylation; BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg00814883 chr7:100076585 TSC22D4 -0.47 -10.43 -0.38 1.3e-23 Platelet count; BRCA cis rs757081 0.667 rs34724588 chr11:17137581 T/C cg15432903 chr11:17409602 KCNJ11 -0.46 -8.62 -0.32 5.29e-17 Systolic blood pressure; BRCA cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs10267417 0.603 rs4721829 chr7:19873199 A/G cg07541023 chr7:19748670 TWISTNB 0.47 8.45 0.32 2.01e-16 Night sleep phenotypes; BRCA cis rs7602441 0.521 rs1434985 chr2:14767916 C/T cg06545361 chr2:14773388 FAM84A 0.62 8.46 0.32 1.77e-16 Visceral adipose tissue adjusted for BMI; BRCA cis rs9837602 0.938 rs1017968 chr3:99787011 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.33 0.41 2.91e-27 Breast cancer; BRCA cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg07395648 chr5:131743802 NA 0.37 8.71 0.33 2.51e-17 Breast cancer;Mosquito bite size; BRCA cis rs13046373 0.535 rs2832970 chr21:32020767 T/C cg16431978 chr21:31797932 KRTAP13-3 0.35 8.98 0.33 3.03e-18 HDL cholesterol; BRCA cis rs7020830 0.825 rs13297152 chr9:37075623 C/T cg14294708 chr9:37120828 ZCCHC7 1.16 35.4 0.81 9.39e-153 Schizophrenia; BRCA cis rs34172651 0.917 rs7202252 chr16:24741686 T/C cg04756594 chr16:24857601 SLC5A11 -0.36 -8.69 -0.32 3.14e-17 Intelligence (multi-trait analysis); BRCA cis rs6450176 1.000 rs3776716 chr5:53298923 A/G ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs11098499 0.954 rs10024844 chr4:120311528 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs9790314 0.601 rs1450519 chr3:161094930 A/G cg03342759 chr3:160939853 NMD3 -0.54 -11.92 -0.43 1.04e-29 Morning vs. evening chronotype; BRCA cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg25767906 chr1:53392781 SCP2 0.38 8.71 0.33 2.68e-17 Monocyte count; BRCA cis rs514406 0.708 rs480299 chr1:53320274 G/T cg27535305 chr1:53392650 SCP2 -0.5 -12.2 -0.43 6.56e-31 Monocyte count; BRCA cis rs1707322 0.721 rs61784800 chr1:46178112 A/G cg06784218 chr1:46089804 CCDC17 -0.49 -11.61 -0.42 2.08e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg16431978 chr21:31797932 KRTAP13-3 0.37 9.22 0.34 4.39e-19 HDL cholesterol; BRCA cis rs2991971 0.933 rs2356553 chr1:46009313 G/C cg24296786 chr1:45957014 TESK2 0.58 14.22 0.49 4.48e-40 High light scatter reticulocyte count; BRCA cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg06108461 chr20:60628389 TAF4 -0.82 -17.59 -0.57 8.54e-57 Body mass index; BRCA cis rs1865760 0.963 rs1540273 chr6:25924158 T/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.46 0.38 9.53e-24 Height; BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg12444411 chr7:2802554 GNA12 -0.35 -8.48 -0.32 1.6e-16 Height; BRCA cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.87 0.39 2.36e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.72 0.36 6.33e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg27170947 chr2:26402098 FAM59B -0.64 -10.93 -0.4 1.29e-25 Gut microbiome composition (summer); BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg22920501 chr2:26401640 FAM59B -0.67 -11.56 -0.42 3.5e-28 Gut microbiome composition (summer); BRCA cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg05868516 chr6:26286170 HIST1H4H 0.42 8.17 0.31 1.6e-15 Educational attainment; BRCA cis rs9296092 0.517 rs56069946 chr6:33511136 G/A cg13560919 chr6:33536144 NA -0.86 -16.21 -0.54 9.71e-50 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs6910061 0.957 rs58680949 chr6:11103062 G/C cg27233058 chr6:11094804 LOC221710 0.52 9.32 0.35 1.82e-19 Diabetic kidney disease; BRCA cis rs586533 0.846 rs687007 chr11:99511801 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.88 0.3 1.44e-14 Depressive symptoms (multi-trait analysis); BRCA trans rs9467711 0.606 rs13212985 chr6:26609989 G/C cg01620082 chr3:125678407 NA -0.69 -8.59 -0.32 6.67e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.57 -10.18 -0.37 1.13e-22 Gut microbiome composition (summer); BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.57 8.41 0.32 2.63e-16 Cerebrospinal P-tau181p levels; BRCA cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg24531977 chr5:56204891 C5orf35 0.67 14.6 0.5 7.34e-42 Initial pursuit acceleration; BRCA cis rs9341808 0.690 rs9343970 chr6:80881289 C/G cg08355045 chr6:80787529 NA 0.38 9.71 0.36 7.25e-21 Sitting height ratio; BRCA cis rs2576037 0.526 rs4258717 chr18:44456954 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 8.63 0.32 4.98e-17 Personality dimensions; BRCA cis rs7659604 0.702 rs6815790 chr4:122695385 A/C cg20573242 chr4:122745356 CCNA2 0.43 9.92 0.37 1.18e-21 Type 2 diabetes; BRCA cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg10802521 chr3:52805072 NEK4 -0.3 -8.0 -0.3 5.78e-15 Electroencephalogram traits; BRCA trans rs35110281 0.774 rs1003280 chr21:44997322 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.23 0.31 1.06e-15 Mean corpuscular volume; BRCA cis rs4845875 0.530 rs4846048 chr1:11846252 A/G cg24844545 chr1:11908347 NPPA -0.36 -8.58 -0.32 7.06e-17 Midregional pro atrial natriuretic peptide levels; BRCA trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg15704280 chr7:45808275 SEPT13 0.63 11.24 0.41 6.97e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs60843830 1.000 rs62114505 chr2:242426 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.82 18.86 0.6 2.17e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.23 -0.31 1.06e-15 Bipolar disorder; BRCA cis rs9287719 0.967 rs4284804 chr2:10722124 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.07 -0.3 3.48e-15 Prostate cancer; BRCA cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg02551604 chr5:131831745 NA -0.4 -14.94 -0.51 1.6e-43 Asthma (sex interaction); BRCA cis rs709400 0.628 rs2273699 chr14:103923475 A/G cg24130564 chr14:104152367 KLC1 -0.34 -7.92 -0.3 1.02e-14 Body mass index; BRCA cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -16.12 -0.54 2.63e-49 Extrinsic epigenetic age acceleration; BRCA cis rs780094 0.544 rs780108 chr2:27684957 T/C cg17158414 chr2:27665306 KRTCAP3 -0.31 -8.04 -0.3 4.32e-15 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg20503657 chr10:835505 NA 1.3 21.17 0.64 8.88e-76 Eosinophil percentage of granulocytes; BRCA cis rs10045504 0.502 rs10512692 chr5:38762993 G/A cg15396434 chr5:38725168 NA -0.53 -10.19 -0.37 1.09e-22 Night sleep phenotypes; BRCA cis rs1267303 0.642 rs3737740 chr1:47000596 G/A cg25110126 chr1:46999211 NA 0.72 13.57 0.47 4.84e-37 Monobrow; BRCA cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg12219531 chr12:120966889 COQ5 0.56 11.7 0.42 8.42e-29 High light scatter reticulocyte count; BRCA cis rs10751667 0.600 rs10902264 chr11:1003523 G/A ch.11.42038R chr11:967971 AP2A2 0.46 13.79 0.48 4.83e-38 Alzheimer's disease (late onset); BRCA cis rs1800795 0.652 rs7802307 chr7:22766433 T/A cg26061582 chr7:22766209 IL6 0.42 9.44 0.35 6.71e-20 Cerebrospinal fluid clusterin levels in APOEe4- carriers; BRCA cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg12641515 chr19:46296257 DMWD 0.69 16.87 0.56 4.48e-53 Coronary artery disease; BRCA cis rs6460942 0.597 rs17545416 chr7:12525944 A/T cg06484146 chr7:12443880 VWDE -0.6 -7.85 -0.3 1.8e-14 Coronary artery disease; BRCA cis rs4919087 1.000 rs10882898 chr10:99087330 G/A cg25902810 chr10:99078978 FRAT1 -0.45 -9.37 -0.35 1.2e-19 Monocyte count; BRCA cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg18876405 chr7:65276391 NA -0.55 -13.3 -0.47 8.39e-36 Aortic root size; BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00149659 chr3:10157352 C3orf10 0.76 12.99 0.46 2.1e-34 Alzheimer's disease; BRCA cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg19678392 chr7:94953810 PON1 -0.42 -8.58 -0.32 7.29e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6815814 0.950 rs5743595 chr4:38802644 A/G cg02016764 chr4:38805732 TLR1 -0.63 -10.03 -0.37 4.28e-22 Breast cancer; BRCA cis rs829661 0.947 rs829665 chr2:30724701 T/A cg17749961 chr2:30669863 LCLAT1 1.12 14.83 0.51 5.9e-43 Midgestational circulating levels of PBDEs (fetal genetic effect); BRCA cis rs701145 0.938 rs355776 chr3:154035626 A/T cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs7666738 0.719 rs35184673 chr4:99050945 T/C cg17366294 chr4:99064904 C4orf37 0.47 8.16 0.31 1.79e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.722 rs10409605 chr19:38123137 T/G cg14683738 chr19:37701593 ZNF585B 0.47 8.11 0.31 2.51e-15 Coronary artery calcification; BRCA cis rs61931739 0.500 rs7306334 chr12:34482900 A/G cg06521331 chr12:34319734 NA 0.53 9.81 0.36 2.93e-21 Morning vs. evening chronotype; BRCA cis rs144345632 1 rs144345632 chr6:96886894 T/TA cg06623918 chr6:96969491 KIAA0776 -0.72 -12.99 -0.46 2.13e-34 Facial morphology (factor 17, height of vermillion upper lip); BRCA cis rs10927875 0.526 rs2179615 chr1:16282426 G/A cg21385522 chr1:16154831 NA -0.85 -15.3 -0.52 3.03e-45 Dilated cardiomyopathy; BRCA cis rs78487399 0.908 rs76765584 chr2:43808034 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.9 -0.3 1.22e-14 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs875971 0.862 rs801195 chr7:66026115 A/G cg18876405 chr7:65276391 NA -0.5 -11.04 -0.4 4.74e-26 Aortic root size; BRCA cis rs9309711 0.666 rs6723126 chr2:3484500 T/C cg15541040 chr2:3486749 NA -0.46 -10.23 -0.38 7.58e-23 Neurofibrillary tangles; BRCA trans rs911555 0.692 rs7146215 chr14:103915908 A/G cg17675199 chr6:35436792 RPL10A -0.3 -7.92 -0.3 1.05e-14 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.943 rs10405407 chr19:37839164 C/T cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg11266682 chr4:10021025 SLC2A9 0.47 12.68 0.45 5e-33 Bone mineral density; BRCA cis rs9462027 0.628 rs2764197 chr6:34705055 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA cis rs1577917 0.740 rs2842614 chr6:86306069 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.76 -0.33 1.71e-17 Response to antipsychotic treatment; BRCA cis rs7772486 0.875 rs7766463 chr6:146364453 A/G cg23711669 chr6:146136114 FBXO30 0.69 16.02 0.54 8.15e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs4481887 0.962 rs5009868 chr1:248474495 A/G cg00666640 chr1:248458726 OR2T12 0.34 9.09 0.34 1.23e-18 Common traits (Other); BRCA cis rs911119 1.000 rs3088162 chr20:23607752 C/A cg16589663 chr20:23618590 CST3 0.46 8.91 0.33 5.45e-18 Chronic kidney disease; BRCA cis rs17092148 0.945 rs6060042 chr20:33361721 A/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.3 -0.41 4.05e-27 Neuroticism; BRCA cis rs61931739 0.534 rs1352206 chr12:34036668 G/A cg06521331 chr12:34319734 NA -0.63 -12.2 -0.43 6.34e-31 Morning vs. evening chronotype; BRCA cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg24562669 chr7:97807699 LMTK2 -0.49 -13.0 -0.46 1.94e-34 Breast cancer; BRCA cis rs312274 0.569 rs10879356 chr12:41312365 A/T cg17827154 chr12:41323612 CNTN1 -0.42 -10.63 -0.39 2.04e-24 Metabolite levels (X-11787); BRCA cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg06221963 chr1:154839813 KCNN3 -0.57 -16.22 -0.54 8.16e-50 Prostate cancer; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg15112475 chr7:1198522 ZFAND2A -0.42 -9.13 -0.34 8.69e-19 Longevity;Endometriosis; BRCA cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg27535305 chr1:53392650 SCP2 0.49 11.32 0.41 3.5e-27 Monocyte count; BRCA cis rs9612 0.948 rs12609056 chr19:44258702 G/T cg08581076 chr19:44259116 C19orf61 0.53 9.34 0.35 1.59e-19 Exhaled nitric oxide output; BRCA cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg06917634 chr15:78832804 PSMA4 0.76 17.82 0.58 5.48e-58 Sudden cardiac arrest; BRCA cis rs9392556 0.829 rs634698 chr6:4114247 T/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -8.13 -0.31 2.28e-15 Blood metabolite levels; BRCA cis rs4363385 0.818 rs2651413 chr1:153012068 T/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.67 0.5 3.23e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs220324 0.688 rs9980786 chr21:43562535 C/T cg09727148 chr21:43560719 UMODL1 0.48 8.4 0.32 2.81e-16 Idiopathic osteonecrosis of the femoral head; BRCA cis rs763014 1.000 rs7205409 chr16:642610 A/G cg07343612 chr16:622815 PIGQ -0.65 -21.24 -0.64 3.63e-76 Height; BRCA cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03517284 chr6:25882590 NA -0.37 -7.89 -0.3 1.35e-14 Intelligence (multi-trait analysis); BRCA trans rs3960554 0.808 rs61303167 chr7:75671175 G/T cg19862616 chr7:65841803 NCRNA00174 0.59 12.53 0.44 2.26e-32 Eotaxin levels; BRCA cis rs10782582 0.532 rs78106188 chr1:76137836 A/G cg10523679 chr1:76189770 ACADM -0.48 -9.2 -0.34 5.21e-19 Daytime sleep phenotypes; BRCA cis rs9287719 0.967 rs3814388 chr2:10702099 A/T cg00105475 chr2:10696890 NA 0.44 10.21 0.37 9.03e-23 Prostate cancer; BRCA cis rs4919694 1.000 rs11191439 chr10:104638723 C/T cg04362960 chr10:104952993 NT5C2 -0.92 -14.57 -0.5 9.68e-42 Arsenic metabolism; BRCA cis rs9287719 0.967 rs6432112 chr2:10744874 A/G cg00105475 chr2:10696890 NA -0.45 -10.4 -0.38 1.61e-23 Prostate cancer; BRCA cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg05340658 chr4:99064831 C4orf37 0.61 14.49 0.5 2.44e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs59724122 0.542 rs28633173 chr8:27446980 A/G cg01579299 chr8:27450062 NA 0.47 8.91 0.33 5.46e-18 Bipolar disorder lithium response (categorical) or schizophrenia; BRCA cis rs9868809 0.772 rs2302295 chr3:48690110 T/C cg00383909 chr3:49044727 WDR6 0.53 9.44 0.35 6.62e-20 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs826838 0.616 rs10880751 chr12:38627485 C/T cg26384229 chr12:38710491 ALG10B 0.44 10.09 0.37 2.68e-22 Heart rate; BRCA cis rs1113500 0.897 rs11185263 chr1:108639804 C/G cg06207961 chr1:108661230 NA 0.43 11.02 0.4 5.69e-26 Growth-regulated protein alpha levels; BRCA cis rs7584330 0.666 rs60671275 chr2:238374318 C/A cg14458575 chr2:238380390 NA 0.75 16.29 0.54 3.59e-50 Prostate cancer; BRCA cis rs72781680 0.898 rs111460347 chr2:24018833 G/A cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs757081 0.702 rs522619 chr11:17204448 A/G cg15432903 chr11:17409602 KCNJ11 -0.45 -8.51 -0.32 1.23e-16 Systolic blood pressure; BRCA cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.55 -0.39 4.16e-24 Mean corpuscular volume; BRCA cis rs9399137 0.507 rs6918512 chr6:135284839 T/G cg22676075 chr6:135203613 NA 0.44 8.7 0.33 2.91e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.27 0.31 7.99e-16 Mean platelet volume; BRCA cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg20701182 chr2:24300061 SF3B14 0.58 9.05 0.34 1.73e-18 Lymphocyte counts; BRCA cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 15.12 0.51 2.22e-44 Colorectal cancer; BRCA cis rs6545883 0.929 rs6705235 chr2:61713580 G/C cg15711740 chr2:61764176 XPO1 -0.55 -14.0 -0.48 5.14e-39 Tuberculosis; BRCA cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg03146154 chr1:46216737 IPP 0.49 10.66 0.39 1.61e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6866344 0.697 rs62392833 chr5:178135452 T/A cg10224037 chr5:178157518 ZNF354A 0.75 15.63 0.53 7.51e-47 Neutrophil percentage of white cells; BRCA cis rs6964587 0.967 rs6465340 chr7:91588664 G/A cg01689657 chr7:91764605 CYP51A1 0.21 7.83 0.3 2.04e-14 Breast cancer; BRCA cis rs7737355 0.947 rs42264 chr5:130810028 T/G cg06307176 chr5:131281290 NA 0.53 10.41 0.38 1.45e-23 Life satisfaction; BRCA cis rs1568889 1.000 rs1568889 chr11:28009463 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.7 13.23 0.46 1.69e-35 Bipolar disorder; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg03188948 chr7:1209495 NA 0.61 12.08 0.43 2e-30 Longevity;Endometriosis; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg18402987 chr7:1209562 NA 0.64 13.99 0.48 5.5e-39 Longevity;Endometriosis; BRCA cis rs586533 0.881 rs611253 chr11:99505250 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2806561 0.796 rs1738467 chr1:23506521 C/T cg12483005 chr1:23474871 LUZP1 0.46 10.22 0.37 8.4e-23 Height; BRCA cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg17420585 chr12:42539391 GXYLT1 -0.38 -7.96 -0.3 8.03e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs35110281 0.667 rs7282405 chr21:45123611 C/G cg21573476 chr21:45109991 RRP1B -0.4 -10.48 -0.38 7.94e-24 Mean corpuscular volume; BRCA cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.4 0.35 9.69e-20 Body mass index; BRCA trans rs6600671 1.000 rs11249350 chr1:121178446 C/T cg17023122 chr1:144479586 NA 0.33 7.85 0.3 1.71e-14 Hip geometry; BRCA cis rs9443645 0.509 rs9361459 chr6:79572922 A/G cg05283184 chr6:79620031 NA 0.34 8.51 0.32 1.2e-16 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg24562669 chr7:97807699 LMTK2 0.47 12.78 0.45 1.9e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg18225595 chr11:63971243 STIP1 0.5 8.89 0.33 6.02e-18 Mean platelet volume; BRCA cis rs4363385 0.747 rs2339491 chr1:152985322 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.29 -0.31 6.7e-16 Inflammatory skin disease; BRCA cis rs2730245 0.569 rs1188955 chr7:158690866 A/G cg17136484 chr7:158649327 WDR60 0.38 8.13 0.31 2.29e-15 Height; BRCA cis rs1669338 0.588 rs3931974 chr3:3186894 A/G cg16797762 chr3:3221439 CRBN 0.55 8.65 0.32 4.02e-17 White matter integrity; BRCA cis rs13392177 0.660 rs62185964 chr2:219073745 A/G cg00012203 chr2:219082015 ARPC2 -0.51 -10.46 -0.38 9.84e-24 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.65 16.6 0.55 9.95e-52 Colorectal cancer; BRCA cis rs6908034 0.660 rs12525506 chr6:19794234 G/T cg02682789 chr6:19804855 NA 0.76 9.23 0.34 4.06e-19 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; BRCA cis rs9811920 0.609 rs793447 chr3:99598278 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs9527 0.615 rs3897401 chr10:104696379 T/C cg04362960 chr10:104952993 NT5C2 0.45 10.43 0.38 1.31e-23 Arsenic metabolism; BRCA cis rs7666738 0.753 rs4699604 chr4:99056353 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.82 0.39 3.53e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12681288 0.578 rs10503154 chr8:969343 C/G cg04851639 chr8:1020857 NA -0.35 -9.53 -0.35 3.3e-20 Schizophrenia; BRCA cis rs7395581 0.918 rs326214 chr11:47298360 G/A cg25783544 chr11:47291846 MADD -0.39 -8.78 -0.33 1.48e-17 HDL cholesterol; BRCA cis rs10504229 0.639 rs16921812 chr8:58106737 C/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg23978390 chr7:1156363 C7orf50 0.41 8.07 0.3 3.52e-15 Bronchopulmonary dysplasia; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg04025307 chr7:1156635 C7orf50 0.58 9.14 0.34 8.42e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12292205 chr6:26970375 C6orf41 -0.48 -8.07 -0.3 3.56e-15 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.505 rs1208689 chr10:38097775 C/G cg25427524 chr10:38739819 LOC399744 -0.66 -16.24 -0.54 6.88e-50 Extrinsic epigenetic age acceleration; BRCA cis rs17767294 0.708 rs79956881 chr6:28030150 T/C cg08851530 chr6:28072375 NA 1.18 10.76 0.39 6.47e-25 Parkinson's disease; BRCA cis rs7267979 0.903 rs6132819 chr20:25218618 C/G cg08601574 chr20:25228251 PYGB 0.42 9.84 0.36 2.31e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg08132940 chr7:1081526 C7orf50 -0.53 -8.29 -0.31 6.8e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6594499 0.843 rs1993465 chr5:110433098 A/G cg04022379 chr5:110408740 TSLP 0.35 7.88 0.3 1.44e-14 Allergic disease (asthma, hay fever or eczema); BRCA cis rs920590 0.758 rs7012358 chr8:19662498 C/T cg03894339 chr8:19674705 INTS10 0.43 8.21 0.31 1.18e-15 Acute lymphoblastic leukemia (childhood); BRCA trans rs11165623 0.564 rs12752866 chr1:97000181 T/C cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.11e-30 Hip circumference;Waist circumference; BRCA cis rs1267303 0.537 rs59935547 chr1:47001423 A/G cg25110126 chr1:46999211 NA 0.56 10.72 0.39 9.03e-25 Monobrow; BRCA cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg18230493 chr5:56204884 C5orf35 -0.62 -13.19 -0.46 2.68e-35 Initial pursuit acceleration; BRCA cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg02734326 chr4:10020555 SLC2A9 0.36 7.81 0.3 2.37e-14 Bone mineral density; BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg11814155 chr7:99998594 ZCWPW1 0.43 8.1 0.31 2.75e-15 Platelet count; BRCA trans rs6011368 0.840 rs6062361 chr20:62904542 C/T cg13869341 chr1:15865 WASH5P -0.41 -9.31 -0.35 2.09e-19 Clozapine-induced cytotoxicity; BRCA cis rs4076764 0.881 rs10917758 chr1:163430652 G/A cg24596788 chr1:163392923 NA -0.34 -8.97 -0.33 3.26e-18 Motion sickness; BRCA cis rs7666738 0.830 rs3852123 chr4:98697586 A/G cg05340658 chr4:99064831 C4orf37 0.63 15.01 0.51 7.95e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg08213375 chr14:104286397 PPP1R13B 0.64 18.3 0.59 1.85e-60 Schizophrenia; BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg14004847 chr7:1930337 MAD1L1 -0.43 -8.71 -0.33 2.6e-17 Bipolar disorder and schizophrenia; BRCA cis rs912057 0.932 rs1294404 chr6:6735022 G/A cg06612196 chr6:6737390 NA 0.46 9.94 0.37 9.34e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs1008375 0.866 rs2109518 chr4:17572162 G/A cg15017067 chr4:17643749 FAM184B 0.34 10.56 0.39 3.74e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7572733 0.534 rs4550664 chr2:198691405 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.14 0.37 1.65e-22 Dermatomyositis; BRCA cis rs6840360 0.533 rs1397683 chr4:152715916 T/C cg22705602 chr4:152727874 NA 0.4 10.58 0.39 3.36e-24 Intelligence (multi-trait analysis); BRCA cis rs4631830 0.863 rs57263518 chr10:51519154 A/G cg20129853 chr10:51489980 NA -0.29 -7.93 -0.3 1.01e-14 Prostate-specific antigen levels; BRCA cis rs11711311 1.000 rs9811200 chr3:113531180 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.41 10.55 0.39 4.26e-24 IgG glycosylation; BRCA cis rs2880765 0.714 rs6497187 chr15:86011350 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.39 -0.31 3.16e-16 Coronary artery disease; BRCA cis rs4919087 0.962 rs3740522 chr10:99019144 C/T cg25902810 chr10:99078978 FRAT1 0.44 9.23 0.34 3.76e-19 Monocyte count; BRCA cis rs7481584 0.624 rs436580 chr11:3063961 T/G cg08508325 chr11:3079039 CARS 0.29 8.98 0.33 2.93e-18 Calcium levels; BRCA cis rs990171 0.506 rs2041748 chr2:102756295 A/G cg22835712 chr2:102737379 NA 0.6 11.3 0.41 3.97e-27 Lymphocyte counts; BRCA cis rs6089584 0.627 rs13045575 chr20:60565596 G/A cg06108461 chr20:60628389 TAF4 -0.64 -13.18 -0.46 2.7900000000000003e-35 Body mass index; BRCA cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11644478 chr21:40555479 PSMG1 0.5 10.74 0.39 7.39e-25 Menarche (age at onset); BRCA cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg08280861 chr8:58055591 NA 0.53 8.59 0.32 6.62e-17 Developmental language disorder (linguistic errors); BRCA cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg15017067 chr4:17643749 FAM184B 0.32 9.79 0.36 3.53e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs401166 chr20:25446308 C/G cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3096299 0.658 rs4291902 chr16:89560315 G/C cg02187348 chr16:89574699 SPG7 0.5 11.97 0.43 6.11e-30 Multiple myeloma (IgH translocation); BRCA trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.95 0.3 8.6e-15 Corneal astigmatism; BRCA cis rs6867032 0.958 rs4975798 chr5:2015580 G/A cg26168224 chr5:2018326 NA 0.63 17.48 0.57 3.28e-56 Gut microbiome composition (winter); BRCA cis rs34779708 0.733 rs3853672 chr10:35549606 A/C cg03585969 chr10:35415529 CREM 0.43 8.64 0.32 4.64e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3806843 0.897 rs2531338 chr5:140136957 A/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.37 0.35 1.18e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs61931739 0.517 rs11052977 chr12:34035030 A/C cg06521331 chr12:34319734 NA -0.62 -11.15 -0.4 1.68e-26 Morning vs. evening chronotype; BRCA cis rs9296092 0.538 rs9461875 chr6:33516644 C/T cg13560919 chr6:33536144 NA -0.83 -16.87 -0.56 4.55e-53 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs911555 0.755 rs8014800 chr14:103946302 T/C cg12935359 chr14:103987150 CKB 0.64 15.0 0.51 8.63e-44 Intelligence (multi-trait analysis); BRCA cis rs3008870 0.755 rs2755242 chr1:67479598 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.66 0.48 1.83e-37 Lymphocyte percentage of white cells; BRCA trans rs208520 0.837 rs208498 chr6:66931560 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.81 -15.18 -0.51 1.12e-44 Exhaled nitric oxide output; BRCA cis rs6834538 0.597 rs9307383 chr4:113529834 C/T cg05166686 chr4:113558556 LARP7;C4orf21 0.42 9.75 0.36 4.99e-21 Free thyroxine concentration; BRCA cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg01483505 chr11:975446 AP2A2 0.31 8.3 0.31 6.1e-16 Alzheimer's disease (late onset); BRCA cis rs74181299 0.819 rs2252867 chr2:65296280 T/C cg05010058 chr2:65284262 CEP68 0.3 8.35 0.31 4.15e-16 Pulse pressure; BRCA cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs13095912 1.000 rs13072061 chr3:185326023 G/T cg11274856 chr3:185301563 NA 0.34 8.56 0.32 8.33e-17 Systolic blood pressure; BRCA cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.36 0.38 2.39e-23 Motion sickness; BRCA cis rs7568458 0.846 rs6547621 chr2:85774676 G/A cg17127132 chr2:85788382 GGCX 0.35 8.0 0.3 5.72e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9325144 0.555 rs28738714 chr12:38706912 G/A cg13010199 chr12:38710504 ALG10B -0.37 -8.41 -0.32 2.59e-16 Morning vs. evening chronotype; BRCA cis rs7149337 1.000 rs4261445 chr14:51723540 G/A cg23942311 chr14:51606299 NA 0.36 9.76 0.36 4.47e-21 Cancer; BRCA cis rs12410462 0.901 rs79626242 chr1:227650385 A/G cg04117972 chr1:227635322 NA 0.52 9.21 0.34 4.5e-19 Major depressive disorder; BRCA trans rs3780486 0.846 rs4584234 chr9:33147479 G/A cg20290983 chr6:43655470 MRPS18A 1.06 35.82 0.82 5.79e-155 IgG glycosylation; BRCA cis rs4664304 0.658 rs2667008 chr2:160865095 C/T cg14819504 chr2:160761413 LY75 -0.33 -8.08 -0.3 3.25e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.49 -0.32 1.47e-16 Total body bone mineral density; BRCA cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.12 -0.58 1.55e-59 Extrinsic epigenetic age acceleration; BRCA cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg07636037 chr3:49044803 WDR6 0.99 29.87 0.76 2.35e-123 Parkinson's disease; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg26608667 chr7:1196370 ZFAND2A 0.44 10.69 0.39 1.17e-24 Longevity;Endometriosis; BRCA cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg08885076 chr2:99613938 TSGA10 0.42 9.88 0.36 1.61e-21 Chronic sinus infection; BRCA cis rs6912958 0.781 rs2300906 chr6:88207155 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -8.81 -0.33 1.15e-17 Monocyte percentage of white cells; BRCA cis rs7020830 0.830 rs12554976 chr9:37244505 G/T cg14294708 chr9:37120828 ZCCHC7 1.13 36.23 0.82 4.69e-157 Schizophrenia; BRCA cis rs6433895 1.000 rs7592486 chr2:182013263 A/G cg00481216 chr2:181971175 NA 0.37 8.72 0.33 2.49e-17 Lymphocyte counts; BRCA cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg18904891 chr8:8559673 CLDN23 0.64 12.54 0.44 2.06e-32 Obesity-related traits; BRCA cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg25358565 chr5:93447407 FAM172A 1.17 18.19 0.58 6.98e-60 Diabetic retinopathy; BRCA trans rs9409565 0.826 rs9409767 chr9:97228524 T/C cg05679027 chr9:99775184 HIATL2 -0.43 -9.59 -0.35 1.8899999999999998e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs9487051 0.872 rs1521908 chr6:109613986 T/C cg21918786 chr6:109611834 NA -0.49 -13.85 -0.48 2.47e-38 Reticulocyte fraction of red cells; BRCA cis rs11098499 0.738 rs10026493 chr4:120384194 C/G cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.78 21.34 0.65 1.05e-76 Multiple sclerosis; BRCA cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg04546413 chr19:29218101 NA 0.64 12.28 0.44 2.81e-31 Methadone dose in opioid dependence; BRCA cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg09658497 chr7:2847517 GNA12 -0.4 -8.54 -0.32 1.01e-16 Height; BRCA cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg11812906 chr14:75593930 NEK9 0.66 15.33 0.52 2.05e-45 Height; BRCA trans rs1005277 0.522 rs1208767 chr10:38042295 G/T cg17830980 chr10:43048298 ZNF37B -0.41 -9.62 -0.36 1.55e-20 Extrinsic epigenetic age acceleration; BRCA cis rs250677 0.522 rs6872172 chr5:148359529 G/C cg18129178 chr5:148520854 ABLIM3 0.54 10.41 0.38 1.57e-23 Breast cancer; BRCA cis rs870825 0.616 rs6825561 chr4:185615532 A/T cg04058563 chr4:185651563 MLF1IP 0.78 17.17 0.56 1.32e-54 Blood protein levels; BRCA cis rs2806561 0.765 rs679591 chr1:23499916 T/C cg12483005 chr1:23474871 LUZP1 0.47 10.36 0.38 2.36e-23 Height; BRCA cis rs12579753 0.917 rs10862375 chr12:82254809 C/G cg07988820 chr12:82153109 PPFIA2 0.49 8.3 0.31 6.04e-16 Resting heart rate; BRCA cis rs16866061 0.926 rs1523919 chr2:225403615 G/A cg12698349 chr2:225449008 CUL3 0.75 17.89 0.58 2.44e-58 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7772486 0.875 rs9322048 chr6:146400439 A/G cg23711669 chr6:146136114 FBXO30 0.66 15.61 0.53 9.32e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg03264133 chr6:25882463 NA -0.34 -7.86 -0.3 1.61e-14 Intelligence (multi-trait analysis); BRCA cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.93 0.53 2.27e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9399135 0.660 rs4646868 chr6:135271946 A/G cg24558204 chr6:135376177 HBS1L 0.49 13.38 0.47 3.61e-36 Red blood cell count; BRCA cis rs60871478 1.000 rs4720930 chr7:808073 G/A cg04727924 chr7:799746 HEATR2 -0.53 -9.88 -0.36 1.6e-21 Cerebrospinal P-tau181p levels; BRCA trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg00717180 chr2:96193071 NA -0.4 -11.13 -0.4 2.1e-26 HDL cholesterol; BRCA cis rs6121246 0.609 rs6087783 chr20:30421224 T/G cg13852791 chr20:30311386 BCL2L1 0.87 19.45 0.61 1.48e-66 Mean corpuscular hemoglobin; BRCA cis rs9486719 1.000 rs10457159 chr6:96993139 G/A cg06623918 chr6:96969491 KIAA0776 -0.78 -14.16 -0.49 8.73e-40 Migraine;Coronary artery disease; BRCA cis rs9660992 0.762 rs1668871 chr1:205237137 T/C cg21545522 chr1:205238299 TMCC2 0.37 8.24 0.31 9.57e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg26314531 chr2:26401878 FAM59B 0.88 15.47 0.52 4.57e-46 Gut microbiome composition (summer); BRCA cis rs4711336 1.000 rs4711337 chr6:33659987 T/C cg14003231 chr6:33640908 ITPR3 0.32 7.88 0.3 1.41e-14 Height; BRCA cis rs9649465 0.934 rs718781 chr7:123313573 T/C cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.53e-16 Migraine; BRCA cis rs5753618 0.504 rs5753659 chr22:31893613 A/G cg02404636 chr22:31891804 SFI1 0.43 8.81 0.33 1.21e-17 Colorectal cancer; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg07092213 chr7:1199455 ZFAND2A -0.55 -12.35 -0.44 1.44e-31 Longevity;Endometriosis; BRCA cis rs6424115 0.867 rs11588187 chr1:24145047 T/A cg15997130 chr1:24165203 NA 0.49 12.86 0.45 7.62e-34 Immature fraction of reticulocytes; BRCA trans rs2262909 1.000 rs2359821 chr19:22208314 C/T cg17074339 chr11:11642133 GALNTL4 -0.41 -7.86 -0.3 1.64e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs7267979 0.966 rs6037097 chr20:25347221 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.27 0.34 2.88e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9359856 0.510 rs4053618 chr6:90459454 G/A cg13799429 chr6:90582589 CASP8AP2 0.72 10.96 0.4 9.94e-26 Bipolar disorder; BRCA cis rs4953076 0.533 rs1551315 chr2:44407618 G/A cg04920474 chr2:44395004 PPM1B 0.51 10.57 0.39 3.42e-24 Height; BRCA cis rs35146811 0.806 rs1534310 chr7:99699169 A/T cg13334819 chr7:99746414 C7orf59 -0.42 -9.93 -0.37 1.08e-21 Coronary artery disease; BRCA cis rs9291683 0.668 rs2241474 chr4:10086015 T/C cg02734326 chr4:10020555 SLC2A9 0.38 8.31 0.31 5.94e-16 Bone mineral density; BRCA cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg15212455 chr7:39170539 POU6F2 0.45 9.94 0.37 9.44e-22 IgG glycosylation; BRCA cis rs6752107 1.000 rs12994971 chr2:234178453 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.52 11.43 0.41 1.16e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs8072100 0.713 rs11079776 chr17:45546893 C/T cg08085267 chr17:45401833 C17orf57 -0.59 -12.19 -0.43 7.29e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2832077 0.943 rs2832099 chr21:30173460 A/G cg08807101 chr21:30365312 RNF160 -0.46 -8.15 -0.31 1.85e-15 Cognitive test performance; BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg24549020 chr5:56110836 MAP3K1 0.65 13.23 0.46 1.79e-35 Initial pursuit acceleration; BRCA cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.33 0.49 1.33e-40 Colorectal cancer; BRCA cis rs9486719 1.000 rs2472888 chr6:96865501 T/C cg06623918 chr6:96969491 KIAA0776 0.74 13.11 0.46 5.89e-35 Migraine;Coronary artery disease; BRCA cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg22009923 chr11:832065 CD151 -0.48 -10.32 -0.38 3.37e-23 Mean platelet volume; BRCA cis rs4363385 0.747 rs9919276 chr1:152968654 A/T cg24667326 chr1:152973720 SPRR3 -0.33 -8.98 -0.33 3.03e-18 Inflammatory skin disease; BRCA cis rs9443645 0.901 rs3805747 chr6:79672522 A/G cg05283184 chr6:79620031 NA -0.4 -10.25 -0.38 6.42e-23 Intelligence (multi-trait analysis); BRCA cis rs4285028 0.898 rs4305455 chr3:121619774 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.62 -11.28 -0.41 4.74e-27 Multiple sclerosis; BRCA cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg03477792 chr4:77819574 ANKRD56 0.66 15.67 0.53 4.35e-47 Emphysema distribution in smoking; BRCA cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg02038168 chr22:39784481 NA -0.42 -8.73 -0.33 2.24e-17 Intelligence (multi-trait analysis); BRCA cis rs34891900 0.507 rs5992088 chr22:18135912 C/T cg19898043 chr22:18121309 BCL2L13 -0.43 -8.36 -0.31 3.9e-16 Sum neutrophil eosinophil counts; BRCA cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg11789530 chr4:8429930 ACOX3 0.69 18.11 0.58 1.73e-59 Response to antineoplastic agents; BRCA trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 3.77e-39 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs921968 0.528 rs35695178 chr2:219589164 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 9.26e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs514406 0.929 rs554301 chr1:53321948 A/T cg01802117 chr1:53393560 SCP2 0.36 8.48 0.32 1.54e-16 Monocyte count; BRCA cis rs2422052 0.527 rs12466517 chr2:118830391 C/A cg22545206 chr2:118617499 NA -0.33 -8.01 -0.3 5.3e-15 Mosquito bite size; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.31 -0.44 2.07e-31 Lymphocyte counts; BRCA cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg20887711 chr4:1340912 KIAA1530 0.4 8.82 0.33 1.05e-17 Obesity-related traits; BRCA cis rs8070463 0.515 rs11655943 chr17:45385640 A/G cg25173405 chr17:45401733 C17orf57 -0.53 -11.33 -0.41 3.05e-27 Multiple sclerosis;Ankylosing spondylitis; BRCA cis rs2075371 0.933 rs1833474 chr7:133958240 A/G cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.42e-68 Mean platelet volume; BRCA cis rs2075371 1.000 rs378358 chr7:133970628 A/G cg02659138 chr7:134003124 SLC35B4 0.32 10.0 0.37 5.94e-22 Mean platelet volume; BRCA cis rs1577917 0.917 rs4098044 chr6:86462066 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.63 -0.45 8.57e-33 Response to antipsychotic treatment; BRCA trans rs961253 0.501 rs6054183 chr20:6354161 T/C cg21095983 chr6:86352623 SYNCRIP 0.39 7.97 0.3 7.23e-15 Colorectal cancer; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 14.05 0.49 2.93e-39 Lymphocyte counts; BRCA cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg12011299 chr4:100065546 ADH4 0.45 10.43 0.38 1.22e-23 Alcohol dependence; BRCA cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg24130564 chr14:104152367 KLC1 -0.39 -8.8 -0.33 1.28e-17 Intelligence (multi-trait analysis); BRCA cis rs7493 0.755 rs2375001 chr7:94964640 A/T cg17330251 chr7:94953956 PON1 -0.4 -8.3 -0.31 6.29e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs11051970 0.879 rs2088806 chr12:32592125 C/T cg02745156 chr12:32552066 NA 0.27 8.87 0.33 7.3e-18 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs629535 0.911 rs627382 chr8:70014081 C/T cg21567404 chr3:27674614 NA -0.98 -20.59 -0.63 1.24e-72 Dupuytren's disease; BRCA cis rs910316 0.763 rs175044 chr14:75472109 G/A cg08847533 chr14:75593920 NEK9 -0.78 -18.54 -0.59 9.57e-62 Height; BRCA cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.61e-27 Extrinsic epigenetic age acceleration; BRCA cis rs6840360 0.571 rs11940881 chr4:152501050 C/G cg25486957 chr4:152246857 NA -0.36 -7.95 -0.3 8.18e-15 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs1622208 chr1:46498375 A/G cg06784218 chr1:46089804 CCDC17 -0.48 -11.48 -0.41 7.5e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11051970 0.879 rs2243815 chr12:32576158 C/T cg02745156 chr12:32552066 NA 0.27 8.99 0.33 2.86e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11190604 1.000 rs1054399 chr10:102312565 C/T cg07080220 chr10:102295463 HIF1AN 0.6 13.95 0.48 8.71e-39 Palmitoleic acid (16:1n-7) levels; BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.41 8.41 0.32 2.62e-16 Tonsillectomy; BRCA cis rs7615952 0.599 rs6766327 chr3:125723677 C/G cg06494592 chr3:125709126 NA -0.53 -8.31 -0.31 5.63e-16 Blood pressure (smoking interaction); BRCA cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg06636001 chr8:8085503 FLJ10661 0.69 16.69 0.55 3.49e-52 Mood instability; BRCA cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA cis rs10911232 0.507 rs4397624 chr1:183053131 C/T ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.71e-54 Hypertriglyceridemia; BRCA cis rs6598955 0.671 rs17257176 chr1:26578233 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA trans rs35110281 0.782 rs2246602 chr21:45064296 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.32 0.35 1.92e-19 Mean corpuscular volume; BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg22920501 chr2:26401640 FAM59B -0.72 -12.35 -0.44 1.44e-31 Gut microbiome composition (summer); BRCA trans rs7786808 0.649 rs1377374 chr7:158215647 G/T cg02030672 chr11:45687055 CHST1 -0.41 -9.29 -0.34 2.48e-19 Obesity-related traits; BRCA cis rs3936840 0.548 rs1190545 chr14:102904179 G/C cg18135206 chr14:102964638 TECPR2 -0.47 -9.27 -0.34 2.76e-19 Plateletcrit; BRCA cis rs78456975 0.506 rs13402886 chr2:1575348 G/A cg01028140 chr2:1542097 TPO -0.57 -11.62 -0.42 1.89e-28 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6598955 0.627 rs6684875 chr1:26567044 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg00106254 chr7:1943704 MAD1L1 0.38 10.31 0.38 3.81e-23 Bipolar disorder and schizophrenia; BRCA cis rs1003719 0.680 rs2835668 chr21:38580151 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.51 -0.5 1.83e-41 Eye color traits; BRCA cis rs10751667 0.643 rs7394436 chr11:970373 G/C cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs2637266 1.000 rs2395410 chr10:78381767 C/T cg18941641 chr10:78392320 NA 0.35 7.84 0.3 1.85e-14 Pulmonary function; BRCA cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 10.75 0.39 7.11e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg06784218 chr1:46089804 CCDC17 0.51 12.25 0.44 3.85e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7618501 1.000 rs2234391 chr3:49842625 A/G cg21582582 chr3:182698605 DCUN1D1 0.36 9.52 0.35 3.53e-20 Intelligence (multi-trait analysis); BRCA cis rs250677 0.524 rs250665 chr5:148454394 A/C cg12140854 chr5:148520817 ABLIM3 -0.37 -8.41 -0.32 2.6e-16 Breast cancer; BRCA cis rs208520 0.690 rs3899423 chr6:66835285 A/G cg07460842 chr6:66804631 NA -0.97 -19.12 -0.6 8.49e-65 Exhaled nitric oxide output; BRCA cis rs9790314 0.663 rs7630674 chr3:160813597 G/A cg03342759 chr3:160939853 NMD3 -0.52 -10.73 -0.39 8.47e-25 Morning vs. evening chronotype; BRCA cis rs9467773 0.620 rs6925087 chr6:26592853 T/A cg09904177 chr6:26538194 HMGN4 0.47 15.0 0.51 8.32e-44 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg22535103 chr8:58192502 C8orf71 -0.49 -9.53 -0.35 3.18e-20 Developmental language disorder (linguistic errors); BRCA cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg12573674 chr2:1569213 NA -0.47 -9.26 -0.34 3.18e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3008870 1.000 rs3008870 chr1:67418027 C/T cg08660285 chr1:67390436 MIER1;WDR78 1.0 23.01 0.67 8.16e-86 Lymphocyte percentage of white cells; BRCA cis rs9527 0.615 rs4919685 chr10:104587362 G/T cg04362960 chr10:104952993 NT5C2 0.48 10.1 0.37 2.46e-22 Arsenic metabolism; BRCA cis rs73242632 1.000 rs3775083 chr4:57868186 A/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.69 8.27 0.31 8.02e-16 Congenital heart disease (maternal effect); BRCA cis rs6694270 0.913 rs11261069 chr1:19117300 C/G cg26220594 chr1:19110978 NA -0.43 -8.31 -0.31 5.65e-16 Drug-induced liver injury (nitrofurantoin); BRCA cis rs6120849 0.754 rs6120819 chr20:33653038 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.03 0.37 4.23e-22 Protein C levels; BRCA cis rs8062405 0.965 rs8049439 chr16:28837515 A/G cg16576597 chr16:28551801 NUPR1 0.27 7.88 0.3 1.42e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2439831 0.850 rs28684672 chr15:44107662 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.73 12.32 0.44 2e-31 Lung cancer in ever smokers; BRCA cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg11833968 chr6:79620685 NA -0.45 -9.83 -0.36 2.46e-21 Intelligence (multi-trait analysis); BRCA trans rs1005277 0.579 rs2474572 chr10:38385316 A/G cg17830980 chr10:43048298 ZNF37B -0.54 -13.02 -0.46 1.52e-34 Extrinsic epigenetic age acceleration; BRCA trans rs7824557 0.872 rs1347410 chr8:11111242 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -10.06 -0.37 3.2800000000000002e-22 Retinal vascular caliber; BRCA cis rs858239 0.601 rs764533 chr7:23153875 C/T cg23682824 chr7:23144976 KLHL7 0.42 10.79 0.39 4.58e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs7301826 1.000 rs4759787 chr12:131290180 A/C cg11011512 chr12:131303247 STX2 0.42 10.83 0.39 3.21e-25 Plasma plasminogen activator levels; BRCA cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg04315214 chr1:2043799 PRKCZ -0.48 -12.73 -0.45 3.12e-33 Height; BRCA cis rs6120849 0.754 rs6120813 chr20:33642112 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs3824867 0.920 rs80241400 chr11:47453828 T/C cg20307385 chr11:47447363 PSMC3 -0.51 -11.43 -0.41 1.22e-27 Mean corpuscular hemoglobin; BRCA cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg01528321 chr10:82214614 TSPAN14 0.62 13.83 0.48 3.07e-38 Post bronchodilator FEV1; BRCA cis rs849141 0.890 rs860263 chr7:28182346 A/G cg22892036 chr7:28189139 JAZF1 0.47 8.4 0.32 2.84e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs7552404 0.727 rs5745433 chr1:76333163 T/G cg22875332 chr1:76189707 ACADM 0.61 11.56 0.42 3.21e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs922182 0.617 rs13329183 chr15:64240809 A/G cg24729988 chr15:64271149 DAPK2 0.49 10.65 0.39 1.69e-24 Blood protein levels; BRCA cis rs6963495 0.769 rs117986187 chr7:105167311 G/A cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA trans rs1997103 1.000 rs6976824 chr7:55396115 A/C cg20935933 chr6:143382018 AIG1 0.58 10.91 0.4 1.57e-25 QRS interval (sulfonylurea treatment interaction); BRCA cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.76e-31 Blood protein levels; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg08132940 chr7:1081526 C7orf50 -0.54 -8.41 -0.32 2.68e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3772130 0.583 rs12695415 chr3:121398853 C/T cg20356878 chr3:121714668 ILDR1 0.38 8.6 0.32 6.17e-17 Cognitive performance; BRCA cis rs586533 0.881 rs638688 chr11:99504511 A/T cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg19346786 chr7:2764209 NA -0.31 -9.05 -0.34 1.67e-18 Height; BRCA cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.56 0.35 2.42e-20 Morning vs. evening chronotype; BRCA cis rs2066819 1.000 rs76466034 chr12:56719450 G/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs6748734 1.000 rs6748734 chr2:241837452 A/G cg07537917 chr2:241836409 C2orf54 -0.48 -11.19 -0.4 1.18e-26 Urinary metabolites; BRCA cis rs11249608 0.548 rs62393076 chr5:178450646 C/G cg21905437 chr5:178450457 ZNF879 0.55 11.44 0.41 1.07e-27 Pubertal anthropometrics; BRCA cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg18404041 chr3:52824283 ITIH1 0.38 11.77 0.42 4.43e-29 Electroencephalogram traits; BRCA cis rs6088580 0.524 rs6088564 chr20:33249444 A/G cg07148914 chr20:33460835 GGT7 -0.37 -7.97 -0.3 7.47e-15 Glomerular filtration rate (creatinine); BRCA cis rs11112613 0.762 rs73184078 chr12:105950017 A/G cg03607813 chr12:105948248 NA 0.6 11.21 0.41 9.41e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs10751667 0.714 rs7933889 chr11:972270 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs10504229 1.000 rs67105789 chr8:58192002 G/T cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.967 rs2040499 chr7:91809657 C/G cg17063962 chr7:91808500 NA -0.6 -13.95 -0.48 8.4e-39 Breast cancer; BRCA cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg27211696 chr2:191398769 TMEM194B -0.46 -10.72 -0.39 9.22e-25 Pulse pressure; BRCA cis rs9393777 0.513 rs13219181 chr6:27136225 A/G cg12292205 chr6:26970375 C6orf41 -0.65 -10.04 -0.37 3.89e-22 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg18402987 chr7:1209562 NA 0.43 8.18 0.31 1.55e-15 Longevity;Endometriosis; BRCA cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg04450456 chr4:17643702 FAM184B 0.37 9.89 0.36 1.5e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg03806693 chr22:41940476 POLR3H 1.1 19.5 0.61 8.78e-67 Vitiligo; BRCA cis rs208520 0.690 rs7764570 chr6:66827600 G/C cg07460842 chr6:66804631 NA -0.92 -18.3 -0.59 1.86e-60 Exhaled nitric oxide output; BRCA cis rs7613875 0.620 rs7634441 chr3:50071677 G/A cg05623727 chr3:50126028 RBM5 -0.49 -12.12 -0.43 1.44e-30 Body mass index; BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.26 0.34 3.15e-19 Tonsillectomy; BRCA cis rs2425143 1.000 rs17093027 chr20:34319118 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA trans rs877282 0.853 rs7079450 chr10:755932 T/A cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.36 -8.71 -0.33 2.6e-17 Personality dimensions; BRCA cis rs11098499 0.738 rs72918577 chr4:120326701 G/A cg09307838 chr4:120376055 NA 0.76 16.77 0.55 1.42e-52 Corneal astigmatism; BRCA cis rs1035144 0.505 rs10145099 chr14:81456694 C/T cg06600135 chr14:81408086 NA -0.46 -10.76 -0.39 6.18e-25 Male sexual orientation; BRCA cis rs8177179 0.967 rs9869311 chr3:133451613 C/T cg24879335 chr3:133465180 TF 0.33 11.08 0.4 3.25e-26 Iron status biomarkers (transferrin levels); BRCA trans rs11722228 0.539 rs62287552 chr4:10153197 C/T cg26043149 chr18:55253948 FECH 1.18 27.27 0.73 3.37e-109 Gout;Urate levels;Serum uric acid levels; BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.57 0.32 7.65e-17 Tonsillectomy; BRCA cis rs9467773 0.967 rs6456732 chr6:26514445 T/C cg11502198 chr6:26597334 ABT1 0.47 9.47 0.35 5.19e-20 Intelligence (multi-trait analysis); BRCA cis rs2016266 0.929 rs11170495 chr12:53665202 G/A cg26875137 chr12:53738046 NA 0.36 9.64 0.36 1.22e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.42 0.44 6.9e-32 Bipolar disorder; BRCA cis rs10504229 1.000 rs116995796 chr8:58181960 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs8177253 1.000 rs6762719 chr3:133480817 A/G cg12373951 chr3:133503437 NA 0.45 10.6 0.39 2.67e-24 Iron status biomarkers; BRCA cis rs11792861 0.926 rs1051474 chr9:111881856 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 7.97 0.3 7.15e-15 Menarche (age at onset); BRCA cis rs10499694 0.933 rs12718583 chr7:50582631 T/C cg18232548 chr7:50535776 DDC -0.39 -9.31 -0.35 2.06e-19 Body mass index; BRCA cis rs735860 0.712 rs2294864 chr6:53140928 T/A cg10236188 chr6:53219634 NA -0.39 -8.25 -0.31 9.29e-16 Glaucoma; BRCA cis rs4970988 0.527 rs12067556 chr1:150614535 G/A cg18016565 chr1:150552671 MCL1 0.37 8.51 0.32 1.21e-16 Urate levels; BRCA cis rs875971 1.000 rs778694 chr7:65871558 A/G cg11764359 chr7:65958608 NA 0.8 19.49 0.61 9.4e-67 Aortic root size; BRCA cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg04234412 chr22:24373322 LOC391322 -0.44 -8.88 -0.33 6.5e-18 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs801193 0.569 rs2659892 chr7:66200305 A/G cg18876405 chr7:65276391 NA 0.48 10.83 0.39 3.43e-25 Aortic root size; BRCA cis rs4713118 0.869 rs9348775 chr6:27695329 C/T cg26587870 chr6:27730563 NA -0.38 -8.36 -0.31 3.99e-16 Parkinson's disease; BRCA cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg01448562 chr3:133502909 NA -0.62 -14.59 -0.5 7.79e-42 Iron status biomarkers; BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.1 -0.43 1.65e-30 Gut microbiome composition (summer); BRCA cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg26022315 chr17:47021804 SNF8 0.3 7.93 0.3 9.5e-15 Type 2 diabetes; BRCA cis rs7267979 0.868 rs6138550 chr20:25223430 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.39 0.31 3.15e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7927592 0.913 rs3758643 chr11:68367193 C/T cg20283391 chr11:68216788 NA -0.46 -9.07 -0.34 1.48e-18 Total body bone mineral density; BRCA cis rs6542838 0.611 rs1878589 chr2:99517979 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.38 -8.55 -0.32 8.94e-17 Fear of minor pain; BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.01 -0.3 5.36e-15 Developmental language disorder (linguistic errors); BRCA cis rs490234 0.783 rs13283793 chr9:128441641 C/T cg14078157 chr9:128172775 NA -0.35 -8.24 -0.31 1e-15 Mean arterial pressure; BRCA trans rs11098499 0.648 rs2002047 chr4:120257228 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.62 0.39 2.31e-24 Corneal astigmatism; BRCA cis rs7945705 0.747 rs2742480 chr11:8993130 A/G cg12365402 chr11:9010492 NRIP3 -0.44 -10.32 -0.38 3.41e-23 Hemoglobin concentration; BRCA cis rs7100689 0.784 rs3120977 chr10:82075324 C/G cg01528321 chr10:82214614 TSPAN14 0.92 20.04 0.62 1.07e-69 Post bronchodilator FEV1; BRCA cis rs752010 0.523 rs10890158 chr1:42117985 C/T cg06885757 chr1:42089581 HIVEP3 0.28 9.75 0.36 4.91e-21 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg08470875 chr2:26401718 FAM59B 0.73 11.91 0.43 1.08e-29 Gut microbiome composition (summer); BRCA cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 8.25 0.31 9.33e-16 Schizophrenia; BRCA cis rs4237845 0.551 rs116263297 chr12:58273445 A/C cg00677455 chr12:58241039 CTDSP2 0.69 15.93 0.53 2.39e-48 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.818 rs557553 chr1:153010370 T/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.05e-17 Inflammatory skin disease; BRCA cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.86 -0.33 7.87e-18 Intelligence (multi-trait analysis); BRCA cis rs1865760 1.000 rs6910174 chr6:25904414 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.34 0.38 2.87e-23 Height; BRCA cis rs6840258 1.000 rs6840258 chr4:87973668 C/T cg08197287 chr4:87952173 AFF1 -0.45 -9.13 -0.34 9.08e-19 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs6831352 0.703 rs2602854 chr4:100028651 C/T cg12011299 chr4:100065546 ADH4 0.42 10.63 0.39 2.05e-24 Alcohol dependence; BRCA cis rs7267979 1.000 rs4815408 chr20:25346678 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.14 -0.34 8.37e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs727479 0.502 rs12148604 chr15:51501404 A/G cg19946085 chr15:51559439 CYP19A1 0.29 8.13 0.31 2.31e-15 Estradiol levels; BRCA cis rs4689388 0.853 rs13103357 chr4:6294544 A/G cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6088590 1.000 rs28542147 chr20:33376323 G/A cg06115741 chr20:33292138 TP53INP2 0.5 11.29 0.41 4.34e-27 Coronary artery disease; BRCA cis rs2991971 0.967 rs12743512 chr1:45954033 A/G cg15605315 chr1:45957053 TESK2 -0.5 -10.03 -0.37 4.24e-22 High light scatter reticulocyte count; BRCA cis rs832540 0.656 rs832573 chr5:56159578 T/C cg18230493 chr5:56204884 C5orf35 -0.39 -8.0 -0.3 5.96e-15 Coronary artery disease; BRCA cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.36 0.44 1.23e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs34779708 0.966 rs2045917 chr10:35418526 G/A cg03585969 chr10:35415529 CREM 0.49 10.31 0.38 3.76e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836974 0.897 rs12481860 chr21:40537836 T/A cg11644478 chr21:40555479 PSMG1 0.82 18.68 0.59 1.91e-62 Cognitive function; BRCA cis rs36051895 0.659 rs10283730 chr9:5073289 G/A cg02405213 chr9:5042618 JAK2 -0.53 -9.42 -0.35 8.04e-20 Pediatric autoimmune diseases; BRCA cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg00339695 chr16:24857497 SLC5A11 0.35 8.41 0.32 2.64e-16 Intelligence (multi-trait analysis); BRCA cis rs2171564 0.557 rs9831780 chr3:112442083 G/A cg06685282 chr3:112453648 NA 0.52 11.68 0.42 1.05e-28 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg26314531 chr2:26401878 FAM59B -0.88 -15.45 -0.52 5.59e-46 Gut microbiome composition (summer); BRCA cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.17 0.31 1.68e-15 Depression; BRCA cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.32 0.31 5.31e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2204008 0.715 rs12815986 chr12:38343869 G/A cg06521331 chr12:34319734 NA -0.52 -9.32 -0.35 1.89e-19 Bladder cancer; BRCA trans rs61931739 0.635 rs10743837 chr12:33982162 A/G cg26384229 chr12:38710491 ALG10B 0.4 8.95 0.33 3.69e-18 Morning vs. evening chronotype; BRCA cis rs2404602 0.611 rs2404734 chr15:76936165 T/C cg23625390 chr15:77176239 SCAPER -0.54 -12.8 -0.45 1.52e-33 Blood metabolite levels; BRCA cis rs9986765 1.000 rs73452567 chr7:142816043 T/G cg21852589 chr7:142981689 TMEM139 0.63 10.18 0.37 1.14e-22 Cancer;Dermatomyositis; BRCA cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg13319975 chr6:146136371 FBXO30 0.59 13.19 0.46 2.58e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs7255436 0.965 rs11668346 chr19:8450854 A/T cg10811474 chr19:8428787 ANGPTL4 -0.33 -8.35 -0.31 4.15e-16 HDL cholesterol; BRCA cis rs6831352 0.819 rs2851274 chr4:100025866 G/C cg12011299 chr4:100065546 ADH4 0.44 11.37 0.41 2.07e-27 Alcohol dependence; BRCA cis rs7659604 0.540 rs4833769 chr4:122672970 A/C cg19671926 chr4:122722719 EXOSC9 -0.42 -9.01 -0.34 2.35e-18 Type 2 diabetes; BRCA cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg16339924 chr4:17578868 LAP3 0.76 19.09 0.6 1.26e-64 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2153535 0.580 rs6912374 chr6:8456423 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs2836974 0.932 rs2836953 chr21:40617483 G/A cg17971929 chr21:40555470 PSMG1 0.81 19.45 0.61 1.49e-66 Cognitive function; BRCA cis rs1005224 0.654 rs8005753 chr14:76136086 A/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.22 -0.31 1.11e-15 Large artery stroke; BRCA cis rs11608355 0.545 rs35590455 chr12:109893514 A/G cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA trans rs4650994 0.525 rs4993304 chr1:178535144 A/G cg05059571 chr16:84539110 KIAA1609 -0.58 -12.8 -0.45 1.47e-33 HDL cholesterol levels;HDL cholesterol; BRCA cis rs13217239 0.646 rs10456351 chr6:26986792 C/T cg12292205 chr6:26970375 C6orf41 0.58 13.04 0.46 1.2e-34 Schizophrenia; BRCA cis rs2841277 0.646 rs3742935 chr14:105405599 G/C cg14403583 chr14:105418241 AHNAK2 -0.38 -8.97 -0.33 3.29e-18 Rheumatoid arthritis; BRCA cis rs7582180 0.764 rs11686293 chr2:100922830 C/T cg14675211 chr2:100938903 LONRF2 0.48 11.09 0.4 2.83e-26 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.38 -0.41 1.84e-27 Gut microbiome composition (summer); BRCA cis rs7586879 0.789 rs13382979 chr2:25131736 G/A cg04586622 chr2:25135609 ADCY3 0.4 9.46 0.35 5.57e-20 Body mass index; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg03923535 chr7:1197113 ZFAND2A 0.46 10.3 0.38 3.9e-23 Longevity;Endometriosis; BRCA cis rs4727027 0.866 rs1358062 chr7:148783743 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 10.71 0.39 9.47e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg15704280 chr7:45808275 SEPT13 -0.84 -19.11 -0.6 9.63e-65 Height; BRCA cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg09877947 chr5:131593287 PDLIM4 0.39 9.79 0.36 3.46e-21 Breast cancer; BRCA cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg12386194 chr3:101231763 SENP7 0.46 9.86 0.36 1.99e-21 Colorectal cancer; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg14863265 chr7:2801509 GNA12 -0.44 -9.52 -0.35 3.41e-20 Height; BRCA cis rs2072499 0.966 rs2842869 chr1:156160696 A/G cg25208724 chr1:156163844 SLC25A44 1.07 35.23 0.81 7.01e-152 Testicular germ cell tumor; BRCA cis rs10028773 0.666 rs12498657 chr4:120262866 G/C cg09307838 chr4:120376055 NA 0.6 12.96 0.46 2.83e-34 Educational attainment; BRCA cis rs7044106 0.762 rs1324473 chr9:123404610 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 -0.63 -13.23 -0.46 1.75e-35 Hip circumference adjusted for BMI; BRCA cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.27 -0.38 5.26e-23 Heart rate; BRCA cis rs2777491 0.574 rs28700583 chr15:41714072 C/T cg18705301 chr15:41695430 NDUFAF1 -1.08 -27.37 -0.73 9.73e-110 Ulcerative colitis; BRCA cis rs7918232 0.941 rs788220 chr10:27447205 T/C cg14442939 chr10:27389572 ANKRD26 -0.68 -10.91 -0.4 1.61e-25 Breast cancer; BRCA cis rs3784262 0.709 rs4080 chr15:58201341 C/G cg12031962 chr15:58353849 ALDH1A2 0.34 9.22 0.34 4.38e-19 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg24110177 chr3:50126178 RBM5 -0.44 -9.79 -0.36 3.61e-21 Intelligence (multi-trait analysis); BRCA cis rs2505998 1.000 rs2435362 chr10:43578779 A/C cg15436174 chr10:43711423 RASGEF1A -0.42 -8.38 -0.31 3.45e-16 Hirschsprung disease; BRCA cis rs9811920 0.529 rs793442 chr3:99581062 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.68 -15.8 -0.53 1.05e-47 Axial length; BRCA cis rs1707322 1.000 rs3922886 chr1:46473902 A/T cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.19e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs738322 0.600 rs6001035 chr22:38562425 A/G cg20207973 chr22:38506712 BAIAP2L2 0.32 7.9 0.3 1.19e-14 Cutaneous nevi; BRCA trans rs1005277 0.579 rs2800485 chr10:38542588 G/A cg17830980 chr10:43048298 ZNF37B -0.53 -12.72 -0.45 3.4e-33 Extrinsic epigenetic age acceleration; BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg14863265 chr7:2801509 GNA12 -0.46 -9.65 -0.36 1.14e-20 Height; BRCA cis rs897984 0.568 rs8063565 chr16:30883965 G/C cg02466173 chr16:30829666 NA 0.46 9.11 0.34 1.01e-18 Dementia with Lewy bodies; BRCA cis rs10883723 0.810 rs13287 chr10:104240438 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.23 0.61 2.31e-65 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6604026 0.666 rs11164830 chr1:93356823 C/A cg17283838 chr1:93427260 FAM69A -0.4 -8.22 -0.31 1.14e-15 Multiple sclerosis; BRCA cis rs7635838 0.684 rs346079 chr3:11328139 G/A cg00170343 chr3:11313890 ATG7 0.41 8.52 0.32 1.14e-16 HDL cholesterol; BRCA cis rs2559856 1.000 rs2695288 chr12:102088112 T/C cg12924262 chr12:102091054 CHPT1 0.38 8.67 0.32 3.54e-17 Blood protein levels; BRCA cis rs2576037 0.583 rs501882 chr18:44411066 A/T cg15049968 chr18:44337910 ST8SIA5 -0.27 -7.81 -0.3 2.35e-14 Personality dimensions; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg21747090 chr2:27597821 SNX17 -0.4 -8.8 -0.33 1.24e-17 Total body bone mineral density; BRCA cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg24838063 chr12:130822603 PIWIL1 0.68 16.73 0.55 2.13e-52 Menopause (age at onset); BRCA cis rs9649213 0.593 rs1468340 chr7:97987676 T/G cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.43e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05901451 chr6:126070800 HEY2 -0.39 -9.49 -0.35 4.46e-20 Endometrial cancer; BRCA cis rs9486719 1.000 rs12208124 chr6:97027942 C/T cg06623918 chr6:96969491 KIAA0776 -0.75 -13.3 -0.47 8.71e-36 Migraine;Coronary artery disease; BRCA cis rs4268898 0.662 rs9784114 chr2:24437517 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.23 0.31 1.05e-15 Asthma; BRCA cis rs9633740 1.000 rs10748526 chr10:82273079 T/C cg00277334 chr10:82204260 NA -0.42 -7.86 -0.3 1.69e-14 Post bronchodilator FEV1; BRCA cis rs7246657 0.722 rs2972447 chr19:38129736 C/T cg18154014 chr19:37997991 ZNF793 -0.49 -9.24 -0.34 3.72e-19 Coronary artery calcification; BRCA cis rs9814567 1.000 rs9828815 chr3:134265749 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.2 0.49 5.86e-40 Motion sickness; BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 18.83 0.6 3.04e-63 Platelet count; BRCA cis rs60871478 0.947 rs62432862 chr7:807719 G/C cg04727924 chr7:799746 HEATR2 -0.55 -10.89 -0.4 1.96e-25 Cerebrospinal P-tau181p levels; BRCA cis rs367943 0.556 rs7709820 chr5:112991327 G/A cg12552261 chr5:112820674 MCC 0.37 8.13 0.31 2.3e-15 Type 2 diabetes; BRCA cis rs365132 1.000 rs353478 chr5:176370988 T/C cg16309518 chr5:176445507 NA -0.53 -13.62 -0.47 2.88e-37 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.85 -0.3 1.75e-14 Total body bone mineral density; BRCA cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg24812749 chr6:127587940 RNF146 0.7 15.39 0.52 1.13e-45 Breast cancer; BRCA cis rs9858542 0.953 rs9841110 chr3:49492481 C/G cg07274523 chr3:49395745 GPX1 0.46 7.84 0.3 1.84e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9811920 0.683 rs16841874 chr3:99720564 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -11.04 -0.4 4.66e-26 Axial length; BRCA cis rs4285028 0.948 rs2332033 chr3:121699548 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.57 -10.55 -0.39 4.29e-24 Multiple sclerosis; BRCA cis rs4595586 0.545 rs12828001 chr12:39392208 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs13191362 0.935 rs35378894 chr6:163123933 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.4 0.38 1.71e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs35110281 0.626 rs162368 chr21:44934767 G/A cg21573476 chr21:45109991 RRP1B -0.33 -8.45 -0.32 1.98e-16 Mean corpuscular volume; BRCA cis rs1005277 0.505 rs200936 chr10:38134935 T/C cg25427524 chr10:38739819 LOC399744 -0.66 -16.16 -0.54 1.65e-49 Extrinsic epigenetic age acceleration; BRCA cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg22920501 chr2:26401640 FAM59B -0.66 -11.46 -0.41 8.67e-28 Gut microbiome composition (summer); BRCA cis rs4662945 0.603 rs13002385 chr2:130276865 T/C cg05962382 chr2:130345044 NA -0.36 -8.51 -0.32 1.23e-16 Response to cytidine analogues (gemcitabine); BRCA trans rs1997103 1.000 rs6958022 chr7:55397389 G/A cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2481665 0.772 rs12730782 chr1:62537265 A/G cg18591186 chr1:62594603 INADL -0.56 -12.24 -0.44 4.27e-31 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs28735056 0.591 rs2277724 chr18:77694294 C/A cg20368463 chr18:77673604 PQLC1 -0.51 -12.76 -0.45 2.15e-33 Schizophrenia; BRCA cis rs17270561 0.609 rs1165181 chr6:25825390 T/A cg17691542 chr6:26056736 HIST1H1C 0.44 9.44 0.35 6.79e-20 Iron status biomarkers; BRCA cis rs858239 0.508 rs2390754 chr7:23190494 A/G cg23682824 chr7:23144976 KLHL7 0.37 9.8 0.36 3.27e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs4074536 0.622 rs6668528 chr1:116314321 G/A cg21648376 chr1:116311395 CASQ2 -0.55 -9.02 -0.34 2.21e-18 QRS duration; BRCA cis rs12760731 0.565 rs7536856 chr1:178057927 A/G cg00404053 chr1:178313656 RASAL2 0.64 8.06 0.3 3.66e-15 Obesity-related traits; BRCA cis rs67366981 1.000 rs17105547 chr14:77698358 G/A cg22824376 chr14:77648248 TMEM63C 0.62 9.1 0.34 1.15e-18 Obsessive-compulsive symptoms; BRCA cis rs6815814 0.950 rs73236618 chr4:38794041 T/C cg02016764 chr4:38805732 TLR1 -0.6 -9.11 -0.34 1.06e-18 Breast cancer; BRCA trans rs7824557 0.767 rs3808509 chr8:11163256 G/T cg06636001 chr8:8085503 FLJ10661 0.54 10.16 0.37 1.42e-22 Retinal vascular caliber; BRCA cis rs8014204 0.762 rs973879 chr14:75297727 T/C cg06637938 chr14:75390232 RPS6KL1 0.42 8.81 0.33 1.15e-17 Caffeine consumption; BRCA cis rs8177253 0.665 rs12493887 chr3:133440737 T/C cg01448562 chr3:133502909 NA -0.39 -9.01 -0.34 2.38e-18 Iron status biomarkers; BRCA cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg23719950 chr11:63933701 MACROD1 -0.58 -9.62 -0.36 1.45e-20 Mean platelet volume; BRCA cis rs2762353 0.779 rs1165182 chr6:25837829 A/G cg12310025 chr6:25882481 NA -0.54 -13.09 -0.46 7.43e-35 Blood metabolite levels; BRCA trans rs9329221 0.741 rs534523 chr8:9884999 C/G cg06636001 chr8:8085503 FLJ10661 -0.47 -9.92 -0.37 1.1e-21 Neuroticism; BRCA cis rs473651 0.901 rs563282 chr2:239329736 T/C cg21699342 chr2:239360505 ASB1 0.47 11.85 0.42 1.95e-29 Multiple system atrophy; BRCA cis rs11690935 0.595 rs788170 chr2:172919958 T/C cg13550731 chr2:172543902 DYNC1I2 0.56 14.18 0.49 7.11e-40 Schizophrenia; BRCA cis rs4466137 0.951 rs336958 chr5:82973396 A/G cg15083037 chr5:83017644 HAPLN1 -0.43 -8.05 -0.3 4.08e-15 Prostate cancer; BRCA cis rs7903847 0.620 rs10882903 chr10:99115584 A/T cg20016023 chr10:99160130 RRP12 -0.25 -7.85 -0.3 1.79e-14 Granulocyte percentage of myeloid white cells; BRCA cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg11764359 chr7:65958608 NA -0.8 -19.59 -0.61 2.9e-67 Aortic root size; BRCA cis rs2964802 0.505 rs7737359 chr5:10832104 A/G cg14521931 chr5:10832172 NA -0.47 -10.17 -0.37 1.24e-22 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs12477438 0.520 rs7572660 chr2:99788582 A/G cg08885076 chr2:99613938 TSGA10 0.44 10.21 0.37 9.27e-23 Chronic sinus infection; BRCA cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg26587870 chr6:27730563 NA -0.39 -8.3 -0.31 6.14e-16 Parkinson's disease; BRCA cis rs13191362 0.938 rs35395472 chr6:163008493 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7903847 0.642 rs9887991 chr10:99159634 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.88 -0.33 6.73e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs17401966 0.964 rs17400510 chr1:10290421 T/C cg03954927 chr1:10346856 KIF1B 0.44 12.99 0.46 2.1e-34 Hepatocellular carcinoma; BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 18.46 0.59 2.64e-61 Alzheimer's disease; BRCA cis rs6831352 0.918 rs17218108 chr4:100055755 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs10206020 0.885 rs11886082 chr2:1576683 T/C cg26248373 chr2:1572462 NA -0.59 -12.84 -0.45 9.74e-34 IgG glycosylation; BRCA cis rs796364 1.000 rs11694369 chr2:200741720 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -11.2 -0.41 1.05e-26 Schizophrenia; BRCA cis rs1215050 0.791 rs1648546 chr4:98899294 T/C cg05340658 chr4:99064831 C4orf37 -0.44 -9.94 -0.37 9.52e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4900538 0.927 rs8005804 chr14:102957803 A/G cg18135206 chr14:102964638 TECPR2 1.05 29.71 0.76 1.64e-122 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg02297831 chr4:17616191 MED28 0.35 7.93 0.3 9.66e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7819412 0.522 rs3021495 chr8:10994743 C/G cg21775007 chr8:11205619 TDH -0.45 -8.48 -0.32 1.6e-16 Triglycerides; BRCA cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs11722228 0.549 rs56146302 chr4:10081052 C/T cg26043149 chr18:55253948 FECH 1.1 23.27 0.68 3.3e-87 Gout;Urate levels;Serum uric acid levels; BRCA cis rs208520 0.837 rs208488 chr6:66926902 C/T cg07460842 chr6:66804631 NA -0.9 -15.72 -0.53 2.51e-47 Exhaled nitric oxide output; BRCA cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.27 0.31 7.99e-16 Mean platelet volume; BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg24642844 chr7:1081250 C7orf50 -0.69 -13.08 -0.46 8.25e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg00106254 chr7:1943704 MAD1L1 -0.45 -11.94 -0.43 7.97e-30 Bipolar disorder and schizophrenia; BRCA trans rs61931739 0.534 rs10844791 chr12:34211659 C/T cg26384229 chr12:38710491 ALG10B 0.67 14.35 0.49 1.15e-40 Morning vs. evening chronotype; BRCA cis rs1707322 0.717 rs3014249 chr1:46079493 A/G cg03146154 chr1:46216737 IPP -0.5 -11.0 -0.4 6.76e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1005277 0.579 rs2505198 chr10:38393183 A/C cg23533926 chr12:111358616 MYL2 -0.41 -8.71 -0.33 2.67e-17 Extrinsic epigenetic age acceleration; BRCA trans rs61931739 0.782 rs1197569 chr12:34186733 A/T cg26384229 chr12:38710491 ALG10B 0.43 10.31 0.38 3.53e-23 Morning vs. evening chronotype; BRCA cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg23018236 chr17:30244563 NA -0.69 -10.69 -0.39 1.19e-24 Hip circumference adjusted for BMI; BRCA cis rs546131 0.928 rs558967 chr11:34827168 T/A cg11058730 chr11:34937778 PDHX;APIP 0.42 7.99 0.3 6.15e-15 Lung disease severity in cystic fibrosis; BRCA cis rs4478858 0.684 rs10798838 chr1:31719450 G/A cg00250761 chr1:31883323 NA -0.31 -8.0 -0.3 6.03e-15 Alcohol dependence; BRCA cis rs3008870 1.000 rs1925411 chr1:67370292 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.96 21.04 0.64 4.62e-75 Lymphocyte percentage of white cells; BRCA cis rs7572263 0.652 rs34575089 chr2:209047368 G/A cg23998903 chr2:209048830 C2orf80 -0.38 -8.33 -0.31 5.03e-16 Glioma;Non-glioblastoma glioma; BRCA cis rs1153858 1.000 rs1890565 chr15:45663299 T/C cg21132104 chr15:45694354 SPATA5L1 0.75 17.27 0.56 4.02e-55 Homoarginine levels; BRCA cis rs72781680 0.898 rs72796158 chr2:23935727 T/C cg08917208 chr2:24149416 ATAD2B 1.05 14.38 0.49 7.78e-41 Lymphocyte counts; BRCA cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg26587870 chr6:27730563 NA -0.42 -9.05 -0.34 1.75e-18 Parkinson's disease; BRCA cis rs4253311 0.544 rs4253236 chr4:187148071 T/C cg24794857 chr4:187113578 CYP4V2 0.39 8.05 0.3 4.15e-15 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; BRCA cis rs9473147 0.516 rs2171089 chr6:47515811 A/G cg12968598 chr6:47444699 CD2AP 0.47 9.95 0.37 9.13e-22 Platelet distribution width;Mean platelet volume; BRCA cis rs926392 0.640 rs1007913 chr20:37693592 G/A cg16355469 chr20:37678765 NA 0.48 11.24 0.41 7.27e-27 Dialysis-related mortality; BRCA cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg01475377 chr6:109611718 NA -0.6 -16.73 -0.55 2.36e-52 Reticulocyte fraction of red cells; BRCA cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg23711669 chr6:146136114 FBXO30 0.8 19.43 0.61 2.07e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.875 rs2777476 chr6:146345024 A/G cg23711669 chr6:146136114 FBXO30 0.72 16.53 0.55 2.42e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg03517284 chr6:25882590 NA -0.38 -8.31 -0.31 5.91e-16 Intelligence (multi-trait analysis); BRCA trans rs7746199 0.611 rs17750747 chr6:27730334 T/C cg06606381 chr12:133084897 FBRSL1 -0.89 -8.85 -0.33 8.51e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs495337 0.760 rs2769977 chr20:48527464 T/C cg17835207 chr20:48524531 SPATA2 -0.68 -16.81 -0.55 9.28e-53 Psoriasis; BRCA cis rs7647973 0.807 rs4955416 chr3:49108428 T/C cg07636037 chr3:49044803 WDR6 0.88 21.18 0.64 7.59e-76 Menarche (age at onset); BRCA cis rs1468333 0.824 rs10952 chr5:137588340 T/A cg27119451 chr5:137514611 BRD8;KIF20A 0.41 7.88 0.3 1.43e-14 Resting heart rate; BRCA trans rs7819412 0.668 rs2409714 chr8:11010118 A/G cg06636001 chr8:8085503 FLJ10661 -0.43 -8.92 -0.33 4.97e-18 Triglycerides; BRCA cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg02466173 chr16:30829666 NA -0.42 -9.47 -0.35 5.39e-20 Dementia with Lewy bodies; BRCA cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg24110177 chr3:50126178 RBM5 -0.51 -14.44 -0.5 3.99e-41 Intelligence (multi-trait analysis); BRCA cis rs2404602 0.647 rs12898416 chr15:77042292 C/G cg23625390 chr15:77176239 SCAPER -0.55 -12.83 -0.45 1.1e-33 Blood metabolite levels; BRCA cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg17971929 chr21:40555470 PSMG1 0.79 18.57 0.59 6.58e-62 Cognitive function; BRCA cis rs7520050 0.966 rs4660910 chr1:46548402 G/T cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.42e-19 Red blood cell count;Reticulocyte count; BRCA cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg10802521 chr3:52805072 NEK4 -0.32 -8.17 -0.31 1.59e-15 Bipolar disorder; BRCA cis rs2762353 0.845 rs1937130 chr6:25787554 T/A cg03517284 chr6:25882590 NA 0.47 10.45 0.38 1.04e-23 Blood metabolite levels; BRCA cis rs4927850 0.752 rs7624460 chr3:195748530 C/T cg12923728 chr3:195709715 SDHAP1 -0.6 -13.08 -0.46 8.62e-35 Pancreatic cancer; BRCA cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg01579765 chr21:45077557 HSF2BP -0.41 -11.25 -0.41 6.33e-27 Mean corpuscular volume; BRCA cis rs11051970 0.659 rs904917 chr12:32591302 G/A cg02745156 chr12:32552066 NA 0.27 8.08 0.3 3.34e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg09184832 chr6:79620586 NA -0.49 -10.98 -0.4 8.39e-26 Intelligence (multi-trait analysis); BRCA cis rs2354432 0.607 rs894469 chr1:146672906 C/T cg25205988 chr1:146714368 CHD1L 0.84 10.87 0.4 2.19e-25 Mitochondrial DNA levels; BRCA trans rs1814175 0.817 rs10769598 chr11:49669326 C/G cg11707556 chr5:10655725 ANKRD33B -0.48 -11.87 -0.43 1.65e-29 Height; BRCA cis rs12472274 0.529 rs11677996 chr2:239118007 A/G cg17459225 chr2:239074497 NA 0.59 10.41 0.38 1.47e-23 Phospholipid levels (plasma); BRCA cis rs826838 0.934 rs10875647 chr12:38856995 G/A cg26384229 chr12:38710491 ALG10B 0.85 22.52 0.67 3.94e-83 Heart rate; BRCA cis rs829880 0.570 rs4488248 chr12:98853688 G/C cg25150519 chr12:98850993 NA 0.65 14.91 0.51 2.27e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs9457247 0.740 rs13195812 chr6:167443902 C/T cg07741184 chr6:167504864 NA 0.28 8.16 0.31 1.82e-15 Crohn's disease; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19717773 chr7:2847554 GNA12 -0.41 -7.85 -0.3 1.71e-14 Height; BRCA cis rs941873 0.868 rs2145998 chr10:81121696 T/A cg09469691 chr10:81107165 PPIF 0.45 9.77 0.36 4.01e-21 Height; BRCA trans rs1994135 0.617 rs10844644 chr12:33735871 A/G cg26384229 chr12:38710491 ALG10B 0.49 10.53 0.38 5.07e-24 Resting heart rate; BRCA cis rs3824867 0.881 rs4752829 chr11:47396654 G/A cg20307385 chr11:47447363 PSMC3 -0.49 -10.76 -0.39 6.46e-25 Mean corpuscular hemoglobin; BRCA cis rs4713118 0.824 rs13211701 chr6:27750079 T/C cg20933634 chr6:27740509 NA 0.49 9.82 0.36 2.62e-21 Parkinson's disease; BRCA cis rs6433895 1.000 rs35543145 chr2:182018115 A/G cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.54 0.57 1.68e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.36e-17 Developmental language disorder (linguistic errors); BRCA cis rs2243480 1.000 rs35820085 chr7:65442758 C/T cg18252515 chr7:66147081 NA -0.9 -12.91 -0.45 4.98e-34 Diabetic kidney disease; BRCA trans rs11098499 0.863 rs3775845 chr4:120432447 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.27 0.31 7.93e-16 Corneal astigmatism; BRCA cis rs701145 0.585 rs1960241 chr3:153858398 T/C cg12800244 chr3:153838788 SGEF 0.62 7.83 0.3 2.1e-14 Coronary artery disease; BRCA cis rs3784262 0.669 rs1063666 chr15:58246602 A/C cg12031962 chr15:58353849 ALDH1A2 -0.35 -9.61 -0.36 1.62e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9462846 1.000 rs9471941 chr6:42857827 C/T cg02353165 chr6:42928485 GNMT -0.47 -7.86 -0.3 1.63e-14 Blood protein levels; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg26516362 chr5:178986906 RUFY1 -0.45 -13.45 -0.47 1.73e-36 Lung cancer; BRCA cis rs6460942 0.915 rs7803051 chr7:12306904 A/T cg10578991 chr7:12443926 VWDE -0.44 -8.08 -0.3 3.35e-15 Coronary artery disease; BRCA cis rs7258465 0.965 rs10409003 chr19:18543054 C/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.76 -0.33 1.71e-17 Breast cancer; BRCA cis rs634534 0.561 rs655744 chr11:65776585 G/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.41 -9.98 -0.37 6.5600000000000005e-22 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs35146811 0.844 rs10281368 chr7:99655897 A/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.35 7.93 0.3 9.51e-15 Coronary artery disease; BRCA cis rs12142240 0.659 rs72677602 chr1:46837487 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.33 0.35 1.77e-19 Menopause (age at onset); BRCA cis rs1577917 0.687 rs1470531 chr6:86507369 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.11 -0.43 1.52e-30 Response to antipsychotic treatment; BRCA cis rs6121246 0.559 rs6060933 chr20:30351903 C/T cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.76 16.82 0.55 7.78e-53 Lymphocyte counts; BRCA cis rs1008375 1.000 rs7436403 chr4:17692685 T/G cg16339924 chr4:17578868 LAP3 -0.56 -13.56 -0.47 5.61e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs2797160 1.000 rs1739352 chr6:126005310 T/C cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.01e-14 Endometrial cancer; BRCA cis rs77956314 0.818 rs12296869 chr12:117431203 G/A cg02017074 chr12:117425053 FBXW8 -0.57 -8.95 -0.33 3.93e-18 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs754466 0.724 rs11002318 chr10:79633807 G/A cg17075019 chr10:79541650 NA -0.75 -18.04 -0.58 4.08e-59 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg24549020 chr5:56110836 MAP3K1 -0.4 -8.41 -0.32 2.78e-16 Initial pursuit acceleration; BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26314531 chr2:26401878 FAM59B -0.9 -15.7 -0.53 3.05e-47 Gut microbiome composition (summer); BRCA cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg01877450 chr7:97915802 BRI3 -0.37 -8.5 -0.32 1.31e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs17401966 1.000 rs2229687 chr1:10473196 C/T cg03954927 chr1:10346856 KIF1B 0.47 14.07 0.49 2.34e-39 Hepatocellular carcinoma; BRCA cis rs10504229 0.953 rs66815941 chr8:58187306 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs40363 0.723 rs2379831 chr16:3538927 T/C cg22508957 chr16:3507546 NAT15 -0.57 -8.33 -0.31 4.75e-16 Tuberculosis; BRCA cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg01483505 chr11:975446 AP2A2 -0.3 -8.05 -0.3 4.11e-15 Alzheimer's disease (late onset); BRCA cis rs9435341 0.896 rs1730851 chr1:107596443 A/G cg09367891 chr1:107599246 PRMT6 -0.43 -8.24 -0.31 9.74e-16 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs6089584 0.888 rs2892060 chr20:60617955 G/T cg06108461 chr20:60628389 TAF4 -0.99 -22.33 -0.66 4.6e-82 Body mass index; BRCA cis rs2153535 0.580 rs5001324 chr6:8451604 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs7072216 0.763 rs7923729 chr10:100169465 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs8058578 1.000 rs8058578 chr16:30726248 C/T cg00531865 chr16:30841666 NA -0.52 -12.2 -0.43 6.47e-31 Multiple myeloma; BRCA trans rs3733585 0.673 rs4292333 chr4:9953871 G/A cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 8.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg08807101 chr21:30365312 RNF160 0.74 19.41 0.61 2.47e-66 Dental caries; BRCA trans rs2204008 0.683 rs11522927 chr12:38137537 C/T cg06521331 chr12:34319734 NA -0.53 -9.49 -0.35 4.61e-20 Bladder cancer; BRCA cis rs9970334 0.596 rs709209 chr1:6278414 A/G cg15892785 chr1:6309343 GPR153 -0.42 -9.34 -0.35 1.63e-19 Resting heart rate; BRCA cis rs10949834 0.652 rs2269082 chr7:73519875 A/G cg07137043 chr7:73588983 EIF4H -0.53 -8.64 -0.32 4.61e-17 Verbal memory performance (residualized delayed recall change); BRCA cis rs751728 0.626 rs57150921 chr6:33737518 T/C cg25922239 chr6:33757077 LEMD2 0.52 13.2 0.46 2.44e-35 Crohn's disease; BRCA cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.43 0.35 7.24e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg18252515 chr7:66147081 NA -0.35 -7.83 -0.3 2.04e-14 Aortic root size; BRCA cis rs9649213 0.614 rs10953254 chr7:97914305 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.6 -14.83 -0.51 5.62e-43 Prostate cancer (SNP x SNP interaction); BRCA trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21659725 chr3:3221576 CRBN 0.71 22.09 0.66 8.94e-81 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs778705 chr7:65861115 G/A cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs3768617 0.811 rs12563494 chr1:183039698 G/A ch.1.3577855R chr1:183094577 LAMC1 0.46 9.94 0.37 9.49e-22 Fuchs's corneal dystrophy; BRCA cis rs7191700 0.673 rs12325495 chr16:11418328 C/T cg00044050 chr16:11439710 C16orf75 0.47 11.34 0.41 2.84e-27 Multiple sclerosis; BRCA trans rs1005277 0.579 rs2472175 chr10:38382901 T/G cg17830980 chr10:43048298 ZNF37B -0.57 -13.86 -0.48 2.11e-38 Extrinsic epigenetic age acceleration; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg04025307 chr7:1156635 C7orf50 0.46 9.19 0.34 5.33e-19 Bronchopulmonary dysplasia; BRCA cis rs7267979 1.000 rs4815417 chr20:25379526 C/T cg08601574 chr20:25228251 PYGB -0.36 -8.59 -0.32 6.58e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg08470875 chr2:26401718 FAM59B -0.54 -8.48 -0.32 1.58e-16 Gut microbiome composition (summer); BRCA cis rs6700896 0.931 rs12035753 chr1:66116691 T/G cg04111102 chr1:66153794 NA 0.34 8.42 0.32 2.57e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.22 -0.44 5.2e-31 Gut microbiome composition (summer); BRCA cis rs921968 0.541 rs7574429 chr2:219498759 T/G cg10223061 chr2:219282414 VIL1 -0.28 -7.99 -0.3 6.23e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs2131877 0.554 rs2131876 chr3:194854788 C/T cg13868855 chr3:194833887 C3orf21 -0.35 -8.35 -0.31 4.37e-16 Non-small cell lung cancer; BRCA cis rs6951245 1.000 rs74652290 chr7:1090109 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.84 -14.8 -0.51 7.83e-43 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8005677 0.962 rs34917191 chr14:23387628 T/C cg01529538 chr14:23388837 RBM23 0.42 11.48 0.41 7.01e-28 Cognitive ability (multi-trait analysis); BRCA cis rs2766692 1.000 rs4905941 chr14:100725438 A/G cg14866419 chr14:100704911 YY1 0.44 9.44 0.35 6.57e-20 Electroencephalographic traits in alcoholism; BRCA trans rs10028773 0.700 rs7671797 chr4:120248157 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.49 0.38 7.18e-24 Educational attainment; BRCA cis rs2637266 0.935 rs7909808 chr10:78392318 A/G cg18941641 chr10:78392320 NA 0.35 8.17 0.31 1.65e-15 Pulmonary function; BRCA cis rs7937682 0.602 rs11214036 chr11:111773169 C/T cg09085632 chr11:111637200 PPP2R1B -0.75 -17.23 -0.56 6.35e-55 Primary sclerosing cholangitis; BRCA cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg06671706 chr8:8559999 CLDN23 0.44 8.43 0.32 2.36e-16 Obesity-related traits; BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg14196790 chr5:131705035 SLC22A5 0.33 8.69 0.33 3.08e-17 Breast cancer; BRCA cis rs11605924 0.901 rs11607883 chr11:45839709 G/A ch.11.939596F chr11:45881766 CRY2 -0.45 -9.83 -0.36 2.47e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4927850 1.000 rs7627868 chr3:195753473 A/T cg12923728 chr3:195709715 SDHAP1 -0.58 -12.41 -0.44 7.61e-32 Pancreatic cancer; BRCA trans rs79976124 0.879 rs12214239 chr6:66636059 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.61 10.88 0.4 2.09e-25 Type 2 diabetes; BRCA cis rs2070488 1.000 rs1002675 chr3:38445226 C/T cg24069376 chr3:38537580 EXOG 0.38 10.89 0.4 1.84e-25 Electrocardiographic conduction measures; BRCA cis rs1975991 0.686 rs9824010 chr3:187961924 T/G cg15417654 chr3:187959138 LPP 0.35 9.07 0.34 1.47e-18 White matter integrity (bipolar disorder risk interaction); BRCA cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg03264133 chr6:25882463 NA -0.51 -10.67 -0.39 1.42e-24 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs870825 0.655 rs28604350 chr4:185638723 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.04e-56 Blood protein levels; BRCA cis rs9325144 0.723 rs11169519 chr12:39177441 G/A cg26384229 chr12:38710491 ALG10B -0.51 -11.42 -0.41 1.28e-27 Morning vs. evening chronotype; BRCA cis rs7551345 0.805 rs10914332 chr1:31699002 A/G cg19084893 chr1:31688959 NA -0.44 -8.61 -0.32 5.72e-17 Schizophrenia; BRCA cis rs243505 1.000 rs243512 chr7:148430062 C/T cg09806900 chr7:148480153 CUL1 -0.4 -8.27 -0.31 8.07e-16 Inflammatory bowel disease;Crohn's disease; BRCA trans rs61931739 0.500 rs11053251 chr12:34520743 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.12 0.34 9.85e-19 Morning vs. evening chronotype; BRCA cis rs826838 0.967 rs1352123 chr12:39130992 T/C cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg11657440 chr19:46296263 DMWD -0.44 -9.62 -0.36 1.49e-20 Coronary artery disease; BRCA cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg00990874 chr7:1149470 C7orf50 -0.6 -10.65 -0.39 1.72e-24 Bronchopulmonary dysplasia; BRCA cis rs10791323 0.572 rs4353292 chr11:133742656 A/G cg15485101 chr11:133734466 NA 0.38 10.19 0.37 1.08e-22 Childhood ear infection; BRCA cis rs3806843 0.868 rs2563291 chr5:140119599 T/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.6 0.35 1.81e-20 Depressive symptoms (multi-trait analysis); BRCA trans rs11098499 0.691 rs12510133 chr4:120271344 A/C cg25214090 chr10:38739885 LOC399744 0.45 10.66 0.39 1.59e-24 Corneal astigmatism; BRCA cis rs35110281 0.807 rs2838326 chr21:45014315 C/T cg01579765 chr21:45077557 HSF2BP -0.35 -9.58 -0.35 2.04e-20 Mean corpuscular volume; BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg16606324 chr3:10149918 C3orf24 0.49 9.76 0.36 4.36e-21 Alzheimer's disease; BRCA cis rs7917772 0.582 rs10786695 chr10:104368756 A/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.37 0.49 8.67e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6752107 1.000 rs3792112 chr2:234176609 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.6 0.42 2.29e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg27170947 chr2:26402098 FAM59B -1.0 -17.53 -0.57 1.76e-56 Gut microbiome composition (summer); BRCA cis rs495337 0.760 rs13040201 chr20:48536349 T/C cg17835207 chr20:48524531 SPATA2 -0.69 -16.83 -0.55 7.01e-53 Psoriasis; BRCA cis rs4908760 0.965 rs10864353 chr1:8549716 A/G cg20416874 chr1:8611966 RERE -0.29 -8.27 -0.31 7.84e-16 Vitiligo; BRCA cis rs17685 0.753 rs9691174 chr7:75790405 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6088590 0.687 rs13044899 chr20:33287078 G/A cg24642439 chr20:33292090 TP53INP2 0.6 12.87 0.45 7.06e-34 Coronary artery disease; BRCA trans rs11039798 0.588 rs59777067 chr11:49015350 C/T cg03929089 chr4:120376271 NA 0.58 9.33 0.35 1.73e-19 Axial length; BRCA cis rs7945705 0.846 rs4929912 chr11:8816695 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -9.92 -0.37 1.17e-21 Hemoglobin concentration; BRCA cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg14847009 chr1:175162515 KIAA0040 -0.28 -10.43 -0.38 1.23e-23 Diastolic blood pressure; BRCA cis rs10851411 0.697 rs62022316 chr15:42770362 T/C cg21293051 chr15:42870591 STARD9 0.52 8.43 0.32 2.25e-16 Glucose homeostasis traits; BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 22.12 0.66 5.79e-81 Platelet count; BRCA cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.39 13.42 0.47 2.44e-36 Bipolar disorder; BRCA cis rs9811920 0.638 rs793471 chr3:99546335 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.74 -0.53 2.09e-47 Axial length; BRCA cis rs7582180 0.652 rs4851311 chr2:100980398 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.53 0.41 4.56e-28 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.918 rs1042365 chr4:100045500 G/T cg13256891 chr4:100009986 ADH5 -0.52 -9.77 -0.36 4.2e-21 Alcohol dependence; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg22907277 chr7:1156413 C7orf50 0.48 11.63 0.42 1.76e-28 Longevity;Endometriosis; BRCA cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg01028140 chr2:1542097 TPO -0.81 -15.95 -0.53 1.81e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9858542 1.000 rs34762726 chr3:49689210 G/A cg03060546 chr3:49711283 APEH -0.61 -12.35 -0.44 1.43e-31 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs8114671 0.967 rs2069952 chr20:33763951 C/T cg07148914 chr20:33460835 GGT7 0.38 8.03 0.3 4.77e-15 Height; BRCA cis rs1003719 0.788 rs4572679 chr21:38453227 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.07 0.49 2.27e-39 Eye color traits; BRCA cis rs60871478 0.636 rs4276575 chr7:900035 C/T cg05535760 chr7:792225 HEATR2 -0.67 -11.21 -0.41 9.41e-27 Cerebrospinal P-tau181p levels; BRCA cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11644478 chr21:40555479 PSMG1 0.84 19.13 0.6 7.75e-65 Cognitive function; BRCA cis rs208520 0.837 rs208489 chr6:66927584 G/A cg07460842 chr6:66804631 NA -0.9 -15.72 -0.53 2.51e-47 Exhaled nitric oxide output; BRCA cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg10523679 chr1:76189770 ACADM 0.73 12.57 0.45 1.59e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11955398 0.604 rs11951950 chr5:59876940 C/G cg02684056 chr5:59996105 DEPDC1B 0.35 8.33 0.31 5.12e-16 Intelligence (multi-trait analysis); BRCA trans rs634534 0.622 rs1192168 chr11:65730945 T/G cg17712092 chr4:129076599 LARP1B 0.49 11.86 0.42 1.75e-29 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg11764359 chr7:65958608 NA -0.68 -15.05 -0.51 4.69e-44 Aortic root size; BRCA cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg06145435 chr7:1022769 CYP2W1 -0.41 -7.92 -0.3 1.02e-14 Bronchopulmonary dysplasia; BRCA cis rs9291683 0.609 rs12507050 chr4:10007305 G/T cg00071950 chr4:10020882 SLC2A9 0.64 15.79 0.53 1.16e-47 Bone mineral density; BRCA cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.46 -10.51 -0.38 6.12e-24 IgG glycosylation; BRCA cis rs4423214 0.840 rs1792315 chr11:71165547 C/T cg05163923 chr11:71159392 DHCR7 -0.55 -11.13 -0.4 2.09e-26 Vitamin D levels; BRCA cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.89 -0.33 6.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg16145915 chr7:1198662 ZFAND2A -0.48 -10.88 -0.4 2.14e-25 Longevity;Endometriosis; BRCA cis rs11920090 0.932 rs10513685 chr3:170724390 A/G cg09710316 chr3:170744871 SLC2A2 -0.42 -8.4 -0.32 2.79e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs72799341 1.000 rs72799341 chr16:30936743 G/A cg02466173 chr16:30829666 NA -0.47 -8.69 -0.32 3.11e-17 Diastolic blood pressure; BRCA cis rs6005807 0.719 rs9625522 chr22:29045212 C/A cg12565055 chr22:29076175 TTC28 0.49 9.28 0.34 2.68e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs9790314 0.740 rs4856767 chr3:161004379 C/T cg04691961 chr3:161091175 C3orf57 -0.41 -10.07 -0.37 3.16e-22 Morning vs. evening chronotype; BRCA cis rs73001065 0.551 rs79954596 chr19:19548643 T/G cg03709012 chr19:19516395 GATAD2A 1.02 15.45 0.52 5.66e-46 LDL cholesterol; BRCA cis rs2239547 0.657 rs13072536 chr3:52861211 A/T cg11645453 chr3:52864694 ITIH4 0.49 11.98 0.43 5.43e-30 Schizophrenia; BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 8.48 0.32 1.52e-16 Platelet count; BRCA cis rs3741404 0.791 rs2282491 chr11:63918373 T/C cg18225595 chr11:63971243 STIP1 0.55 13.82 0.48 3.47e-38 Platelet count; BRCA cis rs2243480 0.708 rs781141 chr7:65438553 A/G cg18252515 chr7:66147081 NA -0.82 -11.95 -0.43 7.52e-30 Diabetic kidney disease; BRCA cis rs881375 1.000 rs7037140 chr9:123656327 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.02 0.4 5.41e-26 Rheumatoid arthritis; BRCA cis rs9790314 0.905 rs6441370 chr3:160993754 C/T cg04691961 chr3:161091175 C3orf57 -0.59 -14.41 -0.5 5.86e-41 Morning vs. evening chronotype; BRCA cis rs2204008 0.627 rs10878486 chr12:38148601 T/G cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.46e-22 Bladder cancer; BRCA cis rs57221529 0.766 rs72706610 chr5:561111 G/A cg09021430 chr5:549028 NA -0.7 -16.01 -0.54 9.52e-49 Lung disease severity in cystic fibrosis; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.64 13.58 0.47 4.41e-37 Lymphocyte counts; BRCA cis rs9527 0.590 rs7073323 chr10:104797423 A/C cg04362960 chr10:104952993 NT5C2 0.42 9.56 0.35 2.45e-20 Arsenic metabolism; BRCA cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg12373951 chr3:133503437 NA 0.53 12.26 0.44 3.44e-31 Iron status biomarkers; BRCA cis rs910316 0.763 rs175042 chr14:75470833 A/T cg23033748 chr14:75592666 NEK9 -0.33 -7.94 -0.3 9.21e-15 Height; BRCA cis rs7918232 1.000 rs7918232 chr10:27369162 A/G cg14240646 chr10:27532245 ACBD5 -0.66 -10.35 -0.38 2.64e-23 Breast cancer; BRCA cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg08999081 chr20:33150536 PIGU -0.44 -12.23 -0.44 4.57e-31 Glomerular filtration rate (creatinine); BRCA cis rs9467711 0.591 rs72834617 chr6:25999175 G/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.24 0.34 3.63e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs2153535 0.541 rs945304 chr6:8442892 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 8.21e-41 Motion sickness; BRCA trans rs2562456 0.755 rs1879234 chr19:21704479 T/G cg25042112 chr7:64838748 ZNF92 0.45 8.32 0.31 5.25e-16 Pain; BRCA trans rs9388451 0.839 rs3799711 chr6:126075313 C/T cg05039488 chr6:79577232 IRAK1BP1 0.5 11.8 0.42 3.25e-29 Brugada syndrome; BRCA cis rs875971 0.862 rs1860469 chr7:66106875 A/G cg11764359 chr7:65958608 NA -0.7 -14.79 -0.51 8.77e-43 Aortic root size; BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg00814883 chr7:100076585 TSC22D4 -0.53 -11.45 -0.41 1e-27 Platelet count; BRCA cis rs4481887 0.927 rs4453080 chr1:248474671 T/C cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg07606381 chr6:8435919 SLC35B3 0.64 13.88 0.48 1.69e-38 Motion sickness; BRCA cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 21.02 0.64 6.08e-75 Platelet count; BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg20607798 chr8:58055168 NA 0.59 8.96 0.33 3.59e-18 Developmental language disorder (linguistic errors); BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.61 11.77 0.42 4.22e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7903847 0.642 rs61863819 chr10:99142400 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.34 -0.31 4.51e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs1153858 1.000 rs11070453 chr15:45645154 C/G cg14582100 chr15:45693742 SPATA5L1 0.37 11.87 0.42 1.69e-29 Homoarginine levels; BRCA cis rs7264396 0.563 rs11698796 chr20:34248134 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.78 -0.39 5.32e-25 Total cholesterol levels; BRCA cis rs9420 0.528 rs7117896 chr11:57388551 G/A cg19752551 chr11:57585705 CTNND1 -0.37 -9.27 -0.34 2.84e-19 Schizophrenia; BRCA cis rs12472274 0.646 rs11677736 chr2:239087198 A/T cg17459225 chr2:239074497 NA 0.6 11.14 0.4 1.83e-26 Phospholipid levels (plasma); BRCA cis rs1707322 0.638 rs1416706 chr1:46602844 G/A cg06784218 chr1:46089804 CCDC17 -0.39 -8.73 -0.33 2.2e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1215050 0.755 rs811479 chr4:98727398 A/T cg05340658 chr4:99064831 C4orf37 0.45 10.41 0.38 1.45e-23 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs3733585 0.664 rs17245436 chr4:9958169 A/G cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.04e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7827545 1.000 rs6578234 chr8:135566363 A/G cg17885191 chr8:135476712 NA 0.44 8.51 0.32 1.27e-16 Hypertension (SNP x SNP interaction); BRCA cis rs6582630 0.577 rs12312748 chr12:38343326 T/C cg26384229 chr12:38710491 ALG10B -0.41 -9.43 -0.35 7.55e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg22105103 chr4:187893119 NA 0.38 11.85 0.42 2.08e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg26314531 chr2:26401878 FAM59B -0.88 -15.45 -0.52 5.59e-46 Gut microbiome composition (summer); BRCA cis rs35110281 0.641 rs4818858 chr21:45083097 C/T cg04455712 chr21:45112962 RRP1B -0.45 -11.04 -0.4 4.73e-26 Mean corpuscular volume; BRCA cis rs7246967 0.673 rs73022713 chr19:22876222 G/C cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg20503657 chr10:835505 NA 1.3 21.62 0.65 3.08e-78 Eosinophil percentage of granulocytes; BRCA cis rs17376456 0.877 rs7701974 chr5:93311417 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.82 0.6 3.54e-63 Diabetic retinopathy; BRCA cis rs7246657 0.722 rs2909093 chr19:38199462 T/C cg18154014 chr19:37997991 ZNF793 -0.51 -9.61 -0.36 1.69e-20 Coronary artery calcification; BRCA cis rs701145 0.585 rs357473 chr3:153895147 C/T cg17054900 chr3:154042577 DHX36 0.57 9.49 0.35 4.51e-20 Coronary artery disease; BRCA cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg20219911 chr3:52813652 ITIH1 0.3 8.31 0.31 5.6e-16 Intelligence (multi-trait analysis); BRCA cis rs6694270 0.529 rs4076925 chr1:19113026 C/T cg19637330 chr1:19110922 NA 0.46 8.31 0.31 5.87e-16 Drug-induced liver injury (nitrofurantoin); BRCA trans rs9325144 0.534 rs4882350 chr12:38686979 A/G cg23762105 chr12:34175262 ALG10 -0.36 -9.01 -0.34 2.34e-18 Morning vs. evening chronotype; BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg08805041 chr16:621841 PIGQ -0.32 -8.83 -0.33 1.01e-17 Height; BRCA cis rs1448094 0.512 rs11117060 chr12:86250788 G/T cg19622623 chr12:86230825 RASSF9 0.33 9.43 0.35 7.68e-20 Major depressive disorder; BRCA trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg03929089 chr4:120376271 NA -0.79 -17.06 -0.56 4.75e-54 Height; BRCA cis rs73086581 0.947 rs55794220 chr20:3956402 C/T cg02187196 chr20:3869020 PANK2 0.53 9.55 0.35 2.71e-20 Response to antidepressants in depression; BRCA trans rs3857536 0.785 rs6455089 chr6:66944733 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.84 -0.3 1.89e-14 Blood trace element (Cu levels); BRCA cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs1493916 0.837 rs8088362 chr18:31413016 A/G cg27147174 chr7:100797783 AP1S1 -0.42 -8.5 -0.32 1.37e-16 Life satisfaction; BRCA cis rs11229555 0.609 rs12273635 chr11:58186327 T/C cg15696309 chr11:58395628 NA -0.45 -9.71 -0.36 7.23e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4819052 0.851 rs2838844 chr21:46670733 A/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.53 0.35 3.31e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2304069 0.954 rs216127 chr5:149428890 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.78 15.22 0.52 7.53e-45 HIV-1 control; BRCA cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg08975724 chr8:8085496 FLJ10661 -0.54 -11.25 -0.41 6.59e-27 Neuroticism; BRCA cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg17691542 chr6:26056736 HIST1H1C 0.56 12.12 0.43 1.46e-30 Height; BRCA cis rs11997175 0.740 rs6991071 chr8:33814103 G/A ch.8.33884649F chr8:33765107 NA 0.42 10.22 0.37 8.56e-23 Body mass index; BRCA trans rs9291683 0.546 rs6820188 chr4:10051655 C/T cg26043149 chr18:55253948 FECH 0.4 8.7 0.33 2.79e-17 Bone mineral density; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg04025307 chr7:1156635 C7orf50 0.48 8.33 0.31 5.01e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17401966 1.000 rs3748578 chr1:10420918 A/G cg03954927 chr1:10346856 KIF1B -0.45 -12.85 -0.45 8.82e-34 Hepatocellular carcinoma; BRCA cis rs67311347 1.000 rs2276870 chr3:40499182 C/T cg01475735 chr3:40494733 NA 0.48 9.85 0.36 2.02e-21 Renal cell carcinoma; BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg16606324 chr3:10149918 C3orf24 0.49 9.81 0.36 2.97e-21 Alzheimer's disease; BRCA cis rs870825 0.616 rs4437299 chr4:185643223 T/A cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg03929089 chr4:120376271 NA -0.45 -8.31 -0.31 5.66e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs4363385 0.720 rs883810 chr1:152941345 T/C cg25856811 chr1:152973957 SPRR3 -0.31 -8.02 -0.3 5.14e-15 Inflammatory skin disease; BRCA cis rs2637266 1.000 rs7073355 chr10:78354419 G/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg20607287 chr7:12443886 VWDE -0.58 -8.44 -0.32 2.17e-16 Coronary artery disease; BRCA cis rs738322 0.718 rs2899297 chr22:38594668 A/G cg25457927 chr22:38595422 NA -0.5 -21.46 -0.65 2.33e-77 Cutaneous nevi; BRCA cis rs6545883 0.965 rs10186325 chr2:61757721 G/T cg15711740 chr2:61764176 XPO1 -0.53 -13.72 -0.48 9.74e-38 Tuberculosis; BRCA cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg05347473 chr6:146136440 FBXO30 0.4 8.11 0.31 2.64e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs8062405 0.964 rs11864107 chr16:28885931 T/C cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg17063962 chr7:91808500 NA 0.55 13.04 0.46 1.24e-34 Breast cancer; BRCA cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14240646 chr10:27532245 ACBD5 -0.62 -9.65 -0.36 1.21e-20 Breast cancer; BRCA cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg03264133 chr6:25882463 NA 0.41 8.8 0.33 1.26e-17 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs17374627 chr5:93296306 C/T cg21475434 chr5:93447410 FAM172A 0.7 9.3 0.35 2.22e-19 Diabetic retinopathy; BRCA trans rs6089829 0.851 rs6089827 chr20:61668845 C/T cg17470723 chr8:74884337 TCEB1 0.4 8.68 0.32 3.36e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg11062466 chr8:58055876 NA -0.48 -8.42 -0.32 2.55e-16 Developmental language disorder (linguistic errors); BRCA cis rs6062302 0.522 rs6089929 chr20:62219679 C/T cg16989086 chr20:62203971 PRIC285 0.54 9.07 0.34 1.41e-18 Glioblastoma; BRCA cis rs4363385 0.747 rs2339496 chr1:152970719 C/T cg21543102 chr1:152974771 SPRR3 -0.3 -8.52 -0.32 1.18e-16 Inflammatory skin disease; BRCA trans rs6076960 0.598 rs3905168 chr20:6226752 C/T cg17788362 chr6:86352627 SYNCRIP 0.4 8.09 0.3 3.03e-15 Smooth-surface caries; BRCA cis rs72945132 0.825 rs72947052 chr11:70188575 A/G cg13802316 chr11:70253460 CTTN -0.56 -8.37 -0.31 3.65e-16 Coronary artery disease; BRCA cis rs9828933 0.752 rs28675788 chr3:63942188 C/G cg16258503 chr3:63850278 ATXN7;THOC7 -0.75 -11.7 -0.42 8.89e-29 Type 2 diabetes; BRCA cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg17366294 chr4:99064904 C4orf37 0.52 11.54 0.42 4.23e-28 Colonoscopy-negative controls vs population controls; BRCA trans rs3780486 0.522 rs10217770 chr9:33146393 C/A cg20290983 chr6:43655470 MRPS18A 0.8 20.54 0.63 2.25e-72 IgG glycosylation; BRCA cis rs61931739 0.534 rs2636072 chr12:34062386 C/T cg06521331 chr12:34319734 NA -0.63 -12.48 -0.44 3.99e-32 Morning vs. evening chronotype; BRCA cis rs57590327 0.503 rs2049415 chr3:81901887 A/T cg07356753 chr3:81810745 GBE1 -0.44 -10.06 -0.37 3.41e-22 Extraversion; BRCA cis rs4919087 0.926 rs7072078 chr10:99026509 G/A cg25902810 chr10:99078978 FRAT1 0.38 8.12 0.31 2.49e-15 Monocyte count; BRCA cis rs2243480 0.901 rs2900904 chr7:65204264 C/G cg18252515 chr7:66147081 NA -0.91 -13.01 -0.46 1.68e-34 Diabetic kidney disease; BRCA cis rs8017423 1.000 rs4900028 chr14:90685594 C/T cg14092571 chr14:90743983 NA -0.34 -8.12 -0.31 2.36e-15 Mortality in heart failure; BRCA cis rs6460942 0.597 rs4719315 chr7:12528634 A/G cg06484146 chr7:12443880 VWDE -0.58 -7.8 -0.3 2.45e-14 Coronary artery disease; BRCA cis rs7851660 0.967 rs4743134 chr9:100598568 C/A cg13688889 chr9:100608707 NA -0.36 -8.61 -0.32 5.84e-17 Strep throat; BRCA cis rs3806843 0.676 rs1583005 chr5:140031537 G/A cg21161173 chr5:140098174 VTRNA1-2 0.31 7.83 0.3 2e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs9790314 0.663 rs7630674 chr3:160813597 G/A cg04691961 chr3:161091175 C3orf57 -0.36 -8.07 -0.3 3.39e-15 Morning vs. evening chronotype; BRCA cis rs2832077 0.943 rs11702320 chr21:30195251 A/T cg08807101 chr21:30365312 RNF160 -0.47 -8.07 -0.3 3.56e-15 Cognitive test performance; BRCA cis rs9368481 0.761 rs7775041 chr6:27009512 T/A cg12292205 chr6:26970375 C6orf41 -0.71 -16.7 -0.55 3.2e-52 Autism spectrum disorder or schizophrenia; BRCA cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.55 -0.32 8.89e-17 Intelligence (multi-trait analysis); BRCA cis rs936229 1.000 rs936229 chr15:75132319 A/G cg14664628 chr15:75095509 CSK -0.89 -24.26 -0.69 1.12e-92 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs600806 0.815 rs10858089 chr1:109926828 T/C cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs243505 0.559 rs1558420 chr7:148480114 G/T cg09806900 chr7:148480153 CUL1 0.55 11.29 0.41 4.44e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12142240 0.698 rs17357628 chr1:46808462 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg03188948 chr7:1209495 NA 0.49 9.04 0.34 1.9e-18 Longevity;Endometriosis; BRCA cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs11711311 1.000 rs2603789 chr3:113470479 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.33 8.68 0.32 3.23e-17 IgG glycosylation; BRCA cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs9325144 0.600 rs10785615 chr12:38733627 G/C cg26384229 chr12:38710491 ALG10B 0.49 12.32 0.44 1.99e-31 Morning vs. evening chronotype; BRCA cis rs698833 0.624 rs7564087 chr2:44693647 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 9.19 0.34 5.54e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7772486 0.754 rs702323 chr6:146008274 A/G cg23711669 chr6:146136114 FBXO30 -0.69 -16.01 -0.54 8.99e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg18758796 chr5:131593413 PDLIM4 0.35 9.29 0.34 2.43e-19 Breast cancer; BRCA cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg12927641 chr6:109611667 NA 0.42 11.14 0.4 1.87e-26 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs28830936 0.510 rs2412640 chr15:42124082 C/T cg17847044 chr15:42102381 MAPKBP1 0.46 17.15 0.56 1.64e-54 Diastolic blood pressure; BRCA cis rs9790314 0.521 rs1376122 chr3:161087857 A/G cg03342759 chr3:160939853 NMD3 -0.56 -11.93 -0.43 9.38e-30 Morning vs. evening chronotype; BRCA cis rs2180341 0.855 rs4308584 chr6:127714874 A/G cg24812749 chr6:127587940 RNF146 0.69 15.59 0.53 1.08e-46 Breast cancer; BRCA cis rs752010 0.934 rs11210503 chr1:42101134 A/G cg06885757 chr1:42089581 HIVEP3 0.24 8.72 0.33 2.35e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs45509595 0.822 rs200484 chr6:27775674 A/G cg26587870 chr6:27730563 NA -0.52 -8.04 -0.3 4.31e-15 Breast cancer; BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg03188948 chr7:1209495 NA 0.74 12.12 0.43 1.47e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg22963979 chr7:1858916 MAD1L1 -0.38 -7.95 -0.3 8.35e-15 Bipolar disorder and schizophrenia; BRCA cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.51 12.11 0.43 1.57e-30 Response to bleomycin (chromatid breaks); BRCA cis rs6066825 0.555 rs717709 chr20:47305959 G/A cg18078177 chr20:47281410 PREX1 0.39 9.66 0.36 1.09e-20 Colorectal cancer; BRCA cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.53 -11.3 -0.41 4.04e-27 IgG glycosylation; BRCA cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg05283184 chr6:79620031 NA -0.42 -11.16 -0.4 1.45e-26 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg08885076 chr2:99613938 TSGA10 -0.53 -12.03 -0.43 3.45e-30 Chronic sinus infection; BRCA cis rs698833 0.926 rs786622 chr2:44606598 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.9 0.4 1.7e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2880765 0.743 rs4551990 chr15:86015287 A/C cg10818794 chr15:86012489 AKAP13 -0.31 -8.46 -0.32 1.84e-16 Coronary artery disease; BRCA cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg21132104 chr15:45694354 SPATA5L1 0.71 15.58 0.52 1.28e-46 Homoarginine levels; BRCA cis rs7552404 0.731 rs11161845 chr1:76367559 T/C cg10523679 chr1:76189770 ACADM 0.7 12.24 0.44 4.12e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9399135 0.967 rs11754783 chr6:135347661 T/A cg24558204 chr6:135376177 HBS1L 0.45 12.41 0.44 8.13e-32 Red blood cell count; BRCA cis rs3008870 1.000 rs58680688 chr1:67443751 C/G cg08660285 chr1:67390436 MIER1;WDR78 -0.98 -21.52 -0.65 1.07e-77 Lymphocyte percentage of white cells; BRCA cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg21770322 chr7:97807741 LMTK2 0.44 11.54 0.42 3.92e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.86 -0.3 1.7e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs534126 0.778 rs10256011 chr7:142936243 G/A cg22531018 chr7:142981779 TMEM139 0.48 10.84 0.39 3.02e-25 Cancer; BRCA cis rs6120849 0.754 rs6088686 chr20:33623437 C/T cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs7945718 0.967 rs4415740 chr11:12783911 C/T cg25843174 chr11:12811716 TEAD1 0.23 8.81 0.33 1.2e-17 Educational attainment (years of education); BRCA cis rs12586317 0.547 rs28569331 chr14:35473584 T/C cg16230307 chr14:35515116 FAM177A1 0.73 15.28 0.52 3.85e-45 Psoriasis; BRCA cis rs7945718 0.934 rs10831905 chr11:12776467 C/T cg25843174 chr11:12811716 TEAD1 -0.24 -8.97 -0.33 3.34e-18 Educational attainment (years of education); BRCA trans rs4650994 1.000 rs4650994 chr1:178515312 A/G cg05059571 chr16:84539110 KIAA1609 0.41 9.44 0.35 6.88e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs244731 0.959 rs7721671 chr5:176630984 A/G cg16006841 chr5:176797999 RGS14 -0.69 -11.1 -0.4 2.59e-26 Urate levels in lean individuals; BRCA trans rs6951245 0.872 rs11768486 chr7:1101290 C/A cg13565492 chr6:43139072 SRF -0.79 -10.95 -0.4 1.07e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4285028 0.747 rs11923248 chr3:121566498 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.89 -15.88 -0.53 4.04e-48 Multiple sclerosis; BRCA cis rs1008375 0.931 rs6831211 chr4:17697009 G/A cg16339924 chr4:17578868 LAP3 0.58 14.02 0.49 3.9e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg19077165 chr18:44547161 KATNAL2 -0.6 -13.52 -0.47 7.93e-37 Personality dimensions; BRCA cis rs4919087 1.000 rs11189132 chr10:99086195 G/C cg25902810 chr10:99078978 FRAT1 -0.45 -9.49 -0.35 4.33e-20 Monocyte count; BRCA cis rs9487051 0.735 rs351754 chr6:109537553 A/G cg21918786 chr6:109611834 NA 0.36 9.61 0.36 1.68e-20 Reticulocyte fraction of red cells; BRCA trans rs3780486 0.846 rs7864705 chr9:33140352 A/C cg04842962 chr6:43655489 MRPS18A 1.12 39.16 0.84 5.65e-172 IgG glycosylation; BRCA cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.99 -0.34 2.75e-18 Alzheimer's disease (late onset); BRCA cis rs875971 0.862 rs13536 chr7:66019190 G/A cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg12011299 chr4:100065546 ADH4 0.51 11.77 0.42 4.27e-29 Alcohol dependence; BRCA cis rs13256369 0.951 rs12679360 chr8:8566269 G/T cg00074818 chr8:8560427 CLDN23 -0.36 -7.83 -0.3 2.1e-14 Obesity-related traits; BRCA cis rs1580019 0.961 rs1580021 chr7:32497702 T/G cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.31 0.54 2.85e-50 Cognitive ability; BRCA cis rs6860806 0.507 rs272854 chr5:131688017 C/T cg24060327 chr5:131705240 SLC22A5 -0.59 -10.85 -0.39 2.79e-25 Breast cancer; BRCA cis rs9733 0.596 rs56058687 chr1:150635066 C/T cg17724175 chr1:150552817 MCL1 0.26 8.54 0.32 9.94e-17 Tonsillectomy; BRCA cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg08917208 chr2:24149416 ATAD2B 0.91 13.38 0.47 3.55e-36 Lymphocyte counts; BRCA cis rs801193 0.569 rs7782587 chr7:66166472 C/T cg18876405 chr7:65276391 NA 0.47 10.73 0.39 8.55e-25 Aortic root size; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg16145915 chr7:1198662 ZFAND2A -0.4 -9.44 -0.35 6.8e-20 Longevity;Endometriosis; BRCA trans rs66887589 0.616 rs6843509 chr4:120220196 G/A cg25214090 chr10:38739885 LOC399744 0.37 8.58 0.32 7.01e-17 Diastolic blood pressure; BRCA cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg26818010 chr10:134567672 INPP5A -0.77 -15.31 -0.52 2.62e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2204008 0.774 rs11495721 chr12:38337224 A/C cg26384229 chr12:38710491 ALG10B 0.7 16.01 0.53 9.85e-49 Bladder cancer; BRCA cis rs4073582 0.576 rs556595 chr11:66058082 T/G cg14036092 chr11:66035641 RAB1B 0.37 9.65 0.36 1.15e-20 Gout; BRCA cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg05535760 chr7:792225 HEATR2 0.87 14.89 0.51 2.79e-43 Cerebrospinal P-tau181p levels; BRCA cis rs10782582 0.632 rs11810154 chr1:76239973 C/G cg03433033 chr1:76189801 ACADM -0.41 -8.24 -0.31 9.93e-16 Daytime sleep phenotypes; BRCA cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg25173405 chr17:45401733 C17orf57 -0.54 -11.12 -0.4 2.26e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2576037 0.523 rs4890705 chr18:44509758 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 13.91 0.48 1.32e-38 Personality dimensions; BRCA cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg00074818 chr8:8560427 CLDN23 0.38 8.26 0.31 8.4e-16 Obesity-related traits; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.79 -14.81 -0.51 6.91e-43 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs61931739 0.500 rs11053208 chr12:34460029 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.91 0.33 5.14e-18 Morning vs. evening chronotype; BRCA cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg12756686 chr19:29218302 NA 0.57 11.01 0.4 6.44e-26 Methadone dose in opioid dependence; BRCA cis rs7618915 0.501 rs34157897 chr3:52716937 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.89 0.45 6.08e-34 Bipolar disorder; BRCA cis rs9986765 1.000 rs4565384 chr7:142811564 C/A cg21852589 chr7:142981689 TMEM139 0.57 9.68 0.36 8.95e-21 Cancer;Dermatomyositis; BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 -0.38 -8.43 -0.32 2.26e-16 Tonsillectomy; BRCA cis rs7246657 0.722 rs2909102 chr19:38167364 C/T cg14683738 chr19:37701593 ZNF585B -0.47 -7.96 -0.3 7.99e-15 Coronary artery calcification; BRCA cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg06784218 chr1:46089804 CCDC17 0.51 12.3 0.44 2.3e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg10523679 chr1:76189770 ACADM 0.77 15.94 0.53 2.03e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg13736514 chr6:26305472 NA -0.34 -11.71 -0.42 8.23e-29 Educational attainment; BRCA cis rs752010 0.967 rs6681441 chr1:42098321 G/A cg06885757 chr1:42089581 HIVEP3 0.23 8.33 0.31 4.94e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7587476 0.505 rs777323 chr2:215738485 A/G cg04004882 chr2:215674386 BARD1 -0.53 -9.63 -0.36 1.35e-20 Neuroblastoma; BRCA cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 4e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs312273 0.658 rs1372544 chr12:41353559 T/C cg17827154 chr12:41323612 CNTN1 -0.39 -10.0 -0.37 5.71e-22 Bipolar disorder; BRCA cis rs2617583 0.530 rs10060889 chr5:1456803 A/G cg07148919 chr5:1466943 LPCAT1 -0.37 -7.89 -0.3 1.31e-14 Breast cancer; BRCA cis rs705471 0.762 rs555978 chr10:3662558 G/A cg14308648 chr10:3568949 NA 0.39 10.09 0.37 2.61e-22 Capecitabine sensitivity; BRCA cis rs9443645 0.869 rs9343848 chr6:79621101 C/T cg05283184 chr6:79620031 NA -0.44 -11.15 -0.4 1.62e-26 Intelligence (multi-trait analysis); BRCA cis rs769267 1.000 rs3764567 chr19:19440066 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -9.17 -0.34 6.23e-19 Tonsillectomy; BRCA cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs7746199 0.736 rs17749927 chr6:27669976 A/G cg01620082 chr3:125678407 NA -0.92 -10.33 -0.38 2.97e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs8073060 0.586 rs9649 chr17:34050934 C/T cg19694781 chr19:47549865 TMEM160 1.07 20.64 0.63 6.34e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs4650994 1.000 rs10913571 chr1:178526648 A/T cg05059571 chr16:84539110 KIAA1609 -0.41 -9.22 -0.34 4.12e-19 HDL cholesterol levels;HDL cholesterol; BRCA cis rs7959452 0.590 rs10878974 chr12:69781528 C/G cg20891283 chr12:69753455 YEATS4 0.73 21.68 0.65 1.5e-78 Blood protein levels; BRCA cis rs2749592 0.531 rs1208559 chr10:38221370 T/C cg00409905 chr10:38381863 ZNF37A 0.48 9.36 0.35 1.31e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6977660 0.714 rs728156 chr7:19826309 G/C cg05791153 chr7:19748676 TWISTNB 0.58 10.92 0.4 1.41e-25 Thyroid stimulating hormone; BRCA cis rs16854884 0.657 rs2099543 chr3:143742164 C/T cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA trans rs9929218 0.953 rs3114411 chr16:68734591 G/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.86 16.56 0.55 1.59e-51 Colorectal cancer; BRCA cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg08048268 chr3:133502702 NA -0.32 -8.11 -0.31 2.66e-15 Iron status biomarkers; BRCA cis rs7586879 0.828 rs13387053 chr2:25103025 G/A cg04586622 chr2:25135609 ADCY3 0.4 9.48 0.35 4.77e-20 Body mass index; BRCA trans rs61931739 0.517 rs12816252 chr12:34067693 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.37 0.35 1.19e-19 Morning vs. evening chronotype; BRCA cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg09035930 chr12:129282057 SLC15A4 0.56 16.77 0.55 1.35e-52 Systemic lupus erythematosus; BRCA cis rs9325144 0.624 rs7979541 chr12:39129679 T/C cg26384229 chr12:38710491 ALG10B -0.45 -10.91 -0.4 1.54e-25 Morning vs. evening chronotype; BRCA cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg00990874 chr7:1149470 C7orf50 -0.59 -11.87 -0.42 1.7e-29 Bronchopulmonary dysplasia; BRCA cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.3e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg20701182 chr2:24300061 SF3B14 0.6 8.68 0.32 3.21e-17 Lymphocyte counts; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg08132940 chr7:1081526 C7orf50 -0.57 -8.67 -0.32 3.65e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26314531 chr2:26401878 FAM59B -0.79 -12.72 -0.45 3.52e-33 Gut microbiome composition (summer); BRCA cis rs35306767 0.855 rs11253499 chr10:944090 A/C cg26597838 chr10:835615 NA 1.02 18.05 0.58 3.74e-59 Eosinophil percentage of granulocytes; BRCA cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg27129171 chr3:47204927 SETD2 -0.73 -17.74 -0.57 1.55e-57 Colorectal cancer; BRCA cis rs12474201 0.928 rs1109380 chr2:46924490 G/T cg06386533 chr2:46925753 SOCS5 0.87 19.2 0.6 3.39e-65 Height; BRCA cis rs243505 0.898 rs243544 chr7:148402710 T/A cg09806900 chr7:148480153 CUL1 -0.4 -8.18 -0.31 1.56e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs919433 0.679 rs1902249 chr2:198521356 T/C cg00792783 chr2:198669748 PLCL1 0.39 9.02 0.34 2.24e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg03709012 chr19:19516395 GATAD2A -0.75 -16.72 -0.55 2.46e-52 Tonsillectomy; BRCA trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg01114163 chr5:1856713 NA -0.35 -7.84 -0.3 1.92e-14 Cardiovascular disease risk factors; BRCA cis rs6733011 0.508 rs13004700 chr2:99527568 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -9.66 -0.36 1.1e-20 Bipolar disorder; BRCA cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg00898013 chr13:113819073 PROZ -0.38 -9.45 -0.35 6.55e-20 Platelet distribution width; BRCA cis rs56235845 0.964 rs4075958 chr5:176784512 A/G cg17509989 chr5:176798049 RGS14 -0.9 -17.3 -0.56 2.86e-55 Hemoglobin concentration;Hematocrit; BRCA cis rs7903847 0.667 rs7096801 chr10:99140969 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10754283 0.901 rs4520403 chr1:90112840 T/G cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.19e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs7786877 0.500 rs2272572 chr7:100285888 C/T cg20848291 chr7:100343083 ZAN -0.6 -12.31 -0.44 2.13e-31 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6456156 0.586 rs7761977 chr6:167485678 A/G cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg05552183 chr6:42928497 GNMT 0.68 15.48 0.52 4.03e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.42 0.41 1.32e-27 Coronary artery disease; BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.83 -12.47 -0.44 4.25e-32 Platelet count; BRCA trans rs35110281 0.805 rs2838330 chr21:45023876 T/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.59 0.32 6.63e-17 Mean corpuscular volume; BRCA cis rs829883 0.659 rs12366275 chr12:98920276 G/C cg25150519 chr12:98850993 NA -0.52 -9.44 -0.35 6.93e-20 Colorectal adenoma (advanced); BRCA cis rs9372253 1.000 rs11153232 chr6:110716252 G/T cg19196401 chr6:110721138 DDO 0.37 9.23 0.34 3.81e-19 Platelet distribution width; BRCA cis rs9790314 1.000 rs9850455 chr3:161017192 G/A cg04691961 chr3:161091175 C3orf57 -0.52 -12.94 -0.46 3.68e-34 Morning vs. evening chronotype; BRCA cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg10802521 chr3:52805072 NEK4 -0.32 -8.31 -0.31 5.79e-16 Bipolar disorder; BRCA cis rs2249625 0.564 rs2496496 chr6:72884053 A/G cg18830697 chr6:72922368 RIMS1 -0.63 -14.36 -0.49 9.82e-41 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 13.36 0.47 4.3e-36 Lymphocyte counts; BRCA cis rs10197940 0.578 rs6718372 chr2:152345871 C/G cg06191203 chr2:152266755 RIF1 -0.28 -8.11 -0.31 2.57e-15 Lung cancer; BRCA cis rs953387 0.910 rs7568884 chr2:136928320 A/G cg05194412 chr2:137003533 NA 0.35 8.11 0.31 2.51e-15 Arthritis (juvenile idiopathic); BRCA cis rs10046574 0.831 rs10227931 chr7:135084601 C/T cg27474649 chr7:135195673 CNOT4 0.58 8.3 0.31 6.41e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg19626725 chr5:178986131 RUFY1 0.36 11.04 0.4 4.54e-26 Lung cancer; BRCA trans rs11098499 0.913 rs11098496 chr4:120167466 C/G cg25214090 chr10:38739885 LOC399744 0.48 10.62 0.39 2.18e-24 Corneal astigmatism; BRCA cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.88 0.76 2.12e-123 Cognitive ability; BRCA cis rs12579753 0.871 rs35801863 chr12:82238818 A/T cg07988820 chr12:82153109 PPFIA2 -0.64 -10.39 -0.38 1.77e-23 Resting heart rate; BRCA cis rs1401999 0.898 rs9876143 chr3:183731362 C/G cg01324343 chr3:183735012 ABCC5 0.83 20.89 0.64 3.1e-74 Anterior chamber depth; BRCA cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg03146154 chr1:46216737 IPP 0.54 12.19 0.43 7.22e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg06636001 chr8:8085503 FLJ10661 0.51 10.77 0.39 5.84e-25 Neuroticism; BRCA cis rs6700896 0.931 rs1892534 chr1:66105944 C/T cg04111102 chr1:66153794 NA 0.32 8.03 0.3 4.77e-15 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs875971 0.964 rs2161065 chr7:65932905 A/G cg11764359 chr7:65958608 NA 0.79 19.31 0.61 8.49e-66 Aortic root size; BRCA cis rs858239 0.899 rs1881203 chr7:23292808 T/C cg23682824 chr7:23144976 KLHL7 0.33 8.45 0.32 1.96e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs8005677 1.000 rs1951119 chr14:23388326 A/C cg01529538 chr14:23388837 RBM23 0.42 11.48 0.41 7.01e-28 Cognitive ability (multi-trait analysis); BRCA cis rs2880765 0.835 rs6497206 chr15:86029225 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.23e-17 Coronary artery disease; BRCA cis rs75920871 0.660 rs12271161 chr11:116979911 C/T cg01368799 chr11:117014884 PAFAH1B2 -0.54 -9.86 -0.36 1.92e-21 Subjective well-being; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg13047869 chr3:10149882 C3orf24 0.55 10.3 0.38 4.02e-23 Alzheimer's disease; BRCA cis rs1505368 0.836 rs10201067 chr2:213284411 A/G cg20637307 chr2:213403960 ERBB4 -0.4 -9.6 -0.36 1.72e-20 Symmetrical dimethylarginine levels; BRCA cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg02733842 chr7:1102375 C7orf50 -0.64 -11.97 -0.43 6.34e-30 Bronchopulmonary dysplasia; BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg22800045 chr5:56110881 MAP3K1 0.69 12.96 0.46 2.81e-34 Initial pursuit acceleration; BRCA cis rs6121246 0.609 rs6060955 chr20:30385071 A/G cg21427119 chr20:30132790 HM13 -0.35 -7.92 -0.3 1.08e-14 Mean corpuscular hemoglobin; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg04025307 chr7:1156635 C7orf50 0.58 9.0 0.34 2.5e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs6827516 chr4:98971740 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs7937682 0.632 rs11214015 chr11:111719417 A/T cg09085632 chr11:111637200 PPP2R1B -0.73 -15.78 -0.53 1.26e-47 Primary sclerosing cholangitis; BRCA cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg06552810 chr11:31128660 NA -0.39 -8.6 -0.32 6.15e-17 Red blood cell count; BRCA trans rs61931739 0.534 rs11053014 chr12:34103519 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.16 0.49 8.91e-40 Morning vs. evening chronotype; BRCA cis rs4629710 0.592 rs13195700 chr6:131585299 C/T cg12606694 chr6:131520996 AKAP7 0.54 11.53 0.41 4.64e-28 Multiple myeloma (IgH translocation); BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg27170947 chr2:26402098 FAM59B 0.94 17.46 0.57 4e-56 Gut microbiome composition (summer); BRCA cis rs4363385 0.693 rs2339487 chr1:152983528 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.74 -0.36 5.18e-21 Inflammatory skin disease; BRCA cis rs2425143 1.000 rs11699793 chr20:34271574 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.88 -0.33 6.56e-18 Blood protein levels; BRCA cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.23 0.41 7.91e-27 Monocyte percentage of white cells; BRCA trans rs634534 0.622 rs501353 chr11:65739549 T/G cg17712092 chr4:129076599 LARP1B 0.5 12.17 0.43 8.8e-31 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs672059 0.966 rs689375 chr1:183160973 A/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.46e-17 Hypertriglyceridemia; BRCA cis rs2204008 0.658 rs11181310 chr12:38315963 C/A cg26384229 chr12:38710491 ALG10B 0.74 17.05 0.56 5.56e-54 Bladder cancer; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg04013093 chr6:42928303 GNMT -0.28 -8.79 -0.33 1.4e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg24531977 chr5:56204891 C5orf35 -0.89 -18.88 -0.6 1.64e-63 Initial pursuit acceleration; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs3806701 0.619 rs6442008 chr3:46645753 C/T cg16875182 chr3:46619291 LRRC2;TDGF1 -0.44 -8.53 -0.32 1.08e-16 Blood protein levels; BRCA cis rs1153858 1.000 rs3759899 chr15:45655903 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.69 0.42 9.8e-29 Homoarginine levels; BRCA trans rs877282 0.755 rs2486578 chr10:785227 C/T cg22713356 chr15:30763199 NA -1.1 -21.66 -0.65 1.86e-78 Uric acid levels; BRCA trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg13010199 chr12:38710504 ALG10B 0.49 9.62 0.36 1.5e-20 Morning vs. evening chronotype; BRCA cis rs7586879 0.681 rs28836469 chr2:25117215 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.26e-28 Body mass index; BRCA cis rs7264396 0.690 rs17093156 chr20:34438583 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.45 -0.52 5.35e-46 Total cholesterol levels; BRCA cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg27170947 chr2:26402098 FAM59B -0.47 -8.55 -0.32 8.99e-17 Gut microbiome composition (summer); BRCA cis rs72634258 0.796 rs6703955 chr1:8165975 C/G cg00042356 chr1:8021962 PARK7 -0.54 -9.27 -0.34 2.84e-19 Inflammatory bowel disease; BRCA cis rs9381040 0.655 rs9381029 chr6:41026453 G/C cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.31 -0.35 2.06e-19 Alzheimer's disease (late onset); BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.01 22.16 0.66 3.76e-81 Gut microbiome composition (summer); BRCA cis rs6745190 0.557 rs13031518 chr2:181991759 A/G cg00481216 chr2:181971175 NA 0.47 8.89 0.33 6.33e-18 White blood cell count; BRCA cis rs73001065 0.636 rs56241616 chr19:19506092 C/T cg03709012 chr19:19516395 GATAD2A 1.04 15.4 0.52 9.25e-46 LDL cholesterol; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg16132339 chr22:24313637 DDTL;DDT 0.35 7.92 0.3 1.07e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg04455712 chr21:45112962 RRP1B 0.41 11.06 0.4 3.77e-26 Mean corpuscular volume; BRCA cis rs2991971 0.869 rs2453404 chr1:46014735 A/G cg24296786 chr1:45957014 TESK2 0.6 14.53 0.5 1.52e-41 High light scatter reticulocyte count; BRCA cis rs2832191 0.692 rs2776240 chr21:30310639 C/T cg24692254 chr21:30365293 RNF160 0.74 20.32 0.63 3.42e-71 Dental caries; BRCA cis rs7267979 0.932 rs449370 chr20:25451180 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.33 -0.35 1.7e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11098499 0.821 rs28665282 chr4:120384186 C/T cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.6 11.79 0.42 3.56e-29 Multiple sclerosis; BRCA cis rs41005 1.000 rs41003 chr2:8111772 A/C cg03155496 chr2:8117019 LOC339788 0.57 15.33 0.52 2.21e-45 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -8.95 -0.33 3.93e-18 Total body bone mineral density; BRCA trans rs11252926 0.604 rs12359454 chr10:568081 T/C cg00953403 chr17:74099816 EXOC7 -0.45 -8.07 -0.3 3.37e-15 Psychosis in Alzheimer's disease; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg24846343 chr22:24311635 DDTL -0.56 -14.35 -0.49 1.08e-40 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2046867 0.862 rs2322612 chr3:72830058 A/G cg25664220 chr3:72788482 NA -0.46 -10.07 -0.37 3.19e-22 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA trans rs4332037 0.539 rs1533827 chr7:2074290 A/G cg25206134 chr2:45395956 NA -0.52 -8.89 -0.33 6.41e-18 Bipolar disorder; BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg16606324 chr3:10149918 C3orf24 -0.5 -10.14 -0.37 1.61e-22 Alzheimer's disease; BRCA cis rs4727027 0.901 rs6943937 chr7:148869915 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 9.04 0.34 1.8e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13046373 0.508 rs1012969 chr21:31996108 G/A cg06468780 chr21:31798236 KRTAP13-3 0.33 8.26 0.31 8.39e-16 HDL cholesterol; BRCA cis rs9435341 0.930 rs2232015 chr1:107599258 A/T cg09367891 chr1:107599246 PRMT6 0.55 10.1 0.37 2.42e-22 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg27446573 chr6:127587934 RNF146 0.89 20.51 0.63 3.45e-72 Breast cancer; BRCA cis rs6963495 0.818 rs118134111 chr7:105161229 A/C cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA trans rs11039798 0.764 rs11040030 chr11:48800985 C/T cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs881375 0.678 rs10760125 chr9:123662590 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.61 0.42 1.98e-28 Rheumatoid arthritis; BRCA cis rs1506636 0.646 rs805778 chr7:123214655 C/T cg03229431 chr7:123269106 ASB15 -0.59 -12.65 -0.45 6.73e-33 Plateletcrit;Platelet count; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg23978390 chr7:1156363 C7orf50 -0.38 -8.52 -0.32 1.16e-16 Longevity;Endometriosis; BRCA cis rs2404602 0.684 rs8037847 chr15:76856551 C/T cg23625390 chr15:77176239 SCAPER -0.54 -13.65 -0.48 1.99e-37 Blood metabolite levels; BRCA cis rs2243480 1.000 rs160634 chr7:65528664 C/T cg18252515 chr7:66147081 NA 0.91 13.47 0.47 1.37e-36 Diabetic kidney disease; BRCA cis rs1801251 0.963 rs283481 chr2:233648091 A/G cg08000102 chr2:233561755 GIGYF2 0.61 13.21 0.46 2.16e-35 Coronary artery disease; BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg24829409 chr8:58192753 C8orf71 -0.47 -8.1 -0.31 2.77e-15 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.943 rs12709813 chr19:37844983 G/A cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg26408565 chr15:76604113 ETFA -0.48 -10.29 -0.38 4.59e-23 Blood metabolite levels; BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg10729496 chr3:10149963 C3orf24 -0.43 -8.54 -0.32 9.47e-17 Alzheimer's disease; BRCA cis rs796364 0.951 rs7586284 chr2:201068002 G/A cg23649088 chr2:200775458 C2orf69 0.61 10.58 0.39 3.19e-24 Schizophrenia; BRCA cis rs1707322 1.000 rs7531911 chr1:46330423 A/G cg03146154 chr1:46216737 IPP 0.45 9.99 0.37 6.35e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2072438 0.503 rs4837810 chr9:123881199 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.41 8.52 0.32 1.15e-16 Rheumatoid arthritis; BRCA cis rs2777491 1.000 rs7168177 chr15:41715585 A/G cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.23 -0.54 7.33e-50 Ulcerative colitis; BRCA cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.63 -0.32 4.77e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs8017423 0.647 rs12895269 chr14:90822430 T/C cg04374321 chr14:90722782 PSMC1 -0.49 -11.86 -0.42 1.75e-29 Mortality in heart failure; BRCA cis rs9467773 1.000 rs4713008 chr6:26538268 T/C cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA trans rs208520 0.690 rs1738970 chr6:66809491 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.99 -0.64 8.24e-75 Exhaled nitric oxide output; BRCA trans rs9291683 0.588 rs17247314 chr4:10004743 C/G cg26043149 chr18:55253948 FECH 0.39 8.33 0.31 5.05e-16 Bone mineral density; BRCA cis rs796364 1.000 rs281771 chr2:200812202 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.7 -12.01 -0.43 4.2000000000000004e-30 Schizophrenia; BRCA cis rs858239 0.601 rs6980224 chr7:23149137 C/T cg23682824 chr7:23144976 KLHL7 0.42 11.17 0.4 1.44e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs6570726 0.902 rs9390326 chr6:145791222 A/G cg23711669 chr6:146136114 FBXO30 -0.62 -14.03 -0.49 3.49e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs1878931 0.668 rs2074366 chr16:3439676 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.99 26.3 0.72 7.42e-104 Body mass index (adult); BRCA cis rs6964587 0.597 rs975707 chr7:91874527 C/G cg17063962 chr7:91808500 NA 0.53 12.07 0.43 2.32e-30 Breast cancer; BRCA cis rs77956314 0.515 rs7302025 chr12:117442902 C/T cg02556042 chr12:117471086 NA 0.55 10.0 0.37 5.74e-22 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg26769984 chr7:1090371 C7orf50 0.48 9.1 0.34 1.12e-18 Bronchopulmonary dysplasia; BRCA cis rs10046574 0.731 rs10270842 chr7:135163062 A/G cg27474649 chr7:135195673 CNOT4 0.52 8.06 0.3 3.88e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2439831 0.850 rs28590651 chr15:44113016 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.63 10.98 0.4 8.2e-26 Lung cancer in ever smokers; BRCA trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg22491629 chr6:157744540 C6orf35 -0.68 -12.22 -0.44 5.38e-31 Hemostatic factors and hematological phenotypes; BRCA cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg07636037 chr3:49044803 WDR6 0.52 8.53 0.32 1.04e-16 Menarche (age at onset); BRCA cis rs7824557 0.592 rs920044 chr8:11224313 C/T cg21775007 chr8:11205619 TDH 0.63 13.99 0.48 5.56e-39 Retinal vascular caliber; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg26384229 chr12:38710491 ALG10B 0.49 12.68 0.45 5.13e-33 Heart rate; BRCA cis rs7618501 0.633 rs11130234 chr3:50024758 G/T cg24110177 chr3:50126178 RBM5 -0.36 -9.71 -0.36 6.98e-21 Intelligence (multi-trait analysis); BRCA cis rs644799 1.000 rs474442 chr11:95583995 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.94 25.44 0.71 4.05e-99 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs9768139 0.708 rs921615 chr7:158117935 A/G cg24154853 chr7:158122151 PTPRN2 0.35 8.16 0.31 1.74e-15 Calcium levels; BRCA cis rs11971779 0.648 rs7799165 chr7:139084957 G/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.35e-23 Diisocyanate-induced asthma; BRCA cis rs9291683 0.645 rs11557743 chr4:10118377 C/G cg00071950 chr4:10020882 SLC2A9 -0.47 -11.28 -0.41 4.76e-27 Bone mineral density; BRCA cis rs514406 0.861 rs7417821 chr1:53295117 A/G cg27535305 chr1:53392650 SCP2 -0.32 -7.99 -0.3 6.16e-15 Monocyte count; BRCA trans rs9944715 1.000 rs9944836 chr18:43831380 C/T cg01718231 chr17:29326311 RNF135 0.45 9.09 0.34 1.21e-18 Red cell distribution width;Mean corpuscular volume; BRCA trans rs783540 1.000 rs1267657 chr15:83215251 T/C cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.0 -0.3 5.84e-15 Schizophrenia; BRCA cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.3 8.35 0.31 4.34e-16 Monocyte percentage of white cells; BRCA trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs7267979 1.000 rs6050598 chr20:25397257 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.71 0.33 2.61e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs9858542 0.953 rs3811699 chr3:49396360 T/C cg21659725 chr3:3221576 CRBN -0.45 -9.95 -0.37 8.66e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9291683 0.679 rs13137795 chr4:10051506 G/A cg11266682 chr4:10021025 SLC2A9 0.47 12.09 0.43 1.85e-30 Bone mineral density; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg19717773 chr7:2847554 GNA12 -0.38 -8.01 -0.3 5.41e-15 Height; BRCA cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg21573476 chr21:45109991 RRP1B -0.33 -8.48 -0.32 1.56e-16 Mean corpuscular volume; BRCA cis rs12474201 0.928 rs7594523 chr2:46935791 G/C cg06386533 chr2:46925753 SOCS5 0.81 18.08 0.58 2.55e-59 Height; BRCA cis rs7246657 0.722 rs2972447 chr19:38129736 C/T cg14683738 chr19:37701593 ZNF585B -0.46 -7.84 -0.3 1.96e-14 Coronary artery calcification; BRCA cis rs2153535 0.580 rs4451187 chr6:8473910 C/T cg21535247 chr6:8435926 SLC35B3 0.4 8.96 0.33 3.57e-18 Motion sickness; BRCA trans rs4332037 0.624 rs11766944 chr7:1888051 G/A cg25206134 chr2:45395956 NA 0.53 8.82 0.33 1.05e-17 Bipolar disorder; BRCA cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg25019033 chr10:957182 NA -0.43 -8.97 -0.33 3.13e-18 Eosinophil percentage of granulocytes; BRCA cis rs425277 0.606 rs262653 chr1:2090095 T/G cg24578937 chr1:2090814 PRKCZ 0.36 11.31 0.41 3.73e-27 Height; BRCA cis rs12618769 0.652 rs3754877 chr2:99184019 A/G cg10123293 chr2:99228465 UNC50 0.44 8.49 0.32 1.49e-16 Bipolar disorder; BRCA cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.32 -0.44 1.93e-31 Bipolar disorder; BRCA cis rs875971 0.545 rs73378304 chr7:65640747 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.48 9.52 0.35 3.59e-20 Aortic root size; BRCA cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.38e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg04756594 chr16:24857601 SLC5A11 0.35 8.61 0.32 5.72e-17 Intelligence (multi-trait analysis); BRCA cis rs7617773 0.817 rs6791930 chr3:48329900 A/G cg11946769 chr3:48343235 NME6 0.63 13.53 0.47 7.1e-37 Coronary artery disease; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg09877947 chr5:131593287 PDLIM4 0.38 9.78 0.36 3.94e-21 Breast cancer; BRCA cis rs8072100 0.840 rs9895746 chr17:45479099 C/A cg25173405 chr17:45401733 C17orf57 -0.56 -12.11 -0.43 1.54e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg22105103 chr4:187893119 NA 0.41 13.36 0.47 4.33e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs4845504 chr1:152960043 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.4 -0.32 2.95e-16 Inflammatory skin disease; BRCA cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg12310025 chr6:25882481 NA -0.51 -11.31 -0.41 3.65e-27 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.818 rs12498599 chr4:120468503 C/T cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA trans rs2727020 0.894 rs11040333 chr11:49346332 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -14.62 -0.5 5.59e-42 Coronary artery disease; BRCA cis rs12048904 0.541 rs6699536 chr1:101276544 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.71 18.83 0.6 3.15e-63 Multiple sclerosis; BRCA cis rs61931739 0.500 rs7306435 chr12:34482933 A/G cg06521331 chr12:34319734 NA 0.56 10.01 0.37 5.41e-22 Morning vs. evening chronotype; BRCA cis rs11025559 0.773 rs10833334 chr11:20498640 T/C cg19653624 chr11:20408972 PRMT3 -0.45 -9.88 -0.36 1.58e-21 Pursuit maintenance gain; BRCA cis rs7647973 0.554 rs13096480 chr3:49658084 A/G cg07636037 chr3:49044803 WDR6 0.5 8.23 0.31 1.02e-15 Menarche (age at onset); BRCA cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg24549020 chr5:56110836 MAP3K1 0.55 10.98 0.4 7.84e-26 Initial pursuit acceleration; BRCA cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg02551604 chr5:131831745 NA -0.39 -13.57 -0.47 4.73e-37 Asthma (sex interaction); BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg10729496 chr3:10149963 C3orf24 0.49 9.17 0.34 6.54e-19 Alzheimer's disease; BRCA trans rs7615952 0.641 rs6438951 chr3:125696999 A/G cg07211511 chr3:129823064 LOC729375 -0.61 -10.87 -0.4 2.29e-25 Blood pressure (smoking interaction); BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg19346786 chr7:2764209 NA -0.31 -8.98 -0.33 3.11e-18 Height; BRCA cis rs9388451 0.626 rs3799708 chr6:126078530 C/T cg05901451 chr6:126070800 HEY2 -0.55 -14.89 -0.51 2.88e-43 Brugada syndrome; BRCA cis rs875971 0.545 rs10950029 chr7:65634321 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.2 0.37 9.45e-23 Aortic root size; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg13397359 chr6:42928475 GNMT 0.66 16.08 0.54 4.1e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs589448 0.902 rs642786 chr12:69758462 T/C cg20891283 chr12:69753455 YEATS4 0.84 28.33 0.75 5.71e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs7799006 0.929 rs6951493 chr7:2257612 G/A cg08027265 chr7:2291960 NA -0.4 -10.04 -0.37 4.17e-22 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs4363385 0.747 rs1577964 chr1:152961784 C/A cg24667326 chr1:152973720 SPRR3 -0.33 -8.98 -0.33 3.06e-18 Inflammatory skin disease; BRCA cis rs724568 0.565 rs13405830 chr2:67952260 A/G cg14046302 chr2:67939758 NA -0.37 -9.81 -0.36 3.07e-21 Major depressive disorder (broad); BRCA cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg21770322 chr7:97807741 LMTK2 0.44 11.54 0.42 4.02e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs992157 0.835 rs6729058 chr2:219148369 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.23 -0.41 7.51e-27 Colorectal cancer; BRCA trans rs11764590 0.671 rs62444906 chr7:2083161 G/T cg25206134 chr2:45395956 NA 0.53 8.37 0.31 3.66e-16 Neuroticism; BRCA cis rs919433 0.680 rs787983 chr2:198345797 C/T cg00792783 chr2:198669748 PLCL1 0.35 8.11 0.31 2.56e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs13102973 0.640 rs4608865 chr4:135885434 G/A cg14419869 chr4:135874104 NA -0.5 -9.84 -0.36 2.33e-21 Subjective well-being; BRCA cis rs7254827 0.737 rs34563036 chr19:17154195 C/T cg19418318 chr19:17219073 MYO9B -0.48 -10.13 -0.37 1.86e-22 Mean platelet volume; BRCA cis rs11105298 0.891 rs10858871 chr12:89871613 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.6 -9.95 -0.37 8.92e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6088590 0.561 rs764597 chr20:33161225 C/T cg08999081 chr20:33150536 PIGU 0.49 13.7 0.48 1.19e-37 Coronary artery disease; BRCA cis rs2797160 0.967 rs1343120 chr6:125992810 A/G cg05901451 chr6:126070800 HEY2 -0.41 -10.14 -0.37 1.63e-22 Endometrial cancer; BRCA cis rs754466 0.561 rs11002343 chr10:79705871 G/A cg17075019 chr10:79541650 NA -0.54 -7.98 -0.3 6.56e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6690583 1.000 rs10443172 chr1:85485768 T/C cg22153463 chr1:85462885 MCOLN2 -0.57 -9.99 -0.37 5.94e-22 Serum sulfate level; BRCA trans rs2197308 0.765 rs12230545 chr12:37927114 C/T cg06521331 chr12:34319734 NA 0.43 8.41 0.32 2.77e-16 Morning vs. evening chronotype; BRCA cis rs9443645 0.901 rs9343844 chr6:79586463 T/A cg18132916 chr6:79620363 NA -0.48 -10.89 -0.4 1.89e-25 Intelligence (multi-trait analysis); BRCA cis rs7949030 1.000 rs10897289 chr11:62400016 T/C cg22862634 chr11:62369728 EML3;MTA2 0.43 10.44 0.38 1.14e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7615952 0.611 rs9681518 chr3:125615130 A/G cg05084668 chr3:125655381 ALG1L -0.82 -11.53 -0.41 4.52e-28 Blood pressure (smoking interaction); BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg09877947 chr5:131593287 PDLIM4 0.49 12.48 0.44 3.8e-32 Acylcarnitine levels; BRCA cis rs2625529 0.761 rs3743224 chr15:72466799 C/T cg16672083 chr15:72433130 SENP8 -0.83 -17.56 -0.57 1.25e-56 Red blood cell count; BRCA cis rs11051970 0.879 rs2733682 chr12:32574608 G/A cg24626660 chr12:32551988 NA 0.29 8.15 0.31 1.91e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg13047869 chr3:10149882 C3orf24 0.6 12.65 0.45 6.87e-33 Alzheimer's disease; BRCA cis rs4319547 0.656 rs10734918 chr12:122921512 A/C cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.71 -0.36 7.16e-21 Body mass index; BRCA cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 8.91e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg07148914 chr20:33460835 GGT7 -0.42 -9.03 -0.34 1.99e-18 Height; BRCA cis rs2836974 0.644 rs4818017 chr21:40690561 G/T cg11644478 chr21:40555479 PSMG1 -0.67 -14.44 -0.5 4.36e-41 Cognitive function; BRCA cis rs9527 0.545 rs10218853 chr10:104796787 A/C cg04362960 chr10:104952993 NT5C2 0.42 9.74 0.36 5.38e-21 Arsenic metabolism; BRCA cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg04727924 chr7:799746 HEATR2 -0.55 -10.87 -0.4 2.25e-25 Cerebrospinal P-tau181p levels; BRCA cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg03213289 chr20:61660250 NA 0.62 16.39 0.54 1.23e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg18357645 chr12:58087776 OS9 0.33 8.06 0.3 3.89e-15 Multiple sclerosis; BRCA cis rs68092024 0.731 rs792841 chr3:99471308 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.67 -0.39 1.43e-24 Cleft lip with or without cleft palate; BRCA cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg13256891 chr4:100009986 ADH5 0.51 10.53 0.38 5.08e-24 Alcohol dependence; BRCA cis rs7582180 0.764 rs7425449 chr2:100928393 A/G cg14675211 chr2:100938903 LONRF2 0.5 11.42 0.41 1.35e-27 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.568 rs8130795 chr21:40549983 T/A cg06238570 chr21:40685208 BRWD1 0.44 8.91 0.33 5.37e-18 Cognitive function; BRCA cis rs13064411 0.696 rs2399479 chr3:113227050 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -11.79 -0.42 3.58e-29 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.21 -0.34 4.57e-19 Alzheimer's disease (late onset); BRCA cis rs2652822 1.000 rs1126308 chr15:63429086 G/T cg02713581 chr15:63449717 RPS27L -0.46 -9.5 -0.35 4.11e-20 Metabolic traits; BRCA cis rs765787 0.530 rs11070445 chr15:45513163 T/A cg24006582 chr15:45444508 DUOX1 0.56 11.26 0.41 6.01e-27 Uric acid levels; BRCA cis rs1865721 1.000 rs11659761 chr18:73186974 A/G cg26385618 chr18:73139727 C18orf62 -0.39 -8.85 -0.33 8.71e-18 Intelligence; BRCA cis rs7677751 0.806 rs60806423 chr4:55086816 C/T cg17187183 chr4:55093834 PDGFRA 0.45 8.95 0.33 3.96e-18 Corneal astigmatism; BRCA cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg07952391 chr2:88470173 THNSL2 0.58 8.09 0.3 3.09e-15 Plasma clusterin levels; BRCA cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg16179182 chr5:140090404 VTRNA1-1 0.46 10.87 0.4 2.26e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs6450176 1.000 rs7735253 chr5:53297611 G/A ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.18 -0.51 1.2e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 8.23 0.31 1.04e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.45 0.35 6.39e-20 Motion sickness; BRCA cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.79 0.42 3.68e-29 Homoarginine levels; BRCA cis rs4820539 1.000 rs885964 chr22:23461003 G/C cg14186256 chr22:23484241 RTDR1 0.77 23.32 0.68 1.77e-87 Bone mineral density; BRCA trans rs1493916 0.837 rs4992177 chr18:31407020 C/T cg15819921 chr19:927150 ARID3A -0.41 -8.07 -0.3 3.37e-15 Life satisfaction; BRCA cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg18876405 chr7:65276391 NA 0.62 15.47 0.52 4.15e-46 Aortic root size; BRCA cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg00071950 chr4:10020882 SLC2A9 -0.43 -10.11 -0.37 2.14e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12200560 0.505 rs211162 chr6:97067344 G/A cg06623918 chr6:96969491 KIAA0776 0.51 12.09 0.43 1.99e-30 Coronary heart disease; BRCA cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg11789530 chr4:8429930 ACOX3 0.66 16.29 0.54 3.73e-50 Response to antineoplastic agents; BRCA trans rs10411161 0.702 rs7251755 chr19:52388948 G/A cg22319618 chr22:45562946 NUP50 -0.42 -8.02 -0.3 4.89e-15 Breast cancer; BRCA cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg01483505 chr11:975446 AP2A2 0.32 8.43 0.32 2.36e-16 Alzheimer's disease (late onset); BRCA cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg24812749 chr6:127587940 RNF146 0.65 14.65 0.5 4.28e-42 Breast cancer; BRCA cis rs67478160 0.643 rs2295141 chr14:104212949 T/C cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.17 -0.4 1.33e-26 Schizophrenia; BRCA cis rs10504229 1.000 rs77120900 chr8:58170368 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.23e-36 Developmental language disorder (linguistic errors); BRCA cis rs11190604 0.943 rs7900678 chr10:102229016 T/C cg07080220 chr10:102295463 HIF1AN 0.49 11.31 0.41 3.76e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10465746 0.780 rs2389649 chr1:84379449 C/T cg10977910 chr1:84465055 TTLL7 0.55 11.51 0.41 5.39e-28 Obesity-related traits; BRCA cis rs9287719 0.934 rs10181806 chr2:10741141 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.81e-15 Prostate cancer; BRCA cis rs12541635 0.677 rs1006480 chr8:106975524 T/C cg10147462 chr8:107024639 NA 0.39 10.48 0.38 7.74e-24 Age of smoking initiation; BRCA cis rs11231017 0.507 rs9633987 chr11:62071249 C/T cg23876832 chr11:62092739 NA 0.32 8.09 0.3 2.91e-15 HIV-1 viral setpoint; BRCA cis rs3772130 1.000 rs11714406 chr3:121372513 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.33 0.35 1.74e-19 Cognitive performance; BRCA cis rs2836974 0.583 rs2776306 chr21:40713754 A/G cg17971929 chr21:40555470 PSMG1 0.51 11.61 0.42 2.02e-28 Cognitive function; BRCA cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg02475777 chr4:1388615 CRIPAK -0.51 -9.87 -0.36 1.73e-21 Obesity-related traits; BRCA trans rs6598955 0.671 rs41285347 chr1:26644399 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.22 -0.52 7.28e-45 Obesity-related traits; BRCA cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg18867708 chr6:26865862 GUSBL1 0.42 8.26 0.31 8.26e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs312274 0.569 rs4638361 chr12:41319355 A/G cg17827154 chr12:41323612 CNTN1 -0.42 -10.47 -0.38 8.73e-24 Metabolite levels (X-11787); BRCA cis rs908922 0.582 rs1856121 chr1:152512169 A/T cg20991723 chr1:152506922 NA 0.39 9.08 0.34 1.36e-18 Hair morphology; BRCA cis rs7809950 0.817 rs2253833 chr7:107205669 A/G cg23024343 chr7:107201750 COG5 0.48 9.93 0.37 1.06e-21 Coronary artery disease; BRCA cis rs2629540 0.847 rs10901811 chr10:126417914 G/A cg08799069 chr10:126477246 METTL10 0.44 9.04 0.34 1.91e-18 Cocaine dependence; BRCA cis rs9858213 1 rs9858213 chr3:49731861 G/T cg03060546 chr3:49711283 APEH -0.57 -11.1 -0.4 2.76e-26 Educational attainment; BRCA cis rs7618915 0.621 rs6788993 chr3:52605136 T/C cg10802521 chr3:52805072 NEK4 -0.33 -8.9 -0.33 5.54e-18 Bipolar disorder; BRCA cis rs789294 1 rs789294 chr3:154057741 C/G cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs826838 0.935 rs11183940 chr12:38851642 A/G cg26384229 chr12:38710491 ALG10B 0.85 22.52 0.67 3.94e-83 Heart rate; BRCA cis rs2762353 0.779 rs1408273 chr6:25840946 C/T cg12310025 chr6:25882481 NA 0.43 10.8 0.39 4.17e-25 Blood metabolite levels; BRCA cis rs17401966 1.000 rs11121533 chr1:10292888 G/C cg03954927 chr1:10346856 KIF1B 0.44 13.05 0.46 1.08e-34 Hepatocellular carcinoma; BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg14789911 chr21:47582049 C21orf56 -0.38 -7.99 -0.3 6.29e-15 Testicular germ cell tumor; BRCA cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.5 0.44 3.09e-32 Electroencephalogram traits; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg21782813 chr7:2030301 MAD1L1 -0.36 -9.73 -0.36 5.88e-21 Bipolar disorder and schizophrenia; BRCA cis rs11971779 0.941 rs7800795 chr7:139080348 A/G cg07862535 chr7:139043722 LUC7L2 0.53 12.87 0.45 7.08e-34 Diisocyanate-induced asthma; BRCA cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg26384229 chr12:38710491 ALG10B 0.67 15.18 0.51 1.13e-44 Bladder cancer; BRCA cis rs9560113 1.000 rs11620313 chr13:112179363 G/A cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs10911251 0.528 rs10911248 chr1:183080564 G/A ch.1.3577855R chr1:183094577 LAMC1 0.68 18.04 0.58 4.21e-59 Colorectal cancer; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18402987 chr7:1209562 NA 0.65 14.81 0.51 6.9e-43 Longevity;Endometriosis; BRCA cis rs2749592 0.531 rs10764134 chr10:37856660 T/C cg25427524 chr10:38739819 LOC399744 0.58 13.06 0.46 1.01e-34 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12474201 0.928 rs17822019 chr2:46934505 T/C cg06386533 chr2:46925753 SOCS5 0.87 18.92 0.6 1.02e-63 Height; BRCA cis rs1577917 1.000 rs34852683 chr6:86702330 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.04 -0.43 3.09e-30 Response to antipsychotic treatment; BRCA cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 17.19 0.56 1.06e-54 Hip circumference adjusted for BMI; BRCA cis rs9443645 0.901 rs9352683 chr6:79718795 T/G cg11833968 chr6:79620685 NA -0.43 -9.55 -0.35 2.75e-20 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.686 rs9376961 chr6:146048737 C/T cg23711669 chr6:146136114 FBXO30 0.66 14.94 0.51 1.6700000000000001e-43 Lobe attachment (rater-scored or self-reported); BRCA trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg15704280 chr7:45808275 SEPT13 0.6 10.71 0.39 9.62e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs7777754 0.512 rs7785224 chr7:50562361 T/C cg18232548 chr7:50535776 DDC -0.51 -12.79 -0.45 1.57e-33 Response to zileuton treatment in asthma (FEV1 change interaction); BRCA cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg10578991 chr7:12443926 VWDE -0.57 -8.08 -0.3 3.31e-15 Coronary artery disease; BRCA cis rs6426558 0.502 rs10916080 chr1:227232040 A/G cg10327440 chr1:227177885 CDC42BPA 0.48 9.49 0.35 4.49e-20 Neutrophil percentage of white cells; BRCA cis rs367943 0.965 rs644154 chr5:112799080 G/T cg12552261 chr5:112820674 MCC -0.55 -12.1 -0.43 1.81e-30 Type 2 diabetes; BRCA cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg27347728 chr4:17578864 LAP3 0.44 8.54 0.32 1.01e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12618769 0.597 rs72821943 chr2:99141640 T/C cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA trans rs6582630 0.513 rs1596446 chr12:38282160 C/T cg06521331 chr12:34319734 NA 0.5 9.63 0.36 1.34e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg08085267 chr17:45401833 C17orf57 0.66 14.35 0.49 1.11e-40 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.44 -8.88 -0.33 6.8e-18 Tonsillectomy; BRCA cis rs60843830 1.000 rs7605824 chr2:280819 A/G cg00108164 chr2:264199 ACP1;SH3YL1 -0.73 -14.83 -0.51 5.57e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.22 -0.54 8.78e-50 Alzheimer's disease (late onset); BRCA cis rs1400816 0.702 rs58565148 chr2:172535396 C/T cg13550731 chr2:172543902 DYNC1I2 0.54 8.48 0.32 1.56e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs7829975 0.509 rs7838674 chr8:8797073 A/T cg08975724 chr8:8085496 FLJ10661 -0.42 -8.81 -0.33 1.2e-17 Mood instability; BRCA trans rs7786808 0.649 rs6459879 chr7:158211792 C/G cg02030672 chr11:45687055 CHST1 0.38 8.67 0.32 3.64e-17 Obesity-related traits; BRCA cis rs7649275 0.882 rs755886 chr3:53791948 A/T cg21503701 chr3:53781065 CACNA1D 0.45 8.06 0.3 3.86e-15 Trans fatty acid levels; BRCA cis rs2836974 0.590 rs9974757 chr21:40617244 T/C cg06238570 chr21:40685208 BRWD1 -0.41 -8.32 -0.31 5.38e-16 Cognitive function; BRCA cis rs524281 0.817 rs7115081 chr11:65853541 A/G cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4.15e-15 Electroencephalogram traits; BRCA cis rs7481584 0.624 rs516443 chr11:3047294 A/G cg08508325 chr11:3079039 CARS 0.28 8.49 0.32 1.5e-16 Calcium levels; BRCA cis rs9815354 0.812 rs4299460 chr3:41952445 A/C cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs736408 0.812 rs2071507 chr3:52826707 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.31 8.97 0.33 3.33e-18 Bipolar disorder; BRCA cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -9.84 -0.36 2.23e-21 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg11644478 chr21:40555479 PSMG1 -0.68 -14.83 -0.51 5.69e-43 Cognitive function; BRCA cis rs66887589 0.616 rs10032299 chr4:120206419 C/T cg09307838 chr4:120376055 NA 0.44 9.15 0.34 7.81e-19 Diastolic blood pressure; BRCA cis rs10463316 0.817 rs11167545 chr5:150778076 C/T cg03212797 chr5:150827313 SLC36A1 -0.4 -7.89 -0.3 1.3e-14 Metabolite levels (Pyroglutamine); BRCA cis rs6087990 0.899 rs6058893 chr20:31392777 C/T cg13636640 chr20:31349939 DNMT3B 0.68 21.15 0.64 1.08e-75 Ulcerative colitis; BRCA cis rs7666738 0.753 rs2903143 chr4:99040480 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.62 0.55 8.44e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.73 0.42 6.59e-29 Tonsillectomy; BRCA cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg12463550 chr7:65579703 CRCP -0.37 -8.02 -0.3 5.18e-15 Aortic root size; BRCA cis rs7805747 1.000 rs10480299 chr7:151405818 A/G cg17611936 chr7:151411526 PRKAG2 0.4 7.87 0.3 1.55e-14 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg22903471 chr2:27725779 GCKR -0.36 -8.73 -0.33 2.29e-17 Total body bone mineral density; BRCA trans rs8062405 0.895 rs56186137 chr16:28825953 A/G cg09719594 chr16:21412588 NA -0.32 -8.0 -0.3 6.07e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs2204008 0.805 rs11169513 chr12:37988640 G/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.79e-21 Bladder cancer; BRCA cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.21 -0.31 1.26e-15 Menarche (age at onset); BRCA cis rs67460515 0.563 rs68166680 chr3:160829735 T/A cg03342759 chr3:160939853 NMD3 -0.72 -14.78 -0.5 1.01e-42 Parkinson's disease; BRCA cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.57 12.55 0.44 1.93e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg13880726 chr7:1868755 MAD1L1 0.43 8.49 0.32 1.47e-16 Bipolar disorder and schizophrenia; BRCA cis rs208520 0.690 rs12194057 chr6:66745616 A/G cg07460842 chr6:66804631 NA 0.99 19.82 0.62 1.59e-68 Exhaled nitric oxide output; BRCA cis rs7772486 0.764 rs2265468 chr6:146218346 A/C cg23711669 chr6:146136114 FBXO30 0.79 18.22 0.58 4.92e-60 Lobe attachment (rater-scored or self-reported); BRCA cis rs3784262 0.669 rs17820990 chr15:58349568 C/T cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.57 -0.39 3.69e-24 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6582630 0.554 rs8189625 chr12:38401177 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.88 -0.36 1.65e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg02475777 chr4:1388615 CRIPAK 0.38 8.33 0.31 5.12e-16 Longevity; BRCA cis rs2075371 0.933 rs431306 chr7:133955974 A/T cg11752832 chr7:134001865 SLC35B4 0.5 12.69 0.45 4.42e-33 Mean platelet volume; BRCA cis rs12762955 0.561 rs7918118 chr10:1042823 C/A cg20503657 chr10:835505 NA -0.54 -9.89 -0.36 1.42e-21 Response to angiotensin II receptor blocker therapy; BRCA cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg11764359 chr7:65958608 NA 0.66 12.01 0.43 4.34e-30 Aortic root size; BRCA cis rs7809950 0.678 rs17153981 chr7:106922106 A/G cg23024343 chr7:107201750 COG5 -0.46 -9.15 -0.34 7.64e-19 Coronary artery disease; BRCA cis rs1403694 0.695 rs5029970 chr3:186434491 T/C cg12454167 chr3:186435060 KNG1 0.29 7.94 0.3 8.96e-15 Blood protein levels; BRCA cis rs11148252 0.846 rs1056335 chr13:52989863 C/T cg00495681 chr13:53174319 NA 0.41 8.66 0.32 3.93e-17 Lewy body disease; BRCA cis rs752010 0.871 rs10789405 chr1:42101962 C/T cg06885757 chr1:42089581 HIVEP3 0.25 8.92 0.33 4.78e-18 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg24372256 chr21:43528868 UMODL1;C21orf128 -0.44 -9.03 -0.34 2.06e-18 IgG glycosylation; BRCA cis rs311392 1.000 rs311392 chr8:55084782 A/G cg20636351 chr8:55087400 NA -0.29 -7.95 -0.3 8.33e-15 Pelvic organ prolapse (moderate/severe); BRCA cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg21770322 chr7:97807741 LMTK2 0.44 11.77 0.42 4.58e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6733011 0.519 rs12990579 chr2:99457447 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -7.81 -0.3 2.29e-14 Bipolar disorder; BRCA cis rs757110 0.866 rs5213 chr11:17408404 C/T cg15432903 chr11:17409602 KCNJ11 0.79 17.2 0.56 9.29e-55 Type 2 diabetes; BRCA cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7975161 0.630 rs4129598 chr12:104620638 T/C cg25273343 chr12:104657179 TXNRD1 -0.61 -10.34 -0.38 2.74e-23 Toenail selenium levels; BRCA cis rs208520 0.690 rs866452 chr6:66849936 A/T cg07460842 chr6:66804631 NA -1.0 -20.23 -0.62 1.01e-70 Exhaled nitric oxide output; BRCA cis rs67460515 0.563 rs1599388 chr3:160846866 A/G cg03342759 chr3:160939853 NMD3 -0.72 -14.82 -0.51 6.35e-43 Parkinson's disease; BRCA cis rs965469 1.000 rs6051708 chr20:3262493 A/G cg25506879 chr20:3388711 C20orf194 -0.48 -9.03 -0.34 2.04e-18 IFN-related cytopenia; BRCA cis rs7824557 0.707 rs3808518 chr8:11143272 A/C cg21775007 chr8:11205619 TDH -0.6 -12.42 -0.44 7.3e-32 Retinal vascular caliber; BRCA cis rs72634258 0.503 rs34177663 chr1:7833228 A/G cg26816564 chr1:7831052 VAMP3 0.73 12.95 0.46 3.1e-34 Inflammatory bowel disease; BRCA cis rs7178424 1.000 rs7178945 chr15:62379814 T/C cg00456672 chr15:62358751 C2CD4A -0.34 -8.15 -0.31 1.87e-15 Height; BRCA cis rs826838 1.000 rs1684416 chr12:39130301 G/A cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg26116260 chr4:7069785 GRPEL1 -0.95 -26.48 -0.72 7.5e-105 Monocyte percentage of white cells; BRCA cis rs6964587 1.000 rs6952389 chr7:91657994 A/G cg17063962 chr7:91808500 NA 0.53 12.58 0.45 1.43e-32 Breast cancer; BRCA cis rs12986413 1.000 rs11882273 chr19:2173836 T/C cg09261902 chr19:2140048 AP3D1 0.38 9.94 0.37 9.61e-22 Height; BRCA trans rs11088226 0.681 rs74779447 chr21:33929013 G/A cg09050820 chr6:167586206 TCP10L2 0.79 13.98 0.48 6.21e-39 Gastritis; BRCA cis rs6748734 0.779 rs4401206 chr2:241796905 A/G cg04034577 chr2:241836375 C2orf54 -0.5 -12.59 -0.45 1.21e-32 Urinary metabolites; BRCA cis rs4589502 1.000 rs79390908 chr15:67130924 C/T cg09911534 chr15:67153556 NA -0.81 -10.09 -0.37 2.57e-22 Lung cancer (smoking interaction); BRCA cis rs2204008 0.627 rs11176531 chr12:38152166 T/G cg26384229 chr12:38710491 ALG10B 0.72 15.5 0.52 2.97e-46 Bladder cancer; BRCA trans rs17685 0.753 rs4728550 chr7:75670988 C/A cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.72 -0.74 1.21e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7246657 0.722 rs2909100 chr19:38212680 C/T cg18154014 chr19:37997991 ZNF793 -0.49 -9.39 -0.35 1.03e-19 Coronary artery calcification; BRCA cis rs9837602 0.529 rs793458 chr3:99520169 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.4 -0.52 1.02e-45 Breast cancer; BRCA cis rs9815354 0.812 rs59138513 chr3:41908611 T/G cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs804292 1.000 rs804292 chr8:11643915 C/T cg26752888 chr8:11627280 NEIL2 -0.76 -15.74 -0.53 2.08e-47 Alcohol dependence;Nicotine use; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.41 9.18 0.34 5.89e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9329289 0.510 rs12359941 chr10:2547015 G/A cg15501526 chr10:2543763 NA 0.46 10.7 0.39 1.06e-24 Age-related hearing impairment; BRCA cis rs2070488 1.000 rs2268758 chr3:38514049 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.74 20.65 0.63 5.7e-73 Electrocardiographic conduction measures; BRCA cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg14829155 chr15:31115871 NA -0.42 -10.21 -0.37 9.21e-23 Huntington's disease progression; BRCA trans rs3857536 0.813 rs6903411 chr6:66938288 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs9337951 0.595 rs2478835 chr10:30317949 C/T cg00730780 chr10:30316187 KIAA1462 -0.47 -9.79 -0.36 3.63e-21 Pulse pressure;Coronary artery disease; BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg10802521 chr3:52805072 NEK4 -0.29 -7.96 -0.3 7.6e-15 Bipolar disorder; BRCA cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.773 rs17757926 chr7:91987702 T/C cg01689657 chr7:91764605 CYP51A1 0.23 7.96 0.3 8e-15 Breast cancer; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg08888203 chr3:10149979 C3orf24 0.65 11.96 0.43 6.52e-30 Alzheimer's disease; BRCA cis rs7772486 0.875 rs12194437 chr6:146411440 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.8 -0.33 1.3e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs3862030 0.810 rs11593710 chr10:104328719 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.47 -14.01 -0.48 4.34e-39 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs17376456 0.877 rs10476526 chr5:93461916 G/A cg25358565 chr5:93447407 FAM172A 1.2 19.89 0.62 7.04e-69 Diabetic retinopathy; BRCA cis rs17092148 1.000 rs7271289 chr20:33397303 C/T cg16810054 chr20:33298113 TP53INP2 0.49 11.17 0.4 1.35e-26 Neuroticism; BRCA cis rs977987 0.806 rs17696696 chr16:75393352 G/T cg03315344 chr16:75512273 CHST6 -0.52 -12.41 -0.44 7.93e-32 Dupuytren's disease; BRCA cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs826838 0.967 rs11183022 chr12:38652519 G/A cg13010199 chr12:38710504 ALG10B 0.57 12.57 0.45 1.55e-32 Heart rate; BRCA cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 3.95e-25 Bipolar disorder; BRCA cis rs34421088 0.548 rs2618443 chr8:11384556 A/G cg21775007 chr8:11205619 TDH -0.38 -7.95 -0.3 8.72e-15 Neuroticism; BRCA cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg13010199 chr12:38710504 ALG10B 0.42 8.65 0.32 4.32e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg21573476 chr21:45109991 RRP1B -0.36 -9.25 -0.34 3.21e-19 Mean corpuscular volume; BRCA cis rs41005 1.000 rs798450 chr2:8107093 C/T cg03155496 chr2:8117019 LOC339788 0.56 14.89 0.51 3.02e-43 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg20701182 chr2:24300061 SF3B14 0.68 9.83 0.36 2.55e-21 Lymphocyte counts; BRCA cis rs870825 0.550 rs57301026 chr4:185646505 C/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.38 -8.53 -0.32 1.07e-16 Longevity;Endometriosis; BRCA cis rs9393777 0.623 rs3757150 chr6:26476782 T/A cg12826209 chr6:26865740 GUSBL1 0.56 9.23 0.34 3.92e-19 Intelligence (multi-trait analysis); BRCA cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg06697600 chr4:7070879 GRPEL1 -0.55 -11.27 -0.41 5.42e-27 Monocyte percentage of white cells; BRCA cis rs1153858 1.000 rs16942000 chr15:45633003 C/T cg14582100 chr15:45693742 SPATA5L1 0.37 12.16 0.43 9.5e-31 Homoarginine levels; BRCA cis rs2180341 1.000 rs3798853 chr6:127636823 C/T cg27446573 chr6:127587934 RNF146 -0.93 -21.58 -0.65 5.23e-78 Breast cancer; BRCA cis rs6842047 1.000 rs9995366 chr4:187131384 T/C cg09526685 chr4:187126073 CYP4V2 0.73 9.93 0.37 1.03e-21 Blood protein levels; BRCA cis rs1165205 0.558 rs793144 chr6:25879321 C/T cg12310025 chr6:25882481 NA -0.81 -21.07 -0.64 3.01e-75 Urate levels; BRCA cis rs3733585 0.699 rs28613263 chr4:9964880 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2422052 0.614 rs13033724 chr2:118644670 C/T cg22545206 chr2:118617499 NA 0.38 9.25 0.34 3.2e-19 Mosquito bite size; BRCA cis rs751728 0.664 rs2296744 chr6:33740382 G/A cg25922239 chr6:33757077 LEMD2 0.49 11.93 0.43 8.9e-30 Crohn's disease; BRCA cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg13854012 chr2:162103682 NA -0.39 -8.69 -0.33 2.94e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs7098414 0.511 rs10466236 chr10:82149717 C/T cg00277334 chr10:82204260 NA 0.52 11.16 0.4 1.52e-26 Post bronchodilator FEV1; BRCA cis rs1707322 1.000 rs4298677 chr1:46306619 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.83 0.39 3.23e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg00814883 chr7:100076585 TSC22D4 -0.54 -10.51 -0.38 6.04e-24 Platelet count; BRCA cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg08859206 chr1:53392774 SCP2 0.45 10.04 0.37 4.12e-22 Monocyte count; BRCA cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg22800045 chr5:56110881 MAP3K1 0.51 9.9 0.36 1.36e-21 Type 2 diabetes; BRCA cis rs7178424 0.742 rs1981917 chr15:62171906 A/G cg00456672 chr15:62358751 C2CD4A -0.37 -8.9 -0.33 5.84e-18 Height; BRCA cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg10523679 chr1:76189770 ACADM 0.76 15.9 0.53 3.47e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9790314 0.535 rs4679922 chr3:160642984 T/C cg03342759 chr3:160939853 NMD3 0.43 8.31 0.31 5.73e-16 Morning vs. evening chronotype; BRCA cis rs9296092 0.500 rs9461885 chr6:33521069 G/T cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA trans rs9325144 0.555 rs4882279 chr12:38688918 C/A cg23762105 chr12:34175262 ALG10 -0.36 -9.01 -0.34 2.34e-18 Morning vs. evening chronotype; BRCA cis rs1198430 1.000 rs1198434 chr1:23758134 A/G cg19827787 chr1:23763612 ASAP3 0.35 9.24 0.34 3.5e-19 Total cholesterol levels; BRCA trans rs9397585 0.599 rs685826 chr6:153411255 C/T cg25263898 chr1:36774223 C1orf113 -0.45 -8.56 -0.32 8.48e-17 Body mass index; BRCA cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg18225595 chr11:63971243 STIP1 0.43 10.93 0.4 1.34e-25 Platelet count; BRCA cis rs7552167 0.925 rs7546025 chr1:24510252 T/C cg01960748 chr1:24522592 NA -0.61 -10.03 -0.37 4.54e-22 Psoriasis vulgaris; BRCA cis rs7254827 0.868 rs62127865 chr19:17210164 A/G cg19418318 chr19:17219073 MYO9B -0.51 -10.4 -0.38 1.69e-23 Mean platelet volume; BRCA cis rs7267979 1.000 rs2257420 chr20:25275890 C/A cg08601574 chr20:25228251 PYGB 0.35 8.48 0.32 1.51e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs11098499 0.863 rs2306456 chr4:120472422 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs6913100 chr6:8456855 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.81 0.33 1.19e-17 Motion sickness; BRCA cis rs36052053 0.908 rs34780834 chr6:109624766 C/A cg12927641 chr6:109611667 NA -0.5 -7.84 -0.3 1.95e-14 Red cell distribution width; BRCA cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.34e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3809566 1.000 rs4774471 chr15:63332645 A/T cg12160578 chr15:63334699 TPM1 0.43 8.9 0.33 5.53e-18 Platelet count; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg18301423 chr5:131593218 PDLIM4 0.33 7.85 0.3 1.79e-14 Acylcarnitine levels; BRCA cis rs477692 0.673 rs579952 chr10:131356084 A/T cg05714579 chr10:131428358 MGMT -0.5 -11.02 -0.4 5.4e-26 Response to temozolomide; BRCA cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.84 0.36 2.3e-21 Bipolar disorder; BRCA cis rs4147929 0.532 rs757232 chr19:1075979 C/T cg12082025 chr19:1064218 ABCA7 0.4 7.83 0.3 1.98e-14 Alzheimer's disease (late onset); BRCA cis rs9487051 0.872 rs9386790 chr6:109608460 G/T cg21918786 chr6:109611834 NA 0.5 14.56 0.5 1.1e-41 Reticulocyte fraction of red cells; BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg04944784 chr2:26401820 FAM59B -0.68 -11.27 -0.41 5.52e-27 Gut microbiome composition (summer); BRCA cis rs4148883 0.645 rs1154404 chr4:100009004 A/T cg12011299 chr4:100065546 ADH4 0.42 10.92 0.4 1.5e-25 Alcohol dependence; BRCA cis rs4862750 0.832 rs6836076 chr4:187899660 A/C cg11301795 chr4:187892539 NA -0.27 -8.71 -0.33 2.5e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 0.843 rs2860494 chr19:19470426 T/C cg15839431 chr19:19639596 YJEFN3 0.36 8.21 0.31 1.19e-15 Bipolar disorder; BRCA cis rs2882667 0.690 rs288024 chr5:138223792 A/G cg04439458 chr5:138467593 SIL1 -0.34 -8.36 -0.31 4.08e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs8114671 0.805 rs4616 chr20:33590358 C/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.44 -0.32 2.2e-16 Height; BRCA cis rs35146811 0.735 rs1727133 chr7:99812870 C/T cg13334819 chr7:99746414 C7orf59 0.34 8.05 0.3 4.16e-15 Coronary artery disease; BRCA cis rs72781680 0.898 rs55761273 chr2:23957849 A/G cg20701182 chr2:24300061 SF3B14 0.56 8.63 0.32 4.99e-17 Lymphocyte counts; BRCA cis rs7786808 0.776 rs11983316 chr7:158209742 A/G cg01191920 chr7:158217561 PTPRN2 -0.37 -8.63 -0.32 4.91e-17 Obesity-related traits; BRCA cis rs7833790 0.963 rs72686466 chr8:82758928 G/T cg27398817 chr8:82754497 SNX16 0.49 9.26 0.34 2.97e-19 Diastolic blood pressure; BRCA cis rs1005224 0.819 rs10147492 chr14:76155309 T/G cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.23 -0.31 1.01e-15 Large artery stroke; BRCA cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg05340658 chr4:99064831 C4orf37 0.67 16.59 0.55 1.2e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs1113500 0.933 rs1414674 chr1:108625947 A/G cg06207961 chr1:108661230 NA 0.46 11.24 0.41 6.97e-27 Growth-regulated protein alpha levels; BRCA cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg13298116 chr11:62369859 EML3;MTA2 0.58 13.6 0.47 3.39e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg02564969 chr6:151773285 C6orf211;RMND1 0.41 9.8 0.36 3.31e-21 Menarche (age at onset); BRCA cis rs7927771 0.524 rs1563821 chr11:47756568 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.57 0.35 2.28e-20 Subjective well-being; BRCA trans rs853679 0.607 rs13190888 chr6:28285985 G/A cg01620082 chr3:125678407 NA -0.84 -9.88 -0.36 1.61e-21 Depression; BRCA cis rs4594175 0.926 rs4349056 chr14:51625819 A/G cg23942311 chr14:51606299 NA 0.33 8.26 0.31 8.09e-16 Cancer; BRCA cis rs4302748 0.818 rs61387197 chr7:36184016 T/A cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9388451 0.537 rs1739383 chr6:126098915 G/T cg05901451 chr6:126070800 HEY2 -0.54 -14.14 -0.49 1.1e-39 Brugada syndrome; BRCA cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg12386194 chr3:101231763 SENP7 0.39 8.37 0.31 3.7e-16 Colorectal cancer; BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg02951883 chr7:2050386 MAD1L1 0.49 10.78 0.39 5.25e-25 Bipolar disorder and schizophrenia; BRCA cis rs9649465 1.000 rs13230294 chr7:123380821 T/C cg04330084 chr7:123175371 IQUB -0.32 -8.81 -0.33 1.17e-17 Migraine; BRCA cis rs6545883 0.894 rs2694632 chr2:61558682 T/C cg15711740 chr2:61764176 XPO1 0.52 13.42 0.47 2.33e-36 Tuberculosis; BRCA trans rs2739330 0.760 rs1002286 chr22:24257337 A/G cg06437703 chr8:37914619 EIF4EBP1 0.37 9.74 0.36 5.51e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9914544 0.966 rs1737943 chr17:18841590 A/G cg26378065 chr17:18585709 ZNF286B -0.36 -8.03 -0.3 4.86e-15 Educational attainment (years of education); BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg25036284 chr2:26402008 FAM59B -0.78 -12.16 -0.43 9.02e-31 Gut microbiome composition (summer); BRCA cis rs11955398 0.585 rs930864 chr5:60021688 C/T cg02684056 chr5:59996105 DEPDC1B -0.38 -9.13 -0.34 8.56e-19 Intelligence (multi-trait analysis); BRCA cis rs9814567 0.806 rs4245904 chr3:134321808 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg06115741 chr20:33292138 TP53INP2 0.5 10.41 0.38 1.45e-23 Coronary artery disease; BRCA cis rs910316 0.967 rs119076 chr14:75572419 G/T cg23033748 chr14:75592666 NEK9 -0.42 -10.19 -0.37 1.04e-22 Height; BRCA trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg03929089 chr4:120376271 NA 0.69 13.58 0.47 4.17e-37 Coronary artery disease; BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.92 0.33 4.74e-18 Tonsillectomy; BRCA cis rs826838 0.651 rs1843896 chr12:38612913 G/C cg26384229 chr12:38710491 ALG10B 0.58 13.31 0.47 7.62e-36 Heart rate; BRCA cis rs17092148 0.652 rs76324086 chr20:33079392 T/G cg16810054 chr20:33298113 TP53INP2 0.45 9.96 0.37 8.01e-22 Neuroticism; BRCA cis rs965469 0.532 rs6115865 chr20:3359303 A/G cg25506879 chr20:3388711 C20orf194 0.4 8.66 0.32 3.85e-17 IFN-related cytopenia; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg00149659 chr3:10157352 C3orf10 0.8 13.68 0.48 1.56e-37 Alzheimer's disease; BRCA cis rs400736 0.930 rs408320 chr1:8085328 T/C cg25007680 chr1:8021821 PARK7 0.47 11.85 0.42 2.06e-29 Response to antidepressants and depression; BRCA cis rs6964587 1.000 rs6951972 chr7:91689446 T/G cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.6 0.55 9.67e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs1215050 0.791 rs1585088 chr4:98675071 C/A cg05340658 chr4:99064831 C4orf37 -0.44 -10.07 -0.37 3.12e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7715806 0.500 rs17563995 chr5:75007556 A/G cg19683494 chr5:74908142 NA 0.5 8.06 0.3 3.72e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17095355 0.818 rs6584970 chr10:111847820 A/G cg00817464 chr10:111662876 XPNPEP1 -0.33 -8.06 -0.3 3.66e-15 Biliary atresia; BRCA trans rs1005277 0.579 rs2505196 chr10:38393563 G/A cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs344364 0.511 rs1657133 chr16:1950300 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -9.78 -0.36 3.77e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs7011049 1.000 rs72643588 chr8:53849335 C/T cg26025543 chr8:53854495 NA 0.53 9.06 0.34 1.59e-18 Systolic blood pressure; BRCA cis rs4944092 0.960 rs10400322 chr11:75910913 C/T cg04588336 chr11:75916460 WNT11 0.51 12.16 0.43 9.66e-31 PR interval; BRCA cis rs13392177 0.684 rs11682371 chr2:219079513 G/A cg00012203 chr2:219082015 ARPC2 -0.51 -10.46 -0.38 9.84e-24 Pyoderma gangrenosum in inflammatory bowel disease; BRCA trans rs61931739 0.517 rs1486882 chr12:34025896 A/G cg26384229 chr12:38710491 ALG10B 0.68 14.16 0.49 8.6e-40 Morning vs. evening chronotype; BRCA cis rs1401999 0.966 rs1533682 chr3:183634879 A/G cg20387954 chr3:183756860 HTR3D 0.43 9.76 0.36 4.69e-21 Anterior chamber depth; BRCA cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs9790314 0.747 rs7650703 chr3:160851639 T/C cg03342759 chr3:160939853 NMD3 -0.54 -10.51 -0.38 5.95e-24 Morning vs. evening chronotype; BRCA cis rs5167 0.504 rs7259679 chr19:45457306 C/T cg20090143 chr19:45452003 APOC2 0.27 7.88 0.3 1.37e-14 Blood protein levels; BRCA cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg22117172 chr7:91764530 CYP51A1 0.23 7.96 0.3 7.8e-15 Breast cancer; BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg00149659 chr3:10157352 C3orf10 0.66 10.19 0.37 1.05e-22 Alzheimer's disease; BRCA cis rs3096299 0.685 rs3803681 chr16:89544756 C/T cg08392591 chr16:89556376 ANKRD11 0.48 11.41 0.41 1.36e-27 Multiple myeloma (IgH translocation); BRCA cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg10802521 chr3:52805072 NEK4 -0.34 -9.3 -0.35 2.15e-19 Electroencephalogram traits; BRCA cis rs9527 0.571 rs7904113 chr10:104633114 G/T cg04362960 chr10:104952993 NT5C2 0.42 10.17 0.37 1.25e-22 Arsenic metabolism; BRCA cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.72e-31 Breast cancer; BRCA cis rs477692 0.618 rs7080419 chr10:131455235 A/G cg05714579 chr10:131428358 MGMT 0.41 8.68 0.32 3.37e-17 Response to temozolomide; BRCA cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.46 11.04 0.4 4.87e-26 IgG glycosylation; BRCA cis rs35306767 0.953 rs10904581 chr10:964685 A/T cg26597838 chr10:835615 NA 0.83 15.11 0.51 2.46e-44 Eosinophil percentage of granulocytes; BRCA cis rs875971 1.000 rs4718343 chr7:65874288 T/G cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.33e-67 Aortic root size; BRCA cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg23711669 chr6:146136114 FBXO30 0.8 18.97 0.6 5.73e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg27446573 chr6:127587934 RNF146 0.9 21.32 0.64 1.39e-76 Breast cancer; BRCA cis rs4555082 0.830 rs2255575 chr14:105727251 T/C cg10792982 chr14:105748885 BRF1 0.48 11.1 0.4 2.74e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs4891159 0.790 rs8085133 chr18:74144083 A/C cg24786174 chr18:74118243 ZNF516 -0.79 -21.83 -0.65 2.22e-79 Longevity; BRCA cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.7 0.33 2.72e-17 Iron status biomarkers; BRCA cis rs8141529 1.000 rs8141529 chr22:29269692 A/G cg15103426 chr22:29168792 CCDC117 0.51 11.96 0.43 7.15e-30 Lymphocyte counts; BRCA cis rs3820928 0.874 rs1996998 chr2:227840294 C/A cg11843606 chr2:227700838 RHBDD1 -0.37 -8.27 -0.31 7.79e-16 Pulmonary function; BRCA cis rs9649213 0.593 rs6465664 chr7:97921834 A/G cg24562669 chr7:97807699 LMTK2 0.45 12.28 0.44 2.88e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg04511125 chr2:88470314 THNSL2 0.94 13.56 0.47 5.22e-37 Plasma clusterin levels; BRCA cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg01849466 chr14:104193079 ZFYVE21 -0.49 -10.76 -0.39 5.99e-25 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9649213 0.593 rs2394854 chr7:98027306 A/G cg01877450 chr7:97915802 BRI3 -0.39 -8.85 -0.33 8.4e-18 Prostate cancer (SNP x SNP interaction); BRCA trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.93 -0.3 9.81e-15 Corneal astigmatism; BRCA cis rs8177253 0.828 rs8177259 chr3:133480388 T/C cg01448562 chr3:133502909 NA -0.6 -14.18 -0.49 7.03e-40 Iron status biomarkers; BRCA cis rs887829 0.570 rs11680450 chr2:234597483 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.29 -0.31 6.48e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs7131987 1.000 rs7131987 chr12:29406488 G/T cg09582351 chr12:29534625 ERGIC2 -0.4 -9.46 -0.35 5.71e-20 QT interval; BRCA cis rs30380 0.506 rs469735 chr5:96130014 T/C cg16492584 chr5:96139282 ERAP1 -0.46 -10.61 -0.39 2.37e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg05347473 chr6:146136440 FBXO30 0.43 8.63 0.32 4.97e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg22834771 chr12:69754056 YEATS4 -0.37 -8.68 -0.32 3.22e-17 Blood protein levels; BRCA trans rs12458462 0.892 rs58675823 chr18:77463672 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.45 -8.53 -0.32 1.02e-16 Monocyte count; BRCA cis rs12760731 0.720 rs10913535 chr1:178302914 C/A cg00404053 chr1:178313656 RASAL2 0.62 8.57 0.32 7.67e-17 Obesity-related traits; BRCA cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs7208859 0.573 rs56031503 chr17:29075665 T/C cg13385521 chr17:29058706 SUZ12P 0.77 12.06 0.43 2.56e-30 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg03354898 chr7:1950403 MAD1L1 0.38 8.57 0.32 8.07e-17 Bipolar disorder and schizophrenia; BRCA cis rs4780401 0.609 rs35902600 chr16:11800848 C/T cg01061890 chr16:11836724 TXNDC11 -0.56 -13.16 -0.46 3.54e-35 Rheumatoid arthritis; BRCA cis rs477692 0.905 rs509041 chr10:131424948 A/G cg05714579 chr10:131428358 MGMT 0.59 14.69 0.5 2.65e-42 Response to temozolomide; BRCA cis rs4588572 0.643 rs10474554 chr5:77799158 C/T cg11547950 chr5:77652471 NA -0.51 -8.77 -0.33 1.64e-17 Triglycerides; BRCA cis rs908922 0.676 rs1538083 chr1:152517116 A/G cg20991723 chr1:152506922 NA 0.39 8.75 0.33 1.95e-17 Hair morphology; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg26314531 chr2:26401878 FAM59B 0.96 16.34 0.54 2.18e-50 Gut microbiome composition (summer); BRCA cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg07930192 chr7:1003750 NA 0.48 10.42 0.38 1.42e-23 Longevity;Endometriosis; BRCA cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.83 0.36 2.52e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg21770322 chr7:97807741 LMTK2 0.41 10.97 0.4 8.81e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07256732 chr16:621771 PIGQ -0.36 -9.53 -0.35 3.11e-20 Height; BRCA cis rs4925386 0.759 rs2427293 chr20:60925859 A/G cg24112000 chr20:60950667 NA 0.48 9.52 0.35 3.51e-20 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs72634258 0.796 rs4369247 chr1:8168993 C/T cg00042356 chr1:8021962 PARK7 -0.5 -8.77 -0.33 1.61e-17 Inflammatory bowel disease; BRCA cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg04607235 chr12:12878440 APOLD1 -0.69 -10.73 -0.39 8.18e-25 Systemic lupus erythematosus; BRCA cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.13 0.4 2.05e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1707322 0.656 rs2991981 chr1:46057144 A/G cg03146154 chr1:46216737 IPP -0.49 -10.7 -0.39 1.05e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7011049 1.000 rs10958336 chr8:53841318 G/A cg26025543 chr8:53854495 NA 0.53 9.13 0.34 8.77e-19 Systolic blood pressure; BRCA cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.5 -0.44 2.99e-32 Developmental language disorder (linguistic errors); BRCA cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg24110177 chr3:50126178 RBM5 0.52 14.77 0.5 1.16e-42 Body mass index; BRCA cis rs362296 0.597 rs3129320 chr4:3265130 G/C cg06533319 chr4:3265114 C4orf44 0.31 8.39 0.32 3.07e-16 Parental longevity (mother's age at death); BRCA cis rs1983170 1.000 rs1983170 chr1:91986482 G/A cg25838465 chr1:92012736 NA 0.46 9.07 0.34 1.46e-18 Eosinophil percentage of white cells; BRCA cis rs17376456 0.757 rs10066431 chr5:93198204 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.4 0.32 3e-16 Diabetic retinopathy; BRCA cis rs17253792 0.822 rs79398217 chr14:56067350 C/T cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs7766436 0.961 rs6922960 chr6:22570189 T/C cg13666174 chr6:22585274 NA -0.43 -10.17 -0.37 1.28e-22 Coronary artery disease; BRCA cis rs2625529 0.824 rs12916694 chr15:72298140 C/T cg16672083 chr15:72433130 SENP8 -0.85 -17.53 -0.57 1.89e-56 Red blood cell count; BRCA cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg08999081 chr20:33150536 PIGU -0.33 -8.46 -0.32 1.82e-16 Glomerular filtration rate (creatinine); BRCA cis rs17401966 0.838 rs1556916 chr1:10403482 G/A cg03954927 chr1:10346856 KIF1B 0.44 13.98 0.48 6.18e-39 Hepatocellular carcinoma; BRCA cis rs11605275 1.000 rs74809393 chr11:20031520 C/A cg14835545 chr11:20032148 NAV2 -0.59 -9.32 -0.35 1.87e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21659725 chr3:3221576 CRBN -0.46 -9.72 -0.36 6.29e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9393777 0.513 rs13195210 chr6:26646521 C/T cg12826209 chr6:26865740 GUSBL1 0.6 10.47 0.38 8.57e-24 Intelligence (multi-trait analysis); BRCA cis rs2108225 0.872 rs7792139 chr7:107445433 G/A cg18560240 chr7:107437656 SLC26A3 -0.53 -11.05 -0.4 4.14e-26 Ulcerative colitis; BRCA cis rs7715806 0.500 rs17563610 chr5:74981322 A/T cg19683494 chr5:74908142 NA 0.54 8.6 0.32 6.21e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11190604 0.943 rs2495744 chr10:102329409 C/T cg07080220 chr10:102295463 HIF1AN 0.57 12.82 0.45 1.19e-33 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6088590 1.000 rs2076668 chr20:33437621 G/A cg08999081 chr20:33150536 PIGU 0.36 9.14 0.34 7.9e-19 Coronary artery disease; BRCA cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg26597838 chr10:835615 NA 1.3 22.1 0.66 8.2e-81 Eosinophil percentage of granulocytes; BRCA cis rs832540 0.669 rs832538 chr5:56200016 C/T cg18230493 chr5:56204884 C5orf35 -0.56 -12.03 -0.43 3.38e-30 Coronary artery disease; BRCA cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg18404041 chr3:52824283 ITIH1 -0.52 -16.76 -0.55 1.52e-52 Bipolar disorder; BRCA trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg23533926 chr12:111358616 MYL2 -0.43 -9.08 -0.34 1.35e-18 Extrinsic epigenetic age acceleration; BRCA cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg14784868 chr12:69753453 YEATS4 0.79 25.23 0.71 5.18e-98 Cerebrospinal fluid biomarker levels; BRCA cis rs1801251 1.000 rs6738386 chr2:233602028 T/C cg25237894 chr2:233734115 C2orf82 0.39 11.3 0.41 4.04e-27 Coronary artery disease; BRCA cis rs754466 1.000 rs12220328 chr10:79681482 G/C cg17075019 chr10:79541650 NA -0.57 -11.08 -0.4 3.2e-26 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs1493916 0.837 rs1027332 chr18:31410097 A/C cg27147174 chr7:100797783 AP1S1 -0.42 -8.48 -0.32 1.55e-16 Life satisfaction; BRCA cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg21918786 chr6:109611834 NA -0.34 -8.97 -0.33 3.36e-18 Reticulocyte fraction of red cells; BRCA cis rs6088590 0.930 rs6087618 chr20:33288407 C/T cg06115741 chr20:33292138 TP53INP2 0.51 11.26 0.41 5.92e-27 Coronary artery disease; BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg26314531 chr2:26401878 FAM59B 0.94 14.17 0.49 7.9e-40 Gut microbiome composition (summer); BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg03354898 chr7:1950403 MAD1L1 -0.47 -9.35 -0.35 1.42e-19 Bipolar disorder and schizophrenia; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.48 -9.06 -0.34 1.56e-18 Gut microbiome composition (summer); BRCA trans rs783540 0.609 rs803686 chr15:83219340 G/A cg16105309 chr15:79090380 ADAMTS7 0.34 9.24 0.34 3.54e-19 Schizophrenia; BRCA cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg08885076 chr2:99613938 TSGA10 0.45 10.6 0.39 2.7e-24 Chronic sinus infection; BRCA cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg27029518 chr18:72166324 CNDP2 -0.31 -8.77 -0.33 1.55e-17 Refractive error; BRCA cis rs6840360 0.615 rs72728173 chr4:152469373 C/T cg22705602 chr4:152727874 NA -0.33 -8.02 -0.3 5.22e-15 Intelligence (multi-trait analysis); BRCA cis rs926392 0.666 rs35166252 chr20:37695601 C/T cg16355469 chr20:37678765 NA 0.48 11.36 0.41 2.28e-27 Dialysis-related mortality; BRCA cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg10556349 chr10:835070 NA 0.59 8.09 0.3 2.95e-15 Eosinophil percentage of granulocytes; BRCA cis rs9814567 1.000 rs4367113 chr3:134287975 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.52 -0.61 6.57e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9486719 1.000 rs12208011 chr6:96991105 G/A cg06623918 chr6:96969491 KIAA0776 -0.78 -14.16 -0.49 8.73e-40 Migraine;Coronary artery disease; BRCA cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs4280164 0.887 rs11158634 chr14:24776457 C/G cg16194253 chr14:24768981 DHRS1;C14orf21 -0.46 -7.91 -0.3 1.15e-14 Parent of origin effect on language impairment (paternal); BRCA cis rs4727027 0.933 rs9718383 chr7:148857624 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 -0.53 -11.04 -0.4 4.79e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs312274 0.674 rs4420356 chr12:41210532 A/G cg17827154 chr12:41323612 CNTN1 0.34 8.2 0.31 1.31e-15 Metabolite levels (X-11787); BRCA cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.74e-36 Chronic sinus infection; BRCA cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg11764359 chr7:65958608 NA 0.57 11.92 0.43 1e-29 Calcium levels; BRCA cis rs13315871 0.858 rs78946071 chr3:58318523 G/T cg20936604 chr3:58311152 NA -0.66 -8.48 -0.32 1.5e-16 Cholesterol, total; BRCA cis rs798554 0.757 rs2533879 chr7:2859847 G/A cg12444411 chr7:2802554 GNA12 -0.39 -9.63 -0.36 1.43e-20 Height; BRCA cis rs1707322 0.752 rs11211152 chr1:46114157 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.62 10.74 0.39 7.32e-25 Platelet count; BRCA cis rs2625529 0.529 rs7183055 chr15:72377048 C/T cg16672083 chr15:72433130 SENP8 0.67 16.21 0.54 9.1e-50 Red blood cell count; BRCA cis rs801193 0.935 rs2286683 chr7:66129843 G/A cg18876405 chr7:65276391 NA -0.63 -15.65 -0.53 5.63e-47 Aortic root size; BRCA cis rs1506636 0.646 rs805776 chr7:123212561 T/C cg03229431 chr7:123269106 ASB15 -0.59 -12.49 -0.44 3.52e-32 Plateletcrit;Platelet count; BRCA cis rs4268898 0.760 rs11125535 chr2:24528114 T/C cg06627628 chr2:24431161 ITSN2 0.4 8.54 0.32 9.87e-17 Asthma; BRCA cis rs1712517 1.000 rs3123794 chr10:105033742 A/G cg05636881 chr10:105038444 INA 0.37 8.63 0.32 4.76e-17 Migraine; BRCA cis rs10992471 0.580 rs10992304 chr9:95085365 G/A cg14631576 chr9:95140430 CENPP -0.4 -9.7 -0.36 7.6e-21 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs9287719 0.967 rs10203785 chr2:10752508 T/C cg00105475 chr2:10696890 NA 0.44 10.32 0.38 3.4e-23 Prostate cancer; BRCA cis rs61931739 0.500 rs3924704 chr12:34557833 C/T cg06521331 chr12:34319734 NA -0.54 -9.73 -0.36 5.73e-21 Morning vs. evening chronotype; BRCA cis rs13046373 0.535 rs1961167 chr21:32030310 T/C cg14062083 chr21:31802829 KRTAP13-4 0.33 8.8 0.33 1.25e-17 HDL cholesterol; BRCA cis rs2836633 0.929 rs11701577 chr21:40028906 C/T cg05519781 chr21:40033154 ERG 0.46 9.86 0.36 1.9e-21 Coronary artery disease; BRCA cis rs778371 0.723 rs12993791 chr2:233690082 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -16.65 -0.55 5.95e-52 Schizophrenia; BRCA cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg06640241 chr16:89574553 SPG7 -0.55 -11.7 -0.42 8.79e-29 Multiple myeloma (IgH translocation); BRCA cis rs9815354 0.597 rs80066790 chr3:42000843 A/G cg03022575 chr3:42003672 ULK4 0.62 9.08 0.34 1.34e-18 Pulse pressure;Diastolic blood pressure; BRCA cis rs8180040 0.966 rs17784882 chr3:47544003 C/A cg16586182 chr3:47516702 SCAP 0.66 14.94 0.51 1.64e-43 Colorectal cancer; BRCA cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.27 -0.49 2.62e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs7980799 0.840 rs7315695 chr12:33551841 G/C cg26384229 chr12:38710491 ALG10B -0.4 -8.18 -0.31 1.49e-15 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs3768617 0.565 rs4233194 chr1:183060917 G/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.06 0.54 4.96e-49 Fuchs's corneal dystrophy; BRCA cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg12011299 chr4:100065546 ADH4 0.49 10.95 0.4 1.12e-25 Smoking initiation; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -12.03 -0.43 3.51e-30 Alzheimer's disease; BRCA cis rs8062405 0.755 rs1074631 chr16:28554108 A/G cg16576597 chr16:28551801 NUPR1 -0.33 -8.85 -0.33 8.75e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1008375 0.686 rs34338142 chr4:17626174 T/A cg15017067 chr4:17643749 FAM184B 0.29 8.82 0.33 1.06e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.48e-43 Aortic root size; BRCA cis rs11997175 0.583 rs56045827 chr8:33787015 G/A ch.8.33884649F chr8:33765107 NA 0.37 8.33 0.31 4.86e-16 Body mass index; BRCA cis rs12479064 0.724 rs2309618 chr2:99974473 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -11.95 -0.43 7.82e-30 Chronic sinus infection; BRCA cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 8.89 0.33 6.16e-18 Personality dimensions; BRCA cis rs17601876 0.786 rs2414100 chr15:51562420 T/A cg19946085 chr15:51559439 CYP19A1 -0.39 -11.74 -0.42 5.67e-29 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs875971 0.964 rs12668936 chr7:65914404 C/T cg18876405 chr7:65276391 NA 0.55 13.22 0.46 1.98e-35 Aortic root size; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg21784768 chr11:537496 LRRC56 -0.67 -8.48 -0.32 1.57e-16 Body mass index; BRCA cis rs72772090 0.539 rs72775817 chr5:96190709 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -11.04 -0.4 4.51e-26 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg10560079 chr2:191398806 TMEM194B 0.4 8.85 0.33 8.88e-18 Pulse pressure; BRCA cis rs11229555 0.598 rs1893902 chr11:58190747 A/G cg15696309 chr11:58395628 NA -0.45 -9.73 -0.36 6.06e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg18270830 chr10:32634957 EPC1 0.58 10.03 0.37 4.37e-22 Sexual dysfunction (female); BRCA cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg26314531 chr2:26401878 FAM59B -0.83 -15.43 -0.52 6.8e-46 Gut microbiome composition (summer); BRCA cis rs7647973 1.000 rs62259947 chr3:49439924 T/C cg07636037 chr3:49044803 WDR6 -0.77 -15.46 -0.52 4.7e-46 Menarche (age at onset); BRCA cis rs763121 0.853 rs2072798 chr22:39148483 G/A cg06544989 chr22:39130855 UNC84B 0.38 8.74 0.33 2.04e-17 Menopause (age at onset); BRCA cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg13334819 chr7:99746414 C7orf59 -0.45 -10.58 -0.39 3.16e-24 Coronary artery disease; BRCA cis rs7524258 0.903 rs6577424 chr1:7292417 C/T cg07173049 chr1:7289937 CAMTA1 -0.54 -13.37 -0.47 4.15e-36 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs769267 0.965 rs13964 chr19:19468710 C/G cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.51 -0.35 3.85e-20 Tonsillectomy; BRCA cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA trans rs10411161 0.702 rs11879319 chr19:52389592 C/T cg22319618 chr22:45562946 NUP50 -0.42 -8.05 -0.3 4.13e-15 Breast cancer; BRCA trans rs7824557 0.564 rs13260727 chr8:11232860 A/G cg06636001 chr8:8085503 FLJ10661 0.5 10.53 0.38 4.95e-24 Retinal vascular caliber; BRCA cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg03264133 chr6:25882463 NA -0.69 -16.33 -0.54 2.38e-50 Blood metabolite levels; BRCA cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.85 0.45 8.83e-34 Bipolar disorder; BRCA cis rs477692 0.870 rs512655 chr10:131424547 T/A cg05714579 chr10:131428358 MGMT 0.59 14.74 0.5 1.52e-42 Response to temozolomide; BRCA cis rs7772486 0.686 rs7744014 chr6:146123818 G/A cg13319975 chr6:146136371 FBXO30 -0.34 -7.94 -0.3 9.24e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10197940 0.686 rs12616688 chr2:152242099 C/G cg19508488 chr2:152266495 RIF1 0.52 10.01 0.37 5.44e-22 Lung cancer; BRCA cis rs727479 0.502 rs2304463 chr15:51508120 A/C cg19946085 chr15:51559439 CYP19A1 -0.3 -8.47 -0.32 1.72e-16 Estradiol levels; BRCA trans rs9325144 0.647 rs7487395 chr12:38865660 C/A cg23762105 chr12:34175262 ALG10 0.37 8.59 0.32 6.53e-17 Morning vs. evening chronotype; BRCA cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg26818010 chr10:134567672 INPP5A -0.63 -13.71 -0.48 1.1e-37 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg13047869 chr3:10149882 C3orf24 0.54 10.17 0.37 1.25e-22 Alzheimer's disease; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg04944784 chr2:26401820 FAM59B -0.9 -16.33 -0.54 2.3e-50 Gut microbiome composition (summer); BRCA cis rs708547 0.874 rs1713984 chr4:57886493 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.54 -9.19 -0.34 5.61e-19 Response to bleomycin (chromatid breaks); BRCA cis rs1215050 0.740 rs185468 chr4:98756242 C/T cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg08975724 chr8:8085496 FLJ10661 0.41 8.64 0.32 4.48e-17 Neuroticism; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.36 -8.2 -0.31 1.34e-15 Longevity;Endometriosis; BRCA cis rs6844506 1.000 rs6844506 chr4:185217148 C/T cg12654155 chr4:185238627 NA -0.45 -8.42 -0.32 2.54e-16 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); BRCA cis rs7707921 0.522 rs12374541 chr5:81491408 A/G cg15871215 chr5:81402204 ATG10 0.35 8.82 0.33 1.1e-17 Breast cancer; BRCA cis rs6878727 0.665 rs149628 chr5:123676213 C/T cg01806427 chr5:123737813 NA -0.36 -8.06 -0.3 3.85e-15 Breast cancer; BRCA cis rs7818345 1.000 rs11991105 chr8:19290655 C/T cg11303988 chr8:19266685 CSGALNACT1 0.3 7.85 0.3 1.72e-14 Language performance in older adults (adjusted for episodic memory); BRCA cis rs870825 0.616 rs6552810 chr4:185644143 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg18479299 chr3:125709523 NA -0.52 -8.77 -0.33 1.68e-17 Blood pressure (smoking interaction); BRCA cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.45 0.41 9.68e-28 Age-related macular degeneration (geographic atrophy); BRCA cis rs698833 0.926 rs1085485 chr2:44616728 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 9.1 0.34 1.11e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2304069 1.000 rs7737689 chr5:149396159 C/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.59 13.09 0.46 7.74e-35 HIV-1 control; BRCA cis rs111326718 1 rs111326718 chr10:104771211 A/AAAAAT cg04362960 chr10:104952993 NT5C2 0.43 10.55 0.39 4.27e-24 Reticulocyte count; BRCA cis rs7727544 0.735 rs274566 chr5:131715011 A/G cg24060327 chr5:131705240 SLC22A5 0.5 10.5 0.38 6.56e-24 Blood metabolite levels; BRCA cis rs11971779 0.553 rs7799742 chr7:139051878 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.22 0.37 8.22e-23 Diisocyanate-induced asthma; BRCA cis rs7075426 0.512 rs9633738 chr10:88183796 T/A cg07322936 chr10:88137208 NA -0.42 -8.19 -0.31 1.45e-15 Migraine without aura; BRCA trans rs11976180 1.000 rs2961134 chr7:143771062 A/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.42 -7.89 -0.3 1.35e-14 Obesity-related traits; BRCA cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg05025164 chr4:1340916 KIAA1530 0.4 9.06 0.34 1.62e-18 Longevity; BRCA cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg20848291 chr7:100343083 ZAN -0.59 -11.44 -0.41 1.11e-27 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs2836950 0.502 rs12627205 chr21:40630027 C/T cg11644478 chr21:40555479 PSMG1 -0.5 -10.65 -0.39 1.66e-24 Menarche (age at onset); BRCA cis rs11252926 0.563 rs10904173 chr10:462885 G/A cg16386425 chr10:429943 DIP2C 0.4 8.01 0.3 5.57e-15 Psychosis in Alzheimer's disease; BRCA trans rs60843830 1.000 rs6709534 chr2:217334 G/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 14.76 0.5 1.27e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs17401966 0.931 rs12137880 chr1:10388620 T/C cg03954927 chr1:10346856 KIF1B 0.48 15.31 0.52 2.52e-45 Hepatocellular carcinoma; BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg07308232 chr7:1071921 C7orf50 -0.39 -8.35 -0.31 4.16e-16 Longevity;Endometriosis; BRCA cis rs11608355 0.672 rs9943689 chr12:109890339 G/A cg05360138 chr12:110035743 NA 0.46 8.35 0.31 4.36e-16 Neuroticism; BRCA cis rs965469 1.000 rs6051831 chr20:3373712 G/T cg25506879 chr20:3388711 C20orf194 0.49 9.8 0.36 3.3e-21 IFN-related cytopenia; BRCA cis rs56399783 0.614 rs11765492 chr7:2771642 G/A cg23627948 chr7:2760692 NA 0.51 8.47 0.32 1.64e-16 Childhood ear infection; BRCA cis rs2425143 1.000 rs2425093 chr20:34306875 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Blood protein levels; BRCA cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg13628971 chr7:2884303 GNA12 0.37 8.36 0.31 3.98e-16 Height; BRCA cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg08975724 chr8:8085496 FLJ10661 0.37 8.08 0.3 3.33e-15 Neuroticism; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg26119090 chr2:26468346 HADHA;HADHB -1.05 -21.91 -0.66 8.14e-80 Gut microbiome composition (summer); BRCA trans rs7618501 0.516 rs2856236 chr3:50161717 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.3 -7.82 -0.3 2.17e-14 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs6083805 chr20:25317356 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.37 -0.35 1.21e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2282802 0.685 rs11745502 chr5:139558808 G/A cg26211634 chr5:139558579 C5orf32 -0.33 -7.98 -0.3 6.85e-15 Intelligence (multi-trait analysis); BRCA cis rs17023223 0.537 rs61806983 chr1:119731524 G/C cg05756136 chr1:119680316 WARS2 -0.42 -8.16 -0.31 1.8e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.72e-17 Developmental language disorder (linguistic errors); BRCA trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg03929089 chr4:120376271 NA -0.44 -8.25 -0.31 9.12e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg25204440 chr1:209979598 IRF6 0.42 8.44 0.32 2.13e-16 Cleft lip with or without cleft palate; BRCA cis rs2108225 1.000 rs6466191 chr7:107453511 A/T cg18560240 chr7:107437656 SLC26A3 -0.52 -10.37 -0.38 2.15e-23 Ulcerative colitis; BRCA cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg14829155 chr15:31115871 NA -0.43 -10.14 -0.37 1.74e-22 Huntington's disease progression; BRCA cis rs858239 0.932 rs858272 chr7:23276785 A/G cg23682824 chr7:23144976 KLHL7 0.39 9.66 0.36 1.06e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg06618935 chr21:46677482 NA -0.37 -8.23 -0.31 1.04e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2404602 0.569 rs2469249 chr15:76772062 C/T cg23625390 chr15:77176239 SCAPER -0.49 -10.68 -0.39 1.25e-24 Blood metabolite levels; BRCA cis rs16866061 0.517 rs7594223 chr2:225472985 T/C cg12698349 chr2:225449008 CUL3 0.45 10.93 0.4 1.34e-25 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs28830936 1.000 rs4924575 chr15:42096926 C/T cg17847044 chr15:42102381 MAPKBP1 -0.37 -10.12 -0.37 2.05e-22 Diastolic blood pressure; BRCA cis rs2439831 0.850 rs28513374 chr15:44125495 G/A cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.81 0.45 1.33e-33 Lung cancer in ever smokers; BRCA cis rs400736 0.894 rs172811 chr1:8039949 A/G cg25007680 chr1:8021821 PARK7 0.48 12.06 0.43 2.54e-30 Response to antidepressants and depression; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.59 9.55 0.35 2.66e-20 Renal function-related traits (BUN); BRCA cis rs2070488 0.804 rs2276541 chr3:38512779 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.64 0.57 4.76e-57 Electrocardiographic conduction measures; BRCA cis rs7677751 0.767 rs6832597 chr4:55076237 C/A cg17187183 chr4:55093834 PDGFRA 0.4 8.21 0.31 1.26e-15 Corneal astigmatism; BRCA cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg04756594 chr16:24857601 SLC5A11 0.48 10.08 0.37 2.94e-22 Intelligence (multi-trait analysis); BRCA cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg22875332 chr1:76189707 ACADM 0.63 13.07 0.46 9.1e-35 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2153535 0.607 rs9502722 chr6:8541483 C/T cg21535247 chr6:8435926 SLC35B3 0.41 9.15 0.34 7.49e-19 Motion sickness; BRCA cis rs10046574 0.831 rs28399231 chr7:135093154 G/A cg27474649 chr7:135195673 CNOT4 0.59 8.27 0.31 8e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 11.91 0.43 1.07e-29 Schizophrenia; BRCA cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg22800045 chr5:56110881 MAP3K1 0.55 10.53 0.38 5.14e-24 Initial pursuit acceleration; BRCA cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg01802117 chr1:53393560 SCP2 0.34 8.0 0.3 5.66e-15 Monocyte count; BRCA cis rs12216125 0.801 rs56107510 chr6:25987436 C/A cg17691542 chr6:26056736 HIST1H1C 0.61 12.35 0.44 1.37e-31 Iron status biomarkers; BRCA cis rs72781680 1.000 rs17762102 chr2:24085606 A/G cg08917208 chr2:24149416 ATAD2B 0.91 13.46 0.47 1.5e-36 Lymphocyte counts; BRCA cis rs7707921 0.767 rs862244 chr5:81586801 G/A cg15871215 chr5:81402204 ATG10 0.35 8.29 0.31 6.7e-16 Breast cancer; BRCA cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg16405210 chr4:1374714 KIAA1530 -0.47 -10.83 -0.39 3.33e-25 Longevity; BRCA cis rs6604026 0.740 rs7536563 chr1:93349046 A/G cg17283838 chr1:93427260 FAM69A -0.4 -8.31 -0.31 5.64e-16 Multiple sclerosis; BRCA cis rs2075371 0.897 rs1646702 chr7:134000177 C/G cg11752832 chr7:134001865 SLC35B4 0.52 13.55 0.47 6.19e-37 Mean platelet volume; BRCA cis rs10911251 0.508 rs944970 chr1:183112566 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA cis rs2011503 0.891 rs2965186 chr19:19497195 T/G cg15839431 chr19:19639596 YJEFN3 0.41 9.13 0.34 9.05e-19 Bipolar disorder; BRCA cis rs6580649 0.941 rs7957764 chr12:48429701 C/T cg05342945 chr12:48394962 COL2A1 0.42 8.06 0.3 3.85e-15 Lung cancer; BRCA trans rs11098499 0.863 rs3775844 chr4:120428033 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.16 0.31 1.83e-15 Corneal astigmatism; BRCA cis rs10949834 0.504 rs12539781 chr7:73568425 C/T cg07137043 chr7:73588983 EIF4H -0.63 -10.42 -0.38 1.37e-23 Verbal memory performance (residualized delayed recall change); BRCA cis rs2880765 0.835 rs4280192 chr15:86043020 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.48 -0.32 1.57e-16 Coronary artery disease; BRCA cis rs10870270 0.956 rs10781555 chr10:133745720 G/A cg17892150 chr10:133769511 PPP2R2D -0.74 -15.78 -0.53 1.27e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs35146811 1.000 rs35146811 chr7:99720994 A/C cg22906224 chr7:99728672 NA 0.5 9.47 0.35 5.42e-20 Coronary artery disease; BRCA cis rs4595586 0.545 rs12826080 chr12:39387772 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.44 0.35 6.82e-20 Morning vs. evening chronotype; BRCA cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg06494592 chr3:125709126 NA -0.51 -7.9 -0.3 1.18e-14 Blood pressure (smoking interaction); BRCA cis rs9814567 1.000 rs6769885 chr3:134286913 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs2204008 0.606 rs1581358 chr12:38391582 G/T cg06521331 chr12:34319734 NA -0.52 -9.25 -0.34 3.25e-19 Bladder cancer; BRCA cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg00101154 chr16:420108 MRPL28 -0.43 -9.36 -0.35 1.34e-19 Bone mineral density (spine);Bone mineral density; BRCA cis rs1153858 0.725 rs74572151 chr15:45647526 T/G cg21132104 chr15:45694354 SPATA5L1 0.73 16.07 0.54 4.83e-49 Homoarginine levels; BRCA cis rs72781680 0.611 rs55983206 chr2:24333995 A/C cg20701182 chr2:24300061 SF3B14 0.71 13.25 0.46 1.44e-35 Lymphocyte counts; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg04025307 chr7:1156635 C7orf50 0.59 9.36 0.35 1.33e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.29e-40 Motion sickness; BRCA trans rs7786808 0.552 rs896762 chr7:158182029 A/G cg02030672 chr11:45687055 CHST1 -0.41 -9.1 -0.34 1.17e-18 Obesity-related traits; BRCA cis rs9733 0.621 rs6669122 chr1:150591732 A/G cg13175981 chr1:150552382 MCL1 0.53 11.66 0.42 1.25e-28 Tonsillectomy; BRCA cis rs2576037 0.899 rs2246877 chr18:44577005 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.38 -8.05 -0.3 4.15e-15 Personality dimensions; BRCA cis rs597539 0.652 rs611046 chr11:68631704 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 16.24 0.54 6.81e-50 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.58 0.55 1.29e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs10197940 0.662 rs4592848 chr2:152337822 G/A cg06191203 chr2:152266755 RIF1 -0.42 -12.09 -0.43 1.95e-30 Lung cancer; BRCA cis rs6981523 0.500 rs4412337 chr8:11072020 C/T cg21775007 chr8:11205619 TDH 0.48 9.16 0.34 6.76e-19 Neuroticism; BRCA cis rs11608355 0.545 rs2302706 chr12:109894028 A/G cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs16854884 0.657 rs1979910 chr3:143710268 A/C cg06585982 chr3:143692056 C3orf58 0.44 9.07 0.34 1.39e-18 Economic and political preferences (feminism/equality); BRCA cis rs61931739 0.500 rs56056630 chr12:34543465 T/C cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA cis rs8177253 0.574 rs6775042 chr3:133442245 G/T cg12373951 chr3:133503437 NA 0.34 8.03 0.3 4.6e-15 Iron status biomarkers; BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg08280861 chr8:58055591 NA 0.56 8.78 0.33 1.49e-17 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.599 rs7967598 chr12:38540760 C/T cg26384229 chr12:38710491 ALG10B -0.43 -10.21 -0.37 8.89e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs7246657 0.550 rs9941475 chr19:38064517 C/T cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg16606324 chr3:10149918 C3orf24 0.56 11.08 0.4 3.11e-26 Alzheimer's disease; BRCA cis rs6840360 0.593 rs4696286 chr4:152606547 G/A cg22705602 chr4:152727874 NA -0.37 -10.08 -0.37 2.74e-22 Intelligence (multi-trait analysis); BRCA cis rs6840360 0.615 rs56319216 chr4:152463716 C/T cg22705602 chr4:152727874 NA -0.33 -8.02 -0.3 5.22e-15 Intelligence (multi-trait analysis); BRCA cis rs6687430 0.526 rs7555790 chr1:10613167 A/G cg17425144 chr1:10567563 PEX14 -0.57 -13.44 -0.47 1.96e-36 Hand grip strength; BRCA cis rs7766436 0.848 rs16901663 chr6:22598054 T/C cg13666174 chr6:22585274 NA -0.44 -9.56 -0.35 2.43e-20 Coronary artery disease; BRCA cis rs208520 1.000 rs208537 chr6:66963544 A/G cg07460842 chr6:66804631 NA -0.86 -14.3 -0.49 1.93e-40 Exhaled nitric oxide output; BRCA cis rs2439831 0.850 rs12441984 chr15:44126285 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.53 9.89 0.36 1.53e-21 Lung cancer in ever smokers; BRCA cis rs1994135 0.617 rs12821909 chr12:33723466 T/C cg06521331 chr12:34319734 NA -0.53 -9.28 -0.34 2.62e-19 Resting heart rate; BRCA cis rs11955398 0.625 rs11745077 chr5:59955716 C/T cg02684056 chr5:59996105 DEPDC1B 0.38 8.86 0.33 8.04e-18 Intelligence (multi-trait analysis); BRCA cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg02079420 chr8:82753780 SNX16 -0.36 -7.92 -0.3 1.05e-14 Diastolic blood pressure; BRCA cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -15.04 -0.51 5.54e-44 Chronic sinus infection; BRCA cis rs7777484 0.517 rs2644306 chr7:2831602 A/G cg19717773 chr7:2847554 GNA12 -0.48 -11.12 -0.4 2.22e-26 Height; BRCA cis rs7833790 0.929 rs28464834 chr8:82797356 A/T cg17211192 chr8:82754475 SNX16 0.57 10.31 0.38 3.8e-23 Diastolic blood pressure; BRCA cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs9325144 0.560 rs7314632 chr12:38636979 C/T cg26384229 chr12:38710491 ALG10B -0.5 -12.92 -0.46 4.19e-34 Morning vs. evening chronotype; BRCA cis rs514406 0.929 rs554301 chr1:53321948 A/T cg16325326 chr1:53192061 ZYG11B -0.69 -17.39 -0.57 9.4e-56 Monocyte count; BRCA cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.94 0.43 8.34e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.765 rs12468807 chr2:99691994 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.52 -9.14 -0.34 8.51e-19 Schizophrenia; BRCA cis rs473651 1.000 rs473651 chr2:239335401 A/C cg03560586 chr2:239334908 ASB1 -0.52 -11.48 -0.41 7.11e-28 Multiple system atrophy; BRCA trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21659725 chr3:3221576 CRBN -0.71 -21.61 -0.65 3.69e-78 Intelligence (multi-trait analysis); BRCA trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg08975724 chr8:8085496 FLJ10661 0.4 8.24 0.31 9.92e-16 Neuroticism; BRCA trans rs7647973 0.588 rs9883000 chr3:49667691 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.98 -0.3 6.61e-15 Menarche (age at onset); BRCA cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.58e-29 Bipolar disorder; BRCA cis rs7246657 1.000 rs6508710 chr19:37749886 A/G cg23950597 chr19:37808831 NA -0.62 -10.94 -0.4 1.13e-25 Coronary artery calcification; BRCA cis rs2806561 0.894 rs1738475 chr1:23536891 C/G cg19743168 chr1:23544995 NA 0.47 11.73 0.42 6.8e-29 Height; BRCA cis rs3739998 0.647 rs7920682 chr10:30317826 C/T cg12786570 chr10:30316432 KIAA1462 -0.43 -9.29 -0.34 2.39e-19 Coronary heart disease; BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26314531 chr2:26401878 FAM59B -0.64 -11.13 -0.4 2.02e-26 Gut microbiome composition (summer); BRCA cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg26395211 chr5:140044315 WDR55 0.37 8.61 0.32 5.86e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs6089584 0.566 rs2181589 chr20:60622817 C/T cg13770153 chr20:60521292 NA 0.37 8.84 0.33 9.03e-18 Body mass index; BRCA cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.943 rs10403613 chr19:37844306 C/T cg23950597 chr19:37808831 NA -0.72 -12.54 -0.44 2e-32 Coronary artery calcification; BRCA cis rs10411936 0.692 rs62118141 chr19:16602808 T/C cg10248733 chr19:16607483 C19orf44;CALR3 0.45 9.52 0.35 3.42e-20 White blood cell count;Multiple sclerosis; BRCA cis rs910316 1.000 rs175425 chr14:75626131 T/C cg08847533 chr14:75593920 NEK9 -0.88 -22.45 -0.66 9.64e-83 Height; BRCA cis rs10256972 0.967 rs4723338 chr7:1036241 A/G cg15112475 chr7:1198522 ZFAND2A -0.37 -7.92 -0.3 1.06e-14 Longevity;Endometriosis; BRCA cis rs757081 0.667 rs569780 chr11:17206745 C/T cg15432903 chr11:17409602 KCNJ11 -0.46 -8.58 -0.32 7.23e-17 Systolic blood pressure; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg09436375 chr6:42928200 GNMT -0.28 -10.56 -0.39 3.82e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1468333 1.000 rs423258 chr5:137475787 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.45 8.66 0.32 3.83e-17 Resting heart rate; BRCA cis rs11098499 0.954 rs9685777 chr4:120365965 C/A cg09307838 chr4:120376055 NA 0.74 15.98 0.53 1.38e-48 Corneal astigmatism; BRCA cis rs9291683 0.588 rs6857693 chr4:10018435 G/A cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.99e-35 Bone mineral density; BRCA cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg06060754 chr5:176797920 RGS14 0.59 11.11 0.4 2.32e-26 Hemoglobin concentration;Hematocrit; BRCA cis rs11874712 1.000 rs11082509 chr18:43655010 G/A cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.01 0.3 5.44e-15 Migraine - clinic-based; BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.79 0.36 3.53e-21 Gut microbiome composition (summer); BRCA cis rs4285028 0.699 rs73855465 chr3:121574219 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.73 -13.4 -0.47 2.99e-36 Multiple sclerosis; BRCA trans rs6601450 0.547 rs10105843 chr8:10197863 A/G cg15556689 chr8:8085844 FLJ10661 0.39 10.34 0.38 2.72e-23 Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg20887711 chr4:1340912 KIAA1530 0.72 16.1 0.54 3.33e-49 Longevity; BRCA cis rs4906332 0.811 rs2021965 chr14:103997248 C/A cg19000871 chr14:103996768 TRMT61A 0.47 10.48 0.38 8.35e-24 Coronary artery disease; BRCA cis rs17601876 0.814 rs28674681 chr15:51559917 A/C cg19946085 chr15:51559439 CYP19A1 -0.39 -11.87 -0.42 1.74e-29 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg10253484 chr15:75165896 SCAMP2 -0.54 -11.03 -0.4 5.11e-26 Breast cancer; BRCA cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg17845761 chr1:175162550 KIAA0040 -0.25 -9.38 -0.35 1.14e-19 Alcohol dependence; BRCA cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg18351406 chr4:77819688 ANKRD56 0.61 13.39 0.47 3.13e-36 Emphysema distribution in smoking; BRCA cis rs10782582 0.609 rs2881785 chr1:76318096 T/C cg03433033 chr1:76189801 ACADM -0.42 -8.44 -0.32 2.17e-16 Daytime sleep phenotypes; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 14.14 0.49 1.08e-39 Alzheimer's disease; BRCA cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg11843238 chr5:131593191 PDLIM4 0.35 7.99 0.3 6.49e-15 Breast cancer; BRCA cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg26248373 chr2:1572462 NA -0.52 -10.26 -0.38 6e-23 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs13191362 1.000 rs4489133 chr6:163137793 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.42 0.32 2.44e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7493 0.950 rs7785705 chr7:95033803 A/T cg17330251 chr7:94953956 PON1 -0.41 -8.7 -0.33 2.84e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12292205 chr6:26970375 C6orf41 -0.46 -7.87 -0.3 1.51e-14 Intelligence (multi-trait analysis); BRCA cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg03433033 chr1:76189801 ACADM -0.51 -10.05 -0.37 3.79e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2051211 1.000 rs17037804 chr3:38559215 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.47 -9.72 -0.36 6.34e-21 QRS duration; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg26314531 chr2:26401878 FAM59B 0.96 16.33 0.54 2.39e-50 Gut microbiome composition (summer); BRCA cis rs6701037 0.681 rs13374887 chr1:175131962 A/T cg00321850 chr1:175162397 KIAA0040 0.41 11.2 0.4 1.07e-26 Alcohol dependence; BRCA cis rs59918340 0.692 rs6983780 chr8:142231944 G/A cg23750338 chr8:142222470 SLC45A4 0.51 12.48 0.44 3.85e-32 Immature fraction of reticulocytes; BRCA cis rs2439831 0.618 rs8023508 chr15:44176103 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.44 -9.49 -0.35 4.49e-20 Lung cancer in ever smokers; BRCA cis rs9467773 0.595 rs13207371 chr6:26591074 G/A cg09904177 chr6:26538194 HMGN4 0.44 12.79 0.45 1.65e-33 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.869 rs34791781 chr7:91532720 C/T cg17063962 chr7:91808500 NA -0.51 -11.93 -0.43 9.32e-30 Breast cancer; BRCA cis rs7149337 1.000 rs4901103 chr14:51746873 C/T cg23942311 chr14:51606299 NA 0.36 9.62 0.36 1.5e-20 Cancer; BRCA cis rs9467773 0.838 rs3734540 chr6:26463321 A/C cg09904177 chr6:26538194 HMGN4 0.48 13.8 0.48 4.36e-38 Intelligence (multi-trait analysis); BRCA cis rs9986765 0.867 rs1994498 chr7:142816448 C/T cg22531018 chr7:142981779 TMEM139 0.59 9.8 0.36 3.28e-21 Cancer;Dermatomyositis; BRCA cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.81 -0.36 2.89e-21 Developmental language disorder (linguistic errors); BRCA cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg14689365 chr7:158441557 NCAPG2 0.43 8.93 0.33 4.55e-18 Height; BRCA cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg08807101 chr21:30365312 RNF160 -0.44 -9.33 -0.35 1.66e-19 Dental caries; BRCA cis rs11971779 0.680 rs6467843 chr7:139070523 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA trans rs2204008 0.580 rs11174421 chr12:38105138 A/G cg06521331 chr12:34319734 NA -0.5 -8.76 -0.33 1.78e-17 Bladder cancer; BRCA cis rs9549260 0.753 rs9549238 chr13:41179321 G/A cg21288729 chr13:41239152 FOXO1 0.54 8.68 0.32 3.38e-17 Red blood cell count; BRCA cis rs9790314 0.846 rs6791213 chr3:161033721 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -10.3 -0.38 3.93e-23 Morning vs. evening chronotype; BRCA cis rs9487051 1.000 rs11757567 chr6:109614713 G/A cg21918786 chr6:109611834 NA -0.45 -12.05 -0.43 2.77e-30 Reticulocyte fraction of red cells; BRCA cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg24229701 chr12:130821962 PIWIL1 0.39 8.89 0.33 6.08e-18 Menopause (age at onset); BRCA trans rs11098499 0.954 rs35063680 chr4:120387102 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg02297831 chr4:17616191 MED28 0.37 8.55 0.32 9.21e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6942756 0.747 rs692432 chr7:129113287 G/A cg02491457 chr7:128862824 NA -0.55 -11.37 -0.41 2.05e-27 White matter hyperintensity burden; BRCA cis rs1797081 1.000 rs780634 chr10:16864327 T/G cg23933602 chr10:16859644 RSU1 0.96 28.61 0.75 1.68e-116 Platelet distribution width; BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.49 10.14 0.37 1.65e-22 Tonsillectomy; BRCA cis rs813218 0.523 rs669676 chr3:99448852 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -9.01 -0.34 2.33e-18 Orofacial clefts; BRCA cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg19077165 chr18:44547161 KATNAL2 -0.61 -13.85 -0.48 2.44e-38 Personality dimensions; BRCA cis rs651907 0.535 rs2290859 chr3:101525625 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 13.63 0.47 2.65e-37 Colorectal cancer; BRCA cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg26597838 chr10:835615 NA 0.97 17.03 0.56 6.77e-54 Eosinophil percentage of granulocytes; BRCA cis rs7937682 0.575 rs7107213 chr11:111750430 A/G cg09085632 chr11:111637200 PPP2R1B 0.73 16.08 0.54 4.39e-49 Primary sclerosing cholangitis; BRCA cis rs2243480 1.000 rs2707831 chr7:66062511 G/A cg18252515 chr7:66147081 NA -1.04 -15.52 -0.52 2.55e-46 Diabetic kidney disease; BRCA cis rs12497850 0.931 rs7431710 chr3:48935583 G/A cg06212747 chr3:49208901 KLHDC8B 0.49 10.2 0.37 1.02e-22 Parkinson's disease; BRCA cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg14036092 chr11:66035641 RAB1B 0.39 10.15 0.37 1.5e-22 Gout; BRCA cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs1048238 0.935 rs761760 chr1:16342419 A/G cg06159980 chr1:16340746 HSPB7 -0.38 -8.84 -0.33 9.14e-18 Systolic blood pressure; BRCA trans rs783540 0.656 rs783524 chr15:83284144 A/C cg18393722 chr15:85113863 UBE2QP1 -0.32 -8.77 -0.33 1.66e-17 Schizophrenia; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg00106254 chr7:1943704 MAD1L1 -0.32 -8.02 -0.3 4.96e-15 Bipolar disorder and schizophrenia; BRCA cis rs9486719 0.947 rs11757102 chr6:96885073 G/A cg06623918 chr6:96969491 KIAA0776 -0.72 -12.98 -0.46 2.26e-34 Migraine;Coronary artery disease; BRCA cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg16322792 chr1:120165303 ZNF697 0.58 15.24 0.52 5.78e-45 Systemic lupus erythematosus; BRCA cis rs6460942 0.749 rs74834695 chr7:12464779 G/A cg06484146 chr7:12443880 VWDE -0.78 -11.1 -0.4 2.74e-26 Coronary artery disease; BRCA cis rs2732480 0.523 rs34286639 chr12:48629044 C/T cg04545296 chr12:48745243 ZNF641 0.24 7.92 0.3 1.06e-14 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg11890956 chr21:40555474 PSMG1 -0.6 -13.22 -0.46 1.9e-35 Menarche (age at onset); BRCA cis rs7715811 1.000 rs9688222 chr5:13760906 C/A cg07548982 chr5:13769939 DNAH5 -0.38 -8.35 -0.31 4.39e-16 Subclinical atherosclerosis traits (other); BRCA cis rs10128251 0.962 rs10752281 chr10:5711220 C/T cg24097872 chr10:5724021 NA -0.52 -11.62 -0.42 1.81e-28 Childhood ear infection; BRCA cis rs775227 0.574 rs13086266 chr3:113083535 T/A cg18753928 chr3:113234510 CCDC52 -0.59 -9.18 -0.34 6.12e-19 Dental caries; BRCA cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.77 -0.33 1.68e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg18402987 chr7:1209562 NA 0.58 11.39 0.41 1.76e-27 Longevity;Endometriosis; BRCA cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg05623727 chr3:50126028 RBM5 -0.37 -8.66 -0.32 3.94e-17 Menarche (age at onset); BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.02 -0.3 5.11e-15 Menopause (age at onset); BRCA trans rs9291683 0.620 rs4444830 chr4:10124819 A/G cg26043149 chr18:55253948 FECH -0.42 -8.74 -0.33 2.09e-17 Bone mineral density; BRCA cis rs654128 0.640 rs339339 chr6:117214866 A/C cg12892004 chr6:117198278 RFX6 -0.44 -8.02 -0.3 4.96e-15 Telomere length; BRCA cis rs8028182 0.636 rs4886707 chr15:75755467 C/T cg20655648 chr15:75932815 IMP3 0.42 8.39 0.31 3.15e-16 Sudden cardiac arrest; BRCA cis rs10754283 0.967 rs7528433 chr1:90114071 T/C cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.24e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.71 -16.69 -0.55 3.42e-52 Axial length; BRCA cis rs1862618 0.671 rs2591968 chr5:56233541 A/G cg12311346 chr5:56204834 C5orf35 -0.62 -13.0 -0.46 1.9e-34 Initial pursuit acceleration; BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.04e-36 Developmental language disorder (linguistic errors); BRCA cis rs6088813 1.000 rs6087705 chr20:34001250 C/T cg14752227 chr20:34000481 UQCC -0.38 -8.06 -0.3 3.7e-15 Height; BRCA trans rs8002861 0.641 rs2028813 chr13:44422126 G/T cg17145862 chr1:211918768 LPGAT1 0.47 10.5 0.38 6.61e-24 Leprosy; BRCA cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg24596788 chr1:163392923 NA -0.36 -9.3 -0.35 2.22e-19 Motion sickness; BRCA cis rs775227 0.574 rs79709668 chr3:113161265 G/A cg18753928 chr3:113234510 CCDC52 -0.53 -8.83 -0.33 9.94e-18 Dental caries; BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg00149659 chr3:10157352 C3orf10 0.8 13.77 0.48 5.57e-38 Alzheimer's disease; BRCA cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg07414643 chr4:187882934 NA 0.28 9.61 0.36 1.64e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.738 rs17361749 chr1:46806480 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.47 0.35 5.28e-20 Menopause (age at onset); BRCA cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg18876405 chr7:65276391 NA -0.58 -13.8 -0.48 3.98e-38 Aortic root size; BRCA cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.38 0.57 1.12e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.721 rs11211149 chr1:46112218 T/C cg03146154 chr1:46216737 IPP 0.52 11.73 0.42 6.32e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.5 -11.42 -0.41 1.32e-27 Electroencephalogram traits; BRCA cis rs1577917 1.000 rs2166663 chr6:86593896 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -10.97 -0.4 9.25e-26 Response to antipsychotic treatment; BRCA cis rs10927875 0.793 rs1763619 chr1:16326935 A/G cg21385522 chr1:16154831 NA 0.56 10.36 0.38 2.45e-23 Dilated cardiomyopathy; BRCA cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg03146154 chr1:46216737 IPP 0.46 10.2 0.37 9.95e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7267979 0.868 rs6138546 chr20:25216534 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.39 0.31 3.13e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs514406 0.505 rs431459 chr1:53183230 T/G cg24675658 chr1:53192096 ZYG11B -0.66 -14.46 -0.5 3.47e-41 Monocyte count; BRCA cis rs7584330 0.554 rs2325838 chr2:238386515 C/A cg08992911 chr2:238395768 MLPH 0.59 10.3 0.38 3.98e-23 Prostate cancer; BRCA cis rs2153535 0.584 rs62395678 chr6:8371689 C/T cg07606381 chr6:8435919 SLC35B3 -0.57 -12.19 -0.43 7.19e-31 Motion sickness; BRCA cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg18876405 chr7:65276391 NA -0.48 -10.46 -0.38 9.72e-24 Aortic root size; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg22907277 chr7:1156413 C7orf50 0.6 11.75 0.42 5.5e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg13271783 chr10:134563150 INPP5A -0.5 -9.45 -0.35 6.18e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg06618935 chr21:46677482 NA -0.37 -8.08 -0.3 3.29e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9399135 0.527 rs61738492 chr6:135282771 G/A cg24558204 chr6:135376177 HBS1L 0.57 15.19 0.52 1.01e-44 Red blood cell count; BRCA cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs12477438 0.834 rs6757019 chr2:99676936 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg23978390 chr7:1156363 C7orf50 0.48 11.42 0.41 1.31e-27 Longevity;Endometriosis; BRCA cis rs6500602 0.673 rs4786512 chr16:4573040 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.38 8.06 0.3 3.8e-15 Schizophrenia; BRCA cis rs10504229 0.679 rs7813252 chr8:58136389 C/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg22920501 chr2:26401640 FAM59B -0.65 -11.69 -0.42 9.3e-29 Gut microbiome composition (summer); BRCA cis rs3806843 1.000 rs6885319 chr5:140200611 A/C cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.82 -0.36 2.65e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg02951883 chr7:2050386 MAD1L1 -0.58 -15.11 -0.51 2.42e-44 Bipolar disorder and schizophrenia; BRCA cis rs8005677 0.962 rs11157931 chr14:23403193 A/C cg01529538 chr14:23388837 RBM23 0.41 10.91 0.4 1.58e-25 Cognitive ability (multi-trait analysis); BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg23978390 chr7:1156363 C7orf50 0.37 8.9 0.33 5.64e-18 Longevity;Endometriosis; BRCA cis rs7577696 0.597 rs6756085 chr2:32336522 A/G cg02381751 chr2:32503542 YIPF4 -0.42 -7.83 -0.3 2.06e-14 Inflammatory biomarkers; BRCA cis rs11229555 0.645 rs12269928 chr11:58184358 T/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.78 12.96 0.46 2.88e-34 Platelet count; BRCA cis rs6580649 0.941 rs4760618 chr12:48434767 G/A cg05342945 chr12:48394962 COL2A1 0.42 8.12 0.31 2.33e-15 Lung cancer; BRCA cis rs28374715 0.532 rs11854632 chr15:41682094 A/G cg18705301 chr15:41695430 NDUFAF1 1.07 27.94 0.74 7.36e-113 Ulcerative colitis; BRCA cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.93 0.3 9.65e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs965469 0.724 rs6051818 chr20:3362033 T/C cg25506879 chr20:3388711 C20orf194 -0.45 -9.08 -0.34 1.37e-18 IFN-related cytopenia; BRCA cis rs12497850 0.931 rs7621015 chr3:49016056 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.57 0.35 2.39e-20 Parkinson's disease; BRCA trans rs1005277 0.579 rs1780145 chr10:38537070 A/G cg17830980 chr10:43048298 ZNF37B -0.55 -13.28 -0.47 1.08e-35 Extrinsic epigenetic age acceleration; BRCA cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg26408565 chr15:76604113 ETFA -0.47 -10.27 -0.38 5.06e-23 Blood metabolite levels; BRCA cis rs11792861 1.000 rs11792861 chr9:111809295 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 7.83 0.3 2.08e-14 Menarche (age at onset); BRCA cis rs1059312 0.808 rs4482069 chr12:129294252 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.78 -19.18 -0.6 4.14e-65 Systemic lupus erythematosus; BRCA cis rs10751667 0.643 rs12278229 chr11:946985 A/G cg10932868 chr11:921992 NA 0.49 12.63 0.45 7.98e-33 Alzheimer's disease (late onset); BRCA cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg24450063 chr1:156163899 SLC25A44 0.89 17.49 0.57 2.83e-56 Testicular germ cell tumor; BRCA cis rs8062405 1.000 rs12443881 chr16:28841777 C/T cg09754948 chr16:28834200 ATXN2L 0.46 8.65 0.32 4.12e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs57221529 0.709 rs111352378 chr5:577079 G/A cg11887960 chr12:57824829 NA 0.55 8.57 0.32 7.74e-17 Lung disease severity in cystic fibrosis; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.16 -0.46 3.75e-35 Lymphocyte counts; BRCA cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs13108904 0.846 rs4974574 chr4:1224811 A/G cg00684032 chr4:1343700 KIAA1530 0.36 8.64 0.32 4.56e-17 Obesity-related traits; BRCA trans rs11976180 1.000 rs2961120 chr7:143756585 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.48 -8.8 -0.33 1.23e-17 Obesity-related traits; BRCA trans rs1493916 0.837 rs4997493 chr18:31407302 C/T cg15819921 chr19:927150 ARID3A -0.41 -8.07 -0.3 3.37e-15 Life satisfaction; BRCA cis rs11123610 0.520 rs35752035 chr2:3721353 G/C cg19052272 chr2:3704530 ALLC -0.46 -10.42 -0.38 1.36e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg11644478 chr21:40555479 PSMG1 -0.68 -15.35 -0.52 1.74e-45 Cognitive function; BRCA cis rs4803468 0.967 rs892044 chr19:41903671 A/G cg09537434 chr19:41945824 ATP5SL -0.98 -24.01 -0.69 2.89e-91 Height; BRCA cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg05985134 chr18:33552581 C18orf21 0.64 12.21 0.43 5.7e-31 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs1493916 0.748 rs2040203 chr18:31307420 G/T cg15819921 chr19:927150 ARID3A -0.42 -8.27 -0.31 7.78e-16 Life satisfaction; BRCA cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg16584676 chr17:46985605 UBE2Z 0.37 8.69 0.33 2.92e-17 Type 2 diabetes; BRCA cis rs2153535 0.580 rs9405391 chr6:8466548 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.51 0.38 6.01e-24 Motion sickness; BRCA cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg23711669 chr6:146136114 FBXO30 -0.76 -17.27 -0.56 3.75e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs9942416 0.660 rs1817869 chr5:74989037 T/C cg19683494 chr5:74908142 NA 0.48 9.01 0.34 2.33e-18 Age-related disease endophenotypes; BRCA cis rs7582180 0.591 rs11674569 chr2:101010860 G/A cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.15e-14 Intelligence (multi-trait analysis); BRCA cis rs9810890 1.000 rs77303548 chr3:128454766 C/T cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs7592578 0.713 rs60915953 chr2:191331304 G/C cg10560079 chr2:191398806 TMEM194B -0.75 -12.85 -0.45 8.91e-34 Diastolic blood pressure; BRCA cis rs8141529 1.000 rs132534 chr22:29299806 T/C cg15103426 chr22:29168792 CCDC117 -0.5 -11.15 -0.4 1.6e-26 Lymphocyte counts; BRCA cis rs12579753 0.956 rs11115038 chr12:82214660 T/G cg07988820 chr12:82153109 PPFIA2 -0.67 -10.7 -0.39 1.13e-24 Resting heart rate; BRCA cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 26.38 0.72 2.76e-104 Chronic sinus infection; BRCA cis rs12950390 0.853 rs8071192 chr17:45856141 A/G cg03474202 chr17:45855739 NA -0.48 -12.65 -0.45 6.85e-33 IgG glycosylation; BRCA cis rs6714710 0.603 rs35255677 chr2:98567820 G/A cg26665480 chr2:98280029 ACTR1B 0.59 13.62 0.47 2.91e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA trans rs11098499 0.863 rs2306457 chr4:120472839 T/A cg25214090 chr10:38739885 LOC399744 0.53 11.69 0.42 9.28e-29 Corneal astigmatism; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg21747090 chr2:27597821 SNX17 -0.37 -7.89 -0.3 1.33e-14 Total body bone mineral density; BRCA cis rs6951245 0.572 rs79489623 chr7:1045632 C/T cg18402987 chr7:1209562 NA 0.87 9.15 0.34 7.77e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10791323 0.569 rs2282602 chr11:133714522 G/A cg14349672 chr11:133703707 NA -0.41 -9.13 -0.34 9.09e-19 Childhood ear infection; BRCA cis rs9660992 0.674 rs1151784 chr1:205232447 C/T cg21545522 chr1:205238299 TMCC2 0.4 8.36 0.31 3.85e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg06627628 chr2:24431161 ITSN2 -0.54 -8.84 -0.33 9.14e-18 Lymphocyte counts; BRCA cis rs35146811 0.660 rs6465760 chr7:99591418 A/G cg22906224 chr7:99728672 NA -0.44 -8.5 -0.32 1.29e-16 Coronary artery disease; BRCA cis rs4664304 0.620 rs2357691 chr2:160725139 A/G cg14819504 chr2:160761413 LY75 -0.34 -8.26 -0.31 8.61e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs3925075 0.934 rs9673522 chr16:31347648 T/C cg02846316 chr16:31340340 ITGAM 0.54 13.29 0.47 9.24e-36 IgA nephropathy; BRCA trans rs1459104 0.636 rs559362 chr11:55275456 T/G cg03929089 chr4:120376271 NA 0.52 8.07 0.3 3.4e-15 Body mass index; BRCA cis rs2576037 0.507 rs2571019 chr18:44585287 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.51 -11.55 -0.42 3.88e-28 Personality dimensions; BRCA trans rs2204008 0.604 rs11172718 chr12:38069819 T/C cg06521331 chr12:34319734 NA -0.54 -10.31 -0.38 3.61e-23 Bladder cancer; BRCA cis rs425277 0.628 rs262662 chr1:2085033 A/G cg24578937 chr1:2090814 PRKCZ 0.38 11.78 0.42 4.16e-29 Height; BRCA cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg18305652 chr10:134549665 INPP5A 0.51 13.12 0.46 5.49e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg06766960 chr11:133703094 NA -0.61 -13.29 -0.47 9.15e-36 Childhood ear infection; BRCA cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg16482183 chr6:26056742 HIST1H1C 0.51 10.75 0.39 7.03e-25 Height; BRCA cis rs12220238 1.000 rs10824090 chr10:75923446 C/T cg19889307 chr10:75911429 ADK;AP3M1 0.48 7.94 0.3 8.87e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs6088580 0.634 rs6059824 chr20:33014543 T/C cg08999081 chr20:33150536 PIGU 0.44 12.26 0.44 3.36e-31 Glomerular filtration rate (creatinine); BRCA trans rs11039798 1.000 rs11039798 chr11:48540223 G/A cg15704280 chr7:45808275 SEPT13 0.69 8.18 0.31 1.56e-15 Axial length; BRCA cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg08355456 chr11:67383691 NA -0.4 -8.71 -0.33 2.51e-17 Mean corpuscular volume; BRCA cis rs7267979 0.966 rs2261698 chr20:25259910 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.78 0.36 3.95e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8028182 0.636 rs4886715 chr15:75831449 C/T cg20655648 chr15:75932815 IMP3 0.42 8.26 0.31 8.3e-16 Sudden cardiac arrest; BRCA cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.63 15.06 0.51 4.14e-44 Chronic sinus infection; BRCA cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.22e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs3820928 0.934 rs4675117 chr2:227769794 A/G cg11843606 chr2:227700838 RHBDD1 0.41 8.19 0.31 1.44e-15 Pulmonary function; BRCA cis rs1555322 0.530 rs2425042 chr20:33865895 G/A cg17927777 chr20:33865990 NA 0.47 8.75 0.33 1.88e-17 Attention deficit hyperactivity disorder; BRCA cis rs611744 0.625 rs6469168 chr8:109288399 G/T cg21045802 chr8:109455806 TTC35 0.39 9.04 0.34 1.84e-18 Dupuytren's disease; BRCA cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg05890377 chr2:74357713 NA -0.42 -9.26 -0.34 3.12e-19 Gestational age at birth (maternal effect); BRCA cis rs8180040 0.966 rs57346147 chr3:47410564 C/G cg16586182 chr3:47516702 SCAP 0.64 14.83 0.51 5.65e-43 Colorectal cancer; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -13.52 -0.47 8.46e-37 Bipolar disorder and schizophrenia; BRCA cis rs7617773 0.851 rs6775179 chr3:48313418 T/C cg11946769 chr3:48343235 NME6 0.62 13.51 0.47 9.11e-37 Coronary artery disease; BRCA cis rs2075371 0.796 rs1646644 chr7:134011817 A/T cg02659138 chr7:134003124 SLC35B4 0.33 10.41 0.38 1.46e-23 Mean platelet volume; BRCA cis rs9325144 0.560 rs10876005 chr12:39126149 C/G cg26384229 chr12:38710491 ALG10B -0.49 -12.02 -0.43 3.64e-30 Morning vs. evening chronotype; BRCA cis rs7528419 1.000 rs629301 chr1:109818306 G/T cg00908766 chr1:109817496 CELSR2 0.62 19.41 0.61 2.54e-66 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Myocardial infarction;Lipoprotein-associated phospholipase A2 activity and mass;Lipoprotein-associated phospholipase A2 activity change in response to darapladib treatment in cardiovascular disease;Cholesterol, total;Coronary artery disease; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg07092213 chr7:1199455 ZFAND2A -0.57 -12.78 -0.45 1.8e-33 Longevity;Endometriosis; BRCA cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg11764359 chr7:65958608 NA 0.76 16.82 0.55 7.85e-53 Aortic root size; BRCA cis rs9296092 0.538 rs62407564 chr6:33534010 C/T cg13560919 chr6:33536144 NA -0.91 -19.42 -0.61 2.12e-66 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg16339924 chr4:17578868 LAP3 0.57 13.96 0.48 7.43e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs9291683 0.632 rs13101785 chr4:10042915 T/A cg02734326 chr4:10020555 SLC2A9 0.38 8.22 0.31 1.17e-15 Bone mineral density; BRCA cis rs2415984 0.622 rs61993294 chr14:46932466 C/G cg14871534 chr14:47121158 RPL10L -0.38 -9.04 -0.34 1.84e-18 Number of children ever born; BRCA cis rs7011049 0.908 rs72640860 chr8:53840500 G/A cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs9399135 0.967 rs13218642 chr6:135309940 A/G cg24558204 chr6:135376177 HBS1L 0.47 12.77 0.45 2.04e-33 Red blood cell count; BRCA cis rs6582630 0.555 rs56228141 chr12:38518652 T/G cg13010199 chr12:38710504 ALG10B 0.52 10.87 0.4 2.24e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs1568889 1.000 rs7949057 chr11:28255053 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.67 0.5 3.17e-42 Bipolar disorder; BRCA cis rs12477438 0.798 rs10196680 chr2:99628617 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs6840258 0.941 rs7665282 chr4:87900850 C/T cg08197287 chr4:87952173 AFF1 -0.44 -8.28 -0.31 7.47e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg08807101 chr21:30365312 RNF160 -0.57 -13.87 -0.48 1.98e-38 Dental caries; BRCA cis rs698813 0.573 rs6544750 chr2:44490780 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 8.62 0.32 5.46e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 10.95 0.4 1.04e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg16414030 chr3:133502952 NA 0.4 8.98 0.33 2.94e-18 Iron status biomarkers; BRCA cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs6740322 0.895 rs10196095 chr2:43571885 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.09 -0.43 1.9e-30 Coronary artery disease; BRCA cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs9815354 0.812 rs56983571 chr3:41994473 T/C cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg14863265 chr7:2801509 GNA12 -0.46 -10.08 -0.37 2.91e-22 Height; BRCA trans rs11250098 0.567 rs4326350 chr8:10763655 C/G cg06636001 chr8:8085503 FLJ10661 0.43 8.74 0.33 2.03e-17 Morning vs. evening chronotype; BRCA cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg01689657 chr7:91764605 CYP51A1 0.21 7.86 0.3 1.61e-14 Breast cancer; BRCA cis rs6541297 1.000 rs6658942 chr1:230287517 A/C cg20703242 chr1:230279135 GALNT2 0.47 10.36 0.38 2.4e-23 Coronary artery disease; BRCA cis rs875971 0.928 rs6970357 chr7:65968878 T/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA trans rs11098499 0.865 rs9994730 chr4:120381564 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.13 0.31 2.28e-15 Corneal astigmatism; BRCA cis rs758324 0.947 rs4705838 chr5:131150593 G/T cg06307176 chr5:131281290 NA 0.54 10.32 0.38 3.37e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs739401 1.000 rs739401 chr11:3036324 C/T cg25174290 chr11:3078921 CARS -0.38 -11.23 -0.41 8.15e-27 Longevity; BRCA cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg11764359 chr7:65958608 NA 0.63 14.3 0.49 1.81e-40 Aortic root size; BRCA cis rs9649465 0.561 rs2429620 chr7:123430012 A/G cg03229431 chr7:123269106 ASB15 0.41 9.48 0.35 5.1e-20 Migraine; BRCA trans rs8002861 0.810 rs7334812 chr13:44445538 C/T cg17145862 chr1:211918768 LPGAT1 0.65 16.59 0.55 1.19e-51 Leprosy; BRCA cis rs6964587 0.869 rs10276682 chr7:91486070 G/A cg17063962 chr7:91808500 NA -0.54 -12.92 -0.46 4.26e-34 Breast cancer; BRCA cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg03517284 chr6:25882590 NA -0.36 -8.42 -0.32 2.42e-16 Height; BRCA cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs10504073 0.647 rs6997703 chr8:49998364 T/C cg00325661 chr8:49890786 NA 0.44 12.44 0.44 5.56e-32 Blood metabolite ratios; BRCA cis rs875971 0.545 rs801212 chr7:66015630 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -9.67 -0.36 1.01e-20 Aortic root size; BRCA cis rs546131 0.928 rs552868 chr11:34830694 G/A cg11058730 chr11:34937778 PDHX;APIP 0.45 8.41 0.32 2.62e-16 Lung disease severity in cystic fibrosis; BRCA cis rs2204008 0.774 rs7304438 chr12:38361146 T/G cg13010199 chr12:38710504 ALG10B 0.51 10.46 0.38 9.29e-24 Bladder cancer; BRCA cis rs2115536 0.730 rs12898642 chr15:80182050 T/C cg02196730 chr15:80188777 MTHFS 0.38 8.62 0.32 5.44e-17 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs7927771 0.832 rs10838697 chr11:47384484 T/A cg20307385 chr11:47447363 PSMC3 -0.42 -8.76 -0.33 1.72e-17 Subjective well-being; BRCA cis rs12425451 0.544 rs28623776 chr12:3147631 C/T cg05389053 chr12:3131226 TEAD4 -0.44 -8.35 -0.31 4.21e-16 Narcolepsy with cataplexy; BRCA cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg20701182 chr2:24300061 SF3B14 0.56 8.61 0.32 5.89e-17 Lymphocyte counts; BRCA cis rs425277 0.606 rs451061 chr1:2075068 C/G cg19257562 chr1:2043853 PRKCZ -0.34 -9.65 -0.36 1.17e-20 Height; BRCA cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg01849466 chr14:104193079 ZFYVE21 0.41 10.46 0.38 9.34e-24 Schizophrenia; BRCA cis rs9814567 1.000 rs6439484 chr3:134249899 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs853679 0.607 rs67998226 chr6:28238059 T/C cg06606381 chr12:133084897 FBRSL1 -0.82 -8.76 -0.33 1.75e-17 Depression; BRCA cis rs17253792 0.908 rs9972177 chr14:56073206 G/A cg01858014 chr14:56050164 KTN1 -0.78 -10.8 -0.39 4.21e-25 Putamen volume; BRCA cis rs131777 0.708 rs131749 chr22:51024624 C/T cg05418105 chr22:50981406 NA 0.43 8.36 0.31 3.9e-16 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs514406 0.708 rs480299 chr1:53320274 G/T cg25767906 chr1:53392781 SCP2 -0.49 -10.67 -0.39 1.42e-24 Monocyte count; BRCA cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.55 11.2 0.41 1.05e-26 Multiple sclerosis; BRCA cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg26031613 chr14:104095156 KLC1 0.53 10.47 0.38 9.02e-24 Schizophrenia; BRCA cis rs514406 0.929 rs557715 chr1:53321593 C/G cg08859206 chr1:53392774 SCP2 -0.51 -11.13 -0.4 2.08e-26 Monocyte count; BRCA cis rs2120019 1.000 rs7173833 chr15:75369618 C/T cg06070324 chr15:75322058 PPCDC 0.39 8.14 0.31 2.12e-15 Blood trace element (Zn levels); BRCA trans rs459571 0.920 rs460154 chr9:136909309 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.69 -13.76 -0.48 6.14e-38 Platelet distribution width; BRCA cis rs868036 1.000 rs3784719 chr15:68098180 C/T cg08079166 chr15:68083412 MAP2K5 0.35 9.44 0.35 7.13e-20 Restless legs syndrome; BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg00149659 chr3:10157352 C3orf10 0.8 13.73 0.48 9.11e-38 Alzheimer's disease; BRCA cis rs7945705 0.846 rs11042055 chr11:8756856 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.52 10.79 0.39 4.56e-25 Hemoglobin concentration; BRCA trans rs526821 0.574 rs11230156 chr11:55334809 A/G cg15704280 chr7:45808275 SEPT13 -0.42 -7.98 -0.3 7.04e-15 Pediatric bone mineral density (spine); BRCA trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg15704280 chr7:45808275 SEPT13 -0.7 -14.08 -0.49 2.08e-39 Coronary artery disease; BRCA cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs2832191 0.935 rs11910475 chr21:30519702 T/C cg24692254 chr21:30365293 RNF160 -0.59 -14.83 -0.51 5.77e-43 Dental caries; BRCA cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg20203395 chr5:56204925 C5orf35 0.41 9.18 0.34 5.91e-19 Initial pursuit acceleration; BRCA cis rs1113500 0.933 rs10785834 chr1:108639101 A/C cg06207961 chr1:108661230 NA 0.44 10.79 0.39 4.68e-25 Growth-regulated protein alpha levels; BRCA cis rs10484885 0.680 rs72921943 chr6:90581542 A/C cg13799429 chr6:90582589 CASP8AP2 -0.88 -17.0 -0.56 9.97e-54 QRS interval (sulfonylurea treatment interaction); BRCA cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg11822812 chr5:140052017 DND1 -0.3 -8.31 -0.31 5.89e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs67981189 0.896 rs7146591 chr14:71438228 C/T cg15816911 chr14:71606274 NA -0.36 -8.03 -0.3 4.81e-15 Schizophrenia; BRCA cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg21385522 chr1:16154831 NA 0.47 8.45 0.32 1.9e-16 Dilated cardiomyopathy; BRCA cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg03146154 chr1:46216737 IPP -0.44 -9.64 -0.36 1.27e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs965469 0.895 rs6037595 chr20:3401128 T/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.05 -0.37 3.59e-22 IFN-related cytopenia; BRCA trans rs7618501 0.521 rs34654589 chr3:49911449 C/G cg21659725 chr3:3221576 CRBN 0.36 8.5 0.32 1.33e-16 Intelligence (multi-trait analysis); BRCA cis rs1153858 1.000 rs4774578 chr15:45646051 G/A cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Homoarginine levels; BRCA cis rs921968 0.541 rs3770216 chr2:219443717 A/G cg10223061 chr2:219282414 VIL1 0.3 8.69 0.33 3.04e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs1707322 1.000 rs6677777 chr1:46475836 A/G cg03146154 chr1:46216737 IPP 0.49 10.62 0.39 2.29e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg11707556 chr5:10655725 ANKRD33B 0.4 8.87 0.33 7.33e-18 Coronary artery disease; BRCA cis rs6942756 0.806 rs6967464 chr7:128909727 T/C cg02491457 chr7:128862824 NA 0.57 12.0 0.43 4.73e-30 White matter hyperintensity burden; BRCA cis rs9402673 0.517 rs978036 chr6:135342903 C/T cg24558204 chr6:135376177 HBS1L 0.44 12.2 0.43 6.19e-31 Reticulocyte count;High light scatter reticulocyte count; BRCA cis rs782590 0.559 rs12617719 chr2:55915826 G/C cg18811423 chr2:55921094 PNPT1 -0.64 -19.11 -0.6 9.57e-65 Metabolic syndrome; BRCA cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg26248373 chr2:1572462 NA -0.67 -15.88 -0.53 4e-48 IgG glycosylation; BRCA cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14416726 chr6:151773293 C6orf211;RMND1 -0.35 -8.32 -0.31 5.4e-16 Menarche (age at onset); BRCA cis rs36051895 0.695 rs7043489 chr9:5023604 A/C cg02405213 chr9:5042618 JAK2 -0.44 -8.23 -0.31 1.09e-15 Pediatric autoimmune diseases; BRCA cis rs10911251 0.528 rs4652779 chr1:183104552 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.52 0.55 2.47e-51 Colorectal cancer; BRCA cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg11764359 chr7:65958608 NA -0.63 -11.16 -0.4 1.5e-26 Aortic root size; BRCA cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg21782813 chr7:2030301 MAD1L1 0.39 10.22 0.37 8.22e-23 Bipolar disorder and schizophrenia; BRCA cis rs1788820 0.917 rs1652349 chr18:21142734 A/T cg14672496 chr18:21087552 C18orf8 0.34 8.19 0.31 1.43e-15 Body mass index; BRCA cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg20487152 chr13:99095054 FARP1 -0.4 -11.67 -0.42 1.2e-28 Neuroticism; BRCA trans rs7200543 0.961 rs3803573 chr16:15138413 C/T cg24683922 chr1:11983373 KIAA2013 -0.35 -7.83 -0.3 2e-14 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs6598955 0.671 rs11247896 chr1:26600483 A/G cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg06238570 chr21:40685208 BRWD1 -0.4 -8.06 -0.3 3.77e-15 Menarche (age at onset); BRCA cis rs13046373 0.535 rs35909098 chr21:32021649 C/T cg24082983 chr21:31802169 KRTAP13-4 0.33 8.33 0.31 5.05e-16 HDL cholesterol; BRCA cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg21573476 chr21:45109991 RRP1B -0.42 -11.25 -0.41 6.46e-27 Mean corpuscular volume; BRCA cis rs10929956 0.760 rs2729704 chr2:160707866 T/A cg01092293 chr2:160761427 LY75 -0.36 -8.52 -0.32 1.12e-16 Crohn's disease-related phenotypes; BRCA cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg12386194 chr3:101231763 SENP7 0.46 9.66 0.36 1.05e-20 Colorectal cancer; BRCA trans rs208520 0.507 rs9453585 chr6:66796668 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -38.27 -0.83 1.82e-167 Exhaled nitric oxide output; BRCA cis rs9814567 1.000 rs1814336 chr3:134200823 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.89 -0.33 6.18e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4466137 0.953 rs7735476 chr5:83015140 G/C cg16102102 chr5:83017553 HAPLN1 -0.92 -18.52 -0.59 1.23e-61 Prostate cancer; BRCA cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg13319975 chr6:146136371 FBXO30 -0.36 -8.16 -0.31 1.73e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 1.000 rs9864346 chr3:134312352 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -9.32 -0.35 1.88e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg24846343 chr22:24311635 DDTL 0.57 15.01 0.51 7.46e-44 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4908760 0.931 rs1463049 chr1:8597108 A/T cg20416874 chr1:8611966 RERE -0.28 -8.1 -0.31 2.86e-15 Vitiligo; BRCA cis rs10089 1.000 rs4835944 chr5:127490870 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.65 -14.24 -0.49 3.5e-40 Ileal carcinoids; BRCA cis rs2985684 0.841 rs12894785 chr14:50049755 G/C cg04989706 chr14:50066350 PPIL5 -0.47 -9.26 -0.34 3.13e-19 Carotid intima media thickness; BRCA cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg03452623 chr4:187889614 NA -0.32 -10.71 -0.39 1.04e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg00701064 chr4:6280414 WFS1 0.67 17.55 0.57 1.46e-56 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg01262667 chr19:19385393 TM6SF2 0.42 10.88 0.4 2.04e-25 Tonsillectomy; BRCA cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg11644478 chr21:40555479 PSMG1 -0.46 -9.91 -0.37 1.2e-21 Cognitive function; BRCA cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg18230493 chr5:56204884 C5orf35 -0.72 -14.07 -0.49 2.27e-39 Initial pursuit acceleration; BRCA cis rs2835872 0.733 rs2850124 chr21:39036763 T/A cg06728970 chr21:39037746 KCNJ6 0.43 12.38 0.44 1.1e-31 Electroencephalographic traits in alcoholism; BRCA cis rs9527 0.615 rs10883781 chr10:104581130 A/G cg04362960 chr10:104952993 NT5C2 0.44 9.27 0.34 2.92e-19 Arsenic metabolism; BRCA cis rs6570726 0.791 rs1280275 chr6:145892402 C/T cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs495337 0.760 rs6122845 chr20:48546274 G/A cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs703842 0.616 rs4760171 chr12:58225904 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.46 8.5 0.32 1.35e-16 Multiple sclerosis; BRCA cis rs365132 0.875 rs4490607 chr5:176349386 T/C cg16309518 chr5:176445507 NA -0.39 -9.61 -0.36 1.59e-20 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7772486 0.902 rs2144476 chr6:146322484 G/A cg23711669 chr6:146136114 FBXO30 0.63 14.42 0.5 4.94e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs9290065 0.519 rs2121721 chr3:160685788 A/G cg03342759 chr3:160939853 NMD3 -0.46 -9.36 -0.35 1.38e-19 Kawasaki disease; BRCA cis rs13118159 0.801 rs1128427 chr4:1330759 T/C cg05025164 chr4:1340916 KIAA1530 0.4 8.97 0.33 3.39e-18 Longevity; BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg05863683 chr7:1912471 MAD1L1 -0.35 -8.41 -0.32 2.65e-16 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg11833968 chr6:79620685 NA -0.41 -9.05 -0.34 1.78e-18 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.693 rs2838344 chr21:45089877 C/T cg21573476 chr21:45109991 RRP1B -0.4 -10.68 -0.39 1.32e-24 Mean corpuscular volume; BRCA cis rs2806561 0.704 rs2746560 chr1:23526279 G/A cg12483005 chr1:23474871 LUZP1 0.48 10.46 0.38 9.57e-24 Height; BRCA cis rs10927875 0.541 rs1739843 chr1:16343254 T/C cg06159980 chr1:16340746 HSPB7 -0.38 -8.83 -0.33 1.01e-17 Dilated cardiomyopathy; BRCA cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg13126279 chr21:47581558 C21orf56 -0.38 -8.27 -0.31 7.59e-16 Testicular germ cell tumor; BRCA cis rs7927771 1.000 rs12418852 chr11:47868853 C/G cg18512352 chr11:47633146 NA -0.35 -8.37 -0.31 3.64e-16 Subjective well-being; BRCA cis rs2742234 0.541 rs11238483 chr10:43728780 A/G cg15436174 chr10:43711423 RASGEF1A 0.53 10.62 0.39 2.29e-24 Hirschsprung disease; BRCA cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -10.16 -0.37 1.35e-22 Bone mineral density; BRCA cis rs17641971 0.684 rs11990854 chr8:49992048 T/C cg00325661 chr8:49890786 NA 0.39 10.81 0.39 4.14e-25 Blood metabolite levels; BRCA cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg12310025 chr6:25882481 NA -0.56 -12.34 -0.44 1.55e-31 Intelligence (multi-trait analysis); BRCA cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg08085267 chr17:45401833 C17orf57 0.63 12.98 0.46 2.39e-34 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg24324837 chr19:49891574 CCDC155 0.42 7.86 0.3 1.68e-14 Multiple sclerosis; BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.71e-14 Tonsillectomy; BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.54 -0.32 1.01e-16 Total body bone mineral density; BRCA cis rs9463078 0.764 rs9369516 chr6:44833598 C/T cg25276700 chr6:44698697 NA -0.36 -8.31 -0.31 5.82e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs8180040 0.620 rs7373821 chr3:47080127 A/C cg27129171 chr3:47204927 SETD2 0.71 16.99 0.56 1.03e-53 Colorectal cancer; BRCA cis rs1401999 0.899 rs2313211 chr3:183738626 T/A cg20387954 chr3:183756860 HTR3D 0.47 10.45 0.38 1.01e-23 Anterior chamber depth; BRCA cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs6500602 0.701 rs4785971 chr16:4577090 A/G cg08645402 chr16:4508243 NA 0.43 9.95 0.37 8.82e-22 Schizophrenia; BRCA cis rs56104184 0.830 rs45589039 chr19:49355385 C/T cg15549821 chr19:49342101 PLEKHA4 -1.05 -15.64 -0.53 6.17e-47 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.96 26.43 0.72 1.42e-104 Birth weight; BRCA cis rs10248839 0.518 rs1317741 chr7:29711149 T/C cg19413766 chr7:29689036 LOC646762 -0.56 -8.92 -0.33 4.87e-18 Facial emotion recognition (angry faces); BRCA cis rs9467773 1.000 rs9467797 chr6:26568473 A/T cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.8e-21 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg08888203 chr3:10149979 C3orf24 0.65 13.64 0.47 2.35e-37 Alzheimer's disease; BRCA cis rs34330 0.562 rs7486387 chr12:12866911 G/A cg09462578 chr12:12878428 APOLD1 -0.58 -10.4 -0.38 1.66e-23 Systemic lupus erythematosus; BRCA cis rs758324 0.783 rs253941 chr5:131320293 C/T cg06307176 chr5:131281290 NA -0.52 -10.41 -0.38 1.44e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs637571 0.544 rs12361552 chr11:65701204 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.45 -9.35 -0.35 1.4e-19 Eosinophil percentage of white cells; BRCA trans rs6952808 0.692 rs56727870 chr7:2029940 T/C cg04565464 chr8:145669602 NFKBIL2 0.38 8.93 0.33 4.59e-18 Bipolar disorder and schizophrenia; BRCA cis rs3820928 0.839 rs4675123 chr2:227800205 T/C cg11843606 chr2:227700838 RHBDD1 -0.39 -8.6 -0.32 6.39e-17 Pulmonary function; BRCA trans rs12517041 1.000 rs28472703 chr5:23281381 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs7267979 1.000 rs2258719 chr20:25275843 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.33 8.73 0.33 2.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17376456 0.825 rs12716453 chr5:93271697 T/C cg25358565 chr5:93447407 FAM172A 1.16 18.42 0.59 4.3e-61 Diabetic retinopathy; BRCA cis rs35849525 0.814 rs7635601 chr3:50044006 A/T cg14019146 chr3:50243930 SLC38A3 -0.55 -11.37 -0.41 2.14e-27 Intelligence (multi-trait analysis); BRCA cis rs11676348 0.755 rs1008562 chr2:219026972 G/C cg20019365 chr2:219134978 PNKD;AAMP 0.45 9.42 0.35 7.78e-20 Ulcerative colitis; BRCA cis rs60843830 0.508 rs300750 chr2:208794 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.42 8.27 0.31 7.62e-16 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg04025307 chr7:1156635 C7orf50 0.59 9.31 0.35 2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11690935 0.959 rs7562356 chr2:172626611 C/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.74 -0.77 4.42e-128 Schizophrenia; BRCA cis rs877282 0.945 rs11253391 chr10:788752 G/A cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg04511125 chr2:88470314 THNSL2 -0.52 -10.77 -0.39 5.85e-25 Response to metformin (IC50); BRCA cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.12e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7408868 1.000 rs8107180 chr19:15275430 T/C cg14696996 chr19:15285081 NOTCH3 0.99 14.46 0.5 3.39e-41 Pulse pressure; BRCA cis rs523522 0.962 rs509445 chr12:121017243 A/C cg12219531 chr12:120966889 COQ5 0.53 11.14 0.4 1.81e-26 High light scatter reticulocyte count; BRCA cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg19628046 chr18:33552617 C18orf21 0.6 12.38 0.44 1.01e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg22920501 chr2:26401640 FAM59B -0.66 -11.52 -0.41 4.74e-28 Gut microbiome composition (summer); BRCA cis rs7582180 0.568 rs10186134 chr2:100939501 T/A cg14675211 chr2:100938903 LONRF2 0.42 9.4 0.35 9.93e-20 Intelligence (multi-trait analysis); BRCA cis rs6500602 0.963 rs7201012 chr16:4480682 C/G cg08645402 chr16:4508243 NA 0.37 8.86 0.33 7.67e-18 Schizophrenia; BRCA cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg17366294 chr4:99064904 C4orf37 0.5 11.06 0.4 3.81e-26 Colonoscopy-negative controls vs population controls; BRCA trans rs10028773 0.666 rs12498657 chr4:120262866 G/C cg25214090 chr10:38739885 LOC399744 0.42 9.76 0.36 4.41e-21 Educational attainment; BRCA cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg06484146 chr7:12443880 VWDE -0.66 -10.22 -0.37 8.22e-23 Coronary artery disease; BRCA cis rs9469578 0.892 rs6929527 chr6:33707976 G/T cg18708504 chr6:33715942 IP6K3 0.72 10.42 0.38 1.43e-23 Phosphorus levels; BRCA cis rs9815354 0.812 rs73081321 chr3:41890231 G/A cg03022575 chr3:42003672 ULK4 0.71 9.71 0.36 7.25e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg24399712 chr22:39784796 NA -0.58 -13.74 -0.48 8.09e-38 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs9309711 0.643 rs4264589 chr2:3481098 G/T cg08493051 chr2:3487164 NA -0.43 -9.1 -0.34 1.09e-18 Neurofibrillary tangles; BRCA cis rs9527 0.615 rs10883811 chr10:104727279 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.64 0.39 1.87e-24 Arsenic metabolism; BRCA cis rs317689 0.876 rs547332 chr12:69743639 C/G cg14784868 chr12:69753453 YEATS4 0.51 11.52 0.41 4.96e-28 Response to diuretic therapy; BRCA cis rs6545883 0.718 rs3771260 chr2:61762384 G/T cg15711740 chr2:61764176 XPO1 -0.54 -13.87 -0.48 1.93e-38 Tuberculosis; BRCA cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg10011062 chr15:43941034 CATSPER2 -0.52 -7.83 -0.3 2.1e-14 Lung cancer in ever smokers; BRCA cis rs3925075 0.515 rs4459557 chr16:31361643 G/C cg02846316 chr16:31340340 ITGAM 0.43 9.39 0.35 1.01e-19 IgA nephropathy; BRCA cis rs9549367 0.577 rs3024718 chr13:113813853 C/T cg00898013 chr13:113819073 PROZ 0.45 10.22 0.37 8.21e-23 Platelet distribution width; BRCA cis rs7493 1.000 rs17876123 chr7:95045307 C/A cg17330251 chr7:94953956 PON1 -0.42 -8.58 -0.32 7.32e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10267417 0.603 rs10260797 chr7:19890181 A/G cg05791153 chr7:19748676 TWISTNB 0.47 9.14 0.34 7.94e-19 Night sleep phenotypes; BRCA cis rs875971 0.862 rs10256544 chr7:65675128 A/G cg11764359 chr7:65958608 NA 0.76 17.1 0.56 2.94e-54 Aortic root size; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg16425592 chr11:842748 TSPAN4;POLR2L -0.64 -14.92 -0.51 2.13e-43 Mean platelet volume; BRCA trans rs61931739 0.890 rs814663 chr12:34106338 C/T cg26384229 chr12:38710491 ALG10B 0.44 10.35 0.38 2.51e-23 Morning vs. evening chronotype; BRCA cis rs17270561 0.636 rs1165157 chr6:25792250 A/G cg16482183 chr6:26056742 HIST1H1C 0.41 8.78 0.33 1.49e-17 Iron status biomarkers; BRCA cis rs78456975 0.527 rs72778003 chr2:1571487 G/A cg01028140 chr2:1542097 TPO -0.61 -12.61 -0.45 9.79e-33 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7312933 0.567 rs11181399 chr12:42666412 G/A cg01256987 chr12:42539512 GXYLT1 -0.42 -8.49 -0.32 1.49e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs826838 0.935 rs1486357 chr12:39073675 A/G cg26384229 chr12:38710491 ALG10B 0.82 21.86 0.65 1.51e-79 Heart rate; BRCA cis rs6867032 0.958 rs4505990 chr5:2015811 A/G cg26168224 chr5:2018326 NA 0.64 17.71 0.57 2.02e-57 Gut microbiome composition (winter); BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.68 -13.76 -0.48 6.61e-38 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.97 0.43 6.48e-30 Corneal astigmatism; BRCA cis rs9443645 0.901 rs1567167 chr6:79553827 C/T cg18132916 chr6:79620363 NA -0.46 -10.66 -0.39 1.57e-24 Intelligence (multi-trait analysis); BRCA cis rs1712517 0.740 rs11191663 chr10:105118462 C/T cg05636881 chr10:105038444 INA 0.36 7.96 0.3 7.99e-15 Migraine; BRCA cis rs597539 0.617 rs686348 chr11:68636996 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.63 0.55 7.04e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.49 0.41 6.87e-28 Height; BRCA cis rs9815354 1.000 rs9874513 chr3:41909508 G/A cg03022575 chr3:42003672 ULK4 0.51 8.31 0.31 5.54e-16 Pulse pressure;Diastolic blood pressure; BRCA cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg00339695 chr16:24857497 SLC5A11 0.36 8.5 0.32 1.38e-16 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.42 -0.35 7.95e-20 Alzheimer's disease; BRCA cis rs881375 0.678 rs10985102 chr9:123707497 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.63 0.42 1.71e-28 Rheumatoid arthritis; BRCA cis rs6813479 0.562 rs2634900 chr4:137733596 C/A cg16185213 chr4:137733633 NA 0.39 9.13 0.34 9.07e-19 Longevity; BRCA trans rs7618501 0.516 rs2856236 chr3:50161717 A/C cg21659725 chr3:3221576 CRBN -0.43 -10.38 -0.38 1.93e-23 Intelligence (multi-trait analysis); BRCA cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs10504229 0.683 rs6980850 chr8:58127204 A/G cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs68170813 0.641 rs77397573 chr7:107006892 G/A cg02696742 chr7:106810147 HBP1 -0.55 -8.61 -0.32 5.89e-17 Coronary artery disease; BRCA cis rs6598955 0.671 rs11247880 chr1:26568926 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -8.09 -0.3 3.11e-15 Obesity-related traits; BRCA cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg02734326 chr4:10020555 SLC2A9 0.39 8.28 0.31 7.31e-16 Bone mineral density; BRCA trans rs1814175 0.654 rs1164676 chr11:49324868 T/C cg15704280 chr7:45808275 SEPT13 0.74 17.82 0.58 6.03e-58 Height; BRCA cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg05535760 chr7:792225 HEATR2 -0.74 -11.7 -0.42 8.3e-29 Cerebrospinal P-tau181p levels; BRCA cis rs9287719 0.810 rs1990612 chr2:10781944 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.91 -0.3 1.13e-14 Prostate cancer; BRCA cis rs10046574 0.561 rs10214966 chr7:135196642 A/G cg27474649 chr7:135195673 CNOT4 0.67 10.95 0.4 1.07e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.46 0.32 1.76e-16 Menopause (age at onset); BRCA cis rs8062405 0.929 rs11150609 chr16:28870596 A/G cg16576597 chr16:28551801 NUPR1 0.29 8.21 0.31 1.2e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7772486 0.790 rs4075694 chr6:146251108 G/C cg13319975 chr6:146136371 FBXO30 0.41 9.3 0.35 2.13e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.541 rs9379207 chr6:8458186 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg23173402 chr1:227635558 NA 0.51 9.3 0.35 2.21e-19 Major depressive disorder; BRCA trans rs11098499 0.954 rs6846442 chr4:120326323 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs3733585 0.699 rs6449172 chr4:9966036 A/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.53 -0.38 4.99e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1949733 0.523 rs16842560 chr4:8544238 G/A cg11789530 chr4:8429930 ACOX3 -0.55 -12.51 -0.44 2.96e-32 Response to antineoplastic agents; BRCA cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg22105103 chr4:187893119 NA 0.38 11.86 0.42 1.75e-29 Lobe attachment (rater-scored or self-reported); BRCA trans rs629535 0.862 rs654604 chr8:70048939 C/A cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs2762353 0.935 rs1177442 chr6:25809069 A/G cg12310025 chr6:25882481 NA -0.51 -12.16 -0.43 9.04e-31 Blood metabolite levels; BRCA cis rs6977660 0.660 rs61670426 chr7:19790460 A/G cg07541023 chr7:19748670 TWISTNB 0.58 9.87 0.36 1.71e-21 Thyroid stimulating hormone; BRCA cis rs4889855 0.530 rs12603265 chr17:78618637 A/G cg16591659 chr17:78472290 NA -0.32 -8.26 -0.31 8.41e-16 Fractional excretion of uric acid; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.57 -10.36 -0.38 2.38e-23 Renal function-related traits (BUN); BRCA trans rs8062405 1.000 rs62036620 chr16:28833097 A/G cg09719594 chr16:21412588 NA -0.32 -7.82 -0.3 2.19e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg01475377 chr6:109611718 NA 0.59 16.33 0.54 2.24e-50 Reticulocyte fraction of red cells; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.77 -13.56 -0.47 5.25e-37 Gut microbiome composition (summer); BRCA cis rs1008375 0.932 rs4698628 chr4:17608620 A/G cg16339924 chr4:17578868 LAP3 0.62 15.45 0.52 5.68e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8016982 0.651 rs9806027 chr14:81668707 G/C cg01989461 chr14:81687754 GTF2A1 0.61 14.3 0.49 1.99e-40 Schizophrenia; BRCA cis rs8072100 1.000 rs4375701 chr17:45712218 C/T cg25173405 chr17:45401733 C17orf57 -0.52 -11.17 -0.4 1.33e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9287719 0.614 rs10929681 chr2:10723283 C/T cg00105475 chr2:10696890 NA 0.41 9.17 0.34 6.17e-19 Prostate cancer; BRCA cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg26944245 chr16:421049 TMEM8A;MRPL28 0.46 9.03 0.34 2.07e-18 Bone mineral density (spine);Bone mineral density; BRCA cis rs17641971 0.684 rs11785391 chr8:49930203 G/T cg00325661 chr8:49890786 NA 0.39 10.64 0.39 1.89e-24 Blood metabolite levels; BRCA cis rs992157 0.798 rs12053514 chr2:219167965 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.34 -0.41 2.79e-27 Colorectal cancer; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.58 0.55 1.26e-51 Gut microbiome composition (summer); BRCA cis rs1005277 0.505 rs7099777 chr10:38183569 A/C cg25427524 chr10:38739819 LOC399744 0.66 16.08 0.54 4.08e-49 Extrinsic epigenetic age acceleration; BRCA cis rs73001065 0.818 rs73004975 chr19:19727152 A/G cg03709012 chr19:19516395 GATAD2A 0.77 9.61 0.36 1.64e-20 LDL cholesterol; BRCA cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg24642439 chr20:33292090 TP53INP2 -0.54 -11.76 -0.42 4.75e-29 Glomerular filtration rate (creatinine); BRCA cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg13010199 chr12:38710504 ALG10B 0.58 12.72 0.45 3.48e-33 Heart rate; BRCA cis rs6684514 1.000 rs2241106 chr1:156218910 C/G cg16558208 chr1:156270281 VHLL 0.36 7.94 0.3 9.43e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs4713118 0.513 rs1225591 chr6:28148752 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.85 0.33 8.53e-18 Parkinson's disease; BRCA cis rs10464366 0.746 rs6945547 chr7:39145389 C/G cg18850127 chr7:39170497 POU6F2 0.49 10.83 0.39 3.36e-25 IgG glycosylation; BRCA cis rs6121246 0.512 rs6060938 chr20:30363645 T/C cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs6547741 0.752 rs7562863 chr2:27892694 T/A cg27432699 chr2:27873401 GPN1 -0.5 -10.51 -0.38 6.25e-24 Oral cavity cancer; BRCA trans rs6582630 0.519 rs1607868 chr12:38385512 G/T cg06521331 chr12:34319734 NA -0.45 -8.34 -0.31 4.46e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs2637266 0.935 rs2579720 chr10:78399918 T/C cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs12681288 0.712 rs2600488 chr8:1021266 A/C cg04851639 chr8:1020857 NA -0.34 -10.07 -0.37 3.08e-22 Schizophrenia; BRCA trans rs877282 0.838 rs11253408 chr10:796374 T/C cg22713356 chr15:30763199 NA 1.41 28.52 0.75 5.26e-116 Uric acid levels; BRCA cis rs11190604 1.000 rs3793706 chr10:102269085 A/C cg07080220 chr10:102295463 HIF1AN -0.59 -14.16 -0.49 8.25e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1707322 0.721 rs11211181 chr1:46236800 C/T cg06784218 chr1:46089804 CCDC17 0.46 10.89 0.4 1.93e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2832077 0.527 rs9981922 chr21:30212718 A/G cg08807101 chr21:30365312 RNF160 -0.55 -12.57 -0.45 1.55e-32 Cognitive test performance; BRCA cis rs936229 0.749 rs7497201 chr15:75190690 A/G cg10253484 chr15:75165896 SCAMP2 -0.6 -11.56 -0.42 3.3e-28 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.59 0.32 6.61e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72792276 1.000 rs56657382 chr5:127387338 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.54 9.41 0.35 8.67e-20 Red cell distribution width; BRCA cis rs4919087 1.000 rs12221430 chr10:99061386 C/G cg25902810 chr10:99078978 FRAT1 0.5 10.83 0.39 3.3e-25 Monocyte count; BRCA cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg24562669 chr7:97807699 LMTK2 0.62 18.43 0.59 3.57e-61 Breast cancer; BRCA cis rs950776 1.000 rs950776 chr15:78926018 A/G cg06917634 chr15:78832804 PSMA4 0.6 11.71 0.42 8.24e-29 Sudden cardiac arrest; BRCA cis rs1048238 0.506 rs10927866 chr1:16175317 C/T cg21385522 chr1:16154831 NA 0.48 10.29 0.38 4.37e-23 Systolic blood pressure; BRCA cis rs4891159 0.790 rs7234653 chr18:74111988 C/T cg24786174 chr18:74118243 ZNF516 -0.74 -18.41 -0.59 4.58e-61 Longevity; BRCA cis rs6684514 1.000 rs12027103 chr1:156244856 G/A cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg05347473 chr6:146136440 FBXO30 0.42 8.06 0.3 3.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA trans rs11039798 0.858 rs7121333 chr11:48332138 C/T cg15704280 chr7:45808275 SEPT13 0.54 8.19 0.31 1.43e-15 Axial length; BRCA cis rs9287719 0.967 rs12995159 chr2:10753323 C/T cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg14004847 chr7:1930337 MAD1L1 0.46 10.02 0.37 4.71e-22 Bipolar disorder and schizophrenia; BRCA cis rs9790314 0.846 rs7627528 chr3:160990878 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -10.21 -0.37 8.85e-23 Morning vs. evening chronotype; BRCA cis rs4481887 1.000 rs6697735 chr1:248465315 G/C cg00666640 chr1:248458726 OR2T12 0.32 8.59 0.32 6.44e-17 Common traits (Other); BRCA cis rs4478858 0.839 rs10798834 chr1:31708977 G/A cg00250761 chr1:31883323 NA -0.32 -8.48 -0.32 1.59e-16 Alcohol dependence; BRCA cis rs7267979 1.000 rs6083856 chr20:25407585 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.64 -0.32 4.63e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg05283184 chr6:79620031 NA -0.42 -11.06 -0.4 3.85e-26 Intelligence (multi-trait analysis); BRCA cis rs875971 1.000 rs1167612 chr7:65567976 C/A cg12463550 chr7:65579703 CRCP -0.37 -7.82 -0.3 2.19e-14 Aortic root size; BRCA cis rs941873 0.868 rs12780295 chr10:81115438 G/A cg08514558 chr10:81106712 PPIF 0.35 8.46 0.32 1.86e-16 Height; BRCA cis rs11051970 0.877 rs2651360 chr12:32588920 C/T cg02745156 chr12:32552066 NA 0.27 8.89 0.33 6.07e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6066835 1.000 rs6066820 chr20:47318444 T/C cg18078177 chr20:47281410 PREX1 0.69 8.21 0.31 1.25e-15 Multiple myeloma; BRCA trans rs911555 0.755 rs4906329 chr14:103942669 A/G cg17675199 chr6:35436792 RPL10A -0.29 -7.82 -0.3 2.26e-14 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.898 rs72786276 chr2:24062566 G/A cg20701182 chr2:24300061 SF3B14 0.68 9.84 0.36 2.37e-21 Lymphocyte counts; BRCA cis rs11792861 0.926 rs58795279 chr9:111851902 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.09 0.3 3.1e-15 Menarche (age at onset); BRCA cis rs11051970 0.877 rs2728671 chr12:32589715 T/A cg02745156 chr12:32552066 NA 0.27 8.87 0.33 7.25e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs881375 0.669 rs73541868 chr9:123639264 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.56 0.32 8.44e-17 Rheumatoid arthritis; BRCA cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg13770153 chr20:60521292 NA -0.46 -10.99 -0.4 7.66e-26 Body mass index; BRCA cis rs1113500 0.787 rs10881501 chr1:108641745 C/T cg06207961 chr1:108661230 NA 0.36 9.05 0.34 1.78e-18 Growth-regulated protein alpha levels; BRCA cis rs72781680 0.611 rs72797818 chr2:24351107 G/A cg06627628 chr2:24431161 ITSN2 -0.56 -8.87 -0.33 7.52e-18 Lymphocyte counts; BRCA cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg20503657 chr10:835505 NA 1.05 18.42 0.59 4.49e-61 Eosinophil percentage of granulocytes; BRCA trans rs6089829 0.962 rs2872543 chr20:61665017 G/A cg23505145 chr19:12996616 KLF1 0.56 12.76 0.45 2.12e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg15017067 chr4:17643749 FAM184B 0.35 10.99 0.4 7.64e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg05623727 chr3:50126028 RBM5 -0.42 -10.02 -0.37 4.73e-22 Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 25.18 0.71 9.98e-98 Platelet count; BRCA cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg05874882 chr4:1763078 NA 0.47 8.44 0.32 2.16e-16 Bladder cancer;Urinary bladder cancer; BRCA cis rs6545883 0.929 rs12713436 chr2:61691260 T/C cg15711740 chr2:61764176 XPO1 -0.56 -14.29 -0.49 2.03e-40 Tuberculosis; BRCA cis rs6598955 0.671 rs12086573 chr1:26574330 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs765787 0.530 rs28414644 chr15:45536721 G/C cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.37e-15 Uric acid levels; BRCA cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg16586182 chr3:47516702 SCAP -0.43 -8.62 -0.32 5.18e-17 Birth weight; BRCA cis rs7091068 0.518 rs1543580 chr10:95446811 C/T cg20715218 chr10:95462985 C10orf4 0.47 9.94 0.37 9.77e-22 Urinary tract infection frequency; BRCA trans rs4332037 0.802 rs12113633 chr7:1932936 G/A cg11693508 chr17:37793320 STARD3 0.67 12.21 0.43 5.71e-31 Bipolar disorder; BRCA cis rs8038465 0.592 rs1542580 chr15:73935834 C/G cg15420318 chr15:73925796 NPTN 0.42 9.33 0.35 1.65e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2645694 0.626 rs2645684 chr4:77819892 A/C cg10057126 chr4:77819792 ANKRD56 0.67 15.27 0.52 4.03e-45 Emphysema distribution in smoking; BRCA cis rs10504229 0.683 rs2318148 chr8:58114955 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.07 -0.34 1.5e-18 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 18.11 0.58 1.82e-59 Platelet count; BRCA cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg24450063 chr1:156163899 SLC25A44 0.92 17.94 0.58 1.34e-58 Testicular germ cell tumor; BRCA cis rs977987 0.806 rs11865004 chr16:75395777 C/T cg03315344 chr16:75512273 CHST6 0.53 12.57 0.45 1.61e-32 Dupuytren's disease; BRCA cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg08085267 chr17:45401833 C17orf57 -0.5 -9.57 -0.35 2.2e-20 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12541635 0.701 rs2029878 chr8:107025283 A/G cg10147462 chr8:107024639 NA 0.37 9.85 0.36 2.13e-21 Age of smoking initiation; BRCA cis rs4853036 0.629 rs13428251 chr2:70014561 G/C cg02498382 chr2:70120550 SNRNP27 -0.43 -8.03 -0.3 4.87e-15 Colorectal or endometrial cancer; BRCA trans rs7615952 0.551 rs6438945 chr3:125634473 G/A cg07211511 chr3:129823064 LOC729375 -1.05 -18.4 -0.59 5.22e-61 Blood pressure (smoking interaction); BRCA cis rs9399135 0.935 rs4445070 chr6:135309212 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.48 0.44 3.7e-32 Red blood cell count; BRCA cis rs2290405 0.527 rs4690329 chr4:931385 T/A cg04824913 chr4:887549 GAK 0.71 12.93 0.46 3.76e-34 Systemic sclerosis; BRCA cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg04166393 chr7:2884313 GNA12 0.4 8.57 0.32 7.85e-17 Height; BRCA trans rs7647973 0.626 rs1352889 chr3:49652148 T/C cg21659725 chr3:3221576 CRBN -0.47 -8.66 -0.32 3.84e-17 Menarche (age at onset); BRCA trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg23505145 chr19:12996616 KLF1 0.54 12.36 0.44 1.31e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs1975991 0.597 rs9863463 chr3:187955779 T/G cg15417654 chr3:187959138 LPP 0.36 9.23 0.34 4.01e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs6138458 1.000 rs7269416 chr20:24976196 T/G cg26195577 chr20:24973756 C20orf3 1.03 28.97 0.75 1.65e-118 Blood protein levels; BRCA cis rs3733585 0.699 rs6839490 chr4:9965000 C/G cg11266682 chr4:10021025 SLC2A9 0.34 8.62 0.32 5.35e-17 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs501916 0.761 rs79925748 chr15:48046412 G/C cg16110827 chr15:48056943 SEMA6D -0.39 -8.25 -0.31 9.27e-16 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs881375 0.967 rs1548783 chr9:123658639 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.48 9.77 0.36 4e-21 Rheumatoid arthritis; BRCA cis rs11098499 0.954 rs10008459 chr4:120394231 T/C cg09307838 chr4:120376055 NA 0.75 16.14 0.54 2.07e-49 Corneal astigmatism; BRCA cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg17143192 chr8:8559678 CLDN23 0.49 9.45 0.35 6.1e-20 Obesity-related traits; BRCA cis rs2836974 0.965 rs2836965 chr21:40633631 C/G cg11890956 chr21:40555474 PSMG1 -1.03 -28.54 -0.75 3.91e-116 Cognitive function; BRCA cis rs4925386 0.840 rs8124907 chr20:60913127 A/G cg24112000 chr20:60950667 NA -0.47 -9.26 -0.34 3.11e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg12311346 chr5:56204834 C5orf35 0.62 12.95 0.46 3.14e-34 Initial pursuit acceleration; BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg13628971 chr7:2884303 GNA12 0.47 9.57 0.35 2.32e-20 Height; BRCA cis rs870825 0.929 rs72689273 chr4:185592750 C/T cg04058563 chr4:185651563 MLF1IP 0.68 11.6 0.42 2.33e-28 Blood protein levels; BRCA cis rs7586879 0.765 rs10171663 chr2:25086431 T/C cg04586622 chr2:25135609 ADCY3 0.37 8.94 0.33 4.26e-18 Body mass index; BRCA cis rs9815354 0.812 rs17218504 chr3:41987278 A/G cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs6547741 1.000 rs11127071 chr2:27838058 C/A cg27432699 chr2:27873401 GPN1 0.44 9.31 0.35 2.04e-19 Oral cavity cancer; BRCA cis rs10752881 1.000 rs12028740 chr1:182985581 G/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.17e-52 Colorectal cancer; BRCA cis rs3806843 1.000 rs2098058 chr5:140157427 A/C cg16179182 chr5:140090404 VTRNA1-1 0.41 9.31 0.35 1.95e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs2276314 0.947 rs16967319 chr18:33573525 A/G cg19628046 chr18:33552617 C18orf21 0.58 11.53 0.42 4.47e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1878931 0.507 rs11648783 chr16:3406626 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.45 7.92 0.3 1.02e-14 Body mass index (adult); BRCA cis rs6088590 1.000 rs6058111 chr20:33310999 T/C cg06115741 chr20:33292138 TP53INP2 0.49 11.02 0.4 5.73e-26 Coronary artery disease; BRCA cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs1005277 0.579 rs1740747 chr10:38520465 G/A cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.61e-27 Extrinsic epigenetic age acceleration; BRCA cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg01802117 chr1:53393560 SCP2 -0.36 -8.31 -0.31 5.97e-16 Monocyte count; BRCA cis rs2204008 0.522 rs117743143 chr12:38030824 C/T cg13010199 chr12:38710504 ALG10B 0.4 8.56 0.32 8.67e-17 Bladder cancer; BRCA cis rs769267 1.000 rs769267 chr19:19446936 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.38 8.96 0.33 3.46e-18 Tonsillectomy; BRCA trans rs62103177 0.810 rs62103194 chr18:77629482 G/A cg05926928 chr17:57297772 GDPD1 1.21 15.95 0.53 1.8e-48 Opioid sensitivity; BRCA cis rs10751667 0.666 rs7123912 chr11:963936 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.62 0.55 8.25e-52 Alzheimer's disease (late onset); BRCA cis rs7647973 1.000 rs3870339 chr3:49536863 T/A cg07636037 chr3:49044803 WDR6 0.75 16.49 0.55 3.8e-51 Menarche (age at onset); BRCA cis rs4690686 0.500 rs7683662 chr4:177272004 A/T cg17059388 chr4:177262070 NA 0.54 11.33 0.41 2.94e-27 Essential tremor; BRCA cis rs7412746 0.658 rs4970982 chr1:150865084 G/C cg15448220 chr1:150897856 SETDB1 0.35 7.88 0.3 1.38e-14 Melanoma; BRCA cis rs68170813 0.521 rs61673847 chr7:106892431 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.33 -0.31 4.77e-16 Coronary artery disease; BRCA trans rs6951245 0.554 rs4724294 chr7:1139695 G/A cg13565492 chr6:43139072 SRF -0.89 -16.16 -0.54 1.65e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7254827 0.522 rs1077795 chr19:17222584 A/G cg19418318 chr19:17219073 MYO9B -0.39 -8.92 -0.33 4.98e-18 Mean platelet volume; BRCA cis rs2070488 0.574 rs57754356 chr3:38488706 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.12 0.56 2.3e-54 Electrocardiographic conduction measures; BRCA cis rs708547 0.874 rs7674167 chr4:57721477 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.46 -10.41 -0.38 1.54e-23 Response to bleomycin (chromatid breaks); BRCA cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7927771 0.524 rs7932703 chr11:47769936 A/C cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs72781680 0.821 rs72781644 chr2:24209348 T/C cg08917208 chr2:24149416 ATAD2B 0.61 10.44 0.38 1.16e-23 Lymphocyte counts; BRCA cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg08807892 chr2:162101083 NA -0.48 -9.73 -0.36 5.93e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs2832191 0.729 rs2832201 chr21:30499841 A/G cg24692254 chr21:30365293 RNF160 -0.72 -19.08 -0.6 1.43e-64 Dental caries; BRCA trans rs4714291 0.722 rs9296320 chr6:40118298 C/G cg02267698 chr19:7991119 CTXN1 0.43 8.99 0.34 2.77e-18 Strep throat; BRCA cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg24920358 chr1:40204285 PPIE 0.34 7.93 0.3 9.95e-15 Blood protein levels; BRCA cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg23029597 chr12:123009494 RSRC2 -0.59 -11.38 -0.41 1.9e-27 Body mass index; BRCA cis rs7945705 0.818 rs4929916 chr11:8824996 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.49 10.76 0.39 6.31e-25 Hemoglobin concentration; BRCA cis rs7809950 0.954 rs2520241 chr7:107135443 A/G cg23024343 chr7:107201750 COG5 -0.42 -9.6 -0.36 1.77e-20 Coronary artery disease; BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg10729496 chr3:10149963 C3orf24 0.49 9.01 0.34 2.35e-18 Alzheimer's disease; BRCA cis rs7772486 0.754 rs9390356 chr6:146118983 A/T cg05347473 chr6:146136440 FBXO30 -0.45 -8.89 -0.33 6.29e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg04025307 chr7:1156635 C7orf50 0.51 9.86 0.36 1.96e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs754466 0.651 rs2004382 chr10:79650351 G/C cg17075019 chr10:79541650 NA -0.71 -16.21 -0.54 9.51e-50 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg22764044 chr5:178986830 RUFY1 0.44 10.88 0.4 2e-25 Lung cancer; BRCA cis rs7267979 1.000 rs6083825 chr20:25366424 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4363385 0.782 rs394859 chr1:153025704 T/C cg24667326 chr1:152973720 SPRR3 -0.31 -8.27 -0.31 7.56e-16 Inflammatory skin disease; BRCA cis rs7613875 0.543 rs34034116 chr3:49959156 C/A cg24110177 chr3:50126178 RBM5 -0.51 -14.45 -0.5 3.53e-41 Body mass index; BRCA cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg15595755 chr5:1867978 NA 0.37 8.67 0.32 3.5e-17 Cardiovascular disease risk factors; BRCA cis rs9283706 0.608 rs10065036 chr5:66338084 G/A cg11590213 chr5:66331682 MAST4 0.37 7.88 0.3 1.4e-14 Coronary artery disease; BRCA cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg03161606 chr19:29218774 NA 0.46 8.11 0.31 2.56e-15 Methadone dose in opioid dependence; BRCA cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg08508325 chr11:3079039 CARS -0.41 -14.33 -0.49 1.42e-40 Longevity; BRCA cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.95 0.6 7.28e-64 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4466137 0.830 rs6886695 chr5:82994293 T/A cg16102102 chr5:83017553 HAPLN1 -0.92 -17.63 -0.57 5.25e-57 Prostate cancer; BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg08470875 chr2:26401718 FAM59B 0.58 9.17 0.34 6.58e-19 Gut microbiome composition (summer); BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.66 10.75 0.39 6.91e-25 Renal function-related traits (BUN); BRCA cis rs6066825 0.555 rs4810849 chr20:47289944 C/T cg18078177 chr20:47281410 PREX1 0.4 10.04 0.37 4.18e-22 Colorectal cancer; BRCA cis rs1371614 0.632 rs6759548 chr2:27161060 A/G cg00617064 chr2:27272375 NA -0.3 -8.1 -0.31 2.8e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs9858542 0.903 rs35999162 chr3:49597230 C/G cg21659725 chr3:3221576 CRBN -0.46 -9.85 -0.36 2.17e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs870825 0.616 rs2130393 chr4:185642335 T/C cg04058563 chr4:185651563 MLF1IP 0.76 16.78 0.55 1.26e-52 Blood protein levels; BRCA cis rs921968 0.509 rs832813 chr2:219354569 T/C cg10223061 chr2:219282414 VIL1 -0.26 -7.81 -0.3 2.38e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs832540 0.695 rs702686 chr5:56201350 A/G cg24549020 chr5:56110836 MAP3K1 0.38 8.15 0.31 1.94e-15 Coronary artery disease; BRCA cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg01579765 chr21:45077557 HSF2BP -0.43 -11.47 -0.41 8e-28 Mean corpuscular volume; BRCA cis rs2742234 0.504 rs7093409 chr10:43740067 A/G cg15436174 chr10:43711423 RASGEF1A 0.5 10.08 0.37 2.95e-22 Hirschsprung disease; BRCA cis rs2046867 0.818 rs62249860 chr3:72866073 T/G cg25664220 chr3:72788482 NA -0.55 -11.73 -0.42 6.4e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs12200560 0.505 rs1334318 chr6:97079610 A/G cg06623918 chr6:96969491 KIAA0776 -0.46 -10.61 -0.39 2.51e-24 Coronary heart disease; BRCA cis rs765787 0.530 rs4775819 chr15:45525966 C/T cg15395560 chr15:45543142 SLC28A2 0.3 8.45 0.32 2.02e-16 Uric acid levels; BRCA cis rs2540552 0.600 rs35432547 chr7:91200238 G/A cg15143024 chr7:91199642 NA -0.47 -11.77 -0.42 4.28e-29 IgG glycosylation; BRCA cis rs7666738 0.830 rs7659006 chr4:98934529 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1800795 0.599 rs1546762 chr7:22757503 C/T cg05472934 chr7:22766657 IL6 0.42 10.54 0.38 4.6e-24 Cerebrospinal fluid clusterin levels in APOEe4- carriers; BRCA cis rs1150668 0.796 rs9468372 chr6:28379361 T/A cg00651523 chr6:28411279 ZSCAN23 -0.36 -7.82 -0.3 2.21e-14 Pubertal anthropometrics; BRCA cis rs10911251 0.508 rs10797854 chr1:183106739 G/A ch.1.3577855R chr1:183094577 LAMC1 0.62 15.93 0.53 2.21e-48 Colorectal cancer; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg03188948 chr7:1209495 NA 0.63 12.83 0.45 1.05e-33 Longevity;Endometriosis; BRCA cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg24642439 chr20:33292090 TP53INP2 0.42 8.45 0.32 2.03e-16 Height; BRCA cis rs1577917 0.958 rs11758508 chr6:86506878 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.48 12.77 0.45 1.97e-33 Response to antipsychotic treatment; BRCA cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg15556689 chr8:8085844 FLJ10661 -0.36 -8.16 -0.31 1.72e-15 Obesity-related traits; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg08888203 chr3:10149979 C3orf24 0.65 11.96 0.43 6.86e-30 Alzheimer's disease; BRCA cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg01689657 chr7:91764605 CYP51A1 0.24 8.48 0.32 1.59e-16 Breast cancer; BRCA cis rs7267979 0.932 rs446649 chr20:25467359 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.29 8.0 0.3 5.7e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg11644478 chr21:40555479 PSMG1 -0.68 -15.3 -0.52 3e-45 Cognitive function; BRCA cis rs11098499 0.821 rs10032151 chr4:120391628 C/T cg09307838 chr4:120376055 NA 0.76 16.36 0.54 1.61e-50 Corneal astigmatism; BRCA cis rs7127900 0.583 rs11043140 chr11:2233951 T/C cg25635251 chr11:2234043 NA 0.46 12.55 0.44 1.97e-32 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); BRCA cis rs7613875 0.578 rs2526749 chr3:50076734 A/G cg24110177 chr3:50126178 RBM5 0.52 15.68 0.53 4e-47 Body mass index; BRCA cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg17845761 chr1:175162550 KIAA0040 -0.25 -9.66 -0.36 1.05e-20 Alcohol dependence; BRCA cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg10523679 chr1:76189770 ACADM 0.76 15.51 0.52 2.79e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10465746 0.935 rs12758441 chr1:84352034 A/G cg10977910 chr1:84465055 TTLL7 0.51 10.31 0.38 3.81e-23 Obesity-related traits; BRCA trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg15704280 chr7:45808275 SEPT13 -0.55 -10.6 -0.39 2.7e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs1801251 1.000 rs36007169 chr2:233621834 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.42 0.41 1.28e-27 Coronary artery disease; BRCA cis rs7772486 0.875 rs9376975 chr6:146355581 T/G cg23711669 chr6:146136114 FBXO30 0.73 17.14 0.56 1.74e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6750047 0.585 rs62136319 chr2:38272950 G/A cg07380506 chr2:38303506 CYP1B1 0.48 10.54 0.38 4.65e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7191700 0.578 rs243324 chr16:11354970 A/G cg00044050 chr16:11439710 C16orf75 0.38 8.99 0.34 2.79e-18 Multiple sclerosis; BRCA cis rs7020830 0.898 rs6476617 chr9:37200103 G/A cg14294708 chr9:37120828 ZCCHC7 1.09 34.18 0.8 2.16e-146 Schizophrenia; BRCA cis rs2795502 1.000 rs2795503 chr10:43347224 T/A cg20628663 chr10:43360327 NA -0.71 -13.74 -0.48 8.06e-38 Blood protein levels; BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs7249142 0.562 rs10418053 chr19:19287164 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.42 -8.84 -0.33 9.55e-18 IgG glycosylation; BRCA cis rs73001065 0.901 rs739846 chr19:19419071 G/A cg03709012 chr19:19516395 GATAD2A 0.8 9.42 0.35 7.76e-20 LDL cholesterol; BRCA cis rs12142240 0.698 rs72677585 chr1:46812374 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs6701037 0.512 rs2285216 chr1:175133012 C/T cg00321850 chr1:175162397 KIAA0040 0.44 12.39 0.44 9.15e-32 Alcohol dependence; BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg06627628 chr2:24431161 ITSN2 -0.57 -9.12 -0.34 9.96e-19 Lymphocyte counts; BRCA trans rs1005277 0.522 rs9417256 chr10:37976990 A/G cg17830980 chr10:43048298 ZNF37B -0.42 -9.77 -0.36 4.32e-21 Extrinsic epigenetic age acceleration; BRCA cis rs887829 0.570 rs45615240 chr2:234599296 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.34 -0.31 4.62e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs10206020 0.921 rs72776302 chr2:1571383 G/A cg01028140 chr2:1542097 TPO -0.58 -11.82 -0.42 2.77e-29 IgG glycosylation; BRCA cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -7.9 -0.3 1.18e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7178424 1.000 rs4775458 chr15:62375036 T/G cg00456672 chr15:62358751 C2CD4A -0.35 -8.3 -0.31 6.42e-16 Height; BRCA cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.62 12.86 0.45 7.88e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.8 0.33 1.25e-17 Platelet count; BRCA cis rs6138458 1.000 rs227658 chr20:24932028 A/G cg06937882 chr20:24974362 C20orf3 -0.47 -8.97 -0.33 3.28e-18 Blood protein levels; BRCA cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg18132916 chr6:79620363 NA -0.48 -10.91 -0.4 1.59e-25 Intelligence (multi-trait analysis); BRCA cis rs6062302 0.545 rs2297430 chr20:62229244 T/C cg16989086 chr20:62203971 PRIC285 0.52 8.74 0.33 2.05e-17 Glioblastoma; BRCA cis rs9443645 0.527 rs1413968 chr6:79791042 A/G cg09184832 chr6:79620586 NA -0.44 -8.83 -0.33 9.68e-18 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.962 rs9679865 chr20:61666132 C/G cg03213289 chr20:61660250 NA 0.61 16.2 0.54 1e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs7577696 0.597 rs212690 chr2:32437631 C/G cg02381751 chr2:32503542 YIPF4 0.48 8.74 0.33 2.08e-17 Inflammatory biomarkers; BRCA cis rs875971 1.000 rs2220626 chr7:65546062 C/T cg18876405 chr7:65276391 NA -0.57 -13.21 -0.46 2.12e-35 Aortic root size; BRCA cis rs10911232 0.507 rs4072709 chr1:183028855 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.23e-51 Hypertriglyceridemia; BRCA cis rs6089584 0.507 rs28545731 chr20:60634102 C/T cg06108461 chr20:60628389 TAF4 -0.74 -15.13 -0.51 1.93e-44 Body mass index; BRCA cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg05340658 chr4:99064831 C4orf37 0.68 17.08 0.56 3.57e-54 Colonoscopy-negative controls vs population controls; BRCA trans rs9409565 0.762 rs55877910 chr9:97234213 G/C cg05679027 chr9:99775184 HIATL2 -0.43 -9.4 -0.35 9.79e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05901451 chr6:126070800 HEY2 0.4 9.79 0.36 3.51e-21 Endometrial cancer; BRCA cis rs877282 0.685 rs56234340 chr10:781339 A/G cg17470449 chr10:769945 NA 0.43 7.91 0.3 1.1e-14 Uric acid levels; BRCA cis rs12579753 0.833 rs12579530 chr12:82163930 A/C cg07988820 chr12:82153109 PPFIA2 -0.64 -11.34 -0.41 2.7e-27 Resting heart rate; BRCA cis rs11696845 0.649 rs6031782 chr20:43383832 A/G cg25301532 chr20:43378953 KCNK15 -0.43 -10.26 -0.38 5.8e-23 Obesity-related traits; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg21143896 chr7:2802374 GNA12 -0.34 -8.64 -0.32 4.34e-17 Height; BRCA cis rs2243480 1.000 rs13220979 chr7:65363204 G/A cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -14.51 -0.5 1.97e-41 Initial pursuit acceleration; BRCA cis rs6088590 0.735 rs6060001 chr20:33294353 C/T cg24642439 chr20:33292090 TP53INP2 -0.53 -11.4 -0.41 1.59e-27 Coronary artery disease; BRCA cis rs7618915 0.508 rs7628578 chr3:52628321 A/T cg10802521 chr3:52805072 NEK4 -0.33 -8.92 -0.33 4.95e-18 Bipolar disorder; BRCA cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg00031303 chr3:195681400 NA -0.48 -8.99 -0.33 2.85e-18 Pancreatic cancer; BRCA cis rs9486719 1.000 rs12190397 chr6:97036465 G/A cg06623918 chr6:96969491 KIAA0776 -0.76 -13.44 -0.47 1.88e-36 Migraine;Coronary artery disease; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.7 0.33 2.75e-17 Platelet count; BRCA cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg08917208 chr2:24149416 ATAD2B 0.93 13.77 0.48 5.51e-38 Lymphocyte counts; BRCA cis rs13046373 0.535 rs8129571 chr21:31980646 G/A cg22337977 chr21:31811175 KRTAP15-1 0.35 8.31 0.31 5.68e-16 HDL cholesterol; BRCA trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg11887960 chr12:57824829 NA 0.55 8.57 0.32 7.74e-17 Lung disease severity in cystic fibrosis; BRCA cis rs7809950 0.954 rs12673675 chr7:107113220 T/C cg23024343 chr7:107201750 COG5 -0.42 -9.63 -0.36 1.32e-20 Coronary artery disease; BRCA cis rs34172651 0.917 rs35283675 chr16:24820393 A/G cg00152838 chr16:24741724 TNRC6A -0.35 -7.82 -0.3 2.16e-14 Intelligence (multi-trait analysis); BRCA cis rs17685 0.697 rs2302437 chr7:75677016 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.4 8.97 0.33 3.13e-18 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg15934090 chr1:100435551 SLC35A3 0.35 8.11 0.31 2.66e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs11809207 0.523 rs2783626 chr1:26501044 C/T cg00147160 chr1:26503991 CNKSR1 -0.28 -9.22 -0.34 4.1e-19 Height; BRCA cis rs933688 1.000 rs9293568 chr5:90737845 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.15 0.62 2.72e-70 Smoking behavior; BRCA trans rs61931739 0.500 rs3924704 chr12:34557833 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.67 0.36 9.78e-21 Morning vs. evening chronotype; BRCA cis rs12497850 0.864 rs4279134 chr3:49156676 A/G cg06212747 chr3:49208901 KLHDC8B 0.51 10.51 0.38 6.26e-24 Parkinson's disease; BRCA cis rs56399783 0.901 rs17300022 chr7:2808517 C/T cg19731401 chr7:2775893 GNA12 -0.54 -8.67 -0.32 3.68e-17 Childhood ear infection; BRCA cis rs769267 0.965 rs4808937 chr19:19398005 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.57 0.39 3.41e-24 Tonsillectomy; BRCA cis rs1401999 0.546 rs56889301 chr3:183675315 T/C cg01324343 chr3:183735012 ABCC5 0.7 17.12 0.56 2.33e-54 Anterior chamber depth; BRCA cis rs6547741 0.967 rs4665996 chr2:27814343 T/C cg27432699 chr2:27873401 GPN1 0.46 9.71 0.36 6.83e-21 Oral cavity cancer; BRCA trans rs2204008 0.536 rs12368354 chr12:38042798 G/A cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.55e-21 Bladder cancer; BRCA cis rs6700896 0.931 rs10443261 chr1:66129121 T/C cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9682041 0.696 rs6774380 chr3:170091644 T/A cg11886554 chr3:170076028 SKIL 0.51 10.24 0.38 7.03e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg20887711 chr4:1340912 KIAA1530 0.72 15.68 0.53 4.26e-47 Longevity; BRCA cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg20908204 chr19:46285434 DMPK -0.28 -8.29 -0.31 6.63e-16 Coronary artery disease; BRCA cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg23583168 chr7:148888333 NA -0.86 -20.1 -0.62 5.34e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.21e-18 Tonsillectomy; BRCA cis rs12950390 0.853 rs11658511 chr17:45856918 T/C cg06532163 chr17:45867833 NA 0.39 7.94 0.3 9.3e-15 IgG glycosylation; BRCA cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.49 10.87 0.39 2.35e-25 IgG glycosylation; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg22907277 chr7:1156413 C7orf50 0.6 11.51 0.41 5.69e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7267979 1.000 rs6050559 chr20:25329915 A/G cg08601574 chr20:25228251 PYGB 0.36 8.79 0.33 1.35e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg18765753 chr7:1198926 ZFAND2A -0.37 -8.86 -0.33 8.05e-18 Longevity;Endometriosis; BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.22 0.34 4.12e-19 Tonsillectomy; BRCA cis rs274567 0.599 rs11242110 chr5:131743777 A/C cg07395648 chr5:131743802 NA 0.56 14.98 0.51 1.07e-43 Blood metabolite levels; BRCA cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg12863693 chr15:85201151 NMB 0.56 11.91 0.43 1.16e-29 Schizophrenia; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg13047869 chr3:10149882 C3orf24 -0.59 -12.51 -0.44 2.94e-32 Alzheimer's disease; BRCA cis rs599083 0.530 rs546803 chr11:68186392 C/T cg01657329 chr11:68192670 LRP5 0.36 7.86 0.3 1.61e-14 Bone mineral density (spine); BRCA cis rs55665837 1.000 rs12288873 chr11:14450465 C/T cg19336497 chr11:14380999 RRAS2 -0.36 -9.47 -0.35 5.22e-20 Vitamin D levels; BRCA cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.4 -0.61 2.69e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6964587 1.000 rs415 chr7:91580490 A/G cg01689657 chr7:91764605 CYP51A1 -0.22 -7.87 -0.3 1.57e-14 Breast cancer; BRCA cis rs965469 1.000 rs6139068 chr20:3284393 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -10.55 -0.39 4.29e-24 IFN-related cytopenia; BRCA cis rs7666738 0.830 rs62321570 chr4:98984276 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg08999081 chr20:33150536 PIGU 0.5 14.04 0.49 3.21e-39 Coronary artery disease; BRCA cis rs2832191 1.000 rs2832189 chr21:30487414 C/T cg24692254 chr21:30365293 RNF160 -0.6 -15.15 -0.51 1.56e-44 Dental caries; BRCA cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg07741184 chr6:167504864 NA 0.26 7.81 0.3 2.35e-14 Crohn's disease; BRCA cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg09035930 chr12:129282057 SLC15A4 0.55 16.19 0.54 1.17e-49 Systemic lupus erythematosus; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs12545109 0.765 rs1960726 chr8:57411733 T/C cg09654669 chr8:57350985 NA -0.38 -8.34 -0.31 4.55e-16 Obesity-related traits; BRCA cis rs7408868 0.908 rs62113794 chr19:15277337 C/A cg14696996 chr19:15285081 NOTCH3 1.02 14.48 0.5 2.56e-41 Pulse pressure; BRCA cis rs6893300 0.524 rs10516146 chr5:179166974 A/G cg14593053 chr5:179126677 CANX 0.49 13.42 0.47 2.3e-36 Resting heart rate; BRCA cis rs9814567 0.964 rs6776203 chr3:134234345 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.81 -0.33 1.22e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9325144 0.624 rs7312879 chr12:39150752 G/A cg26384229 chr12:38710491 ALG10B -0.5 -11.29 -0.41 4.54e-27 Morning vs. evening chronotype; BRCA cis rs243505 0.762 rs2007404 chr7:148487395 A/G cg09806900 chr7:148480153 CUL1 0.52 11.17 0.4 1.36e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4819052 0.851 rs8126930 chr21:46671715 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.53 11.68 0.42 1.1e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.45 8.48 0.32 1.59e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7772486 0.875 rs2777482 chr6:146320341 A/C cg23711669 chr6:146136114 FBXO30 0.59 12.88 0.45 6.27e-34 Lobe attachment (rater-scored or self-reported); BRCA cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg14343924 chr8:8086146 FLJ10661 0.43 7.98 0.3 6.82e-15 Red cell distribution width; BRCA cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg26408565 chr15:76604113 ETFA -0.46 -9.82 -0.36 2.74e-21 Blood metabolite levels; BRCA cis rs11758351 1.000 rs3734530 chr6:26195408 G/C cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs198389 0.589 rs198391 chr1:11876417 C/T cg24844545 chr1:11908347 NPPA 0.33 8.76 0.33 1.78e-17 B-type natriuretic peptide levels;NT-proBNP levels in acute coronary syndrome; BRCA cis rs6088590 0.561 rs6059926 chr20:33164804 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.74 0.33 1.99e-17 Coronary artery disease; BRCA cis rs9467773 0.620 rs2504600 chr6:26648334 C/A cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.02e-42 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg25036284 chr2:26402008 FAM59B 0.83 11.73 0.42 6.48e-29 Gut microbiome composition (summer); BRCA cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -14.01 -0.48 4.46e-39 Cognitive function; BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg16606324 chr3:10149918 C3orf24 0.58 11.5 0.41 6.09e-28 Alzheimer's disease; BRCA cis rs11920090 0.858 rs16855591 chr3:170693708 A/G cg09710316 chr3:170744871 SLC2A2 0.51 8.06 0.3 3.75e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs2629540 0.882 rs10901813 chr10:126429875 G/A cg08799069 chr10:126477246 METTL10 -0.53 -11.34 -0.41 2.78e-27 Cocaine dependence; BRCA cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.07 0.3 3.59e-15 Diabetic retinopathy; BRCA cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg18132916 chr6:79620363 NA -0.48 -10.76 -0.39 6.37e-25 Intelligence (multi-trait analysis); BRCA cis rs66569888 0.754 rs6719028 chr2:106895212 T/C cg16099169 chr2:106886729 NA 0.77 15.98 0.53 1.28e-48 Facial morphology (factor 23); BRCA cis rs9393692 0.627 rs1059486 chr6:26200083 A/G cg05868516 chr6:26286170 HIST1H4H 0.39 8.39 0.31 3.19e-16 Educational attainment; BRCA cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg22800045 chr5:56110881 MAP3K1 0.64 12.05 0.43 2.94e-30 Initial pursuit acceleration; BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg22920501 chr2:26401640 FAM59B -0.66 -11.39 -0.41 1.74e-27 Gut microbiome composition (summer); BRCA cis rs765787 0.530 rs2668737 chr15:45522799 C/T cg24006582 chr15:45444508 DUOX1 -0.53 -10.95 -0.4 1.1e-25 Uric acid levels; BRCA cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg01483505 chr11:975446 AP2A2 0.33 9.01 0.34 2.41e-18 Alzheimer's disease (late onset); BRCA cis rs9309473 1.000 rs7594511 chr2:73681639 A/G cg20560298 chr2:73613845 ALMS1 -0.43 -10.57 -0.39 3.44e-24 Metabolite levels; BRCA cis rs6088580 0.634 rs6088508 chr20:33060081 A/G cg08999081 chr20:33150536 PIGU 0.47 13.06 0.46 1.04e-34 Glomerular filtration rate (creatinine); BRCA cis rs6461049 0.519 rs3778992 chr7:2175313 C/G cg14004847 chr7:1930337 MAD1L1 -0.42 -9.12 -0.34 9.98e-19 Schizophrenia; BRCA cis rs6088590 0.687 rs73106933 chr20:33287425 T/C cg08999081 chr20:33150536 PIGU 0.45 12.12 0.43 1.44e-30 Coronary artery disease; BRCA cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg21770322 chr7:97807741 LMTK2 0.44 11.55 0.42 3.81e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs10735851 1 rs10735851 chr12:53743064 G/A cg26875137 chr12:53738046 NA 0.42 11.05 0.4 4.24e-26 Total body bone mineral density; BRCA cis rs6120849 0.754 rs6120812 chr20:33629427 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs3771570 1.000 rs62193207 chr2:242318501 G/C cg21155796 chr2:242212141 HDLBP 0.6 9.19 0.34 5.62e-19 Prostate cancer; BRCA cis rs12545109 0.800 rs1996105 chr8:57413123 A/G cg09654669 chr8:57350985 NA -0.41 -7.94 -0.3 9.17e-15 Obesity-related traits; BRCA cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg03433033 chr1:76189801 ACADM -0.47 -9.8 -0.36 3.13e-21 Daytime sleep phenotypes; BRCA cis rs4285028 0.603 rs79312528 chr3:121608997 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.74 -13.25 -0.46 1.38e-35 Multiple sclerosis; BRCA cis rs7552404 0.727 rs5745427 chr1:76332637 C/A cg22875332 chr1:76189707 ACADM -0.52 -10.16 -0.37 1.37e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs875971 0.862 rs778680 chr7:65840414 G/A cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA trans rs6479891 0.915 rs10761744 chr10:65101026 C/G cg14819942 chr15:35414228 NA -0.34 -8.59 -0.32 6.8e-17 Arthritis (juvenile idiopathic); BRCA cis rs9858542 0.953 rs6766581 chr3:49539401 T/C cg03060546 chr3:49711283 APEH -0.53 -10.58 -0.39 3.33e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs3858526 0.642 rs10838783 chr11:5900282 T/G cg13902645 chr11:5959945 NA -0.4 -8.54 -0.32 1e-16 DNA methylation (variation); BRCA trans rs453301 0.658 rs12114954 chr8:8904862 T/G cg21775007 chr8:11205619 TDH -0.37 -7.81 -0.3 2.43e-14 Joint mobility (Beighton score); BRCA cis rs2204008 0.743 rs11495614 chr12:38156358 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.32 0.35 1.92e-19 Bladder cancer; BRCA cis rs782590 0.935 rs2627779 chr2:55892356 A/G cg18811423 chr2:55921094 PNPT1 0.76 25.28 0.71 2.82e-98 Metabolic syndrome; BRCA cis rs1153858 1.000 rs4775911 chr15:45649787 G/T cg14582100 chr15:45693742 SPATA5L1 -0.37 -12.22 -0.44 5.31e-31 Homoarginine levels; BRCA cis rs7727544 0.735 rs274557 chr5:131721204 T/C cg07395648 chr5:131743802 NA 0.37 9.35 0.35 1.4e-19 Blood metabolite levels; BRCA cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA trans rs2204008 0.806 rs11525001 chr12:38234397 A/G cg06521331 chr12:34319734 NA -0.52 -9.99 -0.37 6.29e-22 Bladder cancer; BRCA cis rs365132 0.967 rs353471 chr5:176363429 T/C cg16309518 chr5:176445507 NA -0.52 -13.47 -0.47 1.45e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7267979 0.933 rs11699203 chr20:25435169 G/C cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg09877947 chr5:131593287 PDLIM4 0.41 10.37 0.38 2.21e-23 Breast cancer; BRCA cis rs1865760 1.000 rs3830057 chr6:25918510 G/T cg16482183 chr6:26056742 HIST1H1C 0.55 11.45 0.41 9.94e-28 Height; BRCA cis rs6981523 0.553 rs2409730 chr8:11060638 C/A cg21775007 chr8:11205619 TDH -0.49 -9.62 -0.36 1.45e-20 Neuroticism; BRCA cis rs881375 1.000 rs6478486 chr9:123655329 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.6 0.32 6.11e-17 Rheumatoid arthritis; BRCA cis rs7927771 0.507 rs1483988 chr11:47899030 C/T cg20307385 chr11:47447363 PSMC3 0.43 9.53 0.35 3.15e-20 Subjective well-being; BRCA cis rs9487051 1.000 rs13191948 chr6:109634599 C/T cg01475377 chr6:109611718 NA -0.52 -13.05 -0.46 1.17e-34 Reticulocyte fraction of red cells; BRCA cis rs6545883 0.929 rs2593625 chr2:61668769 C/T cg15711740 chr2:61764176 XPO1 -0.56 -14.31 -0.49 1.67e-40 Tuberculosis; BRCA trans rs7824557 0.701 rs4568582 chr8:11160495 A/T cg08975724 chr8:8085496 FLJ10661 0.43 8.13 0.31 2.19e-15 Retinal vascular caliber; BRCA cis rs9300255 0.602 rs1569068 chr12:123632276 A/G cg00376283 chr12:123451042 ABCB9 -0.46 -10.05 -0.37 3.67e-22 Neutrophil percentage of white cells; BRCA cis rs7809950 1.000 rs2520265 chr7:107181231 A/G cg23024343 chr7:107201750 COG5 -0.4 -9.05 -0.34 1.65e-18 Coronary artery disease; BRCA cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg00631329 chr6:26305371 NA -0.46 -13.06 -0.46 9.65e-35 Educational attainment; BRCA cis rs11711311 1.000 rs62268168 chr3:113489447 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.04 -0.37 4.16e-22 IgG glycosylation; BRCA cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg04518342 chr5:131593106 PDLIM4 0.34 8.3 0.31 6.34e-16 Blood metabolite levels; BRCA cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11890956 chr21:40555474 PSMG1 -0.52 -10.89 -0.4 1.91e-25 Menarche (age at onset); BRCA cis rs2346177 0.605 rs7556828 chr2:46663172 A/G cg26688816 chr2:46740690 ATP6V1E2 0.4 8.72 0.33 2.31e-17 HDL cholesterol; BRCA cis rs1797081 1.000 rs2603807 chr10:16872797 A/G cg23933602 chr10:16859644 RSU1 0.92 26.79 0.73 1.39e-106 Platelet distribution width; BRCA cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg06115741 chr20:33292138 TP53INP2 0.36 7.98 0.3 6.59e-15 Glomerular filtration rate (creatinine); BRCA cis rs4290604 0.748 rs4549025 chr2:238052911 C/T cg23555395 chr2:238036564 NA 0.51 8.28 0.31 7.02e-16 Asthma; BRCA cis rs4642101 0.680 rs7626609 chr3:12806080 A/G cg24848339 chr3:12840334 CAND2 -0.41 -10.82 -0.39 3.68e-25 QRS complex (12-leadsum); BRCA cis rs3768617 0.966 rs6669796 chr1:183082825 G/C ch.1.3577855R chr1:183094577 LAMC1 0.47 10.33 0.38 3.14e-23 Fuchs's corneal dystrophy; BRCA cis rs870825 1.000 rs870821 chr4:185587377 T/C cg04058563 chr4:185651563 MLF1IP 0.67 12.18 0.43 7.78e-31 Blood protein levels; BRCA cis rs17401966 1.000 rs12118323 chr1:10469641 A/G cg03954927 chr1:10346856 KIF1B 0.47 13.89 0.48 1.59e-38 Hepatocellular carcinoma; BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 14.31 0.49 1.63e-40 Alzheimer's disease; BRCA cis rs5753618 0.583 rs5749279 chr22:31854209 A/G cg02404636 chr22:31891804 SFI1 0.39 8.76 0.33 1.71e-17 Colorectal cancer; BRCA cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg02659138 chr7:134003124 SLC35B4 0.34 10.79 0.39 4.94e-25 Mean platelet volume; BRCA cis rs1153858 1.000 rs11070456 chr15:45686835 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.47 0.41 8.15e-28 Homoarginine levels; BRCA cis rs62458065 0.640 rs28587905 chr7:32533054 C/T cg20159608 chr7:32802032 NA -0.47 -8.42 -0.32 2.47e-16 Metabolite levels (HVA/MHPG ratio); BRCA cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg02659138 chr7:134003124 SLC35B4 0.36 10.36 0.38 2.37e-23 Mean platelet volume; BRCA cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1499972 0.941 rs55734908 chr3:117613268 A/T cg07612923 chr3:117604196 NA 0.59 8.01 0.3 5.48e-15 Schizophrenia; BRCA cis rs7072216 0.763 rs7091709 chr10:100167605 G/A cg26618903 chr10:100175079 PYROXD2 -0.31 -9.03 -0.34 2.08e-18 Metabolite levels; BRCA cis rs7267979 1.000 rs11087520 chr20:25436827 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.13 0.34 8.54e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11792861 0.591 rs4978763 chr9:111728067 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.57 12.84 0.45 1.01e-33 Menarche (age at onset); BRCA cis rs9399135 0.935 rs9376086 chr6:135371329 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.66e-31 Red blood cell count; BRCA cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.97e-35 Bone mineral density; BRCA cis rs3125734 0.633 rs4979754 chr10:64048959 G/A cg19640130 chr10:64028056 RTKN2 -0.35 -9.76 -0.36 4.64e-21 Rheumatoid arthritis; BRCA cis rs12540874 0.542 rs4947582 chr7:50566090 C/T cg18232548 chr7:50535776 DDC -0.5 -12.55 -0.44 1.93e-32 Systemic sclerosis; BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg03609598 chr5:56110824 MAP3K1 -0.46 -8.11 -0.31 2.53e-15 Initial pursuit acceleration; BRCA cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.84 0.36 2.36e-21 Bipolar disorder; BRCA cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg11812906 chr14:75593930 NEK9 -0.59 -13.33 -0.47 6.23e-36 Height; BRCA cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.25 -0.41 6.69e-27 Schizophrenia; BRCA cis rs10465746 0.967 rs12118434 chr1:84328629 C/T cg10977910 chr1:84465055 TTLL7 0.51 10.41 0.38 1.45e-23 Obesity-related traits; BRCA cis rs6088590 0.561 rs6059932 chr20:33175466 C/T cg08999081 chr20:33150536 PIGU 0.5 14.23 0.49 4.29e-40 Coronary artery disease; BRCA cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg17143192 chr8:8559678 CLDN23 0.5 9.8 0.36 3.2e-21 Obesity-related traits; BRCA cis rs6062302 0.522 rs2297427 chr20:62221364 G/A cg16989086 chr20:62203971 PRIC285 0.53 9.0 0.34 2.63e-18 Glioblastoma; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.59 -10.36 -0.38 2.36e-23 Gut microbiome composition (summer); BRCA cis rs736408 0.509 rs3774349 chr3:52722335 A/C cg20224285 chr3:52813920 ITIH1 0.32 8.02 0.3 4.98e-15 Bipolar disorder; BRCA cis rs11971779 0.688 rs8137 chr7:139104461 A/C cg07862535 chr7:139043722 LUC7L2 -0.38 -10.21 -0.37 8.75e-23 Diisocyanate-induced asthma; BRCA cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg10802521 chr3:52805072 NEK4 -0.32 -8.1 -0.31 2.73e-15 Bipolar disorder; BRCA cis rs7666738 0.830 rs1593569 chr4:99017485 C/G cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 8.91e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg13047869 chr3:10149882 C3orf24 0.6 12.67 0.45 5.42e-33 Alzheimer's disease; BRCA cis rs6700896 0.931 rs2154382 chr1:66131681 C/T cg04111102 chr1:66153794 NA 0.36 8.82 0.33 1.08e-17 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg08885076 chr2:99613938 TSGA10 0.46 10.83 0.39 3.42e-25 Chronic sinus infection; BRCA cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg14863265 chr7:2801509 GNA12 -0.42 -9.61 -0.36 1.63e-20 Height; BRCA cis rs17253792 0.822 rs79024594 chr14:56092997 T/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg15556689 chr8:8085844 FLJ10661 -0.47 -12.97 -0.46 2.59e-34 Mood instability; BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg18230493 chr5:56204884 C5orf35 -0.67 -13.33 -0.47 6.06e-36 Initial pursuit acceleration; BRCA cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg11266682 chr4:10021025 SLC2A9 0.48 12.72 0.45 3.27e-33 Bone mineral density; BRCA trans rs4650994 0.524 rs2761465 chr1:178579404 G/T cg05059571 chr16:84539110 KIAA1609 0.57 12.47 0.44 4.05e-32 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.52 -0.52 2.52e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg05347473 chr6:146136440 FBXO30 0.41 8.06 0.3 3.74e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg02297831 chr4:17616191 MED28 0.36 8.36 0.31 3.79e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9381107 0.932 rs13219694 chr6:9422441 T/G cg14735645 chr6:9486422 NA -0.47 -8.17 -0.31 1.65e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs4975709 0.610 rs4975705 chr5:1860359 T/C cg01114163 chr5:1856713 NA -0.36 -8.08 -0.3 3.36e-15 Cardiovascular disease risk factors; BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg00149659 chr3:10157352 C3orf10 0.73 10.74 0.39 7.58e-25 Alzheimer's disease; BRCA cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg10556349 chr10:835070 NA 0.63 8.74 0.33 2.06e-17 Eosinophil percentage of granulocytes; BRCA cis rs7737355 1.000 rs2158428 chr5:130751481 T/A cg06307176 chr5:131281290 NA -0.51 -10.06 -0.37 3.24e-22 Life satisfaction; BRCA cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.51 0.35 3.74e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs2197308 0.765 rs11182434 chr12:37923968 C/A cg06521331 chr12:34319734 NA -0.54 -9.58 -0.35 2.16e-20 Morning vs. evening chronotype; BRCA cis rs4819852 1.000 rs1034566 chr22:19984277 C/T cg07821417 chr22:19972146 ARVCF 0.48 10.8 0.39 4.51e-25 Pulse pressure; BRCA cis rs17253792 0.822 rs17746106 chr14:56069168 C/T cg01858014 chr14:56050164 KTN1 -0.59 -9.53 -0.35 3.28e-20 Putamen volume; BRCA cis rs7904368 0.806 rs7099178 chr10:16862578 C/G cg14835575 chr10:16859367 RSU1 0.61 12.46 0.44 4.7e-32 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg11266682 chr4:10021025 SLC2A9 -0.42 -11.14 -0.4 1.82e-26 Bone mineral density; BRCA cis rs4595586 0.545 rs12814188 chr12:39380853 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.45 0.41 9.48e-28 Rheumatoid arthritis; BRCA cis rs9790314 0.632 rs55672403 chr3:160681026 C/A cg03342759 chr3:160939853 NMD3 0.45 8.71 0.33 2.5e-17 Morning vs. evening chronotype; BRCA trans rs3857536 0.842 rs2188590 chr6:66939534 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs9283706 0.689 rs10041705 chr5:66317222 C/T cg11590213 chr5:66331682 MAST4 -0.41 -7.89 -0.3 1.31e-14 Coronary artery disease; BRCA cis rs2859741 0.546 rs3934329 chr1:37504523 C/T cg09363841 chr1:37513479 NA -0.52 -11.17 -0.4 1.35e-26 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs7267979 0.932 rs417130 chr20:25458320 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.29 8.34 0.31 4.5e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs28735056 0.904 rs72980087 chr18:77632194 G/A cg20368463 chr18:77673604 PQLC1 -0.34 -8.0 -0.3 5.75e-15 Schizophrenia; BRCA cis rs9287719 0.753 rs1990613 chr2:10781975 C/T cg00105475 chr2:10696890 NA -0.43 -10.26 -0.38 5.74e-23 Prostate cancer; BRCA cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg27572855 chr1:25598939 RHD 0.45 12.93 0.46 3.79e-34 Erythrocyte sedimentation rate; BRCA cis rs2832191 0.903 rs11700687 chr21:30486767 A/G cg24692254 chr21:30365293 RNF160 -0.59 -15.06 -0.51 4.31e-44 Dental caries; BRCA cis rs7772486 0.686 rs9497396 chr6:146014963 C/A cg23711669 chr6:146136114 FBXO30 -0.7 -16.55 -0.55 1.88e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs9919333 chr1:152968744 G/T cg25856811 chr1:152973957 SPRR3 -0.34 -8.98 -0.33 3.11e-18 Inflammatory skin disease; BRCA cis rs2070488 0.965 rs7372849 chr3:38524328 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.69 19.23 0.61 2.41e-65 Electrocardiographic conduction measures; BRCA cis rs7945718 0.967 rs11826129 chr11:12768883 G/A cg25843174 chr11:12811716 TEAD1 0.23 8.65 0.32 4.09e-17 Educational attainment (years of education); BRCA cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.1e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.12 0.34 9.81e-19 Alzheimer's disease; BRCA cis rs6089584 0.888 rs6142927 chr20:60605848 A/G cg06108461 chr20:60628389 TAF4 -0.86 -15.77 -0.53 1.47e-47 Body mass index; BRCA cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.33e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.79 -19.22 -0.61 2.53e-65 Multiple sclerosis; BRCA cis rs7737355 0.947 rs7720339 chr5:130837134 T/C cg06307176 chr5:131281290 NA 0.54 10.64 0.39 1.94e-24 Life satisfaction; BRCA cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg05283184 chr6:79620031 NA -0.42 -10.85 -0.39 2.67e-25 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs3922842 chr6:25736564 T/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg17971929 chr21:40555470 PSMG1 -0.44 -9.22 -0.34 4.18e-19 Menarche (age at onset); BRCA cis rs13108904 0.901 rs7695691 chr4:1304632 A/G cg16405210 chr4:1374714 KIAA1530 -0.38 -8.27 -0.31 7.56e-16 Obesity-related traits; BRCA cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg26587870 chr6:27730563 NA -0.4 -8.59 -0.32 6.5e-17 Parkinson's disease; BRCA cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg23583168 chr7:148888333 NA -0.85 -19.99 -0.62 2.15e-69 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg09184832 chr6:79620586 NA -0.48 -10.46 -0.38 9.77e-24 Intelligence (multi-trait analysis); BRCA cis rs9818758 0.607 rs73082362 chr3:49113729 C/T cg00383909 chr3:49044727 WDR6 0.97 13.43 0.47 2.23e-36 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg06238570 chr21:40685208 BRWD1 -0.46 -9.05 -0.34 1.73e-18 Cognitive function; BRCA cis rs12310956 0.532 rs1352211 chr12:33983132 G/A cg06521331 chr12:34319734 NA -0.56 -10.84 -0.39 2.95e-25 Morning vs. evening chronotype; BRCA trans rs11992162 0.967 rs10088415 chr8:11830825 A/G cg14343924 chr8:8086146 FLJ10661 -0.38 -7.9 -0.3 1.23e-14 Monocyte count; BRCA cis rs7092929 0.574 rs7074352 chr10:3538749 G/T cg14308648 chr10:3568949 NA 0.42 9.67 0.36 9.64e-21 Coronary artery calcification; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.94e-30 Tonsillectomy; BRCA cis rs9649465 0.561 rs609953 chr7:123422444 T/A cg03229431 chr7:123269106 ASB15 0.43 9.68 0.36 9.34e-21 Migraine; BRCA cis rs769267 1.000 rs2074089 chr19:19449603 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.58 -0.35 2.17e-20 Tonsillectomy; BRCA trans rs561341 0.769 rs7217004 chr17:30178092 A/G cg27661571 chr11:113659931 NA 0.65 8.71 0.33 2.53e-17 Hip circumference adjusted for BMI; BRCA cis rs2204008 0.774 rs9669565 chr12:38294428 C/A cg13010199 chr12:38710504 ALG10B 0.5 10.56 0.39 4.03e-24 Bladder cancer; BRCA cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg24531977 chr5:56204891 C5orf35 -0.66 -13.23 -0.46 1.79e-35 Type 2 diabetes; BRCA cis rs3768617 0.510 rs10911249 chr1:183080690 G/A ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg17971929 chr21:40555470 PSMG1 -0.62 -14.48 -0.5 2.58e-41 Cognitive function; BRCA cis rs597539 0.652 rs636049 chr11:68667198 A/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 19.67 0.61 1.1e-67 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg05025164 chr4:1340916 KIAA1530 0.77 15.38 0.52 1.16e-45 Longevity; BRCA trans rs2832077 0.883 rs35672956 chr21:30189042 T/C cg14791747 chr16:20752902 THUMPD1 0.4 9.35 0.35 1.51e-19 Cognitive test performance; BRCA cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.26 0.38 5.83e-23 Bladder cancer; BRCA cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg11752832 chr7:134001865 SLC35B4 0.48 11.98 0.43 5.36e-30 Mean platelet volume; BRCA cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg18225595 chr11:63971243 STIP1 0.41 10.06 0.37 3.44e-22 Platelet count; BRCA cis rs11677370 0.603 rs10174064 chr2:3849806 C/T cg17052675 chr2:3827356 NA -0.52 -12.85 -0.45 8.97e-34 Type 2 diabetes; BRCA cis rs9787249 0.957 rs11206754 chr1:40216234 A/G cg02773041 chr1:40204384 PPIE 0.45 9.7 0.36 7.64e-21 Blood protein levels; BRCA cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg05535760 chr7:792225 HEATR2 -0.79 -14.09 -0.49 1.86e-39 Cerebrospinal P-tau181p levels; BRCA trans rs2270927 0.790 rs4566770 chr5:75576313 A/G cg13563193 chr19:33072644 PDCD5 -0.72 -11.08 -0.4 3.28e-26 Mean corpuscular volume; BRCA cis rs9612 1.000 rs2277745 chr19:44259077 C/T cg08581076 chr19:44259116 C19orf61 0.59 10.44 0.38 1.18e-23 Exhaled nitric oxide output; BRCA cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg04719120 chr6:96025338 MANEA 0.51 7.81 0.3 2.29e-14 Behavioural disinhibition (generation interaction); BRCA cis rs2153535 0.601 rs1855768 chr6:8472969 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs7091068 0.518 rs1572772 chr10:95432862 A/G cg20715218 chr10:95462985 C10orf4 -0.44 -9.33 -0.35 1.69e-19 Urinary tract infection frequency; BRCA cis rs9291683 0.588 rs2240724 chr4:10021290 G/C cg00071950 chr4:10020882 SLC2A9 0.65 16.48 0.55 4.18e-51 Bone mineral density; BRCA cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.31 0.31 5.74e-16 Rheumatoid arthritis; BRCA cis rs6582630 0.555 rs11182148 chr12:38464883 A/C cg26384229 chr12:38710491 ALG10B 0.67 15.99 0.53 1.15e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg22875332 chr1:76189707 ACADM 0.69 14.76 0.5 1.23e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg24642439 chr20:33292090 TP53INP2 0.56 12.29 0.44 2.59e-31 Coronary artery disease; BRCA cis rs8114671 0.836 rs6060140 chr20:33566507 G/A cg07148914 chr20:33460835 GGT7 0.43 9.28 0.34 2.66e-19 Height; BRCA cis rs2075371 1.000 rs2544218 chr7:133992315 C/A cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.7800000000000005e-38 Mean platelet volume; BRCA cis rs10870270 0.956 rs7894 chr10:133769482 G/C cg17892150 chr10:133769511 PPP2R2D -0.72 -15.45 -0.52 5.26e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7659604 0.539 rs7660548 chr4:122730821 G/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.38 -0.44 1.06e-31 Type 2 diabetes; BRCA cis rs4800452 0.956 rs4239437 chr18:20732224 A/G cg26136497 chr18:20735537 CABLES1 -0.47 -11.63 -0.42 1.72e-28 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs6088813 1.000 rs1540927 chr20:33931344 A/G cg14752227 chr20:34000481 UQCC -0.39 -8.46 -0.32 1.83e-16 Height; BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg01262667 chr19:19385393 TM6SF2 0.4 10.46 0.38 9.53e-24 Tonsillectomy; BRCA cis rs12220238 1.000 rs10824076 chr10:75886956 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.49 8.06 0.3 3.65e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 7.17e-41 Motion sickness; BRCA cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg17971929 chr21:40555470 PSMG1 0.76 16.54 0.55 2.08e-51 Cognitive function; BRCA cis rs7246657 0.722 rs10402671 chr19:38117086 C/T cg18154014 chr19:37997991 ZNF793 0.5 9.59 0.35 1.99e-20 Coronary artery calcification; BRCA cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg06636001 chr8:8085503 FLJ10661 0.65 14.92 0.51 2.04e-43 Mood instability; BRCA cis rs6901250 0.851 rs7760125 chr6:117123391 A/C cg12892004 chr6:117198278 RFX6 0.49 11.44 0.41 1.03e-27 C-reactive protein levels; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg08470875 chr2:26401718 FAM59B -0.68 -10.67 -0.39 1.44e-24 Gut microbiome composition (summer); BRCA trans rs1973993 0.689 rs17115225 chr1:96884330 C/T cg10631902 chr5:14652156 NA -0.45 -12.52 -0.44 2.49e-32 Weight; BRCA cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.48 0.41 7.08e-28 Monocyte percentage of white cells; BRCA cis rs1788820 0.843 rs1788821 chr18:21120869 A/G cg14672496 chr18:21087552 C18orf8 0.35 8.43 0.32 2.34e-16 Body mass index; BRCA cis rs9859260 0.710 rs34906439 chr3:195779706 A/G cg03462622 chr3:195777018 TFRC -0.38 -8.63 -0.32 4.86e-17 Mean corpuscular volume; BRCA cis rs9325144 0.505 rs6582691 chr12:38806894 T/C cg26384229 chr12:38710491 ALG10B -0.58 -15.11 -0.51 2.36e-44 Morning vs. evening chronotype; BRCA trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -8.03 -0.3 4.53e-15 Corneal astigmatism; BRCA cis rs7246657 0.943 rs7255785 chr19:37971683 C/T cg14683738 chr19:37701593 ZNF585B 0.45 8.03 0.3 4.85e-15 Coronary artery calcification; BRCA cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.67 0.45 5.53e-33 Mean platelet volume; BRCA cis rs2797160 0.967 rs28629380 chr6:126004197 A/G cg05901451 chr6:126070800 HEY2 -0.38 -9.17 -0.34 6.55e-19 Endometrial cancer; BRCA cis rs6988985 0.678 rs7831617 chr8:144002283 G/T cg01972576 chr8:143916273 GML 0.34 9.89 0.36 1.43e-21 Plasma androstenedione levels in resected early stage-receptor positive breast cancer; BRCA cis rs61990749 0.544 rs7151211 chr14:78151901 C/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.63 -9.65 -0.36 1.13e-20 Fibroblast growth factor basic levels; BRCA cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.74 -0.33 2.11e-17 Colorectal cancer; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg02353165 chr6:42928485 GNMT 0.76 18.87 0.6 1.91e-63 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs35851103 0.507 rs6601649 chr8:11857317 A/G cg06636001 chr8:8085503 FLJ10661 -0.4 -8.26 -0.31 8.17e-16 Neuroticism; BRCA cis rs6973256 0.897 rs2483507 chr7:133339546 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA cis rs35146811 0.695 rs1623264 chr7:99811204 G/C cg13334819 chr7:99746414 C7orf59 0.34 7.92 0.3 1.06e-14 Coronary artery disease; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg04944784 chr2:26401820 FAM59B -0.67 -11.31 -0.41 3.69e-27 Gut microbiome composition (summer); BRCA trans rs12310956 0.510 rs10844690 chr12:33854752 C/A cg26384229 chr12:38710491 ALG10B 0.39 9.04 0.34 1.89e-18 Morning vs. evening chronotype; BRCA trans rs61931739 0.517 rs1843738 chr12:34056935 C/T cg26384229 chr12:38710491 ALG10B 0.68 14.37 0.49 9.31e-41 Morning vs. evening chronotype; BRCA cis rs2276314 1.000 rs2276314 chr18:33557466 C/T cg05985134 chr18:33552581 C18orf21 -0.7 -13.55 -0.47 5.95e-37 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg00599163 chr2:162100495 NA 0.28 8.96 0.33 3.42e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.31 -0.38 3.63e-23 Gut microbiome composition (summer); BRCA cis rs1577917 0.545 rs7755958 chr6:86488511 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.34 9.25 0.34 3.44e-19 Response to antipsychotic treatment; BRCA cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg14019146 chr3:50243930 SLC38A3 0.36 8.96 0.33 3.53e-18 Body mass index; BRCA cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg07636037 chr3:49044803 WDR6 0.94 26.36 0.72 3.23e-104 Parkinson's disease; BRCA trans rs6762477 0.748 rs34877766 chr3:50234126 A/G cg21659725 chr3:3221576 CRBN 0.36 8.52 0.32 1.17e-16 Menarche (age at onset); BRCA cis rs9733 0.596 rs72700897 chr1:150626038 C/G cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs9814567 1.000 rs13081688 chr3:134259954 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.7 0.61 7.2e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.96 26.59 0.72 1.94e-105 Birth weight; BRCA cis rs7729447 0.813 rs10941022 chr5:32691416 C/T cg16267343 chr5:32710456 NPR3 0.43 8.92 0.33 4.69e-18 Blood pressure; BRCA cis rs4932217 0.579 rs150302 chr15:89946789 C/G cg25932290 chr15:89939252 LOC254559 -0.28 -8.85 -0.33 8.24e-18 Height; BRCA cis rs6860806 0.507 rs2631362 chr5:131707293 A/G cg12564285 chr5:131593104 PDLIM4 -0.34 -7.86 -0.3 1.66e-14 Breast cancer; BRCA cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 12.71 0.45 3.9e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6964587 0.692 rs2299233 chr7:91626953 C/T cg17063962 chr7:91808500 NA -0.56 -12.76 -0.45 2.13e-33 Breast cancer; BRCA cis rs6964587 1.000 rs3753107 chr7:91629151 C/T cg17063962 chr7:91808500 NA -0.57 -13.36 -0.47 4.6e-36 Breast cancer; BRCA cis rs10992471 0.756 rs7027595 chr9:95131553 C/T cg14631576 chr9:95140430 CENPP -0.37 -9.02 -0.34 2.22e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7666738 0.830 rs7662948 chr4:99020132 G/C cg05340658 chr4:99064831 C4orf37 0.69 17.4 0.57 8.22e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs611744 0.647 rs615126 chr8:109247619 C/T cg21045802 chr8:109455806 TTC35 0.35 8.03 0.3 4.64e-15 Dupuytren's disease; BRCA cis rs9527 0.590 rs11191553 chr10:104851396 G/T cg04362960 chr10:104952993 NT5C2 0.45 10.32 0.38 3.52e-23 Arsenic metabolism; BRCA cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg26031613 chr14:104095156 KLC1 -0.42 -8.32 -0.31 5.33e-16 Schizophrenia; BRCA cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg21433313 chr16:3507492 NAT15 0.47 10.44 0.38 1.12e-23 Tuberculosis; BRCA cis rs636291 0.517 rs670666 chr1:10549380 C/T cg07384165 chr1:10488281 NA 0.4 8.59 0.32 6.46e-17 Prostate cancer; BRCA cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.21e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg06064525 chr11:970664 AP2A2 -0.33 -9.81 -0.36 2.86e-21 Alzheimer's disease (late onset); BRCA cis rs2795502 0.882 rs2744093 chr10:43339243 A/G cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs34779708 0.897 rs7897827 chr10:35386237 C/T cg03585969 chr10:35415529 CREM 0.5 10.48 0.38 7.81e-24 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10193935 0.818 rs10221927 chr2:42546680 A/C cg27598129 chr2:42591480 NA -0.9 -14.5 -0.5 2.09e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs4076764 1.000 rs4469696 chr1:163424565 C/T cg06092702 chr1:163392909 NA -0.32 -8.48 -0.32 1.57e-16 Motion sickness; BRCA cis rs250677 0.522 rs4705302 chr5:148354962 G/C cg18129178 chr5:148520854 ABLIM3 0.54 10.48 0.38 8.11e-24 Breast cancer; BRCA cis rs7086627 0.515 rs11202959 chr10:82209672 A/G cg01528321 chr10:82214614 TSPAN14 0.62 14.12 0.49 1.3e-39 Post bronchodilator FEV1; BRCA cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg04586622 chr2:25135609 ADCY3 0.46 11.53 0.41 4.52e-28 Body mass index; BRCA cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.54 0.61 5.15e-67 Cognitive function; BRCA cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.64 -0.32 4.48e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs503734 0.521 rs348881 chr3:100970920 A/C cg27318481 chr3:100970896 IMPG2 -0.41 -9.98 -0.37 6.83e-22 Inflammatory bowel disease;Crohn's disease; BRCA trans rs35110281 0.720 rs230647 chr21:44919654 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.44 -8.23 -0.31 1.07e-15 Mean corpuscular volume; BRCA cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg18132916 chr6:79620363 NA -0.49 -11.13 -0.4 1.93e-26 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg08888203 chr3:10149979 C3orf24 -0.54 -9.99 -0.37 6.25e-22 Alzheimer's disease; BRCA cis rs13223928 0.651 rs4722426 chr7:3150697 C/T cg19214707 chr7:3157722 NA 0.44 11.08 0.4 3.14e-26 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA cis rs208520 0.545 rs10944874 chr6:66752080 C/T cg07460842 chr6:66804631 NA -1.0 -27.09 -0.73 3.19e-108 Exhaled nitric oxide output; BRCA cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.66 0.42 1.31e-28 Homoarginine levels; BRCA cis rs6582630 0.519 rs8189599 chr12:38280748 A/G cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 2.16e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs13053817 0.904 rs13053624 chr22:29838203 A/T cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.5 -9.83 -0.36 2.57e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg21427119 chr20:30132790 HM13 -0.41 -8.69 -0.33 2.96e-17 Mean corpuscular hemoglobin; BRCA cis rs6121246 0.609 rs6060983 chr20:30420924 T/C cg13852791 chr20:30311386 BCL2L1 0.86 18.96 0.6 6.11e-64 Mean corpuscular hemoglobin; BRCA cis rs10193935 0.792 rs222472 chr2:42662911 C/T cg27598129 chr2:42591480 NA -0.71 -12.05 -0.43 2.91e-30 Colonoscopy-negative controls vs population controls; BRCA cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg08514558 chr10:81106712 PPIF 0.38 8.69 0.33 2.93e-17 Height; BRCA cis rs61931739 0.534 rs7302688 chr12:34235064 A/G cg06521331 chr12:34319734 NA -0.64 -11.81 -0.42 2.95e-29 Morning vs. evening chronotype; BRCA cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg18479299 chr3:125709523 NA -0.53 -8.22 -0.31 1.15e-15 Blood pressure (smoking interaction); BRCA cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg18479299 chr3:125709523 NA -0.51 -8.62 -0.32 5.34e-17 Blood pressure (smoking interaction); BRCA cis rs10028773 0.568 rs6838457 chr4:120267367 A/G cg09307838 chr4:120376055 NA 0.59 12.89 0.45 5.65e-34 Educational attainment; BRCA cis rs9814567 1.000 rs9289476 chr3:134237103 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.49 -0.61 9.03e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1451375 0.669 rs10274172 chr7:50637575 G/A cg18232548 chr7:50535776 DDC -0.38 -8.82 -0.33 1.04e-17 Malaria; BRCA cis rs10463316 0.817 rs12653378 chr5:150802366 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.62 -0.32 5.06e-17 Metabolite levels (Pyroglutamine); BRCA cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg12011299 chr4:100065546 ADH4 0.48 11.06 0.4 3.79e-26 Alcohol dependence; BRCA cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg17420585 chr12:42539391 GXYLT1 -0.38 -7.99 -0.3 6.3e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg11279151 chr3:101281821 RG9MTD1 -0.39 -8.78 -0.33 1.48e-17 Colorectal cancer; BRCA cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14442939 chr10:27389572 ANKRD26 -0.68 -10.76 -0.39 6.52e-25 Breast cancer; BRCA cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg08999081 chr20:33150536 PIGU 0.47 12.96 0.46 3e-34 Glomerular filtration rate (creatinine); BRCA cis rs4664304 0.620 rs11675085 chr2:160713352 C/G cg14819504 chr2:160761413 LY75 0.34 8.5 0.32 1.38e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg16145915 chr7:1198662 ZFAND2A -0.6 -14.76 -0.5 1.18e-42 Longevity;Endometriosis; BRCA cis rs6964587 0.839 rs6952459 chr7:91435820 T/A cg17063962 chr7:91808500 NA 0.49 11.14 0.4 1.8e-26 Breast cancer; BRCA cis rs910316 0.737 rs175072 chr14:75502827 T/C cg11812906 chr14:75593930 NEK9 -0.59 -13.45 -0.47 1.79e-36 Height; BRCA cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg11657440 chr19:46296263 DMWD -0.59 -14.09 -0.49 1.88e-39 Coronary artery disease; BRCA cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg10820045 chr2:198174542 NA -0.45 -10.59 -0.39 3.03e-24 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs28735056 1.000 rs56376220 chr18:77609462 C/T cg20368463 chr18:77673604 PQLC1 -0.34 -7.94 -0.3 9.45e-15 Schizophrenia; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg00166722 chr3:10149974 C3orf24 0.64 11.32 0.41 3.47e-27 Alzheimer's disease; BRCA cis rs2637030 0.559 rs2636991 chr5:52943067 T/G cg06476337 chr5:52856530 NDUFS4 0.37 8.54 0.32 9.77e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs11971779 0.680 rs6978680 chr7:139112048 A/G cg07862535 chr7:139043722 LUC7L2 -0.38 -10.2 -0.37 9.55e-23 Diisocyanate-induced asthma; BRCA cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg23229984 chr5:148520753 ABLIM3 0.35 8.13 0.31 2.18e-15 Breast cancer; BRCA cis rs2839186 0.526 rs59977673 chr21:47922091 C/T cg12379764 chr21:47803548 PCNT -0.41 -9.15 -0.34 7.55e-19 Testicular germ cell tumor; BRCA cis rs758324 0.947 rs2404778 chr5:131172886 T/C cg06307176 chr5:131281290 NA 0.56 11.7 0.42 8.56e-29 Alzheimer's disease in APOE e4- carriers; BRCA cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg06197492 chr11:2016605 H19 0.41 8.44 0.32 2.2e-16 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs72772090 0.908 rs11750510 chr5:96042095 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.53 -11.54 -0.42 4.05e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7927592 0.913 rs4988291 chr11:68381607 G/A cg20283391 chr11:68216788 NA -0.46 -9.22 -0.34 4.1e-19 Total body bone mineral density; BRCA cis rs68170813 0.559 rs4730229 chr7:106925353 A/G cg02696742 chr7:106810147 HBP1 -0.53 -8.57 -0.32 7.9e-17 Coronary artery disease; BRCA cis rs28374715 0.662 rs10851403 chr15:41466087 T/G cg18705301 chr15:41695430 NDUFAF1 -0.84 -17.53 -0.57 1.92e-56 Ulcerative colitis; BRCA cis rs6701037 0.681 rs1894709 chr1:175132371 G/T cg00321850 chr1:175162397 KIAA0040 -0.41 -11.41 -0.41 1.46e-27 Alcohol dependence; BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg27170947 chr2:26402098 FAM59B -0.93 -17.28 -0.56 3.64e-55 Gut microbiome composition (summer); BRCA cis rs1348850 0.526 rs7582179 chr2:178370631 A/G cg27490568 chr2:178487706 NA 0.49 8.21 0.31 1.26e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs12188164 0.525 rs1114665 chr5:452247 C/T cg16584290 chr5:462447 EXOC3 0.52 14.37 0.49 9.25e-41 Cystic fibrosis severity; BRCA cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.6 0.32 5.94e-17 Rheumatoid arthritis; BRCA cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 10.97 0.4 8.58e-26 Intelligence (multi-trait analysis); BRCA cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg23029597 chr12:123009494 RSRC2 -0.49 -9.92 -0.37 1.17e-21 Body mass index; BRCA cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg00677455 chr12:58241039 CTDSP2 0.47 11.06 0.4 4e-26 Intelligence (multi-trait analysis); BRCA cis rs13095912 1.000 rs13095912 chr3:185302098 G/A cg11274856 chr3:185301563 NA 0.36 9.0 0.34 2.59e-18 Systolic blood pressure; BRCA cis rs6866344 0.570 rs4266420 chr5:178137161 C/G cg10224037 chr5:178157518 ZNF354A 0.79 18.14 0.58 1.26e-59 Neutrophil percentage of white cells; BRCA cis rs4555082 0.830 rs2816614 chr14:105727359 C/T cg27165867 chr14:105738592 BRF1 -0.35 -8.28 -0.31 6.96e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg02503808 chr4:7069936 GRPEL1 -0.78 -14.35 -0.49 1.05e-40 Monocyte percentage of white cells; BRCA cis rs703842 0.739 rs701008 chr12:58117645 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.47 9.4 0.35 9.18e-20 Multiple sclerosis; BRCA cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg20203395 chr5:56204925 C5orf35 -0.51 -10.63 -0.39 2.13e-24 Initial pursuit acceleration; BRCA cis rs6598955 0.671 rs55791848 chr1:26582711 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.07 -0.56 4.09e-54 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg24562669 chr7:97807699 LMTK2 0.46 12.33 0.44 1.82e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.97 0.62 2.45e-69 Platelet count; BRCA cis rs6964587 0.626 rs6951795 chr7:91543764 T/C cg17063962 chr7:91808500 NA -0.56 -12.78 -0.45 1.77e-33 Breast cancer; BRCA cis rs6032067 0.598 rs2741500 chr20:43944958 G/T cg06407657 chr20:43937138 MATN4;RBPJL 0.31 8.34 0.31 4.5e-16 Blood protein levels; BRCA cis rs7923452 0.507 rs103441 chr10:30778184 C/T cg18806716 chr10:30721971 MAP3K8 -0.46 -10.74 -0.39 7.46e-25 Itch intensity from mosquito bite; BRCA cis rs9814567 1.000 rs934093 chr3:134195885 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.2 -0.6 3.27e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11644478 chr21:40555479 PSMG1 -0.5 -10.51 -0.38 6.37e-24 Menarche (age at onset); BRCA cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg06212747 chr3:49208901 KLHDC8B 0.48 9.75 0.36 4.9e-21 Parkinson's disease; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.63 -13.28 -0.47 9.89e-36 Lymphocyte counts; BRCA cis rs4722166 0.532 rs4719711 chr7:22755688 A/G cg05472934 chr7:22766657 IL6 -0.39 -9.74 -0.36 5.33e-21 Lung cancer; BRCA cis rs6582630 0.555 rs1906260 chr12:38601013 T/G cg13010199 chr12:38710504 ALG10B 0.52 10.58 0.39 3.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -18.09 -0.58 2.35e-59 Initial pursuit acceleration; BRCA cis rs4900538 0.855 rs9788420 chr14:102839338 A/G cg18135206 chr14:102964638 TECPR2 -0.93 -21.9 -0.65 1e-79 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.61 12.39 0.44 9.47e-32 Monocyte percentage of white cells; BRCA trans rs1005277 0.579 rs1780121 chr10:38529437 C/A cg17830980 chr10:43048298 ZNF37B -0.55 -13.31 -0.47 7.8e-36 Extrinsic epigenetic age acceleration; BRCA cis rs9393692 0.676 rs1543681 chr6:26187783 G/T cg00631329 chr6:26305371 NA -0.41 -11.24 -0.41 7.3e-27 Educational attainment; BRCA cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg22676075 chr6:135203613 NA 0.4 8.2 0.31 1.31e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7493 1.000 rs7493 chr7:95034775 C/G cg21856205 chr7:94953877 PON1 0.38 8.42 0.32 2.56e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs514406 0.505 rs431427 chr1:53179094 C/A cg08859206 chr1:53392774 SCP2 -0.42 -8.5 -0.32 1.29e-16 Monocyte count; BRCA trans rs6582630 0.502 rs2204008 chr12:38439203 C/T cg06521331 chr12:34319734 NA -0.43 -7.87 -0.3 1.56e-14 Drug-induced liver injury (flucloxacillin); BRCA cis rs17270561 0.608 rs4711102 chr6:25742075 T/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.4 -0.35 9.47e-20 Menopause (age at onset); BRCA cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg17143192 chr8:8559678 CLDN23 0.54 10.32 0.38 3.24e-23 Obesity-related traits; BRCA cis rs873946 0.504 rs4880275 chr10:134576552 C/T cg18305652 chr10:134549665 INPP5A 0.5 13.13 0.46 5.03e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4481887 0.927 rs4390209 chr1:248472613 A/T cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg11266682 chr4:10021025 SLC2A9 -0.41 -10.84 -0.39 3.08e-25 Bone mineral density; BRCA cis rs6582630 0.533 rs4103689 chr12:38702980 A/C cg26384229 chr12:38710491 ALG10B 0.54 13.72 0.48 1.01e-37 Drug-induced liver injury (flucloxacillin); BRCA cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg10523679 chr1:76189770 ACADM -0.45 -8.78 -0.33 1.49e-17 Daytime sleep phenotypes; BRCA cis rs72781680 1.000 rs12616250 chr2:24211550 T/C cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg24549020 chr5:56110836 MAP3K1 0.59 12.21 0.44 5.52e-31 Initial pursuit acceleration; BRCA cis rs514406 0.571 rs11206004 chr1:53210958 G/A cg25767906 chr1:53392781 SCP2 0.35 8.21 0.31 1.23e-15 Monocyte count; BRCA cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg26384229 chr12:38710491 ALG10B 0.77 17.43 0.57 5.93e-56 Bladder cancer; BRCA cis rs10416265 0.528 rs10420258 chr19:33602757 C/T cg17764715 chr19:33622953 WDR88 0.49 7.95 0.3 8.21e-15 Bone properties (heel); BRCA cis rs7945718 0.967 rs7930077 chr11:12778769 C/T cg25843174 chr11:12811716 TEAD1 0.22 8.6 0.32 5.97e-17 Educational attainment (years of education); BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg11814155 chr7:99998594 ZCWPW1 0.56 9.49 0.35 4.41e-20 Platelet count; BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg08067268 chr2:26466485 HADHB;HADHA -0.53 -9.79 -0.36 3.39e-21 Gut microbiome composition (summer); BRCA cis rs6912958 0.559 rs107689 chr6:88069333 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.37 10.78 0.39 5.34e-25 Monocyte percentage of white cells; BRCA cis rs2197308 0.692 rs7488528 chr12:37912971 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.35 0.54 1.76e-50 Morning vs. evening chronotype; BRCA cis rs11098499 0.780 rs12504773 chr4:120562149 G/C cg09307838 chr4:120376055 NA 0.67 13.49 0.47 1.12e-36 Corneal astigmatism; BRCA trans rs747782 0.527 rs7129364 chr11:48150576 G/A cg15704280 chr7:45808275 SEPT13 0.58 8.07 0.3 3.45e-15 Intraocular pressure; BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg08888203 chr3:10149979 C3orf24 0.55 11.7 0.42 8.97e-29 Alzheimer's disease; BRCA cis rs2070488 0.965 rs2366123 chr3:38493153 G/A cg24069376 chr3:38537580 EXOG 0.41 11.91 0.43 1.12e-29 Electrocardiographic conduction measures; BRCA cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.65 0.32 4.22e-17 Multiple sclerosis; BRCA cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg03477792 chr4:77819574 ANKRD56 0.65 15.66 0.53 4.98e-47 Emphysema distribution in smoking; BRCA cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg08975724 chr8:8085496 FLJ10661 -0.4 -8.34 -0.31 4.72e-16 Joint mobility (Beighton score); BRCA cis rs3125734 0.534 rs10821973 chr10:64052337 G/A cg19640130 chr10:64028056 RTKN2 -0.33 -9.05 -0.34 1.74e-18 Rheumatoid arthritis; BRCA cis rs6964587 0.900 rs6972027 chr7:91781380 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.01 0.3 5.35e-15 Breast cancer; BRCA cis rs7246657 0.882 rs10412043 chr19:37826626 A/C cg23950597 chr19:37808831 NA -0.62 -11.34 -0.41 2.68e-27 Coronary artery calcification; BRCA cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg22875332 chr1:76189707 ACADM 0.57 10.34 0.38 2.81e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs617791 0.508 rs2276132 chr11:65770545 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.48 8.78 0.33 1.48e-17 Breast cancer; BRCA cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg21132104 chr15:45694354 SPATA5L1 0.74 16.48 0.55 4.21e-51 Homoarginine levels; BRCA cis rs4919694 0.808 rs80020194 chr10:105035954 A/G cg04362960 chr10:104952993 NT5C2 0.82 10.97 0.4 9.18e-26 Arsenic metabolism; BRCA cis rs698833 0.892 rs786408 chr2:44733156 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.95 0.37 8.75e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg27170947 chr2:26402098 FAM59B 0.93 17.03 0.56 6.61e-54 Gut microbiome composition (summer); BRCA cis rs13191362 1.000 rs35723993 chr6:163008197 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13082711 0.554 rs1494422 chr3:27375190 T/C cg02860705 chr3:27208620 NA -0.56 -10.68 -0.39 1.28e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs4764124 0.646 rs10846062 chr12:14965781 T/C cg19759883 chr12:14956454 WBP11;C12orf60 0.5 11.62 0.42 1.84e-28 Pubertal anthropometrics; BRCA cis rs12986413 0.651 rs2238610 chr19:2146852 T/C cg09261902 chr19:2140048 AP3D1 0.43 11.05 0.4 4.35e-26 Height; BRCA cis rs17270561 0.636 rs9393656 chr6:25722059 A/C cg16482183 chr6:26056742 HIST1H1C 0.43 8.46 0.32 1.89e-16 Iron status biomarkers; BRCA cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg26647111 chr11:31128758 NA -0.45 -9.78 -0.36 3.99e-21 Red blood cell count; BRCA trans rs11088226 0.681 rs2833906 chr21:33945521 G/T cg09050820 chr6:167586206 TCP10L2 0.81 14.76 0.5 1.25e-42 Gastritis; BRCA cis rs7618915 0.547 rs13085331 chr3:52627486 G/C cg10802521 chr3:52805072 NEK4 -0.32 -8.3 -0.31 6.42e-16 Bipolar disorder; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.54 -11.33 -0.41 3.02e-27 Lymphocyte counts; BRCA cis rs68092024 0.704 rs704575 chr3:99486075 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.53 -0.38 5.12e-24 Cleft lip with or without cleft palate; BRCA trans rs6479891 1.000 rs9415692 chr10:65115152 G/A cg14819942 chr15:35414228 NA 0.34 8.35 0.31 4.37e-16 Arthritis (juvenile idiopathic); BRCA cis rs3741404 0.560 rs12362602 chr11:63908660 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.57 -12.67 -0.45 5.43e-33 Platelet count; BRCA cis rs1997103 1.000 rs6950311 chr7:55400990 G/A cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4363385 0.747 rs4845333 chr1:152982877 G/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs2806561 0.929 rs6660880 chr1:23540302 T/C cg12483005 chr1:23474871 LUZP1 -0.38 -8.29 -0.31 6.93e-16 Height; BRCA trans rs11098499 0.562 rs13101722 chr4:120555975 C/A cg25214090 chr10:38739885 LOC399744 -0.41 -9.27 -0.34 2.8e-19 Corneal astigmatism; BRCA cis rs6545883 0.831 rs2592356 chr2:61810428 G/C cg15711740 chr2:61764176 XPO1 -0.56 -14.36 -0.49 1.03e-40 Tuberculosis; BRCA cis rs10504073 0.647 rs10957357 chr8:49988587 C/A cg00325661 chr8:49890786 NA 0.42 11.96 0.43 6.72e-30 Blood metabolite ratios; BRCA cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.31 -0.44 2.18e-31 Chronic sinus infection; BRCA cis rs290268 0.817 rs291006 chr9:93540244 A/C cg02608019 chr9:93564028 SYK 0.48 10.08 0.37 2.89e-22 Platelet count; BRCA cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg23711669 chr6:146136114 FBXO30 -0.8 -19.34 -0.61 5.67e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs4589502 1.000 rs2414925 chr15:67129986 A/G cg09911534 chr15:67153556 NA -0.73 -9.7 -0.36 7.57e-21 Lung cancer (smoking interaction); BRCA cis rs2070997 0.816 rs6597642 chr9:133725767 C/T cg11464064 chr9:133710261 ABL1 0.53 8.76 0.33 1.75e-17 Response to amphetamines; BRCA trans rs4714291 0.832 rs1524087 chr6:40057504 A/G cg02267698 chr19:7991119 CTXN1 -0.45 -9.29 -0.34 2.42e-19 Strep throat; BRCA cis rs887829 0.569 rs4663963 chr2:234650193 T/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.39 -0.31 3.14e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs146671954 1 rs146671954 chr9:136934203 G/A cg13789015 chr9:136890014 NCRNA00094 0.57 8.92 0.33 4.73e-18 Red cell distribution width; BRCA cis rs8141529 0.748 rs6519766 chr22:29269991 A/G cg02153584 chr22:29168773 CCDC117 -0.52 -10.83 -0.39 3.18e-25 Lymphocyte counts; BRCA cis rs7572733 0.534 rs4369854 chr2:198800630 T/C cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.53e-21 Dermatomyositis; BRCA cis rs9790314 0.613 rs13092102 chr3:160598093 C/G cg03342759 chr3:160939853 NMD3 0.44 8.37 0.31 3.55e-16 Morning vs. evening chronotype; BRCA cis rs2576037 0.899 rs2571034 chr18:44578565 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 8.83 0.33 1.02e-17 Personality dimensions; BRCA cis rs9467711 0.591 rs3734528 chr6:26022244 A/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.22 0.34 4.11e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs708547 0.830 rs1713994 chr4:57868367 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -10.58 -0.39 3.14e-24 Response to bleomycin (chromatid breaks); BRCA cis rs2016266 0.819 rs7397757 chr12:53652684 A/G cg26875137 chr12:53738046 NA -0.37 -9.19 -0.34 5.33e-19 Bone mineral density (spine);Bone mineral density; BRCA cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg06627628 chr2:24431161 ITSN2 0.56 9.02 0.34 2.15e-18 Lymphocyte counts; BRCA cis rs7666738 0.716 rs11097615 chr4:99092773 T/C cg05340658 chr4:99064831 C4orf37 0.64 14.74 0.5 1.47e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg00106254 chr7:1943704 MAD1L1 -0.38 -9.81 -0.36 2.97e-21 Bipolar disorder and schizophrenia; BRCA cis rs4820539 0.902 rs4822359 chr22:23474972 A/G cg14186256 chr22:23484241 RTDR1 0.78 23.89 0.69 1.32e-90 Bone mineral density; BRCA cis rs2243480 1.000 rs4718316 chr7:65648731 A/G cg18252515 chr7:66147081 NA 1.06 16.03 0.54 7.81e-49 Diabetic kidney disease; BRCA trans rs11098499 0.820 rs2389885 chr4:120533931 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.02 0.3 5.03e-15 Corneal astigmatism; BRCA cis rs11190604 1.000 rs9420785 chr10:102240451 C/G cg07080220 chr10:102295463 HIF1AN 0.51 11.66 0.42 1.3e-28 Palmitoleic acid (16:1n-7) levels; BRCA cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg04673462 chr1:38461896 NA 0.45 10.37 0.38 2.21e-23 Coronary artery disease; BRCA cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg18132916 chr6:79620363 NA -0.4 -8.14 -0.31 2.11e-15 Intelligence (multi-trait analysis); BRCA cis rs6484504 0.532 rs7121949 chr11:31288160 G/T cg26647111 chr11:31128758 NA -0.45 -9.77 -0.36 4.28e-21 Red blood cell count; BRCA cis rs4820539 0.934 rs3788351 chr22:23469181 T/C cg14186256 chr22:23484241 RTDR1 0.76 22.49 0.66 6.07e-83 Bone mineral density; BRCA trans rs61931739 0.534 rs11053014 chr12:34103519 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.23 0.34 3.94e-19 Morning vs. evening chronotype; BRCA cis rs2832191 0.791 rs2832179 chr21:30480366 C/T cg08807101 chr21:30365312 RNF160 -0.6 -15.37 -0.52 1.35e-45 Dental caries; BRCA cis rs17001868 0.568 rs9611328 chr22:40791972 C/T cg07138101 chr22:40742427 ADSL 0.54 9.8 0.36 3.18e-21 Mammographic density (dense area); BRCA cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg02551604 chr5:131831745 NA -0.39 -14.62 -0.5 5.71e-42 Asthma (sex interaction); BRCA cis rs312273 0.573 rs11179173 chr12:41346762 A/G cg17827154 chr12:41323612 CNTN1 -0.42 -10.71 -0.39 1.01e-24 Bipolar disorder; BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg19010396 chr19:19431384 KIAA0892;SF4 0.48 9.51 0.35 3.76e-20 Tonsillectomy; BRCA cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.555 rs10880625 chr12:38526612 A/C cg13010199 chr12:38710504 ALG10B 0.53 10.73 0.39 8.42e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.42 -0.44 7.09e-32 Bipolar disorder; BRCA cis rs832540 0.629 rs3309 chr5:56092779 A/T cg20203395 chr5:56204925 C5orf35 0.35 7.93 0.3 1.01e-14 Coronary artery disease; BRCA cis rs12142240 0.698 rs112068407 chr1:46822291 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs34779708 0.931 rs10437420 chr10:35335044 A/C cg03585969 chr10:35415529 CREM -0.44 -9.29 -0.35 2.35e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg03452623 chr4:187889614 NA -0.34 -11.64 -0.42 1.53e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs7809950 1.000 rs2107713 chr7:107232369 C/T cg23024343 chr7:107201750 COG5 -0.37 -8.23 -0.31 1.05e-15 Coronary artery disease; BRCA cis rs867371 1.000 rs2867579 chr15:82475384 G/C cg00614314 chr15:82944287 LOC80154 0.43 9.09 0.34 1.21e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs34779708 0.733 rs7070778 chr10:35541688 T/C cg03585969 chr10:35415529 CREM 0.45 9.16 0.34 6.72e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6570726 0.967 rs413880 chr6:145804822 G/A cg23711669 chr6:146136114 FBXO30 0.63 14.29 0.49 2.19e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg24642439 chr20:33292090 TP53INP2 -0.53 -11.23 -0.41 7.69e-27 Glomerular filtration rate (creatinine); BRCA cis rs495337 0.760 rs2769978 chr20:48527423 A/G cg17835207 chr20:48524531 SPATA2 -0.69 -17.45 -0.57 4.93e-56 Psoriasis; BRCA cis rs1557765 0.527 rs4756887 chr11:17394597 T/G cg04705435 chr11:17411270 KCNJ11 0.34 7.88 0.3 1.38e-14 Body mass index;Social communication problems; BRCA cis rs68170813 0.559 rs2395880 chr7:107074264 A/G cg02696742 chr7:106810147 HBP1 -0.45 -7.87 -0.3 1.52e-14 Coronary artery disease; BRCA cis rs1577917 1.000 rs12204015 chr6:86598334 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.77 -0.42 4.47e-29 Response to antipsychotic treatment; BRCA cis rs2836974 0.644 rs2836986 chr21:40702136 A/C cg22974920 chr21:40686053 BRWD1 -0.41 -9.03 -0.34 1.96e-18 Cognitive function; BRCA cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg14844989 chr11:31128820 NA -0.45 -9.62 -0.36 1.51e-20 Red blood cell count; BRCA cis rs875971 1.000 rs2420820 chr7:66091907 T/C cg11764359 chr7:65958608 NA -0.78 -17.94 -0.58 1.29e-58 Aortic root size; BRCA cis rs2239547 0.618 rs4687663 chr3:52870618 T/A cg11645453 chr3:52864694 ITIH4 0.49 11.8 0.42 3.4e-29 Schizophrenia; BRCA cis rs12986413 0.967 rs1074047 chr19:2158748 A/G cg09261902 chr19:2140048 AP3D1 0.4 10.5 0.38 6.59e-24 Height; BRCA cis rs400736 0.602 rs7553544 chr1:8165719 C/T cg25007680 chr1:8021821 PARK7 -0.36 -8.19 -0.31 1.4e-15 Response to antidepressants and depression; BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg00814883 chr7:100076585 TSC22D4 -0.51 -11.67 -0.42 1.17e-28 Platelet count; BRCA cis rs13191362 1.000 rs34591938 chr6:163087003 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.62 9.88 0.36 1.66e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs870825 0.655 rs7683556 chr4:185632019 T/A cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg00677455 chr12:58241039 CTDSP2 0.71 16.12 0.54 2.69e-49 Intelligence (multi-trait analysis); BRCA cis rs61931739 0.553 rs68124042 chr12:34064431 C/A cg06521331 chr12:34319734 NA -0.62 -11.12 -0.4 2.15e-26 Morning vs. evening chronotype; BRCA cis rs317689 0.918 rs610192 chr12:69739941 T/C cg20891283 chr12:69753455 YEATS4 0.55 11.06 0.4 3.83e-26 Response to diuretic therapy; BRCA cis rs6912958 0.500 rs4707352 chr6:87929705 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.42 -11.91 -0.43 1.11e-29 Monocyte percentage of white cells; BRCA cis rs208520 1.000 rs72882079 chr6:66973878 T/C cg07460842 chr6:66804631 NA 0.88 14.2 0.49 5.86e-40 Exhaled nitric oxide output; BRCA cis rs6964587 1.000 rs7802788 chr7:91736874 A/G cg17063962 chr7:91808500 NA 0.59 14.06 0.49 2.62e-39 Breast cancer; BRCA cis rs11955398 0.604 rs4700379 chr5:59872392 G/A cg02684056 chr5:59996105 DEPDC1B 0.35 8.28 0.31 7.48e-16 Intelligence (multi-trait analysis); BRCA cis rs1113500 0.933 rs3893034 chr1:108632178 G/A cg06207961 chr1:108661230 NA 0.46 11.07 0.4 3.59e-26 Growth-regulated protein alpha levels; BRCA cis rs12681288 0.644 rs2123058 chr8:1000304 A/G cg04851639 chr8:1020857 NA -0.39 -11.11 -0.4 2.53e-26 Schizophrenia; BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.27 -0.46 1.11e-35 Platelet count; BRCA cis rs7640424 0.589 rs7612356 chr3:107811037 C/G cg09227934 chr3:107805635 CD47 -0.43 -8.11 -0.31 2.68e-15 Body mass index; BRCA cis rs9468199 0.505 rs72847381 chr6:27873931 G/A cg08851530 chr6:28072375 NA 0.8 8.24 0.31 1.01e-15 Parkinson's disease; BRCA cis rs12701220 0.689 rs12536282 chr7:1115650 C/T cg02733842 chr7:1102375 C7orf50 -0.86 -14.76 -0.5 1.23e-42 Bronchopulmonary dysplasia; BRCA cis rs7927771 0.524 rs2869024 chr11:47674101 G/A cg20307385 chr11:47447363 PSMC3 -0.42 -9.49 -0.35 4.68e-20 Subjective well-being; BRCA cis rs2153535 0.580 rs2327061 chr6:8447231 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.69e-23 Motion sickness; BRCA cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg08975724 chr8:8085496 FLJ10661 0.52 11.32 0.41 3.47e-27 Mood instability; BRCA cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg19077165 chr18:44547161 KATNAL2 0.55 12.2 0.43 6.37e-31 Personality dimensions; BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs1371614 0.545 rs3769138 chr2:27169540 G/T cg00617064 chr2:27272375 NA -0.31 -8.1 -0.31 2.75e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg13047869 chr3:10149882 C3orf24 0.6 12.07 0.43 2.33e-30 Alzheimer's disease; BRCA cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg05623727 chr3:50126028 RBM5 0.43 10.07 0.37 3.18e-22 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.810 rs7753531 chr6:79789996 A/C cg05283184 chr6:79620031 NA -0.39 -9.75 -0.36 4.96e-21 Intelligence (multi-trait analysis); BRCA cis rs7903847 0.642 rs11189191 chr10:99148796 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.25 -0.31 9.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg11166453 chr1:247681781 NA 0.45 9.92 0.37 1.19e-21 Acute lymphoblastic leukemia (childhood); BRCA cis rs17741873 0.836 rs17631059 chr10:75625558 G/C cg07699608 chr10:75541558 CHCHD1 0.55 8.4 0.32 2.78e-16 Paclitaxel disposition in epithelial ovarian cancer; BRCA trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.52 -0.32 1.16e-16 Extrinsic epigenetic age acceleration; BRCA cis rs9443645 0.527 rs1413969 chr6:79790982 A/G cg09184832 chr6:79620586 NA -0.44 -8.83 -0.33 9.68e-18 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.89 -0.33 6.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg14847009 chr1:175162515 KIAA0040 -0.25 -9.31 -0.35 1.99e-19 Alcohol dependence; BRCA cis rs2239547 0.563 rs4687560 chr3:52898121 T/G cg11645453 chr3:52864694 ITIH4 0.46 10.75 0.39 6.58e-25 Schizophrenia; BRCA trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.32 8.7 0.33 2.88e-17 Intelligence (multi-trait analysis); BRCA cis rs9297145 0.724 rs6958790 chr7:98774738 C/T cg05967295 chr7:98741636 SMURF1 -0.98 -18.54 -0.59 1.05e-61 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs13256369 0.901 rs4841015 chr8:8567140 C/G cg06671706 chr8:8559999 CLDN23 0.44 8.45 0.32 1.94e-16 Obesity-related traits; BRCA cis rs6964587 0.933 rs13230837 chr7:91779017 A/G cg22117172 chr7:91764530 CYP51A1 0.24 8.37 0.31 3.74e-16 Breast cancer; BRCA cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11890956 chr21:40555474 PSMG1 -0.65 -14.96 -0.51 1.4e-43 Menarche (age at onset); BRCA cis rs78707713 0.512 rs35793747 chr10:71182165 A/G cg12610070 chr10:71211762 TSPAN15 -0.32 -10.05 -0.37 3.76e-22 Venous thromboembolism; BRCA cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg03452623 chr4:187889614 NA 0.33 10.88 0.4 2.02e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg10523679 chr1:76189770 ACADM -0.61 -11.66 -0.42 1.34e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs847577 0.832 rs1799068 chr7:97707069 G/T cg21770322 chr7:97807741 LMTK2 -0.47 -12.9 -0.45 5.46e-34 Breast cancer; BRCA cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg07828340 chr4:882639 GAK 1.04 12.43 0.44 6.32e-32 Intelligence (multi-trait analysis); BRCA cis rs2624839 0.704 rs1046956 chr3:50222926 T/A cg05623727 chr3:50126028 RBM5 -0.38 -8.28 -0.31 7.29e-16 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs9814567 chr3:134218557 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.35 0.61 5.21e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs477692 0.673 rs579325 chr10:131363688 C/T cg24747557 chr10:131355152 MGMT -0.37 -8.84 -0.33 8.93e-18 Response to temozolomide; BRCA trans rs60843830 0.661 rs11674325 chr2:105517 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.48 9.36 0.35 1.35e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6840360 0.571 rs7678080 chr4:152557350 A/G cg22705602 chr4:152727874 NA -0.32 -8.38 -0.31 3.49e-16 Intelligence (multi-trait analysis); BRCA cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg11279151 chr3:101281821 RG9MTD1 -0.35 -7.88 -0.3 1.42e-14 Colorectal cancer; BRCA trans rs11098499 0.874 rs12502503 chr4:120116255 C/T cg25214090 chr10:38739885 LOC399744 0.51 10.46 0.38 9.9899999999999993e-24 Corneal astigmatism; BRCA cis rs4478858 0.698 rs11802155 chr1:31805012 T/C cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs4818225 0.804 rs9975388 chr21:42626362 C/A cg21268422 chr21:42620091 BACE2 0.46 8.73 0.33 2.24e-17 Educational attainment; BRCA cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg13770153 chr20:60521292 NA -0.78 -19.39 -0.61 3.4e-66 Obesity-related traits; BRCA cis rs8072100 0.935 rs78737171 chr17:45668760 A/T cg19784903 chr17:45786737 TBKBP1 0.34 8.09 0.3 3.05e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -7.85 -0.3 1.78e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs72480748 0.509 rs3865457 chr19:41398969 C/T cg09508736 chr19:41385865 CYP2A7 -0.45 -9.44 -0.35 6.86e-20 Post bronchodilator FEV1;Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); BRCA cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs12474201 0.775 rs7584870 chr2:46973400 A/T cg06386533 chr2:46925753 SOCS5 0.69 15.24 0.52 6.13e-45 Height; BRCA cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.82 0.36 2.67e-21 Bipolar disorder; BRCA trans rs6952808 0.630 rs1860832 chr7:2161849 G/A cg04565464 chr8:145669602 NFKBIL2 0.41 9.36 0.35 1.31e-19 Bipolar disorder and schizophrenia; BRCA cis rs1595825 0.891 rs16866980 chr2:198513009 A/C cg19156104 chr2:198669113 PLCL1 -0.43 -8.19 -0.31 1.41e-15 Ulcerative colitis; BRCA cis rs7394190 0.748 rs11000775 chr10:75539010 T/C cg07699608 chr10:75541558 CHCHD1 0.61 9.3 0.35 2.28e-19 Incident atrial fibrillation; BRCA cis rs7481584 0.581 rs105686 chr11:3062467 G/A cg08508325 chr11:3079039 CARS 0.28 8.63 0.32 5.01e-17 Calcium levels; BRCA trans rs561341 0.769 rs559228 chr17:30294527 T/C cg27661571 chr11:113659931 NA -0.7 -10.88 -0.4 2e-25 Hip circumference adjusted for BMI; BRCA cis rs13191362 0.507 rs1954806 chr6:163051858 G/C cg06582575 chr6:163149167 PACRG;PARK2 -0.49 -9.25 -0.34 3.32e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg26031613 chr14:104095156 KLC1 -0.48 -9.52 -0.35 3.54e-20 Schizophrenia; BRCA cis rs7592578 0.771 rs1128723 chr2:191366707 A/G cg11845111 chr2:191398756 TMEM194B -0.78 -14.78 -0.5 1.01e-42 Diastolic blood pressure; BRCA trans rs2270927 0.510 rs6453214 chr5:75584423 A/G cg13563193 chr19:33072644 PDCD5 0.86 10.09 0.37 2.51e-22 Mean corpuscular volume; BRCA cis rs681343 1.000 rs516316 chr19:49206145 C/G cg21064579 chr19:49206444 FUT2 0.37 9.12 0.34 9.49e-19 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs2576037 0.583 rs4890343 chr18:44540969 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -11.52 -0.41 4.89e-28 Personality dimensions; BRCA cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg16339924 chr4:17578868 LAP3 -0.58 -13.53 -0.47 7.28e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg11279151 chr3:101281821 RG9MTD1 -0.34 -7.87 -0.3 1.48e-14 Colorectal cancer; BRCA cis rs2282526 0.615 rs162377 chr21:44926001 A/G cg01579765 chr21:45077557 HSF2BP -0.36 -8.68 -0.32 3.21e-17 Mean corpuscular hemoglobin; BRCA cis rs9858542 0.953 rs9821311 chr3:49543656 C/T cg03060546 chr3:49711283 APEH -0.54 -10.99 -0.4 7.38e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6963495 0.592 rs114793754 chr7:105152162 G/C cg13798780 chr7:105162888 PUS7 0.45 7.9 0.3 1.21e-14 Bipolar disorder (body mass index interaction); BRCA cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg26769984 chr7:1090371 C7orf50 0.64 11.44 0.41 1.08e-27 Bronchopulmonary dysplasia; BRCA cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg05347473 chr6:146136440 FBXO30 0.41 7.97 0.3 7.53e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9287719 0.649 rs12104950 chr2:10732105 G/A cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg16405210 chr4:1374714 KIAA1530 -0.93 -21.48 -0.65 1.86e-77 Longevity; BRCA cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg08392591 chr16:89556376 ANKRD11 0.47 11.17 0.4 1.32e-26 Multiple myeloma (IgH translocation); BRCA cis rs10654220 1 rs10654220 chr12:123703422 A/AGTT cg00376283 chr12:123451042 ABCB9 0.51 9.98 0.37 6.87e-22 Platelet count; BRCA cis rs6740322 0.748 rs13432574 chr2:43544328 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.68 -12.54 -0.44 2.19e-32 Coronary artery disease; BRCA cis rs736408 0.736 rs4687550 chr3:52823430 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.31 0.31 5.64e-16 Bipolar disorder; BRCA cis rs17270561 0.666 rs1141034 chr6:25780332 C/T cg16482183 chr6:26056742 HIST1H1C 0.51 9.99 0.37 6.26e-22 Iron status biomarkers; BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.42 8.41 0.32 2.6e-16 Tonsillectomy; BRCA cis rs17401966 0.838 rs12127604 chr1:10352800 T/G cg03954927 chr1:10346856 KIF1B 0.43 13.7 0.48 1.24e-37 Hepatocellular carcinoma; BRCA cis rs875971 0.830 rs28714531 chr7:65968237 G/A cg18876405 chr7:65276391 NA 0.5 11.1 0.4 2.63e-26 Aortic root size; BRCA cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg08975724 chr8:8085496 FLJ10661 0.46 10.04 0.37 4.02e-22 Mood instability; BRCA cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg13628971 chr7:2884303 GNA12 0.37 7.98 0.3 6.87e-15 Height; BRCA cis rs9467773 0.549 rs9461273 chr6:26584526 A/G cg09904177 chr6:26538194 HMGN4 -0.43 -13.65 -0.48 2.01e-37 Intelligence (multi-trait analysis); BRCA cis rs17095355 0.892 rs7085888 chr10:111713930 A/G cg00817464 chr10:111662876 XPNPEP1 0.34 8.48 0.32 1.62e-16 Biliary atresia; BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.98 -0.3 6.61e-15 Total body bone mineral density; BRCA cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg08601574 chr20:25228251 PYGB -0.34 -8.12 -0.31 2.42e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.72 0.45 3.26e-33 Mean platelet volume; BRCA cis rs13102973 0.965 rs4864240 chr4:135856737 T/C cg14419869 chr4:135874104 NA -0.59 -13.08 -0.46 8.68e-35 Subjective well-being; BRCA cis rs11971779 0.680 rs6962366 chr7:139043867 G/A cg07862535 chr7:139043722 LUC7L2 0.38 10.37 0.38 2.13e-23 Diisocyanate-induced asthma; BRCA cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg11663144 chr21:46675770 NA -0.54 -12.7 -0.45 4.17e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 17.94 0.58 1.42e-58 Platelet count; BRCA cis rs6545883 0.894 rs778143 chr2:61581890 A/C cg15711740 chr2:61764176 XPO1 -0.5 -12.07 -0.43 2.43e-30 Tuberculosis; BRCA cis rs2479724 0.868 rs2249703 chr6:41814760 A/G cg17623882 chr6:41773611 USP49 -0.36 -9.76 -0.36 4.53e-21 Menarche (age at onset); BRCA cis rs13191362 1.000 rs55847707 chr6:163003414 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs62229266 0.804 rs998383 chr21:37445739 C/G cg12218747 chr21:37451666 NA -0.38 -8.9 -0.33 5.83e-18 Mitral valve prolapse; BRCA cis rs427394 0.664 rs274697 chr5:6731477 A/C cg10857441 chr5:6722123 POLS -0.32 -10.9 -0.4 1.66e-25 Menopause (age at onset); BRCA trans rs2270927 0.510 rs2358712 chr5:75580687 A/G cg13563193 chr19:33072644 PDCD5 0.86 10.12 0.37 2.01e-22 Mean corpuscular volume; BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg27170947 chr2:26402098 FAM59B -0.81 -13.08 -0.46 7.88e-35 Gut microbiome composition (summer); BRCA cis rs6910061 1.000 rs9468436 chr6:11112626 C/G cg27233058 chr6:11094804 LOC221710 0.53 9.51 0.35 3.79e-20 Diabetic kidney disease; BRCA cis rs7666738 0.830 rs7674095 chr4:99048158 T/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg12000995 chr2:27665139 KRTCAP3 0.34 8.54 0.32 9.62e-17 Total body bone mineral density; BRCA cis rs11676348 0.818 rs6436033 chr2:218983763 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.4 -8.45 -0.32 1.92e-16 Ulcerative colitis; BRCA trans rs57221529 0.766 rs4081847 chr5:574072 C/T cg11887960 chr12:57824829 NA 0.51 8.34 0.31 4.57e-16 Lung disease severity in cystic fibrosis; BRCA cis rs6831352 0.879 rs29001196 chr4:100054116 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs7560272 0.538 rs4241257 chr2:73938607 T/C cg20560298 chr2:73613845 ALMS1 0.33 8.58 0.32 7.16e-17 Schizophrenia; BRCA cis rs9399135 0.967 rs4896119 chr6:135293391 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.4 0.44 8.41e-32 Red blood cell count; BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26314531 chr2:26401878 FAM59B -0.66 -11.2 -0.4 1.08e-26 Gut microbiome composition (summer); BRCA cis rs477692 0.673 rs511361 chr10:131365052 C/T cg05714579 chr10:131428358 MGMT 0.51 11.09 0.4 2.81e-26 Response to temozolomide; BRCA trans rs9858542 0.953 rs9862080 chr3:49674458 A/G cg21659725 chr3:3221576 CRBN -0.49 -10.57 -0.39 3.56e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4805272 0.626 rs12608533 chr19:29331405 C/G cg12756686 chr19:29218302 NA 0.38 8.04 0.3 4.42e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg07917127 chr4:99064746 C4orf37 0.39 7.85 0.3 1.79e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.65 -11.59 -0.42 2.59e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9790314 0.580 rs10936227 chr3:161043869 A/C cg04691961 chr3:161091175 C3orf57 -0.39 -9.12 -0.34 1e-18 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs4515155 chr4:17696477 G/T cg02297831 chr4:17616191 MED28 0.36 8.52 0.32 1.17e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11644478 chr21:40555479 PSMG1 -0.5 -10.7 -0.39 1.04e-24 Menarche (age at onset); BRCA cis rs4819052 0.788 rs35323494 chr21:46703739 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.59 12.23 0.44 4.51e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg21017887 chr14:105400489 NA -0.63 -16.17 -0.54 1.51e-49 Rheumatoid arthritis; BRCA cis rs1883415 0.534 rs2760149 chr6:24477848 C/T cg20631270 chr6:24437470 GPLD1 0.4 8.17 0.31 1.6e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10267417 0.535 rs10242331 chr7:19923552 T/C cg05791153 chr7:19748676 TWISTNB 0.43 7.95 0.3 8.6e-15 Night sleep phenotypes; BRCA trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.06e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs17216711 chr8:58170856 T/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs2415984 0.622 rs2817568 chr14:46940986 C/G cg14871534 chr14:47121158 RPL10L 0.32 8.08 0.3 3.18e-15 Number of children ever born; BRCA cis rs250677 0.522 rs1007400 chr5:148382635 C/T cg12140854 chr5:148520817 ABLIM3 0.42 8.55 0.32 9.35e-17 Breast cancer; BRCA cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24531977 chr5:56204891 C5orf35 0.87 18.56 0.59 8.17e-62 Initial pursuit acceleration; BRCA cis rs6121246 0.909 rs6060633 chr20:30263317 G/T cg21427119 chr20:30132790 HM13 -0.42 -8.92 -0.33 4.92e-18 Mean corpuscular hemoglobin; BRCA cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.8 -0.33 1.3e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg12419862 chr22:24373484 LOC391322 0.62 13.26 0.46 1.29e-35 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs854765 0.547 rs9896837 chr17:17924868 A/G cg04398451 chr17:18023971 MYO15A -0.66 -14.46 -0.5 3.37e-41 Total body bone mineral density; BRCA cis rs10751667 1.000 rs6597965 chr11:964476 A/G cg01483505 chr11:975446 AP2A2 0.34 9.09 0.34 1.28e-18 Alzheimer's disease (late onset); BRCA cis rs17270561 0.609 rs9358871 chr6:25726675 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs3008870 1.000 rs2985822 chr1:67404910 T/G cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.48 0.65 1.77e-77 Lymphocyte percentage of white cells; BRCA cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.33 0.68 1.52e-87 Chronic sinus infection; BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg20607798 chr8:58055168 NA 0.65 10.01 0.37 5.05e-22 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.889 rs2211080 chr1:76243438 G/A cg22875332 chr1:76189707 ACADM 0.66 13.85 0.48 2.36e-38 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs7980799 0.649 rs11052736 chr12:33669583 T/C cg26384229 chr12:38710491 ALG10B 0.52 10.89 0.4 1.81e-25 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs1707322 1.000 rs11211217 chr1:46348229 C/G cg03146154 chr1:46216737 IPP 0.45 9.95 0.37 8.9e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7903847 0.642 rs10882910 chr10:99138043 G/A cg20016023 chr10:99160130 RRP12 -0.27 -8.59 -0.32 6.67e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2455799 0.573 rs924753 chr3:15706124 C/T cg16303742 chr3:15540471 COLQ -0.38 -9.19 -0.34 5.57e-19 Mean platelet volume; BRCA cis rs7917772 0.582 rs10748826 chr10:104354804 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs936229 0.861 rs7180484 chr15:75115416 G/T cg14664628 chr15:75095509 CSK 0.94 28.94 0.75 2.65e-118 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6831352 0.918 rs34876213 chr4:100062216 G/A cg12011299 chr4:100065546 ADH4 -0.52 -11.93 -0.43 8.89e-30 Alcohol dependence; BRCA cis rs796364 0.806 rs74724807 chr2:201005109 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA cis rs2832077 0.943 rs2832100 chr21:30175628 A/C cg08807101 chr21:30365312 RNF160 -0.45 -7.9 -0.3 1.22e-14 Cognitive test performance; BRCA cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg20573242 chr4:122745356 CCNA2 0.49 10.99 0.4 7.79e-26 Type 2 diabetes; BRCA cis rs7178424 1.000 rs34096515 chr15:62379449 T/C cg00456672 chr15:62358751 C2CD4A -0.34 -8.22 -0.31 1.11e-15 Height; BRCA cis rs7264396 0.563 rs11906854 chr20:34383634 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -11.02 -0.4 5.55e-26 Total cholesterol levels; BRCA cis rs11190604 1.000 rs2295776 chr10:102295629 G/T cg07080220 chr10:102295463 HIF1AN 0.63 14.98 0.51 1.08e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs7772486 0.686 rs2142983 chr6:146069701 G/C cg05347473 chr6:146136440 FBXO30 -0.39 -7.87 -0.3 1.57e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs943466 0.956 rs1075379 chr6:33737800 T/C cg25922239 chr6:33757077 LEMD2 -0.38 -8.29 -0.31 6.5e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.11 -0.34 1.04e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg08601574 chr20:25228251 PYGB -0.39 -9.0 -0.34 2.64e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 0.648 rs4439382 chr1:46150805 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.88e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.72 0.36 6.36e-21 Menopause (age at onset); BRCA cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg08219700 chr8:58056026 NA 0.44 7.94 0.3 8.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs2712184 0.687 rs62180470 chr2:217645451 A/G cg05032264 chr2:217675019 NA 0.34 8.06 0.3 3.8e-15 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs4363385 0.818 rs2152994 chr1:152991060 C/T cg24667326 chr1:152973720 SPRR3 0.3 8.49 0.32 1.45e-16 Inflammatory skin disease; BRCA cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg16339924 chr4:17578868 LAP3 0.56 13.86 0.48 2.31e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs858239 0.539 rs3950345 chr7:23191114 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs12971120 1.000 rs2278161 chr18:72176083 T/C cg26446133 chr18:72167187 CNDP2 -0.75 -14.45 -0.5 3.78e-41 Refractive error; BRCA cis rs11105298 0.891 rs10777185 chr12:89921275 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -9.27 -0.34 2.92e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs870825 0.655 rs2017101 chr4:185637381 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA trans rs1997103 1.000 rs2140915 chr7:55410699 G/C cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg22903471 chr2:27725779 GCKR -0.37 -9.03 -0.34 1.96e-18 Total body bone mineral density; BRCA cis rs12477438 0.765 rs6754843 chr2:99680485 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg17063962 chr7:91808500 NA 0.54 12.84 0.45 9.87e-34 Breast cancer; BRCA cis rs12711979 0.509 rs10195596 chr2:3824222 T/G cg17052675 chr2:3827356 NA -0.7 -23.65 -0.68 2.6e-89 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs7267979 1.000 rs4815418 chr20:25382211 T/G cg08601574 chr20:25228251 PYGB -0.34 -8.12 -0.31 2.45e-15 Liver enzyme levels (alkaline phosphatase); BRCA trans rs7939886 0.841 rs11231800 chr11:55770930 A/G cg03929089 chr4:120376271 NA 0.69 8.01 0.3 5.46e-15 Myopia (pathological); BRCA cis rs6089584 0.566 rs2146852 chr20:60616492 T/G cg06108461 chr20:60628389 TAF4 -0.72 -15.25 -0.52 4.92e-45 Body mass index; BRCA cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11890956 chr21:40555474 PSMG1 0.97 22.36 0.66 3.2e-82 Cognitive function; BRCA cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg09184832 chr6:79620586 NA -0.48 -10.63 -0.39 2.12e-24 Intelligence (multi-trait analysis); BRCA cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg10664184 chr19:17420304 DDA1 0.36 10.24 0.38 6.85e-23 Systemic lupus erythematosus; BRCA cis rs9733 0.519 rs1134067 chr1:150721175 G/T cg04414720 chr1:150670196 GOLPH3L 0.36 7.96 0.3 7.96e-15 Tonsillectomy; BRCA cis rs1153858 1.000 rs4774577 chr15:45644685 A/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg00166722 chr3:10149974 C3orf24 0.57 11.34 0.41 2.89e-27 Alzheimer's disease; BRCA cis rs7264396 0.561 rs6060753 chr20:34598430 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.5 -9.42 -0.35 7.86e-20 Total cholesterol levels; BRCA trans rs11039798 0.688 rs12277029 chr11:48852833 G/T cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs9393692 0.905 rs6940237 chr6:26282322 T/C cg00631329 chr6:26305371 NA -0.42 -12.61 -0.45 1.07e-32 Educational attainment; BRCA cis rs6815814 0.950 rs5743556 chr4:38806851 A/G cg06935464 chr4:38784597 TLR10 0.51 8.42 0.32 2.52e-16 Breast cancer; BRCA cis rs875971 1.000 rs2087647 chr7:65593188 C/A cg18876405 chr7:65276391 NA -0.56 -13.35 -0.47 5.16e-36 Aortic root size; BRCA cis rs11190604 1.000 rs2495752 chr10:102326115 T/C cg07080220 chr10:102295463 HIF1AN 0.64 14.96 0.51 1.32e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs11585357 0.947 rs6666990 chr1:17611520 G/A cg19159961 chr1:17633534 PADI4 -0.49 -8.76 -0.33 1.69e-17 Hair shape; BRCA trans rs1493916 1.000 rs12457802 chr18:31389865 A/G cg15819921 chr19:927150 ARID3A 0.45 8.51 0.32 1.22e-16 Life satisfaction; BRCA cis rs7927592 0.546 rs638076 chr11:68202580 A/G cg01657329 chr11:68192670 LRP5 -0.39 -9.78 -0.36 3.82e-21 Total body bone mineral density; BRCA cis rs4689388 0.926 rs4689391 chr4:6280449 G/A cg25554036 chr4:6271136 WFS1 0.42 10.16 0.37 1.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7586879 0.828 rs9631062 chr2:25110084 C/T cg04586622 chr2:25135609 ADCY3 0.39 9.36 0.35 1.37e-19 Body mass index; BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg22920501 chr2:26401640 FAM59B -0.9 -16.11 -0.54 3.04e-49 Gut microbiome composition (summer); BRCA cis rs6430585 0.583 rs6728946 chr2:136635343 C/G cg07169764 chr2:136633963 MCM6 1.28 29.33 0.76 2.04e-120 Corneal structure; BRCA cis rs9467773 1.000 rs9467787 chr6:26556769 G/T cg09904177 chr6:26538194 HMGN4 0.55 17.61 0.57 7.14e-57 Intelligence (multi-trait analysis); BRCA cis rs4588572 0.643 rs1864173 chr5:77691158 C/T cg11547950 chr5:77652471 NA 0.44 7.81 0.3 2.35e-14 Triglycerides; BRCA trans rs4332037 0.707 rs62435130 chr7:1890002 C/T cg11693508 chr17:37793320 STARD3 0.61 11.25 0.41 6.75e-27 Bipolar disorder; BRCA cis rs57221529 0.766 rs58015612 chr5:580665 A/T cg20362242 chr5:692897 TPPP 0.53 8.0 0.3 5.8e-15 Lung disease severity in cystic fibrosis; BRCA trans rs9291683 0.632 rs10939669 chr4:10045827 A/G cg26043149 chr18:55253948 FECH 0.43 9.29 0.34 2.32e-19 Bone mineral density; BRCA cis rs7833986 0.501 rs72653967 chr8:56999432 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.99 0.46 2.13e-34 Height; BRCA cis rs2762353 0.595 rs12200838 chr6:25753603 C/T cg03517284 chr6:25882590 NA 0.69 16.0 0.53 1.06e-48 Blood metabolite levels; BRCA cis rs9880211 0.752 rs9847427 chr3:136351550 C/A cg21827317 chr3:136751795 NA -0.45 -7.93 -0.3 1.01e-14 Body mass index;Height; BRCA cis rs6973256 0.828 rs12707117 chr7:133429058 G/A cg07491979 chr7:133331646 EXOC4 0.36 8.36 0.31 3.8e-16 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.863 rs11723090 chr4:120490592 T/C cg09307838 chr4:120376055 NA 0.69 13.84 0.48 2.79e-38 Corneal astigmatism; BRCA cis rs2425143 1.000 rs8115150 chr20:34397189 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.53 -0.32 1.09e-16 Blood protein levels; BRCA cis rs11971779 0.793 rs9632774 chr7:139137562 C/T cg07862535 chr7:139043722 LUC7L2 0.37 9.11 0.34 1.03e-18 Diisocyanate-induced asthma; BRCA cis rs61931739 0.534 rs814669 chr12:34102459 C/T cg06521331 chr12:34319734 NA -0.62 -12.2 -0.43 6.08e-31 Morning vs. evening chronotype; BRCA cis rs262150 0.837 rs2657404 chr7:158783155 C/T cg19418458 chr7:158789849 NA -0.41 -9.29 -0.34 2.44e-19 Facial morphology (factor 20); BRCA cis rs11051970 0.879 rs1500874 chr12:32589407 G/A cg02745156 chr12:32552066 NA 0.27 8.86 0.33 7.83e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11971779 0.938 rs11981688 chr7:139088895 A/G cg07862535 chr7:139043722 LUC7L2 0.51 12.72 0.45 3.24e-33 Diisocyanate-induced asthma; BRCA trans rs6582630 0.502 rs7311700 chr12:38463232 T/A cg06521331 chr12:34319734 NA -0.51 -9.24 -0.34 3.5e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs832540 0.695 rs702686 chr5:56201350 A/G cg12311346 chr5:56204834 C5orf35 -0.56 -11.82 -0.42 2.74e-29 Coronary artery disease; BRCA cis rs3093024 0.839 rs968334 chr6:167526096 T/C cg07741184 chr6:167504864 NA -0.28 -8.36 -0.31 3.78e-16 Rheumatoid arthritis; BRCA cis rs6430585 1.000 rs6430585 chr2:136506927 A/C cg07169764 chr2:136633963 MCM6 -0.95 -20.19 -0.62 1.78e-70 Corneal structure; BRCA cis rs3741404 0.825 rs2515241 chr11:63975331 C/T cg18225595 chr11:63971243 STIP1 0.52 13.01 0.46 1.67e-34 Platelet count; BRCA cis rs10782582 0.593 rs12131344 chr1:76136437 C/T cg10523679 chr1:76189770 ACADM -0.46 -8.73 -0.33 2.29e-17 Daytime sleep phenotypes; BRCA cis rs9486715 0.830 rs1475748 chr6:97034143 T/C cg06623918 chr6:96969491 KIAA0776 -0.92 -26.72 -0.73 3.64e-106 Headache; BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26314531 chr2:26401878 FAM59B -0.69 -11.53 -0.41 4.68e-28 Gut microbiome composition (summer); BRCA cis rs2505998 0.833 rs2742243 chr10:43601749 T/C cg15436174 chr10:43711423 RASGEF1A -0.39 -7.98 -0.3 6.97e-15 Hirschsprung disease; BRCA cis rs3806843 0.648 rs702399 chr5:140024432 C/T cg16179182 chr5:140090404 VTRNA1-1 0.45 10.36 0.38 2.35e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg12756686 chr19:29218302 NA 0.46 8.16 0.31 1.79e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg11301795 chr4:187892539 NA -0.26 -8.5 -0.32 1.33e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9435341 0.965 rs1762485 chr1:107625056 C/T cg09367891 chr1:107599246 PRMT6 -0.55 -9.93 -0.37 1.01e-21 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg18225595 chr11:63971243 STIP1 0.53 9.6 0.36 1.73e-20 Mean platelet volume; BRCA cis rs9612 1.000 rs28446957 chr19:44246600 T/A cg08581076 chr19:44259116 C19orf61 0.53 9.19 0.34 5.46e-19 Exhaled nitric oxide output; BRCA cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg03676636 chr4:99064102 C4orf37 0.23 7.88 0.3 1.38e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg14004847 chr7:1930337 MAD1L1 -0.45 -8.56 -0.32 8.67e-17 Bipolar disorder and schizophrenia; BRCA cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg00339695 chr16:24857497 SLC5A11 0.48 9.72 0.36 6.25e-21 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.874 rs13393902 chr2:227880554 A/G cg11843606 chr2:227700838 RHBDD1 -0.36 -8.03 -0.3 4.57e-15 Pulmonary function; BRCA cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg06784218 chr1:46089804 CCDC17 0.46 11.02 0.4 5.46e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -8.75 -0.33 1.82e-17 Neuroticism; BRCA cis rs9986765 1.000 rs9986765 chr7:142835239 C/T cg22531018 chr7:142981779 TMEM139 -0.57 -9.72 -0.36 6.41e-21 Cancer;Dermatomyositis; BRCA cis rs11098499 0.754 rs9991959 chr4:120253773 C/T cg09307838 chr4:120376055 NA -0.63 -13.7 -0.48 1.22e-37 Corneal astigmatism; BRCA cis rs708547 0.874 rs1630798 chr4:57883558 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.51 12.22 0.44 5.35e-31 Response to bleomycin (chromatid breaks); BRCA cis rs6450176 0.638 rs3822497 chr5:53299693 C/G cg22592108 chr5:53304441 ARL15 0.31 7.83 0.3 2.04e-14 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs2204008 0.715 rs11514342 chr12:38236710 T/A cg06521331 chr12:34319734 NA -0.5 -9.14 -0.34 8.28e-19 Bladder cancer; BRCA cis rs7772486 0.846 rs9403767 chr6:146402386 G/T cg13319975 chr6:146136371 FBXO30 -0.38 -8.37 -0.31 3.77e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs67478160 0.619 rs12885018 chr14:104273812 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.16 -0.4 1.56e-26 Schizophrenia; BRCA cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg13319975 chr6:146136371 FBXO30 0.62 14.38 0.49 8.08e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs921968 0.643 rs589967 chr2:219445165 T/C cg02176678 chr2:219576539 TTLL4 0.4 10.88 0.4 2.09e-25 Mean corpuscular hemoglobin concentration; BRCA trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg03929089 chr4:120376271 NA -0.47 -9.04 -0.34 1.9e-18 HDL cholesterol; BRCA cis rs9487051 0.768 rs458185 chr6:109524074 A/G cg01475377 chr6:109611718 NA -0.44 -11.24 -0.41 7.33e-27 Reticulocyte fraction of red cells; BRCA cis rs6669008 1.000 rs1891969 chr1:114185855 C/A cg26035817 chr1:114414802 PTPN22 0.35 8.57 0.32 7.83e-17 Bacteremia; BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg08888203 chr3:10149979 C3orf24 0.68 14.48 0.5 2.55e-41 Alzheimer's disease; BRCA cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24531977 chr5:56204891 C5orf35 -0.8 -16.12 -0.54 2.66e-49 Initial pursuit acceleration; BRCA trans rs2797160 1.000 rs1739378 chr6:126012262 C/A cg05039488 chr6:79577232 IRAK1BP1 0.35 7.91 0.3 1.11e-14 Endometrial cancer; BRCA cis rs7772486 0.875 rs7766595 chr6:146364507 A/T cg23711669 chr6:146136114 FBXO30 0.69 16.02 0.54 7.97e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg00750074 chr16:89608354 SPG7 -0.38 -10.25 -0.38 6.4e-23 Multiple myeloma (IgH translocation); BRCA cis rs7178424 0.869 rs3784634 chr15:62259637 C/T cg00456672 chr15:62358751 C2CD4A 0.42 9.42 0.35 7.78e-20 Height; BRCA trans rs9858542 0.953 rs6446272 chr3:49463287 G/A cg21659725 chr3:3221576 CRBN -0.46 -9.86 -0.36 1.94e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2882667 0.858 rs11959851 chr5:138421405 C/G cg04439458 chr5:138467593 SIL1 -0.39 -10.51 -0.38 5.9e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs586533 0.881 rs593946 chr11:99498370 C/A cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs2274273 1.000 rs7160110 chr14:55594635 A/G cg04306507 chr14:55594613 LGALS3 0.33 9.14 0.34 8.1e-19 Protein biomarker; BRCA cis rs3768617 0.510 rs10797849 chr1:183088988 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.18 0.54 1.35e-49 Fuchs's corneal dystrophy; BRCA cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg12011299 chr4:100065546 ADH4 0.53 12.86 0.45 7.62e-34 Alcohol dependence; BRCA cis rs7267979 0.899 rs442834 chr20:25458096 A/G cg08601574 chr20:25228251 PYGB 0.35 8.37 0.31 3.62e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg24692254 chr21:30365293 RNF160 -0.6 -15.11 -0.51 2.49e-44 Dental caries; BRCA cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg08885076 chr2:99613938 TSGA10 0.43 10.31 0.38 3.72e-23 Chronic sinus infection; BRCA cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs919433 0.617 rs4850436 chr2:198541398 C/T cg00792783 chr2:198669748 PLCL1 -0.43 -9.53 -0.35 3.25e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10791323 0.546 rs55801927 chr11:133713094 A/C cg15485101 chr11:133734466 NA 0.4 9.77 0.36 4.32e-21 Childhood ear infection; BRCA cis rs847577 0.588 rs6946915 chr7:97711340 C/G cg21770322 chr7:97807741 LMTK2 0.61 17.63 0.57 5.22e-57 Breast cancer; BRCA cis rs2479724 0.905 rs2251274 chr6:41839438 T/G cg17623882 chr6:41773611 USP49 -0.38 -10.28 -0.38 4.85e-23 Menarche (age at onset); BRCA cis rs4819052 0.885 rs9980676 chr21:46665430 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.97 0.37 7.69e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2625529 0.824 rs11072339 chr15:72247190 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.27 -0.56 3.79e-55 Red blood cell count; BRCA cis rs7818345 0.967 rs11784873 chr8:19281113 A/G cg11303988 chr8:19266685 CSGALNACT1 0.31 8.25 0.31 8.78e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs12493885 0.818 rs73160504 chr3:153773384 C/T cg17054900 chr3:154042577 DHX36 -0.5 -8.65 -0.32 4.07e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2072499 0.966 rs11587860 chr1:156156951 G/C cg24450063 chr1:156163899 SLC25A44 1.09 34.22 0.8 1.34e-146 Testicular germ cell tumor; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg23978390 chr7:1156363 C7orf50 0.39 7.97 0.3 7.14e-15 Bronchopulmonary dysplasia; BRCA cis rs45509595 0.841 rs200485 chr6:27775697 G/C cg26587870 chr6:27730563 NA -0.51 -7.91 -0.3 1.12e-14 Breast cancer; BRCA cis rs7980687 0.638 rs7299943 chr12:123593485 A/T cg00376283 chr12:123451042 ABCB9 0.45 9.82 0.36 2.69e-21 Height;Educational attainment;Head circumference (infant); BRCA cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg21770322 chr7:97807741 LMTK2 0.41 10.7 0.39 1.11e-24 Prostate cancer (SNP x SNP interaction); BRCA cis rs1865760 0.892 rs6456705 chr6:25936056 G/A cg16482183 chr6:26056742 HIST1H1C 0.51 10.41 0.38 1.45e-23 Height; BRCA cis rs9487051 0.872 rs9480923 chr6:109607369 G/C cg21918786 chr6:109611834 NA -0.49 -14.13 -0.49 1.18e-39 Reticulocyte fraction of red cells; BRCA cis rs8180040 0.620 rs6442055 chr3:47110722 A/G cg16586182 chr3:47516702 SCAP -0.57 -12.47 -0.44 4.09e-32 Colorectal cancer; BRCA cis rs12142240 0.698 rs67941619 chr1:46838219 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.44 -0.35 7.1e-20 Menopause (age at onset); BRCA cis rs9290065 0.585 rs716779 chr3:160645428 G/A cg03342759 chr3:160939853 NMD3 0.41 8.41 0.32 2.64e-16 Kawasaki disease; BRCA cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg23029597 chr12:123009494 RSRC2 -0.47 -9.8 -0.36 3.23e-21 Body mass index; BRCA cis rs9291683 0.546 rs13139055 chr4:10038924 G/T cg00071950 chr4:10020882 SLC2A9 0.55 13.35 0.47 5.05e-36 Bone mineral density; BRCA cis rs2304069 0.779 rs245081 chr5:149356075 G/T cg12661370 chr5:149340060 SLC26A2 0.58 10.25 0.38 6.37e-23 HIV-1 control; BRCA cis rs9733 0.596 rs72702523 chr1:150650425 G/T cg18016565 chr1:150552671 MCL1 0.35 8.2 0.31 1.3e-15 Tonsillectomy; BRCA trans rs11098499 0.909 rs10002083 chr4:120311152 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs10504229 1.000 rs17216620 chr8:58169412 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.64 -0.32 4.36e-17 Developmental language disorder (linguistic errors); BRCA cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg11645453 chr3:52864694 ITIH4 0.47 11.31 0.41 3.56e-27 Schizophrenia; BRCA cis rs11690935 0.959 rs10204622 chr2:172588982 C/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.46 -0.77 1.51e-126 Schizophrenia; BRCA cis rs7552404 0.696 rs1417405 chr1:76457797 T/C cg22875332 chr1:76189707 ACADM 0.56 10.06 0.37 3.37e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9733 0.596 rs12089731 chr1:150647798 T/C cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs473651 0.692 rs579511 chr2:239334914 C/G cg18131467 chr2:239335373 ASB1 0.94 32.28 0.79 2.42e-136 Multiple system atrophy; BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg16812893 chr21:31813075 KRTAP15-1 0.39 9.7 0.36 7.75e-21 HDL cholesterol; BRCA cis rs12545109 0.807 rs13263281 chr8:57346582 C/A cg09654669 chr8:57350985 NA -0.4 -8.81 -0.33 1.15e-17 Obesity-related traits; BRCA cis rs12142240 0.698 rs6659228 chr1:46811027 C/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.1 -0.34 1.15e-18 Menopause (age at onset); BRCA cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.830 rs35865860 chr4:98968822 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.64e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.534 rs1490109 chr12:34064077 T/C cg13010199 chr12:38710504 ALG10B 0.39 7.91 0.3 1.13e-14 Morning vs. evening chronotype; BRCA cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg19717773 chr7:2847554 GNA12 -0.43 -9.63 -0.36 1.43e-20 Height; BRCA cis rs11887277 0.741 rs12471783 chr2:27039919 A/G cg12368169 chr2:27073192 DPYSL5 -0.29 -8.17 -0.31 1.62e-15 Obesity-related traits; BRCA cis rs939658 0.683 rs1560895 chr15:79468082 A/G cg17916960 chr15:79447300 NA -0.39 -9.58 -0.35 2.18e-20 Refractive error; BRCA cis rs17376456 0.877 rs10044139 chr5:93407803 T/C cg25358565 chr5:93447407 FAM172A 1.22 18.67 0.59 2.2e-62 Diabetic retinopathy; BRCA cis rs1878931 0.624 rs39728 chr16:3453076 A/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.55 10.13 0.37 1.87e-22 Body mass index (adult); BRCA trans rs11098499 0.863 rs6858777 chr4:120475966 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg18402987 chr7:1209562 NA 0.85 12.22 0.44 5.38e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1801251 1.000 rs283480 chr2:233648742 G/A cg25237894 chr2:233734115 C2orf82 0.39 11.04 0.4 4.74e-26 Coronary artery disease; BRCA cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg00071950 chr4:10020882 SLC2A9 -0.51 -12.32 -0.44 1.95e-31 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs7301016 0.846 rs17732089 chr12:63023658 A/G cg01804193 chr12:63026212 NA -0.47 -8.24 -0.31 1.01e-15 IgG glycosylation; BRCA cis rs4268898 0.679 rs2551181 chr2:24437548 C/T cg06627628 chr2:24431161 ITSN2 0.73 13.87 0.48 1.93e-38 Asthma; BRCA cis rs2991971 1.000 rs2934859 chr1:46017836 C/T cg15605315 chr1:45957053 TESK2 0.46 9.44 0.35 6.61e-20 High light scatter reticulocyte count; BRCA cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg11764359 chr7:65958608 NA 0.67 15.15 0.51 1.68e-44 Aortic root size; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg11814155 chr7:99998594 ZCWPW1 0.47 8.41 0.32 2.78e-16 Platelet count; BRCA cis rs17608059 0.524 rs9897978 chr17:13900256 G/T cg11395062 chr17:14139857 CDRT15 -0.49 -10.93 -0.4 1.25e-25 Temperament; BRCA cis rs3760982 0.565 rs8104300 chr19:44293144 T/C cg11993925 chr19:44307056 LYPD5 0.37 8.77 0.33 1.6e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg17971929 chr21:40555470 PSMG1 -0.49 -10.84 -0.39 3.1e-25 Menarche (age at onset); BRCA cis rs4862750 0.914 rs6837117 chr4:187872379 C/T cg22105103 chr4:187893119 NA 0.33 10.72 0.39 8.67e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs477692 0.569 rs1762418 chr10:131303353 G/A cg05714579 chr10:131428358 MGMT 0.46 10.25 0.38 6.21e-23 Response to temozolomide; BRCA cis rs7833986 0.501 rs2719257 chr8:56940173 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.73 13.99 0.48 5.27e-39 Height; BRCA cis rs7917772 0.503 rs11191328 chr10:104305185 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.18 0.62 1.96e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs875971 0.545 rs1638724 chr7:66040481 A/G cg11764359 chr7:65958608 NA -0.65 -11.72 -0.42 7.28e-29 Aortic root size; BRCA cis rs2832191 1.000 rs6516891 chr21:30483070 C/T cg08807101 chr21:30365312 RNF160 -0.57 -13.92 -0.48 1.12e-38 Dental caries; BRCA cis rs897080 0.552 rs1067318 chr2:44634509 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.39 0.35 1.04e-19 Height; BRCA cis rs4853036 0.951 rs13011127 chr2:70040147 T/C cg02498382 chr2:70120550 SNRNP27 -0.48 -8.8 -0.33 1.23e-17 Colorectal or endometrial cancer; BRCA cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg14530993 chr4:882597 GAK 0.51 8.58 0.32 7.04e-17 Parkinson's disease; BRCA cis rs62458065 0.513 rs7788809 chr7:32552622 T/A cg20159608 chr7:32802032 NA -0.49 -9.4 -0.35 9.82e-20 Metabolite levels (HVA/MHPG ratio); BRCA cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 14.11 0.49 1.48e-39 Hip circumference adjusted for BMI; BRCA cis rs6964587 0.773 rs10488514 chr7:91951842 C/A cg17063962 chr7:91808500 NA 0.52 11.47 0.41 7.99e-28 Breast cancer; BRCA cis rs7894051 1.000 rs7074435 chr10:135190570 G/T cg24905316 chr10:135186343 ECHS1 0.62 9.58 0.35 2.12e-20 Lifespan; BRCA cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg13319975 chr6:146136371 FBXO30 -0.4 -9.14 -0.34 8.3e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05901451 chr6:126070800 HEY2 0.4 9.72 0.36 6.35e-21 Endometrial cancer; BRCA cis rs546131 0.928 rs483976 chr11:34840167 C/G cg11058730 chr11:34937778 PDHX;APIP 0.41 8.09 0.3 2.94e-15 Lung disease severity in cystic fibrosis; BRCA cis rs28595532 0.546 rs17516389 chr4:119239267 T/C cg21605333 chr4:119757512 SEC24D 0.82 8.61 0.32 5.8e-17 Cannabis dependence symptom count; BRCA cis rs738322 0.775 rs4375 chr22:38539041 T/C cg25457927 chr22:38595422 NA -0.33 -12.16 -0.43 9.55e-31 Cutaneous nevi; BRCA cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg11890956 chr21:40555474 PSMG1 -0.85 -21.97 -0.66 4.2e-80 Cognitive function; BRCA cis rs2050392 0.517 rs160018 chr10:30772703 T/C cg18806716 chr10:30721971 MAP3K8 -0.44 -10.0 -0.37 5.51e-22 Inflammatory bowel disease; BRCA cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg22455342 chr2:225449267 CUL3 0.66 17.09 0.56 3.17e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11890956 chr21:40555474 PSMG1 0.82 13.11 0.46 6.33e-35 Cognitive function; BRCA trans rs9467711 0.606 rs34273322 chr6:26415409 T/A cg01620082 chr3:125678407 NA -0.62 -8.23 -0.31 1.08e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7818345 0.845 rs11782540 chr8:19268251 A/G cg11303988 chr8:19266685 CSGALNACT1 0.35 8.97 0.33 3.25e-18 Language performance in older adults (adjusted for episodic memory); BRCA trans rs1422110 0.515 rs1155791 chr5:85417582 A/C cg01787110 chr1:109008453 NBPF6 0.49 10.72 0.39 9.06e-25 Attention function in attention deficit hyperactive disorder; BRCA cis rs2576037 0.526 rs538221 chr18:44375111 G/A cg19077165 chr18:44547161 KATNAL2 -0.51 -10.92 -0.4 1.37e-25 Personality dimensions; BRCA cis rs490234 0.812 rs12341150 chr9:128340770 C/T cg14078157 chr9:128172775 NA -0.48 -10.97 -0.4 8.89e-26 Mean arterial pressure; BRCA cis rs586533 0.846 rs1690809 chr11:99512037 C/T cg22878054 chr11:99397252 CNTN5 0.31 7.84 0.3 1.85e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs908922 0.676 rs498184 chr1:152501423 G/C cg20991723 chr1:152506922 NA 0.39 8.71 0.33 2.6e-17 Hair morphology; BRCA cis rs9986765 1.000 rs4565384 chr7:142811564 C/A cg22531018 chr7:142981779 TMEM139 0.59 9.76 0.36 4.54e-21 Cancer;Dermatomyositis; BRCA cis rs10463316 0.894 rs4099171 chr5:150766623 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.17e-16 Metabolite levels (Pyroglutamine); BRCA cis rs9790314 0.779 rs1599374 chr3:160891727 G/A cg04691961 chr3:161091175 C3orf57 -0.5 -11.05 -0.4 4.13e-26 Morning vs. evening chronotype; BRCA cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.56 0.32 8.42e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs758324 0.704 rs31480 chr5:131396332 C/T cg06307176 chr5:131281290 NA -0.46 -8.78 -0.33 1.53e-17 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2742417 0.603 rs2064062 chr3:45761115 G/C cg04837898 chr3:45731254 SACM1L -0.39 -8.07 -0.3 3.51e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs911555 0.755 rs10144051 chr14:103885931 A/C cg12935359 chr14:103987150 CKB -0.59 -13.47 -0.47 1.42e-36 Intelligence (multi-trait analysis); BRCA cis rs9790314 1.000 rs336548 chr3:161058412 T/C cg03342759 chr3:160939853 NMD3 -0.65 -13.83 -0.48 3.01e-38 Morning vs. evening chronotype; BRCA trans rs11098499 0.954 rs10031483 chr4:120422636 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.77 0.42 4.25e-29 Corneal astigmatism; BRCA cis rs4074536 0.536 rs12140557 chr1:116291066 G/A cg21648376 chr1:116311395 CASQ2 -0.49 -8.57 -0.32 7.66e-17 QRS duration; BRCA cis rs2153535 0.580 rs7769020 chr6:8457724 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA trans rs877282 0.583 rs12358255 chr10:828626 C/T cg22713356 chr15:30763199 NA 0.89 14.51 0.5 1.86e-41 Uric acid levels; BRCA cis rs7631605 0.905 rs6550445 chr3:37066369 T/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.68 0.36 9.27e-21 Cerebrospinal P-tau181p levels; BRCA trans rs17685 0.753 rs13240404 chr7:75675719 C/T cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.72 -0.74 1.21e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7833790 0.660 rs1451995 chr8:82746123 G/C cg17211192 chr8:82754475 SNX16 0.49 11.13 0.4 1.94e-26 Diastolic blood pressure; BRCA cis rs4268898 1.000 rs6746005 chr2:24434345 G/A cg06627628 chr2:24431161 ITSN2 0.5 10.36 0.38 2.4e-23 Asthma; BRCA cis rs8180040 0.966 rs34634681 chr3:47579102 G/A cg16586182 chr3:47516702 SCAP 0.63 13.82 0.48 3.36e-38 Colorectal cancer; BRCA trans rs208520 0.690 rs207094 chr6:66799009 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.01 -0.64 6.5e-75 Exhaled nitric oxide output; BRCA cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24110177 chr3:50126178 RBM5 -0.37 -9.9 -0.36 1.38e-21 Intelligence (multi-trait analysis); BRCA cis rs7586879 0.593 rs10198275 chr2:25130542 A/C cg01884057 chr2:25150051 NA 0.34 8.99 0.34 2.76e-18 Body mass index; BRCA cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.38e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.872 rs9487032 chr6:109605323 G/T cg12927641 chr6:109611667 NA -0.41 -10.85 -0.39 2.65e-25 Reticulocyte fraction of red cells; BRCA trans rs6479891 1.000 rs7895348 chr10:65109541 C/A cg14819942 chr15:35414228 NA -0.33 -8.18 -0.31 1.57e-15 Arthritis (juvenile idiopathic); BRCA cis rs751728 1.000 rs751728 chr6:33764033 C/T cg15252951 chr6:33757062 LEMD2 0.4 10.33 0.38 3.17e-23 Crohn's disease; BRCA trans rs11098499 0.863 rs1480939 chr4:120456927 T/C cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg11644478 chr21:40555479 PSMG1 -0.51 -10.9 -0.4 1.66e-25 Menarche (age at onset); BRCA trans rs1941687 0.583 rs8091977 chr18:31359414 T/C cg15819921 chr19:927150 ARID3A -0.4 -7.84 -0.3 1.94e-14 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs9309711 0.770 rs13409323 chr2:3488184 C/T cg10845886 chr2:3471009 TTC15 -0.71 -14.59 -0.5 8.34e-42 Neurofibrillary tangles; BRCA cis rs13161895 1.000 rs34027780 chr5:179478891 C/A cg02702477 chr5:179499311 RNF130 0.46 8.65 0.32 4.17e-17 LDL cholesterol; BRCA cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg24812749 chr6:127587940 RNF146 0.8 15.62 0.53 7.74e-47 Breast cancer; BRCA cis rs61931739 0.517 rs7958856 chr12:34294737 T/C cg06521331 chr12:34319734 NA -0.65 -11.99 -0.43 5.28e-30 Morning vs. evening chronotype; BRCA cis rs113835537 0.529 rs11227499 chr11:66272824 A/G cg24851651 chr11:66362959 CCS 0.39 8.0 0.3 6.07e-15 Airway imaging phenotypes; BRCA cis rs2637266 1.000 rs10824431 chr10:78356622 C/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs735396 0.770 rs1169315 chr12:121443753 T/G cg02403541 chr12:121454288 C12orf43 0.64 12.29 0.44 2.52e-31 N-glycan levels; BRCA cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg04450456 chr4:17643702 FAM184B -0.36 -10.44 -0.38 1.14e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs6582630 0.555 rs34730221 chr12:38405140 C/T cg06521331 chr12:34319734 NA 0.46 9.08 0.34 1.38e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs6750047 0.756 rs4670233 chr2:38272342 A/G cg07380506 chr2:38303506 CYP1B1 0.41 9.31 0.35 1.98e-19 Cutaneous malignant melanoma;Melanoma; BRCA trans rs853679 0.882 rs9393908 chr6:28190830 T/A cg01620082 chr3:125678407 NA -0.59 -8.24 -0.31 1.01e-15 Depression; BRCA cis rs7903847 0.642 rs7074511 chr10:99140177 G/A cg08345082 chr10:99160200 RRP12 -0.29 -8.53 -0.32 1.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs367943 0.712 rs1366393 chr5:112729472 A/G cg12552261 chr5:112820674 MCC 0.36 7.86 0.3 1.69e-14 Type 2 diabetes; BRCA cis rs9287719 0.649 rs12473957 chr2:10717714 C/G cg00105475 chr2:10696890 NA -0.41 -9.01 -0.34 2.44e-18 Prostate cancer; BRCA cis rs3806843 0.868 rs2531349 chr5:140120953 G/A cg11822812 chr5:140052017 DND1 -0.29 -8.06 -0.3 3.83e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg22508957 chr16:3507546 NAT15 -0.58 -8.65 -0.32 4.2e-17 Tuberculosis; BRCA cis rs11190604 0.767 rs10883481 chr10:102165021 G/A cg07080220 chr10:102295463 HIF1AN 0.51 10.54 0.38 4.47e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs798554 0.679 rs1636249 chr7:2884283 T/G cg04166393 chr7:2884313 GNA12 0.63 13.63 0.47 2.69e-37 Height; BRCA cis rs17095355 1.000 rs9988702 chr10:111703389 G/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.99 -0.37 6.01e-22 Biliary atresia; BRCA cis rs77633900 0.614 rs280014 chr15:76986890 A/G cg21673338 chr15:77095150 SCAPER -0.54 -9.98 -0.37 6.81e-22 Non-glioblastoma glioma;Glioma; BRCA cis rs589448 1.000 rs589448 chr12:69752200 A/G cg22834771 chr12:69754056 YEATS4 -0.42 -10.43 -0.38 1.27e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs644148 0.785 rs118112019 chr19:44965091 T/G cg15540054 chr19:45004280 ZNF180 0.47 9.22 0.34 4.36e-19 Personality dimensions; BRCA cis rs1468333 0.964 rs10479180 chr5:137581901 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.41 7.96 0.3 8.04e-15 Resting heart rate; BRCA cis rs1865760 0.827 rs9461227 chr6:25960815 C/T cg16482183 chr6:26056742 HIST1H1C 0.51 10.58 0.39 3.17e-24 Height; BRCA cis rs10751667 0.577 rs7946461 chr11:974035 A/G cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 6.69e-19 Alzheimer's disease (late onset); BRCA cis rs7208859 0.623 rs609063 chr17:28951513 A/G cg17105886 chr17:28927953 LRRC37B2 0.59 7.86 0.3 1.6e-14 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg26119090 chr2:26468346 HADHA;HADHB -1.01 -21.96 -0.66 4.55e-80 Gut microbiome composition (summer); BRCA cis rs6840360 0.615 rs58977077 chr4:152470239 T/G cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg16606324 chr3:10149918 C3orf24 0.52 10.03 0.37 4.4e-22 Alzheimer's disease; BRCA cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg04455712 chr21:45112962 RRP1B 0.42 10.71 0.39 1.02e-24 Mean corpuscular volume; BRCA cis rs6964587 0.934 rs7798973 chr7:91588360 G/A cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.72e-31 Breast cancer; BRCA cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg26647111 chr11:31128758 NA -0.45 -9.82 -0.36 2.73e-21 Bone mineral density (spine); BRCA cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs8028182 0.636 rs12708519 chr15:75803200 T/C cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs7727544 0.507 rs11741341 chr5:131570218 A/G cg09877947 chr5:131593287 PDLIM4 0.34 7.98 0.3 6.71e-15 Blood metabolite levels; BRCA cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -11.12 -0.4 2.32e-26 IgG glycosylation; BRCA cis rs514406 0.929 rs562178 chr1:53319562 T/C cg27535305 chr1:53392650 SCP2 -0.37 -9.26 -0.34 3.07e-19 Monocyte count; BRCA trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.99 0.3 6.37e-15 Corneal astigmatism; BRCA trans rs11098499 0.909 rs17046118 chr4:120387496 T/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA trans rs7819412 0.525 rs10086521 chr8:10783769 A/G cg06636001 chr8:8085503 FLJ10661 -0.5 -9.89 -0.36 1.51e-21 Triglycerides; BRCA cis rs2629540 0.889 rs17624662 chr10:126408146 A/C cg08799069 chr10:126477246 METTL10 0.46 9.35 0.35 1.4e-19 Cocaine dependence; BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg01262667 chr19:19385393 TM6SF2 0.41 10.62 0.39 2.16e-24 Tonsillectomy; BRCA cis rs1003719 0.715 rs8130643 chr21:38551715 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA cis rs13136331 0.568 rs13103299 chr4:88590012 T/C cg22416721 chr4:88570574 DMP1 0.61 14.33 0.49 1.43e-40 Sitting height ratio; BRCA cis rs7586879 0.789 rs7560156 chr2:25124794 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.56 0.35 2.4e-20 Body mass index; BRCA cis rs17270561 0.666 rs12209856 chr6:25793673 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.67 0.36 9.7e-21 Iron status biomarkers; BRCA cis rs7903847 0.642 rs11189175 chr10:99139609 T/C cg20016023 chr10:99160130 RRP12 -0.27 -8.64 -0.32 4.4e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2841277 0.708 rs4465542 chr14:105407798 A/G cg14403583 chr14:105418241 AHNAK2 -0.37 -8.61 -0.32 5.6e-17 Rheumatoid arthritis; BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs7267979 0.966 rs2257461 chr20:25265554 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs892961 1.000 rs892961 chr17:75400100 A/T cg05865280 chr17:75406074 SEPT9 0.46 12.64 0.45 7.59e-33 Airflow obstruction; BRCA cis rs1005277 0.579 rs1780122 chr10:38529509 C/A cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.01 -0.3 5.27e-15 Extrinsic epigenetic age acceleration; BRCA cis rs10504073 0.565 rs35282337 chr8:49920994 G/A cg00325661 chr8:49890786 NA 0.51 15.04 0.51 5.21e-44 Blood metabolite ratios; BRCA cis rs1577917 1.000 rs10455455 chr6:86670214 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -14.3 -0.49 1.94e-40 Response to antipsychotic treatment; BRCA cis rs6088590 0.735 rs2273684 chr20:33529766 G/T cg24642439 chr20:33292090 TP53INP2 -0.53 -11.27 -0.41 5.39e-27 Coronary artery disease; BRCA cis rs11583043 0.874 rs11578366 chr1:101396852 T/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.48 0.35 4.92e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs2180341 0.960 rs7756884 chr6:127684018 A/G cg27446573 chr6:127587934 RNF146 0.89 20.5 0.63 3.86e-72 Breast cancer; BRCA cis rs208515 0.556 rs1872309 chr6:66660432 A/C cg07460842 chr6:66804631 NA 0.73 12.71 0.45 3.88e-33 Exhaled nitric oxide levels; BRCA cis rs2576037 0.526 rs2257027 chr18:44566990 A/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -9.4 -0.35 9.79e-20 Personality dimensions; BRCA cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg12641515 chr19:46296257 DMWD 0.71 17.61 0.57 7.39e-57 Coronary artery disease; BRCA cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.68 11.24 0.41 7.45e-27 Lung function (FEV1/FVC); BRCA trans rs9291683 0.609 rs34709913 chr4:10028955 T/C cg26043149 chr18:55253948 FECH 0.41 8.91 0.33 5.1e-18 Bone mineral density; BRCA cis rs1505368 0.505 rs1394781 chr2:213248822 C/T cg20637307 chr2:213403960 ERBB4 -0.36 -8.41 -0.32 2.67e-16 Symmetrical dimethylarginine levels; BRCA cis rs6582630 0.638 rs12831496 chr12:38552604 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.23 -0.38 7.77e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs3741151 0.773 rs17244602 chr11:73219907 A/G cg17517138 chr11:73019481 ARHGEF17 -0.71 -10.65 -0.39 1.74e-24 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs503734 0.502 rs348880 chr3:100981426 A/G cg27318481 chr3:100970896 IMPG2 -0.41 -9.83 -0.36 2.42e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3812049 0.784 rs7734927 chr5:127453735 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 10.56 0.39 3.82e-24 Lymphocyte counts;Red cell distribution width; BRCA cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg06618935 chr21:46677482 NA -0.38 -8.39 -0.32 3.11e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6546550 0.935 rs1056482 chr2:70108256 A/T cg02498382 chr2:70120550 SNRNP27 -0.42 -9.28 -0.34 2.67e-19 Prevalent atrial fibrillation; BRCA cis rs73242632 1.000 rs73242623 chr4:57840543 C/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.69 8.28 0.31 7.48e-16 Congenital heart disease (maternal effect); BRCA cis rs1153858 1.000 rs2114501 chr15:45670316 G/A cg21132104 chr15:45694354 SPATA5L1 0.74 16.82 0.55 7.77e-53 Homoarginine levels; BRCA cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg25281562 chr12:121454272 C12orf43 0.36 9.45 0.35 6.07e-20 N-glycan levels; BRCA cis rs1801251 1.000 rs11679079 chr2:233612656 C/T cg25237894 chr2:233734115 C2orf82 0.4 11.47 0.41 8.37e-28 Coronary artery disease; BRCA cis rs7011049 1.000 rs117708010 chr8:53844026 G/A cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs7267979 1.000 rs2387884 chr20:25379069 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.24 -0.31 9.57e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9790314 0.765 rs4856768 chr3:161004392 G/A cg03342759 chr3:160939853 NMD3 -0.67 -15.68 -0.53 3.83e-47 Morning vs. evening chronotype; BRCA cis rs870825 0.616 rs2130394 chr4:185642577 C/A cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.74e-54 Blood protein levels; BRCA cis rs1790761 0.520 rs4930461 chr11:67394895 A/G cg08355456 chr11:67383691 NA 0.41 8.53 0.32 1.04e-16 Mean corpuscular volume; BRCA cis rs61990749 0.597 rs176952 chr14:78180736 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.64 10.06 0.37 3.36e-22 Fibroblast growth factor basic levels; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg22638593 chr5:131593259 PDLIM4 0.3 7.88 0.3 1.41e-14 Breast cancer; BRCA cis rs7408868 1.000 rs10420466 chr19:15261371 G/T cg14696996 chr19:15285081 NOTCH3 0.96 14.34 0.49 1.17e-40 Pulse pressure; BRCA cis rs929596 0.517 rs3806592 chr2:234625936 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -10.99 -0.4 7.33e-26 Total bilirubin levels in HIV-1 infection; BRCA cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg04455712 chr21:45112962 RRP1B 0.41 11.08 0.4 3.32e-26 Mean corpuscular volume; BRCA cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.49 -8.83 -0.33 1.02e-17 Renal function-related traits (BUN); BRCA cis rs9393777 0.513 rs13215020 chr6:26656073 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs208520 0.837 rs208509 chr6:66941706 A/G cg07460842 chr6:66804631 NA -0.82 -14.66 -0.5 3.59e-42 Exhaled nitric oxide output; BRCA trans rs2832077 0.689 rs2832052 chr21:30130073 G/C cg14791747 chr16:20752902 THUMPD1 0.32 8.81 0.33 1.16e-17 Cognitive test performance; BRCA trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg13010199 chr12:38710504 ALG10B 0.5 9.82 0.36 2.62e-21 Morning vs. evening chronotype; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg07308232 chr7:1071921 C7orf50 -0.46 -9.5 -0.35 4.25e-20 Longevity;Endometriosis; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 16.95 0.56 1.65e-53 Platelet count; BRCA cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg06238570 chr21:40685208 BRWD1 -0.43 -8.46 -0.32 1.8e-16 Cognitive function; BRCA cis rs4853036 0.951 rs10496175 chr2:70153848 A/G cg02498382 chr2:70120550 SNRNP27 -0.51 -9.24 -0.34 3.75e-19 Colorectal or endometrial cancer; BRCA cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg23649088 chr2:200775458 C2orf69 0.72 16.16 0.54 1.72e-49 Osteoporosis; BRCA cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg10820045 chr2:198174542 NA 0.4 9.27 0.34 2.7e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7927771 0.524 rs12421563 chr11:47780222 G/A cg20307385 chr11:47447363 PSMC3 -0.41 -9.68 -0.36 9.19e-21 Subjective well-being; BRCA cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg03806693 chr22:41940476 POLR3H 1.06 20.43 0.63 8.87e-72 Vitiligo; BRCA cis rs4780401 0.728 rs8057398 chr16:11780629 G/T cg01061890 chr16:11836724 TXNDC11 -0.41 -8.85 -0.33 8.57e-18 Rheumatoid arthritis; BRCA cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg11366901 chr6:160182831 ACAT2 0.78 15.21 0.52 8.47e-45 Age-related macular degeneration (geographic atrophy); BRCA trans rs61931739 0.853 rs7133716 chr12:34041847 G/C cg26384229 chr12:38710491 ALG10B -0.42 -9.38 -0.35 1.09e-19 Morning vs. evening chronotype; BRCA cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg09658497 chr7:2847517 GNA12 -0.41 -8.62 -0.32 5.06e-17 Height; BRCA trans rs11165623 0.564 rs6673207 chr1:96999259 C/G cg10631902 chr5:14652156 NA -0.43 -12.24 -0.44 4.16e-31 Hip circumference;Waist circumference; BRCA cis rs2549794 0.511 rs27645 chr5:96163439 A/C cg16492584 chr5:96139282 ERAP1 -0.3 -7.88 -0.3 1.45e-14 Crohn's disease; BRCA cis rs9653442 0.712 rs6749757 chr2:100730111 A/C cg22139774 chr2:100720529 AFF3 0.29 8.29 0.31 6.63e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs6977660 0.943 rs12668201 chr7:19831610 A/C cg05791153 chr7:19748676 TWISTNB -0.39 -8.14 -0.31 2.05e-15 Thyroid stimulating hormone; BRCA cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg15128208 chr22:42549153 NA 0.31 8.05 0.3 4.2e-15 Cognitive function; BRCA cis rs4561483 0.832 rs171656 chr16:11953167 C/T cg08843971 chr16:11963173 GSPT1 -0.51 -11.42 -0.41 1.34e-27 Testicular germ cell tumor; BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -9.28 -0.34 2.65e-19 Alzheimer's disease; BRCA cis rs7684253 0.565 rs13130605 chr4:57810071 G/A cg11939399 chr4:57773300 REST 0.29 7.92 0.3 1.05e-14 Migraine; BRCA cis rs12760731 0.720 rs2175254 chr1:178319105 G/A cg00404053 chr1:178313656 RASAL2 0.69 8.7 0.33 2.83e-17 Obesity-related traits; BRCA cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg16482183 chr6:26056742 HIST1H1C 0.74 14.54 0.5 1.42e-41 Iron status biomarkers; BRCA cis rs35110281 0.837 rs2838341 chr21:45076443 A/G cg01579765 chr21:45077557 HSF2BP -0.42 -11.8 -0.42 3.16e-29 Mean corpuscular volume; BRCA cis rs9790314 0.846 rs9809522 chr3:160983768 G/C cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.09e-59 Morning vs. evening chronotype; BRCA cis rs6598955 0.671 rs11579630 chr1:26612297 C/A cg00852783 chr1:26633632 UBXN11 -0.49 -8.25 -0.31 8.77e-16 Obesity-related traits; BRCA cis rs17685 0.753 rs1637044 chr7:75703744 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.85 -0.33 8.3e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg06108461 chr20:60628389 TAF4 -0.99 -22.17 -0.66 3.29e-81 Body mass index; BRCA cis rs7552404 0.727 rs1144336 chr1:76277421 C/A cg10523679 chr1:76189770 ACADM 0.58 11.0 0.4 6.66e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4853036 0.629 rs34704699 chr2:70014710 G/A cg02498382 chr2:70120550 SNRNP27 -0.46 -8.04 -0.3 4.29e-15 Colorectal or endometrial cancer; BRCA cis rs7264396 0.563 rs3827029 chr20:34332784 G/T cg04508476 chr20:34239394 CPNE1;RBM12 0.64 11.49 0.41 6.63e-28 Total cholesterol levels; BRCA cis rs1506403 0.685 rs10281506 chr7:142823928 C/T cg22531018 chr7:142981779 TMEM139 0.43 8.37 0.31 3.67e-16 Cancer; BRCA cis rs7267979 1.000 rs6050561 chr20:25334855 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.18 -0.31 1.58e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6570726 0.791 rs365869 chr6:145884751 C/T cg13319975 chr6:146136371 FBXO30 -0.39 -8.89 -0.33 6.2e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs12478296 0.792 rs57482298 chr2:243011148 C/A cg06360820 chr2:242988706 NA -0.88 -15.52 -0.52 2.57e-46 Obesity-related traits; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg11814155 chr7:99998594 ZCWPW1 0.43 8.28 0.31 6.98e-16 Platelet count; BRCA trans rs1493916 0.748 rs1845386 chr18:31318256 C/G cg27147174 chr7:100797783 AP1S1 -0.43 -8.27 -0.31 8.05e-16 Life satisfaction; BRCA cis rs1862618 0.853 rs6450409 chr5:56101399 A/G cg20203395 chr5:56204925 C5orf35 -0.49 -10.35 -0.38 2.6e-23 Initial pursuit acceleration; BRCA cis rs1865760 1.000 rs9358895 chr6:25924655 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.46 0.38 9.53e-24 Height; BRCA cis rs1401999 1.000 rs869417 chr3:183689138 T/C cg01324343 chr3:183735012 ABCC5 0.83 21.02 0.64 6.06e-75 Anterior chamber depth; BRCA cis rs922692 0.744 rs12899147 chr15:79079512 A/G cg04896959 chr15:78267971 NA 0.37 8.68 0.32 3.17e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg16325326 chr1:53192061 ZYG11B -0.91 -24.95 -0.7 1.81e-96 Monocyte count; BRCA cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.67 0.45 5.57e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.42 9.43 0.35 7.5599999999999994e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs12471809 chr2:26307140 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.12 -0.31 2.47e-15 Gut microbiome composition (summer); BRCA cis rs6866344 0.568 rs10516147 chr5:178094484 A/G cg03877680 chr5:178157825 ZNF354A 0.61 10.16 0.37 1.43e-22 Neutrophil percentage of white cells; BRCA trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg06606381 chr12:133084897 FBRSL1 -0.7 -7.97 -0.3 7.21e-15 Depression; BRCA cis rs736408 0.609 rs13087772 chr3:52782274 T/G cg18404041 chr3:52824283 ITIH1 -0.43 -12.84 -0.45 9.96e-34 Bipolar disorder; BRCA cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -10.21 -0.37 8.94e-23 Extrinsic epigenetic age acceleration; BRCA cis rs7267979 0.966 rs2261784 chr20:25262396 G/C cg08601574 chr20:25228251 PYGB 0.36 8.73 0.33 2.23e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs72781680 1.000 rs72788286 chr2:24098321 A/C cg20701182 chr2:24300061 SF3B14 0.57 8.97 0.33 3.37e-18 Lymphocyte counts; BRCA cis rs17253792 0.822 rs10142757 chr14:56074211 C/A cg01858014 chr14:56050164 KTN1 -0.77 -10.52 -0.38 5.49e-24 Putamen volume; BRCA cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg24308560 chr3:49941425 MST1R 0.39 8.51 0.32 1.25e-16 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg14926445 chr8:58193284 C8orf71 -0.42 -8.13 -0.31 2.17e-15 Developmental language disorder (linguistic errors); BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.64 13.62 0.47 2.82e-37 Lymphocyte counts; BRCA cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg18850127 chr7:39170497 POU6F2 0.55 12.14 0.43 1.16e-30 IgG glycosylation; BRCA cis rs7246657 0.943 rs2291004 chr19:37997952 C/A cg18154014 chr19:37997991 ZNF793 0.63 12.15 0.43 1.04e-30 Coronary artery calcification; BRCA cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 8.98e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg21475434 chr5:93447410 FAM172A 0.69 8.73 0.33 2.15e-17 Diabetic retinopathy; BRCA cis rs1215050 0.791 rs260899 chr4:98707046 G/A cg05340658 chr4:99064831 C4orf37 0.45 10.41 0.38 1.48e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9443645 0.869 rs9443626 chr6:79629564 G/C cg11833968 chr6:79620685 NA -0.4 -8.78 -0.33 1.55e-17 Intelligence (multi-trait analysis); BRCA trans rs9951602 0.512 rs6506868 chr18:76642559 C/G cg02800362 chr5:177631904 HNRNPAB 0.76 17.47 0.57 3.91e-56 Obesity-related traits; BRCA cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg24562669 chr7:97807699 LMTK2 0.45 12.28 0.44 2.88e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs4713118 0.955 rs9468201 chr6:27687035 C/T cg20933634 chr6:27740509 NA 0.44 8.43 0.32 2.24e-16 Parkinson's disease; BRCA cis rs9462027 0.628 rs1998702 chr6:34741917 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.03 -0.3 4.79e-15 Systemic lupus erythematosus; BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg25036284 chr2:26402008 FAM59B -0.64 -10.59 -0.39 3.03e-24 Gut microbiome composition (summer); BRCA cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.02 -0.34 2.17e-18 Alzheimer's disease (late onset); BRCA cis rs7100689 0.646 rs1340382 chr10:82096997 G/C cg00277334 chr10:82204260 NA -0.44 -8.59 -0.32 6.6e-17 Post bronchodilator FEV1; BRCA cis rs2404602 0.647 rs11072610 chr15:76930805 C/A cg23625390 chr15:77176239 SCAPER -0.53 -12.7 -0.45 4.29e-33 Blood metabolite levels; BRCA cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg14689365 chr7:158441557 NCAPG2 -0.42 -8.37 -0.31 3.68e-16 Height; BRCA cis rs7264396 0.563 rs56941405 chr20:34313426 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.18 -0.43 7.96e-31 Total cholesterol levels; BRCA cis rs4727027 0.800 rs10952796 chr7:148813138 G/C cg23583168 chr7:148888333 NA -0.76 -17.63 -0.57 5.59e-57 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs12618769 0.652 rs11896729 chr2:99225645 T/C cg10123293 chr2:99228465 UNC50 0.41 8.36 0.31 3.98e-16 Bipolar disorder; BRCA cis rs2354432 0.607 rs6677679 chr1:146803630 C/T cg25205988 chr1:146714368 CHD1L -0.91 -13.1 -0.46 6.75e-35 Mitochondrial DNA levels; BRCA cis rs6594713 0.756 rs10053341 chr5:112784007 G/T cg12552261 chr5:112820674 MCC 0.47 8.13 0.31 2.29e-15 Brain cytoarchitecture; BRCA cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.34 -7.86 -0.3 1.67e-14 High light scatter reticulocyte count; BRCA cis rs10464366 0.957 rs11765705 chr7:39106942 G/T cg18850127 chr7:39170497 POU6F2 0.39 8.26 0.31 8.58e-16 IgG glycosylation; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg00814883 chr7:100076585 TSC22D4 -0.52 -11.86 -0.42 1.78e-29 Platelet count; BRCA cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg17845761 chr1:175162550 KIAA0040 -0.26 -10.08 -0.37 2.83e-22 Alcohol dependence; BRCA cis rs6866344 0.570 rs11740283 chr5:178136440 T/C cg03877680 chr5:178157825 ZNF354A 0.84 16.83 0.55 6.89e-53 Neutrophil percentage of white cells; BRCA cis rs2180341 0.960 rs9398840 chr6:127669744 G/A cg24812749 chr6:127587940 RNF146 0.87 20.03 0.62 1.31e-69 Breast cancer; BRCA cis rs2421770 0.530 rs3847622 chr11:35368700 A/G cg13971030 chr11:35366721 SLC1A2 0.44 9.83 0.36 2.57e-21 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs2842992 0.915 rs2842985 chr6:160085434 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.68 17.04 0.56 6.06e-54 Age-related macular degeneration (geographic atrophy); BRCA trans rs28595532 0.557 rs12498329 chr4:119311524 C/T cg26518628 chr1:97050305 NA -0.58 -10.62 -0.39 2.18e-24 Cannabis dependence symptom count; BRCA cis rs3125734 0.633 rs10821968 chr10:63993905 C/T cg19640130 chr10:64028056 RTKN2 0.33 9.74 0.36 5.17e-21 Rheumatoid arthritis; BRCA cis rs4713118 0.513 rs149951 chr6:28033087 T/C cg10876282 chr6:28092338 ZSCAN16 0.4 7.91 0.3 1.17e-14 Parkinson's disease; BRCA cis rs7119038 0.509 rs11216960 chr11:118577873 G/A cg19308663 chr11:118741387 NA 0.38 8.53 0.32 1.1e-16 Sjögren's syndrome; BRCA cis rs7582180 0.629 rs7597615 chr2:100954828 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.66 0.42 1.32e-28 Intelligence (multi-trait analysis); BRCA cis rs7945705 0.520 rs1984791 chr11:9035027 C/T cg12365402 chr11:9010492 NRIP3 0.39 7.99 0.3 6.36e-15 Hemoglobin concentration; BRCA cis rs9914988 0.887 rs12451790 chr17:27112000 C/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg14847009 chr1:175162515 KIAA0040 -0.25 -9.45 -0.35 6.06e-20 Alcohol dependence; BRCA cis rs911555 0.706 rs10129426 chr14:104018455 C/T cg12935359 chr14:103987150 CKB -0.52 -12.64 -0.45 7.23e-33 Intelligence (multi-trait analysis); BRCA cis rs17401966 0.838 rs6541089 chr1:10402785 A/G cg03954927 chr1:10346856 KIF1B 0.44 13.98 0.48 6.18e-39 Hepatocellular carcinoma; BRCA cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg05340658 chr4:99064831 C4orf37 0.59 12.67 0.45 5.43e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs34734847 0.965 rs2005455 chr12:121128699 A/G cg21892295 chr12:121157589 UNC119B -0.41 -12.48 -0.44 3.79e-32 Mean corpuscular volume; BRCA cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg15017067 chr4:17643749 FAM184B 0.26 7.86 0.3 1.61e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg13628971 chr7:2884303 GNA12 0.41 9.21 0.34 4.76e-19 Height; BRCA cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg00074818 chr8:8560427 CLDN23 0.39 8.51 0.32 1.23e-16 Obesity-related traits; BRCA cis rs11971779 0.711 rs6961204 chr7:139047399 T/G cg07862535 chr7:139043722 LUC7L2 0.47 11.91 0.43 1.16e-29 Diisocyanate-induced asthma; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg02353165 chr6:42928485 GNMT 0.94 27.25 0.73 4.33e-109 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs950776 0.518 rs2869544 chr15:78839400 G/A cg22563815 chr15:78856949 CHRNA5 -0.36 -8.5 -0.32 1.34e-16 Sudden cardiac arrest; BRCA cis rs10504229 0.769 rs17215649 chr8:58152791 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs17253792 0.915 rs28537145 chr14:56179119 G/A cg01858014 chr14:56050164 KTN1 -0.66 -8.39 -0.31 3.19e-16 Putamen volume; BRCA cis rs9831754 1.000 rs3946823 chr3:78353052 G/A cg06138941 chr3:78371609 NA -0.81 -17.6 -0.57 7.74e-57 Calcium levels; BRCA cis rs6430585 0.697 rs115944351 chr2:136515458 G/A cg07169764 chr2:136633963 MCM6 1.23 26.19 0.72 2.99e-103 Corneal structure; BRCA cis rs9443645 0.901 rs1538233 chr6:79743735 G/T cg18132916 chr6:79620363 NA -0.48 -10.95 -0.4 1.09e-25 Intelligence (multi-trait analysis); BRCA cis rs6835098 1.000 rs1054496 chr4:174089080 A/G cg08422745 chr4:174089978 GALNT7 -0.79 -16.77 -0.55 1.33e-52 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg01262667 chr19:19385393 TM6SF2 -0.42 -10.88 -0.4 1.99e-25 Tonsillectomy; BRCA cis rs11098499 0.954 rs12510138 chr4:120423935 C/G cg09307838 chr4:120376055 NA 0.72 15.68 0.53 3.89e-47 Corneal astigmatism; BRCA cis rs889312 0.500 rs702688 chr5:56190986 A/G cg12311346 chr5:56204834 C5orf35 -0.39 -7.94 -0.3 9.41e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs7267979 1.000 rs2424713 chr20:25418482 C/T cg08601574 chr20:25228251 PYGB 0.37 8.59 0.32 6.76e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1878931 0.624 rs27241 chr16:3447282 C/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.55 -9.94 -0.37 9.63e-22 Body mass index (adult); BRCA cis rs11955398 0.501 rs4235480 chr5:60032371 C/T cg02684056 chr5:59996105 DEPDC1B -0.41 -9.5 -0.35 4.27e-20 Intelligence (multi-trait analysis); BRCA cis rs10752881 0.839 rs6692207 chr1:183085304 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.77 0.58 1.01e-57 Colorectal cancer; BRCA cis rs2346177 0.513 rs1530625 chr2:46658067 C/T cg26688816 chr2:46740690 ATP6V1E2 -0.39 -8.55 -0.32 9.05e-17 HDL cholesterol; BRCA cis rs826838 1.000 rs11183747 chr12:38822595 A/G cg26384229 chr12:38710491 ALG10B -0.83 -22.19 -0.66 2.46e-81 Heart rate; BRCA trans rs3857536 0.776 rs9363560 chr6:66949686 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg11644478 chr21:40555479 PSMG1 -0.67 -15.09 -0.51 3.07e-44 Cognitive function; BRCA cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg15145296 chr3:125709740 NA -0.55 -8.65 -0.32 4.23e-17 Blood pressure (smoking interaction); BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.56 8.97 0.33 3.3e-18 Renal function-related traits (BUN); BRCA cis rs2354432 0.660 rs10751415 chr1:146830785 T/A cg25205988 chr1:146714368 CHD1L 0.88 12.52 0.44 2.69e-32 Mitochondrial DNA levels; BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg04166393 chr7:2884313 GNA12 0.47 9.49 0.35 4.43e-20 Height; BRCA cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg11584989 chr19:19387371 SF4 0.63 13.5 0.47 1e-36 Bipolar disorder; BRCA cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg23711669 chr6:146136114 FBXO30 0.79 18.81 0.6 3.73e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg03188948 chr7:1209495 NA 0.44 8.77 0.33 1.56e-17 Longevity;Endometriosis; BRCA cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg01689657 chr7:91764605 CYP51A1 0.25 8.85 0.33 8.51e-18 Breast cancer; BRCA cis rs7945705 0.818 rs1988708 chr11:8882893 C/A cg12365402 chr11:9010492 NRIP3 -0.37 -8.4 -0.32 2.97e-16 Hemoglobin concentration; BRCA cis rs2742234 0.541 rs10899779 chr10:43723976 C/T cg15436174 chr10:43711423 RASGEF1A 0.54 10.68 0.39 1.35e-24 Hirschsprung disease; BRCA cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg18404041 chr3:52824283 ITIH1 -0.47 -14.1 -0.49 1.62e-39 Bipolar disorder; BRCA cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg03433033 chr1:76189801 ACADM 0.68 13.06 0.46 1.06e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4808199 0.895 rs10421505 chr19:19459554 C/T cg03709012 chr19:19516395 GATAD2A 0.91 17.82 0.58 5.64e-58 Nonalcoholic fatty liver disease; BRCA cis rs1267303 0.675 rs1745370 chr1:46982863 C/G cg25110126 chr1:46999211 NA -0.62 -11.38 -0.41 1.92e-27 Monobrow; BRCA cis rs7615952 0.576 rs12497295 chr3:125818650 G/A cg05084668 chr3:125655381 ALG1L -0.47 -8.1 -0.31 2.84e-15 Blood pressure (smoking interaction); BRCA cis rs35306767 0.903 rs12244355 chr10:944465 T/C cg20503657 chr10:835505 NA 1.03 18.33 0.59 1.26e-60 Eosinophil percentage of granulocytes; BRCA cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs858239 0.601 rs10263110 chr7:23160551 G/A cg23682824 chr7:23144976 KLHL7 0.42 11.09 0.4 2.96e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.82 0.6 3.34e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.94 0.3 9.23e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7903847 0.642 rs11189196 chr10:99155079 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.55 -0.32 9.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs35762459 1 rs35762459 chr11:8844653 T/TA cg21881798 chr11:8931708 C11orf17;ST5 -0.45 -9.82 -0.36 2.65e-21 Immature fraction of reticulocytes; BRCA cis rs13046373 0.535 rs35909098 chr21:32021649 C/T cg14062083 chr21:31802829 KRTAP13-4 0.35 9.51 0.35 3.87e-20 HDL cholesterol; BRCA cis rs1865760 0.663 rs9379815 chr6:25980116 T/A cg17691542 chr6:26056736 HIST1H1C 0.48 10.13 0.37 1.84e-22 Height; BRCA cis rs858239 0.601 rs1558313 chr7:23156079 G/A cg23682824 chr7:23144976 KLHL7 0.42 11.09 0.4 2.96e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs68170813 0.559 rs76167266 chr7:106900664 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.65 -0.32 4.02e-17 Coronary artery disease; BRCA cis rs7312933 0.618 rs6582390 chr12:42634586 C/T cg01256987 chr12:42539512 GXYLT1 -0.44 -8.57 -0.32 8.02e-17 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.4 0.35 9.73e-20 Parkinson's disease; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg21782813 chr7:2030301 MAD1L1 0.42 11.22 0.41 8.65e-27 Bipolar disorder and schizophrenia; BRCA trans rs2727020 0.754 rs10839226 chr11:49150883 C/G cg15704280 chr7:45808275 SEPT13 -0.48 -9.75 -0.36 4.87e-21 Coronary artery disease; BRCA cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -9.16 -0.34 6.97e-19 Schizophrenia; BRCA cis rs514406 0.929 rs515857 chr1:53336859 A/G cg08859206 chr1:53392774 SCP2 -0.46 -9.46 -0.35 5.66e-20 Monocyte count; BRCA cis rs13315871 0.929 rs1045115 chr3:58305199 C/T cg20936604 chr3:58311152 NA -0.62 -8.26 -0.31 8.45e-16 Cholesterol, total; BRCA cis rs6835098 0.509 rs2332655 chr4:174093002 A/G cg08422745 chr4:174089978 GALNT7 0.53 11.38 0.41 1.87e-27 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2073300 0.609 rs6137914 chr20:23358364 C/T cg12062639 chr20:23401060 NAPB 0.96 13.45 0.47 1.64e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.54 0.32 9.95e-17 Electroencephalogram traits; BRCA cis rs11690935 0.851 rs10930502 chr2:172890588 A/G cg13550731 chr2:172543902 DYNC1I2 -0.79 -22.17 -0.66 3.35e-81 Schizophrenia; BRCA trans rs7647973 0.626 rs9829155 chr3:49817450 T/C cg21659725 chr3:3221576 CRBN 0.48 8.7 0.33 2.83e-17 Menarche (age at onset); BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.82e-19 Total body bone mineral density; BRCA trans rs61931739 0.500 rs7979240 chr12:34509026 C/T cg26384229 chr12:38710491 ALG10B 0.73 16.25 0.54 5.95e-50 Morning vs. evening chronotype; BRCA cis rs1008375 1.000 rs10939740 chr4:17617490 T/C cg04450456 chr4:17643702 FAM184B 0.35 10.13 0.37 1.8e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9487051 0.898 rs882072 chr6:109611806 A/G cg21918786 chr6:109611834 NA -0.49 -13.96 -0.48 7.5e-39 Reticulocyte fraction of red cells; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg27170947 chr2:26402098 FAM59B -0.94 -16.9 -0.56 3.15e-53 Gut microbiome composition (summer); BRCA cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg19539972 chr4:7069911 GRPEL1 0.66 16.03 0.54 7.73e-49 Monocyte percentage of white cells; BRCA cis rs3858526 0.834 rs10839160 chr11:6002113 T/C cg05234568 chr11:5960015 NA -0.46 -9.22 -0.34 4.34e-19 DNA methylation (variation); BRCA cis rs4820539 1.000 rs2157710 chr22:23457486 C/T cg14186256 chr22:23484241 RTDR1 0.75 22.46 0.66 8.1e-83 Bone mineral density; BRCA cis rs17401966 1.000 rs1339458 chr1:10328338 C/T cg15208524 chr1:10270712 KIF1B 0.36 7.85 0.3 1.72e-14 Hepatocellular carcinoma; BRCA cis rs801193 0.967 rs2707853 chr7:66214010 G/A cg11764359 chr7:65958608 NA 0.68 15.06 0.51 4.35e-44 Aortic root size; BRCA trans rs12517041 0.935 rs10053181 chr5:23293265 A/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg23505145 chr19:12996616 KLF1 0.54 12.19 0.43 7.29e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg11952622 chr19:58962976 ZNF324B 0.46 9.52 0.35 3.51e-20 Uric acid clearance; BRCA cis rs2276314 0.857 rs56230698 chr18:33628885 A/G cg19628046 chr18:33552617 C18orf21 0.53 10.63 0.39 2.08e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs877282 0.945 rs71491311 chr10:791747 G/A cg17470449 chr10:769945 NA 0.51 8.58 0.32 7.24e-17 Uric acid levels; BRCA cis rs60871478 1.000 rs62432250 chr7:801792 C/G cg05535760 chr7:792225 HEATR2 0.72 13.11 0.46 5.99e-35 Cerebrospinal P-tau181p levels; BRCA cis rs17270561 0.609 rs6924782 chr6:25735816 C/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg20503657 chr10:835505 NA 1.03 18.41 0.59 4.71e-61 Eosinophil percentage of granulocytes; BRCA cis rs55788414 0.932 rs12102728 chr16:81181436 C/T cg06400318 chr16:81190750 PKD1L2 -0.51 -8.81 -0.33 1.15e-17 Left ventricular obstructive tract defect (maternal effect); BRCA cis rs9291683 0.530 rs4235346 chr4:9945296 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -11.2 -0.41 1.04e-26 Bone mineral density; BRCA cis rs4629710 0.545 rs2077490 chr6:131554184 C/T cg12606694 chr6:131520996 AKAP7 0.43 9.29 0.34 2.47e-19 Multiple myeloma (IgH translocation); BRCA cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg11266682 chr4:10021025 SLC2A9 0.45 11.99 0.43 4.9e-30 Bone mineral density; BRCA cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg06238570 chr21:40685208 BRWD1 -0.47 -9.26 -0.34 3.12e-19 Cognitive function; BRCA cis rs7246657 0.722 rs8110865 chr19:38047387 G/A cg23950597 chr19:37808831 NA -0.5 -8.62 -0.32 5.36e-17 Coronary artery calcification; BRCA cis rs6547741 1.000 rs1919126 chr2:27801418 C/A cg27432699 chr2:27873401 GPN1 0.46 9.7 0.36 7.89e-21 Oral cavity cancer; BRCA cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg00631329 chr6:26305371 NA -0.46 -13.06 -0.46 9.65e-35 Educational attainment; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg00106254 chr7:1943704 MAD1L1 -0.33 -8.29 -0.31 6.78e-16 Bipolar disorder and schizophrenia; BRCA cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg12463550 chr7:65579703 CRCP -0.36 -7.87 -0.3 1.53e-14 Aortic root size; BRCA cis rs10464366 0.560 rs11763728 chr7:39145862 C/T cg18850127 chr7:39170497 POU6F2 0.43 9.67 0.36 9.44e-21 IgG glycosylation; BRCA cis rs4595586 0.525 rs2892450 chr12:39363678 G/A cg26384229 chr12:38710491 ALG10B 0.41 9.24 0.34 3.61e-19 Morning vs. evening chronotype; BRCA cis rs2153535 0.606 rs11243253 chr6:8380193 T/C cg21535247 chr6:8435926 SLC35B3 -0.37 -8.22 -0.31 1.1e-15 Motion sickness; BRCA cis rs6740322 0.895 rs6738717 chr2:43573670 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -12.11 -0.43 1.54e-30 Coronary artery disease; BRCA trans rs62103177 0.733 rs62096748 chr18:77619699 T/C cg05926928 chr17:57297772 GDPD1 1.2 16.07 0.54 4.61e-49 Opioid sensitivity; BRCA trans rs459571 0.883 rs2520096 chr9:136919416 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -14.69 -0.5 2.65e-42 Platelet distribution width; BRCA cis rs524281 0.861 rs11227415 chr11:65885459 C/T cg16950941 chr11:66035639 RAB1B 0.39 8.48 0.32 1.6e-16 Electroencephalogram traits; BRCA cis rs2115630 1.000 rs10220733 chr15:85280864 G/A cg12863693 chr15:85201151 NMB -0.34 -8.08 -0.3 3.17e-15 P wave terminal force; BRCA cis rs473651 0.904 rs508274 chr2:239337723 G/A cg18131467 chr2:239335373 ASB1 0.95 34.27 0.8 7.02e-147 Multiple system atrophy; BRCA cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs1568889 1.000 rs7933332 chr11:28036392 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.84 0.51 5.04e-43 Bipolar disorder; BRCA cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg08999081 chr20:33150536 PIGU 0.47 13.03 0.46 1.35e-34 Glomerular filtration rate (creatinine); BRCA cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg18876405 chr7:65276391 NA -0.7 -18.11 -0.58 1.82e-59 Aortic root size; BRCA cis rs10267417 0.535 rs6960579 chr7:19869364 A/G cg07541023 chr7:19748670 TWISTNB 0.51 9.17 0.34 6.47e-19 Night sleep phenotypes; BRCA cis rs2197308 0.740 rs11182251 chr12:37919611 C/T cg13010199 chr12:38710504 ALG10B -0.41 -8.73 -0.33 2.13e-17 Morning vs. evening chronotype; BRCA cis rs7301826 1.000 rs10848205 chr12:131280714 A/G cg11011512 chr12:131303247 STX2 0.39 9.66 0.36 1.09e-20 Plasma plasminogen activator levels; BRCA cis rs875971 1.000 rs11974219 chr7:65647410 C/T cg11764359 chr7:65958608 NA -0.8 -19.46 -0.61 1.39e-66 Aortic root size; BRCA cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg01283332 chr5:1856932 NA -0.32 -7.85 -0.3 1.8e-14 Cardiovascular disease risk factors; BRCA cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6684514 0.961 rs12048077 chr1:156299916 T/A cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2130392 0.926 rs10428357 chr4:185636217 T/A cg21366198 chr4:185655624 MLF1IP -0.42 -10.23 -0.38 7.34e-23 Kawasaki disease; BRCA cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.56 11.91 0.43 1.11e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg21138405 chr5:131827807 IRF1 0.36 8.6 0.32 6.16e-17 Asthma (sex interaction); BRCA cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg12310025 chr6:25882481 NA -0.44 -10.84 -0.39 3.12e-25 Blood metabolite levels; BRCA cis rs826838 1.000 rs7953227 chr12:38946193 G/A cg13010199 chr12:38710504 ALG10B 0.53 11.65 0.42 1.36e-28 Heart rate; BRCA cis rs13102973 0.864 rs7435952 chr4:135900983 C/T cg14419869 chr4:135874104 NA 0.47 9.42 0.35 7.94e-20 Subjective well-being; BRCA cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg05868516 chr6:26286170 HIST1H4H -0.48 -10.77 -0.39 5.93e-25 Educational attainment; BRCA cis rs13256369 0.708 rs10903310 chr8:8589687 A/C cg17143192 chr8:8559678 CLDN23 -0.47 -8.59 -0.32 6.78e-17 Obesity-related traits; BRCA cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg24829409 chr8:58192753 C8orf71 -0.47 -9.08 -0.34 1.35e-18 Developmental language disorder (linguistic errors); BRCA cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.44 11.94 0.43 8.47e-30 Response to bleomycin (chromatid breaks); BRCA cis rs7523273 0.606 rs2724380 chr1:207949682 C/T cg22525895 chr1:207977042 MIR29B2 0.47 12.02 0.43 3.87e-30 Schizophrenia; BRCA cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg02659138 chr7:134003124 SLC35B4 -0.33 -9.62 -0.36 1.45e-20 Mean platelet volume; BRCA cis rs8028182 0.636 rs11637068 chr15:75743002 G/A cg20655648 chr15:75932815 IMP3 0.4 7.86 0.3 1.69e-14 Sudden cardiac arrest; BRCA cis rs6860806 0.661 rs2136187 chr5:131577894 T/C cg12564285 chr5:131593104 PDLIM4 0.37 9.79 0.36 3.66e-21 Breast cancer; BRCA cis rs9467773 0.595 rs2172007 chr6:26639777 A/C cg11502198 chr6:26597334 ABT1 0.48 9.45 0.35 6.1e-20 Intelligence (multi-trait analysis); BRCA cis rs7520050 0.807 rs4660312 chr1:46110572 A/G cg24296786 chr1:45957014 TESK2 -0.46 -10.65 -0.39 1.7e-24 Red blood cell count;Reticulocyte count; BRCA trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21659725 chr3:3221576 CRBN -0.47 -8.55 -0.32 9.32e-17 Menarche (age at onset); BRCA cis rs965469 0.779 rs6051771 chr20:3328271 A/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg13298116 chr11:62369859 EML3;MTA2 0.55 10.88 0.4 2.04e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs10193935 1.000 rs10190326 chr2:42388262 A/C cg27598129 chr2:42591480 NA 0.87 14.58 0.5 8.85e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg12373951 chr3:133503437 NA 0.44 10.49 0.38 7.27e-24 Iron status biomarkers; BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs514406 0.607 rs6665324 chr1:53201610 G/A cg08859206 chr1:53392774 SCP2 0.46 10.21 0.37 8.87e-23 Monocyte count; BRCA trans rs526821 0.595 rs517627 chr11:55356489 C/T cg11707556 chr5:10655725 ANKRD33B -0.36 -8.08 -0.3 3.19e-15 Pediatric bone mineral density (spine); BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.57 11.44 0.41 1.02e-27 Tonsillectomy; BRCA cis rs262150 0.579 rs4909110 chr7:158787332 C/T cg17987982 chr7:158820591 NA -0.43 -8.14 -0.31 2.08e-15 Facial morphology (factor 20); BRCA cis rs12586317 0.547 rs28589276 chr14:35478865 A/G cg05294307 chr14:35346193 BAZ1A -0.59 -10.3 -0.38 4.09e-23 Psoriasis; BRCA cis rs11122272 0.735 rs2808596 chr1:231530723 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -12.39 -0.44 9.69e-32 Hemoglobin concentration; BRCA cis rs7312933 0.558 rs11181463 chr12:42763636 C/T cg01256987 chr12:42539512 GXYLT1 -0.42 -8.16 -0.31 1.85e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs13082711 0.595 rs4973762 chr3:27364789 A/T cg02860705 chr3:27208620 NA 0.71 13.37 0.47 3.98e-36 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs10924970 0.967 rs1933246 chr1:235391446 T/C cg26050004 chr1:235667680 B3GALNT2 0.35 8.76 0.33 1.8e-17 Asthma; BRCA trans rs1493916 0.905 rs7239283 chr18:31395397 G/A cg27147174 chr7:100797783 AP1S1 -0.58 -11.79 -0.42 3.49e-29 Life satisfaction; BRCA cis rs3617 0.625 rs2240915 chr3:52859526 T/A cg11645453 chr3:52864694 ITIH4 0.37 9.9 0.36 1.4e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs367943 1.000 rs1057827 chr5:112823768 T/C cg12552261 chr5:112820674 MCC 0.55 12.07 0.43 2.28e-30 Type 2 diabetes; BRCA cis rs6728642 0.808 rs114192053 chr2:97871906 G/A cg26665480 chr2:98280029 ACTR1B -0.66 -7.93 -0.3 9.55e-15 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs17253792 0.822 rs10133962 chr14:56066088 G/A cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg13397359 chr6:42928475 GNMT 0.66 15.79 0.53 1.12e-47 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs77972916 0.536 rs7589361 chr2:43589328 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.58 -10.17 -0.37 1.29e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.18 0.34 5.9e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10197940 0.578 rs2045025 chr2:152317531 T/C cg19508488 chr2:152266495 RIF1 0.38 8.28 0.31 6.97e-16 Lung cancer; BRCA cis rs858239 0.632 rs7811903 chr7:23119056 A/G cg23682824 chr7:23144976 KLHL7 0.45 11.82 0.42 2.63e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg24675658 chr1:53192096 ZYG11B 0.68 14.71 0.5 2.16e-42 Monocyte count; BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA trans rs1493916 0.870 rs7235698 chr18:31382486 A/G cg27147174 chr7:100797783 AP1S1 -0.52 -10.57 -0.39 3.69e-24 Life satisfaction; BRCA cis rs11997175 0.624 rs12677772 chr8:33772521 T/C ch.8.33884649F chr8:33765107 NA 0.45 10.62 0.39 2.22e-24 Body mass index; BRCA cis rs400736 0.602 rs4573544 chr1:8165247 C/T cg25007680 chr1:8021821 PARK7 -0.35 -8.75 -0.33 1.9e-17 Response to antidepressants and depression; BRCA cis rs6964587 1.000 rs10243241 chr7:91705696 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.01 0.3 5.36e-15 Breast cancer; BRCA trans rs61931739 0.890 rs1197560 chr12:34121447 G/C cg26384229 chr12:38710491 ALG10B 0.44 10.53 0.38 5.07e-24 Morning vs. evening chronotype; BRCA cis rs6964587 0.967 rs7801058 chr7:91784381 C/T cg17063962 chr7:91808500 NA 0.54 12.64 0.45 7.91e-33 Breast cancer; BRCA cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg20476274 chr7:133979776 SLC35B4 -0.59 -15.49 -0.52 3.57e-46 Mean platelet volume; BRCA cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg07917127 chr4:99064746 C4orf37 0.42 7.97 0.3 7.51e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg11266682 chr4:10021025 SLC2A9 -0.38 -10.01 -0.37 5.43e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11105298 0.891 rs11105310 chr12:89918677 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.64 -0.36 1.23e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs1580019 0.961 rs3801328 chr7:32496930 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.51 0.32 1.26e-16 Cognitive ability; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg02951883 chr7:2050386 MAD1L1 -0.57 -13.07 -0.46 8.81e-35 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg18132916 chr6:79620363 NA -0.49 -11.1 -0.4 2.67e-26 Intelligence (multi-trait analysis); BRCA cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg13736514 chr6:26305472 NA -0.35 -11.59 -0.42 2.44e-28 Educational attainment; BRCA cis rs3096299 0.685 rs4785571 chr16:89565169 A/G cg02187348 chr16:89574699 SPG7 0.44 10.33 0.38 3.02e-23 Multiple myeloma (IgH translocation); BRCA cis rs4242434 0.927 rs11778693 chr8:22462852 T/C cg03733263 chr8:22462867 KIAA1967 1.03 24.94 0.7 2.14e-96 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs9393777 0.513 rs7740197 chr6:26663478 C/T cg12292205 chr6:26970375 C6orf41 0.46 8.02 0.3 5.25e-15 Intelligence (multi-trait analysis); BRCA cis rs7520050 0.771 rs4660882 chr1:46116292 C/T cg24296786 chr1:45957014 TESK2 -0.46 -10.6 -0.39 2.74e-24 Red blood cell count;Reticulocyte count; BRCA cis rs16910800 0.731 rs56768542 chr11:23191946 A/G cg20040320 chr11:23191996 NA -0.59 -10.19 -0.37 1.11e-22 Cancer; BRCA cis rs17376456 0.757 rs6859757 chr5:93206042 C/T cg25358565 chr5:93447407 FAM172A 1.2 17.51 0.57 2.23e-56 Diabetic retinopathy; BRCA cis rs858239 0.899 rs10085838 chr7:23298415 C/A cg23682824 chr7:23144976 KLHL7 0.33 8.28 0.31 7.34e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs12586317 0.514 rs61100068 chr14:35400232 A/T cg16230307 chr14:35515116 FAM177A1 0.78 15.56 0.52 1.6e-46 Psoriasis; BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg16606324 chr3:10149918 C3orf24 0.46 8.17 0.31 1.69e-15 Alzheimer's disease; BRCA cis rs13046373 0.508 rs2253516 chr21:31993317 C/T cg06468780 chr21:31798236 KRTAP13-3 0.33 8.13 0.31 2.24e-15 HDL cholesterol; BRCA cis rs6963495 0.745 rs75805443 chr7:105162828 A/G cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg18402987 chr7:1209562 NA 0.82 11.83 0.42 2.38e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10751667 0.600 rs10902266 chr11:1005697 G/T cg06064525 chr11:970664 AP2A2 -0.29 -8.49 -0.32 1.47e-16 Alzheimer's disease (late onset); BRCA cis rs2398668 0.570 rs4721548 chr7:2330496 A/G cg08027265 chr7:2291960 NA -0.31 -7.9 -0.3 1.25e-14 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.07 0.62 7.34e-70 Platelet count; BRCA cis rs2842992 0.830 rs1475123 chr6:160178007 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.67 16.3 0.54 3.13e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg00071950 chr4:10020882 SLC2A9 0.56 13.87 0.48 1.9e-38 Bone mineral density; BRCA cis rs12477438 0.520 rs13018891 chr2:99755099 C/G cg08885076 chr2:99613938 TSGA10 0.45 10.64 0.39 1.8e-24 Chronic sinus infection; BRCA cis rs7737355 0.947 rs4705894 chr5:131079288 A/G cg06307176 chr5:131281290 NA 0.51 10.09 0.37 2.52e-22 Life satisfaction; BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 24.67 0.7 6.7e-95 Platelet count; BRCA cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg03517284 chr6:25882590 NA -0.51 -11.54 -0.42 4.09e-28 Blood metabolite levels; BRCA cis rs10504073 0.647 rs341807 chr8:50032676 C/T cg00325661 chr8:49890786 NA 0.38 10.94 0.4 1.21e-25 Blood metabolite ratios; BRCA cis rs6028335 0.674 rs67379757 chr20:37671051 C/G cg16355469 chr20:37678765 NA 0.51 9.04 0.34 1.86e-18 Alcohol and nicotine co-dependence; BRCA cis rs870825 0.616 rs6833858 chr4:185639961 C/T cg04058563 chr4:185651563 MLF1IP 0.8 18.17 0.58 8.56e-60 Blood protein levels; BRCA cis rs7264396 0.887 rs11698935 chr20:34075015 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.38 -7.87 -0.3 1.5e-14 Total cholesterol levels; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.79 -12.49 -0.44 3.49e-32 Platelet count; BRCA cis rs2645694 0.533 rs2703125 chr4:77819900 T/C cg18351406 chr4:77819688 ANKRD56 0.61 13.3 0.47 7.98e-36 Emphysema distribution in smoking; BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26314531 chr2:26401878 FAM59B 0.65 11.21 0.41 9.87e-27 Gut microbiome composition (summer); BRCA cis rs11809207 0.574 rs2783633 chr1:26505265 A/G cg00147160 chr1:26503991 CNKSR1 0.29 9.39 0.35 1e-19 Height; BRCA cis rs72781680 0.950 rs72796402 chr2:24180104 A/G cg08917208 chr2:24149416 ATAD2B 1.1 15.51 0.52 2.65e-46 Lymphocyte counts; BRCA cis rs877529 0.625 rs713841 chr22:39529029 A/G cg18708252 chr22:39545030 CBX7 -0.37 -8.75 -0.33 1.89e-17 Multiple myeloma; BRCA cis rs7818345 1.000 rs11204041 chr8:19291371 G/A cg11303988 chr8:19266685 CSGALNACT1 0.31 8.06 0.3 3.7e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg19623624 chr10:135278901 LOC619207 -0.43 -10.19 -0.37 1.1e-22 Systemic lupus erythematosus; BRCA cis rs4728302 0.838 rs10225454 chr7:133591535 G/C cg07491979 chr7:133331646 EXOC4 0.36 7.82 0.3 2.17e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.13 0.31 2.19e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7586879 0.964 rs4077679 chr2:25122852 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.23 0.34 3.91e-19 Body mass index; BRCA cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg14847009 chr1:175162515 KIAA0040 0.24 8.84 0.33 9.36e-18 Alcohol dependence; BRCA cis rs1865760 0.820 rs9348697 chr6:25890834 C/T cg17691542 chr6:26056736 HIST1H1C 0.5 10.4 0.38 1.67e-23 Height; BRCA cis rs4566357 0.615 rs3769645 chr2:227913717 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -8.92 -0.33 4.81e-18 Coronary artery disease; BRCA cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg08999081 chr20:33150536 PIGU 0.44 12.5 0.44 3.03e-32 Glomerular filtration rate (creatinine); BRCA cis rs1448094 0.512 rs6539924 chr12:86236935 T/C cg19622623 chr12:86230825 RASSF9 -0.34 -9.49 -0.35 4.41e-20 Major depressive disorder; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg03188948 chr7:1209495 NA 0.6 11.35 0.41 2.54e-27 Longevity;Endometriosis; BRCA cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg24324837 chr19:49891574 CCDC155 0.52 9.38 0.35 1.09e-19 Multiple sclerosis; BRCA cis rs7587476 0.784 rs13026390 chr2:215687075 C/T cg04004882 chr2:215674386 BARD1 -0.61 -11.2 -0.41 9.99e-27 Neuroblastoma; BRCA cis rs9309711 0.961 rs11675119 chr2:3476422 C/A cg16153549 chr2:3496821 NA -0.38 -8.63 -0.32 4.86e-17 Neurofibrillary tangles; BRCA cis rs858239 0.570 rs6968242 chr7:23167411 T/G cg23682824 chr7:23144976 KLHL7 0.45 12.03 0.43 3.48e-30 Cerebrospinal fluid biomarker levels; BRCA trans rs7829975 0.688 rs6995407 chr8:8384647 C/G cg16141378 chr3:129829833 LOC729375 -0.32 -7.98 -0.3 6.59e-15 Mood instability; BRCA trans rs7980799 0.649 rs11052732 chr12:33657801 A/G cg26384229 chr12:38710491 ALG10B -0.52 -11.01 -0.4 5.92e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA trans rs1997103 1.000 rs6977292 chr7:55396335 T/C cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg23992470 chr4:843637 GAK 0.53 8.43 0.32 2.28e-16 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs1896154 chr4:99021161 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7408868 1.000 rs7408868 chr19:15285679 G/C cg14696996 chr19:15285081 NOTCH3 0.94 13.72 0.48 1.02e-37 Pulse pressure; BRCA cis rs11690935 0.550 rs6730085 chr2:172864845 C/A cg13550731 chr2:172543902 DYNC1I2 0.49 12.15 0.43 1.02e-30 Schizophrenia; BRCA cis rs9309473 0.519 rs2421574 chr2:73908767 C/G cg20560298 chr2:73613845 ALMS1 0.38 9.93 0.37 1.01e-21 Metabolite levels; BRCA cis rs4308124 0.708 rs10179596 chr2:111970380 G/A cg04571233 chr2:111982156 NA -0.45 -9.58 -0.35 2.04e-20 Vitiligo; BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg09877947 chr5:131593287 PDLIM4 0.39 10.02 0.37 4.92e-22 Breast cancer; BRCA cis rs9287719 0.967 rs2024431 chr2:10731327 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.09 -0.3 3.04e-15 Prostate cancer; BRCA cis rs1949733 0.701 rs940134 chr4:8454870 C/T cg13073564 chr4:8508604 NA -0.39 -10.61 -0.39 2.43e-24 Response to antineoplastic agents; BRCA cis rs11690935 0.959 rs10194102 chr2:172626143 G/C cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.59 -0.77 2.82e-127 Schizophrenia; BRCA cis rs6752107 0.935 rs10929322 chr2:234149702 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 -0.45 -10.05 -0.37 3.62e-22 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2153535 0.542 rs1120393 chr6:8486890 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.62 0.39 2.29e-24 Motion sickness; BRCA cis rs6545883 0.791 rs2600665 chr2:61405795 G/T cg15711740 chr2:61764176 XPO1 -0.5 -12.32 -0.44 1.96e-31 Tuberculosis; BRCA cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg18904891 chr8:8559673 CLDN23 0.65 13.1 0.46 6.52e-35 Obesity-related traits; BRCA cis rs1865760 0.865 rs6929805 chr6:25950834 T/A cg16482183 chr6:26056742 HIST1H1C 0.5 10.38 0.38 1.99e-23 Height; BRCA cis rs12310956 0.532 rs10506119 chr12:33963684 A/G cg06521331 chr12:34319734 NA -0.61 -11.11 -0.4 2.37e-26 Morning vs. evening chronotype; BRCA cis rs77741769 0.571 rs3861797 chr12:121255334 T/C cg02419362 chr12:121203948 SPPL3 0.33 7.83 0.3 1.98e-14 Mean corpuscular volume; BRCA cis rs12310956 0.532 rs6488187 chr12:33975029 C/T cg06521331 chr12:34319734 NA -0.57 -11.27 -0.41 5.32e-27 Morning vs. evening chronotype; BRCA cis rs2288073 1.000 rs2288073 chr2:24413298 C/T cg26838691 chr2:24397539 C2orf84 0.48 8.76 0.33 1.78e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg24110177 chr3:50126178 RBM5 0.52 15.68 0.53 4e-47 Body mass index; BRCA cis rs6831352 0.918 rs2602893 chr4:100044095 G/T cg13256891 chr4:100009986 ADH5 0.52 9.67 0.36 1e-20 Alcohol dependence; BRCA cis rs9287719 0.967 rs4470306 chr2:10743998 C/T cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg00814883 chr7:100076585 TSC22D4 -0.49 -10.28 -0.38 4.61e-23 Platelet count; BRCA cis rs7577696 0.539 rs2280972 chr2:32377961 C/T cg02381751 chr2:32503542 YIPF4 -0.48 -8.44 -0.32 2.09e-16 Inflammatory biomarkers; BRCA cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.85 -0.3 1.82e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4706831 0.647 rs627240 chr6:80985885 C/A cg08355045 chr6:80787529 NA -0.31 -8.08 -0.3 3.24e-15 Joint mobility (Beighton score); BRCA cis rs752010 0.619 rs6702659 chr1:42112236 T/C cg06885757 chr1:42089581 HIVEP3 0.32 10.6 0.39 2.77e-24 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs1559088 0.501 rs35492529 chr19:33597495 C/G cg17764715 chr19:33622953 WDR88 0.5 8.06 0.3 3.71e-15 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg23978390 chr7:1156363 C7orf50 0.4 8.13 0.31 2.2e-15 Bronchopulmonary dysplasia; BRCA cis rs8103278 1.000 rs9676288 chr19:46292060 G/T cg20908204 chr19:46285434 DMPK -0.29 -8.57 -0.32 7.99e-17 Coronary artery disease; BRCA cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.03 0.4 4.9e-26 Bipolar disorder; BRCA cis rs6866344 0.697 rs62392832 chr5:178134395 T/C cg10224037 chr5:178157518 ZNF354A 0.73 15.57 0.52 1.36e-46 Neutrophil percentage of white cells; BRCA cis rs36051895 0.626 rs3780368 chr9:5093188 G/C cg02405213 chr9:5042618 JAK2 -0.5 -9.04 -0.34 1.78e-18 Pediatric autoimmune diseases; BRCA cis rs2742417 0.624 rs2673030 chr3:45757900 T/G cg04837898 chr3:45731254 SACM1L -0.4 -8.15 -0.31 1.87e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs4237845 0.591 rs4760344 chr12:58320783 A/T cg00677455 chr12:58241039 CTDSP2 0.49 10.24 0.38 7.18e-23 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.39 0.35 1e-19 Tonsillectomy; BRCA cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.94 -0.4 1.14e-25 Schizophrenia; BRCA cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.85 18.9 0.6 1.31e-63 Smoking behavior; BRCA cis rs10746514 0.813 rs9724918 chr1:232248087 C/T cg09506761 chr1:232265262 NA 0.48 10.38 0.38 1.95e-23 Response to statin therapy; BRCA cis rs13064411 0.696 rs9836396 chr3:113184282 T/C cg18753928 chr3:113234510 CCDC52 -0.54 -11.21 -0.41 9.33e-27 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs5167 0.504 rs4803781 chr19:45459671 C/T cg09555818 chr19:45449301 APOC2 0.47 12.49 0.44 3.52e-32 Blood protein levels; BRCA cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11890956 chr21:40555474 PSMG1 1.04 29.91 0.76 1.32e-123 Cognitive function; BRCA cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg06453172 chr10:134556979 INPP5A -0.6 -11.82 -0.42 2.81e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs9951602 0.512 rs4799246 chr18:76653417 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 18.16 0.58 9.86e-60 Obesity-related traits; BRCA cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.52e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs738322 0.600 rs6001035 chr22:38562425 A/G cg25457927 chr22:38595422 NA -0.34 -12.44 -0.44 5.79e-32 Cutaneous nevi; BRCA cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg12927641 chr6:109611667 NA 0.42 10.96 0.4 9.53e-26 Reticulocyte fraction of red cells; BRCA cis rs262150 0.842 rs2657398 chr7:158784911 T/C cg26536863 chr7:158807979 LOC154822 0.36 8.4 0.32 3e-16 Facial morphology (factor 20); BRCA cis rs7666738 0.515 rs11733968 chr4:98906448 A/C cg05340658 chr4:99064831 C4orf37 -0.55 -10.96 -0.4 9.82e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs9788682 0.747 rs2568485 chr15:78752114 C/T cg24631222 chr15:78858424 CHRNA5 -0.51 -10.13 -0.37 1.87e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg19717773 chr7:2847554 GNA12 -0.43 -9.75 -0.36 4.86e-21 Height; BRCA cis rs9811920 0.809 rs1387647 chr3:99826942 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.52 12.37 0.44 1.18e-31 Axial length; BRCA cis rs7766436 0.885 rs5010014 chr6:22587299 A/G cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA cis rs7618501 0.633 rs6792892 chr3:49995518 T/C cg24308560 chr3:49941425 MST1R -0.4 -8.57 -0.32 7.82e-17 Intelligence (multi-trait analysis); BRCA cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg24812749 chr6:127587940 RNF146 0.69 15.63 0.53 7.31e-47 Breast cancer; BRCA cis rs2762353 0.904 rs13197601 chr6:25785935 G/A cg12310025 chr6:25882481 NA 0.52 12.44 0.44 5.51e-32 Blood metabolite levels; BRCA cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg21573476 chr21:45109991 RRP1B -0.31 -8.08 -0.3 3.3e-15 Mean corpuscular volume; BRCA cis rs1577917 0.958 rs6454488 chr6:86450842 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -8.04 -0.3 4.33e-15 Response to antipsychotic treatment; BRCA cis rs2455601 0.638 rs2248245 chr11:8988350 G/A cg21881798 chr11:8931708 C11orf17;ST5 -0.43 -7.93 -0.3 9.71e-15 Schizophrenia; BRCA cis rs3771570 1.000 rs60209440 chr2:242260340 G/C cg21155796 chr2:242212141 HDLBP 0.6 9.38 0.35 1.09e-19 Prostate cancer; BRCA trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg25482853 chr8:67687455 SGK3 1.06 17.06 0.56 4.86e-54 Lung disease severity in cystic fibrosis; BRCA cis rs6582630 0.519 rs12578283 chr12:38325349 A/T cg26384229 chr12:38710491 ALG10B 0.74 17.28 0.56 3.44e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs6835098 0.961 rs2078475 chr4:174098226 A/C cg08422745 chr4:174089978 GALNT7 0.76 14.55 0.5 1.27e-41 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs11105298 0.891 rs11105309 chr12:89909850 T/C cg00757033 chr12:89920650 WDR51B 0.54 11.07 0.4 3.49e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg10523679 chr1:76189770 ACADM 0.78 18.6 0.59 4.97e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg22535103 chr8:58192502 C8orf71 -0.61 -13.39 -0.47 3.29e-36 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg25036284 chr2:26402008 FAM59B -0.83 -14.94 -0.51 1.6e-43 Gut microbiome composition (summer); BRCA cis rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05901451 chr6:126070800 HEY2 0.4 9.72 0.36 6.35e-21 Endometrial cancer; BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.64 10.52 0.38 5.7e-24 Renal function-related traits (BUN); BRCA cis rs2404602 0.647 rs11634266 chr15:77093461 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.88 -0.48 1.77e-38 Blood metabolite levels; BRCA trans rs4650994 1.000 rs4650995 chr1:178517316 C/T cg05059571 chr16:84539110 KIAA1609 -0.42 -9.6 -0.36 1.71e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg04025307 chr7:1156635 C7orf50 0.46 8.93 0.33 4.45e-18 Bronchopulmonary dysplasia; BRCA cis rs875971 1.000 rs1968225 chr7:65874773 T/C cg18876405 chr7:65276391 NA 0.56 13.33 0.47 6.11e-36 Aortic root size; BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.66 10.84 0.39 2.92e-25 Renal function-related traits (BUN); BRCA cis rs12612619 0.659 rs12997235 chr2:27229079 A/C cg00617064 chr2:27272375 NA 0.31 8.02 0.3 5.1e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs4953318 0.694 rs3768747 chr2:46352058 G/T cg12428440 chr2:46370979 PRKCE -0.41 -9.54 -0.35 2.99e-20 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs10504229 0.953 rs75585481 chr8:58192202 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg04972856 chr6:88032051 C6orf162;GJB7 0.29 7.85 0.3 1.81e-14 Monocyte percentage of white cells; BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg23285459 chr7:2802560 GNA12 -0.34 -8.6 -0.32 6.27e-17 Height; BRCA cis rs4906332 1.000 rs4900574 chr14:103879024 G/A cg04998671 chr14:104000505 TRMT61A 0.41 9.34 0.35 1.54e-19 Coronary artery disease; BRCA cis rs6426558 0.537 rs648877 chr1:227283614 A/G cg10327440 chr1:227177885 CDC42BPA 0.48 9.48 0.35 5.08e-20 Neutrophil percentage of white cells; BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg21226059 chr5:178986404 RUFY1 0.5 13.8 0.48 4.34e-38 Lung cancer; BRCA cis rs9790314 1.000 rs62279921 chr3:161065441 T/C cg03342759 chr3:160939853 NMD3 -0.62 -13.12 -0.46 5.46e-35 Morning vs. evening chronotype; BRCA cis rs7552404 1.000 rs7513559 chr1:76173744 A/G cg10523679 chr1:76189770 ACADM 0.76 15.66 0.53 5.17e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2180341 0.842 rs9372860 chr6:127546605 G/A cg24812749 chr6:127587940 RNF146 0.79 15.37 0.52 1.4e-45 Breast cancer; BRCA cis rs9354352 0.967 rs9354351 chr6:66696271 G/A cg07460842 chr6:66804631 NA 0.64 13.82 0.48 3.46e-38 Initial pursuit acceleration in psychotic disorders; BRCA cis rs4074536 0.625 rs3827737 chr1:116312824 C/T cg21648376 chr1:116311395 CASQ2 -0.53 -8.51 -0.32 1.23e-16 QRS duration; BRCA cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -11.92 -0.43 9.74e-30 Tonsillectomy; BRCA cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg18016565 chr1:150552671 MCL1 0.35 8.41 0.32 2.67e-16 Tonsillectomy; BRCA cis rs7264396 0.690 rs2425183 chr20:34450621 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.12 0.31 2.39e-15 Total cholesterol levels; BRCA cis rs7918232 0.662 rs10741125 chr10:27288925 G/A cg14240646 chr10:27532245 ACBD5 -0.61 -10.08 -0.37 2.78e-22 Breast cancer; BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg03709012 chr19:19516395 GATAD2A 0.8 18.21 0.58 5.59e-60 Tonsillectomy; BRCA cis rs921968 0.541 rs523305 chr2:219402691 T/C cg10223061 chr2:219282414 VIL1 -0.27 -8.12 -0.31 2.37e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs57221529 0.709 rs72703034 chr5:577101 C/T cg09021430 chr5:549028 NA -0.68 -14.24 -0.49 3.68e-40 Lung disease severity in cystic fibrosis; BRCA cis rs9527 0.615 rs7080462 chr10:104736699 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.73 0.39 8.24e-25 Arsenic metabolism; BRCA cis rs6429082 0.791 rs61836205 chr1:235638753 C/G cg26050004 chr1:235667680 B3GALNT2 0.57 13.44 0.47 1.95e-36 Adiposity; BRCA cis rs501916 0.605 rs11070612 chr15:48073174 C/G cg16110827 chr15:48056943 SEMA6D -0.41 -8.76 -0.33 1.72e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA trans rs61931739 0.500 rs11053222 chr12:34481100 C/A cg26384229 chr12:38710491 ALG10B 0.75 16.82 0.55 8.24e-53 Morning vs. evening chronotype; BRCA cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg02659138 chr7:134003124 SLC35B4 0.31 9.7 0.36 7.37e-21 Mean platelet volume; BRCA cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs617791 0.530 rs55947178 chr11:65754230 G/A cg09783858 chr11:65769428 EIF1AD;BANF1 0.48 8.78 0.33 1.52e-17 Breast cancer; BRCA cis rs7613875 0.600 rs1138536 chr3:50153356 C/T cg14019146 chr3:50243930 SLC38A3 -0.44 -10.61 -0.39 2.5300000000000002e-24 Body mass index; BRCA cis rs2439831 0.850 rs7179388 chr15:44123945 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.79 12.91 0.45 4.77e-34 Lung cancer in ever smokers; BRCA cis rs9368481 0.547 rs2093303 chr6:26864406 C/T cg12292205 chr6:26970375 C6orf41 0.64 14.68 0.5 2.89e-42 Autism spectrum disorder or schizophrenia; BRCA cis rs8031584 0.918 rs34331396 chr15:31248736 C/G cg08704250 chr15:31115839 NA -0.36 -8.82 -0.33 1.05e-17 Huntington's disease progression; BRCA cis rs10129255 0.500 rs6576229 chr14:107186773 G/A cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.43e-17 Kawasaki disease; BRCA cis rs4268898 0.552 rs4665663 chr2:24372139 G/C cg06627628 chr2:24431161 ITSN2 0.41 8.66 0.32 3.8e-17 Asthma; BRCA cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg12756686 chr19:29218302 NA 0.53 9.14 0.34 8.46e-19 Methadone dose in opioid dependence; BRCA cis rs9790314 1.000 rs9846756 chr3:160983809 A/C cg03342759 chr3:160939853 NMD3 -0.62 -12.99 -0.46 2e-34 Morning vs. evening chronotype; BRCA cis rs7903847 0.642 rs11189180 chr10:99143529 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.7e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7917772 0.582 rs12411442 chr10:104349531 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7267979 1.000 rs6037121 chr20:25428311 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12493885 0.818 rs61791543 chr3:153766797 C/G cg17054900 chr3:154042577 DHX36 -0.49 -8.46 -0.32 1.89e-16 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9527 0.590 rs7087459 chr10:104790999 T/C cg04362960 chr10:104952993 NT5C2 0.44 10.01 0.37 5.06e-22 Arsenic metabolism; BRCA trans rs1997103 1.000 rs2177802 chr7:55410789 G/A cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs897080 0.515 rs1085486 chr2:44617324 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.06 0.37 3.23e-22 Height; BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg04166393 chr7:2884313 GNA12 0.46 8.94 0.33 4.09e-18 Height; BRCA cis rs6964587 1.000 rs60147309 chr7:91736098 C/G cg17063962 chr7:91808500 NA 0.54 12.83 0.45 1.06e-33 Breast cancer; BRCA trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg15704280 chr7:45808275 SEPT13 0.52 8.96 0.33 3.48e-18 Axial length; BRCA cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg12419862 chr22:24373484 LOC391322 -0.52 -9.73 -0.36 5.8e-21 Urinary 1,3-butadiene metabolite levels in smokers; BRCA trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21659725 chr3:3221576 CRBN 0.49 12.38 0.44 1.09e-31 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg23711669 chr6:146136114 FBXO30 0.77 17.6 0.57 8.16e-57 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.818 rs55825515 chr4:120486402 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.42 0.32 2.47e-16 Corneal astigmatism; BRCA cis rs7618501 0.699 rs2681780 chr3:49897830 C/T cg24110177 chr3:50126178 RBM5 -0.37 -9.93 -0.37 1.06e-21 Intelligence (multi-trait analysis); BRCA cis rs72627509 0.857 rs2227901 chr4:57798189 A/G cg26694713 chr4:57773883 REST -0.51 -9.91 -0.36 1.25e-21 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs1973993 0.691 rs1989141 chr1:96898520 C/T cg10631902 chr5:14652156 NA 0.59 21.2 0.64 6.24e-76 Weight; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg18402987 chr7:1209562 NA 0.82 11.85 0.42 1.95e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg06115741 chr20:33292138 TP53INP2 0.5 11.12 0.4 2.28e-26 Coronary artery disease; BRCA cis rs6714710 0.603 rs13023980 chr2:98502987 T/C cg26665480 chr2:98280029 ACTR1B 0.58 13.44 0.47 1.82e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg27170947 chr2:26402098 FAM59B -0.95 -16.86 -0.55 5.15e-53 Gut microbiome composition (summer); BRCA cis rs11955398 0.501 rs4700387 chr5:60036751 T/C cg02684056 chr5:59996105 DEPDC1B -0.37 -8.35 -0.31 4.29e-16 Intelligence (multi-trait analysis); BRCA cis rs780096 0.527 rs11127044 chr2:27740404 C/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.15 -0.31 1.86e-15 Total body bone mineral density; BRCA cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.27 0.49 2.73e-40 Motion sickness; BRCA cis rs778371 0.834 rs778364 chr2:233777859 A/G cg08000102 chr2:233561755 GIGYF2 0.51 9.72 0.36 6.27e-21 Schizophrenia; BRCA cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg00475322 chr7:917719 C7orf20 0.45 11.65 0.42 1.36e-28 Perceived unattractiveness to mosquitoes; BRCA cis rs7560272 0.588 rs4852965 chr2:73911169 T/C cg20560298 chr2:73613845 ALMS1 0.38 10.07 0.37 3.2e-22 Schizophrenia; BRCA trans rs11098499 0.754 rs2036856 chr4:120249288 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.4 0.38 1.72e-23 Corneal astigmatism; BRCA cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.54 -0.44 2.18e-32 Personality dimensions; BRCA cis rs875971 0.895 rs12531677 chr7:65769086 G/A cg11764359 chr7:65958608 NA -0.75 -16.63 -0.55 7.22e-52 Aortic root size; BRCA cis rs910316 0.789 rs175444 chr14:75601782 G/C cg23033748 chr14:75592666 NEK9 -0.37 -8.57 -0.32 7.59e-17 Height; BRCA trans rs11098499 0.909 rs73842633 chr4:120375464 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.21 0.43 5.69e-31 Corneal astigmatism; BRCA cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg01304814 chr3:48885189 PRKAR2A 0.75 7.89 0.3 1.36e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7727544 0.548 rs2069616 chr5:131408077 A/G cg14196790 chr5:131705035 SLC22A5 0.35 8.77 0.33 1.61e-17 Blood metabolite levels; BRCA cis rs35146811 0.735 rs1636975 chr7:99812089 A/G cg13334819 chr7:99746414 C7orf59 0.34 8.05 0.3 4.16e-15 Coronary artery disease; BRCA cis rs8114671 0.935 rs6060282 chr20:33767066 C/T cg07148914 chr20:33460835 GGT7 0.39 8.28 0.31 7.4e-16 Height; BRCA cis rs4595586 0.525 rs1400279 chr12:39343825 T/A cg26384229 chr12:38710491 ALG10B 0.54 11.37 0.41 2.1e-27 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg16339924 chr4:17578868 LAP3 0.66 16.9 0.56 3.1e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7267979 0.932 rs417110 chr20:25458297 T/C cg08601574 chr20:25228251 PYGB 0.34 8.36 0.31 3.94e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17401966 1.000 rs6700866 chr1:10306038 A/G cg03954927 chr1:10346856 KIF1B 0.43 12.76 0.45 2.22e-33 Hepatocellular carcinoma; BRCA cis rs1878931 0.597 rs2680221 chr16:3462595 A/G cg02880119 chr16:3481970 NA 0.48 8.65 0.32 4.15e-17 Body mass index (adult); BRCA cis rs17270561 0.609 rs9358872 chr6:25727517 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg06064525 chr11:970664 AP2A2 -0.48 -15.95 -0.53 1.8e-48 Alzheimer's disease (late onset); BRCA cis rs2032447 0.802 rs198853 chr6:26104096 T/C cg12310025 chr6:25882481 NA 0.49 10.84 0.39 2.98e-25 Intelligence (multi-trait analysis); BRCA cis rs17685 0.753 rs10476 chr7:75696420 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.38 8.41 0.32 2.58e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10504229 1.000 rs66479724 chr8:58188309 T/G cg24829409 chr8:58192753 C8orf71 -0.59 -12.09 -0.43 1.86e-30 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.875 rs2814877 chr6:146299763 C/G cg23711669 chr6:146136114 FBXO30 0.75 16.92 0.56 2.5e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg23018236 chr17:30244563 NA -0.52 -9.47 -0.35 5.47e-20 Hip circumference adjusted for BMI; BRCA cis rs7703051 0.585 rs918623 chr5:74596682 A/C cg19683494 chr5:74908142 NA 0.48 8.32 0.31 5.4e-16 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; BRCA trans rs9325144 0.671 rs7486919 chr12:38767997 A/G cg23762105 chr12:34175262 ALG10 0.36 8.45 0.32 2.02e-16 Morning vs. evening chronotype; BRCA cis rs7903847 0.602 rs7916665 chr10:99157573 T/G cg20016023 chr10:99160130 RRP12 -0.26 -8.46 -0.32 1.77e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs7264396 0.790 rs6121018 chr20:34249060 C/A cg23207816 chr20:34252616 CPNE1;RBM12 0.39 8.25 0.31 9.01e-16 Total cholesterol levels; BRCA cis rs11105298 1.000 rs11105298 chr12:89876143 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.57 9.69 0.36 8.1899999999999992e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs700651 0.789 rs10184395 chr2:198894285 G/A cg00792783 chr2:198669748 PLCL1 0.38 8.71 0.33 2.5e-17 Intracranial aneurysm; BRCA cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg06697600 chr4:7070879 GRPEL1 -0.55 -10.95 -0.4 1.08e-25 Monocyte percentage of white cells; BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg03609598 chr5:56110824 MAP3K1 -0.48 -7.96 -0.3 7.6e-15 Initial pursuit acceleration; BRCA cis rs6598955 0.671 rs17163746 chr1:26564230 C/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs17376456 0.877 rs10078194 chr5:93364310 A/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.59 7.87 0.3 1.47e-14 Diabetic retinopathy; BRCA cis rs1008375 0.933 rs6449324 chr4:17694880 G/C cg02297831 chr4:17616191 MED28 0.35 8.29 0.31 6.6e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.75 15.41 0.52 8.18e-46 Smoking behavior; BRCA cis rs2997447 0.655 rs12094933 chr1:26374779 T/C cg19633962 chr1:26362018 EXTL1 -0.53 -9.45 -0.35 6.24e-20 QRS complex (12-leadsum); BRCA cis rs6910061 0.830 rs6456830 chr6:11093298 G/A cg27233058 chr6:11094804 LOC221710 0.5 8.43 0.32 2.33e-16 Diabetic kidney disease; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg07092213 chr7:1199455 ZFAND2A -0.41 -8.24 -0.31 1.01e-15 Longevity;Endometriosis; BRCA cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.653 rs10414983 chr19:37665732 T/C cg23950597 chr19:37808831 NA -0.66 -10.28 -0.38 4.82e-23 Coronary artery calcification; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg00990874 chr7:1149470 C7orf50 -0.63 -13.42 -0.47 2.38e-36 Bronchopulmonary dysplasia; BRCA cis rs7945705 0.869 rs11042154 chr11:9029700 A/G cg12365402 chr11:9010492 NRIP3 -0.43 -9.2 -0.34 5.11e-19 Hemoglobin concentration; BRCA cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg26647111 chr11:31128758 NA -0.45 -9.87 -0.36 1.72e-21 Red blood cell count; BRCA cis rs9400271 0.632 rs6899616 chr6:109584885 A/G cg01475377 chr6:109611718 NA -0.44 -10.44 -0.38 1.1e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg05623727 chr3:50126028 RBM5 -0.49 -12.16 -0.43 9.5e-31 Body mass index; BRCA cis rs7727544 0.735 rs4705933 chr5:131678412 G/A cg07395648 chr5:131743802 NA -0.37 -9.14 -0.34 7.96e-19 Blood metabolite levels; BRCA cis rs17685 0.753 rs2302438 chr7:75677065 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.43 -9.8 -0.36 3.11e-21 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs11098499 0.909 rs11723757 chr4:120299669 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.06 0.3 3.83e-15 Corneal astigmatism; BRCA cis rs6460942 0.778 rs74993124 chr7:12462917 A/G cg20607287 chr7:12443886 VWDE -0.51 -8.04 -0.3 4.52e-15 Coronary artery disease; BRCA cis rs4363385 0.782 rs2152993 chr1:152991695 C/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.88 -0.33 6.73e-18 Inflammatory skin disease; BRCA cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg23788917 chr6:8435910 SLC35B3 0.49 10.73 0.39 8.29e-25 Motion sickness; BRCA trans rs9858542 0.951 rs1800668 chr3:49395757 G/A cg21659725 chr3:3221576 CRBN -0.45 -9.78 -0.36 3.79e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg13319975 chr6:146136371 FBXO30 0.58 12.6 0.45 1.15e-32 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 0.896 rs6794258 chr3:134344505 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.38 -0.31 3.41e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2901460 0.509 rs17573253 chr2:62101915 C/T cg02183531 chr2:62113199 CCT4 0.45 9.14 0.34 8.38e-19 Mean corpuscular volume; BRCA cis rs724568 0.546 rs10188512 chr2:67940962 C/T cg17945962 chr2:67939740 NA -0.39 -10.58 -0.39 3.13e-24 Major depressive disorder (broad); BRCA trans rs11098499 0.908 rs11729050 chr4:120300066 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg13395646 chr4:1353034 KIAA1530 -0.51 -9.1 -0.34 1.09e-18 Obesity-related traits; BRCA cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.81 0.6 3.96e-63 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1882538 0.564 rs10488164 chr7:133106199 A/G cg10665199 chr7:133106180 EXOC4 0.47 10.33 0.38 3.21e-23 Intelligence (multi-trait analysis); BRCA cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg20818283 chr2:191399100 TMEM194B -0.39 -9.08 -0.34 1.33e-18 Pulse pressure; BRCA cis rs7267979 1.000 rs2500424 chr20:25391969 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.07 -0.3 3.6e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs921968 0.541 rs585185 chr2:219457741 G/A cg10223061 chr2:219282414 VIL1 -0.27 -8.08 -0.3 3.13e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg24101359 chr6:42928495 GNMT 0.55 12.63 0.45 8.46e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg00339695 chr16:24857497 SLC5A11 0.54 11.57 0.42 3.12e-28 Intelligence (multi-trait analysis); BRCA cis rs887829 0.569 rs4663333 chr2:234655303 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.29 -0.31 6.77e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg18230493 chr5:56204884 C5orf35 -0.73 -14.66 -0.5 3.79e-42 Initial pursuit acceleration; BRCA cis rs72781680 0.898 rs55657921 chr2:24008091 C/G cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs17401966 0.838 rs12738317 chr1:10419663 C/T cg03954927 chr1:10346856 KIF1B 0.43 13.57 0.47 4.97e-37 Hepatocellular carcinoma; BRCA cis rs701145 0.585 rs6440935 chr3:153816976 A/T cg17054900 chr3:154042577 DHX36 0.53 9.04 0.34 1.88e-18 Coronary artery disease; BRCA cis rs17401966 0.558 rs6541090 chr1:10402842 A/G cg03954927 chr1:10346856 KIF1B 0.34 10.34 0.38 2.83e-23 Hepatocellular carcinoma; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg13047869 chr3:10149882 C3orf24 0.6 12.77 0.45 1.99e-33 Alzheimer's disease; BRCA cis rs7659604 0.537 rs6815973 chr4:122663430 A/T cg19748678 chr4:122722346 EXOSC9 -0.55 -10.58 -0.39 3.26e-24 Type 2 diabetes; BRCA cis rs9388451 0.626 rs1268074 chr6:126107791 G/C cg05901451 chr6:126070800 HEY2 -0.53 -14.02 -0.49 3.81e-39 Brugada syndrome; BRCA cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg00074818 chr8:8560427 CLDN23 0.38 8.35 0.31 4.17e-16 Obesity-related traits; BRCA cis rs2439831 0.850 rs3742982 chr15:44176681 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.5 9.45 0.35 6.23e-20 Lung cancer in ever smokers; BRCA cis rs4302748 0.862 rs11772400 chr7:36186371 G/C cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs6782228 0.606 rs2712417 chr3:128345179 A/G cg16766828 chr3:128327626 NA -0.42 -9.51 -0.35 3.95e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs3806843 0.868 rs2262573 chr5:140123627 T/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.3 0.35 2.21e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs1691799 0.899 rs1168301 chr12:66736771 C/T cg16791601 chr12:66731901 HELB -0.63 -16.85 -0.55 5.7e-53 White blood cell count (basophil); BRCA cis rs7098414 0.511 rs4934134 chr10:82160582 C/T cg01528321 chr10:82214614 TSPAN14 0.69 14.59 0.5 7.96e-42 Post bronchodilator FEV1; BRCA cis rs2762353 0.902 rs1165199 chr6:25809087 C/T cg03517284 chr6:25882590 NA -0.47 -10.71 -0.39 9.52e-25 Blood metabolite levels; BRCA cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg00409905 chr10:38381863 ZNF37A -0.49 -10.07 -0.37 3.01e-22 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.91e-24 Motion sickness; BRCA cis rs2836974 0.899 rs35774464 chr21:40580169 G/A cg11644478 chr21:40555479 PSMG1 0.76 15.53 0.52 2.29e-46 Cognitive function; BRCA cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs629535 0.862 rs662725 chr8:70029616 C/T cg21567404 chr3:27674614 NA 1.0 20.96 0.64 1.17e-74 Dupuytren's disease; BRCA cis rs7904368 0.754 rs7076955 chr10:16852781 G/A cg23933602 chr10:16859644 RSU1 0.54 8.76 0.33 1.77e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs10992471 0.528 rs10117627 chr9:95203953 G/A cg14631576 chr9:95140430 CENPP -0.34 -8.48 -0.32 1.51e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs10751667 0.857 rs7481221 chr11:966813 G/C cg10932868 chr11:921992 NA 0.49 12.38 0.44 1.09e-31 Alzheimer's disease (late onset); BRCA cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg15782153 chr7:917662 C7orf20 0.4 9.42 0.35 7.84e-20 Perceived unattractiveness to mosquitoes; BRCA cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.41 8.41 0.32 2.66e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs9503598 0.636 rs6596977 chr6:3466254 G/A cg00476032 chr6:3446245 SLC22A23 0.38 9.29 0.34 2.47e-19 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA trans rs7980799 0.682 rs1351682 chr12:33598775 G/A cg26384229 chr12:38710491 ALG10B -0.49 -10.62 -0.39 2.29e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA trans rs11098499 0.820 rs28394116 chr4:120524283 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.3 0.31 6e-16 Corneal astigmatism; BRCA cis rs2180341 0.842 rs6569476 chr6:127553539 G/A cg24812749 chr6:127587940 RNF146 0.8 15.44 0.52 6.04e-46 Breast cancer; BRCA cis rs4268898 0.760 rs7597919 chr2:24563646 A/G cg06627628 chr2:24431161 ITSN2 0.4 8.55 0.32 9.25e-17 Asthma; BRCA cis rs853679 0.542 rs6934769 chr6:28090931 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.02 -0.3 5.22e-15 Depression; BRCA trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA cis rs1832871 0.711 rs9459954 chr6:158709345 G/T cg07165851 chr6:158734300 TULP4 0.63 13.03 0.46 1.37e-34 Height; BRCA cis rs4363385 0.818 rs10788852 chr1:153000491 C/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.0 -0.34 2.49e-18 Inflammatory skin disease; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg15112475 chr7:1198522 ZFAND2A -0.41 -9.62 -0.36 1.48e-20 Longevity;Endometriosis; BRCA cis rs7772486 0.720 rs702320 chr6:146006654 G/A cg05347473 chr6:146136440 FBXO30 -0.41 -8.12 -0.31 2.36e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.617 rs4841072 chr8:8791253 C/A cg06636001 chr8:8085503 FLJ10661 -0.55 -12.09 -0.43 1.86e-30 Mood instability; BRCA cis rs7729447 0.813 rs4867470 chr5:32692536 C/A cg16267343 chr5:32710456 NPR3 0.44 9.19 0.34 5.38e-19 Blood pressure; BRCA cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg09184832 chr6:79620586 NA -0.53 -11.74 -0.42 5.65e-29 Intelligence (multi-trait analysis); BRCA cis rs6728642 0.908 rs7588921 chr2:98021001 C/T cg26665480 chr2:98280029 ACTR1B -0.55 -8.32 -0.31 5.48e-16 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs13082711 0.911 rs73046191 chr3:27454398 T/A cg02860705 chr3:27208620 NA 0.53 10.65 0.39 1.65e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs78456975 0.739 rs13405352 chr2:1518726 C/T cg12573674 chr2:1569213 NA -0.48 -9.47 -0.35 5.23e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs8005677 0.962 rs8003934 chr14:23401142 A/G cg01529538 chr14:23388837 RBM23 0.42 11.23 0.41 7.61e-27 Cognitive ability (multi-trait analysis); BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg03188948 chr7:1209495 NA 0.87 11.85 0.42 2.11e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg19729930 chr2:74357872 NA 0.59 14.48 0.5 2.66e-41 Gestational age at birth (maternal effect); BRCA cis rs12477438 0.508 rs2516832 chr2:99771268 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg11833968 chr6:79620685 NA -0.4 -8.9 -0.33 5.7e-18 Intelligence (multi-trait analysis); BRCA cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg26528668 chr16:1614120 IFT140 0.37 8.6 0.32 6.11e-17 Coronary artery disease; BRCA cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg18876405 chr7:65276391 NA -0.57 -13.53 -0.47 7.72e-37 Aortic root size; BRCA trans rs61931739 0.534 rs6488189 chr12:33995865 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.37 0.35 1.25e-19 Morning vs. evening chronotype; BRCA cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg26874164 chr19:58962979 ZNF324B 0.47 10.05 0.37 3.67e-22 Uric acid clearance; BRCA cis rs7927771 0.524 rs11039345 chr11:47720228 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.45 0.35 6.42e-20 Subjective well-being; BRCA cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg07606381 chr6:8435919 SLC35B3 0.64 14.06 0.49 2.58e-39 Motion sickness; BRCA cis rs4566357 0.615 rs12474622 chr2:227912793 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -8.08 -0.3 3.32e-15 Coronary artery disease; BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg03354898 chr7:1950403 MAD1L1 -0.4 -8.43 -0.32 2.26e-16 Bipolar disorder and schizophrenia; BRCA cis rs9814567 1.000 rs1534025 chr3:134313304 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.63 0.32 4.73e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10267417 0.603 rs34087364 chr7:19860293 A/C cg05791153 chr7:19748676 TWISTNB 0.5 9.53 0.35 3.2e-20 Night sleep phenotypes; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg08470875 chr2:26401718 FAM59B 0.76 11.99 0.43 5.11e-30 Gut microbiome composition (summer); BRCA cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg04450456 chr4:17643702 FAM184B 0.37 10.91 0.4 1.54e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9325144 0.560 rs11182952 chr12:38636278 C/A cg13010199 chr12:38710504 ALG10B -0.39 -8.9 -0.33 5.76e-18 Morning vs. evening chronotype; BRCA cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg24642439 chr20:33292090 TP53INP2 0.52 11.36 0.41 2.35e-27 Glomerular filtration rate (creatinine); BRCA cis rs3733585 0.673 rs7376948 chr4:9954708 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.51e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg09184832 chr6:79620586 NA -0.48 -10.52 -0.38 5.72e-24 Intelligence (multi-trait analysis); BRCA trans rs2018683 0.584 rs4722880 chr7:28999197 C/T cg19402173 chr7:128379420 CALU -0.49 -11.79 -0.42 3.45e-29 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs12611088 0.571 rs7252955 chr19:44021766 A/T cg15012607 chr19:44012195 ETHE1 -0.35 -9.13 -0.34 8.66e-19 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg22875332 chr1:76189707 ACADM 0.68 14.4 0.5 6.06e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7617773 0.817 rs11707606 chr3:48237087 A/C cg11946769 chr3:48343235 NME6 0.68 14.11 0.49 1.58e-39 Coronary artery disease; BRCA cis rs36051895 0.632 rs11791281 chr9:5172540 G/A cg02405213 chr9:5042618 JAK2 -0.49 -9.57 -0.35 2.24e-20 Pediatric autoimmune diseases; BRCA cis rs208520 0.690 rs1580430 chr6:66715162 T/A cg07460842 chr6:66804631 NA 0.92 18.29 0.59 2.09e-60 Exhaled nitric oxide output; BRCA cis rs11190604 1.000 rs4919471 chr10:102299239 A/G cg07080220 chr10:102295463 HIF1AN 0.63 14.63 0.5 5.31e-42 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg05347473 chr6:146136440 FBXO30 0.43 8.76 0.33 1.7e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6723226 0.721 rs10172510 chr2:32620888 A/G cg02381751 chr2:32503542 YIPF4 0.46 10.03 0.37 4.36e-22 Intelligence (multi-trait analysis); BRCA cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg13114125 chr14:105738426 BRF1 -0.46 -10.04 -0.37 4.16e-22 Mean platelet volume;Platelet distribution width; BRCA cis rs9814567 1.000 rs7426847 chr3:134267519 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg16339924 chr4:17578868 LAP3 0.57 13.93 0.48 1.08e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2625529 0.824 rs7170461 chr15:72218599 C/A cg16672083 chr15:72433130 SENP8 -0.83 -17.2 -0.56 8.64e-55 Red blood cell count; BRCA cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg22508957 chr16:3507546 NAT15 0.47 11.54 0.42 4.05e-28 Tuberculosis; BRCA cis rs528301 0.833 rs340498 chr2:45135885 A/C cg02372786 chr2:45167549 SIX3 -0.45 -10.86 -0.39 2.41e-25 Alcohol and nicotine co-dependence; BRCA trans rs6598955 0.671 rs11247900 chr1:26612460 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.69 -16.68 -0.55 3.79e-52 Obesity-related traits; BRCA cis rs1595825 0.891 rs73056823 chr2:198769788 T/C cg19156104 chr2:198669113 PLCL1 -0.41 -7.82 -0.3 2.17e-14 Ulcerative colitis; BRCA cis rs10193935 0.901 rs17029344 chr2:42444287 T/C cg27598129 chr2:42591480 NA -0.94 -15.2 -0.52 8.77e-45 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg22467129 chr15:76604101 ETFA -0.39 -8.79 -0.33 1.34e-17 Blood metabolite levels; BRCA trans rs6479891 1.000 rs9414780 chr10:65001433 G/T cg14819942 chr15:35414228 NA 0.35 8.64 0.32 4.39e-17 Arthritis (juvenile idiopathic); BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.59 -10.84 -0.39 2.98e-25 Renal function-related traits (BUN); BRCA cis rs77633900 0.614 rs280012 chr15:76974854 G/T cg21673338 chr15:77095150 SCAPER -0.53 -9.74 -0.36 5.55e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs3784262 0.669 rs3742960 chr15:58248088 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.21 -0.37 9.27e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs17092148 1.000 rs60789653 chr20:33447162 G/A cg16810054 chr20:33298113 TP53INP2 0.47 10.3 0.38 3.91e-23 Neuroticism; BRCA cis rs2562152 0.706 rs216598 chr16:108585 T/C cg02949481 chr16:131562 MPG 0.58 9.32 0.35 1.8e-19 Glioblastoma; BRCA cis rs9394152 0.845 rs9366823 chr6:33471059 C/T cg13560919 chr6:33536144 NA 0.62 12.76 0.45 2.26e-33 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg08470875 chr2:26401718 FAM59B -0.64 -9.57 -0.35 2.34e-20 Gut microbiome composition (summer); BRCA trans rs12517041 1.000 rs1820748 chr5:23323355 T/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.95 -0.3 8.47e-15 Calcium levels; BRCA cis rs2380220 0.606 rs7747776 chr6:96005852 C/T cg15832292 chr6:96025679 MANEA 0.51 8.67 0.32 3.66e-17 Behavioural disinhibition (generation interaction); BRCA cis rs6543140 0.572 rs17027173 chr2:103057043 G/A cg04239558 chr2:103089729 SLC9A4 0.33 7.97 0.3 7.05e-15 Blood protein levels; BRCA cis rs12545109 0.837 rs1437277 chr8:57356734 T/C cg09654669 chr8:57350985 NA -0.43 -8.14 -0.31 2.01e-15 Obesity-related traits; BRCA cis rs8141529 0.748 rs5762874 chr22:29269658 C/G cg15103426 chr22:29168792 CCDC117 0.52 12.36 0.44 1.34e-31 Lymphocyte counts; BRCA cis rs10504229 0.683 rs72649188 chr8:58108829 A/G cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs4722166 0.541 rs1800795 chr7:22766645 C/G cg05472934 chr7:22766657 IL6 0.61 15.55 0.52 1.79e-46 Lung cancer; BRCA cis rs72772090 0.539 rs114006288 chr5:96118004 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8114671 0.836 rs6058154 chr20:33585834 C/T cg24642439 chr20:33292090 TP53INP2 -0.43 -8.65 -0.32 4.21e-17 Height; BRCA cis rs35110281 0.720 rs162392 chr21:44941406 A/G cg21573476 chr21:45109991 RRP1B -0.36 -9.06 -0.34 1.56e-18 Mean corpuscular volume; BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg00166722 chr3:10149974 C3orf24 0.67 13.38 0.47 3.6e-36 Alzheimer's disease; BRCA cis rs9868809 0.505 rs9882549 chr3:48749358 C/T cg07636037 chr3:49044803 WDR6 -0.6 -8.69 -0.33 2.99e-17 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7246657 0.943 rs10415024 chr19:37814724 A/G cg18154014 chr19:37997991 ZNF793 0.56 10.74 0.39 7.29e-25 Coronary artery calcification; BRCA cis rs2276314 0.857 rs28431958 chr18:33578401 T/G cg19628046 chr18:33552617 C18orf21 0.56 11.05 0.4 4.43e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7560272 0.538 rs2012574 chr2:73928366 G/C cg20560298 chr2:73613845 ALMS1 0.35 8.96 0.33 3.41e-18 Schizophrenia; BRCA cis rs6840360 0.593 rs7654294 chr4:152690975 T/C cg22705602 chr4:152727874 NA -0.38 -10.5 -0.38 6.91e-24 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs2255766 chr21:46683777 C/T cg06618935 chr21:46677482 NA -0.38 -8.49 -0.32 1.48e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs10465746 0.570 rs1886769 chr1:84471134 C/A cg10977910 chr1:84465055 TTLL7 0.54 11.17 0.4 1.37e-26 Obesity-related traits; BRCA cis rs10838687 0.932 rs4752973 chr11:47269159 T/C cg25783544 chr11:47291846 MADD 0.43 8.38 0.31 3.44e-16 Proinsulin levels; BRCA cis rs12497850 0.931 rs11705888 chr3:48817289 T/C cg06212747 chr3:49208901 KLHDC8B 0.48 9.83 0.36 2.56e-21 Parkinson's disease; BRCA cis rs72781680 0.948 rs113530757 chr2:24142500 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.93e-19 Lymphocyte counts; BRCA cis rs17376456 0.825 rs17372649 chr5:93126096 C/G cg21475434 chr5:93447410 FAM172A 0.68 8.8 0.33 1.26e-17 Diabetic retinopathy; BRCA cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.85 -0.36 2.12e-21 Developmental language disorder (linguistic errors); BRCA cis rs2011503 0.825 rs4808932 chr19:19358819 C/T cg11584989 chr19:19387371 SF4 0.55 12.27 0.44 3.08e-31 Bipolar disorder; BRCA trans rs11098499 0.954 rs17046116 chr4:120387259 G/A cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs9399135 0.967 rs2183709 chr6:135377091 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.35 0.44 1.45e-31 Red blood cell count; BRCA cis rs7267979 1.000 rs2500418 chr20:25382268 C/T cg08601574 chr20:25228251 PYGB -0.39 -9.01 -0.34 2.34e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs344364 0.511 rs1742468 chr16:1950243 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -9.78 -0.36 3.77e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs2836950 0.520 rs1980407 chr21:40543961 T/C cg06238570 chr21:40685208 BRWD1 -0.39 -7.94 -0.3 9.01e-15 Menarche (age at onset); BRCA cis rs17604090 0.793 rs66956566 chr7:29688702 A/G cg19413766 chr7:29689036 LOC646762 -0.5 -8.12 -0.31 2.43e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs3784262 0.527 rs4646557 chr15:58354697 T/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -9.99 -0.37 6.16e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7666738 1.000 rs35066600 chr4:98991066 C/A cg03676636 chr4:99064102 C4orf37 0.23 8.2 0.31 1.31e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05901451 chr6:126070800 HEY2 -0.56 -15.2 -0.52 9.59e-45 Brugada syndrome; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg16606324 chr3:10149918 C3orf24 0.57 10.13 0.37 1.86e-22 Alzheimer's disease; BRCA cis rs7208859 0.623 rs9895785 chr17:29107708 C/T cg13385521 chr17:29058706 SUZ12P -0.75 -11.68 -0.42 1.05e-28 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6840258 1.000 rs56395939 chr4:87963633 T/G cg08197287 chr4:87952173 AFF1 -0.47 -9.25 -0.34 3.45e-19 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs3925075 1.000 rs9673405 chr16:31347599 A/C cg02846316 chr16:31340340 ITGAM 0.53 13.04 0.46 1.2e-34 IgA nephropathy; BRCA cis rs10751667 0.600 rs1128413 chr11:1010694 C/T cg20946044 chr11:1010712 AP2A2 -0.37 -7.94 -0.3 9.33e-15 Alzheimer's disease (late onset); BRCA cis rs2153535 0.580 rs2327067 chr6:8518482 C/G cg21535247 chr6:8435926 SLC35B3 0.41 9.36 0.35 1.36e-19 Motion sickness; BRCA cis rs724568 0.509 rs10203976 chr2:67941638 T/G cg17945962 chr2:67939740 NA -0.39 -10.56 -0.39 3.9e-24 Major depressive disorder (broad); BRCA cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg24549020 chr5:56110836 MAP3K1 0.64 13.06 0.46 9.94e-35 Initial pursuit acceleration; BRCA cis rs17376456 0.877 rs9314101 chr5:93461593 A/T cg09848695 chr5:92956644 FAM172A;MIR2277 0.61 8.14 0.31 2.1e-15 Diabetic retinopathy; BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg21724239 chr8:58056113 NA 0.57 9.29 0.34 2.48e-19 Developmental language disorder (linguistic errors); BRCA trans rs4332037 0.624 rs11764337 chr7:1892309 A/G cg25206134 chr2:45395956 NA -0.53 -9.1 -0.34 1.16e-18 Bipolar disorder; BRCA cis rs2880765 0.566 rs11630381 chr15:86012503 A/G cg19183879 chr15:85880815 NA -0.32 -7.85 -0.3 1.7e-14 Coronary artery disease; BRCA cis rs2239547 0.522 rs9842974 chr3:53011050 C/A cg11645453 chr3:52864694 ITIH4 0.45 11.26 0.41 5.99e-27 Schizophrenia; BRCA cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg11301795 chr4:187892539 NA -0.26 -8.71 -0.33 2.57e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.3 -0.31 6.42e-16 Bipolar disorder; BRCA cis rs2070488 0.636 rs2284817 chr3:38510388 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.55 12.44 0.44 6e-32 Electrocardiographic conduction measures; BRCA cis rs1163251 0.837 rs595283 chr1:120247887 C/G cg19096424 chr1:120255104 PHGDH -0.46 -10.58 -0.39 3.24e-24 Blood metabolite levels; BRCA cis rs9420 0.925 rs10896636 chr11:57448032 C/G cg19752551 chr11:57585705 CTNND1 -0.5 -12.23 -0.44 4.91e-31 Schizophrenia; BRCA cis rs7254114 0.578 rs12980863 chr19:11309871 C/T cg02815516 chr19:11306319 KANK2 -0.34 -10.18 -0.37 1.14e-22 Immature fraction of reticulocytes; BRCA trans rs8073060 0.614 rs72829932 chr17:34055935 A/G cg19694781 chr19:47549865 TMEM160 1.02 19.12 0.6 9e-65 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs875971 0.895 rs7788984 chr7:65915616 A/G cg12463550 chr7:65579703 CRCP 0.37 7.92 0.3 1.03e-14 Aortic root size; BRCA cis rs17095355 0.818 rs12571549 chr10:111770013 G/A cg00817464 chr10:111662876 XPNPEP1 -0.41 -9.32 -0.35 1.86e-19 Biliary atresia; BRCA cis rs4660306 0.961 rs4660864 chr1:45966582 C/T cg24296786 chr1:45957014 TESK2 0.41 8.24 0.31 9.85e-16 Homocysteine levels; BRCA trans rs35110281 0.607 rs4819212 chr21:44977455 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.46 10.02 0.37 4.87e-22 Mean corpuscular volume; BRCA cis rs922692 0.715 rs2277546 chr15:79083376 C/A cg04896959 chr15:78267971 NA 0.37 8.66 0.32 3.84e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg08822215 chr16:89438651 ANKRD11 -0.47 -10.61 -0.39 2.4e-24 Multiple myeloma (IgH translocation); BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.25 0.41 6.58e-27 Platelet count; BRCA cis rs477692 0.647 rs11016853 chr10:131443990 A/G cg24747557 chr10:131355152 MGMT 0.33 8.36 0.31 3.93e-16 Response to temozolomide; BRCA cis rs6835098 0.961 rs17322893 chr4:174122556 A/G cg08422745 chr4:174089978 GALNT7 0.81 15.23 0.52 6.2e-45 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.6 0.57 8e-57 Electrocardiographic conduction measures; BRCA trans rs208520 1.000 rs9453663 chr6:66976077 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.68 11.68 0.42 1.01e-28 Exhaled nitric oxide output; BRCA cis rs12497850 0.931 rs6446205 chr3:49035211 C/T cg07636037 chr3:49044803 WDR6 0.98 29.1 0.75 3.3e-119 Parkinson's disease; BRCA cis rs875971 0.862 rs6960446 chr7:65733259 A/G cg11764359 chr7:65958608 NA -0.75 -16.67 -0.55 4.55e-52 Aortic root size; BRCA cis rs1534166 0.647 rs9876158 chr3:133508300 T/C cg11941060 chr3:133502564 NA 0.34 7.98 0.3 6.92e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs10870270 1.000 rs72636963 chr10:133771271 C/T cg17892150 chr10:133769511 PPP2R2D -0.71 -15.26 -0.52 4.88e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7927592 0.956 rs11228269 chr11:68289796 A/G cg20283391 chr11:68216788 NA -0.45 -9.08 -0.34 1.36e-18 Total body bone mineral density; BRCA cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg04607235 chr12:12878440 APOLD1 0.69 10.71 0.39 9.63e-25 Systemic lupus erythematosus; BRCA cis rs3862030 0.720 rs7341995 chr10:104223831 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -13.01 -0.46 1.63e-34 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs13136331 0.532 rs2615492 chr4:88569491 A/G cg22416721 chr4:88570574 DMP1 -0.6 -14.85 -0.51 4.7e-43 Sitting height ratio; BRCA cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg02734326 chr4:10020555 SLC2A9 0.41 8.96 0.33 3.56e-18 Bone mineral density; BRCA cis rs380904 0.552 rs10099003 chr8:144645460 C/T cg13399544 chr8:144649678 C8orf73 -0.34 -7.85 -0.3 1.82e-14 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg06550200 chr5:1325588 CLPTM1L -0.62 -13.59 -0.47 3.95e-37 Lung cancer; BRCA cis rs7647973 0.588 rs4855848 chr3:49653457 C/T cg03060546 chr3:49711283 APEH 0.6 10.21 0.37 8.9e-23 Menarche (age at onset); BRCA cis rs3125734 0.582 rs7904465 chr10:64002393 G/A cg09941381 chr10:64027924 RTKN2 -0.28 -7.94 -0.3 8.91e-15 Rheumatoid arthritis; BRCA cis rs2637030 0.559 rs256095 chr5:52972669 C/T cg06476337 chr5:52856530 NDUFS4 -0.35 -7.83 -0.3 2.05e-14 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg22906224 chr7:99728672 NA 0.49 9.22 0.34 4.41e-19 Coronary artery disease; BRCA cis rs8062405 1.000 rs55830740 chr16:28847149 G/C cg16576597 chr16:28551801 NUPR1 0.3 8.44 0.32 2.14e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs8014204 0.762 rs7144654 chr14:75298637 A/G cg06637938 chr14:75390232 RPS6KL1 0.42 8.69 0.32 3.15e-17 Caffeine consumption; BRCA cis rs832540 0.931 rs702679 chr5:56221328 A/G cg24531977 chr5:56204891 C5orf35 -0.43 -8.91 -0.33 5.37e-18 Coronary artery disease; BRCA cis rs12620999 0.774 rs6711726 chr2:238101795 C/T cg23555395 chr2:238036564 NA -0.37 -8.62 -0.32 5.07e-17 Systemic lupus erythematosus; BRCA cis rs933688 1.000 rs12655973 chr5:90736537 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 20.92 0.64 1.93e-74 Smoking behavior; BRCA cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg11890956 chr21:40555474 PSMG1 -0.86 -22.18 -0.66 2.73e-81 Cognitive function; BRCA cis rs17270561 0.609 rs9356984 chr6:25725481 C/T cg16482183 chr6:26056742 HIST1H1C -0.42 -8.16 -0.31 1.76e-15 Iron status biomarkers; BRCA trans rs561341 1.000 rs510264 chr17:30323414 A/G cg20587970 chr11:113659929 NA -1.35 -24.74 -0.7 2.76e-95 Hip circumference adjusted for BMI; BRCA cis rs425277 1.000 rs262672 chr1:2080813 G/T cg24578937 chr1:2090814 PRKCZ 0.57 17.81 0.58 6.82e-58 Height; BRCA cis rs9811920 0.638 rs796977 chr3:99549723 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 8.44 0.32 2.05e-16 Axial length; BRCA cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06544989 chr22:39130855 UNC84B -0.35 -8.43 -0.32 2.36e-16 Menopause (age at onset); BRCA cis rs9814567 0.806 rs55835132 chr3:134325256 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.52 -0.32 1.18e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2204008 0.837 rs55962152 chr12:38234281 G/A cg26384229 chr12:38710491 ALG10B 0.69 15.68 0.53 4.01e-47 Bladder cancer; BRCA cis rs4073582 0.595 rs10896104 chr11:66001869 C/T cg16950941 chr11:66035639 RAB1B 0.45 11.83 0.42 2.5e-29 Gout; BRCA cis rs17345786 1.000 rs17345786 chr3:101318318 A/C cg11279151 chr3:101281821 RG9MTD1 0.5 10.77 0.39 5.89e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.47 0.38 8.48e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs11098499 0.954 rs10008459 chr4:120394231 T/C cg25214090 chr10:38739885 LOC399744 0.56 12.83 0.45 1.08e-33 Corneal astigmatism; BRCA trans rs11098499 0.820 rs2389885 chr4:120533931 C/T cg25214090 chr10:38739885 LOC399744 0.54 10.99 0.4 7.59e-26 Corneal astigmatism; BRCA cis rs701145 0.585 rs938989 chr3:153788222 A/G cg17054900 chr3:154042577 DHX36 0.56 8.24 0.31 9.8e-16 Coronary artery disease; BRCA cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg11663144 chr21:46675770 NA -0.6 -13.84 -0.48 2.6e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11039798 0.557 rs4436575 chr11:48398894 T/C cg15704280 chr7:45808275 SEPT13 -0.57 -9.65 -0.36 1.14e-20 Axial length; BRCA cis rs7772486 0.790 rs1832362 chr6:146179955 C/T cg23711669 chr6:146136114 FBXO30 0.72 17.38 0.57 1.09e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs992157 0.965 rs62182826 chr2:219148723 C/A cg00012203 chr2:219082015 ARPC2 0.59 12.31 0.44 2.23e-31 Colorectal cancer; BRCA cis rs738322 0.967 rs133018 chr22:38572761 G/A cg25457927 chr22:38595422 NA -0.31 -11.83 -0.42 2.46e-29 Cutaneous nevi; BRCA cis rs992157 0.560 rs12987130 chr2:219104990 T/C cg00012203 chr2:219082015 ARPC2 -0.57 -12.11 -0.43 1.56e-30 Colorectal cancer; BRCA cis rs4728302 0.869 rs10224683 chr7:133590937 A/G cg07491979 chr7:133331646 EXOC4 -0.36 -7.87 -0.3 1.58e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs6879260 1.000 rs729568 chr5:179732350 C/T cg23248424 chr5:179741104 GFPT2 0.64 13.59 0.47 3.96e-37 Height; BRCA cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg22875332 chr1:76189707 ACADM 0.69 14.93 0.51 1.77e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2835872 0.758 rs1787396 chr21:39036487 A/C cg06728970 chr21:39037746 KCNJ6 0.45 12.83 0.45 1.14e-33 Electroencephalographic traits in alcoholism; BRCA cis rs735539 0.645 rs1052209 chr13:21216850 C/T cg27499820 chr13:21296301 IL17D 0.44 8.44 0.32 2.19e-16 Dental caries; BRCA cis rs559928 0.606 rs11231710 chr11:63925743 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 11.34 0.41 2.88e-27 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs950027 0.787 rs1153845 chr15:45724729 C/T cg21132104 chr15:45694354 SPATA5L1 -0.39 -7.9 -0.3 1.2e-14 Response to fenofibrate (adiponectin levels); BRCA cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg10932868 chr11:921992 NA 0.48 12.32 0.44 1.92e-31 Alzheimer's disease (late onset); BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg00166722 chr3:10149974 C3orf24 0.64 11.27 0.41 5.44e-27 Alzheimer's disease; BRCA cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg24531977 chr5:56204891 C5orf35 -0.88 -19.08 -0.6 1.37e-64 Initial pursuit acceleration; BRCA cis rs9815354 0.812 rs73071239 chr3:41992610 C/A cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg02734326 chr4:10020555 SLC2A9 0.35 7.87 0.3 1.47e-14 Bone mineral density; BRCA trans rs7824557 0.591 rs2043510 chr8:11225168 G/A cg06636001 chr8:8085503 FLJ10661 -0.45 -9.01 -0.34 2.31e-18 Retinal vascular caliber; BRCA cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 0.609 rs4712961 chr6:25727334 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg18132916 chr6:79620363 NA -0.47 -10.73 -0.39 8.25e-25 Intelligence (multi-trait analysis); BRCA cis rs870825 0.616 rs28497285 chr4:185629169 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg07917127 chr4:99064746 C4orf37 0.44 8.1 0.31 2.86e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.61 0.39 2.57e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs6700896 0.898 rs1938495 chr1:66106469 A/G cg04111102 chr1:66153794 NA 0.34 8.45 0.32 1.97e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg18876405 chr7:65276391 NA 0.55 13.14 0.46 4.51e-35 Aortic root size; BRCA trans rs6598955 0.671 rs10902727 chr1:26597781 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs4595586 0.545 rs12833238 chr12:39373898 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs4925114 0.568 rs4925109 chr17:17661802 A/G cg04398451 chr17:18023971 MYO15A 0.45 9.19 0.34 5.51e-19 Body mass index; BRCA cis rs7264396 0.635 rs6060688 chr20:34516731 C/G cg04508476 chr20:34239394 CPNE1;RBM12 0.69 14.46 0.5 3.43e-41 Total cholesterol levels; BRCA cis rs67981189 0.634 rs2526875 chr14:71378360 G/C cg15816911 chr14:71606274 NA -0.37 -8.45 -0.32 2.03e-16 Schizophrenia; BRCA cis rs2070433 0.539 rs56157650 chr21:47957959 T/C cg12379764 chr21:47803548 PCNT 0.59 12.56 0.44 1.77e-32 Lymphocyte counts; BRCA cis rs72792276 1.000 rs78529289 chr5:127405378 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.61 10.37 0.38 2.21e-23 Red cell distribution width; BRCA cis rs9527 0.590 rs3861984 chr10:104916980 T/C cg04362960 chr10:104952993 NT5C2 0.45 10.43 0.38 1.29e-23 Arsenic metabolism; BRCA cis rs3820928 0.874 rs4675131 chr2:227836742 T/G cg11843606 chr2:227700838 RHBDD1 -0.39 -8.37 -0.31 3.68e-16 Pulmonary function; BRCA cis rs6138458 1.000 rs7268095 chr20:24972333 C/T cg26195577 chr20:24973756 C20orf3 1.03 28.97 0.75 1.68e-118 Blood protein levels; BRCA cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg01884057 chr2:25150051 NA 0.35 9.26 0.34 3.07e-19 Body mass index; BRCA cis rs965469 1.000 rs6051790 chr20:3342994 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -10.52 -0.38 5.66e-24 IFN-related cytopenia; BRCA cis rs483180 0.855 rs562038 chr1:120254545 G/C cg19096424 chr1:120255104 PHGDH 0.62 13.28 0.47 9.88e-36 Macular telangiectasia type 2; BRCA cis rs1949733 1.000 rs6837429 chr4:8502374 A/G cg13073564 chr4:8508604 NA -0.44 -11.99 -0.43 4.87e-30 Response to antineoplastic agents; BRCA cis rs9341808 0.718 rs1324123 chr6:80932894 G/A cg08355045 chr6:80787529 NA 0.39 9.98 0.37 6.98e-22 Sitting height ratio; BRCA cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg21699342 chr2:239360505 ASB1 0.5 11.52 0.41 5.08e-28 Multiple system atrophy; BRCA cis rs733592 0.929 rs4760678 chr12:48461581 T/C cg24011408 chr12:48396354 COL2A1 -0.46 -9.79 -0.36 3.39e-21 Plateletcrit; BRCA cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg22535103 chr8:58192502 C8orf71 -0.63 -13.59 -0.47 3.99e-37 Developmental language disorder (linguistic errors); BRCA trans rs66887589 0.837 rs6534135 chr4:120406302 A/G cg25214090 chr10:38739885 LOC399744 0.35 7.92 0.3 1.04e-14 Diastolic blood pressure; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg04025307 chr7:1156635 C7orf50 0.59 9.23 0.34 4.08e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24549020 chr5:56110836 MAP3K1 0.6 12.16 0.43 9.47e-31 Initial pursuit acceleration; BRCA cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.57 0.45 1.51e-32 Bipolar disorder; BRCA trans rs2797160 0.935 rs1739379 chr6:126012593 T/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.85 0.3 1.76e-14 Endometrial cancer; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg03354898 chr7:1950403 MAD1L1 -0.39 -8.19 -0.31 1.38e-15 Bipolar disorder and schizophrenia; BRCA cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg04688828 chr8:143858612 LYNX1 -0.38 -8.14 -0.31 2.1e-15 Urinary tract infection frequency; BRCA cis rs9393777 0.623 rs56296968 chr6:26474571 C/T cg12826209 chr6:26865740 GUSBL1 0.56 9.25 0.34 3.28e-19 Intelligence (multi-trait analysis); BRCA cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg16325326 chr1:53192061 ZYG11B -0.73 -19.03 -0.6 2.63e-64 Monocyte count; BRCA cis rs7635838 0.617 rs346076 chr3:11292682 A/G cg00170343 chr3:11313890 ATG7 -0.47 -9.82 -0.36 2.79e-21 HDL cholesterol; BRCA trans rs3812049 0.826 rs17764730 chr5:127357526 A/G cg16011800 chr17:1958478 HIC1 -0.51 -8.48 -0.32 1.5e-16 Lymphocyte counts;Red cell distribution width; BRCA cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg26647111 chr11:31128758 NA -0.44 -9.67 -0.36 9.59e-21 Red blood cell count; BRCA cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg20607287 chr7:12443886 VWDE -0.51 -8.17 -0.31 1.69e-15 Coronary artery disease; BRCA trans rs877282 0.583 rs112372193 chr10:826602 A/G cg22713356 chr15:30763199 NA 0.95 15.33 0.52 2.01e-45 Uric acid levels; BRCA cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg08048268 chr3:133502702 NA -0.33 -8.26 -0.31 8.58e-16 Iron status biomarkers; BRCA cis rs679087 1.000 rs302315 chr12:29919054 G/C cg14258853 chr12:29935411 TMTC1 -0.43 -9.05 -0.34 1.71e-18 Schizophrenia; BRCA cis rs7903847 0.642 rs10882911 chr10:99138064 A/C cg20016023 chr10:99160130 RRP12 -0.27 -8.59 -0.32 6.67e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2404602 0.647 rs8025991 chr15:77155268 C/T cg23625390 chr15:77176239 SCAPER -0.54 -13.61 -0.47 3.16e-37 Blood metabolite levels; BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg03354898 chr7:1950403 MAD1L1 -0.47 -9.26 -0.34 3.15e-19 Bipolar disorder and schizophrenia; BRCA cis rs1577917 0.958 rs7453105 chr6:86500761 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.1 -0.43 1.71e-30 Response to antipsychotic treatment; BRCA cis rs881375 0.967 rs2270231 chr9:123650982 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.66 0.32 3.82e-17 Rheumatoid arthritis; BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg12311346 chr5:56204834 C5orf35 0.77 15.15 0.51 1.52e-44 Initial pursuit acceleration; BRCA cis rs11599315 1.000 rs11599315 chr10:1343017 C/T cg09624528 chr10:1369823 ADARB2 0.44 8.63 0.32 5.05e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs939658 1.000 rs8027411 chr15:79461029 G/T cg17916960 chr15:79447300 NA 0.39 9.95 0.37 8.63e-22 Refractive error; BRCA cis rs3806843 0.808 rs6893708 chr5:140125922 T/C cg11822812 chr5:140052017 DND1 -0.32 -8.74 -0.33 2.05e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg10802521 chr3:52805072 NEK4 -0.31 -7.91 -0.3 1.14e-14 Bipolar disorder; BRCA cis rs11583043 0.874 rs41312668 chr1:101443582 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.36 7.86 0.3 1.66e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs941873 0.900 rs4979861 chr10:81131595 A/G cg09469691 chr10:81107165 PPIF 0.52 10.69 0.39 1.24e-24 Height; BRCA cis rs13191362 0.938 rs13208970 chr6:163006368 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.97 0.3 7.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.09e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs425277 0.565 rs2480711 chr1:2111376 A/G cg19257562 chr1:2043853 PRKCZ -0.33 -8.73 -0.33 2.19e-17 Height; BRCA cis rs941873 0.803 rs2105461 chr10:81101679 A/G cg09469691 chr10:81107165 PPIF -0.52 -11.05 -0.4 4.45e-26 Height; BRCA cis rs9467711 0.591 rs10484435 chr6:26031811 A/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.55 7.82 0.3 2.12e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs9942416 0.617 rs72633979 chr5:74990178 A/T cg19683494 chr5:74908142 NA 0.48 8.92 0.33 4.95e-18 Age-related disease endophenotypes; BRCA cis rs2070488 0.932 rs4678604 chr3:38444273 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.41 0.61 2.56e-66 Electrocardiographic conduction measures; BRCA trans rs3780486 0.846 rs7849148 chr9:33138352 A/T cg20290983 chr6:43655470 MRPS18A 1.11 40.57 0.85 5.58e-179 IgG glycosylation; BRCA trans rs2018683 0.523 rs886834 chr7:29021336 G/A cg19402173 chr7:128379420 CALU -0.38 -8.4 -0.32 2.9e-16 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg02951883 chr7:2050386 MAD1L1 -0.51 -11.94 -0.43 8.45e-30 Schizophrenia; BRCA cis rs801193 1.000 rs2707854 chr7:66212597 G/A cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA cis rs2153535 0.601 rs4140584 chr6:8540614 C/G cg23788917 chr6:8435910 SLC35B3 -0.48 -10.44 -0.38 1.12e-23 Motion sickness; BRCA cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg08000102 chr2:233561755 GIGYF2 0.61 13.48 0.47 1.29e-36 Coronary artery disease; BRCA cis rs6570726 0.764 rs9386125 chr6:145911677 C/T cg23711669 chr6:146136114 FBXO30 0.73 17.3 0.56 2.77e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs11711311 1.000 rs2566963 chr3:113531849 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 0.48 10.57 0.39 3.7e-24 IgG glycosylation; BRCA cis rs2985684 0.948 rs12897941 chr14:50016701 G/C cg04989706 chr14:50066350 PPIL5 -0.47 -9.12 -0.34 9.4e-19 Carotid intima media thickness; BRCA cis rs2404602 0.647 rs3812909 chr15:77176200 A/T cg23625390 chr15:77176239 SCAPER -0.55 -13.9 -0.48 1.44e-38 Blood metabolite levels; BRCA cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg05347473 chr6:146136440 FBXO30 0.43 8.79 0.33 1.43e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.41 -0.38 1.49e-23 Reticulocyte count; BRCA cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg24812749 chr6:127587940 RNF146 0.87 20.04 0.62 1.06e-69 Breast cancer; BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg14004847 chr7:1930337 MAD1L1 -0.47 -9.05 -0.34 1.76e-18 Bipolar disorder and schizophrenia; BRCA cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg12373951 chr3:133503437 NA 0.53 12.57 0.45 1.51e-32 Iron status biomarkers; BRCA cis rs651907 0.557 rs7651721 chr3:101393583 C/A cg12386194 chr3:101231763 SENP7 0.45 9.53 0.35 3.33e-20 Colorectal cancer; BRCA cis rs870825 0.929 rs10003354 chr4:185589782 G/A cg04058563 chr4:185651563 MLF1IP 0.68 11.54 0.42 4.01e-28 Blood protein levels; BRCA trans rs8073060 0.544 rs225287 chr17:33929487 G/T cg19694781 chr19:47549865 TMEM160 -1.01 -20.68 -0.63 4.01e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7809950 1.000 rs2712215 chr7:107188207 A/G cg23024343 chr7:107201750 COG5 -0.4 -9.3 -0.35 2.14e-19 Coronary artery disease; BRCA cis rs1707322 0.721 rs6699418 chr1:46100181 G/A cg24296786 chr1:45957014 TESK2 -0.39 -8.13 -0.31 2.17e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17376456 0.597 rs10064158 chr5:93095186 C/T cg25358565 chr5:93447407 FAM172A 0.69 11.87 0.42 1.73e-29 Diabetic retinopathy; BRCA trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs72627509 0.680 rs66790703 chr4:57773908 G/A cg26694713 chr4:57773883 REST 0.5 10.03 0.37 4.39e-22 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs138880 0.580 rs28562884 chr22:50312869 T/C cg02269571 chr22:50332266 NA -0.55 -7.84 -0.3 1.94e-14 Schizophrenia; BRCA cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg26373071 chr5:1325741 CLPTM1L 0.48 11.46 0.41 8.71e-28 Lung cancer; BRCA cis rs72848980 0.512 rs12359556 chr10:105390677 C/T cg00126946 chr10:105363258 SH3PXD2A 0.43 8.37 0.31 3.62e-16 White matter hyperintensity burden; BRCA cis rs17270561 0.609 rs3922699 chr6:25734969 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs16854884 0.683 rs2053211 chr3:143774592 C/T cg06585982 chr3:143692056 C3orf58 -0.47 -9.1 -0.34 1.17e-18 Economic and political preferences (feminism/equality); BRCA cis rs57590327 0.503 rs7426937 chr3:81881360 T/C cg07356753 chr3:81810745 GBE1 -0.41 -9.6 -0.35 1.85e-20 Extraversion; BRCA cis rs250677 0.522 rs10040798 chr5:148367324 A/G cg18129178 chr5:148520854 ABLIM3 0.53 10.25 0.38 6.53e-23 Breast cancer; BRCA cis rs688020 1.000 rs688020 chr7:4228553 C/T cg02004499 chr7:4244250 SDK1 0.43 9.16 0.34 6.81e-19 Liver fibrosis in pediatric non-alcoholic fatty acid liver disease; BRCA cis rs4663866 1.000 rs4663865 chr2:239145960 C/T cg16914508 chr2:239161102 PER2 -0.61 -8.88 -0.33 6.53e-18 Irritable bowel syndrome; BRCA trans rs6089829 0.962 rs6011544 chr20:61658782 T/C cg23505145 chr19:12996616 KLF1 0.56 12.65 0.45 6.93e-33 Prostate cancer (SNP x SNP interaction); BRCA trans rs11098499 0.863 rs11098531 chr4:120465001 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -15.24 -0.52 5.84e-45 Systemic lupus erythematosus; BRCA cis rs752010 0.806 rs4457567 chr1:42091407 C/T cg06885757 chr1:42089581 HIVEP3 0.28 10.28 0.38 4.88e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg00105475 chr2:10696890 NA 0.43 10.19 0.37 1.04e-22 Prostate cancer; BRCA cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.4 0.32 2.9e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7267979 1.000 rs11087521 chr20:25440648 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.53 0.32 1.05e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9814567 1.000 rs9876658 chr3:134179453 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.56 17.77 0.58 1.04e-57 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7131987 0.903 rs67150462 chr12:29393325 T/C cg09582351 chr12:29534625 ERGIC2 -0.41 -9.68 -0.36 8.65e-21 QT interval; BRCA cis rs6542838 0.704 rs13011428 chr2:99528305 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -9.51 -0.35 3.69e-20 Fear of minor pain; BRCA cis rs7572733 0.515 rs13408411 chr2:198825462 G/A cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.47e-21 Dermatomyositis; BRCA cis rs1801251 0.964 rs10933411 chr2:233706847 A/G cg08000102 chr2:233561755 GIGYF2 -0.63 -13.61 -0.47 3.18e-37 Coronary artery disease; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg13047869 chr3:10149882 C3orf24 0.56 10.35 0.38 2.51e-23 Alzheimer's disease; BRCA cis rs514406 0.929 rs554301 chr1:53321948 A/T cg24675658 chr1:53192096 ZYG11B 0.52 11.58 0.42 2.65e-28 Monocyte count; BRCA cis rs9837602 1.000 rs71313585 chr3:99770696 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.31e-26 Breast cancer; BRCA cis rs8072100 0.967 rs4794058 chr17:45597098 C/T cg19784903 chr17:45786737 TBKBP1 0.33 7.85 0.3 1.75e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7408868 0.908 rs62113793 chr19:15277336 G/A cg14696996 chr19:15285081 NOTCH3 1.02 14.48 0.5 2.56e-41 Pulse pressure; BRCA cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg27286337 chr10:134555280 INPP5A 0.8 12.94 0.46 3.49e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6088580 0.542 rs6059882 chr20:33090167 T/C cg24642439 chr20:33292090 TP53INP2 0.53 11.65 0.42 1.42e-28 Glomerular filtration rate (creatinine); BRCA cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.86e-54 Bladder cancer; BRCA cis rs8177253 1.000 rs3811647 chr3:133484029 G/A cg11941060 chr3:133502564 NA -0.51 -12.17 -0.43 8.96e-31 Iron status biomarkers; BRCA cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg07493874 chr5:1342172 CLPTM1L -0.47 -13.04 -0.46 1.22e-34 Lung cancer; BRCA cis rs1185460 1.000 rs7127212 chr11:118953202 A/G cg23280166 chr11:118938394 VPS11 -0.36 -8.57 -0.32 7.69e-17 Coronary artery disease; BRCA cis rs735396 0.965 rs2257962 chr12:121445808 T/C cg02403541 chr12:121454288 C12orf43 0.53 10.08 0.37 2.74e-22 N-glycan levels; BRCA cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.5 0.38 6.5e-24 Tonsillectomy; BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 17.01 0.56 8.75e-54 Alzheimer's disease; BRCA cis rs2439831 0.850 rs8032649 chr15:44134922 C/T cg27015174 chr15:43622946 ADAL;LCMT2 -0.5 -9.47 -0.35 5.48e-20 Lung cancer in ever smokers; BRCA cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg24110177 chr3:50126178 RBM5 -0.41 -11.17 -0.4 1.39e-26 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.593 rs12216730 chr8:58003894 C/T cg21724239 chr8:58056113 NA 0.51 8.76 0.33 1.71e-17 Developmental language disorder (linguistic errors); BRCA cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06022373 chr22:39101656 GTPBP1 -0.74 -16.62 -0.55 8.19e-52 Menopause (age at onset); BRCA cis rs881375 0.678 rs10118357 chr9:123680068 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.55 11.68 0.42 1.02e-28 Rheumatoid arthritis; BRCA cis rs2479724 0.846 rs1536702 chr6:41869950 T/A cg17623882 chr6:41773611 USP49 -0.35 -9.47 -0.35 5.16e-20 Menarche (age at onset); BRCA cis rs7666738 0.578 rs1989109 chr4:98881246 T/A cg05340658 chr4:99064831 C4orf37 0.63 15.04 0.51 5.65e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg08805041 chr16:621841 PIGQ -0.31 -8.52 -0.32 1.14e-16 Height; BRCA cis rs11105298 0.891 rs10858900 chr12:89925081 C/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.32 -0.35 1.92e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs4268898 0.697 rs6714652 chr2:24383059 C/T cg26838691 chr2:24397539 C2orf84 0.4 8.08 0.3 3.3e-15 Asthma; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 14.12 0.49 1.31e-39 Alzheimer's disease; BRCA cis rs3806843 1.000 rs3806845 chr5:140180737 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.86 -0.36 1.91e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs9325144 0.625 rs12227353 chr12:38734542 C/T cg23762105 chr12:34175262 ALG10 0.37 8.53 0.32 1.1e-16 Morning vs. evening chronotype; BRCA cis rs9790314 0.905 rs4856739 chr3:160986710 A/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.36 -0.49 9.48e-41 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs9883753 chr3:134247231 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.52 -0.61 6.85e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.84 -17.25 -0.56 4.93e-55 Alzheimer's disease; BRCA cis rs17270561 0.609 rs2275905 chr6:25768106 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg16506815 chr2:162101123 NA -0.45 -8.65 -0.32 4.23e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); BRCA cis rs780096 0.546 rs715326 chr2:27725761 A/G cg17158414 chr2:27665306 KRTCAP3 0.31 8.11 0.31 2.6e-15 Total body bone mineral density; BRCA cis rs13046373 0.535 rs2832964 chr21:32014012 A/C cg06468780 chr21:31798236 KRTAP13-3 0.34 8.46 0.32 1.85e-16 HDL cholesterol; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg05863683 chr7:1912471 MAD1L1 -0.35 -8.23 -0.31 1.06e-15 Bipolar disorder and schizophrenia; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg24846343 chr22:24311635 DDTL 0.5 12.17 0.43 8.22e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs78487399 0.908 rs6725688 chr2:43846553 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.53 -8.03 -0.3 4.55e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs7666738 0.830 rs13137859 chr4:99050319 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9467773 1.000 rs9461259 chr6:26504835 C/A cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.23e-60 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.586 rs35713426 chr3:161131271 A/G cg03342759 chr3:160939853 NMD3 -0.65 -15.12 -0.51 2.13e-44 Morning vs. evening chronotype; BRCA cis rs796364 1.000 rs281788 chr2:200783705 A/T cg23649088 chr2:200775458 C2orf69 0.6 8.87 0.33 7.04e-18 Schizophrenia; BRCA cis rs1008375 1.000 rs11727312 chr4:17669185 C/T cg04450456 chr4:17643702 FAM184B 0.37 10.73 0.39 8.05e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7481584 0.646 rs434114 chr11:3050210 A/G cg08508325 chr11:3079039 CARS 0.28 8.43 0.32 2.22e-16 Calcium levels; BRCA cis rs425277 0.606 rs2460001 chr1:2111030 T/C cg19257562 chr1:2043853 PRKCZ -0.33 -8.86 -0.33 7.64e-18 Height; BRCA cis rs1420338 0.933 rs1362460 chr7:34147964 C/T cg01275685 chr7:34179230 BMPER -0.52 -11.68 -0.42 1.03e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7249142 0.562 rs10854009 chr19:19284705 A/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.41 -8.79 -0.33 1.43e-17 IgG glycosylation; BRCA trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg21775007 chr8:11205619 TDH -0.4 -8.51 -0.32 1.23e-16 Neuroticism; BRCA cis rs7188861 0.861 rs7197188 chr16:11443424 C/A cg01510278 chr16:11456238 NA -0.38 -8.13 -0.31 2.23e-15 HDL cholesterol; BRCA cis rs3892630 0.824 rs35654350 chr19:33223766 T/C cg22980127 chr19:33182716 NUDT19 0.9 17.65 0.57 4.12e-57 Red blood cell traits; BRCA trans rs79976124 0.837 rs11751994 chr6:66644028 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.76 0.39 6.29e-25 Type 2 diabetes; BRCA cis rs10752881 1.000 rs6424879 chr1:182986592 T/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.17e-52 Colorectal cancer; BRCA cis rs12618769 0.597 rs11884553 chr2:99131206 T/C cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.5e-36 High light scatter reticulocyte count; BRCA cis rs6598955 0.671 rs17163868 chr1:26648381 A/G cg00852783 chr1:26633632 UBXN11 0.43 8.06 0.3 3.69e-15 Obesity-related traits; BRCA cis rs1801251 1.000 rs2592105 chr2:233645968 C/G cg25237894 chr2:233734115 C2orf82 0.39 10.98 0.4 8.04e-26 Coronary artery disease; BRCA cis rs10927875 0.691 rs1048261 chr1:16340951 A/T cg22431228 chr1:16359049 CLCNKA -0.45 -9.27 -0.34 2.91e-19 Dilated cardiomyopathy; BRCA cis rs6460942 0.915 rs75158182 chr7:12456059 C/T cg06484146 chr7:12443880 VWDE -0.75 -10.63 -0.39 2.15e-24 Coronary artery disease; BRCA cis rs35306767 0.855 rs34251037 chr10:867884 C/T cg26597838 chr10:835615 NA 1.3 21.81 0.65 2.87e-79 Eosinophil percentage of granulocytes; BRCA cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.21 0.41 9.55e-27 Bipolar disorder; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg13047869 chr3:10149882 C3orf24 0.52 11.01 0.4 6.24e-26 Alzheimer's disease; BRCA cis rs7116495 0.609 rs10501408 chr11:71680590 C/T cg10381502 chr11:71823885 C11orf51 -0.9 -9.4 -0.35 9.44e-20 Severe influenza A (H1N1) infection; BRCA cis rs782590 0.902 rs3762513 chr2:55762957 C/T cg18811423 chr2:55921094 PNPT1 0.71 22.4 0.66 1.91e-82 Metabolic syndrome; BRCA cis rs4988958 0.584 rs7589142 chr2:103024660 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.25e-16 Asthma (childhood onset); BRCA cis rs67478160 0.619 rs1187416 chr14:104311465 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.25 0.59 3.25e-60 Schizophrenia; BRCA cis rs752010 0.806 rs4641303 chr1:42091310 A/G cg06885757 chr1:42089581 HIVEP3 0.28 10.28 0.38 4.88e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs910873 0.505 rs6059969 chr20:33245284 T/C cg16810054 chr20:33298113 TP53INP2 -0.48 -10.4 -0.38 1.62e-23 Melanoma; BRCA cis rs2882667 0.690 rs11954103 chr5:138269148 G/A cg04439458 chr5:138467593 SIL1 -0.37 -8.66 -0.32 3.75e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg14004847 chr7:1930337 MAD1L1 0.43 8.86 0.33 8.16e-18 Bipolar disorder and schizophrenia; BRCA cis rs7777754 0.734 rs4947709 chr7:50672907 A/G cg18232548 chr7:50535776 DDC -0.34 -8.09 -0.3 3.04e-15 Response to zileuton treatment in asthma (FEV1 change interaction); BRCA cis rs9486719 1.000 rs2472886 chr6:96864876 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA trans rs6582630 0.502 rs7312212 chr12:38274760 T/G cg06521331 chr12:34319734 NA -0.51 -9.62 -0.36 1.47e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs2286885 0.965 rs10987301 chr9:129250688 T/C cg15282417 chr9:129245246 FAM125B -0.31 -7.95 -0.3 8.77e-15 Intraocular pressure; BRCA cis rs11622475 0.677 rs7145372 chr14:104359121 A/G cg12183467 chr14:104352244 NA 0.45 9.8 0.36 3.1e-21 Bipolar disorder; BRCA cis rs477692 0.685 rs3852507 chr10:131399616 G/T cg05714579 chr10:131428358 MGMT -0.54 -12.83 -0.45 1.11e-33 Response to temozolomide; BRCA cis rs7394190 0.688 rs76033784 chr10:75535970 A/G cg07699608 chr10:75541558 CHCHD1 0.65 9.64 0.36 1.26e-20 Incident atrial fibrillation; BRCA cis rs17095355 1.000 rs731793 chr10:111716667 C/G cg00817464 chr10:111662876 XPNPEP1 0.38 9.95 0.37 9.12e-22 Biliary atresia; BRCA cis rs7246657 0.943 rs1015848 chr19:37945274 A/C cg18154014 chr19:37997991 ZNF793 0.62 11.64 0.42 1.49e-28 Coronary artery calcification; BRCA trans rs11098499 0.863 rs12502389 chr4:120454191 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs2762353 0.595 rs13194155 chr6:25755508 C/T cg12310025 chr6:25882481 NA 0.72 17.85 0.58 4.14e-58 Blood metabolite levels; BRCA cis rs2153535 0.580 rs6927589 chr6:8456632 A/G cg21535247 chr6:8435926 SLC35B3 -0.39 -8.85 -0.33 8.3e-18 Motion sickness; BRCA cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg20701182 chr2:24300061 SF3B14 0.56 8.65 0.32 4.24e-17 Lymphocyte counts; BRCA cis rs6701037 0.512 rs4650716 chr1:175128711 C/A cg14847009 chr1:175162515 KIAA0040 0.26 9.98 0.37 6.73e-22 Alcohol dependence; BRCA cis rs9733 0.650 rs11204680 chr1:150587140 T/G cg18016565 chr1:150552671 MCL1 -0.45 -10.08 -0.37 2.91e-22 Tonsillectomy; BRCA cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg05340658 chr4:99064831 C4orf37 0.62 14.71 0.5 2.04e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.45 -10.68 -0.39 1.34e-24 Depressive symptoms (multi-trait analysis); BRCA cis rs12995491 0.933 rs34366691 chr2:88537451 G/A cg04511125 chr2:88470314 THNSL2 -0.45 -9.09 -0.34 1.26e-18 Response to metformin (IC50); BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg08888203 chr3:10149979 C3orf24 0.68 14.5 0.5 2.22e-41 Alzheimer's disease; BRCA cis rs4566357 0.557 rs6707158 chr2:227911269 A/G cg05526886 chr2:227700861 RHBDD1 -0.39 -8.12 -0.31 2.34e-15 Coronary artery disease; BRCA cis rs17376456 1.000 rs9968691 chr5:93509756 C/G cg25358565 chr5:93447407 FAM172A 1.18 18.56 0.59 7.72e-62 Diabetic retinopathy; BRCA cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.66 -0.42 1.31e-28 Bipolar disorder; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg27170947 chr2:26402098 FAM59B -0.85 -15.96 -0.53 1.7e-48 Gut microbiome composition (summer); BRCA cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg16179182 chr5:140090404 VTRNA1-1 0.46 10.84 0.39 2.92e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs12048904 0.619 rs3737581 chr1:101341083 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.77 21.03 0.64 5.28e-75 Multiple sclerosis; BRCA cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg11833968 chr6:79620685 NA -0.4 -8.59 -0.32 6.68e-17 Intelligence (multi-trait analysis); BRCA cis rs72634258 0.554 rs35307738 chr1:7919839 C/G cg26816564 chr1:7831052 VAMP3 0.54 10.53 0.38 5.3e-24 Inflammatory bowel disease; BRCA cis rs12950390 0.853 rs67441169 chr17:45854462 T/G cg24803719 chr17:45855879 NA -0.31 -8.1 -0.31 2.77e-15 IgG glycosylation; BRCA cis rs4924935 0.770 rs4924946 chr17:18846525 A/T cg26306683 chr17:18585705 ZNF286B -0.31 -8.39 -0.32 3.08e-16 Pancreatic cancer; BRCA cis rs875971 0.767 rs12668005 chr7:65909021 T/C cg11764359 chr7:65958608 NA 0.74 16.3 0.54 3.24e-50 Aortic root size; BRCA cis rs4631830 0.832 rs2611513 chr10:51515457 A/G cg20129853 chr10:51489980 NA 0.28 7.87 0.3 1.53e-14 Prostate-specific antigen levels; BRCA cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.77e-24 Motion sickness; BRCA cis rs2882667 0.898 rs6863347 chr5:138361135 C/T cg04439458 chr5:138467593 SIL1 -0.32 -8.71 -0.33 2.51e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1784581 0.674 rs1784592 chr6:162387365 T/A cg17173639 chr6:162384350 PARK2 -0.38 -9.08 -0.34 1.33e-18 Itch intensity from mosquito bite; BRCA cis rs7246657 0.722 rs2972430 chr19:38182111 C/T cg14683738 chr19:37701593 ZNF585B -0.47 -8.04 -0.3 4.29e-15 Coronary artery calcification; BRCA cis rs72772090 0.539 rs67140788 chr5:96116286 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.19 -0.43 7.23e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1451375 0.657 rs12672526 chr7:50657695 C/T cg18232548 chr7:50535776 DDC 0.41 9.36 0.35 1.38e-19 Malaria; BRCA trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.93 -0.3 9.66e-15 Corneal astigmatism; BRCA cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg21856205 chr7:94953877 PON1 -0.37 -7.93 -0.3 9.6e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs589448 0.902 rs315134 chr12:69762713 G/A cg22834771 chr12:69754056 YEATS4 -0.41 -10.28 -0.38 4.7e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs2243480 1.000 rs55895244 chr7:65387678 C/G cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg24562669 chr7:97807699 LMTK2 0.46 12.19 0.43 7.37e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg01579765 chr21:45077557 HSF2BP -0.37 -10.06 -0.37 3.46e-22 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.75e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.669 rs7630768 chr3:160864879 T/A cg03342759 chr3:160939853 NMD3 -0.59 -13.03 -0.46 1.37e-34 Morning vs. evening chronotype; BRCA cis rs4808199 0.948 rs2074301 chr19:19381715 G/A cg03709012 chr19:19516395 GATAD2A 0.96 17.06 0.56 4.73e-54 Nonalcoholic fatty liver disease; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs7552404 0.731 rs1770887 chr1:76401812 A/G cg22875332 chr1:76189707 ACADM -0.46 -8.86 -0.33 8.17e-18 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg02079420 chr8:82753780 SNX16 0.31 7.94 0.3 9.08e-15 Diastolic blood pressure; BRCA cis rs921968 0.565 rs6436069 chr2:219597185 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.07 -0.4 3.48e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs7618915 0.547 rs13069481 chr3:52666866 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.85 0.36 2.07e-21 Bipolar disorder; BRCA cis rs2836974 0.932 rs11910151 chr21:40560262 T/C cg11890956 chr21:40555474 PSMG1 1.09 33.17 0.8 4.71e-141 Cognitive function; BRCA trans rs11039798 0.511 rs717896 chr11:48375335 G/T cg03929089 chr4:120376271 NA -0.53 -8.82 -0.33 1.09e-17 Axial length; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg05552183 chr6:42928497 GNMT 0.67 14.93 0.51 1.77e-43 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -11.4 -0.41 1.57e-27 Electroencephalogram traits; BRCA cis rs7772486 0.534 rs34541797 chr6:146205304 A/G cg13319975 chr6:146136371 FBXO30 -0.61 -13.94 -0.48 9.12e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg08392591 chr16:89556376 ANKRD11 0.51 12.45 0.44 5.39e-32 Multiple myeloma (IgH translocation); BRCA cis rs1691799 0.899 rs1168322 chr12:66743769 C/T cg16791601 chr12:66731901 HELB -0.69 -19.67 -0.61 1.03e-67 White blood cell count (basophil); BRCA cis rs117623576 0.941 rs211422 chr10:32398589 A/G cg03047570 chr10:32398778 NA 0.62 9.32 0.35 1.87e-19 Anti-saccade response; BRCA cis rs7095944 0.614 rs10901816 chr10:126440395 G/A cg08799069 chr10:126477246 METTL10 -0.4 -9.49 -0.35 4.41e-20 Asthma; BRCA cis rs10771431 0.597 rs10843144 chr12:9357577 C/T cg08997352 chr12:9597637 DDX12 -0.54 -10.43 -0.38 1.25e-23 Breast size; BRCA cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg17724175 chr1:150552817 MCL1 0.25 8.04 0.3 4.52e-15 Melanoma; BRCA cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg12573674 chr2:1569213 NA -0.51 -9.66 -0.36 1.09e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11644478 chr21:40555479 PSMG1 -0.51 -10.76 -0.39 6.25e-25 Menarche (age at onset); BRCA trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21582582 chr3:182698605 DCUN1D1 -0.38 -10.09 -0.37 2.52e-22 Intelligence (multi-trait analysis); BRCA cis rs977987 0.806 rs7185640 chr16:75394399 A/G cg03315344 chr16:75512273 CHST6 0.52 12.41 0.44 8.12e-32 Dupuytren's disease; BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26314531 chr2:26401878 FAM59B -0.66 -11.2 -0.4 1.08e-26 Gut microbiome composition (summer); BRCA cis rs6121246 0.909 rs6060821 chr20:30294034 C/T cg21427119 chr20:30132790 HM13 -0.42 -8.76 -0.33 1.72e-17 Mean corpuscular hemoglobin; BRCA cis rs17401966 0.931 rs1555849 chr1:10400602 G/T cg03954927 chr1:10346856 KIF1B -0.48 -15.06 -0.51 4.47e-44 Hepatocellular carcinoma; BRCA cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg12826209 chr6:26865740 GUSBL1 0.6 10.56 0.39 4e-24 Intelligence (multi-trait analysis); BRCA cis rs9660992 0.710 rs1668869 chr1:205239779 G/C cg00857998 chr1:205179979 DSTYK 0.43 8.2 0.31 1.36e-15 Mean corpuscular volume;Mean platelet volume; BRCA trans rs637571 0.522 rs12797319 chr11:65735672 G/A cg17712092 chr4:129076599 LARP1B 0.62 14.8 0.51 7.63e-43 Eosinophil percentage of white cells; BRCA cis rs10044254 0.614 rs4273604 chr5:15732604 A/C cg07238450 chr5:15720153 FBXL7 -0.38 -7.91 -0.3 1.12e-14 Asthma (corticosteroid response); BRCA cis rs7605378 0.752 rs769960 chr2:200710706 G/T cg23649088 chr2:200775458 C2orf69 -0.63 -12.39 -0.44 9.68e-32 Osteoporosis; BRCA cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg23029597 chr12:123009494 RSRC2 -0.6 -11.78 -0.42 3.83e-29 Body mass index; BRCA cis rs919433 0.963 rs1366837 chr2:198160501 T/C cg10820045 chr2:198174542 NA -0.42 -9.61 -0.36 1.65e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs55665837 1.000 rs12804549 chr11:14437758 A/T cg19336497 chr11:14380999 RRAS2 -0.37 -9.66 -0.36 1.03e-20 Vitamin D levels; BRCA cis rs9614461 0.609 rs9614653 chr22:45767391 A/G cg23503501 chr22:45809793 SMC1B;RIBC2 -0.55 -7.99 -0.3 6.09e-15 Tonsillectomy; BRCA cis rs12142240 0.738 rs10489769 chr1:46806703 A/G cg14993813 chr1:46806288 NSUN4 -0.47 -9.04 -0.34 1.91e-18 Menopause (age at onset); BRCA cis rs1020064 0.636 rs2679876 chr2:105938107 T/C cg02079111 chr2:105885981 TGFBRAP1 0.41 7.93 0.3 1.02e-14 AIDS; BRCA trans rs7824557 0.724 rs2572398 chr8:11178093 A/C cg06636001 chr8:8085503 FLJ10661 0.59 12.67 0.45 5.51e-33 Retinal vascular caliber; BRCA cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 16.64 0.55 6.06e-52 Colorectal cancer; BRCA cis rs6545883 0.929 rs2463100 chr2:61659199 C/G cg15711740 chr2:61764176 XPO1 -0.52 -11.64 -0.42 1.49e-28 Tuberculosis; BRCA cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg18446336 chr7:2847575 GNA12 -0.35 -8.22 -0.31 1.15e-15 Height; BRCA cis rs8014204 0.762 rs2359237 chr14:75245002 G/A cg06637938 chr14:75390232 RPS6KL1 0.43 8.83 0.33 1.02e-17 Caffeine consumption; BRCA trans rs7395662 0.591 rs4882138 chr11:48619321 A/G cg03929089 chr4:120376271 NA -0.47 -9.04 -0.34 1.9e-18 HDL cholesterol; BRCA cis rs77106637 1.000 rs11600585 chr11:72727840 A/G cg03713592 chr11:72463424 ARAP1 0.78 11.7 0.42 8.97e-29 Type 2 diabetes; BRCA cis rs4727027 0.933 rs12154382 chr7:148862284 C/T cg23583168 chr7:148888333 NA -0.86 -20.07 -0.62 7.29e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg05279229 chr7:1896384 MAD1L1 -0.4 -8.02 -0.3 5.03e-15 Schizophrenia; BRCA trans rs6598955 0.671 rs17163749 chr1:26568165 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.7 -0.53 3.33e-47 Obesity-related traits; BRCA cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg18876405 chr7:65276391 NA 0.54 12.94 0.46 3.55e-34 Aortic root size; BRCA cis rs1865760 0.515 rs2003208 chr6:25940719 G/C cg03264133 chr6:25882463 NA -0.36 -7.97 -0.3 7.37e-15 Height; BRCA trans rs6479891 1.000 rs9414799 chr10:65129602 T/C cg14819942 chr15:35414228 NA 0.35 8.49 0.32 1.4e-16 Arthritis (juvenile idiopathic); BRCA cis rs6121246 0.909 rs6119729 chr20:30413163 A/G cg13852791 chr20:30311386 BCL2L1 -0.83 -16.31 -0.54 2.9e-50 Mean corpuscular hemoglobin; BRCA cis rs7178424 0.935 rs1344601 chr15:62259066 A/T cg00456672 chr15:62358751 C2CD4A 0.38 8.54 0.32 9.52e-17 Height; BRCA cis rs4689592 0.622 rs2276968 chr4:7070118 T/G cg19539972 chr4:7069911 GRPEL1 0.7 15.77 0.53 1.45e-47 Monocyte percentage of white cells; BRCA cis rs4642101 0.824 rs3889514 chr3:12844072 T/C cg24848339 chr3:12840334 CAND2 0.41 10.53 0.38 4.9299999999999996e-24 QRS complex (12-leadsum); BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00908189 chr16:619842 PIGQ 0.71 18.56 0.59 8.33e-62 Height; BRCA cis rs3772130 0.583 rs11710169 chr3:121426655 A/G cg20356878 chr3:121714668 ILDR1 0.37 8.27 0.31 7.94e-16 Cognitive performance; BRCA cis rs679087 0.932 rs10843506 chr12:29930883 G/A cg14258853 chr12:29935411 TMTC1 0.36 8.26 0.31 8.17e-16 Schizophrenia; BRCA cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg15017067 chr4:17643749 FAM184B 0.34 10.74 0.39 7.64e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7945718 0.967 rs4757945 chr11:12808718 A/G cg25843174 chr11:12811716 TEAD1 -0.22 -8.36 -0.31 3.78e-16 Educational attainment (years of education); BRCA cis rs3008870 0.651 rs2815376 chr1:67508531 G/A cg02640540 chr1:67518911 SLC35D1 0.38 8.19 0.31 1.47e-15 Lymphocyte percentage of white cells; BRCA cis rs17376456 0.877 rs56373208 chr5:93491276 C/A cg25358565 chr5:93447407 FAM172A 1.25 19.02 0.6 2.98e-64 Diabetic retinopathy; BRCA cis rs2842992 0.830 rs2495279 chr6:160138796 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.64 0.42 1.61e-28 Age-related macular degeneration (geographic atrophy); BRCA cis rs10463316 0.862 rs11740475 chr5:150777997 A/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.43 -0.32 2.33e-16 Metabolite levels (Pyroglutamine); BRCA cis rs12612619 0.704 rs6742004 chr2:27309659 A/C cg00617064 chr2:27272375 NA -0.34 -8.89 -0.33 6.31e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7829975 0.533 rs1039917 chr8:8718850 C/T cg15556689 chr8:8085844 FLJ10661 0.43 11.1 0.4 2.54e-26 Mood instability; BRCA cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -8.55 -0.32 8.95e-17 Chronic sinus infection; BRCA cis rs911555 0.574 rs34251103 chr14:103860063 A/G cg12935359 chr14:103987150 CKB 0.61 14.18 0.49 6.76e-40 Intelligence (multi-trait analysis); BRCA cis rs921968 0.565 rs3821035 chr2:219620223 T/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 3.87e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg16145915 chr7:1198662 ZFAND2A -0.6 -14.61 -0.5 6.47e-42 Longevity;Endometriosis; BRCA cis rs74417235 0.684 rs13179754 chr5:154059845 C/T cg08754654 chr5:154026448 NA 0.42 10.06 0.37 3.5e-22 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs1401999 0.714 rs1000002 chr3:183635768 A/G cg01324343 chr3:183735012 ABCC5 -0.66 -15.37 -0.52 1.31e-45 Anterior chamber depth; BRCA cis rs1707322 0.964 rs10890358 chr1:46319025 T/A cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.26e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg14993813 chr1:46806288 NSUN4 -0.46 -8.66 -0.32 3.91e-17 Menopause (age at onset); BRCA cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.34 11.67 0.42 1.12e-28 Systemic lupus erythematosus; BRCA cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg01114163 chr5:1856713 NA -0.35 -7.88 -0.3 1.37e-14 Cardiovascular disease risk factors; BRCA cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 10.78 0.39 5.08e-25 Bipolar disorder; BRCA cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg10523679 chr1:76189770 ACADM -0.71 -12.17 -0.43 8.91e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6456156 0.586 rs13208636 chr6:167461965 T/G cg07741184 chr6:167504864 NA 0.33 9.8 0.36 3.32e-21 Primary biliary cholangitis; BRCA cis rs6782228 0.675 rs2253151 chr3:128330137 T/C cg16766828 chr3:128327626 NA -0.41 -9.09 -0.34 1.22e-18 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs6723226 0.699 rs376914 chr2:32508393 G/C cg02381751 chr2:32503542 YIPF4 0.67 14.26 0.49 2.92e-40 Intelligence (multi-trait analysis); BRCA cis rs7617773 0.815 rs7624450 chr3:48350375 A/G cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs9291683 0.588 rs3796829 chr4:10019138 C/G cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.6e-52 Bone mineral density; BRCA cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg06238570 chr21:40685208 BRWD1 -0.4 -8.17 -0.31 1.62e-15 Cognitive function; BRCA cis rs4268898 0.679 rs2543666 chr2:24446042 C/T cg06627628 chr2:24431161 ITSN2 0.69 13.54 0.47 6.44e-37 Asthma; BRCA cis rs7731783 1 rs7731783 chr5:177060312 T/C cg26673648 chr5:177209285 NA 0.39 8.89 0.33 6.24e-18 Methadone dose in opioid dependence; BRCA cis rs1499972 0.941 rs62264763 chr3:117637305 G/A cg07612923 chr3:117604196 NA 0.6 8.16 0.31 1.75e-15 Schizophrenia; BRCA trans rs11098499 0.754 rs10213554 chr4:120260785 A/G cg25214090 chr10:38739885 LOC399744 -0.46 -10.43 -0.38 1.22e-23 Corneal astigmatism; BRCA cis rs559928 0.606 rs12419038 chr11:63912736 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.68 9.42 0.35 7.87e-20 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg02951883 chr7:2050386 MAD1L1 -0.61 -15.49 -0.52 3.5e-46 Bipolar disorder and schizophrenia; BRCA cis rs914187 0.548 rs2837992 chr21:42620520 A/G cg21268422 chr21:42620091 BACE2 0.47 9.42 0.35 7.95e-20 Body mass index; BRCA cis rs2933343 0.533 rs13086121 chr3:128704290 A/T cg11901034 chr3:128598214 ACAD9 -0.34 -7.92 -0.3 1.08e-14 IgG glycosylation; BRCA cis rs651907 0.640 rs771574 chr3:101620682 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.37 7.82 0.3 2.15e-14 Colorectal cancer; BRCA cis rs1538970 0.961 rs7543428 chr1:45839643 A/G cg05343316 chr1:45956843 TESK2 0.55 11.24 0.41 7.05e-27 Platelet count; BRCA cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg09359103 chr1:154839909 KCNN3 -0.58 -15.61 -0.53 8.9e-47 Prostate cancer; BRCA cis rs6831352 0.918 rs13113166 chr4:100050528 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7520050 0.966 rs10890354 chr1:46305347 G/A cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.4e-21 Red blood cell count;Reticulocyte count; BRCA cis rs734999 0.967 rs10797433 chr1:2502010 T/C cg20673091 chr1:2541236 MMEL1 0.32 8.31 0.31 5.6e-16 Ulcerative colitis; BRCA cis rs2797160 1.000 rs1612249 chr6:126014916 C/A cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.2e-20 Endometrial cancer; BRCA cis rs2153535 0.580 rs1577467 chr6:8444241 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.53e-23 Motion sickness; BRCA cis rs35146811 0.844 rs12705070 chr7:99656927 A/G cg13334819 chr7:99746414 C7orf59 -0.39 -9.49 -0.35 4.67e-20 Coronary artery disease; BRCA cis rs6831352 0.918 rs13127582 chr4:100058194 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.76 -0.42 4.98e-29 Alcohol dependence; BRCA cis rs7811528 0.520 rs2286690 chr7:2695617 A/G cg11411865 chr7:2701802 TTYH3 -0.49 -8.97 -0.33 3.35e-18 Schizophrenia; BRCA cis rs7208859 0.673 rs61348930 chr17:29221763 C/T cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs6740322 0.895 rs9309097 chr2:43554397 T/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.28 -0.44 2.87e-31 Coronary artery disease; BRCA cis rs35306767 0.903 rs7074642 chr10:878359 A/G cg26597838 chr10:835615 NA 1.01 17.96 0.58 1.05e-58 Eosinophil percentage of granulocytes; BRCA cis rs9790314 0.846 rs9834659 chr3:160980947 A/C cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.09e-59 Morning vs. evening chronotype; BRCA cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg10523679 chr1:76189770 ACADM -0.46 -8.92 -0.33 5.05e-18 Daytime sleep phenotypes; BRCA cis rs36051895 0.664 rs3780369 chr9:5095095 A/C cg02405213 chr9:5042618 JAK2 -0.51 -9.16 -0.34 7.19e-19 Pediatric autoimmune diseases; BRCA cis rs2625529 0.701 rs12911154 chr15:72212653 G/A cg16672083 chr15:72433130 SENP8 -0.84 -17.27 -0.56 4.16e-55 Red blood cell count; BRCA cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg06544989 chr22:39130855 UNC84B -0.37 -8.3 -0.31 6.1e-16 Menopause (age at onset); BRCA cis rs270601 0.633 rs4535443 chr5:131572561 A/G cg12564285 chr5:131593104 PDLIM4 0.39 9.64 0.36 1.24e-20 Acylcarnitine levels; BRCA cis rs6910061 0.830 rs13190922 chr6:11125002 T/C cg27233058 chr6:11094804 LOC221710 0.51 8.73 0.33 2.24e-17 Diabetic kidney disease; BRCA cis rs12477438 0.798 rs1349779 chr2:99645055 T/C cg08885076 chr2:99613938 TSGA10 -0.56 -12.54 -0.44 2.01e-32 Chronic sinus infection; BRCA cis rs473651 0.904 rs508274 chr2:239337723 G/A cg14266287 chr2:239334506 ASB1 -0.34 -8.15 -0.31 1.87e-15 Multiple system atrophy; BRCA cis rs703842 1.000 rs10747783 chr12:58176614 T/C cg00677455 chr12:58241039 CTDSP2 0.63 14.34 0.49 1.22e-40 Multiple sclerosis; BRCA cis rs2832191 0.632 rs2246777 chr21:30309586 T/C cg24692254 chr21:30365293 RNF160 -0.74 -19.71 -0.61 6.03e-68 Dental caries; BRCA cis rs778371 0.723 rs10210953 chr2:233698830 G/A cg08000102 chr2:233561755 GIGYF2 -0.83 -20.3 -0.63 4.66e-71 Schizophrenia; BRCA cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg16339924 chr4:17578868 LAP3 0.56 13.89 0.48 1.65e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9287719 0.967 rs6432114 chr2:10744930 C/T cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg04025307 chr7:1156635 C7orf50 0.47 9.16 0.34 7.1e-19 Bronchopulmonary dysplasia; BRCA trans rs35110281 0.616 rs2236666 chr21:45109856 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.28 0.31 7.26e-16 Mean corpuscular volume; BRCA trans rs6582630 0.519 rs7294292 chr12:38349540 C/T cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 9.43e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg22117172 chr7:91764530 CYP51A1 0.24 8.08 0.3 3.21e-15 Breast cancer; BRCA cis rs6835098 0.962 rs10027704 chr4:174083107 T/C cg08422745 chr4:174089978 GALNT7 -0.8 -18.39 -0.59 6.24e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs2580764 0.566 rs2968794 chr2:55290651 C/G cg09592903 chr2:55203963 RTN4 -0.36 -9.33 -0.35 1.67e-19 Mean platelet volume; BRCA cis rs877282 0.947 rs957642 chr10:773966 C/T cg17470449 chr10:769945 NA 0.51 9.67 0.36 9.84e-21 Uric acid levels; BRCA cis rs113835537 0.597 rs11227523 chr11:66305938 C/T cg24851651 chr11:66362959 CCS 0.47 8.84 0.33 9.15e-18 Airway imaging phenotypes; BRCA cis rs9875589 0.509 rs6442423 chr3:14016062 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.33 8.77 0.33 1.58e-17 Ovarian reserve; BRCA cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.71 -0.36 7.16e-21 Body mass index; BRCA cis rs6545883 0.965 rs11887205 chr2:61774473 T/G cg15711740 chr2:61764176 XPO1 -0.57 -14.38 -0.49 8.34e-41 Tuberculosis; BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg01262667 chr19:19385393 TM6SF2 0.4 10.49 0.38 7.51e-24 Tonsillectomy; BRCA cis rs6973256 0.897 rs4731970 chr7:133326602 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.85 -0.33 8.79e-18 Intelligence (multi-trait analysis); BRCA cis rs6433895 1.000 rs6759865 chr2:182017385 A/G cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg00908189 chr16:619842 PIGQ 0.71 18.45 0.59 2.82e-61 Height; BRCA cis rs2953145 0.545 rs2975751 chr2:241521135 G/A cg07929629 chr2:241523174 NA 0.54 11.59 0.42 2.64e-28 Bipolar disorder; BRCA cis rs4481887 0.893 rs1339990 chr1:248509495 C/T cg13385794 chr1:248469461 NA -0.27 -8.14 -0.31 2.06e-15 Common traits (Other); BRCA cis rs4664304 0.620 rs12692568 chr2:160718440 T/C cg14819504 chr2:160761413 LY75 0.34 8.36 0.31 3.88e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg08085267 chr17:45401833 C17orf57 -0.67 -14.99 -0.51 9.59e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9814567 0.806 rs6806810 chr3:134323522 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.77 -0.55 1.45e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs8114671 0.528 rs6119542 chr20:33484545 G/T cg24642439 chr20:33292090 TP53INP2 0.43 9.12 0.34 9.85e-19 Height; BRCA cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg00071950 chr4:10020882 SLC2A9 -0.48 -11.57 -0.42 3.03e-28 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg22105103 chr4:187893119 NA 0.37 11.84 0.42 2.26e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs10392 0.850 rs725322 chr20:37563352 C/T cg16355469 chr20:37678765 NA 0.47 8.04 0.3 4.35e-15 Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis; BRCA cis rs9649465 1.000 rs10215473 chr7:123380681 C/G cg04330084 chr7:123175371 IQUB -0.3 -8.27 -0.31 7.73e-16 Migraine; BRCA cis rs1595825 0.891 rs73056877 chr2:198816724 A/C cg19156104 chr2:198669113 PLCL1 -0.44 -8.13 -0.31 2.26e-15 Ulcerative colitis; BRCA cis rs12682352 0.715 rs332039 chr8:8723651 C/G cg06636001 chr8:8085503 FLJ10661 0.58 12.24 0.44 4.42e-31 Neuroticism; BRCA cis rs2070488 0.965 rs35553573 chr3:38441439 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.48 0.61 1.02e-66 Electrocardiographic conduction measures; BRCA cis rs9682041 0.660 rs13089074 chr3:170113481 G/A cg11886554 chr3:170076028 SKIL 0.51 10.13 0.37 1.76e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs7191700 0.511 rs8058983 chr16:11360849 A/G cg00044050 chr16:11439710 C16orf75 -0.42 -9.78 -0.36 3.92e-21 Multiple sclerosis; BRCA cis rs10197940 0.662 rs4335940 chr2:152275304 A/G cg06191203 chr2:152266755 RIF1 0.31 9.06 0.34 1.61e-18 Lung cancer; BRCA cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg13736514 chr6:26305472 NA -0.37 -11.91 -0.43 1.09e-29 Educational attainment; BRCA trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.83 0.45 1.04e-33 Corneal astigmatism; BRCA cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg25208724 chr1:156163844 SLC25A44 1.07 35.26 0.81 4.84e-152 Testicular germ cell tumor; BRCA cis rs7631605 0.935 rs2241031 chr3:37090274 C/T cg15934958 chr3:37212084 LRRFIP2 0.41 9.54 0.35 3.08e-20 Cerebrospinal P-tau181p levels; BRCA cis rs2032447 0.798 rs807214 chr6:26061769 G/C cg03517284 chr6:25882590 NA -0.46 -9.64 -0.36 1.22e-20 Intelligence (multi-trait analysis); BRCA cis rs2075371 1.000 rs432487 chr7:133990114 T/G cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.61e-66 Mean platelet volume; BRCA cis rs61931739 0.517 rs1817760 chr12:34106060 A/G cg06521331 chr12:34319734 NA -0.62 -11.19 -0.4 1.14e-26 Morning vs. evening chronotype; BRCA cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg11752832 chr7:134001865 SLC35B4 0.44 9.62 0.36 1.53e-20 Mean platelet volume; BRCA cis rs708547 1.000 rs2412770 chr4:57794660 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.49 -8.37 -0.31 3.68e-16 Response to bleomycin (chromatid breaks); BRCA cis rs2742417 0.565 rs2673031 chr3:45756986 A/G cg04837898 chr3:45731254 SACM1L -0.4 -8.15 -0.31 1.87e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs1153858 1.000 rs67744121 chr15:45677237 C/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.72 0.42 7.51e-29 Homoarginine levels; BRCA cis rs597539 0.654 rs619727 chr11:68627535 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 16.75 0.55 1.79e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 11.99 0.43 5.16e-30 Platelet count; BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg00166722 chr3:10149974 C3orf24 0.65 12.8 0.45 1.54e-33 Alzheimer's disease; BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg23533926 chr12:111358616 MYL2 -0.44 -9.18 -0.34 5.78e-19 Extrinsic epigenetic age acceleration; BRCA cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg17063962 chr7:91808500 NA 0.54 12.41 0.44 7.41e-32 Breast cancer; BRCA cis rs10927875 0.541 rs1048334 chr1:16340761 T/C cg22431228 chr1:16359049 CLCNKA -0.43 -9.53 -0.35 3.09e-20 Dilated cardiomyopathy; BRCA cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg23719950 chr11:63933701 MACROD1 -0.58 -9.62 -0.36 1.48e-20 Mean platelet volume; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg13880726 chr7:1868755 MAD1L1 0.41 7.94 0.3 9.03e-15 Bipolar disorder and schizophrenia; BRCA cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg17136484 chr7:158649327 WDR60 0.4 8.62 0.32 5.38e-17 Height; BRCA cis rs36051895 0.632 rs10118789 chr9:5141178 G/A cg02405213 chr9:5042618 JAK2 -0.49 -9.11 -0.34 1.08e-18 Pediatric autoimmune diseases; BRCA cis rs10927875 0.541 rs1739844 chr1:16343322 T/C cg22431228 chr1:16359049 CLCNKA -0.44 -9.82 -0.36 2.63e-21 Dilated cardiomyopathy; BRCA cis rs4389656 0.767 rs369769 chr5:6720712 T/C cg10857441 chr5:6722123 POLS -0.25 -7.82 -0.3 2.22e-14 Coronary artery disease; BRCA cis rs9986765 1.000 rs76467433 chr7:142824852 C/T cg21852589 chr7:142981689 TMEM139 0.62 10.13 0.37 1.75e-22 Cancer;Dermatomyositis; BRCA cis rs344364 0.602 rs12325217 chr16:1887108 A/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.39 -8.24 -0.31 9.86e-16 Glomerular filtration rate in chronic kidney disease; BRCA cis rs870825 0.616 rs2696037 chr4:185610940 C/T cg04058563 chr4:185651563 MLF1IP -0.67 -12.72 -0.45 3.24e-33 Blood protein levels; BRCA cis rs2637030 0.559 rs2637027 chr5:52980471 G/A cg06476337 chr5:52856530 NDUFS4 0.36 8.27 0.31 7.87e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg00080972 chr5:178986291 RUFY1 0.41 10.68 0.39 1.33e-24 Lung cancer; BRCA cis rs10751667 0.643 rs10902244 chr11:949981 A/G ch.11.42038R chr11:967971 AP2A2 0.5 15.89 0.53 3.78e-48 Alzheimer's disease (late onset); BRCA cis rs1005277 0.579 rs2474594 chr10:38426661 G/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.81e-26 Extrinsic epigenetic age acceleration; BRCA cis rs4742903 0.967 rs2417485 chr9:106867106 A/C cg21169611 chr9:106856078 SMC2 0.36 9.55 0.35 2.75e-20 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs10992471 0.603 rs12336415 chr9:95195458 G/T cg14631576 chr9:95140430 CENPP -0.39 -9.32 -0.35 1.83e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs3857536 0.740 rs9354392 chr6:66894555 G/T cg07460842 chr6:66804631 NA -0.45 -8.74 -0.33 2.05e-17 Blood trace element (Cu levels); BRCA trans rs561341 1.000 rs483301 chr17:30293398 G/T cg27661571 chr11:113659931 NA -0.8 -12.01 -0.43 4.07e-30 Hip circumference adjusted for BMI; BRCA cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg15556689 chr8:8085844 FLJ10661 0.49 13.87 0.48 2.01e-38 Mood instability; BRCA cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg23029597 chr12:123009494 RSRC2 -0.46 -9.42 -0.35 8.37e-20 Body mass index; BRCA cis rs7560272 0.538 rs7599453 chr2:73937901 T/G cg20560298 chr2:73613845 ALMS1 0.35 8.99 0.34 2.67e-18 Schizophrenia; BRCA cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg09469691 chr10:81107165 PPIF 0.52 11.07 0.4 3.68e-26 Height; BRCA trans rs6951245 1.000 rs78185558 chr7:1090183 G/C cg13565492 chr6:43139072 SRF -0.69 -10.06 -0.37 3.5e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7246657 0.943 rs3745765 chr19:37854235 G/T cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg21782813 chr7:2030301 MAD1L1 0.34 9.05 0.34 1.75e-18 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg21724239 chr8:58056113 NA 0.58 9.4 0.35 9.72e-20 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.534 rs10844800 chr12:34230734 A/G cg13010199 chr12:38710504 ALG10B 0.49 9.56 0.35 2.56e-20 Morning vs. evening chronotype; BRCA cis rs9287719 0.967 rs7563894 chr2:10754649 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.0 -0.3 6.08e-15 Prostate cancer; BRCA cis rs897984 0.762 rs2054213 chr16:30971810 A/G cg02466173 chr16:30829666 NA 0.49 11.07 0.4 3.6e-26 Dementia with Lewy bodies; BRCA trans rs587242 0.910 rs56339673 chr1:97000555 C/T cg10631902 chr5:14652156 NA 0.34 8.4 0.32 2.83e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs10504229 0.639 rs2318145 chr8:58114867 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -9.01 -0.34 2.38e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.601 rs330105 chr6:8543981 A/C cg07606381 chr6:8435919 SLC35B3 0.64 14.05 0.49 2.87e-39 Motion sickness; BRCA cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg06115741 chr20:33292138 TP53INP2 -0.36 -8.1 -0.31 2.74e-15 Glomerular filtration rate (creatinine); BRCA cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 14.05 0.49 2.79e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs57221529 0.766 rs1399381 chr5:589853 G/T cg11887960 chr12:57824829 NA 0.53 8.26 0.31 8.2e-16 Lung disease severity in cystic fibrosis; BRCA cis rs2617583 0.967 rs2550947 chr5:1450506 T/C cg07151155 chr5:1473589 LPCAT1 -0.42 -9.14 -0.34 8.43e-19 Breast cancer; BRCA cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.42e-68 Mean platelet volume; BRCA cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg16850897 chr7:100343110 ZAN 0.38 8.41 0.32 2.68e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 9.33 0.35 1.68e-19 Platelet count; BRCA cis rs2549003 1.000 rs2549009 chr5:131826765 T/C cg21138405 chr5:131827807 IRF1 -0.38 -11.78 -0.42 3.84e-29 Asthma (sex interaction); BRCA trans rs61931739 0.517 rs10772139 chr12:34186178 A/T cg26384229 chr12:38710491 ALG10B 0.68 14.54 0.5 1.35e-41 Morning vs. evening chronotype; BRCA cis rs7618915 0.547 rs62253703 chr3:52632357 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.33 0.38 3.11e-23 Bipolar disorder; BRCA cis rs13064411 0.518 rs6438160 chr3:113217591 A/C cg18753928 chr3:113234510 CCDC52 -0.41 -9.18 -0.34 6.13e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA trans rs11098499 0.954 rs56270433 chr4:120406030 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.93 -0.3 9.81e-15 Corneal astigmatism; BRCA cis rs1506636 0.708 rs7788702 chr7:123237421 C/T cg03229431 chr7:123269106 ASB15 0.6 13.16 0.46 3.52e-35 Plateletcrit;Platelet count; BRCA cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg24397884 chr7:158709396 WDR60 -0.98 -24.72 -0.7 3.33e-95 Height; BRCA cis rs1005277 0.579 rs9418322 chr10:38377296 G/T cg25427524 chr10:38739819 LOC399744 -0.7 -16.88 -0.56 4.06e-53 Extrinsic epigenetic age acceleration; BRCA cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg11584989 chr19:19387371 SF4 -0.59 -13.38 -0.47 3.44e-36 Bipolar disorder; BRCA cis rs7264396 0.779 rs2425162 chr20:34429974 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.62 -0.5 5.66e-42 Total cholesterol levels; BRCA cis rs2625529 0.526 rs7179942 chr15:72563074 C/G cg16672083 chr15:72433130 SENP8 0.61 14.51 0.5 1.95e-41 Red blood cell count; BRCA cis rs1801251 1.000 rs12990821 chr2:233617585 C/G cg08000102 chr2:233561755 GIGYF2 0.64 13.9 0.48 1.5e-38 Coronary artery disease; BRCA cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08109568 chr15:31115862 NA -0.43 -10.16 -0.37 1.44e-22 Huntington's disease progression; BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -7.86 -0.3 1.67e-14 Developmental language disorder (linguistic errors); BRCA trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg03929089 chr4:120376271 NA 0.65 12.83 0.45 1.07e-33 Coronary artery disease; BRCA cis rs2841277 0.802 rs2841269 chr14:105386149 C/G cg21017887 chr14:105400489 NA 0.59 14.76 0.5 1.2e-42 Rheumatoid arthritis; BRCA cis rs858239 1.000 rs156407 chr7:23315639 G/A cg23682824 chr7:23144976 KLHL7 0.4 9.83 0.36 2.39e-21 Cerebrospinal fluid biomarker levels; BRCA cis rs6598955 0.671 rs11247880 chr1:26568926 G/A cg04990556 chr1:26633338 UBXN11 0.55 8.62 0.32 5.06e-17 Obesity-related traits; BRCA trans rs7395662 0.517 rs11039885 chr11:48647107 A/G cg00717180 chr2:96193071 NA -0.41 -11.31 -0.41 3.64e-27 HDL cholesterol; BRCA trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -8.86 -0.33 7.7e-18 Coronary artery disease; BRCA trans rs1969363 0.509 rs8189633 chr12:38065155 C/G cg06521331 chr12:34319734 NA -0.54 -9.73 -0.36 5.76e-21 Morning vs. evening chronotype; BRCA cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24308560 chr3:49941425 MST1R 0.39 8.51 0.32 1.25e-16 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg06238570 chr21:40685208 BRWD1 -0.4 -8.11 -0.31 2.53e-15 Menarche (age at onset); BRCA cis rs2066819 1.000 rs17118409 chr12:56630764 G/A cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs7395581 0.918 rs3781622 chr11:47348702 T/C cg25783544 chr11:47291846 MADD 0.41 9.23 0.34 3.87e-19 HDL cholesterol; BRCA cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.38 -0.38 1.93e-23 Initial pursuit acceleration; BRCA cis rs10751667 1.000 rs7927156 chr11:970607 A/G cg01483505 chr11:975446 AP2A2 0.31 8.13 0.31 2.26e-15 Alzheimer's disease (late onset); BRCA cis rs9790314 0.664 rs723757 chr3:160645435 C/T cg03342759 chr3:160939853 NMD3 0.43 8.24 0.31 9.7e-16 Morning vs. evening chronotype; BRCA cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.02 0.43 3.78e-30 Multiple sclerosis; BRCA trans rs7613875 0.600 rs2856237 chr3:50158774 A/G cg21659725 chr3:3221576 CRBN -0.36 -8.74 -0.33 1.99e-17 Body mass index; BRCA cis rs28735056 0.596 rs3744879 chr18:77679006 G/C cg20368463 chr18:77673604 PQLC1 -0.51 -12.54 -0.44 2.2e-32 Schizophrenia; BRCA cis rs2180341 0.920 rs1073931 chr6:127681762 A/T cg27446573 chr6:127587934 RNF146 0.86 20.0 0.62 1.76e-69 Breast cancer; BRCA trans rs911555 0.723 rs4906320 chr14:103876925 T/C cg17675199 chr6:35436792 RPL10A -0.3 -8.0 -0.3 5.78e-15 Intelligence (multi-trait analysis); BRCA cis rs3770081 1.000 rs2241435 chr2:86360916 C/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.58 -7.95 -0.3 8.54e-15 Facial emotion recognition (sad faces); BRCA trans rs61931739 0.534 rs10844816 chr12:34248533 C/A cg13010199 chr12:38710504 ALG10B 0.49 9.5 0.35 4.29e-20 Morning vs. evening chronotype; BRCA cis rs12681288 0.523 rs11137122 chr8:954702 A/G cg04851639 chr8:1020857 NA -0.3 -8.43 -0.32 2.26e-16 Schizophrenia; BRCA cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 10.65 0.39 1.64e-24 Rheumatoid arthritis; BRCA cis rs2239547 0.657 rs12496077 chr3:52886241 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -9.22 -0.34 4.43e-19 Schizophrenia; BRCA trans rs783540 0.835 rs8030185 chr15:83391537 G/A cg18393722 chr15:85113863 UBE2QP1 0.27 8.3 0.31 5.99e-16 Schizophrenia; BRCA cis rs10501293 1.000 rs4755698 chr11:43123536 G/T cg03447554 chr11:43094025 NA -0.47 -8.57 -0.32 7.95e-17 Cognitive performance; BRCA cis rs11764590 0.715 rs9639202 chr7:2087315 G/A cg02743256 chr7:2109353 MAD1L1 -0.45 -8.05 -0.3 4.16e-15 Neuroticism; BRCA cis rs3213545 0.659 rs2259690 chr12:121457914 T/G cg02403541 chr12:121454288 C12orf43 0.59 12.8 0.45 1.51e-33 Subjective well-being;Cardiovascular disease risk factors; BRCA cis rs40363 0.645 rs250631 chr16:3523215 G/C cg22508957 chr16:3507546 NAT15 0.43 9.71 0.36 6.71e-21 Tuberculosis; BRCA trans rs2288327 0.643 rs16866334 chr2:179336672 A/G cg14011486 chr1:26737247 LIN28 0.48 8.03 0.3 4.68e-15 Atrial fibrillation; BRCA cis rs586533 0.846 rs1003122 chr11:99496892 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs72627509 0.951 rs72606404 chr4:57841213 G/C cg26694713 chr4:57773883 REST 0.45 8.16 0.31 1.82e-15 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs754466 0.874 rs55910200 chr10:79665173 T/C cg17075019 chr10:79541650 NA -0.68 -12.98 -0.46 2.33e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs847649 0.692 rs7800548 chr7:102481842 C/T cg18108683 chr7:102477205 FBXL13 0.55 14.21 0.49 4.87e-40 Morning vs. evening chronotype; BRCA trans rs11098499 0.863 rs6534139 chr4:120449456 A/G cg25214090 chr10:38739885 LOC399744 -0.58 -12.65 -0.45 7.2e-33 Corneal astigmatism; BRCA cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg26031613 chr14:104095156 KLC1 -0.42 -8.33 -0.31 4.82e-16 Schizophrenia; BRCA cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg11822812 chr5:140052017 DND1 -0.29 -8.17 -0.31 1.6e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12756686 chr19:29218302 NA 0.57 10.93 0.4 1.36e-25 Methadone dose in opioid dependence; BRCA cis rs34779708 0.733 rs16935945 chr10:35540320 A/C cg03585969 chr10:35415529 CREM 0.45 9.19 0.34 5.29e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg09658497 chr7:2847517 GNA12 -0.45 -9.94 -0.37 1e-21 Height; BRCA cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.28 0.61 1.18e-65 Cognitive function; BRCA trans rs3780486 0.846 rs10116966 chr9:33122370 T/A cg04842962 chr6:43655489 MRPS18A 1.12 38.54 0.84 7.46e-169 IgG glycosylation; BRCA trans rs12310956 0.532 rs11052952 chr12:33988048 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.37 0.35 1.2e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs4292342 chr4:98959870 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.25e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg06484146 chr7:12443880 VWDE -0.7 -9.7 -0.36 7.38e-21 Coronary artery disease; BRCA cis rs6500602 0.627 rs9934267 chr16:4534366 G/C cg08645402 chr16:4508243 NA 0.4 9.33 0.35 1.78e-19 Schizophrenia; BRCA cis rs1403694 0.695 rs1050274 chr3:186435370 G/A cg12454167 chr3:186435060 KNG1 0.29 7.9 0.3 1.23e-14 Blood protein levels; BRCA cis rs7552404 1.000 rs11161510 chr1:76210289 A/G cg10523679 chr1:76189770 ACADM -0.78 -16.42 -0.54 8.12e-51 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1451375 0.698 rs68143668 chr7:50638110 C/T cg18232548 chr7:50535776 DDC 0.38 9.14 0.34 8.18e-19 Malaria; BRCA cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.33 -0.31 4.95e-16 Aortic root size; BRCA cis rs847577 0.609 rs6465658 chr7:97816638 C/G cg21770322 chr7:97807741 LMTK2 0.65 19.7 0.61 7.01e-68 Breast cancer; BRCA cis rs6831352 0.918 rs13143133 chr4:100054970 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs11252926 0.510 rs4881371 chr10:554514 G/A cg03684893 chr10:554711 DIP2C -0.43 -10.39 -0.38 1.73e-23 Psychosis in Alzheimer's disease; BRCA cis rs3820928 0.874 rs6717168 chr2:227901342 C/T cg11843606 chr2:227700838 RHBDD1 -0.37 -8.35 -0.31 4.31e-16 Pulmonary function; BRCA cis rs6484504 0.625 rs796341 chr11:31414151 G/A cg14844989 chr11:31128820 NA 0.44 9.38 0.35 1.16e-19 Red blood cell count; BRCA cis rs6582630 0.519 rs12372510 chr12:38293074 T/C cg26384229 chr12:38710491 ALG10B 0.68 15.91 0.53 2.84e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs7267979 0.932 rs372678 chr20:25465248 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.29 8.34 0.31 4.5e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg24812749 chr6:127587940 RNF146 0.68 15.55 0.52 1.82e-46 Breast cancer; BRCA trans rs60843830 0.596 rs17041320 chr2:112051 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.46 9.01 0.34 2.3e-18 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4237845 0.837 rs7954591 chr12:58299037 A/G cg00677455 chr12:58241039 CTDSP2 0.45 10.73 0.39 8.25e-25 Intelligence (multi-trait analysis); BRCA cis rs2011503 1.000 rs754256 chr19:19578591 A/G cg15839431 chr19:19639596 YJEFN3 0.41 9.09 0.34 1.26e-18 Bipolar disorder; BRCA cis rs7666738 0.830 rs13148363 chr4:98847498 T/C cg17366294 chr4:99064904 C4orf37 0.43 10.08 0.37 2.77e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs78456975 0.943 rs7602369 chr2:1574754 T/C cg01028140 chr2:1542097 TPO -0.7 -13.25 -0.46 1.46e-35 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg25036284 chr2:26402008 FAM59B -0.65 -10.18 -0.37 1.16e-22 Gut microbiome composition (summer); BRCA cis rs3806843 0.897 rs2531338 chr5:140136957 A/T cg11822812 chr5:140052017 DND1 -0.31 -8.58 -0.32 7.33e-17 Depressive symptoms (multi-trait analysis); BRCA trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.2 -0.56 9.32e-55 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.667 rs78426057 chr1:152964528 T/C cg21543102 chr1:152974771 SPRR3 -0.3 -8.49 -0.32 1.44e-16 Inflammatory skin disease; BRCA cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg18876405 chr7:65276391 NA 0.7 18.56 0.59 7.85e-62 Calcium levels; BRCA cis rs6456156 0.526 rs1854853 chr6:167533062 A/G cg07741184 chr6:167504864 NA -0.28 -8.34 -0.31 4.56e-16 Primary biliary cholangitis; BRCA cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg01877450 chr7:97915802 BRI3 -0.37 -8.57 -0.32 7.96e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 29.51 0.76 2.06e-121 Chronic sinus infection; BRCA cis rs10876993 0.728 rs1082503 chr12:58036717 G/A cg18357645 chr12:58087776 OS9 0.44 12.47 0.44 4.44e-32 Celiac disease or Rheumatoid arthritis; BRCA trans rs7829975 0.564 rs2921060 chr8:8317817 G/T cg16141378 chr3:129829833 LOC729375 0.33 7.83 0.3 1.98e-14 Mood instability; BRCA cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.43 -0.52 6.69e-46 Breast cancer; BRCA cis rs6942756 0.806 rs10248810 chr7:128993806 G/A cg02491457 chr7:128862824 NA -0.58 -12.04 -0.43 3.07e-30 White matter hyperintensity burden; BRCA cis rs6089829 0.851 rs6089827 chr20:61668845 C/T cg08045932 chr20:61659980 NA 0.49 11.18 0.4 1.22e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs66887589 0.616 rs6822808 chr4:120217365 C/A cg09307838 chr4:120376055 NA 0.44 9.12 0.34 9.32e-19 Diastolic blood pressure; BRCA cis rs4073582 0.555 rs521109 chr11:66030948 G/A cg16950941 chr11:66035639 RAB1B 0.46 12.3 0.44 2.24e-31 Gout; BRCA cis rs1499972 0.941 rs62263123 chr3:117632263 G/A cg07612923 chr3:117604196 NA 0.6 8.15 0.31 1.97e-15 Schizophrenia; BRCA trans rs6479891 1.000 rs2616629 chr10:65213816 T/C cg14819942 chr15:35414228 NA 0.35 8.55 0.32 8.78e-17 Arthritis (juvenile idiopathic); BRCA cis rs12586317 0.620 rs8021414 chr14:35581480 T/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.43 -0.38 1.21e-23 Psoriasis; BRCA cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg23711669 chr6:146136114 FBXO30 0.78 18.73 0.6 1.03e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs3106136 0.527 rs10016806 chr4:95158495 G/T cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.14 -0.37 1.72e-22 Capecitabine sensitivity; BRCA cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg07636037 chr3:49044803 WDR6 0.98 29.26 0.76 4.4e-120 Parkinson's disease; BRCA cis rs7592578 0.679 rs59929070 chr2:191327852 A/G cg10560079 chr2:191398806 TMEM194B -0.68 -12.88 -0.45 6.29e-34 Diastolic blood pressure; BRCA cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg00277334 chr10:82204260 NA -0.44 -8.32 -0.31 5.36e-16 Post bronchodilator FEV1; BRCA cis rs7809799 0.850 rs10248890 chr7:98752384 A/G cg05967295 chr7:98741636 SMURF1 -0.78 -7.83 -0.3 2.1e-14 Ulcerative colitis; BRCA cis rs7572733 0.534 rs1401095 chr2:198779867 C/T cg00792783 chr2:198669748 PLCL1 -0.48 -10.32 -0.38 3.35e-23 Dermatomyositis; BRCA cis rs4631830 0.720 rs12763717 chr10:51500874 C/G cg16070123 chr10:51489643 NA 0.35 7.81 0.3 2.28e-14 Prostate-specific antigen levels; BRCA trans rs11227306 0.934 rs7102454 chr11:65594820 C/T cg17712092 chr4:129076599 LARP1B -0.44 -9.33 -0.35 1.76e-19 DNA methylation (variation); BRCA cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg18404041 chr3:52824283 ITIH1 -0.36 -9.36 -0.35 1.29e-19 Schizophrenia; BRCA cis rs13315871 1.000 rs75828026 chr3:58346736 C/T cg20936604 chr3:58311152 NA -0.63 -8.07 -0.3 3.46e-15 Cholesterol, total; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11229555 1.000 rs7102510 chr11:58371283 T/G cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs3733585 0.699 rs4408959 chr4:9948868 C/T cg26043149 chr18:55253948 FECH -0.36 -7.92 -0.3 1.05e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7945718 0.934 rs11022478 chr11:12741104 T/C cg25843174 chr11:12811716 TEAD1 0.21 7.86 0.3 1.61e-14 Educational attainment (years of education); BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 18.05 0.58 3.74e-59 Platelet count; BRCA trans rs9291683 0.595 rs3733585 chr4:10036339 A/G cg26043149 chr18:55253948 FECH 0.42 8.99 0.34 2.84e-18 Bone mineral density; BRCA cis rs4671400 0.571 rs6738482 chr2:61494901 A/G cg15711740 chr2:61764176 XPO1 0.42 8.83 0.33 1.03e-17 3-hydroxypropylmercapturic acid levels in smokers; BRCA trans rs10506458 0.915 rs12426017 chr12:63396272 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.24 -20.65 -0.63 5.99e-73 Hemostatic factors and hematological phenotypes; BRCA cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs637571 0.522 rs12797319 chr11:65735672 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 13.19 0.46 2.73e-35 Eosinophil percentage of white cells; BRCA cis rs2479724 0.935 rs7753507 chr6:41784094 C/T cg17623882 chr6:41773611 USP49 0.37 10.32 0.38 3.39e-23 Menarche (age at onset); BRCA cis rs12367572 0.965 rs10748405 chr12:45321341 C/G cg04608330 chr12:45269318 NELL2 -0.61 -13.46 -0.47 1.62e-36 Gut microbiome composition (summer); BRCA cis rs7560272 0.501 rs12624267 chr2:73986931 C/T cg20560298 chr2:73613845 ALMS1 0.34 8.74 0.33 1.98e-17 Schizophrenia; BRCA cis rs870825 0.655 rs1527870 chr4:185616631 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.17 0.56 1.32e-54 Blood protein levels; BRCA cis rs4074536 0.622 rs10737736 chr1:116315536 G/A cg21648376 chr1:116311395 CASQ2 -0.55 -9.08 -0.34 1.37e-18 QRS duration; BRCA cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg00579200 chr11:133705235 NA -0.37 -7.82 -0.3 2.23e-14 Childhood ear infection; BRCA cis rs911119 1.000 rs1064039 chr20:23618427 C/T cg16589663 chr20:23618590 CST3 0.47 8.83 0.33 9.75e-18 Chronic kidney disease; BRCA cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.92 -0.33 4.83e-18 Monocyte percentage of white cells; BRCA cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg12193833 chr17:30244370 NA -0.61 -9.2 -0.34 4.97e-19 Hip circumference adjusted for BMI; BRCA cis rs12618769 0.597 rs72819965 chr2:99023719 G/C cg10123293 chr2:99228465 UNC50 0.44 8.76 0.33 1.81e-17 Bipolar disorder; BRCA cis rs208515 0.592 rs10944862 chr6:66674215 C/T cg07460842 chr6:66804631 NA 0.87 15.64 0.53 6.69e-47 Exhaled nitric oxide levels; BRCA cis rs4595586 0.545 rs11615584 chr12:39409350 C/G cg26384229 chr12:38710491 ALG10B 0.56 11.67 0.42 1.12e-28 Morning vs. evening chronotype; BRCA cis rs10504229 0.638 rs6981055 chr8:58113941 T/C cg08219700 chr8:58056026 NA 0.44 7.92 0.3 1.08e-14 Developmental language disorder (linguistic errors); BRCA cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg14019146 chr3:50243930 SLC38A3 0.41 10.05 0.37 3.63e-22 Body mass index; BRCA cis rs9463078 0.774 rs10948222 chr6:45244415 T/C cg25276700 chr6:44698697 NA -0.35 -7.9 -0.3 1.2e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1941023 0.584 rs2233252 chr11:60157107 T/G cg08716584 chr11:60157161 MS4A7 -0.44 -10.63 -0.39 2.13e-24 Congenital heart disease (maternal effect); BRCA cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg18198730 chr1:247681584 NA 0.5 11.33 0.41 3.1e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs17376456 1.000 rs12187701 chr5:93522290 A/G cg25358565 chr5:93447407 FAM172A 1.25 19.09 0.6 1.28e-64 Diabetic retinopathy; BRCA cis rs600231 0.708 rs682845 chr11:65254201 A/G cg01292856 chr11:65242576 NA 0.36 9.24 0.34 3.66e-19 Bone mineral density; BRCA cis rs7524258 0.900 rs12035586 chr1:7273020 C/T cg07173049 chr1:7289937 CAMTA1 -0.37 -8.79 -0.33 1.41e-17 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs6831352 0.918 rs17218560 chr4:100060794 C/T cg13256891 chr4:100009986 ADH5 0.5 9.39 0.35 1.05e-19 Alcohol dependence; BRCA cis rs921968 0.542 rs588182 chr2:219412335 C/A cg02176678 chr2:219576539 TTLL4 0.46 11.91 0.43 1.07e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg11764359 chr7:65958608 NA 0.68 15.5 0.52 3.05e-46 Aortic root size; BRCA cis rs2439831 0.850 rs28564774 chr15:44125475 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.82 0.45 1.27e-33 Lung cancer in ever smokers; BRCA cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.86e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3806843 0.900 rs2563286 chr5:140125199 T/A cg26395211 chr5:140044315 WDR55 0.35 7.84 0.3 1.86e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg22963979 chr7:1858916 MAD1L1 -0.39 -8.16 -0.31 1.74e-15 Bipolar disorder and schizophrenia; BRCA cis rs36051895 0.632 rs12336875 chr9:5138404 C/A cg02405213 chr9:5042618 JAK2 -0.42 -8.1 -0.31 2.76e-15 Pediatric autoimmune diseases; BRCA trans rs9329221 0.736 rs2001338 chr8:10251217 A/G cg06636001 chr8:8085503 FLJ10661 0.51 10.07 0.37 3e-22 Neuroticism; BRCA cis rs701145 0.556 rs191651 chr3:153973887 T/G cg12800244 chr3:153838788 SGEF 0.43 8.54 0.32 1.01e-16 Coronary artery disease; BRCA cis rs7772486 0.846 rs2748496 chr6:146321829 T/A cg23711669 chr6:146136114 FBXO30 0.65 14.9 0.51 2.65e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg18132916 chr6:79620363 NA -0.46 -10.16 -0.37 1.42e-22 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.868 rs2262574 chr5:140123635 G/T cg26395211 chr5:140044315 WDR55 0.36 8.01 0.3 5.3e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs4819052 1.000 rs4818769 chr21:46667451 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 14.87 0.51 3.65e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9790314 0.638 rs13064176 chr3:160644181 A/T cg03342759 chr3:160939853 NMD3 -0.45 -8.62 -0.32 5.12e-17 Morning vs. evening chronotype; BRCA cis rs10504073 0.669 rs11779189 chr8:50030592 C/G cg00325661 chr8:49890786 NA -0.37 -10.9 -0.4 1.75e-25 Blood metabolite ratios; BRCA cis rs34779708 0.897 rs9787566 chr10:35279455 T/A cg03585969 chr10:35415529 CREM 0.56 11.51 0.41 5.36e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg26818010 chr10:134567672 INPP5A -0.63 -13.42 -0.47 2.27e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs1997103 0.954 rs940880 chr7:55392619 C/G cg20935933 chr6:143382018 AIG1 0.6 11.57 0.42 3.12e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs11098499 0.615 rs59867181 chr4:120556467 C/T cg09307838 chr4:120376055 NA -0.54 -11.3 -0.41 3.99e-27 Corneal astigmatism; BRCA trans rs2739330 0.760 rs5751761 chr22:24243736 A/G cg06437703 chr8:37914619 EIF4EBP1 0.33 8.5 0.32 1.3e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 9.05 0.34 1.66e-18 Platelet count; BRCA cis rs4595586 0.525 rs11613788 chr12:39390710 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs34779708 0.733 rs4444023 chr10:35548354 G/A cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4853012 0.838 rs6715351 chr2:74346119 G/A cg20891558 chr2:74357851 NA 0.48 11.69 0.42 9.69e-29 Gestational age at birth (maternal effect); BRCA cis rs2235642 0.859 rs12599207 chr16:1606445 A/G cg09065629 chr16:1709722 CRAMP1L 0.37 8.47 0.32 1.63e-16 Coronary artery disease; BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.7 0.33 2.75e-17 Platelet count; BRCA cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg26384229 chr12:38710491 ALG10B 0.77 17.53 0.57 1.92e-56 Drug-induced liver injury (flucloxacillin); BRCA trans rs453301 0.571 rs330048 chr8:9087278 A/C cg21775007 chr8:11205619 TDH -0.37 -7.95 -0.3 8.58e-15 Joint mobility (Beighton score); BRCA cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg11279151 chr3:101281821 RG9MTD1 -0.42 -8.93 -0.33 4.58e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs466983 chr7:65520496 T/G cg18252515 chr7:66147081 NA -0.98 -13.86 -0.48 2.29e-38 Diabetic kidney disease; BRCA cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg06671706 chr8:8559999 CLDN23 0.44 8.46 0.32 1.85e-16 Obesity-related traits; BRCA cis rs2204008 0.837 rs2387317 chr12:38235319 T/C cg13010199 chr12:38710504 ALG10B 0.44 8.82 0.33 1.11e-17 Bladder cancer; BRCA cis rs11098499 0.739 rs9996382 chr4:120151012 C/T cg09307838 chr4:120376055 NA 0.47 8.97 0.33 3.33e-18 Corneal astigmatism; BRCA cis rs10992471 0.729 rs7042335 chr9:95122547 C/T cg14631576 chr9:95140430 CENPP -0.37 -8.96 -0.33 3.55e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg00908189 chr16:619842 PIGQ 0.7 17.52 0.57 1.96e-56 Height; BRCA cis rs870825 0.616 rs4443323 chr4:185629805 C/A cg20176042 chr4:185552304 CASP3 -0.53 -8.12 -0.31 2.38e-15 Blood protein levels; BRCA cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 5.04e-21 Alcohol dependence; BRCA cis rs1865721 0.848 rs12966327 chr18:73208445 C/T cg26385618 chr18:73139727 C18orf62 -0.36 -8.06 -0.3 3.84e-15 Intelligence; BRCA cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg26384229 chr12:38710491 ALG10B 0.83 22.45 0.66 9.57e-83 Heart rate; BRCA cis rs6088590 1.000 rs6120708 chr20:33335526 G/A cg24642439 chr20:33292090 TP53INP2 0.68 15.58 0.52 1.32e-46 Coronary artery disease; BRCA trans rs3960554 0.610 rs10265696 chr7:75766712 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 12.29 0.44 2.64e-31 Eotaxin levels; BRCA cis rs9814567 1.000 rs4498009 chr3:134198008 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.46 -0.61 1.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.68 -17.18 -0.56 1.15e-54 Multiple sclerosis; BRCA cis rs875971 0.528 rs801213 chr7:66014918 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.51 -9.67 -0.36 1.01e-20 Aortic root size; BRCA cis rs2836974 0.897 rs36113648 chr21:40555497 G/A cg11644478 chr21:40555479 PSMG1 0.89 21.0 0.64 7.43e-75 Cognitive function; BRCA cis rs7246657 0.714 rs12972195 chr19:37752505 T/C cg14683738 chr19:37701593 ZNF585B 0.47 8.07 0.3 3.43e-15 Coronary artery calcification; BRCA cis rs10193935 0.901 rs59890734 chr2:42595662 G/A cg27598129 chr2:42591480 NA -0.97 -15.46 -0.52 5.13e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs1059312 1.000 rs1059312 chr12:129278864 A/G cg23521905 chr12:129298690 SLC15A4;MGC16384 -0.25 -8.46 -0.32 1.83e-16 Systemic lupus erythematosus; BRCA trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg08975724 chr8:8085496 FLJ10661 -0.5 -10.58 -0.39 3.33e-24 Systolic blood pressure; BRCA cis rs1568889 1.000 rs61889054 chr11:28333000 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.6 11.44 0.41 1.02e-27 Bipolar disorder; BRCA cis rs9399137 0.507 rs11753673 chr6:135316476 T/C cg22676075 chr6:135203613 NA 0.44 8.6 0.32 6.06e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg03929089 chr4:120376271 NA 0.49 8.21 0.31 1.24e-15 Axial length; BRCA cis rs17253792 0.822 rs10137340 chr14:56050989 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.65 0.32 4.02e-17 Putamen volume; BRCA cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg08975724 chr8:8085496 FLJ10661 -0.45 -9.26 -0.34 3.02e-19 Systolic blood pressure; BRCA cis rs12762955 0.528 rs10903358 chr10:1102386 G/A cg26597838 chr10:835615 NA 0.88 13.49 0.47 1.1e-36 Response to angiotensin II receptor blocker therapy; BRCA cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.01 0.58 6.22e-59 Diabetic retinopathy; BRCA cis rs6582630 0.519 rs10880194 chr12:38302836 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs208520 0.690 rs10455594 chr6:66737894 C/G cg07460842 chr6:66804631 NA 0.99 19.85 0.62 1.08e-68 Exhaled nitric oxide output; BRCA cis rs2976388 0.507 rs2572874 chr8:143837219 C/T cg17888033 chr8:143858414 LYNX1 -0.34 -8.22 -0.31 1.17e-15 Urinary tract infection frequency; BRCA cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg06238570 chr21:40685208 BRWD1 -0.46 -8.95 -0.33 3.71e-18 Cognitive function; BRCA cis rs6920965 0.545 rs2326242 chr6:126174859 A/C cg05901451 chr6:126070800 HEY2 -0.35 -8.46 -0.32 1.76e-16 High light scatter reticulocyte count; BRCA cis rs9612 1.000 rs346534 chr19:44250831 A/G cg08581076 chr19:44259116 C19orf61 0.53 9.56 0.35 2.53e-20 Exhaled nitric oxide output; BRCA cis rs922692 0.744 rs12903203 chr15:79084933 T/C cg04896959 chr15:78267971 NA 0.36 8.48 0.32 1.55e-16 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs2288912 0.807 rs3760626 chr19:45457105 A/G cg20090143 chr19:45452003 APOC2 0.27 8.1 0.31 2.69e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3806843 0.868 rs2262574 chr5:140123635 G/T cg11822812 chr5:140052017 DND1 -0.32 -8.68 -0.32 3.31e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs752010 0.619 rs6703992 chr1:42115888 G/A cg06885757 chr1:42089581 HIVEP3 0.32 10.53 0.38 5.02e-24 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7918232 0.556 rs788209 chr10:27434716 G/T cg14240646 chr10:27532245 ACBD5 -0.74 -9.4 -0.35 9.27e-20 Breast cancer; BRCA cis rs9400271 0.632 rs9374069 chr6:109586334 A/G cg21918786 chr6:109611834 NA -0.31 -7.86 -0.3 1.64e-14 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs1997103 0.911 rs6949931 chr7:55391081 T/C cg20935933 chr6:143382018 AIG1 0.61 11.57 0.42 3.17e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6461049 0.646 rs3778970 chr7:2143208 C/A cg00106254 chr7:1943704 MAD1L1 -0.38 -9.25 -0.34 3.45e-19 Schizophrenia; BRCA cis rs7593730 0.666 rs10929973 chr2:161119907 A/G cg22609984 chr2:161126801 NA 0.43 9.28 0.34 2.51e-19 Type 2 diabetes; BRCA cis rs6545883 0.965 rs6545872 chr2:61724568 G/A cg15711740 chr2:61764176 XPO1 -0.55 -13.97 -0.48 6.42e-39 Tuberculosis; BRCA cis rs6831352 0.918 rs29001209 chr4:100052340 C/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg04450456 chr4:17643702 FAM184B 0.41 12.04 0.43 3.16e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10129255 0.500 rs9324092 chr14:107139823 A/G cg07958169 chr14:107095056 NA 0.42 9.04 0.34 1.85e-18 Kawasaki disease; BRCA cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg11764359 chr7:65958608 NA -0.75 -17.02 -0.56 7.54e-54 Aortic root size; BRCA cis rs9467773 0.595 rs2237236 chr6:26451553 A/G cg09904177 chr6:26538194 HMGN4 -0.36 -9.54 -0.35 2.89e-20 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs67478160 0.643 rs11624184 chr14:104240998 A/G cg01849466 chr14:104193079 ZFYVE21 -0.37 -9.6 -0.35 1.82e-20 Schizophrenia; BRCA cis rs67460515 0.563 rs1585481 chr3:160901481 C/T cg17135325 chr3:160939158 NMD3 0.44 8.41 0.32 2.59e-16 Parkinson's disease; BRCA cis rs9341808 0.683 rs9359409 chr6:80826897 C/G cg08355045 chr6:80787529 NA 0.37 9.37 0.35 1.24e-19 Sitting height ratio; BRCA cis rs4948102 0.655 rs4947533 chr7:56071282 T/C cg09872392 chr7:56161020 PHKG1 -0.39 -8.86 -0.33 8.09e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg14092988 chr3:52407081 DNAH1 0.38 8.77 0.33 1.61e-17 Bipolar disorder; BRCA cis rs9649465 0.551 rs10255400 chr7:123388036 G/A cg03229431 chr7:123269106 ASB15 -0.55 -12.45 -0.44 5.11e-32 Migraine; BRCA cis rs6484504 0.600 rs942272 chr11:31364368 C/T cg26647111 chr11:31128758 NA 0.45 9.59 0.35 1.97e-20 Red blood cell count; BRCA cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg18132916 chr6:79620363 NA -0.48 -10.89 -0.4 1.93e-25 Intelligence (multi-trait analysis); BRCA cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg00701064 chr4:6280414 WFS1 -0.65 -17.23 -0.56 6.59e-55 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg10057126 chr4:77819792 ANKRD56 0.66 14.86 0.51 3.87e-43 Emphysema distribution in smoking; BRCA cis rs425277 1.000 rs385039 chr1:2077409 C/T cg00981070 chr1:2046702 PRKCZ -0.29 -7.81 -0.3 2.32e-14 Height; BRCA cis rs875971 0.862 rs7809814 chr7:65615397 G/A cg18876405 chr7:65276391 NA -0.51 -11.78 -0.42 4.09e-29 Aortic root size; BRCA cis rs832540 0.629 rs6888317 chr5:56093307 A/G cg22800045 chr5:56110881 MAP3K1 -0.41 -8.24 -0.31 9.93e-16 Coronary artery disease; BRCA cis rs1371867 0.846 rs1660326 chr8:101290447 G/A cg06002616 chr8:101225028 SPAG1 -0.34 -8.28 -0.31 7.37e-16 Atrioventricular conduction; BRCA cis rs10465746 0.935 rs11163878 chr1:84442654 G/A cg10977910 chr1:84465055 TTLL7 0.52 10.55 0.39 4.28e-24 Obesity-related traits; BRCA cis rs2073300 1.000 rs17830565 chr20:23444805 G/A cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs724568 0.546 rs1549778 chr2:67951297 G/T cg14046302 chr2:67939758 NA -0.39 -10.38 -0.38 1.99e-23 Major depressive disorder (broad); BRCA cis rs6429082 0.608 rs4469707 chr1:235570634 T/C cg26050004 chr1:235667680 B3GALNT2 -0.53 -12.2 -0.43 6.3e-31 Adiposity; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg14820908 chr5:178986412 RUFY1 0.48 11.77 0.42 4.39e-29 Lung cancer; BRCA cis rs769267 1.000 rs2074090 chr19:19449686 G/T cg01262667 chr19:19385393 TM6SF2 -0.41 -10.72 -0.39 9.03e-25 Tonsillectomy; BRCA cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg21280719 chr6:42927975 GNMT 0.25 9.46 0.35 5.56e-20 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); BRCA cis rs2153535 0.580 rs6597325 chr6:8461053 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.21 0.49 5.09e-40 Motion sickness; BRCA trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.15 -0.37 1.46e-22 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs6744854 chr2:10747246 C/G cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.74e-15 Prostate cancer; BRCA cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg00012203 chr2:219082015 ARPC2 0.48 9.21 0.34 4.56e-19 Colorectal cancer; BRCA cis rs1953600 0.729 rs2819872 chr10:81906269 A/G cg04850286 chr10:81895943 PLAC9 0.33 10.18 0.37 1.15e-22 Sarcoidosis; BRCA cis rs9790314 1.000 rs4370045 chr3:160943865 A/G cg04691961 chr3:161091175 C3orf57 -0.58 -14.02 -0.49 3.77e-39 Morning vs. evening chronotype; BRCA cis rs490234 0.812 rs13300639 chr9:128407298 A/G cg14078157 chr9:128172775 NA -0.47 -10.43 -0.38 1.22e-23 Mean arterial pressure; BRCA cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg15212455 chr7:39170539 POU6F2 0.39 8.59 0.32 6.7e-17 IgG glycosylation; BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg05863683 chr7:1912471 MAD1L1 0.4 8.49 0.32 1.47e-16 Bipolar disorder and schizophrenia; BRCA cis rs9512730 0.527 rs11619784 chr13:27999643 A/G cg04070771 chr13:27998621 GTF3A 0.44 8.37 0.31 3.66e-16 Schizophrenia; BRCA cis rs7582180 0.602 rs7585582 chr2:100998030 G/C cg14675211 chr2:100938903 LONRF2 0.44 9.68 0.36 9.17e-21 Intelligence (multi-trait analysis); BRCA trans rs877282 0.898 rs34490091 chr10:765800 A/C cg22713356 chr15:30763199 NA 1.3 24.11 0.69 7.71e-92 Uric acid levels; BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg14004847 chr7:1930337 MAD1L1 -0.47 -8.95 -0.33 3.73e-18 Bipolar disorder and schizophrenia; BRCA trans rs6089829 0.925 rs3746748 chr20:61667526 C/T cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg26384229 chr12:38710491 ALG10B 0.64 17.08 0.56 3.92e-54 Heart rate; BRCA cis rs7103648 0.695 rs6485758 chr11:47530024 G/A cg20307385 chr11:47447363 PSMC3 0.8 19.04 0.6 2.3e-64 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2836974 0.897 rs2836928 chr21:40543320 C/T cg17971929 chr21:40555470 PSMG1 0.74 15.9 0.53 3.36e-48 Cognitive function; BRCA cis rs1190552 0.846 rs12883789 chr14:102954621 G/A cg18135206 chr14:102964638 TECPR2 0.45 8.88 0.33 6.6e-18 Blood protein levels; BRCA cis rs7829975 0.509 rs7838674 chr8:8797073 A/T cg15556689 chr8:8085844 FLJ10661 -0.41 -11.15 -0.4 1.71e-26 Mood instability; BRCA trans rs931812 0.895 rs4734493 chr8:101902169 C/T cg20993868 chr7:22813445 NA -0.52 -15.22 -0.52 7.6e-45 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs4478858 0.684 rs4949372 chr1:31738857 G/A cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.56 0.57 1.3e-56 Bladder cancer; BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.4 9.48 0.35 5.03e-20 Tonsillectomy; BRCA cis rs4664304 0.620 rs10186586 chr2:160715334 T/C cg14819504 chr2:160761413 LY75 0.34 8.48 0.32 1.59e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs10883723 0.810 rs2296582 chr10:104244139 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.59 17.26 0.56 4.69e-55 Allergic disease (asthma, hay fever or eczema); BRCA cis rs13046373 0.507 rs11088139 chr21:31978884 T/G cg16431978 chr21:31797932 KRTAP13-3 0.36 9.22 0.34 4.27e-19 HDL cholesterol; BRCA cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.71 -0.36 6.91e-21 Tonsillectomy; BRCA cis rs7264396 0.690 rs2425183 chr20:34450621 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.47 -0.52 4.4e-46 Total cholesterol levels; BRCA cis rs117623576 0.680 rs12269122 chr10:32367864 C/T cg03047570 chr10:32398778 NA -0.5 -7.9 -0.3 1.25e-14 Anti-saccade response; BRCA cis rs11583043 0.874 rs72734253 chr1:101380718 A/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.47 9.62 0.36 1.55e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7267979 0.934 rs2482913 chr20:25405086 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.58 -0.32 7.12e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg02951883 chr7:2050386 MAD1L1 -0.5 -10.86 -0.39 2.48e-25 Bipolar disorder and schizophrenia; BRCA trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.96 -0.56 1.56e-53 Intelligence (multi-trait analysis); BRCA trans rs3780486 0.846 rs3824458 chr9:33144809 C/T cg20290983 chr6:43655470 MRPS18A 1.09 37.56 0.83 7e-164 IgG glycosylation; BRCA cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg06671706 chr8:8559999 CLDN23 0.43 8.42 0.32 2.42e-16 Obesity-related traits; BRCA cis rs875971 0.638 rs7793569 chr7:66116633 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.52 -0.32 1.15e-16 Aortic root size; BRCA cis rs8072100 1.000 rs8065437 chr17:45721653 C/T cg25173405 chr17:45401733 C17orf57 -0.52 -11.19 -0.4 1.17e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg20203395 chr5:56204925 C5orf35 0.41 9.14 0.34 7.89e-19 Initial pursuit acceleration; BRCA cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg05985134 chr18:33552581 C18orf21 -0.65 -12.6 -0.45 1.18e-32 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs11098499 0.644 rs17517414 chr4:120262101 G/C cg25214090 chr10:38739885 LOC399744 0.42 9.71 0.36 6.98e-21 Corneal astigmatism; BRCA cis rs769267 0.566 rs9304962 chr19:19679992 G/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.42 -8.06 -0.3 3.9e-15 Tonsillectomy; BRCA cis rs593982 0.920 rs487264 chr11:65481465 A/C cg08755490 chr11:65554678 OVOL1 1.22 18.09 0.58 2.4e-59 Atopic dermatitis; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg00149659 chr3:10157352 C3orf10 0.75 13.37 0.47 4.08e-36 Alzheimer's disease; BRCA cis rs12950390 0.853 rs10445375 chr17:45864314 C/T cg03474202 chr17:45855739 NA 0.46 12.11 0.43 1.48e-30 IgG glycosylation; BRCA trans rs2262909 0.925 rs56073035 chr19:22276298 C/G cg17074339 chr11:11642133 GALNTL4 0.44 8.6 0.32 5.92e-17 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs990171 0.607 rs3917245 chr2:102775155 G/A cg22835712 chr2:102737379 NA 0.53 9.2 0.34 5.15e-19 Lymphocyte counts; BRCA cis rs62158211 1.000 rs1807282 chr2:114110036 A/T cg17784749 chr2:114082611 LOC440839 0.52 9.07 0.34 1.44e-18 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; BRCA cis rs10883723 0.810 rs2296585 chr10:104245549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 18.0 0.58 6.64e-59 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.09 0.4 2.92e-26 Bipolar disorder; BRCA cis rs829880 0.789 rs1096146 chr12:98850966 A/G cg25150519 chr12:98850993 NA 0.63 14.04 0.49 3.33e-39 Colonoscopy-negative controls vs population controls; BRCA trans rs57221529 0.766 rs17563576 chr5:560476 A/G cg25482853 chr8:67687455 SGK3 1.0 17.42 0.57 6.34e-56 Lung disease severity in cystic fibrosis; BRCA cis rs4363385 0.693 rs2339487 chr1:152983528 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.08 -0.34 1.38e-18 Inflammatory skin disease; BRCA cis rs7071206 0.947 rs4979905 chr10:79416367 C/T cg23888215 chr10:79422304 NA -0.56 -10.56 -0.39 3.9e-24 Bone mineral density; BRCA cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg24812749 chr6:127587940 RNF146 0.86 20.25 0.63 7.96e-71 Breast cancer; BRCA trans rs877282 0.898 rs11253340 chr10:764786 G/T cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs11758351 0.660 rs75156165 chr6:26235699 C/A cg01420254 chr6:26195488 NA 0.55 8.54 0.32 9.51e-17 Gout;Renal underexcretion gout; BRCA cis rs734999 0.545 rs6684865 chr1:2546229 A/G cg18854424 chr1:2615690 NA -0.35 -8.46 -0.32 1.87e-16 Ulcerative colitis; BRCA cis rs477692 0.905 rs514963 chr10:131419707 C/T cg05714579 chr10:131428358 MGMT 0.56 13.71 0.48 1.05e-37 Response to temozolomide; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.55 -9.94 -0.37 9.93e-22 Renal function-related traits (BUN); BRCA cis rs10870270 1.000 rs4880250 chr10:133773919 G/A cg17892150 chr10:133769511 PPP2R2D -0.72 -15.37 -0.52 1.39e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg24642439 chr20:33292090 TP53INP2 0.7 15.82 0.53 7.88e-48 Coronary artery disease; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13126279 chr21:47581558 C21orf56 -0.48 -10.83 -0.39 3.37e-25 Testicular germ cell tumor; BRCA cis rs2070488 0.662 rs7375040 chr3:38469116 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.53 12.39 0.44 9.04e-32 Electrocardiographic conduction measures; BRCA cis rs796364 0.806 rs79897806 chr2:201073968 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.59 -8.63 -0.32 5.03e-17 Schizophrenia; BRCA cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg11764359 chr7:65958608 NA -0.75 -16.59 -0.55 1.12e-51 Aortic root size; BRCA trans rs6582630 0.555 rs11182429 chr12:38526679 A/C cg06521331 chr12:34319734 NA -0.45 -8.62 -0.32 5.4e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -14.26 -0.49 2.92e-40 Cognitive function; BRCA cis rs4730250 0.707 rs3729877 chr7:106787065 T/G cg02696742 chr7:106810147 HBP1 0.58 9.5 0.35 3.97e-20 Osteoarthritis; BRCA cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg05623727 chr3:50126028 RBM5 -0.48 -11.64 -0.42 1.63e-28 Body mass index; BRCA cis rs4481887 0.927 rs10749651 chr1:248472930 T/C cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs2016266 0.964 rs1609474 chr12:53676814 C/T cg26875137 chr12:53738046 NA -0.36 -9.63 -0.36 1.41e-20 Bone mineral density (spine);Bone mineral density; BRCA trans rs12310956 0.515 rs1830086 chr12:33958874 C/T cg26384229 chr12:38710491 ALG10B 0.66 13.95 0.48 8.57e-39 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs4699589 chr4:98973889 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.34 -8.38 -0.31 3.48e-16 Personality dimensions; BRCA cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg16339924 chr4:17578868 LAP3 0.66 15.54 0.52 1.99e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg03354898 chr7:1950403 MAD1L1 -0.4 -8.5 -0.32 1.32e-16 Bipolar disorder and schizophrenia; BRCA cis rs939658 0.805 rs12902831 chr15:79433171 G/A cg17916960 chr15:79447300 NA -0.42 -10.65 -0.39 1.75e-24 Refractive error; BRCA cis rs7973719 0.833 rs7962563 chr12:7353514 G/A cg07052231 chr12:7363540 PEX5 0.36 8.18 0.31 1.54e-15 IgG glycosylation; BRCA cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg05985134 chr18:33552581 C18orf21 0.64 11.51 0.41 5.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4478858 0.735 rs3806255 chr1:31791578 A/G cg00250761 chr1:31883323 NA -0.33 -8.54 -0.32 9.88e-17 Alcohol dependence; BRCA cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg13175981 chr1:150552382 MCL1 0.41 9.18 0.34 5.73e-19 Tonsillectomy; BRCA cis rs2668423 0.922 rs3826942 chr19:1360575 A/G cg02639931 chr19:1387894 NDUFS7 0.63 13.9 0.48 1.37e-38 Nonalcoholic fatty liver disease; BRCA cis rs3925075 0.966 rs7195915 chr16:31344455 A/G cg02846316 chr16:31340340 ITGAM 0.54 13.33 0.47 5.89e-36 IgA nephropathy; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg08888203 chr3:10149979 C3orf24 0.63 13.81 0.48 3.82e-38 Alzheimer's disease; BRCA cis rs965469 0.545 rs6051845 chr20:3402792 A/G cg25506879 chr20:3388711 C20orf194 -0.44 -9.32 -0.35 1.79e-19 IFN-related cytopenia; BRCA cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg27478167 chr7:817139 HEATR2 -0.41 -8.69 -0.33 3.03e-17 Cerebrospinal P-tau181p levels; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.59 -12.31 -0.44 2.1e-31 Lymphocyte counts; BRCA cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg24829409 chr8:58192753 C8orf71 -0.61 -12.57 -0.45 1.5e-32 Developmental language disorder (linguistic errors); BRCA cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg03517284 chr6:25882590 NA 0.53 12.22 0.44 5.47e-31 Blood metabolite levels; BRCA trans rs7395662 0.591 rs10838972 chr11:48611400 A/G cg00717180 chr2:96193071 NA -0.38 -10.34 -0.38 2.9e-23 HDL cholesterol; BRCA cis rs6912958 0.781 rs7761814 chr6:88188309 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.49 -0.32 1.46e-16 Monocyte percentage of white cells; BRCA cis rs763121 0.889 rs2267390 chr22:38889657 C/T cg14440974 chr22:39074834 NA -0.35 -8.04 -0.3 4.35e-15 Menopause (age at onset); BRCA cis rs1862618 0.627 rs744023 chr5:56197078 C/T cg20203395 chr5:56204925 C5orf35 -0.6 -11.91 -0.43 1.1e-29 Initial pursuit acceleration; BRCA cis rs2576037 0.526 rs2187092 chr18:44526798 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -11.95 -0.43 7.75e-30 Personality dimensions; BRCA cis rs2274273 1.000 rs7142704 chr14:55630603 C/A cg04306507 chr14:55594613 LGALS3 0.32 8.85 0.33 8.49e-18 Protein biomarker; BRCA cis rs2191566 0.576 rs381888 chr19:44493005 C/T cg20607764 chr19:44506953 ZNF230 0.36 7.85 0.3 1.81e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.65 0.39 1.76e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs7617773 0.780 rs13090538 chr3:48370769 A/C cg11946769 chr3:48343235 NME6 0.68 14.02 0.48 4.16e-39 Coronary artery disease; BRCA cis rs7666738 0.830 rs2865980 chr4:99027422 T/G cg05340658 chr4:99064831 C4orf37 0.68 17.16 0.56 1.43e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.611 rs72783619 chr2:24311607 G/A cg20701182 chr2:24300061 SF3B14 0.71 13.61 0.47 3.21e-37 Lymphocyte counts; BRCA cis rs751728 0.664 rs943474 chr6:33749834 G/C cg25922239 chr6:33757077 LEMD2 0.5 12.69 0.45 4.58e-33 Crohn's disease; BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg00149659 chr3:10157352 C3orf10 0.71 12.54 0.44 2.2e-32 Alzheimer's disease; BRCA trans rs629535 0.767 rs72654073 chr8:70081231 G/A cg21567404 chr3:27674614 NA -1.02 -21.45 -0.65 2.82e-77 Dupuytren's disease; BRCA trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.821 rs11894756 chr2:24170214 A/G cg08917208 chr2:24149416 ATAD2B -0.64 -10.86 -0.39 2.59e-25 Lymphocyte counts; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg23708337 chr7:1209742 NA 0.5 8.61 0.32 5.65e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7582180 0.625 rs11892034 chr2:100938952 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs17361805 chr1:46813967 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.64 0.36 1.23e-20 Menopause (age at onset); BRCA cis rs2985684 0.894 rs4900927 chr14:50018741 G/T cg04989706 chr14:50066350 PPIL5 -0.47 -9.27 -0.34 2.81e-19 Carotid intima media thickness; BRCA cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg22601191 chr20:60968625 CABLES2 0.43 10.01 0.37 5.2e-22 Colorectal cancer; BRCA trans rs12517041 1.000 rs115818285 chr5:23291449 A/T ch.8.1293020R chr8:59333349 UBXN2B -0.45 -8.13 -0.31 2.16e-15 Calcium levels; BRCA trans rs561341 1.000 rs4795668 chr17:30244554 G/A cg20587970 chr11:113659929 NA -1.2 -21.73 -0.65 8.56e-79 Hip circumference adjusted for BMI; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1035144 0.546 rs2215981 chr14:81444967 G/A cg06600135 chr14:81408086 NA -0.48 -11.07 -0.4 3.59e-26 Male sexual orientation; BRCA cis rs7264396 0.790 rs6060562 chr20:34282053 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.6 -0.5 7.34e-42 Total cholesterol levels; BRCA trans rs9388451 0.591 rs1268792 chr6:126042124 G/A cg05039488 chr6:79577232 IRAK1BP1 0.42 9.44 0.35 7.13e-20 Brugada syndrome; BRCA cis rs7552404 0.628 rs5745442 chr1:76342858 T/G cg03433033 chr1:76189801 ACADM 0.7 13.27 0.46 1.13e-35 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg08859206 chr1:53392774 SCP2 0.48 10.61 0.39 2.5e-24 Monocyte count; BRCA cis rs2832077 0.824 rs4816333 chr21:30201777 C/G cg24692254 chr21:30365293 RNF160 -0.46 -7.96 -0.3 7.6e-15 Cognitive test performance; BRCA cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.5e-34 Asthma (sex interaction); BRCA cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg04607235 chr12:12878440 APOLD1 -0.69 -10.67 -0.39 1.38e-24 Systemic lupus erythematosus; BRCA cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 13.84 0.48 2.6e-38 Colorectal cancer; BRCA cis rs7249142 0.573 rs2238668 chr19:19282597 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.39 -0.32 3.03e-16 IgG glycosylation; BRCA cis rs1467026 0.563 rs12629928 chr3:12811796 C/T cg24848339 chr3:12840334 CAND2 0.4 10.04 0.37 3.96e-22 P wave duration; BRCA cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.52 8.26 0.31 8.48e-16 Renal function-related traits (BUN); BRCA cis rs477692 0.544 rs7894836 chr10:131442595 T/A cg24747557 chr10:131355152 MGMT 0.37 8.54 0.32 9.79e-17 Response to temozolomide; BRCA cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.91 0.74 1.14e-112 Chronic sinus infection; BRCA cis rs11718455 0.961 rs3846068 chr3:44029835 G/A cg08738300 chr3:44038990 NA 0.46 8.81 0.33 1.17e-17 Coronary artery disease; BRCA cis rs1401999 0.659 rs7622660 chr3:183753337 C/T cg20387954 chr3:183756860 HTR3D 0.57 12.4 0.44 8.74e-32 Anterior chamber depth; BRCA cis rs67478160 0.619 rs2368560 chr14:104273311 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.81 -0.39 3.99e-25 Schizophrenia; BRCA cis rs2204008 0.837 rs12581130 chr12:38319387 A/G cg26384229 chr12:38710491 ALG10B 0.69 16.31 0.54 2.86e-50 Bladder cancer; BRCA cis rs1577917 1.000 rs12215903 chr6:86675028 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -11.96 -0.43 6.63e-30 Response to antipsychotic treatment; BRCA cis rs4595586 0.545 rs11615718 chr12:39395335 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA trans rs9291683 0.567 rs12499857 chr4:9995376 G/A cg26043149 chr18:55253948 FECH 0.38 8.24 0.31 9.49e-16 Bone mineral density; BRCA cis rs3820928 0.935 rs113195824 chr2:227769139 A/G cg11843606 chr2:227700838 RHBDD1 -0.4 -8.89 -0.33 6.38e-18 Pulmonary function; BRCA cis rs561341 0.769 rs559228 chr17:30294527 T/C cg00745463 chr17:30367425 LRRC37B -0.53 -8.91 -0.33 5.36e-18 Hip circumference adjusted for BMI; BRCA trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg27661571 chr11:113659931 NA -0.81 -12.12 -0.43 1.41e-30 Hip circumference adjusted for BMI; BRCA cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg24692254 chr21:30365293 RNF160 -0.46 -10.16 -0.37 1.36e-22 Dental caries; BRCA cis rs72781680 1.000 rs72796389 chr2:24171761 A/G cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs7927592 0.913 rs7106339 chr11:68240241 C/T cg20283391 chr11:68216788 NA -0.48 -9.43 -0.35 7.5e-20 Total body bone mineral density; BRCA cis rs4664304 0.620 rs2048437 chr2:160712065 C/T cg18514922 chr2:160761262 LY75 0.34 7.97 0.3 7.22e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6782228 0.606 rs58977394 chr3:128337917 C/T cg16766828 chr3:128327626 NA -0.42 -9.53 -0.35 3.22e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs6860806 0.507 rs2631369 chr5:131705266 G/C cg07395648 chr5:131743802 NA 0.35 7.94 0.3 9.19e-15 Breast cancer; BRCA cis rs12200560 0.505 rs2015196 chr6:97075331 G/C cg06623918 chr6:96969491 KIAA0776 0.53 12.75 0.45 2.46e-33 Coronary heart disease; BRCA cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.78 0.39 5.07e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs17253792 0.818 rs78393484 chr14:56065802 T/C cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs34172651 0.583 rs200541 chr16:24733141 A/G cg06028605 chr16:24865363 SLC5A11 -0.43 -8.83 -0.33 9.71e-18 Intelligence (multi-trait analysis); BRCA cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg13073564 chr4:8508604 NA -0.36 -9.62 -0.36 1.47e-20 Response to antineoplastic agents; BRCA cis rs3125734 0.633 rs1864836 chr10:64028538 C/G cg19640130 chr10:64028056 RTKN2 -0.35 -9.76 -0.36 4.38e-21 Rheumatoid arthritis; BRCA trans rs7824557 0.670 rs2736381 chr8:11132766 A/T cg06636001 chr8:8085503 FLJ10661 -0.49 -9.78 -0.36 3.67e-21 Retinal vascular caliber; BRCA cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14240646 chr10:27532245 ACBD5 -0.63 -10.02 -0.37 4.98e-22 Breast cancer; BRCA cis rs778371 0.723 rs1022329 chr2:233591239 T/C cg08000102 chr2:233561755 GIGYF2 0.85 20.92 0.64 2.05e-74 Schizophrenia; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -17.68 -0.57 3.01e-57 Initial pursuit acceleration; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg08888203 chr3:10149979 C3orf24 0.65 13.74 0.48 7.58e-38 Alzheimer's disease; BRCA cis rs56235845 0.694 rs6875461 chr5:176754665 C/T cg06060754 chr5:176797920 RGS14 -0.56 -10.82 -0.39 3.7e-25 Hemoglobin concentration;Hematocrit; BRCA cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14298792 chr15:30685198 CHRFAM7A -0.42 -7.83 -0.3 2.05e-14 Huntington's disease progression; BRCA cis rs6860806 0.507 rs272880 chr5:131670178 C/T cg24060327 chr5:131705240 SLC22A5 -0.62 -11.78 -0.42 4.1e-29 Breast cancer; BRCA cis rs28374715 0.617 rs16971735 chr15:41563970 C/G cg18705301 chr15:41695430 NDUFAF1 -0.57 -12.37 -0.44 1.13e-31 Ulcerative colitis; BRCA cis rs2439831 0.850 rs28858500 chr15:44156942 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.69 12.25 0.44 4.05e-31 Lung cancer in ever smokers; BRCA cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg00898013 chr13:113819073 PROZ -0.36 -8.64 -0.32 4.44e-17 Platelet distribution width; BRCA cis rs9527 0.614 rs2153774 chr10:104881035 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA cis rs3824867 0.920 rs7105122 chr11:47449544 A/G cg20307385 chr11:47447363 PSMC3 0.48 10.74 0.39 7.8e-25 Mean corpuscular hemoglobin; BRCA cis rs4594175 0.926 rs7160948 chr14:51612537 T/A cg23942311 chr14:51606299 NA 0.32 7.81 0.3 2.41e-14 Cancer; BRCA trans rs1973993 0.745 rs6686016 chr1:96948002 G/A cg10631902 chr5:14652156 NA -0.49 -14.5 -0.5 2.26e-41 Weight; BRCA trans rs7746199 0.736 rs17750424 chr6:27701122 T/C cg01620082 chr3:125678407 NA -0.92 -10.32 -0.38 3.23e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs3762637 0.882 rs72958418 chr3:122160373 G/C cg24169773 chr3:122142474 KPNA1 -0.43 -8.05 -0.3 3.93e-15 LDL cholesterol levels; BRCA trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.92 -0.66 7.71e-80 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.2e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg23708337 chr7:1209742 NA 0.69 10.7 0.39 1.1e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6582630 0.593 rs11182590 chr12:38574274 A/T cg26384229 chr12:38710491 ALG10B 0.48 11.53 0.41 4.56e-28 Drug-induced liver injury (flucloxacillin); BRCA trans rs6479891 1.000 rs61853589 chr10:65187111 T/A cg14819942 chr15:35414228 NA 0.35 8.58 0.32 7.31e-17 Arthritis (juvenile idiopathic); BRCA cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs3784262 0.528 rs8027188 chr15:58334799 C/T cg12031962 chr15:58353849 ALDH1A2 -0.38 -9.93 -0.37 1.03e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg03452623 chr4:187889614 NA -0.33 -11.0 -0.4 6.68e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649465 0.967 rs3779261 chr7:123315174 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.29 -0.31 6.93e-16 Migraine; BRCA cis rs9309711 0.772 rs9752251 chr2:3489869 C/T cg10845886 chr2:3471009 TTC15 -0.77 -16.34 -0.54 2.14e-50 Neurofibrillary tangles; BRCA cis rs7927771 0.524 rs10838784 chr11:47882341 G/A cg20307385 chr11:47447363 PSMC3 0.41 9.32 0.35 1.89e-19 Subjective well-being; BRCA cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg05564831 chr3:52568323 NT5DC2 0.36 8.44 0.32 2.17e-16 Electroencephalogram traits; BRCA trans rs9858542 0.953 rs7622302 chr3:49547561 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.28 -0.34 2.54e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs11055034 0.560 rs2024385 chr12:12888438 A/T cg04607235 chr12:12878440 APOLD1 0.51 10.97 0.4 8.97e-26 Birth weight; BRCA cis rs9649465 0.967 rs12706546 chr7:123353414 G/A cg04330084 chr7:123175371 IQUB -0.33 -9.0 -0.34 2.54e-18 Migraine; BRCA cis rs9837602 1.000 rs28714363 chr3:99752068 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.16 0.4 1.52e-26 Breast cancer; BRCA cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg08807101 chr21:30365312 RNF160 0.44 9.5 0.35 4.27e-20 Pancreatic cancer; BRCA cis rs3008870 1.000 rs3008873 chr1:67425770 G/A cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.49 0.66 5.85e-83 Lymphocyte percentage of white cells; BRCA cis rs1577917 0.740 rs2842614 chr6:86306069 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.71 -0.45 3.79e-33 Response to antipsychotic treatment; BRCA trans rs7613875 0.580 rs2624819 chr3:50010571 G/T cg21659725 chr3:3221576 CRBN 0.33 8.08 0.3 3.32e-15 Body mass index; BRCA cis rs9309473 0.607 rs4641966 chr2:73590806 G/A cg20560298 chr2:73613845 ALMS1 -0.42 -11.03 -0.4 5.15e-26 Metabolite levels; BRCA cis rs10838687 0.867 rs2957873 chr11:47249294 G/A cg25783544 chr11:47291846 MADD -0.42 -8.38 -0.31 3.39e-16 Proinsulin levels; BRCA cis rs6570726 0.846 rs453834 chr6:145886261 T/C cg05347473 chr6:146136440 FBXO30 0.38 7.81 0.3 2.43e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.77 -19.13 -0.6 7.5e-65 Systemic lupus erythematosus; BRCA cis rs2070488 0.965 rs9829192 chr3:38569463 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.71 -19.31 -0.61 8.57e-66 Electrocardiographic conduction measures; BRCA cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg25237894 chr2:233734115 C2orf82 -0.45 -14.33 -0.49 1.34e-40 Coronary artery disease; BRCA trans rs61931739 0.534 rs2667447 chr12:34133468 C/A cg26384229 chr12:38710491 ALG10B 0.55 12.04 0.43 3.26e-30 Morning vs. evening chronotype; BRCA cis rs6598955 0.585 rs12138111 chr1:26590432 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.37 -0.31 3.62e-16 Obesity-related traits; BRCA cis rs35110281 0.667 rs2155722 chr21:45096206 A/G cg21573476 chr21:45109991 RRP1B 0.42 11.28 0.41 4.81e-27 Mean corpuscular volume; BRCA cis rs10751667 0.600 rs10902264 chr11:1003523 G/A cg01483505 chr11:975446 AP2A2 0.31 8.41 0.32 2.68e-16 Alzheimer's disease (late onset); BRCA cis rs1059312 0.500 rs10734964 chr12:129286486 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.5 -10.13 -0.37 1.88e-22 Systemic lupus erythematosus; BRCA cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg03934865 chr2:198174659 NA -0.38 -8.23 -0.31 1.03e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs9325144 0.555 rs4882358 chr12:38726640 A/G cg23762105 chr12:34175262 ALG10 -0.38 -9.72 -0.36 6.49e-21 Morning vs. evening chronotype; BRCA cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg06618935 chr21:46677482 NA -0.37 -8.09 -0.3 2.96e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.61 -10.38 -0.38 1.96e-23 Schizophrenia; BRCA cis rs6191 0.838 rs6877893 chr5:142727193 C/T cg08845721 chr5:142780693 NR3C1 -0.33 -7.81 -0.3 2.42e-14 Night sleep phenotypes; BRCA cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg11833968 chr6:79620685 NA -0.44 -9.71 -0.36 7.09e-21 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.679 rs8132135 chr21:46694782 C/T cg11663144 chr21:46675770 NA -0.47 -11.04 -0.4 4.77e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg08807101 chr21:30365312 RNF160 -0.53 -13.09 -0.46 7.1e-35 Dental caries; BRCA cis rs921968 0.643 rs1344645 chr2:219538019 A/C cg02176678 chr2:219576539 TTLL4 0.39 10.11 0.37 2.25e-22 Mean corpuscular hemoglobin concentration; BRCA cis rs12210905 0.688 rs12189640 chr6:27474657 T/C cg08851530 chr6:28072375 NA 0.81 8.01 0.3 5.53e-15 Hip circumference adjusted for BMI; BRCA cis rs218264 0.592 rs35978703 chr4:55368882 C/T cg17105814 chr4:55365203 NA -0.39 -8.19 -0.31 1.42e-15 Hemoglobin concentration;Hematocrit; BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.7 0.33 2.75e-17 Platelet count; BRCA trans rs4650994 0.544 rs4132058 chr1:178505557 A/C cg05059571 chr16:84539110 KIAA1609 -0.49 -11.12 -0.4 2.23e-26 HDL cholesterol levels;HDL cholesterol; BRCA cis rs2425143 1.000 rs6060557 chr20:34270266 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.0 -0.34 2.46e-18 Blood protein levels; BRCA cis rs4812048 0.649 rs6070705 chr20:57625231 A/C cg14073986 chr20:57617431 SLMO2 0.77 11.9 0.43 1.22e-29 Mean platelet volume; BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.42 0.66 1.41e-82 Platelet count; BRCA cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg16179182 chr5:140090404 VTRNA1-1 0.44 10.32 0.38 3.3e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs12618769 0.625 rs113342082 chr2:99034198 G/A cg10123293 chr2:99228465 UNC50 0.4 7.83 0.3 2.07e-14 Bipolar disorder; BRCA cis rs7011049 0.908 rs79560601 chr8:53853614 C/T cg26025543 chr8:53854495 NA 0.53 9.03 0.34 2.06e-18 Systolic blood pressure; BRCA cis rs34779708 0.966 rs11592567 chr10:35409369 C/T cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.98e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs317689 0.918 rs610192 chr12:69739941 T/C cg14784868 chr12:69753453 YEATS4 0.47 9.31 0.35 2.01e-19 Response to diuretic therapy; BRCA trans rs7618501 1.000 rs34614773 chr3:49753003 T/G cg21659725 chr3:3221576 CRBN -0.71 -21.92 -0.66 7.66e-80 Intelligence (multi-trait analysis); BRCA cis rs7301826 0.651 rs7295705 chr12:131301885 C/T cg11011512 chr12:131303247 STX2 0.51 13.6 0.47 3.41e-37 Plasma plasminogen activator levels; BRCA cis rs4074536 0.574 rs10127797 chr1:116287305 C/T cg21648376 chr1:116311395 CASQ2 -0.48 -8.43 -0.32 2.24e-16 QRS duration; BRCA cis rs778371 1.000 rs709937 chr2:233744021 A/G cg08000102 chr2:233561755 GIGYF2 0.74 15.78 0.53 1.33e-47 Schizophrenia; BRCA cis rs9814567 1.000 rs4368544 chr3:134300014 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.63 0.32 4.92e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg02780029 chr10:43622663 RET 0.36 8.05 0.3 3.97e-15 Hirschsprung disease; BRCA cis rs6701037 0.522 rs12094153 chr1:175094025 G/A cg00321850 chr1:175162397 KIAA0040 -0.32 -8.18 -0.31 1.58e-15 Alcohol dependence; BRCA cis rs3796352 1.000 rs11713859 chr3:53042080 C/A cg07884673 chr3:53033167 SFMBT1 0.88 10.31 0.38 3.62e-23 Immune reponse to smallpox (secreted IL-2); BRCA cis rs2882667 0.659 rs10056014 chr5:138256018 T/A cg04439458 chr5:138467593 SIL1 -0.31 -7.87 -0.3 1.58e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg20818283 chr2:191399100 TMEM194B 0.43 9.81 0.36 2.92e-21 Pulse pressure; BRCA cis rs4319547 0.695 rs10744211 chr12:122931820 A/G cg23029597 chr12:123009494 RSRC2 -0.6 -11.64 -0.42 1.58e-28 Body mass index; BRCA cis rs2011503 0.509 rs884480 chr19:19773923 G/A cg11584989 chr19:19387371 SF4 0.4 8.0 0.3 5.73e-15 Bipolar disorder; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg01305625 chr5:131593812 PDLIM4 0.37 9.14 0.34 7.87e-19 Acylcarnitine levels; BRCA cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.35e-64 Cognitive function; BRCA cis rs2046867 0.818 rs62249861 chr3:72867779 A/G cg25664220 chr3:72788482 NA -0.55 -11.66 -0.42 1.29e-28 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs11190604 0.767 rs11190520 chr10:102175309 T/C cg07080220 chr10:102295463 HIF1AN 0.5 10.18 0.37 1.13e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1865760 0.593 rs2097273 chr6:25941310 A/C cg03264133 chr6:25882463 NA -0.36 -7.92 -0.3 1.07e-14 Height; BRCA cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg03709012 chr19:19516395 GATAD2A 0.78 18.2 0.58 5.89e-60 Tonsillectomy; BRCA cis rs698833 0.501 rs10194161 chr2:44507213 A/G cg04920474 chr2:44395004 PPM1B -0.4 -9.39 -0.35 1.04e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg04944784 chr2:26401820 FAM59B -0.95 -16.58 -0.55 1.26e-51 Gut microbiome composition (summer); BRCA cis rs9443645 0.810 rs7753531 chr6:79789996 A/C cg18132916 chr6:79620363 NA -0.44 -9.8 -0.36 3.27e-21 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg08219700 chr8:58056026 NA 0.62 9.98 0.37 6.99e-22 Developmental language disorder (linguistic errors); BRCA cis rs7945718 0.875 rs7924501 chr11:12813870 A/G cg25843174 chr11:12811716 TEAD1 0.22 8.55 0.32 8.78e-17 Educational attainment (years of education); BRCA cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg19717773 chr7:2847554 GNA12 -0.43 -9.71 -0.36 6.85e-21 Height; BRCA cis rs752010 0.746 rs10749837 chr1:42089471 T/C cg06885757 chr1:42089581 HIVEP3 0.3 10.98 0.4 8.48e-26 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg24879335 chr3:133465180 TF 0.33 11.1 0.4 2.62e-26 Iron status biomarkers (transferrin levels); BRCA cis rs1865721 0.804 rs7243462 chr18:73147998 A/T cg26385618 chr18:73139727 C18orf62 -0.44 -10.63 -0.39 2.1e-24 Intelligence; BRCA cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs965469 0.779 rs6051740 chr20:3301165 T/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.73 -0.33 2.27e-17 IFN-related cytopenia; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg12564285 chr5:131593104 PDLIM4 0.35 9.48 0.35 4.85e-20 Breast cancer; BRCA trans rs11098499 0.866 rs7677068 chr4:120291704 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs698833 0.886 rs1056865 chr2:44546741 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 9.22 0.34 4.25e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs35110281 0.667 rs4819288 chr21:45120173 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.16 0.31 1.84e-15 Mean corpuscular volume; BRCA cis rs597539 0.615 rs583182 chr11:68678634 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 19.83 0.62 1.39e-68 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7103648 0.966 rs896817 chr11:47394305 A/G cg20307385 chr11:47447363 PSMC3 -0.82 -23.01 -0.67 8.25e-86 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs3772130 0.923 rs34865234 chr3:121560995 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.56 9.8 0.36 3.28e-21 Cognitive performance; BRCA cis rs9790314 0.690 rs7617204 chr3:160821969 A/G cg03342759 chr3:160939853 NMD3 -0.55 -11.73 -0.42 6.58e-29 Morning vs. evening chronotype; BRCA cis rs739401 0.611 rs7130841 chr11:3043658 A/G cg08508325 chr11:3079039 CARS -0.44 -16.22 -0.54 8.11e-50 Longevity; BRCA cis rs2836950 0.545 rs2297256 chr21:40558421 C/T cg11890956 chr21:40555474 PSMG1 -0.61 -13.72 -0.48 9.35e-38 Menarche (age at onset); BRCA cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg23422044 chr7:1970798 MAD1L1 -0.59 -10.61 -0.39 2.5e-24 Bipolar disorder; BRCA cis rs782590 0.902 rs7582278 chr2:55742924 C/G cg18811423 chr2:55921094 PNPT1 0.73 23.5 0.68 1.76e-88 Metabolic syndrome; BRCA cis rs7520050 0.843 rs1707334 chr1:46605728 A/C cg24296786 chr1:45957014 TESK2 0.38 8.4 0.32 2.93e-16 Red blood cell count;Reticulocyte count; BRCA cis rs28493229 0.522 rs2233152 chr19:41281016 C/T cg21869046 chr19:41225005 ITPKC 0.39 10.21 0.37 8.59e-23 Kawasaki disease; BRCA cis rs7666738 0.791 rs13111960 chr4:98976851 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.98e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.943 rs1035479 chr19:37893300 G/T cg23950597 chr19:37808831 NA 0.61 11.24 0.41 6.93e-27 Coronary artery calcification; BRCA cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg17971929 chr21:40555470 PSMG1 0.62 14.4 0.49 6.43e-41 Cognitive function; BRCA cis rs12824058 0.844 rs7956408 chr12:130807547 A/T cg26677194 chr12:130822605 PIWIL1 -0.48 -11.55 -0.42 3.74e-28 Menopause (age at onset); BRCA cis rs9858542 0.953 rs6446272 chr3:49463287 G/A cg03060546 chr3:49711283 APEH -0.54 -10.99 -0.4 7.4e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6028335 0.610 rs3752291 chr20:37570404 G/T cg16355469 chr20:37678765 NA 0.45 8.14 0.31 2e-15 Alcohol and nicotine co-dependence; BRCA cis rs7824557 0.872 rs1347410 chr8:11111242 G/A cg21775007 chr8:11205619 TDH -0.56 -11.53 -0.41 4.62e-28 Retinal vascular caliber; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.58 0.55 1.26e-51 Gut microbiome composition (summer); BRCA cis rs35110281 0.600 rs914198 chr21:45117456 A/C cg01579765 chr21:45077557 HSF2BP -0.44 -11.72 -0.42 6.85e-29 Mean corpuscular volume; BRCA cis rs877282 0.891 rs11253393 chr10:788824 G/T cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs13108904 0.870 rs3775094 chr4:1238859 G/A cg05665937 chr4:1216051 CTBP1 0.38 7.9 0.3 1.22e-14 Obesity-related traits; BRCA cis rs208520 0.507 rs9453585 chr6:66796668 C/T cg07460842 chr6:66804631 NA -1.14 -36.07 -0.82 3.01e-156 Exhaled nitric oxide output; BRCA cis rs35110281 0.600 rs11089092 chr21:45120994 A/C cg21573476 chr21:45109991 RRP1B -0.4 -10.66 -0.39 1.56e-24 Mean corpuscular volume; BRCA cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg25767906 chr1:53392781 SCP2 0.35 7.98 0.3 6.94e-15 Monocyte count; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg03354898 chr7:1950403 MAD1L1 -0.46 -9.61 -0.36 1.63e-20 Schizophrenia; BRCA cis rs17401966 0.965 rs12751375 chr1:10291874 C/G cg15208524 chr1:10270712 KIF1B 0.39 8.39 0.31 3.18e-16 Hepatocellular carcinoma; BRCA trans rs61931739 0.500 rs28624237 chr12:34457171 G/T cg13010199 chr12:38710504 ALG10B 0.49 9.56 0.35 2.42e-20 Morning vs. evening chronotype; BRCA cis rs9420 0.961 rs1647405 chr11:57477889 C/T cg19752551 chr11:57585705 CTNND1 -0.42 -10.79 -0.39 4.62e-25 Schizophrenia; BRCA cis rs4808199 0.895 rs10421505 chr19:19459554 C/T cg01262667 chr19:19385393 TM6SF2 0.41 8.94 0.33 4.01e-18 Nonalcoholic fatty liver disease; BRCA cis rs55665837 1.000 rs12295723 chr11:14450201 T/C cg19336497 chr11:14380999 RRAS2 -0.36 -9.47 -0.35 5.33e-20 Vitamin D levels; BRCA cis rs9807989 0.507 rs2293224 chr2:103035779 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.35 0.31 4.32e-16 Asthma; BRCA cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg20203395 chr5:56204925 C5orf35 -0.43 -9.66 -0.36 1.04e-20 Initial pursuit acceleration; BRCA cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg01475377 chr6:109611718 NA -0.44 -10.99 -0.4 7.28e-26 Reticulocyte fraction of red cells; BRCA cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg06627628 chr2:24431161 ITSN2 -0.82 -14.69 -0.5 2.71e-42 Asthma; BRCA cis rs10504229 0.683 rs62621195 chr8:58133964 G/A cg08219700 chr8:58056026 NA 0.46 8.36 0.31 3.92e-16 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg11266682 chr4:10021025 SLC2A9 0.48 12.73 0.45 3.03e-33 Bone mineral density; BRCA cis rs939658 1.000 rs4778935 chr15:79453282 T/C cg17916960 chr15:79447300 NA 0.39 9.73 0.36 6.11e-21 Refractive error; BRCA cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg20891558 chr2:74357851 NA 0.48 11.65 0.42 1.36e-28 Gestational age at birth (maternal effect); BRCA cis rs12477438 0.520 rs6542870 chr2:99796638 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs2463822 0.687 rs118012228 chr11:62155914 G/A cg06239285 chr11:62104954 ASRGL1 -0.68 -9.15 -0.34 7.5e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg07917127 chr4:99064746 C4orf37 -0.43 -8.04 -0.3 4.43e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1878931 0.559 rs1968055 chr16:3392053 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.63 13.66 0.48 1.77e-37 Body mass index (adult); BRCA cis rs2279817 1.000 rs10788681 chr1:18019524 C/A cg21791023 chr1:18019539 ARHGEF10L 0.56 16.5 0.55 3.44e-51 Neuroticism; BRCA cis rs2243480 0.711 rs1626926 chr7:65435792 C/T cg18252515 chr7:66147081 NA -0.84 -12.21 -0.43 5.66e-31 Diabetic kidney disease; BRCA cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg02475777 chr4:1388615 CRIPAK 0.54 10.91 0.4 1.58e-25 Longevity; BRCA cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg18357645 chr12:58087776 OS9 -0.33 -7.99 -0.3 6.21e-15 Multiple sclerosis; BRCA cis rs7264396 0.563 rs2425086 chr20:34302873 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.05e-30 Total cholesterol levels; BRCA cis rs1874326 0.545 rs2353348 chr7:138111275 T/C cg18008034 chr7:138118925 NA -0.45 -9.35 -0.35 1.47e-19 Quantitative traits; BRCA cis rs11098499 0.575 rs9996586 chr4:120326942 A/G cg09307838 chr4:120376055 NA 0.47 9.73 0.36 5.63e-21 Corneal astigmatism; BRCA trans rs7618501 1.000 rs7649348 chr3:49772375 G/A cg21659725 chr3:3221576 CRBN -0.71 -21.75 -0.65 6.15e-79 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.909 rs71614422 chr4:120359340 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.96 0.3 7.99e-15 Corneal astigmatism; BRCA cis rs453301 0.686 rs6748 chr8:8890802 C/T cg06636001 chr8:8085503 FLJ10661 -0.45 -9.47 -0.35 5.43e-20 Joint mobility (Beighton score); BRCA cis rs6088813 0.890 rs6088817 chr20:33984976 T/C cg14752227 chr20:34000481 UQCC -0.43 -9.08 -0.34 1.39e-18 Height; BRCA cis rs11190604 0.652 rs76629555 chr10:102191417 T/C cg07080220 chr10:102295463 HIF1AN 0.44 9.78 0.36 3.69e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12618769 0.597 rs7585939 chr2:99219206 T/A cg10123293 chr2:99228465 UNC50 0.42 8.49 0.32 1.44e-16 Bipolar disorder; BRCA cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg21395723 chr22:39101663 GTPBP1 -0.38 -8.45 -0.32 2.03e-16 Menopause (age at onset); BRCA cis rs4862750 1.000 rs4862750 chr4:187904043 C/T cg22105103 chr4:187893119 NA 0.37 11.84 0.42 2.26e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.579 rs2474563 chr10:38375938 T/C cg25427524 chr10:38739819 LOC399744 -0.7 -16.87 -0.56 4.23e-53 Extrinsic epigenetic age acceleration; BRCA cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.94 13.91 0.48 1.23e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.64 -0.68 3.1e-89 Gut microbiome composition (summer); BRCA cis rs11711311 0.712 rs3773684 chr3:113334488 A/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.33 -8.23 -0.31 1.02e-15 IgG glycosylation; BRCA cis rs311392 0.871 rs402088 chr8:55092805 A/G cg11783602 chr8:55087084 NA -0.31 -9.07 -0.34 1.49e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg19318889 chr4:1322082 MAEA 0.58 12.04 0.43 3.16e-30 Longevity; BRCA cis rs4808199 0.947 rs10404728 chr19:19595014 C/T cg03709012 chr19:19516395 GATAD2A 1.07 21.12 0.64 1.62e-75 Nonalcoholic fatty liver disease; BRCA cis rs6546550 0.694 rs12467361 chr2:70019127 G/A cg02498382 chr2:70120550 SNRNP27 -0.4 -8.09 -0.3 3.03e-15 Prevalent atrial fibrillation; BRCA cis rs7666738 0.830 rs62318470 chr4:98925846 A/C cg05340658 chr4:99064831 C4orf37 0.67 16.8 0.55 9.98e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1113500 0.933 rs745795 chr1:108629345 C/T cg06207961 chr1:108661230 NA 0.45 11.05 0.4 4.25e-26 Growth-regulated protein alpha levels; BRCA cis rs4689388 0.890 rs4342257 chr4:6290037 G/C cg00701064 chr4:6280414 WFS1 0.66 18.03 0.58 4.57e-59 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4820294 1.000 rs732856 chr22:38060691 C/G cg21798802 chr22:38057573 PDXP -0.48 -13.18 -0.46 2.98e-35 Fat distribution (HIV); BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs9790314 0.723 rs12631850 chr3:160883062 C/T cg03342759 chr3:160939853 NMD3 0.57 13.03 0.46 1.35e-34 Morning vs. evening chronotype; BRCA cis rs782590 0.807 rs782572 chr2:55912120 T/C cg18811423 chr2:55921094 PNPT1 0.77 26.88 0.73 4.57e-107 Metabolic syndrome; BRCA cis rs77106637 0.932 rs7109082 chr11:72707441 A/C cg03713592 chr11:72463424 ARAP1 0.76 11.5 0.41 5.72e-28 Type 2 diabetes; BRCA cis rs1707322 1.000 rs3922887 chr1:46473802 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.19e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11651000 0.947 rs11657376 chr17:45835984 A/T cg03474202 chr17:45855739 NA -0.43 -7.83 -0.3 2.06e-14 IgG glycosylation; BRCA cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.55 0.39 4.3e-24 Motion sickness; BRCA cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.55e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9309473 0.687 rs11126399 chr2:73613341 G/A cg20560298 chr2:73613845 ALMS1 -0.51 -13.67 -0.48 1.69e-37 Metabolite levels; BRCA cis rs1451375 0.572 rs3807558 chr7:50571022 A/G cg18232548 chr7:50535776 DDC -0.41 -8.79 -0.33 1.4e-17 Malaria; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg19723775 chr5:179050963 HNRNPH1 0.36 8.54 0.32 9.75e-17 Lung cancer; BRCA cis rs9463078 0.774 rs3923353 chr6:45256482 C/G cg25276700 chr6:44698697 NA -0.35 -7.9 -0.3 1.25e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA trans rs7647973 0.626 rs4855846 chr3:49683526 G/A cg21659725 chr3:3221576 CRBN -0.47 -8.44 -0.32 2.17e-16 Menarche (age at onset); BRCA cis rs9443645 0.901 rs1984195 chr6:79657391 G/A cg09184832 chr6:79620586 NA -0.52 -11.37 -0.41 2e-27 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.17 -0.31 1.65e-15 Total body bone mineral density; BRCA cis rs13217239 0.646 rs9393789 chr6:27067028 G/T cg12292205 chr6:26970375 C6orf41 -0.57 -12.69 -0.45 4.35e-33 Schizophrenia; BRCA cis rs17376456 0.877 rs13156865 chr5:93390908 C/A cg21475434 chr5:93447410 FAM172A 0.67 8.85 0.33 8.58e-18 Diabetic retinopathy; BRCA cis rs7772486 0.790 rs9399571 chr6:146282061 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.17 0.34 6.47e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6460942 1.000 rs6460936 chr7:12404913 T/C cg20607287 chr7:12443886 VWDE -0.56 -7.85 -0.3 1.77e-14 Coronary artery disease; BRCA cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg14631576 chr9:95140430 CENPP 0.35 8.47 0.32 1.72e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs10504229 1.000 rs56740825 chr8:58175617 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs1538970 0.816 rs3790583 chr1:45956828 C/G cg05343316 chr1:45956843 TESK2 0.7 14.57 0.5 1.02e-41 Platelet count; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs2549003 0.933 rs3846731 chr5:131814264 T/C cg02551604 chr5:131831745 NA -0.39 -14.62 -0.5 5.71e-42 Asthma (sex interaction); BRCA cis rs6565180 1.000 rs8049108 chr16:30376486 A/G cg17640201 chr16:30407289 ZNF48 -0.77 -20.31 -0.63 3.79e-71 Tonsillectomy; BRCA cis rs67460515 0.892 rs1382429 chr3:161015153 T/C cg04691961 chr3:161091175 C3orf57 -0.37 -7.92 -0.3 1.05e-14 Parkinson's disease; BRCA cis rs782590 0.620 rs4322879 chr2:55797033 G/T cg18811423 chr2:55921094 PNPT1 -0.51 -13.19 -0.46 2.6e-35 Metabolic syndrome; BRCA cis rs2204008 0.744 rs11180504 chr12:38236313 C/T cg13010199 chr12:38710504 ALG10B 0.44 8.84 0.33 9.41e-18 Bladder cancer; BRCA cis rs10504073 0.647 rs10435574 chr8:49996028 G/A cg00325661 chr8:49890786 NA 0.44 12.49 0.44 3.6e-32 Blood metabolite ratios; BRCA cis rs4478858 0.735 rs11436 chr1:31837320 T/C cg00250761 chr1:31883323 NA -0.32 -8.4 -0.32 2.9e-16 Alcohol dependence; BRCA cis rs1669338 0.588 rs55959448 chr3:3204000 C/T cg16797762 chr3:3221439 CRBN -0.66 -9.85 -0.36 2.03e-21 White matter integrity; BRCA cis rs4820539 0.708 rs5751591 chr22:23489042 G/A cg14186256 chr22:23484241 RTDR1 0.69 17.5 0.57 2.64e-56 Bone mineral density; BRCA trans rs11098499 0.954 rs71629403 chr4:120372567 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.91 -0.3 1.14e-14 Corneal astigmatism; BRCA cis rs9815354 1.000 rs73081353 chr3:41906448 T/A cg03022575 chr3:42003672 ULK4 0.51 8.31 0.31 5.54e-16 Pulse pressure;Diastolic blood pressure; BRCA cis rs9341808 0.718 rs9448886 chr6:80825901 C/T cg08355045 chr6:80787529 NA 0.37 9.37 0.35 1.24e-19 Sitting height ratio; BRCA cis rs9486719 1.000 rs2499809 chr6:96870110 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.98 0.46 2.34e-34 Migraine;Coronary artery disease; BRCA cis rs7208859 0.573 rs11654035 chr17:29136426 T/C cg13385521 chr17:29058706 SUZ12P 0.72 10.52 0.38 5.84e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7572733 0.534 rs11890137 chr2:198816662 G/A cg00792783 chr2:198669748 PLCL1 0.45 9.81 0.36 2.86e-21 Dermatomyositis; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg22920501 chr2:26401640 FAM59B 0.96 16.89 0.56 3.51e-53 Gut microbiome composition (summer); BRCA cis rs6840360 0.615 rs6535816 chr4:152614264 T/C cg22705602 chr4:152727874 NA -0.37 -9.93 -0.37 1.05e-21 Intelligence (multi-trait analysis); BRCA cis rs7760949 0.889 rs9382688 chr6:13926746 A/T cg27413430 chr6:13925136 RNF182 0.47 9.25 0.34 3.32e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.06 0.34 1.52e-18 Platelet count; BRCA cis rs9427116 0.502 rs3766922 chr1:154577055 A/C cg17218026 chr1:154582156 ADAR 0.27 8.17 0.31 1.66e-15 Blood protein levels; BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg24829409 chr8:58192753 C8orf71 -0.51 -8.32 -0.31 5.35e-16 Developmental language disorder (linguistic errors); BRCA cis rs13256369 0.901 rs12679831 chr8:8566411 T/G cg17143192 chr8:8559678 CLDN23 0.55 10.63 0.39 2.04e-24 Obesity-related traits; BRCA cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg22974920 chr21:40686053 BRWD1 -0.4 -8.88 -0.33 6.85e-18 Cognitive function; BRCA cis rs3749237 1.000 rs11130216 chr3:49736172 C/A cg03060546 chr3:49711283 APEH 0.48 10.34 0.38 2.7e-23 Resting heart rate; BRCA cis rs10411936 0.712 rs8103521 chr19:16589750 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.82 0.36 2.61e-21 White blood cell count;Multiple sclerosis; BRCA cis rs17092148 1.000 rs2425004 chr20:33405956 G/T cg16810054 chr20:33298113 TP53INP2 0.49 11.09 0.4 2.95e-26 Neuroticism; BRCA cis rs4423214 0.840 rs1540127 chr11:71179038 G/A cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs9467711 0.591 rs13201821 chr6:26057781 A/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.58 9.27 0.34 2.75e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg19077165 chr18:44547161 KATNAL2 0.39 8.15 0.31 1.86e-15 Personality dimensions; BRCA cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.38e-16 Schizophrenia; BRCA trans rs6598955 0.671 rs10902732 chr1:26606174 A/C cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs400736 0.930 rs225100 chr1:8066914 C/T cg25007680 chr1:8021821 PARK7 -0.47 -12.07 -0.43 2.23e-30 Response to antidepressants and depression; BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg04944784 chr2:26401820 FAM59B -0.69 -11.27 -0.41 5.27e-27 Gut microbiome composition (summer); BRCA cis rs713587 0.967 rs10182458 chr2:25150641 A/G cg04586622 chr2:25135609 ADCY3 0.41 10.22 0.37 8.4e-23 Body mass index in non-asthmatics; BRCA trans rs79976124 0.800 rs10944857 chr6:66637078 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.88 0.4 2.1e-25 Type 2 diabetes; BRCA cis rs7301826 0.651 rs10744484 chr12:131298506 T/G cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 3e-37 Plasma plasminogen activator levels; BRCA cis rs782590 0.537 rs12619903 chr2:55884106 T/A cg18811423 chr2:55921094 PNPT1 -0.52 -12.82 -0.45 1.19e-33 Metabolic syndrome; BRCA trans rs9325144 0.600 rs7312522 chr12:38730423 A/G cg23762105 chr12:34175262 ALG10 -0.38 -9.68 -0.36 9.08e-21 Morning vs. evening chronotype; BRCA cis rs4595586 0.545 rs7980848 chr12:39375166 G/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg13798912 chr7:905769 UNC84A -0.5 -7.96 -0.3 7.8e-15 Cerebrospinal P-tau181p levels; BRCA cis rs921968 0.643 rs586374 chr2:219383003 A/C cg02176678 chr2:219576539 TTLL4 0.39 10.47 0.38 8.85e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs12681288 0.963 rs7822955 chr8:1029090 C/T cg04851639 chr8:1020857 NA 0.32 9.68 0.36 8.67e-21 Schizophrenia; BRCA cis rs17604090 0.557 rs10279965 chr7:29717082 C/G cg19413766 chr7:29689036 LOC646762 -0.56 -9.01 -0.34 2.35e-18 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.17 0.31 1.67e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17021463 0.966 rs10856908 chr4:95222755 G/T cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.26 -0.38 5.58e-23 Testicular germ cell tumor; BRCA cis rs7975161 0.608 rs10861169 chr12:104610640 C/T cg25273343 chr12:104657179 TXNRD1 -0.38 -8.99 -0.34 2.7e-18 Toenail selenium levels; BRCA trans rs61931739 0.658 rs4476006 chr12:34237154 A/C cg26384229 chr12:38710491 ALG10B 0.44 10.71 0.39 9.92e-25 Morning vs. evening chronotype; BRCA trans rs1325195 0.770 rs965401 chr1:179133221 T/A cg11624085 chr17:8464688 MYH10 0.26 7.83 0.3 2.08e-14 IgE grass sensitization; BRCA cis rs2288073 0.965 rs13387930 chr2:24414400 A/G cg26838691 chr2:24397539 C2orf84 -0.48 -8.65 -0.32 4.29e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9787249 0.957 rs12239844 chr1:40217258 T/C cg02773041 chr1:40204384 PPIE 0.45 9.73 0.36 6.04e-21 Blood protein levels; BRCA cis rs9868809 0.505 rs13063223 chr3:48750340 G/A cg00383909 chr3:49044727 WDR6 0.6 10.99 0.4 7.23e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs9308433 0.553 rs9308435 chr1:214500166 C/T cg06198575 chr1:214491504 SMYD2 0.54 11.85 0.42 2.11e-29 IgG glycosylation; BRCA trans rs561341 1.000 rs564714 chr17:30318404 C/T cg20587970 chr11:113659929 NA -1.35 -24.74 -0.7 2.76e-95 Hip circumference adjusted for BMI; BRCA cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.52 -8.8 -0.33 1.25e-17 Body mass index (adult); BRCA cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg14004847 chr7:1930337 MAD1L1 0.43 8.86 0.33 8.16e-18 Bipolar disorder and schizophrenia; BRCA cis rs7258465 1.000 rs10164319 chr19:18569833 G/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.93 -0.33 4.55e-18 Breast cancer; BRCA cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg17509989 chr5:176798049 RGS14 0.63 12.66 0.45 6.41e-33 Hemoglobin concentration;Hematocrit; BRCA cis rs4919087 1.000 rs4919089 chr10:99087905 G/A cg25902810 chr10:99078978 FRAT1 -0.45 -9.36 -0.35 1.32e-19 Monocyte count; BRCA cis rs78707713 0.512 rs12412776 chr10:71179502 G/A cg12610070 chr10:71211762 TSPAN15 -0.31 -9.3 -0.35 2.18e-19 Venous thromboembolism; BRCA cis rs12142240 0.698 rs6696777 chr1:46810970 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2239547 0.603 rs9870898 chr3:53092375 A/G cg11645453 chr3:52864694 ITIH4 0.42 9.66 0.36 1.09e-20 Schizophrenia; BRCA cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.1 31.43 0.78 8.72e-132 Cognitive ability; BRCA cis rs1832871 0.644 rs56180963 chr6:158773990 G/A cg07165851 chr6:158734300 TULP4 0.64 12.73 0.45 2.92e-33 Height; BRCA cis rs17401966 1.000 rs12734551 chr1:10391536 A/C cg03954927 chr1:10346856 KIF1B 0.46 13.06 0.46 1.04e-34 Hepatocellular carcinoma; BRCA cis rs7618915 0.547 rs2164884 chr3:52629633 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.3 -0.31 6.42e-16 Bipolar disorder; BRCA cis rs8180040 0.726 rs7628747 chr3:47001990 A/T cg02527881 chr3:46936655 PTH1R -0.36 -8.69 -0.32 3.11e-17 Colorectal cancer; BRCA trans rs11098499 0.865 rs9996417 chr4:120295862 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.71e-15 Corneal astigmatism; BRCA cis rs9486719 1.000 rs12190508 chr6:96898269 T/C cg06623918 chr6:96969491 KIAA0776 -0.72 -12.94 -0.46 3.55e-34 Migraine;Coronary artery disease; BRCA cis rs736801 0.808 rs72797303 chr5:131796163 T/C cg14196790 chr5:131705035 SLC22A5 0.42 10.15 0.37 1.47e-22 Breast cancer;Mosquito bite size; BRCA cis rs1862618 0.853 rs252910 chr5:56192983 G/A cg12311346 chr5:56204834 C5orf35 -0.8 -15.86 -0.53 5.36e-48 Initial pursuit acceleration; BRCA trans rs7618501 0.602 rs2071206 chr3:50160109 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.32 -8.89 -0.33 6.1e-18 Intelligence (multi-trait analysis); BRCA cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg26384229 chr12:38710491 ALG10B 0.84 22.66 0.67 6.72e-84 Heart rate; BRCA cis rs4423214 0.840 rs1790339 chr11:71182761 C/A cg05163923 chr11:71159392 DHCR7 -0.56 -11.33 -0.41 3.01e-27 Vitamin D levels; BRCA cis rs34172651 0.517 rs2303084 chr16:24834581 G/C cg06028605 chr16:24865363 SLC5A11 0.4 8.07 0.3 3.6e-15 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg08917208 chr2:24149416 ATAD2B 0.92 13.65 0.48 2.16e-37 Lymphocyte counts; BRCA cis rs11105298 0.891 rs12369195 chr12:89934972 G/C cg00757033 chr12:89920650 WDR51B 0.52 10.53 0.38 5.03e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2629540 0.737 rs10901821 chr10:126480556 T/C cg08799069 chr10:126477246 METTL10 -0.44 -10.02 -0.37 4.79e-22 Cocaine dependence; BRCA trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg11707556 chr5:10655725 ANKRD33B 0.4 8.83 0.33 1.02e-17 Coronary artery disease; BRCA cis rs35110281 0.667 rs4819286 chr21:45120121 G/A cg21573476 chr21:45109991 RRP1B -0.41 -11.3 -0.41 4.15e-27 Mean corpuscular volume; BRCA cis rs739401 0.611 rs2239899 chr11:3024624 A/G cg05729581 chr11:3078854 CARS 0.36 8.86 0.33 7.64e-18 Longevity; BRCA cis rs6429082 0.818 rs291391 chr1:235649955 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 14.17 0.49 7.96e-40 Adiposity; BRCA cis rs1109501 0.881 rs28566795 chr4:71343532 C/T cg22786090 chr4:71381880 NA 0.36 7.85 0.3 1.8e-14 Alcoholism (heaviness of drinking); BRCA cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg20818283 chr2:191399100 TMEM194B 0.38 8.94 0.33 4.06e-18 Pulse pressure; BRCA cis rs9287719 0.935 rs728283 chr2:10750090 C/T cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA trans rs6479891 1.000 rs9414793 chr10:65075109 G/A cg14819942 chr15:35414228 NA -0.34 -8.45 -0.32 2.02e-16 Arthritis (juvenile idiopathic); BRCA cis rs4302748 0.862 rs11981777 chr7:36184753 G/A cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg08067268 chr2:26466485 HADHB;HADHA -0.56 -10.1 -0.37 2.4e-22 Gut microbiome composition (summer); BRCA cis rs3770081 1.000 rs17027011 chr2:86406556 C/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.58 -8.04 -0.3 4.4e-15 Facial emotion recognition (sad faces); BRCA cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg13736514 chr6:26305472 NA -0.37 -12.07 -0.43 2.4e-30 Educational attainment; BRCA cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg06558623 chr16:89946397 TCF25 0.58 10.55 0.39 4.34e-24 Skin colour saturation; BRCA cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -16.11 -0.54 2.87e-49 Chronic sinus infection; BRCA trans rs7647973 0.667 rs11721148 chr3:49646669 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.95 -0.3 8.62e-15 Menarche (age at onset); BRCA cis rs250677 0.522 rs4705301 chr5:148354902 C/G cg18129178 chr5:148520854 ABLIM3 -0.55 -10.48 -0.38 7.77e-24 Breast cancer; BRCA cis rs9612 1.000 rs346545 chr19:44256386 T/C cg08581076 chr19:44259116 C19orf61 0.52 9.64 0.36 1.31e-20 Exhaled nitric oxide output; BRCA cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs6912958 0.712 rs2754260 chr6:88397666 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.4 -0.32 2.8e-16 Monocyte percentage of white cells; BRCA trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg15704280 chr7:45808275 SEPT13 -0.5 -9.53 -0.35 3.27e-20 Acute lymphoblastic leukemia (childhood); BRCA cis rs4920343 0.890 rs4920531 chr1:19095746 A/G cg19637330 chr1:19110922 NA -0.39 -7.95 -0.3 8.72e-15 Knee osteoarthritis; BRCA cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11890956 chr21:40555474 PSMG1 1.06 31.86 0.78 4.18e-134 Cognitive function; BRCA cis rs2276314 1.000 rs9304153 chr18:33562150 T/C cg19628046 chr18:33552617 C18orf21 0.56 11.04 0.4 4.47e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg23711669 chr6:146136114 FBXO30 0.72 14.83 0.51 5.9e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742234 1.000 rs1864395 chr10:43655697 G/A cg15436174 chr10:43711423 RASGEF1A -0.42 -9.01 -0.34 2.43e-18 Hirschsprung disease; BRCA cis rs853679 0.542 rs34131763 chr6:28075000 A/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.49e-15 Depression; BRCA cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg24642439 chr20:33292090 TP53INP2 0.53 11.48 0.41 7.58e-28 Glomerular filtration rate (creatinine); BRCA cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg07493874 chr5:1342172 CLPTM1L -0.52 -14.85 -0.51 4.34e-43 Lung cancer; BRCA cis rs10504229 1.000 rs67594249 chr8:58180521 T/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.28e-36 Developmental language disorder (linguistic errors); BRCA cis rs311392 0.966 rs454975 chr8:55087514 T/C cg11783602 chr8:55087084 NA -0.33 -9.59 -0.35 1.94e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs919433 1.000 rs6761919 chr2:198163328 A/G cg10820045 chr2:198174542 NA -0.42 -9.61 -0.36 1.6e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs60843830 0.661 rs6755432 chr2:106692 T/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.49 9.51 0.35 3.7799999999999997e-20 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1707322 0.752 rs28545085 chr1:46201950 G/A cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg16339924 chr4:17578868 LAP3 -0.53 -12.7 -0.45 4.26e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg26597838 chr10:835615 NA 1.29 21.57 0.65 6.19e-78 Eosinophil percentage of granulocytes; BRCA cis rs7975161 0.521 rs4447242 chr12:104720708 T/G cg25273343 chr12:104657179 TXNRD1 -0.56 -8.98 -0.33 2.92e-18 Toenail selenium levels; BRCA cis rs2777491 0.574 rs316616 chr15:41746276 G/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -27.53 -0.74 1.32e-110 Ulcerative colitis; BRCA cis rs72781680 0.611 rs7596820 chr2:24335036 G/C cg06627628 chr2:24431161 ITSN2 -0.5 -8.26 -0.31 8.39e-16 Lymphocyte counts; BRCA cis rs1499972 0.941 rs817507 chr3:117681065 A/C cg07612923 chr3:117604196 NA -0.6 -8.19 -0.31 1.48e-15 Schizophrenia; BRCA cis rs9790314 0.875 rs55688744 chr3:160944222 G/A cg04691961 chr3:161091175 C3orf57 -0.41 -10.07 -0.37 3.14e-22 Morning vs. evening chronotype; BRCA cis rs10791323 0.569 rs10750542 chr11:133713436 T/C cg15485101 chr11:133734466 NA 0.39 9.6 0.36 1.78e-20 Childhood ear infection; BRCA cis rs2742417 0.603 rs2742457 chr3:45767487 G/A cg04837898 chr3:45731254 SACM1L -0.41 -8.14 -0.31 2e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg01262667 chr19:19385393 TM6SF2 -0.41 -10.74 -0.39 7.55e-25 Tonsillectomy; BRCA cis rs6831352 1.000 rs6837685 chr4:100049145 G/A cg12011299 chr4:100065546 ADH4 0.53 12.95 0.46 3.03e-34 Alcohol dependence; BRCA cis rs16976116 0.851 rs13380400 chr15:55490518 A/G cg11288833 chr15:55489084 RSL24D1 0.47 10.58 0.39 3.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8030485 0.716 rs12899109 chr15:79410970 T/C cg17916960 chr15:79447300 NA 0.34 7.9 0.3 1.27e-14 Left ventricle wall thickness; BRCA cis rs6088580 0.634 rs6087579 chr20:32985155 A/G cg24642439 chr20:33292090 TP53INP2 -0.54 -11.67 -0.42 1.16e-28 Glomerular filtration rate (creatinine); BRCA cis rs10129255 0.518 rs2006284 chr14:107132201 G/A cg07958169 chr14:107095056 NA -0.38 -8.14 -0.31 2.09e-15 Kawasaki disease; BRCA cis rs6815814 0.904 rs73236629 chr4:38825449 G/T cg02016764 chr4:38805732 TLR1 -0.54 -8.08 -0.3 3.26e-15 Breast cancer; BRCA cis rs3781663 0.500 rs10160730 chr11:70021687 T/C cg06393558 chr11:69982916 ANO1 -0.39 -8.96 -0.33 3.55e-18 Survival in rectal cancer; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.53 -0.32 1.09e-16 Gut microbiome composition (summer); BRCA cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg20891558 chr2:74357851 NA 0.57 11.88 0.43 1.51e-29 Gestational age at birth (maternal effect); BRCA cis rs4805272 0.512 rs765484 chr19:29344663 A/G cg12756686 chr19:29218302 NA 0.46 8.1 0.31 2.77e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7666738 0.791 rs60028147 chr4:99046618 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.63 0.55 7.2e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.21 0.37 9.15e-23 Aortic root size; BRCA cis rs3796352 1.000 rs13058817 chr3:53024139 C/T cg07884673 chr3:53033167 SFMBT1 0.86 9.98 0.37 6.83e-22 Immune reponse to smallpox (secreted IL-2); BRCA cis rs2839186 0.508 rs6518278 chr21:47640571 A/G cg12516959 chr21:47718080 NA 0.41 9.37 0.35 1.21e-19 Testicular germ cell tumor; BRCA cis rs4595586 0.655 rs7958206 chr12:39329294 G/A cg26384229 chr12:38710491 ALG10B 0.39 8.75 0.33 1.91e-17 Morning vs. evening chronotype; BRCA cis rs7772486 0.790 rs3924498 chr6:146233338 A/T cg23711669 chr6:146136114 FBXO30 -0.77 -17.92 -0.58 1.72e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.932 rs6132848 chr20:25561645 C/T cg08601574 chr20:25228251 PYGB 0.36 8.43 0.32 2.22e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4728302 0.838 rs755664 chr7:133596671 C/G cg07491979 chr7:133331646 EXOC4 0.36 7.83 0.3 1.99e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg14440974 chr22:39074834 NA 0.35 8.38 0.31 3.5e-16 Menopause (age at onset); BRCA cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg15605315 chr1:45957053 TESK2 0.49 10.16 0.37 1.45e-22 High light scatter reticulocyte count; BRCA cis rs11105298 0.891 rs10858903 chr12:89927972 G/A cg00757033 chr12:89920650 WDR51B 0.54 11.01 0.4 6.42e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs35306767 0.953 rs11253521 chr10:976416 G/C cg26597838 chr10:835615 NA 0.81 14.74 0.5 1.52e-42 Eosinophil percentage of granulocytes; BRCA cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.48 0.44 4.02e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3820928 0.874 rs13419455 chr2:227850465 C/G cg11843606 chr2:227700838 RHBDD1 -0.39 -8.59 -0.32 6.69e-17 Pulmonary function; BRCA cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg23442198 chr4:187126114 CYP4V2 0.83 9.68 0.36 8.88e-21 Activated partial thromboplastin time; BRCA trans rs61931739 0.517 rs11053224 chr12:34484919 G/A cg26384229 chr12:38710491 ALG10B 0.72 16.37 0.54 1.53e-50 Morning vs. evening chronotype; BRCA cis rs9296092 0.500 rs4376348 chr6:33521097 A/G cg13560919 chr6:33536144 NA -0.85 -17.72 -0.57 1.88e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg21475434 chr5:93447410 FAM172A 0.65 8.65 0.32 4e-17 Diabetic retinopathy; BRCA cis rs26868 0.742 rs26848 chr16:2263516 A/G cg25665528 chr16:2260870 C16orf79 -0.36 -9.14 -0.34 8.03e-19 Height; BRCA cis rs1878931 0.582 rs27231 chr16:3434966 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.55 9.62 0.36 1.51e-20 Body mass index (adult); BRCA cis rs2836950 0.805 rs2836961 chr21:40627020 A/C cg11644478 chr21:40555479 PSMG1 -0.42 -8.4 -0.32 2.83e-16 Menarche (age at onset); BRCA cis rs795484 0.610 rs2936839 chr12:118580315 T/C cg16572268 chr12:118583242 PEBP1 -0.36 -9.32 -0.35 1.88e-19 Morphine dose requirement in tonsillectomy and adenoidectomy surgery; BRCA cis rs7582180 0.563 rs4851304 chr2:100963871 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.9 -0.3 1.19e-14 Intelligence (multi-trait analysis); BRCA cis rs1595825 0.786 rs77218291 chr2:198565011 A/G cg19156104 chr2:198669113 PLCL1 -0.46 -8.38 -0.31 3.45e-16 Ulcerative colitis; BRCA cis rs6745190 0.575 rs7566146 chr2:181974086 T/C cg00481216 chr2:181971175 NA 0.4 9.43 0.35 7.52e-20 White blood cell count; BRCA cis rs910316 0.967 rs35446981 chr14:75637351 A/T cg11812906 chr14:75593930 NEK9 -0.63 -14.31 -0.49 1.64e-40 Height; BRCA cis rs12545109 0.643 rs1119707 chr8:57411548 T/C cg09654669 chr8:57350985 NA -0.41 -7.94 -0.3 9.17e-15 Obesity-related traits; BRCA cis rs7666738 0.830 rs11723283 chr4:99001617 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9811920 0.715 rs6776886 chr3:99906270 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.39 9.06 0.34 1.57e-18 Axial length; BRCA cis rs7520050 0.807 rs28378621 chr1:46189554 T/C cg24296786 chr1:45957014 TESK2 -0.47 -10.72 -0.39 8.89e-25 Red blood cell count;Reticulocyte count; BRCA cis rs61931739 0.500 rs2389269 chr12:34034179 C/T cg06521331 chr12:34319734 NA -0.62 -11.19 -0.4 1.1e-26 Morning vs. evening chronotype; BRCA cis rs561341 0.654 rs6505265 chr17:30172580 C/T cg23018236 chr17:30244563 NA 0.55 8.28 0.31 7.06e-16 Hip circumference adjusted for BMI; BRCA cis rs7975161 0.580 rs4246270 chr12:104728530 G/A cg25273343 chr12:104657179 TXNRD1 -0.56 -8.98 -0.33 2.92e-18 Toenail selenium levels; BRCA trans rs2204008 0.805 rs3863360 chr12:37966432 C/T cg06521331 chr12:34319734 NA -0.53 -10.19 -0.37 1.08e-22 Bladder cancer; BRCA cis rs12048904 0.619 rs12239082 chr1:101330077 G/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.52 -11.6 -0.42 2.35e-28 Multiple sclerosis; BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.23 0.34 3.82e-19 Tonsillectomy; BRCA cis rs4363385 0.791 rs489323 chr1:153006047 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs2243480 1.000 rs1796228 chr7:66033084 G/A cg18252515 chr7:66147081 NA -1.06 -15.83 -0.53 7.57e-48 Diabetic kidney disease; BRCA trans rs10506458 0.915 rs79133015 chr12:63396838 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -20.55 -0.63 1.94e-72 Hemostatic factors and hematological phenotypes; BRCA cis rs312273 0.582 rs312279 chr12:41256200 T/C cg17827154 chr12:41323612 CNTN1 -0.34 -8.06 -0.3 3.69e-15 Bipolar disorder; BRCA cis rs3818285 0.544 rs7899805 chr10:111671177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.36 -9.72 -0.36 6.27e-21 Superior crus of antihelix expression; BRCA cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg15017067 chr4:17643749 FAM184B 0.31 9.45 0.35 6.05e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4481887 0.893 rs4275482 chr1:248473506 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.76 0.33 1.69e-17 Common traits (Other); BRCA cis rs11718455 0.960 rs3843373 chr3:44011053 C/T cg08738300 chr3:44038990 NA -0.45 -8.56 -0.32 8.63e-17 Coronary artery disease; BRCA cis rs34779708 0.897 rs4934716 chr10:35369299 A/G cg03585969 chr10:35415529 CREM 0.49 10.29 0.38 4.56e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs8014204 0.762 rs12891131 chr14:75240090 A/G cg06637938 chr14:75390232 RPS6KL1 0.42 8.69 0.33 2.99e-17 Caffeine consumption; BRCA cis rs2404618 0.534 rs2214861 chr8:1490604 A/G cg13402656 chr8:1511478 DLGAP2 -0.58 -14.92 -0.51 1.96e-43 Lung cancer; BRCA trans rs2797160 0.935 rs1739372 chr6:126011325 G/A cg05039488 chr6:79577232 IRAK1BP1 0.36 7.98 0.3 6.72e-15 Endometrial cancer; BRCA cis rs992157 0.835 rs13005100 chr2:219151767 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.36 -0.41 2.36e-27 Colorectal cancer; BRCA cis rs6815814 0.898 rs5743562 chr4:38806096 T/C cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs875971 0.660 rs801193 chr7:66030612 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.34 -0.31 4.74e-16 Aortic root size; BRCA cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.1 0.4 2.73e-26 Bipolar disorder; BRCA cis rs881375 0.967 rs758959 chr9:123676699 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.8 0.39 4.51e-25 Rheumatoid arthritis; BRCA cis rs12500482 0.935 rs2239736 chr4:2438929 T/C cg26605046 chr4:2439731 NA -0.44 -10.15 -0.37 1.48e-22 Cognitive function; BRCA trans rs11039798 0.844 rs7126949 chr11:48972166 A/G cg15704280 chr7:45808275 SEPT13 0.6 8.93 0.33 4.6e-18 Axial length; BRCA cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg25767906 chr1:53392781 SCP2 -0.47 -10.34 -0.38 2.85e-23 Monocyte count; BRCA cis rs2479724 0.840 rs6925777 chr6:41750822 C/T cg17623882 chr6:41773611 USP49 0.37 10.12 0.37 2.03e-22 Menarche (age at onset); BRCA cis rs61931739 0.500 rs6488222 chr12:34526289 G/A cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA trans rs11098499 0.909 rs35165976 chr4:120325630 G/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.92 -0.3 1.02e-14 Corneal astigmatism; BRCA cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs9393692 0.645 rs4145910 chr6:26313305 T/C cg00631329 chr6:26305371 NA -0.55 -15.55 -0.52 1.68e-46 Educational attainment; BRCA cis rs2652834 1.000 rs68088462 chr15:63397617 T/C cg05507819 chr15:63340323 TPM1 0.45 8.06 0.3 3.77e-15 HDL cholesterol; BRCA trans rs7241530 0.623 rs2411417 chr18:75917469 G/A cg25697769 chr22:39097335 JOSD1 0.37 8.06 0.3 3.78e-15 Educational attainment (years of education); BRCA cis rs312273 0.685 rs391052 chr12:41378240 G/A cg17827154 chr12:41323612 CNTN1 -0.39 -10.2 -0.37 1.01e-22 Bipolar disorder; BRCA cis rs801193 0.569 rs2013908 chr7:66121069 A/T cg11764359 chr7:65958608 NA -0.73 -16.04 -0.54 6.41e-49 Aortic root size; BRCA cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg26149184 chr10:133730230 NA 0.4 8.2 0.31 1.37e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg14004847 chr7:1930337 MAD1L1 -0.47 -9.63 -0.36 1.36e-20 Bipolar disorder and schizophrenia; BRCA trans rs1493916 0.905 rs34165207 chr18:31400153 G/A cg27147174 chr7:100797783 AP1S1 -0.53 -10.37 -0.38 2.13e-23 Life satisfaction; BRCA cis rs10540 0.908 rs1044707 chr11:491334 G/T cg15790184 chr11:494944 RNH1 -0.66 -10.26 -0.38 5.73e-23 Body mass index; BRCA cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg11764359 chr7:65958608 NA -0.62 -13.35 -0.47 4.8e-36 Aortic root size; BRCA cis rs853679 0.517 rs4713144 chr6:28106790 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.14 -0.31 2.1e-15 Depression; BRCA cis rs7246657 0.943 rs7255407 chr19:37933936 G/A cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA cis rs9790314 0.747 rs4616689 chr3:160856269 A/G cg04691961 chr3:161091175 C3orf57 -0.46 -9.94 -0.37 9.5e-22 Morning vs. evening chronotype; BRCA trans rs1493916 0.748 rs1845386 chr18:31318256 C/G cg15819921 chr19:927150 ARID3A -0.44 -8.23 -0.31 1.02e-15 Life satisfaction; BRCA cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg03477792 chr4:77819574 ANKRD56 0.62 15.03 0.51 5.77e-44 Emphysema distribution in smoking; BRCA trans rs2739330 0.734 rs2000467 chr22:24241533 C/T cg06437703 chr8:37914619 EIF4EBP1 0.31 7.88 0.3 1.44e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs870825 0.616 rs28608669 chr4:185632890 T/C cg04058563 chr4:185651563 MLF1IP 0.76 16.91 0.56 2.63e-53 Blood protein levels; BRCA cis rs4588572 0.643 rs10044028 chr5:77794750 C/T cg11547950 chr5:77652471 NA 0.5 9.15 0.34 7.51e-19 Triglycerides; BRCA cis rs6840360 0.550 rs4696269 chr4:152481704 T/A cg22705602 chr4:152727874 NA -0.32 -8.06 -0.3 3.75e-15 Intelligence (multi-trait analysis); BRCA cis rs965469 0.779 rs6139071 chr20:3299054 A/G cg25506879 chr20:3388711 C20orf194 -0.46 -9.19 -0.34 5.58e-19 IFN-related cytopenia; BRCA cis rs853679 0.517 rs6941992 chr6:28106141 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.14 -0.31 2.1e-15 Depression; BRCA cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg27015174 chr15:43622946 ADAL;LCMT2 -0.42 -8.52 -0.32 1.18e-16 Lung cancer in ever smokers; BRCA cis rs3767633 0.925 rs4656339 chr1:161915387 A/T cg09175582 chr1:161736000 ATF6 0.5 8.69 0.32 3.15e-17 IgG glycosylation; BRCA cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg16339924 chr4:17578868 LAP3 0.56 13.9 0.48 1.42e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2386661 0.516 rs61832676 chr10:5646337 G/A cg17085576 chr10:5658249 NA -0.33 -8.1 -0.31 2.83e-15 Breast cancer; BRCA cis rs7618915 0.547 rs33967311 chr3:52683864 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.08 0.37 2.74e-22 Bipolar disorder; BRCA cis rs6964587 1.000 rs2282972 chr7:91666369 C/T cg01689657 chr7:91764605 CYP51A1 0.23 8.36 0.31 3.95e-16 Breast cancer; BRCA cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg18876405 chr7:65276391 NA 0.71 18.71 0.59 1.32e-62 Calcium levels; BRCA cis rs11190604 1.000 rs4917901 chr10:102201773 A/C cg07080220 chr10:102295463 HIF1AN 0.49 11.32 0.41 3.25e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs17253792 0.822 rs8018142 chr14:56173288 C/T cg01858014 chr14:56050164 KTN1 -0.57 -8.93 -0.33 4.51e-18 Putamen volume; BRCA cis rs79390637 1 rs79390637 chr11:47456867 C/A cg20307385 chr11:47447363 PSMC3 0.51 11.55 0.42 3.81e-28 Intraocular pressure; BRCA cis rs503734 0.502 rs348885 chr3:100976219 C/G cg27318481 chr3:100970896 IMPG2 -0.41 -9.82 -0.36 2.65e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs812925 0.502 rs778150 chr2:61608372 C/T cg15711740 chr2:61764176 XPO1 0.32 7.86 0.3 1.64e-14 Immature fraction of reticulocytes; BRCA trans rs9650657 0.771 rs6601513 chr8:10594843 A/G cg06636001 chr8:8085503 FLJ10661 -0.39 -8.1 -0.31 2.77e-15 Neuroticism; BRCA trans rs1200821 0.535 rs1938417 chr10:37687520 A/C cg25427524 chr10:38739819 LOC399744 0.39 8.27 0.31 7.61e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs9811920 0.638 rs7629426 chr3:99652577 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -16.08 -0.54 3.95e-49 Axial length; BRCA cis rs1153858 1.000 rs2056493 chr15:45648272 A/G cg14582100 chr15:45693742 SPATA5L1 0.34 10.15 0.37 1.55e-22 Homoarginine levels; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg02353165 chr6:42928485 GNMT 0.89 24.06 0.69 1.53e-91 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs698813 0.604 rs4953077 chr2:44481207 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.44 7.91 0.3 1.15e-14 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs2304069 0.614 rs216140 chr5:149443298 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.35 8.54 0.32 9.57e-17 HIV-1 control; BRCA cis rs710216 0.536 rs710221 chr1:43414200 G/A cg03128534 chr1:43423976 SLC2A1 0.62 15.04 0.51 5.73e-44 Red cell distribution width; BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.08 0.34 1.39e-18 Tonsillectomy; BRCA cis rs12760731 0.720 rs10913557 chr1:178442190 C/T cg00404053 chr1:178313656 RASAL2 0.61 7.96 0.3 8.08e-15 Obesity-related traits; BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -9.82 -0.36 2.6e-21 Gut microbiome composition (summer); BRCA cis rs7927771 0.524 rs10838769 chr11:47825333 A/G cg20307385 chr11:47447363 PSMC3 -0.4 -9.5 -0.35 4.09e-20 Subjective well-being; BRCA cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg07917127 chr4:99064746 C4orf37 0.41 7.85 0.3 1.7e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg13647721 chr17:30228624 UTP6 0.5 8.7 0.33 2.89e-17 Hip circumference adjusted for BMI; BRCA cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg12311346 chr5:56204834 C5orf35 -0.77 -15.54 -0.52 2.06e-46 Initial pursuit acceleration; BRCA cis rs490234 0.805 rs562004 chr9:128321771 T/C cg14078157 chr9:128172775 NA 0.34 7.98 0.3 6.71e-15 Mean arterial pressure; BRCA trans rs7939886 0.920 rs10501343 chr11:55759573 G/T cg15704280 chr7:45808275 SEPT13 0.62 7.94 0.3 9.08e-15 Myopia (pathological); BRCA cis rs9393777 0.513 rs926300 chr6:27059443 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.31 -8.21 -0.31 1.25e-15 Intelligence (multi-trait analysis); BRCA cis rs4727027 1.000 rs4727027 chr7:148869277 C/T cg23583168 chr7:148888333 NA -0.88 -20.81 -0.64 7.98e-74 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7523273 0.606 rs10449303 chr1:207961058 A/G cg22525895 chr1:207977042 MIR29B2 -0.53 -13.42 -0.47 2.28e-36 Schizophrenia; BRCA cis rs7572263 0.724 rs34082227 chr2:209055449 G/T cg23998903 chr2:209048830 C2orf80 -0.42 -8.55 -0.32 9.21e-17 Glioma;Non-glioblastoma glioma; BRCA cis rs3760982 0.585 rs68073292 chr19:44291401 T/C cg12072164 chr19:44306565 LYPD5 0.37 8.67 0.32 3.5e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg26314531 chr2:26401878 FAM59B 0.94 16.39 0.54 1.24e-50 Gut microbiome composition (summer); BRCA cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg06552810 chr11:31128660 NA -0.39 -8.69 -0.33 3.06e-17 Red blood cell count; BRCA cis rs36051895 0.559 rs72701682 chr9:5208025 A/G cg02405213 chr9:5042618 JAK2 -0.46 -8.18 -0.31 1.58e-15 Pediatric autoimmune diseases; BRCA cis rs9649465 0.522 rs662705 chr7:123431594 A/C cg03229431 chr7:123269106 ASB15 0.41 9.35 0.35 1.4e-19 Migraine; BRCA cis rs6867032 1.000 rs6867032 chr5:2015103 G/T cg26168224 chr5:2018326 NA -0.63 -17.86 -0.58 3.39e-58 Gut microbiome composition (winter); BRCA cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.72 0.71 1.05e-100 Chronic sinus infection; BRCA cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg19717773 chr7:2847554 GNA12 -0.46 -9.84 -0.36 2.19e-21 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg12444411 chr7:2802554 GNA12 -0.38 -9.35 -0.35 1.47e-19 Height; BRCA cis rs2153535 0.580 rs6597326 chr6:8482019 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.55 0.39 4.3e-24 Motion sickness; BRCA cis rs9329289 0.851 rs61835719 chr10:2543390 A/G cg15501526 chr10:2543763 NA 0.58 14.06 0.49 2.46e-39 Age-related hearing impairment; BRCA cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg24977027 chr2:88469347 THNSL2 0.56 9.44 0.35 6.66e-20 Plasma clusterin levels; BRCA cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg03433033 chr1:76189801 ACADM 0.76 17.39 0.57 9.72e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg00166722 chr3:10149974 C3orf24 0.65 12.75 0.45 2.35e-33 Alzheimer's disease; BRCA cis rs9341808 0.754 rs3812126 chr6:80952701 A/G cg08355045 chr6:80787529 NA -0.38 -9.96 -0.37 8.06e-22 Sitting height ratio; BRCA cis rs7577696 0.554 rs35978916 chr2:32400635 T/C cg02381751 chr2:32503542 YIPF4 -0.48 -8.79 -0.33 1.34e-17 Inflammatory biomarkers; BRCA cis rs796364 0.951 rs7586320 chr2:201068209 C/G cg23649088 chr2:200775458 C2orf69 0.61 10.58 0.39 3.19e-24 Schizophrenia; BRCA cis rs13161895 1.000 rs4389651 chr5:179460968 T/A cg02702477 chr5:179499311 RNF130 0.45 8.45 0.32 2.01e-16 LDL cholesterol; BRCA cis rs34779708 0.931 rs11010101 chr10:35411045 T/A cg03585969 chr10:35415529 CREM 0.5 10.46 0.38 9.82e-24 Inflammatory bowel disease;Crohn's disease; BRCA cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg01849466 chr14:104193079 ZFYVE21 -0.42 -10.68 -0.39 1.34e-24 Schizophrenia; BRCA cis rs6087771 0.851 rs6087775 chr20:30325765 G/A cg13852791 chr20:30311386 BCL2L1 0.84 18.23 0.58 4.23e-60 Subcortical brain region volumes;Putamen volume; BRCA trans rs3733585 0.673 rs4459990 chr4:9954005 T/C cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 8.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10463316 0.823 rs7700340 chr5:150776320 C/T cg03212797 chr5:150827313 SLC36A1 -0.42 -8.18 -0.31 1.54e-15 Metabolite levels (Pyroglutamine); BRCA cis rs3617 0.539 rs9985365 chr3:52953844 A/G cg11645453 chr3:52864694 ITIH4 -0.37 -9.78 -0.36 3.69e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs477895 0.838 rs12794145 chr11:64006484 C/T cg23719950 chr11:63933701 MACROD1 -0.53 -8.53 -0.32 1.08e-16 Mean platelet volume; BRCA cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.37 8.0 0.3 5.67e-15 Platelet count; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg18402987 chr7:1209562 NA 0.51 9.49 0.35 4.43e-20 Longevity;Endometriosis; BRCA cis rs11098499 0.909 rs10020034 chr4:120294331 A/G cg09307838 chr4:120376055 NA 0.73 15.6 0.53 9.59e-47 Corneal astigmatism; BRCA cis rs11971779 0.838 rs11764161 chr7:139115198 T/C cg07862535 chr7:139043722 LUC7L2 0.44 11.35 0.41 2.6e-27 Diisocyanate-induced asthma; BRCA trans rs561341 1.000 rs561341 chr17:30316385 T/G cg20587970 chr11:113659929 NA -1.21 -22.23 -0.66 1.6e-81 Hip circumference adjusted for BMI; BRCA cis rs9868809 0.505 rs13316551 chr3:48745167 A/C cg01304814 chr3:48885189 PRKAR2A 0.57 8.01 0.3 5.25e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.5 -0.38 6.85e-24 Personality dimensions; BRCA cis rs1865760 0.593 rs2097273 chr6:25941310 A/C cg12310025 chr6:25882481 NA -0.37 -8.64 -0.32 4.38e-17 Height; BRCA cis rs67460515 0.563 rs13071892 chr3:160817877 A/C cg03342759 chr3:160939853 NMD3 -0.71 -14.55 -0.5 1.21e-41 Parkinson's disease; BRCA cis rs2749592 0.550 rs4934881 chr10:37914346 A/C cg25427524 chr10:38739819 LOC399744 0.58 13.28 0.47 9.93e-36 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg04450456 chr4:17643702 FAM184B 0.39 11.62 0.42 1.95e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.34 0.75 4.7e-115 Chronic sinus infection; BRCA cis rs8064299 0.967 rs7420 chr17:72765215 A/G cg25054828 chr17:72772726 NAT9;TMEM104 -0.39 -11.13 -0.4 2.04e-26 Monocyte count; BRCA cis rs2629540 0.847 rs12247543 chr10:126419743 G/C cg08799069 chr10:126477246 METTL10 0.44 8.98 0.33 2.97e-18 Cocaine dependence; BRCA cis rs6087990 1.000 rs6087990 chr20:31349908 T/C cg13636640 chr20:31349939 DNMT3B 0.8 27.46 0.74 3.23e-110 Ulcerative colitis; BRCA cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.92 0.4 1.43e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1003719 0.788 rs1155787 chr21:38448069 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.26e-40 Eye color traits; BRCA cis rs2282802 0.685 rs2436391 chr5:139557385 C/T cg26211634 chr5:139558579 C5orf32 -0.33 -7.98 -0.3 6.85e-15 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.697 rs6088857 chr20:30226764 G/C cg21427119 chr20:30132790 HM13 -0.43 -9.04 -0.34 1.81e-18 Mean corpuscular hemoglobin; BRCA cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg17971929 chr21:40555470 PSMG1 -0.45 -9.27 -0.34 2.88e-19 Menarche (age at onset); BRCA cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs12210905 0.688 rs12195783 chr6:27444345 A/G cg08851530 chr6:28072375 NA 0.78 7.84 0.3 1.88e-14 Hip circumference adjusted for BMI; BRCA cis rs1691799 0.867 rs2172881 chr12:66766039 C/G cg16791601 chr12:66731901 HELB -0.63 -16.97 -0.56 1.41e-53 White blood cell count (basophil); BRCA cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg07520158 chr7:32535189 LSM5;AVL9 -0.46 -9.88 -0.36 1.6e-21 Cognitive ability; BRCA cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg11663144 chr21:46675770 NA -0.59 -13.74 -0.48 8.29e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg14061069 chr19:46274453 DMPK -0.41 -9.46 -0.35 5.86e-20 Coronary artery disease; BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg03354898 chr7:1950403 MAD1L1 -0.49 -10.17 -0.37 1.26e-22 Bipolar disorder and schizophrenia; BRCA cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.59 -12.45 -0.44 5.12e-32 Personality dimensions; BRCA trans rs7618501 0.735 rs9876508 chr3:49780844 G/A cg21659725 chr3:3221576 CRBN -0.71 -21.71 -0.65 1.04e-78 Intelligence (multi-trait analysis); BRCA cis rs4268898 1.000 rs2303294 chr2:24432620 A/G cg06627628 chr2:24431161 ITSN2 0.5 10.44 0.38 1.14e-23 Asthma; BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg08280861 chr8:58055591 NA 0.53 8.68 0.32 3.27e-17 Developmental language disorder (linguistic errors); BRCA cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg15997130 chr1:24165203 NA 0.49 13.34 0.47 5.3e-36 Immature fraction of reticulocytes; BRCA trans rs783540 0.542 rs62009945 chr15:83299956 T/A cg16105309 chr15:79090380 ADAMTS7 0.34 8.56 0.32 8.65e-17 Schizophrenia; BRCA cis rs17253792 0.822 rs77182097 chr14:56136695 G/A cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs887829 0.569 rs2008595 chr2:234637192 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.35 -0.31 4.3e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs6460942 0.915 rs62447640 chr7:12488282 A/T cg06484146 chr7:12443880 VWDE -0.76 -10.67 -0.39 1.43e-24 Coronary artery disease; BRCA cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg23033748 chr14:75592666 NEK9 0.43 10.25 0.38 6.35e-23 Height; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs4319547 0.626 rs12423420 chr12:122938466 G/A cg23029597 chr12:123009494 RSRC2 -0.46 -9.32 -0.35 1.84e-19 Body mass index; BRCA trans rs11976180 1.000 rs2961117 chr7:143755253 C/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.43 -7.87 -0.3 1.49e-14 Obesity-related traits; BRCA cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs10924970 0.967 rs2382616 chr1:235454237 C/T cg26050004 chr1:235667680 B3GALNT2 0.35 8.55 0.32 9.19e-17 Asthma; BRCA cis rs2180341 1.000 rs9285460 chr6:127640190 A/G cg24812749 chr6:127587940 RNF146 0.88 20.75 0.63 1.58e-73 Breast cancer; BRCA cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg06627628 chr2:24431161 ITSN2 0.56 8.95 0.33 3.81e-18 Lymphocyte counts; BRCA cis rs3771570 1.000 rs6752050 chr2:242228780 T/C cg21155796 chr2:242212141 HDLBP 0.58 8.85 0.33 8.46e-18 Prostate cancer; BRCA cis rs4908768 0.501 rs11121201 chr1:8632791 A/T cg20416874 chr1:8611966 RERE -0.28 -8.17 -0.31 1.65e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs4481887 0.962 rs6663952 chr1:248465682 A/G cg00666640 chr1:248458726 OR2T12 0.33 8.93 0.33 4.51e-18 Common traits (Other); BRCA trans rs6582630 0.519 rs11495373 chr12:38275470 T/C cg06521331 chr12:34319734 NA -0.49 -9.03 -0.34 2.06e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs6701037 0.681 rs1057239 chr1:175130204 G/A cg00321850 chr1:175162397 KIAA0040 -0.41 -11.19 -0.4 1.17e-26 Alcohol dependence; BRCA cis rs66569888 0.789 rs17213510 chr2:106742778 T/C cg16099169 chr2:106886729 NA -0.59 -9.98 -0.37 6.66e-22 Facial morphology (factor 23); BRCA cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg27398817 chr8:82754497 SNX16 0.37 8.54 0.32 1e-16 Diastolic blood pressure; BRCA cis rs7309 0.935 rs10930013 chr2:162070325 G/A cg22496339 chr2:162101262 NA 0.58 13.04 0.46 1.21e-34 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs12949688 0.967 rs8081251 chr17:55824033 A/G cg12582317 chr17:55822272 NA 0.32 7.95 0.3 8.73e-15 Schizophrenia; BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg26119090 chr2:26468346 HADHA;HADHB 0.81 14.49 0.5 2.43e-41 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.83e-24 Motion sickness; BRCA cis rs9473147 0.516 rs1485780 chr6:47556630 A/C cg12968598 chr6:47444699 CD2AP 0.44 9.62 0.36 1.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs861020 0.677 rs2049998 chr1:210031154 C/T cg09163369 chr1:210001066 C1orf107 -0.59 -10.54 -0.38 4.57e-24 Orofacial clefts; BRCA cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA trans rs208520 0.739 rs1935894 chr6:66891434 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.93 -18.04 -0.58 4.06e-59 Exhaled nitric oxide output; BRCA cis rs7568498 0.564 rs10490563 chr2:161914168 G/A cg21518248 chr2:162101506 NA -0.47 -9.09 -0.34 1.21e-18 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); BRCA cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg18876405 chr7:65276391 NA 0.55 12.5 0.44 3.25e-32 Calcium levels; BRCA cis rs1348850 0.874 rs4893822 chr2:178285727 G/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.44 8.66 0.32 3.85e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7666738 0.830 rs13125537 chr4:98978428 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.95 0.56 1.76e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg05754148 chr16:3507555 NAT15 0.53 7.9 0.3 1.23e-14 Tuberculosis; BRCA cis rs708547 0.874 rs1614251 chr4:57891386 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -9.85 -0.36 2.07e-21 Response to bleomycin (chromatid breaks); BRCA cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg12310025 chr6:25882481 NA 0.71 17.27 0.56 4.13e-55 Blood metabolite levels; BRCA cis rs8072100 0.967 rs11871606 chr17:45732774 G/T cg25173405 chr17:45401733 C17orf57 0.48 10.29 0.38 4.57e-23 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 14.78 0.5 9.58e-43 Platelet count; BRCA trans rs7824557 0.767 rs2164272 chr8:11162496 A/C cg08975724 chr8:8085496 FLJ10661 0.43 7.95 0.3 8.66e-15 Retinal vascular caliber; BRCA cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg26116260 chr4:7069785 GRPEL1 0.95 27.92 0.74 9.28e-113 Monocyte percentage of white cells; BRCA cis rs1059312 0.545 rs12303387 chr12:129276733 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 0.48 9.71 0.36 7.14e-21 Systemic lupus erythematosus; BRCA cis rs1355223 0.506 rs7130678 chr11:34869181 A/G cg11058730 chr11:34937778 PDHX;APIP -0.5 -9.76 -0.36 4.49e-21 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7246657 0.882 rs10412043 chr19:37826626 A/C cg18154014 chr19:37997991 ZNF793 0.48 9.5 0.35 4.15e-20 Coronary artery calcification; BRCA cis rs7772486 0.790 rs2254283 chr6:146204289 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.12 0.31 2.44e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.875 rs9390377 chr6:146386932 G/A cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.18e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2842992 0.958 rs2758318 chr6:160069637 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.66 17.14 0.56 1.86e-54 Age-related macular degeneration (geographic atrophy); BRCA cis rs9399135 0.967 rs13191501 chr6:135366880 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.46e-31 Red blood cell count; BRCA cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg17509989 chr5:176798049 RGS14 0.64 12.74 0.45 2.72e-33 Hemoglobin concentration;Hematocrit; BRCA cis rs9653442 0.609 rs2576678 chr2:100704810 T/C cg07810366 chr2:100720526 AFF3 -0.3 -7.86 -0.3 1.64e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg03609598 chr5:56110824 MAP3K1 -0.47 -8.11 -0.31 2.54e-15 Initial pursuit acceleration; BRCA trans rs1493916 0.837 rs9945976 chr18:31409314 C/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.48 -0.32 1.55e-16 Life satisfaction; BRCA cis rs1577917 0.876 rs12190735 chr6:86686467 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.16 -0.4 1.51e-26 Response to antipsychotic treatment; BRCA cis rs61931739 0.534 rs4365131 chr12:34053308 T/C cg06521331 chr12:34319734 NA -0.63 -12.18 -0.43 7.88e-31 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.28 0.31 7.42e-16 Asthma; BRCA cis rs3008870 0.958 rs34367328 chr1:67445321 T/C cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs10751667 0.961 rs7395928 chr11:952605 T/G ch.11.42038R chr11:967971 AP2A2 0.58 19.0 0.6 3.69e-64 Alzheimer's disease (late onset); BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg07308232 chr7:1071921 C7orf50 -0.51 -10.72 -0.39 9.32e-25 Longevity;Endometriosis; BRCA cis rs12022452 0.506 rs11208363 chr1:41010454 A/G cg25568243 chr1:40974465 DEM1 0.45 8.28 0.31 7.06e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg16339924 chr4:17578868 LAP3 0.62 15.36 0.52 1.59e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7772486 0.846 rs2492856 chr6:146323928 A/G cg23711669 chr6:146136114 FBXO30 0.65 14.73 0.5 1.63e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs6831352 0.918 rs2602896 chr4:100046207 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.69 -0.36 8.48e-21 Alcohol dependence; BRCA cis rs17270561 0.609 rs4711093 chr6:25687895 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.87 0.33 7.32e-18 Iron status biomarkers; BRCA cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg08822215 chr16:89438651 ANKRD11 0.45 9.66 0.36 1.06e-20 Multiple myeloma (IgH translocation); BRCA cis rs13108904 0.905 rs34490749 chr4:1217981 A/G cg05665937 chr4:1216051 CTBP1 0.52 10.85 0.39 2.76e-25 Obesity-related traits; BRCA cis rs9287719 0.614 rs12622053 chr2:10722140 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg04944784 chr2:26401820 FAM59B -0.64 -10.6 -0.39 2.66e-24 Gut microbiome composition (summer); BRCA cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg18357526 chr6:26021779 HIST1H4A 0.48 8.85 0.33 8.74e-18 Intelligence (multi-trait analysis); BRCA cis rs2011503 0.891 rs2965190 chr19:19451591 A/G cg15839431 chr19:19639596 YJEFN3 0.35 8.05 0.3 4.14e-15 Bipolar disorder; BRCA cis rs2404602 0.532 rs284892 chr15:76721037 A/G cg23625390 chr15:77176239 SCAPER 0.42 10.41 0.38 1.45e-23 Blood metabolite levels; BRCA cis rs243505 0.898 rs243540 chr7:148403312 A/G cg09806900 chr7:148480153 CUL1 -0.42 -8.33 -0.31 4.81e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs250677 0.522 rs10050928 chr5:148353463 C/A cg12140854 chr5:148520817 ABLIM3 0.41 8.24 0.31 9.66e-16 Breast cancer; BRCA cis rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05901451 chr6:126070800 HEY2 -0.55 -14.18 -0.49 7.14e-40 Brugada syndrome; BRCA cis rs17376456 1.000 rs13174700 chr5:93554644 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.55 0.32 9.24e-17 Diabetic retinopathy; BRCA cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg21280719 chr6:42927975 GNMT 0.26 8.56 0.32 8.23e-17 Blood protein levels; BRCA cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg13319975 chr6:146136371 FBXO30 -0.38 -8.62 -0.32 5.14e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs754466 1.000 rs754466 chr10:79680434 A/T cg17075019 chr10:79541650 NA -0.54 -11.06 -0.4 3.91e-26 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs11098499 0.657 rs4463052 chr4:120313258 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs10174077 0.874 rs10186656 chr2:152475938 T/G cg06191203 chr2:152266755 RIF1 -0.33 -9.44 -0.35 6.57e-20 Squamous cell lung carcinoma; BRCA cis rs911555 0.723 rs2273701 chr14:103923225 G/T cg24130564 chr14:104152367 KLC1 0.36 8.2 0.31 1.33e-15 Intelligence (multi-trait analysis); BRCA cis rs9403521 1.000 rs117303301 chr6:143999003 C/T cg18240653 chr6:144019428 PHACTR2 -0.41 -8.18 -0.31 1.5e-15 Obesity-related traits; BRCA cis rs7264396 0.635 rs6058351 chr20:34486093 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.92 -0.51 2.06e-43 Total cholesterol levels; BRCA cis rs4919087 0.962 rs10882889 chr10:99045890 A/G cg25902810 chr10:99078978 FRAT1 0.45 9.4 0.35 9.69e-20 Monocyte count; BRCA cis rs60871478 0.636 rs7792072 chr7:886239 C/T cg05535760 chr7:792225 HEATR2 -0.73 -11.6 -0.42 2.2e-28 Cerebrospinal P-tau181p levels; BRCA cis rs2011503 1.000 rs45556231 chr19:19654189 G/A cg11584989 chr19:19387371 SF4 0.62 12.97 0.46 2.52e-34 Bipolar disorder; BRCA trans rs11098499 0.863 rs3822190 chr4:120428098 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.12 0.31 2.33e-15 Corneal astigmatism; BRCA cis rs7640424 0.628 rs7628325 chr3:107816314 G/A cg09227934 chr3:107805635 CD47 -0.44 -8.22 -0.31 1.1e-15 Body mass index; BRCA cis rs7100689 0.542 rs10887869 chr10:82194689 A/G cg00277334 chr10:82204260 NA -0.58 -13.26 -0.46 1.31e-35 Post bronchodilator FEV1; BRCA trans rs3780486 0.846 rs10971420 chr9:33125000 T/C cg20290983 chr6:43655470 MRPS18A 1.12 41.98 0.86 7.04e-186 IgG glycosylation; BRCA cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.57 -0.61 3.59e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4535700 0.501 rs9642405 chr7:55978166 C/T cg09872392 chr7:56161020 PHKG1 0.35 8.07 0.3 3.51e-15 Macular telangiectasia type 2; BRCA cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 3.96e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12986413 1.000 rs12983458 chr19:2168612 A/G cg09261902 chr19:2140048 AP3D1 0.39 10.31 0.38 3.74e-23 Height; BRCA cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg11266682 chr4:10021025 SLC2A9 0.48 12.68 0.45 4.85e-33 Bone mineral density; BRCA cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.99 -0.3 6.24e-15 Bipolar disorder; BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg22920501 chr2:26401640 FAM59B 0.74 10.71 0.39 1.01e-24 Gut microbiome composition (summer); BRCA cis rs2806561 0.734 rs667211 chr1:23516142 T/C cg12483005 chr1:23474871 LUZP1 0.44 9.81 0.36 2.84e-21 Height; BRCA cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg02734326 chr4:10020555 SLC2A9 0.38 8.18 0.31 1.56e-15 Bone mineral density; BRCA cis rs6484504 0.532 rs2616799 chr11:31319044 T/C cg06552810 chr11:31128660 NA 0.4 8.89 0.33 6.19e-18 Red blood cell count; BRCA cis rs3733585 0.673 rs7376505 chr4:9952744 C/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.28 -0.38 5.01e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2836950 0.545 rs11700813 chr21:40517469 T/G cg11890956 chr21:40555474 PSMG1 -0.61 -13.47 -0.47 1.34e-36 Menarche (age at onset); BRCA cis rs4363385 0.818 rs557553 chr1:153010370 T/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.17 -0.34 6.49e-19 Inflammatory skin disease; BRCA cis rs7246657 0.653 rs4805208 chr19:37674259 G/A cg18154014 chr19:37997991 ZNF793 0.54 9.05 0.34 1.73e-18 Coronary artery calcification; BRCA cis rs6545883 0.826 rs777593 chr2:61419103 C/A cg15711740 chr2:61764176 XPO1 -0.53 -12.94 -0.46 3.57e-34 Tuberculosis; BRCA cis rs72781680 0.898 rs12622290 chr2:23979894 C/G cg20701182 chr2:24300061 SF3B14 0.56 8.61 0.32 5.89e-17 Lymphocyte counts; BRCA cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg07606381 chr6:8435919 SLC35B3 0.64 14.17 0.49 7.64e-40 Motion sickness; BRCA cis rs9611565 0.694 rs202617 chr22:41822793 C/T cg19274703 chr22:41806451 NA -0.37 -8.4 -0.32 2.99e-16 Vitiligo; BRCA cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg03264133 chr6:25882463 NA -0.51 -10.64 -0.39 1.86e-24 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.624 rs10172926 chr2:10733254 A/C cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs9868809 0.881 rs7620853 chr3:48666503 G/A cg00383909 chr3:49044727 WDR6 0.52 7.92 0.3 1.08e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7786877 0.723 rs62482239 chr7:100217810 C/T cg16850897 chr7:100343110 ZAN -0.57 -11.11 -0.4 2.51e-26 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs11711311 1.000 rs3732793 chr3:113442198 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.71 -0.36 6.84e-21 IgG glycosylation; BRCA cis rs9815354 0.812 rs113528686 chr3:41951547 T/C cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2904967 0.866 rs526502 chr11:65026590 T/C cg09225861 chr11:65069680 NA -0.39 -8.07 -0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs2625529 0.652 rs2957361 chr15:72345218 G/A cg16672083 chr15:72433130 SENP8 0.65 15.48 0.52 4.12e-46 Red blood cell count; BRCA cis rs10189230 0.967 rs12993766 chr2:222350321 C/T cg14652038 chr2:222343519 EPHA4 0.48 13.26 0.46 1.28e-35 Urate levels in lean individuals; BRCA cis rs7552404 1.000 rs4949674 chr1:76213715 C/A cg22875332 chr1:76189707 ACADM 0.7 14.97 0.51 1.26e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17376456 0.877 rs10070390 chr5:93452345 G/A cg21475434 chr5:93447410 FAM172A 0.68 9.2 0.34 5.14e-19 Diabetic retinopathy; BRCA cis rs7267979 0.966 rs2261790 chr20:25262789 T/C cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6964587 0.967 rs10429103 chr7:91598443 T/A cg01689657 chr7:91764605 CYP51A1 0.21 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg02675527 chr2:114030824 PAX8;LOC440839 -0.43 -9.97 -0.37 7.13e-22 Lymphocyte counts; BRCA cis rs1577917 0.958 rs12191340 chr6:86521400 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.94 -0.43 7.97e-30 Response to antipsychotic treatment; BRCA cis rs4319547 0.695 rs4758648 chr12:122900460 A/G cg05707623 chr12:122985044 ZCCHC8 -0.39 -8.19 -0.31 1.42e-15 Body mass index; BRCA cis rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05901451 chr6:126070800 HEY2 -0.55 -15.0 -0.51 8.26e-44 Brugada syndrome; BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.17 -0.43 8.62e-31 Alzheimer's disease; BRCA cis rs8054556 0.647 rs11863174 chr16:30019375 A/C cg06326092 chr16:30034487 C16orf92 0.31 7.98 0.3 6.58e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6484504 0.576 rs208066 chr11:31156206 C/G cg14844989 chr11:31128820 NA -0.43 -9.05 -0.34 1.7e-18 Red blood cell count; BRCA cis rs593982 0.843 rs680948 chr11:65472394 C/G cg08755490 chr11:65554678 OVOL1 1.14 16.68 0.55 4.1e-52 Atopic dermatitis; BRCA cis rs13046373 0.535 rs35909098 chr21:32021649 C/T cg22337977 chr21:31811175 KRTAP15-1 0.33 7.92 0.3 1.04e-14 HDL cholesterol; BRCA cis rs992157 0.835 rs6707559 chr2:219142773 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.52 11.16 0.4 1.5e-26 Colorectal cancer; BRCA cis rs534126 0.778 rs6464540 chr7:142954903 G/A cg22531018 chr7:142981779 TMEM139 0.48 10.82 0.39 3.44e-25 Cancer; BRCA cis rs921968 0.643 rs832801 chr2:219488698 G/A cg02176678 chr2:219576539 TTLL4 0.43 11.56 0.42 3.34e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs2153535 0.580 rs7743686 chr6:8526111 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.78 0.33 1.48e-17 Motion sickness; BRCA cis rs9470366 0.883 rs9462210 chr6:36628953 G/A cg08179530 chr6:36648295 CDKN1A 0.49 9.76 0.36 4.41e-21 QRS duration; BRCA cis rs12618769 0.652 rs76525766 chr2:99221088 A/G cg10123293 chr2:99228465 UNC50 0.42 8.49 0.32 1.44e-16 Bipolar disorder; BRCA cis rs7552404 0.883 rs2185436 chr1:76203783 A/G cg22875332 chr1:76189707 ACADM 0.81 19.69 0.61 7.96e-68 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10788264 0.518 rs1028632 chr10:124044657 C/G cg09507567 chr10:124027408 NA 0.38 7.83 0.3 2.07e-14 Total body bone mineral density; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg08470875 chr2:26401718 FAM59B -0.5 -8.06 -0.3 3.87e-15 Gut microbiome composition (summer); BRCA cis rs9393777 0.513 rs9379905 chr6:26630990 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.67 -0.32 3.58e-17 Intelligence (multi-trait analysis); BRCA cis rs9467711 0.591 rs34791189 chr6:26035806 G/A cg21479132 chr6:26055353 NA 0.59 8.31 0.31 5.6e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs17376456 0.932 rs3940842 chr5:93534858 C/A cg25358565 chr5:93447407 FAM172A 1.25 19.46 0.61 1.36e-66 Diabetic retinopathy; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg24768116 chr2:27665128 KRTCAP3 0.34 8.52 0.32 1.14e-16 Total body bone mineral density; BRCA cis rs10924970 0.967 rs12741262 chr1:235406849 T/C cg26050004 chr1:235667680 B3GALNT2 0.35 8.75 0.33 1.82e-17 Asthma; BRCA cis rs7615952 0.576 rs17523380 chr3:125802874 C/T cg15145296 chr3:125709740 NA -0.49 -8.53 -0.32 1.07e-16 Blood pressure (smoking interaction); BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 17.82 0.58 5.88e-58 Platelet count; BRCA cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg20887711 chr4:1340912 KIAA1530 -0.58 -12.78 -0.45 1.77e-33 Obesity-related traits; BRCA cis rs1401999 0.898 rs6443928 chr3:183729487 C/T cg01324343 chr3:183735012 ABCC5 0.8 20.0 0.62 1.84e-69 Anterior chamber depth; BRCA cis rs1198872 0.503 rs1627163 chr2:10954844 A/G cg15705551 chr2:10952987 PDIA6 0.45 9.34 0.35 1.64e-19 Cardiac Troponin-T levels; BRCA trans rs10242455 0.702 rs73397499 chr7:99039627 T/C cg09045935 chr12:6379348 NA 0.86 8.35 0.31 4.08e-16 Blood metabolite levels; BRCA cis rs11255291 1.000 rs7917456 chr10:7732323 A/G cg26051552 chr10:7670683 ITIH5 0.36 7.83 0.3 2.07e-14 Ovarian reserve; BRCA trans rs853679 0.599 rs156743 chr6:27967089 T/C cg01620082 chr3:125678407 NA -0.53 -8.07 -0.3 3.39e-15 Depression; BRCA cis rs12541635 0.677 rs11781234 chr8:107012342 G/T cg10147462 chr8:107024639 NA 0.39 10.61 0.39 2.5e-24 Age of smoking initiation; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg10862848 chr6:42927986 GNMT -0.36 -14.43 -0.5 4.61e-41 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.46 0.38 9.9899999999999993e-24 Calcium levels; BRCA cis rs9733 0.565 rs11804276 chr1:150685761 T/A cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs9308433 0.505 rs958304 chr1:214474241 C/T cg06198575 chr1:214491504 SMYD2 0.59 12.69 0.45 4.73e-33 IgG glycosylation; BRCA cis rs1348850 0.514 rs4893974 chr2:178497026 A/G cg27490568 chr2:178487706 NA 0.43 7.93 0.3 1.01e-14 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg22920501 chr2:26401640 FAM59B 0.91 15.61 0.53 9.09e-47 Gut microbiome composition (summer); BRCA cis rs2011503 1.000 rs8101219 chr19:19643715 G/A cg11584989 chr19:19387371 SF4 0.64 13.48 0.47 1.25e-36 Bipolar disorder; BRCA cis rs2336384 1.000 rs873457 chr1:12046334 C/G cg13216073 chr1:12042593 MFN2 0.43 9.51 0.35 3.86e-20 Platelet count; BRCA cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg06634786 chr22:41940651 POLR3H 0.58 9.62 0.36 1.49e-20 Vitiligo; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg04944784 chr2:26401820 FAM59B -0.75 -13.02 -0.46 1.51e-34 Gut microbiome composition (summer); BRCA cis rs10779751 0.770 rs2258621 chr1:11141187 C/G cg08854313 chr1:11322531 MTOR 0.74 14.86 0.51 3.98e-43 Body mass index; BRCA cis rs6456156 0.524 rs6934043 chr6:167466449 C/T cg07741184 chr6:167504864 NA 0.33 9.82 0.36 2.83e-21 Primary biliary cholangitis; BRCA cis rs6963495 0.818 rs73190149 chr7:105152793 C/T cg19920283 chr7:105172520 RINT1 0.58 9.35 0.35 1.42e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7267979 1.000 rs6050544 chr20:25320228 T/A cg08601574 chr20:25228251 PYGB -0.35 -8.55 -0.32 9.04e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1975991 0.765 rs4686940 chr3:187957193 T/C cg15417654 chr3:187959138 LPP 0.36 9.34 0.35 1.59e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs67478160 0.655 rs4900598 chr14:104281541 T/C cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.27 -0.41 5.37e-27 Schizophrenia; BRCA cis rs3733585 0.736 rs4543113 chr4:10008305 G/A cg11266682 chr4:10021025 SLC2A9 0.4 10.39 0.38 1.8e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11190604 1.000 rs76683169 chr10:102358397 A/T cg07080220 chr10:102295463 HIF1AN 0.61 11.91 0.43 1.08e-29 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg00409905 chr10:38381863 ZNF37A 0.48 9.87 0.36 1.77e-21 Extrinsic epigenetic age acceleration; BRCA cis rs4285028 0.747 rs7153 chr3:121383297 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.85 -0.48 2.53e-38 Multiple sclerosis; BRCA cis rs12618769 0.597 rs4069739 chr2:99049528 G/C cg10123293 chr2:99228465 UNC50 0.4 7.95 0.3 8.52e-15 Bipolar disorder; BRCA cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg17330251 chr7:94953956 PON1 -0.41 -8.48 -0.32 1.51e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg21782813 chr7:2030301 MAD1L1 0.39 10.18 0.37 1.22e-22 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.875 rs9322044 chr6:146369608 T/C cg05347473 chr6:146136440 FBXO30 0.4 7.91 0.3 1.16e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs858239 0.600 rs2003555 chr7:23122915 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.82 0.42 2.65e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs270601 0.633 rs733300 chr5:131572243 A/G cg09877947 chr5:131593287 PDLIM4 0.42 9.88 0.36 1.55e-21 Acylcarnitine levels; BRCA cis rs7412746 0.658 rs72704652 chr1:150819470 A/G cg18016565 chr1:150552671 MCL1 0.35 8.03 0.3 4.85e-15 Melanoma; BRCA cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg22535103 chr8:58192502 C8orf71 -0.6 -12.78 -0.45 1.85e-33 Developmental language disorder (linguistic errors); BRCA cis rs965469 0.779 rs6051710 chr20:3264661 T/C cg25506879 chr20:3388711 C20orf194 -0.44 -8.77 -0.33 1.65e-17 IFN-related cytopenia; BRCA cis rs7772486 0.686 rs9390347 chr6:146044747 G/T cg23711669 chr6:146136114 FBXO30 -0.71 -16.94 -0.56 2e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg18230493 chr5:56204884 C5orf35 0.74 14.59 0.5 8.41e-42 Initial pursuit acceleration; BRCA cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.65 0.39 1.73e-24 Motion sickness; BRCA trans rs11098499 0.955 rs11944880 chr4:120159334 A/G cg25214090 chr10:38739885 LOC399744 -0.47 -10.43 -0.38 1.25e-23 Corneal astigmatism; BRCA cis rs7647973 0.516 rs4536858 chr3:49193081 A/G cg07636037 chr3:49044803 WDR6 0.82 21.8 0.65 3.56e-79 Menarche (age at onset); BRCA cis rs2070488 0.775 rs6599208 chr3:38558104 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.71 -0.53 2.97e-47 Electrocardiographic conduction measures; BRCA cis rs701145 0.537 rs1713831 chr3:153836299 T/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.89e-18 Coronary artery disease; BRCA cis rs62064224 0.589 rs8069673 chr17:30661250 C/T cg25809561 chr17:30822961 MYO1D -0.38 -8.97 -0.33 3.33e-18 Schizophrenia; BRCA cis rs853679 0.546 rs200490 chr6:27796935 G/T cg26587870 chr6:27730563 NA -0.52 -7.99 -0.3 6.27e-15 Depression; BRCA cis rs7666738 0.830 rs13110903 chr4:98946373 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7246967 0.673 rs9677019 chr19:22912659 T/C cg23217946 chr19:22817039 ZNF492 0.5 9.16 0.34 6.71e-19 Bronchopulmonary dysplasia; BRCA trans rs1459104 0.759 rs7939392 chr11:55257285 C/T cg15704280 chr7:45808275 SEPT13 0.55 8.98 0.33 2.93e-18 Body mass index; BRCA cis rs6598955 0.671 rs12090258 chr1:26644698 C/T cg04990556 chr1:26633338 UBXN11 0.55 8.9 0.33 5.93e-18 Obesity-related traits; BRCA cis rs10242455 0.702 rs17854665 chr7:99050039 G/A cg18809830 chr7:99032528 PTCD1 -0.61 -8.86 -0.33 7.76e-18 Blood metabolite levels; BRCA cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg11764359 chr7:65958608 NA -0.72 -15.42 -0.52 7.91e-46 Aortic root size; BRCA cis rs8028182 0.537 rs4371118 chr15:75898890 C/G cg20655648 chr15:75932815 IMP3 0.46 8.86 0.33 8.2e-18 Sudden cardiac arrest; BRCA cis rs2806561 0.704 rs1757039 chr1:23508657 A/G cg12483005 chr1:23474871 LUZP1 0.46 10.27 0.38 5.48e-23 Height; BRCA cis rs11700980 0.636 rs73190119 chr21:30303685 C/A cg24692254 chr21:30365293 RNF160 -0.47 -8.07 -0.3 3.43e-15 QRS complex (12-leadsum); BRCA cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg16049864 chr8:95962084 TP53INP1 -0.46 -11.19 -0.4 1.19e-26 Type 2 diabetes; BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg12311346 chr5:56204834 C5orf35 -0.79 -15.4 -0.52 9.6e-46 Initial pursuit acceleration; BRCA cis rs68170813 0.559 rs59782202 chr7:107032766 G/T cg02696742 chr7:106810147 HBP1 -0.51 -8.45 -0.32 1.95e-16 Coronary artery disease; BRCA cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg18404041 chr3:52824283 ITIH1 -0.43 -12.64 -0.45 7.89e-33 Bipolar disorder; BRCA cis rs477692 0.673 rs1970197 chr10:131359588 C/T cg24747557 chr10:131355152 MGMT -0.37 -8.96 -0.33 3.56e-18 Response to temozolomide; BRCA cis rs10751667 0.580 rs11246363 chr11:971667 T/C cg01483505 chr11:975446 AP2A2 0.34 9.33 0.35 1.78e-19 Alzheimer's disease (late onset); BRCA cis rs3820928 0.904 rs2195487 chr2:227759720 G/C cg11843606 chr2:227700838 RHBDD1 -0.39 -8.53 -0.32 1.04e-16 Pulmonary function; BRCA cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg23788917 chr6:8435910 SLC35B3 -0.65 -12.06 -0.43 2.49e-30 Motion sickness; BRCA cis rs1568889 1.000 rs9783375 chr11:28033667 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 12.64 0.45 7.4e-33 Bipolar disorder; BRCA cis rs4742903 0.527 rs7350223 chr9:106885332 A/G cg14250997 chr9:106856677 SMC2 0.29 8.57 0.32 7.68e-17 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2153535 0.580 rs9505450 chr6:8469902 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg01262667 chr19:19385393 TM6SF2 0.42 10.97 0.4 9.28e-26 Tonsillectomy; BRCA trans rs61931739 0.517 rs56308002 chr12:34016021 C/G cg26384229 chr12:38710491 ALG10B 0.67 13.98 0.48 6.25e-39 Morning vs. evening chronotype; BRCA trans rs57221529 0.766 rs72703070 chr5:590458 T/C cg11887960 chr12:57824829 NA 0.52 8.15 0.31 1.89e-15 Lung disease severity in cystic fibrosis; BRCA cis rs703842 1.000 rs11172335 chr12:58175201 C/T cg00677455 chr12:58241039 CTDSP2 0.63 14.18 0.49 7.02e-40 Multiple sclerosis; BRCA cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs13102973 0.932 rs11099305 chr4:135895569 C/G cg14419869 chr4:135874104 NA 0.52 10.97 0.4 9.3e-26 Subjective well-being; BRCA cis rs7560272 0.538 rs17434634 chr2:73922926 T/A cg20560298 chr2:73613845 ALMS1 0.35 9.04 0.34 1.8e-18 Schizophrenia; BRCA cis rs875971 1.000 rs778722 chr7:65844828 T/C cg11764359 chr7:65958608 NA 0.81 19.67 0.61 1.05e-67 Aortic root size; BRCA cis rs7246657 0.507 rs8107654 chr19:37453534 C/T cg23950597 chr19:37808831 NA -0.6 -8.62 -0.32 5.33e-17 Coronary artery calcification; BRCA cis rs1008375 0.898 rs7670500 chr4:17586957 A/G cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs67478160 0.619 rs11628481 chr14:104241499 C/T cg08213375 chr14:104286397 PPP1R13B 0.64 18.18 0.58 7.35e-60 Schizophrenia; BRCA trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs72772090 0.710 rs11739280 chr5:96074147 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.58 12.65 0.45 6.98e-33 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9463078 0.739 rs1293457 chr6:44758098 T/C cg25276700 chr6:44698697 NA 0.38 8.92 0.33 4.79e-18 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6547741 1.000 rs7604798 chr2:27824940 T/C cg27432699 chr2:27873401 GPN1 0.46 9.71 0.36 7.18e-21 Oral cavity cancer; BRCA cis rs6938 0.534 rs12913293 chr15:75184458 G/C cg10253484 chr15:75165896 SCAMP2 -0.55 -11.44 -0.41 1.06e-27 Breast cancer; BRCA cis rs9467773 0.565 rs4343916 chr6:26522675 A/T cg11502198 chr6:26597334 ABT1 0.61 11.56 0.42 3.24e-28 Intelligence (multi-trait analysis); BRCA cis rs806795 0.605 rs6935954 chr6:26255451 A/G cg13736514 chr6:26305472 NA -0.41 -12.26 -0.44 3.58e-31 Mosquito bite size; BRCA cis rs887829 0.569 rs10179091 chr2:234657983 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.3 -7.95 -0.3 8.2e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs9814567 1.000 rs2056603 chr3:134312749 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.52 -0.61 6.62e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs801193 1.000 rs7789184 chr7:66210195 A/T cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg15112475 chr7:1198522 ZFAND2A -0.56 -12.7 -0.45 4.04e-33 Longevity;Endometriosis; BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.33e-19 Tonsillectomy; BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg00106254 chr7:1943704 MAD1L1 -0.38 -9.12 -0.34 1e-18 Bipolar disorder and schizophrenia; BRCA trans rs11088226 0.681 rs2409456 chr21:33929374 G/A cg09050820 chr6:167586206 TCP10L2 0.76 13.65 0.48 2.14e-37 Gastritis; BRCA trans rs1005277 0.579 rs2749616 chr10:38510993 A/T cg23533926 chr12:111358616 MYL2 -0.42 -8.71 -0.33 2.6e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6138458 1.000 rs4273288 chr20:24900873 G/A cg26195577 chr20:24973756 C20orf3 -0.98 -24.76 -0.7 2.17e-95 Blood protein levels; BRCA cis rs17095355 0.818 rs12572438 chr10:111769236 T/C cg00817464 chr10:111662876 XPNPEP1 -0.45 -9.74 -0.36 5.35e-21 Biliary atresia; BRCA trans rs3857536 0.813 rs6931701 chr6:66940905 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs9486719 0.843 rs2499789 chr6:96844510 T/C cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs7772486 0.641 rs960385 chr6:146371074 G/A cg13319975 chr6:146136371 FBXO30 -0.55 -12.13 -0.43 1.31e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg22800045 chr5:56110881 MAP3K1 -0.51 -8.5 -0.32 1.32e-16 Initial pursuit acceleration; BRCA cis rs7267979 1.000 rs4813562 chr20:25352588 G/A cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7246657 0.722 rs2287229 chr19:38188652 G/A cg18154014 chr19:37997991 ZNF793 -0.51 -9.64 -0.36 1.27e-20 Coronary artery calcification; BRCA cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg02275930 chr1:2372054 NA -0.42 -9.97 -0.37 7.43e-22 Non-obstructive azoospermia; BRCA cis rs10493773 0.609 rs6689168 chr1:86174232 G/T cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.26 -0.46 1.27e-35 Urate levels in overweight individuals; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg27170947 chr2:26402098 FAM59B -0.62 -10.73 -0.39 8.53e-25 Gut microbiome composition (summer); BRCA cis rs6840360 0.533 rs13139327 chr4:152728590 A/C cg22705602 chr4:152727874 NA -0.39 -10.57 -0.39 3.52e-24 Intelligence (multi-trait analysis); BRCA cis rs7520050 0.966 rs1707340 chr1:46514942 T/C cg24296786 chr1:45957014 TESK2 0.41 9.22 0.34 4.28e-19 Red blood cell count;Reticulocyte count; BRCA cis rs7552404 0.924 rs1146580 chr1:76209935 T/C cg03433033 chr1:76189801 ACADM 0.73 18.63 0.59 3.43e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6598955 0.543 rs60676610 chr1:26543421 G/C cg04990556 chr1:26633338 UBXN11 0.7 11.96 0.43 6.68e-30 Obesity-related traits; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg00802000 chr16:706648 WDR90 -0.41 -9.69 -0.36 8.16e-21 Height; BRCA cis rs4363385 0.818 rs426360 chr1:153014710 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.62 -0.32 5.11e-17 Inflammatory skin disease; BRCA cis rs6878727 0.707 rs7717536 chr5:123718821 C/T cg01806427 chr5:123737813 NA 0.39 9.04 0.34 1.85e-18 Breast cancer; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg24101359 chr6:42928495 GNMT 0.62 14.99 0.51 9.23e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs35740288 0.929 rs11556865 chr15:86303180 C/G cg20737812 chr15:86336631 KLHL25 -0.33 -8.09 -0.3 2.99e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs6121246 0.559 rs6060915 chr20:30330306 A/G cg13852791 chr20:30311386 BCL2L1 0.93 22.13 0.66 5.66e-81 Mean corpuscular hemoglobin; BRCA cis rs514406 0.621 rs928452 chr1:53195926 G/C cg24675658 chr1:53192096 ZYG11B 0.68 14.68 0.5 2.81e-42 Monocyte count; BRCA cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg16325326 chr1:53192061 ZYG11B 0.73 18.75 0.6 7.85e-63 Monocyte count; BRCA trans rs3780486 0.713 rs3780489 chr9:33129844 G/T cg20290983 chr6:43655470 MRPS18A 1.1 40.87 0.85 2e-180 IgG glycosylation; BRCA cis rs9733 0.519 rs11807450 chr1:150677719 C/T cg04414720 chr1:150670196 GOLPH3L 0.36 8.21 0.31 1.2e-15 Tonsillectomy; BRCA cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4819852 1.000 rs2073743 chr22:19989612 C/G cg07821417 chr22:19972146 ARVCF 0.49 10.4 0.38 1.67e-23 Pulse pressure; BRCA cis rs3733585 0.699 rs7683283 chr4:9969974 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.66e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.545 rs6460298 chr7:65907770 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 9.98 0.37 7.04e-22 Aortic root size; BRCA cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg16230307 chr14:35515116 FAM177A1 0.72 14.91 0.51 2.41e-43 Psoriasis; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg05552183 chr6:42928497 GNMT 0.8 19.33 0.61 6.54e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg23708337 chr7:1209742 NA 0.6 13.68 0.48 1.45e-37 Longevity;Endometriosis; BRCA cis rs9986765 0.881 rs73452602 chr7:142828331 A/T cg21852589 chr7:142981689 TMEM139 0.56 9.65 0.36 1.12e-20 Cancer;Dermatomyositis; BRCA cis rs7264396 0.563 rs6060558 chr20:34271092 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.81 -0.39 3.84e-25 Total cholesterol levels; BRCA cis rs826838 0.967 rs826879 chr12:39088999 A/C cg26384229 chr12:38710491 ALG10B -0.63 -16.51 -0.55 2.96e-51 Heart rate; BRCA cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs9837602 1.000 rs2291494 chr3:99781805 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.21 0.41 9.77e-27 Breast cancer; BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.14 0.34 7.92e-19 Platelet count; BRCA cis rs9287719 0.967 rs6755548 chr2:10746126 A/G cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs2130392 1.000 rs873686 chr4:185638876 A/G cg21366198 chr4:185655624 MLF1IP 0.38 9.38 0.35 1.1e-19 Kawasaki disease; BRCA cis rs6745190 0.575 rs62178846 chr2:181973399 G/A cg00481216 chr2:181971175 NA 0.4 9.41 0.35 8.62e-20 White blood cell count; BRCA cis rs752010 0.875 rs11210502 chr1:42093712 A/C cg06885757 chr1:42089581 HIVEP3 0.3 10.65 0.39 1.77e-24 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs4819052 1.000 rs13053002 chr21:46677854 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.63 11.2 0.4 1.07e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1595825 0.891 rs75373125 chr2:198657044 G/A cg19156104 chr2:198669113 PLCL1 -0.49 -8.43 -0.32 2.34e-16 Ulcerative colitis; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.42 9.37 0.35 1.2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9858542 0.953 rs9814873 chr3:49454112 A/G cg03060546 chr3:49711283 APEH -0.49 -9.87 -0.36 1.79e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg11663144 chr21:46675770 NA -0.64 -15.28 -0.52 3.72e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11098499 0.863 rs1552092 chr4:120488496 C/T cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 11.34 0.41 2.83e-27 Personality dimensions; BRCA cis rs10267417 0.535 rs6956976 chr7:19869168 G/A cg05791153 chr7:19748676 TWISTNB 0.5 9.54 0.35 3.01e-20 Night sleep phenotypes; BRCA cis rs2762353 0.603 rs10946798 chr6:25781853 T/G cg12310025 chr6:25882481 NA 0.4 9.17 0.34 6.68e-19 Blood metabolite levels; BRCA cis rs6963495 0.818 rs6943132 chr7:105166776 C/T cg19920283 chr7:105172520 RINT1 0.59 8.45 0.32 2.02e-16 Bipolar disorder (body mass index interaction); BRCA cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.45e-16 Bipolar disorder; BRCA cis rs4074536 0.622 rs10802001 chr1:116315610 A/T cg21648376 chr1:116311395 CASQ2 -0.54 -8.98 -0.33 3.02e-18 QRS duration; BRCA cis rs921968 0.541 rs599973 chr2:219387273 C/G cg02176678 chr2:219576539 TTLL4 0.46 11.93 0.43 8.95e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs2549003 1.000 rs7734334 chr5:131815004 C/A cg21138405 chr5:131827807 IRF1 0.4 13.0 0.46 1.85e-34 Asthma (sex interaction); BRCA trans rs7824557 0.701 rs2060465 chr8:11162609 T/C cg06636001 chr8:8085503 FLJ10661 0.53 10.1 0.37 2.44e-22 Retinal vascular caliber; BRCA cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14442939 chr10:27389572 ANKRD26 0.72 14.17 0.49 8.17e-40 Breast cancer; BRCA cis rs11792861 0.591 rs10979632 chr9:111732140 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 12.98 0.46 2.2e-34 Menarche (age at onset); BRCA cis rs9486719 0.948 rs11153059 chr6:97014537 T/A cg06623918 chr6:96969491 KIAA0776 -0.76 -13.7 -0.48 1.19e-37 Migraine;Coronary artery disease; BRCA cis rs3925075 0.584 rs12600286 chr16:31360679 G/C cg02846316 chr16:31340340 ITGAM 0.5 11.87 0.42 1.72e-29 IgA nephropathy; BRCA cis rs4664304 0.658 rs2667012 chr2:160867553 G/T cg01092293 chr2:160761427 LY75 -0.36 -8.75 -0.33 1.85e-17 Crohn's disease;Inflammatory bowel disease; BRCA cis rs17401966 1.000 rs12129035 chr1:10291166 G/A cg15208524 chr1:10270712 KIF1B 0.37 8.24 0.31 9.770000000000001e-16 Hepatocellular carcinoma; BRCA cis rs1538970 0.961 rs7553318 chr1:45843086 A/G cg05343316 chr1:45956843 TESK2 0.58 11.89 0.43 1.38e-29 Platelet count; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg23708337 chr7:1209742 NA 0.64 9.98 0.37 7.05e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4664304 0.620 rs2357691 chr2:160725139 A/G cg01092293 chr2:160761427 LY75 -0.35 -8.23 -0.31 1.08e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg00254258 chr1:3105189 PRDM16 -0.48 -11.15 -0.4 1.67e-26 Migraine; BRCA cis rs7246657 0.722 rs1531549 chr19:38088009 T/C cg18154014 chr19:37997991 ZNF793 0.48 9.15 0.34 7.66e-19 Coronary artery calcification; BRCA trans rs7618501 0.633 rs4688690 chr3:50022292 G/A cg21659725 chr3:3221576 CRBN 0.48 12.09 0.43 1.86e-30 Intelligence (multi-trait analysis); BRCA cis rs17095355 0.901 rs10884919 chr10:111757791 G/A cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.67 -0.36 9.59e-21 Biliary atresia; BRCA cis rs11249608 0.789 rs7706393 chr5:178437737 G/T cg21905437 chr5:178450457 ZNF879 -0.44 -9.16 -0.34 6.75e-19 Pubertal anthropometrics; BRCA cis rs1475911 1.000 rs1475911 chr21:43513480 A/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.61 11.39 0.41 1.65e-27 IgG glycosylation; BRCA cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg11168104 chr5:1857477 NA -0.32 -8.45 -0.32 1.93e-16 Cardiovascular disease risk factors; BRCA cis rs977987 0.735 rs166013 chr16:75434146 C/T cg03315344 chr16:75512273 CHST6 -0.55 -12.68 -0.45 4.85e-33 Dupuytren's disease; BRCA cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg15017067 chr4:17643749 FAM184B 0.28 8.6 0.32 6.13e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg11941060 chr3:133502564 NA -0.41 -9.02 -0.34 2.17e-18 Iron status biomarkers; BRCA cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg10560079 chr2:191398806 TMEM194B 0.71 12.52 0.44 2.48e-32 Diastolic blood pressure; BRCA cis rs17401966 0.931 rs11584023 chr1:10302596 A/G cg19773385 chr1:10388646 KIF1B -0.36 -7.97 -0.3 7.53e-15 Hepatocellular carcinoma; BRCA cis rs3733585 0.736 rs4543113 chr4:10008305 G/A cg00071950 chr4:10020882 SLC2A9 0.5 11.65 0.42 1.43e-28 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6912958 0.535 rs242283 chr6:88030931 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.62 12.83 0.45 1.14e-33 Monocyte percentage of white cells; BRCA cis rs12618769 0.597 rs17502889 chr2:99031745 A/G cg10123293 chr2:99228465 UNC50 0.42 8.17 0.31 1.68e-15 Bipolar disorder; BRCA cis rs2404602 0.716 rs1588961 chr15:76752698 A/G cg22467129 chr15:76604101 ETFA -0.5 -10.82 -0.39 3.63e-25 Blood metabolite levels; BRCA cis rs9811920 0.535 rs1610509 chr3:99474327 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.42 9.9 0.36 1.32e-21 Axial length; BRCA cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.53 0.44 2.42e-32 Age-related macular degeneration (geographic atrophy); BRCA cis rs507080 0.922 rs546890 chr11:118557198 T/C cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA cis rs6570726 0.791 rs385729 chr6:145855465 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.35 -0.35 1.45e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs933688 1.000 rs7720132 chr5:90745105 T/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 16.3 0.54 3.31e-50 Smoking behavior; BRCA cis rs4665809 0.590 rs4665837 chr2:26434022 C/A cg22920501 chr2:26401640 FAM59B -0.95 -16.82 -0.55 7.55e-53 Gut microbiome composition (summer); BRCA cis rs4713118 0.621 rs9295756 chr6:28033396 G/T cg16479474 chr6:28041457 NA 0.43 7.93 0.3 9.63e-15 Parkinson's disease; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg09060608 chr5:178986726 RUFY1 -0.58 -14.89 -0.51 2.94e-43 Lung cancer; BRCA cis rs6460942 0.841 rs6968277 chr7:12443795 C/A cg20607287 chr7:12443886 VWDE -0.5 -8.6 -0.32 6.03e-17 Coronary artery disease; BRCA cis rs727479 0.502 rs7167936 chr15:51499545 A/G cg19946085 chr15:51559439 CYP19A1 -0.3 -8.26 -0.31 8.13e-16 Estradiol levels; BRCA cis rs17401966 0.931 rs12130563 chr1:10428452 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.27 -0.31 7.87e-16 Hepatocellular carcinoma; BRCA cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.95 -0.3 8.57e-15 Ulcerative colitis; BRCA cis rs12472274 0.646 rs10929269 chr2:239097423 A/G cg17459225 chr2:239074497 NA 0.59 10.52 0.38 5.65e-24 Phospholipid levels (plasma); BRCA cis rs4074536 0.622 rs3827736 chr1:116313263 C/G cg21648376 chr1:116311395 CASQ2 -0.52 -8.67 -0.32 3.55e-17 QRS duration; BRCA cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg08508325 chr11:3079039 CARS -0.41 -14.23 -0.49 4.11e-40 Longevity; BRCA cis rs7552404 0.731 rs61770552 chr1:76373050 T/C cg10523679 chr1:76189770 ACADM 0.69 11.95 0.43 7.32e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1797081 1.000 rs1797081 chr10:16874565 A/G cg23933602 chr10:16859644 RSU1 0.94 28.08 0.74 1.27e-113 Platelet distribution width; BRCA cis rs7246657 0.524 rs10411251 chr19:37428755 C/T cg18154014 chr19:37997991 ZNF793 0.49 8.75 0.33 1.88e-17 Coronary artery calcification; BRCA trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg13010199 chr12:38710504 ALG10B 0.5 9.86 0.36 1.88e-21 Morning vs. evening chronotype; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg22920501 chr2:26401640 FAM59B 0.9 16.44 0.55 6.44e-51 Gut microbiome composition (summer); BRCA cis rs2276314 0.857 rs4799408 chr18:33588982 C/T cg19628046 chr18:33552617 C18orf21 -0.55 -11.36 -0.41 2.27e-27 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs12612619 0.732 rs7560595 chr2:27229372 C/G cg00617064 chr2:27272375 NA -0.33 -8.71 -0.33 2.66e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 8.91 0.33 5.19e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg04944784 chr2:26401820 FAM59B -0.69 -11.36 -0.41 2.25e-27 Gut microbiome composition (summer); BRCA cis rs243505 0.965 rs243503 chr7:148436106 G/C cg09806900 chr7:148480153 CUL1 -0.43 -8.69 -0.33 3.05e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs812925 0.537 rs2463097 chr2:61614301 G/C cg15711740 chr2:61764176 XPO1 0.32 8.02 0.3 4.89e-15 Immature fraction of reticulocytes; BRCA cis rs116979167 0.630 rs56230603 chr7:105165268 A/G cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7246657 0.943 rs7258692 chr19:37818829 C/A cg18154014 chr19:37997991 ZNF793 0.54 10.44 0.38 1.11e-23 Coronary artery calcification; BRCA cis rs55788414 0.505 rs7190949 chr16:81189583 C/T cg06400318 chr16:81190750 PKD1L2 0.56 11.47 0.41 8.22e-28 Left ventricular obstructive tract defect (maternal effect); BRCA cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 3.02e-25 Bipolar disorder; BRCA cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg18404041 chr3:52824283 ITIH1 -0.48 -14.44 -0.5 4.03e-41 Bipolar disorder; BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg14004847 chr7:1930337 MAD1L1 -0.45 -9.13 -0.34 8.86e-19 Bipolar disorder and schizophrenia; BRCA cis rs829883 0.714 rs249847 chr12:98867716 C/T cg25150519 chr12:98850993 NA 0.68 16.69 0.55 3.52e-52 Colorectal adenoma (advanced); BRCA cis rs941873 0.868 rs7332 chr10:81114060 G/A cg09469691 chr10:81107165 PPIF 0.53 11.06 0.4 3.99e-26 Height; BRCA cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg11833968 chr6:79620685 NA -0.42 -9.28 -0.34 2.68e-19 Intelligence (multi-trait analysis); BRCA cis rs8032158 1.000 rs66462353 chr15:56186767 T/C cg02198044 chr15:56286336 NEDD4 -0.38 -9.26 -0.34 3.1e-19 Keloid; BRCA cis rs1707322 0.721 rs12069121 chr1:46231984 G/A cg03146154 chr1:46216737 IPP 0.54 12.14 0.43 1.17e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs919433 0.680 rs6710530 chr2:198277551 G/A cg00792783 chr2:198669748 PLCL1 0.38 8.45 0.32 1.91e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs919433 1.000 rs1346649 chr2:198166117 C/A cg03934865 chr2:198174659 NA -0.39 -8.29 -0.31 6.66e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6745190 0.575 rs11678264 chr2:181976494 T/C cg00481216 chr2:181971175 NA 0.4 9.45 0.35 6.15e-20 White blood cell count; BRCA cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs16976116 0.901 rs1061875 chr15:55496278 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg00686598 chr14:53173677 PSMC6 1.15 15.36 0.52 1.45e-45 Alzheimer's disease (late onset); BRCA cis rs10504229 0.683 rs6999351 chr8:58127227 C/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA trans rs35110281 0.667 rs2155722 chr21:45096206 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.37 -7.92 -0.3 1.09e-14 Mean corpuscular volume; BRCA cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.63 0.55 7.2e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs6426558 0.537 rs4351610 chr1:227325245 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -9.3 -0.35 2.13e-19 Neutrophil percentage of white cells; BRCA cis rs6461049 0.765 rs4719431 chr7:2140312 T/C cg02951883 chr7:2050386 MAD1L1 -0.5 -12.29 -0.44 2.6e-31 Schizophrenia; BRCA cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.88 0.3 1.37e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 0.679 rs72793818 chr16:28893137 G/A cg16576597 chr16:28551801 NUPR1 0.3 8.26 0.31 8.25e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg23978390 chr7:1156363 C7orf50 0.4 9.13 0.34 8.78e-19 Longevity;Endometriosis; BRCA cis rs8114671 0.967 rs1415773 chr20:33765585 G/A cg07148914 chr20:33460835 GGT7 0.39 8.28 0.31 7.4e-16 Height; BRCA cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.83 0.3 1.98e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10754283 0.967 rs7519971 chr1:90108743 G/A cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs4975616 0.686 rs37008 chr5:1351538 C/T cg07493874 chr5:1342172 CLPTM1L -0.47 -13.19 -0.46 2.58e-35 Lung cancer; BRCA cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg06640241 chr16:89574553 SPG7 -0.51 -11.13 -0.4 2.04e-26 Multiple myeloma (IgH translocation); BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 7.98 0.3 6.6e-15 Tonsillectomy; BRCA cis rs9818758 0.607 rs34580506 chr3:49113713 C/A cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg21479132 chr6:26055353 NA 0.55 7.9 0.3 1.19e-14 Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.517 rs2101396 chr12:34048927 T/A cg26384229 chr12:38710491 ALG10B 0.51 11.26 0.41 5.83e-27 Morning vs. evening chronotype; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7903847 0.642 rs11189183 chr10:99144321 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.6 -0.32 6.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10876993 0.826 rs1678534 chr12:58057435 A/C cg18357645 chr12:58087776 OS9 0.42 11.95 0.43 7.61e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs2985684 1.000 rs2985697 chr14:50092902 A/G cg04989706 chr14:50066350 PPIL5 -0.47 -9.03 -0.34 2.02e-18 Carotid intima media thickness; BRCA cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg04727924 chr7:799746 HEATR2 -0.55 -10.8 -0.39 4.25e-25 Cerebrospinal P-tau181p levels; BRCA cis rs2836974 0.897 rs14194 chr21:40549466 T/C cg11890956 chr21:40555474 PSMG1 1.03 29.72 0.76 1.41e-122 Cognitive function; BRCA cis rs9527 0.590 rs7910900 chr10:104829898 C/T cg04362960 chr10:104952993 NT5C2 0.45 10.09 0.37 2.55e-22 Arsenic metabolism; BRCA trans rs6582630 0.519 rs4405392 chr12:38293661 A/C cg06521331 chr12:34319734 NA -0.47 -8.77 -0.33 1.59e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs654351 0.572 rs813274 chr6:10387731 C/T cg04978078 chr6:10383147 NA -0.44 -8.58 -0.32 7.38e-17 Squamous cell lung carcinoma; BRCA cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg12935359 chr14:103987150 CKB -0.59 -14.12 -0.49 1.39e-39 Body mass index; BRCA cis rs514406 0.584 rs7524702 chr1:53197830 G/A cg24675658 chr1:53192096 ZYG11B 0.68 14.64 0.5 4.53e-42 Monocyte count; BRCA cis rs7917772 0.502 rs2296583 chr10:104244322 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.76 0.62 3.43e-68 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg21782813 chr7:2030301 MAD1L1 0.36 10.26 0.38 5.73e-23 Bipolar disorder and schizophrenia; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.67 -13.54 -0.47 6.81e-37 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2576037 0.526 rs642897 chr18:44396917 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.61 0.32 5.79e-17 Personality dimensions; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg10150615 chr22:24372951 LOC391322 0.43 9.47 0.35 5.46e-20 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1182196 0.533 rs2527521 chr7:2904928 A/G cg04166393 chr7:2884313 GNA12 -0.41 -9.04 -0.34 1.79e-18 Plateletcrit; BRCA cis rs13394619 0.875 rs7576826 chr2:11723021 C/T cg07314298 chr2:11723111 GREB1 -0.56 -12.21 -0.43 5.69e-31 Endometriosis; BRCA cis rs3741404 0.825 rs11604782 chr11:63946650 G/A cg18225595 chr11:63971243 STIP1 0.58 13.78 0.48 4.96e-38 Platelet count; BRCA cis rs7772486 0.790 rs9497424 chr6:146225271 C/A cg23711669 chr6:146136114 FBXO30 -0.68 -15.81 -0.53 8.7e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs6137287 0.668 rs6047258 chr20:21098277 A/C cg04219410 chr20:21106687 PLK1S1 0.35 8.19 0.31 1.41e-15 Height; BRCA trans rs853679 0.766 rs9368561 chr6:28168343 C/T cg01620082 chr3:125678407 NA -0.56 -8.06 -0.3 3.9e-15 Depression; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.84 0.55 6.2e-53 Gut microbiome composition (summer); BRCA cis rs877282 0.898 rs71489279 chr10:760510 T/C cg17470449 chr10:769945 NA 0.47 8.07 0.3 3.41e-15 Uric acid levels; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg08470875 chr2:26401718 FAM59B 0.72 10.14 0.37 1.67e-22 Gut microbiome composition (summer); BRCA cis rs929596 0.583 rs77070100 chr2:234587847 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.35 -8.94 -0.33 4.02e-18 Total bilirubin levels in HIV-1 infection; BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.11 0.34 1.07e-18 Tonsillectomy; BRCA cis rs10789491 1.000 rs7547522 chr1:47179918 C/G cg15501359 chr1:47185051 KIAA0494 0.65 18.17 0.58 8.75e-60 Response to hepatitis C treatment; BRCA cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg14863265 chr7:2801509 GNA12 -0.37 -8.43 -0.32 2.3e-16 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg04450456 chr4:17643702 FAM184B 0.38 10.19 0.37 1.11e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7246657 0.722 rs1564206 chr19:38040076 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.11 0.34 1.03e-18 Coronary artery calcification; BRCA cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.49 0.32 1.4e-16 Electroencephalogram traits; BRCA cis rs57590327 0.504 rs13065281 chr3:81693550 G/A cg07356753 chr3:81810745 GBE1 -0.43 -9.83 -0.36 2.4e-21 Extraversion; BRCA cis rs868036 1.000 rs6494696 chr15:68103206 C/G cg05925327 chr15:68127851 NA 0.31 7.84 0.3 1.92e-14 Restless legs syndrome; BRCA cis rs6541297 1.000 rs4846909 chr1:230285372 G/A cg20703242 chr1:230279135 GALNT2 0.46 10.24 0.38 6.78e-23 Coronary artery disease; BRCA cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6450176 1.000 rs12654393 chr5:53302620 A/C ch.5.1024479R chr5:53302184 ARL15 0.65 15.95 0.53 1.95e-48 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05901451 chr6:126070800 HEY2 -0.56 -14.96 -0.51 1.32e-43 Brugada syndrome; BRCA cis rs1707322 1.000 rs6682683 chr1:46342337 A/G cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.08e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs910316 0.737 rs175065 chr14:75494983 T/C cg11812906 chr14:75593930 NEK9 -0.62 -14.16 -0.49 8.75e-40 Height; BRCA cis rs782590 0.738 rs4312532 chr2:55812061 A/G cg18811423 chr2:55921094 PNPT1 -0.6 -16.91 -0.56 2.63e-53 Metabolic syndrome; BRCA cis rs7617773 0.817 rs34225441 chr3:48308891 T/A cg11946769 chr3:48343235 NME6 0.68 13.71 0.48 1.09e-37 Coronary artery disease; BRCA cis rs9420 0.961 rs7936998 chr11:57639017 G/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.53 -0.44 2.21e-32 Schizophrenia; BRCA cis rs425277 0.606 rs262653 chr1:2090095 T/G cg04315214 chr1:2043799 PRKCZ -0.48 -13.39 -0.47 3.23e-36 Height; BRCA cis rs9487051 0.738 rs171272 chr6:109530094 T/C cg01475377 chr6:109611718 NA -0.42 -10.46 -0.38 9.29e-24 Reticulocyte fraction of red cells; BRCA cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg05868516 chr6:26286170 HIST1H4H 0.51 11.24 0.41 7.44e-27 Educational attainment; BRCA cis rs7809950 1.000 rs2712200 chr7:107142435 G/T cg23024343 chr7:107201750 COG5 -0.4 -9.12 -0.34 9.56e-19 Coronary artery disease; BRCA cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg11301795 chr4:187892539 NA -0.28 -9.46 -0.35 5.83e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs61931739 0.500 rs12809868 chr12:34464905 C/T cg06521331 chr12:34319734 NA -0.56 -10.12 -0.37 2.03e-22 Morning vs. evening chronotype; BRCA cis rs7246657 0.943 rs7252099 chr19:37933780 G/A cg18154014 chr19:37997991 ZNF793 0.62 11.63 0.42 1.75e-28 Coronary artery calcification; BRCA cis rs2346177 0.542 rs718849 chr2:46698116 G/A cg02822958 chr2:46747628 ATP6V1E2 0.57 11.13 0.4 1.98e-26 HDL cholesterol; BRCA cis rs6750047 0.566 rs1157185 chr2:38285735 C/T cg07380506 chr2:38303506 CYP1B1 0.44 10.68 0.39 1.31e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs6484504 0.576 rs208091 chr11:31190099 G/C cg06552810 chr11:31128660 NA -0.39 -8.58 -0.32 7.04e-17 Red blood cell count; BRCA cis rs595982 0.527 rs73061656 chr19:49372355 G/A cg15549821 chr19:49342101 PLEKHA4 -0.71 -11.43 -0.41 1.2100000000000001e-27 Red cell distribution width; BRCA cis rs11098499 0.954 rs3733520 chr4:120423480 C/G cg09307838 chr4:120376055 NA 0.77 17.17 0.56 1.25e-54 Corneal astigmatism; BRCA cis rs2075371 0.966 rs2544223 chr7:133995787 A/G cg11752832 chr7:134001865 SLC35B4 0.55 14.14 0.49 1.12e-39 Mean platelet volume; BRCA cis rs3784262 0.669 rs4646592 chr15:58302557 A/G cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.99 -0.37 5.97e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7631605 0.905 rs9876116 chr3:37083740 A/G cg15934958 chr3:37212084 LRRFIP2 0.4 9.33 0.35 1.67e-19 Cerebrospinal P-tau181p levels; BRCA cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.84 0.42 2.3e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2637266 0.935 rs2579719 chr10:78400026 A/G cg18941641 chr10:78392320 NA 0.36 8.27 0.31 7.61e-16 Pulmonary function; BRCA cis rs6582630 0.576 rs2387836 chr12:38560070 A/G cg26384229 chr12:38710491 ALG10B 0.45 10.28 0.38 4.99e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs965469 0.895 rs6051840 chr20:3391483 C/T cg25506879 chr20:3388711 C20orf194 0.57 11.5 0.41 6.19e-28 IFN-related cytopenia; BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.77 -13.56 -0.47 5.25e-37 Gut microbiome composition (summer); BRCA cis rs4363385 0.818 rs436621 chr1:153005492 A/G cg21543102 chr1:152974771 SPRR3 -0.28 -7.81 -0.3 2.39e-14 Inflammatory skin disease; BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg08470875 chr2:26401718 FAM59B 0.72 11.26 0.41 6.14e-27 Gut microbiome composition (summer); BRCA cis rs4363385 0.818 rs1334850 chr1:153004519 G/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.59 -0.32 6.5e-17 Inflammatory skin disease; BRCA cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg16339924 chr4:17578868 LAP3 0.6 14.63 0.5 5.01e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg03354898 chr7:1950403 MAD1L1 -0.47 -9.79 -0.36 3.41e-21 Schizophrenia; BRCA cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg01475735 chr3:40494733 NA 0.47 9.88 0.36 1.65e-21 Renal cell carcinoma; BRCA cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg11608241 chr8:8085544 FLJ10661 0.28 7.83 0.3 2.08e-14 Neuroticism; BRCA cis rs1865760 0.622 rs10946807 chr6:26079638 T/C cg17691542 chr6:26056736 HIST1H1C 0.66 13.72 0.48 1.02e-37 Height; BRCA trans rs7615952 0.515 rs7630575 chr3:125682330 A/G cg07211511 chr3:129823064 LOC729375 -0.62 -11.46 -0.41 8.62e-28 Blood pressure (smoking interaction); BRCA cis rs17345786 1.000 rs73863360 chr3:101316837 G/A cg11279151 chr3:101281821 RG9MTD1 -0.51 -10.61 -0.39 2.38e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1776421 0.760 rs61768413 chr1:53904746 C/T cg10892335 chr1:53966318 NA 0.49 7.92 0.3 1.04e-14 PR interval in Tripanosoma cruzi seropositivity; BRCA cis rs12410462 1.000 rs6672162 chr1:227632335 G/A cg23173402 chr1:227635558 NA 0.5 9.15 0.34 7.32e-19 Major depressive disorder; BRCA cis rs2839186 0.632 rs17176110 chr21:47706535 C/A cg12516959 chr21:47718080 NA -0.35 -8.59 -0.32 6.62e-17 Testicular germ cell tumor; BRCA cis rs4808199 0.947 rs2099333 chr19:19605963 C/T cg03709012 chr19:19516395 GATAD2A 1.07 20.84 0.64 5.14e-74 Nonalcoholic fatty liver disease; BRCA cis rs7560272 0.501 rs12713793 chr2:73956114 T/C cg20560298 chr2:73613845 ALMS1 0.33 8.6 0.32 6.02e-17 Schizophrenia; BRCA cis rs1801251 1.000 rs1446308 chr2:233639309 T/C cg25237894 chr2:233734115 C2orf82 0.38 10.95 0.4 1.06e-25 Coronary artery disease; BRCA cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7618501 0.633 rs9853222 chr3:50022926 T/C cg24308560 chr3:49941425 MST1R -0.4 -8.52 -0.32 1.17e-16 Intelligence (multi-trait analysis); BRCA cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.43 -0.41 1.22e-27 Schizophrenia; BRCA cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.92 0.37 1.11e-21 Bipolar disorder; BRCA cis rs55882075 0.936 rs34646062 chr5:179186318 A/G cg14593053 chr5:179126677 CANX -0.4 -10.25 -0.38 6.02e-23 Monocyte percentage of white cells; BRCA cis rs796364 0.616 rs2140486 chr2:200690102 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.34 0.31 4.49e-16 Schizophrenia; BRCA cis rs9733 0.650 rs61820165 chr1:150555987 C/T cg18016565 chr1:150552671 MCL1 -0.47 -10.65 -0.39 1.79e-24 Tonsillectomy; BRCA cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.903 rs12250937 chr10:900209 C/T cg26597838 chr10:835615 NA 0.98 17.29 0.56 3.06e-55 Eosinophil percentage of granulocytes; BRCA cis rs7772486 0.720 rs4896837 chr6:146014168 C/T cg13319975 chr6:146136371 FBXO30 0.39 9.01 0.34 2.4e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs826838 0.900 rs9739128 chr12:38948960 A/T cg13010199 chr12:38710504 ALG10B 0.54 11.78 0.42 3.98e-29 Heart rate; BRCA trans rs7824557 0.564 rs2736295 chr8:11234780 C/G cg06636001 chr8:8085503 FLJ10661 0.49 10.6 0.39 2.82e-24 Retinal vascular caliber; BRCA cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg01475377 chr6:109611718 NA -0.51 -12.85 -0.45 8.96e-34 Reticulocyte fraction of red cells; BRCA cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg01181863 chr3:195395398 SDHAP2 -0.47 -8.23 -0.31 1.09e-15 Pancreatic cancer; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.62 10.2 0.37 9.79e-23 Renal function-related traits (BUN); BRCA cis rs7666738 0.830 rs6532720 chr4:99043781 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1011018 0.628 rs10254826 chr7:139433480 T/C cg03224163 chr7:139420300 HIPK2 -0.54 -9.14 -0.34 8.03e-19 Systolic blood pressure; BRCA cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg20476274 chr7:133979776 SLC35B4 0.7 21.43 0.65 3.5e-77 Mean platelet volume; BRCA trans rs61931739 0.517 rs4931771 chr12:34044557 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.85e-20 Morning vs. evening chronotype; BRCA cis rs1451375 0.583 rs11575320 chr7:50605298 A/G cg18232548 chr7:50535776 DDC -0.43 -8.99 -0.33 2.88e-18 Malaria; BRCA cis rs826838 0.510 rs10506129 chr12:39224242 A/T cg13010199 chr12:38710504 ALG10B 0.44 8.48 0.32 1.53e-16 Heart rate; BRCA cis rs801193 0.773 rs801207 chr7:66020590 T/C cg11764359 chr7:65958608 NA -0.62 -13.32 -0.47 7.04e-36 Aortic root size; BRCA cis rs1153858 1.000 rs7169587 chr15:45640379 A/G cg14582100 chr15:45693742 SPATA5L1 0.37 11.92 0.43 1e-29 Homoarginine levels; BRCA cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg24642439 chr20:33292090 TP53INP2 -0.41 -8.22 -0.31 1.14e-15 Height; BRCA trans rs11976180 1.000 rs1540894 chr7:143767676 T/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.47 -8.65 -0.32 4.07e-17 Obesity-related traits; BRCA cis rs6964587 0.773 rs12740 chr7:92029302 A/G cg17063962 chr7:91808500 NA 0.51 11.28 0.41 5.02e-27 Breast cancer; BRCA cis rs6598955 0.671 rs17163751 chr1:26568698 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs7809950 0.861 rs10264412 chr7:107183877 G/A cg23024343 chr7:107201750 COG5 -0.49 -10.03 -0.37 4.26e-22 Coronary artery disease; BRCA cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.19 0.46 2.5e-35 Schizophrenia; BRCA cis rs2836950 0.561 rs34705151 chr21:40553344 G/A cg17971929 chr21:40555470 PSMG1 -0.49 -10.72 -0.39 8.75e-25 Menarche (age at onset); BRCA cis rs896854 0.738 rs509594 chr8:95967156 C/G cg13393036 chr8:95962371 TP53INP1 0.34 8.25 0.31 8.77e-16 Type 2 diabetes; BRCA cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs10746514 0.931 rs11582890 chr1:232251218 C/T cg09506761 chr1:232265262 NA 0.4 8.07 0.3 3.5e-15 Response to statin therapy; BRCA cis rs9682041 0.932 rs1525362 chr3:170070702 C/T cg11886554 chr3:170076028 SKIL 0.69 12.88 0.45 6.52e-34 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg19077165 chr18:44547161 KATNAL2 0.55 12.48 0.44 3.7e-32 Personality dimensions; BRCA cis rs10492096 0.947 rs10849483 chr12:6635374 G/A cg13857086 chr12:6580257 VAMP1 0.43 8.26 0.31 8.61e-16 Hip geometry; BRCA cis rs765787 0.530 rs4775819 chr15:45525966 C/T cg24006582 chr15:45444508 DUOX1 -0.53 -10.83 -0.39 3.42e-25 Uric acid levels; BRCA cis rs1865760 0.593 rs9393676 chr6:25936944 G/A cg12310025 chr6:25882481 NA -0.38 -8.79 -0.33 1.34e-17 Height; BRCA cis rs9463078 0.665 rs227849 chr6:44698708 C/T cg25276700 chr6:44698697 NA 0.4 9.47 0.35 5.48e-20 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.32 -10.32 -0.38 3.51e-23 Autism spectrum disorder or schizophrenia; BRCA cis rs67460515 0.892 rs4856756 chr3:160999414 G/A cg03342759 chr3:160939853 NMD3 -0.79 -18.75 -0.6 7.85e-63 Parkinson's disease; BRCA cis rs713587 0.806 rs6737082 chr2:25138040 A/C cg04586622 chr2:25135609 ADCY3 0.39 9.63 0.36 1.35e-20 Body mass index in non-asthmatics; BRCA cis rs3925075 0.833 rs11641202 chr16:31330161 A/G cg02846316 chr16:31340340 ITGAM 0.51 12.34 0.44 1.52e-31 IgA nephropathy; BRCA cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.4 11.32 0.41 3.45e-27 Monocyte percentage of white cells; BRCA cis rs17799476 0.938 rs72808770 chr2:46361322 G/A cg12428440 chr2:46370979 PRKCE 0.5 8.54 0.32 1e-16 Hemoglobin concentration;Hematocrit; BRCA trans rs7615952 1.000 rs7616044 chr3:125649354 G/C cg07211511 chr3:129823064 LOC729375 -1.06 -21.77 -0.65 4.72e-79 Blood pressure (smoking interaction); BRCA cis rs7582180 0.585 rs13031711 chr2:100939433 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA trans rs6089829 0.962 rs2277769 chr20:61666805 C/T cg15934090 chr1:100435551 SLC35A3 0.35 8.1 0.31 2.75e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg26314531 chr2:26401878 FAM59B 0.92 14.25 0.49 3.25e-40 Gut microbiome composition (summer); BRCA cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg15997130 chr1:24165203 NA -0.45 -11.65 -0.42 1.36e-28 Immature fraction of reticulocytes; BRCA cis rs6138458 1.000 rs6114988 chr20:24977586 C/T cg26195577 chr20:24973756 C20orf3 1.03 28.96 0.75 1.94e-118 Blood protein levels; BRCA cis rs1499972 0.941 rs62264816 chr3:117666232 C/G cg07612923 chr3:117604196 NA 0.6 8.2 0.31 1.35e-15 Schizophrenia; BRCA cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs7385804 0.761 rs1734908 chr7:100313768 G/T cg20848291 chr7:100343083 ZAN 0.37 8.33 0.31 4.83e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs453301 0.658 rs13271797 chr8:8885954 G/A cg06636001 chr8:8085503 FLJ10661 -0.48 -9.95 -0.37 8.92e-22 Joint mobility (Beighton score); BRCA cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg03354898 chr7:1950403 MAD1L1 -0.46 -9.2 -0.34 4.95e-19 Bipolar disorder and schizophrenia; BRCA cis rs2463822 1.000 rs11231050 chr11:62131660 C/G cg06239285 chr11:62104954 ASRGL1 -0.62 -9.32 -0.35 1.82e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg26384229 chr12:38710491 ALG10B 0.75 17.2 0.56 8.9e-55 Bladder cancer; BRCA cis rs769267 0.965 rs2074296 chr19:19373689 A/G cg03709012 chr19:19516395 GATAD2A 0.69 14.66 0.5 3.55e-42 Tonsillectomy; BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg24633833 chr3:10029261 TMEM111 0.41 7.83 0.3 2.03e-14 Alzheimer's disease; BRCA cis rs992157 1.000 rs13429408 chr2:219142860 C/A cg00012203 chr2:219082015 ARPC2 0.6 12.54 0.44 2.11e-32 Colorectal cancer; BRCA cis rs11098499 0.863 rs2306457 chr4:120472839 T/A cg09307838 chr4:120376055 NA 0.68 13.99 0.48 5.74e-39 Corneal astigmatism; BRCA cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg05072774 chr3:49840536 C3orf54 0.36 7.85 0.3 1.79e-14 Resting heart rate; BRCA cis rs17490626 0.568 rs12413529 chr10:71211644 G/T cg12610070 chr10:71211762 TSPAN15 -0.33 -11.77 -0.42 4.44e-29 Thrombosis; BRCA cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08109568 chr15:31115862 NA 0.52 13.36 0.47 4.58e-36 Huntington's disease progression; BRCA cis rs490234 0.586 rs3122934 chr9:128154100 C/G cg14078157 chr9:128172775 NA 0.35 7.86 0.3 1.7e-14 Mean arterial pressure; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg00814883 chr7:100076585 TSC22D4 -0.47 -10.51 -0.38 6e-24 Platelet count; BRCA cis rs7973719 0.833 rs7970916 chr12:7357746 T/C cg07052231 chr12:7363540 PEX5 0.36 8.17 0.31 1.66e-15 IgG glycosylation; BRCA cis rs2354432 0.607 rs894471 chr1:146687913 A/G cg25205988 chr1:146714368 CHD1L -0.78 -10.16 -0.37 1.39e-22 Mitochondrial DNA levels; BRCA cis rs2882667 0.690 rs9327829 chr5:138261671 A/G cg04439458 chr5:138467593 SIL1 0.33 8.24 0.31 9.82e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs11608355 0.515 rs6606727 chr12:109941450 T/A cg05360138 chr12:110035743 NA 0.74 13.68 0.48 1.56e-37 Neuroticism; BRCA cis rs1707322 0.691 rs12031182 chr1:46220999 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.17 0.43 8.34e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg22963979 chr7:1858916 MAD1L1 -0.47 -9.4 -0.35 9.23e-20 Bipolar disorder and schizophrenia; BRCA cis rs9649213 0.593 rs6465667 chr7:97957885 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.39 0.44 9.53e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs12986413 0.651 rs2238609 chr19:2146629 C/T cg09261902 chr19:2140048 AP3D1 0.43 11.07 0.4 3.52e-26 Height; BRCA cis rs6456156 0.586 rs911632 chr6:167471461 T/C cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs7727544 0.526 rs4705908 chr5:131347520 G/A cg14196790 chr5:131705035 SLC22A5 0.33 8.3 0.31 6.4e-16 Blood metabolite levels; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.66 13.42 0.47 2.36e-36 Lymphocyte counts; BRCA cis rs10463316 0.817 rs13359941 chr5:150802118 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.62 -0.32 5.19e-17 Metabolite levels (Pyroglutamine); BRCA cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg24549020 chr5:56110836 MAP3K1 0.66 13.27 0.46 1.13e-35 Initial pursuit acceleration; BRCA cis rs870825 0.616 rs1401361 chr4:185643742 G/C cg04058563 chr4:185651563 MLF1IP 0.76 17.01 0.56 8.69e-54 Blood protein levels; BRCA cis rs6460942 1.000 rs73053531 chr7:12317474 T/C cg06484146 chr7:12443880 VWDE -0.63 -8.62 -0.32 5.18e-17 Coronary artery disease; BRCA trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.12 0.34 9.85e-19 Morning vs. evening chronotype; BRCA cis rs8103278 1.000 rs11671524 chr19:46327166 G/A cg12641515 chr19:46296257 DMWD -0.53 -11.54 -0.42 3.92e-28 Coronary artery disease; BRCA trans rs9951602 0.512 rs9955812 chr18:76650954 T/A cg02800362 chr5:177631904 HNRNPAB 0.77 18.01 0.58 5.8e-59 Obesity-related traits; BRCA cis rs965469 1.000 rs6037579 chr20:3347980 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -10.57 -0.39 3.46e-24 IFN-related cytopenia; BRCA cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg26597838 chr10:835615 NA 1.07 17.92 0.58 1.78e-58 Eosinophil percentage of granulocytes; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg22907277 chr7:1156413 C7orf50 0.46 10.47 0.38 8.61e-24 Longevity;Endometriosis; BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg12311346 chr5:56204834 C5orf35 -0.78 -14.91 -0.51 2.36e-43 Initial pursuit acceleration; BRCA cis rs13315871 0.929 rs9871725 chr3:58292525 T/G cg20936604 chr3:58311152 NA -0.67 -8.64 -0.32 4.35e-17 Cholesterol, total; BRCA trans rs9325144 0.534 rs1843866 chr12:38703160 G/T cg23762105 chr12:34175262 ALG10 -0.36 -9.08 -0.34 1.36e-18 Morning vs. evening chronotype; BRCA cis rs9811920 0.690 rs7623587 chr3:99906751 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 8.88 0.33 6.54e-18 Axial length; BRCA trans rs8073060 0.586 rs7213804 chr17:34010931 T/G cg19694781 chr19:47549865 TMEM160 -1.06 -21.56 -0.65 7.18e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs965469 1.000 rs2236106 chr20:3278410 A/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.24 -0.38 6.8e-23 IFN-related cytopenia; BRCA trans rs2562456 0.917 rs10420016 chr19:21688602 C/G cg25042112 chr7:64838748 ZNF92 0.45 8.36 0.31 3.91e-16 Pain; BRCA cis rs1971762 0.583 rs10876485 chr12:54087648 C/T cg23533419 chr12:54090519 NA 0.31 7.86 0.3 1.63e-14 Height; BRCA cis rs12155623 0.592 rs12682003 chr8:49865454 G/T cg00325661 chr8:49890786 NA 0.34 8.96 0.33 3.58e-18 Sudden cardiac arrest; BRCA cis rs4727027 0.704 rs4727031 chr7:148908305 T/C cg23583168 chr7:148888333 NA -0.89 -23.38 -0.68 7.44e-88 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs17685 0.712 rs1637049 chr7:75729975 C/G cg19862616 chr7:65841803 NCRNA00174 0.85 27.57 0.74 7.42e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg05340658 chr4:99064831 C4orf37 0.7 17.28 0.56 3.4e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs8077889 0.917 rs1859048 chr17:41892039 A/C cg26893861 chr17:41843967 DUSP3 -0.63 -11.9 -0.43 1.28e-29 Triglycerides; BRCA cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg20933634 chr6:27740509 NA 0.48 9.61 0.36 1.64e-20 Parkinson's disease; BRCA cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg02353165 chr6:42928485 GNMT -0.72 -13.29 -0.47 9.38e-36 Blood protein levels; BRCA cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg24747557 chr10:131355152 MGMT -0.36 -8.81 -0.33 1.19e-17 Response to temozolomide; BRCA cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg25358565 chr5:93447407 FAM172A 1.19 18.71 0.59 1.27e-62 Diabetic retinopathy; BRCA cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -11.35 -0.41 2.48e-27 Chronic sinus infection; BRCA cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg23719950 chr11:63933701 MACROD1 -0.59 -9.71 -0.36 6.84e-21 Mean platelet volume; BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg24549020 chr5:56110836 MAP3K1 0.59 12.16 0.43 9.22e-31 Initial pursuit acceleration; BRCA cis rs2243480 1.000 rs316326 chr7:65609453 T/C cg18252515 chr7:66147081 NA -1.04 -15.46 -0.52 5.05e-46 Diabetic kidney disease; BRCA cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg08048268 chr3:133502702 NA -0.42 -10.77 -0.39 5.91e-25 Iron status biomarkers; BRCA cis rs10782582 0.593 rs11801414 chr1:76124517 G/A cg03433033 chr1:76189801 ACADM -0.47 -9.86 -0.36 1.94e-21 Daytime sleep phenotypes; BRCA cis rs3917254 0.570 rs2310187 chr2:102750428 G/T cg22835712 chr2:102737379 NA -0.58 -10.62 -0.39 2.31e-24 Blood protein levels; BRCA cis rs2032447 0.670 rs198852 chr6:26104448 A/G cg12310025 chr6:25882481 NA 0.41 9.36 0.35 1.34e-19 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs7772486 0.658 rs6570706 chr6:145962922 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.21 0.56 7.67e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -10.99 -0.4 7.55e-26 IgG glycosylation; BRCA cis rs13102973 0.965 rs7656209 chr4:135875550 G/A cg14419869 chr4:135874104 NA 0.51 10.88 0.4 2.04e-25 Subjective well-being; BRCA trans rs7829975 0.593 rs2921077 chr8:8304502 C/T cg16141378 chr3:129829833 LOC729375 -0.39 -10.09 -0.37 2.67e-22 Mood instability; BRCA cis rs757278 0.608 rs6977789 chr7:117342771 A/G cg10524701 chr7:117356490 CTTNBP2 0.42 7.81 0.3 2.32e-14 Response to methotrexate in juvenile idiopathic arthritis; BRCA trans rs7786808 0.741 rs4909222 chr7:158228095 C/T cg02030672 chr11:45687055 CHST1 -0.38 -7.98 -0.3 6.81e-15 Obesity-related traits; BRCA trans rs2562456 0.833 rs2681388 chr19:21732253 G/C cg25042112 chr7:64838748 ZNF92 -0.45 -8.34 -0.31 4.45e-16 Pain; BRCA cis rs713587 0.520 rs483428 chr2:25305136 A/G cg01884057 chr2:25150051 NA 0.32 8.18 0.31 1.54e-15 Body mass index in non-asthmatics; BRCA cis rs12579753 0.917 rs11115058 chr12:82263427 T/C cg07988820 chr12:82153109 PPFIA2 -0.48 -8.0 -0.3 5.67e-15 Resting heart rate; BRCA trans rs7200543 1.000 rs16966947 chr16:15141045 T/C cg24683922 chr1:11983373 KIAA2013 -0.35 -7.89 -0.3 1.29e-14 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs910316 0.967 rs175505 chr14:75529619 C/T cg23033748 chr14:75592666 NEK9 -0.41 -9.99 -0.37 6.3e-22 Height; BRCA cis rs1008375 0.806 rs13139898 chr4:17706928 T/G cg02297831 chr4:17616191 MED28 -0.35 -7.9 -0.3 1.26e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7707921 0.881 rs112413913 chr5:81359709 A/G cg15871215 chr5:81402204 ATG10 -0.39 -8.2 -0.31 1.33e-15 Breast cancer; BRCA cis rs12142240 0.698 rs72677589 chr1:46817770 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.19 -0.34 5.31e-19 Menopause (age at onset); BRCA cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg17211192 chr8:82754475 SNX16 0.6 11.81 0.42 2.98e-29 Diastolic blood pressure; BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11161846 chr1:160990452 F11R -0.54 -13.22 -0.46 1.86e-35 Granulocyte percentage of myeloid white cells; BRCA trans rs60843830 1.000 rs36216559 chr2:262335 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.66 14.5 0.5 2.19e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4481887 1.000 rs10888358 chr1:248471467 C/A cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.9e-18 Common traits (Other); BRCA cis rs2404602 0.735 rs1607017 chr15:76726465 G/T cg23625390 chr15:77176239 SCAPER -0.5 -11.84 -0.42 2.14e-29 Blood metabolite levels; BRCA cis rs514406 0.505 rs835609 chr1:53170494 T/C cg16325326 chr1:53192061 ZYG11B 0.86 25.41 0.71 5.81e-99 Monocyte count; BRCA cis rs477895 0.713 rs7952318 chr11:63961242 G/A cg18225595 chr11:63971243 STIP1 0.52 9.85 0.36 2.05e-21 Mean platelet volume; BRCA cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.82 0.33 1.1e-17 Motion sickness; BRCA trans rs11098499 0.657 rs9996569 chr4:120299004 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs10791323 0.593 rs10791329 chr11:133716356 T/C cg06766960 chr11:133703094 NA -0.62 -13.06 -0.46 1.02e-34 Childhood ear infection; BRCA cis rs1707322 0.928 rs6681068 chr1:46398382 G/A cg03146154 chr1:46216737 IPP 0.46 10.2 0.37 9.95e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11191205 0.865 rs11191161 chr10:103726528 C/T cg15320455 chr10:103880129 LDB1 -0.57 -9.03 -0.34 2.02e-18 Intelligence (multi-trait analysis); BRCA cis rs7264396 0.563 rs6060560 chr20:34278890 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.83 -0.39 3.28e-25 Total cholesterol levels; BRCA cis rs74417235 0.684 rs7723610 chr5:154053349 A/C cg08754654 chr5:154026448 NA 0.4 9.78 0.36 3.76e-21 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs2242116 0.592 rs6442039 chr3:46960797 C/G cg27129171 chr3:47204927 SETD2 0.6 11.15 0.4 1.72e-26 Birth weight; BRCA cis rs3806843 0.966 rs4141841 chr5:140203432 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.97 -0.37 7.54e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg20476274 chr7:133979776 SLC35B4 0.63 17.86 0.58 3.52e-58 Mean platelet volume; BRCA cis rs2742234 0.541 rs1317214 chr10:43733531 C/G cg15436174 chr10:43711423 RASGEF1A 0.52 10.42 0.38 1.32e-23 Hirschsprung disease; BRCA cis rs701145 0.537 rs1713855 chr3:153847833 T/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs1153858 1.000 rs1980288 chr15:45620612 T/C cg21132104 chr15:45694354 SPATA5L1 0.74 15.79 0.53 1.16e-47 Homoarginine levels; BRCA cis rs1005277 0.522 rs289645 chr10:37943642 T/C cg00409905 chr10:38381863 ZNF37A -0.43 -9.04 -0.34 1.91e-18 Extrinsic epigenetic age acceleration; BRCA cis rs681343 1.000 rs516246 chr19:49206172 C/T cg21064579 chr19:49206444 FUT2 0.38 9.42 0.35 8.19e-20 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs72781680 0.898 rs72798049 chr2:23958002 C/G cg20701182 chr2:24300061 SF3B14 0.56 8.63 0.32 4.99e-17 Lymphocyte counts; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07092213 chr7:1199455 ZFAND2A -0.4 -7.82 -0.3 2.13e-14 Longevity;Endometriosis; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg03188948 chr7:1209495 NA 0.82 11.39 0.41 1.8e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12995491 0.569 rs6724281 chr2:88529531 T/G cg07952391 chr2:88470173 THNSL2 -0.52 -10.09 -0.37 2.51e-22 Response to metformin (IC50); BRCA cis rs9814567 0.896 rs1357764 chr3:134344928 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 17.85 0.58 3.83e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.710 rs6851130 chr4:120133712 G/A cg25214090 chr10:38739885 LOC399744 -0.46 -9.84 -0.36 2.35e-21 Corneal astigmatism; BRCA cis rs1371614 0.635 rs34803465 chr2:27138285 G/A cg12368169 chr2:27073192 DPYSL5 -0.31 -9.15 -0.34 7.45e-19 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs8114671 0.562 rs6088646 chr20:33505937 T/C cg07148914 chr20:33460835 GGT7 0.38 8.57 0.32 7.57e-17 Height; BRCA cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg15145296 chr3:125709740 NA -0.53 -8.38 -0.31 3.25e-16 Blood pressure (smoking interaction); BRCA cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg08213375 chr14:104286397 PPP1R13B 0.63 18.06 0.58 3.25e-59 Schizophrenia; BRCA cis rs6724607 1.000 rs4321393 chr2:191452899 G/T cg20818283 chr2:191399100 TMEM194B 0.43 9.72 0.36 6.35e-21 Pulse pressure; BRCA cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA cis rs4805272 0.512 rs8106166 chr19:29339578 A/G cg12756686 chr19:29218302 NA -0.47 -8.5 -0.32 1.36e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs68170813 0.523 rs7781947 chr7:106902219 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.48 -0.32 1.59e-16 Coronary artery disease; BRCA cis rs870825 0.616 rs2141257 chr4:185609463 C/T cg04058563 chr4:185651563 MLF1IP -0.82 -15.53 -0.52 2.11e-46 Blood protein levels; BRCA trans rs7824557 0.836 rs1435278 chr8:11123029 G/T cg06636001 chr8:8085503 FLJ10661 -0.56 -10.75 -0.39 6.9e-25 Retinal vascular caliber; BRCA cis rs17685 0.712 rs7778735 chr7:75770237 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10492096 1.000 rs11064218 chr12:6586261 C/T cg13857086 chr12:6580257 VAMP1 0.45 8.63 0.32 4.81e-17 Hip geometry; BRCA cis rs4819052 0.851 rs9977178 chr21:46664531 G/T cg11663144 chr21:46675770 NA -0.6 -13.94 -0.48 9.31e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg08885076 chr2:99613938 TSGA10 0.46 10.93 0.4 1.36e-25 Chronic sinus infection; BRCA cis rs8077889 0.672 rs1234612 chr17:41840802 A/G cg26893861 chr17:41843967 DUSP3 0.88 22.21 0.66 2.09e-81 Triglycerides; BRCA cis rs7267979 0.932 rs928121 chr20:25534818 A/G cg08601574 chr20:25228251 PYGB 0.34 8.23 0.31 1.02e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12477438 0.834 rs11903311 chr2:99701807 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.6 -13.35 -0.47 5.07e-36 Chronic sinus infection; BRCA cis rs13118159 0.934 rs2878608 chr4:1354286 C/G cg16405210 chr4:1374714 KIAA1530 -0.46 -11.09 -0.4 2.88e-26 Longevity; BRCA cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg16339924 chr4:17578868 LAP3 0.66 16.95 0.56 1.68e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9394841 0.692 rs9381094 chr6:41800629 T/C cg08135965 chr6:41755394 TOMM6 0.47 7.82 0.3 2.15e-14 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs6446731 0.517 rs2798221 chr4:3270488 T/C cg08886695 chr4:3369023 RGS12 0.37 9.68 0.36 9.04e-21 Mean platelet volume; BRCA trans rs17685 0.712 rs10235738 chr7:75773460 G/A cg19862616 chr7:65841803 NCRNA00174 0.82 26.58 0.72 2.01e-105 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10751667 0.643 rs7394524 chr11:933865 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.47e-49 Alzheimer's disease (late onset); BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg09436375 chr6:42928200 GNMT 0.31 11.28 0.41 4.86e-27 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs597539 0.652 rs646586 chr11:68681653 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.73 -17.26 -0.56 4.2e-55 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs208520 0.837 rs208467 chr6:66914837 T/C cg07460842 chr6:66804631 NA -0.89 -15.72 -0.53 2.64e-47 Exhaled nitric oxide output; BRCA cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg10523679 chr1:76189770 ACADM 0.77 18.74 0.6 8.51e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg10729496 chr3:10149963 C3orf24 0.47 7.84 0.3 1.9e-14 Alzheimer's disease; BRCA cis rs11662586 0.517 rs7228070 chr18:77698967 C/T cg20368463 chr18:77673604 PQLC1 0.46 11.64 0.42 1.63e-28 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs9814567 0.806 rs9857242 chr3:134316378 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.2 0.31 1.35e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7772486 0.875 rs2474353 chr6:146323883 G/A cg23711669 chr6:146136114 FBXO30 0.73 16.71 0.55 2.91e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs208520 0.690 rs851468 chr6:66825875 G/A cg07460842 chr6:66804631 NA -1.01 -19.81 -0.62 1.93e-68 Exhaled nitric oxide output; BRCA cis rs17376456 1.000 rs61132622 chr5:93539684 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 7.87 0.3 1.53e-14 Diabetic retinopathy; BRCA trans rs4714291 0.832 rs3008839 chr6:40052660 G/A cg02267698 chr19:7991119 CTXN1 -0.44 -8.9 -0.33 5.9e-18 Strep throat; BRCA cis rs6088580 0.524 rs6088568 chr20:33265971 A/C cg24642439 chr20:33292090 TP53INP2 -0.42 -8.69 -0.33 2.99e-17 Glomerular filtration rate (creatinine); BRCA trans rs4596713 0.538 rs11145484 chr9:71769857 G/C cg16512924 chr15:28394682 HERC2 0.44 10.45 0.38 1.04e-23 Headache; BRCA cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg12927641 chr6:109611667 NA -0.42 -10.95 -0.4 1.11e-25 Reticulocyte fraction of red cells; BRCA cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.74 10.14 0.37 1.73e-22 Initial pursuit acceleration; BRCA cis rs965469 0.857 rs6037523 chr20:3249463 A/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.72 -0.33 2.4e-17 IFN-related cytopenia; BRCA cis rs7737355 0.947 rs251014 chr5:131029463 A/G cg06307176 chr5:131281290 NA 0.52 10.22 0.37 8.02e-23 Life satisfaction; BRCA cis rs10504229 0.595 rs36081958 chr8:58117505 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs79976124 0.879 rs17511467 chr6:66627293 T/C cg07460842 chr6:66804631 NA 0.6 10.2 0.37 1.01e-22 Type 2 diabetes; BRCA cis rs614226 1.000 rs1167725 chr12:120968559 A/T cg01236616 chr12:121019343 POP5 1.24 27.07 0.73 4.13e-108 Type 1 diabetes nephropathy; BRCA cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg05025164 chr4:1340916 KIAA1530 0.38 8.18 0.31 1.58e-15 Longevity; BRCA cis rs7666738 0.830 rs6831588 chr4:98977356 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg11062466 chr8:58055876 NA 0.41 7.92 0.3 1.04e-14 Developmental language disorder (linguistic errors); BRCA trans rs7824557 0.767 rs2164273 chr8:11168499 A/G cg06636001 chr8:8085503 FLJ10661 0.52 10.25 0.38 6.3e-23 Retinal vascular caliber; BRCA cis rs28595532 1.000 rs28595532 chr4:119716950 A/C cg21605333 chr4:119757512 SEC24D 1.23 12.24 0.44 4.48e-31 Cannabis dependence symptom count; BRCA cis rs7586879 0.639 rs13407913 chr2:25097644 A/G cg01884057 chr2:25150051 NA 0.31 8.09 0.3 3.08e-15 Body mass index; BRCA cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg24110177 chr3:50126178 RBM5 -0.52 -15.02 -0.51 6.94e-44 Body mass index; BRCA cis rs6456156 0.586 rs13195158 chr6:167481392 G/A cg07741184 chr6:167504864 NA 0.33 9.9 0.36 1.41e-21 Primary biliary cholangitis; BRCA cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.84 0.42 2.3e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6500602 0.674 rs7191664 chr16:4541924 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.4 8.5 0.32 1.32e-16 Schizophrenia; BRCA cis rs7666738 0.791 rs7665273 chr4:98997413 C/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.777 rs8189597 chr12:38307739 G/C cg26384229 chr12:38710491 ALG10B -0.74 -16.88 -0.56 3.78e-53 Bladder cancer; BRCA cis rs427394 0.802 rs274720 chr5:6719933 A/G cg10857441 chr5:6722123 POLS -0.33 -10.96 -0.4 1.03e-25 Menopause (age at onset); BRCA cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs597539 0.652 rs544370 chr11:68653232 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 19.11 0.6 9.47e-65 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg04025307 chr7:1156635 C7orf50 0.72 18.68 0.59 1.78e-62 Longevity;Endometriosis; BRCA cis rs12410462 0.681 rs76705164 chr1:227615570 G/A cg04117972 chr1:227635322 NA 0.58 9.97 0.37 7.71e-22 Major depressive disorder; BRCA cis rs12200560 0.505 rs984519 chr6:97076223 A/G cg06623918 chr6:96969491 KIAA0776 -0.51 -12.39 -0.44 9.32e-32 Coronary heart disease; BRCA cis rs4268898 0.795 rs12470303 chr2:24619883 C/T cg06627628 chr2:24431161 ITSN2 -0.41 -8.56 -0.32 8.32e-17 Asthma; BRCA cis rs7617773 0.780 rs34946886 chr3:48338487 A/G cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs17685 0.725 rs1044483 chr7:75659815 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.4 9.03 0.34 2.05e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg13770153 chr20:60521292 NA 0.58 12.47 0.44 4.18e-32 Body mass index; BRCA cis rs9837602 0.935 rs9860290 chr3:99839106 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.56 9.69 0.36 8.35e-21 Breast cancer; BRCA cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg17143192 chr8:8559678 CLDN23 0.56 10.87 0.4 2.2e-25 Obesity-related traits; BRCA trans rs4714291 0.802 rs911818 chr6:39988816 C/A cg02267698 chr19:7991119 CTXN1 -0.46 -9.43 -0.35 7.69e-20 Strep throat; BRCA cis rs7927771 0.507 rs10838759 chr11:47785347 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.54 0.35 2.88e-20 Subjective well-being; BRCA cis rs10193935 0.579 rs62142594 chr2:42524531 G/A cg27598129 chr2:42591480 NA -1.07 -11.92 -0.43 1.01e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs6598955 0.671 rs12068212 chr1:26612935 C/T cg00852783 chr1:26633632 UBXN11 -0.47 -8.52 -0.32 1.15e-16 Obesity-related traits; BRCA cis rs12142240 0.698 rs41294456 chr1:46809782 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA trans rs637571 0.522 rs491973 chr11:65727301 A/G cg17712092 chr4:129076599 LARP1B 0.54 13.09 0.46 7.47e-35 Eosinophil percentage of white cells; BRCA trans rs1814175 0.935 rs11040465 chr11:49689323 C/T cg11707556 chr5:10655725 ANKRD33B -0.45 -11.39 -0.41 1.77e-27 Height; BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg01262667 chr19:19385393 TM6SF2 -0.42 -10.95 -0.4 1.04e-25 Tonsillectomy; BRCA trans rs853679 0.607 rs67040724 chr6:27905509 T/C cg01620082 chr3:125678407 NA -0.99 -11.42 -0.41 1.23e-27 Depression; BRCA cis rs7586673 0.964 rs34444368 chr2:161954217 G/A cg21518248 chr2:162101506 NA 0.48 9.69 0.36 7.99e-21 Intelligence (multi-trait analysis); BRCA cis rs11997175 0.545 rs7818001 chr8:33807682 G/T ch.8.33884649F chr8:33765107 NA 0.36 8.52 0.32 1.15e-16 Body mass index; BRCA cis rs40363 0.723 rs8060367 chr16:3537919 C/A cg22508957 chr16:3507546 NAT15 -0.58 -8.77 -0.33 1.65e-17 Tuberculosis; BRCA cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg22875332 chr1:76189707 ACADM -0.69 -15.05 -0.51 4.97e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.87 0.36 1.72e-21 Lung cancer in ever smokers; BRCA cis rs1420338 0.869 rs1362452 chr7:34170519 G/A cg01275685 chr7:34179230 BMPER -0.5 -11.29 -0.41 4.42e-27 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7772486 0.875 rs10872583 chr6:146396699 G/T cg23711669 chr6:146136114 FBXO30 -0.71 -16.08 -0.54 4.02e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9486719 0.843 rs1009597 chr6:96843540 A/T cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg14019146 chr3:50243930 SLC38A3 0.37 9.1 0.34 1.12e-18 Menarche (age at onset); BRCA cis rs9837602 0.529 rs793494 chr3:99508768 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 7.93 0.3 9.65e-15 Breast cancer; BRCA cis rs11984145 1.000 rs28680843 chr7:38869571 C/T cg19327137 chr7:38886074 VPS41 0.49 8.55 0.32 9.39e-17 Cognitive performance; BRCA cis rs2153535 0.580 rs9406171 chr6:8515362 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.88e-41 Motion sickness; BRCA cis rs62229266 0.804 rs2835231 chr21:37390598 C/T cg12218747 chr21:37451666 NA -0.34 -7.85 -0.3 1.8e-14 Mitral valve prolapse; BRCA cis rs10751667 1.000 rs11246359 chr11:967943 T/C cg01483505 chr11:975446 AP2A2 0.34 9.28 0.34 2.49e-19 Alzheimer's disease (late onset); BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.35 0.35 1.49e-19 Tonsillectomy; BRCA trans rs970548 0.738 rs61854124 chr10:46077158 T/C cg20477318 chr10:51623047 TIMM23 0.44 7.91 0.3 1.14e-14 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; BRCA cis rs7412746 0.611 rs111842513 chr1:150712926 G/A cg04414720 chr1:150670196 GOLPH3L 0.36 8.21 0.31 1.27e-15 Melanoma; BRCA cis rs965469 1.000 rs6051838 chr20:3389012 A/C cg25506879 chr20:3388711 C20orf194 -0.54 -10.81 -0.39 4.03e-25 IFN-related cytopenia; BRCA cis rs2370759 1.000 rs16933177 chr10:32565705 G/A cg01819863 chr10:32635814 EPC1 1.15 20.1 0.62 5.42e-70 Sexual dysfunction (female); BRCA cis rs6484504 0.625 rs796341 chr11:31414151 G/A cg06552810 chr11:31128660 NA 0.39 8.52 0.32 1.15e-16 Red blood cell count; BRCA cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs495337 1.000 rs6067293 chr20:48581741 T/C cg17835207 chr20:48524531 SPATA2 -0.61 -14.07 -0.49 2.21e-39 Psoriasis; BRCA cis rs3733585 0.699 rs4588456 chr4:9963895 A/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs514406 0.679 rs541852 chr1:53256834 A/G cg25767906 chr1:53392781 SCP2 0.52 11.09 0.4 3.01e-26 Monocyte count; BRCA cis rs4805272 0.512 rs7245724 chr19:29341679 C/T cg12756686 chr19:29218302 NA 0.47 8.32 0.31 5.17e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs6842047 1.000 rs1511800 chr4:187135556 C/T cg23442198 chr4:187126114 CYP4V2 0.61 8.41 0.32 2.69e-16 Blood protein levels; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg16145915 chr7:1198662 ZFAND2A -0.64 -15.85 -0.53 5.85e-48 Longevity;Endometriosis; BRCA cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg05347473 chr6:146136440 FBXO30 0.62 12.07 0.43 2.26e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.698 rs12385697 chr1:46818898 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 9.02e-21 Menopause (age at onset); BRCA cis rs2012796 0.957 rs7151434 chr14:81819468 A/G cg02996355 chr14:81879375 NA 0.43 8.61 0.32 5.54e-17 Night sleep phenotypes; BRCA cis rs2153535 0.580 rs1335628 chr6:8491742 A/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg26597838 chr10:835615 NA 1.01 15.79 0.53 1.1e-47 Eosinophil percentage of granulocytes; BRCA cis rs6964587 1.000 rs6952671 chr7:91597934 C/A cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.72e-31 Breast cancer; BRCA cis rs2762353 0.595 rs12207270 chr6:25751721 A/G cg12310025 chr6:25882481 NA -0.7 -17.53 -0.57 1.72e-56 Blood metabolite levels; BRCA cis rs12971120 0.947 rs34676212 chr18:72170006 A/G cg27029518 chr18:72166324 CNDP2 -0.31 -8.67 -0.32 3.67e-17 Refractive error; BRCA cis rs4689388 0.890 rs4481292 chr4:6298375 C/T cg00701064 chr4:6280414 WFS1 0.71 19.54 0.61 5.18e-67 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs965469 0.779 rs2236114 chr20:3296040 A/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.77 -0.33 1.66e-17 IFN-related cytopenia; BRCA cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg14440974 chr22:39074834 NA -0.39 -9.14 -0.34 8.25e-19 Menopause (age at onset); BRCA cis rs6964587 1.000 rs6953515 chr7:91658620 C/T cg01689657 chr7:91764605 CYP51A1 0.24 8.58 0.32 7.31e-17 Breast cancer; BRCA cis rs6570726 1.000 rs374464 chr6:145846679 A/C cg23711669 chr6:146136114 FBXO30 0.64 14.88 0.51 3.31e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA cis rs11252926 0.673 rs10795161 chr10:497748 G/T cg18196295 chr10:418757 DIP2C 0.45 10.59 0.39 3.09e-24 Psychosis in Alzheimer's disease; BRCA cis rs2239547 0.522 rs9846976 chr3:53007995 T/C cg11645453 chr3:52864694 ITIH4 0.42 10.6 0.39 2.68e-24 Schizophrenia; BRCA cis rs10789491 1.000 rs35861275 chr1:47171909 A/C cg15501359 chr1:47185051 KIAA0494 -0.65 -16.05 -0.54 5.82e-49 Response to hepatitis C treatment; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg23708337 chr7:1209742 NA 0.5 9.77 0.36 4.14e-21 Longevity;Endometriosis; BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg10729496 chr3:10149963 C3orf24 -0.46 -7.93 -0.3 9.74e-15 Alzheimer's disease; BRCA cis rs12474201 0.507 rs6714451 chr2:47017743 G/C cg06386533 chr2:46925753 SOCS5 0.39 7.87 0.3 1.47e-14 Height; BRCA cis rs9304742 0.962 rs12461796 chr19:53455088 T/A cg24044776 chr19:53454761 ZNF816A -0.41 -9.31 -0.35 2.09e-19 Psoriasis; BRCA cis rs3917254 0.596 rs13001315 chr2:102763210 G/A cg22835712 chr2:102737379 NA -0.52 -8.8 -0.33 1.27e-17 Blood protein levels; BRCA cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg16339924 chr4:17578868 LAP3 0.6 14.62 0.5 5.83e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8062405 1.000 rs56358680 chr16:28843118 A/G cg09754948 chr16:28834200 ATXN2L 0.46 9.18 0.34 6.07e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10752881 0.809 rs3738829 chr1:183113862 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.45 0.55 5.92e-51 Colorectal cancer; BRCA cis rs2427308 0.643 rs477859 chr20:60937597 A/G cg06026331 chr20:60912101 LAMA5 -0.54 -10.66 -0.39 1.57e-24 Colorectal cancer; BRCA trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.76e-30 Corneal astigmatism; BRCA cis rs1552244 1.000 rs9849434 chr3:10133710 A/G cg00166722 chr3:10149974 C3orf24 -0.61 -12.85 -0.45 8.82e-34 Alzheimer's disease; BRCA trans rs12310956 0.532 rs2087270 chr12:33850109 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.43 0.35 7.23e-20 Morning vs. evening chronotype; BRCA cis rs7523050 0.643 rs35438081 chr1:109402831 G/T cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg07395648 chr5:131743802 NA -0.36 -7.9 -0.3 1.2e-14 Breast cancer; BRCA cis rs477895 0.653 rs34089806 chr11:63887987 C/T cg04317338 chr11:64019027 PLCB3 0.53 9.25 0.34 3.32e-19 Mean platelet volume; BRCA cis rs9790314 0.936 rs7629987 chr3:161002023 A/C cg03342759 chr3:160939853 NMD3 -0.64 -13.48 -0.47 1.2e-36 Morning vs. evening chronotype; BRCA cis rs1707322 0.686 rs3014251 chr1:46077428 G/C cg03146154 chr1:46216737 IPP -0.51 -11.08 -0.4 3.11e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7208859 0.524 rs73988172 chr17:29086332 A/C cg19761014 chr17:28927070 LRRC37B2 0.49 7.93 0.3 9.65e-15 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7914558 1.000 rs10883826 chr10:104830819 A/G cg04362960 chr10:104952993 NT5C2 0.41 10.03 0.37 4.23e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs875971 0.862 rs11763189 chr7:65983529 G/A cg11764359 chr7:65958608 NA 0.78 17.51 0.57 2.41e-56 Aortic root size; BRCA cis rs873946 0.586 rs12770021 chr10:134562021 G/A cg18305652 chr10:134549665 INPP5A 0.49 11.42 0.41 1.28e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg26677194 chr12:130822605 PIWIL1 0.6 14.33 0.49 1.31e-40 Menopause (age at onset); BRCA cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.33 -9.93 -0.37 1.05e-21 Bipolar disorder; BRCA cis rs490234 0.783 rs10119855 chr9:128271123 A/T cg14078157 chr9:128172775 NA -0.48 -10.97 -0.4 8.85e-26 Mean arterial pressure; BRCA cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs514406 0.830 rs533935 chr1:53308807 T/C cg25767906 chr1:53392781 SCP2 -0.37 -8.54 -0.32 9.64e-17 Monocyte count; BRCA trans rs66887589 0.616 rs10032299 chr4:120206419 C/T cg25214090 chr10:38739885 LOC399744 0.37 8.52 0.32 1.19e-16 Diastolic blood pressure; BRCA cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg01028140 chr2:1542097 TPO -0.77 -15.31 -0.52 2.73e-45 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1865760 0.532 rs9295687 chr6:26082710 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA cis rs796364 0.813 rs7565417 chr2:201057491 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.46 8.26 0.31 8.51e-16 Schizophrenia; BRCA cis rs77861329 1.000 rs893056 chr3:52109564 G/A cg08692210 chr3:52188851 WDR51A 0.66 9.64 0.36 1.26e-20 Macrophage inflammatory protein 1b levels; BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg16606324 chr3:10149918 C3orf24 0.56 11.2 0.4 1.08e-26 Alzheimer's disease; BRCA cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg12756686 chr19:29218302 NA 0.58 11.74 0.42 6.06e-29 Methadone dose in opioid dependence; BRCA cis rs56399783 0.901 rs55767077 chr7:2774608 C/T cg23627948 chr7:2760692 NA 0.51 8.23 0.31 1.03e-15 Childhood ear infection; BRCA cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.45 0.76 4.5e-121 Cognitive function; BRCA cis rs2153535 0.580 rs7743418 chr6:8438128 A/C cg07606381 chr6:8435919 SLC35B3 0.66 14.56 0.5 1.08e-41 Motion sickness; BRCA cis rs4595586 0.545 rs2388179 chr12:39364036 T/A cg26384229 chr12:38710491 ALG10B 0.42 9.4 0.35 9.92e-20 Morning vs. evening chronotype; BRCA cis rs9393692 0.905 rs7769028 chr6:26267568 C/T cg05868516 chr6:26286170 HIST1H4H 0.49 10.88 0.4 2e-25 Educational attainment; BRCA cis rs7666738 0.830 rs28795113 chr4:98951331 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.75e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.962 rs1116450 chr20:61658210 T/C cg03213289 chr20:61660250 NA 0.61 15.72 0.53 2.47e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs7312933 0.703 rs11181378 chr12:42600658 T/C cg17420585 chr12:42539391 GXYLT1 -0.38 -8.06 -0.3 3.77e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg03477792 chr4:77819574 ANKRD56 0.66 15.8 0.53 9.93e-48 Emphysema distribution in smoking; BRCA cis rs7264396 0.690 rs2425178 chr20:34446395 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.45 -0.52 5.35e-46 Total cholesterol levels; BRCA cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg16339924 chr4:17578868 LAP3 0.57 14.01 0.48 4.4e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3812049 0.737 rs1112956 chr5:127433798 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.54 -10.13 -0.37 1.81e-22 Lymphocyte counts;Red cell distribution width; BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg12444411 chr7:2802554 GNA12 -0.36 -8.89 -0.33 6.21e-18 Height; BRCA cis rs12612619 0.579 rs4552148 chr2:27080513 A/T cg12368169 chr2:27073192 DPYSL5 -0.33 -10.16 -0.37 1.36e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs4642101 0.824 rs9820977 chr3:12842932 G/A cg24848339 chr3:12840334 CAND2 0.41 10.56 0.39 3.85e-24 QRS complex (12-leadsum); BRCA cis rs6580649 0.941 rs72644847 chr12:48516093 C/A cg24011408 chr12:48396354 COL2A1 -0.49 -7.93 -0.3 9.64e-15 Lung cancer; BRCA cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg11752832 chr7:134001865 SLC35B4 0.47 11.78 0.42 3.97e-29 Mean platelet volume; BRCA cis rs453301 0.658 rs6983877 chr8:8904639 T/C cg15556689 chr8:8085844 FLJ10661 -0.36 -9.69 -0.36 8.1e-21 Joint mobility (Beighton score); BRCA cis rs7914558 1.000 rs67908413 chr10:104764989 T/C cg04362960 chr10:104952993 NT5C2 0.42 10.22 0.37 8.37e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg25817165 chr18:72167213 CNDP2 -0.77 -19.64 -0.61 1.55e-67 Refractive error; BRCA cis rs896854 0.967 rs2879813 chr8:95960947 A/G cg13393036 chr8:95962371 TP53INP1 -0.34 -9.32 -0.35 1.91e-19 Type 2 diabetes; BRCA cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg04455712 chr21:45112962 RRP1B 0.38 9.68 0.36 9.36e-21 Mean corpuscular volume; BRCA cis rs873946 0.648 rs12771651 chr10:134554482 C/A cg13271783 chr10:134563150 INPP5A -0.5 -9.51 -0.35 3.8e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9462027 0.628 rs2814967 chr6:34712838 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.81 -0.3 2.37e-14 Systemic lupus erythematosus; BRCA cis rs7945705 0.875 rs11042059 chr11:8795080 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.5 10.46 0.38 9.94e-24 Hemoglobin concentration; BRCA trans rs7647973 0.593 rs7620848 chr3:49828021 G/C cg21659725 chr3:3221576 CRBN 0.48 8.7 0.33 2.83e-17 Menarche (age at onset); BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg03354898 chr7:1950403 MAD1L1 0.47 9.87 0.36 1.8e-21 Bipolar disorder and schizophrenia; BRCA cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.54 -11.79 -0.42 3.55e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs634534 0.563 rs470192 chr11:65724291 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 9.92 0.37 1.09e-21 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs57590327 0.503 rs12152272 chr3:81911684 G/A cg07356753 chr3:81810745 GBE1 -0.45 -10.51 -0.38 6.33e-24 Extraversion; BRCA cis rs933688 1.000 rs6867219 chr5:90718008 T/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.77 16.24 0.54 6.44e-50 Smoking behavior; BRCA cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg11890956 chr21:40555474 PSMG1 -0.84 -22.0 -0.66 2.88e-80 Cognitive function; BRCA cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg21132104 chr15:45694354 SPATA5L1 0.74 16.3 0.54 3.4e-50 Homoarginine levels; BRCA cis rs1005277 0.579 rs1780121 chr10:38529437 C/A cg25427524 chr10:38739819 LOC399744 -0.74 -18.27 -0.59 2.53e-60 Extrinsic epigenetic age acceleration; BRCA cis rs9296092 0.538 rs62405953 chr6:33524760 C/T cg13560919 chr6:33536144 NA -0.86 -18.74 -0.6 8.89e-63 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA trans rs9951602 0.512 rs8097996 chr18:76648035 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 17.82 0.58 6.06e-58 Obesity-related traits; BRCA cis rs7927592 0.871 rs11228284 chr11:68322767 A/T cg20283391 chr11:68216788 NA -0.47 -9.12 -0.34 9.66e-19 Total body bone mineral density; BRCA cis rs17092148 0.887 rs2068474 chr20:33231079 A/G cg16810054 chr20:33298113 TP53INP2 -0.47 -10.39 -0.38 1.73e-23 Neuroticism; BRCA trans rs2562456 0.833 rs2562507 chr19:21726337 C/T cg25042112 chr7:64838748 ZNF92 0.45 8.29 0.31 6.69e-16 Pain; BRCA cis rs2153535 0.580 rs7341206 chr6:8470489 T/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs10193935 0.901 rs72798529 chr2:42537471 C/T cg27598129 chr2:42591480 NA -0.95 -14.87 -0.51 3.75e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs10746514 0.804 rs1854822 chr1:232262270 G/C cg09506761 chr1:232265262 NA -0.42 -8.66 -0.32 3.86e-17 Response to statin therapy; BRCA cis rs7493 1.000 rs2299265 chr7:95048870 C/G cg19678392 chr7:94953810 PON1 -0.41 -8.6 -0.32 6.16e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4803468 0.967 rs11670583 chr19:41920440 A/T cg09537434 chr19:41945824 ATP5SL -0.99 -23.25 -0.68 4.24e-87 Height; BRCA cis rs7975161 0.671 rs4475991 chr12:104596756 A/G cg25273343 chr12:104657179 TXNRD1 0.38 9.15 0.34 7.33e-19 Toenail selenium levels; BRCA cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg11062466 chr8:58055876 NA 0.41 8.04 0.3 4.43e-15 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg22974920 chr21:40686053 BRWD1 -0.4 -8.77 -0.33 1.57e-17 Cognitive function; BRCA cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg12432903 chr7:1882776 MAD1L1 0.44 7.94 0.3 8.89e-15 Bipolar disorder; BRCA cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg20503657 chr10:835505 NA 1.06 18.21 0.58 5.52e-60 Eosinophil percentage of granulocytes; BRCA cis rs7301826 0.610 rs4759791 chr12:131296495 A/G cg11011512 chr12:131303247 STX2 0.51 13.62 0.47 3e-37 Plasma plasminogen activator levels; BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.79 -0.42 3.69e-29 Gut microbiome composition (summer); BRCA cis rs4595586 0.525 rs12812749 chr12:39363254 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.02 0.34 2.15e-18 Morning vs. evening chronotype; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.6 -12.71 -0.45 3.81e-33 Lymphocyte counts; BRCA cis rs4957048 0.891 rs11960196 chr5:568857 C/A cg09021430 chr5:549028 NA -0.64 -16.44 -0.55 6.66e-51 Ulcerative colitis; BRCA cis rs600806 0.683 rs10857788 chr1:110012289 G/A cg20591472 chr1:110008990 SYPL2 0.31 7.85 0.3 1.77e-14 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.63 0.45 8.45e-33 Platelet count; BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg04944784 chr2:26401820 FAM59B -0.74 -12.11 -0.43 1.62e-30 Gut microbiome composition (summer); BRCA cis rs7944584 0.655 rs11039183 chr11:47346940 G/A cg20307385 chr11:47447363 PSMC3 0.59 12.51 0.44 2.74e-32 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4363385 0.647 rs4845513 chr1:152998066 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.45 -0.32 1.9e-16 Inflammatory skin disease; BRCA cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg11752832 chr7:134001865 SLC35B4 0.52 11.95 0.43 7.31e-30 Mean platelet volume; BRCA cis rs7737355 1.000 rs76753180 chr5:130763701 A/T cg06307176 chr5:131281290 NA -0.51 -9.78 -0.36 3.71e-21 Life satisfaction; BRCA cis rs12618769 0.652 rs11537554 chr2:99216531 A/G cg10123293 chr2:99228465 UNC50 0.44 8.69 0.32 3.15e-17 Bipolar disorder; BRCA cis rs9287719 0.674 rs1387566 chr2:10828650 C/T cg02196655 chr2:10830764 NOL10 0.29 7.82 0.3 2.12e-14 Prostate cancer; BRCA cis rs7954584 0.567 rs1720037 chr12:122382229 G/T cg13699009 chr12:122356056 WDR66 -0.37 -8.47 -0.32 1.68e-16 Mean corpuscular volume; BRCA cis rs6840258 1.000 rs72667753 chr4:87941012 C/T cg08197287 chr4:87952173 AFF1 -0.42 -8.31 -0.31 5.54e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg08045932 chr20:61659980 NA 0.49 11.17 0.4 1.35e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg13736514 chr6:26305472 NA -0.35 -11.91 -0.43 1.16e-29 Educational attainment; BRCA cis rs2204008 0.782 rs117824012 chr12:38215517 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.1 0.37 2.42e-22 Bladder cancer; BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg09060608 chr5:178986726 RUFY1 0.47 11.3 0.41 4.12e-27 Lung cancer; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 19.98 0.62 2.34e-69 Platelet count; BRCA cis rs6540559 1.000 rs742215 chr1:209961023 A/T cg21951975 chr1:209979733 IRF6 0.38 8.96 0.33 3.49e-18 Cleft lip with or without cleft palate; BRCA cis rs12477438 0.765 rs1115756 chr2:99659845 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.55 -0.52 1.7e-46 Chronic sinus infection; BRCA cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs909002 0.849 rs2271933 chr1:32092525 C/T cg13919466 chr1:32135498 COL16A1 0.27 9.46 0.35 5.88e-20 Intelligence (multi-trait analysis); BRCA cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg22862634 chr11:62369728 EML3;MTA2 0.57 13.62 0.47 2.81e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs7824557 0.767 rs11250127 chr8:11170209 G/A cg06636001 chr8:8085503 FLJ10661 0.54 10.18 0.37 1.21e-22 Retinal vascular caliber; BRCA cis rs769267 0.631 rs7252981 chr19:19692579 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.43 -8.12 -0.31 2.38e-15 Tonsillectomy; BRCA cis rs10206020 0.797 rs72778008 chr2:1573182 T/G cg26248373 chr2:1572462 NA -0.65 -15.81 -0.53 9.41e-48 IgG glycosylation; BRCA cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg26384229 chr12:38710491 ALG10B 0.67 15.12 0.51 2.21e-44 Morning vs. evening chronotype; BRCA cis rs897984 0.683 rs8050330 chr16:30824970 C/T cg00531865 chr16:30841666 NA -0.58 -14.88 -0.51 3.26e-43 Dementia with Lewy bodies; BRCA cis rs4074536 0.740 rs11578967 chr1:116301670 T/G cg21648376 chr1:116311395 CASQ2 -0.46 -8.18 -0.31 1.58e-15 QRS duration; BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg04267008 chr7:1944627 MAD1L1 0.4 8.94 0.33 4.06e-18 Bipolar disorder and schizophrenia; BRCA cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg16339924 chr4:17578868 LAP3 -0.62 -15.27 -0.52 4.02e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.73 16.4 0.54 9.88e-51 Lymphocyte counts; BRCA cis rs1580019 0.961 rs11768506 chr7:32494788 A/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.5 0.32 1.32e-16 Cognitive ability; BRCA cis rs7666738 0.830 rs13148324 chr4:98833616 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.69 0.5 2.65e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs10493773 0.775 rs12564080 chr1:86196586 A/C cg17807903 chr1:86174739 ZNHIT6 -0.47 -10.93 -0.4 1.36e-25 Urate levels in overweight individuals; BRCA trans rs61931739 0.635 rs1825746 chr12:33939984 C/T cg26384229 chr12:38710491 ALG10B 0.4 9.0 0.34 2.52e-18 Morning vs. evening chronotype; BRCA trans rs9291683 0.620 rs4383618 chr4:10125151 T/C cg26043149 chr18:55253948 FECH -0.4 -8.85 -0.33 8.36e-18 Bone mineral density; BRCA cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg26818010 chr10:134567672 INPP5A -0.77 -15.68 -0.53 3.83e-47 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 9.7 0.36 7.5e-21 Personality dimensions; BRCA cis rs4803468 1.000 rs11670668 chr19:41920454 G/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.25 -0.68 4.24e-87 Height; BRCA cis rs853679 0.517 rs12174753 chr6:28042465 C/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.15e-15 Depression; BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg04944784 chr2:26401820 FAM59B -1.0 -16.79 -0.55 1.16e-52 Gut microbiome composition (summer); BRCA cis rs495337 0.721 rs554263 chr20:48513893 G/C cg17835207 chr20:48524531 SPATA2 -0.68 -16.2 -0.54 1.08e-49 Psoriasis; BRCA cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg08885076 chr2:99613938 TSGA10 0.46 10.69 0.39 1.19e-24 Chronic sinus infection; BRCA cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg02297831 chr4:17616191 MED28 0.36 8.43 0.32 2.24e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11105298 0.891 rs10858865 chr12:89846476 G/A cg00757033 chr12:89920650 WDR51B 0.53 10.74 0.39 7.86e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs782590 0.556 rs782579 chr2:55917604 A/G cg18811423 chr2:55921094 PNPT1 0.69 22.01 0.66 2.57e-80 Metabolic syndrome; BRCA cis rs2625529 0.590 rs2856929 chr15:72496762 T/C cg16672083 chr15:72433130 SENP8 -0.82 -17.26 -0.56 4.5e-55 Red blood cell count; BRCA cis rs9859260 0.744 rs492288 chr3:195784210 C/T cg12923728 chr3:195709715 SDHAP1 0.38 7.83 0.3 2.01e-14 Mean corpuscular volume; BRCA trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg03929089 chr4:120376271 NA -0.81 -18.81 -0.6 3.73e-63 Height; BRCA cis rs2439831 0.850 rs12441861 chr15:44060883 C/T cg10011062 chr15:43941034 CATSPER2 -0.57 -8.57 -0.32 8.04e-17 Lung cancer in ever smokers; BRCA cis rs875971 1.000 rs6979382 chr7:65886375 C/T cg18876405 chr7:65276391 NA 0.56 13.15 0.46 3.81e-35 Aortic root size; BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg04944784 chr2:26401820 FAM59B -0.68 -11.33 -0.41 3.18e-27 Gut microbiome composition (summer); BRCA trans rs1200821 0.535 rs1208789 chr10:37722472 A/G cg25427524 chr10:38739819 LOC399744 -0.41 -8.81 -0.33 1.18e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs7586879 0.828 rs11675013 chr2:25107208 G/A cg04586622 chr2:25135609 ADCY3 0.39 9.5 0.35 4.06e-20 Body mass index; BRCA cis rs8031584 0.918 rs61997138 chr15:31270776 C/T cg14829155 chr15:31115871 NA -0.43 -9.74 -0.36 5.24e-21 Huntington's disease progression; BRCA cis rs6987853 0.966 rs2084709 chr8:42423190 A/G cg09913449 chr8:42400586 C8orf40 0.37 7.97 0.3 7.52e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs832540 0.519 rs10039338 chr5:56260363 C/T cg24531977 chr5:56204891 C5orf35 0.42 8.6 0.32 6.32e-17 Coronary artery disease; BRCA cis rs9790314 1.000 rs7647327 chr3:161016421 T/C cg03342759 chr3:160939853 NMD3 -0.64 -13.69 -0.48 1.3e-37 Morning vs. evening chronotype; BRCA cis rs7737355 0.773 rs32103 chr5:131030961 T/C cg06307176 chr5:131281290 NA 0.53 10.58 0.39 3.15e-24 Life satisfaction; BRCA cis rs7474896 0.522 rs117157955 chr10:37984164 G/T cg25427524 chr10:38739819 LOC399744 -0.53 -9.35 -0.35 1.51e-19 Obesity (extreme); BRCA cis rs600806 0.888 rs12046539 chr1:109875415 C/T cg20591472 chr1:110008990 SYPL2 0.32 7.94 0.3 9.19e-15 Intelligence (multi-trait analysis); BRCA cis rs911555 0.692 rs7140647 chr14:103893465 A/G cg24130564 chr14:104152367 KLC1 0.37 8.28 0.31 7.04e-16 Intelligence (multi-trait analysis); BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg19346786 chr7:2764209 NA -0.33 -9.89 -0.36 1.53e-21 Height; BRCA cis rs7520050 0.807 rs6429576 chr1:46216575 T/C cg24296786 chr1:45957014 TESK2 -0.46 -10.54 -0.38 4.68e-24 Red blood cell count;Reticulocyte count; BRCA cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg08847533 chr14:75593920 NEK9 -0.83 -20.8 -0.64 9.42e-74 Height; BRCA cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs6594499 0.564 rs12518884 chr5:110452223 A/G cg04022379 chr5:110408740 TSLP 0.4 9.17 0.34 6.44e-19 Allergic disease (asthma, hay fever or eczema); BRCA cis rs17253792 0.822 rs76267907 chr14:56066969 C/A cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs4664304 0.620 rs11675085 chr2:160713352 C/G cg02280532 chr2:160761244 LY75 0.35 7.85 0.3 1.81e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2859741 0.528 rs3753776 chr1:37480144 C/T cg09363841 chr1:37513479 NA -0.51 -10.92 -0.4 1.48e-25 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs2243480 0.901 rs2949697 chr7:65464236 A/G cg18252515 chr7:66147081 NA -0.85 -12.24 -0.44 4.45e-31 Diabetic kidney disease; BRCA trans rs2727020 0.521 rs2088526 chr11:49531968 G/A cg15704280 chr7:45808275 SEPT13 0.7 14.28 0.49 2.29e-40 Coronary artery disease; BRCA cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg12365402 chr11:9010492 NRIP3 -0.41 -9.62 -0.36 1.44e-20 Hemoglobin concentration; BRCA cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg03354898 chr7:1950403 MAD1L1 -0.4 -8.99 -0.33 2.85e-18 Schizophrenia; BRCA cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg18196295 chr10:418757 DIP2C 0.49 11.86 0.42 1.87e-29 Psychosis in Alzheimer's disease; BRCA cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg21573476 chr21:45109991 RRP1B -0.35 -9.31 -0.35 2e-19 Mean corpuscular volume; BRCA cis rs6700896 0.931 rs1805096 chr1:66102257 C/T cg04111102 chr1:66153794 NA 0.34 8.35 0.31 4.08e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs681343 0.746 rs633372 chr19:49209226 G/A cg07051648 chr19:49177693 NTN5;SEC1 -0.42 -8.02 -0.3 5.01e-15 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs28374715 0.609 rs8043237 chr15:41514298 G/A cg18705301 chr15:41695430 NDUFAF1 -0.83 -17.14 -0.56 1.73e-54 Ulcerative colitis; BRCA cis rs6809651 0.524 rs56940353 chr3:185798296 T/C cg00760338 chr3:185826511 ETV5 -0.49 -9.66 -0.36 1.11e-20 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs1448094 0.512 rs7134732 chr12:86241908 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.23 -0.34 3.96e-19 Major depressive disorder; BRCA cis rs1005224 0.853 rs61980778 chr14:76151532 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 0.35 8.26 0.31 8.29e-16 Large artery stroke; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg02353165 chr6:42928485 GNMT -0.6 -14.32 -0.49 1.45e-40 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9467773 0.869 rs742090 chr6:26415637 A/C cg09904177 chr6:26538194 HMGN4 -0.46 -13.26 -0.46 1.2e-35 Intelligence (multi-trait analysis); BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -11.92 -0.43 9.82e-30 Tonsillectomy; BRCA cis rs2635047 0.967 rs9960264 chr18:44606996 T/C cg19077165 chr18:44547161 KATNAL2 -0.44 -8.99 -0.33 2.86e-18 Educational attainment; BRCA cis rs6570726 0.846 rs409553 chr6:145886963 C/T cg23711669 chr6:146136114 FBXO30 0.72 17.35 0.57 1.59e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg10523679 chr1:76189770 ACADM 0.77 15.95 0.53 1.95e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7772486 0.790 rs9485024 chr6:146142487 A/G cg13319975 chr6:146136371 FBXO30 0.34 8.03 0.3 4.59e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.3 -0.44 2.28e-31 Developmental language disorder (linguistic errors); BRCA cis rs10782582 0.545 rs111927462 chr1:76195422 A/G cg03433033 chr1:76189801 ACADM -0.47 -8.96 -0.33 3.6e-18 Daytime sleep phenotypes; BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg22920501 chr2:26401640 FAM59B -0.67 -11.53 -0.42 4.47e-28 Gut microbiome composition (summer); BRCA cis rs9649465 0.967 rs2299986 chr7:123369539 T/C cg04330084 chr7:123175371 IQUB -0.31 -8.44 -0.32 2.13e-16 Migraine; BRCA cis rs1401999 1.000 rs1402003 chr3:183642879 C/T cg20387954 chr3:183756860 HTR3D 0.43 9.85 0.36 2.07e-21 Anterior chamber depth; BRCA cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg18402987 chr7:1209562 NA 0.52 9.0 0.34 2.55e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10170846 0.924 rs3768973 chr2:223436402 C/T cg25565276 chr2:223520875 FARSB 0.5 13.21 0.46 2.02e-35 Schizophrenia (inflammation and infection response interaction); BRCA cis rs7493 0.950 rs56265549 chr7:95047155 G/A cg19678392 chr7:94953810 PON1 -0.43 -9.01 -0.34 2.41e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10751667 0.666 rs10902249 chr11:958566 C/T cg01483505 chr11:975446 AP2A2 -0.33 -9.0 -0.34 2.57e-18 Alzheimer's disease (late onset); BRCA cis rs7524258 0.868 rs8179413 chr1:7267729 T/G cg07173049 chr1:7289937 CAMTA1 0.53 12.93 0.46 3.98e-34 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs1707322 0.682 rs12037459 chr1:46094959 T/G cg03146154 chr1:46216737 IPP 0.51 11.28 0.41 4.89e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6089829 0.962 rs6011544 chr20:61658782 T/C cg08045932 chr20:61659980 NA 0.49 11.08 0.4 3.09e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs2276314 1.000 rs16967317 chr18:33573400 A/G cg05985134 chr18:33552581 C18orf21 0.68 12.91 0.45 4.77e-34 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs9291683 0.632 rs13137074 chr4:10042842 C/T cg26043149 chr18:55253948 FECH 0.43 9.22 0.34 4.29e-19 Bone mineral density; BRCA cis rs2882667 0.898 rs2043272 chr5:138390631 A/C cg04439458 chr5:138467593 SIL1 -0.34 -9.41 -0.35 8.73e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3845702 0.668 rs3856415 chr2:180807367 G/A cg01881094 chr2:180872142 CWC22 -1.03 -18.02 -0.58 5.24e-59 Schizophrenia; BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.09 0.34 1.22e-18 Tonsillectomy; BRCA cis rs3925075 0.531 rs9673519 chr16:31347557 T/C cg02846316 chr16:31340340 ITGAM 0.42 8.56 0.32 8.58e-17 IgA nephropathy; BRCA cis rs6088590 1.000 rs1998028 chr20:33344595 A/T cg08999081 chr20:33150536 PIGU 0.36 9.29 0.35 2.35e-19 Coronary artery disease; BRCA cis rs7584330 0.737 rs10445707 chr2:238368751 A/G cg14458575 chr2:238380390 NA 0.48 10.84 0.39 3.1e-25 Prostate cancer; BRCA cis rs11148252 0.740 rs9526914 chr13:52976300 G/T cg00495681 chr13:53174319 NA 0.39 8.04 0.3 4.21e-15 Lewy body disease; BRCA cis rs1451375 0.572 rs11575463 chr7:50547173 A/G cg18232548 chr7:50535776 DDC -0.42 -8.91 -0.33 5.42e-18 Malaria; BRCA trans rs4650994 0.544 rs2811306 chr1:178599248 C/G cg05059571 chr16:84539110 KIAA1609 0.56 12.23 0.44 4.88e-31 HDL cholesterol levels;HDL cholesterol; BRCA cis rs9297145 0.724 rs62473013 chr7:98762418 G/T cg05967295 chr7:98741636 SMURF1 0.96 18.17 0.58 8.37e-60 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs72781680 0.950 rs72798404 chr2:24180125 C/T cg08917208 chr2:24149416 ATAD2B 1.1 15.51 0.52 2.65e-46 Lymphocyte counts; BRCA cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg10174797 chr19:8464628 RAB11B 0.36 9.17 0.34 6.2e-19 HDL cholesterol; BRCA cis rs6910061 1.000 rs34846077 chr6:11096561 G/A cg27233058 chr6:11094804 LOC221710 0.52 9.3 0.35 2.15e-19 Diabetic kidney disease; BRCA trans rs7395662 0.517 rs10454483 chr11:48754997 A/G cg15704280 chr7:45808275 SEPT13 -0.54 -10.84 -0.39 2.98e-25 HDL cholesterol; BRCA cis rs6598955 0.671 rs11247905 chr1:26627907 G/C cg04990556 chr1:26633338 UBXN11 0.55 9.24 0.34 3.56e-19 Obesity-related traits; BRCA cis rs6484504 0.625 rs4922859 chr11:31382517 A/G cg06552810 chr11:31128660 NA 0.38 8.6 0.32 6.04e-17 Red blood cell count; BRCA cis rs1568889 0.838 rs7121937 chr11:28359858 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 19.52 0.61 6.57e-67 Bipolar disorder; BRCA cis rs17270561 0.666 rs17320090 chr6:25720215 C/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.77 0.33 1.61e-17 Iron status biomarkers; BRCA cis rs6088813 1.000 rs6088825 chr20:33995972 C/T cg14752227 chr20:34000481 UQCC -0.42 -8.92 -0.33 4.73e-18 Height; BRCA cis rs7945705 0.774 rs6486060 chr11:9024630 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.56 12.29 0.44 2.7e-31 Hemoglobin concentration; BRCA cis rs67460515 0.563 rs4679672 chr3:160901020 G/A cg03342759 chr3:160939853 NMD3 -0.72 -15.25 -0.52 5.13e-45 Parkinson's disease; BRCA cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg17971929 chr21:40555470 PSMG1 0.8 18.71 0.59 1.3e-62 Cognitive function; BRCA cis rs2204008 0.837 rs2127955 chr12:37969194 A/G cg26384229 chr12:38710491 ALG10B 0.58 13.87 0.48 1.94e-38 Bladder cancer; BRCA cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg06115741 chr20:33292138 TP53INP2 0.52 11.55 0.42 3.81e-28 Coronary artery disease; BRCA cis rs7824557 0.843 rs2736375 chr8:11115749 C/T cg21775007 chr8:11205619 TDH -0.56 -11.32 -0.41 3.43e-27 Retinal vascular caliber; BRCA cis rs10752881 1.000 rs10797813 chr1:182989366 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.88 0.56 3.66e-53 Colorectal cancer; BRCA cis rs4908768 0.539 rs7537982 chr1:8644007 C/T cg20416874 chr1:8611966 RERE -0.29 -8.39 -0.31 3.21e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs9469578 1.000 rs9469582 chr6:33715939 A/G cg18708504 chr6:33715942 IP6K3 0.68 9.99 0.37 6.43e-22 Phosphorus levels; BRCA cis rs6912958 0.967 rs6914299 chr6:88149176 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -10.01 -0.37 5.31e-22 Monocyte percentage of white cells; BRCA cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg01877450 chr7:97915802 BRI3 -0.37 -8.33 -0.31 4.86e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs4148883 0.689 rs2602861 chr4:100030896 C/T cg13256891 chr4:100009986 ADH5 0.38 8.06 0.3 3.84e-15 Alcohol dependence; BRCA cis rs12142240 0.698 rs17357635 chr1:46808668 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs7560272 0.538 rs13006448 chr2:73924424 G/T cg20560298 chr2:73613845 ALMS1 0.35 9.03 0.34 1.99e-18 Schizophrenia; BRCA cis rs6733011 0.508 rs12712041 chr2:99522059 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.25 -0.34 3.45e-19 Bipolar disorder; BRCA cis rs1557765 0.527 rs11024272 chr11:17395760 T/C cg15432903 chr11:17409602 KCNJ11 0.4 8.55 0.32 9.28e-17 Body mass index;Social communication problems; BRCA cis rs7481584 0.624 rs412842 chr11:3047448 A/G cg08508325 chr11:3079039 CARS 0.28 8.49 0.32 1.5e-16 Calcium levels; BRCA cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg20503657 chr10:835505 NA 1.04 18.21 0.58 5.16e-60 Eosinophil percentage of granulocytes; BRCA trans rs7824557 0.767 rs1897950 chr8:11169551 C/A cg15556689 chr8:8085844 FLJ10661 0.37 8.73 0.33 2.22e-17 Retinal vascular caliber; BRCA cis rs1351164 0.591 rs9752576 chr2:218269445 G/A cg15335768 chr2:218268053 DIRC3 -0.38 -9.17 -0.34 6.66e-19 Height; BRCA cis rs9649213 0.593 rs13246868 chr7:97986453 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.12e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg26031613 chr14:104095156 KLC1 0.97 25.72 0.71 1.06e-100 Body mass index; BRCA cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg01579765 chr21:45077557 HSF2BP -0.45 -12.77 -0.45 2.01e-33 Mean corpuscular volume; BRCA cis rs17095355 1.000 rs12267704 chr10:111722008 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.82 -0.36 2.69e-21 Biliary atresia; BRCA cis rs10267417 0.603 rs28770193 chr7:19860804 A/T cg07541023 chr7:19748670 TWISTNB 0.47 8.73 0.33 2.23e-17 Night sleep phenotypes; BRCA cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg05535760 chr7:792225 HEATR2 0.72 13.3 0.47 8.12e-36 Cerebrospinal P-tau181p levels; BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.7 0.42 9.02e-29 Tonsillectomy; BRCA cis rs6963495 0.651 rs3892298 chr7:105152187 A/G cg13798780 chr7:105162888 PUS7 0.45 7.9 0.3 1.21e-14 Bipolar disorder (body mass index interaction); BRCA cis rs6433857 0.657 rs2368177 chr2:181501242 T/C cg23363182 chr2:181467187 NA -0.45 -9.73 -0.36 6.11e-21 Body mass index; BRCA cis rs3741404 0.609 rs635139 chr11:63872210 A/G cg18225595 chr11:63971243 STIP1 0.41 10.06 0.37 3.44e-22 Platelet count; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.56 10.07 0.37 3.2e-22 Gut microbiome composition (summer); BRCA trans rs208520 0.545 rs6899712 chr6:66749670 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.98 27.77 0.74 5.91e-112 Exhaled nitric oxide output; BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg27094323 chr7:1216898 NA -0.36 -8.19 -0.31 1.45e-15 Longevity;Endometriosis; BRCA cis rs6547741 0.904 rs2384628 chr2:27774702 T/G cg27432699 chr2:27873401 GPN1 0.46 9.46 0.35 5.92e-20 Oral cavity cancer; BRCA cis rs1967309 0.604 rs8061182 chr16:4070333 A/G cg00061520 chr16:4070371 ADCY9 0.37 8.0 0.3 5.69e-15 Response to Dalcetrapib treatment in acute coronary syndrome; BRCA cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs6459788 0.720 rs11768765 chr7:157253133 C/T cg06271696 chr7:157225062 NA -0.39 -10.3 -0.38 4.15e-23 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA trans rs61931739 0.635 rs3937819 chr12:33942715 A/G cg26384229 chr12:38710491 ALG10B 0.4 8.97 0.33 3.18e-18 Morning vs. evening chronotype; BRCA cis rs2274273 0.774 rs17128440 chr14:55861912 C/T cg04306507 chr14:55594613 LGALS3 0.3 8.25 0.31 9.21e-16 Protein biomarker; BRCA cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg24812749 chr6:127587940 RNF146 0.87 19.88 0.62 7.86e-69 Breast cancer; BRCA cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg27165867 chr14:105738592 BRF1 -0.36 -8.37 -0.31 3.53e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs7246657 0.551 rs11084873 chr19:37583910 A/G cg23950597 chr19:37808831 NA -0.64 -9.66 -0.36 1.04e-20 Coronary artery calcification; BRCA cis rs7943191 0.805 rs12226821 chr11:62369018 C/G cg13298116 chr11:62369859 EML3;MTA2 0.57 11.33 0.41 3.18e-27 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs11792861 0.816 rs72607157 chr9:111748001 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.81 0.3 2.3e-14 Menarche (age at onset); BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg14789911 chr21:47582049 C21orf56 -0.37 -7.98 -0.3 6.78e-15 Testicular germ cell tumor; BRCA cis rs3771570 1.000 rs56156035 chr2:242205955 T/A cg21155796 chr2:242212141 HDLBP 0.62 9.76 0.36 4.52e-21 Prostate cancer; BRCA cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.85e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs870825 0.616 rs1401358 chr4:185640057 C/T cg04058563 chr4:185651563 MLF1IP 0.74 16.93 0.56 2.21e-53 Blood protein levels; BRCA cis rs6546550 0.713 rs6718517 chr2:70018462 T/C cg02498382 chr2:70120550 SNRNP27 -0.4 -8.24 -0.31 9.62e-16 Prevalent atrial fibrillation; BRCA cis rs2836974 0.831 rs34592564 chr21:40516288 G/C cg11890956 chr21:40555474 PSMG1 0.94 21.62 0.65 3.15e-78 Cognitive function; BRCA cis rs8180040 0.654 rs4682831 chr3:47027138 A/G cg27129171 chr3:47204927 SETD2 -0.59 -13.62 -0.47 2.83e-37 Colorectal cancer; BRCA cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg18876405 chr7:65276391 NA -0.51 -11.75 -0.42 5.48e-29 Aortic root size; BRCA cis rs6088580 0.524 rs6088575 chr20:33273403 C/T cg24642439 chr20:33292090 TP53INP2 0.46 8.8 0.33 1.27e-17 Glomerular filtration rate (creatinine); BRCA cis rs1865760 0.713 rs6928951 chr6:25995554 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 11.12 0.4 2.15e-26 Height; BRCA cis rs546131 0.963 rs539044 chr11:34841542 G/T cg11058730 chr11:34937778 PDHX;APIP 0.45 8.64 0.32 4.51e-17 Lung disease severity in cystic fibrosis; BRCA cis rs9814567 1.000 rs10935120 chr3:134233092 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 9.08 0.34 1.35e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg03808351 chr9:123631620 PHF19 0.43 7.85 0.3 1.72e-14 Rheumatoid arthritis; BRCA cis rs7666738 0.830 rs28852677 chr4:99039509 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.02e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2742234 0.518 rs1254967 chr10:43690391 G/A cg15436174 chr10:43711423 RASGEF1A 0.57 11.47 0.41 7.89e-28 Hirschsprung disease; BRCA cis rs2153535 0.560 rs2210798 chr6:8481522 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.68e-18 Motion sickness; BRCA cis rs1568889 1.000 rs7937117 chr11:28370038 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.69 0.5 2.53e-42 Bipolar disorder; BRCA cis rs35740288 0.685 rs12899481 chr15:86308970 C/T cg20737812 chr15:86336631 KLHL25 -0.33 -8.05 -0.3 4.19e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA trans rs11098499 0.575 rs907204 chr4:120238654 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.3 0.38 4.19e-23 Corneal astigmatism; BRCA cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg06212747 chr3:49208901 KLHDC8B -0.45 -8.13 -0.31 2.22e-15 Menarche (age at onset); BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg02579736 chr3:10068473 FANCD2;CIDECP -0.85 -17.16 -0.56 1.5e-54 Alzheimer's disease; BRCA cis rs7945705 0.747 rs10840158 chr11:9020897 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -13.43 -0.47 2.14e-36 Hemoglobin concentration; BRCA cis rs6912958 0.500 rs2025486 chr6:87796886 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.59 -0.32 6.46e-17 Monocyte percentage of white cells; BRCA cis rs1552244 0.882 rs66559400 chr3:10012551 G/A cg00166722 chr3:10149974 C3orf24 0.55 11.13 0.4 1.93e-26 Alzheimer's disease; BRCA trans rs6598955 0.671 rs11247880 chr1:26568926 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.65 -14.22 -0.49 4.75e-40 Obesity-related traits; BRCA cis rs2032447 0.901 rs2213284 chr6:26031868 G/A cg03517284 chr6:25882590 NA -0.49 -10.19 -0.37 1.1e-22 Intelligence (multi-trait analysis); BRCA cis rs929354 0.772 rs3802123 chr7:156970641 G/A cg17757837 chr7:157058334 UBE3C 0.56 12.55 0.44 1.9e-32 Body mass index; BRCA cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg20573242 chr4:122745356 CCNA2 0.48 10.84 0.39 2.96e-25 Type 2 diabetes; BRCA cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg11833968 chr6:79620685 NA -0.44 -9.95 -0.37 8.48e-22 Intelligence (multi-trait analysis); BRCA cis rs2522056 1.000 rs2106854 chr5:131769174 C/T cg24060327 chr5:131705240 SLC22A5 0.44 7.81 0.3 2.33e-14 Lymphocyte counts;Fibrinogen; BRCA cis rs490234 0.812 rs2900229 chr9:128466312 A/G cg14078157 chr9:128172775 NA -0.36 -8.2 -0.31 1.29e-15 Mean arterial pressure; BRCA cis rs1005277 0.602 rs2504142 chr10:38383793 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.77e-26 Extrinsic epigenetic age acceleration; BRCA cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.96 26.35 0.72 3.76e-104 Birth weight; BRCA cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.65 0.39 1.77e-24 Bipolar disorder; BRCA cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg18446336 chr7:2847575 GNA12 -0.36 -8.35 -0.31 4.19e-16 Height; BRCA cis rs7590720 1.000 rs1991533 chr2:216908910 T/C cg12620499 chr2:216877984 MREG 0.79 21.44 0.65 3.09e-77 Alcohol dependence; BRCA trans rs2262909 0.962 rs11669110 chr19:22296485 A/G cg17074339 chr11:11642133 GALNTL4 0.44 8.62 0.32 5.06e-17 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs2880765 0.805 rs11858817 chr15:86031260 C/T cg10818794 chr15:86012489 AKAP13 -0.31 -8.61 -0.32 5.47e-17 Coronary artery disease; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26314531 chr2:26401878 FAM59B -0.62 -10.82 -0.39 3.45e-25 Gut microbiome composition (summer); BRCA cis rs9443645 0.901 rs12193319 chr6:79583437 C/A cg18132916 chr6:79620363 NA -0.47 -10.74 -0.39 7.41e-25 Intelligence (multi-trait analysis); BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg12444411 chr7:2802554 GNA12 -0.35 -8.74 -0.33 2.07e-17 Height; BRCA cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg22974920 chr21:40686053 BRWD1 -0.4 -8.91 -0.33 5.4e-18 Cognitive function; BRCA cis rs4481887 0.927 rs4405158 chr1:248490647 A/C cg00666640 chr1:248458726 OR2T12 0.32 8.94 0.33 4.09e-18 Common traits (Other); BRCA cis rs35740288 0.787 rs11637768 chr15:86223410 C/T cg20737812 chr15:86336631 KLHL25 -0.32 -7.87 -0.3 1.58e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg13010199 chr12:38710504 ALG10B -0.44 -10.19 -0.37 1.09e-22 Heart rate; BRCA cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg27535305 chr1:53392650 SCP2 0.4 9.84 0.36 2.22e-21 Monocyte count; BRCA cis rs7903847 0.667 rs11189181 chr10:99144154 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.34 -0.31 4.51e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs17270561 0.636 rs3922681 chr6:25698481 C/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.56 0.32 8.24e-17 Iron status biomarkers; BRCA trans rs61931739 0.534 rs11053049 chr12:34164537 T/C cg13010199 chr12:38710504 ALG10B 0.5 9.7 0.36 7.46e-21 Morning vs. evening chronotype; BRCA cis rs11764590 0.671 rs12669370 chr7:2081914 G/A cg23422044 chr7:1970798 MAD1L1 -0.43 -8.79 -0.33 1.41e-17 Neuroticism; BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg08470875 chr2:26401718 FAM59B -0.63 -9.47 -0.35 5.17e-20 Gut microbiome composition (summer); BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg25703541 chr22:24373054 LOC391322 -0.69 -16.0 -0.53 1.09e-48 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6546550 0.935 rs11673826 chr2:70041033 G/A cg02498382 chr2:70120550 SNRNP27 -0.41 -8.79 -0.33 1.4e-17 Prevalent atrial fibrillation; BRCA trans rs6952808 0.636 rs6964522 chr7:1953523 C/T cg04565464 chr8:145669602 NFKBIL2 0.36 8.81 0.33 1.16e-17 Bipolar disorder and schizophrenia; BRCA trans rs11577318 0.812 rs3795683 chr1:26632831 C/A cg07461501 chr17:79650226 HGS;ARL16 0.4 10.09 0.37 2.5e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg00599163 chr2:162100495 NA 0.27 8.83 0.33 9.71e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA trans rs853679 0.607 rs13216117 chr6:27938484 A/G cg01620082 chr3:125678407 NA -0.98 -11.11 -0.4 2.38e-26 Depression; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26314531 chr2:26401878 FAM59B -0.92 -14.35 -0.49 1.07e-40 Gut microbiome composition (summer); BRCA cis rs7301826 0.651 rs10773824 chr12:131298851 G/A cg11011512 chr12:131303247 STX2 0.49 12.98 0.46 2.3e-34 Plasma plasminogen activator levels; BRCA cis rs9612 0.718 rs346522 chr19:44262545 C/T cg08581076 chr19:44259116 C19orf61 -0.45 -8.2 -0.31 1.33e-15 Exhaled nitric oxide output; BRCA cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg21475434 chr5:93447410 FAM172A 0.69 8.65 0.32 4.07e-17 Diabetic retinopathy; BRCA trans rs6582618 1 rs6582618 chr12:38726137 A/G cg23762105 chr12:34175262 ALG10 -0.37 -9.41 -0.35 9.01e-20 Morning vs. evening chronotype; BRCA cis rs7640424 0.649 rs17233248 chr3:107899513 T/C cg09227934 chr3:107805635 CD47 -0.38 -7.9 -0.3 1.27e-14 Body mass index; BRCA cis rs17270561 0.636 rs4145218 chr6:25746083 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.81e-17 Iron status biomarkers; BRCA cis rs12949688 0.934 rs12449409 chr17:55822467 G/A cg12582317 chr17:55822272 NA 0.32 7.93 0.3 9.97e-15 Schizophrenia; BRCA cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg20701182 chr2:24300061 SF3B14 0.71 13.18 0.46 2.85e-35 Lymphocyte counts; BRCA cis rs7020830 0.516 rs36047049 chr9:37375472 G/T cg14294708 chr9:37120828 ZCCHC7 0.89 16.76 0.55 1.5e-52 Schizophrenia; BRCA cis rs9814567 0.963 rs9844537 chr3:134238341 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.49 -0.61 9.03e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs765787 0.530 rs3759893 chr15:45542950 G/T cg24006582 chr15:45444508 DUOX1 -0.56 -11.58 -0.42 2.68e-28 Uric acid levels; BRCA cis rs67478160 0.595 rs8022783 chr14:104245573 T/C cg08213375 chr14:104286397 PPP1R13B 0.64 18.34 0.59 1.12e-60 Schizophrenia; BRCA cis rs3008870 1.000 rs3008874 chr1:67431365 A/T cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.78 0.67 1.56e-84 Lymphocyte percentage of white cells; BRCA cis rs1577917 0.958 rs6921315 chr6:86471668 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -8.05 -0.3 4.07e-15 Response to antipsychotic treatment; BRCA cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg06550200 chr5:1325588 CLPTM1L -0.62 -13.08 -0.46 7.84e-35 Lung cancer; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg12564285 chr5:131593104 PDLIM4 -0.37 -9.73 -0.36 5.66e-21 Breast cancer; BRCA cis rs950173 1.000 rs950173 chr2:172570419 G/A cg13550731 chr2:172543902 DYNC1I2 -0.72 -10.24 -0.38 6.94e-23 Hippocampal volume; BRCA cis rs6570726 1.000 rs386678 chr6:145869010 A/G cg23711669 chr6:146136114 FBXO30 0.63 14.05 0.49 2.88e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg00106254 chr7:1943704 MAD1L1 -0.45 -12.24 -0.44 4.18e-31 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.595 rs77615399 chr8:58117394 C/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg05025164 chr4:1340916 KIAA1530 0.39 8.84 0.33 9.58e-18 Longevity; BRCA cis rs652260 1.000 rs590394 chr19:7902505 C/T cg26014689 chr19:7917955 EVI5L -0.51 -11.69 -0.42 9.84e-29 Menarche (age at onset); BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg01577475 chr2:114033581 PAX8;LOC440839 -0.29 -8.08 -0.3 3.31e-15 Lymphocyte counts; BRCA cis rs1005277 0.579 rs1780130 chr10:38485378 T/A cg00409905 chr10:38381863 ZNF37A -0.49 -10.11 -0.37 2.19e-22 Extrinsic epigenetic age acceleration; BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 0.86 14.36 0.49 9.42e-41 Platelet count; BRCA cis rs7246657 0.722 rs10410588 chr19:38042410 C/G cg18154014 chr19:37997991 ZNF793 0.48 9.08 0.34 1.32e-18 Coronary artery calcification; BRCA cis rs7385804 0.633 rs221795 chr7:100283261 C/T cg20848291 chr7:100343083 ZAN 0.38 8.31 0.31 5.79e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7587476 0.501 rs11888027 chr2:215639612 A/C cg04004882 chr2:215674386 BARD1 -0.42 -8.89 -0.33 6.38e-18 Neuroblastoma; BRCA cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg24130564 chr14:104152367 KLC1 0.36 8.0 0.3 5.9e-15 Intelligence (multi-trait analysis); BRCA cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg19539972 chr4:7069911 GRPEL1 0.72 16.98 0.56 1.19e-53 Monocyte percentage of white cells; BRCA cis rs2033711 0.840 rs4801590 chr19:58961813 G/C cg13877915 chr19:58951672 ZNF132 0.46 10.84 0.39 3.05e-25 Uric acid clearance; BRCA cis rs6088813 0.961 rs6060373 chr20:33914208 C/T cg14752227 chr20:34000481 UQCC -0.39 -8.43 -0.32 2.34e-16 Height; BRCA cis rs1635 0.655 rs16893975 chr6:28302278 C/T cg15743358 chr6:28303923 ZNF323 0.69 8.09 0.3 3.03e-15 Schizophrenia; BRCA cis rs7789940 0.904 rs12531348 chr7:75937191 G/C cg10167463 chr7:75959203 YWHAG -0.43 -8.42 -0.32 2.55e-16 Multiple sclerosis; BRCA cis rs6684514 1.000 rs10908496 chr1:156264000 G/A cg16558208 chr1:156270281 VHLL 0.36 8.43 0.32 2.35e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs6088580 0.543 rs13042351 chr20:33238573 G/A cg08999081 chr20:33150536 PIGU -0.32 -8.41 -0.32 2.77e-16 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.562 rs2014516 chr8:58128288 C/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.517 rs10844727 chr12:34017435 C/T cg06521331 chr12:34319734 NA -0.59 -11.48 -0.41 7.48e-28 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs3925075 1.000 rs12923297 chr16:31360944 T/C cg02846316 chr16:31340340 ITGAM 0.53 12.97 0.46 2.69e-34 IgA nephropathy; BRCA cis rs4481887 0.962 rs10788769 chr1:248457426 C/T cg00666640 chr1:248458726 OR2T12 0.33 8.66 0.32 3.96e-17 Common traits (Other); BRCA cis rs1153858 0.887 rs7171163 chr15:45636395 A/C cg21132104 chr15:45694354 SPATA5L1 0.71 15.77 0.53 1.45e-47 Homoarginine levels; BRCA cis rs867371 1.000 rs6495642 chr15:82457497 G/C cg00614314 chr15:82944287 LOC80154 0.44 9.14 0.34 8.41e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs11252926 0.565 rs60553947 chr10:474284 T/C cg18196295 chr10:418757 DIP2C -0.49 -11.06 -0.4 3.81e-26 Psychosis in Alzheimer's disease; BRCA cis rs35995292 0.534 rs28460817 chr7:38921917 T/C cg19327137 chr7:38886074 VPS41 0.38 12.76 0.45 2.2e-33 Subjective well-being (multi-trait analysis); BRCA cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg12193833 chr17:30244370 NA -0.58 -8.9 -0.33 5.51e-18 Hip circumference adjusted for BMI; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg27170947 chr2:26402098 FAM59B 0.97 16.87 0.56 4.19e-53 Gut microbiome composition (summer); BRCA cis rs6088590 0.561 rs3891369 chr20:33161127 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.47 0.32 1.68e-16 Coronary artery disease; BRCA cis rs9463078 0.625 rs12190136 chr6:44767072 A/G cg25276700 chr6:44698697 NA -0.35 -8.26 -0.31 8.43e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.7 -12.12 -0.43 1.4e-30 Platelet count; BRCA cis rs4664304 0.710 rs9636280 chr2:160717852 C/T cg01092293 chr2:160761427 LY75 -0.4 -9.64 -0.36 1.27e-20 Crohn's disease;Inflammatory bowel disease; BRCA cis rs3857067 0.806 rs6817795 chr4:95127716 T/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.57 -0.35 2.22e-20 QT interval; BRCA trans rs8002861 0.935 rs7318147 chr13:44445153 C/G cg17145862 chr1:211918768 LPGAT1 -0.58 -12.7 -0.45 4.13e-33 Leprosy; BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs2880765 0.835 rs4526974 chr15:86024284 C/T cg10818794 chr15:86012489 AKAP13 -0.31 -8.59 -0.32 6.71e-17 Coronary artery disease; BRCA cis rs1568889 0.838 rs10835304 chr11:28296529 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 19.47 0.61 1.2e-66 Bipolar disorder; BRCA cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg19482086 chr6:160211437 TCP1;MRPL18 -0.75 -22.0 -0.66 2.64e-80 Age-related macular degeneration (geographic atrophy); BRCA cis rs6121246 0.909 rs2376992 chr20:30263418 T/C cg13852791 chr20:30311386 BCL2L1 0.85 16.41 0.54 9.49e-51 Mean corpuscular hemoglobin; BRCA cis rs11098499 0.644 rs17517414 chr4:120262101 G/C cg09307838 chr4:120376055 NA 0.59 12.95 0.46 3.11e-34 Corneal astigmatism; BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.1 0.34 1.12e-18 Tonsillectomy; BRCA cis rs6598955 0.671 rs17257176 chr1:26578233 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg22875332 chr1:76189707 ACADM -0.53 -10.08 -0.37 2.94e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17095355 1.000 rs12570145 chr10:111712913 A/G cg00817464 chr10:111662876 XPNPEP1 -0.44 -9.57 -0.35 2.2e-20 Biliary atresia; BRCA trans rs2262909 1.000 rs2017962 chr19:22208751 T/C cg17074339 chr11:11642133 GALNTL4 -0.41 -7.86 -0.3 1.64e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs4308124 0.708 rs10178095 chr2:111972516 C/T cg04571233 chr2:111982156 NA -0.45 -9.58 -0.35 2.12e-20 Vitiligo; BRCA cis rs2153535 0.542 rs9378553 chr6:8472632 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs694739 1.000 rs499425 chr11:64105929 A/G cg23796481 chr11:64053134 BAD;GPR137 -0.51 -10.59 -0.39 2.84e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs10911363 0.659 rs7518244 chr1:183434807 C/T cg09173681 chr1:183549694 NCF2 -0.53 -11.12 -0.4 2.21e-26 Systemic lupus erythematosus; BRCA cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg11764359 chr7:65958608 NA -0.62 -13.27 -0.46 1.09e-35 Aortic root size; BRCA cis rs7267979 0.966 rs2500417 chr20:25383287 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.43 -0.32 2.31e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg16606324 chr3:10149918 C3orf24 0.53 10.53 0.38 5.16e-24 Alzheimer's disease; BRCA cis rs3741404 0.574 rs616563 chr11:63877501 G/C cg18225595 chr11:63971243 STIP1 0.45 10.88 0.4 2.06e-25 Platelet count; BRCA cis rs11098499 0.542 rs10440343 chr4:120309787 G/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg03517284 chr6:25882590 NA -0.37 -8.2 -0.31 1.34e-15 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.632 rs62541899 chr9:5143291 C/T cg02405213 chr9:5042618 JAK2 -0.49 -8.93 -0.33 4.54e-18 Pediatric autoimmune diseases; BRCA cis rs17034641 0.744 rs2053797 chr2:46370892 C/T cg12428440 chr2:46370979 PRKCE 0.47 8.51 0.32 1.2e-16 Hemoglobin;Hematocrit; BRCA cis rs12701220 0.894 rs12701406 chr7:1050283 G/A cg06145435 chr7:1022769 CYP2W1 0.49 9.02 0.34 2.23e-18 Bronchopulmonary dysplasia; BRCA cis rs6089584 0.816 rs4925336 chr20:60627180 A/G cg13770153 chr20:60521292 NA -0.44 -9.81 -0.36 3.02e-21 Body mass index; BRCA cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg26116260 chr4:7069785 GRPEL1 0.93 26.3 0.72 6.74e-104 Monocyte percentage of white cells; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg05793240 chr7:2802953 GNA12 -0.29 -7.87 -0.3 1.49e-14 Height; BRCA cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg14019146 chr3:50243930 SLC38A3 -0.4 -9.81 -0.36 2.96e-21 Intelligence (multi-trait analysis); BRCA cis rs4332037 0.510 rs58673065 chr7:1885600 A/G cg12591125 chr7:1885375 MAD1L1 0.43 8.74 0.33 2.12e-17 Bipolar disorder; BRCA cis rs524281 0.773 rs11227413 chr11:65883696 G/A cg16950941 chr11:66035639 RAB1B -0.39 -8.23 -0.31 1.02e-15 Electroencephalogram traits; BRCA cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs4363385 0.818 rs10788856 chr1:153011517 G/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA trans rs9467711 0.659 rs13195509 chr6:26463660 C/T cg01620082 chr3:125678407 NA -0.71 -8.61 -0.32 5.56e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs9649465 1.000 rs10238422 chr7:123353708 G/C cg04330084 chr7:123175371 IQUB -0.31 -8.45 -0.32 1.95e-16 Migraine; BRCA cis rs2180341 0.920 rs7756880 chr6:127683999 A/T cg24812749 chr6:127587940 RNF146 0.87 20.07 0.62 7.99e-70 Breast cancer; BRCA cis rs7095944 0.644 rs4962694 chr10:126436717 G/T cg08799069 chr10:126477246 METTL10 -0.4 -9.49 -0.35 4.41e-20 Asthma; BRCA cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg09359103 chr1:154839909 KCNN3 -0.6 -15.79 -0.53 1.09e-47 Prostate cancer; BRCA cis rs9400271 0.632 rs9384705 chr6:109588244 T/C cg01475377 chr6:109611718 NA -0.43 -10.27 -0.38 5.14e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs17428076 0.556 rs12692976 chr2:172684403 G/T cg13550731 chr2:172543902 DYNC1I2 -0.51 -12.66 -0.45 6.2e-33 Myopia; BRCA cis rs7789940 0.904 rs73140040 chr7:75936240 C/T cg10167463 chr7:75959203 YWHAG -0.42 -8.3 -0.31 6.02e-16 Multiple sclerosis; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg10729496 chr3:10149963 C3orf24 -0.51 -9.57 -0.35 2.28e-20 Alzheimer's disease; BRCA cis rs698813 0.851 rs2592199 chr2:44710169 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 8.77 0.33 1.65e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 13.86 0.48 2.16e-38 Personality dimensions; BRCA cis rs2387326 0.717 rs77277629 chr10:129944462 C/T cg16087940 chr10:129947807 NA -0.51 -8.29 -0.31 6.83e-16 Select biomarker traits; BRCA cis rs6062302 0.548 rs4809310 chr20:62228745 G/A cg03425785 chr20:62221387 GMEB2 0.51 8.26 0.31 8.42e-16 Glioblastoma; BRCA cis rs45509595 0.659 rs390764 chr6:27782535 C/T cg26587870 chr6:27730563 NA -0.52 -8.02 -0.3 5.04e-15 Breast cancer; BRCA cis rs6460942 0.915 rs62447642 chr7:12489147 T/C cg20607287 chr7:12443886 VWDE -0.59 -8.31 -0.31 5.68e-16 Coronary artery disease; BRCA cis rs7512552 0.839 rs1260421 chr1:150357780 G/A cg15654264 chr1:150340011 RPRD2 0.44 9.44 0.35 6.94e-20 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.62 12.87 0.45 7.41e-34 Lymphocyte counts; BRCA cis rs13256369 1.000 rs13266699 chr8:8570313 A/T cg18904891 chr8:8559673 CLDN23 -0.62 -12.13 -0.43 1.3e-30 Obesity-related traits; BRCA cis rs7618501 0.633 rs4688757 chr3:50035323 T/C cg24110177 chr3:50126178 RBM5 -0.36 -9.79 -0.36 3.4e-21 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg12311346 chr5:56204834 C5orf35 -0.73 -13.46 -0.47 1.56e-36 Initial pursuit acceleration; BRCA cis rs6545883 0.929 rs1186711 chr2:61688505 T/C cg15711740 chr2:61764176 XPO1 -0.56 -13.36 -0.47 4.21e-36 Tuberculosis; BRCA cis rs2070433 0.539 rs2839314 chr21:47961067 A/G cg12379764 chr21:47803548 PCNT 0.57 12.08 0.43 2.19e-30 Lymphocyte counts; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg04013093 chr6:42928303 GNMT -0.29 -8.9 -0.33 5.85e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs769267 1.000 rs12985655 chr19:19442434 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.48 -9.83 -0.36 2.49e-21 Tonsillectomy; BRCA cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg18230493 chr5:56204884 C5orf35 0.58 12.41 0.44 8.1e-32 Initial pursuit acceleration; BRCA cis rs7927592 0.913 rs59056571 chr11:68272973 T/G cg20283391 chr11:68216788 NA -0.48 -9.36 -0.35 1.35e-19 Total body bone mineral density; BRCA cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg11822812 chr5:140052017 DND1 -0.3 -8.41 -0.32 2.7e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs4588572 0.644 rs1159930 chr5:77768943 C/T cg11547950 chr5:77652471 NA 0.44 8.56 0.32 8.24e-17 Triglycerides; BRCA cis rs6942756 0.774 rs891545 chr7:128866616 A/C cg02491457 chr7:128862824 NA 0.59 12.67 0.45 5.8e-33 White matter hyperintensity burden; BRCA cis rs881375 0.678 rs3761846 chr9:123689597 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.08 0.4 3.17e-26 Rheumatoid arthritis; BRCA cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg16179182 chr5:140090404 VTRNA1-1 0.41 9.51 0.35 3.8e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg24549020 chr5:56110836 MAP3K1 0.55 10.98 0.4 7.84e-26 Initial pursuit acceleration; BRCA cis rs17767294 0.708 rs72848786 chr6:27980017 G/A cg08851530 chr6:28072375 NA 1.13 10.5 0.38 6.89e-24 Parkinson's disease; BRCA cis rs2645694 0.626 rs2645708 chr4:77822682 G/A cg10057126 chr4:77819792 ANKRD56 0.65 15.2 0.52 8.87e-45 Emphysema distribution in smoking; BRCA cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg17509989 chr5:176798049 RGS14 0.64 12.86 0.45 8.13e-34 Hemoglobin concentration;Hematocrit; BRCA cis rs10045504 0.502 rs72746043 chr5:38757226 T/C cg15396434 chr5:38725168 NA -0.57 -10.71 -0.39 9.92e-25 Night sleep phenotypes; BRCA trans rs3942852 0.910 rs10742831 chr11:48119691 G/A cg15704280 chr7:45808275 SEPT13 -0.46 -8.12 -0.31 2.45e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs6433895 0.710 rs11692625 chr2:182015484 C/T cg00481216 chr2:181971175 NA 0.43 8.05 0.3 4.14e-15 Lymphocyte counts; BRCA cis rs12220238 1.000 rs10824084 chr10:75911415 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.5 8.09 0.3 3.05e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs13118159 0.801 rs7690727 chr4:1340811 C/A cg02475777 chr4:1388615 CRIPAK 0.41 9.3 0.35 2.17e-19 Longevity; BRCA trans rs2018683 0.523 rs4513881 chr7:29025410 C/T cg19402173 chr7:128379420 CALU 0.4 8.96 0.33 3.62e-18 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs7264396 0.563 rs2425090 chr20:34304783 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.05e-30 Total cholesterol levels; BRCA cis rs2901460 0.509 rs6721488 chr2:62071562 A/T cg02183531 chr2:62113199 CCT4 -0.46 -9.14 -0.34 7.99e-19 Mean corpuscular volume; BRCA cis rs4302748 0.862 rs11974973 chr7:36184850 A/T cg24442661 chr7:36192818 EEPD1 -0.45 -8.6 -0.32 6.24e-17 Platelet count; BRCA cis rs2580764 0.565 rs2044291 chr2:55247954 A/G cg09592903 chr2:55203963 RTN4 -0.4 -10.33 -0.38 3.03e-23 Mean platelet volume; BRCA cis rs2882667 0.628 rs13173618 chr5:138139780 T/G cg04439458 chr5:138467593 SIL1 -0.42 -9.32 -0.35 1.85e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs524281 0.861 rs11227410 chr11:65873396 G/C cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4.15e-15 Electroencephalogram traits; BRCA cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11890956 chr21:40555474 PSMG1 0.85 22.02 0.66 2.17e-80 Cognitive function; BRCA cis rs7917772 0.582 rs12782153 chr10:104368294 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.78 -0.48 5.21e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg11707556 chr5:10655725 ANKRD33B -0.47 -10.9 -0.4 1.67e-25 Height; BRCA cis rs887829 0.570 rs6736743 chr2:234595950 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.28 -0.31 7e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs9341808 0.754 rs6916405 chr6:81024188 C/T cg08355045 chr6:80787529 NA 0.36 9.26 0.34 3e-19 Sitting height ratio; BRCA cis rs12995491 1.000 rs12995491 chr2:88527414 C/T cg04511125 chr2:88470314 THNSL2 0.45 9.35 0.35 1.4e-19 Response to metformin (IC50); BRCA trans rs801193 0.901 rs4273746 chr7:66301111 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.24 -0.31 9.86e-16 Aortic root size; BRCA cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.55 7.86 0.3 1.65e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg16606324 chr3:10149918 C3orf24 0.56 10.97 0.4 9.02e-26 Alzheimer's disease; BRCA trans rs587242 0.955 rs12739556 chr1:96977901 C/T cg10631902 chr5:14652156 NA 0.44 10.72 0.39 8.96e-25 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs9462027 0.628 rs9462019 chr6:34748730 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.2e-15 Systemic lupus erythematosus; BRCA cis rs34891900 0.507 rs9605364 chr22:18127437 G/A cg19898043 chr22:18121309 BCL2L13 0.45 8.93 0.33 4.6e-18 Sum neutrophil eosinophil counts; BRCA cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg16405210 chr4:1374714 KIAA1530 -0.48 -11.07 -0.4 3.66e-26 Longevity; BRCA cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg20090143 chr19:45452003 APOC2 0.27 8.04 0.3 4.46e-15 Blood protein levels; BRCA cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.98e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs11758351 1.000 rs111596617 chr6:26191678 A/T cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs1595825 0.786 rs75415672 chr2:198535679 G/A cg19156104 chr2:198669113 PLCL1 -0.44 -8.36 -0.31 3.9e-16 Ulcerative colitis; BRCA cis rs8016982 0.657 rs8021125 chr14:81704787 C/T cg01989461 chr14:81687754 GTF2A1 -0.59 -14.06 -0.49 2.56e-39 Schizophrenia; BRCA cis rs875971 0.862 rs13536 chr7:66019190 G/A cg18876405 chr7:65276391 NA -0.5 -11.07 -0.4 3.5e-26 Aortic root size; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg00166722 chr3:10149974 C3orf24 0.65 12.84 0.45 9.71e-34 Alzheimer's disease; BRCA cis rs6964587 0.839 rs9656002 chr7:91475007 A/G cg17063962 chr7:91808500 NA -0.51 -11.61 -0.42 2.13e-28 Breast cancer; BRCA cis rs1941023 0.503 rs4939350 chr11:60136243 C/G cg08716584 chr11:60157161 MS4A7 -0.44 -10.25 -0.38 6.36e-23 Congenital heart disease (maternal effect); BRCA cis rs2033711 0.870 rs1465789 chr19:58946056 C/T cg13877915 chr19:58951672 ZNF132 0.45 10.35 0.38 2.6e-23 Uric acid clearance; BRCA cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg11843238 chr5:131593191 PDLIM4 0.35 7.83 0.3 2e-14 Breast cancer; BRCA cis rs1691799 0.899 rs1168310 chr12:66726355 A/G cg16791601 chr12:66731901 HELB 0.63 16.64 0.55 6.11e-52 White blood cell count (basophil); BRCA cis rs17539620 0.519 rs4077066 chr6:154838448 C/G cg20019720 chr6:154832845 CNKSR3 0.56 13.06 0.46 1.06e-34 Lipoprotein (a) levels; BRCA cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg08601574 chr20:25228251 PYGB -0.34 -8.19 -0.31 1.4e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg22153463 chr1:85462885 MCOLN2 -0.62 -11.15 -0.4 1.63e-26 Serum sulfate level; BRCA cis rs4689592 0.587 rs6825954 chr4:7074226 T/C cg26116260 chr4:7069785 GRPEL1 0.9 22.98 0.67 1.27e-85 Monocyte percentage of white cells; BRCA cis rs11098499 0.775 rs2002049 chr4:120257417 A/G cg09307838 chr4:120376055 NA 0.63 13.63 0.47 2.45e-37 Corneal astigmatism; BRCA cis rs10883723 0.738 rs715438 chr10:104258303 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.97 0.58 9.44e-59 Allergic disease (asthma, hay fever or eczema); BRCA cis rs9560113 1.000 rs9555805 chr13:112179765 C/T cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs12824058 0.831 rs12322456 chr12:130813594 A/G cg23887609 chr12:130822674 PIWIL1 0.42 9.14 0.34 8.42e-19 Menopause (age at onset); BRCA trans rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.48 -10.78 -0.39 5.19e-25 Brugada syndrome; BRCA trans rs3812049 0.826 rs6860245 chr5:127367998 G/C cg16011800 chr17:1958478 HIC1 0.5 8.16 0.31 1.74e-15 Lymphocyte counts;Red cell distribution width; BRCA cis rs8028182 0.636 rs8029112 chr15:75808972 T/C cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs950776 0.518 rs1979907 chr15:78842239 T/C cg22563815 chr15:78856949 CHRNA5 -0.36 -8.48 -0.32 1.52e-16 Sudden cardiac arrest; BRCA cis rs4474465 0.646 rs10751297 chr11:78278567 C/T cg27205649 chr11:78285834 NARS2 0.4 13.69 0.48 1.37e-37 Alzheimer's disease (survival time); BRCA cis rs9467773 0.933 rs35355150 chr6:26526039 G/A cg09904177 chr6:26538194 HMGN4 0.53 15.82 0.53 8.05e-48 Intelligence (multi-trait analysis); BRCA cis rs939658 0.805 rs36068099 chr15:79438598 G/C cg17916960 chr15:79447300 NA -0.43 -11.02 -0.4 5.66e-26 Refractive error; BRCA cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.55 11.24 0.41 7.36e-27 Multiple sclerosis; BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg22535103 chr8:58192502 C8orf71 -0.46 -8.09 -0.3 3.08e-15 Developmental language disorder (linguistic errors); BRCA cis rs78707713 0.560 rs12784882 chr10:71230334 C/G cg12610070 chr10:71211762 TSPAN15 -0.33 -10.03 -0.37 4.34e-22 Venous thromboembolism; BRCA cis rs6912958 0.781 rs9450739 chr6:88268271 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.49 -0.32 1.47e-16 Monocyte percentage of white cells; BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.54 -0.32 9.62e-17 Total body bone mineral density; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg24101359 chr6:42928495 GNMT 0.54 12.83 0.45 1.04e-33 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs11098499 0.908 rs2017057 chr4:120257711 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.41 0.32 2.59e-16 Corneal astigmatism; BRCA cis rs6088590 1.000 rs6120750 chr20:33465289 A/C cg06115741 chr20:33292138 TP53INP2 0.5 10.91 0.4 1.59e-25 Coronary artery disease; BRCA cis rs4481887 0.927 rs4409694 chr1:248485498 C/T cg00666640 chr1:248458726 OR2T12 0.3 8.38 0.31 3.3e-16 Common traits (Other); BRCA cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg24110177 chr3:50126178 RBM5 -0.53 -15.91 -0.53 2.93e-48 Intelligence (multi-trait analysis); BRCA cis rs12410462 0.901 rs16847844 chr1:227638110 A/G cg04117972 chr1:227635322 NA 0.44 8.07 0.3 3.62e-15 Major depressive disorder; BRCA cis rs2624839 0.704 rs2624838 chr3:50205642 C/G cg14019146 chr3:50243930 SLC38A3 -0.53 -13.03 -0.46 1.33e-34 Intelligence (multi-trait analysis); BRCA cis rs4808199 0.895 rs2163805 chr19:19575945 G/A cg03709012 chr19:19516395 GATAD2A 1.08 20.88 0.64 3.37e-74 Nonalcoholic fatty liver disease; BRCA cis rs10046574 0.831 rs77819442 chr7:135072552 C/T cg27474649 chr7:135195673 CNOT4 0.59 7.93 0.3 9.85e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs8180040 0.620 rs4683322 chr3:47093189 T/C cg16586182 chr3:47516702 SCAP -0.55 -12.44 -0.44 5.89e-32 Colorectal cancer; BRCA cis rs7772486 0.790 rs7753696 chr6:146279098 G/T cg23711669 chr6:146136114 FBXO30 -0.78 -17.76 -0.57 1.16e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs921968 0.541 rs620596 chr2:219462419 G/A cg10223061 chr2:219282414 VIL1 -0.27 -8.08 -0.3 3.13e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg11663144 chr21:46675770 NA -0.57 -13.58 -0.47 4.45e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11984145 1.000 rs73121381 chr7:38864327 A/G cg19327137 chr7:38886074 VPS41 0.5 9.14 0.34 8.08e-19 Cognitive performance; BRCA cis rs67460515 0.563 rs1585481 chr3:160901481 C/T cg03342759 chr3:160939853 NMD3 -0.72 -15.27 -0.52 4.04e-45 Parkinson's disease; BRCA cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg14844989 chr11:31128820 NA 0.45 9.63 0.36 1.33e-20 Red blood cell count; BRCA cis rs11105298 0.891 rs11105318 chr12:89926658 C/T cg00757033 chr12:89920650 WDR51B 0.48 9.31 0.35 1.97e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7599312 1.000 rs7599312 chr2:213413231 C/T cg20637307 chr2:213403960 ERBB4 0.49 10.43 0.38 1.23e-23 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7267979 1.000 rs6083804 chr20:25317060 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1538970 0.816 rs12029322 chr1:45970446 C/T cg05343316 chr1:45956843 TESK2 0.69 14.37 0.49 9.34e-41 Platelet count; BRCA cis rs3771570 0.901 rs3821285 chr2:242421314 A/G cg21155796 chr2:242212141 HDLBP -0.49 -8.63 -0.32 4.83e-17 Prostate cancer; BRCA cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg11663144 chr21:46675770 NA -0.5 -10.2 -0.37 9.97e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9329221 0.772 rs7824675 chr8:10243418 G/T cg27411982 chr8:10470053 RP1L1 -0.32 -8.13 -0.31 2.22e-15 Neuroticism; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg03188948 chr7:1209495 NA 0.62 12.87 0.45 7.41e-34 Longevity;Endometriosis; BRCA cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg19318889 chr4:1322082 MAEA 0.48 10.21 0.37 8.9e-23 Longevity; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg23131131 chr22:24373011 LOC391322 -0.48 -11.44 -0.41 1.06e-27 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2625529 0.529 rs1552133 chr15:72232897 T/A cg16672083 chr15:72433130 SENP8 0.67 15.81 0.53 9.1e-48 Red blood cell count; BRCA cis rs4689592 0.503 rs66885632 chr4:7053738 T/C cg26116260 chr4:7069785 GRPEL1 -0.85 -16.84 -0.55 6e-53 Monocyte percentage of white cells; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg10729496 chr3:10149963 C3orf24 0.48 9.07 0.34 1.41e-18 Alzheimer's disease; BRCA cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg21017887 chr14:105400489 NA 0.66 17.48 0.57 3.47e-56 Rheumatoid arthritis; BRCA cis rs798554 0.567 rs1182194 chr7:2868824 C/G cg18446336 chr7:2847575 GNA12 -0.35 -8.26 -0.31 8.65e-16 Height; BRCA cis rs72781680 1.000 rs12620594 chr2:24194490 G/A cg08917208 chr2:24149416 ATAD2B 0.93 13.82 0.48 3.34e-38 Lymphocyte counts; BRCA cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg02544614 chr20:61657117 NA 0.29 8.22 0.31 1.12e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.23e-19 Tonsillectomy; BRCA cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg20887711 chr4:1340912 KIAA1530 0.59 13.12 0.46 5.67e-35 Longevity; BRCA cis rs12477438 0.501 rs11688004 chr2:99735052 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 26.42 0.72 1.58e-104 Chronic sinus infection; BRCA cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg17971929 chr21:40555470 PSMG1 0.74 15.7 0.53 3.07e-47 Cognitive function; BRCA cis rs72781680 0.611 rs6720131 chr2:24364736 C/T cg06627628 chr2:24431161 ITSN2 -0.53 -8.38 -0.31 3.3e-16 Lymphocyte counts; BRCA cis rs67478160 0.595 rs67768834 chr14:104221085 C/G cg26031613 chr14:104095156 KLC1 -0.42 -8.37 -0.31 3.52e-16 Schizophrenia; BRCA cis rs61931739 0.534 rs11053020 chr12:34111092 C/G cg06521331 chr12:34319734 NA -0.61 -11.18 -0.4 1.2e-26 Morning vs. evening chronotype; BRCA cis rs11605275 1.000 rs11604179 chr11:20024759 G/A cg14835545 chr11:20032148 NAV2 -0.67 -9.25 -0.34 3.21e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs17818399 0.815 rs17768138 chr2:46868217 A/G cg02822958 chr2:46747628 ATP6V1E2 0.44 7.81 0.3 2.4e-14 Height; BRCA cis rs7727544 0.582 rs3805683 chr5:131535125 T/G cg14196790 chr5:131705035 SLC22A5 0.37 9.1 0.34 1.18e-18 Blood metabolite levels; BRCA cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg04450456 chr4:17643702 FAM184B -0.36 -9.37 -0.35 1.21e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1451375 0.652 rs7803788 chr7:50625898 A/G cg18232548 chr7:50535776 DDC -0.38 -8.05 -0.3 4.1e-15 Malaria; BRCA cis rs6060717 0.536 rs11697024 chr20:34546500 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.01 -0.3 5.63e-15 Hip circumference adjusted for BMI; BRCA cis rs17376456 0.569 rs10067754 chr5:93093110 T/A cg25358565 chr5:93447407 FAM172A 0.69 11.87 0.42 1.73e-29 Diabetic retinopathy; BRCA cis rs2011503 1.000 rs113527843 chr19:19643343 A/T cg11584989 chr19:19387371 SF4 0.64 13.48 0.47 1.25e-36 Bipolar disorder; BRCA cis rs796364 1.000 rs769950 chr2:200730028 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.7 11.83 0.42 2.57e-29 Schizophrenia; BRCA cis rs2066819 1.000 rs116849218 chr12:56683975 C/T cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA trans rs6951245 1.000 rs113575110 chr7:1084394 G/A cg13565492 chr6:43139072 SRF -0.79 -11.0 -0.4 6.8e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6912958 0.967 rs6905947 chr6:88161949 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.52 -10.48 -0.38 8.13e-24 Monocyte percentage of white cells; BRCA cis rs681343 1.000 rs679574 chr19:49206108 C/G cg12258179 chr19:49232187 RASIP1 -0.32 -7.81 -0.3 2.36e-14 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs1971762 0.522 rs10747680 chr12:54077776 T/G cg23533419 chr12:54090519 NA -0.33 -8.3 -0.31 6.05e-16 Height; BRCA cis rs2795502 1.000 rs1852959 chr10:43359636 T/C cg20628663 chr10:43360327 NA 0.71 13.83 0.48 3.04e-38 Blood protein levels; BRCA cis rs34779708 0.966 rs17591857 chr10:35499043 A/G cg03585969 chr10:35415529 CREM -0.49 -10.39 -0.38 1.84e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6060987 1 rs6060987 chr20:30427077 T/A cg13852791 chr20:30311386 BCL2L1 0.79 15.2 0.52 9.18e-45 Mean corpuscular volume; BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg07262247 chr5:131593730 PDLIM4 0.36 8.04 0.3 4.4e-15 Acylcarnitine levels; BRCA cis rs910316 0.737 rs175048 chr14:75479894 A/T cg23033748 chr14:75592666 NEK9 -0.34 -8.11 -0.31 2.64e-15 Height; BRCA cis rs7618915 0.547 rs10865973 chr3:52718154 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.92 0.4 1.38e-25 Bipolar disorder; BRCA cis rs7772486 0.754 rs6932863 chr6:146021255 A/T cg05347473 chr6:146136440 FBXO30 -0.42 -8.24 -0.31 9.99e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs17376456 0.825 rs28412976 chr5:93248377 T/C cg25358565 chr5:93447407 FAM172A 1.22 18.6 0.59 4.89e-62 Diabetic retinopathy; BRCA cis rs1008375 0.931 rs7672369 chr4:17604825 A/G cg15017067 chr4:17643749 FAM184B 0.29 9.0 0.34 2.56e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4629710 0.568 rs9492880 chr6:131565962 G/T cg12606694 chr6:131520996 AKAP7 0.49 10.43 0.38 1.21e-23 Multiple myeloma (IgH translocation); BRCA cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg02153584 chr22:29168773 CCDC117 0.54 11.1 0.4 2.68e-26 Lymphocyte counts; BRCA cis rs35123781 1.000 rs682164 chr5:139058589 A/G cg05227215 chr5:139057496 CXXC5 0.34 8.33 0.31 5e-16 Schizophrenia; BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.13 0.4 1.93e-26 Platelet count; BRCA cis rs34779708 0.966 rs7070427 chr10:35485689 A/T cg03585969 chr10:35415529 CREM 0.49 10.31 0.38 3.73e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3008870 0.920 rs3008860 chr1:67391003 G/C cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.49 0.65 1.62e-77 Lymphocyte percentage of white cells; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg00166722 chr3:10149974 C3orf24 0.56 11.16 0.4 1.5e-26 Alzheimer's disease; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 16.12 0.54 2.49e-49 Platelet count; BRCA cis rs7662987 0.517 rs2851263 chr4:100030354 A/G cg13256891 chr4:100009986 ADH5 0.53 9.79 0.36 3.62e-21 Smoking initiation; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg13732083 chr21:47605072 C21orf56 -0.39 -7.93 -0.3 9.86e-15 Testicular germ cell tumor; BRCA cis rs939658 0.805 rs35484723 chr15:79441032 A/G cg17916960 chr15:79447300 NA -0.43 -10.96 -0.4 9.69e-26 Refractive error; BRCA cis rs6684514 1.000 rs11264462 chr1:156241728 G/A cg16558208 chr1:156270281 VHLL 0.36 8.03 0.3 4.59e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2070488 0.804 rs4678605 chr3:38444489 T/A cg24069376 chr3:38537580 EXOG 0.32 8.93 0.33 4.53e-18 Electrocardiographic conduction measures; BRCA cis rs7582180 0.652 rs11687865 chr2:100947000 T/A cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA cis rs6772849 0.930 rs12630379 chr3:128370204 G/C cg16766828 chr3:128327626 NA -0.4 -8.86 -0.33 7.7e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs858239 0.601 rs7805206 chr7:23160210 C/T cg23682824 chr7:23144976 KLHL7 0.38 10.2 0.37 9.44e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs12291225 0.753 rs1431374 chr11:14303975 T/C cg19336497 chr11:14380999 RRAS2 -0.48 -11.94 -0.43 8.6e-30 Sense of smell; BRCA cis rs2832077 0.506 rs2832081 chr21:30152992 A/C cg08807101 chr21:30365312 RNF160 0.4 8.52 0.32 1.14e-16 Cognitive test performance; BRCA cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg24977027 chr2:88469347 THNSL2 0.56 9.38 0.35 1.12e-19 Plasma clusterin levels; BRCA cis rs832540 0.656 rs832567 chr5:56152416 C/A cg18230493 chr5:56204884 C5orf35 -0.43 -8.77 -0.33 1.61e-17 Coronary artery disease; BRCA cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg23583168 chr7:148888333 NA -0.79 -18.98 -0.6 4.88e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7246657 0.722 rs2909098 chr19:38204248 G/A cg14683738 chr19:37701593 ZNF585B -0.47 -8.04 -0.3 4.51e-15 Coronary artery calcification; BRCA cis rs9814567 0.806 rs2293294 chr3:134322814 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.54 16.54 0.55 2.16e-51 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.75 -13.3 -0.47 8.56e-36 Gut microbiome composition (summer); BRCA cis rs1003719 0.715 rs2252893 chr21:38507572 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs709400 0.633 rs7160208 chr14:103965528 G/A cg24130564 chr14:104152367 KLC1 -0.34 -7.91 -0.3 1.17e-14 Body mass index; BRCA cis rs11030122 0.673 rs4910590 chr11:4018619 C/T cg18678763 chr11:4115507 RRM1 -0.35 -7.85 -0.3 1.81e-14 Mean platelet volume;Platelet distribution width; BRCA trans rs2727020 0.675 rs1684258 chr11:49340020 G/A cg15704280 chr7:45808275 SEPT13 0.69 13.07 0.46 8.79e-35 Coronary artery disease; BRCA cis rs1011018 0.628 rs73158616 chr7:139438551 T/C cg03224163 chr7:139420300 HIPK2 -0.52 -9.03 -0.34 1.96e-18 Systolic blood pressure; BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.44 -8.88 -0.33 6.8e-18 Tonsillectomy; BRCA cis rs611744 0.503 rs13282220 chr8:109263043 T/C cg21045802 chr8:109455806 TTC35 0.38 8.01 0.3 5.38e-15 Dupuytren's disease; BRCA cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg24829409 chr8:58192753 C8orf71 -0.44 -8.67 -0.32 3.52e-17 Developmental language disorder (linguistic errors); BRCA cis rs72781680 0.898 rs72788302 chr2:24107246 C/T cg08917208 chr2:24149416 ATAD2B 1.12 15.82 0.53 7.88e-48 Lymphocyte counts; BRCA cis rs7666738 0.830 rs7662596 chr4:99019962 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.05 0.3 4.14e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs6854703 chr4:98977586 A/T cg05340658 chr4:99064831 C4orf37 0.66 16.1 0.54 3.26e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.501 rs6708878 chr2:99801564 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs4363385 0.818 rs6661791 chr1:152994113 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.88 -0.33 6.73e-18 Inflammatory skin disease; BRCA cis rs4819052 1.000 rs9984901 chr21:46663952 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.65 11.65 0.42 1.39e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg11608241 chr8:8085544 FLJ10661 0.33 9.19 0.34 5.32e-19 Parkinson's disease; BRCA cis rs13102973 0.965 rs6838419 chr4:135875682 T/C cg14419869 chr4:135874104 NA -0.59 -13.02 -0.46 1.53e-34 Subjective well-being; BRCA trans rs35110281 0.837 rs2838341 chr21:45076443 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.27 0.31 7.5e-16 Mean corpuscular volume; BRCA cis rs3784262 0.669 rs1061278 chr15:58246029 T/C cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.18 -0.37 1.15e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2712184 0.967 rs11892032 chr2:217668981 G/A cg05032264 chr2:217675019 NA -0.43 -10.73 -0.39 8.15e-25 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs1468333 1.000 rs2967784 chr5:137539239 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.56 0.32 8.09e-17 Resting heart rate; BRCA cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg23788917 chr6:8435910 SLC35B3 0.47 10.31 0.38 3.56e-23 Motion sickness; BRCA trans rs8062405 1.000 rs1987472 chr16:28825777 C/T cg09719594 chr16:21412588 NA -0.32 -8.0 -0.3 6.07e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7726839 0.561 rs4957050 chr5:579066 A/C cg09021430 chr5:549028 NA -0.64 -15.17 -0.51 1.26e-44 Obesity-related traits; BRCA cis rs71520386 0.530 rs10256628 chr7:22883259 G/C cg04907244 chr7:22894795 SNORD93 0.37 7.92 0.3 1.03e-14 Fibrinogen levels; BRCA cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs72781680 1.000 rs72788278 chr2:24095285 A/C cg20701182 chr2:24300061 SF3B14 0.57 8.95 0.33 3.98e-18 Lymphocyte counts; BRCA cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg00071950 chr4:10020882 SLC2A9 -0.46 -10.56 -0.39 3.93e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.61 -11.7 -0.42 9.09e-29 Gut microbiome composition (summer); BRCA cis rs1005277 0.602 rs1831315 chr10:38473353 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.42 -8.15 -0.31 1.92e-15 Extrinsic epigenetic age acceleration; BRCA cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.73 0.33 2.2e-17 Personality dimensions; BRCA cis rs7727544 0.571 rs12521097 chr5:131575338 G/A cg14196790 chr5:131705035 SLC22A5 0.4 10.49 0.38 7.4e-24 Blood metabolite levels; BRCA cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg17971929 chr21:40555470 PSMG1 -0.47 -10.28 -0.38 4.88e-23 Menarche (age at onset); BRCA cis rs473651 1.000 rs473651 chr2:239335401 A/C cg18131467 chr2:239335373 ASB1 0.96 35.03 0.81 7.62e-151 Multiple system atrophy; BRCA cis rs1862618 0.853 rs1423620 chr5:56100996 G/T cg18230493 chr5:56204884 C5orf35 -0.68 -13.49 -0.47 1.11e-36 Initial pursuit acceleration; BRCA trans rs57046232 0.552 rs6054184 chr20:6354592 A/G cg21095983 chr6:86352623 SYNCRIP 0.38 7.96 0.3 7.97e-15 Colorectal cancer; BRCA cis rs2346177 0.875 rs2166745 chr2:46646879 C/G cg02822958 chr2:46747628 ATP6V1E2 0.39 8.05 0.3 3.94e-15 HDL cholesterol; BRCA cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg01475735 chr3:40494733 NA 0.45 9.27 0.34 2.84e-19 Renal cell carcinoma; BRCA cis rs17270561 0.636 rs7453371 chr6:25719256 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.77 0.33 1.61e-17 Iron status biomarkers; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg21782813 chr7:2030301 MAD1L1 0.43 11.51 0.41 5.65e-28 Bipolar disorder and schizophrenia; BRCA cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg01579765 chr21:45077557 HSF2BP -0.39 -10.68 -0.39 1.34e-24 Mean corpuscular volume; BRCA cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg11058730 chr11:34937778 PDHX;APIP 0.72 16.99 0.56 1.03e-53 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6977660 1.000 rs7812001 chr7:19803323 A/G cg07541023 chr7:19748670 TWISTNB -0.44 -8.16 -0.31 1.85e-15 Thyroid stimulating hormone; BRCA cis rs4563143 0.514 rs73030738 chr19:29312328 G/A cg12667521 chr19:29218732 NA 0.47 7.92 0.3 1.07e-14 Methadone dose in opioid dependence; BRCA cis rs9309711 0.961 rs11692184 chr2:3480710 C/T cg16153549 chr2:3496821 NA -0.38 -9.03 -0.34 1.95e-18 Neurofibrillary tangles; BRCA cis rs534126 0.736 rs10239488 chr7:142949599 C/G cg22531018 chr7:142981779 TMEM139 0.48 10.82 0.39 3.44e-25 Cancer; BRCA cis rs12474201 0.925 rs17822294 chr2:46960004 G/A cg06386533 chr2:46925753 SOCS5 0.86 18.92 0.6 9.79e-64 Height; BRCA cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs765787 0.530 rs4775837 chr15:45537684 G/T cg24006582 chr15:45444508 DUOX1 -0.56 -11.55 -0.42 3.82e-28 Uric acid levels; BRCA cis rs6733011 0.508 rs4851173 chr2:99520608 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.25 -0.34 3.45e-19 Bipolar disorder; BRCA cis rs13136331 0.840 rs6857696 chr4:88701522 C/T cg22416721 chr4:88570574 DMP1 0.49 10.84 0.39 2.97e-25 Sitting height ratio; BRCA cis rs67478160 0.619 rs12886363 chr14:104273786 T/C cg08213375 chr14:104286397 PPP1R13B 0.61 16.09 0.54 3.93e-49 Schizophrenia; BRCA trans rs61931739 0.500 rs7312938 chr12:34378708 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.67 0.55 4.58e-52 Morning vs. evening chronotype; BRCA cis rs7590720 0.819 rs1344694 chr2:216893637 T/G cg12620499 chr2:216877984 MREG 0.82 24.71 0.7 4.09e-95 Alcohol dependence; BRCA cis rs3733585 0.660 rs13122290 chr4:9933832 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -13.12 -0.46 5.29e-35 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2880765 0.743 rs8028240 chr15:86013248 A/G cg10818794 chr15:86012489 AKAP13 -0.3 -8.27 -0.31 8.06e-16 Coronary artery disease; BRCA cis rs933688 1.000 rs2367526 chr5:90740525 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.1 0.62 5.33e-70 Smoking behavior; BRCA trans rs11098499 0.863 rs3822195 chr4:120471660 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA trans rs7824557 0.564 rs7839307 chr8:11198792 A/G cg06636001 chr8:8085503 FLJ10661 0.48 10.54 0.38 4.6e-24 Retinal vascular caliber; BRCA cis rs36051895 0.659 rs7036476 chr9:5063664 T/C cg02405213 chr9:5042618 JAK2 -0.5 -9.51 -0.35 3.77e-20 Pediatric autoimmune diseases; BRCA cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.69 -0.33 2.99e-17 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11890956 chr21:40555474 PSMG1 0.66 15.42 0.52 7.75e-46 Cognitive function; BRCA cis rs4481887 0.893 rs6681339 chr1:248482761 C/G cg00666640 chr1:248458726 OR2T12 0.31 8.73 0.33 2.19e-17 Common traits (Other); BRCA cis rs12493885 0.818 rs1713817 chr3:153872345 A/G cg17054900 chr3:154042577 DHX36 0.41 8.02 0.3 4.89e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs9329221 0.537 rs6986911 chr8:9978523 C/T cg15556689 chr8:8085844 FLJ10661 0.33 8.8 0.33 1.26e-17 Neuroticism; BRCA cis rs9649465 0.967 rs12531955 chr7:123377066 G/A cg04330084 chr7:123175371 IQUB -0.33 -8.88 -0.33 6.76e-18 Migraine; BRCA trans rs877282 0.945 rs12767287 chr10:787310 A/G cg22713356 chr15:30763199 NA 1.36 27.32 0.73 1.82e-109 Uric acid levels; BRCA cis rs7715811 1.000 rs7715811 chr5:13769974 C/T cg07548982 chr5:13769939 DNAH5 -0.39 -8.83 -0.33 9.9e-18 Subclinical atherosclerosis traits (other); BRCA cis rs1401999 0.650 rs3749445 chr3:183638506 C/T cg01324343 chr3:183735012 ABCC5 0.65 15.21 0.52 8.32e-45 Anterior chamber depth; BRCA trans rs6582630 0.555 rs11182217 chr12:38480030 G/A cg06521331 chr12:34319734 NA -0.48 -9.0 -0.34 2.54e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs9814567 0.896 rs58491661 chr3:134355189 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.2 0.31 1.28e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs9951602 0.512 rs12455591 chr18:76656028 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 17.83 0.58 5.16e-58 Obesity-related traits; BRCA trans rs9329221 0.527 rs4841351 chr8:10327367 G/A cg15556689 chr8:8085844 FLJ10661 -0.35 -9.08 -0.34 1.33e-18 Neuroticism; BRCA cis rs12477438 0.765 rs62154861 chr2:99590235 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.76 -18.97 -0.6 5.62e-64 Chronic sinus infection; BRCA cis rs2762353 0.808 rs1185978 chr6:25835895 A/G cg03517284 chr6:25882590 NA -0.51 -11.54 -0.42 4.09e-28 Blood metabolite levels; BRCA cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.85 20.83 0.64 6.07e-74 Birth weight; BRCA cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg25754956 chr12:51612065 POU6F1 0.84 17.1 0.56 3.08e-54 Cisplatin-induced ototoxicity; BRCA cis rs16866061 1.000 rs4674916 chr2:225365635 C/A cg12698349 chr2:225449008 CUL3 0.78 21.64 0.65 2.43e-78 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg00074818 chr8:8560427 CLDN23 0.38 8.44 0.32 2.08e-16 Obesity-related traits; BRCA cis rs6599388 0.803 rs11248057 chr4:906131 C/G cg07828340 chr4:882639 GAK 0.47 8.1 0.31 2.83e-15 Parkinson's disease; BRCA cis rs1577917 1.000 rs9647603 chr6:86639341 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.39 -0.41 1.77e-27 Response to antipsychotic treatment; BRCA cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg12373951 chr3:133503437 NA 0.47 10.97 0.4 8.9e-26 Iron status biomarkers; BRCA cis rs61931739 0.500 rs10844845 chr12:34381117 C/T cg06521331 chr12:34319734 NA -0.51 -10.17 -0.37 1.25e-22 Morning vs. evening chronotype; BRCA cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg11764359 chr7:65958608 NA -0.68 -15.19 -0.52 1.04e-44 Aortic root size; BRCA cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.34 0.35 1.63e-19 Body mass index; BRCA trans rs60843830 1.000 rs11553746 chr2:272203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.6 0.5 7.14e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg12698349 chr2:225449008 CUL3 -0.62 -13.51 -0.47 9.24e-37 IgE levels in asthmatics (D.p. specific); BRCA cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.07 0.37 3.16e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs7766436 0.614 rs16886471 chr6:22567379 C/T cg13666174 chr6:22585274 NA -0.41 -8.66 -0.32 3.86e-17 Coronary artery disease; BRCA cis rs2629540 1.000 rs2629540 chr10:126426148 G/C cg08799069 chr10:126477246 METTL10 0.51 9.74 0.36 5.45e-21 Cocaine dependence; BRCA cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.69e-23 Motion sickness; BRCA cis rs7412746 0.658 rs3768015 chr1:150812954 C/T cg18016565 chr1:150552671 MCL1 0.36 8.2 0.31 1.28e-15 Melanoma; BRCA cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg13119609 chr19:45449297 APOC2 0.47 13.08 0.46 8.51e-35 Blood protein levels; BRCA cis rs2559856 0.935 rs7970952 chr12:102081577 C/T cg12924262 chr12:102091054 CHPT1 0.36 8.12 0.31 2.42e-15 Blood protein levels; BRCA cis rs9527 0.590 rs1926037 chr10:104878010 A/C cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA cis rs1941023 0.584 rs7935082 chr11:60155000 T/C cg08716584 chr11:60157161 MS4A7 -0.43 -10.46 -0.38 9.28e-24 Congenital heart disease (maternal effect); BRCA cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg02891314 chr5:179741120 GFPT2 -0.67 -13.48 -0.47 1.23e-36 Height; BRCA cis rs17270561 0.553 rs6456696 chr6:25741408 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg10932868 chr11:921992 NA 0.39 9.35 0.35 1.48e-19 Alzheimer's disease (late onset); BRCA cis rs1595825 0.891 rs4491721 chr2:198521407 C/G cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.91e-15 Ulcerative colitis; BRCA cis rs2652834 1.000 rs2729782 chr15:63403354 G/C cg05507819 chr15:63340323 TPM1 0.45 8.26 0.31 8.19e-16 HDL cholesterol; BRCA cis rs9368481 0.761 rs3931464 chr6:26939856 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.24 0.31 9.94e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg18016565 chr1:150552671 MCL1 -0.41 -9.39 -0.35 1.07e-19 Blood protein levels; BRCA cis rs1065852 0.526 rs8138080 chr22:42396371 A/G cg22189786 chr22:42395067 WBP2NL -0.42 -8.3 -0.31 6.05e-16 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs8141529 0.711 rs5752797 chr22:29179998 C/T cg02153584 chr22:29168773 CCDC117 0.46 8.16 0.31 1.73e-15 Lymphocyte counts; BRCA cis rs6977660 0.660 rs61670426 chr7:19790460 A/G cg05791153 chr7:19748676 TWISTNB 0.57 10.38 0.38 2.03e-23 Thyroid stimulating hormone; BRCA cis rs1577917 1.000 rs117907570 chr6:86601283 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.4 -10.93 -0.4 1.32e-25 Response to antipsychotic treatment; BRCA cis rs1577917 0.958 rs10944136 chr6:86448499 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.25 -0.44 3.84e-31 Response to antipsychotic treatment; BRCA cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg05868516 chr6:26286170 HIST1H4H 0.5 11.25 0.41 6.6e-27 Educational attainment; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg09877947 chr5:131593287 PDLIM4 -0.48 -12.25 -0.44 3.88e-31 Acylcarnitine levels; BRCA cis rs2032447 0.802 rs199755 chr6:25990367 G/A cg18357526 chr6:26021779 HIST1H4A 0.44 8.02 0.3 4.93e-15 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.46 -9.2 -0.34 5.1e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2625529 0.526 rs6494997 chr15:72560642 C/T cg16672083 chr15:72433130 SENP8 0.61 14.64 0.5 4.47e-42 Red blood cell count; BRCA cis rs2832191 0.791 rs2832197 chr21:30497790 T/C cg24692254 chr21:30365293 RNF160 -0.62 -15.86 -0.53 5.22e-48 Dental caries; BRCA cis rs9649213 0.593 rs62478233 chr7:98023092 T/C cg21770322 chr7:97807741 LMTK2 0.43 11.34 0.41 2.83e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs17685 0.725 rs6467993 chr7:75719350 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 27.65 0.74 2.75e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg11764359 chr7:65958608 NA -0.8 -19.57 -0.61 3.39e-67 Aortic root size; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg23708337 chr7:1209742 NA 0.63 8.84 0.33 8.9e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7829975 0.711 rs12682352 chr8:8646246 A/G cg08975724 chr8:8085496 FLJ10661 0.42 9.36 0.35 1.32e-19 Mood instability; BRCA cis rs7927771 0.524 rs10838739 chr11:47672743 A/G cg20307385 chr11:47447363 PSMC3 -0.42 -9.65 -0.36 1.16e-20 Subjective well-being; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.6 -11.35 -0.41 2.6e-27 Alzheimer's disease; BRCA trans rs11098499 0.954 rs9998585 chr4:120396802 T/A cg25214090 chr10:38739885 LOC399744 0.54 12.23 0.44 4.84e-31 Corneal astigmatism; BRCA cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg02527881 chr3:46936655 PTH1R -0.38 -9.28 -0.34 2.51e-19 Colorectal cancer; BRCA cis rs3749237 0.964 rs13084243 chr3:49821878 G/C cg03060546 chr3:49711283 APEH 0.52 10.85 0.39 2.8e-25 Resting heart rate; BRCA cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg26408565 chr15:76604113 ETFA -0.48 -10.3 -0.38 3.92e-23 Blood metabolite levels; BRCA trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg15556689 chr8:8085844 FLJ10661 -0.34 -8.92 -0.33 4.94e-18 Neuroticism; BRCA cis rs7552404 1.000 rs12126607 chr1:76217097 G/A cg22875332 chr1:76189707 ACADM 0.7 15.05 0.51 4.65e-44 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs561341 0.556 rs542244 chr17:30307242 T/C cg20587970 chr11:113659929 NA -1.19 -21.91 -0.65 9e-80 Hip circumference adjusted for BMI; BRCA cis rs2439831 0.850 rs12442297 chr15:44168470 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.73 12.39 0.44 9.22e-32 Lung cancer in ever smokers; BRCA cis rs10927875 0.518 rs945416 chr1:16344402 G/A cg06159980 chr1:16340746 HSPB7 -0.38 -8.74 -0.33 1.98e-17 Dilated cardiomyopathy; BRCA cis rs72615157 0.561 rs113844570 chr7:99873778 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.61 9.23 0.34 4.03e-19 Lung function (FEV1/FVC); BRCA cis rs8072100 0.701 rs6503807 chr17:45772932 T/C cg19784903 chr17:45786737 TBKBP1 -0.46 -11.16 -0.4 1.52e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9467773 0.967 rs6924865 chr6:26521353 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.19 0.58 6.45e-60 Intelligence (multi-trait analysis); BRCA cis rs908922 0.676 rs491077 chr1:152519570 C/A cg20991723 chr1:152506922 NA 0.37 8.32 0.31 5.36e-16 Hair morphology; BRCA cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg00152838 chr16:24741724 TNRC6A -0.36 -7.98 -0.3 6.88e-15 Intelligence (multi-trait analysis); BRCA cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs11190604 1.000 rs7071271 chr10:102264824 G/A cg07080220 chr10:102295463 HIF1AN 0.61 14.37 0.49 8.44e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6973256 0.897 rs2991242 chr7:133336459 A/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.87 -0.33 7.24e-18 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs10789479 chr1:46352500 T/C cg06784218 chr1:46089804 CCDC17 0.49 11.68 0.42 1.08e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10751667 0.961 rs10902263 chr11:992691 A/C cg06064525 chr11:970664 AP2A2 0.32 9.43 0.35 7.33e-20 Alzheimer's disease (late onset); BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg00814883 chr7:100076585 TSC22D4 -0.54 -11.49 -0.41 6.45e-28 Platelet count; BRCA cis rs752010 0.811 rs10749836 chr1:42086860 G/C cg06885757 chr1:42089581 HIVEP3 0.24 8.65 0.32 4.31e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9304742 1.000 rs9304742 chr19:53451291 A/G cg09915433 chr19:53449742 NA -0.77 -18.64 -0.59 2.83e-62 Psoriasis; BRCA cis rs7917772 0.636 rs4919674 chr10:104522226 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.6 -0.39 2.74e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.753 rs7657644 chr4:99057734 T/A cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2070488 0.965 rs2126534 chr3:38445165 T/G cg24069376 chr3:38537580 EXOG 0.4 11.33 0.41 3.12e-27 Electrocardiographic conduction measures; BRCA cis rs9311474 0.508 rs4687546 chr3:52605943 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.51 0.44 2.88e-32 Electroencephalogram traits; BRCA cis rs614226 1.000 rs591992 chr12:121019323 T/C cg27489772 chr12:121021490 NA 0.45 8.03 0.3 4.74e-15 Type 1 diabetes nephropathy; BRCA cis rs3820928 1.000 rs4675115 chr2:227769123 C/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.31 -0.31 5.7e-16 Pulmonary function; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg04025307 chr7:1156635 C7orf50 0.47 9.31 0.35 2.06e-19 Bronchopulmonary dysplasia; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs17270561 0.514 rs10946805 chr6:26077891 C/T cg16482183 chr6:26056742 HIST1H1C 0.96 19.06 0.6 1.77e-64 Iron status biomarkers; BRCA cis rs12618769 0.652 rs3820941 chr2:99233781 C/T cg10123293 chr2:99228465 UNC50 0.42 8.17 0.31 1.66e-15 Bipolar disorder; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg03188948 chr7:1209495 NA 0.48 9.89 0.36 1.53e-21 Longevity;Endometriosis; BRCA cis rs79057730 0.599 rs79272827 chr7:807015 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.74 10.24 0.38 6.77e-23 Initial pursuit acceleration; BRCA cis rs9325144 0.532 rs1352121 chr12:39130696 A/G cg26384229 chr12:38710491 ALG10B -0.45 -10.91 -0.4 1.54e-25 Morning vs. evening chronotype; BRCA cis rs17711722 0.585 rs6942660 chr7:65302406 C/T cg11764359 chr7:65958608 NA 0.62 13.55 0.47 6.08e-37 Calcium levels; BRCA cis rs2710642 0.815 rs6545971 chr2:63074986 A/T cg17519650 chr2:63277830 OTX1 0.39 8.6 0.32 6.25e-17 LDL cholesterol levels;LDL cholesterol; BRCA cis rs17253792 0.598 rs71413578 chr14:56018651 T/C cg01858014 chr14:56050164 KTN1 -0.61 -7.94 -0.3 9.14e-15 Putamen volume; BRCA cis rs911555 0.570 rs11625397 chr14:104027557 A/G cg26031613 chr14:104095156 KLC1 -0.61 -13.24 -0.46 1.53e-35 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs11932942 chr4:98998939 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7520050 0.933 rs11211203 chr1:46315592 A/G cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.37e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7666738 0.791 rs10005118 chr4:99038196 A/C cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.12e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.722 rs17595727 chr4:120262074 C/T cg25214090 chr10:38739885 LOC399744 -0.42 -9.77 -0.36 4.06e-21 Corneal astigmatism; BRCA cis rs2130392 1.000 rs11132254 chr4:185611592 G/T cg04058563 chr4:185651563 MLF1IP 0.37 8.89 0.33 5.99e-18 Kawasaki disease; BRCA cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg14784868 chr12:69753453 YEATS4 0.66 18.61 0.59 4.31e-62 Blood protein levels; BRCA cis rs7301016 0.846 rs11174571 chr12:63022329 C/T cg11441379 chr12:63026424 NA 0.49 8.95 0.33 3.98e-18 IgG glycosylation; BRCA cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg01028140 chr2:1542097 TPO -0.58 -11.89 -0.43 1.35e-29 IgG glycosylation; BRCA cis rs7103648 0.864 rs10742802 chr11:47432725 T/G cg03711944 chr11:47377212 SPI1 -0.42 -11.33 -0.41 2.93e-27 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6840360 0.615 rs1561917 chr4:152479233 G/A cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 5.82e-15 Intelligence (multi-trait analysis); BRCA cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg14983838 chr19:29218262 NA 0.54 10.07 0.37 2.97e-22 Methadone dose in opioid dependence; BRCA cis rs9660992 0.590 rs1779411 chr1:205238530 C/T cg00857998 chr1:205179979 DSTYK 0.44 8.36 0.31 3.95e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs10465746 0.780 rs11163867 chr1:84384847 C/T cg10977910 chr1:84465055 TTLL7 0.58 12.09 0.43 1.92e-30 Obesity-related traits; BRCA cis rs12617721 0.681 rs10190015 chr2:99018717 A/G cg10123293 chr2:99228465 UNC50 0.49 8.99 0.33 2.87e-18 Bipolar disorder with mood-incongruent psychosis; BRCA trans rs12517041 0.872 rs78861527 chr5:23283534 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA cis rs7493 0.755 rs34774523 chr7:94962142 G/A cg19678392 chr7:94953810 PON1 -0.41 -8.52 -0.32 1.17e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7249142 0.549 rs12975253 chr19:19279745 A/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.48 -0.32 1.51e-16 IgG glycosylation; BRCA cis rs10782582 0.593 rs17647178 chr1:76210524 A/G cg03433033 chr1:76189801 ACADM -0.48 -10.2 -0.37 9.42e-23 Daytime sleep phenotypes; BRCA cis rs2762353 0.935 rs1165153 chr6:25817789 A/G cg03264133 chr6:25882463 NA -0.49 -11.01 -0.4 6.3e-26 Blood metabolite levels; BRCA cis rs11792861 0.890 rs2900481 chr9:111831825 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.19 0.31 1.44e-15 Menarche (age at onset); BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg00166722 chr3:10149974 C3orf24 0.57 10.99 0.4 7.79e-26 Alzheimer's disease; BRCA cis rs735396 0.770 rs2259820 chr12:121435342 C/T cg02403541 chr12:121454288 C12orf43 0.64 12.1 0.43 1.76e-30 N-glycan levels; BRCA cis rs67460515 0.892 rs13073147 chr3:161045237 T/C cg03342759 chr3:160939853 NMD3 -0.81 -19.0 -0.6 3.77e-64 Parkinson's disease; BRCA cis rs72781680 0.898 rs17762609 chr2:24114729 G/T cg08917208 chr2:24149416 ATAD2B 0.93 13.78 0.48 5.46e-38 Lymphocyte counts; BRCA cis rs8072100 0.846 rs4264433 chr17:45737275 A/T cg25173405 chr17:45401733 C17orf57 0.51 10.74 0.39 7.58e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs853679 0.607 rs67101035 chr6:27798887 C/G cg01620082 chr3:125678407 NA -0.91 -10.37 -0.38 2.19e-23 Depression; BRCA cis rs61935443 0.832 rs11107771 chr12:95276844 A/G cg21533806 chr12:95267307 NA 0.46 8.92 0.33 4.94e-18 Schizophrenia; BRCA cis rs4595586 0.545 rs2388175 chr12:39389217 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.31e-19 Morning vs. evening chronotype; BRCA cis rs2404602 0.536 rs17364330 chr15:76765385 A/T cg23625390 chr15:77176239 SCAPER 0.35 7.98 0.3 6.93e-15 Blood metabolite levels; BRCA cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg21475434 chr5:93447410 FAM172A 0.64 8.55 0.32 9.13e-17 Diabetic retinopathy; BRCA cis rs17641971 0.684 rs7835336 chr8:49957895 A/G cg00325661 chr8:49890786 NA 0.38 10.51 0.38 6.06e-24 Blood metabolite levels; BRCA cis rs17270561 0.609 rs9379785 chr6:25726213 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs10501293 1.000 rs2114087 chr11:43133002 G/C cg03447554 chr11:43094025 NA -0.47 -8.76 -0.33 1.71e-17 Cognitive performance; BRCA cis rs4713118 0.666 rs2893930 chr6:27738806 T/C cg20933634 chr6:27740509 NA 0.47 8.87 0.33 7.41e-18 Parkinson's disease; BRCA cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs1218582 0.772 rs12069356 chr1:154849771 C/T cg16680214 chr1:154839983 KCNN3 -0.43 -12.06 -0.43 2.56e-30 Prostate cancer; BRCA cis rs11190604 1.000 rs74650218 chr10:102293830 C/T cg07080220 chr10:102295463 HIF1AN 0.63 14.73 0.5 1.65e-42 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7267979 0.866 rs2424698 chr20:25256106 C/T cg08601574 chr20:25228251 PYGB 0.4 9.21 0.34 4.79e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs30380 1.000 rs469758 chr5:96121715 C/T cg16492584 chr5:96139282 ERAP1 -0.31 -7.88 -0.3 1.46e-14 Cerebrospinal fluid biomarker levels; BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg04944784 chr2:26401820 FAM59B -0.85 -13.17 -0.46 3.18e-35 Gut microbiome composition (summer); BRCA cis rs6964587 0.626 rs6979235 chr7:91511776 T/C cg17063962 chr7:91808500 NA -0.55 -12.72 -0.45 3.49e-33 Breast cancer; BRCA cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg06453172 chr10:134556979 INPP5A -0.6 -11.86 -0.42 1.78e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10927875 0.894 rs10927878 chr1:16319957 C/T cg21385522 chr1:16154831 NA -0.52 -10.22 -0.37 8.51e-23 Dilated cardiomyopathy; BRCA cis rs801193 0.569 rs4717315 chr7:66178325 C/T cg18876405 chr7:65276391 NA 0.48 10.74 0.39 7.45e-25 Aortic root size; BRCA cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs61931739 0.534 rs1844526 chr12:34102780 G/A cg06521331 chr12:34319734 NA -0.62 -11.18 -0.4 1.22e-26 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.48 0.38 7.72e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7737355 0.947 rs1422871 chr5:130942481 G/A cg06307176 chr5:131281290 NA 0.54 10.56 0.39 3.96e-24 Life satisfaction; BRCA cis rs754466 0.580 rs1344966 chr10:79534527 T/C cg17075019 chr10:79541650 NA -0.84 -20.92 -0.64 1.99e-74 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs3849570 0.732 rs11715625 chr3:81875938 A/T cg07356753 chr3:81810745 GBE1 -0.4 -9.64 -0.36 1.29e-20 Waist circumference;Body mass index; BRCA cis rs7737355 0.812 rs40991 chr5:131000654 C/A cg06307176 chr5:131281290 NA 0.53 10.41 0.38 1.51e-23 Life satisfaction; BRCA cis rs6429082 0.818 rs291381 chr1:235641924 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 14.15 0.49 9.77e-40 Adiposity; BRCA cis rs55883249 0.957 rs62119393 chr2:9718247 C/T cg23886495 chr2:9695866 ADAM17 0.56 8.19 0.31 1.45e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA trans rs9944715 0.954 rs6507677 chr18:43762557 T/C cg01718231 chr17:29326311 RNF135 0.47 9.46 0.35 5.62e-20 Red cell distribution width;Mean corpuscular volume; BRCA trans rs853679 0.546 rs2232426 chr6:28360659 G/C cg01620082 chr3:125678407 NA -0.97 -11.01 -0.4 6.21e-26 Depression; BRCA cis rs7267979 1.000 rs6037086 chr20:25306338 A/G cg08601574 chr20:25228251 PYGB -0.39 -9.0 -0.34 2.64e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.723 rs35327100 chr4:98977788 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA cis rs208520 0.955 rs208532 chr6:66961280 T/A cg07460842 chr6:66804631 NA -0.86 -14.32 -0.49 1.47e-40 Exhaled nitric oxide output; BRCA cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg06618935 chr21:46677482 NA 0.38 8.49 0.32 1.43e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6570726 0.935 rs447818 chr6:145868996 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.65 0.5 4.04e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs9296092 0.538 rs7761268 chr6:33519300 C/T cg13560919 chr6:33536144 NA -0.85 -18.62 -0.59 3.9e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs10504229 1.000 rs72652905 chr8:58188355 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -12.09 -0.43 1.86e-30 Developmental language disorder (linguistic errors); BRCA cis rs1878931 0.501 rs4785934 chr16:3419934 G/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 12.08 0.43 2.1000000000000002e-30 Body mass index (adult); BRCA cis rs1829883 1.000 rs2461971 chr5:98777650 A/G cg08333243 chr5:99726346 NA -0.37 -8.81 -0.33 1.18e-17 Hemostatic factors and hematological phenotypes; BRCA cis rs17253792 0.732 rs10146604 chr14:56045770 C/G cg01858014 chr14:56050164 KTN1 -0.79 -11.43 -0.41 1.15e-27 Putamen volume; BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA trans rs11039798 0.545 rs7118670 chr11:48532056 C/T cg03929089 chr4:120376271 NA 0.5 8.33 0.31 5.1e-16 Axial length; BRCA cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg10802521 chr3:52805072 NEK4 -0.31 -8.18 -0.31 1.57e-15 Bipolar disorder; BRCA cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg21644426 chr2:191273491 MFSD6 -0.43 -11.02 -0.4 5.42e-26 Pulse pressure; BRCA cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg08085267 chr17:45401833 C17orf57 -0.63 -13.56 -0.47 5.45e-37 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs17270561 0.636 rs1165216 chr6:25797971 G/A cg16482183 chr6:26056742 HIST1H1C 0.41 8.78 0.33 1.49e-17 Iron status biomarkers; BRCA cis rs7917772 0.582 rs7087984 chr10:104380686 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 13.98 0.48 6.3e-39 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs514406 0.708 rs546334 chr1:53326210 T/C cg25767906 chr1:53392781 SCP2 -0.47 -10.37 -0.38 2.22e-23 Monocyte count; BRCA cis rs7584330 0.554 rs80151891 chr2:238398826 G/T cg08992911 chr2:238395768 MLPH 0.6 10.16 0.37 1.38e-22 Prostate cancer; BRCA cis rs703842 0.585 rs10877022 chr12:58223937 A/G cg00677455 chr12:58241039 CTDSP2 0.74 18.02 0.58 5.5e-59 Multiple sclerosis; BRCA cis rs7917772 0.545 rs3934960 chr10:104355275 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.66 -0.48 1.87e-37 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13118159 0.836 rs2293630 chr4:1342521 G/A cg01939980 chr4:1354348 KIAA1530 0.39 10.93 0.4 1.34e-25 Longevity; BRCA cis rs4478858 0.647 rs4949380 chr1:31764160 A/G cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs6772849 0.896 rs9816260 chr3:128352083 A/T cg16766828 chr3:128327626 NA -0.39 -8.71 -0.33 2.64e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs6426558 0.537 rs7512409 chr1:227484038 A/G cg10327440 chr1:227177885 CDC42BPA -0.47 -9.43 -0.35 7.73e-20 Neutrophil percentage of white cells; BRCA cis rs10911232 0.507 rs10797829 chr1:183033228 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.65 -16.85 -0.55 5.56e-53 Hypertriglyceridemia; BRCA trans rs4596713 0.538 rs10781440 chr9:71762766 A/G cg16512924 chr15:28394682 HERC2 -0.42 -9.86 -0.36 1.94e-21 Headache; BRCA cis rs2404602 0.684 rs965818 chr15:76866785 T/C cg23625390 chr15:77176239 SCAPER -0.55 -14.06 -0.49 2.7e-39 Blood metabolite levels; BRCA cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg26248373 chr2:1572462 NA -0.51 -9.5 -0.35 4.05e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg06766960 chr11:133703094 NA 0.51 10.0 0.37 5.75e-22 Childhood ear infection; BRCA cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg26384229 chr12:38710491 ALG10B 0.64 14.93 0.51 1.8e-43 Bladder cancer; BRCA cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg26373071 chr5:1325741 CLPTM1L 0.49 12.09 0.43 1.98e-30 Lung cancer; BRCA cis rs2625529 0.641 rs11852789 chr15:72265494 G/C cg16672083 chr15:72433130 SENP8 -0.85 -17.56 -0.57 1.2e-56 Red blood cell count; BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg11905131 chr22:24372483 LOC391322 -0.45 -9.78 -0.36 3.71e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1030877 0.515 rs3828300 chr2:105901107 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.62 -11.14 -0.4 1.88e-26 Obesity-related traits; BRCA cis rs897080 0.552 rs698793 chr2:44685685 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.2 0.34 4.85e-19 Height; BRCA cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.63e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7527798 0.614 rs1830762 chr1:207874272 A/G cg21110645 chr1:207815933 NA 0.28 8.18 0.31 1.59e-15 Erythrocyte sedimentation rate; BRCA cis rs1707322 0.686 rs2275085 chr1:46085852 C/T cg03146154 chr1:46216737 IPP -0.5 -11.2 -0.41 9.99e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12497850 0.897 rs9850134 chr3:48957147 A/G cg07636037 chr3:49044803 WDR6 0.97 29.41 0.76 6.97e-121 Parkinson's disease; BRCA cis rs10464366 0.614 rs62442213 chr7:39146933 C/T cg15212455 chr7:39170539 POU6F2 0.48 10.62 0.39 2.16e-24 IgG glycosylation; BRCA cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.02 0.43 3.79e-30 Multiple sclerosis; BRCA cis rs700651 0.752 rs7592556 chr2:198891021 G/A cg00792783 chr2:198669748 PLCL1 0.43 9.56 0.35 2.43e-20 Intracranial aneurysm; BRCA cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg21918786 chr6:109611834 NA -0.44 -11.95 -0.43 7.9e-30 Reticulocyte fraction of red cells; BRCA cis rs9341808 0.683 rs7771449 chr6:80919977 C/T cg08355045 chr6:80787529 NA 0.39 9.83 0.36 2.45e-21 Sitting height ratio; BRCA cis rs13256369 1.000 rs10103769 chr8:8573036 G/T cg18904891 chr8:8559673 CLDN23 0.61 12.14 0.43 1.19e-30 Obesity-related traits; BRCA trans rs2204008 0.807 rs10880234 chr12:38318353 C/T cg06521331 chr12:34319734 NA -0.47 -8.35 -0.31 4.12e-16 Bladder cancer; BRCA cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg14349672 chr11:133703707 NA -0.42 -9.17 -0.34 6.16e-19 Childhood ear infection; BRCA cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg06550200 chr5:1325588 CLPTM1L -0.6 -12.42 -0.44 6.85e-32 Lung cancer; BRCA trans rs6951245 1.000 rs2363286 chr7:1091625 A/G cg13565492 chr6:43139072 SRF -0.7 -9.93 -0.37 1.09e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10465746 0.658 rs980418 chr1:84365653 T/G cg10977910 chr1:84465055 TTLL7 0.59 12.66 0.45 6.17e-33 Obesity-related traits; BRCA cis rs13223928 0.536 rs12700594 chr7:3156701 G/A cg19214707 chr7:3157722 NA 0.45 11.32 0.41 3.46e-27 Eosinophil percentage of white cells;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil counts; BRCA trans rs6479891 0.818 rs9415700 chr10:65145565 C/T cg14819942 chr15:35414228 NA 0.36 8.77 0.33 1.57e-17 Arthritis (juvenile idiopathic); BRCA cis rs992157 0.764 rs2015863 chr2:219185161 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.47 -9.3 -0.35 2.13e-19 Colorectal cancer; BRCA cis rs1865760 0.786 rs1436308 chr6:25939567 T/G cg17691542 chr6:26056736 HIST1H1C 0.48 9.84 0.36 2.36e-21 Height; BRCA cis rs2249625 0.844 rs1830339 chr6:72877600 G/A cg18830697 chr6:72922368 RIMS1 -0.38 -8.18 -0.31 1.49e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA trans rs208520 0.690 rs207082 chr6:66773796 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.08 -0.64 2.77e-75 Exhaled nitric oxide output; BRCA cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg18904891 chr8:8559673 CLDN23 0.65 12.91 0.45 4.83e-34 Obesity-related traits; BRCA cis rs9381107 0.932 rs34030781 chr6:9451449 C/T cg14735645 chr6:9486422 NA -0.45 -7.92 -0.3 1.09e-14 Nonsyndromic cleft lip with cleft palate; BRCA cis rs4820539 1.000 rs4822360 chr22:23482460 A/G cg14186256 chr22:23484241 RTDR1 0.74 21.07 0.64 3.24e-75 Bone mineral density; BRCA cis rs1448094 0.648 rs10863093 chr12:86285792 T/G cg19622623 chr12:86230825 RASSF9 -0.29 -8.14 -0.31 2.01e-15 Major depressive disorder; BRCA cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg04455712 chr21:45112962 RRP1B 0.4 10.28 0.38 4.82e-23 Mean corpuscular volume; BRCA cis rs12617721 0.874 rs3754890 chr2:99088624 C/T cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.29 -0.41 4.4e-27 Schizophrenia; BRCA cis rs250677 0.522 rs1432798 chr5:148383345 C/G cg18129178 chr5:148520854 ABLIM3 -0.49 -9.71 -0.36 6.89e-21 Breast cancer; BRCA trans rs629535 0.773 rs630235 chr8:70033529 T/G cg21567404 chr3:27674614 NA 1.0 20.78 0.64 1.15e-73 Dupuytren's disease; BRCA trans rs11098499 0.866 rs12374244 chr4:120281972 A/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs6582630 0.576 rs4882372 chr12:38356609 C/A cg26384229 chr12:38710491 ALG10B -0.43 -9.95 -0.37 8.7e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs509477 0.962 rs562412 chr18:32576305 T/C cg23791764 chr18:32556832 MAPRE2 -0.35 -8.26 -0.31 8.55e-16 Cerebrospinal fluid AB1-42 levels; BRCA cis rs4974559 0.690 rs28515563 chr4:1315123 G/A cg02980000 chr4:1222292 CTBP1 0.81 13.29 0.47 9.29e-36 Systolic blood pressure; BRCA cis rs17270561 0.609 rs6941933 chr6:25745702 T/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.79 0.33 1.39e-17 Iron status biomarkers; BRCA cis rs7072216 0.770 rs1739 chr10:100176339 A/G cg26618903 chr10:100175079 PYROXD2 -0.27 -8.06 -0.3 3.65e-15 Metabolite levels; BRCA cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.51 -0.38 5.89e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10782582 0.609 rs2029682 chr1:76341619 T/C cg03433033 chr1:76189801 ACADM -0.42 -8.55 -0.32 9.23e-17 Daytime sleep phenotypes; BRCA cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg21782813 chr7:2030301 MAD1L1 0.39 10.87 0.39 2.32e-25 Bipolar disorder and schizophrenia; BRCA cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg13175981 chr1:150552382 MCL1 0.53 11.77 0.42 4.36e-29 Tonsillectomy; BRCA cis rs75557865 1 rs75557865 chr3:121652141 G/A cg20356878 chr3:121714668 ILDR1 0.43 10.08 0.37 2.81e-22 Allergic disease (asthma, hay fever or eczema); BRCA cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg18016565 chr1:150552671 MCL1 0.36 8.68 0.32 3.35e-17 Urate levels; BRCA cis rs4853012 0.838 rs72911122 chr2:74344119 C/G cg20891558 chr2:74357851 NA 0.51 12.13 0.43 1.26e-30 Gestational age at birth (maternal effect); BRCA cis rs6582630 0.537 rs10785436 chr12:38461040 G/C cg13010199 chr12:38710504 ALG10B 0.45 9.49 0.35 4.33e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs7020830 0.861 rs13295981 chr9:37330067 C/T cg14294708 chr9:37120828 ZCCHC7 1.17 41.64 0.85 3.28e-184 Schizophrenia; BRCA cis rs11718455 0.960 rs34241796 chr3:44000394 A/T cg08738300 chr3:44038990 NA 0.44 8.5 0.32 1.31e-16 Coronary artery disease; BRCA cis rs1153858 1.000 rs4775937 chr15:45678614 C/A cg14582100 chr15:45693742 SPATA5L1 0.37 11.81 0.42 3.07e-29 Homoarginine levels; BRCA cis rs7598759 0.712 rs6740474 chr2:232331831 A/G cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.1e-14 Noise-induced hearing loss; BRCA cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg24296786 chr1:45957014 TESK2 -0.56 -13.15 -0.46 3.9e-35 High light scatter reticulocyte count; BRCA cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 22.79 0.67 1.39e-84 Chronic sinus infection; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg05863683 chr7:1912471 MAD1L1 0.44 9.89 0.36 1.45e-21 Bipolar disorder and schizophrenia; BRCA cis rs17092148 0.887 rs6142199 chr20:33162298 G/C cg16810054 chr20:33298113 TP53INP2 -0.44 -10.21 -0.37 8.76e-23 Neuroticism; BRCA cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.42 -9.14 -0.34 8.22e-19 IgG glycosylation; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg11766577 chr21:47581405 C21orf56 0.49 10.68 0.39 1.3e-24 Testicular germ cell tumor; BRCA cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs847577 0.677 rs4729403 chr7:97707841 G/C cg21770322 chr7:97807741 LMTK2 -0.45 -12.37 -0.44 1.16e-31 Breast cancer; BRCA cis rs17401966 1.000 rs1049887 chr1:10460485 T/C cg03954927 chr1:10346856 KIF1B 0.45 11.97 0.43 6.06e-30 Hepatocellular carcinoma; BRCA cis rs172166 0.611 rs203883 chr6:28078356 A/G cg10876282 chr6:28092338 ZSCAN16 0.42 8.3 0.31 6.43e-16 Cardiac Troponin-T levels; BRCA cis rs2041840 0.538 rs6708524 chr2:37572687 C/T cg25727520 chr2:37576821 QPCT -0.28 -7.91 -0.3 1.17e-14 Chronic lymphocytic leukemia; BRCA cis rs9287719 0.686 rs10174605 chr2:10725232 G/A cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs7945705 0.875 rs4929914 chr11:8824388 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -10.9 -0.4 1.71e-25 Hemoglobin concentration; BRCA trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg15704280 chr7:45808275 SEPT13 -0.53 -10.26 -0.38 5.58e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs4478858 0.735 rs12134484 chr1:31823741 G/A cg00250761 chr1:31883323 NA -0.32 -8.47 -0.32 1.7e-16 Alcohol dependence; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11905131 chr22:24372483 LOC391322 -0.53 -12.12 -0.43 1.47e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9814567 1.000 rs11927068 chr3:134266321 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg10729496 chr3:10149963 C3orf24 0.49 9.26 0.34 3.05e-19 Alzheimer's disease; BRCA cis rs12711979 0.509 rs10200764 chr2:3827772 C/G cg17052675 chr2:3827356 NA -0.71 -24.21 -0.69 2.14e-92 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg23708337 chr7:1209742 NA 0.55 11.82 0.42 2.78e-29 Longevity;Endometriosis; BRCA cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25622487 chr11:95524042 FAM76B;CEP57 0.78 18.8 0.6 4.4e-63 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg11644478 chr21:40555479 PSMG1 -0.48 -10.03 -0.37 4.5e-22 Menarche (age at onset); BRCA cis rs9368481 0.594 rs7768643 chr6:26891919 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 0.23 7.96 0.3 8.14e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6121246 0.559 rs12479491 chr20:30265450 T/C cg13852791 chr20:30311386 BCL2L1 0.96 23.14 0.68 1.63e-86 Mean corpuscular hemoglobin; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg23131131 chr22:24373011 LOC391322 -0.45 -10.36 -0.38 2.26e-23 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs372883 0.600 rs1153277 chr21:30666867 A/T cg08807101 chr21:30365312 RNF160 -0.38 -8.13 -0.31 2.19e-15 Pancreatic cancer; BRCA cis rs10501293 0.917 rs10768914 chr11:43102263 G/A cg03447554 chr11:43094025 NA -0.44 -8.43 -0.32 2.33e-16 Cognitive performance; BRCA cis rs698833 0.780 rs2005203 chr2:44541725 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.49 10.09 0.37 2.67e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4906332 1.000 rs3783397 chr14:103947289 A/G cg26031613 chr14:104095156 KLC1 -0.44 -8.16 -0.31 1.77e-15 Coronary artery disease; BRCA cis rs13108904 0.935 rs2199956 chr4:1248919 A/G cg05665937 chr4:1216051 CTBP1 0.41 8.57 0.32 7.56e-17 Obesity-related traits; BRCA cis rs2153535 0.584 rs9502721 chr6:8541379 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.51 0.38 6.01e-24 Motion sickness; BRCA cis rs7539409 0.915 rs761404 chr1:84226766 G/T cg10977910 chr1:84465055 TTLL7 -0.61 -8.0 -0.3 5.72e-15 Alzheimer's disease; BRCA cis rs6840360 0.571 rs7674244 chr4:152488302 T/C cg22705602 chr4:152727874 NA -0.31 -8.06 -0.3 3.68e-15 Intelligence (multi-trait analysis); BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg21143896 chr7:2802374 GNA12 -0.34 -8.6 -0.32 6.03e-17 Height; BRCA cis rs10501293 0.543 rs4272772 chr11:42989183 T/C cg03447554 chr11:43094025 NA 0.42 7.96 0.3 7.83e-15 Cognitive performance; BRCA cis rs1904096 0.506 rs114312933 chr4:95216802 C/T cg11021082 chr4:95130006 SMARCAD1 -0.45 -10.45 -0.38 1.02e-23 Type 2 diabetes; BRCA cis rs13102973 0.965 rs13131455 chr4:135883112 A/C cg14419869 chr4:135874104 NA -0.51 -10.74 -0.39 7.45e-25 Subjective well-being; BRCA cis rs941873 0.868 rs2181080 chr10:81121960 A/G cg09469691 chr10:81107165 PPIF 0.51 10.61 0.39 2.45e-24 Height; BRCA cis rs9467773 0.595 rs12525810 chr6:26623511 T/A cg11502198 chr6:26597334 ABT1 0.49 9.52 0.35 3.45e-20 Intelligence (multi-trait analysis); BRCA cis rs4332037 0.510 rs11762803 chr7:1886805 A/G cg12591125 chr7:1885375 MAD1L1 0.43 8.83 0.33 1.02e-17 Bipolar disorder; BRCA cis rs2832191 0.703 rs2853827 chr21:30443596 T/C cg24692254 chr21:30365293 RNF160 0.79 22.1 0.66 7.47e-81 Dental caries; BRCA cis rs3806843 0.771 rs2563336 chr5:140107199 A/G cg26395211 chr5:140044315 WDR55 0.37 8.43 0.32 2.36e-16 Depressive symptoms (multi-trait analysis); BRCA trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg15704280 chr7:45808275 SEPT13 -0.7 -14.25 -0.49 3.26e-40 Coronary artery disease; BRCA cis rs4363385 0.818 rs946095 chr1:153006470 T/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.84 -0.3 1.86e-14 Inflammatory skin disease; BRCA cis rs9463078 0.774 rs12199720 chr6:45307443 C/T cg25276700 chr6:44698697 NA 0.36 8.2 0.31 1.32e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg13334819 chr7:99746414 C7orf59 -0.43 -9.98 -0.37 6.64e-22 Coronary artery disease; BRCA cis rs6120849 0.707 rs752075 chr20:33591591 C/A cg24642439 chr20:33292090 TP53INP2 0.58 10.12 0.37 1.91e-22 Protein C levels; BRCA cis rs1555322 0.530 rs2250205 chr20:33867924 C/T cg17927777 chr20:33865990 NA 0.42 8.04 0.3 4.36e-15 Attention deficit hyperactivity disorder; BRCA cis rs701145 0.585 rs1713828 chr3:153838553 C/T cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs7618501 0.633 rs2353579 chr3:50027774 C/T cg24308560 chr3:49941425 MST1R -0.4 -8.59 -0.32 6.72e-17 Intelligence (multi-trait analysis); BRCA cis rs881375 0.715 rs11794516 chr9:123640230 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.3 0.35 2.18e-19 Rheumatoid arthritis; BRCA cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg24558204 chr6:135376177 HBS1L 0.57 15.35 0.52 1.74e-45 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9368481 0.646 rs75843621 chr6:26967881 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.35 -12.8 -0.45 1.47e-33 Autism spectrum disorder or schizophrenia; BRCA cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.52 -0.32 1.15e-16 Aortic root size; BRCA cis rs7659604 0.517 rs56311153 chr4:122729685 T/C cg20573242 chr4:122745356 CCNA2 0.49 10.99 0.4 7.79e-26 Type 2 diabetes; BRCA cis rs2797160 1.000 rs926853 chr6:126021435 A/T cg05901451 chr6:126070800 HEY2 0.39 9.47 0.35 5.21e-20 Endometrial cancer; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg12564285 chr5:131593104 PDLIM4 0.37 10.07 0.37 3.15e-22 Breast cancer; BRCA cis rs7737355 0.947 rs10067982 chr5:130835940 C/G cg06307176 chr5:131281290 NA 0.53 10.26 0.38 5.52e-23 Life satisfaction; BRCA cis rs877282 1.000 rs877282 chr10:771532 G/A cg17470449 chr10:769945 NA 0.49 8.68 0.32 3.22e-17 Uric acid levels; BRCA cis rs9467711 0.591 rs16891315 chr6:26111756 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.49 0.35 4.65e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg24250549 chr1:154909240 PMVK -0.61 -14.61 -0.5 6.36e-42 Prostate cancer; BRCA cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg00631329 chr6:26305371 NA -0.44 -13.0 -0.46 1.8e-34 Educational attainment; BRCA cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg26384229 chr12:38710491 ALG10B 0.69 16.21 0.54 9.67e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs1008375 1.000 rs28497813 chr4:17685503 A/G cg15017067 chr4:17643749 FAM184B 0.31 9.64 0.36 1.27e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11583043 0.918 rs11581062 chr1:101407519 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.43 -9.57 -0.35 2.38e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs13082711 0.911 rs7650165 chr3:27462440 C/T cg02860705 chr3:27208620 NA 0.54 10.73 0.39 8.49e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs708547 0.874 rs1718869 chr4:57880232 A/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.5 11.94 0.43 8.09e-30 Response to bleomycin (chromatid breaks); BRCA cis rs4594175 0.926 rs116372620 chr14:51599682 T/C cg23942311 chr14:51606299 NA 0.34 8.47 0.32 1.74e-16 Cancer; BRCA cis rs67460515 0.892 rs1382429 chr3:161015153 T/C cg17135325 chr3:160939158 NMD3 0.41 7.93 0.3 9.66e-15 Parkinson's disease; BRCA trans rs11722228 1.000 rs11722228 chr4:9915741 C/T cg26043149 chr18:55253948 FECH 0.56 12.2 0.43 6.54e-31 Gout;Urate levels;Serum uric acid levels; BRCA cis rs4642101 0.824 rs9835677 chr3:12845158 G/A cg24848339 chr3:12840334 CAND2 0.41 10.56 0.39 3.86e-24 QRS complex (12-leadsum); BRCA cis rs7523050 0.643 rs12736534 chr1:109399934 T/C cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs13064411 0.735 rs9875025 chr3:113147552 T/C cg18753928 chr3:113234510 CCDC52 -0.44 -8.77 -0.33 1.64e-17 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg10932868 chr11:921992 NA 0.5 12.8 0.45 1.55e-33 Alzheimer's disease (late onset); BRCA cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg10169327 chr19:45448959 APOC2 0.31 7.81 0.3 2.28e-14 Blood protein levels; BRCA cis rs4409675 0.576 rs2815707 chr1:28238880 T/C cg23691781 chr1:28212827 C1orf38 0.32 10.63 0.39 2.04e-24 Corneal astigmatism; BRCA cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.45e-16 Bipolar disorder; BRCA cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg03146154 chr1:46216737 IPP 0.51 11.19 0.4 1.09e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1814175 0.538 rs1684260 chr11:49224231 G/A cg11707556 chr5:10655725 ANKRD33B 0.39 9.23 0.34 3.79e-19 Height; BRCA cis rs6733011 0.578 rs4851171 chr2:99510817 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.35 -8.03 -0.3 4.68e-15 Bipolar disorder; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg08470875 chr2:26401718 FAM59B -0.76 -12.08 -0.43 2.19e-30 Gut microbiome composition (summer); BRCA trans rs4650994 0.525 rs10913574 chr1:178536482 G/C cg05059571 chr16:84539110 KIAA1609 -0.54 -12.12 -0.43 1.43e-30 HDL cholesterol levels;HDL cholesterol; BRCA cis rs832540 0.864 rs252908 chr5:56120686 T/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.47 -0.32 1.73e-16 Coronary artery disease; BRCA cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg19729930 chr2:74357872 NA 0.72 15.09 0.51 3.04e-44 Gestational age at birth (maternal effect); BRCA cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg03709012 chr19:19516395 GATAD2A -0.75 -17.01 -0.56 8.07e-54 Tonsillectomy; BRCA cis rs5771242 0.518 rs6010216 chr22:50679471 C/T cg16473166 chr22:50639996 SELO 0.72 13.46 0.47 1.48e-36 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); BRCA cis rs4268898 0.636 rs9636438 chr2:24460566 C/T cg06627628 chr2:24431161 ITSN2 0.78 15.01 0.51 7.53e-44 Asthma; BRCA cis rs8180040 0.654 rs9837343 chr3:47177388 C/T cg27129171 chr3:47204927 SETD2 0.73 17.82 0.58 5.81e-58 Colorectal cancer; BRCA cis rs2797160 1.000 rs1739347 chr6:126014157 C/T cg05901451 chr6:126070800 HEY2 0.39 9.5 0.35 4.27e-20 Endometrial cancer; BRCA cis rs3125734 0.633 rs3852412 chr10:64050288 C/T cg19640130 chr10:64028056 RTKN2 -0.32 -8.91 -0.33 5.37e-18 Rheumatoid arthritis; BRCA cis rs13191362 1.000 rs34344906 chr6:162993378 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.9 14.11 0.49 1.47e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs55882075 0.967 rs59666900 chr5:179147641 C/T cg14593053 chr5:179126677 CANX 0.4 10.09 0.37 2.62e-22 Monocyte percentage of white cells; BRCA cis rs870825 0.616 rs6844588 chr4:185644517 T/G cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs12497850 0.864 rs4521268 chr3:49137904 G/T cg06212747 chr3:49208901 KLHDC8B 0.5 10.33 0.38 3.05e-23 Parkinson's disease; BRCA cis rs1267303 0.642 rs2404611 chr1:46997127 C/G cg25110126 chr1:46999211 NA 0.67 12.79 0.45 1.7e-33 Monobrow; BRCA cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg18512352 chr11:47633146 NA -0.33 -7.93 -0.3 1.01e-14 Subjective well-being; BRCA cis rs2712184 0.756 rs2712161 chr2:217662384 G/A cg05032264 chr2:217675019 NA -0.35 -8.66 -0.32 3.84e-17 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs6087990 0.835 rs4911106 chr20:31331330 A/G cg13636640 chr20:31349939 DNMT3B 0.71 21.42 0.65 4.07e-77 Ulcerative colitis; BRCA cis rs3824867 0.920 rs9919526 chr11:47451623 C/T cg20307385 chr11:47447363 PSMC3 -0.49 -10.94 -0.4 1.16e-25 Mean corpuscular hemoglobin; BRCA cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg21770322 chr7:97807741 LMTK2 0.42 11.16 0.4 1.55e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs2032447 0.670 rs198834 chr6:26114372 G/A cg03517284 chr6:25882590 NA 0.39 8.12 0.31 2.47e-15 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.61 12.87 0.45 7.21e-34 Lymphocyte counts; BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg01262667 chr19:19385393 TM6SF2 0.41 10.73 0.39 8.34e-25 Tonsillectomy; BRCA trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg15704280 chr7:45808275 SEPT13 0.69 14.18 0.49 6.74e-40 Coronary artery disease; BRCA cis rs9818758 0.607 rs35283189 chr3:49113668 T/C cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs782590 0.967 rs782592 chr2:55843875 T/A cg18811423 chr2:55921094 PNPT1 0.54 14.41 0.5 5.96e-41 Metabolic syndrome; BRCA cis rs2032447 0.714 rs199736 chr6:25936787 C/T cg03264133 chr6:25882463 NA -0.49 -10.62 -0.39 2.26e-24 Intelligence (multi-trait analysis); BRCA cis rs7927771 0.524 rs10458915 chr11:47864392 T/A cg20307385 chr11:47447363 PSMC3 0.42 9.49 0.35 4.65e-20 Subjective well-being; BRCA cis rs7809950 0.953 rs2520263 chr7:107179119 T/C cg23024343 chr7:107201750 COG5 -0.41 -9.36 -0.35 1.29e-19 Coronary artery disease; BRCA cis rs9875589 0.509 rs2731332 chr3:14110083 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.97 0.33 3.29e-18 Ovarian reserve; BRCA cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg05729581 chr11:3078854 CARS -0.36 -8.72 -0.33 2.42e-17 Longevity; BRCA cis rs7267979 0.868 rs6138546 chr20:25216534 G/A cg08601574 chr20:25228251 PYGB 0.38 9.31 0.35 2e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7267979 1.000 rs2482931 chr20:25334445 G/A cg08601574 chr20:25228251 PYGB -0.39 -9.12 -0.34 9.78e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6750047 0.719 rs1583171 chr2:38270107 G/A cg07380506 chr2:38303506 CYP1B1 0.42 9.61 0.36 1.62e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -8.99 -0.34 2.69e-18 Total body bone mineral density; BRCA cis rs17401966 1.000 rs1339458 chr1:10328338 C/T cg03954927 chr1:10346856 KIF1B 0.45 13.12 0.46 5.4e-35 Hepatocellular carcinoma; BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg26769984 chr7:1090371 C7orf50 0.48 9.1 0.34 1.16e-18 Bronchopulmonary dysplasia; BRCA cis rs1451375 0.959 rs6962356 chr7:50621941 T/C cg18232548 chr7:50535776 DDC 0.39 9.55 0.35 2.81e-20 Malaria; BRCA cis rs6088590 1.000 rs2378256 chr20:33292127 G/C cg08999081 chr20:33150536 PIGU 0.37 9.32 0.35 1.93e-19 Coronary artery disease; BRCA cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs7584330 0.868 rs67071074 chr2:238395429 T/C cg11271282 chr2:238384023 NA 0.45 8.35 0.31 4.16e-16 Prostate cancer; BRCA cis rs698833 0.926 rs1067347 chr2:44672165 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.45 -9.03 -0.34 2.08e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg26119090 chr2:26468346 HADHA;HADHB -1.07 -24.14 -0.69 5.6e-92 Gut microbiome composition (summer); BRCA cis rs7580658 0.545 rs885275 chr2:127951095 T/C cg16751203 chr2:127950803 CYP27C1 0.28 7.98 0.3 6.69e-15 Protein C levels; BRCA cis rs6570726 0.791 rs6902410 chr6:145905261 G/A cg23711669 chr6:146136114 FBXO30 0.74 17.37 0.57 1.2e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.06 -0.34 1.55e-18 Alzheimer's disease (late onset); BRCA cis rs875971 0.545 rs73146609 chr7:65767464 A/G cg11764359 chr7:65958608 NA 0.65 11.14 0.4 1.9e-26 Aortic root size; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg04025307 chr7:1156635 C7orf50 0.59 9.31 0.35 2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs6582630 0.502 rs11520261 chr12:38332019 T/G cg06521331 chr12:34319734 NA -0.48 -9.24 -0.34 3.75e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg08470875 chr2:26401718 FAM59B 0.59 7.94 0.3 9.38e-15 Gut microbiome composition (summer); BRCA cis rs1451375 0.785 rs10278338 chr7:50630270 C/T cg18232548 chr7:50535776 DDC 0.41 9.79 0.36 3.36e-21 Malaria; BRCA trans rs9325144 0.647 rs12822023 chr12:39097964 T/C cg23762105 chr12:34175262 ALG10 0.35 7.87 0.3 1.49e-14 Morning vs. evening chronotype; BRCA cis rs11105298 1.000 rs11105298 chr12:89876143 C/T cg00757033 chr12:89920650 WDR51B -0.51 -10.5 -0.38 6.95e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg21226059 chr5:178986404 RUFY1 0.36 8.35 0.31 4.27e-16 Lung cancer; BRCA cis rs9467773 0.583 rs2498380 chr6:26643996 C/G cg11502198 chr6:26597334 ABT1 -0.57 -11.97 -0.43 6.16e-30 Intelligence (multi-trait analysis); BRCA cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.54 -16.88 -0.56 4.08e-53 Total body bone mineral density; BRCA cis rs7613875 0.580 rs6808044 chr3:50136165 A/G cg14019146 chr3:50243930 SLC38A3 0.44 10.53 0.38 5.05e-24 Body mass index; BRCA trans rs9951602 0.512 rs9946120 chr18:76654548 A/T cg02800362 chr5:177631904 HNRNPAB 0.78 18.28 0.59 2.2e-60 Obesity-related traits; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg00814883 chr7:100076585 TSC22D4 -0.49 -10.26 -0.38 5.9e-23 Platelet count; BRCA cis rs6878727 0.638 rs170345 chr5:123674517 G/A cg01806427 chr5:123737813 NA -0.36 -8.15 -0.31 1.97e-15 Breast cancer; BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.42 -7.91 -0.3 1.15e-14 Gut microbiome composition (summer); BRCA cis rs698813 0.851 rs698812 chr2:44703714 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 8.89 0.33 6.18e-18 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs757110 0.770 rs1557765 chr11:17403639 T/C cg15432903 chr11:17409602 KCNJ11 0.7 15.36 0.52 1.55e-45 Type 2 diabetes; BRCA cis rs4742903 0.967 rs7048372 chr9:106859738 T/C cg21169611 chr9:106856078 SMC2 0.35 9.25 0.34 3.19e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs801193 1.000 rs4717319 chr7:66242593 A/G cg18876405 chr7:65276391 NA 0.61 15.02 0.51 6.93e-44 Aortic root size; BRCA cis rs11098499 0.954 rs6857105 chr4:120222298 C/G cg09307838 chr4:120376055 NA 0.67 13.87 0.48 2.09e-38 Corneal astigmatism; BRCA cis rs9828933 0.752 rs13434089 chr3:63948566 C/T cg16258503 chr3:63850278 ATXN7;THOC7 0.72 11.99 0.43 5.24e-30 Type 2 diabetes; BRCA trans rs2562456 0.793 rs7259708 chr19:21750648 T/C cg25042112 chr7:64838748 ZNF92 -0.45 -8.23 -0.31 1.03e-15 Pain; BRCA cis rs9393692 0.645 rs766407 chr6:26319534 T/C cg13736514 chr6:26305472 NA -0.46 -14.79 -0.5 8.88e-43 Educational attainment; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18301423 chr5:131593218 PDLIM4 -0.34 -8.7 -0.33 2.88e-17 Breast cancer; BRCA cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg23711669 chr6:146136114 FBXO30 0.72 17.44 0.57 5.49e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467773 0.620 rs1490488 chr6:26614808 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.88 0.51 3.21e-43 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs10890377 chr1:46406594 G/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 3.97e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 0.721 rs28442079 chr1:46172001 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.85 -0.3 1.74e-14 Total body bone mineral density; BRCA cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4e-25 Smoking initiation; BRCA cis rs921968 0.541 rs585185 chr2:219457741 G/A cg02176678 chr2:219576539 TTLL4 0.46 12.15 0.43 1.04e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs9858542 0.953 rs6779524 chr3:49450449 C/T cg03060546 chr3:49711283 APEH -0.51 -10.52 -0.38 5.42e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg03116740 chr11:841335 TSPAN4;POLR2L -0.36 -8.03 -0.3 4.78e-15 Mean platelet volume; BRCA cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg19628046 chr18:33552617 C18orf21 0.51 10.55 0.39 4.3e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg22920501 chr2:26401640 FAM59B 0.94 16.23 0.54 7.34e-50 Gut microbiome composition (summer); BRCA cis rs6840360 0.615 rs1962910 chr4:152479392 T/A cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs875971 0.830 rs809025 chr7:65849819 C/G cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA cis rs6137287 0.668 rs6082329 chr20:21100138 G/T cg04219410 chr20:21106687 PLK1S1 -0.34 -8.04 -0.3 4.5e-15 Height; BRCA cis rs1865760 1.000 rs6905887 chr6:25912103 T/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.13 0.4 2e-26 Height; BRCA cis rs2066819 1.000 rs2371454 chr12:56647243 A/G cg26734620 chr12:56694298 CS -0.88 -10.11 -0.37 2.09e-22 Psoriasis vulgaris; BRCA cis rs634534 0.562 rs642293 chr11:65730217 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.6 13.34 0.47 5.62e-36 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs9768139 0.708 rs921616 chr7:158117960 A/G cg24154853 chr7:158122151 PTPRN2 0.35 8.17 0.31 1.61e-15 Calcium levels; BRCA cis rs798554 0.548 rs1639064 chr7:2896544 G/A cg04166393 chr7:2884313 GNA12 0.48 10.24 0.38 6.76e-23 Height; BRCA cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg13319975 chr6:146136371 FBXO30 0.41 9.29 0.34 2.42e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg26384229 chr12:38710491 ALG10B -0.62 -15.1 -0.51 2.66e-44 Drug-induced liver injury (flucloxacillin); BRCA cis rs12971120 0.891 rs2278159 chr18:72178161 T/C cg25817165 chr18:72167213 CNDP2 -0.72 -12.7 -0.45 4.06e-33 Refractive error; BRCA cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg24130564 chr14:104152367 KLC1 -0.41 -8.77 -0.33 1.58e-17 Reticulocyte count; BRCA cis rs870825 0.929 rs72689260 chr4:185590656 G/T cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs7666738 0.830 rs35939134 chr4:98980311 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.13e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs629535 0.590 rs62513427 chr8:70138891 A/T cg21567404 chr3:27674614 NA -0.96 -17.45 -0.57 4.53e-56 Dupuytren's disease; BRCA cis rs2839186 0.721 rs13051200 chr21:47701693 A/T cg12379764 chr21:47803548 PCNT -0.37 -8.05 -0.3 4.13e-15 Testicular germ cell tumor; BRCA cis rs3741151 0.892 rs2027763 chr11:73035799 A/G cg17517138 chr11:73019481 ARHGEF17 0.57 9.0 0.34 2.5e-18 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs1215050 0.791 rs2865942 chr4:98737709 G/C cg05340658 chr4:99064831 C4orf37 0.45 10.38 0.38 1.92e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10089 0.552 rs59430737 chr5:127557568 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.49 9.45 0.35 6.04e-20 Ileal carcinoids; BRCA cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.43 0.57 5.74e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg10729496 chr3:10149963 C3orf24 0.42 8.19 0.31 1.48e-15 Alzheimer's disease; BRCA cis rs72781680 0.611 rs4149373 chr2:24300023 C/T cg20701182 chr2:24300061 SF3B14 0.71 13.46 0.47 1.49e-36 Lymphocyte counts; BRCA cis rs9486715 0.867 rs9486444 chr6:96963619 A/G cg06623918 chr6:96969491 KIAA0776 0.9 25.74 0.71 9.02e-101 Headache; BRCA cis rs7927771 0.524 rs7122182 chr11:47843133 A/C cg20307385 chr11:47447363 PSMC3 -0.41 -9.53 -0.35 3.2e-20 Subjective well-being; BRCA cis rs853679 0.517 rs4713135 chr6:28039586 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.25 -0.31 9.39e-16 Depression; BRCA cis rs7552404 0.727 rs12122939 chr1:76276353 T/C cg10523679 chr1:76189770 ACADM 0.67 12.47 0.44 4.11e-32 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs11039798 0.528 rs10769559 chr11:49032446 T/C cg03929089 chr4:120376271 NA 0.56 9.47 0.35 5.26e-20 Axial length; BRCA trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg15934090 chr1:100435551 SLC35A3 0.35 8.12 0.31 2.4e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs9443645 0.869 rs9361467 chr6:79621098 A/G cg11833968 chr6:79620685 NA -0.43 -9.55 -0.35 2.69e-20 Intelligence (multi-trait analysis); BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.1 -0.31 2.79e-15 Total body bone mineral density; BRCA cis rs27434 0.583 rs28129 chr5:96155518 G/A cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.22e-33 Ankylosing spondylitis; BRCA cis rs858239 0.508 rs10242104 chr7:23220450 C/T cg23682824 chr7:23144976 KLHL7 0.36 9.05 0.34 1.64e-18 Cerebrospinal fluid biomarker levels; BRCA trans rs637571 0.584 rs594689 chr11:65635559 G/A cg17712092 chr4:129076599 LARP1B -0.59 -13.71 -0.48 1.05e-37 Eosinophil percentage of white cells; BRCA cis rs2050392 0.624 rs303436 chr10:30731893 G/T cg18806716 chr10:30721971 MAP3K8 -0.58 -14.19 -0.49 6.54e-40 Inflammatory bowel disease; BRCA cis rs6580649 0.943 rs1859444 chr12:48399403 T/C cg24011408 chr12:48396354 COL2A1 0.54 9.25 0.34 3.23e-19 Lung cancer; BRCA cis rs3820928 0.692 rs17416354 chr2:227770844 A/G cg05526886 chr2:227700861 RHBDD1 -0.41 -8.54 -0.32 9.82e-17 Pulmonary function; BRCA cis rs61935443 0.666 rs11107781 chr12:95301086 T/A cg21533806 chr12:95267307 NA 0.47 8.18 0.31 1.57e-15 Schizophrenia; BRCA cis rs4930561 0.714 rs7950452 chr11:67962407 C/A cg16338278 chr11:67432957 ALDH3B2 0.44 8.97 0.33 3.37e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg27588902 chr6:42928151 GNMT -0.3 -10.1 -0.37 2.28e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7666738 0.830 rs7657179 chr4:98948569 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.9e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs60871478 1.000 rs12531530 chr7:827366 T/C cg05535760 chr7:792225 HEATR2 0.84 14.56 0.5 1.1e-41 Cerebrospinal P-tau181p levels; BRCA cis rs2243480 1.000 rs34933526 chr7:65383199 A/G cg18252515 chr7:66147081 NA -0.84 -12.14 -0.43 1.2e-30 Diabetic kidney disease; BRCA cis rs3768617 0.510 rs723014 chr1:183076287 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.83 0.58 4.89e-58 Fuchs's corneal dystrophy; BRCA cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg06238570 chr21:40685208 BRWD1 -0.4 -8.14 -0.31 2.02e-15 Menarche (age at onset); BRCA cis rs72781680 0.950 rs56128748 chr2:24126809 T/G cg20701182 chr2:24300061 SF3B14 0.55 8.6 0.32 6.09e-17 Lymphocyte counts; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg00149659 chr3:10157352 C3orf10 1.06 17.88 0.58 2.77e-58 Alzheimer's disease; BRCA cis rs2243480 1.000 rs316313 chr7:65593548 G/A cg18252515 chr7:66147081 NA -1.07 -15.7 -0.53 3.09e-47 Diabetic kidney disease; BRCA cis rs4908768 0.501 rs6577502 chr1:8615577 T/C cg20416874 chr1:8611966 RERE -0.29 -8.43 -0.32 2.38e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs7833986 0.534 rs17759244 chr8:57033768 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.82 0.45 1.2e-33 Height; BRCA cis rs3820928 0.869 rs2396436 chr2:227795464 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.84 -0.33 8.99e-18 Pulmonary function; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg18402987 chr7:1209562 NA 0.6 12.9 0.45 5.41e-34 Longevity;Endometriosis; BRCA cis rs9470366 1.000 rs9470366 chr6:36625562 C/T cg08179530 chr6:36648295 CDKN1A 0.46 8.93 0.33 4.59e-18 QRS duration; BRCA cis rs9858542 0.953 rs9837341 chr3:49664767 A/G cg03060546 chr3:49711283 APEH -0.58 -11.9 -0.43 1.23e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg00814883 chr7:100076585 TSC22D4 -0.54 -11.77 -0.42 4.25e-29 Platelet count; BRCA cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg00800038 chr16:89945340 TCF25 -0.7 -10.62 -0.39 2.23e-24 Skin colour saturation; BRCA cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg24399712 chr22:39784796 NA 0.59 12.77 0.45 1.98e-33 Intelligence (multi-trait analysis); BRCA cis rs11690935 0.877 rs72890834 chr2:172835802 G/T cg13550731 chr2:172543902 DYNC1I2 -0.89 -27.13 -0.73 1.94e-108 Schizophrenia; BRCA cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg22029157 chr1:209979665 IRF6 0.55 11.21 0.41 9.49e-27 Cleft lip with or without cleft palate; BRCA cis rs7772486 0.790 rs2485632 chr6:146193228 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -10.12 -0.37 2e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs4242434 0.536 rs1871900 chr8:22481449 A/G cg03733263 chr8:22462867 KIAA1967 0.69 15.6 0.53 9.83e-47 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs17376456 0.877 rs10059230 chr5:93450347 A/G cg25358565 chr5:93447407 FAM172A 1.18 19.93 0.62 4.39e-69 Diabetic retinopathy; BRCA cis rs1018836 0.812 rs10808619 chr8:91622916 A/T cg16814680 chr8:91681699 NA -0.61 -13.64 -0.47 2.41e-37 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6840360 0.593 rs28602726 chr4:152499788 T/C cg22705602 chr4:152727874 NA -0.32 -8.22 -0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs4660895 chr1:46329739 C/T cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.76e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9467773 0.566 rs66972160 chr6:26359306 T/C cg09904177 chr6:26538194 HMGN4 -0.32 -8.72 -0.33 2.41e-17 Intelligence (multi-trait analysis); BRCA trans rs7178375 1.000 rs4779797 chr15:31208425 C/T cg04373760 chr16:53404718 NA -0.47 -9.06 -0.34 1.61e-18 Hypertriglyceridemia; BRCA cis rs7267979 1.000 rs6050542 chr20:25318879 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.78 -0.36 3.81e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg21143896 chr7:2802374 GNA12 0.34 8.77 0.33 1.59e-17 Height; BRCA cis rs9291683 0.609 rs36084205 chr4:10028678 A/C cg00071950 chr4:10020882 SLC2A9 0.65 16.24 0.54 6.46e-50 Bone mineral density; BRCA trans rs3857536 0.813 rs9360190 chr6:66942302 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.12 -0.31 2.36e-15 Blood trace element (Cu levels); BRCA cis rs854572 0.600 rs705382 chr7:94955221 C/G cg01874867 chr7:94954059 PON1 -0.37 -8.14 -0.31 2.13e-15 Paraoxonase activity; BRCA cis rs2075371 0.933 rs2544181 chr7:133944934 C/T cg11752832 chr7:134001865 SLC35B4 0.49 12.1 0.43 1.76e-30 Mean platelet volume; BRCA cis rs4363385 0.720 rs1984197 chr1:152962915 C/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.69 -0.33 3.09e-17 Inflammatory skin disease; BRCA cis rs3820928 0.874 rs10176882 chr2:227896432 A/T cg11843606 chr2:227700838 RHBDD1 -0.36 -7.9 -0.3 1.19e-14 Pulmonary function; BRCA cis rs10791323 0.628 rs10750543 chr11:133718467 G/A cg14349672 chr11:133703707 NA -0.4 -9.22 -0.34 4.33e-19 Childhood ear infection; BRCA cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg05347473 chr6:146136440 FBXO30 -0.41 -7.95 -0.3 8.44e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2412459 1.000 rs6492925 chr15:40304170 T/G cg10636054 chr15:40330586 SRP14 0.53 8.62 0.32 5.25e-17 Response to haloperidol in psychosis; BRCA cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg17892150 chr10:133769511 PPP2R2D -0.72 -15.39 -0.52 1.04e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4268898 0.560 rs78711174 chr2:24496531 G/A cg06627628 chr2:24431161 ITSN2 -0.78 -14.63 -0.5 5.26e-42 Asthma; BRCA cis rs7582180 0.764 rs10180423 chr2:100919012 C/G cg14675211 chr2:100938903 LONRF2 0.46 10.71 0.39 1.04e-24 Intelligence (multi-trait analysis); BRCA cis rs965469 1.000 rs6051722 chr20:3274435 A/G cg25506879 chr20:3388711 C20orf194 -0.54 -10.42 -0.38 1.34e-23 IFN-related cytopenia; BRCA cis rs7772486 0.754 rs702318 chr6:146005873 G/T cg05347473 chr6:146136440 FBXO30 -0.44 -8.67 -0.32 3.53e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs11252926 0.583 rs2066317 chr10:520309 C/T cg03684893 chr10:554711 DIP2C -0.38 -9.15 -0.34 7.41e-19 Psychosis in Alzheimer's disease; BRCA cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg06618935 chr21:46677482 NA -0.37 -7.94 -0.3 9e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17270561 0.636 rs6923367 chr6:25745852 A/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.81e-17 Iron status biomarkers; BRCA cis rs6815814 0.950 rs67206233 chr4:38807853 T/C cg02016764 chr4:38805732 TLR1 -0.6 -9.49 -0.35 4.33e-20 Breast cancer; BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg24829409 chr8:58192753 C8orf71 -0.51 -8.34 -0.31 4.71e-16 Developmental language disorder (linguistic errors); BRCA cis rs7615952 0.673 rs9821905 chr3:125620850 A/G cg05084668 chr3:125655381 ALG1L 0.85 11.82 0.42 2.65e-29 Blood pressure (smoking interaction); BRCA cis rs35306767 0.904 rs35667562 chr10:950630 G/A cg20503657 chr10:835505 NA 1.3 21.49 0.65 1.74e-77 Eosinophil percentage of granulocytes; BRCA cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg15782153 chr7:917662 C7orf20 0.43 10.38 0.38 2.06e-23 Perceived unattractiveness to mosquitoes; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18301423 chr5:131593218 PDLIM4 0.33 8.59 0.32 6.77e-17 Breast cancer; BRCA cis rs17376456 0.877 rs10057605 chr5:93443950 T/G cg21475434 chr5:93447410 FAM172A 0.72 9.14 0.34 8.25e-19 Diabetic retinopathy; BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg26314531 chr2:26401878 FAM59B -0.62 -10.9 -0.4 1.69e-25 Gut microbiome composition (summer); BRCA cis rs877529 0.967 rs6001455 chr22:39547962 C/T cg12193277 chr22:39547181 CBX7 0.46 12.55 0.44 1.91e-32 Multiple myeloma; BRCA cis rs736801 0.808 rs2706403 chr5:131799012 A/G cg07395648 chr5:131743802 NA 0.37 8.71 0.33 2.51e-17 Breast cancer;Mosquito bite size; BRCA cis rs2404602 0.967 rs7174096 chr15:77072400 A/G cg23625390 chr15:77176239 SCAPER 0.42 10.41 0.38 1.46e-23 Blood metabolite levels; BRCA cis rs7552404 1.000 rs1498315 chr1:76159225 G/A cg03433033 chr1:76189801 ACADM 0.76 17.39 0.57 9.72e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9815354 0.638 rs17218866 chr3:42017634 T/C cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs17818399 0.620 rs1598517 chr2:46857401 C/T cg02822958 chr2:46747628 ATP6V1E2 0.42 8.29 0.31 6.5e-16 Height; BRCA trans rs35110281 0.782 rs9981291 chr21:45031458 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.36 0.38 2.43e-23 Mean corpuscular volume; BRCA cis rs8062405 1.000 rs3888190 chr16:28889486 C/A cg16576597 chr16:28551801 NUPR1 0.3 8.28 0.31 7.23e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2836974 0.931 rs2836968 chr21:40642386 A/G cg11890956 chr21:40555474 PSMG1 1.04 29.41 0.76 7.29e-121 Cognitive function; BRCA cis rs2046867 0.818 rs11928620 chr3:72863209 A/C cg25664220 chr3:72788482 NA -0.55 -11.72 -0.42 7.07e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs12618769 0.597 rs7593615 chr2:99030598 C/A cg10123293 chr2:99228465 UNC50 0.4 8.1 0.31 2.75e-15 Bipolar disorder; BRCA trans rs7647973 0.626 rs2329021 chr3:49679072 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.81 -0.3 2.3e-14 Menarche (age at onset); BRCA trans rs877282 1.000 rs11253370 chr10:773712 G/A cg22713356 chr15:30763199 NA 1.17 23.7 0.68 1.43e-89 Uric acid levels; BRCA cis rs2806561 0.929 rs627304 chr1:23537555 A/G cg19743168 chr1:23544995 NA 0.45 11.13 0.4 1.94e-26 Height; BRCA cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs4722166 0.695 rs7793125 chr7:22809160 A/G cg05472934 chr7:22766657 IL6 0.5 12.89 0.45 5.98e-34 Lung cancer; BRCA cis rs7772486 0.790 rs4435956 chr6:146232403 G/C cg05347473 chr6:146136440 FBXO30 -0.41 -8.06 -0.3 3.75e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs72772090 0.539 rs11739020 chr5:96113838 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.57 12.47 0.44 4.15e-32 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs34779708 0.966 rs12260130 chr10:35467671 C/T cg03585969 chr10:35415529 CREM 0.49 10.27 0.38 5.1e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg22920501 chr2:26401640 FAM59B -0.66 -11.49 -0.41 6.36e-28 Gut microbiome composition (summer); BRCA cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg14403583 chr14:105418241 AHNAK2 -0.38 -8.97 -0.33 3.39e-18 Rheumatoid arthritis; BRCA cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg04553112 chr3:125709451 NA -0.54 -8.12 -0.31 2.34e-15 Blood pressure (smoking interaction); BRCA cis rs11711311 1.000 rs9830975 chr3:113486019 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.77 -0.36 4.24e-21 IgG glycosylation; BRCA cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg07537917 chr2:241836409 C2orf54 -0.49 -11.59 -0.42 2.41e-28 Urinary metabolites; BRCA trans rs12458462 0.787 rs56006341 chr18:77439844 G/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -8.69 -0.33 3e-17 Monocyte count; BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg24060327 chr5:131705240 SLC22A5 -0.42 -7.9 -0.3 1.2e-14 Acylcarnitine levels; BRCA cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg07606381 chr6:8435919 SLC35B3 0.64 14.11 0.49 1.54e-39 Motion sickness; BRCA cis rs6840360 0.615 rs6858483 chr4:152465509 C/T cg25486957 chr4:152246857 NA -0.35 -7.81 -0.3 2.37e-14 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg06784218 chr1:46089804 CCDC17 0.49 11.66 0.42 1.25e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs28417577 chr4:99053007 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs6089829 0.962 rs6122344 chr20:61661738 C/T cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg20503657 chr10:835505 NA 0.92 14.47 0.5 3.1e-41 Eosinophil percentage of granulocytes; BRCA cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.55 -0.35 2.8e-20 Tonsillectomy; BRCA cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg17366294 chr4:99064904 C4orf37 0.51 11.46 0.41 8.52e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs8016982 1.000 rs12147118 chr14:81652975 A/C cg01989461 chr14:81687754 GTF2A1 -0.48 -10.1 -0.37 2.37e-22 Schizophrenia; BRCA cis rs10504229 0.610 rs6999661 chr8:58127391 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs858239 0.670 rs6967526 chr7:23159241 C/A cg23682824 chr7:23144976 KLHL7 0.41 10.35 0.38 2.67e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg24642844 chr7:1081250 C7orf50 -0.73 -13.66 -0.48 1.91e-37 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9467711 0.591 rs35528636 chr6:25995701 A/C cg08501292 chr6:25962987 TRIM38 0.59 8.02 0.3 4.97e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs61931739 0.517 rs11053063 chr12:34181011 C/T cg06521331 chr12:34319734 NA -0.63 -11.57 -0.42 2.98e-28 Morning vs. evening chronotype; BRCA cis rs7100689 0.646 rs2486302 chr10:82076600 G/A cg00277334 chr10:82204260 NA -0.43 -8.47 -0.32 1.74e-16 Post bronchodilator FEV1; BRCA cis rs7103648 0.966 rs1534576 chr11:47419663 A/C cg20307385 chr11:47447363 PSMC3 -0.86 -26.13 -0.72 5.92e-103 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2075371 1.000 rs8134 chr7:133974519 A/G cg02659138 chr7:134003124 SLC35B4 0.32 10.09 0.37 2.59e-22 Mean platelet volume; BRCA cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7131987 0.903 rs7308125 chr12:29425211 T/C cg09582351 chr12:29534625 ERGIC2 -0.49 -11.87 -0.43 1.61e-29 QT interval; BRCA cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg26248373 chr2:1572462 NA -0.49 -9.83 -0.36 2.52e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.54 16.6 0.55 9.75e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs534126 0.778 rs6464540 chr7:142954903 G/A cg15652212 chr7:142981776 TMEM139 0.46 10.44 0.38 1.12e-23 Cancer; BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg08470875 chr2:26401718 FAM59B -0.72 -12.37 -0.44 1.15e-31 Gut microbiome composition (summer); BRCA cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg16099169 chr2:106886729 NA -0.59 -10.55 -0.39 4.11e-24 Facial morphology (factor 23); BRCA cis rs10751667 0.643 rs10902244 chr11:949981 A/G cg10932868 chr11:921992 NA 0.5 12.8 0.45 1.55e-33 Alzheimer's disease (late onset); BRCA cis rs13217239 0.646 rs10946898 chr6:27003884 T/C cg12292205 chr6:26970375 C6orf41 0.57 12.66 0.45 6.35e-33 Schizophrenia; BRCA cis rs754466 0.651 rs56138814 chr10:79625795 T/C cg17075019 chr10:79541650 NA -0.73 -17.59 -0.57 8.49e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2421770 0.530 rs11033084 chr11:35367408 T/G cg13971030 chr11:35366721 SLC1A2 -0.43 -9.57 -0.35 2.38e-20 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs72627123 0.500 rs67852564 chr14:74559920 A/G cg05179529 chr14:74551516 LIN52;ALDH6A1 0.54 9.25 0.34 3.44e-19 Morning vs. evening chronotype; BRCA cis rs1568889 1.000 rs16917689 chr11:28064466 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.62 0.5 5.52e-42 Bipolar disorder; BRCA cis rs589448 0.933 rs523398 chr12:69752775 C/T cg22834771 chr12:69754056 YEATS4 -0.42 -10.46 -0.38 9.51e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs765787 0.530 rs4775835 chr15:45537553 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.55 -0.42 3.82e-28 Uric acid levels; BRCA cis rs801193 0.548 rs2659904 chr7:66178602 C/A cg12463550 chr7:65579703 CRCP 0.38 8.2 0.31 1.34e-15 Aortic root size; BRCA cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg22467129 chr15:76604101 ETFA -0.42 -9.37 -0.35 1.26e-19 Blood metabolite levels; BRCA cis rs10504229 0.593 rs4738567 chr8:57997033 A/C cg21724239 chr8:58056113 NA 0.51 8.73 0.33 2.22e-17 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg21724239 chr8:58056113 NA -0.6 -9.75 -0.36 5.04e-21 Developmental language disorder (linguistic errors); BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg18758796 chr5:131593413 PDLIM4 -0.37 -9.37 -0.35 1.24e-19 Acylcarnitine levels; BRCA cis rs7582180 0.630 rs13021801 chr2:100935129 C/A cg14675211 chr2:100938903 LONRF2 0.52 12.14 0.43 1.12e-30 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.566 rs9467672 chr6:26083904 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 11.84 0.42 2.28e-29 Height; BRCA cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg25173405 chr17:45401733 C17orf57 -0.56 -12.25 -0.44 3.76e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg16339924 chr4:17578868 LAP3 0.63 15.75 0.53 1.72e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1538970 1.000 rs4660852 chr1:45848931 A/C cg05343316 chr1:45956843 TESK2 -0.58 -11.89 -0.43 1.4e-29 Platelet count; BRCA cis rs10751667 0.643 rs10902234 chr11:935578 A/G ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs769267 0.931 rs15622 chr19:19468734 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.77 -0.36 4.14e-21 Tonsillectomy; BRCA cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg04553112 chr3:125709451 NA -0.55 -8.34 -0.31 4.41e-16 Blood pressure (smoking interaction); BRCA cis rs10927875 0.541 rs1763596 chr1:16343835 C/T cg22431228 chr1:16359049 CLCNKA -0.43 -9.64 -0.36 1.27e-20 Dilated cardiomyopathy; BRCA cis rs11764590 0.694 rs4721359 chr7:2104951 A/G cg23422044 chr7:1970798 MAD1L1 -0.43 -9.3 -0.35 2.21e-19 Neuroticism; BRCA trans rs3733585 0.805 rs882222 chr4:9981294 G/A cg26043149 chr18:55253948 FECH 0.39 8.78 0.33 1.46e-17 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs634534 0.622 rs552130 chr11:65732800 T/C cg17712092 chr4:129076599 LARP1B 0.49 11.95 0.43 7.36e-30 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg24642439 chr20:33292090 TP53INP2 0.52 11.43 0.41 1.14e-27 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs9486715 0.867 rs926277 chr6:96868837 T/A cg06623918 chr6:96969491 KIAA0776 0.9 25.43 0.71 4.24e-99 Headache; BRCA cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.43 -9.52 -0.35 3.42e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs9325144 0.647 rs11169222 chr12:39105210 C/T cg26384229 chr12:38710491 ALG10B -0.48 -11.23 -0.41 7.66e-27 Morning vs. evening chronotype; BRCA cis rs8177253 0.633 rs10935073 chr3:133439184 T/C cg01448562 chr3:133502909 NA -0.44 -9.85 -0.36 2.02e-21 Iron status biomarkers; BRCA cis rs2997447 0.655 rs1317709 chr1:26384690 A/C cg19633962 chr1:26362018 EXTL1 -0.51 -9.6 -0.35 1.84e-20 QRS complex (12-leadsum); BRCA cis rs34779708 0.931 rs12767414 chr10:35390193 C/T cg03585969 chr10:35415529 CREM 0.45 9.53 0.35 3.33e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg04450456 chr4:17643702 FAM184B -0.35 -9.62 -0.36 1.5e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12348691 0.503 rs7848950 chr9:100612774 T/C cg13688889 chr9:100608707 NA -0.49 -9.91 -0.36 1.27e-21 Alopecia areata; BRCA cis rs35306767 0.761 rs12770910 chr10:1050318 A/G cg18964960 chr10:1102726 WDR37 0.63 8.71 0.33 2.65e-17 Eosinophil percentage of granulocytes; BRCA cis rs600550 0.528 rs7108307 chr11:59844861 G/T cg02771260 chr11:59836817 MS4A3 0.54 11.86 0.42 1.91e-29 Lipoprotein-associated phospholipase A2 activity and mass; BRCA cis rs6484504 0.625 rs672396 chr11:31386165 A/G cg14844989 chr11:31128820 NA 0.44 9.65 0.36 1.14e-20 Red blood cell count; BRCA cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg11301795 chr4:187892539 NA 0.32 10.5 0.38 6.74e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs8072100 0.840 rs4968319 chr17:45464967 A/G cg25173405 chr17:45401733 C17orf57 -0.57 -12.4 -0.44 8.44e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg08470875 chr2:26401718 FAM59B 0.76 11.99 0.43 4.93e-30 Gut microbiome composition (summer); BRCA cis rs1784581 0.802 rs9365359 chr6:162423945 C/A cg17173639 chr6:162384350 PARK2 0.38 9.09 0.34 1.18e-18 Itch intensity from mosquito bite; BRCA cis rs6456156 0.524 rs6932740 chr6:167466439 G/A cg07741184 chr6:167504864 NA 0.33 9.82 0.36 2.83e-21 Primary biliary cholangitis; BRCA cis rs6456156 0.792 rs4710181 chr6:167513998 T/C cg07741184 chr6:167504864 NA 0.32 9.21 0.34 4.6e-19 Primary biliary cholangitis; BRCA cis rs7647973 0.516 rs12490393 chr3:49196132 C/T cg07636037 chr3:49044803 WDR6 0.82 22.19 0.66 2.51e-81 Menarche (age at onset); BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -18.54 -0.59 9.69e-62 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs875971 0.862 rs2909688 chr7:65841612 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg08085267 chr17:45401833 C17orf57 -0.69 -15.3 -0.52 2.9e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg15017067 chr4:17643749 FAM184B 0.29 8.38 0.31 3.27e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg22974920 chr21:40686053 BRWD1 0.4 9.1 0.34 1.11e-18 Cognitive function; BRCA cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.83e-24 Motion sickness; BRCA cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg06494592 chr3:125709126 NA -0.51 -8.69 -0.32 3.12e-17 Blood pressure (smoking interaction); BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg11814155 chr7:99998594 ZCWPW1 0.47 8.36 0.31 3.8e-16 Platelet count; BRCA trans rs2204008 0.837 rs11611861 chr12:38357459 A/G cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 9.43e-17 Bladder cancer; BRCA cis rs7618501 0.633 rs2624843 chr3:49997963 G/A cg05623727 chr3:50126028 RBM5 0.42 10.1 0.37 2.46e-22 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.931 rs72789690 chr10:35382817 T/C cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6545883 0.929 rs3821222 chr2:61713526 C/G cg15711740 chr2:61764176 XPO1 -0.54 -13.74 -0.48 7.77e-38 Tuberculosis; BRCA cis rs4800452 0.826 rs4800149 chr18:20744254 A/C cg26136497 chr18:20735537 CABLES1 0.41 9.91 0.36 1.28e-21 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.77e-24 Motion sickness; BRCA cis rs6910061 1.000 rs9468446 chr6:11118718 C/T cg27233058 chr6:11094804 LOC221710 0.52 9.32 0.35 1.8e-19 Diabetic kidney disease; BRCA cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg23711669 chr6:146136114 FBXO30 -0.74 -15.52 -0.52 2.51e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs7312933 0.703 rs10880264 chr12:42586535 A/G cg01256987 chr12:42539512 GXYLT1 -0.45 -9.1 -0.34 1.1e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12541635 0.934 rs4734893 chr8:106990275 T/G cg10147462 chr8:107024639 NA 0.38 10.14 0.37 1.66e-22 Age of smoking initiation; BRCA cis rs936229 0.871 rs2290574 chr15:75135447 T/C cg14664628 chr15:75095509 CSK -0.9 -24.52 -0.7 4.55e-94 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs10754283 0.934 rs10754284 chr1:90113702 A/C cg21401794 chr1:90099060 LRRC8C 0.46 11.06 0.4 4.04e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9790314 0.747 rs1841526 chr3:160834682 A/G cg03342759 chr3:160939853 NMD3 -0.53 -10.33 -0.38 2.95e-23 Morning vs. evening chronotype; BRCA cis rs7904368 0.806 rs4612698 chr10:16855070 C/A cg14835575 chr10:16859367 RSU1 0.66 14.49 0.5 2.46e-41 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7605378 1.000 rs769958 chr2:200695901 G/A cg23649088 chr2:200775458 C2orf69 0.51 10.12 0.37 2.07e-22 Osteoporosis; BRCA cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg15557168 chr22:42548783 NA 0.3 8.38 0.31 3.24e-16 Cognitive function; BRCA cis rs7552404 0.924 rs1303169 chr1:76195041 T/C cg03433033 chr1:76189801 ACADM 0.73 18.72 0.6 1.19e-62 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.99 0.3 6.41e-15 Depression; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.58 9.23 0.34 3.94e-19 Renal function-related traits (BUN); BRCA cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg11262906 chr1:85462892 MCOLN2 0.48 9.36 0.35 1.3e-19 Serum sulfate level; BRCA cis rs870825 0.616 rs4519838 chr4:185628457 A/G cg04058563 chr4:185651563 MLF1IP 0.77 16.98 0.56 1.17e-53 Blood protein levels; BRCA cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg04450456 chr4:17643702 FAM184B 0.38 10.21 0.37 9.28e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs61931739 0.534 rs7310499 chr12:34212112 G/A cg06521331 chr12:34319734 NA -0.65 -11.92 -0.43 1.01e-29 Morning vs. evening chronotype; BRCA cis rs2153535 0.541 rs1414353 chr6:8485642 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.5 0.5 2.03e-41 Motion sickness; BRCA trans rs4714291 0.963 rs4714292 chr6:40003679 A/C cg02267698 chr19:7991119 CTXN1 0.41 8.09 0.3 2.98e-15 Strep throat; BRCA cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg11366901 chr6:160182831 ACAT2 0.76 14.89 0.51 2.96e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs7809950 1.000 rs7786801 chr7:107085889 C/T cg23024343 chr7:107201750 COG5 -0.4 -9.25 -0.34 3.2e-19 Coronary artery disease; BRCA trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg15704280 chr7:45808275 SEPT13 0.83 20.17 0.62 2.09e-70 Coronary artery disease; BRCA cis rs12711979 0.765 rs7559345 chr2:3818523 G/A cg17052675 chr2:3827356 NA -0.48 -14.1 -0.49 1.76e-39 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs7809950 1.000 rs3801954 chr7:107117048 C/T cg23024343 chr7:107201750 COG5 -0.42 -9.9 -0.36 1.39e-21 Coronary artery disease; BRCA trans rs61931739 0.534 rs1843733 chr12:34047626 T/C cg26384229 chr12:38710491 ALG10B 0.51 11.26 0.41 5.83e-27 Morning vs. evening chronotype; BRCA cis rs2050392 0.624 rs2489842 chr10:30721991 T/C cg18806716 chr10:30721971 MAP3K8 -0.61 -14.25 -0.49 3.12e-40 Inflammatory bowel disease; BRCA cis rs7666738 0.753 rs17483788 chr4:98985623 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg15017067 chr4:17643749 FAM184B 0.28 8.46 0.32 1.88e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10540 1.000 rs35898083 chr11:484469 C/T cg03352830 chr11:487213 PTDSS2 0.85 12.68 0.45 5.03e-33 Body mass index; BRCA cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg13319975 chr6:146136371 FBXO30 0.62 14.55 0.5 1.28e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg20503657 chr10:835505 NA 1.05 18.16 0.58 9.5e-60 Eosinophil percentage of granulocytes; BRCA trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg26384229 chr12:38710491 ALG10B 0.74 16.31 0.54 2.94e-50 Morning vs. evening chronotype; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg16812893 chr21:31813075 KRTAP15-1 0.39 9.86 0.36 1.86e-21 HDL cholesterol; BRCA cis rs1059312 0.966 rs35907548 chr12:129282180 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.14 0.34 8.5e-19 Systemic lupus erythematosus; BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg22535103 chr8:58192502 C8orf71 -0.49 -8.67 -0.32 3.61e-17 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs7249921 0.802 rs35746990 chr19:35666857 C/T cg15419183 chr19:35660584 FXYD5 0.46 10.59 0.39 2.95e-24 Platelet count; BRCA cis rs2011503 1.000 rs7256028 chr19:19628240 C/T cg11584989 chr19:19387371 SF4 0.5 11.21 0.41 9.48e-27 Bipolar disorder; BRCA cis rs344364 0.636 rs344363 chr16:1972548 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.69 -11.14 -0.4 1.8e-26 Glomerular filtration rate in chronic kidney disease; BRCA cis rs77861329 0.748 rs9851576 chr3:52091254 C/T cg08692210 chr3:52188851 WDR51A -0.45 -8.77 -0.33 1.67e-17 Macrophage inflammatory protein 1b levels; BRCA cis rs2904967 0.929 rs592050 chr11:65030189 C/G cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs12477438 0.765 rs1054042 chr2:99614396 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.92 -0.46 4.11e-34 Chronic sinus infection; BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs35306767 0.903 rs35370435 chr10:898205 T/C cg20503657 chr10:835505 NA 1.3 21.76 0.65 5.72e-79 Eosinophil percentage of granulocytes; BRCA cis rs17270561 0.609 rs1165181 chr6:25825390 T/A cg16482183 chr6:26056742 HIST1H1C 0.42 9.06 0.34 1.54e-18 Iron status biomarkers; BRCA cis rs6964587 0.967 rs7783414 chr7:91785957 C/T cg17063962 chr7:91808500 NA 0.61 14.52 0.5 1.72e-41 Breast cancer; BRCA cis rs9811920 0.809 rs35422475 chr3:99711545 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.57 -13.93 -0.48 1.1e-38 Axial length; BRCA cis rs9296092 0.521 rs9461886 chr6:33526770 T/C cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg06784218 chr1:46089804 CCDC17 -0.52 -12.68 -0.45 4.88e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.71e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs36051895 0.664 rs12344629 chr9:5109208 C/T cg02405213 chr9:5042618 JAK2 -0.48 -8.55 -0.32 8.8e-17 Pediatric autoimmune diseases; BRCA cis rs9467711 0.591 rs68149500 chr6:26111271 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.6 9.12 0.34 9.76e-19 Autism spectrum disorder or schizophrenia; BRCA trans rs11976180 1.000 rs4726669 chr7:143758191 C/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.43 -8.03 -0.3 4.82e-15 Obesity-related traits; BRCA trans rs11098499 0.955 rs1397608 chr4:120161744 A/G cg25214090 chr10:38739885 LOC399744 0.48 10.66 0.39 1.53e-24 Corneal astigmatism; BRCA cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.59 12.83 0.45 1.09e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs921968 0.565 rs6436070 chr2:219597960 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.07 -0.4 3.46e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9467711 0.591 rs72834617 chr6:25999175 G/A cg08501292 chr6:25962987 TRIM38 0.59 8.02 0.3 4.97e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs698813 0.763 rs786615 chr2:44590608 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.59 11.26 0.41 5.7e-27 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs17818399 0.926 rs13032670 chr2:46830794 C/T cg02822958 chr2:46747628 ATP6V1E2 0.55 10.01 0.37 5.37e-22 Height; BRCA cis rs2806561 0.704 rs856510 chr1:23524407 A/C cg19743168 chr1:23544995 NA 0.35 8.15 0.31 1.89e-15 Height; BRCA trans rs8073060 0.586 rs225256 chr17:33955756 C/T cg19694781 chr19:47549865 TMEM160 -1.06 -21.33 -0.64 1.25e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs2739330 0.828 rs5760107 chr22:24252597 T/C cg06437703 chr8:37914619 EIF4EBP1 -0.33 -8.79 -0.33 1.33e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4713118 0.868 rs742047 chr6:27739380 A/G cg20933634 chr6:27740509 NA 0.47 8.87 0.33 7.41e-18 Parkinson's disease; BRCA cis rs703842 0.892 rs1021469 chr12:58208164 C/T cg00677455 chr12:58241039 CTDSP2 0.58 13.73 0.48 8.85e-38 Multiple sclerosis; BRCA cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg22467129 chr15:76604101 ETFA -0.4 -8.91 -0.33 5.48e-18 Blood metabolite levels; BRCA cis rs2549003 1.000 rs6873426 chr5:131818631 G/T cg02551604 chr5:131831745 NA -0.39 -14.68 -0.5 2.84e-42 Asthma (sex interaction); BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg00106254 chr7:1943704 MAD1L1 -0.32 -8.17 -0.31 1.68e-15 Schizophrenia; BRCA cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg11833968 chr6:79620685 NA -0.45 -10.3 -0.38 4.07e-23 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg08888203 chr3:10149979 C3orf24 0.63 11.82 0.42 2.73e-29 Alzheimer's disease; BRCA cis rs7592578 0.882 rs61117285 chr2:191468986 G/C cg11845111 chr2:191398756 TMEM194B -0.76 -13.92 -0.48 1.2e-38 Diastolic blood pressure; BRCA cis rs9942416 0.660 rs17563686 chr5:74984818 A/T cg19683494 chr5:74908142 NA 0.48 9.0 0.34 2.64e-18 Age-related disease endophenotypes; BRCA cis rs7551345 0.653 rs7546080 chr1:31696977 G/A cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA trans rs7647973 0.626 rs1352889 chr3:49652148 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.24 -0.31 9.44e-16 Menarche (age at onset); BRCA cis rs80033912 0.640 rs6785832 chr3:49224316 C/T cg07636037 chr3:49044803 WDR6 0.49 9.64 0.36 1.31e-20 Intelligence (multi-trait analysis); BRCA cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg23796481 chr11:64053134 BAD;GPR137 0.5 10.49 0.38 7.65e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA trans rs7618501 1.000 rs9859153 chr3:49807085 G/T cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.22 0.54 8.48e-50 Intelligence (multi-trait analysis); BRCA cis rs11958404 0.932 rs111802867 chr5:157424971 G/A cg05962755 chr5:157440814 NA 0.58 10.55 0.39 4.36e-24 IgG glycosylation; BRCA cis rs4689388 0.926 rs11725500 chr4:6293919 C/G cg00701064 chr4:6280414 WFS1 0.68 17.58 0.57 9.78e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10779751 1.000 rs2253213 chr1:11265785 A/G cg08854313 chr1:11322531 MTOR 0.78 15.8 0.53 1.07e-47 Body mass index; BRCA cis rs1198430 1.000 rs1198430 chr1:23755513 C/T cg19827787 chr1:23763612 ASAP3 -0.33 -8.8 -0.33 1.29e-17 Total cholesterol levels; BRCA cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.3 0.38 3.95e-23 Bladder cancer; BRCA cis rs2274273 1.000 rs1009977 chr14:55603002 T/G cg04306507 chr14:55594613 LGALS3 0.32 8.96 0.33 3.65e-18 Protein biomarker; BRCA cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA trans rs61931739 0.500 rs34061369 chr12:34519283 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs1005277 0.579 rs2474586 chr10:38418882 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.13 -0.4 1.98e-26 Extrinsic epigenetic age acceleration; BRCA cis rs7552404 0.696 rs10518521 chr1:76461214 G/A cg22875332 chr1:76189707 ACADM 0.61 10.5 0.38 6.95e-24 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs477895 1.000 rs7939107 chr11:64034773 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 9.19 0.34 5.41e-19 Mean platelet volume; BRCA cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.45 0.38 1.07e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs965469 0.779 rs6051772 chr20:3328654 C/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg08213375 chr14:104286397 PPP1R13B 0.62 17.8 0.58 7.48e-58 Schizophrenia; BRCA cis rs7552404 1.000 rs1498316 chr1:76159198 G/A cg03433033 chr1:76189801 ACADM 0.75 16.94 0.56 1.86e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg25036284 chr2:26402008 FAM59B -0.64 -10.64 -0.39 1.96e-24 Gut microbiome composition (summer); BRCA trans rs61931739 0.500 rs7489132 chr12:34539712 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.72 -0.33 2.45e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs2882667 0.690 rs700624 chr5:138099021 C/G cg04439458 chr5:138467593 SIL1 0.31 7.85 0.3 1.74e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4308124 0.708 rs7585313 chr2:111975203 A/G cg04571233 chr2:111982156 NA -0.45 -9.65 -0.36 1.16e-20 Vitiligo; BRCA cis rs9649213 0.593 rs6963210 chr7:97944986 G/A cg24562669 chr7:97807699 LMTK2 0.44 11.77 0.42 4.24e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7520050 0.902 rs1355642 chr1:46598903 A/G cg24296786 chr1:45957014 TESK2 0.39 8.52 0.32 1.14e-16 Red blood cell count;Reticulocyte count; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg26314531 chr2:26401878 FAM59B -0.79 -12.64 -0.45 7.76e-33 Gut microbiome composition (summer); BRCA cis rs17604090 0.878 rs4457221 chr7:29701774 C/T cg19413766 chr7:29689036 LOC646762 -0.61 -8.23 -0.31 1.07e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs10189230 0.935 rs3755029 chr2:222345820 T/C cg14652038 chr2:222343519 EPHA4 0.49 13.22 0.46 1.92e-35 Urate levels in lean individuals; BRCA cis rs1552244 0.816 rs56271597 chr3:10042790 C/T cg08888203 chr3:10149979 C3orf24 0.58 11.86 0.42 1.8e-29 Alzheimer's disease; BRCA cis rs9560113 1.000 rs9555812 chr13:112181535 A/G cg10483660 chr13:112241077 NA 0.32 7.97 0.3 7.17e-15 Menarche (age at onset); BRCA cis rs7666738 0.830 rs11725652 chr4:98878362 G/A cg17366294 chr4:99064904 C4orf37 0.43 9.95 0.37 9.17e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.44 -8.47 -0.32 1.68e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9790314 1.000 rs336583 chr3:161081981 A/T cg04691961 chr3:161091175 C3orf57 0.6 14.75 0.5 1.31e-42 Morning vs. evening chronotype; BRCA trans rs7824557 0.767 rs2164273 chr8:11168499 A/G cg15556689 chr8:8085844 FLJ10661 0.37 9.06 0.34 1.56e-18 Retinal vascular caliber; BRCA cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg10862848 chr6:42927986 GNMT 0.24 8.94 0.33 4.06e-18 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); BRCA cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg04166393 chr7:2884313 GNA12 0.38 8.09 0.3 3.03e-15 Height; BRCA cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg26769984 chr7:1090371 C7orf50 0.48 9.68 0.36 8.91e-21 Bronchopulmonary dysplasia; BRCA cis rs11105298 0.891 rs3741899 chr12:89933931 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.66 -0.36 1.04e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs738322 0.967 rs132985 chr22:38563471 C/T cg25457927 chr22:38595422 NA -0.32 -11.64 -0.42 1.54e-28 Cutaneous nevi; BRCA cis rs12477438 0.520 rs13004491 chr2:99738008 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs921968 0.643 rs524012 chr2:219433273 T/G cg02176678 chr2:219576539 TTLL4 0.4 10.88 0.4 2.13e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs12310956 0.532 rs1906134 chr12:33957135 A/C cg06521331 chr12:34319734 NA -0.61 -11.11 -0.4 2.37e-26 Morning vs. evening chronotype; BRCA cis rs3767633 0.925 rs2499856 chr1:161926637 C/T cg09175582 chr1:161736000 ATF6 -0.49 -8.56 -0.32 8.19e-17 IgG glycosylation; BRCA cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg06238570 chr21:40685208 BRWD1 -0.39 -8.03 -0.3 4.7e-15 Menarche (age at onset); BRCA cis rs6543140 0.964 rs10200081 chr2:103091556 T/C cg04239558 chr2:103089729 SLC9A4 0.36 9.97 0.37 7.38e-22 Blood protein levels; BRCA cis rs8180040 0.966 rs7651762 chr3:47470484 G/A cg27129171 chr3:47204927 SETD2 -0.68 -16.02 -0.54 8.5e-49 Colorectal cancer; BRCA cis rs9487051 0.768 rs427960 chr6:109524939 C/T cg21918786 chr6:109611834 NA -0.35 -8.93 -0.33 4.33e-18 Reticulocyte fraction of red cells; BRCA trans rs1005277 0.579 rs2505241 chr10:38442421 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.0 -0.48 4.88e-39 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg26314531 chr2:26401878 FAM59B 0.68 11.42 0.41 1.26e-27 Gut microbiome composition (summer); BRCA cis rs12142240 0.698 rs1053628 chr1:46827769 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.66e-15 Menopause (age at onset); BRCA cis rs3733585 0.605 rs56178126 chr4:10123581 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -9.98 -0.37 6.6e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs4332037 0.624 rs11766944 chr7:1888051 G/A cg11693508 chr17:37793320 STARD3 0.6 11.18 0.4 1.21e-26 Bipolar disorder; BRCA trans rs7178375 1.000 rs12907055 chr15:31204294 C/G cg04373760 chr16:53404718 NA 0.47 8.81 0.33 1.2e-17 Hypertriglyceridemia; BRCA cis rs4664304 0.620 rs2048437 chr2:160712065 C/T cg14819504 chr2:160761413 LY75 0.34 8.5 0.32 1.38e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6912958 0.781 rs9450712 chr6:88193175 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.13e-16 Monocyte percentage of white cells; BRCA cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.88 -0.3 1.39e-14 Colorectal cancer; BRCA cis rs7772486 0.902 rs2777480 chr6:146309983 T/A cg23711669 chr6:146136114 FBXO30 0.64 14.53 0.5 1.48e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs7903847 0.642 rs11189177 chr10:99141663 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6860806 0.507 rs272891 chr5:131664394 G/T cg12564285 chr5:131593104 PDLIM4 0.35 8.0 0.3 6.03e-15 Breast cancer; BRCA cis rs3768617 0.510 rs12078729 chr1:183060072 T/A ch.1.3577855R chr1:183094577 LAMC1 0.68 17.95 0.58 1.27e-58 Fuchs's corneal dystrophy; BRCA cis rs27434 0.660 rs26493 chr5:96155318 C/T cg16492584 chr5:96139282 ERAP1 -0.42 -8.3 -0.31 6.27e-16 Ankylosing spondylitis; BRCA cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg02466173 chr16:30829666 NA -0.51 -11.16 -0.4 1.53e-26 Multiple myeloma; BRCA cis rs2625529 0.627 rs1037680 chr15:72514319 T/C cg16672083 chr15:72433130 SENP8 -0.81 -17.23 -0.56 6.67e-55 Red blood cell count; BRCA cis rs782590 0.967 rs4290693 chr2:55799991 C/G cg18811423 chr2:55921094 PNPT1 0.7 22.52 0.67 3.82e-83 Metabolic syndrome; BRCA cis rs12701220 0.894 rs12701348 chr7:1039457 C/T cg06145435 chr7:1022769 CYP2W1 0.47 8.93 0.33 4.57e-18 Bronchopulmonary dysplasia; BRCA trans rs2832077 0.943 rs11701445 chr21:30160807 C/T cg14791747 chr16:20752902 THUMPD1 0.4 9.79 0.36 3.61e-21 Cognitive test performance; BRCA cis rs7914558 0.752 rs7896519 chr10:104866863 C/T cg04362960 chr10:104952993 NT5C2 0.43 10.09 0.37 2.49e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs10193935 0.901 rs10170082 chr2:42623452 T/C cg27598129 chr2:42591480 NA -0.8 -13.51 -0.47 9.41e-37 Colonoscopy-negative controls vs population controls; BRCA cis rs68170813 0.559 rs79564258 chr7:107059803 C/A cg02696742 chr7:106810147 HBP1 -0.5 -8.07 -0.3 3.5e-15 Coronary artery disease; BRCA cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg20503657 chr10:835505 NA -0.45 -8.66 -0.32 3.87e-17 Response to angiotensin II receptor blocker therapy; BRCA cis rs7258465 1.000 rs2278238 chr19:18576484 T/C cg01065977 chr19:18549689 ISYNA1 -0.29 -8.5 -0.32 1.32e-16 Breast cancer; BRCA cis rs7615952 0.576 rs1127717 chr3:125826059 T/C cg06494592 chr3:125709126 NA -0.53 -8.64 -0.32 4.66e-17 Blood pressure (smoking interaction); BRCA cis rs739401 0.611 rs494427 chr11:3048140 A/G cg25174290 chr11:3078921 CARS 0.44 13.11 0.46 6.26e-35 Longevity; BRCA cis rs12618769 0.597 rs17032870 chr2:99132786 C/T cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg12463550 chr7:65579703 CRCP -0.37 -7.84 -0.3 1.88e-14 Aortic root size; BRCA cis rs35306767 0.903 rs11815185 chr10:923617 T/A cg25019033 chr10:957182 NA -0.41 -7.9 -0.3 1.24e-14 Eosinophil percentage of granulocytes; BRCA cis rs798554 0.655 rs798492 chr7:2799184 C/T cg13628971 chr7:2884303 GNA12 -0.39 -8.99 -0.34 2.69e-18 Height; BRCA cis rs62380364 0.602 rs589544 chr5:88064462 T/C cg22951263 chr5:87985283 NA -0.38 -10.39 -0.38 1.87e-23 Intelligence (multi-trait analysis); BRCA cis rs561341 1.000 rs508192 chr17:30315147 C/T cg00745463 chr17:30367425 LRRC37B 0.49 8.37 0.31 3.54e-16 Hip circumference adjusted for BMI; BRCA trans rs75804782 0.641 rs56134361 chr2:239318905 A/G cg01134436 chr17:81009848 B3GNTL1 0.77 9.69 0.36 8.3e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs55665837 1.000 rs11023214 chr11:14436259 G/C cg19336497 chr11:14380999 RRAS2 -0.36 -9.49 -0.35 4.37e-20 Vitamin D levels; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg16431978 chr21:31797932 KRTAP13-3 0.39 9.71 0.36 6.88e-21 HDL cholesterol; BRCA cis rs2663905 0.664 rs2460855 chr15:81361729 G/T cg09888468 chr15:81410853 NA -0.42 -8.87 -0.33 7.34e-18 QT interval (drug interaction); BRCA cis rs586533 0.813 rs1790263 chr11:99495583 T/G cg22878054 chr11:99397252 CNTN5 0.31 7.86 0.3 1.65e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2464469 0.654 rs2067062 chr15:58341954 T/G cg12031962 chr15:58353849 ALDH1A2 -0.32 -7.93 -0.3 1e-14 Barrett's esophagus or Esophageal adenocarcinoma; BRCA cis rs2120019 0.938 rs59094290 chr15:75308561 G/T cg17294928 chr15:75287854 SCAMP5 -0.75 -16.42 -0.54 7.94e-51 Blood trace element (Zn levels); BRCA trans rs7819412 0.505 rs17782536 chr8:11021682 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -8.35 -0.31 4.36e-16 Triglycerides; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg04944784 chr2:26401820 FAM59B 0.99 14.55 0.5 1.22e-41 Gut microbiome composition (summer); BRCA cis rs4319547 0.695 rs10773103 chr12:122856532 A/G cg05707623 chr12:122985044 ZCCHC8 0.49 9.42 0.35 7.86e-20 Body mass index; BRCA cis rs9291683 0.546 rs10939672 chr4:10052136 A/G cg02734326 chr4:10020555 SLC2A9 0.35 7.81 0.3 2.41e-14 Bone mineral density; BRCA cis rs12142240 0.698 rs56130131 chr1:46861306 A/C cg00530320 chr1:46809349 NSUN4 0.48 9.7 0.36 7.66e-21 Menopause (age at onset); BRCA cis rs7647973 0.626 rs9829155 chr3:49817450 T/C cg03060546 chr3:49711283 APEH -0.59 -10.21 -0.37 9.07e-23 Menarche (age at onset); BRCA cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg11584989 chr19:19387371 SF4 0.64 13.59 0.47 3.98e-37 Bipolar disorder; BRCA cis rs897080 0.515 rs1067368 chr2:44654889 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.28 0.34 2.67e-19 Height; BRCA cis rs1153858 1.000 rs66528868 chr15:45668547 A/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.62 0.42 1.93e-28 Homoarginine levels; BRCA cis rs4363385 0.747 rs1415962 chr1:152958731 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.41 -0.32 2.62e-16 Inflammatory skin disease; BRCA cis rs887829 0.570 rs6724485 chr2:234592816 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.32 -8.31 -0.31 5.65e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs1005277 0.579 rs2504143 chr10:38383706 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -16.95 -0.56 1.63e-53 Extrinsic epigenetic age acceleration; BRCA cis rs2243480 1.000 rs313824 chr7:65581207 C/T cg18252515 chr7:66147081 NA -1.05 -15.27 -0.52 4.18e-45 Diabetic kidney disease; BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg24633833 chr3:10029261 TMEM111 0.41 7.81 0.3 2.39e-14 Alzheimer's disease; BRCA cis rs6121246 0.909 rs6088962 chr20:30268184 C/T cg13852791 chr20:30311386 BCL2L1 0.76 12.37 0.44 1.18e-31 Mean corpuscular hemoglobin; BRCA cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg20701182 chr2:24300061 SF3B14 0.68 12.76 0.45 2.28e-33 Lymphocyte counts; BRCA cis rs4481887 0.861 rs6669290 chr1:248476804 G/A cg13385794 chr1:248469461 NA 0.27 7.87 0.3 1.5e-14 Common traits (Other); BRCA cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.34 0.49 1.26e-40 Personality dimensions; BRCA cis rs7917772 0.636 rs2863718 chr10:104519631 G/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.44 -0.38 1.17e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10771431 0.967 rs7137443 chr12:9372029 C/T cg22349387 chr12:9600060 DDX12 -0.39 -9.04 -0.34 1.86e-18 Breast size; BRCA cis rs4891159 0.790 rs4891161 chr18:74142683 A/G cg24786174 chr18:74118243 ZNF516 -0.79 -21.73 -0.65 7.8e-79 Longevity; BRCA cis rs6684514 1.000 rs10908498 chr1:156278175 T/C cg16558208 chr1:156270281 VHLL 0.34 8.07 0.3 3.48e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg00071950 chr4:10020882 SLC2A9 0.51 12.6 0.45 1.12e-32 Bone mineral density; BRCA cis rs13046373 0.535 rs7276743 chr21:31984545 C/T cg16431978 chr21:31797932 KRTAP13-3 0.35 8.58 0.32 7.07e-17 HDL cholesterol; BRCA cis rs703842 0.963 rs923829 chr12:58174306 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.54 11.14 0.4 1.91e-26 Multiple sclerosis; BRCA cis rs561341 1.000 rs550264 chr17:30317540 G/T cg00745463 chr17:30367425 LRRC37B -0.54 -8.89 -0.33 6.17e-18 Hip circumference adjusted for BMI; BRCA cis rs614226 0.872 rs787827 chr12:120937794 A/G cg27489772 chr12:121021490 NA 0.44 7.95 0.3 8.41e-15 Type 1 diabetes nephropathy; BRCA cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg12310025 chr6:25882481 NA -0.43 -9.73 -0.36 5.93e-21 Intelligence (multi-trait analysis); BRCA cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.77 0.39 5.56e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7809950 0.723 rs2237662 chr7:106874065 C/G cg23024343 chr7:107201750 COG5 -0.47 -9.35 -0.35 1.47e-19 Coronary artery disease; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.15 -0.43 1.04e-30 Alzheimer's disease; BRCA cis rs7833986 0.534 rs2976022 chr8:57007843 T/G cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.99 0.46 2.13e-34 Height; BRCA cis rs6061231 0.798 rs2427308 chr20:60969451 C/T cg22633769 chr20:60982531 CABLES2 0.44 7.92 0.3 1.02e-14 Colorectal cancer; BRCA cis rs514406 0.505 rs374662 chr1:53164549 C/A cg24675658 chr1:53192096 ZYG11B -0.61 -14.03 -0.49 3.37e-39 Monocyte count; BRCA cis rs2243480 1.000 rs781150 chr7:65480973 C/T cg18252515 chr7:66147081 NA -0.91 -12.95 -0.46 3.02e-34 Diabetic kidney disease; BRCA cis rs17270561 0.636 rs9358880 chr6:25743161 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA trans rs1005277 0.579 rs2474588 chr10:38420870 A/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.72 -0.48 9.54e-38 Extrinsic epigenetic age acceleration; BRCA cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg00071950 chr4:10020882 SLC2A9 0.65 16.54 0.55 2.03e-51 Bone mineral density; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.06 -18.86 -0.6 1.99e-63 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs2327057 chr6:8443319 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.24e-41 Motion sickness; BRCA cis rs875971 0.929 rs34406470 chr7:65929956 A/G cg18876405 chr7:65276391 NA 0.56 13.31 0.47 7.25e-36 Aortic root size; BRCA cis rs8103278 0.793 rs59093775 chr19:46374037 G/A cg20908204 chr19:46285434 DMPK -0.28 -8.05 -0.3 4.02e-15 Coronary artery disease; BRCA cis rs875971 0.522 rs709604 chr7:65497434 A/G cg18876405 chr7:65276391 NA -0.7 -18.32 -0.59 1.36e-60 Aortic root size; BRCA cis rs858239 0.601 rs1981665 chr7:23167969 T/C cg23682824 chr7:23144976 KLHL7 0.45 12.05 0.43 2.72e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg00074818 chr8:8560427 CLDN23 0.38 8.29 0.31 6.81e-16 Obesity-related traits; BRCA cis rs6570726 0.599 rs4398765 chr6:145935006 C/A cg05347473 chr6:146136440 FBXO30 0.59 11.21 0.41 9.86e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.13 20.28 0.63 5.89e-71 Platelet count; BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg21724239 chr8:58056113 NA 0.47 8.31 0.31 5.8e-16 Developmental language disorder (linguistic errors); BRCA cis rs7646881 0.812 rs61696028 chr3:158455703 A/C cg19483011 chr3:158453295 NA -0.47 -8.26 -0.31 8.52e-16 Tetralogy of Fallot; BRCA cis rs911119 0.913 rs67483168 chr20:23581312 T/C cg16589663 chr20:23618590 CST3 0.45 8.12 0.31 2.35e-15 Chronic kidney disease; BRCA cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg02820040 chr2:241836501 C2orf54 -0.59 -11.74 -0.42 5.92e-29 Urinary metabolites; BRCA cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.55 12.97 0.46 2.45e-34 Personality dimensions; BRCA cis rs6121246 0.697 rs6088857 chr20:30226764 G/C cg13852791 chr20:30311386 BCL2L1 0.76 13.89 0.48 1.58e-38 Mean corpuscular hemoglobin; BRCA cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11644478 chr21:40555479 PSMG1 0.77 16.75 0.55 1.81e-52 Cognitive function; BRCA cis rs11690935 0.550 rs6718013 chr2:172869185 A/G cg13550731 chr2:172543902 DYNC1I2 0.5 12.22 0.44 5.17e-31 Schizophrenia; BRCA cis rs6461049 0.800 rs1860831 chr7:2160931 T/C cg00106254 chr7:1943704 MAD1L1 -0.35 -8.76 -0.33 1.71e-17 Schizophrenia; BRCA cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg14983838 chr19:29218262 NA 0.55 10.78 0.39 5.09e-25 Methadone dose in opioid dependence; BRCA trans rs6952808 0.531 rs3779003 chr7:2184902 C/T cg04565464 chr8:145669602 NFKBIL2 0.39 8.84 0.33 9.04e-18 Bipolar disorder and schizophrenia; BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg27170947 chr2:26402098 FAM59B -0.66 -11.34 -0.41 2.64e-27 Gut microbiome composition (summer); BRCA cis rs2882667 0.722 rs4835649 chr5:138146223 T/C cg04439458 chr5:138467593 SIL1 0.31 7.9 0.3 1.22e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs17376456 0.741 rs7718842 chr5:93480568 G/A cg21475434 chr5:93447410 FAM172A 0.73 8.81 0.33 1.18e-17 Diabetic retinopathy; BRCA cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg20503657 chr10:835505 NA 1.01 17.77 0.58 1.09e-57 Eosinophil percentage of granulocytes; BRCA cis rs739401 1.000 rs739401 chr11:3036324 C/T cg08508325 chr11:3079039 CARS 0.34 11.51 0.41 5.31e-28 Longevity; BRCA cis rs6748734 1.000 rs11893118 chr2:241828308 C/G cg04034577 chr2:241836375 C2orf54 -0.62 -16.03 -0.54 7.27e-49 Urinary metabolites; BRCA cis rs7666738 0.830 rs13139024 chr4:99020700 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.6 -0.32 6.14e-17 Total body bone mineral density; BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg22800045 chr5:56110881 MAP3K1 0.63 12.17 0.43 8.2e-31 Initial pursuit acceleration; BRCA cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg18876405 chr7:65276391 NA -0.62 -15.37 -0.52 1.41e-45 Aortic root size; BRCA cis rs9487051 0.768 rs463916 chr6:109520538 A/G cg01475377 chr6:109611718 NA -0.45 -11.31 -0.41 3.73e-27 Reticulocyte fraction of red cells; BRCA cis rs4664304 0.620 rs10929958 chr2:160720538 A/G cg18514922 chr2:160761262 LY75 0.33 7.89 0.3 1.29e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6138458 1.000 rs227631 chr20:24913653 A/G cg06937882 chr20:24974362 C20orf3 -0.44 -8.41 -0.32 2.76e-16 Blood protein levels; BRCA cis rs6910061 0.830 rs7762961 chr6:11109669 A/G cg27233058 chr6:11094804 LOC221710 -0.47 -8.36 -0.31 4.06e-16 Diabetic kidney disease; BRCA cis rs9814567 1.000 rs4309773 chr3:134277301 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 8.83e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs367615 0.879 rs56689485 chr5:108879828 A/T cg17395555 chr5:108820864 NA 0.37 9.39 0.35 1.03e-19 Colorectal cancer (SNP x SNP interaction); BRCA cis rs17376456 0.825 rs10214278 chr5:93237679 C/T cg25358565 chr5:93447407 FAM172A -1.08 -16.94 -0.56 1.92e-53 Diabetic retinopathy; BRCA cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.17 -0.31 1.62e-15 Gut microbiome composition (summer); BRCA cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg05283184 chr6:79620031 NA -0.41 -10.3 -0.38 4.01e-23 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg21782813 chr7:2030301 MAD1L1 0.42 11.08 0.4 3.09e-26 Bipolar disorder and schizophrenia; BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -12.62 -0.45 9.22e-33 Alzheimer's disease; BRCA cis rs12950390 0.853 rs4793647 chr17:45854090 G/C cg03474202 chr17:45855739 NA -0.48 -12.66 -0.45 6.03e-33 IgG glycosylation; BRCA cis rs7662987 0.517 rs2602866 chr4:100034997 A/G cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA trans rs11098499 0.909 rs10020034 chr4:120294331 A/G cg25214090 chr10:38739885 LOC399744 0.52 11.63 0.42 1.72e-28 Corneal astigmatism; BRCA cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg21545522 chr1:205238299 TMCC2 0.4 8.3 0.31 6.2e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg26597838 chr10:835615 NA 0.98 17.29 0.56 2.96e-55 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.897 rs8132419 chr21:40527827 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.85 0.62 1.1e-68 Cognitive function; BRCA cis rs6545883 0.929 rs10193666 chr2:61629408 C/T cg15711740 chr2:61764176 XPO1 0.54 13.51 0.47 9.33e-37 Tuberculosis; BRCA cis rs9527 0.571 rs12765337 chr10:104635344 G/C cg04362960 chr10:104952993 NT5C2 0.43 10.29 0.38 4.49e-23 Arsenic metabolism; BRCA trans rs561341 1.000 rs548957 chr17:30302411 G/A cg27661571 chr11:113659931 NA -0.7 -10.89 -0.4 1.93e-25 Hip circumference adjusted for BMI; BRCA cis rs2231884 0.697 rs11227332 chr11:65623739 A/G cg04055107 chr11:65626734 MUS81;CFL1 0.69 11.76 0.42 4.78e-29 Inflammatory bowel disease; BRCA cis rs2505998 0.833 rs2505536 chr10:43592204 A/T cg15436174 chr10:43711423 RASGEF1A 0.42 8.18 0.31 1.55e-15 Hirschsprung disease; BRCA cis rs7666738 0.861 rs10018654 chr4:99002226 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10876993 0.890 rs774891 chr12:58068571 G/A cg18357645 chr12:58087776 OS9 0.47 13.47 0.47 1.43e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg25427524 chr10:38739819 LOC399744 0.59 13.33 0.47 6.1e-36 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1008375 0.966 rs10006317 chr4:17702525 A/G cg16339924 chr4:17578868 LAP3 0.57 13.67 0.48 1.67e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs56104184 0.775 rs56149557 chr19:49401384 C/A cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg26116260 chr4:7069785 GRPEL1 0.95 28.11 0.74 9e-114 Monocyte percentage of white cells; BRCA cis rs7949030 0.626 rs35587183 chr11:62318656 C/T cg11742103 chr11:62369870 EML3;MTA2 0.53 11.22 0.41 8.32e-27 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs8114671 0.836 rs13042358 chr20:33634479 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -8.22 -0.31 1.14e-15 Height; BRCA cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg10295955 chr4:187884368 NA -0.99 -31.94 -0.78 1.62e-134 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.54 0.38 4.78e-24 Chronic sinus infection; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg00908189 chr16:619842 PIGQ 0.69 18.09 0.58 2.15e-59 Height; BRCA cis rs6089584 0.927 rs2281734 chr20:60582401 C/A cg13770153 chr20:60521292 NA -0.46 -11.06 -0.4 3.73e-26 Body mass index; BRCA cis rs12477438 1.000 rs73963398 chr2:99887025 T/C cg08885076 chr2:99613938 TSGA10 -0.48 -9.21 -0.34 4.79e-19 Chronic sinus infection; BRCA cis rs778371 0.723 rs13001052 chr2:233683984 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -16.9 -0.56 2.92e-53 Schizophrenia; BRCA trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21659725 chr3:3221576 CRBN -0.49 -12.65 -0.45 7.15e-33 Intelligence (multi-trait analysis); BRCA cis rs11055008 0.935 rs10845601 chr12:12820134 A/G cg09462578 chr12:12878428 APOLD1 0.55 12.13 0.43 1.32e-30 Pulse pressure; BRCA trans rs4650994 1.000 rs10798615 chr1:178513895 T/G cg05059571 chr16:84539110 KIAA1609 -0.43 -9.66 -0.36 1.06e-20 HDL cholesterol levels;HDL cholesterol; BRCA trans rs56011263 0.687 rs4690293 chr4:706101 A/G cg12575136 chr18:32820987 ZNF397 0.4 9.73 0.36 5.96e-21 White blood cell count; BRCA cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg05707623 chr12:122985044 ZCCHC8 -0.46 -9.52 -0.35 3.6e-20 Body mass index; BRCA cis rs11792861 0.816 rs113624314 chr9:111689953 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 7.97 0.3 7.54e-15 Menarche (age at onset); BRCA cis rs4819052 0.819 rs8134084 chr21:46693295 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg23442198 chr4:187126114 CYP4V2 -0.94 -11.4 -0.41 1.51e-27 Blood protein levels; BRCA cis rs3824867 0.676 rs7104366 chr11:47462115 G/A cg20307385 chr11:47447363 PSMC3 0.51 11.52 0.41 4.99e-28 Mean corpuscular hemoglobin; BRCA cis rs7246657 0.722 rs2909100 chr19:38212680 C/T cg23950597 chr19:37808831 NA 0.5 8.62 0.32 5.24e-17 Coronary artery calcification; BRCA cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg06046430 chr4:77819534 ANKRD56 0.56 12.58 0.45 1.35e-32 Emphysema distribution in smoking; BRCA cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA trans rs2980439 0.846 rs2980437 chr8:8094763 C/T cg16141378 chr3:129829833 LOC729375 0.39 9.34 0.35 1.59e-19 Neuroticism; BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg21143896 chr7:2802374 GNA12 -0.36 -9.11 -0.34 1.06e-18 Height; BRCA cis rs6594713 0.819 rs10061462 chr5:112726205 A/T cg12552261 chr5:112820674 MCC 0.44 7.95 0.3 8.43e-15 Brain cytoarchitecture; BRCA cis rs495337 0.760 rs11696437 chr20:48548318 C/T cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg23533926 chr12:111358616 MYL2 -0.42 -8.73 -0.33 2.26e-17 Extrinsic epigenetic age acceleration; BRCA trans rs17685 0.633 rs3801471 chr7:75696188 T/G cg19862616 chr7:65841803 NCRNA00174 0.86 28.34 0.75 4.75e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs912057 0.671 rs1294417 chr6:6741932 T/C cg06612196 chr6:6737390 NA 0.46 10.67 0.39 1.42e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs7824557 0.767 rs6985460 chr8:11171087 A/C cg21775007 chr8:11205619 TDH 0.55 10.88 0.4 2.04e-25 Retinal vascular caliber; BRCA cis rs3824867 0.804 rs12419342 chr11:47468545 C/T cg20307385 chr11:47447363 PSMC3 0.52 11.66 0.42 1.3e-28 Mean corpuscular hemoglobin; BRCA cis rs2243480 1.000 rs431318 chr7:65511597 G/A cg18252515 chr7:66147081 NA -0.97 -13.78 -0.48 5.39e-38 Diabetic kidney disease; BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg18301423 chr5:131593218 PDLIM4 0.32 8.27 0.31 7.94e-16 Breast cancer; BRCA trans rs9291683 0.546 rs13139055 chr4:10038924 G/T cg26043149 chr18:55253948 FECH 0.4 8.69 0.33 3.1e-17 Bone mineral density; BRCA trans rs1459104 1.000 rs12577585 chr11:55302603 G/A cg15704280 chr7:45808275 SEPT13 0.64 8.12 0.31 2.47e-15 Body mass index; BRCA cis rs1707322 1.000 rs12097761 chr1:46291162 T/C cg03146154 chr1:46216737 IPP 0.49 10.87 0.39 2.35e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7914558 0.966 rs2297786 chr10:104679978 C/T cg04362960 chr10:104952993 NT5C2 0.43 10.36 0.38 2.38e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs10992471 0.756 rs1121979 chr9:95140218 G/A cg14631576 chr9:95140430 CENPP -0.37 -8.99 -0.34 2.81e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA trans rs2727020 0.734 rs1164663 chr11:49294723 A/T cg15704280 chr7:45808275 SEPT13 0.69 13.9 0.48 1.38e-38 Coronary artery disease; BRCA cis rs6456156 0.586 rs12213801 chr6:167474084 T/A cg07741184 chr6:167504864 NA 0.33 9.99 0.37 6.31e-22 Primary biliary cholangitis; BRCA cis rs1997103 0.911 rs9642575 chr7:55399090 C/T cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg03709012 chr19:19516395 GATAD2A 0.82 18.95 0.6 6.56e-64 Tonsillectomy; BRCA cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg06115741 chr20:33292138 TP53INP2 0.35 7.86 0.3 1.63e-14 Glomerular filtration rate (creatinine); BRCA cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg03161606 chr19:29218774 NA 0.44 8.0 0.3 5.98e-15 Methadone dose in opioid dependence; BRCA cis rs1003719 0.715 rs9981715 chr21:38499610 C/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.28e-40 Eye color traits; BRCA cis rs2832191 0.791 rs2065270 chr21:30485420 T/C cg24692254 chr21:30365293 RNF160 -0.66 -17.89 -0.58 2.54e-58 Dental caries; BRCA trans rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -14.12 -0.49 1.27e-39 Brugada syndrome; BRCA cis rs6594499 0.542 rs4530809 chr5:110462230 A/G cg04022379 chr5:110408740 TSLP 0.37 8.39 0.32 3.11e-16 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg00166722 chr3:10149974 C3orf24 0.61 12.33 0.44 1.79e-31 Alzheimer's disease; BRCA cis rs1975991 0.711 rs2378394 chr3:187964383 T/G cg15417654 chr3:187959138 LPP 0.35 9.03 0.34 1.96e-18 White matter integrity (bipolar disorder risk interaction); BRCA cis rs12762955 0.561 rs1904671 chr10:1014603 G/A cg19847866 chr10:1019161 NA 0.55 12.0 0.43 4.72e-30 Response to angiotensin II receptor blocker therapy; BRCA cis rs6964587 0.626 rs10225241 chr7:91524940 A/G cg17063962 chr7:91808500 NA -0.55 -12.71 -0.45 3.76e-33 Breast cancer; BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg18758796 chr5:131593413 PDLIM4 0.36 8.61 0.32 5.72e-17 Acylcarnitine levels; BRCA cis rs13082711 0.513 rs66472045 chr3:27242887 G/A cg02860705 chr3:27208620 NA 0.54 10.99 0.4 7.33e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs6433895 0.736 rs11893772 chr2:181989311 C/T cg00481216 chr2:181971175 NA 0.43 9.05 0.34 1.73e-18 Lymphocyte counts; BRCA cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs9527 0.590 rs1935323 chr10:104877035 T/C cg04362960 chr10:104952993 NT5C2 0.45 10.31 0.38 3.81e-23 Arsenic metabolism; BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg00149659 chr3:10157352 C3orf10 0.8 14.11 0.49 1.53e-39 Alzheimer's disease; BRCA cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg05234568 chr11:5960015 NA -0.43 -8.83 -0.33 1.01e-17 DNA methylation (variation); BRCA cis rs7520050 0.966 rs6669522 chr1:46397941 A/G cg24296786 chr1:45957014 TESK2 0.44 9.88 0.36 1.61e-21 Red blood cell count;Reticulocyte count; BRCA cis rs9388451 0.903 rs7758115 chr6:126061502 C/T cg05901451 chr6:126070800 HEY2 -0.71 -19.69 -0.61 8.13e-68 Brugada syndrome; BRCA cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg16850897 chr7:100343110 ZAN 0.38 8.56 0.32 8.64e-17 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 18.27 0.59 2.5e-60 Platelet count; BRCA cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.54 0.47 6.44e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg06022373 chr22:39101656 GTPBP1 -0.73 -18.27 -0.59 2.61e-60 Menopause (age at onset); BRCA cis rs10174077 0.874 rs6750342 chr2:152485754 A/G cg19508488 chr2:152266495 RIF1 0.44 9.21 0.34 4.58e-19 Squamous cell lung carcinoma; BRCA cis rs2108225 0.900 rs2395930 chr7:107451677 T/C cg18560240 chr7:107437656 SLC26A3 -0.53 -11.29 -0.41 4.41e-27 Ulcerative colitis; BRCA trans rs1005277 0.602 rs2504142 chr10:38383793 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.57 -0.32 7.8e-17 Extrinsic epigenetic age acceleration; BRCA cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.47 -9.7 -0.36 7.56e-21 Monocyte percentage of white cells; BRCA cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg13395646 chr4:1353034 KIAA1530 -0.49 -8.98 -0.33 3.05e-18 Obesity-related traits; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 19.41 0.61 2.45e-66 Platelet count; BRCA cis rs9837602 0.592 rs694429 chr3:99459669 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -9.84 -0.36 2.31e-21 Breast cancer; BRCA cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg19318889 chr4:1322082 MAEA 0.49 10.4 0.38 1.62e-23 Longevity; BRCA cis rs7666738 0.830 rs7663661 chr4:99014761 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 1.000 rs9649213 chr7:98021211 A/G cg09267113 chr7:98030324 BAIAP2L1 -0.41 -11.15 -0.4 1.67e-26 Prostate cancer (SNP x SNP interaction); BRCA trans rs2727020 0.523 rs4115783 chr11:49556026 G/A cg11707556 chr5:10655725 ANKRD33B 0.43 9.66 0.36 1.05e-20 Coronary artery disease; BRCA cis rs6964587 0.692 rs2027950 chr7:91863700 C/G cg17063962 chr7:91808500 NA -0.55 -12.77 -0.45 1.94e-33 Breast cancer; BRCA cis rs6570726 0.791 rs952406 chr6:145925616 C/A cg23711669 chr6:146136114 FBXO30 0.71 16.55 0.55 1.83e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs1190552 0.894 rs1190546 chr14:102904966 A/G cg18135206 chr14:102964638 TECPR2 -0.43 -8.29 -0.31 6.82e-16 Blood protein levels; BRCA cis rs270601 0.955 rs273911 chr5:131661526 C/G cg12564285 chr5:131593104 PDLIM4 0.35 8.0 0.3 6.03e-15 Acylcarnitine levels; BRCA cis rs79976124 0.800 rs10944857 chr6:66637078 C/T cg07460842 chr6:66804631 NA 0.59 10.37 0.38 2.24e-23 Type 2 diabetes; BRCA cis rs2011503 1.000 rs11670761 chr19:19649327 G/C cg11584989 chr19:19387371 SF4 0.64 13.51 0.47 8.71e-37 Bipolar disorder; BRCA cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 0.37 7.91 0.3 1.11e-14 Osteoporosis; BRCA trans rs9929218 0.954 rs7186333 chr16:68815838 T/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.64 -13.31 -0.47 7.84e-36 Colorectal cancer; BRCA cis rs365132 0.846 rs353470 chr5:176444861 C/T cg16309518 chr5:176445507 NA -0.4 -9.71 -0.36 6.81e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs4268898 0.662 rs714531 chr2:24399877 G/A cg08917208 chr2:24149416 ATAD2B 0.53 8.27 0.31 7.97e-16 Asthma; BRCA cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg10495392 chr1:46806563 NSUN4 0.45 8.49 0.32 1.44e-16 Menopause (age at onset); BRCA cis rs2288073 0.965 rs6545335 chr2:24422011 G/A cg06627628 chr2:24431161 ITSN2 -0.65 -12.46 -0.44 4.49e-32 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.81 -0.58 6.55e-58 Chronic sinus infection; BRCA cis rs6964587 0.967 rs12538325 chr7:91757479 A/G cg17063962 chr7:91808500 NA 0.57 12.75 0.45 2.57e-33 Breast cancer; BRCA trans rs35110281 0.805 rs162402 chr21:44963418 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.37 0.31 3.6e-16 Mean corpuscular volume; BRCA cis rs9486719 0.948 rs2499813 chr6:96875338 T/C cg06623918 chr6:96969491 KIAA0776 0.73 12.97 0.46 2.56e-34 Migraine;Coronary artery disease; BRCA cis rs910316 0.763 rs175435 chr14:75612025 A/G cg11812906 chr14:75593930 NEK9 0.6 13.75 0.48 7.07e-38 Height; BRCA cis rs1949733 0.701 rs1880024 chr4:8454639 A/G cg13073564 chr4:8508604 NA -0.39 -10.61 -0.39 2.57e-24 Response to antineoplastic agents; BRCA cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg06547715 chr2:218990976 CXCR2 0.32 7.94 0.3 9.19e-15 Ulcerative colitis; BRCA trans rs208520 0.874 rs208469 chr6:66915891 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.48 -0.55 3.88e-51 Exhaled nitric oxide output; BRCA cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg26597838 chr10:835615 NA 0.5 8.71 0.33 2.68e-17 Response to angiotensin II receptor blocker therapy; BRCA cis rs1008375 0.966 rs6832414 chr4:17696866 C/G cg15017067 chr4:17643749 FAM184B 0.26 7.87 0.3 1.53e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs16866061 1.000 rs3768886 chr2:225450161 G/C cg12698349 chr2:225449008 CUL3 0.77 20.74 0.63 1.84e-73 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7165102 1.000 rs17809330 chr15:65889250 C/T cg03382306 chr15:66097959 NA 0.35 9.25 0.34 3.42e-19 Mean corpuscular hemoglobin; BRCA cis rs7267979 1.000 rs6115191 chr20:25440478 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.5 0.32 1.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9486719 0.895 rs3798294 chr6:97049587 G/A cg06623918 chr6:96969491 KIAA0776 -0.77 -13.55 -0.47 5.85e-37 Migraine;Coronary artery disease; BRCA cis rs1707322 0.963 rs4508055 chr1:46257731 A/T cg06784218 chr1:46089804 CCDC17 0.49 11.54 0.42 4.04e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11920090 0.720 rs60354090 chr3:170740217 C/T cg09710316 chr3:170744871 SLC2A2 0.64 10.46 0.38 9.42e-24 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg23992470 chr4:843637 GAK -0.53 -8.44 -0.32 2.06e-16 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs6964587 0.692 rs12536220 chr7:91805595 T/G cg17063962 chr7:91808500 NA 0.58 13.45 0.47 1.71e-36 Breast cancer; BRCA cis rs2635047 0.935 rs2635050 chr18:44664131 G/A cg19077165 chr18:44547161 KATNAL2 -0.4 -8.41 -0.32 2.69e-16 Educational attainment; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg00814883 chr7:100076585 TSC22D4 -0.49 -9.64 -0.36 1.26e-20 Platelet count; BRCA trans rs2749592 0.531 rs994804 chr10:37900140 A/C cg17830980 chr10:43048298 ZNF37B 0.35 7.91 0.3 1.17e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg16606324 chr3:10149918 C3orf24 0.55 10.79 0.39 4.78e-25 Alzheimer's disease; BRCA cis rs1451375 1.000 rs2329341 chr7:50620275 A/C cg18232548 chr7:50535776 DDC 0.44 10.2 0.37 9.99e-23 Malaria; BRCA cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg07606381 chr6:8435919 SLC35B3 0.63 13.66 0.48 1.79e-37 Motion sickness; BRCA cis rs875971 0.660 rs2013222 chr7:66035936 C/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.3 -0.31 6.3e-16 Aortic root size; BRCA cis rs858239 0.600 rs10235786 chr7:23139940 T/C cg23682824 chr7:23144976 KLHL7 0.44 11.73 0.42 6.34e-29 Cerebrospinal fluid biomarker levels; BRCA trans rs7746199 0.736 rs17750424 chr6:27701122 T/C cg06606381 chr12:133084897 FBRSL1 -0.89 -8.85 -0.33 8.51e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg11663144 chr21:46675770 NA -0.61 -13.91 -0.48 1.22e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.91 0.37 1.21e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg14036092 chr11:66035641 RAB1B 0.37 10.09 0.37 2.57e-22 Gout; BRCA cis rs4268898 0.931 rs34504814 chr2:24503766 C/T cg06627628 chr2:24431161 ITSN2 -0.52 -10.4 -0.38 1.6e-23 Asthma; BRCA cis rs2624839 0.704 rs12632110 chr3:50224225 A/G cg14019146 chr3:50243930 SLC38A3 0.53 13.72 0.48 9.62e-38 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg04455712 chr21:45112962 RRP1B -0.41 -10.87 -0.39 2.32e-25 Mean corpuscular volume; BRCA cis rs6582630 0.548 rs1607870 chr12:38385964 G/T cg26384229 chr12:38710491 ALG10B -0.43 -9.98 -0.37 6.74e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs6433895 1.000 rs55954384 chr2:182017630 A/G cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA trans rs2262909 0.962 rs73021832 chr19:22316144 G/C cg17074339 chr11:11642133 GALNTL4 0.45 8.71 0.33 2.58e-17 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs4481887 0.893 rs4244186 chr1:248493319 A/G cg00666640 chr1:248458726 OR2T12 0.33 8.99 0.34 2.75e-18 Common traits (Other); BRCA cis rs9287719 0.601 rs1861299 chr2:10763757 C/G cg00105475 chr2:10696890 NA 0.47 10.32 0.38 3.26e-23 Prostate cancer; BRCA cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg11166453 chr1:247681781 NA 0.41 9.21 0.34 4.64e-19 Acute lymphoblastic leukemia (childhood); BRCA trans rs208520 0.690 rs851464 chr6:66839802 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.02 -0.64 6.06e-75 Exhaled nitric oxide output; BRCA cis rs61931739 0.517 rs34760282 chr12:34153711 G/T cg06521331 chr12:34319734 NA -0.63 -11.51 -0.41 5.2e-28 Morning vs. evening chronotype; BRCA cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs4650994 0.525 rs2224811 chr1:178544323 C/T cg05059571 chr16:84539110 KIAA1609 0.57 12.7 0.45 4.3e-33 HDL cholesterol levels;HDL cholesterol; BRCA cis rs853679 0.517 rs1340004 chr6:28103691 C/T cg18032046 chr6:28092343 ZSCAN16 -0.49 -7.84 -0.3 1.9e-14 Depression; BRCA cis rs2180341 0.842 rs7739679 chr6:127545428 G/A cg27446573 chr6:127587934 RNF146 0.8 15.81 0.53 9.67e-48 Breast cancer; BRCA trans rs11252926 0.563 rs10904173 chr10:462885 G/A cg00953403 chr17:74099816 EXOC7 -0.5 -9.11 -0.34 1.05e-18 Psychosis in Alzheimer's disease; BRCA cis rs3617 0.591 rs11918800 chr3:52868145 G/A cg11645453 chr3:52864694 ITIH4 -0.38 -10.07 -0.37 3.01e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs7647973 1.000 rs12583 chr3:49571462 G/T cg07636037 chr3:49044803 WDR6 -0.72 -15.49 -0.52 3.34e-46 Menarche (age at onset); BRCA cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg01874867 chr7:94954059 PON1 -0.38 -7.85 -0.3 1.74e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7011049 1.000 rs72643576 chr8:53845016 A/T cg26025543 chr8:53854495 NA 0.53 9.13 0.34 8.77e-19 Systolic blood pressure; BRCA trans rs2562456 0.876 rs11668606 chr19:21737420 T/G cg25042112 chr7:64838748 ZNF92 -0.45 -8.34 -0.31 4.45e-16 Pain; BRCA cis rs2404602 0.735 rs2454454 chr15:76823647 A/G cg23625390 chr15:77176239 SCAPER -0.49 -12.69 -0.45 4.69e-33 Blood metabolite levels; BRCA cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 11.44 0.41 1.11e-27 Personality dimensions; BRCA cis rs4711336 1.000 rs764754 chr6:33658310 C/T cg14003231 chr6:33640908 ITPR3 0.32 7.86 0.3 1.69e-14 Height; BRCA cis rs4363385 0.818 rs1750309 chr1:153013630 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.38 -0.31 3.4e-16 Inflammatory skin disease; BRCA cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg17971929 chr21:40555470 PSMG1 0.77 17.92 0.58 1.83e-58 Cognitive function; BRCA cis rs826838 0.935 rs1601579 chr12:39178606 G/C cg13010199 chr12:38710504 ALG10B 0.54 11.48 0.41 7.19e-28 Heart rate; BRCA cis rs6912958 0.781 rs9450738 chr6:88267314 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.49 -0.32 1.48e-16 Monocyte percentage of white cells; BRCA trans rs7647973 0.710 rs1532204 chr3:49609477 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.86 -0.3 1.65e-14 Menarche (age at onset); BRCA cis rs10206020 0.921 rs10177509 chr2:1568536 T/C cg12573674 chr2:1569213 NA -0.63 -14.05 -0.49 2.77e-39 IgG glycosylation; BRCA cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg05347473 chr6:146136440 FBXO30 0.4 7.87 0.3 1.52e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.875 rs9403770 chr6:146423334 C/T cg23711669 chr6:146136114 FBXO30 0.76 17.46 0.57 3.96e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs11711311 0.955 rs9813630 chr3:113377361 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.02 -0.37 4.72e-22 IgG glycosylation; BRCA cis rs17401966 0.838 rs1556916 chr1:10403482 G/A cg19773385 chr1:10388646 KIF1B -0.35 -7.81 -0.3 2.31e-14 Hepatocellular carcinoma; BRCA cis rs2243480 1.000 rs68189316 chr7:65409169 C/G cg18252515 chr7:66147081 NA -0.84 -12.12 -0.43 1.34e-30 Diabetic kidney disease; BRCA cis rs13108904 0.539 rs13140926 chr4:1340939 G/A cg13395646 chr4:1353034 KIAA1530 -0.51 -9.16 -0.34 7.21e-19 Obesity-related traits; BRCA cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.42 0.54 8.08e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs10504229 1.000 rs115548028 chr8:58170672 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.48 -0.32 1.51e-16 Developmental language disorder (linguistic errors); BRCA cis rs1580019 0.961 rs4460271 chr7:32496503 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.08 0.54 4.26e-49 Cognitive ability; BRCA cis rs7103648 0.553 rs12803857 chr11:47890172 G/A cg03711944 chr11:47377212 SPI1 -0.41 -9.49 -0.35 4.42e-20 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs8062405 0.824 rs28698667 chr16:28533071 C/T cg16576597 chr16:28551801 NUPR1 0.31 8.5 0.32 1.32e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs801193 0.569 rs10950050 chr7:66239588 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.21 0.31 1.26e-15 Aortic root size; BRCA cis rs365132 0.875 rs2456178 chr5:176413570 C/G cg16309518 chr5:176445507 NA -0.52 -13.35 -0.47 4.77e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2991971 0.933 rs12568144 chr1:45965307 G/A cg24296786 chr1:45957014 TESK2 0.64 15.85 0.53 5.88e-48 High light scatter reticulocyte count; BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.76 0.48 6.16e-38 Platelet count; BRCA cis rs61990749 0.544 rs176979 chr14:78198072 A/C cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.97 0.3 7.37e-15 Fibroblast growth factor basic levels; BRCA cis rs57590327 0.503 rs12638997 chr3:81844912 A/G cg07356753 chr3:81810745 GBE1 -0.45 -10.53 -0.38 4.97e-24 Extraversion; BRCA cis rs3772130 0.962 rs9822949 chr3:121541239 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.97 0.4 9.17e-26 Cognitive performance; BRCA cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg27165867 chr14:105738592 BRF1 -0.37 -8.61 -0.32 5.47e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg09469691 chr10:81107165 PPIF 0.44 9.56 0.35 2.41e-20 Height; BRCA cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg20701182 chr2:24300061 SF3B14 0.57 9.01 0.34 2.39e-18 Lymphocyte counts; BRCA cis rs372883 0.530 rs2832305 chr21:30752964 G/A cg08807101 chr21:30365312 RNF160 0.37 8.33 0.31 4.75e-16 Pancreatic cancer; BRCA cis rs62244186 0.516 rs11922470 chr3:44777795 C/T cg02073558 chr3:44770973 ZNF501 0.5 10.44 0.38 1.18e-23 Depressive symptoms; BRCA cis rs1580019 0.961 rs11765387 chr7:32494790 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.5 0.32 1.32e-16 Cognitive ability; BRCA cis rs679087 1.000 rs679087 chr12:29917265 C/A cg14258853 chr12:29935411 TMTC1 -0.42 -8.85 -0.33 8.36e-18 Schizophrenia; BRCA cis rs16854884 0.633 rs6779321 chr3:143736676 T/C cg06585982 chr3:143692056 C3orf58 0.43 8.99 0.33 2.87e-18 Economic and political preferences (feminism/equality); BRCA cis rs7666738 0.830 rs13124127 chr4:98990729 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.51 0.55 2.9e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs7572733 0.534 rs700685 chr2:198715972 A/G cg00792783 chr2:198669748 PLCL1 0.46 10.16 0.37 1.39e-22 Dermatomyositis; BRCA cis rs734999 0.967 rs4486391 chr1:2513055 A/T cg20673091 chr1:2541236 MMEL1 0.35 9.23 0.34 3.78e-19 Ulcerative colitis; BRCA cis rs12618769 0.597 rs72821907 chr2:99085296 A/G cg10123293 chr2:99228465 UNC50 0.41 8.05 0.3 4.12e-15 Bipolar disorder; BRCA cis rs2777491 0.507 rs11854081 chr15:41646398 C/T cg18705301 chr15:41695430 NDUFAF1 -1.07 -26.3 -0.72 7.28e-104 Ulcerative colitis; BRCA cis rs796364 1.000 rs35594306 chr2:200775125 T/C cg23649088 chr2:200775458 C2orf69 -0.61 -7.95 -0.3 8.69e-15 Schizophrenia; BRCA cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.27 0.31 7.51e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2576037 0.583 rs2156049 chr18:44455717 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.69 0.5 2.55e-42 Personality dimensions; BRCA cis rs67460515 0.859 rs7610800 chr3:161002582 C/T cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Parkinson's disease; BRCA cis rs644148 0.770 rs2571113 chr19:44999814 A/G cg15540054 chr19:45004280 ZNF180 -0.57 -12.28 -0.44 2.9e-31 Personality dimensions; BRCA cis rs9733 0.621 rs12746899 chr1:150579678 A/T cg18016565 chr1:150552671 MCL1 -0.45 -9.97 -0.37 7.39e-22 Tonsillectomy; BRCA cis rs9790314 0.747 rs7619011 chr3:160855676 A/G cg03342759 chr3:160939853 NMD3 -0.52 -10.41 -0.38 1.53e-23 Morning vs. evening chronotype; BRCA cis rs40363 0.645 rs250630 chr16:3524242 C/T cg00484396 chr16:3507460 NAT15 0.43 9.04 0.34 1.86e-18 Tuberculosis; BRCA cis rs4891159 0.757 rs11665018 chr18:74123589 C/T cg24786174 chr18:74118243 ZNF516 -0.78 -18.93 -0.6 9.23e-64 Longevity; BRCA cis rs7945705 0.902 rs2568059 chr11:8884161 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.81 -0.51 7.04e-43 Hemoglobin concentration; BRCA cis rs9815354 0.812 rs113300894 chr3:41984243 G/C cg03022575 chr3:42003672 ULK4 0.73 9.9 0.36 1.36e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg03433033 chr1:76189801 ACADM -0.57 -11.41 -0.41 1.46e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3099143 1.000 rs1913001 chr15:77179408 A/C cg21673338 chr15:77095150 SCAPER 0.52 9.14 0.34 7.87e-19 Recalcitrant atopic dermatitis; BRCA cis rs953387 0.910 rs72976292 chr2:136929107 T/A cg05194412 chr2:137003533 NA -0.35 -8.02 -0.3 4.98e-15 Arthritis (juvenile idiopathic); BRCA cis rs9788721 0.836 rs17483721 chr15:78733731 C/T cg18825076 chr15:78729989 IREB2 0.38 7.92 0.3 1.03e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs11105298 0.891 rs10777163 chr12:89830720 T/C cg00757033 chr12:89920650 WDR51B 0.42 8.8 0.33 1.25e-17 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg23285459 chr7:2802560 GNA12 -0.37 -9.33 -0.35 1.75e-19 Height; BRCA cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.35 9.82 0.36 2.8e-21 Monocyte percentage of white cells; BRCA cis rs911555 0.723 rs6575991 chr14:103908433 C/T cg12935359 chr14:103987150 CKB 0.65 15.04 0.51 5.37e-44 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg22764044 chr5:178986830 RUFY1 0.46 12.35 0.44 1.46e-31 Lung cancer; BRCA cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.16 0.31 1.76e-15 Menopause (age at onset); BRCA cis rs858239 0.600 rs10237755 chr7:23131564 A/G cg23682824 chr7:23144976 KLHL7 0.45 12.23 0.44 4.63e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs7809950 1.000 rs987391 chr7:107100794 C/G cg23024343 chr7:107201750 COG5 -0.4 -9.3 -0.35 2.24e-19 Coronary artery disease; BRCA cis rs17401966 0.838 rs4623 chr1:10366692 C/G cg03954927 chr1:10346856 KIF1B 0.43 13.74 0.48 8.33e-38 Hepatocellular carcinoma; BRCA trans rs2204008 0.837 rs2387317 chr12:38235319 T/C cg06521331 chr12:34319734 NA -0.49 -9.07 -0.34 1.51e-18 Bladder cancer; BRCA cis rs12681288 0.676 rs17740799 chr8:1014327 C/T cg04851639 chr8:1020857 NA 0.39 11.25 0.41 6.21e-27 Schizophrenia; BRCA cis rs807669 0.525 rs9605955 chr22:19181557 C/T cg02655711 chr22:19163373 SLC25A1 0.45 10.3 0.38 3.9e-23 Metabolite levels; BRCA cis rs9291683 0.507 rs3775940 chr4:10025163 A/T cg11266682 chr4:10021025 SLC2A9 0.46 12.57 0.45 1.57e-32 Bone mineral density; BRCA cis rs13064411 0.696 rs13325046 chr3:113104444 C/T cg18753928 chr3:113234510 CCDC52 -0.52 -9.43 -0.35 7.25e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg16414030 chr3:133502952 NA -0.54 -12.95 -0.46 3.25e-34 Iron status biomarkers; BRCA cis rs875971 1.000 rs2036264 chr7:65799904 G/A cg11764359 chr7:65958608 NA -0.8 -19.34 -0.61 5.76e-66 Aortic root size; BRCA cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg16339924 chr4:17578868 LAP3 0.58 14.15 0.49 9.29e-40 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg24082983 chr21:31802169 KRTAP13-4 0.35 8.99 0.34 2.79e-18 HDL cholesterol; BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26314531 chr2:26401878 FAM59B -0.66 -11.2 -0.4 1.08e-26 Gut microbiome composition (summer); BRCA cis rs12142240 0.659 rs17361873 chr1:46832686 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.34 -0.35 1.55e-19 Menopause (age at onset); BRCA cis rs9733 0.566 rs11204675 chr1:150570985 A/C cg13175981 chr1:150552382 MCL1 0.42 9.4 0.35 9.95e-20 Tonsillectomy; BRCA cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs6430585 0.527 rs1900306 chr2:136416533 G/A cg07169764 chr2:136633963 MCM6 1.13 21.95 0.66 5.05e-80 Corneal structure; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg25036284 chr2:26402008 FAM59B -0.67 -10.99 -0.4 7.66e-26 Gut microbiome composition (summer); BRCA cis rs1050631 0.564 rs12185396 chr18:33738496 C/T cg25426722 chr18:33708991 SLC39A6;ELP2 0.38 7.9 0.3 1.2e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs6831352 0.734 rs2851259 chr4:100033986 C/T cg13256891 chr4:100009986 ADH5 0.5 10.35 0.38 2.51e-23 Alcohol dependence; BRCA cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg25817165 chr18:72167213 CNDP2 -0.75 -14.62 -0.5 5.74e-42 Refractive error; BRCA cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.08e-15 Alzheimer's disease (late onset); BRCA cis rs826838 0.967 rs10875979 chr12:39095149 G/A cg13010199 chr12:38710504 ALG10B 0.43 10.2 0.37 9.44e-23 Heart rate; BRCA cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs629535 0.699 rs539956 chr8:70033647 G/A cg21567404 chr3:27674614 NA 1.0 21.04 0.64 4.79e-75 Dupuytren's disease; BRCA cis rs514406 0.858 rs574853 chr1:53310959 A/T cg24675658 chr1:53192096 ZYG11B -0.51 -11.25 -0.41 6.66e-27 Monocyte count; BRCA cis rs10197940 0.624 rs13393122 chr2:152413315 A/G cg06191203 chr2:152266755 RIF1 -0.42 -11.96 -0.43 7.13e-30 Lung cancer; BRCA cis rs1215050 0.740 rs6854802 chr4:99065480 A/C cg05340658 chr4:99064831 C4orf37 0.48 11.11 0.4 2.54e-26 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2019137 0.560 rs11123172 chr2:113984303 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.65 -13.59 -0.47 3.79e-37 Lymphocyte counts; BRCA cis rs13108904 0.870 rs2279281 chr4:1245277 T/G cg05665937 chr4:1216051 CTBP1 0.37 7.82 0.3 2.2e-14 Obesity-related traits; BRCA cis rs7254114 0.578 rs4804574 chr19:11317482 G/A cg02815516 chr19:11306319 KANK2 0.34 9.89 0.36 1.45e-21 Immature fraction of reticulocytes; BRCA cis rs3820928 0.810 rs10175929 chr2:227858609 T/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.42 -0.32 2.41e-16 Pulmonary function; BRCA cis rs34779708 1.000 rs34779708 chr10:35466185 T/G cg03585969 chr10:35415529 CREM 0.49 10.4 0.38 1.68e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg00102166 chr1:43425337 SLC2A1 -0.51 -8.87 -0.33 7.3e-18 Monocyte count; BRCA cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg11584989 chr19:19387371 SF4 0.62 13.0 0.46 1.89e-34 Bipolar disorder; BRCA trans rs3960554 0.932 rs4728597 chr7:75821062 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 11.55 0.42 3.67e-28 Eotaxin levels; BRCA cis rs6963495 0.556 rs711427 chr7:105161755 T/G cg19920283 chr7:105172520 RINT1 0.44 9.16 0.34 6.84e-19 Bipolar disorder (body mass index interaction); BRCA cis rs4481887 0.927 rs12042598 chr1:248482016 C/T cg13385794 chr1:248469461 NA 0.27 7.97 0.3 7.54e-15 Common traits (Other); BRCA cis rs10789491 1.000 rs1890473 chr1:47149794 C/T cg15501359 chr1:47185051 KIAA0494 0.62 17.31 0.57 2.41e-55 Response to hepatitis C treatment; BRCA cis rs7580658 0.545 rs885276 chr2:127950904 A/T cg16751203 chr2:127950803 CYP27C1 0.29 8.32 0.31 5.28e-16 Protein C levels; BRCA cis rs1468333 1.000 rs17171770 chr5:137514815 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.44 8.73 0.33 2.15e-17 Resting heart rate; BRCA cis rs701145 0.585 rs357494 chr3:153937753 G/A cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs1707322 0.682 rs28490344 chr1:46197948 C/T cg03146154 chr1:46216737 IPP 0.54 12.03 0.43 3.34e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.85 -0.3 1.82e-14 Colorectal cancer; BRCA cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg04455712 chr21:45112962 RRP1B 0.37 9.45 0.35 6.3e-20 Mean corpuscular volume; BRCA cis rs11690935 0.921 rs7355523 chr2:172744421 T/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -27.64 -0.74 3.21e-111 Schizophrenia; BRCA cis rs11696845 0.787 rs6017408 chr20:43363529 A/G cg25301532 chr20:43378953 KCNK15 0.33 7.96 0.3 7.8e-15 Obesity-related traits; BRCA cis rs6138458 1.000 rs227630 chr20:24913584 A/G cg26195577 chr20:24973756 C20orf3 0.98 24.67 0.7 6.47e-95 Blood protein levels; BRCA cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg08807101 chr21:30365312 RNF160 -0.44 -9.45 -0.35 6.49e-20 Pancreatic cancer; BRCA cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.08 -0.3 3.14e-15 Menarche (age at onset); BRCA cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs897080 0.514 rs1067376 chr2:44648361 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.41 0.35 9.08e-20 Height; BRCA cis rs1707322 0.686 rs2050376 chr1:46078630 C/T cg06784218 chr1:46089804 CCDC17 0.54 12.73 0.45 2.89e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1011018 0.554 rs56124209 chr7:139463275 C/G cg03224163 chr7:139420300 HIPK2 -0.59 -8.83 -0.33 1.01e-17 Systolic blood pressure; BRCA cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg22535103 chr8:58192502 C8orf71 -0.47 -9.24 -0.34 3.68e-19 Developmental language disorder (linguistic errors); BRCA cis rs11679564 0.714 rs4670638 chr2:37164911 C/G cg14987922 chr2:37194071 STRN 0.4 8.57 0.32 8.05e-17 Immature fraction of reticulocytes; BRCA cis rs5167 0.505 rs7257468 chr19:45453144 C/T cg09555818 chr19:45449301 APOC2 0.47 12.22 0.44 5.19e-31 Blood protein levels; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg26516362 chr5:178986906 RUFY1 0.37 10.35 0.38 2.62e-23 Lung cancer; BRCA trans rs9929218 0.551 rs3785135 chr16:68728976 A/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.99 -31.25 -0.78 7.75e-131 Colorectal cancer; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg04013093 chr6:42928303 GNMT -0.29 -8.84 -0.33 9.55e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9287719 0.967 rs12464817 chr2:10707212 A/G cg00105475 chr2:10696890 NA 0.44 10.21 0.37 9.17e-23 Prostate cancer; BRCA trans rs11098499 0.754 rs7689729 chr4:120256192 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.6 0.39 2.72e-24 Corneal astigmatism; BRCA cis rs2404602 0.647 rs12913024 chr15:77145216 C/T cg23625390 chr15:77176239 SCAPER -0.56 -13.0 -0.46 1.98e-34 Blood metabolite levels; BRCA cis rs919433 0.680 rs7568250 chr2:198409611 G/A cg00792783 chr2:198669748 PLCL1 0.39 8.61 0.32 5.66e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6963495 0.932 rs55700120 chr7:105148460 G/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.07e-19 Bipolar disorder (body mass index interaction); BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.56 -0.32 8.42e-17 Total body bone mineral density; BRCA cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg20607798 chr8:58055168 NA 0.46 8.13 0.31 2.32e-15 Developmental language disorder (linguistic errors); BRCA cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg00339695 chr16:24857497 SLC5A11 -0.52 -11.1 -0.4 2.61e-26 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.597 rs11722989 chr4:10126139 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -9.84 -0.36 2.37e-21 Bone mineral density; BRCA cis rs6088590 0.735 rs6060003 chr20:33294945 T/C cg24642439 chr20:33292090 TP53INP2 0.53 11.34 0.41 2.69e-27 Coronary artery disease; BRCA cis rs2276314 1.000 rs4573997 chr18:33552568 C/T cg19628046 chr18:33552617 C18orf21 0.63 12.99 0.46 2.07e-34 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.88 13.89 0.48 1.53e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11229555 0.645 rs11229429 chr11:58180872 G/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6460942 0.915 rs62447638 chr7:12484667 G/A cg06484146 chr7:12443880 VWDE -0.76 -10.58 -0.39 3.2e-24 Coronary artery disease; BRCA cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -12.13 -0.43 1.3e-30 Personality dimensions; BRCA cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg01849466 chr14:104193079 ZFYVE21 -0.42 -10.83 -0.39 3.19e-25 Schizophrenia; BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA trans rs3857536 0.740 rs7766407 chr6:66885658 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.49 -9.77 -0.36 4.07e-21 Blood trace element (Cu levels); BRCA cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg15145296 chr3:125709740 NA -0.54 -8.57 -0.32 7.5e-17 Blood pressure (smoking interaction); BRCA cis rs4588572 0.643 rs11744479 chr5:77729220 T/G cg11547950 chr5:77652471 NA -0.46 -8.11 -0.31 2.58e-15 Triglycerides; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg11814155 chr7:99998594 ZCWPW1 0.51 9.1 0.34 1.16e-18 Platelet count; BRCA cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg01528321 chr10:82214614 TSPAN14 0.65 14.66 0.5 3.84e-42 Post bronchodilator FEV1; BRCA cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.43 0.52 6.96e-46 Colorectal cancer; BRCA cis rs6121246 0.559 rs6119652 chr20:30259445 C/G cg21427119 chr20:30132790 HM13 -0.36 -8.17 -0.31 1.71e-15 Mean corpuscular hemoglobin; BRCA cis rs10504229 0.728 rs72650856 chr8:58152695 C/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs4911259 0.552 rs13038017 chr20:31467551 T/C cg13636640 chr20:31349939 DNMT3B -0.45 -11.95 -0.43 7.56e-30 Inflammatory bowel disease; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg03188948 chr7:1209495 NA 0.55 9.32 0.35 1.91e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg03929089 chr4:120376271 NA 0.5 8.22 0.31 1.18e-15 Axial length; BRCA cis rs12618769 0.681 rs72823792 chr2:99215142 G/A cg10123293 chr2:99228465 UNC50 0.42 8.53 0.32 1.07e-16 Bipolar disorder; BRCA cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg15782153 chr7:917662 C7orf20 0.43 10.38 0.38 1.95e-23 Perceived unattractiveness to mosquitoes; BRCA cis rs698813 0.756 rs2592196 chr2:44605522 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.93 0.37 1.02e-21 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs1499614 0.803 rs1796229 chr7:66119661 G/A cg18252515 chr7:66147081 NA -1.07 -15.86 -0.53 5.14e-48 Gout; BRCA cis rs11190604 1.000 rs2489036 chr10:102319581 A/G cg07080220 chr10:102295463 HIF1AN 0.6 14.26 0.49 3.07e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs939658 0.805 rs11635757 chr15:79432737 T/C cg17916960 chr15:79447300 NA -0.44 -11.18 -0.4 1.28e-26 Refractive error; BRCA cis rs61931739 0.500 rs10772154 chr12:34373271 A/C cg06521331 chr12:34319734 NA -0.52 -10.32 -0.38 3.33e-23 Morning vs. evening chronotype; BRCA cis rs10046574 0.561 rs10215176 chr7:135198589 A/G cg27474649 chr7:135195673 CNOT4 0.67 10.95 0.4 1.07e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg06636001 chr8:8085503 FLJ10661 -0.51 -11.34 -0.41 2.89e-27 Systolic blood pressure; BRCA trans rs2204008 0.837 rs7301679 chr12:37989629 T/C cg06521331 chr12:34319734 NA 0.44 8.75 0.33 1.96e-17 Bladder cancer; BRCA cis rs6582630 0.519 rs11181294 chr12:38312787 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -8.94 -0.33 4.23e-18 Developmental language disorder (linguistic errors); BRCA cis rs7100689 0.524 rs7902460 chr10:82199263 T/A cg01528321 chr10:82214614 TSPAN14 0.73 16.66 0.55 5.29e-52 Post bronchodilator FEV1; BRCA cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg23583168 chr7:148888333 NA -0.85 -19.78 -0.62 2.74e-68 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7944584 0.837 rs11039149 chr11:47276675 A/G cg20307385 chr11:47447363 PSMC3 0.63 11.91 0.43 1.1e-29 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs524281 0.861 rs11607393 chr11:65875149 C/A cg16950941 chr11:66035639 RAB1B -0.39 -8.16 -0.31 1.8e-15 Electroencephalogram traits; BRCA cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg02466173 chr16:30829666 NA -0.44 -9.77 -0.36 4.18e-21 Dementia with Lewy bodies; BRCA cis rs26868 0.690 rs26835 chr16:2237549 C/T cg07587117 chr16:2239488 CASKIN1 0.37 8.07 0.3 3.5e-15 Height; BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17345786 0.906 rs56171035 chr3:101111108 G/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.56 11.29 0.41 4.32e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs3820928 0.874 rs12105952 chr2:227864521 G/A cg11843606 chr2:227700838 RHBDD1 -0.39 -8.44 -0.32 2.21e-16 Pulmonary function; BRCA cis rs55665837 1.000 rs10832271 chr11:14466919 C/G cg19336497 chr11:14380999 RRAS2 -0.37 -9.77 -0.36 4.22e-21 Vitamin D levels; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg27170947 chr2:26402098 FAM59B 0.95 16.36 0.54 1.59e-50 Gut microbiome composition (summer); BRCA cis rs67478160 0.643 rs11160762 chr14:104255083 A/G cg08213375 chr14:104286397 PPP1R13B -0.65 -18.77 -0.6 6.24e-63 Schizophrenia; BRCA cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg00409905 chr10:38381863 ZNF37A -0.49 -10.42 -0.38 1.34e-23 Extrinsic epigenetic age acceleration; BRCA cis rs35306767 0.953 rs12354639 chr10:963681 G/A cg25019033 chr10:957182 NA -0.42 -8.74 -0.33 2.01e-17 Eosinophil percentage of granulocytes; BRCA cis rs1153858 1.000 rs12437840 chr15:45669055 C/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.79 0.42 3.68e-29 Homoarginine levels; BRCA cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg24450063 chr1:156163899 SLC25A44 1.1 34.38 0.81 1.92e-147 Testicular germ cell tumor; BRCA cis rs7264396 0.790 rs6060526 chr20:34225302 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.7 14.01 0.48 4.45e-39 Total cholesterol levels; BRCA cis rs801193 0.904 rs4718403 chr7:66242729 C/G cg11764359 chr7:65958608 NA 0.67 14.95 0.51 1.51e-43 Aortic root size; BRCA cis rs7677751 0.767 rs11133315 chr4:55082158 G/A cg17187183 chr4:55093834 PDGFRA 0.45 9.0 0.34 2.65e-18 Corneal astigmatism; BRCA cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg05347473 chr6:146136440 FBXO30 -0.44 -8.81 -0.33 1.17e-17 Lobe attachment (rater-scored or self-reported); BRCA trans rs747782 0.527 rs2279822 chr11:48146114 C/T cg15704280 chr7:45808275 SEPT13 0.58 8.16 0.31 1.75e-15 Intraocular pressure; BRCA cis rs2439831 0.850 rs7168158 chr15:44050376 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.78 0.36 3.89e-21 Lung cancer in ever smokers; BRCA cis rs72781680 0.898 rs6545127 chr2:24060670 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.05 0.34 1.77e-18 Lymphocyte counts; BRCA cis rs9297145 1.000 rs10953280 chr7:98763405 A/G cg05967295 chr7:98741636 SMURF1 -0.88 -20.87 -0.64 3.56e-74 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg08470875 chr2:26401718 FAM59B -0.68 -11.53 -0.41 4.61e-28 Gut microbiome composition (summer); BRCA cis rs2629540 0.847 rs12762597 chr10:126387043 G/A cg08799069 chr10:126477246 METTL10 0.45 9.13 0.34 9e-19 Cocaine dependence; BRCA trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg03929089 chr4:120376271 NA -0.48 -9.03 -0.34 2.02e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.5 -0.32 1.38e-16 Developmental language disorder (linguistic errors); BRCA cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg24110177 chr3:50126178 RBM5 -0.51 -14.18 -0.49 7.09e-40 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg20607798 chr8:58055168 NA 0.46 8.08 0.3 3.19e-15 Developmental language disorder (linguistic errors); BRCA cis rs9837602 0.938 rs9873709 chr3:99711687 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.6 0.39 2.68e-24 Breast cancer; BRCA cis rs6120849 0.901 rs6088738 chr20:33747331 A/G cg24642439 chr20:33292090 TP53INP2 -0.47 -8.62 -0.32 5.22e-17 Protein C levels; BRCA cis rs61990749 0.544 rs1477259 chr14:78256138 C/G cg02301378 chr14:78227641 SNW1;C14orf178 0.58 9.29 0.34 2.41e-19 Fibroblast growth factor basic levels; BRCA cis rs6430585 0.583 rs3769013 chr2:136556182 C/T cg07169764 chr2:136633963 MCM6 1.22 28.11 0.74 8.76e-114 Corneal structure; BRCA cis rs34779708 0.931 rs4934723 chr10:35381763 A/G cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA trans rs3733585 0.699 rs12498956 chr4:9950705 G/T cg26043149 chr18:55253948 FECH -0.36 -8.06 -0.3 3.82e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.85 0.42 2.03e-29 Lung cancer in ever smokers; BRCA cis rs35110281 0.837 rs7279958 chr21:45016016 C/A cg01579765 chr21:45077557 HSF2BP -0.42 -11.61 -0.42 2.03e-28 Mean corpuscular volume; BRCA cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.33 -8.9 -0.33 5.68e-18 Monocyte percentage of white cells; BRCA cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA trans rs17685 0.535 rs41299460 chr7:75600951 G/A cg19862616 chr7:65841803 NCRNA00174 0.38 9.09 0.34 1.25e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9318086 0.648 rs7331047 chr13:24467342 T/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.3 8.44 0.32 2.13e-16 Myopia (pathological); BRCA trans rs4650994 0.544 rs2811314 chr1:178619183 C/T cg05059571 chr16:84539110 KIAA1609 0.53 11.88 0.43 1.45e-29 HDL cholesterol levels;HDL cholesterol; BRCA cis rs36051895 0.625 rs12340333 chr9:5176215 C/G cg02405213 chr9:5042618 JAK2 -0.46 -8.9 -0.33 5.92e-18 Pediatric autoimmune diseases; BRCA cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.27 0.59 2.7e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs9814567 0.806 rs2293293 chr3:134322742 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.77 -0.33 1.65e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg09359103 chr1:154839909 KCNN3 -0.56 -14.71 -0.5 2.03e-42 Prostate cancer; BRCA cis rs17253792 0.822 rs10136155 chr14:56049129 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.58 7.84 0.3 1.92e-14 Putamen volume; BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg26119090 chr2:26468346 HADHA;HADHB 0.75 11.73 0.42 6.29e-29 Gut microbiome composition (summer); BRCA cis rs2204008 0.539 rs1283295 chr12:38146014 A/C cg26384229 chr12:38710491 ALG10B -0.44 -10.05 -0.37 3.71e-22 Bladder cancer; BRCA cis rs9487051 0.676 rs9320278 chr6:109562589 T/C cg21918786 chr6:109611834 NA -0.31 -7.97 -0.3 7.24e-15 Reticulocyte fraction of red cells; BRCA cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg09359103 chr1:154839909 KCNN3 -0.59 -15.31 -0.52 2.79e-45 Prostate cancer; BRCA cis rs7264396 0.561 rs6060741 chr20:34571484 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.54 10.06 0.37 3.37e-22 Total cholesterol levels; BRCA trans rs11992162 1.000 rs7460395 chr8:11835375 C/T cg06636001 chr8:8085503 FLJ10661 0.45 8.9 0.33 5.83e-18 Monocyte count; BRCA cis rs919433 0.680 rs2244271 chr2:198286581 C/T cg00792783 chr2:198669748 PLCL1 0.39 8.66 0.32 3.9e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg00814883 chr7:100076585 TSC22D4 -0.55 -10.74 -0.39 7.84e-25 Platelet count; BRCA trans rs9291683 0.588 rs35438220 chr4:9999398 C/T cg26043149 chr18:55253948 FECH 0.41 8.88 0.33 6.69e-18 Bone mineral density; BRCA cis rs6893300 0.785 rs7704520 chr5:179191054 G/A cg14593053 chr5:179126677 CANX -0.36 -8.09 -0.3 2.9e-15 Resting heart rate; BRCA cis rs113835537 0.627 rs11227534 chr11:66336171 C/A cg24851651 chr11:66362959 CCS 0.43 8.17 0.31 1.65e-15 Airway imaging phenotypes; BRCA cis rs2204008 0.623 rs1315348 chr12:38163044 G/A cg26384229 chr12:38710491 ALG10B -0.46 -10.54 -0.38 4.82e-24 Bladder cancer; BRCA cis rs4481887 1.000 rs4508046 chr1:248488988 T/C cg00666640 chr1:248458726 OR2T12 0.34 9.11 0.34 1.03e-18 Common traits (Other); BRCA cis rs9527 0.569 rs10883801 chr10:104677887 A/C cg04362960 chr10:104952993 NT5C2 0.45 10.36 0.38 2.38e-23 Arsenic metabolism; BRCA cis rs6484504 0.625 rs1535741 chr11:31375072 T/C cg06552810 chr11:31128660 NA 0.38 8.53 0.32 1.06e-16 Red blood cell count; BRCA cis rs4363385 0.818 rs529077 chr1:153012149 T/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA trans rs9388451 0.839 rs10457469 chr6:126083658 G/A cg05039488 chr6:79577232 IRAK1BP1 -0.51 -11.86 -0.42 1.78e-29 Brugada syndrome; BRCA cis rs72781680 0.821 rs17038360 chr2:24095798 A/G cg08917208 chr2:24149416 ATAD2B 0.61 10.4 0.38 1.59e-23 Lymphocyte counts; BRCA cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg08885076 chr2:99613938 TSGA10 -0.49 -9.45 -0.35 6.45e-20 Chronic sinus infection; BRCA cis rs919433 0.680 rs2565163 chr2:198354414 T/C cg00792783 chr2:198669748 PLCL1 0.39 8.67 0.32 3.56e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10876993 0.680 rs2277322 chr12:58009202 T/C cg18357645 chr12:58087776 OS9 -0.36 -9.43 -0.35 7.16e-20 Celiac disease or Rheumatoid arthritis; BRCA cis rs13191362 1.000 rs67487119 chr6:163102657 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.99 14.92 0.51 2.08e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg03146154 chr1:46216737 IPP 0.54 12.02 0.43 3.81e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs3749237 1.000 rs11710675 chr3:49751900 C/A cg21659725 chr3:3221576 CRBN 0.51 12.1 0.43 1.72e-30 Resting heart rate; BRCA cis rs875971 0.545 rs316316 chr7:65614257 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.96 -0.37 7.78e-22 Aortic root size; BRCA cis rs7617480 0.519 rs6790914 chr3:49206318 G/C cg06212747 chr3:49208901 KLHDC8B 0.68 14.76 0.5 1.25e-42 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs10046574 0.634 rs77474267 chr7:135098679 G/A cg27474649 chr7:135195673 CNOT4 0.58 8.33 0.31 5.1e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9393777 0.623 rs2093169 chr6:26495099 C/T cg12826209 chr6:26865740 GUSBL1 0.56 9.19 0.34 5.36e-19 Intelligence (multi-trait analysis); BRCA trans rs1974653 0.781 rs9606245 chr22:20084681 G/A cg20152630 chr19:46405944 MYPOP 0.38 8.48 0.32 1.6e-16 Schizophrenia; BRCA cis rs875971 0.830 rs6950137 chr7:65976610 G/A cg18876405 chr7:65276391 NA 0.51 11.4 0.41 1.57e-27 Aortic root size; BRCA cis rs36051895 0.632 rs62541916 chr9:5151904 C/A cg02405213 chr9:5042618 JAK2 -0.44 -8.57 -0.32 7.72e-17 Pediatric autoimmune diseases; BRCA cis rs6910233 0.793 rs210133 chr6:33536797 C/G cg13560919 chr6:33536144 NA 0.37 7.88 0.3 1.45e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg26818010 chr10:134567672 INPP5A -0.63 -13.42 -0.47 2.27e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs11098499 0.820 rs12503082 chr4:120284317 A/G cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs34375054 0.624 rs7132026 chr12:125678096 A/G cg25124228 chr12:125621409 AACS 0.43 8.31 0.31 5.95e-16 Post bronchodilator FEV1/FVC ratio; BRCA cis rs10883723 0.810 rs7079810 chr10:104243883 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.97 0.58 9.63e-59 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2658782 0.951 rs2608214 chr11:93148665 C/T cg15737290 chr11:93063684 CCDC67 0.47 9.51 0.35 3.92e-20 Pulmonary function decline; BRCA cis rs7945718 0.810 rs7930282 chr11:12835941 C/T cg25843174 chr11:12811716 TEAD1 0.21 8.22 0.31 1.17e-15 Educational attainment (years of education); BRCA cis rs4919087 1.000 rs61863767 chr10:99084426 C/T cg25902810 chr10:99078978 FRAT1 0.51 10.82 0.39 3.53e-25 Monocyte count; BRCA cis rs3820928 0.900 rs6754155 chr2:227784961 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -8.87 -0.33 7.05e-18 Pulmonary function; BRCA cis rs6558530 0.692 rs6558525 chr8:1702523 A/G cg19131313 chr8:1704013 NA -0.39 -7.82 -0.3 2.16e-14 Systolic blood pressure; BRCA cis rs7665147 1 rs7665147 chr4:57767327 T/A cg26694713 chr4:57773883 REST 0.5 10.07 0.37 3.21e-22 Platelet count; BRCA cis rs1878931 0.501 rs37800 chr16:3423648 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -11.84 -0.42 2.2e-29 Body mass index (adult); BRCA cis rs60843830 1.000 rs7566279 chr2:281178 C/G cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.37 0.49 8.53e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs17401966 0.931 rs34225619 chr1:10371987 C/T cg15208524 chr1:10270712 KIF1B 0.37 8.11 0.31 2.57e-15 Hepatocellular carcinoma; BRCA cis rs3820928 0.874 rs6740108 chr2:227889559 G/T cg11843606 chr2:227700838 RHBDD1 0.35 7.81 0.3 2.4e-14 Pulmonary function; BRCA cis rs68170813 0.559 rs74387778 chr7:106963213 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.47 -0.32 1.7e-16 Coronary artery disease; BRCA cis rs11758351 0.660 rs11757754 chr6:26219744 A/C cg01420254 chr6:26195488 NA 0.57 8.81 0.33 1.15e-17 Gout;Renal underexcretion gout; BRCA cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg13119609 chr19:45449297 APOC2 0.48 13.24 0.46 1.5e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs17384381 1.000 rs12140935 chr1:85855716 G/A cg16011679 chr1:85725395 C1orf52 0.53 8.18 0.31 1.56e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6594713 0.570 rs35926701 chr5:112898969 A/G cg12552261 chr5:112820674 MCC 0.5 7.91 0.3 1.13e-14 Brain cytoarchitecture; BRCA trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg03929089 chr4:120376271 NA -0.43 -8.02 -0.3 5.16e-15 Acute lymphoblastic leukemia (childhood); BRCA trans rs11098499 0.954 rs3733519 chr4:120423448 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.03 0.3 4.79e-15 Corneal astigmatism; BRCA cis rs796364 0.806 rs10931890 chr2:201102055 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.63 -9.1 -0.34 1.11e-18 Schizophrenia; BRCA cis rs752010 0.545 rs6600379 chr1:42053497 T/C cg06885757 chr1:42089581 HIVEP3 0.22 8.0 0.3 6.07e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6912958 0.754 rs4587143 chr6:88292291 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -8.75 -0.33 1.94e-17 Monocyte percentage of white cells; BRCA cis rs7953508 0.506 rs10777530 chr12:93961110 C/T cg18151635 chr12:93972918 NA -0.46 -9.12 -0.34 9.46e-19 Pubertal anthropometrics; BRCA cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg24838063 chr12:130822603 PIWIL1 0.68 16.73 0.55 2.13e-52 Menopause (age at onset); BRCA cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg11663144 chr21:46675770 NA -0.47 -9.54 -0.35 2.88e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11098499 0.562 rs2389879 chr4:120557684 G/A cg09307838 chr4:120376055 NA -0.53 -11.23 -0.41 7.88e-27 Corneal astigmatism; BRCA cis rs9309711 0.560 rs6548164 chr2:3472665 C/T cg15506890 chr2:3487001 NA 0.47 10.07 0.37 3.21e-22 Neurofibrillary tangles; BRCA cis rs2762353 0.935 rs1183200 chr6:25818646 G/C cg03517284 chr6:25882590 NA -0.47 -10.66 -0.39 1.57e-24 Blood metabolite levels; BRCA trans rs2727020 0.617 rs7102702 chr11:49401125 T/G cg03929089 chr4:120376271 NA -0.74 -16.12 -0.54 2.68e-49 Coronary artery disease; BRCA cis rs739496 0.542 rs10219736 chr12:111788402 C/T cg10833066 chr12:111807467 FAM109A 0.34 8.11 0.31 2.52e-15 Platelet count; BRCA cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg01483505 chr11:975446 AP2A2 0.3 8.07 0.3 3.51e-15 Alzheimer's disease (late onset); BRCA cis rs7580658 0.545 rs13001184 chr2:127952206 A/G cg16751203 chr2:127950803 CYP27C1 0.28 8.19 0.31 1.44e-15 Protein C levels; BRCA cis rs7267979 1.000 rs4815404 chr20:25301845 T/G cg08601574 chr20:25228251 PYGB -0.34 -8.37 -0.31 3.55e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg11905131 chr22:24372483 LOC391322 0.45 8.9 0.33 5.51e-18 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs7560272 0.538 rs2001436 chr2:73928965 A/T cg20560298 chr2:73613845 ALMS1 0.35 9.0 0.34 2.64e-18 Schizophrenia; BRCA cis rs6860806 0.661 rs334902 chr5:131586559 C/G cg04518342 chr5:131593106 PDLIM4 0.38 9.56 0.35 2.46e-20 Breast cancer; BRCA cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.64 0.32 4.52e-17 Rheumatoid arthritis; BRCA cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg08392591 chr16:89556376 ANKRD11 -0.48 -12.02 -0.43 3.87e-30 Multiple myeloma (IgH translocation); BRCA cis rs9291683 0.588 rs12647117 chr4:10022059 T/C cg02734326 chr4:10020555 SLC2A9 0.4 8.72 0.33 2.41e-17 Bone mineral density; BRCA cis rs796364 0.760 rs55906940 chr2:201049386 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.07 -0.34 1.49e-18 Schizophrenia; BRCA cis rs72781680 0.898 rs72782117 chr2:24026921 G/A cg08917208 chr2:24149416 ATAD2B 1.05 14.36 0.49 9.8e-41 Lymphocyte counts; BRCA cis rs17270561 0.609 rs7770037 chr6:25760591 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg11822812 chr5:140052017 DND1 0.29 7.93 0.3 9.56e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs778371 0.723 rs12105766 chr2:233617647 A/G cg08000102 chr2:233561755 GIGYF2 0.82 19.07 0.6 1.55e-64 Schizophrenia; BRCA cis rs9914988 0.943 rs34693224 chr17:27079555 C/T cg20469991 chr17:27169893 C17orf63 -0.47 -9.28 -0.34 2.6e-19 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs870825 0.932 rs10034861 chr4:185577450 C/T cg04058563 chr4:185651563 MLF1IP 0.79 12.9 0.45 5.51e-34 Blood protein levels; BRCA cis rs4713118 0.911 rs2394000 chr6:27686991 A/G cg20933634 chr6:27740509 NA 0.42 8.2 0.31 1.34e-15 Parkinson's disease; BRCA cis rs13046373 0.535 rs9977510 chr21:32027920 A/G cg14062083 chr21:31802829 KRTAP13-4 0.33 8.85 0.33 8.46e-18 HDL cholesterol; BRCA cis rs3768617 0.966 rs10911253 chr1:183086190 T/C ch.1.3577855R chr1:183094577 LAMC1 0.46 10.37 0.38 2.24e-23 Fuchs's corneal dystrophy; BRCA trans rs3733585 0.605 rs4235355 chr4:10123078 C/A cg26043149 chr18:55253948 FECH -0.4 -8.47 -0.32 1.75e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6087990 0.806 rs4911257 chr20:31359574 T/C cg13636640 chr20:31349939 DNMT3B 0.6 18.32 0.59 1.44e-60 Ulcerative colitis; BRCA cis rs546131 1.000 rs546131 chr11:34851760 G/C cg06937548 chr11:34938143 PDHX;APIP 0.4 7.83 0.3 2.05e-14 Lung disease severity in cystic fibrosis; BRCA cis rs870825 0.616 rs2310108 chr4:185639475 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA cis rs7766436 0.614 rs12660581 chr6:22564435 C/T cg13666174 chr6:22585274 NA -0.41 -8.66 -0.32 3.86e-17 Coronary artery disease; BRCA cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg11608241 chr8:8085544 FLJ10661 0.28 8.1 0.31 2.86e-15 Mood instability; BRCA cis rs11229555 1.000 rs3168135 chr11:58386177 G/A cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg23887609 chr12:130822674 PIWIL1 0.43 9.33 0.35 1.71e-19 Menopause (age at onset); BRCA cis rs12586317 0.547 rs2383693 chr14:35500205 A/C cg16230307 chr14:35515116 FAM177A1 0.76 15.31 0.52 2.65e-45 Psoriasis; BRCA cis rs2153535 0.541 rs1414352 chr6:8485547 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.48 0.5 2.79e-41 Motion sickness; BRCA trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg00990874 chr7:1149470 C7orf50 -0.63 -13.23 -0.46 1.71e-35 Bronchopulmonary dysplasia; BRCA cis rs909674 0.541 rs5750812 chr22:39793079 G/A cg05872129 chr22:39784769 NA -0.57 -13.37 -0.47 4e-36 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs28374715 0.662 rs16971558 chr15:41458619 G/A cg18705301 chr15:41695430 NDUFAF1 -0.77 -15.67 -0.53 4.54e-47 Ulcerative colitis; BRCA cis rs7737355 0.947 rs3776030 chr5:130776738 A/G cg06307176 chr5:131281290 NA -0.55 -10.99 -0.4 7.78e-26 Life satisfaction; BRCA cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.67 -0.32 3.58e-17 Intelligence (multi-trait analysis); BRCA cis rs7100689 0.622 rs1340383 chr10:82095968 T/G cg01528321 chr10:82214614 TSPAN14 0.82 17.42 0.57 6.76e-56 Post bronchodilator FEV1; BRCA trans rs8062405 0.721 rs151181 chr16:28490517 A/G cg09719594 chr16:21412588 NA -0.36 -8.52 -0.32 1.12e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.5 -11.38 -0.41 1.97e-27 Colorectal cancer; BRCA cis rs9467773 0.620 rs2494716 chr6:26662736 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.42e-42 Intelligence (multi-trait analysis); BRCA cis rs274567 0.550 rs272885 chr5:131667736 A/G cg12564285 chr5:131593104 PDLIM4 0.35 8.0 0.3 5.92e-15 Blood metabolite levels; BRCA cis rs3768617 0.510 rs7518957 chr1:183093028 A/T ch.1.3577855R chr1:183094577 LAMC1 -0.66 -17.75 -0.57 1.3e-57 Fuchs's corneal dystrophy; BRCA cis rs7177699 0.557 rs4380028 chr15:79111093 C/T cg00540400 chr15:79124168 NA -0.28 -7.91 -0.3 1.12e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs561341 1.000 rs55736640 chr17:30333848 G/A cg23018236 chr17:30244563 NA -0.66 -10.06 -0.37 3.49e-22 Hip circumference adjusted for BMI; BRCA cis rs11051970 0.614 rs2728684 chr12:32575665 C/A cg02745156 chr12:32552066 NA 0.27 8.28 0.31 6.98e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6964587 0.967 rs6970743 chr7:91744311 C/G cg01689657 chr7:91764605 CYP51A1 0.23 8.3 0.31 6.23e-16 Breast cancer; BRCA cis rs72781680 0.898 rs12623333 chr2:24111823 T/G cg08917208 chr2:24149416 ATAD2B 0.93 13.78 0.48 5.46e-38 Lymphocyte counts; BRCA cis rs1451375 0.698 rs1813214 chr7:50637525 A/G cg18232548 chr7:50535776 DDC 0.4 9.26 0.34 3.07e-19 Malaria; BRCA cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg11279151 chr3:101281821 RG9MTD1 0.5 9.41 0.35 9e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs11577318 0.853 rs7537477 chr1:26618829 C/T cg04990556 chr1:26633338 UBXN11 -0.48 -9.6 -0.36 1.77e-20 Granulocyte percentage of myeloid white cells; BRCA cis rs2645694 0.626 rs2703129 chr4:77818548 T/C cg18351406 chr4:77819688 ANKRD56 0.56 12.35 0.44 1.48e-31 Emphysema distribution in smoking; BRCA cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg00531865 chr16:30841666 NA -0.38 -9.13 -0.34 8.86e-19 Dementia with Lewy bodies; BRCA cis rs6570726 0.764 rs376257 chr6:145862949 G/A cg13319975 chr6:146136371 FBXO30 -0.4 -9.12 -0.34 1e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs9399137 0.507 rs6940878 chr6:135366309 G/A cg22676075 chr6:135203613 NA 0.47 9.07 0.34 1.44e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.28e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs11088226 0.581 rs2236430 chr21:33973408 A/G cg09050820 chr6:167586206 TCP10L2 -0.56 -11.21 -0.41 9.31e-27 Gastritis; BRCA cis rs9393777 0.513 rs9368447 chr6:26646674 A/C cg12292205 chr6:26970375 C6orf41 -0.47 -7.97 -0.3 7.21e-15 Intelligence (multi-trait analysis); BRCA cis rs4302748 0.862 rs12533280 chr7:36171953 C/T cg24442661 chr7:36192818 EEPD1 0.43 8.13 0.31 2.29e-15 Platelet count; BRCA cis rs6088590 1.000 rs3787222 chr20:33333040 T/A cg06115741 chr20:33292138 TP53INP2 0.51 11.44 0.41 1.11e-27 Coronary artery disease; BRCA trans rs1941687 0.563 rs9953034 chr18:31335294 A/G cg15819921 chr19:927150 ARID3A -0.44 -8.48 -0.32 1.56e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7560272 0.501 rs12713790 chr2:73945611 C/T cg20560298 chr2:73613845 ALMS1 0.33 8.4 0.32 2.84e-16 Schizophrenia; BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg14820908 chr5:178986412 RUFY1 0.44 11.2 0.4 1.07e-26 Lung cancer; BRCA cis rs2992756 1.000 rs2992756 chr1:18807339 T/C cg20200200 chr1:18807388 KLHDC7A -0.45 -11.37 -0.41 2.02e-27 Breast cancer; BRCA cis rs992157 0.798 rs4996257 chr2:219162836 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.53 11.89 0.43 1.4e-29 Colorectal cancer; BRCA cis rs2288073 0.930 rs7604097 chr2:24401805 G/C cg26838691 chr2:24397539 C2orf84 -0.48 -8.64 -0.32 4.35e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7766436 0.767 rs6456497 chr6:22603559 G/A cg13666174 chr6:22585274 NA -0.36 -9.42 -0.35 8.31e-20 Coronary artery disease; BRCA cis rs919433 0.929 rs10931779 chr2:198166825 A/G cg10820045 chr2:198174542 NA -0.4 -9.66 -0.36 1.1e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.91 -0.33 5.22e-18 Alzheimer's disease (late onset); BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.16 0.31 1.77e-15 Tonsillectomy; BRCA cis rs4363385 0.818 rs472076 chr1:153013742 G/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.54 -0.32 9.7e-17 Inflammatory skin disease; BRCA cis rs7301826 0.651 rs7956851 chr12:131319099 C/T cg11011512 chr12:131303247 STX2 0.48 12.34 0.44 1.52e-31 Plasma plasminogen activator levels; BRCA cis rs7707921 0.541 rs10066167 chr5:81495445 C/T cg15871215 chr5:81402204 ATG10 0.35 8.82 0.33 1.1e-17 Breast cancer; BRCA trans rs7824557 0.675 rs2736265 chr8:11186674 A/G cg15556689 chr8:8085844 FLJ10661 0.32 8.46 0.32 1.84e-16 Retinal vascular caliber; BRCA cis rs11098499 0.532 rs4833624 chr4:120585497 C/T cg09307838 chr4:120376055 NA 0.52 10.3 0.38 4.1000000000000003e-23 Corneal astigmatism; BRCA trans rs9291683 0.679 rs13137795 chr4:10051506 G/A cg26043149 chr18:55253948 FECH 0.47 9.94 0.37 9.37e-22 Bone mineral density; BRCA cis rs7918232 0.825 rs4749233 chr10:27467967 G/A cg14442939 chr10:27389572 ANKRD26 0.66 11.01 0.4 6.05e-26 Breast cancer; BRCA cis rs12579753 1.000 rs12830268 chr12:82233627 A/C cg07988820 chr12:82153109 PPFIA2 -0.64 -10.39 -0.38 1.86e-23 Resting heart rate; BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg27170947 chr2:26402098 FAM59B -0.66 -11.27 -0.41 5.17e-27 Gut microbiome composition (summer); BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.69 12.05 0.43 2.72e-30 Renal function-related traits (BUN); BRCA cis rs3733585 0.638 rs6414766 chr4:9956474 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.36 -0.38 2.44e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs877529 0.967 rs139385 chr22:39530132 C/A cg18708252 chr22:39545030 CBX7 -0.31 -7.9 -0.3 1.18e-14 Multiple myeloma; BRCA cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.83 -0.3 2.07e-14 Colorectal cancer; BRCA trans rs11098499 0.779 rs7699346 chr4:120310542 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.85 -0.3 1.79e-14 Corneal astigmatism; BRCA cis rs7267979 0.966 rs2482948 chr20:25296499 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.58 -0.32 7.04e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs16854884 0.770 rs951865 chr3:143812677 G/A cg06585982 chr3:143692056 C3orf58 0.42 8.1 0.31 2.88e-15 Economic and political preferences (feminism/equality); BRCA cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.44 9.88 0.36 1.55e-21 Aortic root size; BRCA cis rs9790314 0.846 rs6441371 chr3:161008727 C/A cg03342759 chr3:160939853 NMD3 -0.66 -14.31 -0.49 1.77e-40 Morning vs. evening chronotype; BRCA cis rs7633770 0.841 rs6442010 chr3:46669500 A/T cg11219411 chr3:46661640 NA 0.69 18.91 0.6 1.19e-63 Coronary artery disease; BRCA cis rs600806 0.778 rs2787015 chr1:110009434 A/C cg20591472 chr1:110008990 SYPL2 0.31 7.89 0.3 1.31e-14 Intelligence (multi-trait analysis); BRCA trans rs1268083 0.546 rs9398785 chr6:126057748 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.5 -11.71 -0.42 8.2e-29 Migraine; BRCA trans rs11088226 0.598 rs79634586 chr21:33959363 A/G cg09050820 chr6:167586206 TCP10L2 0.85 14.35 0.49 1.1e-40 Gastritis; BRCA cis rs1401999 1.000 rs6802849 chr3:183698943 A/C cg20387954 chr3:183756860 HTR3D 0.45 10.09 0.37 2.67e-22 Anterior chamber depth; BRCA cis rs7172677 0.737 rs8027604 chr15:75447773 C/T cg10253484 chr15:75165896 SCAMP2 -0.42 -8.04 -0.3 4.51e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.92 -0.43 1.06e-29 Bipolar disorder; BRCA cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.47 0.32 1.62e-16 Diabetic retinopathy; BRCA cis rs2425143 0.818 rs12481545 chr20:34407698 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -7.84 -0.3 1.85e-14 Blood protein levels; BRCA cis rs10845606 1.000 rs10845607 chr12:12835228 C/T cg09462578 chr12:12878428 APOLD1 -0.62 -11.13 -0.4 1.94e-26 Systemic lupus erythematosus; BRCA cis rs61931739 0.500 rs4436630 chr12:34394200 C/T cg06521331 chr12:34319734 NA -0.51 -10.12 -0.37 1.98e-22 Morning vs. evening chronotype; BRCA cis rs3740540 0.761 rs34042290 chr10:126286806 G/A cg04949429 chr10:126290192 LHPP -0.39 -8.27 -0.31 7.58e-16 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs738322 0.839 rs9607517 chr22:38596100 G/A cg25457927 chr22:38595422 NA 0.43 16.95 0.56 1.68e-53 Cutaneous nevi; BRCA cis rs990171 0.607 rs2192752 chr2:102769373 A/C cg22835712 chr2:102737379 NA -0.55 -9.57 -0.35 2.27e-20 Lymphocyte counts; BRCA cis rs7267979 0.903 rs6050481 chr20:25224580 C/T cg08601574 chr20:25228251 PYGB 0.39 9.45 0.35 6.06e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg04756594 chr16:24857601 SLC5A11 0.55 12.32 0.44 1.89e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg18904891 chr8:8559673 CLDN23 0.6 11.68 0.42 1.02e-28 Obesity-related traits; BRCA cis rs60871478 0.588 rs6952577 chr7:872100 C/T cg05535760 chr7:792225 HEATR2 0.72 11.7 0.42 8.51e-29 Cerebrospinal P-tau181p levels; BRCA cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg05283184 chr6:79620031 NA 0.43 11.15 0.4 1.61e-26 Intelligence (multi-trait analysis); BRCA cis rs1401999 1.000 rs6443926 chr3:183706630 A/C cg20387954 chr3:183756860 HTR3D 0.45 10.21 0.37 8.78e-23 Anterior chamber depth; BRCA cis rs17095355 1.000 rs11194917 chr10:111692552 C/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.76 -0.36 4.45e-21 Biliary atresia; BRCA cis rs6964587 0.869 rs10278155 chr7:91532456 T/G cg17063962 chr7:91808500 NA -0.51 -11.86 -0.42 1.89e-29 Breast cancer; BRCA cis rs9487051 0.676 rs13211313 chr6:109562074 G/C cg21918786 chr6:109611834 NA -0.32 -8.25 -0.31 9.15e-16 Reticulocyte fraction of red cells; BRCA trans rs9858542 0.903 rs9875617 chr3:49634696 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.76 -0.36 4.67e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs311392 0.966 rs425548 chr8:55087468 C/T cg11783602 chr8:55087084 NA -0.33 -9.59 -0.35 1.94e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg10802521 chr3:52805072 NEK4 0.31 8.4 0.32 2.87e-16 Electroencephalogram traits; BRCA cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11890956 chr21:40555474 PSMG1 -0.82 -19.71 -0.61 6.73e-68 Cognitive function; BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg19010396 chr19:19431384 KIAA0892;SF4 -0.45 -8.93 -0.33 4.44e-18 Tonsillectomy; BRCA cis rs514406 0.893 rs476108 chr1:53317351 C/T cg24675658 chr1:53192096 ZYG11B -0.51 -11.25 -0.41 6.58e-27 Monocyte count; BRCA cis rs17490626 0.568 rs12260685 chr10:71215799 C/T cg12610070 chr10:71211762 TSPAN15 -0.33 -11.48 -0.41 7.61e-28 Thrombosis; BRCA trans rs11098499 0.779 rs80242894 chr4:120375752 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.56 0.44 1.66e-32 Corneal astigmatism; BRCA cis rs79057730 0.599 rs4720893 chr7:804434 G/A cg11064039 chr7:766100 PRKAR1B;HEATR2 0.73 10.0 0.37 5.6e-22 Initial pursuit acceleration; BRCA cis rs6541297 0.793 rs6692319 chr1:230284375 C/T cg20703242 chr1:230279135 GALNT2 0.47 10.4 0.38 1.61e-23 Coronary artery disease; BRCA cis rs16958440 1.000 rs75800624 chr18:44633605 G/C cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs10751667 0.666 rs4072741 chr11:976565 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.46 0.55 5.3e-51 Alzheimer's disease (late onset); BRCA cis rs17253792 0.545 rs3742570 chr14:56016434 A/C cg01858014 chr14:56050164 KTN1 -0.61 -7.95 -0.3 8.3e-15 Putamen volume; BRCA cis rs9311474 0.713 rs352165 chr3:52242902 A/G cg15698299 chr3:52233019 ALAS1 -0.39 -9.25 -0.34 3.27e-19 Electroencephalogram traits; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.91 0.67 2.83e-85 Platelet count; BRCA cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg06026331 chr20:60912101 LAMA5 0.68 13.59 0.47 3.86e-37 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs939658 0.935 rs4778651 chr15:79447810 G/A cg17916960 chr15:79447300 NA -0.42 -10.15 -0.37 1.47e-22 Refractive error; BRCA cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.57 0.67 2.25e-83 Chronic sinus infection; BRCA cis rs6762477 0.748 rs34877766 chr3:50234126 A/G cg14019146 chr3:50243930 SLC38A3 -0.39 -9.32 -0.35 1.88e-19 Menarche (age at onset); BRCA cis rs13191362 0.810 rs28360533 chr6:162996742 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.17 0.31 1.67e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17401966 1.000 rs12734068 chr1:10376803 G/A cg03954927 chr1:10346856 KIF1B 0.45 12.84 0.45 9.75e-34 Hepatocellular carcinoma; BRCA cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg04166393 chr7:2884313 GNA12 0.41 8.66 0.32 3.9e-17 Height; BRCA cis rs59918340 0.764 rs10101692 chr8:142230823 C/T cg23750338 chr8:142222470 SLC45A4 0.53 12.77 0.45 1.94e-33 Immature fraction of reticulocytes; BRCA cis rs2760061 0.626 rs2527614 chr1:228126470 A/G cg02753203 chr1:228287806 NA -0.58 -12.34 -0.44 1.64e-31 Diastolic blood pressure; BRCA cis rs1577917 1.000 rs1857965 chr6:86630776 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.24e-29 Response to antipsychotic treatment; BRCA cis rs4285028 0.948 rs2877560 chr3:121699238 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.85 -0.39 2.68e-25 Multiple sclerosis; BRCA cis rs6121246 0.559 rs6119728 chr20:30413121 G/A cg13852791 chr20:30311386 BCL2L1 0.84 18.04 0.58 3.93e-59 Mean corpuscular hemoglobin; BRCA cis rs2153535 0.563 rs6942177 chr6:8534460 A/G cg21535247 chr6:8435926 SLC35B3 -0.41 -9.45 -0.35 6.14e-20 Motion sickness; BRCA cis rs4281086 0.541 rs10094938 chr8:10395326 A/C cg01072821 chr8:10382165 T-SP1 -0.29 -8.12 -0.31 2.39e-15 Obesity-related traits; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg04025307 chr7:1156635 C7orf50 0.72 17.73 0.57 1.64e-57 Longevity;Endometriosis; BRCA cis rs651907 0.557 rs7629753 chr3:101371922 C/T cg12386194 chr3:101231763 SENP7 -0.39 -8.37 -0.31 3.75e-16 Colorectal cancer; BRCA cis rs826838 1.000 rs11168217 chr12:38884278 T/C cg13010199 chr12:38710504 ALG10B 0.55 12.08 0.43 2.07e-30 Heart rate; BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 14.6 0.5 6.9e-42 Platelet count; BRCA cis rs7098414 0.511 rs7916349 chr10:82152638 G/A cg00277334 chr10:82204260 NA -0.48 -10.26 -0.38 5.96e-23 Post bronchodilator FEV1; BRCA cis rs965469 0.779 rs6051830 chr20:3373397 T/C cg25506879 chr20:3388711 C20orf194 -0.46 -9.06 -0.34 1.55e-18 IFN-related cytopenia; BRCA cis rs877282 0.583 rs11253425 chr10:815173 G/A cg15764593 chr10:829463 NA -0.61 -10.02 -0.37 4.78e-22 Uric acid levels; BRCA cis rs873946 0.586 rs3793686 chr10:134569559 A/G cg18305652 chr10:134549665 INPP5A 0.49 12.04 0.43 3.15e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2455601 0.608 rs11042104 chr11:8890924 C/G cg21881798 chr11:8931708 C11orf17;ST5 0.45 9.24 0.34 3.66e-19 Schizophrenia; BRCA cis rs12477438 0.798 rs1580068 chr2:99649969 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg11266682 chr4:10021025 SLC2A9 0.38 9.7 0.36 7.62e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg09165964 chr15:75287851 SCAMP5 -0.85 -20.27 -0.63 6.12e-71 Blood trace element (Zn levels); BRCA cis rs1707322 0.721 rs56255771 chr1:46224319 C/T cg03146154 chr1:46216737 IPP 0.46 10.2 0.37 1.01e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg05896524 chr21:47604654 C21orf56 0.51 10.46 0.38 9.19e-24 Testicular germ cell tumor; BRCA cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.38 0.76 1.05e-120 Cognitive function; BRCA cis rs11718455 0.767 rs13076333 chr3:43955070 G/A cg08738300 chr3:44038990 NA 0.5 8.69 0.33 2.95e-17 Coronary artery disease; BRCA cis rs9733 0.744 rs11204737 chr1:150847647 C/T cg13175981 chr1:150552382 MCL1 0.41 9.01 0.34 2.37e-18 Tonsillectomy; BRCA cis rs6028335 0.674 rs3752301 chr20:37654024 T/G cg16355469 chr20:37678765 NA 0.49 8.62 0.32 5.07e-17 Alcohol and nicotine co-dependence; BRCA cis rs7264396 0.563 rs2425119 chr20:34324216 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg04450456 chr4:17643702 FAM184B 0.39 11.62 0.42 1.95e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs700651 0.789 rs10497812 chr2:198911245 A/G cg00792783 chr2:198669748 PLCL1 -0.42 -9.06 -0.34 1.56e-18 Intracranial aneurysm; BRCA cis rs514406 0.526 rs835608 chr1:53169758 T/A cg08859206 chr1:53392774 SCP2 0.45 9.28 0.34 2.53e-19 Monocyte count; BRCA cis rs36051895 0.659 rs12348771 chr9:5083634 T/C cg02405213 chr9:5042618 JAK2 -0.55 -9.62 -0.36 1.52e-20 Pediatric autoimmune diseases; BRCA cis rs11252926 0.617 rs11253319 chr10:722732 C/T cg18196295 chr10:418757 DIP2C -0.39 -7.85 -0.3 1.71e-14 Psychosis in Alzheimer's disease; BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.13 0.31 2.23e-15 Tonsillectomy; BRCA cis rs9443645 0.901 rs9352686 chr6:79758223 T/G cg05283184 chr6:79620031 NA -0.42 -10.86 -0.39 2.46e-25 Intelligence (multi-trait analysis); BRCA cis rs600806 0.888 rs10858084 chr1:109882250 T/A cg20591472 chr1:110008990 SYPL2 0.32 8.14 0.31 2.05e-15 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg25036284 chr2:26402008 FAM59B 0.95 13.98 0.48 6.16e-39 Gut microbiome composition (summer); BRCA cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg23583168 chr7:148888333 NA -0.79 -18.48 -0.59 2.1e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13064411 0.696 rs6766615 chr3:113219342 T/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.53 -0.44 2.23e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg10556349 chr10:835070 NA 0.74 10.02 0.37 4.76e-22 Eosinophil percentage of granulocytes; BRCA cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 18.33 0.59 1.2e-60 Schizophrenia; BRCA cis rs10899021 0.512 rs2186955 chr11:74375475 C/T cg25880958 chr11:74394337 NA 0.4 8.51 0.32 1.26e-16 Response to metformin (IC50); BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg26314531 chr2:26401878 FAM59B -0.62 -10.91 -0.4 1.57e-25 Gut microbiome composition (summer); BRCA cis rs7582180 0.629 rs11678148 chr2:100966950 A/T cg14675211 chr2:100938903 LONRF2 0.52 11.56 0.42 3.33e-28 Intelligence (multi-trait analysis); BRCA cis rs514406 0.505 rs425520 chr1:53179805 C/G cg24675658 chr1:53192096 ZYG11B -0.65 -14.37 -0.49 8.77e-41 Monocyte count; BRCA cis rs208515 0.525 rs12193560 chr6:66690457 A/T cg07460842 chr6:66804631 NA 0.87 15.61 0.53 8.61e-47 Exhaled nitric oxide levels; BRCA cis rs6912958 0.754 rs1051131 chr6:88221546 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.55 -0.32 9.19e-17 Monocyte percentage of white cells; BRCA cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.93 21.02 0.64 5.49e-75 Smoking behavior; BRCA cis rs41005 0.597 rs62104919 chr2:8101999 C/T cg03155496 chr2:8117019 LOC339788 -0.5 -11.91 -0.43 1.13e-29 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs4481887 0.927 rs4307598 chr1:248474544 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs10463316 0.894 rs6579862 chr5:150761717 T/G cg03212797 chr5:150827313 SLC36A1 -0.4 -7.93 -0.3 1.01e-14 Metabolite levels (Pyroglutamine); BRCA cis rs35110281 0.627 rs1595167 chr21:44965874 T/G cg04455712 chr21:45112962 RRP1B 0.38 9.85 0.36 2.03e-21 Mean corpuscular volume; BRCA cis rs13046373 0.507 rs2832969 chr21:32019627 A/G cg24082983 chr21:31802169 KRTAP13-4 0.33 8.33 0.31 4.81e-16 HDL cholesterol; BRCA cis rs7615952 0.641 rs6438951 chr3:125696999 A/G cg04553112 chr3:125709451 NA -0.56 -8.57 -0.32 7.58e-17 Blood pressure (smoking interaction); BRCA cis rs911555 0.755 rs4906329 chr14:103942669 A/G cg12935359 chr14:103987150 CKB 0.64 14.72 0.5 1.86e-42 Intelligence (multi-trait analysis); BRCA cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg17330251 chr7:94953956 PON1 -0.42 -8.8 -0.33 1.27e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs3858526 0.834 rs10839169 chr11:6003190 C/G cg05234568 chr11:5960015 NA -0.46 -9.19 -0.34 5.61e-19 DNA methylation (variation); BRCA trans rs7618501 1.000 rs7618501 chr3:49772647 A/G cg21659725 chr3:3221576 CRBN -0.71 -21.59 -0.65 4.63e-78 Intelligence (multi-trait analysis); BRCA cis rs2806561 0.715 rs10753550 chr1:23322471 C/G cg19743168 chr1:23544995 NA -0.41 -9.82 -0.36 2.67e-21 Height; BRCA cis rs7666738 0.830 rs11932887 chr4:99072965 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.44 0.38 1.15e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10771431 1.000 rs10771431 chr12:9380859 C/T cg00504896 chr12:9437009 LOC642846 -0.45 -9.99 -0.37 6.13e-22 Breast size; BRCA cis rs812925 0.571 rs3087898 chr2:61765074 G/A cg15711740 chr2:61764176 XPO1 -0.42 -9.89 -0.36 1.46e-21 Immature fraction of reticulocytes; BRCA cis rs10870270 1.000 rs6560694 chr10:133773448 G/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.17 -0.49 7.4e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1595825 0.891 rs77029420 chr2:198651492 G/A cg19156104 chr2:198669113 PLCL1 -0.49 -8.43 -0.32 2.34e-16 Ulcerative colitis; BRCA cis rs8017423 0.630 rs4900038 chr14:90821677 A/G cg04374321 chr14:90722782 PSMC1 -0.49 -11.96 -0.43 6.75e-30 Mortality in heart failure; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.71 15.63 0.53 7.39e-47 Lymphocyte counts; BRCA cis rs7572263 0.724 rs6710543 chr2:209050447 G/A cg23998903 chr2:209048830 C2orf80 -0.42 -8.68 -0.32 3.16e-17 Glioma;Non-glioblastoma glioma; BRCA cis rs9527 0.590 rs2281877 chr10:104866062 C/T cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.4e-25 Arsenic metabolism; BRCA cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg00101154 chr16:420108 MRPL28 -0.58 -11.67 -0.42 1.22e-28 Bone mineral density (spine);Bone mineral density; BRCA trans rs9951602 0.512 rs1599636 chr18:76643916 G/A cg02800362 chr5:177631904 HNRNPAB 0.75 17.49 0.57 2.96e-56 Obesity-related traits; BRCA cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg20476274 chr7:133979776 SLC35B4 0.65 19.57 0.61 3.71e-67 Mean platelet volume; BRCA cis rs1059312 0.771 rs11059922 chr12:129290418 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.78 -19.62 -0.61 1.91e-67 Systemic lupus erythematosus; BRCA cis rs600806 0.778 rs2115787 chr1:110003840 T/G cg20591472 chr1:110008990 SYPL2 0.31 7.88 0.3 1.42e-14 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs7608498 chr2:10738428 G/A cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg11764359 chr7:65958608 NA -0.73 -15.99 -0.53 1.18e-48 Aortic root size; BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 21.28 0.64 2.17e-76 Platelet count; BRCA cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg05347473 chr6:146136440 FBXO30 -0.39 -7.87 -0.3 1.57e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1451375 0.698 rs56766899 chr7:50648938 T/C cg18232548 chr7:50535776 DDC 0.39 9.19 0.34 5.5e-19 Malaria; BRCA cis rs1580019 0.547 rs56981934 chr7:32535202 C/G cg06627557 chr7:32535165 LSM5;AVL9 1.13 34.93 0.81 2.54e-150 Cognitive ability; BRCA trans rs9929218 0.953 rs11075696 chr16:68731365 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.84 -17.64 -0.57 5.01e-57 Colorectal cancer; BRCA cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg10057126 chr4:77819792 ANKRD56 0.66 15.36 0.52 1.46e-45 Emphysema distribution in smoking; BRCA cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg05313129 chr8:58192883 C8orf71 -0.4 -8.33 -0.31 4.96e-16 Developmental language disorder (linguistic errors); BRCA cis rs8062405 0.755 rs12445823 chr16:28588049 A/C cg16576597 chr16:28551801 NUPR1 0.35 9.46 0.35 5.9e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11098499 0.908 rs28559989 chr4:120386627 C/T cg09307838 chr4:120376055 NA 0.75 16.06 0.54 5.37e-49 Corneal astigmatism; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg18016565 chr1:150552671 MCL1 -0.37 -8.52 -0.32 1.15e-16 Blood protein levels; BRCA cis rs2637030 0.586 rs1552649 chr5:52870476 A/T cg06476337 chr5:52856530 NDUFS4 0.35 7.91 0.3 1.15e-14 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs4566357 0.615 rs2396445 chr2:227917726 C/G cg05526886 chr2:227700861 RHBDD1 -0.4 -8.21 -0.31 1.2e-15 Coronary artery disease; BRCA cis rs7481584 0.624 rs421196 chr11:3048582 T/G cg08508325 chr11:3079039 CARS 0.28 8.49 0.32 1.5e-16 Calcium levels; BRCA cis rs9790314 0.687 rs62280331 chr3:160682092 C/A cg03342759 chr3:160939853 NMD3 0.45 8.62 0.32 5.14e-17 Morning vs. evening chronotype; BRCA trans rs61931739 0.500 rs6488215 chr12:34434803 A/T cg26384229 chr12:38710491 ALG10B 0.58 13.16 0.46 3.41e-35 Morning vs. evening chronotype; BRCA cis rs61990749 0.544 rs176962 chr14:78185510 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.62 9.6 0.36 1.75e-20 Fibroblast growth factor basic levels; BRCA cis rs1865721 0.839 rs59718187 chr18:73144032 C/T cg26385618 chr18:73139727 C18orf62 -0.43 -10.46 -0.38 9.32e-24 Intelligence; BRCA cis rs1868673 1.000 rs6770424 chr3:150174304 A/G cg04908077 chr3:150187338 NA -0.32 -8.6 -0.32 6.39e-17 Waist circumference; BRCA cis rs34172651 0.517 rs12927710 chr16:24790282 A/C cg06028605 chr16:24865363 SLC5A11 0.4 8.23 0.31 1.03e-15 Intelligence (multi-trait analysis); BRCA cis rs13118159 0.550 rs28522910 chr4:1374774 C/T cg02475777 chr4:1388615 CRIPAK 0.56 11.22 0.41 8.48e-27 Longevity; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00149659 chr3:10157352 C3orf10 0.79 13.62 0.47 2.94e-37 Alzheimer's disease; BRCA cis rs8114671 0.836 rs6142280 chr20:33622242 A/C cg24642439 chr20:33292090 TP53INP2 -0.41 -8.17 -0.31 1.63e-15 Height; BRCA cis rs4663866 0.901 rs34040298 chr2:239191607 T/C cg16914508 chr2:239161102 PER2 0.67 9.27 0.34 2.84e-19 Irritable bowel syndrome; BRCA cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg25237894 chr2:233734115 C2orf82 -0.41 -11.92 -0.43 9.93e-30 Coronary artery disease; BRCA cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg26384229 chr12:38710491 ALG10B 0.55 14.52 0.5 1.64e-41 Morning vs. evening chronotype; BRCA cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.38 -8.97 -0.33 3.19e-18 Platelet count; BRCA cis rs11758351 1.000 rs75921373 chr6:26191843 C/T cg01420254 chr6:26195488 NA 0.56 8.86 0.33 7.89e-18 Gout;Renal underexcretion gout; BRCA cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg09658497 chr7:2847517 GNA12 -0.41 -8.65 -0.32 4.17e-17 Height; BRCA cis rs73086581 1.000 rs17287486 chr20:3946267 T/C cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs10883723 0.810 rs61873733 chr10:104251458 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.8 0.62 2.24e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs738322 0.934 rs133016 chr22:38572582 C/T cg25457927 chr22:38595422 NA -0.32 -11.89 -0.43 1.39e-29 Cutaneous nevi; BRCA cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg02297831 chr4:17616191 MED28 0.38 8.47 0.32 1.62e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4727027 0.704 rs12535154 chr7:148895304 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 8.53 0.32 1.05e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg06494592 chr3:125709126 NA -0.52 -8.14 -0.31 2.08e-15 Blood pressure (smoking interaction); BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg03923535 chr7:1197113 ZFAND2A 0.41 8.47 0.32 1.62e-16 Longevity;Endometriosis; BRCA trans rs11098499 0.863 rs12498539 chr4:120468370 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs1451375 0.657 rs7802148 chr7:50648284 T/C cg18232548 chr7:50535776 DDC 0.39 9.19 0.34 5.5e-19 Malaria; BRCA trans rs7829975 0.806 rs2428 chr8:8641145 C/T cg16141378 chr3:129829833 LOC729375 -0.32 -8.41 -0.32 2.71e-16 Mood instability; BRCA cis rs514406 0.505 rs416968 chr1:53183513 A/G cg16325326 chr1:53192061 ZYG11B 0.82 22.22 0.66 1.71e-81 Monocyte count; BRCA cis rs2762353 0.935 rs1165196 chr6:25813150 A/G cg03517284 chr6:25882590 NA 0.47 10.68 0.39 1.36e-24 Blood metabolite levels; BRCA cis rs910316 0.699 rs175039 chr14:75468950 G/C cg08847533 chr14:75593920 NEK9 -0.81 -19.85 -0.62 1.11e-68 Height; BRCA cis rs4074536 0.536 rs10733096 chr1:116290280 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA trans rs116095464 0.558 rs9312979 chr5:222057 A/C cg00938859 chr5:1591904 SDHAP3 0.63 8.84 0.33 9.45e-18 Breast cancer; BRCA cis rs477692 0.544 rs12251589 chr10:131417354 C/A cg05714579 chr10:131428358 MGMT -0.78 -20.49 -0.63 4.01e-72 Response to temozolomide; BRCA cis rs7943191 0.810 rs7942154 chr11:62337163 G/A cg13298116 chr11:62369859 EML3;MTA2 0.57 11.42 0.41 1.23e-27 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs312273 0.693 rs1442192 chr12:41336447 A/G cg17827154 chr12:41323612 CNTN1 -0.39 -10.11 -0.37 2.11e-22 Bipolar disorder; BRCA cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs10046574 0.561 rs13438700 chr7:135207626 C/A cg27474649 chr7:135195673 CNOT4 0.65 10.84 0.39 2.91e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs709400 0.628 rs1989565 chr14:103862193 G/A cg12935359 chr14:103987150 CKB 0.55 13.32 0.47 6.69e-36 Body mass index; BRCA cis rs67460515 0.563 rs11720263 chr3:160848293 T/C cg17135325 chr3:160939158 NMD3 0.42 7.97 0.3 7.58e-15 Parkinson's disease; BRCA cis rs7945718 1.000 rs7945719 chr11:12748820 A/C cg25843174 chr11:12811716 TEAD1 0.23 8.52 0.32 1.19e-16 Educational attainment (years of education); BRCA cis rs796364 1.000 rs4263095 chr2:200830137 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.69 -11.55 -0.42 3.53e-28 Schizophrenia; BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18301423 chr5:131593218 PDLIM4 0.33 8.68 0.32 3.32e-17 Breast cancer; BRCA cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg22590775 chr19:49891494 CCDC155 0.49 8.68 0.32 3.4e-17 Multiple sclerosis; BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg14004847 chr7:1930337 MAD1L1 0.48 10.28 0.38 4.72e-23 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.790 rs2265474 chr6:146182092 G/A cg05347473 chr6:146136440 FBXO30 0.45 8.99 0.33 2.86e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg13798912 chr7:905769 UNC84A -0.49 -7.85 -0.3 1.7e-14 Cerebrospinal P-tau181p levels; BRCA cis rs17376456 0.569 rs11135397 chr5:93214975 G/T cg25358565 chr5:93447407 FAM172A 0.62 11.18 0.4 1.26e-26 Diabetic retinopathy; BRCA cis rs6121246 0.738 rs6121242 chr20:30410877 T/C cg13852791 chr20:30311386 BCL2L1 0.84 16.37 0.54 1.51e-50 Mean corpuscular hemoglobin; BRCA cis rs1712517 0.844 rs1163074 chr10:105021762 C/T cg05636881 chr10:105038444 INA 0.34 7.88 0.3 1.4e-14 Migraine; BRCA cis rs477895 0.653 rs12797120 chr11:63906819 C/T cg18225595 chr11:63971243 STIP1 0.51 9.39 0.35 1.01e-19 Mean platelet volume; BRCA cis rs4727027 0.645 rs12704072 chr7:148904888 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.39 8.09 0.3 3.01e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs796364 0.951 rs7565005 chr2:201013277 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.48 -8.66 -0.32 3.91e-17 Schizophrenia; BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg01262667 chr19:19385393 TM6SF2 0.41 10.74 0.39 7.82e-25 Tonsillectomy; BRCA cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs796364 0.806 rs203766 chr2:200902672 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -10.1 -0.37 2.41e-22 Schizophrenia; BRCA cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.21 0.46 2.22e-35 Bipolar disorder; BRCA cis rs9341808 0.718 rs2322630 chr6:80841033 A/G cg08355045 chr6:80787529 NA 0.38 9.55 0.35 2.61e-20 Sitting height ratio; BRCA cis rs796364 1.000 rs4410273 chr2:200818258 T/C cg23649088 chr2:200775458 C2orf69 0.57 8.22 0.31 1.13e-15 Schizophrenia; BRCA cis rs1577917 0.958 rs34994386 chr6:86524135 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.69 -0.42 1e-28 Response to antipsychotic treatment; BRCA cis rs977987 0.806 rs2903033 chr16:75389606 T/A cg03315344 chr16:75512273 CHST6 0.51 11.87 0.43 1.6800000000000001e-29 Dupuytren's disease; BRCA cis rs1448094 0.527 rs59445394 chr12:86237843 C/T cg02569458 chr12:86230093 RASSF9 0.32 7.87 0.3 1.5e-14 Major depressive disorder; BRCA cis rs877529 0.967 rs139410 chr22:39552597 A/G cg12193277 chr22:39547181 CBX7 0.47 12.88 0.45 6.39e-34 Multiple myeloma; BRCA cis rs17401966 0.931 rs4846213 chr1:10399178 A/G cg19773385 chr1:10388646 KIF1B -0.39 -8.51 -0.32 1.19e-16 Hepatocellular carcinoma; BRCA cis rs2712184 0.756 rs2541395 chr2:217647675 C/T cg05032264 chr2:217675019 NA -0.39 -9.34 -0.35 1.62e-19 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs4595586 0.545 rs12813151 chr12:39363405 C/G cg26384229 chr12:38710491 ALG10B -0.42 -9.26 -0.34 3.18e-19 Morning vs. evening chronotype; BRCA cis rs965469 0.895 rs6051844 chr20:3402674 G/T cg25506879 chr20:3388711 C20orf194 0.53 11.03 0.4 5.23e-26 IFN-related cytopenia; BRCA cis rs11696845 0.666 rs6103849 chr20:43365687 C/T cg25301532 chr20:43378953 KCNK15 -0.39 -9.1 -0.34 1.18e-18 Obesity-related traits; BRCA cis rs6964587 0.692 rs4729018 chr7:91644613 C/T cg17063962 chr7:91808500 NA 0.55 12.59 0.45 1.25e-32 Breast cancer; BRCA cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg05283184 chr6:79620031 NA -0.41 -10.33 -0.38 3.03e-23 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.900 rs2563287 chr5:140124786 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.4 -9.16 -0.34 7.04e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.93 0.37 1.03e-21 Tonsillectomy; BRCA cis rs9399135 0.935 rs11760000 chr6:135370496 G/A cg24558204 chr6:135376177 HBS1L 0.45 12.24 0.44 4.37e-31 Red blood cell count; BRCA trans rs9929218 1.000 rs2113200 chr16:68814948 A/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.68 -14.21 -0.49 5.03e-40 Colorectal cancer; BRCA trans rs4332037 0.707 rs62435130 chr7:1890002 C/T cg25206134 chr2:45395956 NA 0.53 8.84 0.33 9.05e-18 Bipolar disorder; BRCA cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg23711669 chr6:146136114 FBXO30 0.74 16.8 0.55 9.38e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg12310025 chr6:25882481 NA -0.42 -10.48 -0.38 7.77e-24 Height; BRCA cis rs11098499 0.865 rs4507344 chr4:120307485 C/A cg09307838 chr4:120376055 NA 0.73 16.01 0.53 9.75e-49 Corneal astigmatism; BRCA cis rs9443645 0.901 rs1538235 chr6:79689450 C/T cg11833968 chr6:79620685 NA -0.43 -9.65 -0.36 1.14e-20 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.79 -14.35 -0.49 1.1e-40 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3772130 0.962 rs11715951 chr3:121522968 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.84 0.39 2.87e-25 Cognitive performance; BRCA cis rs35306767 0.714 rs12783621 chr10:1083304 C/T cg26597838 chr10:835615 NA 0.6 10.39 0.38 1.87e-23 Eosinophil percentage of granulocytes; BRCA cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -7.94 -0.3 8.96e-15 Personality dimensions; BRCA trans rs4596713 0.508 rs7467352 chr9:71766081 G/A cg16512924 chr15:28394682 HERC2 0.44 10.41 0.38 1.53e-23 Headache; BRCA cis rs7246657 0.943 rs2081096 chr19:37964700 G/A cg14683738 chr19:37701593 ZNF585B 0.44 7.93 0.3 1e-14 Coronary artery calcification; BRCA cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg18305652 chr10:134549665 INPP5A 0.5 11.47 0.41 8.08e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg06238570 chr21:40685208 BRWD1 0.41 8.23 0.31 1.07e-15 Cognitive function; BRCA cis rs8030485 0.756 rs2102999 chr15:79410710 C/T cg17916960 chr15:79447300 NA -0.36 -8.33 -0.31 4.96e-16 Left ventricle wall thickness; BRCA trans rs17685 0.712 rs7794454 chr7:75776010 A/G cg19862616 chr7:65841803 NCRNA00174 -0.82 -26.79 -0.73 1.5e-106 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs17376456 1.000 rs34013242 chr5:93507947 C/T cg25358565 chr5:93447407 FAM172A 1.15 18.02 0.58 5.09e-59 Diabetic retinopathy; BRCA cis rs2354432 0.607 rs72692962 chr1:146802674 C/A cg25205988 chr1:146714368 CHD1L -0.91 -13.1 -0.46 6.75e-35 Mitochondrial DNA levels; BRCA cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -11.51 -0.41 5.51e-28 Glomerular filtration rate (creatinine); BRCA cis rs11955398 0.625 rs286154 chr5:59926911 C/T cg02684056 chr5:59996105 DEPDC1B 0.33 7.85 0.3 1.78e-14 Intelligence (multi-trait analysis); BRCA cis rs558133 1.000 rs558133 chr5:78425188 G/T cg25119155 chr5:78426943 BHMT 0.49 12.39 0.44 9.56e-32 Blood and toenail selenium levels; BRCA cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg05623727 chr3:50126028 RBM5 0.48 11.34 0.41 2.82e-27 Body mass index; BRCA cis rs17270561 0.697 rs9366633 chr6:25838054 A/G cg17691542 chr6:26056736 HIST1H1C 0.53 10.5 0.38 6.99e-24 Iron status biomarkers; BRCA cis rs17376456 1.000 rs13181660 chr5:93533658 A/G cg21475434 chr5:93447410 FAM172A 0.68 9.19 0.34 5.49e-19 Diabetic retinopathy; BRCA cis rs17253792 0.915 rs75296402 chr14:56182491 C/T cg01858014 chr14:56050164 KTN1 -0.69 -8.53 -0.32 1.07e-16 Putamen volume; BRCA cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg25208724 chr1:156163844 SLC25A44 1.03 32.52 0.79 1.27e-137 Testicular germ cell tumor; BRCA cis rs910316 0.664 rs2098252 chr14:75492732 T/C cg23033748 chr14:75592666 NEK9 0.34 8.02 0.3 5e-15 Height; BRCA cis rs9660992 0.710 rs1180721 chr1:205232696 T/C cg00857998 chr1:205179979 DSTYK 0.42 8.11 0.31 2.63e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs694739 1.000 rs11231757 chr11:64106317 C/T cg02228329 chr11:64053129 BAD;GPR137 0.48 10.23 0.38 7.34e-23 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs36051895 0.664 rs884132 chr9:5114522 G/A cg02405213 chr9:5042618 JAK2 -0.47 -8.65 -0.32 4.21e-17 Pediatric autoimmune diseases; BRCA cis rs11229555 0.598 rs11229426 chr11:58180063 T/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2239547 0.657 rs4687554 chr3:52864135 T/C cg18404041 chr3:52824283 ITIH1 -0.34 -9.09 -0.34 1.25e-18 Schizophrenia; BRCA cis rs7715811 1.000 rs2173980 chr5:13767116 A/T cg07548982 chr5:13769939 DNAH5 -0.41 -9.05 -0.34 1.75e-18 Subclinical atherosclerosis traits (other); BRCA cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7917772 0.502 rs10748827 chr10:104368336 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.52 0.59 1.22e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs78456975 1.000 rs13429866 chr2:1555211 C/A cg01028140 chr2:1542097 TPO -0.81 -16.01 -0.53 9.7e-49 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.56 -0.47 5.53e-37 Developmental language disorder (linguistic errors); BRCA cis rs826838 1.000 rs826888 chr12:39104719 C/G cg13010199 chr12:38710504 ALG10B -0.43 -9.97 -0.37 7.63e-22 Heart rate; BRCA cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.77 0.5 1.1e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1635 0.655 rs59598126 chr6:28303600 A/C cg15743358 chr6:28303923 ZNF323 -0.75 -8.56 -0.32 8.52e-17 Schizophrenia; BRCA cis rs7618915 0.547 rs4687636 chr3:52633929 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.0 0.4 6.75e-26 Bipolar disorder; BRCA cis rs1878931 0.501 rs28735976 chr16:3418419 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.59 12.07 0.43 2.26e-30 Body mass index (adult); BRCA cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg06636001 chr8:8085503 FLJ10661 0.61 14.04 0.49 3.05e-39 Mood instability; BRCA trans rs2562456 0.920 rs2650784 chr19:21666597 T/C cg25042112 chr7:64838748 ZNF92 0.42 8.35 0.31 4.13e-16 Pain; BRCA cis rs7089973 0.604 rs10885620 chr10:116630048 A/T cg23260525 chr10:116636907 FAM160B1 0.3 7.95 0.3 8.56e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs28595532 0.920 rs10001115 chr4:119781867 A/C cg21605333 chr4:119757512 SEC24D 1.34 14.02 0.48 4.03e-39 Cannabis dependence symptom count; BRCA cis rs11105298 0.891 rs3825330 chr12:89933710 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.85 -0.36 2.06e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs17685 0.753 rs1639609 chr7:75683581 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.96 -0.33 3.5e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg08219700 chr8:58056026 NA 0.45 8.16 0.31 1.77e-15 Developmental language disorder (linguistic errors); BRCA cis rs10752881 1.000 rs8179282 chr1:182974598 C/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.71 0.55 2.93e-52 Colorectal cancer; BRCA cis rs4363385 0.510 rs6689066 chr1:153045154 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -7.83 -0.3 2.11e-14 Inflammatory skin disease; BRCA cis rs28493229 0.708 rs4803352 chr19:41159193 C/T cg21869046 chr19:41225005 ITPKC -0.3 -8.79 -0.33 1.33e-17 Kawasaki disease; BRCA cis rs1538970 0.781 rs12049503 chr1:46021556 G/T cg05343316 chr1:45956843 TESK2 0.69 13.95 0.48 8.72e-39 Platelet count; BRCA cis rs1008375 1.000 rs6846238 chr4:17629939 A/G cg15017067 chr4:17643749 FAM184B 0.3 9.1 0.34 1.17e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg22974920 chr21:40686053 BRWD1 -0.4 -8.65 -0.32 4.15e-17 Cognitive function; BRCA cis rs6500602 0.893 rs6500601 chr16:4497199 G/C cg08645402 chr16:4508243 NA 0.4 8.53 0.32 1.03e-16 Schizophrenia; BRCA cis rs6547741 0.967 rs4665999 chr2:27834444 T/C cg27432699 chr2:27873401 GPN1 0.44 9.28 0.34 2.52e-19 Oral cavity cancer; BRCA cis rs61931739 0.517 rs7486246 chr12:34526419 T/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.3e-22 Morning vs. evening chronotype; BRCA cis rs4595586 0.545 rs6580896 chr12:39372223 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs13137808 chr4:99047095 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6910061 0.830 rs6456869 chr6:11115348 G/A cg27233058 chr6:11094804 LOC221710 0.5 8.51 0.32 1.21e-16 Diabetic kidney disease; BRCA cis rs17376456 0.877 rs10476599 chr5:93383423 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.48 0.32 1.51e-16 Diabetic retinopathy; BRCA trans rs6951245 0.554 rs78999139 chr7:1138525 G/A cg13565492 chr6:43139072 SRF -0.89 -16.02 -0.54 8.45e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg24812749 chr6:127587940 RNF146 0.75 16.7 0.55 3.14e-52 Breast cancer; BRCA cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg08999081 chr20:33150536 PIGU 0.44 12.51 0.44 2.96e-32 Glomerular filtration rate (creatinine); BRCA cis rs796364 0.715 rs11688872 chr2:201052418 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -8.93 -0.33 4.67e-18 Schizophrenia; BRCA cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg01884057 chr2:25150051 NA 0.34 9.22 0.34 4.21e-19 Body mass index; BRCA cis rs7072216 0.727 rs3750603 chr10:100175536 A/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.7 -0.36 7.5e-21 Metabolite levels; BRCA cis rs10046574 0.731 rs6961685 chr7:135115985 T/C cg27474649 chr7:135195673 CNOT4 0.61 8.62 0.32 5.25e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs561341 1.000 rs72825712 chr17:30316119 A/T cg23018236 chr17:30244563 NA -0.68 -10.71 -0.39 1.02e-24 Hip circumference adjusted for BMI; BRCA cis rs524281 0.814 rs10896098 chr11:65968416 G/A cg16950941 chr11:66035639 RAB1B -0.38 -8.03 -0.3 4.85e-15 Electroencephalogram traits; BRCA cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg24642439 chr20:33292090 TP53INP2 -0.41 -8.2 -0.31 1.31e-15 Height; BRCA cis rs7666738 1.000 rs13116475 chr4:99054843 C/T cg03676636 chr4:99064102 C4orf37 -0.23 -8.05 -0.3 4.13e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7904368 0.806 rs12242261 chr10:16872929 T/C cg14835575 chr10:16859367 RSU1 0.6 12.49 0.44 3.5e-32 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs10540 1.000 rs12418639 chr11:473300 A/C cg19913688 chr11:428466 ANO9 0.71 10.26 0.38 5.56e-23 Body mass index; BRCA cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg26587870 chr6:27730563 NA -0.71 -9.62 -0.36 1.5e-20 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs4285028 0.948 rs1920309 chr3:121665479 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.94 -0.4 1.2e-25 Multiple sclerosis; BRCA cis rs7786808 0.705 rs1377373 chr7:158215549 A/C cg09998033 chr7:158218633 PTPRN2 0.34 8.31 0.31 5.96e-16 Obesity-related traits; BRCA cis rs3733585 0.699 rs6449178 chr4:9968684 A/G cg00071950 chr4:10020882 SLC2A9 0.44 10.34 0.38 2.77e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs897984 0.542 rs8061047 chr16:31068960 T/C cg00531865 chr16:30841666 NA -0.36 -8.45 -0.32 2.03e-16 Dementia with Lewy bodies; BRCA cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg14196790 chr5:131705035 SLC22A5 0.42 10.24 0.38 6.61e-23 Breast cancer;Mosquito bite size; BRCA cis rs7959452 0.868 rs10784774 chr12:69737879 C/T cg20891283 chr12:69753455 YEATS4 -0.55 -13.41 -0.47 2.75e-36 Blood protein levels; BRCA cis rs887829 0.569 rs3821242 chr2:234637803 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.72 -0.33 2.41e-17 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs12824058 0.549 rs4759453 chr12:130824565 C/G cg24229701 chr12:130821962 PIWIL1 0.38 8.33 0.31 4.81e-16 Menopause (age at onset); BRCA cis rs17270561 0.609 rs9358879 chr6:25742918 C/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs17270561 0.609 rs4712959 chr6:25727057 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg26874164 chr19:58962979 ZNF324B 0.45 9.57 0.35 2.37e-20 Uric acid clearance; BRCA cis rs7598759 0.712 rs10933372 chr2:232332325 G/A cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.1e-14 Noise-induced hearing loss; BRCA trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -14.15 -0.49 1.01e-39 Extrinsic epigenetic age acceleration; BRCA cis rs13064411 0.627 rs9872168 chr3:113233132 A/C cg18753928 chr3:113234510 CCDC52 -0.58 -12.11 -0.43 1.62e-30 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs736408 0.716 rs2239550 chr3:52822509 G/C cg18404041 chr3:52824283 ITIH1 -0.5 -16.05 -0.54 5.8e-49 Bipolar disorder; BRCA cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg18904891 chr8:8559673 CLDN23 0.58 11.36 0.41 2.2e-27 Obesity-related traits; BRCA cis rs17270561 0.666 rs9356987 chr6:25739187 C/A cg17691542 chr6:26056736 HIST1H1C 0.46 8.79 0.33 1.4e-17 Iron status biomarkers; BRCA cis rs66731853 0.769 rs657624 chr1:20888348 C/T cg04087271 chr1:20915334 CDA -0.45 -9.51 -0.35 3.93e-20 Mean corpuscular volume; BRCA cis rs34375054 0.558 rs12578774 chr12:125681761 A/G cg25124228 chr12:125621409 AACS 0.44 8.88 0.33 6.71e-18 Post bronchodilator FEV1/FVC ratio; BRCA cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg16850897 chr7:100343110 ZAN 0.38 8.56 0.32 8.64e-17 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA trans rs60843830 1.000 rs2290911 chr2:224919 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 14.82 0.51 6.39e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg23711669 chr6:146136114 FBXO30 0.7 16.2 0.54 9.95e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs10267417 0.603 rs10241914 chr7:19932429 C/T cg05791153 chr7:19748676 TWISTNB 0.43 8.09 0.3 3.01e-15 Night sleep phenotypes; BRCA cis rs754466 0.580 rs11002289 chr10:79532580 G/A cg17075019 chr10:79541650 NA -0.83 -20.3 -0.63 4.5e-71 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2302729 0.545 rs10161275 chr12:2771018 A/G cg19945202 chr12:2788847 CACNA1C -0.44 -10.02 -0.37 4.87e-22 Sleep quality; BRCA cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.5 -0.32 1.34e-16 Monocyte percentage of white cells; BRCA cis rs2243480 0.901 rs35823062 chr7:65965821 A/G cg18252515 chr7:66147081 NA -1.07 -15.92 -0.53 2.69e-48 Diabetic kidney disease; BRCA cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg04455712 chr21:45112962 RRP1B 0.41 10.57 0.39 3.56e-24 Mean corpuscular volume; BRCA cis rs11792861 0.926 rs7046725 chr9:111882729 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 8.45 0.32 1.93e-16 Menarche (age at onset); BRCA cis rs11098499 0.789 rs12498994 chr4:120250818 A/C cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs4948102 0.667 rs7811270 chr7:56139990 A/G cg09872392 chr7:56161020 PHKG1 -0.51 -12.71 -0.45 3.54e-33 Plasma homocysteine levels (post-methionine load test); BRCA cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.6e-29 Bipolar disorder; BRCA cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg03146154 chr1:46216737 IPP 0.53 11.78 0.42 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6580649 0.941 rs1635529 chr12:48395102 T/G cg05342945 chr12:48394962 COL2A1 -0.53 -10.43 -0.38 1.31e-23 Lung cancer; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg18538332 chr22:24372958 LOC391322 -0.41 -9.73 -0.36 6.09e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs13418410 0.539 rs11677468 chr2:33839053 T/C cg04131969 chr2:33951647 MYADML -0.5 -10.16 -0.37 1.35e-22 Non-response to antidepressants and depression; BRCA cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg21518248 chr2:162101506 NA -0.47 -9.05 -0.34 1.71e-18 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); BRCA cis rs7727544 0.716 rs3844312 chr5:131582356 C/T cg14196790 chr5:131705035 SLC22A5 0.44 11.34 0.41 2.77e-27 Blood metabolite levels; BRCA cis rs17384381 0.953 rs3768223 chr1:85809183 T/C cg16011679 chr1:85725395 C1orf52 0.52 7.94 0.3 8.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7607369 0.719 rs12613545 chr2:219623504 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 3.87e-26 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs8180040 0.966 rs6792461 chr3:47473168 C/T cg27129171 chr3:47204927 SETD2 -0.68 -15.92 -0.53 2.7e-48 Colorectal cancer; BRCA cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg20891283 chr12:69753455 YEATS4 0.7 19.14 0.6 7.06e-65 Blood protein levels; BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 13.4 0.47 2.76e-36 Platelet count; BRCA cis rs2235642 0.685 rs2667681 chr16:1653206 C/T cg09065629 chr16:1709722 CRAMP1L 0.35 8.02 0.3 5.16e-15 Coronary artery disease; BRCA cis rs10751667 0.666 rs7394992 chr11:980690 G/C cg01483505 chr11:975446 AP2A2 0.34 9.12 0.34 9.66e-19 Alzheimer's disease (late onset); BRCA cis rs1580019 0.961 rs4320456 chr7:32496003 T/C cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.48 0.32 1.51e-16 Cognitive ability; BRCA cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg15428835 chr7:75027521 TRIM73;TRIM74 -0.31 -8.21 -0.31 1.25e-15 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs600231 0.542 rs11227196 chr11:65234922 G/A cg01292856 chr11:65242576 NA 0.66 14.89 0.51 2.96e-43 Bone mineral density; BRCA cis rs8141529 0.956 rs469989 chr22:29303595 G/C cg02153584 chr22:29168773 CCDC117 -0.5 -10.22 -0.37 8.2000000000000006e-23 Lymphocyte counts; BRCA cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24110177 chr3:50126178 RBM5 -0.35 -9.44 -0.35 6.9e-20 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.78 20.91 0.64 2.19e-74 Chronic sinus infection; BRCA trans rs12310956 0.532 rs11052933 chr12:33969881 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.32 0.35 1.82e-19 Morning vs. evening chronotype; BRCA cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -11.44 -0.41 1.07e-27 Monocyte count; BRCA trans rs7786808 0.705 rs1377373 chr7:158215549 A/C cg02030672 chr11:45687055 CHST1 -0.43 -9.49 -0.35 4.35e-20 Obesity-related traits; BRCA cis rs992157 0.965 rs13427681 chr2:219167563 G/C cg00012203 chr2:219082015 ARPC2 0.6 12.39 0.44 9.4e-32 Colorectal cancer; BRCA cis rs4595586 0.545 rs7307303 chr12:39368976 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA trans rs9650657 0.645 rs4841409 chr8:10516374 C/T cg08975724 chr8:8085496 FLJ10661 0.43 8.6 0.32 6.33e-17 Neuroticism; BRCA cis rs10504229 0.639 rs56825757 chr8:58106469 A/G cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.931 rs11125885 chr2:61755728 G/C cg15711740 chr2:61764176 XPO1 -0.55 -14.14 -0.49 1.11e-39 Tuberculosis; BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 10.63 0.39 2.12e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs61931739 0.500 rs11513287 chr12:34584351 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.73 0.55 2.22e-52 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg15112475 chr7:1198522 ZFAND2A -0.38 -8.87 -0.33 7.4e-18 Longevity;Endometriosis; BRCA cis rs17253792 0.822 rs78826571 chr14:56048906 G/A cg01858014 chr14:56050164 KTN1 -0.73 -9.45 -0.35 6.29e-20 Putamen volume; BRCA trans rs9858542 1.000 rs4283605 chr3:49678651 A/G cg21659725 chr3:3221576 CRBN -0.49 -10.32 -0.38 3.47e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2011503 0.941 rs112253053 chr19:19425145 T/A cg15839431 chr19:19639596 YJEFN3 -0.4 -8.71 -0.33 2.56e-17 Bipolar disorder; BRCA cis rs4409675 0.576 rs10794507 chr1:28216072 T/C cg23691781 chr1:28212827 C1orf38 0.32 10.77 0.39 5.68e-25 Corneal astigmatism; BRCA cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.8 0.42 3.25e-29 Tonsillectomy; BRCA trans rs61931739 0.963 rs59195137 chr12:34091838 G/A cg26384229 chr12:38710491 ALG10B -0.4 -9.05 -0.34 1.66e-18 Morning vs. evening chronotype; BRCA cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.37 8.19 0.31 1.38e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs78456975 0.943 rs10470006 chr2:1580971 A/C cg26248373 chr2:1572462 NA -0.5 -10.18 -0.37 1.13e-22 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg13256891 chr4:100009986 ADH5 -0.47 -9.03 -0.34 1.93e-18 Alcohol dependence; BRCA cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg15017067 chr4:17643749 FAM184B 0.34 9.7 0.36 7.5e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs5756813 0.661 rs2285178 chr22:38205989 T/C cg19894588 chr14:64061835 NA -0.55 -11.55 -0.42 3.67e-28 Optic cup area;Vertical cup-disc ratio; BRCA trans rs11039798 0.588 rs7483361 chr11:48593786 G/A cg15704280 chr7:45808275 SEPT13 0.51 8.9 0.33 5.58e-18 Axial length; BRCA trans rs11098499 0.955 rs13129661 chr4:120152909 C/G cg25214090 chr10:38739885 LOC399744 0.5 10.65 0.39 1.68e-24 Corneal astigmatism; BRCA cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg11812906 chr14:75593930 NEK9 -0.69 -16.07 -0.54 4.73e-49 Height; BRCA cis rs6456156 0.819 rs9457273 chr6:167520749 A/T cg07741184 chr6:167504864 NA -0.29 -8.54 -0.32 9.84e-17 Primary biliary cholangitis; BRCA cis rs67460515 0.531 rs13060601 chr3:160823159 G/A cg03342759 chr3:160939853 NMD3 -0.7 -14.53 -0.5 1.52e-41 Parkinson's disease; BRCA cis rs35306767 0.714 rs7072554 chr10:1090988 C/T cg26597838 chr10:835615 NA 0.6 10.37 0.38 2.12e-23 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.568 rs377098 chr21:40535216 G/A cg17971929 chr21:40555470 PSMG1 -0.62 -14.4 -0.49 6.73e-41 Cognitive function; BRCA trans rs4596713 0.568 rs10114342 chr9:71746005 A/G cg16512924 chr15:28394682 HERC2 0.4 9.53 0.35 3.27e-20 Headache; BRCA cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg00149659 chr3:10157352 C3orf10 0.99 13.6 0.47 3.58e-37 Alzheimer's disease; BRCA cis rs2625529 0.652 rs2415128 chr15:72191073 T/C cg16672083 chr15:72433130 SENP8 0.7 16.89 0.56 3.26e-53 Red blood cell count; BRCA cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.97 -0.3 7.2e-15 Ulcerative colitis; BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg08470875 chr2:26401718 FAM59B -0.58 -9.2 -0.34 4.82e-19 Gut microbiome composition (summer); BRCA cis rs1577917 1.000 rs10455456 chr6:86670322 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.85 -0.42 2.07e-29 Response to antipsychotic treatment; BRCA cis rs10883723 0.810 rs2296588 chr10:104248087 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.72 0.62 5.57e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7772486 0.719 rs2206141 chr6:146086192 A/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.45 -0.32 1.92e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2425143 1.000 rs56116518 chr20:34286251 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.84 -0.33 9.09e-18 Blood protein levels; BRCA cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg22800045 chr5:56110881 MAP3K1 0.65 12.34 0.44 1.62e-31 Initial pursuit acceleration; BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg23708337 chr7:1209742 NA 0.51 8.43 0.32 2.28e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.56 8.88 0.33 6.58e-18 Renal function-related traits (BUN); BRCA cis rs7301826 0.651 rs4759517 chr12:131283698 G/A cg11011512 chr12:131303247 STX2 0.51 13.22 0.46 1.87e-35 Plasma plasminogen activator levels; BRCA cis rs13064411 0.627 rs9825827 chr3:113182231 T/C cg18753928 chr3:113234510 CCDC52 -0.54 -11.21 -0.41 9.33e-27 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs6977660 0.619 rs10263780 chr7:19778086 A/G cg05791153 chr7:19748676 TWISTNB -0.58 -11.27 -0.41 5.14e-27 Thyroid stimulating hormone; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 2e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs28493229 0.708 rs111410535 chr19:41158441 C/T cg21869046 chr19:41225005 ITPKC 0.32 9.17 0.34 6.31e-19 Kawasaki disease; BRCA trans rs12517041 0.935 rs16892409 chr5:23324350 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg22903471 chr2:27725779 GCKR -0.36 -8.61 -0.32 5.79e-17 Total body bone mineral density; BRCA cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs1325195 0.881 rs2816185 chr1:179117740 C/T cg11624085 chr17:8464688 MYH10 0.26 8.09 0.3 3.1e-15 IgE grass sensitization; BRCA cis rs4566357 0.557 rs6707158 chr2:227911269 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -9.48 -0.35 4.75e-20 Coronary artery disease; BRCA cis rs4664304 0.620 rs11895141 chr2:160716449 T/A cg18514922 chr2:160761262 LY75 0.33 7.89 0.3 1.29e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs35146811 0.735 rs2528900 chr7:99805319 A/G cg13334819 chr7:99746414 C7orf59 0.35 8.13 0.31 2.27e-15 Coronary artery disease; BRCA cis rs9487051 0.768 rs351752 chr6:109536034 C/A cg21918786 chr6:109611834 NA -0.34 -8.99 -0.34 2.7e-18 Reticulocyte fraction of red cells; BRCA cis rs6987853 0.787 rs2923448 chr8:42406008 G/A cg09913449 chr8:42400586 C8orf40 0.42 9.39 0.35 1.07e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg04972856 chr6:88032051 C6orf162;GJB7 -0.29 -8.02 -0.3 5.04e-15 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1865721 0.771 rs72975988 chr18:73128289 T/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.23 -0.37 7.83e-23 Intelligence; BRCA cis rs637571 0.565 rs633800 chr11:65638719 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.42 -8.19 -0.31 1.45e-15 Eosinophil percentage of white cells; BRCA cis rs9649465 0.967 rs1506642 chr7:123390058 A/G cg04330084 chr7:123175371 IQUB -0.32 -8.74 -0.33 2.02e-17 Migraine; BRCA cis rs895636 1.000 rs895636 chr2:45188353 A/G cg16198908 chr2:45192207 NA -0.43 -8.49 -0.32 1.42e-16 Metabolite levels;Fasting plasma glucose; BRCA cis rs7824557 0.670 rs2736381 chr8:11132766 A/T cg21775007 chr8:11205619 TDH -0.49 -9.93 -0.37 1.01e-21 Retinal vascular caliber; BRCA cis rs1003719 0.762 rs2835590 chr21:38463406 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs1577917 0.839 rs1447159 chr6:86609249 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.34 -8.97 -0.33 3.31e-18 Response to antipsychotic treatment; BRCA cis rs17270561 0.609 rs9358873 chr6:25731783 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 9.29 0.35 2.34e-19 Iron status biomarkers; BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 7.9 0.3 1.26e-14 Tonsillectomy; BRCA cis rs9650657 0.645 rs4841409 chr8:10516374 C/T cg27411982 chr8:10470053 RP1L1 0.37 8.39 0.31 3.15e-16 Neuroticism; BRCA trans rs11098499 0.954 rs6849561 chr4:120409694 C/G cg25214090 chr10:38739885 LOC399744 -0.54 -11.67 -0.42 1.15e-28 Corneal astigmatism; BRCA cis rs10924970 0.967 rs12731177 chr1:235463173 T/G cg26050004 chr1:235667680 B3GALNT2 0.35 8.6 0.32 5.95e-17 Asthma; BRCA cis rs7493 1.000 rs6961773 chr7:95037718 T/G cg19678392 chr7:94953810 PON1 -0.42 -8.82 -0.33 1.11e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs12762955 0.528 rs10903358 chr10:1102386 G/A cg20503657 chr10:835505 NA 0.89 13.51 0.47 9.13e-37 Response to angiotensin II receptor blocker therapy; BRCA cis rs67478160 0.679 rs8011109 chr14:104279974 G/A cg08213375 chr14:104286397 PPP1R13B 0.65 18.68 0.59 1.87e-62 Schizophrenia; BRCA cis rs35306767 0.903 rs12250936 chr10:870109 C/T cg26597838 chr10:835615 NA 1.01 17.83 0.58 5.39e-58 Eosinophil percentage of granulocytes; BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg00166722 chr3:10149974 C3orf24 0.67 13.44 0.47 1.83e-36 Alzheimer's disease; BRCA cis rs796364 0.715 rs77089299 chr2:201116853 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -8.34 -0.31 4.54e-16 Schizophrenia; BRCA cis rs941873 0.868 rs1483733 chr10:81130036 A/G cg11057378 chr10:81107060 PPIF 0.37 9.21 0.34 4.48e-19 Height; BRCA cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg22676075 chr6:135203613 NA -0.43 -8.45 -0.32 1.96e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7677751 0.806 rs4864857 chr4:55089814 T/C cg17187183 chr4:55093834 PDGFRA 0.45 8.88 0.33 6.85e-18 Corneal astigmatism; BRCA cis rs12701220 0.894 rs10257744 chr7:1045612 C/T cg02733842 chr7:1102375 C7orf50 -0.71 -12.35 -0.44 1.4e-31 Bronchopulmonary dysplasia; BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg00106254 chr7:1943704 MAD1L1 -0.42 -10.67 -0.39 1.46e-24 Bipolar disorder and schizophrenia; BRCA trans rs853679 0.599 rs149943 chr6:28002388 G/A cg01620082 chr3:125678407 NA -0.53 -8.0 -0.3 5.96e-15 Depression; BRCA cis rs4948102 0.767 rs4948096 chr7:56053118 C/T cg09872392 chr7:56161020 PHKG1 -0.4 -9.15 -0.34 7.4e-19 Plasma homocysteine levels (post-methionine load test); BRCA cis rs1707322 1.000 rs785465 chr1:46522577 G/T cg06784218 chr1:46089804 CCDC17 0.45 10.52 0.38 5.64e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 25.76 0.71 6.98e-101 Platelet count; BRCA trans rs12310956 0.532 rs11494810 chr12:33952881 C/A cg26384229 chr12:38710491 ALG10B 0.5 10.79 0.39 4.7e-25 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg11663144 chr21:46675770 NA -0.64 -15.38 -0.52 1.24e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg20503657 chr10:835505 NA 0.61 10.55 0.39 4.26e-24 Eosinophil percentage of granulocytes; BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.6 9.67 0.36 9.88e-21 Renal function-related traits (BUN); BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg08742575 chr21:47604166 C21orf56 0.4 8.09 0.3 2.98e-15 Testicular germ cell tumor; BRCA cis rs7666738 0.609 rs28833816 chr4:98868866 T/C cg05340658 chr4:99064831 C4orf37 0.55 10.7 0.39 1.04e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs13046373 0.535 rs9977510 chr21:32027920 A/G cg24082983 chr21:31802169 KRTAP13-4 0.33 8.09 0.3 3.12e-15 HDL cholesterol; BRCA cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs2882667 0.690 rs10463975 chr5:138263249 G/A cg04439458 chr5:138467593 SIL1 -0.36 -8.55 -0.32 8.77e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs6479891 1.000 rs12414796 chr10:65303087 G/A cg14819942 chr15:35414228 NA 0.35 8.44 0.32 2.16e-16 Arthritis (juvenile idiopathic); BRCA trans rs61931739 0.534 rs11053029 chr12:34131766 G/T cg26384229 chr12:38710491 ALG10B 0.66 13.92 0.48 1.2e-38 Morning vs. evening chronotype; BRCA cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.21 0.46 2.03e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9287719 0.967 rs6719701 chr2:10748283 G/A cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs4713118 0.662 rs149900 chr6:28014597 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.86 0.3 1.62e-14 Parkinson's disease; BRCA cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg11062466 chr8:58055876 NA 0.41 7.88 0.3 1.46e-14 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg21248554 chr2:27665150 KRTCAP3 -0.36 -9.16 -0.34 6.8e-19 Total body bone mineral density; BRCA cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg04450456 chr4:17643702 FAM184B 0.33 9.66 0.36 1.07e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4730250 0.554 rs17428504 chr7:106914944 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.1 -0.31 2.72e-15 Osteoarthritis; BRCA cis rs13064411 0.735 rs2614191 chr3:113269201 C/T cg18753928 chr3:113234510 CCDC52 -0.5 -10.21 -0.37 8.7e-23 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs9467160 0.651 rs9393557 chr6:24453195 C/G cg20631270 chr6:24437470 GPLD1 0.43 8.56 0.32 8.24e-17 Liver enzyme levels; BRCA cis rs1865760 1.000 rs3799372 chr6:25922311 A/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.46 0.38 9.53e-24 Height; BRCA cis rs7647973 0.626 rs12715437 chr3:49751856 T/C cg07636037 chr3:49044803 WDR6 0.5 8.24 0.31 9.95e-16 Menarche (age at onset); BRCA cis rs2289583 0.544 rs6495132 chr15:75255322 C/T cg14664628 chr15:75095509 CSK 0.39 8.73 0.33 2.2e-17 Systemic lupus erythematosus; BRCA cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg21644426 chr2:191273491 MFSD6 0.44 11.03 0.4 5.24e-26 Pulse pressure; BRCA cis rs7647973 0.580 rs2117938 chr3:49263850 A/G cg06212747 chr3:49208901 KLHDC8B -0.56 -11.99 -0.43 5.06e-30 Menarche (age at onset); BRCA cis rs875971 0.545 rs7811204 chr7:65852200 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 10.2 0.37 1.01e-22 Aortic root size; BRCA cis rs858239 0.600 rs7785842 chr7:23141706 T/A cg23682824 chr7:23144976 KLHL7 0.45 12.24 0.44 4.33e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs61990749 0.597 rs11623088 chr14:78137735 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.09 -0.37 2.67e-22 Fibroblast growth factor basic levels; BRCA cis rs2070488 0.965 rs9829192 chr3:38569463 G/T cg24069376 chr3:38537580 EXOG -0.42 -12.05 -0.43 2.72e-30 Electrocardiographic conduction measures; BRCA cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -8.5 -0.32 1.33e-16 Obesity-related traits; BRCA cis rs4319547 0.956 rs7397990 chr12:123119472 T/C cg23029597 chr12:123009494 RSRC2 -0.59 -12.44 -0.44 5.67e-32 Body mass index; BRCA cis rs735396 0.694 rs2264750 chr12:121450165 C/T cg02403541 chr12:121454288 C12orf43 0.64 12.05 0.43 2.96e-30 N-glycan levels; BRCA cis rs9487051 0.735 rs459956 chr6:109524760 A/G cg01475377 chr6:109611718 NA -0.44 -11.1 -0.4 2.62e-26 Reticulocyte fraction of red cells; BRCA trans rs7980799 0.682 rs10437795 chr12:33635336 C/G cg26384229 chr12:38710491 ALG10B -0.51 -10.79 -0.39 4.88e-25 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6912958 0.781 rs3934838 chr6:88284699 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs965469 1.000 rs6051709 chr20:3263685 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.2 -0.37 9.47e-23 IFN-related cytopenia; BRCA cis rs943466 1.000 rs6940353 chr6:33752550 G/A cg25922239 chr6:33757077 LEMD2 -0.38 -7.82 -0.3 2.19e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg02780029 chr10:43622663 RET 0.36 7.96 0.3 7.91e-15 Hirschsprung disease; BRCA cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg03433033 chr1:76189801 ACADM 0.89 23.77 0.69 5.4e-90 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs2736340 0.539 rs9644687 chr8:11323025 A/G cg06636001 chr8:8085503 FLJ10661 -0.44 -8.51 -0.32 1.28e-16 Systemic lupus erythematosus and Systemic sclerosis;Rheumatoid arthritis;Systemic lupus erythematosus;Kawasaki disease;Systemic lupus erythematosus or rheumatoid arthritis; BRCA cis rs2455799 0.573 rs2470546 chr3:15733897 T/C cg16303742 chr3:15540471 COLQ -0.38 -9.13 -0.34 8.98e-19 Mean platelet volume; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 20.35 0.63 2.32e-71 Platelet count; BRCA trans rs61931739 0.534 rs11052979 chr12:34035774 G/T cg26384229 chr12:38710491 ALG10B 0.68 14.34 0.49 1.23e-40 Morning vs. evening chronotype; BRCA cis rs7582180 0.629 rs12617779 chr2:100937707 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA cis rs79057730 0.528 rs4719313 chr7:822501 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.79 10.83 0.39 3.39e-25 Initial pursuit acceleration; BRCA cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.79 0.36 3.39e-21 Bipolar disorder; BRCA cis rs2204008 0.563 rs2320512 chr12:38266913 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.04 -0.37 4.08e-22 Bladder cancer; BRCA cis rs8077889 0.672 rs15359 chr17:41843979 C/G cg26893861 chr17:41843967 DUSP3 -1.06 -30.39 -0.77 3.64e-126 Triglycerides; BRCA cis rs896854 0.738 rs481887 chr8:95967838 A/G cg16049864 chr8:95962084 TP53INP1 0.48 10.7 0.39 1.13e-24 Type 2 diabetes; BRCA cis rs875971 0.545 rs313830 chr7:65551931 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.55 -10.45 -0.38 1.05e-23 Aortic root size; BRCA trans rs61931739 0.534 rs1490113 chr12:34132394 A/G cg13010199 chr12:38710504 ALG10B 0.48 9.26 0.34 3.1e-19 Morning vs. evening chronotype; BRCA cis rs2762353 0.574 rs9467574 chr6:25705718 C/G cg03264133 chr6:25882463 NA 0.7 15.98 0.53 1.32e-48 Blood metabolite levels; BRCA cis rs1153858 1.000 rs4627277 chr15:45652768 C/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.71 0.42 7.88e-29 Homoarginine levels; BRCA cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs12618769 0.597 rs3769740 chr2:99069208 A/G cg10123293 chr2:99228465 UNC50 -0.41 -8.36 -0.31 3.91e-16 Bipolar disorder; BRCA cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg11833968 chr6:79620685 NA -0.4 -8.77 -0.33 1.55e-17 Intelligence (multi-trait analysis); BRCA cis rs11083475 0.607 rs6508816 chr19:39267783 G/A cg07905965 chr19:39260460 NA 0.47 10.37 0.38 2.15e-23 Heart rate; BRCA cis rs9487051 0.621 rs830552 chr6:109549914 A/G cg01475377 chr6:109611718 NA -0.39 -7.84 -0.3 1.9e-14 Reticulocyte fraction of red cells; BRCA trans rs3858145 0.588 rs61854831 chr10:70035837 C/T cg04882175 chr6:131122610 NA -0.35 -8.35 -0.31 4.33e-16 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg13010199 chr12:38710504 ALG10B 0.42 9.03 0.34 2.05e-18 Morning vs. evening chronotype; BRCA cis rs11599315 0.507 rs12220555 chr10:1341858 C/T cg09624528 chr10:1369823 ADARB2 0.41 8.47 0.32 1.67e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg06115741 chr20:33292138 TP53INP2 -0.36 -7.9 -0.3 1.25e-14 Glomerular filtration rate (creatinine); BRCA cis rs17685 0.702 rs6960598 chr7:75772991 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 5.04e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg18270830 chr10:32634957 EPC1 0.56 9.72 0.36 6.35e-21 Sexual dysfunction (female); BRCA cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg17211192 chr8:82754475 SNX16 -0.58 -11.25 -0.41 6.3100000000000004e-27 Diastolic blood pressure; BRCA cis rs34779708 0.897 rs12830 chr10:35302705 C/T cg03585969 chr10:35415529 CREM 0.56 11.59 0.42 2.64e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs56114371 0.777 rs200483 chr6:27774824 C/T cg26587870 chr6:27730563 NA -0.49 -7.84 -0.3 1.94e-14 Breast cancer; BRCA cis rs7301826 0.610 rs4759789 chr12:131296380 A/C cg11011512 chr12:131303247 STX2 0.51 13.52 0.47 8.46e-37 Plasma plasminogen activator levels; BRCA trans rs61931739 0.500 rs11053218 chr12:34474792 A/C cg26384229 chr12:38710491 ALG10B -0.69 -14.91 -0.51 2.35e-43 Morning vs. evening chronotype; BRCA cis rs28830936 1.000 rs2577960 chr15:42028354 C/A cg17847044 chr15:42102381 MAPKBP1 0.33 9.38 0.35 1.15e-19 Diastolic blood pressure; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg22907277 chr7:1156413 C7orf50 0.46 10.55 0.39 4.08e-24 Longevity;Endometriosis; BRCA cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg14926445 chr8:58193284 C8orf71 -0.46 -8.76 -0.33 1.78e-17 Developmental language disorder (linguistic errors); BRCA cis rs1003719 0.788 rs2156076 chr21:38452634 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.25 0.49 3.12e-40 Eye color traits; BRCA cis rs68170813 0.559 rs75154004 chr7:106903326 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.48 -0.32 1.59e-16 Coronary artery disease; BRCA cis rs2016266 0.819 rs6580942 chr12:53662624 C/A cg26875137 chr12:53738046 NA 0.39 9.08 0.34 1.33e-18 Bone mineral density (spine);Bone mineral density; BRCA cis rs73086581 0.891 rs55871214 chr20:3965706 A/C cg02187196 chr20:3869020 PANK2 0.53 9.48 0.35 4.73e-20 Response to antidepressants in depression; BRCA cis rs7044106 0.791 rs2416797 chr9:123480600 C/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 12.68 0.45 5.22e-33 Hip circumference adjusted for BMI; BRCA cis rs1595825 0.891 rs111340803 chr2:198612877 A/G cg19156104 chr2:198669113 PLCL1 -0.41 -7.95 -0.3 8.41e-15 Ulcerative colitis; BRCA cis rs4853012 0.838 rs59570457 chr2:74344282 T/C cg19729930 chr2:74357872 NA 0.59 14.26 0.49 3.04e-40 Gestational age at birth (maternal effect); BRCA cis rs1878931 0.507 rs35214904 chr16:3410017 C/A cg02880119 chr16:3481970 NA 0.43 7.86 0.3 1.63e-14 Body mass index (adult); BRCA cis rs67460515 0.563 rs16831981 chr3:160897780 T/C cg17135325 chr3:160939158 NMD3 0.43 8.19 0.31 1.41e-15 Parkinson's disease; BRCA cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA trans rs4689592 0.503 rs4689064 chr4:7055603 A/G cg07817883 chr1:32538562 TMEM39B 0.52 8.53 0.32 1.03e-16 Monocyte percentage of white cells; BRCA cis rs3733585 0.638 rs13145554 chr4:9979589 C/T cg11266682 chr4:10021025 SLC2A9 0.36 9.38 0.35 1.16e-19 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg20573242 chr4:122745356 CCNA2 0.49 10.79 0.39 4.65e-25 Type 2 diabetes; BRCA cis rs7904368 0.754 rs11254231 chr10:16870246 A/G cg14835575 chr10:16859367 RSU1 0.59 11.97 0.43 6.23e-30 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 11.23 0.41 7.54e-27 Systemic lupus erythematosus; BRCA trans rs11098499 0.697 rs10016448 chr4:120298845 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs4889855 0.505 rs8076974 chr17:78621817 G/A cg16591659 chr17:78472290 NA -0.31 -7.88 -0.3 1.39e-14 Fractional excretion of uric acid; BRCA cis rs1829883 0.866 rs1523391 chr5:98794214 A/C cg08333243 chr5:99726346 NA -0.35 -8.03 -0.3 4.62e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs875971 0.502 rs6460311 chr7:66111873 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.56 -10.25 -0.38 6.09e-23 Aortic root size; BRCA cis rs7103648 1.000 rs10838705 chr11:47424931 G/A cg20307385 chr11:47447363 PSMC3 0.86 25.99 0.72 3.64e-102 Diastolic blood pressure;Systolic blood pressure; BRCA trans rs61931739 0.500 rs11053236 chr12:34507962 C/G cg26384229 chr12:38710491 ALG10B 0.75 16.69 0.55 3.62e-52 Morning vs. evening chronotype; BRCA cis rs9287719 0.901 rs4555317 chr2:10744247 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.8 17.42 0.57 6.31e-56 Smoking behavior; BRCA cis rs561341 1.000 rs757009 chr17:30243937 A/G cg13647721 chr17:30228624 UTP6 0.52 9.34 0.35 1.61e-19 Hip circumference adjusted for BMI; BRCA cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg25019033 chr10:957182 NA -0.41 -7.88 -0.3 1.41e-14 Eosinophil percentage of granulocytes; BRCA cis rs6089829 0.962 rs6089824 chr20:61659207 A/G cg08564027 chr20:61660810 NA 0.85 22.44 0.66 1.17e-82 Prostate cancer (SNP x SNP interaction); BRCA cis rs12541635 0.966 rs2132471 chr8:107000963 G/A cg10147462 chr8:107024639 NA 0.37 9.92 0.37 1.18e-21 Age of smoking initiation; BRCA cis rs875971 0.830 rs6967708 chr7:65657313 A/T cg11764359 chr7:65958608 NA -0.76 -17.43 -0.57 5.6e-56 Aortic root size; BRCA cis rs28374715 0.635 rs28557159 chr15:41657353 T/C cg18705301 chr15:41695430 NDUFAF1 -0.83 -19.57 -0.61 3.51e-67 Ulcerative colitis; BRCA cis rs8017423 0.967 rs2401875 chr14:90688451 A/G cg14092571 chr14:90743983 NA -0.34 -8.07 -0.3 3.4e-15 Mortality in heart failure; BRCA cis rs13136331 0.532 rs2615480 chr4:88577573 A/G cg22416721 chr4:88570574 DMP1 -0.59 -14.33 -0.49 1.43e-40 Sitting height ratio; BRCA cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg04553112 chr3:125709451 NA -0.54 -9.0 -0.34 2.48e-18 Blood pressure (smoking interaction); BRCA cis rs6665290 0.901 rs11580229 chr1:227210820 G/A cg10327440 chr1:227177885 CDC42BPA -1.09 -38.02 -0.83 3.29e-166 Myeloid white cell count; BRCA cis rs4713118 0.784 rs9468219 chr6:27731755 C/A cg08798685 chr6:27730294 NA -0.41 -8.03 -0.3 4.78e-15 Parkinson's disease; BRCA cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg17143192 chr8:8559678 CLDN23 0.57 11.12 0.4 2.3e-26 Obesity-related traits; BRCA cis rs807669 0.548 rs723414 chr22:19185736 G/A cg02655711 chr22:19163373 SLC25A1 0.65 16.03 0.54 7.32e-49 Metabolite levels; BRCA cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg08754478 chr10:133766260 PPP2R2D -0.68 -14.33 -0.49 1.34e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs6598955 0.627 rs3924324 chr1:26616280 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.35 -0.52 1.65e-45 Obesity-related traits; BRCA cis rs1790761 0.692 rs614080 chr11:67347287 G/A cg24690094 chr11:67383802 NA 0.49 10.57 0.39 3.53e-24 Mean corpuscular volume; BRCA trans rs11098499 0.908 rs12504149 chr4:120318577 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.01 0.3 5.51e-15 Corneal astigmatism; BRCA cis rs9399135 0.967 rs9376077 chr6:135299713 C/G cg24558204 chr6:135376177 HBS1L 0.44 12.22 0.44 5.3e-31 Red blood cell count; BRCA trans rs561341 1.000 rs497479 chr17:30328605 C/T cg20587970 chr11:113659929 NA -1.22 -22.1 -0.66 7.73e-81 Hip circumference adjusted for BMI; BRCA cis rs72781680 0.898 rs55841168 chr2:24007926 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs35306767 0.807 rs34885925 chr10:919032 G/C cg10556349 chr10:835070 NA 0.73 9.89 0.36 1.48e-21 Eosinophil percentage of granulocytes; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg08132940 chr7:1081526 C7orf50 -0.6 -8.74 -0.33 2.03e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs36051895 0.664 rs3780373 chr9:5098223 T/C cg02405213 chr9:5042618 JAK2 -0.5 -9.46 -0.35 5.73e-20 Pediatric autoimmune diseases; BRCA trans rs2204008 0.775 rs2387809 chr12:38363338 T/A cg06521331 chr12:34319734 NA -0.46 -8.52 -0.32 1.16e-16 Bladder cancer; BRCA cis rs6840360 0.571 rs718801 chr4:152549247 C/T cg22705602 chr4:152727874 NA -0.33 -8.13 -0.31 2.24e-15 Intelligence (multi-trait analysis); BRCA cis rs12357919 0.542 rs3740471 chr10:105363289 T/C cg00126946 chr10:105363258 SH3PXD2A 0.49 9.42 0.35 8.21e-20 White matter hyperintensity burden; BRCA cis rs5997397 0.967 rs5762777 chr22:29150044 T/C cg15103426 chr22:29168792 CCDC117 0.47 11.25 0.41 6.33e-27 Red cell distribution width; BRCA cis rs7264396 0.508 rs6060739 chr20:34567592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -12.3 -0.44 2.25e-31 Total cholesterol levels; BRCA cis rs7560272 0.695 rs10190002 chr2:73794054 C/T cg20560298 chr2:73613845 ALMS1 -0.42 -11.49 -0.41 6.32e-28 Schizophrenia; BRCA cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.65 0.5 4.09e-42 Personality dimensions; BRCA cis rs7267979 0.966 rs2261785 chr20:25262403 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.72 0.36 6.56e-21 Liver enzyme levels (alkaline phosphatase); BRCA trans rs11039798 0.557 rs4441015 chr11:49027070 A/G cg15704280 chr7:45808275 SEPT13 0.64 10.67 0.39 1.41e-24 Axial length; BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.1 0.34 1.14e-18 Tonsillectomy; BRCA cis rs1372520 0.567 rs2619349 chr4:90746646 G/T cg15133208 chr4:90757351 SNCA -0.38 -7.84 -0.3 1.85e-14 Neuroticism; BRCA cis rs2629540 0.855 rs12776722 chr10:126469833 G/A cg08799069 chr10:126477246 METTL10 0.56 11.02 0.4 5.75e-26 Cocaine dependence; BRCA cis rs11252926 0.598 rs4881256 chr10:453831 T/A cg16386425 chr10:429943 DIP2C -0.42 -9.06 -0.34 1.59e-18 Psychosis in Alzheimer's disease; BRCA cis rs1801251 1.000 rs283476 chr2:233650168 A/G cg08000102 chr2:233561755 GIGYF2 0.6 13.13 0.46 4.96e-35 Coronary artery disease; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg01874867 chr7:94954059 PON1 -0.5 -11.36 -0.41 2.34e-27 Paraoxonase activity; BRCA cis rs2153535 0.580 rs7745043 chr6:8513507 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.49 0.35 4.66e-20 Motion sickness; BRCA cis rs908922 0.676 rs1337340 chr1:152508260 T/C cg20991723 chr1:152506922 NA 0.38 8.67 0.32 3.47e-17 Hair morphology; BRCA cis rs13102973 0.899 rs13104662 chr4:135904615 C/T cg14419869 chr4:135874104 NA 0.46 9.16 0.34 7.08e-19 Subjective well-being; BRCA cis rs2992756 0.663 rs2992763 chr1:18804386 G/A cg14356550 chr1:18808102 KLHDC7A -0.39 -7.97 -0.3 7.36e-15 Breast cancer; BRCA cis rs2742234 0.554 rs1270015 chr10:43698240 G/T cg15436174 chr10:43711423 RASGEF1A 0.58 11.76 0.42 5e-29 Hirschsprung disease; BRCA cis rs9368481 0.729 rs9379948 chr6:26944783 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.21 0.31 1.25e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7666738 0.830 rs6854919 chr4:98947326 C/T cg05340658 chr4:99064831 C4orf37 0.66 16.18 0.54 1.39e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs724568 0.527 rs11126147 chr2:67934313 C/A cg17945962 chr2:67939740 NA -0.37 -9.76 -0.36 4.61e-21 Major depressive disorder (broad); BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg22903471 chr2:27725779 GCKR -0.39 -9.77 -0.36 4.3e-21 Total body bone mineral density; BRCA cis rs7095944 0.614 rs7099316 chr10:126469005 G/A cg08799069 chr10:126477246 METTL10 -0.4 -10.07 -0.37 3.04e-22 Asthma; BRCA cis rs9810890 0.850 rs73196995 chr3:128458070 G/A cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs8028182 0.636 rs7184046 chr15:75866150 G/C cg20655648 chr15:75932815 IMP3 0.46 8.99 0.33 2.87e-18 Sudden cardiac arrest; BRCA cis rs708547 0.647 rs781668 chr4:57825140 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.42 8.12 0.31 2.46e-15 Response to bleomycin (chromatid breaks); BRCA cis rs796364 0.951 rs12613687 chr2:200999256 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.89 -0.4 1.91e-25 Schizophrenia; BRCA cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg17971929 chr21:40555470 PSMG1 0.81 19.49 0.61 9.95e-67 Cognitive function; BRCA cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.57 13.09 0.46 7.21e-35 Personality dimensions; BRCA cis rs7666738 0.830 rs7662389 chr4:99019892 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.17 0.56 1.26e-54 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.909 rs10014719 chr4:120320715 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.01 0.3 5.51e-15 Corneal astigmatism; BRCA cis rs7618501 0.602 rs2624816 chr3:50117312 T/G cg24110177 chr3:50126178 RBM5 0.4 11.12 0.4 2.27e-26 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg05347473 chr6:146136440 FBXO30 -0.41 -7.95 -0.3 8.44e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10992471 0.603 rs7868013 chr9:95240173 G/A cg14631576 chr9:95140430 CENPP -0.38 -9.23 -0.34 3.97e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs4588572 0.643 rs1529499 chr5:77721431 T/C cg11547950 chr5:77652471 NA -0.47 -8.36 -0.31 4e-16 Triglycerides; BRCA cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg07606381 chr6:8435919 SLC35B3 0.66 14.7 0.5 2.41e-42 Motion sickness; BRCA trans rs2840044 1.000 rs10068 chr17:33901965 C/G cg19694781 chr19:47549865 TMEM160 0.45 10.67 0.39 1.47e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs8058578 1.000 rs13338946 chr16:30700858 T/C cg00531865 chr16:30841666 NA -0.5 -11.86 -0.42 1.76e-29 Multiple myeloma; BRCA cis rs1865760 0.566 rs2051544 chr6:26071093 C/T cg17691542 chr6:26056736 HIST1H1C 0.56 11.77 0.42 4.25e-29 Height; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg03188948 chr7:1209495 NA 0.83 11.3 0.41 4.03e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7552404 0.765 rs1251078 chr1:76189488 C/G cg10523679 chr1:76189770 ACADM -0.92 -26.53 -0.72 4.12e-105 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9399137 0.507 rs56164974 chr6:135288716 C/T cg24558204 chr6:135376177 HBS1L 0.59 15.88 0.53 4.35e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs896854 0.967 rs10808671 chr8:95967372 A/G cg26343298 chr8:95960752 TP53INP1 0.29 8.3 0.31 6.37e-16 Type 2 diabetes; BRCA trans rs9929218 0.953 rs28608872 chr16:68802038 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -14.01 -0.48 4.55e-39 Colorectal cancer; BRCA cis rs10256972 0.933 rs35696159 chr7:1047194 A/G cg04025307 chr7:1156635 C7orf50 0.43 9.72 0.36 6.53e-21 Longevity;Endometriosis; BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg11814155 chr7:99998594 ZCWPW1 0.44 8.32 0.31 5.27e-16 Platelet count; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg23358479 chr7:1110784 C7orf50 -0.49 -8.33 -0.31 4.8e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.69 14.68 0.5 2.83e-42 Lymphocyte counts; BRCA cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg15112475 chr7:1198522 ZFAND2A -0.37 -8.02 -0.3 4.91e-15 Longevity;Endometriosis; BRCA cis rs12618769 0.597 rs17033136 chr2:99149404 C/T cg10123293 chr2:99228465 UNC50 -0.42 -8.35 -0.31 4.37e-16 Bipolar disorder; BRCA cis rs2354432 0.556 rs72710311 chr1:146698256 A/G cg25205988 chr1:146714368 CHD1L -0.91 -11.4 -0.41 1.61e-27 Mitochondrial DNA levels; BRCA cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg17971929 chr21:40555470 PSMG1 0.79 18.81 0.6 3.73e-63 Cognitive function; BRCA cis rs4975616 0.804 rs459961 chr5:1337106 T/A cg07493874 chr5:1342172 CLPTM1L -0.51 -14.66 -0.5 3.66e-42 Lung cancer; BRCA cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg08859206 chr1:53392774 SCP2 -0.39 -8.08 -0.3 3.28e-15 Monocyte count; BRCA cis rs7131987 0.903 rs67517901 chr12:29421346 A/G cg09582351 chr12:29534625 ERGIC2 -0.48 -11.61 -0.42 2.16e-28 QT interval; BRCA cis rs16958440 0.867 rs74346439 chr18:44677467 G/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg11645453 chr3:52864694 ITIH4 0.45 10.56 0.39 3.82e-24 Schizophrenia; BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00166722 chr3:10149974 C3orf24 0.66 13.42 0.47 2.4e-36 Alzheimer's disease; BRCA cis rs11958404 0.932 rs72816566 chr5:157427613 G/A cg05962755 chr5:157440814 NA 0.51 9.93 0.37 1.04e-21 IgG glycosylation; BRCA cis rs7737355 0.947 rs6884741 chr5:130894613 A/G cg06307176 chr5:131281290 NA 0.52 10.06 0.37 3.4e-22 Life satisfaction; BRCA cis rs67478160 0.584 rs2295147 chr14:104195664 A/G cg08213375 chr14:104286397 PPP1R13B -0.5 -12.49 -0.44 3.44e-32 Schizophrenia; BRCA cis rs8180040 0.701 rs1079276 chr3:47045739 C/G cg02527881 chr3:46936655 PTH1R -0.38 -9.34 -0.35 1.59e-19 Colorectal cancer; BRCA cis rs1129187 0.837 rs3763236 chr6:42902508 C/T cg27588902 chr6:42928151 GNMT 0.31 11.19 0.4 1.13e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2288073 0.801 rs72797831 chr2:24366829 G/A cg06627628 chr2:24431161 ITSN2 -0.57 -10.79 -0.39 4.66e-25 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.35 -0.31 4.19e-16 Electroencephalogram traits; BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.68e-24 Motion sickness; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg23708337 chr7:1209742 NA 0.68 10.69 0.39 1.18e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs754466 0.958 rs58916802 chr10:79695870 G/A cg17075019 chr10:79541650 NA -0.67 -12.3 -0.44 2.43e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6570726 0.791 rs11155432 chr6:145898761 T/C cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6714710 0.580 rs1838797 chr2:98454572 G/C cg26665480 chr2:98280029 ACTR1B 0.58 13.6 0.47 3.4e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs12618769 0.597 rs17504774 chr2:99135627 A/G cg10123293 chr2:99228465 UNC50 -0.41 -8.09 -0.3 2.98e-15 Bipolar disorder; BRCA cis rs7727544 0.684 rs2631363 chr5:131707095 A/G cg07395648 chr5:131743802 NA 0.4 9.95 0.37 8.89e-22 Blood metabolite levels; BRCA cis rs11711311 0.747 rs11928590 chr3:113343478 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -8.97 -0.33 3.26e-18 IgG glycosylation; BRCA cis rs67981189 0.896 rs1859468 chr14:71402290 C/G cg15816911 chr14:71606274 NA -0.37 -8.28 -0.31 7.4e-16 Schizophrenia; BRCA trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg15704280 chr7:45808275 SEPT13 -0.73 -14.66 -0.5 3.83e-42 Coronary artery disease; BRCA cis rs9283706 0.641 rs1990894 chr5:66331685 C/T cg11590213 chr5:66331682 MAST4 0.38 8.08 0.3 3.28e-15 Coronary artery disease; BRCA cis rs736408 0.812 rs6778329 chr3:52824610 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.32 10.19 0.37 1.07e-22 Bipolar disorder; BRCA cis rs1153858 1.000 rs12437887 chr15:45669094 G/A cg21132104 chr15:45694354 SPATA5L1 0.75 16.99 0.56 1.07e-53 Homoarginine levels; BRCA cis rs7267979 0.966 rs2261698 chr20:25259910 A/G cg08601574 chr20:25228251 PYGB 0.36 8.63 0.32 4.9e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.2 -0.31 1.37e-15 Menopause (age at onset); BRCA cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg18876405 chr7:65276391 NA -0.49 -10.22 -0.37 7.99e-23 Calcium levels; BRCA cis rs17401966 0.931 rs746881 chr1:10346810 C/T cg03954927 chr1:10346856 KIF1B -0.46 -14.45 -0.5 3.6700000000000003e-41 Hepatocellular carcinoma; BRCA cis rs17270561 0.779 rs12209218 chr6:25887776 C/A cg17691542 chr6:26056736 HIST1H1C 0.74 14.51 0.5 1.9e-41 Iron status biomarkers; BRCA cis rs250677 0.958 rs36067 chr5:148417553 T/G cg12140854 chr5:148520817 ABLIM3 -0.43 -9.07 -0.34 1.41e-18 Breast cancer; BRCA cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg02820040 chr2:241836501 C2orf54 -0.53 -10.03 -0.37 4.21e-22 Urinary metabolites; BRCA cis rs870825 0.616 rs28445002 chr4:185648977 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs2777491 1.000 rs316613 chr15:41747598 G/A cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.81 -0.53 9.47e-48 Ulcerative colitis; BRCA cis rs2455601 0.638 rs11042148 chr11:9008674 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.47 -8.43 -0.32 2.27e-16 Schizophrenia; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg22963979 chr7:1858916 MAD1L1 -0.39 -8.26 -0.31 8.64e-16 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.754 rs4107728 chr4:120253910 G/A cg09307838 chr4:120376055 NA 0.63 13.55 0.47 5.84e-37 Corneal astigmatism; BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg09263875 chr16:632152 PIGQ 0.71 20.46 0.63 6e-72 Height; BRCA cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.63 13.01 0.46 1.73e-34 Hip circumference adjusted for BMI; BRCA cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg21427119 chr20:30132790 HM13 -0.42 -8.9 -0.33 5.92e-18 Mean corpuscular hemoglobin; BRCA cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.04 15.74 0.53 1.94e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg11663144 chr21:46675770 NA -0.49 -9.7 -0.36 7.64e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7633770 0.786 rs4683256 chr3:46683617 T/G cg11219411 chr3:46661640 NA 0.65 16.96 0.56 1.59e-53 Coronary artery disease; BRCA cis rs10876993 0.890 rs1585781 chr12:58056701 T/G cg18357645 chr12:58087776 OS9 0.46 13.35 0.47 4.74e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg13319975 chr6:146136371 FBXO30 0.43 9.83 0.36 2.57e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.31 -0.56 2.53e-55 Chronic sinus infection; BRCA cis rs6088580 0.524 rs7274854 chr20:33228672 A/C cg24642439 chr20:33292090 TP53INP2 0.41 8.53 0.32 1.04e-16 Glomerular filtration rate (creatinine); BRCA cis rs7618915 1.000 rs3852063 chr3:52349204 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -9.97 -0.37 7.4e-22 Bipolar disorder; BRCA cis rs6582630 0.502 rs11520276 chr12:38359216 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.2 0.56 8.77e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.862 rs4149461 chr7:65744732 T/C cg11764359 chr7:65958608 NA -0.77 -17.87 -0.58 3.29e-58 Aortic root size; BRCA cis rs7044106 0.762 rs10760107 chr9:123383630 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 13.79 0.48 4.56e-38 Hip circumference adjusted for BMI; BRCA cis rs60843830 1.000 rs6709534 chr2:217334 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.7 13.72 0.48 9.58e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg17211192 chr8:82754475 SNX16 -0.53 -12.1 -0.43 1.69e-30 Diastolic blood pressure; BRCA cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.61 12.31 0.44 2.21e-31 Monocyte percentage of white cells; BRCA cis rs10197940 0.662 rs13555 chr2:152333304 C/A cg06191203 chr2:152266755 RIF1 -0.31 -9.05 -0.34 1.67e-18 Lung cancer; BRCA cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.49 0.5 2.37e-41 Motion sickness; BRCA cis rs4727027 0.870 rs62507512 chr7:148799338 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.89 0.33 6.4e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4631830 0.832 rs2843554 chr10:51523861 G/T cg20129853 chr10:51489980 NA -0.28 -7.83 -0.3 2.03e-14 Prostate-specific antigen levels; BRCA cis rs1008375 1.000 rs7688682 chr4:17693794 A/G cg02297831 chr4:17616191 MED28 -0.36 -8.55 -0.32 9.3e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6088590 0.523 rs6088536 chr20:33189106 T/C cg08999081 chr20:33150536 PIGU 0.5 14.14 0.49 1.03e-39 Coronary artery disease; BRCA cis rs13102973 0.965 rs28874134 chr4:135867088 C/A cg14419869 chr4:135874104 NA -0.59 -12.99 -0.46 2.06e-34 Subjective well-being; BRCA cis rs1534166 0.647 rs13321680 chr3:133507119 G/T cg01448562 chr3:133502909 NA 0.39 8.92 0.33 4.98e-18 Alcohol consumption (transferrin glycosylation); BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.86 0.6 2.15e-63 Alzheimer's disease; BRCA cis rs35934224 0.831 rs8141610 chr22:19870147 A/G cg11182965 chr22:19864308 TXNRD2 0.35 7.94 0.3 9.15e-15 Glaucoma (primary open-angle); BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.3 -0.31 6.38e-16 Gut microbiome composition (summer); BRCA cis rs654128 0.640 rs6914581 chr6:117228916 C/T cg12892004 chr6:117198278 RFX6 0.43 8.17 0.31 1.61e-15 Telomere length; BRCA cis rs2070433 0.539 rs2070432 chr21:47957332 G/A cg12379764 chr21:47803548 PCNT 0.6 12.27 0.44 3.25e-31 Lymphocyte counts; BRCA cis rs10927875 0.726 rs1763603 chr1:16339809 T/C cg06159980 chr1:16340746 HSPB7 -0.38 -7.82 -0.3 2.21e-14 Dilated cardiomyopathy; BRCA cis rs10899021 1.000 rs61900636 chr11:74359591 G/T cg25880958 chr11:74394337 NA -0.52 -8.11 -0.31 2.67e-15 Response to metformin (IC50); BRCA cis rs7737355 0.947 rs6864173 chr5:130871822 T/C cg06307176 chr5:131281290 NA 0.53 10.52 0.38 5.56e-24 Life satisfaction; BRCA cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35146811 0.700 rs858513 chr7:99825558 G/A cg22906224 chr7:99728672 NA -0.42 -7.98 -0.3 6.88e-15 Coronary artery disease; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg23358479 chr7:1110784 C7orf50 -0.47 -7.95 -0.3 8.4e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg11644478 chr21:40555479 PSMG1 0.84 19.09 0.6 1.21e-64 Cognitive function; BRCA cis rs7615952 0.599 rs6803160 chr3:125709554 G/T cg04553112 chr3:125709451 NA -0.58 -9.09 -0.34 1.26e-18 Blood pressure (smoking interaction); BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg24642844 chr7:1081250 C7orf50 -0.91 -16.39 -0.54 1.21e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6545883 0.602 rs11125871 chr2:61470126 C/T cg15711740 chr2:61764176 XPO1 0.44 10.82 0.39 3.55e-25 Tuberculosis; BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg08470875 chr2:26401718 FAM59B -0.77 -12.2 -0.43 6.34e-31 Gut microbiome composition (summer); BRCA cis rs7640424 0.649 rs13091474 chr3:107877134 A/T cg09227934 chr3:107805635 CD47 -0.37 -7.84 -0.3 1.9e-14 Body mass index; BRCA cis rs7592578 0.766 rs62181052 chr2:191387858 A/G cg11845111 chr2:191398756 TMEM194B -0.82 -14.54 -0.5 1.44e-41 Diastolic blood pressure; BRCA cis rs60843830 1.000 rs55936726 chr2:258210 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.47 0.5 3e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs698833 0.886 rs698824 chr2:44723123 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 10.07 0.37 3.03e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7100689 0.622 rs7090351 chr10:82142047 T/G cg00277334 chr10:82204260 NA -0.42 -8.57 -0.32 7.55e-17 Post bronchodilator FEV1; BRCA cis rs2425143 1.000 rs6058303 chr20:34290281 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.85 -0.33 8.76e-18 Blood protein levels; BRCA cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg09184832 chr6:79620586 NA -0.52 -11.42 -0.41 1.3e-27 Intelligence (multi-trait analysis); BRCA cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg11764359 chr7:65958608 NA 0.62 13.33 0.47 5.9e-36 Aortic root size; BRCA cis rs698833 0.926 rs786419 chr2:44685153 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.42 8.51 0.32 1.28e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs490234 0.812 rs4838268 chr9:128280315 G/T cg14078157 chr9:128172775 NA -0.34 -8.02 -0.3 5.06e-15 Mean arterial pressure; BRCA cis rs1113500 0.636 rs3853493 chr1:108637193 G/A cg06207961 chr1:108661230 NA 0.36 8.93 0.33 4.46e-18 Growth-regulated protein alpha levels; BRCA trans rs7824557 0.564 rs13260727 chr8:11232860 A/G cg15556689 chr8:8085844 FLJ10661 0.36 9.31 0.35 1.98e-19 Retinal vascular caliber; BRCA cis rs875971 1.000 rs778722 chr7:65844828 T/C cg18876405 chr7:65276391 NA 0.55 13.29 0.47 8.91e-36 Aortic root size; BRCA cis rs11997175 0.583 rs7824990 chr8:33779934 A/G ch.8.33884649F chr8:33765107 NA 0.36 8.25 0.31 8.75e-16 Body mass index; BRCA cis rs1371614 0.523 rs12468761 chr2:27183793 G/A cg00617064 chr2:27272375 NA 0.31 8.04 0.3 4.34e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg10523679 chr1:76189770 ACADM -0.47 -9.19 -0.34 5.31e-19 Daytime sleep phenotypes; BRCA cis rs6831352 0.918 rs13112733 chr4:100050319 A/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs6138458 1.000 rs2387362 chr20:24899906 C/T cg26195577 chr20:24973756 C20orf3 -0.98 -24.65 -0.7 8.06e-95 Blood protein levels; BRCA cis rs875971 1.000 rs12698523 chr7:65968113 C/G cg18876405 chr7:65276391 NA 0.55 13.12 0.46 5.35e-35 Aortic root size; BRCA cis rs4845875 0.530 rs6667720 chr1:11831615 A/G cg24844545 chr1:11908347 NPPA -0.36 -8.58 -0.32 7.46e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs4566357 0.615 rs2272202 chr2:227914625 C/T cg11843606 chr2:227700838 RHBDD1 0.42 9.43 0.35 7.69e-20 Coronary artery disease; BRCA trans rs1459104 0.866 rs12804916 chr11:54831763 G/A cg15704280 chr7:45808275 SEPT13 0.63 8.26 0.31 8.33e-16 Body mass index; BRCA cis rs30380 0.586 rs28119 chr5:96131733 G/A cg16492584 chr5:96139282 ERAP1 -0.47 -11.05 -0.4 4.34e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg00990874 chr7:1149470 C7orf50 -0.6 -12.14 -0.43 1.14e-30 Bronchopulmonary dysplasia; BRCA cis rs12541635 0.677 rs2880950 chr8:106983624 C/A cg10147462 chr8:107024639 NA 0.4 10.77 0.39 5.51e-25 Age of smoking initiation; BRCA cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg06618935 chr21:46677482 NA -0.36 -7.95 -0.3 8.52e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2762353 0.808 rs1165179 chr6:25826514 C/T cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA trans rs10435719 0.902 rs4840599 chr8:11805380 C/T cg16141378 chr3:129829833 LOC729375 0.32 8.03 0.3 4.72e-15 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs3806843 0.648 rs2530233 chr5:140082876 A/G cg26395211 chr5:140044315 WDR55 0.37 8.58 0.32 7.32e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs7809615 0.901 rs10226310 chr7:99118320 G/A cg12290671 chr7:99195819 NA -0.53 -8.93 -0.33 4.48e-18 Blood metabolite ratios; BRCA cis rs9649465 0.934 rs7799354 chr7:123269819 A/G cg04330084 chr7:123175371 IQUB -0.32 -8.85 -0.33 8.69e-18 Migraine; BRCA cis rs75229567 0.618 rs77168443 chr12:70208563 G/A cg10114359 chr12:70132523 RAB3IP 1.18 13.34 0.47 5.5e-36 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs7666738 0.830 rs7659420 chr4:98878714 G/C cg17366294 chr4:99064904 C4orf37 0.42 9.82 0.36 2.66e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs3008870 0.583 rs11208985 chr1:67464666 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.89 -16.53 -0.55 2.17e-51 Lymphocyte percentage of white cells; BRCA cis rs2842992 0.872 rs2758330 chr6:160104844 G/T cg11366901 chr6:160182831 ACAT2 0.77 14.95 0.51 1.47e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg08859206 chr1:53392774 SCP2 -0.55 -12.16 -0.43 9.37e-31 Monocyte count; BRCA cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg13114125 chr14:105738426 BRF1 -0.49 -10.39 -0.38 1.8e-23 Mean platelet volume;Platelet distribution width; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg13628971 chr7:2884303 GNA12 0.48 10.65 0.39 1.77e-24 Height; BRCA trans rs2832077 1.000 rs9983229 chr21:30137674 A/G cg14791747 chr16:20752902 THUMPD1 -0.39 -9.29 -0.34 2.41e-19 Cognitive test performance; BRCA cis rs2153535 0.541 rs6932434 chr6:8467679 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs17685 0.753 rs1639617 chr7:75701728 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.5 -0.32 1.31e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs12477438 0.559 rs6733285 chr2:99725575 T/C cg08885076 chr2:99613938 TSGA10 0.42 9.88 0.36 1.6e-21 Chronic sinus infection; BRCA cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.83 -0.33 1.01e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.83 0.33 9.93e-18 Motion sickness; BRCA trans rs9329221 0.662 rs9650650 chr8:10247976 C/T cg06636001 chr8:8085503 FLJ10661 0.52 10.2 0.37 9.54e-23 Neuroticism; BRCA cis rs3096299 0.658 rs4785679 chr16:89566113 G/T cg06640241 chr16:89574553 SPG7 0.88 23.1 0.67 2.54e-86 Multiple myeloma (IgH translocation); BRCA cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.25e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs62064224 0.589 rs9904964 chr17:30662832 A/G cg18200150 chr17:30822561 MYO1D -0.33 -8.53 -0.32 1.06e-16 Schizophrenia; BRCA cis rs6545883 0.894 rs12615783 chr2:61440947 T/C cg15711740 chr2:61764176 XPO1 0.5 12.19 0.43 7.15e-31 Tuberculosis; BRCA cis rs8072100 0.790 rs34200664 chr17:45744652 C/T cg08085267 chr17:45401833 C17orf57 0.63 12.86 0.45 7.82e-34 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9443645 0.869 rs6913028 chr6:79513590 C/T cg18132916 chr6:79620363 NA -0.46 -10.22 -0.37 8.56e-23 Intelligence (multi-trait analysis); BRCA cis rs244731 1.000 rs244731 chr5:176539679 C/T cg17509989 chr5:176798049 RGS14 0.73 11.76 0.42 4.93e-29 Urate levels in lean individuals; BRCA trans rs9329221 0.527 rs4841352 chr8:10327590 A/C cg06636001 chr8:8085503 FLJ10661 0.46 9.62 0.36 1.44e-20 Neuroticism; BRCA cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.13 0.37 1.79e-22 Cognitive ability; BRCA cis rs13191362 0.507 rs6907151 chr6:163200701 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.47 8.65 0.32 4.02e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10848704 1.000 rs10848704 chr12:2882544 A/G cg19995117 chr12:2880862 NA -0.47 -10.77 -0.39 5.54e-25 Quantitative traits; BRCA cis rs909002 0.830 rs10914461 chr1:32113217 G/A cg13919466 chr1:32135498 COL16A1 -0.26 -8.83 -0.33 9.76e-18 Intelligence (multi-trait analysis); BRCA cis rs4919087 1.000 rs10786329 chr10:99074621 G/A cg25902810 chr10:99078978 FRAT1 0.52 11.25 0.41 6.34e-27 Monocyte count; BRCA cis rs8062405 1.000 rs80275162 chr16:28863517 T/A cg09754948 chr16:28834200 ATXN2L 0.47 8.98 0.33 2.92e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg11062466 chr8:58055876 NA 0.51 8.92 0.33 4.88e-18 Developmental language disorder (linguistic errors); BRCA cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.77 11.03 0.4 5.15e-26 Initial pursuit acceleration; BRCA cis rs7772486 0.754 rs9390358 chr6:146145678 C/T cg13319975 chr6:146136371 FBXO30 -0.43 -10.1 -0.37 2.39e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs78487399 0.908 rs6715003 chr2:43808659 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.98 -0.3 6.71e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs7903847 0.642 rs11189182 chr10:99144186 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs77633900 0.614 rs2930681 chr15:76995150 G/A cg21673338 chr15:77095150 SCAPER -0.54 -9.91 -0.37 1.22e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs9921222 0.786 rs3848365 chr16:374617 C/T cg00101154 chr16:420108 MRPL28 -0.35 -8.03 -0.3 4.6e-15 Bone mineral density (spine);Bone mineral density; BRCA cis rs7944584 0.563 rs2280231 chr11:47600438 C/T cg03711944 chr11:47377212 SPI1 -0.44 -10.36 -0.38 2.41e-23 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs1372520 1.000 rs1372520 chr4:90757505 T/C cg15133208 chr4:90757351 SNCA -0.43 -8.76 -0.33 1.72e-17 Neuroticism; BRCA trans rs3733585 0.699 rs12498150 chr4:9950537 C/T cg26043149 chr18:55253948 FECH -0.36 -8.04 -0.3 4.33e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9462027 0.628 rs34141614 chr6:34777031 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.84 -0.3 1.96e-14 Systemic lupus erythematosus; BRCA cis rs6963495 0.818 rs73190186 chr7:105164368 G/C cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6089829 1.000 rs6089828 chr20:61668998 C/T cg02544614 chr20:61657117 NA 0.28 7.95 0.3 8.19e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg23711669 chr6:146136114 FBXO30 0.79 18.88 0.6 1.6e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs611744 0.647 rs587340 chr8:109246032 C/A cg21045802 chr8:109455806 TTC35 0.35 7.82 0.3 2.12e-14 Dupuytren's disease; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg18538332 chr22:24372958 LOC391322 0.54 13.12 0.46 5.71e-35 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2050392 0.767 rs1536833 chr10:30699265 C/T cg18806716 chr10:30721971 MAP3K8 0.59 13.69 0.48 1.33e-37 Inflammatory bowel disease; BRCA cis rs7927771 1.000 rs11039412 chr11:47841581 G/A cg18512352 chr11:47633146 NA -0.34 -8.32 -0.31 5.4e-16 Subjective well-being; BRCA cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg06618935 chr21:46677482 NA -0.36 -8.11 -0.31 2.68e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs6598955 0.671 rs12090258 chr1:26644698 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.25 -0.52 5.03e-45 Obesity-related traits; BRCA cis rs11718455 0.960 rs4682712 chr3:43997971 T/C cg08738300 chr3:44038990 NA 0.45 8.61 0.32 5.81e-17 Coronary artery disease; BRCA cis rs3099143 0.908 rs3102716 chr15:77051003 T/G cg21673338 chr15:77095150 SCAPER -0.53 -9.72 -0.36 6.45e-21 Recalcitrant atopic dermatitis; BRCA cis rs826838 1.000 rs826892 chr12:39100790 T/C cg13010199 chr12:38710504 ALG10B -0.42 -9.78 -0.36 3.79e-21 Heart rate; BRCA trans rs11098499 0.863 rs11736416 chr4:120431661 C/T cg25214090 chr10:38739885 LOC399744 0.55 12.23 0.44 4.59e-31 Corneal astigmatism; BRCA cis rs35306767 0.903 rs1341741 chr10:888073 A/G cg20503657 chr10:835505 NA 0.93 16.56 0.55 1.66e-51 Eosinophil percentage of granulocytes; BRCA cis rs7551345 0.653 rs56125362 chr1:31698765 G/A cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.17e-22 Schizophrenia; BRCA cis rs7584330 0.744 rs58223447 chr2:238378644 G/C cg14458575 chr2:238380390 NA 0.76 16.63 0.55 6.82e-52 Prostate cancer; BRCA cis rs6701037 1.000 rs12747817 chr1:175118895 C/T cg00321850 chr1:175162397 KIAA0040 -0.41 -11.54 -0.42 3.93e-28 Alcohol dependence; BRCA cis rs7631605 0.875 rs7638620 chr3:37200085 A/G cg15934958 chr3:37212084 LRRFIP2 0.42 9.76 0.36 4.55e-21 Cerebrospinal P-tau181p levels; BRCA cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg17971929 chr21:40555470 PSMG1 -0.62 -13.67 -0.48 1.72e-37 Cognitive function; BRCA cis rs7772486 0.686 rs9403741 chr6:146030548 G/A cg13319975 chr6:146136371 FBXO30 0.34 7.87 0.3 1.47e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs2637030 0.559 rs2637024 chr5:52993453 A/G cg06476337 chr5:52856530 NDUFS4 0.37 8.47 0.32 1.67e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs5771069 0.931 rs137864 chr22:50446988 C/T cg27068297 chr22:50451975 IL17REL 0.33 7.89 0.3 1.3e-14 Ulcerative colitis; BRCA cis rs6570726 0.526 rs7755237 chr6:145731852 T/C cg23711669 chr6:146136114 FBXO30 -0.48 -10.56 -0.39 3.9e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742234 0.541 rs7098236 chr10:43740508 T/C cg15436174 chr10:43711423 RASGEF1A 0.5 9.97 0.37 7.18e-22 Hirschsprung disease; BRCA cis rs4764124 0.571 rs11830399 chr12:14956932 G/C cg19759883 chr12:14956454 WBP11;C12orf60 0.5 11.44 0.41 1.05e-27 Pubertal anthropometrics; BRCA cis rs977987 0.806 rs4993970 chr16:75411619 G/A cg03315344 chr16:75512273 CHST6 0.53 12.62 0.45 9.48e-33 Dupuytren's disease; BRCA cis rs55692411 0.537 rs62262118 chr3:50003586 G/A cg14019146 chr3:50243930 SLC38A3 -0.57 -11.69 -0.42 9.96e-29 Intelligence (multi-trait analysis); BRCA cis rs9290065 0.538 rs6809206 chr3:160755708 G/A cg03342759 chr3:160939853 NMD3 -0.53 -10.74 -0.39 7.56e-25 Kawasaki disease; BRCA cis rs2404602 0.647 rs12910820 chr15:77022825 T/C cg23625390 chr15:77176239 SCAPER -0.56 -14.03 -0.49 3.43e-39 Blood metabolite levels; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg27170947 chr2:26402098 FAM59B 0.98 15.28 0.52 3.87e-45 Gut microbiome composition (summer); BRCA trans rs11098499 0.505 rs75122014 chr4:120362426 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.97 0.3 7.32e-15 Corneal astigmatism; BRCA cis rs6840360 0.615 rs28659854 chr4:152607442 T/C cg22705602 chr4:152727874 NA -0.38 -10.34 -0.38 2.7e-23 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.620 rs2101582 chr6:26622734 C/T cg11502198 chr6:26597334 ABT1 0.56 12.1 0.43 1.75e-30 Intelligence (multi-trait analysis); BRCA cis rs11605275 1.000 rs11605275 chr11:20031865 C/T cg14835545 chr11:20032148 NAV2 -0.6 -8.96 -0.33 3.54e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9858542 0.537 rs9873994 chr3:49359943 T/C cg00383909 chr3:49044727 WDR6 0.5 9.67 0.36 9.49e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7772486 0.754 rs857881 chr6:145970793 C/A cg23711669 chr6:146136114 FBXO30 -0.79 -18.84 -0.6 2.71e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs9325144 0.555 rs2387855 chr12:38687964 T/G cg26384229 chr12:38710491 ALG10B 0.51 13.57 0.47 4.68e-37 Morning vs. evening chronotype; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg07343612 chr16:622815 PIGQ -0.68 -22.29 -0.66 6.92e-82 Height; BRCA cis rs936229 0.768 rs11072509 chr15:75114374 C/G cg14664628 chr15:75095509 CSK -0.95 -29.18 -0.76 1.26e-119 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA trans rs7829975 0.564 rs2976855 chr8:8301794 G/A cg16141378 chr3:129829833 LOC729375 -0.35 -8.64 -0.32 4.57e-17 Mood instability; BRCA cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.52 10.62 0.39 2.34e-24 Personality dimensions; BRCA cis rs67981189 0.896 rs1018977 chr14:71400653 G/T cg15816911 chr14:71606274 NA -0.37 -8.23 -0.31 1.04e-15 Schizophrenia; BRCA cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.38 -0.31 3.28e-16 Colorectal cancer; BRCA trans rs6600671 0.899 rs2319971 chr1:121226982 A/C cg17023122 chr1:144479586 NA 0.35 7.99 0.3 6.19e-15 Hip geometry; BRCA cis rs250677 0.522 rs919731 chr5:148352150 T/C cg18129178 chr5:148520854 ABLIM3 0.54 10.52 0.38 5.62e-24 Breast cancer; BRCA cis rs1865760 0.686 rs12210098 chr6:25963966 C/T cg16482183 chr6:26056742 HIST1H1C 0.56 10.98 0.4 7.82e-26 Height; BRCA cis rs2742234 0.910 rs2505505 chr10:43648221 G/T cg15436174 chr10:43711423 RASGEF1A -0.43 -9.18 -0.34 5.98e-19 Hirschsprung disease; BRCA cis rs3008870 1.000 rs2985811 chr1:67377722 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.49 0.65 1.55e-77 Lymphocyte percentage of white cells; BRCA cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.73 0.33 2.16e-17 Personality dimensions; BRCA cis rs9467773 0.620 rs9467810 chr6:26608261 A/C cg09904177 chr6:26538194 HMGN4 0.47 15.02 0.51 7.17e-44 Intelligence (multi-trait analysis); BRCA cis rs6912958 0.712 rs9444526 chr6:88326402 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.4 -0.32 2.79e-16 Monocyte percentage of white cells; BRCA cis rs796364 0.951 rs72932280 chr2:200996851 G/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.55 -9.48 -0.35 4.75e-20 Schizophrenia; BRCA cis rs7552404 0.727 rs2172508 chr1:76320215 A/G cg03433033 chr1:76189801 ACADM 0.7 13.73 0.48 8.8e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17376456 0.877 rs9314099 chr5:93447375 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.07 0.3 3.57e-15 Diabetic retinopathy; BRCA cis rs4880487 0.888 rs67699390 chr10:1252427 G/A cg03183215 chr10:1252341 ADARB2 -0.39 -8.8 -0.33 1.32e-17 Migraine; BRCA cis rs9682041 0.877 rs9682908 chr3:170072010 C/T cg11886554 chr3:170076028 SKIL 0.52 10.71 0.39 1.03e-24 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA trans rs17685 0.712 rs11764119 chr7:75812358 T/G cg19862616 chr7:65841803 NCRNA00174 0.79 24.71 0.7 3.87e-95 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9527 0.590 rs11191578 chr10:104902337 A/T cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs1832871 0.655 rs6920121 chr6:158678504 C/T cg07215822 chr6:158701037 NA 0.5 8.01 0.3 5.61e-15 Height; BRCA cis rs9287719 0.639 rs2357650 chr2:10696877 C/T cg00105475 chr2:10696890 NA 0.55 13.27 0.46 1.18e-35 Prostate cancer; BRCA cis rs1018836 0.923 rs1858674 chr8:91580665 G/T cg16814680 chr8:91681699 NA -0.58 -12.38 -0.44 1.09e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs2760061 0.598 rs2796056 chr1:228122901 G/A cg02753203 chr1:228287806 NA -0.6 -12.95 -0.46 3.31e-34 Diastolic blood pressure; BRCA cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2072499 0.966 rs2842857 chr1:156168736 T/C cg06970220 chr1:156163860 SLC25A44 0.39 9.56 0.35 2.54e-20 Testicular germ cell tumor; BRCA cis rs13102973 0.932 rs4130841 chr4:135869673 T/C cg14419869 chr4:135874104 NA -0.59 -12.99 -0.46 2.2e-34 Subjective well-being; BRCA cis rs6878727 1.000 rs6878727 chr5:123736406 A/G cg01806427 chr5:123737813 NA 0.39 8.88 0.33 6.98e-18 Breast cancer; BRCA cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg20476274 chr7:133979776 SLC35B4 0.65 19.4 0.61 2.78e-66 Mean platelet volume; BRCA cis rs2243480 1.000 rs6964245 chr7:65718717 G/A cg18252515 chr7:66147081 NA 1.04 15.68 0.53 3.96e-47 Diabetic kidney disease; BRCA cis rs72781680 0.612 rs33913065 chr2:24344060 T/G cg08917208 chr2:24149416 ATAD2B 0.51 7.88 0.3 1.37e-14 Lymphocyte counts; BRCA cis rs12142240 0.698 rs10158236 chr1:46820896 G/T cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.03 19.54 0.61 4.85e-67 Platelet count; BRCA trans rs7939886 0.920 rs1586014 chr11:55771540 C/T cg15704280 chr7:45808275 SEPT13 0.62 7.83 0.3 2.05e-14 Myopia (pathological); BRCA cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg01028140 chr2:1542097 TPO -0.79 -15.58 -0.52 1.28e-46 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs11039798 0.588 rs3924476 chr11:48581733 T/C cg15704280 chr7:45808275 SEPT13 0.51 8.7 0.33 2.89e-17 Axial length; BRCA cis rs4363385 0.818 rs1591736 chr1:152987497 A/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.35 -0.31 4.35e-16 Inflammatory skin disease; BRCA cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg21770322 chr7:97807741 LMTK2 0.41 10.97 0.4 8.81e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs1348850 0.914 rs4893950 chr2:178304885 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.93 0.37 1.08e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs2840044 1.000 rs225251 chr17:33951228 A/C cg19694781 chr19:47549865 TMEM160 -0.46 -10.73 -0.39 8.11e-25 Response to radiotherapy in cancer (late toxicity); BRCA trans rs4596713 0.538 rs11145460 chr9:71766091 T/G cg16512924 chr15:28394682 HERC2 0.44 10.41 0.38 1.53e-23 Headache; BRCA cis rs7666738 0.830 rs6846739 chr4:99016647 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4853036 0.723 rs35690619 chr2:70053619 A/T cg02498382 chr2:70120550 SNRNP27 -0.54 -8.75 -0.33 1.82e-17 Colorectal or endometrial cancer; BRCA cis rs4595586 0.545 rs2197940 chr12:39401937 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.43 0.35 7.36e-20 Morning vs. evening chronotype; BRCA trans rs6952808 0.723 rs60995052 chr7:2030007 G/C cg04565464 chr8:145669602 NFKBIL2 0.38 8.93 0.33 4.59e-18 Bipolar disorder and schizophrenia; BRCA trans rs9329221 0.698 rs12547997 chr8:10260837 A/G cg06636001 chr8:8085503 FLJ10661 0.44 8.73 0.33 2.22e-17 Neuroticism; BRCA cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs10267417 0.603 rs10263119 chr7:19872844 C/G cg05791153 chr7:19748676 TWISTNB 0.48 9.19 0.34 5.63e-19 Night sleep phenotypes; BRCA cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg13010199 chr12:38710504 ALG10B 0.53 11.07 0.4 3.38e-26 Heart rate; BRCA cis rs425277 0.958 rs626479 chr1:2110260 A/G cg24578937 chr1:2090814 PRKCZ -0.56 -17.5 -0.57 2.49e-56 Height; BRCA cis rs8017423 0.967 rs8009493 chr14:90690083 G/C cg14092571 chr14:90743983 NA -0.34 -8.07 -0.3 3.4e-15 Mortality in heart failure; BRCA cis rs12971120 0.891 rs3764510 chr18:72166846 A/G cg25817165 chr18:72167213 CNDP2 -0.76 -14.14 -0.49 1.14e-39 Refractive error; BRCA cis rs7786877 0.723 rs7812235 chr7:100211486 G/C cg20848291 chr7:100343083 ZAN -0.58 -10.69 -0.39 1.19e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg26608667 chr7:1196370 ZFAND2A 0.37 8.37 0.31 3.65e-16 Longevity;Endometriosis; BRCA cis rs12200782 0.530 rs6929908 chr6:26555289 C/A cg11502198 chr6:26597334 ABT1 0.6 9.21 0.34 4.6e-19 Small cell lung carcinoma; BRCA cis rs6546550 0.901 rs10167142 chr2:70062360 T/C cg02498382 chr2:70120550 SNRNP27 -0.5 -10.46 -0.38 9.25e-24 Prevalent atrial fibrillation; BRCA cis rs9287719 0.649 rs10190673 chr2:10718618 T/C cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.62e-19 Prostate cancer; BRCA cis rs11051970 0.636 rs2733704 chr12:32567858 C/T cg24626660 chr12:32551988 NA 0.31 9.22 0.34 4.38e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6963495 0.818 rs73190161 chr7:105156871 C/T cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs877282 0.945 rs10904556 chr10:789429 A/G cg17470449 chr10:769945 NA 0.47 8.16 0.31 1.73e-15 Uric acid levels; BRCA trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.41 -0.38 1.47e-23 Blood protein levels; BRCA cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 13.97 0.48 6.83e-39 Colorectal cancer; BRCA cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11890956 chr21:40555474 PSMG1 -0.81 -19.07 -0.6 1.7e-64 Cognitive function; BRCA cis rs7250872 0.647 rs2304612 chr19:1817866 A/G cg05970437 chr19:1864622 KLF16 -0.41 -7.81 -0.3 2.31e-14 Bipolar disorder; BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg03354898 chr7:1950403 MAD1L1 -0.41 -8.2 -0.31 1.35e-15 Bipolar disorder and schizophrenia; BRCA cis rs853679 0.517 rs3757185 chr6:28107776 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.12 0.31 2.38e-15 Depression; BRCA cis rs4671400 0.516 rs1809028 chr2:61413723 A/G cg15711740 chr2:61764176 XPO1 -0.46 -8.79 -0.33 1.43e-17 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs35110281 0.776 rs9306159 chr21:45061839 G/T cg21573476 chr21:45109991 RRP1B -0.36 -9.09 -0.34 1.25e-18 Mean corpuscular volume; BRCA cis rs495337 1.000 rs615926 chr20:48519258 T/C cg17835207 chr20:48524531 SPATA2 -0.63 -14.47 -0.5 3.06e-41 Psoriasis; BRCA cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg01256987 chr12:42539512 GXYLT1 -0.47 -9.25 -0.34 3.27e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs11105298 0.891 rs10858894 chr12:89914261 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.64 -0.36 1.23e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs11105298 0.891 rs10858851 chr12:89830870 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.66 -0.36 1.09e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg25173405 chr17:45401733 C17orf57 -0.51 -10.59 -0.39 2.89e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9788682 0.747 rs2938671 chr15:78732754 A/G cg24631222 chr15:78858424 CHRNA5 -0.5 -10.03 -0.37 4.38e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7119 0.717 rs11629652 chr15:77779951 C/A cg17802220 chr15:77601643 NA -0.47 -10.39 -0.38 1.81e-23 Type 2 diabetes; BRCA cis rs9473147 0.571 rs9369717 chr6:47554468 T/G cg12968598 chr6:47444699 CD2AP 0.46 9.74 0.36 5.58e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 7e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs7618501 0.602 rs2624853 chr3:50128893 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.31 -0.35 1.97e-19 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.908 rs2017057 chr4:120257711 A/G cg09307838 chr4:120376055 NA 0.69 14.38 0.49 7.56e-41 Corneal astigmatism; BRCA cis rs769267 0.831 rs2872878 chr19:19480521 G/C cg26732615 chr19:19648335 CILP2;YJEFN3 -0.37 -8.0 -0.3 5.76e-15 Tonsillectomy; BRCA cis rs67460515 0.563 rs9883566 chr3:160770323 C/T cg03342759 chr3:160939853 NMD3 0.62 12.54 0.44 1.99e-32 Parkinson's disease; BRCA trans rs11098499 0.866 rs13125526 chr4:120288019 G/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs8072100 0.570 rs9905073 chr17:45468296 G/A cg25173405 chr17:45401733 C17orf57 -0.52 -10.72 -0.39 8.84e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11098499 0.909 rs71614422 chr4:120359340 G/A cg09307838 chr4:120376055 NA 0.74 15.99 0.53 1.23e-48 Corneal astigmatism; BRCA cis rs12477438 0.798 rs7606635 chr2:99644782 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.75 -0.53 1.79e-47 Chronic sinus infection; BRCA cis rs7312933 1.000 rs7957213 chr12:42475438 T/G cg17420585 chr12:42539391 GXYLT1 -0.49 -10.61 -0.39 2.57e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7666738 0.830 rs4699603 chr4:99056172 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.5 0.57 2.57e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg23033748 chr14:75592666 NEK9 -0.38 -9.26 -0.34 3.02e-19 Height; BRCA cis rs780096 0.546 rs6547626 chr2:27646770 C/T cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.52 -0.32 1.13e-16 Total body bone mineral density; BRCA cis rs6570726 0.791 rs9403730 chr6:145907233 C/T cg13319975 chr6:146136371 FBXO30 -0.36 -8.16 -0.31 1.73e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg11814155 chr7:99998594 ZCWPW1 0.48 8.81 0.33 1.22e-17 Platelet count; BRCA trans rs7786808 0.741 rs62479982 chr7:158227546 A/G cg02030672 chr11:45687055 CHST1 0.39 8.31 0.31 5.86e-16 Obesity-related traits; BRCA cis rs2882667 0.587 rs2174972 chr5:138101918 C/G cg04439458 chr5:138467593 SIL1 0.31 7.85 0.3 1.74e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1506636 1.000 rs7779099 chr7:123295964 C/T cg03229431 chr7:123269106 ASB15 -0.64 -14.3 -0.49 1.95e-40 Plateletcrit;Platelet count; BRCA trans rs9354352 0.784 rs2062327 chr6:66689923 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.64 -13.78 -0.48 5.12e-38 Initial pursuit acceleration in psychotic disorders; BRCA cis rs2019137 0.539 rs4849177 chr2:113982584 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.66 13.56 0.47 5.14e-37 Lymphocyte counts; BRCA cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg05623727 chr3:50126028 RBM5 0.42 8.05 0.3 4.06e-15 Intelligence (multi-trait analysis); BRCA cis rs7607369 0.559 rs4674339 chr2:219659787 C/G cg02176678 chr2:219576539 TTLL4 -0.39 -10.42 -0.38 1.35e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs9329221 0.537 rs6983332 chr8:9977918 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -10.09 -0.37 2.56e-22 Neuroticism; BRCA trans rs1945213 0.694 rs1384088 chr11:55848713 G/C cg15704280 chr7:45808275 SEPT13 -0.63 -11.16 -0.4 1.54e-26 Acute lymphoblastic leukemia (childhood); BRCA cis rs654950 0.806 rs7550496 chr1:42043834 G/A cg06885757 chr1:42089581 HIVEP3 0.3 10.2 0.37 9.45e-23 Airway imaging phenotypes; BRCA cis rs2732480 0.577 rs2732481 chr12:48736985 T/G cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 6.07e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs9527 0.615 rs2152915 chr10:104691732 A/T cg04362960 chr10:104952993 NT5C2 0.45 10.43 0.38 1.31e-23 Arsenic metabolism; BRCA cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg08213375 chr14:104286397 PPP1R13B 0.62 17.71 0.57 2.12e-57 Schizophrenia; BRCA cis rs9790314 0.663 rs17826438 chr3:160640295 C/T cg03342759 chr3:160939853 NMD3 0.45 8.63 0.32 4.75e-17 Morning vs. evening chronotype; BRCA cis rs138880 0.542 rs9616393 chr22:50314809 A/G cg22709217 chr22:50311962 ALG12;CRELD2 0.52 8.08 0.3 3.17e-15 Schizophrenia; BRCA cis rs4319547 0.695 rs4758666 chr12:122902840 C/T cg23029597 chr12:123009494 RSRC2 -0.47 -9.69 -0.36 8.08e-21 Body mass index; BRCA cis rs9399135 0.967 rs12527683 chr6:135324534 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.18 0.43 7.58e-31 Red blood cell count; BRCA cis rs10851411 0.559 rs62019322 chr15:42897374 T/C cg21293051 chr15:42870591 STARD9 0.56 9.05 0.34 1.75e-18 Glucose homeostasis traits; BRCA cis rs7267979 0.903 rs2474769 chr20:25248725 C/T cg08601574 chr20:25228251 PYGB 0.38 9.19 0.34 5.5e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.754 rs6915718 chr6:146100676 A/G cg13319975 chr6:146136371 FBXO30 0.44 10.22 0.37 8.16e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs4268898 0.722 rs12185638 chr2:24382030 C/G cg26838691 chr2:24397539 C2orf84 0.41 8.26 0.31 8.67e-16 Asthma; BRCA trans rs2204008 0.603 rs4397954 chr12:38089157 T/C cg06521331 chr12:34319734 NA -0.56 -9.58 -0.35 2.04e-20 Bladder cancer; BRCA cis rs4819052 0.851 rs2236443 chr21:46678174 T/C cg11663144 chr21:46675770 NA -0.53 -12.24 -0.44 4.1e-31 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2637266 1.000 rs12783273 chr10:78353221 T/C cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg05283184 chr6:79620031 NA -0.35 -7.95 -0.3 8.28e-15 Intelligence (multi-trait analysis); BRCA cis rs8062405 1.000 rs1987472 chr16:28825777 C/T cg09754948 chr16:28834200 ATXN2L 0.45 9.03 0.34 2.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs67460515 0.596 rs35589595 chr3:160930984 G/A cg03342759 chr3:160939853 NMD3 -0.74 -15.57 -0.52 1.44e-46 Parkinson's disease; BRCA cis rs113835537 0.529 rs2279865 chr11:66203025 A/C cg24851651 chr11:66362959 CCS 0.41 7.99 0.3 6.24e-15 Airway imaging phenotypes; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg18402987 chr7:1209562 NA 0.53 10.45 0.38 1.08e-23 Longevity;Endometriosis; BRCA cis rs7914558 1.000 rs7071373 chr10:104771922 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.55 0.39 4.27e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg23248424 chr5:179741104 GFPT2 -0.62 -12.94 -0.46 3.43e-34 Height; BRCA cis rs1904096 0.506 rs6532476 chr4:95192461 C/A cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.26 -0.38 5.74e-23 Type 2 diabetes; BRCA cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg03684893 chr10:554711 DIP2C -0.36 -7.98 -0.3 6.75e-15 Psychosis in Alzheimer's disease; BRCA cis rs4363385 0.934 rs1415964 chr1:152955085 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -7.96 -0.3 7.61e-15 Inflammatory skin disease; BRCA cis rs11120822 0.787 rs11120829 chr1:7123793 A/C cg20434152 chr1:7120926 CAMTA1 -0.38 -9.45 -0.35 6.23e-20 Stearic acid (18:0) levels; BRCA cis rs34779708 0.931 rs11010077 chr10:35328088 C/T cg03585969 chr10:35415529 CREM -0.43 -9.23 -0.34 3.76e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7666738 0.791 rs7377018 chr4:99034962 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs6089829 0.962 rs6089826 chr20:61668595 G/A cg23505145 chr19:12996616 KLF1 0.54 12.34 0.44 1.49e-31 Prostate cancer (SNP x SNP interaction); BRCA trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21659725 chr3:3221576 CRBN 0.48 12.1 0.43 1.67e-30 Intelligence (multi-trait analysis); BRCA cis rs754466 1.000 rs12220902 chr10:79682918 C/T cg17075019 chr10:79541650 NA -0.57 -11.04 -0.4 4.53e-26 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg10523679 chr1:76189770 ACADM 0.68 12.76 0.45 2.34e-33 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11098499 0.863 rs6858592 chr4:120458692 G/A cg09307838 chr4:120376055 NA 0.69 14.85 0.51 4.44e-43 Corneal astigmatism; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.6 -11.41 -0.41 1.38e-27 Gut microbiome composition (summer); BRCA cis rs873946 0.590 rs12783478 chr10:134550700 A/G cg06453172 chr10:134556979 INPP5A -0.53 -11.49 -0.41 6.44e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7020830 0.931 rs9775431 chr9:37130433 G/A cg14294708 chr9:37120828 ZCCHC7 1.06 31.7 0.78 2.96e-133 Schizophrenia; BRCA cis rs7772486 0.875 rs6934467 chr6:146410529 G/T cg05347473 chr6:146136440 FBXO30 0.42 8.07 0.3 3.51e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg03477792 chr4:77819574 ANKRD56 0.65 15.44 0.52 5.85e-46 Emphysema distribution in smoking; BRCA cis rs10838687 0.610 rs4647737 chr11:47253244 T/G cg25783544 chr11:47291846 MADD 0.43 7.97 0.3 7.52e-15 Proinsulin levels; BRCA trans rs6499188 0.522 rs10153230 chr16:68671741 C/G cg04657470 chr2:198365150 HSPE1;HSPD1 0.47 8.88 0.33 6.45e-18 Ulcerative colitis; BRCA cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg26597838 chr10:835615 NA 0.9 15.21 0.52 8.03e-45 Eosinophil percentage of granulocytes; BRCA cis rs7100689 0.556 rs3120976 chr10:82025682 C/A cg01528321 chr10:82214614 TSPAN14 0.74 16.68 0.55 3.86e-52 Post bronchodilator FEV1; BRCA cis rs17345786 0.954 rs17508319 chr3:101318903 G/A cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.53 -0.38 5.07e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg07636037 chr3:49044803 WDR6 -0.6 -8.16 -0.31 1.84e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7666738 0.753 rs13122897 chr4:98936185 C/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg08847533 chr14:75593920 NEK9 -0.93 -24.06 -0.69 1.38e-91 Height; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg09263875 chr16:632152 PIGQ 0.72 21.49 0.65 1.57e-77 Height; BRCA cis rs7264396 0.635 rs2425166 chr20:34439391 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.4 -0.52 9.89e-46 Total cholesterol levels; BRCA cis rs595982 0.527 rs12151238 chr19:49368613 T/C cg21252483 chr19:49399788 TULP2 -0.4 -9.06 -0.34 1.52e-18 Red cell distribution width; BRCA cis rs4363385 0.818 rs3806223 chr1:153002646 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.83e-16 Inflammatory skin disease; BRCA cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 -0.56 -12.44 -0.44 5.98e-32 Platelet count; BRCA cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg24069376 chr3:38537580 EXOG 0.34 9.37 0.35 1.24e-19 Electrocardiographic conduction measures; BRCA cis rs7662987 0.517 rs2851256 chr4:100039549 G/A cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg04267008 chr7:1944627 MAD1L1 -0.4 -8.81 -0.33 1.14e-17 Schizophrenia; BRCA cis rs1113500 0.787 rs11185266 chr1:108642664 G/A cg06207961 chr1:108661230 NA 0.37 8.9 0.33 5.89e-18 Growth-regulated protein alpha levels; BRCA cis rs7254827 0.737 rs16981580 chr19:17173826 T/C cg19418318 chr19:17219073 MYO9B -0.48 -10.04 -0.37 3.85e-22 Mean platelet volume; BRCA cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg13175981 chr1:150552382 MCL1 0.42 9.45 0.35 6.31e-20 Tonsillectomy; BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg04944784 chr2:26401820 FAM59B -1.02 -17.43 -0.57 6.26e-56 Gut microbiome composition (summer); BRCA cis rs1538970 0.924 rs11211117 chr1:45930246 C/T cg05343316 chr1:45956843 TESK2 0.64 13.16 0.46 3.46e-35 Platelet count; BRCA cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg07537917 chr2:241836409 C2orf54 -0.49 -11.64 -0.42 1.6e-28 Urinary metabolites; BRCA cis rs10931896 0.531 rs295117 chr2:201146828 C/T cg23649088 chr2:200775458 C2orf69 0.43 9.2 0.34 4.89e-19 Systolic blood pressure; BRCA cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg21926612 chr6:163149169 PACRG;PARK2 1.07 16.15 0.54 1.79e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2070488 1.000 rs2276540 chr3:38512507 G/A cg24069376 chr3:38537580 EXOG 0.42 11.99 0.43 5.33e-30 Electrocardiographic conduction measures; BRCA cis rs11105298 0.891 rs10858900 chr12:89925081 C/A cg00757033 chr12:89920650 WDR51B 0.54 11.14 0.4 1.78e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs5756813 0.661 rs6000898 chr22:38202399 T/C cg19894588 chr14:64061835 NA -0.55 -11.54 -0.42 4.17e-28 Optic cup area;Vertical cup-disc ratio; BRCA cis rs477895 0.838 rs2070765 chr11:64010085 A/G cg04317338 chr11:64019027 PLCB3 0.56 9.53 0.35 3.13e-20 Mean platelet volume; BRCA cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.87 -0.33 7.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs1568889 0.887 rs7102237 chr11:28344296 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.75 19.31 0.61 8.49e-66 Bipolar disorder; BRCA cis rs1336900 0.641 rs6587756 chr1:150546865 A/T cg13175981 chr1:150552382 MCL1 0.37 7.94 0.3 9.22e-15 Blood protein levels; BRCA cis rs8072100 0.713 rs1912486 chr17:45515167 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -11.98 -0.43 5.79e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6424115 0.557 rs35904775 chr1:24180623 T/C cg10978503 chr1:24200527 CNR2 -0.52 -13.74 -0.48 8.06e-38 Immature fraction of reticulocytes; BRCA trans rs208520 0.690 rs1580430 chr6:66715162 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.92 19.41 0.61 2.52e-66 Exhaled nitric oxide output; BRCA cis rs2032447 0.831 rs9467664 chr6:26021813 A/T cg12310025 chr6:25882481 NA -0.55 -12.35 -0.44 1.46e-31 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.01e-40 Motion sickness; BRCA trans rs75804782 0.521 rs72982598 chr2:239455052 G/A cg01134436 chr17:81009848 B3GNTL1 0.58 8.17 0.31 1.65e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs910316 0.737 rs2098251 chr14:75492696 G/A cg23033748 chr14:75592666 NEK9 0.34 8.02 0.3 5e-15 Height; BRCA cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.82e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs4960423 chr6:8477210 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs9868809 0.505 rs11706203 chr3:48746239 T/A cg01304814 chr3:48885189 PRKAR2A 0.56 7.91 0.3 1.12e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7267979 0.932 rs433352 chr20:25467992 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.87 -0.33 7.1e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs870825 0.616 rs2310110 chr4:185647902 G/A cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs67981189 0.593 rs2240341 chr14:71373580 T/C cg15816911 chr14:71606274 NA -0.38 -8.62 -0.32 5.26e-17 Schizophrenia; BRCA cis rs12541635 0.966 rs2345070 chr8:107072027 A/G cg10147462 chr8:107024639 NA -0.37 -9.77 -0.36 4.03e-21 Age of smoking initiation; BRCA trans rs9858542 1.000 rs2172252 chr3:49678307 A/T cg21659725 chr3:3221576 CRBN -0.47 -9.68 -0.36 8.71e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7560272 0.695 rs780393 chr2:73701669 T/A cg20560298 chr2:73613845 ALMS1 0.43 11.64 0.42 1.57e-28 Schizophrenia; BRCA trans rs629535 0.514 rs55653755 chr8:70154383 A/C cg21567404 chr3:27674614 NA -0.96 -17.52 -0.57 2.09e-56 Dupuytren's disease; BRCA cis rs17376456 0.825 rs13171131 chr5:93223028 C/T cg21475434 chr5:93447410 FAM172A 0.68 8.61 0.32 5.66e-17 Diabetic retinopathy; BRCA cis rs4642101 0.512 rs9813960 chr3:12818205 A/G cg24848339 chr3:12840334 CAND2 0.45 11.95 0.43 7.32e-30 QRS complex (12-leadsum); BRCA cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg00409905 chr10:38381863 ZNF37A -0.48 -10.19 -0.37 1.04e-22 Extrinsic epigenetic age acceleration; BRCA cis rs6912958 0.967 rs9450688 chr6:88159276 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -9.06 -0.34 1.52e-18 Monocyte percentage of white cells; BRCA cis rs40363 0.645 rs6501177 chr16:3523681 C/T cg05754148 chr16:3507555 NAT15 0.38 7.96 0.3 8.04e-15 Tuberculosis; BRCA trans rs6598955 0.616 rs11247890 chr1:26590182 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.16 -0.54 1.65e-49 Obesity-related traits; BRCA cis rs858239 0.730 rs858289 chr7:23248158 C/T cg23682824 chr7:23144976 KLHL7 0.31 7.95 0.3 8.52e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22590775 chr19:49891494 CCDC155 0.45 8.0 0.3 5.81e-15 Multiple sclerosis; BRCA cis rs7666738 0.830 rs6831925 chr4:98947401 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.37e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg17366294 chr4:99064904 C4orf37 0.42 9.72 0.36 6.54e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs16958440 0.867 rs12386076 chr18:44673340 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.88 0.48 1.7e-38 Sitting height ratio; BRCA cis rs965469 0.779 rs967366 chr20:3266935 T/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.81 -0.33 1.17e-17 IFN-related cytopenia; BRCA cis rs870825 0.616 rs28563856 chr4:185635581 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.89e-54 Blood protein levels; BRCA cis rs1448094 0.512 rs12314274 chr12:86249196 A/G cg19622623 chr12:86230825 RASSF9 -0.34 -9.71 -0.36 7.07e-21 Major depressive disorder; BRCA cis rs6598955 0.543 rs3795687 chr1:26560745 G/A cg12744634 chr1:26560303 CCDC21 0.31 8.7 0.33 2.81e-17 Obesity-related traits; BRCA cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg07148914 chr20:33460835 GGT7 -0.37 -7.99 -0.3 6.25e-15 Glomerular filtration rate (creatinine); BRCA cis rs7072216 0.727 rs942809 chr10:100168001 G/A cg26618903 chr10:100175079 PYROXD2 -0.29 -8.58 -0.32 6.92e-17 Metabolite levels; BRCA cis rs7666738 0.830 rs11931166 chr4:99054187 A/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.660 rs2644295 chr7:2860217 A/C cg04166393 chr7:2884313 GNA12 0.39 8.45 0.32 1.96e-16 Height; BRCA cis rs7552404 0.924 rs2173378 chr1:76201992 G/T cg22875332 chr1:76189707 ACADM 0.66 15.78 0.53 1.35e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg14983838 chr19:29218262 NA 0.54 10.1 0.37 2.35e-22 Methadone dose in opioid dependence; BRCA cis rs460214 0.539 rs55819392 chr21:40038207 G/A cg21578987 chr21:40029669 ERG 0.36 8.32 0.31 5.33e-16 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs8170 0.603 rs11086068 chr19:17420165 T/C cg04749549 chr19:17459798 NA -0.36 -9.78 -0.36 3.75e-21 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs2072499 0.966 rs6427304 chr1:156156789 A/G cg25208724 chr1:156163844 SLC25A44 1.03 31.84 0.78 5.35e-134 Testicular germ cell tumor; BRCA cis rs6964587 1.000 rs6956596 chr7:91750107 T/G cg22117172 chr7:91764530 CYP51A1 0.23 7.84 0.3 1.9e-14 Breast cancer; BRCA cis rs17685 0.712 rs1859792 chr7:75789264 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.08 -0.3 3.2e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10883723 0.810 rs12265877 chr10:104247247 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.81 0.62 1.76e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs8141529 0.748 rs2064261 chr22:29287730 C/T cg02153584 chr22:29168773 CCDC117 0.51 10.74 0.39 7.34e-25 Lymphocyte counts; BRCA cis rs9811920 0.609 rs17174947 chr3:99598884 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg04267008 chr7:1944627 MAD1L1 -0.4 -8.79 -0.33 1.43e-17 Schizophrenia; BRCA trans rs7618501 0.933 rs3811695 chr3:49761613 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.42 -0.38 1.39e-23 Intelligence (multi-trait analysis); BRCA cis rs8062405 1.000 rs4788095 chr16:28831359 T/C cg16576597 chr16:28551801 NUPR1 0.3 8.42 0.32 2.52e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9287719 0.967 rs6709466 chr2:10748257 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs7264396 0.790 rs2425115 chr20:34322418 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -16.14 -0.54 2.07e-49 Total cholesterol levels; BRCA cis rs12973672 1.000 rs10414846 chr19:35772471 A/G cg12095397 chr19:35769544 USF2 -0.37 -8.29 -0.31 6.72e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7726839 1.000 rs7726839 chr5:618586 A/G cg09021430 chr5:549028 NA -0.52 -14.83 -0.51 5.54e-43 Obesity-related traits; BRCA cis rs758324 0.947 rs687816 chr5:131262077 C/T cg06307176 chr5:131281290 NA -0.53 -10.1 -0.37 2.4e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg12373951 chr3:133503437 NA 0.34 8.03 0.3 4.6e-15 Iron status biomarkers; BRCA cis rs9463078 0.547 rs764397 chr6:44710771 C/A cg25276700 chr6:44698697 NA 0.36 8.18 0.31 1.56e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9443645 0.901 rs9352667 chr6:79572296 A/G cg09184832 chr6:79620586 NA 0.52 11.54 0.42 4.23e-28 Intelligence (multi-trait analysis); BRCA cis rs1005277 0.579 rs1740732 chr10:38491385 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.33 -0.59 1.34e-60 Extrinsic epigenetic age acceleration; BRCA trans rs2204008 0.806 rs35534445 chr12:38279093 C/T cg06521331 chr12:34319734 NA -0.51 -9.43 -0.35 7.52e-20 Bladder cancer; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.54 -11.35 -0.41 2.41e-27 Lymphocyte counts; BRCA cis rs9467773 0.844 rs2393669 chr6:26503873 C/T cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.23e-60 Intelligence (multi-trait analysis); BRCA cis rs4803468 1.000 rs10422783 chr19:41906436 T/C cg09537434 chr19:41945824 ATP5SL -0.98 -23.41 -0.68 5.39e-88 Height; BRCA cis rs3733585 0.699 rs62294331 chr4:9959889 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs10782582 0.609 rs78748984 chr1:76340467 G/A cg10523679 chr1:76189770 ACADM -0.42 -8.05 -0.3 4.17e-15 Daytime sleep phenotypes; BRCA cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.77e-27 Uric acid levels; BRCA cis rs6089584 1.000 rs6089587 chr20:60564829 C/T cg13770153 chr20:60521292 NA -0.45 -10.81 -0.39 4.09e-25 Body mass index; BRCA cis rs3806843 0.735 rs2530242 chr5:140053351 G/C cg16179182 chr5:140090404 VTRNA1-1 0.47 10.99 0.4 7.61e-26 Depressive symptoms (multi-trait analysis); BRCA cis rs3845702 0.736 rs9288045 chr2:180814194 G/A cg01881094 chr2:180872142 CWC22 -1.03 -18.42 -0.59 4.48e-61 Schizophrenia; BRCA cis rs708547 0.581 rs10020462 chr4:57825593 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.42 8.21 0.31 1.25e-15 Response to bleomycin (chromatid breaks); BRCA cis rs8180040 0.764 rs4683324 chr3:47251284 T/C cg16586182 chr3:47516702 SCAP -0.56 -12.79 -0.45 1.59e-33 Colorectal cancer; BRCA cis rs798554 0.836 rs798502 chr7:2789880 G/T cg04166393 chr7:2884313 GNA12 -0.44 -8.52 -0.32 1.15e-16 Height; BRCA trans rs6479891 1.000 rs12416113 chr10:64896477 A/T cg14819942 chr15:35414228 NA 0.34 8.52 0.32 1.19e-16 Arthritis (juvenile idiopathic); BRCA cis rs2882667 0.858 rs11741150 chr5:138431457 C/T cg04439458 chr5:138467593 SIL1 -0.41 -10.18 -0.37 1.13e-22 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs796364 0.806 rs74266489 chr2:201005732 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.56 -0.35 2.58e-20 Schizophrenia; BRCA cis rs2108225 0.967 rs6979054 chr7:107447488 A/C cg18560240 chr7:107437656 SLC26A3 -0.53 -10.59 -0.39 2.87e-24 Ulcerative colitis; BRCA cis rs7246657 0.653 rs10406612 chr19:37716611 C/T cg14683738 chr19:37701593 ZNF585B 0.54 8.13 0.31 2.26e-15 Coronary artery calcification; BRCA cis rs77741769 0.571 rs869781 chr12:121340246 T/C cg02419362 chr12:121203948 SPPL3 0.34 7.96 0.3 7.83e-15 Mean corpuscular volume; BRCA cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.89 0.4 1.94e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35306767 0.714 rs7075188 chr10:1088746 G/T cg20503657 chr10:835505 NA -0.57 -10.44 -0.38 1.16e-23 Eosinophil percentage of granulocytes; BRCA cis rs17376456 0.542 rs35672980 chr5:93284877 A/T cg25358565 chr5:93447407 FAM172A -0.51 -9.36 -0.35 1.37e-19 Diabetic retinopathy; BRCA cis rs910316 0.967 rs175502 chr14:75533679 A/G cg11812906 chr14:75593930 NEK9 -0.63 -14.42 -0.5 4.98e-41 Height; BRCA trans rs7647973 0.710 rs1491983 chr3:49639803 G/T cg21659725 chr3:3221576 CRBN -0.47 -8.46 -0.32 1.86e-16 Menarche (age at onset); BRCA cis rs1451375 0.617 rs896307 chr7:50569060 T/C cg18232548 chr7:50535776 DDC -0.42 -9.06 -0.34 1.59e-18 Malaria; BRCA cis rs6088580 0.634 rs6059851 chr20:33047945 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.55 0.32 9.35e-17 Glomerular filtration rate (creatinine); BRCA trans rs61931739 0.500 rs10844734 chr12:34043083 G/A cg26384229 chr12:38710491 ALG10B 0.56 12.16 0.43 9.7e-31 Morning vs. evening chronotype; BRCA cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.59 0.35 2.01e-20 Eosinophil percentage of white cells; BRCA cis rs6815814 0.950 rs55830619 chr4:38807364 G/A cg02016764 chr4:38805732 TLR1 -0.6 -9.57 -0.35 2.39e-20 Breast cancer; BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.24 -0.41 7.23e-27 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs7395581 0.918 rs7124955 chr11:47315274 A/T cg25783544 chr11:47291846 MADD 0.4 9.03 0.34 1.97e-18 HDL cholesterol; BRCA cis rs4819052 0.819 rs34818688 chr21:46672416 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.88 0.48 1.77e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17601876 0.814 rs12050767 chr15:51557257 T/C cg19946085 chr15:51559439 CYP19A1 -0.38 -11.4 -0.41 1.55e-27 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6088580 0.634 rs6142153 chr20:32968747 C/G cg08999081 chr20:33150536 PIGU -0.44 -12.35 -0.44 1.37e-31 Glomerular filtration rate (creatinine); BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg01262667 chr19:19385393 TM6SF2 0.41 10.62 0.39 2.25e-24 Tonsillectomy; BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg22903471 chr2:27725779 GCKR -0.39 -9.72 -0.36 6.36e-21 Total body bone mineral density; BRCA cis rs9549367 0.789 rs34568744 chr13:113894564 G/T cg00898013 chr13:113819073 PROZ -0.37 -8.96 -0.33 3.61e-18 Platelet distribution width; BRCA cis rs2859741 0.967 rs535876 chr1:37484052 C/G cg09363841 chr1:37513479 NA -0.64 -16.09 -0.54 3.75e-49 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA trans rs7647973 0.626 rs2131108 chr3:49665390 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.9 -0.3 1.26e-14 Menarche (age at onset); BRCA cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg19812747 chr11:111475976 SIK2 -0.41 -7.95 -0.3 8.57e-15 Primary sclerosing cholangitis; BRCA cis rs2243480 1.000 rs387676 chr7:65598220 C/T cg18252515 chr7:66147081 NA -1.07 -15.67 -0.53 4.69e-47 Diabetic kidney disease; BRCA cis rs6088813 1.000 rs1406947 chr20:33969530 C/T cg14752227 chr20:34000481 UQCC -0.42 -8.93 -0.33 4.33e-18 Height; BRCA cis rs12791968 0.649 rs3802785 chr11:44995441 C/T cg11846598 chr11:44996168 LOC221122 -0.53 -9.15 -0.34 7.85e-19 Inhibitory control; BRCA cis rs7646881 0.953 rs73015657 chr3:158451932 G/A cg19483011 chr3:158453295 NA -0.49 -9.34 -0.35 1.61e-19 Tetralogy of Fallot; BRCA cis rs2070488 1.000 rs13074025 chr3:38455704 C/A cg24069376 chr3:38537580 EXOG 0.4 11.4 0.41 1.51e-27 Electrocardiographic conduction measures; BRCA cis rs11605924 0.934 rs7945565 chr11:45878992 A/G ch.11.939596F chr11:45881766 CRY2 -0.45 -10.16 -0.37 1.42e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2014572 0.967 rs8100154 chr19:57765432 A/G cg24459738 chr19:57751996 ZNF805 -0.37 -8.59 -0.32 6.39e-17 Hyperactive-impulsive symptoms; BRCA trans rs629535 0.814 rs614050 chr8:70065642 G/A cg21567404 chr3:27674614 NA 1.01 20.74 0.63 1.93e-73 Dupuytren's disease; BRCA cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg04553112 chr3:125709451 NA -0.54 -8.86 -0.33 8.18e-18 Blood pressure (smoking interaction); BRCA cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg01448562 chr3:133502909 NA -0.52 -11.02 -0.4 5.54e-26 Iron status biomarkers; BRCA cis rs73086581 1.000 rs73086597 chr20:3983571 G/A cg02187196 chr20:3869020 PANK2 0.52 9.36 0.35 1.37e-19 Response to antidepressants in depression; BRCA cis rs8062405 0.789 rs2106480 chr16:28537971 T/C cg16576597 chr16:28551801 NUPR1 0.28 7.93 0.3 9.92e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7267979 1.000 rs2257985 chr20:25269743 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17685 0.725 rs6947068 chr7:75662056 T/C cg16489192 chr7:75678113 MDH2;STYXL1 0.38 8.3 0.31 6.33e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2066819 1.000 rs41363748 chr12:56696056 C/T cg26714650 chr12:56694279 CS 1.0 13.94 0.48 9.08e-39 Psoriasis vulgaris; BRCA cis rs9287719 0.934 rs6710033 chr2:10757677 C/T cg00105475 chr2:10696890 NA 0.44 10.29 0.38 4.38e-23 Prostate cancer; BRCA trans rs11098499 0.863 rs3822194 chr4:120471648 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs3772130 0.583 rs28497949 chr3:121448675 T/A cg20356878 chr3:121714668 ILDR1 0.37 8.32 0.31 5.23e-16 Cognitive performance; BRCA cis rs1008375 1.000 rs10805359 chr4:17684886 A/G cg15017067 chr4:17643749 FAM184B 0.32 9.63 0.36 1.43e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg02659138 chr7:134003124 SLC35B4 -0.4 -12.05 -0.43 2.72e-30 Mean platelet volume; BRCA cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.11 0.46 5.78e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.78 0.33 1.53e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs694739 0.734 rs663743 chr11:64107735 G/A cg02228329 chr11:64053129 BAD;GPR137 0.48 9.58 0.35 2.11e-20 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 10.95 0.4 1.11e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs11039798 0.623 rs6485879 chr11:48587984 G/T cg03929089 chr4:120376271 NA 0.49 8.21 0.31 1.24e-15 Axial length; BRCA cis rs2404602 0.735 rs11629888 chr15:76719880 A/T cg23625390 chr15:77176239 SCAPER -0.52 -12.1 -0.43 1.76e-30 Blood metabolite levels; BRCA cis rs250677 0.522 rs56309414 chr5:148376026 C/G cg12140854 chr5:148520817 ABLIM3 -0.41 -8.19 -0.31 1.38e-15 Breast cancer; BRCA cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs6484504 0.652 rs674035 chr11:31399014 G/A cg26647111 chr11:31128758 NA 0.46 9.89 0.36 1.54e-21 Red blood cell count; BRCA cis rs6120849 1.000 rs6120849 chr20:33730387 C/T cg24642439 chr20:33292090 TP53INP2 0.54 9.36 0.35 1.29e-19 Protein C levels; BRCA cis rs6570726 0.846 rs6570700 chr6:145931552 A/G cg23711669 chr6:146136114 FBXO30 0.71 17.07 0.56 4.4e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 0.782 rs8113006 chr19:19669441 C/G cg11584989 chr19:19387371 SF4 -0.49 -9.99 -0.37 6.24e-22 Bipolar disorder; BRCA cis rs709400 0.628 rs12879085 chr14:103874420 G/A cg12935359 chr14:103987150 CKB 0.58 14.02 0.48 3.98e-39 Body mass index; BRCA cis rs2580764 0.624 rs12713284 chr2:55228861 G/A cg09592903 chr2:55203963 RTN4 -0.41 -10.35 -0.38 2.69e-23 Mean platelet volume; BRCA cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.77 -0.36 4.25e-21 Alcohol dependence; BRCA cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.76 -0.42 5.03e-29 Bipolar disorder; BRCA cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg17724175 chr1:150552817 MCL1 0.25 8.13 0.31 2.19e-15 Tonsillectomy; BRCA cis rs367615 0.704 rs7704824 chr5:108850278 A/G cg17395555 chr5:108820864 NA 0.34 10.69 0.39 1.18e-24 Colorectal cancer (SNP x SNP interaction); BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg22907277 chr7:1156413 C7orf50 0.59 9.1 0.34 1.11e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10267417 0.603 rs10081258 chr7:19934237 C/G cg05791153 chr7:19748676 TWISTNB 0.43 8.09 0.3 3.01e-15 Night sleep phenotypes; BRCA cis rs953387 0.910 rs16833170 chr2:136929076 A/G cg05194412 chr2:137003533 NA -0.34 -7.98 -0.3 6.88e-15 Arthritis (juvenile idiopathic); BRCA cis rs6484504 0.532 rs11031332 chr11:31278962 T/C cg26647111 chr11:31128758 NA -0.44 -9.71 -0.36 6.96e-21 Red blood cell count; BRCA cis rs17604090 0.878 rs10262227 chr7:29704073 G/A cg19413766 chr7:29689036 LOC646762 -0.61 -8.23 -0.31 1.07e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs2645694 0.603 rs2703123 chr4:77821154 C/T cg10057126 chr4:77819792 ANKRD56 0.68 15.42 0.52 7.78e-46 Emphysema distribution in smoking; BRCA cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg10802521 chr3:52805072 NEK4 -0.31 -8.44 -0.32 2.17e-16 Electroencephalogram traits; BRCA cis rs76419734 0.510 rs28450989 chr4:106630007 G/C cg24545054 chr4:106630052 GSTCD;INTS12 0.57 12.5 0.44 3.21e-32 Post bronchodilator FEV1; BRCA cis rs7727544 0.684 rs272889 chr5:131665378 A/G cg07395648 chr5:131743802 NA -0.39 -9.71 -0.36 7.05e-21 Blood metabolite levels; BRCA trans rs1997103 1.000 rs6948112 chr7:55411302 G/A cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs758324 0.947 rs7725924 chr5:131118165 C/G cg06307176 chr5:131281290 NA 0.53 10.21 0.37 8.75e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg24130564 chr14:104152367 KLC1 -0.41 -8.78 -0.33 1.52e-17 Reticulocyte count; BRCA cis rs1018836 0.923 rs13277387 chr8:91633713 C/G cg16814680 chr8:91681699 NA -0.5 -10.52 -0.38 5.61e-24 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg11247378 chr22:39784982 NA -0.62 -14.22 -0.49 4.45e-40 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs9929218 1.000 rs9928847 chr16:68797893 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -13.82 -0.48 3.34e-38 Colorectal cancer; BRCA cis rs1865721 1.000 rs17284077 chr18:73204128 C/T cg26385618 chr18:73139727 C18orf62 -0.38 -8.63 -0.32 4.7e-17 Intelligence; BRCA cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg25019033 chr10:957182 NA -0.42 -8.05 -0.3 4.14e-15 Eosinophil percentage of granulocytes; BRCA cis rs6684514 1.000 rs12117951 chr1:156305286 G/A cg16558208 chr1:156270281 VHLL 0.37 8.32 0.31 5.29e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg18479299 chr3:125709523 NA -0.54 -8.33 -0.31 4.84e-16 Blood pressure (smoking interaction); BRCA trans rs800082 0.668 rs6805395 chr3:144292116 T/C cg24215973 chr2:240111563 HDAC4 -0.43 -10.32 -0.38 3.26e-23 Smoking behavior; BRCA cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg20476274 chr7:133979776 SLC35B4 0.7 21.39 0.65 5.77e-77 Mean platelet volume; BRCA cis rs9486719 1.000 rs1303852 chr6:96864523 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.97 0.46 2.61e-34 Migraine;Coronary artery disease; BRCA cis rs17253792 0.908 rs74354306 chr14:56065778 T/G cg01858014 chr14:56050164 KTN1 -0.77 -10.93 -0.4 1.3e-25 Putamen volume; BRCA cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs2108225 0.934 rs2301988 chr7:107443833 A/G cg18560240 chr7:107437656 SLC26A3 0.53 11.16 0.4 1.49e-26 Ulcerative colitis; BRCA cis rs10876993 0.928 rs1689595 chr12:58056763 C/T cg18357645 chr12:58087776 OS9 0.45 13.22 0.46 1.89e-35 Celiac disease or Rheumatoid arthritis; BRCA cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg08917208 chr2:24149416 ATAD2B 0.52 8.28 0.31 7.42e-16 Asthma; BRCA cis rs10501293 1.000 rs10768913 chr11:43060750 T/C cg03447554 chr11:43094025 NA 0.5 9.15 0.34 7.78e-19 Cognitive performance; BRCA cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg24069376 chr3:38537580 EXOG 0.33 9.18 0.34 6.07e-19 Electrocardiographic conduction measures; BRCA trans rs1997103 1.000 rs6949222 chr7:55411264 C/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs35306767 0.671 rs11253473 chr10:906826 A/G cg25019033 chr10:957182 NA -0.41 -7.9 -0.3 1.23e-14 Eosinophil percentage of granulocytes; BRCA cis rs4566357 0.615 rs10184991 chr2:227916533 G/A cg05526886 chr2:227700861 RHBDD1 -0.4 -8.23 -0.31 1.06e-15 Coronary artery disease; BRCA cis rs1568889 1.000 rs10767693 chr11:28093926 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.25 0.63 7.91e-71 Bipolar disorder; BRCA cis rs2901460 0.509 rs10165560 chr2:62059398 A/C cg02183531 chr2:62113199 CCT4 -0.44 -8.62 -0.32 5.3e-17 Mean corpuscular volume; BRCA cis rs7089973 0.604 rs11819372 chr10:116594934 A/G cg23260525 chr10:116636907 FAM160B1 0.3 8.03 0.3 4.75e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs3818285 0.632 rs536343 chr10:111632879 T/C cg00817464 chr10:111662876 XPNPEP1 0.45 14.64 0.5 4.8e-42 Superior crus of antihelix expression; BRCA cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg04546413 chr19:29218101 NA 0.64 12.33 0.44 1.75e-31 Methadone dose in opioid dependence; BRCA cis rs9291683 0.546 rs7442336 chr4:10045783 G/A cg11266682 chr4:10021025 SLC2A9 0.45 12.02 0.43 3.9e-30 Bone mineral density; BRCA cis rs921968 0.528 rs13382651 chr2:219628191 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.97e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs67340775 0.541 rs200968 chr6:27859568 T/C cg26587870 chr6:27730563 NA -0.45 -8.09 -0.3 3.07e-15 Lung cancer in ever smokers; BRCA cis rs875971 0.522 rs781144 chr7:65440344 C/G cg18876405 chr7:65276391 NA 0.68 17.94 0.58 1.33e-58 Aortic root size; BRCA cis rs7666738 0.830 rs28594127 chr4:99001121 T/G cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs17253792 0.822 rs75663029 chr14:56092385 T/C cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA trans rs6076960 0.811 rs6053960 chr20:6176778 T/C cg21095983 chr6:86352623 SYNCRIP 0.42 10.07 0.37 3.11e-22 Smooth-surface caries; BRCA cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg01579765 chr21:45077557 HSF2BP -0.38 -10.13 -0.37 1.86e-22 Mean corpuscular volume; BRCA cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg24642439 chr20:33292090 TP53INP2 -0.53 -11.58 -0.42 2.73e-28 Glomerular filtration rate (creatinine); BRCA cis rs17818399 0.708 rs1531133 chr2:46843631 A/G cg02822958 chr2:46747628 ATP6V1E2 0.47 9.63 0.36 1.36e-20 Height; BRCA cis rs7552404 1.000 rs7548962 chr1:76139266 G/A cg10523679 chr1:76189770 ACADM 0.76 15.88 0.53 4.12e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17345786 0.520 rs13062677 chr3:101305078 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.36 8.36 0.31 4.07e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.747 rs2339491 chr1:152985322 T/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.15 -0.34 7.8e-19 Inflammatory skin disease; BRCA cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.68 16.02 0.54 8.33e-49 Axial length; BRCA cis rs7618501 0.633 rs6446193 chr3:50059758 T/C cg05623727 chr3:50126028 RBM5 -0.42 -10.07 -0.37 3.2e-22 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs4596713 0.538 rs4421408 chr9:71760884 G/T cg16512924 chr15:28394682 HERC2 0.44 10.38 0.38 2.06e-23 Headache; BRCA cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg18351406 chr4:77819688 ANKRD56 -0.58 -13.08 -0.46 8.63e-35 Emphysema distribution in smoking; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg24642844 chr7:1081250 C7orf50 -0.9 -16.23 -0.54 7.52e-50 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7100689 0.598 rs2342815 chr10:82086532 T/C cg01528321 chr10:82214614 TSPAN14 0.81 17.21 0.56 8.09e-55 Post bronchodilator FEV1; BRCA cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg22974920 chr21:40686053 BRWD1 -0.38 -8.7 -0.33 2.86e-17 Cognitive function; BRCA trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.2 18.89 0.6 1.41e-63 Hemostatic factors and hematological phenotypes; BRCA trans rs9397585 0.599 rs685826 chr6:153411255 C/T cg15216925 chr5:179921655 CNOT6 0.48 8.86 0.33 8.09e-18 Body mass index; BRCA cis rs9649465 0.806 rs6971297 chr7:123293342 A/T cg04330084 chr7:123175371 IQUB -0.3 -8.21 -0.31 1.25e-15 Migraine; BRCA cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg00825309 chr19:58991885 ZNF446 -0.58 -12.78 -0.45 1.83e-33 Uric acid clearance; BRCA cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg14061069 chr19:46274453 DMPK 0.63 17.68 0.57 3.04e-57 Coronary artery disease; BRCA cis rs4780401 0.609 rs12927966 chr16:11814562 C/T cg01061890 chr16:11836724 TXNDC11 -0.57 -13.35 -0.47 5.15e-36 Rheumatoid arthritis; BRCA trans rs61931739 0.517 rs2636074 chr12:34064056 C/T cg26384229 chr12:38710491 ALG10B 0.52 11.18 0.4 1.28e-26 Morning vs. evening chronotype; BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg22920501 chr2:26401640 FAM59B 0.83 13.58 0.47 4.15e-37 Gut microbiome composition (summer); BRCA cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg03433033 chr1:76189801 ACADM 0.74 18.97 0.6 5.66e-64 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6912958 0.667 rs7746545 chr6:88090225 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.3 7.98 0.3 6.85e-15 Monocyte percentage of white cells; BRCA cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg11764359 chr7:65958608 NA 0.63 10.76 0.39 6.35e-25 Aortic root size; BRCA cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.25 -0.44 3.84e-31 Developmental language disorder (linguistic errors); BRCA cis rs12579753 0.917 rs11115032 chr12:82205073 T/C cg07988820 chr12:82153109 PPFIA2 -0.5 -8.77 -0.33 1.58e-17 Resting heart rate; BRCA cis rs929596 0.785 rs6714634 chr2:234664765 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.47 12.21 0.43 5.72e-31 Total bilirubin levels in HIV-1 infection; BRCA cis rs1003719 0.788 rs2251161 chr21:38467857 C/G cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.12 0.49 1.31e-39 Eye color traits; BRCA cis rs9487051 0.768 rs435611 chr6:109527755 C/T cg01475377 chr6:109611718 NA -0.42 -10.48 -0.38 7.98e-24 Reticulocyte fraction of red cells; BRCA cis rs7617773 0.780 rs34630841 chr3:48343261 G/A cg11946769 chr3:48343235 NME6 0.7 14.01 0.48 4.4e-39 Coronary artery disease; BRCA cis rs1008375 0.931 rs6449328 chr4:17700474 C/T cg16339924 chr4:17578868 LAP3 0.57 13.77 0.48 5.56e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg02297831 chr4:17616191 MED28 0.37 8.72 0.33 2.44e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11992162 1.000 rs7460395 chr8:11835375 C/T cg15556689 chr8:8085844 FLJ10661 0.33 8.25 0.31 9.01e-16 Monocyte count; BRCA cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg24829409 chr8:58192753 C8orf71 -0.58 -11.96 -0.43 6.52e-30 Developmental language disorder (linguistic errors); BRCA cis rs4478137 0.899 rs10857354 chr4:164239841 A/G cg06758707 chr4:164254230 NPY1R 0.57 12.45 0.44 5.39e-32 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs6912958 0.781 rs7742965 chr6:88278196 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs1020064 0.636 rs1529975 chr2:105929901 T/C cg02079111 chr2:105885981 TGFBRAP1 0.44 8.43 0.32 2.31e-16 AIDS; BRCA cis rs1371614 0.635 rs12714002 chr2:27134925 C/T cg12368169 chr2:27073192 DPYSL5 -0.3 -8.71 -0.33 2.68e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9467773 1.000 rs1321480 chr6:26532742 A/G cg11502198 chr6:26597334 ABT1 0.47 9.37 0.35 1.25e-19 Intelligence (multi-trait analysis); BRCA trans rs11039798 0.588 rs11039782 chr11:48524785 A/G cg15704280 chr7:45808275 SEPT13 0.54 9.13 0.34 8.85e-19 Axial length; BRCA cis rs9341808 0.718 rs9448899 chr6:80845864 G/A cg08355045 chr6:80787529 NA 0.37 9.44 0.35 6.69e-20 Sitting height ratio; BRCA cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg11764359 chr7:65958608 NA -0.79 -19.31 -0.61 8.33e-66 Aortic root size; BRCA cis rs4363385 0.747 rs2225919 chr1:152969603 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.85 -0.36 2.13e-21 Inflammatory skin disease; BRCA cis rs11626933 0.851 rs2282031 chr14:90730943 A/G cg14092571 chr14:90743983 NA -0.66 -17.78 -0.58 9.31e-58 Gut microbiota (bacterial taxa); BRCA cis rs4077515 0.577 rs10870165 chr9:139316601 C/T cg14169450 chr9:139327907 INPP5E 0.41 9.46 0.35 5.92e-20 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs561341 1.000 rs527256 chr17:30321293 C/G cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.58e-17 Hip circumference adjusted for BMI; BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs7178424 0.742 rs1981916 chr15:62171479 T/C cg00456672 chr15:62358751 C2CD4A -0.38 -8.93 -0.33 4.64e-18 Height; BRCA cis rs2637030 0.501 rs375956 chr5:52883715 C/G cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs6570726 0.935 rs9390329 chr6:145828026 T/C cg23711669 chr6:146136114 FBXO30 0.65 15.41 0.52 8.21e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.738 rs28687057 chr4:120280812 A/G cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs477692 0.544 rs7894836 chr10:131442595 T/A cg05714579 chr10:131428358 MGMT -0.72 -16.77 -0.55 1.38e-52 Response to temozolomide; BRCA cis rs1577917 1.000 rs791856 chr6:86681841 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 11.93 0.43 9.43e-30 Response to antipsychotic treatment; BRCA cis rs2191566 1.000 rs2356549 chr19:44511202 A/T cg20607764 chr19:44506953 ZNF230 -0.42 -9.5 -0.35 4e-20 Acute lymphoblastic leukemia (childhood); BRCA cis rs644148 0.785 rs117048220 chr19:44965555 G/A cg15540054 chr19:45004280 ZNF180 0.56 11.6 0.42 2.2e-28 Personality dimensions; BRCA cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.1 0.4 2.64e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs4073582 0.595 rs708471 chr11:65931008 A/G cg16950941 chr11:66035639 RAB1B 0.44 11.97 0.43 6.29e-30 Gout; BRCA trans rs61931739 0.500 rs11053261 chr12:34530810 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.46 0.55 4.99e-51 Morning vs. evening chronotype; BRCA cis rs1865721 0.804 rs719179 chr18:73146396 A/G cg26385618 chr18:73139727 C18orf62 -0.45 -10.82 -0.39 3.68e-25 Intelligence; BRCA trans rs2797160 1.000 rs13328298 chr6:126016580 G/A cg05039488 chr6:79577232 IRAK1BP1 0.35 7.88 0.3 1.4e-14 Endometrial cancer; BRCA cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg13319975 chr6:146136371 FBXO30 0.42 9.65 0.36 1.19e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs10540 0.908 rs1044707 chr11:491334 G/T cg21784768 chr11:537496 LRRC56 0.65 8.46 0.32 1.87e-16 Body mass index; BRCA cis rs7903847 0.642 rs7078004 chr10:99140511 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.64 -0.32 4.5e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10046574 0.731 rs10267977 chr7:135159392 G/A cg27474649 chr7:135195673 CNOT4 0.61 8.89 0.33 6.04e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs35491132 1 rs35491132 chr6:27527227 GT/G cg01620082 chr3:125678407 NA -0.84 -9.71 -0.36 7.09e-21 Urinary tract infection frequency; BRCA cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg12386194 chr3:101231763 SENP7 0.59 11.88 0.43 1.54e-29 Colonoscopy-negative controls vs population controls; BRCA trans rs7618501 1.000 rs2271961 chr3:49878113 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.74 -0.65 6.96e-79 Intelligence (multi-trait analysis); BRCA cis rs911555 0.755 rs55742283 chr14:103942965 A/G cg24130564 chr14:104152367 KLC1 0.35 7.98 0.3 6.97e-15 Intelligence (multi-trait analysis); BRCA cis rs9325144 0.505 rs7955162 chr12:38711658 G/A cg13010199 chr12:38710504 ALG10B 0.46 11.29 0.41 4.41e-27 Morning vs. evening chronotype; BRCA cis rs2625529 0.824 rs4776586 chr15:72430503 C/A cg16672083 chr15:72433130 SENP8 -0.85 -17.91 -0.58 1.94e-58 Red blood cell count; BRCA cis rs7772486 0.875 rs1929523 chr6:146339989 T/A cg13319975 chr6:146136371 FBXO30 -0.36 -8.3 -0.31 6.2e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs6582630 0.502 rs11514371 chr12:38306306 G/C cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs6942756 0.774 rs2402944 chr7:128951402 G/T cg02491457 chr7:128862824 NA -0.56 -12.01 -0.43 4.11e-30 White matter hyperintensity burden; BRCA cis rs17095355 1.000 rs12263915 chr10:111744664 G/C cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.64 -0.36 1.26e-20 Biliary atresia; BRCA cis rs4285028 0.948 rs13067270 chr3:121673901 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs2463822 1.000 rs2513076 chr11:62103711 A/G cg06239285 chr11:62104954 ASRGL1 0.68 11.2 0.41 1.03e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs4919694 1.000 rs10509760 chr10:104634107 A/G cg04362960 chr10:104952993 NT5C2 0.88 14.07 0.49 2.25e-39 Arsenic metabolism; BRCA cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg06046430 chr4:77819534 ANKRD56 0.58 12.65 0.45 6.89e-33 Emphysema distribution in smoking; BRCA cis rs910316 0.763 rs175042 chr14:75470833 A/T cg11812906 chr14:75593930 NEK9 -0.61 -14.2 -0.49 5.8e-40 Height; BRCA cis rs651907 0.535 rs13084113 chr3:101534039 C/G cg12386194 chr3:101231763 SENP7 0.46 9.76 0.36 4.64e-21 Colorectal cancer; BRCA cis rs7020830 0.898 rs997318 chr9:37364094 C/T cg14294708 chr9:37120828 ZCCHC7 1.13 36.57 0.82 8.6e-159 Schizophrenia; BRCA cis rs7267979 1.000 rs6050559 chr20:25329915 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.94 0.33 4.2e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs490234 0.676 rs4838263 chr9:128225199 G/A cg14078157 chr9:128172775 NA -0.5 -11.12 -0.4 2.15e-26 Mean arterial pressure; BRCA cis rs66887589 0.592 rs28580295 chr4:120278873 C/T cg09307838 chr4:120376055 NA 0.5 10.84 0.39 2.97e-25 Diastolic blood pressure; BRCA cis rs112217694 1.000 rs17196218 chr4:104658371 C/T cg04535008 chr4:104641033 TACR3 -0.82 -8.78 -0.33 1.49e-17 Menarche (age at onset); BRCA cis rs60843830 1.000 rs55946380 chr2:268293 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.72 0.6 1.16e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs3820928 1.000 rs3731593 chr2:227773924 A/G cg11843606 chr2:227700838 RHBDD1 -0.41 -8.92 -0.33 5.06e-18 Pulmonary function; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg02951883 chr7:2050386 MAD1L1 0.61 15.79 0.53 1.15e-47 Bipolar disorder and schizophrenia; BRCA cis rs7246657 0.943 rs10403613 chr19:37844306 C/T cg18154014 chr19:37997991 ZNF793 0.61 11.39 0.41 1.69e-27 Coronary artery calcification; BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg26314531 chr2:26401878 FAM59B -0.65 -11.17 -0.4 1.42e-26 Gut microbiome composition (summer); BRCA cis rs6963495 0.818 rs6955796 chr7:105170321 T/G cg19920283 chr7:105172520 RINT1 0.59 9.53 0.35 3.29e-20 Bipolar disorder (body mass index interaction); BRCA trans rs6582630 0.519 rs7305570 chr12:38349285 G/A cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 9.43e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs883565 0.718 rs1112438 chr3:39152345 G/A cg26331595 chr3:39149181 GORASP1;TTC21A 0.39 8.46 0.32 1.84e-16 Handedness; BRCA cis rs2839186 0.647 rs9976233 chr21:47616913 G/A cg12379764 chr21:47803548 PCNT 0.4 8.86 0.33 7.77e-18 Testicular germ cell tumor; BRCA cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1868673 0.965 rs6792759 chr3:150138424 C/T cg04908077 chr3:150187338 NA -0.33 -8.73 -0.33 2.22e-17 Waist circumference; BRCA cis rs7666738 0.830 rs13138063 chr4:99050438 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.38 0.57 1.03e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.875 rs1331640 chr6:146427250 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.73 -0.33 2.24e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs6785206 0.527 rs9844706 chr3:128380781 G/A cg16766828 chr3:128327626 NA -0.67 -10.84 -0.39 2.97e-25 Lymphocyte percentage of white cells; BRCA cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg25173405 chr17:45401733 C17orf57 0.54 11.83 0.42 2.41e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg13628971 chr7:2884303 GNA12 0.49 9.9 0.36 1.3e-21 Height; BRCA cis rs953387 0.744 rs115224560 chr2:136896041 T/A cg05194412 chr2:137003533 NA -0.38 -8.79 -0.33 1.4e-17 Arthritis (juvenile idiopathic); BRCA cis rs6430585 0.583 rs79176913 chr2:136638113 C/A cg07169764 chr2:136633963 MCM6 1.29 29.44 0.76 5.11e-121 Corneal structure; BRCA cis rs10851411 0.697 rs62019315 chr15:42863542 G/C cg21293051 chr15:42870591 STARD9 0.51 8.77 0.33 1.58e-17 Glucose homeostasis traits; BRCA trans rs208520 0.690 rs1563929 chr6:66702108 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.96 20.3 0.63 4.18e-71 Exhaled nitric oxide output; BRCA cis rs1113500 0.730 rs1777456 chr1:108588472 G/A cg06207961 chr1:108661230 NA -0.33 -7.81 -0.3 2.33e-14 Growth-regulated protein alpha levels; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg21248554 chr2:27665150 KRTCAP3 -0.36 -9.36 -0.35 1.38e-19 Total body bone mineral density; BRCA cis rs6484504 0.532 rs7121949 chr11:31288160 G/T cg14844989 chr11:31128820 NA -0.45 -9.56 -0.35 2.5e-20 Red blood cell count; BRCA cis rs7772486 0.764 rs9399569 chr6:146242942 C/T cg23711669 chr6:146136114 FBXO30 -0.68 -15.92 -0.53 2.69e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.53 -0.32 1.1e-16 Monocyte percentage of white cells; BRCA cis rs7945718 0.934 rs3993110 chr11:12794530 A/C cg25843174 chr11:12811716 TEAD1 0.23 8.68 0.32 3.34e-17 Educational attainment (years of education); BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg19010396 chr19:19431384 KIAA0892;SF4 0.48 9.6 0.35 1.8e-20 Tonsillectomy; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg22963979 chr7:1858916 MAD1L1 -0.44 -9.22 -0.34 4.16e-19 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.28e-18 Motion sickness; BRCA cis rs11098499 0.691 rs9996644 chr4:120238877 G/T cg09307838 chr4:120376055 NA 0.63 13.64 0.47 2.32e-37 Corneal astigmatism; BRCA cis rs7618501 0.699 rs6446187 chr3:49907111 C/A cg24110177 chr3:50126178 RBM5 -0.37 -9.94 -0.37 9.84e-22 Intelligence (multi-trait analysis); BRCA cis rs796364 0.760 rs1569178 chr2:201024512 T/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -9.06 -0.34 1.57e-18 Schizophrenia; BRCA cis rs9467773 1.000 rs6932156 chr6:26571506 T/G cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.53e-57 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg19723775 chr5:179050963 HNRNPH1 0.47 10.86 0.39 2.54e-25 Lung cancer; BRCA trans rs853679 0.607 rs67040724 chr6:27905509 T/C cg06606381 chr12:133084897 FBRSL1 -0.89 -8.97 -0.33 3.19e-18 Depression; BRCA cis rs778371 0.723 rs12619195 chr2:233678326 G/A cg08000102 chr2:233561755 GIGYF2 -0.85 -21.05 -0.64 3.94e-75 Schizophrenia; BRCA cis rs909002 0.830 rs10914461 chr1:32113217 G/A cg01639898 chr1:32083012 HCRTR1 0.3 8.95 0.33 3.82e-18 Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.68 0.53 3.95e-47 Platelet count; BRCA cis rs4566357 0.576 rs3769644 chr2:227917240 C/G cg05526886 chr2:227700861 RHBDD1 -0.4 -8.23 -0.31 1.06e-15 Coronary artery disease; BRCA cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg20203395 chr5:56204925 C5orf35 0.41 9.17 0.34 6.66e-19 Initial pursuit acceleration; BRCA cis rs2882667 0.690 rs4835706 chr5:138164726 G/A cg04439458 chr5:138467593 SIL1 0.31 7.81 0.3 2.28e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg12311346 chr5:56204834 C5orf35 0.62 13.08 0.46 8.22e-35 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11711311 1.000 rs16861312 chr3:113492402 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -9.51 -0.35 3.93e-20 IgG glycosylation; BRCA cis rs9914988 0.887 rs28873200 chr17:27149512 A/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.77 -0.33 1.66e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs11098499 0.863 rs34868248 chr4:120442430 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.48e-16 Corneal astigmatism; BRCA cis rs965469 1.000 rs2281500 chr20:3262824 C/T cg25506879 chr20:3388711 C20orf194 -0.52 -10.27 -0.38 5.09e-23 IFN-related cytopenia; BRCA cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.24 -0.34 3.68e-19 Bipolar disorder; BRCA cis rs9790314 0.715 rs980975 chr3:160771410 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -8.78 -0.33 1.5e-17 Morning vs. evening chronotype; BRCA trans rs10242455 0.702 rs17854665 chr7:99050039 G/A cg09045935 chr12:6379348 NA 0.83 8.28 0.31 7.06e-16 Blood metabolite levels; BRCA cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg14004847 chr7:1930337 MAD1L1 -0.4 -8.33 -0.31 5.01e-16 Schizophrenia; BRCA cis rs858239 1.000 rs156421 chr7:23312487 A/G cg23682824 chr7:23144976 KLHL7 0.35 8.92 0.33 4.7e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg14530993 chr4:882597 GAK 0.6 9.81 0.36 3.02e-21 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.931 rs10939733 chr4:17570658 T/C cg16339924 chr4:17578868 LAP3 0.66 16.3 0.54 3.13e-50 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs801193 0.844 rs2244022 chr7:66202430 A/G cg11764359 chr7:65958608 NA 0.62 13.54 0.47 6.51e-37 Aortic root size; BRCA cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.56 12.19 0.43 6.71e-31 Chronic sinus infection; BRCA cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.98 0.56 1.21e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs1005277 0.579 rs1614236 chr10:38502996 C/T cg23533926 chr12:111358616 MYL2 -0.42 -8.71 -0.33 2.6e-17 Extrinsic epigenetic age acceleration; BRCA trans rs3857536 0.813 rs1891600 chr6:66941645 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs11792861 0.888 rs72607168 chr9:111832192 G/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.24 0.31 1.01e-15 Menarche (age at onset); BRCA cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg00684032 chr4:1343700 KIAA1530 0.48 11.43 0.41 1.18e-27 Obesity-related traits; BRCA cis rs13418410 0.539 rs1545399 chr2:33843801 A/G cg04131969 chr2:33951647 MYADML -0.56 -10.94 -0.4 1.17e-25 Non-response to antidepressants and depression; BRCA cis rs1635 0.655 rs73742535 chr6:28302925 G/A cg15743358 chr6:28303923 ZNF323 -0.75 -8.56 -0.32 8.52e-17 Schizophrenia; BRCA trans rs3942852 0.774 rs11039519 chr11:48130094 G/C cg15704280 chr7:45808275 SEPT13 -0.48 -9.28 -0.34 2.58e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs1008375 0.931 rs6449309 chr4:17573208 C/T cg04450456 chr4:17643702 FAM184B 0.4 10.87 0.39 2.36e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg13880726 chr7:1868755 MAD1L1 0.5 9.79 0.36 3.55e-21 Bipolar disorder and schizophrenia; BRCA cis rs10751667 0.666 rs11246358 chr11:967349 G/A cg01483505 chr11:975446 AP2A2 0.3 8.1 0.31 2.72e-15 Alzheimer's disease (late onset); BRCA trans rs12310956 0.510 rs11052882 chr12:33890017 T/C cg26384229 chr12:38710491 ALG10B 0.41 9.44 0.35 6.6e-20 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg11062466 chr8:58055876 NA 0.5 8.88 0.33 6.54e-18 Developmental language disorder (linguistic errors); BRCA cis rs470119 1.000 rs470119 chr22:50966914 C/T cg12969734 chr22:50962224 SCO2 -0.38 -9.24 -0.34 3.56e-19 Mean corpuscular hemoglobin; BRCA cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg13319975 chr6:146136371 FBXO30 -0.6 -13.45 -0.47 1.66e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs36051895 0.659 rs3780366 chr9:5068596 T/C cg02405213 chr9:5042618 JAK2 -0.5 -8.99 -0.34 2.79e-18 Pediatric autoimmune diseases; BRCA cis rs7560272 0.538 rs1806683 chr2:73939812 C/T cg20560298 chr2:73613845 ALMS1 -0.33 -8.46 -0.32 1.88e-16 Schizophrenia; BRCA cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg23711669 chr6:146136114 FBXO30 0.75 17.25 0.56 4.8e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs8180040 0.966 rs11707895 chr3:47574937 G/A cg16586182 chr3:47516702 SCAP 0.64 13.93 0.48 1.04e-38 Colorectal cancer; BRCA cis rs736408 0.540 rs4687637 chr3:52634092 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.26 0.41 5.88e-27 Bipolar disorder; BRCA cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg07395648 chr5:131743802 NA 0.39 8.31 0.31 5.75e-16 Breast cancer; BRCA cis rs6598955 0.585 rs6659822 chr1:26626408 C/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.33 -0.31 4.98e-16 Obesity-related traits; BRCA cis rs11585357 1.000 rs72646785 chr1:17603472 G/T cg19159961 chr1:17633534 PADI4 0.56 8.7 0.33 2.8e-17 Hair shape; BRCA cis rs7098414 0.511 rs10887826 chr10:82151380 C/T cg00277334 chr10:82204260 NA -0.49 -10.46 -0.38 9.98e-24 Post bronchodilator FEV1; BRCA cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg02733842 chr7:1102375 C7orf50 -0.48 -9.65 -0.36 1.18e-20 Bronchopulmonary dysplasia; BRCA cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg22105103 chr4:187893119 NA 0.41 13.28 0.47 1.05e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs2243480 1.000 rs781149 chr7:65481284 C/T cg18252515 chr7:66147081 NA -0.84 -12.26 -0.44 3.6e-31 Diabetic kidney disease; BRCA cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg16586182 chr3:47516702 SCAP -0.55 -12.36 -0.44 1.33e-31 Colorectal cancer; BRCA cis rs13040088 0.580 rs11905041 chr20:61563408 C/T cg23096297 chr20:61557774 DIDO1 0.68 14.37 0.49 9.35e-41 Menopause (age at onset); BRCA cis rs17270561 0.609 rs12529272 chr6:25731342 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs921968 0.591 rs6717107 chr2:219588697 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.94e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9814567 0.964 rs9841180 chr3:134191880 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -18.07 -0.58 2.78e-59 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.07e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 1.000 rs6963646 chr7:65685767 T/C cg18876405 chr7:65276391 NA -0.56 -13.53 -0.47 7.6e-37 Aortic root size; BRCA cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.11 0.31 2.59e-15 Menopause (age at onset); BRCA cis rs17685 0.633 rs3801471 chr7:75696188 T/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.42 -0.32 2.49e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs17401966 0.597 rs11121555 chr1:10442856 C/T cg03954927 chr1:10346856 KIF1B 0.37 11.02 0.4 5.53e-26 Hepatocellular carcinoma; BRCA cis rs7904368 0.806 rs7087360 chr10:16872337 C/A cg23933602 chr10:16859644 RSU1 0.56 9.13 0.34 8.73e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.06 0.34 1.57e-18 Lymphocyte counts; BRCA cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg21535247 chr6:8435926 SLC35B3 0.38 8.39 0.32 3.1e-16 Motion sickness; BRCA cis rs312273 0.530 rs278921 chr12:41377739 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -9.26 -0.34 3.1e-19 Bipolar disorder; BRCA cis rs7524258 0.900 rs2412151 chr1:7303216 G/C cg07173049 chr1:7289937 CAMTA1 0.39 9.5 0.35 4e-20 Tourette's syndrome or obsessive-compulsive disorder; BRCA trans rs79976124 0.877 rs79507557 chr6:66640908 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.76 0.39 6.29e-25 Type 2 diabetes; BRCA cis rs11585357 0.947 rs2977304 chr1:17611615 T/C cg08277548 chr1:17600880 PADI3 0.6 10.95 0.4 1.06e-25 Hair shape; BRCA cis rs965469 0.895 rs6051841 chr20:3392871 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.17 -0.37 1.27e-22 IFN-related cytopenia; BRCA cis rs701145 0.585 rs1713839 chr3:153829105 A/G cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.89e-18 Coronary artery disease; BRCA cis rs1707322 0.826 rs10890349 chr1:46249955 T/C cg06784218 chr1:46089804 CCDC17 0.52 12.36 0.44 1.3e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs367943 0.604 rs28519541 chr5:113006931 C/G cg12552261 chr5:112820674 MCC 0.42 8.37 0.31 3.69e-16 Type 2 diabetes; BRCA cis rs2625529 0.652 rs2278987 chr15:72409769 T/C cg16672083 chr15:72433130 SENP8 0.66 15.88 0.53 4.17e-48 Red blood cell count; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg00166722 chr3:10149974 C3orf24 0.65 13.02 0.46 1.52e-34 Alzheimer's disease; BRCA cis rs10465746 0.545 rs12145516 chr1:84480376 A/G cg10977910 chr1:84465055 TTLL7 0.52 10.69 0.39 1.23e-24 Obesity-related traits; BRCA cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.43 -8.73 -0.33 2.23e-17 Response to bleomycin (chromatid breaks); BRCA cis rs13102973 0.640 rs6857995 chr4:135834193 G/A cg14419869 chr4:135874104 NA 0.48 9.72 0.36 6.15e-21 Subjective well-being; BRCA cis rs2624839 0.704 rs2526384 chr3:50181136 C/T cg24110177 chr3:50126178 RBM5 -0.47 -11.43 -0.41 1.13e-27 Intelligence (multi-trait analysis); BRCA cis rs514406 0.679 rs545719 chr1:53304922 T/C cg16325326 chr1:53192061 ZYG11B 0.58 12.68 0.45 5.16e-33 Monocyte count; BRCA cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg23711669 chr6:146136114 FBXO30 0.79 18.66 0.59 2.27e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA cis rs367943 0.712 rs255861 chr5:112745327 G/A cg12552261 chr5:112820674 MCC 0.36 7.87 0.3 1.51e-14 Type 2 diabetes; BRCA cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg10845886 chr2:3471009 TTC15 -0.53 -11.8 -0.42 3.35e-29 Neurofibrillary tangles; BRCA cis rs17401966 0.931 rs3748579 chr1:10420937 C/T cg19773385 chr1:10388646 KIF1B -0.38 -8.28 -0.31 6.99e-16 Hepatocellular carcinoma; BRCA cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg02544614 chr20:61657117 NA 0.28 7.85 0.3 1.8e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg10802521 chr3:52805072 NEK4 0.34 9.45 0.35 6.05e-20 Bipolar disorder; BRCA cis rs12048904 0.505 rs10493936 chr1:101213335 A/T cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.44 -9.56 -0.35 2.5e-20 Multiple sclerosis; BRCA cis rs13191362 0.507 rs2023038 chr6:163119280 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.52 -10.39 -0.38 1.84e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1691799 0.899 rs1168302 chr12:66737518 C/T cg16791601 chr12:66731901 HELB -0.69 -19.41 -0.61 2.66e-66 White blood cell count (basophil); BRCA cis rs7617773 0.780 rs35190747 chr3:48343290 C/T cg11946769 chr3:48343235 NME6 0.69 13.87 0.48 2.01e-38 Coronary artery disease; BRCA cis rs7246657 0.722 rs2927747 chr19:38159530 C/T cg23950597 chr19:37808831 NA 0.54 9.08 0.34 1.3e-18 Coronary artery calcification; BRCA trans rs7824557 0.767 rs2060463 chr8:11161610 T/G cg15556689 chr8:8085844 FLJ10661 0.38 8.85 0.33 8.82e-18 Retinal vascular caliber; BRCA cis rs3862030 0.720 rs2025713 chr10:104230156 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.12e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs4076764 0.846 rs4255362 chr1:163424630 G/A cg24596788 chr1:163392923 NA -0.32 -8.44 -0.32 2.18e-16 Motion sickness; BRCA trans rs7200543 1.000 rs35574015 chr16:15146061 T/C cg24683922 chr1:11983373 KIAA2013 -0.36 -8.17 -0.31 1.64e-15 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA trans rs2262909 0.962 rs4932952 chr19:22246788 G/A cg17074339 chr11:11642133 GALNTL4 0.42 8.14 0.31 2.13e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs9443645 0.527 rs9361479 chr6:79723755 T/A cg05283184 chr6:79620031 NA -0.36 -8.23 -0.31 1.02e-15 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg00149659 chr3:10157352 C3orf10 0.8 14.13 0.49 1.23e-39 Alzheimer's disease; BRCA cis rs9297145 0.916 rs4236540 chr7:98769025 A/C cg05967295 chr7:98741636 SMURF1 0.88 21.32 0.64 1.41e-76 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs6456156 0.586 rs2345753 chr6:167484344 T/A cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg11366901 chr6:160182831 ACAT2 0.78 15.39 0.52 1.14e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs1997103 0.954 rs56030000 chr7:55405750 A/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA trans rs617791 0.508 rs2276132 chr11:65770545 G/A cg17712092 chr4:129076599 LARP1B -0.48 -10.48 -0.38 8.06e-24 Breast cancer; BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg22920501 chr2:26401640 FAM59B -0.66 -11.54 -0.42 3.93e-28 Gut microbiome composition (summer); BRCA cis rs919433 0.647 rs1979239 chr2:198498316 T/G cg00792783 chr2:198669748 PLCL1 0.41 9.06 0.34 1.56e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10129255 0.518 rs10150460 chr14:107133196 C/G cg07958169 chr14:107095056 NA 0.37 7.87 0.3 1.47e-14 Kawasaki disease; BRCA cis rs9831754 1.000 rs9831754 chr3:78353591 A/C cg06138941 chr3:78371609 NA -0.81 -18.01 -0.58 6.22e-59 Calcium levels; BRCA cis rs35306767 0.953 rs35693858 chr10:979813 C/T cg26597838 chr10:835615 NA 0.88 14.75 0.5 1.43e-42 Eosinophil percentage of granulocytes; BRCA cis rs875971 0.929 rs778692 chr7:65872449 A/G cg18876405 chr7:65276391 NA 0.56 13.33 0.47 6.11e-36 Aortic root size; BRCA cis rs10193935 0.901 rs17029411 chr2:42479149 G/A cg27598129 chr2:42591480 NA -0.65 -10.81 -0.39 4.05e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9311474 0.967 rs610060 chr3:52273421 G/A cg18404041 chr3:52824283 ITIH1 0.29 8.19 0.31 1.44e-15 Electroencephalogram traits; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg16812893 chr21:31813075 KRTAP15-1 0.4 10.14 0.37 1.63e-22 HDL cholesterol; BRCA trans rs2736337 0.530 rs2003422 chr8:11303137 G/C cg06636001 chr8:8085503 FLJ10661 0.45 8.61 0.32 5.57e-17 Rheumatoid arthritis; BRCA cis rs4285028 0.747 rs12496318 chr3:121561500 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.83 15.31 0.52 2.69e-45 Multiple sclerosis; BRCA cis rs6815814 0.950 rs11725779 chr4:38811668 G/A cg06935464 chr4:38784597 TLR10 0.51 8.2 0.31 1.32e-15 Breast cancer; BRCA cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg22974920 chr21:40686053 BRWD1 -0.36 -8.02 -0.3 5.17e-15 Menarche (age at onset); BRCA cis rs10927875 0.541 rs1739841 chr1:16342727 A/G cg22431228 chr1:16359049 CLCNKA -0.44 -9.81 -0.36 2.97e-21 Dilated cardiomyopathy; BRCA trans rs7726839 0.526 rs11960158 chr5:568665 C/T cg25482853 chr8:67687455 SGK3 0.78 13.92 0.48 1.13e-38 Obesity-related traits; BRCA cis rs9443645 0.527 rs36128361 chr6:79684340 C/G cg09184832 chr6:79620586 NA -0.43 -8.41 -0.32 2.66e-16 Intelligence (multi-trait analysis); BRCA cis rs3740540 0.507 rs2362500 chr10:126290431 T/C cg04949429 chr10:126290192 LHPP 0.43 12.23 0.44 4.55e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs2153535 0.580 rs9406170 chr6:8514153 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.53 0.5 1.53e-41 Motion sickness; BRCA cis rs4363385 0.818 rs451939 chr1:153006877 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.04 0.75 7.55e-119 Cognitive function; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -8.13 -0.31 2.18e-15 Longevity;Endometriosis; BRCA cis rs6088580 0.634 rs6059860 chr20:33063830 A/C cg24642439 chr20:33292090 TP53INP2 0.54 11.61 0.42 2e-28 Glomerular filtration rate (creatinine); BRCA trans rs4714291 0.832 rs6936016 chr6:40097013 A/G cg02267698 chr19:7991119 CTXN1 -0.46 -9.48 -0.35 5.06e-20 Strep throat; BRCA cis rs1557765 0.527 rs2018218 chr11:17390855 A/G cg04705435 chr11:17411270 KCNJ11 0.34 7.94 0.3 9.25e-15 Body mass index;Social communication problems; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg18402987 chr7:1209562 NA 0.83 12.02 0.43 3.93e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11577318 0.853 rs3795684 chr1:26632781 C/T cg04990556 chr1:26633338 UBXN11 -0.47 -9.28 -0.34 2.69e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg11752832 chr7:134001865 SLC35B4 -0.42 -9.7 -0.36 7.63e-21 Mean platelet volume; BRCA cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg16179182 chr5:140090404 VTRNA1-1 0.44 10.32 0.38 3.3e-23 Depressive symptoms (multi-trait analysis); BRCA trans rs11165623 0.792 rs6671371 chr1:96977039 A/G cg10631902 chr5:14652156 NA -0.5 -15.43 -0.52 6.5e-46 Hip circumference;Waist circumference; BRCA cis rs1707322 0.721 rs10890333 chr1:46100322 T/C cg06784218 chr1:46089804 CCDC17 0.51 12.51 0.44 2.9e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg01579765 chr21:45077557 HSF2BP -0.4 -9.99 -0.37 6.41e-22 Mean corpuscular volume; BRCA cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs10791323 0.660 rs10791332 chr11:133732150 A/G cg06766960 chr11:133703094 NA -0.52 -11.89 -0.43 1.37e-29 Childhood ear infection; BRCA cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.93 0.4 1.35e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9388451 0.626 rs1343116 chr6:126069702 C/A cg05901451 chr6:126070800 HEY2 -0.56 -14.88 -0.51 3.19e-43 Brugada syndrome; BRCA cis rs11098499 0.754 rs7672372 chr4:120248406 A/G cg09307838 chr4:120376055 NA 0.62 13.22 0.46 1.98e-35 Corneal astigmatism; BRCA cis rs9403521 1.000 rs12528456 chr6:144003706 A/G cg18240653 chr6:144019428 PHACTR2 -0.4 -8.0 -0.3 5.81e-15 Obesity-related traits; BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg26314531 chr2:26401878 FAM59B -0.63 -10.72 -0.39 8.94e-25 Gut microbiome composition (summer); BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.11 0.34 1.01e-18 Platelet count; BRCA cis rs10046574 0.831 rs56285116 chr7:135164950 C/T cg27474649 chr7:135195673 CNOT4 0.61 8.89 0.33 6.04e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg19784903 chr17:45786737 TBKBP1 -0.35 -8.22 -0.31 1.14e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1949733 1.000 rs6447875 chr4:8503206 T/C cg11789530 chr4:8429930 ACOX3 0.69 18.19 0.58 6.7e-60 Response to antineoplastic agents; BRCA cis rs727479 0.502 rs28757200 chr15:51504061 C/T cg19946085 chr15:51559439 CYP19A1 -0.3 -8.49 -0.32 1.45e-16 Estradiol levels; BRCA cis rs11711311 0.826 rs13077644 chr3:113467777 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -10.47 -0.38 8.71e-24 IgG glycosylation; BRCA cis rs35306767 0.669 rs2101051 chr10:1158791 G/T cg20503657 chr10:835505 NA 0.73 10.44 0.38 1.1e-23 Eosinophil percentage of granulocytes; BRCA cis rs3008870 0.755 rs12562761 chr1:67396739 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.09 0.49 1.82e-39 Lymphocyte percentage of white cells; BRCA cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs9640161 0.789 rs28432021 chr7:150046235 G/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.5 -12.5 -0.44 2.99e-32 Blood protein levels;Circulating chemerin levels; BRCA cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg17971929 chr21:40555470 PSMG1 -0.48 -10.57 -0.39 3.68e-24 Menarche (age at onset); BRCA cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg04455712 chr21:45112962 RRP1B 0.41 10.56 0.39 3.72e-24 Mean corpuscular volume; BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg27170947 chr2:26402098 FAM59B -0.93 -16.65 -0.55 5.69e-52 Gut microbiome composition (summer); BRCA cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg21535247 chr6:8435926 SLC35B3 0.39 8.7 0.33 2.7e-17 Motion sickness; BRCA trans rs57221529 0.766 rs4957053 chr5:575927 T/C cg11887960 chr12:57824829 NA 0.55 8.54 0.32 9.6e-17 Lung disease severity in cystic fibrosis; BRCA cis rs9283706 0.764 rs17218390 chr5:66280426 A/G cg11590213 chr5:66331682 MAST4 0.39 8.05 0.3 3.92e-15 Coronary artery disease; BRCA cis rs7666738 0.830 rs28456179 chr4:98991439 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.52e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4566357 0.576 rs6750845 chr2:227911037 T/G cg05526886 chr2:227700861 RHBDD1 -0.39 -8.12 -0.31 2.34e-15 Coronary artery disease; BRCA cis rs7707921 0.767 rs226202 chr5:81571669 C/T cg15871215 chr5:81402204 ATG10 0.36 8.24 0.31 1.01e-15 Breast cancer; BRCA cis rs2742234 0.541 rs2742235 chr10:43616325 A/G cg02780029 chr10:43622663 RET -0.35 -7.82 -0.3 2.25e-14 Hirschsprung disease; BRCA cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.78 11.17 0.4 1.33e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1005277 0.579 rs2504148 chr10:38400788 A/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.81e-26 Extrinsic epigenetic age acceleration; BRCA cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -9.41 -0.35 8.65e-20 Personality dimensions; BRCA cis rs61931739 0.534 rs11053014 chr12:34103519 G/A cg06521331 chr12:34319734 NA -0.62 -11.18 -0.4 1.22e-26 Morning vs. evening chronotype; BRCA cis rs4588572 0.643 rs10063742 chr5:77759362 A/G cg11547950 chr5:77652471 NA -0.48 -8.41 -0.32 2.77e-16 Triglycerides; BRCA cis rs922182 0.617 rs12324438 chr15:64243436 A/C cg24729988 chr15:64271149 DAPK2 -0.49 -10.43 -0.38 1.31e-23 Blood protein levels; BRCA cis rs9790314 1.000 rs4370045 chr3:160943865 A/G cg03342759 chr3:160939853 NMD3 -0.63 -13.29 -0.47 8.77e-36 Morning vs. evening chronotype; BRCA cis rs7666738 0.606 rs4699611 chr4:99097492 T/G cg05340658 chr4:99064831 C4orf37 0.5 10.99 0.4 7.37e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs2991971 0.967 rs2275276 chr1:45973928 C/T cg15605315 chr1:45957053 TESK2 0.49 10.15 0.37 1.5e-22 High light scatter reticulocyte count; BRCA cis rs6545883 0.894 rs2694634 chr2:61551435 T/C cg15711740 chr2:61764176 XPO1 0.51 13.12 0.46 5.33e-35 Tuberculosis; BRCA cis rs1580019 0.562 rs4720064 chr7:32559638 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.2 0.31 1.29e-15 Cognitive ability; BRCA cis rs1904096 0.506 rs3113863 chr4:95147827 G/C cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.04 -0.37 4.03e-22 Type 2 diabetes; BRCA cis rs9399135 0.967 rs13199205 chr6:135286505 T/C cg24558204 chr6:135376177 HBS1L 0.45 12.47 0.44 4.45e-32 Red blood cell count; BRCA trans rs3733585 0.699 rs28610447 chr4:9971517 T/C cg26043149 chr18:55253948 FECH -0.36 -7.98 -0.3 6.76e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7746199 0.611 rs17750747 chr6:27730334 T/C cg01620082 chr3:125678407 NA -0.92 -10.32 -0.38 3.23e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs12887734 0.546 rs12886637 chr14:104222892 A/G cg08213375 chr14:104286397 PPP1R13B -0.5 -11.23 -0.41 8.19e-27 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs7246657 0.943 rs7408563 chr19:37808585 G/C cg18154014 chr19:37997991 ZNF793 0.54 10.46 0.38 9.45e-24 Coronary artery calcification; BRCA cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.91 0.6 1.2e-63 Tonsillectomy; BRCA cis rs4363385 0.747 rs6587716 chr1:152966705 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -9.37 -0.35 1.23e-19 Inflammatory skin disease; BRCA cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.28e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7809950 0.817 rs2237678 chr7:107203265 T/G cg23024343 chr7:107201750 COG5 -0.51 -10.22 -0.37 7.95e-23 Coronary artery disease; BRCA trans rs6479891 1.000 rs2466128 chr10:65208321 T/C cg14819942 chr15:35414228 NA 0.35 8.55 0.32 9.19e-17 Arthritis (juvenile idiopathic); BRCA cis rs6120849 0.901 rs13037296 chr20:33749228 T/A cg24642439 chr20:33292090 TP53INP2 0.48 8.83 0.33 9.82e-18 Protein C levels; BRCA cis rs10751667 0.666 rs6597958 chr11:978087 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs2832077 0.527 rs2738953 chr21:30238363 G/C cg24692254 chr21:30365293 RNF160 0.5 11.27 0.41 5.47e-27 Cognitive test performance; BRCA cis rs4481887 0.927 rs4282853 chr1:248475127 A/G cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs208520 0.690 rs851467 chr6:66802721 A/G cg07460842 chr6:66804631 NA -1.0 -20.02 -0.62 1.44e-69 Exhaled nitric oxide output; BRCA cis rs36051895 0.554 rs7856773 chr9:5204705 T/C cg02405213 chr9:5042618 JAK2 -0.45 -8.45 -0.32 1.94e-16 Pediatric autoimmune diseases; BRCA cis rs2153535 0.580 rs962590 chr6:8450899 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs10791323 0.569 rs2298738 chr11:133715153 G/C cg15485101 chr11:133734466 NA 0.39 9.35 0.35 1.44e-19 Childhood ear infection; BRCA cis rs7617773 0.817 rs34728236 chr3:48259108 A/G cg11946769 chr3:48343235 NME6 0.68 13.84 0.48 2.69e-38 Coronary artery disease; BRCA trans rs7200543 1.000 rs14347 chr16:15133889 T/G cg24683922 chr1:11983373 KIAA2013 -0.39 -8.91 -0.33 5.47e-18 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg13880726 chr7:1868755 MAD1L1 0.52 9.74 0.36 5.5e-21 Bipolar disorder and schizophrenia; BRCA cis rs7523050 0.643 rs35924015 chr1:109404626 T/C cg08274380 chr1:109419600 GPSM2 0.9 13.16 0.46 3.53e-35 Fat distribution (HIV); BRCA cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg11301795 chr4:187892539 NA -0.3 -9.8 -0.36 3.3e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs10494285 chr1:152982285 G/A cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.15e-18 Inflammatory skin disease; BRCA cis rs769267 0.566 rs7249692 chr19:19670688 T/C cg20644253 chr19:19431407 KIAA0892;SF4 -0.43 -8.08 -0.3 3.23e-15 Tonsillectomy; BRCA cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA cis rs965469 1.000 rs6051712 chr20:3265029 T/A cg25506879 chr20:3388711 C20orf194 -0.51 -10.22 -0.37 8.01e-23 IFN-related cytopenia; BRCA cis rs9816226 0.590 rs872602 chr3:185826028 A/G cg00760338 chr3:185826511 ETV5 0.56 12.08 0.43 2.19e-30 Obesity;Body mass index; BRCA cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg23711669 chr6:146136114 FBXO30 -0.71 -17.1 -0.56 2.85e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs765787 0.530 rs12909987 chr15:45512207 C/T cg25801113 chr15:45476975 SHF 0.37 9.84 0.36 2.33e-21 Uric acid levels; BRCA cis rs17095355 0.818 rs72828263 chr10:111785703 G/A cg00817464 chr10:111662876 XPNPEP1 -0.45 -9.71 -0.36 6.71e-21 Biliary atresia; BRCA cis rs2836974 0.897 rs35064900 chr21:40555492 A/G cg11890956 chr21:40555474 PSMG1 1.1 34.02 0.8 1.5e-145 Cognitive function; BRCA cis rs16858210 0.520 rs35586421 chr3:183544607 G/A cg03417191 chr3:183542750 MAP6D1 -0.66 -11.02 -0.4 5.89e-26 Menopause (age at onset); BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg15112475 chr7:1198522 ZFAND2A -0.59 -13.37 -0.47 3.95e-36 Longevity;Endometriosis; BRCA cis rs66887589 0.837 rs6534135 chr4:120406302 A/G cg09307838 chr4:120376055 NA 0.47 9.76 0.36 4.59e-21 Diastolic blood pressure; BRCA cis rs2153535 0.580 rs7761937 chr6:8459434 A/T cg21535247 chr6:8435926 SLC35B3 0.4 8.92 0.33 4.83e-18 Motion sickness; BRCA cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg14926445 chr8:58193284 C8orf71 -0.43 -8.4 -0.32 2.93e-16 Developmental language disorder (linguistic errors); BRCA cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg15605315 chr1:45957053 TESK2 0.5 10.12 0.37 1.99e-22 High light scatter reticulocyte count; BRCA cis rs2011503 1.000 rs77254326 chr19:19626781 T/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.09 -0.34 1.22e-18 Bipolar disorder; BRCA cis rs6815814 0.861 rs10012017 chr4:38784633 G/T cg06935464 chr4:38784597 TLR10 0.48 9.76 0.36 4.69e-21 Breast cancer; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg27588902 chr6:42928151 GNMT -0.31 -10.27 -0.38 5.08e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg03517284 chr6:25882590 NA 0.37 7.83 0.3 2.04e-14 Intelligence (multi-trait analysis); BRCA cis rs586533 0.752 rs635715 chr11:99495141 G/T cg22878054 chr11:99397252 CNTN5 0.32 8.03 0.3 4.67e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg24642439 chr20:33292090 TP53INP2 -0.42 -8.69 -0.33 2.99e-17 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs523522 0.962 rs4767902 chr12:120910004 C/T cg12219531 chr12:120966889 COQ5 0.56 11.7 0.42 8.42e-29 High light scatter reticulocyte count; BRCA cis rs9393692 0.905 rs34916901 chr6:26286149 G/T cg13736514 chr6:26305472 NA -0.34 -11.49 -0.41 6.69e-28 Educational attainment; BRCA cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg17366294 chr4:99064904 C4orf37 0.42 9.83 0.36 2.53e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs372883 0.648 rs368322 chr21:30717151 C/T cg08807101 chr21:30365312 RNF160 -0.39 -8.45 -0.32 1.94e-16 Pancreatic cancer; BRCA cis rs881375 0.678 rs10760128 chr9:123696325 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.44 9.19 0.34 5.32e-19 Rheumatoid arthritis; BRCA cis rs6912958 0.559 rs376633 chr6:88042785 T/C cg12350822 chr6:88032061 C6orf162;GJB7 0.38 10.99 0.4 7.28e-26 Monocyte percentage of white cells; BRCA cis rs4728302 0.869 rs13221033 chr7:133617487 T/A cg07491979 chr7:133331646 EXOC4 0.36 7.84 0.3 1.92e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg09263875 chr16:632152 PIGQ 0.71 20.51 0.63 3.28e-72 Height; BRCA cis rs9682041 0.627 rs3772172 chr3:170077713 C/T cg11886554 chr3:170076028 SKIL -0.5 -10.25 -0.38 6.46e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs7824557 0.872 rs2572417 chr8:11111462 A/T cg21775007 chr8:11205619 TDH -0.55 -12.02 -0.43 3.69e-30 Retinal vascular caliber; BRCA cis rs703842 0.616 rs10877024 chr12:58226709 C/T cg00677455 chr12:58241039 CTDSP2 0.77 17.43 0.57 6.09e-56 Multiple sclerosis; BRCA cis rs2880765 0.835 rs7174323 chr15:86049719 A/C cg10818794 chr15:86012489 AKAP13 -0.31 -8.62 -0.32 5.27e-17 Coronary artery disease; BRCA cis rs1878931 0.597 rs2680221 chr16:3462595 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -9.8 -0.36 3.15e-21 Body mass index (adult); BRCA cis rs2404602 0.532 rs206205 chr15:76736091 T/G cg23625390 chr15:77176239 SCAPER 0.45 11.31 0.41 3.53e-27 Blood metabolite levels; BRCA cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg00701064 chr4:6280414 WFS1 0.65 14.6 0.5 7.35e-42 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9807989 0.507 rs1420096 chr2:103010912 C/T cg03938978 chr2:103052716 IL18RAP 0.29 8.49 0.32 1.5e-16 Asthma; BRCA cis rs9487051 0.768 rs2483913 chr6:109521042 G/A cg01475377 chr6:109611718 NA -0.45 -11.31 -0.41 3.73e-27 Reticulocyte fraction of red cells; BRCA cis rs4728302 0.869 rs889826 chr7:133595871 A/G cg07491979 chr7:133331646 EXOC4 0.36 7.84 0.3 1.88e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.79 -12.65 -0.45 6.65e-33 Platelet count; BRCA cis rs4730250 0.707 rs257377 chr7:106801088 G/T cg02696742 chr7:106810147 HBP1 -0.62 -9.76 -0.36 4.45e-21 Osteoarthritis; BRCA cis rs4911259 0.552 rs13041458 chr20:31467376 G/T cg13636640 chr20:31349939 DNMT3B -0.45 -11.86 -0.42 1.78e-29 Inflammatory bowel disease; BRCA cis rs12478296 1.000 rs56292923 chr2:243039986 C/T cg06360820 chr2:242988706 NA -0.81 -14.34 -0.49 1.25e-40 Obesity-related traits; BRCA cis rs7666738 0.830 rs7664051 chr4:98766970 C/G cg17366294 chr4:99064904 C4orf37 0.41 9.61 0.36 1.57e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg06618935 chr21:46677482 NA -0.38 -8.56 -0.32 8.68e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9487051 0.676 rs9386775 chr6:109561779 T/C cg01475377 chr6:109611718 NA -0.37 -8.87 -0.33 7.04e-18 Reticulocyte fraction of red cells; BRCA cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg06494592 chr3:125709126 NA -0.5 -8.53 -0.32 1.06e-16 Blood pressure (smoking interaction); BRCA cis rs875971 1.000 rs937495 chr7:65779798 A/G cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.23e-15 Aortic root size; BRCA cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg11247378 chr22:39784982 NA -0.63 -15.67 -0.53 4.38e-47 Intelligence (multi-trait analysis); BRCA cis rs832540 0.966 rs252925 chr5:56203773 G/A cg24531977 chr5:56204891 C5orf35 -0.41 -8.21 -0.31 1.21e-15 Coronary artery disease; BRCA cis rs7178424 0.742 rs12916268 chr15:62175642 G/A cg00456672 chr15:62358751 C2CD4A -0.37 -8.86 -0.33 8.1e-18 Height; BRCA cis rs3858526 0.727 rs10769353 chr11:5954809 C/T cg25319279 chr11:5960081 NA 0.41 9.06 0.34 1.6e-18 DNA methylation (variation); BRCA cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs208520 1.000 rs12190773 chr6:66968194 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 14.6 0.5 6.91e-42 Exhaled nitric oxide output; BRCA cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.24 -0.34 3.54e-19 Menopause (age at onset); BRCA cis rs113835537 0.529 rs117112180 chr11:66293273 A/G cg24851651 chr11:66362959 CCS 0.52 8.95 0.33 3.84e-18 Airway imaging phenotypes; BRCA cis rs2243480 1.000 rs6966322 chr7:65646754 A/G cg18252515 chr7:66147081 NA 1.06 15.97 0.53 1.49e-48 Diabetic kidney disease; BRCA cis rs35740288 0.545 rs11637283 chr15:86316103 C/T cg20737812 chr15:86336631 KLHL25 -0.39 -8.41 -0.32 2.76e-16 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs12477438 0.798 rs6712338 chr2:99585457 A/G cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.67e-36 Chronic sinus infection; BRCA cis rs977987 0.872 rs4888422 chr16:75470576 A/G cg03315344 chr16:75512273 CHST6 0.51 11.78 0.42 3.83e-29 Dupuytren's disease; BRCA cis rs7020830 0.898 rs13289199 chr9:37278064 A/T cg14294708 chr9:37120828 ZCCHC7 1.11 35.23 0.81 7.34e-152 Schizophrenia; BRCA cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg16339924 chr4:17578868 LAP3 0.58 14.07 0.49 2.27e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg10057126 chr4:77819792 ANKRD56 0.67 15.45 0.52 5.51e-46 Emphysema distribution in smoking; BRCA cis rs6460942 0.841 rs17444203 chr7:12461864 C/G cg20607287 chr7:12443886 VWDE 0.51 8.16 0.31 1.74e-15 Coronary artery disease; BRCA cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg27129171 chr3:47204927 SETD2 0.63 13.38 0.47 3.48e-36 Birth weight; BRCA cis rs2239547 0.657 rs7638524 chr3:52874861 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 1.94e-19 Schizophrenia; BRCA cis rs7684253 0.565 rs13108570 chr4:57807083 G/C cg11939399 chr4:57773300 REST 0.29 7.97 0.3 7.4e-15 Migraine; BRCA trans rs656319 0.559 rs17689007 chr8:9974824 G/A cg06636001 chr8:8085503 FLJ10661 -0.39 -8.05 -0.3 3.94e-15 Myopia (pathological); BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.77 0.33 1.57e-17 Platelet count; BRCA cis rs11098499 0.599 rs3864142 chr4:120266191 A/T cg09307838 chr4:120376055 NA 0.59 12.91 0.45 4.81e-34 Corneal astigmatism; BRCA cis rs4820539 1.000 rs916583 chr22:23469267 C/T cg14186256 chr22:23484241 RTDR1 0.77 23.57 0.68 7.11e-89 Bone mineral density; BRCA cis rs782590 0.902 rs4672052 chr2:55732018 A/C cg18811423 chr2:55921094 PNPT1 0.66 19.77 0.62 3.04e-68 Metabolic syndrome; BRCA trans rs7980799 0.653 rs10844613 chr12:33605362 A/G cg26384229 chr12:38710491 ALG10B -0.48 -10.26 -0.38 5.98e-23 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2066819 1.000 rs117683816 chr12:56638267 T/C cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs5167 0.525 rs10402642 chr19:45453878 G/A cg20090143 chr19:45452003 APOC2 0.27 7.91 0.3 1.17e-14 Blood protein levels; BRCA cis rs739401 0.572 rs7111857 chr11:3068106 A/G cg05729581 chr11:3078854 CARS 0.35 8.64 0.32 4.46e-17 Longevity; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg00420348 chr11:830190 EFCAB4A -0.5 -10.47 -0.38 8.97e-24 Mean platelet volume; BRCA cis rs7647973 0.626 rs9829155 chr3:49817450 T/C cg07636037 chr3:49044803 WDR6 -0.5 -8.25 -0.31 9.35e-16 Menarche (age at onset); BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg00166722 chr3:10149974 C3orf24 0.67 13.49 0.47 1.13e-36 Alzheimer's disease; BRCA cis rs9527 0.662 rs10786714 chr10:104598606 G/C cg04362960 chr10:104952993 NT5C2 0.46 10.02 0.37 4.66e-22 Arsenic metabolism; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.13e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs62458065 0.513 rs702831 chr7:32579715 C/T cg20159608 chr7:32802032 NA -0.5 -9.64 -0.36 1.25e-20 Metabolite levels (HVA/MHPG ratio); BRCA cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg05340658 chr4:99064831 C4orf37 0.69 17.5 0.57 2.45e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12760731 0.720 rs67857740 chr1:178402250 A/G cg00404053 chr1:178313656 RASAL2 0.6 7.86 0.3 1.67e-14 Obesity-related traits; BRCA cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg05890377 chr2:74357713 NA 0.5 12.26 0.44 3.51e-31 Gestational age at birth (maternal effect); BRCA cis rs875971 0.767 rs1643394 chr7:65836094 A/G cg11764359 chr7:65958608 NA 0.77 17.42 0.57 6.69e-56 Aortic root size; BRCA cis rs2742234 0.910 rs2505513 chr10:43633537 C/G cg02780029 chr10:43622663 RET -0.39 -9.67 -0.36 1.01e-20 Hirschsprung disease; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg14004847 chr7:1930337 MAD1L1 0.41 8.58 0.32 7.02e-17 Bipolar disorder and schizophrenia; BRCA cis rs10751667 0.643 rs7394436 chr11:970373 G/C ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs8114671 0.562 rs8117491 chr20:33510120 T/C cg07148914 chr20:33460835 GGT7 0.47 9.98 0.37 7.06e-22 Height; BRCA cis rs1975991 0.538 rs1062148 chr3:187964915 T/C cg15417654 chr3:187959138 LPP 0.36 9.22 0.34 4.1e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs17666538 0.585 rs336444 chr8:633123 C/G cg23958373 chr8:599963 NA -0.59 -8.7 -0.33 2.91e-17 IgG glycosylation; BRCA cis rs637571 0.546 rs10791827 chr11:65596546 C/A cg04055107 chr11:65626734 MUS81;CFL1 -0.44 -9.11 -0.34 1.08e-18 Eosinophil percentage of white cells; BRCA cis rs208520 0.661 rs207090 chr6:66783963 T/A cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs7589728 1.000 rs7425670 chr2:88522028 C/T cg07952391 chr2:88470173 THNSL2 0.58 8.08 0.3 3.24e-15 Plasma clusterin levels; BRCA cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs9814567 1.000 rs6782563 chr3:134295959 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.58 18.99 0.6 4.37e-64 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.96 0.43 7.08e-30 Personality dimensions; BRCA cis rs17270561 0.609 rs12663099 chr6:25739518 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.81e-18 Iron status biomarkers; BRCA cis rs9880211 1.000 rs9812579 chr3:136151250 A/G cg21827317 chr3:136751795 NA -0.47 -8.28 -0.31 7.19e-16 Body mass index;Height; BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg08888203 chr3:10149979 C3orf24 0.67 13.29 0.47 8.92e-36 Alzheimer's disease; BRCA cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.65 -0.36 1.14e-20 Tonsillectomy; BRCA cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -9.46 -0.35 5.71e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.65 11.34 0.41 2.67e-27 Platelet count; BRCA cis rs40363 0.620 rs1137454 chr16:3533577 C/G cg22508957 chr16:3507546 NAT15 -0.46 -10.71 -0.39 1.01e-24 Tuberculosis; BRCA trans rs6952808 1.000 rs4601204 chr7:1890925 C/T cg04565464 chr8:145669602 NFKBIL2 0.38 8.28 0.31 7.06e-16 Bipolar disorder and schizophrenia; BRCA cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.64 16.52 0.55 2.64e-51 Colorectal cancer; BRCA cis rs7267979 1.000 rs6050599 chr20:25400240 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.67 -0.32 3.66e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs910316 1.000 rs7156105 chr14:75541954 C/A cg08847533 chr14:75593920 NEK9 0.95 25.2 0.71 7.84e-98 Height; BRCA cis rs782590 0.935 rs10460508 chr2:55882565 A/C cg18811423 chr2:55921094 PNPT1 0.74 25.09 0.7 3.05e-97 Metabolic syndrome; BRCA cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg15921436 chr17:44337874 NA 0.57 10.51 0.38 6.09e-24 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs9467773 0.620 rs2451732 chr6:26622904 A/T cg11502198 chr6:26597334 ABT1 -0.55 -11.78 -0.42 3.94e-29 Intelligence (multi-trait analysis); BRCA cis rs738322 0.775 rs13056506 chr22:38580917 G/T cg25457927 chr22:38595422 NA 0.43 16.76 0.55 1.59e-52 Cutaneous nevi; BRCA cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg09184832 chr6:79620586 NA -0.43 -8.36 -0.31 4.04e-16 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg21770322 chr7:97807741 LMTK2 -0.37 -10.13 -0.37 1.83e-22 Prostate cancer (SNP x SNP interaction); BRCA trans rs12517041 1.000 rs10064195 chr5:23278179 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.97 -0.3 7.41e-15 Calcium levels; BRCA cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg22875332 chr1:76189707 ACADM -0.64 -11.37 -0.41 2.11e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3741404 0.609 rs592271 chr11:63872029 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.31 0.49 1.69e-40 Platelet count; BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.91 18.13 0.58 1.36e-59 Alzheimer's disease; BRCA cis rs9291683 0.632 rs13137074 chr4:10042842 C/T cg02734326 chr4:10020555 SLC2A9 0.38 8.22 0.31 1.17e-15 Bone mineral density; BRCA cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.722 rs16958861 chr19:38124179 G/A cg23950597 chr19:37808831 NA -0.48 -8.18 -0.31 1.54e-15 Coronary artery calcification; BRCA cis rs9649213 0.574 rs7790229 chr7:97919338 G/A cg21770322 chr7:97807741 LMTK2 0.42 11.05 0.4 4.43e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs10242455 0.702 rs73397499 chr7:99039627 T/C cg18809830 chr7:99032528 PTCD1 -0.64 -9.09 -0.34 1.18e-18 Blood metabolite levels; BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.57 -10.59 -0.39 2.92e-24 Alzheimer's disease; BRCA cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg06618935 chr21:46677482 NA -0.37 -8.04 -0.3 4.25e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1577917 1.000 rs12207610 chr6:86688016 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.1 -0.43 1.71e-30 Response to antipsychotic treatment; BRCA cis rs12190007 0.508 rs9406321 chr6:169726841 A/T cg16388071 chr6:169726476 NA 0.5 11.4 0.41 1.54e-27 Obesity-related traits; BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.27 -0.31 7.52e-16 Total body bone mineral density; BRCA cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg16414030 chr3:133502952 NA -0.54 -12.47 -0.44 4.25e-32 Iron status biomarkers; BRCA cis rs6028335 0.674 rs68173814 chr20:37621180 A/G cg16355469 chr20:37678765 NA 0.49 8.95 0.33 3.97e-18 Alcohol and nicotine co-dependence; BRCA cis rs72781680 1.000 rs72781658 chr2:24220141 A/G cg20701182 chr2:24300061 SF3B14 0.66 9.47 0.35 5.4e-20 Lymphocyte counts; BRCA trans rs11764590 0.724 rs55789728 chr7:2107649 A/G cg11693508 chr17:37793320 STARD3 0.4 8.26 0.31 8.23e-16 Neuroticism; BRCA cis rs10751667 0.621 rs11246375 chr11:999620 T/C ch.11.42038R chr11:967971 AP2A2 0.47 14.32 0.49 1.62e-40 Alzheimer's disease (late onset); BRCA cis rs6582630 0.502 rs2387603 chr12:38353389 A/C cg13010199 chr12:38710504 ALG10B 0.45 9.38 0.35 1.16e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs17270561 0.609 rs4711100 chr6:25741954 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs4780401 0.609 rs8047190 chr16:11807097 T/C cg01061890 chr16:11836724 TXNDC11 -0.55 -13.07 -0.46 9.28e-35 Rheumatoid arthritis; BRCA cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg18404041 chr3:52824283 ITIH1 -0.41 -12.15 -0.43 1.07e-30 Bipolar disorder; BRCA cis rs8180040 0.620 rs11709660 chr3:47074927 G/A cg27129171 chr3:47204927 SETD2 -0.71 -17.08 -0.56 3.81e-54 Colorectal cancer; BRCA cis rs7666738 0.606 rs3846446 chr4:99099768 C/A cg05340658 chr4:99064831 C4orf37 0.49 10.79 0.39 4.91e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg25790453 chr13:113633590 MCF2L -0.33 -7.99 -0.3 6.22e-15 Systolic blood pressure; BRCA cis rs72634258 0.554 rs34020118 chr1:7895015 C/T cg26816564 chr1:7831052 VAMP3 0.73 13.01 0.46 1.72e-34 Inflammatory bowel disease; BRCA cis rs10751667 0.600 rs11246376 chr11:999622 C/T cg01483505 chr11:975446 AP2A2 0.3 8.09 0.3 2.92e-15 Alzheimer's disease (late onset); BRCA cis rs11229555 0.645 rs12294062 chr11:58175603 G/T cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12762955 0.519 rs7094331 chr10:1022816 T/C cg19847866 chr10:1019161 NA 0.47 10.3 0.38 4.19e-23 Response to angiotensin II receptor blocker therapy; BRCA cis rs4268898 0.560 rs2384007 chr2:24514841 A/G cg06627628 chr2:24431161 ITSN2 -0.76 -14.0 -0.48 4.71e-39 Asthma; BRCA cis rs6089829 0.962 rs4809455 chr20:61660781 G/C cg02544614 chr20:61657117 NA 0.29 8.22 0.31 1.12e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs13256369 0.755 rs12550057 chr8:8562268 G/A cg06671706 chr8:8559999 CLDN23 0.43 8.34 0.31 4.4e-16 Obesity-related traits; BRCA cis rs6088813 0.961 rs6060369 chr20:33907161 A/G cg14752227 chr20:34000481 UQCC 0.4 8.27 0.31 7.54e-16 Height; BRCA cis rs7568458 0.660 rs55692129 chr2:85792404 A/T cg02493740 chr2:85810744 VAMP5 -0.59 -11.93 -0.43 8.76e-30 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs17376456 0.569 rs6895356 chr5:93060781 A/G cg25358565 chr5:93447407 FAM172A 0.65 11.51 0.41 5.53e-28 Diabetic retinopathy; BRCA cis rs13191362 1.000 rs73035025 chr6:163000988 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs28647808 0.881 rs4962139 chr9:136267869 C/T cg01472961 chr9:136215657 SNORD36B;MED22;SNORD24;RPL7A -0.74 -11.39 -0.41 1.69e-27 Blood protein levels; BRCA cis rs7086627 0.515 rs6585994 chr10:82191643 A/G cg00277334 chr10:82204260 NA -0.51 -11.42 -0.41 1.24e-27 Post bronchodilator FEV1; BRCA cis rs8005677 1.000 rs4982709 chr14:23394699 C/T cg01529538 chr14:23388837 RBM23 0.41 10.97 0.4 9.28e-26 Cognitive ability (multi-trait analysis); BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg18538332 chr22:24372958 LOC391322 0.51 12.01 0.43 4e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6543140 0.964 rs1523206 chr2:103070175 A/T cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs6582630 0.502 rs11504451 chr12:38425294 G/A cg13010199 chr12:38710504 ALG10B 0.45 9.29 0.35 2.32e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs8062405 0.723 rs62031562 chr16:28609329 A/T cg16576597 chr16:28551801 NUPR1 0.34 9.04 0.34 1.78e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9297145 0.509 rs13222381 chr7:98785024 T/G cg05967295 chr7:98741636 SMURF1 -0.6 -12.99 -0.46 2.13e-34 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs13046373 0.535 rs2832964 chr21:32014012 A/C cg14062083 chr21:31802829 KRTAP13-4 0.35 9.45 0.35 6.14e-20 HDL cholesterol; BRCA cis rs3806843 1.000 rs10223116 chr5:140192643 C/T cg11822812 chr5:140052017 DND1 0.29 7.83 0.3 2.04e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg11366901 chr6:160182831 ACAT2 0.81 15.75 0.53 1.83e-47 Age-related macular degeneration (geographic atrophy); BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.56 0.39 3.81e-24 Tonsillectomy; BRCA cis rs2243480 1.000 rs1392104 chr7:65759107 G/A cg18252515 chr7:66147081 NA 1.04 15.68 0.53 4.14e-47 Diabetic kidney disease; BRCA trans rs2262909 0.849 rs10420483 chr19:22190378 A/G cg17074339 chr11:11642133 GALNTL4 -0.42 -7.9 -0.3 1.23e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA trans rs11088226 0.681 rs2833897 chr21:33931792 T/C cg09050820 chr6:167586206 TCP10L2 0.77 13.28 0.47 1.06e-35 Gastritis; BRCA cis rs6604026 0.524 rs532834 chr1:93468062 A/T cg17283838 chr1:93427260 FAM69A 0.48 10.43 0.38 1.26e-23 Multiple sclerosis; BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.71e-14 Tonsillectomy; BRCA cis rs7618915 0.508 rs11717043 chr3:52656092 A/T cg10802521 chr3:52805072 NEK4 -0.32 -8.24 -0.31 9.76e-16 Bipolar disorder; BRCA cis rs4423214 0.879 rs1790345 chr11:71145941 G/A cg05163923 chr11:71159392 DHCR7 -0.52 -10.5 -0.38 6.85e-24 Vitamin D levels; BRCA cis rs2599510 0.703 rs58852184 chr2:32729763 A/T cg02381751 chr2:32503542 YIPF4 0.41 8.12 0.31 2.33e-15 Interleukin-18 levels; BRCA cis rs7945718 0.870 rs10765988 chr11:12731218 C/T cg25843174 chr11:12811716 TEAD1 0.24 8.9 0.33 5.66e-18 Educational attainment (years of education); BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.42 -0.32 2.46e-16 Total body bone mineral density; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg13397359 chr6:42928475 GNMT 0.66 16.15 0.54 1.89e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs28595532 1.000 rs11938970 chr4:119660152 A/G cg21605333 chr4:119757512 SEC24D 0.97 10.98 0.4 8.48e-26 Cannabis dependence symptom count; BRCA cis rs35150201 0.529 rs7806221 chr7:135318779 T/C cg23117316 chr7:135346802 PL-5283 -0.3 -8.49 -0.32 1.43e-16 Plateletcrit;Mean corpuscular hemoglobin;Mean platelet volume; BRCA cis rs10411936 0.712 rs3810198 chr19:16601194 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.7 0.36 7.36e-21 White blood cell count;Multiple sclerosis; BRCA cis rs586533 0.881 rs602718 chr11:99499998 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs919433 0.963 rs2043016 chr2:198146381 C/T cg10820045 chr2:198174542 NA -0.41 -9.63 -0.36 1.36e-20 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1506636 1.000 rs2402671 chr7:123355483 T/C cg03229431 chr7:123269106 ASB15 -0.61 -13.96 -0.48 7.91e-39 Plateletcrit;Platelet count; BRCA trans rs12517041 0.935 rs28493622 chr5:23282147 T/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -8.65 -0.32 4.09e-17 Monocyte percentage of white cells; BRCA cis rs9859260 0.614 rs493661 chr3:195786489 T/A cg03462622 chr3:195777018 TFRC -0.38 -8.58 -0.32 7.44e-17 Mean corpuscular volume; BRCA cis rs2191566 1.000 rs369106 chr19:44506930 C/T cg20607764 chr19:44506953 ZNF230 0.49 10.99 0.4 7.48e-26 Acute lymphoblastic leukemia (childhood); BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg16362232 chr11:430036 ANO9 0.5 8.03 0.3 4.82e-15 Body mass index; BRCA cis rs13394619 0.935 rs6746291 chr2:11728381 T/C cg07314298 chr2:11723111 GREB1 -0.54 -12.84 -0.45 9.83e-34 Endometriosis; BRCA cis rs919433 0.680 rs7605813 chr2:198375329 C/G cg00792783 chr2:198669748 PLCL1 0.39 8.73 0.33 2.14e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs7647973 0.588 rs9883000 chr3:49667691 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.97 -0.33 3.38e-18 Menarche (age at onset); BRCA cis rs7903847 0.642 rs7909345 chr10:99150794 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.54 -0.32 1.01e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs12477438 0.520 rs2516830 chr2:99773702 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs3784262 1.000 rs9325 chr15:58245986 A/T cg12031962 chr15:58353849 ALDH1A2 0.48 12.88 0.45 6.53e-34 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11098499 0.954 rs11722872 chr4:120233030 G/C cg09307838 chr4:120376055 NA 0.7 14.62 0.5 5.68e-42 Corneal astigmatism; BRCA cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg03709012 chr19:19516395 GATAD2A -0.79 -17.85 -0.58 3.94e-58 Tonsillectomy; BRCA cis rs10751667 0.666 rs7124480 chr11:971601 G/A cg10932868 chr11:921992 NA 0.51 13.14 0.46 4.43e-35 Alzheimer's disease (late onset); BRCA cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg16482183 chr6:26056742 HIST1H1C 0.74 14.73 0.5 1.78e-42 Iron status biomarkers; BRCA cis rs4363385 0.693 rs310102 chr1:153042423 T/C cg24667326 chr1:152973720 SPRR3 -0.3 -7.95 -0.3 8.53e-15 Inflammatory skin disease; BRCA cis rs2153535 0.580 rs7741403 chr6:8530578 C/T cg21535247 chr6:8435926 SLC35B3 -0.38 -8.61 -0.32 5.8e-17 Motion sickness; BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 18.98 0.6 4.6e-64 Platelet count; BRCA cis rs9291683 0.595 rs11731110 chr4:10037346 T/C cg11266682 chr4:10021025 SLC2A9 0.49 12.82 0.45 1.23e-33 Bone mineral density; BRCA cis rs2806561 0.577 rs488438 chr1:23498999 T/A cg12483005 chr1:23474871 LUZP1 0.49 10.59 0.39 2.89e-24 Height; BRCA cis rs13095912 0.962 rs12374077 chr3:185317674 G/C cg11274856 chr3:185301563 NA 0.34 8.53 0.32 1.09e-16 Systolic blood pressure; BRCA trans rs75804782 0.641 rs72983853 chr2:239324210 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 9.68 0.36 8.84e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs12497850 0.931 rs13316620 chr3:49045355 T/C cg07636037 chr3:49044803 WDR6 0.97 28.18 0.74 3.48e-114 Parkinson's disease; BRCA cis rs2011503 1.000 rs2916072 chr19:19525712 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -9.12 -0.34 9.68e-19 Bipolar disorder; BRCA cis rs6831352 0.851 rs1230164 chr4:99986023 C/G cg13256891 chr4:100009986 ADH5 0.43 8.15 0.31 1.98e-15 Alcohol dependence; BRCA cis rs17818399 0.547 rs4952831 chr2:46761181 G/A cg02822958 chr2:46747628 ATP6V1E2 0.64 11.6 0.42 2.21e-28 Height; BRCA cis rs3768617 0.528 rs6686682 chr1:183080539 A/G ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg18301423 chr5:131593218 PDLIM4 -0.37 -9.54 -0.35 2.91e-20 Acylcarnitine levels; BRCA cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg21132104 chr15:45694354 SPATA5L1 0.75 16.78 0.55 1.22e-52 Homoarginine levels; BRCA cis rs5850 0.557 rs10270788 chr7:23189000 T/C cg23682824 chr7:23144976 KLHL7 0.42 10.97 0.4 9.04e-26 Blood protein levels; BRCA cis rs13256369 0.851 rs13249700 chr8:8563637 C/T cg18904891 chr8:8559673 CLDN23 0.65 12.91 0.45 4.83e-34 Obesity-related traits; BRCA cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg16339924 chr4:17578868 LAP3 0.57 13.8 0.48 4.27e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs61931739 0.500 rs34287388 chr12:34444626 C/A cg06521331 chr12:34319734 NA -0.56 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs911119 1.000 rs3787499 chr20:23616807 G/A cg16589663 chr20:23618590 CST3 0.47 8.72 0.33 2.36e-17 Chronic kidney disease; BRCA cis rs736801 0.836 rs2522052 chr5:131798487 C/T cg07395648 chr5:131743802 NA 0.37 8.71 0.33 2.51e-17 Breast cancer;Mosquito bite size; BRCA cis rs1008375 1.000 rs4698634 chr4:17630192 A/C cg15017067 chr4:17643749 FAM184B -0.28 -8.49 -0.32 1.46e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3740540 0.530 rs2362506 chr10:126290751 C/G cg04949429 chr10:126290192 LHPP 0.44 12.32 0.44 2e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs6570726 0.620 rs367693 chr6:145815949 G/A cg13319975 chr6:146136371 FBXO30 -0.6 -13.43 -0.47 2.05e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467773 0.620 rs2504571 chr6:26643435 C/T cg09904177 chr6:26538194 HMGN4 0.46 14.48 0.5 2.64e-41 Intelligence (multi-trait analysis); BRCA trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21659725 chr3:3221576 CRBN -0.72 -22.05 -0.66 1.44e-80 Intelligence (multi-trait analysis); BRCA cis rs34311866 0.808 rs11728344 chr4:963755 T/C cg07828340 chr4:882639 GAK 0.86 10.53 0.38 5.31e-24 Parkinson's disease; BRCA cis rs6138458 1.000 rs227632 chr20:24913729 G/A cg06937882 chr20:24974362 C20orf3 -0.48 -9.12 -0.34 9.53e-19 Blood protein levels; BRCA cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.88 13.24 0.46 1.53e-35 Lung cancer in ever smokers; BRCA cis rs9527 0.571 rs3740400 chr10:104629465 T/G cg04362960 chr10:104952993 NT5C2 0.42 10.11 0.37 2.12e-22 Arsenic metabolism; BRCA cis rs1997103 1.000 rs6977292 chr7:55396335 T/C cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6964587 1.000 rs417 chr7:91581121 C/A cg17063962 chr7:91808500 NA -0.57 -13.48 -0.47 1.2e-36 Breast cancer; BRCA cis rs2425143 1.000 rs2425141 chr20:34350123 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.14 -0.37 1.61e-22 Blood protein levels; BRCA cis rs7786877 0.723 rs6969584 chr7:100209747 A/C cg16850897 chr7:100343110 ZAN -0.57 -10.58 -0.39 3.17e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.36 0.44 1.23e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs1997103 1.000 rs2177803 chr7:55410773 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3754648 0.525 rs3768924 chr2:237023108 G/C cg13658143 chr2:237026123 AGAP1 0.48 10.75 0.39 6.58e-25 Craniofacial microsomia; BRCA trans rs6582630 0.519 rs12819814 chr12:38332568 G/C cg06521331 chr12:34319734 NA -0.47 -8.66 -0.32 3.72e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg04476341 chr5:669733 TPPP 0.39 7.83 0.3 2.02e-14 Lung disease severity in cystic fibrosis; BRCA cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg12386194 chr3:101231763 SENP7 0.41 8.77 0.33 1.63e-17 Colorectal cancer; BRCA cis rs7267979 1.000 rs6037099 chr20:25356876 T/G cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.580 rs9328483 chr6:8521295 A/G cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.27e-41 Motion sickness; BRCA cis rs3008870 0.583 rs2031495 chr1:67421714 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.88 16.4 0.54 9.96e-51 Lymphocyte percentage of white cells; BRCA cis rs9487051 0.872 rs1111866 chr6:109610846 A/C cg21918786 chr6:109611834 NA 0.48 13.95 0.48 8.42e-39 Reticulocyte fraction of red cells; BRCA cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs9393692 0.905 rs9393694 chr6:26279296 T/C cg13736514 chr6:26305472 NA -0.35 -11.82 -0.42 2.62e-29 Educational attainment; BRCA cis rs11098499 0.739 rs951570 chr4:120150467 T/C cg09307838 chr4:120376055 NA -0.49 -9.18 -0.34 5.85e-19 Corneal astigmatism; BRCA cis rs9487051 1.000 rs1008084 chr6:109626965 G/A cg21918786 chr6:109611834 NA -0.45 -12.1 -0.43 1.77e-30 Reticulocyte fraction of red cells; BRCA cis rs7809950 0.678 rs6949634 chr7:106984684 G/T cg23024343 chr7:107201750 COG5 -0.46 -9.46 -0.35 5.89e-20 Coronary artery disease; BRCA cis rs35306767 0.855 rs61830900 chr10:871481 C/G cg26597838 chr10:835615 NA 1.29 21.78 0.65 4.37e-79 Eosinophil percentage of granulocytes; BRCA cis rs2380220 0.576 rs4368819 chr6:96031109 T/G cg15832292 chr6:96025679 MANEA 0.56 8.44 0.32 2.06e-16 Behavioural disinhibition (generation interaction); BRCA cis rs9815354 0.812 rs73069292 chr3:41973963 T/C cg03022575 chr3:42003672 ULK4 0.69 9.67 0.36 1.01e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2637030 0.559 rs1559266 chr5:52851931 C/T cg06476337 chr5:52856530 NDUFS4 0.36 8.36 0.31 3.91e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg23711669 chr6:146136114 FBXO30 0.69 15.88 0.53 4.3e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.77 0.33 1.58e-17 Tonsillectomy; BRCA cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.89 0.36 1.54e-21 Lung cancer in ever smokers; BRCA cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg04267008 chr7:1944627 MAD1L1 -0.56 -12.38 -0.44 1.07e-31 Bipolar disorder and schizophrenia; BRCA cis rs7851660 0.967 rs1867280 chr9:100616066 G/C cg13688889 chr9:100608707 NA -0.36 -8.72 -0.33 2.42e-17 Strep throat; BRCA cis rs910316 0.967 rs4899551 chr14:75660246 C/G cg23033748 chr14:75592666 NEK9 -0.38 -9.05 -0.34 1.66e-18 Height; BRCA trans rs9291683 0.655 rs55941493 chr4:10100341 G/A cg26043149 chr18:55253948 FECH -0.36 -8.01 -0.3 5.29e-15 Bone mineral density; BRCA cis rs7575217 0.697 rs6727703 chr2:101698533 G/T cg23907051 chr2:101730305 TBC1D8 0.2 7.84 0.3 1.9e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs36051895 0.658 rs62541531 chr9:5011795 C/T cg02405213 chr9:5042618 JAK2 -0.47 -8.77 -0.33 1.65e-17 Pediatric autoimmune diseases; BRCA cis rs9473147 0.516 rs10948363 chr6:47487762 A/G cg12968598 chr6:47444699 CD2AP 0.46 9.86 0.36 1.85e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs6964587 0.869 rs7778667 chr7:91520816 C/G cg17063962 chr7:91808500 NA -0.53 -12.21 -0.43 5.86e-31 Breast cancer; BRCA cis rs6545883 0.929 rs10190332 chr2:61619267 T/G cg15711740 chr2:61764176 XPO1 0.54 13.64 0.47 2.27e-37 Tuberculosis; BRCA cis rs9814567 1.000 rs7619451 chr3:134233238 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.64 -19.85 -0.62 1.18e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7589728 0.563 rs4972044 chr2:88466196 T/C cg07952391 chr2:88470173 THNSL2 0.67 9.18 0.34 5.92e-19 Plasma clusterin levels; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg27170947 chr2:26402098 FAM59B 0.98 17.0 0.56 9.48e-54 Gut microbiome composition (summer); BRCA cis rs7605378 0.528 rs7592587 chr2:200786516 C/G cg17644776 chr2:200775616 C2orf69 0.43 8.61 0.32 5.51e-17 Osteoporosis; BRCA trans rs2204008 0.693 rs12372025 chr12:38202028 G/A cg06521331 chr12:34319734 NA -0.54 -9.62 -0.36 1.44e-20 Bladder cancer; BRCA cis rs7267979 0.966 rs2257233 chr20:25265984 A/C cg08601574 chr20:25228251 PYGB -0.37 -8.75 -0.33 1.94e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs72781680 0.898 rs72790310 chr2:24116716 C/T cg08917208 chr2:24149416 ATAD2B 0.93 13.77 0.48 6.03e-38 Lymphocyte counts; BRCA cis rs68170813 0.559 rs78553765 chr7:106930787 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.65 -0.32 4.16e-17 Coronary artery disease; BRCA cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs2882667 0.537 rs10057545 chr5:138431008 G/A cg04439458 chr5:138467593 SIL1 -0.29 -7.94 -0.3 9.24e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs208520 0.690 rs207740 chr6:66764132 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 21.05 0.64 4.24e-75 Exhaled nitric oxide output; BRCA trans rs1997103 0.863 rs4480062 chr7:55401299 T/C cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7552404 1.000 rs6593585 chr1:76140273 G/A cg22875332 chr1:76189707 ACADM 0.68 14.82 0.51 6.53e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6977660 0.714 rs12700077 chr7:19791607 A/G cg05791153 chr7:19748676 TWISTNB -0.66 -11.68 -0.42 1.06e-28 Thyroid stimulating hormone; BRCA cis rs2032447 0.575 rs198847 chr6:26106619 C/A cg12310025 chr6:25882481 NA 0.42 9.35 0.35 1.44e-19 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg13319975 chr6:146136371 FBXO30 0.36 8.25 0.31 9.35e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2730245 0.645 rs4909282 chr7:158699797 T/C cg14689365 chr7:158441557 NCAPG2 0.41 8.67 0.32 3.58e-17 Height; BRCA cis rs1215050 0.791 rs165241 chr4:98681112 C/T cg05340658 chr4:99064831 C4orf37 0.45 10.17 0.37 1.26e-22 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs4689592 0.503 rs10516184 chr4:7060959 C/T cg07817883 chr1:32538562 TMEM39B -0.48 -8.25 -0.31 9.05e-16 Monocyte percentage of white cells; BRCA cis rs10851411 0.697 rs72711767 chr15:42843970 T/G cg21293051 chr15:42870591 STARD9 0.51 8.77 0.33 1.58e-17 Glucose homeostasis traits; BRCA cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg02733842 chr7:1102375 C7orf50 -0.63 -11.61 -0.42 2e-28 Bronchopulmonary dysplasia; BRCA cis rs6570726 0.935 rs415590 chr6:145851244 T/C cg23711669 chr6:146136114 FBXO30 0.65 15.3 0.52 2.9e-45 Lobe attachment (rater-scored or self-reported); BRCA trans rs17685 0.743 rs10277259 chr7:75802674 A/C cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg24101359 chr6:42928495 GNMT 0.63 15.44 0.52 6.4e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.68e-16 Putamen volume; BRCA cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg23711669 chr6:146136114 FBXO30 0.77 17.59 0.57 8.37e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs651907 0.557 rs62284199 chr3:101478531 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 14.59 0.5 8.25e-42 Colorectal cancer; BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg03354898 chr7:1950403 MAD1L1 -0.39 -8.25 -0.31 8.79e-16 Bipolar disorder and schizophrenia; BRCA cis rs1568889 1.000 rs61889027 chr11:28281908 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 13.11 0.46 6e-35 Bipolar disorder; BRCA cis rs35146811 0.807 rs6953441 chr7:99617067 G/A cg22906224 chr7:99728672 NA 0.46 8.75 0.33 1.9e-17 Coronary artery disease; BRCA cis rs11229555 0.645 rs12291551 chr11:58176915 T/A cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs514406 0.830 rs533935 chr1:53308807 T/C cg08859206 chr1:53392774 SCP2 -0.48 -10.52 -0.38 5.77e-24 Monocyte count; BRCA cis rs7246657 0.639 rs3112434 chr19:38198148 G/T cg18154014 chr19:37997991 ZNF793 -0.49 -9.26 -0.34 3.1400000000000002e-19 Coronary artery calcification; BRCA cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg11279151 chr3:101281821 RG9MTD1 0.6 14.48 0.5 2.78e-41 Colonoscopy-negative controls vs population controls; BRCA trans rs2727020 0.567 rs1164687 chr11:49290669 G/A cg15704280 chr7:45808275 SEPT13 0.75 16.09 0.54 3.61e-49 Coronary artery disease; BRCA cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg24690094 chr11:67383802 NA -0.52 -11.6 -0.42 2.32e-28 Mean corpuscular volume; BRCA cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.67 -0.36 9.78e-21 Alzheimer's disease (late onset); BRCA cis rs78456975 0.941 rs6755875 chr2:1557109 T/C cg12573674 chr2:1569213 NA -0.48 -9.26 -0.34 3.08e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.64 -0.32 4.59e-17 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg24829409 chr8:58192753 C8orf71 -0.49 -9.25 -0.34 3.45e-19 Developmental language disorder (linguistic errors); BRCA trans rs1997103 1.000 rs6945937 chr7:55407140 C/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs3960554 0.932 rs11975745 chr7:75843524 T/C cg19862616 chr7:65841803 NCRNA00174 0.6 11.68 0.42 1.08e-28 Eotaxin levels; BRCA cis rs9549260 0.753 rs61963264 chr13:41154792 G/A cg21288729 chr13:41239152 FOXO1 0.54 8.42 0.32 2.48e-16 Red blood cell count; BRCA cis rs738322 0.772 rs9619724 chr22:38517880 T/G cg20207973 chr22:38506712 BAIAP2L2 0.39 10.03 0.37 4.24e-22 Cutaneous nevi; BRCA trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg15556689 chr8:8085844 FLJ10661 0.36 9.98 0.37 6.81e-22 Neuroticism; BRCA cis rs4919694 1.000 rs3740394 chr10:104634474 A/G cg04362960 chr10:104952993 NT5C2 0.89 14.05 0.49 2.9e-39 Arsenic metabolism; BRCA cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg15017067 chr4:17643749 FAM184B 0.33 9.67 0.36 9.48e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7618501 0.633 rs11130228 chr3:50003246 C/T cg24110177 chr3:50126178 RBM5 -0.39 -10.7 -0.39 1.08e-24 Intelligence (multi-trait analysis); BRCA cis rs6964587 0.626 rs2269810 chr7:91508837 T/C cg17063962 chr7:91808500 NA -0.53 -12.29 -0.44 2.63e-31 Breast cancer; BRCA trans rs11976180 0.953 rs2951355 chr7:143760562 A/C cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs10782582 0.609 rs1630302 chr1:76412090 A/T cg03433033 chr1:76189801 ACADM -0.4 -8.42 -0.32 2.57e-16 Daytime sleep phenotypes; BRCA cis rs61931739 0.500 rs11053208 chr12:34460029 A/G cg06521331 chr12:34319734 NA -0.52 -10.34 -0.38 2.86e-23 Morning vs. evening chronotype; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.84 -0.53 6.33e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8114671 0.562 rs1801310 chr20:33517014 A/G cg24642439 chr20:33292090 TP53INP2 0.41 8.1 0.31 2.71e-15 Height; BRCA cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg22800045 chr5:56110881 MAP3K1 -0.41 -8.19 -0.31 1.46e-15 Initial pursuit acceleration; BRCA trans rs3733585 0.773 rs13107466 chr4:10019390 G/A cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.3e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs208520 1.000 rs208535 chr6:66962286 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -14.55 -0.5 1.17e-41 Exhaled nitric oxide output; BRCA cis rs7607369 0.782 rs639913 chr2:219365971 A/C cg02176678 chr2:219576539 TTLL4 0.45 11.73 0.42 6.24e-29 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs593982 0.925 rs585272 chr11:65505289 A/G cg08755490 chr11:65554678 OVOL1 1.27 29.33 0.76 1.95e-120 Atopic dermatitis; BRCA cis rs875971 1.000 rs778726 chr7:65828731 C/T cg18876405 chr7:65276391 NA 0.55 13.29 0.47 9.4e-36 Aortic root size; BRCA cis rs17641971 0.684 rs1876717 chr8:49994968 T/G cg00325661 chr8:49890786 NA 0.39 10.79 0.39 4.77e-25 Blood metabolite levels; BRCA cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg24675658 chr1:53192096 ZYG11B 0.8 18.26 0.59 2.98e-60 Monocyte count; BRCA trans rs2204008 0.837 rs2127955 chr12:37969194 A/G cg06521331 chr12:34319734 NA -0.43 -8.52 -0.32 1.16e-16 Bladder cancer; BRCA cis rs6977660 0.714 rs13230381 chr7:19833896 T/C cg07541023 chr7:19748670 TWISTNB 0.54 9.25 0.34 3.21e-19 Thyroid stimulating hormone; BRCA cis rs838147 0.760 rs281408 chr19:49233406 A/C cg13540341 chr19:49222985 MAMSTR -0.35 -9.6 -0.35 1.83e-20 Dietary macronutrient intake; BRCA cis rs7552404 0.690 rs2029681 chr1:76333846 G/A cg03433033 chr1:76189801 ACADM -0.6 -12.27 -0.44 3.15e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9811920 0.742 rs2316263 chr3:99900096 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.41 9.42 0.35 7.8e-20 Axial length; BRCA cis rs36051895 0.659 rs10974935 chr9:5050307 C/T cg02405213 chr9:5042618 JAK2 -0.51 -9.83 -0.36 2.54e-21 Pediatric autoimmune diseases; BRCA cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg08917208 chr2:24149416 ATAD2B 0.94 13.91 0.48 1.3e-38 Lymphocyte counts; BRCA cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg16405210 chr4:1374714 KIAA1530 -0.47 -9.86 -0.36 1.9e-21 Obesity-related traits; BRCA cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg25358565 chr5:93447407 FAM172A 1.15 17.91 0.58 2.07e-58 Diabetic retinopathy; BRCA cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg18225595 chr11:63971243 STIP1 0.53 9.59 0.35 1.91e-20 Mean platelet volume; BRCA cis rs9942416 0.601 rs114547168 chr5:74991903 A/G cg19683494 chr5:74908142 NA 0.44 8.68 0.32 3.17e-17 Age-related disease endophenotypes; BRCA cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg06766960 chr11:133703094 NA -0.62 -12.79 -0.45 1.71e-33 Childhood ear infection; BRCA cis rs9291683 0.610 rs993172 chr4:10324361 G/T cg11266682 chr4:10021025 SLC2A9 0.33 8.54 0.32 9.97e-17 Bone mineral density; BRCA cis rs6942756 1.000 rs11979476 chr7:128993756 G/T cg02491457 chr7:128862824 NA 0.69 13.6 0.47 3.68e-37 White matter hyperintensity burden; BRCA cis rs9300255 0.664 rs7306755 chr12:123767929 G/A cg00376283 chr12:123451042 ABCB9 -0.55 -10.67 -0.39 1.44e-24 Neutrophil percentage of white cells; BRCA cis rs2153535 0.580 rs1414345 chr6:8471537 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs713587 0.563 rs1529897 chr2:25086827 T/G cg04586622 chr2:25135609 ADCY3 0.43 11.09 0.4 3.06e-26 Body mass index in non-asthmatics; BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -12.77 -0.45 2.05e-33 Bipolar disorder and schizophrenia; BRCA cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg11663144 chr21:46675770 NA -0.59 -13.78 -0.48 5.08e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4664304 0.620 rs1039932 chr2:160712772 G/A cg14819504 chr2:160761413 LY75 0.34 8.27 0.31 7.8e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg11301795 chr4:187892539 NA -0.28 -9.24 -0.34 3.54e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs62103177 0.810 rs62103188 chr18:77627661 G/A cg05926928 chr17:57297772 GDPD1 1.2 16.07 0.54 4.68e-49 Opioid sensitivity; BRCA cis rs6542838 0.641 rs6542841 chr2:99489039 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -8.9 -0.33 5.91e-18 Fear of minor pain; BRCA cis rs4363385 0.818 rs2787629 chr1:153011966 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.61 -0.32 5.49e-17 Inflammatory skin disease; BRCA trans rs208515 0.525 rs12204706 chr6:66669930 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.83 -15.54 -0.52 2.08e-46 Exhaled nitric oxide levels; BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs6709815 0.841 rs6740004 chr2:219663153 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -10.43 -0.38 1.28e-23 Reticulocyte count;High light scatter reticulocyte count; BRCA cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg17509989 chr5:176798049 RGS14 0.77 11.93 0.43 9.57e-30 Urate levels in lean individuals; BRCA cis rs1005277 0.579 rs2474568 chr10:38383147 A/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.2 -0.4 1.08e-26 Extrinsic epigenetic age acceleration; BRCA cis rs6087990 0.806 rs992472 chr20:31385269 G/T cg13636640 chr20:31349939 DNMT3B 0.67 20.82 0.64 7.36e-74 Ulcerative colitis; BRCA cis rs7249142 0.562 rs11085253 chr19:19277517 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.48 -11.17 -0.4 1.34e-26 IgG glycosylation; BRCA cis rs4363385 0.818 rs11205167 chr1:152989727 T/G cg25856811 chr1:152973957 SPRR3 -0.31 -8.03 -0.3 4.6e-15 Inflammatory skin disease; BRCA cis rs2882667 0.690 rs825759 chr5:138125939 G/A cg04439458 chr5:138467593 SIL1 0.35 8.59 0.32 6.56e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs919433 0.963 rs12693815 chr2:198168403 T/C cg10820045 chr2:198174542 NA -0.38 -7.87 -0.3 1.57e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7524258 0.900 rs7551574 chr1:7314363 G/T cg07173049 chr1:7289937 CAMTA1 0.4 9.97 0.37 7.52e-22 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.03 20.72 0.63 2.4e-73 Gut microbiome composition (summer); BRCA cis rs7789940 1.000 rs11765693 chr7:75985373 A/G cg10167463 chr7:75959203 YWHAG -0.44 -8.8 -0.33 1.31e-17 Multiple sclerosis; BRCA cis rs79976124 0.719 rs34488909 chr6:66637850 T/C cg07460842 chr6:66804631 NA 0.59 10.46 0.38 9.37e-24 Type 2 diabetes; BRCA cis rs35306767 0.761 rs11253557 chr10:1043667 C/T cg18964960 chr10:1102726 WDR37 0.63 8.49 0.32 1.48e-16 Eosinophil percentage of granulocytes; BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs7147624 1.000 rs2411821 chr14:65896914 G/T cg03016385 chr14:66212404 NA -0.57 -8.9 -0.33 5.83e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1163251 0.837 rs658442 chr1:120244858 T/G cg19096424 chr1:120255104 PHGDH 0.45 10.44 0.38 1.2e-23 Blood metabolite levels; BRCA cis rs4363385 0.782 rs4845515 chr1:153003871 G/T cg24667326 chr1:152973720 SPRR3 -0.32 -8.94 -0.33 4.23e-18 Inflammatory skin disease; BRCA cis rs10911232 0.520 rs10797831 chr1:183036816 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.93 0.56 2.24e-53 Hypertriglyceridemia; BRCA cis rs13108904 0.905 rs1732108 chr4:1276550 C/T cg05665937 chr4:1216051 CTBP1 -0.38 -7.97 -0.3 7.35e-15 Obesity-related traits; BRCA cis rs2180341 0.960 rs9398839 chr6:127665863 G/A cg24812749 chr6:127587940 RNF146 0.87 19.94 0.62 3.91e-69 Breast cancer; BRCA cis rs7582720 1.000 rs72936348 chr2:204064839 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.22 0.44 5.16e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs2762353 0.776 rs942379 chr6:25849620 A/G cg03517284 chr6:25882590 NA -0.52 -11.82 -0.42 2.78e-29 Blood metabolite levels; BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg02951883 chr7:2050386 MAD1L1 0.51 13.02 0.46 1.48e-34 Bipolar disorder and schizophrenia; BRCA cis rs6964587 1.000 rs10225892 chr7:91671020 A/G cg17063962 chr7:91808500 NA 0.58 13.65 0.48 2.13e-37 Breast cancer; BRCA cis rs6570726 0.935 rs585292 chr6:145862228 T/C cg23711669 chr6:146136114 FBXO30 0.63 14.65 0.5 4.22e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 1.000 rs11211243 chr1:46455433 G/C cg06784218 chr1:46089804 CCDC17 0.45 10.85 0.39 2.66e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2380220 0.576 rs7751219 chr6:96018915 G/A cg04719120 chr6:96025338 MANEA 0.52 7.92 0.3 1.02e-14 Behavioural disinhibition (generation interaction); BRCA cis rs7707921 0.881 rs6875409 chr5:81297077 A/G cg15871215 chr5:81402204 ATG10 -0.4 -8.3 -0.31 6.37e-16 Breast cancer; BRCA cis rs2204008 0.604 rs11172718 chr12:38069819 T/C cg13010199 chr12:38710504 ALG10B 0.4 8.24 0.31 9.71e-16 Bladder cancer; BRCA cis rs2505998 0.833 rs1800858 chr10:43595968 A/G cg15436174 chr10:43711423 RASGEF1A -0.43 -8.47 -0.32 1.72e-16 Hirschsprung disease; BRCA cis rs9296092 0.538 rs9469487 chr6:33516943 G/T cg13560919 chr6:33536144 NA -0.85 -18.39 -0.59 6.35e-61 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs875971 0.830 rs6976714 chr7:65891461 G/A cg18876405 chr7:65276391 NA 0.52 11.69 0.42 9.19e-29 Aortic root size; BRCA cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg24642439 chr20:33292090 TP53INP2 0.41 8.06 0.3 3.73e-15 Height; BRCA cis rs2806561 0.704 rs674386 chr1:23521835 G/A cg19743168 chr1:23544995 NA 0.35 8.14 0.31 2.11e-15 Height; BRCA cis rs7613875 0.600 rs2624826 chr3:50155468 T/G cg14019146 chr3:50243930 SLC38A3 0.45 10.75 0.39 6.71e-25 Body mass index; BRCA cis rs2599510 0.783 rs2568464 chr2:32848658 C/T cg02381751 chr2:32503542 YIPF4 -0.42 -8.29 -0.31 6.66e-16 Interleukin-18 levels; BRCA cis rs7914558 1.000 rs7896547 chr10:104866958 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.82 0.39 3.69e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs12971120 0.891 rs2303463 chr18:72168608 G/A cg25817165 chr18:72167213 CNDP2 -0.75 -14.47 -0.5 2.95e-41 Refractive error; BRCA cis rs7927771 0.864 rs60075622 chr11:47449101 T/G cg20307385 chr11:47447363 PSMC3 -0.43 -9.16 -0.34 7.25e-19 Subjective well-being; BRCA cis rs6840258 1.000 rs6819155 chr4:87976178 G/A cg08197287 chr4:87952173 AFF1 -0.43 -8.61 -0.32 5.69e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg11693508 chr17:37793320 STARD3 0.65 12.05 0.43 2.94e-30 Bipolar disorder; BRCA cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg11644478 chr21:40555479 PSMG1 -0.65 -13.77 -0.48 5.47e-38 Cognitive function; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2303759 0.918 rs4802597 chr19:49872085 C/T cg22307029 chr19:49891270 CCDC155 0.5 9.33 0.35 1.68e-19 Multiple sclerosis; BRCA cis rs9788721 0.836 rs72738736 chr15:78765122 G/T cg18825076 chr15:78729989 IREB2 -0.4 -8.39 -0.32 3.12e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA trans rs6951245 0.554 rs11761322 chr7:1151657 A/G cg13565492 chr6:43139072 SRF -0.86 -15.87 -0.53 4.89e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 1.000 rs12506395 chr4:120185094 C/T cg25214090 chr10:38739885 LOC399744 0.48 10.63 0.39 2.15e-24 Corneal astigmatism; BRCA cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg22431228 chr1:16359049 CLCNKA -0.44 -9.14 -0.34 8.46e-19 Dilated cardiomyopathy; BRCA cis rs4363385 0.740 rs1697428 chr1:153015761 C/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.4 -0.32 2.96e-16 Inflammatory skin disease; BRCA cis rs68170813 0.559 rs3823959 chr7:107009379 T/G cg02696742 chr7:106810147 HBP1 -0.54 -8.68 -0.32 3.23e-17 Coronary artery disease; BRCA cis rs6840360 0.554 rs10222838 chr4:152690099 T/C cg22705602 chr4:152727874 NA -0.38 -10.48 -0.38 7.89e-24 Intelligence (multi-trait analysis); BRCA cis rs600806 0.850 rs4970751 chr1:109896600 A/C cg20591472 chr1:110008990 SYPL2 0.33 8.2 0.31 1.35e-15 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.943 rs111757992 chr7:100016354 A/C cg11814155 chr7:99998594 ZCWPW1 0.43 8.07 0.3 3.42e-15 Platelet count; BRCA cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg01877450 chr7:97915802 BRI3 -0.37 -8.49 -0.32 1.41e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg08999081 chr20:33150536 PIGU 0.45 12.54 0.44 2.02e-32 Glomerular filtration rate (creatinine); BRCA cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs7666738 0.830 rs62321564 chr4:98976496 C/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs12579753 0.879 rs10778828 chr12:82117216 C/A cg07923666 chr12:49932857 KCNH3 -0.4 -7.85 -0.3 1.82e-14 Resting heart rate; BRCA cis rs1707322 0.893 rs9919275 chr1:46441360 A/C cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs78487399 0.710 rs6759383 chr2:43805228 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.95 -0.3 8.45e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs13136331 0.680 rs2627680 chr4:88667937 C/T cg22416721 chr4:88570574 DMP1 0.5 12.06 0.43 2.55e-30 Sitting height ratio; BRCA cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg02153584 chr22:29168773 CCDC117 -0.52 -11.22 -0.41 9.03e-27 Lymphocyte counts; BRCA cis rs4845875 0.600 rs6699881 chr1:11836628 T/C cg24844545 chr1:11908347 NPPA 0.37 8.5 0.32 1.29e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs4363385 0.714 rs4845329 chr1:152974454 G/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.83 -0.36 2.5e-21 Inflammatory skin disease; BRCA cis rs636291 0.510 rs1307487 chr1:10506667 G/A cg07384165 chr1:10488281 NA -0.43 -9.35 -0.35 1.49e-19 Prostate cancer; BRCA cis rs1801251 1.000 rs9653383 chr2:233670380 A/C cg08000102 chr2:233561755 GIGYF2 -0.65 -14.0 -0.48 5.1e-39 Coronary artery disease; BRCA cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg22800045 chr5:56110881 MAP3K1 0.65 12.3 0.44 2.42e-31 Initial pursuit acceleration; BRCA trans rs208520 0.690 rs176289 chr6:66766522 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.0 -0.64 7.17e-75 Exhaled nitric oxide output; BRCA cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg23029597 chr12:123009494 RSRC2 -0.62 -12.43 -0.44 6.52e-32 Body mass index; BRCA cis rs6430585 0.528 rs115553816 chr2:136692893 G/A cg07169764 chr2:136633963 MCM6 1.22 23.88 0.69 1.36e-90 Corneal structure; BRCA cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg23719950 chr11:63933701 MACROD1 -0.59 -9.85 -0.36 2.09e-21 Mean platelet volume; BRCA cis rs11792861 0.926 rs7470160 chr9:111844246 C/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.17 0.31 1.69e-15 Menarche (age at onset); BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg25036284 chr2:26402008 FAM59B 0.89 15.63 0.53 7.3e-47 Gut microbiome composition (summer); BRCA cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg11764359 chr7:65958608 NA -0.67 -14.99 -0.51 9.55e-44 Aortic root size; BRCA cis rs6570726 0.935 rs380883 chr6:145822992 A/G cg23711669 chr6:146136114 FBXO30 0.62 14.39 0.49 7.15e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 1.000 rs17733640 chr3:38446742 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.74 20.27 0.63 6.75e-71 Electrocardiographic conduction measures; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.92 0.33 4.74e-18 Tonsillectomy; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg02951883 chr7:2050386 MAD1L1 -0.5 -10.87 -0.4 2.29e-25 Bipolar disorder and schizophrenia; BRCA cis rs113835537 0.529 rs11227502 chr11:66274148 T/G cg24851651 chr11:66362959 CCS 0.44 8.4 0.32 3e-16 Airway imaging phenotypes; BRCA cis rs1552244 0.882 rs56332224 chr3:10037321 G/A cg16606324 chr3:10149918 C3orf24 0.5 9.65 0.36 1.14e-20 Alzheimer's disease; BRCA cis rs7914558 1.000 rs7081075 chr10:104929191 C/T cg04362960 chr10:104952993 NT5C2 0.43 10.38 0.38 1.93e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg14004847 chr7:1930337 MAD1L1 -0.42 -8.37 -0.31 3.52e-16 Schizophrenia; BRCA cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg16414030 chr3:133502952 NA 0.53 12.12 0.43 1.37e-30 Iron status biomarkers; BRCA cis rs1865760 0.928 rs9295673 chr6:25912094 T/G cg17691542 chr6:26056736 HIST1H1C 0.5 10.21 0.37 9.12e-23 Height; BRCA cis rs763121 0.853 rs5750664 chr22:39072769 C/T cg14440974 chr22:39074834 NA -0.38 -9.13 -0.34 8.96e-19 Menopause (age at onset); BRCA cis rs117623576 0.941 rs211424 chr10:32398895 A/G cg03047570 chr10:32398778 NA 0.55 8.49 0.32 1.42e-16 Anti-saccade response; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg12419862 chr22:24373484 LOC391322 -0.64 -14.11 -0.49 1.53e-39 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9443645 0.901 rs10943605 chr6:79655477 G/A cg09184832 chr6:79620586 NA -0.52 -11.37 -0.41 2.02e-27 Intelligence (multi-trait analysis); BRCA cis rs12579753 0.879 rs7958566 chr12:82131478 A/T cg07988820 chr12:82153109 PPFIA2 -0.67 -11.37 -0.41 2.14e-27 Resting heart rate; BRCA cis rs4285028 0.747 rs11928871 chr3:121483388 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -16.27 -0.54 4.89e-50 Multiple sclerosis; BRCA cis rs7666738 0.830 rs1025204 chr4:99023441 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.69e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7072216 0.691 rs7910973 chr10:100166732 G/A cg26618903 chr10:100175079 PYROXD2 -0.31 -9.04 -0.34 1.87e-18 Metabolite levels; BRCA cis rs4891159 0.756 rs55763305 chr18:74161249 G/C cg24786174 chr18:74118243 ZNF516 -0.7 -16.26 -0.54 5.2e-50 Longevity; BRCA cis rs4332037 0.901 rs7791299 chr7:1935598 T/C cg23422044 chr7:1970798 MAD1L1 -0.64 -13.92 -0.48 1.19e-38 Bipolar disorder; BRCA cis rs11098499 0.863 rs3775849 chr4:120450908 G/C cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs6820391 0.816 rs1369355 chr4:54446860 G/A cg04173182 chr4:54446035 LNX1 0.52 11.65 0.42 1.38e-28 Cervical artery dissection; BRCA cis rs7772486 0.641 rs2748489 chr6:146331287 T/G cg23711669 chr6:146136114 FBXO30 0.66 13.23 0.46 1.73e-35 Lobe attachment (rater-scored or self-reported); BRCA trans rs8073060 0.586 rs2523116 chr17:34025460 T/C cg19694781 chr19:47549865 TMEM160 -1.05 -20.92 -0.64 2.11e-74 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7246967 0.673 rs12985825 chr19:22953451 A/C cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs965469 0.779 rs6037548 chr20:3299299 G/A cg25506879 chr20:3388711 C20orf194 -0.43 -8.73 -0.33 2.23e-17 IFN-related cytopenia; BRCA cis rs9287719 0.649 rs7589694 chr2:10700874 T/C cg00105475 chr2:10696890 NA 0.41 9.15 0.34 7.71e-19 Prostate cancer; BRCA cis rs35306767 0.953 rs11253509 chr10:964306 C/T cg26597838 chr10:835615 NA 0.85 15.42 0.52 7.67e-46 Eosinophil percentage of granulocytes; BRCA cis rs1595825 0.891 rs16866940 chr2:198509058 C/T cg19156104 chr2:198669113 PLCL1 -0.43 -8.19 -0.31 1.41e-15 Ulcerative colitis; BRCA cis rs3740540 0.507 rs10794161 chr10:126291327 C/A cg04949429 chr10:126290192 LHPP 0.43 12.1 0.43 1.69e-30 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs2115630 0.967 rs28595395 chr15:85334952 T/C cg11189052 chr15:85197271 WDR73 -0.33 -7.85 -0.3 1.8e-14 P wave terminal force; BRCA cis rs9393777 0.513 rs9368448 chr6:26649355 T/C cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.9699999999999997e-23 Intelligence (multi-trait analysis); BRCA cis rs11602339 1 rs11602339 chr11:47761471 C/T cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Body mass index; BRCA cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs4319547 0.695 rs12314643 chr12:122917423 C/T cg05707623 chr12:122985044 ZCCHC8 -0.39 -8.26 -0.31 8.62e-16 Body mass index; BRCA cis rs2197308 0.655 rs1971964 chr12:37870474 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.0 0.56 9.54e-54 Morning vs. evening chronotype; BRCA cis rs6543140 0.964 rs62154972 chr2:103048738 G/A cg04239558 chr2:103089729 SLC9A4 0.34 9.39 0.35 1.04e-19 Blood protein levels; BRCA cis rs7586879 0.575 rs6712981 chr2:25126230 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.59 0.42 2.64e-28 Body mass index; BRCA trans rs6089829 0.962 rs6062776 chr20:61663736 A/G cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs6479891 1.000 rs4746195 chr10:65307653 A/G cg14819942 chr15:35414228 NA 0.34 8.25 0.31 9.01e-16 Arthritis (juvenile idiopathic); BRCA cis rs9462027 0.651 rs9469870 chr6:34744349 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.27 -8.23 -0.31 1.08e-15 Systemic lupus erythematosus; BRCA cis rs9359856 0.529 rs72915915 chr6:90430593 T/C cg13799429 chr6:90582589 CASP8AP2 -0.66 -8.24 -0.31 9.81e-16 Bipolar disorder; BRCA cis rs1707322 0.963 rs10789478 chr1:46350506 C/T cg03146154 chr1:46216737 IPP 0.49 10.87 0.4 2.28e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9308731 0.644 rs3789064 chr2:111915322 T/C cg04780086 chr2:111875790 ACOXL 0.28 7.91 0.3 1.11e-14 Chronic lymphocytic leukemia; BRCA cis rs3806843 0.933 rs2337987 chr5:140188383 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12292205 chr6:26970375 C6orf41 -0.49 -8.27 -0.31 7.96e-16 Intelligence (multi-trait analysis); BRCA cis rs2832191 0.671 rs73346699 chr21:30515529 C/T cg08807101 chr21:30365312 RNF160 -0.44 -9.38 -0.35 1.17e-19 Dental caries; BRCA cis rs6570726 0.791 rs405206 chr6:145836873 C/A cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.52 -0.35 3.47e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs6580649 1.000 rs9805048 chr12:48403692 C/T cg05342945 chr12:48394962 COL2A1 -0.42 -8.68 -0.32 3.39e-17 Lung cancer; BRCA trans rs6582630 0.502 rs1607867 chr12:38385463 C/T cg06521331 chr12:34319734 NA -0.45 -8.33 -0.31 4.76e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs6570726 0.791 rs6900040 chr6:145893134 C/T cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg02659138 chr7:134003124 SLC35B4 0.36 9.99 0.37 6.2e-22 Mean platelet volume; BRCA trans rs7746199 0.673 rs72847313 chr6:27730082 C/T cg01620082 chr3:125678407 NA -0.92 -10.32 -0.38 3.23e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs1223245 0.740 rs360063 chr1:226036309 A/G cg27179622 chr1:226127290 LEFTY2 -0.32 -9.09 -0.34 1.2e-18 Preschool internalizing problems; BRCA cis rs7833986 0.501 rs72653953 chr8:56970795 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.18 0.46 2.8e-35 Height; BRCA trans rs2797160 1.000 rs2747722 chr6:126009629 A/G cg05039488 chr6:79577232 IRAK1BP1 0.36 8.07 0.3 3.49e-15 Endometrial cancer; BRCA cis rs17401966 1.000 rs11578788 chr1:10422958 A/G cg15208524 chr1:10270712 KIF1B 0.38 7.9 0.3 1.23e-14 Hepatocellular carcinoma; BRCA cis rs6088580 0.634 rs4911151 chr20:32932273 T/C cg08999081 chr20:33150536 PIGU -0.45 -12.33 -0.44 1.73e-31 Glomerular filtration rate (creatinine); BRCA cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg21573476 chr21:45109991 RRP1B 0.34 8.69 0.33 3.01e-17 Mean corpuscular volume; BRCA cis rs7246657 0.551 rs4806413 chr19:37617716 A/T cg18154014 chr19:37997991 ZNF793 0.5 8.11 0.31 2.68e-15 Coronary artery calcification; BRCA cis rs4588572 0.644 rs9293751 chr5:77778296 A/G cg11547950 chr5:77652471 NA -0.42 -8.39 -0.32 3.08e-16 Triglycerides; BRCA cis rs9467773 0.620 rs2451738 chr6:26618459 A/T cg09904177 chr6:26538194 HMGN4 -0.45 -14.14 -0.49 1.13e-39 Intelligence (multi-trait analysis); BRCA cis rs2302729 0.578 rs10774052 chr12:2772171 C/T cg19945202 chr12:2788847 CACNA1C -0.44 -9.83 -0.36 2.39e-21 Sleep quality; BRCA cis rs10193935 0.901 rs1496329 chr2:42688797 T/C cg27598129 chr2:42591480 NA 0.8 12.94 0.46 3.58e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.49 -0.44 3.34e-32 Lymphocyte counts; BRCA cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg01877450 chr7:97915802 BRI3 -0.39 -8.98 -0.33 3.1e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.520 rs6741773 chr2:99738962 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.47 0.66 7.52e-83 Chronic sinus infection; BRCA cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12516959 chr21:47718080 NA -0.42 -9.59 -0.35 1.96e-20 Testicular germ cell tumor; BRCA cis rs1538970 0.816 rs61788356 chr1:46006675 C/T cg05343316 chr1:45956843 TESK2 0.7 14.2 0.49 5.92e-40 Platelet count; BRCA cis rs2191566 0.506 rs396116 chr19:44494583 A/G cg20607764 chr19:44506953 ZNF230 0.36 7.88 0.3 1.46e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs2204008 0.807 rs4123933 chr12:37973539 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.13 0.37 1.89e-22 Bladder cancer; BRCA cis rs7584330 0.784 rs6724766 chr2:238413600 A/G cg14458575 chr2:238380390 NA 0.48 10.47 0.38 8.87e-24 Prostate cancer; BRCA cis rs17685 0.712 rs4552844 chr7:75718095 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.86 -0.33 8.2e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg25036284 chr2:26402008 FAM59B 0.66 10.8 0.39 4.38e-25 Gut microbiome composition (summer); BRCA cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg05347473 chr6:146136440 FBXO30 0.42 8.33 0.31 4.77e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.41 8.56 0.32 8.4e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs509477 1.000 rs531558 chr18:32575286 A/T cg23791764 chr18:32556832 MAPRE2 -0.35 -8.37 -0.31 3.69e-16 Cerebrospinal fluid AB1-42 levels; BRCA cis rs7618915 0.571 rs1961958 chr3:52585990 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.43 8.93 0.33 4.67e-18 Bipolar disorder; BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg25036284 chr2:26402008 FAM59B 0.77 10.7 0.39 1.08e-24 Gut microbiome composition (summer); BRCA trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg03929089 chr4:120376271 NA -0.79 -18.87 -0.6 1.83e-63 Coronary artery disease; BRCA cis rs12474201 0.928 rs35825831 chr2:46932544 T/G cg06386533 chr2:46925753 SOCS5 0.87 18.88 0.6 1.58e-63 Height; BRCA cis rs6088590 0.687 rs13044899 chr20:33287078 G/A cg06115741 chr20:33292138 TP53INP2 0.45 9.94 0.37 9.8e-22 Coronary artery disease; BRCA cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg27535305 chr1:53392650 SCP2 0.32 7.93 0.3 9.73e-15 Monocyte count; BRCA cis rs7617773 0.780 rs6793223 chr3:48364101 C/T cg11946769 chr3:48343235 NME6 0.67 13.64 0.47 2.37e-37 Coronary artery disease; BRCA cis rs8072100 0.967 rs2317826 chr17:45730899 C/T cg08085267 chr17:45401833 C17orf57 -0.68 -15.07 -0.51 3.79e-44 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10208940 0.920 rs72903979 chr2:68813938 C/T cg12452813 chr2:68675892 NA 0.47 8.23 0.31 1.06e-15 Urate levels in lean individuals; BRCA cis rs72615157 0.634 rs74774557 chr7:99810425 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.63 10.83 0.39 3.23e-25 Lung function (FEV1/FVC); BRCA cis rs7264396 0.563 rs2425120 chr20:34324456 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs3824867 0.879 rs4752837 chr11:47465955 G/A cg20307385 chr11:47447363 PSMC3 0.51 11.55 0.42 3.77e-28 Mean corpuscular hemoglobin; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg16362232 chr11:430036 ANO9 0.5 8.03 0.3 4.82e-15 Body mass index; BRCA cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg08999081 chr20:33150536 PIGU -0.46 -12.62 -0.45 9.12e-33 Glomerular filtration rate (creatinine); BRCA cis rs7072216 0.727 rs7913541 chr10:100172479 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.72 -0.36 6.14e-21 Metabolite levels; BRCA cis rs7666738 0.830 rs13119995 chr4:99026790 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11890956 chr21:40555474 PSMG1 -0.62 -13.99 -0.48 5.67e-39 Menarche (age at onset); BRCA cis rs11190604 1.000 rs10883509 chr10:102296461 C/T cg07080220 chr10:102295463 HIF1AN 0.63 14.88 0.51 3.41e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2880765 0.835 rs12324277 chr15:86041735 G/A cg10818794 chr15:86012489 AKAP13 -0.31 -8.66 -0.32 3.7e-17 Coronary artery disease; BRCA cis rs7095944 0.582 rs10901823 chr10:126488660 C/T cg08799069 chr10:126477246 METTL10 -0.35 -8.46 -0.32 1.88e-16 Asthma; BRCA cis rs1891275 0.509 rs34190234 chr10:93443074 A/C cg07889827 chr10:93443413 NA -0.44 -12.54 -0.44 2.03e-32 Intelligence (multi-trait analysis); BRCA cis rs6752107 1.000 rs2289474 chr2:234181848 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.6 0.42 2.29e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg14558114 chr2:88469736 THNSL2 0.63 9.17 0.34 6.56e-19 Plasma clusterin levels; BRCA cis rs9527 0.590 rs11191540 chr10:104822809 G/C cg04362960 chr10:104952993 NT5C2 0.43 9.77 0.36 4.15e-21 Arsenic metabolism; BRCA cis rs4594175 0.926 rs114230179 chr14:51601974 C/T cg23942311 chr14:51606299 NA 0.34 8.47 0.32 1.72e-16 Cancer; BRCA cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.03 15.95 0.53 1.8e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1577917 1.000 rs6454513 chr6:86720049 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.42 11.2 0.41 1.02e-26 Response to antipsychotic treatment; BRCA cis rs7124681 0.585 rs10838773 chr11:47834346 G/A cg20307385 chr11:47447363 PSMC3 0.39 8.8 0.33 1.25e-17 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs7737355 0.853 rs593767 chr5:131043660 T/G cg06307176 chr5:131281290 NA 0.52 10.06 0.37 3.22e-22 Life satisfaction; BRCA cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg03354898 chr7:1950403 MAD1L1 -0.49 -10.65 -0.39 1.65e-24 Bipolar disorder and schizophrenia; BRCA cis rs6835098 1.000 rs6814857 chr4:174082805 T/A cg27433088 chr4:174089019 GALNT7 0.35 9.7 0.36 7.73e-21 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1372520 0.748 rs990085 chr4:90754771 A/G cg15133208 chr4:90757351 SNCA -0.43 -8.73 -0.33 2.28e-17 Neuroticism; BRCA cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.77 17.71 0.57 2.01e-57 Hip circumference adjusted for BMI; BRCA cis rs5167 0.504 rs8100120 chr19:45466058 T/C cg13119609 chr19:45449297 APOC2 0.47 12.99 0.46 1.99e-34 Blood protein levels; BRCA cis rs61931739 0.534 rs1486886 chr12:34043619 C/T cg06521331 chr12:34319734 NA -0.63 -12.2 -0.43 6.34e-31 Morning vs. evening chronotype; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg00166722 chr3:10149974 C3orf24 0.65 11.25 0.41 6.34e-27 Alzheimer's disease; BRCA cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg11890956 chr21:40555474 PSMG1 -0.81 -19.18 -0.6 4.11e-65 Cognitive function; BRCA cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg11833968 chr6:79620685 NA -0.43 -9.6 -0.35 1.8e-20 Intelligence (multi-trait analysis); BRCA cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg21252483 chr19:49399788 TULP2 -0.51 -11.09 -0.4 2.84e-26 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg24642439 chr20:33292090 TP53INP2 0.68 13.9 0.48 1.45e-38 Coronary artery disease; BRCA trans rs61931739 0.963 rs1817759 chr12:34101521 G/A cg26384229 chr12:38710491 ALG10B -0.41 -8.96 -0.33 3.4e-18 Morning vs. evening chronotype; BRCA cis rs2204008 0.557 rs11520191 chr12:38197057 T/A cg13010199 chr12:38710504 ALG10B 0.45 9.01 0.34 2.38e-18 Bladder cancer; BRCA cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg01483505 chr11:975446 AP2A2 0.33 9.07 0.34 1.44e-18 Alzheimer's disease (late onset); BRCA cis rs921968 0.510 rs620887 chr2:219465594 C/A cg10223061 chr2:219282414 VIL1 -0.28 -8.32 -0.31 5.35e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs11958404 0.932 rs12514557 chr5:157418954 T/C cg05962755 chr5:157440814 NA 0.5 9.57 0.35 2.34e-20 IgG glycosylation; BRCA cis rs10751667 0.621 rs10794351 chr11:946228 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.71 0.55 2.67e-52 Alzheimer's disease (late onset); BRCA trans rs7939886 0.764 rs79601668 chr11:55753767 G/C cg15704280 chr7:45808275 SEPT13 0.62 7.94 0.3 9.08e-15 Myopia (pathological); BRCA cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg11266682 chr4:10021025 SLC2A9 0.5 13.16 0.46 3.48e-35 Bone mineral density; BRCA cis rs4845875 0.626 rs12734761 chr1:11834182 G/A cg24844545 chr1:11908347 NPPA 0.31 7.95 0.3 8.34e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg18357645 chr12:58087776 OS9 -0.34 -8.22 -0.31 1.1e-15 Multiple sclerosis; BRCA cis rs4481887 0.861 rs7412034 chr1:248434150 G/C cg00666640 chr1:248458726 OR2T12 0.28 7.94 0.3 9.22e-15 Common traits (Other); BRCA cis rs1707322 0.752 rs61784798 chr1:46173481 C/T cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 1.000 rs1768801 chr1:46549137 C/G cg06784218 chr1:46089804 CCDC17 -0.44 -10.47 -0.38 8.95e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.862 rs4368860 chr7:65608482 C/G cg18876405 chr7:65276391 NA -0.51 -11.78 -0.42 3.9e-29 Aortic root size; BRCA cis rs4363385 0.747 rs2879489 chr1:152970465 A/G cg21543102 chr1:152974771 SPRR3 -0.28 -8.04 -0.3 4.2e-15 Inflammatory skin disease; BRCA cis rs2276314 0.947 rs4799831 chr18:33554775 A/G cg19628046 chr18:33552617 C18orf21 0.59 11.78 0.42 3.86e-29 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg00149659 chr3:10157352 C3orf10 0.79 13.83 0.48 2.94e-38 Alzheimer's disease; BRCA cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4148883 0.737 rs13148577 chr4:100060836 G/A cg13256891 chr4:100009986 ADH5 0.38 8.04 0.3 4.36e-15 Alcohol dependence; BRCA cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg24006582 chr15:45444508 DUOX1 0.54 10.72 0.39 9.21e-25 Uric acid levels; BRCA cis rs7301826 0.651 rs7968675 chr12:131303377 C/T cg11011512 chr12:131303247 STX2 0.53 14.01 0.48 4.53e-39 Plasma plasminogen activator levels; BRCA cis rs12200782 0.505 rs1535275 chr6:26520767 G/C cg09904177 chr6:26538194 HMGN4 0.41 9.29 0.34 2.48e-19 Small cell lung carcinoma; BRCA cis rs10751667 0.666 rs7395321 chr11:940280 C/T cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs1707322 0.685 rs11211177 chr1:46226349 A/G cg06784218 chr1:46089804 CCDC17 0.49 11.33 0.41 2.91e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9325144 0.650 rs6582624 chr12:38733475 A/T cg13010199 chr12:38710504 ALG10B -0.38 -8.36 -0.31 4.03e-16 Morning vs. evening chronotype; BRCA cis rs7714584 1.000 rs931058 chr5:150333698 A/T cg22134413 chr5:150180641 NA 0.75 10.24 0.38 6.66e-23 Crohn's disease; BRCA cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.23 0.31 1.05e-15 Cognitive ability; BRCA cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg05868516 chr6:26286170 HIST1H4H 0.49 10.85 0.39 2.67e-25 Educational attainment; BRCA cis rs4906332 1.000 rs3783397 chr14:103947289 A/G cg04998671 chr14:104000505 TRMT61A -0.43 -9.74 -0.36 5.2e-21 Coronary artery disease; BRCA cis rs12950390 0.893 rs4239165 chr17:45847272 A/T cg24803719 chr17:45855879 NA -0.32 -8.54 -0.32 9.76e-17 IgG glycosylation; BRCA cis rs875971 1.000 rs6961990 chr7:65888570 C/A cg18876405 chr7:65276391 NA 0.56 13.15 0.46 3.81e-35 Aortic root size; BRCA cis rs12142240 0.698 rs966907 chr1:46817125 C/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs9325144 0.647 rs34963631 chr12:38912260 T/A cg26384229 chr12:38710491 ALG10B -0.51 -12.31 -0.44 2.05e-31 Morning vs. evening chronotype; BRCA cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg02187348 chr16:89574699 SPG7 0.54 13.02 0.46 1.54e-34 Multiple myeloma (IgH translocation); BRCA cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg21475434 chr5:93447410 FAM172A 0.67 8.74 0.33 2.03e-17 Diabetic retinopathy; BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg27170947 chr2:26402098 FAM59B 0.95 15.52 0.52 2.53e-46 Gut microbiome composition (summer); BRCA trans rs10506458 1.000 rs73127086 chr12:63415626 G/A cg22491629 chr6:157744540 C6orf35 -0.64 -12.21 -0.43 5.86e-31 Hemostatic factors and hematological phenotypes; BRCA cis rs6121246 0.511 rs879982 chr20:30398510 A/G cg21427119 chr20:30132790 HM13 -0.35 -7.99 -0.3 6.19e-15 Mean corpuscular hemoglobin; BRCA cis rs7647973 0.621 rs3774800 chr3:49334768 A/G cg07636037 chr3:49044803 WDR6 -0.76 -18.46 -0.59 2.75e-61 Menarche (age at onset); BRCA cis rs1018836 0.923 rs13255452 chr8:91582988 A/G cg16814680 chr8:91681699 NA -0.58 -12.42 -0.44 6.93e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6138458 1.000 rs1977540 chr20:24900290 G/T cg06937882 chr20:24974362 C20orf3 0.44 8.35 0.31 4.34e-16 Blood protein levels; BRCA cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg22974920 chr21:40686053 BRWD1 -0.35 -7.84 -0.3 1.85e-14 Menarche (age at onset); BRCA cis rs911555 0.662 rs4906322 chr14:103879032 A/G cg12935359 chr14:103987150 CKB 0.61 13.88 0.48 1.79e-38 Intelligence (multi-trait analysis); BRCA cis rs7568458 0.660 rs6547623 chr2:85801964 T/A cg02493740 chr2:85810744 VAMP5 -0.56 -11.85 -0.42 1.92e-29 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2072499 0.966 rs2842882 chr1:156165342 T/G cg06970220 chr1:156163860 SLC25A44 0.4 9.58 0.35 2.04e-20 Testicular germ cell tumor; BRCA cis rs62064224 0.714 rs11657299 chr17:30634951 G/A cg18200150 chr17:30822561 MYO1D 0.35 9.0 0.34 2.6e-18 Schizophrenia; BRCA cis rs7737355 0.645 rs7731071 chr5:130973483 A/G cg06307176 chr5:131281290 NA 0.53 10.35 0.38 2.57e-23 Life satisfaction; BRCA cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg11279151 chr3:101281821 RG9MTD1 -0.35 -8.11 -0.31 2.59e-15 Colorectal cancer; BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg22800045 chr5:56110881 MAP3K1 0.63 11.9 0.43 1.23e-29 Initial pursuit acceleration; BRCA cis rs2404602 0.647 rs3812908 chr15:77176158 C/T cg23625390 chr15:77176239 SCAPER 0.54 14.03 0.49 3.58e-39 Blood metabolite levels; BRCA cis rs897984 0.806 rs1046276 chr16:30914626 A/G cg02466173 chr16:30829666 NA 0.49 11.27 0.41 5.58e-27 Dementia with Lewy bodies; BRCA cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14829155 chr15:31115871 NA -0.56 -13.17 -0.46 3.25e-35 Huntington's disease progression; BRCA cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg25174290 chr11:3078921 CARS 0.42 12.03 0.43 3.3e-30 Longevity; BRCA cis rs2836974 0.897 rs8132568 chr21:40527916 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.88 0.62 8.28e-69 Cognitive function; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg05863683 chr7:1912471 MAD1L1 0.37 8.2 0.31 1.31e-15 Bipolar disorder and schizophrenia; BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.06 0.62 8.33e-70 Platelet count; BRCA cis rs10504229 1.000 rs73609762 chr8:58192695 A/G cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs1953600 0.870 rs2236557 chr10:81923961 A/G cg04850286 chr10:81895943 PLAC9 0.31 8.65 0.32 4e-17 Sarcoidosis; BRCA cis rs6831352 1.000 rs1126671 chr4:100048414 T/C cg13256891 chr4:100009986 ADH5 0.47 9.06 0.34 1.52e-18 Alcohol dependence; BRCA trans rs9393777 0.920 rs13195040 chr6:27413924 C/T cg01620082 chr3:125678407 NA 0.76 9.63 0.36 1.36e-20 Intelligence (multi-trait analysis); BRCA cis rs67478160 0.595 rs12433109 chr14:104196607 G/A cg01849466 chr14:104193079 ZFYVE21 -0.47 -11.81 -0.42 3.09e-29 Schizophrenia; BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg24060327 chr5:131705240 SLC22A5 -0.46 -9.15 -0.34 7.57e-19 Acylcarnitine levels; BRCA trans rs11098499 0.913 rs56122576 chr4:120129336 A/G cg25214090 chr10:38739885 LOC399744 0.53 10.77 0.39 5.54e-25 Corneal astigmatism; BRCA cis rs698833 0.508 rs698765 chr2:44573671 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.36 0.38 2.27e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs3820928 0.874 rs7423610 chr2:227836262 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.34 -0.31 4.47e-16 Pulmonary function; BRCA cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg11062466 chr8:58055876 NA 0.41 7.94 0.3 9.37e-15 Developmental language disorder (linguistic errors); BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg09177884 chr7:1199841 ZFAND2A -0.41 -7.91 -0.3 1.13e-14 Bronchopulmonary dysplasia; BRCA cis rs760805 1.000 rs10903115 chr1:25261696 A/G cg22509179 chr1:25234806 RUNX3 -0.57 -14.82 -0.51 6.64e-43 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6138458 1.000 rs227615 chr20:24908721 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.76 0.7 2.17e-95 Blood protein levels; BRCA cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.22 0.34 4.41e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs12701220 0.894 rs8591 chr7:1036799 C/T cg06145435 chr7:1022769 CYP2W1 0.49 9.15 0.34 7.7e-19 Bronchopulmonary dysplasia; BRCA trans rs4596713 0.568 rs10124710 chr9:71748279 G/A cg16512924 chr15:28394682 HERC2 0.42 9.99 0.37 5.96e-22 Headache; BRCA cis rs10129255 0.518 rs12590732 chr14:107187851 C/T cg07958169 chr14:107095056 NA 0.38 8.2 0.31 1.31e-15 Kawasaki disease; BRCA cis rs67460515 0.892 rs34016896 chr3:160992864 C/T cg04691961 chr3:161091175 C3orf57 -0.37 -7.9 -0.3 1.21e-14 Parkinson's disease; BRCA cis rs4730250 0.707 rs257373 chr7:106798290 G/A cg02696742 chr7:106810147 HBP1 -0.59 -9.66 -0.36 1.09e-20 Osteoarthritis; BRCA cis rs4853036 0.629 rs10210787 chr2:70016053 C/T cg02498382 chr2:70120550 SNRNP27 -0.44 -8.19 -0.31 1.41e-15 Colorectal or endometrial cancer; BRCA cis rs853679 0.517 rs36078605 chr6:28078032 A/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.32 -0.31 5.29e-16 Depression; BRCA cis rs7572733 0.534 rs1464209 chr2:198814396 A/G cg00792783 chr2:198669748 PLCL1 0.45 9.89 0.36 1.47e-21 Dermatomyositis; BRCA cis rs11098499 0.644 rs3806808 chr4:120551085 A/C cg09307838 chr4:120376055 NA 0.59 12.37 0.44 1.19e-31 Corneal astigmatism; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.2 0.43 6.34e-31 Platelet count; BRCA cis rs897080 0.515 rs1067334 chr2:44626633 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.37 0.35 1.23e-19 Height; BRCA cis rs813218 0.527 rs793450 chr3:99532532 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -8.64 -0.32 4.57e-17 Orofacial clefts; BRCA cis rs12714314 0.830 rs10207910 chr2:1963781 T/C cg22511877 chr2:1942942 MYT1L 0.39 8.2 0.31 1.36e-15 Type 2 diabetes (age of onset); BRCA cis rs6977660 1.000 rs12672557 chr7:19804237 G/A cg07541023 chr7:19748670 TWISTNB 0.44 7.92 0.3 1.04e-14 Thyroid stimulating hormone; BRCA cis rs7953508 0.506 rs2200160 chr12:93963873 C/T cg18151635 chr12:93972918 NA -0.45 -8.98 -0.33 2.92e-18 Pubertal anthropometrics; BRCA cis rs35110281 0.666 rs2838348 chr21:45107285 C/G cg04455712 chr21:45112962 RRP1B -0.43 -10.83 -0.39 3.25e-25 Mean corpuscular volume; BRCA cis rs2066819 1.000 rs79824801 chr12:56728137 T/C cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.02 15.64 0.53 6.41e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg24549020 chr5:56110836 MAP3K1 -0.38 -8.01 -0.3 5.4e-15 Initial pursuit acceleration; BRCA cis rs12926788 0.546 rs200537 chr16:24747787 G/C cg06028605 chr16:24865363 SLC5A11 -0.47 -10.23 -0.38 7.54e-23 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs501916 0.634 rs10851459 chr15:48061510 C/A cg16110827 chr15:48056943 SEMA6D -0.43 -9.08 -0.34 1.29e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg04553112 chr3:125709451 NA -0.55 -8.34 -0.31 4.47e-16 Blood pressure (smoking interaction); BRCA cis rs523522 0.962 rs509445 chr12:121017243 A/C cg27279351 chr12:120934652 DYNLL1 0.56 13.24 0.46 1.62e-35 High light scatter reticulocyte count; BRCA cis rs6545883 0.860 rs6545847 chr2:61445333 C/T cg15711740 chr2:61764176 XPO1 0.52 13.13 0.46 4.85e-35 Tuberculosis; BRCA cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg02734326 chr4:10020555 SLC2A9 0.35 7.82 0.3 2.11e-14 Bone mineral density; BRCA cis rs1552244 1.000 rs61052895 chr3:10147516 G/A cg08888203 chr3:10149979 C3orf24 0.67 14.09 0.49 1.89e-39 Alzheimer's disease; BRCA cis rs12477438 0.798 rs10198293 chr2:99602929 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.81 -0.58 6.55e-58 Chronic sinus infection; BRCA cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg01028140 chr2:1542097 TPO -0.56 -11.88 -0.43 1.5e-29 IgG glycosylation; BRCA cis rs2836974 0.829 rs34227163 chr21:40551943 A/G cg17971929 chr21:40555470 PSMG1 0.77 18.23 0.58 4.34e-60 Cognitive function; BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg02951883 chr7:2050386 MAD1L1 -0.55 -12.93 -0.46 3.8e-34 Bipolar disorder and schizophrenia; BRCA cis rs6878727 0.850 rs1363308 chr5:123707222 A/G cg01806427 chr5:123737813 NA 0.4 9.36 0.35 1.39e-19 Breast cancer; BRCA cis rs644148 0.836 rs2686775 chr19:45000059 C/T cg15540054 chr19:45004280 ZNF180 -0.57 -12.31 -0.44 2.15e-31 Personality dimensions; BRCA cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg18305652 chr10:134549665 INPP5A 0.5 11.51 0.41 5.37e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs365132 0.875 rs187114 chr5:176364039 A/G cg16309518 chr5:176445507 NA -0.41 -10.0 -0.37 5.89e-22 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2051211 1.000 rs2051211 chr3:38559749 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.5 -10.18 -0.37 1.2e-22 QRS duration; BRCA cis rs2816062 0.813 rs2816040 chr1:18889536 C/T cg18795169 chr1:18902165 NA 0.97 29.55 0.76 1.3e-121 Urate levels in lean individuals; BRCA cis rs13136331 0.641 rs2627682 chr4:88662490 A/G cg12990093 chr4:88570587 DMP1 -0.4 -8.22 -0.31 1.17e-15 Sitting height ratio; BRCA cis rs74417235 0.517 rs13179034 chr5:154059487 C/A cg08754654 chr5:154026448 NA 0.43 9.87 0.36 1.72e-21 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs2180341 1.000 rs9388561 chr6:127634921 C/T cg27446573 chr6:127587934 RNF146 0.9 21.19 0.64 6.68e-76 Breast cancer; BRCA cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.83 -0.3 2.08e-14 Electroencephalogram traits; BRCA cis rs2882667 0.690 rs167009 chr5:138200457 G/C cg04439458 chr5:138467593 SIL1 0.35 8.55 0.32 9.12e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs875971 0.964 rs778708 chr7:65856319 T/C cg18876405 chr7:65276391 NA 0.55 13.31 0.47 7.25e-36 Aortic root size; BRCA cis rs6088590 1.000 rs2180276 chr20:33360785 T/A cg24642439 chr20:33292090 TP53INP2 0.7 15.97 0.53 1.41e-48 Coronary artery disease; BRCA cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg24642439 chr20:33292090 TP53INP2 0.41 8.09 0.3 3.03e-15 Height; BRCA cis rs7666738 0.830 rs2114426 chr4:98933130 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7833986 0.501 rs17815934 chr8:57038395 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.06 0.46 9.86e-35 Height; BRCA cis rs6121246 0.559 rs12479491 chr20:30265450 T/C cg21427119 chr20:30132790 HM13 -0.35 -8.06 -0.3 3.7e-15 Mean corpuscular hemoglobin; BRCA cis rs3862030 0.500 rs11191327 chr10:104303883 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.24 0.63 8.98e-71 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs7267979 1.000 rs2297497 chr20:25297909 C/T cg08601574 chr20:25228251 PYGB -0.36 -8.67 -0.32 3.48e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6542838 0.702 rs4851177 chr2:99535188 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -9.35 -0.35 1.51e-19 Fear of minor pain; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg09436375 chr6:42928200 GNMT -0.28 -10.61 -0.39 2.38e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2245008 0.671 rs907036 chr16:83989850 A/T cg27171569 chr16:83987465 OSGIN1 0.42 12.31 0.44 2.16e-31 Pursuit maintenance gain; BRCA cis rs1395 0.744 rs11126935 chr2:27476740 G/T cg23587288 chr2:27483067 SLC30A3 -0.38 -8.9 -0.33 5.91e-18 Blood metabolite levels; BRCA cis rs312273 0.590 rs278920 chr12:41377914 T/G cg17827154 chr12:41323612 CNTN1 -0.39 -10.2 -0.37 1.02e-22 Bipolar disorder; BRCA cis rs11098499 0.779 rs28495013 chr4:120375831 A/C cg09307838 chr4:120376055 NA 0.74 16.14 0.54 2.13e-49 Corneal astigmatism; BRCA cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2991971 0.967 rs2356551 chr1:46009318 C/T cg24296786 chr1:45957014 TESK2 0.65 16.1 0.54 3.21e-49 High light scatter reticulocyte count; BRCA cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg16405210 chr4:1374714 KIAA1530 -0.4 -8.69 -0.33 3e-17 Obesity-related traits; BRCA cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg02734326 chr4:10020555 SLC2A9 0.38 8.2 0.31 1.28e-15 Bone mineral density; BRCA cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg01304814 chr3:48885189 PRKAR2A 0.57 7.91 0.3 1.11e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs1801251 0.778 rs2675957 chr2:233754364 C/T cg08000102 chr2:233561755 GIGYF2 -0.46 -10.05 -0.37 3.72e-22 Coronary artery disease; BRCA cis rs9300255 0.510 rs1727322 chr12:123699520 A/G cg00376283 chr12:123451042 ABCB9 0.55 10.54 0.38 4.47e-24 Neutrophil percentage of white cells; BRCA cis rs1008375 0.863 rs4590022 chr4:17614434 T/C cg02297831 chr4:17616191 MED28 0.37 8.61 0.32 5.47e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.51 12.3 0.44 2.24e-31 Response to bleomycin (chromatid breaks); BRCA cis rs1580019 0.539 rs11769109 chr7:32571352 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.57 0.76 9.97e-122 Cognitive ability; BRCA cis rs1710278 0.935 rs898319 chr10:127746372 C/T cg22975853 chr10:127789788 ADAM12 0.33 8.52 0.32 1.16e-16 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs6901250 0.851 rs339361 chr6:117162515 C/T cg12892004 chr6:117198278 RFX6 0.48 11.09 0.4 2.96e-26 C-reactive protein levels; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg03188948 chr7:1209495 NA 0.58 11.11 0.4 2.54e-26 Longevity;Endometriosis; BRCA cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg05025164 chr4:1340916 KIAA1530 -0.63 -12.7 -0.45 3.94e-33 Obesity-related traits; BRCA cis rs7178424 0.935 rs8032433 chr15:62284101 A/G cg00456672 chr15:62358751 C2CD4A -0.38 -8.66 -0.32 3.72e-17 Height; BRCA cis rs1003719 0.680 rs3737540 chr21:38523266 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.54 -12.29 -0.44 2.55e-31 Eye color traits; BRCA cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.43 8.26 0.31 8.63e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs7172677 0.737 rs4886668 chr15:75448034 T/C cg14664628 chr15:75095509 CSK -0.42 -9.02 -0.34 2.13e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs9369695 0.842 rs2396825 chr6:47568696 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.56 0.35 2.56e-20 Reticulocyte count; BRCA cis rs9875589 0.509 rs1844107 chr3:14065319 C/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.95 0.33 3.85e-18 Ovarian reserve; BRCA cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs10927875 0.662 rs848309 chr1:16308447 T/C cg06159980 chr1:16340746 HSPB7 -0.33 -7.81 -0.3 2.33e-14 Dilated cardiomyopathy; BRCA cis rs2073300 0.609 rs6137937 chr20:23385419 G/A cg12062639 chr20:23401060 NAPB 0.95 13.22 0.46 1.89e-35 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.81 13.3 0.47 8.13e-36 Platelet count; BRCA cis rs6815814 0.950 rs11722813 chr4:38810769 C/T cg02016764 chr4:38805732 TLR1 -0.62 -9.69 -0.36 8.13e-21 Breast cancer; BRCA cis rs611744 0.647 rs7016198 chr8:109262752 G/A cg21045802 chr8:109455806 TTC35 0.34 7.87 0.3 1.52e-14 Dupuytren's disease; BRCA cis rs7789940 1.000 rs76024966 chr7:75995021 C/T cg10167463 chr7:75959203 YWHAG -0.44 -8.69 -0.33 3e-17 Multiple sclerosis; BRCA cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.4 0.38 1.71e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs17125944 0.572 rs79312783 chr14:53250296 A/T cg00686598 chr14:53173677 PSMC6 1.16 15.74 0.53 2.07e-47 Alzheimer's disease (late onset); BRCA cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg15017067 chr4:17643749 FAM184B 0.26 7.81 0.3 2.27e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10197940 0.578 rs1061305 chr2:152346979 T/C cg06191203 chr2:152266755 RIF1 -0.28 -8.12 -0.31 2.41e-15 Lung cancer; BRCA cis rs881375 0.935 rs7034390 chr9:123646488 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 11.11 0.4 2.5e-26 Rheumatoid arthritis; BRCA cis rs67478160 0.595 rs12889993 chr14:104274294 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.5 -0.32 1.38e-16 Schizophrenia; BRCA cis rs6582630 0.555 rs7978749 chr12:38527141 G/T cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 8.15e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs6089829 0.855 rs4809459 chr20:61661345 C/T cg08564027 chr20:61660810 NA 0.85 22.66 0.67 6.95e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs9790314 0.967 rs339101 chr3:161064193 A/T cg03342759 chr3:160939853 NMD3 -0.62 -12.96 -0.46 2.75e-34 Morning vs. evening chronotype; BRCA cis rs6772849 0.796 rs9841521 chr3:128392274 A/G cg16766828 chr3:128327626 NA -0.41 -8.79 -0.33 1.34e-17 Monocyte percentage of white cells;Monocyte count; BRCA trans rs61931739 0.500 rs7307583 chr12:34521711 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.54 0.47 6.37e-37 Morning vs. evening chronotype; BRCA cis rs921968 0.565 rs6733892 chr2:219616002 C/A cg02176678 chr2:219576539 TTLL4 -0.42 -11.67 -0.42 1.21e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs2882667 0.690 rs288035 chr5:138212417 A/T cg04439458 chr5:138467593 SIL1 -0.35 -8.56 -0.32 8.34e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs1493916 0.601 rs7237379 chr18:31322540 C/T cg27147174 chr7:100797783 AP1S1 0.47 9.48 0.35 4.69e-20 Life satisfaction; BRCA cis rs13118159 0.801 rs10024996 chr4:1328297 G/A cg16405210 chr4:1374714 KIAA1530 -0.43 -9.64 -0.36 1.25e-20 Longevity; BRCA cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.1 0.46 6.77e-35 Schizophrenia; BRCA cis rs6060717 0.536 rs6058356 chr20:34491530 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -8.06 -0.3 3.8e-15 Hip circumference adjusted for BMI; BRCA cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.12 0.31 2.41e-15 Parkinson's disease; BRCA cis rs6964587 1.000 rs7785095 chr7:91640773 A/T cg17063962 chr7:91808500 NA -0.53 -12.43 -0.44 6.48e-32 Breast cancer; BRCA cis rs1448094 0.512 rs6539929 chr12:86244932 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.28 -0.34 2.49e-19 Major depressive disorder; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg02951883 chr7:2050386 MAD1L1 -0.49 -10.84 -0.39 2.98e-25 Bipolar disorder and schizophrenia; BRCA cis rs2425143 1.000 rs57963833 chr20:34344225 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.64 -9.02 -0.34 2.18e-18 Blood protein levels; BRCA cis rs116095464 0.558 rs10056628 chr5:279512 G/A cg22496380 chr5:211416 CCDC127 -1.0 -14.24 -0.49 3.65e-40 Breast cancer; BRCA trans rs208515 0.525 rs1484577 chr6:66688397 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.8 15.45 0.52 5.66e-46 Exhaled nitric oxide levels; BRCA cis rs4268898 0.636 rs72787371 chr2:24570073 T/A cg06627628 chr2:24431161 ITSN2 -0.8 -15.16 -0.51 1.4e-44 Asthma; BRCA cis rs9986765 1.000 rs76467433 chr7:142824852 C/T cg15652212 chr7:142981776 TMEM139 0.63 9.92 0.37 1.16e-21 Cancer;Dermatomyositis; BRCA cis rs6772849 0.896 rs4557179 chr3:128366726 A/C cg16766828 chr3:128327626 NA -0.4 -8.77 -0.33 1.68e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs778371 0.723 rs2592104 chr2:233645970 G/A cg08000102 chr2:233561755 GIGYF2 0.81 18.91 0.6 1.19e-63 Schizophrenia; BRCA cis rs4722166 0.597 rs1554606 chr7:22768707 T/G cg05472934 chr7:22766657 IL6 0.52 13.77 0.48 5.71e-38 Lung cancer; BRCA cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 29.89 0.76 1.71e-123 Cognitive ability; BRCA cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg13010199 chr12:38710504 ALG10B -0.4 -8.56 -0.32 8.56e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs3820928 0.874 rs10933165 chr2:227883648 C/G cg11843606 chr2:227700838 RHBDD1 0.38 8.34 0.31 4.55e-16 Pulmonary function; BRCA trans rs11764590 0.715 rs11760737 chr7:2104055 T/C cg11693508 chr17:37793320 STARD3 0.51 8.98 0.33 3.01e-18 Neuroticism; BRCA cis rs2204008 0.744 rs67889662 chr12:38327042 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.09 0.37 2.48e-22 Bladder cancer; BRCA cis rs6582630 0.519 rs7294292 chr12:38349540 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.32 0.57 2.11e-55 Drug-induced liver injury (flucloxacillin); BRCA trans rs3857536 0.813 rs6904511 chr6:66939102 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs965469 0.779 rs6037568 chr20:3333245 C/T cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA cis rs2806561 0.514 rs11801120 chr1:23543307 C/T cg24466277 chr1:23519622 HTR1D -0.4 -8.68 -0.32 3.22e-17 Height; BRCA cis rs6831352 0.918 rs34936974 chr4:100052384 A/G cg12011299 chr4:100065546 ADH4 0.46 11.16 0.4 1.57e-26 Alcohol dependence; BRCA cis rs796364 0.806 rs74266490 chr2:201005995 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA cis rs7267979 0.966 rs6050611 chr20:25414419 A/G cg08601574 chr20:25228251 PYGB 0.36 8.51 0.32 1.27e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg25809561 chr17:30822961 MYO1D -0.51 -12.36 -0.44 1.23e-31 Schizophrenia; BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.29 -0.47 9.55e-36 Platelet count; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg24846343 chr22:24311635 DDTL 0.57 14.85 0.51 4.33e-43 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs12530845 0.673 rs4269479 chr7:135332379 C/T cg23117316 chr7:135346802 PL-5283 -0.39 -8.02 -0.3 5.07e-15 Red blood cell traits; BRCA cis rs870825 0.616 rs6552808 chr4:185642865 G/T cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.67 -13.35 -0.47 4.9e-36 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11711311 1.000 rs9826465 chr3:113432254 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -10.45 -0.38 1.07e-23 IgG glycosylation; BRCA cis rs11608355 0.515 rs11613718 chr12:109912332 C/T cg05360138 chr12:110035743 NA 0.69 12.69 0.45 4.46e-33 Neuroticism; BRCA cis rs3806843 0.735 rs801183 chr5:140091115 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.45 -10.66 -0.39 1.62e-24 Depressive symptoms (multi-trait analysis); BRCA cis rs881375 0.526 rs1930785 chr9:123691237 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.37 7.8 0.3 2.45e-14 Rheumatoid arthritis; BRCA cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg06484146 chr7:12443880 VWDE -0.72 -10.73 -0.39 8.24e-25 Coronary artery disease; BRCA cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg14983838 chr19:29218262 NA 0.57 11.56 0.42 3.42e-28 Methadone dose in opioid dependence; BRCA cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg02475777 chr4:1388615 CRIPAK 0.37 8.1 0.31 2.7e-15 Longevity; BRCA trans rs7829975 0.688 rs7826660 chr8:8379107 C/A cg21775007 chr8:11205619 TDH 0.43 8.78 0.33 1.5e-17 Mood instability; BRCA cis rs7267979 1.000 rs6050629 chr20:25430680 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs7524258 0.868 rs4908451 chr1:7299618 C/G cg07173049 chr1:7289937 CAMTA1 -0.53 -12.95 -0.46 3.22e-34 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs11098499 0.731 rs6846966 chr4:120293208 A/G cg09307838 chr4:120376055 NA 0.66 14.25 0.49 3.43e-40 Corneal astigmatism; BRCA cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs478304 0.934 rs12801731 chr11:65549606 T/C cg08755490 chr11:65554678 OVOL1 0.54 11.17 0.4 1.34e-26 Acne (severe); BRCA cis rs61990749 0.597 rs2364584 chr14:78152286 T/C cg23188588 chr14:78226832 SNW1;C14orf178 -0.44 -7.91 -0.3 1.17e-14 Fibroblast growth factor basic levels; BRCA cis rs7100689 0.577 rs10749560 chr10:82092801 G/T cg01528321 chr10:82214614 TSPAN14 0.81 17.34 0.57 1.76e-55 Post bronchodilator FEV1; BRCA cis rs473651 0.935 rs515412 chr2:239345394 A/T cg18131467 chr2:239335373 ASB1 0.92 31.46 0.78 6.35e-132 Multiple system atrophy; BRCA cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg23711669 chr6:146136114 FBXO30 0.75 17.23 0.56 6.5e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs3093024 1.000 rs3093024 chr6:167532793 C/T cg07741184 chr6:167504864 NA 0.28 8.4 0.32 2.81e-16 Rheumatoid arthritis; BRCA cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs2327062 chr6:8453858 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs9388451 0.839 rs9321054 chr6:126079968 A/G cg05901451 chr6:126070800 HEY2 0.7 20.3 0.63 4.35e-71 Brugada syndrome; BRCA cis rs6545883 0.929 rs778154 chr2:61646631 T/C cg15711740 chr2:61764176 XPO1 0.55 13.48 0.47 1.28e-36 Tuberculosis; BRCA cis rs11711311 0.747 rs11928494 chr3:113343219 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.41 -8.75 -0.33 1.83e-17 IgG glycosylation; BRCA cis rs2836950 0.545 rs11700449 chr21:40522419 A/T cg11644478 chr21:40555479 PSMG1 -0.52 -11.05 -0.4 4.13e-26 Menarche (age at onset); BRCA trans rs10242455 0.702 rs73711280 chr7:99039604 C/T cg09045935 chr12:6379348 NA 0.84 8.26 0.31 8.16e-16 Blood metabolite levels; BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs7662987 0.517 rs2602880 chr4:100040653 C/T cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs4664304 0.710 rs9636280 chr2:160717852 C/T cg02280532 chr2:160761244 LY75 -0.35 -7.83 -0.3 2.07e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1371614 0.632 rs3739088 chr2:27167784 C/T cg00617064 chr2:27272375 NA 0.32 8.29 0.31 6.53e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4808199 0.948 rs11085261 chr19:19462606 G/A cg03709012 chr19:19516395 GATAD2A 0.91 17.64 0.57 4.93e-57 Nonalcoholic fatty liver disease; BRCA cis rs4665809 1.000 rs13030858 chr2:26315451 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.64 -11.94 -0.43 7.99e-30 Gut microbiome composition (summer); BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.86 -14.51 -0.5 1.88e-41 Alzheimer's disease; BRCA cis rs6582630 0.502 rs11181210 chr12:38298069 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.4 0.38 1.62e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs17601876 0.814 rs11636639 chr15:51563092 T/G cg19946085 chr15:51559439 CYP19A1 -0.39 -11.65 -0.42 1.43e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs875971 0.651 rs313829 chr7:65552497 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -8.35 -0.31 4.39e-16 Aortic root size; BRCA cis rs1003719 0.715 rs2835657 chr21:38565064 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.44 -0.5 4.29e-41 Eye color traits; BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg25036284 chr2:26402008 FAM59B -0.77 -12.12 -0.43 1.42e-30 Gut microbiome composition (summer); BRCA cis rs9486719 1.000 rs12193732 chr6:96942609 G/A cg06623918 chr6:96969491 KIAA0776 -0.73 -13.08 -0.46 8.41e-35 Migraine;Coronary artery disease; BRCA cis rs7264396 0.790 rs2425097 chr20:34308926 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.15 0.31 1.93e-15 Total cholesterol levels; BRCA cis rs7666738 0.716 rs6814353 chr4:99074202 A/G cg05340658 chr4:99064831 C4orf37 0.66 15.53 0.52 2.34e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg10295955 chr4:187884368 NA -0.99 -30.95 -0.77 3.18e-129 Lobe attachment (rater-scored or self-reported); BRCA trans rs3780486 0.846 rs3780490 chr9:33129839 A/G cg20290983 chr6:43655470 MRPS18A 1.1 40.85 0.85 2.33e-180 IgG glycosylation; BRCA cis rs9487051 0.708 rs378447 chr6:109526823 G/A cg21918786 chr6:109611834 NA -0.34 -8.97 -0.33 3.3e-18 Reticulocyte fraction of red cells; BRCA cis rs9291683 0.588 rs13133766 chr4:10019732 C/T cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.74e-18 Bone mineral density; BRCA trans rs4714291 0.963 rs1304602 chr6:40013471 T/G cg02267698 chr19:7991119 CTXN1 0.4 7.85 0.3 1.71e-14 Strep throat; BRCA cis rs9814567 1.000 rs9884031 chr3:134256500 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.78 -0.33 1.45e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6942756 0.806 rs10257620 chr7:128901429 C/A cg02491457 chr7:128862824 NA 0.59 12.56 0.45 1.63e-32 White matter hyperintensity burden; BRCA cis rs9393692 0.905 rs4412192 chr6:26290377 A/G cg13736514 chr6:26305472 NA 0.35 11.81 0.42 2.95e-29 Educational attainment; BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs796364 0.806 rs203766 chr2:200902672 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.45 -0.38 1.09e-23 Schizophrenia; BRCA cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg20887711 chr4:1340912 KIAA1530 0.59 13.25 0.46 1.42e-35 Longevity; BRCA cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg20476274 chr7:133979776 SLC35B4 0.65 19.38 0.61 3.63e-66 Mean platelet volume; BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg13047869 chr3:10149882 C3orf24 -0.55 -10.18 -0.37 1.16e-22 Alzheimer's disease; BRCA trans rs877282 1.000 rs71491304 chr10:772982 C/T cg22713356 chr15:30763199 NA 1.19 24.18 0.69 3.39e-92 Uric acid levels; BRCA cis rs10752881 1.000 rs10737235 chr1:182971816 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 17.04 0.56 5.99e-54 Colorectal cancer; BRCA cis rs7592578 0.766 rs62182865 chr2:191434180 T/C cg10560079 chr2:191398806 TMEM194B -0.77 -13.14 -0.46 4.64e-35 Diastolic blood pressure; BRCA cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg14847009 chr1:175162515 KIAA0040 0.25 9.65 0.36 1.14e-20 Diastolic blood pressure; BRCA cis rs10911232 0.507 rs7515822 chr1:183037803 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.47 0.55 4.76e-51 Hypertriglyceridemia; BRCA cis rs3771570 1.000 rs12619369 chr2:242282957 A/T cg21155796 chr2:242212141 HDLBP 0.54 8.99 0.33 2.83e-18 Prostate cancer; BRCA cis rs3806843 0.932 rs2563256 chr5:140141779 G/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.51 0.35 3.8e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs13392177 0.684 rs11695527 chr2:219068103 A/G cg00012203 chr2:219082015 ARPC2 0.51 10.54 0.38 4.58e-24 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs6138458 1.000 rs227615 chr20:24908721 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.38 -0.31 3.34e-16 Blood protein levels; BRCA cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.39 0.49 7.08e-41 Motion sickness; BRCA cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs11098499 0.866 rs9995136 chr4:120286845 A/G cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs7666738 0.830 rs9998803 chr4:99002519 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg06468780 chr21:31798236 KRTAP13-3 0.37 9.38 0.35 1.11e-19 HDL cholesterol; BRCA cis rs11676348 0.714 rs4674254 chr2:218986077 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.97 -0.3 7.2e-15 Ulcerative colitis; BRCA cis rs4285028 0.747 rs9808981 chr3:121429561 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.97 -0.48 6.66e-39 Multiple sclerosis; BRCA cis rs7618501 0.633 rs6772095 chr3:49978069 C/T cg24110177 chr3:50126178 RBM5 -0.36 -9.59 -0.35 1.96e-20 Intelligence (multi-trait analysis); BRCA cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg00074818 chr8:8560427 CLDN23 0.35 7.88 0.3 1.45e-14 Obesity-related traits; BRCA cis rs1829883 0.835 rs2682139 chr5:98909924 G/A cg08333243 chr5:99726346 NA 0.36 8.48 0.32 1.62e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs6426558 0.514 rs3754418 chr1:227348473 T/C cg10327440 chr1:227177885 CDC42BPA -0.47 -9.36 -0.35 1.31e-19 Neutrophil percentage of white cells; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg22764044 chr5:178986830 RUFY1 0.4 10.29 0.38 4.36e-23 Lung cancer; BRCA cis rs8114671 0.562 rs6058137 chr20:33475074 G/A cg07148914 chr20:33460835 GGT7 0.46 9.76 0.36 4.67e-21 Height; BRCA cis rs3733346 0.553 rs2290403 chr4:942006 G/A cg23939001 chr4:940644 TMEM175 0.42 10.2 0.37 9.94e-23 Sjögren's syndrome; BRCA cis rs17270561 0.609 rs9393659 chr6:25731358 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs1577917 0.876 rs11752223 chr6:86573394 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.43 -0.41 1.14e-27 Response to antipsychotic treatment; BRCA cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg01579765 chr21:45077557 HSF2BP -0.39 -10.5 -0.38 6.5e-24 Mean corpuscular volume; BRCA cis rs2303759 0.626 rs12982246 chr19:49801169 A/G cg24324837 chr19:49891574 CCDC155 0.45 7.88 0.3 1.39e-14 Multiple sclerosis; BRCA cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg01689657 chr7:91764605 CYP51A1 0.22 8.12 0.31 2.36e-15 Breast cancer; BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg03709012 chr19:19516395 GATAD2A 0.8 18.61 0.59 4.56e-62 Tonsillectomy; BRCA cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg21856205 chr7:94953877 PON1 -0.38 -8.24 -0.31 1e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs312273 0.806 rs2289522 chr12:41330531 T/C cg17827154 chr12:41323612 CNTN1 -0.43 -11.11 -0.4 2.47e-26 Bipolar disorder; BRCA cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg06627628 chr2:24431161 ITSN2 -0.51 -8.28 -0.31 7.01e-16 Lymphocyte counts; BRCA cis rs4766646 0.619 rs7304559 chr12:110289501 T/G cg01252219 chr12:110302105 GLTP 0.36 7.88 0.3 1.46e-14 Metabolite levels (MHPG); BRCA cis rs10463316 0.894 rs10062856 chr5:150768196 C/G cg03212797 chr5:150827313 SLC36A1 -0.43 -8.33 -0.31 4.96e-16 Metabolite levels (Pyroglutamine); BRCA cis rs35306767 0.903 rs12260800 chr10:927933 T/C cg26597838 chr10:835615 NA 1.01 18.07 0.58 2.9e-59 Eosinophil percentage of granulocytes; BRCA cis rs10791323 0.593 rs10791329 chr11:133716356 T/C cg15485101 chr11:133734466 NA 0.4 9.66 0.36 1.07e-20 Childhood ear infection; BRCA cis rs7408868 0.706 rs7257550 chr19:15292088 C/G cg14696996 chr19:15285081 NOTCH3 0.79 12.36 0.44 1.34e-31 Pulse pressure; BRCA trans rs11039798 0.844 rs6485820 chr11:48264711 A/G cg15704280 chr7:45808275 SEPT13 0.52 7.86 0.3 1.62e-14 Axial length; BRCA cis rs6570726 0.791 rs9373463 chr6:145894762 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 7e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs13096357 0.520 rs17080319 chr3:48732480 T/C cg00383909 chr3:49044727 WDR6 0.59 11.1 0.4 2.77e-26 Cognitive ability (multi-trait analysis); BRCA trans rs3780486 0.801 rs56687083 chr9:33132134 A/G cg20290983 chr6:43655470 MRPS18A 1.1 41.39 0.85 5.5e-183 IgG glycosylation; BRCA cis rs4665809 0.531 rs12990692 chr2:26464939 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.01 22.16 0.66 3.76e-81 Gut microbiome composition (summer); BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg05863683 chr7:1912471 MAD1L1 0.36 8.35 0.31 4.35e-16 Bipolar disorder and schizophrenia; BRCA cis rs8062405 1.000 rs62037367 chr16:28874547 C/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2832077 0.943 rs11702320 chr21:30195251 A/T cg24692254 chr21:30365293 RNF160 -0.47 -8.12 -0.31 2.39e-15 Cognitive test performance; BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg08280861 chr8:58055591 NA 0.54 8.78 0.33 1.45e-17 Developmental language disorder (linguistic errors); BRCA cis rs6089584 1.000 rs6089583 chr20:60563624 G/A cg06108461 chr20:60628389 TAF4 -0.79 -17.05 -0.56 5.51e-54 Body mass index; BRCA cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs6815814 1.000 rs11722836 chr4:38811529 T/A cg02016764 chr4:38805732 TLR1 -0.6 -9.25 -0.34 3.2e-19 Breast cancer; BRCA cis rs12618769 0.625 rs76362434 chr2:99118005 C/T cg10123293 chr2:99228465 UNC50 0.45 8.66 0.32 3.95e-17 Bipolar disorder; BRCA cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA trans rs2018683 1.000 rs160837 chr7:29012732 C/G cg19402173 chr7:128379420 CALU -0.59 -14.84 -0.51 5.09e-43 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.658 rs10815145 chr9:5013309 G/A cg02405213 chr9:5042618 JAK2 -0.46 -8.54 -0.32 9.74e-17 Pediatric autoimmune diseases; BRCA trans rs2840044 1.000 rs225243 chr17:33947212 A/G cg19694781 chr19:47549865 TMEM160 -0.45 -10.54 -0.38 4.69e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs2204008 0.715 rs11525003 chr12:38332359 G/A cg26384229 chr12:38710491 ALG10B 0.75 17.26 0.56 4.56e-55 Bladder cancer; BRCA cis rs11711311 0.911 rs9817327 chr3:113478500 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.16 0.4 1.46e-26 IgG glycosylation; BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg08280861 chr8:58055591 NA 0.53 8.46 0.32 1.87e-16 Developmental language disorder (linguistic errors); BRCA cis rs6763687 0.765 rs11923349 chr3:171771749 T/C cg16233210 chr3:171778391 FNDC3B 0.37 7.92 0.3 1.07e-14 Red cell distribution width; BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg25036284 chr2:26402008 FAM59B -0.64 -11.0 -0.4 6.63e-26 Gut microbiome composition (summer); BRCA cis rs4808199 0.948 rs2301671 chr19:19466269 C/T cg03709012 chr19:19516395 GATAD2A 0.91 17.64 0.57 4.93e-57 Nonalcoholic fatty liver disease; BRCA cis rs7766436 0.648 rs3734214 chr6:22571414 C/G cg13666174 chr6:22585274 NA -0.39 -10.0 -0.37 5.5e-22 Coronary artery disease; BRCA cis rs7312933 1.000 rs10880230 chr12:42450253 G/A cg17420585 chr12:42539391 GXYLT1 -0.49 -10.62 -0.39 2.28e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs524281 0.861 rs10896087 chr11:65924549 A/G cg16950941 chr11:66035639 RAB1B -0.37 -7.84 -0.3 1.91e-14 Electroencephalogram traits; BRCA cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.72 -0.33 2.37e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs250677 0.522 rs1432801 chr5:148390979 T/C cg12140854 chr5:148520817 ABLIM3 -0.41 -8.45 -0.32 2e-16 Breast cancer; BRCA cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg10523679 chr1:76189770 ACADM 0.7 12.72 0.45 3.51e-33 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs752010 0.806 rs943375 chr1:42092152 A/G cg06885757 chr1:42089581 HIVEP3 0.28 10.23 0.38 7.7e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg08999081 chr20:33150536 PIGU 0.46 12.85 0.45 8.96e-34 Coronary artery disease; BRCA trans rs911555 0.755 rs12435516 chr14:103954404 T/C cg17675199 chr6:35436792 RPL10A -0.3 -8.14 -0.31 2e-15 Intelligence (multi-trait analysis); BRCA cis rs7927592 0.913 rs7104345 chr11:68316772 G/A cg20283391 chr11:68216788 NA -0.47 -9.17 -0.34 6.26e-19 Total body bone mineral density; BRCA cis rs495337 1.000 rs2281216 chr20:48568503 C/T cg17835207 chr20:48524531 SPATA2 -0.64 -15.09 -0.51 3.27e-44 Psoriasis; BRCA cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.72e-18 Alzheimer's disease (late onset); BRCA cis rs7264396 0.836 rs6120995 chr20:34185726 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.56 -11.81 -0.42 3e-29 Total cholesterol levels; BRCA cis rs7772486 0.654 rs6928007 chr6:146074941 G/A cg23711669 chr6:146136114 FBXO30 -0.72 -17.11 -0.56 2.7e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs58235267 0.656 rs13410889 chr2:63087778 T/C cg17519650 chr2:63277830 OTX1 0.42 9.13 0.34 8.74e-19 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs801193 0.591 rs2707839 chr7:66193084 A/G cg12463550 chr7:65579703 CRCP 0.38 8.11 0.31 2.58e-15 Aortic root size; BRCA trans rs11098499 0.754 rs1849457 chr4:120254355 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.36 0.38 2.3e-23 Corneal astigmatism; BRCA cis rs35740288 0.539 rs4843101 chr15:86339661 G/T cg20737812 chr15:86336631 KLHL25 -0.39 -8.5 -0.32 1.31e-16 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs12497850 0.931 rs9867373 chr3:48960938 A/T cg07636037 chr3:49044803 WDR6 0.97 29.41 0.76 6.97e-121 Parkinson's disease; BRCA cis rs60843830 1.000 rs36216559 chr2:262335 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.55 0.5 1.22e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10504229 1.000 rs59549824 chr8:58186205 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.69 -0.36 8.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.620 rs7699512 chr4:10125808 C/T cg11266682 chr4:10021025 SLC2A9 -0.37 -9.61 -0.36 1.58e-20 Bone mineral density; BRCA cis rs7246657 0.507 rs8107654 chr19:37453534 C/T cg18154014 chr19:37997991 ZNF793 0.51 7.89 0.3 1.29e-14 Coronary artery calcification; BRCA cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg04450456 chr4:17643702 FAM184B 0.37 11.13 0.4 2.09e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11190604 1.000 rs2489048 chr10:102348497 G/T cg07080220 chr10:102295463 HIF1AN 0.6 13.13 0.46 4.71e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7809950 1.000 rs10267907 chr7:107184466 C/T cg23024343 chr7:107201750 COG5 -0.41 -9.24 -0.34 3.62e-19 Coronary artery disease; BRCA cis rs7246967 0.673 rs3853650 chr19:22880490 A/G cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs7246657 0.722 rs2909105 chr19:38167906 A/G cg23950597 chr19:37808831 NA 0.5 8.57 0.32 7.91e-17 Coronary artery calcification; BRCA cis rs10504073 0.669 rs55948643 chr8:50026403 C/G cg00325661 chr8:49890786 NA 0.38 11.22 0.41 8.47e-27 Blood metabolite ratios; BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.06 0.3 3.74e-15 Tonsillectomy; BRCA cis rs28374715 0.662 rs72737786 chr15:41500361 G/T cg18705301 chr15:41695430 NDUFAF1 -0.83 -17.39 -0.57 9.52e-56 Ulcerative colitis; BRCA cis rs875971 0.545 rs2173571 chr7:65770379 G/A cg11764359 chr7:65958608 NA 0.65 11.14 0.4 1.9e-26 Aortic root size; BRCA cis rs6495122 0.501 rs6495144 chr15:75343438 T/C cg13906792 chr15:75199810 C15orf17 0.35 8.1 0.31 2.74e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; BRCA trans rs7824557 0.872 rs6601577 chr8:11102682 C/G cg15556689 chr8:8085844 FLJ10661 0.29 7.9 0.3 1.23e-14 Retinal vascular caliber; BRCA cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.47 -9.75 -0.36 5.06e-21 Tonsillectomy; BRCA cis rs10751667 0.666 rs6597967 chr11:950583 G/T cg06064525 chr11:970664 AP2A2 -0.48 -16.27 -0.54 4.72e-50 Alzheimer's disease (late onset); BRCA cis rs1475911 0.708 rs56185023 chr21:43521538 T/C cg19766460 chr21:43528205 UMODL1;C21orf128 0.85 18.41 0.59 5.11e-61 IgG glycosylation; BRCA cis rs220324 0.688 rs9975464 chr21:43560055 T/C cg09727148 chr21:43560719 UMODL1 0.5 8.88 0.33 6.65e-18 Idiopathic osteonecrosis of the femoral head; BRCA cis rs6580649 0.783 rs1635526 chr12:48396785 C/T cg05342945 chr12:48394962 COL2A1 -0.49 -9.73 -0.36 5.98e-21 Lung cancer; BRCA cis rs9649465 0.967 rs10269196 chr7:123321073 G/T cg04330084 chr7:123175371 IQUB -0.32 -8.77 -0.33 1.55e-17 Migraine; BRCA cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg08493051 chr2:3487164 NA -0.43 -9.22 -0.34 4.1e-19 Neurofibrillary tangles; BRCA cis rs6762477 0.748 rs3755831 chr3:50228767 G/T cg24110177 chr3:50126178 RBM5 0.39 10.35 0.38 2.63e-23 Menarche (age at onset); BRCA cis rs4363385 0.791 rs512198 chr1:153006245 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.29 -0.31 6.75e-16 Inflammatory skin disease; BRCA cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs7172677 0.737 rs7178625 chr15:75441017 A/G cg14664628 chr15:75095509 CSK -0.39 -8.05 -0.3 4.04e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2354432 0.607 rs12402309 chr1:146721983 T/A cg25205988 chr1:146714368 CHD1L -0.95 -13.57 -0.47 4.88e-37 Mitochondrial DNA levels; BRCA cis rs7851660 0.967 rs3021526 chr9:100617021 C/T cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.78e-17 Strep throat; BRCA cis rs7647973 1.000 rs73088137 chr3:49448423 G/A cg07636037 chr3:49044803 WDR6 -0.77 -15.44 -0.52 5.92e-46 Menarche (age at onset); BRCA cis rs3096299 0.658 rs3934737 chr16:89560209 G/A cg08822215 chr16:89438651 ANKRD11 -0.38 -7.99 -0.3 6.42e-15 Multiple myeloma (IgH translocation); BRCA cis rs17209837 0.607 rs17149644 chr7:87086218 T/C cg00919237 chr7:87102261 ABCB4 -0.53 -10.24 -0.38 6.86e-23 Gallbladder cancer; BRCA cis rs870825 0.616 rs57271221 chr4:185627198 C/T cg20176042 chr4:185552304 CASP3 -0.53 -8.12 -0.31 2.38e-15 Blood protein levels; BRCA cis rs7903847 0.620 rs61863815 chr10:99124389 A/G cg08345082 chr10:99160200 RRP12 -0.28 -8.05 -0.3 4.06e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs7408868 1.000 rs2074617 chr19:15276055 C/G cg14696996 chr19:15285081 NOTCH3 0.98 14.37 0.49 8.85e-41 Pulse pressure; BRCA cis rs10465746 0.780 rs7550413 chr1:84423891 T/A cg10977910 chr1:84465055 TTLL7 0.58 12.03 0.43 3.39e-30 Obesity-related traits; BRCA cis rs921968 0.541 rs3770216 chr2:219443717 A/G cg02176678 chr2:219576539 TTLL4 -0.51 -13.19 -0.46 2.56e-35 Mean corpuscular hemoglobin concentration; BRCA trans rs6582630 0.502 rs11520278 chr12:38359642 T/A cg06521331 chr12:34319734 NA -0.52 -9.3 -0.35 2.25e-19 Drug-induced liver injury (flucloxacillin); BRCA trans rs7647973 0.626 rs11709734 chr3:49745235 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -8.49 -0.32 1.4e-16 Menarche (age at onset); BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg22920501 chr2:26401640 FAM59B 0.76 10.54 0.38 4.83e-24 Gut microbiome composition (summer); BRCA cis rs875971 0.862 rs6955837 chr7:66043142 C/T cg11764359 chr7:65958608 NA -0.75 -16.67 -0.55 4.5e-52 Aortic root size; BRCA cis rs888194 0.686 rs11067376 chr12:110027795 A/G cg05360138 chr12:110035743 NA 0.39 8.52 0.32 1.18e-16 Neuroticism; BRCA cis rs11229555 0.609 rs4598685 chr11:58216864 A/G cg15696309 chr11:58395628 NA -0.45 -9.6 -0.35 1.79e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs11229555 0.645 rs12794534 chr11:58179568 C/A cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6430585 0.527 rs62168830 chr2:136443900 A/T cg07169764 chr2:136633963 MCM6 1.0 19.4 0.61 2.78e-66 Corneal structure; BRCA trans rs7647973 0.587 rs10452032 chr3:49680973 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.81 -0.3 2.3e-14 Menarche (age at onset); BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg04944784 chr2:26401820 FAM59B -0.84 -13.2 -0.46 2.48e-35 Gut microbiome composition (summer); BRCA cis rs9837602 0.507 rs1718244 chr3:99512608 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.11 0.31 2.64e-15 Breast cancer; BRCA cis rs6570726 0.905 rs430248 chr6:145874104 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.95 0.51 1.56e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12826209 chr6:26865740 GUSBL1 0.58 10.3 0.38 3.88e-23 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.13 0.49 1.22e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17818399 0.712 rs13008088 chr2:46781580 C/G cg02822958 chr2:46747628 ATP6V1E2 0.59 11.79 0.42 3.65e-29 Height; BRCA cis rs546131 0.928 rs552868 chr11:34830694 G/A cg06937548 chr11:34938143 PDHX;APIP 0.46 8.75 0.33 1.96e-17 Lung disease severity in cystic fibrosis; BRCA cis rs2712381 0.797 rs62270806 chr3:128376269 C/T cg16766828 chr3:128327626 NA -0.43 -9.6 -0.36 1.71e-20 Monocyte count; BRCA cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg04450456 chr4:17643702 FAM184B 0.38 11.44 0.41 1.06e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs312273 0.693 rs7314287 chr12:41334075 G/A cg17827154 chr12:41323612 CNTN1 -0.39 -10.08 -0.37 2.72e-22 Bipolar disorder; BRCA cis rs7737355 1.000 rs27421 chr5:130743771 C/T cg06307176 chr5:131281290 NA -0.45 -8.79 -0.33 1.38e-17 Life satisfaction; BRCA cis rs12701220 0.553 rs7782024 chr7:1157502 G/T cg26769984 chr7:1090371 C7orf50 0.47 8.99 0.34 2.67e-18 Bronchopulmonary dysplasia; BRCA trans rs9858542 1.000 rs9812791 chr3:49682311 G/A cg21659725 chr3:3221576 CRBN -0.49 -10.32 -0.38 3.47e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4481887 0.893 rs4529743 chr1:248473683 G/C cg00666640 chr1:248458726 OR2T12 0.3 8.39 0.32 3.12e-16 Common traits (Other); BRCA cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg17143192 chr8:8559678 CLDN23 0.57 11.08 0.4 3.24e-26 Obesity-related traits; BRCA cis rs11229555 0.645 rs34794607 chr11:58188401 A/T cg15696309 chr11:58395628 NA -0.52 -10.83 -0.39 3.19e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7914558 0.966 rs56946876 chr10:104653545 T/C cg04362960 chr10:104952993 NT5C2 0.42 10.14 0.37 1.67e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs701145 0.938 rs701144 chr3:154059576 C/T cg17054900 chr3:154042577 DHX36 0.67 11.69 0.42 9.13e-29 Coronary artery disease; BRCA trans rs7615952 0.512 rs4646765 chr3:125820707 G/A cg07211511 chr3:129823064 LOC729375 -0.62 -10.85 -0.39 2.79e-25 Blood pressure (smoking interaction); BRCA trans rs3733585 0.673 rs7376948 chr4:9954708 G/A cg26043149 chr18:55253948 FECH -0.37 -8.17 -0.31 1.71e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.51 8.31 0.31 5.63e-16 Renal function-related traits (BUN); BRCA cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24308560 chr3:49941425 MST1R -0.4 -8.6 -0.32 6.12e-17 Intelligence (multi-trait analysis); BRCA trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg20290983 chr6:43655470 MRPS18A -1.1 -41.38 -0.85 5.93e-183 IgG glycosylation; BRCA cis rs7772486 0.806 rs2265477 chr6:146212338 T/C cg23711669 chr6:146136114 FBXO30 0.66 15.36 0.52 1.47e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs4478858 0.735 rs10914344 chr1:31769025 T/C cg00250761 chr1:31883323 NA -0.31 -8.01 -0.3 5.55e-15 Alcohol dependence; BRCA cis rs1580019 0.563 rs764483 chr7:32578150 A/T cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.23 0.31 1.03e-15 Cognitive ability; BRCA trans rs17685 0.753 rs869804 chr7:75688954 A/G cg19862616 chr7:65841803 NCRNA00174 0.84 27.55 0.74 9.65e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs13217239 0.646 rs7451149 chr6:27057518 A/G cg12292205 chr6:26970375 C6orf41 -0.56 -12.3 -0.44 2.35e-31 Schizophrenia; BRCA cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.684 rs3910756 chr15:76945369 C/T cg23625390 chr15:77176239 SCAPER -0.53 -12.01 -0.43 4.07e-30 Blood metabolite levels; BRCA cis rs2637266 0.967 rs12246605 chr10:78352994 G/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA trans rs208520 1.000 rs12190187 chr6:66973207 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.38 0.49 8.24e-41 Exhaled nitric oxide output; BRCA cis rs10504229 1.000 rs949848 chr8:58169125 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs6598955 0.617 rs11247883 chr1:26576247 T/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs7246657 0.765 rs7247259 chr19:37851090 T/C cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg11301795 chr4:187892539 NA -0.26 -8.71 -0.33 2.57e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7605378 0.528 rs281767 chr2:200823281 C/A cg23649088 chr2:200775458 C2orf69 0.7 15.4 0.52 9.44e-46 Osteoporosis; BRCA trans rs1493916 0.748 rs34501189 chr18:31314196 A/G cg15819921 chr19:927150 ARID3A -0.42 -8.03 -0.3 4.63e-15 Life satisfaction; BRCA cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.77 16.29 0.54 3.91e-50 Smoking behavior; BRCA cis rs2652822 0.525 rs2899691 chr15:63519088 T/A cg02713581 chr15:63449717 RPS27L 0.4 7.83 0.3 2.02e-14 Metabolic traits; BRCA cis rs9393777 0.513 rs3999471 chr6:26650306 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs6546550 0.935 rs2305523 chr2:70039677 G/T cg02498382 chr2:70120550 SNRNP27 0.48 10.22 0.37 8.06e-23 Prevalent atrial fibrillation; BRCA cis rs7586879 0.828 rs13428789 chr2:25087643 C/T cg04586622 chr2:25135609 ADCY3 0.37 9.05 0.34 1.64e-18 Body mass index; BRCA cis rs801193 1.000 rs2659915 chr7:66153101 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.27 0.31 7.73e-16 Aortic root size; BRCA cis rs708547 0.676 rs11133470 chr4:57864926 G/T cg25525207 chr4:57843836 C4orf14;POLR2B -0.43 -8.82 -0.33 1.09e-17 Response to bleomycin (chromatid breaks); BRCA cis rs7666738 0.830 rs1876192 chr4:98727555 T/C cg05340658 chr4:99064831 C4orf37 0.63 15.15 0.51 1.51e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.901 rs1027813 chr6:79552118 G/T cg18132916 chr6:79620363 NA 0.45 10.59 0.39 2.96e-24 Intelligence (multi-trait analysis); BRCA cis rs9911578 0.967 rs3826353 chr17:57075299 C/T cg05425664 chr17:57184151 TRIM37 -0.44 -11.17 -0.4 1.37e-26 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs28818180 chr4:98953625 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9291683 0.552 rs11736410 chr4:10017241 G/A cg02734326 chr4:10020555 SLC2A9 0.4 8.86 0.33 8.2e-18 Bone mineral density; BRCA cis rs1577917 0.883 rs2660575 chr6:86684995 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.34 -9.03 -0.34 2.06e-18 Response to antipsychotic treatment; BRCA cis rs6430585 0.528 rs12476127 chr2:136763242 A/G cg07169764 chr2:136633963 MCM6 1.27 26.4 0.72 2.13e-104 Corneal structure; BRCA trans rs877282 0.735 rs111609055 chr10:826539 A/G cg22713356 chr15:30763199 NA 0.87 14.23 0.49 4e-40 Uric acid levels; BRCA cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.77 -0.5 1.05e-42 Total cholesterol levels; BRCA cis rs1865760 0.865 rs2164485 chr6:25952106 G/A cg16482183 chr6:26056742 HIST1H1C 0.5 10.41 0.38 1.57e-23 Height; BRCA cis rs10791323 0.604 rs2723607 chr11:133711018 C/G cg15485101 chr11:133734466 NA 0.4 9.46 0.35 5.7e-20 Childhood ear infection; BRCA cis rs7586879 0.828 rs1077641 chr2:25123665 G/A cg04586622 chr2:25135609 ADCY3 0.4 9.55 0.35 2.77e-20 Body mass index; BRCA cis rs752010 1.000 rs6664724 chr1:42093821 G/A cg06885757 chr1:42089581 HIVEP3 0.27 9.65 0.36 1.17e-20 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2658782 0.789 rs3020057 chr11:93118515 C/T cg15737290 chr11:93063684 CCDC67 0.47 9.6 0.35 1.8e-20 Pulmonary function decline; BRCA cis rs2439831 0.850 rs28718261 chr15:44043793 C/G cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.24 0.44 4.41e-31 Lung cancer in ever smokers; BRCA cis rs2204008 0.806 rs35534445 chr12:38279093 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.27 0.38 5.13e-23 Bladder cancer; BRCA cis rs4727027 0.870 rs62507485 chr7:148764182 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.05 0.37 3.52e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg01206211 chr2:36825736 FEZ2 -0.44 -10.58 -0.39 3.14e-24 Height; BRCA cis rs6558530 0.897 rs7838456 chr8:1707591 T/G cg19131313 chr8:1704013 NA -0.37 -8.02 -0.3 5.08e-15 Systolic blood pressure; BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg11814155 chr7:99998594 ZCWPW1 0.59 10.07 0.37 3.03e-22 Platelet count; BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg13880726 chr7:1868755 MAD1L1 0.38 7.84 0.3 1.88e-14 Bipolar disorder and schizophrenia; BRCA cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg07138768 chr7:917805 C7orf20 0.31 8.99 0.34 2.73e-18 Perceived unattractiveness to mosquitoes; BRCA cis rs796364 0.806 rs1106400 chr2:201004089 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.54 -8.52 -0.32 1.1e-16 Schizophrenia; BRCA trans rs7824557 0.767 rs11775635 chr8:11164865 G/A cg08975724 chr8:8085496 FLJ10661 0.43 8.0 0.3 5.84e-15 Retinal vascular caliber; BRCA cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg04455712 chr21:45112962 RRP1B 0.42 11.07 0.4 3.5e-26 Mean corpuscular volume; BRCA cis rs17253792 0.822 rs75509578 chr14:56133493 G/A cg01858014 chr14:56050164 KTN1 -0.75 -10.09 -0.37 2.66e-22 Putamen volume; BRCA cis rs12477438 0.501 rs12995473 chr2:99764884 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.32 0.66 4.72e-82 Chronic sinus infection; BRCA cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.01e-15 Alzheimer's disease (late onset); BRCA cis rs62229266 0.771 rs11701590 chr21:37384730 A/C cg12218747 chr21:37451666 NA -0.34 -8.11 -0.31 2.57e-15 Mitral valve prolapse; BRCA cis rs2953145 0.568 rs1133352 chr2:241522252 A/G cg07929629 chr2:241523174 NA -0.53 -11.8 -0.42 3.21e-29 Bipolar disorder; BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg13628971 chr7:2884303 GNA12 0.47 9.21 0.34 4.6e-19 Height; BRCA cis rs7246967 0.673 rs57027767 chr19:22876535 A/G cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs7927771 0.524 rs10742824 chr11:47864842 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.49 0.35 4.65e-20 Subjective well-being; BRCA cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.99e-35 Bone mineral density; BRCA cis rs950776 0.647 rs495956 chr15:78869930 C/T cg06917634 chr15:78832804 PSMA4 -0.55 -11.98 -0.43 5.61e-30 Sudden cardiac arrest; BRCA cis rs875971 0.617 rs810400 chr7:66022889 G/C cg18876405 chr7:65276391 NA -0.62 -15.48 -0.52 3.8e-46 Aortic root size; BRCA cis rs2281845 0.507 rs942703 chr1:201092979 A/G cg06714761 chr1:201096289 NA -0.54 -13.98 -0.48 5.85e-39 Permanent tooth development; BRCA cis rs6121246 0.954 rs6121245 chr20:30432060 G/A cg13852791 chr20:30311386 BCL2L1 0.76 14.16 0.49 8.35e-40 Mean corpuscular hemoglobin; BRCA cis rs60871478 0.636 rs12532761 chr7:905229 C/T cg05535760 chr7:792225 HEATR2 -0.73 -11.61 -0.42 2.11e-28 Cerebrospinal P-tau181p levels; BRCA cis rs600806 0.778 rs518697 chr1:110014778 G/A cg20591472 chr1:110008990 SYPL2 0.31 7.9 0.3 1.25e-14 Intelligence (multi-trait analysis); BRCA trans rs1493916 0.870 rs8097667 chr18:31387003 C/T cg27147174 chr7:100797783 AP1S1 -0.54 -10.72 -0.39 8.93e-25 Life satisfaction; BRCA cis rs72772090 0.908 rs6864233 chr5:96044681 A/G cg17330273 chr5:96107758 CAST;ERAP1 0.45 10.63 0.39 2.09e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.565 rs2836939 chr21:40578546 C/T cg17971929 chr21:40555470 PSMG1 0.6 9.69 0.36 7.98e-21 Cognitive function; BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg21782813 chr7:2030301 MAD1L1 0.41 10.83 0.39 3.14e-25 Bipolar disorder and schizophrenia; BRCA cis rs875971 0.545 rs316305 chr7:65617971 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.97 -0.37 7.59e-22 Aortic root size; BRCA cis rs2425143 1.000 rs6060643 chr20:34449851 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.54 -0.32 9.92e-17 Blood protein levels; BRCA cis rs7666738 0.830 rs10012003 chr4:99064881 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.79 0.39 4.76e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs611744 0.647 rs676654 chr8:109242303 A/G cg21045802 chr8:109455806 TTC35 0.39 8.63 0.32 4.97e-17 Dupuytren's disease; BRCA cis rs875971 0.638 rs801216 chr7:66011667 T/C cg11764359 chr7:65958608 NA -0.68 -15.19 -0.52 9.94e-45 Aortic root size; BRCA cis rs2839186 0.814 rs13052376 chr21:47707403 G/C cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs8114671 0.839 rs6142290 chr20:33654672 A/C cg07148914 chr20:33460835 GGT7 -0.43 -9.17 -0.34 6.56e-19 Height; BRCA cis rs7264396 0.635 rs3827030 chr20:34474947 C/T cg04508476 chr20:34239394 CPNE1;RBM12 0.68 13.93 0.48 1.01e-38 Total cholesterol levels; BRCA cis rs1448094 0.512 rs61930864 chr12:86246740 G/A cg19622623 chr12:86230825 RASSF9 -0.34 -9.6 -0.36 1.79e-20 Major depressive disorder; BRCA cis rs651907 0.557 rs17347644 chr3:101547733 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 13.86 0.48 2.19e-38 Colorectal cancer; BRCA cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg16414030 chr3:133502952 NA -0.49 -11.29 -0.41 4.33e-27 Iron status biomarkers; BRCA cis rs9290065 0.519 rs6770180 chr3:160703786 C/T cg03342759 chr3:160939853 NMD3 -0.49 -9.95 -0.37 9.17e-22 Kawasaki disease; BRCA cis rs796364 0.806 rs12619136 chr2:200910347 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs1595825 0.945 rs2139050 chr2:198852636 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.18 -0.31 1.58e-15 Ulcerative colitis; BRCA cis rs60843830 0.596 rs17041320 chr2:112051 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.44 7.87 0.3 1.52e-14 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9311474 0.508 rs11714565 chr3:52606292 C/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.82 -0.3 2.22e-14 Electroencephalogram traits; BRCA cis rs7903847 0.642 rs12258560 chr10:99137048 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.62 -0.32 5.45e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs870825 0.616 rs41278579 chr4:185622402 A/G cg20176042 chr4:185552304 CASP3 -0.53 -8.12 -0.31 2.38e-15 Blood protein levels; BRCA cis rs965469 0.724 rs2007022 chr20:3237674 C/A cg25506879 chr20:3388711 C20orf194 -0.43 -8.68 -0.32 3.38e-17 IFN-related cytopenia; BRCA cis rs9443645 0.810 rs9448607 chr6:79715620 G/A cg11833968 chr6:79620685 NA -0.39 -8.71 -0.33 2.58e-17 Intelligence (multi-trait analysis); BRCA cis rs7903847 0.620 rs954149 chr10:99122936 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.34 -0.31 4.62e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs12541635 0.966 rs62525736 chr8:107000638 G/C cg10147462 chr8:107024639 NA 0.38 9.89 0.36 1.54e-21 Age of smoking initiation; BRCA cis rs523522 0.962 rs9788155 chr12:120938408 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.43e-36 High light scatter reticulocyte count; BRCA cis rs2836974 0.568 rs2836969 chr21:40648265 G/A cg22974920 chr21:40686053 BRWD1 -0.38 -8.7 -0.33 2.86e-17 Cognitive function; BRCA cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg21573476 chr21:45109991 RRP1B -0.44 -10.68 -0.39 1.26e-24 Mean corpuscular volume; BRCA cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg08392591 chr16:89556376 ANKRD11 0.46 11.12 0.4 2.19e-26 Multiple myeloma (IgH translocation); BRCA cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.5 7.94 0.3 9.05e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs514406 0.679 rs960570 chr1:53237763 A/G cg16325326 chr1:53192061 ZYG11B -0.56 -11.5 -0.41 5.71e-28 Monocyte count; BRCA cis rs9399135 0.660 rs9376072 chr6:135280519 G/C cg24558204 chr6:135376177 HBS1L 0.49 13.6 0.47 3.69e-37 Red blood cell count; BRCA cis rs4478858 0.647 rs11577679 chr1:31726185 T/C cg00250761 chr1:31883323 NA -0.32 -8.29 -0.31 6.93e-16 Alcohol dependence; BRCA cis rs4363385 0.747 rs1055935 chr1:152975941 C/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.07 -0.34 1.48e-18 Inflammatory skin disease; BRCA cis rs36051895 0.623 rs76960049 chr9:5064548 G/A cg02405213 chr9:5042618 JAK2 -0.52 -10.0 -0.37 5.78e-22 Pediatric autoimmune diseases; BRCA cis rs6582630 0.502 rs11520278 chr12:38359642 T/A cg26384229 chr12:38710491 ALG10B 0.77 17.45 0.57 4.59e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.76 12.39 0.44 9.29e-32 Mean platelet volume; BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.75 -0.45 2.45e-33 Lymphocyte counts; BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg22903471 chr2:27725779 GCKR -0.37 -8.91 -0.33 5.12e-18 Total body bone mineral density; BRCA cis rs10489202 0.608 rs35059151 chr1:168079393 C/A cg24449463 chr1:168025552 DCAF6 -0.46 -15.12 -0.51 2.29e-44 Schizophrenia; BRCA cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg21573476 chr21:45109991 RRP1B -0.41 -11.19 -0.4 1.11e-26 Mean corpuscular volume; BRCA cis rs4077515 0.504 rs10870164 chr9:139315682 C/T cg14169450 chr9:139327907 INPP5E -0.41 -9.78 -0.36 3.91e-21 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6088580 0.634 rs6059856 chr20:33057954 G/C cg24642439 chr20:33292090 TP53INP2 0.51 11.35 0.41 2.44e-27 Glomerular filtration rate (creatinine); BRCA cis rs2033711 0.728 rs4801586 chr19:58934528 A/G cg26874164 chr19:58962979 ZNF324B 0.44 9.39 0.35 1.03e-19 Uric acid clearance; BRCA cis rs6964587 1.000 rs1859114 chr7:91682848 T/C cg17063962 chr7:91808500 NA 0.52 12.44 0.44 5.66e-32 Breast cancer; BRCA cis rs11718455 0.960 rs35869565 chr3:44002394 G/C cg08738300 chr3:44038990 NA 0.44 8.6 0.32 6.11e-17 Coronary artery disease; BRCA cis rs651907 0.535 rs11714444 chr3:101513682 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.49 0.47 1.16e-36 Colorectal cancer; BRCA cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.31 -0.35 1.95e-19 Tonsillectomy; BRCA cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg24209194 chr3:40518798 ZNF619 -0.4 -8.3 -0.31 6.37e-16 Renal cell carcinoma; BRCA cis rs11190604 0.943 rs11190581 chr10:102243387 T/G cg07080220 chr10:102295463 HIF1AN 0.5 11.39 0.41 1.76e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10504229 0.610 rs6987118 chr8:58147851 G/T cg24829409 chr8:58192753 C8orf71 -0.44 -8.82 -0.33 1.05e-17 Developmental language disorder (linguistic errors); BRCA cis rs4689388 0.853 rs1079216 chr4:6282473 T/C cg00701064 chr4:6280414 WFS1 0.67 17.2 0.56 8.78e-55 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6977660 0.714 rs10251774 chr7:19790489 T/C cg07541023 chr7:19748670 TWISTNB 0.64 10.52 0.38 5.59e-24 Thyroid stimulating hormone; BRCA cis rs2688608 0.592 rs7909802 chr10:75484186 G/C cg23231163 chr10:75533350 FUT11 -0.34 -8.83 -0.33 9.85e-18 Inflammatory bowel disease; BRCA cis rs694739 0.628 rs617051 chr11:64133638 C/A cg26898376 chr11:64110657 CCDC88B 0.36 7.84 0.3 1.95e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg23055938 chr1:160991191 F11R -0.55 -10.77 -0.39 5.5e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs875971 0.545 rs316316 chr7:65614257 C/T cg11764359 chr7:65958608 NA -0.66 -12.07 -0.43 2.28e-30 Aortic root size; BRCA cis rs17376456 0.877 rs12153506 chr5:93360953 T/G cg21475434 chr5:93447410 FAM172A 0.67 8.97 0.33 3.29e-18 Diabetic retinopathy; BRCA cis rs7267979 1.000 rs2257432 chr20:25271086 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs708547 0.581 rs6554400 chr4:57805306 A/C cg16868167 chr4:57843880 C4orf14;POLR2B -0.33 -8.32 -0.31 5.22e-16 Response to bleomycin (chromatid breaks); BRCA cis rs2404602 0.710 rs2469541 chr15:76562118 C/T cg22467129 chr15:76604101 ETFA 0.55 12.74 0.45 2.77e-33 Blood metabolite levels; BRCA cis rs3125734 0.660 rs10733769 chr10:63974255 G/T cg09941381 chr10:64027924 RTKN2 -0.29 -8.66 -0.32 3.7e-17 Rheumatoid arthritis; BRCA cis rs2066819 1.000 rs77447765 chr12:56690662 G/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs17376456 0.877 rs9314101 chr5:93461593 A/T cg25358565 chr5:93447407 FAM172A 1.2 19.89 0.62 7.04e-69 Diabetic retinopathy; BRCA trans rs6479891 1.000 rs10733790 chr10:65100334 G/C cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg11822812 chr5:140052017 DND1 -0.3 -8.28 -0.31 7.41e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs2880765 0.835 rs2170736 chr15:86043398 A/G cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.36e-17 Coronary artery disease; BRCA cis rs1564271 0.506 rs1148163 chr10:26929671 G/C cg13837822 chr10:26931731 LOC731789 0.38 8.51 0.32 1.28e-16 Overall survival in serous epithelial ovarian cancer treated with paclitaxel and cisplatin; BRCA cis rs2617583 0.679 rs2652511 chr5:1446389 A/G cg07151155 chr5:1473589 LPCAT1 -0.37 -8.07 -0.3 3.41e-15 Breast cancer; BRCA trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg03929089 chr4:120376271 NA -0.77 -17.75 -0.57 1.39e-57 Coronary artery disease; BRCA cis rs11229555 0.645 rs11560908 chr11:58434545 A/C cg15696309 chr11:58395628 NA 0.5 9.76 0.36 4.72e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7178424 0.711 rs4283171 chr15:62172384 G/T cg00456672 chr15:62358751 C2CD4A -0.36 -8.67 -0.32 3.69e-17 Height; BRCA cis rs274567 0.501 rs272855 chr5:131687175 C/T cg24060327 chr5:131705240 SLC22A5 -0.59 -10.81 -0.39 4.01e-25 Blood metabolite levels; BRCA cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg18404041 chr3:52824283 ITIH1 -0.37 -11.31 -0.41 3.51e-27 Electroencephalogram traits; BRCA cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.48 0.35 4.95e-20 Lung cancer in ever smokers; BRCA cis rs7267979 0.834 rs6115100 chr20:25225938 C/A cg08601574 chr20:25228251 PYGB 0.39 9.45 0.35 6.06e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7824557 0.547 rs2409745 chr8:11076635 G/T cg21775007 chr8:11205619 TDH 0.45 8.79 0.33 1.35e-17 Retinal vascular caliber; BRCA trans rs2018683 0.624 rs2286219 chr7:28998663 G/A cg19402173 chr7:128379420 CALU -0.49 -11.82 -0.42 2.84e-29 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs2204008 0.754 rs11181244 chr12:38302454 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Bladder cancer; BRCA cis rs10504229 0.683 rs16921808 chr8:58106049 C/T cg08219700 chr8:58056026 NA 0.48 8.48 0.32 1.56e-16 Developmental language disorder (linguistic errors); BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -18.99 -0.6 4.29e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs861020 0.771 rs654470 chr1:210014093 A/T cg09163369 chr1:210001066 C1orf107 0.64 12.36 0.44 1.33e-31 Orofacial clefts; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg05457628 chr5:178986728 RUFY1 0.5 11.84 0.42 2.19e-29 Lung cancer; BRCA cis rs9287719 0.967 rs9287720 chr2:10752664 C/T cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs6790105 1 rs6790105 chr3:49393409 C/T cg07636037 chr3:49044803 WDR6 0.76 16.53 0.55 2.38e-51 Childhood ear infection; BRCA cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.19 0.4 1.17e-26 Bipolar disorder; BRCA cis rs7666738 1.000 rs13124102 chr4:98990696 G/A cg17366294 chr4:99064904 C4orf37 0.52 11.56 0.42 3.32e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.81 -0.58 6.55e-58 Chronic sinus infection; BRCA trans rs3942852 0.806 rs4752893 chr11:48118604 C/T cg15704280 chr7:45808275 SEPT13 -0.47 -9.12 -0.34 9.76e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs12497850 0.931 rs9840050 chr3:49133310 A/G cg06212747 chr3:49208901 KLHDC8B 0.48 9.85 0.36 2.05e-21 Parkinson's disease; BRCA cis rs7568458 0.777 rs12473819 chr2:85773061 A/G cg02493740 chr2:85810744 VAMP5 -0.39 -8.18 -0.31 1.58e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs6088580 0.609 rs6059844 chr20:33036482 A/G cg08999081 chr20:33150536 PIGU 0.43 12.36 0.44 1.3e-31 Glomerular filtration rate (creatinine); BRCA cis rs9503598 0.636 rs6596978 chr6:3468878 C/T cg00476032 chr6:3446245 SLC22A23 0.37 9.09 0.34 1.26e-18 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg25036284 chr2:26402008 FAM59B -0.64 -10.61 -0.39 2.57e-24 Gut microbiome composition (summer); BRCA cis rs6690583 0.697 rs10873684 chr1:85522196 T/C cg11262906 chr1:85462892 MCOLN2 -0.49 -9.33 -0.35 1.78e-19 Serum sulfate level; BRCA cis rs12586317 0.511 rs113770696 chr14:35444383 C/T cg16230307 chr14:35515116 FAM177A1 0.74 15.49 0.52 3.31e-46 Psoriasis; BRCA cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs9811920 0.555 rs68092024 chr3:99691522 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.57 -13.21 -0.46 2.15e-35 Axial length; BRCA trans rs57221529 0.709 rs72706612 chr5:561198 C/T cg11887960 chr12:57824829 NA 0.5 8.33 0.31 5e-16 Lung disease severity in cystic fibrosis; BRCA cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs977987 0.806 rs2285225 chr16:75429252 T/C cg03315344 chr16:75512273 CHST6 0.53 12.42 0.44 7.36e-32 Dupuytren's disease; BRCA cis rs910316 0.935 rs11159119 chr14:75636967 C/T cg08847533 chr14:75593920 NEK9 -0.95 -24.92 -0.7 2.86e-96 Height; BRCA cis rs1008375 0.966 rs7658240 chr4:17588950 A/G cg04450456 chr4:17643702 FAM184B -0.38 -10.5 -0.38 6.72e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9462846 1.000 rs2092555 chr6:42863842 C/G cg02353165 chr6:42928485 GNMT 0.42 7.83 0.3 2.09e-14 Blood protein levels; BRCA cis rs3774749 0.565 rs2624839 chr3:50202231 T/C cg14019146 chr3:50243930 SLC38A3 -0.43 -10.57 -0.39 3.44e-24 Intelligence (multi-trait analysis); BRCA cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg22676075 chr6:135203613 NA 0.44 8.74 0.33 2.02e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs6842047 1.000 rs1511800 chr4:187135556 C/T cg09526685 chr4:187126073 CYP4V2 0.7 9.47 0.35 5.21e-20 Blood protein levels; BRCA cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg12311346 chr5:56204834 C5orf35 -0.62 -13.08 -0.46 7.94e-35 Initial pursuit acceleration; BRCA cis rs1005277 0.683 rs7923868 chr10:37989766 T/C cg00409905 chr10:38381863 ZNF37A -0.44 -9.24 -0.34 3.72e-19 Extrinsic epigenetic age acceleration; BRCA trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg15704280 chr7:45808275 SEPT13 -0.7 -14.47 -0.5 3.13e-41 Coronary artery disease; BRCA cis rs11690935 0.885 rs7602037 chr2:172817794 G/A cg13550731 chr2:172543902 DYNC1I2 -0.81 -24.64 -0.7 9.32e-95 Schizophrenia; BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05535760 chr7:792225 HEATR2 0.85 14.55 0.5 1.24e-41 Cerebrospinal P-tau181p levels; BRCA trans rs1005277 0.691 rs2474558 chr10:38486141 A/C cg23533926 chr12:111358616 MYL2 0.41 8.11 0.31 2.58e-15 Extrinsic epigenetic age acceleration; BRCA cis rs7267979 0.873 rs7453 chr20:25207074 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.15 0.31 1.85e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1003719 0.715 rs2835639 chr21:38537016 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.48 -0.5 2.67e-41 Eye color traits; BRCA cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg19077165 chr18:44547161 KATNAL2 -0.51 -10.98 -0.4 8.06e-26 Personality dimensions; BRCA cis rs7737355 0.947 rs6890784 chr5:130939540 T/C cg06307176 chr5:131281290 NA 0.53 10.32 0.38 3.29e-23 Life satisfaction; BRCA trans rs35110281 0.633 rs2329593 chr21:45121987 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.83 0.33 1e-17 Mean corpuscular volume; BRCA cis rs523522 0.962 rs12371550 chr12:120987643 C/T cg27279351 chr12:120934652 DYNLL1 0.56 13.17 0.46 3.14e-35 High light scatter reticulocyte count; BRCA cis rs7208859 0.673 rs2269915 chr17:29233344 C/T cg13385521 chr17:29058706 SUZ12P 0.63 8.57 0.32 7.5e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg13010199 chr12:38710504 ALG10B 0.53 11.42 0.41 1.24e-27 Heart rate; BRCA cis rs6580649 0.831 rs1635528 chr12:48395900 C/T cg05342945 chr12:48394962 COL2A1 -0.48 -9.6 -0.36 1.76e-20 Lung cancer; BRCA cis rs875971 0.862 rs778707 chr7:65857027 G/A cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs4631830 0.695 rs11004584 chr10:51500088 G/T cg20129853 chr10:51489980 NA -0.32 -8.57 -0.32 7.96e-17 Prostate-specific antigen levels; BRCA cis rs4812048 0.602 rs59637156 chr20:57619618 T/C cg14073986 chr20:57617431 SLMO2 0.8 13.37 0.47 4.19e-36 Mean platelet volume; BRCA cis rs9486715 0.867 rs4598081 chr6:96975227 A/G cg06623918 chr6:96969491 KIAA0776 0.92 27.12 0.73 2.38e-108 Headache; BRCA cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.25 0.56 4.8e-55 Bladder cancer; BRCA cis rs9359856 0.600 rs17584763 chr6:90502088 G/A cg13799429 chr6:90582589 CASP8AP2 -0.67 -8.71 -0.33 2.58e-17 Bipolar disorder; BRCA cis rs473651 0.935 rs541013 chr2:239336492 G/A cg03560586 chr2:239334908 ASB1 -0.52 -11.65 -0.42 1.46e-28 Multiple system atrophy; BRCA cis rs12618769 0.597 rs1961651 chr2:99049674 G/C cg10123293 chr2:99228465 UNC50 0.41 8.21 0.31 1.24e-15 Bipolar disorder; BRCA cis rs912057 0.695 rs1294419 chr6:6742549 C/G cg06612196 chr6:6737390 NA 0.39 8.58 0.32 7.28e-17 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs10028773 0.556 rs4473640 chr4:120260437 G/A cg09307838 chr4:120376055 NA 0.59 12.83 0.45 1.12e-33 Educational attainment; BRCA cis rs6138458 1.000 rs6707 chr20:24944166 C/T cg26195577 chr20:24973756 C20orf3 1.02 26.77 0.73 1.94e-106 Blood protein levels; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg26314531 chr2:26401878 FAM59B 0.96 16.5 0.55 3.12e-51 Gut microbiome composition (summer); BRCA trans rs3857536 0.813 rs2093253 chr6:66937702 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs270601 0.913 rs273899 chr5:131695178 G/A cg24060327 chr5:131705240 SLC22A5 -0.63 -11.79 -0.42 3.77e-29 Acylcarnitine levels; BRCA cis rs7385804 0.796 rs2432930 chr7:100299024 A/G cg16850897 chr7:100343110 ZAN 0.35 8.0 0.3 6.03e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs9487051 0.768 rs2483913 chr6:109521042 G/A cg21918786 chr6:109611834 NA -0.34 -9.15 -0.34 7.44e-19 Reticulocyte fraction of red cells; BRCA cis rs6580649 1.000 rs7132668 chr12:48405860 C/T cg24011408 chr12:48396354 COL2A1 0.54 8.98 0.33 3.04e-18 Lung cancer; BRCA cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg20891558 chr2:74357851 NA 0.54 13.08 0.46 8.03e-35 Gestational age at birth (maternal effect); BRCA trans rs35110281 0.782 rs1454651 chr21:45012476 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.73 0.33 2.28e-17 Mean corpuscular volume; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg24101359 chr6:42928495 GNMT 0.55 12.72 0.45 3.2e-33 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs1997103 0.863 rs2140916 chr7:55403154 A/C cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA trans rs11165623 0.602 rs4619021 chr1:97025910 T/C cg10631902 chr5:14652156 NA -0.43 -12.48 -0.44 3.91e-32 Hip circumference;Waist circumference; BRCA cis rs1797081 0.967 rs780633 chr10:16863161 C/T cg23933602 chr10:16859644 RSU1 0.97 32.04 0.79 4.76e-135 Platelet distribution width; BRCA cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg06618935 chr21:46677482 NA -0.37 -8.07 -0.3 3.48e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 0.830 rs7792959 chr7:99972403 C/T cg00814883 chr7:100076585 TSC22D4 -0.47 -10.6 -0.39 2.63e-24 Platelet count; BRCA cis rs2742234 0.955 rs2503865 chr10:43659536 C/T cg15436174 chr10:43711423 RASGEF1A -0.42 -8.98 -0.33 3.12e-18 Hirschsprung disease; BRCA cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg10523679 chr1:76189770 ACADM -0.51 -9.97 -0.37 7.61e-22 Daytime sleep phenotypes; BRCA cis rs7809950 0.911 rs1015411 chr7:107135612 C/T cg23024343 chr7:107201750 COG5 -0.42 -9.7 -0.36 7.52e-21 Coronary artery disease; BRCA cis rs1976403 0.659 rs10799700 chr1:21820968 G/C cg04349561 chr1:21808255 NBPF3 -0.33 -7.84 -0.3 1.96e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6088580 0.634 rs1890002 chr20:32919219 A/G cg06115741 chr20:33292138 TP53INP2 -0.37 -8.12 -0.31 2.48e-15 Glomerular filtration rate (creatinine); BRCA cis rs7246657 0.943 rs10414904 chr19:37830088 G/A cg14683738 chr19:37701593 ZNF585B 0.45 8.03 0.3 4.71e-15 Coronary artery calcification; BRCA trans rs877282 0.945 rs10904555 chr10:787740 C/A cg22713356 chr15:30763199 NA 1.42 28.54 0.75 3.84e-116 Uric acid levels; BRCA cis rs7617773 0.780 rs35778847 chr3:48346985 G/T cg11946769 chr3:48343235 NME6 0.68 13.86 0.48 2.24e-38 Coronary artery disease; BRCA cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg12350822 chr6:88032061 C6orf162;GJB7 0.41 11.41 0.41 1.36e-27 Monocyte percentage of white cells; BRCA cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg01849466 chr14:104193079 ZFYVE21 0.42 10.74 0.39 7.59e-25 Schizophrenia; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg09060608 chr5:178986726 RUFY1 0.62 16.3 0.54 3.22e-50 Lung cancer; BRCA cis rs738322 0.870 rs2277844 chr22:38577515 G/A cg25457927 chr22:38595422 NA 0.4 15.53 0.52 2.12e-46 Cutaneous nevi; BRCA cis rs2197308 0.765 rs11182434 chr12:37923968 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5e-22 Morning vs. evening chronotype; BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -12.03 -0.43 3.51e-30 Alzheimer's disease; BRCA cis rs3733585 0.673 rs4447861 chr4:9953940 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.53e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9462846 0.959 rs9471954 chr6:42880326 C/A cg02353165 chr6:42928485 GNMT 0.52 9.42 0.35 8.22e-20 Blood protein levels; BRCA cis rs9733 0.596 rs6690725 chr1:150632322 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs853679 0.546 rs200996 chr6:27811828 G/A cg26587870 chr6:27730563 NA -0.55 -8.44 -0.32 2.2e-16 Depression; BRCA cis rs877282 0.583 rs12358255 chr10:828626 C/T cg15764593 chr10:829463 NA -0.61 -10.28 -0.38 4.79e-23 Uric acid levels; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg11814155 chr7:99998594 ZCWPW1 0.46 8.4 0.32 2.93e-16 Platelet count; BRCA cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg06766960 chr11:133703094 NA 0.6 12.62 0.45 8.93e-33 Childhood ear infection; BRCA cis rs7666738 0.830 rs10470894 chr4:99039107 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.7 0.39 1.11e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg06784218 chr1:46089804 CCDC17 0.44 10.59 0.39 2.87e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 12.59 0.45 1.21e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7618501 0.602 rs2071207 chr3:50159844 T/C cg21659725 chr3:3221576 CRBN -0.46 -11.62 -0.42 1.82e-28 Intelligence (multi-trait analysis); BRCA trans rs75804782 0.572 rs77008212 chr2:239307113 A/G cg01134436 chr17:81009848 B3GNTL1 0.74 7.89 0.3 1.29e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs7727544 0.735 rs272875 chr5:131674888 T/C cg07395648 chr5:131743802 NA -0.36 -8.86 -0.33 7.68e-18 Blood metabolite levels; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg04025307 chr7:1156635 C7orf50 0.54 13.21 0.46 2.09e-35 Longevity;Endometriosis; BRCA cis rs897984 0.762 rs897986 chr16:30980902 T/C cg00531865 chr16:30841666 NA 0.39 9.25 0.34 3.21e-19 Dementia with Lewy bodies; BRCA cis rs796364 0.756 rs2949006 chr2:200715388 T/G cg23649088 chr2:200775458 C2orf69 0.58 8.55 0.32 8.73e-17 Schizophrenia; BRCA trans rs853679 0.882 rs4713140 chr6:28097193 C/T cg01620082 chr3:125678407 NA -0.55 -8.01 -0.3 5.41e-15 Depression; BRCA cis rs17125944 0.505 rs77433996 chr14:53212263 G/A cg00686598 chr14:53173677 PSMC6 1.07 15.05 0.51 4.72e-44 Alzheimer's disease (late onset); BRCA cis rs2762353 0.718 rs1165205 chr6:25870542 A/T cg12310025 chr6:25882481 NA 0.56 13.84 0.48 2.64e-38 Blood metabolite levels; BRCA cis rs12310956 0.532 rs11608842 chr12:33951121 C/T cg06521331 chr12:34319734 NA -0.52 -10.57 -0.39 3.7e-24 Morning vs. evening chronotype; BRCA cis rs34779708 0.897 rs12764820 chr10:35386321 G/A cg03585969 chr10:35415529 CREM 0.56 11.54 0.42 3.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs453301 0.658 rs13271797 chr8:8885954 G/A cg15556689 chr8:8085844 FLJ10661 -0.33 -8.76 -0.33 1.76e-17 Joint mobility (Beighton score); BRCA cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg25173405 chr17:45401733 C17orf57 -0.56 -12.12 -0.43 1.46e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9399135 0.967 rs59329760 chr6:135342437 G/A cg24558204 chr6:135376177 HBS1L 0.46 12.66 0.45 6.33e-33 Red blood cell count; BRCA cis rs137699 0.687 rs4821887 chr22:39756985 C/T cg11247378 chr22:39784982 NA -0.45 -8.22 -0.31 1.1e-15 IgG glycosylation; BRCA trans rs11039798 0.688 rs8188953 chr11:48749201 A/T cg15704280 chr7:45808275 SEPT13 0.59 8.84 0.33 9.53e-18 Axial length; BRCA cis rs9325144 0.600 rs61931871 chr12:38829889 G/A cg26384229 chr12:38710491 ALG10B -0.5 -11.74 -0.42 6.1e-29 Morning vs. evening chronotype; BRCA cis rs1167827 0.710 rs1167836 chr7:75168900 T/A cg04978709 chr7:75101039 POM121C 0.34 8.83 0.33 9.66e-18 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 20.35 0.63 2.32e-71 Platelet count; BRCA cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.39 -0.41 1.68e-27 Electroencephalogram traits; BRCA cis rs17270561 0.609 rs1892245 chr6:25764833 G/T cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs6089584 1.000 rs3787424 chr20:60559219 G/A cg13770153 chr20:60521292 NA -0.45 -10.71 -0.39 9.65e-25 Body mass index; BRCA cis rs9462027 0.540 rs9469867 chr6:34742449 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.89 -0.3 1.33e-14 Systemic lupus erythematosus; BRCA trans rs7618501 0.602 rs2245365 chr3:50097319 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.5 -0.35 4.15e-20 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.509 rs6849717 chr4:9958719 T/C cg02734326 chr4:10020555 SLC2A9 -0.35 -7.93 -0.3 9.93e-15 Bone mineral density; BRCA cis rs1882538 0.564 rs12707090 chr7:133115163 G/A cg10665199 chr7:133106180 EXOC4 0.44 9.09 0.34 1.22e-18 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs252915 chr5:56121754 C/T cg03609598 chr5:56110824 MAP3K1 0.48 8.38 0.31 3.48e-16 Initial pursuit acceleration; BRCA cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.24e-26 Bipolar disorder; BRCA cis rs7095944 0.614 rs3824765 chr10:126433570 C/G cg08799069 chr10:126477246 METTL10 -0.4 -9.49 -0.35 4.41e-20 Asthma; BRCA cis rs2249625 0.844 rs2496502 chr6:72885412 G/A cg18830697 chr6:72922368 RIMS1 -0.37 -7.86 -0.3 1.63e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs11958404 0.932 rs112993559 chr5:157414712 A/C cg05962755 chr5:157440814 NA 0.51 9.76 0.36 4.6e-21 IgG glycosylation; BRCA cis rs2070488 0.775 rs2268762 chr3:38516075 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.39 0.57 9.21e-56 Electrocardiographic conduction measures; BRCA cis rs2745967 0.740 rs2796253 chr1:208067409 G/A cg09788693 chr1:208063733 CD34 0.37 7.84 0.3 1.86e-14 Resting heart rate; BRCA cis rs10489202 0.608 rs7556350 chr1:168077797 C/T cg24449463 chr1:168025552 DCAF6 -0.46 -14.51 -0.5 1.88e-41 Schizophrenia; BRCA cis rs35306767 0.903 rs11253488 chr10:922482 G/C cg26597838 chr10:835615 NA 1.0 17.52 0.57 1.93e-56 Eosinophil percentage of granulocytes; BRCA cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg19077165 chr18:44547161 KATNAL2 -0.59 -13.3 -0.47 8.39e-36 Personality dimensions; BRCA cis rs9393777 0.513 rs7754159 chr6:26620312 G/A cg12292205 chr6:26970375 C6orf41 -0.49 -8.23 -0.31 1.08e-15 Intelligence (multi-trait analysis); BRCA cis rs4074536 0.574 rs10923355 chr1:116291439 T/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.66 -0.32 3.83e-17 QRS duration; BRCA cis rs13118159 0.550 rs11941200 chr4:1369093 C/G cg16405210 chr4:1374714 KIAA1530 -0.94 -20.9 -0.64 2.54e-74 Longevity; BRCA cis rs13102973 0.666 rs10007311 chr4:135898716 A/T cg14419869 chr4:135874104 NA 0.46 8.97 0.33 3.14e-18 Subjective well-being; BRCA cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg06115741 chr20:33292138 TP53INP2 0.5 10.19 0.37 1.07e-22 Coronary artery disease; BRCA cis rs3806843 0.706 rs1089305 chr5:140066306 T/C cg11822812 chr5:140052017 DND1 -0.29 -8.1 -0.31 2.75e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7264396 0.563 rs17093093 chr20:34380925 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -11.02 -0.4 5.55e-26 Total cholesterol levels; BRCA cis rs17270561 0.609 rs9379778 chr6:25687579 T/C cg16482183 chr6:26056742 HIST1H1C 0.43 8.15 0.31 1.98e-15 Iron status biomarkers; BRCA cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg27478167 chr7:817139 HEATR2 -0.57 -11.58 -0.42 2.69e-28 Cerebrospinal P-tau181p levels; BRCA cis rs7560272 0.723 rs1052161 chr2:73828538 A/G cg20560298 chr2:73613845 ALMS1 -0.4 -10.95 -0.4 1.05e-25 Schizophrenia; BRCA cis rs11098499 0.863 rs10013305 chr4:120450424 G/A cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs3796352 1.000 rs10510761 chr3:52965255 A/G cg07884673 chr3:53033167 SFMBT1 -0.73 -9.37 -0.35 1.28e-19 Immune reponse to smallpox (secreted IL-2); BRCA cis rs72781680 1.000 rs72781648 chr2:24210333 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs870825 0.616 rs56232457 chr4:185628153 T/G cg04058563 chr4:185651563 MLF1IP 0.79 17.51 0.57 2.37e-56 Blood protein levels; BRCA cis rs7385804 0.766 rs1734909 chr7:100309582 C/G cg20848291 chr7:100343083 ZAN 0.37 8.32 0.31 5.39e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs11190604 0.697 rs10748795 chr10:102194818 A/T cg07080220 chr10:102295463 HIF1AN -0.44 -9.84 -0.36 2.24e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1801251 1.000 rs7558609 chr2:233700379 C/T cg25237894 chr2:233734115 C2orf82 0.4 11.58 0.42 2.71e-28 Coronary artery disease; BRCA cis rs11690935 0.877 rs13024846 chr2:172835803 C/T cg13550731 chr2:172543902 DYNC1I2 -0.9 -28.11 -0.74 8.22e-114 Schizophrenia; BRCA cis rs858239 0.539 rs2103281 chr7:23194231 A/G cg23682824 chr7:23144976 KLHL7 0.36 9.63 0.36 1.39e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs7811142 1.000 rs7783159 chr7:100017454 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.59 8.62 0.32 5.1e-17 Platelet count; BRCA cis rs8180040 0.764 rs4682852 chr3:47177772 C/T cg27129171 chr3:47204927 SETD2 0.77 20.12 0.62 3.85e-70 Colorectal cancer; BRCA cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg20203395 chr5:56204925 C5orf35 -0.43 -9.66 -0.36 1.04e-20 Initial pursuit acceleration; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2204008 0.837 rs12370891 chr12:37984531 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.09 0.56 3.13e-54 Bladder cancer; BRCA cis rs6831352 0.879 rs2851255 chr4:100042103 C/G cg12011299 chr4:100065546 ADH4 0.48 10.9 0.4 1.65e-25 Alcohol dependence; BRCA cis rs9815354 0.812 rs17216919 chr3:41888938 G/C cg03022575 chr3:42003672 ULK4 0.68 9.46 0.35 5.93e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs8114671 0.527 rs2295352 chr20:33320055 C/G cg07148914 chr20:33460835 GGT7 -0.37 -8.09 -0.3 2.95e-15 Height; BRCA cis rs7937890 0.904 rs67623158 chr11:14295196 T/C cg22961513 chr11:14280813 SPON1 0.33 8.47 0.32 1.74e-16 Mitochondrial DNA levels; BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.11 0.31 2.54e-15 Tonsillectomy; BRCA cis rs35306767 0.715 rs1250891 chr10:1040159 G/C cg18964960 chr10:1102726 WDR37 0.63 8.67 0.32 3.6e-17 Eosinophil percentage of granulocytes; BRCA trans rs11098499 0.909 rs11098530 chr4:120413154 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.89 -0.3 1.27e-14 Corneal astigmatism; BRCA cis rs10197940 0.510 rs7602715 chr2:152421937 A/G cg19508488 chr2:152266495 RIF1 0.46 9.21 0.34 4.51e-19 Lung cancer; BRCA cis rs12410462 0.748 rs1495853 chr1:227657336 A/G cg23173402 chr1:227635558 NA -0.45 -8.33 -0.31 4.89e-16 Major depressive disorder; BRCA cis rs2836950 0.565 rs3171465 chr21:40552307 A/G cg17971929 chr21:40555470 PSMG1 -0.47 -10.48 -0.38 8.36e-24 Menarche (age at onset); BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg13047869 chr3:10149882 C3orf24 0.57 12.11 0.43 1.57e-30 Alzheimer's disease; BRCA cis rs4819052 0.918 rs34886433 chr21:46680538 G/C cg11663144 chr21:46675770 NA -0.49 -9.12 -0.34 9.98e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2635047 0.967 rs2576056 chr18:44675462 G/C cg19077165 chr18:44547161 KATNAL2 -0.4 -8.33 -0.31 4.76e-16 Educational attainment; BRCA cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg02187348 chr16:89574699 SPG7 0.4 9.27 0.34 2.85e-19 Multiple myeloma (IgH translocation); BRCA trans rs11039798 0.687 rs11499938 chr11:48957297 G/A cg15704280 chr7:45808275 SEPT13 0.6 8.94 0.33 4.02e-18 Axial length; BRCA cis rs7811142 1.000 rs11771241 chr7:99994785 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.1 19.97 0.62 2.65e-69 Platelet count; BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg21143896 chr7:2802374 GNA12 0.34 8.69 0.32 3.13e-17 Height; BRCA cis rs7959452 0.590 rs7968629 chr12:69782857 G/A cg14784868 chr12:69753453 YEATS4 0.67 19.0 0.6 3.82e-64 Blood protein levels; BRCA cis rs10824518 0.744 rs3900539 chr10:79159158 C/G cg22796248 chr10:79159275 KCNMA1 0.38 7.83 0.3 2.06e-14 Myopia; BRCA cis rs13064411 0.696 rs6787026 chr3:113162117 A/G cg18753928 chr3:113234510 CCDC52 -0.55 -9.98 -0.37 6.92e-22 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs10504073 0.669 rs57085792 chr8:50018355 T/C cg00325661 chr8:49890786 NA 0.38 11.26 0.41 5.95e-27 Blood metabolite ratios; BRCA cis rs6089829 0.962 rs2277768 chr20:61666823 T/C cg08564027 chr20:61660810 NA 0.87 23.25 0.68 4.03e-87 Prostate cancer (SNP x SNP interaction); BRCA cis rs8062405 0.690 rs7187604 chr16:28565953 A/G cg16576597 chr16:28551801 NUPR1 0.35 9.65 0.36 1.17e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs3125734 0.633 rs6479791 chr10:63980341 T/C cg09941381 chr10:64027924 RTKN2 -0.29 -8.72 -0.33 2.4e-17 Rheumatoid arthritis; BRCA cis rs8062405 1.000 rs62037367 chr16:28874547 C/G cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs3942852 0.774 rs10838813 chr11:48186969 C/A cg03929089 chr4:120376271 NA -0.48 -9.04 -0.34 1.81e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs12545109 0.800 rs1553969 chr8:57420187 A/G cg09654669 chr8:57350985 NA -0.39 -8.59 -0.32 6.42e-17 Obesity-related traits; BRCA cis rs6582630 0.502 rs8186661 chr12:38380781 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.38 0.57 1.06e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs13095912 0.785 rs6807927 chr3:185324933 A/G cg11274856 chr3:185301563 NA -0.52 -12.62 -0.45 9e-33 Systolic blood pressure; BRCA cis rs8072100 0.935 rs12943464 chr17:45690351 A/T cg25173405 chr17:45401733 C17orf57 0.48 10.01 0.37 5.22e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2540552 0.600 rs2540567 chr7:91208344 C/G cg15143024 chr7:91199642 NA 0.47 11.73 0.42 6.34e-29 IgG glycosylation; BRCA cis rs8180040 0.587 rs62246398 chr3:47066203 A/C cg16586182 chr3:47516702 SCAP 0.55 12.22 0.44 5.26e-31 Colorectal cancer; BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.33 0.35 1.64e-19 Tonsillectomy; BRCA cis rs3733585 0.699 rs4408959 chr4:9948868 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.59 -0.39 2.86e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2842992 0.830 rs2273819 chr6:160183325 G/C cg11366901 chr6:160182831 ACAT2 0.84 16.34 0.54 2e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs6701037 0.566 rs10489326 chr1:175134677 A/G cg17845761 chr1:175162550 KIAA0040 0.26 9.91 0.37 1.19e-21 Alcohol dependence; BRCA cis rs6815814 0.950 rs5743560 chr4:38806200 G/T cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs2289583 0.544 rs12050759 chr15:75265191 G/A cg10253484 chr15:75165896 SCAMP2 0.47 8.53 0.32 1.02e-16 Systemic lupus erythematosus; BRCA cis rs1048238 0.846 rs945419 chr1:16344858 C/T cg06159980 chr1:16340746 HSPB7 -0.39 -9.03 -0.34 1.95e-18 Systolic blood pressure; BRCA cis rs17270561 0.609 rs9358877 chr6:25739228 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.81e-18 Iron status biomarkers; BRCA cis rs3772130 1.000 rs11721318 chr3:121429485 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.61 0.36 1.57e-20 Cognitive performance; BRCA cis rs10927875 0.541 rs761759 chr1:16342350 A/T cg06159980 chr1:16340746 HSPB7 -0.38 -8.84 -0.33 9.14e-18 Dilated cardiomyopathy; BRCA cis rs477692 0.905 rs570967 chr10:131421330 T/G cg24747557 chr10:131355152 MGMT -0.31 -7.91 -0.3 1.12e-14 Response to temozolomide; BRCA cis rs4808199 0.901 rs11669516 chr19:19532682 G/A cg03709012 chr19:19516395 GATAD2A 1.09 21.52 0.65 1.2e-77 Nonalcoholic fatty liver disease; BRCA trans rs7618501 0.633 rs11130234 chr3:50024758 G/T cg21659725 chr3:3221576 CRBN 0.48 12.09 0.43 1.86e-30 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.02 17.89 0.58 2.45e-58 Platelet count; BRCA cis rs7267979 1.000 rs2259837 chr20:25280205 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.2e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs35306767 0.855 rs55697724 chr10:885622 T/C cg26597838 chr10:835615 NA 1.32 22.06 0.66 1.34e-80 Eosinophil percentage of granulocytes; BRCA cis rs8014204 0.657 rs2884668 chr14:75281576 T/A cg06637938 chr14:75390232 RPS6KL1 0.43 8.9 0.33 5.54e-18 Caffeine consumption; BRCA cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg10523679 chr1:76189770 ACADM -0.49 -9.54 -0.35 2.99e-20 Daytime sleep phenotypes; BRCA cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg08493051 chr2:3487164 NA -0.43 -9.25 -0.34 3.33e-19 Neurofibrillary tangles; BRCA cis rs6912958 1.000 rs6933587 chr6:88175577 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -9.2 -0.34 4.95e-19 Monocyte percentage of white cells; BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg04944784 chr2:26401820 FAM59B 0.99 16.67 0.55 4.37e-52 Gut microbiome composition (summer); BRCA cis rs3806843 1.000 rs1548700 chr5:140164889 A/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.53 -0.35 3.1e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs2191566 0.576 rs393195 chr19:44493142 T/G cg20607764 chr19:44506953 ZNF230 0.38 8.33 0.31 5.06e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs13095912 0.785 rs6800725 chr3:185298156 C/A cg11274856 chr3:185301563 NA 0.56 13.58 0.47 4.54e-37 Systolic blood pressure; BRCA cis rs7811142 0.943 rs3900792 chr7:100004577 C/G cg11814155 chr7:99998594 ZCWPW1 0.47 8.52 0.32 1.16e-16 Platelet count; BRCA cis rs7412746 0.622 rs72704654 chr1:150826410 G/A cg18016565 chr1:150552671 MCL1 0.35 8.03 0.3 4.85e-15 Melanoma; BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.96 0.33 3.51e-18 Tonsillectomy; BRCA cis rs7103648 0.838 rs11039244 chr11:47466442 G/A cg03711944 chr11:47377212 SPI1 -0.37 -9.31 -0.35 2.04e-19 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6089584 0.527 rs927589 chr20:60606363 A/G cg06108461 chr20:60628389 TAF4 -0.71 -14.85 -0.51 4.36e-43 Body mass index; BRCA cis rs4819052 0.807 rs4819047 chr21:46665139 C/T cg11663144 chr21:46675770 NA -0.61 -14.24 -0.49 3.65e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs698813 0.851 rs698807 chr2:44701659 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.2 0.34 5.1e-19 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg12386194 chr3:101231763 SENP7 0.46 9.85 0.36 2.01e-21 Colorectal cancer; BRCA cis rs6964587 1.000 rs10281556 chr7:91660053 C/T cg17063962 chr7:91808500 NA -0.52 -12.25 -0.44 3.9e-31 Breast cancer; BRCA cis rs6545883 0.894 rs35292974 chr2:61522047 T/C cg15711740 chr2:61764176 XPO1 0.52 13.23 0.46 1.68e-35 Tuberculosis; BRCA trans rs11098499 0.645 rs72676059 chr4:120290828 C/G cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs4268898 0.552 rs12620938 chr2:24367122 C/A cg26838691 chr2:24397539 C2orf84 0.39 7.96 0.3 8.05e-15 Asthma; BRCA cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22307029 chr19:49891270 CCDC155 0.61 10.85 0.39 2.84e-25 Multiple sclerosis; BRCA cis rs425277 1.000 rs262651 chr1:2091397 A/G cg00981070 chr1:2046702 PRKCZ 0.31 8.21 0.31 1.24e-15 Height; BRCA cis rs798554 1.000 rs798536 chr7:2766383 G/A cg21143896 chr7:2802374 GNA12 -0.35 -8.45 -0.32 2e-16 Height; BRCA cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.65e-23 Motion sickness; BRCA cis rs6430585 0.702 rs746857 chr2:136554890 G/A cg07169764 chr2:136633963 MCM6 -1.16 -25.42 -0.71 5.08e-99 Corneal structure; BRCA cis rs7592578 0.679 rs4287794 chr2:191327147 T/C cg10560079 chr2:191398806 TMEM194B -0.65 -12.47 -0.44 4.17e-32 Diastolic blood pressure; BRCA cis rs1577917 0.916 rs7759727 chr6:86518878 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.21e-29 Response to antipsychotic treatment; BRCA cis rs826838 0.933 rs1906263 chr12:38653362 T/C cg13010199 chr12:38710504 ALG10B 0.57 12.46 0.44 4.82e-32 Heart rate; BRCA cis rs13191362 0.935 rs67673890 chr6:163107647 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.44 0.32 2.17e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs16958440 1.000 rs62096464 chr18:44629207 T/A cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs6582630 0.638 rs7963994 chr12:38555535 G/A cg26384229 chr12:38710491 ALG10B -0.45 -10.4 -0.38 1.62e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs250677 0.687 rs41181 chr5:148444257 C/G cg12140854 chr5:148520817 ABLIM3 0.41 8.61 0.32 5.87e-17 Breast cancer; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs7727544 0.647 rs6898270 chr5:131421190 C/T cg14196790 chr5:131705035 SLC22A5 0.37 9.07 0.34 1.4e-18 Blood metabolite levels; BRCA cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg10792982 chr14:105748885 BRF1 0.46 10.74 0.39 7.66e-25 Mean platelet volume;Platelet distribution width; BRCA cis rs853679 0.517 rs35193936 chr6:28076270 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.32 -0.31 5.27e-16 Depression; BRCA cis rs6831352 0.879 rs29001212 chr4:100051877 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs4237845 0.780 rs3751331 chr12:58290278 G/A cg00677455 chr12:58241039 CTDSP2 0.54 12.63 0.45 8.58e-33 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.931 rs9876848 chr3:48844059 G/A cg06212747 chr3:49208901 KLHDC8B 0.47 9.53 0.35 3.25e-20 Parkinson's disease; BRCA cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg23625390 chr15:77176239 SCAPER 0.41 10.02 0.37 4.84e-22 Blood metabolite levels; BRCA cis rs6545883 0.895 rs7588814 chr2:61695589 A/T cg15711740 chr2:61764176 XPO1 -0.53 -13.37 -0.47 3.92e-36 Tuberculosis; BRCA cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg08975724 chr8:8085496 FLJ10661 0.48 10.23 0.38 7.76e-23 Mood instability; BRCA cis rs77633900 0.614 rs280013 chr15:76978139 C/T cg21673338 chr15:77095150 SCAPER 0.54 9.73 0.36 5.85e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg15017067 chr4:17643749 FAM184B 0.29 8.91 0.33 5.26e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2204008 0.776 rs3861074 chr12:38483021 C/T cg13010199 chr12:38710504 ALG10B 0.51 9.82 0.36 2.6e-21 Bladder cancer; BRCA cis rs1534166 0.647 rs9853615 chr3:133519981 C/T cg01448562 chr3:133502909 NA -0.4 -9.11 -0.34 1.03e-18 Alcohol consumption (transferrin glycosylation); BRCA cis rs801193 0.773 rs801207 chr7:66020590 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.7 -0.33 2.7e-17 Aortic root size; BRCA cis rs1005277 0.540 rs7903942 chr10:37929276 C/T cg25427524 chr10:38739819 LOC399744 0.63 14.2 0.49 5.7e-40 Extrinsic epigenetic age acceleration; BRCA cis rs5758659 0.714 rs133373 chr22:42465788 G/A cg15557168 chr22:42548783 NA -0.32 -8.83 -0.33 9.79e-18 Cognitive function; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg00166722 chr3:10149974 C3orf24 0.65 12.86 0.45 8.28e-34 Alzheimer's disease; BRCA cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg00981070 chr1:2046702 PRKCZ 0.26 8.04 0.3 4.51e-15 Height; BRCA cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg05283184 chr6:79620031 NA -0.41 -10.63 -0.39 2.12e-24 Intelligence (multi-trait analysis); BRCA cis rs56104184 0.775 rs73061692 chr19:49399676 T/C cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.71 -0.36 7.17e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs1059312 1.000 rs12814773 chr12:129280786 C/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.13 0.34 8.96e-19 Systemic lupus erythematosus; BRCA cis rs17376456 0.877 rs12716460 chr5:93416733 A/G cg25358565 chr5:93447407 FAM172A 1.2 18.84 0.6 2.54e-63 Diabetic retinopathy; BRCA cis rs11605275 1.000 rs77993017 chr11:20031388 C/G cg14835545 chr11:20032148 NAV2 -0.59 -9.32 -0.35 1.87e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs875971 0.862 rs10276077 chr7:65728411 A/G cg18876405 chr7:65276391 NA -0.51 -11.64 -0.42 1.56e-28 Aortic root size; BRCA cis rs6952808 0.931 rs12537430 chr7:1868761 A/G cg08061076 chr7:1943177 MAD1L1 0.35 8.01 0.3 5.57e-15 Bipolar disorder and schizophrenia; BRCA cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg11530693 chr1:120165357 ZNF697 0.62 14.94 0.51 1.68e-43 Systemic lupus erythematosus; BRCA cis rs2806561 0.514 rs10917360 chr1:23539010 C/T cg19743168 chr1:23544995 NA 0.69 17.43 0.57 5.77e-56 Height; BRCA cis rs868036 0.881 rs12708496 chr15:68054098 T/C cg05925327 chr15:68127851 NA 0.34 8.53 0.32 1.06e-16 Restless legs syndrome; BRCA cis rs4595586 0.545 rs4411311 chr12:39363612 C/G cg26384229 chr12:38710491 ALG10B 0.42 9.32 0.35 1.91e-19 Morning vs. evening chronotype; BRCA cis rs67311347 0.713 rs4974018 chr3:40307419 G/A cg09455208 chr3:40491958 NA 0.41 9.64 0.36 1.22e-20 Renal cell carcinoma; BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26314531 chr2:26401878 FAM59B 0.9 16.24 0.54 6.54e-50 Gut microbiome composition (summer); BRCA cis rs2842992 0.789 rs2342446 chr6:160220687 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.83 0.58 5.12e-58 Age-related macular degeneration (geographic atrophy); BRCA cis rs6088580 0.634 rs2184836 chr20:32963369 A/G cg08999081 chr20:33150536 PIGU -0.47 -12.84 -0.45 9.74e-34 Glomerular filtration rate (creatinine); BRCA cis rs727479 0.543 rs12900487 chr15:51523159 T/C cg19946085 chr15:51559439 CYP19A1 -0.29 -7.96 -0.3 7.98e-15 Estradiol levels; BRCA cis rs921968 0.541 rs4674308 chr2:219310483 A/C cg02176678 chr2:219576539 TTLL4 0.47 12.15 0.43 1.01e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs832540 0.931 rs33318 chr5:56208414 G/T cg24531977 chr5:56204891 C5orf35 -0.42 -8.44 -0.32 2.16e-16 Coronary artery disease; BRCA trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.97 -0.3 7.12e-15 Corneal astigmatism; BRCA cis rs13046373 0.505 rs2832962 chr21:32008332 T/C cg16431978 chr21:31797932 KRTAP13-3 0.36 8.97 0.33 3.26e-18 HDL cholesterol; BRCA cis rs68170813 0.559 rs2189501 chr7:106942766 A/T cg02696742 chr7:106810147 HBP1 -0.53 -8.68 -0.32 3.38e-17 Coronary artery disease; BRCA cis rs910316 1.000 rs175443 chr14:75601963 C/T cg11812906 chr14:75593930 NEK9 -0.61 -13.97 -0.48 7e-39 Height; BRCA cis rs6831352 0.918 rs29001214 chr4:100051733 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs9467773 1.000 rs3736782 chr6:26505403 C/A cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.23e-60 Intelligence (multi-trait analysis); BRCA cis rs6910061 1.000 rs13214666 chr6:11103537 C/A cg27233058 chr6:11094804 LOC221710 0.54 9.62 0.36 1.54e-20 Diabetic kidney disease; BRCA cis rs2070488 1.000 rs7373805 chr3:38455439 C/T cg24069376 chr3:38537580 EXOG 0.4 11.4 0.41 1.51e-27 Electrocardiographic conduction measures; BRCA cis rs4363385 0.747 rs1338180 chr1:152981404 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.35 -0.31 4.24e-16 Inflammatory skin disease; BRCA cis rs4730250 0.708 rs3801965 chr7:106825628 G/T cg02696742 chr7:106810147 HBP1 -0.53 -8.41 -0.32 2.73e-16 Osteoarthritis; BRCA cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs12541635 0.966 rs55762012 chr8:107033218 T/C cg10147462 chr8:107024639 NA 0.36 9.39 0.35 1.02e-19 Age of smoking initiation; BRCA cis rs1153858 1.000 rs67461176 chr15:45676819 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.63 0.42 1.63e-28 Homoarginine levels; BRCA cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.93 0.4 1.28e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3750965 0.959 rs4930265 chr11:68855954 A/G cg06818126 chr11:68850279 TPCN2 -0.35 -8.41 -0.32 2.75e-16 Hair color; BRCA cis rs6820391 0.781 rs7680855 chr4:54447248 G/A cg04173182 chr4:54446035 LNX1 0.53 11.76 0.42 4.8e-29 Cervical artery dissection; BRCA cis rs763121 0.853 rs138712 chr22:39141600 C/T cg06544989 chr22:39130855 UNC84B 0.39 9.37 0.35 1.23e-19 Menopause (age at onset); BRCA cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.85 0.42 1.97e-29 Homoarginine levels; BRCA cis rs28595532 0.920 rs116023902 chr4:119725131 A/G cg21605333 chr4:119757512 SEC24D 1.34 13.89 0.48 1.64e-38 Cannabis dependence symptom count; BRCA cis rs12701220 0.655 rs10215292 chr7:1135263 A/G cg04025307 chr7:1156635 C7orf50 0.47 9.24 0.34 3.52e-19 Bronchopulmonary dysplasia; BRCA cis rs950776 0.684 rs692780 chr15:78876505 C/G cg06917634 chr15:78832804 PSMA4 -0.62 -13.27 -0.46 1.1e-35 Sudden cardiac arrest; BRCA cis rs9467711 0.591 rs60512607 chr6:26054171 T/A cg08501292 chr6:25962987 TRIM38 0.59 8.25 0.31 9.02e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs2576037 0.796 rs2571030 chr18:44573854 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -8.98 -0.33 2.97e-18 Personality dimensions; BRCA cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg10596483 chr8:143751796 JRK -0.45 -9.44 -0.35 6.92e-20 Schizophrenia; BRCA cis rs7246657 0.943 rs10417844 chr19:37837587 C/T cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs9311474 1.000 rs7614727 chr3:52295895 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.27 8.45 0.32 2.02e-16 Electroencephalogram traits; BRCA cis rs17253792 0.822 rs10148983 chr14:56051879 A/G cg01858014 chr14:56050164 KTN1 -0.77 -11.14 -0.4 1.75e-26 Putamen volume; BRCA cis rs6964587 1.000 rs13231578 chr7:91663266 C/T cg17063962 chr7:91808500 NA 0.51 11.99 0.43 5.18e-30 Breast cancer; BRCA cis rs9287719 0.967 rs4669599 chr2:10758029 T/C cg00105475 chr2:10696890 NA 0.44 10.29 0.38 4.38e-23 Prostate cancer; BRCA cis rs939658 1.000 rs12439908 chr15:79456381 T/C cg17916960 chr15:79447300 NA 0.39 9.83 0.36 2.55e-21 Refractive error; BRCA cis rs7833986 0.501 rs72653941 chr8:56942247 T/C cg26371346 chr8:56986568 SNORD54;RPS20 0.44 7.89 0.3 1.27e-14 Height; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg02951883 chr7:2050386 MAD1L1 -0.62 -15.74 -0.53 1.97e-47 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg05283184 chr6:79620031 NA -0.37 -8.64 -0.32 4.48e-17 Intelligence (multi-trait analysis); BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg13628971 chr7:2884303 GNA12 0.47 9.02 0.34 2.14e-18 Height; BRCA cis rs3096299 0.719 rs2965945 chr16:89514017 T/C cg02187348 chr16:89574699 SPG7 0.48 11.28 0.41 4.72e-27 Multiple myeloma (IgH translocation); BRCA cis rs10493773 0.532 rs1889919 chr1:86180034 A/G cg17807903 chr1:86174739 ZNHIT6 -0.59 -15.78 -0.53 1.23e-47 Urate levels in overweight individuals; BRCA cis rs495337 1.000 rs486206 chr20:48516733 C/G cg17835207 chr20:48524531 SPATA2 -0.64 -14.6 -0.5 6.85e-42 Psoriasis; BRCA cis rs897080 0.515 rs1085488 chr2:44618004 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.45 8.67 0.32 3.57e-17 Height; BRCA cis rs2204008 0.643 rs1315347 chr12:38162494 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.03 -0.37 4.43e-22 Bladder cancer; BRCA cis rs1005277 0.579 rs1621040 chr10:38497232 T/C cg18963800 chr10:38644991 HSD17B7P2 -0.41 -7.98 -0.3 6.83e-15 Extrinsic epigenetic age acceleration; BRCA cis rs1538970 0.924 rs7531253 chr1:45890183 T/C cg05343316 chr1:45956843 TESK2 0.62 12.48 0.44 3.73e-32 Platelet count; BRCA cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg23583168 chr7:148888333 NA -0.8 -19.11 -0.6 9.56e-65 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9816226 0.938 rs55742087 chr3:185830488 C/T cg00760338 chr3:185826511 ETV5 -0.53 -8.98 -0.33 2.99e-18 Obesity;Body mass index; BRCA cis rs7766436 0.885 rs11759879 chr6:22587130 C/T cg13666174 chr6:22585274 NA -0.45 -9.79 -0.36 3.47e-21 Coronary artery disease; BRCA cis rs6570726 0.764 rs451108 chr6:145844309 T/C cg05347473 chr6:146136440 FBXO30 0.4 7.9 0.3 1.27e-14 Lobe attachment (rater-scored or self-reported); BRCA trans rs1945213 0.694 rs34390414 chr11:55863367 T/G cg03929089 chr4:120376271 NA 0.57 9.88 0.36 1.61e-21 Acute lymphoblastic leukemia (childhood); BRCA trans rs35110281 0.627 rs1595167 chr21:44965874 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.06 0.37 3.5e-22 Mean corpuscular volume; BRCA trans rs1829883 0.804 rs2511924 chr5:98721643 C/T cg08333243 chr5:99726346 NA 0.34 8.41 0.32 2.72e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs6460942 0.915 rs62448600 chr7:12454944 T/G cg06484146 chr7:12443880 VWDE -0.75 -10.68 -0.39 1.35e-24 Coronary artery disease; BRCA cis rs9457247 0.602 rs12209395 chr6:167463914 C/T cg07741184 chr6:167504864 NA 0.34 9.79 0.36 3.57e-21 Crohn's disease; BRCA cis rs896854 0.631 rs10097617 chr8:95961626 T/C cg16049864 chr8:95962084 TP53INP1 -0.49 -12.25 -0.44 3.77e-31 Type 2 diabetes; BRCA cis rs40363 0.645 rs250629 chr16:3525431 C/A cg05754148 chr16:3507555 NAT15 0.38 8.05 0.3 4.02e-15 Tuberculosis; BRCA cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg18512352 chr11:47633146 NA -0.33 -7.97 -0.3 7.07e-15 Subjective well-being; BRCA cis rs6547741 1.000 rs1528402 chr2:27857517 G/A cg27432699 chr2:27873401 GPN1 0.43 9.19 0.34 5.65e-19 Oral cavity cancer; BRCA cis rs6964587 1.000 rs2075881 chr7:91734552 T/C cg17063962 chr7:91808500 NA 0.59 13.94 0.48 9.79e-39 Breast cancer; BRCA cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.67 0.39 1.44e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs11211223 chr1:46380605 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.65 0.39 1.71e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4478858 0.698 rs4949385 chr1:31793256 C/T cg00250761 chr1:31883323 NA -0.33 -8.54 -0.32 9.92e-17 Alcohol dependence; BRCA cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.21 0.37 9.11e-23 Bipolar disorder; BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg00149659 chr3:10157352 C3orf10 -1.08 -18.55 -0.59 8.53e-62 Alzheimer's disease; BRCA cis rs7394190 0.748 rs11000772 chr10:75533988 T/G cg07699608 chr10:75541558 CHCHD1 0.65 9.64 0.36 1.26e-20 Incident atrial fibrillation; BRCA cis rs4690686 0.500 rs2168032 chr4:177272957 A/G cg17059388 chr4:177262070 NA 0.51 10.71 0.39 9.86e-25 Essential tremor; BRCA cis rs4808199 0.947 rs754255 chr19:19578890 T/C cg03709012 chr19:19516395 GATAD2A 1.07 21.12 0.64 1.62e-75 Nonalcoholic fatty liver disease; BRCA cis rs7552404 0.960 rs12134854 chr1:76137606 A/G cg03433033 chr1:76189801 ACADM 0.72 16.63 0.55 7.58e-52 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs61931739 0.500 rs11053235 chr12:34507899 G/A cg06521331 chr12:34319734 NA -0.56 -10.0 -0.37 5.64e-22 Morning vs. evening chronotype; BRCA cis rs853679 0.517 rs4713145 chr6:28106827 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.16 0.31 1.83e-15 Depression; BRCA cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg08885076 chr2:99613938 TSGA10 0.44 10.2 0.37 1.02e-22 Chronic sinus infection; BRCA cis rs172166 0.611 rs203882 chr6:28078502 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.02 0.3 5.21e-15 Cardiac Troponin-T levels; BRCA cis rs477692 0.905 rs576560 chr10:131420697 C/A cg05714579 chr10:131428358 MGMT 0.57 14.08 0.49 2.01e-39 Response to temozolomide; BRCA cis rs9837602 0.810 rs35777905 chr3:99690970 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.58 8.71 0.33 2.5e-17 Breast cancer; BRCA cis rs7481584 0.581 rs366422 chr11:3053873 C/T cg08508325 chr11:3079039 CARS 0.28 8.43 0.32 2.22e-16 Calcium levels; BRCA cis rs262150 0.579 rs4481540 chr7:158785846 A/G cg17987982 chr7:158820591 NA -0.43 -8.17 -0.31 1.65e-15 Facial morphology (factor 20); BRCA cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg11890956 chr21:40555474 PSMG1 0.96 24.24 0.69 1.45e-92 Cognitive function; BRCA cis rs9443645 0.901 rs4421161 chr6:79564219 A/G cg18132916 chr6:79620363 NA 0.48 10.58 0.39 3.33e-24 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg22920501 chr2:26401640 FAM59B -0.67 -11.61 -0.42 2.04e-28 Gut microbiome composition (summer); BRCA cis rs796364 0.901 rs35572201 chr2:201035093 T/C cg23649088 chr2:200775458 C2orf69 -0.64 -10.38 -0.38 1.99e-23 Schizophrenia; BRCA cis rs9527 0.640 rs35195396 chr10:104928770 T/A cg04362960 chr10:104952993 NT5C2 0.44 10.12 0.37 1.97e-22 Arsenic metabolism; BRCA cis rs78456975 0.622 rs11888851 chr2:1518254 C/G cg12573674 chr2:1569213 NA -0.41 -8.17 -0.31 1.61e-15 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3784262 0.533 rs12148525 chr15:58196456 A/G cg12031962 chr15:58353849 ALDH1A2 0.34 8.04 0.3 4.5e-15 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2204008 0.640 rs2320744 chr12:38162389 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs2153535 0.580 rs7753192 chr6:8482637 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.68e-18 Motion sickness; BRCA cis rs12701220 0.744 rs10499317 chr7:1012103 C/G cg06145435 chr7:1022769 CYP2W1 0.42 9.03 0.34 2.03e-18 Bronchopulmonary dysplasia; BRCA cis rs17376456 0.877 rs12374463 chr5:93483569 C/G cg25358565 chr5:93447407 FAM172A 1.24 19.21 0.61 2.89e-65 Diabetic retinopathy; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg04518342 chr5:131593106 PDLIM4 -0.4 -9.41 -0.35 8.68e-20 Acylcarnitine levels; BRCA cis rs367943 0.799 rs2115209 chr5:112973494 A/G cg12552261 chr5:112820674 MCC 0.5 9.9 0.36 1.3e-21 Type 2 diabetes; BRCA cis rs17092148 0.790 rs6058079 chr20:33142873 G/A cg16810054 chr20:33298113 TP53INP2 -0.45 -10.08 -0.37 2.74e-22 Neuroticism; BRCA cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 8.1 0.31 2.78e-15 Educational attainment; BRCA trans rs3960554 0.808 rs57721466 chr7:75710049 C/T cg19862616 chr7:65841803 NCRNA00174 0.6 11.98 0.43 5.53e-30 Eotaxin levels; BRCA cis rs17253792 0.545 rs3742571 chr14:56016704 A/G cg01858014 chr14:56050164 KTN1 -0.6 -7.87 -0.3 1.57e-14 Putamen volume; BRCA cis rs2839186 0.619 rs55689527 chr21:47622727 A/G cg12379764 chr21:47803548 PCNT -0.39 -8.51 -0.32 1.2e-16 Testicular germ cell tumor; BRCA cis rs9733 0.593 rs10888384 chr1:150574256 C/T cg13175981 chr1:150552382 MCL1 0.48 10.72 0.39 8.79e-25 Tonsillectomy; BRCA cis rs11958404 0.932 rs72816549 chr5:157417957 G/A cg05962755 chr5:157440814 NA 0.5 9.57 0.35 2.34e-20 IgG glycosylation; BRCA cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg22529645 chr1:3704559 LRRC47 0.28 8.47 0.32 1.67e-16 Red cell distribution width; BRCA cis rs10845606 1.000 rs10845605 chr12:12833468 T/C cg04607235 chr12:12878440 APOLD1 -0.62 -9.91 -0.37 1.21e-21 Systemic lupus erythematosus; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg18765753 chr7:1198926 ZFAND2A -0.37 -8.32 -0.31 5.42e-16 Longevity;Endometriosis; BRCA cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs12200560 0.505 rs984520 chr6:97076454 A/G cg06623918 chr6:96969491 KIAA0776 -0.54 -13.09 -0.46 7.64e-35 Coronary heart disease; BRCA cis rs9649213 0.574 rs60077733 chr7:97970137 C/T cg01877450 chr7:97915802 BRI3 -0.41 -8.68 -0.32 3.38e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg18200150 chr17:30822561 MYO1D -0.5 -13.29 -0.47 9e-36 Schizophrenia; BRCA trans rs7618501 1.000 rs7374183 chr3:49785133 G/A cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.41 -0.38 1.46e-23 Intelligence (multi-trait analysis); BRCA cis rs910316 0.737 rs175084 chr14:75519175 C/T cg11812906 chr14:75593930 NEK9 -0.6 -13.47 -0.47 1.34e-36 Height; BRCA cis rs12586317 0.553 rs3809448 chr14:35515096 C/T cg05294307 chr14:35346193 BAZ1A -0.63 -10.64 -0.39 1.95e-24 Psoriasis; BRCA cis rs10504229 0.769 rs17804383 chr8:58151830 A/G cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs7715811 1.000 rs1502042 chr5:13758344 G/A cg07548982 chr5:13769939 DNAH5 -0.38 -8.37 -0.31 3.64e-16 Subclinical atherosclerosis traits (other); BRCA cis rs17270561 0.609 rs9358885 chr6:25758024 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.83 0.33 1.01e-17 Iron status biomarkers; BRCA cis rs3806843 1.000 rs10053586 chr5:140210760 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.95 -0.37 8.59e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs7520050 0.966 rs11211208 chr1:46334256 A/C cg24296786 chr1:45957014 TESK2 0.44 9.92 0.37 1.18e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg10150615 chr22:24372951 LOC391322 0.44 9.83 0.36 2.51e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6964587 0.692 rs10227225 chr7:91571074 A/G cg17063962 chr7:91808500 NA -0.56 -12.65 -0.45 6.91e-33 Breast cancer; BRCA cis rs3917254 0.543 rs6543106 chr2:102746449 A/G cg22835712 chr2:102737379 NA -0.55 -9.26 -0.34 3.02e-19 Blood protein levels; BRCA cis rs4561483 0.801 rs251723 chr16:11953080 G/C cg08843971 chr16:11963173 GSPT1 -0.51 -11.42 -0.41 1.26e-27 Testicular germ cell tumor; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg19723775 chr5:179050963 HNRNPH1 0.37 9.07 0.34 1.43e-18 Lung cancer; BRCA cis rs7666738 0.962 rs4699596 chr4:99012924 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.48 0.32 1.52e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.748 rs2838324 chr21:44999820 T/C cg04455712 chr21:45112962 RRP1B 0.41 10.39 0.38 1.78e-23 Mean corpuscular volume; BRCA cis rs2832077 0.943 rs2832100 chr21:30175628 A/C cg24692254 chr21:30365293 RNF160 -0.48 -8.53 -0.32 1.05e-16 Cognitive test performance; BRCA cis rs3806843 0.735 rs2563306 chr5:140070017 C/T cg26395211 chr5:140044315 WDR55 0.37 8.52 0.32 1.16e-16 Depressive symptoms (multi-trait analysis); BRCA trans rs12517041 0.935 rs1428628 chr5:23311925 T/A ch.8.1293020R chr8:59333349 UBXN2B -0.48 -8.5 -0.32 1.38e-16 Calcium levels; BRCA cis rs7811142 1.000 rs7794485 chr7:100068936 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 8.39 0.32 3.09e-16 Platelet count; BRCA cis rs9287719 0.967 rs4453662 chr2:10739128 G/A cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs9287719 0.967 rs6727768 chr2:10757479 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.16 -0.31 1.79e-15 Prostate cancer; BRCA cis rs13382862 0.895 rs13385499 chr2:20882413 A/G cg07755735 chr2:20870362 GDF7 -0.35 -8.61 -0.32 5.73e-17 Abdominal aortic aneurysm; BRCA cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.58 -0.32 7.15e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2645694 0.533 rs2645680 chr4:77820956 T/C cg03477792 chr4:77819574 ANKRD56 0.62 14.97 0.51 1.22e-43 Emphysema distribution in smoking; BRCA cis rs7246657 0.722 rs8100646 chr19:38107943 T/C cg23950597 chr19:37808831 NA -0.48 -8.23 -0.31 1.06e-15 Coronary artery calcification; BRCA cis rs17376456 0.877 rs13153245 chr5:93374891 G/A cg25358565 chr5:93447407 FAM172A 1.17 18.45 0.59 3.07e-61 Diabetic retinopathy; BRCA cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg05623727 chr3:50126028 RBM5 0.42 9.94 0.37 9.6e-22 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.808 rs2838825 chr21:46655651 C/T cg11663144 chr21:46675770 NA -0.57 -13.32 -0.47 7.04e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs929596 0.606 rs7604115 chr2:234658116 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -10.79 -0.39 4.79e-25 Total bilirubin levels in HIV-1 infection; BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.11 0.34 1.01e-18 Platelet count; BRCA trans rs11976180 1.000 rs2961128 chr7:143763483 A/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA trans rs6076960 0.684 rs3909041 chr20:6249598 C/G cg21095983 chr6:86352623 SYNCRIP 0.42 9.06 0.34 1.53e-18 Smooth-surface caries; BRCA cis rs4891159 0.526 rs2848961 chr18:74129886 C/G cg24786174 chr18:74118243 ZNF516 -0.8 -22.94 -0.67 1.93e-85 Longevity; BRCA cis rs365132 1.000 rs353464 chr5:176403023 A/G cg16309518 chr5:176445507 NA -0.52 -13.42 -0.47 2.31e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7818345 1.000 rs7823194 chr8:19292528 C/T cg11303988 chr8:19266685 CSGALNACT1 0.31 8.04 0.3 4.3e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs7903847 0.642 rs1537646 chr10:99149922 T/C cg08345082 chr10:99160200 RRP12 -0.31 -9.09 -0.34 1.28e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs13191362 0.935 rs66962088 chr6:162963891 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.84 0.45 9.71e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10044254 0.563 rs6554897 chr5:15695253 A/G cg07238450 chr5:15720153 FBXL7 -0.38 -7.81 -0.3 2.32e-14 Asthma (corticosteroid response); BRCA cis rs4820294 1.000 rs62236667 chr22:38061520 C/G cg21798802 chr22:38057573 PDXP 0.48 12.94 0.46 3.47e-34 Fat distribution (HIV); BRCA cis rs2204008 0.818 rs1589389 chr12:38416041 G/A cg13010199 chr12:38710504 ALG10B -0.38 -7.99 -0.3 6.34e-15 Bladder cancer; BRCA cis rs1707322 1.000 rs6671754 chr1:46433990 A/G cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg24846343 chr22:24311635 DDTL 0.54 14.16 0.49 9.11e-40 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs208520 0.690 rs851459 chr6:66813989 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.99 -0.64 8.24e-75 Exhaled nitric oxide output; BRCA cis rs9354352 0.967 rs6455062 chr6:66694131 T/A cg07460842 chr6:66804631 NA 0.64 13.82 0.48 3.46e-38 Initial pursuit acceleration in psychotic disorders; BRCA cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2882667 0.822 rs11738376 chr5:138398172 G/A cg04439458 chr5:138467593 SIL1 -0.43 -10.87 -0.4 2.2e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7267979 1.000 rs6037095 chr20:25335687 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.11 -0.34 1.06e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.54 0.47 6.44e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA trans rs2834485 0.816 rs1547356 chr21:35822572 C/T cg07474852 chr4:123073612 NA 0.41 8.21 0.31 1.27e-15 Cancer; BRCA cis rs9470366 0.816 rs7742159 chr6:36619452 A/C cg08179530 chr6:36648295 CDKN1A 0.5 9.99 0.37 6.13e-22 QRS duration; BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg22963979 chr7:1858916 MAD1L1 0.46 9.31 0.35 2.06e-19 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.8e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs528301 0.584 rs7604640 chr2:45121466 G/A cg02372786 chr2:45167549 SIX3 -0.42 -9.25 -0.34 3.34e-19 Alcohol and nicotine co-dependence; BRCA cis rs1401999 0.714 rs13066518 chr3:183635498 T/A cg20387954 chr3:183756860 HTR3D 0.39 8.92 0.33 4.74e-18 Anterior chamber depth; BRCA trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.32 0.35 1.85e-19 Morning vs. evening chronotype; BRCA cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg20607287 chr7:12443886 VWDE -0.57 -8.31 -0.31 5.93e-16 Coronary artery disease; BRCA cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg05868516 chr6:26286170 HIST1H4H 0.5 11.25 0.41 6.6e-27 Educational attainment; BRCA cis rs7552404 0.924 rs2275378 chr1:76198436 T/C cg22875332 chr1:76189707 ACADM 0.81 19.72 0.62 5.72e-68 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.66 11.53 0.41 4.48e-28 Platelet count; BRCA cis rs7772486 0.846 rs6908063 chr6:146403618 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -8.51 -0.32 1.2e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg23625390 chr15:77176239 SCAPER 0.41 10.2 0.37 9.44e-23 Blood metabolite levels; BRCA cis rs703842 0.963 rs2069506 chr12:58142854 C/A cg00677455 chr12:58241039 CTDSP2 0.59 13.07 0.46 8.71e-35 Multiple sclerosis; BRCA trans rs7395662 0.525 rs4882060 chr11:48441874 G/C cg15704280 chr7:45808275 SEPT13 -0.42 -8.17 -0.31 1.66e-15 HDL cholesterol; BRCA cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg26597838 chr10:835615 NA 0.98 14.98 0.51 1.07e-43 Eosinophil percentage of granulocytes; BRCA cis rs12142240 0.698 rs55971480 chr1:46823206 G/T cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs1568889 0.838 rs1483858 chr11:28189639 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.41 0.63 1.15e-71 Bipolar disorder; BRCA cis rs941873 0.772 rs1892498 chr10:81103862 A/G cg09469691 chr10:81107165 PPIF 0.49 10.3 0.38 3.86e-23 Height; BRCA cis rs765787 0.530 rs11854690 chr15:45516016 C/T cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs7737355 1.000 rs12654593 chr5:130756867 C/T cg06307176 chr5:131281290 NA -0.51 -9.97 -0.37 7.4e-22 Life satisfaction; BRCA cis rs2625529 0.586 rs59975112 chr15:72423710 G/T cg16672083 chr15:72433130 SENP8 0.67 16.38 0.54 1.25e-50 Red blood cell count; BRCA cis rs12477438 0.798 rs9808541 chr2:99642179 A/T cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs2153535 0.580 rs7341201 chr6:8470270 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs4819052 0.851 rs914214 chr21:46697820 G/T cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4389656 0.740 rs274706 chr5:6726629 T/C cg10857441 chr5:6722123 POLS -0.25 -7.82 -0.3 2.21e-14 Coronary artery disease; BRCA cis rs10911232 0.507 rs10752891 chr1:183023283 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.69 0.55 3.53e-52 Hypertriglyceridemia; BRCA cis rs62380364 0.602 rs650702 chr5:88055313 G/A cg22951263 chr5:87985283 NA -0.38 -10.65 -0.39 1.69e-24 Intelligence (multi-trait analysis); BRCA cis rs2637030 0.559 rs6881928 chr5:52988609 C/A cg06476337 chr5:52856530 NDUFS4 0.37 8.41 0.32 2.67e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.863 rs13149407 chr4:120437825 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.33 0.44 1.68e-31 Corneal astigmatism; BRCA cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg20701182 chr2:24300061 SF3B14 0.59 9.31 0.35 2.03e-19 Lymphocyte counts; BRCA cis rs778371 0.723 rs737027 chr2:233641083 G/C cg08000102 chr2:233561755 GIGYF2 0.85 21.22 0.64 5.01e-76 Schizophrenia; BRCA cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.07e-15 Developmental language disorder (linguistic errors); BRCA cis rs12220238 1.000 rs10824085 chr10:75911984 T/C cg19889307 chr10:75911429 ADK;AP3M1 0.49 7.87 0.3 1.56e-14 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg12311346 chr5:56204834 C5orf35 -0.8 -16.01 -0.54 9.43e-49 Initial pursuit acceleration; BRCA cis rs2404602 0.684 rs11072602 chr15:76873467 T/C cg23625390 chr15:77176239 SCAPER -0.55 -13.82 -0.48 3.23e-38 Blood metabolite levels; BRCA cis rs6545883 0.929 rs2256615 chr2:61679894 C/G cg15711740 chr2:61764176 XPO1 -0.53 -12.64 -0.45 7.37e-33 Tuberculosis; BRCA cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg18964960 chr10:1102726 WDR37 -0.52 -9.15 -0.34 7.48e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg11833968 chr6:79620685 NA -0.43 -9.5 -0.35 4e-20 Intelligence (multi-trait analysis); BRCA cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg26384229 chr12:38710491 ALG10B -0.56 -13.91 -0.48 1.23e-38 Morning vs. evening chronotype; BRCA cis rs950776 0.518 rs4886571 chr15:78833758 G/A cg06917634 chr15:78832804 PSMA4 -0.76 -17.64 -0.57 5.08e-57 Sudden cardiac arrest; BRCA cis rs218264 0.592 rs1396069 chr4:55369478 C/A cg17105814 chr4:55365203 NA -0.39 -8.17 -0.31 1.71e-15 Hemoglobin concentration;Hematocrit; BRCA cis rs7647973 0.626 rs9824435 chr3:49674343 A/G cg03060546 chr3:49711283 APEH -0.55 -8.39 -0.32 3.03e-16 Menarche (age at onset); BRCA cis rs6138458 0.961 rs11700073 chr20:24975215 C/G cg06937882 chr20:24974362 C20orf3 -0.47 -9.23 -0.34 3.82e-19 Blood protein levels; BRCA cis rs4594175 0.926 rs10873044 chr14:51615856 T/C cg23942311 chr14:51606299 NA 0.34 8.52 0.32 1.15e-16 Cancer; BRCA cis rs4285028 0.948 rs12488851 chr3:121687192 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.88 -0.4 2.15e-25 Multiple sclerosis; BRCA trans rs3780486 0.846 rs7873903 chr9:33142728 G/A cg20290983 chr6:43655470 MRPS18A 1.1 39.62 0.84 3.07e-174 IgG glycosylation; BRCA cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs1568889 0.838 rs7131379 chr11:28085789 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.46 0.63 6.26e-72 Bipolar disorder; BRCA cis rs7927771 0.800 rs55876153 chr11:47416636 G/A cg20307385 chr11:47447363 PSMC3 -0.43 -8.82 -0.33 1.08e-17 Subjective well-being; BRCA cis rs701145 0.585 rs1727879 chr3:153835819 C/T cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.89e-18 Coronary artery disease; BRCA cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.4 -0.35 9.53e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs208520 0.690 rs10455595 chr6:66738034 T/C cg07460842 chr6:66804631 NA 0.99 19.85 0.62 1.08e-68 Exhaled nitric oxide output; BRCA cis rs9658691 0.607 rs9658788 chr10:90776486 T/C cg03111039 chr10:90751583 FAS;ACTA2 -0.54 -7.93 -0.3 9.9e-15 Mosquito bite size; BRCA cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -8.74 -0.33 2.03e-17 Monocyte percentage of white cells; BRCA cis rs4970988 0.556 rs6695123 chr1:150563483 T/C cg17724175 chr1:150552817 MCL1 -0.33 -10.94 -0.4 1.14e-25 Urate levels; BRCA cis rs9381040 0.610 rs2235679 chr6:41020577 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -9.01 -0.34 2.4e-18 Alzheimer's disease (late onset); BRCA cis rs34779708 0.966 rs1545757 chr10:35445588 A/T cg03585969 chr10:35415529 CREM 0.57 11.66 0.42 1.32e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17092148 0.652 rs4911154 chr20:32996101 A/G cg16810054 chr20:33298113 TP53INP2 -0.42 -9.28 -0.34 2.68e-19 Neuroticism; BRCA cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.45 -0.41 9.57e-28 Schizophrenia; BRCA cis rs478304 0.934 rs517115 chr11:65526988 C/T cg08755490 chr11:65554678 OVOL1 0.55 11.5 0.41 5.88e-28 Acne (severe); BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg07262247 chr5:131593730 PDLIM4 0.36 8.58 0.32 7.25e-17 Acylcarnitine levels; BRCA cis rs7122539 0.506 rs11227625 chr11:66684151 T/G cg24851651 chr11:66362959 CCS 0.36 7.9 0.3 1.24e-14 HIV-1 susceptibility; BRCA cis rs12477438 0.539 rs720228 chr2:99704547 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.54 0.67 2.99e-83 Chronic sinus infection; BRCA cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg12310025 chr6:25882481 NA -0.61 -13.46 -0.47 1.6e-36 Intelligence (multi-trait analysis); BRCA cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg15083037 chr5:83017644 HAPLN1 0.44 9.61 0.36 1.68e-20 Prostate cancer; BRCA cis rs4727027 0.868 rs10952799 chr7:148840772 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.45 0.38 1.03e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9359856 0.510 rs6454775 chr6:90465000 A/T cg13799429 chr6:90582589 CASP8AP2 0.72 11.06 0.4 3.84e-26 Bipolar disorder; BRCA cis rs7524258 0.900 rs6577425 chr1:7306338 G/T cg07173049 chr1:7289937 CAMTA1 0.41 9.87 0.36 1.75e-21 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs7666738 0.830 rs28485415 chr4:99060340 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.92 0.4 1.43e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11252926 0.589 rs12359901 chr10:475068 A/G cg05528280 chr10:464225 DIP2C -0.38 -7.83 -0.3 2e-14 Psychosis in Alzheimer's disease; BRCA cis rs7582180 0.629 rs34745556 chr2:100942506 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA cis rs67478160 0.619 rs55824307 chr14:104271207 C/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.15 -0.4 1.74e-26 Schizophrenia; BRCA cis rs4891159 0.527 rs34956524 chr18:74130480 A/G cg24786174 chr18:74118243 ZNF516 0.83 25.27 0.71 3.13e-98 Longevity; BRCA cis rs9788721 0.836 rs72738718 chr15:78735438 G/C cg18825076 chr15:78729989 IREB2 -0.4 -8.34 -0.31 4.52e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.78 -0.53 1.24e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs62064224 0.589 rs8069673 chr17:30661250 C/T cg18200150 chr17:30822561 MYO1D -0.34 -8.53 -0.32 1.09e-16 Schizophrenia; BRCA cis rs9814567 0.929 rs9855013 chr3:134240414 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6138458 1.000 rs227651 chr20:24929834 A/G cg26195577 chr20:24973756 C20orf3 1.02 26.39 0.72 2.33e-104 Blood protein levels; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.61 12.59 0.45 1.22e-32 Lymphocyte counts; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg08067268 chr2:26466485 HADHB;HADHA -0.57 -10.18 -0.37 1.13e-22 Gut microbiome composition (summer); BRCA cis rs9462027 0.561 rs3798348 chr6:34771892 C/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 1.98e-14 Systemic lupus erythematosus; BRCA cis rs28735056 0.565 rs12957336 chr18:77716889 A/G cg05491587 chr18:77659695 KCNG2 0.33 8.39 0.32 3.05e-16 Schizophrenia; BRCA trans rs629535 0.821 rs680993 chr8:70050247 G/A cg21567404 chr3:27674614 NA 1.0 20.86 0.64 4.2e-74 Dupuytren's disease; BRCA cis rs7590368 1.000 rs7576898 chr2:10958956 A/G cg15705551 chr2:10952987 PDIA6 0.43 8.01 0.3 5.48e-15 Educational attainment (years of education); BRCA cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg20503657 chr10:835505 NA 1.04 18.15 0.58 1.14e-59 Eosinophil percentage of granulocytes; BRCA cis rs12497850 0.931 rs13315711 chr3:48986399 A/T cg07636037 chr3:49044803 WDR6 0.97 29.54 0.76 1.35e-121 Parkinson's disease; BRCA cis rs11190604 1.000 rs10883513 chr10:102316964 A/G cg07080220 chr10:102295463 HIF1AN 0.59 12.32 0.44 1.97e-31 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7592578 0.771 rs62181034 chr2:191354963 C/A cg10560079 chr2:191398806 TMEM194B -0.74 -13.43 -0.47 2.14e-36 Diastolic blood pressure; BRCA cis rs12618769 0.652 rs7588254 chr2:99217785 G/T cg10123293 chr2:99228465 UNC50 0.42 8.68 0.32 3.37e-17 Bipolar disorder; BRCA cis rs9814567 1.000 rs35718987 chr3:134272783 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10992471 0.603 rs13301537 chr9:95229047 A/G cg14631576 chr9:95140430 CENPP -0.38 -9.27 -0.34 2.93e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg12311346 chr5:56204834 C5orf35 0.57 11.49 0.41 6.82e-28 Initial pursuit acceleration; BRCA trans rs9291683 0.566 rs13122689 chr4:10044648 A/G cg26043149 chr18:55253948 FECH 0.4 8.71 0.33 2.66e-17 Bone mineral density; BRCA cis rs7945705 0.902 rs2016942 chr11:8938787 A/G cg12365402 chr11:9010492 NRIP3 0.43 9.51 0.35 3.75e-20 Hemoglobin concentration; BRCA cis rs7786808 0.707 rs11770299 chr7:158228822 G/A cg09998033 chr7:158218633 PTPRN2 -0.41 -9.6 -0.35 1.81e-20 Obesity-related traits; BRCA cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.4 11.25 0.41 6.76e-27 Monocyte percentage of white cells; BRCA cis rs7666738 0.688 rs4632667 chr4:98748299 A/G cg05340658 chr4:99064831 C4orf37 0.52 8.63 0.32 5.01e-17 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.704 rs798503 chr7:2789704 G/A cg13628971 chr7:2884303 GNA12 0.38 8.48 0.32 1.6e-16 Height; BRCA cis rs2153535 0.580 rs965706 chr6:8464708 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs11098499 0.866 rs10518329 chr4:120401835 A/G cg09307838 chr4:120376055 NA 0.66 14.32 0.49 1.48e-40 Corneal astigmatism; BRCA cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg19628046 chr18:33552617 C18orf21 0.63 13.0 0.46 1.88e-34 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.79 11.31 0.41 3.77e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs870825 0.616 rs6843185 chr4:185649878 A/C cg04058563 chr4:185651563 MLF1IP 0.79 17.87 0.58 3.04e-58 Blood protein levels; BRCA cis rs4780401 0.609 rs35649585 chr16:11813899 G/A cg01061890 chr16:11836724 TXNDC11 -0.55 -13.06 -0.46 9.81e-35 Rheumatoid arthritis; BRCA cis rs3857067 0.806 rs72665629 chr4:95112160 T/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs2816062 0.786 rs2745317 chr1:18896552 G/A cg18795169 chr1:18902165 NA -0.97 -29.66 -0.76 2.93e-122 Urate levels in lean individuals; BRCA cis rs7959452 0.590 rs11177619 chr12:69758871 G/A cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.79e-68 Blood protein levels; BRCA cis rs561341 1.000 rs542132 chr17:30307193 A/T cg00745463 chr17:30367425 LRRC37B -0.53 -8.87 -0.33 7.27e-18 Hip circumference adjusted for BMI; BRCA cis rs13046373 0.562 rs12627602 chr21:32022924 G/A cg22337977 chr21:31811175 KRTAP15-1 0.33 7.86 0.3 1.62e-14 HDL cholesterol; BRCA cis rs4268898 0.552 rs11125455 chr2:24374557 C/G cg06627628 chr2:24431161 ITSN2 0.41 8.57 0.32 8.03e-17 Asthma; BRCA cis rs4566357 0.615 rs3769642 chr2:227917323 T/C cg11843606 chr2:227700838 RHBDD1 -0.43 -9.65 -0.36 1.12e-20 Coronary artery disease; BRCA cis rs6570726 0.905 rs406799 chr6:145821837 G/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs2204008 0.837 rs11495548 chr12:38076756 C/T cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 7.99e-21 Bladder cancer; BRCA cis rs2921036 0.545 rs4840975 chr8:8363258 C/T cg06636001 chr8:8085503 FLJ10661 -0.48 -9.63 -0.36 1.35e-20 Neuroticism; BRCA cis rs13136331 0.532 rs1462367 chr4:88570528 T/C cg22416721 chr4:88570574 DMP1 0.62 15.02 0.51 7.04e-44 Sitting height ratio; BRCA cis rs853679 0.517 rs3757187 chr6:28107654 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.12 0.31 2.38e-15 Depression; BRCA cis rs921968 0.565 rs7595901 chr2:219606931 A/G cg02176678 chr2:219576539 TTLL4 -0.42 -11.2 -0.41 1.01e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg21280719 chr6:42927975 GNMT -0.33 -14.12 -0.49 1.34e-39 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7618915 0.547 rs7642198 chr3:52677960 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.45e-16 Bipolar disorder; BRCA cis rs4363385 0.747 rs2225919 chr1:152969603 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.14e-18 Inflammatory skin disease; BRCA cis rs3774749 0.565 rs2518796 chr3:50207075 A/G cg14019146 chr3:50243930 SLC38A3 -0.48 -11.57 -0.42 2.94e-28 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.611 rs2303289 chr2:24342242 C/G cg20701182 chr2:24300061 SF3B14 -0.71 -13.27 -0.46 1.16e-35 Lymphocyte counts; BRCA cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg07701084 chr6:150067640 NUP43 0.42 12.23 0.44 4.68e-31 Lung cancer; BRCA cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg19454999 chr17:41278357 BRCA1;NBR2 -0.52 -11.46 -0.41 9.22e-28 Menopause (age at onset); BRCA cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -12.11 -0.43 1.56e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 9.13 0.34 9.05e-19 Multiple sclerosis; BRCA cis rs9560113 1.000 rs9555811 chr13:112181532 A/C cg10483660 chr13:112241077 NA 0.32 7.97 0.3 7.17e-15 Menarche (age at onset); BRCA cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg02187348 chr16:89574699 SPG7 0.39 9.12 0.34 9.46e-19 Multiple myeloma (IgH translocation); BRCA cis rs61990749 0.597 rs4632066 chr14:78247282 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.59 -9.56 -0.35 2.59e-20 Fibroblast growth factor basic levels; BRCA trans rs800082 0.698 rs800074 chr3:144347638 A/G cg24215973 chr2:240111563 HDAC4 -0.6 -14.58 -0.5 8.91e-42 Smoking behavior; BRCA cis rs6723226 0.503 rs4952262 chr2:32597234 G/A cg02381751 chr2:32503542 YIPF4 -0.45 -9.32 -0.35 1.9e-19 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.11 -0.46 6.06e-35 Platelet count; BRCA trans rs6089829 0.962 rs4586690 chr20:61658595 G/T cg23505145 chr19:12996616 KLF1 0.56 12.63 0.45 8.41e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs6952808 0.689 rs871924 chr7:2047845 A/G cg21782813 chr7:2030301 MAD1L1 0.38 11.25 0.41 6.78e-27 Bipolar disorder and schizophrenia; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg26608667 chr7:1196370 ZFAND2A 0.44 10.3 0.38 3.93e-23 Longevity;Endometriosis; BRCA cis rs7677751 0.767 rs890205 chr4:55063373 C/A cg17187183 chr4:55093834 PDGFRA 0.4 8.27 0.31 7.82e-16 Corneal astigmatism; BRCA cis rs2075371 0.933 rs1833475 chr7:133958263 C/T cg02659138 chr7:134003124 SLC35B4 0.32 9.78 0.36 3.74e-21 Mean platelet volume; BRCA cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg03517284 chr6:25882590 NA -0.51 -11.55 -0.42 3.53e-28 Blood metabolite levels; BRCA cis rs4141404 0.737 rs5998058 chr22:32006408 C/T cg02404636 chr22:31891804 SFI1 0.42 8.85 0.33 8.46e-18 Paclitaxel-induced neuropathy; BRCA trans rs2204008 0.805 rs7296063 chr12:37964775 T/G cg06521331 chr12:34319734 NA -0.54 -9.72 -0.36 6.44e-21 Bladder cancer; BRCA trans rs6582630 0.519 rs11495699 chr12:38286219 G/T cg06521331 chr12:34319734 NA -0.5 -8.98 -0.33 3.01e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs2576037 0.526 rs1893427 chr18:44434987 C/T cg19077165 chr18:44547161 KATNAL2 -0.53 -11.45 -0.41 1e-27 Personality dimensions; BRCA cis rs10791323 0.569 rs2257004 chr11:133712473 C/T cg06766960 chr11:133703094 NA -0.61 -12.96 -0.46 2.89e-34 Childhood ear infection; BRCA trans rs7395662 0.926 rs11039893 chr11:48657754 G/A cg00717180 chr2:96193071 NA -0.31 -8.61 -0.32 5.57e-17 HDL cholesterol; BRCA trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg03929089 chr4:120376271 NA -0.55 -11.06 -0.4 3.8e-26 Coronary artery disease; BRCA cis rs7586879 0.828 rs10184813 chr2:25090236 T/C cg04586622 chr2:25135609 ADCY3 0.38 9.09 0.34 1.19e-18 Body mass index; BRCA cis rs7666738 0.753 rs35194639 chr4:99053819 G/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1499972 0.887 rs73168397 chr3:117657197 C/T cg07612923 chr3:117604196 NA 0.6 8.11 0.31 2.61e-15 Schizophrenia; BRCA cis rs365132 0.875 rs353495 chr5:176430723 T/C cg16309518 chr5:176445507 NA -0.4 -9.72 -0.36 6.35e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7582720 0.511 rs116219813 chr2:204081675 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.8 12.22 0.44 5.05e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg04013093 chr6:42928303 GNMT -0.29 -8.82 -0.33 1.12e-17 Plasma homocysteine levels (post-methionine load test); BRCA cis rs17270561 0.609 rs4711093 chr6:25687895 T/C cg16482183 chr6:26056742 HIST1H1C 0.43 8.15 0.31 1.98e-15 Iron status biomarkers; BRCA cis rs965469 0.744 rs6139093 chr20:3334838 A/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.77 -0.33 1.66e-17 IFN-related cytopenia; BRCA cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.41e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs586533 0.846 rs619391 chr11:99498525 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA trans rs9291683 0.530 rs6449196 chr4:9973660 C/T cg26043149 chr18:55253948 FECH -0.4 -8.86 -0.33 8.01e-18 Bone mineral density; BRCA cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg02187348 chr16:89574699 SPG7 -0.37 -8.47 -0.32 1.73e-16 Multiple myeloma (IgH translocation); BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg16145915 chr7:1198662 ZFAND2A -0.69 -17.97 -0.58 1.01e-58 Longevity;Endometriosis; BRCA cis rs3008870 1.000 rs2985794 chr1:67425311 T/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.58 0.67 1.81e-83 Lymphocyte percentage of white cells; BRCA cis rs6840360 0.571 rs11729136 chr4:152529227 C/A cg22705602 chr4:152727874 NA -0.33 -8.22 -0.31 1.1e-15 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.599 rs77878465 chr7:106890996 G/A cg02696742 chr7:106810147 HBP1 -0.47 -8.34 -0.31 4.72e-16 Coronary artery disease; BRCA cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.64 -0.32 4.41e-17 Electroencephalogram traits; BRCA cis rs11098499 0.874 rs13123591 chr4:120105990 T/G cg09307838 chr4:120376055 NA 0.6 11.17 0.4 1.44e-26 Corneal astigmatism; BRCA cis rs12497850 0.931 rs9846123 chr3:49088112 C/T cg07636037 chr3:49044803 WDR6 -0.99 -29.98 -0.76 6.1e-124 Parkinson's disease; BRCA cis rs1865760 0.519 rs4360119 chr6:25815074 C/G cg16482183 chr6:26056742 HIST1H1C 0.53 10.31 0.38 3.75e-23 Height; BRCA cis rs11098499 0.863 rs10019674 chr4:120443489 C/T cg09307838 chr4:120376055 NA -0.65 -12.73 -0.45 2.94e-33 Corneal astigmatism; BRCA cis rs698813 0.763 rs1067335 chr2:44625958 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.25 0.34 3.25e-19 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg23285459 chr7:2802560 GNA12 -0.32 -8.18 -0.31 1.5e-15 Height; BRCA cis rs780096 0.506 rs1262430 chr2:27673798 T/C cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.87 -0.33 7.09e-18 Total body bone mineral density; BRCA cis rs9649213 0.593 rs6949718 chr7:97924483 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.55 0.44 1.93e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs17401966 0.838 rs11580854 chr1:10293565 G/A cg03954927 chr1:10346856 KIF1B 0.42 13.26 0.46 1.29e-35 Hepatocellular carcinoma; BRCA cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg01819863 chr10:32635814 EPC1 1.21 20.81 0.64 8.38e-74 Sexual dysfunction (female); BRCA cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg04166393 chr7:2884313 GNA12 0.48 9.82 0.36 2.81e-21 Height; BRCA cis rs10752881 1.000 rs4304541 chr1:182970238 G/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.73 0.55 2.12e-52 Colorectal cancer; BRCA cis rs7617773 0.815 rs9825637 chr3:48372282 T/C cg11946769 chr3:48343235 NME6 0.63 13.3 0.47 8.36e-36 Coronary artery disease; BRCA cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.43 0.35 7.76e-20 Tonsillectomy; BRCA cis rs10927875 0.929 rs4661674 chr1:16296039 A/G cg21385522 chr1:16154831 NA -0.6 -11.25 -0.41 6.55e-27 Dilated cardiomyopathy; BRCA cis rs8114671 0.647 rs945959 chr20:33734905 G/C cg07148914 chr20:33460835 GGT7 0.35 7.98 0.3 6.93e-15 Height; BRCA cis rs6460942 0.915 rs7802454 chr7:12454508 A/G cg20607287 chr7:12443886 VWDE -0.58 -8.36 -0.31 4.04e-16 Coronary artery disease; BRCA cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.43 -0.32 2.33e-16 Colorectal cancer; BRCA cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.69 -0.53 3.55e-47 Chronic sinus infection; BRCA cis rs798554 0.686 rs2527690 chr7:2854250 C/T cg09658497 chr7:2847517 GNA12 -0.41 -8.58 -0.32 7.35e-17 Height; BRCA cis rs2204008 0.805 rs3863360 chr12:37966432 C/T cg13010199 chr12:38710504 ALG10B 0.41 8.37 0.31 3.72e-16 Bladder cancer; BRCA cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg20891283 chr12:69753455 YEATS4 0.73 21.96 0.66 4.86e-80 Blood protein levels; BRCA cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg11764359 chr7:65958608 NA 0.67 15.04 0.51 5.33e-44 Aortic root size; BRCA cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg11941060 chr3:133502564 NA -0.6 -14.42 -0.5 4.95e-41 Iron status biomarkers; BRCA cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.91 0.4 1.58e-25 Cognitive ability; BRCA cis rs1707322 1.000 rs4074225 chr1:46392364 G/C cg06784218 chr1:46089804 CCDC17 0.49 11.66 0.42 1.34e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg08917208 chr2:24149416 ATAD2B 1.06 14.39 0.49 7.51e-41 Lymphocyte counts; BRCA cis rs4074536 0.574 rs10923353 chr1:116290727 G/A cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs3733585 0.699 rs6449157 chr4:9960442 G/A cg00071950 chr4:10020882 SLC2A9 -0.47 -11.19 -0.4 1.16e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13082711 0.522 rs569960 chr3:27329540 C/T cg02860705 chr3:27208620 NA 0.42 8.83 0.33 1.01e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs10782582 0.609 rs1628063 chr1:76391646 A/G cg03433033 chr1:76189801 ACADM -0.4 -8.46 -0.32 1.79e-16 Daytime sleep phenotypes; BRCA cis rs7523050 0.730 rs12729728 chr1:109431110 C/A cg08274380 chr1:109419600 GPSM2 1.19 15.71 0.53 2.82e-47 Fat distribution (HIV); BRCA cis rs514406 0.547 rs377808 chr1:53190359 T/G cg16325326 chr1:53192061 ZYG11B 0.96 26.73 0.73 2.94e-106 Monocyte count; BRCA cis rs858239 0.896 rs1637192 chr7:23260514 G/A cg23682824 chr7:23144976 KLHL7 0.34 8.88 0.33 6.69e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.24e-18 Tonsillectomy; BRCA cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.62 0.39 2.29e-24 Motion sickness; BRCA cis rs6089584 0.816 rs6061410 chr20:60625329 A/G cg06108461 chr20:60628389 TAF4 -1.01 -22.74 -0.67 2.4e-84 Body mass index; BRCA cis rs3772130 1.000 rs3772130 chr3:121344140 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.67 0.36 1.02e-20 Cognitive performance; BRCA cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg11657440 chr19:46296263 DMWD -0.54 -12.72 -0.45 3.2e-33 Coronary artery disease; BRCA cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg16414030 chr3:133502952 NA -0.47 -11.12 -0.4 2.32e-26 Iron status biomarkers; BRCA cis rs7312933 0.703 rs7957471 chr12:42545591 G/T cg01256987 chr12:42539512 GXYLT1 -0.45 -9.11 -0.34 1.02e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs933688 1.000 rs12654787 chr5:90713259 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.87 18.79 0.6 4.58e-63 Smoking behavior; BRCA cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg27478167 chr7:817139 HEATR2 -0.57 -11.49 -0.41 6.87e-28 Cerebrospinal P-tau181p levels; BRCA cis rs6088590 1.000 rs2295353 chr20:33356511 C/T cg06115741 chr20:33292138 TP53INP2 0.51 11.53 0.42 4.35e-28 Coronary artery disease; BRCA trans rs4332037 0.664 rs73046334 chr7:1887037 T/C cg25206134 chr2:45395956 NA 0.53 8.76 0.33 1.76e-17 Bipolar disorder; BRCA cis rs17688601 1.000 rs17688583 chr7:40865696 C/T cg05119115 chr7:40866195 C7orf10 -0.6 -11.65 -0.42 1.45e-28 Pancreatic cancer; BRCA cis rs6842047 0.901 rs2102575 chr4:187131504 G/A cg23442198 chr4:187126114 CYP4V2 0.92 10.79 0.39 4.94e-25 Blood protein levels; BRCA cis rs7923452 0.507 rs215494 chr10:30776589 T/G cg18806716 chr10:30721971 MAP3K8 -0.41 -9.61 -0.36 1.6e-20 Itch intensity from mosquito bite; BRCA cis rs877529 0.967 rs139405 chr22:39549526 C/A cg12193277 chr22:39547181 CBX7 0.46 12.33 0.44 1.8e-31 Multiple myeloma; BRCA cis rs2404602 0.647 rs35940181 chr15:77180019 G/A cg23625390 chr15:77176239 SCAPER -0.54 -13.62 -0.47 2.72e-37 Blood metabolite levels; BRCA cis rs877282 0.947 rs4133015 chr10:774131 T/C cg17470449 chr10:769945 NA 0.5 9.55 0.35 2.74e-20 Uric acid levels; BRCA cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg08999081 chr20:33150536 PIGU -0.45 -12.16 -0.43 9.91e-31 Glomerular filtration rate (creatinine); BRCA trans rs3010562 1.000 rs3010562 chr6:167765251 A/G cg13033054 chr21:33948561 TCP10L 0.34 8.31 0.31 5.71e-16 Gut microbiome composition (summer and winter); BRCA cis rs921968 0.643 rs590771 chr2:219369851 C/T cg02176678 chr2:219576539 TTLL4 0.39 10.31 0.38 3.65e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs739401 0.572 rs410820 chr11:3080102 G/A cg25174290 chr11:3078921 CARS 0.44 13.28 0.47 1.01e-35 Longevity; BRCA cis rs12142240 0.698 rs68191463 chr1:46808695 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs9311474 0.713 rs181274 chr3:52233861 T/A cg15698299 chr3:52233019 ALAS1 -0.4 -9.46 -0.35 6.03e-20 Electroencephalogram traits; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg15112475 chr7:1198522 ZFAND2A 0.4 8.66 0.32 3.86e-17 Longevity;Endometriosis; BRCA cis rs7552404 0.727 rs5745390 chr1:76306591 A/C cg22875332 chr1:76189707 ACADM 0.64 12.06 0.43 2.44e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg02734326 chr4:10020555 SLC2A9 0.37 8.37 0.31 3.66e-16 Bone mineral density; BRCA trans rs7618501 0.633 rs9814664 chr3:50078541 C/T cg21659725 chr3:3221576 CRBN -0.47 -12.07 -0.43 2.42e-30 Intelligence (multi-trait analysis); BRCA cis rs7586879 0.789 rs67221599 chr2:25131948 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.52 0.35 3.59e-20 Body mass index; BRCA cis rs4555082 0.874 rs2816612 chr14:105723103 C/T cg27165867 chr14:105738592 BRF1 -0.35 -8.31 -0.31 5.74e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs1865721 0.771 rs6566092 chr18:73136496 C/T cg26385618 chr18:73139727 C18orf62 -0.43 -10.64 -0.39 1.88e-24 Intelligence; BRCA cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.64 -0.42 1.5e-28 Alcohol dependence; BRCA trans rs1997103 1.000 rs10270618 chr7:55396712 T/A cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7617773 0.780 rs4392440 chr3:48343920 C/T cg11946769 chr3:48343235 NME6 0.69 13.87 0.48 2.01e-38 Coronary artery disease; BRCA cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg22875332 chr1:76189707 ACADM 0.7 14.98 0.51 1.07e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7772486 0.754 rs4896832 chr6:145964151 G/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.45 -0.35 6.3e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs6496044 0.547 rs1564719 chr15:86054266 C/T cg10818794 chr15:86012489 AKAP13 -0.32 -8.68 -0.32 3.24e-17 Interstitial lung disease; BRCA cis rs4908768 0.539 rs6675443 chr1:8651582 T/A cg20416874 chr1:8611966 RERE -0.3 -8.34 -0.31 4.48e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg26769984 chr7:1090371 C7orf50 0.48 9.14 0.34 7.88e-19 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg17366294 chr4:99064904 C4orf37 0.41 9.74 0.36 5.54e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs6815814 0.950 rs5743593 chr4:38802913 A/G cg06935464 chr4:38784597 TLR10 0.51 8.52 0.32 1.18e-16 Breast cancer; BRCA trans rs1005277 0.522 rs289647 chr10:37968278 A/G cg17830980 chr10:43048298 ZNF37B -0.4 -9.31 -0.35 2.06e-19 Extrinsic epigenetic age acceleration; BRCA cis rs2455601 0.882 rs11042106 chr11:8896083 C/T cg21881798 chr11:8931708 C11orf17;ST5 0.48 8.09 0.3 2.99e-15 Schizophrenia; BRCA trans rs853679 0.607 rs34396849 chr6:28250955 A/C cg06606381 chr12:133084897 FBRSL1 -0.78 -8.32 -0.31 5.37e-16 Depression; BRCA trans rs61931739 0.500 rs7306334 chr12:34482900 A/G cg26384229 chr12:38710491 ALG10B -0.72 -16.32 -0.54 2.63e-50 Morning vs. evening chronotype; BRCA cis rs4664304 0.620 rs10929956 chr2:160714615 C/T cg01092293 chr2:160761427 LY75 0.36 8.53 0.32 1.05e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9814567 0.793 rs55940445 chr3:134306064 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 8.73 0.33 2.21e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4363385 0.720 rs6704498 chr1:152964740 C/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.51 -0.35 3.76e-20 Inflammatory skin disease; BRCA cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg24692254 chr21:30365293 RNF160 -0.6 -15.25 -0.52 4.97e-45 Dental caries; BRCA cis rs11711311 1.000 rs9826808 chr3:113455644 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs6089829 0.889 rs6062773 chr20:61663262 G/C cg08564027 chr20:61660810 NA 0.85 22.93 0.67 2.35e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs2980439 0.525 rs2980508 chr8:8171732 C/T cg11608241 chr8:8085544 FLJ10661 0.27 7.86 0.3 1.64e-14 Neuroticism; BRCA cis rs875971 0.929 rs12535036 chr7:65964063 G/T cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs3793683 1.000 rs3793683 chr10:134568387 G/T cg18305652 chr10:134549665 INPP5A -0.3 -8.63 -0.32 4.76e-17 Migraine; BRCA cis rs10504073 0.584 rs62507177 chr8:49937306 C/A cg00325661 chr8:49890786 NA 0.47 13.48 0.47 1.31e-36 Blood metabolite ratios; BRCA cis rs10089 0.552 rs1351141 chr5:127550055 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.5 -10.25 -0.38 6.39e-23 Ileal carcinoids; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg00149659 chr3:10157352 C3orf10 0.8 13.88 0.48 1.79e-38 Alzheimer's disease; BRCA trans rs2204008 0.720 rs11180923 chr12:38255172 A/T cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Bladder cancer; BRCA cis rs2204008 0.837 rs11180821 chr12:38242843 A/G cg26384229 chr12:38710491 ALG10B 0.66 15.04 0.51 5.67e-44 Bladder cancer; BRCA cis rs4664304 0.620 rs2048436 chr2:160712119 A/G cg18514922 chr2:160761262 LY75 0.34 7.97 0.3 7.22e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs13064411 0.696 rs6783965 chr3:113198722 C/T cg18753928 chr3:113234510 CCDC52 -0.58 -11.7 -0.42 8.4e-29 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2153535 0.580 rs1577466 chr6:8444192 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.12e-23 Motion sickness; BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg08219700 chr8:58056026 NA 0.59 9.48 0.35 4.84e-20 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.93 0.3 1.01e-14 Corneal astigmatism; BRCA cis rs7267979 1.000 rs2500443 chr20:25331442 C/T cg08601574 chr20:25228251 PYGB -0.38 -9.16 -0.34 7.22e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.99 -0.3 6.42e-15 Total body bone mineral density; BRCA cis rs6120849 0.901 rs6058194 chr20:33739831 G/A cg24642439 chr20:33292090 TP53INP2 0.49 8.71 0.33 2.63e-17 Protein C levels; BRCA cis rs875971 0.862 rs9791712 chr7:66105163 C/G cg11764359 chr7:65958608 NA -0.7 -15.03 -0.51 5.83e-44 Aortic root size; BRCA cis rs7618501 0.602 rs34831713 chr3:50118748 T/C cg05623727 chr3:50126028 RBM5 -0.44 -10.38 -0.38 2e-23 Intelligence (multi-trait analysis); BRCA cis rs4930103 0.619 rs739905 chr11:1980360 G/C cg23202291 chr11:1979235 NA 0.41 9.23 0.34 3.93e-19 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs2625529 0.652 rs1481862 chr15:72245648 G/A cg16672083 chr15:72433130 SENP8 0.64 15.37 0.52 1.38e-45 Red blood cell count; BRCA cis rs7944584 0.632 rs749067 chr11:47318157 T/C cg20307385 chr11:47447363 PSMC3 0.58 11.69 0.42 9.24e-29 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs523522 0.962 rs55848094 chr12:120966659 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.5e-36 High light scatter reticulocyte count; BRCA cis rs875971 0.830 rs1167406 chr7:65556936 G/C cg11764359 chr7:65958608 NA -0.74 -16.09 -0.54 3.77e-49 Aortic root size; BRCA cis rs34172651 0.917 rs2343606 chr16:24793741 C/T cg04756594 chr16:24857601 SLC5A11 0.34 8.31 0.31 5.84e-16 Intelligence (multi-trait analysis); BRCA cis rs9296092 0.560 rs9469505 chr6:33527348 A/G cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs6912958 0.515 rs381782 chr6:88040649 C/T cg04972856 chr6:88032051 C6orf162;GJB7 0.31 8.02 0.3 4.98e-15 Monocyte percentage of white cells; BRCA cis rs13256369 1.000 rs10110591 chr8:8576608 G/T cg06671706 chr8:8559999 CLDN23 -0.4 -8.04 -0.3 4.37e-15 Obesity-related traits; BRCA cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg20476274 chr7:133979776 SLC35B4 0.65 19.4 0.61 2.78e-66 Mean platelet volume; BRCA cis rs2108225 0.872 rs2051955 chr7:107441154 C/T cg18560240 chr7:107437656 SLC26A3 -0.55 -11.52 -0.41 4.83e-28 Ulcerative colitis; BRCA cis rs6604026 0.740 rs10782945 chr1:93304272 C/T cg17283838 chr1:93427260 FAM69A -0.4 -8.3 -0.31 6.15e-16 Multiple sclerosis; BRCA cis rs933688 1.000 rs985434 chr5:90744509 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.65 0.61 1.3e-67 Smoking behavior; BRCA cis rs344364 0.511 rs1742469 chr16:1950244 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.56 -9.78 -0.36 3.77e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg00484396 chr16:3507460 NAT15 0.46 9.99 0.37 6.34e-22 Tuberculosis; BRCA cis rs9859260 0.710 rs366268 chr3:195782177 A/G cg12923728 chr3:195709715 SDHAP1 0.38 7.85 0.3 1.72e-14 Mean corpuscular volume; BRCA cis rs2115630 1.000 rs10220733 chr15:85280864 G/A cg11189052 chr15:85197271 WDR73 -0.33 -7.98 -0.3 6.92e-15 P wave terminal force; BRCA trans rs1005277 0.579 rs1780137 chr10:38501475 C/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.24 -0.46 1.63e-35 Extrinsic epigenetic age acceleration; BRCA cis rs12586317 0.620 rs58320987 chr14:35587726 T/C cg16230307 chr14:35515116 FAM177A1 0.7 14.69 0.5 2.74e-42 Psoriasis; BRCA cis rs3820928 0.605 rs7560867 chr2:227780945 C/A cg05526886 chr2:227700861 RHBDD1 -0.44 -9.23 -0.34 4.04e-19 Pulmonary function; BRCA cis rs2075371 0.966 rs1901204 chr7:133985896 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.58 0.39 3.38e-24 Mean platelet volume; BRCA trans rs2749592 0.513 rs1208708 chr10:38085576 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.06 -0.3 3.65e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs2204008 0.774 rs11180977 chr12:38263094 G/T cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs10504229 0.683 rs16921807 chr8:58105967 C/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg09436375 chr6:42928200 GNMT -0.3 -11.24 -0.41 6.95e-27 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg03709012 chr19:19516395 GATAD2A -0.75 -17.01 -0.56 8.07e-54 Tonsillectomy; BRCA cis rs1371614 0.611 rs877272 chr2:27139888 C/T cg12368169 chr2:27073192 DPYSL5 0.3 9.0 0.34 2.53e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs875971 0.825 rs66981195 chr7:66079035 C/A cg11764359 chr7:65958608 NA -0.75 -16.53 -0.55 2.26e-51 Aortic root size; BRCA cis rs9814567 0.806 rs11927539 chr3:134319448 C/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7617773 0.817 rs9834095 chr3:48327751 G/A cg11946769 chr3:48343235 NME6 0.63 13.47 0.47 1.45e-36 Coronary artery disease; BRCA trans rs10242455 0.702 rs73403247 chr7:99088730 G/A cg09045935 chr12:6379348 NA 0.88 8.55 0.32 8.86e-17 Blood metabolite levels; BRCA cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg12143784 chr7:64541923 NA 0.38 8.09 0.3 3.08e-15 Calcium levels; BRCA cis rs765787 0.530 rs28897155 chr15:45533974 T/C cg24006582 chr15:45444508 DUOX1 -0.54 -11.07 -0.4 3.42e-26 Uric acid levels; BRCA cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg12310025 chr6:25882481 NA -0.76 -17.94 -0.58 1.31e-58 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.966 rs12774834 chr10:35400070 A/T cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.98e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs911555 0.692 rs60235428 chr14:103904350 T/C cg12935359 chr14:103987150 CKB 0.64 15.01 0.51 8.04e-44 Intelligence (multi-trait analysis); BRCA cis rs6701037 0.566 rs4344281 chr1:175135376 C/T cg17845761 chr1:175162550 KIAA0040 0.25 9.71 0.36 6.88e-21 Alcohol dependence; BRCA cis rs9457247 0.663 rs12526548 chr6:167431147 C/T cg23791538 chr6:167370224 RNASET2 -0.33 -7.97 -0.3 7.1e-15 Crohn's disease; BRCA cis rs7100689 0.516 rs10788546 chr10:82034854 T/C cg01528321 chr10:82214614 TSPAN14 0.74 15.74 0.53 1.94e-47 Post bronchodilator FEV1; BRCA cis rs11098499 0.657 rs4463052 chr4:120313258 T/C cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18301423 chr5:131593218 PDLIM4 0.33 8.02 0.3 5.23e-15 Acylcarnitine levels; BRCA cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg24549020 chr5:56110836 MAP3K1 0.66 13.4 0.47 2.87e-36 Initial pursuit acceleration; BRCA cis rs453301 0.686 rs13252797 chr8:8861430 A/G cg08975724 chr8:8085496 FLJ10661 0.36 7.81 0.3 2.43e-14 Joint mobility (Beighton score); BRCA trans rs61931739 0.534 rs2220547 chr12:34106255 G/A cg26384229 chr12:38710491 ALG10B 0.65 13.67 0.48 1.64e-37 Morning vs. evening chronotype; BRCA trans rs61931739 0.517 rs11612493 chr12:34114272 A/C cg26384229 chr12:38710491 ALG10B 0.63 13.71 0.48 1.11e-37 Morning vs. evening chronotype; BRCA cis rs4363385 0.654 rs1129654 chr1:152958238 A/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.79 -0.33 1.41e-17 Inflammatory skin disease; BRCA cis rs6430585 0.528 rs16832417 chr2:136744678 C/T cg07169764 chr2:136633963 MCM6 1.22 23.88 0.69 1.37e-90 Corneal structure; BRCA cis rs13395090 1.000 rs11687349 chr2:3717496 A/C cg19052272 chr2:3704530 ALLC -0.32 -7.97 -0.3 7.33e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs7552404 0.883 rs11161493 chr1:76206254 T/A cg03433033 chr1:76189801 ACADM 0.89 23.73 0.68 9.91e-90 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4862307 0.836 rs4507404 chr4:185003767 C/T cg06737308 chr4:185021514 ENPP6 -0.37 -8.17 -0.31 1.7e-15 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs7640424 0.716 rs35703078 chr3:107859558 A/G cg09227934 chr3:107805635 CD47 -0.43 -8.91 -0.33 5.36e-18 Body mass index; BRCA cis rs9644630 0.696 rs13261824 chr8:19313912 C/G cg06562184 chr8:19319451 CSGALNACT1 0.34 8.06 0.3 3.85e-15 Oropharynx cancer; BRCA cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg22972055 chr7:872293 UNC84A 0.39 8.69 0.32 3.12e-17 Cerebrospinal P-tau181p levels; BRCA cis rs7945718 0.967 rs10765990 chr11:12769444 G/A cg25843174 chr11:12811716 TEAD1 0.23 8.75 0.33 1.88e-17 Educational attainment (years of education); BRCA cis rs11098499 0.865 rs4001305 chr4:120359236 G/T cg09307838 chr4:120376055 NA 0.76 16.73 0.55 2.21e-52 Corneal astigmatism; BRCA cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg12011299 chr4:100065546 ADH4 0.5 11.51 0.41 5.61e-28 Alcohol dependence; BRCA cis rs113835537 0.529 rs2305532 chr11:66298594 C/T cg24851651 chr11:66362959 CCS 0.48 8.72 0.33 2.46e-17 Airway imaging phenotypes; BRCA cis rs4718428 1.000 rs1830070 chr7:66349671 T/C cg18252515 chr7:66147081 NA -0.41 -8.77 -0.33 1.61e-17 Corneal structure; BRCA trans rs11098499 0.908 rs7695996 chr4:120322033 C/T cg25214090 chr10:38739885 LOC399744 0.54 12.24 0.44 4.06e-31 Corneal astigmatism; BRCA cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg06671706 chr8:8559999 CLDN23 -0.41 -8.21 -0.31 1.24e-15 Obesity-related traits; BRCA cis rs752010 0.714 rs6664708 chr1:42083070 G/A cg06885757 chr1:42089581 HIVEP3 0.28 10.43 0.38 1.21e-23 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2652834 1.000 rs8032104 chr15:63400584 A/G cg05507819 chr15:63340323 TPM1 0.45 8.03 0.3 4.77e-15 HDL cholesterol; BRCA cis rs7666738 0.888 rs13110683 chr4:98983368 G/C cg17366294 chr4:99064904 C4orf37 0.54 11.58 0.42 2.76e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs72634258 0.554 rs4908704 chr1:7918904 A/G cg00042356 chr1:8021962 PARK7 0.54 8.59 0.32 6.85e-17 Inflammatory bowel disease; BRCA cis rs11051970 0.611 rs10844197 chr12:32561015 A/C cg24626660 chr12:32551988 NA 0.31 9.18 0.34 6.02e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs796364 1.000 rs11895190 chr2:200838613 A/G cg23649088 chr2:200775458 C2orf69 -0.58 -8.55 -0.32 9.01e-17 Schizophrenia; BRCA cis rs2279817 1.000 rs35148872 chr1:18020184 G/A cg21791023 chr1:18019539 ARHGEF10L -0.53 -13.44 -0.47 1.98e-36 Neuroticism; BRCA cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.97 0.33 3.36e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1005277 0.579 rs2474608 chr10:38457109 C/T cg00409905 chr10:38381863 ZNF37A -0.51 -10.9 -0.4 1.69e-25 Extrinsic epigenetic age acceleration; BRCA cis rs2239547 0.603 rs59989280 chr3:53098875 T/C cg11645453 chr3:52864694 ITIH4 0.39 9.18 0.34 5.99e-19 Schizophrenia; BRCA cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 14.21 0.49 5.27e-40 Electrocardiographic conduction measures; BRCA cis rs7756236 0.521 rs9470363 chr6:36624713 G/A cg08179530 chr6:36648295 CDKN1A 0.38 8.25 0.31 9.2e-16 QRS duration; BRCA trans rs61931739 0.929 rs3912551 chr12:34076696 C/T cg26384229 chr12:38710491 ALG10B -0.43 -10.3 -0.38 3.98e-23 Morning vs. evening chronotype; BRCA cis rs4820294 1.000 rs739139 chr22:38067011 C/G cg21798802 chr22:38057573 PDXP 0.49 13.18 0.46 2.91e-35 Fat distribution (HIV); BRCA cis rs12586317 0.620 rs17091786 chr14:35565856 A/T cg05294307 chr14:35346193 BAZ1A -0.61 -10.41 -0.38 1.57e-23 Psoriasis; BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg04944784 chr2:26401820 FAM59B -0.82 -14.79 -0.5 8.78e-43 Gut microbiome composition (summer); BRCA cis rs17601876 0.814 rs8042086 chr15:51561478 C/T cg19946085 chr15:51559439 CYP19A1 -0.39 -11.62 -0.42 1.87e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg10932868 chr11:921992 NA 0.51 13.27 0.46 1.17e-35 Alzheimer's disease (late onset); BRCA cis rs4074536 0.574 rs10754350 chr1:116291885 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.66 -0.32 3.83e-17 QRS duration; BRCA cis rs875971 0.660 rs801193 chr7:66030612 A/C cg11764359 chr7:65958608 NA -0.69 -15.53 -0.52 2.29e-46 Aortic root size; BRCA cis rs10504229 1.000 rs66886949 chr8:58187613 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs7945705 0.692 rs11042149 chr11:9010737 T/C cg12365402 chr11:9010492 NRIP3 -0.4 -9.33 -0.35 1.68e-19 Hemoglobin concentration; BRCA cis rs9503598 0.636 rs6596975 chr6:3465925 G/A cg00476032 chr6:3446245 SLC22A23 0.38 9.27 0.34 2.73e-19 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs11190604 1.000 rs2489039 chr10:102328036 T/A cg07080220 chr10:102295463 HIF1AN 0.57 13.04 0.46 1.19e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs61931739 0.500 rs11053272 chr12:34547020 C/G cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs10751667 0.643 rs10751666 chr11:941933 C/T cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs11690935 0.959 rs4667694 chr2:172605399 G/A cg13550731 chr2:172543902 DYNC1I2 -0.9 -28.32 -0.75 5.92e-115 Schizophrenia; BRCA trans rs11577318 0.853 rs12728971 chr1:26626612 C/T cg07461501 chr17:79650226 HGS;ARL16 0.39 10.0 0.37 5.83e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs7647973 0.626 rs1996663 chr3:49878264 C/G cg07636037 chr3:49044803 WDR6 -0.53 -8.74 -0.33 2.06e-17 Menarche (age at onset); BRCA cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg23711669 chr6:146136114 FBXO30 0.77 18.22 0.58 4.85e-60 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg04944784 chr2:26401820 FAM59B 0.73 11.88 0.43 1.47e-29 Gut microbiome composition (summer); BRCA cis rs4664304 0.620 rs2048436 chr2:160712119 A/G cg02280532 chr2:160761244 LY75 0.35 7.85 0.3 1.81e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2404602 1.000 rs6495206 chr15:76870963 C/T cg23625390 chr15:77176239 SCAPER 0.39 9.61 0.36 1.64e-20 Blood metabolite levels; BRCA cis rs11577318 0.853 rs11803933 chr1:26629465 G/C cg04990556 chr1:26633338 UBXN11 -0.47 -9.32 -0.35 1.84e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs6430585 0.941 rs60963894 chr2:136539670 T/G cg07169764 chr2:136633963 MCM6 1.0 20.29 0.63 4.98e-71 Corneal structure; BRCA cis rs61008539 0.893 rs4719460 chr7:859610 C/T cg00934597 chr7:893267 UNC84A 0.51 11.27 0.41 5.35e-27 Perceived unattractiveness to mosquitoes; BRCA cis rs425277 0.606 rs262669 chr1:2082489 A/G cg04315214 chr1:2043799 PRKCZ 0.48 12.56 0.45 1.63e-32 Height; BRCA trans rs7824557 0.843 rs2736375 chr8:11115749 C/T cg08975724 chr8:8085496 FLJ10661 -0.43 -8.36 -0.31 3.97e-16 Retinal vascular caliber; BRCA cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg11301795 chr4:187892539 NA -0.27 -8.81 -0.33 1.17e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg20607798 chr8:58055168 NA 0.48 8.36 0.31 3.99e-16 Developmental language disorder (linguistic errors); BRCA cis rs524281 0.861 rs7935336 chr11:65865325 C/T cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 4.15e-15 Electroencephalogram traits; BRCA cis rs2267137 0.868 rs174770 chr22:29766895 C/T cg07256473 chr22:29710276 RASL10A 0.36 8.78 0.33 1.46e-17 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs939658 0.805 rs2010524 chr15:79435825 G/T cg17916960 chr15:79447300 NA -0.45 -11.22 -0.41 8.53e-27 Refractive error; BRCA cis rs9291683 0.632 rs7679916 chr4:10042160 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.45 0.32 1.96e-16 Bone mineral density; BRCA cis rs6500602 0.964 rs13335685 chr16:4469284 T/C cg08645402 chr16:4508243 NA 0.37 8.81 0.33 1.14e-17 Schizophrenia; BRCA cis rs2204008 0.774 rs2387811 chr12:38369794 C/A cg26384229 chr12:38710491 ALG10B 0.76 17.15 0.56 1.68e-54 Bladder cancer; BRCA cis rs6842047 0.563 rs10025990 chr4:187146258 T/C cg09526685 chr4:187126073 CYP4V2 0.87 9.03 0.34 2.07e-18 Blood protein levels; BRCA trans rs208520 0.874 rs208456 chr6:66907942 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -15.98 -0.53 1.37e-48 Exhaled nitric oxide output; BRCA cis rs4363385 0.818 rs532743 chr1:153011758 T/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.27 -0.34 2.84e-19 Inflammatory skin disease; BRCA cis rs765787 0.530 rs4775834 chr15:45537511 C/T cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.71e-15 Uric acid levels; BRCA cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.99e-35 Bone mineral density; BRCA cis rs514406 0.679 rs541852 chr1:53256834 A/G cg08859206 chr1:53392774 SCP2 0.67 13.8 0.48 4.09e-38 Monocyte count; BRCA cis rs73086581 0.838 rs56401022 chr20:4024281 A/G cg02187196 chr20:3869020 PANK2 0.5 9.23 0.34 4.07e-19 Response to antidepressants in depression; BRCA trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg22491629 chr6:157744540 C6orf35 -0.68 -12.56 -0.44 1.79e-32 Hemostatic factors and hematological phenotypes; BRCA cis rs11098499 0.863 rs13136462 chr4:120543173 C/T cg09307838 chr4:120376055 NA 0.68 13.64 0.47 2.39e-37 Corneal astigmatism; BRCA cis rs757081 0.667 rs12577388 chr11:17101155 C/T cg15432903 chr11:17409602 KCNJ11 -0.46 -8.59 -0.32 6.73e-17 Systolic blood pressure; BRCA cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.35 -0.38 2.65e-23 Reticulocyte count; BRCA cis rs921968 0.509 rs832813 chr2:219354569 T/C cg02176678 chr2:219576539 TTLL4 0.43 10.99 0.4 7.63e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs9733 0.688 rs12725667 chr1:150766070 A/T cg13175981 chr1:150552382 MCL1 0.42 9.4 0.35 9.26e-20 Tonsillectomy; BRCA cis rs9640161 0.830 rs17173682 chr7:150059602 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.55 -12.94 -0.46 3.61e-34 Blood protein levels;Circulating chemerin levels; BRCA cis rs7264396 0.887 rs224354 chr20:34054609 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.32 -0.31 5.29e-16 Total cholesterol levels; BRCA trans rs11764590 0.715 rs11766468 chr7:2082604 G/A cg11693508 chr17:37793320 STARD3 0.53 8.98 0.33 3.03e-18 Neuroticism; BRCA cis rs7246657 0.943 rs7252346 chr19:37914682 G/A cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs7267979 0.932 rs367666 chr20:25449818 T/C cg08601574 chr20:25228251 PYGB 0.34 7.93 0.3 9.57e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs79976124 0.797 rs74995761 chr6:66640216 G/A cg07460842 chr6:66804631 NA 0.6 10.34 0.38 2.78e-23 Type 2 diabetes; BRCA cis rs9503598 0.636 rs7766753 chr6:3467708 A/C cg00476032 chr6:3446245 SLC22A23 0.38 8.83 0.33 9.92e-18 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs3784262 0.564 rs34958088 chr15:58328332 G/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.35 -0.38 2.56e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2153535 0.584 rs55945625 chr6:8371367 C/T cg23788917 chr6:8435910 SLC35B3 -0.43 -9.27 -0.34 2.91e-19 Motion sickness; BRCA cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg20818283 chr2:191399100 TMEM194B 0.43 9.81 0.36 3.05e-21 Pulse pressure; BRCA cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.14 -0.31 2.1e-15 Depression; BRCA cis rs9467773 0.596 rs2451750 chr6:26646579 A/T cg11502198 chr6:26597334 ABT1 0.56 12.02 0.43 3.88e-30 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.701 rs62248439 chr3:46996448 A/G cg16586182 chr3:47516702 SCAP 0.54 11.85 0.42 1.93e-29 Colorectal cancer; BRCA cis rs1451375 0.698 rs12669770 chr7:50656334 G/A cg18232548 chr7:50535776 DDC 0.4 9.25 0.34 3.2e-19 Malaria; BRCA cis rs6831352 0.734 rs1311620 chr4:100013091 C/T cg12011299 chr4:100065546 ADH4 0.41 10.2 0.37 9.45e-23 Alcohol dependence; BRCA cis rs1868673 1.000 rs1450344 chr3:150185745 G/A cg04908077 chr3:150187338 NA -0.32 -8.61 -0.32 5.76e-17 Waist circumference; BRCA trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.14 0.34 7.88e-19 Resting heart rate; BRCA trans rs8062405 1.000 rs8062405 chr16:28837906 C/T cg09719594 chr16:21412588 NA 0.33 8.07 0.3 3.6e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1005277 0.579 rs2474599 chr10:38438939 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -16.41 -0.54 9.23e-51 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg08917208 chr2:24149416 ATAD2B 0.93 13.82 0.48 3.34e-38 Lymphocyte counts; BRCA cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg01448562 chr3:133502909 NA -0.74 -18.35 -0.59 1.04e-60 Iron status biomarkers; BRCA cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.29 0.49 2.05e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs701145 0.556 rs357502 chr3:153955950 C/T cg16511985 chr3:153974050 SGEF 0.46 10.59 0.39 3.09e-24 Coronary artery disease; BRCA cis rs36051895 0.659 rs12343065 chr9:5083533 C/T cg02405213 chr9:5042618 JAK2 -0.55 -9.62 -0.36 1.52e-20 Pediatric autoimmune diseases; BRCA cis rs514406 0.679 rs499239 chr1:53310594 A/G cg01802117 chr1:53393560 SCP2 -0.4 -9.0 -0.34 2.61e-18 Monocyte count; BRCA cis rs2304069 0.913 rs3812009 chr5:149380159 G/C cg10852222 chr5:149380144 HMGXB3;TIGD6 0.54 8.4 0.32 2.86e-16 HIV-1 control; BRCA cis rs586533 0.881 rs683621 chr11:99501423 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2011503 0.941 rs80146298 chr19:19426317 C/T cg11584989 chr19:19387371 SF4 0.69 13.59 0.47 3.96e-37 Bipolar disorder; BRCA cis rs11122272 0.668 rs2472261 chr1:231505701 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -11.68 -0.42 1.01e-28 Hemoglobin concentration; BRCA cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg11941060 chr3:133502564 NA -0.51 -12.03 -0.43 3.31e-30 Iron status biomarkers; BRCA cis rs2016266 0.929 rs7399003 chr12:53659536 C/T cg26875137 chr12:53738046 NA 0.35 9.71 0.36 6.92e-21 Bone mineral density (spine);Bone mineral density; BRCA trans rs526821 0.595 rs551665 chr11:55343268 G/A cg15704280 chr7:45808275 SEPT13 -0.42 -7.84 -0.3 1.92e-14 Pediatric bone mineral density (spine); BRCA trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg27661571 chr11:113659931 NA -0.82 -12.19 -0.43 7.07e-31 Hip circumference adjusted for BMI; BRCA cis rs66887589 0.616 rs6843509 chr4:120220196 G/A cg09307838 chr4:120376055 NA 0.46 9.58 0.35 2.17e-20 Diastolic blood pressure; BRCA cis rs7568458 0.709 rs56819945 chr2:85755139 C/T cg02493740 chr2:85810744 VAMP5 -0.53 -10.91 -0.4 1.6e-25 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7020830 0.867 rs55845273 chr9:37362219 C/T cg14294708 chr9:37120828 ZCCHC7 1.12 35.95 0.82 1.25e-155 Schizophrenia; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg27588902 chr6:42928151 GNMT -0.3 -9.88 -0.36 1.63e-21 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9649213 0.574 rs7802560 chr7:97903806 A/G cg24562669 chr7:97807699 LMTK2 -0.43 -11.34 -0.41 2.67e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs3741404 0.609 rs641378 chr11:63869493 T/C cg18225595 chr11:63971243 STIP1 0.4 9.85 0.36 2.04e-21 Platelet count; BRCA cis rs6060717 0.536 rs6060699 chr20:34523833 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -10.63 -0.39 2.13e-24 Hip circumference adjusted for BMI; BRCA cis rs10851411 0.697 rs12439377 chr15:42861362 C/T cg21293051 chr15:42870591 STARD9 0.51 8.82 0.33 1.05e-17 Glucose homeostasis traits; BRCA cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg11764359 chr7:65958608 NA 0.8 18.81 0.6 4.01e-63 Aortic root size; BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg16606324 chr3:10149918 C3orf24 0.5 9.56 0.35 2.53e-20 Alzheimer's disease; BRCA cis rs1003719 0.843 rs1003721 chr21:38492657 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.57 13.04 0.46 1.19e-34 Eye color traits; BRCA cis rs875971 0.830 rs778715 chr7:65849209 C/T cg18876405 chr7:65276391 NA 0.52 11.67 0.42 1.13e-28 Aortic root size; BRCA cis rs6752107 0.791 rs3792106 chr2:234190740 A/G cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.41 8.77 0.33 1.64e-17 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg26384229 chr12:38710491 ALG10B 0.75 17.0 0.56 9.67e-54 Bladder cancer; BRCA cis rs11098499 0.954 rs9998585 chr4:120396802 T/A cg09307838 chr4:120376055 NA 0.72 15.33 0.52 2.14e-45 Corneal astigmatism; BRCA cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg03474202 chr17:45855739 NA -0.47 -12.49 -0.44 3.33e-32 IgG glycosylation; BRCA cis rs7789940 1.000 rs73140069 chr7:75986790 T/A cg10167463 chr7:75959203 YWHAG -0.44 -8.8 -0.33 1.31e-17 Multiple sclerosis; BRCA cis rs6460942 0.915 rs75732743 chr7:12454095 C/T cg06484146 chr7:12443880 VWDE -0.75 -10.68 -0.39 1.35e-24 Coronary artery disease; BRCA cis rs7412746 0.611 rs10888391 chr1:150729983 G/A cg15448220 chr1:150897856 SETDB1 0.37 8.29 0.31 6.49e-16 Melanoma; BRCA cis rs698833 0.521 rs35627501 chr2:44506971 G/C cg04920474 chr2:44395004 PPM1B 0.38 8.92 0.33 4.82e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg25214090 chr10:38739885 LOC399744 0.53 12.03 0.43 3.51e-30 Corneal astigmatism; BRCA cis rs10463316 0.894 rs10042030 chr5:150768028 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.33 -0.31 4.91e-16 Metabolite levels (Pyroglutamine); BRCA cis rs1552244 1.000 rs6772315 chr3:10113644 G/A cg08888203 chr3:10149979 C3orf24 0.67 14.02 0.49 3.85e-39 Alzheimer's disease; BRCA cis rs561341 1.000 rs4795668 chr17:30244554 G/A cg12193833 chr17:30244370 NA -0.62 -9.96 -0.37 8.2e-22 Hip circumference adjusted for BMI; BRCA cis rs651907 0.557 rs11924013 chr3:101366698 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.6 16.42 0.54 8.59e-51 Colorectal cancer; BRCA trans rs2736337 0.532 rs6998387 chr8:11293458 C/T cg06636001 chr8:8085503 FLJ10661 0.44 8.77 0.33 1.61e-17 Rheumatoid arthritis; BRCA cis rs6831352 0.918 rs7670638 chr4:100059807 G/C cg12011299 chr4:100065546 ADH4 -0.51 -11.76 -0.42 5.05e-29 Alcohol dependence; BRCA cis rs1569175 0.655 rs166847 chr2:200840612 A/G cg23649088 chr2:200775458 C2orf69 -0.65 -8.28 -0.31 7.49e-16 Response to treatment for acute lymphoblastic leukemia; BRCA cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.07 -0.34 1.44e-18 Developmental language disorder (linguistic errors); BRCA cis rs7635838 0.684 rs2594966 chr3:11325276 A/G cg00170343 chr3:11313890 ATG7 -0.41 -8.5 -0.32 1.35e-16 HDL cholesterol; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg07343612 chr16:622815 PIGQ -0.68 -22.12 -0.66 6.29e-81 Height; BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg15112475 chr7:1198522 ZFAND2A -0.36 -8.28 -0.31 7.47e-16 Longevity;Endometriosis; BRCA cis rs17376456 1.000 rs34854140 chr5:93538169 G/A cg21475434 chr5:93447410 FAM172A 0.69 9.16 0.34 6.78e-19 Diabetic retinopathy; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg03188948 chr7:1209495 NA 0.54 9.92 0.37 1.13e-21 Longevity;Endometriosis; BRCA cis rs10876993 0.928 rs1678532 chr12:58055197 T/G cg00677455 chr12:58241039 CTDSP2 -0.35 -8.02 -0.3 5e-15 Celiac disease or Rheumatoid arthritis; BRCA cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg20503657 chr10:835505 NA -1.28 -21.13 -0.64 1.38e-75 Eosinophil percentage of granulocytes; BRCA cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg06713675 chr4:122721982 EXOSC9 -0.53 -12.37 -0.44 1.19e-31 Type 2 diabetes; BRCA cis rs7264396 0.690 rs2425178 chr20:34446395 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.13 0.31 2.28e-15 Total cholesterol levels; BRCA cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.39 -0.38 1.87e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs72781680 0.898 rs17509001 chr2:24021231 T/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs4845875 0.600 rs4846040 chr1:11837048 C/G cg24844545 chr1:11908347 NPPA 0.37 8.68 0.32 3.35e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs9527 0.615 rs7096452 chr10:104736563 G/A cg04362960 chr10:104952993 NT5C2 0.46 10.73 0.39 8.24e-25 Arsenic metabolism; BRCA cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg27398817 chr8:82754497 SNX16 0.49 9.26 0.34 2.97e-19 Diastolic blood pressure; BRCA cis rs11252926 0.801 rs12358553 chr10:558014 C/T cg18196295 chr10:418757 DIP2C -0.49 -10.07 -0.37 3.05e-22 Psychosis in Alzheimer's disease; BRCA cis rs8114671 0.562 rs6060064 chr20:33406339 C/G cg24642439 chr20:33292090 TP53INP2 -0.42 -8.93 -0.33 4.63e-18 Height; BRCA cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.33 0.38 3.11e-23 Bipolar disorder; BRCA cis rs9790314 0.779 rs12493960 chr3:160899772 T/C cg04691961 chr3:161091175 C3orf57 -0.51 -11.13 -0.4 1.98e-26 Morning vs. evening chronotype; BRCA cis rs67981189 0.896 rs2810100 chr14:71432172 C/A cg15816911 chr14:71606274 NA -0.35 -7.94 -0.3 9.17e-15 Schizophrenia; BRCA trans rs11088226 0.681 rs11702499 chr21:33938565 C/T cg09050820 chr6:167586206 TCP10L2 0.77 13.24 0.46 1.49e-35 Gastritis; BRCA cis rs8062405 0.965 rs8049439 chr16:28837515 A/G cg09754948 chr16:28834200 ATXN2L 0.38 7.94 0.3 9e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs600231 0.683 rs588298 chr11:65253574 A/G cg01292856 chr11:65242576 NA 0.33 8.0 0.3 5.89e-15 Bone mineral density; BRCA trans rs11088226 0.846 rs13047501 chr21:33924660 G/A cg09050820 chr6:167586206 TCP10L2 0.57 10.88 0.4 2.15e-25 Gastritis; BRCA cis rs7617773 0.817 rs6801801 chr3:48326433 T/C cg11946769 chr3:48343235 NME6 0.62 13.68 0.48 1.48e-37 Coronary artery disease; BRCA cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg06159980 chr1:16340746 HSPB7 -0.38 -7.95 -0.3 8.43e-15 Dilated cardiomyopathy; BRCA trans rs12310956 0.532 rs2171534 chr12:33838998 C/T cg26384229 chr12:38710491 ALG10B 0.44 10.0 0.37 5.63e-22 Morning vs. evening chronotype; BRCA cis rs798554 0.836 rs798526 chr7:2775542 G/C cg19346786 chr7:2764209 NA -0.35 -10.56 -0.39 3.95e-24 Height; BRCA cis rs6960043 0.818 rs10238161 chr7:15053827 A/T cg19272540 chr7:15055459 NA 0.22 7.94 0.3 9.27e-15 Type 2 diabetes; BRCA cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 11.72 0.42 7.01e-29 Bipolar disorder; BRCA cis rs7255436 0.965 rs11666233 chr19:8452045 G/T cg10811474 chr19:8428787 ANGPTL4 -0.34 -8.74 -0.33 2.13e-17 HDL cholesterol; BRCA cis rs739401 0.611 rs7109088 chr11:3027485 G/T cg25174290 chr11:3078921 CARS 0.43 12.96 0.46 2.94e-34 Longevity; BRCA trans rs10506458 0.688 rs73127095 chr12:63418283 T/G cg03429785 chr15:59498649 MYO1E;LDHAL6B -0.86 -15.01 -0.51 7.95e-44 Hemostatic factors and hematological phenotypes; BRCA cis rs7572733 0.555 rs35563720 chr2:198923075 A/G cg00792783 chr2:198669748 PLCL1 0.39 8.48 0.32 1.62e-16 Dermatomyositis; BRCA cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6546550 0.901 rs3732266 chr2:70057448 T/G cg02498382 chr2:70120550 SNRNP27 -0.51 -10.65 -0.39 1.69e-24 Prevalent atrial fibrillation; BRCA cis rs826838 0.654 rs7977738 chr12:38722460 G/A cg13010199 chr12:38710504 ALG10B 0.33 7.94 0.3 9.36e-15 Heart rate; BRCA cis rs2479724 0.755 rs4318867 chr6:41753670 G/T cg17623882 chr6:41773611 USP49 0.33 8.85 0.33 8.49e-18 Menarche (age at onset); BRCA cis rs2380220 0.606 rs4559095 chr6:95994154 A/C cg15832292 chr6:96025679 MANEA 0.5 8.04 0.3 4.51e-15 Behavioural disinhibition (generation interaction); BRCA cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs8141529 0.702 rs132536 chr22:29302906 A/G cg15103426 chr22:29168792 CCDC117 -0.51 -12.17 -0.43 8.71e-31 Lymphocyte counts; BRCA cis rs7959452 0.562 rs11177630 chr12:69767963 G/C cg22834771 chr12:69754056 YEATS4 -0.39 -9.64 -0.36 1.29e-20 Blood protein levels; BRCA cis rs2742234 0.955 rs2503849 chr10:43672776 G/A cg15436174 chr10:43711423 RASGEF1A -0.43 -8.91 -0.33 5.1e-18 Hirschsprung disease; BRCA cis rs60843830 0.928 rs55742348 chr2:217563 T/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 18.28 0.59 2.22e-60 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9309711 0.922 rs7561600 chr2:3486093 G/C cg10845886 chr2:3471009 TTC15 -0.74 -15.74 -0.53 2.05e-47 Neurofibrillary tangles; BRCA cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg17366294 chr4:99064904 C4orf37 -0.45 -10.78 -0.39 5.04e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.698 rs10773178 chr12:122944752 T/C cg05707623 chr12:122985044 ZCCHC8 -0.45 -9.25 -0.34 3.29e-19 Body mass index; BRCA trans rs9650657 0.504 rs10109167 chr8:11033525 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -10.93 -0.4 1.27e-25 Neuroticism; BRCA cis rs9467773 0.572 rs3846846 chr6:26445039 A/G cg09904177 chr6:26538194 HMGN4 -0.37 -9.81 -0.36 3.06e-21 Intelligence (multi-trait analysis); BRCA cis rs7586879 0.639 rs2033653 chr2:25103446 C/T cg01884057 chr2:25150051 NA -0.33 -8.84 -0.33 9.21e-18 Body mass index; BRCA cis rs1843834 0.539 rs12694643 chr2:225446603 A/G cg22455342 chr2:225449267 CUL3 0.63 16.53 0.55 2.23e-51 IgE levels in asthmatics (D.p. specific); BRCA cis rs6541297 0.938 rs1555289 chr1:230292499 C/T cg20703242 chr1:230279135 GALNT2 -0.46 -9.52 -0.35 3.57e-20 Coronary artery disease; BRCA cis rs2710642 0.861 rs2710644 chr2:63248968 A/C cg17519650 chr2:63277830 OTX1 0.42 8.68 0.32 3.35e-17 LDL cholesterol levels;LDL cholesterol; BRCA trans rs6582630 0.502 rs1915395 chr12:38420726 A/G cg06521331 chr12:34319734 NA -0.51 -9.21 -0.34 4.77e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs61931739 0.500 rs11053282 chr12:34561151 T/C cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs2011503 0.941 rs56278919 chr19:19367190 A/G cg11584989 chr19:19387371 SF4 0.66 14.35 0.49 1.12e-40 Bipolar disorder; BRCA cis rs478304 0.651 rs11532071 chr11:65500198 C/A cg10518572 chr11:65560635 OVOL1 -0.3 -8.41 -0.32 2.71e-16 Acne (severe); BRCA cis rs9837602 1.000 rs793499 chr3:99565576 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -11.06 -0.4 3.81e-26 Breast cancer; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg03923535 chr7:1197113 ZFAND2A 0.53 11.0 0.4 6.73e-26 Longevity;Endometriosis; BRCA cis rs875971 0.862 rs6460279 chr7:65662761 T/C cg18876405 chr7:65276391 NA -0.5 -11.23 -0.41 7.86e-27 Aortic root size; BRCA cis rs7945718 0.905 rs10831908 chr11:12812419 G/A cg25843174 chr11:12811716 TEAD1 0.25 9.35 0.35 1.41e-19 Educational attainment (years of education); BRCA cis rs9467711 0.606 rs4634439 chr6:26598004 C/T cg12826209 chr6:26865740 GUSBL1 -0.59 -7.96 -0.3 8.15e-15 Autism spectrum disorder or schizophrenia; BRCA trans rs6076960 0.629 rs6054008 chr20:6212370 C/T cg17788362 chr6:86352627 SYNCRIP 0.43 8.45 0.32 1.93e-16 Smooth-surface caries; BRCA cis rs738322 0.775 rs4375 chr22:38539041 T/C cg20207973 chr22:38506712 BAIAP2L2 0.32 8.1 0.31 2.75e-15 Cutaneous nevi; BRCA cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg20090143 chr19:45452003 APOC2 0.27 8.04 0.3 4.46e-15 Blood protein levels; BRCA cis rs6545883 0.894 rs12620105 chr2:61512321 A/T cg15711740 chr2:61764176 XPO1 0.51 12.3 0.44 2.46e-31 Tuberculosis; BRCA cis rs812925 0.502 rs6545868 chr2:61655365 T/C cg15711740 chr2:61764176 XPO1 0.33 8.16 0.31 1.76e-15 Immature fraction of reticulocytes; BRCA cis rs2084898 0.527 rs605374 chr11:120005633 A/C cg07435449 chr11:120005650 TRIM29 0.36 8.82 0.33 1.12e-17 Stroke (pediatric); BRCA cis rs66887589 0.592 rs62320740 chr4:120279486 C/A cg09307838 chr4:120376055 NA 0.49 10.72 0.39 9.2e-25 Diastolic blood pressure; BRCA cis rs2153535 0.580 rs2184582 chr6:8447793 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs35146811 0.624 rs1727134 chr7:99813672 T/C cg22906224 chr7:99728672 NA -0.42 -7.87 -0.3 1.54e-14 Coronary artery disease; BRCA cis rs9487051 0.735 rs396000 chr6:109519611 A/G cg21918786 chr6:109611834 NA 0.36 9.53 0.35 3.25e-20 Reticulocyte fraction of red cells; BRCA cis rs1008375 1.000 rs2315561 chr4:17679695 C/T cg16339924 chr4:17578868 LAP3 0.59 14.46 0.5 3.17e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9467711 0.659 rs13220261 chr6:26499185 C/T cg01620082 chr3:125678407 NA -0.7 -8.64 -0.32 4.42e-17 Autism spectrum disorder or schizophrenia; BRCA trans rs9858542 0.953 rs6766131 chr3:49538932 T/C cg21659725 chr3:3221576 CRBN -0.46 -9.91 -0.36 1.27e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7715811 0.913 rs4368727 chr5:13770248 C/T cg07548982 chr5:13769939 DNAH5 -0.38 -8.45 -0.32 2.01e-16 Subclinical atherosclerosis traits (other); BRCA cis rs875971 0.571 rs160647 chr7:65554352 C/T cg11764359 chr7:65958608 NA -0.63 -11.2 -0.41 1.04e-26 Aortic root size; BRCA cis rs4727027 0.865 rs12154368 chr7:148862041 C/T cg23583168 chr7:148888333 NA -0.86 -20.07 -0.62 7.29e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6542838 0.641 rs11123756 chr2:99508012 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.4 8.89 0.33 6.44e-18 Fear of minor pain; BRCA cis rs7617773 0.743 rs11715876 chr3:48377922 G/A cg11946769 chr3:48343235 NME6 0.66 13.23 0.46 1.71e-35 Coronary artery disease; BRCA cis rs35110281 0.811 rs7275705 chr21:45056453 G/C cg04455712 chr21:45112962 RRP1B 0.38 9.78 0.36 3.69e-21 Mean corpuscular volume; BRCA cis rs8062405 0.723 rs4788077 chr16:28569764 G/C cg16576597 chr16:28551801 NUPR1 0.35 8.79 0.33 1.39e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs1493916 0.748 rs1389535 chr18:31310416 A/G cg27147174 chr7:100797783 AP1S1 0.42 8.36 0.31 3.89e-16 Life satisfaction; BRCA trans rs6952808 0.630 rs4719443 chr7:2161099 A/G cg04565464 chr8:145669602 NFKBIL2 0.38 8.6 0.32 6.2e-17 Bipolar disorder and schizophrenia; BRCA cis rs7072216 0.763 rs45523432 chr10:100167436 T/C cg26618903 chr10:100175079 PYROXD2 -0.31 -8.96 -0.33 3.58e-18 Metabolite levels; BRCA cis rs2964802 0.617 rs13174269 chr5:10804759 C/T cg14521931 chr5:10832172 NA -0.45 -10.02 -0.37 4.68e-22 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs600231 0.542 rs10896008 chr11:65245904 C/G cg01292856 chr11:65242576 NA 0.67 14.67 0.5 3.4e-42 Bone mineral density; BRCA cis rs9399137 0.507 rs4896129 chr6:135349845 C/T cg24558204 chr6:135376177 HBS1L 0.59 16.06 0.54 5.41e-49 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg14926445 chr8:58193284 C8orf71 -0.41 -7.94 -0.3 9.14e-15 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.02 0.34 2.12e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6860806 0.507 rs272868 chr5:131680751 C/G cg12564285 chr5:131593104 PDLIM4 0.34 7.84 0.3 1.84e-14 Breast cancer; BRCA cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs7809950 1.000 rs10274041 chr7:107261556 C/T cg23024343 chr7:107201750 COG5 0.37 8.47 0.32 1.66e-16 Coronary artery disease; BRCA cis rs7786808 0.741 rs7789415 chr7:158227617 C/T cg09998033 chr7:158218633 PTPRN2 -0.39 -9.27 -0.34 2.81e-19 Obesity-related traits; BRCA cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.02 0.49 3.86e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4919694 1.000 rs12257941 chr10:104833161 C/T cg04362960 chr10:104952993 NT5C2 0.94 14.57 0.5 1.01e-41 Arsenic metabolism; BRCA cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg24675658 chr1:53192096 ZYG11B -0.58 -13.34 -0.47 5.51e-36 Monocyte count; BRCA cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg13770153 chr20:60521292 NA -0.45 -10.67 -0.39 1.43e-24 Body mass index; BRCA cis rs2839186 0.933 rs4818832 chr21:47708634 C/T cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs514406 0.929 rs557715 chr1:53321593 C/G cg25767906 chr1:53392781 SCP2 -0.39 -8.85 -0.33 8.59e-18 Monocyte count; BRCA cis rs12477438 0.539 rs12999417 chr2:99865548 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.7 -17.83 -0.58 4.93e-58 Chronic sinus infection; BRCA cis rs1801251 1.000 rs2674839 chr2:233669040 G/C cg08000102 chr2:233561755 GIGYF2 0.62 13.23 0.46 1.69e-35 Coronary artery disease; BRCA trans rs4714291 0.963 rs1721412 chr6:40100606 T/G cg02267698 chr19:7991119 CTXN1 0.43 8.41 0.32 2.76e-16 Strep throat; BRCA trans rs11098499 0.909 rs7659501 chr4:120371552 G/T cg25214090 chr10:38739885 LOC399744 0.56 12.85 0.45 9.31e-34 Corneal astigmatism; BRCA cis rs1401999 1.000 rs7632670 chr3:183713877 A/G cg01324343 chr3:183735012 ABCC5 0.85 21.71 0.65 1.08e-78 Anterior chamber depth; BRCA cis rs4595586 0.546 rs11609849 chr12:39258090 C/G cg13010199 chr12:38710504 ALG10B 0.44 8.77 0.33 1.67e-17 Morning vs. evening chronotype; BRCA cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg19784903 chr17:45786737 TBKBP1 0.34 8.13 0.31 2.24e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs35110281 0.807 rs28840140 chr21:45039163 T/C cg01579765 chr21:45077557 HSF2BP -0.39 -10.49 -0.38 7.18e-24 Mean corpuscular volume; BRCA cis rs703842 1.000 rs703842 chr12:58162739 C/T cg04478727 chr12:58166393 METTL1;FAM119B -0.54 -11.4 -0.41 1.49e-27 Multiple sclerosis; BRCA cis rs7980687 0.628 rs1609520 chr12:123735937 A/G cg00376283 chr12:123451042 ABCB9 -0.54 -13.65 -0.48 2.09e-37 Height;Educational attainment;Head circumference (infant); BRCA cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg15112475 chr7:1198522 ZFAND2A 0.37 8.07 0.3 3.59e-15 Longevity;Endometriosis; BRCA cis rs210143 1 rs210143 chr6:33546930 T/C cg24505687 chr6:33548425 BAK1 0.57 12.15 0.43 1e-30 Neutrophil percentage of granulocytes;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy);Chronic lymphocytic leukemia; BRCA cis rs2274273 0.840 rs943590 chr14:55738596 T/C cg04306507 chr14:55594613 LGALS3 0.3 8.51 0.32 1.21e-16 Protein biomarker; BRCA cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.76 -0.57 1.24e-57 Chronic sinus infection; BRCA cis rs2412208 0.509 rs7546792 chr1:7124346 C/T cg20434152 chr1:7120926 CAMTA1 -0.39 -9.58 -0.35 2.07e-20 Survival in sporadic amyotrophic lateral sclerosis; BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.2 0.6 3.14e-65 Alzheimer's disease; BRCA trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg17788362 chr6:86352627 SYNCRIP 0.4 8.14 0.31 2.04e-15 Smooth-surface caries; BRCA cis rs17376456 0.877 rs17083462 chr5:93462401 T/G cg21475434 chr5:93447410 FAM172A 0.67 9.1 0.34 1.1e-18 Diabetic retinopathy; BRCA cis rs1580019 0.713 rs2122632 chr7:32524686 A/G cg06627557 chr7:32535165 LSM5;AVL9 -1.01 -26.37 -0.72 2.85e-104 Cognitive ability; BRCA cis rs853679 0.517 rs9348797 chr6:28137533 G/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs3739998 0.509 rs61841115 chr10:30333025 C/T cg12786570 chr10:30316432 KIAA1462 0.48 9.52 0.35 3.47e-20 Coronary heart disease; BRCA trans rs7618501 1.000 rs11716575 chr3:49744890 A/G cg21659725 chr3:3221576 CRBN -0.71 -21.8 -0.65 3.27e-79 Intelligence (multi-trait analysis); BRCA trans rs10242455 0.557 rs73401516 chr7:99068351 C/A cg09045935 chr12:6379348 NA 0.84 8.4 0.32 2.93e-16 Blood metabolite levels; BRCA trans rs2204008 0.558 rs66545149 chr12:38204694 A/G cg06521331 chr12:34319734 NA -0.54 -9.56 -0.35 2.48e-20 Bladder cancer; BRCA cis rs12618769 0.597 rs55900716 chr2:99109132 G/A cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs12210905 0.688 rs9393814 chr6:27372978 C/T cg08851530 chr6:28072375 NA 0.84 8.27 0.31 7.72e-16 Hip circumference adjusted for BMI; BRCA cis rs11105298 0.891 rs10506972 chr12:89861529 T/C cg00757033 chr12:89920650 WDR51B 0.53 10.71 0.39 1.02e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs10779751 0.686 rs1148478 chr1:11174067 A/T cg08854313 chr1:11322531 MTOR 0.73 14.45 0.5 3.64e-41 Body mass index; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg16606324 chr3:10149918 C3orf24 0.57 11.01 0.4 5.98e-26 Alzheimer's disease; BRCA cis rs6570726 0.818 rs9390338 chr6:145908265 A/G cg23711669 chr6:146136114 FBXO30 0.73 17.3 0.56 2.77e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs7474896 0.515 rs624359 chr10:38299132 T/C cg25427524 chr10:38739819 LOC399744 0.51 9.43 0.35 7.31e-20 Obesity (extreme); BRCA cis rs62064224 0.589 rs9889607 chr17:30785585 A/C cg18200150 chr17:30822561 MYO1D -0.35 -9.08 -0.34 1.36e-18 Schizophrenia; BRCA trans rs11098499 0.739 rs951570 chr4:120150467 T/C cg25214090 chr10:38739885 LOC399744 -0.46 -9.77 -0.36 4.32e-21 Corneal astigmatism; BRCA cis rs7666738 0.791 rs2081622 chr4:98927369 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.562 rs6901765 chr6:8455436 A/T cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA trans rs8002861 0.935 rs9533672 chr13:44451180 C/T cg17145862 chr1:211918768 LPGAT1 0.7 18.33 0.59 1.24e-60 Leprosy; BRCA cis rs1215050 0.716 rs11940331 chr4:99054041 G/C cg05340658 chr4:99064831 C4orf37 0.5 11.64 0.42 1.48e-28 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs3092073 0.624 rs13040315 chr20:44585793 A/G cg17986701 chr20:44574422 PCIF1 0.37 8.87 0.33 7.22e-18 Intelligence (multi-trait analysis); BRCA trans rs4689592 0.513 rs3857177 chr4:7066332 G/A cg07817883 chr1:32538562 TMEM39B -0.44 -8.52 -0.32 1.12e-16 Monocyte percentage of white cells; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg01262667 chr19:19385393 TM6SF2 0.42 10.97 0.4 9.28e-26 Tonsillectomy; BRCA cis rs514406 0.621 rs881198 chr1:53196440 C/T cg24675658 chr1:53192096 ZYG11B 0.62 13.91 0.48 1.31e-38 Monocyte count; BRCA cis rs12477438 0.520 rs11123763 chr2:99750673 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.84 0.67 7.19e-85 Chronic sinus infection; BRCA cis rs4862750 0.957 rs1030381 chr4:187903568 G/C cg10295955 chr4:187884368 NA -0.9 -26.36 -0.72 3.28e-104 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -11.98 -0.43 5.79e-30 Alzheimer's disease; BRCA cis rs2153535 0.580 rs986060 chr6:8465428 T/C cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs12540874 0.698 rs12718574 chr7:50573848 G/C cg18232548 chr7:50535776 DDC -0.53 -13.22 -0.46 1.99e-35 Systemic sclerosis; BRCA cis rs908922 0.676 rs945789 chr1:152512705 C/A cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA trans rs9944715 0.954 rs62096523 chr18:43737966 T/A cg01718231 chr17:29326311 RNF135 0.44 8.9 0.33 5.77e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg08885076 chr2:99613938 TSGA10 0.45 10.67 0.39 1.46e-24 Chronic sinus infection; BRCA cis rs6545883 0.630 rs12998475 chr2:61437487 T/C cg15711740 chr2:61764176 XPO1 0.45 10.9 0.4 1.7e-25 Tuberculosis; BRCA cis rs2882667 0.537 rs7704790 chr5:138410096 A/C cg04439458 chr5:138467593 SIL1 -0.3 -8.17 -0.31 1.6e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1878931 0.507 rs11648783 chr16:3406626 A/G cg02880119 chr16:3481970 NA -0.41 -7.98 -0.3 6.65e-15 Body mass index (adult); BRCA trans rs9329221 0.527 rs10903328 chr8:10332167 G/C cg15556689 chr8:8085844 FLJ10661 0.35 9.11 0.34 1.01e-18 Neuroticism; BRCA cis rs9457247 0.765 rs2237276 chr6:167442115 C/T cg07741184 chr6:167504864 NA 0.29 8.27 0.31 7.5e-16 Crohn's disease; BRCA cis rs9287719 0.967 rs13034061 chr2:10739651 C/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs7927771 0.864 rs4752838 chr11:47466006 G/A cg20307385 chr11:47447363 PSMC3 -0.42 -9.06 -0.34 1.61e-18 Subjective well-being; BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg23285459 chr7:2802560 GNA12 -0.37 -9.45 -0.35 6.14e-20 Height; BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13012494 chr21:47604986 C21orf56 0.44 8.92 0.33 5.06e-18 Testicular germ cell tumor; BRCA cis rs9790314 0.818 rs6797066 chr3:161008725 T/A cg04691961 chr3:161091175 C3orf57 -0.41 -10.17 -0.37 1.33e-22 Morning vs. evening chronotype; BRCA cis rs17767294 0.708 rs72848755 chr6:27878553 T/C cg08851530 chr6:28072375 NA 0.92 8.91 0.33 5.15e-18 Parkinson's disease; BRCA trans rs9951602 0.512 rs1599635 chr18:76643819 G/A cg02800362 chr5:177631904 HNRNPAB 0.76 17.56 0.57 1.25e-56 Obesity-related traits; BRCA cis rs798554 0.591 rs1713913 chr7:2895627 C/T cg04166393 chr7:2884313 GNA12 0.5 11.03 0.4 5.23e-26 Height; BRCA cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg18918831 chr3:195489782 MUC4 0.62 9.47 0.35 5.39e-20 Lung disease severity in cystic fibrosis; BRCA cis rs2204008 0.837 rs11519926 chr12:38348992 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.45 0.57 4.59e-56 Bladder cancer; BRCA cis rs116979167 0.575 rs67661063 chr7:105187259 T/G cg19920283 chr7:105172520 RINT1 0.44 9.21 0.34 4.45e-19 Bipolar disorder (body mass index interaction); BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg23285459 chr7:2802560 GNA12 -0.35 -8.62 -0.32 5.24e-17 Height; BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg22920501 chr2:26401640 FAM59B -0.9 -16.11 -0.54 3.04e-49 Gut microbiome composition (summer); BRCA cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg16506815 chr2:162101123 NA 0.72 18.1 0.58 1.99e-59 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA trans rs6582630 0.537 rs6582500 chr12:38534206 G/A cg06521331 chr12:34319734 NA -0.51 -9.36 -0.35 1.32e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs769267 0.930 rs2301784 chr19:19390749 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.87 0.36 1.77e-21 Tonsillectomy; BRCA cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg15017067 chr4:17643749 FAM184B 0.3 9.01 0.34 2.32e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2688608 0.592 rs7923045 chr10:75487498 A/T cg23231163 chr10:75533350 FUT11 -0.32 -8.35 -0.31 4.18e-16 Inflammatory bowel disease; BRCA cis rs13053817 1.000 rs13055556 chr22:29840367 A/G cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.49 -9.74 -0.36 5.3e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs4319547 0.626 rs11057882 chr12:122875046 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.34 -0.35 1.53e-19 Body mass index; BRCA cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs10540 1.000 rs35898083 chr11:484469 C/T cg15790184 chr11:494944 RNH1 0.64 9.54 0.35 2.93e-20 Body mass index; BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg00814883 chr7:100076585 TSC22D4 -0.54 -11.59 -0.42 2.56e-28 Platelet count; BRCA cis rs67981189 0.574 rs2010713 chr14:71368735 T/G cg15816911 chr14:71606274 NA -0.38 -8.83 -0.33 1e-17 Schizophrenia; BRCA cis rs9473147 0.516 rs9381564 chr6:47443806 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.25 0.34 3.42e-19 Platelet distribution width;Mean platelet volume; BRCA cis rs651907 0.557 rs3806654 chr3:101396529 G/C cg12386194 chr3:101231763 SENP7 0.39 8.42 0.32 2.48e-16 Colorectal cancer; BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg21782813 chr7:2030301 MAD1L1 -0.33 -9.45 -0.35 6.17e-20 Bipolar disorder and schizophrenia; BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg21143896 chr7:2802374 GNA12 -0.36 -8.97 -0.33 3.19e-18 Height; BRCA cis rs10789491 1.000 rs10789491 chr1:47179310 A/G cg15501359 chr1:47185051 KIAA0494 0.66 18.26 0.59 3.04e-60 Response to hepatitis C treatment; BRCA cis rs796364 0.806 rs34582889 chr2:201010527 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -8.62 -0.32 5.23e-17 Schizophrenia; BRCA cis rs2836950 0.805 rs62223042 chr21:40683740 A/G cg11890956 chr21:40555474 PSMG1 -0.52 -10.57 -0.39 3.44e-24 Menarche (age at onset); BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg18765753 chr7:1198926 ZFAND2A -0.57 -15.63 -0.53 7.37e-47 Longevity;Endometriosis; BRCA cis rs7552404 0.924 rs1251075 chr1:76190569 C/G cg10523679 chr1:76189770 ACADM 0.78 18.78 0.6 5.17e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.830 rs10856936 chr4:99011319 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.04e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg05707623 chr12:122985044 ZCCHC8 -0.52 -10.33 -0.38 3.09e-23 Body mass index; BRCA cis rs11083475 0.714 rs1471432 chr19:39260282 G/A cg07403899 chr19:39283540 NA -0.25 -8.3 -0.31 6.02e-16 Heart rate; BRCA cis rs6772849 0.930 rs4467479 chr3:128369055 C/G cg16766828 chr3:128327626 NA -0.4 -8.86 -0.33 7.7e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.91 0.4 1.61e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs807669 0.777 rs9605972 chr22:19253274 C/T cg02655711 chr22:19163373 SLC25A1 0.57 14.36 0.49 9.47e-41 Metabolite levels; BRCA cis rs2075371 0.796 rs7780583 chr7:133960716 C/G cg02659138 chr7:134003124 SLC35B4 0.36 10.36 0.38 2.37e-23 Mean platelet volume; BRCA cis rs3741404 0.609 rs651855 chr11:63870810 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.38 8.95 0.33 3.76e-18 Platelet count; BRCA cis rs1949733 0.598 rs869602 chr4:8535371 G/T cg13073564 chr4:8508604 NA 0.31 7.95 0.3 8.33e-15 Response to antineoplastic agents; BRCA cis rs1801251 1.000 rs2100053 chr2:233719516 G/T cg25237894 chr2:233734115 C2orf82 -0.41 -11.77 -0.42 4.34e-29 Coronary artery disease; BRCA cis rs4481887 0.927 rs10127803 chr1:248476196 A/T cg13385794 chr1:248469461 NA 0.27 7.85 0.3 1.75e-14 Common traits (Other); BRCA cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg02551604 chr5:131831745 NA -0.39 -14.68 -0.5 2.84e-42 Asthma (sex interaction); BRCA cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs7172677 0.737 rs6495154 chr15:75437262 G/C cg14664628 chr15:75095509 CSK -0.39 -8.05 -0.3 3.93e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7727544 0.716 rs11955347 chr5:131567924 G/A cg14196790 chr5:131705035 SLC22A5 0.4 10.23 0.38 7.44e-23 Blood metabolite levels; BRCA cis rs7772486 0.686 rs9403746 chr6:146103768 C/A cg23711669 chr6:146136114 FBXO30 -0.72 -17.09 -0.56 3.25e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg04025307 chr7:1156635 C7orf50 0.53 10.42 0.38 1.43e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs16976116 0.901 rs8027098 chr15:55492269 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.58 0.39 3.14e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs490234 0.552 rs3122938 chr9:128157326 A/G cg14078157 chr9:128172775 NA 0.43 10.2 0.37 9.92e-23 Mean arterial pressure; BRCA cis rs7917772 0.503 rs7902306 chr10:104290462 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 18.31 0.59 1.54e-60 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs600806 0.713 rs10857786 chr1:110010110 C/G cg20591472 chr1:110008990 SYPL2 0.31 7.98 0.3 6.93e-15 Intelligence (multi-trait analysis); BRCA cis rs1448094 0.512 rs1584368 chr12:86245117 A/C cg19622623 chr12:86230825 RASSF9 -0.35 -9.99 -0.37 6.37e-22 Major depressive disorder; BRCA cis rs16854884 0.657 rs1867608 chr3:143752938 G/A cg06585982 chr3:143692056 C3orf58 0.44 9.44 0.35 6.81e-20 Economic and political preferences (feminism/equality); BRCA cis rs597539 0.521 rs7943745 chr11:68605828 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.36 -7.96 -0.3 7.92e-15 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs651907 0.535 rs13085776 chr3:101505507 A/G cg12386194 chr3:101231763 SENP7 0.46 9.28 0.34 2.64e-19 Colorectal cancer; BRCA cis rs36051895 0.664 rs12340866 chr9:5094185 G/A cg02405213 chr9:5042618 JAK2 -0.5 -9.02 -0.34 2.13e-18 Pediatric autoimmune diseases; BRCA cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg16325326 chr1:53192061 ZYG11B -0.71 -18.64 -0.59 3.1e-62 Monocyte count; BRCA cis rs78487399 0.808 rs72865297 chr2:43743248 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.56 -7.96 -0.3 7.89e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs11112613 0.609 rs11112585 chr12:105933442 A/G cg03607813 chr12:105948248 NA -0.51 -8.03 -0.3 4.82e-15 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs7666738 0.546 rs7699578 chr4:98838893 T/C cg05340658 chr4:99064831 C4orf37 0.59 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9296092 0.538 rs5000098 chr6:33519231 T/G cg13560919 chr6:33536144 NA -0.85 -18.62 -0.59 3.9e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg05347473 chr6:146136440 FBXO30 0.54 10.4 0.38 1.68e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg04267008 chr7:1944627 MAD1L1 0.37 8.01 0.3 5.53e-15 Schizophrenia; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg07930192 chr7:1003750 NA -0.4 -8.65 -0.32 4.22e-17 Longevity;Endometriosis; BRCA trans rs1997103 1.000 rs2009441 chr7:55405989 A/G cg20935933 chr6:143382018 AIG1 0.6 11.55 0.42 3.6e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7103648 0.545 rs6485795 chr11:47929846 G/A cg03711944 chr11:47377212 SPI1 -0.36 -8.38 -0.31 3.29e-16 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg08088566 chr11:430123 ANO9 0.56 8.3 0.31 6.17e-16 Body mass index; BRCA cis rs7520050 0.966 rs1768816 chr1:46528599 T/C cg24296786 chr1:45957014 TESK2 0.41 9.17 0.34 6.24e-19 Red blood cell count;Reticulocyte count; BRCA trans rs75804782 0.581 rs13415491 chr2:239319901 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 9.69 0.36 8.3e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs6066825 0.644 rs6019393 chr20:47334435 G/C cg18078177 chr20:47281410 PREX1 0.38 9.42 0.35 8.09e-20 Colorectal cancer; BRCA cis rs67311347 1.000 rs11914297 chr3:40410070 T/C cg09455208 chr3:40491958 NA 0.41 9.56 0.35 2.42e-20 Renal cell carcinoma; BRCA trans rs867371 0.502 rs1846908 chr15:82522526 T/C cg04831495 chr15:85060580 GOLGA6L5 -0.33 -8.97 -0.33 3.15e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.3 -0.44 2.46e-31 Alzheimer's disease; BRCA cis rs7123876 0.587 rs184654 chr11:72364405 C/G cg03713592 chr11:72463424 ARAP1 0.59 9.45 0.35 6.41e-20 Body mass index; BRCA cis rs9649213 0.593 rs11760930 chr7:97915789 G/A cg24562669 chr7:97807699 LMTK2 0.44 11.85 0.42 2.01e-29 Prostate cancer (SNP x SNP interaction); BRCA trans rs8002861 0.870 rs4942255 chr13:44451844 A/T cg17145862 chr1:211918768 LPGAT1 -0.62 -14.95 -0.51 1.46e-43 Leprosy; BRCA cis rs35306767 0.855 rs61830932 chr10:934183 T/C cg26597838 chr10:835615 NA 1.0 17.58 0.57 1.05e-56 Eosinophil percentage of granulocytes; BRCA trans rs1941687 0.563 rs7238931 chr18:31334993 G/A cg15819921 chr19:927150 ARID3A -0.47 -8.94 -0.33 4.15e-18 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs6479891 1.000 rs12784772 chr10:65195455 T/A cg14819942 chr15:35414228 NA 0.35 8.6 0.32 6e-17 Arthritis (juvenile idiopathic); BRCA cis rs9733 0.596 rs11204687 chr1:150629880 C/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs875971 0.660 rs801211 chr7:66015689 T/G cg18876405 chr7:65276391 NA -0.62 -15.48 -0.52 3.8e-46 Aortic root size; BRCA cis rs7772486 0.806 rs2247317 chr6:146217570 C/T cg23711669 chr6:146136114 FBXO30 0.66 15.34 0.52 1.79e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs3125734 0.608 rs7905731 chr10:64018472 T/C cg19640130 chr10:64028056 RTKN2 -0.3 -8.5 -0.32 1.39e-16 Rheumatoid arthritis; BRCA cis rs3125734 0.582 rs7904465 chr10:64002393 G/A cg19640130 chr10:64028056 RTKN2 -0.32 -9.24 -0.34 3.61e-19 Rheumatoid arthritis; BRCA cis rs2576037 0.583 rs1970668 chr18:44523220 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.75 -0.39 7.03e-25 Personality dimensions; BRCA cis rs875971 0.545 rs73148639 chr7:65855329 A/T cg11764359 chr7:65958608 NA 0.65 11.55 0.42 3.54e-28 Aortic root size; BRCA cis rs9790314 0.638 rs1374793 chr3:160638505 G/A cg03342759 chr3:160939853 NMD3 0.44 8.76 0.33 1.74e-17 Morning vs. evening chronotype; BRCA cis rs2762353 0.718 rs1747550 chr6:25851533 A/G cg03264133 chr6:25882463 NA -0.55 -12.61 -0.45 1.01e-32 Blood metabolite levels; BRCA cis rs2032447 0.832 rs6922788 chr6:26052291 C/T cg03517284 chr6:25882590 NA -0.46 -9.64 -0.36 1.28e-20 Intelligence (multi-trait analysis); BRCA cis rs35000415 0.506 rs34288126 chr7:128735438 G/A cg02365945 chr7:128766374 LOC407835 -0.57 -8.34 -0.31 4.48e-16 Systemic lupus erythematosus; BRCA cis rs9560113 1.000 rs9560110 chr13:112181233 C/T cg10483660 chr13:112241077 NA 0.32 7.98 0.3 6.63e-15 Menarche (age at onset); BRCA cis rs7103648 0.742 rs34937994 chr11:47389638 C/T cg03711944 chr11:47377212 SPI1 -0.49 -12.58 -0.45 1.33e-32 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs8058578 0.945 rs8058961 chr16:30809063 G/A cg02466173 chr16:30829666 NA -0.52 -11.08 -0.4 3.13e-26 Multiple myeloma; BRCA trans rs7618501 0.633 rs12496973 chr3:50002245 T/C cg21659725 chr3:3221576 CRBN 0.46 11.67 0.42 1.12e-28 Intelligence (multi-trait analysis); BRCA cis rs7385804 0.761 rs1734910 chr7:100309544 A/G cg20848291 chr7:100343083 ZAN 0.37 8.32 0.31 5.39e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA trans rs9291683 0.588 rs13133766 chr4:10019732 C/T cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.3e-16 Bone mineral density; BRCA cis rs2635047 0.806 rs9962602 chr18:44599057 G/A cg19077165 chr18:44547161 KATNAL2 -0.49 -10.15 -0.37 1.57e-22 Educational attainment; BRCA cis rs4363385 0.818 rs6587719 chr1:152993409 G/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.86 -0.33 7.61e-18 Inflammatory skin disease; BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg03188948 chr7:1209495 NA 0.68 11.13 0.4 1.94e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg18404041 chr3:52824283 ITIH1 -0.44 -13.02 -0.46 1.49e-34 Bipolar disorder; BRCA cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg08999081 chr20:33150536 PIGU 0.47 13.15 0.46 3.96e-35 Glomerular filtration rate (creatinine); BRCA cis rs6450176 0.909 rs7732139 chr5:53292017 G/A ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.11 -0.49 1.51e-39 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7586879 0.593 rs10200566 chr2:25130462 G/T cg01884057 chr2:25150051 NA -0.35 -8.61 -0.32 5.85e-17 Body mass index; BRCA cis rs2839186 0.732 rs8131458 chr21:47694712 G/A cg12379764 chr21:47803548 PCNT -0.42 -8.59 -0.32 6.58e-17 Testicular germ cell tumor; BRCA cis rs17253792 0.822 rs78386830 chr14:56069224 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA cis rs6484504 0.576 rs158139 chr11:31216076 C/T cg26647111 chr11:31128758 NA -0.44 -9.67 -0.36 9.59e-21 Red blood cell count; BRCA cis rs9818758 0.607 rs13087930 chr3:48961726 A/G cg00383909 chr3:49044727 WDR6 0.97 15.54 0.52 1.9e-46 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs17601876 0.545 rs4775936 chr15:51536022 A/G cg19946085 chr15:51559439 CYP19A1 0.3 8.12 0.31 2.48e-15 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7593730 0.636 rs10181181 chr2:161087411 C/T cg22609984 chr2:161126801 NA -0.39 -8.5 -0.32 1.36e-16 Type 2 diabetes; BRCA cis rs870825 0.616 rs4386643 chr4:185624281 A/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs290268 1.000 rs290268 chr9:93552450 A/G cg02608019 chr9:93564028 SYK 0.54 11.83 0.42 2.45e-29 Platelet count; BRCA cis rs1862618 1.000 rs1862618 chr5:56096315 C/G cg24549020 chr5:56110836 MAP3K1 0.61 12.43 0.44 6.56e-32 Initial pursuit acceleration; BRCA cis rs4927850 0.881 rs7624638 chr3:195748729 C/T cg01181863 chr3:195395398 SDHAP2 -0.46 -8.16 -0.31 1.83e-15 Pancreatic cancer; BRCA cis rs4689592 0.503 rs59640165 chr4:7051661 G/A cg19539972 chr4:7069911 GRPEL1 -0.62 -11.53 -0.41 4.67e-28 Monocyte percentage of white cells; BRCA cis rs7552404 0.731 rs10732723 chr1:76392437 C/T cg10523679 chr1:76189770 ACADM -0.55 -10.03 -0.37 4.19e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg03934865 chr2:198174659 NA -0.44 -9.67 -0.36 9.81e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6582630 0.576 rs2222345 chr12:38356020 G/A cg26384229 chr12:38710491 ALG10B -0.42 -9.85 -0.36 2.1e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs2625529 0.668 rs35206011 chr15:72539494 T/C cg16672083 chr15:72433130 SENP8 -0.83 -17.54 -0.57 1.69e-56 Red blood cell count; BRCA cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg11663144 chr21:46675770 NA -0.56 -13.1 -0.46 6.42e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6840360 0.571 rs4696274 chr4:152528478 C/A cg22705602 chr4:152727874 NA -0.32 -8.14 -0.31 2.04e-15 Intelligence (multi-trait analysis); BRCA trans rs9329221 0.698 rs35388602 chr8:10259188 T/C cg15556689 chr8:8085844 FLJ10661 0.33 8.01 0.3 5.31e-15 Neuroticism; BRCA cis rs8062405 0.690 rs762634 chr16:28603335 T/C cg16576597 chr16:28551801 NUPR1 0.34 8.63 0.32 4.95e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs17685 0.753 rs2868203 chr7:75680026 G/A cg19862616 chr7:65841803 NCRNA00174 -0.85 -28.12 -0.74 7.91e-114 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.61 -12.73 -0.45 3e-33 Lymphocyte counts; BRCA cis rs3784262 0.669 rs4646623 chr15:58257123 T/G cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.32 -0.38 3.46e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs7939886 0.920 rs58405266 chr11:55863225 G/A cg15704280 chr7:45808275 SEPT13 0.6 7.86 0.3 1.58e-14 Myopia (pathological); BRCA cis rs8180040 1.000 rs11130127 chr3:47398793 C/G cg27129171 chr3:47204927 SETD2 -0.69 -16.55 -0.55 1.83e-51 Colorectal cancer; BRCA cis rs7524258 0.901 rs11120884 chr1:7305361 C/A cg07173049 chr1:7289937 CAMTA1 0.41 9.96 0.37 8.24e-22 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs6831352 0.819 rs13832 chr4:99993075 C/A cg12011299 chr4:100065546 ADH4 0.36 9.0 0.34 2.49e-18 Alcohol dependence; BRCA cis rs6543140 0.964 rs1523205 chr2:103070176 G/T cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs1005277 0.540 rs1814077 chr10:37992018 G/C cg00409905 chr10:38381863 ZNF37A -0.47 -10.07 -0.37 2.99e-22 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.580 rs4587214 chr6:8454119 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg04553112 chr3:125709451 NA -0.58 -9.24 -0.34 3.73e-19 Blood pressure (smoking interaction); BRCA cis rs7582180 0.817 rs1437967 chr2:100929072 C/G cg14675211 chr2:100938903 LONRF2 0.47 10.13 0.37 1.81e-22 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg22920501 chr2:26401640 FAM59B 0.91 13.96 0.48 7.9e-39 Gut microbiome composition (summer); BRCA cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg24531977 chr5:56204891 C5orf35 0.86 17.41 0.57 7.53e-56 Initial pursuit acceleration; BRCA cis rs738322 0.600 rs6001030 chr22:38555904 T/G cg25457927 chr22:38595422 NA -0.34 -11.72 -0.42 7.44e-29 Cutaneous nevi; BRCA cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg06550200 chr5:1325588 CLPTM1L -0.66 -14.34 -0.49 1.2e-40 Lung cancer; BRCA cis rs35110281 0.607 rs4819212 chr21:44977455 G/A cg21573476 chr21:45109991 RRP1B -0.33 -8.44 -0.32 2.16e-16 Mean corpuscular volume; BRCA cis rs10752881 0.935 rs10797834 chr1:183048749 T/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.95 0.56 1.78e-53 Colorectal cancer; BRCA cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg15212455 chr7:39170539 POU6F2 0.45 9.9 0.36 1.34e-21 IgG glycosylation; BRCA cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg17971929 chr21:40555470 PSMG1 0.62 14.43 0.5 4.63e-41 Cognitive function; BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg03188948 chr7:1209495 NA 0.91 14.34 0.49 1.21e-40 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6809651 0.524 rs12638263 chr3:185795855 A/C cg00760338 chr3:185826511 ETV5 -0.42 -8.06 -0.3 3.71e-15 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg23711669 chr6:146136114 FBXO30 -0.7 -13.88 -0.48 1.77e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs1336900 0.544 rs10888386 chr1:150611957 A/G cg04414720 chr1:150670196 GOLPH3L -0.37 -8.14 -0.31 2.1e-15 Blood protein levels; BRCA cis rs4363385 0.693 rs6668311 chr1:152964586 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.43 -0.35 7.39e-20 Inflammatory skin disease; BRCA trans rs6952808 0.500 rs3800902 chr7:2144378 C/T cg04565464 chr8:145669602 NFKBIL2 0.43 9.82 0.36 2.64e-21 Bipolar disorder and schizophrenia; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg22907277 chr7:1156413 C7orf50 0.59 9.19 0.34 5.33e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6684428 0.706 rs61774839 chr1:56336609 G/A cg11651538 chr1:56320950 NA -0.49 -8.36 -0.31 3.81e-16 Airflow obstruction; BRCA cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg25110423 chr6:41068646 NFYA;LOC221442 0.35 8.05 0.3 4.06e-15 Alzheimer's disease (late onset); BRCA cis rs7618501 0.521 rs6774354 chr3:49961780 G/A cg24110177 chr3:50126178 RBM5 -0.53 -15.92 -0.53 2.75e-48 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg02574844 chr11:5959923 NA -0.43 -8.5 -0.32 1.37e-16 DNA methylation (variation); BRCA cis rs3815700 1.000 rs8109768 chr19:33095463 A/G cg02997394 chr19:33096574 ANKRD27 0.69 11.47 0.41 7.98e-28 Eosinophilic esophagitis; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg09033563 chr22:24373618 LOC391322 -0.58 -12.55 -0.44 1.82e-32 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6750047 0.549 rs151096 chr2:38316571 A/C cg07380506 chr2:38303506 CYP1B1 -0.41 -9.35 -0.35 1.44e-19 Cutaneous malignant melanoma;Melanoma; BRCA trans rs11098499 0.863 rs10013305 chr4:120450424 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs6089584 0.927 rs11697597 chr20:60584748 C/T cg06108461 chr20:60628389 TAF4 -0.83 -17.59 -0.57 9.2e-57 Body mass index; BRCA cis rs6484504 0.532 rs10835756 chr11:31267622 C/T cg26647111 chr11:31128758 NA -0.45 -9.74 -0.36 5.44e-21 Red blood cell count; BRCA cis rs921968 0.541 rs578450 chr2:219401237 C/T cg02176678 chr2:219576539 TTLL4 0.46 11.92 0.43 9.84e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs10504229 0.906 rs7842855 chr8:58167718 G/C cg24829409 chr8:58192753 C8orf71 -0.55 -11.6 -0.42 2.34e-28 Developmental language disorder (linguistic errors); BRCA cis rs12971120 0.891 rs11151961 chr18:72177340 C/T cg25817165 chr18:72167213 CNDP2 -0.72 -12.73 -0.45 3.16e-33 Refractive error; BRCA cis rs9463078 0.809 rs6899845 chr6:45043352 A/C cg25276700 chr6:44698697 NA -0.39 -9.07 -0.34 1.43e-18 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs250677 0.652 rs250675 chr5:148438565 A/C cg18129178 chr5:148520854 ABLIM3 0.65 12.93 0.46 3.88e-34 Breast cancer; BRCA cis rs4363385 0.818 rs4284210 chr1:152985711 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.45 -0.32 1.91e-16 Inflammatory skin disease; BRCA cis rs9291683 0.588 rs4697705 chr4:10108127 G/A cg00071950 chr4:10020882 SLC2A9 -0.47 -11.11 -0.4 2.48e-26 Bone mineral density; BRCA cis rs2153535 0.562 rs9379211 chr6:8463927 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs561341 1.000 rs501957 chr17:30314504 C/T cg27661571 chr11:113659931 NA -0.64 -9.97 -0.37 7.66e-22 Hip circumference adjusted for BMI; BRCA cis rs3008870 0.755 rs1121824 chr1:67475616 C/A cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.81 0.48 3.77e-38 Lymphocyte percentage of white cells; BRCA cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg10523679 chr1:76189770 ACADM 0.6 10.95 0.4 1.06e-25 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2762353 0.779 rs9393672 chr6:25842605 T/G cg03517284 chr6:25882590 NA -0.4 -9.19 -0.34 5.27e-19 Blood metabolite levels; BRCA cis rs12410462 0.582 rs2872251 chr1:227647723 G/A cg04117972 chr1:227635322 NA 0.49 8.82 0.33 1.09e-17 Major depressive disorder; BRCA cis rs1005277 0.522 rs1208684 chr10:38093936 G/A cg25427524 chr10:38739819 LOC399744 -0.65 -15.75 -0.53 1.83e-47 Extrinsic epigenetic age acceleration; BRCA cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg26408565 chr15:76604113 ETFA -0.48 -10.39 -0.38 1.73e-23 Blood metabolite levels; BRCA cis rs1577917 0.876 rs1582127 chr6:86697204 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.03 -0.43 3.28e-30 Response to antipsychotic treatment; BRCA trans rs35110281 0.805 rs8131005 chr21:45041954 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.15 0.31 1.98e-15 Mean corpuscular volume; BRCA cis rs875971 0.964 rs2277911 chr7:65958625 T/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg04455712 chr21:45112962 RRP1B -0.39 -10.01 -0.37 5.02e-22 Mean corpuscular volume; BRCA cis rs12540874 0.728 rs3807563 chr7:50566390 C/T cg18232548 chr7:50535776 DDC -0.53 -12.29 -0.44 2.59e-31 Systemic sclerosis; BRCA cis rs11971779 0.585 rs3922848 chr7:139046210 T/C cg07862535 chr7:139043722 LUC7L2 0.38 10.28 0.38 4.63e-23 Diisocyanate-induced asthma; BRCA cis rs2841277 0.708 rs11623422 chr14:105407031 A/G cg14403583 chr14:105418241 AHNAK2 -0.38 -8.97 -0.33 3.29e-18 Rheumatoid arthritis; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg25036284 chr2:26402008 FAM59B 0.9 15.81 0.53 9.61e-48 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs11726604 chr4:99000969 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.44 -0.41 1.04e-27 Schizophrenia; BRCA cis rs35110281 0.667 rs4819293 chr21:45125863 A/G cg01579765 chr21:45077557 HSF2BP -0.39 -9.73 -0.36 5.86e-21 Mean corpuscular volume; BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg05552183 chr6:42928497 GNMT 0.69 15.72 0.53 2.53e-47 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1862618 0.853 rs1559282 chr5:56099375 T/A cg22800045 chr5:56110881 MAP3K1 0.56 10.52 0.38 5.82e-24 Initial pursuit acceleration; BRCA cis rs908922 0.676 rs6674451 chr1:152531054 C/T cg20991723 chr1:152506922 NA 0.36 8.13 0.31 2.24e-15 Hair morphology; BRCA cis rs10484885 0.878 rs72921937 chr6:90579863 T/G cg13799429 chr6:90582589 CASP8AP2 -0.76 -9.46 -0.35 5.86e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs8141529 0.719 rs5762880 chr22:29287816 T/G cg15103426 chr22:29168792 CCDC117 0.51 12.13 0.43 1.26e-30 Lymphocyte counts; BRCA cis rs4319547 0.656 rs9788145 chr12:122899522 C/T cg05707623 chr12:122985044 ZCCHC8 -0.44 -8.79 -0.33 1.36e-17 Body mass index; BRCA cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg12365402 chr11:9010492 NRIP3 -0.39 -9.05 -0.34 1.69e-18 Hemoglobin concentration; BRCA cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg05347473 chr6:146136440 FBXO30 0.39 7.85 0.3 1.76e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.756 rs13356762 chr5:56110992 G/T cg12311346 chr5:56204834 C5orf35 -0.79 -16.15 -0.54 1.8e-49 Initial pursuit acceleration; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg15112475 chr7:1198522 ZFAND2A -0.57 -13.92 -0.48 1.12e-38 Longevity;Endometriosis; BRCA cis rs4631830 0.657 rs2611502 chr10:51500301 A/G cg20129853 chr10:51489980 NA -0.33 -8.57 -0.32 7.83e-17 Prostate-specific antigen levels; BRCA trans rs629535 0.814 rs654452 chr8:70074344 C/G cg21567404 chr3:27674614 NA 1.01 21.24 0.64 3.84e-76 Dupuytren's disease; BRCA cis rs7520050 0.898 rs785502 chr1:46581444 T/C cg24296786 chr1:45957014 TESK2 0.41 9.12 0.34 9.94e-19 Red blood cell count;Reticulocyte count; BRCA cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg22535103 chr8:58192502 C8orf71 0.45 8.93 0.33 4.35e-18 Developmental language disorder (linguistic errors); BRCA cis rs501916 0.833 rs10519143 chr15:48055567 T/G cg16110827 chr15:48056943 SEMA6D -0.44 -9.21 -0.34 4.48e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs752010 0.871 rs10890149 chr1:42092791 T/A cg06885757 chr1:42089581 HIVEP3 0.24 8.71 0.33 2.69e-17 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg21775979 chr11:780331 NA 0.4 9.0 0.34 2.49e-18 Breast cancer; BRCA trans rs561341 1.000 rs55736640 chr17:30333848 G/A cg20587970 chr11:113659929 NA -1.36 -23.91 -0.69 9.46e-91 Hip circumference adjusted for BMI; BRCA cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg27398817 chr8:82754497 SNX16 -0.37 -8.0 -0.3 5.93e-15 Diastolic blood pressure; BRCA cis rs35306767 0.761 rs11253558 chr10:1043983 T/C cg10556349 chr10:835070 NA 0.59 8.09 0.3 3.05e-15 Eosinophil percentage of granulocytes; BRCA cis rs919433 0.589 rs7601800 chr2:198395099 T/C cg00792783 chr2:198669748 PLCL1 0.36 8.36 0.31 3.79e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg26597838 chr10:835615 NA 0.84 15.34 0.52 1.85e-45 Eosinophil percentage of granulocytes; BRCA cis rs1355223 0.583 rs2915178 chr11:34878051 C/T cg11058730 chr11:34937778 PDHX;APIP 0.71 16.58 0.55 1.22e-51 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.53 0.38 4.91e-24 Motion sickness; BRCA cis rs977987 0.806 rs8050059 chr16:75388731 C/T cg03315344 chr16:75512273 CHST6 0.52 12.1 0.43 1.71e-30 Dupuytren's disease; BRCA cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs7927592 0.913 rs55883802 chr11:68278829 G/A cg20283391 chr11:68216788 NA -0.48 -9.31 -0.35 2.06e-19 Total body bone mineral density; BRCA cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.31e-54 Bladder cancer; BRCA cis rs1003719 0.667 rs3753073 chr21:38466615 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.53 11.32 0.41 3.27e-27 Eye color traits; BRCA cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg00071950 chr4:10020882 SLC2A9 0.65 16.24 0.54 6.46e-50 Bone mineral density; BRCA cis rs7617773 0.817 rs17786132 chr3:48249420 C/G cg11946769 chr3:48343235 NME6 0.68 14.01 0.48 4.49e-39 Coronary artery disease; BRCA cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg00071950 chr4:10020882 SLC2A9 0.55 13.19 0.46 2.62e-35 Bone mineral density; BRCA cis rs365132 0.840 rs58400555 chr5:176454081 A/T cg16309518 chr5:176445507 NA -0.51 -12.95 -0.46 3.19e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs35146811 0.555 rs1981550 chr7:99541952 G/A cg22906224 chr7:99728672 NA 0.43 7.93 0.3 9.58e-15 Coronary artery disease; BRCA cis rs7474896 0.583 rs1735621 chr10:38167723 G/T cg25427524 chr10:38739819 LOC399744 0.58 10.64 0.39 1.85e-24 Obesity (extreme); BRCA cis rs6684514 0.922 rs12128785 chr1:156269389 A/G cg16558208 chr1:156270281 VHLL 0.35 8.18 0.31 1.57e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7666738 0.830 rs4441757 chr4:98927059 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 9.79e-41 Motion sickness; BRCA cis rs634534 0.622 rs624273 chr11:65712413 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.39 9.27 0.34 2.79e-19 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7914558 0.966 rs1591915 chr10:104646849 C/T cg04362960 chr10:104952993 NT5C2 0.42 10.14 0.37 1.67e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs1997103 1.000 rs4947500 chr7:55407270 C/A cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg06453172 chr10:134556979 INPP5A -0.58 -12.05 -0.43 2.87e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg09184832 chr6:79620586 NA -0.43 -8.45 -0.32 2.03e-16 Intelligence (multi-trait analysis); BRCA cis rs17401966 1.000 rs17401924 chr1:10384439 A/G cg03954927 chr1:10346856 KIF1B 0.46 13.05 0.46 1.1e-34 Hepatocellular carcinoma; BRCA cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg07917127 chr4:99064746 C4orf37 0.44 8.06 0.3 3.71e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs4596713 0.568 rs10122932 chr9:71746053 C/G cg16512924 chr15:28394682 HERC2 0.39 9.51 0.35 3.76e-20 Headache; BRCA cis rs778371 0.522 rs6704768 chr2:233592501 C/T cg08000102 chr2:233561755 GIGYF2 0.72 17.71 0.57 2.06e-57 Schizophrenia; BRCA cis rs9457247 0.765 rs6904946 chr6:167433948 C/T cg23791538 chr6:167370224 RNASET2 0.37 8.87 0.33 7.17e-18 Crohn's disease; BRCA cis rs7178424 0.811 rs12910541 chr15:62248911 C/T cg00456672 chr15:62358751 C2CD4A 0.36 8.77 0.33 1.56e-17 Height; BRCA cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg26818010 chr10:134567672 INPP5A 0.7 14.83 0.51 5.56e-43 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3784262 0.669 rs4646635 chr15:58252277 T/C cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.24 -0.38 6.66e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg06634786 chr22:41940651 POLR3H -0.5 -8.2 -0.31 1.33e-15 Vitiligo; BRCA cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.27 0.49 2.52e-40 Motion sickness; BRCA cis rs1997103 1.000 rs2009441 chr7:55405989 A/G cg17469321 chr7:55412551 NA 0.5 9.53 0.35 3.24e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg23978390 chr7:1156363 C7orf50 0.44 10.1 0.37 2.36e-22 Longevity;Endometriosis; BRCA cis rs9733 0.596 rs2867301 chr1:150653795 C/T cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs3740540 0.761 rs34496154 chr10:126284336 C/T cg04949429 chr10:126290192 LHPP -0.41 -9.01 -0.34 2.28e-18 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs9837602 1.000 rs62285478 chr3:99822135 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.3e-26 Breast cancer; BRCA cis rs6088580 0.524 rs6087612 chr20:33230822 T/G cg08999081 chr20:33150536 PIGU -0.33 -8.71 -0.33 2.57e-17 Glomerular filtration rate (creatinine); BRCA cis rs1153858 1.000 rs61365925 chr15:45650311 T/C cg21132104 chr15:45694354 SPATA5L1 0.72 16.11 0.54 3.09e-49 Homoarginine levels; BRCA cis rs12142240 0.698 rs68012736 chr1:46839510 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.44 -0.35 7.1e-20 Menopause (age at onset); BRCA cis rs7824557 0.606 rs2736264 chr8:11186639 G/C cg21775007 chr8:11205619 TDH 0.72 17.31 0.56 2.48e-55 Retinal vascular caliber; BRCA cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11644478 chr21:40555479 PSMG1 0.84 19.09 0.6 1.29e-64 Cognitive function; BRCA cis rs11608355 0.705 rs4766601 chr12:109890080 C/G cg05360138 chr12:110035743 NA 0.44 8.49 0.32 1.5e-16 Neuroticism; BRCA cis rs1712517 0.588 rs12220267 chr10:105075712 C/T cg04362960 chr10:104952993 NT5C2 -0.39 -7.85 -0.3 1.71e-14 Migraine; BRCA cis rs2839186 0.934 rs13046494 chr21:47707430 A/C cg12379764 chr21:47803548 PCNT -0.37 -7.86 -0.3 1.61e-14 Testicular germ cell tumor; BRCA trans rs9325144 0.650 rs6582624 chr12:38733475 A/T cg23762105 chr12:34175262 ALG10 0.36 8.25 0.31 9.3e-16 Morning vs. evening chronotype; BRCA cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg11764359 chr7:65958608 NA -0.73 -16.1 -0.54 3.49e-49 Aortic root size; BRCA cis rs2652834 1.000 rs2652833 chr15:63396885 C/A cg05507819 chr15:63340323 TPM1 0.44 8.08 0.3 3.16e-15 HDL cholesterol; BRCA cis rs3760982 0.585 rs8109478 chr19:44298256 C/T cg11993925 chr19:44307056 LYPD5 0.37 8.89 0.33 6.39e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs7072216 0.727 rs10748728 chr10:100171198 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs3733585 0.624 rs76574510 chr4:9953252 T/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.31 -0.38 3.71e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11644478 chr21:40555479 PSMG1 0.83 19.1 0.6 1.15e-64 Cognitive function; BRCA cis rs17376456 0.569 rs17083377 chr5:93164870 C/G cg25358565 chr5:93447407 FAM172A 0.66 11.49 0.41 6.43e-28 Diabetic retinopathy; BRCA cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs9814567 0.896 rs4435682 chr3:134344182 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.27 0.31 8.01e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs5771242 0.518 rs6010216 chr22:50679471 C/T cg08875078 chr22:50639485 SELO 0.38 7.84 0.3 1.85e-14 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); BRCA cis rs13118159 0.801 rs7690727 chr4:1340811 C/A cg01939980 chr4:1354348 KIAA1530 0.3 8.39 0.31 3.17e-16 Longevity; BRCA cis rs6565180 1.000 rs6565180 chr16:30361341 G/T cg17640201 chr16:30407289 ZNF48 -0.78 -19.86 -0.62 1.02e-68 Tonsillectomy; BRCA cis rs4820539 1.000 rs885965 chr22:23461425 A/G cg14186256 chr22:23484241 RTDR1 0.72 20.54 0.63 2.23e-72 Bone mineral density; BRCA cis rs1355223 0.583 rs2116085 chr11:34884001 C/A cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.33 -0.35 1.72e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg01579765 chr21:45077557 HSF2BP -0.38 -10.07 -0.37 3.18e-22 Mean corpuscular volume; BRCA cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg25358565 chr5:93447407 FAM172A 1.03 16.07 0.54 4.56e-49 Diabetic retinopathy; BRCA cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg06640241 chr16:89574553 SPG7 0.58 12.77 0.45 2.02e-33 Multiple myeloma (IgH translocation); BRCA cis rs2019137 0.560 rs7421852 chr2:113990261 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.58 12.16 0.43 9.56e-31 Lymphocyte counts; BRCA cis rs7666738 0.830 rs6831219 chr4:98993576 C/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs514406 0.621 rs881198 chr1:53196440 C/T cg08859206 chr1:53392774 SCP2 0.41 8.37 0.31 3.73e-16 Monocyte count; BRCA cis rs801193 1.000 rs17566701 chr7:66193183 T/C cg11764359 chr7:65958608 NA 0.62 13.41 0.47 2.63e-36 Aortic root size; BRCA cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg24692254 chr21:30365293 RNF160 -0.68 -18.76 -0.6 7.17e-63 Dental caries; BRCA cis rs11920090 0.858 rs73167792 chr3:170690375 A/C cg09710316 chr3:170744871 SLC2A2 0.51 8.2 0.31 1.35e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs1707322 0.752 rs11211146 chr1:46109794 T/C cg03146154 chr1:46216737 IPP 0.52 11.63 0.42 1.68e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs933688 1.000 rs10059163 chr5:90742444 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 21.17 0.64 8.76e-76 Smoking behavior; BRCA cis rs1005277 0.579 rs2505248 chr10:38459097 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -16.49 -0.55 3.7e-51 Extrinsic epigenetic age acceleration; BRCA cis rs9649465 0.967 rs7809453 chr7:123301940 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.46e-16 Migraine; BRCA cis rs1348850 0.526 rs935426 chr2:178369433 T/C cg27490568 chr2:178487706 NA 0.5 8.4 0.32 2.91e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs783540 0.933 rs2567636 chr15:83263428 C/T cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.16 -0.31 1.83e-15 Schizophrenia; BRCA cis rs30380 0.632 rs26495 chr5:96137840 A/G cg16492584 chr5:96139282 ERAP1 -0.47 -11.09 -0.4 2.87e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg21535247 chr6:8435926 SLC35B3 0.41 9.48 0.35 5.09e-20 Motion sickness; BRCA cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.8 -0.36 3.12e-21 Alcohol dependence; BRCA cis rs6426558 0.537 rs498020 chr1:227304180 G/A cg10327440 chr1:227177885 CDC42BPA 0.47 9.27 0.34 2.83e-19 Neutrophil percentage of white cells; BRCA cis rs7737355 0.947 rs2021774 chr5:130920831 G/A cg06307176 chr5:131281290 NA 0.52 10.6 0.39 2.81e-24 Life satisfaction; BRCA trans rs11098499 0.863 rs10009626 chr4:120470005 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs2204008 0.777 rs2387813 chr12:38382091 A/C cg26384229 chr12:38710491 ALG10B 0.69 16.25 0.54 5.7e-50 Bladder cancer; BRCA cis rs2742234 0.590 rs2293020 chr10:43692887 A/G cg15436174 chr10:43711423 RASGEF1A 0.51 10.65 0.39 1.64e-24 Hirschsprung disease; BRCA cis rs9811920 0.609 rs793467 chr3:99539664 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 -0.37 -8.42 -0.32 2.47e-16 Axial length; BRCA cis rs9467773 0.620 rs9295701 chr6:26627508 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.15e-42 Intelligence (multi-trait analysis); BRCA cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg25654072 chr17:61904446 PSMC5;FTSJ3 -0.32 -8.41 -0.32 2.63e-16 Height; BRCA cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg27165867 chr14:105738592 BRF1 -0.39 -9.02 -0.34 2.18e-18 Mean platelet volume;Platelet distribution width; BRCA cis rs6842047 0.706 rs4862667 chr4:187136416 A/G cg09526685 chr4:187126073 CYP4V2 0.99 11.31 0.41 3.75e-27 Blood protein levels; BRCA cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg00074818 chr8:8560427 CLDN23 0.38 8.31 0.31 5.64e-16 Obesity-related traits; BRCA cis rs752010 0.714 rs7552928 chr1:42086664 C/T cg06885757 chr1:42089581 HIVEP3 0.3 10.72 0.39 8.97e-25 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9815354 0.951 rs9850310 chr3:41891098 T/C cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 4.05e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6763687 0.964 rs1563436 chr3:171786094 C/T cg16233210 chr3:171778391 FNDC3B 0.49 11.7 0.42 8.8e-29 Red cell distribution width; BRCA cis rs7824557 0.767 rs6991606 chr8:11176159 G/A cg21775007 chr8:11205619 TDH 0.64 12.5 0.44 3.27e-32 Retinal vascular caliber; BRCA cis rs1448094 0.512 rs6539933 chr12:86247611 T/C cg19622623 chr12:86230825 RASSF9 -0.34 -9.6 -0.36 1.79e-20 Major depressive disorder; BRCA cis rs4363385 0.791 rs3120744 chr1:153010330 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.17 -0.34 6.49e-19 Inflammatory skin disease; BRCA cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg27398817 chr8:82754497 SNX16 0.38 8.71 0.33 2.64e-17 Diastolic blood pressure; BRCA cis rs2276314 1.000 rs56050783 chr18:33553791 A/G cg19628046 chr18:33552617 C18orf21 0.6 12.38 0.44 1.01e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs11105298 0.891 rs3741899 chr12:89933931 G/A cg00757033 chr12:89920650 WDR51B 0.51 10.42 0.38 1.34e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2075371 0.933 rs2244548 chr7:133986234 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.95e-23 Mean platelet volume; BRCA cis rs7095944 0.584 rs11245347 chr10:126427037 G/T cg08799069 chr10:126477246 METTL10 -0.41 -10.19 -0.37 1.1e-22 Asthma; BRCA cis rs1008375 0.898 rs61047804 chr4:17593965 G/A cg15017067 chr4:17643749 FAM184B 0.34 10.35 0.38 2.6e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9487051 0.734 rs56214745 chr6:109536748 G/T cg21918786 chr6:109611834 NA -0.35 -9.22 -0.34 4.22e-19 Reticulocyte fraction of red cells; BRCA cis rs30380 0.632 rs26500 chr5:96133712 A/C cg16492584 chr5:96139282 ERAP1 -0.46 -10.91 -0.4 1.57e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs3733585 0.654 rs4447863 chr4:9938969 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -13.27 -0.46 1.09e-35 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7246657 0.943 rs4801759 chr19:37954985 G/A cg23950597 chr19:37808831 NA -0.74 -13.09 -0.46 7.77e-35 Coronary artery calcification; BRCA cis rs4363385 0.818 rs11205174 chr1:153001230 C/T cg25856811 chr1:152973957 SPRR3 0.32 8.27 0.31 7.64e-16 Inflammatory skin disease; BRCA cis rs2832077 0.506 rs2832088 chr21:30158620 G/A cg08807101 chr21:30365312 RNF160 -0.4 -8.22 -0.31 1.12e-15 Cognitive test performance; BRCA cis rs7666738 0.546 rs10461174 chr4:98698293 G/A cg05340658 chr4:99064831 C4orf37 0.58 11.11 0.4 2.33e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs7918232 0.941 rs6482598 chr10:27426375 T/C cg14240646 chr10:27532245 ACBD5 -0.62 -9.58 -0.35 2.13e-20 Breast cancer; BRCA cis rs11229555 0.645 rs34054511 chr11:58204943 A/C cg15696309 chr11:58395628 NA -0.45 -9.65 -0.36 1.17e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs3796619 1.000 rs2290409 chr4:1067249 C/T cg27284194 chr4:1044797 NA -0.42 -8.92 -0.33 4.96e-18 Recombination rate (males); BRCA cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10493773 0.775 rs12738010 chr1:86102575 A/C cg17807903 chr1:86174739 ZNHIT6 0.45 10.34 0.38 2.77e-23 Urate levels in overweight individuals; BRCA cis rs8180040 0.764 rs12630534 chr3:47001043 T/C cg02527881 chr3:46936655 PTH1R -0.38 -9.45 -0.35 6.25e-20 Colorectal cancer; BRCA trans rs3733585 0.699 rs7686538 chr4:9948077 C/T cg26043149 chr18:55253948 FECH -0.37 -8.05 -0.3 3.94e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs9329221 0.710 rs11779205 chr8:10260100 C/T cg15556689 chr8:8085844 FLJ10661 0.34 8.13 0.31 2.28e-15 Neuroticism; BRCA trans rs61931739 0.817 rs10743842 chr12:34306859 C/T cg26384229 chr12:38710491 ALG10B 0.43 10.38 0.38 2.0500000000000001e-23 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.93 -0.3 9.91e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs586533 0.881 rs1790266 chr11:99512424 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.86 0.3 1.59e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs7584330 0.868 rs13386290 chr2:238393136 G/C cg14458575 chr2:238380390 NA 0.53 11.76 0.42 4.93e-29 Prostate cancer; BRCA cis rs2625529 0.775 rs4777489 chr15:72430434 C/T cg16672083 chr15:72433130 SENP8 0.83 17.83 0.58 4.8e-58 Red blood cell count; BRCA cis rs13191362 1.000 rs34138336 chr6:163144929 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.09 0.37 2.64e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2629540 0.847 rs11245342 chr10:126414084 C/T cg08799069 chr10:126477246 METTL10 0.48 9.47 0.35 5.55e-20 Cocaine dependence; BRCA cis rs9811920 0.609 rs4244711 chr3:99657205 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.86 -0.3 1.65e-14 Axial length; BRCA cis rs7772486 0.764 rs7745696 chr6:146162829 T/C cg05347473 chr6:146136440 FBXO30 0.39 8.12 0.31 2.44e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.02 0.3 4.93e-15 Corneal astigmatism; BRCA trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg11707556 chr5:10655725 ANKRD33B 0.39 9.38 0.35 1.13e-19 Coronary artery disease; BRCA cis rs1707322 0.721 rs6429575 chr1:46134216 G/C cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs889312 0.500 rs3099460 chr5:56133748 G/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.38 -0.31 3.3e-16 Breast cancer;Breast cancer (early onset); BRCA cis rs2832191 0.692 rs8134627 chr21:30349069 C/T cg08807101 chr21:30365312 RNF160 -0.76 -20.09 -0.62 5.8e-70 Dental caries; BRCA cis rs2731664 0.819 rs449351 chr5:176872591 T/C cg23176889 chr5:176863531 GRK6 -0.6 -15.94 -0.53 2.09e-48 Intelligence (multi-trait analysis); BRCA cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg04990556 chr1:26633338 UBXN11 0.77 17.4 0.57 8.21e-56 Obesity-related traits; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 18.74 0.6 8.38e-63 Platelet count; BRCA cis rs12200560 0.505 rs60879781 chr6:97075466 A/T cg06623918 chr6:96969491 KIAA0776 0.53 12.83 0.45 1.14e-33 Coronary heart disease; BRCA cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg19196401 chr6:110721138 DDO 0.4 9.71 0.36 7.08e-21 Platelet distribution width; BRCA cis rs7580658 0.963 rs12479003 chr2:128118553 C/T cg09760422 chr2:128146352 NA -0.35 -7.85 -0.3 1.82e-14 Protein C levels; BRCA cis rs2033711 0.783 rs11671113 chr19:58958087 C/T cg13877915 chr19:58951672 ZNF132 0.46 10.85 0.39 2.81e-25 Uric acid clearance; BRCA cis rs11098499 0.604 rs2389886 chr4:120570422 C/T cg09307838 chr4:120376055 NA 0.59 11.08 0.4 3.21e-26 Corneal astigmatism; BRCA cis rs60871478 0.730 rs13222476 chr7:826630 T/C cg04727924 chr7:799746 HEATR2 -0.52 -9.26 -0.34 2.97e-19 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.5 0.57 2.57e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2425143 0.818 rs2378414 chr20:34534374 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.18 -0.31 1.59e-15 Blood protein levels; BRCA cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.75e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6459804 0.967 rs10233396 chr7:157512290 C/T cg05731713 chr7:157510257 PTPRN2 0.4 10.3 0.38 4.01e-23 Bipolar disorder and schizophrenia; BRCA cis rs34779708 0.966 rs4934539 chr10:35472199 A/G cg03585969 chr10:35415529 CREM 0.49 10.32 0.38 3.28e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg17971929 chr21:40555470 PSMG1 -0.63 -13.96 -0.48 7.69e-39 Cognitive function; BRCA cis rs1448094 0.549 rs4919770 chr12:86238050 G/T cg02569458 chr12:86230093 RASSF9 0.31 7.84 0.3 1.9e-14 Major depressive disorder; BRCA cis rs12760731 0.565 rs71628268 chr1:178151908 T/C cg00404053 chr1:178313656 RASAL2 0.71 7.97 0.3 7.29e-15 Obesity-related traits; BRCA cis rs7267979 1.000 rs2297496 chr20:25295787 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.76 -0.36 4.5e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11711311 0.955 rs9881563 chr3:113414031 C/T cg06805542 chr3:113465803 ATP6V1A;NAA50 0.41 8.94 0.33 4.24e-18 IgG glycosylation; BRCA trans rs3858145 0.588 rs78041174 chr10:70038771 G/A cg04882175 chr6:131122610 NA -0.36 -8.66 -0.32 3.91e-17 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs763121 0.853 rs5750673 chr22:39110124 G/A cg06544989 chr22:39130855 UNC84B 0.34 7.91 0.3 1.18e-14 Menopause (age at onset); BRCA cis rs4919694 0.615 rs78384860 chr10:105003019 G/T cg04362960 chr10:104952993 NT5C2 0.83 11.36 0.41 2.29e-27 Arsenic metabolism; BRCA cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.55e-66 Mean platelet volume; BRCA cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg21573476 chr21:45109991 RRP1B -0.35 -9.13 -0.34 8.69e-19 Mean corpuscular volume; BRCA cis rs6570726 0.846 rs870491 chr6:145933390 T/G cg23711669 chr6:146136114 FBXO30 0.71 17.07 0.56 4.4e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs11229555 0.957 rs10896796 chr11:58394256 A/G cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs8177253 0.665 rs9869535 chr3:133451581 G/A cg12373951 chr3:133503437 NA 0.34 8.11 0.31 2.68e-15 Iron status biomarkers; BRCA cis rs3749237 0.964 rs1799845 chr3:49847623 A/G cg07636037 chr3:49044803 WDR6 0.45 8.98 0.33 2.92e-18 Resting heart rate; BRCA cis rs7811142 1.000 rs6975729 chr7:100028187 C/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.06 0.34 1.52e-18 Platelet count; BRCA cis rs6840258 1.000 rs114701347 chr4:87965001 C/T cg08197287 chr4:87952173 AFF1 -0.45 -8.99 -0.34 2.68e-18 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs4766646 0.619 rs10850883 chr12:110292513 G/A cg01252219 chr12:110302105 GLTP 0.38 8.57 0.32 7.96e-17 Metabolite levels (MHPG); BRCA cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs739401 0.572 rs739400 chr11:3016520 G/A cg08508325 chr11:3079039 CARS -0.4 -14.35 -0.49 1.1e-40 Longevity; BRCA cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg06420487 chr17:61919686 SMARCD2 -0.4 -8.11 -0.31 2.57e-15 Height; BRCA cis rs6942756 0.747 rs691124 chr7:129098439 A/G cg02491457 chr7:128862824 NA -0.56 -11.62 -0.42 1.9e-28 White matter hyperintensity burden; BRCA cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg10433463 chr1:1889099 KIAA1751 -0.33 -8.82 -0.33 1.12e-17 Body mass index; BRCA trans rs8073060 0.544 rs8072676 chr17:33999517 C/T cg19694781 chr19:47549865 TMEM160 -1.02 -21.48 -0.65 1.9e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs3733585 0.673 rs4495037 chr4:9954050 C/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.53e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg24675658 chr1:53192096 ZYG11B -0.7 -16.61 -0.55 9.26e-52 Monocyte count; BRCA cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg11366901 chr6:160182831 ACAT2 0.81 15.88 0.53 4.15e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs67478160 0.583 rs12879612 chr14:104233618 T/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.02 -0.4 5.64e-26 Schizophrenia; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.74 -0.39 7.28e-25 Lymphocyte counts; BRCA cis rs6700896 0.931 rs4655584 chr1:66155515 T/G cg04111102 chr1:66153794 NA 0.34 8.47 0.32 1.68e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2075371 0.897 rs1646743 chr7:134003451 C/A cg02659138 chr7:134003124 SLC35B4 0.34 10.71 0.39 1.02e-24 Mean platelet volume; BRCA cis rs11792861 0.962 rs11789624 chr9:111796231 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 7.85 0.3 1.71e-14 Menarche (age at onset); BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs7267979 0.866 rs437635 chr20:25456888 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.85 0.33 8.73e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.28 0.31 7.11e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg05279229 chr7:1896384 MAD1L1 -0.39 -7.83 -0.3 1.99e-14 Bipolar disorder and schizophrenia; BRCA cis rs7617773 0.779 rs77957078 chr3:48331286 G/C cg11946769 chr3:48343235 NME6 0.67 13.87 0.48 2.01e-38 Coronary artery disease; BRCA cis rs7246657 0.722 rs11083432 chr19:38182633 A/G cg14683738 chr19:37701593 ZNF585B -0.49 -8.8 -0.33 1.23e-17 Coronary artery calcification; BRCA cis rs13256369 0.851 rs13255061 chr8:8563834 G/A cg17143192 chr8:8559678 CLDN23 0.57 11.08 0.4 3.3e-26 Obesity-related traits; BRCA cis rs17209837 0.607 rs2109505 chr7:87079406 T/A cg00919237 chr7:87102261 ABCB4 -0.5 -8.97 -0.33 3.17e-18 Gallbladder cancer; BRCA cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg14061069 chr19:46274453 DMPK -0.45 -11.29 -0.41 4.25e-27 Coronary artery disease; BRCA cis rs6484504 0.576 rs11031323 chr11:31245413 T/G cg26647111 chr11:31128758 NA -0.45 -9.72 -0.36 6.19e-21 Red blood cell count; BRCA cis rs11711311 1.000 rs2242108 chr3:113433903 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.68 0.39 1.25e-24 IgG glycosylation; BRCA cis rs1401999 0.606 rs7644687 chr3:183753353 A/G cg20387954 chr3:183756860 HTR3D 0.57 12.4 0.44 8.62e-32 Anterior chamber depth; BRCA cis rs7618915 0.547 rs11719685 chr3:52676065 C/T cg10802521 chr3:52805072 NEK4 -0.32 -7.99 -0.3 6.53e-15 Bipolar disorder; BRCA cis rs2032447 0.670 rs198848 chr6:26106325 A/G cg12310025 chr6:25882481 NA -0.4 -9.12 -0.34 9.94e-19 Intelligence (multi-trait analysis); BRCA cis rs4808199 0.948 rs968525 chr19:19459215 C/T cg03709012 chr19:19516395 GATAD2A 0.91 17.82 0.58 5.94e-58 Nonalcoholic fatty liver disease; BRCA cis rs17270561 0.636 rs77343532 chr6:25828828 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.31 0.38 3.84e-23 Iron status biomarkers; BRCA cis rs796364 0.806 rs203765 chr2:200903020 G/A cg23649088 chr2:200775458 C2orf69 -0.55 -7.86 -0.3 1.68e-14 Schizophrenia; BRCA cis rs1832871 0.538 rs6924801 chr6:158718805 A/G cg07215822 chr6:158701037 NA 0.5 10.35 0.38 2.49e-23 Height; BRCA cis rs2243480 0.901 rs778693 chr7:65872345 T/G cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs7666738 0.830 rs13124689 chr4:98961182 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4243830 0.850 rs4908911 chr1:6599523 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -16.07 -0.54 4.79e-49 Body mass index; BRCA cis rs3008870 0.959 rs4655658 chr1:67389608 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.07 0.64 2.94e-75 Lymphocyte percentage of white cells; BRCA cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg24642439 chr20:33292090 TP53INP2 -0.44 -8.68 -0.32 3.35e-17 Height; BRCA cis rs1635 0.826 rs115041649 chr6:28274653 G/C cg15743358 chr6:28303923 ZNF323 -0.73 -7.92 -0.3 1.06e-14 Schizophrenia; BRCA cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg13271783 chr10:134563150 INPP5A -0.51 -9.7 -0.36 7.73e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1577917 0.655 rs9359658 chr6:86305769 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 12.5 0.44 3.05e-32 Response to antipsychotic treatment; BRCA cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg24110177 chr3:50126178 RBM5 0.55 16.43 0.54 7.66e-51 Body mass index; BRCA cis rs3784262 0.669 rs2414527 chr15:58256672 A/G cg12031962 chr15:58353849 ALDH1A2 0.36 9.84 0.36 2.22e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs5167 0.504 rs892101 chr19:45455458 G/A cg13119609 chr19:45449297 APOC2 0.47 13.15 0.46 3.79e-35 Blood protein levels; BRCA cis rs11190604 1.000 rs2489046 chr10:102346282 A/C cg07080220 chr10:102295463 HIF1AN 0.54 13.0 0.46 1.89e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg14863265 chr7:2801509 GNA12 -0.45 -9.69 -0.36 8.13e-21 Height; BRCA trans rs11098499 0.863 rs34308924 chr4:120481431 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs7172677 0.737 rs8025412 chr15:75444033 C/T cg14664628 chr15:75095509 CSK -0.41 -8.84 -0.33 9.4e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2797160 1.000 rs1418948 chr6:126007018 C/T cg05901451 chr6:126070800 HEY2 0.39 9.42 0.35 7.86e-20 Endometrial cancer; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg04166393 chr7:2884313 GNA12 0.6 12.16 0.43 9.13e-31 Height; BRCA cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg23248424 chr5:179741104 GFPT2 -0.64 -13.39 -0.47 3.12e-36 Height; BRCA cis rs7766436 0.885 rs6908600 chr6:22582002 C/T cg13666174 chr6:22585274 NA -0.49 -11.52 -0.41 4.92e-28 Coronary artery disease; BRCA cis rs801193 1.000 rs7783924 chr7:66209057 A/C cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs490234 0.783 rs10986848 chr9:128461889 T/C cg14078157 chr9:128172775 NA -0.43 -9.71 -0.36 6.97e-21 Mean arterial pressure; BRCA cis rs3733585 0.664 rs17245436 chr4:9958169 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.4 -0.38 1.65e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11809207 0.523 rs2783628 chr1:26501827 A/C cg00147160 chr1:26503991 CNKSR1 0.28 9.22 0.34 4.24e-19 Height; BRCA cis rs9399135 0.967 rs6915770 chr6:135369214 G/A cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.66e-31 Red blood cell count; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg02353165 chr6:42928485 GNMT 0.73 16.66 0.55 4.9e-52 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs6598955 0.671 rs17162105 chr1:26591255 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.88 0.43 1.49e-29 Personality dimensions; BRCA cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg24675658 chr1:53192096 ZYG11B -0.57 -12.55 -0.44 1.83e-32 Monocyte count; BRCA cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg10560079 chr2:191398806 TMEM194B -0.36 -7.99 -0.3 6.1e-15 Pulse pressure; BRCA cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.49 -0.44 3.62e-32 Bipolar disorder; BRCA cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg19901468 chr14:105411992 AHNAK2 -0.5 -12.12 -0.43 1.36e-30 Rheumatoid arthritis; BRCA cis rs10242455 0.702 rs41385645 chr7:98974038 A/T cg18809830 chr7:99032528 PTCD1 -0.57 -7.94 -0.3 9.01e-15 Blood metabolite levels; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg04944784 chr2:26401820 FAM59B 0.81 11.15 0.4 1.67e-26 Gut microbiome composition (summer); BRCA cis rs7312933 0.510 rs1907705 chr12:42451122 T/A cg17420585 chr12:42539391 GXYLT1 -0.58 -14.53 -0.5 1.62e-41 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg23711669 chr6:146136114 FBXO30 0.69 15.84 0.53 6.42e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs868036 0.881 rs12708496 chr15:68054098 T/C cg08079166 chr15:68083412 MAP2K5 -0.33 -8.72 -0.33 2.35e-17 Restless legs syndrome; BRCA cis rs3857067 0.806 rs1876918 chr4:95099424 G/A cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.33 -0.35 1.77e-19 QT interval; BRCA cis rs9790314 0.586 rs34727114 chr3:161138929 A/C cg03342759 chr3:160939853 NMD3 -0.67 -14.38 -0.49 7.57e-41 Morning vs. evening chronotype; BRCA cis rs4319547 0.915 rs10734924 chr12:123018894 T/G cg23029597 chr12:123009494 RSRC2 -0.64 -12.92 -0.46 4.48e-34 Body mass index; BRCA cis rs57221529 0.766 rs1399381 chr5:589853 G/T cg09021430 chr5:549028 NA -0.68 -14.14 -0.49 1.07e-39 Lung disease severity in cystic fibrosis; BRCA cis rs2204008 0.744 rs11182316 chr12:38499552 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.6 0.57 8.14e-57 Bladder cancer; BRCA cis rs9875589 0.957 rs35485647 chr3:13937937 G/C cg19554555 chr3:13937349 NA 0.41 8.62 0.32 5.43e-17 Ovarian reserve; BRCA cis rs9682041 0.932 rs9841852 chr3:170067049 C/G cg11886554 chr3:170076028 SKIL 0.69 12.97 0.46 2.47e-34 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.59 -0.42 2.52e-28 Lymphocyte counts; BRCA cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg00012203 chr2:219082015 ARPC2 -0.48 -9.27 -0.34 2.92e-19 Colorectal cancer; BRCA cis rs2549003 1.000 rs6894655 chr5:131818649 T/C cg02551604 chr5:131831745 NA -0.39 -14.68 -0.5 2.84e-42 Asthma (sex interaction); BRCA cis rs4363385 0.693 rs582345 chr1:153033406 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.19 -0.31 1.46e-15 Inflammatory skin disease; BRCA trans rs208520 0.754 rs851594 chr6:66876695 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -19.39 -0.61 3.14e-66 Exhaled nitric oxide output; BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg20203395 chr5:56204925 C5orf35 -0.5 -10.61 -0.39 2.55e-24 Initial pursuit acceleration; BRCA cis rs7833790 0.963 rs7836040 chr8:82698328 G/A cg27398817 chr8:82754497 SNX16 -0.41 -7.88 -0.3 1.39e-14 Diastolic blood pressure; BRCA cis rs2730245 0.527 rs2527205 chr7:158706393 G/T cg24397884 chr7:158709396 WDR60 -0.88 -14.96 -0.51 1.26e-43 Height; BRCA cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.28 0.38 4.77e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2075671 0.855 rs11974395 chr7:100282538 G/A cg16850897 chr7:100343110 ZAN -0.58 -12.33 -0.44 1.82e-31 Other erythrocyte phenotypes; BRCA cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg19622623 chr12:86230825 RASSF9 -0.29 -8.19 -0.31 1.45e-15 Major depressive disorder; BRCA cis rs6598955 0.572 rs6598951 chr1:26592714 G/T cg00852783 chr1:26633632 UBXN11 -0.47 -8.29 -0.31 6.69e-16 Obesity-related traits; BRCA cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Bladder cancer; BRCA cis rs2153535 0.526 rs7748404 chr6:8472500 A/T cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 5.07e-18 Motion sickness; BRCA cis rs9807989 0.507 rs6710528 chr2:103016142 A/G cg03938978 chr2:103052716 IL18RAP -0.29 -8.64 -0.32 4.38e-17 Asthma; BRCA cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg24549020 chr5:56110836 MAP3K1 0.59 11.95 0.43 7.8e-30 Initial pursuit acceleration; BRCA cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg04727924 chr7:799746 HEATR2 -0.55 -10.78 -0.39 5.21e-25 Cerebrospinal P-tau181p levels; BRCA cis rs12142240 0.660 rs72885163 chr1:46807117 C/A cg14993813 chr1:46806288 NSUN4 -0.47 -9.07 -0.34 1.48e-18 Menopause (age at onset); BRCA cis rs2032447 0.670 rs71557318 chr6:26118570 T/C cg03264133 chr6:25882463 NA 0.41 8.8 0.33 1.29e-17 Intelligence (multi-trait analysis); BRCA cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg09035930 chr12:129282057 SLC15A4 0.56 16.77 0.55 1.41e-52 Systemic lupus erythematosus; BRCA cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg08999081 chr20:33150536 PIGU 0.44 12.26 0.44 3.36e-31 Glomerular filtration rate (creatinine); BRCA cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg06784218 chr1:46089804 CCDC17 0.52 12.67 0.45 5.52e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg27170947 chr2:26402098 FAM59B -0.66 -11.37 -0.41 2.08e-27 Gut microbiome composition (summer); BRCA cis rs910316 1.000 rs2300601 chr14:75639571 A/G cg23033748 chr14:75592666 NEK9 0.4 9.49 0.35 4.57e-20 Height; BRCA cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg12564285 chr5:131593104 PDLIM4 0.35 9.4 0.35 9.57e-20 Blood metabolite levels; BRCA cis rs7727544 0.514 rs3846728 chr5:131436217 G/A cg14196790 chr5:131705035 SLC22A5 0.36 8.91 0.33 5.44e-18 Blood metabolite levels; BRCA trans rs3857536 0.813 rs9363554 chr6:66930183 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.1 -0.31 2.78e-15 Blood trace element (Cu levels); BRCA cis rs7746199 0.668 rs7749305 chr6:27446566 T/C cg26587870 chr6:27730563 NA -0.71 -9.67 -0.36 1e-20 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg12072164 chr19:44306565 LYPD5 0.38 8.44 0.32 2.08e-16 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs7301826 1.000 rs2001483 chr12:131318645 A/G cg11011512 chr12:131303247 STX2 0.4 10.11 0.37 2.18e-22 Plasma plasminogen activator levels; BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg11814155 chr7:99998594 ZCWPW1 0.48 8.82 0.33 1.05e-17 Platelet count; BRCA cis rs6570726 0.764 rs367065 chr6:145882309 T/G cg13319975 chr6:146136371 FBXO30 -0.38 -8.76 -0.33 1.81e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg21280719 chr6:42927975 GNMT -0.34 -14.18 -0.49 7.25e-40 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7044106 0.500 rs56725168 chr9:123492576 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.8 18.95 0.6 7.21e-64 Hip circumference adjusted for BMI; BRCA cis rs4975709 0.589 rs4975747 chr5:1862836 G/A cg20790798 chr5:1857306 NA -0.36 -8.39 -0.31 3.14e-16 Cardiovascular disease risk factors; BRCA cis rs941873 0.868 rs4980063 chr10:81105844 A/T cg11057378 chr10:81107060 PPIF 0.37 9.22 0.34 4.26e-19 Height; BRCA cis rs7618501 0.521 rs3796386 chr3:49899795 G/A cg14019146 chr3:50243930 SLC38A3 -0.39 -9.64 -0.36 1.22e-20 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg11890956 chr21:40555474 PSMG1 1.06 31.62 0.78 8.54e-133 Cognitive function; BRCA cis rs3820928 0.874 rs10199655 chr2:227892428 T/C cg11843606 chr2:227700838 RHBDD1 -0.35 -7.89 -0.3 1.36e-14 Pulmonary function; BRCA cis rs1348850 0.914 rs6761593 chr2:178451600 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.42 -8.41 -0.32 2.78e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2235642 0.928 rs56289115 chr16:1608934 A/G cg26528668 chr16:1614120 IFT140 0.37 8.37 0.31 3.52e-16 Coronary artery disease; BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13732083 chr21:47605072 C21orf56 0.38 8.06 0.3 3.79e-15 Testicular germ cell tumor; BRCA cis rs9341808 0.718 rs2322631 chr6:80843956 A/C cg08355045 chr6:80787529 NA 0.37 9.43 0.35 7.43e-20 Sitting height ratio; BRCA cis rs72781680 1.000 rs12614452 chr2:24194608 C/T cg08917208 chr2:24149416 ATAD2B 0.93 13.82 0.48 3.34e-38 Lymphocyte counts; BRCA trans rs17685 0.753 rs1637039 chr7:75693009 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 28.23 0.74 1.93e-114 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2882667 0.690 rs288016 chr5:138194988 C/T cg04439458 chr5:138467593 SIL1 0.31 7.96 0.3 7.85e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6964587 0.967 rs10246036 chr7:91558523 G/A cg17063962 chr7:91808500 NA -0.52 -11.93 -0.43 8.84e-30 Breast cancer; BRCA cis rs367943 0.666 rs12332129 chr5:112977983 A/G cg12552261 chr5:112820674 MCC 0.39 8.18 0.31 1.57e-15 Type 2 diabetes; BRCA cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg18357645 chr12:58087776 OS9 -0.31 -7.98 -0.3 6.96e-15 Multiple sclerosis; BRCA cis rs36051895 0.632 rs12349918 chr9:5125250 A/G cg02405213 chr9:5042618 JAK2 -0.47 -8.61 -0.32 5.74e-17 Pediatric autoimmune diseases; BRCA cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg05623727 chr3:50126028 RBM5 0.43 8.35 0.31 4.15e-16 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.808 rs1747522 chr6:25821807 T/A cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs2288073 0.965 rs10185445 chr2:24410976 A/C cg06627628 chr2:24431161 ITSN2 0.62 11.78 0.42 4.13e-29 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg18479299 chr3:125709523 NA -0.56 -8.79 -0.33 1.41e-17 Blood pressure (smoking interaction); BRCA cis rs3087591 0.881 rs2905804 chr17:29519995 T/C cg24425628 chr17:29625626 OMG;NF1 0.41 8.03 0.3 4.65e-15 Hip circumference; BRCA cis rs11112613 0.713 rs73184081 chr12:105951745 C/T cg03607813 chr12:105948248 NA 0.56 10.51 0.38 6.18e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs9287719 0.934 rs6432115 chr2:10748343 G/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs35417517 1 rs35417517 chr7:91772730 CG/C cg17063962 chr7:91808500 NA 0.6 14.47 0.5 2.89e-41 Breast cancer; BRCA cis rs7246657 0.943 rs2291004 chr19:37997952 C/A cg23950597 chr19:37808831 NA -0.71 -12.6 -0.45 1.16e-32 Coronary artery calcification; BRCA cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg00071950 chr4:10020882 SLC2A9 0.54 13.38 0.47 3.69e-36 Bone mineral density; BRCA cis rs9457247 0.534 rs9355610 chr6:167383075 G/A cg23791538 chr6:167370224 RNASET2 0.49 12.41 0.44 7.5e-32 Crohn's disease; BRCA cis rs6028335 0.610 rs67343649 chr20:37557894 A/G cg16355469 chr20:37678765 NA 0.44 8.05 0.3 4.16e-15 Alcohol and nicotine co-dependence; BRCA trans rs2204008 0.605 rs4608149 chr12:38132057 G/C cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00166722 chr3:10149974 C3orf24 0.66 13.38 0.47 3.63e-36 Alzheimer's disease; BRCA cis rs10504229 0.775 rs10504228 chr8:58162053 T/G cg11062466 chr8:58055876 NA 0.5 8.62 0.32 5.13e-17 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.723 rs1026572 chr3:160887654 A/G cg03342759 chr3:160939853 NMD3 -0.54 -11.51 -0.41 5.62e-28 Morning vs. evening chronotype; BRCA cis rs9463078 0.845 rs9349315 chr6:45172289 A/G cg25276700 chr6:44698697 NA -0.36 -8.14 -0.31 2.05e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1005277 0.579 rs2505240 chr10:38442419 G/T cg25427524 chr10:38739819 LOC399744 -0.68 -16.56 -0.55 1.72e-51 Extrinsic epigenetic age acceleration; BRCA trans rs3733585 0.806 rs11723382 chr4:9954660 T/C cg26043149 chr18:55253948 FECH -0.4 -9.07 -0.34 1.42e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg26384229 chr12:38710491 ALG10B 0.8 19.69 0.61 7.86e-68 Heart rate; BRCA cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg03453431 chr7:157225567 NA -0.47 -9.6 -0.35 1.84e-20 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs559928 0.593 rs112275221 chr11:63936994 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 11.58 0.42 2.78e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs2629540 0.765 rs12221075 chr10:126534855 G/A cg08799069 chr10:126477246 METTL10 -0.35 -8.03 -0.3 4.86e-15 Cocaine dependence; BRCA cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.49 -0.32 1.39e-16 Aortic root size; BRCA cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg22800045 chr5:56110881 MAP3K1 0.65 12.22 0.44 5.19e-31 Initial pursuit acceleration; BRCA cis rs7580658 0.926 rs79789049 chr2:128145472 G/A cg09760422 chr2:128146352 NA -0.35 -7.91 -0.3 1.13e-14 Protein C levels; BRCA cis rs6733011 0.578 rs10169003 chr2:99508866 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.35 7.94 0.3 9.25e-15 Bipolar disorder; BRCA cis rs801193 0.569 rs13242290 chr7:66121885 G/A cg11764359 chr7:65958608 NA -0.74 -16.11 -0.54 3.1e-49 Aortic root size; BRCA cis rs2742417 0.603 rs13059502 chr3:45781380 A/G cg04837898 chr3:45731254 SACM1L -0.38 -7.81 -0.3 2.31e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs651907 0.557 rs11712748 chr3:101383562 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.65 16.49 0.55 3.66e-51 Colorectal cancer; BRCA cis rs7246657 0.943 rs713256 chr19:37865365 C/T cg23950597 chr19:37808831 NA -0.73 -12.68 -0.45 4.81e-33 Coronary artery calcification; BRCA cis rs7666738 0.830 rs28728124 chr4:99001116 G/T cg17366294 chr4:99064904 C4orf37 0.46 10.82 0.39 3.67e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3812049 0.737 rs790155 chr5:127498380 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 10.47 0.38 8.64e-24 Lymphocyte counts;Red cell distribution width; BRCA cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.09 0.4 2.92e-26 Bipolar disorder; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg18765753 chr7:1198926 ZFAND2A -0.49 -11.2 -0.41 1.04e-26 Longevity;Endometriosis; BRCA cis rs2731664 0.792 rs335466 chr5:176889530 C/A cg23176889 chr5:176863531 GRK6 -0.62 -17.03 -0.56 6.91e-54 Intelligence (multi-trait analysis); BRCA cis rs2991971 0.967 rs11211130 chr1:45986852 G/C cg15605315 chr1:45957053 TESK2 0.5 10.3 0.38 4.2e-23 High light scatter reticulocyte count; BRCA trans rs12310956 0.510 rs6488178 chr12:33885251 C/G cg26384229 chr12:38710491 ALG10B 0.4 9.27 0.34 2.72e-19 Morning vs. evening chronotype; BRCA cis rs6942407 0.546 rs10257953 chr7:86799726 C/T cg02420886 chr7:86849541 C7orf23 0.54 8.03 0.3 4.54e-15 Food allergy; BRCA cis rs77741769 0.571 rs11065283 chr12:121266453 A/G cg02419362 chr12:121203948 SPPL3 0.34 7.82 0.3 2.17e-14 Mean corpuscular volume; BRCA cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg13319975 chr6:146136371 FBXO30 0.42 9.83 0.36 2.44e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs651907 0.557 rs34624546 chr3:101374226 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.63 0.53 7.23e-47 Colorectal cancer; BRCA cis rs34779708 0.733 rs4298846 chr10:35547380 A/G cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10779751 0.770 rs11121695 chr1:11229515 G/A cg08854313 chr1:11322531 MTOR -0.71 -14.09 -0.49 1.84e-39 Body mass index; BRCA cis rs1707322 1.000 rs785504 chr1:46595696 C/T cg03146154 chr1:46216737 IPP -0.42 -9.0 -0.34 2.52e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 1.000 rs1371553 chr2:26262948 G/A cg26314531 chr2:26401878 FAM59B -0.66 -11.21 -0.41 9.67e-27 Gut microbiome composition (summer); BRCA cis rs2762353 0.935 rs11754288 chr6:25776949 G/A cg12310025 chr6:25882481 NA 0.51 12.09 0.43 1.96e-30 Blood metabolite levels; BRCA cis rs7394190 0.748 rs11000777 chr10:75545063 G/C cg07699608 chr10:75541558 CHCHD1 0.66 10.0 0.37 5.62e-22 Incident atrial fibrillation; BRCA cis rs6701037 0.625 rs67332874 chr1:175128537 G/A cg14847009 chr1:175162515 KIAA0040 -0.25 -9.45 -0.35 6.06e-20 Alcohol dependence; BRCA cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg05340658 chr4:99064831 C4orf37 0.63 15.11 0.51 2.45e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs72772090 0.539 rs17481759 chr5:96114695 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.22 -0.44 5.27e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs35110281 0.744 rs230645 chr21:44918607 A/G cg04455712 chr21:45112962 RRP1B -0.42 -11.18 -0.4 1.27e-26 Mean corpuscular volume; BRCA cis rs41005 0.967 rs41002 chr2:8113921 C/T cg03155496 chr2:8117019 LOC339788 0.63 18.27 0.59 2.68e-60 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs6446731 0.517 rs2071671 chr4:3269787 C/G cg08886695 chr4:3369023 RGS12 0.37 9.84 0.36 2.31e-21 Mean platelet volume; BRCA cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg22800045 chr5:56110881 MAP3K1 0.42 8.36 0.31 4.07e-16 Coronary artery disease; BRCA cis rs17818399 0.815 rs17819022 chr2:46850571 G/A cg02822958 chr2:46747628 ATP6V1E2 0.46 8.08 0.3 3.34e-15 Height; BRCA cis rs644799 1.000 rs617999 chr11:95589935 A/G cg03916912 chr11:95522834 CEP57;FAM76B 0.9 23.24 0.68 4.9e-87 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA trans rs9325144 0.647 rs11169222 chr12:39105210 C/T cg23762105 chr12:34175262 ALG10 0.35 7.86 0.3 1.66e-14 Morning vs. evening chronotype; BRCA cis rs2066819 1.000 rs41423244 chr12:56693520 A/C cg26734620 chr12:56694298 CS -0.88 -10.19 -0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 4.11e-25 Bipolar disorder; BRCA cis rs1707322 1.000 rs4660336 chr1:46487976 T/C cg03146154 chr1:46216737 IPP -0.45 -10.13 -0.37 1.84e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10193935 0.901 rs2374405 chr2:42479874 A/C cg27598129 chr2:42591480 NA -0.94 -14.7 -0.5 2.32e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs8031584 0.679 rs34017474 chr15:31230611 T/C cg08109568 chr15:31115862 NA -0.35 -8.54 -0.32 1.01e-16 Huntington's disease progression; BRCA cis rs11971779 0.648 rs6467849 chr7:139080512 C/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs6964587 1.000 rs415 chr7:91580490 A/G cg17063962 chr7:91808500 NA -0.52 -12.28 -0.44 2.88e-31 Breast cancer; BRCA cis rs7605378 1.000 rs769957 chr2:200695524 A/C cg23649088 chr2:200775458 C2orf69 0.5 9.94 0.37 9.36e-22 Osteoporosis; BRCA cis rs12762955 0.561 rs4880744 chr10:1012026 A/G cg20503657 chr10:835505 NA -0.53 -9.83 -0.36 2.59e-21 Response to angiotensin II receptor blocker therapy; BRCA cis rs11098499 0.754 rs878372 chr4:120238780 A/C cg09307838 chr4:120376055 NA 0.64 13.9 0.48 1.39e-38 Corneal astigmatism; BRCA cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs11764590 0.694 rs6972969 chr7:2099331 A/G cg23422044 chr7:1970798 MAD1L1 -0.45 -9.53 -0.35 3.34e-20 Neuroticism; BRCA trans rs61931739 0.534 rs7138522 chr12:34039762 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.85e-20 Morning vs. evening chronotype; BRCA cis rs7561273 0.586 rs116650625 chr2:24353212 C/G cg04809136 chr2:24300158 SF3B14 -0.4 -8.94 -0.33 4.13e-18 Quantitative traits; BRCA cis rs6484504 0.532 rs12788257 chr11:31255045 T/C cg26647111 chr11:31128758 NA -0.45 -9.7 -0.36 7.87e-21 Red blood cell count; BRCA cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg19077165 chr18:44547161 KATNAL2 -0.55 -11.72 -0.42 7.41e-29 Personality dimensions; BRCA cis rs2204008 0.777 rs114096617 chr12:38342557 A/C cg13010199 chr12:38710504 ALG10B 0.5 10.31 0.38 3.67e-23 Bladder cancer; BRCA cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg06159980 chr1:16340746 HSPB7 -0.37 -7.88 -0.3 1.39e-14 Dilated cardiomyopathy; BRCA cis rs4819052 0.851 rs4819039 chr21:46659458 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10267417 0.535 rs10272487 chr7:19862415 A/T cg07541023 chr7:19748670 TWISTNB 0.53 9.43 0.35 7.52e-20 Night sleep phenotypes; BRCA trans rs877282 0.891 rs12767043 chr10:797943 C/T cg22713356 chr15:30763199 NA 1.41 28.95 0.75 2.23e-118 Uric acid levels; BRCA cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg09877947 chr5:131593287 PDLIM4 0.37 7.96 0.3 8e-15 Breast cancer; BRCA cis rs9868809 0.505 rs9877685 chr3:48748588 C/T cg01304814 chr3:48885189 PRKAR2A 0.56 7.86 0.3 1.69e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs8180040 0.627 rs58956475 chr3:47224615 G/C cg16586182 chr3:47516702 SCAP 0.56 12.53 0.44 2.25e-32 Colorectal cancer; BRCA cis rs7249142 0.549 rs12609573 chr19:19297567 C/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.44 10.68 0.39 1.29e-24 IgG glycosylation; BRCA cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg00409905 chr10:38381863 ZNF37A -0.48 -10.22 -0.37 8.3300000000000006e-23 Extrinsic epigenetic age acceleration; BRCA cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg06582575 chr6:163149167 PACRG;PARK2 -0.49 -9.33 -0.35 1.76e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs354225 0.546 rs10170646 chr2:54799606 T/C cg26097391 chr2:54893211 SPTBN1 0.29 8.73 0.33 2.21e-17 Schizophrenia; BRCA cis rs910316 1.000 rs175425 chr14:75626131 T/C cg23033748 chr14:75592666 NEK9 -0.43 -10.46 -0.38 9.28e-24 Height; BRCA cis rs9341808 0.667 rs1408292 chr6:80883906 G/T cg08355045 chr6:80787529 NA 0.33 8.12 0.31 2.47e-15 Sitting height ratio; BRCA cis rs9976767 0.608 rs3746923 chr21:43826344 C/T cg23042151 chr21:43824109 UBASH3A -0.27 -8.38 -0.31 3.28e-16 Type 1 diabetes; BRCA cis rs826838 0.967 rs1719852 chr12:39128531 A/G cg26384229 chr12:38710491 ALG10B -0.62 -15.95 -0.53 1.75e-48 Heart rate; BRCA cis rs9814567 1.000 rs1863913 chr3:134200205 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.12 -0.6 9.11e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6484504 0.576 rs208103 chr11:31167400 A/G cg14844989 chr11:31128820 NA -0.45 -9.53 -0.35 3.16e-20 Red blood cell count; BRCA cis rs1005277 0.579 rs2474587 chr10:38420666 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -16.7 -0.55 3.21e-52 Extrinsic epigenetic age acceleration; BRCA cis rs7588746 0.868 rs12104649 chr2:201128832 C/T cg23649088 chr2:200775458 C2orf69 -0.45 -8.05 -0.3 4.07e-15 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs7618915 0.547 rs6762813 chr3:52726695 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.98 0.4 8.23e-26 Bipolar disorder; BRCA cis rs2797160 1.000 rs1578794 chr6:126015469 T/C cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.2e-20 Endometrial cancer; BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 7.96 0.3 7.92e-15 Tonsillectomy; BRCA cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg03146154 chr1:46216737 IPP 0.47 10.37 0.38 2.16e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg05623727 chr3:50126028 RBM5 -0.48 -11.64 -0.42 1.63e-28 Body mass index; BRCA cis rs7572733 0.534 rs6434943 chr2:198762192 T/G cg00792783 chr2:198669748 PLCL1 0.48 10.31 0.38 3.72e-23 Dermatomyositis; BRCA cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg10802521 chr3:52805072 NEK4 -0.32 -7.95 -0.3 8.7e-15 Bipolar disorder; BRCA cis rs1401999 1.000 rs939337 chr3:183701147 G/C cg01324343 chr3:183735012 ABCC5 0.85 21.67 0.65 1.68e-78 Anterior chamber depth; BRCA cis rs6066835 1.000 rs6063311 chr20:47325315 C/T cg18078177 chr20:47281410 PREX1 0.72 7.83 0.3 2.06e-14 Multiple myeloma; BRCA cis rs6570726 0.935 rs397418 chr6:145842362 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.89 0.51 2.9e-43 Lobe attachment (rater-scored or self-reported); BRCA trans rs6951245 1.000 rs76129108 chr7:1089159 G/A cg13565492 chr6:43139072 SRF -0.79 -10.84 -0.39 2.99e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.865 rs11098513 chr4:120316075 A/G cg25214090 chr10:38739885 LOC399744 0.52 12.03 0.43 3.48e-30 Corneal astigmatism; BRCA cis rs11229555 1.000 rs11229543 chr11:58370698 G/A cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6089829 0.925 rs2277767 chr20:61666937 G/A cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg08392591 chr16:89556376 ANKRD11 0.41 9.78 0.36 3.87e-21 Multiple myeloma (IgH translocation); BRCA cis rs6831352 0.734 rs1453872 chr4:100022482 G/A cg12011299 chr4:100065546 ADH4 0.42 10.46 0.38 9.74e-24 Alcohol dependence; BRCA trans rs61931739 0.534 rs10844828 chr12:34303109 C/T cg26384229 chr12:38710491 ALG10B 0.47 10.66 0.39 1.5e-24 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs1937131 chr6:25744831 A/T cg16482183 chr6:26056742 HIST1H1C -0.44 -8.48 -0.32 1.58e-16 Iron status biomarkers; BRCA cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.29 0.41 4.47e-27 Bipolar disorder; BRCA cis rs7666738 0.830 rs6817645 chr4:99016054 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9399137 0.507 rs11154791 chr6:135379148 A/G cg22676075 chr6:135203613 NA 0.44 8.68 0.32 3.23e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs12950390 0.853 rs12450733 chr17:45855404 A/G cg03474202 chr17:45855739 NA -0.47 -12.62 -0.45 9.36e-33 IgG glycosylation; BRCA cis rs9880211 0.948 rs13321721 chr3:136209550 A/G cg21827317 chr3:136751795 NA -0.46 -8.31 -0.31 5.54e-16 Body mass index;Height; BRCA cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.99 15.2 0.52 8.85e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7246760 0.867 rs55800282 chr19:9833530 A/G cg02900749 chr2:68251473 NA -0.48 -7.93 -0.3 1e-14 Pursuit maintenance gain; BRCA cis rs2991971 0.901 rs11211122 chr1:45954650 C/T cg24296786 chr1:45957014 TESK2 0.63 15.01 0.51 7.95e-44 High light scatter reticulocyte count; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg05457628 chr5:178986728 RUFY1 0.57 14.34 0.49 1.26e-40 Lung cancer; BRCA cis rs7523050 0.643 rs67091034 chr1:109402567 C/G cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs6088580 0.609 rs945674 chr20:32964247 G/C cg08999081 chr20:33150536 PIGU -0.47 -12.94 -0.46 3.37e-34 Glomerular filtration rate (creatinine); BRCA cis rs11792861 0.816 rs11788336 chr9:111688387 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.05 0.3 4.02e-15 Menarche (age at onset); BRCA cis rs1163251 0.902 rs627707 chr1:120217133 C/G cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs10208940 0.777 rs6726966 chr2:68855856 A/G cg12452813 chr2:68675892 NA 0.49 8.76 0.33 1.79e-17 Urate levels in lean individuals; BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg14863265 chr7:2801509 GNA12 -0.47 -10.07 -0.37 2.97e-22 Height; BRCA cis rs312274 0.550 rs17621741 chr12:41300290 G/T cg17827154 chr12:41323612 CNTN1 0.41 10.44 0.38 1.2e-23 Metabolite levels (X-11787); BRCA cis rs1580019 0.844 rs1037322 chr7:32501857 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.88 19.6 0.61 2.39e-67 Cognitive ability; BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.09 -0.4 2.84e-26 Lymphocyte counts; BRCA cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA trans rs61931739 0.500 rs11052994 chr12:34065843 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.37 0.35 1.19e-19 Morning vs. evening chronotype; BRCA cis rs6951245 0.554 rs79367977 chr7:1152657 G/A cg22907277 chr7:1156413 C7orf50 0.61 12.02 0.43 3.94e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs919433 0.783 rs805497 chr2:198222548 A/T cg00792783 chr2:198669748 PLCL1 0.37 8.34 0.31 4.62e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg08236123 chr12:132219811 SFRS8 -0.49 -11.1 -0.4 2.78e-26 Migraine; BRCA cis rs7666738 0.830 rs957742 chr4:99029409 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs654950 0.783 rs668359 chr1:42003425 A/C cg06885757 chr1:42089581 HIVEP3 -0.25 -8.78 -0.33 1.52e-17 Airway imaging phenotypes; BRCA cis rs10197940 0.510 rs7557092 chr2:152423459 T/A cg19508488 chr2:152266495 RIF1 0.48 8.83 0.33 1.03e-17 Lung cancer; BRCA cis rs9487051 0.702 rs670414 chr6:109529912 A/G cg21918786 chr6:109611834 NA 0.36 9.2 0.34 5.1e-19 Reticulocyte fraction of red cells; BRCA cis rs17401966 0.931 rs3748577 chr1:10357406 C/T cg19773385 chr1:10388646 KIF1B 0.37 8.18 0.31 1.48e-15 Hepatocellular carcinoma; BRCA cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg04586622 chr2:25135609 ADCY3 0.46 11.45 0.41 9.79e-28 Body mass index; BRCA cis rs9291683 0.679 rs2241483 chr4:10099831 A/G cg00071950 chr4:10020882 SLC2A9 -0.51 -12.27 -0.44 3.26e-31 Bone mineral density; BRCA cis rs7666738 0.830 rs4699595 chr4:99012827 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs858239 0.600 rs28483572 chr7:23131785 A/G cg23682824 chr7:23144976 KLHL7 0.45 11.89 0.43 1.36e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs7044106 0.791 rs10985008 chr9:123492960 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.72 16.18 0.54 1.34e-49 Hip circumference adjusted for BMI; BRCA cis rs585510 1 rs585510 chr12:121000133 A/G cg12219531 chr12:120966889 COQ5 0.55 11.56 0.42 3.51e-28 Reticulocyte fraction of red cells; BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg04944784 chr2:26401820 FAM59B -0.85 -13.27 -0.46 1.19e-35 Gut microbiome composition (summer); BRCA cis rs1953600 0.870 rs2789690 chr10:81938204 G/T cg04850286 chr10:81895943 PLAC9 0.31 8.93 0.33 4.44e-18 Sarcoidosis; BRCA cis rs7091068 0.671 rs588912 chr10:95402929 T/C cg20715218 chr10:95462985 C10orf4 -0.46 -8.32 -0.31 5.3e-16 Urinary tract infection frequency; BRCA cis rs929596 0.728 rs6744284 chr2:234625297 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.47 -12.41 -0.44 7.57e-32 Total bilirubin levels in HIV-1 infection; BRCA cis rs2066819 1.000 rs59295315 chr12:56708576 G/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg06640241 chr16:89574553 SPG7 0.78 19.07 0.6 1.69e-64 Multiple myeloma (IgH translocation); BRCA cis rs2836974 0.899 rs6517514 chr21:40527095 G/T cg11644478 chr21:40555479 PSMG1 0.85 19.85 0.62 1.1e-68 Cognitive function; BRCA cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg23895963 chr12:117471115 NA 0.54 9.61 0.36 1.58e-20 Subcortical brain region volumes;Hippocampal volume; BRCA trans rs11764590 0.715 rs9639202 chr7:2087315 G/A cg25206134 chr2:45395956 NA 0.51 8.22 0.31 1.11e-15 Neuroticism; BRCA cis rs28735056 0.592 rs10853392 chr18:77708781 A/G cg05491587 chr18:77659695 KCNG2 0.32 8.1 0.31 2.82e-15 Schizophrenia; BRCA trans rs11098499 0.863 rs2170276 chr4:120485824 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs9649213 0.614 rs3801258 chr7:97988428 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.78 -0.53 1.24e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.593 rs7458551 chr7:97952167 G/C cg24562669 chr7:97807699 LMTK2 0.43 11.7 0.42 8.48e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.747 rs4845508 chr1:152968421 G/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.08 -0.34 1.35e-18 Inflammatory skin disease; BRCA trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg13010199 chr12:38710504 ALG10B 0.42 9.03 0.34 2.09e-18 Morning vs. evening chronotype; BRCA cis rs7615952 0.641 rs12495947 chr3:125771698 C/T cg06494592 chr3:125709126 NA -0.53 -8.18 -0.31 1.53e-15 Blood pressure (smoking interaction); BRCA trans rs7618501 1.000 rs7648987 chr3:49868455 A/G cg21582582 chr3:182698605 DCUN1D1 0.36 9.52 0.35 3.44e-20 Intelligence (multi-trait analysis); BRCA cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg01017244 chr2:74357527 NA 0.41 8.95 0.33 3.92e-18 Gestational age at birth (maternal effect); BRCA cis rs992157 0.866 rs2292554 chr2:219146868 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.51 -11.09 -0.4 3e-26 Colorectal cancer; BRCA cis rs7772486 0.623 rs735535 chr6:146036829 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -16.79 -0.55 1.14e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.597 rs9386136 chr6:146158300 A/T cg05347473 chr6:146136440 FBXO30 0.61 12.12 0.43 1.47e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg20701182 chr2:24300061 SF3B14 0.71 13.26 0.46 1.27e-35 Lymphocyte counts; BRCA cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 11.58 0.42 2.74e-28 Colonoscopy-negative controls vs population controls; BRCA trans rs208520 0.909 rs9453672 chr6:66991431 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.71 12.28 0.44 2.94e-31 Exhaled nitric oxide output; BRCA cis rs9443645 0.901 rs9448588 chr6:79590061 T/G cg18132916 chr6:79620363 NA -0.44 -10.07 -0.37 3.15e-22 Intelligence (multi-trait analysis); BRCA cis rs7258465 1.000 rs7258465 chr19:18533642 A/G cg01065977 chr19:18549689 ISYNA1 -0.29 -8.56 -0.32 8.13e-17 Breast cancer; BRCA cis rs1953600 0.754 rs2573348 chr10:81925785 C/T cg04850286 chr10:81895943 PLAC9 -0.32 -8.98 -0.33 2.91e-18 Sarcoidosis; BRCA cis rs7917772 0.503 rs7904955 chr10:104367092 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.18 0.58 7.51e-60 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7727544 0.660 rs272886 chr5:131665840 T/C cg07395648 chr5:131743802 NA -0.36 -9.15 -0.34 7.58e-19 Blood metabolite levels; BRCA cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg06697600 chr4:7070879 GRPEL1 -0.55 -11.44 -0.41 1.08e-27 Monocyte percentage of white cells; BRCA cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.94 13.91 0.48 1.23e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7560272 0.501 rs2006997 chr2:73947846 G/A cg20560298 chr2:73613845 ALMS1 0.33 8.23 0.31 1.05e-15 Schizophrenia; BRCA cis rs698833 0.780 rs9309115 chr2:44510146 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.31 0.35 2.02e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg16325326 chr1:53192061 ZYG11B -0.65 -16.23 -0.54 7.41e-50 Monocyte count; BRCA cis rs10746514 1.000 rs12129814 chr1:232251730 C/A cg09506761 chr1:232265262 NA 0.4 8.07 0.3 3.5e-15 Response to statin therapy; BRCA cis rs2404602 0.660 rs11852777 chr15:76929792 A/G cg23625390 chr15:77176239 SCAPER -0.54 -13.4 -0.47 2.99e-36 Blood metabolite levels; BRCA cis rs7607369 0.680 rs533760 chr2:219381405 T/C cg02176678 chr2:219576539 TTLL4 0.46 11.94 0.43 8.44e-30 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs1401999 1.000 rs2313217 chr3:183635997 A/G cg01324343 chr3:183735012 ABCC5 0.84 21.16 0.64 1.03e-75 Anterior chamber depth; BRCA cis rs7772486 0.875 rs2073287 chr6:146350264 T/C cg23711669 chr6:146136114 FBXO30 0.65 15.32 0.52 2.47e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg18230493 chr5:56204884 C5orf35 0.61 12.94 0.46 3.57e-34 Initial pursuit acceleration; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.35 -0.44 1.39e-31 Lymphocyte counts; BRCA cis rs7267979 0.932 rs2260997 chr20:25256266 A/C cg08601574 chr20:25228251 PYGB -0.35 -8.31 -0.31 5.92e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10227331 1.000 rs11979293 chr7:157293586 C/T cg04156418 chr7:157293606 NA 0.38 11.11 0.4 2.51e-26 Inattentive symptoms; BRCA cis rs9549328 0.800 rs1317507 chr13:113631780 G/T cg17524180 chr13:113633600 MCF2L -0.33 -8.41 -0.32 2.75e-16 Systolic blood pressure; BRCA cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg20607798 chr8:58055168 NA 0.45 8.03 0.3 4.7e-15 Developmental language disorder (linguistic errors); BRCA cis rs9467773 0.595 rs9366657 chr6:26434914 C/G cg09904177 chr6:26538194 HMGN4 0.37 9.75 0.36 5.1e-21 Intelligence (multi-trait analysis); BRCA cis rs4713118 0.869 rs9461405 chr6:27719375 G/T cg26587870 chr6:27730563 NA -0.4 -8.49 -0.32 1.43e-16 Parkinson's disease; BRCA cis rs7824557 0.628 rs7841394 chr8:11185671 G/T cg21775007 chr8:11205619 TDH 0.73 16.87 0.56 4.13e-53 Retinal vascular caliber; BRCA cis rs2637030 0.559 rs187659 chr5:52916018 G/A cg06476337 chr5:52856530 NDUFS4 0.38 8.77 0.33 1.62e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs6582630 0.593 rs7134006 chr12:38596245 A/C cg13010199 chr12:38710504 ALG10B 0.45 9.47 0.35 5.17e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs10788264 0.513 rs10749455 chr10:124035030 A/G cg09507567 chr10:124027408 NA 0.38 7.98 0.3 7e-15 Total body bone mineral density; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg07343612 chr16:622815 PIGQ -0.68 -22.12 -0.66 6.32e-81 Height; BRCA cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.84 0.42 2.3e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg09184832 chr6:79620586 NA -0.51 -11.2 -0.4 1.07e-26 Intelligence (multi-trait analysis); BRCA cis rs2115630 1.000 rs4633690 chr15:85361960 C/T cg12863693 chr15:85201151 NMB -0.37 -8.98 -0.33 3.07e-18 P wave terminal force; BRCA cis rs11690935 0.885 rs6750058 chr2:172786909 G/T cg13550731 chr2:172543902 DYNC1I2 -0.8 -23.44 -0.68 3.87e-88 Schizophrenia; BRCA cis rs7131987 0.834 rs1989478 chr12:29442229 C/T cg09582351 chr12:29534625 ERGIC2 -0.48 -11.56 -0.42 3.21e-28 QT interval; BRCA cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg25036284 chr2:26402008 FAM59B -0.46 -8.11 -0.31 2.67e-15 Gut microbiome composition (summer); BRCA cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg10523679 chr1:76189770 ACADM 0.68 12.42 0.44 7.22e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9300255 0.679 rs12829456 chr12:123725395 C/T cg00376283 chr12:123451042 ABCB9 -0.55 -10.63 -0.39 2.12e-24 Neutrophil percentage of white cells; BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg13047869 chr3:10149882 C3orf24 0.6 12.73 0.45 3.12e-33 Alzheimer's disease; BRCA cis rs2882667 0.522 rs7731574 chr5:138454192 A/G cg04439458 chr5:138467593 SIL1 0.3 8.0 0.3 5.85e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7809950 0.953 rs3094383 chr7:107143164 G/A cg23024343 chr7:107201750 COG5 -0.4 -9.12 -0.34 9.56e-19 Coronary artery disease; BRCA cis rs2346177 0.638 rs34186951 chr2:46657659 A/G cg02822958 chr2:46747628 ATP6V1E2 0.46 9.5 0.35 4.27e-20 HDL cholesterol; BRCA cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg01579765 chr21:45077557 HSF2BP -0.39 -10.43 -0.38 1.31e-23 Mean corpuscular volume; BRCA cis rs1997103 1.000 rs4947503 chr7:55409427 G/T cg17469321 chr7:55412551 NA 0.51 9.62 0.36 1.53e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs939658 0.805 rs35230534 chr15:79441093 T/C cg17916960 chr15:79447300 NA -0.43 -10.98 -0.4 8.11e-26 Refractive error; BRCA cis rs17270561 0.609 rs9393655 chr6:25711338 A/G cg16482183 chr6:26056742 HIST1H1C 0.43 8.41 0.32 2.68e-16 Iron status biomarkers; BRCA cis rs6570726 0.764 rs366673 chr6:145814628 T/A cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.15e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg10802521 chr3:52805072 NEK4 -0.32 -8.32 -0.31 5.32e-16 Bipolar disorder; BRCA cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -18.17 -0.58 8.2e-60 Initial pursuit acceleration; BRCA cis rs7520050 0.872 rs1707308 chr1:46604315 G/A cg24296786 chr1:45957014 TESK2 0.38 8.4 0.32 2.78e-16 Red blood cell count;Reticulocyte count; BRCA cis rs55883249 1.000 rs62119422 chr2:9726599 A/G cg23886495 chr2:9695866 ADAM17 0.56 7.97 0.3 7.16e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.34 11.35 0.41 2.54e-27 Systemic lupus erythematosus; BRCA cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg21918786 chr6:109611834 NA -0.46 -12.86 -0.45 7.82e-34 Reticulocyte fraction of red cells; BRCA trans rs7980799 0.654 rs1482987 chr12:33614283 G/C cg26384229 chr12:38710491 ALG10B -0.49 -10.67 -0.39 1.46e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs1878931 0.668 rs11643983 chr16:3438865 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.98 26.54 0.72 3.54e-105 Body mass index (adult); BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg21747090 chr2:27597821 SNX17 -0.44 -9.64 -0.36 1.25e-20 Total body bone mineral density; BRCA cis rs7085104 0.700 rs7096183 chr10:104609466 T/C cg04362960 chr10:104952993 NT5C2 0.4 9.57 0.35 2.3e-20 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs9815354 0.812 rs35263917 chr3:41952852 T/C cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7927592 0.513 rs7950129 chr11:68202903 A/G cg01657329 chr11:68192670 LRP5 -0.4 -9.96 -0.37 8.02e-22 Total body bone mineral density; BRCA cis rs965469 0.843 rs6037597 chr20:3408374 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.17 -0.37 1.25e-22 IFN-related cytopenia; BRCA cis rs6459788 0.934 rs10251462 chr7:157258183 C/G cg03453431 chr7:157225567 NA -0.39 -8.1 -0.31 2.84e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg23018236 chr17:30244563 NA -0.73 -12.0 -0.43 4.79e-30 Hip circumference adjusted for BMI; BRCA cis rs9649213 0.593 rs6961438 chr7:98005849 T/C cg21770322 chr7:97807741 LMTK2 0.43 11.14 0.4 1.9e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs798554 0.679 rs1639036 chr7:2885089 G/A cg19346786 chr7:2764209 NA -0.3 -9.46 -0.35 5.94e-20 Height; BRCA cis rs4653767 1.000 rs10495249 chr1:226919119 A/G cg05049329 chr1:226924846 ITPKB 0.33 9.31 0.35 2.01e-19 Parkinson's disease; BRCA cis rs9487051 0.872 rs6924815 chr6:109612344 A/G cg21918786 chr6:109611834 NA -0.49 -14.16 -0.49 8.35e-40 Reticulocyte fraction of red cells; BRCA cis rs2180341 0.960 rs9398842 chr6:127674662 T/C cg27446573 chr6:127587934 RNF146 0.86 20.0 0.62 1.76e-69 Breast cancer; BRCA trans rs1005277 0.579 rs2474586 chr10:38418882 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -14.16 -0.49 8.76e-40 Extrinsic epigenetic age acceleration; BRCA cis rs4880487 0.924 rs10903404 chr10:1248591 C/A cg03183215 chr10:1252341 ADARB2 -0.39 -8.51 -0.32 1.26e-16 Migraine; BRCA cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.42 -9.35 -0.35 1.4e-19 Aortic root size; BRCA cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg26597838 chr10:835615 NA -0.9 -15.35 -0.52 1.62e-45 Eosinophil percentage of granulocytes; BRCA cis rs4478137 0.931 rs56233753 chr4:164249023 A/G cg06758707 chr4:164254230 NPY1R 0.53 11.61 0.42 2.09e-28 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs870825 0.616 rs6552804 chr4:185637699 A/G cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs769267 0.930 rs2301786 chr19:19413947 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.47 9.93 0.37 1.03e-21 Tonsillectomy; BRCA cis rs9309473 0.519 rs2421545 chr2:73639476 T/C cg20560298 chr2:73613845 ALMS1 0.41 11.21 0.41 9.76e-27 Metabolite levels; BRCA cis rs6893300 0.560 rs1019443 chr5:179207547 A/G cg14593053 chr5:179126677 CANX -0.47 -12.41 -0.44 7.5e-32 Resting heart rate; BRCA trans rs2727020 0.619 rs11040300 chr11:49269984 C/A cg15704280 chr7:45808275 SEPT13 0.7 13.95 0.48 8.34e-39 Coronary artery disease; BRCA cis rs2239547 0.563 rs6445547 chr3:52908577 T/C cg11645453 chr3:52864694 ITIH4 0.47 10.97 0.4 8.95e-26 Schizophrenia; BRCA cis rs11098499 0.691 rs2136911 chr4:120265859 G/A cg09307838 chr4:120376055 NA 0.59 12.89 0.45 5.65e-34 Corneal astigmatism; BRCA cis rs1008375 1.000 rs10939738 chr4:17604295 G/C cg15017067 chr4:17643749 FAM184B 0.28 8.48 0.32 1.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9649213 0.537 rs6465663 chr7:97918883 C/G cg24562669 chr7:97807699 LMTK2 0.47 12.62 0.45 8.98e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs35306767 0.903 rs12761424 chr10:967295 C/T cg20503657 chr10:835505 NA 0.87 15.96 0.53 1.75e-48 Eosinophil percentage of granulocytes; BRCA cis rs7937840 0.581 rs4963461 chr11:61884044 G/A cg01969543 chr11:61895209 INCENP -0.38 -8.28 -0.31 7.49e-16 Breast cancer; BRCA cis rs965469 0.545 rs6051846 chr20:3403824 A/G cg25506879 chr20:3388711 C20orf194 0.46 9.82 0.36 2.62e-21 IFN-related cytopenia; BRCA cis rs35110281 0.774 rs1378080 chr21:45011315 T/A cg21573476 chr21:45109991 RRP1B -0.34 -8.64 -0.32 4.57e-17 Mean corpuscular volume; BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg04267008 chr7:1944627 MAD1L1 -0.65 -13.6 -0.47 3.45e-37 Bipolar disorder and schizophrenia; BRCA cis rs56116382 0.604 rs9858428 chr3:49877585 G/T cg00383909 chr3:49044727 WDR6 0.7 10.52 0.38 5.52e-24 Intelligence (multi-trait analysis);High light scatter reticulocyte count; BRCA cis rs2795502 1.000 rs2744090 chr10:43339614 G/C cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg11833968 chr6:79620685 NA -0.44 -9.97 -0.37 7.64e-22 Intelligence (multi-trait analysis); BRCA cis rs7737355 0.947 rs10073137 chr5:131091089 A/G cg06307176 chr5:131281290 NA 0.53 10.18 0.37 1.16e-22 Life satisfaction; BRCA cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.68e-16 Putamen volume; BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg23285459 chr7:2802560 GNA12 0.35 9.11 0.34 1.05e-18 Height; BRCA cis rs6495367 1.000 rs745030 chr15:79381705 G/A cg17916960 chr15:79447300 NA 0.34 8.35 0.31 4.33e-16 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg05084668 chr3:125655381 ALG1L -0.47 -8.08 -0.3 3.23e-15 Blood pressure (smoking interaction); BRCA cis rs7301826 1.000 rs1609985 chr12:131320170 A/G cg11011512 chr12:131303247 STX2 0.41 10.37 0.38 2.2e-23 Plasma plasminogen activator levels; BRCA trans rs6479891 1.000 rs72837070 chr10:65274679 T/C cg14819942 chr15:35414228 NA 0.34 8.37 0.31 3.74e-16 Arthritis (juvenile idiopathic); BRCA cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg23583168 chr7:148888333 NA -0.89 -21.58 -0.65 5.66e-78 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg08847533 chr14:75593920 NEK9 -0.8 -19.35 -0.61 4.97e-66 Height; BRCA cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg26384229 chr12:38710491 ALG10B 0.53 13.39 0.47 3.17e-36 Morning vs. evening chronotype; BRCA cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg00106254 chr7:1943704 MAD1L1 -0.31 -8.24 -0.31 1.01e-15 Bipolar disorder and schizophrenia; BRCA cis rs68170813 0.559 rs75932578 chr7:106844694 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.33 -0.31 4.95e-16 Coronary artery disease; BRCA cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.74 17.41 0.57 7.55e-56 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg05890377 chr2:74357713 NA 0.48 11.65 0.42 1.4e-28 Gestational age at birth (maternal effect); BRCA trans rs1005277 0.540 rs11011351 chr10:38030525 A/G cg17830980 chr10:43048298 ZNF37B -0.41 -9.62 -0.36 1.48e-20 Extrinsic epigenetic age acceleration; BRCA cis rs7927771 0.832 rs10838704 chr11:47424717 T/C cg20307385 chr11:47447363 PSMC3 -0.43 -8.75 -0.33 1.87e-17 Subjective well-being; BRCA cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs758324 0.853 rs4705902 chr5:131150267 C/G cg06307176 chr5:131281290 NA 0.53 10.28 0.38 4.8e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs2549003 0.966 rs10065633 chr5:131816716 T/C cg02551604 chr5:131831745 NA -0.39 -14.68 -0.5 2.84e-42 Asthma (sex interaction); BRCA cis rs6952808 0.689 rs1107591 chr7:2041638 G/A cg04267008 chr7:1944627 MAD1L1 -0.56 -12.6 -0.45 1.18e-32 Bipolar disorder and schizophrenia; BRCA cis rs6088813 0.845 rs2378349 chr20:33925843 C/A cg14752227 chr20:34000481 UQCC 0.4 8.54 0.32 9.96e-17 Height; BRCA cis rs12618769 0.520 rs72821904 chr2:99084882 G/A cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg27478167 chr7:817139 HEATR2 -0.45 -9.66 -0.36 1.08e-20 Cerebrospinal P-tau181p levels; BRCA cis rs7809950 0.954 rs2712193 chr7:107125885 A/C cg23024343 chr7:107201750 COG5 -0.41 -9.54 -0.35 2.86e-20 Coronary artery disease; BRCA cis rs12477438 0.520 rs6712704 chr2:99719687 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.69 0.39 1.17e-24 Chronic sinus infection; BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg03709012 chr19:19516395 GATAD2A -0.8 -18.43 -0.59 3.95e-61 Tonsillectomy; BRCA cis rs9486719 1.000 rs11153023 chr6:96968525 C/T cg06623918 chr6:96969491 KIAA0776 -0.72 -12.56 -0.44 1.71e-32 Migraine;Coronary artery disease; BRCA cis rs12477438 0.520 rs6542864 chr2:99725223 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.99 0.67 1.05e-85 Chronic sinus infection; BRCA cis rs10751667 0.643 rs6597970 chr11:928669 C/A ch.11.42038R chr11:967971 AP2A2 0.51 15.98 0.53 1.27e-48 Alzheimer's disease (late onset); BRCA cis rs4363385 0.818 rs653332 chr1:153010481 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.18 -0.34 5.72e-19 Inflammatory skin disease; BRCA cis rs1046896 1.000 rs1046896 chr17:80685533 A/G cg05255149 chr17:80675120 FN3KRP -0.39 -7.83 -0.3 2.05e-14 Glycated hemoglobin levels; BRCA cis rs4595586 0.679 rs4768471 chr12:39325960 G/A cg26384229 chr12:38710491 ALG10B 0.38 8.69 0.33 2.97e-17 Morning vs. evening chronotype; BRCA cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg26031613 chr14:104095156 KLC1 -0.43 -8.47 -0.32 1.74e-16 Schizophrenia; BRCA cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg04450456 chr4:17643702 FAM184B 0.32 9.39 0.35 1.08e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4800452 0.826 rs8094261 chr18:20746728 C/G cg26136497 chr18:20735537 CABLES1 -0.39 -9.39 -0.35 1.05e-19 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA trans rs1005277 0.522 rs7090858 chr10:38003670 A/C cg17830980 chr10:43048298 ZNF37B 0.43 10.19 0.37 1.04e-22 Extrinsic epigenetic age acceleration; BRCA trans rs61931739 0.500 rs10844848 chr12:34409705 A/C cg26384229 chr12:38710491 ALG10B 0.75 16.69 0.55 3.44e-52 Morning vs. evening chronotype; BRCA cis rs870825 1.000 rs870825 chr4:185588045 A/G cg20176042 chr4:185552304 CASP3 -0.55 -8.03 -0.3 4.67e-15 Blood protein levels; BRCA cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg14926445 chr8:58193284 C8orf71 -0.42 -8.19 -0.31 1.43e-15 Developmental language disorder (linguistic errors); BRCA trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -0.84 -14.69 -0.5 2.71e-42 Hemostatic factors and hematological phenotypes; BRCA cis rs7737355 0.947 rs31240 chr5:130811146 T/A cg06307176 chr5:131281290 NA 0.52 10.38 0.38 2e-23 Life satisfaction; BRCA cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg18758796 chr5:131593413 PDLIM4 0.32 8.28 0.31 7.42e-16 Breast cancer; BRCA cis rs3845702 1.000 rs3768837 chr2:180835792 T/A cg01881094 chr2:180872142 CWC22 -0.68 -13.65 -0.48 2.08e-37 Schizophrenia; BRCA cis rs11123170 0.543 rs2166421 chr2:113990242 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.6 9.1 0.34 1.14e-18 Renal function-related traits (BUN); BRCA cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.16 -0.43 9.1e-31 Bipolar disorder; BRCA cis rs36051895 0.623 rs57707737 chr9:5062844 A/T cg02405213 chr9:5042618 JAK2 -0.53 -9.47 -0.35 5.33e-20 Pediatric autoimmune diseases; BRCA cis rs10464366 0.746 rs12670510 chr7:39142146 A/G cg18850127 chr7:39170497 POU6F2 0.48 10.31 0.38 3.76e-23 IgG glycosylation; BRCA cis rs7829975 0.582 rs6982832 chr8:8792217 A/C cg06636001 chr8:8085503 FLJ10661 -0.55 -12.06 -0.43 2.55e-30 Mood instability; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 9.36 0.35 1.36e-19 Longevity;Endometriosis; BRCA cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg10523679 chr1:76189770 ACADM 0.76 15.93 0.53 2.31e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7103648 1.000 rs7947450 chr11:47429904 G/A cg03711944 chr11:47377212 SPI1 -0.42 -11.35 -0.41 2.63e-27 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs559928 0.606 rs7941773 chr11:63952759 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.61 0.42 2.12e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs7737355 1.000 rs27708 chr5:130743541 C/T cg06307176 chr5:131281290 NA -0.49 -9.78 -0.36 3.96e-21 Life satisfaction; BRCA cis rs908922 0.676 rs6587681 chr1:152512135 C/T cg20991723 chr1:152506922 NA 0.39 9.07 0.34 1.4e-18 Hair morphology; BRCA cis rs72772090 1.000 rs72772090 chr5:96036311 G/C cg17330273 chr5:96107758 CAST;ERAP1 -0.55 -11.84 -0.42 2.24e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7631605 0.905 rs7649344 chr3:37006396 C/T cg15934958 chr3:37212084 LRRFIP2 -0.41 -9.73 -0.36 5.71e-21 Cerebrospinal P-tau181p levels; BRCA cis rs372883 0.597 rs2018956 chr21:30736622 C/A cg08807101 chr21:30365312 RNF160 0.34 7.9 0.3 1.19e-14 Pancreatic cancer; BRCA cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.59 0.52 1.15e-46 Colorectal cancer; BRCA cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg13047869 chr3:10149882 C3orf24 0.59 12.48 0.44 3.86e-32 Alzheimer's disease; BRCA cis rs7618915 0.547 rs34173654 chr3:52634605 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.0 0.4 6.75e-26 Bipolar disorder; BRCA cis rs11190604 1.000 rs11190540 chr10:102202629 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.4 0.41 1.54e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg02353165 chr6:42928485 GNMT 0.79 19.31 0.61 8.54e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6545883 0.868 rs28749199 chr2:61827052 A/G cg15711740 chr2:61764176 XPO1 -0.55 -13.25 -0.46 1.4e-35 Tuberculosis; BRCA cis rs2839627 0.561 rs4148970 chr21:44313293 A/G cg03543861 chr21:44258195 NA 0.4 8.15 0.31 1.91e-15 Information processing speed; BRCA cis rs713587 0.563 rs2384057 chr2:25100167 C/G cg04586622 chr2:25135609 ADCY3 0.4 10.4 0.38 1.58e-23 Body mass index in non-asthmatics; BRCA cis rs425277 0.958 rs262660 chr1:2086757 A/G cg00981070 chr1:2046702 PRKCZ 0.31 8.22 0.31 1.1e-15 Height; BRCA cis rs61931739 0.500 rs3924705 chr12:34557825 A/T cg06521331 chr12:34319734 NA -0.52 -10.27 -0.38 5.25e-23 Morning vs. evening chronotype; BRCA cis rs858239 0.601 rs6461693 chr7:23160133 A/G cg23682824 chr7:23144976 KLHL7 -0.42 -11.12 -0.4 2.19e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs1506636 0.962 rs1506640 chr7:123349627 T/G cg03229431 chr7:123269106 ASB15 -0.61 -14.03 -0.49 3.68e-39 Plateletcrit;Platelet count; BRCA cis rs10782582 0.545 rs12138018 chr1:76186794 T/C cg03433033 chr1:76189801 ACADM -0.51 -10.82 -0.39 3.51e-25 Daytime sleep phenotypes; BRCA trans rs2270927 0.510 rs35966882 chr5:75577716 A/G cg13563193 chr19:33072644 PDCD5 0.86 10.94 0.4 1.24e-25 Mean corpuscular volume; BRCA cis rs6546550 0.933 rs6546555 chr2:70135760 A/G cg02498382 chr2:70120550 SNRNP27 -0.52 -11.47 -0.41 7.91e-28 Prevalent atrial fibrillation; BRCA cis rs1499614 1.000 rs1638731 chr7:66144679 C/T cg18252515 chr7:66147081 NA -1.07 -15.95 -0.53 1.77e-48 Gout; BRCA cis rs9394841 0.692 rs34073739 chr6:41829970 A/G cg08135965 chr6:41755394 TOMM6 0.51 8.34 0.31 4.72e-16 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.58 -9.1 -0.34 1.18e-18 Platelet count; BRCA cis rs1468333 1.000 rs2967781 chr5:137557609 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.55 0.32 9.07e-17 Resting heart rate; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg23978390 chr7:1156363 C7orf50 0.38 9.22 0.34 4.24e-19 Longevity;Endometriosis; BRCA cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg06713675 chr4:122721982 EXOSC9 -0.55 -12.78 -0.45 1.84e-33 Type 2 diabetes; BRCA cis rs765787 0.530 rs12910270 chr15:45512086 G/A cg25801113 chr15:45476975 SHF -0.33 -8.3 -0.31 6.21e-16 Uric acid levels; BRCA cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg01483505 chr11:975446 AP2A2 0.33 9.04 0.34 1.88e-18 Alzheimer's disease (late onset); BRCA cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.59e-19 Motion sickness; BRCA cis rs908922 0.676 rs1053590 chr1:152488428 T/C cg20991723 chr1:152506922 NA 0.38 8.63 0.32 4.93e-17 Hair morphology; BRCA cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.34 0.35 1.53e-19 Parkinson's disease; BRCA cis rs6500602 0.701 rs4786500 chr16:4525265 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 -0.38 -8.17 -0.31 1.62e-15 Schizophrenia; BRCA cis rs10896135 0.526 rs484262 chr11:66399681 C/T cg24851651 chr11:66362959 CCS -0.43 -8.86 -0.33 7.67e-18 Bipolar disorder; BRCA cis rs6430585 0.528 rs75667274 chr2:136682486 C/T cg07169764 chr2:136633963 MCM6 1.27 22.58 0.67 1.9e-83 Corneal structure; BRCA cis rs7666738 0.830 rs7663438 chr4:99014582 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.05 0.3 4.07e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs853679 0.517 rs9357061 chr6:28051772 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.22e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6061231 1.000 rs13043313 chr20:60958269 A/G cg06026331 chr20:60912101 LAMA5 0.4 8.08 0.3 3.24e-15 Colorectal cancer; BRCA cis rs1008375 0.966 rs12503517 chr4:17698725 G/A cg02297831 chr4:17616191 MED28 0.36 8.29 0.31 6.84e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.54 0.42 3.95e-28 Bipolar disorder; BRCA trans rs6964833 0.786 rs35633336 chr7:74058292 G/T cg07504079 chr7:72649617 NCF1B -0.47 -9.13 -0.34 8.91e-19 Menarche (age at onset); BRCA cis rs7267979 0.868 rs6107019 chr20:25233985 C/T cg08601574 chr20:25228251 PYGB 0.42 9.78 0.36 3.85e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs875971 0.964 rs778735 chr7:65814809 C/A cg18876405 chr7:65276391 NA 0.55 13.03 0.46 1.41e-34 Aortic root size; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg05552183 chr6:42928497 GNMT 0.8 19.37 0.61 4.27e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs3815700 1.000 rs8104726 chr19:33094675 G/A cg02997394 chr19:33096574 ANKRD27 0.69 11.47 0.41 7.98e-28 Eosinophilic esophagitis; BRCA cis rs3772130 0.962 rs9878086 chr3:121488353 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.68 0.39 1.28e-24 Cognitive performance; BRCA cis rs6025261 0.761 rs6092390 chr20:55510339 C/T cg04763273 chr20:55502381 NA 0.32 7.9 0.3 1.23e-14 Verbal memory performance (delayed recall level); BRCA cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg05347473 chr6:146136440 FBXO30 0.42 8.2 0.31 1.33e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.837 rs12146734 chr12:38237079 A/G cg13010199 chr12:38710504 ALG10B 0.44 8.84 0.33 9.41e-18 Bladder cancer; BRCA cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg17063962 chr7:91808500 NA 0.52 12.27 0.44 3.04e-31 Breast cancer; BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg22920501 chr2:26401640 FAM59B 0.95 16.66 0.55 4.8e-52 Gut microbiome composition (summer); BRCA cis rs910316 0.967 rs2268619 chr14:75640354 C/G cg11812906 chr14:75593930 NEK9 -0.63 -14.44 -0.5 4.13e-41 Height; BRCA cis rs9788682 0.792 rs35031105 chr15:78772806 C/T cg24631222 chr15:78858424 CHRNA5 0.46 9.12 0.34 9.72e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg15934090 chr1:100435551 SLC35A3 0.35 8.18 0.31 1.48e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1577917 1.000 rs1857964 chr6:86635994 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.21 -0.46 2.03e-35 Response to antipsychotic treatment; BRCA cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg19729930 chr2:74357872 NA 0.59 14.58 0.5 8.99e-42 Gestational age at birth (maternal effect); BRCA cis rs7737355 0.947 rs6596029 chr5:130899079 T/C cg06307176 chr5:131281290 NA 0.53 10.44 0.38 1.18e-23 Life satisfaction; BRCA cis rs7524258 0.868 rs1304711 chr1:7270320 G/T cg07173049 chr1:7289937 CAMTA1 -0.44 -10.89 -0.4 1.81e-25 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs67311347 1.000 rs17078941 chr3:40450888 A/G cg01475735 chr3:40494733 NA 0.43 7.94 0.3 9.25e-15 Renal cell carcinoma; BRCA cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg27446573 chr6:127587934 RNF146 0.88 19.86 0.62 9.48e-69 Breast cancer; BRCA cis rs10129255 0.500 rs6576231 chr14:107191930 T/C cg07958169 chr14:107095056 NA -0.4 -8.52 -0.32 1.17e-16 Kawasaki disease; BRCA cis rs546131 0.928 rs572690 chr11:34833614 A/G cg06937548 chr11:34938143 PDHX;APIP 0.44 8.36 0.31 3.92e-16 Lung disease severity in cystic fibrosis; BRCA cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg10792982 chr14:105748885 BRF1 0.5 11.39 0.41 1.67e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs7552404 0.924 rs1858536 chr1:76161595 G/T cg10523679 chr1:76189770 ACADM 0.88 20.7 0.63 2.98e-73 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs3733585 0.699 rs7663079 chr4:9966771 T/C cg26043149 chr18:55253948 FECH -0.38 -8.35 -0.31 4.17e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4074536 0.574 rs10733095 chr1:116289164 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA trans rs57221529 0.713 rs12522724 chr5:590742 T/C cg11887960 chr12:57824829 NA 0.52 8.15 0.31 1.89e-15 Lung disease severity in cystic fibrosis; BRCA cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.74 -0.33 2.03e-17 Colorectal cancer; BRCA cis rs10870270 0.956 rs11146425 chr10:133734261 C/T cg08754478 chr10:133766260 PPP2R2D -0.69 -14.15 -0.49 9.24e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9814567 1.000 rs2056604 chr3:134312648 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg09184832 chr6:79620586 NA -0.53 -11.68 -0.42 1.05e-28 Intelligence (multi-trait analysis); BRCA cis rs920590 0.796 rs7820520 chr8:19634864 A/G cg03894339 chr8:19674705 INTS10 -0.39 -7.97 -0.3 7.14e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs2073499 1.000 rs57319506 chr3:50285677 T/C cg05260129 chr3:50388622 TUSC4;CYB561D2 0.59 8.44 0.32 2.05e-16 Schizophrenia; BRCA cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B 0.5 11.01 0.4 5.91e-26 IgG glycosylation; BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.54 7.97 0.3 7.43e-15 Cerebrospinal P-tau181p levels; BRCA trans rs1945213 0.694 rs7106894 chr11:55877315 T/C cg03929089 chr4:120376271 NA 0.57 9.83 0.36 2.59e-21 Acute lymphoblastic leukemia (childhood); BRCA cis rs4285028 0.948 rs7651226 chr3:121670802 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.76 -0.39 6.38e-25 Multiple sclerosis; BRCA cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg21132104 chr15:45694354 SPATA5L1 0.74 16.42 0.54 8.34e-51 Homoarginine levels; BRCA cis rs8072100 0.667 rs1912485 chr17:45515678 T/G cg25173405 chr17:45401733 C17orf57 -0.51 -10.59 -0.39 2.89e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs2018683 0.707 rs4722875 chr7:28969632 A/G cg19402173 chr7:128379420 CALU -0.42 -10.05 -0.37 3.77e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg24642439 chr20:33292090 TP53INP2 0.51 11.35 0.41 2.44e-27 Glomerular filtration rate (creatinine); BRCA cis rs13088281 1.000 rs13088281 chr3:53147576 A/C cg07884673 chr3:53033167 SFMBT1 -0.69 -8.54 -0.32 9.89e-17 Immune reponse to smallpox (secreted IL-2); BRCA cis rs7246657 0.551 rs4806414 chr19:37638788 T/C cg18154014 chr19:37997991 ZNF793 0.52 8.64 0.32 4.44e-17 Coronary artery calcification; BRCA trans rs4714291 0.925 rs847747 chr6:40080069 G/T cg02267698 chr19:7991119 CTXN1 0.4 7.91 0.3 1.16e-14 Strep throat; BRCA cis rs7927771 0.965 rs11039416 chr11:47846711 G/A cg18512352 chr11:47633146 NA -0.34 -8.32 -0.31 5.4e-16 Subjective well-being; BRCA cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg06675483 chr6:26987649 LOC100270746;C6orf41 -0.27 -8.06 -0.3 3.78e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs35306767 0.953 rs11253520 chr10:975961 C/G cg25019033 chr10:957182 NA 0.32 7.87 0.3 1.5e-14 Eosinophil percentage of granulocytes; BRCA trans rs9393777 0.920 rs35716472 chr6:27406607 C/G cg01620082 chr3:125678407 NA -0.73 -9.67 -0.36 9.61e-21 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs7680909 chr4:98934604 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.5 -9.59 -0.35 1.97e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4927850 0.723 rs7630825 chr3:195753740 T/C cg00031303 chr3:195681400 NA 0.5 9.57 0.35 2.33e-20 Pancreatic cancer; BRCA cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg14343924 chr8:8086146 FLJ10661 0.48 9.56 0.35 2.56e-20 Neuroticism; BRCA cis rs3008870 1.000 rs35365746 chr1:67438900 G/A cg08660285 chr1:67390436 MIER1;WDR78 -0.98 -22.05 -0.66 1.47e-80 Lymphocyte percentage of white cells; BRCA cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg27286337 chr10:134555280 INPP5A 0.85 21.38 0.65 6.66e-77 Migraine; BRCA cis rs4803455 0.565 rs11670143 chr19:41864971 A/G cg08477640 chr19:41863820 B9D2 0.39 8.13 0.31 2.15e-15 Migraine;Coronary artery disease; BRCA cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg11833968 chr6:79620685 NA 0.4 9.05 0.34 1.67e-18 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 1.000 rs72798418 chr2:24188922 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.2 0.34 5.02e-19 Lymphocyte counts; BRCA cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg08280861 chr8:58055591 NA 0.53 8.59 0.32 6.62e-17 Developmental language disorder (linguistic errors); BRCA cis rs636291 0.517 rs12565133 chr1:10544988 A/C cg17425144 chr1:10567563 PEX14 -0.54 -13.55 -0.47 6.11e-37 Prostate cancer; BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg11843238 chr5:131593191 PDLIM4 -0.38 -9.58 -0.35 2.09e-20 Acylcarnitine levels; BRCA cis rs2880765 0.835 rs7168860 chr15:86037030 G/A cg10818794 chr15:86012489 AKAP13 -0.3 -8.52 -0.32 1.17e-16 Coronary artery disease; BRCA cis rs72781680 0.898 rs116113042 chr2:23960194 G/T cg08917208 chr2:24149416 ATAD2B 0.89 12.76 0.45 2.2e-33 Lymphocyte counts; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs4664304 0.620 rs10186586 chr2:160715334 T/C cg18514922 chr2:160761262 LY75 0.33 7.9 0.3 1.21e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.95 0.43 7.46e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12887734 0.524 rs4906363 chr14:104210239 G/A cg08213375 chr14:104286397 PPP1R13B 0.51 11.02 0.4 5.78e-26 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs2070488 0.804 rs1817364 chr3:38474513 T/G cg24069376 chr3:38537580 EXOG 0.34 9.41 0.35 8.96e-20 Electrocardiographic conduction measures; BRCA cis rs708547 0.647 rs12621 chr4:57897570 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.4 10.59 0.39 2.85e-24 Response to bleomycin (chromatid breaks); BRCA cis rs490234 0.776 rs10115455 chr9:128458850 T/C cg14078157 chr9:128172775 NA -0.44 -9.85 -0.36 2.13e-21 Mean arterial pressure; BRCA cis rs757110 0.740 rs10832776 chr11:17385224 C/A cg03864215 chr11:17408437 KCNJ11 -0.26 -7.85 -0.3 1.75e-14 Type 2 diabetes; BRCA cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg10495392 chr1:46806563 NSUN4 0.47 8.7 0.33 2.71e-17 Menopause (age at onset); BRCA trans rs6089829 0.962 rs6122352 chr20:61668284 T/C cg15934090 chr1:100435551 SLC35A3 0.35 8.18 0.31 1.54e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6714710 0.603 rs55776387 chr2:98405034 T/C cg26665480 chr2:98280029 ACTR1B 0.6 13.85 0.48 2.52e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1707322 0.717 rs3014245 chr1:46086913 C/T cg06784218 chr1:46089804 CCDC17 -0.53 -12.82 -0.45 1.25e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.541 rs1414347 chr6:8471831 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.85 0.33 8.55e-18 Motion sickness; BRCA cis rs12478296 0.792 rs6738361 chr2:243014257 C/T cg18898632 chr2:242989856 NA -0.46 -7.88 -0.3 1.39e-14 Obesity-related traits; BRCA cis rs6840258 1.000 rs7695426 chr4:87921277 C/T cg08197287 chr4:87952173 AFF1 -0.45 -8.75 -0.33 1.86e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs12310956 0.515 rs115836245 chr12:33951369 T/C cg06521331 chr12:34319734 NA -0.52 -10.53 -0.38 4.89e-24 Morning vs. evening chronotype; BRCA cis rs1801251 1.000 rs6746294 chr2:233583050 C/G cg25237894 chr2:233734115 C2orf82 -0.39 -11.1 -0.4 2.62e-26 Coronary artery disease; BRCA cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg02155558 chr15:43621948 ADAL;LCMT2 0.71 12.45 0.44 5.22e-32 Lung cancer in ever smokers; BRCA cis rs10751667 0.621 rs7394862 chr11:927500 T/C cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.46e-34 Alzheimer's disease (late onset); BRCA cis rs754466 0.651 rs11815015 chr10:79625482 C/T cg17075019 chr10:79541650 NA -0.73 -17.59 -0.57 8.49e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs3741151 0.773 rs73542990 chr11:73134398 C/T cg17517138 chr11:73019481 ARHGEF17 0.93 13.14 0.46 4.36e-35 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs9814567 0.964 rs9847788 chr3:134186496 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.56 -17.8 -0.58 7.61e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs4650994 0.625 rs6681348 chr1:178526271 A/C cg05059571 chr16:84539110 KIAA1609 -0.42 -9.44 -0.35 7.1e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg25036284 chr2:26402008 FAM59B -0.79 -12.41 -0.44 7.62e-32 Gut microbiome composition (summer); BRCA cis rs875971 0.638 rs10249404 chr7:66046724 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.17 -0.31 1.69e-15 Aortic root size; BRCA cis rs79976124 0.877 rs79507557 chr6:66640908 C/A cg07460842 chr6:66804631 NA 0.6 10.31 0.38 3.59e-23 Type 2 diabetes; BRCA trans rs1005277 0.579 rs2504140 chr10:38387579 T/G cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs9837602 0.872 rs34996634 chr3:99738219 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.61 10.53 0.38 5.15e-24 Breast cancer; BRCA trans rs11098499 0.754 rs9999724 chr4:120239944 C/T cg25214090 chr10:38739885 LOC399744 0.46 10.46 0.38 9.56e-24 Corneal astigmatism; BRCA cis rs4689388 0.889 rs10026334 chr4:6294607 G/A cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs72781680 1.000 rs6751655 chr2:24155478 A/G cg08917208 chr2:24149416 ATAD2B 1.12 15.76 0.53 1.55e-47 Lymphocyte counts; BRCA cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg04450456 chr4:17643702 FAM184B 0.39 10.8 0.39 4.19e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs826838 0.651 rs1843892 chr12:38616965 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.39 0.47 3.37e-36 Heart rate; BRCA cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg03433033 chr1:76189801 ACADM 0.75 16.75 0.55 1.7e-52 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg08805041 chr16:621841 PIGQ -0.32 -8.81 -0.33 1.14e-17 Height; BRCA cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg08514558 chr10:81106712 PPIF 0.38 8.75 0.33 1.9e-17 Height; BRCA cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 12.07 0.43 2.33e-30 Tonsillectomy; BRCA cis rs6878727 0.562 rs2633527 chr5:123638706 A/G cg01806427 chr5:123737813 NA -0.37 -8.22 -0.31 1.15e-15 Breast cancer; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.0 21.9 0.65 9.17e-80 Gut microbiome composition (summer); BRCA cis rs6484504 0.625 rs796341 chr11:31414151 G/A cg26647111 chr11:31128758 NA 0.45 9.66 0.36 1.05e-20 Red blood cell count; BRCA cis rs4233802 1.000 rs4425095 chr2:151139757 C/T cg25300694 chr2:151184358 NA 0.76 8.13 0.31 2.29e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7493 0.755 rs740264 chr7:95021803 T/G cg21856205 chr7:94953877 PON1 -0.37 -7.92 -0.3 1.02e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4073582 0.595 rs528842 chr11:66032390 G/A cg16950941 chr11:66035639 RAB1B 0.46 12.3 0.44 2.24e-31 Gout; BRCA cis rs1552244 0.572 rs6442154 chr3:10168785 A/G cg00149659 chr3:10157352 C3orf10 1.06 18.02 0.58 5.43e-59 Alzheimer's disease; BRCA cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg09184832 chr6:79620586 NA -0.52 -11.51 -0.41 5.68e-28 Intelligence (multi-trait analysis); BRCA cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg11752832 chr7:134001865 SLC35B4 0.51 13.29 0.47 9.44e-36 Mean platelet volume; BRCA cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg15997130 chr1:24165203 NA 0.44 11.3 0.41 4.15e-27 Immature fraction of reticulocytes; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.36 -8.22 -0.31 1.14e-15 Longevity;Endometriosis; BRCA cis rs7474896 0.559 rs1735629 chr10:38178309 C/T cg25427524 chr10:38739819 LOC399744 0.56 10.05 0.37 3.55e-22 Obesity (extreme); BRCA cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg27535305 chr1:53392650 SCP2 0.32 8.07 0.3 3.4e-15 Monocyte count; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg06468780 chr21:31798236 KRTAP13-3 0.36 9.04 0.34 1.88e-18 HDL cholesterol; BRCA cis rs796364 1.000 rs35220450 chr2:200780737 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.78 -11.25 -0.41 6.26e-27 Schizophrenia; BRCA cis rs1595825 0.891 rs79745588 chr2:198516835 G/A cg19156104 chr2:198669113 PLCL1 -0.46 -8.57 -0.32 7.95e-17 Ulcerative colitis; BRCA cis rs1371614 0.610 rs6547317 chr2:27151919 A/G cg00617064 chr2:27272375 NA -0.31 -8.06 -0.3 3.89e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs17253792 0.822 rs78395034 chr14:56069783 G/A cg01858014 chr14:56050164 KTN1 -0.74 -9.35 -0.35 1.43e-19 Putamen volume; BRCA cis rs2688608 0.592 rs10824032 chr10:75528130 G/A cg23231163 chr10:75533350 FUT11 -0.35 -9.24 -0.34 3.57e-19 Inflammatory bowel disease; BRCA cis rs7131987 0.868 rs10771508 chr12:29414211 G/A cg09582351 chr12:29534625 ERGIC2 -0.39 -9.37 -0.35 1.26e-19 QT interval; BRCA cis rs870825 0.616 rs6818447 chr4:185650154 G/A cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs2832191 0.791 rs2832178 chr21:30479858 T/G cg08807101 chr21:30365312 RNF160 -0.62 -16.01 -0.53 9.78e-49 Dental caries; BRCA cis rs1801251 1.000 rs12474040 chr2:233615345 T/G cg08000102 chr2:233561755 GIGYF2 0.64 13.86 0.48 2.19e-38 Coronary artery disease; BRCA cis rs2637266 0.935 rs2252652 chr10:78405022 C/T cg18941641 chr10:78392320 NA 0.35 8.13 0.31 2.3e-15 Pulmonary function; BRCA cis rs867371 0.896 rs8033831 chr15:82513294 C/A cg00614314 chr15:82944287 LOC80154 0.45 9.58 0.35 2.18e-20 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs2180341 0.782 rs6912196 chr6:127722732 C/G cg24812749 chr6:127587940 RNF146 0.68 15.51 0.52 2.63e-46 Breast cancer; BRCA cis rs12762955 0.529 rs2387213 chr10:1051420 C/T cg20503657 chr10:835505 NA 0.51 8.73 0.33 2.28e-17 Response to angiotensin II receptor blocker therapy; BRCA trans rs7824557 0.767 rs2060463 chr8:11161610 T/G cg06636001 chr8:8085503 FLJ10661 0.54 10.19 0.37 1.11e-22 Retinal vascular caliber; BRCA cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg09035930 chr12:129282057 SLC15A4 -0.49 -13.87 -0.48 2.06e-38 Systemic lupus erythematosus; BRCA cis rs7107356 1 rs7107356 chr11:47676170 A/G cg20307385 chr11:47447363 PSMC3 0.5 11.87 0.43 1.67e-29 Neuroticism;Neuroticism (multi-trait analysis); BRCA cis rs6598955 0.502 rs6683157 chr1:26545865 G/A cg04990556 chr1:26633338 UBXN11 0.69 11.85 0.42 1.96e-29 Obesity-related traits; BRCA cis rs1003719 0.715 rs58008706 chr21:38540506 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -13.71 -0.48 1.05e-37 Eye color traits; BRCA cis rs4742903 0.904 rs10991187 chr9:106996271 C/T cg21169611 chr9:106856078 SMC2 0.31 8.06 0.3 3.66e-15 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.18 0.46 2.94e-35 Electroencephalogram traits; BRCA trans rs10028773 0.700 rs7690338 chr4:120256468 C/G cg25214090 chr10:38739885 LOC399744 0.46 10.59 0.39 2.85e-24 Educational attainment; BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 7.98 0.3 7e-15 Tonsillectomy; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg26516362 chr5:178986906 RUFY1 0.48 13.84 0.48 2.64e-38 Lung cancer; BRCA cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg03213289 chr20:61660250 NA 0.63 16.5 0.55 3.33e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs4268898 0.862 rs11125549 chr2:24576240 C/T cg06627628 chr2:24431161 ITSN2 0.48 9.91 0.37 1.21e-21 Asthma; BRCA cis rs4853036 0.629 rs7577864 chr2:70017435 A/G cg02498382 chr2:70120550 SNRNP27 -0.46 -8.01 -0.3 5.62e-15 Colorectal or endometrial cancer; BRCA trans rs11098499 0.954 rs12508504 chr4:120410607 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.66e-15 Corneal astigmatism; BRCA cis rs2070997 0.756 rs2987903 chr9:133711263 G/A cg11464064 chr9:133710261 ABL1 0.59 9.37 0.35 1.21e-19 Response to amphetamines; BRCA cis rs754466 0.651 rs55738779 chr10:79652395 C/T cg17075019 chr10:79541650 NA -0.72 -16.45 -0.55 6.12e-51 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10208940 0.841 rs6731066 chr2:68796618 A/G cg12452813 chr2:68675892 NA 0.5 8.82 0.33 1.09e-17 Urate levels in lean individuals; BRCA cis rs2762353 0.935 rs1165152 chr6:25818766 A/G cg12310025 chr6:25882481 NA -0.5 -12.1 -0.43 1.71e-30 Blood metabolite levels; BRCA cis rs8062405 1.000 rs62036617 chr16:28827498 T/C cg16576597 chr16:28551801 NUPR1 0.3 8.37 0.31 3.68e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6964587 0.967 rs12671991 chr7:91559481 T/C cg17063962 chr7:91808500 NA -0.52 -11.93 -0.43 8.84e-30 Breast cancer; BRCA cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg03709012 chr19:19516395 GATAD2A -0.75 -17.0 -0.56 1e-53 Tonsillectomy; BRCA cis rs10504229 1.000 rs6989060 chr8:58178989 T/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA trans rs2727020 0.734 rs1164664 chr11:49295542 T/G cg15704280 chr7:45808275 SEPT13 0.7 14.26 0.49 3.07e-40 Coronary artery disease; BRCA cis rs4285028 0.699 rs7637495 chr3:121573850 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.71 -13.28 -0.47 9.84e-36 Multiple sclerosis; BRCA cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs7572733 0.534 rs700692 chr2:198728500 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.18 0.37 1.21e-22 Dermatomyositis; BRCA cis rs11764590 0.666 rs3996325 chr7:2053747 T/C cg23422044 chr7:1970798 MAD1L1 -0.41 -8.53 -0.32 1.04e-16 Neuroticism; BRCA cis rs9443645 0.869 rs11754419 chr6:79729648 A/G cg11833968 chr6:79620685 NA -0.44 -9.85 -0.36 2.02e-21 Intelligence (multi-trait analysis); BRCA cis rs7264396 0.887 rs224370 chr20:34073379 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.39 -8.19 -0.31 1.4e-15 Total cholesterol levels; BRCA cis rs6942756 0.531 rs4731569 chr7:128930828 C/T cg02491457 chr7:128862824 NA 0.46 9.53 0.35 3.3e-20 White matter hyperintensity burden; BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg10729496 chr3:10149963 C3orf24 0.51 8.46 0.32 1.78e-16 Alzheimer's disease; BRCA cis rs17685 0.753 rs10952840 chr7:75772878 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg22907277 chr7:1156413 C7orf50 0.6 11.48 0.41 6.93e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg05340658 chr4:99064831 C4orf37 0.65 15.98 0.53 1.36e-48 Colonoscopy-negative controls vs population controls; BRCA cis rs925228 0.504 rs6729231 chr2:24292597 A/T cg01493198 chr2:24299560 SF3B14 0.56 7.81 0.3 2.4e-14 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg26384229 chr12:38710491 ALG10B 0.66 15.39 0.52 1.1e-45 Bladder cancer; BRCA cis rs6963495 0.546 rs2697020 chr7:105150046 C/T cg19920283 chr7:105172520 RINT1 0.43 8.93 0.33 4.67e-18 Bipolar disorder (body mass index interaction); BRCA cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg23711669 chr6:146136114 FBXO30 -0.79 -18.91 -0.6 1.19e-63 Lobe attachment (rater-scored or self-reported); BRCA trans rs2727020 0.729 rs10839283 chr11:49490943 T/C cg03929089 chr4:120376271 NA 0.77 17.21 0.56 7.87e-55 Coronary artery disease; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.53 8.13 0.31 2.24e-15 Renal function-related traits (BUN); BRCA cis rs3917254 0.596 rs3755294 chr2:102768376 G/A cg22835712 chr2:102737379 NA -0.5 -8.25 -0.31 9.05e-16 Blood protein levels; BRCA cis rs2624839 0.602 rs2526398 chr3:50187596 G/C cg24110177 chr3:50126178 RBM5 -0.45 -11.27 -0.41 5.34e-27 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.863 rs1480940 chr4:120457682 T/C cg25214090 chr10:38739885 LOC399744 0.57 12.45 0.44 5.24e-32 Corneal astigmatism; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg18402987 chr7:1209562 NA 0.61 12.52 0.44 2.58e-32 Longevity;Endometriosis; BRCA cis rs7666738 0.712 rs11731393 chr4:98859070 G/C cg17366294 chr4:99064904 C4orf37 0.49 8.41 0.32 2.75e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg23583168 chr7:148888333 NA -0.76 -16.44 -0.55 6.73e-51 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10782582 0.569 rs1770892 chr1:76389359 T/C cg03433033 chr1:76189801 ACADM -0.39 -7.98 -0.3 6.57e-15 Daytime sleep phenotypes; BRCA cis rs2832191 0.933 rs2832236 chr21:30547602 C/T cg24692254 chr21:30365293 RNF160 -0.59 -14.72 -0.5 1.9e-42 Dental caries; BRCA cis rs7512552 0.809 rs9436108 chr1:150360930 A/G cg15654264 chr1:150340011 RPRD2 0.38 8.4 0.32 2.96e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs490234 0.702 rs3814129 chr9:128365953 A/G cg14078157 chr9:128172775 NA -0.43 -9.85 -0.36 2.02e-21 Mean arterial pressure; BRCA cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.69 14.82 0.51 6.58e-43 Multiple sclerosis; BRCA cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.21 0.58 5.05e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs6142102 0.580 rs761233 chr20:32568886 A/G cg24642439 chr20:33292090 TP53INP2 0.39 7.83 0.3 2.1e-14 Skin pigmentation; BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg05552183 chr6:42928497 GNMT -0.81 -18.93 -0.6 8.91e-64 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg04586622 chr2:25135609 ADCY3 0.45 11.5 0.41 6.04e-28 Body mass index in non-asthmatics; BRCA cis rs1864400 0.690 rs7098237 chr10:43740513 T/A cg15436174 chr10:43711423 RASGEF1A 0.5 9.97 0.37 7.18e-22 Hirschsprung disease; BRCA cis rs11608355 0.545 rs12822974 chr12:109909154 G/T cg05360138 chr12:110035743 NA 0.71 13.09 0.46 7.36e-35 Neuroticism; BRCA cis rs713587 0.525 rs11675457 chr2:25079770 C/T cg04586622 chr2:25135609 ADCY3 0.42 11.07 0.4 3.61e-26 Body mass index in non-asthmatics; BRCA cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg08807101 chr21:30365312 RNF160 -0.55 -13.43 -0.47 2.08e-36 Dental caries; BRCA cis rs2549003 1.000 rs2070731 chr5:131819798 T/C cg02551604 chr5:131831745 NA -0.39 -13.73 -0.48 8.48e-38 Asthma (sex interaction); BRCA cis rs7246657 0.943 rs13343502 chr19:37962292 C/T cg23950597 chr19:37808831 NA -0.75 -13.2 -0.46 2.34e-35 Coronary artery calcification; BRCA cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg04317338 chr11:64019027 PLCB3 0.56 9.68 0.36 9.17e-21 Mean platelet volume; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg09263875 chr16:632152 PIGQ 0.72 21.6 0.65 4.29e-78 Height; BRCA cis rs6088580 0.524 rs6088569 chr20:33268199 G/A cg24642439 chr20:33292090 TP53INP2 -0.42 -8.64 -0.32 4.42e-17 Glomerular filtration rate (creatinine); BRCA cis rs9467773 0.609 rs12663780 chr6:26397573 T/C cg09904177 chr6:26538194 HMGN4 -0.36 -9.35 -0.35 1.42e-19 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg05347473 chr6:146136440 FBXO30 -0.43 -8.43 -0.32 2.33e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs875971 1.000 rs6958484 chr7:65599446 G/A cg12463550 chr7:65579703 CRCP -0.37 -7.96 -0.3 8.11e-15 Aortic root size; BRCA cis rs4730250 0.634 rs11767623 chr7:106792332 C/T cg02696742 chr7:106810147 HBP1 0.57 9.43 0.35 7.51e-20 Osteoarthritis; BRCA cis rs67981189 0.865 rs2189806 chr14:71388398 T/A cg15816911 chr14:71606274 NA -0.37 -8.25 -0.31 9.14e-16 Schizophrenia; BRCA cis rs600806 0.778 rs4970765 chr1:110009171 C/T cg20591472 chr1:110008990 SYPL2 0.31 7.98 0.3 6.93e-15 Intelligence (multi-trait analysis); BRCA trans rs7618501 0.633 rs7621026 chr3:49975334 A/G cg21659725 chr3:3221576 CRBN 0.46 11.56 0.42 3.34e-28 Intelligence (multi-trait analysis); BRCA trans rs9329221 0.506 rs6993610 chr8:10330994 C/G cg15556689 chr8:8085844 FLJ10661 -0.35 -8.85 -0.33 8.85e-18 Neuroticism; BRCA cis rs36051895 0.695 rs10124627 chr9:5025746 T/G cg02405213 chr9:5042618 JAK2 -0.46 -8.56 -0.32 8.48e-17 Pediatric autoimmune diseases; BRCA cis rs6582630 0.576 rs2387837 chr12:38403164 G/T cg26384229 chr12:38710491 ALG10B -0.42 -9.88 -0.36 1.65e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg13770153 chr20:60521292 NA -0.39 -9.41 -0.35 8.96e-20 Body mass index; BRCA cis rs977987 0.806 rs11862582 chr16:75431295 T/C cg03315344 chr16:75512273 CHST6 0.54 12.72 0.45 3.26e-33 Dupuytren's disease; BRCA cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.46 10.45 0.38 1.08e-23 Aortic root size; BRCA cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg24675658 chr1:53192096 ZYG11B -0.52 -11.57 -0.42 2.99e-28 Monocyte count; BRCA trans rs3733585 0.673 rs4314284 chr4:9956096 C/T cg26043149 chr18:55253948 FECH -0.38 -8.44 -0.32 2.1e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg13010199 chr12:38710504 ALG10B -0.41 -9.59 -0.35 2e-20 Heart rate; BRCA cis rs7584330 0.657 rs7599658 chr2:238352898 A/C cg14458575 chr2:238380390 NA -0.56 -12.86 -0.45 8.38e-34 Prostate cancer; BRCA cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg14440974 chr22:39074834 NA -0.38 -9.13 -0.34 8.96e-19 Menopause (age at onset); BRCA cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.66 -0.32 3.76e-17 Aortic root size; BRCA cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg03188948 chr7:1209495 NA 0.51 8.56 0.32 8.1e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg25319279 chr11:5960081 NA -0.43 -8.4 -0.32 3e-16 DNA methylation (variation); BRCA cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg04317338 chr11:64019027 PLCB3 0.55 9.52 0.35 3.59e-20 Mean platelet volume; BRCA cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg23649088 chr2:200775458 C2orf69 -0.61 -7.94 -0.3 9.36e-15 Schizophrenia; BRCA cis rs9487051 0.872 rs9386789 chr6:109603218 A/G cg12927641 chr6:109611667 NA -0.41 -10.63 -0.39 2.12e-24 Reticulocyte fraction of red cells; BRCA cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg14019146 chr3:50243930 SLC38A3 0.36 8.78 0.33 1.46e-17 Body mass index; BRCA cis rs11252926 0.966 rs11252923 chr10:566195 G/A cg18196295 chr10:418757 DIP2C -0.46 -9.56 -0.35 2.57e-20 Psychosis in Alzheimer's disease; BRCA trans rs2204008 0.641 rs66876045 chr12:38205713 G/A cg06521331 chr12:34319734 NA -0.5 -9.31 -0.35 1.97e-19 Bladder cancer; BRCA cis rs514406 0.929 rs564273 chr1:53332445 G/C cg08859206 chr1:53392774 SCP2 -0.51 -10.85 -0.39 2.71e-25 Monocyte count; BRCA cis rs3862260 0.509 rs1045827 chr1:120162442 C/T cg11530693 chr1:120165357 ZNF697 -0.58 -13.67 -0.48 1.74e-37 Systemic lupus erythematosus; BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.74 0.39 7.82e-25 Tonsillectomy; BRCA cis rs6815814 0.950 rs11722788 chr4:38810738 C/G cg06935464 chr4:38784597 TLR10 0.51 8.4 0.32 2.88e-16 Breast cancer; BRCA cis rs7666738 0.830 rs35752787 chr4:98935202 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9733 0.596 rs6681990 chr1:150695929 A/G cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs7666738 0.830 rs58367603 chr4:99015350 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg21644426 chr2:191273491 MFSD6 -0.43 -10.95 -0.4 1.06e-25 Pulse pressure; BRCA cis rs7927592 0.871 rs12360903 chr11:68236314 C/A cg20283391 chr11:68216788 NA -0.47 -9.15 -0.34 7.86e-19 Total body bone mineral density; BRCA cis rs6878727 0.813 rs10063748 chr5:123704134 T/C cg01806427 chr5:123737813 NA 0.42 8.65 0.32 4.29e-17 Breast cancer; BRCA cis rs9394159 0.583 rs6457738 chr6:33617464 C/T cg14003231 chr6:33640908 ITPR3 -0.4 -10.07 -0.37 3.07e-22 Graves' disease; BRCA cis rs9875589 0.509 rs2607757 chr3:14081948 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 -0.33 -8.72 -0.33 2.41e-17 Ovarian reserve; BRCA cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg08000102 chr2:233561755 GIGYF2 -0.63 -13.77 -0.48 5.96e-38 Coronary artery disease; BRCA cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg11941060 chr3:133502564 NA -0.5 -11.73 -0.42 6.6e-29 Iron status biomarkers; BRCA cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg06784218 chr1:46089804 CCDC17 -0.45 -10.77 -0.39 5.85e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6840360 0.593 rs1877186 chr4:152692418 C/G cg22705602 chr4:152727874 NA -0.38 -10.51 -0.38 6.35e-24 Intelligence (multi-trait analysis); BRCA cis rs6598955 0.671 rs12141563 chr1:26589636 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs8031584 0.918 rs61997139 chr15:31273602 C/G cg08704250 chr15:31115839 NA -0.34 -8.58 -0.32 7.26e-17 Huntington's disease progression; BRCA cis rs1475911 0.708 rs56109792 chr21:43520060 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 -0.57 -12.33 -0.44 1.74e-31 IgG glycosylation; BRCA cis rs9287719 0.934 rs6721510 chr2:10751046 T/C cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.45e-23 Prostate cancer; BRCA cis rs4820539 1.000 rs3827316 chr22:23468538 T/C cg14186256 chr22:23484241 RTDR1 0.76 22.61 0.67 1.31e-83 Bone mineral density; BRCA cis rs9527 0.590 rs7897663 chr10:104905604 T/C cg04362960 chr10:104952993 NT5C2 0.46 10.73 0.39 8.24e-25 Arsenic metabolism; BRCA cis rs2294693 0.947 rs9369254 chr6:40989408 T/C cg14418226 chr6:40996092 UNC5CL 0.45 8.3 0.31 6.16e-16 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs651907 0.617 rs797776 chr3:101610243 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.36 9.08 0.34 1.39e-18 Colorectal cancer; BRCA cis rs7607369 0.536 rs6436089 chr2:219668813 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.16 -0.37 1.4e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs8103278 0.507 rs7246377 chr19:46292259 G/A cg20908204 chr19:46285434 DMPK 0.29 8.94 0.33 4.14e-18 Coronary artery disease; BRCA trans rs931812 0.757 rs4734492 chr8:101901901 C/T cg20993868 chr7:22813445 NA -0.43 -12.96 -0.46 2.87e-34 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs7617480 0.519 rs6790914 chr3:49206318 G/C cg07636037 chr3:49044803 WDR6 0.79 18.81 0.6 3.72e-63 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs1862618 0.853 rs3099459 chr5:56137170 G/C cg12311346 chr5:56204834 C5orf35 -0.81 -16.07 -0.54 4.6e-49 Initial pursuit acceleration; BRCA trans rs208520 0.690 rs207081 chr6:66773742 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.39 -0.65 5.51e-77 Exhaled nitric oxide output; BRCA cis rs7927771 1.000 rs7927771 chr11:47781306 A/G cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs11764590 0.694 rs55860148 chr7:2105594 G/A cg02743256 chr7:2109353 MAD1L1 -0.4 -7.97 -0.3 7.25e-15 Neuroticism; BRCA cis rs4805272 0.626 rs6509072 chr19:29331703 C/G cg04546413 chr19:29218101 NA 0.46 9.52 0.35 3.59e-20 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs2153535 0.580 rs6912193 chr6:8456306 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs4653767 1.000 rs708773 chr1:226920730 T/C cg05049329 chr1:226924846 ITPKB 0.34 9.54 0.35 2.96e-20 Parkinson's disease; BRCA cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg11752832 chr7:134001865 SLC35B4 0.49 12.5 0.44 3.17e-32 Mean platelet volume; BRCA cis rs919433 0.617 rs700645 chr2:198605514 A/G cg00792783 chr2:198669748 PLCL1 0.46 9.93 0.37 1.06e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg04450456 chr4:17643702 FAM184B -0.33 -9.46 -0.35 5.74e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg01262667 chr19:19385393 TM6SF2 0.42 10.97 0.4 9.28e-26 Tonsillectomy; BRCA cis rs6484504 0.532 rs12222329 chr11:31274340 T/C cg14844989 chr11:31128820 NA -0.45 -9.65 -0.36 1.18e-20 Red blood cell count; BRCA cis rs754466 1.000 rs67059283 chr10:79683235 C/T cg17075019 chr10:79541650 NA -0.68 -12.85 -0.45 8.95e-34 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg26119090 chr2:26468346 HADHA;HADHB -0.65 -13.25 -0.46 1.39e-35 Gut microbiome composition (summer); BRCA cis rs6546550 0.901 rs13015457 chr2:70125763 G/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.53 -0.41 4.52e-28 Prevalent atrial fibrillation; BRCA cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs7662987 0.517 rs2851260 chr4:100033574 C/T cg13256891 chr4:100009986 ADH5 0.53 9.77 0.36 4.33e-21 Smoking initiation; BRCA cis rs3806843 0.735 rs3776129 chr5:140072292 G/A cg26395211 chr5:140044315 WDR55 0.37 8.52 0.32 1.16e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg24531977 chr5:56204891 C5orf35 -0.86 -18.04 -0.58 4.05e-59 Initial pursuit acceleration; BRCA cis rs11190604 1.000 rs1417823 chr10:102227886 C/T cg07080220 chr10:102295463 HIF1AN -0.5 -11.96 -0.43 6.65e-30 Palmitoleic acid (16:1n-7) levels; BRCA cis rs372883 0.624 rs1153286 chr21:30684383 A/G cg24692254 chr21:30365293 RNF160 -0.37 -8.56 -0.32 8.66e-17 Pancreatic cancer; BRCA cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg05623727 chr3:50126028 RBM5 0.48 11.83 0.42 2.45e-29 Intelligence (multi-trait analysis); BRCA cis rs6763687 0.611 rs4894806 chr3:171818000 G/A cg16233210 chr3:171778391 FNDC3B 0.4 9.16 0.34 7.17e-19 Red cell distribution width; BRCA cis rs4148883 0.545 rs17595102 chr4:99986316 C/G cg13256891 chr4:100009986 ADH5 0.4 8.55 0.32 9.39e-17 Alcohol dependence; BRCA cis rs965469 0.553 rs6051767 chr20:3324521 C/T cg25506879 chr20:3388711 C20orf194 -0.41 -8.51 -0.32 1.24e-16 IFN-related cytopenia; BRCA cis rs7945705 0.902 rs7479407 chr11:9023421 C/T cg12365402 chr11:9010492 NRIP3 0.44 9.61 0.36 1.59e-20 Hemoglobin concentration; BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg00814883 chr7:100076585 TSC22D4 -0.49 -9.95 -0.37 8.76e-22 Platelet count; BRCA cis rs7394190 0.748 rs4082339 chr10:75539812 C/T cg07699608 chr10:75541558 CHCHD1 -0.58 -8.71 -0.33 2.65e-17 Incident atrial fibrillation; BRCA cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs7246657 0.943 rs10420754 chr19:37959372 C/G cg23950597 chr19:37808831 NA -0.62 -11.51 -0.41 5.55e-28 Coronary artery calcification; BRCA cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg04450456 chr4:17643702 FAM184B 0.33 9.49 0.35 4.69e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35661897 0.920 rs12469727 chr2:227301483 A/G cg03426602 chr2:227312417 NA 0.52 8.76 0.33 1.7e-17 Urinary tract infection frequency; BRCA cis rs2836974 0.965 rs7354783 chr21:40652992 G/A cg11890956 chr21:40555474 PSMG1 1.04 29.41 0.76 7.29e-121 Cognitive function; BRCA cis rs7301826 0.627 rs7978987 chr12:131281494 G/A cg11011512 chr12:131303247 STX2 -0.46 -11.36 -0.41 2.19e-27 Plasma plasminogen activator levels; BRCA cis rs875971 1.000 rs10257427 chr7:65743208 T/C cg18876405 chr7:65276391 NA -0.55 -13.32 -0.47 6.66e-36 Aortic root size; BRCA cis rs1707322 0.721 rs10789471 chr1:46215619 G/A cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7726839 0.561 rs11955068 chr5:582324 C/T cg25482853 chr8:67687455 SGK3 0.79 13.14 0.46 4.28e-35 Obesity-related traits; BRCA cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg09184832 chr6:79620586 NA -0.53 -11.87 -0.42 1.6800000000000001e-29 Intelligence (multi-trait analysis); BRCA cis rs4478858 0.647 rs10798836 chr1:31709214 C/T cg00250761 chr1:31883323 NA -0.31 -8.18 -0.31 1.49e-15 Alcohol dependence; BRCA cis rs9463078 0.616 rs2211393 chr6:44716366 A/C cg25276700 chr6:44698697 NA 0.37 8.57 0.32 7.53e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs12477438 0.520 rs2516835 chr2:99779131 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA trans rs911555 0.723 rs4906324 chr14:103923099 A/G cg17675199 chr6:35436792 RPL10A -0.3 -8.05 -0.3 3.9e-15 Intelligence (multi-trait analysis); BRCA cis rs61990749 0.597 rs12887282 chr14:78200585 C/A cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.91 0.3 1.15e-14 Fibroblast growth factor basic levels; BRCA cis rs9914988 0.943 rs9907178 chr17:27124307 G/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.79 -0.33 1.37e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs7301826 0.651 rs4759519 chr12:131289508 G/A cg11011512 chr12:131303247 STX2 0.51 13.6 0.47 3.4e-37 Plasma plasminogen activator levels; BRCA cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg08917208 chr2:24149416 ATAD2B 1.02 13.65 0.48 1.97e-37 Lymphocyte counts; BRCA cis rs55882075 0.808 rs6867806 chr5:179179585 C/G cg14593053 chr5:179126677 CANX 0.4 10.05 0.37 3.83e-22 Monocyte percentage of white cells; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg03188948 chr7:1209495 NA 0.69 15.29 0.52 3.49e-45 Longevity;Endometriosis; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00149659 chr3:10157352 C3orf10 0.71 12.54 0.44 2.2e-32 Alzheimer's disease; BRCA cis rs6981523 0.553 rs11783890 chr8:11056388 T/C cg21775007 chr8:11205619 TDH -0.48 -8.88 -0.33 6.53e-18 Neuroticism; BRCA trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.92 -0.66 7.62e-80 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs13138920 chr4:99020786 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs16854884 0.657 rs920159 chr3:143753194 A/T cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA cis rs4808199 0.948 rs7259434 chr19:19428805 A/T cg03709012 chr19:19516395 GATAD2A 0.9 17.31 0.57 2.34e-55 Nonalcoholic fatty liver disease; BRCA cis rs708547 0.575 rs6847086 chr4:57791864 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.41 -10.65 -0.39 1.68e-24 Response to bleomycin (chromatid breaks); BRCA cis rs4077515 0.577 rs10870165 chr9:139316601 C/T cg14019695 chr9:139328340 INPP5E 0.39 10.35 0.38 2.52e-23 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7666738 0.791 rs10856934 chr4:99010844 A/G cg17366294 chr4:99064904 C4orf37 -0.45 -10.52 -0.38 5.51e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10044254 0.724 rs4702108 chr5:15780376 G/C cg07238450 chr5:15720153 FBXL7 0.37 7.84 0.3 1.94e-14 Asthma (corticosteroid response); BRCA trans rs35110281 0.693 rs3819161 chr21:45092653 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.22 0.31 1.16e-15 Mean corpuscular volume; BRCA trans rs6479891 1.000 rs16918573 chr10:65300805 T/A cg14819942 chr15:35414228 NA 0.34 8.25 0.31 9.01e-16 Arthritis (juvenile idiopathic); BRCA cis rs9283706 0.608 rs12523505 chr5:66334631 C/T cg11590213 chr5:66331682 MAST4 0.38 7.98 0.3 6.69e-15 Coronary artery disease; BRCA cis rs11098499 0.820 rs13122709 chr4:120555356 T/A cg09307838 chr4:120376055 NA 0.68 13.72 0.48 9.37e-38 Corneal astigmatism; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg00149659 chr3:10157352 C3orf10 0.68 12.05 0.43 2.79e-30 Alzheimer's disease; BRCA cis rs861020 0.771 rs674804 chr1:210014603 C/G cg05527609 chr1:210001259 C1orf107 0.83 18.96 0.6 6.42e-64 Orofacial clefts; BRCA cis rs17345786 0.906 rs11710016 chr3:101120030 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.6 -11.42 -0.41 1.29e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg18402987 chr7:1209562 NA 0.88 14.46 0.5 3.5e-41 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs61008539 0.893 rs11765528 chr7:861952 C/T cg07138768 chr7:917805 C7orf20 0.29 8.4 0.32 2.85e-16 Perceived unattractiveness to mosquitoes; BRCA trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg04842962 chr6:43655489 MRPS18A 1.01 22.8 0.67 1.25e-84 IgG glycosylation; BRCA cis rs992157 0.835 rs10932769 chr2:219147245 T/G cg00012203 chr2:219082015 ARPC2 -0.47 -9.2 -0.34 5.2e-19 Colorectal cancer; BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26314531 chr2:26401878 FAM59B -0.79 -12.6 -0.45 1.18e-32 Gut microbiome composition (summer); BRCA cis rs1113500 0.933 rs61797344 chr1:108622580 C/T cg06207961 chr1:108661230 NA 0.45 11.09 0.4 2.99e-26 Growth-regulated protein alpha levels; BRCA cis rs6598955 0.671 rs12088858 chr1:26643708 C/A cg04990556 chr1:26633338 UBXN11 0.54 8.87 0.33 7.24e-18 Obesity-related traits; BRCA cis rs2243480 0.901 rs57126451 chr7:65416306 T/C cg18252515 chr7:66147081 NA -0.83 -12.11 -0.43 1.56e-30 Diabetic kidney disease; BRCA cis rs2836974 0.931 rs2776309 chr21:40715791 A/G cg11644478 chr21:40555479 PSMG1 0.75 15.79 0.53 1.17e-47 Cognitive function; BRCA cis rs9815354 0.767 rs111708447 chr3:41809583 G/A cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs10193935 0.901 rs222483 chr2:42652184 T/G cg27598129 chr2:42591480 NA -0.81 -13.74 -0.48 7.65e-38 Colonoscopy-negative controls vs population controls; BRCA cis rs611744 0.647 rs631775 chr8:109252746 T/C cg21045802 chr8:109455806 TTC35 0.35 8.08 0.3 3.25e-15 Dupuytren's disease; BRCA cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg03517284 chr6:25882590 NA -0.36 -8.28 -0.31 7.44e-16 Height; BRCA cis rs9393692 0.905 rs1125000 chr6:26287256 C/T cg13736514 chr6:26305472 NA -0.36 -12.1 -0.43 1.67e-30 Educational attainment; BRCA cis rs9733 0.791 rs11204693 chr1:150647987 C/T cg13175981 chr1:150552382 MCL1 0.46 10.34 0.38 2.76e-23 Tonsillectomy; BRCA trans rs9650657 0.537 rs11250092 chr8:10786543 A/G cg15556689 chr8:8085844 FLJ10661 0.36 9.59 0.35 2.01e-20 Neuroticism; BRCA cis rs490234 0.756 rs10986849 chr9:128469683 A/G cg14078157 chr9:128172775 NA -0.39 -8.77 -0.33 1.58e-17 Mean arterial pressure; BRCA cis rs2652822 0.525 rs11634159 chr15:63507422 C/T cg02713581 chr15:63449717 RPS27L 0.41 8.31 0.31 5.92e-16 Metabolic traits; BRCA cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs2370759 1.000 rs11599522 chr10:32568434 G/C cg01819863 chr10:32635814 EPC1 1.13 19.97 0.62 2.46e-69 Sexual dysfunction (female); BRCA cis rs782590 0.818 rs2627765 chr2:55883317 G/T cg18811423 chr2:55921094 PNPT1 0.71 22.55 0.67 2.72e-83 Metabolic syndrome; BRCA cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg18230493 chr5:56204884 C5orf35 -0.44 -8.9 -0.33 5.74e-18 Coronary artery disease; BRCA cis rs12701220 0.504 rs12702092 chr7:1145868 G/A cg04025307 chr7:1156635 C7orf50 0.44 8.27 0.31 7.82e-16 Bronchopulmonary dysplasia; BRCA cis rs9487051 0.768 rs458740 chr6:109525527 C/T cg21918786 chr6:109611834 NA -0.34 -9.05 -0.34 1.68e-18 Reticulocyte fraction of red cells; BRCA cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg05340658 chr4:99064831 C4orf37 0.58 11.81 0.42 2.88e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs9300255 0.602 rs1617434 chr12:123649486 A/G cg05973401 chr12:123451056 ABCB9 0.42 7.98 0.3 7.04e-15 Neutrophil percentage of white cells; BRCA cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg23711669 chr6:146136114 FBXO30 0.72 17.59 0.57 8.45e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg13256891 chr4:100009986 ADH5 -0.4 -9.32 -0.35 1.82e-19 Alcohol dependence; BRCA cis rs4689592 0.546 rs2359012 chr4:7066053 A/C cg26116260 chr4:7069785 GRPEL1 0.94 27.7 0.74 1.52e-111 Monocyte percentage of white cells; BRCA cis rs17601876 0.814 rs8039089 chr15:51561328 T/G cg19946085 chr15:51559439 CYP19A1 -0.39 -11.62 -0.42 1.87e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7631605 0.935 rs4647218 chr3:37042082 A/G cg15934958 chr3:37212084 LRRFIP2 0.41 9.57 0.35 2.38e-20 Cerebrospinal P-tau181p levels; BRCA cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg24642439 chr20:33292090 TP53INP2 -0.41 -8.21 -0.31 1.23e-15 Height; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.86 -16.51 -0.55 2.75e-51 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 0.515 rs67342818 chr3:10166406 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs9368481 0.761 rs9348746 chr6:26970357 C/G cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.33 -10.72 -0.39 9.2e-25 Autism spectrum disorder or schizophrenia; BRCA cis rs4363385 0.588 rs7540609 chr1:153024589 C/A cg25856811 chr1:152973957 SPRR3 -0.31 -8.0 -0.3 6.06e-15 Inflammatory skin disease; BRCA cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg22117172 chr7:91764530 CYP51A1 0.24 8.14 0.31 2.01e-15 Breast cancer; BRCA cis rs7512552 0.809 rs9436112 chr1:150406449 A/C cg15654264 chr1:150340011 RPRD2 0.37 8.16 0.31 1.76e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs13064411 0.696 rs6799610 chr3:113248748 A/C cg18753928 chr3:113234510 CCDC52 0.56 11.65 0.42 1.44e-28 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs10465746 0.570 rs11163884 chr1:84472760 A/G cg10977910 chr1:84465055 TTLL7 0.54 11.08 0.4 3.22e-26 Obesity-related traits; BRCA cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg11279151 chr3:101281821 RG9MTD1 -0.59 -14.3 -0.49 1.94e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs34779708 0.931 rs35886556 chr10:35334985 C/T cg03585969 chr10:35415529 CREM 0.55 11.39 0.41 1.72e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs8103278 0.826 rs11669442 chr19:46374557 A/G cg14061069 chr19:46274453 DMPK -0.42 -10.01 -0.37 5.06e-22 Coronary artery disease; BRCA cis rs7264396 0.563 rs2050729 chr20:34294409 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.68 12.06 0.43 2.64e-30 Total cholesterol levels; BRCA cis rs7264396 0.580 rs6060648 chr20:34456704 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.65 -11.99 -0.43 4.86e-30 Total cholesterol levels; BRCA cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg14993813 chr1:46806288 NSUN4 0.48 9.22 0.34 4.19e-19 Menopause (age at onset); BRCA cis rs775227 0.574 rs35274817 chr3:113266391 A/G cg18753928 chr3:113234510 CCDC52 -0.57 -9.66 -0.36 1.08e-20 Dental caries; BRCA cis rs4594175 0.926 rs4617765 chr14:51598843 T/C cg23942311 chr14:51606299 NA 0.34 8.47 0.32 1.72e-16 Cancer; BRCA cis rs4919087 1.000 rs4919087 chr10:99072507 C/T cg25902810 chr10:99078978 FRAT1 -0.53 -11.96 -0.43 7.01e-30 Monocyte count; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg26516362 chr5:178986906 RUFY1 0.44 12.41 0.44 7.61e-32 Lung cancer; BRCA cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.36 -13.48 -0.47 1.2e-36 Autism spectrum disorder or schizophrenia; BRCA cis rs12310956 0.532 rs7967627 chr12:33974669 G/T cg06521331 chr12:34319734 NA -0.57 -11.15 -0.4 1.71e-26 Morning vs. evening chronotype; BRCA trans rs35110281 0.667 rs4819287 chr21:45120147 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.04 0.3 4.39e-15 Mean corpuscular volume; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg07092213 chr7:1199455 ZFAND2A -0.51 -11.0 -0.4 7.06e-26 Longevity;Endometriosis; BRCA cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg06618935 chr21:46677482 NA -0.37 -8.24 -0.31 9.65e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg20848291 chr7:100343083 ZAN 0.36 8.15 0.31 1.87e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs1467026 0.584 rs11712581 chr3:12807781 T/C cg24848339 chr3:12840334 CAND2 0.39 9.82 0.36 2.74e-21 P wave duration; BRCA cis rs2304069 0.954 rs6861548 chr5:149384680 A/G cg10852222 chr5:149380144 HMGXB3;TIGD6 0.56 8.73 0.33 2.29e-17 HIV-1 control; BRCA cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs208520 0.690 rs851458 chr6:66813279 T/G cg07460842 chr6:66804631 NA -1.0 -20.09 -0.62 5.77e-70 Exhaled nitric oxide output; BRCA cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg23205692 chr1:25664452 TMEM50A 0.41 9.8 0.36 3.21e-21 Erythrocyte sedimentation rate; BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg05863683 chr7:1912471 MAD1L1 0.36 8.3 0.31 6.21e-16 Bipolar disorder and schizophrenia; BRCA cis rs7617773 0.780 rs11714944 chr3:48366971 C/A cg11946769 chr3:48343235 NME6 0.67 13.64 0.47 2.37e-37 Coronary artery disease; BRCA trans rs11098499 0.954 rs13151285 chr4:120314741 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs782590 0.643 rs13009906 chr2:55739434 A/G cg18811423 chr2:55921094 PNPT1 -0.51 -13.18 -0.46 3.06e-35 Metabolic syndrome; BRCA cis rs9296092 0.517 rs9461876 chr6:33516657 C/T cg13560919 chr6:33536144 NA -0.83 -16.87 -0.56 4.55e-53 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs12367572 0.601 rs10880730 chr12:45422443 G/A cg04608330 chr12:45269318 NELL2 -0.46 -10.05 -0.37 3.77e-22 Gut microbiome composition (summer); BRCA cis rs61990749 0.597 rs6574391 chr14:78208121 G/A cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.85 0.36 2.06e-21 Fibroblast growth factor basic levels; BRCA cis rs6866344 0.697 rs58549512 chr5:178133204 C/T cg03877680 chr5:178157825 ZNF354A 0.78 14.54 0.5 1.38e-41 Neutrophil percentage of white cells; BRCA cis rs10504229 1.000 rs61733801 chr8:58192513 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs28374715 0.532 rs7168431 chr15:41672384 A/G cg18705301 chr15:41695430 NDUFAF1 -1.09 -24.82 -0.7 9.65e-96 Ulcerative colitis; BRCA cis rs2032447 0.966 rs9358901 chr6:26024436 G/T cg12310025 chr6:25882481 NA -0.43 -10.04 -0.37 3.87e-22 Intelligence (multi-trait analysis); BRCA trans rs11039798 0.698 rs78553793 chr11:48947336 C/A cg15704280 chr7:45808275 SEPT13 0.66 7.91 0.3 1.11e-14 Axial length; BRCA cis rs243505 1.000 rs243519 chr7:148423624 G/A cg09806900 chr7:148480153 CUL1 -0.4 -8.39 -0.31 3.16e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 18.59 0.59 5.56e-62 Alzheimer's disease; BRCA cis rs11724804 0.532 rs62297079 chr4:879977 G/A cg20916646 chr4:852691 GAK 0.5 10.97 0.4 8.84e-26 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; BRCA cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg14019146 chr3:50243930 SLC38A3 0.37 9.18 0.34 6.06e-19 Body mass index; BRCA cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg25801113 chr15:45476975 SHF 0.31 7.84 0.3 1.83e-14 Uric acid levels; BRCA cis rs12530845 0.623 rs7798256 chr7:135344211 C/A cg23117316 chr7:135346802 PL-5283 -0.41 -8.31 -0.31 5.82e-16 Red blood cell traits; BRCA cis rs10927875 0.541 rs1763607 chr1:16337509 G/A cg06159980 chr1:16340746 HSPB7 -0.39 -9.04 -0.34 1.89e-18 Dilated cardiomyopathy; BRCA cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg25554036 chr4:6271136 WFS1 0.42 9.97 0.37 7.45e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9469578 0.710 rs77213792 chr6:33713952 C/G cg18708504 chr6:33715942 IP6K3 0.7 10.18 0.37 1.12e-22 Phosphorus levels; BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg13628971 chr7:2884303 GNA12 0.46 9.09 0.34 1.25e-18 Height; BRCA cis rs7618915 0.501 rs9917834 chr3:52634619 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.49 0.41 6.46e-28 Bipolar disorder; BRCA cis rs7100689 0.646 rs2486302 chr10:82076600 G/A cg01528321 chr10:82214614 TSPAN14 0.81 17.1 0.56 2.94e-54 Post bronchodilator FEV1; BRCA cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg26597838 chr10:835615 NA 1.04 18.42 0.59 4.13e-61 Eosinophil percentage of granulocytes; BRCA cis rs4906332 1.000 rs3783397 chr14:103947289 A/G cg19000871 chr14:103996768 TRMT61A -0.35 -8.11 -0.31 2.65e-15 Coronary artery disease; BRCA cis rs2991971 1.000 rs9147 chr1:46016687 T/C cg24296786 chr1:45957014 TESK2 0.62 15.49 0.52 3.63e-46 High light scatter reticulocyte count; BRCA cis rs10876993 0.928 rs1689586 chr12:58079586 A/T cg18357645 chr12:58087776 OS9 0.48 13.81 0.48 3.69e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs1707322 0.721 rs10789468 chr1:46124558 A/G cg03146154 chr1:46216737 IPP 0.47 10.51 0.38 6.17e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7615952 0.512 rs34651730 chr3:125358640 T/C cg07211511 chr3:129823064 LOC729375 -0.58 -10.64 -0.39 1.84e-24 Blood pressure (smoking interaction); BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg04518342 chr5:131593106 PDLIM4 0.38 9.7 0.36 7.55e-21 Breast cancer; BRCA cis rs7598759 0.548 rs1584462 chr2:232369798 A/G cg19187155 chr2:232395269 NMUR1 0.69 16.53 0.55 2.2e-51 Noise-induced hearing loss; BRCA cis rs1215050 0.704 rs783915 chr4:99023151 C/G cg05340658 chr4:99064831 C4orf37 0.48 10.91 0.4 1.56e-25 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg23285459 chr7:2802560 GNA12 -0.38 -9.55 -0.35 2.77e-20 Height; BRCA cis rs6430585 0.528 rs309119 chr2:136710372 T/C cg07169764 chr2:136633963 MCM6 0.9 17.33 0.57 1.87e-55 Corneal structure; BRCA cis rs172166 0.611 rs203882 chr6:28078502 G/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.38 0.31 3.25e-16 Cardiac Troponin-T levels; BRCA cis rs9318086 0.935 rs9652081 chr13:24435510 C/T cg25267304 chr13:24462978 PCOTH;MIPEP -0.29 -8.4 -0.32 2.99e-16 Myopia (pathological); BRCA cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg04518342 chr5:131593106 PDLIM4 0.45 11.32 0.41 3.22e-27 Acylcarnitine levels; BRCA cis rs35306767 0.855 rs55708963 chr10:925712 C/A cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.58e-21 Eosinophil percentage of granulocytes; BRCA trans rs208520 0.633 rs7738469 chr6:66807446 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.13 -0.64 1.45e-75 Exhaled nitric oxide output; BRCA cis rs9858542 0.537 rs9863142 chr3:49366741 C/G cg00383909 chr3:49044727 WDR6 0.42 9.41 0.35 9.11e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2243480 1.000 rs2177703 chr7:65391717 C/A cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs870825 0.587 rs28454955 chr4:185632701 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA cis rs2730245 0.527 rs2036582 chr7:158701708 A/T cg24397884 chr7:158709396 WDR60 0.89 14.1 0.49 1.68e-39 Height; BRCA cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg05025164 chr4:1340916 KIAA1530 -0.62 -12.78 -0.45 1.73e-33 Longevity; BRCA cis rs4808199 0.948 rs2023883 chr19:19405480 G/A cg03709012 chr19:19516395 GATAD2A 0.96 17.3 0.56 2.93e-55 Nonalcoholic fatty liver disease; BRCA cis rs1707322 1.000 rs4660332 chr1:46461418 T/A cg06784218 chr1:46089804 CCDC17 0.49 11.59 0.42 2.55e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10911232 0.507 rs3935384 chr1:183028970 C/T ch.1.3577855R chr1:183094577 LAMC1 0.62 16.23 0.54 7.45e-50 Hypertriglyceridemia; BRCA cis rs7666738 0.753 rs10033138 chr4:98981922 A/C cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7618915 0.547 rs35211965 chr3:52685305 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 9.61 0.36 1.6e-20 Bipolar disorder; BRCA cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg21926612 chr6:163149169 PACRG;PARK2 1.09 15.62 0.53 8.32e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6750047 0.567 rs336039 chr2:38258827 C/T cg07380506 chr2:38303506 CYP1B1 -0.39 -8.61 -0.32 5.66e-17 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7582180 0.764 rs11693424 chr2:100925439 G/A cg14675211 chr2:100938903 LONRF2 0.49 11.23 0.41 8.09e-27 Intelligence (multi-trait analysis); BRCA cis rs7607369 0.559 rs4674343 chr2:219660346 C/T cg02176678 chr2:219576539 TTLL4 0.4 10.55 0.39 4.26e-24 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs9467711 0.659 rs3823158 chr6:26463271 T/A cg01620082 chr3:125678407 NA -0.69 -8.45 -0.32 1.98e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg08859206 chr1:53392774 SCP2 0.47 10.46 0.38 9.59e-24 Monocyte count; BRCA cis rs60843830 1.000 rs11553746 chr2:272203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.82 18.99 0.6 4.23e-64 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs3857067 0.806 rs2865343 chr4:95103005 C/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.26 -0.34 2.97e-19 QT interval; BRCA cis rs3771570 1.000 rs62190370 chr2:242384194 C/G cg21155796 chr2:242212141 HDLBP 0.61 9.34 0.35 1.6e-19 Prostate cancer; BRCA cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg11833968 chr6:79620685 NA -0.44 -9.8 -0.36 3.14e-21 Intelligence (multi-trait analysis); BRCA cis rs9399137 0.507 rs4289677 chr6:135275485 A/G cg22676075 chr6:135203613 NA 0.45 8.86 0.33 7.85e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1008375 0.932 rs4698630 chr4:17614692 C/G cg15017067 chr4:17643749 FAM184B 0.29 8.98 0.33 3.08e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs425277 1.000 rs421992 chr1:2077260 C/T cg00981070 chr1:2046702 PRKCZ 0.31 8.29 0.31 6.49e-16 Height; BRCA cis rs7098414 0.511 rs7071752 chr10:82159539 C/A cg00277334 chr10:82204260 NA -0.47 -9.94 -0.37 9.2e-22 Post bronchodilator FEV1; BRCA cis rs2836974 0.863 rs12483216 chr21:40539614 T/C cg17971929 chr21:40555470 PSMG1 0.77 18.12 0.58 1.53e-59 Cognitive function; BRCA cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg18404041 chr3:52824283 ITIH1 -0.44 -13.02 -0.46 1.49e-34 Bipolar disorder; BRCA cis rs11229555 0.609 rs7927730 chr11:58187906 G/A cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.13e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.81 0.39 3.95e-25 Bipolar disorder; BRCA cis rs3768617 0.528 rs6672093 chr1:183079853 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.08 0.56 3.74e-54 Fuchs's corneal dystrophy; BRCA cis rs7552404 0.883 rs7513363 chr1:76143443 A/G cg10523679 chr1:76189770 ACADM 0.87 20.48 0.63 4.56e-72 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs910316 0.687 rs11627442 chr14:75669649 A/G cg08847533 chr14:75593920 NEK9 -0.78 -18.04 -0.58 3.88e-59 Height; BRCA cis rs4363385 0.643 rs11576457 chr1:152918556 C/T cg07796016 chr1:152779584 LCE1C 0.45 8.93 0.33 4.59e-18 Inflammatory skin disease; BRCA cis rs875971 0.862 rs11765791 chr7:65936574 A/G cg18876405 chr7:65276391 NA 0.5 11.1 0.4 2.7e-26 Aortic root size; BRCA cis rs11764590 0.694 rs2056477 chr7:2079744 G/C cg23422044 chr7:1970798 MAD1L1 -0.42 -8.24 -0.31 9.93e-16 Neuroticism; BRCA cis rs13191362 0.935 rs67889271 chr6:163045753 T/G cg18825119 chr6:163149453 PACRG;PARK2 0.52 7.99 0.3 6.55e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -8.93 -0.33 4.67e-18 Alzheimer's disease; BRCA cis rs2742417 0.603 rs2064064 chr3:45759995 C/T cg04837898 chr3:45731254 SACM1L -0.4 -8.09 -0.3 3.07e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.73e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.37 0.31 3.56e-16 Axial length; BRCA cis rs311392 1.000 rs413974 chr8:55088510 A/G cg11783602 chr8:55087084 NA -0.32 -9.28 -0.34 2.66e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs9297145 1.000 rs9297145 chr7:98759117 A/C cg05967295 chr7:98741636 SMURF1 0.84 20.08 0.62 6.92e-70 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs4319547 0.656 rs6488951 chr12:122873928 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.34 -0.35 1.53e-19 Body mass index; BRCA cis rs3008870 0.628 rs2755257 chr1:67515309 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.46 9.4 0.35 9.37e-20 Lymphocyte percentage of white cells; BRCA cis rs2985684 1.000 rs1957977 chr14:50090603 A/G cg04989706 chr14:50066350 PPIL5 -0.49 -9.23 -0.34 4.03e-19 Carotid intima media thickness; BRCA cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg26597838 chr10:835615 NA 1.32 22.06 0.66 1.34e-80 Eosinophil percentage of granulocytes; BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg08470875 chr2:26401718 FAM59B -0.72 -11.89 -0.43 1.31e-29 Gut microbiome composition (summer); BRCA cis rs514406 0.825 rs487453 chr1:53271225 T/C cg08859206 chr1:53392774 SCP2 0.49 11.0 0.4 6.95e-26 Monocyte count; BRCA cis rs1468333 1.000 rs34927605 chr5:137580418 T/A cg27119451 chr5:137514611 BRD8;KIF20A 0.44 9.2 0.34 5.2e-19 Resting heart rate; BRCA cis rs7249142 0.549 rs3787040 chr19:19297292 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -10.39 -0.38 1.73e-23 IgG glycosylation; BRCA cis rs243505 0.691 rs243480 chr7:148452905 G/T cg09806900 chr7:148480153 CUL1 -0.44 -7.96 -0.3 7.88e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4722166 0.532 rs4719713 chr7:22758811 G/A cg05472934 chr7:22766657 IL6 0.43 10.71 0.39 9.62e-25 Lung cancer; BRCA cis rs9457247 0.534 rs4710154 chr6:167394634 A/T cg23791538 chr6:167370224 RNASET2 0.5 12.95 0.46 3.21e-34 Crohn's disease; BRCA cis rs7098414 0.511 rs7916349 chr10:82152638 G/A cg01528321 chr10:82214614 TSPAN14 0.67 14.14 0.49 1.03e-39 Post bronchodilator FEV1; BRCA cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg08213375 chr14:104286397 PPP1R13B 0.63 18.11 0.58 1.69e-59 Schizophrenia; BRCA cis rs17270561 0.609 rs9379789 chr6:25745579 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs6878727 0.665 rs161010 chr5:123675617 C/T cg01806427 chr5:123737813 NA -0.37 -8.42 -0.32 2.49e-16 Breast cancer; BRCA cis rs68170813 0.559 rs6946036 chr7:106853659 G/A cg02696742 chr7:106810147 HBP1 -0.52 -8.45 -0.32 1.92e-16 Coronary artery disease; BRCA cis rs79976124 0.879 rs17432710 chr6:66621744 T/C cg07460842 chr6:66804631 NA 0.61 10.35 0.38 2.54e-23 Type 2 diabetes; BRCA cis rs10197940 0.624 rs3771901 chr2:152432481 G/A cg19508488 chr2:152266495 RIF1 0.51 10.39 0.38 1.74e-23 Lung cancer; BRCA cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg24642439 chr20:33292090 TP53INP2 0.53 11.6 0.42 2.23e-28 Glomerular filtration rate (creatinine); BRCA cis rs7385804 0.761 rs576236 chr7:100316975 C/T cg16850897 chr7:100343110 ZAN 0.38 8.48 0.32 1.55e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs11792861 0.926 rs72607166 chr9:111821530 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.19 0.31 1.44e-15 Menarche (age at onset); BRCA cis rs9858542 0.953 rs9814873 chr3:49454112 A/G cg07274523 chr3:49395745 GPX1 0.46 8.11 0.31 2.65e-15 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs3849570 0.925 rs7641973 chr3:81910489 G/A cg07356753 chr3:81810745 GBE1 -0.43 -10.15 -0.37 1.49e-22 Waist circumference;Body mass index; BRCA cis rs12477438 0.501 rs34272114 chr2:99737443 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.15 0.62 2.91e-70 Chronic sinus infection; BRCA cis rs13256369 1.000 rs873064 chr8:8572380 G/A cg00074818 chr8:8560427 CLDN23 0.38 8.38 0.31 3.43e-16 Obesity-related traits; BRCA cis rs6942756 0.915 rs6946938 chr7:129004662 A/C cg02491457 chr7:128862824 NA -0.62 -12.47 -0.44 4.23e-32 White matter hyperintensity burden; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9388451 0.626 rs2875881 chr6:126072853 C/G cg05901451 chr6:126070800 HEY2 -0.56 -14.88 -0.51 3.19e-43 Brugada syndrome; BRCA cis rs2204008 0.774 rs11180977 chr12:38263094 G/T cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA cis rs4073582 0.595 rs9326370 chr11:65992008 A/G cg16950941 chr11:66035639 RAB1B 0.42 11.34 0.41 2.81e-27 Gout; BRCA cis rs919433 0.680 rs788022 chr2:198280586 T/C cg00792783 chr2:198669748 PLCL1 0.38 8.57 0.32 7.95e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2204008 0.617 rs11831608 chr12:38210687 C/T cg26384229 chr12:38710491 ALG10B -0.46 -10.51 -0.38 6.27e-24 Bladder cancer; BRCA cis rs853679 0.517 rs9368551 chr6:28061792 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.22 -0.31 1.17e-15 Depression; BRCA cis rs13053817 1.000 rs12484859 chr22:29844884 A/G cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.51 -9.47 -0.35 5.43e-20 Carotid atherosclerosis in HIV infection; BRCA cis rs78487399 0.908 rs73925553 chr2:43810646 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.85 -0.3 1.82e-14 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs17685 0.753 rs10262501 chr7:75668172 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.41 9.23 0.34 3.9e-19 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7927771 0.965 rs34958982 chr11:47547046 T/C cg18512352 chr11:47633146 NA -0.37 -9.1 -0.34 1.1e-18 Subjective well-being; BRCA cis rs1568889 1.000 rs7949704 chr11:28373543 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 12.95 0.46 3.11e-34 Bipolar disorder; BRCA cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg06221963 chr1:154839813 KCNN3 -0.56 -15.65 -0.53 5.51e-47 Prostate cancer; BRCA trans rs7615952 0.688 rs9754526 chr3:125542866 C/A cg07211511 chr3:129823064 LOC729375 -0.78 -15.1 -0.51 2.81e-44 Blood pressure (smoking interaction); BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg08470875 chr2:26401718 FAM59B -0.51 -8.3 -0.31 6.24e-16 Gut microbiome composition (summer); BRCA cis rs9300255 0.722 rs11830103 chr12:123823546 A/G cg00376283 chr12:123451042 ABCB9 -0.49 -11.16 -0.4 1.49e-26 Neutrophil percentage of white cells; BRCA cis rs72634258 0.554 rs68024107 chr1:7914066 G/C cg26816564 chr1:7831052 VAMP3 0.47 9.5 0.35 4.1e-20 Inflammatory bowel disease; BRCA cis rs3770081 1.000 rs3770066 chr2:86392350 A/T cg23655155 chr2:86332777 POLR1A;PTCD3 -0.56 -7.82 -0.3 2.17e-14 Facial emotion recognition (sad faces); BRCA cis rs7772486 0.686 rs857877 chr6:145976230 A/C cg05347473 chr6:146136440 FBXO30 -0.42 -8.36 -0.31 3.91e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg14844989 chr11:31128820 NA 0.45 9.56 0.35 2.53e-20 Red blood cell count; BRCA cis rs11874712 0.966 rs8094902 chr18:43666774 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.21 0.31 1.24e-15 Migraine - clinic-based; BRCA cis rs6952808 0.564 rs55865401 chr7:2145720 G/C cg02951883 chr7:2050386 MAD1L1 -0.57 -13.96 -0.48 7.58e-39 Bipolar disorder and schizophrenia; BRCA cis rs838147 0.733 rs12978499 chr19:49237552 A/C cg13540341 chr19:49222985 MAMSTR 0.34 9.18 0.34 5.71e-19 Dietary macronutrient intake; BRCA cis rs6543140 0.964 rs1035126 chr2:103019981 C/T cg04239558 chr2:103089729 SLC9A4 0.33 9.14 0.34 8.53e-19 Blood protein levels; BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg13880726 chr7:1868755 MAD1L1 -0.41 -8.5 -0.32 1.36e-16 Bipolar disorder and schizophrenia; BRCA cis rs4148883 0.689 rs1311621 chr4:100014018 T/C cg13256891 chr4:100009986 ADH5 0.39 8.21 0.31 1.25e-15 Alcohol dependence; BRCA cis rs7917772 0.582 rs10786691 chr10:104364652 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.41 0.5 5.57e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10267417 0.603 rs10244374 chr7:19863170 C/T cg05791153 chr7:19748676 TWISTNB 0.48 9.08 0.34 1.33e-18 Night sleep phenotypes; BRCA cis rs8044868 0.530 rs12918956 chr16:72224335 A/G cg16558253 chr16:72132732 DHX38 0.38 9.13 0.34 8.74e-19 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs7394190 0.810 rs7394152 chr10:75421446 C/T cg07699608 chr10:75541558 CHCHD1 0.55 8.73 0.33 2.3e-17 Incident atrial fibrillation; BRCA cis rs243505 0.668 rs2072406 chr7:148483760 G/A cg09806900 chr7:148480153 CUL1 0.52 10.94 0.4 1.16e-25 Inflammatory bowel disease;Crohn's disease; BRCA cis rs68170813 0.559 rs2395881 chr7:107074323 A/C cg02696742 chr7:106810147 HBP1 -0.51 -7.98 -0.3 6.78e-15 Coronary artery disease; BRCA cis rs60843830 1.000 rs79716074 chr2:277003 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.41 0.5 5.73e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4853012 0.775 rs12465641 chr2:74337715 A/G cg01017244 chr2:74357527 NA -0.49 -10.54 -0.38 4.57e-24 Gestational age at birth (maternal effect); BRCA cis rs1153858 1.000 rs4395020 chr15:45652889 A/C cg21132104 chr15:45694354 SPATA5L1 0.73 16.58 0.55 1.26e-51 Homoarginine levels; BRCA cis rs72634258 0.945 rs28624 chr1:8084355 G/T cg00042356 chr1:8021962 PARK7 -0.49 -8.55 -0.32 8.92e-17 Inflammatory bowel disease; BRCA cis rs2235642 0.787 rs2235646 chr16:1601287 A/G cg26528668 chr16:1614120 IFT140 0.39 8.99 0.34 2.8e-18 Coronary artery disease; BRCA cis rs4919694 1.000 rs12246689 chr10:104817031 C/T cg04362960 chr10:104952993 NT5C2 0.95 14.59 0.5 7.86e-42 Arsenic metabolism; BRCA cis rs7647973 0.554 rs13096480 chr3:49658084 A/G cg03060546 chr3:49711283 APEH 0.6 10.21 0.37 8.9e-23 Menarche (age at onset); BRCA cis rs1707322 1.000 rs10789486 chr1:46408667 A/G cg03146154 chr1:46216737 IPP 0.47 10.5 0.38 6.48e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs6089829 0.962 rs3899032 chr20:61658542 G/A cg23505145 chr19:12996616 KLF1 0.56 12.63 0.45 8.41e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs208520 0.661 rs7740835 chr6:66865548 G/A cg07460842 chr6:66804631 NA -1.0 -19.6 -0.61 2.44e-67 Exhaled nitric oxide output; BRCA cis rs6545883 0.783 rs12713442 chr2:61848078 G/A cg15711740 chr2:61764176 XPO1 -0.47 -11.67 -0.42 1.11e-28 Tuberculosis; BRCA cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg11833968 chr6:79620685 NA -0.4 -8.9 -0.33 5.7e-18 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.517 rs75486476 chr8:58056079 G/T cg21724239 chr8:58056113 NA 0.77 19.13 0.6 7.97e-65 Developmental language disorder (linguistic errors); BRCA cis rs4588572 0.643 rs10942857 chr5:77760241 A/G cg11547950 chr5:77652471 NA -0.48 -8.41 -0.32 2.77e-16 Triglycerides; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 19.62 0.61 1.82e-67 Platelet count; BRCA cis rs9807989 0.507 rs10200952 chr2:103027651 A/C cg03938978 chr2:103052716 IL18RAP 0.29 8.33 0.31 4.81e-16 Asthma; BRCA cis rs2251381 0.778 rs722013 chr21:30549245 G/T cg08807101 chr21:30365312 RNF160 0.57 12.31 0.44 2.09e-31 Selective IgA deficiency; BRCA cis rs921968 0.541 rs2241527 chr2:219537224 A/G cg10223061 chr2:219282414 VIL1 -0.29 -8.13 -0.31 2.28e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs868036 1.000 rs6494696 chr15:68103206 C/G cg24579218 chr15:68104479 NA 0.3 7.81 0.3 2.38e-14 Restless legs syndrome; BRCA cis rs2882667 0.858 rs66839813 chr5:138442322 A/T cg04439458 chr5:138467593 SIL1 -0.42 -10.66 -0.39 1.54e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7662987 0.517 rs1154410 chr4:100006645 A/G cg13256891 chr4:100009986 ADH5 0.54 10.18 0.37 1.21e-22 Smoking initiation; BRCA trans rs4650994 0.544 rs2811311 chr1:178617337 A/G cg05059571 chr16:84539110 KIAA1609 0.56 12.23 0.44 4.61e-31 HDL cholesterol levels;HDL cholesterol; BRCA cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.64e-18 Developmental language disorder (linguistic errors); BRCA cis rs4845875 0.600 rs4846039 chr1:11836868 A/G cg24844545 chr1:11908347 NPPA 0.37 8.68 0.32 3.35e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6598955 0.671 rs41285347 chr1:26644399 C/T cg04990556 chr1:26633338 UBXN11 0.54 8.87 0.33 7.24e-18 Obesity-related traits; BRCA cis rs698833 0.741 rs2340808 chr2:44511861 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.54 10.58 0.39 3.12e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs1577917 1.000 rs35419329 chr6:86702291 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -7.83 -0.3 1.98e-14 Response to antipsychotic treatment; BRCA cis rs425277 0.538 rs169037 chr1:2095582 G/T cg04315214 chr1:2043799 PRKCZ -0.48 -13.34 -0.47 5.28e-36 Height; BRCA cis rs72781680 0.800 rs6718635 chr2:24066183 A/C cg08917208 chr2:24149416 ATAD2B 1.1 15.5 0.52 3.23e-46 Lymphocyte counts; BRCA cis rs367943 0.965 rs463249 chr5:112797430 A/C cg12552261 chr5:112820674 MCC -0.55 -12.0 -0.43 4.74e-30 Type 2 diabetes; BRCA cis rs7607369 0.536 rs4674345 chr2:219671598 A/G cg02176678 chr2:219576539 TTLL4 -0.36 -9.58 -0.35 2.09e-20 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs501916 0.833 rs3809486 chr15:48051549 G/T cg16110827 chr15:48056943 SEMA6D -0.43 -9.29 -0.34 2.42e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg06766960 chr11:133703094 NA -0.62 -12.86 -0.45 7.96e-34 Childhood ear infection; BRCA trans rs3749237 0.964 rs2352967 chr3:49871641 C/T cg21659725 chr3:3221576 CRBN 0.51 12.14 0.43 1.16e-30 Resting heart rate; BRCA cis rs10504229 1.000 rs17217033 chr8:58180061 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs2243480 1.000 rs313809 chr7:65499983 G/A cg18252515 chr7:66147081 NA -0.91 -13.01 -0.46 1.66e-34 Diabetic kidney disease; BRCA cis rs5167 0.504 rs10426750 chr19:45457684 G/C cg13119609 chr19:45449297 APOC2 0.47 12.92 0.46 4.46e-34 Blood protein levels; BRCA cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg16339924 chr4:17578868 LAP3 0.62 15.3 0.52 3.13e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4690686 0.500 rs11725547 chr4:177268444 T/C cg17059388 chr4:177262070 NA 0.53 11.05 0.4 4.09e-26 Essential tremor; BRCA cis rs733592 0.524 rs10875744 chr12:48498440 G/C cg24011408 chr12:48396354 COL2A1 0.43 9.57 0.35 2.23e-20 Plateletcrit; BRCA cis rs853679 0.546 rs483143 chr6:27846744 G/C cg26587870 chr6:27730563 NA -0.53 -8.11 -0.31 2.53e-15 Depression; BRCA cis rs4566357 0.615 rs2272204 chr2:227915601 G/T cg05526886 chr2:227700861 RHBDD1 -0.39 -8.22 -0.31 1.13e-15 Coronary artery disease; BRCA cis rs9318086 0.901 rs7336730 chr13:24452104 T/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.28 -8.05 -0.3 4.04e-15 Myopia (pathological); BRCA cis rs4363385 0.720 rs6672735 chr1:152981086 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.33 -0.31 4.81e-16 Inflammatory skin disease; BRCA cis rs4363385 0.818 rs11205167 chr1:152989727 T/G cg24667326 chr1:152973720 SPRR3 -0.31 -8.24 -0.31 1.01e-15 Inflammatory skin disease; BRCA cis rs4268898 0.662 rs2891382 chr2:24511491 C/G cg06627628 chr2:24431161 ITSN2 -0.73 -13.77 -0.48 5.8e-38 Asthma; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg00106254 chr7:1943704 MAD1L1 0.4 10.88 0.4 1.98e-25 Bipolar disorder and schizophrenia; BRCA cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs6430585 0.583 rs1435577 chr2:136624947 C/G cg07169764 chr2:136633963 MCM6 1.28 28.6 0.75 1.86e-116 Corneal structure; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.48 -8.76 -0.33 1.69e-17 Gut microbiome composition (summer); BRCA cis rs6545883 0.826 rs1186697 chr2:61661417 G/A cg15711740 chr2:61764176 XPO1 -0.51 -12.37 -0.44 1.12e-31 Tuberculosis; BRCA cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg15556689 chr8:8085844 FLJ10661 -0.41 -11.75 -0.42 5.56e-29 Mood instability; BRCA cis rs4561483 0.801 rs154148 chr16:11956478 T/C cg08843971 chr16:11963173 GSPT1 -0.52 -11.7 -0.42 8.84e-29 Testicular germ cell tumor; BRCA cis rs7666738 0.830 rs17486413 chr4:99060544 G/T cg05340658 chr4:99064831 C4orf37 0.66 15.65 0.53 5.39e-47 Colonoscopy-negative controls vs population controls; BRCA cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg08917208 chr2:24149416 ATAD2B 0.55 8.52 0.32 1.12e-16 Lymphocyte counts; BRCA cis rs13256369 0.950 rs12548792 chr8:8568031 T/C cg00074818 chr8:8560427 CLDN23 0.4 8.66 0.32 3.79e-17 Obesity-related traits; BRCA cis rs2882667 0.690 rs6872423 chr5:138246778 T/C cg04439458 chr5:138467593 SIL1 -0.31 -7.95 -0.3 8.32e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2555155 1.000 rs11040899 chr11:6520015 A/C cg18103150 chr11:6518907 DNHD1 0.36 8.31 0.31 5.81e-16 DNA methylation (variation); BRCA cis rs2576037 0.583 rs2164104 chr18:44567743 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.56 11.44 0.41 1.05e-27 Personality dimensions; BRCA cis rs77956314 0.515 rs4767490 chr12:117435016 A/G cg06698575 chr12:117470875 NA 0.45 8.06 0.3 3.76e-15 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs3858526 0.883 rs11039686 chr11:5948725 T/C cg13902645 chr11:5959945 NA -0.54 -11.14 -0.4 1.88e-26 DNA methylation (variation); BRCA cis rs2032447 0.507 rs199748 chr6:25909045 C/G cg03517284 chr6:25882590 NA -0.7 -15.05 -0.51 4.78e-44 Intelligence (multi-trait analysis); BRCA trans rs7829975 0.533 rs1039917 chr8:8718850 C/T cg16141378 chr3:129829833 LOC729375 -0.34 -7.93 -0.3 9.65e-15 Mood instability; BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.19 -0.31 1.43e-15 Total body bone mineral density; BRCA cis rs765787 0.530 rs12915027 chr15:45512626 G/A cg25801113 chr15:45476975 SHF -0.33 -8.26 -0.31 8.52e-16 Uric acid levels; BRCA cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg24562669 chr7:97807699 LMTK2 0.45 12.01 0.43 4.07e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7267979 1.000 rs4815409 chr20:25346697 C/A cg08601574 chr20:25228251 PYGB -0.34 -8.12 -0.31 2.42e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1008375 0.900 rs1003413 chr4:17582442 C/T cg16339924 chr4:17578868 LAP3 -0.74 -17.85 -0.58 3.89e-58 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs78761021 0.867 rs8077037 chr17:9788746 G/A cg26853458 chr17:9805074 RCVRN 0.36 8.28 0.31 7.34e-16 Type 2 diabetes; BRCA cis rs1691799 0.867 rs1168343 chr12:66758581 C/T cg16791601 chr12:66731901 HELB -0.66 -18.04 -0.58 4.35e-59 White blood cell count (basophil); BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg19626725 chr5:178986131 RUFY1 0.28 8.09 0.3 3.03e-15 Lung cancer; BRCA cis rs1008375 1.000 rs2215450 chr4:17675394 T/G cg04450456 chr4:17643702 FAM184B 0.39 11.78 0.42 3.83e-29 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg23708337 chr7:1209742 NA 0.59 12.86 0.45 8.32e-34 Longevity;Endometriosis; BRCA cis rs701145 0.585 rs357480 chr3:153891182 A/G cg17054900 chr3:154042577 DHX36 0.56 9.48 0.35 4.82e-20 Coronary artery disease; BRCA cis rs9399137 0.507 rs4520025 chr6:135278619 G/T cg22676075 chr6:135203613 NA 0.4 8.18 0.31 1.51e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg00750074 chr16:89608354 SPG7 0.29 7.86 0.3 1.68e-14 Multiple myeloma (IgH translocation); BRCA cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg11644478 chr21:40555479 PSMG1 0.67 15.19 0.52 1.01e-44 Cognitive function; BRCA cis rs10992471 0.528 rs6479423 chr9:95265580 A/T cg14631576 chr9:95140430 CENPP -0.33 -8.4 -0.32 2.98e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg07636037 chr3:49044803 WDR6 0.88 23.11 0.67 2.25e-86 Parkinson's disease; BRCA cis rs28374715 0.681 rs77187862 chr15:41619276 A/T cg18705301 chr15:41695430 NDUFAF1 -0.81 -17.94 -0.58 1.43e-58 Ulcerative colitis; BRCA cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg04414720 chr1:150670196 GOLPH3L 0.35 7.9 0.3 1.22e-14 Tonsillectomy; BRCA cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg15017067 chr4:17643749 FAM184B 0.34 10.48 0.38 8.32e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 0.505 rs1167385 chr7:65513308 G/A cg11764359 chr7:65958608 NA -0.65 -14.23 -0.49 3.95e-40 Aortic root size; BRCA cis rs17270561 0.609 rs9358886 chr6:25758253 T/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.64 0.32 4.64e-17 Iron status biomarkers; BRCA cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg13175981 chr1:150552382 MCL1 0.35 7.92 0.3 1.02e-14 Urate levels; BRCA cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg18479299 chr3:125709523 NA -0.54 -8.46 -0.32 1.82e-16 Blood pressure (smoking interaction); BRCA cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg24549020 chr5:56110836 MAP3K1 -0.59 -12.0 -0.43 4.83e-30 Initial pursuit acceleration; BRCA trans rs1493916 0.655 rs4534926 chr18:31349072 G/C cg15819921 chr19:927150 ARID3A -0.53 -9.75 -0.36 4.78e-21 Life satisfaction; BRCA cis rs736801 0.808 rs2522057 chr5:131801947 C/G cg07395648 chr5:131743802 NA -0.37 -8.7 -0.33 2.86e-17 Breast cancer;Mosquito bite size; BRCA cis rs2425143 0.908 rs6060632 chr20:34422601 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.21 -0.31 1.27e-15 Blood protein levels; BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.79 -0.42 3.63e-29 Gut microbiome composition (summer); BRCA cis rs2832191 0.646 rs2832210 chr21:30508723 T/G cg08807101 chr21:30365312 RNF160 -0.44 -9.4 -0.35 9.88e-20 Dental caries; BRCA cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06022373 chr22:39101656 GTPBP1 0.74 18.2 0.58 5.93e-60 Menopause (age at onset); BRCA cis rs1843834 0.734 rs1908251 chr2:225487865 T/C cg22455342 chr2:225449267 CUL3 0.37 9.12 0.34 9.84e-19 IgE levels in asthmatics (D.p. specific); BRCA cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.89 -0.33 6.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs600806 0.888 rs4603158 chr1:109879549 C/T cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.5e-15 Intelligence (multi-trait analysis); BRCA cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg16950941 chr11:66035639 RAB1B 0.45 12.09 0.43 1.95e-30 Gout; BRCA cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg16414030 chr3:133502952 NA -0.49 -11.41 -0.41 1.43e-27 Iron status biomarkers; BRCA trans rs11098499 0.954 rs11935596 chr4:120412457 G/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.89 -0.3 1.27e-14 Corneal astigmatism; BRCA cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.59e-18 Developmental language disorder (linguistic errors); BRCA cis rs367943 1.000 rs348958 chr5:112821137 G/A cg12552261 chr5:112820674 MCC -0.55 -12.1 -0.43 1.66e-30 Type 2 diabetes; BRCA cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg04775059 chr7:64541387 NA 0.46 8.49 0.32 1.49e-16 Calcium levels; BRCA cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg12270520 chr8:146023939 ZNF517 -0.4 -9.18 -0.34 5.85e-19 Age at first birth; BRCA cis rs35110281 0.782 rs2838329 chr21:45023329 T/C cg01579765 chr21:45077557 HSF2BP -0.42 -11.35 -0.41 2.4e-27 Mean corpuscular volume; BRCA cis rs6912958 0.781 rs9450723 chr6:88226641 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.43 8.59 0.32 6.57e-17 Monocyte percentage of white cells; BRCA cis rs13191362 0.938 rs13192618 chr6:163132822 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.54 0.38 4.46e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6582630 0.502 rs11181475 chr12:38348922 G/A cg13010199 chr12:38710504 ALG10B 0.45 9.38 0.35 1.16e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs11190604 1.000 rs6584383 chr10:102303065 C/G cg07080220 chr10:102295463 HIF1AN 0.56 13.04 0.46 1.19e-34 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4319547 0.876 rs10846978 chr12:122964708 T/C cg05707623 chr12:122985044 ZCCHC8 -0.5 -10.11 -0.37 2.21e-22 Body mass index; BRCA cis rs7777484 0.571 rs2527686 chr7:2834413 G/A cg19717773 chr7:2847554 GNA12 -0.48 -11.28 -0.41 5.09e-27 Height; BRCA cis rs6931421 0.800 rs12662365 chr6:80905389 T/A cg08355045 chr6:80787529 NA 0.44 9.61 0.36 1.62e-20 Sitting height ratio; BRCA cis rs4285028 0.898 rs73855476 chr3:121633412 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.64 -11.59 -0.42 2.52e-28 Multiple sclerosis; BRCA cis rs495337 0.760 rs2769975 chr20:48516511 A/C cg17835207 chr20:48524531 SPATA2 -0.68 -16.29 -0.54 3.78e-50 Psoriasis; BRCA cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.39 -0.32 3.11e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs9291683 0.588 rs2240721 chr4:10020564 G/A cg02734326 chr4:10020555 SLC2A9 0.41 8.93 0.33 4.44e-18 Bone mineral density; BRCA cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg18964960 chr10:1102726 WDR37 0.63 8.71 0.33 2.65e-17 Eosinophil percentage of granulocytes; BRCA cis rs6120849 0.901 rs6060266 chr20:33733078 T/C cg24642439 chr20:33292090 TP53INP2 0.48 8.38 0.31 3.42e-16 Protein C levels; BRCA cis rs875971 0.964 rs60193905 chr7:65971260 A/G cg11764359 chr7:65958608 NA 0.79 19.08 0.6 1.37e-64 Aortic root size; BRCA cis rs12188164 0.620 rs1043356 chr5:480948 C/T cg15640734 chr5:494837 SLC9A3 0.4 7.96 0.3 8.11e-15 Cystic fibrosis severity; BRCA cis rs1215050 0.740 rs1084784 chr4:98961711 T/G cg05340658 chr4:99064831 C4orf37 -0.47 -10.94 -0.4 1.23e-25 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1468333 0.964 rs2350306 chr5:137512178 G/A cg27119451 chr5:137514611 BRD8;KIF20A -0.43 -9.05 -0.34 1.7e-18 Resting heart rate; BRCA cis rs921968 0.541 rs532425 chr2:219434194 A/G cg02176678 chr2:219576539 TTLL4 0.46 12.16 0.43 9.47e-31 Mean corpuscular hemoglobin concentration; BRCA trans rs2262909 0.962 rs11673195 chr19:22313814 T/C cg17074339 chr11:11642133 GALNTL4 0.45 8.83 0.33 1.01e-17 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg00684032 chr4:1343700 KIAA1530 0.31 7.93 0.3 1.01e-14 Obesity-related traits; BRCA cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg09877947 chr5:131593287 PDLIM4 0.34 8.43 0.32 2.3e-16 Blood metabolite levels; BRCA cis rs897984 0.542 rs3751855 chr16:31091209 T/C cg00531865 chr16:30841666 NA -0.38 -9.09 -0.34 1.21e-18 Dementia with Lewy bodies; BRCA cis rs9814567 0.896 rs7653880 chr3:134345788 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.36 -8.38 -0.31 3.41e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2882667 0.931 rs6596457 chr5:138323379 T/C cg04439458 chr5:138467593 SIL1 -0.34 -9.17 -0.34 6.56e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg13047869 chr3:10149882 C3orf24 0.6 12.62 0.45 9.38e-33 Alzheimer's disease; BRCA trans rs3749237 0.964 rs7431078 chr3:49808190 G/A cg21659725 chr3:3221576 CRBN 0.5 11.85 0.42 2.08e-29 Resting heart rate; BRCA cis rs2742540 0.503 rs7106539 chr11:8897533 T/G cg12365402 chr11:9010492 NRIP3 -0.37 -8.35 -0.31 4.17e-16 Hematocrit; BRCA cis rs10899021 0.920 rs7112664 chr11:74348426 T/C cg25880958 chr11:74394337 NA -0.49 -7.88 -0.3 1.43e-14 Response to metformin (IC50); BRCA cis rs1348850 0.574 rs13431105 chr2:178434674 A/G cg27490568 chr2:178487706 NA 0.56 8.91 0.33 5.34e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs7659604 0.605 rs1507994 chr4:122749541 C/T cg20573242 chr4:122745356 CCNA2 0.5 12.83 0.45 1.05e-33 Type 2 diabetes; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg20219911 chr3:52813652 ITIH1 0.3 8.21 0.31 1.18e-15 Bipolar disorder; BRCA cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.98e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs17228212 0.555 rs7179840 chr15:67458930 A/G cg26876701 chr15:67458665 SMAD3 -0.37 -8.63 -0.32 4.71e-17 Coronary heart disease; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg27094323 chr7:1216898 NA -0.35 -8.09 -0.3 3.08e-15 Longevity;Endometriosis; BRCA cis rs12200560 0.505 rs211175 chr6:97073320 C/T cg06623918 chr6:96969491 KIAA0776 0.52 12.48 0.44 3.91e-32 Coronary heart disease; BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs4148883 0.645 rs2851287 chr4:100014548 G/A cg13256891 chr4:100009986 ADH5 0.38 8.06 0.3 3.66e-15 Alcohol dependence; BRCA cis rs727479 0.543 rs1065778 chr15:51520206 T/C cg19946085 chr15:51559439 CYP19A1 -0.29 -7.97 -0.3 7.44e-15 Estradiol levels; BRCA trans rs7980799 0.935 rs10772076 chr12:33553574 A/C cg26384229 chr12:38710491 ALG10B -0.39 -8.18 -0.31 1.51e-15 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.64 -14.25 -0.49 3.37e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1707322 0.686 rs3014235 chr1:46091512 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -12.72 -0.45 3.23e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.683 rs11775568 chr8:58133762 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -8.15 -0.31 1.98e-15 Developmental language disorder (linguistic errors); BRCA cis rs9733 0.744 rs12126004 chr1:150889877 T/C cg18016565 chr1:150552671 MCL1 -0.36 -8.24 -0.31 9.94e-16 Tonsillectomy; BRCA trans rs3942852 0.696 rs4597030 chr11:48176573 G/A cg03929089 chr4:120376271 NA -0.5 -9.47 -0.35 5.34e-20 Acute lymphoblastic leukemia (childhood); BRCA trans rs11098499 0.774 rs73842616 chr4:120290683 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.16 0.4 1.48e-26 Bipolar disorder; BRCA cis rs2204008 0.715 rs11514282 chr12:38169056 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs12497850 0.931 rs6446196 chr3:49004723 A/G cg07636037 chr3:49044803 WDR6 0.97 28.46 0.75 1.02e-115 Parkinson's disease; BRCA cis rs4319547 0.915 rs7966094 chr12:123115771 A/G cg23029597 chr12:123009494 RSRC2 -0.61 -12.25 -0.44 4.02e-31 Body mass index; BRCA cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg13319975 chr6:146136371 FBXO30 -0.38 -8.37 -0.31 3.51e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg08000102 chr2:233561755 GIGYF2 0.64 13.98 0.48 6e-39 Coronary artery disease; BRCA trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg17470723 chr8:74884337 TCEB1 0.4 8.72 0.33 2.46e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs617791 0.669 rs4994056 chr11:65750997 G/A cg17712092 chr4:129076599 LARP1B 0.54 13.08 0.46 8.53e-35 Breast cancer; BRCA cis rs1008375 0.966 rs2315645 chr4:17579678 G/C cg04450456 chr4:17643702 FAM184B 0.41 12.47 0.44 4.04e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs3733585 0.673 rs7672947 chr4:9961368 G/C cg26043149 chr18:55253948 FECH -0.38 -8.23 -0.31 1.03e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg22963979 chr7:1858916 MAD1L1 -0.42 -8.82 -0.33 1.04e-17 Bipolar disorder and schizophrenia; BRCA cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg11764359 chr7:65958608 NA 0.46 9.06 0.34 1.51e-18 Calcium levels; BRCA cis rs7552404 1.000 rs2133134 chr1:76179587 G/A cg10523679 chr1:76189770 ACADM 0.75 15.61 0.53 8.73e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.77 -0.42 4.42e-29 Alcohol dependence; BRCA cis rs2239547 0.521 rs9682464 chr3:52888485 C/T cg18404041 chr3:52824283 ITIH1 -0.35 -9.09 -0.34 1.23e-18 Schizophrenia; BRCA cis rs17270561 0.609 rs9379789 chr6:25745579 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs12477438 1.000 rs6542873 chr2:99824965 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -13.97 -0.48 7.03e-39 Chronic sinus infection; BRCA cis rs7918232 0.627 rs6482588 chr10:27308307 G/C cg14240646 chr10:27532245 ACBD5 -0.58 -9.72 -0.36 6.21e-21 Breast cancer; BRCA cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg16339924 chr4:17578868 LAP3 0.66 16.62 0.55 8.01e-52 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9929218 1.000 rs9936621 chr16:68798682 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.92 -0.48 1.18e-38 Colorectal cancer; BRCA cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg02297831 chr4:17616191 MED28 0.38 8.85 0.33 8.39e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9393692 1.000 rs3999544 chr6:26285867 C/T cg05868516 chr6:26286170 HIST1H4H 0.46 9.25 0.34 3.4e-19 Educational attainment; BRCA trans rs7824557 0.767 rs3808513 chr8:11157460 G/T cg06636001 chr8:8085503 FLJ10661 -0.55 -10.66 -0.39 1.61e-24 Retinal vascular caliber; BRCA cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.52 8.51 0.32 1.21e-16 Renal function-related traits (BUN); BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.31 -0.31 5.66e-16 Total body bone mineral density; BRCA cis rs7103648 0.735 rs3824869 chr11:47378245 T/C cg20307385 chr11:47447363 PSMC3 -0.8 -19.71 -0.61 6.16e-68 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs3768617 0.510 rs10797835 chr1:183072908 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.34e-58 Fuchs's corneal dystrophy; BRCA cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.22e-18 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.632 rs12115301 chr9:5180548 A/G cg02405213 chr9:5042618 JAK2 0.46 8.74 0.33 2.11e-17 Pediatric autoimmune diseases; BRCA cis rs6740322 0.895 rs6760797 chr2:43559612 G/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -11.65 -0.42 1.46e-28 Coronary artery disease; BRCA cis rs2576037 0.526 rs626217 chr18:44429182 T/G cg19077165 chr18:44547161 KATNAL2 -0.53 -11.51 -0.41 5.23e-28 Personality dimensions; BRCA cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg00750074 chr16:89608354 SPG7 -0.41 -11.11 -0.4 2.43e-26 Multiple myeloma (IgH translocation); BRCA cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.4 0.49 6.57e-41 Motion sickness; BRCA cis rs2066819 1.000 rs17118439 chr12:56667604 C/T cg26734620 chr12:56694298 CS -0.86 -10.24 -0.38 7.13e-23 Psoriasis vulgaris; BRCA trans rs1459104 1.000 rs35597725 chr11:55311828 T/G cg15704280 chr7:45808275 SEPT13 0.64 8.07 0.3 3.57e-15 Body mass index; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg22963979 chr7:1858916 MAD1L1 -0.45 -9.18 -0.34 5.77e-19 Bipolar disorder and schizophrenia; BRCA cis rs9986765 1.000 rs10243198 chr7:142822210 C/T cg22531018 chr7:142981779 TMEM139 0.6 10.29 0.38 4.37e-23 Cancer;Dermatomyositis; BRCA cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg17691542 chr6:26056736 HIST1H1C 0.48 9.82 0.36 2.8e-21 Height; BRCA cis rs17711722 0.565 rs73372653 chr7:65442795 A/T cg18876405 chr7:65276391 NA 0.53 11.72 0.42 7.42e-29 Calcium levels; BRCA cis rs6586163 0.527 rs3824730 chr10:90752128 A/T cg03111039 chr10:90751583 FAS;ACTA2 0.57 13.14 0.46 4.22e-35 Chronic lymphocytic leukemia; BRCA cis rs8180040 0.522 rs749512 chr3:47035900 C/T cg16586182 chr3:47516702 SCAP 0.52 11.28 0.41 4.82e-27 Colorectal cancer; BRCA cis rs45509595 0.841 rs9368531 chr6:27781872 G/C cg26587870 chr6:27730563 NA -0.52 -8.02 -0.3 5.04e-15 Breast cancer; BRCA cis rs7829975 0.714 rs11784052 chr8:8671962 C/T cg15556689 chr8:8085844 FLJ10661 0.4 11.43 0.41 1.15e-27 Mood instability; BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg17158414 chr2:27665306 KRTCAP3 -0.36 -8.99 -0.33 2.83e-18 Total body bone mineral density; BRCA cis rs4363385 0.720 rs1338178 chr1:152981550 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.79e-16 Inflammatory skin disease; BRCA cis rs6860806 0.632 rs4330455 chr5:131586349 T/C cg09877947 chr5:131593287 PDLIM4 0.4 10.05 0.37 3.83e-22 Breast cancer; BRCA cis rs6460942 0.915 rs17541464 chr7:12462675 A/G cg20607287 chr7:12443886 VWDE -0.52 -8.19 -0.31 1.45e-15 Coronary artery disease; BRCA cis rs4566357 0.615 rs4350744 chr2:227918146 A/T cg11843606 chr2:227700838 RHBDD1 -0.43 -9.56 -0.35 2.41e-20 Coronary artery disease; BRCA cis rs61990749 0.597 rs2032781 chr14:78214875 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.82 0.36 2.75e-21 Fibroblast growth factor basic levels; BRCA cis rs3820928 0.874 rs7562776 chr2:227806550 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.88 -0.33 6.91e-18 Pulmonary function; BRCA cis rs6570726 0.791 rs407887 chr6:145843759 C/T cg05347473 chr6:146136440 FBXO30 0.4 7.86 0.3 1.65e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs832540 0.695 rs702686 chr5:56201350 A/G cg20203395 chr5:56204925 C5orf35 -0.37 -8.42 -0.32 2.4e-16 Coronary artery disease; BRCA cis rs7662987 0.517 rs2602876 chr4:100039535 A/T cg12011299 chr4:100065546 ADH4 0.48 11.37 0.41 2.04e-27 Smoking initiation; BRCA cis rs1499972 0.941 rs62264762 chr3:117634443 C/A cg07612923 chr3:117604196 NA 0.6 8.12 0.31 2.32e-15 Schizophrenia; BRCA cis rs2404602 0.622 rs11632670 chr15:76974055 A/G cg23625390 chr15:77176239 SCAPER -0.54 -13.99 -0.48 5.47e-39 Blood metabolite levels; BRCA cis rs7264396 0.709 rs2425073 chr20:34293699 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -16.11 -0.54 3.06e-49 Total cholesterol levels; BRCA cis rs708547 1.000 rs10003229 chr4:57809598 A/C cg25525207 chr4:57843836 C4orf14;POLR2B 0.5 8.54 0.32 9.51e-17 Response to bleomycin (chromatid breaks); BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg14863265 chr7:2801509 GNA12 -0.48 -10.16 -0.37 1.43e-22 Height; BRCA trans rs2797160 1.000 rs61299898 chr6:126007651 G/C cg05039488 chr6:79577232 IRAK1BP1 0.35 7.92 0.3 1.05e-14 Endometrial cancer; BRCA trans rs11098499 0.615 rs59867181 chr4:120556467 C/T cg25214090 chr10:38739885 LOC399744 -0.4 -9.25 -0.34 3.38e-19 Corneal astigmatism; BRCA cis rs2645694 0.626 rs2703124 chr4:77820626 G/T cg03477792 chr4:77819574 ANKRD56 0.66 15.67 0.53 4.35e-47 Emphysema distribution in smoking; BRCA cis rs965469 1.000 rs6037554 chr20:3315613 G/A cg25506879 chr20:3388711 C20orf194 -0.53 -10.56 -0.39 3.9e-24 IFN-related cytopenia; BRCA trans rs2204008 0.548 rs2320740 chr12:38166421 G/A cg06521331 chr12:34319734 NA -0.5 -9.31 -0.35 1.97e-19 Bladder cancer; BRCA cis rs7666738 0.791 rs7658177 chr4:99035192 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6740322 0.748 rs6544635 chr2:43486704 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.72 -13.11 -0.46 5.86e-35 Coronary artery disease; BRCA cis rs1712517 1.000 rs1712517 chr10:105033015 C/T cg05636881 chr10:105038444 INA 0.35 8.18 0.31 1.49e-15 Migraine; BRCA cis rs765787 0.530 rs7167731 chr15:45510900 T/C cg24006582 chr15:45444508 DUOX1 0.56 11.14 0.4 1.85e-26 Uric acid levels; BRCA cis rs17376456 0.877 rs13170509 chr5:93378564 T/C cg25358565 chr5:93447407 FAM172A 1.23 18.35 0.59 1.04e-60 Diabetic retinopathy; BRCA cis rs1577917 0.958 rs2197648 chr6:86543887 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.43 -0.41 1.14e-27 Response to antipsychotic treatment; BRCA cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg12310025 chr6:25882481 NA -0.43 -10.01 -0.37 5.23e-22 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.954 rs114134184 chr8:58181969 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs4319547 0.656 rs10846664 chr12:122823777 C/T cg05707623 chr12:122985044 ZCCHC8 0.47 9.36 0.35 1.33e-19 Body mass index; BRCA cis rs921968 0.565 rs2037622 chr2:219609440 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -10.98 -0.4 8.53e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs6120849 0.707 rs6120826 chr20:33671831 G/A cg24642439 chr20:33292090 TP53INP2 0.59 10.18 0.37 1.16e-22 Protein C levels; BRCA cis rs875971 0.767 rs61348003 chr7:66005934 C/T cg18876405 chr7:65276391 NA 0.5 11.04 0.4 4.74e-26 Aortic root size; BRCA cis rs11083475 0.681 rs62121377 chr19:39257296 G/A cg07905965 chr19:39260460 NA 0.49 11.42 0.41 1.34e-27 Heart rate; BRCA trans rs1478897 0.804 rs9329246 chr8:11392880 A/G cg15556689 chr8:8085844 FLJ10661 0.35 9.06 0.34 1.6e-18 Systemic lupus erythematosus; BRCA cis rs561341 1.000 rs484175 chr17:30309041 G/A cg23018236 chr17:30244563 NA -0.61 -10.05 -0.37 3.63e-22 Hip circumference adjusted for BMI; BRCA trans rs9858542 1.000 rs9836291 chr3:49697459 G/A cg21659725 chr3:3221576 CRBN -0.46 -9.84 -0.36 2.3e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs600806 0.778 rs10857787 chr1:110010289 C/T cg20591472 chr1:110008990 SYPL2 0.31 7.89 0.3 1.33e-14 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs61212428 chr8:58173963 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs7147624 1.000 rs10135969 chr14:65982345 C/T cg03016385 chr14:66212404 NA -0.58 -8.63 -0.32 4.99e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs10463316 0.832 rs246482 chr5:150731857 C/G cg03212797 chr5:150827313 SLC36A1 -0.45 -8.58 -0.32 7.3e-17 Metabolite levels (Pyroglutamine); BRCA cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg05347473 chr6:146136440 FBXO30 0.39 7.81 0.3 2.32e-14 Lobe attachment (rater-scored or self-reported); BRCA trans rs637571 0.726 rs526631 chr11:65681965 T/G cg17712092 chr4:129076599 LARP1B -0.68 -17.32 -0.57 2.3e-55 Eosinophil percentage of white cells; BRCA cis rs12997796 0.556 rs34353387 chr2:86974834 A/C cg25203885 chr2:87302643 LOC285074 -0.58 -9.48 -0.35 4.75e-20 Schizophrenia; BRCA cis rs6484504 0.532 rs2761589 chr11:31311429 C/G cg26647111 chr11:31128758 NA 0.45 9.8 0.36 3.31e-21 Red blood cell count; BRCA cis rs10489202 0.683 rs2294817 chr1:168073601 C/A cg24449463 chr1:168025552 DCAF6 -0.48 -15.11 -0.51 2.37e-44 Schizophrenia; BRCA cis rs4957048 0.577 rs56294732 chr5:568144 T/C cg09021430 chr5:549028 NA -0.65 -16.58 -0.55 1.34e-51 Ulcerative colitis; BRCA cis rs4803455 0.565 rs1800470 chr19:41858921 G/A cg09537434 chr19:41945824 ATP5SL -0.61 -12.73 -0.45 3.05e-33 Migraine;Coronary artery disease; BRCA cis rs17270561 0.609 rs1317817 chr6:25765377 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.1 0.37 2.35e-22 Iron status biomarkers; BRCA cis rs701145 0.730 rs701141 chr3:154061053 G/A cg17054900 chr3:154042577 DHX36 0.66 11.41 0.41 1.46e-27 Coronary artery disease; BRCA trans rs7824557 0.652 rs12677504 chr8:11133175 G/A cg06636001 chr8:8085503 FLJ10661 -0.52 -10.0 -0.37 5.51e-22 Retinal vascular caliber; BRCA cis rs17376456 0.877 rs34673483 chr5:93315079 C/A cg21475434 chr5:93447410 FAM172A 0.66 8.75 0.33 1.92e-17 Diabetic retinopathy; BRCA cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg23583168 chr7:148888333 NA -0.73 -15.55 -0.52 1.73e-46 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2712184 0.967 rs2541385 chr2:217669595 C/T cg05032264 chr2:217675019 NA -0.44 -10.95 -0.4 1.08e-25 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs4481887 1.000 rs10788775 chr1:248471945 C/G cg00666640 chr1:248458726 OR2T12 0.32 8.71 0.33 2.49e-17 Common traits (Other); BRCA cis rs67478160 0.571 rs1155751 chr14:104286547 C/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.17 -0.4 1.36e-26 Schizophrenia; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg24642844 chr7:1081250 C7orf50 -0.52 -11.2 -0.4 1.09e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2721195 0.967 rs1480000 chr8:145702007 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.6 -14.33 -0.49 1.36e-40 Age at first birth; BRCA cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg00958927 chr1:175162553 KIAA0040 -0.21 -7.85 -0.3 1.71e-14 Alcohol dependence; BRCA cis rs17270561 0.609 rs3922699 chr6:25734969 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs2580764 0.566 rs2968795 chr2:55287989 G/A cg09592903 chr2:55203963 RTN4 0.36 9.27 0.34 2.77e-19 Mean platelet volume; BRCA cis rs7927771 0.832 rs10769258 chr11:47391039 C/T cg20307385 chr11:47447363 PSMC3 0.4 8.67 0.32 3.49e-17 Subjective well-being; BRCA cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg16325326 chr1:53192061 ZYG11B -0.95 -26.34 -0.72 4.09e-104 Monocyte count; BRCA trans rs57221529 0.713 rs56328416 chr5:591138 G/A cg25482853 chr8:67687455 SGK3 0.99 15.46 0.52 5.17e-46 Lung disease severity in cystic fibrosis; BRCA cis rs9815354 0.638 rs12634670 chr3:41875299 G/C cg03022575 chr3:42003672 ULK4 0.68 9.46 0.35 5.93e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg21747090 chr2:27597821 SNX17 -0.44 -9.62 -0.36 1.51e-20 Menopause (age at onset); BRCA cis rs11247915 0.540 rs11582416 chr1:26677721 A/G cg15628303 chr1:26608928 UBXN11 -0.3 -8.03 -0.3 4.7e-15 Obesity-related traits; BRCA cis rs617791 0.530 rs10896073 chr11:65762814 T/C cg09783858 chr11:65769428 EIF1AD;BANF1 0.48 8.85 0.33 8.21e-18 Breast cancer; BRCA cis rs6063312 1.000 rs6095261 chr20:47346494 C/A cg18078177 chr20:47281410 PREX1 0.65 11.26 0.41 5.84e-27 Tonometry; BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.2 0.66 2.32e-81 Platelet count; BRCA cis rs7666738 0.752 rs62318905 chr4:99036103 T/G cg03676636 chr4:99064102 C4orf37 0.21 8.01 0.3 5.42e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3806843 0.933 rs10069930 chr5:140163328 T/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.27 -0.34 2.73e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs17345786 0.520 rs12638134 chr3:101334609 G/T cg12386194 chr3:101231763 SENP7 0.43 9.61 0.36 1.61e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11890956 chr21:40555474 PSMG1 1.06 31.74 0.78 1.95e-133 Cognitive function; BRCA cis rs2286885 1.000 rs10819169 chr9:129249625 C/T cg15282417 chr9:129245246 FAM125B 0.31 8.03 0.3 4.59e-15 Intraocular pressure; BRCA cis rs10751667 1.000 rs10902246 chr11:953674 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.9 -0.36 1.4e-21 Alzheimer's disease (late onset); BRCA cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs2153535 0.553 rs2984099 chr6:8637274 C/T cg21535247 chr6:8435926 SLC35B3 -0.66 -13.28 -0.47 1.04e-35 Motion sickness; BRCA cis rs12291225 0.679 rs7934671 chr11:14305101 C/T cg19336497 chr11:14380999 RRAS2 -0.48 -11.97 -0.43 6.18e-30 Sense of smell; BRCA cis rs11249608 0.590 rs36051170 chr5:178447971 T/C cg21905437 chr5:178450457 ZNF879 0.49 9.9 0.36 1.36e-21 Pubertal anthropometrics; BRCA cis rs7903847 0.619 rs10786336 chr10:99134953 A/C cg08345082 chr10:99160200 RRP12 -0.29 -8.6 -0.32 6.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.54 0.77 5.46e-127 Chronic sinus infection; BRCA cis rs12579753 1.000 rs2401004 chr12:82214822 T/C cg07988820 chr12:82153109 PPFIA2 -0.6 -9.71 -0.36 7.15e-21 Resting heart rate; BRCA cis rs6782228 0.606 rs9828893 chr3:128332925 T/C cg16766828 chr3:128327626 NA -0.4 -8.79 -0.33 1.33e-17 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs782590 0.967 rs17798852 chr2:55805172 A/C cg18811423 chr2:55921094 PNPT1 0.71 22.76 0.67 1.91e-84 Metabolic syndrome; BRCA cis rs477895 0.713 rs882146 chr11:63976699 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.82 0.45 1.18e-33 Mean platelet volume; BRCA cis rs16944613 0.541 rs4566137 chr15:91097964 A/G cg26821196 chr15:91095069 CRTC3 0.48 8.77 0.33 1.57e-17 Colorectal cancer; BRCA cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg22800045 chr5:56110881 MAP3K1 -0.5 -8.21 -0.31 1.19e-15 Initial pursuit acceleration; BRCA cis rs6088580 0.634 rs6059890 chr20:33101653 G/C cg08999081 chr20:33150536 PIGU 0.46 12.92 0.46 4.19e-34 Glomerular filtration rate (creatinine); BRCA cis rs739401 0.611 rs450817 chr11:3056712 A/G cg05729581 chr11:3078854 CARS -0.33 -8.28 -0.31 7.32e-16 Longevity; BRCA cis rs6582630 0.555 rs10880421 chr12:38423015 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.24 0.38 7e-23 Drug-induced liver injury (flucloxacillin); BRCA trans rs9325144 0.600 rs7965877 chr12:38743697 G/T cg23762105 chr12:34175262 ALG10 -0.37 -9.47 -0.35 5.25e-20 Morning vs. evening chronotype; BRCA cis rs61931739 0.517 rs1843737 chr12:34015305 A/G cg06521331 chr12:34319734 NA -0.52 -10.42 -0.38 1.42e-23 Morning vs. evening chronotype; BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg16606324 chr3:10149918 C3orf24 0.56 10.85 0.39 2.78e-25 Alzheimer's disease; BRCA cis rs4074536 0.574 rs10737733 chr1:116288825 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs6669008 1.000 rs6669008 chr1:114166561 A/G cg26035817 chr1:114414802 PTPN22 0.34 8.2 0.31 1.28e-15 Bacteremia; BRCA cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg26818010 chr10:134567672 INPP5A -0.63 -13.98 -0.48 5.91e-39 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs826838 0.935 rs1684407 chr12:39127270 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.21 -0.54 8.87e-50 Heart rate; BRCA cis rs16958440 0.867 rs28587821 chr18:44687906 G/A cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs4819052 1.000 rs2838830 chr21:46664227 T/G cg11663144 chr21:46675770 NA -0.48 -9.73 -0.36 6.13e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs992157 0.661 rs17653757 chr2:219109364 G/C cg00012203 chr2:219082015 ARPC2 0.72 16.43 0.54 7.67e-51 Colorectal cancer; BRCA cis rs3741404 0.825 rs11603538 chr11:63986713 C/A cg18225595 chr11:63971243 STIP1 0.53 13.14 0.46 4.21e-35 Platelet count; BRCA cis rs858239 0.738 rs13225593 chr7:23260307 A/G cg23682824 chr7:23144976 KLHL7 0.36 9.31 0.35 2.02e-19 Cerebrospinal fluid biomarker levels; BRCA cis rs17490626 0.568 rs12413523 chr10:71211664 C/G cg12610070 chr10:71211762 TSPAN15 -0.33 -11.77 -0.42 4.44e-29 Thrombosis; BRCA cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg03146154 chr1:46216737 IPP 0.54 12.03 0.43 3.34e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs735860 0.737 rs2115564 chr6:53173482 C/A cg10236188 chr6:53219634 NA -0.41 -8.81 -0.33 1.21e-17 Glaucoma; BRCA cis rs35306767 0.761 rs34480046 chr10:1027440 A/G cg18964960 chr10:1102726 WDR37 0.6 8.04 0.3 4.44e-15 Eosinophil percentage of granulocytes; BRCA cis rs798554 0.679 rs11973498 chr7:2886873 C/A cg19346786 chr7:2764209 NA -0.3 -9.4 -0.35 9.79e-20 Height; BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.32 -0.44 1.9e-31 Alzheimer's disease; BRCA cis rs58688157 0.705 rs12419720 chr11:598205 C/G cg16486109 chr11:613632 IRF7 0.42 8.83 0.33 1.01e-17 Systemic lupus erythematosus; BRCA cis rs9487051 1.000 rs6568569 chr6:109613196 C/A cg21918786 chr6:109611834 NA -0.44 -11.8 -0.42 3.23e-29 Reticulocyte fraction of red cells; BRCA cis rs858239 0.600 rs13438188 chr7:23144197 C/T cg23682824 chr7:23144976 KLHL7 -0.4 -10.44 -0.38 1.17e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs7647973 0.731 rs7617480 chr3:49210732 G/T cg07636037 chr3:49044803 WDR6 -0.69 -14.02 -0.49 3.91e-39 Menarche (age at onset); BRCA cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg17158414 chr2:27665306 KRTCAP3 -0.32 -8.16 -0.31 1.78e-15 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg22117172 chr7:91764530 CYP51A1 0.24 8.11 0.31 2.51e-15 Breast cancer; BRCA cis rs7395581 0.918 rs10742799 chr11:47293702 T/C cg25783544 chr11:47291846 MADD 0.43 9.65 0.36 1.13e-20 HDL cholesterol; BRCA cis rs10189230 0.967 rs13012429 chr2:222350788 C/T cg14652038 chr2:222343519 EPHA4 0.48 13.26 0.46 1.3e-35 Urate levels in lean individuals; BRCA cis rs881375 0.967 rs1930780 chr9:123686219 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.55 0.32 8.8e-17 Rheumatoid arthritis; BRCA cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg12935359 chr14:103987150 CKB -0.58 -13.24 -0.46 1.58e-35 Body mass index; BRCA cis rs6964587 1.000 rs2269727 chr7:91752690 C/A cg01689657 chr7:91764605 CYP51A1 0.23 8.37 0.31 3.68e-16 Breast cancer; BRCA cis rs6121246 0.559 rs6060944 chr20:30372114 G/A cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA cis rs9291683 0.566 rs13122689 chr4:10044648 A/G cg00071950 chr4:10020882 SLC2A9 0.55 13.19 0.46 2.62e-35 Bone mineral density; BRCA cis rs6840258 0.660 rs72667739 chr4:87877499 A/C cg08197287 chr4:87952173 AFF1 -0.47 -8.47 -0.32 1.71e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA trans rs66887589 0.870 rs59590064 chr4:120539753 T/C cg25214090 chr10:38739885 LOC399744 -0.34 -7.85 -0.3 1.73e-14 Diastolic blood pressure; BRCA cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg01579765 chr21:45077557 HSF2BP -0.46 -12.54 -0.44 2.01e-32 Mean corpuscular volume; BRCA cis rs701145 0.556 rs355762 chr3:154012614 G/A cg12800244 chr3:153838788 SGEF 0.42 8.45 0.32 2.03e-16 Coronary artery disease; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg26395211 chr5:140044315 WDR55 0.35 7.9 0.3 1.24e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg26384229 chr12:38710491 ALG10B 0.7 15.74 0.53 2.14e-47 Bladder cancer; BRCA cis rs7737355 0.898 rs31590 chr5:131005181 A/G cg06307176 chr5:131281290 NA 0.52 10.23 0.38 7.41e-23 Life satisfaction; BRCA cis rs1969363 0.531 rs11495331 chr12:38110702 A/G cg26384229 chr12:38710491 ALG10B 0.44 9.81 0.36 3.06e-21 Morning vs. evening chronotype; BRCA cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.77 0.5 1.1e-42 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2882667 0.690 rs288040 chr5:138204894 A/T cg04439458 chr5:138467593 SIL1 -0.35 -8.55 -0.32 9.12e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs17270561 0.636 rs1185977 chr6:25829054 A/G cg17691542 chr6:26056736 HIST1H1C 0.44 9.59 0.35 1.87e-20 Iron status biomarkers; BRCA cis rs853679 0.517 rs9380058 chr6:28127444 T/C cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.37e-15 Depression; BRCA cis rs62229266 0.839 rs11088335 chr21:37470335 C/T cg12218747 chr21:37451666 NA -0.36 -8.65 -0.32 4.01e-17 Mitral valve prolapse; BRCA cis rs6840360 0.593 rs2175409 chr4:152701656 A/G cg22705602 chr4:152727874 NA -0.39 -10.68 -0.39 1.27e-24 Intelligence (multi-trait analysis); BRCA cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06544989 chr22:39130855 UNC84B 0.38 8.75 0.33 1.89e-17 Menopause (age at onset); BRCA cis rs1580019 0.563 rs2392071 chr7:32572536 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.3 0.76 2.96e-120 Cognitive ability; BRCA cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg13319975 chr6:146136371 FBXO30 -0.63 -14.66 -0.5 3.8e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742234 0.910 rs2503866 chr10:43646261 T/A cg15436174 chr10:43711423 RASGEF1A -0.43 -9.15 -0.34 7.36e-19 Hirschsprung disease; BRCA cis rs7582180 0.652 rs11123830 chr2:100974747 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.5 0.41 5.86e-28 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.699 rs6449174 chr4:9966422 C/T cg26043149 chr18:55253948 FECH -0.37 -8.17 -0.31 1.63e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs208515 0.556 rs10455193 chr6:66691456 G/A cg07460842 chr6:66804631 NA 0.88 15.61 0.53 8.47e-47 Exhaled nitric oxide levels; BRCA cis rs9790314 1.000 rs975323 chr3:161021322 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.0 -0.48 4.87e-39 Morning vs. evening chronotype; BRCA trans rs6582630 0.555 rs10880421 chr12:38423015 C/T cg06521331 chr12:34319734 NA -0.51 -9.21 -0.34 4.77e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs8114671 0.552 rs2024635 chr20:33422614 G/A cg24642439 chr20:33292090 TP53INP2 0.41 8.66 0.32 3.76e-17 Height; BRCA cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg25427524 chr10:38739819 LOC399744 -0.64 -15.09 -0.51 3.06e-44 Extrinsic epigenetic age acceleration; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg00080972 chr5:178986291 RUFY1 -0.52 -14.83 -0.51 5.36e-43 Lung cancer; BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg24082983 chr21:31802169 KRTAP13-4 0.34 8.59 0.32 6.86e-17 HDL cholesterol; BRCA cis rs7824557 0.767 rs2164273 chr8:11168499 A/G cg21775007 chr8:11205619 TDH 0.6 12.08 0.43 2.12e-30 Retinal vascular caliber; BRCA cis rs483180 0.511 rs496198 chr1:120207177 A/G cg19096424 chr1:120255104 PHGDH -0.42 -9.3 -0.35 2.12e-19 Macular telangiectasia type 2; BRCA cis rs6834538 0.597 rs4834291 chr4:113482718 C/T cg05166686 chr4:113558556 LARP7;C4orf21 0.44 10.6 0.39 2.69e-24 Free thyroxine concentration; BRCA cis rs13256369 1.000 rs7843488 chr8:8576217 C/T cg18904891 chr8:8559673 CLDN23 0.59 11.31 0.41 3.67e-27 Obesity-related traits; BRCA cis rs4718428 0.705 rs4718422 chr7:66359269 A/G cg18252515 chr7:66147081 NA -0.55 -11.03 -0.4 4.99e-26 Corneal structure; BRCA cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg06640241 chr16:89574553 SPG7 0.76 17.84 0.58 4.62e-58 Multiple myeloma (IgH translocation); BRCA cis rs9291683 0.546 rs13120348 chr4:10053155 C/G cg11266682 chr4:10021025 SLC2A9 -0.45 -11.96 -0.43 6.58e-30 Bone mineral density; BRCA cis rs312274 0.698 rs1854482 chr12:41212586 A/G cg17827154 chr12:41323612 CNTN1 0.36 8.82 0.33 1.06e-17 Metabolite levels (X-11787); BRCA cis rs3772130 0.564 rs28760466 chr3:121601510 A/G cg20356878 chr3:121714668 ILDR1 0.43 9.98 0.37 6.6e-22 Cognitive performance; BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg14820908 chr5:178986412 RUFY1 0.44 11.18 0.4 1.24e-26 Lung cancer; BRCA cis rs4363385 0.747 rs6684188 chr1:152974285 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.84 -0.36 2.35e-21 Inflammatory skin disease; BRCA cis rs1577917 0.518 rs6454482 chr6:86418188 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.32 8.84 0.33 9.03e-18 Response to antipsychotic treatment; BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 22.34 0.66 4e-82 Platelet count; BRCA cis rs11758351 0.660 rs113208674 chr6:26210465 C/G cg01420254 chr6:26195488 NA 0.55 8.58 0.32 7.05e-17 Gout;Renal underexcretion gout; BRCA cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg01256987 chr12:42539512 GXYLT1 -0.56 -11.41 -0.41 1.37e-27 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs11577318 0.853 rs4333841 chr1:26631927 T/C cg04990556 chr1:26633338 UBXN11 -0.47 -9.28 -0.34 2.53e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs765787 0.530 rs11854689 chr15:45516052 A/G cg15395560 chr15:45543142 SLC28A2 0.3 8.3 0.31 6.2e-16 Uric acid levels; BRCA cis rs66731853 0.769 rs476582 chr1:20894450 A/G cg04087271 chr1:20915334 CDA -0.47 -9.03 -0.34 1.97e-18 Mean corpuscular volume; BRCA cis rs7937682 0.961 rs7106104 chr11:111635655 T/C cg09085632 chr11:111637200 PPP2R1B 1.0 23.81 0.69 3.45e-90 Primary sclerosing cholangitis; BRCA cis rs1712517 0.873 rs7913461 chr10:105001325 A/G cg05636881 chr10:105038444 INA 0.36 8.05 0.3 4.17e-15 Migraine; BRCA cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg02475777 chr4:1388615 CRIPAK 0.68 13.05 0.46 1.08e-34 Longevity; BRCA cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 10.01 0.37 5.23e-22 Tonsillectomy; BRCA cis rs586533 0.881 rs1628747 chr11:99507950 C/T cg22878054 chr11:99397252 CNTN5 0.31 7.88 0.3 1.46e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg02297831 chr4:17616191 MED28 0.37 8.56 0.32 8.7e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6430585 0.583 rs12373779 chr2:136586840 A/C cg07169764 chr2:136633963 MCM6 1.25 30.25 0.77 1.89e-125 Corneal structure; BRCA cis rs2832191 1.000 rs2832185 chr21:30483761 C/G cg08807101 chr21:30365312 RNF160 -0.57 -13.87 -0.48 2.01e-38 Dental caries; BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.69 -11.74 -0.42 5.92e-29 Platelet count; BRCA cis rs7086627 0.515 rs10887899 chr10:82210214 G/A cg00277334 chr10:82204260 NA -0.85 -24.82 -0.7 9.19e-96 Post bronchodilator FEV1; BRCA cis rs9487051 0.660 rs2884036 chr6:109642916 A/G cg01475377 chr6:109611718 NA 0.49 11.51 0.41 5.29e-28 Reticulocyte fraction of red cells; BRCA cis rs17604090 0.793 rs10226095 chr7:29690059 A/G cg19413766 chr7:29689036 LOC646762 0.48 7.84 0.3 1.85e-14 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg12419862 chr22:24373484 LOC391322 0.69 15.57 0.52 1.4e-46 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs8114671 0.836 rs6142294 chr20:33671497 A/G cg07148914 chr20:33460835 GGT7 -0.43 -9.15 -0.34 7.77e-19 Height; BRCA cis rs11190604 1.000 rs7080356 chr10:102266735 A/C cg07080220 chr10:102295463 HIF1AN 0.59 14.22 0.49 4.51e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10504229 1.000 rs72652906 chr8:58188360 C/A cg05313129 chr8:58192883 C8orf71 -0.46 -9.53 -0.35 3.34e-20 Developmental language disorder (linguistic errors); BRCA cis rs3806933 0.522 rs13153937 chr5:110434307 C/T cg04022379 chr5:110408740 TSLP 0.48 10.67 0.39 1.45e-24 Eosinophilic esophagitis; BRCA cis rs16854884 0.657 rs7642774 chr3:143723272 T/A cg06585982 chr3:143692056 C3orf58 0.43 8.92 0.33 4.69e-18 Economic and political preferences (feminism/equality); BRCA cis rs4363385 0.747 rs2339495 chr1:152975116 A/T cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg13073564 chr4:8508604 NA 0.43 11.63 0.42 1.79e-28 Response to antineoplastic agents; BRCA cis rs13040088 0.872 rs13039291 chr20:61572760 C/T cg23096297 chr20:61557774 DIDO1 0.9 17.35 0.57 1.54e-55 Menopause (age at onset); BRCA cis rs12477438 0.734 rs4851184 chr2:99666434 T/C cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA trans rs2562456 0.876 rs62110202 chr19:21754601 C/T cg25042112 chr7:64838748 ZNF92 -0.43 -8.27 -0.31 7.53e-16 Pain; BRCA cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg12310025 chr6:25882481 NA -0.52 -11.79 -0.42 3.63e-29 Intelligence (multi-trait analysis); BRCA trans rs11039798 0.920 rs11040015 chr11:48783130 G/T cg15704280 chr7:45808275 SEPT13 0.58 8.7 0.33 2.84e-17 Axial length; BRCA trans rs4596713 0.568 rs7034179 chr9:71746838 C/T cg16512924 chr15:28394682 HERC2 0.4 9.56 0.35 2.47e-20 Headache; BRCA cis rs13256369 1.000 rs12550458 chr8:8567832 G/A cg18904891 chr8:8559673 CLDN23 0.64 12.43 0.44 6.37e-32 Obesity-related traits; BRCA cis rs7618501 0.602 rs2013208 chr3:50129399 C/T cg14019146 chr3:50243930 SLC38A3 0.34 8.03 0.3 4.59e-15 Intelligence (multi-trait analysis); BRCA cis rs7683537 0.501 rs2171838 chr4:185667404 A/G cg04058563 chr4:185651563 MLF1IP -0.57 -11.41 -0.41 1.38e-27 Systemic lupus erythematosus; BRCA cis rs9612 0.950 rs11351 chr19:44271066 A/C cg08581076 chr19:44259116 C19orf61 0.47 8.82 0.33 1.05e-17 Exhaled nitric oxide output; BRCA cis rs3768617 0.528 rs10911240 chr1:183062948 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 18.03 0.58 4.79e-59 Fuchs's corneal dystrophy; BRCA cis rs36051895 0.632 rs7030853 chr9:5179002 C/T cg02405213 chr9:5042618 JAK2 -0.47 -8.82 -0.33 1.07e-17 Pediatric autoimmune diseases; BRCA cis rs965469 1.000 rs6051732 chr20:3294182 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -10.42 -0.38 1.39e-23 IFN-related cytopenia; BRCA cis rs34172651 0.517 rs7204288 chr16:24784531 A/G cg00339695 chr16:24857497 SLC5A11 0.52 11.02 0.4 5.61e-26 Intelligence (multi-trait analysis); BRCA cis rs344364 0.511 rs56077812 chr16:1948870 T/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg13010199 chr12:38710504 ALG10B 0.51 9.97 0.37 7.46e-22 Bladder cancer; BRCA cis rs17023223 0.537 rs10923759 chr1:119692194 A/G cg05756136 chr1:119680316 WARS2 0.43 8.33 0.31 4.97e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg16586182 chr3:47516702 SCAP 0.44 8.91 0.33 5.2e-18 Birth weight; BRCA cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg09658497 chr7:2847517 GNA12 -0.39 -8.02 -0.3 5.01e-15 Height; BRCA cis rs6963495 0.818 rs73192124 chr7:105171528 C/T cg19920283 chr7:105172520 RINT1 0.59 9.22 0.34 4.15e-19 Bipolar disorder (body mass index interaction); BRCA cis rs473651 0.935 rs508483 chr2:239339709 T/C cg14266287 chr2:239334506 ASB1 -0.33 -8.03 -0.3 4.64e-15 Multiple system atrophy; BRCA cis rs61990749 0.544 rs11628888 chr14:78161506 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.62 -9.52 -0.35 3.62e-20 Fibroblast growth factor basic levels; BRCA cis rs867371 1.000 rs7181655 chr15:82455616 T/C cg00614314 chr15:82944287 LOC80154 0.44 9.12 0.34 9.34e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA trans rs9650657 0.529 rs10108618 chr8:10953092 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -11.67 -0.42 1.2e-28 Neuroticism; BRCA trans rs2270927 0.510 rs2913265 chr5:75603886 C/A cg13563193 chr19:33072644 PDCD5 0.93 10.48 0.38 8.24e-24 Mean corpuscular volume; BRCA cis rs7903847 0.642 rs11817875 chr10:99158414 G/A cg08345082 chr10:99160200 RRP12 -0.31 -8.89 -0.33 6.36e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs35123781 1.000 rs589153 chr5:139057548 A/G cg05227215 chr5:139057496 CXXC5 0.33 8.06 0.3 3.89e-15 Schizophrenia; BRCA cis rs2882667 0.858 rs11242444 chr5:138406379 T/A cg04439458 chr5:138467593 SIL1 -0.43 -10.8 -0.39 4.4e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1707322 1.000 rs11211190 chr1:46266255 C/T cg06784218 chr1:46089804 CCDC17 0.46 10.91 0.4 1.58e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1555322 0.530 rs6060341 chr20:33863633 C/T cg17927777 chr20:33865990 NA -0.49 -9.58 -0.35 2.07e-20 Attention deficit hyperactivity disorder; BRCA cis rs2354432 0.607 rs7553584 chr1:146693429 A/G cg25205988 chr1:146714368 CHD1L -0.86 -10.94 -0.4 1.19e-25 Mitochondrial DNA levels; BRCA cis rs8038465 0.568 rs62004592 chr15:73878019 A/G cg15420318 chr15:73925796 NPTN 0.47 10.08 0.37 2.74e-22 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg04546413 chr19:29218101 NA 0.64 12.29 0.44 2.61e-31 Methadone dose in opioid dependence; BRCA cis rs17095355 1.000 rs17126886 chr10:111695257 G/C cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.05 -0.37 3.83e-22 Biliary atresia; BRCA cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg08859206 chr1:53392774 SCP2 0.49 10.84 0.39 2.91e-25 Monocyte count; BRCA cis rs67478160 0.643 rs12880167 chr14:104300829 C/T cg08213375 chr14:104286397 PPP1R13B 0.65 18.16 0.58 9.46e-60 Schizophrenia; BRCA trans rs877282 0.947 rs7904978 chr10:768078 C/T cg22713356 chr15:30763199 NA 1.35 26.99 0.73 1.24e-107 Uric acid levels; BRCA cis rs9649465 1.000 rs1006764 chr7:123337873 C/T cg04330084 chr7:123175371 IQUB -0.3 -8.32 -0.31 5.51e-16 Migraine; BRCA cis rs4302748 0.865 rs59011914 chr7:36185290 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs1691799 0.867 rs1027399 chr12:66760942 G/A cg16791601 chr12:66731901 HELB -0.65 -17.62 -0.57 6.52e-57 White blood cell count (basophil); BRCA cis rs1003719 0.788 rs8133549 chr21:38447489 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.17 0.49 7.56e-40 Eye color traits; BRCA cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg13628971 chr7:2884303 GNA12 0.6 13.71 0.48 1.12e-37 Height; BRCA cis rs35110281 0.713 rs1378079 chr21:45011187 A/G cg01579765 chr21:45077557 HSF2BP -0.39 -10.46 -0.38 9.8599999999999993e-24 Mean corpuscular volume; BRCA cis rs1801251 0.896 rs7573208 chr2:233696701 C/A cg08000102 chr2:233561755 GIGYF2 -0.6 -13.4 -0.47 2.85e-36 Coronary artery disease; BRCA cis rs12497850 0.931 rs9311434 chr3:48884147 T/C cg07636037 chr3:49044803 WDR6 0.94 27.28 0.73 2.99e-109 Parkinson's disease; BRCA cis rs12458462 0.509 rs3786241 chr18:77494328 A/C cg11879182 chr18:77439856 CTDP1 0.43 9.49 0.35 4.58e-20 Monocyte count; BRCA cis rs2243480 1.000 rs160644 chr7:65558186 C/T cg18252515 chr7:66147081 NA -1.07 -15.54 -0.52 2.03e-46 Diabetic kidney disease; BRCA cis rs4363385 0.818 rs382292 chr1:153006641 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.18e-19 Inflammatory skin disease; BRCA cis rs12893668 0.603 rs61637848 chr14:104096031 C/T cg08213375 chr14:104286397 PPP1R13B 0.4 8.47 0.32 1.68e-16 Reticulocyte count; BRCA cis rs12997796 0.556 rs35129240 chr2:86929217 G/A cg25203885 chr2:87302643 LOC285074 -0.59 -9.49 -0.35 4.46e-20 Schizophrenia; BRCA cis rs908922 0.628 rs488393 chr1:152489548 C/T cg20991723 chr1:152506922 NA 0.39 9.12 0.34 9.93e-19 Hair morphology; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg13902645 chr11:5959945 NA -0.57 -11.54 -0.42 4e-28 DNA methylation (variation); BRCA cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.31 0.66 5.54e-82 Chronic sinus infection; BRCA cis rs514406 0.929 rs555741 chr1:53318851 T/G cg08859206 chr1:53392774 SCP2 -0.51 -11.23 -0.41 7.8e-27 Monocyte count; BRCA cis rs1499972 0.941 rs62263119 chr3:117630175 T/G cg07612923 chr3:117604196 NA 0.6 8.15 0.31 1.97e-15 Schizophrenia; BRCA cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg11062466 chr8:58055876 NA 0.41 7.93 0.3 9.62e-15 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.846 rs12495310 chr3:160970956 T/A cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA cis rs4319547 1.000 rs7295397 chr12:123116209 C/T cg23029597 chr12:123009494 RSRC2 -0.6 -12.19 -0.43 6.73e-31 Body mass index; BRCA cis rs4478858 0.611 rs10914338 chr1:31733782 T/A cg00250761 chr1:31883323 NA -0.32 -8.26 -0.31 8.51e-16 Alcohol dependence; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg04944784 chr2:26401820 FAM59B -0.95 -16.25 -0.54 5.83e-50 Gut microbiome composition (summer); BRCA cis rs2404602 0.684 rs2047504 chr15:76883516 A/T cg23625390 chr15:77176239 SCAPER -0.54 -13.38 -0.47 3.74e-36 Blood metabolite levels; BRCA cis rs804280 0.565 rs1466785 chr8:11623456 C/T cg12395012 chr8:11607386 GATA4 -0.37 -8.5 -0.32 1.31e-16 Myopia (pathological); BRCA cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg04546413 chr19:29218101 NA 0.68 13.89 0.48 1.64e-38 Methadone dose in opioid dependence; BRCA cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg01884057 chr2:25150051 NA 0.34 9.22 0.34 4.21e-19 Body mass index; BRCA cis rs2282802 0.711 rs1864970 chr5:139633042 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.31 0.31 5.88e-16 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg11764359 chr7:65958608 NA -0.61 -13.38 -0.47 3.61e-36 Aortic root size; BRCA cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg20701182 chr2:24300061 SF3B14 0.67 9.77 0.36 4.1e-21 Lymphocyte counts; BRCA cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg11266682 chr4:10021025 SLC2A9 0.5 13.18 0.46 3.04e-35 Bone mineral density; BRCA cis rs7267979 0.903 rs6050482 chr20:25226327 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.29 8.04 0.3 4.31e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg03709012 chr19:19516395 GATAD2A 0.72 15.68 0.53 4.14e-47 Tonsillectomy; BRCA cis rs4919694 0.908 rs11191523 chr10:104792400 A/G cg04362960 chr10:104952993 NT5C2 0.94 14.51 0.5 1.96e-41 Arsenic metabolism; BRCA cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg12311346 chr5:56204834 C5orf35 -0.79 -16.15 -0.54 1.8e-49 Initial pursuit acceleration; BRCA cis rs652260 0.819 rs55656533 chr19:7902976 G/C cg26014689 chr19:7917955 EVI5L -0.51 -11.65 -0.42 1.46e-28 Menarche (age at onset); BRCA cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg20503657 chr10:835505 NA 1.04 17.35 0.57 1.6e-55 Eosinophil percentage of granulocytes; BRCA cis rs6964587 0.967 rs34863529 chr7:91644341 C/G cg01689657 chr7:91764605 CYP51A1 0.23 8.09 0.3 2.93e-15 Breast cancer; BRCA cis rs2439831 0.850 rs12442129 chr15:44055856 C/T cg10011062 chr15:43941034 CATSPER2 -0.53 -7.98 -0.3 6.85e-15 Lung cancer in ever smokers; BRCA cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.2 0.46 2.35e-35 Bipolar disorder; BRCA cis rs694739 0.628 rs508168 chr11:64135435 G/A cg23796481 chr11:64053134 BAD;GPR137 0.5 10.52 0.38 5.6e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02475777 chr4:1388615 CRIPAK -0.54 -10.6 -0.39 2.69e-24 Longevity; BRCA cis rs8017423 0.615 rs12586761 chr14:90820897 A/G cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs11098499 0.691 rs9995716 chr4:120264996 T/C cg09307838 chr4:120376055 NA 0.6 13.0 0.46 1.91e-34 Corneal astigmatism; BRCA cis rs2382817 0.580 rs6756265 chr2:219095554 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.26 -0.34 3.09e-19 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs838147 0.508 rs507711 chr19:49208564 C/T cg07051648 chr19:49177693 NTN5;SEC1 -0.43 -8.06 -0.3 3.74e-15 Dietary macronutrient intake; BRCA cis rs11711311 1.000 rs12695295 chr3:113474866 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.49 0.35 4.68e-20 IgG glycosylation; BRCA cis rs6598955 0.671 rs6681452 chr1:26621101 G/A cg00852783 chr1:26633632 UBXN11 -0.48 -8.52 -0.32 1.17e-16 Obesity-related traits; BRCA cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.61e-27 Extrinsic epigenetic age acceleration; BRCA cis rs1568889 1.000 rs7945367 chr11:28166272 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 14.88 0.51 3.26e-43 Bipolar disorder; BRCA cis rs10504229 0.906 rs114810777 chr8:58185298 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.71 -0.36 6.79e-21 Developmental language disorder (linguistic errors); BRCA cis rs6430585 0.528 rs3112496 chr2:136711064 C/T cg07169764 chr2:136633963 MCM6 1.01 21.03 0.64 5.41e-75 Corneal structure; BRCA cis rs6089829 0.925 rs3746748 chr20:61667526 C/T cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2230307 0.656 rs568089 chr1:100495392 A/G cg24955406 chr1:100503596 HIAT1 0.47 7.92 0.3 1.04e-14 Carotid intima media thickness; BRCA cis rs7520050 0.553 rs2993263 chr1:46021630 A/G cg24296786 chr1:45957014 TESK2 -0.55 -13.31 -0.47 7.59e-36 Red blood cell count;Reticulocyte count; BRCA cis rs7246657 0.722 rs1975937 chr19:38091932 A/T cg23950597 chr19:37808831 NA -0.5 -8.57 -0.32 7.48e-17 Coronary artery calcification; BRCA cis rs7043114 0.525 rs10820969 chr9:95106678 G/C cg14631576 chr9:95140430 CENPP -0.34 -8.38 -0.31 3.29e-16 Height; BRCA trans rs2727020 0.635 rs7124266 chr11:49280857 T/G cg15704280 chr7:45808275 SEPT13 0.76 16.05 0.54 6.08e-49 Coronary artery disease; BRCA cis rs9790314 0.503 rs6441374 chr3:161064540 A/T cg03342759 chr3:160939853 NMD3 -0.72 -15.7 -0.53 3.19e-47 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs6050564 chr20:25344231 G/A cg08601574 chr20:25228251 PYGB -0.34 -8.18 -0.31 1.53e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2032447 0.869 rs199752 chr6:26012875 C/T cg03517284 chr6:25882590 NA -0.49 -10.08 -0.37 2.78e-22 Intelligence (multi-trait analysis); BRCA cis rs9858542 0.537 rs67882627 chr3:49380441 A/T cg00383909 chr3:49044727 WDR6 0.52 10.26 0.38 5.98e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg11707556 chr5:10655725 ANKRD33B -0.48 -12.5 -0.44 3.15e-32 Height; BRCA cis rs6815814 0.950 rs114719937 chr4:38808585 G/C cg02016764 chr4:38805732 TLR1 -0.6 -9.49 -0.35 4.33e-20 Breast cancer; BRCA trans rs6951245 0.572 rs79489623 chr7:1045632 C/T cg13565492 chr6:43139072 SRF -0.78 -7.95 -0.3 8.28e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6460942 0.915 rs6968695 chr7:12443878 G/C cg06484146 chr7:12443880 VWDE -0.73 -11.02 -0.4 5.45e-26 Coronary artery disease; BRCA cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg11644478 chr21:40555479 PSMG1 -0.53 -11.32 -0.41 3.27e-27 Menarche (age at onset); BRCA cis rs250677 0.687 rs250663 chr5:148453117 T/C cg23229984 chr5:148520753 ABLIM3 0.35 8.77 0.33 1.66e-17 Breast cancer; BRCA cis rs2204008 0.580 rs11174421 chr12:38105138 A/G cg26384229 chr12:38710491 ALG10B 0.69 14.85 0.51 4.42e-43 Bladder cancer; BRCA cis rs11785693 0.862 rs62491171 chr8:4987177 G/A cg26367366 chr8:4980734 NA 0.63 11.43 0.41 1.18e-27 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs4862750 0.872 rs11947595 chr4:187899827 C/T cg22105103 chr4:187893119 NA 0.41 13.27 0.46 1.16e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs495337 1.000 rs4809769 chr20:48579164 C/A cg17835207 chr20:48524531 SPATA2 -0.58 -13.13 -0.46 4.95e-35 Psoriasis; BRCA cis rs3806843 0.735 rs2530235 chr5:140072647 G/T cg16179182 chr5:140090404 VTRNA1-1 0.47 10.98 0.4 8.03e-26 Depressive symptoms (multi-trait analysis); BRCA cis rs56235845 0.694 rs11748912 chr5:176765395 G/A cg16006841 chr5:176797999 RGS14 0.59 11.75 0.42 5.33e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg23358479 chr7:1110784 C7orf50 -0.47 -7.95 -0.3 8.75e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg22963979 chr7:1858916 MAD1L1 -0.38 -8.17 -0.31 1.61e-15 Bipolar disorder and schizophrenia; BRCA cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg13752114 chr3:195489708 MUC4 0.52 8.56 0.32 8.65e-17 Lung disease severity in cystic fibrosis; BRCA cis rs6582630 0.562 rs35080195 chr12:38310866 G/A cg26384229 chr12:38710491 ALG10B -0.43 -10.05 -0.37 3.79e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs6750047 0.628 rs2855655 chr2:38304488 T/C cg07380506 chr2:38303506 CYP1B1 0.49 11.27 0.41 5.52e-27 Cutaneous malignant melanoma;Melanoma; BRCA cis rs13064411 0.542 rs13082603 chr3:113223362 T/C cg18753928 chr3:113234510 CCDC52 -0.45 -9.6 -0.35 1.8e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs477692 0.629 rs945231 chr10:131294827 A/G cg24747557 chr10:131355152 MGMT -0.35 -8.08 -0.3 3.14e-15 Response to temozolomide; BRCA cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg02659138 chr7:134003124 SLC35B4 0.34 10.47 0.38 8.85e-24 Mean platelet volume; BRCA cis rs7267979 0.866 rs437635 chr20:25456888 A/G cg08601574 chr20:25228251 PYGB 0.34 8.36 0.31 3.94e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10911251 0.528 rs2093982 chr1:183094191 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Colorectal cancer; BRCA cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg15017067 chr4:17643749 FAM184B 0.34 10.6 0.39 2.63e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12760731 0.565 rs7550699 chr1:178209584 T/G cg00404053 chr1:178313656 RASAL2 0.65 7.86 0.3 1.68e-14 Obesity-related traits; BRCA cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg22875332 chr1:76189707 ACADM 0.66 15.78 0.53 1.35e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs737008 1.000 rs737008 chr16:11374866 G/T cg00044050 chr16:11439710 C16orf75 -0.36 -7.82 -0.3 2.26e-14 Obesity-related traits; BRCA cis rs9287719 0.967 rs2010080 chr2:10736552 A/T cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs826838 1.000 rs7975243 chr12:38849220 C/T cg13010199 chr12:38710504 ALG10B 0.56 12.22 0.44 5.11e-31 Heart rate; BRCA cis rs6582630 0.555 rs34730221 chr12:38405140 C/T cg13010199 chr12:38710504 ALG10B -0.39 -8.46 -0.32 1.78e-16 Drug-induced liver injury (flucloxacillin); BRCA trans rs12310956 0.532 rs11052933 chr12:33969881 G/A cg26384229 chr12:38710491 ALG10B 0.66 13.92 0.48 1.18e-38 Morning vs. evening chronotype; BRCA cis rs9399135 0.967 rs9399129 chr6:135285148 C/A cg24558204 chr6:135376177 HBS1L 0.45 12.24 0.44 4.21e-31 Red blood cell count; BRCA trans rs3749237 0.964 rs35210174 chr3:49812606 C/T cg21659725 chr3:3221576 CRBN 0.5 11.8 0.42 3.17e-29 Resting heart rate; BRCA cis rs1506403 0.685 rs10281506 chr7:142823928 C/T cg21852589 chr7:142981689 TMEM139 0.4 7.89 0.3 1.34e-14 Cancer; BRCA cis rs8177253 0.761 rs1830084 chr3:133508464 A/T cg01448562 chr3:133502909 NA 0.75 19.56 0.61 4.2e-67 Iron status biomarkers; BRCA cis rs11605924 0.901 rs7112505 chr11:45840939 A/T ch.11.939596F chr11:45881766 CRY2 -0.44 -9.64 -0.36 1.31e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs651907 0.535 rs34648996 chr3:101511202 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.45 0.5 3.64e-41 Colorectal cancer; BRCA cis rs35110281 0.774 rs2838323 chr21:44999086 G/A cg21573476 chr21:45109991 RRP1B -0.35 -9.05 -0.34 1.67e-18 Mean corpuscular volume; BRCA cis rs6912958 0.559 rs242270 chr6:88062190 C/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.38 -11.17 -0.4 1.36e-26 Monocyte percentage of white cells; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg19346786 chr7:2764209 NA -0.33 -9.86 -0.36 1.98e-21 Height; BRCA cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg08859206 chr1:53392774 SCP2 -0.42 -8.46 -0.32 1.84e-16 Monocyte count; BRCA cis rs4975709 0.610 rs6886669 chr5:1867830 T/C cg15595755 chr5:1867978 NA 0.35 8.34 0.31 4.67e-16 Cardiovascular disease risk factors; BRCA cis rs10193935 0.901 rs10174872 chr2:42459807 T/G cg27598129 chr2:42591480 NA -0.97 -15.01 -0.51 7.46e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs3760982 0.585 rs62116964 chr19:44291986 T/C cg12072164 chr19:44306565 LYPD5 0.37 8.73 0.33 2.23e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs4363385 0.693 rs582345 chr1:153033406 G/A cg24667326 chr1:152973720 SPRR3 -0.3 -8.09 -0.3 2.91e-15 Inflammatory skin disease; BRCA cis rs250677 0.522 rs4705302 chr5:148354962 G/C cg12140854 chr5:148520817 ABLIM3 0.41 8.47 0.32 1.7e-16 Breast cancer; BRCA cis rs2171564 0.537 rs9815847 chr3:112439054 G/A cg06685282 chr3:112453648 NA 0.54 12.41 0.44 8.04e-32 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg20203395 chr5:56204925 C5orf35 0.36 7.88 0.3 1.46e-14 Type 2 diabetes; BRCA cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg05234568 chr11:5960015 NA -0.51 -10.15 -0.37 1.55e-22 DNA methylation (variation); BRCA cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -9.51 -0.35 3.7e-20 Aortic root size; BRCA trans rs2204008 0.754 rs11181643 chr12:38380553 G/A cg06521331 chr12:34319734 NA -0.45 -8.32 -0.31 5.14e-16 Bladder cancer; BRCA cis rs250677 0.522 rs3763022 chr5:148381078 A/G cg18129178 chr5:148520854 ABLIM3 -0.52 -10.4 -0.38 1.58e-23 Breast cancer; BRCA trans rs2204008 0.837 rs11168334 chr12:37961768 A/G cg06521331 chr12:34319734 NA -0.53 -9.6 -0.36 1.81e-20 Bladder cancer; BRCA cis rs1008375 0.931 rs6449310 chr4:17575530 T/C cg04450456 chr4:17643702 FAM184B 0.41 12.12 0.43 1.46e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs16866061 1.000 rs72974219 chr2:225423784 G/C cg12698349 chr2:225449008 CUL3 0.78 21.13 0.64 1.39e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.33 -10.91 -0.4 1.51e-25 Autism spectrum disorder or schizophrenia; BRCA trans rs853679 0.882 rs9468300 chr6:28126840 C/T cg01620082 chr3:125678407 NA -0.56 -7.96 -0.3 7.74e-15 Depression; BRCA cis rs11051970 0.879 rs2088807 chr12:32592101 C/G cg02745156 chr12:32552066 NA 0.27 8.85 0.33 8.74e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11711311 1.000 rs9826808 chr3:113455644 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 1.000 rs250677 chr5:148433549 T/C cg18129178 chr5:148520854 ABLIM3 -0.57 -11.68 -0.42 1.01e-28 Breast cancer; BRCA trans rs877282 1.000 rs12763443 chr10:771941 G/A cg22713356 chr15:30763199 NA 1.35 27.49 0.74 2.08e-110 Uric acid levels; BRCA cis rs4900538 0.927 rs1190544 chr14:102903398 G/A cg18135206 chr14:102964638 TECPR2 -1.06 -29.85 -0.76 3.05e-123 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.81 0.36 2.99e-21 Morning vs. evening chronotype; BRCA cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg19318889 chr4:1322082 MAEA 0.34 8.05 0.3 4.1e-15 Longevity; BRCA cis rs1538970 0.924 rs11211111 chr1:45908782 C/T cg05343316 chr1:45956843 TESK2 0.62 12.54 0.44 2.15e-32 Platelet count; BRCA cis rs2180341 0.781 rs6913350 chr6:127570560 C/T cg27446573 chr6:127587934 RNF146 0.69 15.09 0.51 3.27e-44 Breast cancer; BRCA cis rs4642101 0.765 rs9872103 chr3:12827452 G/T cg05775895 chr3:12838266 CAND2 0.35 7.84 0.3 1.84e-14 QRS complex (12-leadsum); BRCA cis rs6866344 0.570 rs1071882 chr5:178136040 C/T cg10224037 chr5:178157518 ZNF354A 0.79 18.04 0.58 4.01e-59 Neutrophil percentage of white cells; BRCA cis rs3733585 0.726 rs4306953 chr4:9955776 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.68e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10876993 0.890 rs799575 chr12:58069107 A/G cg18357645 chr12:58087776 OS9 0.48 13.8 0.48 4.19e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg26384229 chr12:38710491 ALG10B 0.75 16.93 0.56 2.16e-53 Bladder cancer; BRCA cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg24675658 chr1:53192096 ZYG11B 0.83 18.84 0.6 2.53e-63 Monocyte count; BRCA cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.37 0.38 2.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6894249 0.874 rs11745587 chr5:131796922 A/G cg02551604 chr5:131831745 NA 0.24 8.61 0.32 5.57e-17 Asthma; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg13397359 chr6:42928475 GNMT 0.68 16.24 0.54 6.67e-50 Plasma homocysteine levels (post-methionine load test); BRCA cis rs514406 0.505 rs405208 chr1:53176674 C/T cg16325326 chr1:53192061 ZYG11B 0.9 24.98 0.7 1.36e-96 Monocyte count; BRCA cis rs7833986 0.501 rs2976036 chr8:57031721 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.69 12.88 0.45 6.83e-34 Height; BRCA cis rs1371614 0.566 rs11695406 chr2:27178129 A/G cg00617064 chr2:27272375 NA 0.3 7.86 0.3 1.67e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6121246 0.821 rs6119718 chr20:30331074 A/G cg21427119 chr20:30132790 HM13 -0.41 -8.78 -0.33 1.53e-17 Mean corpuscular hemoglobin; BRCA cis rs6752107 0.935 rs11690131 chr2:234148383 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 10.65 0.39 1.74e-24 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg12311346 chr5:56204834 C5orf35 -0.8 -15.65 -0.53 5.83e-47 Initial pursuit acceleration; BRCA cis rs4148883 0.689 rs2851275 chr4:100024883 A/G cg12011299 chr4:100065546 ADH4 0.41 11.04 0.4 4.6e-26 Alcohol dependence; BRCA cis rs10189230 0.967 rs13012331 chr2:222350600 G/A cg14652038 chr2:222343519 EPHA4 0.48 13.26 0.46 1.28e-35 Urate levels in lean individuals; BRCA cis rs9393692 0.627 rs2179517 chr6:26198845 G/C cg00631329 chr6:26305371 NA -0.34 -9.73 -0.36 5.83e-21 Educational attainment; BRCA cis rs7131987 0.621 rs3782506 chr12:29445422 A/C cg09582351 chr12:29534625 ERGIC2 0.46 10.97 0.4 9.15e-26 QT interval; BRCA cis rs4268898 0.636 rs72787385 chr2:24585820 G/A cg08917208 chr2:24149416 ATAD2B 0.52 8.2 0.31 1.3e-15 Asthma; BRCA cis rs1215050 0.740 rs783945 chr4:99014394 G/A cg05340658 chr4:99064831 C4orf37 -0.48 -11.14 -0.4 1.9e-26 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 8.39 0.32 3.06e-16 Personality dimensions; BRCA trans rs6951245 1.000 rs113146460 chr7:1105164 C/G cg13565492 chr6:43139072 SRF -0.84 -11.44 -0.41 1.02e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs60843830 1.000 rs56167434 chr2:282137 G/C cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.45 0.5 3.6700000000000003e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs78707713 0.841 rs7475662 chr10:71210744 G/C cg12610070 chr10:71211762 TSPAN15 -0.32 -8.18 -0.31 1.54e-15 Venous thromboembolism; BRCA trans rs4714291 0.963 rs847759 chr6:40024483 G/A cg02267698 chr19:7991119 CTXN1 0.42 8.08 0.3 3.26e-15 Strep throat; BRCA cis rs17092148 0.887 rs6058104 chr20:33271052 G/A cg16810054 chr20:33298113 TP53INP2 -0.5 -10.66 -0.39 1.5e-24 Neuroticism; BRCA cis rs10411936 0.712 rs8103486 chr19:16603107 A/G cg10248733 chr19:16607483 C19orf44;CALR3 0.46 9.44 0.35 6.69e-20 White blood cell count;Multiple sclerosis; BRCA cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg08000102 chr2:233561755 GIGYF2 -0.46 -9.97 -0.37 7.41e-22 Coronary artery disease; BRCA cis rs16976116 0.901 rs28630909 chr15:55500102 G/A cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs11942114 chr4:99066261 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.6 0.39 2.78e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.800 rs4819045 chr21:46660138 C/A cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs10470245 chr21:46658912 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 13.92 0.48 1.2e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11690256 0.798 rs11678720 chr2:129542628 C/T cg16353174 chr2:129543148 NA -0.39 -7.98 -0.3 6.85e-15 Symmetrical dimethylarginine levels; BRCA cis rs1862618 0.853 rs33325 chr5:56142547 G/C cg18230493 chr5:56204884 C5orf35 -0.73 -14.78 -0.5 9.97e-43 Initial pursuit acceleration; BRCA cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg00074818 chr8:8560427 CLDN23 0.36 7.85 0.3 1.78e-14 Obesity-related traits; BRCA cis rs12354486 1 rs12354486 chr10:104124055 C/G cg15320455 chr10:103880129 LDB1 0.5 8.03 0.3 4.73e-15 Educational attainment (college completion); BRCA cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg26248373 chr2:1572462 NA -0.47 -9.18 -0.34 5.84e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg08822215 chr16:89438651 ANKRD11 0.53 11.95 0.43 7.36e-30 Multiple myeloma (IgH translocation); BRCA cis rs2016266 0.855 rs4759086 chr12:53666713 A/G cg26875137 chr12:53738046 NA 0.37 9.38 0.35 1.15e-19 Bone mineral density (spine);Bone mineral density; BRCA cis rs6893300 0.785 rs6887507 chr5:179186237 A/G cg14593053 chr5:179126677 CANX -0.35 -7.84 -0.3 1.92e-14 Resting heart rate; BRCA cis rs6121246 0.909 rs6119720 chr20:30347568 T/G cg21427119 chr20:30132790 HM13 -0.41 -8.75 -0.33 1.93e-17 Mean corpuscular hemoglobin; BRCA cis rs875971 0.825 rs1129531 chr7:65619104 C/T cg11764359 chr7:65958608 NA -0.76 -17.54 -0.57 1.61e-56 Aortic root size; BRCA cis rs12579753 0.879 rs7958657 chr12:82135067 G/A cg07988820 chr12:82153109 PPFIA2 -0.67 -11.4 -0.41 1.52e-27 Resting heart rate; BRCA cis rs3617 0.573 rs2336667 chr3:52916363 C/T cg11645453 chr3:52864694 ITIH4 -0.37 -9.67 -0.36 9.43e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs17253792 0.822 rs79618862 chr14:56093971 C/T cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg01579765 chr21:45077557 HSF2BP -0.42 -10.7 -0.39 1.12e-24 Mean corpuscular volume; BRCA cis rs4332037 0.522 rs4721098 chr7:1881527 G/C cg12432903 chr7:1882776 MAD1L1 -0.44 -7.87 -0.3 1.47e-14 Bipolar disorder; BRCA cis rs3733585 0.781 rs6449183 chr4:9970691 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -12.16 -0.43 9.59e-31 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1577917 0.958 rs16876530 chr6:86595641 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -10.97 -0.4 9.25e-26 Response to antipsychotic treatment; BRCA cis rs736408 0.609 rs62255396 chr3:52782839 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -12.81 -0.45 1.32e-33 Bipolar disorder; BRCA cis rs2832191 0.791 rs2832182 chr21:30481612 G/A cg24692254 chr21:30365293 RNF160 -0.66 -17.9 -0.58 2.24e-58 Dental caries; BRCA trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg13010199 chr12:38710504 ALG10B 0.49 9.56 0.35 2.42e-20 Morning vs. evening chronotype; BRCA cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg08213375 chr14:104286397 PPP1R13B 0.64 18.27 0.59 2.57e-60 Schizophrenia; BRCA cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg01444801 chr10:135216882 MTG1 -0.5 -11.03 -0.4 5.2e-26 Systemic lupus erythematosus; BRCA cis rs7312933 0.528 rs10880238 chr12:42489613 A/G cg01256987 chr12:42539512 GXYLT1 -0.68 -16.52 -0.55 2.71e-51 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7208859 0.673 rs11658435 chr17:29228561 A/G cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs11608355 0.545 rs11613021 chr12:109897998 T/G cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg03433033 chr1:76189801 ACADM 0.66 14.04 0.49 3.19e-39 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg15704280 chr7:45808275 SEPT13 0.74 15.67 0.53 4.33e-47 Coronary artery disease; BRCA cis rs4595586 0.545 rs61939643 chr12:39378460 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.35 0.35 1.48e-19 Morning vs. evening chronotype; BRCA trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg25482853 chr8:67687455 SGK3 1.05 17.55 0.57 1.44e-56 Lung disease severity in cystic fibrosis; BRCA cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.84 -0.3 1.83e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 0.932 rs417130 chr20:25458320 T/C cg08601574 chr20:25228251 PYGB 0.33 8.2 0.31 1.3e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs7678250 chr4:98922109 G/A cg17366294 chr4:99064904 C4orf37 0.43 10.28 0.38 4.81e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 29.89 0.76 1.85e-123 Chronic sinus infection; BRCA trans rs2204008 0.628 rs10876106 chr12:37990767 A/G cg06521331 chr12:34319734 NA -0.54 -10.34 -0.38 2.7e-23 Bladder cancer; BRCA cis rs4900538 0.855 rs762105 chr14:102830175 A/G cg18135206 chr14:102964638 TECPR2 -0.93 -21.79 -0.65 3.76e-79 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2070488 0.804 rs7372452 chr3:38444298 C/G cg24069376 chr3:38537580 EXOG 0.33 9.19 0.34 5.34e-19 Electrocardiographic conduction measures; BRCA cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg23055938 chr1:160991191 F11R -0.48 -9.46 -0.35 5.58e-20 Granulocyte percentage of myeloid white cells; BRCA cis rs4713118 0.513 rs149975 chr6:27986340 G/A cg10876282 chr6:28092338 ZSCAN16 0.41 8.0 0.3 5.69e-15 Parkinson's disease; BRCA cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12756686 chr19:29218302 NA 0.57 10.9 0.4 1.77e-25 Methadone dose in opioid dependence; BRCA cis rs6121246 0.909 rs6087778 chr20:30354142 G/A cg13852791 chr20:30311386 BCL2L1 0.84 16.63 0.55 7.51e-52 Mean corpuscular hemoglobin; BRCA cis rs12477438 0.798 rs6704766 chr2:99642818 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.67 0.42 1.18e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg12373951 chr3:133503437 NA 0.45 10.3 0.38 3.96e-23 Iron status biomarkers; BRCA cis rs4481887 0.893 rs4423045 chr1:248479495 T/C cg00666640 chr1:248458726 OR2T12 0.29 8.08 0.3 3.13e-15 Common traits (Other); BRCA cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg18765753 chr7:1198926 ZFAND2A -0.51 -11.82 -0.42 2.8e-29 Longevity;Endometriosis; BRCA cis rs9487051 0.768 rs9480910 chr6:109521707 T/C cg21918786 chr6:109611834 NA -0.35 -9.24 -0.34 3.73e-19 Reticulocyte fraction of red cells; BRCA cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg17509989 chr5:176798049 RGS14 0.63 12.59 0.45 1.22e-32 Hemoglobin concentration;Hematocrit; BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg22920501 chr2:26401640 FAM59B -0.79 -14.85 -0.51 4.6e-43 Gut microbiome composition (summer); BRCA cis rs11792861 0.926 rs72607171 chr9:111837776 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.2 0.31 1.28e-15 Menarche (age at onset); BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg04944784 chr2:26401820 FAM59B 0.82 11.21 0.41 9.44e-27 Gut microbiome composition (summer); BRCA cis rs9733 0.596 rs7529998 chr1:150662531 C/T cg17724175 chr1:150552817 MCL1 0.25 8.22 0.31 1.17e-15 Tonsillectomy; BRCA cis rs754466 0.580 rs2579178 chr10:79529215 A/G cg17075019 chr10:79541650 NA 0.79 19.16 0.6 5.51e-65 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg05234568 chr11:5960015 NA -0.49 -9.69 -0.36 7.99e-21 DNA methylation (variation); BRCA cis rs7772486 0.790 rs4314514 chr6:146260010 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -7.85 -0.3 1.74e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.591 rs162366 chr21:44935383 C/T cg01579765 chr21:45077557 HSF2BP 0.38 10.14 0.37 1.6e-22 Mean corpuscular volume; BRCA cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs13191362 0.507 rs13212746 chr6:163203092 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.52 9.91 0.36 1.25e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg04727924 chr7:799746 HEATR2 -0.54 -9.82 -0.36 2.62e-21 Cerebrospinal P-tau181p levels; BRCA cis rs4595586 0.545 rs12827823 chr12:39392144 G/T cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs9814567 0.806 rs7626557 chr3:134318213 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1707322 1.000 rs10890350 chr1:46262378 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.89e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg23992470 chr4:843637 GAK 0.55 8.19 0.31 1.42e-15 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg04025307 chr7:1156635 C7orf50 0.77 20.22 0.62 1.22e-70 Longevity;Endometriosis; BRCA trans rs2204008 0.807 rs8186948 chr12:38325101 C/G cg06521331 chr12:34319734 NA -0.45 -8.44 -0.32 2.06e-16 Bladder cancer; BRCA cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs782590 0.967 rs1975487 chr2:55809054 A/G cg18811423 chr2:55921094 PNPT1 0.7 22.16 0.66 3.94e-81 Metabolic syndrome; BRCA cis rs2882667 0.931 rs12719518 chr5:138340976 T/C cg04439458 chr5:138467593 SIL1 -0.33 -9.03 -0.34 2.08e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg03526776 chr6:41159608 TREML2 0.39 8.31 0.31 5.79e-16 Alzheimer's disease (late onset); BRCA cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg16145915 chr7:1198662 ZFAND2A -0.42 -8.1 -0.31 2.8e-15 Bronchopulmonary dysplasia; BRCA cis rs2832191 0.671 rs2832212 chr21:30511417 G/A cg08807101 chr21:30365312 RNF160 -0.44 -9.33 -0.35 1.66e-19 Dental caries; BRCA cis rs3761847 0.500 rs10760132 chr9:123739993 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.41 8.56 0.32 8.35e-17 Rheumatoid arthritis; BRCA cis rs7493 1.000 rs7493 chr7:95034775 C/G cg04155289 chr7:94953770 PON1 0.4 7.82 0.3 2.2e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs701145 0.556 rs355763 chr3:154012881 C/T cg12800244 chr3:153838788 SGEF 0.44 8.97 0.33 3.33e-18 Coronary artery disease; BRCA cis rs9324022 0.929 rs9635184 chr14:101173056 C/T cg18089426 chr14:101175970 NA 0.68 12.91 0.45 4.54e-34 Plateletcrit; BRCA cis rs2204008 0.683 rs12370288 chr12:38127740 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.91 0.37 1.2e-21 Bladder cancer; BRCA cis rs208520 1.000 rs208529 chr6:66957549 T/C cg07460842 chr6:66804631 NA -0.79 -13.3 -0.47 8.34e-36 Exhaled nitric oxide output; BRCA cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg24812749 chr6:127587940 RNF146 0.89 20.97 0.64 1.08e-74 Breast cancer; BRCA cis rs7917772 0.582 rs10883738 chr10:104321721 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.31 0.49 1.63e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6088580 0.524 rs6088567 chr20:33263872 A/T cg07148914 chr20:33460835 GGT7 -0.37 -7.99 -0.3 6.25e-15 Glomerular filtration rate (creatinine); BRCA cis rs2882667 0.628 rs3749663 chr5:138271187 A/T cg04439458 chr5:138467593 SIL1 -0.32 -8.04 -0.3 4.26e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6582630 0.519 rs12368889 chr12:38315160 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.69e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg10802521 chr3:52805072 NEK4 -0.33 -8.49 -0.32 1.45e-16 Bipolar disorder; BRCA cis rs7662987 0.517 rs1154405 chr4:100008750 G/A cg12011299 chr4:100065546 ADH4 0.48 10.94 0.4 1.22e-25 Smoking initiation; BRCA cis rs9309711 0.698 rs9750503 chr2:3491772 A/G cg16153549 chr2:3496821 NA 0.44 10.05 0.37 3.6e-22 Neurofibrillary tangles; BRCA cis rs10857712 0.687 rs11101742 chr10:135224372 C/G cg00491522 chr10:135256596 NA 0.44 9.24 0.34 3.66e-19 Systemic lupus erythematosus; BRCA cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg01181863 chr3:195395398 SDHAP2 -0.46 -8.2 -0.31 1.36e-15 Pancreatic cancer; BRCA trans rs11165623 0.564 rs6669908 chr1:96998261 G/A cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.11e-30 Hip circumference;Waist circumference; BRCA cis rs11098499 0.909 rs9994810 chr4:120381590 A/G cg09307838 chr4:120376055 NA 0.76 17.1 0.56 2.9e-54 Corneal astigmatism; BRCA cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.92 -0.3 1.08e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg08888203 chr3:10149979 C3orf24 0.58 11.86 0.42 1.8e-29 Alzheimer's disease; BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg12016809 chr21:47604291 C21orf56 0.4 8.38 0.31 3.37e-16 Testicular germ cell tumor; BRCA cis rs9469578 1.000 rs6923565 chr6:33707112 G/A cg18708504 chr6:33715942 IP6K3 0.72 10.42 0.38 1.43e-23 Phosphorus levels; BRCA cis rs8062405 0.823 rs7202948 chr16:28558289 T/A cg16576597 chr16:28551801 NUPR1 0.28 7.98 0.3 6.98e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.73 0.36 5.76e-21 Bipolar disorder; BRCA cis rs7666738 0.830 rs17550610 chr4:99008273 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.54 0.57 1.68e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2336384 1.000 rs2878677 chr1:12053264 C/T cg13216073 chr1:12042593 MFN2 -0.41 -9.15 -0.34 7.58e-19 Platelet count; BRCA cis rs250677 0.652 rs250670 chr5:148446646 G/T cg12140854 chr5:148520817 ABLIM3 -0.42 -8.69 -0.33 3.04e-17 Breast cancer; BRCA cis rs7772486 0.875 rs2814876 chr6:146304030 C/T cg23711669 chr6:146136114 FBXO30 0.74 16.73 0.55 2.23e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg22920501 chr2:26401640 FAM59B -0.67 -11.5 -0.41 5.96e-28 Gut microbiome composition (summer); BRCA cis rs17092148 1.000 rs910872 chr20:33334540 T/C cg16810054 chr20:33298113 TP53INP2 -0.5 -11.31 -0.41 3.74e-27 Neuroticism; BRCA cis rs3768617 0.510 rs10911239 chr1:183062450 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 18.03 0.58 4.79e-59 Fuchs's corneal dystrophy; BRCA trans rs6951245 1.000 rs74366004 chr7:1088630 A/C cg13565492 chr6:43139072 SRF -0.79 -10.84 -0.39 2.99e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg03929089 chr4:120376271 NA 0.71 14.75 0.5 1.37e-42 Coronary artery disease; BRCA cis rs6920965 0.507 rs9385388 chr6:126215296 C/T cg05901451 chr6:126070800 HEY2 -0.51 -12.57 -0.45 1.62e-32 High light scatter reticulocyte count; BRCA cis rs4242434 0.757 rs2280104 chr8:22525980 C/T cg03733263 chr8:22462867 KIAA1967 0.88 18.96 0.6 6.32e-64 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.85 -0.3 1.8e-14 Colorectal cancer; BRCA cis rs490234 1.000 rs490234 chr9:128303734 T/C cg14078157 chr9:128172775 NA 0.33 7.89 0.3 1.3e-14 Mean arterial pressure; BRCA cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.51 9.48 0.35 4.78e-20 Aortic root size; BRCA cis rs858239 0.600 rs2072368 chr7:23146112 C/T cg23682824 chr7:23144976 KLHL7 0.42 11.18 0.4 1.22e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs1862618 0.853 rs10051747 chr5:56083289 C/A cg18230493 chr5:56204884 C5orf35 -0.74 -14.04 -0.49 3.24e-39 Initial pursuit acceleration; BRCA cis rs514406 0.644 rs7529978 chr1:53204705 G/A cg16325326 chr1:53192061 ZYG11B -0.71 -18.64 -0.59 3.1e-62 Monocyte count; BRCA cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg20701182 chr2:24300061 SF3B14 -0.71 -13.09 -0.46 7.06e-35 Lymphocyte counts; BRCA cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.51 11.56 0.42 3.29e-28 Bipolar disorder; BRCA cis rs9811920 0.732 rs793446 chr3:99578114 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.54 -13.17 -0.46 3.37e-35 Axial length; BRCA trans rs7980799 0.711 rs12319055 chr12:33626509 C/T cg26384229 chr12:38710491 ALG10B -0.48 -10.39 -0.38 1.86e-23 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg25036284 chr2:26402008 FAM59B 0.9 14.79 0.5 9.2e-43 Gut microbiome composition (summer); BRCA cis rs273218 0.951 rs428213 chr5:53382790 T/G ch.5.1024479R chr5:53302184 ARL15 -0.39 -8.2 -0.31 1.34e-15 Migraine; BRCA cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7098414 0.511 rs10749592 chr10:82150891 C/T cg01528321 chr10:82214614 TSPAN14 0.65 14.07 0.49 2.21e-39 Post bronchodilator FEV1; BRCA cis rs7246657 0.823 rs4802236 chr19:37919246 A/G cg18154014 chr19:37997991 ZNF793 0.62 11.59 0.42 2.63e-28 Coronary artery calcification; BRCA cis rs57590327 0.508 rs13093082 chr3:81949958 C/T cg07356753 chr3:81810745 GBE1 -0.36 -8.46 -0.32 1.8e-16 Extraversion; BRCA cis rs782590 0.807 rs782642 chr2:55928444 G/T cg18811423 chr2:55921094 PNPT1 0.79 27.76 0.74 7.39e-112 Metabolic syndrome; BRCA cis rs2797160 0.714 rs1777220 chr6:126022602 G/T cg05901451 chr6:126070800 HEY2 0.42 10.04 0.37 4.01e-22 Endometrial cancer; BRCA cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg08885076 chr2:99613938 TSGA10 -0.53 -9.59 -0.35 1.95e-20 Chronic sinus infection; BRCA cis rs9393692 0.905 rs7761298 chr6:26278436 C/T cg05868516 chr6:26286170 HIST1H4H 0.5 11.25 0.41 6.6e-27 Educational attainment; BRCA cis rs10876993 0.890 rs812304 chr12:58074853 A/C cg18357645 chr12:58087776 OS9 0.47 13.47 0.47 1.45e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs7903847 0.642 rs61863819 chr10:99142400 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.01 -0.3 5.35e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs6582630 0.555 rs10880607 chr12:38508184 A/G cg26384229 chr12:38710491 ALG10B 0.77 17.67 0.57 3.37e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs7772486 0.817 rs12198065 chr6:146385286 G/C cg13319975 chr6:146136371 FBXO30 -0.39 -8.9 -0.33 5.92e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs4919694 1.000 rs78214351 chr10:104822688 A/G cg04362960 chr10:104952993 NT5C2 0.94 14.59 0.5 8.2e-42 Arsenic metabolism; BRCA cis rs3093024 0.595 rs4412174 chr6:167476066 A/G cg07741184 chr6:167504864 NA 0.36 10.48 0.38 7.88e-24 Rheumatoid arthritis; BRCA cis rs7246657 0.941 rs12982333 chr19:37794724 A/G cg18154014 chr19:37997991 ZNF793 0.53 10.14 0.37 1.74e-22 Coronary artery calcification; BRCA cis rs7072216 0.770 rs1061115 chr10:100177049 G/A cg26618903 chr10:100175079 PYROXD2 -0.27 -8.19 -0.31 1.38e-15 Metabolite levels; BRCA cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg26384229 chr12:38710491 ALG10B 0.74 17.21 0.56 7.75e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg25817165 chr18:72167213 CNDP2 -0.73 -14.46 -0.5 3.2e-41 Refractive error; BRCA cis rs6570726 0.791 rs427128 chr6:145865917 T/C cg05347473 chr6:146136440 FBXO30 0.42 8.34 0.31 4.63e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6060717 0.536 rs11167279 chr20:34509107 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.1 -0.31 2.73e-15 Hip circumference adjusted for BMI; BRCA cis rs10501293 0.912 rs4755694 chr11:43088582 A/G cg03447554 chr11:43094025 NA -0.48 -8.95 -0.33 3.95e-18 Cognitive performance; BRCA trans rs75804782 0.521 rs56087929 chr2:239455564 G/A cg01134436 chr17:81009848 B3GNTL1 0.63 8.36 0.31 3.83e-16 Morning vs. evening chronotype;Chronotype; BRCA cis rs2762353 0.718 rs1165207 chr6:25865266 A/G cg12310025 chr6:25882481 NA -0.56 -14.03 -0.49 3.6e-39 Blood metabolite levels; BRCA cis rs7833790 0.685 rs13255262 chr8:82728024 T/G cg02079420 chr8:82753780 SNX16 0.31 8.38 0.31 3.42e-16 Diastolic blood pressure; BRCA cis rs7786808 0.712 rs2335170 chr7:158207101 G/A cg09998033 chr7:158218633 PTPRN2 -0.33 -7.81 -0.3 2.42e-14 Obesity-related traits; BRCA cis rs6594713 0.642 rs13169748 chr5:112848999 C/T cg12552261 chr5:112820674 MCC 0.49 7.81 0.3 2.34e-14 Brain cytoarchitecture; BRCA trans rs1005277 0.579 rs2472173 chr10:38374638 G/A cg23533926 chr12:111358616 MYL2 -0.41 -8.49 -0.32 1.4e-16 Extrinsic epigenetic age acceleration; BRCA cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg09184832 chr6:79620586 NA -0.52 -11.42 -0.41 1.3e-27 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11644478 chr21:40555479 PSMG1 0.84 19.14 0.6 6.9e-65 Cognitive function; BRCA cis rs698833 0.848 rs696596 chr2:44718058 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.46 9.29 0.35 2.35e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs1862618 0.620 rs2591967 chr5:56233551 C/G cg22800045 chr5:56110881 MAP3K1 -0.46 -9.11 -0.34 1.03e-18 Initial pursuit acceleration; BRCA cis rs10504229 1.000 rs17217082 chr8:58180918 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs12497850 0.931 rs6791542 chr3:48787219 A/G cg07636037 chr3:49044803 WDR6 0.95 27.61 0.74 4.77e-111 Parkinson's disease; BRCA cis rs2882667 0.690 rs6596453 chr5:138151891 T/G cg04439458 chr5:138467593 SIL1 0.35 8.47 0.32 1.63e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9814567 0.806 rs4519744 chr3:134321523 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs849141 0.857 rs1708299 chr7:28189946 A/G cg22892036 chr7:28189139 JAZF1 0.47 8.31 0.31 5.81e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs332507 0.830 rs3772781 chr3:124387439 G/T cg05980111 chr3:124395277 KALRN 0.37 8.58 0.32 7.31e-17 Plateletcrit; BRCA cis rs17270561 0.609 rs4145216 chr6:25743559 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs1008375 0.932 rs9283698 chr4:17662471 T/C cg02297831 chr4:17616191 MED28 0.36 7.88 0.3 1.43e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg23055938 chr1:160991191 F11R -0.55 -10.77 -0.39 5.5e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs7715811 1.000 rs10050673 chr5:13761643 G/A cg07548982 chr5:13769939 DNAH5 -0.38 -8.33 -0.31 4.98e-16 Subclinical atherosclerosis traits (other); BRCA cis rs10504073 0.584 rs115370638 chr8:49916452 A/G cg00325661 chr8:49890786 NA 0.52 15.26 0.52 4.62e-45 Blood metabolite ratios; BRCA cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.23 0.52 6.88e-45 Colorectal cancer; BRCA cis rs875971 0.564 rs313804 chr7:65514622 A/G cg18876405 chr7:65276391 NA 0.58 13.95 0.48 8.13e-39 Aortic root size; BRCA cis rs2346177 0.513 rs1530625 chr2:46658067 C/T cg02822958 chr2:46747628 ATP6V1E2 0.46 9.68 0.36 9.34e-21 HDL cholesterol; BRCA cis rs67460515 0.665 rs28384382 chr3:160939141 C/T cg17135325 chr3:160939158 NMD3 0.47 9.1 0.34 1.12e-18 Parkinson's disease; BRCA cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11890956 chr21:40555474 PSMG1 1.05 29.75 0.76 9.7e-123 Cognitive function; BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg12311346 chr5:56204834 C5orf35 -0.78 -15.9 -0.53 3.47e-48 Initial pursuit acceleration; BRCA cis rs7246657 0.722 rs4802029 chr19:38055612 A/T cg23950597 chr19:37808831 NA -0.5 -8.62 -0.32 5.36e-17 Coronary artery calcification; BRCA cis rs10927875 0.619 rs12121764 chr1:16138059 A/T cg21385522 chr1:16154831 NA -0.57 -13.26 -0.46 1.24e-35 Dilated cardiomyopathy; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg23358479 chr7:1110784 C7orf50 -0.47 -7.99 -0.3 6.1e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg21573476 chr21:45109991 RRP1B -0.44 -10.84 -0.39 3.01e-25 Mean corpuscular volume; BRCA cis rs11997175 0.603 rs66828270 chr8:33790155 C/G ch.8.33884649F chr8:33765107 NA 0.39 9.19 0.34 5.39e-19 Body mass index; BRCA cis rs6598955 0.671 rs12089149 chr1:26638500 C/A cg04990556 chr1:26633338 UBXN11 0.56 9.15 0.34 7.48e-19 Obesity-related traits; BRCA cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.62 13.82 0.48 3.53e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9790314 0.936 rs336572 chr3:161068014 G/A cg04691961 chr3:161091175 C3orf57 -0.5 -12.55 -0.44 1.92e-32 Morning vs. evening chronotype; BRCA cis rs1862618 0.853 rs832582 chr5:56177743 G/A cg24531977 chr5:56204891 C5orf35 -0.86 -17.48 -0.57 3.46e-56 Initial pursuit acceleration; BRCA cis rs12367572 0.930 rs11615964 chr12:45261564 C/T cg04608330 chr12:45269318 NELL2 -0.63 -13.33 -0.47 5.95e-36 Gut microbiome composition (summer); BRCA cis rs9400271 0.632 rs9386784 chr6:109591208 C/A cg01475377 chr6:109611718 NA -0.44 -10.4 -0.38 1.7e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs2842992 0.830 rs2758352 chr6:160122921 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.68 0.42 1.06e-28 Age-related macular degeneration (geographic atrophy); BRCA cis rs9287719 0.601 rs759401 chr2:10709922 G/A cg00105475 chr2:10696890 NA 0.47 10.33 0.38 3.19e-23 Prostate cancer; BRCA cis rs7092929 0.941 rs835325 chr10:3571175 A/G cg14308648 chr10:3568949 NA 0.44 8.12 0.31 2.44e-15 Coronary artery calcification; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.73 16.32 0.54 2.48e-50 Lymphocyte counts; BRCA cis rs9486715 0.867 rs9373887 chr6:96957004 C/T cg06623918 chr6:96969491 KIAA0776 0.89 25.59 0.71 5.41e-100 Headache; BRCA cis rs11971779 0.625 rs2355784 chr7:139072493 G/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs7851660 0.933 rs1867277 chr9:100615914 A/G cg13688889 chr9:100608707 NA -0.36 -8.72 -0.33 2.42e-17 Strep throat; BRCA cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg07952391 chr2:88470173 THNSL2 0.66 9.05 0.34 1.64e-18 Plasma clusterin levels; BRCA cis rs1003719 0.680 rs2835664 chr21:38573429 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs7618501 0.602 rs2301166 chr3:50148305 C/G cg05623727 chr3:50126028 RBM5 -0.43 -10.34 -0.38 2.76e-23 Intelligence (multi-trait analysis); BRCA cis rs67981189 0.788 rs2526860 chr14:71411878 T/C cg15816911 chr14:71606274 NA -0.37 -8.18 -0.31 1.52e-15 Schizophrenia; BRCA cis rs919433 0.679 rs67492914 chr2:198523402 T/G cg00792783 chr2:198669748 PLCL1 0.39 9.02 0.34 2.24e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs875971 0.862 rs11984115 chr7:65773859 C/T cg18876405 chr7:65276391 NA -0.49 -11.0 -0.4 6.6900000000000006e-26 Aortic root size; BRCA cis rs1801251 1.000 rs1801251 chr2:233633460 G/A cg25237894 chr2:233734115 C2orf82 0.39 11.36 0.41 2.26e-27 Coronary artery disease; BRCA cis rs2404602 1.000 rs2120107 chr15:76869789 A/G cg26408565 chr15:76604113 ETFA -0.36 -8.0 -0.3 5.91e-15 Blood metabolite levels; BRCA cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.15 0.31 1.86e-15 Cardiac Troponin-T levels; BRCA trans rs7746199 0.736 rs17693963 chr6:27710165 A/C cg06606381 chr12:133084897 FBRSL1 -0.76 -8.34 -0.31 4.6e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA trans rs11098499 0.691 rs28396837 chr4:120271541 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.64 0.39 1.93e-24 Corneal astigmatism; BRCA cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg24642439 chr20:33292090 TP53INP2 0.71 16.27 0.54 4.9e-50 Coronary artery disease; BRCA trans rs61931739 0.963 rs12310956 chr12:33970682 A/G cg26384229 chr12:38710491 ALG10B -0.4 -8.85 -0.33 8.87e-18 Morning vs. evening chronotype; BRCA cis rs1707322 0.721 rs7520123 chr1:46235219 C/G cg06784218 chr1:46089804 CCDC17 0.47 11.39 0.41 1.69e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1008375 1.000 rs10939756 chr4:17693867 C/T cg04450456 chr4:17643702 FAM184B 0.32 9.33 0.35 1.7e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10883723 0.810 rs7092622 chr10:104249919 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 19.18 0.6 4.26e-65 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6456156 0.586 rs12528689 chr6:167461746 A/G cg07741184 chr6:167504864 NA 0.33 9.8 0.36 3.32e-21 Primary biliary cholangitis; BRCA cis rs10463316 0.894 rs7723379 chr5:150765025 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.37 -0.31 3.51e-16 Metabolite levels (Pyroglutamine); BRCA trans rs8073060 0.586 rs225300 chr17:33922428 C/T cg19694781 chr19:47549865 TMEM160 -1.01 -21.06 -0.64 3.73e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.93 0.33 4.64e-18 Tonsillectomy; BRCA cis rs1003719 0.762 rs1015551 chr21:38449510 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.29e-40 Eye color traits; BRCA cis rs9443645 0.901 rs9448596 chr6:79629429 T/C cg05283184 chr6:79620031 NA -0.41 -10.51 -0.38 6.1e-24 Intelligence (multi-trait analysis); BRCA cis rs7100689 0.646 rs1290317 chr10:82062531 C/A cg00277334 chr10:82204260 NA -0.42 -8.23 -0.31 1.04e-15 Post bronchodilator FEV1; BRCA trans rs8073060 0.586 rs7214250 chr17:33981704 C/G cg19694781 chr19:47549865 TMEM160 -1.04 -21.89 -0.65 1.12e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs6964587 1.000 rs11982213 chr7:91722966 A/G cg17063962 chr7:91808500 NA 0.52 12.33 0.44 1.69e-31 Breast cancer; BRCA cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg12564285 chr5:131593104 PDLIM4 0.36 8.06 0.3 3.75e-15 Breast cancer; BRCA cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.84 -0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6570726 0.791 rs408443 chr6:145874643 T/C cg05347473 chr6:146136440 FBXO30 0.43 8.55 0.32 8.98e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1003719 0.680 rs2835629 chr21:38521660 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.43 -0.5 4.76e-41 Eye color traits; BRCA cis rs7572733 0.534 rs700672 chr2:198691455 G/A cg00792783 chr2:198669748 PLCL1 0.47 10.2 0.37 1.01e-22 Dermatomyositis; BRCA cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg12311346 chr5:56204834 C5orf35 -0.81 -16.16 -0.54 1.65e-49 Initial pursuit acceleration; BRCA cis rs10504229 0.683 rs903706 chr8:58128134 T/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg11890956 chr21:40555474 PSMG1 -0.6 -13.36 -0.47 4.47e-36 Menarche (age at onset); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg04025307 chr7:1156635 C7orf50 0.56 13.27 0.46 1.17e-35 Longevity;Endometriosis; BRCA cis rs11229555 0.645 rs12786744 chr11:58177549 T/C cg15696309 chr11:58395628 NA -0.52 -10.78 -0.39 5.3e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg17691542 chr6:26056736 HIST1H1C 0.5 10.55 0.39 4.14e-24 Height; BRCA cis rs2882667 1.000 rs2882667 chr5:138314106 C/T cg04439458 chr5:138467593 SIL1 -0.39 -10.32 -0.38 3.33e-23 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11890956 chr21:40555474 PSMG1 1.03 27.91 0.74 1.1e-112 Cognitive function; BRCA trans rs11098499 0.754 rs9991959 chr4:120253773 C/T cg25214090 chr10:38739885 LOC399744 -0.44 -10.17 -0.37 1.31e-22 Corneal astigmatism; BRCA cis rs9914988 0.943 rs9890155 chr17:27125467 A/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg12310025 chr6:25882481 NA -0.42 -10.26 -0.38 5.99e-23 Height; BRCA cis rs514406 0.505 rs431459 chr1:53183230 T/G cg16325326 chr1:53192061 ZYG11B 0.91 25.09 0.7 3.34e-97 Monocyte count; BRCA cis rs7246657 1.000 rs6508710 chr19:37749886 A/G cg14683738 chr19:37701593 ZNF585B 0.48 8.3 0.31 6.07e-16 Coronary artery calcification; BRCA cis rs56104184 0.830 rs17206679 chr19:49342237 C/G cg15549821 chr19:49342101 PLEKHA4 -1.06 -16.65 -0.55 5.51e-52 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs35849525 0.776 rs7615318 chr3:49987475 C/T cg14019146 chr3:50243930 SLC38A3 -0.56 -11.77 -0.42 4.4e-29 Intelligence (multi-trait analysis); BRCA cis rs7647973 1.000 rs3905330 chr3:49550774 A/G cg07636037 chr3:49044803 WDR6 0.73 15.85 0.53 5.73e-48 Menarche (age at onset); BRCA cis rs7833790 0.724 rs6473310 chr8:82707981 A/G cg27398817 chr8:82754497 SNX16 -0.36 -8.17 -0.31 1.68e-15 Diastolic blood pressure; BRCA cis rs6964587 1.000 rs926192 chr7:91671853 C/A cg17063962 chr7:91808500 NA 0.58 13.72 0.48 9.56e-38 Breast cancer; BRCA cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg07700843 chr1:2391317 NA -0.5 -11.59 -0.42 2.42e-28 Schizophrenia; BRCA cis rs10464366 0.957 rs2392618 chr7:39108392 G/A cg15212455 chr7:39170539 POU6F2 0.36 7.85 0.3 1.8e-14 IgG glycosylation; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg26119090 chr2:26468346 HADHA;HADHB 0.75 11.82 0.42 2.63e-29 Gut microbiome composition (summer); BRCA cis rs877282 1.000 rs12779159 chr10:772143 T/C cg17470449 chr10:769945 NA 0.5 8.91 0.33 5.45e-18 Uric acid levels; BRCA cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg08885076 chr2:99613938 TSGA10 -0.59 -13.17 -0.46 3.23e-35 Chronic sinus infection; BRCA cis rs7617773 0.778 rs11715776 chr3:48377611 G/C cg11946769 chr3:48343235 NME6 0.67 13.46 0.47 1.62e-36 Coronary artery disease; BRCA cis rs11252926 0.599 rs11252213 chr10:454694 C/T cg18196295 chr10:418757 DIP2C 0.49 11.84 0.42 2.21e-29 Psychosis in Alzheimer's disease; BRCA cis rs2075371 0.863 rs1646638 chr7:134008706 T/C cg02659138 chr7:134003124 SLC35B4 0.37 11.63 0.42 1.73e-28 Mean platelet volume; BRCA cis rs41005 1.000 rs193932 chr2:8107383 C/T cg03155496 chr2:8117019 LOC339788 -0.55 -14.66 -0.5 3.81e-42 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs13046373 0.535 rs7281767 chr21:32022062 T/C cg14062083 chr21:31802829 KRTAP13-4 0.34 9.46 0.35 5.95e-20 HDL cholesterol; BRCA cis rs61931739 0.500 rs6488213 chr12:34393319 C/T cg06521331 chr12:34319734 NA -0.51 -10.12 -0.37 1.98e-22 Morning vs. evening chronotype; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg00802000 chr16:706648 WDR90 -0.4 -9.4 -0.35 9.77e-20 Height; BRCA cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg24675658 chr1:53192096 ZYG11B 0.55 12.59 0.45 1.31e-32 Monocyte count; BRCA cis rs11051970 0.918 rs325417 chr12:32574217 A/G cg02745156 chr12:32552066 NA 0.28 9.01 0.34 2.4e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.72 11.84 0.42 2.3e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4671400 0.543 rs2290324 chr2:61448776 A/C cg15711740 chr2:61764176 XPO1 0.44 8.79 0.33 1.41e-17 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs700651 0.789 rs116165148 chr2:198888347 T/G cg00792783 chr2:198669748 PLCL1 0.38 8.74 0.33 2.06e-17 Intracranial aneurysm; BRCA trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21659725 chr3:3221576 CRBN -0.47 -11.88 -0.43 1.57e-29 Intelligence (multi-trait analysis); BRCA trans rs66887589 0.967 rs1480933 chr4:120433248 C/T cg25214090 chr10:38739885 LOC399744 0.36 8.1 0.31 2.72e-15 Diastolic blood pressure; BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg16606324 chr3:10149918 C3orf24 0.57 11.38 0.41 1.87e-27 Alzheimer's disease; BRCA cis rs9337951 0.596 rs3739998 chr10:30316072 C/G cg12786570 chr10:30316432 KIAA1462 0.37 7.89 0.3 1.29e-14 Pulse pressure;Coronary artery disease; BRCA cis rs1059312 0.808 rs2306683 chr12:129299675 C/G cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.77 -19.58 -0.61 3.29e-67 Systemic lupus erythematosus; BRCA cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg20607287 chr7:12443886 VWDE -0.58 -8.32 -0.31 5.31e-16 Coronary artery disease; BRCA cis rs9287719 0.967 rs6432118 chr2:10749441 C/T cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg05863683 chr7:1912471 MAD1L1 0.38 8.21 0.31 1.22e-15 Schizophrenia; BRCA trans rs7726839 0.526 rs11960159 chr5:568685 C/T cg25482853 chr8:67687455 SGK3 0.75 13.43 0.47 2.05e-36 Obesity-related traits; BRCA cis rs3768617 0.811 rs6424883 chr1:183037695 T/C ch.1.3577855R chr1:183094577 LAMC1 0.46 9.94 0.37 9.49e-22 Fuchs's corneal dystrophy; BRCA cis rs11955398 0.585 rs2085409 chr5:60021183 C/T cg02684056 chr5:59996105 DEPDC1B -0.38 -9.13 -0.34 8.56e-19 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.633 rs4688758 chr3:50028385 G/A cg24110177 chr3:50126178 RBM5 -0.37 -9.81 -0.36 2.96e-21 Intelligence (multi-trait analysis); BRCA cis rs7824557 0.806 rs6601573 chr8:11094751 A/G cg21775007 chr8:11205619 TDH -0.47 -9.36 -0.35 1.32e-19 Retinal vascular caliber; BRCA cis rs870825 0.581 rs28602720 chr4:185630598 T/C cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.9e-54 Blood protein levels; BRCA cis rs1468333 0.897 rs2269957 chr5:137501396 A/C cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.99 0.34 2.77e-18 Resting heart rate; BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.88 -16.9 -0.56 3.03e-53 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg16606324 chr3:10149918 C3orf24 0.56 11.01 0.4 5.91e-26 Alzheimer's disease; BRCA cis rs1018836 1.000 rs1018836 chr8:91570362 A/G cg16814680 chr8:91681699 NA -0.57 -12.35 -0.44 1.47e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs910316 0.763 rs175490 chr14:75545685 A/G cg23033748 chr14:75592666 NEK9 0.36 8.42 0.32 2.47e-16 Height; BRCA trans rs9929218 0.507 rs62057805 chr16:68742390 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 29.23 0.76 6.58e-120 Colorectal cancer; BRCA trans rs9291683 0.588 rs3796842 chr4:9995851 A/T cg26043149 chr18:55253948 FECH 0.38 8.69 0.33 3.13e-17 Bone mineral density; BRCA cis rs12497850 0.797 rs61583136 chr3:49189195 C/T cg06212747 chr3:49208901 KLHDC8B 0.53 11.11 0.4 2.43e-26 Parkinson's disease; BRCA trans rs2562456 0.682 rs11085464 chr19:21751778 C/G cg25042112 chr7:64838748 ZNF92 -0.45 -8.42 -0.32 2.47e-16 Pain; BRCA trans rs6582630 0.537 rs12823925 chr12:38409323 C/T cg06521331 chr12:34319734 NA -0.48 -8.85 -0.33 8.59e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs4728302 0.869 rs7792905 chr7:133595602 G/T cg07491979 chr7:133331646 EXOC4 0.36 7.84 0.3 1.88e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg14061069 chr19:46274453 DMPK 0.66 18.91 0.6 1.11e-63 Coronary artery disease; BRCA trans rs9329221 0.527 rs4841351 chr8:10327367 G/A cg06636001 chr8:8085503 FLJ10661 -0.5 -10.36 -0.38 2.35e-23 Neuroticism; BRCA cis rs4819852 0.958 rs1034564 chr22:19984013 A/G cg07821417 chr22:19972146 ARVCF -0.46 -10.84 -0.39 2.87e-25 Pulse pressure; BRCA cis rs7147624 0.766 rs11158597 chr14:65913536 T/G cg03016385 chr14:66212404 NA -0.57 -8.81 -0.33 1.15e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg08280861 chr8:58055591 NA 0.53 8.62 0.32 5.17e-17 Developmental language disorder (linguistic errors); BRCA cis rs654351 0.543 rs622388 chr6:10387117 T/G cg04978078 chr6:10383147 NA -0.44 -8.61 -0.32 5.65e-17 Squamous cell lung carcinoma; BRCA cis rs4819052 0.959 rs8130866 chr21:46672112 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.61 11.01 0.4 6.16e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg18200150 chr17:30822561 MYO1D 0.35 8.81 0.33 1.19e-17 Schizophrenia; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg14004847 chr7:1930337 MAD1L1 -0.43 -8.14 -0.31 2.03e-15 Bipolar disorder and schizophrenia; BRCA cis rs2617583 0.967 rs2617594 chr5:1448288 A/G cg07151155 chr5:1473589 LPCAT1 -0.42 -9.0 -0.34 2.59e-18 Breast cancer; BRCA cis rs250677 0.522 rs12523526 chr5:148349107 A/C cg12140854 chr5:148520817 ABLIM3 0.42 8.43 0.32 2.27e-16 Breast cancer; BRCA cis rs6785206 0.892 rs2712429 chr3:128336221 A/C cg16766828 chr3:128327626 NA -0.8 -11.64 -0.42 1.54e-28 Lymphocyte percentage of white cells; BRCA cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg11890956 chr21:40555474 PSMG1 -0.82 -19.62 -0.61 1.92e-67 Cognitive function; BRCA cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg24110177 chr3:50126178 RBM5 0.53 15.95 0.53 1.85e-48 Body mass index; BRCA cis rs10465746 0.570 rs11163885 chr1:84472956 A/G cg10977910 chr1:84465055 TTLL7 0.54 11.08 0.4 3.22e-26 Obesity-related traits; BRCA cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg11764359 chr7:65958608 NA 0.62 13.46 0.47 1.5e-36 Aortic root size; BRCA cis rs7267979 0.966 rs2261795 chr20:25263136 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.61 0.36 1.57e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2576037 0.796 rs2247221 chr18:44580082 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -9.17 -0.34 6.25e-19 Personality dimensions; BRCA cis rs68170813 0.559 rs77185844 chr7:106812916 A/C cg02696742 chr7:106810147 HBP1 -0.54 -8.61 -0.32 5.6e-17 Coronary artery disease; BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg05896524 chr21:47604654 C21orf56 0.52 10.58 0.39 3.38e-24 Testicular germ cell tumor; BRCA cis rs769267 0.930 rs1047361 chr19:19606634 G/A cg03709012 chr19:19516395 GATAD2A 0.81 18.85 0.6 2.32e-63 Tonsillectomy; BRCA cis rs6088580 0.634 rs6058052 chr20:33047084 A/G cg08999081 chr20:33150536 PIGU 0.44 12.51 0.44 2.96e-32 Glomerular filtration rate (creatinine); BRCA cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg08999081 chr20:33150536 PIGU 0.35 9.06 0.34 1.52e-18 Coronary artery disease; BRCA cis rs924607 0.898 rs1697990 chr5:626278 A/G cg24163568 chr5:669837 TPPP -0.35 -9.46 -0.35 5.56e-20 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs1005277 0.579 rs176886 chr10:38403974 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.81e-26 Extrinsic epigenetic age acceleration; BRCA trans rs3749237 0.964 rs10865959 chr3:49891002 G/C cg21659725 chr3:3221576 CRBN 0.49 11.2 0.41 1.07e-26 Resting heart rate; BRCA cis rs7647973 0.593 rs55997059 chr3:49858661 A/T cg07636037 chr3:49044803 WDR6 -0.5 -8.49 -0.32 1.45e-16 Menarche (age at onset); BRCA cis rs4665809 0.759 rs62128394 chr2:26364026 T/G cg25036284 chr2:26402008 FAM59B 0.84 11.41 0.41 1.45e-27 Gut microbiome composition (summer); BRCA cis rs1005277 0.579 rs1780116 chr10:38526621 C/T cg25427524 chr10:38739819 LOC399744 -0.74 -18.27 -0.59 2.53e-60 Extrinsic epigenetic age acceleration; BRCA cis rs6860806 0.507 rs2631364 chr5:131706914 C/G cg24060327 chr5:131705240 SLC22A5 0.61 11.38 0.41 1.91e-27 Breast cancer; BRCA cis rs1448094 0.512 rs56082822 chr12:86255475 C/T cg19622623 chr12:86230825 RASSF9 -0.35 -9.78 -0.36 3.71e-21 Major depressive disorder; BRCA trans rs11098499 0.779 rs10857066 chr4:120286596 C/T cg25214090 chr10:38739885 LOC399744 0.49 11.41 0.41 1.48e-27 Corneal astigmatism; BRCA cis rs7647973 0.593 rs59684465 chr3:49874246 C/T cg03060546 chr3:49711283 APEH -0.59 -10.42 -0.38 1.39e-23 Menarche (age at onset); BRCA cis rs11723261 0.582 rs4582104 chr4:136942 A/T cg12746427 chr4:53362 ZNF718;ZNF595 0.34 8.37 0.31 3.77e-16 Immune response to smallpox vaccine (IL-6); BRCA cis rs11809207 0.523 rs2802343 chr1:26498570 T/C cg23602478 chr1:26503979 CNKSR1 0.23 8.03 0.3 4.83e-15 Height; BRCA cis rs9487051 0.837 rs4403290 chr6:109611583 A/T cg21918786 chr6:109611834 NA -0.49 -14.14 -0.49 1.05e-39 Reticulocyte fraction of red cells; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg11905131 chr22:24372483 LOC391322 0.54 12.21 0.43 5.69e-31 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9457247 0.508 rs6918286 chr6:167505829 C/T cg07741184 chr6:167504864 NA 0.32 9.87 0.36 1.78e-21 Crohn's disease; BRCA cis rs12216125 0.549 rs9358905 chr6:26077839 T/A cg17691542 chr6:26056736 HIST1H1C 0.53 11.44 0.41 1.06e-27 Iron status biomarkers; BRCA trans rs7980799 0.772 rs6488162 chr12:33593127 T/C cg26384229 chr12:38710491 ALG10B -0.41 -8.62 -0.32 5.42e-17 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs7927771 0.832 rs7924485 chr11:47419129 A/G cg20307385 chr11:47447363 PSMC3 0.42 8.78 0.33 1.48e-17 Subjective well-being; BRCA cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg10792982 chr14:105748885 BRF1 0.5 11.39 0.41 1.67e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg11189052 chr15:85197271 WDR73 -0.43 -7.96 -0.3 8.09e-15 Schizophrenia; BRCA cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg27129171 chr3:47204927 SETD2 0.57 12.93 0.46 3.79e-34 Colorectal cancer; BRCA cis rs8180040 0.629 rs7426969 chr3:47091355 T/C cg27129171 chr3:47204927 SETD2 0.72 17.7 0.57 2.28e-57 Colorectal cancer; BRCA cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.02e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs950776 0.518 rs4243083 chr15:78833830 C/G cg22563815 chr15:78856949 CHRNA5 -0.35 -8.43 -0.32 2.38e-16 Sudden cardiac arrest; BRCA cis rs1113500 0.933 rs11185255 chr1:108633191 T/A cg06207961 chr1:108661230 NA 0.46 11.24 0.41 6.95e-27 Growth-regulated protein alpha levels; BRCA cis rs12760731 0.641 rs11588490 chr1:178328139 T/A cg00404053 chr1:178313656 RASAL2 0.62 8.48 0.32 1.55e-16 Obesity-related traits; BRCA trans rs57221529 0.713 rs72703072 chr5:590626 A/G cg11887960 chr12:57824829 NA 0.52 8.15 0.31 1.89e-15 Lung disease severity in cystic fibrosis; BRCA cis rs4149577 0.630 rs4149570 chr12:6451590 A/C cg11268190 chr12:6442526 TNFRSF1A 0.27 7.96 0.3 7.96e-15 Monocyte count; BRCA cis rs9291683 0.588 rs13113730 chr4:10017628 C/T cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.81e-18 Bone mineral density; BRCA cis rs875971 0.577 rs34888281 chr7:65585771 C/T cg11764359 chr7:65958608 NA -0.61 -13.03 -0.46 1.35e-34 Aortic root size; BRCA cis rs10504229 1.000 rs67384205 chr8:58180348 C/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg03213289 chr20:61660250 NA 0.61 16.2 0.54 1e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs6121246 0.559 rs6060599 chr20:30257754 T/G cg21427119 chr20:30132790 HM13 -0.37 -8.34 -0.31 4.52e-16 Mean corpuscular hemoglobin; BRCA cis rs7772486 0.790 rs9497431 chr6:146248177 T/C cg13319975 chr6:146136371 FBXO30 0.42 9.39 0.35 1.02e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg19346786 chr7:2764209 NA -0.34 -10.04 -0.37 4.13e-22 Height; BRCA cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs6600671 0.934 rs12131379 chr1:121293437 T/C cg17023122 chr1:144479586 NA 0.34 7.88 0.3 1.38e-14 Hip geometry; BRCA cis rs7254827 0.737 rs71338609 chr19:17173418 A/G cg19418318 chr19:17219073 MYO9B -0.48 -10.04 -0.37 3.85e-22 Mean platelet volume; BRCA cis rs1451375 0.617 rs10276473 chr7:50612997 A/C cg18232548 chr7:50535776 DDC -0.42 -9.0 -0.34 2.54e-18 Malaria; BRCA cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg15839431 chr19:19639596 YJEFN3 -0.38 -8.36 -0.31 3.93e-16 Bipolar disorder; BRCA cis rs9291683 0.620 rs717615 chr4:10104670 C/T cg00071950 chr4:10020882 SLC2A9 0.5 11.98 0.43 5.81e-30 Bone mineral density; BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg00166722 chr3:10149974 C3orf24 -0.57 -11.37 -0.41 2.14e-27 Alzheimer's disease; BRCA cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.22e-36 Developmental language disorder (linguistic errors); BRCA cis rs1190552 0.846 rs3783382 chr14:102965437 A/T cg18135206 chr14:102964638 TECPR2 0.46 8.9 0.33 5.89e-18 Blood protein levels; BRCA cis rs6723226 0.638 rs6543657 chr2:32705085 T/C cg02381751 chr2:32503542 YIPF4 0.57 12.43 0.44 6.1e-32 Intelligence (multi-trait analysis); BRCA cis rs881375 0.678 rs2416804 chr9:123676396 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 -0.4 -7.89 -0.3 1.29e-14 Rheumatoid arthritis; BRCA cis rs77633900 0.614 rs2629021 chr15:76974083 C/T cg21673338 chr15:77095150 SCAPER -0.53 -9.84 -0.36 2.24e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs1568889 0.887 rs2062269 chr11:28116537 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.36 0.63 2.12e-71 Bipolar disorder; BRCA cis rs61935443 0.720 rs892493 chr12:95283943 T/C cg21533806 chr12:95267307 NA 0.44 8.63 0.32 4.7e-17 Schizophrenia; BRCA cis rs4631830 0.720 rs11004422 chr10:51498336 A/G cg20129853 chr10:51489980 NA 0.32 8.66 0.32 3.98e-17 Prostate-specific antigen levels; BRCA cis rs9814567 1.000 rs934093 chr3:134195885 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.89 -0.33 6.16e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6088813 1.000 rs4911492 chr20:33951799 G/A cg14752227 chr20:34000481 UQCC -0.4 -8.67 -0.32 3.66e-17 Height; BRCA cis rs4363385 0.818 rs1415966 chr1:153002864 A/G cg24667326 chr1:152973720 SPRR3 -0.32 -8.81 -0.33 1.17e-17 Inflammatory skin disease; BRCA cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg04586622 chr2:25135609 ADCY3 0.43 10.75 0.39 6.65e-25 Body mass index; BRCA cis rs9837602 0.688 rs11537816 chr3:99886662 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 8.48 0.32 1.57e-16 Breast cancer; BRCA cis rs8180040 0.729 rs11720439 chr3:47347003 T/G cg16586182 chr3:47516702 SCAP 0.6 13.3 0.47 8.12e-36 Colorectal cancer; BRCA cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg17366294 chr4:99064904 C4orf37 0.43 10.14 0.37 1.74e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg11764359 chr7:65958608 NA 0.65 11.67 0.42 1.12e-28 Aortic root size; BRCA cis rs10870270 0.500 rs9419217 chr10:133758379 A/G cg17892150 chr10:133769511 PPP2R2D -0.53 -11.74 -0.42 5.85e-29 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg19346786 chr7:2764209 NA 0.27 8.1 0.31 2.8e-15 Height; BRCA cis rs13191362 0.810 rs66921603 chr6:162996982 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.36 0.44 1.23e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2505998 0.787 rs28502801 chr10:43584039 A/T cg15436174 chr10:43711423 RASGEF1A -0.41 -7.98 -0.3 6.72e-15 Hirschsprung disease; BRCA cis rs17685 0.753 rs1637051 chr7:75730659 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.22 -0.31 1.14e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs992157 0.835 rs4674283 chr2:219144254 G/A cg00012203 chr2:219082015 ARPC2 -0.47 -9.22 -0.34 4.42e-19 Colorectal cancer; BRCA cis rs782590 0.517 rs13013133 chr2:55889466 G/A cg18811423 chr2:55921094 PNPT1 -0.52 -12.7 -0.45 4.25e-33 Metabolic syndrome; BRCA cis rs7772486 0.754 rs6921073 chr6:146144377 G/A cg05347473 chr6:146136440 FBXO30 0.38 7.86 0.3 1.61e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs17270561 0.609 rs9379783 chr6:25725207 C/T cg17691542 chr6:26056736 HIST1H1C 0.43 8.72 0.33 2.41e-17 Iron status biomarkers; BRCA cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg06547715 chr2:218990976 CXCR2 0.32 7.92 0.3 1.05e-14 Ulcerative colitis; BRCA cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg26314531 chr2:26401878 FAM59B -0.61 -10.0 -0.37 5.78e-22 Gut microbiome composition (summer); BRCA cis rs13040088 1.000 rs6090155 chr20:61527378 G/A cg23096297 chr20:61557774 DIDO1 0.89 17.1 0.56 3.08e-54 Menopause (age at onset); BRCA cis rs6831352 0.918 rs7669636 chr4:100059312 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.71 -0.42 7.56e-29 Alcohol dependence; BRCA cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg16405210 chr4:1374714 KIAA1530 -0.89 -22.13 -0.66 5.24e-81 Longevity; BRCA cis rs60871478 0.945 rs62432254 chr7:804175 C/T cg27478167 chr7:817139 HEATR2 -0.4 -8.46 -0.32 1.83e-16 Cerebrospinal P-tau181p levels; BRCA cis rs7959452 0.532 rs2291005 chr12:69764388 A/G cg22834771 chr12:69754056 YEATS4 -0.39 -9.64 -0.36 1.29e-20 Blood protein levels; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg02297831 chr4:17616191 MED28 0.38 8.22 0.31 1.17e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4808199 1.000 rs12972397 chr19:19562349 G/A cg03709012 chr19:19516395 GATAD2A 1.08 21.19 0.64 7.26e-76 Nonalcoholic fatty liver disease; BRCA cis rs17270561 0.583 rs7765833 chr6:25712433 C/A cg16482183 chr6:26056742 HIST1H1C 0.4 8.19 0.31 1.39e-15 Iron status biomarkers; BRCA cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg08859206 chr1:53392774 SCP2 -0.48 -10.31 -0.38 3.64e-23 Monocyte count; BRCA cis rs2282802 0.685 rs13177186 chr5:139640476 A/G cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.12e-15 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.875 rs10457793 chr6:146415403 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.79 -0.33 1.37e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2387326 0.717 rs12252256 chr10:129944616 C/T cg16087940 chr10:129947807 NA -0.44 -7.86 -0.3 1.6e-14 Select biomarker traits; BRCA cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.0 0.34 2.65e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs738322 0.967 rs4385 chr22:38573229 T/C cg25457927 chr22:38595422 NA -0.32 -11.94 -0.43 8.19e-30 Cutaneous nevi; BRCA cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs694739 1.000 rs1783521 chr11:64106291 T/C cg02228329 chr11:64053129 BAD;GPR137 0.48 10.02 0.37 4.57e-22 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs9807989 0.507 rs1420097 chr2:103009354 C/G cg03938978 chr2:103052716 IL18RAP -0.28 -8.21 -0.31 1.21e-15 Asthma; BRCA trans rs634534 0.562 rs1151505 chr11:65734539 C/T cg17712092 chr4:129076599 LARP1B 0.49 11.93 0.43 9.59e-30 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7809950 0.862 rs58391518 chr7:107030787 T/C cg23024343 chr7:107201750 COG5 -0.4 -8.97 -0.33 3.3e-18 Coronary artery disease; BRCA cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg18279126 chr7:2041391 MAD1L1 0.38 8.42 0.32 2.5e-16 Bipolar disorder and schizophrenia; BRCA cis rs701145 0.585 rs4680125 chr3:153784698 G/A cg17054900 chr3:154042577 DHX36 -0.54 -9.18 -0.34 5.74e-19 Coronary artery disease; BRCA cis rs8072100 0.875 rs7208530 chr17:45544107 C/T cg25173405 chr17:45401733 C17orf57 -0.55 -11.79 -0.42 3.5e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1215050 0.740 rs783963 chr4:98989070 A/G cg05340658 chr4:99064831 C4orf37 0.48 11.38 0.41 1.96e-27 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2011503 1.000 rs11085264 chr19:19621780 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1e-40 Motion sickness; BRCA cis rs9790314 0.586 rs16832279 chr3:161120483 C/T cg03342759 chr3:160939853 NMD3 -0.63 -14.19 -0.49 6.44e-40 Morning vs. evening chronotype; BRCA cis rs595982 0.527 rs73061658 chr19:49372376 G/C cg21252483 chr19:49399788 TULP2 -0.42 -9.36 -0.35 1.3e-19 Red cell distribution width; BRCA cis rs6952808 0.630 rs10239050 chr7:2158390 A/G cg21782813 chr7:2030301 MAD1L1 0.4 11.07 0.4 3.59e-26 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs2101864 chr8:58113226 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.89 -0.33 6.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg14196790 chr5:131705035 SLC22A5 0.32 8.52 0.32 1.16e-16 Breast cancer; BRCA cis rs5167 0.525 rs11083752 chr19:45454363 G/A cg13119609 chr19:45449297 APOC2 0.48 13.24 0.46 1.64e-35 Blood protein levels; BRCA cis rs10927875 0.541 rs1763599 chr1:16342602 C/T cg22431228 chr1:16359049 CLCNKA -0.44 -9.75 -0.36 5.02e-21 Dilated cardiomyopathy; BRCA cis rs2089162 1 rs2089162 chr15:78739763 A/G cg18825076 chr15:78729989 IREB2 -0.46 -8.76 -0.33 1.72e-17 Post bronchodilator FEV1/FVC ratio in COPD;Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs10751667 0.600 rs7394783 chr11:1005108 C/T cg20946044 chr11:1010712 AP2A2 0.37 7.89 0.3 1.32e-14 Alzheimer's disease (late onset); BRCA cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg00321850 chr1:175162397 KIAA0040 -0.44 -12.02 -0.43 3.83e-30 Diastolic blood pressure; BRCA cis rs16976116 0.855 rs28649719 chr15:55500211 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 1.000 rs7247672 chr19:37743928 A/G cg23950597 chr19:37808831 NA -0.65 -11.1 -0.4 2.75e-26 Coronary artery calcification; BRCA cis rs2197308 0.659 rs11181327 chr12:37903171 C/T cg13010199 chr12:38710504 ALG10B -0.41 -8.75 -0.33 1.88e-17 Morning vs. evening chronotype; BRCA cis rs2576037 0.583 rs4890698 chr18:44489725 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.67 -0.39 1.46e-24 Personality dimensions; BRCA cis rs780096 0.546 rs35073769 chr2:27731376 C/T cg22903471 chr2:27725779 GCKR -0.35 -8.34 -0.31 4.52e-16 Total body bone mineral density; BRCA cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg11266682 chr4:10021025 SLC2A9 0.46 11.52 0.41 4.8e-28 Bone mineral density; BRCA cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg03433033 chr1:76189801 ACADM 0.76 17.22 0.56 6.95e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10197940 0.710 rs4500942 chr2:152334580 A/G cg06191203 chr2:152266755 RIF1 -0.44 -12.85 -0.45 8.82e-34 Lung cancer; BRCA cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg27279351 chr12:120934652 DYNLL1 0.56 13.26 0.46 1.24e-35 High light scatter reticulocyte count; BRCA cis rs4975616 0.804 rs31489 chr5:1342714 C/A cg07493874 chr5:1342172 CLPTM1L -0.49 -13.55 -0.47 6.21e-37 Lung cancer; BRCA trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg03929089 chr4:120376271 NA -0.69 -13.62 -0.47 2.83e-37 Coronary artery disease; BRCA cis rs9394841 0.692 rs9349202 chr6:41805581 A/C cg08135965 chr6:41755394 TOMM6 0.52 8.35 0.31 4.14e-16 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs17270561 0.636 rs9393656 chr6:25722059 A/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.77 0.33 1.61e-17 Iron status biomarkers; BRCA cis rs7103648 0.695 rs12223593 chr11:47789082 T/G cg03711944 chr11:47377212 SPI1 -0.39 -9.25 -0.34 3.28e-19 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9287719 0.967 rs1541573 chr2:10773385 T/G cg02196655 chr2:10830764 NOL10 -0.3 -7.92 -0.3 1.04e-14 Prostate cancer; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg07092213 chr7:1199455 ZFAND2A -0.39 -7.9 -0.3 1.23e-14 Longevity;Endometriosis; BRCA cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg18964960 chr10:1102726 WDR37 -0.47 -8.45 -0.32 1.95e-16 Response to angiotensin II receptor blocker therapy; BRCA cis rs2762353 0.776 rs1165177 chr6:25829659 T/A cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg02187348 chr16:89574699 SPG7 0.49 11.66 0.42 1.23e-28 Multiple myeloma (IgH translocation); BRCA cis rs6665290 0.669 rs3768419 chr1:227173477 C/G cg10327440 chr1:227177885 CDC42BPA -1.07 -36.73 -0.82 1.21e-159 Myeloid white cell count; BRCA cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.85 0.33 8.55e-18 Motion sickness; BRCA cis rs3733585 0.638 rs28715627 chr4:9958140 T/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.45 -0.38 1.05e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4665809 0.590 rs13016807 chr2:26496186 G/C cg04944784 chr2:26401820 FAM59B 1.0 16.52 0.55 2.54e-51 Gut microbiome composition (summer); BRCA cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.05 -0.3 4.01e-15 Total body bone mineral density; BRCA cis rs6840360 0.615 rs6831810 chr4:152461995 A/G cg25486957 chr4:152246857 NA -0.36 -7.9 -0.3 1.26e-14 Intelligence (multi-trait analysis); BRCA cis rs6495122 0.501 rs12148488 chr15:75382542 G/T cg14664628 chr15:75095509 CSK 0.35 7.96 0.3 8.05e-15 Caffeine consumption;Diastolic blood pressure;Coffee consumption; BRCA cis rs11779988 0.545 rs404186 chr8:17795496 A/G cg01800426 chr8:17659068 MTUS1 -0.4 -8.21 -0.31 1.19e-15 Breast cancer; BRCA cis rs1707322 1.000 rs6675222 chr1:46326576 G/T cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.76e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12468557 0.545 rs7587791 chr2:211499979 A/C cg07063745 chr2:211341572 LANCL1;CPS1 -0.36 -8.04 -0.3 4.44e-15 Body mass index in asthmatics; BRCA cis rs9868809 0.505 rs28657585 chr3:48736216 A/T cg07636037 chr3:49044803 WDR6 -0.59 -8.54 -0.32 9.91e-17 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs10751667 0.621 rs11246375 chr11:999620 T/C cg01483505 chr11:975446 AP2A2 0.33 8.86 0.33 8.11e-18 Alzheimer's disease (late onset); BRCA cis rs7178424 0.875 rs7179506 chr15:62187955 T/G cg00456672 chr15:62358751 C2CD4A -0.41 -9.08 -0.34 1.32e-18 Height; BRCA cis rs600806 0.850 rs4970729 chr1:109979202 G/A cg20591472 chr1:110008990 SYPL2 0.33 8.24 0.31 9.86e-16 Intelligence (multi-trait analysis); BRCA cis rs7523273 1.000 rs12410786 chr1:207976205 T/A cg22525895 chr1:207977042 MIR29B2 -0.48 -11.88 -0.43 1.51e-29 Schizophrenia; BRCA trans rs8062405 0.824 rs4788084 chr16:28539848 C/T cg09719594 chr16:21412588 NA -0.34 -8.27 -0.31 7.88e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg22117172 chr7:91764530 CYP51A1 0.23 7.84 0.3 1.9e-14 Breast cancer; BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg13628971 chr7:2884303 GNA12 0.47 9.45 0.35 6.1e-20 Height; BRCA cis rs2439831 0.850 rs11070408 chr15:44034788 G/A cg27015174 chr15:43622946 ADAL;LCMT2 0.52 10.03 0.37 4.56e-22 Lung cancer in ever smokers; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg16606324 chr3:10149918 C3orf24 0.58 10.28 0.38 4.75e-23 Alzheimer's disease; BRCA cis rs965469 0.779 rs2207994 chr20:3294304 C/T cg25506879 chr20:3388711 C20orf194 -0.43 -8.71 -0.33 2.61e-17 IFN-related cytopenia; BRCA cis rs2204008 0.538 rs61931093 chr12:38242911 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.82 -0.36 2.68e-21 Bladder cancer; BRCA cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg11890956 chr21:40555474 PSMG1 -0.62 -13.8 -0.48 4.27e-38 Menarche (age at onset); BRCA cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg11764359 chr7:65958608 NA -0.74 -16.29 -0.54 3.72e-50 Aortic root size; BRCA cis rs11190604 0.943 rs11190574 chr10:102234331 T/C cg07080220 chr10:102295463 HIF1AN 0.47 10.57 0.39 3.61e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4363385 0.679 rs6686286 chr1:152984562 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -8.99 -0.34 2.75e-18 Inflammatory skin disease; BRCA cis rs6714710 0.603 rs34502870 chr2:98405929 A/G cg26665480 chr2:98280029 ACTR1B 0.58 13.58 0.47 4.32e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs7246657 0.943 rs10413602 chr19:37891492 T/C cg23950597 chr19:37808831 NA -0.75 -13.01 -0.46 1.65e-34 Coronary artery calcification; BRCA cis rs9473147 0.516 rs1931837 chr6:47442377 C/T cg12968598 chr6:47444699 CD2AP 0.45 9.38 0.35 1.1e-19 Platelet distribution width;Mean platelet volume; BRCA cis rs875971 0.862 rs6944374 chr7:65686929 C/G cg18876405 chr7:65276391 NA -0.51 -11.08 -0.4 3.14e-26 Aortic root size; BRCA cis rs7095944 0.585 rs7080838 chr10:126419841 A/G cg08799069 chr10:126477246 METTL10 0.38 8.9 0.33 5.58e-18 Asthma; BRCA cis rs8180040 0.726 rs7610636 chr3:47064436 A/C cg27129171 chr3:47204927 SETD2 -0.71 -17.51 -0.57 2.3e-56 Colorectal cancer; BRCA cis rs17125944 0.505 rs75838476 chr14:53242362 G/A cg00686598 chr14:53173677 PSMC6 1.25 16.47 0.55 4.61e-51 Alzheimer's disease (late onset); BRCA cis rs12586317 0.547 rs2038254 chr14:35462134 C/T cg16230307 chr14:35515116 FAM177A1 0.73 15.25 0.52 5.11e-45 Psoriasis; BRCA cis rs736408 0.812 rs9324 chr3:52825585 T/C cg18404041 chr3:52824283 ITIH1 -0.47 -14.62 -0.5 5.78e-42 Bipolar disorder; BRCA cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16024904 chr19:17905718 B3GNT3 0.38 8.05 0.3 4.16e-15 Tumor biomarkers; BRCA cis rs16854884 0.657 rs35067746 chr3:143747147 T/A cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA cis rs9287719 0.967 rs3815521 chr2:10743654 G/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs2836950 0.501 rs2070865 chr21:40715519 C/T cg17971929 chr21:40555470 PSMG1 -0.43 -9.21 -0.34 4.77e-19 Menarche (age at onset); BRCA cis rs801193 1.000 rs2707850 chr7:66203870 G/T cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs8072100 0.817 rs9912101 chr17:45547078 A/G cg08085267 chr17:45401833 C17orf57 -0.63 -14.02 -0.48 4.02e-39 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg11663144 chr21:46675770 NA 0.48 8.85 0.33 8.2e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3858526 0.628 rs4237762 chr11:5956626 A/C cg02574844 chr11:5959923 NA -0.43 -9.46 -0.35 5.71e-20 DNA methylation (variation); BRCA trans rs72766638 0.895 rs11795079 chr9:136930134 T/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.69 -9.95 -0.37 8.49e-22 Mosquito bite size; BRCA cis rs6540559 0.673 rs58637469 chr1:209971480 T/A cg22029157 chr1:209979665 IRF6 0.54 11.21 0.41 9.28e-27 Cleft lip with or without cleft palate; BRCA cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg04414720 chr1:150670196 GOLPH3L 0.37 8.39 0.32 3.06e-16 Melanoma; BRCA cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg13902645 chr11:5959945 NA -0.57 -11.6 -0.42 2.4e-28 DNA methylation (variation); BRCA cis rs858239 0.600 rs28646184 chr7:23139595 T/C cg23682824 chr7:23144976 KLHL7 0.46 12.31 0.44 2.15e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs11252926 0.650 rs4880678 chr10:490472 G/A cg18196295 chr10:418757 DIP2C 0.4 9.36 0.35 1.31e-19 Psychosis in Alzheimer's disease; BRCA cis rs35306767 0.903 rs34847097 chr10:902252 A/T cg20503657 chr10:835505 NA 1.01 17.77 0.58 1.09e-57 Eosinophil percentage of granulocytes; BRCA cis rs11190604 1.000 rs3793771 chr10:102222957 C/G cg07080220 chr10:102295463 HIF1AN 0.49 11.41 0.41 1.4e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10242455 0.702 rs73397481 chr7:99030108 C/T cg18809830 chr7:99032528 PTCD1 -0.67 -8.47 -0.32 1.63e-16 Blood metabolite levels; BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA trans rs804280 1.000 rs804280 chr8:11612698 G/T cg06636001 chr8:8085503 FLJ10661 0.47 10.16 0.37 1.43e-22 Myopia (pathological); BRCA cis rs9291683 0.546 rs6829727 chr4:10051672 A/C cg11266682 chr4:10021025 SLC2A9 0.43 11.09 0.4 2.84e-26 Bone mineral density; BRCA cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Parkinson's disease; BRCA cis rs61931739 0.500 rs7484658 chr12:34515879 A/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.26e-22 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs17604090 0.938 rs68072609 chr7:29682467 C/T cg19413766 chr7:29689036 LOC646762 -0.56 -7.83 -0.3 1.97e-14 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs4566357 0.615 rs10198214 chr2:227913314 A/C cg05526886 chr2:227700861 RHBDD1 -0.39 -8.12 -0.31 2.44e-15 Coronary artery disease; BRCA cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg25767906 chr1:53392781 SCP2 0.38 8.7 0.33 2.78e-17 Monocyte count; BRCA cis rs7098414 0.530 rs10749572 chr10:82136664 G/T cg01528321 chr10:82214614 TSPAN14 0.62 13.08 0.46 8.44e-35 Post bronchodilator FEV1; BRCA cis rs2153535 0.580 rs6597337 chr6:8531652 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.74 0.33 2.06e-17 Motion sickness; BRCA cis rs7267979 0.966 rs2261794 chr20:25263062 T/G cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2749592 0.611 rs2505199 chr10:38392457 G/A cg25427524 chr10:38739819 LOC399744 -0.66 -13.53 -0.47 7.74e-37 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1862618 0.853 rs252887 chr5:56166188 A/G cg22800045 chr5:56110881 MAP3K1 0.66 12.22 0.44 4.98e-31 Initial pursuit acceleration; BRCA cis rs4679121 0.642 rs55708952 chr3:126188912 A/G cg05485589 chr3:126194908 ZXDC -0.75 -8.42 -0.32 2.5e-16 Pursuit maintenance gain; BRCA cis rs9682041 0.561 rs9856511 chr3:170140165 C/G cg11886554 chr3:170076028 SKIL 0.41 7.86 0.3 1.59e-14 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg11764359 chr7:65958608 NA -0.75 -16.49 -0.55 3.67e-51 Aortic root size; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg11814155 chr7:99998594 ZCWPW1 0.42 7.85 0.3 1.71e-14 Platelet count; BRCA cis rs7666738 0.830 rs11097608 chr4:99011693 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.15 0.56 1.54e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs2191566 0.959 rs7256345 chr19:44510905 T/G cg20607764 chr19:44506953 ZNF230 -0.44 -9.95 -0.37 8.47e-22 Acute lymphoblastic leukemia (childhood); BRCA cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg13010199 chr12:38710504 ALG10B 0.44 8.84 0.33 9.41e-18 Bladder cancer; BRCA cis rs478304 0.934 rs610037 chr11:65546857 A/C cg08755490 chr11:65554678 OVOL1 0.54 11.35 0.41 2.51e-27 Acne (severe); BRCA cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.49 0.59 1.87e-61 Cognitive function; BRCA cis rs9296092 0.538 rs9461880 chr6:33518714 C/T cg13560919 chr6:33536144 NA -0.85 -17.59 -0.57 8.63e-57 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs72928364 1.000 rs13099053 chr3:100620904 C/A cg10123952 chr3:100791384 NA 0.54 8.07 0.3 3.62e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs595982 0.527 rs73061656 chr19:49372355 G/A cg21252483 chr19:49399788 TULP2 -0.42 -9.36 -0.35 1.3e-19 Red cell distribution width; BRCA cis rs708547 0.836 rs1713997 chr4:57843863 G/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.55 14.82 0.51 6.22e-43 Response to bleomycin (chromatid breaks); BRCA cis rs826838 0.838 rs11183646 chr12:38799846 A/T cg13010199 chr12:38710504 ALG10B 0.54 11.98 0.43 5.39e-30 Heart rate; BRCA cis rs651907 0.557 rs35117343 chr3:101445126 A/G cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.18 -0.31 1.59e-15 Colorectal cancer; BRCA cis rs7582180 0.629 rs6757754 chr2:100951273 C/T cg14675211 chr2:100938903 LONRF2 -0.42 -9.52 -0.35 3.51e-20 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs7647973 1.000 rs6783003 chr3:49524778 G/C cg07636037 chr3:49044803 WDR6 -0.77 -15.58 -0.52 1.31e-46 Menarche (age at onset); BRCA cis rs7666738 0.962 rs2865950 chr4:99040061 T/C cg07917127 chr4:99064746 C4orf37 0.41 7.84 0.3 1.94e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs708547 0.723 rs35982175 chr4:57841365 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.41 10.73 0.39 8.5e-25 Response to bleomycin (chromatid breaks); BRCA cis rs9393692 0.875 rs9358917 chr6:26284417 T/C cg13736514 chr6:26305472 NA -0.35 -11.82 -0.42 2.62e-29 Educational attainment; BRCA cis rs7727544 0.582 rs3828675 chr5:131546868 G/A cg14196790 chr5:131705035 SLC22A5 0.37 9.16 0.34 6.78e-19 Blood metabolite levels; BRCA cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -7.91 -0.3 1.14e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.94 0.51 1.58e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs1865760 0.865 rs9467651 chr6:25958257 C/G cg16482183 chr6:26056742 HIST1H1C 0.51 10.58 0.39 3.17e-24 Height; BRCA cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg08917208 chr2:24149416 ATAD2B -0.51 -7.93 -0.3 9.46e-15 Lymphocyte counts; BRCA trans rs931812 0.895 rs4734013 chr8:101908687 A/C cg20993868 chr7:22813445 NA 0.56 16.06 0.54 5.38e-49 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs4664304 0.620 rs2729705 chr2:160710922 T/C cg01092293 chr2:160761427 LY75 -0.35 -8.35 -0.31 4.11e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs10046574 0.519 rs112479683 chr7:135203288 G/A cg27474649 chr7:135195673 CNOT4 0.63 10.58 0.39 3.24e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7707921 0.881 rs57621982 chr5:81406770 C/T cg15871215 chr5:81402204 ATG10 -0.39 -8.21 -0.31 1.26e-15 Breast cancer; BRCA cis rs10463316 0.894 rs12153347 chr5:150765471 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.38 -0.31 3.35e-16 Metabolite levels (Pyroglutamine); BRCA trans rs11098499 0.697 rs6832410 chr4:120296800 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs7944584 0.611 rs10838696 chr11:47363285 A/G cg20307385 chr11:47447363 PSMC3 -0.61 -13.14 -0.46 4.32e-35 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.23 -0.41 7.76e-27 Lymphocyte counts; BRCA cis rs6783573 0.535 rs12637699 chr3:46628443 C/T cg16875182 chr3:46619291 LRRC2;TDGF1 -0.56 -10.35 -0.38 2.65e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs6867913 0.709 rs2338874 chr5:141466926 G/A cg08523384 chr5:141488047 NDFIP1 -0.35 -8.57 -0.32 7.82e-17 Asthma; BRCA cis rs7618501 0.633 rs7621026 chr3:49975334 A/G cg24110177 chr3:50126178 RBM5 -0.4 -10.95 -0.4 1.11e-25 Intelligence (multi-trait analysis); BRCA cis rs7385804 0.761 rs1734908 chr7:100313768 G/T cg16850897 chr7:100343110 ZAN 0.38 8.62 0.32 5.46e-17 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs7772486 0.658 rs9403737 chr6:145962193 G/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.45 -0.35 6.3e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs459571 0.959 rs408307 chr9:136892523 A/G cg13789015 chr9:136890014 NCRNA00094 -0.68 -14.52 -0.5 1.73e-41 Platelet distribution width; BRCA cis rs910873 0.505 rs6058089 chr20:33194257 C/T cg16810054 chr20:33298113 TP53INP2 0.47 10.14 0.37 1.7e-22 Melanoma; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg04025307 chr7:1156635 C7orf50 0.41 9.9 0.36 1.35e-21 Longevity;Endometriosis; BRCA cis rs34779708 0.931 rs35126129 chr10:35452141 G/A cg03585969 chr10:35415529 CREM 0.54 11.07 0.4 3.42e-26 Inflammatory bowel disease;Crohn's disease; BRCA trans rs629535 0.814 rs62513371 chr8:70077779 T/A cg21567404 chr3:27674614 NA -1.0 -21.77 -0.65 4.97e-79 Dupuytren's disease; BRCA trans rs9929218 0.861 rs8056206 chr16:68802072 G/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -13.75 -0.48 6.85e-38 Colorectal cancer; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg00814883 chr7:100076585 TSC22D4 -0.54 -11.49 -0.41 6.45e-28 Platelet count; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.5 10.3 0.38 4.14e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg11833968 chr6:79620685 NA -0.46 -10.19 -0.37 1.11e-22 Intelligence (multi-trait analysis); BRCA cis rs11764590 0.694 rs11773643 chr7:2104063 A/G cg02951883 chr7:2050386 MAD1L1 0.39 8.36 0.31 3.89e-16 Neuroticism; BRCA cis rs7914558 0.966 rs2065977 chr10:104729415 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.71 0.39 1.02e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6121246 0.954 rs73241710 chr20:30424956 G/A cg13852791 chr20:30311386 BCL2L1 0.79 15.11 0.51 2.57e-44 Mean corpuscular hemoglobin; BRCA cis rs11055008 0.620 rs2111941 chr12:12829404 A/T cg04607235 chr12:12878440 APOLD1 0.42 8.33 0.31 4.9e-16 Pulse pressure; BRCA cis rs4819052 0.840 rs914217 chr21:46698299 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 14.89 0.51 3.04e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs8073060 0.586 rs2626625 chr17:34027607 C/G cg19694781 chr19:47549865 TMEM160 -1.08 -21.33 -0.64 1.19e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs3858526 0.584 rs10769266 chr11:5858460 C/T cg05234568 chr11:5960015 NA -0.43 -8.94 -0.33 4.05e-18 DNA methylation (variation); BRCA cis rs4285028 0.699 rs1574115 chr3:121469225 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.87 -15.37 -0.52 1.28e-45 Multiple sclerosis; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg08470875 chr2:26401718 FAM59B -0.7 -11.27 -0.41 5.41e-27 Gut microbiome composition (summer); BRCA cis rs1595825 0.891 rs6751690 chr2:198574523 G/A cg19156104 chr2:198669113 PLCL1 -0.46 -8.24 -0.31 9.94e-16 Ulcerative colitis; BRCA trans rs61931739 0.635 rs1352208 chr12:33932543 T/C cg26384229 chr12:38710491 ALG10B 0.39 8.91 0.33 5.5e-18 Morning vs. evening chronotype; BRCA cis rs1997103 1.000 rs6945937 chr7:55407140 C/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2346177 0.605 rs7556828 chr2:46663172 A/G cg02822958 chr2:46747628 ATP6V1E2 -0.48 -9.89 -0.36 1.44e-21 HDL cholesterol; BRCA cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg15501526 chr10:2543763 NA 0.59 13.42 0.47 2.44e-36 Age-related hearing impairment; BRCA cis rs2806561 0.765 rs1757046 chr1:23511821 T/C cg12483005 chr1:23474871 LUZP1 0.45 9.94 0.37 9.75e-22 Height; BRCA cis rs2204008 0.657 rs8186888 chr12:38334260 T/G cg26384229 chr12:38710491 ALG10B 0.5 11.45 0.41 9.62e-28 Bladder cancer; BRCA cis rs13191362 1.000 rs34228197 chr6:163008232 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.29 0.31 6.45e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg18806716 chr10:30721971 MAP3K8 -0.46 -10.85 -0.39 2.64e-25 Inflammatory bowel disease; BRCA cis rs9858542 0.953 rs34363169 chr3:49537712 G/A cg03060546 chr3:49711283 APEH -0.53 -10.62 -0.39 2.21e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg07828340 chr4:882639 GAK 1.03 12.5 0.44 3.04e-32 Intelligence (multi-trait analysis); BRCA cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg11843238 chr5:131593191 PDLIM4 0.31 7.89 0.3 1.36e-14 Blood metabolite levels; BRCA cis rs28735056 0.935 rs11662267 chr18:77641902 C/G cg20368463 chr18:77673604 PQLC1 -0.34 -7.91 -0.3 1.1e-14 Schizophrenia; BRCA cis rs6545883 0.931 rs778768 chr2:61790289 C/G cg15711740 chr2:61764176 XPO1 -0.56 -14.11 -0.49 1.51e-39 Tuberculosis; BRCA cis rs2346177 0.554 rs13002880 chr2:46708129 C/G cg02822958 chr2:46747628 ATP6V1E2 0.58 11.31 0.41 3.68e-27 HDL cholesterol; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg13880726 chr7:1868755 MAD1L1 0.52 10.3 0.38 4.07e-23 Bipolar disorder and schizophrenia; BRCA cis rs10193935 0.901 rs10200000 chr2:42442212 A/G cg27598129 chr2:42591480 NA -0.95 -15.18 -0.51 1.18e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg01283332 chr5:1856932 NA -0.35 -8.45 -0.32 1.91e-16 Cardiovascular disease risk factors; BRCA cis rs1707322 1.000 rs11211219 chr1:46359478 G/C cg03146154 chr1:46216737 IPP 0.45 10.05 0.37 3.69e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7766436 0.885 rs13202434 chr6:22583694 G/C cg13666174 chr6:22585274 NA -0.49 -11.63 -0.42 1.65e-28 Coronary artery disease; BRCA trans rs9409565 0.787 rs11789704 chr9:97233408 C/T cg05679027 chr9:99775184 HIATL2 -0.35 -7.94 -0.3 9.11e-15 Colorectal cancer (alcohol consumption interaction); BRCA cis rs919433 0.963 rs12618612 chr2:198171058 G/T cg10820045 chr2:198174542 NA -0.39 -8.07 -0.3 3.47e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg26608667 chr7:1196370 ZFAND2A 0.35 8.06 0.3 3.67e-15 Longevity;Endometriosis; BRCA cis rs798766 0.779 rs55895920 chr4:1735930 C/T cg05874882 chr4:1763078 NA -0.47 -8.51 -0.32 1.19e-16 Bladder cancer;Urinary bladder cancer; BRCA cis rs13095912 0.752 rs62291883 chr3:185313842 T/C cg11274856 chr3:185301563 NA 0.52 12.35 0.44 1.46e-31 Systolic blood pressure; BRCA cis rs6500602 0.701 rs4786508 chr16:4568043 G/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.24 0.31 9.41e-16 Schizophrenia; BRCA cis rs62158211 0.955 rs1823125 chr2:114090412 C/T cg17784749 chr2:114082611 LOC440839 -0.54 -9.55 -0.35 2.72e-20 Sleep duration (oversleepers vs undersleepers);Sleep traits (multi-trait analysis);Sleep duration; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg22907277 chr7:1156413 C7orf50 0.59 9.11 0.34 1.09e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8058578 1.000 rs2289442 chr16:30739919 A/G cg02466173 chr16:30829666 NA -0.53 -11.5 -0.41 6.03e-28 Multiple myeloma; BRCA trans rs61931739 0.534 rs4931783 chr12:34115322 G/A cg13010199 chr12:38710504 ALG10B 0.46 9.04 0.34 1.78e-18 Morning vs. evening chronotype; BRCA cis rs757110 0.745 rs10734252 chr11:17404839 G/A cg04705435 chr11:17411270 KCNJ11 0.44 9.36 0.35 1.35e-19 Type 2 diabetes; BRCA cis rs72781680 0.611 rs72783636 chr2:24328706 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.16 0.31 1.77e-15 Lymphocyte counts; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.54 -8.6 -0.32 6.1e-17 Gut microbiome composition (summer); BRCA cis rs72781680 0.611 rs55868657 chr2:24295385 G/A cg20701182 chr2:24300061 SF3B14 0.71 13.55 0.47 6.09e-37 Lymphocyte counts; BRCA cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg00631329 chr6:26305371 NA -0.55 -15.74 -0.53 2.01e-47 Educational attainment; BRCA cis rs10876993 0.893 rs3825078 chr12:58089413 A/T cg18357645 chr12:58087776 OS9 0.47 13.29 0.47 8.77e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs7267979 0.966 rs2482923 chr20:25308981 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.6 -0.32 6.2e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.830 rs9307218 chr4:99024885 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.58 0.55 1.29e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs30380 1.000 rs151964 chr5:96123666 G/T cg16492584 chr5:96139282 ERAP1 -0.31 -7.9 -0.3 1.19e-14 Cerebrospinal fluid biomarker levels; BRCA cis rs853679 0.517 rs9366715 chr6:28064633 A/G cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.2 -0.31 1.28e-15 Depression; BRCA cis rs2625529 0.824 rs12906711 chr15:72215065 A/G cg16672083 chr15:72433130 SENP8 -0.83 -17.16 -0.56 1.39e-54 Red blood cell count; BRCA cis rs765787 0.530 rs1706837 chr15:45519036 A/G cg15395560 chr15:45543142 SLC28A2 0.3 8.43 0.32 2.33e-16 Uric acid levels; BRCA cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg09184832 chr6:79620586 NA -0.47 -10.25 -0.38 6.3e-23 Intelligence (multi-trait analysis); BRCA trans rs9858542 1.000 rs11718165 chr3:49696797 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.04 -0.34 1.92e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs514406 0.893 rs512723 chr1:53343880 C/T cg08859206 chr1:53392774 SCP2 0.52 10.73 0.39 8.36e-25 Monocyte count; BRCA cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg09455208 chr3:40491958 NA 0.41 9.69 0.36 8.45e-21 Renal cell carcinoma; BRCA cis rs35306767 0.807 rs34527494 chr10:935192 T/C cg26597838 chr10:835615 NA 1.29 21.15 0.64 1.22e-75 Eosinophil percentage of granulocytes; BRCA cis rs7255436 0.965 rs12981318 chr19:8451430 G/A cg10174797 chr19:8464628 RAB11B 0.35 9.01 0.34 2.4e-18 HDL cholesterol; BRCA cis rs2075371 1.000 rs2244694 chr7:133987093 C/T cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.36e-36 Mean platelet volume; BRCA cis rs208520 0.955 rs208538 chr6:66964492 C/G cg07460842 chr6:66804631 NA -0.79 -13.3 -0.47 8.34e-36 Exhaled nitric oxide output; BRCA cis rs12612619 0.732 rs6716275 chr2:27227707 C/T cg00617064 chr2:27272375 NA 0.31 8.34 0.31 4.45e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg05535760 chr7:792225 HEATR2 -0.73 -11.8 -0.42 3.22e-29 Cerebrospinal P-tau181p levels; BRCA trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg03929089 chr4:120376271 NA -0.69 -13.25 -0.46 1.44e-35 Coronary artery disease; BRCA cis rs13064411 0.542 rs11537650 chr3:113222036 G/A cg18753928 chr3:113234510 CCDC52 -0.46 -9.82 -0.36 2.69e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs6840360 0.550 rs7689266 chr4:152561048 T/C cg22705602 chr4:152727874 NA -0.34 -8.55 -0.32 9.01e-17 Intelligence (multi-trait analysis); BRCA cis rs16958440 1.000 rs2289131 chr18:44602864 G/A cg17192377 chr18:44677553 HDHD2 0.65 9.52 0.35 3.37e-20 Sitting height ratio; BRCA cis rs738321 0.762 rs4820321 chr22:38579569 T/A cg25457927 chr22:38595422 NA -0.39 -13.29 -0.47 8.77e-36 Breast cancer; BRCA cis rs6450176 1.000 rs60652351 chr5:53306140 T/C ch.5.1024479R chr5:53302184 ARL15 -0.64 -15.32 -0.52 2.36e-45 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg22800045 chr5:56110881 MAP3K1 0.63 12.3 0.44 2.43e-31 Initial pursuit acceleration; BRCA cis rs35110281 0.840 rs2838331 chr21:45026728 A/G cg01579765 chr21:45077557 HSF2BP 0.44 11.86 0.42 1.91e-29 Mean corpuscular volume; BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg11814155 chr7:99998594 ZCWPW1 0.45 8.16 0.31 1.73e-15 Platelet count; BRCA cis rs6089829 0.962 rs6011548 chr20:61666063 C/T cg08045932 chr20:61659980 NA 0.49 11.18 0.4 1.31e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs13191362 1.000 rs13210756 chr6:163009030 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.75 0.33 1.9e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs17685 0.753 rs6464999 chr7:75787315 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4363385 0.782 rs1933381 chr1:153003255 C/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.44 -0.32 2.1e-16 Inflammatory skin disease; BRCA cis rs2836974 0.674 rs1011413 chr21:40638241 A/G cg06238570 chr21:40685208 BRWD1 -0.42 -8.51 -0.32 1.22e-16 Cognitive function; BRCA cis rs7584330 0.910 rs880932 chr2:238396963 A/G cg14458575 chr2:238380390 NA 0.58 13.17 0.46 3.22e-35 Prostate cancer; BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg13628971 chr7:2884303 GNA12 0.48 9.51 0.35 3.67e-20 Height; BRCA cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.85 -0.33 8.29e-18 Alzheimer's disease (late onset); BRCA cis rs769267 0.965 rs13964 chr19:19468710 C/G cg01262667 chr19:19385393 TM6SF2 -0.41 -10.61 -0.39 2.37e-24 Tonsillectomy; BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg05564831 chr3:52568323 NT5DC2 0.34 8.06 0.3 3.88e-15 Electroencephalogram traits; BRCA cis rs7267979 1.000 rs2474777 chr20:25272633 A/G cg08601574 chr20:25228251 PYGB 0.34 8.31 0.31 5.72e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6582630 0.555 rs10880611 chr12:38509316 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.66 0.57 3.84e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs597539 0.652 rs602805 chr11:68662076 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 18.46 0.59 2.66e-61 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7301016 0.846 rs7302094 chr12:62967430 C/T cg11441379 chr12:63026424 NA 0.46 8.69 0.32 3.13e-17 IgG glycosylation; BRCA cis rs62229266 0.740 rs4817759 chr21:37389559 G/A cg12218747 chr21:37451666 NA -0.34 -8.02 -0.3 4.91e-15 Mitral valve prolapse; BRCA cis rs7904368 0.806 rs6602161 chr10:16862280 A/G cg23933602 chr10:16859644 RSU1 0.52 8.59 0.32 6.41e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs17376456 0.877 rs7702521 chr5:93484579 G/T cg25358565 chr5:93447407 FAM172A 1.23 19.33 0.61 6.85e-66 Diabetic retinopathy; BRCA cis rs3806843 1.000 rs3733708 chr5:140181734 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.82e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6570726 0.791 rs448939 chr6:145808320 T/C cg23711669 chr6:146136114 FBXO30 0.61 13.95 0.48 8.27e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs10012167 chr4:99048579 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.580 rs11246363 chr11:971667 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.81 0.55 9.28e-53 Alzheimer's disease (late onset); BRCA trans rs61931739 0.500 rs11053185 chr12:34428857 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.12 0.34 9.77e-19 Morning vs. evening chronotype; BRCA cis rs832540 0.931 rs832535 chr5:56213334 C/T cg24531977 chr5:56204891 C5orf35 -0.44 -8.99 -0.33 2.86e-18 Coronary artery disease; BRCA cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg06453172 chr10:134556979 INPP5A -0.48 -10.3 -0.38 4.04e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7208859 0.673 rs73265612 chr17:29225983 A/G cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs11677370 0.603 rs10171309 chr2:3851690 C/T cg17052675 chr2:3827356 NA -0.53 -12.84 -0.45 1.02e-33 Type 2 diabetes; BRCA trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs7178424 1.000 rs17271431 chr15:62381016 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.21 -0.31 1.27e-15 Height; BRCA cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg05623727 chr3:50126028 RBM5 0.41 9.74 0.36 5.59e-21 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.32 0.57 2.11e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs9815354 0.812 rs4577439 chr3:41952540 T/A cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs3733585 0.699 rs7657340 chr4:9966772 A/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.23e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg21143896 chr7:2802374 GNA12 -0.31 -8.25 -0.31 9.37e-16 Height; BRCA cis rs7818345 0.845 rs11785649 chr8:19268233 G/A cg11303988 chr8:19266685 CSGALNACT1 0.35 8.93 0.33 4.59e-18 Language performance in older adults (adjusted for episodic memory); BRCA cis rs2795502 0.872 rs2744062 chr10:43254789 T/A cg20628663 chr10:43360327 NA -0.7 -11.87 -0.43 1.67e-29 Blood protein levels; BRCA cis rs10129255 0.518 rs7143784 chr14:107143294 A/G cg07958169 chr14:107095056 NA -0.37 -7.91 -0.3 1.13e-14 Kawasaki disease; BRCA cis rs2625529 0.824 rs55854204 chr15:72433182 C/T cg16672083 chr15:72433130 SENP8 -0.86 -18.21 -0.58 5.62e-60 Red blood cell count; BRCA trans rs7824557 0.767 rs6985146 chr8:11170721 A/C cg06636001 chr8:8085503 FLJ10661 0.49 9.21 0.34 4.52e-19 Retinal vascular caliber; BRCA cis rs6088580 0.608 rs2105109 chr20:32971932 A/G cg06115741 chr20:33292138 TP53INP2 -0.4 -8.8 -0.33 1.25e-17 Glomerular filtration rate (creatinine); BRCA trans rs11098499 0.738 rs34965784 chr4:120361586 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.38e-14 Corneal astigmatism; BRCA cis rs11711311 1.000 rs34475696 chr3:113458293 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA cis rs7618915 0.547 rs13085895 chr3:52678270 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.9 0.36 1.36e-21 Bipolar disorder; BRCA cis rs10504229 0.906 rs73607868 chr8:58172482 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.836 rs8129355 chr21:40579869 A/G cg17971929 chr21:40555470 PSMG1 0.79 18.65 0.59 2.76e-62 Cognitive function; BRCA cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.29 0.47 9.05e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11098499 0.754 rs1511017 chr4:120250805 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA trans rs11039798 0.588 rs7479642 chr11:48553808 G/T cg15704280 chr7:45808275 SEPT13 0.52 8.92 0.33 4.69e-18 Axial length; BRCA cis rs7524258 0.867 rs35399313 chr1:7277293 T/C cg07173049 chr1:7289937 CAMTA1 0.37 8.98 0.33 2.96e-18 Tourette's syndrome or obsessive-compulsive disorder; BRCA trans rs2562456 0.876 rs62110163 chr19:21728822 G/A cg25042112 chr7:64838748 ZNF92 -0.45 -8.34 -0.31 4.45e-16 Pain; BRCA cis rs4919694 0.611 rs77328741 chr10:105066314 T/C cg04362960 chr10:104952993 NT5C2 0.72 11.29 0.41 4.47e-27 Arsenic metabolism; BRCA cis rs796364 0.806 rs11679658 chr2:200923081 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.76 -11.5 -0.41 5.98e-28 Schizophrenia; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg25036284 chr2:26402008 FAM59B -0.7 -12.28 -0.44 3e-31 Gut microbiome composition (summer); BRCA cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.760 rs11690371 chr2:200989616 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -9.79 -0.36 3.39e-21 Schizophrenia; BRCA cis rs6545883 0.894 rs6709441 chr2:61436930 A/T cg15711740 chr2:61764176 XPO1 0.53 12.99 0.46 2.13e-34 Tuberculosis; BRCA cis rs17641971 0.662 rs1828495 chr8:49945281 C/T cg00325661 chr8:49890786 NA 0.37 10.31 0.38 3.54e-23 Blood metabolite levels; BRCA cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg11644478 chr21:40555479 PSMG1 -0.67 -14.51 -0.5 1.86e-41 Cognitive function; BRCA cis rs9399135 0.967 rs4388304 chr6:135309597 T/A cg24558204 chr6:135376177 HBS1L 0.46 12.6 0.45 1.19e-32 Red blood cell count; BRCA cis rs11997175 0.766 rs6983113 chr8:33699513 G/A ch.8.33884649F chr8:33765107 NA 0.34 8.0 0.3 5.85e-15 Body mass index; BRCA cis rs7618501 0.521 rs11130222 chr3:49901060 A/T cg05623727 chr3:50126028 RBM5 0.51 12.25 0.44 3.9e-31 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg10802521 chr3:52805072 NEK4 -0.33 -8.53 -0.32 1.07e-16 Bipolar disorder; BRCA cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg23583168 chr7:148888333 NA -0.83 -19.15 -0.6 5.92e-65 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 21.43 0.65 3.48e-77 Platelet count; BRCA cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.7e-17 Developmental language disorder (linguistic errors); BRCA trans rs6089829 0.889 rs6122348 chr20:61663921 C/T cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs11098499 0.604 rs17051352 chr4:120581427 G/A cg09307838 chr4:120376055 NA 0.59 10.95 0.4 1.11e-25 Corneal astigmatism; BRCA trans rs75804782 0.521 rs72994973 chr2:239428315 C/T cg01134436 chr17:81009848 B3GNTL1 0.69 8.81 0.33 1.17e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs8072100 0.935 rs8070759 chr17:45638760 C/T cg25173405 chr17:45401733 C17orf57 0.47 9.73 0.36 5.82e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4906332 1.000 rs17617832 chr14:103943140 T/C cg04998671 chr14:104000505 TRMT61A -0.43 -9.5 -0.35 4.27e-20 Coronary artery disease; BRCA cis rs11605924 0.766 rs12419690 chr11:45858584 G/A ch.11.939596F chr11:45881766 CRY2 -0.44 -9.64 -0.36 1.28e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26314531 chr2:26401878 FAM59B -0.66 -11.2 -0.4 1.08e-26 Gut microbiome composition (summer); BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg00814883 chr7:100076585 TSC22D4 -0.48 -9.92 -0.37 1.19e-21 Platelet count; BRCA cis rs10992471 0.528 rs1535754 chr9:95201917 T/G cg14631576 chr9:95140430 CENPP -0.35 -8.66 -0.32 3.97e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs250677 0.687 rs250672 chr5:148446110 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -8.69 -0.33 3.04e-17 Breast cancer; BRCA trans rs11088226 0.681 rs8131384 chr21:33944127 C/T cg09050820 chr6:167586206 TCP10L2 0.84 14.52 0.5 1.73e-41 Gastritis; BRCA cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.5 -10.21 -0.37 9.19e-23 Personality dimensions; BRCA cis rs4642101 0.694 rs12631514 chr3:12838293 G/C cg05775895 chr3:12838266 CAND2 0.39 8.62 0.32 5.1e-17 QRS complex (12-leadsum); BRCA cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg14844989 chr11:31128820 NA -0.43 -9.18 -0.34 6.07e-19 Red blood cell count; BRCA cis rs2290405 0.527 rs7663192 chr4:923947 T/C cg04824913 chr4:887549 GAK 0.76 14.97 0.51 1.26e-43 Systemic sclerosis; BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg21724239 chr8:58056113 NA 0.66 10.45 0.38 1.05e-23 Developmental language disorder (linguistic errors); BRCA cis rs4076764 0.846 rs7525724 chr1:163426372 G/A cg24596788 chr1:163392923 NA -0.32 -8.53 -0.32 1.06e-16 Motion sickness; BRCA cis rs3820928 0.874 rs7576081 chr2:227843634 C/G cg11843606 chr2:227700838 RHBDD1 -0.37 -8.33 -0.31 4.85e-16 Pulmonary function; BRCA cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg16145915 chr7:1198662 ZFAND2A -0.42 -8.05 -0.3 4.01e-15 Bronchopulmonary dysplasia; BRCA cis rs17345786 1.000 rs3762729 chr3:101308874 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 11.73 0.42 6.55e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 0.726 rs2305638 chr3:47046842 G/C cg16586182 chr3:47516702 SCAP -0.54 -12.16 -0.43 9.16e-31 Colorectal cancer; BRCA cis rs4713118 0.696 rs2394002 chr6:27748015 G/A cg20933634 chr6:27740509 NA 0.48 9.52 0.35 3.58e-20 Parkinson's disease; BRCA trans rs75804782 0.641 rs55844289 chr2:239323207 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 9.69 0.36 8.3e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs867371 0.896 rs6495647 chr15:82537049 C/G cg00614314 chr15:82944287 LOC80154 0.43 8.95 0.33 3.83e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs6570726 0.791 rs11155426 chr6:145817130 T/C cg13319975 chr6:146136371 FBXO30 -0.42 -9.63 -0.36 1.39e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs528301 0.707 rs338070 chr2:45175289 C/G cg02372786 chr2:45167549 SIX3 -0.57 -13.11 -0.46 5.91e-35 Alcohol and nicotine co-dependence; BRCA cis rs514406 0.929 rs515857 chr1:53336859 A/G cg27535305 chr1:53392650 SCP2 -0.34 -7.98 -0.3 6.67e-15 Monocyte count; BRCA cis rs3857536 0.740 rs7769722 chr6:66891363 C/T cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs11690935 0.959 rs6758704 chr2:172655097 T/C cg13550731 chr2:172543902 DYNC1I2 -0.91 -30.23 -0.77 2.47e-125 Schizophrenia; BRCA cis rs4689388 0.793 rs4234731 chr4:6299914 A/G cg25554036 chr4:6271136 WFS1 0.42 9.79 0.36 3.61e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs12950390 0.853 rs56387656 chr17:45860189 C/G cg24803719 chr17:45855879 NA -0.31 -8.05 -0.3 4.15e-15 IgG glycosylation; BRCA cis rs6088580 0.634 rs6141471 chr20:33006730 A/G cg24642439 chr20:33292090 TP53INP2 -0.54 -11.66 -0.42 1.31e-28 Glomerular filtration rate (creatinine); BRCA cis rs921968 0.541 rs561570 chr2:219379348 T/A cg02176678 chr2:219576539 TTLL4 0.46 11.84 0.42 2.25e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg08888203 chr3:10149979 C3orf24 0.67 13.89 0.48 1.65e-38 Alzheimer's disease; BRCA cis rs61990749 0.597 rs176971 chr14:78191599 T/G cg02301378 chr14:78227641 SNW1;C14orf178 0.63 9.68 0.36 8.69e-21 Fibroblast growth factor basic levels; BRCA cis rs57590327 0.503 rs7631052 chr3:81866235 C/A cg07356753 chr3:81810745 GBE1 -0.42 -9.84 -0.36 2.19e-21 Extraversion; BRCA cis rs4862750 0.794 rs1030382 chr4:187903782 T/G cg07414643 chr4:187882934 NA 0.29 9.91 0.37 1.21e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs13082711 0.554 rs34066402 chr3:27387987 G/A cg02860705 chr3:27208620 NA 0.68 11.74 0.42 5.98e-29 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs4285028 0.747 rs3732407 chr3:121416623 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.86 -15.24 -0.52 5.66e-45 Multiple sclerosis; BRCA cis rs9986765 1.000 rs28672333 chr7:142826798 G/A cg22531018 chr7:142981779 TMEM139 0.58 9.72 0.36 6.44e-21 Cancer;Dermatomyositis; BRCA cis rs801193 0.548 rs2659891 chr7:66201114 A/G cg18876405 chr7:65276391 NA 0.48 10.79 0.39 4.64e-25 Aortic root size; BRCA cis rs13191362 1.000 rs34655790 chr6:163202739 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.82 0.36 2.72e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72634258 0.520 rs12078018 chr1:7857309 G/A cg26816564 chr1:7831052 VAMP3 0.69 12.67 0.45 5.73e-33 Inflammatory bowel disease; BRCA cis rs877282 1.000 rs11253370 chr10:773712 G/A cg17470449 chr10:769945 NA 0.49 9.36 0.35 1.37e-19 Uric acid levels; BRCA cis rs9467773 0.587 rs9467722 chr6:26352566 T/C cg09904177 chr6:26538194 HMGN4 -0.32 -8.57 -0.32 7.66e-17 Intelligence (multi-trait analysis); BRCA trans rs783540 0.681 rs1259178 chr15:83271876 T/C cg18393722 chr15:85113863 UBE2QP1 -0.32 -8.85 -0.33 8.66e-18 Schizophrenia; BRCA cis rs507080 0.883 rs693306 chr11:118558333 A/G cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA trans rs35110281 0.627 rs1836855 chr21:44965414 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.87 0.33 7.08e-18 Mean corpuscular volume; BRCA cis rs7586879 0.681 rs6756609 chr2:25121125 C/A cg01884057 chr2:25150051 NA 0.34 9.06 0.34 1.55e-18 Body mass index; BRCA cis rs10870270 0.957 rs7074604 chr10:133740373 G/C cg26149184 chr10:133730230 NA 0.4 8.2 0.31 1.37e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4930561 0.765 rs10896304 chr11:67981714 T/G cg16338278 chr11:67432957 ALDH3B2 0.43 8.62 0.32 5.39e-17 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs79839061 0.536 rs3775128 chr4:885828 T/C cg07828340 chr4:882639 GAK 0.58 9.2 0.34 5.08e-19 Intelligence (multi-trait analysis); BRCA cis rs11764590 0.651 rs12673687 chr7:2081873 C/T cg23422044 chr7:1970798 MAD1L1 -0.44 -9.26 -0.34 3.01e-19 Neuroticism; BRCA cis rs832540 1.000 rs252914 chr5:56198150 A/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.36 -0.31 3.98e-16 Coronary artery disease; BRCA cis rs2991971 0.716 rs7532573 chr1:45915892 A/T cg24296786 chr1:45957014 TESK2 -0.56 -13.19 -0.46 2.75e-35 High light scatter reticulocyte count; BRCA cis rs36051895 0.695 rs12352214 chr9:5018041 G/A cg02405213 chr9:5042618 JAK2 -0.45 -8.41 -0.32 2.76e-16 Pediatric autoimmune diseases; BRCA cis rs8103278 0.507 rs16939 chr19:46276056 C/A cg12641515 chr19:46296257 DMWD 0.68 16.63 0.55 7.35e-52 Coronary artery disease; BRCA trans rs2204008 0.774 rs11495721 chr12:38337224 A/C cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 1e-16 Bladder cancer; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg11814155 chr7:99998594 ZCWPW1 0.46 8.24 0.31 9.66e-16 Platelet count; BRCA cis rs6121246 0.559 rs6060621 chr20:30261562 G/C cg21427119 chr20:30132790 HM13 -0.36 -8.17 -0.31 1.71e-15 Mean corpuscular hemoglobin; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg10819733 chr22:24237672 NA 0.3 8.28 0.31 7.12e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2070488 0.931 rs7630012 chr3:38552250 A/G cg24069376 chr3:38537580 EXOG -0.42 -11.91 -0.43 1.13e-29 Electrocardiographic conduction measures; BRCA cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg26031613 chr14:104095156 KLC1 -0.55 -9.7 -0.36 7.4e-21 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs3762637 1.000 rs7609972 chr3:122199426 T/G cg24169773 chr3:122142474 KPNA1 -0.43 -8.04 -0.3 4.29e-15 LDL cholesterol levels; BRCA cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg01802117 chr1:53393560 SCP2 -0.36 -8.31 -0.31 5.97e-16 Monocyte count; BRCA cis rs10924970 0.781 rs10802589 chr1:235444049 A/G cg26050004 chr1:235667680 B3GALNT2 0.35 8.74 0.33 2.02e-17 Asthma; BRCA cis rs4713118 0.869 rs10214440 chr6:27702440 A/C cg20933634 chr6:27740509 NA 0.45 9.01 0.34 2.3e-18 Parkinson's disease; BRCA cis rs877282 0.842 rs35117541 chr10:764683 C/T cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA cis rs189798 0.807 rs9949 chr8:8994512 A/G cg06636001 chr8:8085503 FLJ10661 0.49 8.48 0.32 1.58e-16 Myopia (pathological); BRCA cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg18016565 chr1:150552671 MCL1 0.35 8.02 0.3 5.04e-15 Melanoma; BRCA cis rs651907 0.535 rs13059470 chr3:101424800 A/G cg12386194 chr3:101231763 SENP7 -0.46 -9.78 -0.36 3.95e-21 Colorectal cancer; BRCA cis rs654950 1.000 rs646228 chr1:41986066 A/C cg06885757 chr1:42089581 HIVEP3 0.29 9.74 0.36 5.43e-21 Airway imaging phenotypes; BRCA trans rs3808502 0.516 rs6983727 chr8:11415812 A/G cg06636001 chr8:8085503 FLJ10661 0.55 11.5 0.41 6.27e-28 Neuroticism; BRCA cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg06092702 chr1:163392909 NA -0.37 -9.77 -0.36 4.34e-21 Motion sickness; BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg13047869 chr3:10149882 C3orf24 0.6 12.93 0.46 3.76e-34 Alzheimer's disease; BRCA cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg06115741 chr20:33292138 TP53INP2 -0.37 -7.92 -0.3 1.09e-14 Glomerular filtration rate (creatinine); BRCA cis rs6772849 0.896 rs35535737 chr3:128383406 G/A cg16766828 chr3:128327626 NA -0.39 -8.63 -0.32 4.91e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs7666738 0.830 rs28417716 chr4:98864859 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs9858542 0.537 rs34915642 chr3:49358646 G/A cg00383909 chr3:49044727 WDR6 0.45 9.64 0.36 1.3e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs67981189 0.896 rs2526878 chr14:71377295 A/G cg15816911 chr14:71606274 NA -0.37 -8.21 -0.31 1.27e-15 Schizophrenia; BRCA cis rs2576037 0.583 rs9954336 chr18:44465945 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.59 0.5 7.57e-42 Personality dimensions; BRCA cis rs1003719 0.582 rs2835634 chr21:38528270 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.41e-41 Eye color traits; BRCA cis rs6547741 1.000 rs4666009 chr2:27857992 T/A cg27432699 chr2:27873401 GPN1 0.45 9.34 0.35 1.51e-19 Oral cavity cancer; BRCA cis rs17270561 0.666 rs3923725 chr6:25734920 C/A cg16482183 chr6:26056742 HIST1H1C 0.5 9.41 0.35 8.9e-20 Iron status biomarkers; BRCA cis rs758324 0.648 rs31474 chr5:131405027 A/G cg06307176 chr5:131281290 NA -0.36 -7.83 -0.3 2.06e-14 Alzheimer's disease in APOE e4- carriers; BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg04944784 chr2:26401820 FAM59B 1.01 16.64 0.55 6.66e-52 Gut microbiome composition (summer); BRCA cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg14983838 chr19:29218262 NA 0.54 10.08 0.37 2.78e-22 Methadone dose in opioid dependence; BRCA cis rs7552404 1.000 rs4949872 chr1:76131392 C/G cg22875332 chr1:76189707 ACADM 0.69 14.56 0.5 1.11e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg12386194 chr3:101231763 SENP7 0.46 9.7 0.36 7.74e-21 Colorectal cancer; BRCA cis rs57221529 0.709 rs4957056 chr5:570105 T/C cg20362242 chr5:692897 TPPP 0.52 8.34 0.31 4.5e-16 Lung disease severity in cystic fibrosis; BRCA trans rs2204008 0.840 rs7957966 chr12:37953629 A/G cg06521331 chr12:34319734 NA 0.44 8.54 0.32 9.75e-17 Bladder cancer; BRCA cis rs67478160 0.634 rs941475 chr14:104240618 A/C cg08213375 chr14:104286397 PPP1R13B 0.57 14.86 0.51 4.16e-43 Schizophrenia; BRCA cis rs4664304 0.658 rs2667012 chr2:160867553 G/T cg14819504 chr2:160761413 LY75 -0.33 -8.09 -0.3 2.98e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7191700 0.511 rs243330 chr16:11350991 C/T cg00044050 chr16:11439710 C16orf75 0.38 9.04 0.34 1.86e-18 Multiple sclerosis; BRCA cis rs8141529 0.748 rs5762882 chr22:29290680 C/A cg02153584 chr22:29168773 CCDC117 0.52 10.83 0.39 3.42e-25 Lymphocyte counts; BRCA trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg00717180 chr2:96193071 NA -0.4 -11.14 -0.4 1.88e-26 Coronary artery disease; BRCA cis rs3858526 1.000 rs10838909 chr11:5960490 G/A cg05234568 chr11:5960015 NA -0.5 -10.25 -0.38 6.48e-23 DNA methylation (variation); BRCA cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.59 0.55 1.2e-51 Colonoscopy-negative controls vs population controls; BRCA trans rs9325144 0.560 rs12424821 chr12:38649951 C/T cg23762105 chr12:34175262 ALG10 0.34 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs9311474 0.508 rs17052256 chr3:52593119 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.56 -0.32 8.48e-17 Electroencephalogram traits; BRCA cis rs1400816 0.850 rs2037164 chr2:172542238 C/T cg13550731 chr2:172543902 DYNC1I2 0.54 8.48 0.32 1.56e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs17401966 0.838 rs61775885 chr1:10281445 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.75 0.48 7.09e-38 Hepatocellular carcinoma; BRCA cis rs3761847 0.622 rs10818500 chr9:123810883 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.38 -7.92 -0.3 1.07e-14 Rheumatoid arthritis; BRCA cis rs752010 0.695 rs12134166 chr1:42105867 C/T cg06885757 chr1:42089581 HIVEP3 0.23 8.35 0.31 4.34e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs72781680 0.752 rs72780185 chr2:24003967 G/A cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs11190604 1.000 rs2495750 chr10:102327708 A/G cg07080220 chr10:102295463 HIF1AN 0.56 12.4 0.44 8.58e-32 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9325144 0.505 rs10785560 chr12:38636622 C/T cg26384229 chr12:38710491 ALG10B 0.61 15.44 0.52 6.46e-46 Morning vs. evening chronotype; BRCA cis rs10499694 0.933 rs11575334 chr7:50597301 G/A cg18232548 chr7:50535776 DDC -0.39 -9.41 -0.35 9.06e-20 Body mass index; BRCA cis rs7666738 0.791 rs11735105 chr4:98937357 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6088813 0.961 rs6088791 chr20:33907909 A/G cg14752227 chr20:34000481 UQCC 0.4 8.38 0.31 3.45e-16 Height; BRCA cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg00321850 chr1:175162397 KIAA0040 0.43 12.31 0.44 2.06e-31 Alcohol dependence; BRCA trans rs35110281 0.622 rs9977258 chr21:44976485 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.5 10.79 0.39 4.67e-25 Mean corpuscular volume; BRCA trans rs1005277 0.579 rs1780122 chr10:38529509 C/A cg23533926 chr12:111358616 MYL2 -0.43 -8.94 -0.33 4.09e-18 Extrinsic epigenetic age acceleration; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg12669354 chr11:831584 CD151;EFCAB4A -0.37 -8.01 -0.3 5.36e-15 Mean platelet volume; BRCA cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg24642439 chr20:33292090 TP53INP2 -0.43 -8.7 -0.33 2.89e-17 Height; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg21747090 chr2:27597821 SNX17 -0.4 -8.76 -0.33 1.76e-17 Total body bone mineral density; BRCA cis rs79839061 0.518 rs11734537 chr4:869174 A/G cg07828340 chr4:882639 GAK 1.04 12.39 0.44 9.94e-32 Intelligence (multi-trait analysis); BRCA cis rs3741151 0.773 rs17244596 chr11:73179236 A/G cg17517138 chr11:73019481 ARHGEF17 0.87 12.43 0.44 6.12e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg11764359 chr7:65958608 NA 0.59 12.93 0.46 3.82e-34 Aortic root size; BRCA cis rs586533 0.793 rs680485 chr11:99502078 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.13 0.31 2.29e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2288073 0.965 rs36101491 chr2:24387532 C/T cg26838691 chr2:24397539 C2orf84 -0.53 -9.25 -0.34 3.38e-19 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs79490411 chr1:46813568 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.1 0.34 1.11e-18 Menopause (age at onset); BRCA trans rs853679 0.882 rs9366717 chr6:28191057 C/T cg01620082 chr3:125678407 NA -0.59 -8.24 -0.31 1.01e-15 Depression; BRCA cis rs6456156 0.692 rs9457270 chr6:167512928 A/G cg07741184 chr6:167504864 NA 0.39 11.17 0.4 1.4e-26 Primary biliary cholangitis; BRCA cis rs13046373 0.535 rs1354866 chr21:31981559 A/T cg24082983 chr21:31802169 KRTAP13-4 0.33 8.45 0.32 2.02e-16 HDL cholesterol; BRCA cis rs2832191 0.791 rs2832198 chr21:30498240 C/T cg08807101 chr21:30365312 RNF160 0.6 15.07 0.51 3.86e-44 Dental caries; BRCA cis rs13046373 0.535 rs7281767 chr21:32022062 T/C cg06468780 chr21:31798236 KRTAP13-3 0.33 8.37 0.31 3.62e-16 HDL cholesterol; BRCA trans rs2204008 0.837 rs12146734 chr12:38237079 A/G cg06521331 chr12:34319734 NA -0.49 -9.11 -0.34 1.06e-18 Bladder cancer; BRCA cis rs7524258 0.868 rs916393 chr1:7272250 T/C cg07173049 chr1:7289937 CAMTA1 0.48 11.73 0.42 6.79e-29 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg03709012 chr19:19516395 GATAD2A -0.74 -16.48 -0.55 4.07e-51 Tonsillectomy; BRCA cis rs11249608 0.548 rs11951738 chr5:178491228 G/A cg21905437 chr5:178450457 ZNF879 0.49 9.51 0.35 3.81e-20 Pubertal anthropometrics; BRCA cis rs6831352 0.838 rs2851250 chr4:100044113 G/C cg13256891 chr4:100009986 ADH5 0.52 9.67 0.36 1e-20 Alcohol dependence; BRCA cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1065852 0.526 rs56234624 chr22:42388826 A/G cg22189786 chr22:42395067 WBP2NL 0.41 8.17 0.31 1.69e-15 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA trans rs877282 0.891 rs12357999 chr10:796468 A/C cg22713356 chr15:30763199 NA 1.41 28.52 0.75 5.26e-116 Uric acid levels; BRCA cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.0 -0.4 6.78e-26 Extrinsic epigenetic age acceleration; BRCA cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg24562669 chr7:97807699 LMTK2 -0.61 -18.1 -0.58 1.94e-59 Breast cancer; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg18279126 chr7:2041391 MAD1L1 0.4 8.79 0.33 1.39e-17 Bipolar disorder and schizophrenia; BRCA trans rs2739330 0.796 rs2154594 chr22:24254055 A/G cg06437703 chr8:37914619 EIF4EBP1 0.33 8.8 0.33 1.3e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6743226 0.901 rs7599888 chr2:242248033 C/G cg10021735 chr2:242295487 FARP2 -0.39 -10.63 -0.39 2.04e-24 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs6866344 0.697 rs62392823 chr5:178126968 T/C cg10224037 chr5:178157518 ZNF354A 0.76 16.01 0.54 9.58e-49 Neutrophil percentage of white cells; BRCA cis rs7493 1.000 rs7493 chr7:95034775 C/G cg19678392 chr7:94953810 PON1 0.43 9.4 0.35 9.53e-20 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs61931739 0.500 rs11053290 chr12:34582392 C/T cg13010199 chr12:38710504 ALG10B -0.43 -9.14 -0.34 8.07e-19 Morning vs. evening chronotype; BRCA cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg21573476 chr21:45109991 RRP1B -0.36 -9.05 -0.34 1.65e-18 Mean corpuscular volume; BRCA trans rs9929218 0.954 rs2059254 chr16:68817439 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -0.65 -13.49 -0.47 1.11e-36 Colorectal cancer; BRCA cis rs738322 1.000 rs738322 chr22:38569006 A/G cg25457927 chr22:38595422 NA -0.33 -12.28 -0.44 2.73e-31 Cutaneous nevi; BRCA cis rs796364 1.000 rs796364 chr2:200716119 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.72 12.09 0.43 1.98e-30 Schizophrenia; BRCA cis rs8031584 0.958 rs35256769 chr15:31237776 G/A cg08109568 chr15:31115862 NA -0.45 -10.66 -0.39 1.62e-24 Huntington's disease progression; BRCA cis rs3858526 0.959 rs10838901 chr11:5959128 G/A cg13902645 chr11:5959945 NA -0.54 -11.27 -0.41 5.35e-27 DNA methylation (variation); BRCA cis rs10752881 0.905 rs10797830 chr1:183036274 A/T ch.1.3577855R chr1:183094577 LAMC1 0.65 16.93 0.56 2.25e-53 Colorectal cancer; BRCA cis rs9470366 0.816 rs7774130 chr6:36623756 C/T cg08179530 chr6:36648295 CDKN1A 0.51 10.29 0.38 4.51e-23 QRS duration; BRCA cis rs1059312 0.808 rs11059921 chr12:129289919 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.78 -19.83 -0.62 1.4e-68 Systemic lupus erythematosus; BRCA cis rs4919087 0.926 rs2861875 chr10:98990139 C/G cg25902810 chr10:99078978 FRAT1 -0.43 -9.23 -0.34 4.03e-19 Monocyte count; BRCA cis rs9811920 0.535 rs704571 chr3:99481946 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.41 -9.67 -0.36 9.66e-21 Axial length; BRCA cis rs8177253 1.000 rs1525892 chr3:133484712 C/T cg11941060 chr3:133502564 NA -0.5 -12.17 -0.43 8.81e-31 Iron status biomarkers; BRCA cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg20790798 chr5:1857306 NA -0.4 -9.39 -0.35 1.04e-19 Cardiovascular disease risk factors; BRCA cis rs6963495 0.818 rs55794529 chr7:105165747 T/C cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA trans rs561341 0.783 rs512698 chr17:30292507 G/T cg20587970 chr11:113659929 NA -1.2 -22.06 -0.66 1.33e-80 Hip circumference adjusted for BMI; BRCA cis rs9341808 0.754 rs3793000 chr6:80995137 G/A cg08355045 chr6:80787529 NA 0.36 9.21 0.34 4.75e-19 Sitting height ratio; BRCA cis rs11229555 0.645 rs7929868 chr11:58209418 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs8114671 0.967 rs2069948 chr20:33762489 C/T cg07148914 chr20:33460835 GGT7 0.38 8.03 0.3 4.77e-15 Height; BRCA cis rs4665809 1.000 rs10182857 chr2:26344411 C/T cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs4363385 0.747 rs6678107 chr1:152966818 T/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.53 -0.35 3.12e-20 Inflammatory skin disease; BRCA trans rs66573146 0.831 rs6851488 chr4:6987412 C/T cg07817883 chr1:32538562 TMEM39B 1.05 16.03 0.54 7.14e-49 Granulocyte percentage of myeloid white cells; BRCA cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg11189052 chr15:85197271 WDR73 -0.42 -8.45 -0.32 1.99e-16 Schizophrenia; BRCA cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg16405210 chr4:1374714 KIAA1530 0.36 8.06 0.3 3.81e-15 Obesity-related traits; BRCA cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg07537917 chr2:241836409 C2orf54 -0.48 -11.34 -0.41 2.83e-27 Urinary metabolites; BRCA cis rs561341 1.000 rs554078 chr17:30330109 A/C cg23018236 chr17:30244563 NA -0.68 -10.57 -0.39 3.45e-24 Hip circumference adjusted for BMI; BRCA cis rs2882667 0.858 rs11242442 chr5:138380489 C/T cg04439458 chr5:138467593 SIL1 -0.43 -10.72 -0.39 8.66e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4642101 0.737 rs4447735 chr3:12825513 C/T cg24848339 chr3:12840334 CAND2 0.47 12.31 0.44 2.2e-31 QRS complex (12-leadsum); BRCA cis rs372883 0.648 rs1153291 chr21:30689070 G/T cg08807101 chr21:30365312 RNF160 -0.38 -8.33 -0.31 4.94e-16 Pancreatic cancer; BRCA cis rs4808199 0.948 rs12982276 chr19:19459800 T/C cg01262667 chr19:19385393 TM6SF2 0.41 8.94 0.33 4.01e-18 Nonalcoholic fatty liver disease; BRCA cis rs9811920 0.609 rs9872871 chr3:99658702 C/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.38 -7.82 -0.3 2.13e-14 Axial length; BRCA cis rs3815700 1.000 rs8104328 chr19:33094371 G/A cg02997394 chr19:33096574 ANKRD27 0.69 11.53 0.41 4.63e-28 Eosinophilic esophagitis; BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg09263875 chr16:632152 PIGQ 0.73 21.29 0.64 2.12e-76 Height; BRCA cis rs8103278 1.000 rs8102876 chr19:46332842 C/T cg14061069 chr19:46274453 DMPK -0.48 -11.63 -0.42 1.79e-28 Coronary artery disease; BRCA cis rs7568458 0.684 rs7608074 chr2:85809703 T/G cg02493740 chr2:85810744 VAMP5 -0.56 -11.58 -0.42 2.88e-28 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs10782582 0.609 rs1796810 chr1:76403305 C/T cg03433033 chr1:76189801 ACADM -0.4 -8.42 -0.32 2.57e-16 Daytime sleep phenotypes; BRCA cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg11057378 chr10:81107060 PPIF 0.41 9.89 0.36 1.42e-21 Height; BRCA cis rs3768617 0.510 rs1413390 chr1:183096634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs10193935 1.000 rs12618105 chr2:42414146 T/G cg27598129 chr2:42591480 NA -0.94 -15.03 -0.51 6.18e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs6942756 0.806 rs7788327 chr7:128986519 C/T cg02491457 chr7:128862824 NA -0.58 -12.43 -0.44 6.63e-32 White matter hyperintensity burden; BRCA cis rs2832191 0.967 rs2898160 chr21:30487496 A/G cg24692254 chr21:30365293 RNF160 -0.59 -15.06 -0.51 4.21e-44 Dental caries; BRCA trans rs3857536 0.776 rs9294687 chr6:66942919 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs9443645 0.901 rs4415132 chr6:79554107 T/C cg18132916 chr6:79620363 NA -0.5 -11.42 -0.41 1.28e-27 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.748 rs7312204 chr12:38334909 T/C cg06521331 chr12:34319734 NA -0.48 -9.24 -0.34 3.75e-19 Bladder cancer; BRCA cis rs3096299 0.719 rs2965817 chr16:89513234 C/T cg08822215 chr16:89438651 ANKRD11 -0.4 -8.48 -0.32 1.53e-16 Multiple myeloma (IgH translocation); BRCA trans rs3733585 0.673 rs4580649 chr4:9948461 G/A cg26043149 chr18:55253948 FECH -0.37 -8.02 -0.3 5.17e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg18904891 chr8:8559673 CLDN23 0.65 12.91 0.45 4.83e-34 Obesity-related traits; BRCA trans rs2562456 0.917 rs2650793 chr19:21676115 C/G cg25042112 chr7:64838748 ZNF92 0.41 8.03 0.3 4.68e-15 Pain; BRCA cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg27129171 chr3:47204927 SETD2 -0.71 -16.95 -0.56 1.78e-53 Colorectal cancer; BRCA cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg07952391 chr2:88470173 THNSL2 0.67 9.26 0.34 2.98e-19 Plasma clusterin levels; BRCA cis rs7737355 0.947 rs9885286 chr5:130883270 C/T cg06307176 chr5:131281290 NA 0.54 10.79 0.39 4.78e-25 Life satisfaction; BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg27170947 chr2:26402098 FAM59B -0.66 -11.24 -0.41 7.23e-27 Gut microbiome composition (summer); BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg18402987 chr7:1209562 NA 0.76 11.58 0.42 2.67e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs11678157 chr2:26321526 T/C cg27170947 chr2:26402098 FAM59B -0.64 -11.31 -0.41 3.51e-27 Gut microbiome composition (summer); BRCA cis rs7953508 0.506 rs768775 chr12:93968197 T/C cg18151635 chr12:93972918 NA -0.46 -9.19 -0.34 5.6e-19 Pubertal anthropometrics; BRCA cis rs7666738 0.830 rs2865989 chr4:99067532 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.34 -0.35 1.6e-19 Alzheimer's disease (late onset); BRCA cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2742234 0.541 rs1879310 chr10:43734775 A/G cg15436174 chr10:43711423 RASGEF1A 0.5 10.05 0.37 3.62e-22 Hirschsprung disease; BRCA cis rs10911232 0.507 rs10797832 chr1:183044034 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.54 0.55 1.98e-51 Hypertriglyceridemia; BRCA cis rs2836974 0.623 rs7280326 chr21:40700408 A/G cg06238570 chr21:40685208 BRWD1 -0.45 -8.95 -0.33 3.77e-18 Cognitive function; BRCA cis rs7011049 1.000 rs72640868 chr8:53843812 C/A cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg13770153 chr20:60521292 NA 0.56 11.81 0.42 2.89e-29 Body mass index; BRCA cis rs10751667 0.714 rs7395879 chr11:963855 G/C ch.11.42038R chr11:967971 AP2A2 0.52 16.62 0.55 8.25e-52 Alzheimer's disease (late onset); BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.58 -0.39 3.38e-24 Lymphocyte counts; BRCA cis rs4819052 0.655 rs2330102 chr21:46690968 C/G cg11663144 chr21:46675770 NA -0.47 -11.04 -0.4 4.77e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg23708337 chr7:1209742 NA 0.43 8.19 0.31 1.4e-15 Longevity;Endometriosis; BRCA cis rs11229555 0.874 rs10896788 chr11:58292976 G/A cg15696309 chr11:58395628 NA -0.53 -11.38 -0.41 1.83e-27 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs523522 0.962 rs2393590 chr12:120913900 G/A cg12219531 chr12:120966889 COQ5 0.53 11.13 0.4 2.04e-26 High light scatter reticulocyte count; BRCA cis rs4727027 0.727 rs3801980 chr7:148878620 T/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.46 10.26 0.38 5.58e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs654351 0.541 rs556554 chr6:10388774 T/C cg04978078 chr6:10383147 NA -0.43 -8.33 -0.31 4.83e-16 Squamous cell lung carcinoma; BRCA cis rs7927771 1.000 rs1317149 chr11:47486885 C/T cg18512352 chr11:47633146 NA -0.38 -9.23 -0.34 3.81e-19 Subjective well-being; BRCA cis rs1023500 0.505 rs134874 chr22:42661144 A/G cg15557168 chr22:42548783 NA -0.32 -8.9 -0.33 5.6e-18 Schizophrenia; BRCA cis rs10501293 1.000 rs2862694 chr11:43064753 C/T cg03447554 chr11:43094025 NA 0.49 9.08 0.34 1.31e-18 Cognitive performance; BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg09060608 chr5:178986726 RUFY1 0.54 13.11 0.46 5.75e-35 Lung cancer; BRCA cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg00750074 chr16:89608354 SPG7 -0.33 -8.78 -0.33 1.5e-17 Multiple myeloma (IgH translocation); BRCA cis rs1348850 0.914 rs7591807 chr2:178252986 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.91 0.37 1.19e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs12541635 0.902 rs13277300 chr8:107062819 C/T cg10147462 chr8:107024639 NA -0.34 -9.48 -0.35 4.96e-20 Age of smoking initiation; BRCA cis rs77633900 0.614 rs280029 chr15:77031235 A/G cg21673338 chr15:77095150 SCAPER -0.53 -9.43 -0.35 7.28e-20 Non-glioblastoma glioma;Glioma; BRCA cis rs10782582 0.593 rs2147039 chr1:76143166 C/T cg03433033 chr1:76189801 ACADM -0.46 -9.6 -0.35 1.8e-20 Daytime sleep phenotypes; BRCA cis rs7267979 1.000 rs4813563 chr20:25365340 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.12 -0.34 9.31e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9467773 1.000 rs3736781 chr6:26505362 G/A cg11502198 chr6:26597334 ABT1 0.47 9.48 0.35 4.75e-20 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs397119 chr20:25440187 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.97 0.33 3.29e-18 Liver enzyme levels (alkaline phosphatase); BRCA trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg20587970 chr11:113659929 NA -1.35 -23.98 -0.69 3.91e-91 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.830 rs6854902 chr4:99033416 T/G cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6714710 0.603 rs2305143 chr2:98413781 C/T cg26665480 chr2:98280029 ACTR1B 0.58 13.61 0.47 3.28e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1153858 1.000 rs4625670 chr15:45652926 C/T cg21132104 chr15:45694354 SPATA5L1 0.75 17.09 0.56 3.4e-54 Homoarginine levels; BRCA cis rs9287719 0.967 rs6432119 chr2:10753687 A/T cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs41005 1.000 rs13402078 chr2:8113107 C/T cg03155496 chr2:8117019 LOC339788 -0.57 -15.06 -0.51 4.35e-44 Response to anti-TNF therapy in rheumatoid arthritis; BRCA trans rs7824557 0.767 rs6985460 chr8:11171087 A/C cg06636001 chr8:8085503 FLJ10661 0.51 9.86 0.36 1.98e-21 Retinal vascular caliber; BRCA cis rs3820928 0.874 rs55959848 chr2:227805426 C/A cg11843606 chr2:227700838 RHBDD1 -0.41 -9.04 -0.34 1.9e-18 Pulmonary function; BRCA cis rs514406 0.929 rs555741 chr1:53318851 T/G cg16325326 chr1:53192061 ZYG11B 0.69 17.45 0.57 4.78e-56 Monocyte count; BRCA cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg08754478 chr10:133766260 PPP2R2D -0.67 -13.67 -0.48 1.7e-37 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2882667 0.690 rs6884198 chr5:138164307 C/T cg04439458 chr5:138467593 SIL1 0.31 7.81 0.3 2.28e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9527 0.615 rs10883800 chr10:104671212 A/C cg04362960 chr10:104952993 NT5C2 0.45 10.36 0.38 2.38e-23 Arsenic metabolism; BRCA cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.45 8.65 0.32 4.32e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs2016266 0.859 rs7953656 chr12:53738433 G/T cg26875137 chr12:53738046 NA 0.46 11.99 0.43 4.97e-30 Bone mineral density (spine);Bone mineral density; BRCA cis rs1451375 0.617 rs9942686 chr7:50596381 G/A cg18232548 chr7:50535776 DDC 0.44 9.28 0.34 2.67e-19 Malaria; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg05279229 chr7:1896384 MAD1L1 -0.42 -7.98 -0.3 6.56e-15 Bipolar disorder and schizophrenia; BRCA cis rs4780401 0.609 rs55934118 chr16:11820003 G/C cg01061890 chr16:11836724 TXNDC11 -0.56 -13.35 -0.47 5.15e-36 Rheumatoid arthritis; BRCA cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg06766960 chr11:133703094 NA -0.62 -12.87 -0.45 7.37e-34 Childhood ear infection; BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg26314531 chr2:26401878 FAM59B 0.95 16.42 0.54 8.01e-51 Gut microbiome composition (summer); BRCA cis rs2304069 0.954 rs10045945 chr5:149419297 C/T cg12661370 chr5:149340060 SLC26A2 0.54 8.01 0.3 5.46e-15 HIV-1 control; BRCA cis rs798554 0.567 rs1182190 chr7:2869391 A/G cg09658497 chr7:2847517 GNA12 -0.39 -8.07 -0.3 3.47e-15 Height; BRCA cis rs1506636 0.646 rs805789 chr7:123221920 G/T cg03229431 chr7:123269106 ASB15 -0.6 -12.81 -0.45 1.32e-33 Plateletcrit;Platelet count; BRCA cis rs7945718 0.967 rs1440286 chr11:12809152 G/A cg25843174 chr11:12811716 TEAD1 0.23 8.84 0.33 9.5e-18 Educational attainment (years of education); BRCA cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.38 -8.07 -0.3 3.61e-15 Alzheimer's disease (late onset); BRCA cis rs35110281 0.667 rs4819285 chr21:45118970 C/T cg01579765 chr21:45077557 HSF2BP 0.41 11.41 0.41 1.43e-27 Mean corpuscular volume; BRCA trans rs9409565 0.826 rs9409546 chr9:97209066 T/C cg05679027 chr9:99775184 HIATL2 -0.43 -9.47 -0.35 5.15e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs7781557 0.938 rs73192015 chr7:102511732 C/T cg18108683 chr7:102477205 FBXL13 -0.4 -8.02 -0.3 5.22e-15 Colorectal adenoma (advanced); BRCA cis rs7592578 0.599 rs62180992 chr2:191285732 A/G cg10560079 chr2:191398806 TMEM194B -0.67 -11.49 -0.41 6.35e-28 Diastolic blood pressure; BRCA cis rs2836974 0.666 rs4624474 chr21:40686327 T/C cg22974920 chr21:40686053 BRWD1 -0.4 -8.76 -0.33 1.73e-17 Cognitive function; BRCA cis rs7267979 0.934 rs6037085 chr20:25305202 C/T cg08601574 chr20:25228251 PYGB -0.36 -8.6 -0.32 6.12e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6570726 0.935 rs432086 chr6:145841593 C/T cg23711669 chr6:146136114 FBXO30 -0.63 -14.67 -0.5 3.46e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs4076764 0.914 rs12123378 chr1:163377846 C/T cg24596788 chr1:163392923 NA -0.41 -10.92 -0.4 1.4e-25 Motion sickness; BRCA cis rs3845702 0.736 rs2678936 chr2:180872179 G/C cg01881094 chr2:180872142 CWC22 1.04 18.93 0.6 8.75e-64 Schizophrenia; BRCA cis rs514406 0.929 rs564273 chr1:53332445 G/C cg24675658 chr1:53192096 ZYG11B -0.53 -11.32 -0.41 3.28e-27 Monocyte count; BRCA cis rs10504229 0.953 rs57669205 chr8:58172253 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs34330 0.562 rs11055023 chr12:12853197 A/G cg09462578 chr12:12878428 APOLD1 -0.67 -11.55 -0.42 3.77e-28 Systemic lupus erythematosus; BRCA cis rs11605275 1.000 rs78091560 chr11:20032279 G/A cg14835545 chr11:20032148 NAV2 -0.59 -9.36 -0.35 1.28e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg11266682 chr4:10021025 SLC2A9 0.38 9.74 0.36 5.56e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg00750074 chr16:89608354 SPG7 -0.41 -10.93 -0.4 1.28e-25 Multiple myeloma (IgH translocation); BRCA cis rs12210905 0.688 rs12215353 chr6:27407022 C/T cg08851530 chr6:28072375 NA 0.81 7.89 0.3 1.3e-14 Hip circumference adjusted for BMI; BRCA cis rs34330 0.562 rs12229100 chr12:12865836 A/G cg09462578 chr12:12878428 APOLD1 0.7 12.18 0.43 8.01e-31 Systemic lupus erythematosus; BRCA cis rs11190604 1.000 rs57025426 chr10:102205868 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.18 0.4 1.28e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs11250464 0.755 rs11250468 chr10:1410060 A/G cg08668359 chr10:1443807 ADARB2 0.49 9.46 0.35 5.91e-20 Radiation response; BRCA cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs9790314 1.000 rs1382426 chr3:161045933 G/A cg04691961 chr3:161091175 C3orf57 -0.59 -14.04 -0.49 3.32e-39 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg24829409 chr8:58192753 C8orf71 -0.59 -12.3 -0.44 2.45e-31 Developmental language disorder (linguistic errors); BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 10.69 0.39 1.17e-24 Platelet count; BRCA cis rs1832871 0.965 rs861179 chr6:158712720 A/G cg07215822 chr6:158701037 NA -0.43 -7.83 -0.3 1.97e-14 Height; BRCA cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg02187348 chr16:89574699 SPG7 0.47 11.14 0.4 1.9e-26 Multiple myeloma (IgH translocation); BRCA cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg17294928 chr15:75287854 SCAMP5 0.71 15.14 0.51 1.82e-44 Blood trace element (Zn levels); BRCA cis rs7586879 0.687 rs11892869 chr2:25096692 A/T cg04586622 chr2:25135609 ADCY3 0.42 10.61 0.39 2.39e-24 Body mass index; BRCA cis rs10504229 1.000 rs57186557 chr8:58177277 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7264396 0.563 rs2425130 chr20:34335059 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.91 -0.43 1.13e-29 Total cholesterol levels; BRCA cis rs769267 1.000 rs769267 chr19:19446936 A/G cg01262667 chr19:19385393 TM6SF2 0.4 10.38 0.38 1.98e-23 Tonsillectomy; BRCA cis rs495337 0.720 rs2869937 chr20:48536618 C/G cg17835207 chr20:48524531 SPATA2 -0.69 -16.83 -0.55 7.01e-53 Psoriasis; BRCA cis rs2070488 1.000 rs6772046 chr3:38479660 C/T cg24069376 chr3:38537580 EXOG 0.4 11.52 0.41 4.95e-28 Electrocardiographic conduction measures; BRCA cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs950776 0.593 rs481134 chr15:78877563 C/T cg06917634 chr15:78832804 PSMA4 0.6 13.27 0.46 1.1e-35 Sudden cardiac arrest; BRCA cis rs875971 0.928 rs2036263 chr7:65800197 C/T cg11764359 chr7:65958608 NA -0.77 -17.73 -0.57 1.71e-57 Aortic root size; BRCA cis rs13064411 0.518 rs9842559 chr3:113252705 A/C cg18753928 chr3:113234510 CCDC52 -0.41 -9.09 -0.34 1.2e-18 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.47e-61 Cognitive function; BRCA cis rs7666738 0.830 rs13112037 chr4:98976986 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs3617 0.573 rs12638968 chr3:52919447 T/A cg11645453 chr3:52864694 ITIH4 -0.36 -9.53 -0.35 3.31e-20 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs778371 0.748 rs2675953 chr2:233749565 G/C cg08000102 chr2:233561755 GIGYF2 -0.77 -16.82 -0.55 8.09e-53 Schizophrenia; BRCA cis rs10267417 0.603 rs10258555 chr7:19868344 T/G cg07541023 chr7:19748670 TWISTNB 0.51 9.25 0.34 3.23e-19 Night sleep phenotypes; BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.08 0.34 1.39e-18 Tonsillectomy; BRCA cis rs208520 0.754 rs1100989 chr6:66880532 G/A cg07460842 chr6:66804631 NA -0.98 -18.46 -0.59 2.69e-61 Exhaled nitric oxide output; BRCA cis rs9790314 0.905 rs7613358 chr3:160949296 T/C cg04691961 chr3:161091175 C3orf57 -0.44 -10.68 -0.39 1.3e-24 Morning vs. evening chronotype; BRCA cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14240646 chr10:27532245 ACBD5 -0.6 -9.96 -0.37 8.38e-22 Breast cancer; BRCA cis rs1008375 0.932 rs13134570 chr4:17692863 C/T cg15017067 chr4:17643749 FAM184B -0.27 -8.1 -0.31 2.82e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg08085267 chr17:45401833 C17orf57 -0.6 -12.11 -0.43 1.48e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7178424 0.875 rs7172967 chr15:62218568 A/C cg00456672 chr15:62358751 C2CD4A 0.37 8.39 0.31 3.17e-16 Height; BRCA cis rs8177253 0.965 rs4854760 chr3:133498741 C/T cg16414030 chr3:133502952 NA 0.44 10.66 0.39 1.51e-24 Iron status biomarkers; BRCA cis rs9427116 0.502 rs9426829 chr1:154592201 T/C cg17218026 chr1:154582156 ADAR 0.28 8.23 0.31 1.05e-15 Blood protein levels; BRCA cis rs875971 0.638 rs801205 chr7:66022144 C/A cg11764359 chr7:65958608 NA -0.68 -15.19 -0.52 9.74e-45 Aortic root size; BRCA trans rs61931739 0.517 rs10844802 chr12:34231001 C/A cg13010199 chr12:38710504 ALG10B 0.49 9.58 0.35 2.14e-20 Morning vs. evening chronotype; BRCA cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg01483505 chr11:975446 AP2A2 0.31 8.31 0.31 5.63e-16 Alzheimer's disease (late onset); BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg24082983 chr21:31802169 KRTAP13-4 0.34 8.54 0.32 9.67e-17 HDL cholesterol; BRCA cis rs57590327 0.503 rs11706976 chr3:81899653 C/T cg07356753 chr3:81810745 GBE1 -0.44 -10.06 -0.37 3.41e-22 Extraversion; BRCA cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs7707921 0.752 rs34981833 chr5:81272732 T/C cg15871215 chr5:81402204 ATG10 -0.39 -8.21 -0.31 1.22e-15 Breast cancer; BRCA cis rs12618769 0.520 rs4851135 chr2:99050705 T/A cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.62e-15 Bipolar disorder; BRCA cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11890956 chr21:40555474 PSMG1 -0.62 -13.8 -0.48 4.27e-38 Menarche (age at onset); BRCA cis rs6433895 0.677 rs6716261 chr2:182031232 A/C cg00481216 chr2:181971175 NA 0.41 7.82 0.3 2.13e-14 Lymphocyte counts; BRCA cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg04317338 chr11:64019027 PLCB3 0.55 9.5 0.35 4.22e-20 Mean platelet volume; BRCA cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg04518342 chr5:131593106 PDLIM4 0.35 8.83 0.33 9.94e-18 Breast cancer; BRCA cis rs698833 0.886 rs786613 chr2:44590066 C/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.6 -12.54 -0.44 2.2e-32 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4664304 0.966 rs925407 chr2:160767502 A/C cg14819504 chr2:160761413 LY75 -0.4 -9.87 -0.36 1.76e-21 Crohn's disease;Inflammatory bowel disease; BRCA cis rs798554 0.704 rs798531 chr7:2770067 G/C cg19717773 chr7:2847554 GNA12 -0.42 -9.01 -0.34 2.3e-18 Height; BRCA cis rs2764980 1.000 rs2764978 chr10:3283385 C/G cg18054281 chr10:3284093 NA -0.31 -7.86 -0.3 1.6e-14 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs2658782 0.724 rs2658770 chr11:93261886 A/G cg15737290 chr11:93063684 CCDC67 0.47 9.1 0.34 1.12e-18 Pulmonary function decline; BRCA cis rs6963495 0.818 rs6973974 chr7:105170629 C/T cg19920283 chr7:105172520 RINT1 0.59 9.53 0.35 3.29e-20 Bipolar disorder (body mass index interaction); BRCA trans rs3960554 0.808 rs2286829 chr7:75677739 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 12.53 0.44 2.26e-32 Eotaxin levels; BRCA cis rs17401966 0.931 rs34225619 chr1:10371987 C/T cg03954927 chr1:10346856 KIF1B 0.45 13.15 0.46 4e-35 Hepatocellular carcinoma; BRCA trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg11707556 chr5:10655725 ANKRD33B 0.44 9.97 0.37 7.29e-22 Coronary artery disease; BRCA cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg05868516 chr6:26286170 HIST1H4H 0.41 7.96 0.3 7.79e-15 Educational attainment; BRCA cis rs6570726 0.791 rs12208812 chr6:145900924 T/G cg13319975 chr6:146136371 FBXO30 -0.4 -9.15 -0.34 7.47e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs12579753 0.913 rs12579018 chr12:82231943 T/C cg07988820 chr12:82153109 PPFIA2 -0.65 -10.43 -0.38 1.32e-23 Resting heart rate; BRCA cis rs5758659 0.652 rs133330 chr22:42409456 G/A cg15557168 chr22:42548783 NA -0.31 -8.58 -0.32 7.15e-17 Cognitive function; BRCA cis rs12200782 0.530 rs9379892 chr6:26582414 G/A cg11502198 chr6:26597334 ABT1 0.61 9.44 0.35 6.79e-20 Small cell lung carcinoma; BRCA trans rs61931739 0.892 rs61931711 chr12:34045374 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.38 -0.35 1.09e-19 Morning vs. evening chronotype; BRCA cis rs6430585 0.583 rs3769012 chr2:136556480 C/T cg07169764 chr2:136633963 MCM6 1.32 32.0 0.78 8.09e-135 Corneal structure; BRCA trans rs61931739 0.534 rs11052991 chr12:34059018 G/T cg13010199 chr12:38710504 ALG10B -0.4 -8.07 -0.3 3.56e-15 Morning vs. evening chronotype; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg23285459 chr7:2802560 GNA12 -0.35 -8.75 -0.33 1.86e-17 Height; BRCA cis rs2832191 0.636 rs8131283 chr21:30516796 A/G cg08807101 chr21:30365312 RNF160 -0.44 -9.36 -0.35 1.36e-19 Dental caries; BRCA cis rs16958440 1.000 rs2289132 chr18:44602292 G/A cg17192377 chr18:44677553 HDHD2 0.65 9.52 0.35 3.37e-20 Sitting height ratio; BRCA cis rs7917772 0.604 rs7908249 chr10:104373300 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.31 0.49 1.79e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9325144 0.560 rs2387924 chr12:38662883 A/G cg26384229 chr12:38710491 ALG10B -0.5 -13.14 -0.46 4.29e-35 Morning vs. evening chronotype; BRCA cis rs12413816 0.963 rs12359348 chr10:13765950 C/T cg16485048 chr10:13749193 FRMD4A -0.56 -13.48 -0.47 1.31e-36 Red cell distribution width; BRCA cis rs7177699 0.525 rs7402376 chr15:79113570 A/G cg00540400 chr15:79124168 NA -0.28 -7.83 -0.3 2.06e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs7520050 0.898 rs4660885 chr1:46243756 C/T cg24296786 chr1:45957014 TESK2 0.44 10.16 0.37 1.37e-22 Red blood cell count;Reticulocyte count; BRCA cis rs2016266 0.859 rs10747668 chr12:53737461 C/T cg26875137 chr12:53738046 NA 0.46 11.81 0.42 2.87e-29 Bone mineral density (spine);Bone mineral density; BRCA cis rs2070488 0.804 rs13092539 chr3:38458725 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.01 0.56 8.21e-54 Electrocardiographic conduction measures; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.06 -0.43 2.49e-30 Alzheimer's disease; BRCA cis rs8062405 1.000 rs61737565 chr16:28855522 G/C cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.4e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1707322 1.000 rs10890382 chr1:46469674 A/G cg03146154 chr1:46216737 IPP 0.48 10.52 0.38 5.71e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg11890956 chr21:40555474 PSMG1 -0.58 -12.66 -0.45 6.22e-33 Menarche (age at onset); BRCA cis rs7552167 0.925 rs4489498 chr1:24512055 A/G cg01960748 chr1:24522592 NA 0.59 10.69 0.39 1.23e-24 Psoriasis vulgaris; BRCA cis rs2032447 0.839 rs6901039 chr6:26000885 A/C cg03264133 chr6:25882463 NA -0.43 -9.2 -0.34 5.09e-19 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs4711094 chr6:25706174 T/A cg17691542 chr6:26056736 HIST1H1C 0.43 8.35 0.31 4.1e-16 Iron status biomarkers; BRCA cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg12927641 chr6:109611667 NA 0.42 10.93 0.4 1.28e-25 Reticulocyte fraction of red cells; BRCA cis rs72772090 0.634 rs72773906 chr5:96092274 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -13.46 -0.47 1.57e-36 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs780096 0.546 rs715326 chr2:27725761 A/G cg21747090 chr2:27597821 SNX17 0.38 8.23 0.31 1.03e-15 Total body bone mineral density; BRCA cis rs782590 0.967 rs782586 chr2:55836165 A/C cg18811423 chr2:55921094 PNPT1 0.73 23.12 0.67 1.97e-86 Metabolic syndrome; BRCA cis rs3733585 0.699 rs4621431 chr4:9947590 C/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.3 -0.38 4.13e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.68 0.36 9.22e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9467773 1.000 rs6940053 chr6:26562122 C/T cg11502198 chr6:26597334 ABT1 0.48 9.67 0.36 1.01e-20 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.766 rs6848 chr5:140086062 A/T cg11822812 chr5:140052017 DND1 -0.32 -8.72 -0.33 2.43e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs6088580 0.505 rs6141503 chr20:33274469 G/A cg07148914 chr20:33460835 GGT7 -0.36 -7.85 -0.3 1.8e-14 Glomerular filtration rate (creatinine); BRCA cis rs701145 0.585 rs1542254 chr3:153864296 C/T cg17054900 chr3:154042577 DHX36 0.44 8.09 0.3 2.93e-15 Coronary artery disease; BRCA cis rs875971 0.862 rs778734 chr7:65814849 C/G cg11764359 chr7:65958608 NA 0.76 17.49 0.57 2.79e-56 Aortic root size; BRCA cis rs2439831 0.702 rs28699233 chr15:44122866 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.6 9.66 0.36 1.03e-20 Lung cancer in ever smokers; BRCA cis rs2559856 1.000 rs2695298 chr12:102082589 G/A cg12924262 chr12:102091054 CHPT1 0.36 8.13 0.31 2.22e-15 Blood protein levels; BRCA cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg27478167 chr7:817139 HEATR2 0.54 10.48 0.38 7.72e-24 Cerebrospinal P-tau181p levels; BRCA cis rs1008375 0.897 rs67455495 chr4:17665238 A/T cg15017067 chr4:17643749 FAM184B -0.27 -7.99 -0.3 6.5e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs870825 0.616 rs57316663 chr4:185630011 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.28 0.56 3.69e-55 Blood protein levels; BRCA trans rs2204008 0.805 rs4589389 chr12:37946120 C/A cg06521331 chr12:34319734 NA 0.43 8.4 0.32 2.86e-16 Bladder cancer; BRCA cis rs17253792 0.545 rs12879564 chr14:56017694 A/G cg01858014 chr14:56050164 KTN1 -0.61 -7.95 -0.3 8.3e-15 Putamen volume; BRCA cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg18305652 chr10:134549665 INPP5A 0.49 11.17 0.4 1.39e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.2 0.54 9.97e-50 Morning vs. evening chronotype; BRCA cis rs116095464 0.558 rs9312978 chr5:221930 C/G cg22857025 chr5:266934 NA -1.03 -20.11 -0.62 4.43e-70 Breast cancer; BRCA cis rs7267979 1.000 rs7018 chr20:25278261 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.3 0.35 2.25e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4730250 0.654 rs12705405 chr7:106792517 C/T cg02696742 chr7:106810147 HBP1 0.57 9.43 0.35 7.51e-20 Osteoarthritis; BRCA cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.08e-24 Motion sickness; BRCA cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg10802521 chr3:52805072 NEK4 -0.34 -9.22 -0.34 4.31e-19 Electroencephalogram traits; BRCA cis rs11605275 1.000 rs11603592 chr11:20023522 C/T cg14835545 chr11:20032148 NAV2 -0.6 -8.97 -0.33 3.22e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs875971 0.862 rs11769079 chr7:65842128 G/A cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA cis rs2243480 1.000 rs1723269 chr7:65472786 C/G cg18252515 chr7:66147081 NA -0.91 -12.95 -0.46 3.02e-34 Diabetic kidney disease; BRCA trans rs6600671 1.000 rs10903159 chr1:121181997 G/T cg17023122 chr1:144479586 NA 0.33 7.85 0.3 1.71e-14 Hip geometry; BRCA cis rs4268898 0.662 rs2303292 chr2:24432138 C/T cg06627628 chr2:24431161 ITSN2 -0.85 -15.66 -0.53 5.08e-47 Asthma; BRCA cis rs7903847 0.642 rs7084654 chr10:99135262 G/A cg20016023 chr10:99160130 RRP12 -0.27 -8.67 -0.32 3.59e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs798554 0.704 rs798503 chr7:2789704 G/A cg09658497 chr7:2847517 GNA12 -0.39 -8.03 -0.3 4.85e-15 Height; BRCA trans rs7746199 0.736 rs13212093 chr6:27606716 C/T cg06606381 chr12:133084897 FBRSL1 -0.86 -8.5 -0.32 1.38e-16 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA trans rs12517041 1.000 rs10057246 chr5:23294721 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs11105298 0.786 rs3803128 chr12:89860319 C/A cg00757033 chr12:89920650 WDR51B 0.53 10.71 0.39 1.02e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs12545109 0.879 rs1975285 chr8:57358682 G/C cg09654669 chr8:57350985 NA -0.43 -8.13 -0.31 2.2e-15 Obesity-related traits; BRCA cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg27398817 chr8:82754497 SNX16 -0.44 -8.57 -0.32 7.59e-17 Diastolic blood pressure; BRCA cis rs751728 0.643 rs12173787 chr6:33735471 G/C cg25922239 chr6:33757077 LEMD2 0.37 8.75 0.33 1.85e-17 Crohn's disease; BRCA cis rs7666738 0.830 rs35491210 chr4:99003364 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.65 0.55 5.99e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs490234 0.719 rs13287525 chr9:128219180 T/C cg14078157 chr9:128172775 NA -0.39 -8.93 -0.33 4.65e-18 Mean arterial pressure; BRCA cis rs9296092 0.538 rs80012910 chr6:33519542 G/A cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs72781680 0.821 rs72796378 chr2:24167385 G/A cg08917208 chr2:24149416 ATAD2B 0.64 10.79 0.39 4.83e-25 Lymphocyte counts; BRCA cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs9463078 0.764 rs10948194 chr6:44951990 A/C cg25276700 chr6:44698697 NA -0.37 -8.53 -0.32 1.02e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg17845761 chr1:175162550 KIAA0040 -0.26 -9.91 -0.37 1.23e-21 Alcohol dependence; BRCA cis rs6582630 0.555 rs11181684 chr12:38388000 T/C cg13010199 chr12:38710504 ALG10B 0.45 9.31 0.35 2.04e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.753 rs1830230 chr4:99026186 G/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.77e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.639 rs2291764 chr8:58142943 A/C cg20607798 chr8:58055168 NA 0.59 8.94 0.33 4.21e-18 Developmental language disorder (linguistic errors); BRCA cis rs6933660 0.745 rs9371517 chr6:151739810 G/T cg14262678 chr6:151773367 RMND1;C6orf211 0.48 11.36 0.41 2.28e-27 Menarche (age at onset); BRCA cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06544989 chr22:39130855 UNC84B -0.33 -7.89 -0.3 1.36e-14 Menopause (age at onset); BRCA cis rs2066819 1.000 rs78495928 chr12:56635080 G/C cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs9309711 0.922 rs13431788 chr2:3482912 G/A cg10845886 chr2:3471009 TTC15 -0.81 -17.81 -0.58 6.52e-58 Neurofibrillary tangles; BRCA trans rs61931739 0.591 rs10743834 chr12:33916129 A/C cg26384229 chr12:38710491 ALG10B 0.39 8.91 0.33 5.5e-18 Morning vs. evening chronotype; BRCA cis rs1005277 0.505 rs200910 chr10:38108176 C/T cg00409905 chr10:38381863 ZNF37A -0.48 -10.46 -0.38 9.62e-24 Extrinsic epigenetic age acceleration; BRCA cis rs12579753 0.917 rs10778833 chr12:82197983 G/T cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs4363385 0.703 rs4845517 chr1:153003893 T/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.96 -0.33 3.53e-18 Inflammatory skin disease; BRCA trans rs7395662 0.736 rs4882036 chr11:48749384 A/G cg00717180 chr2:96193071 NA -0.32 -8.7 -0.33 2.76e-17 HDL cholesterol; BRCA cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg02544614 chr20:61657117 NA 0.28 8.13 0.31 2.22e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs6089829 0.925 rs13041507 chr20:61666180 T/C cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9733 0.519 rs10788792 chr1:150638572 T/G cg17724175 chr1:150552817 MCL1 0.26 8.52 0.32 1.12e-16 Tonsillectomy; BRCA cis rs9291683 0.704 rs11726271 chr4:10098192 G/A cg11266682 chr4:10021025 SLC2A9 -0.41 -10.88 -0.4 2.11e-25 Bone mineral density; BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg25036284 chr2:26402008 FAM59B -0.64 -10.99 -0.4 7.42e-26 Gut microbiome composition (summer); BRCA cis rs936229 0.768 rs936226 chr15:75069282 C/T cg14664628 chr15:75095509 CSK -0.93 -26.31 -0.72 6.27e-104 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.95 0.37 8.73e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9287719 0.904 rs55738250 chr2:10757132 G/A cg00105475 chr2:10696890 NA 0.44 10.3 0.38 4.11e-23 Prostate cancer; BRCA cis rs7811142 0.830 rs11771936 chr7:99943283 A/G cg00814883 chr7:100076585 TSC22D4 -0.49 -9.95 -0.37 8.76e-22 Platelet count; BRCA cis rs2180341 0.814 rs6919277 chr6:127738050 T/C cg24812749 chr6:127587940 RNF146 0.68 15.39 0.52 1.1e-45 Breast cancer; BRCA cis rs3733585 0.781 rs13103690 chr4:9972778 T/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.18 -0.37 1.15e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs60843830 1.000 rs62114501 chr2:231741 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.34 0.59 1.18e-60 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg24110177 chr3:50126178 RBM5 -0.36 -9.85 -0.36 2.05e-21 Intelligence (multi-trait analysis); BRCA cis rs6484504 0.625 rs7940420 chr11:31366700 T/A cg14844989 chr11:31128820 NA 0.45 9.55 0.35 2.74e-20 Red blood cell count; BRCA cis rs7520050 0.966 rs785495 chr1:46587887 A/G cg24296786 chr1:45957014 TESK2 0.43 9.73 0.36 5.64e-21 Red blood cell count;Reticulocyte count; BRCA cis rs13191362 1.000 rs35820211 chr6:163046252 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.0 15.21 0.52 8.07e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg24562669 chr7:97807699 LMTK2 0.47 11.85 0.42 2.05e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7945718 0.839 rs11022512 chr11:12835952 G/A cg25843174 chr11:12811716 TEAD1 0.22 8.51 0.32 1.23e-16 Educational attainment (years of education); BRCA cis rs897984 0.568 rs8050107 chr16:30893451 C/T cg02466173 chr16:30829666 NA 0.44 8.77 0.33 1.64e-17 Dementia with Lewy bodies; BRCA cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg26769984 chr7:1090371 C7orf50 -0.61 -10.98 -0.4 8.42e-26 Bronchopulmonary dysplasia; BRCA cis rs36052053 0.908 rs34739891 chr6:109611467 C/G cg12927641 chr6:109611667 NA -0.52 -7.81 -0.3 2.38e-14 Red cell distribution width; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg16590910 chr6:42928470 GNMT 0.43 9.61 0.36 1.61e-20 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6840360 0.571 rs4696275 chr4:152530981 C/T cg22705602 chr4:152727874 NA -0.33 -8.26 -0.31 8.67e-16 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.78e-14 Tonsillectomy; BRCA cis rs6580649 1.000 rs10783227 chr12:48400617 C/T cg24011408 chr12:48396354 COL2A1 0.55 9.35 0.35 1.5e-19 Lung cancer; BRCA cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg01028140 chr2:1542097 TPO -0.72 -13.82 -0.48 3.5e-38 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs778371 0.578 rs2675956 chr2:233753340 G/A cg08000102 chr2:233561755 GIGYF2 -0.64 -14.28 -0.49 2.42e-40 Schizophrenia; BRCA cis rs1707322 1.000 rs11211236 chr1:46443767 C/A cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2075371 1.000 rs7486 chr7:133975183 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.53 0.47 7.36e-37 Mean platelet volume; BRCA cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11644478 chr21:40555479 PSMG1 0.84 19.75 0.62 4.13e-68 Cognitive function; BRCA trans rs6479891 1.000 rs4747045 chr10:64926482 C/T cg14819942 chr15:35414228 NA 0.35 8.59 0.32 6.6e-17 Arthritis (juvenile idiopathic); BRCA cis rs514406 0.679 rs12563825 chr1:53238324 G/T cg27535305 chr1:53392650 SCP2 0.46 10.6 0.39 2.78e-24 Monocyte count; BRCA cis rs589448 0.902 rs315134 chr12:69762713 G/A cg14784868 chr12:69753453 YEATS4 0.78 25.08 0.7 3.65e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs7493 0.901 rs17883318 chr7:94958312 G/A cg17330251 chr7:94953956 PON1 -0.37 -8.0 -0.3 5.82e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs113835537 0.529 rs11824771 chr11:66262550 T/C cg24851651 chr11:66362959 CCS 0.42 8.08 0.3 3.16e-15 Airway imaging phenotypes; BRCA cis rs2953174 0.720 rs2975794 chr2:241515813 C/T cg07929629 chr2:241523174 NA 0.49 8.81 0.33 1.18e-17 Bipolar disorder; BRCA cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Alcohol dependence; BRCA cis rs1008375 0.931 rs6837181 chr4:17701253 A/C cg16339924 chr4:17578868 LAP3 0.57 13.82 0.48 3.54e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 0.863 rs1552095 chr4:120460306 A/G cg25214090 chr10:38739885 LOC399744 0.57 12.38 0.44 1e-31 Corneal astigmatism; BRCA cis rs67478160 0.643 rs8005594 chr14:104279889 T/C cg08213375 chr14:104286397 PPP1R13B 0.65 18.67 0.59 2.17e-62 Schizophrenia; BRCA cis rs477692 0.699 rs471390 chr10:131382825 A/G cg24747557 chr10:131355152 MGMT 0.38 9.52 0.35 3.64e-20 Response to temozolomide; BRCA cis rs6842047 0.809 rs3087505 chr4:187179486 A/G cg02012338 chr4:187126139 CYP4V2 0.81 8.99 0.33 2.87e-18 Blood protein levels; BRCA cis rs2836974 0.526 rs418359 chr21:40536734 T/C cg22974920 chr21:40686053 BRWD1 -0.38 -8.64 -0.32 4.6e-17 Cognitive function; BRCA cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg11608241 chr8:8085544 FLJ10661 -0.32 -8.99 -0.34 2.69e-18 Mood instability; BRCA cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg24531977 chr5:56204891 C5orf35 -1.06 -22.83 -0.67 8.61e-85 Initial pursuit acceleration; BRCA cis rs6752107 0.967 rs3816234 chr2:234185999 G/A cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.39 0.41 1.73e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs2070488 0.965 rs1046048 chr3:38524742 C/T cg24069376 chr3:38537580 EXOG 0.42 12.03 0.43 3.52e-30 Electrocardiographic conduction measures; BRCA cis rs3733585 0.699 rs13328050 chr4:9951120 G/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.46 -0.38 9.45e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg18301423 chr5:131593218 PDLIM4 0.35 8.75 0.33 1.93e-17 Acylcarnitine levels; BRCA cis rs2576037 0.526 rs607780 chr18:44417456 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.88 0.43 1.51e-29 Personality dimensions; BRCA cis rs2204008 0.728 rs11495375 chr12:38282631 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.11 0.37 2.19e-22 Bladder cancer; BRCA cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg23895963 chr12:117471115 NA -0.53 -9.62 -0.36 1.52e-20 Subcortical brain region volumes;Hippocampal volume; BRCA trans rs35110281 0.687 rs4819284 chr21:45084548 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.37 7.94 0.3 8.81e-15 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.09e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg01448562 chr3:133502909 NA 0.36 8.19 0.31 1.46e-15 Alcohol consumption (transferrin glycosylation); BRCA trans rs11098499 0.863 rs3775841 chr4:120425777 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.02 0.3 5.1e-15 Corneal astigmatism; BRCA trans rs11989744 0.597 rs2033788 chr8:23574847 G/T cg03492747 chr16:86543808 FOXF1 -0.41 -10.01 -0.37 5.14e-22 Waist-hip ratio; BRCA cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 4.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 1.000 rs13271966 chr8:8575472 T/C cg18904891 chr8:8559673 CLDN23 0.59 11.56 0.42 3.28e-28 Obesity-related traits; BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg20607798 chr8:58055168 NA 0.59 8.96 0.33 3.59e-18 Developmental language disorder (linguistic errors); BRCA cis rs73086581 1.000 rs17287822 chr20:3978536 C/T cg02187196 chr20:3869020 PANK2 0.5 9.02 0.34 2.18e-18 Response to antidepressants in depression; BRCA cis rs12431939 1.000 rs34063246 chr14:51663719 G/C cg23942311 chr14:51606299 NA -0.43 -8.04 -0.3 4.35e-15 Cancer; BRCA trans rs7939886 0.920 rs11227273 chr11:55893034 T/G cg15704280 chr7:45808275 SEPT13 0.61 7.83 0.3 1.98e-14 Myopia (pathological); BRCA cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg26031613 chr14:104095156 KLC1 -0.55 -9.79 -0.36 3.57e-21 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs1577917 0.696 rs10806334 chr6:86439329 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -8.91 -0.33 5.43e-18 Response to antipsychotic treatment; BRCA cis rs10870270 1.000 rs7077744 chr10:133770201 C/T cg08754478 chr10:133766260 PPP2R2D -0.69 -14.16 -0.49 8.86e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 10.01 0.37 5.23e-22 Tonsillectomy; BRCA trans rs7615952 0.599 rs7652883 chr3:125707977 T/G cg07211511 chr3:129823064 LOC729375 -0.62 -11.18 -0.4 1.21e-26 Blood pressure (smoking interaction); BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.02 0.3 4.9e-15 Tonsillectomy; BRCA cis rs6793245 0.810 rs1805126 chr3:38592406 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.37 8.35 0.31 4.08e-16 QT interval; BRCA cis rs9831754 0.654 rs9837024 chr3:78451637 C/T cg06138941 chr3:78371609 NA 0.57 12.17 0.43 8.79e-31 Calcium levels; BRCA cis rs1865760 0.963 rs9356991 chr6:25901758 C/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.37 0.38 2.13e-23 Height; BRCA cis rs2991971 0.776 rs12139364 chr1:45890155 T/C cg15605315 chr1:45957053 TESK2 0.45 8.86 0.33 8.08e-18 High light scatter reticulocyte count; BRCA cis rs5997397 0.934 rs6005864 chr22:29157487 A/G cg15103426 chr22:29168792 CCDC117 -0.48 -12.03 -0.43 3.5e-30 Red cell distribution width; BRCA cis rs10751667 0.857 rs6597961 chr11:976677 T/C ch.11.42038R chr11:967971 AP2A2 0.58 18.86 0.6 2.09e-63 Alzheimer's disease (late onset); BRCA cis rs11955398 0.678 rs12522801 chr5:59978406 A/G cg02684056 chr5:59996105 DEPDC1B 0.39 9.34 0.35 1.5700000000000001e-19 Intelligence (multi-trait analysis); BRCA cis rs7246657 1.000 rs1823061 chr19:37800626 G/A cg14683738 chr19:37701593 ZNF585B 0.5 8.48 0.32 1.57e-16 Coronary artery calcification; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg08470875 chr2:26401718 FAM59B 0.71 11.44 0.41 1.02e-27 Gut microbiome composition (summer); BRCA cis rs9393777 0.513 rs9348728 chr6:26634436 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.67 -0.32 3.58e-17 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.714 rs175319 chr6:25956172 A/G cg03517284 chr6:25882590 NA -0.55 -11.2 -0.41 1.03e-26 Intelligence (multi-trait analysis); BRCA cis rs35146811 0.771 rs6465762 chr7:99620554 G/A cg22906224 chr7:99728672 NA 0.46 8.75 0.33 1.9e-17 Coronary artery disease; BRCA cis rs7618915 1.000 rs3852064 chr3:52349412 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 8.14 0.31 2.07e-15 Bipolar disorder; BRCA cis rs6430585 0.583 rs12475516 chr2:136560761 C/G cg07169764 chr2:136633963 MCM6 1.01 22.6 0.67 1.49e-83 Corneal structure; BRCA trans rs561341 0.941 rs17780086 chr17:30343282 G/A cg20587970 chr11:113659929 NA -1.37 -24.14 -0.69 5.33e-92 Hip circumference adjusted for BMI; BRCA cis rs9790314 0.639 rs6769642 chr3:160763469 C/A cg04691961 chr3:161091175 C3orf57 -0.41 -8.58 -0.32 7.35e-17 Morning vs. evening chronotype; BRCA cis rs7582180 0.652 rs11694700 chr2:100936637 C/T cg14675211 chr2:100938903 LONRF2 0.52 12.09 0.43 1.87e-30 Intelligence (multi-trait analysis); BRCA cis rs858239 0.669 rs6461687 chr7:23116580 A/G cg23682824 chr7:23144976 KLHL7 0.34 8.71 0.33 2.67e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs7103648 0.618 rs11039284 chr11:47564785 A/G cg20307385 chr11:47447363 PSMC3 0.76 16.73 0.55 2.31e-52 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1577917 0.771 rs6454486 chr6:86433587 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.31 8.54 0.32 9.87e-17 Response to antipsychotic treatment; BRCA trans rs7618501 0.633 rs2252833 chr3:50004209 C/T cg21659725 chr3:3221576 CRBN 0.44 10.83 0.39 3.15e-25 Intelligence (multi-trait analysis); BRCA cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg11301795 chr4:187892539 NA -0.31 -10.27 -0.38 5.22e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs12618769 0.597 rs2278206 chr2:99172244 A/G cg10123293 chr2:99228465 UNC50 0.42 8.44 0.32 2.1e-16 Bipolar disorder; BRCA cis rs2243480 1.000 rs778691 chr7:65873092 G/C cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs765787 0.530 rs12592055 chr15:45514477 C/T cg25801113 chr15:45476975 SHF -0.32 -7.97 -0.3 7.13e-15 Uric acid levels; BRCA cis rs9814567 1.000 rs7433991 chr3:134312292 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg07256732 chr16:621771 PIGQ -0.35 -9.53 -0.35 3.18e-20 Height; BRCA cis rs2645694 0.626 rs2703136 chr4:77828957 T/A cg18351406 chr4:77819688 ANKRD56 0.58 12.65 0.45 6.65e-33 Emphysema distribution in smoking; BRCA cis rs9814567 1.000 rs13081688 chr3:134259954 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.95e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg02951883 chr7:2050386 MAD1L1 -0.51 -12.67 -0.45 5.43e-33 Bipolar disorder and schizophrenia; BRCA cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg24110177 chr3:50126178 RBM5 0.44 11.27 0.41 5.27e-27 Intelligence (multi-trait analysis); BRCA cis rs60871478 0.947 rs62432239 chr7:794576 C/T cg27478167 chr7:817139 HEATR2 -0.41 -8.97 -0.33 3.24e-18 Cerebrospinal P-tau181p levels; BRCA trans rs9325144 0.560 rs11182930 chr12:38633693 A/T cg23762105 chr12:34175262 ALG10 0.34 7.84 0.3 1.83e-14 Morning vs. evening chronotype; BRCA cis rs13095912 1.000 rs34965813 chr3:185333012 T/C cg11274856 chr3:185301563 NA 0.34 8.45 0.32 1.9e-16 Systolic blood pressure; BRCA cis rs769267 0.929 rs2905421 chr19:19457908 G/T cg02546618 chr19:19431379 KIAA0892;SF4 0.37 8.72 0.33 2.32e-17 Tonsillectomy; BRCA cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg17971929 chr21:40555470 PSMG1 0.79 18.53 0.59 1.18e-61 Cognitive function; BRCA cis rs2688608 0.592 rs7909544 chr10:75484004 G/C cg23231163 chr10:75533350 FUT11 -0.34 -8.89 -0.33 6e-18 Inflammatory bowel disease; BRCA cis rs6964587 0.692 rs6970629 chr7:91846599 T/C cg17063962 chr7:91808500 NA 0.57 13.11 0.46 6.29e-35 Breast cancer; BRCA trans rs911555 0.755 rs1116095 chr14:103931879 A/G cg17675199 chr6:35436792 RPL10A -0.3 -8.21 -0.31 1.2e-15 Intelligence (multi-trait analysis); BRCA cis rs8014204 0.869 rs2070599 chr14:75361177 C/G cg06637938 chr14:75390232 RPS6KL1 -0.57 -11.68 -0.42 1.01e-28 Caffeine consumption; BRCA cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg19077165 chr18:44547161 KATNAL2 -0.51 -11.01 -0.4 6.12e-26 Personality dimensions; BRCA cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg19748678 chr4:122722346 EXOSC9 0.72 15.64 0.53 6.71e-47 Type 2 diabetes; BRCA cis rs870825 0.655 rs67380800 chr4:185623788 T/C cg04058563 chr4:185651563 MLF1IP 0.77 16.89 0.56 3.35e-53 Blood protein levels; BRCA cis rs12142240 0.698 rs41294458 chr1:46810304 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs13108904 0.967 rs1732107 chr4:1276758 G/A cg05665937 chr4:1216051 CTBP1 -0.37 -7.85 -0.3 1.71e-14 Obesity-related traits; BRCA cis rs1401999 0.674 rs562 chr3:183637845 T/C cg20387954 chr3:183756860 HTR3D 0.35 8.18 0.31 1.49e-15 Anterior chamber depth; BRCA cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg01884057 chr2:25150051 NA 0.33 8.24 0.31 9.61e-16 Body mass index; BRCA cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.51 -11.26 -0.41 5.77e-27 Colorectal cancer; BRCA cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg02297831 chr4:17616191 MED28 0.36 8.33 0.31 4.96e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.59 -12.31 -0.44 2.1e-31 Lymphocyte counts; BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg25036284 chr2:26402008 FAM59B -0.87 -15.81 -0.53 9.3e-48 Gut microbiome composition (summer); BRCA cis rs30380 0.553 rs152280 chr5:96161942 T/G cg16492584 chr5:96139282 ERAP1 -0.44 -10.05 -0.37 3.83e-22 Cerebrospinal fluid biomarker levels; BRCA cis rs2832077 0.943 rs2832097 chr21:30173340 A/T cg24692254 chr21:30365293 RNF160 0.43 7.86 0.3 1.66e-14 Cognitive test performance; BRCA cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg05084668 chr3:125655381 ALG1L -0.47 -8.09 -0.3 2.91e-15 Blood pressure (smoking interaction); BRCA cis rs1215050 0.740 rs1084777 chr4:99017542 C/T cg05340658 chr4:99064831 C4orf37 -0.48 -11.16 -0.4 1.59e-26 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2012796 0.956 rs7147254 chr14:81820503 G/A cg02996355 chr14:81879375 NA 0.51 9.98 0.37 6.92e-22 Night sleep phenotypes; BRCA cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg18904891 chr8:8559673 CLDN23 0.65 12.97 0.46 2.56e-34 Obesity-related traits; BRCA cis rs8072100 0.837 rs8070463 chr17:45768836 A/G cg08085267 chr17:45401833 C17orf57 -0.56 -11.56 -0.42 3.47e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4363385 0.818 rs454993 chr1:153008992 C/G cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg18404041 chr3:52824283 ITIH1 -0.52 -16.3 -0.54 3.41e-50 Bipolar disorder; BRCA cis rs4363385 0.747 rs6704105 chr1:152964397 C/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.56 -0.35 2.58e-20 Inflammatory skin disease; BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.57 -11.9 -0.43 1.26e-29 Lymphocyte counts; BRCA cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg03161606 chr19:29218774 NA 0.46 8.11 0.31 2.56e-15 Methadone dose in opioid dependence; BRCA cis rs7520050 0.778 rs2934857 chr1:46039612 A/G cg24296786 chr1:45957014 TESK2 -0.49 -11.66 -0.42 1.33e-28 Red blood cell count;Reticulocyte count; BRCA cis rs2404602 0.563 rs12914005 chr15:76765667 A/G cg22467129 chr15:76604101 ETFA -0.49 -10.63 -0.39 2.11e-24 Blood metabolite levels; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.17e-19 Total body bone mineral density; BRCA cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.81 -0.36 2.89e-21 Developmental language disorder (linguistic errors); BRCA cis rs10746514 0.833 rs2026302 chr1:232264047 A/G cg09506761 chr1:232265262 NA -0.42 -8.77 -0.33 1.57e-17 Response to statin therapy; BRCA cis rs6088590 1.000 rs6119516 chr20:33328024 C/T cg06115741 chr20:33292138 TP53INP2 0.5 11.11 0.4 2.47e-26 Coronary artery disease; BRCA cis rs12479064 0.703 rs28382977 chr2:100018304 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.53 -11.28 -0.41 4.79e-27 Chronic sinus infection; BRCA cis rs1401999 1.000 rs1401999 chr3:183678342 C/G cg20387954 chr3:183756860 HTR3D 0.45 10.03 0.37 4.19e-22 Anterior chamber depth; BRCA cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.98 -0.33 3.08e-18 Alzheimer's disease (late onset); BRCA cis rs10751667 0.666 rs7396677 chr11:958878 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.6 0.55 9.93e-52 Alzheimer's disease (late onset); BRCA cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg02734326 chr4:10020555 SLC2A9 0.35 7.83 0.3 2.07e-14 Bone mineral density; BRCA cis rs3733346 0.553 rs6813110 chr4:942660 C/T cg08222618 chr4:941054 TMEM175 0.4 9.4 0.35 9.62e-20 Sjögren's syndrome; BRCA trans rs783540 0.900 rs783525 chr15:83284629 T/A cg18393722 chr15:85113863 UBE2QP1 -0.28 -8.9 -0.33 5.85e-18 Schizophrenia; BRCA cis rs4074536 0.536 rs6687961 chr1:116289824 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs6952808 0.782 rs4236271 chr7:1881369 C/T cg03354898 chr7:1950403 MAD1L1 -0.46 -10.07 -0.37 3.04e-22 Bipolar disorder and schizophrenia; BRCA cis rs11577318 1.000 rs11577318 chr1:26601570 A/G cg04990556 chr1:26633338 UBXN11 0.52 8.73 0.33 2.14e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7818345 0.904 rs6997164 chr8:19287856 G/T cg11303988 chr8:19266685 CSGALNACT1 0.3 7.9 0.3 1.18e-14 Language performance in older adults (adjusted for episodic memory); BRCA cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 20.17 0.62 2.26e-70 Smoking behavior; BRCA cis rs7945705 0.714 rs2653570 chr11:8987823 A/G cg12365402 chr11:9010492 NRIP3 -0.44 -10.4 -0.38 1.66e-23 Hemoglobin concentration; BRCA cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg21770322 chr7:97807741 LMTK2 0.46 11.9 0.43 1.23e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs829883 0.738 rs249854 chr12:98862772 G/A cg25150519 chr12:98850993 NA 0.68 16.4 0.54 1.01e-50 Colorectal adenoma (advanced); BRCA cis rs10256972 0.685 rs10263665 chr7:1110628 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.36 -8.03 -0.3 4.71e-15 Longevity;Endometriosis; BRCA cis rs9399135 0.935 rs4273704 chr6:135297520 G/T cg24558204 chr6:135376177 HBS1L 0.46 12.59 0.45 1.23e-32 Red blood cell count; BRCA cis rs3806843 1.000 rs7701755 chr5:140182101 G/T cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.83 -0.36 2.54e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs10754283 0.870 rs2390764 chr1:90112827 T/G cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs8077889 0.871 rs7212648 chr17:41917962 A/C cg26893861 chr17:41843967 DUSP3 0.69 13.23 0.46 1.74e-35 Triglycerides; BRCA cis rs4285028 0.699 rs6771068 chr3:121478745 A/T cg01951420 chr3:121553821 IQCB1;EAF2 0.76 14.29 0.49 2.12e-40 Multiple sclerosis; BRCA cis rs9788682 0.694 rs10851906 chr15:78774676 A/G cg24631222 chr15:78858424 CHRNA5 0.49 9.49 0.35 4.6e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg15485101 chr11:133734466 NA 0.41 9.76 0.36 4.46e-21 Childhood ear infection; BRCA cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg26248373 chr2:1572462 NA -0.66 -15.48 -0.52 3.7e-46 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7246657 0.714 rs12972195 chr19:37752505 T/C cg18154014 chr19:37997991 ZNF793 0.47 8.78 0.33 1.45e-17 Coronary artery calcification; BRCA cis rs7927771 0.965 rs1064608 chr11:47640429 G/C cg18512352 chr11:47633146 NA -0.38 -9.1 -0.34 1.1e-18 Subjective well-being; BRCA cis rs1552244 0.882 rs61429272 chr3:10037320 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.69 0.55 3.7e-52 Alzheimer's disease; BRCA cis rs74417235 0.684 rs13179358 chr5:154059746 C/A cg07371521 chr5:154026371 NA 0.42 8.13 0.31 2.25e-15 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg08885076 chr2:99613938 TSGA10 -0.6 -13.41 -0.47 2.63e-36 Chronic sinus infection; BRCA cis rs1209950 0.966 rs1209948 chr21:40170078 C/T cg01359822 chr21:40176597 ETS2 0.34 8.51 0.32 1.24e-16 Non-small cell lung cancer (survival); BRCA cis rs17376456 0.825 rs13161885 chr5:93071242 A/C cg21475434 chr5:93447410 FAM172A 0.67 8.65 0.32 4.14e-17 Diabetic retinopathy; BRCA cis rs7715811 1.000 rs7446025 chr5:13773800 T/A cg07548982 chr5:13769939 DNAH5 -0.41 -9.06 -0.34 1.57e-18 Subclinical atherosclerosis traits (other); BRCA cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg23711669 chr6:146136114 FBXO30 -0.78 -18.78 -0.6 5.47e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs8180040 0.726 rs4078466 chr3:47126543 C/T cg27129171 chr3:47204927 SETD2 0.76 19.31 0.61 8.16e-66 Colorectal cancer; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg07256732 chr16:621771 PIGQ -0.35 -9.21 -0.34 4.54e-19 Height; BRCA cis rs1008375 1.000 rs1006722 chr4:17618713 A/G cg04450456 chr4:17643702 FAM184B -0.35 -9.98 -0.37 7.06e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17270561 0.636 rs6456697 chr6:25741434 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs651907 1.000 rs651907 chr3:101600724 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.35 8.21 0.31 1.19e-15 Colorectal cancer; BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.85e-20 Tonsillectomy; BRCA cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg26149184 chr10:133730230 NA 0.39 7.89 0.3 1.35e-14 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs13191362 0.872 rs13215538 chr6:163037975 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.53 8.26 0.31 8.43e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7560272 0.538 rs13014700 chr2:73920121 C/G cg20560298 chr2:73613845 ALMS1 0.35 9.18 0.34 5.74e-19 Schizophrenia; BRCA cis rs3820928 0.874 rs10166736 chr2:227900419 C/T cg11843606 chr2:227700838 RHBDD1 -0.35 -7.88 -0.3 1.45e-14 Pulmonary function; BRCA cis rs2070488 0.965 rs1065800 chr3:38566480 C/T cg24069376 chr3:38537580 EXOG -0.42 -11.85 -0.42 2.11e-29 Electrocardiographic conduction measures; BRCA cis rs2276314 0.857 rs9304155 chr18:33585710 A/C cg05985134 chr18:33552581 C18orf21 0.65 12.36 0.44 1.25e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7552404 0.924 rs7550974 chr1:76204185 A/G cg10523679 chr1:76189770 ACADM 0.91 22.35 0.66 3.42e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.791 rs12233867 chr4:98950233 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.39 0.38 1.77e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6089584 0.528 rs4925335 chr20:60627034 G/A cg06108461 chr20:60628389 TAF4 -0.73 -15.3 -0.52 3e-45 Body mass index; BRCA cis rs9549367 0.789 rs12584813 chr13:113895443 C/G cg00898013 chr13:113819073 PROZ -0.35 -8.61 -0.32 5.77e-17 Platelet distribution width; BRCA cis rs922182 0.595 rs9302232 chr15:64205358 C/T cg24729988 chr15:64271149 DAPK2 0.48 10.0 0.37 5.88e-22 Blood protein levels; BRCA cis rs561341 0.769 rs12941700 chr17:30185022 A/G cg23018236 chr17:30244563 NA 0.61 9.24 0.34 3.49e-19 Hip circumference adjusted for BMI; BRCA cis rs738321 0.725 rs5756926 chr22:38542613 T/C cg20207973 chr22:38506712 BAIAP2L2 0.38 9.22 0.34 4.39e-19 Breast cancer; BRCA cis rs826838 0.804 rs6580755 chr12:39159190 C/T cg26384229 chr12:38710491 ALG10B 0.81 20.78 0.64 1.13e-73 Heart rate; BRCA cis rs703842 1.000 rs8181644 chr12:58173466 A/G cg00677455 chr12:58241039 CTDSP2 0.61 13.77 0.48 5.58e-38 Multiple sclerosis; BRCA cis rs9649213 0.593 rs7796611 chr7:97908223 A/G cg21770322 chr7:97807741 LMTK2 0.41 10.94 0.4 1.14e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.5 0.35 4e-20 Menopause (age at onset); BRCA cis rs9287719 0.649 rs10190774 chr2:10718746 T/A cg00105475 chr2:10696890 NA 0.41 9.18 0.34 5.97e-19 Prostate cancer; BRCA cis rs6714710 0.580 rs11692470 chr2:98520564 T/C cg26665480 chr2:98280029 ACTR1B 0.59 13.64 0.47 2.36e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs6484504 0.576 rs158140 chr11:31212971 T/C cg26647111 chr11:31128758 NA -0.44 -9.67 -0.36 9.59e-21 Red blood cell count; BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg00149659 chr3:10157352 C3orf10 0.8 13.68 0.48 1.56e-37 Alzheimer's disease; BRCA cis rs12762955 0.528 rs10903358 chr10:1102386 G/A cg18964960 chr10:1102726 WDR37 0.66 9.22 0.34 4.41e-19 Response to angiotensin II receptor blocker therapy; BRCA trans rs1973993 0.567 rs2800431 chr1:97000998 C/T cg10631902 chr5:14652156 NA 0.47 14.22 0.49 4.78e-40 Weight; BRCA cis rs13064411 0.627 rs28536176 chr3:113143625 T/C cg18753928 chr3:113234510 CCDC52 -0.52 -9.73 -0.36 5.87e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg18806716 chr10:30721971 MAP3K8 0.43 10.12 0.37 2.04e-22 Inflammatory bowel disease; BRCA cis rs9467711 0.538 rs36012762 chr6:25980523 A/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.24 0.34 3.63e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs6121246 0.609 rs2376998 chr20:30340663 T/C cg13852791 chr20:30311386 BCL2L1 0.84 18.19 0.58 7.19e-60 Mean corpuscular hemoglobin; BRCA cis rs651907 0.557 rs34181125 chr3:101490278 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.47 0.52 4.14e-46 Colorectal cancer; BRCA trans rs6600671 0.934 rs12131379 chr1:121293437 T/C cg00646200 chr1:148855367 NA 0.32 8.21 0.31 1.24e-15 Hip geometry; BRCA cis rs16976116 0.901 rs28589384 chr15:55494366 A/G cg11288833 chr15:55489084 RSL24D1 0.48 10.67 0.39 1.39e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35306767 0.951 rs12777021 chr10:967270 T/C cg20503657 chr10:835505 NA 1.09 18.05 0.58 3.54e-59 Eosinophil percentage of granulocytes; BRCA cis rs1401999 1.000 rs939338 chr3:183704068 A/G cg01324343 chr3:183735012 ABCC5 -0.85 -21.93 -0.66 7.07e-80 Anterior chamber depth; BRCA cis rs7666738 0.830 rs28761309 chr4:98867393 C/T cg05340658 chr4:99064831 C4orf37 0.61 14.56 0.5 1.14e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs16854884 0.558 rs6768153 chr3:143667429 C/A cg06585982 chr3:143692056 C3orf58 0.43 8.71 0.33 2.67e-17 Economic and political preferences (feminism/equality); BRCA cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.58 12.38 0.44 1.07e-31 Lymphocyte percentage of white cells; BRCA cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg07493874 chr5:1342172 CLPTM1L -0.48 -13.91 -0.48 1.24e-38 Lung cancer; BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg08805041 chr16:621841 PIGQ -0.3 -8.05 -0.3 4.03e-15 Height; BRCA cis rs2204008 0.806 rs3922574 chr12:38329069 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.33 0.38 3.05e-23 Bladder cancer; BRCA cis rs67478160 0.643 rs3818085 chr14:104215985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.17 -0.4 1.33e-26 Schizophrenia; BRCA trans rs208520 0.690 rs10455595 chr6:66738034 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.79 0.64 1.05e-73 Exhaled nitric oxide output; BRCA cis rs700651 0.789 rs1813106 chr2:198880589 A/G cg00792783 chr2:198669748 PLCL1 0.38 8.75 0.33 1.91e-17 Intracranial aneurysm; BRCA cis rs12477438 0.798 rs2084987 chr2:99587885 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -17.74 -0.57 1.42e-57 Chronic sinus infection; BRCA cis rs11229555 0.645 rs7117080 chr11:58178677 C/G cg15696309 chr11:58395628 NA -0.4 -8.9 -0.33 5.8e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6545883 0.894 rs2600672 chr2:61536740 A/G cg15711740 chr2:61764176 XPO1 -0.51 -13.15 -0.46 3.79e-35 Tuberculosis; BRCA cis rs769267 0.965 rs735273 chr19:19385411 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.94e-30 Tonsillectomy; BRCA cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg22906224 chr7:99728672 NA 0.46 8.72 0.33 2.31e-17 Coronary artery disease; BRCA cis rs2625529 0.689 rs12161990 chr15:72202440 T/C cg16672083 chr15:72433130 SENP8 0.7 16.17 0.54 1.44e-49 Red blood cell count; BRCA cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg11663144 chr21:46675770 NA -0.57 -13.28 -0.47 1.03e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs56104184 0.775 rs17272707 chr19:49404535 T/G cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.91 -0.36 1.24e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs490234 0.841 rs513568 chr9:128411854 G/A cg14078157 chr9:128172775 NA -0.34 -7.98 -0.3 6.88e-15 Mean arterial pressure; BRCA cis rs61931739 0.500 rs12367292 chr12:33998075 T/C cg06521331 chr12:34319734 NA -0.62 -11.13 -0.4 2.05e-26 Morning vs. evening chronotype; BRCA trans rs2727020 0.513 rs10839307 chr11:49609843 A/C cg15704280 chr7:45808275 SEPT13 -0.92 -24.75 -0.7 2.5e-95 Coronary artery disease; BRCA cis rs2882667 0.690 rs288002 chr5:138232087 T/C cg04439458 chr5:138467593 SIL1 -0.34 -8.4 -0.32 2.97e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6570726 0.791 rs401561 chr6:145835917 G/T cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.74 12.18 0.43 7.65e-31 Mean platelet volume; BRCA cis rs77972916 0.519 rs13411327 chr2:43515483 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -8.64 -0.32 4.57e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs12477438 0.501 rs2516833 chr2:99777405 T/C cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs11690935 0.959 rs1113389 chr2:172635365 C/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.85 -0.77 1.15e-128 Schizophrenia; BRCA cis rs6132905 0.520 rs2422824 chr20:2647370 C/T cg01629329 chr20:2633258 NOP56;MIR1292 -0.4 -7.91 -0.3 1.16e-14 Mumps; BRCA cis rs10129255 0.536 rs3944157 chr14:107138303 C/T cg07958169 chr14:107095056 NA -0.36 -7.84 -0.3 1.83e-14 Kawasaki disease; BRCA cis rs734999 0.967 rs6672381 chr1:2502834 A/G cg20673091 chr1:2541236 MMEL1 0.33 8.51 0.32 1.27e-16 Ulcerative colitis; BRCA cis rs7264396 0.563 rs6060569 chr20:34290731 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.15 -0.43 1.08e-30 Total cholesterol levels; BRCA cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg27478167 chr7:817139 HEATR2 -0.42 -9.08 -0.34 1.33e-18 Cerebrospinal P-tau181p levels; BRCA cis rs7617773 0.832 rs6775114 chr3:48182620 G/C cg11946769 chr3:48343235 NME6 -0.41 -9.07 -0.34 1.49e-18 Coronary artery disease; BRCA cis rs7666738 0.791 rs1426661 chr4:98874303 C/G cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.58 -10.76 -0.39 6.54e-25 Renal function-related traits (BUN); BRCA cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.4 7.99 0.3 6.48e-15 Tonsillectomy; BRCA cis rs3820928 0.874 rs1917122 chr2:227835681 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.43 -0.32 2.26e-16 Pulmonary function; BRCA cis rs7267979 1.000 rs2424704 chr20:25273929 A/G cg08601574 chr20:25228251 PYGB 0.35 8.5 0.32 1.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs965469 0.779 rs6051820 chr20:3365301 A/G cg25506879 chr20:3388711 C20orf194 -0.48 -9.47 -0.35 5.34e-20 IFN-related cytopenia; BRCA cis rs2153535 0.541 rs6908504 chr6:8456778 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA trans rs9467711 0.584 rs34244947 chr6:26761745 T/C cg01620082 chr3:125678407 NA -0.66 -8.19 -0.31 1.43e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs7662987 0.517 rs1377689 chr4:100021787 A/G cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Smoking initiation; BRCA cis rs9487051 0.844 rs9386792 chr6:109609975 G/A cg12927641 chr6:109611667 NA -0.42 -10.89 -0.4 1.94e-25 Reticulocyte fraction of red cells; BRCA cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg06627628 chr2:24431161 ITSN2 -0.5 -8.24 -0.31 9.770000000000001e-16 Lymphocyte counts; BRCA cis rs6952808 0.792 rs2056480 chr7:1954301 A/G cg14004847 chr7:1930337 MAD1L1 0.44 8.52 0.32 1.12e-16 Bipolar disorder and schizophrenia; BRCA cis rs1865760 0.516 rs9393684 chr6:26075531 G/C cg16482183 chr6:26056742 HIST1H1C 0.55 11.71 0.42 7.66e-29 Height; BRCA cis rs1190552 0.846 rs11160683 chr14:102933347 A/G cg18135206 chr14:102964638 TECPR2 0.43 8.4 0.32 2.92e-16 Blood protein levels; BRCA cis rs72781680 1.000 rs72781634 chr2:24199102 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.05 0.34 1.68e-18 Lymphocyte counts; BRCA cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.32 0.49 1.57e-40 Motion sickness; BRCA cis rs9790314 0.502 rs2404342 chr3:161092562 C/T cg04691961 chr3:161091175 C3orf57 -0.4 -9.05 -0.34 1.77e-18 Morning vs. evening chronotype; BRCA cis rs796364 0.950 rs188146 chr2:200750444 C/T cg23649088 chr2:200775458 C2orf69 0.6 8.89 0.33 6.23e-18 Schizophrenia; BRCA trans rs7395662 0.525 rs4882060 chr11:48441874 G/C cg00717180 chr2:96193071 NA -0.37 -10.34 -0.38 2.76e-23 HDL cholesterol; BRCA cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg04013166 chr16:89971882 TCF25 0.52 9.51 0.35 3.7799999999999997e-20 Skin colour saturation; BRCA cis rs4481887 0.927 rs4551626 chr1:248489128 G/T cg00666640 chr1:248458726 OR2T12 0.32 8.94 0.33 4.09e-18 Common traits (Other); BRCA cis rs2282802 0.685 rs2116790 chr5:139654115 G/A cg26211634 chr5:139558579 C5orf32 0.35 8.34 0.31 4.62e-16 Intelligence (multi-trait analysis); BRCA cis rs244731 0.959 rs4976677 chr5:176629546 G/A cg06060754 chr5:176797920 RGS14 -0.66 -10.19 -0.37 1.1e-22 Urate levels in lean individuals; BRCA cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg04450456 chr4:17643702 FAM184B 0.34 9.77 0.36 4.31e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6088580 0.634 rs7271970 chr20:32987666 A/G cg24642439 chr20:33292090 TP53INP2 -0.52 -11.34 -0.41 2.9e-27 Glomerular filtration rate (creatinine); BRCA cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -8.47 -0.32 1.74e-16 Personality dimensions; BRCA cis rs1568889 1.000 rs12803716 chr11:28055111 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.66 0.5 3.63e-42 Bipolar disorder; BRCA cis rs7760949 0.889 rs9396262 chr6:13927418 C/T cg27413430 chr6:13925136 RNF182 0.47 9.37 0.35 1.26e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg06494592 chr3:125709126 NA -0.49 -8.3 -0.31 6.03e-16 Blood pressure (smoking interaction); BRCA cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.84 0.33 9.07e-18 Motion sickness; BRCA cis rs4819052 0.851 rs12626188 chr21:46669258 A/G cg06618935 chr21:46677482 NA -0.36 -7.88 -0.3 1.43e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs9291683 0.509 rs6849717 chr4:9958719 T/C cg26043149 chr18:55253948 FECH -0.41 -9.11 -0.34 1.07e-18 Bone mineral density; BRCA trans rs7829975 0.714 rs4841042 chr8:8664622 A/G cg16141378 chr3:129829833 LOC729375 0.33 8.43 0.32 2.36e-16 Mood instability; BRCA cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg24829409 chr8:58192753 C8orf71 -0.47 -9.04 -0.34 1.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg08280861 chr8:58055591 NA 0.54 8.82 0.33 1.12e-17 Developmental language disorder (linguistic errors); BRCA trans rs637571 0.726 rs689274 chr11:65665988 A/G cg17712092 chr4:129076599 LARP1B -0.67 -17.13 -0.56 2.03e-54 Eosinophil percentage of white cells; BRCA cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs72781680 0.848 rs56218741 chr2:23977377 A/C cg08917208 chr2:24149416 ATAD2B 0.87 12.43 0.44 6.24e-32 Lymphocyte counts; BRCA cis rs16976116 0.806 rs28466870 chr15:55495113 C/T cg11288833 chr15:55489084 RSL24D1 0.48 10.68 0.39 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1784581 0.928 rs1789995 chr6:162396518 C/T cg17173639 chr6:162384350 PARK2 -0.44 -10.6 -0.39 2.69e-24 Itch intensity from mosquito bite; BRCA cis rs2204008 0.529 rs1315350 chr12:38164282 C/A cg26384229 chr12:38710491 ALG10B -0.46 -10.43 -0.38 1.3e-23 Bladder cancer; BRCA cis rs2964802 0.505 rs7717266 chr5:10832134 C/G cg14521931 chr5:10832172 NA -0.58 -12.99 -0.46 2.1e-34 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs12477438 0.520 rs6739579 chr2:99731552 C/T cg08885076 chr2:99613938 TSGA10 0.46 10.71 0.39 1.04e-24 Chronic sinus infection; BRCA cis rs6964587 1.000 rs6944591 chr7:91642714 T/C cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.16e-32 Breast cancer; BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg21782813 chr7:2030301 MAD1L1 -0.38 -10.21 -0.37 9.35e-23 Bipolar disorder and schizophrenia; BRCA cis rs1129187 0.755 rs2274517 chr6:42932715 A/G cg16590910 chr6:42928470 GNMT -0.36 -7.92 -0.3 1.04e-14 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2806561 0.734 rs10799788 chr1:23356864 G/A cg19743168 chr1:23544995 NA 0.35 8.04 0.3 4.5e-15 Height; BRCA cis rs12477438 0.520 rs2516829 chr2:99773201 T/G cg08885076 chr2:99613938 TSGA10 0.46 10.66 0.39 1.52e-24 Chronic sinus infection; BRCA cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16744531 chr19:17905626 B3GNT3 0.54 11.77 0.42 4.59e-29 Tumor biomarkers; BRCA cis rs1215050 0.791 rs1669745 chr4:98842047 G/A cg05340658 chr4:99064831 C4orf37 -0.45 -10.44 -0.38 1.18e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6963495 0.719 rs73190174 chr7:105161216 T/G cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs9300255 0.782 rs12809602 chr12:123768916 T/G cg00376283 chr12:123451042 ABCB9 -0.55 -11.17 -0.4 1.39e-26 Neutrophil percentage of white cells; BRCA cis rs7613875 0.600 rs1061474 chr3:50144951 T/C cg05623727 chr3:50126028 RBM5 -0.52 -12.41 -0.44 7.83e-32 Body mass index; BRCA cis rs425277 0.958 rs262688 chr1:2113565 T/G cg00981070 chr1:2046702 PRKCZ 0.31 8.15 0.31 1.92e-15 Height; BRCA cis rs6952808 0.573 rs12668848 chr7:2020995 G/A cg03354898 chr7:1950403 MAD1L1 -0.43 -9.41 -0.35 8.72e-20 Bipolar disorder and schizophrenia; BRCA cis rs796364 0.806 rs79053279 chr2:201057443 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -9.88 -0.36 1.66e-21 Schizophrenia; BRCA cis rs72627509 0.857 rs56155140 chr4:57824451 G/A cg26694713 chr4:57773883 REST 0.49 9.43 0.35 7.34e-20 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs11674184 0.564 rs746579 chr2:11744694 C/T cg07314298 chr2:11723111 GREB1 -0.66 -12.83 -0.45 1.06e-33 Endometriosis; BRCA cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg02079420 chr8:82753780 SNX16 0.31 8.38 0.31 3.42e-16 Diastolic blood pressure; BRCA cis rs9287719 0.967 rs6432116 chr2:10748615 T/C cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg12641515 chr19:46296257 DMWD 0.68 16.47 0.55 4.45e-51 Coronary artery disease; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs12497850 0.931 rs7647813 chr3:48833348 G/T cg07636037 chr3:49044803 WDR6 0.98 29.26 0.76 4.37e-120 Parkinson's disease; BRCA cis rs2180341 1.000 rs6569486 chr6:127708424 A/C cg27446573 chr6:127587934 RNF146 0.89 20.78 0.64 1.15e-73 Breast cancer; BRCA cis rs10751667 0.643 rs7396623 chr11:934104 G/A cg01483505 chr11:975446 AP2A2 0.33 9.05 0.34 1.71e-18 Alzheimer's disease (late onset); BRCA cis rs782590 0.582 rs2627767 chr2:55926815 A/T cg18811423 chr2:55921094 PNPT1 0.73 24.24 0.69 1.54e-92 Metabolic syndrome; BRCA trans rs8002861 0.641 rs6561148 chr13:44426269 C/T cg17145862 chr1:211918768 LPGAT1 0.46 10.33 0.38 3.21e-23 Leprosy; BRCA cis rs6973256 0.897 rs12530581 chr7:133342955 A/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA trans rs7181230 0.885 rs17723133 chr15:40365418 A/G cg22705835 chr10:65332833 REEP3 0.41 9.37 0.35 1.21e-19 Dehydroepiandrosterone sulphate levels; BRCA cis rs9287719 0.967 rs6721514 chr2:10751062 T/C cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.45e-23 Prostate cancer; BRCA cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg02891314 chr5:179741120 GFPT2 -0.69 -13.97 -0.48 6.98e-39 Height; BRCA cis rs600806 0.888 rs2228604 chr1:109884775 A/C cg20591472 chr1:110008990 SYPL2 0.32 8.16 0.31 1.83e-15 Intelligence (multi-trait analysis); BRCA trans rs7618501 0.633 rs6772095 chr3:49978069 C/T cg21659725 chr3:3221576 CRBN 0.5 12.9 0.45 5.2e-34 Intelligence (multi-trait analysis); BRCA cis rs6745190 0.575 rs6711938 chr2:181977028 C/T cg00481216 chr2:181971175 NA 0.4 9.45 0.35 6.15e-20 White blood cell count; BRCA cis rs10927875 0.691 rs1048302 chr1:16340879 T/G cg21385522 chr1:16154831 NA 0.44 8.16 0.31 1.73e-15 Dilated cardiomyopathy; BRCA cis rs1008375 1.000 rs13119927 chr4:17691640 G/A cg04450456 chr4:17643702 FAM184B -0.32 -9.29 -0.34 2.43e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6570726 0.875 rs416243 chr6:145868081 A/T cg23711669 chr6:146136114 FBXO30 0.63 14.68 0.5 2.85e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs6912958 0.935 rs2179844 chr6:88165773 C/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -9.13 -0.34 8.78e-19 Monocyte percentage of white cells; BRCA cis rs1712517 0.771 rs61869827 chr10:105079439 T/C cg05636881 chr10:105038444 INA 0.35 7.99 0.3 6.39e-15 Migraine; BRCA cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg12219531 chr12:120966889 COQ5 0.52 10.98 0.4 7.98e-26 High light scatter reticulocyte count; BRCA cis rs875971 0.545 rs7783889 chr7:65748353 T/A cg11764359 chr7:65958608 NA 0.65 11.58 0.42 2.9e-28 Aortic root size; BRCA cis rs7246657 0.722 rs3101746 chr19:38146400 T/A cg18154014 chr19:37997991 ZNF793 -0.49 -9.18 -0.34 6.1e-19 Coronary artery calcification; BRCA trans rs911555 0.755 rs8016676 chr14:103904842 C/A cg17675199 chr6:35436792 RPL10A -0.3 -8.11 -0.31 2.52e-15 Intelligence (multi-trait analysis); BRCA cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg02187348 chr16:89574699 SPG7 -0.39 -8.75 -0.33 1.84e-17 Multiple myeloma (IgH translocation); BRCA cis rs72781680 1.000 rs6710426 chr2:24159288 A/G cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg12292205 chr6:26970375 C6orf41 0.72 16.32 0.54 2.62e-50 Autism spectrum disorder or schizophrenia; BRCA cis rs9807989 0.507 rs10204757 chr2:102998974 A/C cg03938978 chr2:103052716 IL18RAP 0.29 8.41 0.32 2.59e-16 Asthma; BRCA cis rs2624839 0.679 rs2624835 chr3:50209049 G/A cg05623727 chr3:50126028 RBM5 0.4 8.57 0.32 7.93e-17 Intelligence (multi-trait analysis); BRCA cis rs897984 0.553 rs2125293 chr16:30863875 T/C cg02466173 chr16:30829666 NA 0.45 8.99 0.33 2.85e-18 Dementia with Lewy bodies; BRCA cis rs2011503 0.941 rs72999068 chr19:19380685 A/G cg15839431 chr19:19639596 YJEFN3 -0.34 -7.81 -0.3 2.28e-14 Bipolar disorder; BRCA cis rs2637266 0.935 rs2579771 chr10:78407544 A/G cg18941641 chr10:78392320 NA 0.36 8.27 0.31 7.75e-16 Pulmonary function; BRCA cis rs12586317 0.620 rs10145433 chr14:35583333 G/A cg16230307 chr14:35515116 FAM177A1 0.69 14.5 0.5 2.22e-41 Psoriasis; BRCA cis rs12618769 0.625 rs2278207 chr2:99163261 T/A cg10123293 chr2:99228465 UNC50 0.44 8.52 0.32 1.11e-16 Bipolar disorder; BRCA cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.18 0.46 2.94e-35 Electroencephalogram traits; BRCA cis rs9653442 0.704 rs10211595 chr2:100726476 G/C cg07810366 chr2:100720526 AFF3 -0.31 -7.92 -0.3 1.05e-14 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs13082711 0.911 rs3755652 chr3:27472936 A/G cg02860705 chr3:27208620 NA -0.59 -10.87 -0.4 2.21e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA trans rs1005277 0.557 rs1854563 chr10:38434961 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -14.01 -0.48 4.47e-39 Extrinsic epigenetic age acceleration; BRCA trans rs1459104 1.000 rs12575696 chr11:55057235 C/T cg03929089 chr4:120376271 NA 0.64 7.84 0.3 1.95e-14 Body mass index; BRCA cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg03433033 chr1:76189801 ACADM -0.76 -17.43 -0.57 5.73e-56 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10046574 0.831 rs10239457 chr7:135116926 A/G cg27474649 chr7:135195673 CNOT4 -0.58 -8.32 -0.31 5.43e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2953145 0.545 rs2975755 chr2:241524919 G/A cg07929629 chr2:241523174 NA 0.55 11.94 0.43 8.39e-30 Bipolar disorder; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs9633740 1.000 rs6586028 chr10:82253984 C/T cg01528321 chr10:82214614 TSPAN14 1.05 20.22 0.62 1.19e-70 Post bronchodilator FEV1; BRCA cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg26752003 chr8:145688521 CYHR1 0.38 8.62 0.32 5.36e-17 Age at first birth; BRCA cis rs1003719 0.654 rs764175 chr21:38517058 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.4 -0.49 6.44e-41 Eye color traits; BRCA cis rs10782582 0.609 rs5745347 chr1:76274520 C/T cg03433033 chr1:76189801 ACADM 0.4 8.21 0.31 1.18e-15 Daytime sleep phenotypes; BRCA cis rs1832871 0.578 rs262820 chr6:158663101 G/T cg07215822 chr6:158701037 NA -0.49 -10.32 -0.38 3.33e-23 Height; BRCA cis rs2880765 0.835 rs2170735 chr15:86043485 G/A cg10818794 chr15:86012489 AKAP13 -0.31 -8.68 -0.32 3.25e-17 Coronary artery disease; BRCA cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg23711669 chr6:146136114 FBXO30 0.73 16.96 0.56 1.59e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.45 8.02 0.3 5e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7312933 0.670 rs2406568 chr12:42552297 G/C cg01256987 chr12:42539512 GXYLT1 -0.46 -9.09 -0.34 1.26e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7772486 0.654 rs702321 chr6:146006695 A/G cg23711669 chr6:146136114 FBXO30 -0.69 -16.31 -0.54 2.95e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg00106254 chr7:1943704 MAD1L1 -0.38 -9.31 -0.35 2.08e-19 Bipolar disorder and schizophrenia; BRCA cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg22467129 chr15:76604101 ETFA -0.47 -10.31 -0.38 3.66e-23 Blood metabolite levels; BRCA cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg13319975 chr6:146136371 FBXO30 0.42 9.76 0.36 4.71e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg01802117 chr1:53393560 SCP2 -0.36 -8.39 -0.31 3.16e-16 Monocyte count; BRCA trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 9.35e-15 Corneal astigmatism; BRCA cis rs2404618 0.624 rs7012381 chr8:1475357 C/T cg13402656 chr8:1511478 DLGAP2 -0.48 -11.14 -0.4 1.83e-26 Lung cancer; BRCA cis rs933688 1.000 rs332529 chr5:90789470 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.89 17.71 0.57 2.18e-57 Smoking behavior; BRCA cis rs9790314 1.000 rs4597724 chr3:160963110 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.1 -0.49 1.64e-39 Morning vs. evening chronotype; BRCA cis rs7586879 0.575 rs6744205 chr2:25133148 T/C cg01884057 chr2:25150051 NA 0.34 9.0 0.34 2.62e-18 Body mass index; BRCA cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg14983838 chr19:29218262 NA 0.56 10.85 0.39 2.64e-25 Methadone dose in opioid dependence; BRCA cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.48 -9.91 -0.37 1.23e-21 Monocyte percentage of white cells; BRCA cis rs10504229 0.683 rs10504223 chr8:58140944 G/A cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs2882667 0.690 rs13177415 chr5:138249940 G/T cg04439458 chr5:138467593 SIL1 -0.31 -7.85 -0.3 1.77e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg00149659 chr3:10157352 C3orf10 0.81 14.21 0.49 5.29e-40 Alzheimer's disease; BRCA cis rs2243480 1.000 rs316329 chr7:65608416 A/C cg18252515 chr7:66147081 NA -1.05 -15.87 -0.53 4.76e-48 Diabetic kidney disease; BRCA trans rs35110281 0.774 rs9978811 chr21:44998683 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.28 0.31 7.06e-16 Mean corpuscular volume; BRCA cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg16325326 chr1:53192061 ZYG11B 0.91 24.68 0.7 5.47e-95 Monocyte count; BRCA cis rs1451375 0.550 rs10239830 chr7:50603829 A/G cg18232548 chr7:50535776 DDC 0.44 9.24 0.34 3.68e-19 Malaria; BRCA cis rs4713118 0.527 rs4713151 chr6:28136356 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Parkinson's disease; BRCA cis rs2839627 0.638 rs9974287 chr21:44317003 T/G cg03543861 chr21:44258195 NA 0.43 8.05 0.3 3.95e-15 Information processing speed; BRCA cis rs34779708 0.966 rs35146199 chr10:35460939 T/C cg03585969 chr10:35415529 CREM 0.56 11.58 0.42 2.9e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7520050 0.966 rs7540325 chr1:46338217 A/T cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2549003 1.000 rs2549005 chr5:131827191 C/T cg21138405 chr5:131827807 IRF1 0.36 10.75 0.39 7.05e-25 Asthma (sex interaction); BRCA cis rs858239 0.601 rs10255228 chr7:23158863 G/T cg23682824 chr7:23144976 KLHL7 0.45 12.06 0.43 2.53e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg00106254 chr7:1943704 MAD1L1 -0.32 -7.89 -0.3 1.34e-14 Bipolar disorder and schizophrenia; BRCA cis rs6430585 0.528 rs115469964 chr2:136696608 A/C cg07169764 chr2:136633963 MCM6 1.27 26.67 0.73 6.92e-106 Corneal structure; BRCA cis rs2304069 0.913 rs7734382 chr5:149383241 A/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.75 16.11 0.54 2.92e-49 HIV-1 control; BRCA cis rs3784262 0.528 rs11071364 chr15:58334113 C/G cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.4 -0.35 9.93e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs13046373 0.534 rs9305426 chr21:31964916 A/C cg06468780 chr21:31798236 KRTAP13-3 0.38 9.2 0.34 5e-19 HDL cholesterol; BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg06468780 chr21:31798236 KRTAP13-3 0.36 8.97 0.33 3.29e-18 HDL cholesterol; BRCA cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs796364 0.806 rs76568708 chr2:200929531 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.76 -11.6 -0.42 2.39e-28 Schizophrenia; BRCA cis rs13082711 0.516 rs13084067 chr3:27358935 A/T cg02860705 chr3:27208620 NA 0.61 11.73 0.42 6.55e-29 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs17401966 0.964 rs34215045 chr1:10361679 G/A cg03954927 chr1:10346856 KIF1B 0.46 13.08 0.46 8.41e-35 Hepatocellular carcinoma; BRCA cis rs6942756 1.000 rs7780886 chr7:128879347 G/A cg02491457 chr7:128862824 NA -0.73 -14.91 -0.51 2.25e-43 White matter hyperintensity burden; BRCA trans rs6952808 0.501 rs3778999 chr7:2180885 G/A cg04565464 chr8:145669602 NFKBIL2 0.4 8.65 0.32 4.09e-17 Bipolar disorder and schizophrenia; BRCA cis rs11098499 0.821 rs3775852 chr4:120454556 A/G cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs4803468 1.000 rs284652 chr19:41928652 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -23.23 -0.68 5.32e-87 Height; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs66782572 1 rs66782572 chr3:52567617 A/G cg07507251 chr3:52567010 NT5DC2 0.39 9.31 0.35 1.97e-19 Hemoglobin concentration; BRCA trans rs2204008 0.658 rs11495742 chr12:38395688 C/A cg06521331 chr12:34319734 NA -0.51 -9.16 -0.34 7.24e-19 Bladder cancer; BRCA cis rs6540559 0.611 rs926347 chr1:209965193 T/C cg21951975 chr1:209979733 IRF6 0.39 8.18 0.31 1.5e-15 Cleft lip with or without cleft palate; BRCA cis rs17092148 0.887 rs4911431 chr20:33158318 G/A cg16810054 chr20:33298113 TP53INP2 -0.48 -10.39 -0.38 1.83e-23 Neuroticism; BRCA cis rs12200782 0.530 rs9379892 chr6:26582414 G/A cg09904177 chr6:26538194 HMGN4 0.36 7.82 0.3 2.16e-14 Small cell lung carcinoma; BRCA cis rs1865760 0.623 rs12216125 chr6:25997458 C/T cg16482183 chr6:26056742 HIST1H1C 0.61 12.35 0.44 1.47e-31 Height; BRCA cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.51 0.52 2.68e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs11696845 0.604 rs1980577 chr20:43382112 A/G cg25301532 chr20:43378953 KCNK15 0.46 10.84 0.39 3.13e-25 Obesity-related traits; BRCA cis rs6028335 0.577 rs16987738 chr20:37625015 G/T cg16355469 chr20:37678765 NA -0.47 -8.56 -0.32 8.4e-17 Alcohol and nicotine co-dependence; BRCA cis rs1997103 1.000 rs4947499 chr7:55407196 T/C cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg11833968 chr6:79620685 NA -0.46 -10.52 -0.38 5.42e-24 Intelligence (multi-trait analysis); BRCA cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.47 -11.21 -0.41 9.83e-27 IgG glycosylation; BRCA trans rs629535 0.814 rs571682 chr8:70062793 A/G cg21567404 chr3:27674614 NA 0.89 18.27 0.59 2.64e-60 Dupuytren's disease; BRCA cis rs10504229 1.000 rs61998258 chr8:58192284 T/C cg14926445 chr8:58193284 C8orf71 -0.47 -8.92 -0.33 4.83e-18 Developmental language disorder (linguistic errors); BRCA cis rs11229555 0.645 rs4367960 chr11:58194961 C/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg25482853 chr8:67687455 SGK3 1.06 17.17 0.56 1.31e-54 Lung disease severity in cystic fibrosis; BRCA cis rs7512552 0.839 rs3896342 chr1:150411312 T/C cg15654264 chr1:150340011 RPRD2 0.43 9.25 0.34 3.25e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs59698941 0.550 rs12652469 chr5:132182765 A/G cg14825688 chr5:132208181 LEAP2 -0.37 -8.65 -0.32 4.12e-17 Apolipoprotein A-IV levels; BRCA cis rs12586317 0.547 rs74243586 chr14:35477325 C/T cg16230307 chr14:35515116 FAM177A1 0.73 15.28 0.52 3.85e-45 Psoriasis; BRCA cis rs3849570 1.000 rs4411908 chr3:81802418 A/C cg07356753 chr3:81810745 GBE1 -0.44 -10.67 -0.39 1.42e-24 Waist circumference;Body mass index; BRCA cis rs1059312 0.808 rs900982 chr12:129304369 G/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.33 10.99 0.4 7.42e-26 Systemic lupus erythematosus; BRCA cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg05707623 chr12:122985044 ZCCHC8 -0.46 -9.49 -0.35 4.6e-20 Body mass index; BRCA cis rs17376456 1.000 rs10514382 chr5:93566534 G/A cg21475434 chr5:93447410 FAM172A 0.74 9.2 0.34 4.89e-19 Diabetic retinopathy; BRCA cis rs875971 0.862 rs778705 chr7:65861115 G/A cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs769267 0.930 rs7254748 chr19:19397479 A/C cg17414380 chr19:19431394 KIAA0892;SF4 0.48 10.01 0.37 5.18e-22 Tonsillectomy; BRCA cis rs113835537 0.597 rs7939759 chr11:66337964 C/T cg24851651 chr11:66362959 CCS 0.44 8.41 0.32 2.67e-16 Airway imaging phenotypes; BRCA cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs8103278 1.000 rs8102876 chr19:46332842 C/T cg12641515 chr19:46296257 DMWD -0.54 -11.74 -0.42 5.67e-29 Coronary artery disease; BRCA trans rs11098499 0.863 rs7664986 chr4:120429952 A/C cg25214090 chr10:38739885 LOC399744 0.55 12.23 0.44 4.59e-31 Corneal astigmatism; BRCA cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg06552810 chr11:31128660 NA -0.39 -8.65 -0.32 4.1e-17 Red blood cell count; BRCA cis rs17401966 0.522 rs10864450 chr1:10333959 G/T cg03954927 chr1:10346856 KIF1B 0.34 10.29 0.38 4.51e-23 Hepatocellular carcinoma; BRCA cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg12863693 chr15:85201151 NMB -0.37 -8.86 -0.33 8.17e-18 P wave terminal force; BRCA cis rs10479542 0.752 rs12658664 chr5:178986987 C/T cg19723775 chr5:179050963 HNRNPH1 0.37 8.94 0.33 4.15e-18 Lung cancer; BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg22920501 chr2:26401640 FAM59B -0.67 -11.5 -0.41 5.96e-28 Gut microbiome composition (summer); BRCA cis rs13118159 0.778 rs12650998 chr4:1338832 T/C cg02475777 chr4:1388615 CRIPAK 0.37 8.16 0.31 1.84e-15 Longevity; BRCA cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg22974920 chr21:40686053 BRWD1 -0.37 -8.55 -0.32 8.87e-17 Cognitive function; BRCA trans rs7615952 0.599 rs6766327 chr3:125723677 C/G cg07211511 chr3:129823064 LOC729375 -0.62 -10.96 -0.4 9.45e-26 Blood pressure (smoking interaction); BRCA cis rs2404602 0.735 rs2280306 chr15:76652258 C/G cg23625390 chr15:77176239 SCAPER -0.54 -13.18 -0.46 2.81e-35 Blood metabolite levels; BRCA cis rs6964587 1.000 rs35653487 chr7:91745441 C/G cg01689657 chr7:91764605 CYP51A1 0.23 8.31 0.31 5.54e-16 Breast cancer; BRCA cis rs801193 1.000 rs2286684 chr7:66129830 G/T cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.48e-43 Aortic root size; BRCA cis rs6597981 0.604 rs7945912 chr11:750849 A/T cg01741372 chr11:783889 NA 0.44 10.51 0.38 6.3e-24 Breast cancer; BRCA cis rs10782582 0.609 rs78748984 chr1:76340467 G/A cg03433033 chr1:76189801 ACADM -0.42 -8.58 -0.32 7.34e-17 Daytime sleep phenotypes; BRCA cis rs950169 0.580 rs17532346 chr15:85171495 A/C cg12863693 chr15:85201151 NMB 0.57 12.07 0.43 2.33e-30 Schizophrenia; BRCA cis rs1949733 0.656 rs2688243 chr4:8436286 A/G cg11789530 chr4:8429930 ACOX3 0.59 14.86 0.51 4.12e-43 Response to antineoplastic agents; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg10729496 chr3:10149963 C3orf24 -0.47 -8.97 -0.33 3.22e-18 Alzheimer's disease; BRCA cis rs3820928 0.874 rs1054413 chr2:227867719 A/G cg11843606 chr2:227700838 RHBDD1 0.4 8.78 0.33 1.51e-17 Pulmonary function; BRCA cis rs6089829 0.962 rs6062778 chr20:61663959 A/G cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs1005277 0.579 rs176838 chr10:38371899 A/T cg00409905 chr10:38381863 ZNF37A 0.55 11.86 0.42 1.82e-29 Extrinsic epigenetic age acceleration; BRCA cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg12379764 chr21:47803548 PCNT 0.64 15.6 0.53 9.68e-47 Testicular germ cell tumor; BRCA cis rs3739998 0.692 rs11007864 chr10:30313117 T/C cg12786570 chr10:30316432 KIAA1462 0.45 9.45 0.35 6.37e-20 Coronary heart disease; BRCA cis rs76419734 0.510 rs3943980 chr4:106676766 G/A cg24545054 chr4:106630052 GSTCD;INTS12 -0.43 -9.3 -0.35 2.16e-19 Post bronchodilator FEV1; BRCA cis rs7829975 0.606 rs891570 chr8:8794454 G/A cg08975724 chr8:8085496 FLJ10661 -0.41 -8.8 -0.33 1.28e-17 Mood instability; BRCA cis rs6060717 0.536 rs8125966 chr20:34511823 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.12 -0.31 2.41e-15 Hip circumference adjusted for BMI; BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg03709012 chr19:19516395 GATAD2A 0.72 15.68 0.53 4.14e-47 Tonsillectomy; BRCA cis rs10927875 0.830 rs1763610 chr1:16335527 C/G cg21385522 chr1:16154831 NA -0.53 -9.93 -0.37 1.05e-21 Dilated cardiomyopathy; BRCA cis rs9942416 0.517 rs116509898 chr5:74994361 C/T cg19683494 chr5:74908142 NA 0.49 9.17 0.34 6.53e-19 Age-related disease endophenotypes; BRCA cis rs1577917 0.740 rs9344542 chr6:86393905 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 13.22 0.46 1.94e-35 Response to antipsychotic treatment; BRCA cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.546 rs3911415 chr4:98692401 T/A cg05340658 chr4:99064831 C4orf37 0.56 10.89 0.4 1.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7927592 0.913 rs948316 chr11:68309670 G/T cg20283391 chr11:68216788 NA -0.46 -9.07 -0.34 1.41e-18 Total body bone mineral density; BRCA cis rs4671400 0.516 rs2600671 chr2:61394851 A/G cg15711740 chr2:61764176 XPO1 -0.45 -9.23 -0.34 3.88e-19 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs7267979 1.000 rs2259837 chr20:25280205 T/C cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs459571 0.606 rs457420 chr9:136909261 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.47 9.1 0.34 1.17e-18 Platelet distribution width; BRCA trans rs1005277 0.579 rs1780130 chr10:38485378 T/A cg23533926 chr12:111358616 MYL2 -0.44 -9.17 -0.34 6.19e-19 Extrinsic epigenetic age acceleration; BRCA cis rs7772486 0.754 rs697053 chr6:145989807 T/C cg05347473 chr6:146136440 FBXO30 -0.42 -8.25 -0.31 9.23e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089829 1.000 rs6089829 chr20:61669036 C/T cg03213289 chr20:61660250 NA -0.55 -14.5 -0.5 2.06e-41 Prostate cancer (SNP x SNP interaction); BRCA cis rs6005807 0.719 rs60693420 chr22:29045930 T/C cg12565055 chr22:29076175 TTC28 0.5 9.36 0.35 1.32e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs6831352 0.918 rs29001203 chr4:100053091 A/G cg12011299 chr4:100065546 ADH4 -0.5 -11.68 -0.42 1.1e-28 Alcohol dependence; BRCA cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg03161606 chr19:29218774 NA 0.43 8.03 0.3 4.74e-15 Methadone dose in opioid dependence; BRCA cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg04727924 chr7:799746 HEATR2 0.46 7.83 0.3 2.06e-14 Cerebrospinal P-tau181p levels; BRCA cis rs6087990 0.899 rs4911107 chr20:31374991 G/A cg13636640 chr20:31349939 DNMT3B 0.69 22.77 0.67 1.65e-84 Ulcerative colitis; BRCA cis rs4481887 0.927 rs9651176 chr1:248447343 A/G cg00666640 chr1:248458726 OR2T12 0.34 9.07 0.34 1.42e-18 Common traits (Other); BRCA cis rs1372520 0.935 rs1372519 chr4:90757309 A/G cg15133208 chr4:90757351 SNCA -0.44 -9.08 -0.34 1.29e-18 Neuroticism; BRCA cis rs79839061 0.656 rs28662837 chr4:879776 G/A cg07828340 chr4:882639 GAK 1.05 14.37 0.49 8.71e-41 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.837 rs11168504 chr12:37964922 G/T cg06521331 chr12:34319734 NA -0.53 -9.62 -0.36 1.55e-20 Bladder cancer; BRCA cis rs6831352 0.918 rs29001194 chr4:100054844 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg24642439 chr20:33292090 TP53INP2 -0.54 -11.85 -0.42 2.08e-29 Glomerular filtration rate (creatinine); BRCA cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg20503657 chr10:835505 NA 0.95 14.3 0.49 1.8e-40 Eosinophil percentage of granulocytes; BRCA cis rs1707322 1.000 rs1612419 chr1:46546945 T/C cg03146154 chr1:46216737 IPP -0.47 -10.14 -0.37 1.61e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4074536 0.622 rs28563907 chr1:116319365 C/T cg21648376 chr1:116311395 CASQ2 -0.54 -8.91 -0.33 5.14e-18 QRS duration; BRCA cis rs10504229 0.683 rs59528137 chr8:58138565 C/T cg08219700 chr8:58056026 NA 0.61 9.75 0.36 4.97e-21 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs11098499 0.954 rs13107475 chr4:120393011 A/T cg09307838 chr4:120376055 NA 0.76 17.11 0.56 2.47e-54 Corneal astigmatism; BRCA cis rs7809950 0.678 rs62482507 chr7:107024488 T/G cg23024343 chr7:107201750 COG5 -0.49 -9.95 -0.37 8.9e-22 Coronary artery disease; BRCA cis rs921968 0.643 rs532475 chr2:219434208 C/T cg02176678 chr2:219576539 TTLL4 0.4 10.84 0.39 3.1e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs4234798 0.500 rs10937793 chr4:7219614 C/T cg18431297 chr4:7219810 SORCS2 0.38 10.67 0.39 1.43e-24 Insulin-like growth factors; BRCA cis rs6964587 0.869 rs2013334 chr7:91549657 G/A cg17063962 chr7:91808500 NA -0.51 -11.83 -0.42 2.54e-29 Breast cancer; BRCA cis rs6815814 0.861 rs28393318 chr4:38784267 A/G cg06935464 chr4:38784597 TLR10 0.46 9.03 0.34 2.03e-18 Breast cancer; BRCA cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.65 0.39 1.73e-24 Motion sickness; BRCA cis rs17376456 1.000 rs66978370 chr5:93553633 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.55 0.32 9.24e-17 Diabetic retinopathy; BRCA cis rs12618769 0.597 rs17031905 chr2:99070902 A/G cg10123293 chr2:99228465 UNC50 0.4 8.13 0.31 2.32e-15 Bipolar disorder; BRCA cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg04455712 chr21:45112962 RRP1B 0.4 10.47 0.38 8.8e-24 Mean corpuscular volume; BRCA cis rs9942416 0.660 rs67054144 chr5:74991443 G/A cg19683494 chr5:74908142 NA 0.48 9.01 0.34 2.33e-18 Age-related disease endophenotypes; BRCA cis rs4363385 0.818 rs2339492 chr1:152985552 G/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.04 -0.34 1.83e-18 Inflammatory skin disease; BRCA cis rs965469 0.779 rs6037581 chr20:3351595 C/T cg25506879 chr20:3388711 C20orf194 -0.44 -8.86 -0.33 7.9e-18 IFN-related cytopenia; BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg24829409 chr8:58192753 C8orf71 0.5 8.53 0.32 1.06e-16 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs880470 chr4:98922522 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.37 0.38 2.18e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs8005677 1.000 rs2295685 chr14:23398153 A/G cg01529538 chr14:23388837 RBM23 0.41 11.11 0.4 2.43e-26 Cognitive ability (multi-trait analysis); BRCA cis rs17270561 0.609 rs4464787 chr6:25733558 G/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.77 0.33 1.65e-17 Iron status biomarkers; BRCA cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg15212455 chr7:39170539 POU6F2 0.39 8.54 0.32 9.93e-17 IgG glycosylation; BRCA cis rs10193935 0.901 rs92303 chr2:42656337 A/G cg27598129 chr2:42591480 NA 0.79 13.27 0.46 1.19e-35 Colonoscopy-negative controls vs population controls; BRCA cis rs10791323 0.627 rs2723614 chr11:133705871 T/G cg15485101 chr11:133734466 NA 0.39 9.37 0.35 1.18e-19 Childhood ear infection; BRCA cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 14.94 0.51 1.71e-43 Colorectal cancer; BRCA cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 15.06 0.51 4.2e-44 Colorectal cancer; BRCA cis rs13046373 0.535 rs7276743 chr21:31984545 C/T cg24082983 chr21:31802169 KRTAP13-4 0.33 8.05 0.3 4.19e-15 HDL cholesterol; BRCA cis rs6912958 0.712 rs6454638 chr6:88329427 C/T cg12350822 chr6:88032061 C6orf162;GJB7 0.3 8.59 0.32 6.75e-17 Monocyte percentage of white cells; BRCA cis rs4689592 0.503 rs10516184 chr4:7060959 C/T cg06697600 chr4:7070879 GRPEL1 -0.57 -10.08 -0.37 2.82e-22 Monocyte percentage of white cells; BRCA cis rs9790314 0.696 rs9290069 chr3:160890946 A/G cg04691961 chr3:161091175 C3orf57 -0.35 -7.96 -0.3 7.85e-15 Morning vs. evening chronotype; BRCA cis rs1355223 0.506 rs11032894 chr11:34865544 T/C cg11058730 chr11:34937778 PDHX;APIP -0.49 -9.5 -0.35 4.21e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs6582630 0.519 rs7305545 chr12:38349223 G/A cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 9.43e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs4363385 0.747 rs2075739 chr1:152975495 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.63e-21 Inflammatory skin disease; BRCA cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.88 -0.3 1.46e-14 Electroencephalogram traits; BRCA cis rs708547 0.836 rs1713997 chr4:57843863 G/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.56 -11.18 -0.4 1.27e-26 Response to bleomycin (chromatid breaks); BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg01262667 chr19:19385393 TM6SF2 0.39 9.73 0.36 5.99e-21 Tonsillectomy; BRCA cis rs60843830 1.000 rs10193373 chr2:281886 T/G cg00108164 chr2:264199 ACP1;SH3YL1 0.72 14.36 0.49 9.93e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10899021 0.920 rs11236181 chr11:74345823 A/C cg25880958 chr11:74394337 NA -0.47 -7.87 -0.3 1.57e-14 Response to metformin (IC50); BRCA cis rs7772486 0.641 rs9390370 chr6:146357569 C/T cg23711669 chr6:146136114 FBXO30 0.67 13.65 0.48 1.97e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 13.0 0.46 1.82e-34 Colorectal cancer; BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.06 -0.4 3.82e-26 Lymphocyte counts; BRCA cis rs4588572 0.644 rs10061149 chr5:77744201 G/A cg11547950 chr5:77652471 NA -0.45 -8.59 -0.32 6.86e-17 Triglycerides; BRCA cis rs7246657 0.943 rs3745765 chr19:37854235 G/T cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA cis rs9287719 0.601 rs9287718 chr2:10701629 A/T cg00105475 chr2:10696890 NA -0.47 -10.36 -0.38 2.46e-23 Prostate cancer; BRCA cis rs243505 0.898 rs243528 chr7:148415740 T/C cg09806900 chr7:148480153 CUL1 -0.38 -7.92 -0.3 1.04e-14 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13161895 1.000 rs4129403 chr5:179476610 A/G cg02702477 chr5:179499311 RNF130 0.49 8.83 0.33 1.02e-17 LDL cholesterol; BRCA cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg04450456 chr4:17643702 FAM184B 0.34 9.74 0.36 5.17e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7493 1.000 rs12026 chr7:95041016 G/C cg01874867 chr7:94954059 PON1 -0.4 -8.21 -0.31 1.19e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs35306767 0.903 rs11253495 chr10:937064 C/T cg25019033 chr10:957182 NA -0.41 -7.87 -0.3 1.57e-14 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.580 rs9406165 chr6:8488837 C/T cg23788917 chr6:8435910 SLC35B3 0.49 10.67 0.39 1.36e-24 Motion sickness; BRCA cis rs7904368 0.754 rs7091240 chr10:16855683 G/A cg23933602 chr10:16859644 RSU1 0.58 9.04 0.34 1.88e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs1348850 0.874 rs6742951 chr2:178340766 G/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.49 9.76 0.36 4.39e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17685 0.712 rs6953342 chr7:75776753 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 5.04e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2282802 0.685 rs6867870 chr5:139641896 C/A cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.12e-15 Intelligence (multi-trait analysis); BRCA cis rs40363 0.645 rs250627 chr16:3527050 G/A cg21433313 chr16:3507492 NAT15 0.44 9.37 0.35 1.26e-19 Tuberculosis; BRCA cis rs10883723 0.668 rs12414407 chr10:104387019 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.56 -16.65 -0.55 5.47e-52 Allergic disease (asthma, hay fever or eczema); BRCA cis rs1003719 0.715 rs9980353 chr21:38558812 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.49 -0.5 2.46e-41 Eye color traits; BRCA trans rs9325144 0.555 rs11183215 chr12:38693127 G/A cg23762105 chr12:34175262 ALG10 0.38 8.84 0.33 9.16e-18 Morning vs. evening chronotype; BRCA trans rs61931739 0.929 rs10844730 chr12:34026721 C/G cg26384229 chr12:38710491 ALG10B -0.44 -10.28 -0.38 5.01e-23 Morning vs. evening chronotype; BRCA cis rs4713118 0.512 rs2622319 chr6:28120401 G/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.17 0.31 1.68e-15 Parkinson's disease; BRCA trans rs8002861 0.781 rs7322781 chr13:44442238 T/C cg17145862 chr1:211918768 LPGAT1 0.64 16.44 0.55 6.25e-51 Leprosy; BRCA cis rs7647973 1.000 rs7648995 chr3:49438803 C/T cg07636037 chr3:49044803 WDR6 -0.73 -15.84 -0.53 6.49e-48 Menarche (age at onset); BRCA cis rs791888 0.858 rs2180968 chr10:89418730 A/C cg13926569 chr10:89418898 PAPSS2 0.35 8.38 0.31 3.27e-16 Magnesium levels; BRCA cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA cis rs4478858 0.735 rs7526095 chr1:31797581 C/T cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs6484504 0.600 rs7122895 chr11:31346620 G/C cg14844989 chr11:31128820 NA 0.45 9.63 0.36 1.33e-20 Red blood cell count; BRCA cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg19318889 chr4:1322082 MAEA 0.58 11.87 0.42 1.71e-29 Longevity; BRCA cis rs7659604 0.689 rs4283687 chr4:122663460 A/G cg19748678 chr4:122722346 EXOSC9 0.42 8.55 0.32 8.87e-17 Type 2 diabetes; BRCA cis rs11792861 0.926 rs11788825 chr9:111829757 T/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.48 9.93 0.37 1.08e-21 Menarche (age at onset); BRCA trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg27147174 chr7:100797783 AP1S1 0.55 11.1 0.4 2.59e-26 Life satisfaction; BRCA cis rs7811142 0.830 rs6979910 chr7:99940630 A/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.03 0.67 6.2e-86 Platelet count; BRCA cis rs27434 0.583 rs34761 chr5:96153624 C/T cg16492584 chr5:96139282 ERAP1 -0.52 -12.78 -0.45 1.77e-33 Ankylosing spondylitis; BRCA cis rs6570726 0.577 rs9497315 chr6:145791967 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -14.7 -0.5 2.33e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs3784262 0.565 rs2899613 chr15:58347260 T/C cg12031962 chr15:58353849 ALDH1A2 -0.35 -9.23 -0.34 3.86e-19 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs3741151 0.773 rs73544716 chr11:73170061 C/T cg17517138 chr11:73019481 ARHGEF17 0.87 12.43 0.44 6.65e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.6e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.875 rs2748501 chr6:146312258 G/A cg23711669 chr6:146136114 FBXO30 0.75 17.47 0.57 3.78e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088813 1.000 rs2248393 chr20:33926103 C/G cg14752227 chr20:34000481 UQCC 0.39 8.21 0.31 1.21e-15 Height; BRCA cis rs10870270 0.957 rs3829156 chr10:133789386 C/G cg17892150 chr10:133769511 PPP2R2D -0.68 -14.25 -0.49 3.21e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs911119 0.913 rs13043610 chr20:23586941 G/A cg16589663 chr20:23618590 CST3 0.43 7.87 0.3 1.5e-14 Chronic kidney disease; BRCA cis rs11711311 1.000 rs9863050 chr3:113508888 C/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.37 9.73 0.36 5.67e-21 IgG glycosylation; BRCA cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.92 -0.3 1.08e-14 Bipolar disorder; BRCA cis rs12477438 0.501 rs12992218 chr2:99753834 G/A cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs2742234 0.955 rs2503865 chr10:43659536 C/T cg02780029 chr10:43622663 RET -0.4 -9.94 -0.37 9.98e-22 Hirschsprung disease; BRCA cis rs9733 0.596 rs6587518 chr1:150661787 T/C cg17724175 chr1:150552817 MCL1 0.25 8.19 0.31 1.47e-15 Tonsillectomy; BRCA cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.48 0.52 3.93e-46 Colorectal cancer; BRCA cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg24060327 chr5:131705240 SLC22A5 0.6 11.13 0.4 2.01e-26 Breast cancer; BRCA cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg02551604 chr5:131831745 NA -0.4 -14.94 -0.51 1.73e-43 Asthma (sex interaction); BRCA cis rs765787 0.530 rs2899379 chr15:45534799 C/T cg25801113 chr15:45476975 SHF -0.33 -7.98 -0.3 6.83e-15 Uric acid levels; BRCA cis rs1801251 0.711 rs778368 chr2:233745333 G/C cg25237894 chr2:233734115 C2orf82 -0.42 -12.76 -0.45 2.13e-33 Coronary artery disease; BRCA cis rs6867032 0.527 rs4975720 chr5:2010455 C/G cg26168224 chr5:2018326 NA 0.44 11.71 0.42 8.05e-29 Gut microbiome composition (winter); BRCA cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg10556349 chr10:835070 NA 0.6 8.38 0.31 3.46e-16 Eosinophil percentage of granulocytes; BRCA cis rs1059312 0.932 rs4760589 chr12:129284382 T/C cg09035930 chr12:129282057 SLC15A4 0.58 17.23 0.56 6.42e-55 Systemic lupus erythematosus; BRCA cis rs3925075 1.000 rs11859274 chr16:31361059 C/T cg02846316 chr16:31340340 ITGAM 0.53 12.98 0.46 2.25e-34 IgA nephropathy; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00166722 chr3:10149974 C3orf24 0.63 12.17 0.43 8.51e-31 Alzheimer's disease; BRCA trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg23505145 chr19:12996616 KLF1 0.54 12.19 0.43 7.29e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24531977 chr5:56204891 C5orf35 -0.87 -18.4 -0.59 5.13e-61 Initial pursuit acceleration; BRCA cis rs6450176 1.000 rs12521454 chr5:53297304 T/C ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.07 -0.51 3.76e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs372883 0.532 rs388707 chr21:30714776 T/C cg08807101 chr21:30365312 RNF160 -0.35 -8.02 -0.3 5.13e-15 Pancreatic cancer; BRCA cis rs798554 0.660 rs2527687 chr7:2838485 G/A cg09658497 chr7:2847517 GNA12 -0.39 -7.99 -0.3 6.54e-15 Height; BRCA cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs17490626 0.533 rs5030925 chr10:71211150 A/C cg12610070 chr10:71211762 TSPAN15 -0.33 -11.67 -0.42 1.11e-28 Thrombosis; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg04944784 chr2:26401820 FAM59B 0.95 16.37 0.54 1.44e-50 Gut microbiome composition (summer); BRCA cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg11822812 chr5:140052017 DND1 0.31 8.42 0.32 2.49e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs16854884 0.657 rs35877644 chr3:143701755 A/G cg06585982 chr3:143692056 C3orf58 0.42 8.81 0.33 1.14e-17 Economic and political preferences (feminism/equality); BRCA cis rs1997103 1.000 rs6958664 chr7:55404958 T/G cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6598955 0.572 rs12089219 chr1:26638751 C/T cg00852783 chr1:26633632 UBXN11 -0.46 -7.98 -0.3 6.7e-15 Obesity-related traits; BRCA cis rs919433 0.929 rs7592511 chr2:198177974 A/G cg03934865 chr2:198174659 NA -0.43 -9.39 -0.35 1.08e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg08888203 chr3:10149979 C3orf24 0.67 14.34 0.49 1.21e-40 Alzheimer's disease; BRCA cis rs1707322 1.000 rs785486 chr1:46575148 G/C cg03146154 chr1:46216737 IPP -0.42 -8.94 -0.33 4.06e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17604090 0.938 rs28664977 chr7:29685369 C/T cg19413766 chr7:29689036 LOC646762 -0.51 -7.99 -0.3 6.22e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg24110177 chr3:50126178 RBM5 0.52 15.68 0.53 4e-47 Body mass index; BRCA cis rs9517320 0.534 rs3825430 chr13:99129653 C/T cg07423050 chr13:99094983 FARP1 -0.43 -9.3 -0.35 2.23e-19 Longevity; BRCA cis rs7760949 0.852 rs9475800 chr6:13932230 A/G cg27413430 chr6:13925136 RNF182 0.46 9.27 0.34 2.74e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs672059 1.000 rs566625 chr1:183161441 A/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.63 0.32 4.72e-17 Hypertriglyceridemia; BRCA cis rs7727544 0.582 rs116749111 chr5:131462918 G/T cg14196790 chr5:131705035 SLC22A5 0.37 9.06 0.34 1.61e-18 Blood metabolite levels; BRCA cis rs1113500 0.933 rs12132785 chr1:108633083 A/T cg06207961 chr1:108661230 NA 0.46 11.23 0.41 7.89e-27 Growth-regulated protein alpha levels; BRCA cis rs6424115 0.793 rs2502998 chr1:24198327 T/A cg10978503 chr1:24200527 CNR2 0.52 13.93 0.48 9.94e-39 Immature fraction of reticulocytes; BRCA cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg20887711 chr4:1340912 KIAA1530 0.6 13.2 0.46 2.43e-35 Longevity; BRCA cis rs7666738 0.830 rs58696666 chr4:99006913 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs61990749 0.597 rs1978416 chr14:78227901 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.57 0.39 3.61e-24 Fibroblast growth factor basic levels; BRCA cis rs1348850 0.634 rs1534304 chr2:178489264 C/T cg27490568 chr2:178487706 NA 0.43 8.13 0.31 2.22e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6570726 0.870 rs370653 chr6:145823642 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -13.37 -0.47 4.1e-36 Bone mineral density; BRCA cis rs6840360 0.615 rs4696268 chr4:152464723 G/A cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA trans rs3812049 0.737 rs790155 chr5:127498380 C/T cg16011800 chr17:1958478 HIC1 -0.52 -8.47 -0.32 1.73e-16 Lymphocyte counts;Red cell distribution width; BRCA cis rs4363385 0.667 rs78426057 chr1:152964528 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.26 -0.34 3.18e-19 Inflammatory skin disease; BRCA cis rs858239 0.862 rs1728292 chr7:23263474 C/G cg23682824 chr7:23144976 KLHL7 0.31 7.92 0.3 1.07e-14 Cerebrospinal fluid biomarker levels; BRCA cis rs4319547 0.656 rs7975747 chr12:122816995 C/T cg23029597 chr12:123009494 RSRC2 -0.59 -11.39 -0.41 1.69e-27 Body mass index; BRCA trans rs7916697 0.520 rs12265247 chr10:70038398 A/G cg04882175 chr6:131122610 NA -0.31 -8.13 -0.31 2.28e-15 Optic disc area; BRCA cis rs4074536 0.622 rs12125807 chr1:116321310 G/C cg21648376 chr1:116311395 CASQ2 -0.55 -9.13 -0.34 9e-19 QRS duration; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.62 12.66 0.45 5.97e-33 Lymphocyte counts; BRCA cis rs2115630 1.000 rs56074163 chr15:85351332 C/T cg11189052 chr15:85197271 WDR73 -0.33 -7.87 -0.3 1.53e-14 P wave terminal force; BRCA cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg24397884 chr7:158709396 WDR60 -0.98 -24.94 -0.7 2.12e-96 Height; BRCA cis rs4689388 0.856 rs1046314 chr4:6303955 A/G cg25554036 chr4:6271136 WFS1 -0.38 -9.36 -0.35 1.38e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg08999081 chr20:33150536 PIGU 0.35 9.0 0.34 2.55e-18 Coronary artery disease; BRCA cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg00409905 chr10:38381863 ZNF37A -0.49 -10.33 -0.38 3.2e-23 Extrinsic epigenetic age acceleration; BRCA cis rs9368481 0.524 rs9393768 chr6:26885619 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.23 7.94 0.3 8.94e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs698813 0.604 rs1596010 chr2:44491804 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.44 7.88 0.3 1.4e-14 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs798554 1.000 rs798548 chr7:2760935 A/G cg04166393 chr7:2884313 GNA12 0.5 9.97 0.37 7.58e-22 Height; BRCA cis rs6942407 0.546 rs10228392 chr7:86799673 A/T cg02420886 chr7:86849541 C7orf23 0.53 7.85 0.3 1.75e-14 Food allergy; BRCA cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg03264133 chr6:25882463 NA -0.53 -11.12 -0.4 2.27e-26 Intelligence (multi-trait analysis); BRCA cis rs10162002 1.000 rs17078796 chr13:24043830 A/G cg00158254 chr13:24040743 NA -0.56 -9.07 -0.34 1.39e-18 Hypothyroidism; BRCA cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.58 -0.32 7.01e-17 Monocyte percentage of white cells; BRCA cis rs8177253 0.896 rs34252038 chr3:133490621 G/T cg08048268 chr3:133502702 NA -0.33 -8.3 -0.31 6.21e-16 Iron status biomarkers; BRCA cis rs10046574 0.561 rs17481974 chr7:135195701 A/G cg27474649 chr7:135195673 CNOT4 0.67 10.95 0.4 1.07e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg08847533 chr14:75593920 NEK9 -0.86 -21.93 -0.66 6.26e-80 Height; BRCA cis rs2836950 0.565 rs2150413 chr21:40614878 C/T cg11890956 chr21:40555474 PSMG1 -0.62 -13.99 -0.48 5.46e-39 Menarche (age at onset); BRCA cis rs4363385 0.747 rs1984198 chr1:152958584 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.29 -0.34 2.45e-19 Inflammatory skin disease; BRCA cis rs9517320 0.534 rs3858778 chr13:99172249 A/C cg07423050 chr13:99094983 FARP1 0.47 10.64 0.39 1.92e-24 Longevity; BRCA cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg02466173 chr16:30829666 NA -0.54 -11.41 -0.41 1.37e-27 Multiple myeloma; BRCA cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg18016565 chr1:150552671 MCL1 -0.42 -9.56 -0.35 2.55e-20 Tonsillectomy; BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg18758796 chr5:131593413 PDLIM4 0.34 8.9 0.33 5.83e-18 Breast cancer; BRCA cis rs10197940 0.624 rs6724796 chr2:152412813 C/T cg06191203 chr2:152266755 RIF1 -0.36 -10.75 -0.39 6.81e-25 Lung cancer; BRCA cis rs17741873 0.836 rs11000797 chr10:75628224 A/G cg07699608 chr10:75541558 CHCHD1 0.55 8.4 0.32 2.78e-16 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs3768617 0.510 rs2027083 chr1:183088330 T/C ch.1.3577855R chr1:183094577 LAMC1 0.67 17.71 0.57 2.03e-57 Fuchs's corneal dystrophy; BRCA cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg06064525 chr11:970664 AP2A2 -0.51 -17.21 -0.56 8.11e-55 Alzheimer's disease (late onset); BRCA cis rs4900538 0.855 rs12590993 chr14:102844064 A/G cg18135206 chr14:102964638 TECPR2 -0.93 -21.69 -0.65 1.42e-78 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs11190604 1.000 rs3750633 chr10:102308214 C/T cg07080220 chr10:102295463 HIF1AN 0.63 13.94 0.48 9.84e-39 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2116941 1.000 rs8104426 chr19:10338676 G/T cg01850179 chr19:10340795 S1PR2 0.63 12.79 0.45 1.57e-33 Pulse pressure; BRCA cis rs17023223 0.537 rs61319010 chr1:119743011 T/A cg05756136 chr1:119680316 WARS2 -0.43 -8.25 -0.31 8.87e-16 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA trans rs6582630 0.519 rs4436613 chr12:38293653 T/C cg06521331 chr12:34319734 NA -0.47 -8.77 -0.33 1.59e-17 Drug-induced liver injury (flucloxacillin); BRCA trans rs61931739 0.534 rs1352206 chr12:34036668 G/A cg13010199 chr12:38710504 ALG10B 0.4 8.09 0.3 3.05e-15 Morning vs. evening chronotype; BRCA cis rs35110281 0.774 rs162404 chr21:44963264 G/A cg01579765 chr21:45077557 HSF2BP -0.39 -10.63 -0.39 2e-24 Mean corpuscular volume; BRCA cis rs2836974 0.897 rs8128102 chr21:40606414 G/A cg11890956 chr21:40555474 PSMG1 1.05 29.89 0.76 1.74e-123 Cognitive function; BRCA cis rs2677744 0.626 rs3743452 chr15:91497515 C/T cg23684204 chr15:91497937 RCCD1 -0.43 -9.27 -0.34 2.71e-19 Attention deficit hyperactivity disorder; BRCA cis rs9311474 0.508 rs11720243 chr3:52618018 T/C cg18404041 chr3:52824283 ITIH1 -0.37 -11.27 -0.41 5.23e-27 Electroencephalogram traits; BRCA cis rs9325144 0.534 rs6582538 chr12:38629997 A/C cg26384229 chr12:38710491 ALG10B -0.53 -13.44 -0.47 1.85e-36 Morning vs. evening chronotype; BRCA cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.87e-15 Developmental language disorder (linguistic errors); BRCA cis rs10046574 0.831 rs28613647 chr7:135129443 G/A cg27474649 chr7:135195673 CNOT4 0.59 8.34 0.31 4.43e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs2421770 0.530 rs4756218 chr11:35370113 G/A cg13971030 chr11:35366721 SLC1A2 -0.44 -10.04 -0.37 3.9e-22 Staphylococcus aureus nasal carriage (persistent); BRCA cis rs514406 0.792 rs481440 chr1:53344976 C/T cg16325326 chr1:53192061 ZYG11B 0.53 11.66 0.42 1.34e-28 Monocyte count; BRCA cis rs8005677 1.000 rs8005677 chr14:23376678 T/C cg01529538 chr14:23388837 RBM23 0.42 11.56 0.42 3.25e-28 Cognitive ability (multi-trait analysis); BRCA cis rs4808199 1.000 rs12977524 chr19:19568244 A/G cg03709012 chr19:19516395 GATAD2A 1.08 20.88 0.64 3.37e-74 Nonalcoholic fatty liver disease; BRCA cis rs1348850 0.914 rs7573763 chr2:178249808 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 9.86 0.36 1.95e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1994135 0.647 rs1351681 chr12:33698724 G/A cg06521331 chr12:34319734 NA -0.53 -9.16 -0.34 6.69e-19 Resting heart rate; BRCA trans rs61931739 0.534 rs1490109 chr12:34064077 T/C cg26384229 chr12:38710491 ALG10B 0.55 11.87 0.43 1.74e-29 Morning vs. evening chronotype; BRCA cis rs600806 0.815 rs10745356 chr1:109960270 C/A cg20591472 chr1:110008990 SYPL2 0.32 7.89 0.3 1.35e-14 Intelligence (multi-trait analysis); BRCA trans rs2832077 0.883 rs11702413 chr21:30188395 A/C cg14791747 chr16:20752902 THUMPD1 0.4 9.35 0.35 1.49e-19 Cognitive test performance; BRCA cis rs6088580 0.634 rs6088478 chr20:32971719 T/C cg06115741 chr20:33292138 TP53INP2 -0.39 -8.71 -0.33 2.54e-17 Glomerular filtration rate (creatinine); BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg21248554 chr2:27665150 KRTCAP3 -0.34 -8.81 -0.33 1.16e-17 Total body bone mineral density; BRCA cis rs6540559 1.000 rs742214 chr1:209960925 T/C cg22029157 chr1:209979665 IRF6 0.56 12.58 0.45 1.39e-32 Cleft lip with or without cleft palate; BRCA cis rs61990749 0.597 rs28534379 chr14:78172140 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.03 -0.37 4.19e-22 Fibroblast growth factor basic levels; BRCA cis rs5758659 0.652 rs6519301 chr22:42385967 A/G cg15557168 chr22:42548783 NA -0.31 -8.5 -0.32 1.29e-16 Cognitive function; BRCA cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9831754 1.000 rs9822043 chr3:78352113 T/C cg06138941 chr3:78371609 NA -0.81 -17.5 -0.57 2.48e-56 Calcium levels; BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg25036284 chr2:26402008 FAM59B 0.96 15.95 0.53 1.78e-48 Gut microbiome composition (summer); BRCA cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.5e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg16145915 chr7:1198662 ZFAND2A -0.46 -11.62 -0.42 1.82e-28 Longevity;Endometriosis; BRCA cis rs9381107 0.932 rs11756620 chr6:9423799 T/C cg14735645 chr6:9486422 NA -0.47 -8.18 -0.31 1.59e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs10883723 0.810 rs2296581 chr10:104242886 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.62 0.57 6.44e-57 Allergic disease (asthma, hay fever or eczema); BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg21747090 chr2:27597821 SNX17 -0.41 -8.98 -0.33 2.91e-18 Total body bone mineral density; BRCA cis rs992157 0.798 rs7587220 chr2:219160864 C/A cg00012203 chr2:219082015 ARPC2 -0.47 -8.98 -0.33 2.9e-18 Colorectal cancer; BRCA cis rs6545883 0.525 rs1729658 chr2:61373520 C/T cg15711740 chr2:61764176 XPO1 -0.46 -11.32 -0.41 3.35e-27 Tuberculosis; BRCA cis rs3096299 0.967 rs2911255 chr16:89487137 C/T cg08822215 chr16:89438651 ANKRD11 -0.4 -8.47 -0.32 1.68e-16 Multiple myeloma (IgH translocation); BRCA cis rs10496034 1.000 rs80194342 chr2:55223107 T/A cg16098955 chr2:55172992 EML6 0.52 8.61 0.32 5.61e-17 Refractive astigmatism; BRCA cis rs4819052 1.000 rs2297285 chr21:46705621 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 -0.68 -11.18 -0.4 1.25e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9815354 0.680 rs73073262 chr3:42018443 G/T cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.2e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs57221529 0.766 rs4081846 chr5:574019 G/A cg09021430 chr5:549028 NA -0.7 -15.45 -0.52 5.35e-46 Lung disease severity in cystic fibrosis; BRCA cis rs9324022 0.860 rs72698720 chr14:101178715 C/G cg18089426 chr14:101175970 NA 0.64 12.15 0.43 1.03e-30 Plateletcrit; BRCA cis rs897984 0.806 rs12924903 chr16:30928970 C/T cg00531865 chr16:30841666 NA -0.35 -8.19 -0.31 1.45e-15 Dementia with Lewy bodies; BRCA cis rs2204008 0.744 rs11181635 chr12:38378420 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs270601 0.739 rs3900945 chr5:131592870 T/C cg07262247 chr5:131593730 PDLIM4 0.39 9.41 0.35 9.08e-20 Acylcarnitine levels; BRCA cis rs4819052 0.851 rs875621 chr21:46682295 A/G cg11663144 chr21:46675770 NA -0.62 -14.71 -0.5 2.18e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs73242632 1.000 rs73242625 chr4:57856339 A/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.7 8.49 0.32 1.49e-16 Congenital heart disease (maternal effect); BRCA cis rs1949733 1.000 rs2688223 chr4:8471398 T/C cg11789530 chr4:8429930 ACOX3 0.67 17.36 0.57 1.34e-55 Response to antineoplastic agents; BRCA cis rs2904967 0.929 rs554122 chr11:65033874 T/C cg09225861 chr11:65069680 NA 0.39 8.07 0.3 3.62e-15 Mean corpuscular volume; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg09877947 chr5:131593287 PDLIM4 0.42 9.77 0.36 4.16e-21 Acylcarnitine levels; BRCA trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg25517755 chr10:38738941 LOC399744 -0.38 -8.04 -0.3 4.28e-15 Corneal astigmatism; BRCA cis rs9368481 0.678 rs62402024 chr6:26923976 T/C cg12292205 chr6:26970375 C6orf41 0.72 16.24 0.54 6.81e-50 Autism spectrum disorder or schizophrenia; BRCA cis rs11718455 0.960 rs13065591 chr3:43996585 T/C cg08738300 chr3:44038990 NA 0.47 8.79 0.33 1.34e-17 Coronary artery disease; BRCA cis rs1975991 0.765 rs6764972 chr3:187960329 C/T cg15417654 chr3:187959138 LPP -0.34 -8.85 -0.33 8.75e-18 White matter integrity (bipolar disorder risk interaction); BRCA cis rs7103648 0.897 rs2278890 chr11:47399602 G/A cg03711944 chr11:47377212 SPI1 -0.49 -12.48 -0.44 3.65e-32 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg16405210 chr4:1374714 KIAA1530 -0.91 -20.66 -0.63 5.26e-73 Longevity; BRCA cis rs2235642 0.821 rs8051895 chr16:1602811 A/G cg26528668 chr16:1614120 IFT140 0.39 9.0 0.34 2.6e-18 Coronary artery disease; BRCA cis rs637571 0.528 rs11602769 chr11:65594139 T/C cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -8.92 -0.33 5.03e-18 Eosinophil percentage of white cells; BRCA cis rs1348850 0.526 rs4243389 chr2:178379783 G/C cg27490568 chr2:178487706 NA 0.5 8.39 0.32 3.01e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17685 0.753 rs1104879 chr7:75685568 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.43 -9.77 -0.36 4.24e-21 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2762353 0.935 rs2817188 chr6:25807603 A/G cg12310025 chr6:25882481 NA -0.5 -11.89 -0.43 1.37e-29 Blood metabolite levels; BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26314531 chr2:26401878 FAM59B -0.7 -11.53 -0.41 4.6e-28 Gut microbiome composition (summer); BRCA cis rs473651 0.935 rs1103770 chr2:239339281 G/C cg18131467 chr2:239335373 ASB1 0.86 21.85 0.65 1.88e-79 Multiple system atrophy; BRCA trans rs9329221 0.736 rs11250002 chr8:10257041 T/G cg06636001 chr8:8085503 FLJ10661 0.53 10.27 0.38 5.15e-23 Neuroticism; BRCA cis rs6570726 0.846 rs9399559 chr6:145945778 C/T cg23711669 chr6:146136114 FBXO30 0.71 16.97 0.56 1.28e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs1113500 0.933 rs11185259 chr1:108635062 A/G cg06207961 chr1:108661230 NA -0.44 -10.57 -0.39 3.58e-24 Growth-regulated protein alpha levels; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26314531 chr2:26401878 FAM59B -0.9 -16.15 -0.54 1.92e-49 Gut microbiome composition (summer); BRCA cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.54 -14.06 -0.49 2.58e-39 Electrocardiographic conduction measures; BRCA cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg16423285 chr20:60520624 NA 0.43 8.15 0.31 1.95e-15 Body mass index; BRCA cis rs7772486 0.654 rs1011597 chr6:146075672 A/C cg23711669 chr6:146136114 FBXO30 -0.73 -17.29 -0.56 3.15e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg05283184 chr6:79620031 NA -0.43 -10.82 -0.39 3.77e-25 Intelligence (multi-trait analysis); BRCA cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg08355456 chr11:67383691 NA -0.42 -8.61 -0.32 5.75e-17 Mean corpuscular volume; BRCA cis rs701145 0.585 rs1727887 chr3:153839465 G/T cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs4906332 1.000 rs8012127 chr14:103942762 G/A cg26031613 chr14:104095156 KLC1 -0.44 -8.0 -0.3 6.01e-15 Coronary artery disease; BRCA cis rs2180341 0.920 rs9398836 chr6:127576497 T/G cg24812749 chr6:127587940 RNF146 0.87 19.75 0.62 4.07e-68 Breast cancer; BRCA cis rs10883723 0.810 rs10748824 chr10:104274466 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.13 0.62 3.46e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg00701064 chr4:6280414 WFS1 0.64 16.01 0.54 9.19e-49 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs11676348 0.783 rs13035513 chr2:218960680 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.41 -8.53 -0.32 1.09e-16 Ulcerative colitis; BRCA trans rs208520 1.000 rs28773210 chr6:66993566 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.87 14.39 0.49 7.25e-41 Exhaled nitric oxide output; BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.68 11.62 0.42 1.94e-28 Renal function-related traits (BUN); BRCA cis rs6547741 0.816 rs10201652 chr2:27874332 A/C cg27432699 chr2:27873401 GPN1 -0.5 -10.51 -0.38 6.02e-24 Oral cavity cancer; BRCA cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.05 0.37 3.54e-22 Electroencephalogram traits; BRCA cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg03213289 chr20:61660250 NA 0.62 15.95 0.53 1.88e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs9487051 0.872 rs1111864 chr6:109611138 A/G cg21918786 chr6:109611834 NA -0.48 -13.92 -0.48 1.16e-38 Reticulocyte fraction of red cells; BRCA cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg18876405 chr7:65276391 NA -0.57 -13.62 -0.47 3e-37 Aortic root size; BRCA cis rs7312933 0.533 rs11181499 chr12:42818761 A/G cg01256987 chr12:42539512 GXYLT1 -0.42 -8.12 -0.31 2.48e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs75804782 0.521 rs56176151 chr2:239440220 T/C cg01134436 chr17:81009848 B3GNTL1 0.68 8.66 0.32 3.96e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs4664304 0.772 rs12692572 chr2:160743793 G/A cg14819504 chr2:160761413 LY75 0.35 8.42 0.32 2.45e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1865760 0.865 rs9393678 chr6:25945819 C/T cg16482183 chr6:26056742 HIST1H1C 0.5 10.23 0.38 7.56e-23 Height; BRCA cis rs1865721 1.000 rs62089503 chr18:73177766 C/T cg26385618 chr18:73139727 C18orf62 -0.41 -9.2 -0.34 5.01e-19 Intelligence; BRCA cis rs9287719 0.967 rs4669596 chr2:10720572 C/T cg00105475 chr2:10696890 NA 0.44 10.21 0.37 8.73e-23 Prostate cancer; BRCA cis rs7959452 0.558 rs1478464 chr12:69779789 G/C cg14784868 chr12:69753453 YEATS4 0.66 17.8 0.58 6.95e-58 Blood protein levels; BRCA cis rs2425143 1.000 rs56904633 chr20:34400757 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.92 -0.33 4.83e-18 Blood protein levels; BRCA cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg24558204 chr6:135376177 HBS1L 0.49 13.31 0.47 7.44e-36 Red blood cell count; BRCA cis rs4689388 0.926 rs10937717 chr4:6295087 T/A cg25554036 chr4:6271136 WFS1 0.39 9.25 0.34 3.35e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.55 10.5 0.38 6.45e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.867 rs1002053 chr7:65798545 G/A cg18876405 chr7:65276391 NA -0.54 -12.75 -0.45 2.54e-33 Aortic root size; BRCA cis rs7617773 0.817 rs936427 chr3:48301074 A/G cg11946769 chr3:48343235 NME6 -0.68 -13.97 -0.48 6.45e-39 Coronary artery disease; BRCA cis rs9393777 0.557 rs36034627 chr6:27237363 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -7.95 -0.3 8.35e-15 Intelligence (multi-trait analysis); BRCA trans rs7618501 0.633 rs2526751 chr3:50064867 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.08 -0.34 1.31e-18 Intelligence (multi-trait analysis); BRCA cis rs6500602 0.647 rs4786514 chr16:4576798 A/C cg08645402 chr16:4508243 NA 0.4 9.49 0.35 4.63e-20 Schizophrenia; BRCA cis rs1372520 0.684 rs184810 chr4:90697979 T/C cg15133208 chr4:90757351 SNCA 0.4 7.9 0.3 1.2e-14 Neuroticism; BRCA cis rs17095355 0.901 rs12569425 chr10:111758177 G/A cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.77 -0.36 4.23e-21 Biliary atresia; BRCA cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg00745463 chr17:30367425 LRRC37B -0.62 -9.93 -0.37 1.06e-21 Hip circumference adjusted for BMI; BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg23285459 chr7:2802560 GNA12 -0.39 -9.51 -0.35 3.94e-20 Height; BRCA cis rs7772486 0.720 rs6570713 chr6:146075085 G/A cg13319975 chr6:146136371 FBXO30 0.43 10.04 0.37 4.06e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg11764359 chr7:65958608 NA 0.67 14.94 0.51 1.71e-43 Aortic root size; BRCA cis rs2559856 0.935 rs7957666 chr12:102081551 T/C cg12213457 chr12:102090980 CHPT1 -0.37 -8.09 -0.3 3.12e-15 Blood protein levels; BRCA cis rs7267979 1.000 rs2500418 chr20:25382268 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.38 -0.31 3.26e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11969893 0.850 rs3734351 chr6:101307131 C/T cg12253828 chr6:101329408 ASCC3 1.18 17.53 0.57 1.86e-56 Economic and political preferences (immigration/crime); BRCA cis rs7131987 0.903 rs7302129 chr12:29415280 A/T cg09582351 chr12:29534625 ERGIC2 -0.49 -11.77 -0.42 4.32e-29 QT interval; BRCA cis rs9470366 0.816 rs1321310 chr6:36623124 C/T cg08179530 chr6:36648295 CDKN1A -0.5 -10.21 -0.37 8.87e-23 QRS duration; BRCA cis rs2979489 0.891 rs3824107 chr8:30353412 A/G cg26383811 chr8:30366931 RBPMS 0.45 10.71 0.39 1.02e-24 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs9486719 0.948 rs2472904 chr6:96874962 T/G cg06623918 chr6:96969491 KIAA0776 0.73 12.97 0.46 2.56e-34 Migraine;Coronary artery disease; BRCA cis rs7208859 0.673 rs9899943 chr17:29223925 G/A cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs28830936 1.000 rs2004162 chr15:41965542 A/G cg17847044 chr15:42102381 MAPKBP1 -0.32 -9.24 -0.34 3.5e-19 Diastolic blood pressure; BRCA cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg20476274 chr7:133979776 SLC35B4 -0.57 -15.82 -0.53 8.5e-48 Mean platelet volume; BRCA cis rs2249625 0.874 rs2463733 chr6:72882996 T/C cg18830697 chr6:72922368 RIMS1 -0.37 -7.86 -0.3 1.63e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA trans rs4718428 1.000 rs4718428 chr7:66421446 T/G cg18876405 chr7:65276391 NA 0.47 10.4 0.38 1.69e-23 Corneal structure; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg07308232 chr7:1071921 C7orf50 -0.43 -8.65 -0.32 4.03e-17 Longevity;Endometriosis; BRCA cis rs11758351 0.660 rs11755943 chr6:26211368 A/G cg01420254 chr6:26195488 NA 0.52 8.28 0.31 7.28e-16 Gout;Renal underexcretion gout; BRCA cis rs826838 1.000 rs10880914 chr12:38720543 C/T cg26384229 chr12:38710491 ALG10B 0.86 23.54 0.68 1.1e-88 Heart rate; BRCA cis rs2050392 0.517 rs2771242 chr10:30762973 C/T cg25182066 chr10:30743637 MAP3K8 -0.35 -8.28 -0.31 7.2e-16 Inflammatory bowel disease; BRCA cis rs10751667 0.666 rs7934963 chr11:957220 C/T cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 4.15e-15 Alzheimer's disease (late onset); BRCA cis rs1707322 1.000 rs11211228 chr1:46399840 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.79 0.39 4.55e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg03517284 chr6:25882590 NA 0.7 15.88 0.53 4.03e-48 Blood metabolite levels; BRCA cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg21918786 chr6:109611834 NA -0.49 -14.24 -0.49 3.85e-40 Reticulocyte fraction of red cells; BRCA cis rs1003719 0.679 rs1133001 chr21:38512956 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.4 -0.49 6.44e-41 Eye color traits; BRCA cis rs16958440 0.867 rs77599321 chr18:44689642 T/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA trans rs1941687 0.563 rs9947894 chr18:31328720 G/T cg27147174 chr7:100797783 AP1S1 0.46 9.08 0.34 1.33e-18 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs9443645 0.901 rs2050659 chr6:79734369 A/C cg05283184 chr6:79620031 NA -0.43 -10.88 -0.4 2.06e-25 Intelligence (multi-trait analysis); BRCA trans rs9987353 0.518 rs4841110 chr8:9086023 C/T cg08975724 chr8:8085496 FLJ10661 0.41 8.67 0.32 3.62e-17 Recombination measurement; BRCA trans rs2262909 0.719 rs12461632 chr19:22245089 G/A cg17074339 chr11:11642133 GALNTL4 0.43 8.2 0.31 1.35e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.74 -0.33 2e-17 Total body bone mineral density; BRCA trans rs1493916 0.805 rs1452648 chr18:31411003 G/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.52 -0.32 1.17e-16 Life satisfaction; BRCA cis rs59482735 1 rs59482735 chr9:123643426 T/TAA cg09419670 chr9:123605666 PSMD5;LOC253039 0.44 8.62 0.32 5.33e-17 Prostate-specific antigen levels; BRCA cis rs7809950 1.000 rs7793613 chr7:107250484 C/T cg23024343 chr7:107201750 COG5 -0.38 -8.67 -0.32 3.5e-17 Coronary artery disease; BRCA cis rs867371 1.000 rs9944197 chr15:82450602 G/A cg00614314 chr15:82944287 LOC80154 0.43 9.18 0.34 5.68e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg16606324 chr3:10149918 C3orf24 -0.46 -8.09 -0.3 3.03e-15 Alzheimer's disease; BRCA cis rs61931739 0.500 rs11053236 chr12:34507962 C/G cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.31e-22 Morning vs. evening chronotype; BRCA cis rs8180040 0.545 rs9311403 chr3:47138878 T/C cg16586182 chr3:47516702 SCAP -0.56 -12.48 -0.44 3.88e-32 Colorectal cancer; BRCA cis rs614226 1.000 rs541126 chr12:120972396 C/T cg27489772 chr12:121021490 NA -0.5 -8.65 -0.32 4e-17 Type 1 diabetes nephropathy; BRCA cis rs2066819 1.000 rs871130 chr12:56648777 A/G cg26734620 chr12:56694298 CS -0.85 -10.24 -0.38 6.72e-23 Psoriasis vulgaris; BRCA cis rs2625529 0.816 rs8025504 chr15:72294757 C/T cg16672083 chr15:72433130 SENP8 -0.85 -17.81 -0.58 6.64e-58 Red blood cell count; BRCA cis rs72772090 0.539 rs55773007 chr5:96124918 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.13 -0.43 1.28e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs514406 0.679 rs499239 chr1:53310594 A/G cg16325326 chr1:53192061 ZYG11B 0.57 12.72 0.45 3.27e-33 Monocyte count; BRCA cis rs4713118 0.662 rs149947 chr6:27972433 A/T cg02631126 chr6:28058918 ZSCAN12L1 0.26 7.81 0.3 2.28e-14 Parkinson's disease; BRCA cis rs4319547 0.656 rs3817011 chr12:122819566 C/T cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.58 -0.35 2.04e-20 Body mass index; BRCA cis rs875971 0.862 rs801206 chr7:66021966 C/G cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA cis rs965469 1.000 rs6037547 chr20:3299228 C/A cg25506879 chr20:3388711 C20orf194 -0.53 -10.29 -0.38 4.41e-23 IFN-related cytopenia; BRCA cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg00074818 chr8:8560427 CLDN23 0.36 7.86 0.3 1.6e-14 Obesity-related traits; BRCA cis rs4478858 0.775 rs6701667 chr1:31707971 A/C cg00250761 chr1:31883323 NA -0.34 -9.0 -0.34 2.47e-18 Alcohol dependence; BRCA cis rs798554 0.660 rs2644296 chr7:2859061 A/T cg18446336 chr7:2847575 GNA12 -0.33 -7.86 -0.3 1.68e-14 Height; BRCA cis rs6570726 0.791 rs6570695 chr6:145911286 C/A cg23711669 chr6:146136114 FBXO30 0.73 17.3 0.56 2.77e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.58 -0.32 7.19e-17 Total body bone mineral density; BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg04944784 chr2:26401820 FAM59B -0.85 -13.29 -0.47 9.7e-36 Gut microbiome composition (summer); BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg26314531 chr2:26401878 FAM59B -0.82 -15.28 -0.52 3.63e-45 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs6739061 chr2:26256147 C/T cg27170947 chr2:26402098 FAM59B -0.62 -10.77 -0.39 5.72e-25 Gut microbiome composition (summer); BRCA cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg10802521 chr3:52805072 NEK4 0.32 8.14 0.31 2.11e-15 Bipolar disorder; BRCA cis rs1707322 0.681 rs12048866 chr1:46117492 T/G cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6138458 0.961 rs227625 chr20:24911618 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.72 0.7 3.46e-95 Blood protein levels; BRCA cis rs651907 0.557 rs13099674 chr3:101489629 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 15.62 0.53 7.77e-47 Colorectal cancer; BRCA cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg23583168 chr7:148888333 NA -0.84 -17.85 -0.58 3.98e-58 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs734999 0.933 rs4648648 chr1:2512452 G/A cg18854424 chr1:2615690 NA 0.32 8.11 0.31 2.68e-15 Ulcerative colitis; BRCA cis rs4642101 0.662 rs3901664 chr3:12824660 T/C cg24848339 chr3:12840334 CAND2 0.49 13.41 0.47 2.65e-36 QRS complex (12-leadsum); BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs1829883 0.776 rs2511923 chr5:98721641 C/T cg08333243 chr5:99726346 NA 0.34 8.41 0.32 2.72e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs2762353 0.808 rs1183201 chr6:25823444 A/T cg03517284 chr6:25882590 NA -0.5 -11.34 -0.41 2.87e-27 Blood metabolite levels; BRCA cis rs12711979 0.509 rs13035992 chr2:3826597 G/A cg17052675 chr2:3827356 NA -0.7 -23.88 -0.69 1.5e-90 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs2836974 0.865 rs34778912 chr21:40667037 T/G cg17971929 chr21:40555470 PSMG1 0.77 17.64 0.57 4.64e-57 Cognitive function; BRCA cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg13256891 chr4:100009986 ADH5 0.52 9.85 0.36 2.07e-21 Alcohol dependence; BRCA cis rs10751667 1.000 rs11246359 chr11:967943 T/C ch.11.42038R chr11:967971 AP2A2 0.58 19.05 0.6 2.01e-64 Alzheimer's disease (late onset); BRCA cis rs17711722 0.523 rs313812 chr7:65505043 T/C cg11764359 chr7:65958608 NA -0.48 -9.35 -0.35 1.49e-19 Calcium levels; BRCA cis rs6665290 0.935 rs1929864 chr1:227195500 T/G cg10327440 chr1:227177885 CDC42BPA -1.15 -48.94 -0.89 2.43e-218 Myeloid white cell count; BRCA cis rs3784262 0.692 rs3784256 chr15:58263046 T/A cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.27 -0.38 5.28e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs10751667 0.714 rs7396700 chr11:963863 A/C cg10932868 chr11:921992 NA 0.49 12.4 0.44 8.43e-32 Alzheimer's disease (late onset); BRCA cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.76e-31 Blood protein levels; BRCA cis rs4242434 0.927 rs10095121 chr8:22538426 A/G cg03733263 chr8:22462867 KIAA1967 0.75 14.83 0.51 5.76e-43 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs6815814 0.950 rs5743595 chr4:38802644 A/G cg06935464 chr4:38784597 TLR10 0.51 8.46 0.32 1.8e-16 Breast cancer; BRCA cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.92 20.79 0.64 9.64e-74 Smoking behavior; BRCA cis rs17376456 0.825 rs6898842 chr5:93213221 T/C cg21475434 chr5:93447410 FAM172A 0.69 8.68 0.32 3.36e-17 Diabetic retinopathy; BRCA cis rs365132 1.000 rs353468 chr5:176445494 A/T cg16309518 chr5:176445507 NA -0.52 -13.24 -0.46 1.51e-35 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg03060546 chr3:49711283 APEH 0.55 9.22 0.34 4.32e-19 Menarche (age at onset); BRCA cis rs11098499 0.863 rs1480940 chr4:120457682 T/C cg09307838 chr4:120376055 NA 0.69 13.93 0.48 9.94e-39 Corneal astigmatism; BRCA cis rs3740540 0.507 rs897292 chr10:126290035 A/G cg04949429 chr10:126290192 LHPP 0.44 12.31 0.44 2.05e-31 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg04267008 chr7:1944627 MAD1L1 -0.5 -10.92 -0.4 1.42e-25 Bipolar disorder and schizophrenia; BRCA cis rs332507 0.830 rs3772786 chr3:124395250 A/C cg05980111 chr3:124395277 KALRN 0.37 8.46 0.32 1.83e-16 Plateletcrit; BRCA cis rs3796619 1.000 rs13146371 chr4:1082887 C/T cg27284194 chr4:1044797 NA 0.43 9.4 0.35 9.39e-20 Recombination rate (males); BRCA cis rs2882667 0.898 rs6890272 chr5:138371116 G/A cg04439458 chr5:138467593 SIL1 -0.32 -8.79 -0.33 1.36e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs56399783 0.901 rs6964740 chr7:2819656 C/G cg19731401 chr7:2775893 GNA12 0.45 8.02 0.3 5.2e-15 Childhood ear infection; BRCA cis rs7944584 0.545 rs7118178 chr11:47659135 G/A cg20307385 chr11:47447363 PSMC3 0.76 16.8 0.55 1.02e-52 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs13191362 1.000 rs1333963 chr6:163192571 A/G cg06582575 chr6:163149167 PACRG;PARK2 1.02 14.23 0.49 3.95e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs34172651 0.517 rs200526 chr16:24760511 C/T cg04756594 chr16:24857601 SLC5A11 -0.55 -12.3 -0.44 2.38e-31 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg04553112 chr3:125709451 NA -0.55 -8.27 -0.31 7.6e-16 Blood pressure (smoking interaction); BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg03709012 chr19:19516395 GATAD2A 0.68 14.22 0.49 4.51e-40 Tonsillectomy; BRCA trans rs9467711 0.606 rs9379875 chr6:26444732 C/T cg01620082 chr3:125678407 NA -0.65 -8.7 -0.33 2.73e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs67517081 1 rs67517081 chr16:30987380 GT/G cg02466173 chr16:30829666 NA 0.47 10.23 0.38 7.5e-23 Mean corpuscular hemoglobin; BRCA cis rs2204008 0.805 rs11180825 chr12:38242916 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.89 0.36 1.54e-21 Bladder cancer; BRCA cis rs7618501 0.633 rs4688689 chr3:50035542 C/T cg24308560 chr3:49941425 MST1R -0.39 -8.52 -0.32 1.12e-16 Intelligence (multi-trait analysis); BRCA cis rs2288073 0.801 rs10175668 chr2:24367275 G/A cg06627628 chr2:24431161 ITSN2 -0.54 -10.45 -0.38 1.04e-23 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7917772 0.536 rs11191361 chr10:104411958 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 16.0 0.53 9.98e-49 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1707322 0.964 rs785499 chr1:46592420 G/A cg06784218 chr1:46089804 CCDC17 -0.46 -10.53 -0.38 5.1900000000000004e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs5758511 0.689 rs17478227 chr22:42654327 C/G cg15128208 chr22:42549153 NA -0.5 -8.27 -0.31 7.57e-16 Birth weight; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.52 -10.97 -0.4 9.28e-26 Lymphocyte counts; BRCA cis rs9486719 1.000 rs11152969 chr6:96908712 A/C cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.66e-34 Migraine;Coronary artery disease; BRCA cis rs60843830 0.623 rs55932737 chr2:107543 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.48 9.14 0.34 8.42e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2580764 0.565 rs6760429 chr2:55228499 C/T cg09592903 chr2:55203963 RTN4 -0.41 -10.39 -0.38 1.86e-23 Mean platelet volume; BRCA cis rs4074536 0.574 rs10801967 chr1:116286983 A/G cg21648376 chr1:116311395 CASQ2 -0.48 -8.43 -0.32 2.24e-16 QRS duration; BRCA cis rs4243830 0.850 rs10779790 chr1:6608435 A/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.89 -17.65 -0.57 4.5e-57 Body mass index; BRCA cis rs35110281 0.641 rs9978858 chr21:45085552 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.03 -0.37 4.37e-22 Mean corpuscular volume; BRCA cis rs2617583 0.967 rs2550948 chr5:1450444 C/T cg07151155 chr5:1473589 LPCAT1 -0.42 -9.17 -0.34 6.22e-19 Breast cancer; BRCA cis rs4319547 0.695 rs4758645 chr12:122946487 G/A cg05707623 chr12:122985044 ZCCHC8 -0.39 -8.33 -0.31 4.88e-16 Body mass index; BRCA cis rs2204008 0.747 rs11514040 chr12:38201040 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg11644478 chr21:40555479 PSMG1 0.86 19.58 0.61 3.05e-67 Cognitive function; BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg13047869 chr3:10149882 C3orf24 0.6 12.81 0.45 1.29e-33 Alzheimer's disease; BRCA cis rs1401999 0.966 rs2037379 chr3:183650330 T/C cg20387954 chr3:183756860 HTR3D 0.45 9.97 0.37 7.24e-22 Anterior chamber depth; BRCA cis rs6435161 1.000 rs72926957 chr2:203487023 G/C cg18429434 chr2:203499731 FAM117B -0.44 -9.01 -0.34 2.28e-18 Total cholesterol levels; BRCA cis rs9463078 0.656 rs227843 chr6:44691703 A/G cg25276700 chr6:44698697 NA 0.37 8.12 0.31 2.48e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs67981189 0.593 rs221924 chr14:71580778 G/A cg15816911 chr14:71606274 NA -0.37 -8.31 -0.31 5.94e-16 Schizophrenia; BRCA cis rs7666738 0.716 rs28792413 chr4:99083707 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.35 0.35 1.42e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs10992471 0.528 rs10115290 chr9:95195858 G/A cg14631576 chr9:95140430 CENPP -0.35 -8.65 -0.32 4.13e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7772486 0.875 rs6913797 chr6:146413758 A/G cg05347473 chr6:146136440 FBXO30 0.4 7.91 0.3 1.1e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs72615157 0.628 rs7801070 chr7:99847147 T/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.57 9.92 0.37 1.12e-21 Lung function (FEV1/FVC); BRCA cis rs13191362 0.507 rs2849525 chr6:163126652 A/C cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -10.56 -0.39 4.01e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg21138405 chr5:131827807 IRF1 -0.4 -13.19 -0.46 2.66e-35 Asthma (sex interaction); BRCA trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.24 -19.67 -0.61 1.03e-67 Hemostatic factors and hematological phenotypes; BRCA cis rs1580019 0.961 rs4357201 chr7:32496333 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.08 0.54 4.26e-49 Cognitive ability; BRCA trans rs853679 0.769 rs17720293 chr6:28214698 C/T cg01620082 chr3:125678407 NA -0.74 -9.52 -0.35 3.59e-20 Depression; BRCA cis rs798554 0.731 rs2283779 chr7:2815140 G/A cg18446336 chr7:2847575 GNA12 -0.34 -7.85 -0.3 1.8e-14 Height; BRCA cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg13010199 chr12:38710504 ALG10B -0.42 -9.21 -0.34 4.52e-19 Morning vs. evening chronotype; BRCA cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg01475377 chr6:109611718 NA -0.52 -13.12 -0.46 5.69e-35 Reticulocyte fraction of red cells; BRCA cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg05890377 chr2:74357713 NA 0.48 11.74 0.42 6.09e-29 Gestational age at birth (maternal effect); BRCA cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg05872129 chr22:39784769 NA -0.57 -13.0 -0.46 1.81e-34 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.551 rs12978093 chr19:37584416 C/T cg18154014 chr19:37997991 ZNF793 0.53 8.7 0.33 2.75e-17 Coronary artery calcification; BRCA cis rs12497850 0.931 rs4974087 chr3:48919232 A/G cg07636037 chr3:49044803 WDR6 0.96 27.96 0.74 5.73e-113 Parkinson's disease; BRCA cis rs243505 0.762 rs933436 chr7:148487329 A/C cg09806900 chr7:148480153 CUL1 -0.54 -11.44 -0.41 1.09e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs514406 0.505 rs440871 chr1:53173052 C/T cg08859206 chr1:53392774 SCP2 -0.41 -8.91 -0.33 5.17e-18 Monocyte count; BRCA trans rs7647973 0.626 rs9829155 chr3:49817450 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.4 8.13 0.31 2.22e-15 Menarche (age at onset); BRCA cis rs10504229 0.683 rs67492041 chr8:58140077 G/A cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs2070488 0.745 rs7649153 chr3:38467753 T/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.54 12.06 0.43 2.64e-30 Electrocardiographic conduction measures; BRCA cis rs7945718 0.806 rs11022507 chr11:12829753 A/T cg25843174 chr11:12811716 TEAD1 0.24 9.01 0.34 2.39e-18 Educational attainment (years of education); BRCA cis rs6120849 0.617 rs12480442 chr20:33648388 C/G cg24642439 chr20:33292090 TP53INP2 0.61 10.47 0.38 8.5e-24 Protein C levels; BRCA cis rs56399783 0.901 rs73051469 chr7:2877811 A/G cg19731401 chr7:2775893 GNA12 0.54 8.25 0.31 9.25e-16 Childhood ear infection; BRCA cis rs35306767 0.903 rs12244253 chr10:889320 G/T cg20503657 chr10:835505 NA 1.05 18.71 0.59 1.3e-62 Eosinophil percentage of granulocytes; BRCA cis rs72781680 1.000 rs72781665 chr2:24223086 G/A cg08917208 chr2:24149416 ATAD2B 0.9 12.96 0.46 3e-34 Lymphocyte counts; BRCA cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg02551604 chr5:131831745 NA -0.4 -15.09 -0.51 3e-44 Asthma (sex interaction); BRCA cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg18252515 chr7:66147081 NA -0.35 -7.81 -0.3 2.44e-14 Aortic root size; BRCA cis rs11105298 0.891 rs11105302 chr12:89891366 A/G cg00757033 chr12:89920650 WDR51B -0.48 -9.82 -0.36 2.8e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs9325144 0.555 rs61929925 chr12:38698828 C/A cg23762105 chr12:34175262 ALG10 0.35 8.12 0.31 2.36e-15 Morning vs. evening chronotype; BRCA cis rs854765 0.547 rs4584886 chr17:17896205 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.61 18.64 0.59 2.88e-62 Total body bone mineral density; BRCA cis rs34779708 0.966 rs11010102 chr10:35411066 T/A cg03585969 chr10:35415529 CREM 0.5 10.46 0.38 9.82e-24 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6138458 1.000 rs227618 chr20:24909472 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.36 -0.31 3.88e-16 Blood protein levels; BRCA trans rs3733585 0.673 rs6814664 chr4:9956228 C/T cg26043149 chr18:55253948 FECH -0.37 -8.29 -0.31 6.69e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs4332037 0.539 rs55773130 chr7:2070554 T/C cg25206134 chr2:45395956 NA 0.51 8.66 0.32 3.71e-17 Bipolar disorder; BRCA cis rs7618501 0.633 rs9861216 chr3:50059339 A/G cg24110177 chr3:50126178 RBM5 0.41 11.45 0.41 9.98e-28 Intelligence (multi-trait analysis); BRCA cis rs873946 0.648 rs12766166 chr10:134556403 G/C cg27286337 chr10:134555280 INPP5A 0.62 10.3 0.38 4.07e-23 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6866344 0.661 rs72812606 chr5:178129094 A/T cg10224037 chr5:178157518 ZNF354A 0.76 15.97 0.53 1.55e-48 Neutrophil percentage of white cells; BRCA cis rs752010 0.905 rs2038977 chr1:42094659 A/G cg06885757 chr1:42089581 HIVEP3 0.29 10.16 0.37 1.4e-22 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs10504229 0.906 rs116341227 chr8:58190532 G/C cg14926445 chr8:58193284 C8orf71 -0.46 -8.88 -0.33 6.81e-18 Developmental language disorder (linguistic errors); BRCA cis rs2797160 0.967 rs1777224 chr6:126019527 T/C cg05901451 chr6:126070800 HEY2 0.42 10.27 0.38 5.34e-23 Endometrial cancer; BRCA cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.47 8.34 0.31 4.5e-16 Schizophrenia; BRCA cis rs7618501 0.633 rs6446189 chr3:50008566 A/G cg05623727 chr3:50126028 RBM5 0.43 10.1 0.37 2.27e-22 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs1577470 chr6:8462426 G/A cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.52e-19 Motion sickness; BRCA cis rs6598955 0.671 rs11579630 chr1:26612297 C/A cg04990556 chr1:26633338 UBXN11 0.55 8.73 0.33 2.24e-17 Obesity-related traits; BRCA cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg11663144 chr21:46675770 NA 0.53 11.38 0.41 1.88e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs12310956 0.532 rs35366144 chr12:33992000 C/G cg13010199 chr12:38710504 ALG10B 0.48 9.37 0.35 1.2e-19 Morning vs. evening chronotype; BRCA trans rs800082 0.698 rs800073 chr3:144347599 G/A cg24215973 chr2:240111563 HDAC4 -0.6 -14.58 -0.5 8.91e-42 Smoking behavior; BRCA cis rs9291683 0.546 rs13110307 chr4:10044364 T/C cg11266682 chr4:10021025 SLC2A9 0.45 11.99 0.43 4.9e-30 Bone mineral density; BRCA cis rs1707322 0.752 rs28568986 chr1:46207743 C/T cg03146154 chr1:46216737 IPP 0.53 11.75 0.42 5.61e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.862 rs6971059 chr7:66067032 A/G cg11764359 chr7:65958608 NA -0.75 -16.52 -0.55 2.69e-51 Aortic root size; BRCA cis rs4363385 0.747 rs946100 chr1:152971663 C/T cg25856811 chr1:152973957 SPRR3 0.33 8.72 0.33 2.39e-17 Inflammatory skin disease; BRCA cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg20887711 chr4:1340912 KIAA1530 -0.73 -15.52 -0.52 2.52e-46 Longevity; BRCA cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg06115741 chr20:33292138 TP53INP2 0.4 8.86 0.33 7.8e-18 Glomerular filtration rate (creatinine); BRCA cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg18305652 chr10:134549665 INPP5A -0.3 -8.73 -0.33 2.16e-17 Migraine; BRCA cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06544989 chr22:39130855 UNC84B 0.35 8.34 0.31 4.4e-16 Menopause (age at onset); BRCA cis rs911555 0.755 rs8016676 chr14:103904842 C/A cg24130564 chr14:104152367 KLC1 0.36 8.14 0.31 2.06e-15 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.904 rs10933161 chr2:227764872 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.39 -0.32 3.1e-16 Pulmonary function; BRCA trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.04e-18 Morning vs. evening chronotype; BRCA cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -9.79 -0.36 3.63e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs2797160 1.000 rs984040 chr6:126021277 A/G cg05901451 chr6:126070800 HEY2 0.38 9.38 0.35 1.11e-19 Endometrial cancer; BRCA cis rs11098499 0.754 rs12510269 chr4:120241646 A/G cg09307838 chr4:120376055 NA 0.63 13.82 0.48 3.27e-38 Corneal astigmatism; BRCA trans rs2204008 0.837 rs11180821 chr12:38242843 A/G cg06521331 chr12:34319734 NA -0.52 -9.81 -0.36 2.88e-21 Bladder cancer; BRCA cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg08085267 chr17:45401833 C17orf57 -0.63 -13.49 -0.47 1.08e-36 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4363385 0.747 rs6587716 chr1:152966705 C/T cg21543102 chr1:152974771 SPRR3 -0.3 -8.62 -0.32 5.43e-17 Inflammatory skin disease; BRCA cis rs10411936 0.750 rs8112401 chr19:16593012 C/T cg10248733 chr19:16607483 C19orf44;CALR3 0.45 9.66 0.36 1.07e-20 White blood cell count;Multiple sclerosis; BRCA trans rs208520 0.754 rs12204635 chr6:66740779 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.79 0.64 1.05e-73 Exhaled nitric oxide output; BRCA cis rs4285028 0.699 rs4676758 chr3:121583415 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.72 13.37 0.47 3.8e-36 Multiple sclerosis; BRCA cis rs965469 1.000 rs6051751 chr20:3310049 G/C cg25506879 chr20:3388711 C20orf194 -0.54 -10.53 -0.38 4.92e-24 IFN-related cytopenia; BRCA cis rs1003719 1.000 rs2835608 chr21:38493455 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 14.17 0.49 7.99e-40 Eye color traits; BRCA cis rs911186 0.786 rs13211901 chr6:27187612 G/A cg12292205 chr6:26970375 C6orf41 -0.64 -10.48 -0.38 7.73e-24 Autism spectrum disorder or schizophrenia; BRCA cis rs12893668 0.572 rs4900590 chr14:104146421 C/T cg26031613 chr14:104095156 KLC1 -0.53 -9.39 -0.35 1.05e-19 Reticulocyte count; BRCA cis rs34779708 0.931 rs34375045 chr10:35362356 A/C cg03585969 chr10:35415529 CREM 0.55 11.47 0.41 7.79e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3793683 0.825 rs3793674 chr10:134555773 C/T cg18305652 chr10:134549665 INPP5A -0.29 -8.37 -0.31 3.66e-16 Migraine; BRCA cis rs8062405 1.000 rs12446589 chr16:28870962 G/A cg09754948 chr16:28834200 ATXN2L 0.45 8.32 0.31 5.46e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs832540 0.656 rs6862118 chr5:56106474 G/A cg24531977 chr5:56204891 C5orf35 -0.54 -11.34 -0.41 2.69e-27 Coronary artery disease; BRCA cis rs1008375 0.966 rs2098152 chr4:17684392 G/T cg16339924 chr4:17578868 LAP3 0.6 14.59 0.5 8.4e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs34779708 0.966 rs17500582 chr10:35498788 T/A cg03585969 chr10:35415529 CREM 0.48 10.0 0.37 5.48e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6904897 0.538 rs4639353 chr6:135224328 A/G cg22676075 chr6:135203613 NA -0.62 -13.49 -0.47 1.12e-36 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg03188948 chr7:1209495 NA 0.51 9.44 0.35 6.94e-20 Longevity;Endometriosis; BRCA trans rs3942852 0.806 rs4752807 chr11:48128751 T/G cg15704280 chr7:45808275 SEPT13 -0.48 -9.28 -0.34 2.58e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.72 -0.36 6.32e-21 Developmental language disorder (linguistic errors); BRCA trans rs3960554 0.932 rs4728614 chr7:75841589 A/G cg19862616 chr7:65841803 NCRNA00174 -0.59 -11.74 -0.42 5.69e-29 Eotaxin levels; BRCA cis rs13191362 1.000 rs13214516 chr6:163121583 A/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.33 0.38 3.17e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg23285459 chr7:2802560 GNA12 -0.38 -9.66 -0.36 1.09e-20 Height; BRCA cis rs6142102 0.502 rs58393429 chr20:32545802 C/G cg24642439 chr20:33292090 TP53INP2 0.39 7.81 0.3 2.35e-14 Skin pigmentation; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg09177884 chr7:1199841 ZFAND2A -0.43 -9.2 -0.34 4.84e-19 Longevity;Endometriosis; BRCA cis rs12611088 0.600 rs2682578 chr19:44012880 A/G cg15012607 chr19:44012195 ETHE1 -0.34 -8.39 -0.31 3.19e-16 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg24642439 chr20:33292090 TP53INP2 -0.54 -11.82 -0.42 2.81e-29 Glomerular filtration rate (creatinine); BRCA cis rs6570726 0.967 rs403584 chr6:145807010 G/A cg23711669 chr6:146136114 FBXO30 0.62 14.31 0.49 1.7e-40 Lobe attachment (rater-scored or self-reported); BRCA trans rs9951602 0.512 rs3859325 chr18:76652175 A/G cg02800362 chr5:177631904 HNRNPAB 0.77 18.23 0.58 4.3e-60 Obesity-related traits; BRCA cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg00983440 chr10:79422392 NA -0.54 -10.13 -0.37 1.79e-22 Bone mineral density; BRCA cis rs7412746 0.524 rs58304714 chr1:150831561 T/A cg18016565 chr1:150552671 MCL1 0.35 8.02 0.3 5.05e-15 Melanoma; BRCA cis rs1707322 0.682 rs28508523 chr1:46189625 G/A cg03146154 chr1:46216737 IPP 0.47 10.4 0.38 1.62e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6089584 0.816 rs4134440 chr20:60624296 A/G cg13770153 chr20:60521292 NA -0.45 -9.82 -0.36 2.79e-21 Body mass index; BRCA cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg02503808 chr4:7069936 GRPEL1 0.8 18.6 0.59 4.7e-62 Monocyte percentage of white cells; BRCA cis rs6089584 0.854 rs6061407 chr20:60622048 A/C cg06108461 chr20:60628389 TAF4 -0.98 -22.13 -0.66 5.43e-81 Body mass index; BRCA cis rs4853036 0.629 rs10496171 chr2:70015181 A/G cg02498382 chr2:70120550 SNRNP27 0.43 7.98 0.3 6.94e-15 Colorectal or endometrial cancer; BRCA cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg04586622 chr2:25135609 ADCY3 0.4 9.23 0.34 3.91e-19 Body mass index; BRCA cis rs7949030 0.626 rs1061093 chr11:62334908 G/C cg13298116 chr11:62369859 EML3;MTA2 0.56 13.2 0.46 2.43e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs3780486 0.505 rs10758188 chr9:33123386 C/T cg04842962 chr6:43655489 MRPS18A -0.88 -23.94 -0.69 6.7e-91 IgG glycosylation; BRCA cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.68 0.42 1.1e-28 Homoarginine levels; BRCA cis rs11098499 0.780 rs7692994 chr4:120427489 C/A cg09307838 chr4:120376055 NA 0.67 14.71 0.5 2.2e-42 Corneal astigmatism; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg15242686 chr22:24348715 GSTTP1 0.36 9.0 0.34 2.49e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg22535103 chr8:58192502 C8orf71 -0.61 -13.3 -0.47 8.07e-36 Developmental language disorder (linguistic errors); BRCA cis rs10464366 0.510 rs62442212 chr7:39146896 A/C cg15212455 chr7:39170539 POU6F2 0.34 7.88 0.3 1.39e-14 IgG glycosylation; BRCA cis rs7520050 0.807 rs28647556 chr1:46206399 G/A cg24296786 chr1:45957014 TESK2 -0.47 -10.67 -0.39 1.44e-24 Red blood cell count;Reticulocyte count; BRCA cis rs1018836 0.923 rs13254212 chr8:91582355 T/C cg16814680 chr8:91681699 NA -0.58 -12.34 -0.44 1.51e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 1.000 rs3814486 chr8:58191226 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg06022373 chr22:39101656 GTPBP1 0.73 18.08 0.58 2.44e-59 Menopause (age at onset); BRCA cis rs7312933 0.703 rs2406567 chr12:42551479 G/C cg01256987 chr12:42539512 GXYLT1 -0.46 -9.2 -0.34 4.95e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs3857536 0.740 rs4710571 chr6:66890250 T/C cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.01e-18 Blood trace element (Cu levels); BRCA cis rs17345786 0.667 rs7622940 chr3:101133155 T/C cg12386194 chr3:101231763 SENP7 0.54 10.65 0.39 1.67e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg22903471 chr2:27725779 GCKR -0.37 -8.96 -0.33 3.41e-18 Total body bone mineral density; BRCA cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.77 12.48 0.44 3.86e-32 Mean platelet volume; BRCA cis rs6570726 0.791 rs392612 chr6:145881586 C/G cg23711669 chr6:146136114 FBXO30 -0.78 -18.57 -0.59 7.07e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs6456156 0.528 rs6936261 chr6:167469676 A/C cg07741184 chr6:167504864 NA 0.33 9.92 0.37 1.19e-21 Primary biliary cholangitis; BRCA trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21582582 chr3:182698605 DCUN1D1 0.39 10.11 0.37 2.08e-22 Intelligence (multi-trait analysis); BRCA cis rs6005807 0.719 rs2144922 chr22:28923317 A/G cg12565055 chr22:29076175 TTC28 0.43 8.37 0.31 3.65e-16 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs3813567 0.759 rs12595350 chr15:78953464 G/A cg04896959 chr15:78267971 NA -0.48 -8.57 -0.32 8.01e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.02 0.34 2.22e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg27347728 chr4:17578864 LAP3 0.44 8.62 0.32 5.41e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs4363385 0.747 rs2339493 chr1:152975277 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs4594175 0.886 rs11157801 chr14:51622918 C/T cg23942311 chr14:51606299 NA 0.34 8.63 0.32 5.05e-17 Cancer; BRCA trans rs970548 0.688 rs10900228 chr10:46082128 A/G cg20477318 chr10:51623047 TIMM23 0.44 7.93 0.3 9.99e-15 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; BRCA cis rs7267979 1.000 rs6076336 chr20:25319212 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.35 -9.78 -0.36 3.66e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7762018 1.000 rs17860606 chr6:170099561 G/A cg19338460 chr6:170058176 WDR27 -0.49 -8.58 -0.32 7.01e-17 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs7617773 0.746 rs7619865 chr3:48370580 G/A cg11946769 chr3:48343235 NME6 0.51 11.39 0.41 1.68e-27 Coronary artery disease; BRCA cis rs9287719 0.967 rs6432121 chr2:10753804 G/C cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.2e-15 Prostate cancer; BRCA cis rs12367572 0.965 rs1506676 chr12:45237401 T/C cg04608330 chr12:45269318 NELL2 -0.61 -12.8 -0.45 1.55e-33 Gut microbiome composition (summer); BRCA cis rs10782582 0.586 rs112368938 chr1:76336339 C/T cg03433033 chr1:76189801 ACADM -0.41 -8.33 -0.31 4.82e-16 Daytime sleep phenotypes; BRCA cis rs1401999 0.807 rs9869029 chr3:183735286 C/G cg20387954 chr3:183756860 HTR3D 0.47 10.38 0.38 1.94e-23 Anterior chamber depth; BRCA cis rs1551570 0.819 rs11666402 chr19:10219076 A/G cg16327482 chr19:10226339 EIF3G 0.38 9.77 0.36 4.23e-21 Narcolepsy; BRCA cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg02551604 chr5:131831745 NA 0.42 15.77 0.53 1.4e-47 Asthma (sex interaction); BRCA cis rs2180341 0.814 rs6940933 chr6:127732740 C/G cg27446573 chr6:127587934 RNF146 0.67 14.98 0.51 1.11e-43 Breast cancer; BRCA cis rs7809950 0.637 rs2701685 chr7:107299584 A/G cg23024343 chr7:107201750 COG5 0.4 8.92 0.33 4.91e-18 Coronary artery disease; BRCA cis rs3768617 0.510 rs2296294 chr1:183095596 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs10191773 0.589 rs72833410 chr2:113054119 G/A cg07905836 chr2:113190072 RGPD8;RGPD5 0.6 8.43 0.32 2.33e-16 Yeast infection; BRCA cis rs6831352 0.918 rs7694646 chr4:100059732 T/A cg12011299 chr4:100065546 ADH4 -0.51 -11.76 -0.42 5.05e-29 Alcohol dependence; BRCA trans rs3733585 0.699 rs6852441 chr4:9973744 C/T cg26043149 chr18:55253948 FECH -0.36 -8.05 -0.3 4.03e-15 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2898290 0.500 rs11998678 chr8:11830150 A/G cg14343924 chr8:8086146 FLJ10661 -0.4 -8.17 -0.31 1.62e-15 Systolic blood pressure; BRCA cis rs3849570 0.961 rs11915042 chr3:81834060 G/A cg07356753 chr3:81810745 GBE1 -0.47 -11.33 -0.41 3.13e-27 Waist circumference;Body mass index; BRCA cis rs10751667 0.600 rs10902264 chr11:1003523 G/A cg06064525 chr11:970664 AP2A2 -0.31 -9.0 -0.34 2.54e-18 Alzheimer's disease (late onset); BRCA cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.74e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.699 rs7677710 chr4:9969517 T/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.42 -0.38 1.36e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9381040 0.610 rs6940462 chr6:41020223 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.96 -0.37 8.08e-22 Alzheimer's disease (late onset); BRCA trans rs17685 0.753 rs11764129 chr7:75761890 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg03433033 chr1:76189801 ACADM 0.73 18.87 0.6 1.74e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4805272 0.512 rs4805278 chr19:29336664 C/T cg04546413 chr19:29218101 NA 0.5 8.64 0.32 4.33e-17 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs2832077 0.527 rs2142375 chr21:30223742 G/A cg08807101 chr21:30365312 RNF160 -0.55 -12.39 -0.44 9.7e-32 Cognitive test performance; BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg08219700 chr8:58056026 NA 0.54 8.77 0.33 1.6e-17 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.563 rs2505215 chr10:38481273 A/G cg23533926 chr12:111358616 MYL2 -0.43 -8.97 -0.33 3.19e-18 Extrinsic epigenetic age acceleration; BRCA cis rs4363385 0.747 rs4845504 chr1:152960043 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.81 -0.33 1.15e-17 Inflammatory skin disease; BRCA cis rs34779708 0.931 rs11593858 chr10:35381373 G/A cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.61e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs36051895 0.664 rs10117501 chr9:5094246 G/A cg02405213 chr9:5042618 JAK2 -0.51 -9.71 -0.36 6.97e-21 Pediatric autoimmune diseases; BRCA cis rs2625529 0.590 rs7183196 chr15:72544401 A/G cg16672083 chr15:72433130 SENP8 -0.69 -15.18 -0.51 1.18e-44 Red blood cell count; BRCA cis rs7246657 0.943 rs10405407 chr19:37839164 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA cis rs2731664 0.756 rs4976695 chr5:176862963 T/A cg23176889 chr5:176863531 GRK6 -0.59 -15.47 -0.52 4.3e-46 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.745 rs8189516 chr12:38239084 C/T cg06521331 chr12:34319734 NA -0.49 -9.11 -0.34 1.06e-18 Bladder cancer; BRCA cis rs921968 0.541 rs6710383 chr2:219359685 T/G cg10223061 chr2:219282414 VIL1 -0.27 -7.92 -0.3 1.04e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs7818345 0.845 rs17407039 chr8:19268056 G/A cg11303988 chr8:19266685 CSGALNACT1 0.33 8.25 0.31 8.86e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg15112475 chr7:1198522 ZFAND2A -0.41 -7.97 -0.3 7.08e-15 Bronchopulmonary dysplasia; BRCA cis rs61656020 1 rs61656020 chr16:1882221 C/G cg00046913 chr16:1877150 HAGH;FAHD1 -0.6 -10.05 -0.37 3.56e-22 Ankle injury; BRCA cis rs910316 0.967 rs8007539 chr14:75664953 T/C cg23033748 chr14:75592666 NEK9 -0.4 -9.61 -0.36 1.68e-20 Height; BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg12311346 chr5:56204834 C5orf35 -0.78 -14.61 -0.5 6.65e-42 Initial pursuit acceleration; BRCA cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg05564831 chr3:52568323 NT5DC2 0.34 8.05 0.3 3.96e-15 Electroencephalogram traits; BRCA cis rs6570726 0.935 rs1883406 chr6:145823205 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.753 rs11097607 chr4:99011640 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.84e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.5 0.38 6.63e-24 Motion sickness; BRCA cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg06582575 chr6:163149167 PACRG;PARK2 -0.51 -9.49 -0.35 4.57e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.54 7.98 0.3 6.89e-15 Cerebrospinal P-tau181p levels; BRCA cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg02659138 chr7:134003124 SLC35B4 0.33 10.18 0.37 1.2e-22 Mean platelet volume; BRCA cis rs9463078 0.665 rs4714816 chr6:44715168 T/C cg25276700 chr6:44698697 NA 0.41 9.56 0.35 2.55e-20 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.42 0.47 2.35e-36 Colorectal cancer; BRCA cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg15839431 chr19:19639596 YJEFN3 -0.43 -9.37 -0.35 1.23e-19 Bipolar disorder; BRCA trans rs7618501 0.633 rs55751738 chr3:49972101 A/G cg21659725 chr3:3221576 CRBN 0.46 11.56 0.42 3.34e-28 Intelligence (multi-trait analysis); BRCA cis rs2072499 0.695 rs112223391 chr1:156156094 G/A cg25208724 chr1:156163844 SLC25A44 0.88 17.72 0.57 1.93e-57 Testicular germ cell tumor; BRCA cis rs6912958 0.512 rs910563 chr6:88058885 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.55 11.85 0.42 1.95e-29 Monocyte percentage of white cells; BRCA cis rs2180341 1.000 rs2326567 chr6:127606160 G/A cg27446573 chr6:127587934 RNF146 0.88 20.81 0.64 8.36e-74 Breast cancer; BRCA cis rs1568889 0.775 rs35243076 chr11:28250618 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.59 0.63 1.26e-72 Bipolar disorder; BRCA cis rs2051211 0.947 rs60479981 chr3:38568611 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.52 -10.05 -0.37 3.65e-22 QRS duration; BRCA trans rs6479901 0.557 rs4746125 chr10:65152885 G/A cg14819942 chr15:35414228 NA 0.3 7.93 0.3 1.01e-14 Intelligence (multi-trait analysis); BRCA cis rs6543140 0.964 rs2160200 chr2:103033963 G/T cg04239558 chr2:103089729 SLC9A4 0.33 9.25 0.34 3.24e-19 Blood protein levels; BRCA cis rs67981189 0.574 rs4467005 chr14:71498656 C/T cg15816911 chr14:71606274 NA 0.37 8.34 0.31 4.55e-16 Schizophrenia; BRCA cis rs273218 1.000 rs156440 chr5:53373656 A/T ch.5.1024479R chr5:53302184 ARL15 0.43 8.89 0.33 6.38e-18 Migraine; BRCA cis rs9653442 0.835 rs11694875 chr2:100732845 A/G cg22139774 chr2:100720529 AFF3 0.32 8.91 0.33 5.41e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs1843834 0.539 rs2068244 chr2:225440011 A/G cg22509189 chr2:225307070 NA 0.43 9.1 0.34 1.13e-18 IgE levels in asthmatics (D.p. specific); BRCA cis rs586533 0.881 rs590114 chr11:99500472 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6484504 0.652 rs578666 chr11:31404484 C/T cg14844989 chr11:31128820 NA 0.44 9.39 0.35 1.05e-19 Red blood cell count; BRCA cis rs1691799 0.899 rs903590 chr12:66745777 C/G cg16791601 chr12:66731901 HELB -0.63 -17.02 -0.56 7.32e-54 White blood cell count (basophil); BRCA cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg07636037 chr3:49044803 WDR6 0.55 8.74 0.33 2.09e-17 Menarche (age at onset); BRCA cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg23422044 chr7:1970798 MAD1L1 -0.59 -10.62 -0.39 2.3e-24 Bipolar disorder; BRCA cis rs11098499 0.954 rs17005535 chr4:120411562 C/T cg09307838 chr4:120376055 NA 0.74 16.0 0.53 1.01e-48 Corneal astigmatism; BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.35 8.22 0.31 1.13e-15 Tonsillectomy; BRCA cis rs4363385 0.818 rs572821 chr1:153008276 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs17376456 0.825 rs74825443 chr5:93254973 T/C cg25358565 chr5:93447407 FAM172A 1.17 18.43 0.59 3.64e-61 Diabetic retinopathy; BRCA cis rs6061231 1.000 rs11696991 chr20:60959694 G/T cg06026331 chr20:60912101 LAMA5 0.4 8.16 0.31 1.83e-15 Colorectal cancer; BRCA cis rs6964587 0.692 rs4729021 chr7:91758422 C/A cg17063962 chr7:91808500 NA 0.56 12.7 0.45 3.95e-33 Breast cancer; BRCA trans rs11098499 0.866 rs12374244 chr4:120281972 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg23583168 chr7:148888333 NA -0.78 -17.93 -0.58 1.61e-58 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2549003 1.000 rs2548997 chr5:131835395 C/T cg02551604 chr5:131831745 NA 0.39 13.99 0.48 5.63e-39 Asthma (sex interaction); BRCA cis rs12497850 0.931 rs9682444 chr3:48852639 A/G cg06212747 chr3:49208901 KLHDC8B 0.47 9.4 0.35 9.73e-20 Parkinson's disease; BRCA cis rs9393777 0.623 rs9358946 chr6:26478927 G/A cg12826209 chr6:26865740 GUSBL1 0.56 9.23 0.34 3.92e-19 Intelligence (multi-trait analysis); BRCA cis rs4690686 0.500 rs7657249 chr4:177275198 A/G cg17059388 chr4:177262070 NA 0.54 11.13 0.4 2.02e-26 Essential tremor; BRCA cis rs7613875 0.620 rs17657688 chr3:50033228 C/T cg14019146 chr3:50243930 SLC38A3 0.36 8.9 0.33 5.88e-18 Body mass index; BRCA cis rs344364 0.511 rs1657134 chr16:1953127 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.53 -9.49 -0.35 4.41e-20 Glomerular filtration rate in chronic kidney disease; BRCA trans rs11098499 0.863 rs13140391 chr4:120503437 A/G cg25214090 chr10:38739885 LOC399744 0.54 11.89 0.43 1.43e-29 Corneal astigmatism; BRCA cis rs2243480 1.000 rs313820 chr7:65574466 A/C cg18252515 chr7:66147081 NA -1.05 -15.27 -0.52 4.34e-45 Diabetic kidney disease; BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22029157 chr1:209979665 IRF6 0.59 17.96 0.58 1.01e-58 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs796364 1.000 rs281785 chr2:200749566 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 12.06 0.43 2.49e-30 Schizophrenia; BRCA cis rs12893668 0.572 rs2273175 chr14:104160141 T/C cg24130564 chr14:104152367 KLC1 -0.41 -8.9 -0.33 5.54e-18 Reticulocyte count; BRCA trans rs3733585 0.673 rs4312757 chr4:9956145 T/A cg26043149 chr18:55253948 FECH -0.37 -8.29 -0.31 6.69e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg27398817 chr8:82754497 SNX16 -0.36 -8.17 -0.31 1.6e-15 Diastolic blood pressure; BRCA cis rs2204008 0.577 rs2623049 chr12:38018831 G/A cg26384229 chr12:38710491 ALG10B -0.57 -13.23 -0.46 1.75e-35 Bladder cancer; BRCA cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg25358565 chr5:93447407 FAM172A 1.14 18.39 0.59 6.32e-61 Diabetic retinopathy; BRCA cis rs992157 0.804 rs7559525 chr2:219150307 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.36 -0.41 2.36e-27 Colorectal cancer; BRCA cis rs68170813 0.559 rs12537011 chr7:107027833 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.66 -0.32 3.93e-17 Coronary artery disease; BRCA trans rs7200543 1.000 rs3803575 chr16:15138447 T/C cg24683922 chr1:11983373 KIAA2013 -0.37 -8.5 -0.32 1.34e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs10463316 0.817 rs906679 chr5:150779302 T/A cg03212797 chr5:150827313 SLC36A1 -0.4 -7.97 -0.3 7.39e-15 Metabolite levels (Pyroglutamine); BRCA cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg26384229 chr12:38710491 ALG10B 0.69 15.89 0.53 3.53e-48 Bladder cancer; BRCA cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA cis rs9393777 0.513 rs9295702 chr6:26634040 T/C cg12292205 chr6:26970375 C6orf41 -0.49 -8.27 -0.31 7.96e-16 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs35909098 chr21:32021649 C/T cg16431978 chr21:31797932 KRTAP13-3 0.36 9.11 0.34 1.05e-18 HDL cholesterol; BRCA cis rs3008870 1.000 rs2065000 chr1:67468124 G/C cg08660285 chr1:67390436 MIER1;WDR78 -0.95 -21.48 -0.65 1.76e-77 Lymphocyte percentage of white cells; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.93e-19 Lymphocyte counts; BRCA cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg22535103 chr8:58192502 C8orf71 -0.6 -13.05 -0.46 1.1e-34 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.840 rs3892363 chr12:38479487 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Bladder cancer; BRCA cis rs2505998 0.833 rs2505533 chr10:43594453 A/G cg15436174 chr10:43711423 RASGEF1A -0.42 -8.35 -0.31 4.2e-16 Hirschsprung disease; BRCA cis rs698833 0.518 rs7562945 chr2:44552772 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.16 0.31 1.83e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg13010199 chr12:38710504 ALG10B 0.43 9.16 0.34 6.75e-19 Morning vs. evening chronotype; BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg03609598 chr5:56110824 MAP3K1 -0.47 -8.19 -0.31 1.42e-15 Initial pursuit acceleration; BRCA cis rs7772486 0.688 rs1884364 chr6:146337817 C/G cg13319975 chr6:146136371 FBXO30 -0.48 -10.7 -0.39 1.11e-24 Lobe attachment (rater-scored or self-reported); BRCA cis rs1448094 0.511 rs17280643 chr12:86210154 C/T cg19622623 chr12:86230825 RASSF9 0.31 8.6 0.32 6.38e-17 Major depressive disorder; BRCA cis rs589448 0.967 rs2617835 chr12:69753420 C/A cg20891283 chr12:69753455 YEATS4 0.84 28.41 0.75 1.93e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs4588572 0.643 rs1035950 chr5:77785858 G/A cg11547950 chr5:77652471 NA -0.48 -8.42 -0.32 2.55e-16 Triglycerides; BRCA cis rs17604090 0.938 rs115369413 chr7:29685040 T/G cg19413766 chr7:29689036 LOC646762 -0.55 -8.59 -0.32 6.49e-17 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs12477438 0.798 rs12473029 chr2:99637961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -19.27 -0.61 1.44e-65 Chronic sinus infection; BRCA cis rs8180040 0.966 rs11130129 chr3:47489885 G/C cg27129171 chr3:47204927 SETD2 -0.68 -15.95 -0.53 1.86e-48 Colorectal cancer; BRCA cis rs300703 0.515 rs424292 chr2:191931 C/T cg21211680 chr2:198530 NA -0.39 -8.82 -0.33 1.11e-17 Blood protein levels; BRCA cis rs8177253 0.606 rs6787177 chr3:133450720 C/T cg12373951 chr3:133503437 NA 0.34 8.15 0.31 1.95e-15 Iron status biomarkers; BRCA cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.71 10.9 0.4 1.69e-25 Lung function (FEV1/FVC); BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs61931739 0.534 rs2087128 chr12:34000173 T/C cg06521331 chr12:34319734 NA -0.54 -10.83 -0.39 3.27e-25 Morning vs. evening chronotype; BRCA cis rs57024841 0.819 rs11145948 chr9:139857912 C/T cg00693599 chr9:139836323 FBXW5 -0.34 -8.18 -0.31 1.53e-15 Beta-trace protein levels; BRCA cis rs754466 0.606 rs55854323 chr10:79589904 C/T cg17075019 chr10:79541650 NA -0.81 -19.61 -0.61 2.18e-67 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs7939886 0.920 rs11227321 chr11:55904828 A/G cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs4268898 0.516 rs7597149 chr2:24371962 C/T cg06627628 chr2:24431161 ITSN2 0.42 8.68 0.32 3.17e-17 Asthma; BRCA cis rs10504229 0.683 rs67048677 chr8:58140023 C/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs709400 0.628 rs4906321 chr14:103878882 C/T cg12935359 chr14:103987150 CKB -0.53 -12.64 -0.45 7.42e-33 Body mass index; BRCA cis rs1018836 0.847 rs4735225 chr8:91569100 G/C cg16814680 chr8:91681699 NA -0.64 -14.24 -0.49 3.76e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9467160 0.651 rs7755403 chr6:24453447 C/G cg20631270 chr6:24437470 GPLD1 0.43 8.63 0.32 4.88e-17 Liver enzyme levels; BRCA cis rs6088580 0.634 rs6142157 chr20:32984172 C/G cg06115741 chr20:33292138 TP53INP2 -0.37 -8.14 -0.31 2.05e-15 Glomerular filtration rate (creatinine); BRCA cis rs2425143 0.908 rs6060625 chr20:34414318 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -8.3 -0.31 5.99e-16 Blood protein levels; BRCA cis rs7959452 0.535 rs7133487 chr12:69774377 G/A cg14784868 chr12:69753453 YEATS4 0.66 19.09 0.6 1.27e-64 Blood protein levels; BRCA cis rs589448 0.872 rs315111 chr12:69784695 G/A cg20891283 chr12:69753455 YEATS4 0.83 27.97 0.74 5.23e-113 Cerebrospinal fluid biomarker levels; BRCA cis rs875971 0.895 rs10447522 chr7:65796074 A/G cg11764359 chr7:65958608 NA -0.76 -16.74 -0.55 1.98e-52 Aortic root size; BRCA cis rs17270561 0.609 rs2275905 chr6:25768106 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg21784768 chr11:537496 LRRC56 -0.64 -8.28 -0.31 7.08e-16 Body mass index; BRCA cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg10560079 chr2:191398806 TMEM194B -0.72 -12.94 -0.46 3.61e-34 Diastolic blood pressure; BRCA cis rs208520 0.874 rs208514 chr6:66945520 G/A cg07460842 chr6:66804631 NA -0.82 -14.74 -0.5 1.51e-42 Exhaled nitric oxide output; BRCA cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg00074818 chr8:8560427 CLDN23 0.39 8.45 0.32 1.96e-16 Obesity-related traits; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11676348 0.783 rs4674252 chr2:218984478 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.93 -0.3 9.75e-15 Ulcerative colitis; BRCA cis rs17253792 0.822 rs10150498 chr14:56064124 G/T cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs921968 0.529 rs6729341 chr2:219611434 T/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.12 -0.4 2.15e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg13319975 chr6:146136371 FBXO30 -0.35 -8.09 -0.3 3.11e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg19077165 chr18:44547161 KATNAL2 0.62 14.21 0.49 4.86e-40 Personality dimensions; BRCA cis rs6005807 0.640 rs73432205 chr22:29028132 C/T cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.35 0.38 2.49e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1865760 0.588 rs9467658 chr6:26010881 T/G cg17691542 chr6:26056736 HIST1H1C 0.53 11.21 0.41 9.28e-27 Height; BRCA cis rs3857067 0.806 rs6857967 chr4:95112303 C/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.25 -0.34 3.46e-19 QT interval; BRCA cis rs10751667 0.621 rs10794353 chr11:948740 A/G ch.11.42038R chr11:967971 AP2A2 0.5 15.89 0.53 3.66e-48 Alzheimer's disease (late onset); BRCA cis rs4363385 0.747 rs2075739 chr1:152975495 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg13319975 chr6:146136371 FBXO30 -0.53 -11.77 -0.42 4.25e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs6952809 0.532 rs2023969 chr7:2449980 T/C cg05083358 chr7:2394359 EIF3B -0.5 -8.11 -0.31 2.52e-15 Multiple sclerosis; BRCA cis rs7618501 0.602 rs2526754 chr3:50125996 G/A cg24110177 chr3:50126178 RBM5 0.4 11.1 0.4 2.55e-26 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs7767780 chr6:8453462 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.32 0.49 1.55e-40 Motion sickness; BRCA cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg01028140 chr2:1542097 TPO -0.7 -13.1 -0.46 6.38e-35 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9325144 0.555 rs4882279 chr12:38688918 C/A cg26384229 chr12:38710491 ALG10B 0.51 13.56 0.47 5.65e-37 Morning vs. evening chronotype; BRCA cis rs1127311 0.875 rs9427102 chr1:154586957 A/G cg17218026 chr1:154582156 ADAR 0.29 8.58 0.32 7.16e-17 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs1577917 1.000 rs13196930 chr6:86652245 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -14.44 -0.5 4.25e-41 Response to antipsychotic treatment; BRCA cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 3.81e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs2014572 0.901 rs35658377 chr19:57755627 T/G cg24459738 chr19:57751996 ZNF805 -0.34 -8.09 -0.3 2.94e-15 Hyperactive-impulsive symptoms; BRCA cis rs7772486 0.875 rs2207785 chr6:146332784 T/G cg23711669 chr6:146136114 FBXO30 0.67 15.49 0.52 3.54e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs778371 1.000 rs778371 chr2:233743109 A/G cg08000102 chr2:233561755 GIGYF2 -0.74 -15.56 -0.52 1.5e-46 Schizophrenia; BRCA cis rs6723226 0.572 rs176404 chr2:32638846 T/C cg02381751 chr2:32503542 YIPF4 -0.46 -9.65 -0.36 1.17e-20 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg24549020 chr5:56110836 MAP3K1 0.66 13.4 0.47 3.01e-36 Initial pursuit acceleration; BRCA cis rs4409675 0.576 rs10751724 chr1:28215631 C/T cg23691781 chr1:28212827 C1orf38 0.32 11.12 0.4 2.22e-26 Corneal astigmatism; BRCA trans rs7395662 0.591 rs7482521 chr11:48609735 G/A cg00717180 chr2:96193071 NA -0.38 -10.34 -0.38 2.9e-23 HDL cholesterol; BRCA trans rs2262909 0.962 rs17459246 chr19:22278121 T/C cg17074339 chr11:11642133 GALNTL4 0.44 8.52 0.32 1.19e-16 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.81 -0.33 1.2e-17 Intelligence (multi-trait analysis); BRCA cis rs6430585 0.591 rs1374330 chr2:136420908 A/C cg07169764 chr2:136633963 MCM6 1.13 20.13 0.62 3.73e-70 Corneal structure; BRCA cis rs2171564 0.727 rs6788567 chr3:112437047 A/C cg06685282 chr3:112453648 NA -0.37 -8.78 -0.33 1.5e-17 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg08999081 chr20:33150536 PIGU 0.45 12.12 0.43 1.39e-30 Coronary artery disease; BRCA cis rs9323205 0.906 rs11629336 chr14:51686620 A/C cg23942311 chr14:51606299 NA 0.42 8.68 0.32 3.26e-17 Cancer; BRCA cis rs698813 0.604 rs58667148 chr2:44481443 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.55 0.32 8.9e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs6120849 0.573 rs3746429 chr20:33703607 A/G cg24642439 chr20:33292090 TP53INP2 -0.58 -8.52 -0.32 1.11e-16 Protein C levels; BRCA cis rs8114671 0.562 rs4911163 chr20:33470694 C/T cg07148914 chr20:33460835 GGT7 0.37 8.48 0.32 1.62e-16 Height; BRCA trans rs2262909 0.962 rs411020 chr19:22231102 G/A cg17074339 chr11:11642133 GALNTL4 -0.41 -7.98 -0.3 6.96e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs6964587 1.000 rs2299238 chr7:91654517 G/A cg17063962 chr7:91808500 NA 0.52 12.41 0.44 7.57e-32 Breast cancer; BRCA cis rs6835098 0.962 rs4419455 chr4:174083622 C/T cg27433088 chr4:174089019 GALNT7 -0.36 -9.93 -0.37 1.08e-21 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs9814567 1.000 rs6787371 chr3:134254991 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.57 -0.61 3.67e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg25754956 chr12:51612065 POU6F1 0.85 16.56 0.55 1.6e-51 Cisplatin-induced ototoxicity; BRCA cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg10057126 chr4:77819792 ANKRD56 0.65 14.93 0.51 1.94e-43 Emphysema distribution in smoking; BRCA cis rs13102973 0.899 rs10213137 chr4:135900543 T/C cg14419869 chr4:135874104 NA -0.52 -10.64 -0.39 1.82e-24 Subjective well-being; BRCA cis rs7412746 0.587 rs11204722 chr1:150730184 A/C cg18016565 chr1:150552671 MCL1 -0.35 -8.17 -0.31 1.66e-15 Melanoma; BRCA cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs2455601 0.786 rs10279 chr11:8969309 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -7.83 -0.3 1.97e-14 Schizophrenia; BRCA cis rs2012796 1.000 rs7153469 chr14:81820979 T/G cg02996355 chr14:81879375 NA 0.51 10.03 0.37 4.53e-22 Night sleep phenotypes; BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg26516362 chr5:178986906 RUFY1 0.43 11.13 0.4 2.05e-26 Lung cancer; BRCA cis rs2153535 0.580 rs2184583 chr6:8447808 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA trans rs11039798 0.764 rs76882342 chr11:48939091 A/T cg15704280 chr7:45808275 SEPT13 0.6 8.89 0.33 6.42e-18 Axial length; BRCA cis rs3741404 0.620 rs12787945 chr11:63977546 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.59 0.5 7.84e-42 Platelet count; BRCA cis rs3749237 1.000 rs3749237 chr3:49770032 C/T cg07636037 chr3:49044803 WDR6 0.41 8.41 0.32 2.69e-16 Resting heart rate; BRCA cis rs79839061 0.563 rs55728587 chr4:843674 G/A cg07828340 chr4:882639 GAK 1.01 11.71 0.42 7.8e-29 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs2420612 chr7:66001812 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.54 9.98 0.37 6.66e-22 Aortic root size; BRCA cis rs7666738 0.800 rs12163918 chr4:98835794 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.49 0.5 2.33e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs910316 1.000 rs175449 chr14:75590846 A/T cg11812906 chr14:75593930 NEK9 -0.62 -14.2 -0.49 5.61e-40 Height; BRCA cis rs10493773 0.775 rs11161649 chr1:86165446 A/C cg17807903 chr1:86174739 ZNHIT6 -0.45 -10.54 -0.38 4.83e-24 Urate levels in overweight individuals; BRCA cis rs2370759 1.000 rs7910776 chr10:32639093 C/T cg01819863 chr10:32635814 EPC1 1.15 18.71 0.6 1.22e-62 Sexual dysfunction (female); BRCA trans rs11577318 0.853 rs11803933 chr1:26629465 G/C cg07461501 chr17:79650226 HGS;ARL16 0.4 10.09 0.37 2.53e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg22800045 chr5:56110881 MAP3K1 0.56 10.52 0.38 5.82e-24 Initial pursuit acceleration; BRCA cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.71 18.31 0.59 1.63e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs4076764 0.958 rs6691127 chr1:163384831 T/C cg06092702 chr1:163392909 NA -0.35 -9.45 -0.35 6.23e-20 Motion sickness; BRCA cis rs9318086 0.687 rs9507182 chr13:24442365 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.31 9.08 0.34 1.37e-18 Myopia (pathological); BRCA cis rs11711311 1.000 rs9827682 chr3:113450251 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.35 9.12 0.34 9.44e-19 IgG glycosylation; BRCA cis rs13095912 0.962 rs7644758 chr3:185328197 G/T cg11274856 chr3:185301563 NA -0.36 -8.84 -0.33 9.31e-18 Systolic blood pressure; BRCA cis rs9325144 0.647 rs870431 chr12:38953073 T/C cg26384229 chr12:38710491 ALG10B -0.49 -11.7 -0.42 8.57e-29 Morning vs. evening chronotype; BRCA trans rs6598955 0.671 rs59143843 chr1:26641595 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.67 -0.53 4.47e-47 Obesity-related traits; BRCA cis rs1215050 0.765 rs588851 chr4:98678247 C/T cg05340658 chr4:99064831 C4orf37 0.44 10.07 0.37 3.12e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7809950 0.559 rs2248465 chr7:107303628 C/T cg23024343 chr7:107201750 COG5 0.38 8.43 0.32 2.27e-16 Coronary artery disease; BRCA cis rs60012524 1 rs60012524 chr2:99559117 T/C cg08885076 chr2:99613938 TSGA10 -0.52 -9.59 -0.35 1.99e-20 Chronic sinus infection; BRCA cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg13175981 chr1:150552382 MCL1 0.54 11.84 0.42 2.18e-29 Tonsillectomy; BRCA cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.67 0.5 3.39e-42 Colorectal cancer; BRCA cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg10932868 chr11:921992 NA 0.38 9.12 0.34 9.94e-19 Alzheimer's disease (late onset); BRCA cis rs4803468 1.000 rs166925 chr19:41926098 T/C cg09537434 chr19:41945824 ATP5SL -1.0 -23.64 -0.68 3e-89 Height; BRCA cis rs17345786 0.911 rs10936707 chr3:101324063 G/A cg12386194 chr3:101231763 SENP7 0.62 12.27 0.44 3.04e-31 Colonoscopy-negative controls vs population controls; BRCA cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg17420585 chr12:42539391 GXYLT1 -0.48 -10.33 -0.38 3.19e-23 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs1478897 0.898 rs2248932 chr8:11391650 A/G cg06636001 chr8:8085503 FLJ10661 -0.38 -7.85 -0.3 1.76e-14 Systemic lupus erythematosus; BRCA cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg27446573 chr6:127587934 RNF146 0.88 20.44 0.63 7.82e-72 Breast cancer; BRCA cis rs2842992 0.724 rs9347340 chr6:160188891 C/T cg16489826 chr6:160211363 TCP1;MRPL18 -0.66 -15.16 -0.51 1.45e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs7647973 0.626 rs7649428 chr3:49868876 A/T cg03060546 chr3:49711283 APEH -0.59 -10.38 -0.38 1.9e-23 Menarche (age at onset); BRCA cis rs9463078 0.764 rs9367208 chr6:44830180 G/A cg25276700 chr6:44698697 NA -0.36 -8.32 -0.31 5.53e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2180341 0.960 rs9375503 chr6:127677071 T/C cg24812749 chr6:127587940 RNF146 0.87 20.07 0.62 7.99e-70 Breast cancer; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg08470875 chr2:26401718 FAM59B 0.76 11.99 0.43 4.93e-30 Gut microbiome composition (summer); BRCA trans rs853679 0.546 rs35017208 chr6:28345282 C/T cg06606381 chr12:133084897 FBRSL1 -0.9 -8.85 -0.33 8.67e-18 Depression; BRCA cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.58 0.59 5.9e-62 Schizophrenia; BRCA cis rs11792861 0.926 rs12683988 chr9:111867290 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.05 0.3 3.95e-15 Menarche (age at onset); BRCA cis rs4727443 0.866 rs13243708 chr7:99616291 T/C cg22004693 chr7:99632812 ZKSCAN1 0.41 9.12 0.34 9.64e-19 Interstitial lung disease; BRCA cis rs6430585 0.528 rs75753154 chr2:136665711 T/C cg07169764 chr2:136633963 MCM6 1.27 26.71 0.73 3.86e-106 Corneal structure; BRCA trans rs6582630 0.555 rs10880607 chr12:38508184 A/G cg06521331 chr12:34319734 NA -0.51 -9.35 -0.35 1.41e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs6952808 0.692 rs11765549 chr7:2027311 G/T cg03354898 chr7:1950403 MAD1L1 -0.39 -8.19 -0.31 1.42e-15 Bipolar disorder and schizophrenia; BRCA cis rs7772486 0.840 rs2474355 chr6:146312540 C/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.22 -0.31 1.1e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs1933383 chr1:152963468 C/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.65 -0.32 4.05e-17 Inflammatory skin disease; BRCA cis rs7267979 1.000 rs6083862 chr20:25411086 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.72 -0.33 2.31e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.91 0.37 1.24e-21 Bladder cancer; BRCA cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg26031613 chr14:104095156 KLC1 -0.45 -8.85 -0.33 8.71e-18 Schizophrenia; BRCA trans rs11039798 1.000 rs115429994 chr11:48761183 C/G cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs4727027 0.737 rs10278971 chr7:148780659 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.46 9.73 0.36 5.94e-21 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg03929089 chr4:120376271 NA -0.66 -13.07 -0.46 9.57e-35 Coronary artery disease; BRCA cis rs10771431 0.597 rs3759275 chr12:9353828 A/T cg08997352 chr12:9597637 DDX12 -0.54 -10.21 -0.37 8.78e-23 Breast size; BRCA cis rs12477438 0.501 rs6753063 chr2:99801469 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.88 28.21 0.74 2.43e-114 Chronic sinus infection; BRCA cis rs10489202 0.634 rs11582396 chr1:168077636 C/T cg24449463 chr1:168025552 DCAF6 -0.47 -14.7 -0.5 2.37e-42 Schizophrenia; BRCA cis rs7098414 0.511 rs7899545 chr10:82150635 G/C cg00277334 chr10:82204260 NA -0.5 -10.7 -0.39 1.05e-24 Post bronchodilator FEV1; BRCA cis rs1801251 1.000 rs1947105 chr2:233721455 A/G cg25237894 chr2:233734115 C2orf82 0.41 11.9 0.43 1.23e-29 Coronary artery disease; BRCA cis rs79057730 0.599 rs9458 chr7:825494 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.74 -10.53 -0.38 4.89e-24 Initial pursuit acceleration; BRCA cis rs3768617 0.510 rs10797839 chr1:183077797 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.73 0.57 1.64e-57 Fuchs's corneal dystrophy; BRCA cis rs9527 0.590 rs12775302 chr10:104911356 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.05e-24 Arsenic metabolism; BRCA cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg01579765 chr21:45077557 HSF2BP -0.38 -10.1 -0.37 2.46e-22 Mean corpuscular volume; BRCA trans rs2270927 1.000 rs4546360 chr5:75577563 T/C cg13563193 chr19:33072644 PDCD5 0.84 11.5 0.41 5.9e-28 Mean corpuscular volume; BRCA cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg04546413 chr19:29218101 NA 0.49 8.47 0.32 1.63e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs12618769 0.625 rs56240302 chr2:99148970 C/T cg10123293 chr2:99228465 UNC50 0.42 8.15 0.31 1.92e-15 Bipolar disorder; BRCA trans rs2235573 0.551 rs139897 chr22:38399098 A/G cg19894588 chr14:64061835 NA 0.36 8.14 0.31 2.09e-15 Glioblastoma;Glioma; BRCA cis rs2153535 0.580 rs1414342 chr6:8462552 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.13 0.49 1.16e-39 Motion sickness; BRCA cis rs7394190 0.748 rs2306325 chr10:75506674 T/C cg07699608 chr10:75541558 CHCHD1 0.6 8.87 0.33 7.03e-18 Incident atrial fibrillation; BRCA cis rs6121246 0.559 rs6060952 chr20:30382108 T/G cg13852791 chr20:30311386 BCL2L1 0.84 17.93 0.58 1.62e-58 Mean corpuscular hemoglobin; BRCA cis rs11229555 0.645 rs11229460 chr11:58208343 T/C cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7647973 1.000 rs6785045 chr3:49435243 G/C cg07636037 chr3:49044803 WDR6 -0.73 -15.84 -0.53 6.49e-48 Menarche (age at onset); BRCA cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs7586879 1.000 rs1865687 chr2:25112885 G/A cg04586622 chr2:25135609 ADCY3 0.4 9.39 0.35 1.07e-19 Body mass index; BRCA cis rs775227 0.574 rs34286076 chr3:113269695 G/C cg18753928 chr3:113234510 CCDC52 -0.57 -9.32 -0.35 1.79e-19 Dental caries; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.6 -12.71 -0.45 3.81e-33 Lymphocyte counts; BRCA cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg20203395 chr5:56204925 C5orf35 0.64 12.56 0.45 1.65e-32 Initial pursuit acceleration; BRCA trans rs11098499 0.604 rs34278750 chr4:120571136 G/A cg25214090 chr10:38739885 LOC399744 0.52 10.95 0.4 1.08e-25 Corneal astigmatism; BRCA trans rs459571 0.959 rs2520099 chr9:136918139 T/C cg09836344 chr4:1243392 C4orf42;CTBP1 -0.74 -14.81 -0.51 7.31e-43 Platelet distribution width; BRCA cis rs1801251 0.896 rs2305141 chr2:233684402 A/G cg08000102 chr2:233561755 GIGYF2 -0.59 -12.6 -0.45 1.13e-32 Coronary artery disease; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg13047869 chr3:10149882 C3orf24 0.48 10.4 0.38 1.59e-23 Alzheimer's disease; BRCA trans rs11098499 0.657 rs10434028 chr4:120294464 T/G cg25214090 chr10:38739885 LOC399744 0.48 11.01 0.4 6.44e-26 Corneal astigmatism; BRCA cis rs7098414 0.511 rs12262228 chr10:82160425 C/T cg01528321 chr10:82214614 TSPAN14 0.69 14.59 0.5 7.96e-42 Post bronchodilator FEV1; BRCA cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg09555818 chr19:45449301 APOC2 0.47 12.52 0.44 2.6e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7618915 0.501 rs3733045 chr3:52643307 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -11.41 -0.41 1.39e-27 Bipolar disorder; BRCA cis rs3806843 0.771 rs2563334 chr5:140107065 C/G cg16179182 chr5:140090404 VTRNA1-1 0.45 10.34 0.38 2.9e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs6785206 0.803 rs2712380 chr3:128338661 A/C cg16766828 chr3:128327626 NA -0.8 -11.66 -0.42 1.34e-28 Lymphocyte percentage of white cells; BRCA cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg04450456 chr4:17643702 FAM184B -0.35 -9.62 -0.36 1.5e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10751667 0.621 rs4075990 chr11:976614 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg24642439 chr20:33292090 TP53INP2 0.73 17.05 0.56 4.99e-54 Coronary artery disease; BRCA cis rs11098499 0.863 rs7657849 chr4:120455494 T/C cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs17818399 0.708 rs13000706 chr2:46838247 C/G cg02822958 chr2:46747628 ATP6V1E2 0.43 8.81 0.33 1.18e-17 Height; BRCA cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg22974920 chr21:40686053 BRWD1 -0.41 -9.0 -0.34 2.65e-18 Cognitive function; BRCA cis rs61524473 1 rs61524473 chr15:45646283 T/C cg21132104 chr15:45694354 SPATA5L1 0.73 16.14 0.54 2.01e-49 Metabolite levels (small molecules and protein measures); BRCA cis rs3772130 0.962 rs17742508 chr3:121559895 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.75 0.39 6.71e-25 Cognitive performance; BRCA cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg13010199 chr12:38710504 ALG10B 0.57 12.56 0.44 1.79e-32 Heart rate; BRCA cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg12927641 chr6:109611667 NA -0.42 -10.89 -0.4 1.88e-25 Reticulocyte fraction of red cells; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg02951883 chr7:2050386 MAD1L1 -0.61 -15.14 -0.51 1.71e-44 Bipolar disorder and schizophrenia; BRCA cis rs701145 0.938 rs813141 chr3:154066521 T/C cg17054900 chr3:154042577 DHX36 0.66 11.41 0.41 1.46e-27 Coronary artery disease; BRCA cis rs4595586 0.566 rs11615585 chr12:39409351 C/T cg26384229 chr12:38710491 ALG10B 0.43 9.61 0.36 1.69e-20 Morning vs. evening chronotype; BRCA cis rs9462027 0.628 rs7739771 chr6:34779801 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.84 -0.3 1.96e-14 Systemic lupus erythematosus; BRCA cis rs9787249 0.915 rs58589165 chr1:40213670 A/T cg24920358 chr1:40204285 PPIE 0.33 7.81 0.3 2.3e-14 Blood protein levels; BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg22920501 chr2:26401640 FAM59B 0.64 11.46 0.41 8.99e-28 Gut microbiome composition (summer); BRCA cis rs6684514 1.000 rs59468948 chr1:156288058 A/T cg16558208 chr1:156270281 VHLL 0.36 8.28 0.31 6.96e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7560272 0.512 rs4530394 chr2:73929650 T/C cg20560298 chr2:73613845 ALMS1 0.34 8.86 0.33 7.81e-18 Schizophrenia; BRCA trans rs9325144 0.554 rs7960616 chr12:39096664 T/A cg23762105 chr12:34175262 ALG10 0.35 7.87 0.3 1.51e-14 Morning vs. evening chronotype; BRCA cis rs7072216 0.770 rs1737 chr10:100176366 T/C cg26618903 chr10:100175079 PYROXD2 -0.27 -8.17 -0.31 1.66e-15 Metabolite levels; BRCA cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg04317338 chr11:64019027 PLCB3 0.52 7.9 0.3 1.19e-14 Mean platelet volume; BRCA cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.77 0.36 4.3e-21 Bipolar disorder; BRCA cis rs6450176 0.909 rs6884760 chr5:53293077 T/A ch.5.1024479R chr5:53302184 ARL15 -0.59 -13.85 -0.48 2.33e-38 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg20908204 chr19:46285434 DMPK -0.29 -8.56 -0.32 8.25e-17 Coronary artery disease; BRCA cis rs11051970 0.879 rs2171373 chr12:32575777 C/T cg24626660 chr12:32551988 NA 0.29 8.16 0.31 1.75e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9287719 0.649 rs10184776 chr2:10726446 C/T cg00105475 chr2:10696890 NA 0.41 9.2 0.34 4.95e-19 Prostate cancer; BRCA cis rs9649465 0.967 rs1005567 chr7:123305836 A/T cg04330084 chr7:123175371 IQUB 0.3 8.38 0.31 3.32e-16 Migraine; BRCA cis rs7772486 0.790 rs9403750 chr6:146167762 G/A cg13319975 chr6:146136371 FBXO30 -0.34 -7.95 -0.3 8.48e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7659604 0.539 rs3217753 chr4:122746325 A/G cg06713675 chr4:122721982 EXOSC9 -0.53 -12.57 -0.45 1.56e-32 Type 2 diabetes; BRCA cis rs4363385 0.747 rs4319267 chr1:152972699 T/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.02 -0.34 2.12e-18 Inflammatory skin disease; BRCA cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg12573674 chr2:1569213 NA -0.64 -14.48 -0.5 2.8e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs11955398 0.563 rs4700385 chr5:60032599 G/A cg02684056 chr5:59996105 DEPDC1B -0.41 -9.5 -0.35 4.27e-20 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.967 rs7321596 chr13:44472255 G/A cg17145862 chr1:211918768 LPGAT1 0.7 18.22 0.58 4.67e-60 Leprosy; BRCA cis rs10504229 0.815 rs17805008 chr8:58160185 G/T cg22535103 chr8:58192502 C8orf71 -0.5 -8.86 -0.33 7.85e-18 Developmental language disorder (linguistic errors); BRCA cis rs9815354 0.761 rs73083329 chr3:41927151 C/T cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs9309473 1.000 rs10190219 chr2:73658331 C/T cg20560298 chr2:73613845 ALMS1 -0.46 -11.41 -0.41 1.38e-27 Metabolite levels; BRCA cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 0.530 rs12915184 chr15:76965922 G/A cg23625390 chr15:77176239 SCAPER -0.53 -11.33 -0.41 3.14e-27 Blood metabolite levels; BRCA cis rs6005807 0.719 rs134547 chr22:28801009 A/G cg12565055 chr22:29076175 TTC28 0.46 9.03 0.34 2.03e-18 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg14993813 chr1:46806288 NSUN4 -0.5 -9.49 -0.35 4.48e-20 Menopause (age at onset); BRCA cis rs7100689 0.556 rs946893 chr10:82023524 A/G cg01528321 chr10:82214614 TSPAN14 0.74 16.88 0.56 4.06e-53 Post bronchodilator FEV1; BRCA cis rs600806 0.778 rs4970731 chr1:109995459 T/C cg20591472 chr1:110008990 SYPL2 0.31 7.86 0.3 1.69e-14 Intelligence (multi-trait analysis); BRCA trans rs1941687 0.509 rs7238029 chr18:31317755 A/G cg27147174 chr7:100797783 AP1S1 -0.48 -9.13 -0.34 8.55e-19 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs2635047 0.967 rs7242978 chr18:44633424 G/T cg19077165 chr18:44547161 KATNAL2 0.41 8.73 0.33 2.14e-17 Educational attainment; BRCA cis rs12479064 0.604 rs11893359 chr2:99954608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.44 -8.53 -0.32 1.06e-16 Chronic sinus infection; BRCA cis rs7149337 0.805 rs7146561 chr14:51608889 C/G cg23942311 chr14:51606299 NA 0.45 13.31 0.47 7.73e-36 Cancer; BRCA cis rs34172651 0.837 rs1978451 chr16:24818286 C/G cg00152838 chr16:24741724 TNRC6A -0.35 -7.96 -0.3 7.96e-15 Intelligence (multi-trait analysis); BRCA cis rs1185460 1.000 rs1185460 chr11:118943433 C/T cg23280166 chr11:118938394 VPS11 -0.4 -9.52 -0.35 3.36e-20 Coronary artery disease; BRCA cis rs4713118 0.513 rs149955 chr6:28036225 G/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.9 0.3 1.26e-14 Parkinson's disease; BRCA trans rs7618501 1.000 rs35261599 chr3:49773236 G/A cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.5 -0.38 6.61e-24 Intelligence (multi-trait analysis); BRCA cis rs514406 0.644 rs7530078 chr1:53204861 G/T cg25767906 chr1:53392781 SCP2 0.34 7.88 0.3 1.42e-14 Monocyte count; BRCA cis rs7267979 1.000 rs4815406 chr20:25341316 C/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.28 -0.34 2.52e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1011018 0.628 rs7793114 chr7:139450785 A/G cg03224163 chr7:139420300 HIPK2 -0.52 -8.04 -0.3 4.25e-15 Systolic blood pressure; BRCA cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg15506890 chr2:3487001 NA -0.58 -13.14 -0.46 4.26e-35 Neurofibrillary tangles; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg00166722 chr3:10149974 C3orf24 0.56 11.16 0.4 1.5e-26 Alzheimer's disease; BRCA cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg24130564 chr14:104152367 KLC1 -0.39 -8.93 -0.33 4.67e-18 Intelligence (multi-trait analysis); BRCA cis rs4880487 0.888 rs35341304 chr10:1252526 T/C cg03183215 chr10:1252341 ADARB2 -0.37 -8.4 -0.32 2.82e-16 Migraine; BRCA cis rs514406 0.893 rs512723 chr1:53343880 C/T cg16325326 chr1:53192061 ZYG11B -0.71 -16.3 -0.54 3.4e-50 Monocyte count; BRCA cis rs7927592 0.913 rs7116994 chr11:68254627 C/T cg20283391 chr11:68216788 NA -0.45 -9.32 -0.35 1.81e-19 Total body bone mineral density; BRCA cis rs875971 0.545 rs67688847 chr7:65626051 G/A cg11764359 chr7:65958608 NA 0.65 11.9 0.43 1.21e-29 Aortic root size; BRCA cis rs2625529 0.824 rs4777471 chr15:72207804 A/G cg16672083 chr15:72433130 SENP8 -0.83 -17.22 -0.56 7.38e-55 Red blood cell count; BRCA cis rs765787 0.530 rs12442533 chr15:45529631 G/C cg15395560 chr15:45543142 SLC28A2 -0.29 -7.93 -0.3 1.01e-14 Uric acid levels; BRCA cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg14289826 chr9:140003911 NA -0.54 -15.06 -0.51 4.18e-44 Cerebrospinal fluid biomarker levels; BRCA cis rs12540874 0.500 rs12719030 chr7:50485073 T/C cg18232548 chr7:50535776 DDC -0.48 -12.14 -0.43 1.12e-30 Systemic sclerosis; BRCA cis rs9818758 0.607 rs73082362 chr3:49113729 C/T cg01304814 chr3:48885189 PRKAR2A 0.77 7.9 0.3 1.18e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg03354898 chr7:1950403 MAD1L1 -0.6 -14.43 -0.5 4.83e-41 Bipolar disorder and schizophrenia; BRCA cis rs778371 0.624 rs6733495 chr2:233616709 A/G cg08000102 chr2:233561755 GIGYF2 0.84 20.64 0.63 6.87e-73 Schizophrenia; BRCA cis rs1008375 0.932 rs6449317 chr4:17631253 T/C cg16339924 chr4:17578868 LAP3 0.71 17.02 0.56 7.17e-54 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs208520 0.690 rs2144081 chr6:66824972 G/A cg07460842 chr6:66804631 NA -1.02 -20.03 -0.62 1.26e-69 Exhaled nitric oxide output; BRCA cis rs10504229 1.000 rs56350499 chr8:58178139 C/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7582180 0.715 rs764828 chr2:100908634 A/C cg14675211 chr2:100938903 LONRF2 0.45 9.77 0.36 4.13e-21 Intelligence (multi-trait analysis); BRCA cis rs1451375 0.527 rs6950777 chr7:50597056 G/A cg18232548 chr7:50535776 DDC 0.43 9.68 0.36 8.73e-21 Malaria; BRCA cis rs2985684 1.000 rs2147712 chr14:50091684 G/A cg04989706 chr14:50066350 PPIL5 -0.48 -9.2 -0.34 5.18e-19 Carotid intima media thickness; BRCA cis rs11105298 0.891 rs11105313 chr12:89923376 A/T cg08166232 chr12:89918718 WDR51B;GALNT4 0.55 9.36 0.35 1.34e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs6479891 1.000 rs61855465 chr10:64956607 A/T cg14819942 chr15:35414228 NA 0.35 8.52 0.32 1.13e-16 Arthritis (juvenile idiopathic); BRCA cis rs2251381 0.722 rs2776252 chr21:30531705 G/A cg08807101 chr21:30365312 RNF160 0.62 13.57 0.47 4.6e-37 Selective IgA deficiency; BRCA cis rs8114671 0.869 rs6060199 chr20:33654773 A/G cg07148914 chr20:33460835 GGT7 -0.43 -9.17 -0.34 6.56e-19 Height; BRCA cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg16405210 chr4:1374714 KIAA1530 0.84 17.4 0.57 8.09e-56 Longevity; BRCA cis rs7833986 1.000 rs72654002 chr8:57095939 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.27 0.31 8.08e-16 Height; BRCA cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -12.13 -0.43 1.22e-30 Chronic sinus infection; BRCA cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03352830 chr11:487213 PTDSS2 -0.8 -11.94 -0.43 8.59e-30 Body mass index; BRCA cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg00677455 chr12:58241039 CTDSP2 0.63 14.19 0.49 6.18e-40 Multiple sclerosis; BRCA cis rs7560272 0.501 rs11891140 chr2:73944084 A/G cg20560298 chr2:73613845 ALMS1 0.33 8.45 0.32 1.96e-16 Schizophrenia; BRCA cis rs2839627 0.598 rs2246573 chr21:44253016 C/T cg03543861 chr21:44258195 NA -0.42 -8.68 -0.32 3.28e-17 Information processing speed; BRCA cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg00745463 chr17:30367425 LRRC37B -0.61 -9.54 -0.35 2.91e-20 Hip circumference adjusted for BMI; BRCA cis rs4853036 0.723 rs3732268 chr2:70046262 G/A cg02498382 chr2:70120550 SNRNP27 -0.53 -8.56 -0.32 8.42e-17 Colorectal or endometrial cancer; BRCA cis rs7552404 0.924 rs1146581 chr1:76213024 T/G cg03433033 chr1:76189801 ACADM 0.74 19.0 0.6 4e-64 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs2562456 0.837 rs62110205 chr19:21760071 A/G cg25042112 chr7:64838748 ZNF92 -0.44 -8.04 -0.3 4.31e-15 Pain; BRCA cis rs3761847 0.651 rs1323472 chr9:123826335 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.41 8.38 0.31 3.28e-16 Rheumatoid arthritis; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg22920501 chr2:26401640 FAM59B 0.72 13.34 0.47 5.7e-36 Gut microbiome composition (summer); BRCA cis rs10751667 0.643 rs7396951 chr11:927355 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.16e-47 Alzheimer's disease (late onset); BRCA cis rs897984 0.568 rs4889653 chr16:30895713 C/T cg02466173 chr16:30829666 NA 0.43 8.66 0.32 3.83e-17 Dementia with Lewy bodies; BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg21782813 chr7:2030301 MAD1L1 0.33 8.79 0.33 1.34e-17 Bipolar disorder and schizophrenia; BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs9814567 1.000 rs9289475 chr3:134236459 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.63 -0.61 1.65e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9633740 1.000 rs7900536 chr10:82253701 G/T cg00277334 chr10:82204260 NA -0.47 -7.95 -0.3 8.74e-15 Post bronchodilator FEV1; BRCA cis rs4727027 0.704 rs1123992 chr7:148907201 C/G cg23583168 chr7:148888333 NA -0.82 -19.5 -0.61 8.67e-67 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2279817 0.735 rs11580813 chr1:17981913 C/T cg21791023 chr1:18019539 ARHGEF10L 0.5 11.81 0.42 3.05e-29 Neuroticism; BRCA cis rs72781680 0.898 rs17762651 chr2:24115922 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.06 0.34 1.57e-18 Lymphocyte counts; BRCA cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.51 0.71 1.6e-99 Chronic sinus infection; BRCA cis rs2153535 0.580 rs1119689 chr6:8460754 C/G cg21535247 chr6:8435926 SLC35B3 0.4 8.98 0.33 3.04e-18 Motion sickness; BRCA cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.89 29.81 0.76 4.96e-123 Chronic sinus infection; BRCA cis rs4975616 0.869 rs380286 chr5:1320247 G/A cg06550200 chr5:1325588 CLPTM1L -0.64 -13.63 -0.47 2.59e-37 Lung cancer; BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg22920501 chr2:26401640 FAM59B -0.81 -13.09 -0.46 7.18e-35 Gut microbiome composition (summer); BRCA cis rs1997103 0.954 rs1917769 chr7:55392325 T/A cg17469321 chr7:55412551 NA 0.52 9.82 0.36 2.79e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs801193 0.591 rs4506088 chr7:66135457 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.81 -0.3 2.36e-14 Aortic root size; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg27170947 chr2:26402098 FAM59B 0.97 16.91 0.56 2.72e-53 Gut microbiome composition (summer); BRCA cis rs2832191 0.755 rs2832192 chr21:30491173 G/T cg24692254 chr21:30365293 RNF160 -0.64 -16.28 -0.54 4.16e-50 Dental caries; BRCA cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs11031096 0.727 rs2268168 chr11:4142069 C/T cg18678763 chr11:4115507 RRM1 -0.37 -8.22 -0.31 1.18e-15 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6005807 0.719 rs9625520 chr22:29037864 C/A cg12565055 chr22:29076175 TTC28 0.49 9.23 0.34 3.82e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs312273 0.806 rs55638600 chr12:41338491 G/A cg17827154 chr12:41323612 CNTN1 -0.43 -11.13 -0.4 1.97e-26 Bipolar disorder; BRCA cis rs7633857 0.536 rs2889391 chr3:160696186 A/G cg03342759 chr3:160939853 NMD3 -0.49 -10.01 -0.37 5.33e-22 Educational attainment (years of education); BRCA cis rs919433 0.963 rs12617117 chr2:198155170 T/A cg10820045 chr2:198174542 NA -0.39 -7.97 -0.3 7.24e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6912958 0.559 rs242287 chr6:88071825 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.54 10.92 0.4 1.45e-25 Monocyte percentage of white cells; BRCA cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg11833968 chr6:79620685 NA 0.42 9.27 0.34 2.74e-19 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.520 rs7803208 chr7:1162084 C/T cg23978390 chr7:1156363 C7orf50 0.43 9.81 0.36 3.02e-21 Bronchopulmonary dysplasia; BRCA cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg03474202 chr17:45855739 NA -0.47 -12.78 -0.45 1.78e-33 IgG glycosylation; BRCA cis rs4594175 0.926 rs10135534 chr14:51617970 C/A cg23942311 chr14:51606299 NA 0.33 8.41 0.32 2.69e-16 Cancer; BRCA cis rs1505368 0.781 rs4673664 chr2:213277649 T/C cg20637307 chr2:213403960 ERBB4 0.38 9.26 0.34 3.08e-19 Symmetrical dimethylarginine levels; BRCA cis rs1878931 0.520 rs2015640 chr16:3465018 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -9.49 -0.35 4.56e-20 Body mass index (adult); BRCA cis rs801193 0.660 rs974239 chr7:66213491 G/A cg18876405 chr7:65276391 NA 0.53 12.16 0.43 9.33e-31 Aortic root size; BRCA cis rs2294693 0.947 rs736795 chr6:40998141 G/A cg14418226 chr6:40996092 UNC5CL 0.46 8.36 0.31 3.78e-16 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg11764359 chr7:65958608 NA -0.62 -13.48 -0.47 1.19e-36 Aortic root size; BRCA cis rs28595532 0.920 rs17258830 chr4:119725543 A/T cg21605333 chr4:119757512 SEC24D -1.26 -13.57 -0.47 4.91e-37 Cannabis dependence symptom count; BRCA cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs6598955 0.543 rs112752634 chr1:26534217 G/A cg04990556 chr1:26633338 UBXN11 0.7 11.69 0.42 9.64e-29 Obesity-related traits; BRCA cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg12751644 chr20:60527061 NA 0.36 7.96 0.3 7.63e-15 Obesity-related traits; BRCA cis rs6582630 0.519 rs7305545 chr12:38349223 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.49 0.38 7.33e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.830 rs10005173 chr4:98816062 T/C cg05340658 chr4:99064831 C4orf37 0.62 14.78 0.5 9.83e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.915 rs1473553 chr12:122985057 G/T cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.11 -0.37 2.19e-22 Body mass index; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg07092213 chr7:1199455 ZFAND2A -0.42 -8.27 -0.31 8.04e-16 Longevity;Endometriosis; BRCA cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg06108461 chr20:60628389 TAF4 -0.79 -16.99 -0.56 1.13e-53 Body mass index; BRCA cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg18230493 chr5:56204884 C5orf35 -0.74 -14.72 -0.5 1.98e-42 Initial pursuit acceleration; BRCA cis rs7662987 0.540 rs2851278 chr4:100021253 G/C cg13256891 chr4:100009986 ADH5 0.55 10.15 0.37 1.58e-22 Smoking initiation; BRCA cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg01819863 chr10:32635814 EPC1 1.16 20.46 0.63 6.39e-72 Sexual dysfunction (female); BRCA cis rs701145 0.585 rs1609205 chr3:153793923 G/A cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs4908768 0.501 rs2016084 chr1:8613418 C/A cg20416874 chr1:8611966 RERE -0.28 -8.17 -0.31 1.7e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs7772486 0.738 rs75288066 chr6:146319386 C/A cg23711669 chr6:146136114 FBXO30 0.72 16.15 0.54 1.91e-49 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.754 rs1980026 chr4:120251643 C/A cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA cis rs2624839 0.602 rs2526390 chr3:50192760 C/T cg24110177 chr3:50126178 RBM5 -0.46 -11.53 -0.42 4.37e-28 Intelligence (multi-trait analysis); BRCA cis rs736801 0.780 rs12521868 chr5:131784393 A/C cg07395648 chr5:131743802 NA 0.38 8.64 0.32 4.45e-17 Breast cancer;Mosquito bite size; BRCA cis rs7666738 0.830 rs28516388 chr4:98987449 A/G cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.686 rs857880 chr6:145971115 T/C cg23711669 chr6:146136114 FBXO30 -0.77 -18.38 -0.59 6.56e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs9291683 0.530 rs882223 chr4:9981625 A/C cg11266682 chr4:10021025 SLC2A9 0.41 10.86 0.39 2.57e-25 Bone mineral density; BRCA cis rs9291683 0.595 rs35250962 chr4:10048271 C/T cg11266682 chr4:10021025 SLC2A9 0.48 12.69 0.45 4.38e-33 Bone mineral density; BRCA trans rs853679 0.546 rs13214023 chr6:28332141 A/G cg01620082 chr3:125678407 NA 0.87 10.82 0.39 3.45e-25 Depression; BRCA cis rs4845875 0.600 rs10779765 chr1:11838011 T/C cg24844545 chr1:11908347 NPPA 0.37 8.68 0.32 3.35e-17 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6952808 0.529 rs73038442 chr7:2139457 C/T cg03354898 chr7:1950403 MAD1L1 -0.47 -9.54 -0.35 2.86e-20 Bipolar disorder and schizophrenia; BRCA cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg08704250 chr15:31115839 NA -0.35 -8.82 -0.33 1.09e-17 Huntington's disease progression; BRCA cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs6460942 0.915 rs1595802 chr7:12439672 C/T cg20607287 chr7:12443886 VWDE -0.54 -8.28 -0.31 7.46e-16 Coronary artery disease; BRCA cis rs1451375 0.583 rs3807555 chr7:50610569 A/G cg18232548 chr7:50535776 DDC 0.42 9.0 0.34 2.63e-18 Malaria; BRCA trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs6449329 chr4:17703677 T/C cg02297831 chr4:17616191 MED28 0.36 8.38 0.31 3.31e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2576037 0.526 rs2156050 chr18:44455873 A/G cg19077165 chr18:44547161 KATNAL2 -0.53 -11.48 -0.41 7.3e-28 Personality dimensions; BRCA cis rs8017423 0.934 rs11159952 chr14:90684874 T/C cg14092571 chr14:90743983 NA -0.34 -8.12 -0.31 2.36e-15 Mortality in heart failure; BRCA cis rs6782228 0.606 rs2001703 chr3:128383097 A/G cg16766828 chr3:128327626 NA -0.44 -9.8 -0.36 3.11e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7582180 0.629 rs11693471 chr2:100948062 G/A cg14675211 chr2:100938903 LONRF2 0.53 12.03 0.43 3.34e-30 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.818 rs2152994 chr1:152991060 C/T cg25856811 chr1:152973957 SPRR3 0.3 8.27 0.31 7.58e-16 Inflammatory skin disease; BRCA cis rs6435161 0.919 rs2162495 chr2:203578008 A/G cg18429434 chr2:203499731 FAM117B -0.45 -8.87 -0.33 7e-18 Total cholesterol levels; BRCA cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg24110177 chr3:50126178 RBM5 0.36 9.75 0.36 4.79e-21 Intelligence (multi-trait analysis); BRCA cis rs2239547 0.522 rs2336162 chr3:52951519 C/T cg11645453 chr3:52864694 ITIH4 -0.43 -10.9 -0.4 1.78e-25 Schizophrenia; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.96 -0.3 8.15e-15 Total body bone mineral density; BRCA cis rs9486715 0.867 rs9384585 chr6:96875664 C/T cg06623918 chr6:96969491 KIAA0776 0.9 25.45 0.71 3.19e-99 Headache; BRCA cis rs6754311 0.861 rs12475139 chr2:136786651 A/T cg07169764 chr2:136633963 MCM6 0.65 13.43 0.47 2.02e-36 Mosquito bite size; BRCA cis rs7267979 1.000 rs2500404 chr20:25359758 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7945705 0.747 rs1980429 chr11:9010474 C/A cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -13.52 -0.47 8.51e-37 Hemoglobin concentration; BRCA cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg21770322 chr7:97807741 LMTK2 0.41 10.8 0.39 4.32e-25 Prostate cancer (SNP x SNP interaction); BRCA trans rs2204008 0.748 rs11514352 chr12:38246954 C/T cg06521331 chr12:34319734 NA -0.53 -9.51 -0.35 3.7e-20 Bladder cancer; BRCA cis rs1008375 1.000 rs10939750 chr4:17692422 C/G cg16339924 chr4:17578868 LAP3 0.57 14.01 0.48 4.42e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2070488 0.965 rs6796845 chr3:38567771 C/A cg24069376 chr3:38537580 EXOG -0.42 -12.05 -0.43 2.72e-30 Electrocardiographic conduction measures; BRCA cis rs3096299 0.685 rs12446145 chr16:89542695 C/T cg02187348 chr16:89574699 SPG7 0.5 11.98 0.43 5.78e-30 Multiple myeloma (IgH translocation); BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs2836974 0.897 rs2836933 chr21:40564202 C/G cg11890956 chr21:40555474 PSMG1 1.05 29.89 0.76 1.68e-123 Cognitive function; BRCA trans rs11098499 0.697 rs11941899 chr4:120382758 C/A cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs9814567 1.000 rs6782563 chr3:134295959 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.89 0.33 6.17e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9381107 0.932 rs10484246 chr6:9451197 T/A cg14735645 chr6:9486422 NA -0.45 -7.92 -0.3 1.09e-14 Nonsyndromic cleft lip with cleft palate; BRCA cis rs8177253 0.666 rs8177197 chr3:133469530 G/A cg16414030 chr3:133502952 NA -0.42 -9.13 -0.34 8.66e-19 Iron status biomarkers; BRCA cis rs12474201 0.928 rs34186074 chr2:46965010 T/C cg06386533 chr2:46925753 SOCS5 0.9 19.94 0.62 3.63e-69 Height; BRCA cis rs9527 0.590 rs7092029 chr10:104823909 A/T cg04362960 chr10:104952993 NT5C2 0.43 9.77 0.36 4.15e-21 Arsenic metabolism; BRCA cis rs4481887 0.927 rs4581306 chr1:248476158 C/A cg13385794 chr1:248469461 NA 0.27 7.85 0.3 1.75e-14 Common traits (Other); BRCA cis rs4938330 0.629 rs12269901 chr11:116973929 C/G cg01368799 chr11:117014884 PAFAH1B2 -0.41 -7.89 -0.3 1.33e-14 Blood protein levels; BRCA cis rs698833 0.892 rs1085483 chr2:44616047 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.25 0.38 6.05e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9649213 0.593 rs6465666 chr7:97937258 C/T cg24562669 chr7:97807699 LMTK2 -0.45 -11.81 -0.42 2.92e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.56e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs8114671 0.869 rs1544047 chr20:33670753 T/C cg24642439 chr20:33292090 TP53INP2 -0.44 -8.82 -0.33 1.12e-17 Height; BRCA cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.78e-39 Alzheimer's disease; BRCA cis rs9462846 0.959 rs57514728 chr6:42860748 C/T cg02353165 chr6:42928485 GNMT 0.49 8.64 0.32 4.47e-17 Blood protein levels; BRCA cis rs586533 0.793 rs681361 chr11:99501905 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9649213 0.593 rs36017146 chr7:97974617 C/T cg24562669 chr7:97807699 LMTK2 0.46 12.19 0.43 6.71e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.747 rs4240868 chr1:152981599 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs6866344 0.697 rs61247551 chr5:178133503 G/A cg03877680 chr5:178157825 ZNF354A 0.79 14.65 0.5 4.19e-42 Neutrophil percentage of white cells; BRCA cis rs10791323 0.720 rs2851117 chr11:133705905 A/G cg15485101 chr11:133734466 NA -0.37 -9.4 -0.35 9.25e-20 Childhood ear infection; BRCA cis rs769267 0.930 rs1054284 chr19:19616953 T/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.16 0.31 1.81e-15 Tonsillectomy; BRCA cis rs8072100 0.713 rs2136750 chr17:45456100 A/G cg25173405 chr17:45401733 C17orf57 -0.53 -10.82 -0.39 3.73e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg12432903 chr7:1882776 MAD1L1 0.44 8.02 0.3 5.17e-15 Bipolar disorder; BRCA cis rs734999 0.967 rs10797434 chr1:2511280 C/T cg20673091 chr1:2541236 MMEL1 0.33 8.53 0.32 1.08e-16 Ulcerative colitis; BRCA cis rs36051895 0.695 rs60221565 chr9:5029077 T/G cg02405213 chr9:5042618 JAK2 -0.51 -9.12 -0.34 9.7e-19 Pediatric autoimmune diseases; BRCA cis rs28830936 0.510 rs12440605 chr15:42102285 A/G cg17847044 chr15:42102381 MAPKBP1 0.51 19.84 0.62 1.21e-68 Diastolic blood pressure; BRCA cis rs30380 0.632 rs149189 chr5:96137804 A/G cg16492584 chr5:96139282 ERAP1 -0.47 -11.09 -0.4 2.87e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs752010 0.756 rs6600380 chr1:42054814 C/T cg06885757 chr1:42089581 HIVEP3 -0.22 -8.04 -0.3 4.42e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9814567 1.000 rs1534026 chr3:134284767 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.91 -0.33 5.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7927771 0.524 rs7943464 chr11:47886639 T/A cg20307385 chr11:47447363 PSMC3 0.42 9.47 0.35 5.32e-20 Subjective well-being; BRCA cis rs9527 0.545 rs7095304 chr10:104954795 G/A cg04362960 chr10:104952993 NT5C2 0.43 9.75 0.36 4.83e-21 Arsenic metabolism; BRCA cis rs858239 0.601 rs6948469 chr7:23174766 G/T cg23682824 chr7:23144976 KLHL7 0.42 10.98 0.4 8.11e-26 Cerebrospinal fluid biomarker levels; BRCA trans rs853679 0.599 rs149990 chr6:27998258 G/A cg01620082 chr3:125678407 NA -0.53 -8.02 -0.3 5e-15 Depression; BRCA cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg11279151 chr3:101281821 RG9MTD1 -0.5 -9.71 -0.36 7.11e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.500 rs6488221 chr12:34525671 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.54 0.47 6.37e-37 Morning vs. evening chronotype; BRCA cis rs7829975 0.623 rs10087493 chr8:8373557 A/G cg14343924 chr8:8086146 FLJ10661 -0.41 -8.53 -0.32 1.09e-16 Mood instability; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg03188948 chr7:1209495 NA 0.88 13.83 0.48 3.04e-38 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs7647973 0.626 rs1463728 chr3:49647404 T/A cg21659725 chr3:3221576 CRBN -0.47 -8.41 -0.32 2.76e-16 Menarche (age at onset); BRCA cis rs6435862 0.593 rs34732883 chr2:215674371 C/T cg04530015 chr2:215796436 ABCA12 0.39 8.57 0.32 7.69e-17 Neuroblastoma (high-risk); BRCA cis rs35110281 0.506 rs13051661 chr21:45111518 A/T cg04455712 chr21:45112962 RRP1B 0.45 11.58 0.42 2.67e-28 Mean corpuscular volume; BRCA cis rs7267979 0.966 rs8123949 chr20:25388133 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.64 -0.32 4.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4478858 0.684 rs4949202 chr1:31736800 T/C cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7582180 0.629 rs11686649 chr2:100946701 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA cis rs243505 0.762 rs734004 chr7:148505460 C/G cg09806900 chr7:148480153 CUL1 0.5 10.52 0.38 5.46e-24 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4819052 0.765 rs2838827 chr21:46656146 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.48 9.25 0.34 3.19e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg22920501 chr2:26401640 FAM59B -0.66 -11.44 -0.41 1.1e-27 Gut microbiome composition (summer); BRCA cis rs10911232 0.507 rs10911222 chr1:183047363 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 16.95 0.56 1.78e-53 Hypertriglyceridemia; BRCA trans rs853679 0.546 rs36092177 chr6:28357807 C/T cg01620082 chr3:125678407 NA -0.97 -11.01 -0.4 6.21e-26 Depression; BRCA trans rs9951602 0.512 rs4799244 chr18:76649763 T/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.04 0.58 4.16e-59 Obesity-related traits; BRCA cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg11645453 chr3:52864694 ITIH4 0.42 9.99 0.37 6.14e-22 Bipolar disorder; BRCA cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg12011299 chr4:100065546 ADH4 0.48 10.88 0.4 2.02e-25 Smoking initiation; BRCA trans rs6479891 1.000 rs11818194 chr10:65180452 G/A cg14819942 chr15:35414228 NA 0.35 8.6 0.32 6.09e-17 Arthritis (juvenile idiopathic); BRCA cis rs4481887 0.893 rs10788774 chr1:248471712 T/C cg13385794 chr1:248469461 NA 0.28 8.02 0.3 5.16e-15 Common traits (Other); BRCA cis rs826838 0.967 rs980572 chr12:39127673 A/C cg13010199 chr12:38710504 ALG10B 0.44 10.46 0.38 9.29e-24 Heart rate; BRCA cis rs4819052 0.808 rs2246697 chr21:46689999 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4588572 0.644 rs6873144 chr5:77741784 C/T cg11547950 chr5:77652471 NA -0.42 -8.04 -0.3 4.5e-15 Triglycerides; BRCA cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg13271783 chr10:134563150 INPP5A -0.49 -9.76 -0.36 4.4e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02018176 chr4:1364513 KIAA1530 0.39 8.18 0.31 1.57e-15 Longevity; BRCA cis rs6558530 0.666 rs6558526 chr8:1702572 A/G cg19131313 chr8:1704013 NA -0.39 -7.97 -0.3 7.25e-15 Systolic blood pressure; BRCA cis rs2576037 0.583 rs8086286 chr18:44467515 A/G cg19077165 chr18:44547161 KATNAL2 0.57 12.84 0.45 1.02e-33 Personality dimensions; BRCA cis rs7312933 0.576 rs11181364 chr12:42567800 C/T cg17420585 chr12:42539391 GXYLT1 -0.38 -8.01 -0.3 5.63e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7772486 0.875 rs9403764 chr6:146360582 G/A cg05347473 chr6:146136440 FBXO30 0.4 8.02 0.3 5.03e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg21573476 chr21:45109991 RRP1B -0.36 -9.65 -0.36 1.21e-20 Mean corpuscular volume; BRCA cis rs17685 0.712 rs2158867 chr7:75815141 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.3 -0.31 6.42e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7851660 0.527 rs7870540 chr9:100573925 T/C cg13688889 chr9:100608707 NA -0.51 -11.54 -0.42 4.24e-28 Strep throat; BRCA cis rs7631605 0.905 rs11129752 chr3:37257793 A/G cg15934958 chr3:37212084 LRRFIP2 -0.5 -10.52 -0.38 5.7e-24 Cerebrospinal P-tau181p levels; BRCA cis rs72772090 0.539 rs11750934 chr5:96118487 A/C cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs5771242 0.769 rs4838865 chr22:50664612 A/G cg16473166 chr22:50639996 SELO 0.64 10.95 0.4 1.1e-25 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); BRCA cis rs113835537 0.529 rs7950407 chr11:66258006 A/G cg24851651 chr11:66362959 CCS 0.43 8.24 0.31 9.91e-16 Airway imaging phenotypes; BRCA trans rs7613875 0.641 rs6446194 chr3:50067298 T/A cg21659725 chr3:3221576 CRBN -0.35 -8.41 -0.32 2.69e-16 Body mass index; BRCA cis rs7829975 0.742 rs12547493 chr8:8661534 C/T cg06636001 chr8:8085503 FLJ10661 -0.59 -12.87 -0.45 7.5e-34 Mood instability; BRCA cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 14.09 0.49 1.8e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7267979 1.000 rs4815407 chr20:25341478 G/C cg08601574 chr20:25228251 PYGB -0.35 -8.57 -0.32 7.91e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9837602 1.000 rs6802422 chr3:99778655 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -11.0 -0.4 6.8e-26 Breast cancer; BRCA cis rs67460515 0.892 rs73026976 chr3:160964271 G/A cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Parkinson's disease; BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.56 10.07 0.37 3.2e-22 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs35615763 chr2:26468778 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs7914558 0.966 rs4532960 chr10:104667406 C/T cg04362960 chr10:104952993 NT5C2 0.43 10.36 0.38 2.42e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs3857536 0.740 rs7751095 chr6:66891318 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs2762353 0.845 rs1937130 chr6:25787554 T/A cg03264133 chr6:25882463 NA 0.49 10.93 0.4 1.34e-25 Blood metabolite levels; BRCA cis rs473651 0.935 rs508483 chr2:239339709 T/C cg18131467 chr2:239335373 ASB1 0.93 32.86 0.79 2.09e-139 Multiple system atrophy; BRCA cis rs78707713 0.560 rs17569412 chr10:71237536 C/A cg12610070 chr10:71211762 TSPAN15 -0.33 -10.03 -0.37 4.25e-22 Venous thromboembolism; BRCA cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg17971929 chr21:40555470 PSMG1 0.79 18.41 0.59 4.77e-61 Cognitive function; BRCA cis rs7267979 1.000 rs2258769 chr20:25276680 G/C cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8072100 0.713 rs11651643 chr17:45483229 A/G cg25173405 chr17:45401733 C17orf57 -0.51 -10.73 -0.39 8.42e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs490234 0.932 rs474489 chr9:128317881 C/G cg14078157 chr9:128172775 NA 0.38 9.13 0.34 8.65e-19 Mean arterial pressure; BRCA cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs6750047 0.585 rs336033 chr2:38263808 A/G cg07380506 chr2:38303506 CYP1B1 -0.47 -10.12 -0.37 2e-22 Cutaneous malignant melanoma;Melanoma; BRCA cis rs1707322 0.721 rs10890344 chr1:46166090 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7903847 0.642 rs11189192 chr10:99149403 G/A cg20016023 chr10:99160130 RRP12 -0.26 -8.55 -0.32 9.13e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs875971 0.862 rs6947339 chr7:65888470 T/C cg18876405 chr7:65276391 NA 0.51 11.2 0.4 1.08e-26 Aortic root size; BRCA cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg08045932 chr20:61659980 NA -0.49 -10.71 -0.39 9.72e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs11758351 0.929 rs75475698 chr6:26190609 C/G cg01420254 chr6:26195488 NA 0.58 9.03 0.34 2.08e-18 Gout;Renal underexcretion gout; BRCA cis rs28374715 0.662 rs28587487 chr15:41495460 C/T cg18705301 chr15:41695430 NDUFAF1 -0.87 -18.15 -0.58 1.07e-59 Ulcerative colitis; BRCA cis rs4481887 0.927 rs4292985 chr1:248473692 T/A cg00666640 chr1:248458726 OR2T12 0.3 8.39 0.32 3.12e-16 Common traits (Other); BRCA trans rs9325144 0.647 rs1386018 chr12:39104360 C/T cg23762105 chr12:34175262 ALG10 0.35 7.86 0.3 1.66e-14 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs208520 1.000 rs208535 chr6:66962286 G/A cg07460842 chr6:66804631 NA -0.86 -14.32 -0.49 1.47e-40 Exhaled nitric oxide output; BRCA cis rs61776719 0.875 rs10890238 chr1:38445654 A/T cg12481786 chr1:38455876 SF3A3 -0.36 -8.53 -0.32 1.1e-16 Coronary artery disease; BRCA cis rs7666738 0.830 rs62318472 chr4:98926030 G/A cg05340658 chr4:99064831 C4orf37 0.65 16.04 0.54 6.49e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg04944784 chr2:26401820 FAM59B 0.68 11.43 0.41 1.2100000000000001e-27 Gut microbiome composition (summer); BRCA cis rs116979167 0.514 rs1706915 chr7:105196437 A/G cg19920283 chr7:105172520 RINT1 0.44 8.95 0.33 3.92e-18 Bipolar disorder (body mass index interaction); BRCA cis rs11098499 0.913 rs67073020 chr4:120152557 C/T cg09307838 chr4:120376055 NA 0.6 11.44 0.41 1.08e-27 Corneal astigmatism; BRCA cis rs7172677 0.737 rs7169545 chr15:75436123 A/G cg10253484 chr15:75165896 SCAMP2 -0.45 -8.34 -0.31 4.42e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs881375 0.967 rs1008381 chr9:123681116 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 10.97 0.4 9.14e-26 Rheumatoid arthritis; BRCA trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg23533926 chr12:111358616 MYL2 -0.42 -8.86 -0.33 7.72e-18 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.43e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs939658 0.805 rs11631590 chr15:79446199 C/T cg17916960 chr15:79447300 NA -0.47 -12.17 -0.43 8.61e-31 Refractive error; BRCA cis rs2014572 1.000 rs3746231 chr19:57760057 G/A cg24459738 chr19:57751996 ZNF805 -0.36 -8.37 -0.31 3.76e-16 Hyperactive-impulsive symptoms; BRCA cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.51 -0.41 5.7e-28 Electroencephalogram traits; BRCA cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg04450456 chr4:17643702 FAM184B 0.38 11.29 0.41 4.51e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg11742103 chr11:62369870 EML3;MTA2 0.48 12.68 0.45 5.16e-33 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg22907277 chr7:1156413 C7orf50 0.6 9.01 0.34 2.28e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7811142 1.000 rs74460138 chr7:100027339 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 21.71 0.65 9.89e-79 Platelet count; BRCA cis rs9325144 0.555 rs4882284 chr12:38710459 C/T cg26384229 chr12:38710491 ALG10B -0.55 -13.88 -0.48 1.82e-38 Morning vs. evening chronotype; BRCA cis rs3768617 0.510 rs10797851 chr1:183098001 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs10751667 0.580 rs10751664 chr11:927077 T/G cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA cis rs2204008 0.837 rs11612397 chr12:38357455 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.49 0.38 7.33e-24 Bladder cancer; BRCA cis rs6545883 0.931 rs778765 chr2:61786385 A/T cg15711740 chr2:61764176 XPO1 -0.55 -13.92 -0.48 1.12e-38 Tuberculosis; BRCA cis rs6088590 1.000 rs55753039 chr20:33394940 C/T cg08999081 chr20:33150536 PIGU 0.38 9.8 0.36 3.22e-21 Coronary artery disease; BRCA cis rs4363385 0.747 rs1611760 chr1:152957573 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.29 -0.34 2.43e-19 Inflammatory skin disease; BRCA cis rs7493 0.950 rs6961624 chr7:95037661 T/C cg19678392 chr7:94953810 PON1 -0.42 -9.11 -0.34 1.03e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs6952808 0.595 rs3778983 chr7:2166319 T/G cg04565464 chr8:145669602 NFKBIL2 0.37 8.72 0.33 2.43e-17 Bipolar disorder and schizophrenia; BRCA cis rs2832191 1.000 rs2832184 chr21:30483265 C/T cg08807101 chr21:30365312 RNF160 -0.57 -13.92 -0.48 1.12e-38 Dental caries; BRCA cis rs7615952 0.599 rs2333408 chr3:125732098 G/A cg15145296 chr3:125709740 NA -0.52 -8.91 -0.33 5.31e-18 Blood pressure (smoking interaction); BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -8.23 -0.31 1.05e-15 Total body bone mineral density; BRCA cis rs17818399 0.749 rs4142759 chr2:46783890 A/G cg02822958 chr2:46747628 ATP6V1E2 0.58 10.9 0.4 1.69e-25 Height; BRCA cis rs9291683 0.530 rs17246501 chr4:9985710 A/C cg11266682 chr4:10021025 SLC2A9 0.42 11.1 0.4 2.56e-26 Bone mineral density; BRCA cis rs6723226 0.766 rs398290 chr2:32503526 T/C cg02381751 chr2:32503542 YIPF4 0.73 16.16 0.54 1.74e-49 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg20503657 chr10:835505 NA 1.01 15.58 0.52 1.25e-46 Eosinophil percentage of granulocytes; BRCA cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg14530993 chr4:882597 GAK 0.61 9.95 0.37 8.58e-22 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.583 rs7765833 chr6:25712433 C/A cg17691542 chr6:26056736 HIST1H1C 0.41 8.4 0.32 2.99e-16 Iron status biomarkers; BRCA cis rs6964587 0.773 rs10488514 chr7:91951842 C/A cg01689657 chr7:91764605 CYP51A1 0.23 8.15 0.31 1.97e-15 Breast cancer; BRCA cis rs939658 0.776 rs4778925 chr15:79443791 C/T cg17916960 chr15:79447300 NA -0.45 -11.09 -0.4 2.94e-26 Refractive error; BRCA cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4363385 0.818 rs382653 chr1:153006761 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.57 -0.32 7.61e-17 Inflammatory skin disease; BRCA cis rs243505 0.898 rs243543 chr7:148402984 C/G cg09806900 chr7:148480153 CUL1 -0.39 -8.09 -0.3 3.11e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3733585 0.673 rs9994266 chr4:9954450 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.52 -0.38 5.69e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs11676348 0.811 rs13027120 chr2:219020914 C/T cg20019365 chr2:219134978 PNKD;AAMP 0.43 9.18 0.34 5.8e-19 Ulcerative colitis; BRCA cis rs72615157 0.664 rs6953580 chr7:99825275 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.53 8.69 0.33 2.99e-17 Lung function (FEV1/FVC); BRCA cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24110177 chr3:50126178 RBM5 -0.4 -10.95 -0.4 1.11e-25 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs35378740 chr7:65987712 C/A cg11764359 chr7:65958608 NA 0.76 16.79 0.55 1.14e-52 Aortic root size; BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg25036284 chr2:26402008 FAM59B -0.77 -12.0 -0.43 4.62e-30 Gut microbiome composition (summer); BRCA cis rs6835098 0.924 rs7672108 chr4:174165126 A/G cg08422745 chr4:174089978 GALNT7 0.69 14.29 0.49 2.24e-40 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1153858 1.000 rs9783731 chr15:45642884 C/T cg14582100 chr15:45693742 SPATA5L1 -0.36 -11.62 -0.42 1.97e-28 Homoarginine levels; BRCA cis rs775227 0.574 rs66866534 chr3:113147315 T/C cg18753928 chr3:113234510 CCDC52 -0.57 -9.55 -0.35 2.63e-20 Dental caries; BRCA trans rs11098499 0.954 rs2306455 chr4:120421969 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.99 0.3 6.52e-15 Corneal astigmatism; BRCA cis rs11690935 0.959 rs7597387 chr2:172577116 T/C cg13550731 chr2:172543902 DYNC1I2 -0.91 -30.72 -0.77 6.03e-128 Schizophrenia; BRCA cis rs6545883 0.965 rs2305156 chr2:61729268 T/C cg15711740 chr2:61764176 XPO1 -0.55 -14.07 -0.49 2.38e-39 Tuberculosis; BRCA cis rs10911363 0.592 rs2702178 chr1:183452545 G/A cg09173681 chr1:183549694 NCF2 0.49 10.7 0.39 1.05e-24 Systemic lupus erythematosus; BRCA cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg04727924 chr7:799746 HEATR2 -0.56 -11.14 -0.4 1.88e-26 Cerebrospinal P-tau181p levels; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs7520050 0.807 rs3013595 chr1:46153203 G/A cg24296786 chr1:45957014 TESK2 -0.47 -10.86 -0.39 2.42e-25 Red blood cell count;Reticulocyte count; BRCA cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.44 0.35 6.85e-20 Tonsillectomy; BRCA cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg17366294 chr4:99064904 C4orf37 0.52 11.45 0.41 9.76e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.679 rs6686286 chr1:152984562 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.65 -0.32 4.31e-17 Inflammatory skin disease; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg21782813 chr7:2030301 MAD1L1 0.33 8.96 0.33 3.68e-18 Bipolar disorder and schizophrenia; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.37 -0.44 1.18e-31 Lymphocyte counts; BRCA cis rs7044106 0.762 rs7849566 chr9:123460769 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.67 14.59 0.5 8.31e-42 Hip circumference adjusted for BMI; BRCA cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg26769984 chr7:1090371 C7orf50 0.49 9.14 0.34 7.91e-19 Bronchopulmonary dysplasia; BRCA cis rs6987853 0.787 rs2923441 chr8:42429937 G/T cg09913449 chr8:42400586 C8orf40 -0.38 -7.99 -0.3 6.18e-15 Mean corpuscular hemoglobin concentration; BRCA trans rs7824557 0.806 rs6601574 chr8:11094885 G/A cg15556689 chr8:8085844 FLJ10661 -0.35 -8.54 -0.32 9.84e-17 Retinal vascular caliber; BRCA cis rs9818758 0.607 rs61729488 chr3:49067904 T/C cg01304814 chr3:48885189 PRKAR2A 0.72 7.9 0.3 1.2e-14 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs74181299 0.892 rs2249105 chr2:65287896 C/T cg05010058 chr2:65284262 CEP68 -0.3 -8.58 -0.32 7.06e-17 Pulse pressure; BRCA cis rs7772486 0.641 rs2253757 chr6:146199686 C/T cg13319975 chr6:146136371 FBXO30 -0.62 -14.54 -0.5 1.44e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs9914988 0.943 rs9890377 chr17:27111111 A/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.84 -0.33 9.22e-18 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs3761847 0.622 rs1323471 chr9:123826315 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.31 0.31 5.61e-16 Rheumatoid arthritis; BRCA cis rs7011049 1.000 rs72643600 chr8:53854530 T/G cg26025543 chr8:53854495 NA 0.55 9.49 0.35 4.66e-20 Systolic blood pressure; BRCA cis rs9790314 1.000 rs7647327 chr3:161016421 T/C cg04691961 chr3:161091175 C3orf57 -0.56 -13.42 -0.47 2.31e-36 Morning vs. evening chronotype; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg12000995 chr2:27665139 KRTCAP3 -0.35 -8.87 -0.33 7.53e-18 Total body bone mineral density; BRCA cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg14983838 chr19:29218262 NA 0.54 9.75 0.36 5.1e-21 Methadone dose in opioid dependence; BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.05 21.83 0.65 2.38e-79 Gut microbiome composition (summer); BRCA cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg25110423 chr6:41068646 NFYA;LOC221442 0.35 7.99 0.3 6.36e-15 Alzheimer's disease (late onset); BRCA cis rs6831352 0.959 rs6532796 chr4:100042242 C/T cg13256891 chr4:100009986 ADH5 -0.48 -9.17 -0.34 6.17e-19 Alcohol dependence; BRCA cis rs4919087 1.000 rs10786330 chr10:99074959 C/A cg25902810 chr10:99078978 FRAT1 0.52 11.25 0.41 6.57e-27 Monocyte count; BRCA cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg22974920 chr21:40686053 BRWD1 -0.35 -7.89 -0.3 1.35e-14 Menarche (age at onset); BRCA cis rs35306767 0.903 rs765867 chr10:869901 G/T cg20503657 chr10:835505 NA 1.03 18.17 0.58 9.16e-60 Eosinophil percentage of granulocytes; BRCA cis rs477692 0.905 rs7905466 chr10:131438937 A/T cg24747557 chr10:131355152 MGMT 0.31 8.06 0.3 3.76e-15 Response to temozolomide; BRCA cis rs1953600 0.837 rs2236556 chr10:81932790 T/C cg04850286 chr10:81895943 PLAC9 0.32 8.98 0.33 2.93e-18 Sarcoidosis; BRCA cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg21573476 chr21:45109991 RRP1B -0.35 -8.89 -0.33 6.24e-18 Mean corpuscular volume; BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg22920501 chr2:26401640 FAM59B -0.85 -16.06 -0.54 5.38e-49 Gut microbiome composition (summer); BRCA trans rs2018683 0.768 rs10282015 chr7:29022138 G/A cg19402173 chr7:128379420 CALU -0.47 -11.3 -0.41 4.07e-27 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs9815354 0.812 rs59583650 chr3:41809063 A/G cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs317689 0.918 rs581911 chr12:69738293 C/T cg20891283 chr12:69753455 YEATS4 0.53 10.91 0.4 1.58e-25 Response to diuretic therapy; BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 10.65 0.39 1.72e-24 Platelet count; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.01 -18.69 -0.59 1.63e-62 Gut microbiome composition (summer); BRCA cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.5 -11.04 -0.4 4.74e-26 IgG glycosylation; BRCA cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg25801113 chr15:45476975 SHF 0.31 7.83 0.3 2e-14 Uric acid levels; BRCA cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg00750074 chr16:89608354 SPG7 -0.42 -11.24 -0.41 7.08e-27 Multiple myeloma (IgH translocation); BRCA cis rs2836974 0.897 rs34394827 chr21:40528087 T/C cg11644478 chr21:40555479 PSMG1 0.82 18.56 0.59 8.19e-62 Cognitive function; BRCA cis rs757110 0.770 rs11024271 chr11:17395540 T/C cg04705435 chr11:17411270 KCNJ11 0.44 9.44 0.35 6.91e-20 Type 2 diabetes; BRCA cis rs6088580 0.634 rs1890000 chr20:32968312 G/T cg06115741 chr20:33292138 TP53INP2 -0.38 -8.51 -0.32 1.24e-16 Glomerular filtration rate (creatinine); BRCA cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg26343298 chr8:95960752 TP53INP1 0.3 8.77 0.33 1.57e-17 Type 2 diabetes; BRCA cis rs910873 0.505 rs67260051 chr20:33448417 C/T cg16810054 chr20:33298113 TP53INP2 0.47 10.3 0.38 3.91e-23 Melanoma; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg21782813 chr7:2030301 MAD1L1 0.43 12.34 0.44 1.53e-31 Bipolar disorder and schizophrenia; BRCA trans rs1005277 0.579 rs2008449 chr10:38414204 A/T cg17830980 chr10:43048298 ZNF37B 0.54 13.26 0.46 1.25e-35 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs13046373 0.535 rs9977510 chr21:32027920 A/G cg16431978 chr21:31797932 KRTAP13-3 0.35 8.64 0.32 4.4e-17 HDL cholesterol; BRCA trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg11693508 chr17:37793320 STARD3 0.65 13.15 0.46 4.1e-35 Bipolar disorder; BRCA cis rs6500602 0.564 rs3747584 chr16:4516092 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.43 9.0 0.34 2.51e-18 Schizophrenia; BRCA cis rs12618769 0.597 rs72821920 chr2:99111591 A/G cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA trans rs1005277 0.505 rs200939 chr10:38139483 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -9.61 -0.36 1.65e-20 Extrinsic epigenetic age acceleration; BRCA cis rs6121246 0.512 rs45443696 chr20:30311396 A/C cg13852791 chr20:30311386 BCL2L1 0.97 23.22 0.68 6.25e-87 Mean corpuscular hemoglobin; BRCA cis rs6089829 0.962 rs3746749 chr20:61667333 T/C cg08564027 chr20:61660810 NA 0.84 22.75 0.67 2.34e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs7824557 0.815 rs2736372 chr8:11106041 T/C cg21775007 chr8:11205619 TDH -0.4 -8.74 -0.33 2.09e-17 Retinal vascular caliber; BRCA cis rs12188164 0.543 rs2672722 chr5:453567 G/A cg26850624 chr5:429559 AHRR 0.33 7.98 0.3 6.89e-15 Cystic fibrosis severity; BRCA cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg05347473 chr6:146136440 FBXO30 -0.6 -11.51 -0.41 5.21e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs4787491 0.704 rs66467443 chr16:30050494 G/A cg06326092 chr16:30034487 C16orf92 0.35 8.91 0.33 5.18e-18 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs35110281 0.774 rs141521 chr21:44963686 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.44 0.32 2.16e-16 Mean corpuscular volume; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg15112475 chr7:1198522 ZFAND2A -0.58 -14.11 -0.49 1.58e-39 Longevity;Endometriosis; BRCA cis rs12472274 0.817 rs12621791 chr2:239104061 G/A cg17459225 chr2:239074497 NA 0.63 12.88 0.45 6.5e-34 Phospholipid levels (plasma); BRCA cis rs61656020 1 rs61656020 chr16:1882221 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.66 -12.94 -0.46 3.67e-34 Ankle injury; BRCA trans rs9858542 0.953 rs11715915 chr3:49455330 A/G cg21659725 chr3:3221576 CRBN 0.46 9.49 0.35 4.62e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg04450456 chr4:17643702 FAM184B 0.42 12.53 0.44 2.37e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3820928 0.874 rs10188770 chr2:227877037 G/A cg11843606 chr2:227700838 RHBDD1 -0.37 -8.09 -0.3 2.95e-15 Pulmonary function; BRCA cis rs2797160 1.000 rs1739375 chr6:126012013 T/C cg05901451 chr6:126070800 HEY2 0.4 9.69 0.36 8.1e-21 Endometrial cancer; BRCA trans rs79976124 0.837 rs12201218 chr6:66653619 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.6 -10.82 -0.39 3.59e-25 Type 2 diabetes; BRCA cis rs7301826 0.580 rs12821464 chr12:131322719 T/G cg11011512 chr12:131303247 STX2 -0.45 -11.0 -0.4 6.56e-26 Plasma plasminogen activator levels; BRCA cis rs12367572 1.000 rs12822444 chr12:45276677 G/A cg04608330 chr12:45269318 NELL2 -0.62 -13.76 -0.48 6.36e-38 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs4699600 chr4:99019429 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4862750 0.914 rs1991256 chr4:187875330 A/G cg03452623 chr4:187889614 NA -0.35 -11.44 -0.41 1.08e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg22800045 chr5:56110881 MAP3K1 -0.5 -8.41 -0.32 2.59e-16 Initial pursuit acceleration; BRCA cis rs17376456 0.825 rs13164315 chr5:93147421 A/G cg25358565 chr5:93447407 FAM172A 1.17 18.19 0.58 6.98e-60 Diabetic retinopathy; BRCA cis rs9399137 0.507 rs13197750 chr6:135312380 G/A cg24558204 chr6:135376177 HBS1L 0.6 16.25 0.54 5.98e-50 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg26647111 chr11:31128758 NA -0.44 -9.61 -0.36 1.63e-20 Red blood cell count; BRCA cis rs1784581 0.706 rs9346895 chr6:162431168 T/C cg17173639 chr6:162384350 PARK2 0.37 8.75 0.33 1.96e-17 Itch intensity from mosquito bite; BRCA cis rs1552244 0.882 rs13063929 chr3:10010308 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 17.32 0.57 2.22e-55 Alzheimer's disease; BRCA cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg08917208 chr2:24149416 ATAD2B 0.91 13.42 0.47 2.48e-36 Lymphocyte counts; BRCA trans rs3749237 0.964 rs2234385 chr3:49846041 G/A cg21659725 chr3:3221576 CRBN 0.51 12.26 0.44 3.67e-31 Resting heart rate; BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.95 0.33 3.76e-18 Tonsillectomy; BRCA cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg07952391 chr2:88470173 THNSL2 -0.39 -7.95 -0.3 8.48e-15 Response to metformin (IC50); BRCA cis rs8062405 1.000 rs62037369 chr16:28883841 C/T cg09754948 chr16:28834200 ATXN2L 0.46 8.45 0.32 2.02e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs801193 0.844 rs732465 chr7:65998450 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.4 8.76 0.33 1.73e-17 Aortic root size; BRCA cis rs1218582 0.772 rs6683557 chr1:154852307 C/G cg24250549 chr1:154909240 PMVK 0.69 18.08 0.58 2.42e-59 Prostate cancer; BRCA cis rs870825 0.616 rs7700216 chr4:185648510 G/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs72928364 0.929 rs13065684 chr3:100773738 T/C cg10123952 chr3:100791384 NA 0.58 8.43 0.32 2.3e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg20503657 chr10:835505 NA 1.3 21.68 0.65 1.61e-78 Eosinophil percentage of granulocytes; BRCA cis rs6546537 0.824 rs3771543 chr2:69784255 C/T cg10773587 chr2:69614142 GFPT1 -0.42 -8.85 -0.33 8.42e-18 Serum thyroid-stimulating hormone levels; BRCA cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.86 -0.3 1.61e-14 Electroencephalogram traits; BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.17 -0.31 1.62e-15 Gut microbiome composition (summer); BRCA cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg26384229 chr12:38710491 ALG10B 0.6 16.64 0.55 6.53e-52 Heart rate; BRCA cis rs2836974 0.583 rs2735307 chr21:40713358 C/T cg11644478 chr21:40555479 PSMG1 0.53 11.58 0.42 2.72e-28 Cognitive function; BRCA cis rs703842 1.000 rs10431505 chr12:58178589 A/G cg00677455 chr12:58241039 CTDSP2 0.63 15.48 0.52 4.01e-46 Multiple sclerosis; BRCA cis rs17376456 0.877 rs56373208 chr5:93491276 C/A cg21475434 chr5:93447410 FAM172A 0.71 8.87 0.33 7.51e-18 Diabetic retinopathy; BRCA cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -12.23 -0.44 4.83e-31 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg26597838 chr10:835615 NA 1.03 15.79 0.53 1.13e-47 Eosinophil percentage of granulocytes; BRCA cis rs3096299 0.933 rs28608022 chr16:89454292 C/T cg06640241 chr16:89574553 SPG7 0.6 13.17 0.46 3.18e-35 Multiple myeloma (IgH translocation); BRCA cis rs7914558 1.000 rs7911789 chr10:104756374 T/C cg04362960 chr10:104952993 NT5C2 0.43 10.37 0.38 2.12e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs921968 0.541 rs6710383 chr2:219359685 T/G cg02176678 chr2:219576539 TTLL4 0.45 11.62 0.42 1.97e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.98 -0.3 6.75e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg21724239 chr8:58056113 NA 0.58 9.23 0.34 3.88e-19 Developmental language disorder (linguistic errors); BRCA cis rs56399783 0.901 rs79932907 chr7:2827901 C/G cg19731401 chr7:2775893 GNA12 0.51 8.33 0.31 4.77e-16 Childhood ear infection; BRCA cis rs6973256 0.897 rs10236819 chr7:133345983 A/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.95 -0.33 3.96e-18 Intelligence (multi-trait analysis); BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg03188948 chr7:1209495 NA 0.82 11.41 0.41 1.43e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.62 -0.32 5.36e-17 Total body bone mineral density; BRCA cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg23978390 chr7:1156363 C7orf50 0.49 10.3 0.38 4.14e-23 Bronchopulmonary dysplasia; BRCA cis rs4319547 1.000 rs6489156 chr12:123100397 C/T cg23029597 chr12:123009494 RSRC2 -0.59 -12.41 -0.44 8.01e-32 Body mass index; BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 19.95 0.62 3.51e-69 Platelet count; BRCA trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21659725 chr3:3221576 CRBN 0.46 11.51 0.41 5.58e-28 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg03213289 chr20:61660250 NA 0.62 16.31 0.54 3.07e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg05623727 chr3:50126028 RBM5 -0.41 -9.9 -0.36 1.3e-21 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.673 rs4697914 chr4:9952266 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.32 -0.38 3.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7715806 0.500 rs17563974 chr5:75004175 G/A cg19683494 chr5:74908142 NA 0.53 8.64 0.32 4.46e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6684428 0.706 rs11206677 chr1:56335237 C/A cg11651538 chr1:56320950 NA -0.49 -8.41 -0.32 2.66e-16 Airflow obstruction; BRCA cis rs2652834 0.808 rs4775614 chr15:63351687 A/G cg05507819 chr15:63340323 TPM1 0.53 9.22 0.34 4.21e-19 HDL cholesterol; BRCA trans rs1005277 0.579 rs2983343 chr10:38383332 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.57 -0.32 7.8e-17 Extrinsic epigenetic age acceleration; BRCA cis rs9287719 0.967 rs6706542 chr2:10742491 A/C cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs12545109 0.800 rs2610052 chr8:57411316 C/A cg09654669 chr8:57350985 NA -0.39 -8.45 -0.32 1.98e-16 Obesity-related traits; BRCA cis rs7927771 0.832 rs10769262 chr11:47411581 G/A cg20307385 chr11:47447363 PSMC3 0.4 8.44 0.32 2.1e-16 Subjective well-being; BRCA cis rs6546550 0.901 rs6739780 chr2:70138111 G/A cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.93e-28 Prevalent atrial fibrillation; BRCA cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg25767906 chr1:53392781 SCP2 0.43 9.78 0.36 3.87e-21 Monocyte count; BRCA cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg10295955 chr4:187884368 NA -0.97 -28.35 -0.75 4.32e-115 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 1.000 rs28409322 chr3:134252385 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 12.07 0.43 2.33e-30 Tonsillectomy; BRCA cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.2 0.37 9.88e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7824557 0.737 rs2293855 chr8:11177410 G/A cg15556689 chr8:8085844 FLJ10661 0.39 9.29 0.34 2.31e-19 Retinal vascular caliber; BRCA cis rs921968 0.540 rs6746040 chr2:219588890 G/T cg02176678 chr2:219576539 TTLL4 -0.42 -11.18 -0.4 1.21e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs829883 0.639 rs829898 chr12:98857675 A/C cg25150519 chr12:98850993 NA 0.68 16.46 0.55 5.41e-51 Colorectal adenoma (advanced); BRCA trans rs9944715 1.000 rs9944767 chr18:43831057 A/G cg01718231 chr17:29326311 RNF135 0.46 8.99 0.34 2.78e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs501916 0.605 rs11632156 chr15:48082099 A/G cg16110827 chr15:48056943 SEMA6D -0.38 -8.13 -0.31 2.29e-15 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs6121246 0.909 rs1994250 chr20:30287494 A/G cg13852791 chr20:30311386 BCL2L1 0.86 16.78 0.55 1.31e-52 Mean corpuscular hemoglobin; BRCA cis rs372883 0.583 rs117214 chr21:30720834 A/G cg08807101 chr21:30365312 RNF160 0.34 8.03 0.3 4.57e-15 Pancreatic cancer; BRCA cis rs1707322 0.721 rs11211166 chr1:46157942 G/A cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg24060327 chr5:131705240 SLC22A5 -0.62 -11.71 -0.42 7.9e-29 Breast cancer; BRCA cis rs4077515 0.967 rs11145874 chr9:139290011 G/A cg14019695 chr9:139328340 INPP5E 0.31 8.14 0.31 2.11e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg27478167 chr7:817139 HEATR2 -0.42 -8.94 -0.33 4.01e-18 Cerebrospinal P-tau181p levels; BRCA cis rs6121246 0.559 rs1484994 chr20:30305975 A/G cg13852791 chr20:30311386 BCL2L1 0.96 23.15 0.68 1.5e-86 Mean corpuscular hemoglobin; BRCA cis rs2921036 0.545 rs4840975 chr8:8363258 C/T cg15556689 chr8:8085844 FLJ10661 -0.31 -7.9 -0.3 1.19e-14 Neuroticism; BRCA cis rs35110281 0.805 rs4818855 chr21:45038951 C/T cg04455712 chr21:45112962 RRP1B 0.39 10.55 0.39 4.17e-24 Mean corpuscular volume; BRCA cis rs273218 0.573 rs16882051 chr5:53342979 T/C ch.5.1024479R chr5:53302184 ARL15 -0.73 -13.71 -0.48 1.12e-37 Migraine; BRCA cis rs274567 0.501 rs581968 chr5:131710202 G/A cg07395648 chr5:131743802 NA 0.38 8.23 0.31 1.02e-15 Blood metabolite levels; BRCA cis rs12997796 1.000 rs12997796 chr2:86974318 A/G cg25203885 chr2:87302643 LOC285074 -0.47 -8.22 -0.31 1.13e-15 Schizophrenia; BRCA cis rs17601876 0.814 rs7181429 chr15:51559496 G/A cg19946085 chr15:51559439 CYP19A1 -0.38 -11.59 -0.42 2.51e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA trans rs7200543 1.000 rs16966953 chr16:15135854 A/G cg24683922 chr1:11983373 KIAA2013 -0.37 -8.45 -0.32 1.97e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs1499614 1.000 rs1267818 chr7:66107024 C/T cg18252515 chr7:66147081 NA -1.06 -15.53 -0.52 2.19e-46 Gout; BRCA cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg21724239 chr8:58056113 NA 0.64 15.16 0.51 1.41e-44 Developmental language disorder (linguistic errors); BRCA cis rs4820539 1.000 rs916584 chr22:23469433 A/G cg14186256 chr22:23484241 RTDR1 0.77 23.78 0.69 5.07e-90 Bone mineral density; BRCA cis rs1451375 1.000 rs1451375 chr7:50622712 A/C cg18232548 chr7:50535776 DDC -0.44 -10.04 -0.37 3.86e-22 Malaria; BRCA cis rs801193 0.527 rs2707837 chr7:66181073 G/C cg11764359 chr7:65958608 NA 0.74 16.68 0.55 3.87e-52 Aortic root size; BRCA cis rs12971120 0.891 rs3794953 chr18:72180519 C/T cg25817165 chr18:72167213 CNDP2 -0.72 -12.62 -0.45 9.39e-33 Refractive error; BRCA cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg21518248 chr2:162101506 NA 0.71 17.56 0.57 1.2e-56 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs1506636 1.000 rs12706545 chr7:123348744 C/T cg03229431 chr7:123269106 ASB15 -0.6 -14.0 -0.48 4.74e-39 Plateletcrit;Platelet count; BRCA cis rs6782228 0.606 rs6787559 chr3:128381086 T/C cg16766828 chr3:128327626 NA -0.44 -9.8 -0.36 3.11e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs1372520 0.684 rs1837891 chr4:90736131 C/G cg15133208 chr4:90757351 SNCA 0.38 7.89 0.3 1.33e-14 Neuroticism; BRCA cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg08085267 chr17:45401833 C17orf57 0.6 12.31 0.44 2.05e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg23285459 chr7:2802560 GNA12 0.35 8.57 0.32 7.76e-17 Height; BRCA cis rs2046867 0.862 rs6766747 chr3:72856551 T/C cg25664220 chr3:72788482 NA -0.53 -11.1 -0.4 2.62e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg03264133 chr6:25882463 NA -0.77 -16.71 -0.55 2.88e-52 Intelligence (multi-trait analysis); BRCA cis rs28374715 0.532 rs28897479 chr15:41690851 T/G cg18705301 chr15:41695430 NDUFAF1 -1.1 -24.83 -0.7 9.11e-96 Ulcerative colitis; BRCA cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg00012203 chr2:219082015 ARPC2 -0.43 -8.31 -0.31 5.77e-16 Ulcerative colitis; BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg02951883 chr7:2050386 MAD1L1 -0.37 -8.91 -0.33 5.4e-18 Bipolar disorder and schizophrenia; BRCA cis rs7264396 0.790 rs3787164 chr20:34228866 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.22 0.31 1.13e-15 Total cholesterol levels; BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs3857536 0.740 rs7763555 chr6:66889930 C/T cg07460842 chr6:66804631 NA -0.47 -9.09 -0.34 1.25e-18 Blood trace element (Cu levels); BRCA cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg26647111 chr11:31128758 NA -0.44 -9.59 -0.35 1.97e-20 Red blood cell count; BRCA cis rs13108904 0.518 rs4974603 chr4:1343168 C/T cg13395646 chr4:1353034 KIAA1530 -0.48 -9.03 -0.34 2.06e-18 Obesity-related traits; BRCA cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg12463550 chr7:65579703 CRCP -0.37 -7.99 -0.3 6.48e-15 Aortic root size; BRCA cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg20503657 chr10:835505 NA 0.89 13.76 0.48 6.13e-38 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11644478 chr21:40555479 PSMG1 -0.67 -15.11 -0.51 2.37e-44 Cognitive function; BRCA cis rs7914558 1.000 rs1890184 chr10:104748459 A/C cg04362960 chr10:104952993 NT5C2 0.43 10.45 0.38 1.08e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs10489202 1.000 rs17485889 chr1:168018840 G/T cg24449463 chr1:168025552 DCAF6 -0.41 -11.14 -0.4 1.84e-26 Schizophrenia; BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg25062951 chr7:817576 HEATR2 -0.38 -7.8 -0.3 2.45e-14 Cerebrospinal P-tau181p levels; BRCA cis rs12950390 0.893 rs11079789 chr17:45849715 A/G cg03474202 chr17:45855739 NA -0.47 -12.56 -0.45 1.65e-32 IgG glycosylation; BRCA cis rs769267 0.965 rs4808938 chr19:19401218 G/A cg01262667 chr19:19385393 TM6SF2 0.41 10.57 0.39 3.41e-24 Tonsillectomy; BRCA cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.35 0.38 2.49e-23 Electroencephalogram traits; BRCA cis rs6430585 0.527 rs961360 chr2:136393658 A/G cg07169764 chr2:136633963 MCM6 0.98 19.22 0.61 2.58e-65 Corneal structure; BRCA cis rs9815354 0.812 rs10510733 chr3:42009192 T/C cg03022575 chr3:42003672 ULK4 0.73 10.09 0.37 2.48e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.2 0.6 3.14e-65 Alzheimer's disease; BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg26119090 chr2:26468346 HADHA;HADHB 0.74 11.43 0.41 1.14e-27 Gut microbiome composition (summer); BRCA cis rs10754283 0.967 rs10801757 chr1:90103080 A/G cg21401794 chr1:90099060 LRRC8C 0.45 11.03 0.4 5.11e-26 Amyotrophic lateral sclerosis (sporadic); BRCA trans rs11098499 0.708 rs11732686 chr4:120252330 C/A cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 9.97e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg22875332 chr1:76189707 ACADM -0.48 -9.18 -0.34 5.87e-19 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3762637 0.943 rs9872708 chr3:122242807 C/G cg24169773 chr3:122142474 KPNA1 -0.43 -8.01 -0.3 5.54e-15 LDL cholesterol levels; BRCA cis rs13191362 0.872 rs13196631 chr6:163001588 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.81 12.37 0.44 1.14e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2204008 0.811 rs4882300 chr12:38415224 A/T cg06521331 chr12:34319734 NA 0.47 9.31 0.35 1.98e-19 Bladder cancer; BRCA cis rs1113500 0.933 rs11185261 chr1:108638703 G/A cg06207961 chr1:108661230 NA 0.44 10.84 0.39 2.89e-25 Growth-regulated protein alpha levels; BRCA cis rs6121246 0.909 rs3203770 chr20:30382315 A/G cg13852791 chr20:30311386 BCL2L1 0.84 16.41 0.54 9.67e-51 Mean corpuscular hemoglobin; BRCA cis rs12477438 0.520 rs1044575 chr2:99812070 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.78 0.73 1.74e-106 Chronic sinus infection; BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.82 0.42 2.6e-29 Tonsillectomy; BRCA trans rs11098499 0.908 rs11098527 chr4:120399906 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.88 -0.3 1.39e-14 Corneal astigmatism; BRCA cis rs4853036 1.000 rs13020991 chr2:70068642 A/G cg02498382 chr2:70120550 SNRNP27 -0.51 -9.35 -0.35 1.51e-19 Colorectal or endometrial cancer; BRCA cis rs992157 0.700 rs10165153 chr2:219159629 T/C cg20019365 chr2:219134978 PNKD;AAMP 0.53 11.38 0.41 1.83e-27 Colorectal cancer; BRCA cis rs2404602 0.647 rs11072628 chr15:77107761 C/A cg23625390 chr15:77176239 SCAPER -0.55 -12.83 -0.45 1.08e-33 Blood metabolite levels; BRCA cis rs1829883 0.717 rs2682166 chr5:98888088 A/G cg08333243 chr5:99726346 NA -0.36 -8.16 -0.31 1.75e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs7772486 0.790 rs2247429 chr6:146217769 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.33 -0.35 1.65e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs9311474 0.597 rs13303 chr3:52558008 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.27 8.7 0.33 2.73e-17 Electroencephalogram traits; BRCA cis rs40363 0.645 rs250633 chr16:3523002 C/T cg00484396 chr16:3507460 NAT15 0.44 9.33 0.35 1.78e-19 Tuberculosis; BRCA cis rs172166 0.694 rs203876 chr6:28046673 T/C cg10876282 chr6:28092338 ZSCAN16 0.42 8.39 0.31 3.14e-16 Cardiac Troponin-T levels; BRCA cis rs7520050 0.931 rs11211189 chr1:46261584 A/T cg24296786 chr1:45957014 TESK2 0.44 9.96 0.37 8.03e-22 Red blood cell count;Reticulocyte count; BRCA cis rs11785693 0.862 rs7009771 chr8:4990189 C/T cg26367366 chr8:4980734 NA 0.6 10.7 0.39 1.09e-24 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.01 0.34 2.36e-18 Motion sickness; BRCA cis rs250677 0.687 rs41181 chr5:148444257 C/G cg23229984 chr5:148520753 ABLIM3 -0.36 -8.86 -0.33 8.16e-18 Breast cancer; BRCA cis rs9858542 1.000 rs13316695 chr3:49684917 C/G cg03060546 chr3:49711283 APEH -0.61 -12.3 -0.44 2.28e-31 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6598955 0.671 rs12129482 chr1:26623641 C/T cg00852783 chr1:26633632 UBXN11 -0.47 -8.51 -0.32 1.22e-16 Obesity-related traits; BRCA cis rs911119 1.000 rs73318135 chr20:23618571 T/G cg16589663 chr20:23618590 CST3 0.46 8.72 0.33 2.36e-17 Chronic kidney disease; BRCA cis rs17376456 0.825 rs1470150 chr5:93138654 C/T cg21475434 chr5:93447410 FAM172A -0.57 -7.89 -0.3 1.27e-14 Diabetic retinopathy; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs769267 0.896 rs7250893 chr19:19625547 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.05 0.34 1.69e-18 Tonsillectomy; BRCA cis rs2731664 0.765 rs2630766 chr5:176874941 A/C cg23176889 chr5:176863531 GRK6 -0.63 -17.62 -0.57 6.5e-57 Intelligence (multi-trait analysis); BRCA cis rs9368481 0.761 rs4713062 chr6:26948195 A/G cg12292205 chr6:26970375 C6orf41 -0.73 -16.7 -0.55 3.24e-52 Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.613 rs1525898 chr12:33904445 G/T cg26384229 chr12:38710491 ALG10B 0.41 9.17 0.34 6.33e-19 Morning vs. evening chronotype; BRCA cis rs7903847 0.620 rs954149 chr10:99122936 G/A cg08345082 chr10:99160200 RRP12 -0.28 -8.06 -0.3 3.84e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs8180040 0.966 rs7628631 chr3:47560863 C/T cg16586182 chr3:47516702 SCAP 0.55 11.51 0.41 5.69e-28 Colorectal cancer; BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.33 -0.31 4.9e-16 Blood pressure (smoking interaction); BRCA cis rs10754283 0.967 rs10737708 chr1:90119804 A/G cg21401794 chr1:90099060 LRRC8C 0.47 11.61 0.42 2.07e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs3741151 0.773 rs7110369 chr11:73160946 C/A cg17517138 chr11:73019481 ARHGEF17 0.87 12.43 0.44 6.65e-32 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs1008375 1.000 rs60178264 chr4:17685308 G/T cg15017067 chr4:17643749 FAM184B 0.31 9.64 0.36 1.27e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg26384229 chr12:38710491 ALG10B 0.78 18.0 0.58 6.47e-59 Heart rate; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg04944784 chr2:26401820 FAM59B -0.99 -17.0 -0.56 9.04e-54 Gut microbiome composition (summer); BRCA cis rs9814567 1.000 rs12637751 chr3:134266124 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs30380 0.632 rs26497 chr5:96138767 T/C cg16492584 chr5:96139282 ERAP1 -0.48 -11.23 -0.41 7.7e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs11190604 1.000 rs2295779 chr10:102296061 A/G cg07080220 chr10:102295463 HIF1AN 0.62 15.3 0.52 2.93e-45 Palmitoleic acid (16:1n-7) levels; BRCA cis rs68170813 0.559 rs10953530 chr7:106827796 A/C cg02696742 chr7:106810147 HBP1 -0.54 -8.93 -0.33 4.66e-18 Coronary artery disease; BRCA cis rs2011503 1.000 rs78010159 chr19:19615905 C/T cg15839431 chr19:19639596 YJEFN3 -0.41 -9.02 -0.34 2.19e-18 Bipolar disorder; BRCA trans rs6952808 0.594 rs3778965 chr7:2138296 G/A cg04565464 chr8:145669602 NFKBIL2 0.44 9.96 0.37 8.07e-22 Bipolar disorder and schizophrenia; BRCA cis rs344364 0.518 rs1657129 chr16:1945826 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.54 -9.64 -0.36 1.26e-20 Glomerular filtration rate in chronic kidney disease; BRCA cis rs4713118 0.513 rs149942 chr6:28001610 T/C cg10876282 chr6:28092338 ZSCAN16 0.41 8.13 0.31 2.17e-15 Parkinson's disease; BRCA cis rs765787 0.530 rs11636367 chr15:45535862 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.05 0.3 4.14e-15 Uric acid levels; BRCA cis rs7647973 0.626 rs2329021 chr3:49679072 G/A cg07636037 chr3:49044803 WDR6 0.52 8.46 0.32 1.81e-16 Menarche (age at onset); BRCA cis rs10992471 0.756 rs2761681 chr9:95186937 A/G cg14631576 chr9:95140430 CENPP -0.35 -8.35 -0.31 4.17e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA trans rs12310956 0.510 rs4931759 chr12:33871969 T/C cg26384229 chr12:38710491 ALG10B 0.41 9.68 0.36 8.66e-21 Morning vs. evening chronotype; BRCA cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 8.96 0.33 3.55e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg15145296 chr3:125709740 NA -0.57 -9.37 -0.35 1.19e-19 Blood pressure (smoking interaction); BRCA cis rs1059312 1.000 rs3825180 chr12:129279242 A/G cg23521905 chr12:129298690 SLC15A4;MGC16384 -0.29 -9.59 -0.35 1.93e-20 Systemic lupus erythematosus; BRCA cis rs7617773 0.780 rs13082158 chr3:48372470 T/C cg11946769 chr3:48343235 NME6 0.67 13.41 0.47 2.67e-36 Coronary artery disease; BRCA cis rs6542838 0.611 rs6742047 chr2:99531460 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.42 -9.47 -0.35 5.33e-20 Fear of minor pain; BRCA cis rs9790314 0.905 rs7613358 chr3:160949296 T/C cg03342759 chr3:160939853 NMD3 -0.67 -15.65 -0.53 5.43e-47 Morning vs. evening chronotype; BRCA cis rs2625529 0.652 rs2957735 chr15:72265173 T/C cg16672083 chr15:72433130 SENP8 0.68 16.23 0.54 7.44e-50 Red blood cell count; BRCA cis rs1707322 0.685 rs56177313 chr1:46225806 A/C cg06784218 chr1:46089804 CCDC17 0.49 11.79 0.42 3.79e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg25326776 chr5:148520934 ABLIM3 -0.45 -8.07 -0.3 3.42e-15 Breast cancer; BRCA cis rs4965272 1.000 rs28473493 chr15:100583942 T/C cg27344315 chr15:100560801 ADAMTS17 -0.39 -8.15 -0.31 1.93e-15 Gastroesophageal reflux disease; BRCA cis rs55665837 1.000 rs10047457 chr11:14439459 T/A cg19336497 chr11:14380999 RRAS2 -0.36 -9.48 -0.35 4.83e-20 Vitamin D levels; BRCA cis rs10751667 0.666 rs10902239 chr11:946484 A/G ch.11.42038R chr11:967971 AP2A2 -0.52 -16.73 -0.55 2.28e-52 Alzheimer's disease (late onset); BRCA cis rs7607369 0.637 rs17462630 chr2:219286541 C/G cg10223061 chr2:219282414 VIL1 0.35 9.87 0.36 1.69e-21 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs9649465 0.935 rs1506641 chr7:123390143 G/A cg04330084 chr7:123175371 IQUB -0.3 -8.23 -0.31 1.04e-15 Migraine; BRCA cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.28 -0.34 2.63e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs11229555 0.645 rs4347409 chr11:58176252 C/T cg15696309 chr11:58395628 NA 0.44 9.55 0.35 2.75e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6930083 0.713 rs1321308 chr6:36638691 A/C cg08179530 chr6:36648295 CDKN1A -0.67 -15.96 -0.53 1.57e-48 Coronary artery disease; BRCA cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg03433033 chr1:76189801 ACADM 0.89 23.79 0.69 4.26e-90 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg13628971 chr7:2884303 GNA12 0.49 9.79 0.36 3.56e-21 Height; BRCA cis rs9486719 0.901 rs760619 chr6:96857431 A/G cg06623918 chr6:96969491 KIAA0776 0.75 12.94 0.46 3.34e-34 Migraine;Coronary artery disease; BRCA cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg15017067 chr4:17643749 FAM184B 0.31 9.36 0.35 1.31e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4319547 0.585 rs7953007 chr12:122816977 A/C cg23029597 chr12:123009494 RSRC2 -0.59 -11.43 -0.41 1.19e-27 Body mass index; BRCA cis rs13191362 0.935 rs67368176 chr6:162968436 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.7 0.45 3.91e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7264396 0.790 rs2425125 chr20:34330954 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.38 -8.13 -0.31 2.27e-15 Total cholesterol levels; BRCA cis rs10489202 0.583 rs203782 chr1:167882386 A/G cg24449463 chr1:168025552 DCAF6 0.52 17.99 0.58 7.95e-59 Schizophrenia; BRCA cis rs11577318 0.853 rs12728971 chr1:26626612 C/T cg00852783 chr1:26633632 UBXN11 0.5 10.79 0.39 4.83e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs7267979 0.873 rs6132822 chr20:25228695 C/T cg08601574 chr20:25228251 PYGB 0.41 9.62 0.36 1.49e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg26384229 chr12:38710491 ALG10B 0.79 20.5 0.63 3.74e-72 Heart rate; BRCA cis rs8054556 0.539 rs12596543 chr16:30029135 A/G cg06326092 chr16:30034487 C16orf92 0.34 8.52 0.32 1.12e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs250677 1.000 rs36080 chr5:148430451 A/G cg12140854 chr5:148520817 ABLIM3 -0.41 -8.81 -0.33 1.15e-17 Breast cancer; BRCA cis rs62229266 0.626 rs2835268 chr21:37449136 C/G cg12218747 chr21:37451666 NA -0.46 -11.71 -0.42 8.08e-29 Mitral valve prolapse; BRCA cis rs208520 0.586 rs208442 chr6:66900618 T/A cg07460842 chr6:66804631 NA -0.6 -11.03 -0.4 5.37e-26 Exhaled nitric oxide output; BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg04944784 chr2:26401820 FAM59B -0.84 -12.99 -0.46 2.03e-34 Gut microbiome composition (summer); BRCA cis rs1113500 0.836 rs1539553 chr1:108589998 C/T cg06207961 chr1:108661230 NA -0.39 -9.2 -0.34 5.12e-19 Growth-regulated protein alpha levels; BRCA cis rs8114671 0.562 rs959829 chr20:33346047 T/C cg07148914 chr20:33460835 GGT7 -0.43 -8.94 -0.33 4.22e-18 Height; BRCA cis rs4948102 0.653 rs6593294 chr7:56063201 G/C cg09872392 chr7:56161020 PHKG1 -0.4 -9.1 -0.34 1.1e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs6460942 0.555 rs7803268 chr7:12306793 G/A cg06484146 chr7:12443880 VWDE -0.65 -8.9 -0.33 5.91e-18 Coronary artery disease; BRCA cis rs6831352 0.589 rs2924584 chr4:99988208 A/G cg13256891 chr4:100009986 ADH5 0.48 10.77 0.39 5.87e-25 Alcohol dependence; BRCA cis rs6547741 1.000 rs6756238 chr2:27841305 G/A cg27432699 chr2:27873401 GPN1 0.44 9.31 0.35 2.01e-19 Oral cavity cancer; BRCA cis rs2836974 0.899 rs34433511 chr21:40618883 A/C cg11890956 chr21:40555474 PSMG1 1.05 29.77 0.76 8.13e-123 Cognitive function; BRCA cis rs6429082 0.715 rs2291687 chr1:235594182 A/G cg26050004 chr1:235667680 B3GALNT2 -0.55 -12.82 -0.45 1.18e-33 Adiposity; BRCA cis rs599083 0.530 rs640569 chr11:68184820 A/G cg01657329 chr11:68192670 LRP5 0.36 8.08 0.3 3.22e-15 Bone mineral density (spine); BRCA cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.96 -0.4 1.02e-25 Personality dimensions; BRCA cis rs10504229 0.953 rs66676208 chr8:58173866 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs10470893 chr4:99038756 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 2.8e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs651907 0.535 rs17347156 chr3:101504674 G/A cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.51 -0.32 1.24e-16 Colorectal cancer; BRCA cis rs4595586 0.545 rs12819186 chr12:39356912 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.54e-19 Morning vs. evening chronotype; BRCA cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg09877947 chr5:131593287 PDLIM4 0.37 7.86 0.3 1.62e-14 Breast cancer; BRCA cis rs9462027 0.651 rs7769820 chr6:34760228 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA cis rs2108225 0.934 rs2283044 chr7:107440553 A/G cg18560240 chr7:107437656 SLC26A3 0.54 11.44 0.41 1.09e-27 Ulcerative colitis; BRCA cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.09e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs654950 0.934 rs641974 chr1:42002137 G/A cg06885757 chr1:42089581 HIVEP3 -0.28 -9.81 -0.36 2.9e-21 Airway imaging phenotypes; BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg00149659 chr3:10157352 C3orf10 0.8 13.63 0.47 2.44e-37 Alzheimer's disease; BRCA trans rs60843830 1.000 rs59937473 chr2:271797 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 13.7 0.48 1.21e-37 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg05084668 chr3:125655381 ALG1L -0.47 -7.98 -0.3 6.69e-15 Blood pressure (smoking interaction); BRCA cis rs210138 0.706 rs3916279 chr6:33574950 A/C cg17865955 chr6:33601177 ITPR3 0.37 7.91 0.3 1.14e-14 Testicular germ cell tumor; BRCA cis rs7267979 1.000 rs6107045 chr20:25441936 G/A cg08601574 chr20:25228251 PYGB 0.36 8.37 0.31 3.65e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg23711669 chr6:146136114 FBXO30 0.81 19.42 0.61 2.14e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg00701064 chr4:6280414 WFS1 0.68 17.71 0.57 2.26e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7727544 0.684 rs272893 chr5:131663062 T/C cg24060327 chr5:131705240 SLC22A5 -0.47 -9.67 -0.36 1e-20 Blood metabolite levels; BRCA cis rs67072384 1.000 rs7124056 chr11:72444747 C/T cg04827223 chr11:72435913 ARAP1 0.64 10.9 0.4 1.7e-25 Alloimmunization response to red blood cell transfusion in sickle cell anemia; BRCA cis rs4927850 0.881 rs7630489 chr3:195753401 T/C cg01181863 chr3:195395398 SDHAP2 -0.46 -8.01 -0.3 5.54e-15 Pancreatic cancer; BRCA cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg04727924 chr7:799746 HEATR2 -0.54 -10.19 -0.37 1.08e-22 Cerebrospinal P-tau181p levels; BRCA cis rs801193 0.569 rs881285 chr7:66119420 A/G cg18876405 chr7:65276391 NA -0.49 -10.81 -0.39 3.81e-25 Aortic root size; BRCA cis rs6748734 1.000 rs7604393 chr2:241825034 T/G cg04034577 chr2:241836375 C2orf54 -0.57 -13.89 -0.48 1.66e-38 Urinary metabolites; BRCA cis rs933688 1.000 rs889213 chr5:90682151 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.33 0.61 6.67e-66 Smoking behavior; BRCA cis rs909002 0.849 rs2280386 chr1:32086912 A/C cg13919466 chr1:32135498 COL16A1 -0.28 -9.53 -0.35 3.22e-20 Intelligence (multi-trait analysis); BRCA cis rs10046574 0.831 rs111522774 chr7:135135327 C/A cg27474649 chr7:135195673 CNOT4 0.6 8.54 0.32 9.88e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.36 -0.41 2.25e-27 Gut microbiome composition (summer); BRCA cis rs3733585 0.699 rs4515163 chr4:9959603 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 1.000 rs10260585 chr7:1889521 G/A cg03354898 chr7:1950403 MAD1L1 -0.46 -9.19 -0.34 5.29e-19 Bipolar disorder and schizophrenia; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg23285459 chr7:2802560 GNA12 -0.38 -9.68 -0.36 8.74e-21 Height; BRCA cis rs13191362 1.000 rs67046187 chr6:163068532 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.98 14.5 0.5 2.25e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs870825 0.616 rs28450662 chr4:185638900 G/A cg04058563 chr4:185651563 MLF1IP 0.78 17.38 0.57 1.04e-55 Blood protein levels; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs3796619 0.924 rs11940546 chr4:1072485 C/T cg27284194 chr4:1044797 NA 0.44 9.44 0.35 6.9e-20 Recombination rate (males); BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 18.05 0.58 3.8e-59 Alzheimer's disease; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg23708337 chr7:1209742 NA 0.63 8.84 0.33 9.2e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7833986 0.501 rs2953910 chr8:56968761 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.38 0.47 3.61e-36 Height; BRCA trans rs7829975 0.688 rs7817376 chr8:8380530 C/T cg16141378 chr3:129829833 LOC729375 0.33 8.13 0.31 2.16e-15 Mood instability; BRCA cis rs6545883 0.525 rs2049747 chr2:61364154 G/A cg15711740 chr2:61764176 XPO1 0.45 11.04 0.4 4.76e-26 Tuberculosis; BRCA cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg11890956 chr21:40555474 PSMG1 0.96 24.22 0.69 2.01e-92 Cognitive function; BRCA cis rs7927592 0.913 rs7127948 chr11:68363062 G/A cg20283391 chr11:68216788 NA -0.45 -8.93 -0.33 4.39e-18 Total body bone mineral density; BRCA cis rs12530845 0.943 rs60858457 chr7:135336918 T/C cg23117316 chr7:135346802 PL-5283 -0.37 -8.65 -0.32 4.18e-17 Red blood cell traits; BRCA cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.54 -11.25 -0.41 6.77e-27 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4566357 0.787 rs6748048 chr2:227822440 T/C cg11843606 chr2:227700838 RHBDD1 -0.48 -9.88 -0.36 1.67e-21 Coronary artery disease; BRCA cis rs9467773 1.000 rs9467791 chr6:26562486 A/G cg11502198 chr6:26597334 ABT1 -0.5 -9.81 -0.36 2.99e-21 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.804 rs8186428 chr11:48734677 C/T cg00717180 chr2:96193071 NA -0.32 -8.73 -0.33 2.2e-17 HDL cholesterol; BRCA cis rs561341 0.941 rs72825736 chr17:30330286 G/A cg23018236 chr17:30244563 NA -0.63 -10.18 -0.37 1.19e-22 Hip circumference adjusted for BMI; BRCA trans rs60843830 1.000 rs3828165 chr2:220889 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 14.63 0.5 5.12e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs13053817 1.000 rs13054354 chr22:29840180 T/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.5 -9.67 -0.36 9.47e-21 Carotid atherosclerosis in HIV infection; BRCA cis rs10782582 0.593 rs12142247 chr1:76235746 C/T cg03433033 chr1:76189801 ACADM -0.47 -9.43 -0.35 7.58e-20 Daytime sleep phenotypes; BRCA cis rs17253792 0.822 rs10147380 chr14:56054354 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.57 7.98 0.3 6.98e-15 Putamen volume; BRCA trans rs11098499 0.604 rs10022185 chr4:120571765 C/G cg25214090 chr10:38739885 LOC399744 0.52 10.84 0.39 3.14e-25 Corneal astigmatism; BRCA cis rs9814567 0.727 rs4435681 chr3:134344435 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.51 -16.02 -0.54 8.27e-49 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6831352 0.879 rs1230154 chr4:99988659 C/T cg13256891 chr4:100009986 ADH5 0.42 7.86 0.3 1.59e-14 Alcohol dependence; BRCA cis rs7474896 0.537 rs1208591 chr10:38212502 A/T cg25427524 chr10:38739819 LOC399744 -0.48 -8.9 -0.33 5.7e-18 Obesity (extreme); BRCA cis rs73072330 1.000 rs17729010 chr3:47912703 A/G cg04507495 chr3:47563649 NA -1.12 -11.59 -0.42 2.61e-28 Stem cell growth factor beta levels; BRCA trans rs2204008 0.557 rs11520191 chr12:38197057 T/A cg06521331 chr12:34319734 NA -0.5 -9.23 -0.34 4.03e-19 Bladder cancer; BRCA cis rs6964587 1.000 rs12536529 chr7:91684086 C/T cg17063962 chr7:91808500 NA -0.51 -12.06 -0.43 2.48e-30 Breast cancer; BRCA cis rs1595825 0.891 rs77032596 chr2:198603185 T/G cg19156104 chr2:198669113 PLCL1 -0.47 -8.42 -0.32 2.4e-16 Ulcerative colitis; BRCA cis rs11190604 1.000 rs9420797 chr10:102331147 C/T cg07080220 chr10:102295463 HIF1AN 0.55 13.43 0.47 2.14e-36 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9392556 0.829 rs643232 chr6:4122249 C/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.37 -8.01 -0.3 5.46e-15 Blood metabolite levels; BRCA cis rs7267979 1.000 rs6076345 chr20:25381895 T/G cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.71 -0.33 2.57e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg10862848 chr6:42927986 GNMT -0.35 -14.8 -0.51 8.08e-43 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs6479891 1.000 rs10995543 chr10:65239547 T/C cg14819942 chr15:35414228 NA 0.35 8.51 0.32 1.23e-16 Arthritis (juvenile idiopathic); BRCA cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs950776 0.642 rs12905641 chr15:78964362 A/G cg06917634 chr15:78832804 PSMA4 -0.43 -8.38 -0.31 3.37e-16 Sudden cardiac arrest; BRCA trans rs79976124 0.879 rs10944856 chr6:66636960 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.61 10.88 0.4 2.09e-25 Type 2 diabetes; BRCA cis rs2652834 1.000 rs2729785 chr15:63402574 G/A cg05507819 chr15:63340323 TPM1 0.45 8.32 0.31 5.39e-16 HDL cholesterol; BRCA cis rs826838 1.000 rs1095575 chr12:39110284 C/G cg13010199 chr12:38710504 ALG10B -0.43 -10.06 -0.37 3.3e-22 Heart rate; BRCA cis rs9814567 1.000 rs6772896 chr3:134203347 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.37 -0.31 3.76e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4818225 0.895 rs2183588 chr21:42626882 A/G cg21268422 chr21:42620091 BACE2 0.41 7.82 0.3 2.13e-14 Educational attainment; BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg22920501 chr2:26401640 FAM59B -0.67 -11.53 -0.42 4.47e-28 Gut microbiome composition (summer); BRCA cis rs2985684 0.894 rs4900932 chr14:50022928 A/G cg04989706 chr14:50066350 PPIL5 -0.5 -10.02 -0.37 4.88e-22 Carotid intima media thickness; BRCA cis rs801193 1.000 rs2707836 chr7:66160435 A/C cg18876405 chr7:65276391 NA 0.62 15.35 0.52 1.6e-45 Aortic root size; BRCA cis rs1997103 1.000 rs6593237 chr7:55411015 T/C cg17469321 chr7:55412551 NA 0.5 9.64 0.36 1.28e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA trans rs561341 1.000 rs72823785 chr17:30273784 C/T cg27661571 chr11:113659931 NA -0.76 -11.59 -0.42 2.46e-28 Hip circumference adjusted for BMI; BRCA cis rs1874326 0.545 rs6964218 chr7:138112861 A/G cg18008034 chr7:138118925 NA -0.4 -8.42 -0.32 2.52e-16 Quantitative traits; BRCA cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg09359103 chr1:154839909 KCNN3 -0.55 -14.53 -0.5 1.55e-41 Prostate cancer; BRCA cis rs72781680 1.000 rs72796359 chr2:24160545 T/C cg20701182 chr2:24300061 SF3B14 0.67 9.81 0.36 2.93e-21 Lymphocyte counts; BRCA cis rs4555082 0.834 rs28846738 chr14:105745781 A/G cg06808227 chr14:105710500 BRF1 -0.82 -16.21 -0.54 9.87e-50 Mean platelet volume;Platelet distribution width; BRCA cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg20607798 chr8:58055168 NA 0.48 8.4 0.32 3e-16 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg12311346 chr5:56204834 C5orf35 -0.61 -12.96 -0.46 2.87e-34 Initial pursuit acceleration; BRCA cis rs514406 0.505 rs374849 chr1:53185631 G/A cg16325326 chr1:53192061 ZYG11B 0.93 25.5 0.71 1.89e-99 Monocyte count; BRCA cis rs9811920 0.799 rs9832134 chr3:99836722 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.54 12.19 0.43 6.71e-31 Axial length; BRCA cis rs9399135 0.967 rs6910530 chr6:135332770 C/T cg24558204 chr6:135376177 HBS1L 0.49 13.18 0.46 2.92e-35 Red blood cell count; BRCA cis rs35146811 0.844 rs13232115 chr7:99670932 T/C cg13334819 chr7:99746414 C7orf59 -0.41 -9.57 -0.35 2.24e-20 Coronary artery disease; BRCA cis rs2072499 0.966 rs2253677 chr1:156171296 C/G cg06970220 chr1:156163860 SLC25A44 -0.39 -9.46 -0.35 5.61e-20 Testicular germ cell tumor; BRCA cis rs5758511 0.680 rs5758698 chr22:42684818 C/T cg00645731 chr22:42541494 CYP2D7P1 0.5 9.26 0.34 3.02e-19 Birth weight; BRCA cis rs7945718 0.934 rs4553350 chr11:12759834 A/G cg25843174 chr11:12811716 TEAD1 -0.24 -9.17 -0.34 6.24e-19 Educational attainment (years of education); BRCA cis rs1552244 1.000 rs66797209 chr3:10078526 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs895636 0.898 rs10205310 chr2:45188646 A/G cg16198908 chr2:45192207 NA 0.5 9.53 0.35 3.12e-20 Metabolite levels;Fasting plasma glucose; BRCA cis rs6121246 0.559 rs6058465 chr20:30397691 G/A cg21427119 chr20:30132790 HM13 -0.35 -7.95 -0.3 8.21e-15 Mean corpuscular hemoglobin; BRCA cis rs919433 0.680 rs7590010 chr2:198400668 C/T cg00792783 chr2:198669748 PLCL1 0.36 8.38 0.31 3.45e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.51 0.55 2.91e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg23285459 chr7:2802560 GNA12 -0.38 -9.51 -0.35 3.81e-20 Height; BRCA cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs919433 0.680 rs1961558 chr2:198487278 C/T cg00792783 chr2:198669748 PLCL1 0.35 8.02 0.3 4.99e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs950169 0.580 rs17598114 chr15:85171317 C/T cg12863693 chr15:85201151 NMB 0.56 12.03 0.43 3.39e-30 Schizophrenia; BRCA cis rs826838 0.904 rs7973992 chr12:39168233 T/C cg26384229 chr12:38710491 ALG10B 0.81 20.34 0.63 2.82e-71 Heart rate; BRCA cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg16339924 chr4:17578868 LAP3 0.66 15.57 0.52 1.33e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10911232 0.507 rs7547953 chr1:183031641 T/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.25e-51 Hypertriglyceridemia; BRCA cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg16482183 chr6:26056742 HIST1H1C 0.53 11.4 0.41 1.5e-27 Height; BRCA cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg22972055 chr7:872293 UNC84A 0.39 8.64 0.32 4.49e-17 Cerebrospinal P-tau181p levels; BRCA cis rs6456156 0.565 rs12529238 chr6:167465576 G/A cg07741184 chr6:167504864 NA 0.33 9.82 0.36 2.83e-21 Primary biliary cholangitis; BRCA cis rs12586317 0.620 rs76293361 chr14:35570889 G/A cg16230307 chr14:35515116 FAM177A1 0.69 14.26 0.49 3.01e-40 Psoriasis; BRCA cis rs7927771 0.524 rs10838782 chr11:47877800 A/G cg20307385 chr11:47447363 PSMC3 0.41 9.27 0.34 2.75e-19 Subjective well-being; BRCA cis rs9815354 0.812 rs17280952 chr3:41810834 T/C cg03022575 chr3:42003672 ULK4 0.7 9.61 0.36 1.66e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg09263875 chr16:632152 PIGQ 0.73 21.2 0.64 6.33e-76 Height; BRCA cis rs6840360 0.571 rs4696098 chr4:152489053 C/T cg22705602 chr4:152727874 NA -0.32 -7.84 -0.3 1.88e-14 Intelligence (multi-trait analysis); BRCA cis rs243505 0.528 rs1558419 chr7:148480233 C/T cg09806900 chr7:148480153 CUL1 0.47 9.93 0.37 1.02e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg11189052 chr15:85197271 WDR73 -0.34 -8.2 -0.31 1.27e-15 P wave terminal force; BRCA cis rs4746818 1.000 rs7091695 chr10:70964997 A/G cg11621586 chr10:70884670 VPS26A -0.75 -13.26 -0.46 1.21e-35 Left atrial antero-posterior diameter; BRCA trans rs7647973 0.593 rs55997059 chr3:49858661 A/T cg21665057 chr3:196295764 WDR53;FBXO45 0.42 8.95 0.33 3.72e-18 Menarche (age at onset); BRCA cis rs868036 1.000 rs4633663 chr15:68106378 G/C cg08079166 chr15:68083412 MAP2K5 0.35 9.46 0.35 5.8e-20 Restless legs syndrome; BRCA trans rs9325144 0.624 rs12231544 chr12:38901956 C/T cg23762105 chr12:34175262 ALG10 0.36 8.47 0.32 1.73e-16 Morning vs. evening chronotype; BRCA cis rs7580658 0.963 rs2090574 chr2:128131391 C/A cg09760422 chr2:128146352 NA -0.35 -7.84 -0.3 1.83e-14 Protein C levels; BRCA cis rs1008375 0.932 rs6814465 chr4:17659034 C/T cg16339924 chr4:17578868 LAP3 0.67 16.2 0.54 1.04e-49 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2072499 0.966 rs1137703 chr1:156184458 T/C cg25208724 chr1:156163844 SLC25A44 1.03 33.1 0.79 1.05e-140 Testicular germ cell tumor; BRCA cis rs1008375 0.931 rs6449326 chr4:17699790 G/T cg16339924 chr4:17578868 LAP3 0.57 13.86 0.48 2.16e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10267417 0.603 rs7789051 chr7:19956618 A/T cg05791153 chr7:19748676 TWISTNB 0.42 7.86 0.3 1.65e-14 Night sleep phenotypes; BRCA cis rs2637030 0.533 rs2607511 chr5:52930471 G/A cg06476337 chr5:52856530 NDUFS4 0.38 8.82 0.33 1.09e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.3 -0.38 3.93e-23 Initial pursuit acceleration; BRCA cis rs6831352 0.918 rs1042364 chr4:100045574 T/C cg12011299 chr4:100065546 ADH4 0.5 11.61 0.42 2.12e-28 Alcohol dependence; BRCA cis rs6456156 0.586 rs7742305 chr6:167485723 C/T cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.53 11.06 0.4 4.01e-26 Personality dimensions; BRCA cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg14558114 chr2:88469736 THNSL2 0.59 8.36 0.31 3.96e-16 Plasma clusterin levels; BRCA cis rs11785693 0.862 rs11780705 chr8:4988221 G/A cg26367366 chr8:4980734 NA 0.7 12.0 0.43 4.41e-30 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs7336332 0.527 rs1475219 chr13:28037415 A/G cg22138327 chr13:27999177 GTF3A 0.43 8.57 0.32 7.6e-17 Weight; BRCA cis rs8180040 0.654 rs6773521 chr3:47234419 A/G cg27129171 chr3:47204927 SETD2 -0.71 -17.4 -0.57 8.85e-56 Colorectal cancer; BRCA cis rs7254114 0.686 rs7249565 chr19:11302807 C/T cg02815516 chr19:11306319 KANK2 -0.35 -10.51 -0.38 5.87e-24 Immature fraction of reticulocytes; BRCA cis rs6484504 0.532 rs1929019 chr11:31267030 C/T cg14844989 chr11:31128820 NA -0.44 -9.46 -0.35 5.96e-20 Red blood cell count; BRCA cis rs1371614 0.566 rs11887401 chr2:27181112 G/T cg00617064 chr2:27272375 NA -0.3 -8.04 -0.3 4.24e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6426558 0.559 rs7549520 chr1:227258858 G/C cg10327440 chr1:227177885 CDC42BPA 0.48 9.44 0.35 6.67e-20 Neutrophil percentage of white cells; BRCA cis rs4363385 0.818 rs1591736 chr1:152987497 A/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.74 -0.33 2.1e-17 Inflammatory skin disease; BRCA cis rs11190604 0.731 rs10883480 chr10:102163821 G/T cg07080220 chr10:102295463 HIF1AN -0.47 -10.52 -0.38 5.66e-24 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6942756 0.955 rs55638303 chr7:128885770 C/T cg02491457 chr7:128862824 NA -0.71 -13.69 -0.48 1.4e-37 White matter hyperintensity burden; BRCA cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg14440974 chr22:39074834 NA -0.38 -9.02 -0.34 2.24e-18 Menopause (age at onset); BRCA cis rs35110281 0.591 rs162390 chr21:44936826 C/T cg01579765 chr21:45077557 HSF2BP -0.38 -9.88 -0.36 1.67e-21 Mean corpuscular volume; BRCA cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg19717773 chr7:2847554 GNA12 -0.43 -9.71 -0.36 6.85e-21 Height; BRCA cis rs2836974 0.831 rs2836964 chr21:40631006 T/C cg11644478 chr21:40555479 PSMG1 0.84 19.22 0.61 2.53e-65 Cognitive function; BRCA cis rs12478296 1.000 rs59036157 chr2:243040228 C/A cg18898632 chr2:242989856 NA -0.5 -8.31 -0.31 5.75e-16 Obesity-related traits; BRCA cis rs7824557 0.767 rs11250127 chr8:11170209 G/A cg21775007 chr8:11205619 TDH 0.61 11.92 0.43 1.02e-29 Retinal vascular caliber; BRCA cis rs16867335 0.652 rs1528439 chr2:181462035 C/T cg23363182 chr2:181467187 NA -0.44 -9.12 -0.34 9.52e-19 Survival in rectal cancer; BRCA cis rs12971120 0.891 rs2278158 chr18:72178300 G/T cg26446133 chr18:72167187 CNDP2 -0.74 -12.91 -0.45 4.65e-34 Refractive error; BRCA cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 26.42 0.72 1.58e-104 Chronic sinus infection; BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg26314531 chr2:26401878 FAM59B 0.91 16.27 0.54 4.67e-50 Gut microbiome composition (summer); BRCA cis rs9788721 0.836 rs17483686 chr15:78733390 A/T cg18825076 chr15:78729989 IREB2 -0.39 -8.27 -0.31 7.67e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs72781680 0.848 rs55725028 chr2:23966447 A/G cg20701182 chr2:24300061 SF3B14 0.66 9.39 0.35 1.01e-19 Lymphocyte counts; BRCA cis rs7666738 0.819 rs13139560 chr4:99081188 C/T cg17366294 chr4:99064904 C4orf37 0.42 8.34 0.31 4.7e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs6840360 0.571 rs62327277 chr4:152555905 C/T cg22705602 chr4:152727874 NA -0.33 -8.2 -0.31 1.29e-15 Intelligence (multi-trait analysis); BRCA cis rs6952808 1.000 rs6977733 chr7:1886725 A/T cg13880726 chr7:1868755 MAD1L1 -0.52 -9.73 -0.36 6.02e-21 Bipolar disorder and schizophrenia; BRCA cis rs11105298 0.891 rs12369685 chr12:89928905 A/G cg00757033 chr12:89920650 WDR51B 0.51 10.0 0.37 5.63e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs16854884 0.526 rs7643341 chr3:143726980 C/T cg06585982 chr3:143692056 C3orf58 0.51 10.21 0.37 8.73e-23 Economic and political preferences (feminism/equality); BRCA trans rs10506458 0.915 rs2013050 chr12:63394310 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -20.32 -0.63 3.25e-71 Hemostatic factors and hematological phenotypes; BRCA cis rs2425143 0.558 rs7274724 chr20:34539466 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -8.3 -0.31 6.41e-16 Blood protein levels; BRCA trans rs75804782 0.521 rs55657931 chr2:239422072 A/G cg01134436 chr17:81009848 B3GNTL1 0.59 8.29 0.31 6.5e-16 Morning vs. evening chronotype;Chronotype; BRCA cis rs757110 0.803 rs7928810 chr11:17372443 G/T cg04705435 chr11:17411270 KCNJ11 0.43 9.37 0.35 1.22e-19 Type 2 diabetes; BRCA cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg18876405 chr7:65276391 NA -0.58 -13.8 -0.48 3.98e-38 Aortic root size; BRCA cis rs9640161 0.750 rs59211922 chr7:150023790 T/G cg12556325 chr7:150026731 C7orf29;LRRC61 -0.54 -13.69 -0.48 1.38e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs2832191 0.740 rs2832168 chr21:30463695 G/A cg24692254 chr21:30365293 RNF160 0.79 22.34 0.66 3.96e-82 Dental caries; BRCA cis rs3820928 0.874 rs13430941 chr2:227904447 G/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.32 -0.31 5.39e-16 Pulmonary function; BRCA cis rs941873 0.835 rs4246944 chr10:81105684 C/T cg11057378 chr10:81107060 PPIF 0.36 9.09 0.34 1.23e-18 Height; BRCA trans rs6076960 0.684 rs6054058 chr20:6262187 T/C cg21095983 chr6:86352623 SYNCRIP 0.43 9.65 0.36 1.12e-20 Smooth-surface caries; BRCA cis rs10464366 0.560 rs12701692 chr7:39135551 A/G cg18850127 chr7:39170497 POU6F2 0.43 9.46 0.35 5.57e-20 IgG glycosylation; BRCA trans rs9858542 1.000 rs9822268 chr3:49719729 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.98 -0.37 7.01e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs2204008 0.777 rs6582664 chr12:37947022 A/G cg06521331 chr12:34319734 NA 0.45 8.88 0.33 6.77e-18 Bladder cancer; BRCA cis rs2276314 0.857 rs62101394 chr18:33592299 C/T cg19628046 chr18:33552617 C18orf21 0.54 10.88 0.4 2e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7666738 0.546 rs13149516 chr4:98913030 T/A cg05340658 chr4:99064831 C4orf37 0.56 11.14 0.4 1.86e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs17270561 0.636 rs6456697 chr6:25741434 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs875971 0.862 rs1083554 chr7:65852341 T/C cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg17143192 chr8:8559678 CLDN23 0.57 11.1 0.4 2.73e-26 Obesity-related traits; BRCA trans rs11098499 0.954 rs1022145 chr4:120230979 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.74 0.42 5.97e-29 Corneal astigmatism; BRCA cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg14844989 chr11:31128820 NA 0.46 9.59 0.35 1.95e-20 Red blood cell count; BRCA trans rs208520 0.802 rs208499 chr6:66932146 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.82 -15.24 -0.52 5.55e-45 Exhaled nitric oxide output; BRCA trans rs1997103 1.000 rs6973337 chr7:55411534 T/C cg20935933 chr6:143382018 AIG1 0.61 11.7 0.42 8.67e-29 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg05623727 chr3:50126028 RBM5 -0.41 -9.76 -0.36 4.49e-21 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg14004847 chr7:1930337 MAD1L1 -0.44 -8.96 -0.33 3.43e-18 Bipolar disorder and schizophrenia; BRCA cis rs7553864 0.835 rs4415539 chr1:87604245 C/T cg17420885 chr1:87600446 LOC339524 0.38 8.2 0.31 1.34e-15 Smoking behavior; BRCA cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.12 0.4 2.15e-26 Bipolar disorder; BRCA cis rs3845702 1.000 rs3845697 chr2:180798553 C/T cg01881094 chr2:180872142 CWC22 0.68 13.26 0.46 1.29e-35 Schizophrenia; BRCA trans rs3857536 0.813 rs9354404 chr6:66948408 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.86 -12.83 -0.45 1.14e-33 Platelet count; BRCA cis rs1003719 0.788 rs2835600 chr21:38468958 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs875971 1.000 rs7789768 chr7:65938980 A/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs2404602 0.716 rs8039545 chr15:76707247 A/G cg23625390 chr15:77176239 SCAPER 0.38 8.98 0.33 3.06e-18 Blood metabolite levels; BRCA cis rs4566357 0.595 rs6707286 chr2:227911400 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -9.48 -0.35 4.75e-20 Coronary artery disease; BRCA cis rs12612619 0.689 rs11681145 chr2:27290525 A/G cg00617064 chr2:27272375 NA -0.32 -7.97 -0.3 7.18e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg11752832 chr7:134001865 SLC35B4 0.52 13.53 0.47 7.69e-37 Mean platelet volume; BRCA cis rs6820391 0.748 rs7675771 chr4:54447002 G/C cg04173182 chr4:54446035 LNX1 0.53 11.9 0.43 1.27e-29 Cervical artery dissection; BRCA cis rs77972916 0.505 rs11899984 chr2:43578246 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.64 -10.89 -0.4 1.81e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs2204008 0.837 rs11495548 chr12:38076756 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 2.99e-22 Bladder cancer; BRCA cis rs11025559 0.812 rs10833338 chr11:20514709 A/G cg19653624 chr11:20408972 PRMT3 -0.43 -10.0 -0.37 5.61e-22 Pursuit maintenance gain; BRCA cis rs2576037 0.796 rs2571031 chr18:44577063 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.39 8.02 0.3 5.09e-15 Personality dimensions; BRCA cis rs7412746 0.658 rs3768016 chr1:150809919 T/C cg18016565 chr1:150552671 MCL1 0.34 7.91 0.3 1.1e-14 Melanoma; BRCA cis rs595982 0.559 rs17272680 chr19:49364511 A/G cg21252483 chr19:49399788 TULP2 0.39 9.14 0.34 7.94e-19 Red cell distribution width; BRCA cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg13319975 chr6:146136371 FBXO30 0.41 9.35 0.35 1.47e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4242434 0.927 rs7843828 chr8:22463623 C/T cg03733263 chr8:22462867 KIAA1967 1.03 24.63 0.7 1.03e-94 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs1008375 0.932 rs4235390 chr4:17696378 G/T cg16339924 chr4:17578868 LAP3 0.57 13.96 0.48 7.72e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg11812906 chr14:75593930 NEK9 -0.69 -16.07 -0.54 4.66e-49 Height; BRCA cis rs1008375 1.000 rs2058338 chr4:17678600 A/G cg15017067 chr4:17643749 FAM184B -0.31 -9.36 -0.35 1.39e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9291683 0.588 rs3756238 chr4:10013202 C/T cg26043149 chr18:55253948 FECH 0.39 8.34 0.31 4.61e-16 Bone mineral density; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg18279126 chr7:2041391 MAD1L1 -0.39 -8.88 -0.33 6.47e-18 Bipolar disorder and schizophrenia; BRCA cis rs6076065 0.630 rs2424559 chr20:23430519 A/G cg11657817 chr20:23433608 CST11 0.43 10.23 0.38 7.57e-23 Facial morphology (factor 15, philtrum width); BRCA trans rs3960554 0.808 rs3779419 chr7:75695081 G/A cg19862616 chr7:65841803 NCRNA00174 0.57 12.2 0.43 6.59e-31 Eotaxin levels; BRCA cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg18016565 chr1:150552671 MCL1 0.34 7.83 0.3 2.01e-14 Melanoma; BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs10242455 0.702 rs17161700 chr7:98977067 A/G cg18809830 chr7:99032528 PTCD1 -0.62 -8.21 -0.31 1.23e-15 Blood metabolite levels; BRCA cis rs7095944 0.614 rs10901818 chr10:126449428 G/A cg08799069 chr10:126477246 METTL10 -0.4 -10.09 -0.37 2.69e-22 Asthma; BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg03709012 chr19:19516395 GATAD2A 0.81 19.13 0.6 7.84e-65 Tonsillectomy; BRCA cis rs752010 0.695 rs10890155 chr1:42107843 C/T cg06885757 chr1:42089581 HIVEP3 0.22 8.17 0.31 1.64e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs68170813 0.559 rs7798223 chr7:106829223 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.35 -0.31 4.12e-16 Coronary artery disease; BRCA cis rs7772486 0.790 rs6570724 chr6:146151283 T/C cg13319975 chr6:146136371 FBXO30 -0.34 -8.03 -0.3 4.84e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9815354 0.597 rs60690674 chr3:41997811 G/C cg03022575 chr3:42003672 ULK4 0.65 9.34 0.35 1.53e-19 Pulse pressure;Diastolic blood pressure; BRCA cis rs17376456 1.000 rs59472588 chr5:93511981 A/G cg25358565 chr5:93447407 FAM172A 1.13 18.07 0.58 2.97e-59 Diabetic retinopathy; BRCA cis rs17376456 0.569 rs10057664 chr5:93182274 C/T cg25358565 chr5:93447407 FAM172A -0.66 -11.16 -0.4 1.51e-26 Diabetic retinopathy; BRCA cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg18964960 chr10:1102726 WDR37 -0.52 -8.99 -0.33 2.86e-18 Response to angiotensin II receptor blocker therapy; BRCA cis rs477895 0.713 rs67546972 chr11:63962162 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.69 0.45 4.39e-33 Mean platelet volume; BRCA cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg20701182 chr2:24300061 SF3B14 0.7 13.41 0.47 2.62e-36 Lymphocyte counts; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.3 -0.44 2.27e-31 Alzheimer's disease; BRCA cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg01448562 chr3:133502909 NA -0.61 -14.5 -0.5 2.21e-41 Iron status biomarkers; BRCA cis rs858239 0.571 rs6953020 chr7:23172132 T/C cg23682824 chr7:23144976 KLHL7 0.42 10.87 0.39 2.35e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs9914988 0.832 rs34267753 chr17:27157586 T/C cg20469991 chr17:27169893 C17orf63 -0.45 -8.8 -0.33 1.25e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg13628971 chr7:2884303 GNA12 0.45 10.19 0.37 1.07e-22 Height; BRCA cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg06108461 chr20:60628389 TAF4 -0.8 -17.52 -0.57 2.09e-56 Body mass index; BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.44 -0.32 2.17e-16 Total body bone mineral density; BRCA cis rs919433 0.617 rs2037590 chr2:198584775 T/A cg00792783 chr2:198669748 PLCL1 -0.44 -9.73 -0.36 5.68e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6909752 0.611 rs7770180 chr6:22565043 T/C cg13666174 chr6:22585274 NA -0.35 -7.94 -0.3 8.84e-15 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease);Coronary artery disease; BRCA cis rs7903847 0.642 rs2297668 chr10:99160046 C/T cg20016023 chr10:99160130 RRP12 -0.26 -8.35 -0.31 4.4e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg12165864 chr7:66369176 NA -0.41 -9.51 -0.35 3.94e-20 Corneal structure; BRCA cis rs11792861 0.926 rs1333344 chr9:111776224 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.35 0.31 4.18e-16 Menarche (age at onset); BRCA cis rs514406 0.565 rs897732 chr1:53382816 A/C cg24675658 chr1:53192096 ZYG11B -0.66 -14.82 -0.51 6.35e-43 Monocyte count; BRCA trans rs2270927 0.510 rs6876070 chr5:75579237 T/A cg13563193 chr19:33072644 PDCD5 0.88 10.26 0.38 5.98e-23 Mean corpuscular volume; BRCA cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg24692254 chr21:30365293 RNF160 -0.64 -16.62 -0.55 7.79e-52 Dental caries; BRCA cis rs2032447 0.641 rs442601 chr6:25934524 G/A cg12310025 chr6:25882481 NA -0.54 -12.34 -0.44 1.54e-31 Intelligence (multi-trait analysis); BRCA cis rs1568889 1.000 rs12802157 chr11:28060285 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.71 0.5 2.14e-42 Bipolar disorder; BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg09877947 chr5:131593287 PDLIM4 0.44 9.97 0.37 7.34e-22 Acylcarnitine levels; BRCA trans rs8002861 0.619 rs9562516 chr13:44431738 T/C cg17145862 chr1:211918768 LPGAT1 0.47 10.51 0.38 6.23e-24 Leprosy; BRCA cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.57 8.41 0.32 2.78e-16 Cerebrospinal P-tau181p levels; BRCA cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.14 -0.34 8.44e-19 Menopause (age at onset); BRCA cis rs7246967 0.673 rs7245540 chr19:22881504 C/G cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA trans rs7824557 0.843 rs2736375 chr8:11115749 C/T cg06636001 chr8:8085503 FLJ10661 -0.53 -10.47 -0.38 8.43e-24 Retinal vascular caliber; BRCA cis rs1865760 0.534 rs1541988 chr6:25950804 C/A cg12310025 chr6:25882481 NA -0.39 -9.08 -0.34 1.3e-18 Height; BRCA cis rs6565180 0.963 rs4787642 chr16:30359408 T/C cg17640201 chr16:30407289 ZNF48 -0.7 -15.86 -0.53 5.17e-48 Tonsillectomy; BRCA cis rs7666738 0.830 rs13149346 chr4:99009933 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs17345786 0.906 rs72940399 chr3:101122575 A/T cg12386194 chr3:101231763 SENP7 0.66 12.93 0.46 3.92e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs2303759 0.918 rs2288480 chr19:49867016 C/G cg22307029 chr19:49891270 CCDC155 0.62 11.31 0.41 3.82e-27 Multiple sclerosis; BRCA cis rs889312 0.500 rs702691 chr5:56114526 T/G cg24531977 chr5:56204891 C5orf35 -0.41 -8.31 -0.31 5.85e-16 Breast cancer;Breast cancer (early onset); BRCA cis rs9914988 0.943 rs67327562 chr17:27108828 G/A cg20469991 chr17:27169893 C17orf63 -0.44 -8.77 -0.33 1.57e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs765787 0.530 rs12909987 chr15:45512207 C/T cg24006582 chr15:45444508 DUOX1 -0.51 -10.65 -0.39 1.69e-24 Uric acid levels; BRCA cis rs3806843 0.966 rs7737424 chr5:140146345 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.51 -0.35 3.8e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6964587 0.900 rs4279 chr7:91764128 C/A cg01689657 chr7:91764605 CYP51A1 0.24 8.79 0.33 1.34e-17 Breast cancer; BRCA cis rs477692 0.673 rs556253 chr10:131355781 G/A cg24747557 chr10:131355152 MGMT -0.37 -8.99 -0.33 2.89e-18 Response to temozolomide; BRCA cis rs7666738 0.830 rs35531558 chr4:98938217 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs16976116 0.901 rs28489312 chr15:55494048 A/C cg11288833 chr15:55489084 RSL24D1 0.48 10.67 0.39 1.49e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs769267 0.930 rs4808967 chr19:19640524 A/G cg03709012 chr19:19516395 GATAD2A 0.78 18.25 0.59 3.43e-60 Tonsillectomy; BRCA cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg17063962 chr7:91808500 NA 0.53 12.23 0.44 4.94e-31 Breast cancer; BRCA cis rs6547741 0.935 rs6749426 chr2:27847606 T/C cg27432699 chr2:27873401 GPN1 0.41 8.84 0.33 9.46e-18 Oral cavity cancer; BRCA cis rs12586317 0.534 rs28384418 chr14:35452126 C/A cg05294307 chr14:35346193 BAZ1A -0.59 -11.64 -0.42 1.57e-28 Psoriasis; BRCA cis rs2230307 0.656 rs7531066 chr1:100463804 A/G cg24955406 chr1:100503596 HIAT1 0.54 9.42 0.35 8.29e-20 Carotid intima media thickness; BRCA cis rs9811920 0.965 rs6767441 chr3:99863183 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 12.56 0.44 1.72e-32 Axial length; BRCA cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.2 0.73 7.83e-109 Chronic sinus infection; BRCA cis rs1891275 0.515 rs7475294 chr10:93508199 T/C cg07889827 chr10:93443413 NA -0.4 -10.96 -0.4 9.54e-26 Intelligence (multi-trait analysis); BRCA cis rs12760731 0.565 rs11583503 chr1:178169663 G/C cg00404053 chr1:178313656 RASAL2 0.64 7.83 0.3 2.09e-14 Obesity-related traits; BRCA cis rs12973672 1.000 rs1052033 chr19:35770471 C/T cg12095397 chr19:35769544 USF2 0.38 8.38 0.31 3.28e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26314531 chr2:26401878 FAM59B -0.66 -11.34 -0.41 2.81e-27 Gut microbiome composition (summer); BRCA cis rs4478858 0.654 rs113490486 chr1:31712863 C/G cg00250761 chr1:31883323 NA -0.31 -8.07 -0.3 3.51e-15 Alcohol dependence; BRCA cis rs5750830 0.546 rs4821891 chr22:39785381 C/T cg05872129 chr22:39784769 NA -0.56 -12.93 -0.46 3.82e-34 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.668 rs2409721 chr8:11038244 A/T cg15556689 chr8:8085844 FLJ10661 -0.38 -9.29 -0.34 2.39e-19 Triglycerides; BRCA cis rs1593 0.734 rs4862670 chr4:187145423 A/T cg09526685 chr4:187126073 CYP4V2 0.91 10.57 0.39 3.65e-24 Activated partial thromboplastin time; BRCA cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.83 -0.3 1.98e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.43 -9.61 -0.36 1.6e-20 Personality dimensions; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.98e-16 Menopause (age at onset); BRCA cis rs4819052 0.851 rs7279182 chr21:46656112 G/A cg11663144 chr21:46675770 NA -0.57 -13.12 -0.46 5.54e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs1973993 0.561 rs3851275 chr1:96990823 G/A cg10631902 chr5:14652156 NA -0.41 -10.11 -0.37 2.16e-22 Weight; BRCA trans rs9329221 0.736 rs12548025 chr8:10260921 A/T cg15556689 chr8:8085844 FLJ10661 0.36 8.44 0.32 2.15e-16 Neuroticism; BRCA cis rs6582630 0.537 rs7310749 chr12:38400472 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.5 0.38 6.9e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs13046373 0.535 rs7276743 chr21:31984545 C/T cg22337977 chr21:31811175 KRTAP15-1 0.34 7.82 0.3 2.11e-14 HDL cholesterol; BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg12444411 chr7:2802554 GNA12 -0.38 -9.42 -0.35 7.8e-20 Height; BRCA trans rs9291683 0.588 rs3756237 chr4:10013378 G/A cg26043149 chr18:55253948 FECH 0.39 8.34 0.31 4.61e-16 Bone mineral density; BRCA cis rs9653442 0.712 rs6714788 chr2:100686173 A/G cg22139774 chr2:100720529 AFF3 0.29 8.35 0.31 4.25e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA trans rs7615952 0.512 rs34085484 chr3:125544186 T/C cg07211511 chr3:129823064 LOC729375 -0.78 -15.04 -0.51 5.2e-44 Blood pressure (smoking interaction); BRCA cis rs7927771 1.000 rs12361031 chr11:47783076 G/A cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs3806843 0.771 rs2563334 chr5:140107065 C/G cg11822812 chr5:140052017 DND1 -0.29 -7.84 -0.3 1.91e-14 Depressive symptoms (multi-trait analysis); BRCA trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21582582 chr3:182698605 DCUN1D1 0.37 9.83 0.36 2.51e-21 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.765 rs2838868 chr21:46714641 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.57 -11.51 -0.41 5.53e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg26384229 chr12:38710491 ALG10B 0.69 15.86 0.53 5.25e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs4148883 0.713 rs3828541 chr4:100042262 A/G cg12011299 chr4:100065546 ADH4 0.41 11.61 0.42 2.12e-28 Alcohol dependence; BRCA cis rs7772486 0.875 rs2474356 chr6:146296798 G/A cg23711669 chr6:146136114 FBXO30 0.74 17.03 0.56 6.71e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.933 rs13225884 chr7:148857795 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.87 0.33 7.51e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10504229 0.906 rs17805439 chr8:58172400 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs7786808 0.782 rs7787923 chr7:158227312 A/G cg01191920 chr7:158217561 PTPRN2 -0.37 -9.23 -0.34 3.88e-19 Obesity-related traits; BRCA cis rs7819412 0.875 rs6981523 chr8:11061792 C/T cg21775007 chr8:11205619 TDH -0.45 -9.2 -0.34 5.02e-19 Triglycerides; BRCA cis rs2635047 1.000 rs2635047 chr18:44736336 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.37 7.97 0.3 7.36e-15 Educational attainment; BRCA cis rs7246657 0.598 rs10417545 chr19:37654263 C/G cg18154014 chr19:37997991 ZNF793 0.53 8.87 0.33 7.33e-18 Coronary artery calcification; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs1595825 0.945 rs73058813 chr2:198858268 A/G cg19156104 chr2:198669113 PLCL1 -0.45 -8.28 -0.31 7.34e-16 Ulcerative colitis; BRCA cis rs7246657 0.525 rs10401417 chr19:37467540 C/T cg18154014 chr19:37997991 ZNF793 0.5 8.56 0.32 8.66e-17 Coronary artery calcification; BRCA cis rs6930083 0.527 rs9368950 chr6:36627872 T/C cg08179530 chr6:36648295 CDKN1A -0.53 -11.45 -0.41 1.01e-27 Coronary artery disease; BRCA cis rs11112613 0.713 rs11112590 chr12:105951376 C/G cg03607813 chr12:105948248 NA -0.56 -9.72 -0.36 6.2e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs10493773 1.000 rs55654440 chr1:86176158 G/C cg17807903 chr1:86174739 ZNHIT6 -0.45 -9.31 -0.35 2.1e-19 Urate levels in overweight individuals; BRCA cis rs35146811 0.586 rs1076237 chr7:99585441 A/C cg13334819 chr7:99746414 C7orf59 -0.35 -7.93 -0.3 9.57e-15 Coronary artery disease; BRCA cis rs57221529 0.713 rs12521091 chr5:590710 G/T cg09021430 chr5:549028 NA -0.65 -13.57 -0.47 5.08e-37 Lung disease severity in cystic fibrosis; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs11252926 0.563 rs11252290 chr10:461989 C/T cg16386425 chr10:429943 DIP2C -0.4 -8.53 -0.32 1.1e-16 Psychosis in Alzheimer's disease; BRCA cis rs7727544 0.660 rs2631361 chr5:131707380 C/A cg07395648 chr5:131743802 NA 0.4 9.95 0.37 8.89e-22 Blood metabolite levels; BRCA cis rs12310956 0.532 rs2087270 chr12:33850109 C/T cg06521331 chr12:34319734 NA -0.39 -7.82 -0.3 2.15e-14 Morning vs. evening chronotype; BRCA cis rs9815354 1.000 rs9873207 chr3:41884750 C/T cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs1865760 1.000 rs2071298 chr6:25914901 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.41 0.38 1.49e-23 Height; BRCA cis rs9837602 1.000 rs9837602 chr3:99824685 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.3e-26 Breast cancer; BRCA cis rs2777491 0.915 rs7178777 chr15:41634588 C/A cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.9 -0.48 1.47e-38 Ulcerative colitis; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.63 -13.14 -0.46 4.35e-35 Lymphocyte counts; BRCA cis rs6546550 0.901 rs11902198 chr2:70144596 C/A cg02498382 chr2:70120550 SNRNP27 -0.53 -11.47 -0.41 7.78e-28 Prevalent atrial fibrillation; BRCA cis rs7520050 1.000 rs7540699 chr1:46338585 A/G cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2576037 0.763 rs2060418 chr18:44576535 A/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.39 8.03 0.3 4.8e-15 Personality dimensions; BRCA cis rs17376456 0.877 rs10064520 chr5:93427358 T/C cg25358565 chr5:93447407 FAM172A 1.24 19.5 0.61 8.3e-67 Diabetic retinopathy; BRCA cis rs2011503 0.941 rs55765017 chr19:19368264 G/A cg15839431 chr19:19639596 YJEFN3 -0.39 -8.54 -0.32 1.01e-16 Bipolar disorder; BRCA cis rs8114671 0.562 rs2064454 chr20:33496169 C/T cg07148914 chr20:33460835 GGT7 0.48 10.33 0.38 3e-23 Height; BRCA cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg13854012 chr2:162103682 NA -0.39 -8.72 -0.33 2.4e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs6088580 0.634 rs6059867 chr20:33078103 C/T cg06115741 chr20:33292138 TP53INP2 0.35 7.95 0.3 8.75e-15 Glomerular filtration rate (creatinine); BRCA cis rs7927592 0.913 rs11228262 chr11:68274907 G/T cg20283391 chr11:68216788 NA -0.48 -9.31 -0.35 2.06e-19 Total body bone mineral density; BRCA cis rs250677 1.000 rs40525 chr5:148432932 G/T cg18129178 chr5:148520854 ABLIM3 0.56 11.16 0.4 1.55e-26 Breast cancer; BRCA cis rs2576037 0.501 rs8089938 chr18:44459497 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.46 9.86 0.36 1.98e-21 Personality dimensions; BRCA cis rs9467711 0.559 rs13208916 chr6:26601940 G/A cg12826209 chr6:26865740 GUSBL1 0.61 8.1 0.31 2.75e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6964587 0.967 rs10231350 chr7:91808499 G/T cg01689657 chr7:91764605 CYP51A1 0.23 8.04 0.3 4.22e-15 Breast cancer; BRCA cis rs7833790 0.724 rs12676336 chr8:82771008 C/T cg17211192 chr8:82754475 SNX16 0.54 12.22 0.44 5.41e-31 Diastolic blood pressure; BRCA cis rs10197940 0.624 rs3771901 chr2:152432481 G/A cg06191203 chr2:152266755 RIF1 -0.4 -11.38 -0.41 1.88e-27 Lung cancer; BRCA cis rs2046867 0.818 rs1502757 chr3:72864161 C/T cg25664220 chr3:72788482 NA -0.56 -11.89 -0.43 1.35e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs7385804 0.727 rs221790 chr7:100278282 G/C cg16850897 chr7:100343110 ZAN 0.36 8.1 0.31 2.82e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs9527 0.551 rs28606370 chr10:104670832 C/A cg04362960 chr10:104952993 NT5C2 0.43 10.26 0.38 5.87e-23 Arsenic metabolism; BRCA cis rs3733585 0.673 rs4235348 chr4:9951968 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.36 -0.38 2.35e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9858542 0.953 rs3811699 chr3:49396360 T/C cg03060546 chr3:49711283 APEH -0.51 -10.44 -0.38 1.2e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4853036 0.953 rs3771539 chr2:70033711 G/C cg02498382 chr2:70120550 SNRNP27 -0.41 -8.01 -0.3 5.64e-15 Colorectal or endometrial cancer; BRCA cis rs6460942 1.000 rs2033871 chr7:12405098 C/A cg06484146 chr7:12443880 VWDE -0.62 -8.99 -0.33 2.88e-18 Coronary artery disease; BRCA cis rs12701220 0.655 rs34696066 chr7:1140919 C/T cg26769984 chr7:1090371 C7orf50 0.49 9.09 0.34 1.27e-18 Bronchopulmonary dysplasia; BRCA cis rs8114671 0.836 rs2425006 chr20:33571228 T/G cg07148914 chr20:33460835 GGT7 -0.42 -9.19 -0.34 5.39e-19 Height; BRCA cis rs7599312 0.534 rs7607373 chr2:213409719 G/A cg16329650 chr2:213403929 ERBB4 0.64 17.84 0.58 4.51e-58 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6750047 0.515 rs13417487 chr2:38289162 G/T cg07380506 chr2:38303506 CYP1B1 0.55 12.46 0.44 4.53e-32 Cutaneous malignant melanoma;Melanoma; BRCA trans rs3857536 0.813 rs7770349 chr6:66946659 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA trans rs1493916 0.870 rs1389531 chr18:31386616 C/T cg27147174 chr7:100797783 AP1S1 -0.53 -10.61 -0.39 2.46e-24 Life satisfaction; BRCA cis rs11190604 1.000 rs11190604 chr10:102302457 A/G cg07080220 chr10:102295463 HIF1AN 0.64 14.96 0.51 1.38e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg22875332 chr1:76189707 ACADM 0.68 12.12 0.43 1.34e-30 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs11039798 0.588 rs643668 chr11:48413399 C/G cg15704280 chr7:45808275 SEPT13 -0.48 -8.11 -0.31 2.55e-15 Axial length; BRCA cis rs6594713 0.717 rs10056194 chr5:112857862 T/G cg12552261 chr5:112820674 MCC 0.48 8.38 0.31 3.39e-16 Brain cytoarchitecture; BRCA cis rs1401999 0.668 rs6806313 chr3:183642152 G/C cg01324343 chr3:183735012 ABCC5 0.63 15.35 0.52 1.61e-45 Anterior chamber depth; BRCA cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg04450456 chr4:17643702 FAM184B 0.36 10.38 0.38 2.02e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9287719 0.649 rs6722126 chr2:10721642 A/G cg00105475 chr2:10696890 NA 0.39 8.71 0.33 2.63e-17 Prostate cancer; BRCA cis rs59918340 0.764 rs4961256 chr8:142229946 G/A cg23750338 chr8:142222470 SLC45A4 0.51 12.52 0.44 2.47e-32 Immature fraction of reticulocytes; BRCA cis rs735396 1.000 rs2259816 chr12:121435587 A/C cg02403541 chr12:121454288 C12orf43 -0.54 -10.35 -0.38 2.65e-23 N-glycan levels; BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 16.92 0.56 2.33e-53 Platelet count; BRCA cis rs1018836 0.923 rs6998150 chr8:91645969 A/C cg16814680 chr8:91681699 NA -0.6 -12.67 -0.45 5.74e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.13e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg20307385 chr11:47447363 PSMC3 0.41 8.55 0.32 8.95e-17 Subjective well-being; BRCA cis rs13108904 0.870 rs2291199 chr4:1244267 A/G cg00684032 chr4:1343700 KIAA1530 0.37 8.82 0.33 1.09e-17 Obesity-related traits; BRCA cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg23711669 chr6:146136114 FBXO30 0.79 18.59 0.59 5.62e-62 Lobe attachment (rater-scored or self-reported); BRCA trans rs8073060 0.544 rs225258 chr17:33956883 C/T cg19694781 chr19:47549865 TMEM160 -1.03 -22.16 -0.66 3.86e-81 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9296092 0.538 rs76589475 chr6:33519517 G/C cg13560919 chr6:33536144 NA -0.85 -18.62 -0.59 3.9e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9649213 0.531 rs35216698 chr7:97896175 C/T cg21770322 chr7:97807741 LMTK2 0.44 11.06 0.4 3.85e-26 Prostate cancer (SNP x SNP interaction); BRCA trans rs11039798 0.588 rs61932767 chr11:48704806 C/T cg15704280 chr7:45808275 SEPT13 0.58 9.92 0.37 1.1e-21 Axial length; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg17330251 chr7:94953956 PON1 -0.57 -13.91 -0.48 1.28e-38 Paraoxonase activity; BRCA cis rs7267979 1.000 rs6115146 chr20:25304507 G/A cg08601574 chr20:25228251 PYGB -0.36 -8.6 -0.32 6.12e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs861020 1.000 rs680923 chr1:209986672 T/C cg09163369 chr1:210001066 C1orf107 0.52 9.62 0.36 1.54e-20 Orofacial clefts; BRCA cis rs1003719 0.762 rs3787780 chr21:38462614 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.09 0.49 1.88e-39 Eye color traits; BRCA cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg26149184 chr10:133730230 NA 0.4 8.2 0.31 1.37e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs12517041 1.000 rs28421903 chr5:23281290 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg03433033 chr1:76189801 ACADM 0.76 17.24 0.56 5.59e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7408868 0.563 rs10404382 chr19:15301389 C/A cg14696996 chr19:15285081 NOTCH3 0.8 12.14 0.43 1.21e-30 Pulse pressure; BRCA cis rs6426558 0.537 rs6692080 chr1:227390162 C/T cg10327440 chr1:227177885 CDC42BPA -0.47 -9.14 -0.34 8.04e-19 Neutrophil percentage of white cells; BRCA cis rs1050631 0.536 rs1785928 chr18:33725931 A/G cg19453250 chr18:33710783 SLC39A6;ELP2 0.29 7.87 0.3 1.57e-14 Esophageal squamous cell cancer (length of survival); BRCA cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg07636037 chr3:49044803 WDR6 0.98 28.88 0.75 5.69e-118 Parkinson's disease; BRCA cis rs5758659 0.652 rs133301 chr22:42390093 C/T cg15557168 chr22:42548783 NA -0.32 -8.83 -0.33 9.8e-18 Cognitive function; BRCA cis rs9463078 0.506 rs4714820 chr6:44736737 T/A cg25276700 chr6:44698697 NA 0.35 8.05 0.3 4.19e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4690686 1.000 rs4690686 chr4:177242959 C/T cg17059388 chr4:177262070 NA 0.36 7.94 0.3 9.09e-15 Essential tremor; BRCA cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg17971929 chr21:40555470 PSMG1 -0.49 -10.98 -0.4 8.08e-26 Menarche (age at onset); BRCA cis rs6580649 0.883 rs4760621 chr12:48561262 A/G cg24011408 chr12:48396354 COL2A1 0.44 7.87 0.3 1.47e-14 Lung cancer; BRCA cis rs10791323 0.628 rs2851118 chr11:133705995 A/C cg15485101 chr11:133734466 NA 0.41 9.84 0.36 2.25e-21 Childhood ear infection; BRCA cis rs514406 0.505 rs405208 chr1:53176674 C/T cg24675658 chr1:53192096 ZYG11B -0.66 -14.48 -0.5 2.63e-41 Monocyte count; BRCA cis rs11098499 0.863 rs17050695 chr4:120489527 G/T cg09307838 chr4:120376055 NA 0.64 13.69 0.48 1.3e-37 Corneal astigmatism; BRCA cis rs9653442 0.866 rs12712065 chr2:100761105 C/G cg22139774 chr2:100720529 AFF3 -0.31 -8.54 -0.32 9.94e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs11764590 0.694 rs10235664 chr7:2086814 T/C cg23422044 chr7:1970798 MAD1L1 -0.45 -9.5 -0.35 4.07e-20 Neuroticism; BRCA cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg11890956 chr21:40555474 PSMG1 1.05 29.88 0.76 2.06e-123 Cognitive function; BRCA cis rs68170813 0.559 rs17349904 chr7:106897237 A/C cg02696742 chr7:106810147 HBP1 -0.49 -7.82 -0.3 2.11e-14 Coronary artery disease; BRCA cis rs7394190 0.748 rs60632610 chr10:75415677 C/T cg07699608 chr10:75541558 CHCHD1 0.56 8.73 0.33 2.21e-17 Incident atrial fibrillation; BRCA cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.37 8.0 0.3 5.91e-15 Osteoporosis; BRCA cis rs2404602 0.608 rs17361504 chr15:76601871 A/G cg22467129 chr15:76604101 ETFA -0.54 -12.59 -0.45 1.3e-32 Blood metabolite levels; BRCA cis rs4819052 0.819 rs13046807 chr21:46672286 A/G cg11663144 chr21:46675770 NA -0.6 -14.21 -0.49 5.23e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs2204008 0.837 rs73112346 chr12:38357606 C/T cg06521331 chr12:34319734 NA -0.52 -9.3 -0.35 2.25e-19 Bladder cancer; BRCA cis rs2282802 0.685 rs2337082 chr5:139649201 G/A cg26211634 chr5:139558579 C5orf32 0.35 8.4 0.32 2.78e-16 Intelligence (multi-trait analysis); BRCA cis rs7100689 0.516 rs10887711 chr10:82034842 A/G cg01528321 chr10:82214614 TSPAN14 0.74 15.74 0.53 1.94e-47 Post bronchodilator FEV1; BRCA cis rs11583043 0.958 rs12730160 chr1:101438791 G/A cg00063077 chr1:101360652 SLC30A7;EXTL2 0.4 8.06 0.3 3.78e-15 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs9527 0.830 rs10883790 chr10:104640955 A/C cg04362960 chr10:104952993 NT5C2 0.48 10.54 0.38 4.79e-24 Arsenic metabolism; BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.53 -9.55 -0.35 2.65e-20 Gut microbiome composition (summer); BRCA cis rs10779751 1.000 rs1205592 chr1:11305663 C/T cg08854313 chr1:11322531 MTOR 0.75 15.28 0.52 3.79e-45 Body mass index; BRCA cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg22105103 chr4:187893119 NA 0.41 13.28 0.47 1.05e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg20607798 chr8:58055168 NA -0.53 -8.32 -0.31 5.3e-16 Developmental language disorder (linguistic errors); BRCA cis rs6546550 0.901 rs12613947 chr2:70161342 A/G cg02498382 chr2:70120550 SNRNP27 -0.51 -11.11 -0.4 2.48e-26 Prevalent atrial fibrillation; BRCA cis rs2624839 0.630 rs2624841 chr3:50198415 C/T cg14019146 chr3:50243930 SLC38A3 -0.58 -14.1 -0.49 1.65e-39 Intelligence (multi-trait analysis); BRCA cis rs6088590 0.561 rs6088528 chr20:33156742 G/A cg06115741 chr20:33292138 TP53INP2 0.4 8.82 0.33 1.09e-17 Coronary artery disease; BRCA cis rs1209950 0.866 rs1734587 chr21:40180884 A/G cg01359822 chr21:40176597 ETS2 0.34 8.63 0.32 4.89e-17 Non-small cell lung cancer (survival); BRCA cis rs2239547 0.603 rs6805298 chr3:53096552 A/G cg11645453 chr3:52864694 ITIH4 -0.41 -10.03 -0.37 4.44e-22 Schizophrenia; BRCA cis rs7727544 0.548 rs35696821 chr5:131508017 C/T cg14196790 chr5:131705035 SLC22A5 0.37 9.17 0.34 6.34e-19 Blood metabolite levels; BRCA cis rs2559856 0.935 rs2695287 chr12:102088361 T/C cg12924262 chr12:102091054 CHPT1 0.38 8.57 0.32 7.72e-17 Blood protein levels; BRCA cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.76 -0.42 5.05e-29 Alcohol dependence; BRCA trans rs3733585 0.673 rs4311316 chr4:9955971 A/C cg26043149 chr18:55253948 FECH 0.36 8.08 0.3 3.24e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7552404 0.696 rs10782602 chr1:76464261 T/C cg10523679 chr1:76189770 ACADM 0.62 10.33 0.38 2.97e-23 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.871 rs60342323 chr8:58154899 T/C cg22535103 chr8:58192502 C8orf71 -0.51 -10.84 -0.39 3.07e-25 Developmental language disorder (linguistic errors); BRCA cis rs78456975 0.622 rs11888851 chr2:1518254 C/G cg01028140 chr2:1542097 TPO -0.61 -12.38 -0.44 1e-31 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs116979167 0.575 rs1728649 chr7:105170570 A/G cg19920283 chr7:105172520 RINT1 0.46 9.47 0.35 5.26e-20 Bipolar disorder (body mass index interaction); BRCA cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg11657440 chr19:46296263 DMWD -0.54 -12.65 -0.45 6.93e-33 Coronary artery disease; BRCA trans rs3960554 0.741 rs10232162 chr7:75702505 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 12.55 0.44 1.93e-32 Eotaxin levels; BRCA cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg01475377 chr6:109611718 NA -0.52 -13.16 -0.46 3.54e-35 Reticulocyte fraction of red cells; BRCA cis rs3806843 0.801 rs2531358 chr5:140117437 A/G cg21161173 chr5:140098174 VTRNA1-2 0.31 7.86 0.3 1.68e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs300703 0.542 rs415660 chr2:189972 C/T cg21211680 chr2:198530 NA 0.39 8.55 0.32 9.36e-17 Blood protein levels; BRCA cis rs10876993 0.890 rs1092472 chr12:58036688 G/T cg18357645 chr12:58087776 OS9 0.43 11.97 0.43 6.07e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs9814567 1.000 rs4535272 chr3:134299916 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.42 0.61 2.15e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7829975 0.742 rs1533059 chr8:8684953 A/G cg08975724 chr8:8085496 FLJ10661 -0.44 -9.61 -0.36 1.62e-20 Mood instability; BRCA cis rs7666738 0.830 rs13116691 chr4:98929771 A/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs17384381 1.000 rs12758237 chr1:85870783 G/A cg16011679 chr1:85725395 C1orf52 0.53 8.2 0.31 1.32e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9462027 0.628 rs9469886 chr6:34758824 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.94 -0.3 9.2e-15 Systemic lupus erythematosus; BRCA cis rs9811920 0.609 rs793460 chr3:99615733 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs1868673 1.000 rs6810143 chr3:150174510 A/T cg04908077 chr3:150187338 NA 0.31 8.4 0.32 2.96e-16 Waist circumference; BRCA cis rs597539 0.652 rs1249474 chr11:68654774 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 17.64 0.57 4.66e-57 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs2882667 0.898 rs11950819 chr5:138397100 T/C cg04439458 chr5:138467593 SIL1 -0.33 -8.85 -0.33 8.3e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs208515 0.525 rs10944868 chr6:66687508 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 14.53 0.5 1.58e-41 Exhaled nitric oxide levels; BRCA cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg20503657 chr10:835505 NA 0.83 15.21 0.52 7.74e-45 Eosinophil percentage of granulocytes; BRCA cis rs1008375 1.000 rs7659718 chr4:17638020 A/C cg15017067 chr4:17643749 FAM184B 0.31 9.7 0.36 7.64e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9297145 0.565 rs7794690 chr7:98764768 G/A cg05967295 chr7:98741636 SMURF1 -0.61 -13.72 -0.48 9.61e-38 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs798554 0.680 rs1713912 chr7:2895784 C/A cg14863265 chr7:2801509 GNA12 -0.42 -9.82 -0.36 2.73e-21 Height; BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.36 0.61 4.72e-66 Platelet count; BRCA cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.09 -0.3 2.98e-15 Bipolar disorder; BRCA cis rs7246657 0.943 rs4803460 chr19:37885228 T/C cg14683738 chr19:37701593 ZNF585B 0.45 8.07 0.3 3.37e-15 Coronary artery calcification; BRCA cis rs9291683 0.588 rs6844329 chr4:10018544 T/C cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.6e-52 Bone mineral density; BRCA cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11051970 0.636 rs325421 chr12:32571595 C/T cg02745156 chr12:32552066 NA 0.25 8.18 0.31 1.52e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg22376730 chr1:1715039 NA 0.32 8.35 0.31 4.19e-16 Body mass index; BRCA cis rs12579753 0.879 rs11115002 chr12:82153090 C/T cg07988820 chr12:82153109 PPFIA2 -0.68 -11.35 -0.41 2.49e-27 Resting heart rate; BRCA cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg15017067 chr4:17643749 FAM184B 0.32 9.8 0.36 3.34e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2404602 0.647 rs7165053 chr15:76978918 A/G cg23625390 chr15:77176239 SCAPER -0.56 -14.51 -0.5 1.85e-41 Blood metabolite levels; BRCA cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.28 0.31 7.1e-16 Aortic root size; BRCA cis rs72781680 1.000 rs72781680 chr2:24238928 C/T cg08917208 chr2:24149416 ATAD2B 1.06 14.75 0.5 1.39e-42 Lymphocyte counts; BRCA cis rs3916 0.955 rs35771722 chr12:121154000 A/G cg21892295 chr12:121157589 UNC119B -0.38 -9.77 -0.36 4.18e-21 Urinary metabolites (H-NMR features); BRCA cis rs9393692 0.902 rs6456711 chr6:26302572 A/C cg05868516 chr6:26286170 HIST1H4H 0.42 8.65 0.32 4.09e-17 Educational attainment; BRCA cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg24562669 chr7:97807699 LMTK2 0.43 11.7 0.42 8.48e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs9549260 0.753 rs1986649 chr13:41178824 C/T cg21288729 chr13:41239152 FOXO1 0.54 8.73 0.33 2.22e-17 Red blood cell count; BRCA cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg12386194 chr3:101231763 SENP7 0.65 12.83 0.45 1.03e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.668 rs6587717 chr1:152984443 G/C cg25856811 chr1:152973957 SPRR3 -0.34 -9.14 -0.34 8.11e-19 Inflammatory skin disease; BRCA cis rs2404602 0.735 rs2468130 chr15:76796496 T/C cg23625390 chr15:77176239 SCAPER -0.48 -11.49 -0.41 6.71e-28 Blood metabolite levels; BRCA cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg25319279 chr11:5960081 NA -0.41 -8.58 -0.32 6.98e-17 DNA methylation (variation); BRCA cis rs911119 1.000 rs734801 chr20:23612791 A/G cg16589663 chr20:23618590 CST3 0.46 8.77 0.33 1.58e-17 Chronic kidney disease; BRCA cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg11301795 chr4:187892539 NA -0.28 -9.48 -0.35 4.83e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089584 0.888 rs6089623 chr20:60615759 A/G cg13770153 chr20:60521292 NA -0.42 -9.24 -0.34 3.52e-19 Body mass index; BRCA cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs7766436 0.767 rs62391062 chr6:22598736 G/A cg13666174 chr6:22585274 NA -0.33 -7.96 -0.3 7.84e-15 Coronary artery disease; BRCA cis rs7402982 0.934 rs8027457 chr15:99204101 A/G cg03437748 chr15:99193247 IGF1R 0.71 17.97 0.58 9.79e-59 Birth weight; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg04025307 chr7:1156635 C7orf50 0.53 13.48 0.47 1.21e-36 Longevity;Endometriosis; BRCA trans rs6479901 0.557 rs7920768 chr10:65060514 C/T cg14819942 chr15:35414228 NA -0.35 -8.58 -0.32 7.23e-17 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs13111977 chr4:98953813 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs12458462 0.859 rs2242177 chr18:77477379 G/A cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.47 -8.8 -0.33 1.27e-17 Monocyte count; BRCA cis rs7647973 1.000 rs8897 chr3:49460407 A/G cg07636037 chr3:49044803 WDR6 0.7 15.39 0.52 1.06e-45 Menarche (age at onset); BRCA cis rs7178424 1.000 rs12592402 chr15:62349020 A/G cg00456672 chr15:62358751 C2CD4A -0.35 -8.01 -0.3 5.27e-15 Height; BRCA cis rs17741873 0.779 rs3812634 chr10:75594486 C/T cg07699608 chr10:75541558 CHCHD1 0.5 8.19 0.31 1.38e-15 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs2425143 1.000 rs2295356 chr20:34252856 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.8 -0.33 1.31e-17 Blood protein levels; BRCA cis rs2191566 0.576 rs431509 chr19:44496070 A/G cg20607764 chr19:44506953 ZNF230 0.4 8.48 0.32 1.61e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs6121246 0.512 rs6060941 chr20:30367383 C/T cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg10295955 chr4:187884368 NA -0.97 -28.18 -0.74 3.44e-114 Lobe attachment (rater-scored or self-reported); BRCA cis rs11792861 0.564 rs3816237 chr9:111718348 T/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 13.13 0.46 5.05e-35 Menarche (age at onset); BRCA cis rs1595825 0.891 rs60582020 chr2:198520555 A/C cg19156104 chr2:198669113 PLCL1 -0.42 -8.19 -0.31 1.47e-15 Ulcerative colitis; BRCA cis rs9527 0.571 rs7096249 chr10:104618524 G/A cg04362960 chr10:104952993 NT5C2 0.42 10.04 0.37 4.07e-22 Arsenic metabolism; BRCA cis rs7666738 0.761 rs13136913 chr4:98998031 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.39 8.1 0.31 2.78e-15 Alzheimer's disease (late onset); BRCA cis rs889312 0.500 rs832570 chr5:56156408 G/A cg24531977 chr5:56204891 C5orf35 -0.4 -8.45 -0.32 1.99e-16 Breast cancer;Breast cancer (early onset); BRCA cis rs1505368 0.532 rs2888093 chr2:213328348 G/A cg16329650 chr2:213403929 ERBB4 0.41 9.71 0.36 6.9299999999999992e-21 Symmetrical dimethylarginine levels; BRCA cis rs7666738 0.546 rs62320963 chr4:98839297 A/G cg05340658 chr4:99064831 C4orf37 0.56 10.77 0.39 5.98e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs34101026 chr21:46662200 C/T cg06618935 chr21:46677482 NA -0.36 -7.98 -0.3 6.64e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1371614 0.523 rs2891534 chr2:27184446 A/G cg00617064 chr2:27272375 NA -0.34 -8.74 -0.33 2.02e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4363385 0.693 rs821755 chr1:153036245 G/C cg24667326 chr1:152973720 SPRR3 -0.31 -8.11 -0.31 2.53e-15 Inflammatory skin disease; BRCA cis rs4808199 0.689 rs12979148 chr19:19406869 T/C cg03709012 chr19:19516395 GATAD2A 0.86 13.07 0.46 9.57e-35 Nonalcoholic fatty liver disease; BRCA cis rs1707322 1.000 rs4660331 chr1:46458783 A/C cg03146154 chr1:46216737 IPP 0.45 9.94 0.37 9.83e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7819412 0.875 rs11250121 chr8:11060311 A/C cg21775007 chr8:11205619 TDH -0.45 -9.01 -0.34 2.39e-18 Triglycerides; BRCA cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg17971929 chr21:40555470 PSMG1 0.73 16.33 0.54 2.45e-50 Cognitive function; BRCA cis rs2204008 0.619 rs8189576 chr12:38307275 G/A cg26384229 chr12:38710491 ALG10B -0.44 -10.15 -0.37 1.49e-22 Bladder cancer; BRCA trans rs5756813 0.754 rs11089854 chr22:38148882 G/A cg19894588 chr14:64061835 NA -0.49 -10.37 -0.38 2.15e-23 Optic cup area;Vertical cup-disc ratio; BRCA cis rs2625529 0.652 rs11634608 chr15:72255718 A/G cg16672083 chr15:72433130 SENP8 0.68 16.14 0.54 2.12e-49 Red blood cell count; BRCA cis rs1153858 0.943 rs8038342 chr15:45651537 T/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.64 0.42 1.55e-28 Homoarginine levels; BRCA cis rs6831352 0.801 rs2602897 chr4:100046293 A/T cg13256891 chr4:100009986 ADH5 0.52 9.75 0.36 4.74e-21 Alcohol dependence; BRCA cis rs7592578 0.771 rs4258824 chr2:191395027 C/T cg11845111 chr2:191398756 TMEM194B -0.78 -15.07 -0.51 3.93e-44 Diastolic blood pressure; BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg20203395 chr5:56204925 C5orf35 -0.52 -10.32 -0.38 3.23e-23 Initial pursuit acceleration; BRCA trans rs1459104 1.000 rs56359124 chr11:55135075 A/G cg15704280 chr7:45808275 SEPT13 0.64 8.0 0.3 5.74e-15 Body mass index; BRCA cis rs4363385 0.720 rs1415967 chr1:152965585 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.53 -0.35 3.29e-20 Inflammatory skin disease; BRCA cis rs7577696 0.512 rs212736 chr2:32473126 T/C cg02381751 chr2:32503542 YIPF4 0.44 8.15 0.31 1.86e-15 Inflammatory biomarkers; BRCA cis rs9733 0.596 rs72702536 chr1:150662574 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.82 0.3 2.18e-14 Tonsillectomy; BRCA cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg10802521 chr3:52805072 NEK4 -0.35 -9.51 -0.35 3.8e-20 Bipolar disorder; BRCA cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg11645453 chr3:52864694 ITIH4 -0.47 -11.21 -0.41 9.86e-27 Schizophrenia; BRCA cis rs208520 0.690 rs12213575 chr6:66735989 A/G cg07460842 chr6:66804631 NA 0.99 19.84 0.62 1.25e-68 Exhaled nitric oxide output; BRCA cis rs6546886 0.912 rs13021880 chr2:74310787 C/G cg14702570 chr2:74259524 NA -0.31 -7.92 -0.3 1.03e-14 Dialysis-related mortality; BRCA cis rs7412746 0.658 rs6657388 chr1:150748786 A/G cg15448220 chr1:150897856 SETDB1 0.36 8.13 0.31 2.26e-15 Melanoma; BRCA cis rs7666738 0.830 rs6532719 chr4:99043691 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.63 0.55 7.2e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs12291225 0.639 rs61883858 chr11:14294708 C/T cg19336497 chr11:14380999 RRAS2 -0.48 -12.05 -0.43 2.72e-30 Sense of smell; BRCA cis rs12477438 0.765 rs2309520 chr2:99570477 C/G cg08885076 chr2:99613938 TSGA10 0.53 12.0 0.43 4.42e-30 Chronic sinus infection; BRCA cis rs877529 0.967 rs139407 chr22:39552075 G/A cg12193277 chr22:39547181 CBX7 0.46 12.55 0.44 1.97e-32 Multiple myeloma; BRCA cis rs7072216 0.763 rs3814140 chr10:100170762 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs6062302 0.522 rs2872810 chr20:62241931 C/T cg03425785 chr20:62221387 GMEB2 -0.51 -8.33 -0.31 5.08e-16 Glioblastoma; BRCA cis rs11098499 0.954 rs3733519 chr4:120423448 A/G cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.65e-45 Corneal astigmatism; BRCA cis rs16958440 0.867 rs80106524 chr18:44676639 G/A cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs9311474 0.713 rs181274 chr3:52233861 T/A cg18404041 chr3:52824283 ITIH1 -0.28 -8.0 -0.3 5.83e-15 Electroencephalogram traits; BRCA cis rs3806933 0.522 rs12522383 chr5:110455266 C/T cg04022379 chr5:110408740 TSLP 0.4 8.85 0.33 8.84e-18 Eosinophilic esophagitis; BRCA cis rs9287719 0.556 rs10168351 chr2:10736810 T/C cg00105475 chr2:10696890 NA 0.48 10.55 0.39 4.24e-24 Prostate cancer; BRCA cis rs7301016 0.846 rs11174569 chr12:63021161 A/C cg11441379 chr12:63026424 NA 0.49 8.95 0.33 3.85e-18 IgG glycosylation; BRCA cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg01262667 chr19:19385393 TM6SF2 -0.4 -10.26 -0.38 5.68e-23 Tonsillectomy; BRCA cis rs2576037 0.901 rs2060416 chr18:44576240 G/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.45 -10.02 -0.37 4.75e-22 Personality dimensions; BRCA trans rs2204008 0.774 rs11495520 chr12:38060605 T/G cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 7.99e-21 Bladder cancer; BRCA cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -9.44 -0.35 6.86e-20 Personality dimensions; BRCA cis rs9649465 1.000 rs3807635 chr7:123382152 A/C cg04330084 chr7:123175371 IQUB -0.33 -8.89 -0.33 6.08e-18 Migraine; BRCA cis rs6724607 1.000 rs4853513 chr2:191479455 C/T cg10560079 chr2:191398806 TMEM194B -0.37 -8.31 -0.31 5.73e-16 Pulse pressure; BRCA cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg03526776 chr6:41159608 TREML2 -0.42 -8.78 -0.33 1.55e-17 Alzheimer's disease (late onset); BRCA cis rs8044868 0.586 rs12917999 chr16:72089451 T/C cg16558253 chr16:72132732 DHX38 -0.45 -10.74 -0.39 7.26e-25 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs600806 0.821 rs1030522 chr1:109900707 C/G cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.4e-15 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs10008392 chr4:120318839 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.93 0.3 9.47e-15 Corneal astigmatism; BRCA cis rs2070488 1.000 rs1002676 chr3:38444932 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.69 -18.85 -0.6 2.28e-63 Electrocardiographic conduction measures; BRCA trans rs6952808 1.000 rs6977733 chr7:1886725 A/T cg04565464 chr8:145669602 NFKBIL2 -0.38 -8.23 -0.31 1.05e-15 Bipolar disorder and schizophrenia; BRCA cis rs2011503 1.000 rs756999 chr19:19448200 A/G cg11584989 chr19:19387371 SF4 -0.59 -13.38 -0.47 3.44e-36 Bipolar disorder; BRCA cis rs9457247 0.663 rs2282861 chr6:167440128 C/T cg07741184 chr6:167504864 NA 0.27 8.1 0.31 2.78e-15 Crohn's disease; BRCA cis rs3008870 1.000 rs2815370 chr1:67503727 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.98 -20.81 -0.64 7.65e-74 Lymphocyte percentage of white cells; BRCA cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg12573674 chr2:1569213 NA -0.5 -8.99 -0.34 2.74e-18 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6060960 0.537 rs6087787 chr20:30452089 G/A cg13852791 chr20:30311386 BCL2L1 0.6 8.07 0.3 3.53e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg08975724 chr8:8085496 FLJ10661 0.43 9.78 0.36 3.78e-21 Mood instability; BRCA cis rs6860806 0.507 rs272872 chr5:131675864 C/T cg12564285 chr5:131593104 PDLIM4 -0.34 -8.04 -0.3 4.43e-15 Breast cancer; BRCA cis rs7918232 1.000 rs6482595 chr10:27380261 A/G cg14442939 chr10:27389572 ANKRD26 -0.68 -12.86 -0.45 7.8e-34 Breast cancer; BRCA cis rs6484504 0.576 rs169623 chr11:31184157 T/C cg06552810 chr11:31128660 NA -0.38 -8.5 -0.32 1.36e-16 Red blood cell count; BRCA cis rs2797160 1.000 rs1739349 chr6:126014984 G/C cg05901451 chr6:126070800 HEY2 0.4 9.62 0.36 1.48e-20 Endometrial cancer; BRCA cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg01884057 chr2:25150051 NA 0.32 8.01 0.3 5.3e-15 Body mass index; BRCA cis rs172166 0.694 rs203876 chr6:28046673 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.18 0.31 1.56e-15 Cardiac Troponin-T levels; BRCA cis rs796364 0.906 rs1658810 chr2:200816382 C/T cg23649088 chr2:200775458 C2orf69 0.58 8.54 0.32 9.56e-17 Schizophrenia; BRCA cis rs1059312 0.808 rs4760533 chr12:129297651 A/G cg21616243 chr12:129299702 MGC16384;SLC15A4 0.78 19.73 0.62 5.08e-68 Systemic lupus erythematosus; BRCA cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.42 -9.52 -0.35 3.47e-20 Personality dimensions; BRCA cis rs2070488 0.775 rs1132064 chr3:38566519 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.73 -0.53 2.29e-47 Electrocardiographic conduction measures; BRCA cis rs35110281 0.805 rs4818843 chr21:45006607 C/T cg04455712 chr21:45112962 RRP1B 0.36 9.36 0.35 1.31e-19 Mean corpuscular volume; BRCA cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg20503657 chr10:835505 NA 0.9 13.79 0.48 4.67e-38 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs10007872 chr4:99001904 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.83 0.3 1.98e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs9325144 0.534 rs1973293 chr12:38679575 C/T cg23762105 chr12:34175262 ALG10 -0.34 -8.57 -0.32 7.76e-17 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.59e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg03351412 chr1:154909251 PMVK 0.61 14.08 0.49 2.12e-39 Prostate cancer; BRCA cis rs6088580 0.634 rs1205336 chr20:32926336 G/A cg24642439 chr20:33292090 TP53INP2 -0.52 -11.19 -0.4 1.1e-26 Glomerular filtration rate (creatinine); BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg03923535 chr7:1197113 ZFAND2A 0.52 11.3 0.41 3.93e-27 Longevity;Endometriosis; BRCA cis rs10504229 1.000 rs67895971 chr8:58177994 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4722585 0.533 rs12334205 chr7:26202490 G/A cg07876897 chr7:26191696 NFE2L3 0.4 8.75 0.33 1.89e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs875971 1.000 rs937495 chr7:65779798 A/G cg11764359 chr7:65958608 NA -0.8 -19.34 -0.61 5.76e-66 Aortic root size; BRCA cis rs35110281 0.627 rs1436291 chr21:44965485 T/C cg21573476 chr21:45109991 RRP1B -0.34 -8.77 -0.33 1.64e-17 Mean corpuscular volume; BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg12000995 chr2:27665139 KRTCAP3 -0.35 -8.92 -0.33 4.84e-18 Total body bone mineral density; BRCA cis rs72772090 0.710 rs10515244 chr5:96078337 C/G cg24982541 chr5:96078678 CAST -0.46 -8.03 -0.3 4.58e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg11663144 chr21:46675770 NA -0.59 -13.52 -0.47 8.14e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg00106254 chr7:1943704 MAD1L1 -0.41 -10.09 -0.37 2.52e-22 Bipolar disorder and schizophrenia; BRCA trans rs11088226 0.645 rs2833904 chr21:33941089 T/C cg09050820 chr6:167586206 TCP10L2 0.76 13.11 0.46 6.28e-35 Gastritis; BRCA trans rs9858213 1 rs9858213 chr3:49731861 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.26 -0.34 3.03e-19 Educational attainment; BRCA cis rs9291683 0.620 rs11722946 chr4:10125990 A/G cg00071950 chr4:10020882 SLC2A9 -0.46 -10.77 -0.39 5.57e-25 Bone mineral density; BRCA cis rs4332037 0.851 rs28728306 chr7:1961814 C/A cg23422044 chr7:1970798 MAD1L1 -0.68 -12.33 -0.44 1.75e-31 Bipolar disorder; BRCA cis rs9399135 0.967 rs12661423 chr6:135349570 C/T cg24558204 chr6:135376177 HBS1L 0.46 12.61 0.45 9.8e-33 Red blood cell count; BRCA cis rs35306767 0.903 rs12778891 chr10:950130 T/A cg20503657 chr10:835505 NA 1.06 18.8 0.6 4.35e-63 Eosinophil percentage of granulocytes; BRCA trans rs208520 0.837 rs208486 chr6:66926255 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.34 -0.54 2.18e-50 Exhaled nitric oxide output; BRCA cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg12927641 chr6:109611667 NA -0.36 -8.87 -0.33 7.54e-18 Reticulocyte fraction of red cells; BRCA cis rs7586879 0.789 rs13398155 chr2:25128550 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.47 0.35 5.47e-20 Body mass index; BRCA cis rs2153535 0.580 rs6921964 chr6:8446395 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.3e-23 Motion sickness; BRCA cis rs7592578 0.766 rs35818159 chr2:191409616 C/G cg10560079 chr2:191398806 TMEM194B -0.75 -12.92 -0.46 4.47e-34 Diastolic blood pressure; BRCA cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg18876405 chr7:65276391 NA -0.51 -11.63 -0.42 1.67e-28 Aortic root size; BRCA cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg01475377 chr6:109611718 NA -0.6 -16.61 -0.55 8.83e-52 Reticulocyte fraction of red cells; BRCA cis rs7395581 0.797 rs10838681 chr11:47275064 C/T cg25783544 chr11:47291846 MADD 0.4 8.61 0.32 5.8e-17 HDL cholesterol; BRCA cis rs9394841 0.667 rs3747749 chr6:41770604 G/A cg08135965 chr6:41755394 TOMM6 0.5 8.13 0.31 2.18e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs1865760 0.892 rs6456705 chr6:25936056 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.83 0.36 2.59e-21 Height; BRCA cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg08213375 chr14:104286397 PPP1R13B 0.66 18.77 0.6 5.93e-63 Schizophrenia; BRCA cis rs17253792 0.822 rs76201070 chr14:56063604 A/C cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs34779708 0.931 rs4934697 chr10:35287192 C/T cg03585969 chr10:35415529 CREM 0.56 11.48 0.41 7.58e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs35306767 0.859 rs11817793 chr10:878895 C/T cg25019033 chr10:957182 NA -0.41 -8.05 -0.3 3.98e-15 Eosinophil percentage of granulocytes; BRCA cis rs113601626 1 rs113601626 chr2:24239189 T/TCCTGGC cg08917208 chr2:24149416 ATAD2B 1.06 14.75 0.5 1.39e-42 Lymphocyte percentage of white cells; BRCA cis rs7666738 0.830 rs11941844 chr4:99042722 A/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11644478 chr21:40555479 PSMG1 0.82 18.31 0.59 1.59e-60 Cognitive function; BRCA cis rs2991971 1.000 rs2993262 chr1:46013733 G/C cg15605315 chr1:45957053 TESK2 0.46 9.38 0.35 1.18e-19 High light scatter reticulocyte count; BRCA trans rs11039798 1.000 rs12223271 chr11:48417420 G/C cg15704280 chr7:45808275 SEPT13 0.55 8.22 0.31 1.18e-15 Axial length; BRCA cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg04553112 chr3:125709451 NA -0.54 -8.12 -0.31 2.34e-15 Blood pressure (smoking interaction); BRCA cis rs13046373 0.508 rs2253516 chr21:31993317 C/T cg16431978 chr21:31797932 KRTAP13-3 0.35 8.83 0.33 9.83e-18 HDL cholesterol; BRCA cis rs3096299 0.582 rs12935119 chr16:89542874 A/T cg00750074 chr16:89608354 SPG7 -0.36 -9.56 -0.35 2.49e-20 Multiple myeloma (IgH translocation); BRCA cis rs1018836 0.651 rs2339175 chr8:91565805 A/T cg16814680 chr8:91681699 NA -0.64 -14.14 -0.49 1.11e-39 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs57221529 0.545 rs55955015 chr5:575182 A/G cg08313168 chr12:7315531 NA 0.5 8.05 0.3 4.19e-15 Lung disease severity in cystic fibrosis; BRCA cis rs1005277 0.579 rs2474572 chr10:38385316 A/G cg00409905 chr10:38381863 ZNF37A -0.57 -12.44 -0.44 5.9e-32 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs4401456 chr4:98959902 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs782590 0.837 rs782585 chr2:55922930 C/T cg18811423 chr2:55921094 PNPT1 0.78 27.65 0.74 2.65e-111 Metabolic syndrome; BRCA cis rs1555322 0.530 rs932562 chr20:33871310 T/C cg03689076 chr20:33865952 NA 0.44 8.01 0.3 5.51e-15 Attention deficit hyperactivity disorder; BRCA cis rs312273 0.806 rs3794248 chr12:41359944 T/G cg17827154 chr12:41323612 CNTN1 -0.41 -10.71 -0.39 9.77e-25 Bipolar disorder; BRCA trans rs877282 0.838 rs34778553 chr10:796865 T/C cg22713356 chr15:30763199 NA 1.42 29.11 0.76 2.94e-119 Uric acid levels; BRCA cis rs9807989 0.507 rs4851572 chr2:103019031 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.49 0.32 1.49e-16 Asthma; BRCA cis rs477895 0.653 rs72918475 chr11:63878644 G/C cg18225595 chr11:63971243 STIP1 0.49 8.4 0.32 2.84e-16 Mean platelet volume; BRCA cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.14 0.4 1.77e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00149659 chr3:10157352 C3orf10 0.73 12.8 0.45 1.46e-33 Alzheimer's disease; BRCA cis rs55794721 0.509 rs11249248 chr1:25753051 T/C cg27572855 chr1:25598939 RHD 0.47 13.35 0.47 4.68e-36 Plateletcrit;Mean corpuscular volume; BRCA trans rs1945213 0.659 rs17149979 chr11:55840862 A/G cg03929089 chr4:120376271 NA 0.6 10.37 0.38 2.13e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs6952808 1.000 rs4601204 chr7:1890925 C/T cg14004847 chr7:1930337 MAD1L1 -0.46 -8.72 -0.33 2.41e-17 Bipolar disorder and schizophrenia; BRCA cis rs7131987 0.650 rs11050187 chr12:29472876 T/C cg09582351 chr12:29534625 ERGIC2 -0.46 -10.53 -0.38 5.29e-24 QT interval; BRCA cis rs1801251 1.000 rs12987513 chr2:233622066 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.23 0.41 7.83e-27 Coronary artery disease; BRCA cis rs4808199 0.947 rs10401193 chr19:19591066 A/G cg03709012 chr19:19516395 GATAD2A 1.07 21.17 0.64 9.29e-76 Nonalcoholic fatty liver disease; BRCA cis rs9858542 0.953 rs3811697 chr3:49590770 C/T cg03060546 chr3:49711283 APEH -0.52 -10.87 -0.39 2.36e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs425277 0.958 rs262660 chr1:2086757 A/G cg24578937 chr1:2090814 PRKCZ 0.57 17.88 0.58 2.83e-58 Height; BRCA cis rs6456156 0.792 rs10946214 chr6:167516122 G/A cg07741184 chr6:167504864 NA 0.31 9.13 0.34 9.05e-19 Primary biliary cholangitis; BRCA cis rs2204008 0.837 rs11180482 chr12:38235950 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.82 0.33 1.11e-17 Bladder cancer; BRCA cis rs273218 1.000 rs156442 chr5:53373029 T/C ch.5.1024479R chr5:53302184 ARL15 0.41 8.53 0.32 1.03e-16 Migraine; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg05552183 chr6:42928497 GNMT 0.71 16.16 0.54 1.74e-49 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg20607798 chr8:58055168 NA 0.55 8.61 0.32 5.84e-17 Developmental language disorder (linguistic errors); BRCA cis rs6772849 0.930 rs4857912 chr3:128329224 G/A cg16766828 chr3:128327626 NA -0.4 -8.93 -0.33 4.5e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs12497850 0.966 rs6792510 chr3:48723302 G/C cg06212747 chr3:49208901 KLHDC8B 0.44 8.94 0.33 4.3e-18 Parkinson's disease; BRCA cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg06046430 chr4:77819534 ANKRD56 0.6 13.44 0.47 1.83e-36 Emphysema distribution in smoking; BRCA cis rs10504229 1.000 rs76944716 chr8:58191643 T/C cg22535103 chr8:58192502 C8orf71 -0.63 -13.52 -0.47 8.57e-37 Developmental language disorder (linguistic errors); BRCA cis rs17253792 0.822 rs28681420 chr14:56088403 G/T cg01858014 chr14:56050164 KTN1 -0.76 -10.26 -0.38 5.65e-23 Putamen volume; BRCA cis rs4766646 0.619 rs4766638 chr12:110298858 T/C cg01252219 chr12:110302105 GLTP 0.36 8.08 0.3 3.16e-15 Metabolite levels (MHPG); BRCA cis rs7666738 0.791 rs6532725 chr4:99061479 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.92 0.4 1.43e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11083475 0.686 rs73040728 chr19:39257601 C/G cg07905965 chr19:39260460 NA 0.48 11.23 0.41 7.5e-27 Heart rate; BRCA trans rs61931739 0.817 rs7963318 chr12:34244929 C/G cg26384229 chr12:38710491 ALG10B -0.44 -10.99 -0.4 7.63e-26 Morning vs. evening chronotype; BRCA cis rs11608355 0.515 rs11609630 chr12:109918934 C/T cg05360138 chr12:110035743 NA 0.74 13.58 0.47 4.43e-37 Neuroticism; BRCA cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg23711669 chr6:146136114 FBXO30 0.71 16.46 0.55 5.02e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 1.000 rs9443645 chr6:79822924 C/T cg05283184 chr6:79620031 NA -0.41 -10.43 -0.38 1.31e-23 Intelligence (multi-trait analysis); BRCA cis rs367615 0.918 rs10067984 chr5:108872684 C/T cg17395555 chr5:108820864 NA 0.37 9.39 0.35 1.03e-19 Colorectal cancer (SNP x SNP interaction); BRCA cis rs9649213 0.593 rs6973775 chr7:98004685 G/A cg24562669 chr7:97807699 LMTK2 0.45 11.93 0.43 9.3e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs1371614 0.523 rs893789 chr2:27183970 C/T cg00617064 chr2:27272375 NA -0.31 -8.24 -0.31 1e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg08564027 chr20:61660810 NA 0.84 22.72 0.67 3.32e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 1.000 rs778706 chr7:65860424 A/G cg11764359 chr7:65958608 NA 0.81 19.65 0.61 1.26e-67 Aortic root size; BRCA cis rs897080 0.515 rs1067346 chr2:44618811 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.0 0.37 5.46e-22 Height; BRCA cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg03060546 chr3:49711283 APEH 0.55 9.22 0.34 4.32e-19 Menarche (age at onset); BRCA cis rs10504229 0.639 rs56066782 chr8:58105857 A/G cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.9e-15 Developmental language disorder (linguistic errors); BRCA cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg12573674 chr2:1569213 NA -0.45 -9.2 -0.34 5.21e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7264396 0.887 rs224364 chr20:34063865 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.33 -0.31 4.97e-16 Total cholesterol levels; BRCA cis rs6088590 0.707 rs67159833 chr20:33488079 T/C cg06115741 chr20:33292138 TP53INP2 0.49 9.84 0.36 2.25e-21 Coronary artery disease; BRCA cis rs9527 0.569 rs78193706 chr10:104780564 T/C cg04362960 chr10:104952993 NT5C2 0.44 9.92 0.37 1.15e-21 Arsenic metabolism; BRCA cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.32 0.41 3.2e-27 Electroencephalogram traits; BRCA cis rs7408868 1.000 rs4809029 chr19:15273248 A/C cg14696996 chr19:15285081 NOTCH3 0.99 14.45 0.5 3.81e-41 Pulse pressure; BRCA cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9733 0.596 rs1415148 chr1:150705755 G/A cg18016565 chr1:150552671 MCL1 0.34 8.03 0.3 4.72e-15 Tonsillectomy; BRCA trans rs9650657 0.585 rs4841401 chr8:10489592 C/G cg06636001 chr8:8085503 FLJ10661 -0.61 -11.56 -0.42 3.45e-28 Neuroticism; BRCA trans rs6582630 0.519 rs11495376 chr12:38284957 A/C cg06521331 chr12:34319734 NA -0.47 -8.83 -0.33 9.63e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.17 -0.34 6.37e-19 Developmental language disorder (linguistic errors); BRCA trans rs637571 0.546 rs11227311 chr11:65585257 C/A cg17712092 chr4:129076599 LARP1B -0.54 -12.54 -0.44 2.19e-32 Eosinophil percentage of white cells; BRCA cis rs11252926 0.625 rs7903876 chr10:482678 T/C cg18196295 chr10:418757 DIP2C -0.37 -8.79 -0.33 1.35e-17 Psychosis in Alzheimer's disease; BRCA cis rs9487051 1.000 rs9487051 chr6:109617079 A/G cg01475377 chr6:109611718 NA -0.51 -12.94 -0.46 3.48e-34 Reticulocyte fraction of red cells; BRCA cis rs589448 0.902 rs528974 chr12:69765918 A/T cg22834771 chr12:69754056 YEATS4 -0.42 -10.58 -0.39 3.25e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg12444411 chr7:2802554 GNA12 -0.38 -9.33 -0.35 1.67e-19 Height; BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg01262667 chr19:19385393 TM6SF2 0.42 10.97 0.4 9.28e-26 Tonsillectomy; BRCA cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.31 0.49 1.77e-40 Motion sickness; BRCA cis rs4930103 0.619 rs10769945 chr11:1985127 C/T cg23202291 chr11:1979235 NA 0.41 9.34 0.35 1.56e-19 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs4481887 0.893 rs4297335 chr1:248473421 C/T cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs9815354 1.000 rs3774372 chr3:41877414 A/G cg03022575 chr3:42003672 ULK4 0.49 7.93 0.3 1e-14 Pulse pressure;Diastolic blood pressure; BRCA cis rs12477438 0.834 rs10179043 chr2:99687490 T/C cg08885076 chr2:99613938 TSGA10 -0.59 -12.91 -0.45 4.64e-34 Chronic sinus infection; BRCA cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.9 14.08 0.49 2.12e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg24829409 chr8:58192753 C8orf71 -0.55 -11.53 -0.41 4.62e-28 Developmental language disorder (linguistic errors); BRCA cis rs7394190 0.748 rs11000771 chr10:75524458 T/G cg07699608 chr10:75541558 CHCHD1 0.61 9.37 0.35 1.19e-19 Incident atrial fibrillation; BRCA cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg26116260 chr4:7069785 GRPEL1 -0.84 -17.21 -0.56 8.24e-55 Monocyte percentage of white cells; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.14 -0.46 4.59e-35 Lymphocyte counts; BRCA trans rs459571 1.000 rs456207 chr9:136911140 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -14.63 -0.5 5.07e-42 Platelet distribution width; BRCA cis rs12477438 0.520 rs1453563 chr2:99720267 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.73 0.71 9.83e-101 Chronic sinus infection; BRCA cis rs7598759 0.588 rs6737291 chr2:232329559 T/C cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.07e-14 Noise-induced hearing loss; BRCA cis rs9341808 0.644 rs76102095 chr6:80942026 G/C cg08355045 chr6:80787529 NA -0.32 -7.85 -0.3 1.72e-14 Sitting height ratio; BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg03709012 chr19:19516395 GATAD2A 0.81 18.91 0.6 1.2e-63 Tonsillectomy; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.61 11.68 0.42 1.03e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9435341 0.965 rs1730862 chr1:107614003 G/A cg09367891 chr1:107599246 PRMT6 -0.55 -10.09 -0.37 2.67e-22 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs2033711 0.870 rs1051500 chr19:58944402 A/G cg26874164 chr19:58962979 ZNF324B 0.44 9.34 0.35 1.61e-19 Uric acid clearance; BRCA cis rs2153535 0.580 rs9379216 chr6:8481235 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1.01e-40 Motion sickness; BRCA cis rs2832191 0.967 rs2251377 chr21:30530599 T/C cg24692254 chr21:30365293 RNF160 0.61 15.44 0.52 6.02e-46 Dental caries; BRCA cis rs875971 0.660 rs6460308 chr7:66084740 T/C cg11764359 chr7:65958608 NA -0.67 -14.98 -0.51 1.07e-43 Aortic root size; BRCA cis rs737008 0.959 rs11865598 chr16:11403432 T/C cg00044050 chr16:11439710 C16orf75 0.38 8.31 0.31 5.86e-16 Obesity-related traits; BRCA cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 30.03 0.77 3.03e-124 Cognitive ability; BRCA cis rs13064411 0.735 rs6778800 chr3:113149236 A/G cg18753928 chr3:113234510 CCDC52 -0.43 -8.51 -0.32 1.2e-16 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2882667 0.537 rs7701116 chr5:138406078 C/T cg04439458 chr5:138467593 SIL1 -0.32 -8.77 -0.33 1.56e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg25036284 chr2:26402008 FAM59B -0.96 -16.14 -0.54 2.09e-49 Gut microbiome composition (summer); BRCA cis rs3784262 0.669 rs12148281 chr15:58311061 C/A cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.27 -0.38 5.18e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg06212747 chr3:49208901 KLHDC8B 0.51 8.0 0.3 5.96e-15 Menarche (age at onset); BRCA cis rs7520050 0.966 rs6677007 chr1:46400590 A/G cg24296786 chr1:45957014 TESK2 0.44 9.87 0.36 1.74e-21 Red blood cell count;Reticulocyte count; BRCA trans rs7746199 0.736 rs34965299 chr6:27521856 A/G cg06606381 chr12:133084897 FBRSL1 -0.84 -8.64 -0.32 4.54e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2839186 0.708 rs17183123 chr21:47671961 G/C cg13012494 chr21:47604986 C21orf56 0.45 9.42 0.35 7.84e-20 Testicular germ cell tumor; BRCA cis rs12541635 0.739 rs1896915 chr8:107083520 G/T cg10147462 chr8:107024639 NA 0.32 8.71 0.33 2.65e-17 Age of smoking initiation; BRCA cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg03264133 chr6:25882463 NA 0.41 8.64 0.32 4.45e-17 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.620 rs2451741 chr6:26629404 A/G cg11502198 chr6:26597334 ABT1 0.56 12.07 0.43 2.29e-30 Intelligence (multi-trait analysis); BRCA cis rs2070488 0.804 rs2268755 chr3:38501916 A/G cg24069376 chr3:38537580 EXOG -0.32 -8.98 -0.33 3.1e-18 Electrocardiographic conduction measures; BRCA cis rs6701037 0.681 rs2285220 chr1:175130773 T/A cg00958927 chr1:175162553 KIAA0040 -0.21 -7.85 -0.3 1.71e-14 Alcohol dependence; BRCA trans rs2018683 0.707 rs2391718 chr7:28974988 T/C cg19402173 chr7:128379420 CALU -0.42 -10.07 -0.37 3.07e-22 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs2153535 0.547 rs9505475 chr6:8542890 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.02 0.48 4.01e-39 Motion sickness; BRCA cis rs17685 0.743 rs10277259 chr7:75802674 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6424115 1.000 rs1018396 chr1:24133612 G/A cg15997130 chr1:24165203 NA 0.49 13.05 0.46 1.11e-34 Immature fraction of reticulocytes; BRCA cis rs7633770 0.786 rs9845998 chr3:46683710 G/A cg11219411 chr3:46661640 NA 0.65 16.96 0.56 1.59e-53 Coronary artery disease; BRCA cis rs1448094 0.512 rs6539926 chr12:86244460 G/A cg19622623 chr12:86230825 RASSF9 -0.33 -9.27 -0.34 2.75e-19 Major depressive disorder; BRCA cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs6665290 0.935 rs17528667 chr1:227201770 C/T cg10327440 chr1:227177885 CDC42BPA -1.14 -45.93 -0.88 1.27e-204 Myeloid white cell count; BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 -1.19 -22.4 -0.66 1.76e-82 Platelet count; BRCA cis rs4076764 0.801 rs6675964 chr1:163375960 A/G cg24596788 chr1:163392923 NA -0.35 -9.29 -0.34 2.37e-19 Motion sickness; BRCA cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg24069376 chr3:38537580 EXOG 0.34 9.37 0.35 1.26e-19 Electrocardiographic conduction measures; BRCA cis rs6088580 0.634 rs4258875 chr20:32924895 C/A cg06115741 chr20:33292138 TP53INP2 -0.38 -8.4 -0.32 2.8e-16 Glomerular filtration rate (creatinine); BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.27 0.56 3.83e-55 Alzheimer's disease; BRCA cis rs220324 0.688 rs2012103 chr21:43561369 A/G cg09727148 chr21:43560719 UMODL1 0.5 8.77 0.33 1.61e-17 Idiopathic osteonecrosis of the femoral head; BRCA cis rs9733 0.596 rs7549795 chr1:150656873 G/A cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs4727027 0.635 rs12111923 chr7:148885877 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.51 9.95 0.37 8.78e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.65 0.32 4.14e-17 Coronary artery disease; BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg08470875 chr2:26401718 FAM59B -0.5 -8.11 -0.31 2.57e-15 Gut microbiome composition (summer); BRCA cis rs36051895 0.603 rs10974972 chr9:5130146 G/A cg02405213 chr9:5042618 JAK2 -0.44 -8.29 -0.31 6.58e-16 Pediatric autoimmune diseases; BRCA cis rs765787 0.530 rs4331289 chr15:45515338 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.33 -0.41 3.01e-27 Uric acid levels; BRCA cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg27129171 chr3:47204927 SETD2 0.73 17.74 0.57 1.4e-57 Colorectal cancer; BRCA cis rs6700896 0.864 rs12030956 chr1:66115298 G/T cg04111102 chr1:66153794 NA 0.34 8.42 0.32 2.57e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs6546550 0.901 rs4852375 chr2:70125988 C/G cg02498382 chr2:70120550 SNRNP27 -0.54 -11.63 -0.42 1.7e-28 Prevalent atrial fibrillation; BRCA cis rs12612619 0.732 rs12613822 chr2:27217102 A/T cg00617064 chr2:27272375 NA -0.33 -8.55 -0.32 9.29e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7618501 0.633 rs2252833 chr3:50004209 C/T cg05623727 chr3:50126028 RBM5 0.46 10.82 0.39 3.77e-25 Intelligence (multi-trait analysis); BRCA cis rs2599510 0.811 rs2583713 chr2:32822729 A/G cg02381751 chr2:32503542 YIPF4 0.42 8.13 0.31 2.17e-15 Interleukin-18 levels; BRCA cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs36051895 0.659 rs10121491 chr9:5046935 T/C cg02405213 chr9:5042618 JAK2 -0.5 -9.5 -0.35 4e-20 Pediatric autoimmune diseases; BRCA cis rs4919694 1.000 rs76255497 chr10:104651955 T/C cg04362960 chr10:104952993 NT5C2 0.9 14.59 0.5 8.3e-42 Arsenic metabolism; BRCA cis rs10883723 0.773 rs11191303 chr10:104255158 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.75 0.62 3.7e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs10499694 0.967 rs11765748 chr7:50615616 T/A cg18232548 chr7:50535776 DDC -0.37 -8.97 -0.33 3.3e-18 Body mass index; BRCA cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg12591125 chr7:1885375 MAD1L1 0.43 8.7 0.33 2.76e-17 Bipolar disorder; BRCA cis rs875971 0.862 rs778697 chr7:65870426 G/A cg18876405 chr7:65276391 NA 0.5 11.2 0.4 1.09e-26 Aortic root size; BRCA cis rs4363385 0.693 rs576941 chr1:153040165 A/G cg25856811 chr1:152973957 SPRR3 0.32 8.25 0.31 9.28e-16 Inflammatory skin disease; BRCA trans rs8002861 0.754 rs4053664 chr13:44429172 A/C cg17145862 chr1:211918768 LPGAT1 0.63 16.18 0.54 1.32e-49 Leprosy; BRCA cis rs7772486 0.790 rs3923579 chr6:146230232 C/G cg23711669 chr6:146136114 FBXO30 -0.77 -17.91 -0.58 1.88e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs941408 1.000 rs1736180 chr19:2796021 C/T cg06609049 chr19:2785107 THOP1 0.57 11.89 0.43 1.39e-29 Total cholesterol levels; BRCA cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs6912958 0.712 rs7746465 chr6:88348996 T/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.52 -0.32 1.15e-16 Monocyte percentage of white cells; BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.59 -0.39 3.03e-24 Gut microbiome composition (summer); BRCA cis rs262150 1.000 rs262154 chr7:158773936 G/A cg19418458 chr7:158789849 NA -0.44 -9.87 -0.36 1.8e-21 Facial morphology (factor 20); BRCA cis rs1499972 0.941 rs56310214 chr3:117640127 G/A cg07612923 chr3:117604196 NA 0.6 8.1 0.31 2.82e-15 Schizophrenia; BRCA cis rs6545883 0.894 rs10496092 chr2:61524679 C/T cg15711740 chr2:61764176 XPO1 0.49 11.81 0.42 2.98e-29 Tuberculosis; BRCA cis rs7666738 0.925 rs2865952 chr4:99040305 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.33 0.31 4.76e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.641 rs2777485 chr6:146334377 G/A cg23711669 chr6:146136114 FBXO30 0.66 13.45 0.47 1.76e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs17270561 0.609 rs4712963 chr6:25740502 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.94 0.33 4.25e-18 Iron status biomarkers; BRCA cis rs6942756 1.000 rs1473236 chr7:128880831 G/T cg02491457 chr7:128862824 NA -0.72 -14.66 -0.5 3.51e-42 White matter hyperintensity burden; BRCA cis rs3806843 0.735 rs2563314 chr5:140047289 A/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.87 0.4 2.18e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs1008375 0.931 rs7435102 chr4:17571480 C/G cg15017067 chr4:17643749 FAM184B 0.34 10.36 0.38 2.37e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg18402987 chr7:1209562 NA 0.55 10.82 0.39 3.77e-25 Longevity;Endometriosis; BRCA cis rs875971 0.505 rs2462573 chr7:65507392 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.43 -9.52 -0.35 3.52e-20 Aortic root size; BRCA cis rs2637266 0.967 rs4979898 chr10:78355672 G/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs6546550 0.867 rs1048266 chr2:70132676 A/G cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.93e-28 Prevalent atrial fibrillation; BRCA cis rs1707322 1.000 rs11211237 chr1:46447329 G/C cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4566357 0.615 rs12328878 chr2:227918962 G/A cg05526886 chr2:227700861 RHBDD1 -0.4 -8.07 -0.3 3.48e-15 Coronary artery disease; BRCA cis rs1967309 0.625 rs730242 chr16:4070433 C/T cg00061520 chr16:4070371 ADCY9 0.34 8.03 0.3 4.58e-15 Response to Dalcetrapib treatment in acute coronary syndrome; BRCA cis rs7246657 0.882 rs8112610 chr19:37928730 C/A cg23950597 chr19:37808831 NA -0.62 -11.46 -0.41 8.48e-28 Coronary artery calcification; BRCA cis rs27434 0.605 rs39840 chr5:96120054 G/C cg16492584 chr5:96139282 ERAP1 -0.4 -8.15 -0.31 1.98e-15 Ankylosing spondylitis; BRCA trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg03929089 chr4:120376271 NA 0.51 7.85 0.3 1.75e-14 Intraocular pressure; BRCA cis rs57221529 0.766 rs72703070 chr5:590458 T/C cg09021430 chr5:549028 NA -0.65 -13.67 -0.48 1.7e-37 Lung disease severity in cystic fibrosis; BRCA cis rs2303759 0.551 rs7249040 chr19:49790602 C/T cg22307029 chr19:49891270 CCDC155 0.52 8.9 0.33 5.86e-18 Multiple sclerosis; BRCA cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg12311346 chr5:56204834 C5orf35 1.01 20.1 0.62 5.35e-70 Initial pursuit acceleration; BRCA cis rs17376456 0.504 rs6898507 chr5:93082343 C/T cg25358565 chr5:93447407 FAM172A 0.7 11.94 0.43 8.08e-30 Diabetic retinopathy; BRCA cis rs1577917 1.000 rs2812972 chr6:86669880 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -11.29 -0.41 4.5e-27 Response to antipsychotic treatment; BRCA cis rs4919694 0.572 rs12261294 chr10:104934952 C/T cg04362960 chr10:104952993 NT5C2 0.71 12.33 0.44 1.66e-31 Arsenic metabolism; BRCA cis rs2625529 0.730 rs12912771 chr15:72162928 A/T cg16672083 chr15:72433130 SENP8 -0.66 -15.52 -0.52 2.61e-46 Red blood cell count; BRCA cis rs7918232 0.567 rs11015463 chr10:27319258 A/G cg14442939 chr10:27389572 ANKRD26 0.46 8.43 0.32 2.38e-16 Breast cancer; BRCA cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg11279151 chr3:101281821 RG9MTD1 -0.39 -8.77 -0.33 1.55e-17 Colorectal cancer; BRCA cis rs1568889 0.838 rs11030229 chr11:28173634 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.53 0.63 2.42e-72 Bipolar disorder; BRCA cis rs4803468 1.000 rs284657 chr19:41929915 G/C cg09537434 chr19:41945824 ATP5SL -1.01 -24.95 -0.7 1.78e-96 Height; BRCA cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.21 -0.31 1.25e-15 Menarche (age at onset); BRCA cis rs2637266 1.000 rs12774835 chr10:78352226 C/G cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs7254114 0.578 rs3745682 chr19:11313256 C/T cg02815516 chr19:11306319 KANK2 -0.35 -9.82 -0.36 2.62e-21 Immature fraction of reticulocytes; BRCA cis rs1707322 0.686 rs2230658 chr1:46078854 A/G cg06784218 chr1:46089804 CCDC17 -0.53 -12.92 -0.46 4.13e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs11731478 chr4:99001686 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1215050 0.755 rs783958 chr4:98893836 A/T cg05340658 chr4:99064831 C4orf37 -0.43 -9.85 -0.36 2.09e-21 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs79976124 0.842 rs7760550 chr6:66628788 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.61 11.36 0.41 2.22e-27 Type 2 diabetes; BRCA cis rs765787 0.530 rs1631533 chr15:45518628 C/T cg15395560 chr15:45543142 SLC28A2 0.29 8.21 0.31 1.22e-15 Uric acid levels; BRCA cis rs7582180 0.629 rs13031906 chr2:100939524 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.97 0.43 6.47e-30 Intelligence (multi-trait analysis); BRCA cis rs6500602 0.701 rs8129 chr16:4562351 A/G cg08645402 chr16:4508243 NA 0.4 9.88 0.36 1.59e-21 Schizophrenia; BRCA cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.73 -0.45 3.01e-33 Chronic sinus infection; BRCA cis rs6540556 0.723 rs11487867 chr1:209892070 G/T cg05527609 chr1:210001259 C1orf107 -0.52 -8.72 -0.33 2.39e-17 Red blood cell count; BRCA trans rs9325144 0.600 rs6582630 chr12:38743508 A/G cg23762105 chr12:34175262 ALG10 0.39 9.59 0.35 1.8899999999999998e-20 Morning vs. evening chronotype; BRCA cis rs780096 0.526 rs1647267 chr2:27651054 A/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs6754311 0.773 rs4988183 chr2:136622046 T/C cg07169764 chr2:136633963 MCM6 0.71 14.6 0.5 7.22e-42 Mosquito bite size; BRCA cis rs6580649 0.941 rs7310579 chr12:48427523 G/A cg05342945 chr12:48394962 COL2A1 0.41 7.95 0.3 8.57e-15 Lung cancer; BRCA trans rs11088226 0.681 rs2833901 chr21:33939318 T/C cg09050820 chr6:167586206 TCP10L2 0.76 13.22 0.46 1.86e-35 Gastritis; BRCA cis rs6060717 0.536 rs6060669 chr20:34480557 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.55 -7.88 -0.3 1.37e-14 Hip circumference adjusted for BMI; BRCA cis rs11758351 0.866 rs75091077 chr6:26207546 A/C cg01420254 chr6:26195488 NA 0.54 8.57 0.32 7.84e-17 Gout;Renal underexcretion gout; BRCA cis rs12579753 0.830 rs12825476 chr12:82238350 G/A cg07988820 chr12:82153109 PPFIA2 -0.64 -10.39 -0.38 1.77e-23 Resting heart rate; BRCA cis rs17818399 0.502 rs1451152 chr2:46800150 C/T cg02822958 chr2:46747628 ATP6V1E2 0.48 9.87 0.36 1.7e-21 Height; BRCA cis rs250677 0.917 rs36066 chr5:148419771 A/G cg18129178 chr5:148520854 ABLIM3 -0.59 -11.71 -0.42 8.16e-29 Breast cancer; BRCA trans rs9784649 1.000 rs1493479 chr5:24987768 A/G cg08600765 chr20:34638493 LOC647979 -0.52 -8.87 -0.33 7.45e-18 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs8072100 0.905 rs8077106 chr17:45653291 T/G cg08085267 chr17:45401833 C17orf57 0.67 14.93 0.51 1.88e-43 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.22e-27 High light scatter reticulocyte count; BRCA cis rs2652822 0.525 rs1910094 chr15:63485527 G/C cg02713581 chr15:63449717 RPS27L 0.42 8.42 0.32 2.53e-16 Metabolic traits; BRCA cis rs57590327 0.503 rs13073613 chr3:81888512 C/A cg07356753 chr3:81810745 GBE1 -0.43 -9.99 -0.37 6.18e-22 Extraversion; BRCA cis rs1862618 0.620 rs189695 chr5:56225769 T/C cg18230493 chr5:56204884 C5orf35 -0.62 -13.37 -0.47 4.03e-36 Initial pursuit acceleration; BRCA cis rs739401 0.572 rs384490 chr11:3078885 A/C cg25174290 chr11:3078921 CARS 0.47 14.62 0.5 5.62e-42 Longevity; BRCA cis rs7172677 1.000 rs8032261 chr15:75424012 A/T cg14664628 chr15:75095509 CSK -0.39 -8.14 -0.31 2.09e-15 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2115630 0.905 rs6496401 chr15:85297793 A/T cg11189052 chr15:85197271 WDR73 -0.35 -8.31 -0.31 5.72e-16 P wave terminal force; BRCA trans rs7824557 0.767 rs1897951 chr8:11169854 C/T cg15556689 chr8:8085844 FLJ10661 0.37 8.72 0.33 2.33e-17 Retinal vascular caliber; BRCA cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.29 0.34 2.48e-19 Rheumatoid arthritis; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.35 -0.31 4.1e-16 Total body bone mineral density; BRCA cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg00071950 chr4:10020882 SLC2A9 0.57 13.99 0.48 5.71e-39 Bone mineral density; BRCA cis rs752010 0.714 rs2182606 chr1:42082375 T/C cg06885757 chr1:42089581 HIVEP3 0.29 10.49 0.38 7.65e-24 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg19628046 chr18:33552617 C18orf21 0.54 10.1 0.37 2.28e-22 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7147624 0.938 rs10467734 chr14:65913947 C/T cg03016385 chr14:66212404 NA -0.57 -8.53 -0.32 1.06e-16 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7618915 0.501 rs10865974 chr3:52718280 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.48 -10.82 -0.39 3.53e-25 Bipolar disorder; BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.67 11.47 0.41 8.17e-28 Renal function-related traits (BUN); BRCA cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg19729930 chr2:74357872 NA 0.59 14.54 0.5 1.44e-41 Gestational age at birth (maternal effect); BRCA cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg03146154 chr1:46216737 IPP -0.49 -10.8 -0.39 4.43e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg22764044 chr5:178986830 RUFY1 0.37 8.56 0.32 8.69e-17 Lung cancer; BRCA cis rs11711311 1.000 rs13073843 chr3:113449150 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg19717773 chr7:2847554 GNA12 -0.43 -9.56 -0.35 2.54e-20 Height; BRCA cis rs7809950 0.530 rs34021916 chr7:106817901 A/G cg23024343 chr7:107201750 COG5 -0.42 -8.6 -0.32 6.12e-17 Coronary artery disease; BRCA cis rs13191362 0.935 rs66923841 chr6:163177317 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.96 14.0 0.48 4.96e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7552404 0.731 rs10873808 chr1:76406767 T/C cg03433033 chr1:76189801 ACADM 0.64 12.33 0.44 1.77e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2320614 0.967 rs11938737 chr4:164045391 G/C cg15586945 chr4:164088095 NAF1 -0.41 -8.16 -0.31 1.72e-15 Lung adenocarcinoma; BRCA trans rs9329221 0.967 rs7005363 chr8:10283748 C/T cg06636001 chr8:8085503 FLJ10661 -0.39 -8.22 -0.31 1.16e-15 Neuroticism; BRCA cis rs208520 1.000 rs12195505 chr6:66986279 T/A cg07460842 chr6:66804631 NA 0.88 14.23 0.49 4.1e-40 Exhaled nitric oxide output; BRCA trans rs1325195 0.507 rs10798652 chr1:179061427 A/G cg11624085 chr17:8464688 MYH10 0.28 8.67 0.32 3.42e-17 IgE grass sensitization; BRCA cis rs2576037 0.623 rs2576042 chr18:44577461 T/C cg19077165 chr18:44547161 KATNAL2 0.58 12.93 0.46 3.86e-34 Personality dimensions; BRCA cis rs6433895 0.710 rs7581267 chr2:182008301 T/C cg00481216 chr2:181971175 NA 0.45 8.2 0.31 1.32e-15 Lymphocyte counts; BRCA cis rs9462027 0.583 rs9462022 chr6:34761684 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA cis rs9814567 0.752 rs7649910 chr3:134241310 A/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.72e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7178424 0.875 rs1436966 chr15:62358682 A/G cg00456672 chr15:62358751 C2CD4A -0.35 -8.59 -0.32 6.75e-17 Height; BRCA cis rs7633770 0.805 rs11130098 chr3:46661926 A/G cg11219411 chr3:46661640 NA -0.7 -20.15 -0.62 2.91e-70 Coronary artery disease; BRCA cis rs6570726 0.577 rs441982 chr6:145842848 A/G cg05347473 chr6:146136440 FBXO30 0.6 11.22 0.41 8.77e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs2066819 1.000 rs79750959 chr12:56702012 C/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs736801 0.504 rs2070721 chr5:131825842 T/G cg02551604 chr5:131831745 NA -0.32 -11.63 -0.42 1.65e-28 Breast cancer;Mosquito bite size; BRCA cis rs61931739 0.517 rs11052964 chr12:34010996 G/C cg06521331 chr12:34319734 NA -0.62 -11.07 -0.4 3.39e-26 Morning vs. evening chronotype; BRCA cis rs3772130 1.000 rs62268732 chr3:121370455 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.4 0.35 9.71e-20 Cognitive performance; BRCA cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg02733842 chr7:1102375 C7orf50 -0.63 -11.54 -0.42 4.23e-28 Bronchopulmonary dysplasia; BRCA cis rs875971 1.000 rs10215948 chr7:65747786 G/A cg12463550 chr7:65579703 CRCP -0.36 -7.83 -0.3 2.06e-14 Aortic root size; BRCA cis rs910316 0.967 rs11624893 chr14:75660124 A/G cg08847533 chr14:75593920 NEK9 -0.8 -19.87 -0.62 9.38e-69 Height; BRCA cis rs10782582 0.632 rs11810154 chr1:76239973 C/G cg10523679 chr1:76189770 ACADM -0.42 -7.93 -0.3 9.99e-15 Daytime sleep phenotypes; BRCA cis rs61990749 0.597 rs2364584 chr14:78152286 T/C cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.17 -0.37 1.27e-22 Fibroblast growth factor basic levels; BRCA trans rs1459104 0.929 rs12794656 chr11:55289878 G/A cg15704280 chr7:45808275 SEPT13 0.64 8.1 0.31 2.84e-15 Body mass index; BRCA trans rs1814175 0.791 rs10769625 chr11:49869887 G/A cg15704280 chr7:45808275 SEPT13 -1.01 -32.47 -0.79 2.47e-137 Height; BRCA cis rs72781680 1.000 rs12616899 chr2:24165235 A/G cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs6879260 1.000 rs10903252 chr5:179733934 T/C cg23221052 chr5:179740743 GFPT2 -0.62 -12.83 -0.45 1.06e-33 Height; BRCA cis rs6973256 0.865 rs2483509 chr7:133341162 G/A cg07491979 chr7:133331646 EXOC4 -0.39 -8.98 -0.33 2.92e-18 Intelligence (multi-trait analysis); BRCA cis rs2304069 0.779 rs245080 chr5:149354805 A/G cg12661370 chr5:149340060 SLC26A2 -0.56 -9.67 -0.36 9.73e-21 HIV-1 control; BRCA trans rs61931739 0.500 rs1843736 chr12:34012080 C/G cg26384229 chr12:38710491 ALG10B 0.67 13.91 0.48 1.34e-38 Morning vs. evening chronotype; BRCA cis rs72781680 0.665 rs2953028 chr2:24068126 T/C cg08917208 chr2:24149416 ATAD2B 0.6 10.29 0.38 4.31e-23 Lymphocyte counts; BRCA cis rs853679 0.546 rs200990 chr6:27815823 T/G cg26587870 chr6:27730563 NA -0.52 -7.98 -0.3 6.65e-15 Depression; BRCA cis rs2204008 0.774 rs11495520 chr12:38060605 T/G cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 2.99e-22 Bladder cancer; BRCA cis rs4808199 0.895 rs4808194 chr19:19435680 T/G cg01262667 chr19:19385393 TM6SF2 0.39 7.95 0.3 8.56e-15 Nonalcoholic fatty liver disease; BRCA cis rs6429082 0.634 rs3856245 chr1:235571428 G/A cg26050004 chr1:235667680 B3GALNT2 -0.53 -12.14 -0.43 1.15e-30 Adiposity; BRCA cis rs9393692 0.645 rs11756673 chr6:26323505 A/G cg00631329 chr6:26305371 NA -0.55 -15.65 -0.53 5.64e-47 Educational attainment; BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg01262667 chr19:19385393 TM6SF2 0.4 10.4 0.38 1.6e-23 Tonsillectomy; BRCA trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg03929089 chr4:120376271 NA 0.66 12.81 0.45 1.29e-33 Height; BRCA cis rs7572733 0.555 rs6729473 chr2:198763928 G/A cg00792783 chr2:198669748 PLCL1 0.48 10.31 0.38 3.72e-23 Dermatomyositis; BRCA cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg15017067 chr4:17643749 FAM184B 0.26 7.81 0.3 2.42e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs12517041 1.000 rs6452110 chr5:23299802 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA trans rs9951602 0.512 rs7240758 chr18:76650677 T/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.01 0.58 5.8e-59 Obesity-related traits; BRCA cis rs2288073 0.965 rs10173173 chr2:24415461 G/T cg06627628 chr2:24431161 ITSN2 0.63 12.23 0.44 4.5e-31 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs2625529 0.590 rs713048 chr15:72543084 G/A cg16672083 chr15:72433130 SENP8 -0.73 -15.64 -0.53 6.2e-47 Red blood cell count; BRCA cis rs7267979 1.000 rs2257991 chr20:25270339 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.34 -9.75 -0.36 4.77e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7586879 0.639 rs7567997 chr2:25096952 A/G cg04586622 chr2:25135609 ADCY3 0.41 10.4 0.38 1.69e-23 Body mass index; BRCA cis rs6748734 0.843 rs6749674 chr2:241834501 G/C cg07537917 chr2:241836409 C2orf54 -0.49 -11.74 -0.42 5.67e-29 Urinary metabolites; BRCA cis rs7633770 0.805 rs11710264 chr3:46661579 T/C cg11219411 chr3:46661640 NA 0.72 21.1 0.64 2.01e-75 Coronary artery disease; BRCA cis rs798554 0.610 rs2527696 chr7:2858315 T/C cg13628971 chr7:2884303 GNA12 0.4 9.12 0.34 9.5e-19 Height; BRCA cis rs1568889 1.000 rs12794100 chr11:28332785 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 13.09 0.46 7.38e-35 Bipolar disorder; BRCA cis rs11227306 0.934 rs7940691 chr11:65640906 C/T cg00576331 chr11:65640516 EFEMP2 0.42 9.35 0.35 1.47e-19 DNA methylation (variation); BRCA cis rs131805 1.000 rs3091397 chr22:50957520 C/T cg05418105 chr22:50981406 NA -0.48 -8.76 -0.33 1.74e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.47 0.38 8.92e-24 Rheumatoid arthritis; BRCA cis rs7246657 0.722 rs4802051 chr19:38072328 C/A cg18154014 chr19:37997991 ZNF793 0.49 9.24 0.34 3.49e-19 Coronary artery calcification; BRCA trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg03929089 chr4:120376271 NA -0.48 -9.1 -0.34 1.18e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs7395581 0.918 rs7120957 chr11:47340649 A/G cg25783544 chr11:47291846 MADD 0.42 9.52 0.35 3.45e-20 HDL cholesterol; BRCA trans rs11098499 0.863 rs2306457 chr4:120472839 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.19 0.31 1.47e-15 Corneal astigmatism; BRCA cis rs4074536 0.574 rs10801971 chr1:116291201 A/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.68 -0.32 3.19e-17 QRS duration; BRCA cis rs473651 0.777 rs550890 chr2:239332555 G/A cg18131467 chr2:239335373 ASB1 0.81 20.97 0.64 1.12e-74 Multiple system atrophy; BRCA trans rs9325144 0.560 rs11182952 chr12:38636278 C/A cg23762105 chr12:34175262 ALG10 0.34 7.92 0.3 1.09e-14 Morning vs. evening chronotype; BRCA cis rs7552404 0.731 rs61770556 chr1:76421902 T/C cg22875332 chr1:76189707 ACADM 0.63 11.05 0.4 4.2e-26 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs9858542 0.953 rs6803222 chr3:49665976 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.97 -0.37 7.34e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs35306767 0.953 rs12259338 chr10:969377 C/T cg25019033 chr10:957182 NA -0.42 -8.8 -0.33 1.27e-17 Eosinophil percentage of granulocytes; BRCA cis rs6460942 1.000 rs7796485 chr7:12405676 G/A cg20607287 chr7:12443886 VWDE -0.56 -7.89 -0.3 1.3e-14 Coronary artery disease; BRCA cis rs1401999 1.000 rs1402002 chr3:183642794 A/G cg01324343 chr3:183735012 ABCC5 0.82 20.45 0.63 7.08e-72 Anterior chamber depth; BRCA cis rs7086627 0.515 rs4933390 chr10:82213081 A/C cg00277334 chr10:82204260 NA -0.84 -24.27 -0.69 1.06e-92 Post bronchodilator FEV1; BRCA cis rs1048238 0.506 rs848195 chr1:16286522 A/G cg21385522 chr1:16154831 NA -0.48 -10.08 -0.37 2.74e-22 Systolic blood pressure; BRCA cis rs7833790 0.636 rs12544174 chr8:82731477 G/A cg27398817 chr8:82754497 SNX16 -0.35 -8.05 -0.3 4.1e-15 Diastolic blood pressure; BRCA cis rs12540874 0.698 rs3823674 chr7:50571996 C/T cg18232548 chr7:50535776 DDC -0.52 -13.28 -0.47 1e-35 Systemic sclerosis; BRCA cis rs2019137 0.560 rs10175462 chr2:113988492 G/A cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.67 14.3 0.49 1.81e-40 Lymphocyte counts; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg08470875 chr2:26401718 FAM59B 0.76 12.06 0.43 2.68e-30 Gut microbiome composition (summer); BRCA cis rs798554 0.686 rs2644298 chr7:2858448 G/C cg09658497 chr7:2847517 GNA12 -0.41 -8.62 -0.32 5.23e-17 Height; BRCA cis rs2836974 0.897 rs13047678 chr21:40708853 C/T cg17971929 chr21:40555470 PSMG1 0.75 15.58 0.52 1.22e-46 Cognitive function; BRCA cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg16325326 chr1:53192061 ZYG11B 0.69 17.45 0.57 4.78e-56 Monocyte count; BRCA cis rs2625529 0.689 rs12898728 chr15:72112853 C/T cg16672083 chr15:72433130 SENP8 -0.64 -15.0 -0.51 8.31e-44 Red blood cell count; BRCA cis rs6665290 0.836 rs56029302 chr1:227203390 G/A cg10327440 chr1:227177885 CDC42BPA -1.09 -40.2 -0.85 4.12e-177 Myeloid white cell count; BRCA cis rs2992756 0.663 rs12750779 chr1:18805048 G/A cg14356550 chr1:18808102 KLHDC7A -0.39 -7.95 -0.3 8.77e-15 Breast cancer; BRCA cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg11644478 chr21:40555479 PSMG1 -0.54 -11.54 -0.42 3.91e-28 Menarche (age at onset); BRCA cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg24642439 chr20:33292090 TP53INP2 0.73 16.56 0.55 1.59e-51 Coronary artery disease; BRCA cis rs68170813 0.599 rs12532849 chr7:106959226 A/C cg02696742 chr7:106810147 HBP1 -0.53 -8.64 -0.32 4.37e-17 Coronary artery disease; BRCA cis rs637571 0.522 rs28578718 chr11:65748400 C/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 13.98 0.48 5.88e-39 Eosinophil percentage of white cells; BRCA trans rs35110281 0.782 rs9981790 chr21:45045052 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.41 0.32 2.73e-16 Mean corpuscular volume; BRCA cis rs7617773 0.743 rs71323397 chr3:48374874 A/G cg11946769 chr3:48343235 NME6 0.67 13.43 0.47 2.05e-36 Coronary artery disease; BRCA cis rs13256369 1.000 rs1109619 chr8:8571616 G/T cg17143192 chr8:8559678 CLDN23 0.54 10.38 0.38 1.9e-23 Obesity-related traits; BRCA cis rs9487051 0.802 rs6910696 chr6:109592329 A/T cg01475377 chr6:109611718 NA -0.57 -15.39 -0.52 1.07e-45 Reticulocyte fraction of red cells; BRCA cis rs992157 0.835 rs2292551 chr2:219143229 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.22 -0.41 8.71e-27 Colorectal cancer; BRCA cis rs9311474 0.507 rs4687644 chr3:52746541 T/G cg18404041 chr3:52824283 ITIH1 -0.39 -11.88 -0.43 1.43e-29 Electroencephalogram traits; BRCA cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg22974920 chr21:40686053 BRWD1 -0.36 -8.14 -0.31 2.1e-15 Menarche (age at onset); BRCA cis rs12493885 0.818 rs62276828 chr3:153775941 C/T cg17054900 chr3:154042577 DHX36 -0.5 -8.65 -0.32 4.07e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs709400 0.628 rs7155014 chr14:103863970 C/G cg26031613 chr14:104095156 KLC1 0.61 13.19 0.46 2.62e-35 Body mass index; BRCA cis rs6942756 0.659 rs624118 chr7:129096653 C/T cg02491457 chr7:128862824 NA -0.55 -11.39 -0.41 1.76e-27 White matter hyperintensity burden; BRCA cis rs6426558 0.515 rs7521110 chr1:227384459 T/A cg10327440 chr1:227177885 CDC42BPA -0.47 -9.36 -0.35 1.36e-19 Neutrophil percentage of white cells; BRCA cis rs7772486 0.701 rs697056 chr6:146003897 C/T cg23711669 chr6:146136114 FBXO30 -0.79 -18.77 -0.6 6.03e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs67478160 0.572 rs8016014 chr14:104293798 G/C cg26031613 chr14:104095156 KLC1 -0.46 -8.96 -0.33 3.46e-18 Schizophrenia; BRCA cis rs2625529 0.689 rs2957742 chr15:72302894 C/G cg16672083 chr15:72433130 SENP8 0.66 15.63 0.53 7.1e-47 Red blood cell count; BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.21 0.34 4.65e-19 Tonsillectomy; BRCA cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg26597838 chr10:835615 NA 1.01 17.82 0.58 5.87e-58 Eosinophil percentage of granulocytes; BRCA cis rs1801251 1.000 rs2044449 chr2:233718808 G/A cg25237894 chr2:233734115 C2orf82 -0.41 -11.84 -0.42 2.14e-29 Coronary artery disease; BRCA cis rs4780401 0.609 rs7205994 chr16:11815964 C/T cg01061890 chr16:11836724 TXNDC11 -0.57 -13.38 -0.47 3.53e-36 Rheumatoid arthritis; BRCA cis rs6973256 0.897 rs2909224 chr7:133331041 C/G cg07491979 chr7:133331646 EXOC4 -0.39 -8.8 -0.33 1.22e-17 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.530 rs9356996 chr6:26008487 C/A cg17691542 chr6:26056736 HIST1H1C 0.4 8.51 0.32 1.21e-16 Intelligence (multi-trait analysis); BRCA trans rs10242455 0.702 rs112475236 chr7:99044679 A/G cg09045935 chr12:6379348 NA 0.88 9.02 0.34 2.23e-18 Blood metabolite levels; BRCA cis rs1577917 0.958 rs12203457 chr6:86689277 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.1 -0.43 1.71e-30 Response to antipsychotic treatment; BRCA cis rs826838 0.684 rs12367400 chr12:38618673 G/T cg13010199 chr12:38710504 ALG10B 0.51 10.24 0.38 6.86e-23 Heart rate; BRCA cis rs62380364 0.602 rs448809 chr5:88005828 G/T cg22951263 chr5:87985283 NA -0.39 -10.77 -0.39 5.88e-25 Intelligence (multi-trait analysis); BRCA cis rs853679 0.517 rs9393894 chr6:28112562 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.96e-15 Depression; BRCA cis rs2115630 0.967 rs7171167 chr15:85239123 A/T cg12863693 chr15:85201151 NMB -0.33 -7.9 -0.3 1.26e-14 P wave terminal force; BRCA cis rs13118159 0.509 rs7688922 chr4:1361011 T/C cg02475777 chr4:1388615 CRIPAK 0.67 13.14 0.46 4.55e-35 Longevity; BRCA cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg12573674 chr2:1569213 NA -0.64 -14.4 -0.49 6.47e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9287719 0.934 rs4371336 chr2:10755723 C/A cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs586533 0.881 rs656031 chr11:99502178 G/T cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.47e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2991971 0.729 rs10890328 chr1:45905383 G/T cg24296786 chr1:45957014 TESK2 -0.53 -12.27 -0.44 3.09e-31 High light scatter reticulocyte count; BRCA cis rs7666738 0.830 rs7679299 chr4:99057620 C/A cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.5e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs597539 0.616 rs72945243 chr11:68633358 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.7 16.29 0.54 3.74e-50 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.93 -0.33 4.63e-18 Alzheimer's disease (late onset); BRCA cis rs6840360 0.615 rs72728171 chr4:152469372 C/A cg25486957 chr4:152246857 NA -0.36 -7.9 -0.3 1.26e-14 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg16606324 chr3:10149918 C3orf24 0.56 11.01 0.4 5.91e-26 Alzheimer's disease; BRCA cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -10.28 -0.38 4.63e-23 Schizophrenia; BRCA cis rs10504229 1.000 rs72650892 chr8:58179714 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs1371614 0.611 rs3910615 chr2:27131022 A/G cg12368169 chr2:27073192 DPYSL5 -0.29 -8.63 -0.32 5.05e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6542838 0.641 rs883773 chr2:99491635 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -8.98 -0.33 3.13e-18 Fear of minor pain; BRCA cis rs6598955 0.671 rs11579354 chr1:26604071 T/G cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs6435161 1.000 rs72927001 chr2:203530332 T/C cg18429434 chr2:203499731 FAM117B -0.45 -8.91 -0.33 5.44e-18 Total cholesterol levels; BRCA cis rs875971 0.862 rs908915 chr7:65614651 G/T cg11764359 chr7:65958608 NA -0.76 -17.47 -0.57 3.7e-56 Aortic root size; BRCA cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg02038168 chr22:39784481 NA 0.42 8.68 0.32 3.32e-17 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs7246657 0.882 rs28623164 chr19:37913453 G/A cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs780096 0.546 rs12473776 chr2:27636474 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.06 -0.34 1.62e-18 Total body bone mineral density; BRCA cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg11644478 chr21:40555479 PSMG1 -0.51 -10.83 -0.39 3.18e-25 Menarche (age at onset); BRCA cis rs10128251 0.962 rs4748018 chr10:5711507 T/A cg24097872 chr10:5724021 NA 0.51 11.08 0.4 3.12e-26 Childhood ear infection; BRCA cis rs2153535 0.542 rs915353 chr6:8440370 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.28 0.49 2.49e-40 Motion sickness; BRCA cis rs9790314 0.605 rs2593812 chr3:160703069 T/G cg03342759 chr3:160939853 NMD3 0.46 8.82 0.33 1.11e-17 Morning vs. evening chronotype; BRCA cis rs35110281 0.774 rs2838321 chr21:44995488 A/T cg21573476 chr21:45109991 RRP1B -0.36 -9.35 -0.35 1.5e-19 Mean corpuscular volume; BRCA cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.28 0.31 6.96e-16 Aortic root size; BRCA cis rs1468333 1.000 rs2906124 chr5:137528835 A/T cg27119451 chr5:137514611 BRD8;KIF20A 0.43 9.12 0.34 9.58e-19 Resting heart rate; BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.01 18.65 0.59 2.59e-62 Platelet count; BRCA cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg04455712 chr21:45112962 RRP1B 0.4 10.08 0.37 2.76e-22 Mean corpuscular volume; BRCA cis rs12986413 0.624 rs12460763 chr19:2138507 A/G cg09261902 chr19:2140048 AP3D1 0.41 10.83 0.39 3.17e-25 Height; BRCA cis rs10504229 0.683 rs2318147 chr8:58114931 C/T cg20607798 chr8:58055168 NA 0.6 9.1 0.34 1.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs11229555 0.574 rs12271501 chr11:58214969 T/C cg15696309 chr11:58395628 NA -0.45 -9.64 -0.36 1.27e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9790314 1.000 rs7638668 chr3:161047283 G/A cg03342759 chr3:160939853 NMD3 -0.65 -13.83 -0.48 3.01e-38 Morning vs. evening chronotype; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg13012494 chr21:47604986 C21orf56 -0.44 -8.72 -0.33 2.41e-17 Testicular germ cell tumor; BRCA cis rs2549003 1.000 rs10068129 chr5:131821246 A/G cg21138405 chr5:131827807 IRF1 -0.37 -12.09 -0.43 1.94e-30 Asthma (sex interaction); BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg09877947 chr5:131593287 PDLIM4 0.39 9.91 0.36 1.26e-21 Breast cancer; BRCA cis rs4566357 0.595 rs10206912 chr2:227921095 A/T cg11843606 chr2:227700838 RHBDD1 -0.44 -9.75 -0.36 4.97e-21 Coronary artery disease; BRCA cis rs1801251 1.000 rs6747645 chr2:233571033 C/T cg08000102 chr2:233561755 GIGYF2 -0.61 -13.4 -0.47 2.83e-36 Coronary artery disease; BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg27170947 chr2:26402098 FAM59B 0.64 10.92 0.4 1.44e-25 Gut microbiome composition (summer); BRCA cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg06238570 chr21:40685208 BRWD1 -0.39 -7.92 -0.3 1.06e-14 Menarche (age at onset); BRCA cis rs7666738 0.791 rs4699329 chr4:99056212 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.96 0.4 9.71e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.59 12.26 0.44 3.48e-31 Lymphocyte counts; BRCA cis rs7267979 1.000 rs34645895 chr20:25368373 A/G cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6964587 0.839 rs6949881 chr7:91433827 C/T cg17063962 chr7:91808500 NA 0.48 11.12 0.4 2.25e-26 Breast cancer; BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg08088566 chr11:430123 ANO9 0.56 8.3 0.31 6.17e-16 Body mass index; BRCA cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.34 -0.31 4.72e-16 Colorectal cancer; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.56 -0.42 3.28e-28 Lymphocyte counts; BRCA cis rs11190604 1.000 rs11190607 chr10:102303614 C/T cg07080220 chr10:102295463 HIF1AN 0.66 15.57 0.52 1.34e-46 Palmitoleic acid (16:1n-7) levels; BRCA cis rs11634851 0.966 rs34887414 chr15:81024204 T/C cg03950166 chr15:80988613 FAM108C1 -0.35 -7.93 -0.3 1.01e-14 Systolic blood pressure; BRCA cis rs875971 0.862 rs801194 chr7:66028495 T/C cg11764359 chr7:65958608 NA -0.76 -16.94 -0.56 1.88e-53 Aortic root size; BRCA cis rs4237845 0.837 rs7954957 chr12:58299250 C/T cg00677455 chr12:58241039 CTDSP2 0.45 10.73 0.39 8.25e-25 Intelligence (multi-trait analysis); BRCA cis rs1400816 0.850 rs2028671 chr2:172852839 C/T cg13550731 chr2:172543902 DYNC1I2 -0.51 -7.87 -0.3 1.56e-14 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg03709012 chr19:19516395 GATAD2A 0.81 19.03 0.6 2.53e-64 Tonsillectomy; BRCA cis rs6545883 0.929 rs7563678 chr2:61741811 C/T cg15711740 chr2:61764176 XPO1 0.52 13.03 0.46 1.32e-34 Tuberculosis; BRCA cis rs2404602 0.647 rs11631959 chr15:77040048 T/C cg23625390 chr15:77176239 SCAPER -0.55 -13.85 -0.48 2.39e-38 Blood metabolite levels; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg18765753 chr7:1198926 ZFAND2A -0.4 -9.05 -0.34 1.69e-18 Longevity;Endometriosis; BRCA cis rs68092024 0.704 rs704576 chr3:99487154 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -10.53 -0.38 5.12e-24 Cleft lip with or without cleft palate; BRCA cis rs4481887 0.962 rs10788770 chr1:248457474 T/G cg00666640 chr1:248458726 OR2T12 0.35 8.92 0.33 4.98e-18 Common traits (Other); BRCA cis rs2624839 0.602 rs2526398 chr3:50187596 G/C cg05623727 chr3:50126028 RBM5 0.4 8.55 0.32 9.42e-17 Intelligence (multi-trait analysis); BRCA cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg03433033 chr1:76189801 ACADM -0.46 -8.95 -0.33 3.76e-18 Daytime sleep phenotypes; BRCA cis rs7246657 0.943 rs2891699 chr19:37920237 A/G cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs4665809 0.590 rs34728554 chr2:26481959 C/G cg25036284 chr2:26402008 FAM59B 0.94 15.92 0.53 2.57e-48 Gut microbiome composition (summer); BRCA cis rs4845570 1.000 rs3811415 chr1:151763767 C/T cg07092448 chr1:151763213 TDRKH -0.94 -16.25 -0.54 5.77e-50 Coronary artery disease; BRCA trans rs9784649 0.760 rs17403440 chr5:25054004 C/T cg08600765 chr20:34638493 LOC647979 -0.68 -11.73 -0.42 6.31e-29 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs7824557 0.591 rs2736283 chr8:11225910 A/G cg06636001 chr8:8085503 FLJ10661 -0.4 -7.94 -0.3 9.44e-15 Retinal vascular caliber; BRCA cis rs11718455 1.000 rs28731098 chr3:44019816 A/C cg08738300 chr3:44038990 NA 0.44 8.56 0.32 8.6e-17 Coronary artery disease; BRCA cis rs801193 0.569 rs6978178 chr7:66123084 G/A cg18876405 chr7:65276391 NA -0.49 -10.88 -0.4 2.14e-25 Aortic root size; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.93e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs877282 1.000 rs2004479 chr10:770854 G/A cg22713356 chr15:30763199 NA 1.23 24.66 0.7 7.46e-95 Uric acid levels; BRCA cis rs9527 0.590 rs3740386 chr10:104931051 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.12 0.37 1.97e-22 Arsenic metabolism; BRCA cis rs11190604 1.000 rs11190552 chr10:102206607 G/A cg07080220 chr10:102295463 HIF1AN 0.49 11.15 0.4 1.7e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs738322 0.934 rs133019 chr22:38573035 A/G cg25457927 chr22:38595422 NA -0.36 -13.4 -0.47 2.98e-36 Cutaneous nevi; BRCA cis rs73001065 0.636 rs11668104 chr19:19426181 G/A cg03709012 chr19:19516395 GATAD2A 0.92 13.87 0.48 2.02e-38 LDL cholesterol; BRCA cis rs17401966 0.838 rs7553935 chr1:10375179 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.56 0.47 5.39e-37 Hepatocellular carcinoma; BRCA cis rs6500602 0.855 rs2304631 chr16:4475868 A/T cg08645402 chr16:4508243 NA 0.39 8.5 0.32 1.31e-16 Schizophrenia; BRCA cis rs2842992 0.915 rs2758335 chr6:160111011 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.43 0.55 7.1e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs7586673 0.964 rs34444368 chr2:161954217 G/A cg22496339 chr2:162101262 NA 0.41 8.08 0.3 3.2e-15 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg11833968 chr6:79620685 NA -0.41 -8.94 -0.33 4.1e-18 Intelligence (multi-trait analysis); BRCA cis rs8072100 0.967 rs4580230 chr17:45738861 G/A cg08085267 chr17:45401833 C17orf57 -0.67 -14.83 -0.51 5.78e-43 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9733 0.596 rs72702585 chr1:150696427 G/A cg17724175 chr1:150552817 MCL1 0.25 8.21 0.31 1.27e-15 Tonsillectomy; BRCA cis rs3099143 1.000 rs2046415 chr15:77085253 A/G cg21673338 chr15:77095150 SCAPER -0.53 -9.46 -0.35 5.82e-20 Recalcitrant atopic dermatitis; BRCA cis rs2404602 1.000 rs1117367 chr15:76872330 A/C cg23625390 chr15:77176239 SCAPER 0.39 9.56 0.35 2.41e-20 Blood metabolite levels; BRCA trans rs9291683 0.609 rs12507050 chr4:10007305 G/T cg26043149 chr18:55253948 FECH 0.4 8.48 0.32 1.59e-16 Bone mineral density; BRCA cis rs17539620 0.624 rs62432743 chr6:154836214 T/G cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.21e-40 Motion sickness; BRCA cis rs1008375 0.606 rs6828925 chr4:17561139 C/T cg04450456 chr4:17643702 FAM184B 0.29 8.42 0.32 2.4e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg18765753 chr7:1198926 ZFAND2A -0.48 -11.84 -0.42 2.27e-29 Longevity;Endometriosis; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg16431978 chr21:31797932 KRTAP13-3 0.37 9.45 0.35 6.12e-20 HDL cholesterol; BRCA cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg07636037 chr3:49044803 WDR6 0.46 9.23 0.34 3.96e-19 Resting heart rate; BRCA cis rs2463822 1.000 rs2513074 chr11:62100880 A/C cg06239285 chr11:62104954 ASRGL1 0.66 11.05 0.4 4.1e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs3858526 0.883 rs10769320 chr11:5932831 G/C cg25319279 chr11:5960081 NA -0.41 -8.05 -0.3 4.18e-15 DNA methylation (variation); BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 21.22 0.64 4.94e-76 Platelet count; BRCA cis rs9858542 0.953 rs9824092 chr3:49674147 C/G cg03060546 chr3:49711283 APEH -0.58 -11.84 -0.42 2.29e-29 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs11098499 0.908 rs1002152 chr4:120273387 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.12 0.31 2.44e-15 Corneal astigmatism; BRCA cis rs801193 0.569 rs3846973 chr7:66120035 T/C cg18876405 chr7:65276391 NA -0.49 -10.81 -0.39 3.86e-25 Aortic root size; BRCA cis rs6570726 1.000 rs404229 chr6:145868200 G/A cg23711669 chr6:146136114 FBXO30 0.63 14.76 0.5 1.25e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg03146154 chr1:46216737 IPP 0.49 10.89 0.4 1.84e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs4596713 0.507 rs9314865 chr9:71801495 A/G cg16512924 chr15:28394682 HERC2 0.45 10.64 0.39 1.81e-24 Headache; BRCA cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg17691542 chr6:26056736 HIST1H1C -0.7 -12.65 -0.45 6.62e-33 Iron status biomarkers; BRCA cis rs17345786 0.511 rs1138818 chr3:101399583 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.84 0.51 5.21e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6684514 1.000 rs2296375 chr1:156309372 G/C cg16558208 chr1:156270281 VHLL 0.36 7.99 0.3 6.51e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA trans rs2727020 0.729 rs10742932 chr11:49173234 T/C cg11707556 chr5:10655725 ANKRD33B -0.37 -8.58 -0.32 7.09e-17 Coronary artery disease; BRCA cis rs4237845 0.537 rs4237844 chr12:58267987 A/G cg00677455 chr12:58241039 CTDSP2 -0.69 -15.82 -0.53 7.91e-48 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.561 rs3733584 chr4:10036506 T/C cg00071950 chr4:10020882 SLC2A9 0.64 16.0 0.53 1.06e-48 Bone mineral density; BRCA cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg05283184 chr6:79620031 NA -0.43 -11.4 -0.41 1.54e-27 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs898097 0.625 rs6502017 chr17:80891135 C/T cg15664640 chr17:80829946 TBCD 0.41 10.99 0.4 7.71e-26 Breast cancer; BRCA trans rs6952808 0.531 rs1107351 chr7:2177093 G/A cg04565464 chr8:145669602 NFKBIL2 0.41 8.75 0.33 1.96e-17 Bipolar disorder and schizophrenia; BRCA cis rs8103278 0.507 rs3745802 chr19:46271177 G/T cg11657440 chr19:46296263 DMWD 0.71 19.05 0.6 2.06e-64 Coronary artery disease; BRCA cis rs9287719 0.967 rs10195802 chr2:10754532 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs701145 0.585 rs1727879 chr3:153835819 C/T cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.2e-14 Coronary artery disease; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.05 0.58 3.73e-59 Platelet count; BRCA cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.82 0.39 3.46e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs992157 0.687 rs35271699 chr2:219117482 G/A cg00012203 chr2:219082015 ARPC2 0.72 16.21 0.54 9.19e-50 Colorectal cancer; BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg00149659 chr3:10157352 C3orf10 0.8 13.73 0.48 9.11e-38 Alzheimer's disease; BRCA cis rs12545109 0.879 rs1581129 chr8:57377476 T/C cg09654669 chr8:57350985 NA -0.46 -8.69 -0.33 3.08e-17 Obesity-related traits; BRCA cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg09184832 chr6:79620586 NA -0.48 -10.83 -0.39 3.17e-25 Intelligence (multi-trait analysis); BRCA trans rs1005277 0.522 rs1208684 chr10:38093936 G/A cg17830980 chr10:43048298 ZNF37B -0.42 -9.73 -0.36 5.81e-21 Extrinsic epigenetic age acceleration; BRCA cis rs561341 0.943 rs508566 chr17:30289861 G/C cg12193833 chr17:30244370 NA -0.54 -8.56 -0.32 8.58e-17 Hip circumference adjusted for BMI; BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg11814155 chr7:99998594 ZCWPW1 0.47 8.41 0.32 2.62e-16 Platelet count; BRCA trans rs1493916 0.905 rs1586988 chr18:31396001 G/C cg15819921 chr19:927150 ARID3A -0.52 -9.67 -0.36 1.01e-20 Life satisfaction; BRCA cis rs924607 1.000 rs1697978 chr5:642829 A/G cg09021430 chr5:549028 NA -0.43 -12.35 -0.44 1.37e-31 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs9287719 0.967 rs7563894 chr2:10754649 A/G cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.81e-23 Prostate cancer; BRCA cis rs8177253 0.761 rs1830083 chr3:133508551 G/A cg11941060 chr3:133502564 NA -0.59 -14.83 -0.51 5.7e-43 Iron status biomarkers; BRCA cis rs4268898 0.722 rs6723257 chr2:24391129 A/G cg26838691 chr2:24397539 C2orf84 0.4 8.07 0.3 3.41e-15 Asthma; BRCA cis rs17092148 0.652 rs6088515 chr20:33110042 C/T cg16810054 chr20:33298113 TP53INP2 -0.43 -9.35 -0.35 1.51e-19 Neuroticism; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg13880726 chr7:1868755 MAD1L1 0.52 9.78 0.36 3.94e-21 Bipolar disorder and schizophrenia; BRCA cis rs2204008 0.591 rs11495396 chr12:38380182 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.4 0.38 1.67e-23 Bladder cancer; BRCA cis rs36051895 0.659 rs7046511 chr9:5045695 C/T cg02405213 chr9:5042618 JAK2 -0.5 -9.59 -0.35 1.9e-20 Pediatric autoimmune diseases; BRCA cis rs4730250 0.707 rs257382 chr7:106804249 A/G cg02696742 chr7:106810147 HBP1 -0.57 -9.46 -0.35 5.66e-20 Osteoarthritis; BRCA cis rs11098499 0.754 rs10006259 chr4:120242145 C/T cg09307838 chr4:120376055 NA 0.64 13.93 0.48 1.02e-38 Corneal astigmatism; BRCA cis rs6495367 0.898 rs1443658 chr15:79386366 A/G cg17916960 chr15:79447300 NA 0.38 9.01 0.34 2.4e-18 Spherical equivalent (joint analysis main effects and education interaction); BRCA trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -9.87 -0.36 1.79e-21 Triglycerides; BRCA trans rs9951602 1.000 rs1903723 chr18:76646571 A/G cg02800362 chr5:177631904 HNRNPAB 0.76 13.09 0.46 7.5e-35 Obesity-related traits; BRCA cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg16950941 chr11:66035639 RAB1B 0.42 11.87 0.43 1.67e-29 Gout; BRCA cis rs736408 0.545 rs6445529 chr3:52662722 T/A cg11041457 chr3:52719354 GNL3;PBRM1 0.39 13.48 0.47 1.29e-36 Bipolar disorder; BRCA cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg18876405 chr7:65276391 NA -0.56 -13.29 -0.47 8.93e-36 Aortic root size; BRCA cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg15145296 chr3:125709740 NA -0.55 -8.69 -0.33 3.04e-17 Blood pressure (smoking interaction); BRCA cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg22800045 chr5:56110881 MAP3K1 0.65 12.18 0.43 7.48e-31 Initial pursuit acceleration; BRCA cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg27478167 chr7:817139 HEATR2 -0.4 -8.95 -0.33 3.98e-18 Cerebrospinal P-tau181p levels; BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg00106254 chr7:1943704 MAD1L1 -0.41 -10.08 -0.37 2.79e-22 Bipolar disorder and schizophrenia; BRCA cis rs679087 1.000 rs672107 chr12:29917266 T/A cg14258853 chr12:29935411 TMTC1 -0.42 -8.85 -0.33 8.36e-18 Schizophrenia; BRCA cis rs12497850 0.543 rs6446218 chr3:49075513 A/T cg07636037 chr3:49044803 WDR6 0.98 28.87 0.75 6.39e-118 Parkinson's disease; BRCA cis rs724568 0.546 rs1430769 chr2:67932210 A/T cg17945962 chr2:67939740 NA -0.38 -9.93 -0.37 1.02e-21 Major depressive disorder (broad); BRCA trans rs6952808 0.595 rs3800917 chr7:2167939 A/G cg04565464 chr8:145669602 NFKBIL2 -0.4 -9.03 -0.34 2.01e-18 Bipolar disorder and schizophrenia; BRCA cis rs7615952 0.932 rs11922218 chr3:125631289 C/T cg05084668 chr3:125655381 ALG1L -0.55 -9.0 -0.34 2.63e-18 Blood pressure (smoking interaction); BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg21280719 chr6:42927975 GNMT 0.33 13.66 0.48 1.83e-37 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7659604 0.702 rs61217486 chr4:122693973 T/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.4 -0.44 8.74e-32 Type 2 diabetes; BRCA cis rs61931739 0.500 rs10844846 chr12:34394611 C/G cg06521331 chr12:34319734 NA -0.51 -10.12 -0.37 1.93e-22 Morning vs. evening chronotype; BRCA cis rs4824093 0.610 rs4141437 chr22:50243719 C/G cg22709217 chr22:50311962 ALG12;CRELD2 0.65 8.01 0.3 5.62e-15 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg18402987 chr7:1209562 NA 0.87 12.28 0.44 2.89e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7829975 0.508 rs4841006 chr8:8501474 T/C cg06636001 chr8:8085503 FLJ10661 -0.48 -10.16 -0.37 1.35e-22 Mood instability; BRCA trans rs61931739 0.534 rs4931772 chr12:34044590 G/A cg13010199 chr12:38710504 ALG10B 0.4 8.09 0.3 3.05e-15 Morning vs. evening chronotype; BRCA cis rs10193935 0.901 rs62142599 chr2:42548935 G/A cg27598129 chr2:42591480 NA -0.65 -11.03 -0.4 5.17e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg00409905 chr10:38381863 ZNF37A 0.45 9.22 0.34 4.18e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg13047869 chr3:10149882 C3orf24 0.53 10.94 0.4 1.14e-25 Alzheimer's disease; BRCA cis rs826838 1.000 rs11169031 chr12:39056738 T/C cg26384229 chr12:38710491 ALG10B 0.83 22.36 0.66 2.87e-82 Heart rate; BRCA cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg06064525 chr11:970664 AP2A2 -0.32 -9.67 -0.36 9.52e-21 Alzheimer's disease (late onset); BRCA cis rs7647973 0.626 rs6809879 chr3:49834571 A/G cg03060546 chr3:49711283 APEH -0.58 -9.91 -0.37 1.2e-21 Menarche (age at onset); BRCA cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg00071950 chr4:10020882 SLC2A9 -0.54 -12.63 -0.45 8.09e-33 Bone mineral density; BRCA cis rs6088580 0.602 rs6059840 chr20:33030405 G/A cg24642439 chr20:33292090 TP53INP2 0.54 11.72 0.42 6.97e-29 Glomerular filtration rate (creatinine); BRCA cis rs11190604 1.000 rs3750720 chr10:102248884 C/T cg07080220 chr10:102295463 HIF1AN 0.57 12.13 0.43 1.31e-30 Palmitoleic acid (16:1n-7) levels; BRCA cis rs709400 0.663 rs2273703 chr14:103918029 C/G cg12935359 chr14:103987150 CKB -0.58 -13.69 -0.48 1.36e-37 Body mass index; BRCA trans rs208520 0.690 rs851465 chr6:66840293 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.02 -0.64 6.06e-75 Exhaled nitric oxide output; BRCA cis rs11690462 0.528 rs11691698 chr2:26642190 A/G cg04944784 chr2:26401820 FAM59B 0.49 8.13 0.31 2.17e-15 Coronary artery disease; BRCA trans rs877282 0.947 rs4133015 chr10:774131 T/C cg22713356 chr15:30763199 NA 1.15 23.26 0.68 3.6e-87 Uric acid levels; BRCA cis rs6831352 0.918 rs2851248 chr4:100045974 A/G cg13256891 chr4:100009986 ADH5 0.49 9.25 0.34 3.45e-19 Alcohol dependence; BRCA cis rs7267979 0.903 rs2474769 chr20:25248725 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.52 0.32 1.13e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4363385 0.818 rs435633 chr1:153011811 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs10992471 0.639 rs10821008 chr9:95487497 C/T cg14631576 chr9:95140430 CENPP -0.32 -7.86 -0.3 1.68e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs636291 0.517 rs55935829 chr1:10540926 A/T cg07384165 chr1:10488281 NA -0.41 -8.77 -0.33 1.62e-17 Prostate cancer; BRCA cis rs875971 0.619 rs12533585 chr7:65984605 G/C cg18876405 chr7:65276391 NA 0.62 15.49 0.52 3.58e-46 Aortic root size; BRCA cis rs6938 0.534 rs7495739 chr15:75185670 C/T cg14664628 chr15:75095509 CSK 0.54 13.08 0.46 8.68e-35 Breast cancer; BRCA cis rs4660306 0.961 rs4660867 chr1:45986484 A/G cg24296786 chr1:45957014 TESK2 0.43 8.66 0.32 3.96e-17 Homocysteine levels; BRCA cis rs17601876 0.814 rs35939475 chr15:51554710 C/A cg19946085 chr15:51559439 CYP19A1 -0.38 -11.06 -0.4 3.7e-26 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs6963495 0.818 rs73192113 chr7:105169603 C/T cg19920283 chr7:105172520 RINT1 0.59 9.46 0.35 5.64e-20 Bipolar disorder (body mass index interaction); BRCA cis rs17711722 0.675 rs6947132 chr7:65273495 G/A cg18876405 chr7:65276391 NA -0.71 -18.73 -0.6 1.04e-62 Calcium levels; BRCA cis rs10870270 1.000 rs7078692 chr10:133775370 T/A cg08754478 chr10:133766260 PPP2R2D -0.68 -14.11 -0.49 1.44e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs1801251 1.000 rs13013142 chr2:233600606 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.55 0.42 3.79e-28 Coronary artery disease; BRCA cis rs61931739 0.534 rs4001713 chr12:34154195 A/C cg06521331 chr12:34319734 NA 0.61 11.22 0.41 8.44e-27 Morning vs. evening chronotype; BRCA cis rs1371614 0.655 rs509047 chr2:27128529 T/C cg00617064 chr2:27272375 NA 0.3 8.07 0.3 3.42e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7789940 0.857 rs12532935 chr7:75939698 G/C cg24663003 chr7:76039223 ZP3;SRCRB4D 0.36 7.84 0.3 1.83e-14 Multiple sclerosis; BRCA cis rs2576037 0.526 rs2051292 chr18:44484372 C/G cg19077165 chr18:44547161 KATNAL2 -0.49 -10.16 -0.37 1.36e-22 Personality dimensions; BRCA cis rs6570726 0.818 rs399516 chr6:145810849 C/A cg23711669 chr6:146136114 FBXO30 0.65 15.14 0.51 1.84e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs738322 1.000 rs133009 chr22:38569653 G/C cg25457927 chr22:38595422 NA -0.32 -11.88 -0.43 1.54e-29 Cutaneous nevi; BRCA cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.22e-41 Motion sickness; BRCA cis rs9815354 0.812 rs17283929 chr3:41941898 C/G cg03022575 chr3:42003672 ULK4 -0.7 -9.84 -0.36 2.26e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs6912958 0.712 rs7755167 chr6:88338752 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.36 -0.31 3.96e-16 Monocyte percentage of white cells; BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg07343612 chr16:622815 PIGQ -0.66 -21.11 -0.64 1.87e-75 Height; BRCA cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg14664628 chr15:75095509 CSK -0.94 -29.77 -0.76 7.73e-123 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs3820928 0.874 rs13383070 chr2:227904939 C/T cg11843606 chr2:227700838 RHBDD1 -0.37 -8.39 -0.32 3.03e-16 Pulmonary function; BRCA cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15506890 chr2:3487001 NA -0.58 -13.14 -0.46 4.26e-35 Neurofibrillary tangles; BRCA trans rs7829975 0.688 rs13270194 chr8:8378102 T/C cg21775007 chr8:11205619 TDH 0.44 9.06 0.34 1.63e-18 Mood instability; BRCA cis rs1862618 0.573 rs1550821 chr5:56242323 C/T cg24531977 chr5:56204891 C5orf35 1.07 22.52 0.67 4.17e-83 Initial pursuit acceleration; BRCA cis rs13256369 0.901 rs12681327 chr8:8566414 G/T cg06671706 chr8:8559999 CLDN23 0.44 8.43 0.32 2.22e-16 Obesity-related traits; BRCA cis rs17376456 0.877 rs55832164 chr5:93436579 C/T cg25358565 chr5:93447407 FAM172A 1.2 19.15 0.6 6.01e-65 Diabetic retinopathy; BRCA cis rs9287719 0.649 rs10198971 chr2:10718699 G/C cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.62e-19 Prostate cancer; BRCA cis rs16870629 0.564 rs326050 chr5:1002620 C/T cg00278107 chr5:1061253 SLC12A7 0.58 11.34 0.41 2.81e-27 QT interval; BRCA cis rs586533 0.837 rs605937 chr11:99499253 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs597539 0.652 rs674654 chr11:68698762 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 18.14 0.58 1.24e-59 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7249142 0.597 rs759999 chr19:19281207 A/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.42 -8.99 -0.34 2.81e-18 IgG glycosylation; BRCA trans rs11098499 0.618 rs6858383 chr4:120296772 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg23711669 chr6:146136114 FBXO30 0.71 13.96 0.48 7.68e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.790 rs80050589 chr6:146230454 T/C cg13319975 chr6:146136371 FBXO30 0.41 9.35 0.35 1.49e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs847577 0.722 rs7790120 chr7:97712831 C/A cg21770322 chr7:97807741 LMTK2 0.57 16.23 0.54 7.07e-50 Breast cancer; BRCA cis rs4891159 0.548 rs690414 chr18:74117840 T/C cg24786174 chr18:74118243 ZNF516 0.84 26.04 0.72 1.91e-102 Longevity; BRCA cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg06108461 chr20:60628389 TAF4 0.5 8.31 0.31 5.62e-16 Obesity-related traits; BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg13047869 chr3:10149882 C3orf24 0.55 11.49 0.41 6.78e-28 Alzheimer's disease; BRCA cis rs6088580 0.602 rs6059834 chr20:33019299 A/G cg24642439 chr20:33292090 TP53INP2 0.54 11.77 0.42 4.61e-29 Glomerular filtration rate (creatinine); BRCA cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14240646 chr10:27532245 ACBD5 0.53 8.58 0.32 7.22e-17 Breast cancer; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.95 0.43 7.69e-30 Tonsillectomy; BRCA cis rs9308433 0.529 rs55760458 chr1:214491536 G/C cg06198575 chr1:214491504 SMYD2 0.58 12.6 0.45 1.13e-32 IgG glycosylation; BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.76 0.67 2.09e-84 Platelet count; BRCA cis rs7914558 0.966 rs7096269 chr10:104736721 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.79 0.39 4.71e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6912958 0.874 rs9294381 chr6:88152681 A/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -9.2 -0.34 5.08e-19 Monocyte percentage of white cells; BRCA cis rs7772486 0.754 rs9386134 chr6:146145508 G/A cg05347473 chr6:146136440 FBXO30 0.45 8.85 0.33 8.22e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.671 rs906631 chr5:56245803 C/G cg24531977 chr5:56204891 C5orf35 0.71 15.44 0.52 6.37e-46 Initial pursuit acceleration; BRCA cis rs9790314 0.967 rs6762645 chr3:160948349 T/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.05 -0.49 2.95e-39 Morning vs. evening chronotype; BRCA trans rs2727020 0.786 rs10839263 chr11:49354462 A/G cg15704280 chr7:45808275 SEPT13 -0.73 -14.95 -0.51 1.46e-43 Coronary artery disease; BRCA cis rs2806561 0.929 rs628096 chr1:23537676 C/G cg12483005 chr1:23474871 LUZP1 0.37 8.02 0.3 4.97e-15 Height; BRCA cis rs6088590 1.000 rs6088595 chr20:33358499 T/A cg08999081 chr20:33150536 PIGU 0.37 8.72 0.33 2.41e-17 Coronary artery disease; BRCA cis rs372883 0.563 rs1153293 chr21:30691325 C/T cg24692254 chr21:30365293 RNF160 0.5 10.88 0.4 1.98e-25 Pancreatic cancer; BRCA cis rs17270561 0.609 rs1318016 chr6:25764704 A/T cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs11098499 0.779 rs10016060 chr4:120298412 A/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs67460515 0.500 rs1868105 chr3:160645335 A/G cg03342759 chr3:160939853 NMD3 -0.65 -12.89 -0.45 5.81e-34 Parkinson's disease; BRCA cis rs847577 0.722 rs1013887 chr7:97709345 G/T cg24562669 chr7:97807699 LMTK2 0.54 15.7 0.53 3.21e-47 Breast cancer; BRCA cis rs514406 0.792 rs481440 chr1:53344976 C/T cg25767906 chr1:53392781 SCP2 -0.45 -10.15 -0.37 1.57e-22 Monocyte count; BRCA cis rs3784262 0.669 rs3784259 chr15:58257847 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.07 -0.37 3.01e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2153535 0.601 rs4960414 chr6:8438541 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.37 0.49 8.98e-41 Motion sickness; BRCA cis rs561341 1.000 rs117029332 chr17:30266085 C/G cg23018236 chr17:30244563 NA -0.71 -11.12 -0.4 2.27e-26 Hip circumference adjusted for BMI; BRCA cis rs2540552 0.600 rs62467818 chr7:91199485 A/G cg15143024 chr7:91199642 NA -0.46 -11.59 -0.42 2.57e-28 IgG glycosylation; BRCA cis rs7666738 0.830 rs3852122 chr4:98697400 T/C cg05340658 chr4:99064831 C4orf37 0.63 15.11 0.51 2.54e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.655 rs2268193 chr6:41024625 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.68 -0.36 9.11e-21 Alzheimer's disease (late onset); BRCA cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg06671706 chr8:8559999 CLDN23 0.43 8.41 0.32 2.77e-16 Obesity-related traits; BRCA cis rs7246657 0.943 rs4803229 chr19:37864682 T/G cg23950597 chr19:37808831 NA -0.62 -11.36 -0.41 2.35e-27 Coronary artery calcification; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.31 -0.44 2.07e-31 Lymphocyte counts; BRCA cis rs8017423 0.607 rs10142482 chr14:90848280 G/T cg04374321 chr14:90722782 PSMC1 -0.5 -11.44 -0.41 1.02e-27 Mortality in heart failure; BRCA cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg18402987 chr7:1209562 NA 0.87 9.18 0.34 5.73e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7577696 0.525 rs2366547 chr2:32251109 G/A cg02381751 chr2:32503542 YIPF4 -0.42 -7.99 -0.3 6.3e-15 Inflammatory biomarkers; BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg19010396 chr19:19431384 KIAA0892;SF4 0.45 8.98 0.33 2.91e-18 Tonsillectomy; BRCA cis rs4853036 0.904 rs13015957 chr2:70032316 C/T cg02498382 chr2:70120550 SNRNP27 -0.49 -8.93 -0.33 4.53e-18 Colorectal or endometrial cancer; BRCA cis rs10493773 0.609 rs3753789 chr1:86174814 T/C cg17807903 chr1:86174739 ZNHIT6 -0.53 -13.2 -0.46 2.36e-35 Urate levels in overweight individuals; BRCA cis rs7819412 0.668 rs920047 chr8:11087475 C/T cg21775007 chr8:11205619 TDH -0.38 -7.82 -0.3 2.25e-14 Triglycerides; BRCA cis rs34311866 0.752 rs11725653 chr4:963397 C/T cg14530993 chr4:882597 GAK 0.51 8.69 0.33 2.94e-17 Parkinson's disease; BRCA cis rs17655565 0.533 rs12825729 chr12:52706854 G/A cg08257133 chr12:52711352 KRT83 0.37 10.79 0.39 4.77e-25 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs514406 0.698 rs567880 chr1:53348564 T/G cg24675658 chr1:53192096 ZYG11B -0.68 -15.47 -0.52 4.56e-46 Monocyte count; BRCA cis rs7927771 0.832 rs6485753 chr11:47410200 C/T cg18512352 chr11:47633146 NA 0.32 8.06 0.3 3.73e-15 Subjective well-being; BRCA cis rs9287719 0.870 rs728135 chr2:10745132 A/C cg02196655 chr2:10830764 NOL10 -0.3 -8.05 -0.3 4.13e-15 Prostate cancer; BRCA cis rs2204008 0.677 rs1581356 chr12:38391467 T/C cg13010199 chr12:38710504 ALG10B 0.43 8.89 0.33 6.05e-18 Bladder cancer; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg22907277 chr7:1156413 C7orf50 0.47 10.69 0.39 1.16e-24 Longevity;Endometriosis; BRCA cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg00701064 chr4:6280414 WFS1 0.66 16.07 0.54 4.74e-49 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9467711 0.591 rs13206501 chr6:26110148 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.49 0.35 4.65e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs4925386 0.765 rs6142737 chr20:60919800 C/G cg24112000 chr20:60950667 NA -0.48 -9.23 -0.34 4.06e-19 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs870825 0.616 rs6552805 chr4:185637894 C/A cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs17685 0.725 rs6467993 chr7:75719350 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.43 -9.66 -0.36 1.03e-20 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs30380 0.922 rs246453 chr5:96123336 T/C cg16492584 chr5:96139282 ERAP1 -0.31 -7.96 -0.3 7.6e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg04267008 chr7:1944627 MAD1L1 -0.6 -13.46 -0.47 1.53e-36 Bipolar disorder and schizophrenia; BRCA cis rs17604090 0.823 rs28415620 chr7:29701104 T/C cg19413766 chr7:29689036 LOC646762 -0.61 -8.16 -0.31 1.85e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs644148 0.836 rs2686774 chr19:44999827 T/C cg15540054 chr19:45004280 ZNF180 -0.57 -12.28 -0.44 2.9e-31 Personality dimensions; BRCA cis rs17270561 0.583 rs6926425 chr6:25785304 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 9.69 0.36 8.1e-21 Iron status biomarkers; BRCA cis rs35110281 0.720 rs230647 chr21:44919654 C/T cg04455712 chr21:45112962 RRP1B -0.43 -10.04 -0.37 4.03e-22 Mean corpuscular volume; BRCA cis rs2677744 0.626 rs11854429 chr15:91489685 C/T cg23684204 chr15:91497937 RCCD1 -0.41 -8.46 -0.32 1.89e-16 Attention deficit hyperactivity disorder; BRCA cis rs6435161 0.919 rs72928971 chr2:203591967 A/G cg18429434 chr2:203499731 FAM117B -0.42 -8.54 -0.32 9.53e-17 Total cholesterol levels; BRCA cis rs6121246 0.909 rs6119651 chr20:30259246 G/T cg21427119 chr20:30132790 HM13 -0.41 -8.8 -0.33 1.32e-17 Mean corpuscular hemoglobin; BRCA cis rs13046373 0.535 rs8129571 chr21:31980646 G/A cg14062083 chr21:31802829 KRTAP13-4 0.35 9.51 0.35 3.76e-20 HDL cholesterol; BRCA cis rs950776 0.714 rs660652 chr15:78887832 A/G cg06917634 chr15:78832804 PSMA4 -0.55 -11.6 -0.42 2.18e-28 Sudden cardiac arrest; BRCA trans rs9291683 0.609 rs13141233 chr4:10028729 T/C cg26043149 chr18:55253948 FECH 0.41 8.91 0.33 5.1e-18 Bone mineral density; BRCA cis rs4689592 0.546 rs10937782 chr4:7057106 G/C cg26116260 chr4:7069785 GRPEL1 0.89 25.38 0.71 8.08e-99 Monocyte percentage of white cells; BRCA cis rs6867032 0.834 rs4526149 chr5:1990166 G/A cg26168224 chr5:2018326 NA -0.54 -13.04 -0.46 1.25e-34 Gut microbiome composition (winter); BRCA cis rs4604732 0.536 rs4925674 chr1:247636906 C/T cg02104434 chr1:247694406 LOC148824;OR2C3 0.4 7.83 0.3 2.05e-14 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid); BRCA cis rs7666738 0.830 rs10028505 chr4:98962310 C/A cg05340658 chr4:99064831 C4orf37 0.68 16.96 0.56 1.53e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs6582630 0.555 rs10880544 chr12:38473464 G/C cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.32e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7914558 1.000 rs7077097 chr10:104945463 G/A cg04362960 chr10:104952993 NT5C2 0.42 10.13 0.37 1.77e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs11098499 0.866 rs3756156 chr4:120524841 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 8.78e-16 Corneal astigmatism; BRCA cis rs11585357 0.671 rs2501776 chr1:17619279 C/T cg08277548 chr1:17600880 PADI3 0.44 8.85 0.33 8.72e-18 Hair shape; BRCA cis rs61931739 0.500 rs56404399 chr12:34543101 A/G cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs2304069 0.954 rs1962603 chr5:149393006 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.82 16.61 0.55 9.35e-52 HIV-1 control; BRCA cis rs8038465 0.615 rs6495076 chr15:73982965 G/A cg15420318 chr15:73925796 NPTN 0.38 8.72 0.33 2.37e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg22920501 chr2:26401640 FAM59B -0.91 -17.48 -0.57 3.17e-56 Gut microbiome composition (summer); BRCA cis rs941873 0.868 rs7898 chr10:81114959 C/T cg11057378 chr10:81107060 PPIF 0.36 8.83 0.33 9.91e-18 Height; BRCA cis rs7944584 0.511 rs10838725 chr11:47557871 T/C cg20307385 chr11:47447363 PSMC3 0.8 19.14 0.6 6.89e-65 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg13736514 chr6:26305472 NA -0.36 -12.25 -0.44 3.7e-31 Educational attainment; BRCA cis rs7944584 0.879 rs11039182 chr11:47346723 T/C cg20307385 chr11:47447363 PSMC3 0.62 11.95 0.43 7.94e-30 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs17401966 0.931 rs10864448 chr1:10277497 A/T cg03954927 chr1:10346856 KIF1B 0.48 14.75 0.5 1.29e-42 Hepatocellular carcinoma; BRCA cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg00031303 chr3:195681400 NA 0.46 8.67 0.32 3.6e-17 Pancreatic cancer; BRCA cis rs79976124 0.879 rs77185357 chr6:66629070 G/A cg07460842 chr6:66804631 NA 0.59 10.19 0.37 1.06e-22 Type 2 diabetes; BRCA cis rs2075371 1.000 rs2544210 chr7:133971535 C/T cg20476274 chr7:133979776 SLC35B4 0.69 20.55 0.63 1.96e-72 Mean platelet volume; BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg04025307 chr7:1156635 C7orf50 0.49 8.27 0.31 8e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs9406162 chr6:8466196 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs778371 0.676 rs13024330 chr2:233715487 A/G cg08000102 chr2:233561755 GIGYF2 0.75 16.13 0.54 2.28e-49 Schizophrenia; BRCA cis rs4363385 0.510 rs6587724 chr1:153034501 T/A cg25856811 chr1:152973957 SPRR3 -0.31 -7.9 -0.3 1.23e-14 Inflammatory skin disease; BRCA cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs2276314 0.947 rs3898595 chr18:33565885 T/A cg05985134 chr18:33552581 C18orf21 0.67 12.75 0.45 2.36e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg11814155 chr7:99998594 ZCWPW1 0.49 8.72 0.33 2.48e-17 Platelet count; BRCA cis rs2033711 0.870 rs11084545 chr19:58951693 G/C cg13877915 chr19:58951672 ZNF132 0.47 11.05 0.4 4.29e-26 Uric acid clearance; BRCA cis rs1003719 0.788 rs11911508 chr21:38470504 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2204008 0.745 rs8189516 chr12:38239084 C/T cg13010199 chr12:38710504 ALG10B 0.44 8.84 0.33 9.41e-18 Bladder cancer; BRCA cis rs12368653 0.641 rs12826708 chr12:58058373 G/A cg12615879 chr12:58013172 SLC26A10 0.3 8.31 0.31 5.59e-16 Multiple sclerosis; BRCA cis rs9787249 0.957 rs2274949 chr1:40221067 G/A cg02773041 chr1:40204384 PPIE 0.45 9.71 0.36 7.12e-21 Blood protein levels; BRCA cis rs12477438 0.520 rs11123761 chr2:99705903 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.57 0.72 2.26e-105 Chronic sinus infection; BRCA cis rs2070488 0.766 rs6808093 chr3:38498160 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.64 17.28 0.56 3.5e-55 Electrocardiographic conduction measures; BRCA cis rs6598955 0.671 rs17163751 chr1:26568698 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs2882667 0.898 rs6882526 chr5:138382368 A/G cg04439458 chr5:138467593 SIL1 -0.33 -8.99 -0.33 2.85e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs8062405 1.000 rs62036624 chr16:28839930 G/T cg09719594 chr16:21412588 NA -0.33 -8.01 -0.3 5.43e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -11.94 -0.43 7.99e-30 Gut microbiome composition (summer); BRCA trans rs6076960 0.564 rs3852935 chr20:6143180 C/G cg21095983 chr6:86352623 SYNCRIP 0.36 8.49 0.32 1.41e-16 Smooth-surface caries; BRCA cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.07 0.4 3.52e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4722166 0.695 rs56061963 chr7:22800397 T/C cg05472934 chr7:22766657 IL6 0.53 13.77 0.48 5.64e-38 Lung cancer; BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg27624424 chr6:160112604 SOD2 0.38 8.31 0.31 5.96e-16 Age-related macular degeneration (geographic atrophy); BRCA cis rs6840360 0.615 rs12641438 chr4:152607586 A/G cg22705602 chr4:152727874 NA -0.38 -10.26 -0.38 5.71e-23 Intelligence (multi-trait analysis); BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg17158414 chr2:27665306 KRTCAP3 -0.35 -8.91 -0.33 5.34e-18 Menopause (age at onset); BRCA cis rs698833 0.813 rs3768919 chr2:44512971 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.54 10.57 0.39 3.43e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs6543140 0.601 rs7558013 chr2:102992806 G/T cg04239558 chr2:103089729 SLC9A4 0.33 7.9 0.3 1.23e-14 Blood protein levels; BRCA cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.91 -0.33 5.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35740288 0.929 rs11635081 chr15:86304260 G/A cg20737812 chr15:86336631 KLHL25 -0.33 -8.03 -0.3 4.54e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.38 -7.99 -0.3 6.34e-15 Longevity;Endometriosis; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg18402987 chr7:1209562 NA 0.42 8.27 0.31 7.57e-16 Longevity;Endometriosis; BRCA cis rs208520 0.874 rs208470 chr6:66916402 G/A cg07460842 chr6:66804631 NA -0.89 -15.67 -0.53 4.35e-47 Exhaled nitric oxide output; BRCA cis rs11792861 0.926 rs72607172 chr9:111876523 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.07 0.3 3.58e-15 Menarche (age at onset); BRCA cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg02297831 chr4:17616191 MED28 0.37 8.58 0.32 6.93e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9858542 0.953 rs11713474 chr3:49611457 A/G cg21659725 chr3:3221576 CRBN -0.47 -10.21 -0.37 9.35e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs250677 0.687 rs3095947 chr5:148436728 T/C cg12140854 chr5:148520817 ABLIM3 -0.42 -9.09 -0.34 1.23e-18 Breast cancer; BRCA cis rs10838687 0.736 rs7933246 chr11:47262648 G/C cg25783544 chr11:47291846 MADD 0.42 7.81 0.3 2.44e-14 Proinsulin levels; BRCA cis rs17641971 0.684 rs7819763 chr8:50030513 C/T cg00325661 chr8:49890786 NA 0.36 9.68 0.36 8.67e-21 Blood metabolite levels; BRCA cis rs10504229 0.683 rs56211106 chr8:58113497 A/G cg24829409 chr8:58192753 C8orf71 -0.47 -9.12 -0.34 9.38e-19 Developmental language disorder (linguistic errors); BRCA cis rs9296092 0.560 rs7765263 chr6:33525559 A/G cg13560919 chr6:33536144 NA -0.85 -18.96 -0.6 5.84e-64 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs6963495 0.818 rs117907809 chr7:105168472 C/A cg19920283 chr7:105172520 RINT1 0.59 9.47 0.35 5.25e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg03264133 chr6:25882463 NA -0.42 -9.18 -0.34 5.95e-19 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs35915560 chr4:98978649 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 3.08e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9291683 0.526 rs12506122 chr4:10033538 C/A cg00071950 chr4:10020882 SLC2A9 0.56 13.53 0.47 7.59e-37 Bone mineral density; BRCA cis rs17253792 0.822 rs10137885 chr14:56173590 A/G cg01858014 chr14:56050164 KTN1 -0.6 -9.1 -0.34 1.17e-18 Putamen volume; BRCA trans rs61931739 0.517 rs860950 chr12:34104376 C/G cg26384229 chr12:38710491 ALG10B 0.57 12.26 0.44 3.38e-31 Morning vs. evening chronotype; BRCA cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg21951975 chr1:209979733 IRF6 0.39 8.95 0.33 3.75e-18 Cleft lip with or without cleft palate; BRCA cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.31 9.88 0.36 1.58e-21 Electroencephalogram traits; BRCA cis rs6028335 0.610 rs6729 chr20:37668272 A/G cg16355469 chr20:37678765 NA 0.5 8.82 0.33 1.06e-17 Alcohol and nicotine co-dependence; BRCA cis rs9381040 0.655 rs9381031 chr6:41044957 A/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg09256448 chr16:638327 NA 0.3 7.96 0.3 7.8e-15 Height; BRCA cis rs6867032 0.527 rs9312971 chr5:2012888 C/A cg26168224 chr5:2018326 NA 0.46 12.42 0.44 7.11e-32 Gut microbiome composition (winter); BRCA cis rs2070488 0.965 rs13079145 chr3:38517992 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.36 0.63 2.22e-71 Electrocardiographic conduction measures; BRCA cis rs311392 0.967 rs4463399 chr8:55089449 T/C cg11783602 chr8:55087084 NA -0.32 -9.49 -0.35 4.38e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs757081 0.667 rs17473243 chr11:17266259 G/A cg15432903 chr11:17409602 KCNJ11 -0.46 -8.68 -0.32 3.37e-17 Systolic blood pressure; BRCA cis rs7394190 0.630 rs113799665 chr10:75575138 C/T cg07699608 chr10:75541558 CHCHD1 0.67 9.77 0.36 4.05e-21 Incident atrial fibrillation; BRCA cis rs1448094 0.549 rs12308898 chr12:86233678 G/A cg02569458 chr12:86230093 RASSF9 0.32 8.02 0.3 5.07e-15 Major depressive disorder; BRCA cis rs1801251 1.000 rs895430 chr2:233725483 C/A cg25237894 chr2:233734115 C2orf82 -0.41 -11.75 -0.42 5.12e-29 Coronary artery disease; BRCA cis rs35110281 0.667 rs914197 chr21:45117439 A/G cg04455712 chr21:45112962 RRP1B 0.43 11.25 0.41 6.33e-27 Mean corpuscular volume; BRCA cis rs2115630 1.000 rs11854291 chr15:85363708 T/C cg12863693 chr15:85201151 NMB -0.36 -8.5 -0.32 1.34e-16 P wave terminal force; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg21280719 chr6:42927975 GNMT -0.31 -12.93 -0.46 3.77e-34 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7613875 0.600 rs2247510 chr3:50126215 A/C cg14019146 chr3:50243930 SLC38A3 -0.36 -8.88 -0.33 6.57e-18 Body mass index; BRCA cis rs12220238 1.000 rs12256105 chr10:75909634 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.5 8.09 0.3 3.05e-15 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs4566357 0.615 rs2894626 chr2:227916039 T/C cg05526886 chr2:227700861 RHBDD1 -0.4 -8.26 -0.31 8.56e-16 Coronary artery disease; BRCA cis rs7605378 0.528 rs281780 chr2:200756331 G/C cg23649088 chr2:200775458 C2orf69 0.72 16.2 0.54 1.1e-49 Osteoporosis; BRCA cis rs6088580 0.634 rs4911423 chr20:32999386 T/A cg08999081 chr20:33150536 PIGU -0.46 -12.77 -0.45 2.05e-33 Glomerular filtration rate (creatinine); BRCA cis rs6598955 0.543 rs6698557 chr1:26561220 G/C cg04990556 chr1:26633338 UBXN11 0.69 12.0 0.43 4.75e-30 Obesity-related traits; BRCA cis rs9287719 0.967 rs6748036 chr2:10717489 C/T cg02196655 chr2:10830764 NOL10 -0.29 -7.91 -0.3 1.16e-14 Prostate cancer; BRCA cis rs6598955 0.585 rs6659822 chr1:26626408 C/A cg04990556 chr1:26633338 UBXN11 0.54 9.11 0.34 1.04e-18 Obesity-related traits; BRCA cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg24531977 chr5:56204891 C5orf35 -0.86 -17.48 -0.57 3.46e-56 Initial pursuit acceleration; BRCA cis rs2204008 0.660 rs2320745 chr12:38239101 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.35 0.31 4.19e-16 Bladder cancer; BRCA cis rs2425143 1.000 rs11699044 chr20:34312713 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.64 10.32 0.38 3.42e-23 Blood protein levels; BRCA trans rs2197308 0.655 rs1971964 chr12:37870474 C/T cg06521331 chr12:34319734 NA -0.54 -9.75 -0.36 5.06e-21 Morning vs. evening chronotype; BRCA cis rs3740540 0.530 rs2362503 chr10:126290538 T/C cg04949429 chr10:126290192 LHPP 0.43 12.12 0.43 1.46e-30 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs2404602 0.735 rs2454450 chr15:76831236 G/A cg23625390 chr15:77176239 SCAPER -0.52 -12.79 -0.45 1.69e-33 Blood metabolite levels; BRCA cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10754283 0.967 rs7513928 chr1:90104834 A/G cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs3733585 0.654 rs4447863 chr4:9938969 T/C cg11266682 chr4:10021025 SLC2A9 -0.42 -11.1 -0.4 2.61e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs250677 0.522 rs55732303 chr5:148392538 C/T cg18129178 chr5:148520854 ABLIM3 -0.55 -10.56 -0.39 3.95e-24 Breast cancer; BRCA cis rs9287719 0.967 rs6432120 chr2:10753771 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs703842 1.000 rs10877015 chr12:58167788 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.44 0.44 5.91e-32 Multiple sclerosis; BRCA cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.43 -0.35 7.75e-20 Developmental language disorder (linguistic errors); BRCA cis rs9287719 0.967 rs7593496 chr2:10738176 A/C cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs1550582 1.000 rs7822348 chr8:135542483 C/G cg17885191 chr8:135476712 NA 0.63 11.38 0.41 1.91e-27 Educational attainment; BRCA cis rs7666738 0.830 rs13102369 chr4:99045912 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs881375 0.967 rs10435844 chr9:123668199 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.53 0.32 1.09e-16 Rheumatoid arthritis; BRCA cis rs78456975 0.506 rs6756310 chr2:1549809 A/G cg26248373 chr2:1572462 NA -0.53 -11.61 -0.42 1.98e-28 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7072216 0.763 rs4475861 chr10:100164989 C/T cg26618903 chr10:100175079 PYROXD2 -0.27 -7.95 -0.3 8.27e-15 Metabolite levels; BRCA cis rs1707322 0.682 rs12041197 chr1:46104464 T/C cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.58e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1499972 0.887 rs817504 chr3:117678862 A/C cg07612923 chr3:117604196 NA -0.6 -8.25 -0.31 9.26e-16 Schizophrenia; BRCA cis rs2836950 0.501 rs2836985 chr21:40701169 A/G cg11890956 chr21:40555474 PSMG1 -0.61 -13.36 -0.47 4.64e-36 Menarche (age at onset); BRCA cis rs317689 0.876 rs547332 chr12:69743639 C/G cg20891283 chr12:69753455 YEATS4 0.6 13.8 0.48 4.32e-38 Response to diuretic therapy; BRCA cis rs1552244 0.935 rs7618815 chr3:10151045 A/G cg13047869 chr3:10149882 C3orf24 0.6 12.81 0.45 1.29e-33 Alzheimer's disease; BRCA cis rs1635 0.655 rs73742539 chr6:28305471 C/T cg15743358 chr6:28303923 ZNF323 -0.75 -8.75 -0.33 1.94e-17 Schizophrenia; BRCA cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg00106254 chr7:1943704 MAD1L1 -0.37 -8.98 -0.33 3e-18 Bipolar disorder and schizophrenia; BRCA cis rs9487051 1.000 rs9386796 chr6:109618704 C/T cg12927641 chr6:109611667 NA -0.36 -8.92 -0.33 4.89e-18 Reticulocyte fraction of red cells; BRCA cis rs243505 1.000 rs1019059 chr7:148424247 A/G cg09806900 chr7:148480153 CUL1 -0.43 -8.81 -0.33 1.15e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs919433 1.000 rs2195510 chr2:198161195 A/G cg03934865 chr2:198174659 NA -0.39 -8.39 -0.32 3.09e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs146671954 1 rs146671954 chr9:136934203 G/A cg09836344 chr4:1243392 C4orf42;CTBP1 -0.68 -9.86 -0.36 1.93e-21 Red cell distribution width; BRCA cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg03213289 chr20:61660250 NA 0.61 16.19 0.54 1.21e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088580 0.634 rs6059878 chr20:33087166 A/T cg24642439 chr20:33292090 TP53INP2 0.53 11.6 0.42 2.23e-28 Glomerular filtration rate (creatinine); BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 21.09 0.64 2.41e-75 Platelet count; BRCA cis rs1065656 0.571 rs12149777 chr16:1834724 A/G cg09540102 chr16:1822124 NME3;MRPS34;EME2 -0.35 -8.27 -0.31 7.69e-16 Insulin-like growth factors; BRCA cis rs3806843 0.735 rs801185 chr5:140068869 A/G cg26395211 chr5:140044315 WDR55 0.37 8.55 0.32 9.02e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs66725070 1 rs66725070 chr15:58267416 GACAT/G cg12031962 chr15:58353849 ALDH1A2 -0.5 -13.22 -0.46 2.02e-35 Barrett's esophagus; BRCA cis rs3862030 0.668 rs12781718 chr10:104227433 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.13 -0.43 1.25e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs7044106 0.762 rs1547268 chr9:123408688 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.83 0.42 2.47e-29 Hip circumference adjusted for BMI; BRCA cis rs4965272 1.000 rs1585932 chr15:100585637 A/C cg27344315 chr15:100560801 ADAMTS17 -0.38 -8.01 -0.3 5.4e-15 Gastroesophageal reflux disease; BRCA cis rs4595586 0.563 rs11169769 chr12:39233134 C/G cg13010199 chr12:38710504 ALG10B 0.44 8.6 0.32 6.39e-17 Morning vs. evening chronotype; BRCA cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg13628971 chr7:2884303 GNA12 0.38 8.49 0.32 1.44e-16 Height; BRCA cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24308560 chr3:49941425 MST1R -0.4 -8.61 -0.32 5.78e-17 Intelligence (multi-trait analysis); BRCA cis rs1113500 0.933 rs4593854 chr1:108638519 A/G cg06207961 chr1:108661230 NA 0.44 10.66 0.39 1.58e-24 Growth-regulated protein alpha levels; BRCA cis rs5753037 0.653 rs140129 chr22:30150549 C/T cg01021169 chr22:30184971 ASCC2 -0.34 -8.09 -0.3 3.08e-15 Type 1 diabetes; BRCA cis rs9287719 0.839 rs7600695 chr2:10739945 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA trans rs6952808 0.582 rs10479762 chr7:2045351 T/C cg04565464 chr8:145669602 NFKBIL2 -0.37 -9.33 -0.35 1.66e-19 Bipolar disorder and schizophrenia; BRCA cis rs12760731 0.720 rs10913553 chr1:178423062 G/C cg00404053 chr1:178313656 RASAL2 0.61 7.99 0.3 6.33e-15 Obesity-related traits; BRCA trans rs2018683 0.770 rs10951208 chr7:29022504 G/T cg19402173 chr7:128379420 CALU -0.47 -11.3 -0.41 4.07e-27 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs7927592 0.913 rs7107622 chr11:68374183 T/C cg20283391 chr11:68216788 NA -0.45 -9.36 -0.35 1.29e-19 Total body bone mineral density; BRCA trans rs2204008 0.775 rs11514370 chr12:38305566 G/A cg06521331 chr12:34319734 NA -0.45 -8.56 -0.32 8.24e-17 Bladder cancer; BRCA cis rs1355223 0.545 rs7111695 chr11:34874906 T/G cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6973256 0.583 rs2430768 chr7:133340287 T/C cg07491979 chr7:133331646 EXOC4 -0.35 -8.13 -0.31 2.28e-15 Intelligence (multi-trait analysis); BRCA cis rs826838 0.967 rs11169142 chr12:39085773 A/T cg26384229 chr12:38710491 ALG10B -0.62 -16.07 -0.54 4.8e-49 Heart rate; BRCA cis rs10267417 0.603 rs10260797 chr7:19890181 A/G cg07541023 chr7:19748670 TWISTNB 0.47 8.58 0.32 7.44e-17 Night sleep phenotypes; BRCA cis rs2991971 0.933 rs666720 chr1:46020795 T/C cg15605315 chr1:45957053 TESK2 0.45 9.26 0.34 3.1e-19 High light scatter reticulocyte count; BRCA cis rs2836633 0.895 rs2836597 chr21:40024424 A/G cg05519781 chr21:40033154 ERG 0.43 9.65 0.36 1.16e-20 Coronary artery disease; BRCA cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 10.98 0.4 8.08e-26 Rheumatoid arthritis; BRCA trans rs9858542 0.953 rs11719996 chr3:49525958 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.66 -0.36 1.04e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs60843830 1.000 rs60484953 chr2:221560 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.24 0.59 3.53e-60 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs8180040 0.620 rs11917361 chr3:47070497 G/T cg27129171 chr3:47204927 SETD2 -0.72 -17.91 -0.58 1.9e-58 Colorectal cancer; BRCA cis rs1003719 0.788 rs4817843 chr21:38447040 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.25 0.49 3.17e-40 Eye color traits; BRCA cis rs9463078 0.764 rs3846896 chr6:44834094 G/A cg25276700 chr6:44698697 NA -0.35 -8.12 -0.31 2.37e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4803468 1.000 rs284651 chr19:41928336 T/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.03 -0.67 6.56e-86 Height; BRCA cis rs2559856 1.000 rs2695286 chr12:102088507 T/C cg12924262 chr12:102091054 CHPT1 0.38 8.57 0.32 7.9e-17 Blood protein levels; BRCA cis rs7809950 0.817 rs4727679 chr7:107085018 T/C cg23024343 chr7:107201750 COG5 -0.5 -10.49 -0.38 7.39e-24 Coronary artery disease; BRCA cis rs17376456 0.778 rs72786662 chr5:93137630 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.33 0.59 1.34e-60 Diabetic retinopathy; BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg11843238 chr5:131593191 PDLIM4 0.35 9.1 0.34 1.1e-18 Breast cancer; BRCA cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg15395560 chr15:45543142 SLC28A2 -0.29 -7.83 -0.3 2.02e-14 Uric acid levels; BRCA cis rs7944584 0.655 rs2856653 chr11:47361084 T/C cg20307385 chr11:47447363 PSMC3 -0.51 -11.26 -0.41 6.05e-27 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs7613875 0.620 rs34312088 chr3:50032133 C/T cg05623727 chr3:50126028 RBM5 0.5 12.18 0.43 7.94e-31 Body mass index; BRCA cis rs3806843 0.766 rs801176 chr5:140087010 A/G cg26395211 chr5:140044315 WDR55 -0.35 -8.02 -0.3 5.09e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7301826 0.560 rs12829294 chr12:131309972 A/G cg11011512 chr12:131303247 STX2 -0.44 -11.03 -0.4 4.9e-26 Plasma plasminogen activator levels; BRCA trans rs4332037 0.539 rs55993248 chr7:2071132 A/G cg25206134 chr2:45395956 NA 0.51 8.77 0.33 1.65e-17 Bipolar disorder; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg04518342 chr5:131593106 PDLIM4 0.37 8.69 0.33 3.09e-17 Acylcarnitine levels; BRCA cis rs2742234 0.541 rs1059484 chr10:43679800 T/G cg02780029 chr10:43622663 RET -0.35 -7.96 -0.3 7.97e-15 Hirschsprung disease; BRCA cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg01017244 chr2:74357527 NA 0.66 12.91 0.45 4.66e-34 Gestational age at birth (maternal effect); BRCA cis rs2625529 0.652 rs2957734 chr15:72261385 A/G cg16672083 chr15:72433130 SENP8 0.68 16.19 0.54 1.14e-49 Red blood cell count; BRCA cis rs1707322 1.000 rs7547284 chr1:46319565 C/G cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.13e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs220324 0.688 rs915840 chr21:43560871 T/C cg09727148 chr21:43560719 UMODL1 0.5 8.85 0.33 8.23e-18 Idiopathic osteonecrosis of the femoral head; BRCA trans rs61931739 0.500 rs7955933 chr12:34473608 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.05e-18 Morning vs. evening chronotype; BRCA cis rs9325144 0.555 rs6582607 chr12:38717678 T/C cg26384229 chr12:38710491 ALG10B -0.53 -12.76 -0.45 2.2e-33 Morning vs. evening chronotype; BRCA cis rs2624839 0.704 rs13064381 chr3:50233317 C/T cg05623727 chr3:50126028 RBM5 0.38 8.02 0.3 5.12e-15 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.934 rs9290074 chr3:160997823 T/C cg03342759 chr3:160939853 NMD3 -0.63 -13.25 -0.46 1.38e-35 Morning vs. evening chronotype; BRCA cis rs12477438 0.520 rs2632276 chr2:99779655 C/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.27 0.73 3.24e-109 Chronic sinus infection; BRCA cis rs694739 0.726 rs516124 chr11:64128423 G/T cg02228329 chr11:64053129 BAD;GPR137 0.53 11.69 0.42 9.94e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.42 -9.53 -0.35 3.28e-20 Electroencephalogram traits; BRCA cis rs7914558 0.966 rs10786721 chr10:104654383 C/A cg04362960 chr10:104952993 NT5C2 0.42 10.14 0.37 1.67e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg17971929 chr21:40555470 PSMG1 0.78 18.44 0.59 3.54e-61 Cognitive function; BRCA trans rs35110281 0.805 rs2838317 chr21:44991791 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.48 0.32 1.5e-16 Mean corpuscular volume; BRCA cis rs921968 0.541 rs3755042 chr2:219317248 T/C cg02176678 chr2:219576539 TTLL4 -0.51 -13.15 -0.46 3.95e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs9837602 0.872 rs4928234 chr3:99704861 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -11.28 -0.41 4.85e-27 Breast cancer; BRCA trans rs2018683 0.707 rs1021689 chr7:28974223 G/T cg19402173 chr7:128379420 CALU -0.42 -9.93 -0.37 1e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6964587 0.626 rs34404183 chr7:91551249 T/C cg17063962 chr7:91808500 NA -0.56 -12.82 -0.45 1.23e-33 Breast cancer; BRCA cis rs897080 0.515 rs1085444 chr2:44624155 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.34 0.35 1.53e-19 Height; BRCA cis rs6973256 0.897 rs2345941 chr7:133337635 C/T cg07491979 chr7:133331646 EXOC4 0.38 8.61 0.32 5.84e-17 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.714 rs2282526 chr21:45080552 A/T cg21573476 chr21:45109991 RRP1B -0.37 -9.28 -0.34 2.58e-19 Mean corpuscular volume; BRCA trans rs6089829 0.962 rs6062393 chr20:61663230 G/A cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg26608667 chr7:1196370 ZFAND2A 0.45 10.71 0.39 9.62e-25 Longevity;Endometriosis; BRCA cis rs13046373 0.505 rs2832962 chr21:32008332 T/C cg16812893 chr21:31813075 KRTAP15-1 0.38 9.5 0.35 4.26e-20 HDL cholesterol; BRCA cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg19077165 chr18:44547161 KATNAL2 0.55 12.14 0.43 1.1e-30 Personality dimensions; BRCA cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg24549020 chr5:56110836 MAP3K1 0.6 12.38 0.44 1.05e-31 Initial pursuit acceleration; BRCA cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg00631329 chr6:26305371 NA -0.45 -13.64 -0.47 2.41e-37 Educational attainment; BRCA cis rs2289583 0.573 rs12148555 chr15:75395475 C/T cg14664628 chr15:75095509 CSK 0.39 9.08 0.34 1.31e-18 Systemic lupus erythematosus; BRCA cis rs7178424 0.935 rs8034335 chr15:62287456 A/G cg00456672 chr15:62358751 C2CD4A 0.42 9.68 0.36 9.05e-21 Height; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg26608667 chr7:1196370 ZFAND2A 0.41 9.0 0.34 2.47e-18 Longevity;Endometriosis; BRCA cis rs9486719 0.843 rs2205754 chr6:96843134 T/C cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg12311346 chr5:56204834 C5orf35 0.61 12.61 0.45 9.85e-33 Initial pursuit acceleration; BRCA cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg20701182 chr2:24300061 SF3B14 0.55 8.52 0.32 1.15e-16 Lymphocyte counts; BRCA cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg01689657 chr7:91764605 CYP51A1 0.24 8.61 0.32 5.86e-17 Breast cancer; BRCA cis rs3099143 1.000 rs3106380 chr15:77104377 G/A cg21673338 chr15:77095150 SCAPER -0.53 -9.4 -0.35 9.79e-20 Recalcitrant atopic dermatitis; BRCA cis rs2243480 1.000 rs313803 chr7:65514731 G/A cg18252515 chr7:66147081 NA -0.97 -13.79 -0.48 4.42e-38 Diabetic kidney disease; BRCA cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg07606381 chr6:8435919 SLC35B3 0.65 14.41 0.5 5.45e-41 Motion sickness; BRCA cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg08213375 chr14:104286397 PPP1R13B 0.65 18.38 0.59 6.72e-61 Schizophrenia; BRCA cis rs2625529 0.590 rs8023703 chr15:72504059 G/A cg16672083 chr15:72433130 SENP8 0.71 15.67 0.53 4.45e-47 Red blood cell count; BRCA cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg22972055 chr7:872293 UNC84A 0.38 8.46 0.32 1.83e-16 Cerebrospinal P-tau181p levels; BRCA trans rs6952808 0.575 rs6950330 chr7:1953606 T/C cg04565464 chr8:145669602 NFKBIL2 0.35 8.72 0.33 2.48e-17 Bipolar disorder and schizophrenia; BRCA cis rs1018836 0.923 rs7837230 chr8:91574281 C/T cg16814680 chr8:91681699 NA -0.58 -12.53 -0.44 2.4e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 0.863 rs13140391 chr4:120503437 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.45 0.32 1.97e-16 Corneal astigmatism; BRCA cis rs651907 0.557 rs13069443 chr3:101373305 C/T cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.93 -0.3 1.01e-14 Colorectal cancer; BRCA cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg07952391 chr2:88470173 THNSL2 -0.64 -8.65 -0.32 4.24e-17 Plasma clusterin levels; BRCA cis rs11229555 0.645 rs36019763 chr11:58232283 G/T cg15696309 chr11:58395628 NA -0.52 -10.85 -0.39 2.81e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9733 0.744 rs2089081 chr1:150800117 T/C cg13175981 chr1:150552382 MCL1 0.41 9.16 0.34 7.18e-19 Tonsillectomy; BRCA cis rs7572733 0.515 rs11891555 chr2:198853540 G/T cg00792783 chr2:198669748 PLCL1 0.44 9.53 0.35 3.28e-20 Dermatomyositis; BRCA cis rs7246657 0.943 rs713256 chr19:37865365 C/T cg18154014 chr19:37997991 ZNF793 0.59 11.15 0.4 1.72e-26 Coronary artery calcification; BRCA cis rs4302748 0.862 rs11973172 chr7:36183435 A/T cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs7267979 0.903 rs6050481 chr20:25224580 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.43 0.32 2.37e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2251381 0.778 rs2245021 chr21:30546841 C/T cg08807101 chr21:30365312 RNF160 0.56 12.19 0.43 7.01e-31 Selective IgA deficiency; BRCA cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs4481887 0.927 rs4564179 chr1:248472422 T/C cg00666640 chr1:248458726 OR2T12 0.29 8.25 0.31 8.85e-16 Common traits (Other); BRCA trans rs7395662 0.571 rs12421145 chr11:48624725 C/A cg00717180 chr2:96193071 NA -0.38 -10.34 -0.38 2.9e-23 HDL cholesterol; BRCA cis rs754466 0.606 rs12356375 chr10:79594514 C/A cg17075019 chr10:79541650 NA -0.81 -21.2 -0.64 5.98e-76 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs9291683 0.620 rs7699512 chr4:10125808 C/T cg26043149 chr18:55253948 FECH -0.4 -8.77 -0.33 1.66e-17 Bone mineral density; BRCA cis rs12824058 0.831 rs1390849 chr12:130811547 A/G cg24838063 chr12:130822603 PIWIL1 0.68 16.73 0.55 2.13e-52 Menopause (age at onset); BRCA cis rs881375 0.902 rs2900180 chr9:123706382 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.27 0.31 7.75e-16 Rheumatoid arthritis; BRCA cis rs2806561 0.929 rs6669568 chr1:23540469 G/A cg19743168 chr1:23544995 NA -0.47 -11.79 -0.42 3.53e-29 Height; BRCA cis rs10129255 0.500 rs988134 chr14:107184937 A/G cg07958169 chr14:107095056 NA -0.4 -8.62 -0.32 5.2e-17 Kawasaki disease; BRCA cis rs6088590 0.502 rs6059861 chr20:33068563 A/T cg24642439 chr20:33292090 TP53INP2 0.53 11.5 0.41 5.99e-28 Coronary artery disease; BRCA cis rs9318086 0.712 rs3794339 chr13:24434065 A/C cg25267304 chr13:24462978 PCOTH;MIPEP 0.33 9.47 0.35 5.25e-20 Myopia (pathological); BRCA cis rs1595825 0.836 rs79748557 chr2:198567912 G/T cg19156104 chr2:198669113 PLCL1 -0.43 -7.89 -0.3 1.29e-14 Ulcerative colitis; BRCA cis rs873946 0.648 rs12767126 chr10:134556992 C/T cg06453172 chr10:134556979 INPP5A -0.6 -11.77 -0.42 4.54e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs12368653 0.666 rs1050045 chr12:58115271 A/G cg18357645 chr12:58087776 OS9 0.34 9.79 0.36 3.42e-21 Multiple sclerosis; BRCA cis rs921968 0.565 rs7586384 chr2:219582897 T/C cg02176678 chr2:219576539 TTLL4 -0.42 -11.05 -0.4 4.09e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs6570726 0.935 rs371744 chr6:145841024 C/T cg23711669 chr6:146136114 FBXO30 0.65 15.41 0.52 8.91e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs17092148 0.887 rs6058077 chr20:33140999 G/A cg16810054 chr20:33298113 TP53INP2 -0.46 -10.24 -0.38 6.71e-23 Neuroticism; BRCA cis rs11098499 0.708 rs1546506 chr4:120241240 T/C cg09307838 chr4:120376055 NA 0.63 13.82 0.48 3.28e-38 Corneal astigmatism; BRCA cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg08392591 chr16:89556376 ANKRD11 -0.36 -8.15 -0.31 1.95e-15 Multiple myeloma (IgH translocation); BRCA cis rs9296092 0.517 rs76361685 chr6:33536458 G/C cg13560919 chr6:33536144 NA -0.91 -19.2 -0.6 3.31e-65 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs10504229 1.000 rs67236942 chr8:58176525 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9467711 0.591 rs68149500 chr6:26111271 C/T cg21479132 chr6:26055353 NA 0.6 8.1 0.31 2.72e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs11229555 0.645 rs7926682 chr11:58189495 A/G cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7121446 0.521 rs12293988 chr11:121852633 C/T cg13820391 chr11:121835505 NA 0.29 8.05 0.3 3.98e-15 Cardiovascular risk factors (age interaction); BRCA cis rs6782228 0.651 rs9852825 chr3:128387357 C/G cg16766828 chr3:128327626 NA -0.43 -9.49 -0.35 4.68e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7560272 0.538 rs12619258 chr2:73935915 G/T cg20560298 chr2:73613845 ALMS1 0.35 8.86 0.33 7.97e-18 Schizophrenia; BRCA trans rs62103177 0.810 rs62103178 chr18:77624555 C/G cg05926928 chr17:57297772 GDPD1 1.17 15.84 0.53 6.24e-48 Opioid sensitivity; BRCA cis rs35306767 0.761 rs12359796 chr10:1021479 G/C cg18964960 chr10:1102726 WDR37 0.61 8.07 0.3 3.53e-15 Eosinophil percentage of granulocytes; BRCA cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg11266682 chr4:10021025 SLC2A9 0.48 12.72 0.45 3.27e-33 Bone mineral density; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg26314531 chr2:26401878 FAM59B -0.86 -14.57 -0.5 9.9e-42 Gut microbiome composition (summer); BRCA cis rs701145 0.585 rs2060622 chr3:153833862 A/T cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.2e-14 Coronary artery disease; BRCA cis rs897984 0.609 rs35468353 chr16:31056433 A/G cg00531865 chr16:30841666 NA -0.38 -9.06 -0.34 1.62e-18 Dementia with Lewy bodies; BRCA cis rs769267 0.895 rs2916074 chr19:19530270 C/T cg01262667 chr19:19385393 TM6SF2 0.4 10.44 0.38 1.13e-23 Tonsillectomy; BRCA cis rs12586317 0.547 rs10145723 chr14:35460954 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.28 -0.38 4.75e-23 Psoriasis; BRCA cis rs910316 1.000 rs175436 chr14:75608683 C/G cg23033748 chr14:75592666 NEK9 -0.43 -10.47 -0.38 9.17e-24 Height; BRCA trans rs7618501 0.669 rs7634084 chr3:49949834 A/T cg21659725 chr3:3221576 CRBN 0.47 11.79 0.42 3.65e-29 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg10802521 chr3:52805072 NEK4 0.32 8.03 0.3 4.79e-15 Bipolar disorder; BRCA cis rs3806843 1.000 rs10066278 chr5:140156318 A/C cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.48 -0.35 4.98e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs13046373 0.535 rs1961167 chr21:32030310 T/C cg16431978 chr21:31797932 KRTAP13-3 0.35 8.7 0.33 2.81e-17 HDL cholesterol; BRCA cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg00012203 chr2:219082015 ARPC2 -0.5 -9.98 -0.37 7.02e-22 Colorectal cancer; BRCA cis rs933688 1.000 rs10058025 chr5:90689052 A/G cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.9 19.33 0.61 6.67e-66 Smoking behavior; BRCA cis rs6820391 0.816 rs1002824 chr4:54445980 A/C cg04173182 chr4:54446035 LNX1 -0.53 -11.54 -0.42 3.91e-28 Cervical artery dissection; BRCA cis rs12142240 0.698 rs9661240 chr1:46827050 G/A cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs4595586 0.545 rs1303886 chr12:39366876 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs149866169 1 rs149866169 chr6:27441723 T/A cg26587870 chr6:27730563 NA -0.71 -9.58 -0.35 2.11e-20 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; BRCA cis rs735396 0.627 rs2264778 chr12:121450354 C/A cg02403541 chr12:121454288 C12orf43 0.7 15.06 0.51 4.5e-44 N-glycan levels; BRCA cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 8.45 0.32 1.97e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.590 rs1368902 chr2:26440576 T/C cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs2841233 0.681 rs2582558 chr14:105347488 A/G cg16576083 chr14:105354267 KIAA0284 -0.45 -11.7 -0.42 8.77e-29 IgG glycosylation; BRCA cis rs6701037 0.522 rs7521981 chr1:175091151 C/T cg00321850 chr1:175162397 KIAA0040 -0.31 -8.04 -0.3 4.43e-15 Alcohol dependence; BRCA cis rs7647973 0.626 rs1463728 chr3:49647404 T/A cg03060546 chr3:49711283 APEH 0.55 9.21 0.34 4.6e-19 Menarche (age at onset); BRCA cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg23029597 chr12:123009494 RSRC2 0.59 12.44 0.44 5.58e-32 Body mass index; BRCA cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 11.46 0.41 8.82e-28 Mean platelet volume; BRCA cis rs7903847 0.642 rs11189174 chr10:99139600 C/G cg20016023 chr10:99160130 RRP12 -0.27 -8.64 -0.32 4.4e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.45 0.35 6.39e-20 Motion sickness; BRCA cis rs12950390 1.000 rs12950390 chr17:45830948 A/G cg03474202 chr17:45855739 NA -0.4 -9.14 -0.34 8.39e-19 IgG glycosylation; BRCA cis rs7737355 0.947 rs6895841 chr5:130773534 A/G cg06307176 chr5:131281290 NA 0.53 10.39 0.38 1.87e-23 Life satisfaction; BRCA trans rs6089829 0.962 rs3746749 chr20:61667333 T/C cg15934090 chr1:100435551 SLC35A3 0.35 8.17 0.31 1.72e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10193935 0.901 rs12615383 chr2:42610551 A/G cg27598129 chr2:42591480 NA 0.9 14.74 0.5 1.51e-42 Colonoscopy-negative controls vs population controls; BRCA trans rs561341 1.000 rs501312 chr17:30329066 A/G cg20587970 chr11:113659929 NA -1.24 -22.71 -0.67 3.66e-84 Hip circumference adjusted for BMI; BRCA cis rs2131877 0.529 rs7644208 chr3:194855954 G/A cg13868855 chr3:194833887 C3orf21 -0.34 -8.1 -0.31 2.75e-15 Non-small cell lung cancer; BRCA cis rs35110281 0.627 rs1436291 chr21:44965485 T/C cg04455712 chr21:45112962 RRP1B 0.38 9.85 0.36 2.03e-21 Mean corpuscular volume; BRCA cis rs7631605 0.935 rs3774341 chr3:37045233 A/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.6 0.35 1.79e-20 Cerebrospinal P-tau181p levels; BRCA cis rs17095355 1.000 rs975442 chr10:111705895 A/G cg00817464 chr10:111662876 XPNPEP1 -0.37 -9.43 -0.35 7.62e-20 Biliary atresia; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg22903471 chr2:27725779 GCKR -0.37 -9.05 -0.34 1.77e-18 Total body bone mineral density; BRCA cis rs921968 0.565 rs35358516 chr2:219625723 A/C cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.71e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs77956314 0.515 rs12299065 chr12:117442304 A/G cg02017074 chr12:117425053 FBXW8 0.59 10.84 0.39 3.01e-25 Subcortical brain region volumes;Hippocampal volume; BRCA trans rs2204008 0.805 rs11514348 chr12:38243427 T/C cg06521331 chr12:34319734 NA -0.53 -9.55 -0.35 2.78e-20 Bladder cancer; BRCA cis rs1008375 0.932 rs10009933 chr4:17670107 A/C cg15017067 chr4:17643749 FAM184B 0.29 8.58 0.32 7.09e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs72781680 0.821 rs72796325 chr2:24134537 G/A cg08917208 chr2:24149416 ATAD2B 0.63 10.71 0.39 9.66e-25 Lymphocyte counts; BRCA trans rs11039571 0.588 rs61917001 chr11:48233667 G/C cg15704280 chr7:45808275 SEPT13 0.54 8.89 0.33 6.21e-18 D-dimer levels; BRCA cis rs4887140 0.717 rs8040531 chr15:74052205 A/G cg11789681 chr15:74046708 NA 0.52 8.09 0.3 3.08e-15 Glucose homeostasis traits; BRCA cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.32 0.49 1.55e-40 Motion sickness; BRCA cis rs10492096 1.000 rs10849462 chr12:6575992 C/T cg13857086 chr12:6580257 VAMP1 0.44 8.57 0.32 8.03e-17 Hip geometry; BRCA cis rs17401966 0.931 rs11587854 chr1:10447622 G/A cg03954927 chr1:10346856 KIF1B 0.48 14.58 0.5 9.03e-42 Hepatocellular carcinoma; BRCA cis rs72781680 0.898 rs72788218 chr2:24090435 C/T cg08917208 chr2:24149416 ATAD2B 0.78 12.2 0.43 6.41e-31 Lymphocyte counts; BRCA cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg02297831 chr4:17616191 MED28 0.37 8.52 0.32 1.13e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg25427524 chr10:38739819 LOC399744 -0.74 -18.29 -0.59 1.97e-60 Extrinsic epigenetic age acceleration; BRCA cis rs243505 0.898 rs243524 chr7:148418181 A/C cg09806900 chr7:148480153 CUL1 -0.39 -7.95 -0.3 8.21e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13031619 0.607 rs13001751 chr2:3695870 A/G cg19052272 chr2:3704530 ALLC -0.38 -8.9 -0.33 5.82e-18 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2404602 0.716 rs12917430 chr15:76674360 T/C cg22467129 chr15:76604101 ETFA -0.48 -10.77 -0.39 5.46e-25 Blood metabolite levels; BRCA cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg24558204 chr6:135376177 HBS1L 0.53 14.75 0.5 1.34e-42 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs798554 0.660 rs798480 chr7:2805597 G/T cg13628971 chr7:2884303 GNA12 0.37 7.94 0.3 8.96e-15 Height; BRCA cis rs7116495 0.609 rs2503 chr11:71719403 C/T cg10381502 chr11:71823885 C11orf51 0.93 9.5 0.35 4.19e-20 Severe influenza A (H1N1) infection; BRCA cis rs2797160 0.967 rs1739358 chr6:126019736 G/A cg05901451 chr6:126070800 HEY2 0.4 9.77 0.36 4.03e-21 Endometrial cancer; BRCA cis rs17401966 1.000 rs35837142 chr1:10322358 C/G cg03954927 chr1:10346856 KIF1B 0.46 12.9 0.45 5.43e-34 Hepatocellular carcinoma; BRCA cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.0 0.4 6.57e-26 Bipolar disorder; BRCA cis rs10751667 0.600 rs10751672 chr11:948712 T/C ch.11.42038R chr11:967971 AP2A2 0.5 15.89 0.53 3.66e-48 Alzheimer's disease (late onset); BRCA cis rs9311474 0.607 rs11711421 chr3:52561779 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 8.44 0.32 2.04e-16 Electroencephalogram traits; BRCA cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.17 -0.37 1.24e-22 Initial pursuit acceleration; BRCA cis rs1003719 0.788 rs7276917 chr21:38451334 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.23e-40 Eye color traits; BRCA cis rs796364 0.951 rs11680258 chr2:200996976 T/C cg23649088 chr2:200775458 C2orf69 -0.62 -10.37 -0.38 2.23e-23 Schizophrenia; BRCA cis rs651907 0.535 rs11919389 chr3:101424458 T/C cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.34 -0.31 4.71e-16 Colorectal cancer; BRCA trans rs11165623 0.792 rs6701031 chr1:96975515 C/T cg10631902 chr5:14652156 NA -0.5 -15.4 -0.52 9.79e-46 Hip circumference;Waist circumference; BRCA trans rs1005277 0.579 rs2472183 chr10:38392495 T/G cg17830980 chr10:43048298 ZNF37B -0.57 -13.96 -0.48 7.91e-39 Extrinsic epigenetic age acceleration; BRCA cis rs4466137 0.953 rs1585153 chr5:83000385 A/T cg16102102 chr5:83017553 HAPLN1 -0.91 -18.35 -0.59 1.04e-60 Prostate cancer; BRCA cis rs709400 0.567 rs28496120 chr14:103897899 C/T cg12935359 chr14:103987150 CKB -0.6 -14.31 -0.49 1.7e-40 Body mass index; BRCA cis rs4718428 0.672 rs36038499 chr7:66289615 A/G cg12165864 chr7:66369176 NA -0.44 -9.87 -0.36 1.69e-21 Corneal structure; BRCA cis rs17376456 1.000 rs9968691 chr5:93509756 C/G cg21475434 chr5:93447410 FAM172A 0.69 8.96 0.33 3.44e-18 Diabetic retinopathy; BRCA cis rs7811142 0.830 rs73401443 chr7:99977582 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.44 0.68 3.67e-88 Platelet count; BRCA cis rs56399783 0.901 rs56356906 chr7:2774383 G/A cg19731401 chr7:2775893 GNA12 0.52 8.28 0.31 7.04e-16 Childhood ear infection; BRCA cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg04553112 chr3:125709451 NA -0.56 -8.41 -0.32 2.61e-16 Blood pressure (smoking interaction); BRCA cis rs12760731 0.720 rs12022731 chr1:178416358 A/G cg00404053 chr1:178313656 RASAL2 0.6 7.85 0.3 1.75e-14 Obesity-related traits; BRCA cis rs117623576 0.618 rs211416 chr10:32397591 T/A cg03047570 chr10:32398778 NA 0.56 8.83 0.33 1.04e-17 Anti-saccade response; BRCA cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.59e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9467773 0.873 rs9295698 chr6:26566099 T/A cg09904177 chr6:26538194 HMGN4 0.55 17.71 0.57 2.06e-57 Intelligence (multi-trait analysis); BRCA cis rs9649465 0.934 rs7799354 chr7:123269819 A/G cg03229431 chr7:123269106 ASB15 -0.36 -8.39 -0.31 3.2e-16 Migraine; BRCA cis rs17666538 0.585 rs1669733 chr8:606696 C/T cg07234876 chr8:600039 NA -0.78 -8.73 -0.33 2.14e-17 IgG glycosylation; BRCA cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg14196790 chr5:131705035 SLC22A5 0.42 10.81 0.39 3.84e-25 Blood metabolite levels; BRCA cis rs4853036 0.904 rs62152020 chr2:70147664 C/T cg02498382 chr2:70120550 SNRNP27 -0.54 -9.61 -0.36 1.58e-20 Colorectal or endometrial cancer; BRCA cis rs6430585 0.527 rs76380759 chr2:136438517 G/A cg07169764 chr2:136633963 MCM6 0.99 19.16 0.6 5.54e-65 Corneal structure; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12575642 0.660 rs58632573 chr11:63896299 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.44 0.32 2.19e-16 Attention deficit hyperactivity disorder; BRCA cis rs7666738 0.830 rs17027058 chr4:98864671 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.89 0.51 2.75e-43 Colonoscopy-negative controls vs population controls; BRCA trans rs637571 0.546 rs11227309 chr11:65584512 A/C cg17712092 chr4:129076599 LARP1B -0.53 -12.2 -0.43 6.61e-31 Eosinophil percentage of white cells; BRCA trans rs561341 1.000 rs555629 chr17:30294136 T/C cg20587970 chr11:113659929 NA -1.2 -22.13 -0.66 5.45e-81 Hip circumference adjusted for BMI; BRCA cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg16414030 chr3:133502952 NA -0.48 -11.27 -0.41 5.25e-27 Iron status biomarkers; BRCA cis rs9487051 0.738 rs449850 chr6:109525045 A/G cg01475377 chr6:109611718 NA -0.44 -11.11 -0.4 2.51e-26 Reticulocyte fraction of red cells; BRCA cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg21475434 chr5:93447410 FAM172A 0.71 8.9 0.33 5.68e-18 Diabetic retinopathy; BRCA cis rs801193 0.839 rs12534943 chr7:66070520 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -9.0 -0.34 2.61e-18 Aortic root size; BRCA cis rs7666738 0.753 rs17027308 chr4:99091088 T/A cg05340658 chr4:99064831 C4orf37 0.6 13.55 0.47 5.68e-37 Colonoscopy-negative controls vs population controls; BRCA cis rs7819412 0.505 rs17726209 chr8:11022185 C/T cg21775007 chr8:11205619 TDH 0.53 10.51 0.38 6e-24 Triglycerides; BRCA cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg20887711 chr4:1340912 KIAA1530 -0.73 -15.95 -0.53 1.92e-48 Longevity; BRCA cis rs6582630 0.555 rs35284307 chr12:38509999 T/G cg26384229 chr12:38710491 ALG10B 0.74 17.66 0.57 3.84e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs9914988 0.943 rs7215310 chr17:27088626 G/T cg20469991 chr17:27169893 C17orf63 -0.44 -8.64 -0.32 4.39e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs7200543 1.000 rs6498540 chr16:15130594 A/G cg24683922 chr1:11983373 KIAA2013 -0.39 -8.86 -0.33 8.19e-18 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs1109501 1.000 rs11932207 chr4:71330534 G/A cg22786090 chr4:71381880 NA 0.37 7.85 0.3 1.77e-14 Alcoholism (heaviness of drinking); BRCA cis rs13082711 0.911 rs17682751 chr3:27497027 C/T cg02860705 chr3:27208620 NA -0.59 -11.01 -0.4 6.21e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs13095912 1.000 rs2034343 chr3:185337854 A/T cg11274856 chr3:185301563 NA 0.34 8.39 0.31 3.22e-16 Systolic blood pressure; BRCA cis rs8062405 1.000 rs7205323 chr16:28865892 C/T cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs17685 0.535 rs41296542 chr7:75600008 A/G cg19862616 chr7:65841803 NCRNA00174 0.36 8.65 0.32 4.1e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.86 -0.33 8.18e-18 Total body bone mineral density; BRCA cis rs9487051 0.768 rs386696 chr6:109520166 G/A cg01475377 chr6:109611718 NA -0.44 -11.28 -0.41 4.89e-27 Reticulocyte fraction of red cells; BRCA cis rs7772486 0.875 rs9322045 chr6:146384950 C/G cg05347473 chr6:146136440 FBXO30 0.39 7.88 0.3 1.45e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.38 -9.15 -0.34 7.42e-19 Tonsillectomy; BRCA cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg08917208 chr2:24149416 ATAD2B -0.5 -8.33 -0.31 5.01e-16 Asthma; BRCA cis rs9372253 1.000 rs9372253 chr6:110716136 C/T cg01119278 chr6:110721349 DDO -0.43 -10.54 -0.38 4.87e-24 Platelet distribution width; BRCA cis rs6723226 0.765 rs12612824 chr2:32579759 C/T cg02381751 chr2:32503542 YIPF4 -0.67 -14.44 -0.5 3.96e-41 Intelligence (multi-trait analysis); BRCA cis rs1475911 0.708 rs66994219 chr21:43521647 G/A cg19766460 chr21:43528205 UMODL1;C21orf128 0.92 19.19 0.6 3.64e-65 IgG glycosylation; BRCA cis rs7772486 0.875 rs9373483 chr6:146364194 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.56 -0.32 8.47e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg23708337 chr7:1209742 NA 0.38 7.94 0.3 9.24e-15 Longevity;Endometriosis; BRCA cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg25204440 chr1:209979598 IRF6 0.43 8.58 0.32 7.08e-17 Cleft lip with or without cleft palate; BRCA cis rs4819052 0.851 rs28442024 chr21:46674475 C/A cg11663144 chr21:46675770 NA -0.6 -14.13 -0.49 1.24e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs698833 0.757 rs9309116 chr2:44557919 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.5 0.38 6.56e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs6088580 0.634 rs2225837 chr20:33005634 C/T cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs36051895 0.664 rs62543877 chr9:5093465 C/A cg02405213 chr9:5042618 JAK2 -0.51 -9.08 -0.34 1.35e-18 Pediatric autoimmune diseases; BRCA cis rs9814567 1.000 rs7630874 chr3:134293291 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.78 0.62 2.8e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1801251 1.000 rs13008942 chr2:233594875 G/A cg08000102 chr2:233561755 GIGYF2 0.63 13.88 0.48 1.8e-38 Coronary artery disease; BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07256732 chr16:621771 PIGQ -0.34 -8.87 -0.33 7.31e-18 Height; BRCA cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs1801251 0.964 rs7589201 chr2:233724536 A/G cg08000102 chr2:233561755 GIGYF2 -0.62 -13.63 -0.47 2.44e-37 Coronary artery disease; BRCA cis rs9790314 0.715 rs9290065 chr3:160776964 A/G cg03342759 chr3:160939853 NMD3 0.51 9.77 0.36 4.2e-21 Morning vs. evening chronotype; BRCA cis rs9649465 0.902 rs10253850 chr7:123273095 T/C cg03229431 chr7:123269106 ASB15 -0.37 -8.4 -0.32 2.82e-16 Migraine; BRCA trans rs3960554 0.733 rs59170362 chr7:75629267 G/C cg19862616 chr7:65841803 NCRNA00174 0.55 11.58 0.42 2.72e-28 Eotaxin levels; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg04025307 chr7:1156635 C7orf50 0.52 10.12 0.37 1.92e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs9291683 0.679 rs3756225 chr4:10094133 G/C cg26043149 chr18:55253948 FECH -0.41 -9.12 -0.34 9.72e-19 Bone mineral density; BRCA cis rs17095355 1.000 rs734163 chr10:111698192 A/G cg00817464 chr10:111662876 XPNPEP1 -0.34 -8.84 -0.33 9.04e-18 Biliary atresia; BRCA cis rs7481584 0.624 rs440130 chr11:3051476 A/G cg08508325 chr11:3079039 CARS 0.27 8.32 0.31 5.53e-16 Calcium levels; BRCA cis rs9427116 0.502 rs9426830 chr1:154594690 A/G cg17218026 chr1:154582156 ADAR 0.28 8.53 0.32 1.09e-16 Blood protein levels; BRCA cis rs524281 0.861 rs10896077 chr11:65851733 C/G cg16950941 chr11:66035639 RAB1B -0.38 -7.97 -0.3 7.32e-15 Electroencephalogram traits; BRCA cis rs2061333 1.000 rs2061333 chr19:44614208 A/G cg23489630 chr19:44645078 ZNF234 0.42 8.28 0.31 7.35e-16 Alzheimer's disease; BRCA cis rs870825 0.616 rs7667449 chr4:185641711 T/C cg04058563 chr4:185651563 MLF1IP 0.76 16.76 0.55 1.57e-52 Blood protein levels; BRCA cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs597539 0.652 rs10792001 chr11:68637737 G/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 16.51 0.55 2.77e-51 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs2153535 0.580 rs5001322 chr6:8451608 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg04013093 chr6:42928303 GNMT 0.3 9.2 0.34 5.03e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10242455 0.557 rs73403272 chr7:99134208 T/G cg18809830 chr7:99032528 PTCD1 -0.58 -8.51 -0.32 1.22e-16 Blood metabolite levels; BRCA cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg21770322 chr7:97807741 LMTK2 0.44 11.56 0.42 3.32e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs61931739 0.500 rs11513287 chr12:34584351 G/A cg06521331 chr12:34319734 NA -0.55 -9.87 -0.36 1.82e-21 Morning vs. evening chronotype; BRCA cis rs4742903 0.904 rs10114234 chr9:107003646 C/T cg21169611 chr9:106856078 SMC2 -0.32 -8.29 -0.31 6.62e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg14019146 chr3:50243930 SLC38A3 0.41 10.03 0.37 4.27e-22 Body mass index; BRCA cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg04267008 chr7:1944627 MAD1L1 -0.53 -12.05 -0.43 2.87e-30 Bipolar disorder and schizophrenia; BRCA trans rs2204008 0.658 rs11181310 chr12:38315963 C/A cg06521331 chr12:34319734 NA -0.48 -8.75 -0.33 1.9e-17 Bladder cancer; BRCA cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.5 0.57 2.65e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs9467773 1.000 rs1535277 chr6:26567802 G/T cg09904177 chr6:26538194 HMGN4 0.55 17.65 0.57 4.4e-57 Intelligence (multi-trait analysis); BRCA cis rs7824557 0.767 rs7003241 chr8:11169075 A/G cg21775007 chr8:11205619 TDH 0.61 11.76 0.42 4.84e-29 Retinal vascular caliber; BRCA trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg20587970 chr11:113659929 NA -1.21 -21.69 -0.65 1.43e-78 Hip circumference adjusted for BMI; BRCA cis rs4595586 0.545 rs11615638 chr12:39364766 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.39e-19 Morning vs. evening chronotype; BRCA cis rs6831352 0.879 rs36034266 chr4:100061388 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.71 -0.36 7.24e-21 Alcohol dependence; BRCA cis rs4588572 0.606 rs2362828 chr5:77718835 C/T cg11547950 chr5:77652471 NA -0.43 -8.28 -0.31 7.41e-16 Triglycerides; BRCA cis rs4363385 0.818 rs546666 chr1:153015385 A/G cg24667326 chr1:152973720 SPRR3 -0.32 -8.83 -0.33 1.04e-17 Inflammatory skin disease; BRCA cis rs400736 0.671 rs863171 chr1:7992615 A/G cg25007680 chr1:8021821 PARK7 0.41 10.27 0.38 5.44e-23 Response to antidepressants and depression; BRCA cis rs17270561 0.636 rs11794 chr6:25701718 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 8.92 0.33 4.72e-18 Iron status biomarkers; BRCA cis rs6815814 0.950 rs56357984 chr4:38806462 G/A cg02016764 chr4:38805732 TLR1 -0.57 -8.7 -0.33 2.83e-17 Breast cancer; BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg13880726 chr7:1868755 MAD1L1 0.53 9.99 0.37 6.19e-22 Bipolar disorder and schizophrenia; BRCA cis rs1865760 0.865 rs10946800 chr6:25957773 C/T cg16482183 chr6:26056742 HIST1H1C 0.51 10.58 0.39 3.17e-24 Height; BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg00080972 chr5:178986291 RUFY1 0.39 10.24 0.38 6.58e-23 Lung cancer; BRCA cis rs2251381 0.808 rs7364112 chr21:30548968 C/A cg24692254 chr21:30365293 RNF160 0.62 13.96 0.48 7.52e-39 Selective IgA deficiency; BRCA cis rs1448094 0.512 rs7953318 chr12:86245929 G/A cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.83e-19 Major depressive disorder; BRCA cis rs7246657 0.722 rs968073 chr19:38192021 G/A cg18154014 chr19:37997991 ZNF793 -0.51 -9.58 -0.35 2.03e-20 Coronary artery calcification; BRCA cis rs35849525 1.000 rs35849525 chr3:50067350 T/C cg14019146 chr3:50243930 SLC38A3 -0.59 -12.07 -0.43 2.37e-30 Intelligence (multi-trait analysis); BRCA cis rs7659604 0.539 rs3217771 chr4:122739483 G/A cg19748678 chr4:122722346 EXOSC9 0.74 16.02 0.54 8.68e-49 Type 2 diabetes; BRCA trans rs11098499 0.863 rs1552092 chr4:120488496 C/T cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs853679 0.517 rs9348794 chr6:28117757 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Depression; BRCA cis rs9287719 0.967 rs7566875 chr2:10754792 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs701145 0.938 rs701138 chr3:154063609 T/C cg17054900 chr3:154042577 DHX36 0.66 11.41 0.41 1.46e-27 Coronary artery disease; BRCA cis rs6815814 0.898 rs73236616 chr4:38789675 G/A cg02016764 chr4:38805732 TLR1 -0.63 -9.72 -0.36 6.24e-21 Breast cancer; BRCA cis rs1941023 0.503 rs10750936 chr11:60144180 G/A cg08716584 chr11:60157161 MS4A7 -0.44 -10.53 -0.38 5.33e-24 Congenital heart disease (maternal effect); BRCA cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg06115741 chr20:33292138 TP53INP2 0.41 9.02 0.34 2.11e-18 Coronary artery disease; BRCA cis rs2276314 1.000 rs9304154 chr18:33562227 C/T cg19628046 chr18:33552617 C18orf21 0.56 10.98 0.4 8.53e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1707322 0.827 rs6694302 chr1:46245645 A/T cg03146154 chr1:46216737 IPP 0.53 11.81 0.42 2.91e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs698833 0.548 rs1067350 chr2:44669946 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.15 0.34 7.79e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs208520 0.690 rs1885100 chr6:66871047 C/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.99 -20.44 -0.63 7.57e-72 Exhaled nitric oxide output; BRCA cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg26818010 chr10:134567672 INPP5A -0.66 -14.34 -0.49 1.19e-40 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg18132916 chr6:79620363 NA -0.46 -10.47 -0.38 8.71e-24 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.605 rs4235354 chr4:10122942 C/A cg26043149 chr18:55253948 FECH -0.38 -7.92 -0.3 1.09e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7474896 0.526 rs1208633 chr10:38156873 A/C cg25427524 chr10:38739819 LOC399744 0.59 11.08 0.4 3.27e-26 Obesity (extreme); BRCA cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg25801113 chr15:45476975 SHF -0.33 -8.05 -0.3 4.19e-15 Uric acid levels; BRCA cis rs7809950 1.000 rs67982599 chr7:107100104 T/G cg23024343 chr7:107201750 COG5 -0.4 -9.3 -0.35 2.24e-19 Coronary artery disease; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg08888203 chr3:10149979 C3orf24 0.68 14.46 0.5 3.41e-41 Alzheimer's disease; BRCA cis rs754466 0.580 rs11002294 chr10:79540588 T/C cg17075019 chr10:79541650 NA -0.83 -20.46 -0.63 5.94e-72 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2806561 0.704 rs667330 chr1:23515257 A/G cg12483005 chr1:23474871 LUZP1 0.44 9.81 0.36 2.84e-21 Height; BRCA cis rs507080 0.845 rs510408 chr11:118558901 G/C cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.89 0.33 5.97e-18 Tonsillectomy; BRCA cis rs6952808 0.595 rs3778982 chr7:2166233 T/C cg05863683 chr7:1912471 MAD1L1 0.4 8.38 0.31 3.27e-16 Bipolar disorder and schizophrenia; BRCA cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.1 0.62 5.33e-70 Smoking behavior; BRCA trans rs61931739 0.513 rs1463634 chr12:33899621 A/G cg26384229 chr12:38710491 ALG10B 0.48 11.07 0.4 3.59e-26 Morning vs. evening chronotype; BRCA cis rs2425143 0.730 rs6058354 chr20:34491110 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.15 -0.31 1.89e-15 Blood protein levels; BRCA cis rs9381040 0.674 rs3747742 chr6:41162518 C/T cg04346459 chr6:41068666 NFYA;LOC221442 0.4 7.97 0.3 7.06e-15 Alzheimer's disease (late onset); BRCA cis rs1215050 0.791 rs260893 chr4:98744785 A/C cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2243480 0.908 rs1532573 chr7:65798802 A/G cg18252515 chr7:66147081 NA 1.06 15.88 0.53 3.95e-48 Diabetic kidney disease; BRCA cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg06808227 chr14:105710500 BRF1 -0.79 -16.1 -0.54 3.13e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs1555322 0.530 rs6060341 chr20:33863633 C/T cg07134254 chr20:33865797 NA -0.43 -8.26 -0.31 8.72e-16 Attention deficit hyperactivity disorder; BRCA cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg24562669 chr7:97807699 LMTK2 0.43 11.48 0.41 7.55e-28 Prostate cancer (SNP x SNP interaction); BRCA trans rs1005277 0.579 rs2472182 chr10:38388865 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs35306767 0.855 rs11253468 chr10:903261 G/A cg26597838 chr10:835615 NA 0.98 17.29 0.56 3.09e-55 Eosinophil percentage of granulocytes; BRCA cis rs9462027 0.628 rs6905393 chr6:34776626 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.84 -0.3 1.96e-14 Systemic lupus erythematosus; BRCA cis rs9815354 0.857 rs73830583 chr3:41996948 C/T cg03022575 chr3:42003672 ULK4 0.73 10.08 0.37 2.94e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs2153535 0.580 rs969421 chr6:8451949 A/C cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs1348850 0.526 rs59972556 chr2:178399561 A/G cg27490568 chr2:178487706 NA 0.49 8.43 0.32 2.29e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs3806843 0.733 rs801181 chr5:140092814 C/T cg26395211 chr5:140044315 WDR55 0.37 8.32 0.31 5.16e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs3008870 1.000 rs2985795 chr1:67426223 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.44 0.66 1.14e-82 Lymphocyte percentage of white cells; BRCA cis rs672059 0.966 rs492228 chr1:183156476 T/C ch.1.3577855R chr1:183094577 LAMC1 0.37 8.64 0.32 4.48e-17 Hypertriglyceridemia; BRCA cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg01448562 chr3:133502909 NA -0.64 -15.19 -0.52 1.02e-44 Iron status biomarkers; BRCA cis rs877282 0.945 rs71489301 chr10:770191 A/G cg17470449 chr10:769945 NA 0.48 8.9 0.33 5.94e-18 Uric acid levels; BRCA cis rs210143 1 rs210143 chr6:33546930 T/C cg07679836 chr6:33548423 BAK1 0.65 13.86 0.48 2.11e-38 Neutrophil percentage of granulocytes;B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy);Chronic lymphocytic leukemia; BRCA cis rs7255436 0.830 rs4350678 chr19:8447366 A/G cg10174797 chr19:8464628 RAB11B 0.35 8.91 0.33 5.26e-18 HDL cholesterol; BRCA cis rs7412746 0.658 rs72704685 chr1:150897687 C/G cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.26e-14 Melanoma; BRCA trans rs61931739 0.929 rs2389274 chr12:34075149 T/C cg26384229 chr12:38710491 ALG10B -0.43 -10.3 -0.38 3.91e-23 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs1317817 chr6:25765377 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 9.68 0.36 9.18e-21 Iron status biomarkers; BRCA cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg19678392 chr7:94953810 PON1 -0.43 -8.98 -0.33 3e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs3849570 1.000 rs9817181 chr3:81827765 A/C cg07356753 chr3:81810745 GBE1 -0.47 -11.29 -0.41 4.46e-27 Waist circumference;Body mass index; BRCA cis rs10493773 1.000 rs3767163 chr1:86121895 T/G cg17807903 chr1:86174739 ZNHIT6 -0.44 -9.12 -0.34 9.8e-19 Urate levels in overweight individuals; BRCA cis rs12618769 0.597 rs2278213 chr2:99136059 A/G cg10123293 chr2:99228465 UNC50 0.41 7.93 0.3 9.97e-15 Bipolar disorder; BRCA cis rs61931739 0.500 rs11053223 chr12:34481947 T/A cg06521331 chr12:34319734 NA -0.56 -10.19 -0.37 1.09e-22 Morning vs. evening chronotype; BRCA cis rs651907 0.557 rs34376498 chr3:101480156 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.61 14.8 0.51 7.61e-43 Colorectal cancer; BRCA cis rs2066819 1.000 rs2306694 chr12:56680636 C/T cg26714650 chr12:56694279 CS 1.18 15.85 0.53 5.52e-48 Psoriasis vulgaris; BRCA cis rs6088580 0.634 rs6088475 chr20:32964987 T/C cg24642439 chr20:33292090 TP53INP2 -0.52 -11.5 -0.41 6.15e-28 Glomerular filtration rate (creatinine); BRCA cis rs7772486 0.719 rs7753770 chr6:146066161 G/A cg05347473 chr6:146136440 FBXO30 -0.44 -8.81 -0.33 1.17e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs300703 0.719 rs385272 chr2:206704 A/G cg21211680 chr2:198530 NA -0.46 -10.03 -0.37 4.5e-22 Blood protein levels; BRCA cis rs2075671 0.903 rs4727459 chr7:100276821 T/C cg16850897 chr7:100343110 ZAN -0.58 -12.37 -0.44 1.16e-31 Other erythrocyte phenotypes; BRCA cis rs4642101 0.561 rs9831765 chr3:12805934 A/T cg24848339 chr3:12840334 CAND2 0.38 9.24 0.34 3.72e-19 QRS complex (12-leadsum); BRCA cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg11752832 chr7:134001865 SLC35B4 0.53 13.81 0.48 3.83e-38 Mean platelet volume; BRCA cis rs9467773 1.000 rs11756120 chr6:26529808 G/C cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs9834755 chr3:134206845 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.87 -0.33 7.06e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2204008 0.805 rs4589389 chr12:37946120 C/A cg26384229 chr12:38710491 ALG10B -0.57 -13.29 -0.47 9.4e-36 Bladder cancer; BRCA cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg03517284 chr6:25882590 NA -0.73 -17.68 -0.57 2.92e-57 Uric acid levels; BRCA cis rs7092929 0.941 rs661019 chr10:3586581 C/T cg14308648 chr10:3568949 NA 0.45 8.1 0.31 2.73e-15 Coronary artery calcification; BRCA trans rs11088226 0.681 rs2833926 chr21:33975279 A/G cg09050820 chr6:167586206 TCP10L2 0.82 14.06 0.49 2.7e-39 Gastritis; BRCA cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg14993813 chr1:46806288 NSUN4 -0.47 -9.05 -0.34 1.75e-18 Menopause (age at onset); BRCA cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg09469691 chr10:81107165 PPIF 0.49 10.29 0.38 4.57e-23 Height; BRCA cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg13877915 chr19:58951672 ZNF132 -0.45 -10.81 -0.39 3.99e-25 Uric acid clearance; BRCA cis rs6570726 0.791 rs398408 chr6:145801020 G/A cg23711669 chr6:146136114 FBXO30 0.74 17.1 0.56 2.91e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs5167 0.504 rs3760627 chr19:45457180 T/C cg10169327 chr19:45448959 APOC2 0.31 7.84 0.3 1.94e-14 Blood protein levels; BRCA cis rs5758659 0.652 rs133305 chr22:42395960 C/T cg05082376 chr22:42548792 NA -0.31 -7.86 -0.3 1.67e-14 Cognitive function; BRCA cis rs9399135 0.967 rs9389256 chr6:135331254 A/C cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.66e-31 Red blood cell count; BRCA cis rs950169 0.519 rs7237 chr15:85186577 C/T cg17173187 chr15:85201210 NMB 0.42 8.71 0.33 2.55e-17 Schizophrenia; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg04025307 chr7:1156635 C7orf50 0.55 13.31 0.47 7.19e-36 Longevity;Endometriosis; BRCA cis rs1506636 1.000 rs2402669 chr7:123297460 C/G cg03229431 chr7:123269106 ASB15 -0.64 -14.3 -0.49 1.95e-40 Plateletcrit;Platelet count; BRCA cis rs7772486 0.790 rs9376970 chr6:146241472 A/C cg13319975 chr6:146136371 FBXO30 0.42 9.54 0.35 2.88e-20 Lobe attachment (rater-scored or self-reported); BRCA trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.89 -0.56 3.51e-53 Intelligence (multi-trait analysis); BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.35 0.35 1.49e-19 Tonsillectomy; BRCA cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.57 0.35 2.25e-20 Lung cancer in ever smokers; BRCA cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg23711669 chr6:146136114 FBXO30 -0.7 -16.77 -0.55 1.33e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089829 1.000 rs62207535 chr20:61669187 A/G cg02544614 chr20:61657117 NA 0.3 8.22 0.31 1.15e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg24642439 chr20:33292090 TP53INP2 0.52 11.43 0.41 1.2e-27 Glomerular filtration rate (creatinine); BRCA cis rs3925075 0.966 rs11645917 chr16:31359826 C/T cg02846316 chr16:31340340 ITGAM 0.53 12.86 0.45 8.02e-34 IgA nephropathy; BRCA cis rs35306767 0.807 rs11253513 chr10:968450 C/T cg26597838 chr10:835615 NA 0.83 15.2 0.52 9.58e-45 Eosinophil percentage of granulocytes; BRCA cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg25382214 chr1:3105252 PRDM16 -0.34 -7.93 -0.3 1.01e-14 Migraine; BRCA cis rs7683537 0.887 rs4540092 chr4:185633546 A/G cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Systemic lupus erythematosus; BRCA cis rs17270561 0.609 rs4132072 chr6:25717843 C/T cg16482183 chr6:26056742 HIST1H1C 0.43 8.39 0.32 3.1e-16 Iron status biomarkers; BRCA trans rs877282 0.853 rs11595507 chr10:756703 C/T cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs9790314 0.747 rs1610158 chr3:160815050 A/G cg04691961 chr3:161091175 C3orf57 0.38 8.37 0.31 3.61e-16 Morning vs. evening chronotype; BRCA cis rs1163251 0.902 rs487081 chr1:120217389 G/A cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs250677 0.687 rs168750 chr5:148446756 A/G cg23229984 chr5:148520753 ABLIM3 0.36 8.74 0.33 2.06e-17 Breast cancer; BRCA cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg23788917 chr6:8435910 SLC35B3 0.47 10.2 0.37 9.77e-23 Motion sickness; BRCA cis rs9868809 0.505 rs13063223 chr3:48750340 G/A cg07636037 chr3:49044803 WDR6 -0.58 -7.94 -0.3 8.9e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs10206020 0.885 rs11887527 chr2:1578080 A/G cg01028140 chr2:1542097 TPO -0.57 -11.59 -0.42 2.6e-28 IgG glycosylation; BRCA cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg24642439 chr20:33292090 TP53INP2 0.72 16.28 0.54 4.17e-50 Coronary artery disease; BRCA cis rs1018836 0.923 rs4735260 chr8:91617157 C/G cg16814680 chr8:91681699 NA 0.59 12.64 0.45 7.6e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.53 8.52 0.32 1.12e-16 Renal function-related traits (BUN); BRCA cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg19077165 chr18:44547161 KATNAL2 -0.61 -13.89 -0.48 1.57e-38 Personality dimensions; BRCA cis rs2625529 0.617 rs2128112 chr15:72186286 A/T cg16672083 chr15:72433130 SENP8 0.67 16.17 0.54 1.53e-49 Red blood cell count; BRCA cis rs933688 1.000 rs1035476 chr5:90745976 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 20.08 0.62 7.08e-70 Smoking behavior; BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.61 -11.79 -0.42 3.53e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11722228 0.549 rs73212830 chr4:10078759 A/T cg26043149 chr18:55253948 FECH 1.09 23.1 0.67 2.65e-86 Gout;Urate levels;Serum uric acid levels; BRCA cis rs8016982 0.698 rs8021385 chr14:81704682 G/A cg01989461 chr14:81687754 GTF2A1 0.6 14.22 0.49 4.63e-40 Schizophrenia; BRCA cis rs11792861 0.781 rs838835 chr9:111758590 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 -0.52 -10.5 -0.38 6.98e-24 Menarche (age at onset); BRCA cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg06784218 chr1:46089804 CCDC17 -0.45 -10.87 -0.4 2.17e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10501293 0.956 rs10837999 chr11:43068860 T/G cg03447554 chr11:43094025 NA 0.5 9.09 0.34 1.27e-18 Cognitive performance; BRCA cis rs523522 0.962 rs3893104 chr12:120903936 G/A cg12219531 chr12:120966889 COQ5 0.56 11.52 0.41 5.18e-28 High light scatter reticulocyte count; BRCA cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg02951883 chr7:2050386 MAD1L1 -0.53 -11.39 -0.41 1.75e-27 Bipolar disorder and schizophrenia; BRCA cis rs72781680 0.851 rs72796397 chr2:24178211 T/A cg20701182 chr2:24300061 SF3B14 0.59 9.31 0.35 2.03e-19 Lymphocyte counts; BRCA cis rs6089584 0.927 rs6089593 chr20:60572312 G/A cg06108461 chr20:60628389 TAF4 -0.79 -16.9 -0.56 3.02e-53 Body mass index; BRCA cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg13660082 chr14:53194042 PSMC6 -0.56 -8.19 -0.31 1.39e-15 Alzheimer's disease (late onset); BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -11.37 -0.41 2.11e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg09436375 chr6:42928200 GNMT -0.29 -10.89 -0.4 1.87e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.619 rs2302918 chr7:66000932 A/G cg18876405 chr7:65276391 NA 0.62 15.22 0.52 7.6e-45 Aortic root size; BRCA cis rs4665809 1.000 rs1550382 chr2:26266877 T/G cg22920501 chr2:26401640 FAM59B -0.66 -11.52 -0.41 5e-28 Gut microbiome composition (summer); BRCA cis rs12579753 0.871 rs10862364 chr12:82201280 C/T cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs7707921 0.522 rs4703537 chr5:81480371 C/T cg15871215 chr5:81402204 ATG10 0.35 8.86 0.33 7.62e-18 Breast cancer; BRCA trans rs4332037 0.539 rs4719416 chr7:2106608 G/A cg11693508 chr17:37793320 STARD3 0.39 8.06 0.3 3.8e-15 Bipolar disorder; BRCA cis rs6942756 1.000 rs2718084 chr7:128897342 T/C cg02491457 chr7:128862824 NA 0.64 13.01 0.46 1.69e-34 White matter hyperintensity burden; BRCA cis rs2243480 1.000 rs316321 chr7:65611613 G/A cg18252515 chr7:66147081 NA -1.04 -15.49 -0.52 3.67e-46 Diabetic kidney disease; BRCA cis rs1949733 1.000 rs1916326 chr4:8500023 G/A cg11789530 chr4:8429930 ACOX3 -0.68 -17.92 -0.58 1.65e-58 Response to antineoplastic agents; BRCA cis rs2235642 1.000 rs2235642 chr16:1584866 T/C cg26528668 chr16:1614120 IFT140 0.37 8.37 0.31 3.61e-16 Coronary artery disease; BRCA cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg22535103 chr8:58192502 C8orf71 -0.61 -13.25 -0.46 1.34e-35 Developmental language disorder (linguistic errors); BRCA cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg18904891 chr8:8559673 CLDN23 0.64 12.61 0.45 1.06e-32 Obesity-related traits; BRCA cis rs12477438 0.798 rs972768 chr2:99682397 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs877529 0.967 rs139405 chr22:39549526 C/A cg18708252 chr22:39545030 CBX7 -0.32 -8.24 -0.31 9.86e-16 Multiple myeloma; BRCA cis rs1865760 0.827 rs9295681 chr6:25944117 T/G cg17691542 chr6:26056736 HIST1H1C 0.48 9.72 0.36 6.51e-21 Height; BRCA cis rs6964587 1.000 rs6960867 chr7:91712698 A/G cg17063962 chr7:91808500 NA 0.53 11.81 0.42 3.01e-29 Breast cancer; BRCA cis rs1059312 0.522 rs3825181 chr12:129279264 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 0.48 9.85 0.36 2.07e-21 Systemic lupus erythematosus; BRCA trans rs7980799 0.905 rs4244865 chr12:33511917 C/T cg26384229 chr12:38710491 ALG10B -0.4 -8.39 -0.32 3.09e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA trans rs853679 0.607 rs34691223 chr6:28258208 C/A cg01620082 chr3:125678407 NA -0.83 -9.94 -0.37 9.21e-22 Depression; BRCA cis rs703842 1.000 rs3825079 chr12:58203354 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.61 12.06 0.43 2.63e-30 Multiple sclerosis; BRCA cis rs9296092 0.517 rs11751684 chr6:33528739 G/T cg13560919 chr6:33536144 NA -0.91 -19.42 -0.61 2.12e-66 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs870825 0.581 rs7675106 chr4:185652388 C/G cg04058563 chr4:185651563 MLF1IP -0.73 -15.84 -0.53 6.2e-48 Blood protein levels; BRCA trans rs877282 1.000 rs71494928 chr10:769134 A/G cg22713356 chr15:30763199 NA 1.36 27.16 0.73 1.37e-108 Uric acid levels; BRCA trans rs11098499 0.954 rs11722872 chr4:120233030 G/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.06 0.3 3.83e-15 Corneal astigmatism; BRCA cis rs2663905 0.611 rs2663924 chr15:81392903 T/G cg09888468 chr15:81410853 NA -0.41 -8.77 -0.33 1.63e-17 QT interval (drug interaction); BRCA cis rs1008375 0.966 rs12503540 chr4:17698781 C/G cg04450456 chr4:17643702 FAM184B -0.32 -8.97 -0.33 3.36e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg21573476 chr21:45109991 RRP1B -0.32 -8.33 -0.31 4.9e-16 Mean corpuscular volume; BRCA cis rs2075371 0.829 rs35897242 chr7:134004041 G/A cg11752832 chr7:134001865 SLC35B4 0.5 11.89 0.43 1.3e-29 Mean platelet volume; BRCA cis rs1552244 1.000 rs7619340 chr3:10108178 C/T cg10729496 chr3:10149963 C3orf24 0.48 8.98 0.33 2.93e-18 Alzheimer's disease; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.6 -12.69 -0.45 4.36e-33 Lymphocyte counts; BRCA cis rs10899021 1.000 rs10899021 chr11:74338054 C/T cg25880958 chr11:74394337 NA 0.48 8.39 0.31 3.22e-16 Response to metformin (IC50); BRCA cis rs6435161 1.000 rs72926986 chr2:203519264 G/T cg18429434 chr2:203499731 FAM117B -0.44 -8.76 -0.33 1.78e-17 Total cholesterol levels; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg09177884 chr7:1199841 ZFAND2A -0.48 -10.4 -0.38 1.72e-23 Longevity;Endometriosis; BRCA cis rs13191362 1.000 rs66789102 chr6:163104432 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.53 8.09 0.3 2.97e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72781680 0.611 rs72781695 chr2:24266744 T/C cg08917208 chr2:24149416 ATAD2B 0.57 9.07 0.34 1.43e-18 Lymphocyte counts; BRCA cis rs739401 0.967 rs451041 chr11:3060725 C/T cg08508325 chr11:3079039 CARS -0.35 -12.55 -0.44 1.88e-32 Longevity; BRCA cis rs2841277 0.770 rs10149193 chr14:105403474 C/T cg19901468 chr14:105411992 AHNAK2 -0.51 -12.45 -0.44 5.25e-32 Rheumatoid arthritis; BRCA cis rs365132 0.875 rs547798 chr5:176326721 C/A cg16309518 chr5:176445507 NA -0.38 -9.33 -0.35 1.74e-19 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs312274 0.551 rs10879397 chr12:41340912 G/A cg17827154 chr12:41323612 CNTN1 -0.36 -7.89 -0.3 1.36e-14 Metabolite levels (X-11787); BRCA cis rs11718455 0.960 rs13083325 chr3:44005333 T/C cg08738300 chr3:44038990 NA 0.45 8.61 0.32 5.58e-17 Coronary artery disease; BRCA cis rs7267979 1.000 rs2257808 chr20:25266450 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.84 0.36 2.26e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg10802521 chr3:52805072 NEK4 -0.34 -9.17 -0.34 6.66e-19 Intelligence (multi-trait analysis); BRCA cis rs30380 1.000 rs246454 chr5:96123264 C/A cg16492584 chr5:96139282 ERAP1 -0.31 -7.96 -0.3 7.6e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.3 0.31 6.09e-16 Breast cancer; BRCA cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg11822812 chr5:140052017 DND1 -0.3 -8.24 -0.31 9.93e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs4363385 0.747 rs946098 chr1:152975038 A/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.24 -0.31 1.01e-15 Inflammatory skin disease; BRCA cis rs2243480 0.901 rs35256305 chr7:65306405 T/C cg18252515 chr7:66147081 NA -0.8 -11.18 -0.4 1.23e-26 Diabetic kidney disease; BRCA cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.43 9.53 0.35 3.16e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11098499 0.644 rs7676296 chr4:120555687 A/G cg09307838 chr4:120376055 NA 0.59 12.34 0.44 1.63e-31 Corneal astigmatism; BRCA cis rs11997175 0.583 rs12680755 chr8:33815282 G/A ch.8.33884649F chr8:33765107 NA 0.37 8.29 0.31 6.68e-16 Body mass index; BRCA trans rs9951602 0.512 rs4798994 chr18:76654327 T/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.3 0.59 1.73e-60 Obesity-related traits; BRCA cis rs2742234 0.868 rs2505512 chr10:43633596 G/A cg02780029 chr10:43622663 RET -0.38 -9.26 -0.34 3.04e-19 Hirschsprung disease; BRCA cis rs73242632 0.867 rs28545156 chr4:57879340 C/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.66 7.81 0.3 2.38e-14 Congenital heart disease (maternal effect); BRCA cis rs6582630 0.502 rs11514371 chr12:38306306 G/C cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs6459788 0.934 rs10237947 chr7:157258109 G/T cg03453431 chr7:157225567 NA 0.4 8.14 0.31 2.01e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs826838 1.000 rs11610522 chr12:38687575 C/T cg26384229 chr12:38710491 ALG10B 0.87 23.71 0.68 1.15e-89 Heart rate; BRCA cis rs9325144 0.554 rs7960616 chr12:39096664 T/A cg26384229 chr12:38710491 ALG10B -0.48 -11.23 -0.41 7.65e-27 Morning vs. evening chronotype; BRCA cis rs7586879 1.000 rs10175064 chr2:25117537 T/C cg01884057 chr2:25150051 NA 0.33 8.27 0.31 7.99e-16 Body mass index; BRCA cis rs2130392 0.886 rs2077205 chr4:185637418 C/T cg04058563 chr4:185651563 MLF1IP 0.34 8.27 0.31 7.53e-16 Kawasaki disease; BRCA cis rs736408 0.608 rs4687657 chr3:52852538 G/T cg11645453 chr3:52864694 ITIH4 0.42 10.23 0.38 7.6e-23 Bipolar disorder; BRCA cis rs3849570 0.961 rs7620240 chr3:81762787 G/T cg07356753 chr3:81810745 GBE1 -0.47 -11.35 -0.41 2.4200000000000002e-27 Waist circumference;Body mass index; BRCA cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg04546413 chr19:29218101 NA 0.66 13.28 0.46 1.08e-35 Methadone dose in opioid dependence; BRCA cis rs2070488 0.965 rs7640050 chr3:38525864 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.11 0.62 4.73e-70 Electrocardiographic conduction measures; BRCA cis rs7618915 1.000 rs7618915 chr3:52279594 G/A cg18404041 chr3:52824283 ITIH1 -0.34 -9.32 -0.35 1.84e-19 Bipolar disorder; BRCA cis rs780096 0.546 rs1260320 chr2:27722416 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 0.32 8.33 0.31 4.77e-16 Total body bone mineral density; BRCA cis rs55882075 0.634 rs12518476 chr5:179110850 A/G cg14593053 chr5:179126677 CANX 0.38 9.54 0.35 3.04e-20 Monocyte percentage of white cells; BRCA cis rs2836974 0.526 rs1888488 chr21:40686521 C/T cg22974920 chr21:40686053 BRWD1 -0.38 -8.26 -0.31 8.44e-16 Cognitive function; BRCA cis rs35306767 0.668 rs72760914 chr10:1070952 A/G cg20503657 chr10:835505 NA 0.67 11.12 0.4 2.26e-26 Eosinophil percentage of granulocytes; BRCA cis rs10504229 0.683 rs949856 chr8:58144496 G/A cg20607798 chr8:58055168 NA 0.47 8.22 0.31 1.13e-15 Developmental language disorder (linguistic errors); BRCA cis rs1874326 0.545 rs4620232 chr7:138110210 A/G cg18008034 chr7:138118925 NA -0.45 -9.25 -0.34 3.29e-19 Quantitative traits; BRCA cis rs68170813 0.523 rs75999022 chr7:107017135 C/T cg02696742 chr7:106810147 HBP1 -0.56 -8.53 -0.32 1.07e-16 Coronary artery disease; BRCA cis rs3784262 0.669 rs4646645 chr15:58245151 A/G cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.99 -0.37 6.19e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9790314 0.638 rs17236746 chr3:160646743 A/G cg03342759 chr3:160939853 NMD3 0.44 8.4 0.32 2.8e-16 Morning vs. evening chronotype; BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg07148914 chr20:33460835 GGT7 0.36 8.0 0.3 5.78e-15 Height; BRCA cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg11644478 chr21:40555479 PSMG1 -0.67 -14.31 -0.49 1.65e-40 Cognitive function; BRCA cis rs12762955 0.507 rs7070724 chr10:1040138 C/T cg20503657 chr10:835505 NA -0.41 -8.01 -0.3 5.47e-15 Response to angiotensin II receptor blocker therapy; BRCA cis rs495337 0.760 rs6067275 chr20:48545873 C/A cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs4808199 0.947 rs751858 chr19:19602821 G/C cg03709012 chr19:19516395 GATAD2A 1.07 21.38 0.65 6.4e-77 Nonalcoholic fatty liver disease; BRCA cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg24692254 chr21:30365293 RNF160 -0.66 -17.95 -0.58 1.28e-58 Dental caries; BRCA cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg26408565 chr15:76604113 ETFA -0.4 -8.82 -0.33 1.11e-17 Blood metabolite levels; BRCA cis rs9811920 0.893 rs9814549 chr3:99892190 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.51 -11.79 -0.42 3.64e-29 Axial length; BRCA cis rs4819052 0.851 rs2838834 chr21:46665208 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.42 0.5 5.42e-41 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1797081 0.561 rs2603795 chr10:16860256 A/G cg23933602 chr10:16859644 RSU1 0.58 12.98 0.46 2.44e-34 Platelet distribution width; BRCA cis rs12477438 0.798 rs1993230 chr2:99686079 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.76 -0.5 1.19e-42 Chronic sinus infection; BRCA cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg17509989 chr5:176798049 RGS14 0.66 13.03 0.46 1.32e-34 Hemoglobin concentration;Hematocrit; BRCA cis rs17376456 0.825 rs10038828 chr5:93124056 C/T cg25358565 chr5:93447407 FAM172A 1.16 18.02 0.58 4.93e-59 Diabetic retinopathy; BRCA cis rs736408 0.608 rs35004449 chr3:52852897 G/T cg11645453 chr3:52864694 ITIH4 0.41 9.94 0.37 9.27e-22 Bipolar disorder; BRCA cis rs6121246 0.738 rs6121242 chr20:30410877 T/C cg21427119 chr20:30132790 HM13 -0.42 -8.91 -0.33 5.48e-18 Mean corpuscular hemoglobin; BRCA cis rs2576037 0.561 rs513775 chr18:44396334 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.73 -0.39 7.95e-25 Personality dimensions; BRCA cis rs72772090 0.539 rs11747179 chr5:96112969 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.18 -0.43 8.07e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8180040 1.000 rs4858888 chr3:47405305 C/T cg16586182 chr3:47516702 SCAP 0.59 13.27 0.46 1.08e-35 Colorectal cancer; BRCA cis rs908922 0.676 rs6587686 chr1:152528948 C/T cg20991723 chr1:152506922 NA 0.37 8.29 0.31 6.78e-16 Hair morphology; BRCA cis rs922182 0.617 rs28621460 chr15:64240232 C/T cg24729988 chr15:64271149 DAPK2 0.49 10.74 0.39 7.31e-25 Blood protein levels; BRCA cis rs36051895 0.659 rs1159782 chr9:5078117 T/C cg02405213 chr9:5042618 JAK2 -0.55 -9.86 -0.36 1.99e-21 Pediatric autoimmune diseases; BRCA cis rs2288073 0.965 rs6545340 chr2:24422269 C/G cg06627628 chr2:24431161 ITSN2 -0.65 -12.48 -0.44 4.03e-32 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs11971779 0.618 rs9640925 chr7:139085288 G/A cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs875971 0.789 rs10260426 chr7:65736042 G/T cg18876405 chr7:65276391 NA -0.51 -11.49 -0.41 6.61e-28 Aortic root size; BRCA cis rs1801251 0.964 rs13007783 chr2:233566679 G/A cg25237894 chr2:233734115 C2orf82 0.38 11.07 0.4 3.67e-26 Coronary artery disease; BRCA cis rs8017423 0.586 rs2896134 chr14:90831293 G/A cg04374321 chr14:90722782 PSMC1 -0.48 -11.61 -0.42 2.06e-28 Mortality in heart failure; BRCA cis rs8114671 0.562 rs1013677 chr20:33468793 C/T cg24642439 chr20:33292090 TP53INP2 0.41 8.89 0.33 6.23e-18 Height; BRCA cis rs35306767 0.903 rs11253493 chr10:936931 T/C cg26597838 chr10:835615 NA 1.02 17.86 0.58 3.47e-58 Eosinophil percentage of granulocytes; BRCA trans rs1005277 0.522 rs289645 chr10:37943642 T/C cg17830980 chr10:43048298 ZNF37B -0.41 -9.38 -0.35 1.13e-19 Extrinsic epigenetic age acceleration; BRCA cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg02891314 chr5:179741120 GFPT2 -0.69 -14.02 -0.49 3.96e-39 Height; BRCA cis rs769267 0.631 rs7252981 chr19:19692579 T/C cg03709012 chr19:19516395 GATAD2A -0.49 -9.55 -0.35 2.68e-20 Tonsillectomy; BRCA cis rs7666738 0.716 rs11721453 chr4:99045485 G/T cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs881375 1.000 rs10760118 chr9:123641616 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.62 0.32 5.45e-17 Rheumatoid arthritis; BRCA cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg14847009 chr1:175162515 KIAA0040 0.28 10.73 0.39 7.97e-25 Alcohol dependence; BRCA cis rs2387326 0.717 rs10829342 chr10:129944493 C/T cg16087940 chr10:129947807 NA -0.45 -8.01 -0.3 5.47e-15 Select biomarker traits; BRCA cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg08999081 chr20:33150536 PIGU 0.46 12.83 0.45 1.11e-33 Glomerular filtration rate (creatinine); BRCA cis rs13046373 0.535 rs9980934 chr21:31982988 C/T cg16431978 chr21:31797932 KRTAP13-3 0.37 9.61 0.36 1.61e-20 HDL cholesterol; BRCA cis rs4363385 0.747 rs1413848 chr1:152970210 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.41 -0.35 9.12e-20 Inflammatory skin disease; BRCA cis rs12530845 0.887 rs61360007 chr7:135316879 G/A cg23117316 chr7:135346802 PL-5283 -0.34 -8.07 -0.3 3.47e-15 Red blood cell traits; BRCA cis rs9527 0.590 rs1046411 chr10:104837816 G/A cg04362960 chr10:104952993 NT5C2 0.42 9.53 0.35 3.34e-20 Arsenic metabolism; BRCA cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg06115741 chr20:33292138 TP53INP2 -0.36 -8.11 -0.31 2.57e-15 Glomerular filtration rate (creatinine); BRCA cis rs9393777 0.513 rs9379907 chr6:26654318 C/T cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.81 -0.3 2.39e-14 Intelligence (multi-trait analysis); BRCA cis rs2016266 0.929 rs1318648 chr12:53670545 C/A cg26875137 chr12:53738046 NA 0.36 9.67 0.36 9.52e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs1018836 0.818 rs715057 chr8:91624340 T/C cg16814680 chr8:91681699 NA -0.61 -13.66 -0.48 1.81e-37 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs10751667 0.666 rs6597960 chr11:977036 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs8103278 1.000 rs8108590 chr19:46301620 A/G cg12641515 chr19:46296257 DMWD -0.55 -12.13 -0.43 1.28e-30 Coronary artery disease; BRCA cis rs7811142 1.000 rs67315960 chr7:100015124 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.32 -0.49 1.48e-40 Platelet count; BRCA cis rs4819052 0.679 rs28623526 chr21:46712324 T/C cg11663144 chr21:46675770 NA -0.48 -11.34 -0.41 2.65e-27 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1008375 1.000 rs10939746 chr4:17684951 A/G cg16339924 chr4:17578868 LAP3 -0.6 -14.83 -0.51 5.83e-43 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35110281 0.563 rs162371 chr21:44931489 G/T cg04455712 chr21:45112962 RRP1B 0.36 9.15 0.34 7.38e-19 Mean corpuscular volume; BRCA cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg08085267 chr17:45401833 C17orf57 0.61 12.51 0.44 2.97e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4478858 0.684 rs10798839 chr1:31731758 C/G cg00250761 chr1:31883323 NA -0.31 -8.08 -0.3 3.2e-15 Alcohol dependence; BRCA cis rs79839061 0.518 rs3755960 chr4:895060 G/T cg07828340 chr4:882639 GAK 1.01 14.1 0.49 1.72e-39 Intelligence (multi-trait analysis); BRCA cis rs7246967 0.673 rs9676498 chr19:22910510 A/G cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.5e-19 Bronchopulmonary dysplasia; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg04013093 chr6:42928303 GNMT -0.27 -8.26 -0.31 8.36e-16 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2777491 0.874 rs28716108 chr15:41655523 G/C cg18705301 chr15:41695430 NDUFAF1 -0.66 -14.97 -0.51 1.15e-43 Ulcerative colitis; BRCA trans rs6582630 0.555 rs11181684 chr12:38388000 T/C cg06521331 chr12:34319734 NA -0.44 -8.34 -0.31 4.57e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs9487051 0.597 rs12664455 chr6:109590739 C/T cg01475377 chr6:109611718 NA -0.41 -7.84 -0.3 1.91e-14 Reticulocyte fraction of red cells; BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg25036284 chr2:26402008 FAM59B -0.64 -10.67 -0.39 1.39e-24 Gut microbiome composition (summer); BRCA trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21659725 chr3:3221576 CRBN 0.51 12.09 0.43 1.98e-30 Resting heart rate; BRCA cis rs3770081 1.000 rs12617717 chr2:86342303 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -0.66 -8.76 -0.33 1.79e-17 Facial emotion recognition (sad faces); BRCA cis rs7582180 0.739 rs4851292 chr2:100924761 A/G cg14675211 chr2:100938903 LONRF2 0.49 11.18 0.4 1.22e-26 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.694 rs10880262 chr12:38328696 C/T cg26384229 chr12:38710491 ALG10B 0.55 12.5 0.44 3.26e-32 Bladder cancer; BRCA cis rs9790314 0.779 rs1599376 chr3:160900533 C/G cg03342759 chr3:160939853 NMD3 -0.56 -11.02 -0.4 5.8e-26 Morning vs. evening chronotype; BRCA cis rs6570726 0.791 rs425999 chr6:145819370 C/A cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs4665821 chr2:26309949 A/C cg25036284 chr2:26402008 FAM59B -0.64 -10.67 -0.39 1.37e-24 Gut microbiome composition (summer); BRCA cis rs4911259 0.552 rs62208880 chr20:31463284 T/C cg13636640 chr20:31349939 DNMT3B -0.45 -11.89 -0.43 1.31e-29 Inflammatory bowel disease; BRCA cis rs782590 0.620 rs7596377 chr2:55888612 T/A cg18811423 chr2:55921094 PNPT1 -0.61 -16.91 -0.56 2.61e-53 Metabolic syndrome; BRCA cis rs2576037 0.796 rs2571033 chr18:44578552 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.39 8.02 0.3 5.15e-15 Personality dimensions; BRCA cis rs9733 0.526 rs11204696 chr1:150658721 T/C cg17724175 chr1:150552817 MCL1 0.26 8.53 0.32 1.08e-16 Tonsillectomy; BRCA cis rs113835537 0.529 rs2298806 chr11:66282095 G/A cg24851651 chr11:66362959 CCS 0.44 8.29 0.31 6.92e-16 Airway imaging phenotypes; BRCA cis rs8062405 1.000 rs62036621 chr16:28833299 C/A cg09754948 chr16:28834200 ATXN2L 0.46 9.12 0.34 9.55e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg21573476 chr21:45109991 RRP1B -0.35 -9.33 -0.35 1.68e-19 Mean corpuscular volume; BRCA cis rs7301826 0.651 rs12820597 chr12:131280185 T/C cg11011512 chr12:131303247 STX2 -0.46 -11.32 -0.41 3.49e-27 Plasma plasminogen activator levels; BRCA cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg11663144 chr21:46675770 NA -0.61 -14.0 -0.48 4.75e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9733 0.596 rs11586422 chr1:150679358 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.23 0.31 1.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg10556349 chr10:835070 NA -0.73 -9.86 -0.36 1.84e-21 Eosinophil percentage of granulocytes; BRCA cis rs9814567 0.896 rs1357764 chr3:134344928 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.35 8.27 0.31 8.01e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7584330 0.554 rs77956735 chr2:238399130 C/T cg14458575 chr2:238380390 NA 0.54 8.64 0.32 4.4e-17 Prostate cancer; BRCA cis rs875971 0.540 rs781152 chr7:65479572 T/A cg11764359 chr7:65958608 NA 0.57 11.92 0.43 1e-29 Aortic root size; BRCA cis rs11112613 0.713 rs60865625 chr12:105940256 A/C cg03607813 chr12:105948248 NA 0.6 11.13 0.4 2.09e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs9790314 0.875 rs459515 chr3:161092351 T/C cg03342759 chr3:160939853 NMD3 -0.55 -12.24 -0.44 4.18e-31 Morning vs. evening chronotype; BRCA cis rs7520050 0.966 rs12144263 chr1:46352446 G/A cg24296786 chr1:45957014 TESK2 0.43 9.78 0.36 3.7e-21 Red blood cell count;Reticulocyte count; BRCA cis rs503734 0.502 rs348879 chr3:100979826 A/T cg27318481 chr3:100970896 IMPG2 -0.41 -9.76 -0.36 4.59e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17376456 0.877 rs13165147 chr5:93422214 G/A cg21475434 chr5:93447410 FAM172A 0.69 8.87 0.33 7.13e-18 Diabetic retinopathy; BRCA cis rs6460942 0.915 rs6966791 chr7:12439714 T/C cg10578991 chr7:12443926 VWDE -0.55 -7.86 -0.3 1.69e-14 Coronary artery disease; BRCA cis rs6684514 0.922 rs11264475 chr1:156306918 G/A cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs11608355 0.545 rs9943764 chr12:109905720 G/A cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs7590368 1.000 rs55771723 chr2:10961902 T/C cg15705551 chr2:10952987 PDIA6 0.44 8.09 0.3 3.12e-15 Educational attainment (years of education); BRCA cis rs3768617 0.510 rs2296291 chr1:183079509 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA trans rs35110281 0.748 rs162403 chr21:44963365 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.33 0.38 3.01e-23 Mean corpuscular volume; BRCA cis rs7103648 0.932 rs7104036 chr11:47462140 A/G cg03711944 chr11:47377212 SPI1 -0.42 -11.31 -0.41 3.51e-27 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs62229266 0.804 rs880221 chr21:37420785 C/T cg12218747 chr21:37451666 NA -0.33 -7.92 -0.3 1.05e-14 Mitral valve prolapse; BRCA cis rs9368481 0.729 rs9379950 chr6:26961548 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.34 -12.77 -0.45 1.95e-33 Autism spectrum disorder or schizophrenia; BRCA cis rs7737355 0.947 rs32113 chr5:131049585 G/T cg06307176 chr5:131281290 NA -0.56 -11.81 -0.42 2.9e-29 Life satisfaction; BRCA cis rs7267979 0.744 rs6050464 chr20:25209299 C/A cg08601574 chr20:25228251 PYGB 0.37 8.94 0.33 4.11e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836974 0.897 rs1571709 chr21:40553980 T/C cg11644478 chr21:40555479 PSMG1 0.88 20.91 0.64 2.19e-74 Cognitive function; BRCA cis rs1215050 0.765 rs783947 chr4:99012943 T/C cg05340658 chr4:99064831 C4orf37 -0.49 -11.52 -0.41 4.93e-28 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.09 0.4 2.88e-26 Electroencephalogram traits; BRCA cis rs595982 0.559 rs17206700 chr19:49361255 A/G cg15549821 chr19:49342101 PLEKHA4 -0.7 -11.4 -0.41 1.52e-27 Red cell distribution width; BRCA cis rs8141529 0.504 rs6005915 chr22:29233262 A/G cg15103426 chr22:29168792 CCDC117 0.49 9.86 0.36 1.95e-21 Lymphocyte counts; BRCA cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg21609526 chr1:3105151 PRDM16 0.38 9.19 0.34 5.43e-19 Migraine; BRCA cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg08219700 chr8:58056026 NA 0.57 9.52 0.35 3.35e-20 Developmental language disorder (linguistic errors); BRCA cis rs826838 0.935 rs3886109 chr12:39189243 C/T cg13010199 chr12:38710504 ALG10B 0.53 11.07 0.4 3.38e-26 Heart rate; BRCA cis rs7131987 0.868 rs11050151 chr12:29403008 T/A cg09582351 chr12:29534625 ERGIC2 -0.38 -9.15 -0.34 7.26e-19 QT interval; BRCA cis rs4820539 1.000 rs6003518 chr22:23471533 C/T cg14186256 chr22:23484241 RTDR1 0.77 23.78 0.69 5.1599999999999996e-90 Bone mineral density; BRCA cis rs4332037 0.624 rs56256289 chr7:1892529 C/T cg12432903 chr7:1882776 MAD1L1 0.45 8.06 0.3 3.65e-15 Bipolar disorder; BRCA trans rs1941687 0.509 rs2282632 chr18:31320229 A/G cg27147174 chr7:100797783 AP1S1 -0.44 -8.69 -0.33 3.05e-17 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg00071950 chr4:10020882 SLC2A9 0.56 13.66 0.48 1.77e-37 Bone mineral density; BRCA cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg04414720 chr1:150670196 GOLPH3L 0.36 8.22 0.31 1.15e-15 Tonsillectomy; BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg13628971 chr7:2884303 GNA12 0.48 9.57 0.35 2.33e-20 Height; BRCA cis rs11190604 0.747 rs11190516 chr10:102173525 G/A cg07080220 chr10:102295463 HIF1AN 0.51 10.36 0.38 2.26e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs8062405 0.824 rs7191618 chr16:28565667 C/G cg16576597 chr16:28551801 NUPR1 0.29 8.14 0.31 2.12e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2742234 0.541 rs10899778 chr10:43718509 G/C cg15436174 chr10:43711423 RASGEF1A 0.54 10.65 0.39 1.66e-24 Hirschsprung disease; BRCA cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -18.16 -0.58 1.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs8062405 0.824 rs28772958 chr16:28535305 A/G cg16576597 chr16:28551801 NUPR1 0.28 7.9 0.3 1.26e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs634534 0.622 rs531612 chr11:65705432 C/T cg17985854 chr11:65770987 BANF1;EIF1AD -0.33 -7.91 -0.3 1.11e-14 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs12142240 0.698 rs1057534 chr1:46815880 A/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs6963495 0.818 rs73192125 chr7:105175068 A/C cg19920283 chr7:105172520 RINT1 0.57 10.15 0.37 1.52e-22 Bipolar disorder (body mass index interaction); BRCA cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg22974920 chr21:40686053 BRWD1 -0.37 -8.29 -0.31 6.9e-16 Cognitive function; BRCA cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.9e-19 Lymphocyte counts; BRCA cis rs858239 0.600 rs9691762 chr7:23125922 G/C cg23682824 chr7:23144976 KLHL7 0.46 12.25 0.44 3.7e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs477692 0.673 rs511361 chr10:131365052 C/T cg24747557 chr10:131355152 MGMT -0.36 -8.81 -0.33 1.21e-17 Response to temozolomide; BRCA cis rs1577917 1.000 rs68171315 chr6:86707400 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -7.92 -0.3 1.04e-14 Response to antipsychotic treatment; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg21747090 chr2:27597821 SNX17 -0.37 -7.89 -0.3 1.33e-14 Total body bone mineral density; BRCA cis rs12142240 0.698 rs72677596 chr1:46833930 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.33 -0.35 1.75e-19 Menopause (age at onset); BRCA cis rs9646954 0.542 rs4149505 chr2:101033697 G/A cg14675211 chr2:100938903 LONRF2 0.51 11.11 0.4 2.36e-26 Intelligence (multi-trait analysis); BRCA cis rs10464366 0.544 rs6952466 chr7:39155032 A/T cg18850127 chr7:39170497 POU6F2 0.54 11.59 0.42 2.46e-28 IgG glycosylation; BRCA cis rs7666738 0.830 rs6853266 chr4:99047528 G/T cg17366294 chr4:99064904 C4orf37 0.48 11.05 0.4 4.38e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 0.69 13.18 0.46 2.83e-35 Alzheimer's disease; BRCA cis rs11098499 0.954 rs4309825 chr4:120314881 C/T cg09307838 chr4:120376055 NA -0.72 -15.68 -0.53 4.02e-47 Corneal astigmatism; BRCA cis rs8177253 0.761 rs12490148 chr3:133523973 C/T cg08048268 chr3:133502702 NA -0.42 -10.57 -0.39 3.56e-24 Iron status biomarkers; BRCA cis rs6815814 0.950 rs5743789 chr4:38833173 A/T cg02016764 chr4:38805732 TLR1 -0.51 -8.02 -0.3 5.14e-15 Breast cancer; BRCA cis rs4332037 0.802 rs12113633 chr7:1932936 G/A cg23422044 chr7:1970798 MAD1L1 -0.72 -13.04 -0.46 1.24e-34 Bipolar disorder; BRCA cis rs13004237 1 rs13004237 chr2:172833139 A/G cg13550731 chr2:172543902 DYNC1I2 -0.77 -22.25 -0.66 1.16e-81 Schizophrenia; BRCA trans rs4689592 0.546 rs10937782 chr4:7057106 G/C cg07817883 chr1:32538562 TMEM39B -0.45 -8.73 -0.33 2.18e-17 Monocyte percentage of white cells; BRCA cis rs7805747 0.961 rs55779150 chr7:151406449 A/T cg17611936 chr7:151411526 PRKAG2 0.41 7.91 0.3 1.15e-14 Glomerular filtration rate in non diabetics (creatinine);Chronic kidney disease;Glomerular filtration rate (creatinine); BRCA cis rs875971 1.000 rs12533997 chr7:65965377 A/G cg18876405 chr7:65276391 NA 0.55 13.18 0.46 3.03e-35 Aortic root size; BRCA cis rs798554 0.683 rs1182155 chr7:2902890 C/G cg19346786 chr7:2764209 NA -0.28 -8.95 -0.33 3.76e-18 Height; BRCA cis rs6089829 0.962 rs1116450 chr20:61658210 T/C cg08564027 chr20:61660810 NA 0.86 22.59 0.67 1.77e-83 Prostate cancer (SNP x SNP interaction); BRCA trans rs17685 0.753 rs1637044 chr7:75703744 T/C cg19862616 chr7:65841803 NCRNA00174 0.85 28.25 0.75 1.44e-114 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 8.98 0.33 2.98e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1163251 0.869 rs487884 chr1:120217330 C/T cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs7903847 0.596 rs869967 chr10:99147975 T/C cg08345082 chr10:99160200 RRP12 -0.29 -8.57 -0.32 7.47e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs4363385 0.818 rs529077 chr1:153012149 T/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs2658782 0.950 rs2446061 chr11:93149277 C/T cg15737290 chr11:93063684 CCDC67 0.54 10.29 0.38 4.6e-23 Pulmonary function decline; BRCA cis rs7072216 0.763 rs7909822 chr10:100172035 A/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.5 -0.35 4.12e-20 Metabolite levels; BRCA cis rs2992756 0.663 rs2992753 chr1:18808292 A/C cg05040210 chr1:18807594 KLHDC7A 0.37 7.82 0.3 2.21e-14 Breast cancer; BRCA cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg14349672 chr11:133703707 NA -0.43 -9.58 -0.35 2.09e-20 Childhood ear infection; BRCA cis rs9733 0.596 rs12089989 chr1:150715782 G/A cg18016565 chr1:150552671 MCL1 0.34 8.23 0.31 1.05e-15 Tonsillectomy; BRCA cis rs7666738 0.830 rs1426666 chr4:99030887 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6840360 0.593 rs4696287 chr4:152606723 C/T cg22705602 chr4:152727874 NA -0.38 -10.3 -0.38 4.13e-23 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11644478 chr21:40555479 PSMG1 0.65 14.61 0.5 6.42e-42 Cognitive function; BRCA cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg14829155 chr15:31115871 NA 0.41 8.11 0.31 2.5e-15 Huntington's disease progression; BRCA cis rs9308433 0.529 rs10465697 chr1:214499948 T/C cg06198575 chr1:214491504 SMYD2 0.55 12.1 0.43 1.65e-30 IgG glycosylation; BRCA cis rs7246657 0.882 rs8112610 chr19:37928730 C/A cg14683738 chr19:37701593 ZNF585B 0.44 7.83 0.3 2.1e-14 Coronary artery calcification; BRCA cis rs17641971 0.965 rs341815 chr8:49978424 A/C cg00325661 chr8:49890786 NA 0.31 7.96 0.3 7.89e-15 Blood metabolite levels; BRCA cis rs7666738 0.791 rs1830231 chr4:99026185 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.5 0.57 2.45e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg04267008 chr7:1944627 MAD1L1 -0.61 -13.34 -0.47 5.23e-36 Bipolar disorder and schizophrenia; BRCA cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg08807101 chr21:30365312 RNF160 0.36 7.96 0.3 7.6e-15 Pancreatic cancer; BRCA cis rs6740322 0.643 rs13390381 chr2:43534414 C/A cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.62 -10.77 -0.39 5.64e-25 Coronary artery disease; BRCA cis rs912057 1.000 rs1294410 chr6:6738752 C/T cg06612196 chr6:6737390 NA -0.45 -9.95 -0.37 9.03e-22 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs6733011 0.538 rs10175560 chr2:99465418 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.37 -8.09 -0.3 3.01e-15 Bipolar disorder; BRCA cis rs1443512 0.812 rs1561987 chr12:54335268 C/T cg17410650 chr12:54324560 NA -0.38 -9.31 -0.35 2.06e-19 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs9611565 0.512 rs132767 chr22:42009520 C/T cg03806693 chr22:41940476 POLR3H -1.02 -17.47 -0.57 3.59e-56 Vitiligo; BRCA cis rs6964587 0.773 rs38793 chr7:92027187 A/G cg01689657 chr7:91764605 CYP51A1 -0.23 -7.92 -0.3 1.08e-14 Breast cancer; BRCA cis rs7666738 0.830 rs2865979 chr4:99027137 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.875 rs2180192 chr6:146322284 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -8.7 -0.33 2.85e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4820539 1.000 rs2267002 chr22:23456702 T/C cg14186256 chr22:23484241 RTDR1 0.74 22.59 0.67 1.73e-83 Bone mineral density; BRCA cis rs10045504 0.502 rs72746051 chr5:38759817 G/A cg15396434 chr5:38725168 NA -0.53 -10.21 -0.37 9.28e-23 Night sleep phenotypes; BRCA cis rs1003719 0.715 rs2251952 chr21:38559711 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.56 -12.43 -0.44 6.21e-32 Eye color traits; BRCA cis rs593982 0.777 rs534414 chr11:65475515 A/G cg08755490 chr11:65554678 OVOL1 1.21 17.87 0.58 3.29e-58 Atopic dermatitis; BRCA cis rs6005807 0.719 rs134524 chr22:28773804 G/A cg12565055 chr22:29076175 TTC28 -0.43 -7.83 -0.3 2.09e-14 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs61931739 0.534 rs11052960 chr12:33997754 A/T cg06521331 chr12:34319734 NA -0.62 -11.13 -0.4 2.05e-26 Morning vs. evening chronotype; BRCA cis rs2204008 0.692 rs11613378 chr12:38213138 T/A cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs877529 0.967 rs139411 chr22:39552888 A/G cg18708252 chr22:39545030 CBX7 -0.31 -8.17 -0.31 1.61e-15 Multiple myeloma; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.7 0.61 7.37e-68 Platelet count; BRCA cis rs17345786 0.798 rs9817043 chr3:101281852 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.43 9.3 0.35 2.29e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.962 rs7273930 chr20:61666017 G/A cg08045932 chr20:61659980 NA 0.5 11.49 0.41 6.62e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg01689657 chr7:91764605 CYP51A1 -0.22 -7.83 -0.3 2e-14 Breast cancer; BRCA cis rs7772486 0.790 rs2253764 chr6:146199881 T/A cg23711669 chr6:146136114 FBXO30 0.71 17.08 0.56 3.5e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6580649 0.882 rs2286022 chr12:48436647 G/A cg05342945 chr12:48394962 COL2A1 0.43 8.08 0.3 3.3e-15 Lung cancer; BRCA cis rs2239547 0.603 rs6789219 chr3:53098938 C/G cg11645453 chr3:52864694 ITIH4 0.39 9.18 0.34 5.99e-19 Schizophrenia; BRCA cis rs875971 0.545 rs801199 chr7:66025273 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.76 -0.36 4.55e-21 Aortic root size; BRCA cis rs7760949 0.852 rs9475801 chr6:13933115 G/A cg27413430 chr6:13925136 RNF182 0.46 9.22 0.34 4.18e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg15017067 chr4:17643749 FAM184B 0.34 10.6 0.39 2.63e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7412746 0.658 rs12410394 chr1:150860186 G/A cg15448220 chr1:150897856 SETDB1 0.35 7.87 0.3 1.52e-14 Melanoma; BRCA cis rs524281 0.861 rs7941431 chr11:65960157 C/T cg16950941 chr11:66035639 RAB1B -0.38 -8.0 -0.3 6.03e-15 Electroencephalogram traits; BRCA cis rs11098499 0.863 rs13134665 chr4:120426430 T/C cg09307838 chr4:120376055 NA 0.7 14.21 0.49 4.82e-40 Corneal astigmatism; BRCA cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.51 8.43 0.32 2.23e-16 Renal function-related traits (BUN); BRCA cis rs854765 0.647 rs4426402 chr17:17977926 C/T cg04398451 chr17:18023971 MYO15A 0.72 17.12 0.56 2.3e-54 Total body bone mineral density; BRCA cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 15.61 0.53 9.12e-47 Colorectal cancer; BRCA cis rs2505998 1.000 rs1864410 chr10:43575625 T/G cg15436174 chr10:43711423 RASGEF1A -0.43 -8.43 -0.32 2.25e-16 Hirschsprung disease; BRCA cis rs79976124 0.837 rs10455591 chr6:66650584 A/G cg07460842 chr6:66804631 NA 0.6 10.37 0.38 2.13e-23 Type 2 diabetes; BRCA cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg19539972 chr4:7069911 GRPEL1 0.67 16.65 0.55 5.4e-52 Monocyte percentage of white cells; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg13139843 chr21:31852793 KRTAP19-1 0.33 7.98 0.3 6.99e-15 HDL cholesterol; BRCA cis rs6433895 0.677 rs72887083 chr2:181999530 A/G cg00481216 chr2:181971175 NA 0.46 8.68 0.32 3.35e-17 Lymphocyte counts; BRCA trans rs1422110 0.718 rs10079231 chr5:85439369 A/G cg01787110 chr1:109008453 NBPF6 0.42 8.97 0.33 3.18e-18 Attention function in attention deficit hyperactive disorder; BRCA cis rs701145 0.529 rs355746 chr3:153961627 C/G cg16511985 chr3:153974050 SGEF 0.45 10.33 0.38 3.18e-23 Coronary artery disease; BRCA cis rs9653442 0.675 rs7605430 chr2:100647552 C/G cg22139774 chr2:100720529 AFF3 0.27 8.01 0.3 5.53e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs7628448 chr3:10146828 G/A cg00166722 chr3:10149974 C3orf24 0.67 12.75 0.45 2.45e-33 Alzheimer's disease; BRCA cis rs9325144 0.723 rs3887436 chr12:39189526 A/C cg26384229 chr12:38710491 ALG10B -0.51 -11.36 -0.41 2.3e-27 Morning vs. evening chronotype; BRCA cis rs3772130 0.962 rs9856641 chr3:121566859 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.76 0.39 6.04e-25 Cognitive performance; BRCA cis rs72781680 0.898 rs56303870 chr2:24086944 G/A cg08917208 chr2:24149416 ATAD2B 0.91 13.42 0.47 2.48e-36 Lymphocyte counts; BRCA cis rs7572733 0.555 rs13395030 chr2:198750806 A/G cg00792783 chr2:198669748 PLCL1 0.47 10.25 0.38 6.42e-23 Dermatomyositis; BRCA cis rs2075671 0.810 rs12531792 chr7:100280624 G/A cg16850897 chr7:100343110 ZAN -0.59 -12.31 -0.44 2.19e-31 Other erythrocyte phenotypes; BRCA cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg05347473 chr6:146136440 FBXO30 0.4 8.13 0.31 2.28e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs765787 0.530 rs2433227 chr15:45517119 A/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA cis rs2797160 1.000 rs4897152 chr6:126002400 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.45 -0.35 6.5e-20 Endometrial cancer; BRCA trans rs6089829 0.851 rs6122346 chr20:61661822 C/G cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs10208940 0.920 rs6742045 chr2:68811850 G/A cg12452813 chr2:68675892 NA 0.49 8.52 0.32 1.15e-16 Urate levels in lean individuals; BRCA cis rs875971 0.522 rs1701760 chr7:65473688 A/G cg18876405 chr7:65276391 NA 0.7 18.19 0.58 7.1e-60 Aortic root size; BRCA cis rs796364 0.806 rs112305133 chr2:201010380 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.53 -8.62 -0.32 5.23e-17 Schizophrenia; BRCA cis rs10193935 0.792 rs13430031 chr2:42499968 C/T cg27598129 chr2:42591480 NA -0.89 -14.19 -0.49 6.22e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs611744 0.669 rs13251024 chr8:109258333 T/C cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.13e-15 Dupuytren's disease; BRCA cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg21770322 chr7:97807741 LMTK2 0.41 11.03 0.4 5.28e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs6701037 0.566 rs13373754 chr1:175139275 C/A cg00321850 chr1:175162397 KIAA0040 0.42 12.08 0.43 2e-30 Alcohol dependence; BRCA cis rs798554 0.683 rs1636264 chr7:2864586 G/T cg04166393 chr7:2884313 GNA12 0.5 10.37 0.38 2.19e-23 Height; BRCA cis rs3806843 0.966 rs10036519 chr5:140151701 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.38 0.35 1.13e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs7666738 0.830 rs10019087 chr4:99030211 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3862030 0.694 rs12781742 chr10:104227469 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.13 -0.43 1.25e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA trans rs61931739 0.500 rs2389269 chr12:34034179 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.51 0.35 3.84e-20 Morning vs. evening chronotype; BRCA cis rs514406 0.861 rs11206011 chr1:53235910 T/C cg08859206 chr1:53392774 SCP2 0.48 10.78 0.39 5.03e-25 Monocyte count; BRCA cis rs7249142 0.549 rs2239369 chr19:19292405 A/T cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B 0.45 10.82 0.39 3.71e-25 IgG glycosylation; BRCA cis rs13108904 0.936 rs4974540 chr4:1213463 C/T cg05665937 chr4:1216051 CTBP1 0.52 10.95 0.4 1.07e-25 Obesity-related traits; BRCA cis rs2072438 0.503 rs2146838 chr9:123876305 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.39 -7.85 -0.3 1.72e-14 Rheumatoid arthritis; BRCA trans rs12310956 0.532 rs6488187 chr12:33975029 C/T cg26384229 chr12:38710491 ALG10B 0.51 11.1 0.4 2.57e-26 Morning vs. evening chronotype; BRCA cis rs13064411 0.696 rs6773497 chr3:113186514 T/C cg18753928 chr3:113234510 CCDC52 -0.55 -11.48 -0.41 7.08e-28 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.93 0.33 4.64e-18 Tonsillectomy; BRCA cis rs12477438 0.871 rs13396584 chr2:99611768 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.64 12.42 0.44 7.32e-32 Chronic sinus infection; BRCA cis rs79976124 0.797 rs77895756 chr6:66626782 C/T cg07460842 chr6:66804631 NA 0.6 10.2 0.37 1.01e-22 Type 2 diabetes; BRCA cis rs4363385 0.818 rs678960 chr1:153011621 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs1005277 0.505 rs7069702 chr10:38247359 G/T cg00409905 chr10:38381863 ZNF37A 0.5 10.71 0.39 9.56e-25 Extrinsic epigenetic age acceleration; BRCA cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg08975724 chr8:8085496 FLJ10661 0.45 9.1 0.34 1.13e-18 Mood instability; BRCA cis rs10193935 0.792 rs10204778 chr2:42498121 G/T cg27598129 chr2:42591480 NA -0.9 -14.14 -0.49 1.1e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.735 rs351756 chr6:109538773 A/G cg21918786 chr6:109611834 NA 0.36 9.52 0.35 3.45e-20 Reticulocyte fraction of red cells; BRCA cis rs7249142 0.562 rs11085253 chr19:19277517 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.53 -11.45 -0.41 9.7e-28 IgG glycosylation; BRCA cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg21573476 chr21:45109991 RRP1B -0.37 -9.4 -0.35 9.61e-20 Mean corpuscular volume; BRCA trans rs11976180 1.000 rs2951354 chr7:143761001 G/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.26 -0.31 8.66e-16 Obesity-related traits; BRCA cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg11833968 chr6:79620685 NA -0.45 -10.21 -0.37 8.67e-23 Intelligence (multi-trait analysis); BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg16606324 chr3:10149918 C3orf24 0.56 10.99 0.4 7.61e-26 Alzheimer's disease; BRCA trans rs9858542 0.953 rs11719996 chr3:49525958 T/C cg21659725 chr3:3221576 CRBN -0.47 -9.99 -0.37 6.41e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9814567 1.000 rs1880377 chr3:134270468 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 1.000 rs116444534 chr8:58181915 A/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.63 -0.36 1.34e-20 Developmental language disorder (linguistic errors); BRCA cis rs796364 0.806 rs34510964 chr2:201010676 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.52 -8.45 -0.32 1.96e-16 Schizophrenia; BRCA cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.49 0.38 7.33e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs736408 0.677 rs678 chr3:52820981 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 9.16 0.34 6.84e-19 Bipolar disorder; BRCA cis rs7772486 0.754 rs6906258 chr6:146089356 A/G cg13319975 chr6:146136371 FBXO30 0.44 10.31 0.38 3.74e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs524281 0.861 rs6591208 chr11:65949689 A/C cg16950941 chr11:66035639 RAB1B -0.37 -7.82 -0.3 2.14e-14 Electroencephalogram traits; BRCA cis rs6831352 0.879 rs17218003 chr4:100054723 G/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs9547692 0.938 rs7333607 chr13:37462010 A/G cg01493522 chr13:37497338 NA -0.4 -8.26 -0.31 8.34e-16 Coronary artery disease; BRCA cis rs34779708 0.931 rs66887762 chr10:35330577 C/T cg03585969 chr10:35415529 CREM 0.56 11.6 0.42 2.32e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17401966 0.540 rs11121557 chr1:10448260 T/G cg03954927 chr1:10346856 KIF1B 0.34 10.15 0.37 1.46e-22 Hepatocellular carcinoma; BRCA trans rs3733585 0.673 rs9994266 chr4:9954450 C/T cg26043149 chr18:55253948 FECH -0.38 -8.47 -0.32 1.66e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg01017244 chr2:74357527 NA 0.61 12.65 0.45 6.76e-33 Gestational age at birth (maternal effect); BRCA cis rs9790314 0.521 rs1376122 chr3:161087857 A/G cg04691961 chr3:161091175 C3orf57 -0.46 -10.85 -0.39 2.66e-25 Morning vs. evening chronotype; BRCA cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg11266682 chr4:10021025 SLC2A9 0.45 12.02 0.43 3.9e-30 Bone mineral density; BRCA cis rs3741404 0.583 rs640999 chr11:63869425 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.38 9.08 0.34 1.38e-18 Platelet count; BRCA cis rs4363385 0.782 rs310105 chr1:153022253 A/G cg24667326 chr1:152973720 SPRR3 -0.31 -8.29 -0.31 6.61e-16 Inflammatory skin disease; BRCA cis rs12579753 0.917 rs12316644 chr12:82205497 C/T cg07988820 chr12:82153109 PPFIA2 0.51 8.81 0.33 1.2e-17 Resting heart rate; BRCA cis rs1862618 0.671 rs28397234 chr5:56248428 T/G cg20203395 chr5:56204925 C5orf35 0.39 8.57 0.32 7.72e-17 Initial pursuit acceleration; BRCA trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg06606381 chr12:133084897 FBRSL1 -0.77 -8.04 -0.3 4.34e-15 Intelligence (multi-trait analysis); BRCA cis rs2806561 1.000 rs2746553 chr1:23493246 T/C cg19743168 chr1:23544995 NA 0.4 9.63 0.36 1.36e-20 Height; BRCA cis rs7772486 0.686 rs7739735 chr6:146123536 G/A cg13319975 chr6:146136371 FBXO30 -0.34 -7.91 -0.3 1.1e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs8051149 0.652 rs9926829 chr16:87883089 A/G cg01412419 chr16:87856264 NA -0.44 -9.29 -0.34 2.48e-19 Blood metabolite levels; BRCA cis rs17711722 0.727 rs781151 chr7:65479878 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.41 8.9 0.33 5.6e-18 Calcium levels; BRCA cis rs3096299 0.838 rs4785561 chr16:89429052 C/T cg06640241 chr16:89574553 SPG7 0.47 8.71 0.33 2.55e-17 Multiple myeloma (IgH translocation); BRCA cis rs826838 0.754 rs2387920 chr12:38626351 A/G cg26384229 chr12:38710491 ALG10B 0.78 18.0 0.58 6.47e-59 Heart rate; BRCA cis rs6484504 0.576 rs208090 chr11:31190992 T/C cg26647111 chr11:31128758 NA -0.44 -9.61 -0.36 1.65e-20 Red blood cell count; BRCA cis rs1975991 0.711 rs1479934 chr3:187966553 A/G cg15417654 chr3:187959138 LPP 0.33 8.36 0.31 3.94e-16 White matter integrity (bipolar disorder risk interaction); BRCA cis rs56235845 0.694 rs11749830 chr5:176766547 G/A cg16006841 chr5:176797999 RGS14 0.61 11.82 0.42 2.64e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg05340658 chr4:99064831 C4orf37 0.59 12.13 0.43 1.33e-30 Colonoscopy-negative controls vs population controls; BRCA trans rs2797160 1.000 rs6933471 chr6:126017029 T/G cg05039488 chr6:79577232 IRAK1BP1 0.35 7.88 0.3 1.4e-14 Endometrial cancer; BRCA cis rs3784262 0.565 rs1899355 chr15:58286989 C/T cg12031962 chr15:58353849 ALDH1A2 -0.33 -8.49 -0.32 1.4e-16 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg12310025 chr6:25882481 NA -0.41 -9.94 -0.37 9.63e-22 Height; BRCA cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.3 -0.35 2.28e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs495337 0.760 rs6125825 chr20:48553703 A/G cg17835207 chr20:48524531 SPATA2 -0.67 -16.65 -0.55 5.78e-52 Psoriasis; BRCA cis rs6963495 0.818 rs114865717 chr7:105158526 C/T cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs8141797 0.901 rs17004848 chr22:24538918 C/T cg00411358 chr22:24577142 SUSD2 -0.66 -8.35 -0.31 4.15e-16 Amyotrophic lateral sclerosis;Coronary artery disease; BRCA cis rs5997397 0.934 rs6005863 chr22:29156448 A/G cg15103426 chr22:29168792 CCDC117 0.48 11.83 0.42 2.56e-29 Red cell distribution width; BRCA trans rs747782 0.585 rs1604655 chr11:48274778 G/A cg15704280 chr7:45808275 SEPT13 0.52 7.97 0.3 7.45e-15 Intraocular pressure; BRCA cis rs3845702 0.866 rs3914458 chr2:180862606 A/G cg01881094 chr2:180872142 CWC22 -0.65 -13.58 -0.47 4.19e-37 Schizophrenia; BRCA cis rs10751667 0.666 rs7395823 chr11:942701 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs7772486 0.686 rs4896827 chr6:145953338 T/A cg05347473 chr6:146136440 FBXO30 0.39 7.86 0.3 1.66e-14 Lobe attachment (rater-scored or self-reported); BRCA trans rs6479891 1.000 rs868798 chr10:64895010 A/G cg14819942 chr15:35414228 NA 0.34 8.51 0.32 1.2e-16 Arthritis (juvenile idiopathic); BRCA cis rs10782582 0.546 rs79652169 chr1:76233882 G/A cg03433033 chr1:76189801 ACADM -0.45 -9.25 -0.34 3.36e-19 Daytime sleep phenotypes; BRCA cis rs9291683 0.530 rs11723591 chr4:9985398 T/A cg11266682 chr4:10021025 SLC2A9 0.41 10.81 0.39 3.89e-25 Bone mineral density; BRCA cis rs3858526 0.883 rs7481882 chr11:5944221 A/G cg13902645 chr11:5959945 NA -0.52 -10.87 -0.4 2.2e-25 DNA methylation (variation); BRCA cis rs600806 0.888 rs3853500 chr1:109864269 T/C cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.5e-15 Intelligence (multi-trait analysis); BRCA cis rs1018836 0.923 rs7840846 chr8:91565501 T/A cg16814680 chr8:91681699 NA -0.64 -14.26 -0.49 2.9e-40 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs7552404 0.731 rs6699682 chr1:76340123 A/G cg10523679 chr1:76189770 ACADM -0.63 -11.77 -0.42 4.25e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs3812831 0.669 rs7327370 chr13:114946858 A/G cg15513719 chr13:114904418 NA 0.43 8.21 0.31 1.2e-15 Schizophrenia; BRCA cis rs17376456 0.877 rs7702521 chr5:93484579 G/T cg21475434 chr5:93447410 FAM172A 0.68 8.7 0.33 2.86e-17 Diabetic retinopathy; BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.95 0.33 3.76e-18 Tonsillectomy; BRCA trans rs7824557 0.569 rs35418978 chr8:11186453 T/C cg15556689 chr8:8085844 FLJ10661 0.34 9.19 0.34 5.38e-19 Retinal vascular caliber; BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg01262667 chr19:19385393 TM6SF2 0.43 11.05 0.4 4.1e-26 Tonsillectomy; BRCA cis rs490234 0.651 rs13301073 chr9:128284378 G/A cg14078157 chr9:128172775 NA -0.53 -11.76 -0.42 4.68e-29 Mean arterial pressure; BRCA cis rs651907 0.535 rs17412601 chr3:101499275 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.58 0.47 4.49e-37 Colorectal cancer; BRCA cis rs4722166 0.598 rs7804146 chr7:22800929 C/G cg05472934 chr7:22766657 IL6 0.39 9.69 0.36 8.21e-21 Lung cancer; BRCA trans rs9951602 0.512 rs12607561 chr18:76644284 G/A cg02800362 chr5:177631904 HNRNPAB 0.75 17.49 0.57 2.96e-56 Obesity-related traits; BRCA cis rs6484504 0.576 rs11031320 chr11:31242545 C/T cg14844989 chr11:31128820 NA -0.45 -9.7 -0.36 7.9e-21 Red blood cell count; BRCA trans rs11098499 0.775 rs2002049 chr4:120257417 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.62 0.39 2.31e-24 Corneal astigmatism; BRCA cis rs4481887 0.893 rs10788774 chr1:248471712 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.85 0.33 8.5e-18 Common traits (Other); BRCA cis rs372883 0.638 rs371432 chr21:30710876 G/A cg24692254 chr21:30365293 RNF160 -0.46 -10.32 -0.38 3.45e-23 Pancreatic cancer; BRCA cis rs7737355 0.945 rs245801 chr5:130666955 T/C cg06307176 chr5:131281290 NA -0.46 -9.04 -0.34 1.88e-18 Life satisfaction; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg08061076 chr7:1943177 MAD1L1 -0.35 -7.97 -0.3 7.13e-15 Bipolar disorder and schizophrenia; BRCA cis rs2204008 0.641 rs2387810 chr12:38368875 G/T cg26384229 chr12:38710491 ALG10B 0.73 17.03 0.56 6.96e-54 Bladder cancer; BRCA cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg18132916 chr6:79620363 NA -0.48 -10.78 -0.39 5.12e-25 Intelligence (multi-trait analysis); BRCA cis rs478304 0.934 rs509206 chr11:65493807 C/T cg08755490 chr11:65554678 OVOL1 0.46 9.16 0.34 7.21e-19 Acne (severe); BRCA cis rs4820539 0.966 rs2267000 chr22:23455366 A/G cg14186256 chr22:23484241 RTDR1 0.74 22.31 0.66 5.84e-82 Bone mineral density; BRCA cis rs73242632 1.000 rs73242622 chr4:57818564 C/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.65 7.93 0.3 9.85e-15 Congenital heart disease (maternal effect); BRCA cis rs7258465 1.000 rs4808801 chr19:18571141 A/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.52 -0.32 1.13e-16 Breast cancer; BRCA cis rs41005 0.967 rs1974696 chr2:8115782 A/G cg03155496 chr2:8117019 LOC339788 0.63 18.17 0.58 8.7e-60 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg24812749 chr6:127587940 RNF146 0.88 20.87 0.64 3.85e-74 Breast cancer; BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 0.66 12.81 0.45 1.37e-33 Alzheimer's disease; BRCA cis rs8114671 0.562 rs2223881 chr20:33506463 A/C cg24642439 chr20:33292090 TP53INP2 0.41 8.1 0.31 2.71e-15 Height; BRCA trans rs35110281 0.712 rs8133523 chr21:45062403 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.46 0.38 9.36e-24 Mean corpuscular volume; BRCA cis rs561341 1.000 rs72823789 chr17:30284084 G/A cg23018236 chr17:30244563 NA -0.68 -10.6 -0.39 2.7e-24 Hip circumference adjusted for BMI; BRCA cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg08027265 chr7:2291960 NA -0.35 -8.11 -0.31 2.66e-15 Bipolar disorder and schizophrenia; BRCA cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg09184832 chr6:79620586 NA -0.53 -11.72 -0.42 6.96e-29 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs747050 chr19:19584987 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.89 0.43 1.31e-29 Tonsillectomy; BRCA cis rs2180341 0.920 rs4472373 chr6:127705983 G/A cg24812749 chr6:127587940 RNF146 0.87 19.99 0.62 2.03e-69 Breast cancer; BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.88 15.64 0.53 6.44e-47 Platelet count; BRCA cis rs875971 1.000 rs6460295 chr7:65882728 T/C cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.33e-67 Aortic root size; BRCA cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg16006841 chr5:176797999 RGS14 0.61 11.88 0.43 1.57e-29 Hemoglobin concentration;Hematocrit; BRCA cis rs763121 0.819 rs5757237 chr22:39073835 G/C cg06022373 chr22:39101656 GTPBP1 0.73 17.6 0.57 7.85e-57 Menopause (age at onset); BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg08219700 chr8:58056026 NA 0.57 9.4 0.35 9.75e-20 Developmental language disorder (linguistic errors); BRCA cis rs12701220 0.696 rs12112029 chr7:1137889 G/A cg00990874 chr7:1149470 C7orf50 -0.6 -12.17 -0.43 8.99e-31 Bronchopulmonary dysplasia; BRCA cis rs7633770 0.805 rs12330414 chr3:46662428 T/C cg11219411 chr3:46661640 NA 0.73 21.1 0.64 2.2e-75 Coronary artery disease; BRCA cis rs1843834 0.539 rs3912999 chr2:225390089 C/T cg12698349 chr2:225449008 CUL3 0.61 12.61 0.45 1.06e-32 IgE levels in asthmatics (D.p. specific); BRCA cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA trans rs2204008 0.522 rs12370263 chr12:38113311 A/G cg06521331 chr12:34319734 NA -0.54 -9.94 -0.37 9.45e-22 Bladder cancer; BRCA cis rs1707322 0.789 rs7540578 chr1:46252144 C/T cg03146154 chr1:46216737 IPP 0.5 11.15 0.4 1.67e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg04025307 chr7:1156635 C7orf50 0.5 11.83 0.42 2.55e-29 Longevity;Endometriosis; BRCA cis rs523522 0.962 rs3742052 chr12:120966921 A/G cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.5e-36 High light scatter reticulocyte count; BRCA cis rs7264396 0.563 rs2425089 chr20:34304036 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.05e-30 Total cholesterol levels; BRCA cis rs724568 0.565 rs13405830 chr2:67952260 A/G cg17945962 chr2:67939740 NA -0.37 -9.75 -0.36 5.01e-21 Major depressive disorder (broad); BRCA cis rs10267417 0.603 rs36077006 chr7:19933853 A/G cg05791153 chr7:19748676 TWISTNB 0.43 8.17 0.31 1.6e-15 Night sleep phenotypes; BRCA cis rs2153535 0.601 rs9505472 chr6:8538765 T/C cg07606381 chr6:8435919 SLC35B3 0.64 13.99 0.48 5.5e-39 Motion sickness; BRCA cis rs10838687 0.800 rs4752977 chr11:47300429 T/C cg25783544 chr11:47291846 MADD 0.41 7.96 0.3 7.98e-15 Proinsulin levels; BRCA cis rs17711722 0.740 rs7809991 chr7:65406218 A/G cg11764359 chr7:65958608 NA 0.62 13.46 0.47 1.49e-36 Calcium levels; BRCA cis rs7617773 0.780 rs36075665 chr3:48343087 C/T cg11946769 chr3:48343235 NME6 0.68 13.81 0.48 3.66e-38 Coronary artery disease; BRCA cis rs853679 0.517 rs9368556 chr6:28131153 T/C cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg18404041 chr3:52824283 ITIH1 -0.47 -13.93 -0.48 1.01e-38 Bipolar disorder; BRCA cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.52 8.5 0.32 1.38e-16 Renal function-related traits (BUN); BRCA cis rs9287719 0.578 rs10175555 chr2:10703233 T/C cg00105475 chr2:10696890 NA 0.46 10.13 0.37 1.77e-22 Prostate cancer; BRCA cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg14863265 chr7:2801509 GNA12 -0.36 -8.11 -0.31 2.67e-15 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs4363385 0.747 rs4845507 chr1:152968414 T/G cg24667326 chr1:152973720 SPRR3 -0.36 -9.89 -0.36 1.54e-21 Inflammatory skin disease; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 18.57 0.59 7.14e-62 Alzheimer's disease; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg16145915 chr7:1198662 ZFAND2A -0.64 -15.72 -0.53 2.43e-47 Longevity;Endometriosis; BRCA trans rs17685 0.753 rs1859791 chr7:75786043 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs66887589 0.934 rs41464847 chr4:120532401 A/G cg09307838 chr4:120376055 NA -0.42 -8.79 -0.33 1.36e-17 Diastolic blood pressure; BRCA cis rs425277 0.628 rs262668 chr1:2082602 A/G cg19257562 chr1:2043853 PRKCZ -0.34 -9.02 -0.34 2.13e-18 Height; BRCA cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg06550200 chr5:1325588 CLPTM1L -0.63 -13.08 -0.46 7.94e-35 Lung cancer; BRCA cis rs9486715 0.867 rs2499774 chr6:97006581 C/G cg06623918 chr6:96969491 KIAA0776 -0.92 -27.27 -0.73 3.36e-109 Headache; BRCA cis rs1712517 0.771 rs11191654 chr10:105077124 C/A cg05636881 chr10:105038444 INA 0.35 7.99 0.3 6.39e-15 Migraine; BRCA cis rs12200560 0.505 rs211174 chr6:97071120 C/T cg06623918 chr6:96969491 KIAA0776 0.51 12.03 0.43 3.35e-30 Coronary heart disease; BRCA cis rs7617773 0.780 rs7645425 chr3:48362369 A/T cg11946769 chr3:48343235 NME6 0.67 13.64 0.47 2.37e-37 Coronary artery disease; BRCA cis rs360798 0.512 rs2539978 chr2:63195179 T/C cg17519650 chr2:63277830 OTX1 0.39 8.58 0.32 7.09e-17 Coronary artery disease; BRCA cis rs4689388 0.853 rs11729672 chr4:6293838 A/G cg00701064 chr4:6280414 WFS1 0.68 17.62 0.57 5.96e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs72772090 0.539 rs111237997 chr5:96114953 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.15 -0.43 9.97e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6942756 1.000 rs6974155 chr7:128914545 C/G cg02491457 chr7:128862824 NA -0.69 -13.88 -0.48 1.72e-38 White matter hyperintensity burden; BRCA cis rs490234 0.676 rs13293034 chr9:128256951 C/T cg14078157 chr9:128172775 NA -0.53 -11.75 -0.42 5.48e-29 Mean arterial pressure; BRCA cis rs7727544 0.735 rs274559 chr5:131720070 A/G cg07395648 chr5:131743802 NA 0.36 9.08 0.34 1.38e-18 Blood metabolite levels; BRCA cis rs10876993 0.855 rs1678520 chr12:58049319 C/G cg00677455 chr12:58241039 CTDSP2 -0.35 -7.89 -0.3 1.29e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs9486715 0.830 rs2475023 chr6:96996833 G/A cg06623918 chr6:96969491 KIAA0776 -0.92 -27.15 -0.73 1.65e-108 Headache; BRCA cis rs2625529 0.652 rs9302260 chr15:72174611 T/C cg16672083 chr15:72433130 SENP8 0.66 15.65 0.53 5.83e-47 Red blood cell count; BRCA cis rs6598955 0.671 rs11247884 chr1:26577338 C/T cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs9309711 0.922 rs13385119 chr2:3484521 G/A cg16153549 chr2:3496821 NA -0.41 -9.58 -0.35 2.16e-20 Neurofibrillary tangles; BRCA cis rs8180040 0.676 rs11130114 chr3:47154651 T/G cg16586182 chr3:47516702 SCAP -0.56 -12.9 -0.45 5.05e-34 Colorectal cancer; BRCA cis rs7493 0.950 rs17879277 chr7:95030632 A/C cg01874867 chr7:94954059 PON1 -0.39 -7.81 -0.3 2.29e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2836974 0.605 rs2836971 chr21:40652040 A/C cg17971929 chr21:40555470 PSMG1 -0.62 -14.45 -0.5 3.61e-41 Cognitive function; BRCA cis rs7772486 0.875 rs10457796 chr6:146416087 T/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.78 -0.33 1.51e-17 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.517 rs4104182 chr12:34081343 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.66 0.36 1.08e-20 Morning vs. evening chronotype; BRCA cis rs7737355 0.947 rs10477736 chr5:130922125 T/C cg06307176 chr5:131281290 NA 0.53 10.34 0.38 2.89e-23 Life satisfaction; BRCA cis rs71636778 0.543 rs11810321 chr1:27220521 T/G cg12203394 chr1:27248618 NUDC 0.62 9.59 0.35 1.92e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg18016565 chr1:150552671 MCL1 0.34 8.12 0.31 2.43e-15 Tonsillectomy; BRCA cis rs10733682 0.659 rs13287548 chr9:129466456 C/T cg00232160 chr9:129468157 NA 0.41 9.51 0.35 3.92e-20 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs6121246 0.609 rs2377317 chr20:30402502 A/G cg13852791 chr20:30311386 BCL2L1 -0.84 -18.3 -0.59 1.81e-60 Mean corpuscular hemoglobin; BRCA cis rs7927771 0.793 rs3740686 chr11:47376363 A/G cg20307385 chr11:47447363 PSMC3 0.41 8.56 0.32 8.72e-17 Subjective well-being; BRCA cis rs6860806 0.507 rs2631371 chr5:131703691 G/A cg07395648 chr5:131743802 NA 0.38 8.28 0.31 7.37e-16 Breast cancer; BRCA cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7582180 0.614 rs6737217 chr2:101006267 T/G cg14675211 chr2:100938903 LONRF2 0.48 10.75 0.39 7.13e-25 Intelligence (multi-trait analysis); BRCA cis rs9435341 0.965 rs1335053 chr1:107622823 C/T cg09367891 chr1:107599246 PRMT6 -0.56 -10.08 -0.37 2.81e-22 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg18402987 chr7:1209562 NA 0.51 9.77 0.36 4.11e-21 Longevity;Endometriosis; BRCA cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg13319975 chr6:146136371 FBXO30 -0.39 -8.9 -0.33 5.92e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs1059312 0.932 rs11059916 chr12:129287609 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.37 -0.52 1.43e-45 Systemic lupus erythematosus; BRCA cis rs4787491 0.765 rs4788216 chr16:30048077 C/G cg06326092 chr16:30034487 C16orf92 0.38 9.92 0.37 1.16e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.954 rs28429722 chr4:120300093 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA trans rs6952808 0.656 rs11764212 chr7:2067593 C/A cg04565464 chr8:145669602 NFKBIL2 0.4 9.09 0.34 1.25e-18 Bipolar disorder and schizophrenia; BRCA cis rs6424115 0.679 rs2076345 chr1:24083494 C/T cg15997130 chr1:24165203 NA -0.45 -9.96 -0.37 8.32e-22 Immature fraction of reticulocytes; BRCA cis rs61931739 0.500 rs7310576 chr12:34474735 T/C cg06521331 chr12:34319734 NA -0.5 -9.57 -0.35 2.24e-20 Morning vs. evening chronotype; BRCA cis rs10046574 0.831 rs17479687 chr7:135074833 C/G cg27474649 chr7:135195673 CNOT4 0.57 8.42 0.32 2.49e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1372520 0.577 rs1811443 chr4:90747883 G/C cg15133208 chr4:90757351 SNCA -0.39 -8.05 -0.3 4.1e-15 Neuroticism; BRCA cis rs875971 1.000 rs709597 chr7:65825983 A/G cg18876405 chr7:65276391 NA -0.56 -13.13 -0.46 4.95e-35 Aortic root size; BRCA cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg16339924 chr4:17578868 LAP3 0.62 15.33 0.52 2.18e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg21782813 chr7:2030301 MAD1L1 -0.38 -11.24 -0.41 7.05e-27 Bipolar disorder and schizophrenia; BRCA cis rs17376456 1.000 rs34854140 chr5:93538169 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 7.83 0.3 1.99e-14 Diabetic retinopathy; BRCA cis rs7851660 0.967 rs7049054 chr9:100599969 T/G cg13688889 chr9:100608707 NA -0.36 -8.61 -0.32 5.84e-17 Strep throat; BRCA cis rs9325144 0.555 rs2387843 chr12:38711203 T/C cg13010199 chr12:38710504 ALG10B 0.36 8.31 0.31 5.87e-16 Morning vs. evening chronotype; BRCA cis rs7766436 0.614 rs2073030 chr6:22569634 A/T cg13666174 chr6:22585274 NA -0.4 -8.91 -0.33 5.33e-18 Coronary artery disease; BRCA cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -12.81 -0.45 1.39e-33 Bipolar disorder; BRCA cis rs7618501 0.573 rs7634917 chr3:50049299 T/G cg24110177 chr3:50126178 RBM5 0.36 9.72 0.36 6.3e-21 Intelligence (multi-trait analysis); BRCA cis rs12618769 0.656 rs3820943 chr2:99123177 G/C cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs7264396 0.790 rs6058290 chr20:34247702 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.89 -0.53 3.7e-48 Total cholesterol levels; BRCA trans rs7824557 0.701 rs4568582 chr8:11160495 A/T cg15556689 chr8:8085844 FLJ10661 0.38 9.07 0.34 1.4e-18 Retinal vascular caliber; BRCA cis rs7267979 1.000 rs2424716 chr20:25423538 G/A cg08601574 chr20:25228251 PYGB 0.34 8.22 0.31 1.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6748734 0.894 rs4675869 chr2:241827696 A/G cg02820040 chr2:241836501 C2orf54 -0.53 -10.24 -0.38 7e-23 Urinary metabolites; BRCA cis rs875971 0.862 rs6460302 chr7:65960257 C/G cg18876405 chr7:65276391 NA 0.5 11.33 0.41 3.02e-27 Aortic root size; BRCA cis rs9527 0.501 rs12244388 chr10:104640052 G/A cg04362960 chr10:104952993 NT5C2 0.42 10.04 0.37 4.11e-22 Arsenic metabolism; BRCA cis rs6542838 0.611 rs13006398 chr2:99522323 T/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.39 -8.78 -0.33 1.44e-17 Fear of minor pain; BRCA cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg23887609 chr12:130822674 PIWIL1 0.43 9.33 0.35 1.71e-19 Menopause (age at onset); BRCA cis rs372883 0.506 rs2832301 chr21:30749712 G/A cg24692254 chr21:30365293 RNF160 0.38 8.8 0.33 1.27e-17 Pancreatic cancer; BRCA cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg02931644 chr1:25747376 RHCE 0.4 11.31 0.41 3.76e-27 Erythrocyte sedimentation rate; BRCA cis rs2016266 0.859 rs11170507 chr12:53740682 C/A cg26875137 chr12:53738046 NA -0.44 -9.67 -0.36 9.75e-21 Bone mineral density (spine);Bone mineral density; BRCA cis rs1568889 0.838 rs11030187 chr11:28044391 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.78 20.34 0.63 2.76e-71 Bipolar disorder; BRCA trans rs7246760 0.867 rs58461110 chr19:9833390 G/A cg02900749 chr2:68251473 NA -0.48 -7.93 -0.3 1e-14 Pursuit maintenance gain; BRCA cis rs2282802 0.685 rs7730245 chr5:139628163 C/A cg26211634 chr5:139558579 C5orf32 0.35 8.34 0.31 4.45e-16 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs1611753 chr1:152956381 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.44 -0.35 7.05e-20 Inflammatory skin disease; BRCA trans rs2204008 0.713 rs2320522 chr12:38251438 C/T cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Bladder cancer; BRCA cis rs778371 0.697 rs6717048 chr2:233586427 T/C cg08000102 chr2:233561755 GIGYF2 0.85 20.93 0.64 1.86e-74 Schizophrenia; BRCA cis rs6484504 0.553 rs2183484 chr11:31259370 G/A cg14844989 chr11:31128820 NA -0.44 -9.54 -0.35 3.05e-20 Red blood cell count; BRCA cis rs12210905 0.688 rs9368509 chr6:27379422 A/G cg08851530 chr6:28072375 NA -0.8 -7.93 -0.3 9.84e-15 Hip circumference adjusted for BMI; BRCA cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA trans rs911555 0.755 rs6575988 chr14:103900827 G/T cg17675199 chr6:35436792 RPL10A -0.29 -7.81 -0.3 2.31e-14 Intelligence (multi-trait analysis); BRCA cis rs17209837 0.527 rs45479991 chr7:87083339 A/T cg00919237 chr7:87102261 ABCB4 -0.52 -10.01 -0.37 5.04e-22 Gallbladder cancer; BRCA cis rs3733585 0.753 rs12500805 chr4:10017979 C/T cg11266682 chr4:10021025 SLC2A9 0.46 12.33 0.44 1.74e-31 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2204008 0.837 rs12581130 chr12:38319387 A/G cg06521331 chr12:34319734 NA -0.45 -8.58 -0.32 7.16e-17 Bladder cancer; BRCA cis rs13256369 0.901 rs12681298 chr8:8566235 A/G cg00074818 chr8:8560427 CLDN23 -0.35 -8.01 -0.3 5.38e-15 Obesity-related traits; BRCA cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.94 0.3 8.94e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg19717773 chr7:2847554 GNA12 -0.43 -9.75 -0.36 5.03e-21 Height; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg07308232 chr7:1071921 C7orf50 -0.49 -10.24 -0.38 6.68e-23 Longevity;Endometriosis; BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg14004847 chr7:1930337 MAD1L1 -0.41 -7.91 -0.3 1.17e-14 Bipolar disorder and schizophrenia; BRCA cis rs13118159 0.934 rs4974608 chr4:1356780 C/T cg20887711 chr4:1340912 KIAA1530 0.38 8.89 0.33 5.97e-18 Longevity; BRCA cis rs12210905 0.688 rs12199806 chr6:27435943 A/C cg08851530 chr6:28072375 NA 0.81 7.97 0.3 7.05e-15 Hip circumference adjusted for BMI; BRCA cis rs2289583 0.544 rs6495132 chr15:75255322 C/T cg10253484 chr15:75165896 SCAMP2 0.42 8.38 0.31 3.37e-16 Systemic lupus erythematosus; BRCA cis rs12477438 0.684 rs6756880 chr2:99676991 A/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs7666738 0.830 rs7682991 chr4:98982595 C/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs17209837 0.607 rs2270187 chr7:87080698 T/C cg00919237 chr7:87102261 ABCB4 -0.52 -10.15 -0.37 1.5e-22 Gallbladder cancer; BRCA cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg23583168 chr7:148888333 NA -0.85 -19.57 -0.61 3.56e-67 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.28 -0.44 2.82e-31 Chronic sinus infection; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg16145915 chr7:1198662 ZFAND2A -0.63 -15.2 -0.52 9.18e-45 Longevity;Endometriosis; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.34 -0.31 4.61e-16 Total body bone mineral density; BRCA cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg21573476 chr21:45109991 RRP1B 0.34 8.73 0.33 2.19e-17 Mean corpuscular volume; BRCA cis rs17095355 0.901 rs7069128 chr10:111760075 C/T cg00817464 chr10:111662876 XPNPEP1 0.37 9.48 0.35 4.95e-20 Biliary atresia; BRCA cis rs9549367 0.789 rs8001506 chr13:113867153 A/C cg18105134 chr13:113819100 PROZ -0.62 -14.3 -0.49 1.99e-40 Platelet distribution width; BRCA cis rs4819052 0.851 rs4819044 chr21:46660118 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 12.86 0.45 8.26e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2806561 0.704 rs664301 chr1:23522522 C/T cg19743168 chr1:23544995 NA 0.35 8.15 0.31 1.89e-15 Height; BRCA cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg01475377 chr6:109611718 NA -0.56 -15.06 -0.51 4.31e-44 Reticulocyte fraction of red cells; BRCA cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg21770322 chr7:97807741 LMTK2 0.42 11.27 0.41 5.33e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs6690583 0.697 rs4907126 chr1:85523453 C/T cg22153463 chr1:85462885 MCOLN2 0.56 10.17 0.37 1.33e-22 Serum sulfate level; BRCA cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg26516362 chr5:178986906 RUFY1 0.35 8.72 0.33 2.38e-17 Lung cancer; BRCA cis rs12477438 1.000 rs57846982 chr2:99921574 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -14.53 -0.5 1.5e-41 Chronic sinus infection; BRCA cis rs12762955 0.561 rs2620942 chr10:1048398 C/T cg26597838 chr10:835615 NA 0.55 9.97 0.37 7.17e-22 Response to angiotensin II receptor blocker therapy; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg09256448 chr16:638327 NA 0.3 8.01 0.3 5.61e-15 Height; BRCA cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.01 0.4 6.14e-26 Electroencephalogram traits; BRCA cis rs7833986 0.818 rs79824205 chr8:57093233 A/T cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.27 0.31 7.97e-16 Height; BRCA cis rs6088580 0.634 rs6088502 chr20:33037644 A/T cg08999081 chr20:33150536 PIGU 0.45 12.47 0.44 4.3e-32 Glomerular filtration rate (creatinine); BRCA cis rs7072216 0.763 rs7911036 chr10:100167015 A/T cg26618903 chr10:100175079 PYROXD2 -0.31 -8.96 -0.33 3.58e-18 Metabolite levels; BRCA cis rs13046373 0.535 rs9977510 chr21:32027920 A/G cg22337977 chr21:31811175 KRTAP15-1 0.34 7.83 0.3 2.06e-14 HDL cholesterol; BRCA cis rs7809950 0.678 rs982447 chr7:106973534 T/C cg23024343 chr7:107201750 COG5 -0.46 -9.51 -0.35 3.65e-20 Coronary artery disease; BRCA cis rs11098499 0.954 rs10006877 chr4:120242793 C/T cg09307838 chr4:120376055 NA 0.69 14.55 0.5 1.29e-41 Corneal astigmatism; BRCA cis rs17270561 0.609 rs7450798 chr6:25719280 T/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.77 0.33 1.59e-17 Iron status biomarkers; BRCA cis rs7493 0.755 rs17166861 chr7:95020602 G/C cg19678392 chr7:94953810 PON1 -0.41 -8.68 -0.32 3.38e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs919433 1.000 rs6741380 chr2:198165121 A/G cg03934865 chr2:198174659 NA 0.38 8.17 0.31 1.6e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs208520 1.000 rs208520 chr6:66952828 G/T cg07460842 chr6:66804631 NA -0.79 -13.3 -0.47 8.34e-36 Exhaled nitric oxide output; BRCA cis rs7615952 0.641 rs60839048 chr3:125807938 G/A cg06494592 chr3:125709126 NA -0.53 -8.22 -0.31 1.17e-15 Blood pressure (smoking interaction); BRCA cis rs425277 0.606 rs424079 chr1:2071340 C/A cg04315214 chr1:2043799 PRKCZ 0.47 12.82 0.45 1.23e-33 Height; BRCA cis rs35110281 0.811 rs2838337 chr21:45072621 A/C cg04455712 chr21:45112962 RRP1B 0.38 9.8 0.36 3.29e-21 Mean corpuscular volume; BRCA cis rs868036 0.915 rs4489954 chr15:68072075 A/C cg08079166 chr15:68083412 MAP2K5 -0.36 -9.6 -0.36 1.76e-20 Restless legs syndrome; BRCA cis rs10193935 1.000 rs13421289 chr2:42412808 T/C cg27598129 chr2:42591480 NA -0.93 -14.82 -0.51 6.13e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6066825 0.644 rs926629 chr20:47335736 A/G cg18078177 chr20:47281410 PREX1 0.37 9.13 0.34 8.97e-19 Colorectal cancer; BRCA cis rs910316 1.000 rs11623413 chr14:75588824 C/T cg23033748 chr14:75592666 NEK9 -0.41 -9.81 -0.36 3.07e-21 Height; BRCA cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg02221750 chr19:17393354 ANKLE1 -0.65 -12.55 -0.44 1.92e-32 Systemic lupus erythematosus; BRCA cis rs6089829 0.962 rs4586690 chr20:61658595 G/T cg02544614 chr20:61657117 NA 0.28 7.85 0.3 1.8e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs12681287 0.640 rs6471309 chr8:87387760 C/T cg27223183 chr8:87520930 FAM82B -0.43 -8.23 -0.31 1.03e-15 Caudate activity during reward; BRCA trans rs3749237 1.000 rs11717256 chr3:49868520 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.35 9.04 0.34 1.9e-18 Resting heart rate; BRCA cis rs3741404 0.665 rs12418535 chr11:63910980 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 19.73 0.62 4.82e-68 Platelet count; BRCA cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg23649088 chr2:200775458 C2orf69 -0.57 -8.58 -0.32 7.36e-17 Schizophrenia; BRCA trans rs2797160 1.000 rs984040 chr6:126021277 A/G cg05039488 chr6:79577232 IRAK1BP1 0.37 8.44 0.32 2.16e-16 Endometrial cancer; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg11814155 chr7:99998594 ZCWPW1 0.46 8.22 0.31 1.16e-15 Platelet count; BRCA cis rs7552404 0.924 rs67757078 chr1:76169456 G/A cg10523679 chr1:76189770 ACADM 0.88 20.7 0.63 2.98e-73 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.79 12.71 0.45 3.63e-33 Mean platelet volume; BRCA cis rs2991971 0.810 rs2356413 chr1:45914048 A/T cg15605315 chr1:45957053 TESK2 -0.46 -9.26 -0.34 2.97e-19 High light scatter reticulocyte count; BRCA cis rs13161895 1.000 rs13161895 chr5:179471201 C/T cg02702477 chr5:179499311 RNF130 0.46 8.53 0.32 1.03e-16 LDL cholesterol; BRCA cis rs7103648 0.966 rs874896 chr11:47418953 C/G cg20307385 chr11:47447363 PSMC3 0.86 25.86 0.72 1.91e-101 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs13046373 0.562 rs12627602 chr21:32022924 G/A cg06468780 chr21:31798236 KRTAP13-3 0.33 8.37 0.31 3.62e-16 HDL cholesterol; BRCA cis rs6570726 0.935 rs400968 chr6:145819718 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.0 0.51 8.96e-44 Lobe attachment (rater-scored or self-reported); BRCA trans rs3857536 0.706 rs1418854 chr6:66893284 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.48 -0.35 5e-20 Blood trace element (Cu levels); BRCA cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg05535760 chr7:792225 HEATR2 -0.72 -11.64 -0.42 1.59e-28 Cerebrospinal P-tau181p levels; BRCA cis rs6495367 0.898 rs1443657 chr15:79386946 C/A cg17916960 chr15:79447300 NA 0.4 9.41 0.35 8.72e-20 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs56235845 0.694 rs6876677 chr5:176755342 T/C cg06060754 chr5:176797920 RGS14 0.56 10.88 0.4 2.08e-25 Hemoglobin concentration;Hematocrit; BRCA cis rs58785573 0.504 rs13151185 chr4:38609196 G/T cg18361445 chr4:38666374 KLF3;FLJ13197 0.51 9.64 0.36 1.28e-20 Lymphocyte percentage of white cells; BRCA cis rs8017423 0.874 rs4900029 chr14:90686257 T/A cg14092571 chr14:90743983 NA -0.35 -8.16 -0.31 1.72e-15 Mortality in heart failure; BRCA cis rs2204008 0.658 rs11495742 chr12:38395688 C/A cg26384229 chr12:38710491 ALG10B 0.77 17.42 0.57 6.85e-56 Bladder cancer; BRCA cis rs7582180 0.652 rs4851307 chr2:100971778 C/T cg14675211 chr2:100938903 LONRF2 0.51 11.41 0.41 1.39e-27 Intelligence (multi-trait analysis); BRCA cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg06640241 chr16:89574553 SPG7 0.57 12.66 0.45 6.48e-33 Multiple myeloma (IgH translocation); BRCA cis rs13315871 0.929 rs13101057 chr3:58291467 A/G cg20936604 chr3:58311152 NA -0.67 -8.64 -0.32 4.35e-17 Cholesterol, total; BRCA trans rs60843830 0.928 rs55742348 chr2:217563 T/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.45 0.5 3.59e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg24642439 chr20:33292090 TP53INP2 -0.43 -8.7 -0.33 2.89e-17 Height; BRCA trans rs11039571 0.544 rs7947811 chr11:48167738 C/T cg15704280 chr7:45808275 SEPT13 -0.48 -8.05 -0.3 4.12e-15 D-dimer levels; BRCA cis rs651907 0.557 rs2288272 chr3:101378476 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.36 -0.31 3.89e-16 Colorectal cancer; BRCA cis rs698833 0.962 rs698828 chr2:44730577 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.49 0.35 4.43e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9790314 0.740 rs4856767 chr3:161004379 C/T cg03342759 chr3:160939853 NMD3 -0.72 -18.0 -0.58 6.91e-59 Morning vs. evening chronotype; BRCA cis rs2075371 0.611 rs62462979 chr7:134019379 G/T cg20476274 chr7:133979776 SLC35B4 0.53 13.48 0.47 1.22e-36 Mean platelet volume; BRCA cis rs7726839 0.794 rs11739663 chr5:594083 A/G cg09021430 chr5:549028 NA -0.52 -14.07 -0.49 2.38e-39 Obesity-related traits; BRCA cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg13010199 chr12:38710504 ALG10B 0.53 10.79 0.39 4.56e-25 Bladder cancer; BRCA cis rs861020 0.959 rs658860 chr1:209990549 C/T cg09163369 chr1:210001066 C1orf107 0.52 9.71 0.36 6.7e-21 Orofacial clefts; BRCA cis rs7666738 0.830 rs1534319 chr4:98964804 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA cis rs4727027 0.933 rs917123 chr7:148848358 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 8.57 0.32 7.9e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs921968 0.544 rs58827325 chr2:219415166 A/T cg02176678 chr2:219576539 TTLL4 0.46 11.97 0.43 6.09e-30 Mean corpuscular hemoglobin concentration; BRCA trans rs34421088 0.548 rs2618443 chr8:11384556 A/G cg06636001 chr8:8085503 FLJ10661 -0.58 -13.16 -0.46 3.71e-35 Neuroticism; BRCA cis rs7937682 0.883 rs566647 chr11:111466607 A/G cg09085632 chr11:111637200 PPP2R1B 0.81 15.49 0.52 3.63e-46 Primary sclerosing cholangitis; BRCA cis rs11711311 0.911 rs28577577 chr3:113447276 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs7772486 0.686 rs4895684 chr6:146114023 A/C cg13319975 chr6:146136371 FBXO30 0.34 7.97 0.3 7.19e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9300255 0.663 rs7953929 chr12:123758235 C/G cg00376283 chr12:123451042 ABCB9 0.5 10.23 0.38 7.71e-23 Neutrophil percentage of white cells; BRCA cis rs2882667 0.690 rs288039 chr5:138206200 G/T cg04439458 chr5:138467593 SIL1 -0.31 -7.94 -0.3 8.86e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs35110281 0.720 rs162375 chr21:44927015 C/T cg04455712 chr21:45112962 RRP1B -0.43 -10.97 -0.4 8.91e-26 Mean corpuscular volume; BRCA cis rs7586879 0.681 rs6723803 chr2:25120713 G/C cg01884057 chr2:25150051 NA 0.34 9.04 0.34 1.88e-18 Body mass index; BRCA cis rs894734 0.535 rs2366144 chr12:54324069 G/T cg17410650 chr12:54324560 NA -0.48 -13.6 -0.47 3.65e-37 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimetabolite drugs); BRCA cis rs999943 0.846 rs10947420 chr6:33611061 C/G cg14003231 chr6:33640908 ITPR3 0.6 13.86 0.48 2.17e-38 Obesity (extreme); BRCA cis rs208520 0.754 rs851592 chr6:66875175 G/T cg07460842 chr6:66804631 NA -0.98 -18.46 -0.59 2.69e-61 Exhaled nitric oxide output; BRCA cis rs56104184 0.775 rs117744769 chr19:49402686 G/T cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2115630 0.967 rs8028490 chr15:85277888 G/A cg11189052 chr15:85197271 WDR73 -0.38 -9.03 -0.34 1.97e-18 P wave terminal force; BRCA cis rs736408 0.648 rs3774354 chr3:52817675 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 9.38 0.35 1.14e-19 Bipolar disorder; BRCA cis rs7944584 0.632 rs11606683 chr11:47302733 C/T cg03711944 chr11:47377212 SPI1 -0.37 -8.22 -0.31 1.1e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 20.1 0.62 5.33e-70 Smoking behavior; BRCA cis rs1707322 0.758 rs10789474 chr1:46250040 G/T cg03146154 chr1:46216737 IPP 0.53 11.78 0.42 3.81e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8005677 1.000 rs8006409 chr14:23396511 A/G cg01529538 chr14:23388837 RBM23 0.42 11.45 0.41 9.89e-28 Cognitive ability (multi-trait analysis); BRCA cis rs7246657 0.722 rs28512414 chr19:38056574 T/A cg18154014 chr19:37997991 ZNF793 0.48 9.13 0.34 8.69e-19 Coronary artery calcification; BRCA cis rs1707322 0.717 rs28396194 chr1:46213227 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9462846 0.960 rs12194860 chr6:42862934 C/T cg02353165 chr6:42928485 GNMT 0.43 8.06 0.3 3.67e-15 Blood protein levels; BRCA cis rs11971779 0.941 rs6954453 chr7:139031794 C/T cg07862535 chr7:139043722 LUC7L2 0.53 12.93 0.46 3.82e-34 Diisocyanate-induced asthma; BRCA cis rs4076764 0.914 rs10753614 chr1:163365903 C/T cg06092702 chr1:163392909 NA 0.35 9.77 0.36 4.3e-21 Motion sickness; BRCA cis rs2336384 1.000 rs61776516 chr1:12047028 T/C cg13216073 chr1:12042593 MFN2 0.44 9.59 0.35 1.93e-20 Platelet count; BRCA cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg12432903 chr7:1882776 MAD1L1 0.45 8.1 0.31 2.88e-15 Bipolar disorder; BRCA cis rs11030122 0.632 rs714380 chr11:4059653 A/T cg18678763 chr11:4115507 RRM1 -0.35 -8.25 -0.31 8.95e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs265548 0.646 rs36692 chr19:17906839 C/T cg16024904 chr19:17905718 B3GNT3 0.38 8.05 0.3 4.02e-15 Tumor biomarkers; BRCA cis rs72772090 0.710 rs1559085 chr5:96078702 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.76 -0.45 2.16e-33 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2336384 1.000 rs2336384 chr1:12046063 A/C cg13216073 chr1:12042593 MFN2 -0.45 -9.81 -0.36 3.08e-21 Platelet count; BRCA cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.82 -0.33 1.08e-17 Developmental language disorder (linguistic errors); BRCA cis rs4268898 0.662 rs2303296 chr2:24432839 A/G cg06627628 chr2:24431161 ITSN2 -0.85 -15.66 -0.53 5.08e-47 Asthma; BRCA cis rs4845875 0.534 rs6541003 chr1:11855867 G/A cg24844545 chr1:11908347 NPPA 0.31 7.86 0.3 1.58e-14 Midregional pro atrial natriuretic peptide levels; BRCA cis rs6430585 0.528 rs6430594 chr2:136719173 C/T cg07169764 chr2:136633963 MCM6 -1.25 -26.32 -0.72 5.82e-104 Corneal structure; BRCA cis rs6952808 0.931 rs12537479 chr7:1868995 A/G cg13880726 chr7:1868755 MAD1L1 -0.55 -11.3 -0.41 3.87e-27 Bipolar disorder and schizophrenia; BRCA cis rs6060717 0.536 rs6060704 chr20:34530270 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.04 -0.3 4.27e-15 Hip circumference adjusted for BMI; BRCA cis rs11229555 0.645 rs17474373 chr11:58191243 G/A cg15696309 chr11:58395628 NA -0.52 -10.83 -0.39 3.19e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7592578 0.664 rs10931461 chr2:191405280 T/A cg10560079 chr2:191398806 TMEM194B 0.73 13.36 0.47 4.5e-36 Diastolic blood pressure; BRCA cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -7.9 -0.3 1.2e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs4911152 chr20:32955024 T/C cg08999081 chr20:33150536 PIGU -0.45 -12.4 -0.44 8.63e-32 Glomerular filtration rate (creatinine); BRCA cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg11057378 chr10:81107060 PPIF 0.4 9.28 0.34 2.65e-19 Height; BRCA cis rs765787 0.556 rs10851422 chr15:45513738 T/C cg15395560 chr15:45543142 SLC28A2 -0.3 -8.15 -0.31 1.93e-15 Uric acid levels; BRCA cis rs7264396 0.790 rs6058294 chr20:34259396 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.39 8.25 0.31 9.01e-16 Total cholesterol levels; BRCA cis rs2075371 0.966 rs1619682 chr7:133996703 T/G cg20476274 chr7:133979776 SLC35B4 0.66 19.45 0.61 1.48e-66 Mean platelet volume; BRCA cis rs9811920 0.683 rs1718235 chr3:99583484 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.45 -10.77 -0.39 5.71e-25 Axial length; BRCA cis rs10857712 0.754 rs2297031 chr10:135232654 C/T cg17796960 chr10:135278976 LOC619207 -0.43 -9.03 -0.34 2.03e-18 Systemic lupus erythematosus; BRCA cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg11366901 chr6:160182831 ACAT2 0.84 16.6 0.55 1.02e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -11.44 -0.41 1.07e-27 Monocyte count; BRCA cis rs908922 0.676 rs10888492 chr1:152499908 G/C cg20991723 chr1:152506922 NA 0.41 9.47 0.35 5.21e-20 Hair morphology; BRCA cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA trans rs11039798 0.610 rs11530356 chr11:48836290 C/A cg15704280 chr7:45808275 SEPT13 0.6 8.92 0.33 4.77e-18 Axial length; BRCA trans rs911555 0.723 rs2273701 chr14:103923225 G/T cg17675199 chr6:35436792 RPL10A -0.3 -8.05 -0.3 3.9e-15 Intelligence (multi-trait analysis); BRCA cis rs1949733 1.000 rs3103071 chr4:8508579 C/G cg11789530 chr4:8429930 ACOX3 -0.7 -17.99 -0.58 7.96e-59 Response to antineoplastic agents; BRCA cis rs2153535 0.580 rs6421949 chr6:8531769 G/A cg21535247 chr6:8435926 SLC35B3 0.41 9.27 0.34 2.9e-19 Motion sickness; BRCA cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg26384229 chr12:38710491 ALG10B 0.74 17.29 0.56 3.29e-55 Bladder cancer; BRCA cis rs6570726 0.935 rs414222 chr6:145850482 C/T cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs2180341 0.814 rs9385424 chr6:127726796 A/G cg24812749 chr6:127587940 RNF146 0.68 15.41 0.52 8.21e-46 Breast cancer; BRCA cis rs5750830 0.649 rs5750811 chr22:39793066 G/T cg05872129 chr22:39784769 NA 0.56 11.83 0.42 2.41e-29 Intelligence (multi-trait analysis); BRCA cis rs6840360 0.615 rs6831810 chr4:152461995 A/G cg22705602 chr4:152727874 NA -0.33 -8.02 -0.3 5.22e-15 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg22903471 chr2:27725779 GCKR -0.35 -8.61 -0.32 5.83e-17 Total body bone mineral density; BRCA cis rs10504229 0.683 rs1495866 chr8:58141128 T/C cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs56344958 chr1:46814518 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.24 0.31 1.01e-15 Menopause (age at onset); BRCA cis rs6430585 0.528 rs309161 chr2:136688749 A/G cg07169764 chr2:136633963 MCM6 -0.9 -17.2 -0.56 8.61e-55 Corneal structure; BRCA cis rs10197940 0.545 rs2444267 chr2:152308611 T/G cg06191203 chr2:152266755 RIF1 -0.27 -8.16 -0.31 1.83e-15 Lung cancer; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.06 -18.86 -0.6 1.99e-63 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs96067 0.772 rs1033891 chr1:36608402 A/G cg24686825 chr1:36642396 MAP7D1 -0.46 -8.45 -0.32 2.04e-16 Corneal structure; BRCA cis rs2386661 0.547 rs11259540 chr10:5646706 A/T cg17085576 chr10:5658249 NA -0.33 -8.21 -0.31 1.23e-15 Breast cancer; BRCA cis rs826838 0.935 rs1719855 chr12:39127242 C/T cg26384229 chr12:38710491 ALG10B -0.62 -16.21 -0.54 8.87e-50 Heart rate; BRCA cis rs8062405 0.755 rs7193402 chr16:28586127 A/G cg16576597 chr16:28551801 NUPR1 0.33 9.11 0.34 1.07e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4910157 1 rs4910157 chr11:8941215 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.56 12.54 0.44 2.06e-32 Tonsillectomy; BRCA trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -13.86 -0.48 2.11e-38 Extrinsic epigenetic age acceleration; BRCA trans rs2797160 0.967 rs2797159 chr6:126009557 G/A cg05039488 chr6:79577232 IRAK1BP1 0.36 8.07 0.3 3.49e-15 Endometrial cancer; BRCA trans rs1973993 0.967 rs10489741 chr1:96942406 G/A cg10631902 chr5:14652156 NA 0.52 16.53 0.55 2.19e-51 Weight; BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg03188948 chr7:1209495 NA 0.68 11.2 0.41 1.06e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4975616 0.869 rs467095 chr5:1336221 T/C cg07493874 chr5:1342172 CLPTM1L -0.54 -15.47 -0.52 4.39e-46 Lung cancer; BRCA trans rs4689592 0.554 rs3822270 chr4:7069804 C/A cg07817883 chr1:32538562 TMEM39B -0.44 -8.49 -0.32 1.44e-16 Monocyte percentage of white cells; BRCA cis rs7831492 0.564 rs7831530 chr8:41614567 G/A cg17182837 chr8:41585554 ANK1 -0.31 -8.25 -0.31 9.39e-16 Colorectal cancer; BRCA trans rs61931739 0.500 rs11615231 chr12:34413330 T/C cg13010199 chr12:38710504 ALG10B 0.48 9.5 0.35 4.19e-20 Morning vs. evening chronotype; BRCA cis rs7917772 0.503 rs7896841 chr10:104294665 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.830 rs28810677 chr4:99043193 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6089584 0.821 rs2273990 chr20:60579149 G/T cg13770153 chr20:60521292 NA -0.45 -10.88 -0.4 2.1e-25 Body mass index; BRCA cis rs1371614 0.545 rs4665930 chr2:27173520 C/T cg00617064 chr2:27272375 NA 0.31 8.07 0.3 3.62e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -8.46 -0.32 1.85e-16 Personality dimensions; BRCA trans rs60843830 1.000 rs60149603 chr2:285421 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.75 0.5 1.35e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg06618935 chr21:46677482 NA -0.37 -8.37 -0.31 3.67e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs11098499 0.526 rs10026625 chr4:120280136 T/C cg25214090 chr10:38739885 LOC399744 0.38 8.9 0.33 5.88e-18 Corneal astigmatism; BRCA cis rs4689592 0.503 rs11937667 chr4:7057037 C/G cg06697600 chr4:7070879 GRPEL1 0.6 10.28 0.38 4.72e-23 Monocyte percentage of white cells; BRCA cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg22974920 chr21:40686053 BRWD1 -0.39 -8.6 -0.32 5.97e-17 Cognitive function; BRCA trans rs9329221 0.686 rs60755617 chr8:10243327 T/G cg06636001 chr8:8085503 FLJ10661 0.53 10.05 0.37 3.68e-22 Neuroticism; BRCA trans rs4714291 0.802 rs7759622 chr6:40114735 C/T cg02267698 chr19:7991119 CTXN1 -0.46 -9.56 -0.35 2.49e-20 Strep throat; BRCA cis rs9875589 0.509 rs7614591 chr3:14061118 A/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.95 0.33 3.85e-18 Ovarian reserve; BRCA cis rs17376456 0.877 rs10044066 chr5:93437580 T/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.6 8.24 0.31 9.45e-16 Diabetic retinopathy; BRCA cis rs17376456 1.000 rs34756085 chr5:93556294 A/G cg21475434 chr5:93447410 FAM172A 0.72 9.06 0.34 1.54e-18 Diabetic retinopathy; BRCA cis rs4363385 0.720 rs6665527 chr1:152967009 C/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.26 -0.34 3.1400000000000002e-19 Inflammatory skin disease; BRCA cis rs198389 0.589 rs535107 chr1:11889468 C/T cg06193043 chr1:11908199 NPPA 0.32 8.21 0.31 1.27e-15 B-type natriuretic peptide levels;NT-proBNP levels in acute coronary syndrome; BRCA cis rs3741404 0.620 rs2236648 chr11:63964657 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.6 13.87 0.48 1.97e-38 Platelet count; BRCA cis rs427394 0.632 rs2279656 chr5:6737576 G/A cg10857441 chr5:6722123 POLS -0.32 -10.09 -0.37 2.64e-22 Menopause (age at onset); BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs61931739 0.500 rs10844863 chr12:34532284 C/T cg06521331 chr12:34319734 NA -0.53 -10.29 -0.38 4.23e-23 Morning vs. evening chronotype; BRCA cis rs9640161 0.789 rs34311995 chr7:150059255 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.54 -12.61 -0.45 1.06e-32 Blood protein levels;Circulating chemerin levels; BRCA trans rs11098499 0.569 rs55845118 chr4:120290913 T/C cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs7520050 0.966 rs785492 chr1:46583607 G/A cg24296786 chr1:45957014 TESK2 0.43 9.69 0.36 8.26e-21 Red blood cell count;Reticulocyte count; BRCA cis rs1801251 0.963 rs7591176 chr2:233581803 C/A cg25237894 chr2:233734115 C2orf82 0.4 11.43 0.41 1.15e-27 Coronary artery disease; BRCA trans rs61931739 0.500 rs1601628 chr12:34047375 A/C cg13010199 chr12:38710504 ALG10B 0.4 8.16 0.31 1.74e-15 Morning vs. evening chronotype; BRCA cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24549020 chr5:56110836 MAP3K1 -0.4 -8.33 -0.31 4.98e-16 Initial pursuit acceleration; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.88 16.19 0.54 1.13e-49 Platelet count; BRCA cis rs919433 1.000 rs919433 chr2:198166565 G/A cg10820045 chr2:198174542 NA -0.39 -8.44 -0.32 2.12e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg23625390 chr15:77176239 SCAPER -0.38 -9.16 -0.34 6.83e-19 Blood metabolite levels; BRCA trans rs7395662 0.591 rs11039858 chr11:48611651 C/T cg15704280 chr7:45808275 SEPT13 -0.49 -9.54 -0.35 3.02e-20 HDL cholesterol; BRCA cis rs2197308 0.765 rs11182900 chr12:37934009 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5e-22 Morning vs. evening chronotype; BRCA cis rs7666738 0.791 rs34437628 chr4:99029232 C/G cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.583 rs578451 chr18:44404525 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.91 -0.4 1.57e-25 Personality dimensions; BRCA trans rs7726839 0.561 rs4957048 chr5:583442 G/A cg25482853 chr8:67687455 SGK3 0.79 13.2 0.46 2.48e-35 Obesity-related traits; BRCA cis rs72848980 0.512 rs56984020 chr10:105386275 C/A cg00126946 chr10:105363258 SH3PXD2A 0.44 8.49 0.32 1.42e-16 White matter hyperintensity burden; BRCA cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg08807101 chr21:30365312 RNF160 -0.59 -14.68 -0.5 3.11e-42 Dental caries; BRCA cis rs6930083 0.737 rs13196885 chr6:36632688 C/T cg08179530 chr6:36648295 CDKN1A -0.62 -14.38 -0.49 8.08e-41 Coronary artery disease; BRCA cis rs6831352 0.760 rs2602859 chr4:100030583 G/A cg12011299 chr4:100065546 ADH4 0.48 10.82 0.39 3.58e-25 Alcohol dependence; BRCA cis rs7512552 0.839 rs11590787 chr1:150398531 G/A cg15654264 chr1:150340011 RPRD2 0.37 8.16 0.31 1.76e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs514406 0.505 rs6703127 chr1:53180565 C/T cg16325326 chr1:53192061 ZYG11B 0.91 24.96 0.7 1.71e-96 Monocyte count; BRCA cis rs2251381 0.750 rs8129616 chr21:30520085 C/T cg08807101 chr21:30365312 RNF160 -0.6 -13.06 -0.46 9.83e-35 Selective IgA deficiency; BRCA cis rs2015599 0.549 rs9738165 chr12:29443196 T/C cg09582351 chr12:29534625 ERGIC2 -0.34 -7.98 -0.3 6.94e-15 Mean platelet volume;Platelet count; BRCA cis rs2415984 0.622 rs7156466 chr14:46933384 A/G cg14871534 chr14:47121158 RPL10L -0.37 -8.82 -0.33 1.12e-17 Number of children ever born; BRCA cis rs1048238 0.846 rs945420 chr1:16345208 G/A cg06159980 chr1:16340746 HSPB7 -0.39 -8.82 -0.33 1.11e-17 Systolic blood pressure; BRCA cis rs11718455 0.960 rs17076254 chr3:44000361 C/T cg08738300 chr3:44038990 NA 0.42 8.19 0.31 1.44e-15 Coronary artery disease; BRCA cis rs5167 0.504 rs73047641 chr19:45457377 G/A cg09555818 chr19:45449301 APOC2 0.46 11.91 0.43 1.08e-29 Blood protein levels; BRCA cis rs9291683 0.632 rs12508991 chr4:10041104 C/T cg00071950 chr4:10020882 SLC2A9 0.64 15.73 0.53 2.16e-47 Bone mineral density; BRCA cis rs2991971 0.903 rs2991973 chr1:46020632 G/A cg24296786 chr1:45957014 TESK2 0.63 15.54 0.52 2.04e-46 High light scatter reticulocyte count; BRCA cis rs1577917 0.958 rs2324817 chr6:86462654 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.28 -0.44 2.76e-31 Response to antipsychotic treatment; BRCA cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 17.85 0.58 4.24e-58 Age-related macular degeneration (geographic atrophy); BRCA cis rs875971 0.862 rs6460282 chr7:65691246 T/C cg11764359 chr7:65958608 NA -0.74 -16.13 -0.54 2.3e-49 Aortic root size; BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg00106254 chr7:1943704 MAD1L1 -0.33 -8.16 -0.31 1.8e-15 Schizophrenia; BRCA cis rs13053817 1.000 rs7290684 chr22:29857664 C/T cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.48 -9.25 -0.34 3.35e-19 Carotid atherosclerosis in HIV infection; BRCA cis rs7715806 0.500 rs72633985 chr5:75006384 A/G cg19683494 chr5:74908142 NA 0.5 8.1 0.31 2.81e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12579753 1.000 rs11115017 chr12:82176914 C/A cg07988820 chr12:82153109 PPFIA2 -0.58 -9.34 -0.35 1.53e-19 Resting heart rate; BRCA trans rs1493916 0.837 rs11876492 chr18:31413804 T/C cg15819921 chr19:927150 ARID3A -0.42 -8.35 -0.31 4.15e-16 Life satisfaction; BRCA cis rs1865760 0.865 rs9467641 chr6:25947236 T/C cg17691542 chr6:26056736 HIST1H1C 0.47 9.45 0.35 6.44e-20 Height; BRCA cis rs875971 0.628 rs6974355 chr7:65841981 A/G cg18876405 chr7:65276391 NA 0.65 15.96 0.53 1.66e-48 Aortic root size; BRCA cis rs79839061 0.610 rs17781499 chr4:889384 C/A cg14530993 chr4:882597 GAK 0.59 9.84 0.36 2.27e-21 Intelligence (multi-trait analysis); BRCA trans rs11722228 1.000 rs6823877 chr4:9921931 T/C cg26043149 chr18:55253948 FECH -0.6 -13.28 -0.47 1.08e-35 Gout;Urate levels;Serum uric acid levels; BRCA cis rs7607369 0.559 rs4674341 chr2:219659911 A/G cg02176678 chr2:219576539 TTLL4 -0.39 -10.33 -0.38 3.04e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7760949 0.889 rs9475787 chr6:13926102 G/C cg27413430 chr6:13925136 RNF182 0.46 9.29 0.34 2.43e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs9290065 0.519 rs1447608 chr3:160682019 G/T cg03342759 chr3:160939853 NMD3 -0.46 -9.34 -0.35 1.54e-19 Kawasaki disease; BRCA cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg04455712 chr21:45112962 RRP1B 0.39 10.38 0.38 1.97e-23 Mean corpuscular volume; BRCA cis rs61931739 0.534 rs1912773 chr12:34097401 T/C cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.44e-26 Morning vs. evening chronotype; BRCA cis rs929596 0.561 rs11891311 chr2:234639310 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.43 11.25 0.41 6.41e-27 Total bilirubin levels in HIV-1 infection; BRCA cis rs1965732 0.504 rs13004799 chr2:3716456 G/A cg19052272 chr2:3704530 ALLC -0.33 -8.09 -0.3 3.12e-15 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs7829975 0.582 rs448231 chr8:8790059 A/T cg08975724 chr8:8085496 FLJ10661 -0.42 -9.28 -0.34 2.69e-19 Mood instability; BRCA cis rs965469 1.000 rs6051762 chr20:3321590 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -9.83 -0.36 2.45e-21 IFN-related cytopenia; BRCA cis rs6964587 0.839 rs62466159 chr7:91450507 A/G cg17063962 chr7:91808500 NA 0.51 11.43 0.41 1.13e-27 Breast cancer; BRCA cis rs2070488 1.000 rs4147025 chr3:38456531 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.41 0.61 2.41e-66 Electrocardiographic conduction measures; BRCA cis rs62380364 0.542 rs601499 chr5:88052687 A/C cg22951263 chr5:87985283 NA -0.38 -10.68 -0.39 1.3e-24 Intelligence (multi-trait analysis); BRCA cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg16049864 chr8:95962084 TP53INP1 -0.44 -10.78 -0.39 5.31e-25 Type 2 diabetes; BRCA cis rs6582630 0.519 rs11495376 chr12:38284957 A/C cg26384229 chr12:38710491 ALG10B 0.72 17.04 0.56 6.04e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs1420338 0.967 rs10224203 chr7:34149593 C/T cg01275685 chr7:34179230 BMPER -0.45 -9.7 -0.36 7.76e-21 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs7833790 0.700 rs7834483 chr8:82704828 A/G cg17211192 chr8:82754475 SNX16 -0.54 -11.48 -0.41 7.52e-28 Diastolic blood pressure; BRCA cis rs2625529 0.938 rs2625530 chr15:72126034 G/A cg16672083 chr15:72433130 SENP8 -0.82 -16.87 -0.56 4.51e-53 Red blood cell count; BRCA cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg18761221 chr20:60518478 NA -0.34 -8.36 -0.31 3.97e-16 Obesity-related traits; BRCA cis rs9733 0.596 rs11807058 chr1:150640475 G/A cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg09177884 chr7:1199841 ZFAND2A -0.53 -11.5 -0.41 6.25e-28 Longevity;Endometriosis; BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 17.82 0.58 5.88e-58 Platelet count; BRCA cis rs7666738 0.677 rs13120306 chr4:99036099 A/T cg17366294 chr4:99064904 C4orf37 0.47 10.97 0.4 8.76e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs11190604 0.767 rs10736150 chr10:102195341 G/A cg07080220 chr10:102295463 HIF1AN -0.45 -10.1 -0.37 2.29e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6540559 0.673 rs7511996 chr1:210018473 C/A cg22029157 chr1:209979665 IRF6 0.41 8.0 0.3 5.98e-15 Cleft lip with or without cleft palate; BRCA trans rs208520 0.954 rs12190073 chr6:66983740 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.49 0.5 2.5e-41 Exhaled nitric oxide output; BRCA cis rs7202877 0.610 rs4536500 chr16:75343197 C/G cg03315344 chr16:75512273 CHST6 -0.53 -8.54 -0.32 1.02e-16 Type 2 diabetes;Type 1 diabetes; BRCA cis rs17092148 1.000 rs6060017 chr20:33313042 G/T cg16810054 chr20:33298113 TP53INP2 -0.49 -11.13 -0.4 2.07e-26 Neuroticism; BRCA cis rs4730250 0.707 rs257381 chr7:106803963 T/C cg02696742 chr7:106810147 HBP1 -0.57 -9.54 -0.35 2.98e-20 Osteoarthritis; BRCA trans rs60843830 0.661 rs62116681 chr2:104197 A/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.48 9.38 0.35 1.16e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg22467129 chr15:76604101 ETFA -0.49 -10.76 -0.39 6.38e-25 Blood metabolite levels; BRCA cis rs11779988 0.545 rs439374 chr8:17786818 C/T cg01800426 chr8:17659068 MTUS1 -0.38 -7.9 -0.3 1.26e-14 Breast cancer; BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.77 0.33 1.57e-17 Platelet count; BRCA cis rs10883723 0.810 rs3781289 chr10:104244991 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.72 0.62 5.47e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.15 0.34 7.49e-19 Tonsillectomy; BRCA cis rs2832191 0.967 rs2251377 chr21:30530599 T/C cg08807101 chr21:30365312 RNF160 0.55 13.23 0.46 1.81e-35 Dental caries; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg10862848 chr6:42927986 GNMT -0.36 -15.02 -0.51 6.58e-44 Plasma homocysteine levels (post-methionine load test); BRCA cis rs4908768 0.539 rs4480384 chr1:8659714 A/G cg20416874 chr1:8611966 RERE -0.28 -7.87 -0.3 1.57e-14 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs853679 0.517 rs9368555 chr6:28108967 T/C cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.18 -0.31 1.49e-15 Depression; BRCA cis rs35306767 0.714 rs12767171 chr10:1084491 A/G cg26597838 chr10:835615 NA 0.61 10.56 0.39 3.97e-24 Eosinophil percentage of granulocytes; BRCA cis rs757081 0.671 rs214091 chr11:17296463 A/C cg15432903 chr11:17409602 KCNJ11 -0.47 -8.1 -0.31 2.78e-15 Systolic blood pressure; BRCA cis rs7726839 0.561 rs4957049 chr5:579080 C/A cg09021430 chr5:549028 NA -0.64 -15.17 -0.51 1.26e-44 Obesity-related traits; BRCA cis rs1552244 0.572 rs6797536 chr3:10168802 C/T cg16606324 chr3:10149918 C3orf24 -0.56 -9.96 -0.37 8.39e-22 Alzheimer's disease; BRCA trans rs11098499 0.779 rs7674500 chr4:120303593 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg08888203 chr3:10149979 C3orf24 0.66 13.86 0.48 2.18e-38 Alzheimer's disease; BRCA cis rs2688482 0.557 rs2550236 chr3:195522321 A/G cg18713687 chr3:195489789 MUC4 0.52 8.48 0.32 1.54e-16 Lung disease severity in cystic fibrosis; BRCA trans rs12517041 1.000 rs10520890 chr5:23290143 C/T ch.8.1293020R chr8:59333349 UBXN2B 0.46 8.34 0.31 4.52e-16 Calcium levels; BRCA cis rs11229555 0.598 rs12289876 chr11:58185250 C/T cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11890956 chr21:40555474 PSMG1 1.04 29.41 0.76 7.29e-121 Cognitive function; BRCA cis rs10754283 0.967 rs6428559 chr1:90099036 C/T cg21401794 chr1:90099060 LRRC8C 0.52 12.61 0.45 1.03e-32 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9309473 0.607 rs12478346 chr2:73584360 C/T cg20560298 chr2:73613845 ALMS1 -0.41 -10.93 -0.4 1.33e-25 Metabolite levels; BRCA trans rs11098499 0.954 rs10006877 chr4:120242793 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.46 0.32 1.79e-16 Corneal astigmatism; BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.83 -12.42 -0.44 6.83e-32 Platelet count; BRCA cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg17366294 chr4:99064904 C4orf37 0.41 9.62 0.36 1.47e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs7927771 0.542 rs7102205 chr11:47745374 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.6 0.35 1.84e-20 Subjective well-being; BRCA cis rs7914558 0.966 rs10883805 chr10:104708251 T/C cg04362960 chr10:104952993 NT5C2 0.43 10.54 0.38 4.65e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs7819412 0.740 rs11250119 chr8:11037034 C/T cg15556689 chr8:8085844 FLJ10661 -0.37 -9.48 -0.35 4.98e-20 Triglycerides; BRCA cis rs559928 0.606 rs1011219 chr11:63973396 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.69 -9.92 -0.37 1.19e-21 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs2477686 0.526 rs1998759 chr1:2397174 C/T cg07700843 chr1:2391317 NA -0.45 -9.43 -0.35 7.74e-20 Non-obstructive azoospermia; BRCA cis rs7103648 0.630 rs7934481 chr11:47883337 C/T cg03711944 chr11:47377212 SPI1 -0.39 -9.23 -0.34 3.8e-19 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6834538 0.894 rs34712587 chr4:113485894 A/T cg05166686 chr4:113558556 LARP7;C4orf21 0.38 8.41 0.32 2.59e-16 Free thyroxine concentration; BRCA cis rs7395581 0.877 rs10838691 chr11:47341729 T/C cg25783544 chr11:47291846 MADD 0.4 8.96 0.33 3.47e-18 HDL cholesterol; BRCA cis rs61931739 0.500 rs11053280 chr12:34559297 G/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA cis rs703842 1.000 rs11172342 chr12:58187758 G/T cg00677455 chr12:58241039 CTDSP2 0.63 14.19 0.49 6.18e-40 Multiple sclerosis; BRCA cis rs796364 0.616 rs2689765 chr2:200696352 T/C cg23649088 chr2:200775458 C2orf69 0.54 7.93 0.3 9.5e-15 Schizophrenia; BRCA cis rs12618769 0.597 rs72819986 chr2:99045867 G/C cg10123293 chr2:99228465 UNC50 0.41 8.14 0.31 2.05e-15 Bipolar disorder; BRCA cis rs1008375 0.898 rs2079892 chr4:17577163 G/A cg16339924 chr4:17578868 LAP3 0.67 16.99 0.56 1.05e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6138458 1.000 rs227616 chr20:24908811 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.38 -0.31 3.34e-16 Blood protein levels; BRCA cis rs1499614 0.803 rs1922723 chr7:66175063 C/T cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.6 11.95 0.43 7.88e-30 Tonsillectomy; BRCA cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg00409905 chr10:38381863 ZNF37A -0.57 -12.42 -0.44 6.72e-32 Extrinsic epigenetic age acceleration; BRCA cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg05283184 chr6:79620031 NA -0.39 -9.89 -0.36 1.43e-21 Intelligence (multi-trait analysis); BRCA cis rs7818345 0.935 rs6983973 chr8:19287867 T/C cg11303988 chr8:19266685 CSGALNACT1 0.31 8.02 0.3 5.16e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs35110281 0.713 rs6518310 chr21:45098670 T/A cg04455712 chr21:45112962 RRP1B 0.43 11.69 0.42 9.25e-29 Mean corpuscular volume; BRCA cis rs6460942 0.915 rs6945067 chr7:12444731 A/C cg06484146 chr7:12443880 VWDE -0.71 -10.73 -0.39 8.16e-25 Coronary artery disease; BRCA trans rs2840044 1.000 rs7212704 chr17:33898897 C/T cg19694781 chr19:47549865 TMEM160 0.46 10.92 0.4 1.37e-25 Response to radiotherapy in cancer (late toxicity); BRCA cis rs2749592 0.588 rs2505192 chr10:38395023 G/A cg25427524 chr10:38739819 LOC399744 -0.67 -13.65 -0.48 2.01e-37 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9733 0.596 rs72702504 chr1:150635374 G/C cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg27170947 chr2:26402098 FAM59B -0.92 -16.84 -0.55 6.2e-53 Gut microbiome composition (summer); BRCA cis rs172166 0.694 rs203884 chr6:28077374 G/T cg10876282 chr6:28092338 ZSCAN16 0.4 7.87 0.3 1.48e-14 Cardiac Troponin-T levels; BRCA cis rs17270561 0.583 rs7749149 chr6:25781139 G/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.47 0.35 5.27e-20 Iron status biomarkers; BRCA cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.555 rs11182429 chr12:38526679 A/C cg13010199 chr12:38710504 ALG10B 0.45 9.64 0.36 1.25e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg08470875 chr2:26401718 FAM59B 0.76 11.99 0.43 4.93e-30 Gut microbiome composition (summer); BRCA cis rs9814567 0.865 rs9834981 chr3:134282279 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.95 -0.62 3.47e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2832191 0.720 rs2832200 chr21:30499165 G/A cg08807101 chr21:30365312 RNF160 -0.59 -14.68 -0.5 3.1e-42 Dental caries; BRCA cis rs801193 1.000 rs13239306 chr7:66136017 T/G cg18876405 chr7:65276391 NA -0.61 -14.59 -0.5 7.69e-42 Aortic root size; BRCA cis rs208520 0.874 rs208485 chr6:66925654 T/C cg07460842 chr6:66804631 NA -0.9 -15.67 -0.53 4.71e-47 Exhaled nitric oxide output; BRCA cis rs2180341 0.889 rs2000909 chr6:127711173 G/A cg27446573 chr6:127587934 RNF146 0.7 15.79 0.53 1.21e-47 Breast cancer; BRCA cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.83 0.33 9.66e-18 Motion sickness; BRCA cis rs7666738 0.830 rs11097606 chr4:99011486 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.67 0.39 1.38e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs10516426 chr4:99035827 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9372253 1.000 rs9384740 chr6:110716207 G/A cg00083206 chr6:110721305 DDO -0.4 -9.77 -0.36 4.07e-21 Platelet distribution width; BRCA cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.68 0.36 9.18e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.862 rs801204 chr7:66022921 T/C cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA trans rs2235573 0.551 rs139895 chr22:38397034 A/G cg19894588 chr14:64061835 NA -0.38 -9.13 -0.34 9.17e-19 Glioblastoma;Glioma; BRCA trans rs1422110 0.647 rs10063838 chr5:85530546 T/C cg01787110 chr1:109008453 NBPF6 -0.51 -10.29 -0.38 4.49e-23 Attention function in attention deficit hyperactive disorder; BRCA cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg14926445 chr8:58193284 C8orf71 -0.46 -8.83 -0.33 1.01e-17 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.929 rs2252662 chr2:61670731 T/C cg15711740 chr2:61764176 XPO1 -0.52 -13.18 -0.46 2.96e-35 Tuberculosis; BRCA cis rs8180040 0.593 rs12715421 chr3:47084859 A/G cg16586182 chr3:47516702 SCAP -0.55 -12.31 -0.44 2.1e-31 Colorectal cancer; BRCA cis rs4363385 0.747 rs11205151 chr1:152961496 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.81 -0.33 1.18e-17 Inflammatory skin disease; BRCA cis rs875971 0.830 rs7799834 chr7:65880694 A/C cg11764359 chr7:65958608 NA 0.8 19.49 0.61 9.4e-67 Aortic root size; BRCA cis rs11955398 0.716 rs1379115 chr5:59997886 A/C cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.42e-19 Intelligence (multi-trait analysis); BRCA cis rs3824867 0.920 rs7107853 chr11:47453518 T/C cg20307385 chr11:47447363 PSMC3 -0.51 -11.48 -0.41 6.99e-28 Mean corpuscular hemoglobin; BRCA cis rs4237845 0.715 rs4760340 chr12:58275176 A/T cg02175503 chr12:58329896 NA 0.52 11.74 0.42 5.81e-29 Intelligence (multi-trait analysis); BRCA cis rs61990749 0.597 rs759808 chr14:78250845 T/G cg02301378 chr14:78227641 SNW1;C14orf178 0.58 9.3 0.35 2.19e-19 Fibroblast growth factor basic levels; BRCA cis rs9733 0.596 rs34140753 chr1:150642583 T/C cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs758324 0.947 rs11948962 chr5:131113830 C/T cg06307176 chr5:131281290 NA 0.53 10.2 0.37 9.47e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs11098499 0.954 rs12507964 chr4:120413061 T/A cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.91e-45 Corneal astigmatism; BRCA cis rs2985684 0.948 rs6572592 chr14:50080871 G/A cg04989706 chr14:50066350 PPIL5 -0.47 -8.74 -0.33 2.03e-17 Carotid intima media thickness; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg18765753 chr7:1198926 ZFAND2A -0.48 -11.12 -0.4 2.2e-26 Longevity;Endometriosis; BRCA cis rs483180 0.859 rs478093 chr1:120255126 C/T cg19096424 chr1:120255104 PHGDH -0.6 -13.72 -0.48 1.01e-37 Macular telangiectasia type 2; BRCA cis rs3772130 0.962 rs9841595 chr3:121483326 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.75 0.39 7.12e-25 Cognitive performance; BRCA cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg17724175 chr1:150552817 MCL1 0.26 8.53 0.32 1.03e-16 Tonsillectomy; BRCA cis rs9359856 0.510 rs2768936 chr6:90441851 A/G cg13799429 chr6:90582589 CASP8AP2 -0.7 -10.56 -0.39 3.86e-24 Bipolar disorder; BRCA cis rs7520050 0.966 rs1707304 chr1:46598269 C/A cg24296786 chr1:45957014 TESK2 0.4 8.89 0.33 6.41e-18 Red blood cell count;Reticulocyte count; BRCA cis rs12477438 0.798 rs4622780 chr2:99631760 C/G cg08885076 chr2:99613938 TSGA10 -0.6 -13.12 -0.46 5.45e-35 Chronic sinus infection; BRCA cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg06532163 chr17:45867833 NA 0.39 7.94 0.3 9.3e-15 IgG glycosylation; BRCA cis rs6728642 0.908 rs10207116 chr2:98018281 G/A cg26665480 chr2:98280029 ACTR1B -0.54 -8.54 -0.32 9.9900000000000006e-17 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs4285028 0.747 rs7648343 chr3:121426195 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.86 -15.22 -0.52 7.62e-45 Multiple sclerosis; BRCA cis rs870825 0.929 rs871253 chr4:185589234 G/A cg04058563 chr4:185651563 MLF1IP 0.7 11.61 0.42 1.99e-28 Blood protein levels; BRCA cis rs600231 0.706 rs4244811 chr11:65320780 G/A cg17120908 chr11:65337727 SSSCA1 0.55 9.97 0.37 7.12e-22 Bone mineral density; BRCA cis rs2439831 0.850 rs28413704 chr15:44148427 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.73 12.76 0.45 2.23e-33 Lung cancer in ever smokers; BRCA cis rs35306767 0.903 rs35567307 chr10:915804 G/C cg26597838 chr10:835615 NA 1.02 18.05 0.58 3.47e-59 Eosinophil percentage of granulocytes; BRCA cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg23422044 chr7:1970798 MAD1L1 0.6 11.16 0.4 1.53e-26 Bipolar disorder; BRCA cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.63 0.5 5.25e-42 Personality dimensions; BRCA cis rs919433 0.648 rs6434933 chr2:198426960 G/A cg00792783 chr2:198669748 PLCL1 0.36 8.33 0.31 5.03e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg07256732 chr16:621771 PIGQ -0.35 -9.51 -0.35 3.68e-20 Height; BRCA cis rs17376456 0.877 rs10066791 chr5:93350255 G/T cg25358565 chr5:93447407 FAM172A 1.21 18.81 0.6 3.62e-63 Diabetic retinopathy; BRCA trans rs6011368 0.792 rs6512309 chr20:62892584 A/G cg13869341 chr1:15865 WASH5P 0.35 7.97 0.3 7.32e-15 Clozapine-induced cytotoxicity; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg25036284 chr2:26402008 FAM59B -0.66 -11.21 -0.41 9.28e-27 Gut microbiome composition (summer); BRCA cis rs1865721 0.771 rs72975985 chr18:73127648 C/T cg26385618 chr18:73139727 C18orf62 -0.43 -10.29 -0.38 4.6e-23 Intelligence; BRCA cis rs12682352 0.602 rs4841044 chr8:8664940 A/G cg15556689 chr8:8085844 FLJ10661 -0.39 -10.16 -0.37 1.36e-22 Neuroticism; BRCA cis rs4363385 0.747 rs4845506 chr1:152968407 G/A cg21543102 chr1:152974771 SPRR3 -0.3 -8.3 -0.31 6.13e-16 Inflammatory skin disease; BRCA cis rs765787 0.530 rs4238376 chr15:45541887 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.58 -0.42 2.68e-28 Uric acid levels; BRCA cis rs7772486 0.846 rs866473 chr6:146353414 A/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.33 -0.31 4.89e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.76 0.48 6.16e-38 Platelet count; BRCA cis rs738322 0.532 rs9622746 chr22:38564041 C/G cg20207973 chr22:38506712 BAIAP2L2 0.38 9.28 0.34 2.55e-19 Cutaneous nevi; BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg12444411 chr7:2802554 GNA12 -0.33 -8.08 -0.3 3.3e-15 Height; BRCA cis rs12142240 0.698 rs17361791 chr1:46812519 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs1707322 0.963 rs11211238 chr1:46449415 G/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg25767906 chr1:53392781 SCP2 -0.38 -8.61 -0.32 5.89e-17 Monocyte count; BRCA cis rs826838 0.967 rs1684415 chr12:39130099 T/C cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs9814567 0.896 rs10935123 chr3:134345327 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.83 -0.58 5.39e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs2262909 0.962 rs422344 chr19:22230956 C/G cg17074339 chr11:11642133 GALNTL4 0.41 7.86 0.3 1.63e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs17376456 0.877 rs10060462 chr5:93455073 C/T cg21475434 chr5:93447410 FAM172A 0.7 9.03 0.34 2.02e-18 Diabetic retinopathy; BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg12311346 chr5:56204834 C5orf35 -0.79 -15.31 -0.52 2.62e-45 Initial pursuit acceleration; BRCA cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 8.9 0.33 5.81e-18 Personality dimensions; BRCA cis rs6087990 0.735 rs2424928 chr20:31388636 T/C cg13636640 chr20:31349939 DNMT3B 0.62 17.13 0.56 2.03e-54 Ulcerative colitis; BRCA cis rs9733 0.596 rs72702570 chr1:150688196 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs17270561 0.636 rs6456698 chr6:25741664 A/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs16958440 0.867 rs58061761 chr18:44686165 T/C cg17192377 chr18:44677553 HDHD2 1.0 13.6 0.47 3.59e-37 Sitting height ratio; BRCA cis rs7639513 0.767 rs9878151 chr3:12703714 G/C cg23032965 chr3:12705835 RAF1 0.71 15.64 0.53 6.21e-47 Itch intensity from mosquito bite; BRCA cis rs7727544 0.582 rs10478998 chr5:131516531 G/A cg14196790 chr5:131705035 SLC22A5 0.37 9.16 0.34 6.91e-19 Blood metabolite levels; BRCA cis rs79387448 0.638 rs7600961 chr2:103035455 G/A cg09003973 chr2:102972529 NA 0.52 7.88 0.3 1.46e-14 Gut microbiota (bacterial taxa); BRCA cis rs7246657 0.943 rs12709813 chr19:37844983 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA trans rs11098499 0.697 rs4373140 chr4:120307698 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs2204008 0.645 rs9989043 chr12:38238505 G/A cg26384229 chr12:38710491 ALG10B -0.45 -10.12 -0.37 2.02e-22 Bladder cancer; BRCA cis rs12477438 0.520 rs34252185 chr2:99737646 A/G cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.34e-23 Chronic sinus infection; BRCA cis rs9329289 0.510 rs2029604 chr10:2554700 T/C cg15501526 chr10:2543763 NA 0.42 9.82 0.36 2.64e-21 Age-related hearing impairment; BRCA cis rs2797160 1.000 rs2747720 chr6:126009458 A/G cg05901451 chr6:126070800 HEY2 0.4 9.72 0.36 6.35e-21 Endometrial cancer; BRCA cis rs2762353 0.808 rs1165180 chr6:25826347 A/T cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs9309473 0.607 rs2421489 chr2:73593448 A/G cg20560298 chr2:73613845 ALMS1 -0.47 -12.84 -0.45 1.02e-33 Metabolite levels; BRCA cis rs7474896 0.559 rs1208779 chr10:38077729 A/C cg25427524 chr10:38739819 LOC399744 -0.54 -9.7 -0.36 7.57e-21 Obesity (extreme); BRCA cis rs9394931 1.000 rs9394931 chr6:42873245 C/T cg09436375 chr6:42928200 GNMT 0.23 7.99 0.3 6.16e-15 Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid); BRCA cis rs11690935 0.959 rs10167419 chr2:172649826 A/G cg13550731 chr2:172543902 DYNC1I2 -0.91 -31.24 -0.78 9.67e-131 Schizophrenia; BRCA cis rs7772486 0.790 rs1062068 chr6:146207465 A/G cg13319975 chr6:146136371 FBXO30 -0.42 -9.44 -0.35 7.12e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs34172651 0.517 rs189919 chr16:24737741 G/A cg00339695 chr16:24857497 SLC5A11 -0.48 -9.28 -0.34 2.66e-19 Intelligence (multi-trait analysis); BRCA cis rs1865721 0.804 rs3745084 chr18:73142510 T/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.39 -0.38 1.88e-23 Intelligence; BRCA cis rs9815354 0.716 rs76313799 chr3:41931751 A/C cg03022575 chr3:42003672 ULK4 0.69 9.5 0.35 4.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg13126279 chr21:47581558 C21orf56 -0.41 -9.03 -0.34 2e-18 Testicular germ cell tumor; BRCA cis rs4713118 0.621 rs9368548 chr6:28034737 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.29 8.29 0.31 6.83e-16 Parkinson's disease; BRCA cis rs4243830 0.850 rs10779787 chr1:6599755 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.88 -16.07 -0.54 4.79e-49 Body mass index; BRCA cis rs9814567 0.574 rs4974488 chr3:134168137 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.44 -12.91 -0.45 4.66e-34 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2835872 0.709 rs1709819 chr21:39036115 A/C cg06728970 chr21:39037746 KCNJ6 0.45 12.83 0.45 1.09e-33 Electroencephalographic traits in alcoholism; BRCA cis rs2016266 0.784 rs12424778 chr12:53737840 A/T cg26875137 chr12:53738046 NA 0.46 11.92 0.43 9.72e-30 Bone mineral density (spine);Bone mineral density; BRCA cis rs12188164 0.543 rs7728027 chr5:459943 T/C cg16584290 chr5:462447 EXOC3 0.54 15.19 0.52 9.91e-45 Cystic fibrosis severity; BRCA cis rs208520 1.000 rs12193164 chr6:66978962 C/T cg07460842 chr6:66804631 NA 0.87 14.19 0.49 6.35e-40 Exhaled nitric oxide output; BRCA cis rs9314323 0.862 rs3808580 chr8:26250296 C/T cg13160058 chr8:26243215 BNIP3L 0.43 11.5 0.41 6.0500000000000004e-28 Red cell distribution width; BRCA cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg04756594 chr16:24857601 SLC5A11 0.55 12.45 0.44 4.94e-32 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg06468780 chr21:31798236 KRTAP13-3 0.36 8.98 0.33 3.05e-18 HDL cholesterol; BRCA cis rs2180341 0.700 rs4598100 chr6:127565314 G/A cg27446573 chr6:127587934 RNF146 0.73 15.05 0.51 5.07e-44 Breast cancer; BRCA cis rs7267979 1.000 rs6138572 chr20:25435934 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.47 0.32 1.71e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7927771 0.965 rs4752881 chr11:47898535 A/G cg18512352 chr11:47633146 NA -0.34 -8.09 -0.3 2.98e-15 Subjective well-being; BRCA cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg20203395 chr5:56204925 C5orf35 -0.49 -10.35 -0.38 2.49e-23 Initial pursuit acceleration; BRCA cis rs17854409 0.881 rs6011430 chr20:61497014 C/T cg05147244 chr20:61493195 TCFL5 -0.73 -10.0 -0.37 5.79e-22 Obesity-related traits; BRCA cis rs12477438 0.798 rs6740267 chr2:99561867 T/C cg08885076 chr2:99613938 TSGA10 -0.6 -13.28 -0.47 1.04e-35 Chronic sinus infection; BRCA cis rs4927850 1.000 rs4927850 chr3:195751630 C/T cg12923728 chr3:195709715 SDHAP1 0.59 12.65 0.45 6.67e-33 Pancreatic cancer; BRCA trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg03929089 chr4:120376271 NA -0.53 -8.81 -0.33 1.21e-17 Axial length; BRCA cis rs3008870 0.755 rs2815380 chr1:67510857 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.59 -12.47 -0.44 4.37e-32 Lymphocyte percentage of white cells; BRCA cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg21770322 chr7:97807741 LMTK2 0.45 11.76 0.42 4.92e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg00074818 chr8:8560427 CLDN23 0.37 8.31 0.31 5.61e-16 Obesity-related traits; BRCA cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg06544989 chr22:39130855 UNC84B -0.38 -8.95 -0.33 3.74e-18 Menopause (age at onset); BRCA cis rs1865760 0.566 rs9358902 chr6:26058570 C/G cg16482183 chr6:26056742 HIST1H1C 0.56 11.79 0.42 3.48e-29 Height; BRCA cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg00701064 chr4:6280414 WFS1 0.68 17.63 0.57 5.63e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs11098499 0.909 rs28571712 chr4:120375980 G/A cg09307838 chr4:120376055 NA 0.72 15.37 0.52 1.39e-45 Corneal astigmatism; BRCA cis rs273218 1.000 rs156438 chr5:53374120 A/G ch.5.1024479R chr5:53302184 ARL15 0.41 8.44 0.32 2.13e-16 Migraine; BRCA cis rs4819052 0.918 rs2330013 chr21:46658662 G/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.65 11.58 0.42 2.82e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4919694 1.000 rs12253284 chr10:104665145 G/C cg04362960 chr10:104952993 NT5C2 0.93 14.96 0.51 1.31e-43 Arsenic metabolism; BRCA cis rs6831352 0.918 rs13127153 chr4:100058121 C/T cg13256891 chr4:100009986 ADH5 -0.53 -9.87 -0.36 1.82e-21 Alcohol dependence; BRCA cis rs6547741 1.000 rs6547740 chr2:27854369 C/T cg27432699 chr2:27873401 GPN1 0.39 8.31 0.31 5.63e-16 Oral cavity cancer; BRCA cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.34 -0.31 4.61e-16 Axial length; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg23719950 chr11:63933701 MACROD1 -0.59 -9.61 -0.36 1.65e-20 Mean platelet volume; BRCA cis rs7618501 0.602 rs2240326 chr3:50128386 G/A cg24110177 chr3:50126178 RBM5 0.37 10.12 0.37 1.98e-22 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 6.53e-87 Chronic sinus infection; BRCA cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.59 -0.35 1.86e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.818 rs11205164 chr1:152986023 A/T cg24667326 chr1:152973720 SPRR3 -0.32 -8.91 -0.33 5.26e-18 Inflammatory skin disease; BRCA cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg11644478 chr21:40555479 PSMG1 0.66 14.58 0.5 8.87e-42 Cognitive function; BRCA trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg15556689 chr8:8085844 FLJ10661 -0.35 -9.38 -0.35 1.12e-19 Retinal vascular caliber; BRCA cis rs2282802 0.685 rs11750229 chr5:139559014 T/G cg26211634 chr5:139558579 C5orf32 -0.34 -8.11 -0.31 2.56e-15 Intelligence (multi-trait analysis); BRCA cis rs739401 0.572 rs739399 chr11:3016452 A/G cg05729581 chr11:3078854 CARS -0.34 -8.41 -0.32 2.75e-16 Longevity; BRCA cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.68 -0.5 2.95e-42 Chronic sinus infection; BRCA cis rs6964587 0.626 rs35849169 chr7:91507313 A/G cg17063962 chr7:91808500 NA 0.53 12.22 0.44 5.31e-31 Breast cancer; BRCA cis rs3796352 1.000 rs11718834 chr3:52963668 A/C cg07884673 chr3:53033167 SFMBT1 0.74 9.15 0.34 7.57e-19 Immune reponse to smallpox (secreted IL-2); BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.52 -10.97 -0.4 9.19e-26 Lymphocyte counts; BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.59 -11.18 -0.4 1.27e-26 Gut microbiome composition (summer); BRCA cis rs9443645 0.901 rs9443632 chr6:79664440 T/C cg11833968 chr6:79620685 NA -0.43 -9.72 -0.36 6.42e-21 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs13246725 chr7:97914898 C/G cg21770322 chr7:97807741 LMTK2 0.42 11.31 0.41 3.74e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs3796619 1.000 rs4045481 chr4:1090625 C/T cg27284194 chr4:1044797 NA 0.41 8.93 0.33 4.59e-18 Recombination rate (males); BRCA cis rs6912958 0.703 rs12207825 chr6:88098292 C/T cg08069147 chr6:88032118 GJB7;C6orf162 0.58 12.04 0.43 3.27e-30 Monocyte percentage of white cells; BRCA cis rs7927771 0.524 rs9633830 chr11:47849470 T/G cg20307385 chr11:47447363 PSMC3 0.41 9.4 0.35 9.67e-20 Subjective well-being; BRCA cis rs208520 0.690 rs1318604 chr6:66825278 A/C cg07460842 chr6:66804631 NA -1.02 -20.03 -0.62 1.26e-69 Exhaled nitric oxide output; BRCA cis rs875971 1.000 rs7783613 chr7:65805261 C/T cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.23e-15 Aortic root size; BRCA cis rs11190604 0.725 rs9420796 chr10:102323092 G/C cg07080220 chr10:102295463 HIF1AN 0.52 12.01 0.43 4.25e-30 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg06494592 chr3:125709126 NA -0.53 -8.22 -0.31 1.17e-15 Blood pressure (smoking interaction); BRCA cis rs1511802 0.501 rs7661323 chr4:187115996 T/G cg24794857 chr4:187113578 CYP4V2 0.38 8.28 0.31 7.31e-16 Blood protein levels; BRCA cis rs911555 0.755 rs11620897 chr14:103944861 T/G cg24130564 chr14:104152367 KLC1 -0.39 -8.86 -0.33 8.08e-18 Intelligence (multi-trait analysis); BRCA cis rs9811920 0.638 rs796978 chr3:99564321 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.68 -15.52 -0.52 2.49e-46 Axial length; BRCA cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg21545522 chr1:205238299 TMCC2 0.4 8.38 0.31 3.31e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs3806843 1.000 rs2240692 chr5:140183585 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs7615952 0.673 rs35001498 chr3:125628644 A/G cg05084668 chr3:125655381 ALG1L -0.81 -11.23 -0.41 7.87e-27 Blood pressure (smoking interaction); BRCA cis rs2070488 0.804 rs7646429 chr3:38467713 A/G cg24069376 chr3:38537580 EXOG 0.33 9.08 0.34 1.32e-18 Electrocardiographic conduction measures; BRCA cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg02544614 chr20:61657117 NA 0.29 7.97 0.3 7.19e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.765 rs10181344 chr2:99692829 C/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg21724239 chr8:58056113 NA 0.45 8.01 0.3 5.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg01262667 chr19:19385393 TM6SF2 0.4 10.28 0.38 4.75e-23 Tonsillectomy; BRCA cis rs9290065 0.558 rs9846254 chr3:160770370 C/T cg03342759 chr3:160939853 NMD3 -0.53 -10.6 -0.39 2.68e-24 Kawasaki disease; BRCA cis rs7552404 1.000 rs4559448 chr1:76203456 A/G cg10523679 chr1:76189770 ACADM 0.76 15.96 0.53 1.62e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg08859206 chr1:53392774 SCP2 0.45 10.09 0.37 2.5e-22 Monocyte count; BRCA cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg26248373 chr2:1572462 NA -0.61 -13.78 -0.48 5.39e-38 IgG glycosylation; BRCA cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.26e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11098499 0.954 rs3733524 chr4:120423729 T/C cg09307838 chr4:120376055 NA 0.71 13.83 0.48 3.04e-38 Corneal astigmatism; BRCA cis rs13217239 0.646 rs4403259 chr6:26997617 C/T cg12292205 chr6:26970375 C6orf41 0.58 12.87 0.45 6.99e-34 Schizophrenia; BRCA cis rs2153535 0.580 rs1932279 chr6:8473653 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs7666738 0.830 rs13110410 chr4:98920018 T/C cg05340658 chr4:99064831 C4orf37 0.65 16.02 0.54 7.99e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs12549902 0.800 rs4736999 chr8:41506152 C/G cg21772509 chr8:41503840 NKX6-3 0.46 11.07 0.4 3.5e-26 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs7572733 0.534 rs1518361 chr2:198812874 A/G cg00792783 chr2:198669748 PLCL1 0.45 9.94 0.37 9.5e-22 Dermatomyositis; BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg08027265 chr7:2291960 NA -0.36 -8.37 -0.31 3.72e-16 Bipolar disorder and schizophrenia; BRCA cis rs847577 0.677 rs10242903 chr7:97741795 C/T cg21770322 chr7:97807741 LMTK2 -0.46 -12.3 -0.44 2.23e-31 Breast cancer; BRCA cis rs4722166 0.598 rs35658589 chr7:22800435 C/A cg05472934 chr7:22766657 IL6 0.39 9.69 0.36 8.47e-21 Lung cancer; BRCA trans rs7824557 0.872 rs2572431 chr8:11105077 C/T cg15556689 chr8:8085844 FLJ10661 -0.31 -8.14 -0.31 2.15e-15 Retinal vascular caliber; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg16606324 chr3:10149918 C3orf24 0.46 9.37 0.35 1.18e-19 Alzheimer's disease; BRCA cis rs7172677 1.000 rs4243032 chr15:75426884 C/G cg14664628 chr15:75095509 CSK -0.4 -8.32 -0.31 5.16e-16 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs4319547 1.000 rs7309390 chr12:123110422 A/G cg05707623 chr12:122985044 ZCCHC8 -0.46 -9.44 -0.35 6.73e-20 Body mass index; BRCA cis rs2243480 1.000 rs10247526 chr7:65780696 T/G cg18252515 chr7:66147081 NA 1.06 15.88 0.53 3.95e-48 Diabetic kidney disease; BRCA cis rs7394190 0.810 rs7394178 chr10:75421580 G/A cg07699608 chr10:75541558 CHCHD1 0.54 8.66 0.32 3.95e-17 Incident atrial fibrillation; BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg11814155 chr7:99998594 ZCWPW1 0.45 8.1 0.31 2.86e-15 Platelet count; BRCA cis rs6815814 0.799 rs11466640 chr4:38778903 A/G cg02016764 chr4:38805732 TLR1 0.5 7.85 0.3 1.82e-14 Breast cancer; BRCA trans rs17685 0.712 rs9800948 chr7:75810473 A/G cg19862616 chr7:65841803 NCRNA00174 0.77 23.8 0.69 4.16e-90 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg13944838 chr5:179740914 GFPT2 -0.69 -14.59 -0.5 7.57e-42 Height; BRCA cis rs17376456 0.825 rs10051878 chr5:93064164 T/G cg25358565 chr5:93447407 FAM172A 1.15 17.79 0.58 8.61e-58 Diabetic retinopathy; BRCA cis rs9291683 0.551 rs62295971 chr4:9978142 G/A cg02734326 chr4:10020555 SLC2A9 0.35 7.84 0.3 1.9e-14 Bone mineral density; BRCA cis rs2425143 0.818 rs6060726 chr20:34555878 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.01 -0.3 5.5e-15 Blood protein levels; BRCA cis rs7520050 0.966 rs12405451 chr1:46384326 T/A cg24296786 chr1:45957014 TESK2 0.44 9.76 0.36 4.46e-21 Red blood cell count;Reticulocyte count; BRCA cis rs3858526 0.883 rs1453429 chr11:5933478 C/T cg25319279 chr11:5960081 NA -0.41 -8.05 -0.3 4.09e-15 DNA methylation (variation); BRCA cis rs6942756 0.915 rs6966595 chr7:129006202 A/C cg02491457 chr7:128862824 NA -0.62 -12.58 -0.45 1.45e-32 White matter hyperintensity burden; BRCA cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg27129171 chr3:47204927 SETD2 0.72 17.76 0.57 1.24e-57 Colorectal cancer; BRCA cis rs7666738 0.830 rs1813972 chr4:98886828 C/A cg05340658 chr4:99064831 C4orf37 0.61 14.76 0.5 1.19e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg07930192 chr7:1003750 NA 0.41 8.82 0.33 1.1e-17 Longevity;Endometriosis; BRCA cis rs7927592 0.956 rs11228256 chr11:68251460 G/A cg20283391 chr11:68216788 NA -0.45 -8.88 -0.33 6.46e-18 Total body bone mineral density; BRCA cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg24977027 chr2:88469347 THNSL2 0.56 9.56 0.35 2.4e-20 Plasma clusterin levels; BRCA cis rs6545883 0.965 rs12713439 chr2:61752154 G/A cg15711740 chr2:61764176 XPO1 -0.55 -14.17 -0.49 7.9e-40 Tuberculosis; BRCA cis rs72772090 0.539 rs11741100 chr5:96113245 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.18 -0.43 8.07e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg16325326 chr1:53192061 ZYG11B -0.91 -24.89 -0.7 3.95e-96 Monocyte count; BRCA cis rs751728 1.000 rs751728 chr6:33764033 C/T cg25922239 chr6:33757077 LEMD2 0.6 15.96 0.53 1.69e-48 Crohn's disease; BRCA cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg25208724 chr1:156163844 SLC25A44 1.05 34.41 0.81 1.4e-147 Testicular germ cell tumor; BRCA cis rs2235642 0.653 rs7197288 chr16:1654753 C/A cg09065629 chr16:1709722 CRAMP1L 0.35 8.02 0.3 5.2e-15 Coronary artery disease; BRCA cis rs7100689 0.622 rs2342816 chr10:82086546 G/A cg01528321 chr10:82214614 TSPAN14 0.81 17.21 0.56 8.09e-55 Post bronchodilator FEV1; BRCA cis rs757110 0.526 rs757081 chr11:17351683 C/G cg15432903 chr11:17409602 KCNJ11 -0.57 -11.16 -0.4 1.5e-26 Type 2 diabetes; BRCA cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg14863265 chr7:2801509 GNA12 -0.42 -9.65 -0.36 1.2e-20 Height; BRCA cis rs7586879 0.796 rs10187348 chr2:25078415 G/C cg04586622 chr2:25135609 ADCY3 0.36 8.66 0.32 3.71e-17 Body mass index; BRCA cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg02297831 chr4:17616191 MED28 0.38 8.98 0.33 3.06e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg26384229 chr12:38710491 ALG10B -0.62 -15.95 -0.53 1.75e-48 Heart rate; BRCA cis rs6973256 0.605 rs6467499 chr7:133348922 G/T cg07491979 chr7:133331646 EXOC4 -0.35 -7.94 -0.3 8.8e-15 Intelligence (multi-trait analysis); BRCA cis rs7301016 1.000 rs11520127 chr12:62906965 C/G cg01804193 chr12:63026212 NA 0.46 7.95 0.3 8.27e-15 IgG glycosylation; BRCA cis rs6542838 0.641 rs4499468 chr2:99475204 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.19 -0.31 1.46e-15 Fear of minor pain; BRCA cis rs514406 0.708 rs536621 chr1:53309097 A/G cg01802117 chr1:53393560 SCP2 -0.4 -9.0 -0.34 2.62e-18 Monocyte count; BRCA cis rs12477438 0.765 rs62156363 chr2:99693324 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs11971779 0.523 rs10234578 chr7:139037988 T/C cg07862535 chr7:139043722 LUC7L2 0.39 10.38 0.38 1.95e-23 Diisocyanate-induced asthma; BRCA cis rs9463078 0.874 rs7743116 chr6:45142858 T/C cg25276700 chr6:44698697 NA -0.36 -8.17 -0.31 1.61e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9986765 1.000 rs73725075 chr7:142823479 C/A cg21852589 chr7:142981689 TMEM139 0.56 9.69 0.36 8.1899999999999992e-21 Cancer;Dermatomyositis; BRCA cis rs2637030 0.559 rs256087 chr5:52895233 G/A cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs10479542 0.892 rs7723230 chr5:178980474 T/C cg09060608 chr5:178986726 RUFY1 0.54 13.2 0.46 2.49e-35 Lung cancer; BRCA trans rs208520 1.000 rs12195505 chr6:66986279 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.46 0.5 3.3e-41 Exhaled nitric oxide output; BRCA cis rs4319547 0.737 rs10846920 chr12:122943231 C/T cg05707623 chr12:122985044 ZCCHC8 -0.39 -8.07 -0.3 3.52e-15 Body mass index; BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.95 -0.46 3.08e-34 Lymphocyte counts; BRCA cis rs9486715 0.758 rs9386528 chr6:96928514 G/A cg06623918 chr6:96969491 KIAA0776 -0.81 -18.18 -0.58 7.68e-60 Headache; BRCA cis rs8062405 0.964 rs62036614 chr16:28824685 T/C cg09754948 chr16:28834200 ATXN2L 0.45 8.32 0.31 5.46e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7481584 0.624 rs413368 chr11:3047646 C/G cg08508325 chr11:3079039 CARS 0.28 8.49 0.32 1.5e-16 Calcium levels; BRCA cis rs2832191 0.632 rs1984011 chr21:30337831 T/A cg24692254 chr21:30365293 RNF160 -0.79 -21.89 -0.65 1.13e-79 Dental caries; BRCA cis rs724568 0.546 rs1430769 chr2:67932210 A/T cg14046302 chr2:67939758 NA -0.39 -10.27 -0.38 5.11e-23 Major depressive disorder (broad); BRCA cis rs13046373 0.535 rs2832964 chr21:32014012 A/C cg16431978 chr21:31797932 KRTAP13-3 0.35 8.95 0.33 3.81e-18 HDL cholesterol; BRCA cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 8.63 0.32 4.76e-17 Bipolar disorder; BRCA cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg14847009 chr1:175162515 KIAA0040 0.25 9.63 0.36 1.38e-20 Alcohol dependence; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 20.05 0.62 9.49e-70 Platelet count; BRCA cis rs858239 0.539 rs6945510 chr7:23192240 C/T cg23682824 chr7:23144976 KLHL7 0.41 10.95 0.4 1.06e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs6582630 0.573 rs12319414 chr12:38267440 T/C cg26384229 chr12:38710491 ALG10B -0.43 -9.98 -0.37 6.84e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg13010199 chr12:38710504 ALG10B 0.51 9.9 0.36 1.35e-21 Bladder cancer; BRCA cis rs2242116 0.796 rs7623898 chr3:46974172 C/T cg27129171 chr3:47204927 SETD2 -0.65 -14.4 -0.49 6.44e-41 Birth weight; BRCA cis rs924607 1.000 rs1697978 chr5:642829 A/G cg04476341 chr5:669733 TPPP 0.39 10.62 0.39 2.17e-24 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs7917772 0.503 rs7915589 chr10:104299264 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.11 0.62 4.61e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs250677 0.687 rs250663 chr5:148453117 T/C cg12140854 chr5:148520817 ABLIM3 -0.42 -8.87 -0.33 7e-18 Breast cancer; BRCA cis rs16866061 0.515 rs1027340 chr2:225370554 C/A cg12698349 chr2:225449008 CUL3 0.84 28.94 0.75 2.66e-118 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs1865721 1.000 rs8096298 chr18:73187608 C/T cg26385618 chr18:73139727 C18orf62 -0.4 -9.1 -0.34 1.14e-18 Intelligence; BRCA cis rs12617721 0.718 rs72819964 chr2:99019138 T/C cg10123293 chr2:99228465 UNC50 0.51 8.9 0.33 5.8e-18 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs1005277 0.522 rs289650 chr10:37975505 G/T cg25427524 chr10:38739819 LOC399744 -0.61 -14.71 -0.5 2.18e-42 Extrinsic epigenetic age acceleration; BRCA cis rs6088813 1.000 rs56306402 chr20:33937704 G/A cg14752227 chr20:34000481 UQCC -0.43 -9.15 -0.34 7.53e-19 Height; BRCA cis rs10465746 0.725 rs12070578 chr1:84349607 A/G cg10977910 chr1:84465055 TTLL7 0.62 13.31 0.47 7.37e-36 Obesity-related traits; BRCA cis rs72781680 1.000 rs72796337 chr2:24142957 G/A cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.42e-39 Lymphocyte counts; BRCA cis rs12579753 0.917 rs7132465 chr12:82205840 C/T cg07988820 chr12:82153109 PPFIA2 -0.5 -8.77 -0.33 1.58e-17 Resting heart rate; BRCA cis rs7255436 1.000 rs7255436 chr19:8433196 C/A cg10811474 chr19:8428787 ANGPTL4 -0.33 -8.24 -0.31 9.53e-16 HDL cholesterol; BRCA cis rs6089584 0.850 rs6089634 chr20:60632566 T/C cg13770153 chr20:60521292 NA -0.44 -9.73 -0.36 5.93e-21 Body mass index; BRCA cis rs12142240 0.698 rs12385695 chr1:46819021 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.15 0.31 1.97e-15 Menopause (age at onset); BRCA cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg01028140 chr2:1542097 TPO -0.57 -11.62 -0.42 1.91e-28 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7772486 0.754 rs2064185 chr6:146066814 G/A cg23711669 chr6:146136114 FBXO30 -0.8 -19.23 -0.61 2.22e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs250677 0.687 rs40522 chr5:148442295 G/A cg12140854 chr5:148520817 ABLIM3 -0.4 -8.47 -0.32 1.71e-16 Breast cancer; BRCA cis rs6963495 0.818 rs56055535 chr7:105163574 C/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs4718428 0.705 rs12536410 chr7:66254290 G/A cg12165864 chr7:66369176 NA -0.44 -9.77 -0.36 4.34e-21 Corneal structure; BRCA cis rs2675662 0.525 rs12264025 chr10:75494450 A/G cg23231163 chr10:75533350 FUT11 -0.33 -8.65 -0.32 4.07e-17 Psoriasis vulgaris;Psoriasis; BRCA cis rs2066819 1.000 rs77768890 chr12:56725121 A/G cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs1878931 0.624 rs28089 chr16:3446937 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.64 -9.67 -0.36 9.91e-21 Body mass index (adult); BRCA cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs6964587 0.967 rs28594877 chr7:91644070 C/T cg17063962 chr7:91808500 NA 0.57 13.47 0.47 1.4e-36 Breast cancer; BRCA trans rs17685 0.753 rs10264760 chr7:75749694 A/G cg19862616 chr7:65841803 NCRNA00174 0.83 27.5 0.74 1.81e-110 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10193935 0.901 rs13375 chr2:42559288 A/G cg27598129 chr2:42591480 NA -0.6 -10.38 -0.38 1.94e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA cis rs561341 1.000 rs1681718 chr17:30296445 G/A cg12193833 chr17:30244370 NA -0.54 -8.66 -0.32 3.95e-17 Hip circumference adjusted for BMI; BRCA trans rs783540 0.500 rs783541 chr15:83255061 T/C cg16105309 chr15:79090380 ADAMTS7 0.34 8.8 0.33 1.26e-17 Schizophrenia; BRCA cis rs7267979 1.000 rs2184000 chr20:25395878 G/A cg08601574 chr20:25228251 PYGB -0.34 -8.2 -0.31 1.31e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3772130 0.962 rs11719093 chr3:121487686 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.06 0.37 3.42e-22 Cognitive performance; BRCA cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg09658497 chr7:2847517 GNA12 -0.44 -8.79 -0.33 1.35e-17 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs68170813 0.559 rs1018947 chr7:106851939 A/T cg02696742 chr7:106810147 HBP1 -0.52 -8.66 -0.32 3.8e-17 Coronary artery disease; BRCA cis rs7818345 0.967 rs35029660 chr8:19308126 T/C cg11303988 chr8:19266685 CSGALNACT1 0.32 8.08 0.3 3.17e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs79839061 0.520 rs6842808 chr4:906903 C/T cg14530993 chr4:882597 GAK 0.53 9.85 0.36 2.1e-21 Intelligence (multi-trait analysis); BRCA cis rs6460942 0.915 rs17541242 chr7:12459068 A/G cg06484146 chr7:12443880 VWDE -0.75 -10.62 -0.39 2.31e-24 Coronary artery disease; BRCA cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg01256987 chr12:42539512 GXYLT1 -0.57 -11.69 -0.42 9.97e-29 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs17376456 1.000 rs61132622 chr5:93539684 G/A cg21475434 chr5:93447410 FAM172A 0.67 8.87 0.33 7.13e-18 Diabetic retinopathy; BRCA cis rs10416265 0.528 rs17884930 chr19:33595390 A/G cg17764715 chr19:33622953 WDR88 0.51 8.34 0.31 4.54e-16 Bone properties (heel); BRCA cis rs703842 1.000 rs10877014 chr12:58167661 A/G cg00677455 chr12:58241039 CTDSP2 0.64 15.73 0.53 2.4e-47 Multiple sclerosis; BRCA cis rs2070488 0.965 rs7433277 chr3:38529818 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 19.91 0.62 5.48e-69 Electrocardiographic conduction measures; BRCA cis rs4908760 0.965 rs7542312 chr1:8573471 G/C cg20416874 chr1:8611966 RERE -0.28 -7.98 -0.3 6.88e-15 Vitiligo; BRCA cis rs3892630 0.588 rs2287881 chr19:33333155 A/G cg22980127 chr19:33182716 NUDT19 -0.88 -19.76 -0.62 3.39e-68 Red blood cell traits; BRCA cis rs9486715 0.659 rs9399930 chr6:96854444 G/T cg06623918 chr6:96969491 KIAA0776 0.89 23.0 0.67 9.18e-86 Headache; BRCA cis rs6745190 0.575 rs6433892 chr2:181971237 A/G cg00481216 chr2:181971175 NA 0.38 8.93 0.33 4.34e-18 White blood cell count; BRCA cis rs7246657 0.943 rs3760825 chr19:37945601 C/T cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.88e-28 Coronary artery calcification; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg08132940 chr7:1081526 C7orf50 -0.59 -8.84 -0.33 9.29e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72781680 0.898 rs112985192 chr2:24102797 G/A cg08917208 chr2:24149416 ATAD2B 0.93 13.74 0.48 7.67e-38 Lymphocyte counts; BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.5 10.18 0.37 1.13e-22 Lymphocyte counts; BRCA cis rs12477438 1.000 rs12477438 chr2:99841085 T/G cg08885076 chr2:99613938 TSGA10 -0.46 -8.84 -0.33 8.97e-18 Chronic sinus infection; BRCA cis rs13256369 1.000 rs10098234 chr8:8576692 G/A cg18904891 chr8:8559673 CLDN23 0.58 11.3 0.41 4.07e-27 Obesity-related traits; BRCA cis rs8005677 1.000 rs4982706 chr14:23381697 C/T cg01529538 chr14:23388837 RBM23 0.42 11.47 0.41 8.31e-28 Cognitive ability (multi-trait analysis); BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs59698941 0.550 rs60042615 chr5:132193220 A/G cg14825688 chr5:132208181 LEAP2 -0.37 -8.67 -0.32 3.6e-17 Apolipoprotein A-IV levels; BRCA cis rs2204008 0.682 rs2320517 chr12:38259239 A/T cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs826838 0.874 rs10880943 chr12:38734317 C/T cg26384229 chr12:38710491 ALG10B 0.85 23.4 0.68 6.5e-88 Heart rate; BRCA cis rs9287719 0.967 rs6744599 chr2:10747013 C/G cg00105475 chr2:10696890 NA -0.41 -9.35 -0.35 1.4e-19 Prostate cancer; BRCA cis rs2522056 0.808 rs7704457 chr5:131744790 C/T cg24060327 chr5:131705240 SLC22A5 -0.53 -8.95 -0.33 3.79e-18 Lymphocyte counts;Fibrinogen; BRCA cis rs9443645 0.901 rs6937465 chr6:79570345 G/T cg05283184 chr6:79620031 NA -0.43 -11.33 -0.41 3.01e-27 Intelligence (multi-trait analysis); BRCA cis rs6964587 1.000 rs12333563 chr7:91667326 G/A cg17063962 chr7:91808500 NA 0.53 12.58 0.45 1.4e-32 Breast cancer; BRCA cis rs4722166 0.532 rs1880242 chr7:22759607 A/C cg05472934 chr7:22766657 IL6 -0.43 -10.56 -0.39 3.83e-24 Lung cancer; BRCA cis rs858239 0.676 rs3807459 chr7:23389751 T/C cg23682824 chr7:23144976 KLHL7 0.31 7.98 0.3 6.97e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg04450456 chr4:17643702 FAM184B 0.38 11.16 0.4 1.54e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs870825 0.616 rs55685500 chr4:185614810 G/A cg04058563 chr4:185651563 MLF1IP 0.87 16.66 0.55 5.07e-52 Blood protein levels; BRCA cis rs11764590 0.756 rs17132130 chr7:2108036 G/C cg02951883 chr7:2050386 MAD1L1 0.39 8.08 0.3 3.12e-15 Neuroticism; BRCA cis rs853679 0.628 rs9368560 chr6:28159960 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.26 7.97 0.3 7.2e-15 Depression; BRCA cis rs875971 0.522 rs1917563 chr7:65415647 C/T cg18876405 chr7:65276391 NA -0.71 -18.63 -0.59 3.31e-62 Aortic root size; BRCA cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg02275930 chr1:2372054 NA -0.36 -8.85 -0.33 8.82e-18 Schizophrenia; BRCA cis rs1707322 1.000 rs1707322 chr1:46505147 C/T cg03146154 chr1:46216737 IPP 0.45 10.13 0.37 1.87e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2204008 0.744 rs1115514 chr12:38280140 C/T cg26384229 chr12:38710491 ALG10B 0.66 15.28 0.52 3.89e-45 Bladder cancer; BRCA cis rs12612619 0.732 rs893790 chr2:27201857 T/C cg00617064 chr2:27272375 NA 0.32 8.39 0.31 3.17e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg04944784 chr2:26401820 FAM59B -0.68 -11.21 -0.41 9.65e-27 Gut microbiome composition (summer); BRCA cis rs1003719 0.788 rs7275582 chr21:38451130 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.62 14.59 0.5 7.97e-42 Eye color traits; BRCA cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg11663144 chr21:46675770 NA -0.59 -13.71 -0.48 1.05e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg09877947 chr5:131593287 PDLIM4 0.41 10.41 0.38 1.48e-23 Breast cancer; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.68 13.77 0.48 5.5e-38 Lymphocyte counts; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.54 -10.89 -0.4 1.89e-25 Lymphocyte counts; BRCA trans rs3857536 0.813 rs4710580 chr6:66935200 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.24e-15 Blood trace element (Cu levels); BRCA cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg00990874 chr7:1149470 C7orf50 -0.59 -11.89 -0.43 1.36e-29 Bronchopulmonary dysplasia; BRCA cis rs7523273 0.565 rs11118453 chr1:207887996 A/C cg22525895 chr1:207977042 MIR29B2 0.33 7.85 0.3 1.7e-14 Schizophrenia; BRCA trans rs2204008 0.774 rs7959048 chr12:37948276 T/A cg06521331 chr12:34319734 NA -0.51 -9.41 -0.35 8.45e-20 Bladder cancer; BRCA cis rs1348850 0.567 rs3770011 chr2:178537890 C/T cg22681709 chr2:178499509 PDE11A -0.41 -8.96 -0.33 3.65e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4302748 0.862 rs11971718 chr7:36184620 T/C cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs9420 0.528 rs11607122 chr11:57389737 G/A cg19752551 chr11:57585705 CTNND1 -0.38 -9.31 -0.35 1.95e-19 Schizophrenia; BRCA cis rs4908760 0.864 rs1463052 chr1:8701231 A/G cg20416874 chr1:8611966 RERE -0.28 -8.13 -0.31 2.27e-15 Vitiligo; BRCA cis rs11098499 0.909 rs6842762 chr4:120398236 A/T cg09307838 chr4:120376055 NA 0.72 15.33 0.52 2.14e-45 Corneal astigmatism; BRCA cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.51 -8.44 -0.32 2.16e-16 Schizophrenia; BRCA cis rs2842992 0.915 rs2842958 chr6:160108425 A/G cg11366901 chr6:160182831 ACAT2 0.77 14.97 0.51 1.25e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs3617 0.572 rs2245538 chr3:52852060 T/C cg11645453 chr3:52864694 ITIH4 0.37 9.57 0.35 2.21e-20 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs2742234 0.955 rs2075910 chr10:43614230 G/A cg02780029 chr10:43622663 RET -0.41 -10.09 -0.37 2.51e-22 Hirschsprung disease; BRCA cis rs9473147 0.543 rs9381578 chr6:47556634 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.62 0.36 1.56e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs9399135 0.967 rs4376365 chr6:135307740 T/C cg24558204 chr6:135376177 HBS1L 0.46 12.55 0.44 1.82e-32 Red blood cell count; BRCA cis rs7568458 0.709 rs11895401 chr2:85753847 C/T cg02493740 chr2:85810744 VAMP5 -0.51 -10.58 -0.39 3.16e-24 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7903847 0.642 rs11189183 chr10:99144321 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.7e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs4819052 0.851 rs2838842 chr21:46669217 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.23 0.49 3.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.1 0.56 2.83e-54 Bladder cancer; BRCA cis rs1707322 0.691 rs11211174 chr1:46220816 C/G cg06784218 chr1:46089804 CCDC17 0.51 12.14 0.43 1.2e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1534166 0.647 rs1464937 chr3:133536655 C/G cg27366882 chr3:133540807 NA -0.32 -8.01 -0.3 5.46e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs312273 0.522 rs1442182 chr12:41308829 T/A cg17827154 chr12:41323612 CNTN1 -0.35 -8.67 -0.32 3.63e-17 Bipolar disorder; BRCA cis rs6867032 0.527 rs4975792 chr5:2010496 T/G cg26168224 chr5:2018326 NA 0.44 11.71 0.42 8.05e-29 Gut microbiome composition (winter); BRCA cis rs10838687 1.000 rs4752979 chr11:47339180 A/G cg25783544 chr11:47291846 MADD 0.42 8.45 0.32 2.04e-16 Proinsulin levels; BRCA cis rs9296092 0.538 rs62407566 chr6:33535786 C/T cg13560919 chr6:33536144 NA -0.92 -19.27 -0.61 1.47e-65 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs72781680 0.898 rs2879640 chr2:24043573 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.11 0.34 1.04e-18 Lymphocyte counts; BRCA trans rs4650994 0.525 rs11806608 chr1:178511375 T/C cg05059571 chr16:84539110 KIAA1609 -0.58 -13.41 -0.47 2.58e-36 HDL cholesterol levels;HDL cholesterol; BRCA cis rs36051895 0.632 rs10815167 chr9:5150058 A/G cg02405213 chr9:5042618 JAK2 -0.44 -8.6 -0.32 6.14e-17 Pediatric autoimmune diseases; BRCA cis rs10751667 0.666 rs7395267 chr11:962326 C/A cg01483505 chr11:975446 AP2A2 0.33 8.98 0.33 2.93e-18 Alzheimer's disease (late onset); BRCA cis rs12497850 1.000 rs4858798 chr3:48727112 C/T cg07636037 chr3:49044803 WDR6 0.85 22.97 0.67 1.31e-85 Parkinson's disease; BRCA cis rs17253792 0.822 rs74935793 chr14:56143277 G/A cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs11098499 0.874 rs6832670 chr4:120118792 A/G cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.65e-26 Corneal astigmatism; BRCA cis rs7618501 0.602 rs2071207 chr3:50159844 T/C cg05623727 chr3:50126028 RBM5 -0.44 -10.64 -0.39 1.85e-24 Intelligence (multi-trait analysis); BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg21782813 chr7:2030301 MAD1L1 0.34 9.13 0.34 8.97e-19 Schizophrenia; BRCA cis rs9733 0.744 rs12568757 chr1:150729793 C/T cg18016565 chr1:150552671 MCL1 -0.37 -8.27 -0.31 7.78e-16 Tonsillectomy; BRCA cis rs910316 0.967 rs4384542 chr14:75658013 A/C cg23033748 chr14:75592666 NEK9 -0.39 -9.35 -0.35 1.44e-19 Height; BRCA cis rs7772486 0.727 rs2235481 chr6:146056848 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -15.46 -0.52 5.03e-46 Lobe attachment (rater-scored or self-reported); BRCA trans rs1493916 0.967 rs1389532 chr18:31392323 C/T cg15819921 chr19:927150 ARID3A -0.47 -9.04 -0.34 1.84e-18 Life satisfaction; BRCA cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg20684491 chr1:25596433 NA -0.33 -8.57 -0.32 7.51e-17 Erythrocyte sedimentation rate; BRCA cis rs10911232 0.507 rs4596846 chr1:182976034 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.75 0.55 1.71e-52 Hypertriglyceridemia; BRCA trans rs6089829 0.962 rs7273930 chr20:61666017 G/A cg17470723 chr8:74884337 TCEB1 0.41 8.88 0.33 6.78e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs372883 0.648 rs1153292 chr21:30689195 G/T cg24692254 chr21:30365293 RNF160 -0.47 -10.43 -0.38 1.23e-23 Pancreatic cancer; BRCA cis rs17711722 0.565 rs4275112 chr7:65198619 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.56 -12.29 -0.44 2.54e-31 Calcium levels; BRCA cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg05896524 chr21:47604654 C21orf56 -0.5 -10.21 -0.37 8.89e-23 Testicular germ cell tumor; BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.33e-23 Alzheimer's disease; BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg11814155 chr7:99998594 ZCWPW1 0.48 8.7 0.33 2.76e-17 Platelet count; BRCA cis rs9462027 0.606 rs2038841 chr6:34738203 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 7.8e-15 Systemic lupus erythematosus; BRCA cis rs8062405 0.824 rs62034326 chr16:28539293 A/G cg16576597 chr16:28551801 NUPR1 0.31 8.57 0.32 7.87e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7072216 0.763 rs1061437 chr10:100176154 C/T cg26618903 chr10:100175079 PYROXD2 -0.31 -8.84 -0.33 9.49e-18 Metabolite levels; BRCA cis rs701145 0.585 rs1713852 chr3:153795487 C/G cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA trans rs801193 0.569 rs7800620 chr7:66223688 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.89 0.3 1.31e-14 Aortic root size; BRCA cis rs17376456 1.000 rs13185608 chr5:93509688 T/G cg25358565 chr5:93447407 FAM172A 1.25 19.1 0.6 1.13e-64 Diabetic retinopathy; BRCA cis rs7666738 0.830 rs6532715 chr4:99016792 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.683 rs12370288 chr12:38127740 G/A cg06521331 chr12:34319734 NA -0.53 -9.52 -0.35 3.46e-20 Bladder cancer; BRCA cis rs4819052 0.851 rs2877019 chr21:46658647 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.95 0.37 8.73e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3806843 1.000 rs3822346 chr5:140187322 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.73 -0.36 5.87e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs769267 1.000 rs2301669 chr19:19453560 C/A cg01262667 chr19:19385393 TM6SF2 -0.41 -10.72 -0.39 9.03e-25 Tonsillectomy; BRCA cis rs365132 1.000 rs1700490 chr5:176402401 G/A cg16309518 chr5:176445507 NA -0.51 -13.06 -0.46 9.65e-35 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg13047869 chr3:10149882 C3orf24 0.59 12.34 0.44 1.65e-31 Alzheimer's disease; BRCA cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg23992470 chr4:843637 GAK -0.48 -8.13 -0.31 2.21e-15 Intelligence (multi-trait analysis); BRCA cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg23248424 chr5:179741104 GFPT2 -0.67 -14.23 -0.49 4.1e-40 Height; BRCA cis rs3849570 0.961 rs3772912 chr3:81698481 A/G cg07356753 chr3:81810745 GBE1 -0.41 -9.29 -0.34 2.39e-19 Waist circumference;Body mass index; BRCA cis rs9304742 0.962 rs12461778 chr19:53454963 T/A cg09915433 chr19:53449742 NA -0.74 -17.03 -0.56 6.96e-54 Psoriasis; BRCA cis rs6120849 0.615 rs11167248 chr20:33538721 G/T cg24642439 chr20:33292090 TP53INP2 0.6 10.37 0.38 2.13e-23 Protein C levels; BRCA cis rs1008375 1.000 rs917665 chr4:17668504 A/C cg16339924 chr4:17578868 LAP3 -0.57 -13.78 -0.48 5.18e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7647973 0.667 rs6446286 chr3:49681704 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.81 -0.3 2.3e-14 Menarche (age at onset); BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg13732083 chr21:47605072 C21orf56 0.38 8.1 0.31 2.84e-15 Testicular germ cell tumor; BRCA cis rs1044826 0.642 rs407958 chr3:139213632 T/C cg00490450 chr3:139108681 COPB2 0.45 8.82 0.33 1.07e-17 Obesity-related traits; BRCA cis rs514406 0.505 rs431427 chr1:53179094 C/A cg24675658 chr1:53192096 ZYG11B -0.65 -14.38 -0.49 8.03e-41 Monocyte count; BRCA cis rs897080 0.516 rs1067361 chr2:44661217 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 9.27 0.34 2.87e-19 Height; BRCA cis rs7264396 0.635 rs6058375 chr20:34531997 T/A cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.86 0.3 1.62e-14 Total cholesterol levels; BRCA cis rs4919694 1.000 rs77505796 chr10:104647774 A/T cg04362960 chr10:104952993 NT5C2 0.95 13.16 0.46 3.59e-35 Arsenic metabolism; BRCA trans rs615632 0.530 rs10092464 chr8:9804185 C/G cg15556689 chr8:8085844 FLJ10661 -0.35 -8.19 -0.31 1.47e-15 Neuroticism; BRCA trans rs801193 0.569 rs13226966 chr7:66233623 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.96 0.3 7.74e-15 Aortic root size; BRCA cis rs4595586 0.545 rs17546137 chr12:39401124 G/A cg26384229 chr12:38710491 ALG10B 0.55 11.66 0.42 1.23e-28 Morning vs. evening chronotype; BRCA cis rs12048904 0.619 rs10875346 chr1:101328083 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.79 19.04 0.6 2.27e-64 Multiple sclerosis; BRCA trans rs11098499 0.863 rs3775849 chr4:120450908 G/C cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs897984 0.609 rs55979739 chr16:31049155 A/G cg00531865 chr16:30841666 NA -0.36 -8.44 -0.32 2.18e-16 Dementia with Lewy bodies; BRCA cis rs672059 1.000 rs672059 chr1:183162539 G/A ch.1.3577855R chr1:183094577 LAMC1 0.38 8.67 0.32 3.46e-17 Hypertriglyceridemia; BRCA cis rs7246657 0.943 rs1035479 chr19:37893300 G/T cg18154014 chr19:37997991 ZNF793 -0.48 -9.52 -0.35 3.43e-20 Coronary artery calcification; BRCA cis rs1580019 0.885 rs4460269 chr7:32496445 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.73 15.87 0.53 4.42e-48 Cognitive ability; BRCA cis rs9467773 0.967 rs6456732 chr6:26514445 T/C cg09904177 chr6:26538194 HMGN4 0.56 18.45 0.59 3.08e-61 Intelligence (multi-trait analysis); BRCA cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg25237894 chr2:233734115 C2orf82 -0.29 -8.45 -0.32 1.96e-16 Coronary artery disease; BRCA cis rs6598955 0.671 rs11247904 chr1:26621804 G/A cg04990556 chr1:26633338 UBXN11 0.54 8.79 0.33 1.34e-17 Obesity-related traits; BRCA cis rs9633740 1.000 rs7922621 chr10:82251544 C/A cg01528321 chr10:82214614 TSPAN14 1.04 20.39 0.63 1.49e-71 Post bronchodilator FEV1; BRCA cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg20701182 chr2:24300061 SF3B14 0.68 12.61 0.45 1.04e-32 Lymphocyte counts; BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.7 0.57 2.51e-57 Platelet count; BRCA cis rs4689592 0.546 rs907523 chr4:7052777 A/G cg19539972 chr4:7069911 GRPEL1 0.67 15.87 0.53 4.58e-48 Monocyte percentage of white cells; BRCA cis rs727479 0.543 rs2414096 chr15:51529779 G/A cg19946085 chr15:51559439 CYP19A1 -0.29 -8.06 -0.3 3.77e-15 Estradiol levels; BRCA cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg01939980 chr4:1354348 KIAA1530 0.29 7.86 0.3 1.68e-14 Longevity; BRCA trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -14.18 -0.49 7.04e-40 Extrinsic epigenetic age acceleration; BRCA cis rs72928364 1.000 rs34999788 chr3:100617668 G/T cg10123952 chr3:100791384 NA 0.53 7.9 0.3 1.21e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2404602 0.647 rs36114653 chr15:77025393 G/A cg23625390 chr15:77176239 SCAPER -0.54 -12.79 -0.45 1.59e-33 Blood metabolite levels; BRCA cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg00071950 chr4:10020882 SLC2A9 0.6 14.68 0.5 2.83e-42 Bone mineral density; BRCA cis rs2230307 0.536 rs2784173 chr1:100639752 A/G cg24955406 chr1:100503596 HIAT1 -0.45 -8.49 -0.32 1.49e-16 Carotid intima media thickness; BRCA cis rs875971 0.545 rs1796217 chr7:66085918 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.53 -9.9 -0.36 1.36e-21 Aortic root size; BRCA trans rs11039798 0.591 rs74992349 chr11:49019252 G/A cg15704280 chr7:45808275 SEPT13 0.62 10.32 0.38 3.25e-23 Axial length; BRCA cis rs7918232 0.941 rs10741128 chr10:27411509 G/A cg14442939 chr10:27389572 ANKRD26 0.66 10.92 0.4 1.5e-25 Breast cancer; BRCA cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.68 -0.36 9.18e-21 Tonsillectomy; BRCA cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg23711669 chr6:146136114 FBXO30 -0.77 -17.95 -0.58 1.15e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs11947027 chr4:99005941 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 1.000 rs56404918 chr16:28846840 T/G cg16576597 chr16:28551801 NUPR1 0.3 8.44 0.32 2.14e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs965469 1.000 rs6051807 chr20:3350485 A/G cg25506879 chr20:3388711 C20orf194 -0.53 -9.76 -0.36 4.73e-21 IFN-related cytopenia; BRCA cis rs6433895 0.736 rs13020845 chr2:181987553 C/T cg00481216 chr2:181971175 NA 0.4 8.67 0.32 3.6e-17 Lymphocyte counts; BRCA cis rs11055008 0.620 rs12816452 chr12:12833006 A/T cg09462578 chr12:12878428 APOLD1 -0.39 -8.62 -0.32 5.32e-17 Pulse pressure; BRCA cis rs13217239 0.646 rs35691005 chr6:26972070 A/G cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Schizophrenia; BRCA trans rs9858542 1.000 rs9823546 chr3:49705512 T/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.25 -0.34 3.42e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7267979 1.000 rs2500432 chr20:25290512 A/C cg08601574 chr20:25228251 PYGB 0.38 8.93 0.33 4.41e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg16414030 chr3:133502952 NA -0.49 -11.47 -0.41 8.25e-28 Iron status biomarkers; BRCA cis rs6121246 0.909 rs7272062 chr20:30259145 A/G cg13852791 chr20:30311386 BCL2L1 0.86 17.08 0.56 3.77e-54 Mean corpuscular hemoglobin; BRCA cis rs460214 0.564 rs9979888 chr21:40022099 A/G cg21578987 chr21:40029669 ERG -0.35 -8.53 -0.32 1.05e-16 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs9790314 0.645 rs10936224 chr3:160902531 G/A cg04691961 chr3:161091175 C3orf57 -0.35 -8.16 -0.31 1.84e-15 Morning vs. evening chronotype; BRCA trans rs12517041 1.000 rs6891825 chr5:23299740 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.2e-14 Calcium levels; BRCA cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg18876405 chr7:65276391 NA -0.5 -11.14 -0.4 1.82e-26 Aortic root size; BRCA cis rs3733585 0.578 rs4466042 chr4:9955367 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.68e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg19847866 chr10:1019161 NA 0.56 11.99 0.43 5.19e-30 Response to angiotensin II receptor blocker therapy; BRCA cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.82 0.36 2.79e-21 Lung cancer in ever smokers; BRCA cis rs477692 0.905 rs555545 chr10:131411586 G/A cg05714579 chr10:131428358 MGMT 0.56 13.27 0.46 1.11e-35 Response to temozolomide; BRCA cis rs2204008 0.837 rs7301679 chr12:37989629 T/C cg13010199 chr12:38710504 ALG10B -0.4 -8.57 -0.32 7.58e-17 Bladder cancer; BRCA cis rs7520050 0.966 rs785494 chr1:46586626 C/A cg24296786 chr1:45957014 TESK2 0.41 9.12 0.34 1e-18 Red blood cell count;Reticulocyte count; BRCA cis rs4319547 0.695 rs10846699 chr12:122853073 A/G cg05707623 chr12:122985044 ZCCHC8 0.48 9.32 0.35 1.92e-19 Body mass index; BRCA cis rs738322 0.600 rs7286105 chr22:38557821 A/G cg25457927 chr22:38595422 NA -0.35 -12.86 -0.45 8.05e-34 Cutaneous nevi; BRCA cis rs12579753 0.917 rs7138651 chr12:82253615 A/G cg07988820 chr12:82153109 PPFIA2 0.47 7.93 0.3 9.96e-15 Resting heart rate; BRCA cis rs6908034 0.607 rs12525152 chr6:19809424 A/T cg02682789 chr6:19804855 NA 0.76 9.1 0.34 1.14e-18 Endometriosis;Deep ovarian and/or rectovaginal disease with dense adhesions; BRCA cis rs7833986 0.534 rs17813240 chr8:56925791 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.72 13.55 0.47 6.15e-37 Height; BRCA cis rs523522 0.962 rs12309824 chr12:120990582 A/C cg27279351 chr12:120934652 DYNLL1 0.57 13.17 0.46 3.12e-35 High light scatter reticulocyte count; BRCA cis rs4363385 0.818 rs11205176 chr1:153002481 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.42 -0.32 2.38e-16 Inflammatory skin disease; BRCA cis rs4595586 0.545 rs1607041 chr12:39368206 C/T cg26384229 chr12:38710491 ALG10B 0.55 11.66 0.42 1.25e-28 Morning vs. evening chronotype; BRCA cis rs4713118 0.513 rs149954 chr6:28035246 G/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.19 0.31 1.45e-15 Parkinson's disease; BRCA cis rs6893300 0.785 rs3797762 chr5:179202688 A/G cg14593053 chr5:179126677 CANX -0.36 -8.02 -0.3 4.98e-15 Resting heart rate; BRCA cis rs8031584 0.958 rs1043742 chr15:31232581 A/C cg08109568 chr15:31115862 NA -0.44 -10.32 -0.38 3.28e-23 Huntington's disease progression; BRCA cis rs4363385 0.588 rs1577960 chr1:153025687 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.09 -0.3 3.08e-15 Inflammatory skin disease; BRCA cis rs7772486 0.806 rs2253648 chr6:146199296 G/A cg23711669 chr6:146136114 FBXO30 0.7 16.91 0.56 2.75e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs7188861 0.768 rs243315 chr16:11385011 C/T cg01510278 chr16:11456238 NA 0.42 8.1 0.31 2.71e-15 HDL cholesterol; BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.37 -8.17 -0.31 1.64e-15 Tonsillectomy; BRCA cis rs17270561 0.609 rs12529272 chr6:25731342 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs7666738 0.791 rs11097610 chr4:99011795 C/G cg17366294 chr4:99064904 C4orf37 0.44 10.33 0.38 3e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6942756 0.840 rs963465 chr7:128875612 C/G cg02491457 chr7:128862824 NA 0.6 13.19 0.46 2.51e-35 White matter hyperintensity burden; BRCA cis rs1348850 0.526 rs6723014 chr2:178410586 G/A cg27490568 chr2:178487706 NA 0.5 8.52 0.32 1.15e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9527 0.622 rs12779263 chr10:104886533 G/T cg04362960 chr10:104952993 NT5C2 0.49 10.92 0.4 1.44e-25 Arsenic metabolism; BRCA cis rs6598955 0.724 rs12726972 chr1:26639634 A/G cg04990556 chr1:26633338 UBXN11 0.62 14.25 0.49 3.45e-40 Obesity-related traits; BRCA cis rs1355223 0.583 rs1553757 chr11:34867089 G/A cg24088639 chr11:34937564 PDHX;APIP -0.41 -9.12 -0.34 9.46e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs35110281 0.811 rs2838339 chr21:45075750 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.48 -10.33 -0.38 3.18e-23 Mean corpuscular volume; BRCA cis rs701145 0.938 rs355770 chr3:154040273 G/A cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs514406 0.667 rs10788942 chr1:53210521 A/T cg08859206 chr1:53392774 SCP2 0.45 9.84 0.36 2.29e-21 Monocyte count; BRCA cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg06115741 chr20:33292138 TP53INP2 0.49 11.14 0.4 1.89e-26 Coronary artery disease; BRCA cis rs9527 0.615 rs7899622 chr10:104727333 C/T cg04362960 chr10:104952993 NT5C2 0.46 10.62 0.39 2.17e-24 Arsenic metabolism; BRCA cis rs9291683 0.935 rs1860911 chr4:10275057 C/T cg00071950 chr4:10020882 SLC2A9 0.46 11.21 0.41 9.43e-27 Bone mineral density; BRCA cis rs12995491 0.731 rs12992162 chr2:88508773 G/C cg14558114 chr2:88469736 THNSL2 -0.42 -9.19 -0.34 5.47e-19 Response to metformin (IC50); BRCA cis rs1499614 1.000 rs1267817 chr7:66110040 G/T cg18252515 chr7:66147081 NA -1.07 -15.74 -0.53 2.04e-47 Gout; BRCA trans rs1493916 0.870 rs1389531 chr18:31386616 C/T cg15819921 chr19:927150 ARID3A -0.47 -9.1 -0.34 1.13e-18 Life satisfaction; BRCA cis rs4900538 0.787 rs11704 chr14:102808655 C/G cg18135206 chr14:102964638 TECPR2 0.91 20.66 0.63 5.06e-73 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs35146811 0.586 rs6946168 chr7:99598286 C/T cg13334819 chr7:99746414 C7orf59 -0.37 -8.31 -0.31 5.77e-16 Coronary artery disease; BRCA cis rs4713118 0.739 rs2893931 chr6:27748010 G/A cg26587870 chr6:27730563 NA -0.41 -8.82 -0.33 1.13e-17 Parkinson's disease; BRCA cis rs6088590 0.561 rs6059918 chr20:33150503 C/T cg24642439 chr20:33292090 TP53INP2 0.56 12.33 0.44 1.82e-31 Coronary artery disease; BRCA cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg03213289 chr20:61660250 NA 0.61 16.16 0.54 1.63e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs9467773 1.000 rs10946835 chr6:26533757 C/T cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.791 rs372490 chr1:153008971 A/G cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs698813 0.805 rs804877 chr2:44702751 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.7 0.33 2.76e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg04166393 chr7:2884313 GNA12 0.52 10.02 0.37 4.63e-22 Height; BRCA trans rs9329221 0.537 rs2062331 chr8:9979992 C/T cg06636001 chr8:8085503 FLJ10661 -0.47 -10.13 -0.37 1.9e-22 Neuroticism; BRCA cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg26441486 chr22:50317300 CRELD2 0.32 8.54 0.32 9.9e-17 Schizophrenia; BRCA cis rs4689388 0.824 rs6446482 chr4:6295693 C/G cg00701064 chr4:6280414 WFS1 0.69 17.75 0.57 1.31e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs1814175 0.817 rs7947286 chr11:49874657 C/T cg03929089 chr4:120376271 NA -0.98 -29.5 -0.76 2.38e-121 Height; BRCA trans rs11098499 0.779 rs28495013 chr4:120375831 A/C cg25214090 chr10:38739885 LOC399744 0.56 12.8 0.45 1.55e-33 Corneal astigmatism; BRCA cis rs13256369 0.708 rs11249886 chr8:8562021 T/A cg17143192 chr8:8559678 CLDN23 0.57 11.29 0.41 4.39e-27 Obesity-related traits; BRCA cis rs2016266 0.787 rs61928080 chr12:53752204 G/A cg26875137 chr12:53738046 NA -0.43 -9.34 -0.35 1.5700000000000001e-19 Bone mineral density (spine);Bone mineral density; BRCA cis rs1552244 1.000 rs12374115 chr3:10134766 A/G cg00149659 chr3:10157352 C3orf10 -0.75 -12.91 -0.45 4.66e-34 Alzheimer's disease; BRCA cis rs13095912 1.000 rs35497918 chr3:185310312 C/T cg11274856 chr3:185301563 NA 0.34 8.53 0.32 1.1e-16 Systolic blood pressure; BRCA cis rs6835098 1.000 rs2332654 chr4:174088399 C/T cg08422745 chr4:174089978 GALNT7 -0.81 -17.82 -0.58 5.73e-58 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs7949030 1.000 rs10897289 chr11:62400016 T/C cg11742103 chr11:62369870 EML3;MTA2 0.39 9.61 0.36 1.57e-20 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs78456975 0.527 rs11901028 chr2:1557972 A/G cg26248373 chr2:1572462 NA -0.57 -12.92 -0.46 4.13e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1348850 0.519 rs1527406 chr2:178525655 C/T cg22681709 chr2:178499509 PDE11A -0.38 -8.22 -0.31 1.15e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9486719 0.656 rs4839826 chr6:96853616 A/G cg06623918 chr6:96969491 KIAA0776 -0.72 -15.57 -0.52 1.35e-46 Migraine;Coronary artery disease; BRCA cis rs7666738 0.830 rs4699592 chr4:98974202 A/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs7647973 0.554 rs13096480 chr3:49658084 A/G cg21659725 chr3:3221576 CRBN -0.48 -8.65 -0.32 4.23e-17 Menarche (age at onset); BRCA cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg20503657 chr10:835505 NA 1.01 15.7 0.53 3.27e-47 Eosinophil percentage of granulocytes; BRCA trans rs2262909 0.962 rs11667209 chr19:22259467 A/G cg17074339 chr11:11642133 GALNTL4 0.42 8.14 0.31 2.13e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs2742234 0.579 rs2503881 chr10:43686026 T/C cg15436174 chr10:43711423 RASGEF1A -0.54 -11.11 -0.4 2.36e-26 Hirschsprung disease; BRCA cis rs9858542 0.537 rs2304442 chr3:49322027 A/T cg00383909 chr3:49044727 WDR6 -0.42 -9.08 -0.34 1.32e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1008375 0.864 rs4698196 chr4:17574735 T/C cg04450456 chr4:17643702 FAM184B 0.38 9.93 0.37 1.09e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg06028605 chr16:24865363 SLC5A11 0.46 10.05 0.37 3.8e-22 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs7281767 chr21:32022062 T/C cg22337977 chr21:31811175 KRTAP15-1 0.33 7.86 0.3 1.6e-14 HDL cholesterol; BRCA cis rs17270561 0.609 rs7450798 chr6:25719280 T/A cg16482183 chr6:26056742 HIST1H1C 0.43 8.38 0.31 3.46e-16 Iron status biomarkers; BRCA cis rs4423214 0.765 rs2002064 chr11:71163420 A/G cg05163923 chr11:71159392 DHCR7 -0.55 -11.19 -0.4 1.2e-26 Vitamin D levels; BRCA cis rs12545109 0.879 rs1513317 chr8:57372966 C/G cg09654669 chr8:57350985 NA -0.46 -8.66 -0.32 3.82e-17 Obesity-related traits; BRCA cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg22029157 chr1:209979665 IRF6 0.56 12.49 0.44 3.54e-32 Cleft lip with or without cleft palate; BRCA cis rs13046373 0.535 rs9636840 chr21:32029979 A/G cg06468780 chr21:31798236 KRTAP13-3 -0.32 -7.89 -0.3 1.35e-14 HDL cholesterol; BRCA cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg12292205 chr6:26970375 C6orf41 0.64 14.45 0.5 3.77e-41 Autism spectrum disorder or schizophrenia; BRCA cis rs12142240 0.667 rs55887761 chr1:46826587 C/A cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs35306767 0.953 rs12259801 chr10:959306 C/G cg25019033 chr10:957182 NA -0.42 -8.73 -0.33 2.23e-17 Eosinophil percentage of granulocytes; BRCA cis rs6750047 0.541 rs162330 chr2:38319496 C/A cg07380506 chr2:38303506 CYP1B1 0.41 9.27 0.34 2.85e-19 Cutaneous malignant melanoma;Melanoma; BRCA cis rs3733585 0.631 rs7699671 chr4:10125874 C/T cg11266682 chr4:10021025 SLC2A9 -0.37 -9.37 -0.35 1.23e-19 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 21.09 0.64 2.41e-75 Platelet count; BRCA cis rs1707322 1.000 rs4660906 chr1:46470860 C/T cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.12e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1267303 0.642 rs11588450 chr1:47000996 C/T cg25110126 chr1:46999211 NA -0.54 -10.58 -0.39 3.19e-24 Monobrow; BRCA cis rs9811920 0.609 rs812657 chr3:99566329 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.38 8.38 0.31 3.42e-16 Axial length; BRCA cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11890956 chr21:40555474 PSMG1 -0.62 -13.86 -0.48 2.19e-38 Menarche (age at onset); BRCA cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg18446336 chr7:2847575 GNA12 -0.35 -8.4 -0.32 2.88e-16 Height; BRCA cis rs67460515 0.892 rs7647374 chr3:160975576 T/A cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Parkinson's disease; BRCA cis rs68170813 0.559 rs3815148 chr7:106938420 G/T cg02696742 chr7:106810147 HBP1 0.47 8.55 0.32 9.4e-17 Coronary artery disease; BRCA trans rs1973993 0.561 rs56983671 chr1:96988608 C/T cg10631902 chr5:14652156 NA -0.41 -10.11 -0.37 2.16e-22 Weight; BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.26 0.31 8.69e-16 Platelet count; BRCA cis rs9381040 0.655 rs2268190 chr6:41030226 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -8.97 -0.33 3.18e-18 Alzheimer's disease (late onset); BRCA cis rs12410462 1.000 rs75637482 chr1:227622944 A/T cg04117972 chr1:227635322 NA 0.48 8.67 0.32 3.58e-17 Major depressive disorder; BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.56 11.42 0.41 1.27e-27 Lymphocyte counts; BRCA cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg14343924 chr8:8086146 FLJ10661 0.4 8.25 0.31 9.1e-16 Mood instability; BRCA cis rs6582630 0.615 rs3914894 chr12:38480280 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.88 -0.36 1.65e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs7592578 0.771 rs4258824 chr2:191395027 C/T cg10560079 chr2:191398806 TMEM194B -0.72 -13.27 -0.46 1.14e-35 Diastolic blood pressure; BRCA cis rs34311866 0.808 rs4583705 chr4:973036 C/T cg07828340 chr4:882639 GAK 0.86 10.53 0.38 4.98e-24 Parkinson's disease; BRCA cis rs780096 0.546 rs715326 chr2:27725761 A/G cg22903471 chr2:27725779 GCKR 0.39 9.63 0.36 1.37e-20 Total body bone mineral density; BRCA cis rs79057730 0.599 rs4333501 chr7:803244 C/T cg06242242 chr7:766104 PRKAR1B;HEATR2 0.73 10.34 0.38 2.71e-23 Initial pursuit acceleration; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.99 -0.3 6.13e-15 Total body bone mineral density; BRCA cis rs7618915 0.501 rs2289247 chr3:52727257 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.53 -0.42 4.44e-28 Bipolar disorder; BRCA cis rs10927875 0.518 rs945416 chr1:16344402 G/A cg22431228 chr1:16359049 CLCNKA -0.44 -9.91 -0.37 1.19e-21 Dilated cardiomyopathy; BRCA cis rs11227306 0.934 rs7940691 chr11:65640906 C/T cg26695010 chr11:65641043 EFEMP2 0.36 7.91 0.3 1.17e-14 DNA methylation (variation); BRCA cis rs4727027 0.901 rs66800495 chr7:148763702 T/C cg23583168 chr7:148888333 NA -0.82 -18.5 -0.59 1.62e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg22903471 chr2:27725779 GCKR -0.36 -8.73 -0.33 2.29e-17 Total body bone mineral density; BRCA cis rs1577917 0.839 rs6454492 chr6:86483214 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.36 -9.33 -0.35 1.72e-19 Response to antipsychotic treatment; BRCA cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg21573476 chr21:45109991 RRP1B 0.37 9.18 0.34 5.89e-19 Mean corpuscular volume; BRCA cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg05234568 chr11:5960015 NA -0.51 -9.95 -0.37 8.59e-22 DNA methylation (variation); BRCA cis rs10463316 0.894 rs13357969 chr5:150751557 A/G cg03212797 chr5:150827313 SLC36A1 -0.45 -8.82 -0.33 1.04e-17 Metabolite levels (Pyroglutamine); BRCA cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg05084668 chr3:125655381 ALG1L -0.49 -9.3 -0.35 2.24e-19 Blood pressure (smoking interaction); BRCA trans rs9325144 0.555 rs2387843 chr12:38711203 T/C cg23762105 chr12:34175262 ALG10 -0.4 -9.83 -0.36 2.42e-21 Morning vs. evening chronotype; BRCA cis rs6570726 0.791 rs6570692 chr6:145904401 T/A cg23711669 chr6:146136114 FBXO30 0.74 17.43 0.57 5.6e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs34779708 0.931 rs35848945 chr10:35287561 G/T cg03585969 chr10:35415529 CREM 0.55 11.38 0.41 1.89e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg13010199 chr12:38710504 ALG10B 0.4 8.24 0.31 1e-15 Bladder cancer; BRCA cis rs332507 0.830 rs333355 chr3:124393595 A/G cg05980111 chr3:124395277 KALRN 0.32 7.84 0.3 1.84e-14 Plateletcrit; BRCA cis rs875971 0.862 rs13232191 chr7:65986648 A/G cg18876405 chr7:65276391 NA 0.5 11.07 0.4 3.5e-26 Aortic root size; BRCA cis rs4787491 0.679 rs7204852 chr16:30040178 C/G cg06326092 chr16:30034487 C16orf92 0.38 9.93 0.37 1.07e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.862 rs28491091 chr7:65669064 G/T cg18876405 chr7:65276391 NA -0.5 -11.23 -0.41 7.86e-27 Aortic root size; BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg21782813 chr7:2030301 MAD1L1 -0.34 -9.99 -0.37 6.38e-22 Bipolar disorder and schizophrenia; BRCA cis rs7312933 0.645 rs11181404 chr12:42683840 T/C cg01256987 chr12:42539512 GXYLT1 -0.42 -8.13 -0.31 2.19e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs8114671 0.967 rs3746427 chr20:33730464 A/G cg07148914 chr20:33460835 GGT7 0.41 8.57 0.32 7.83e-17 Height; BRCA trans rs7944735 0.517 rs11039520 chr11:48130794 A/G cg15704280 chr7:45808275 SEPT13 0.55 7.85 0.3 1.81e-14 Intraocular pressure; BRCA cis rs8114671 0.562 rs34837802 chr20:33424908 C/G cg24642439 chr20:33292090 TP53INP2 0.4 8.45 0.32 2e-16 Height; BRCA trans rs4650994 0.524 rs2811299 chr1:178586377 A/G cg05059571 chr16:84539110 KIAA1609 0.53 11.66 0.42 1.28e-28 HDL cholesterol levels;HDL cholesterol; BRCA cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg11584989 chr19:19387371 SF4 0.65 14.22 0.49 4.32e-40 Bipolar disorder; BRCA cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg08975724 chr8:8085496 FLJ10661 0.38 8.11 0.31 2.67e-15 Mood instability; BRCA cis rs6782228 0.606 rs2712419 chr3:128340896 T/C cg16766828 chr3:128327626 NA -0.42 -9.53 -0.35 3.08e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg08514558 chr10:81106712 PPIF 0.37 8.53 0.32 1.02e-16 Height; BRCA cis rs7119 0.717 rs11636412 chr15:77767291 C/T cg17802220 chr15:77601643 NA -0.47 -10.39 -0.38 1.81e-23 Type 2 diabetes; BRCA cis rs2243480 1.000 rs2961102 chr7:65424658 A/G cg18252515 chr7:66147081 NA -0.9 -12.92 -0.46 4.23e-34 Diabetic kidney disease; BRCA cis rs2180341 0.814 rs9321085 chr6:127735361 T/C cg27446573 chr6:127587934 RNF146 0.67 15.13 0.51 2.02e-44 Breast cancer; BRCA cis rs7809950 0.678 rs2395869 chr7:106940098 C/A cg23024343 chr7:107201750 COG5 -0.42 -9.07 -0.34 1.49e-18 Coronary artery disease; BRCA cis rs826838 0.904 rs1554550 chr12:39208889 G/A cg26384229 chr12:38710491 ALG10B 0.8 19.19 0.6 3.8e-65 Heart rate; BRCA cis rs9486719 0.948 rs6920913 chr6:96874297 A/G cg06623918 chr6:96969491 KIAA0776 0.72 14.12 0.49 1.31e-39 Migraine;Coronary artery disease; BRCA cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg26384229 chr12:38710491 ALG10B 0.74 17.78 0.58 9.46e-58 Drug-induced liver injury (flucloxacillin); BRCA cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg23583168 chr7:148888333 NA -0.96 -25.5 -0.71 1.85e-99 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2032447 0.899 rs1090947 chr6:26076642 T/C cg03264133 chr6:25882463 NA -0.5 -10.54 -0.38 4.63e-24 Intelligence (multi-trait analysis); BRCA cis rs7613875 0.521 rs4688754 chr3:50074641 G/T cg24110177 chr3:50126178 RBM5 0.5 14.23 0.49 4.17e-40 Body mass index; BRCA cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -12.23 -0.44 4.76e-31 Personality dimensions; BRCA cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.56 11.67 0.42 1.12e-28 Monocyte percentage of white cells; BRCA cis rs3008870 0.585 rs2815382 chr1:67515228 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.45 9.42 0.35 8.36e-20 Lymphocyte percentage of white cells; BRCA cis rs4319547 0.794 rs61954972 chr12:123074167 T/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.94 -0.37 9.99e-22 Body mass index; BRCA cis rs9309473 0.607 rs7573719 chr2:73582986 G/A cg20560298 chr2:73613845 ALMS1 -0.42 -10.98 -0.4 7.99e-26 Metabolite levels; BRCA cis rs910316 1.000 rs2098297 chr14:75619118 G/T cg23033748 chr14:75592666 NEK9 -0.43 -10.27 -0.38 5.45e-23 Height; BRCA cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg19717773 chr7:2847554 GNA12 -0.43 -9.71 -0.36 6.72e-21 Height; BRCA cis rs476633 0.691 rs2164996 chr15:41536624 A/G cg18705301 chr15:41695430 NDUFAF1 -0.4 -8.78 -0.33 1.5e-17 Glomerular filtration rate (creatinine); BRCA cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.85 0.42 1.99e-29 Homoarginine levels; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg23978390 chr7:1156363 C7orf50 0.49 11.22 0.41 8.56e-27 Longevity;Endometriosis; BRCA cis rs6977660 0.714 rs12700077 chr7:19791607 A/G cg07541023 chr7:19748670 TWISTNB -0.64 -10.52 -0.38 5.52e-24 Thyroid stimulating hormone; BRCA trans rs11039798 0.623 rs584851 chr11:48416321 A/G cg15704280 chr7:45808275 SEPT13 -0.55 -8.36 -0.31 3.98e-16 Axial length; BRCA cis rs9462027 0.628 rs7752060 chr6:34760325 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.93 -0.3 9.97e-15 Systemic lupus erythematosus; BRCA cis rs2836974 0.897 rs8133146 chr21:40614298 T/C cg11890956 chr21:40555474 PSMG1 1.06 29.94 0.76 9.99e-124 Cognitive function; BRCA cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg16423285 chr20:60520624 NA -0.4 -7.86 -0.3 1.68e-14 Body mass index; BRCA cis rs13082711 0.863 rs13062327 chr3:27495573 G/A cg02860705 chr3:27208620 NA 0.53 10.56 0.39 3.86e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs12168402 0.510 rs1076116 chr22:39237837 C/G cg06022373 chr22:39101656 GTPBP1 0.37 8.02 0.3 5.03e-15 Subjective well-being; BRCA cis rs1707322 1.000 rs785490 chr1:46577124 T/C cg03146154 chr1:46216737 IPP -0.45 -9.45 -0.35 6.07e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4595586 0.525 rs7972595 chr12:39338000 G/A cg26384229 chr12:38710491 ALG10B 0.55 11.33 0.41 2.96e-27 Morning vs. evening chronotype; BRCA cis rs7572263 0.724 rs6705133 chr2:209054422 G/A cg23998903 chr2:209048830 C2orf80 -0.42 -8.67 -0.32 3.43e-17 Glioma;Non-glioblastoma glioma; BRCA cis rs6582630 0.532 rs1589394 chr12:38419700 A/C cg26384229 chr12:38710491 ALG10B 0.48 11.32 0.41 3.27e-27 Drug-induced liver injury (flucloxacillin); BRCA cis rs765787 0.530 rs1648285 chr15:45517505 C/G cg15395560 chr15:45543142 SLC28A2 0.28 7.92 0.3 1.06e-14 Uric acid levels; BRCA cis rs2075371 0.871 rs418135 chr7:133949898 A/G cg11752832 chr7:134001865 SLC35B4 0.48 11.68 0.42 1.08e-28 Mean platelet volume; BRCA cis rs2204008 0.654 rs1290325 chr12:38152910 C/T cg26384229 chr12:38710491 ALG10B -0.47 -10.81 -0.39 4.07e-25 Bladder cancer; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg23131131 chr22:24373011 LOC391322 0.48 11.45 0.41 9.54e-28 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1941023 0.606 rs7946122 chr11:60172770 G/A cg08716584 chr11:60157161 MS4A7 -0.42 -9.73 -0.36 5.75e-21 Congenital heart disease (maternal effect); BRCA cis rs7588746 0.521 rs73054585 chr2:201144386 T/A cg23649088 chr2:200775458 C2orf69 -0.46 -8.06 -0.3 3.78e-15 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs3784262 0.669 rs12594082 chr15:58267779 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.24 -0.38 7.14e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs3739998 0.509 rs4749523 chr10:30332445 C/T cg00730780 chr10:30316187 KIAA1462 -0.54 -10.6 -0.39 2.79e-24 Coronary heart disease; BRCA cis rs10267417 0.657 rs6963367 chr7:19857873 A/C cg05791153 chr7:19748676 TWISTNB 0.51 9.79 0.36 3.43e-21 Night sleep phenotypes; BRCA cis rs11711311 1.000 rs9854504 chr3:113532381 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.34 8.71 0.33 2.69e-17 IgG glycosylation; BRCA cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg06046430 chr4:77819534 ANKRD56 0.62 13.94 0.48 9.77e-39 Emphysema distribution in smoking; BRCA cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg13010199 chr12:38710504 ALG10B -0.57 -12.66 -0.45 6.12e-33 Heart rate; BRCA cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg26769984 chr7:1090371 C7orf50 0.65 11.45 0.41 9.62e-28 Bronchopulmonary dysplasia; BRCA cis rs9399137 0.507 rs7745289 chr6:135380327 A/G cg22676075 chr6:135203613 NA 0.45 8.89 0.33 6.22e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs12621445 1 rs12621445 chr2:24154964 C/T cg20701182 chr2:24300061 SF3B14 0.67 9.81 0.36 2.93e-21 Immature fraction of reticulocytes; BRCA cis rs1153858 0.943 rs11070454 chr15:45680252 C/T cg21132104 chr15:45694354 SPATA5L1 0.76 17.04 0.56 6e-54 Homoarginine levels; BRCA cis rs6570726 0.818 rs437978 chr6:145809134 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.82 0.51 6.59e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.56 0.39 4.03e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 14.69 0.5 2.62e-42 Hip circumference adjusted for BMI; BRCA cis rs2072499 0.778 rs2247476 chr1:156190280 C/A cg25208724 chr1:156163844 SLC25A44 0.83 16.62 0.55 8.47e-52 Testicular germ cell tumor; BRCA cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg04455712 chr21:45112962 RRP1B 0.37 9.51 0.35 3.66e-20 Mean corpuscular volume; BRCA cis rs921968 0.565 rs1529382 chr2:219626489 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 5.95e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs10740039 0.804 rs1837950 chr10:62444965 C/T cg02922035 chr10:62493342 NA -0.42 -8.0 -0.3 5.8e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs11098499 0.954 rs13133522 chr4:120324424 A/T cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.56 -0.47 5.53e-37 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs9406164 chr6:8470048 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.747 rs1599386 chr3:160856314 C/T cg04691961 chr3:161091175 C3orf57 0.44 9.78 0.36 3.78e-21 Morning vs. evening chronotype; BRCA cis rs96067 0.772 rs2231318 chr1:36602943 C/T cg24686825 chr1:36642396 MAP7D1 -0.45 -8.58 -0.32 6.95e-17 Corneal structure; BRCA cis rs7552167 1.000 rs7552167 chr1:24518643 A/G cg01960748 chr1:24522592 NA -0.6 -10.3 -0.38 3.95e-23 Psoriasis vulgaris; BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.91 0.56 2.68e-53 Alzheimer's disease; BRCA trans rs783540 0.967 rs2870966 chr15:83295244 G/A cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.58 -0.32 7.32e-17 Schizophrenia; BRCA cis rs8114671 0.562 rs2076667 chr20:33506964 G/A cg24642439 chr20:33292090 TP53INP2 0.43 9.12 0.34 9.75e-19 Height; BRCA cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.72 -17.25 -0.56 5.06e-55 Chronic sinus infection; BRCA cis rs11098499 0.526 rs10026625 chr4:120280136 T/C cg09307838 chr4:120376055 NA 0.49 10.68 0.39 1.28e-24 Corneal astigmatism; BRCA cis rs1707322 0.752 rs11488313 chr1:46224780 G/C cg06784218 chr1:46089804 CCDC17 0.48 11.44 0.41 1.1e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg01849466 chr14:104193079 ZFYVE21 0.43 11.0 0.4 6.62e-26 Schizophrenia; BRCA cis rs35306767 0.951 rs61833265 chr10:990143 C/T cg20503657 chr10:835505 NA 1.04 17.35 0.57 1.6e-55 Eosinophil percentage of granulocytes; BRCA cis rs769267 0.930 rs6909 chr19:19619542 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.96 0.33 3.4e-18 Tonsillectomy; BRCA cis rs3213545 0.700 rs2260445 chr12:121468863 C/A cg02403541 chr12:121454288 C12orf43 0.56 12.1 0.43 1.71e-30 Subjective well-being;Cardiovascular disease risk factors; BRCA cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08109568 chr15:31115862 NA 0.57 14.58 0.5 8.98e-42 Huntington's disease progression; BRCA cis rs10838687 0.669 rs830084 chr11:47251652 T/C cg25783544 chr11:47291846 MADD -0.42 -7.96 -0.3 7.85e-15 Proinsulin levels; BRCA cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg04727924 chr7:799746 HEATR2 -0.53 -9.41 -0.35 8.8e-20 Cerebrospinal P-tau181p levels; BRCA trans rs1005277 0.579 rs1740732 chr10:38491385 C/T cg17830980 chr10:43048298 ZNF37B -0.53 -12.79 -0.45 1.59e-33 Extrinsic epigenetic age acceleration; BRCA cis rs9837602 1.000 rs9832186 chr3:99728503 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.05 0.4 4.21e-26 Breast cancer; BRCA cis rs1190552 0.846 rs11623570 chr14:102959277 G/T cg18135206 chr14:102964638 TECPR2 0.44 8.59 0.32 6.62e-17 Blood protein levels; BRCA cis rs6446731 0.593 rs2858083 chr4:3272331 T/A cg08886695 chr4:3369023 RGS12 -0.38 -9.95 -0.37 8.78e-22 Mean platelet volume; BRCA cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg05084668 chr3:125655381 ALG1L -0.47 -8.14 -0.31 2.08e-15 Blood pressure (smoking interaction); BRCA cis rs61931739 0.500 rs34107854 chr12:34482333 C/A cg06521331 chr12:34319734 NA -0.55 -10.09 -0.37 2.66e-22 Morning vs. evening chronotype; BRCA cis rs12762955 0.507 rs7095853 chr10:1040798 T/C cg20503657 chr10:835505 NA -0.52 -9.39 -0.35 1.06e-19 Response to angiotensin II receptor blocker therapy; BRCA trans rs7618501 0.521 rs6774354 chr3:49961780 G/A cg21659725 chr3:3221576 CRBN 0.35 8.39 0.32 3.19e-16 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.931 rs2109519 chr4:17695453 A/G cg02297831 chr4:17616191 MED28 0.36 8.5 0.32 1.39e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9815354 0.951 rs9849393 chr3:41875369 G/C cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs2635047 1.000 rs2635047 chr18:44736336 C/T cg19077165 chr18:44547161 KATNAL2 -0.37 -7.83 -0.3 2.01e-14 Educational attainment; BRCA cis rs9467773 1.000 rs1535277 chr6:26567802 G/T cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.8e-21 Intelligence (multi-trait analysis); BRCA cis rs703842 1.000 rs10877012 chr12:58162085 G/T cg18357645 chr12:58087776 OS9 -0.33 -8.34 -0.31 4.55e-16 Multiple sclerosis; BRCA cis rs1468333 1.000 rs4835671 chr5:137511801 C/T cg27119451 chr5:137514611 BRD8;KIF20A 0.45 8.7 0.33 2.9e-17 Resting heart rate; BRCA cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg00074818 chr8:8560427 CLDN23 0.37 8.29 0.31 6.69e-16 Obesity-related traits; BRCA cis rs6723226 0.732 rs390480 chr2:32510072 A/C cg02381751 chr2:32503542 YIPF4 -0.69 -15.11 -0.51 2.42e-44 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg24549020 chr5:56110836 MAP3K1 0.64 13.05 0.46 1.1e-34 Initial pursuit acceleration; BRCA cis rs7737355 0.947 rs6864145 chr5:130637861 C/T cg06307176 chr5:131281290 NA 0.45 8.67 0.32 3.65e-17 Life satisfaction; BRCA trans rs6076960 0.652 rs3852946 chr20:6255311 C/T cg21095983 chr6:86352623 SYNCRIP 0.37 8.68 0.32 3.41e-17 Smooth-surface caries; BRCA cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg03351412 chr1:154909251 PMVK 0.58 13.44 0.47 1.85e-36 Prostate cancer; BRCA cis rs9287719 0.699 rs4669602 chr2:10787967 C/T cg00105475 chr2:10696890 NA 0.36 8.4 0.32 2.93e-16 Prostate cancer; BRCA cis rs4742903 0.509 rs10991115 chr9:106896111 C/T cg14250997 chr9:106856677 SMC2 0.29 8.51 0.32 1.22e-16 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs6912958 0.559 rs1201409 chr6:88055264 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.57 12.2 0.43 6.11e-31 Monocyte percentage of white cells; BRCA cis rs10191773 0.535 rs56048537 chr2:113078467 G/T cg24977338 chr2:113188963 RGPD8;RGPD5 -0.55 -8.19 -0.31 1.39e-15 Yeast infection; BRCA trans rs3780486 0.522 rs10217770 chr9:33146393 C/A cg04842962 chr6:43655489 MRPS18A 0.84 21.48 0.65 1.86e-77 IgG glycosylation; BRCA cis rs11051970 0.636 rs2733705 chr12:32561564 T/C cg02745156 chr12:32552066 NA 0.25 8.4 0.32 2.93e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg08027265 chr7:2291960 NA -0.36 -8.23 -0.31 1.04e-15 Bipolar disorder and schizophrenia; BRCA cis rs11229555 0.645 rs12797488 chr11:58174653 A/T cg15696309 chr11:58395628 NA -0.53 -11.02 -0.4 5.84e-26 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs11098499 0.913 rs68128210 chr4:120137819 T/G cg25214090 chr10:38739885 LOC399744 0.53 10.82 0.39 3.7e-25 Corneal astigmatism; BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg21143896 chr7:2802374 GNA12 -0.32 -8.09 -0.3 3.05e-15 Height; BRCA cis rs2204008 0.683 rs11522927 chr12:38137537 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.96 0.37 8.22e-22 Bladder cancer; BRCA cis rs2576037 0.526 rs11082562 chr18:44522671 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.57 -11.79 -0.42 3.56e-29 Personality dimensions; BRCA cis rs6005807 0.640 rs2013784 chr22:28923933 C/T cg12565055 chr22:29076175 TTC28 -0.41 -8.03 -0.3 4.62e-15 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs1949733 0.958 rs3103069 chr4:8509451 T/G cg11789530 chr4:8429930 ACOX3 -0.69 -17.67 -0.57 3.35e-57 Response to antineoplastic agents; BRCA cis rs7301826 0.934 rs10848212 chr12:131322000 C/G cg11011512 chr12:131303247 STX2 -0.4 -9.76 -0.36 4.52e-21 Plasma plasminogen activator levels; BRCA cis rs208520 0.690 rs207107 chr6:66794385 T/C cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA cis rs1008375 1.000 rs114490726 chr4:17680898 T/C cg16339924 chr4:17578868 LAP3 0.59 14.52 0.5 1.8e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1011018 0.628 rs56840127 chr7:139438467 G/C cg03224163 chr7:139420300 HIPK2 -0.51 -9.0 -0.34 2.63e-18 Systolic blood pressure; BRCA cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg18132916 chr6:79620363 NA -0.47 -10.76 -0.39 6.33e-25 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs3087502 chr7:99955364 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.21 0.43 5.69e-31 Platelet count; BRCA cis rs10771431 1.000 rs11611670 chr12:9385535 C/T cg00504896 chr12:9437009 LOC642846 -0.49 -10.7 -0.39 1.12e-24 Breast size; BRCA cis rs12887734 0.546 rs12885509 chr14:104273325 T/C cg08213375 chr14:104286397 PPP1R13B 0.52 11.64 0.42 1.57e-28 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs4332037 0.802 rs73048106 chr7:1929019 G/T cg02743256 chr7:2109353 MAD1L1 -0.44 -7.86 -0.3 1.61e-14 Bipolar disorder; BRCA cis rs208520 0.690 rs12208310 chr6:66730108 G/C cg07460842 chr6:66804631 NA 0.98 19.65 0.61 1.36e-67 Exhaled nitric oxide output; BRCA cis rs11098499 0.754 rs1814813 chr4:120258207 G/T cg09307838 chr4:120376055 NA -0.62 -13.75 -0.48 7.48e-38 Corneal astigmatism; BRCA cis rs6866344 0.697 rs11748495 chr5:178130000 A/G cg03877680 chr5:178157825 ZNF354A -0.77 -14.38 -0.49 7.97e-41 Neutrophil percentage of white cells; BRCA cis rs34779708 0.966 rs35777088 chr10:35409048 T/C cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.98e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.58 -11.78 -0.42 3.86e-29 Tonsillectomy; BRCA cis rs2204008 0.837 rs11168334 chr12:37961768 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.26 0.56 4.21e-55 Bladder cancer; BRCA cis rs11626933 0.959 rs8005973 chr14:90774951 C/T cg04374321 chr14:90722782 PSMC1 0.43 8.63 0.32 4.93e-17 Gut microbiota (bacterial taxa); BRCA trans rs867371 0.519 rs1566560 chr15:82524457 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.32 -8.59 -0.32 6.76e-17 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs8014204 0.762 rs10139018 chr14:75274292 T/C cg06637938 chr14:75390232 RPS6KL1 0.42 8.6 0.32 6.1e-17 Caffeine consumption; BRCA cis rs9291683 0.554 rs7668175 chr4:10125782 T/C cg11266682 chr4:10021025 SLC2A9 -0.37 -9.61 -0.36 1.58e-20 Bone mineral density; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg22907277 chr7:1156413 C7orf50 0.6 9.01 0.34 2.28e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11711311 1.000 rs3732793 chr3:113442198 C/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.59 0.39 2.99e-24 IgG glycosylation; BRCA cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg04990556 chr1:26633338 UBXN11 -0.46 -8.91 -0.33 5.19e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs72772090 0.522 rs79613279 chr5:95995040 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -8.5 -0.32 1.3e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg05313129 chr8:58192883 C8orf71 -0.48 -9.83 -0.36 2.58e-21 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg02297831 chr4:17616191 MED28 0.39 8.64 0.32 4.47e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7809950 1.000 rs17154077 chr7:107077941 C/T cg23024343 chr7:107201750 COG5 0.4 9.35 0.35 1.41e-19 Coronary artery disease; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg11905131 chr22:24372483 LOC391322 -0.41 -8.92 -0.33 4.86e-18 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs6479891 0.778 rs7896676 chr10:65065302 T/C cg14819942 chr15:35414228 NA -0.35 -8.56 -0.32 8.37e-17 Arthritis (juvenile idiopathic); BRCA cis rs13095912 1.000 rs6784948 chr3:185342787 C/T cg11274856 chr3:185301563 NA 0.33 8.29 0.31 6.53e-16 Systolic blood pressure; BRCA cis rs6809651 0.524 rs4686728 chr3:185795333 C/T cg00760338 chr3:185826511 ETV5 0.5 10.29 0.38 4.44e-23 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs2075371 1.000 rs2598292 chr7:133988584 C/G cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.94e-23 Mean platelet volume; BRCA cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.42 0.47 2.35e-36 Colorectal cancer; BRCA cis rs7267979 1.000 rs7268053 chr20:25328286 A/T cg08601574 chr20:25228251 PYGB -0.35 -8.31 -0.31 5.95e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7301826 1.000 rs4759524 chr12:131315610 G/A cg11011512 chr12:131303247 STX2 0.43 10.95 0.4 1.1e-25 Plasma plasminogen activator levels; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.77 -0.33 1.58e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs1997103 0.871 rs1997101 chr7:55399652 A/T cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs3960554 0.867 rs76408713 chr7:75829540 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 11.78 0.42 3.93e-29 Eotaxin levels; BRCA cis rs10883723 0.773 rs7917402 chr10:104246690 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 19.68 0.61 9.55e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2153535 0.580 rs9406169 chr6:8509470 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.59 0.39 2.94e-24 Motion sickness; BRCA cis rs7772486 0.846 rs1474871 chr6:146406294 G/A cg23711669 chr6:146136114 FBXO30 0.67 15.63 0.53 7.2e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs929354 1.000 rs1182391 chr7:157038368 T/C cg17757837 chr7:157058334 UBE3C -0.69 -17.16 -0.56 1.43e-54 Body mass index; BRCA cis rs9733 0.650 rs11204684 chr1:150608894 A/G cg18016565 chr1:150552671 MCL1 -0.43 -9.61 -0.36 1.62e-20 Tonsillectomy; BRCA trans rs7980799 0.933 rs11052705 chr12:33588388 T/C cg26384229 chr12:38710491 ALG10B -0.41 -8.53 -0.32 1.05e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs17685 0.753 rs11764129 chr7:75761890 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg15541040 chr2:3486749 NA -0.47 -10.42 -0.38 1.39e-23 Neurofibrillary tangles; BRCA cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg25319279 chr11:5960081 NA 0.46 9.84 0.36 2.31e-21 DNA methylation (variation); BRCA cis rs2075371 1.000 rs1421485 chr7:133985181 C/T cg20476274 chr7:133979776 SLC35B4 0.65 19.4 0.61 2.78e-66 Mean platelet volume; BRCA cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.81 -0.3 2.42e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2280018 0.526 rs2966129 chr16:15152927 A/C cg27102117 chr16:15229624 NA -0.41 -9.76 -0.36 4.61e-21 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs72772090 0.539 rs56213813 chr5:96112284 A/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.08 -0.43 2.05e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7020830 0.861 rs2291589 chr9:37079661 T/G cg14294708 chr9:37120828 ZCCHC7 1.16 40.16 0.85 5.94e-177 Schizophrenia; BRCA cis rs919433 0.963 rs1896857 chr2:198164530 A/G cg10820045 chr2:198174542 NA -0.38 -8.38 -0.31 3.29e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs13102973 0.931 rs12499856 chr4:135868573 C/T cg14419869 chr4:135874104 NA 0.52 11.1 0.4 2.74e-26 Subjective well-being; BRCA trans rs1005277 0.589 rs2749624 chr10:38529865 A/G cg23533926 chr12:111358616 MYL2 -0.44 -9.2 -0.34 4.96e-19 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 1.000 rs12623496 chr2:24181583 C/T cg20701182 chr2:24300061 SF3B14 0.59 9.21 0.34 4.53e-19 Lymphocyte counts; BRCA cis rs10046574 0.519 rs7781819 chr7:135205700 A/T cg27474649 chr7:135195673 CNOT4 0.64 10.67 0.39 1.44e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6543140 0.964 rs4851589 chr2:103077145 A/G cg04239558 chr2:103089729 SLC9A4 0.31 8.74 0.33 2.11e-17 Blood protein levels; BRCA cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg15145296 chr3:125709740 NA -0.53 -9.12 -0.34 9.63e-19 Blood pressure (smoking interaction); BRCA cis rs7772486 0.875 rs969694 chr6:146394655 A/G cg23711669 chr6:146136114 FBXO30 0.65 14.88 0.51 3.11e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg23708337 chr7:1209742 NA 0.63 8.86 0.33 8.16e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg00071950 chr4:10020882 SLC2A9 -0.43 -9.96 -0.37 8.02e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs67460515 0.892 rs2054710 chr3:161090616 C/T cg04691961 chr3:161091175 C3orf57 -0.39 -8.71 -0.33 2.66e-17 Parkinson's disease; BRCA cis rs7772486 0.790 rs3924499 chr6:146232978 A/T cg13319975 chr6:146136371 FBXO30 0.4 8.95 0.33 3.88e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742234 0.541 rs12416428 chr10:43708998 G/A cg15436174 chr10:43711423 RASGEF1A 0.56 10.95 0.4 1.13e-25 Hirschsprung disease; BRCA cis rs1801251 0.778 rs778340 chr2:233734083 C/T cg25237894 chr2:233734115 C2orf82 -0.45 -14.46 -0.5 3.26e-41 Coronary artery disease; BRCA cis rs2242116 0.796 rs4683297 chr3:46973673 T/C cg27129171 chr3:47204927 SETD2 -0.65 -14.38 -0.49 8.17e-41 Birth weight; BRCA trans rs3857536 0.740 rs9354392 chr6:66894555 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.34 -0.35 1.63e-19 Blood trace element (Cu levels); BRCA cis rs9733 0.519 rs7511673 chr1:150707636 A/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.53e-15 Tonsillectomy; BRCA cis rs2153535 0.525 rs1335644 chr6:8488041 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA trans rs7618501 0.540 rs11130241 chr3:50131459 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.35 -9.84 -0.36 2.26e-21 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.966 rs3733576 chr4:17586703 T/C cg27347728 chr4:17578864 LAP3 0.45 8.81 0.33 1.18e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12497850 0.897 rs7432989 chr3:49105136 A/G cg06212747 chr3:49208901 KLHDC8B 0.47 9.51 0.35 3.87e-20 Parkinson's disease; BRCA cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg01884057 chr2:25150051 NA 0.31 8.25 0.31 9.38e-16 Body mass index; BRCA cis rs17125944 0.505 rs75194546 chr14:53212069 A/C cg13660082 chr14:53194042 PSMC6 -0.56 -8.05 -0.3 4.16e-15 Alzheimer's disease (late onset); BRCA cis rs2625529 0.824 rs12902006 chr15:72252996 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.46 -0.57 4.01e-56 Red blood cell count; BRCA cis rs698833 0.892 rs698797 chr2:44689905 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.61 0.39 2.38e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg18402987 chr7:1209562 NA 0.59 11.59 0.42 2.47e-28 Longevity;Endometriosis; BRCA cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.52 8.22 0.31 1.13e-15 Renal function-related traits (BUN); BRCA cis rs4074536 0.536 rs10923352 chr1:116290716 T/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA trans rs4332037 0.510 rs11762803 chr7:1886805 A/G cg11693508 chr17:37793320 STARD3 0.47 10.13 0.37 1.75e-22 Bipolar disorder; BRCA cis rs4713675 0.584 rs9380375 chr6:33682391 G/A cg14003231 chr6:33640908 ITPR3 0.35 8.72 0.33 2.3e-17 Plateletcrit; BRCA cis rs11785693 0.862 rs17351027 chr8:4987098 A/G cg26367366 chr8:4980734 NA -0.61 -11.21 -0.41 9.13e-27 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg11644478 chr21:40555479 PSMG1 -0.52 -10.93 -0.4 1.36e-25 Menarche (age at onset); BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg05348668 chr2:190686969 PMS1 -0.36 -7.93 -0.3 9.6e-15 Mosquito bite size; BRCA cis rs36051895 0.658 rs10975029 chr9:5251068 T/C cg02405213 chr9:5042618 JAK2 -0.45 -8.48 -0.32 1.6e-16 Pediatric autoimmune diseases; BRCA cis rs9311474 0.629 rs9853056 chr3:52555957 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.37 7.88 0.3 1.4e-14 Electroencephalogram traits; BRCA cis rs3740540 0.507 rs942014 chr10:126290070 C/T cg04949429 chr10:126290192 LHPP 0.43 12.05 0.43 2.72e-30 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg09074113 chr2:20870087 GDF7 0.32 8.3 0.31 6.3e-16 Abdominal aortic aneurysm; BRCA cis rs7786808 0.741 rs11765319 chr7:158226790 A/G cg09998033 chr7:158218633 PTPRN2 -0.37 -9.32 -0.35 1.8e-19 Obesity-related traits; BRCA cis rs4774830 0.661 rs62045239 chr15:56294642 G/A cg24530489 chr15:56299380 NA -0.8 -8.99 -0.34 2.82e-18 Delta-5 desaturase activity; BRCA cis rs933688 0.536 rs332537 chr5:90794973 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 -0.75 -13.22 -0.46 1.93e-35 Smoking behavior; BRCA cis rs1005277 0.579 rs2472176 chr10:38382921 T/C cg25427524 chr10:38739819 LOC399744 -0.7 -16.92 -0.56 2.46e-53 Extrinsic epigenetic age acceleration; BRCA cis rs2882667 0.690 rs700625 chr5:138099597 A/T cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6867032 0.527 rs4975777 chr5:1973324 G/T cg26168224 chr5:2018326 NA -0.51 -11.45 -0.41 1.01e-27 Gut microbiome composition (winter); BRCA trans rs7618501 0.902 rs7645061 chr3:49868842 C/T cg21582582 chr3:182698605 DCUN1D1 0.37 9.87 0.36 1.82e-21 Intelligence (multi-trait analysis); BRCA cis rs4908768 0.539 rs6670508 chr1:8647917 G/C cg20416874 chr1:8611966 RERE -0.28 -7.83 -0.3 2.02e-14 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs8114671 0.836 rs734308 chr20:33572096 A/G cg24642439 chr20:33292090 TP53INP2 -0.41 -8.06 -0.3 3.75e-15 Height; BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg14863265 chr7:2801509 GNA12 -0.41 -8.77 -0.33 1.64e-17 Height; BRCA cis rs7618915 0.501 rs3774366 chr3:52641255 T/C cg10802521 chr3:52805072 NEK4 -0.33 -9.08 -0.34 1.3e-18 Bipolar disorder; BRCA cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.16 -0.43 9.45e-31 Electroencephalogram traits; BRCA cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg14061069 chr19:46274453 DMPK -0.49 -12.2 -0.43 6.19e-31 Coronary artery disease; BRCA cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg02187348 chr16:89574699 SPG7 -0.38 -8.05 -0.3 4.1e-15 Multiple myeloma (IgH translocation); BRCA cis rs67478160 0.506 rs6575998 chr14:104250417 A/G cg08213375 chr14:104286397 PPP1R13B 0.57 15.03 0.51 5.86e-44 Schizophrenia; BRCA cis rs769267 0.930 rs3752151 chr19:19616026 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.2 0.34 5.04e-19 Tonsillectomy; BRCA cis rs4563143 0.675 rs56123392 chr19:29255631 A/C cg04546413 chr19:29218101 NA 0.65 12.37 0.44 1.19e-31 Methadone dose in opioid dependence; BRCA cis rs7520050 0.966 rs4660319 chr1:46341623 C/T cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA cis rs34779708 0.733 rs11597184 chr10:35397396 G/A cg03585969 chr10:35415529 CREM 0.55 11.23 0.41 7.79e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17401966 1.000 rs12407992 chr1:10311983 A/C cg15208524 chr1:10270712 KIF1B 0.38 8.44 0.32 2.11e-16 Hepatocellular carcinoma; BRCA cis rs477895 0.713 rs2282490 chr11:63962152 T/C cg04317338 chr11:64019027 PLCB3 0.55 9.46 0.35 5.59e-20 Mean platelet volume; BRCA trans rs853679 0.546 rs36092177 chr6:28357807 C/T cg06606381 chr12:133084897 FBRSL1 -0.9 -8.84 -0.33 9.38e-18 Depression; BRCA trans rs3857536 0.776 rs1002764 chr6:66945760 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 1.99e-14 Blood trace element (Cu levels); BRCA cis rs17601876 0.545 rs17523284 chr15:51538723 G/A cg19946085 chr15:51559439 CYP19A1 -0.31 -8.07 -0.3 3.4e-15 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.65 12.34 0.44 1.51e-31 Gut microbiome composition (summer); BRCA cis rs2688608 0.592 rs3933085 chr10:75483331 C/T cg23231163 chr10:75533350 FUT11 -0.34 -8.89 -0.33 6e-18 Inflammatory bowel disease; BRCA cis rs6840258 1.000 rs56390363 chr4:87943087 G/A cg08197287 chr4:87952173 AFF1 -0.44 -8.56 -0.32 8.47e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs3733585 0.699 rs7435196 chr4:9967556 A/C cg00071950 chr4:10020882 SLC2A9 -0.47 -11.15 -0.4 1.71e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg12927641 chr6:109611667 NA -0.38 -9.85 -0.36 2.11e-21 Reticulocyte fraction of red cells; BRCA cis rs6860806 0.507 rs582490 chr5:131710095 G/A cg07395648 chr5:131743802 NA 0.38 8.26 0.31 8.54e-16 Breast cancer; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg04944784 chr2:26401820 FAM59B 0.99 14.85 0.51 4.4e-43 Gut microbiome composition (summer); BRCA cis rs1057239 0.739 rs1014554 chr1:175133626 A/G cg17845761 chr1:175162550 KIAA0040 0.26 9.92 0.37 1.17e-21 Diastolic blood pressure; BRCA cis rs757110 0.770 rs11024271 chr11:17395540 T/C cg15432903 chr11:17409602 KCNJ11 0.71 15.5 0.52 3.09e-46 Type 2 diabetes; BRCA cis rs6582630 0.555 rs7133706 chr12:38475465 G/A cg26384229 chr12:38710491 ALG10B -0.62 -14.85 -0.51 4.28e-43 Drug-induced liver injury (flucloxacillin); BRCA cis rs6582630 0.555 rs11182193 chr12:38474090 C/G cg13010199 chr12:38710504 ALG10B 0.51 10.69 0.39 1.24e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs9463078 0.764 rs3799971 chr6:44819319 G/C cg25276700 chr6:44698697 NA -0.36 -8.3 -0.31 6.15e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.9 0.36 1.36e-21 Bipolar disorder; BRCA cis rs4820539 0.902 rs737846 chr22:23460669 A/G cg14186256 chr22:23484241 RTDR1 0.76 23.09 0.67 3.08e-86 Bone mineral density; BRCA cis rs9815354 0.812 rs17282671 chr3:41887455 T/C cg03022575 chr3:42003672 ULK4 0.71 9.71 0.36 7.25e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs7945705 0.869 rs2742471 chr11:9003953 C/T cg12365402 chr11:9010492 NRIP3 -0.42 -9.92 -0.37 1.18e-21 Hemoglobin concentration; BRCA cis rs9790314 0.967 rs460165 chr3:161087710 G/A cg03342759 chr3:160939853 NMD3 -0.52 -11.19 -0.4 1.14e-26 Morning vs. evening chronotype; BRCA cis rs7599312 0.534 rs2371615 chr2:213405660 G/T cg16329650 chr2:213403929 ERBB4 0.66 19.56 0.61 4.1e-67 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13053817 1.000 rs12485237 chr22:29837286 A/G cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.51 -9.1 -0.34 1.13e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs738322 0.533 rs2284064 chr22:38547395 A/C cg25457927 chr22:38595422 NA -0.36 -12.9 -0.45 5.4e-34 Cutaneous nevi; BRCA cis rs2439831 0.850 rs7169988 chr15:44060435 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.83 0.42 2.48e-29 Lung cancer in ever smokers; BRCA cis rs6860806 0.507 rs272882 chr5:131669161 G/T cg12564285 chr5:131593104 PDLIM4 0.35 7.98 0.3 6.85e-15 Breast cancer; BRCA cis rs1008375 0.966 rs11733730 chr4:17625209 G/C cg02297831 chr4:17616191 MED28 0.38 9.03 0.34 2.03e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11605924 0.967 rs7121611 chr11:45864142 A/T ch.11.939596F chr11:45881766 CRY2 -0.47 -10.2 -0.37 1.02e-22 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg01448562 chr3:133502909 NA -0.61 -14.46 -0.5 3.17e-41 Iron status biomarkers; BRCA cis rs4900538 0.927 rs1190547 chr14:102905087 G/C cg18135206 chr14:102964638 TECPR2 -1.04 -28.84 -0.75 9.1e-118 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs61931739 0.635 rs1852224 chr12:33963080 A/C cg26384229 chr12:38710491 ALG10B 0.39 8.87 0.33 7e-18 Morning vs. evening chronotype; BRCA cis rs7666738 0.753 rs6826709 chr4:98714553 C/G cg17366294 chr4:99064904 C4orf37 0.43 9.93 0.37 1e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7662987 0.517 rs1311615 chr4:100012261 G/A cg12011299 chr4:100065546 ADH4 0.49 11.02 0.4 5.78e-26 Smoking initiation; BRCA cis rs9815354 0.812 rs55916855 chr3:42002761 A/G cg03022575 chr3:42003672 ULK4 0.73 10.08 0.37 2.94e-22 Pulse pressure;Diastolic blood pressure; BRCA cis rs651907 0.557 rs3094297 chr3:101399260 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 16.33 0.54 2.23e-50 Colorectal cancer; BRCA cis rs3857067 0.806 rs722486 chr4:95092315 G/A cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.45 -0.35 6.42e-20 QT interval; BRCA cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg08873628 chr1:175162347 KIAA0040 0.33 7.89 0.3 1.31e-14 Alcohol dependence; BRCA cis rs7945705 0.935 rs2568062 chr11:8887945 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.79 -0.51 8.68e-43 Hemoglobin concentration; BRCA cis rs35110281 0.641 rs9983670 chr21:45083425 A/G cg21573476 chr21:45109991 RRP1B -0.49 -12.84 -0.45 9.49e-34 Mean corpuscular volume; BRCA trans rs9951602 0.512 rs9953258 chr18:76651199 A/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.01 0.58 5.8e-59 Obesity-related traits; BRCA cis rs12950390 0.853 rs12450729 chr17:45855363 A/G cg03474202 chr17:45855739 NA -0.48 -12.72 -0.45 3.53e-33 IgG glycosylation; BRCA cis rs600806 0.778 rs2039694 chr1:109991700 A/G cg20591472 chr1:110008990 SYPL2 0.33 8.3 0.31 6.14e-16 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.683 rs7305703 chr12:38138381 T/C cg06521331 chr12:34319734 NA -0.53 -10.09 -0.37 2.64e-22 Bladder cancer; BRCA cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.15 -0.34 7.47e-19 Bipolar disorder; BRCA trans rs12310956 0.532 rs7955514 chr12:33978737 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.06 0.49 2.68e-39 Morning vs. evening chronotype; BRCA trans rs7615952 0.673 rs7632557 chr3:125634881 G/C cg07211511 chr3:129823064 LOC729375 -1.05 -18.39 -0.59 5.85e-61 Blood pressure (smoking interaction); BRCA cis rs34779708 0.931 rs4934721 chr10:35377715 A/G cg03585969 chr10:35415529 CREM 0.55 11.47 0.41 7.99e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.74 -0.33 2.07e-17 Total body bone mineral density; BRCA cis rs3806843 0.900 rs2531341 chr5:140130894 C/T cg11822812 chr5:140052017 DND1 -0.32 -8.69 -0.33 3.01e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs17384381 0.859 rs12724823 chr1:85906385 G/T cg16011679 chr1:85725395 C1orf52 0.51 7.84 0.3 1.95e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7267979 1.000 rs404394 chr20:25447896 A/G cg08601574 chr20:25228251 PYGB 0.34 8.17 0.31 1.65e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg21138405 chr5:131827807 IRF1 -0.4 -13.38 -0.47 3.51e-36 Asthma (sex interaction); BRCA cis rs10771431 0.935 rs1117735 chr12:9372728 G/A cg08997352 chr12:9597637 DDX12 -0.49 -9.65 -0.36 1.19e-20 Breast size; BRCA cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg23262073 chr20:60523788 NA 0.55 13.61 0.47 3.28e-37 Obesity-related traits; BRCA cis rs7020830 0.898 rs308523 chr9:37338785 C/T cg14294708 chr9:37120828 ZCCHC7 1.03 29.32 0.76 2.17e-120 Schizophrenia; BRCA cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg18876405 chr7:65276391 NA 0.62 15.48 0.52 3.92e-46 Aortic root size; BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.61 0.61 2.24e-67 Platelet count; BRCA cis rs2180341 0.960 rs7745944 chr6:127709574 A/G cg24812749 chr6:127587940 RNF146 0.86 19.72 0.62 5.43e-68 Breast cancer; BRCA trans rs11098499 0.874 rs6851169 chr4:120117510 T/C cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.8e-24 Corneal astigmatism; BRCA trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg15934090 chr1:100435551 SLC35A3 0.36 8.32 0.31 5.13e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg23711669 chr6:146136114 FBXO30 -0.78 -18.09 -0.58 2.33e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs7833790 0.963 rs28823280 chr8:82777716 G/A cg17211192 chr8:82754475 SNX16 0.59 11.63 0.42 1.73e-28 Diastolic blood pressure; BRCA trans rs6479891 1.000 rs61853635 chr10:65276510 T/G cg14819942 chr15:35414228 NA 0.36 8.72 0.33 2.33e-17 Arthritis (juvenile idiopathic); BRCA cis rs4911259 0.552 rs6057663 chr20:31463071 G/T cg13636640 chr20:31349939 DNMT3B -0.45 -11.89 -0.43 1.36e-29 Inflammatory bowel disease; BRCA cis rs9287719 0.967 rs12467642 chr2:10761484 G/A cg02196655 chr2:10830764 NOL10 -0.3 -7.87 -0.3 1.52e-14 Prostate cancer; BRCA cis rs6977660 0.619 rs10231972 chr7:19789354 C/G cg07541023 chr7:19748670 TWISTNB 0.46 8.62 0.32 5.34e-17 Thyroid stimulating hormone; BRCA cis rs17601876 0.843 rs12901187 chr15:51549537 G/A cg19946085 chr15:51559439 CYP19A1 -0.35 -9.5 -0.35 4.11e-20 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1008375 1.000 rs4235388 chr4:17682030 G/A cg04450456 chr4:17643702 FAM184B 0.37 11.03 0.4 5.08e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6964587 0.967 rs4626516 chr7:91807153 G/C cg01689657 chr7:91764605 CYP51A1 0.25 8.92 0.33 4.78e-18 Breast cancer; BRCA cis rs4409675 0.576 rs2078328 chr1:28224976 A/G cg23691781 chr1:28212827 C1orf38 0.33 10.95 0.4 1.11e-25 Corneal astigmatism; BRCA trans rs2262909 0.962 rs409439 chr19:22227432 C/T cg17074339 chr11:11642133 GALNTL4 -0.43 -8.4 -0.32 3e-16 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs921968 0.541 rs490483 chr2:219429052 A/T cg02176678 chr2:219576539 TTLL4 0.46 12.2 0.43 6.39e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.7 0.57 2.51e-57 Platelet count; BRCA cis rs826838 0.834 rs826874 chr12:39122599 C/A cg13010199 chr12:38710504 ALG10B -0.41 -9.78 -0.36 3.9e-21 Heart rate; BRCA cis rs4363385 0.693 rs490553 chr1:153033277 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.34 -0.31 4.7e-16 Inflammatory skin disease; BRCA cis rs35110281 0.633 rs4819292 chr21:45125223 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -11.18 -0.4 1.27e-26 Mean corpuscular volume; BRCA cis rs9341808 0.935 rs9343974 chr6:80924645 A/G cg08355045 chr6:80787529 NA 0.33 8.23 0.31 1.03e-15 Sitting height ratio; BRCA cis rs7945718 0.934 rs10831909 chr11:12817182 C/G cg25843174 chr11:12811716 TEAD1 0.25 9.36 0.35 1.31e-19 Educational attainment (years of education); BRCA cis rs933688 1.000 rs60513756 chr5:90727692 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.91 20.12 0.62 4.1e-70 Smoking behavior; BRCA cis rs6500602 0.893 rs8061742 chr16:4489436 T/C cg08645402 chr16:4508243 NA 0.35 7.89 0.3 1.34e-14 Schizophrenia; BRCA cis rs8072100 0.875 rs4794047 chr17:45763005 A/T cg08085267 chr17:45401833 C17orf57 0.65 14.51 0.5 1.94e-41 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4665809 0.531 rs12987980 chr2:26462093 A/T cg27170947 chr2:26402098 FAM59B 0.97 17.16 0.56 1.38e-54 Gut microbiome composition (summer); BRCA trans rs7824557 0.628 rs11782706 chr8:11186215 A/C cg06636001 chr8:8085503 FLJ10661 0.43 8.45 0.32 1.97e-16 Retinal vascular caliber; BRCA cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.19 0.46 2.76e-35 Electroencephalogram traits; BRCA cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg17366294 chr4:99064904 C4orf37 0.41 9.49 0.35 4.41e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs9394841 0.667 rs71558769 chr6:41782107 T/C cg08135965 chr6:41755394 TOMM6 0.5 8.22 0.31 1.09e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs4819052 0.851 rs8133045 chr21:46658137 A/G cg06618935 chr21:46677482 NA -0.37 -8.03 -0.3 4.75e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9325144 0.505 rs901635 chr12:38646572 A/C cg26384229 chr12:38710491 ALG10B -0.67 -16.7 -0.55 3.07e-52 Morning vs. evening chronotype; BRCA cis rs300703 0.542 rs189762 chr2:180079 A/T cg21211680 chr2:198530 NA -0.38 -8.26 -0.31 8.23e-16 Blood protein levels; BRCA cis rs7772486 0.686 rs2092263 chr6:146029687 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -16.94 -0.56 2e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs6912958 0.712 rs9444525 chr6:88324142 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -8.63 -0.32 4.92e-17 Monocyte percentage of white cells; BRCA cis rs600231 0.598 rs2508712 chr11:65232261 C/G cg01292856 chr11:65242576 NA 0.32 8.09 0.3 2.99e-15 Bone mineral density; BRCA cis rs3096299 0.632 rs8051537 chr16:89544384 T/A cg06640241 chr16:89574553 SPG7 0.81 19.88 0.62 8.28e-69 Multiple myeloma (IgH translocation); BRCA cis rs4563143 0.675 rs73025085 chr19:29247018 C/A cg04546413 chr19:29218101 NA 0.64 12.33 0.44 1.75e-31 Methadone dose in opioid dependence; BRCA cis rs1005277 0.579 rs2749616 chr10:38510993 A/T cg25427524 chr10:38739819 LOC399744 -0.73 -17.57 -0.57 1.1e-56 Extrinsic epigenetic age acceleration; BRCA cis rs7149337 0.869 rs7159770 chr14:51691835 G/A cg23942311 chr14:51606299 NA 0.4 11.05 0.4 4.11e-26 Cancer; BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs736408 0.608 rs6445534 chr3:52743384 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -11.87 -0.42 1.69e-29 Bipolar disorder; BRCA cis rs1011018 0.628 rs73158613 chr7:139435454 G/A cg03224163 chr7:139420300 HIPK2 -0.54 -9.23 -0.34 3.9e-19 Systolic blood pressure; BRCA cis rs7523273 1.000 rs1142469 chr1:207965427 G/A cg22525895 chr1:207977042 MIR29B2 -0.5 -11.93 -0.43 9.51e-30 Schizophrenia; BRCA trans rs11722228 0.522 rs73212808 chr4:10055439 G/C cg26043149 chr18:55253948 FECH 1.07 23.48 0.68 2.18e-88 Gout;Urate levels;Serum uric acid levels; BRCA cis rs7020830 0.898 rs308495 chr9:37277603 G/T cg14294708 chr9:37120828 ZCCHC7 1.04 30.85 0.77 1.21e-128 Schizophrenia; BRCA cis rs11098499 0.863 rs10034450 chr4:120455649 A/G cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs1865760 0.613 rs9379805 chr6:25938764 T/A cg12310025 chr6:25882481 NA -0.38 -8.72 -0.33 2.44e-17 Height; BRCA cis rs514406 0.644 rs6662414 chr1:53198893 A/G cg24675658 chr1:53192096 ZYG11B 0.66 15.54 0.52 1.95e-46 Monocyte count; BRCA cis rs1975991 0.765 rs7637952 chr3:187948630 T/G cg15417654 chr3:187959138 LPP 0.33 8.37 0.31 3.58e-16 White matter integrity (bipolar disorder risk interaction); BRCA cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg02574844 chr11:5959923 NA -0.38 -8.27 -0.31 7.71e-16 DNA methylation (variation); BRCA cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA trans rs2204008 0.713 rs12366709 chr12:38210179 G/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs938554 0.612 rs28592748 chr4:9998605 T/C cg00071950 chr4:10020882 SLC2A9 0.41 7.87 0.3 1.5e-14 Blood metabolite levels; BRCA cis rs9942416 0.660 rs2307113 chr5:74998264 C/T cg19683494 chr5:74908142 NA 0.48 9.02 0.34 2.18e-18 Age-related disease endophenotypes; BRCA cis rs9503598 0.778 rs10155771 chr6:3465930 G/A cg00476032 chr6:3446245 SLC22A23 0.43 10.6 0.39 2.83e-24 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs10465746 0.725 rs10127737 chr1:84368642 G/A cg10977910 chr1:84465055 TTLL7 0.59 12.66 0.45 6.17e-33 Obesity-related traits; BRCA cis rs11098499 0.954 rs17006190 chr4:120418838 C/G cg09307838 chr4:120376055 NA 0.72 15.17 0.51 1.29e-44 Corneal astigmatism; BRCA cis rs992157 0.560 rs10932763 chr2:219085863 G/C cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.26 -0.34 3.04e-19 Colorectal cancer; BRCA cis rs7917772 0.582 rs4919665 chr10:104366042 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.49 -14.82 -0.51 6.55e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1215050 0.791 rs6838628 chr4:98809574 A/G cg05340658 chr4:99064831 C4orf37 0.44 10.18 0.37 1.12e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 12.67 0.45 5.35e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1005277 0.589 rs2749624 chr10:38529865 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.58e-15 Extrinsic epigenetic age acceleration; BRCA cis rs11955398 0.501 rs10057004 chr5:60041034 G/C cg02684056 chr5:59996105 DEPDC1B -0.36 -8.3 -0.31 6.24e-16 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.43 -0.32 2.28e-16 Total body bone mineral density; BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg18765753 chr7:1198926 ZFAND2A -0.47 -11.6 -0.42 2.38e-28 Longevity;Endometriosis; BRCA cis rs6570726 0.791 rs435671 chr6:145881215 A/G cg23711669 chr6:146136114 FBXO30 0.78 18.79 0.6 4.89e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 1.000 rs4808951 chr19:19550306 C/G cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs10782582 0.593 rs12130832 chr1:76234294 T/C cg10523679 chr1:76189770 ACADM -0.44 -8.38 -0.31 3.34e-16 Daytime sleep phenotypes; BRCA cis rs561341 1.000 rs2470243 chr17:30290955 C/T cg00745463 chr17:30367425 LRRC37B -0.6 -9.77 -0.36 4.04e-21 Hip circumference adjusted for BMI; BRCA cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg22105103 chr4:187893119 NA -0.41 -13.25 -0.46 1.35e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs72781680 0.898 rs72781639 chr2:24204148 C/G cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs250677 0.687 rs250666 chr5:148454622 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -9.02 -0.34 2.18e-18 Breast cancer; BRCA cis rs6912958 0.874 rs2103764 chr6:88157392 T/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -9.02 -0.34 2.12e-18 Monocyte percentage of white cells; BRCA cis rs79839061 0.610 rs3775130 chr4:875144 G/A cg23992470 chr4:843637 GAK 0.56 8.27 0.31 8.04e-16 Intelligence (multi-trait analysis); BRCA cis rs1994135 0.630 rs11052760 chr12:33724949 A/T cg06521331 chr12:34319734 NA -0.53 -9.28 -0.34 2.62e-19 Resting heart rate; BRCA trans rs11098499 0.826 rs12511640 chr4:120251248 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg08470875 chr2:26401718 FAM59B -0.64 -9.54 -0.35 2.95e-20 Gut microbiome composition (summer); BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg21226059 chr5:178986404 RUFY1 0.53 15.07 0.51 3.8e-44 Lung cancer; BRCA cis rs881375 0.867 rs6478487 chr9:123672777 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.49 0.32 1.44e-16 Rheumatoid arthritis; BRCA cis rs1165205 0.500 rs629835 chr6:25879330 T/C cg03264133 chr6:25882463 NA -0.82 -19.86 -0.62 9.97e-69 Urate levels; BRCA cis rs4851313 0.527 rs10183150 chr2:100939117 A/G cg14675211 chr2:100938903 LONRF2 0.43 9.94 0.37 9.9e-22 Intelligence (multi-trait analysis); BRCA cis rs698833 0.729 rs4952708 chr2:44517072 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.58 0.35 2.19e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs832540 0.966 rs33321 chr5:56206073 G/T cg24531977 chr5:56204891 C5orf35 -0.42 -8.55 -0.32 9.39e-17 Coronary artery disease; BRCA cis rs425277 1.000 rs809912 chr1:2078385 C/T cg24578937 chr1:2090814 PRKCZ 0.57 17.81 0.58 6.82e-58 Height; BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg13047869 chr3:10149882 C3orf24 0.58 12.07 0.43 2.41e-30 Alzheimer's disease; BRCA cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg12310025 chr6:25882481 NA -0.79 -18.67 -0.59 2.09e-62 Intelligence (multi-trait analysis); BRCA cis rs1538970 0.962 rs9429075 chr1:45818421 G/A cg05343316 chr1:45956843 TESK2 0.55 10.93 0.4 1.31e-25 Platelet count; BRCA cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.78 12.63 0.45 8.73e-33 Mean platelet volume; BRCA cis rs4481887 1.000 rs4916124 chr1:248466495 T/C cg13385794 chr1:248469461 NA 0.28 7.81 0.3 2.28e-14 Common traits (Other); BRCA cis rs208520 0.690 rs12201219 chr6:66748862 A/T cg07460842 chr6:66804631 NA 0.99 19.93 0.62 4.01e-69 Exhaled nitric oxide output; BRCA trans rs2665103 0.655 rs1501367 chr15:82522816 A/G cg04831495 chr15:85060580 GOLGA6L5 -0.33 -8.97 -0.33 3.15e-18 Intelligence (multi-trait analysis); BRCA cis rs7615952 0.641 rs7618515 chr3:125790578 C/T cg15145296 chr3:125709740 NA -0.56 -8.89 -0.33 5.97e-18 Blood pressure (smoking interaction); BRCA cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg04546413 chr19:29218101 NA 0.66 13.26 0.46 1.32e-35 Methadone dose in opioid dependence; BRCA cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.21 -0.31 1.2e-15 Bipolar disorder; BRCA cis rs10504073 0.669 rs341809 chr8:50042557 C/T cg00325661 chr8:49890786 NA 0.38 10.83 0.39 3.22e-25 Blood metabolite ratios; BRCA cis rs8177253 0.761 rs35332919 chr3:133519002 T/A cg01448562 chr3:133502909 NA -0.76 -19.22 -0.61 2.55e-65 Iron status biomarkers; BRCA cis rs561341 1.000 rs561341 chr17:30316385 T/G cg12193833 chr17:30244370 NA -0.55 -8.77 -0.33 1.62e-17 Hip circumference adjusted for BMI; BRCA cis rs9649213 0.593 rs12728 chr7:97922851 C/T cg21770322 chr7:97807741 LMTK2 0.45 12.0 0.43 4.73e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs6748734 0.817 rs4465762 chr2:241798862 G/A cg04034577 chr2:241836375 C2orf54 -0.5 -12.55 -0.44 1.95e-32 Urinary metabolites; BRCA cis rs9463078 0.804 rs9395086 chr6:45225331 T/A cg25276700 chr6:44698697 NA -0.35 -7.95 -0.3 8.75e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6831352 0.918 rs2602891 chr4:100043284 C/T cg13256891 chr4:100009986 ADH5 0.52 9.67 0.36 9.98e-21 Alcohol dependence; BRCA cis rs9291683 0.525 rs12506455 chr4:10031569 T/A cg11266682 chr4:10021025 SLC2A9 0.49 12.91 0.45 4.67e-34 Bone mineral density; BRCA cis rs523522 0.923 rs1048830 chr12:120882217 G/T cg27279351 chr12:120934652 DYNLL1 0.51 11.98 0.43 5.8e-30 High light scatter reticulocyte count; BRCA cis rs10751667 0.600 rs7395387 chr11:1008664 G/C ch.11.42038R chr11:967971 AP2A2 0.47 14.28 0.49 2.43e-40 Alzheimer's disease (late onset); BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg08470875 chr2:26401718 FAM59B -0.51 -8.21 -0.31 1.21e-15 Gut microbiome composition (summer); BRCA cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg00108164 chr2:264199 ACP1;SH3YL1 -0.56 -11.18 -0.4 1.25e-26 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 15.63 0.53 7.54e-47 Smoking behavior; BRCA cis rs765787 0.530 rs11636410 chr15:45535913 A/C cg24006582 chr15:45444508 DUOX1 0.51 10.21 0.37 9.21e-23 Uric acid levels; BRCA cis rs2764980 1.000 rs2764978 chr10:3283385 C/G cg11630169 chr10:3283847 NA -0.4 -9.23 -0.34 3.82e-19 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs1008375 0.966 rs6449313 chr4:17588320 A/G cg15017067 chr4:17643749 FAM184B 0.34 10.41 0.38 1.57e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2762353 0.935 rs1359232 chr6:25809716 C/A cg03264133 chr6:25882463 NA 0.48 10.86 0.39 2.49e-25 Blood metabolite levels; BRCA cis rs3862260 0.509 rs3795663 chr1:120165187 G/A cg16322792 chr1:120165303 ZNF697 0.58 15.43 0.52 6.54e-46 Systemic lupus erythematosus; BRCA cis rs34172651 0.502 rs12930727 chr16:24838497 G/T cg00339695 chr16:24857497 SLC5A11 -0.37 -9.42 -0.35 8.11e-20 Intelligence (multi-trait analysis); BRCA cis rs7092929 0.941 rs611726 chr10:3572073 T/C cg14308648 chr10:3568949 NA 0.45 8.04 0.3 4.42e-15 Coronary artery calcification; BRCA cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg02153584 chr22:29168773 CCDC117 0.54 11.43 0.41 1.13e-27 Lymphocyte counts; BRCA cis rs796364 0.760 rs2881594 chr2:201026183 T/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -9.06 -0.34 1.57e-18 Schizophrenia; BRCA cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg11644478 chr21:40555479 PSMG1 0.59 8.76 0.33 1.73e-17 Cognitive function; BRCA cis rs72781680 0.821 rs2176265 chr2:24158638 C/G cg08917208 chr2:24149416 ATAD2B 0.63 10.57 0.39 3.64e-24 Lymphocyte counts; BRCA cis rs8072100 0.967 rs8078880 chr17:45676526 G/C cg08085267 chr17:45401833 C17orf57 0.58 12.19 0.43 7.29e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs12142240 0.698 rs45517837 chr1:46859225 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs10504229 0.683 rs7459925 chr8:58111771 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -9.0 -0.34 2.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs10899021 1.000 rs11236202 chr11:74376692 A/G cg25880958 chr11:74394337 NA -0.72 -9.39 -0.35 1.03e-19 Response to metformin (IC50); BRCA cis rs68170813 0.559 rs1121312 chr7:106927820 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.52 -0.32 1.14e-16 Coronary artery disease; BRCA cis rs4665809 0.590 rs62128457 chr2:26467347 C/A cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA trans rs208520 0.955 rs12204033 chr6:67001525 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.81 13.36 0.47 4.29e-36 Exhaled nitric oxide output; BRCA cis rs172166 0.694 rs203893 chr6:28062066 C/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.37 0.31 3.7e-16 Cardiac Troponin-T levels; BRCA cis rs13315871 0.929 rs9818581 chr3:58293101 A/G cg20936604 chr3:58311152 NA -0.66 -8.47 -0.32 1.65e-16 Cholesterol, total; BRCA cis rs60871478 1.000 rs62432242 chr7:797715 G/A cg05535760 chr7:792225 HEATR2 0.71 13.0 0.46 1.92e-34 Cerebrospinal P-tau181p levels; BRCA cis rs6735179 0.607 rs10185594 chr2:1746661 G/A cg10160682 chr2:1713001 PXDN -0.37 -7.9 -0.3 1.26e-14 Response to antipsychotic treatment; BRCA cis rs4862750 1.000 rs4862751 chr4:187904050 G/A cg10295955 chr4:187884368 NA -0.9 -26.24 -0.72 1.48e-103 Lobe attachment (rater-scored or self-reported); BRCA cis rs6788895 1.000 rs41372346 chr3:150489116 C/G cg09723797 chr3:150481914 SIAH2 0.7 8.47 0.32 1.67e-16 Breast cancer; BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg20203395 chr5:56204925 C5orf35 -0.47 -9.79 -0.36 3.62e-21 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs35740288 0.520 rs56183577 chr15:86319706 A/G cg20737812 chr15:86336631 KLHL25 -0.39 -8.49 -0.32 1.42e-16 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.35 -9.84 -0.36 2.27e-21 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.587 rs3208733 chr6:26414425 C/T cg09904177 chr6:26538194 HMGN4 -0.37 -9.75 -0.36 4.82e-21 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg12311346 chr5:56204834 C5orf35 -0.81 -16.73 -0.55 2.22e-52 Initial pursuit acceleration; BRCA cis rs832540 0.552 rs702681 chr5:56218029 C/T cg24531977 chr5:56204891 C5orf35 -0.5 -10.41 -0.38 1.56e-23 Coronary artery disease; BRCA cis rs4595586 0.525 rs7968566 chr12:39377200 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs4742903 0.935 rs10820602 chr9:106861282 C/T cg21169611 chr9:106856078 SMC2 0.35 9.25 0.34 3.19e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7246657 0.943 rs10415937 chr19:37830064 T/G cg14683738 chr19:37701593 ZNF585B 0.45 7.98 0.3 6.65e-15 Coronary artery calcification; BRCA cis rs12971120 0.891 rs12968731 chr18:72169708 G/T cg26446133 chr18:72167187 CNDP2 -0.76 -14.55 -0.5 1.18e-41 Refractive error; BRCA cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg20503657 chr10:835505 NA 1.05 18.42 0.59 4.21e-61 Eosinophil percentage of granulocytes; BRCA cis rs2836974 0.533 rs4817999 chr21:40554355 C/A cg17971929 chr21:40555470 PSMG1 -0.63 -14.91 -0.51 2.36e-43 Cognitive function; BRCA cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg02018176 chr4:1364513 KIAA1530 0.37 7.93 0.3 9.81e-15 Longevity; BRCA cis rs7520050 0.831 rs61783170 chr1:46256329 T/C cg24296786 chr1:45957014 TESK2 0.45 9.92 0.37 1.17e-21 Red blood cell count;Reticulocyte count; BRCA trans rs11764590 0.715 rs62444907 chr7:2083267 C/T cg11693508 chr17:37793320 STARD3 0.53 9.18 0.34 5.95e-19 Neuroticism; BRCA cis rs7267979 0.966 rs2227890 chr20:25260931 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.13e-21 Liver enzyme levels (alkaline phosphatase); BRCA trans rs62103177 0.525 rs10438902 chr18:77745640 A/G cg05926928 chr17:57297772 GDPD1 -0.58 -8.83 -0.33 1e-17 Opioid sensitivity; BRCA cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg10802521 chr3:52805072 NEK4 -0.3 -7.99 -0.3 6.35e-15 Electroencephalogram traits; BRCA cis rs4363385 0.655 rs11205163 chr1:152983677 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.36 -0.35 1.29e-19 Inflammatory skin disease; BRCA cis rs6484504 0.532 rs11031330 chr11:31275073 G/A cg06552810 chr11:31128660 NA -0.38 -8.76 -0.33 1.71e-17 Red blood cell count; BRCA cis rs61990749 0.597 rs1477260 chr14:78256818 G/C cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.11 0.37 2.09e-22 Fibroblast growth factor basic levels; BRCA cis rs6121246 0.559 rs6060944 chr20:30372114 G/A cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs8077889 0.869 rs11713 chr17:41845824 A/G cg26893861 chr17:41843967 DUSP3 -0.57 -11.67 -0.42 1.16e-28 Triglycerides; BRCA cis rs3858526 0.959 rs61876224 chr11:5952859 G/A cg05234568 chr11:5960015 NA -0.51 -9.98 -0.37 6.72e-22 DNA methylation (variation); BRCA cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs2075371 0.933 rs1421481 chr7:133964380 A/C cg11752832 chr7:134001865 SLC35B4 0.52 13.17 0.46 3.21e-35 Mean platelet volume; BRCA cis rs736408 0.812 rs2071508 chr3:52826846 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.33 -10.29 -0.38 4.52e-23 Bipolar disorder; BRCA cis rs514406 0.793 rs4500255 chr1:53213279 A/G cg25767906 chr1:53392781 SCP2 0.38 8.7 0.33 2.86e-17 Monocyte count; BRCA cis rs4233802 1.000 rs4425094 chr2:151139891 C/T cg25300694 chr2:151184358 NA 0.76 8.13 0.31 2.29e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs2243480 1.000 rs1796220 chr7:66062100 C/T cg18252515 chr7:66147081 NA -1.04 -15.52 -0.52 2.55e-46 Diabetic kidney disease; BRCA cis rs4363385 0.747 rs1413849 chr1:152970233 C/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.72 -0.33 2.44e-17 Inflammatory skin disease; BRCA cis rs2835872 0.758 rs1787394 chr21:39036176 C/A cg06728970 chr21:39037746 KCNJ6 0.45 12.88 0.45 6.44e-34 Electroencephalographic traits in alcoholism; BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.2 -0.43 6.44e-31 Alzheimer's disease; BRCA cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.49 -0.47 1.15e-36 Developmental language disorder (linguistic errors); BRCA cis rs365132 0.715 rs181330 chr5:176404962 A/G cg16309518 chr5:176445507 NA -0.4 -9.8 -0.36 3.14e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs11105298 0.891 rs10858902 chr12:89927789 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.28 -0.34 2.56e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg14847009 chr1:175162515 KIAA0040 -0.25 -9.43 -0.35 7.54e-20 Alcohol dependence; BRCA cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.24 0.34 3.68e-19 Systemic lupus erythematosus; BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg27170947 chr2:26402098 FAM59B 0.97 16.95 0.56 1.71e-53 Gut microbiome composition (summer); BRCA cis rs9814567 1.000 rs13090969 chr3:134307257 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.63 0.32 4.73e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9341808 0.718 rs3805920 chr6:80892745 T/C cg08355045 chr6:80787529 NA 0.39 9.92 0.37 1.09e-21 Sitting height ratio; BRCA cis rs1801251 0.929 rs12694917 chr2:233707611 C/T cg25237894 chr2:233734115 C2orf82 -0.41 -11.91 -0.43 1.1e-29 Coronary artery disease; BRCA cis rs780094 0.544 rs780108 chr2:27684957 T/C cg22903471 chr2:27725779 GCKR -0.35 -8.36 -0.31 3.85e-16 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs2243480 0.908 rs2460431 chr7:65622846 A/G cg18252515 chr7:66147081 NA 1.03 15.25 0.52 5.04e-45 Diabetic kidney disease; BRCA cis rs4713118 0.824 rs2092075 chr6:27749330 G/C cg20933634 chr6:27740509 NA 0.49 9.82 0.36 2.62e-21 Parkinson's disease; BRCA cis rs7246657 0.722 rs968073 chr19:38192021 G/A cg14683738 chr19:37701593 ZNF585B -0.47 -8.04 -0.3 4.5e-15 Coronary artery calcification; BRCA cis rs62064224 0.589 rs2344976 chr17:30685935 T/C cg25809561 chr17:30822961 MYO1D 0.37 8.85 0.33 8.29e-18 Schizophrenia; BRCA cis rs4285028 0.747 rs4048703 chr3:121374361 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.83 -15.96 -0.53 1.71e-48 Multiple sclerosis; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 0.8 12.9 0.45 5.53e-34 Platelet count; BRCA cis rs4363385 0.740 rs1338181 chr1:153010301 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.05e-17 Inflammatory skin disease; BRCA cis rs72928364 1.000 rs62275199 chr3:100695413 A/G cg10123952 chr3:100791384 NA 0.53 7.85 0.3 1.71e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs6087990 0.871 rs4911252 chr20:31330115 A/G cg13636640 chr20:31349939 DNMT3B -0.7 -20.72 -0.63 2.45e-73 Ulcerative colitis; BRCA cis rs7520050 0.933 rs6661163 chr1:46255004 A/G cg24296786 chr1:45957014 TESK2 0.44 9.59 0.35 1.95e-20 Red blood cell count;Reticulocyte count; BRCA cis rs6121246 0.559 rs6060922 chr20:30333909 C/T cg13852791 chr20:30311386 BCL2L1 0.96 23.39 0.68 6.61e-88 Mean corpuscular hemoglobin; BRCA cis rs2505998 1.000 rs2506006 chr10:43581501 A/G cg15436174 chr10:43711423 RASGEF1A -0.4 -7.97 -0.3 7.06e-15 Hirschsprung disease; BRCA cis rs897080 0.515 rs1067332 chr2:44626972 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.55 10.49 0.38 7.55e-24 Height; BRCA cis rs11123170 0.542 rs28522253 chr2:113967387 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.52 8.03 0.3 4.54e-15 Renal function-related traits (BUN); BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg23285459 chr7:2802560 GNA12 -0.37 -9.23 -0.34 3.92e-19 Height; BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.64 -13.64 -0.47 2.37e-37 Lymphocyte counts; BRCA cis rs6728642 0.708 rs115507803 chr2:97752054 T/C cg26665480 chr2:98280029 ACTR1B -0.67 -8.09 -0.3 2.96e-15 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs17209837 0.607 rs60040620 chr7:87085379 C/A cg00919237 chr7:87102261 ABCB4 -0.53 -10.22 -0.37 8.29e-23 Gallbladder cancer; BRCA cis rs10782582 0.609 rs12138898 chr1:76375183 G/T cg03433033 chr1:76189801 ACADM -0.39 -8.04 -0.3 4.28e-15 Daytime sleep phenotypes; BRCA cis rs7917772 0.582 rs7922780 chr10:104401203 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -10.18 -0.37 1.18e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs72781680 1.000 rs72796339 chr2:24143063 T/C cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.42e-39 Lymphocyte counts; BRCA cis rs875971 0.660 rs7807930 chr7:66087165 C/T cg11764359 chr7:65958608 NA -0.67 -14.98 -0.51 1.09e-43 Aortic root size; BRCA cis rs561341 0.882 rs2428337 chr17:30299467 C/T cg12193833 chr17:30244370 NA -0.55 -8.68 -0.32 3.16e-17 Hip circumference adjusted for BMI; BRCA cis rs4665809 1.000 rs1030730 chr2:26284143 T/C cg08470875 chr2:26401718 FAM59B -0.64 -9.54 -0.35 2.95e-20 Gut microbiome composition (summer); BRCA cis rs72781680 0.898 rs10490752 chr2:24025132 C/T cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg08048268 chr3:133502702 NA -0.43 -10.74 -0.39 7.2e-25 Iron status biomarkers; BRCA cis rs1011018 0.628 rs1015121 chr7:139455384 T/C cg03224163 chr7:139420300 HIPK2 -0.59 -8.86 -0.33 7.62e-18 Systolic blood pressure; BRCA cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg18230493 chr5:56204884 C5orf35 0.57 12.3 0.44 2.36e-31 Initial pursuit acceleration; BRCA cis rs13108904 0.901 rs1316393 chr4:1315619 A/G cg00684032 chr4:1343700 KIAA1530 -0.41 -10.13 -0.37 1.85e-22 Obesity-related traits; BRCA cis rs208520 0.690 rs1776365 chr6:66834474 G/T cg07460842 chr6:66804631 NA -1.02 -19.99 -0.62 1.91e-69 Exhaled nitric oxide output; BRCA cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg03808351 chr9:123631620 PHF19 0.61 12.83 0.45 1.05e-33 Birth weight; BRCA cis rs6088580 0.634 rs6120650 chr20:33039973 G/A cg24642439 chr20:33292090 TP53INP2 0.54 11.62 0.42 1.88e-28 Glomerular filtration rate (creatinine); BRCA cis rs3733585 0.534 rs7375642 chr4:9955236 A/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.38 -0.38 1.89e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13315871 1.000 rs13060489 chr3:58339287 G/A cg20936604 chr3:58311152 NA -0.64 -7.81 -0.3 2.27e-14 Cholesterol, total; BRCA cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg20476274 chr7:133979776 SLC35B4 0.62 17.75 0.57 1.35e-57 Mean platelet volume; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.16 0.58 9.71e-60 Platelet count; BRCA cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.44e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7903847 0.596 rs869967 chr10:99147975 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.49 -0.32 1.44e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs11190604 1.000 rs2489037 chr10:102319918 A/G cg07080220 chr10:102295463 HIF1AN -0.61 -13.74 -0.48 7.59e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2832077 0.527 rs9980449 chr21:30224889 G/C cg08807101 chr21:30365312 RNF160 -0.55 -12.39 -0.44 9.28e-32 Cognitive test performance; BRCA cis rs4319547 1.000 rs7307735 chr12:123087442 A/G cg23029597 chr12:123009494 RSRC2 -0.59 -12.28 -0.44 2.98e-31 Body mass index; BRCA cis rs897984 0.542 rs6565217 chr16:31083324 C/T cg02466173 chr16:30829666 NA -0.43 -9.74 -0.36 5.28e-21 Dementia with Lewy bodies; BRCA cis rs12530845 0.943 rs55889179 chr7:135331631 C/T cg23117316 chr7:135346802 PL-5283 -0.37 -8.79 -0.33 1.36e-17 Red blood cell traits; BRCA cis rs870825 0.929 rs72689258 chr4:185590550 G/C cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs1595825 0.945 rs1850634 chr2:198827896 T/C cg19156104 chr2:198669113 PLCL1 -0.44 -8.13 -0.31 2.26e-15 Ulcerative colitis; BRCA cis rs910316 1.000 rs175442 chr14:75603564 T/C cg11812906 chr14:75593930 NEK9 -0.62 -14.2 -0.49 5.61e-40 Height; BRCA cis rs2836974 0.897 rs2026267 chr21:40711477 C/A cg17971929 chr21:40555470 PSMG1 0.73 16.33 0.54 2.45e-50 Cognitive function; BRCA cis rs7903847 0.646 rs10882924 chr10:99159304 T/A cg20016023 chr10:99160130 RRP12 -0.26 -8.43 -0.32 2.23e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg04455712 chr21:45112962 RRP1B 0.42 11.13 0.4 1.99e-26 Mean corpuscular volume; BRCA cis rs72781680 1.000 rs72798417 chr2:24188656 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.2 0.34 5.02e-19 Lymphocyte counts; BRCA cis rs6088580 0.601 rs6059827 chr20:33016358 C/T cg08999081 chr20:33150536 PIGU 0.44 12.2 0.43 6.33e-31 Glomerular filtration rate (creatinine); BRCA cis rs36051895 0.593 rs12340379 chr9:5176352 C/T cg02405213 chr9:5042618 JAK2 -0.46 -8.87 -0.33 7.36e-18 Pediatric autoimmune diseases; BRCA cis rs7666738 0.753 rs34164013 chr4:98976333 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7586879 0.964 rs4077680 chr2:25122942 A/G cg01884057 chr2:25150051 NA 0.34 8.49 0.32 1.4e-16 Body mass index; BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg22800045 chr5:56110881 MAP3K1 0.62 11.98 0.43 5.7e-30 Initial pursuit acceleration; BRCA cis rs425277 0.606 rs262664 chr1:2083537 G/C cg19257562 chr1:2043853 PRKCZ -0.34 -9.0 -0.34 2.54e-18 Height; BRCA cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg11764359 chr7:65958608 NA -0.79 -19.09 -0.6 1.26e-64 Aortic root size; BRCA trans rs826838 0.678 rs11182781 chr12:38610178 C/T cg06521331 chr12:34319734 NA -0.5 -9.09 -0.34 1.26e-18 Heart rate; BRCA cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg04511125 chr2:88470314 THNSL2 0.95 13.73 0.48 8.71e-38 Plasma clusterin levels; BRCA cis rs6594713 0.717 rs9326891 chr5:112873928 C/T cg12552261 chr5:112820674 MCC 0.52 8.57 0.32 7.9e-17 Brain cytoarchitecture; BRCA cis rs9788682 0.642 rs2568483 chr15:78752343 A/G cg24631222 chr15:78858424 CHRNA5 0.48 9.73 0.36 6.1e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7124681 0.528 rs74608150 chr11:47696214 A/T cg20307385 chr11:47447363 PSMC3 0.42 9.51 0.35 3.86e-20 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs1401999 1.000 rs2872249 chr3:183636273 T/A cg20387954 chr3:183756860 HTR3D 0.44 9.91 0.36 1.28e-21 Anterior chamber depth; BRCA cis rs7599312 1.000 rs7599312 chr2:213413231 C/T cg16329650 chr2:213403929 ERBB4 0.45 9.94 0.37 9.46e-22 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10464366 1.000 rs10464366 chr7:39121500 A/T cg18850127 chr7:39170497 POU6F2 -0.41 -8.42 -0.32 2.41e-16 IgG glycosylation; BRCA cis rs2380220 0.541 rs9285413 chr6:96023439 G/A cg15832292 chr6:96025679 MANEA 0.57 8.54 0.32 9.87e-17 Behavioural disinhibition (generation interaction); BRCA cis rs2075371 0.611 rs1862045 chr7:134023412 A/G cg11752832 chr7:134001865 SLC35B4 0.42 9.22 0.34 4.12e-19 Mean platelet volume; BRCA cis rs78487399 0.710 rs17031133 chr2:43844833 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.57 8.83 0.33 1.03e-17 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA trans rs10242455 0.702 rs45461000 chr7:99052710 A/G cg09045935 chr12:6379348 NA 0.86 8.35 0.31 4.08e-16 Blood metabolite levels; BRCA trans rs587242 0.910 rs12751763 chr1:96997655 C/T cg10631902 chr5:14652156 NA 0.35 8.58 0.32 7.27e-17 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs733175 0.855 rs10018666 chr4:10004805 C/T cg00071950 chr4:10020882 SLC2A9 0.41 8.57 0.32 7.66e-17 Psychosis and Alzheimer's disease; BRCA cis rs7523273 0.565 rs2104303 chr1:207886684 C/T cg22525895 chr1:207977042 MIR29B2 -0.35 -8.21 -0.31 1.19e-15 Schizophrenia; BRCA cis rs67460515 0.596 rs4856700 chr3:160922951 A/C cg03342759 chr3:160939853 NMD3 -0.73 -15.02 -0.51 7.06e-44 Parkinson's disease; BRCA cis rs4478858 0.684 rs16834336 chr1:31751512 G/A cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs6964587 1.000 rs58965837 chr7:91585258 T/A cg17063962 chr7:91808500 NA 0.53 12.46 0.44 4.72e-32 Breast cancer; BRCA cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg12311346 chr5:56204834 C5orf35 0.58 11.94 0.43 8.33e-30 Initial pursuit acceleration; BRCA cis rs68170813 0.559 rs76208112 chr7:106964222 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.66 -0.32 3.98e-17 Coronary artery disease; BRCA cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg11833968 chr6:79620685 NA -0.44 -9.93 -0.37 1.06e-21 Intelligence (multi-trait analysis); BRCA cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg00631329 chr6:26305371 NA 0.39 11.74 0.42 5.99e-29 Educational attainment; BRCA cis rs10193935 1.000 rs10210866 chr2:42387879 A/G cg27598129 chr2:42591480 NA -0.86 -14.56 -0.5 1.11e-41 Colonoscopy-negative controls vs population controls; BRCA trans rs9929218 1.000 rs28450087 chr16:68803726 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.89 -0.48 1.66e-38 Colorectal cancer; BRCA cis rs11690935 0.921 rs3770445 chr2:172708919 T/C cg13550731 chr2:172543902 DYNC1I2 -0.91 -29.86 -0.76 2.63e-123 Schizophrenia; BRCA cis rs2251381 0.722 rs2251278 chr21:30529234 A/G cg08807101 chr21:30365312 RNF160 0.62 13.22 0.46 1.87e-35 Selective IgA deficiency; BRCA cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.32 8.74 0.33 2.11e-17 Monocyte percentage of white cells; BRCA cis rs651907 0.557 rs56291106 chr3:101377474 C/T cg12386194 chr3:101231763 SENP7 0.45 9.49 0.35 4.35e-20 Colorectal cancer; BRCA trans rs9325144 0.600 rs6582634 chr12:38748041 G/A cg23762105 chr12:34175262 ALG10 -0.41 -10.11 -0.37 2.08e-22 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg04450456 chr4:17643702 FAM184B 0.33 9.7 0.36 7.52e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9649213 0.593 rs7797943 chr7:97946902 T/C cg21770322 chr7:97807741 LMTK2 0.41 11.0 0.4 6.63e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.747 rs3806219 chr1:152972522 C/T cg25856811 chr1:152973957 SPRR3 0.35 9.26 0.34 3.09e-19 Inflammatory skin disease; BRCA cis rs1113500 0.805 rs11185244 chr1:108601147 C/T cg06207961 chr1:108661230 NA 0.34 8.13 0.31 2.27e-15 Growth-regulated protein alpha levels; BRCA cis rs2073300 1.000 rs6137959 chr20:23442640 T/C cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11252926 0.770 rs2124585 chr10:680428 G/A cg08603382 chr10:743973 NA 0.4 8.49 0.32 1.44e-16 Psychosis in Alzheimer's disease; BRCA cis rs11711311 1.000 rs2712348 chr3:113460614 C/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.05 -0.37 3.55e-22 IgG glycosylation; BRCA cis rs1468333 1.000 rs17171767 chr5:137493528 C/T cg27119451 chr5:137514611 BRD8;KIF20A -0.42 -8.94 -0.33 4.21e-18 Resting heart rate; BRCA cis rs1538970 1.000 rs17395553 chr1:45864761 C/T cg05343316 chr1:45956843 TESK2 0.63 12.86 0.45 7.65e-34 Platelet count; BRCA cis rs9790314 0.846 rs4856738 chr3:160986637 C/G cg03342759 chr3:160939853 NMD3 -0.67 -15.64 -0.53 6.51e-47 Morning vs. evening chronotype; BRCA cis rs151349 1.000 rs151346 chr20:57587040 C/A cg23907860 chr20:57583709 CTSZ -0.45 -10.87 -0.39 2.38e-25 Platelet distribution width; BRCA trans rs2727020 0.894 rs1880438 chr11:49370698 A/G cg15704280 chr7:45808275 SEPT13 -0.73 -15.05 -0.51 4.79e-44 Coronary artery disease; BRCA cis rs2153535 0.580 rs6905242 chr6:8471799 A/C cg23788917 chr6:8435910 SLC35B3 0.47 10.29 0.38 4.23e-23 Motion sickness; BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg10729496 chr3:10149963 C3orf24 0.47 8.84 0.33 8.98e-18 Alzheimer's disease; BRCA cis rs4631830 0.747 rs745180 chr10:51504493 A/C cg20129853 chr10:51489980 NA 0.31 8.33 0.31 4.92e-16 Prostate-specific antigen levels; BRCA trans rs61931739 0.534 rs11053131 chr12:34282109 A/G cg26384229 chr12:38710491 ALG10B 0.48 10.8 0.39 4.23e-25 Morning vs. evening chronotype; BRCA cis rs17376456 1.000 rs34756085 chr5:93556294 A/G cg25358565 chr5:93447407 FAM172A 1.25 19.37 0.61 4.3e-66 Diabetic retinopathy; BRCA cis rs67311347 1.000 rs72861689 chr3:40435890 A/G cg01475735 chr3:40494733 NA -0.39 -8.03 -0.3 4.55e-15 Renal cell carcinoma; BRCA cis rs7917772 0.628 rs4604806 chr10:104373904 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.31 0.49 1.79e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9527 0.590 rs10883839 chr10:104920341 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.2 0.37 9.52e-23 Arsenic metabolism; BRCA cis rs7737355 0.947 rs13174006 chr5:130963473 A/G cg06307176 chr5:131281290 NA 0.5 9.85 0.36 2.04e-21 Life satisfaction; BRCA cis rs3008870 0.959 rs2815353 chr1:67483372 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 21.16 0.64 1.05e-75 Lymphocyte percentage of white cells; BRCA cis rs7246657 0.598 rs28660259 chr19:37658681 C/T cg18154014 chr19:37997991 ZNF793 0.54 8.97 0.33 3.19e-18 Coronary artery calcification; BRCA cis rs1552244 0.882 rs13063098 chr3:10009919 G/A cg16606324 chr3:10149918 C3orf24 0.52 10.36 0.38 2.35e-23 Alzheimer's disease; BRCA cis rs6061231 1.000 rs11908473 chr20:60957770 C/G cg22601191 chr20:60968625 CABLES2 0.35 8.81 0.33 1.22e-17 Colorectal cancer; BRCA trans rs61931739 0.500 rs12832312 chr12:34031199 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.87e-20 Morning vs. evening chronotype; BRCA cis rs6963495 0.818 rs6961863 chr7:105180953 C/T cg19920283 chr7:105172520 RINT1 0.59 10.74 0.39 7.65e-25 Bipolar disorder (body mass index interaction); BRCA cis rs7772486 0.754 rs702319 chr6:146006117 T/C cg23711669 chr6:146136114 FBXO30 -0.75 -17.5 -0.57 2.48e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs7927771 0.757 rs1057233 chr11:47376448 G/A cg20307385 chr11:47447363 PSMC3 0.37 7.82 0.3 2.25e-14 Subjective well-being; BRCA cis rs62229266 0.804 rs56279140 chr21:37424361 C/T cg12218747 chr21:37451666 NA -0.33 -7.94 -0.3 9.24e-15 Mitral valve prolapse; BRCA cis rs17270561 0.609 rs1892248 chr6:25768914 C/T cg17691542 chr6:26056736 HIST1H1C 0.48 9.61 0.36 1.7e-20 Iron status biomarkers; BRCA cis rs7772486 0.712 rs6570726 chr6:146159460 T/C cg23711669 chr6:146136114 FBXO30 0.64 14.47 0.5 2.83e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs782590 0.869 rs782599 chr2:55847423 C/T cg18811423 chr2:55921094 PNPT1 0.71 22.36 0.66 3.18e-82 Metabolic syndrome; BRCA cis rs1568889 1.000 rs34140872 chr11:28335872 A/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 13.13 0.46 4.99e-35 Bipolar disorder; BRCA cis rs2712184 0.756 rs2541388 chr2:217664284 A/G cg05032264 chr2:217675019 NA 0.41 9.99 0.37 6.48e-22 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs1707322 0.691 rs11211175 chr1:46220884 C/G cg06784218 chr1:46089804 CCDC17 0.48 11.59 0.42 2.48e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs953387 1.000 rs10803550 chr2:136907790 C/T cg05194412 chr2:137003533 NA -0.37 -8.58 -0.32 7.26e-17 Arthritis (juvenile idiopathic); BRCA cis rs877282 0.891 rs12767062 chr10:797961 C/T cg17470449 chr10:769945 NA 0.5 8.57 0.32 7.78e-17 Uric acid levels; BRCA cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.64e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 0.735 rs11638767 chr15:76655938 T/C cg23625390 chr15:77176239 SCAPER -0.54 -13.18 -0.46 2.81e-35 Blood metabolite levels; BRCA cis rs9470366 0.545 rs4713999 chr6:36633069 A/G cg08179530 chr6:36648295 CDKN1A -0.51 -11.36 -0.41 2.38e-27 QRS duration; BRCA cis rs4642101 0.597 rs12638595 chr3:12819281 T/C cg24848339 chr3:12840334 CAND2 0.5 13.35 0.47 5.13e-36 QRS complex (12-leadsum); BRCA cis rs9921222 0.786 rs3848365 chr16:374617 C/T cg12437481 chr16:420112 MRPL28 -0.34 -7.85 -0.3 1.76e-14 Bone mineral density (spine);Bone mineral density; BRCA cis rs9818758 0.556 rs116432667 chr3:48947589 C/T cg00383909 chr3:49044727 WDR6 0.97 15.54 0.52 1.9e-46 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs950776 0.518 rs4886572 chr15:78837452 A/G cg06917634 chr15:78832804 PSMA4 -0.76 -17.81 -0.58 6.52e-58 Sudden cardiac arrest; BRCA cis rs1401999 0.628 rs7639048 chr3:183746044 A/G cg01324343 chr3:183735012 ABCC5 0.7 16.49 0.55 3.52e-51 Anterior chamber depth; BRCA cis rs7940866 1.000 rs7940866 chr11:130817579 A/T cg12179176 chr11:130786555 SNX19 -0.58 -12.41 -0.44 7.86e-32 Schizophrenia; BRCA cis rs6831352 0.918 rs35662508 chr4:100050974 C/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs28374715 0.578 rs7169543 chr15:41620405 T/C cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.8 -0.71 4.21e-101 Ulcerative colitis; BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 19.45 0.61 1.46e-66 Platelet count; BRCA cis rs2072499 0.838 rs2758619 chr1:156162559 A/G cg06970220 chr1:156163860 SLC25A44 0.39 9.45 0.35 6.04e-20 Testicular germ cell tumor; BRCA trans rs637571 0.522 rs1151512 chr11:65757533 G/A cg17712092 chr4:129076599 LARP1B 0.56 13.47 0.47 1.34e-36 Eosinophil percentage of white cells; BRCA cis rs943466 1.000 rs6921487 chr6:33749293 G/A cg25922239 chr6:33757077 LEMD2 -0.38 -8.4 -0.32 2.92e-16 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg06484146 chr7:12443880 VWDE -0.71 -9.89 -0.36 1.49e-21 Coronary artery disease; BRCA cis rs7847628 0.587 rs10760117 chr9:123586737 T/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.85 20.81 0.64 8.03e-74 Birth weight; BRCA cis rs9467773 0.620 rs2504592 chr6:26640951 C/G cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.33e-42 Intelligence (multi-trait analysis); BRCA cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg06212747 chr3:49208901 KLHDC8B 0.48 9.85 0.36 2.01e-21 Parkinson's disease; BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.84 15.2 0.52 9.03e-45 Platelet count; BRCA cis rs534126 0.778 rs10256011 chr7:142936243 G/A cg21852589 chr7:142981689 TMEM139 0.44 10.05 0.37 3.56e-22 Cancer; BRCA cis rs7264396 0.563 rs2425136 chr20:34344782 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.54 -0.42 3.9e-28 Total cholesterol levels; BRCA cis rs10733682 0.659 rs3861879 chr9:129464856 A/G cg00232160 chr9:129468157 NA 0.4 9.14 0.34 8.38e-19 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs698833 0.509 rs10198291 chr2:44539009 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.32 0.31 5.39e-16 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs7647973 0.554 rs13096480 chr3:49658084 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.14 -0.31 2.03e-15 Menarche (age at onset); BRCA cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.55 0.39 4.3e-24 Motion sickness; BRCA cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg18867708 chr6:26865862 GUSBL1 0.42 8.26 0.31 8.42e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs2014572 0.967 rs10421632 chr19:57764770 G/A cg24459738 chr19:57751996 ZNF805 -0.37 -8.59 -0.32 6.39e-17 Hyperactive-impulsive symptoms; BRCA cis rs6831352 0.879 rs29001208 chr4:100052539 A/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs2243480 1.000 rs313807 chr7:65499481 C/T cg18252515 chr7:66147081 NA -0.86 -12.42 -0.44 7.02e-32 Diabetic kidney disease; BRCA cis rs9811920 0.609 rs6440938 chr3:99652092 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.81 -0.55 9.16e-53 Axial length; BRCA trans rs9650657 0.538 rs11250093 chr8:10798828 C/T cg06636001 chr8:8085503 FLJ10661 0.47 9.58 0.35 2.04e-20 Neuroticism; BRCA cis rs7178424 0.967 rs933807 chr15:62274940 C/G cg00456672 chr15:62358751 C2CD4A 0.39 8.82 0.33 1.12e-17 Height; BRCA cis rs826838 0.872 rs826878 chr12:39088837 A/T cg13010199 chr12:38710504 ALG10B -0.41 -9.57 -0.35 2.35e-20 Heart rate; BRCA cis rs9986765 1.000 rs73452570 chr7:142817482 T/A cg15652212 chr7:142981776 TMEM139 0.55 9.19 0.34 5.62e-19 Cancer;Dermatomyositis; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg08470875 chr2:26401718 FAM59B 0.52 8.31 0.31 5.72e-16 Gut microbiome composition (summer); BRCA cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg00271210 chr6:167070053 RPS6KA2 -0.32 -8.6 -0.32 6.14e-17 Crohn's disease; BRCA cis rs9487051 0.724 rs13200047 chr6:109633244 T/C cg01475377 chr6:109611718 NA -0.45 -10.21 -0.37 9.28e-23 Reticulocyte fraction of red cells; BRCA cis rs55882075 0.765 rs34329357 chr5:179130408 G/C cg14593053 chr5:179126677 CANX 0.51 13.82 0.48 3.56e-38 Monocyte percentage of white cells; BRCA cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg17143192 chr8:8559678 CLDN23 0.54 10.3 0.38 3.9e-23 Obesity-related traits; BRCA trans rs7829975 0.688 rs7817376 chr8:8380530 C/T cg21775007 chr8:11205619 TDH -0.42 -8.71 -0.33 2.5e-17 Mood instability; BRCA cis rs1059312 0.932 rs4760593 chr12:129287220 A/G cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.3 0.35 2.23e-19 Systemic lupus erythematosus; BRCA cis rs17376456 0.825 rs13182631 chr5:93115701 A/G cg25358565 chr5:93447407 FAM172A 1.15 17.85 0.58 3.92e-58 Diabetic retinopathy; BRCA cis rs736408 0.677 rs678 chr3:52820981 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 10.69 0.39 1.2e-24 Bipolar disorder; BRCA cis rs12142240 0.698 rs45449893 chr1:46859024 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs2243480 1.000 rs56985706 chr7:65394562 C/T cg18252515 chr7:66147081 NA -0.82 -11.88 -0.43 1.52e-29 Diabetic kidney disease; BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.63 11.99 0.43 5.05e-30 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.26 0.49 2.83e-40 Motion sickness; BRCA cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg01475377 chr6:109611718 NA -0.52 -13.07 -0.46 9.12e-35 Reticulocyte fraction of red cells; BRCA cis rs11250464 0.794 rs11250487 chr10:1434168 C/A cg26394196 chr10:1453818 ADARB2 -0.36 -7.99 -0.3 6.45e-15 Radiation response; BRCA cis rs40363 0.645 rs250631 chr16:3523215 G/C cg21433313 chr16:3507492 NAT15 0.43 8.9 0.33 5.63e-18 Tuberculosis; BRCA cis rs6424115 0.594 rs10799802 chr1:24009544 C/T cg15997130 chr1:24165203 NA 0.35 8.07 0.3 3.46e-15 Immature fraction of reticulocytes; BRCA trans rs8073060 0.586 rs6505484 chr17:33993152 G/A cg19694781 chr19:47549865 TMEM160 -1.05 -21.6 -0.65 4.01e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs3942852 0.726 rs10742836 chr11:48175831 G/A cg03929089 chr4:120376271 NA -0.5 -9.33 -0.35 1.66e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs425277 0.628 rs262662 chr1:2085033 A/G cg04315214 chr1:2043799 PRKCZ -0.48 -12.7 -0.45 4.15e-33 Height; BRCA cis rs7246657 0.943 rs2891699 chr19:37920237 A/G cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA cis rs12950390 0.853 rs12451815 chr17:45855956 A/G cg24803719 chr17:45855879 NA -0.32 -8.46 -0.32 1.84e-16 IgG glycosylation; BRCA cis rs6690583 1.000 rs6690464 chr1:85466369 A/G cg11262906 chr1:85462892 MCOLN2 -0.51 -9.63 -0.36 1.33e-20 Serum sulfate level; BRCA cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg06808227 chr14:105710500 BRF1 -0.8 -15.93 -0.53 2.39e-48 Mean platelet volume;Platelet distribution width; BRCA cis rs6495367 1.000 rs3851677 chr15:79380869 C/T cg17916960 chr15:79447300 NA 0.33 7.96 0.3 7.93e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10504229 0.861 rs116923397 chr8:58185162 T/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.51 -0.44 2.72e-32 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA trans rs7615952 0.512 rs2979351 chr3:125363599 C/T cg07211511 chr3:129823064 LOC729375 -0.59 -10.73 -0.39 8.36e-25 Blood pressure (smoking interaction); BRCA cis rs701145 0.585 rs1727946 chr3:153826470 C/T cg12800244 chr3:153838788 SGEF 0.63 7.87 0.3 1.47e-14 Coronary artery disease; BRCA cis rs751728 0.717 rs3763260 chr6:33774070 C/T cg25922239 chr6:33757077 LEMD2 0.52 11.64 0.42 1.52e-28 Crohn's disease; BRCA cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.36 0.38 2.27e-23 Bipolar disorder; BRCA trans rs12310956 0.532 rs1525903 chr12:33964163 T/C cg26384229 chr12:38710491 ALG10B 0.52 11.18 0.4 1.26e-26 Morning vs. evening chronotype; BRCA cis rs2235642 0.928 rs9932984 chr16:1605051 A/G cg09065629 chr16:1709722 CRAMP1L 0.36 8.39 0.32 3.1e-16 Coronary artery disease; BRCA cis rs11190604 1.000 rs9420782 chr10:102235015 G/A cg07080220 chr10:102295463 HIF1AN 0.5 11.56 0.42 3.25e-28 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg07395648 chr5:131743802 NA 0.37 9.27 0.34 2.75e-19 Blood metabolite levels; BRCA cis rs738322 0.805 rs2235344 chr22:38518083 G/A cg25457927 chr22:38595422 NA -0.31 -11.35 -0.41 2.49e-27 Cutaneous nevi; BRCA cis rs11764590 0.694 rs4721321 chr7:2068470 A/G cg23422044 chr7:1970798 MAD1L1 -0.44 -9.46 -0.35 5.75e-20 Neuroticism; BRCA cis rs2276314 1.000 rs2298716 chr18:33552598 C/T cg05985134 chr18:33552581 C18orf21 0.71 13.6 0.47 3.54e-37 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2836974 0.897 rs68090597 chr21:40535633 A/G cg11890956 chr21:40555474 PSMG1 1.06 31.9 0.78 2.54e-134 Cognitive function; BRCA cis rs6782228 0.565 rs67445542 chr3:128330526 T/C cg16766828 chr3:128327626 NA -0.4 -8.89 -0.33 6.11e-18 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs1150668 0.830 rs2531831 chr6:28388765 C/G cg14547644 chr6:28411285 ZSCAN23 -0.35 -7.84 -0.3 1.96e-14 Pubertal anthropometrics; BRCA cis rs6912958 0.703 rs6903219 chr6:88096498 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.4 11.49 0.41 6.55e-28 Monocyte percentage of white cells; BRCA cis rs2243480 1.000 rs34637256 chr7:65360131 G/A cg18252515 chr7:66147081 NA -0.81 -11.34 -0.41 2.84e-27 Diabetic kidney disease; BRCA cis rs35110281 0.712 rs162345 chr21:44954155 T/G cg01579765 chr21:45077557 HSF2BP -0.4 -10.83 -0.39 3.18e-25 Mean corpuscular volume; BRCA cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg02187348 chr16:89574699 SPG7 -0.36 -8.08 -0.3 3.24e-15 Multiple myeloma (IgH translocation); BRCA cis rs35110281 0.548 rs2838350 chr21:45109972 T/C cg04455712 chr21:45112962 RRP1B 0.46 11.85 0.42 1.97e-29 Mean corpuscular volume; BRCA cis rs61990749 0.597 rs12887282 chr14:78200585 C/A cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.59 0.39 2.86e-24 Fibroblast growth factor basic levels; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.62 10.37 0.38 2.1e-23 Renal function-related traits (BUN); BRCA cis rs2011503 1.000 rs2060275 chr19:19536208 G/C cg15839431 chr19:19639596 YJEFN3 -0.42 -9.21 -0.34 4.63e-19 Bipolar disorder; BRCA cis rs2882667 0.861 rs10043676 chr5:138389561 C/T cg04439458 chr5:138467593 SIL1 -0.33 -9.07 -0.34 1.51e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10181042 0.565 rs62150982 chr2:61280675 T/C cg15711740 chr2:61764176 XPO1 0.37 9.2 0.34 5.18e-19 Crohn's disease; BRCA cis rs16910800 0.638 rs12273883 chr11:23164569 C/G cg20040320 chr11:23191996 NA 0.56 9.25 0.34 3.21e-19 Cancer; BRCA cis rs921968 0.548 rs13427522 chr2:219438359 C/T cg02176678 chr2:219576539 TTLL4 0.4 10.84 0.39 3.1e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs2415984 0.622 rs61993302 chr14:46949684 C/T cg14871534 chr14:47121158 RPL10L -0.33 -8.07 -0.3 3.56e-15 Number of children ever born; BRCA cis rs782590 0.764 rs935177 chr2:55826761 C/G cg18811423 chr2:55921094 PNPT1 0.69 21.1 0.64 2.14e-75 Metabolic syndrome; BRCA cis rs7824557 0.767 rs3808513 chr8:11157460 G/T cg21775007 chr8:11205619 TDH -0.62 -12.34 -0.44 1.56e-31 Retinal vascular caliber; BRCA cis rs853679 0.517 rs4713146 chr6:28111536 A/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -7.97 -0.3 7.07e-15 Depression; BRCA cis rs4423214 0.802 rs2276358 chr11:71184498 G/A cg05163923 chr11:71159392 DHCR7 -0.56 -11.35 -0.41 2.58e-27 Vitamin D levels; BRCA cis rs2191566 0.576 rs381759 chr19:44495145 A/G cg20607764 chr19:44506953 ZNF230 -0.37 -7.98 -0.3 6.83e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs6496932 0.563 rs2344083 chr15:85897432 T/C cg19183879 chr15:85880815 NA -0.43 -10.89 -0.4 1.94e-25 Central corneal thickness;Corneal structure; BRCA cis rs6860806 0.661 rs3763112 chr5:131586480 A/G cg18758796 chr5:131593413 PDLIM4 0.33 8.57 0.32 7.54e-17 Breast cancer; BRCA cis rs59698941 0.527 rs1032764 chr5:132185419 A/C cg14825688 chr5:132208181 LEAP2 -0.37 -8.61 -0.32 5.63e-17 Apolipoprotein A-IV levels; BRCA cis rs6459788 0.693 rs11981578 chr7:157250133 C/T cg22987457 chr7:157211561 NA 0.33 7.96 0.3 7.81e-15 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA cis rs12618769 0.597 rs2278208 chr2:99154229 C/T cg10123293 chr2:99228465 UNC50 0.44 8.5 0.32 1.3e-16 Bipolar disorder; BRCA trans rs9929218 0.551 rs2281850 chr16:68718750 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 -1.06 -32.76 -0.79 6.5e-139 Colorectal cancer; BRCA cis rs6539267 0.741 rs2279759 chr12:106694988 T/C cg00173435 chr12:106696525 TCP11L2 0.56 9.81 0.36 2.85e-21 Tourette syndrome; BRCA cis rs8017423 0.934 rs11159952 chr14:90684874 T/C cg04374321 chr14:90722782 PSMC1 0.71 18.43 0.59 3.71e-61 Mortality in heart failure; BRCA cis rs9649213 0.593 rs1076272 chr7:98031005 C/G cg01877450 chr7:97915802 BRI3 -0.38 -8.47 -0.32 1.7e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg13010199 chr12:38710504 ALG10B 0.42 8.84 0.33 8.99e-18 Bladder cancer; BRCA cis rs11758351 0.866 rs11757394 chr6:26206694 G/C cg01420254 chr6:26195488 NA 0.55 8.49 0.32 1.49e-16 Gout;Renal underexcretion gout; BRCA cis rs7590368 0.961 rs13432104 chr2:10960661 T/C cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.02e-15 Educational attainment (years of education); BRCA cis rs12540874 0.965 rs9791887 chr7:50661170 A/C cg18232548 chr7:50535776 DDC -0.37 -8.24 -0.31 9.46e-16 Systemic sclerosis; BRCA cis rs7264396 0.747 rs73283043 chr20:34383863 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.38 7.95 0.3 8.58e-15 Total cholesterol levels; BRCA cis rs600231 0.708 rs1784860 chr11:65240712 C/A cg01292856 chr11:65242576 NA 0.32 8.05 0.3 3.91e-15 Bone mineral density; BRCA cis rs9790314 0.586 rs1839491 chr3:161126429 C/A cg04691961 chr3:161091175 C3orf57 -0.39 -9.01 -0.34 2.32e-18 Morning vs. evening chronotype; BRCA cis rs7894051 1.000 rs11101721 chr10:135190358 C/G cg20534287 chr10:135191450 PAOX 0.51 8.9 0.33 5.53e-18 Lifespan; BRCA cis rs6540559 1.000 rs2073485 chr1:209962794 G/A cg25204440 chr1:209979598 IRF6 0.42 8.39 0.31 3.21e-16 Cleft lip with or without cleft palate; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.09 -0.34 1.27e-18 Total body bone mineral density; BRCA cis rs708547 0.874 rs1713978 chr4:57875879 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.53 -9.72 -0.36 6.46e-21 Response to bleomycin (chromatid breaks); BRCA cis rs72781680 0.611 rs78861366 chr2:24354428 A/G cg08917208 chr2:24149416 ATAD2B 0.55 8.28 0.31 7.02e-16 Lymphocyte counts; BRCA cis rs914187 1.000 rs914187 chr21:42619749 A/G cg21268422 chr21:42620091 BACE2 0.58 12.31 0.44 2.2e-31 Body mass index; BRCA cis rs6910061 1.000 rs6938867 chr6:11095303 A/G cg27233058 chr6:11094804 LOC221710 0.52 9.31 0.35 1.94e-19 Diabetic kidney disease; BRCA cis rs17376456 0.825 rs17372615 chr5:93124768 C/T cg21475434 chr5:93447410 FAM172A 0.67 8.75 0.33 1.86e-17 Diabetic retinopathy; BRCA cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg22862634 chr11:62369728 EML3;MTA2 0.49 12.22 0.44 5.22e-31 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6733011 0.508 rs925887 chr2:99514671 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.4 9.17 0.34 6.66e-19 Bipolar disorder; BRCA cis rs10504229 0.861 rs67042991 chr8:58191749 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg21782813 chr7:2030301 MAD1L1 0.41 11.1 0.4 2.63e-26 Bipolar disorder and schizophrenia; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.27 -0.41 5.58e-27 Gut microbiome composition (summer); BRCA cis rs9393692 0.840 rs9358915 chr6:26277268 G/A cg00631329 chr6:26305371 NA -0.44 -13.0 -0.46 1.8e-34 Educational attainment; BRCA trans rs4332037 0.851 rs10268609 chr7:1962163 A/C cg25206134 chr2:45395956 NA 0.48 8.4 0.32 2.99e-16 Bipolar disorder; BRCA cis rs4713118 0.824 rs9468223 chr6:27740666 C/T cg26587870 chr6:27730563 NA -0.41 -8.83 -0.33 9.71e-18 Parkinson's disease; BRCA cis rs12997796 0.503 rs4366909 chr2:87021001 G/A cg25203885 chr2:87302643 LOC285074 -0.52 -8.53 -0.32 1.07e-16 Schizophrenia; BRCA cis rs7586879 0.639 rs2033654 chr2:25103108 C/A cg01884057 chr2:25150051 NA 0.32 8.45 0.32 1.9e-16 Body mass index; BRCA trans rs11098499 0.863 rs3775848 chr4:120447724 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.28 0.31 7.45e-16 Corneal astigmatism; BRCA cis rs4722166 0.568 rs1880241 chr7:22759469 A/G cg05472934 chr7:22766657 IL6 0.38 9.93 0.37 1.09e-21 Lung cancer; BRCA cis rs10465746 0.725 rs4907188 chr1:84361608 C/T cg10977910 chr1:84465055 TTLL7 0.61 12.84 0.45 9.64e-34 Obesity-related traits; BRCA cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg03477792 chr4:77819574 ANKRD56 0.65 15.56 0.52 1.5e-46 Emphysema distribution in smoking; BRCA cis rs950776 0.720 rs11633223 chr15:78935476 T/C cg06917634 chr15:78832804 PSMA4 0.52 10.35 0.38 2.47e-23 Sudden cardiac arrest; BRCA cis rs1506636 0.962 rs10243279 chr7:123441262 T/A cg03229431 chr7:123269106 ASB15 0.56 12.31 0.44 2.09e-31 Plateletcrit;Platelet count; BRCA cis rs8032158 1.000 rs67505007 chr15:56196253 C/T cg02198044 chr15:56286336 NEDD4 -0.38 -9.03 -0.34 2.06e-18 Keloid; BRCA cis rs9682041 0.569 rs11914970 chr3:170112307 T/G cg11886554 chr3:170076028 SKIL 0.48 9.84 0.36 2.31e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs7975161 0.786 rs10861181 chr12:104651110 T/C cg25273343 chr12:104657179 TXNRD1 -0.5 -10.84 -0.39 3.07e-25 Toenail selenium levels; BRCA cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.46 0.5 3.27e-41 Colorectal cancer; BRCA cis rs10782582 0.609 rs5745394 chr1:76311731 G/A cg03433033 chr1:76189801 ACADM -0.39 -8.09 -0.3 3.06e-15 Daytime sleep phenotypes; BRCA cis rs2842992 0.915 rs2758321 chr6:160071611 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.53 10.85 0.39 2.66e-25 Age-related macular degeneration (geographic atrophy); BRCA cis rs7258465 0.965 rs2561043 chr19:18622683 A/T cg01065977 chr19:18549689 ISYNA1 -0.28 -8.28 -0.31 7.31e-16 Breast cancer; BRCA cis rs34330 0.562 rs10845615 chr12:12863470 C/T cg09462578 chr12:12878428 APOLD1 -0.67 -11.41 -0.41 1.39e-27 Systemic lupus erythematosus; BRCA cis rs8072100 0.713 rs2292346 chr17:45455473 G/A cg19784903 chr17:45786737 TBKBP1 -0.37 -8.69 -0.33 2.94e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs796364 0.951 rs281776 chr2:200834282 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 11.87 0.42 1.72e-29 Schizophrenia; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg27588902 chr6:42928151 GNMT -0.31 -10.4 -0.38 1.7e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2635047 1.000 rs2684825 chr18:44666415 T/C cg19077165 chr18:44547161 KATNAL2 -0.39 -8.14 -0.31 2.13e-15 Educational attainment; BRCA cis rs897080 0.515 rs2850290 chr2:44636055 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.09 0.34 1.21e-18 Height; BRCA cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg09555818 chr19:45449301 APOC2 0.47 12.21 0.43 5.72e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6762477 0.748 rs2073726 chr3:50223593 T/A cg05623727 chr3:50126028 RBM5 -0.37 -8.73 -0.33 2.27e-17 Menarche (age at onset); BRCA cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.75 -18.07 -0.58 3e-59 Chronic sinus infection; BRCA cis rs4820539 1.000 rs5751589 chr22:23475762 A/G cg14186256 chr22:23484241 RTDR1 -0.8 -24.36 -0.69 3.14e-93 Bone mineral density; BRCA cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg00504896 chr12:9437009 LOC642846 -0.46 -9.96 -0.37 7.79e-22 Breast size; BRCA cis rs67981189 0.593 rs8007425 chr14:71508200 A/G cg15816911 chr14:71606274 NA 0.38 8.63 0.32 4.7e-17 Schizophrenia; BRCA cis rs1707322 1.000 rs7519181 chr1:46387829 G/C cg06784218 chr1:46089804 CCDC17 0.45 10.86 0.39 2.51e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.53e-15 Tonsillectomy; BRCA cis rs1707322 0.964 rs7512395 chr1:46361177 G/A cg03146154 chr1:46216737 IPP 0.49 10.82 0.39 3.49e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 0.838 rs2173570 chr7:65762963 T/A cg11764359 chr7:65958608 NA -0.8 -19.27 -0.61 1.42e-65 Aortic root size; BRCA cis rs12367572 1.000 rs7304472 chr12:45262324 A/G cg04608330 chr12:45269318 NELL2 -0.64 -14.18 -0.49 7e-40 Gut microbiome composition (summer); BRCA cis rs113835537 0.529 rs11227501 chr11:66274072 T/C cg24851651 chr11:66362959 CCS 0.44 8.3 0.31 6.12e-16 Airway imaging phenotypes; BRCA cis rs644148 0.730 rs2117383 chr19:44978298 A/C cg15540054 chr19:45004280 ZNF180 0.49 9.58 0.35 2.1e-20 Personality dimensions; BRCA cis rs6964587 0.626 rs12704631 chr7:91523525 T/C cg17063962 chr7:91808500 NA -0.55 -12.71 -0.45 3.76e-33 Breast cancer; BRCA cis rs7811142 0.830 rs11761253 chr7:99939321 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.18 0.43 7.45e-31 Platelet count; BRCA cis rs703842 1.000 rs11172344 chr12:58193448 T/C cg00677455 chr12:58241039 CTDSP2 0.63 15.47 0.52 4.28e-46 Multiple sclerosis; BRCA cis rs2153535 0.580 rs1932285 chr6:8477719 T/G cg07606381 chr6:8435919 SLC35B3 0.64 14.11 0.49 1.43e-39 Motion sickness; BRCA cis rs1707322 0.682 rs10890335 chr1:46100394 G/C cg03146154 chr1:46216737 IPP 0.52 11.57 0.42 2.96e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2011503 0.597 rs8103992 chr19:19665643 A/C cg15839431 chr19:19639596 YJEFN3 0.37 8.73 0.33 2.18e-17 Bipolar disorder; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 13.27 0.46 1.13e-35 Lymphocyte counts; BRCA cis rs7178424 0.934 rs4775455 chr15:62347274 A/T cg00456672 chr15:62358751 C2CD4A -0.35 -7.95 -0.3 8.48e-15 Height; BRCA cis rs7582180 0.764 rs4851293 chr2:100925106 A/T cg14675211 chr2:100938903 LONRF2 0.49 11.2 0.4 1.07e-26 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.790 rs6923545 chr6:146244743 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.3 0.35 2.13e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.527 rs10943600 chr6:79611505 G/A cg18132916 chr6:79620363 NA -0.38 -7.81 -0.3 2.32e-14 Intelligence (multi-trait analysis); BRCA cis rs13315871 0.929 rs13322000 chr3:58286929 G/A cg20936604 chr3:58311152 NA -0.66 -8.46 -0.32 1.83e-16 Cholesterol, total; BRCA cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg18351406 chr4:77819688 ANKRD56 0.58 12.63 0.45 8.58e-33 Emphysema distribution in smoking; BRCA cis rs2841277 0.708 rs10083490 chr14:105402418 A/G cg19901468 chr14:105411992 AHNAK2 0.49 12.09 0.43 1.93e-30 Rheumatoid arthritis; BRCA trans rs6582630 0.555 rs10880602 chr12:38505660 T/C cg06521331 chr12:34319734 NA -0.45 -8.57 -0.32 7.61e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs9796 0.621 rs2928142 chr15:41470449 T/C cg18705301 chr15:41695430 NDUFAF1 0.37 7.92 0.3 1.03e-14 Menopause (age at onset); BRCA cis rs6121246 0.512 rs6058384 chr20:30276409 A/T cg21427119 chr20:30132790 HM13 -0.35 -8.05 -0.3 4.04e-15 Mean corpuscular hemoglobin; BRCA cis rs10464366 0.571 rs4723825 chr7:39157627 G/C cg10621924 chr7:39171070 POU6F2 0.38 7.82 0.3 2.21e-14 IgG glycosylation; BRCA cis rs1801251 0.752 rs709938 chr2:233746457 C/T cg25237894 chr2:233734115 C2orf82 -0.43 -13.39 -0.47 3.1e-36 Coronary artery disease; BRCA cis rs11718455 0.767 rs11130019 chr3:43989348 C/A cg08738300 chr3:44038990 NA 0.48 8.99 0.34 2.67e-18 Coronary artery disease; BRCA cis rs1577917 1.000 rs10455158 chr6:86672825 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.86 -0.42 1.86e-29 Response to antipsychotic treatment; BRCA cis rs847577 0.677 rs1495525 chr7:97826232 G/A cg24562669 chr7:97807699 LMTK2 -0.49 -12.85 -0.45 8.91e-34 Breast cancer; BRCA cis rs36051895 0.664 rs11793659 chr9:5109707 A/G cg02405213 chr9:5042618 JAK2 -0.5 -9.14 -0.34 8.2e-19 Pediatric autoimmune diseases; BRCA cis rs2425143 0.908 rs58448091 chr20:34325470 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.96 -0.33 3.53e-18 Blood protein levels; BRCA cis rs12887734 0.524 rs17791722 chr14:104286210 C/T cg01849466 chr14:104193079 ZFYVE21 -0.47 -10.89 -0.4 1.94e-25 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.97 -0.3 7.24e-15 Total body bone mineral density; BRCA cis rs4595586 0.545 rs3914596 chr12:39388538 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.44 0.35 6.82e-20 Morning vs. evening chronotype; BRCA cis rs10465746 0.780 rs11163865 chr1:84366917 C/T cg10977910 chr1:84465055 TTLL7 0.56 11.7 0.42 8.62e-29 Obesity-related traits; BRCA trans rs6479891 0.908 rs12412946 chr10:65289552 T/G cg14819942 chr15:35414228 NA 0.35 8.41 0.32 2.7e-16 Arthritis (juvenile idiopathic); BRCA trans rs61931739 0.500 rs34287388 chr12:34444626 C/A cg26384229 chr12:38710491 ALG10B 0.74 16.62 0.55 8.14e-52 Morning vs. evening chronotype; BRCA trans rs783540 0.900 rs12916980 chr15:83306447 C/G cg18393722 chr15:85113863 UBE2QP1 -0.28 -8.87 -0.33 7.55e-18 Schizophrenia; BRCA cis rs939658 0.935 rs954292 chr15:79449237 C/T cg17916960 chr15:79447300 NA 0.39 9.85 0.36 2.12e-21 Refractive error; BRCA cis rs6684514 1.000 rs12022194 chr1:156312331 T/A cg16558208 chr1:156270281 VHLL 0.37 8.32 0.31 5.29e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs17401966 0.931 rs2185252 chr1:10415912 T/C cg03954927 chr1:10346856 KIF1B 0.48 14.87 0.51 3.63e-43 Hepatocellular carcinoma; BRCA cis rs2836950 0.501 rs2070865 chr21:40715519 C/T cg11644478 chr21:40555479 PSMG1 -0.45 -9.34 -0.35 1.6e-19 Menarche (age at onset); BRCA cis rs10751667 1.000 rs6597965 chr11:964476 A/G ch.11.42038R chr11:967971 AP2A2 0.58 18.87 0.6 1.74e-63 Alzheimer's disease (late onset); BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg27094323 chr7:1216898 NA -0.36 -8.19 -0.31 1.45e-15 Longevity;Endometriosis; BRCA trans rs1945213 0.694 rs11227181 chr11:55856053 C/T cg15704280 chr7:45808275 SEPT13 0.65 11.44 0.41 1.06e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs7618501 0.699 rs1317154 chr3:49910084 T/C cg05623727 chr3:50126028 RBM5 0.43 10.16 0.37 1.41e-22 Intelligence (multi-trait analysis); BRCA cis rs7587476 0.784 rs34112702 chr2:215696002 A/G cg04004882 chr2:215674386 BARD1 0.65 11.96 0.43 6.71e-30 Neuroblastoma; BRCA cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg17063962 chr7:91808500 NA 0.57 13.13 0.46 4.95e-35 Breast cancer; BRCA cis rs10465746 0.935 rs12406984 chr1:84416215 C/G cg10977910 chr1:84465055 TTLL7 0.5 10.0 0.37 5.86e-22 Obesity-related traits; BRCA cis rs10504229 0.683 rs7463453 chr8:58112053 A/G cg20607798 chr8:58055168 NA 0.47 8.09 0.3 3.07e-15 Developmental language disorder (linguistic errors); BRCA cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.11 0.49 1.45e-39 Platelet count; BRCA trans rs62103177 0.608 rs613847 chr18:77845644 A/G cg05926928 chr17:57297772 GDPD1 -0.77 -10.8 -0.39 4.27e-25 Opioid sensitivity; BRCA cis rs6860806 0.631 rs6863548 chr5:131575920 G/A cg18758796 chr5:131593413 PDLIM4 0.34 9.0 0.34 2.47e-18 Breast cancer; BRCA cis rs250677 0.522 rs62378210 chr5:148384885 G/A cg12140854 chr5:148520817 ABLIM3 -0.41 -8.3 -0.31 6.24e-16 Breast cancer; BRCA cis rs4664304 0.710 rs9636280 chr2:160717852 C/T cg14819504 chr2:160761413 LY75 -0.37 -9.0 -0.34 2.54e-18 Crohn's disease;Inflammatory bowel disease; BRCA cis rs6964587 1.000 rs28410528 chr7:91647390 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.13 0.31 2.29e-15 Breast cancer; BRCA cis rs11148252 0.846 rs4886077 chr13:52998697 G/T cg00495681 chr13:53174319 NA 0.41 8.73 0.33 2.22e-17 Lewy body disease; BRCA cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg08219700 chr8:58056026 NA 0.44 7.89 0.3 1.3e-14 Developmental language disorder (linguistic errors); BRCA cis rs3784262 0.565 rs12914603 chr15:58350896 C/G cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.57 -0.35 2.36e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs826838 0.935 rs1684406 chr12:39127265 A/G cg26384229 chr12:38710491 ALG10B -0.62 -16.21 -0.54 8.87e-50 Heart rate; BRCA cis rs4363385 0.668 rs6587717 chr1:152984443 G/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.28 -0.31 7.23e-16 Inflammatory skin disease; BRCA cis rs36051895 0.623 rs11790680 chr9:5248768 C/T cg02405213 chr9:5042618 JAK2 -0.47 -8.25 -0.31 9.31e-16 Pediatric autoimmune diseases; BRCA cis rs9443645 0.870 rs9350799 chr6:79723651 C/A cg05283184 chr6:79620031 NA -0.38 -9.51 -0.35 3.95e-20 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg08470875 chr2:26401718 FAM59B 0.59 7.98 0.3 7.02e-15 Gut microbiome composition (summer); BRCA cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.03 0.49 3.57e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs72781680 0.898 rs72780111 chr2:23991146 G/A cg08917208 chr2:24149416 ATAD2B 0.89 12.98 0.46 2.32e-34 Lymphocyte counts; BRCA cis rs73001065 0.818 rs12610185 chr19:19721722 G/A cg03709012 chr19:19516395 GATAD2A 0.76 9.18 0.34 5.84e-19 LDL cholesterol; BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 15.86 0.53 4.91e-48 Alzheimer's disease; BRCA cis rs11051970 0.553 rs325419 chr12:32572460 A/G cg24626660 chr12:32551988 NA 0.28 8.24 0.31 9.87e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs765787 0.530 rs12917187 chr15:45538297 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg05890377 chr2:74357713 NA 0.52 11.05 0.4 4.46e-26 Gestational age at birth (maternal effect); BRCA cis rs28735056 0.591 rs62101204 chr18:77712832 G/A cg20368463 chr18:77673604 PQLC1 0.35 8.79 0.33 1.39e-17 Schizophrenia; BRCA cis rs208520 0.690 rs207082 chr6:66773796 G/A cg07460842 chr6:66804631 NA -1.01 -20.21 -0.62 1.32e-70 Exhaled nitric oxide output; BRCA trans rs10506458 0.915 rs56321182 chr12:63392023 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.2 -19.07 -0.6 1.58e-64 Hemostatic factors and hematological phenotypes; BRCA cis rs67478160 0.643 rs4900600 chr14:104291839 A/G cg01849466 chr14:104193079 ZFYVE21 -0.45 -11.55 -0.42 3.65e-28 Schizophrenia; BRCA cis rs9309473 0.950 rs11126412 chr2:73887634 A/T cg20560298 chr2:73613845 ALMS1 -0.46 -10.77 -0.39 5.93e-25 Metabolite levels; BRCA cis rs1882538 0.512 rs13241734 chr7:133122742 C/G cg10665199 chr7:133106180 EXOC4 0.45 9.18 0.34 6.1e-19 Intelligence (multi-trait analysis); BRCA cis rs919433 0.680 rs3792160 chr2:198403519 G/A cg00792783 chr2:198669748 PLCL1 0.36 8.36 0.31 3.88e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs78456975 0.941 rs11886649 chr2:1567757 A/G cg01028140 chr2:1542097 TPO -0.72 -13.92 -0.48 1.14e-38 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs858239 0.600 rs6960001 chr7:23130876 T/C cg23682824 chr7:23144976 KLHL7 0.45 12.23 0.44 4.63e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs737337 0.623 rs4804154 chr19:11334179 C/T cg00586551 chr19:11347513 LOC55908;DOCK6 0.55 10.11 0.37 2.24e-22 HDL cholesterol;HDL cholesterol levels; BRCA cis rs10876993 0.890 rs7963927 chr12:58046272 T/G cg00677455 chr12:58241039 CTDSP2 -0.35 -7.9 -0.3 1.19e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs651907 0.557 rs34457525 chr3:101435225 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.14 0.49 1.06e-39 Colorectal cancer; BRCA cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 9.04 0.34 1.93e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs9810890 1.000 rs73196983 chr3:128452500 G/T cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs2645694 0.626 rs12502590 chr4:77823642 G/A cg18351406 chr4:77819688 ANKRD56 0.62 14.07 0.49 2.2e-39 Emphysema distribution in smoking; BRCA cis rs2882667 0.931 rs10069528 chr5:138354027 A/G cg04439458 chr5:138467593 SIL1 -0.34 -9.17 -0.34 6.17e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7707921 0.881 rs73134739 chr5:81370760 T/C cg15871215 chr5:81402204 ATG10 -0.39 -8.12 -0.31 2.42e-15 Breast cancer; BRCA cis rs7666738 0.830 rs890470 chr4:98923435 A/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1215050 0.755 rs1238462 chr4:98850603 A/G cg05340658 chr4:99064831 C4orf37 -0.43 -9.8 -0.36 3.27e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2115536 1.000 rs7163338 chr15:80198408 C/G cg00225070 chr15:80189496 MTHFS 0.41 10.01 0.37 5.41e-22 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs875971 1.000 rs875971 chr7:65617595 A/G cg18876405 chr7:65276391 NA -0.56 -13.8 -0.48 4.16e-38 Aortic root size; BRCA cis rs10788264 0.621 rs7907952 chr10:124056774 C/T cg09507567 chr10:124027408 NA -0.39 -8.19 -0.31 1.47e-15 Total body bone mineral density; BRCA trans rs7613875 0.620 rs17657688 chr3:50033228 C/T cg21659725 chr3:3221576 CRBN -0.34 -8.27 -0.31 7.54e-16 Body mass index; BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg26314531 chr2:26401878 FAM59B 0.95 16.54 0.55 2.07e-51 Gut microbiome composition (summer); BRCA cis rs13108904 0.875 rs73069950 chr4:1276045 C/A cg05665937 chr4:1216051 CTBP1 -0.38 -8.0 -0.3 5.94e-15 Obesity-related traits; BRCA cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.65 0.32 4.01e-17 Diabetic retinopathy; BRCA cis rs7927592 0.913 rs3824850 chr11:68341873 A/G cg20283391 chr11:68216788 NA -0.46 -8.97 -0.33 3.25e-18 Total body bone mineral density; BRCA cis rs1008375 0.932 rs13109475 chr4:17677565 C/G cg15017067 chr4:17643749 FAM184B -0.26 -7.9 -0.3 1.22e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.57 13.09 0.46 7.21e-35 Personality dimensions; BRCA cis rs514406 0.505 rs835609 chr1:53170494 T/C cg08859206 chr1:53392774 SCP2 -0.4 -8.68 -0.32 3.28e-17 Monocyte count; BRCA cis rs2762353 0.904 rs13197514 chr6:25785991 C/T cg03517284 chr6:25882590 NA 0.48 10.84 0.39 3.03e-25 Blood metabolite levels; BRCA cis rs2637266 0.935 rs4353214 chr10:78393149 C/T cg18941641 chr10:78392320 NA -0.34 -7.84 -0.3 1.93e-14 Pulmonary function; BRCA cis rs875971 0.545 rs2707851 chr7:66089165 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.54 -10.19 -0.37 1.06e-22 Aortic root size; BRCA cis rs11583043 0.872 rs1326380 chr1:101293753 G/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.38 8.34 0.31 4.51e-16 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs9858542 0.953 rs35115732 chr3:49475155 T/C cg07274523 chr3:49395745 GPX1 0.46 7.84 0.3 1.84e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs8072100 0.790 rs1962307 chr17:45707871 A/G cg19784903 chr17:45786737 TBKBP1 -0.34 -8.02 -0.3 5.07e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7829975 0.688 rs6995407 chr8:8384647 C/G cg14343924 chr8:8086146 FLJ10661 0.39 8.15 0.31 1.88e-15 Mood instability; BRCA cis rs11098499 0.909 rs73842633 chr4:120375464 G/A cg09307838 chr4:120376055 NA 0.72 15.36 0.52 1.52e-45 Corneal astigmatism; BRCA cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg13770153 chr20:60521292 NA -0.42 -9.45 -0.35 6.5e-20 Body mass index; BRCA cis rs9467711 0.591 rs35335639 chr6:26038681 C/G cg21479132 chr6:26055353 NA 0.58 8.16 0.31 1.77e-15 Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.513 rs2200555 chr12:33899381 C/G cg26384229 chr12:38710491 ALG10B 0.46 10.77 0.39 5.91e-25 Morning vs. evening chronotype; BRCA cis rs13046373 0.535 rs13051135 chr21:32005278 G/A cg24082983 chr21:31802169 KRTAP13-4 0.33 8.25 0.31 9.08e-16 HDL cholesterol; BRCA cis rs6815814 0.950 rs5743556 chr4:38806851 A/G cg02016764 chr4:38805732 TLR1 -0.6 -9.56 -0.35 2.42e-20 Breast cancer; BRCA cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg11663144 chr21:46675770 NA -0.61 -13.91 -0.48 1.22e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs7618501 0.635 rs34080578 chr3:50026029 A/C cg21659725 chr3:3221576 CRBN 0.5 12.72 0.45 3.48e-33 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs55881798 chr8:58106406 T/C cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.790 rs2249386 chr6:146186611 G/A cg23711669 chr6:146136114 FBXO30 0.8 19.17 0.6 4.69e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs6582630 0.502 rs11520234 chr12:38255005 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.35 0.31 4.19e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2991971 1.000 rs2993262 chr1:46013733 G/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.34 -7.82 -0.3 2.26e-14 High light scatter reticulocyte count; BRCA cis rs6815814 0.898 rs5743592 chr4:38803063 A/G cg06935464 chr4:38784597 TLR10 0.49 8.27 0.31 7.85e-16 Breast cancer; BRCA cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg21427119 chr20:30132790 HM13 -0.43 -9.0 -0.34 2.54e-18 Mean corpuscular hemoglobin; BRCA cis rs897984 0.542 rs7197717 chr16:31083075 A/C cg00531865 chr16:30841666 NA -0.38 -9.11 -0.34 1.09e-18 Dementia with Lewy bodies; BRCA trans rs526821 0.595 rs565859 chr11:55297367 T/C cg15704280 chr7:45808275 SEPT13 -0.41 -7.83 -0.3 2e-14 Pediatric bone mineral density (spine); BRCA cis rs1183201 0.505 rs1165201 chr6:25874823 A/C cg12310025 chr6:25882481 NA -0.75 -19.81 -0.62 1.95e-68 Uric acid levels; BRCA cis rs9815354 0.680 rs73073239 chr3:42014597 G/C cg03022575 chr3:42003672 ULK4 0.79 10.08 0.37 2.84e-22 Pulse pressure;Diastolic blood pressure; BRCA trans rs35110281 0.837 rs2838343 chr21:45078035 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.01 0.3 5.61e-15 Mean corpuscular volume; BRCA cis rs6964587 0.967 rs34040612 chr7:91798916 G/T cg22117172 chr7:91764530 CYP51A1 0.24 8.43 0.32 2.33e-16 Breast cancer; BRCA cis rs7666738 0.830 rs7672127 chr4:98938477 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.89 0.56 3.65e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4423214 1.000 rs4944957 chr11:71168035 C/T cg05163923 chr11:71159392 DHCR7 -0.6 -13.53 -0.47 7.21e-37 Vitamin D levels; BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26119090 chr2:26468346 HADHA;HADHB 0.6 11.66 0.42 1.27e-28 Gut microbiome composition (summer); BRCA cis rs372883 0.600 rs2832295 chr21:30739843 C/T cg24692254 chr21:30365293 RNF160 0.46 10.16 0.37 1.39e-22 Pancreatic cancer; BRCA cis rs4919087 1.000 rs11189122 chr10:99072595 G/A cg25902810 chr10:99078978 FRAT1 0.52 11.76 0.42 4.9e-29 Monocyte count; BRCA cis rs12618769 0.597 rs4850875 chr2:99069815 A/G cg10123293 chr2:99228465 UNC50 0.41 8.09 0.3 3.07e-15 Bipolar disorder; BRCA cis rs2075371 0.611 rs13235296 chr7:134019192 A/G cg20476274 chr7:133979776 SLC35B4 -0.52 -12.84 -0.45 9.94e-34 Mean platelet volume; BRCA cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg04450456 chr4:17643702 FAM184B 0.37 11.02 0.4 5.63e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 1.000 rs17032414 chr3:10158302 C/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 17.22 0.56 6.76e-55 Alzheimer's disease; BRCA cis rs7568458 0.709 rs762684 chr2:85782023 G/A cg02493740 chr2:85810744 VAMP5 -0.54 -11.2 -0.41 1.01e-26 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs11583043 1.000 rs6675353 chr1:101459625 A/T cg16556008 chr1:101360663 SLC30A7;EXTL2 0.36 7.87 0.3 1.47e-14 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg05283184 chr6:79620031 NA -0.44 -11.4 -0.41 1.61e-27 Intelligence (multi-trait analysis); BRCA cis rs1506636 1.000 rs2429617 chr7:123418027 A/G cg03229431 chr7:123269106 ASB15 0.61 13.54 0.47 6.54e-37 Plateletcrit;Platelet count; BRCA cis rs870825 0.616 rs7659201 chr4:185632013 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.4 0.57 8.32e-56 Blood protein levels; BRCA trans rs1973993 0.561 rs7554152 chr1:96987865 G/C cg10631902 chr5:14652156 NA -0.41 -10.11 -0.37 2.16e-22 Weight; BRCA cis rs1355223 0.583 rs2941041 chr11:34874734 A/C cg11058730 chr11:34937778 PDHX;APIP 0.71 16.69 0.55 3.38e-52 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1552244 1.000 rs58275763 chr3:10143274 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.69 -12.85 -0.45 9.29e-34 Alzheimer's disease; BRCA cis rs250677 0.687 rs250679 chr5:148434952 A/T cg23229984 chr5:148520753 ABLIM3 -0.34 -8.37 -0.31 3.52e-16 Breast cancer; BRCA cis rs7258465 0.931 rs8107351 chr19:18612758 G/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.63 -0.32 4.88e-17 Breast cancer; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg03188948 chr7:1209495 NA 0.83 11.33 0.41 2.93e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.77 0.62 3.21e-68 Platelet count; BRCA cis rs4974559 0.947 rs28711287 chr4:1346682 G/C cg02980000 chr4:1222292 CTBP1 0.76 12.85 0.45 9.05e-34 Systolic blood pressure; BRCA cis rs6831352 0.918 rs29001199 chr4:100053891 A/G cg12011299 chr4:100065546 ADH4 -0.5 -11.51 -0.41 5.46e-28 Alcohol dependence; BRCA cis rs208520 0.802 rs208499 chr6:66932146 C/T cg07460842 chr6:66804631 NA -0.82 -14.6 -0.5 6.82e-42 Exhaled nitric oxide output; BRCA cis rs7523273 0.565 rs12733108 chr1:207887210 C/T cg22525895 chr1:207977042 MIR29B2 0.33 7.86 0.3 1.62e-14 Schizophrenia; BRCA cis rs7246967 0.611 rs73022711 chr19:22875404 G/A cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs2153535 0.580 rs9406161 chr6:8466144 G/T cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs10493773 1.000 rs7523292 chr1:86134992 A/G cg17807903 chr1:86174739 ZNHIT6 -0.45 -9.22 -0.34 4.23e-19 Urate levels in overweight individuals; BRCA cis rs354225 0.586 rs966003 chr2:54884870 C/T cg26097391 chr2:54893211 SPTBN1 0.28 8.39 0.32 3.06e-16 Schizophrenia; BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg00802000 chr16:706648 WDR90 -0.39 -9.39 -0.35 1.02e-19 Height; BRCA cis rs7552404 1.000 rs9662166 chr1:76235906 C/A cg22875332 chr1:76189707 ACADM 0.63 12.95 0.46 3.11e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6964587 1.000 rs6976122 chr7:91610962 T/C cg17063962 chr7:91808500 NA 0.53 12.51 0.44 2.79e-32 Breast cancer; BRCA cis rs4566357 0.615 rs4350744 chr2:227918146 A/T cg05526886 chr2:227700861 RHBDD1 -0.4 -8.18 -0.31 1.51e-15 Coronary artery disease; BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg00166722 chr3:10149974 C3orf24 0.58 11.34 0.41 2.64e-27 Alzheimer's disease; BRCA cis rs17401966 0.894 rs11587309 chr1:10446596 G/T cg03954927 chr1:10346856 KIF1B 0.47 14.23 0.49 4.3e-40 Hepatocellular carcinoma; BRCA cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg05283184 chr6:79620031 NA -0.39 -9.97 -0.37 7.68e-22 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.864 rs11039917 chr11:48695428 G/A cg00717180 chr2:96193071 NA -0.28 -7.9 -0.3 1.26e-14 HDL cholesterol; BRCA trans rs2980439 0.818 rs2948294 chr8:8094961 A/G cg16141378 chr3:129829833 LOC729375 -0.39 -9.24 -0.34 3.53e-19 Neuroticism; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg14004847 chr7:1930337 MAD1L1 -0.44 -8.95 -0.33 3.78e-18 Bipolar disorder and schizophrenia; BRCA cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg07493874 chr5:1342172 CLPTM1L -0.54 -15.27 -0.52 4.09e-45 Lung cancer; BRCA cis rs1401999 0.628 rs1520195 chr3:183736882 G/A cg01324343 chr3:183735012 ABCC5 0.7 16.58 0.55 1.32e-51 Anterior chamber depth; BRCA cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.06 0.46 1.02e-34 Bipolar disorder; BRCA cis rs8062405 0.755 rs4788078 chr16:28559981 G/A cg16576597 chr16:28551801 NUPR1 0.36 9.68 0.36 8.82e-21 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9646954 0.560 rs4149507 chr2:101032745 C/T cg14675211 chr2:100938903 LONRF2 0.51 11.26 0.41 5.84e-27 Intelligence (multi-trait analysis); BRCA cis rs2011503 0.941 rs11670775 chr19:19649636 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.15 -0.34 7.45e-19 Bipolar disorder; BRCA cis rs2882667 0.537 rs7701338 chr5:138405994 C/T cg04439458 chr5:138467593 SIL1 -0.31 -8.44 -0.32 2.14e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA trans rs7615952 0.558 rs17334039 chr3:125540308 A/G cg07211511 chr3:129823064 LOC729375 -0.77 -14.78 -0.5 9.85e-43 Blood pressure (smoking interaction); BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg00106254 chr7:1943704 MAD1L1 -0.37 -8.99 -0.34 2.8e-18 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs2592102 chr2:233726772 G/T cg08000102 chr2:233561755 GIGYF2 -0.63 -13.77 -0.48 5.96e-38 Coronary artery disease; BRCA cis rs9487051 1.000 rs1341271 chr6:109617542 A/T cg12927641 chr6:109611667 NA -0.35 -8.65 -0.32 4.3e-17 Reticulocyte fraction of red cells; BRCA cis rs27434 0.583 rs34760 chr5:96153491 T/C cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.2e-33 Ankylosing spondylitis; BRCA trans rs634534 0.562 rs661335 chr11:65754061 G/A cg17712092 chr4:129076599 LARP1B 0.54 13.03 0.46 1.34e-34 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs12310956 0.532 rs7955514 chr12:33978737 G/A cg06521331 chr12:34319734 NA -0.62 -11.21 -0.41 9.53e-27 Morning vs. evening chronotype; BRCA cis rs11690935 0.959 rs75922913 chr2:172620152 T/C cg13550731 chr2:172543902 DYNC1I2 -0.91 -29.23 -0.76 6.7e-120 Schizophrenia; BRCA cis rs6484504 0.576 rs16922084 chr11:31371109 C/T cg06552810 chr11:31128660 NA 0.4 8.73 0.33 2.16e-17 Red blood cell count; BRCA cis rs61931739 0.500 rs11053177 chr12:34412829 G/A cg06521331 chr12:34319734 NA -0.51 -10.15 -0.37 1.58e-22 Morning vs. evening chronotype; BRCA cis rs6484504 0.600 rs208063 chr11:31159777 C/T cg06552810 chr11:31128660 NA -0.39 -8.62 -0.32 5.39e-17 Red blood cell count; BRCA trans rs7944735 0.517 rs12274550 chr11:48196752 C/A cg15704280 chr7:45808275 SEPT13 0.56 8.77 0.33 1.67e-17 Intraocular pressure; BRCA trans rs12517041 1.000 rs58571178 chr5:23294196 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs36051895 0.632 rs7040922 chr9:5174829 A/G cg02405213 chr9:5042618 JAK2 0.46 8.85 0.33 8.75e-18 Pediatric autoimmune diseases; BRCA trans rs7618501 1.000 rs7431106 chr3:49808374 G/A cg21659725 chr3:3221576 CRBN 0.72 22.05 0.66 1.5e-80 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA cis rs11250464 0.833 rs4554799 chr10:1407728 C/T cg08668359 chr10:1443807 ADARB2 0.48 9.52 0.35 3.49e-20 Radiation response; BRCA cis rs754466 0.580 rs10762763 chr10:79560803 C/G cg17075019 chr10:79541650 NA -0.75 -19.32 -0.61 7.89e-66 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17345786 1.000 rs3804775 chr3:101306507 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.57 11.93 0.43 9.33e-30 Colonoscopy-negative controls vs population controls; BRCA trans rs3733585 0.673 rs6849729 chr4:9958732 T/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2204008 0.837 rs11612397 chr12:38357455 T/C cg06521331 chr12:34319734 NA -0.46 -8.54 -0.32 9.43e-17 Bladder cancer; BRCA trans rs7615952 0.641 rs12488180 chr3:125782236 C/T cg07211511 chr3:129823064 LOC729375 -0.63 -11.21 -0.41 9.17e-27 Blood pressure (smoking interaction); BRCA cis rs2370759 0.945 rs74625866 chr10:32597618 A/T cg18270830 chr10:32634957 EPC1 0.56 9.73 0.36 5.86e-21 Sexual dysfunction (female); BRCA cis rs910316 0.737 rs175045 chr14:75475275 A/C cg11812906 chr14:75593930 NEK9 -0.53 -11.55 -0.42 3.63e-28 Height; BRCA cis rs7666738 0.830 rs13140676 chr4:98804978 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.94 0.51 1.7e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs11229555 0.645 rs11229445 chr11:58199458 G/A cg15696309 chr11:58395628 NA -0.45 -9.69 -0.36 8.44e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs11051970 0.879 rs2467065 chr12:32586065 A/G cg24626660 chr12:32551988 NA 0.28 8.03 0.3 4.67e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs77106637 1.000 rs3862791 chr11:72501002 C/T cg03713592 chr11:72463424 ARAP1 0.94 13.57 0.47 4.97e-37 Type 2 diabetes; BRCA cis rs10733682 0.659 rs1887970 chr9:129464827 C/T cg00232160 chr9:129468157 NA 0.36 8.32 0.31 5.48e-16 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11874712 1.000 rs28699609 chr18:43674879 A/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.05 0.3 4.16e-15 Migraine - clinic-based; BRCA cis rs9611565 0.512 rs5758464 chr22:42171300 A/G cg03806693 chr22:41940476 POLR3H 0.89 13.72 0.48 9.65e-38 Vitiligo; BRCA cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.5 8.95 0.33 3.75e-18 Mean platelet volume; BRCA cis rs8114671 0.836 rs745849 chr20:33572178 G/A cg07148914 chr20:33460835 GGT7 -0.43 -9.22 -0.34 4.16e-19 Height; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg10862848 chr6:42927986 GNMT -0.35 -14.58 -0.5 9.38e-42 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs17125944 0.505 rs74642116 chr14:53213507 A/G cg13660082 chr14:53194042 PSMC6 -0.57 -8.46 -0.32 1.76e-16 Alzheimer's disease (late onset); BRCA trans rs35110281 0.811 rs2838337 chr21:45072621 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.5 0.38 6.63e-24 Mean corpuscular volume; BRCA cis rs10782582 0.609 rs1630587 chr1:76399787 T/C cg03433033 chr1:76189801 ACADM -0.4 -8.44 -0.32 2.16e-16 Daytime sleep phenotypes; BRCA cis rs78456975 0.527 rs10184112 chr2:1571112 A/G cg01028140 chr2:1542097 TPO -0.58 -11.82 -0.42 2.63e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs1113500 0.799 rs1777459 chr1:108584999 G/C cg06207961 chr1:108661230 NA -0.4 -9.73 -0.36 6.02e-21 Growth-regulated protein alpha levels; BRCA cis rs838147 0.733 rs12975781 chr19:49249698 A/G cg13540341 chr19:49222985 MAMSTR -0.3 -7.92 -0.3 1.09e-14 Dietary macronutrient intake; BRCA cis rs9463078 0.715 rs9357459 chr6:44782562 C/T cg25276700 chr6:44698697 NA -0.36 -8.31 -0.31 5.79e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs10504073 0.647 rs62507245 chr8:50006939 A/T cg00325661 chr8:49890786 NA 0.44 12.45 0.44 4.95e-32 Blood metabolite ratios; BRCA cis rs921968 0.541 rs17462853 chr2:219345637 T/G cg10223061 chr2:219282414 VIL1 0.3 8.48 0.32 1.58e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs35849525 0.814 rs35491931 chr3:49993462 T/A cg14019146 chr3:50243930 SLC38A3 -0.57 -11.67 -0.42 1.19e-28 Intelligence (multi-trait analysis); BRCA cis rs3925075 0.966 rs12935192 chr16:31359330 G/A cg02846316 chr16:31340340 ITGAM 0.53 12.94 0.46 3.34e-34 IgA nephropathy; BRCA cis rs7267979 0.933 rs2424708 chr20:25281398 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.52 0.32 1.14e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9309711 0.736 rs13412581 chr2:3497187 G/A cg16153549 chr2:3496821 NA -0.46 -10.6 -0.39 2.67e-24 Neurofibrillary tangles; BRCA cis rs2153535 0.601 rs9505474 chr6:8539794 C/G cg07606381 chr6:8435919 SLC35B3 0.64 14.02 0.49 3.85e-39 Motion sickness; BRCA cis rs1707322 0.896 rs785518 chr1:46568422 A/T cg03146154 chr1:46216737 IPP -0.43 -9.42 -0.35 8.22e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 0.731 rs5745445 chr1:76344332 G/A cg10523679 chr1:76189770 ACADM 0.69 12.27 0.44 3.21e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11098499 0.955 rs13113112 chr4:120156040 C/T cg09307838 chr4:120376055 NA 0.63 12.27 0.44 3.07e-31 Corneal astigmatism; BRCA cis rs2249625 0.504 rs2496508 chr6:72891398 A/G cg18830697 chr6:72922368 RIMS1 -0.63 -14.33 -0.49 1.35e-40 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA trans rs10838798 0.504 rs11039632 chr11:48297280 C/T cg03929089 chr4:120376271 NA -0.44 -8.32 -0.31 5.47e-16 Height; BRCA cis rs7949030 0.688 rs11231155 chr11:62365619 A/G cg22862634 chr11:62369728 EML3;MTA2 0.51 12.31 0.44 2.13e-31 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4988958 0.565 rs3755265 chr2:103052816 C/A cg03938978 chr2:103052716 IL18RAP 0.29 8.48 0.32 1.53e-16 Asthma (childhood onset); BRCA trans rs6582630 0.502 rs4385963 chr12:38295264 G/A cg06521331 chr12:34319734 NA -0.47 -8.83 -0.33 1.02e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs1862618 0.853 rs2432195 chr5:56120413 C/T cg03609598 chr5:56110824 MAP3K1 -0.45 -8.02 -0.3 5.19e-15 Initial pursuit acceleration; BRCA cis rs9733 0.596 rs6661872 chr1:150628357 C/G cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg18479299 chr3:125709523 NA -0.54 -8.39 -0.32 3.1e-16 Blood pressure (smoking interaction); BRCA cis rs2836950 0.565 rs2836943 chr21:40592611 C/T cg11644478 chr21:40555479 PSMG1 -0.52 -10.97 -0.4 8.72e-26 Menarche (age at onset); BRCA cis rs1003719 0.788 rs2835593 chr21:38465873 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.11 0.49 1.43e-39 Eye color traits; BRCA cis rs2835872 0.737 rs1787404 chr21:39049362 C/T cg06728970 chr21:39037746 KCNJ6 -0.33 -8.7 -0.33 2.84e-17 Electroencephalographic traits in alcoholism; BRCA cis rs5167 0.504 rs7246900 chr19:45454236 G/A cg09555818 chr19:45449301 APOC2 0.47 12.17 0.43 8.45e-31 Blood protein levels; BRCA cis rs12477438 0.501 rs17759607 chr2:99737005 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.88 0.64 3.29e-74 Chronic sinus infection; BRCA cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg24642439 chr20:33292090 TP53INP2 -0.53 -11.54 -0.42 4.13e-28 Glomerular filtration rate (creatinine); BRCA trans rs61931739 0.500 rs2389269 chr12:34034179 C/T cg26384229 chr12:38710491 ALG10B 0.68 14.34 0.49 1.23e-40 Morning vs. evening chronotype; BRCA cis rs2425143 0.818 rs11700299 chr20:34548865 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.96 -0.3 8.03e-15 Blood protein levels; BRCA cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg01579765 chr21:45077557 HSF2BP 0.39 10.62 0.39 2.3e-24 Mean corpuscular volume; BRCA trans rs208520 0.661 rs7740835 chr6:66865548 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.56 -0.63 1.76e-72 Exhaled nitric oxide output; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg22764044 chr5:178986830 RUFY1 0.51 14.25 0.49 3.37e-40 Lung cancer; BRCA cis rs7618501 0.521 rs952594 chr3:49908023 G/A cg24110177 chr3:50126178 RBM5 -0.52 -15.43 -0.52 6.61e-46 Intelligence (multi-trait analysis); BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg19913688 chr11:428466 ANO9 -0.67 -9.76 -0.36 4.67e-21 Body mass index; BRCA cis rs2019137 0.936 rs902696 chr2:113954879 G/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.56 11.02 0.4 5.8e-26 Lymphocyte counts; BRCA trans rs9951602 0.512 rs8089247 chr18:76651467 C/A cg02800362 chr5:177631904 HNRNPAB 0.77 17.9 0.58 2.09e-58 Obesity-related traits; BRCA cis rs826838 0.900 rs11169301 chr12:39128497 C/A cg13010199 chr12:38710504 ALG10B 0.53 11.32 0.41 3.31e-27 Heart rate; BRCA cis rs8072100 0.817 rs9905581 chr17:45547185 C/T cg25173405 chr17:45401733 C17orf57 -0.54 -11.59 -0.42 2.61e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.0 -0.37 5.54e-22 IgG glycosylation; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 9.04 0.34 1.82e-18 Platelet count; BRCA cis rs6738485 0.763 rs11681976 chr2:106841591 C/A cg23109721 chr2:106886537 NA -0.36 -7.89 -0.3 1.36e-14 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA cis rs9549260 0.753 rs9532562 chr13:41153585 A/G cg21288729 chr13:41239152 FOXO1 0.53 8.52 0.32 1.13e-16 Red blood cell count; BRCA cis rs1008375 0.966 rs10939755 chr4:17693755 T/C cg16339924 chr4:17578868 LAP3 0.57 14.23 0.49 4.3e-40 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7188861 0.813 rs7189989 chr16:11442710 G/A cg01510278 chr16:11456238 NA -0.41 -8.72 -0.33 2.34e-17 HDL cholesterol; BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg16145915 chr7:1198662 ZFAND2A -0.46 -9.26 -0.34 3.09e-19 Bronchopulmonary dysplasia; BRCA cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.99 -0.34 2.68e-18 Alzheimer's disease (late onset); BRCA trans rs6089829 0.962 rs6122350 chr20:61664617 A/G cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -8.17 -0.31 1.62e-15 Longevity;Endometriosis; BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg11584989 chr19:19387371 SF4 0.31 7.97 0.3 7.48e-15 Tonsillectomy; BRCA cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg08219700 chr8:58056026 NA 0.56 9.17 0.34 6.42e-19 Developmental language disorder (linguistic errors); BRCA cis rs6952808 0.531 rs3779003 chr7:2184902 C/T cg08027265 chr7:2291960 NA -0.35 -8.47 -0.32 1.7e-16 Bipolar disorder and schizophrenia; BRCA cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg27165867 chr14:105738592 BRF1 -0.36 -8.68 -0.32 3.4e-17 Mean platelet volume;Platelet distribution width; BRCA cis rs1949733 0.656 rs6845969 chr4:8402465 A/T cg11789530 chr4:8429930 ACOX3 0.58 14.62 0.5 5.97e-42 Response to antineoplastic agents; BRCA cis rs10931896 0.531 rs296801 chr2:201142812 C/T cg23649088 chr2:200775458 C2orf69 0.44 9.41 0.35 8.85e-20 Systolic blood pressure; BRCA cis rs12586317 0.547 rs45531432 chr14:35484423 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 9.22e-23 Psoriasis; BRCA cis rs9443645 0.527 rs9352691 chr6:79785607 C/T cg18132916 chr6:79620363 NA -0.4 -8.49 -0.32 1.5e-16 Intelligence (multi-trait analysis); BRCA cis rs7590720 0.851 rs13006614 chr2:216876204 C/T cg12620499 chr2:216877984 MREG 0.79 23.82 0.69 3.1e-90 Alcohol dependence; BRCA cis rs3096299 0.685 rs4329923 chr16:89560178 C/T cg02187348 chr16:89574699 SPG7 0.53 12.64 0.45 7.67e-33 Multiple myeloma (IgH translocation); BRCA cis rs2882667 0.690 rs17031 chr5:138270542 A/T cg04439458 chr5:138467593 SIL1 -0.33 -8.26 -0.31 8.3e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10751667 0.643 rs10902257 chr11:973577 T/C cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 6.69e-19 Alzheimer's disease (late onset); BRCA cis rs7843479 0.930 rs4871903 chr8:21827833 C/T cg17168535 chr8:21777572 XPO7 -0.39 -8.66 -0.32 3.89e-17 Mean corpuscular volume; BRCA cis rs6088590 1.000 rs6120705 chr20:33313740 T/C cg06115741 chr20:33292138 TP53INP2 0.49 10.94 0.4 1.18e-25 Coronary artery disease; BRCA cis rs4665809 0.590 rs7606351 chr2:26292545 A/C cg04944784 chr2:26401820 FAM59B -0.85 -13.38 -0.47 3.72e-36 Gut microbiome composition (summer); BRCA cis rs7666738 0.612 rs6830172 chr4:99093947 G/A cg05340658 chr4:99064831 C4orf37 0.64 14.74 0.5 1.47e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs2996428 0.667 rs16824230 chr1:3766240 A/G cg13057898 chr1:3703894 LRRC47 0.31 8.8 0.33 1.29e-17 Red cell distribution width; BRCA cis rs7975161 1.000 rs7960443 chr12:104645363 G/A cg25273343 chr12:104657179 TXNRD1 -0.52 -11.5 -0.41 5.76e-28 Toenail selenium levels; BRCA cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs2625529 0.775 rs4777484 chr15:72376543 T/C cg16672083 chr15:72433130 SENP8 -0.84 -17.45 -0.57 4.79e-56 Red blood cell count; BRCA cis rs595982 0.559 rs73061643 chr19:49368151 A/G cg15549821 chr19:49342101 PLEKHA4 -0.7 -11.51 -0.41 5.66e-28 Red cell distribution width; BRCA cis rs11690935 0.959 rs10184866 chr2:172608956 T/G cg13550731 chr2:172543902 DYNC1I2 -0.94 -32.36 -0.79 8.91e-137 Schizophrenia; BRCA cis rs13315871 0.929 rs13080398 chr3:58300282 A/G cg20936604 chr3:58311152 NA -0.67 -8.65 -0.32 4.09e-17 Cholesterol, total; BRCA cis rs11971779 0.816 rs11979272 chr7:139074069 C/T cg07862535 chr7:139043722 LUC7L2 0.53 12.91 0.45 4.62e-34 Diisocyanate-induced asthma; BRCA trans rs208520 1.000 rs208536 chr6:66963440 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -14.55 -0.5 1.24e-41 Exhaled nitric oxide output; BRCA cis rs796364 1.000 rs281762 chr2:200799201 C/G cg23649088 chr2:200775458 C2orf69 0.59 8.64 0.32 4.43e-17 Schizophrenia; BRCA cis rs10782582 0.609 rs76260657 chr1:76338017 C/T cg03433033 chr1:76189801 ACADM -0.41 -8.39 -0.32 3.02e-16 Daytime sleep phenotypes; BRCA cis rs977987 0.806 rs4887823 chr16:75433074 T/A cg03315344 chr16:75512273 CHST6 0.52 12.38 0.44 1.02e-31 Dupuytren's disease; BRCA cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg18876405 chr7:65276391 NA -0.55 -12.97 -0.46 2.6e-34 Aortic root size; BRCA cis rs2153535 0.580 rs9505454 chr6:8478532 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.47 0.38 8.84e-24 Motion sickness; BRCA cis rs6582630 0.638 rs4882309 chr12:38448595 A/G cg26384229 chr12:38710491 ALG10B -0.43 -9.99 -0.37 6.19e-22 Drug-induced liver injury (flucloxacillin); BRCA trans rs801193 0.901 rs4273746 chr7:66301111 C/T cg18876405 chr7:65276391 NA -0.62 -14.82 -0.51 6.1e-43 Aortic root size; BRCA cis rs6426558 0.515 rs7543579 chr1:227377699 A/T cg10327440 chr1:227177885 CDC42BPA -0.47 -9.36 -0.35 1.31e-19 Neutrophil percentage of white cells; BRCA cis rs12893668 0.572 rs34000399 chr14:104101417 T/C cg26031613 chr14:104095156 KLC1 -0.53 -9.36 -0.35 1.32e-19 Reticulocyte count; BRCA cis rs17376456 0.569 rs35878747 chr5:93094070 C/A cg25358565 chr5:93447407 FAM172A 0.69 11.87 0.42 1.73e-29 Diabetic retinopathy; BRCA cis rs11252926 0.550 rs11252134 chr10:442599 G/A cg16386425 chr10:429943 DIP2C -0.42 -8.91 -0.33 5.27e-18 Psychosis in Alzheimer's disease; BRCA cis rs8063761 0.689 rs4785763 chr16:90066936 G/T cg08547343 chr16:90038815 CENPBD1;AFG3L1 -0.37 -8.54 -0.32 9.76e-17 Squamous cell carcinoma; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg09436375 chr6:42928200 GNMT -0.29 -10.79 -0.39 4.72e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs559928 0.606 rs17773078 chr11:63906224 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 11.13 0.4 2.02e-26 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs477692 0.905 rs563859 chr10:131417586 T/C cg05714579 chr10:131428358 MGMT 0.57 13.96 0.48 7.94e-39 Response to temozolomide; BRCA cis rs10193935 0.901 rs6544536 chr2:42522042 G/A cg27598129 chr2:42591480 NA -0.6 -10.32 -0.38 3.49e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.621 rs10794351 chr11:946228 C/T cg01483505 chr11:975446 AP2A2 0.33 8.87 0.33 7.11e-18 Alzheimer's disease (late onset); BRCA cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg16414030 chr3:133502952 NA -0.53 -12.36 -0.44 1.3e-31 Iron status biomarkers; BRCA cis rs17092148 1.000 rs6088594 chr20:33343157 A/G cg16810054 chr20:33298113 TP53INP2 0.48 11.01 0.4 6.1e-26 Neuroticism; BRCA cis rs8180040 0.654 rs4682831 chr3:47027138 A/G cg16586182 chr3:47516702 SCAP 0.53 11.9 0.43 1.21e-29 Colorectal cancer; BRCA cis rs6570726 0.935 rs436212 chr6:145849400 G/A cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs2463822 0.925 rs2513075 chr11:62102408 C/T cg06239285 chr11:62104954 ASRGL1 0.67 11.13 0.4 1.92e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA trans rs6952808 0.531 rs3778991 chr7:2172455 G/A cg04565464 chr8:145669602 NFKBIL2 0.42 9.15 0.34 7.49e-19 Bipolar disorder and schizophrenia; BRCA cis rs4906332 1.000 rs12879663 chr14:103874215 A/G cg19000871 chr14:103996768 TRMT61A -0.35 -8.24 -0.31 9.89e-16 Coronary artery disease; BRCA cis rs1865760 0.551 rs9461230 chr6:26019240 G/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.91 0.4 1.53e-25 Height; BRCA cis rs6714710 0.580 rs57681139 chr2:98454473 C/T cg26665480 chr2:98280029 ACTR1B 0.58 13.6 0.47 3.4e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7917772 0.582 rs12779854 chr10:104358474 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.82 -0.48 3.56e-38 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.35e-15 Extrinsic epigenetic age acceleration; BRCA cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg24250549 chr1:154909240 PMVK 0.63 15.87 0.53 4.79e-48 Prostate cancer; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00166722 chr3:10149974 C3orf24 0.67 13.44 0.47 1.83e-36 Alzheimer's disease; BRCA cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg26408565 chr15:76604113 ETFA -0.48 -10.19 -0.37 1.04e-22 Blood metabolite levels; BRCA cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg22974920 chr21:40686053 BRWD1 -0.38 -8.66 -0.32 3.82e-17 Cognitive function; BRCA cis rs11190604 0.943 rs11190568 chr10:102224277 C/T cg07080220 chr10:102295463 HIF1AN 0.54 10.87 0.4 2.27e-25 Palmitoleic acid (16:1n-7) levels; BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg07343612 chr16:622815 PIGQ -0.67 -21.89 -0.65 1.05e-79 Height; BRCA cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg06494592 chr3:125709126 NA -0.53 -8.37 -0.31 3.74e-16 Blood pressure (smoking interaction); BRCA cis rs9462027 0.628 rs9469892 chr6:34769101 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.39e-14 Systemic lupus erythematosus; BRCA cis rs12472274 1.000 rs12472274 chr2:239095422 G/A cg17459225 chr2:239074497 NA 0.63 12.97 0.46 2.69e-34 Phospholipid levels (plasma); BRCA cis rs4800452 0.826 rs28625207 chr18:20746672 A/G cg26136497 chr18:20735537 CABLES1 -0.41 -9.68 -0.36 8.92e-21 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA trans rs11098499 0.954 rs878373 chr4:120237484 A/T cg25214090 chr10:38739885 LOC399744 0.52 11.68 0.42 1.09e-28 Corneal astigmatism; BRCA cis rs780096 0.506 rs1647286 chr2:27714517 A/T cg22903471 chr2:27725779 GCKR -0.39 -9.42 -0.35 8.08e-20 Total body bone mineral density; BRCA trans rs2562456 0.720 rs6511250 chr19:21656046 C/T cg25042112 chr7:64838748 ZNF92 0.42 7.84 0.3 1.87e-14 Pain; BRCA cis rs887829 0.667 rs7577677 chr2:234590616 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.53 -0.32 1.09e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs7412746 0.658 rs11204723 chr1:150731618 T/C cg15448220 chr1:150897856 SETDB1 0.36 8.23 0.31 1.05e-15 Melanoma; BRCA cis rs12989701 1.000 rs13004848 chr2:127887560 C/T cg08168897 chr2:127865431 BIN1 -0.79 -13.38 -0.47 3.5e-36 Alzheimer's disease (late onset); BRCA cis rs2204008 0.659 rs4002655 chr12:38169881 T/G cg13010199 chr12:38710504 ALG10B 0.44 8.93 0.33 4.46e-18 Bladder cancer; BRCA cis rs2304069 0.954 rs2276983 chr5:149424966 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.71 14.49 0.5 2.29e-41 HIV-1 control; BRCA cis rs7647973 0.925 rs7429661 chr3:49228800 G/A cg07636037 chr3:49044803 WDR6 0.66 13.19 0.46 2.6e-35 Menarche (age at onset); BRCA cis rs6960043 0.738 rs10950549 chr7:15057829 G/A cg19272540 chr7:15055459 NA 0.22 7.81 0.3 2.29e-14 Type 2 diabetes; BRCA cis rs10463316 0.928 rs10060441 chr5:150750006 A/G cg03212797 chr5:150827313 SLC36A1 -0.41 -7.98 -0.3 6.63e-15 Metabolite levels (Pyroglutamine); BRCA cis rs6977660 0.714 rs10231980 chr7:19789383 C/G cg05791153 chr7:19748676 TWISTNB 0.65 11.71 0.42 7.81e-29 Thyroid stimulating hormone; BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.61 0.61 2.24e-67 Platelet count; BRCA trans rs8073060 0.586 rs2428464 chr17:34021994 C/G cg19694781 chr19:47549865 TMEM160 -1.07 -21.69 -0.65 1.28e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs3780378 0.875 rs4372063 chr9:5003338 C/T cg02405213 chr9:5042618 JAK2 -0.41 -7.85 -0.3 1.75e-14 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs7246657 0.606 rs2972439 chr19:38212581 T/C cg23950597 chr19:37808831 NA 0.5 8.62 0.32 5.24e-17 Coronary artery calcification; BRCA trans rs3857536 0.740 rs7756519 chr6:66892275 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs17401966 0.838 rs4846206 chr1:10310258 G/C cg03954927 chr1:10346856 KIF1B 0.43 13.5 0.47 9.75e-37 Hepatocellular carcinoma; BRCA cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg01448562 chr3:133502909 NA -0.64 -15.29 -0.52 3.21e-45 Iron status biomarkers; BRCA cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7737355 0.812 rs10054168 chr5:130788698 C/T cg06307176 chr5:131281290 NA -0.48 -10.41 -0.38 1.52e-23 Life satisfaction; BRCA cis rs875971 0.862 rs880166 chr7:65670762 T/C cg18876405 chr7:65276391 NA -0.51 -11.6 -0.42 2.26e-28 Aortic root size; BRCA cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg04450456 chr4:17643702 FAM184B 0.31 8.99 0.34 2.76e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9581857 0.519 rs9581880 chr13:28105850 C/A cg22138327 chr13:27999177 GTF3A 0.56 7.97 0.3 7.37e-15 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); BRCA cis rs67311347 0.869 rs9832311 chr3:40381322 A/T cg09455208 chr3:40491958 NA 0.4 9.5 0.35 4.23e-20 Renal cell carcinoma; BRCA cis rs1707322 1.000 rs10789485 chr1:46407308 C/T cg06784218 chr1:46089804 CCDC17 0.5 11.73 0.42 6.65e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs270601 0.770 rs932019 chr5:131599370 T/C cg18758796 chr5:131593413 PDLIM4 0.4 10.11 0.37 2.18e-22 Acylcarnitine levels; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg03354898 chr7:1950403 MAD1L1 0.45 9.17 0.34 6.54e-19 Bipolar disorder and schizophrenia; BRCA cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg08564027 chr20:61660810 NA 0.84 23.09 0.67 3.27e-86 Prostate cancer (SNP x SNP interaction); BRCA cis rs68170813 0.599 rs12533516 chr7:106937135 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.76 -0.33 1.8e-17 Coronary artery disease; BRCA cis rs8062405 0.723 rs113208333 chr16:28606160 G/T cg16576597 chr16:28551801 NUPR1 0.32 8.58 0.32 7.04e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs7824557 1.000 rs2736371 chr8:11105529 A/G cg08975724 chr8:8085496 FLJ10661 -0.45 -8.71 -0.33 2.64e-17 Retinal vascular caliber; BRCA cis rs6088580 0.634 rs6141465 chr20:32967314 T/C cg08999081 chr20:33150536 PIGU -0.45 -12.43 -0.44 6.29e-32 Glomerular filtration rate (creatinine); BRCA cis rs1215050 0.818 rs165238 chr4:98712138 G/T cg05340658 chr4:99064831 C4orf37 0.43 9.76 0.36 4.5e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs17818399 1.000 rs62136864 chr2:46829124 G/A cg02822958 chr2:46747628 ATP6V1E2 0.52 10.33 0.38 2.97e-23 Height; BRCA cis rs208520 0.690 rs3843513 chr6:66836797 A/G cg07460842 chr6:66804631 NA -1.02 -20.08 -0.62 6.48e-70 Exhaled nitric oxide output; BRCA cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg04034577 chr2:241836375 C2orf54 -0.56 -13.99 -0.48 5.17e-39 Urinary metabolites; BRCA trans rs1941687 0.510 rs1452649 chr18:31410858 A/G cg15819921 chr19:927150 ARID3A -0.41 -8.11 -0.31 2.57e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs9300255 0.602 rs2695476 chr12:123694206 T/C cg00376283 chr12:123451042 ABCB9 0.51 9.97 0.37 7.2e-22 Neutrophil percentage of white cells; BRCA cis rs1153858 1.000 rs1820518 chr15:45694579 C/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.42 0.41 1.25e-27 Homoarginine levels; BRCA cis rs943466 1.000 rs6933568 chr6:33751261 G/A cg25922239 chr6:33757077 LEMD2 -0.38 -7.88 -0.3 1.38e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg23262073 chr20:60523788 NA 0.57 13.8 0.48 4.17e-38 Obesity-related traits; BRCA trans rs17742757 0.522 rs899364 chr8:11329544 G/T cg06636001 chr8:8085503 FLJ10661 -0.43 -8.17 -0.31 1.62e-15 Response to efavirenz-containing treatment in HIV 1 infection (virologic failure); BRCA cis rs6484504 0.512 rs2774402 chr11:31312897 G/C cg06552810 chr11:31128660 NA 0.39 8.95 0.33 3.89e-18 Red blood cell count; BRCA cis rs4148883 0.629 rs2602899 chr4:100010128 C/T cg12011299 chr4:100065546 ADH4 0.42 10.89 0.4 1.89e-25 Alcohol dependence; BRCA cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg07395648 chr5:131743802 NA -0.44 -10.28 -0.38 4.8e-23 Breast cancer;Mosquito bite size; BRCA trans rs629535 0.862 rs598548 chr8:70032438 C/T cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs4319547 0.656 rs10161534 chr12:122873864 T/C cg05707623 chr12:122985044 ZCCHC8 -0.42 -8.61 -0.32 5.71e-17 Body mass index; BRCA cis rs2463822 1.000 rs2463822 chr11:62103420 T/C cg06239285 chr11:62104954 ASRGL1 0.62 9.19 0.34 5.35e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg03929089 chr4:120376271 NA 0.65 12.8 0.45 1.46e-33 Coronary artery disease; BRCA cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg12386194 chr3:101231763 SENP7 0.62 11.38 0.41 1.88e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs4975616 0.807 rs28379291 chr5:1313701 A/G cg06550200 chr5:1325588 CLPTM1L 0.56 11.26 0.41 6.1e-27 Lung cancer; BRCA cis rs79839061 0.656 rs11726508 chr4:888937 C/T cg07828340 chr4:882639 GAK 0.79 11.41 0.41 1.47e-27 Intelligence (multi-trait analysis); BRCA cis rs4588572 0.643 rs1560196 chr5:77701982 G/C cg11547950 chr5:77652471 NA 0.46 8.37 0.31 3.72e-16 Triglycerides; BRCA trans rs4819388 0.751 rs12482807 chr21:45642363 G/A cg17383793 chr5:52405638 MOCS2 -0.48 -10.76 -0.39 6.06e-25 Celiac disease; BRCA cis rs4819052 0.851 rs8131143 chr21:46671646 C/G cg11663144 chr21:46675770 NA 0.61 14.29 0.49 2.17e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg27286337 chr10:134555280 INPP5A 0.8 13.09 0.46 7.19e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1113500 0.933 rs11185250 chr1:108616417 A/G cg06207961 chr1:108661230 NA 0.45 11.09 0.4 2.99e-26 Growth-regulated protein alpha levels; BRCA cis rs7918232 0.891 rs10443987 chr10:27375377 A/T cg14240646 chr10:27532245 ACBD5 -0.69 -10.77 -0.39 5.59e-25 Breast cancer; BRCA cis rs6714710 0.603 rs34373359 chr2:98442202 G/A cg26665480 chr2:98280029 ACTR1B 0.6 13.82 0.48 3.49e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7582180 0.606 rs10174145 chr2:100932488 T/C cg14675211 chr2:100938903 LONRF2 0.48 11.07 0.4 3.7e-26 Intelligence (multi-trait analysis); BRCA cis rs1595825 0.945 rs73056890 chr2:198831260 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.13 -0.31 2.26e-15 Ulcerative colitis; BRCA cis rs9381040 0.701 rs4711658 chr6:41162891 C/T cg03526776 chr6:41159608 TREML2 -0.4 -8.25 -0.31 8.99e-16 Alzheimer's disease (late onset); BRCA cis rs9355610 0.609 rs9366076 chr6:167373708 C/T cg23791538 chr6:167370224 RNASET2 0.44 8.7 0.33 2.81e-17 Graves' disease; BRCA trans rs4650994 1.000 rs35810840 chr1:178522642 G/A cg05059571 chr16:84539110 KIAA1609 -0.42 -9.5 -0.35 3.97e-20 HDL cholesterol levels;HDL cholesterol; BRCA trans rs801193 1.000 rs4279493 chr7:66226620 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.35 0.31 4.08e-16 Aortic root size; BRCA cis rs6831352 0.918 rs2602894 chr4:100045647 A/G cg12011299 chr4:100065546 ADH4 0.5 11.72 0.42 7.29e-29 Alcohol dependence; BRCA cis rs35146811 0.586 rs10267212 chr7:99595422 T/C cg22906224 chr7:99728672 NA 0.43 8.19 0.31 1.37e-15 Coronary artery disease; BRCA trans rs61931739 0.517 rs1197562 chr12:34122037 G/A cg13010199 chr12:38710504 ALG10B 0.39 8.05 0.3 3.99e-15 Morning vs. evening chronotype; BRCA cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA trans rs9467711 0.606 rs2235251 chr6:26431982 C/T cg01620082 chr3:125678407 NA -0.64 -8.56 -0.32 8.69e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs6582630 0.537 rs1949611 chr12:38373092 C/T cg13010199 chr12:38710504 ALG10B -0.38 -8.24 -0.31 9.75e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs16973500 0.732 rs1549292 chr16:71983664 A/C cg00732059 chr16:71740210 PHLPP2 -0.59 -9.8 -0.36 3.2e-21 Response to anti-TNF therapy in rheumatoid arthritis;Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs875971 0.825 rs6951503 chr7:65718936 T/G cg18876405 chr7:65276391 NA -0.52 -11.48 -0.41 7.03e-28 Aortic root size; BRCA cis rs6582630 0.537 rs1851124 chr12:38516404 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.72 0.57 1.89e-57 Drug-induced liver injury (flucloxacillin); BRCA trans rs7939886 0.920 rs11231821 chr11:55777052 C/G cg15704280 chr7:45808275 SEPT13 0.62 7.91 0.3 1.11e-14 Myopia (pathological); BRCA cis rs6138458 0.701 rs6138474 chr20:25012427 T/A cg26195577 chr20:24973756 C20orf3 0.62 14.79 0.51 8.31e-43 Blood protein levels; BRCA cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg22974920 chr21:40686053 BRWD1 -0.35 -7.83 -0.3 1.98e-14 Menarche (age at onset); BRCA trans rs11098499 0.863 rs3822192 chr4:120445720 A/C cg25214090 chr10:38739885 LOC399744 0.55 11.92 0.43 1.04e-29 Corneal astigmatism; BRCA cis rs1552244 1.000 rs722509 chr3:10102377 T/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.6 -0.45 1.15e-32 Alzheimer's disease; BRCA cis rs826838 1.000 rs860400 chr12:39081279 A/G cg26384229 chr12:38710491 ALG10B -0.63 -16.39 -0.54 1.15e-50 Heart rate; BRCA cis rs56399783 0.901 rs73049327 chr7:2795544 T/G cg23627948 chr7:2760692 NA 0.48 7.81 0.3 2.4e-14 Childhood ear infection; BRCA cis rs6121246 0.633 rs6060986 chr20:30426297 G/A cg13852791 chr20:30311386 BCL2L1 0.88 20.17 0.62 2.32e-70 Mean corpuscular hemoglobin; BRCA cis rs3733585 0.699 rs7663097 chr4:9966791 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.37 -0.38 2.18e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10911251 0.528 rs10911263 chr1:183115018 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.36 0.54 1.69e-50 Colorectal cancer; BRCA cis rs10493773 0.577 rs17398175 chr1:86074710 A/G cg17807903 chr1:86174739 ZNHIT6 -0.43 -8.15 -0.31 1.96e-15 Urate levels in overweight individuals; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg14004847 chr7:1930337 MAD1L1 -0.45 -9.13 -0.34 8.73e-19 Bipolar disorder and schizophrenia; BRCA cis rs8180040 0.726 rs4234465 chr3:47026885 C/G cg16586182 chr3:47516702 SCAP -0.53 -11.83 -0.42 2.45e-29 Colorectal cancer; BRCA cis rs4689592 0.546 rs10937784 chr4:7060935 G/C cg02503808 chr4:7069936 GRPEL1 0.78 18.24 0.59 3.58e-60 Monocyte percentage of white cells; BRCA cis rs2346177 0.638 rs34186951 chr2:46657659 A/G cg26688816 chr2:46740690 ATP6V1E2 -0.39 -8.56 -0.32 8.6e-17 HDL cholesterol; BRCA cis rs6088813 1.000 rs735531 chr20:33947730 T/C cg14752227 chr20:34000481 UQCC -0.43 -9.16 -0.34 6.86e-19 Height; BRCA cis rs72781680 0.898 rs7569424 chr2:24036222 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.01 0.34 2.37e-18 Lymphocyte counts; BRCA cis rs34779708 0.931 rs7084196 chr10:35367161 T/C cg03585969 chr10:35415529 CREM 0.5 10.51 0.38 6.02e-24 Inflammatory bowel disease;Crohn's disease; BRCA trans rs11976180 1.000 rs2951308 chr7:143767149 A/C cg00397059 chr6:132031294 CTAGE9;ENPP3 0.42 7.93 0.3 9.96e-15 Obesity-related traits; BRCA cis rs3733585 0.673 rs4292333 chr4:9953871 G/A cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.53e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2239547 0.563 rs9876403 chr3:52916916 C/T cg18404041 chr3:52824283 ITIH1 -0.31 -7.88 -0.3 1.43e-14 Schizophrenia; BRCA trans rs11098499 0.909 rs1546504 chr4:120241179 C/T cg25214090 chr10:38739885 LOC399744 0.52 11.79 0.42 3.78e-29 Corneal astigmatism; BRCA cis rs1865760 0.713 rs9461229 chr6:25992279 G/T cg16482183 chr6:26056742 HIST1H1C 0.5 10.69 0.39 1.16e-24 Height; BRCA cis rs2404602 0.716 rs17460201 chr15:76673627 C/T cg22467129 chr15:76604101 ETFA 0.48 10.62 0.39 2.3e-24 Blood metabolite levels; BRCA cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg11657440 chr19:46296263 DMWD 0.71 19.19 0.6 3.74e-65 Coronary artery disease; BRCA cis rs9300255 0.602 rs1727313 chr12:123640853 C/G cg00376283 chr12:123451042 ABCB9 0.54 11.0 0.4 6.76e-26 Neutrophil percentage of white cells; BRCA cis rs9291683 0.632 rs10939669 chr4:10045827 A/G cg00071950 chr4:10020882 SLC2A9 0.64 15.64 0.53 6.38e-47 Bone mineral density; BRCA cis rs8032158 1.000 rs10851599 chr15:56154064 T/G cg02198044 chr15:56286336 NEDD4 -0.37 -8.84 -0.33 8.98e-18 Keloid; BRCA cis rs483180 0.512 rs598685 chr1:120215269 G/A cg19096424 chr1:120255104 PHGDH 0.44 9.59 0.35 1.93e-20 Macular telangiectasia type 2; BRCA cis rs61931739 0.534 rs11052979 chr12:34035774 G/T cg06521331 chr12:34319734 NA -0.62 -11.19 -0.4 1.1e-26 Morning vs. evening chronotype; BRCA cis rs7737355 0.812 rs6896132 chr5:130773561 C/G cg06307176 chr5:131281290 NA 0.47 10.19 0.37 1.05e-22 Life satisfaction; BRCA cis rs2742234 0.955 rs2503841 chr10:43675721 C/T cg02780029 chr10:43622663 RET -0.39 -9.87 -0.36 1.81e-21 Hirschsprung disease; BRCA cis rs6840360 0.593 rs4696107 chr4:152606823 G/A cg22705602 chr4:152727874 NA -0.38 -10.3 -0.38 4.15e-23 Intelligence (multi-trait analysis); BRCA cis rs6484504 0.576 rs286649 chr11:31230468 C/T cg14844989 chr11:31128820 NA -0.45 -9.65 -0.36 1.14e-20 Red blood cell count; BRCA trans rs60843830 0.661 rs7561648 chr2:105171 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.49 9.43 0.35 7.28e-20 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7615952 0.641 rs6805074 chr3:125772274 T/A cg04553112 chr3:125709451 NA -0.56 -8.47 -0.32 1.68e-16 Blood pressure (smoking interaction); BRCA cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg03684893 chr10:554711 DIP2C -0.4 -9.59 -0.35 2.01e-20 Psychosis in Alzheimer's disease; BRCA cis rs10751667 0.666 rs10902247 chr11:953686 G/A cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs2153535 0.580 rs7748455 chr6:8453625 C/T cg23788917 chr6:8435910 SLC35B3 0.47 10.18 0.37 1.19e-22 Motion sickness; BRCA cis rs4363385 0.818 rs3181787 chr1:153004809 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.22 -0.34 4.35e-19 Inflammatory skin disease; BRCA trans rs6598955 0.671 rs12085416 chr1:26627835 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.64 -15.27 -0.52 4.23e-45 Obesity-related traits; BRCA cis rs2288912 0.808 rs35670684 chr19:45455985 A/C cg09555818 chr19:45449301 APOC2 0.47 12.07 0.43 2.28e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg15212455 chr7:39170539 POU6F2 0.43 9.55 0.35 2.79e-20 IgG glycosylation; BRCA cis rs6089584 0.566 rs7274240 chr20:60622004 C/T cg06108461 chr20:60628389 TAF4 -0.75 -15.63 -0.53 7.54e-47 Body mass index; BRCA cis rs61990749 0.597 rs1549119 chr14:78219812 A/T cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.97 0.3 7.44e-15 Fibroblast growth factor basic levels; BRCA cis rs17741873 0.836 rs4745723 chr10:75603338 T/C cg07699608 chr10:75541558 CHCHD1 0.53 8.55 0.32 8.84e-17 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs1552244 0.626 rs2886396 chr3:10037670 C/T cg10729496 chr3:10149963 C3orf24 0.41 7.88 0.3 1.44e-14 Alzheimer's disease; BRCA cis rs60843830 1.000 rs57542652 chr2:228088 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.78 17.63 0.57 5.22e-57 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs992157 0.798 rs7557709 chr2:219167529 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.54 11.7 0.42 9.11e-29 Colorectal cancer; BRCA cis rs5750830 0.649 rs4337572 chr22:39800704 C/G cg05872129 chr22:39784769 NA -0.55 -11.99 -0.43 5.27e-30 Intelligence (multi-trait analysis); BRCA cis rs10267417 0.603 rs79323924 chr7:19924321 T/G cg05791153 chr7:19748676 TWISTNB 0.44 8.16 0.31 1.8e-15 Night sleep phenotypes; BRCA cis rs7586879 0.616 rs10203386 chr2:25136866 T/A cg01884057 chr2:25150051 NA 0.3 8.02 0.3 4.91e-15 Body mass index; BRCA cis rs1003719 0.646 rs2032063 chr21:38576657 A/T cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs6534441 0.727 rs77899971 chr4:125419177 C/G cg21609808 chr4:125404261 NA 0.35 7.88 0.3 1.4e-14 Major depressive disorder; BRCA cis rs9527 0.590 rs2066322 chr10:104909339 T/G cg04362960 chr10:104952993 NT5C2 0.45 10.28 0.38 4.8e-23 Arsenic metabolism; BRCA cis rs6540559 0.673 rs17015218 chr1:209967915 A/G cg22029157 chr1:209979665 IRF6 0.55 11.41 0.41 1.39e-27 Cleft lip with or without cleft palate; BRCA cis rs727479 0.523 rs8034835 chr15:51512664 A/G cg19946085 chr15:51559439 CYP19A1 -0.3 -8.54 -0.32 1.02e-16 Estradiol levels; BRCA cis rs6547741 1.000 rs1080060 chr2:27768808 T/A cg27432699 chr2:27873401 GPN1 0.47 9.93 0.37 1.09e-21 Oral cavity cancer; BRCA cis rs752010 0.695 rs10789408 chr1:42106579 T/C cg06885757 chr1:42089581 HIVEP3 0.23 8.35 0.31 4.34e-16 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs2282526 0.615 rs162377 chr21:44926001 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.41 8.05 0.3 4.13e-15 Mean corpuscular hemoglobin; BRCA cis rs12618769 0.597 rs3754880 chr2:99132215 G/C cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.45e-16 Bipolar disorder; BRCA cis rs6782228 0.606 rs2811489 chr3:128337371 A/G cg16766828 chr3:128327626 NA 0.42 9.35 0.35 1.41e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs3824867 0.879 rs10742806 chr11:47456226 T/A cg20307385 chr11:47447363 PSMC3 0.51 11.55 0.42 3.81e-28 Mean corpuscular hemoglobin; BRCA cis rs10992471 0.528 rs10514815 chr9:95256695 C/A cg14631576 chr9:95140430 CENPP -0.34 -8.55 -0.32 8.74e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7772486 0.875 rs2814874 chr6:146305895 C/T cg23711669 chr6:146136114 FBXO30 0.74 16.67 0.55 4.5e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs1538970 0.924 rs12097497 chr1:45880669 C/T cg05343316 chr1:45956843 TESK2 0.64 12.89 0.45 5.63e-34 Platelet count; BRCA cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg18876405 chr7:65276391 NA -0.63 -15.65 -0.53 5.63e-47 Aortic root size; BRCA cis rs35146811 0.735 rs6465766 chr7:99785671 A/G cg13334819 chr7:99746414 C7orf59 -0.35 -8.22 -0.31 1.11e-15 Coronary artery disease; BRCA cis rs2180341 0.782 rs4487601 chr6:127723521 A/G cg27446573 chr6:127587934 RNF146 0.68 15.54 0.52 1.94e-46 Breast cancer; BRCA cis rs12986413 1.000 rs12986413 chr19:2170954 A/T cg09261902 chr19:2140048 AP3D1 -0.36 -9.56 -0.35 2.45e-20 Height; BRCA cis rs798554 0.836 rs798490 chr7:2801542 C/T cg04166393 chr7:2884313 GNA12 0.52 9.97 0.37 7.38e-22 Height; BRCA cis rs9859260 0.744 rs492349 chr3:195784192 G/A cg03462622 chr3:195777018 TFRC -0.38 -8.63 -0.32 4.83e-17 Mean corpuscular volume; BRCA cis rs17376456 0.877 rs34595581 chr5:93369422 G/A cg21475434 chr5:93447410 FAM172A 0.67 8.44 0.32 2.16e-16 Diabetic retinopathy; BRCA cis rs12971120 0.685 rs34780792 chr18:72173278 G/A cg26446133 chr18:72167187 CNDP2 -0.77 -13.69 -0.48 1.42e-37 Refractive error; BRCA cis rs4727027 0.933 rs6961605 chr7:148870108 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.07 0.4 3.39e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.61 13.69 0.48 1.37e-37 Eosinophil percentage of white cells; BRCA cis rs4363385 0.747 rs10494285 chr1:152982285 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs6088580 0.634 rs2424992 chr20:33012060 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.68 0.32 3.35e-17 Glomerular filtration rate (creatinine); BRCA cis rs10782582 0.569 rs2131557 chr1:76388589 A/C cg03433033 chr1:76189801 ACADM 0.4 8.48 0.32 1.55e-16 Daytime sleep phenotypes; BRCA cis rs3008870 0.701 rs2815358 chr1:67493778 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.88 0.48 1.69e-38 Lymphocyte percentage of white cells; BRCA cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.78 0.42 3.9e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00149659 chr3:10157352 C3orf10 0.84 14.73 0.5 1.63e-42 Alzheimer's disease; BRCA cis rs12493885 0.818 rs10935972 chr3:153774029 G/A cg17054900 chr3:154042577 DHX36 -0.5 -8.64 -0.32 4.41e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg04450456 chr4:17643702 FAM184B 0.39 11.59 0.42 2.46e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg06212747 chr3:49208901 KLHDC8B 0.49 10.23 0.38 7.29e-23 Parkinson's disease; BRCA cis rs6963495 0.818 rs6961233 chr7:105150469 C/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.07e-19 Bipolar disorder (body mass index interaction); BRCA cis rs4363385 0.747 rs11205149 chr1:152958840 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -8.19 -0.31 1.38e-15 Inflammatory skin disease; BRCA cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg06481639 chr22:41940642 POLR3H 0.54 8.41 0.32 2.68e-16 Vitiligo; BRCA cis rs1215050 0.782 rs6532693 chr4:98655815 T/C cg05340658 chr4:99064831 C4orf37 -0.44 -9.97 -0.37 7.4e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs782590 0.721 rs782641 chr2:55929294 C/T cg18811423 chr2:55921094 PNPT1 0.77 26.01 0.72 2.74e-102 Metabolic syndrome; BRCA cis rs763014 1.000 rs7205409 chr16:642610 A/G cg00908189 chr16:619842 PIGQ 0.66 16.49 0.55 3.73e-51 Height; BRCA cis rs867371 1.000 rs1392976 chr15:82446175 A/G cg00614314 chr15:82944287 LOC80154 -0.43 -9.16 -0.34 6.9e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs1005277 0.579 rs176880 chr10:38401417 C/G cg25427524 chr10:38739819 LOC399744 0.69 16.91 0.56 2.7e-53 Extrinsic epigenetic age acceleration; BRCA cis rs34779708 0.966 rs4934536 chr10:35441169 A/G cg03585969 chr10:35415529 CREM 0.57 11.63 0.42 1.63e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs35306767 0.716 rs34487581 chr10:897201 G/A cg20503657 chr10:835505 NA 1.31 21.98 0.66 3.63e-80 Eosinophil percentage of granulocytes; BRCA cis rs4237845 0.773 rs6650218 chr12:58289078 T/A cg02175503 chr12:58329896 NA 0.56 13.34 0.47 5.6e-36 Intelligence (multi-trait analysis); BRCA cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.23 7.96 0.3 8.14e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs9304742 0.962 rs12461778 chr19:53454963 T/A cg24044776 chr19:53454761 ZNF816A -0.41 -9.31 -0.35 2.09e-19 Psoriasis; BRCA cis rs7618501 0.633 rs2883057 chr3:49998282 C/T cg24308560 chr3:49941425 MST1R -0.4 -8.59 -0.32 6.45e-17 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs6083809 chr20:25329309 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.31 -0.31 5.95e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.580 rs2183112 chr6:8528212 G/A cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.59e-19 Motion sickness; BRCA cis rs7267979 0.718 rs2983489 chr20:25244120 C/A cg08601574 chr20:25228251 PYGB 0.34 8.16 0.31 1.74e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7593730 0.636 rs7583157 chr2:161114552 A/G cg22609984 chr2:161126801 NA 0.43 9.2 0.34 4.96e-19 Type 2 diabetes; BRCA cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs7100689 0.622 rs2342816 chr10:82086546 G/A cg00277334 chr10:82204260 NA -0.43 -8.48 -0.32 1.53e-16 Post bronchodilator FEV1; BRCA cis rs1691799 0.867 rs1168311 chr12:66725912 A/C cg16791601 chr12:66731901 HELB 0.63 17.08 0.56 3.49e-54 White blood cell count (basophil); BRCA cis rs2836974 0.568 rs2183573 chr21:40574305 A/G cg22974920 chr21:40686053 BRWD1 -0.37 -8.37 -0.31 3.68e-16 Cognitive function; BRCA cis rs12477438 0.748 rs7558239 chr2:99640581 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -11.79 -0.42 3.5e-29 Alzheimer's disease; BRCA cis rs514406 0.698 rs567880 chr1:53348564 T/G cg25767906 chr1:53392781 SCP2 -0.46 -10.27 -0.38 5.21e-23 Monocyte count; BRCA trans rs9858542 0.953 rs9818590 chr3:49525096 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.48 -0.35 4.76e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs11723261 0.582 rs6599293 chr4:133027 A/G cg12746427 chr4:53362 ZNF718;ZNF595 0.34 7.9 0.3 1.18e-14 Immune response to smallpox vaccine (IL-6); BRCA cis rs1800469 1.000 rs1549933 chr19:41871142 A/G cg09537434 chr19:41945824 ATP5SL -0.6 -10.96 -0.4 1e-25 Colorectal cancer; BRCA cis rs877282 0.945 rs11253390 chr10:788678 A/G cg17470449 chr10:769945 NA 0.51 8.63 0.32 4.87e-17 Uric acid levels; BRCA cis rs6952808 0.582 rs871925 chr7:2047875 G/A cg04267008 chr7:1944627 MAD1L1 0.4 8.88 0.33 6.69e-18 Bipolar disorder and schizophrenia; BRCA trans rs11098499 0.863 rs3822191 chr4:120428101 A/T cg25214090 chr10:38739885 LOC399744 0.55 11.82 0.42 2.68e-29 Corneal astigmatism; BRCA cis rs6733011 0.542 rs6542860 chr2:99679376 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.35 -7.88 -0.3 1.4e-14 Bipolar disorder; BRCA cis rs11105298 0.891 rs10858889 chr12:89902604 G/A cg00757033 chr12:89920650 WDR51B 0.54 11.13 0.4 1.99e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs11098499 0.865 rs28753180 chr4:120405367 A/T cg25214090 chr10:38739885 LOC399744 0.53 12.03 0.43 3.51e-30 Corneal astigmatism; BRCA cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg05347473 chr6:146136440 FBXO30 0.39 7.87 0.3 1.54e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs1349757 chr4:99058763 C/G cg05340658 chr4:99064831 C4orf37 0.67 16.49 0.55 3.48e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs853679 0.517 rs9393886 chr6:28050039 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Depression; BRCA cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg20607798 chr8:58055168 NA 0.48 8.4 0.32 2.81e-16 Developmental language disorder (linguistic errors); BRCA cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.72 11.46 0.41 8.82e-28 Mean platelet volume; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg08888203 chr3:10149979 C3orf24 0.67 14.07 0.49 2.42e-39 Alzheimer's disease; BRCA cis rs3740540 0.530 rs10794163 chr10:126291398 A/G cg04949429 chr10:126290192 LHPP 0.43 12.01 0.43 4.06e-30 Obesity-related traits;Acute lymphoblastic leukemia (childhood); BRCA cis rs9858542 1.000 rs11718165 chr3:49696797 A/G cg03060546 chr3:49711283 APEH -0.58 -11.57 -0.42 3.06e-28 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs870825 0.616 rs7659101 chr4:185632158 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.25 0.56 4.74e-55 Blood protein levels; BRCA cis rs72781680 0.611 rs2111884 chr2:24289472 A/T cg20701182 chr2:24300061 SF3B14 0.71 13.2 0.46 2.28e-35 Lymphocyte counts; BRCA cis rs6543140 0.964 rs6543136 chr2:103065547 G/A cg04239558 chr2:103089729 SLC9A4 0.34 9.62 0.36 1.47e-20 Blood protein levels; BRCA cis rs2625529 0.668 rs34189331 chr15:72404573 A/T cg16672083 chr15:72433130 SENP8 -0.77 -16.61 -0.55 9.22e-52 Red blood cell count; BRCA cis rs7000551 0.715 rs7828610 chr8:22307326 C/T cg12081754 chr8:22256438 SLC39A14 0.39 7.92 0.3 1.07e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg06494592 chr3:125709126 NA -0.53 -8.21 -0.31 1.22e-15 Blood pressure (smoking interaction); BRCA cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.41 -0.44 8.14e-32 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg00166722 chr3:10149974 C3orf24 0.57 11.15 0.4 1.61e-26 Alzheimer's disease; BRCA cis rs782590 0.935 rs782649 chr2:55860308 T/C cg18811423 chr2:55921094 PNPT1 0.71 22.76 0.67 2.07e-84 Metabolic syndrome; BRCA cis rs3733585 0.673 rs7377578 chr4:9952775 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.28 -0.38 5.01e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.29 -0.41 4.62e-27 Gut microbiome composition (summer); BRCA cis rs295140 0.507 rs4673814 chr2:201108133 G/A cg23649088 chr2:200775458 C2orf69 -0.4 -8.36 -0.31 4.03e-16 QT interval; BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.48 9.54 0.35 2.85e-20 Lymphocyte counts; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg02951883 chr7:2050386 MAD1L1 -0.4 -8.82 -0.33 1.06e-17 Bipolar disorder and schizophrenia; BRCA cis rs2629540 0.889 rs10901815 chr10:126435598 G/A cg08799069 chr10:126477246 METTL10 -0.53 -11.66 -0.42 1.29e-28 Cocaine dependence; BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg16606324 chr3:10149918 C3orf24 0.57 10.22 0.37 8.35e-23 Alzheimer's disease; BRCA cis rs4975616 0.869 rs465498 chr5:1325803 A/G cg07493874 chr5:1342172 CLPTM1L -0.49 -14.12 -0.49 1.35e-39 Lung cancer; BRCA cis rs12216125 0.801 rs56107510 chr6:25987436 C/A cg16482183 chr6:26056742 HIST1H1C 0.6 12.16 0.43 9.47e-31 Iron status biomarkers; BRCA cis rs10128251 0.743 rs2386636 chr10:5712087 G/T cg24097872 chr10:5724021 NA 0.44 9.95 0.37 9.16e-22 Childhood ear infection; BRCA cis rs17095355 0.901 rs17126938 chr10:111761351 T/C cg00817464 chr10:111662876 XPNPEP1 -0.44 -10.06 -0.37 3.35e-22 Biliary atresia; BRCA cis rs7772486 0.754 rs4895682 chr6:146062861 G/A cg05347473 chr6:146136440 FBXO30 -0.42 -8.42 -0.32 2.5e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs6545883 1.000 rs6545883 chr2:61772257 A/G cg15711740 chr2:61764176 XPO1 -0.51 -12.98 -0.46 2.34e-34 Tuberculosis; BRCA cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg22800045 chr5:56110881 MAP3K1 0.65 12.18 0.43 7.48e-31 Initial pursuit acceleration; BRCA cis rs7395581 0.797 rs10742801 chr11:47342220 A/C cg25783544 chr11:47291846 MADD 0.4 9.02 0.34 2.11e-18 HDL cholesterol; BRCA cis rs2816062 0.813 rs2816044 chr1:18892826 A/G cg18795169 chr1:18902165 NA -0.93 -27.62 -0.74 4.26e-111 Urate levels in lean individuals; BRCA trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg03929089 chr4:120376271 NA -0.66 -12.93 -0.46 3.9e-34 Coronary artery disease; BRCA cis rs10992471 0.756 rs3758229 chr9:95078852 G/T cg14631576 chr9:95140430 CENPP -0.37 -8.92 -0.33 4.99e-18 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs9287719 0.649 rs6714787 chr2:10729032 C/T cg00105475 chr2:10696890 NA 0.41 9.18 0.34 5.88e-19 Prostate cancer; BRCA cis rs67981189 0.858 rs2526862 chr14:71409614 T/C cg15816911 chr14:71606274 NA -0.37 -8.18 -0.31 1.52e-15 Schizophrenia; BRCA cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg08392591 chr16:89556376 ANKRD11 0.38 9.15 0.34 7.84e-19 Multiple myeloma (IgH translocation); BRCA cis rs2731664 0.792 rs2731662 chr5:176872494 C/T cg23176889 chr5:176863531 GRK6 0.63 17.73 0.57 1.66e-57 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26314531 chr2:26401878 FAM59B -0.78 -12.15 -0.43 1.06e-30 Gut microbiome composition (summer); BRCA trans rs6952808 0.689 rs871924 chr7:2047845 A/G cg04565464 chr8:145669602 NFKBIL2 0.33 8.03 0.3 4.84e-15 Bipolar disorder and schizophrenia; BRCA trans rs1941687 0.563 rs9953034 chr18:31335294 A/G cg27147174 chr7:100797783 AP1S1 -0.43 -8.38 -0.31 3.42e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs9790314 0.779 rs1599374 chr3:160891727 G/A cg03342759 chr3:160939853 NMD3 -0.57 -11.29 -0.41 4.44e-27 Morning vs. evening chronotype; BRCA cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs1401999 1.000 rs1533684 chr3:183635815 A/G cg01324343 chr3:183735012 ABCC5 0.85 21.17 0.64 9.3e-76 Anterior chamber depth; BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.19 -0.31 1.47e-15 Total body bone mineral density; BRCA cis rs7131987 0.903 rs1991114 chr12:29392082 G/T cg09582351 chr12:29534625 ERGIC2 -0.48 -11.65 -0.42 1.4e-28 QT interval; BRCA cis rs2742234 0.955 rs2503849 chr10:43672776 G/A cg02780029 chr10:43622663 RET -0.39 -9.59 -0.35 1.95e-20 Hirschsprung disease; BRCA cis rs9858542 0.953 rs11713474 chr3:49611457 A/G cg03060546 chr3:49711283 APEH -0.56 -11.48 -0.41 7.03e-28 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs5167 0.539 rs4803783 chr19:45470458 G/C cg09555818 chr19:45449301 APOC2 -0.35 -7.95 -0.3 8.52e-15 Blood protein levels; BRCA cis rs7666738 0.648 rs33988750 chr4:98985386 T/C cg17366294 chr4:99064904 C4orf37 0.49 8.34 0.31 4.67e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg23625390 chr15:77176239 SCAPER 0.41 10.13 0.37 1.82e-22 Blood metabolite levels; BRCA cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg06238570 chr21:40685208 BRWD1 -0.4 -8.18 -0.31 1.54e-15 Menarche (age at onset); BRCA trans rs4332037 0.624 rs58169303 chr7:1883274 T/C cg25206134 chr2:45395956 NA 0.53 8.93 0.33 4.46e-18 Bipolar disorder; BRCA cis rs600806 0.850 rs11102981 chr1:109967323 G/C cg20591472 chr1:110008990 SYPL2 0.33 8.31 0.31 5.69e-16 Intelligence (multi-trait analysis); BRCA cis rs9287719 1.000 rs9679122 chr2:10751710 T/C cg00105475 chr2:10696890 NA 0.44 10.21 0.37 9.35e-23 Prostate cancer; BRCA cis rs12142240 0.698 rs1135460 chr1:46815970 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs13046373 0.508 rs1911572 chr21:32031648 A/G cg16812893 chr21:31813075 KRTAP15-1 -0.37 -9.33 -0.35 1.71e-19 HDL cholesterol; BRCA cis rs12477438 0.520 rs720229 chr2:99704273 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.83 25.82 0.71 2.97e-101 Chronic sinus infection; BRCA cis rs2882667 0.964 rs12108892 chr5:138299630 G/A cg04439458 chr5:138467593 SIL1 -0.32 -8.77 -0.33 1.58e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg22920501 chr2:26401640 FAM59B 0.95 16.32 0.54 2.51e-50 Gut microbiome composition (summer); BRCA cis rs6930083 0.713 rs1321309 chr6:36638636 G/A cg08179530 chr6:36648295 CDKN1A -0.68 -16.36 -0.54 1.58e-50 Coronary artery disease; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs8044868 1.000 rs8052408 chr16:72158077 C/T cg16558253 chr16:72132732 DHX38 -0.37 -8.83 -0.33 9.94e-18 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs10927875 0.541 rs761759 chr1:16342350 A/T cg22431228 chr1:16359049 CLCNKA -0.43 -9.71 -0.36 6.72e-21 Dilated cardiomyopathy; BRCA cis rs4718428 0.960 rs6460317 chr7:66390255 A/G cg12165864 chr7:66369176 NA -0.34 -8.33 -0.31 4.86e-16 Corneal structure; BRCA cis rs10504229 0.679 rs7839948 chr8:58130607 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.745 rs10952801 chr7:148864757 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.14 0.34 8.49e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10782582 0.609 rs80059220 chr1:76279112 G/T cg03433033 chr1:76189801 ACADM -0.4 -8.14 -0.31 2.01e-15 Daytime sleep phenotypes; BRCA cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg10523679 chr1:76189770 ACADM 0.88 20.7 0.63 2.98e-73 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg26314531 chr2:26401878 FAM59B -0.79 -12.64 -0.45 7.76e-33 Gut microbiome composition (summer); BRCA cis rs2637266 0.935 rs1866890 chr10:78397073 C/T cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs7937682 0.881 rs4936678 chr11:111625085 C/T cg09085632 chr11:111637200 PPP2R1B 0.96 19.42 0.61 2.35e-66 Primary sclerosing cholangitis; BRCA cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.1 0.4 2.68e-26 Bipolar disorder; BRCA cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg17366294 chr4:99064904 C4orf37 -0.43 -9.65 -0.36 1.19e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.715 rs116787789 chr4:98718720 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.85e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7512552 0.839 rs1260367 chr1:150344514 C/T cg15654264 chr1:150340011 RPRD2 0.38 8.44 0.32 2.06e-16 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs2836950 0.565 rs2836926 chr21:40536790 G/A cg11890956 chr21:40555474 PSMG1 -0.6 -13.33 -0.47 6.34e-36 Menarche (age at onset); BRCA cis rs10504229 0.683 rs882429 chr8:58129292 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs3892630 0.878 rs2903759 chr19:33195947 A/G cg22980127 chr19:33182716 NUDT19 0.9 18.21 0.58 5.64e-60 Red blood cell traits; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg15112475 chr7:1198522 ZFAND2A -0.57 -14.17 -0.49 8.2e-40 Longevity;Endometriosis; BRCA cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg05340658 chr4:99064831 C4orf37 0.7 17.55 0.57 1.4e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6964587 0.967 rs58673519 chr7:91823887 T/G cg01689657 chr7:91764605 CYP51A1 0.25 8.84 0.33 9.31e-18 Breast cancer; BRCA cis rs17401966 0.537 rs3748575 chr1:10342352 C/T cg03954927 chr1:10346856 KIF1B 0.34 10.22 0.37 8.55e-23 Hepatocellular carcinoma; BRCA cis rs6964587 1.000 rs6961928 chr7:91669808 C/T cg17063962 chr7:91808500 NA 0.57 13.52 0.47 8.47e-37 Breast cancer; BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg08470875 chr2:26401718 FAM59B 0.74 10.26 0.38 5.59e-23 Gut microbiome composition (summer); BRCA cis rs6815814 0.950 rs5743571 chr4:38805489 C/T cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs2280018 0.963 rs11075255 chr16:15166232 A/G cg07549590 chr16:15018862 NA -0.36 -8.96 -0.33 3.63e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg15112475 chr7:1198522 ZFAND2A -0.39 -8.37 -0.31 3.69e-16 Longevity;Endometriosis; BRCA cis rs713587 0.563 rs11686663 chr2:25107759 C/T cg01884057 chr2:25150051 NA 0.29 7.86 0.3 1.67e-14 Body mass index in non-asthmatics; BRCA cis rs9647379 0.935 rs17460016 chr3:171774601 G/C cg16233210 chr3:171778391 FNDC3B 0.41 8.78 0.33 1.52e-17 Heart rate; BRCA trans rs615632 0.570 rs17734541 chr8:9708433 A/G cg15556689 chr8:8085844 FLJ10661 0.33 8.44 0.32 2.14e-16 Neuroticism; BRCA cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg18230493 chr5:56204884 C5orf35 0.88 16.87 0.56 4.31e-53 Initial pursuit acceleration; BRCA cis rs2066819 1.000 rs79101914 chr12:56729739 A/G cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg06494592 chr3:125709126 NA -0.51 -7.9 -0.3 1.18e-14 Blood pressure (smoking interaction); BRCA cis rs6901250 0.819 rs9374623 chr6:117127312 C/A cg12892004 chr6:117198278 RFX6 0.49 11.44 0.41 1.03e-27 C-reactive protein levels; BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg22920501 chr2:26401640 FAM59B -0.63 -11.21 -0.41 9.73e-27 Gut microbiome composition (summer); BRCA cis rs735860 0.763 rs6458912 chr6:53147965 G/A cg10236188 chr6:53219634 NA -0.39 -8.27 -0.31 8.02e-16 Glaucoma; BRCA cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg24977027 chr2:88469347 THNSL2 0.57 9.58 0.35 2.04e-20 Plasma clusterin levels; BRCA cis rs13102973 0.931 rs12643821 chr4:135859614 A/G cg14419869 chr4:135874104 NA -0.59 -12.96 -0.46 2.78e-34 Subjective well-being; BRCA cis rs780094 0.544 rs2303370 chr2:27651375 C/T cg22903471 chr2:27725779 GCKR -0.35 -8.57 -0.32 7.99e-17 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs2836974 0.932 rs8128734 chr21:40569511 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.39 0.61 3.4e-66 Cognitive function; BRCA cis rs858239 0.541 rs4624924 chr7:23168843 A/C cg23682824 chr7:23144976 KLHL7 0.41 10.97 0.4 9.04e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs427394 0.664 rs274696 chr5:6732213 A/C cg10857441 chr5:6722123 POLS -0.32 -10.9 -0.4 1.66e-25 Menopause (age at onset); BRCA cis rs826838 0.678 rs11182781 chr12:38610178 C/T cg26384229 chr12:38710491 ALG10B 0.78 18.25 0.59 3.33e-60 Heart rate; BRCA cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg04944784 chr2:26401820 FAM59B -0.48 -8.46 -0.32 1.76e-16 Gut microbiome composition (summer); BRCA cis rs11997175 0.766 rs60855034 chr8:33684732 G/A ch.8.33884649F chr8:33765107 NA 0.35 8.09 0.3 2.94e-15 Body mass index; BRCA cis rs72781680 0.851 rs12612830 chr2:24134599 C/T cg08917208 chr2:24149416 ATAD2B 0.94 14.03 0.49 3.44e-39 Lymphocyte counts; BRCA trans rs7819412 0.522 rs10088853 chr8:10987967 G/A cg15556689 chr8:8085844 FLJ10661 -0.35 -8.65 -0.32 4.21e-17 Triglycerides; BRCA cis rs10504229 0.683 rs67035623 chr8:58139963 G/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs765787 0.556 rs12915965 chr15:45512647 T/C cg24006582 chr15:45444508 DUOX1 0.56 11.23 0.41 8.18e-27 Uric acid levels; BRCA cis rs1843834 0.505 rs3820763 chr2:225347270 A/G cg22455342 chr2:225449267 CUL3 -0.66 -17.26 -0.56 4.58e-55 IgE levels in asthmatics (D.p. specific); BRCA cis rs9486719 1.000 rs11153018 chr6:96956137 G/A cg06623918 chr6:96969491 KIAA0776 -0.73 -13.08 -0.46 8.41e-35 Migraine;Coronary artery disease; BRCA trans rs208520 0.661 rs1100950 chr6:66827285 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.65 -0.63 5.57e-73 Exhaled nitric oxide output; BRCA cis rs887829 0.694 rs869283 chr2:234626287 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.37 -9.17 -0.34 6.59e-19 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs705471 0.762 rs7919625 chr10:3669970 A/G cg14308648 chr10:3568949 NA 0.39 10.08 0.37 2.78e-22 Capecitabine sensitivity; BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg14004847 chr7:1930337 MAD1L1 -0.43 -8.16 -0.31 1.75e-15 Bipolar disorder and schizophrenia; BRCA cis rs7613875 0.578 rs2624822 chr3:50107219 T/C cg14019146 chr3:50243930 SLC38A3 0.36 8.96 0.33 3.53e-18 Body mass index; BRCA cis rs1904096 0.506 rs4693378 chr4:95168552 A/T cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.2 -0.37 9.63e-23 Type 2 diabetes; BRCA trans rs35110281 0.693 rs11089093 chr21:45121161 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.97 0.33 3.17e-18 Mean corpuscular volume; BRCA cis rs4718428 0.705 rs4717328 chr7:66352665 T/C cg12165864 chr7:66369176 NA -0.46 -10.34 -0.38 2.74e-23 Corneal structure; BRCA cis rs2228479 0.717 rs11649210 chr16:89807233 C/G cg00800038 chr16:89945340 TCF25 -0.55 -8.22 -0.31 1.15e-15 Skin colour saturation; BRCA cis rs929596 0.639 rs7571915 chr2:234586574 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.38 -9.47 -0.35 5.23e-20 Total bilirubin levels in HIV-1 infection; BRCA cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.59 -11.87 -0.42 1.6800000000000001e-29 Tonsillectomy; BRCA cis rs4074536 0.574 rs10754351 chr1:116292355 G/A cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 4.94e-17 QRS duration; BRCA cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg02574844 chr11:5959923 NA -0.38 -8.33 -0.31 4.91e-16 DNA methylation (variation); BRCA cis rs13191362 1.000 rs35383933 chr6:163002869 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.3 0.44 2.45e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 9.31 0.35 1.97e-19 Cognitive function; BRCA cis rs9649213 0.593 rs12704982 chr7:97926053 C/T cg21770322 chr7:97807741 LMTK2 0.42 11.28 0.41 4.79e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.898 rs72788214 chr2:24087621 A/C cg20701182 chr2:24300061 SF3B14 0.58 9.0 0.34 2.55e-18 Lymphocyte counts; BRCA cis rs4975709 0.610 rs4975706 chr5:1860365 G/T cg01283332 chr5:1856932 NA -0.36 -8.87 -0.33 7.31e-18 Cardiovascular disease risk factors; BRCA cis rs10751667 0.666 rs4074235 chr11:977511 C/G cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs897984 0.520 rs4889534 chr16:30865440 T/C cg02466173 chr16:30829666 NA 0.46 9.23 0.34 4.05e-19 Dementia with Lewy bodies; BRCA cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg17892150 chr10:133769511 PPP2R2D -0.72 -15.28 -0.52 3.72e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs8177253 0.763 rs8177224 chr3:133474003 C/G cg11941060 chr3:133502564 NA 0.38 8.64 0.32 4.44e-17 Iron status biomarkers; BRCA cis rs8072100 0.807 rs2175290 chr17:45479917 C/A cg08085267 chr17:45401833 C17orf57 -0.68 -15.24 -0.52 5.78e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs826838 0.510 rs17523988 chr12:39222785 A/C cg26384229 chr12:38710491 ALG10B 0.67 14.37 0.49 9.24e-41 Heart rate; BRCA cis rs4988958 0.548 rs6543127 chr2:103028301 A/C cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.63e-16 Asthma (childhood onset); BRCA cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.660 rs7520497 chr1:46824919 C/A cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA cis rs7737355 0.947 rs31583 chr5:130992432 T/C cg06307176 chr5:131281290 NA 0.53 10.39 0.38 1.87e-23 Life satisfaction; BRCA cis rs9309711 0.666 rs11127429 chr2:3485224 T/G cg15506890 chr2:3487001 NA -0.59 -13.33 -0.47 5.98e-36 Neurofibrillary tangles; BRCA cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg08069147 chr6:88032118 GJB7;C6orf162 0.56 11.87 0.42 1.74e-29 Monocyte percentage of white cells; BRCA cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs870825 0.860 rs72703526 chr4:185605676 A/T cg04058563 chr4:185651563 MLF1IP 0.67 11.59 0.42 2.49e-28 Blood protein levels; BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg13732083 chr21:47605072 C21orf56 0.38 8.14 0.31 2.01e-15 Testicular germ cell tumor; BRCA trans rs7613875 0.521 rs4688754 chr3:50074641 G/T cg21659725 chr3:3221576 CRBN -0.33 -7.93 -0.3 9.93e-15 Body mass index; BRCA cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg04450456 chr4:17643702 FAM184B 0.36 10.65 0.39 1.71e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg24612305 chr17:17875800 TOM1L2;LRRC48 0.4 10.29 0.38 4.58e-23 Total body bone mineral density; BRCA cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg07930192 chr7:1003750 NA 0.44 9.94 0.37 9.66e-22 Longevity;Endometriosis; BRCA cis rs9649213 0.593 rs6967457 chr7:97912221 T/G cg24562669 chr7:97807699 LMTK2 0.46 12.4 0.44 8.74e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs11774697 chr8:58133119 G/A cg20607798 chr8:58055168 NA 0.56 8.74 0.33 2.1e-17 Developmental language disorder (linguistic errors); BRCA cis rs877282 0.838 rs34778553 chr10:796865 T/C cg17470449 chr10:769945 NA 0.51 8.76 0.33 1.76e-17 Uric acid levels; BRCA cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg03433033 chr1:76189801 ACADM -0.76 -17.09 -0.56 3.47e-54 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.6 -11.57 -0.42 3.02e-28 Gut microbiome composition (summer); BRCA cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg15691649 chr6:25882328 NA -0.56 -10.46 -0.38 9.7e-24 Urate levels; BRCA cis rs765787 0.505 rs4439707 chr15:45524216 G/A cg25801113 chr15:45476975 SHF -0.33 -8.05 -0.3 3.99e-15 Uric acid levels; BRCA cis rs698833 0.518 rs2033951 chr2:44556298 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.0 0.34 2.5e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2882667 0.628 rs10076629 chr5:138255961 G/C cg04439458 chr5:138467593 SIL1 -0.35 -8.54 -0.32 9.46e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs56104184 0.775 rs55981795 chr19:49401952 A/C cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs1580019 0.885 rs4460270 chr7:32496450 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.57 0.32 7.83e-17 Cognitive ability; BRCA cis rs9942416 0.660 rs2047059 chr5:75008193 T/C cg19683494 chr5:74908142 NA 0.43 8.37 0.31 3.6e-16 Age-related disease endophenotypes; BRCA trans rs11098499 0.866 rs13125526 chr4:120288019 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs7131987 0.650 rs7957339 chr12:29456495 T/C cg09582351 chr12:29534625 ERGIC2 -0.43 -9.93 -0.37 1.07e-21 QT interval; BRCA cis rs4819052 0.724 rs1304487 chr21:46657283 C/G cg11663144 chr21:46675770 NA 0.55 12.98 0.46 2.4e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7590720 1.000 rs6755934 chr2:216907198 C/A cg12620499 chr2:216877984 MREG 0.78 21.41 0.65 4.36e-77 Alcohol dependence; BRCA cis rs4803468 0.967 rs3213860 chr19:41920211 T/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.39 -0.68 7.13e-88 Height; BRCA cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg18876405 chr7:65276391 NA 0.55 13.15 0.46 3.95e-35 Aortic root size; BRCA cis rs10771431 0.810 rs10771418 chr12:9358995 A/G cg00504896 chr12:9437009 LOC642846 -0.37 -7.96 -0.3 7.96e-15 Breast size; BRCA cis rs9811920 0.809 rs793437 chr3:99559854 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.53 -12.6 -0.45 1.1e-32 Axial length; BRCA trans rs6582630 0.537 rs3942440 chr12:38459672 A/G cg06521331 chr12:34319734 NA -0.47 -8.62 -0.32 5.41e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7264396 0.790 rs6058294 chr20:34259396 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -16.25 -0.54 5.74e-50 Total cholesterol levels; BRCA cis rs11229555 1.000 rs11229545 chr11:58386650 A/G cg15696309 chr11:58395628 NA -0.53 -11.58 -0.42 2.85e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs875971 0.862 rs7782704 chr7:65805366 G/A cg18876405 chr7:65276391 NA -0.51 -11.59 -0.42 2.49e-28 Aortic root size; BRCA trans rs10506458 0.915 rs17687426 chr12:63397900 G/C cg22491629 chr6:157744540 C6orf35 -0.67 -12.37 -0.44 1.15e-31 Hemostatic factors and hematological phenotypes; BRCA cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg12373951 chr3:133503437 NA -0.5 -11.57 -0.42 3.09e-28 Iron status biomarkers; BRCA trans rs4596713 0.507 rs2309424 chr9:71806370 A/G cg16512924 chr15:28394682 HERC2 0.44 10.41 0.38 1.49e-23 Headache; BRCA cis rs12497850 1.000 rs10865952 chr3:48744484 A/G cg07636037 chr3:49044803 WDR6 0.88 23.95 0.69 5.82e-91 Parkinson's disease; BRCA trans rs3857536 0.740 rs6455080 chr6:66887413 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.49 -9.77 -0.36 4.07e-21 Blood trace element (Cu levels); BRCA cis rs2842992 0.915 rs1322427 chr6:160075454 C/A cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.1 0.4 2.68e-26 Age-related macular degeneration (geographic atrophy); BRCA cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.49e-34 Alzheimer's disease (late onset); BRCA cis rs12579753 0.917 rs6539580 chr12:82184765 T/C cg07988820 chr12:82153109 PPFIA2 -0.48 -8.37 -0.31 3.52e-16 Resting heart rate; BRCA cis rs6088590 1.000 rs910870 chr20:33292893 T/C cg24642439 chr20:33292090 TP53INP2 0.61 13.3 0.47 8.37e-36 Coronary artery disease; BRCA trans rs61931739 0.517 rs11513519 chr12:34075077 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.05 0.49 2.73e-39 Morning vs. evening chronotype; BRCA cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg15556689 chr8:8085844 FLJ10661 0.47 13.08 0.46 8.11e-35 Mood instability; BRCA cis rs5753037 0.543 rs140126 chr22:30147038 A/G cg01021169 chr22:30184971 ASCC2 -0.4 -9.6 -0.35 1.84e-20 Type 1 diabetes; BRCA cis rs868036 1.000 rs4776377 chr15:68103387 T/C cg08079166 chr15:68083412 MAP2K5 0.35 9.46 0.35 5.8e-20 Restless legs syndrome; BRCA trans rs2797160 0.967 rs1739355 chr6:126018114 A/G cg05039488 chr6:79577232 IRAK1BP1 0.36 7.95 0.3 8.19e-15 Endometrial cancer; BRCA cis rs13095912 0.638 rs6791369 chr3:185289989 C/A cg11274856 chr3:185301563 NA 0.54 12.83 0.45 1.1e-33 Systolic blood pressure; BRCA cis rs2153535 0.580 rs9406174 chr6:8516764 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.83e-24 Motion sickness; BRCA cis rs4727027 0.901 rs4727018 chr7:148822247 G/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 9.02 0.34 2.13e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs36051895 0.659 rs62541538 chr9:5038164 G/A cg02405213 chr9:5042618 JAK2 -0.51 -9.17 -0.34 6.66e-19 Pediatric autoimmune diseases; BRCA cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg04455712 chr21:45112962 RRP1B -0.37 -9.87 -0.36 1.76e-21 Mean corpuscular volume; BRCA cis rs11190604 1.000 rs2003284 chr10:102202338 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.32 0.41 3.25e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs11098499 1.000 rs1011054 chr4:120202387 A/G cg09307838 chr4:120376055 NA -0.61 -11.68 -0.42 1.02e-28 Corneal astigmatism; BRCA cis rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05901451 chr6:126070800 HEY2 0.45 11.14 0.4 1.79e-26 Endometrial cancer; BRCA cis rs2652834 0.821 rs7174174 chr15:63372327 A/G cg05507819 chr15:63340323 TPM1 -0.43 -8.62 -0.32 5.4e-17 HDL cholesterol; BRCA cis rs1707322 1.000 rs4539075 chr1:46358010 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.76 0.39 6.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs72781680 0.898 rs72796166 chr2:23939311 G/C cg20701182 chr2:24300061 SF3B14 0.62 8.86 0.33 8.1e-18 Lymphocyte counts; BRCA cis rs11083475 0.557 rs2368519 chr19:39259241 C/T cg07403899 chr19:39283540 NA -0.32 -11.01 -0.4 6.1e-26 Heart rate; BRCA cis rs6546550 0.867 rs7592647 chr2:70139134 C/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.46 -0.41 8.89e-28 Prevalent atrial fibrillation; BRCA cis rs11229555 0.574 rs12272096 chr11:58186118 A/G cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9649213 0.593 rs6465678 chr7:98004057 T/C cg21770322 chr7:97807741 LMTK2 0.41 10.69 0.39 1.16e-24 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.7 -0.36 7.54e-21 Developmental language disorder (linguistic errors); BRCA cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.29 0.49 2.24e-40 Colorectal cancer; BRCA cis rs861020 0.677 rs12723578 chr1:210032392 G/A cg09163369 chr1:210001066 C1orf107 -0.58 -10.18 -0.37 1.19e-22 Orofacial clefts; BRCA cis rs7666738 0.830 rs10005120 chr4:99038200 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.62 0.39 2.18e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs34313689 chr4:99013689 T/C cg05340658 chr4:99064831 C4orf37 0.68 17.25 0.56 4.98e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9463078 0.547 rs4711798 chr6:44750777 A/G cg25276700 chr6:44698697 NA -0.35 -7.85 -0.3 1.73e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg01262667 chr19:19385393 TM6SF2 -0.41 -10.7 -0.39 1.12e-24 Tonsillectomy; BRCA cis rs7267979 1.000 rs1046073 chr20:25281333 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.1e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11098499 0.580 rs12509234 chr4:120319434 T/C cg09307838 chr4:120376055 NA 0.73 15.87 0.53 4.5e-48 Corneal astigmatism; BRCA cis rs13046373 0.535 rs13051529 chr21:32029743 G/C cg16431978 chr21:31797932 KRTAP13-3 0.35 8.59 0.32 6.47e-17 HDL cholesterol; BRCA cis rs1113500 0.836 rs1618973 chr1:108586767 T/C cg06207961 chr1:108661230 NA -0.41 -9.78 -0.36 3.87e-21 Growth-regulated protein alpha levels; BRCA cis rs6570726 0.935 rs368848 chr6:145855281 A/T cg23711669 chr6:146136114 FBXO30 0.64 14.92 0.51 2e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg21747090 chr2:27597821 SNX17 -0.43 -9.22 -0.34 4.27e-19 Total body bone mineral density; BRCA trans rs3942852 0.806 rs1875696 chr11:48133526 G/A cg03929089 chr4:120376271 NA -0.42 -7.85 -0.3 1.74e-14 Acute lymphoblastic leukemia (childhood); BRCA trans rs7824557 0.767 rs10104728 chr8:11171300 A/G cg15556689 chr8:8085844 FLJ10661 0.37 8.52 0.32 1.13e-16 Retinal vascular caliber; BRCA cis rs2153535 0.580 rs1414350 chr6:8472331 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2836974 0.965 rs2836967 chr21:40639102 T/G cg17971929 chr21:40555470 PSMG1 0.78 18.36 0.59 8.61e-61 Cognitive function; BRCA cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg11663144 chr21:46675770 NA -0.57 -13.57 -0.47 5e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs10411161 0.702 rs7250138 chr19:52385232 G/C cg22319618 chr22:45562946 NUP50 -0.41 -7.86 -0.3 1.62e-14 Breast cancer; BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.52 8.37 0.31 3.53e-16 Renal function-related traits (BUN); BRCA trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg17788362 chr6:86352627 SYNCRIP 0.44 8.6 0.32 6.08e-17 Smooth-surface caries; BRCA cis rs10754283 0.934 rs6661282 chr1:90119992 C/T cg21401794 chr1:90099060 LRRC8C 0.49 11.67 0.42 1.15e-28 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs11098499 0.954 rs6834796 chr4:120414693 A/C cg09307838 chr4:120376055 NA 0.72 15.24 0.52 5.6e-45 Corneal astigmatism; BRCA cis rs2991971 1.000 rs2991972 chr1:46013208 C/T cg24296786 chr1:45957014 TESK2 0.62 15.39 0.52 1.12e-45 High light scatter reticulocyte count; BRCA cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg17971929 chr21:40555470 PSMG1 -0.49 -10.98 -0.4 8.4e-26 Menarche (age at onset); BRCA cis rs6860806 0.661 rs6871350 chr5:131580220 A/G cg09877947 chr5:131593287 PDLIM4 0.39 10.05 0.37 3.72e-22 Breast cancer; BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -8.65 -0.32 4.06e-17 Bipolar disorder and schizophrenia; BRCA cis rs1018836 0.739 rs4734247 chr8:91569144 A/G cg16814680 chr8:91681699 NA -0.57 -12.34 -0.44 1.54e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9400271 0.527 rs11759269 chr6:109640488 C/T cg01475377 chr6:109611718 NA -0.36 -8.15 -0.31 1.91e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA trans rs7980799 0.682 rs1601005 chr12:33634658 A/G cg26384229 chr12:38710491 ALG10B -0.48 -10.46 -0.38 9.36e-24 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6461049 0.608 rs3800923 chr7:2184673 A/G cg00106254 chr7:1943704 MAD1L1 -0.31 -8.21 -0.31 1.19e-15 Schizophrenia; BRCA cis rs7512552 0.839 rs834229 chr1:150384665 G/C cg15654264 chr1:150340011 RPRD2 0.43 9.21 0.34 4.75e-19 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs7647973 1.000 rs13088309 chr3:49368317 A/G cg07636037 chr3:49044803 WDR6 0.7 14.87 0.51 3.64e-43 Menarche (age at onset); BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 14.09 0.49 1.82e-39 Alzheimer's disease; BRCA cis rs12545109 0.800 rs2576592 chr8:57419357 A/C cg09654669 chr8:57350985 NA -0.39 -8.59 -0.32 6.42e-17 Obesity-related traits; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg27588902 chr6:42928151 GNMT -0.31 -10.37 -0.38 2.22e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg00814883 chr7:100076585 TSC22D4 -0.47 -10.57 -0.39 3.41e-24 Platelet count; BRCA cis rs2204008 0.658 rs12371956 chr12:38298010 A/T cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Bladder cancer; BRCA cis rs2280018 0.963 rs4985147 chr16:15168760 T/C cg07549590 chr16:15018862 NA -0.36 -8.93 -0.33 4.4e-18 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12048904 0.619 rs10875347 chr1:101333737 T/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.52 11.59 0.42 2.52e-28 Multiple sclerosis; BRCA cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.28 0.31 7.05e-16 Aortic root size; BRCA cis rs7178424 1.000 rs12594658 chr15:62305090 A/G cg00456672 chr15:62358751 C2CD4A -0.39 -8.79 -0.33 1.41e-17 Height; BRCA cis rs589448 0.967 rs634512 chr12:69754012 C/T cg14784868 chr12:69753453 YEATS4 0.79 25.23 0.71 5.18e-98 Cerebrospinal fluid biomarker levels; BRCA cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg15556689 chr8:8085844 FLJ10661 0.52 15.7 0.53 3.05e-47 Mood instability; BRCA cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg11742103 chr11:62369870 EML3;MTA2 0.52 10.96 0.4 1.02e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs3806843 1.000 rs6870764 chr5:140171790 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.8 -0.36 3.32e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs55986470 0.670 rs56313033 chr2:239346202 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 9.84 0.36 2.29e-21 Chronotype; BRCA cis rs2576037 0.583 rs11660085 chr18:44529603 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -14.79 -0.51 8.48e-43 Personality dimensions; BRCA cis rs7647973 0.626 rs62260720 chr3:49853796 T/A cg03060546 chr3:49711283 APEH -0.6 -10.41 -0.38 1.47e-23 Menarche (age at onset); BRCA cis rs62103177 0.525 rs4799117 chr18:77756604 G/A cg02751453 chr18:77725136 HSBP1L1 0.38 9.2 0.34 4.99e-19 Opioid sensitivity; BRCA cis rs12986413 0.967 rs2108524 chr19:2170764 A/G cg09261902 chr19:2140048 AP3D1 0.37 9.76 0.36 4.41e-21 Height; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg24642844 chr7:1081250 C7orf50 -0.69 -13.09 -0.46 7.38e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs312273 0.582 rs312268 chr12:41250534 C/A cg17827154 chr12:41323612 CNTN1 -0.34 -7.89 -0.3 1.34e-14 Bipolar disorder; BRCA trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg15704280 chr7:45808275 SEPT13 -0.54 -10.77 -0.39 5.61e-25 HDL cholesterol; BRCA cis rs9341808 0.690 rs2322634 chr6:80874014 A/C cg08355045 chr6:80787529 NA 0.37 9.25 0.34 3.25e-19 Sitting height ratio; BRCA cis rs870825 0.616 rs7681824 chr4:185617525 A/G cg04058563 chr4:185651563 MLF1IP 0.77 16.71 0.55 2.8e-52 Blood protein levels; BRCA trans rs7395662 0.591 rs7483212 chr11:48607182 T/A cg15704280 chr7:45808275 SEPT13 -0.49 -9.64 -0.36 1.29e-20 HDL cholesterol; BRCA cis rs1707322 0.929 rs785500 chr1:46593044 C/T cg03146154 chr1:46216737 IPP -0.43 -9.13 -0.34 8.71e-19 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg16586182 chr3:47516702 SCAP -0.64 -15.01 -0.51 7.9e-44 Colorectal cancer; BRCA cis rs10751667 0.666 rs4074231 chr11:978219 G/C cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 -1.08 -21.82 -0.65 2.51e-79 Platelet count; BRCA cis rs56399783 0.901 rs56356906 chr7:2774383 G/A cg23627948 chr7:2760692 NA 0.51 8.23 0.31 1.03e-15 Childhood ear infection; BRCA trans rs11098499 0.754 rs12510269 chr4:120241646 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.32 0.38 3.46e-23 Corneal astigmatism; BRCA cis rs2836633 0.929 rs11702165 chr21:40035313 C/T cg05519781 chr21:40033154 ERG 0.45 9.59 0.35 1.8899999999999998e-20 Coronary artery disease; BRCA cis rs7520050 0.898 rs4660885 chr1:46243756 C/T cg03146154 chr1:46216737 IPP -0.34 -8.01 -0.3 5.34e-15 Red blood cell count;Reticulocyte count; BRCA cis rs4253772 0.744 rs9627278 chr22:46643432 C/G cg24881330 chr22:46731750 TRMU 0.42 7.87 0.3 1.51e-14 LDL cholesterol;Cholesterol, total; BRCA cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1348850 0.872 rs13004955 chr2:178398923 A/T cg02961200 chr2:178257176 LOC100130691;AGPS -0.45 -9.08 -0.34 1.35e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg24642439 chr20:33292090 TP53INP2 0.54 11.77 0.42 4.61e-29 Glomerular filtration rate (creatinine); BRCA cis rs8114671 0.562 rs6087641 chr20:33467717 T/C cg24642439 chr20:33292090 TP53INP2 0.43 9.35 0.35 1.45e-19 Height; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg08805041 chr16:621841 PIGQ -0.31 -8.32 -0.31 5.26e-16 Height; BRCA cis rs1506636 1.000 rs2215554 chr7:123347063 A/C cg03229431 chr7:123269106 ASB15 -0.59 -13.13 -0.46 4.7e-35 Plateletcrit;Platelet count; BRCA cis rs60871478 0.636 rs73045423 chr7:893952 G/A cg22972055 chr7:872293 UNC84A 0.39 8.68 0.32 3.38e-17 Cerebrospinal P-tau181p levels; BRCA cis rs853679 0.517 rs9368552 chr6:28068426 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.12 -0.31 2.49e-15 Depression; BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.13 0.6 8.2e-65 Platelet count; BRCA cis rs2836633 0.929 rs62217519 chr21:40034390 G/A cg05519781 chr21:40033154 ERG 0.45 9.57 0.35 2.34e-20 Coronary artery disease; BRCA cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg20946044 chr11:1010712 AP2A2 -0.37 -7.87 -0.3 1.58e-14 Alzheimer's disease (late onset); BRCA cis rs11123610 0.520 rs60644898 chr2:3718646 G/A cg19052272 chr2:3704530 ALLC -0.45 -10.09 -0.37 2.64e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs4862750 0.914 rs1863405 chr4:187874528 G/T cg03452623 chr4:187889614 NA 0.35 11.6 0.42 2.21e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs4074536 0.574 rs7518735 chr1:116287982 G/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.67 -0.32 3.44e-17 QRS duration; BRCA cis rs12142240 0.698 rs17361833 chr1:46828700 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.4 -0.35 9.47e-20 Menopause (age at onset); BRCA trans rs7647973 0.710 rs6797299 chr3:49609794 G/T cg21659725 chr3:3221576 CRBN -0.49 -8.5 -0.32 1.31e-16 Menarche (age at onset); BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg26314531 chr2:26401878 FAM59B 0.88 15.31 0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs243505 1.000 rs243507 chr7:148434600 G/A cg09806900 chr7:148480153 CUL1 -0.44 -8.87 -0.33 7.47e-18 Inflammatory bowel disease;Crohn's disease; BRCA trans rs6582630 0.502 rs10880388 chr12:38401341 A/T cg06521331 chr12:34319734 NA -0.46 -8.48 -0.32 1.58e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs11249608 0.548 rs6875473 chr5:178451387 C/A cg21905437 chr5:178450457 ZNF879 0.54 11.31 0.41 3.58e-27 Pubertal anthropometrics; BRCA cis rs6723226 0.803 rs176415 chr2:32649778 G/A cg02381751 chr2:32503542 YIPF4 -0.72 -16.01 -0.53 9.72e-49 Intelligence (multi-trait analysis); BRCA trans rs2797160 1.000 rs77678056 chr6:126019738 A/G cg05039488 chr6:79577232 IRAK1BP1 0.35 7.85 0.3 1.75e-14 Endometrial cancer; BRCA trans rs9325144 0.555 rs10748433 chr12:38696352 C/G cg23762105 chr12:34175262 ALG10 -0.39 -9.6 -0.36 1.75e-20 Morning vs. evening chronotype; BRCA cis rs2204008 0.837 rs7308714 chr12:38274307 T/C cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.88e-18 Bladder cancer; BRCA cis rs10504229 1.000 rs59071610 chr8:58186301 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.49 -0.44 3.43e-32 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.541 rs3755041 chr2:219442499 A/T cg10223061 chr2:219282414 VIL1 0.3 8.79 0.33 1.37e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs12541635 0.677 rs2029879 chr8:107024695 T/A cg10147462 chr8:107024639 NA 0.4 10.98 0.4 7.87e-26 Age of smoking initiation; BRCA cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.5 11.37 0.41 2.09e-27 Personality dimensions; BRCA cis rs7945705 0.747 rs2653605 chr11:8993309 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.58 -13.66 -0.48 1.81e-37 Hemoglobin concentration; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg15112475 chr7:1198522 ZFAND2A -0.52 -11.86 -0.42 1.81e-29 Longevity;Endometriosis; BRCA cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.25 -0.41 6.69e-27 Schizophrenia; BRCA cis rs7524258 0.903 rs763197 chr1:7289959 A/G cg07173049 chr1:7289937 CAMTA1 0.55 13.42 0.47 2.47e-36 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs9469578 0.901 rs16869459 chr6:33714908 G/A cg18708504 chr6:33715942 IP6K3 0.7 10.2 0.37 9.54e-23 Phosphorus levels; BRCA cis rs6430585 0.697 rs1050115 chr2:136511817 A/G cg07169764 chr2:136633963 MCM6 1.22 25.69 0.71 1.7e-100 Corneal structure; BRCA cis rs9467711 0.591 rs35249036 chr6:26026163 C/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.22 0.34 4.11e-19 Autism spectrum disorder or schizophrenia; BRCA trans rs2204008 0.747 rs11514040 chr12:38201040 G/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs514406 0.792 rs481440 chr1:53344976 C/T cg27535305 chr1:53392650 SCP2 -0.49 -12.3 -0.44 2.25e-31 Monocyte count; BRCA cis rs40363 0.951 rs250632 chr16:3523047 C/T cg22508957 chr16:3507546 NAT15 0.66 11.45 0.41 9.26e-28 Tuberculosis; BRCA cis rs7072216 0.763 rs12259939 chr10:100169021 T/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.61 -0.36 1.62e-20 Metabolite levels; BRCA cis rs35110281 0.807 rs4818850 chr21:45028071 T/G cg04455712 chr21:45112962 RRP1B 0.4 10.7 0.39 1.1e-24 Mean corpuscular volume; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg21747090 chr2:27597821 SNX17 -0.41 -8.98 -0.33 3.08e-18 Total body bone mineral density; BRCA cis rs2836950 0.501 rs35994303 chr21:40686020 C/T cg06238570 chr21:40685208 BRWD1 -0.4 -8.03 -0.3 4.86e-15 Menarche (age at onset); BRCA cis rs921968 0.541 rs2710246 chr2:219533894 C/T cg02176678 chr2:219576539 TTLL4 0.41 10.82 0.39 3.46e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA cis rs933688 1.000 rs6866191 chr5:90746852 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 19.97 0.62 2.72e-69 Smoking behavior; BRCA trans rs9291683 0.588 rs4280729 chr4:10013861 C/T cg26043149 chr18:55253948 FECH 0.4 8.64 0.32 4.54e-17 Bone mineral density; BRCA cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg03146154 chr1:46216737 IPP 0.46 10.24 0.38 7.01e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6964587 0.934 rs6973792 chr7:91749798 C/A cg01689657 chr7:91764605 CYP51A1 0.24 8.71 0.33 2.53e-17 Breast cancer; BRCA cis rs11734570 0.581 rs73811715 chr4:38590569 A/C cg18361445 chr4:38666374 KLF3;FLJ13197 0.52 9.7 0.36 7.44e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17376456 0.877 rs10073039 chr5:93467709 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.84 0.33 9.32e-18 Diabetic retinopathy; BRCA cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg11890956 chr21:40555474 PSMG1 -0.82 -19.2 -0.6 3.23e-65 Cognitive function; BRCA cis rs929596 0.556 rs35984508 chr2:234587852 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.35 -8.94 -0.33 4.02e-18 Total bilirubin levels in HIV-1 infection; BRCA cis rs7523273 0.526 rs2745980 chr1:208018367 A/C cg22525895 chr1:207977042 MIR29B2 0.47 12.15 0.43 1.1e-30 Schizophrenia; BRCA cis rs736408 0.562 rs12497998 chr3:52793602 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.3 0.44 2.26e-31 Bipolar disorder; BRCA cis rs9473147 0.543 rs4715025 chr6:47483653 C/G cg12968598 chr6:47444699 CD2AP 0.46 9.86 0.36 1.85e-21 Platelet distribution width;Mean platelet volume; BRCA trans rs3857536 0.776 rs7765531 chr6:66932886 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.11 -0.31 2.53e-15 Blood trace element (Cu levels); BRCA cis rs8103278 0.507 rs2041975 chr19:46238555 T/C cg14061069 chr19:46274453 DMPK 0.66 18.72 0.6 1.09e-62 Coronary artery disease; BRCA cis rs9473147 0.516 rs4715018 chr6:47441871 T/C cg12968598 chr6:47444699 CD2AP 0.45 9.37 0.35 1.24e-19 Platelet distribution width;Mean platelet volume; BRCA cis rs6120849 0.707 rs6120799 chr20:33614955 T/C cg24642439 chr20:33292090 TP53INP2 0.6 10.29 0.38 4.57e-23 Protein C levels; BRCA cis rs12142240 0.698 rs28578741 chr1:46825176 T/C cg14993813 chr1:46806288 NSUN4 -0.5 -9.47 -0.35 5.29e-20 Menopause (age at onset); BRCA trans rs1945213 0.694 rs7129022 chr11:55876132 A/G cg15704280 chr7:45808275 SEPT13 0.65 11.36 0.41 2.3e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg24829409 chr8:58192753 C8orf71 -0.49 -7.96 -0.3 7.93e-15 Developmental language disorder (linguistic errors); BRCA cis rs11605275 0.892 rs16937352 chr11:20032010 G/C cg14835545 chr11:20032148 NAV2 -0.59 -9.36 -0.35 1.28e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6484504 0.600 rs972714 chr11:31358875 T/G cg06552810 chr11:31128660 NA 0.39 8.58 0.32 7.02e-17 Red blood cell count; BRCA cis rs2549003 1.000 rs13170412 chr5:131823519 A/G cg21138405 chr5:131827807 IRF1 0.39 11.87 0.43 1.66e-29 Asthma (sex interaction); BRCA cis rs896854 0.596 rs7823059 chr8:95974961 T/C cg16049864 chr8:95962084 TP53INP1 -0.44 -10.77 -0.39 5.57e-25 Type 2 diabetes; BRCA cis rs10037055 1.000 rs10037055 chr5:176691279 G/T cg06733329 chr5:176740039 MXD3 0.42 9.84 0.36 2.33e-21 Migraine without aura; BRCA cis rs796364 0.616 rs1523818 chr2:200684704 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.34 0.31 4.51e-16 Schizophrenia; BRCA cis rs4891159 0.790 rs4891018 chr18:74127082 A/T cg24786174 chr18:74118243 ZNF516 -0.75 -18.95 -0.6 6.95e-64 Longevity; BRCA trans rs877282 0.945 rs11253398 chr10:790012 T/C cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs8072100 1.000 rs3809868 chr17:45750596 G/A cg25173405 chr17:45401733 C17orf57 0.51 10.65 0.39 1.66e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs35110281 0.501 rs162378 chr21:44925905 A/G cg01579765 chr21:45077557 HSF2BP 0.34 8.61 0.32 5.53e-17 Mean corpuscular volume; BRCA cis rs11758351 0.517 rs79958315 chr6:26221826 C/T cg01420254 chr6:26195488 NA 0.54 8.51 0.32 1.24e-16 Gout;Renal underexcretion gout; BRCA cis rs9359856 0.564 rs10484885 chr6:90395016 A/G cg13799429 chr6:90582589 CASP8AP2 -0.67 -8.56 -0.32 8.24e-17 Bipolar disorder; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 13.93 0.48 1.01e-38 Lymphocyte counts; BRCA cis rs13095912 0.785 rs35637544 chr3:185329958 A/G cg11274856 chr3:185301563 NA 0.54 13.14 0.46 4.56e-35 Systolic blood pressure; BRCA trans rs3858145 0.588 rs4142048 chr10:70044031 T/C cg04882175 chr6:131122610 NA -0.34 -7.86 -0.3 1.65e-14 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs868036 1.000 rs6494694 chr15:68057142 A/C cg08079166 chr15:68083412 MAP2K5 -0.34 -8.94 -0.33 4.17e-18 Restless legs syndrome; BRCA cis rs9393777 0.513 rs13210025 chr6:26654817 A/C cg12826209 chr6:26865740 GUSBL1 0.59 10.45 0.38 1.08e-23 Intelligence (multi-trait analysis); BRCA cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.01 0.56 8.73e-54 Morning vs. evening chronotype; BRCA cis rs9486715 0.867 rs4240553 chr6:96965324 T/C cg06623918 chr6:96969491 KIAA0776 0.9 25.83 0.71 2.76e-101 Headache; BRCA cis rs7727544 0.570 rs7701237 chr5:131534381 C/T cg14196790 chr5:131705035 SLC22A5 0.37 9.16 0.34 6.86e-19 Blood metabolite levels; BRCA cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg10523679 chr1:76189770 ACADM -0.62 -11.83 -0.42 2.38e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg14061069 chr19:46274453 DMPK -0.48 -11.84 -0.42 2.32e-29 Coronary artery disease; BRCA cis rs1707322 0.721 rs11211157 chr1:46132844 T/C cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1865721 0.771 rs727893 chr18:73136931 G/A cg26385618 chr18:73139727 C18orf62 -0.43 -10.51 -0.38 5.85e-24 Intelligence; BRCA cis rs1059312 0.500 rs10734964 chr12:129286486 C/T cg09035930 chr12:129282057 SLC15A4 0.47 11.98 0.43 5.41e-30 Systemic lupus erythematosus; BRCA cis rs7246657 0.722 rs11083432 chr19:38182633 A/G cg18154014 chr19:37997991 ZNF793 -0.45 -8.77 -0.33 1.65e-17 Coronary artery calcification; BRCA cis rs1577917 1.000 rs34581302 chr6:86705948 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -7.96 -0.3 8.09e-15 Response to antipsychotic treatment; BRCA cis rs35740288 0.929 rs11630585 chr15:86306004 C/A cg20737812 chr15:86336631 KLHL25 -0.33 -8.0 -0.3 6e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs9649213 0.593 rs62478177 chr7:97964611 G/A cg24562669 chr7:97807699 LMTK2 0.44 11.76 0.42 4.77e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs595982 0.527 rs73061659 chr19:49373556 G/A cg21252483 chr19:49399788 TULP2 -0.42 -9.36 -0.35 1.3e-19 Red cell distribution width; BRCA cis rs701145 0.878 rs187357 chr3:153958876 C/A cg17054900 chr3:154042577 DHX36 0.67 11.71 0.42 8.15e-29 Coronary artery disease; BRCA cis rs1005277 0.579 rs1780115 chr10:38524773 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.72e-15 Extrinsic epigenetic age acceleration; BRCA cis rs208520 1.000 rs12199876 chr6:66989469 A/G cg07460842 chr6:66804631 NA 0.88 14.15 0.49 1.01e-39 Exhaled nitric oxide output; BRCA cis rs9814567 1.000 rs1138273 chr3:134261437 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.82 -0.62 1.74e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2404602 0.647 rs11072612 chr15:76960984 A/T cg23625390 chr15:77176239 SCAPER -0.53 -13.09 -0.46 7.77e-35 Blood metabolite levels; BRCA cis rs200895692 1 rs200895692 chr1:43421956 CGCCTGTAATCCCAG/C cg09824328 chr1:43425412 SLC2A1 -0.52 -8.47 -0.32 1.72e-16 Monocyte count; BRCA cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.22e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs35244711 chr8:58117762 T/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs11123170 0.650 rs2289897 chr2:113977454 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.57 9.76 0.36 4.64e-21 Renal function-related traits (BUN); BRCA cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg11764359 chr7:65958608 NA 0.8 19.31 0.61 8.47e-66 Aortic root size; BRCA trans rs7395662 0.782 rs4882064 chr11:48455757 C/T cg00717180 chr2:96193071 NA 0.28 7.84 0.3 1.84e-14 HDL cholesterol; BRCA cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.31 0.31 5.87e-16 Axial length; BRCA cis rs17428076 0.514 rs3821095 chr2:172684006 A/G cg13550731 chr2:172543902 DYNC1I2 -0.52 -13.2 -0.46 2.28e-35 Myopia; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg05793240 chr7:2802953 GNA12 -0.31 -8.32 -0.31 5.48e-16 Height; BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg22907277 chr7:1156413 C7orf50 0.65 12.49 0.44 3.59e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs68170813 0.559 rs17428126 chr7:106897037 C/T cg02696742 chr7:106810147 HBP1 -0.53 -8.6 -0.32 6.15e-17 Coronary artery disease; BRCA cis rs2153535 0.580 rs2327064 chr6:8454052 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.85 0.33 8.53e-18 Motion sickness; BRCA cis rs250677 0.524 rs183140 chr5:148438803 G/T cg18129178 chr5:148520854 ABLIM3 -0.46 -9.76 -0.36 4.55e-21 Breast cancer; BRCA cis rs9487051 1.000 rs6568570 chr6:109613241 T/G cg12927641 chr6:109611667 NA -0.37 -8.98 -0.33 2.89e-18 Reticulocyte fraction of red cells; BRCA trans rs2797160 0.967 rs4897151 chr6:125993202 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.37 -8.33 -0.31 4.81e-16 Endometrial cancer; BRCA cis rs17095355 0.818 rs61881638 chr10:111863396 C/G cg00817464 chr10:111662876 XPNPEP1 -0.43 -9.13 -0.34 8.62e-19 Biliary atresia; BRCA cis rs561341 1.000 rs484175 chr17:30309041 G/A cg12193833 chr17:30244370 NA -0.54 -8.72 -0.33 2.47e-17 Hip circumference adjusted for BMI; BRCA cis rs2070488 0.699 rs13078966 chr3:38517914 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.4 0.57 8.6e-56 Electrocardiographic conduction measures; BRCA cis rs72627123 0.867 rs17093884 chr14:74482039 A/G cg12022184 chr14:74485813 ENTPD5;C14orf45 0.68 8.1 0.31 2.87e-15 Morning vs. evening chronotype; BRCA cis rs7772486 0.764 rs7762562 chr6:146158994 T/C cg23711669 chr6:146136114 FBXO30 0.79 19.31 0.61 8.9e-66 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.517 rs11052964 chr12:34010996 G/C cg13010199 chr12:38710504 ALG10B 0.48 9.08 0.34 1.39e-18 Morning vs. evening chronotype; BRCA cis rs36051895 0.695 rs11794778 chr9:5023794 G/T cg02405213 chr9:5042618 JAK2 -0.5 -8.78 -0.33 1.45e-17 Pediatric autoimmune diseases; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg00149659 chr3:10157352 C3orf10 0.75 12.66 0.45 6.36e-33 Alzheimer's disease; BRCA cis rs28830936 0.966 rs1918310 chr15:42065253 A/C cg17847044 chr15:42102381 MAPKBP1 -0.34 -9.71 -0.36 6.97e-21 Diastolic blood pressure; BRCA cis rs1395 0.744 rs11126934 chr2:27476613 T/C cg23587288 chr2:27483067 SLC30A3 -0.38 -8.96 -0.33 3.44e-18 Blood metabolite levels; BRCA cis rs6545883 0.929 rs12612982 chr2:61747355 G/A cg15711740 chr2:61764176 XPO1 -0.54 -13.82 -0.48 3.34e-38 Tuberculosis; BRCA trans rs57046232 0.552 rs1887412 chr20:6340856 A/G cg21095983 chr6:86352623 SYNCRIP 0.38 7.97 0.3 7.18e-15 Colorectal cancer; BRCA cis rs2652834 1.000 rs2652838 chr15:63396088 A/G cg05507819 chr15:63340323 TPM1 0.45 8.39 0.32 3.12e-16 HDL cholesterol; BRCA cis rs4478858 0.735 rs11576621 chr1:31795460 A/G cg00250761 chr1:31883323 NA -0.32 -8.51 -0.32 1.2e-16 Alcohol dependence; BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg04013093 chr6:42928303 GNMT -0.28 -8.82 -0.33 1.07e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4975709 0.589 rs1466606 chr5:1865055 C/T cg20790798 chr5:1857306 NA -0.38 -8.88 -0.33 6.48e-18 Cardiovascular disease risk factors; BRCA cis rs11098499 0.738 rs34965784 chr4:120361586 G/C cg09307838 chr4:120376055 NA 0.74 16.18 0.54 1.34e-49 Corneal astigmatism; BRCA cis rs12200782 0.505 rs9295696 chr6:26550288 C/T cg11502198 chr6:26597334 ABT1 0.66 10.74 0.39 7.63e-25 Small cell lung carcinoma; BRCA cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg11890956 chr21:40555474 PSMG1 -1.06 -31.65 -0.78 5.61e-133 Cognitive function; BRCA cis rs6088580 0.524 rs6088560 chr20:33228549 T/C cg08999081 chr20:33150536 PIGU -0.33 -8.71 -0.33 2.57e-17 Glomerular filtration rate (creatinine); BRCA cis rs67460515 0.563 rs11713441 chr3:160906855 T/C cg17135325 chr3:160939158 NMD3 0.45 8.58 0.32 7.26e-17 Parkinson's disease; BRCA cis rs9487051 0.872 rs9400271 chr6:109607556 G/A cg01475377 chr6:109611718 NA -0.59 -16.55 -0.55 1.79e-51 Reticulocyte fraction of red cells; BRCA cis rs40363 0.645 rs250629 chr16:3525431 C/A cg21433313 chr16:3507492 NAT15 0.45 9.98 0.37 6.9e-22 Tuberculosis; BRCA cis rs2386661 0.547 rs72781996 chr10:5646485 C/G cg17085576 chr10:5658249 NA -0.33 -8.25 -0.31 9.17e-16 Breast cancer; BRCA cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.46 7.98 0.3 6.92e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12479064 0.724 rs3792143 chr2:100057020 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.49 -9.58 -0.35 2.15e-20 Chronic sinus infection; BRCA trans rs1459104 1.000 rs35218816 chr11:55087104 C/A cg03929089 chr4:120376271 NA 0.65 7.9 0.3 1.25e-14 Body mass index; BRCA trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.22 0.54 8.5e-50 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.897 rs2836973 chr21:40654928 A/G cg11890956 chr21:40555474 PSMG1 1.07 32.4 0.79 5.59e-137 Cognitive function; BRCA trans rs7726839 0.561 rs4957050 chr5:579066 A/C cg25482853 chr8:67687455 SGK3 0.78 13.07 0.46 8.85e-35 Obesity-related traits; BRCA cis rs10504229 0.728 rs72650853 chr8:58151473 G/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs7568458 0.846 rs7605975 chr2:85772548 C/T cg17127132 chr2:85788382 GGCX 0.35 8.0 0.3 5.72e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs6479891 1.000 rs10995506 chr10:65094466 A/G cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs9486715 0.830 rs4425602 chr6:96893906 G/A cg06623918 chr6:96969491 KIAA0776 0.89 25.59 0.71 6.04e-100 Headache; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg24846343 chr22:24311635 DDTL 0.4 9.71 0.36 7.2e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1167827 0.680 rs1167796 chr7:75173180 C/T cg04978709 chr7:75101039 POM121C -0.35 -9.17 -0.34 6.38e-19 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72781680 0.611 rs56326157 chr2:24312407 T/C cg08917208 chr2:24149416 ATAD2B 0.55 8.37 0.31 3.64e-16 Lymphocyte counts; BRCA cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg09469691 chr10:81107165 PPIF 0.51 11.08 0.4 3.27e-26 Height; BRCA cis rs4555082 0.957 rs2816627 chr14:105736109 A/G cg06808227 chr14:105710500 BRF1 -0.75 -15.52 -0.52 2.61e-46 Mean platelet volume;Platelet distribution width; BRCA cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs3808502 0.527 rs2736374 chr8:11113828 A/G cg21775007 chr8:11205619 TDH -0.39 -7.95 -0.3 8.36e-15 Neuroticism; BRCA cis rs933688 0.938 rs7708782 chr5:90718517 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.91 19.95 0.62 3.19e-69 Smoking behavior; BRCA cis rs2762353 0.935 rs1165209 chr6:25801319 G/A cg03264133 chr6:25882463 NA -0.48 -10.85 -0.39 2.68e-25 Blood metabolite levels; BRCA cis rs4819052 0.851 rs9974628 chr21:46672647 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.09 0.49 1.91e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs72781680 0.611 rs36052574 chr2:24306587 A/C cg08917208 chr2:24149416 ATAD2B 0.56 8.61 0.32 5.89e-17 Lymphocyte counts; BRCA cis rs34779708 0.966 rs4934732 chr10:35431684 T/C cg03585969 chr10:35415529 CREM 0.49 10.36 0.38 2.31e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2115536 1.000 rs2115536 chr15:80194247 C/T cg00225070 chr15:80189496 MTHFS 0.4 9.41 0.35 8.55e-20 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg02951883 chr7:2050386 MAD1L1 -0.61 -15.14 -0.51 1.71e-44 Bipolar disorder and schizophrenia; BRCA cis rs72781680 0.898 rs72782136 chr2:24047344 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.11 0.34 1.04e-18 Lymphocyte counts; BRCA trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg15934090 chr1:100435551 SLC35A3 0.37 8.56 0.32 8.42e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs372883 0.648 rs2832296 chr21:30741454 C/T cg08807101 chr21:30365312 RNF160 -0.42 -8.9 -0.33 5.57e-18 Pancreatic cancer; BRCA cis rs1059312 0.808 rs12831705 chr12:129294905 G/A cg09035930 chr12:129282057 SLC15A4 0.51 14.56 0.5 1.13e-41 Systemic lupus erythematosus; BRCA cis rs10870270 0.913 rs115236491 chr10:133766855 T/G cg17892150 chr10:133769511 PPP2R2D -0.72 -15.51 -0.52 2.66e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg04972856 chr6:88032051 C6orf162;GJB7 0.31 8.18 0.31 1.56e-15 Monocyte percentage of white cells; BRCA cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.71e-15 Uric acid levels; BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg22920501 chr2:26401640 FAM59B 0.95 16.82 0.55 7.55e-53 Gut microbiome composition (summer); BRCA cis rs1552244 0.572 rs3894323 chr3:10168967 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -9.11 -0.34 1.06e-18 Alzheimer's disease; BRCA cis rs28374715 0.528 rs7178360 chr15:41631175 T/A cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.8 -0.71 4.21e-101 Ulcerative colitis; BRCA trans rs877282 0.945 rs10904550 chr10:774177 C/T cg22713356 chr15:30763199 NA 1.18 24.01 0.69 2.83e-91 Uric acid levels; BRCA cis rs7267979 0.764 rs2474767 chr20:25246733 T/C cg08601574 chr20:25228251 PYGB 0.34 8.08 0.3 3.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs847577 0.609 rs11763970 chr7:97817321 A/G cg21770322 chr7:97807741 LMTK2 0.64 19.15 0.6 5.86e-65 Breast cancer; BRCA cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg22105103 chr4:187893119 NA -0.4 -12.1 -0.43 1.64e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs9393023 chr6:8469994 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs3849570 1.000 rs11711331 chr3:81819040 A/G cg07356753 chr3:81810745 GBE1 0.46 11.16 0.4 1.52e-26 Waist circumference;Body mass index; BRCA cis rs2197308 0.605 rs2387437 chr12:37919367 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.34 0.31 4.59e-16 Morning vs. evening chronotype; BRCA cis rs72781680 0.898 rs72786279 chr2:24063266 C/T cg08917208 chr2:24149416 ATAD2B 0.92 13.6 0.47 3.66e-37 Lymphocyte counts; BRCA trans rs225245 0.817 rs225255 chr17:33955243 A/G cg19694781 chr19:47549865 TMEM160 0.32 7.85 0.3 1.8e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs1552244 0.935 rs4441636 chr3:10083876 G/A cg08888203 chr3:10149979 C3orf24 0.66 14.05 0.49 2.73e-39 Alzheimer's disease; BRCA cis rs9443645 0.901 rs7742034 chr6:79737106 A/G cg09184832 chr6:79620586 NA -0.54 -11.87 -0.43 1.65e-29 Intelligence (multi-trait analysis); BRCA cis rs3760982 0.565 rs3786956 chr19:44286829 C/T cg11993925 chr19:44307056 LYPD5 0.45 10.42 0.38 1.42e-23 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs477692 1.000 rs477692 chr10:131426022 T/C cg05714579 chr10:131428358 MGMT 0.59 14.4 0.49 6.55e-41 Response to temozolomide; BRCA cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg11644478 chr21:40555479 PSMG1 0.66 14.68 0.5 3.02e-42 Cognitive function; BRCA cis rs4363385 0.747 rs4323653 chr1:152983359 T/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.9 -0.36 1.41e-21 Inflammatory skin disease; BRCA cis rs6842047 1.000 rs10471184 chr4:187122904 C/T cg23442198 chr4:187126114 CYP4V2 -0.9 -11.23 -0.41 7.71e-27 Blood protein levels; BRCA cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg18479299 chr3:125709523 NA -0.54 -8.33 -0.31 4.84e-16 Blood pressure (smoking interaction); BRCA cis rs55882075 0.730 rs10794700 chr5:179148335 C/G cg14593053 chr5:179126677 CANX 0.48 12.75 0.45 2.51e-33 Monocyte percentage of white cells; BRCA cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg25358565 chr5:93447407 FAM172A 1.21 18.37 0.59 7.73e-61 Diabetic retinopathy; BRCA cis rs9487051 0.933 rs5005289 chr6:109617673 C/G cg21918786 chr6:109611834 NA -0.43 -11.79 -0.42 3.56e-29 Reticulocyte fraction of red cells; BRCA cis rs7903847 0.642 rs1537645 chr10:99149914 T/C cg20016023 chr10:99160130 RRP12 -0.26 -8.55 -0.32 9.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs1153858 0.943 rs67045941 chr15:45677011 A/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.72 0.42 7.51e-29 Homoarginine levels; BRCA trans rs9784649 0.760 rs72755820 chr5:25066181 G/A cg08600765 chr20:34638493 LOC647979 -0.63 -10.54 -0.38 4.86e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs17253792 0.732 rs8017891 chr14:56172967 A/G cg01858014 chr14:56050164 KTN1 0.56 9.0 0.34 2.55e-18 Putamen volume; BRCA cis rs9381040 0.610 rs2057002 chr6:41022962 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.95 -0.33 3.7e-18 Alzheimer's disease (late onset); BRCA cis rs10504229 1.000 rs6987435 chr8:58177334 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.5 -0.44 2.98e-32 Developmental language disorder (linguistic errors); BRCA trans rs2262909 0.925 rs404822 chr19:22215967 A/C cg17074339 chr11:11642133 GALNTL4 -0.41 -7.81 -0.3 2.39e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs858239 0.676 rs274032 chr7:23374559 C/G cg23682824 chr7:23144976 KLHL7 0.36 8.69 0.33 3.02e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs709400 0.597 rs1013650 chr14:103909203 G/A cg12935359 chr14:103987150 CKB -0.59 -14.22 -0.49 4.73e-40 Body mass index; BRCA cis rs637571 0.522 rs556643 chr11:65733289 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.38 9.14 0.34 8.42e-19 Eosinophil percentage of white cells; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg04025307 chr7:1156635 C7orf50 0.59 9.46 0.35 5.6e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs67340775 0.541 rs200965 chr6:27866384 G/A cg26587870 chr6:27730563 NA -0.47 -8.25 -0.31 9.15e-16 Lung cancer in ever smokers; BRCA cis rs1862618 0.671 rs2591955 chr5:56244948 C/T cg18230493 chr5:56204884 C5orf35 0.62 13.04 0.46 1.3e-34 Initial pursuit acceleration; BRCA cis rs6570726 0.837 rs419991 chr6:145864212 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.65 0.5 4.22e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs3815700 1.000 rs8101356 chr19:33093402 C/T cg02997394 chr19:33096574 ANKRD27 0.69 11.52 0.41 4.75e-28 Eosinophilic esophagitis; BRCA trans rs8073060 0.586 rs72829923 chr17:34045089 T/A cg19694781 chr19:47549865 TMEM160 1.07 20.64 0.63 6.34e-73 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7833986 0.501 rs2667978 chr8:56897951 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.57 11.03 0.4 5.18e-26 Height; BRCA cis rs12545109 0.800 rs2576599 chr8:57388410 G/A cg09654669 chr8:57350985 NA -0.42 -8.16 -0.31 1.72e-15 Obesity-related traits; BRCA cis rs6570726 0.791 rs1280276 chr6:145892350 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -9.2 -0.34 5.12e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs7737355 1.000 rs59808242 chr5:130754894 G/A cg06307176 chr5:131281290 NA -0.51 -9.97 -0.37 7.4e-22 Life satisfaction; BRCA cis rs17641971 0.645 rs10504073 chr8:50024944 C/T cg00325661 chr8:49890786 NA 0.36 10.1 0.37 2.28e-22 Blood metabolite levels; BRCA cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg13334819 chr7:99746414 C7orf59 -0.41 -9.79 -0.36 3.38e-21 Coronary artery disease; BRCA cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg04025307 chr7:1156635 C7orf50 0.46 9.19 0.34 5.44e-19 Bronchopulmonary dysplasia; BRCA cis rs11758351 1.000 rs1341759 chr6:26195502 G/A cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs1577917 1.000 rs1911553 chr6:86630892 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.07 -0.43 2.24e-30 Response to antipsychotic treatment; BRCA cis rs858239 0.601 rs2068459 chr7:23154313 A/C cg23682824 chr7:23144976 KLHL7 0.4 10.42 0.38 1.42e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs10267417 0.603 rs10267511 chr7:19896924 A/G cg07541023 chr7:19748670 TWISTNB 0.46 8.31 0.31 5.72e-16 Night sleep phenotypes; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg15112475 chr7:1198522 ZFAND2A -0.39 -8.36 -0.31 4.07e-16 Longevity;Endometriosis; BRCA trans rs1997103 1.000 rs4947499 chr7:55407196 T/C cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs250677 0.522 rs6580590 chr5:148360374 C/T cg18129178 chr5:148520854 ABLIM3 0.54 10.41 0.38 1.57e-23 Breast cancer; BRCA cis rs10504229 0.953 rs17805380 chr8:58171128 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs9309473 0.632 rs6706179 chr2:73578577 C/T cg20560298 chr2:73613845 ALMS1 -0.42 -10.87 -0.4 2.17e-25 Metabolite levels; BRCA cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg13010199 chr12:38710504 ALG10B 0.35 8.6 0.32 6.06e-17 Morning vs. evening chronotype; BRCA cis rs9309711 0.544 rs9309712 chr2:3491327 G/T cg10845886 chr2:3471009 TTC15 -0.47 -9.74 -0.36 5.17e-21 Neurofibrillary tangles; BRCA cis rs11098499 0.865 rs9994730 chr4:120381564 A/C cg09307838 chr4:120376055 NA 0.72 15.37 0.52 1.35e-45 Corneal astigmatism; BRCA cis rs6088580 0.634 rs6058070 chr20:33103521 G/C cg24642439 chr20:33292090 TP53INP2 0.52 11.43 0.41 1.2e-27 Glomerular filtration rate (creatinine); BRCA cis rs8177253 0.898 rs8177258 chr3:133480387 C/A cg08048268 chr3:133502702 NA -0.33 -8.24 -0.31 9.47e-16 Iron status biomarkers; BRCA trans rs62103177 0.525 rs612913 chr18:77845882 A/G cg05926928 chr17:57297772 GDPD1 -0.76 -10.8 -0.39 4.27e-25 Opioid sensitivity; BRCA cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.32e-32 Developmental language disorder (linguistic errors); BRCA trans rs11098499 1.000 rs28374891 chr4:120183550 G/A cg25214090 chr10:38739885 LOC399744 0.48 10.53 0.38 5e-24 Corneal astigmatism; BRCA cis rs1707322 0.929 rs785513 chr1:46538320 T/C cg06784218 chr1:46089804 CCDC17 -0.45 -10.63 -0.39 2e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11252926 0.897 rs7092330 chr10:583771 G/C cg18196295 chr10:418757 DIP2C -0.45 -9.88 -0.36 1.66e-21 Psychosis in Alzheimer's disease; BRCA cis rs2535633 0.631 rs6799185 chr3:53101580 C/T cg11645453 chr3:52864694 ITIH4 0.3 7.85 0.3 1.8e-14 Body mass index; BRCA cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg12863693 chr15:85201151 NMB -0.4 -9.4 -0.35 9.82e-20 P wave terminal force; BRCA cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg06618935 chr21:46677482 NA -0.37 -8.17 -0.31 1.65e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg20790798 chr5:1857306 NA -0.4 -9.27 -0.34 2.75e-19 Cardiovascular disease risk factors; BRCA cis rs2153535 0.580 rs1577468 chr6:8444266 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs1577917 0.958 rs12207374 chr6:86656645 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.87 -0.43 1.6e-29 Response to antipsychotic treatment; BRCA cis rs6815814 0.904 rs7664239 chr4:38786304 T/C cg06935464 chr4:38784597 TLR10 0.48 9.6 0.36 1.75e-20 Breast cancer; BRCA trans rs7824557 0.767 rs3808513 chr8:11157460 G/T cg08975724 chr8:8085496 FLJ10661 -0.42 -8.01 -0.3 5.54e-15 Retinal vascular caliber; BRCA cis rs7819412 0.521 rs10100660 chr8:11038885 T/A cg21775007 chr8:11205619 TDH -0.51 -10.01 -0.37 5.14e-22 Triglycerides; BRCA cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg16339924 chr4:17578868 LAP3 0.6 14.74 0.5 1.48e-42 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9341808 0.714 rs9448911 chr6:80913859 A/G cg08355045 chr6:80787529 NA 0.32 8.04 0.3 4.2e-15 Sitting height ratio; BRCA cis rs992157 0.710 rs6719789 chr2:219057810 G/T cg00012203 chr2:219082015 ARPC2 -0.63 -13.62 -0.47 2.78e-37 Colorectal cancer; BRCA trans rs3942852 0.806 rs10769316 chr11:48119745 C/G cg15704280 chr7:45808275 SEPT13 -0.47 -9.07 -0.34 1.43e-18 Acute lymphoblastic leukemia (childhood); BRCA trans rs12517041 1.000 rs1428621 chr5:23283431 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg13010199 chr12:38710504 ALG10B 0.43 9.16 0.34 6.75e-19 Morning vs. evening chronotype; BRCA cis rs2404602 0.716 rs12441247 chr15:76812316 T/C cg23625390 chr15:77176239 SCAPER 0.39 9.23 0.34 3.88e-19 Blood metabolite levels; BRCA cis rs7119038 0.629 rs10892272 chr11:118602707 C/G cg19308663 chr11:118741387 NA 0.33 8.28 0.31 7.45e-16 Sjögren's syndrome; BRCA cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg11644478 chr21:40555479 PSMG1 0.81 18.09 0.58 2.26e-59 Cognitive function; BRCA cis rs4891159 0.505 rs680253 chr18:74167427 A/C cg24786174 chr18:74118243 ZNF516 -0.74 -20.26 -0.63 7.38e-71 Longevity; BRCA cis rs1499614 0.831 rs3800822 chr7:66147149 A/G cg18252515 chr7:66147081 NA 1.07 15.95 0.53 1.77e-48 Gout; BRCA cis rs4690686 0.538 rs10520346 chr4:177259088 C/G cg17059388 chr4:177262070 NA 0.49 9.9 0.36 1.33e-21 Essential tremor; BRCA cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -8.0 -0.3 6.08e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17376456 0.877 rs7728736 chr5:93404277 C/T cg25358565 chr5:93447407 FAM172A 1.17 18.51 0.59 1.49e-61 Diabetic retinopathy; BRCA cis rs6120849 0.586 rs2025096 chr20:33540000 G/A cg24642439 chr20:33292090 TP53INP2 0.6 10.35 0.38 2.5e-23 Protein C levels; BRCA cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs4073582 0.595 rs801741 chr11:65917084 A/G cg16950941 chr11:66035639 RAB1B 0.43 11.55 0.42 3.66e-28 Gout; BRCA cis rs72634258 0.945 rs12748993 chr1:8129507 A/G cg00042356 chr1:8021962 PARK7 0.73 11.71 0.42 8.12e-29 Inflammatory bowel disease; BRCA cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg17971929 chr21:40555470 PSMG1 0.77 18.05 0.58 3.77e-59 Cognitive function; BRCA cis rs4363385 0.818 rs409986 chr1:153014741 A/C cg25856811 chr1:152973957 SPRR3 0.32 8.33 0.31 4.9e-16 Inflammatory skin disease; BRCA cis rs1008375 0.966 rs10489036 chr4:17697687 A/G cg15017067 chr4:17643749 FAM184B 0.27 8.22 0.31 1.15e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs877282 0.898 rs12354872 chr10:763362 G/A cg22713356 chr15:30763199 NA 1.31 24.8 0.7 1.26e-95 Uric acid levels; BRCA trans rs11039798 0.920 rs116109043 chr11:48976940 C/T cg15704280 chr7:45808275 SEPT13 0.6 8.93 0.33 4.6e-18 Axial length; BRCA cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.79 19.16 0.6 5.3e-65 Multiple sclerosis; BRCA cis rs473651 0.777 rs550890 chr2:239332555 G/A cg21699342 chr2:239360505 ASB1 0.47 11.16 0.4 1.58e-26 Multiple system atrophy; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.16 -0.34 6.74e-19 Total body bone mineral density; BRCA cis rs651907 0.535 rs61396602 chr3:101509046 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.32 0.49 1.58e-40 Colorectal cancer; BRCA cis rs561341 1.000 rs8073186 chr17:30244956 T/C cg23018236 chr17:30244563 NA -0.52 -9.47 -0.35 5.47e-20 Hip circumference adjusted for BMI; BRCA cis rs9790314 0.846 rs1478568 chr3:161014276 C/T cg03342759 chr3:160939853 NMD3 -0.68 -15.72 -0.53 2.69e-47 Morning vs. evening chronotype; BRCA cis rs11229555 0.609 rs7928676 chr11:58188022 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs3784262 0.669 rs4646626 chr15:58256127 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.03 -0.37 4.51e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4665809 1.000 rs12475854 chr2:26267375 G/A cg04944784 chr2:26401820 FAM59B -0.66 -11.26 -0.41 5.91e-27 Gut microbiome composition (summer); BRCA cis rs9818758 0.607 rs13068038 chr3:49294250 C/A cg00383909 chr3:49044727 WDR6 0.77 13.03 0.46 1.34e-34 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1707322 0.963 rs10890371 chr1:46390897 T/G cg06784218 chr1:46089804 CCDC17 0.45 10.7 0.39 1.08e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs72781680 0.898 rs6712175 chr2:24023431 T/G cg20701182 chr2:24300061 SF3B14 0.56 8.58 0.32 7.27e-17 Lymphocyte counts; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg22903471 chr2:27725779 GCKR -0.36 -8.73 -0.33 2.29e-17 Total body bone mineral density; BRCA cis rs12579753 0.956 rs34146892 chr12:82188581 T/G cg07988820 chr12:82153109 PPFIA2 -0.61 -9.86 -0.36 1.85e-21 Resting heart rate; BRCA trans rs1997103 1.000 rs4947503 chr7:55409427 G/T cg20935933 chr6:143382018 AIG1 0.61 11.73 0.42 6.24e-29 QRS interval (sulfonylurea treatment interaction); BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg21143896 chr7:2802374 GNA12 -0.34 -8.32 -0.31 5.22e-16 Height; BRCA cis rs9875589 0.509 rs4684174 chr3:14048375 C/T cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.82 0.33 1.1e-17 Ovarian reserve; BRCA cis rs3008870 0.959 rs2985816 chr1:67387750 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.74 0.65 7.41e-79 Lymphocyte percentage of white cells; BRCA cis rs1018836 0.798 rs28568272 chr8:91652958 A/G cg16814680 chr8:91681699 NA -0.74 -16.87 -0.56 4.29e-53 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs4742903 0.967 rs10125661 chr9:106868443 A/G cg14250997 chr9:106856677 SMC2 0.34 10.96 0.4 1e-25 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs4713118 0.666 rs4140646 chr6:27738801 G/A cg20933634 chr6:27740509 NA 0.47 8.87 0.33 7.41e-18 Parkinson's disease; BRCA cis rs2070433 0.556 rs8129460 chr21:47822544 C/T cg12379764 chr21:47803548 PCNT 0.55 10.19 0.37 1.03e-22 Lymphocyte counts; BRCA cis rs6860806 0.507 rs274570 chr5:131713226 C/T cg24060327 chr5:131705240 SLC22A5 0.6 11.06 0.4 3.91e-26 Breast cancer; BRCA cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg02556042 chr12:117471086 NA -0.57 -10.02 -0.37 4.63e-22 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs425277 0.916 rs414777 chr1:2101687 G/A cg24578937 chr1:2090814 PRKCZ 0.58 17.99 0.58 7.63e-59 Height; BRCA cis rs6543140 0.964 rs11903551 chr2:103084181 C/G cg04239558 chr2:103089729 SLC9A4 0.35 9.89 0.36 1.52e-21 Blood protein levels; BRCA cis rs769267 0.965 rs2965198 chr19:19473030 A/G cg03709012 chr19:19516395 GATAD2A -0.8 -18.12 -0.58 1.59e-59 Tonsillectomy; BRCA cis rs7714584 1.000 rs12652003 chr5:150231945 T/C cg22134413 chr5:150180641 NA 0.69 10.38 0.38 1.94e-23 Crohn's disease; BRCA cis rs17767294 0.708 rs72848752 chr6:27878268 A/C cg08851530 chr6:28072375 NA 0.75 7.86 0.3 1.61e-14 Parkinson's disease; BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -12.92 -0.46 4.19e-34 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4953076 0.574 rs4953074 chr2:44464629 C/T cg04920474 chr2:44395004 PPM1B 0.54 11.56 0.42 3.46e-28 Height; BRCA cis rs861020 1.000 rs12134698 chr1:209987801 C/A cg09163369 chr1:210001066 C1orf107 -0.52 -9.64 -0.36 1.28e-20 Orofacial clefts; BRCA cis rs7191700 1.000 rs7191700 chr16:11406803 C/T cg00044050 chr16:11439710 C16orf75 0.39 8.12 0.31 2.39e-15 Multiple sclerosis; BRCA cis rs10540 1.000 rs12418639 chr11:473300 A/C cg15790184 chr11:494944 RNH1 -0.66 -9.97 -0.37 7.58e-22 Body mass index; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs6429082 0.967 rs834143 chr1:235626406 C/T cg26050004 chr1:235667680 B3GALNT2 0.39 9.58 0.35 2.05e-20 Adiposity; BRCA cis rs3806843 0.932 rs2563257 chr5:140140529 A/G cg16179182 chr5:140090404 VTRNA1-1 0.42 9.54 0.35 3e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs8180040 0.966 rs2062278 chr3:47416761 C/T cg27129171 chr3:47204927 SETD2 0.64 14.81 0.51 7.22e-43 Colorectal cancer; BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.48 9.87 0.36 1.77e-21 Tonsillectomy; BRCA cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg12011299 chr4:100065546 ADH4 0.42 10.5 0.38 6.88e-24 Alcohol dependence; BRCA cis rs2204008 0.683 rs11519834 chr12:38053575 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 2.99e-22 Bladder cancer; BRCA cis rs477895 0.938 rs28395875 chr11:64024048 G/C cg04317338 chr11:64019027 PLCB3 0.52 7.98 0.3 7.04e-15 Mean platelet volume; BRCA cis rs7267979 0.933 rs6138571 chr20:25435388 A/G cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1003719 0.645 rs8131944 chr21:38547215 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs1595825 0.891 rs16867018 chr2:198521490 C/T cg19156104 chr2:198669113 PLCL1 -0.42 -8.15 -0.31 1.91e-15 Ulcerative colitis; BRCA cis rs4319547 0.698 rs10744217 chr12:122942070 A/G cg05707623 chr12:122985044 ZCCHC8 -0.43 -8.76 -0.33 1.73e-17 Body mass index; BRCA cis rs2576037 0.899 rs2576035 chr18:44587654 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.43 8.76 0.33 1.71e-17 Personality dimensions; BRCA cis rs826838 1.000 rs10506122 chr12:38699232 A/G cg26384229 chr12:38710491 ALG10B 0.87 23.81 0.69 3.35e-90 Heart rate; BRCA cis rs2130392 1.000 rs873686 chr4:185638876 A/G cg04058563 chr4:185651563 MLF1IP -0.35 -8.73 -0.33 2.17e-17 Kawasaki disease; BRCA cis rs4253772 0.550 rs9615347 chr22:46728153 A/G cg24881330 chr22:46731750 TRMU 0.7 8.0 0.3 5.91e-15 LDL cholesterol;Cholesterol, total; BRCA cis rs514406 0.621 rs2003250 chr1:53196666 T/C cg08859206 chr1:53392774 SCP2 0.42 8.31 0.31 5.65e-16 Monocyte count; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg26119090 chr2:26468346 HADHA;HADHB -1.06 -23.08 -0.67 3.67e-86 Gut microbiome composition (summer); BRCA cis rs312274 0.550 rs11178982 chr12:41301332 A/G cg17827154 chr12:41323612 CNTN1 -0.41 -10.39 -0.38 1.73e-23 Metabolite levels (X-11787); BRCA cis rs2197308 0.549 rs10785517 chr12:38577992 G/T cg26384229 chr12:38710491 ALG10B 0.42 9.94 0.37 1e-21 Morning vs. evening chronotype; BRCA cis rs9473147 0.571 rs9463335 chr6:47479136 G/A cg12968598 chr6:47444699 CD2AP 0.46 9.91 0.36 1.28e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs7493 1.000 rs2158806 chr7:95051998 A/C cg19678392 chr7:94953810 PON1 -0.42 -8.67 -0.32 3.47e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4363385 0.693 rs576941 chr1:153040165 A/G cg24667326 chr1:152973720 SPRR3 0.3 8.06 0.3 3.89e-15 Inflammatory skin disease; BRCA cis rs925228 0.504 rs6755030 chr2:24318343 C/T cg01493198 chr2:24299560 SF3B14 0.6 9.63 0.36 1.34e-20 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs495337 1.000 rs4287819 chr20:48551956 T/G cg17835207 chr20:48524531 SPATA2 -0.64 -15.1 -0.51 2.82e-44 Psoriasis; BRCA cis rs4742903 0.967 rs6479215 chr9:106885243 A/G cg21169611 chr9:106856078 SMC2 -0.38 -10.05 -0.37 3.66e-22 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs4975616 0.773 rs10078017 chr5:1314009 C/T cg06550200 chr5:1325588 CLPTM1L 0.56 11.3 0.41 4.17e-27 Lung cancer; BRCA cis rs17641971 0.708 rs2137013 chr8:49981091 C/T cg00325661 chr8:49890786 NA 0.38 10.52 0.38 5.49e-24 Blood metabolite levels; BRCA trans rs10411161 0.702 rs10424202 chr19:52387297 G/A cg22319618 chr22:45562946 NUP50 -0.43 -8.01 -0.3 5.43e-15 Breast cancer; BRCA cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg06115741 chr20:33292138 TP53INP2 0.4 8.85 0.33 8.31e-18 Coronary artery disease; BRCA cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg27286337 chr10:134555280 INPP5A 0.64 10.63 0.39 2.13e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7824557 0.652 rs12677504 chr8:11133175 G/A cg21775007 chr8:11205619 TDH -0.61 -12.04 -0.43 3.16e-30 Retinal vascular caliber; BRCA cis rs10504229 0.683 rs16921843 chr8:58113338 T/C cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs17601876 0.843 rs17523541 chr15:51554844 G/A cg19946085 chr15:51559439 CYP19A1 -0.38 -11.08 -0.4 3.13e-26 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA trans rs61931739 0.517 rs11513519 chr12:34075077 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.38 0.35 1.15e-19 Morning vs. evening chronotype; BRCA cis rs2066819 1.000 rs77131854 chr12:56664231 C/T cg26714650 chr12:56694279 CS -1.16 -15.21 -0.52 8.38e-45 Psoriasis vulgaris; BRCA cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg01475377 chr6:109611718 NA -0.6 -16.64 -0.55 6.5e-52 Reticulocyte fraction of red cells; BRCA trans rs11098499 0.863 rs12508173 chr4:120318526 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.01 0.3 5.51e-15 Corneal astigmatism; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg22907277 chr7:1156413 C7orf50 0.49 11.95 0.43 7.3e-30 Longevity;Endometriosis; BRCA cis rs11190604 0.767 rs4919459 chr10:102200371 C/T cg07080220 chr10:102295463 HIF1AN 0.44 9.67 0.36 9.41e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2559856 1.000 rs2559857 chr12:102089399 A/C cg12924262 chr12:102091054 CHPT1 0.38 8.65 0.32 4.28e-17 Blood protein levels; BRCA cis rs561341 1.000 rs555629 chr17:30294136 T/C cg00745463 chr17:30367425 LRRC37B -0.53 -8.91 -0.33 5.36e-18 Hip circumference adjusted for BMI; BRCA cis rs4780401 0.728 rs6498239 chr16:11780774 T/C cg01061890 chr16:11836724 TXNDC11 -0.41 -9.02 -0.34 2.26e-18 Rheumatoid arthritis; BRCA cis rs11690935 1.000 rs3795999 chr2:172544483 A/G cg13550731 chr2:172543902 DYNC1I2 0.93 30.67 0.77 1.14e-127 Schizophrenia; BRCA cis rs9486719 0.947 rs12194971 chr6:96911073 T/C cg06623918 chr6:96969491 KIAA0776 -0.73 -13.11 -0.46 6.04e-35 Migraine;Coronary artery disease; BRCA cis rs3857536 0.605 rs36040831 chr6:66876588 G/A cg07460842 chr6:66804631 NA -0.66 -14.51 -0.5 1.84e-41 Blood trace element (Cu levels); BRCA cis rs3824867 0.920 rs7111873 chr11:47469439 A/G cg20307385 chr11:47447363 PSMC3 0.51 11.52 0.41 4.99e-28 Mean corpuscular hemoglobin; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg00106254 chr7:1943704 MAD1L1 -0.39 -9.6 -0.36 1.72e-20 Bipolar disorder and schizophrenia; BRCA cis rs3862030 0.720 rs7081110 chr10:104231651 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.11e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA trans rs1945213 0.694 rs11227113 chr11:55828024 C/T cg15704280 chr7:45808275 SEPT13 0.63 10.89 0.4 1.85e-25 Acute lymphoblastic leukemia (childhood); BRCA cis rs6684514 1.000 rs10908502 chr1:156300082 A/G cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9527 0.525 rs12770034 chr10:104635595 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.31 0.38 3.84e-23 Arsenic metabolism; BRCA cis rs2836633 0.929 rs62217518 chr21:40033189 T/G cg05519781 chr21:40033154 ERG 0.46 9.83 0.36 2.38e-21 Coronary artery disease; BRCA cis rs9837602 0.810 rs35885423 chr3:99813218 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.3e-26 Breast cancer; BRCA cis rs2303759 1.000 rs2303759 chr19:49869051 T/G cg22590775 chr19:49891494 CCDC155 0.45 8.13 0.31 2.24e-15 Multiple sclerosis; BRCA cis rs950169 0.614 rs765524 chr15:84681782 G/T cg17507749 chr15:85114479 UBE2QP1 0.52 8.76 0.33 1.81e-17 Schizophrenia; BRCA cis rs8062405 0.824 rs4788083 chr16:28545449 A/G cg16576597 chr16:28551801 NUPR1 0.28 7.98 0.3 6.87e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7246657 0.943 rs7255972 chr19:37933841 T/C cg23950597 chr19:37808831 NA -0.74 -13.06 -0.46 1.05e-34 Coronary artery calcification; BRCA cis rs7666738 0.716 rs6817529 chr4:99023213 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.874 rs17839089 chr4:120111069 A/G cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.65e-26 Corneal astigmatism; BRCA cis rs6723226 0.750 rs1033751 chr2:32695759 T/C cg02381751 chr2:32503542 YIPF4 0.47 10.02 0.37 4.93e-22 Intelligence (multi-trait analysis); BRCA cis rs2742417 0.624 rs2742394 chr3:45757591 C/T cg04837898 chr3:45731254 SACM1L -0.4 -8.15 -0.31 1.87e-15 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs4268898 0.516 rs7597149 chr2:24371962 C/T cg26838691 chr2:24397539 C2orf84 0.4 8.16 0.31 1.75e-15 Asthma; BRCA cis rs2576037 0.526 rs10853547 chr18:44530548 A/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 9.1 0.34 1.1e-18 Personality dimensions; BRCA cis rs4076764 1.000 rs7525643 chr1:163426283 G/A cg24596788 chr1:163392923 NA -0.36 -9.42 -0.35 8.15e-20 Motion sickness; BRCA cis rs6484504 0.576 rs176373 chr11:31136026 G/T cg06552810 chr11:31128660 NA -0.38 -8.34 -0.31 4.65e-16 Red blood cell count; BRCA cis rs10911232 0.507 rs3934697 chr1:183027512 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.25e-51 Hypertriglyceridemia; BRCA cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.88e-41 Motion sickness; BRCA cis rs3806843 1.000 rs4404730 chr5:140162610 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.7 -0.36 7.43e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs7352944 0.896 rs6067309 chr20:48610293 C/T cg17835207 chr20:48524531 SPATA2 0.46 10.53 0.38 4.88e-24 Psoriasis; BRCA cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs6831352 0.959 rs6532795 chr4:100042221 C/T cg12011299 chr4:100065546 ADH4 -0.52 -12.69 -0.45 4.47e-33 Alcohol dependence; BRCA cis rs7914558 0.966 rs10786727 chr10:104698523 G/A cg04362960 chr10:104952993 NT5C2 0.44 10.56 0.39 3.92e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2204008 0.505 rs11182550 chr12:38570061 A/T cg26384229 chr12:38710491 ALG10B 0.43 10.3 0.38 4.17e-23 Bladder cancer; BRCA cis rs6831352 0.918 rs2851251 chr4:100044111 A/G cg12011299 chr4:100065546 ADH4 0.51 11.77 0.42 4.27e-29 Alcohol dependence; BRCA cis rs12997796 0.556 rs35594332 chr2:86982651 G/A cg25203885 chr2:87302643 LOC285074 -0.6 -9.51 -0.35 3.69e-20 Schizophrenia; BRCA cis rs11098499 0.863 rs6853998 chr4:120475860 C/A cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs7246657 0.722 rs2075284 chr19:38189616 T/C cg14683738 chr19:37701593 ZNF585B -0.47 -7.85 -0.3 1.74e-14 Coronary artery calcification; BRCA cis rs6977660 0.714 rs17141945 chr7:19805056 T/A cg07541023 chr7:19748670 TWISTNB 0.57 9.72 0.36 6.52e-21 Thyroid stimulating hormone; BRCA cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg27297192 chr10:134578999 INPP5A 0.44 8.3 0.31 6.43e-16 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs9311474 1.000 rs7629072 chr3:52305633 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.26 8.19 0.31 1.45e-15 Electroencephalogram traits; BRCA cis rs9837602 1.000 rs4279135 chr3:99733096 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.1 0.4 2.74e-26 Breast cancer; BRCA cis rs9611565 0.625 rs9607819 chr22:41958862 C/G cg03806693 chr22:41940476 POLR3H -0.98 -17.55 -0.57 1.46e-56 Vitiligo; BRCA cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg11644478 chr21:40555479 PSMG1 -0.68 -15.39 -0.52 1.14e-45 Cognitive function; BRCA cis rs2066819 1.000 rs1802236 chr12:56679751 A/G cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg00166722 chr3:10149974 C3orf24 0.64 11.27 0.41 5.44e-27 Alzheimer's disease; BRCA cis rs2153535 0.505 rs1335629 chr6:8491863 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.64 0.36 1.22e-20 Motion sickness; BRCA cis rs7666738 0.822 rs9992360 chr4:98937123 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg08470875 chr2:26401718 FAM59B -0.62 -9.28 -0.34 2.57e-19 Gut microbiome composition (summer); BRCA cis rs2075371 0.863 rs12672691 chr7:133954431 C/T cg02659138 chr7:134003124 SLC35B4 0.36 10.4 0.38 1.69e-23 Mean platelet volume; BRCA cis rs10504229 0.683 rs58883273 chr8:58138275 A/G cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.22 0.31 1.1e-15 Mean platelet volume; BRCA cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg08807101 chr21:30365312 RNF160 0.77 20.38 0.63 1.67e-71 Dental caries; BRCA cis rs600231 0.706 rs4244811 chr11:65320780 G/A cg01292856 chr11:65242576 NA -0.35 -8.11 -0.31 2.66e-15 Bone mineral density; BRCA cis rs7975161 0.572 rs7132418 chr12:104603591 C/A cg25273343 chr12:104657179 TXNRD1 -0.61 -10.11 -0.37 2.09e-22 Toenail selenium levels; BRCA cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg12641515 chr19:46296257 DMWD -0.58 -12.91 -0.45 4.57e-34 Coronary artery disease; BRCA cis rs7617773 0.817 rs35456569 chr3:48250899 T/A cg11946769 chr3:48343235 NME6 0.68 14.01 0.48 4.49e-39 Coronary artery disease; BRCA cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg26597838 chr10:835615 NA 1.0 17.88 0.58 2.64e-58 Eosinophil percentage of granulocytes; BRCA cis rs1401999 1.000 rs939336 chr3:183685534 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.12 0.37 2.06e-22 Anterior chamber depth; BRCA cis rs208520 0.690 rs851464 chr6:66839802 C/T cg07460842 chr6:66804631 NA -1.02 -20.15 -0.62 2.95e-70 Exhaled nitric oxide output; BRCA cis rs7799006 0.527 rs73039284 chr7:2221583 C/G cg21782813 chr7:2030301 MAD1L1 0.34 8.62 0.32 5.1e-17 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs477895 0.838 rs1058735 chr11:64000410 C/G cg04317338 chr11:64019027 PLCB3 0.58 9.99 0.37 6.17e-22 Mean platelet volume; BRCA cis rs6461049 0.800 rs3778977 chr7:2159746 C/T cg21782813 chr7:2030301 MAD1L1 0.34 9.07 0.34 1.45e-18 Schizophrenia; BRCA cis rs6570726 0.791 rs9322029 chr6:145906683 A/G cg13319975 chr6:146136371 FBXO30 -0.36 -8.16 -0.31 1.73e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs736408 0.609 rs1029871 chr3:52797634 G/C cg10802521 chr3:52805072 NEK4 -0.31 -7.94 -0.3 8.93e-15 Bipolar disorder; BRCA cis rs644148 0.867 rs2571060 chr19:44971647 C/G cg15540054 chr19:45004280 ZNF180 -0.58 -12.13 -0.43 1.3e-30 Personality dimensions; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg05863683 chr7:1912471 MAD1L1 0.38 8.41 0.32 2.64e-16 Bipolar disorder and schizophrenia; BRCA cis rs1008375 0.932 rs4698629 chr4:17608884 C/G cg02297831 chr4:17616191 MED28 0.38 8.88 0.33 6.63e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.08 -0.3 3.15e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2637030 0.559 rs7728496 chr5:52867330 G/T cg06476337 chr5:52856530 NDUFS4 -0.36 -8.19 -0.31 1.44e-15 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA trans rs11098499 0.954 rs11098526 chr4:120390359 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.17 0.31 1.71e-15 Corneal astigmatism; BRCA cis rs4481887 1.000 rs4916125 chr1:248466583 A/T cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.79e-18 Common traits (Other); BRCA cis rs9469578 0.892 rs73743333 chr6:33714042 G/A cg18708504 chr6:33715942 IP6K3 0.7 10.23 0.38 7.52e-23 Phosphorus levels; BRCA cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.64e-24 Motion sickness; BRCA cis rs425277 0.606 rs2459984 chr1:2086312 A/G cg19257562 chr1:2043853 PRKCZ -0.31 -8.55 -0.32 8.97e-17 Height; BRCA cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg18305652 chr10:134549665 INPP5A 0.49 11.96 0.43 6.91e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3806843 0.966 rs2240693 chr5:140183325 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.43 -9.72 -0.36 6.14e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs6088580 0.634 rs3746455 chr20:32957216 G/A cg24642439 chr20:33292090 TP53INP2 -0.54 -11.69 -0.42 9.93e-29 Glomerular filtration rate (creatinine); BRCA cis rs514406 0.548 rs6670871 chr1:53212082 A/C cg08859206 chr1:53392774 SCP2 0.44 8.86 0.33 7.74e-18 Monocyte count; BRCA cis rs9733 0.715 rs12402006 chr1:150869829 G/A cg13175981 chr1:150552382 MCL1 0.36 8.25 0.31 9.28e-16 Tonsillectomy; BRCA cis rs1109501 0.959 rs10021214 chr4:71326670 T/C cg22786090 chr4:71381880 NA 0.36 7.86 0.3 1.67e-14 Alcoholism (heaviness of drinking); BRCA cis rs7726839 0.540 rs4957080 chr5:644552 A/C cg09021430 chr5:549028 NA 0.65 14.6 0.5 7.09e-42 Obesity-related traits; BRCA cis rs7833986 0.501 rs2719261 chr8:56941982 C/G cg23139584 chr8:56987506 RPS20;SNORD54 0.67 13.04 0.46 1.29e-34 Height; BRCA cis rs3768617 0.528 rs4652778 chr1:183097420 C/T ch.1.3577855R chr1:183094577 LAMC1 0.66 17.09 0.56 3.2e-54 Fuchs's corneal dystrophy; BRCA cis rs910316 0.737 rs175055 chr14:75488946 T/G cg11812906 chr14:75593930 NEK9 -0.63 -14.63 -0.5 4.98e-42 Height; BRCA cis rs9811920 0.638 rs10936008 chr3:99686665 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.29 -0.31 6.47e-16 Axial length; BRCA cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg12311346 chr5:56204834 C5orf35 0.56 11.38 0.41 1.86e-27 Initial pursuit acceleration; BRCA trans rs10506458 0.915 rs12426308 chr12:63405778 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.17 -18.81 -0.6 3.73e-63 Hemostatic factors and hematological phenotypes; BRCA cis rs7618915 0.501 rs13060048 chr3:52598608 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.07 0.4 3.57e-26 Bipolar disorder; BRCA cis rs12986413 0.874 rs4806832 chr19:2184652 C/T cg09261902 chr19:2140048 AP3D1 0.4 10.48 0.38 8.38e-24 Height; BRCA cis rs9649465 0.967 rs1005568 chr7:123306470 G/A cg04330084 chr7:123175371 IQUB -0.3 -8.34 -0.31 4.66e-16 Migraine; BRCA cis rs9649213 0.593 rs13232181 chr7:97935671 C/G cg24562669 chr7:97807699 LMTK2 0.44 11.75 0.42 5.32e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg06697600 chr4:7070879 GRPEL1 -0.53 -10.66 -0.39 1.58e-24 Monocyte percentage of white cells; BRCA cis rs4975709 0.610 rs1531994 chr5:1859297 T/C cg11168104 chr5:1857477 NA -0.34 -8.74 -0.33 2.07e-17 Cardiovascular disease risk factors; BRCA cis rs2842992 0.789 rs2146163 chr6:160224346 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.61 12.66 0.45 6.38e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs12479064 0.724 rs2305352 chr2:100015124 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.54 -11.23 -0.41 7.63e-27 Chronic sinus infection; BRCA cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg22906224 chr7:99728672 NA 0.44 8.26 0.31 8.37e-16 Coronary artery disease; BRCA trans rs2832077 0.824 rs4816333 chr21:30201777 C/G cg14791747 chr16:20752902 THUMPD1 0.4 9.31 0.35 2.11e-19 Cognitive test performance; BRCA cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg06064525 chr11:970664 AP2A2 -0.49 -16.42 -0.54 8.48e-51 Alzheimer's disease (late onset); BRCA cis rs6088580 0.584 rs2378203 chr20:32993846 A/T cg08999081 chr20:33150536 PIGU -0.46 -12.54 -0.44 2.14e-32 Glomerular filtration rate (creatinine); BRCA cis rs5758511 0.680 rs56111723 chr22:42664883 T/A cg00645731 chr22:42541494 CYP2D7P1 0.5 9.83 0.36 2.58e-21 Birth weight; BRCA trans rs637571 0.522 rs3016868 chr11:65764383 C/T cg17712092 chr4:129076599 LARP1B 0.56 13.47 0.47 1.47e-36 Eosinophil percentage of white cells; BRCA trans rs35110281 0.807 rs9984002 chr21:45061501 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.46 0.38 9.36e-24 Mean corpuscular volume; BRCA cis rs7772486 0.875 rs2814869 chr6:146315509 G/A cg23711669 chr6:146136114 FBXO30 0.73 17.03 0.56 6.83e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs3749237 1.000 rs6804655 chr3:49738945 C/T cg07636037 chr3:49044803 WDR6 0.41 8.4 0.32 2.89e-16 Resting heart rate; BRCA cis rs9443645 0.869 rs10943585 chr6:79502409 G/C cg09184832 chr6:79620586 NA -0.5 -10.76 -0.39 6.16e-25 Intelligence (multi-trait analysis); BRCA cis rs9612 1.000 rs9612 chr19:44235517 A/G cg08581076 chr19:44259116 C19orf61 0.56 9.83 0.36 2.44e-21 Exhaled nitric oxide output; BRCA cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg24562669 chr7:97807699 LMTK2 0.44 11.75 0.42 5.51e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs3916 0.910 rs7306541 chr12:121130046 A/G cg21892295 chr12:121157589 UNC119B -0.38 -9.7 -0.36 7.38e-21 Urinary metabolites (H-NMR features); BRCA cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 10.38 0.38 1.97e-23 Bipolar disorder; BRCA cis rs2836950 0.565 rs7278297 chr21:40625752 A/C cg11890956 chr21:40555474 PSMG1 -0.6 -13.39 -0.47 3.1e-36 Menarche (age at onset); BRCA cis rs9790314 0.586 rs67077657 chr3:161138521 A/G cg04691961 chr3:161091175 C3orf57 -0.4 -9.15 -0.34 7.42e-19 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs6854594 chr4:99065312 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.64 0.39 1.87e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs7395662 0.784 rs2170661 chr11:48378186 C/T cg00717180 chr2:96193071 NA -0.29 -8.19 -0.31 1.44e-15 HDL cholesterol; BRCA cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg16405210 chr4:1374714 KIAA1530 -0.92 -20.93 -0.64 1.71e-74 Longevity; BRCA cis rs41005 0.967 rs193927 chr2:8108055 G/A cg03155496 chr2:8117019 LOC339788 0.57 15.05 0.51 4.8e-44 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs2033711 0.870 rs7408188 chr19:58939389 T/G cg11952622 chr19:58962976 ZNF324B 0.43 8.86 0.33 7.99e-18 Uric acid clearance; BRCA cis rs1865760 0.566 rs2858993 chr6:26087856 T/A cg17691542 chr6:26056736 HIST1H1C 0.56 11.7 0.42 8.36e-29 Height; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg03923535 chr7:1197113 ZFAND2A 0.5 10.86 0.39 2.55e-25 Longevity;Endometriosis; BRCA cis rs677665 0.537 rs6688233 chr1:9335745 A/G cg25755851 chr1:9335794 NA -0.83 -17.7 -0.57 2.27e-57 Eosinophil percentage of white cells; BRCA cis rs10504229 0.683 rs55807014 chr8:58131801 T/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg26314531 chr2:26401878 FAM59B -0.9 -16.15 -0.54 1.92e-49 Gut microbiome composition (summer); BRCA cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg06671706 chr8:8559999 CLDN23 0.44 8.48 0.32 1.54e-16 Obesity-related traits; BRCA cis rs67311347 1.000 rs7642552 chr3:40424816 T/C cg01475735 chr3:40494733 NA -0.4 -8.19 -0.31 1.39e-15 Renal cell carcinoma; BRCA cis rs425277 0.606 rs377283 chr1:2075570 T/C cg04315214 chr1:2043799 PRKCZ -0.48 -12.57 -0.45 1.58e-32 Height; BRCA cis rs2073300 0.609 rs17757442 chr20:23421101 A/G cg12062639 chr20:23401060 NAPB -0.92 -13.17 -0.46 3.2e-35 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs11165623 0.740 rs11165638 chr1:96921357 C/A cg10631902 chr5:14652156 NA -0.51 -16.06 -0.54 5.42e-49 Hip circumference;Waist circumference; BRCA cis rs9291683 0.655 rs55941493 chr4:10100341 G/A cg00071950 chr4:10020882 SLC2A9 -0.48 -11.7 -0.42 8.81e-29 Bone mineral density; BRCA cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.52 -0.44 2.53e-32 Developmental language disorder (linguistic errors); BRCA cis rs6752107 1.000 rs10165561 chr2:234172915 G/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.54 0.42 4.13e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs62103177 0.525 rs62101233 chr18:77724288 C/T cg02751453 chr18:77725136 HSBP1L1 -0.48 -11.03 -0.4 5.19e-26 Opioid sensitivity; BRCA cis rs10504229 1.000 rs66672857 chr8:58179817 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9815354 0.812 rs7639859 chr3:42001987 C/T cg03022575 chr3:42003672 ULK4 0.62 9.12 0.34 9.65e-19 Pulse pressure;Diastolic blood pressure; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.46 -0.32 1.85e-16 Total body bone mineral density; BRCA cis rs910316 1.000 rs175443 chr14:75601963 C/T cg08847533 chr14:75593920 NEK9 -0.85 -21.6 -0.65 4.13e-78 Height; BRCA cis rs826838 1.000 rs7315028 chr12:38710523 G/A cg26384229 chr12:38710491 ALG10B 0.87 23.88 0.69 1.49e-90 Heart rate; BRCA cis rs6840360 0.615 rs12647462 chr4:152607278 C/T cg22705602 chr4:152727874 NA -0.38 -10.37 -0.38 2.15e-23 Intelligence (multi-trait analysis); BRCA cis rs73001065 0.711 rs58489806 chr19:19456917 C/T cg03709012 chr19:19516395 GATAD2A 0.89 11.98 0.43 5.63e-30 LDL cholesterol; BRCA cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.75 -0.33 1.84e-17 Aortic root size; BRCA cis rs1003719 0.788 rs2835574 chr21:38455324 C/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.18 0.49 7.08e-40 Eye color traits; BRCA cis rs72634258 0.554 rs4908699 chr1:7905274 G/A cg26816564 chr1:7831052 VAMP3 0.7 12.86 0.45 7.69e-34 Inflammatory bowel disease; BRCA cis rs12142240 0.698 rs10158572 chr1:46822440 G/T cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs12477438 0.798 rs6732579 chr2:99560239 A/T cg08885076 chr2:99613938 TSGA10 -0.59 -13.2 -0.46 2.29e-35 Chronic sinus infection; BRCA cis rs13191362 0.507 rs2849518 chr6:163134248 T/C cg06582575 chr6:163149167 PACRG;PARK2 -0.49 -9.35 -0.35 1.44e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.26e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6120849 0.707 rs6088703 chr20:33676049 T/A cg24642439 chr20:33292090 TP53INP2 0.57 9.73 0.36 6.02e-21 Protein C levels; BRCA cis rs861020 1.000 rs642961 chr1:209989270 A/G cg09163369 chr1:210001066 C1orf107 0.55 10.61 0.39 2.4e-24 Orofacial clefts; BRCA cis rs10504229 0.595 rs76447299 chr8:58117395 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs453301 0.653 rs7016139 chr8:8895470 A/G cg15556689 chr8:8085844 FLJ10661 -0.43 -11.66 -0.42 1.28e-28 Joint mobility (Beighton score); BRCA cis rs4363385 0.818 rs10888524 chr1:153000125 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.38 -0.31 3.34e-16 Inflammatory skin disease; BRCA cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg22496339 chr2:162101262 NA 0.58 13.12 0.46 5.49e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs2153535 0.580 rs9406159 chr6:8464859 C/G cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs6089829 0.925 rs6122087 chr20:61664553 T/C cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs72781680 0.611 rs72783625 chr2:24315540 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.16 0.31 1.77e-15 Lymphocyte counts; BRCA cis rs11190604 0.945 rs11190553 chr10:102207959 T/C cg07080220 chr10:102295463 HIF1AN 0.49 11.15 0.4 1.7e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg22920501 chr2:26401640 FAM59B 0.9 14.59 0.5 7.9e-42 Gut microbiome composition (summer); BRCA cis rs801193 0.591 rs721717 chr7:66130292 G/T cg18876405 chr7:65276391 NA -0.49 -10.77 -0.39 5.56e-25 Aortic root size; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA trans rs1945213 0.694 rs1384099 chr11:55866040 A/C cg03929089 chr4:120376271 NA 0.57 9.82 0.36 2.63e-21 Acute lymphoblastic leukemia (childhood); BRCA cis rs858239 0.899 rs2268745 chr7:23317600 G/A cg23682824 chr7:23144976 KLHL7 0.34 8.49 0.32 1.45e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs6461049 0.765 rs10224497 chr7:2149967 A/G cg00106254 chr7:1943704 MAD1L1 -0.32 -8.53 -0.32 1.07e-16 Schizophrenia; BRCA cis rs6981523 0.553 rs11783045 chr8:11056175 A/G cg21775007 chr8:11205619 TDH -0.48 -9.6 -0.36 1.78e-20 Neuroticism; BRCA cis rs9796 0.621 rs690733 chr15:41476465 G/A cg18705301 chr15:41695430 NDUFAF1 -0.37 -8.01 -0.3 5.56e-15 Menopause (age at onset); BRCA cis rs8180040 0.934 rs4858811 chr3:47480524 G/C cg16586182 chr3:47516702 SCAP 0.66 15.18 0.51 1.16e-44 Colorectal cancer; BRCA cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.56 0.35 2.51e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs992157 0.835 rs2292550 chr2:219140288 G/C cg00012203 chr2:219082015 ARPC2 -0.51 -9.79 -0.36 3.66e-21 Colorectal cancer; BRCA cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.64 0.45 7.93e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs6951245 1.000 rs77305932 chr7:1100861 T/A cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.99 0.53 1.18e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg04025307 chr7:1156635 C7orf50 0.57 10.98 0.4 7.82e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6942756 1.000 rs2103232 chr7:128951232 G/T cg02491457 chr7:128862824 NA -0.71 -13.98 -0.48 6.22e-39 White matter hyperintensity burden; BRCA cis rs3806843 1.000 rs3756340 chr5:140180451 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.83 -0.36 2.54e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs67478160 0.643 rs8004408 chr14:104203938 G/A cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.33 -0.41 3.17e-27 Schizophrenia; BRCA cis rs16976116 0.901 rs1061823 chr15:55496043 T/A cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.49e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3858526 0.665 rs10839170 chr11:6003512 C/T cg13902645 chr11:5959945 NA -0.41 -8.83 -0.33 1.02e-17 DNA methylation (variation); BRCA cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg05025164 chr4:1340916 KIAA1530 -0.76 -14.92 -0.51 2.16e-43 Longevity; BRCA cis rs919433 0.617 rs700646 chr2:198608511 C/T cg00792783 chr2:198669748 PLCL1 0.46 10.07 0.37 3.04e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs910316 0.789 rs175444 chr14:75601782 G/C cg11812906 chr14:75593930 NEK9 -0.61 -13.79 -0.48 4.55e-38 Height; BRCA cis rs7647973 0.626 rs1352889 chr3:49652148 T/C cg07636037 chr3:49044803 WDR6 0.51 8.57 0.32 7.96e-17 Menarche (age at onset); BRCA cis rs6964587 1.000 rs6968870 chr7:91661111 G/C cg17063962 chr7:91808500 NA 0.54 12.61 0.45 1.07e-32 Breast cancer; BRCA cis rs4305276 0.557 rs7607996 chr2:241470735 T/C cg03743720 chr2:241460002 ANKMY1 0.21 8.56 0.32 8.61e-17 Mean platelet volume; BRCA cis rs12142240 0.698 rs17361887 chr1:46834775 A/G cg14993813 chr1:46806288 NSUN4 -0.46 -8.86 -0.33 7.98e-18 Menopause (age at onset); BRCA trans rs78049276 0.736 rs10305838 chr4:148400256 T/C cg13149281 chr14:23389818 RBM23;PRMT5 -0.43 -8.01 -0.3 5.59e-15 Pulse pressure; BRCA cis rs12549902 1.000 rs12549902 chr8:41509259 C/T cg21772509 chr8:41503840 NKX6-3 0.48 11.28 0.41 4.91e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs3785574 0.962 rs9944483 chr17:61783553 G/T cg01411255 chr17:61851458 DDX42;CCDC47 -0.82 -22.31 -0.66 5.68e-82 Height; BRCA cis rs6582630 0.555 rs11610015 chr12:38508856 A/G cg26384229 chr12:38710491 ALG10B 0.67 16.04 0.54 6.77e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs919433 0.963 rs4850787 chr2:198181750 G/A cg10820045 chr2:198174542 NA -0.38 -8.38 -0.31 3.32e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg25208724 chr1:156163844 SLC25A44 0.9 26.45 0.72 1.1e-104 Testicular germ cell tumor; BRCA cis rs7772486 0.754 rs1415746 chr6:146077107 A/G cg05347473 chr6:146136440 FBXO30 -0.44 -8.89 -0.33 6.26e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs6542838 0.641 rs6741166 chr2:99534926 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.41 -9.2 -0.34 5.11e-19 Fear of minor pain; BRCA trans rs2018683 0.677 rs2057956 chr7:28973460 G/A cg19402173 chr7:128379420 CALU -0.42 -9.88 -0.36 1.64e-21 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs6121246 0.559 rs6060950 chr20:30378031 T/C cg21427119 chr20:30132790 HM13 -0.36 -8.14 -0.31 2.08e-15 Mean corpuscular hemoglobin; BRCA cis rs561341 1.000 rs564714 chr17:30318404 C/T cg00745463 chr17:30367425 LRRC37B -0.61 -9.81 -0.36 2.98e-21 Hip circumference adjusted for BMI; BRCA cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.2 0.41 1.02e-26 Bipolar disorder; BRCA cis rs7833986 1.000 rs36103212 chr8:57101475 G/T cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.22 0.31 1.17e-15 Height; BRCA cis rs7215564 0.818 rs901063 chr17:78595696 A/T cg06153925 chr17:78755379 RPTOR -0.48 -8.2 -0.31 1.31e-15 Myopia (pathological); BRCA trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.62 0.36 1.5e-20 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.07 0.62 7.34e-70 Platelet count; BRCA cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg06552810 chr11:31128660 NA -0.38 -8.41 -0.32 2.64e-16 Red blood cell count; BRCA trans rs637571 0.528 rs11602769 chr11:65594139 T/C cg17712092 chr4:129076599 LARP1B -0.54 -12.3 -0.44 2.28e-31 Eosinophil percentage of white cells; BRCA trans rs10506458 0.915 rs998505 chr12:63400018 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.23 -19.5 -0.61 8.19e-67 Hemostatic factors and hematological phenotypes; BRCA cis rs3733585 0.783 rs13148371 chr4:10032561 C/T cg11266682 chr4:10021025 SLC2A9 0.49 12.91 0.45 4.62e-34 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13102973 0.614 rs56199725 chr4:135873448 T/C cg14419869 chr4:135874104 NA -0.52 -11.05 -0.4 4.13e-26 Subjective well-being; BRCA cis rs10751667 0.666 rs7936830 chr11:959686 A/G cg10932868 chr11:921992 NA 0.49 12.51 0.44 2.84e-32 Alzheimer's disease (late onset); BRCA cis rs12142240 0.698 rs6697123 chr1:46811310 A/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA trans rs3857536 0.776 rs4710583 chr6:66940101 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.41 0.35 8.9e-20 Tonsillectomy; BRCA cis rs35110281 0.720 rs162400 chr21:44950305 A/C cg04455712 chr21:45112962 RRP1B 0.41 10.44 0.38 1.19e-23 Mean corpuscular volume; BRCA cis rs312274 0.515 rs2772458 chr12:41252465 G/A cg17827154 chr12:41323612 CNTN1 -0.42 -10.07 -0.37 2.96e-22 Metabolite levels (X-11787); BRCA trans rs1493916 0.748 rs2040203 chr18:31307420 G/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.37 -0.31 3.71e-16 Life satisfaction; BRCA cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.07 0.3 3.55e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3008870 1.000 rs4620509 chr1:67449941 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.6 -0.67 1.57e-83 Lymphocyte percentage of white cells; BRCA cis rs425277 0.606 rs262663 chr1:2084598 T/C cg19257562 chr1:2043853 PRKCZ -0.34 -9.65 -0.36 1.21e-20 Height; BRCA cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.18 -0.31 1.55e-15 Menarche (age at onset); BRCA cis rs6964587 0.967 rs10953063 chr7:91576958 A/G cg17063962 chr7:91808500 NA -0.53 -12.33 -0.44 1.78e-31 Breast cancer; BRCA cis rs7085104 0.684 rs7092690 chr10:104609365 T/C cg04362960 chr10:104952993 NT5C2 0.4 9.57 0.35 2.3e-20 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.75 0.36 5.03e-21 Bipolar disorder; BRCA cis rs2652822 1.000 rs2652822 chr15:63422772 C/T cg02713581 chr15:63449717 RPS27L -0.41 -8.45 -0.32 1.95e-16 Metabolic traits; BRCA cis rs10504229 1.000 rs67344620 chr8:58187537 C/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg15145296 chr3:125709740 NA -0.55 -8.69 -0.33 3.04e-17 Blood pressure (smoking interaction); BRCA cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg15017067 chr4:17643749 FAM184B 0.28 8.27 0.31 7.51e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.6 -0.32 6.18e-17 Total body bone mineral density; BRCA cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs7100689 0.646 rs1340384 chr10:82088702 T/A cg01528321 chr10:82214614 TSPAN14 0.81 17.21 0.56 8.09e-55 Post bronchodilator FEV1; BRCA cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -15.24 -0.52 5.84e-45 Systemic lupus erythematosus; BRCA trans rs3749237 1.000 rs4768 chr3:49758764 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.36 9.14 0.34 7.95e-19 Resting heart rate; BRCA cis rs8032158 1.000 rs28660477 chr15:56145267 T/C cg02198044 chr15:56286336 NEDD4 -0.38 -9.04 -0.34 1.8e-18 Keloid; BRCA cis rs1881797 1.000 rs12063141 chr1:247688343 G/A cg05639522 chr1:247681581 NA 0.53 11.63 0.42 1.75e-28 Acute lymphoblastic leukemia (childhood); BRCA cis rs113835537 0.529 rs3741360 chr11:66300348 A/G cg24851651 chr11:66362959 CCS 0.46 8.56 0.32 8.11e-17 Airway imaging phenotypes; BRCA cis rs2033711 0.870 rs7259841 chr19:58951123 T/C cg00825309 chr19:58991885 ZNF446 -0.59 -12.89 -0.45 5.93e-34 Uric acid clearance; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg23978390 chr7:1156363 C7orf50 0.4 9.33 0.35 1.69e-19 Longevity;Endometriosis; BRCA cis rs7927771 0.524 rs10742817 chr11:47689343 A/G cg20307385 chr11:47447363 PSMC3 -0.45 -10.5 -0.38 6.56e-24 Subjective well-being; BRCA cis rs2576037 0.583 rs9960463 chr18:44522808 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 13.66 0.48 1.8e-37 Personality dimensions; BRCA cis rs16958440 0.867 rs12326457 chr18:44678425 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs11955398 0.585 rs10063407 chr5:60009063 C/T cg02684056 chr5:59996105 DEPDC1B -0.37 -9.1 -0.34 1.1e-18 Intelligence (multi-trait analysis); BRCA cis rs7264396 0.635 rs6058344 chr20:34475038 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.83 -0.51 5.74e-43 Total cholesterol levels; BRCA cis rs12210905 0.688 rs72843151 chr6:27359268 A/C cg08851530 chr6:28072375 NA 0.84 8.3 0.31 6.28e-16 Hip circumference adjusted for BMI; BRCA trans rs877282 0.945 rs10904554 chr10:786768 T/C cg22713356 chr15:30763199 NA 1.35 27.01 0.73 9.19e-108 Uric acid levels; BRCA cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg26597838 chr10:835615 NA 1.02 17.81 0.58 6.47e-58 Eosinophil percentage of granulocytes; BRCA cis rs17376456 0.877 rs28418572 chr5:93144161 A/C cg25358565 chr5:93447407 FAM172A 1.17 18.25 0.59 3.42e-60 Diabetic retinopathy; BRCA cis rs7178572 0.568 rs3743479 chr15:77406396 A/G cg22256960 chr15:77711686 NA 0.38 8.21 0.31 1.27e-15 Type 2 diabetes; BRCA cis rs67478160 0.654 rs4906365 chr14:104229230 G/C cg08213375 chr14:104286397 PPP1R13B 0.6 16.35 0.54 1.85e-50 Schizophrenia; BRCA cis rs7246657 0.722 rs2927746 chr19:38156570 G/A cg18154014 chr19:37997991 ZNF793 -0.49 -9.15 -0.34 7.83e-19 Coronary artery calcification; BRCA cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.43e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.62 13.15 0.46 3.9e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6598955 0.671 rs12139514 chr1:26575939 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.74e-16 Obesity-related traits; BRCA cis rs12347191 0.500 rs907580 chr9:100622597 T/C cg13688889 chr9:100608707 NA -0.48 -9.76 -0.36 4.62e-21 Orofacial clefts; BRCA cis rs1499614 0.901 rs3936 chr7:66126489 C/T cg18252515 chr7:66147081 NA -1.07 -15.86 -0.53 4.97e-48 Gout; BRCA cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg18876405 chr7:65276391 NA -0.49 -11.0 -0.4 6.88e-26 Aortic root size; BRCA cis rs12701220 0.655 rs10241018 chr7:1144774 G/C cg00990874 chr7:1149470 C7orf50 -0.63 -13.23 -0.46 1.71e-35 Bronchopulmonary dysplasia; BRCA cis rs12367572 1.000 rs7295923 chr12:45269284 C/T cg04608330 chr12:45269318 NELL2 -0.64 -14.31 -0.49 1.77e-40 Gut microbiome composition (summer); BRCA trans rs1945213 0.625 rs7128190 chr11:55858550 A/T cg15704280 chr7:45808275 SEPT13 0.65 11.44 0.41 1.06e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs61990749 0.597 rs6574402 chr14:78267950 C/A cg02301378 chr14:78227641 SNW1;C14orf178 0.65 9.9 0.36 1.33e-21 Fibroblast growth factor basic levels; BRCA cis rs9467773 0.804 rs2073526 chr6:26374658 C/T cg09904177 chr6:26538194 HMGN4 -0.37 -9.86 -0.36 1.86e-21 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.669 rs7634084 chr3:49949834 A/T cg24110177 chr3:50126178 RBM5 -0.4 -11.04 -0.4 4.86e-26 Intelligence (multi-trait analysis); BRCA cis rs7584330 0.518 rs7585969 chr2:238439073 G/A cg08992911 chr2:238395768 MLPH 0.49 8.16 0.31 1.82e-15 Prostate cancer; BRCA trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.96 -0.56 1.56e-53 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg05283184 chr6:79620031 NA -0.41 -10.62 -0.39 2.34e-24 Intelligence (multi-trait analysis); BRCA cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg20503657 chr10:835505 NA 0.98 14.97 0.51 1.18e-43 Eosinophil percentage of granulocytes; BRCA cis rs801193 1.000 rs1553609 chr7:66197139 T/C cg18876405 chr7:65276391 NA 0.62 15.36 0.52 1.43e-45 Aortic root size; BRCA trans rs1005277 0.502 rs2800484 chr10:38542415 C/T cg23533926 chr12:111358616 MYL2 -0.44 -9.21 -0.34 4.48e-19 Extrinsic epigenetic age acceleration; BRCA cis rs9291683 0.588 rs11732054 chr4:9999877 C/T cg11266682 chr4:10021025 SLC2A9 0.46 12.01 0.43 4.29e-30 Bone mineral density; BRCA cis rs10197940 0.578 rs2432957 chr2:152287897 A/C cg06191203 chr2:152266755 RIF1 -0.27 -8.04 -0.3 4.25e-15 Lung cancer; BRCA cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg27170947 chr2:26402098 FAM59B -0.94 -16.9 -0.56 3.15e-53 Gut microbiome composition (summer); BRCA cis rs2204008 0.668 rs1619009 chr12:38120485 G/A cg26384229 chr12:38710491 ALG10B -0.46 -10.56 -0.39 3.78e-24 Bladder cancer; BRCA cis rs796364 1.000 rs281783 chr2:200751582 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.67 0.42 1.12e-28 Schizophrenia; BRCA trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg11887960 chr12:57824829 NA 0.55 8.57 0.32 7.74e-17 Lung disease severity in cystic fibrosis; BRCA cis rs17384381 1.000 rs12133722 chr1:85873237 C/T cg16011679 chr1:85725395 C1orf52 0.52 8.06 0.3 3.87e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg11833968 chr6:79620685 NA -0.42 -9.37 -0.35 1.24e-19 Intelligence (multi-trait analysis); BRCA cis rs875971 0.545 rs1796226 chr7:66087710 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.49 9.4 0.35 9.41e-20 Aortic root size; BRCA cis rs2414095 0.520 rs3784307 chr15:51506634 G/A cg19946085 chr15:51559439 CYP19A1 -0.31 -8.66 -0.32 3.98e-17 Follicule stimulating hormone;Hormone measurements;Total body bone mineral density; BRCA cis rs887829 0.508 rs1104892 chr2:234620272 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.34 -8.49 -0.32 1.5e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs798554 0.634 rs6970963 chr7:2821271 C/T cg18446336 chr7:2847575 GNA12 -0.35 -8.3 -0.31 6.43e-16 Height; BRCA cis rs561341 0.883 rs1034627 chr17:30219569 C/T cg13647721 chr17:30228624 UTP6 0.56 10.06 0.37 3.31e-22 Hip circumference adjusted for BMI; BRCA cis rs1008375 0.931 rs2315558 chr4:17674558 C/A cg04450456 chr4:17643702 FAM184B 0.39 11.78 0.42 3.97e-29 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3862030 0.810 rs5870 chr10:104239100 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -12.98 -0.46 2.36e-34 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs4730250 0.802 rs77936580 chr7:106946343 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.6 -0.32 6.14e-17 Osteoarthritis; BRCA cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg13395646 chr4:1353034 KIAA1530 -0.51 -9.41 -0.35 9e-20 Obesity-related traits; BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg04518342 chr5:131593106 PDLIM4 0.4 9.13 0.34 9e-19 Acylcarnitine levels; BRCA cis rs10267417 0.557 rs10249101 chr7:19895397 T/G cg07541023 chr7:19748670 TWISTNB 0.46 8.4 0.32 2.86e-16 Night sleep phenotypes; BRCA cis rs6748734 1.000 rs4293565 chr2:241834770 A/G cg07537917 chr2:241836409 C2orf54 -0.45 -10.18 -0.37 1.16e-22 Urinary metabolites; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.21 -0.31 1.19e-15 Gut microbiome composition (summer); BRCA cis rs514406 0.505 rs6688064 chr1:53165609 C/T cg08859206 chr1:53392774 SCP2 -0.41 -8.23 -0.31 1.02e-15 Monocyte count; BRCA cis rs798554 0.797 rs1182184 chr7:2872446 G/A cg21143896 chr7:2802374 GNA12 -0.35 -8.88 -0.33 6.7e-18 Height; BRCA cis rs9487051 0.597 rs9400265 chr6:109594932 A/C cg01475377 chr6:109611718 NA -0.41 -8.17 -0.31 1.69e-15 Reticulocyte fraction of red cells; BRCA cis rs6121246 0.559 rs6087771 chr20:30306724 A/G cg21427119 chr20:30132790 HM13 -0.35 -7.89 -0.3 1.33e-14 Mean corpuscular hemoglobin; BRCA cis rs11098499 0.722 rs17595727 chr4:120262074 C/T cg09307838 chr4:120376055 NA -0.59 -12.91 -0.45 4.74e-34 Corneal astigmatism; BRCA cis rs1707322 1.000 rs10890378 chr1:46410657 A/G cg06784218 chr1:46089804 CCDC17 -0.46 -10.92 -0.4 1.4e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9420 0.922 rs35808061 chr11:57547000 T/C cg19752551 chr11:57585705 CTNND1 -0.51 -12.56 -0.45 1.65e-32 Schizophrenia; BRCA cis rs701145 0.556 rs355751 chr3:153971602 T/C cg12800244 chr3:153838788 SGEF 0.43 8.37 0.31 3.6e-16 Coronary artery disease; BRCA cis rs7044106 0.762 rs7044226 chr9:123466328 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.62 13.07 0.46 9.51e-35 Hip circumference adjusted for BMI; BRCA cis rs7945705 0.692 rs2742470 chr11:9004002 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.44 -0.5 4.19e-41 Hemoglobin concentration; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg20224285 chr3:52813920 ITIH1 0.32 8.16 0.31 1.78e-15 Bipolar disorder; BRCA cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg19628046 chr18:33552617 C18orf21 0.54 10.88 0.4 2e-25 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs12310956 0.532 rs7979535 chr12:33947450 A/C cg26384229 chr12:38710491 ALG10B -0.66 -13.87 -0.48 2e-38 Morning vs. evening chronotype; BRCA cis rs7945718 0.967 rs10741602 chr11:12761699 A/T cg25843174 chr11:12811716 TEAD1 0.23 8.73 0.33 2.22e-17 Educational attainment (years of education); BRCA cis rs68170813 0.523 rs79607134 chr7:107033619 A/T cg02696742 chr7:106810147 HBP1 -0.51 -8.45 -0.32 1.93e-16 Coronary artery disease; BRCA cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs6951245 0.935 rs78573577 chr7:1089087 C/A cg13565492 chr6:43139072 SRF -0.79 -10.84 -0.39 2.99e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg11266682 chr4:10021025 SLC2A9 0.39 10.35 0.38 2.47e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7811142 0.887 rs4074838 chr7:100032665 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 21.34 0.65 1.06e-76 Platelet count; BRCA cis rs13315871 0.929 rs76226186 chr3:58318499 C/T cg20936604 chr3:58311152 NA -0.66 -8.48 -0.32 1.5e-16 Cholesterol, total; BRCA cis rs17376456 0.741 rs12374432 chr5:93481348 C/A cg21475434 chr5:93447410 FAM172A 0.68 8.96 0.33 3.44e-18 Diabetic retinopathy; BRCA cis rs7903847 0.642 rs7078782 chr10:99168604 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.76 -0.33 1.77e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs1008375 1.000 rs6449323 chr4:17683916 A/T cg16339924 chr4:17578868 LAP3 0.55 13.27 0.46 1.13e-35 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg16423285 chr20:60520624 NA 0.43 8.09 0.3 3.09e-15 Body mass index; BRCA cis rs10197940 0.662 rs4467261 chr2:152281391 G/C cg06191203 chr2:152266755 RIF1 -0.31 -9.12 -0.34 9.48e-19 Lung cancer; BRCA cis rs11098499 0.874 rs6851169 chr4:120117510 T/C cg09307838 chr4:120376055 NA 0.6 11.15 0.4 1.65e-26 Corneal astigmatism; BRCA cis rs735396 1.000 rs2259852 chr12:121434833 G/A cg02403541 chr12:121454288 C12orf43 0.54 10.3 0.38 3.9699999999999997e-23 N-glycan levels; BRCA cis rs2882667 0.861 rs11242445 chr5:138417054 G/T cg04439458 chr5:138467593 SIL1 -0.37 -10.37 -0.38 2.13e-23 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7572733 0.514 rs700686 chr2:198721054 G/A cg00792783 chr2:198669748 PLCL1 0.47 10.12 0.37 1.95e-22 Dermatomyositis; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg26224354 chr7:1096374 C7orf50;GPR146 -0.39 -8.36 -0.31 3.78e-16 Longevity;Endometriosis; BRCA cis rs9811920 0.809 rs4577503 chr3:99657922 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -13.62 -0.47 2.71e-37 Axial length; BRCA cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg05283184 chr6:79620031 NA -0.43 -11.1 -0.4 2.77e-26 Intelligence (multi-trait analysis); BRCA cis rs2011503 0.509 rs76347963 chr19:19780145 C/T cg11584989 chr19:19387371 SF4 0.4 7.98 0.3 6.96e-15 Bipolar disorder; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.03 -0.3 4.73e-15 Total body bone mineral density; BRCA cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg21535247 chr6:8435926 SLC35B3 0.41 9.38 0.35 1.09e-19 Motion sickness; BRCA cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg02891314 chr5:179741120 GFPT2 -0.69 -14.06 -0.49 2.67e-39 Height; BRCA cis rs7833790 0.660 rs10091077 chr8:82705464 A/G cg17211192 chr8:82754475 SNX16 -0.53 -11.22 -0.41 8.52e-27 Diastolic blood pressure; BRCA cis rs6912958 0.559 rs242281 chr6:88048916 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.57 12.13 0.43 1.3e-30 Monocyte percentage of white cells; BRCA cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11890956 chr21:40555474 PSMG1 0.98 23.59 0.68 5.27e-89 Cognitive function; BRCA cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs72781680 1.000 rs963725 chr2:24148231 T/C cg08917208 chr2:24149416 ATAD2B 1.12 15.97 0.53 1.45e-48 Lymphocyte counts; BRCA cis rs6089584 0.606 rs2144674 chr20:60576579 G/A cg06108461 chr20:60628389 TAF4 -0.64 -13.43 -0.47 2.18e-36 Body mass index; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg12419862 chr22:24373484 LOC391322 0.7 15.81 0.53 9.36e-48 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg26119090 chr2:26468346 HADHA;HADHB -0.76 -13.42 -0.47 2.38e-36 Gut microbiome composition (summer); BRCA trans rs1005277 0.579 rs2504148 chr10:38400788 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.51 -0.32 1.2e-16 Extrinsic epigenetic age acceleration; BRCA cis rs7824557 0.724 rs2572398 chr8:11178093 A/C cg21775007 chr8:11205619 TDH 0.62 13.54 0.47 6.95e-37 Retinal vascular caliber; BRCA cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg05872129 chr22:39784769 NA 0.56 11.67 0.42 1.16e-28 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg24006582 chr15:45444508 DUOX1 0.55 10.71 0.39 9.9e-25 Uric acid levels; BRCA trans rs61931739 0.857 rs999715 chr12:34143253 G/C cg26384229 chr12:38710491 ALG10B 0.43 10.46 0.38 9.72e-24 Morning vs. evening chronotype; BRCA cis rs701145 0.617 rs7426835 chr3:154049539 C/T cg16511985 chr3:153974050 SGEF 0.41 8.85 0.33 8.5e-18 Coronary artery disease; BRCA cis rs10504229 1.000 rs76023408 chr8:58193345 A/G cg14926445 chr8:58193284 C8orf71 -0.47 -9.08 -0.34 1.37e-18 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg11890956 chr21:40555474 PSMG1 0.59 13.25 0.46 1.38e-35 Menarche (age at onset); BRCA cis rs2288912 0.838 rs7251503 chr19:45455715 C/G cg10169327 chr19:45448959 APOC2 0.31 7.81 0.3 2.28e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs769267 0.598 rs8108705 chr19:19675367 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.42 -8.06 -0.3 3.9e-15 Tonsillectomy; BRCA cis rs9467773 0.620 rs2494700 chr6:26631306 C/T cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg24562669 chr7:97807699 LMTK2 0.45 11.98 0.43 5.55e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs6860806 0.531 rs274556 chr5:131722075 A/G cg24060327 chr5:131705240 SLC22A5 0.62 11.66 0.42 1.24e-28 Breast cancer; BRCA trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg23533926 chr12:111358616 MYL2 -0.44 -8.94 -0.33 4.28e-18 Extrinsic epigenetic age acceleration; BRCA trans rs8002861 0.840 rs1819597 chr13:44429553 G/A cg17145862 chr1:211918768 LPGAT1 0.63 16.04 0.54 6.57e-49 Leprosy; BRCA trans rs61931739 0.517 rs11053063 chr12:34181011 C/T cg26384229 chr12:38710491 ALG10B 0.68 14.54 0.5 1.35e-41 Morning vs. evening chronotype; BRCA cis rs9467711 0.591 rs67296946 chr6:26048559 T/G cg08501292 chr6:25962987 TRIM38 0.57 8.04 0.3 4.27e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs12477438 0.765 rs7607578 chr2:99669771 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs9393692 0.875 rs12526215 chr6:26262916 T/C cg13736514 chr6:26305472 NA -0.36 -11.99 -0.43 5.24e-30 Educational attainment; BRCA trans rs2832077 0.527 rs11088095 chr21:30223188 A/T cg14791747 chr16:20752902 THUMPD1 0.45 14.26 0.49 3.08e-40 Cognitive test performance; BRCA cis rs7267979 0.899 rs442834 chr20:25458096 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.32 8.84 0.33 9.09e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9837602 0.551 rs1630555 chr3:99423273 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -8.7 -0.33 2.86e-17 Breast cancer; BRCA cis rs763121 0.776 rs4820346 chr22:39125074 C/G cg06022373 chr22:39101656 GTPBP1 -0.68 -16.54 -0.55 2.13e-51 Menopause (age at onset); BRCA cis rs7264396 0.779 rs6087723 chr20:34175783 G/A cg04508476 chr20:34239394 CPNE1;RBM12 0.54 11.17 0.4 1.44e-26 Total cholesterol levels; BRCA cis rs6912958 0.559 rs373646 chr6:88056896 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.57 12.24 0.44 4.35e-31 Monocyte percentage of white cells; BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg03354898 chr7:1950403 MAD1L1 -0.46 -9.19 -0.34 5.64e-19 Bipolar disorder and schizophrenia; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs11098499 0.909 rs79026312 chr4:120440677 C/A cg09307838 chr4:120376055 NA 0.69 14.05 0.49 2.92e-39 Corneal astigmatism; BRCA cis rs6964587 0.934 rs1544377 chr7:91687351 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs7208859 0.623 rs11650271 chr17:29213943 C/T cg13385521 chr17:29058706 SUZ12P 0.63 8.58 0.32 7.12e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 3.77e-39 Extrinsic epigenetic age acceleration; BRCA cis rs600231 0.708 rs602838 chr11:65253247 T/G cg01292856 chr11:65242576 NA 0.35 8.74 0.33 2.08e-17 Bone mineral density; BRCA cis rs6088580 0.608 rs8114616 chr20:32969092 G/T cg06115741 chr20:33292138 TP53INP2 -0.38 -8.33 -0.31 4.82e-16 Glomerular filtration rate (creatinine); BRCA cis rs2668423 0.502 rs7254913 chr19:1388320 A/G cg02639931 chr19:1387894 NDUFS7 0.88 27.63 0.74 3.6e-111 Nonalcoholic fatty liver disease; BRCA cis rs9399137 0.507 rs12664898 chr6:135288663 T/C cg22676075 chr6:135203613 NA 0.45 8.73 0.33 2.18e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg08470875 chr2:26401718 FAM59B 0.77 11.99 0.43 4.89e-30 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs11944855 chr4:99068258 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs8177179 0.967 rs6439434 chr3:133450371 T/G cg16262614 chr3:133464971 TF 0.24 7.91 0.3 1.15e-14 Iron status biomarkers (transferrin levels); BRCA cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs8114671 0.804 rs3803936 chr20:33632775 T/C cg07148914 chr20:33460835 GGT7 -0.42 -9.03 -0.34 1.99e-18 Height; BRCA cis rs6463523 0.933 rs4724821 chr7:762544 C/T cg11064039 chr7:766100 PRKAR1B;HEATR2 0.91 22.85 0.67 6.4e-85 Subjective well-being; BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg26314531 chr2:26401878 FAM59B -0.65 -10.97 -0.4 8.96e-26 Gut microbiome composition (summer); BRCA cis rs6089584 0.627 rs55875402 chr20:60559925 G/A cg06108461 chr20:60628389 TAF4 -0.64 -13.19 -0.46 2.75e-35 Body mass index; BRCA cis rs9399135 0.933 rs28384512 chr6:135376232 C/T cg24558204 chr6:135376177 HBS1L 0.44 12.16 0.43 9.19e-31 Red blood cell count; BRCA cis rs6714710 0.603 rs17489984 chr2:98421364 A/G cg26665480 chr2:98280029 ACTR1B 0.6 13.83 0.48 2.95e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs9467773 0.935 rs11752946 chr6:26560364 C/A cg09904177 chr6:26538194 HMGN4 0.51 14.33 0.49 1.38e-40 Intelligence (multi-trait analysis); BRCA cis rs2439831 0.850 rs2228368 chr15:44102010 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.49 9.38 0.35 1.17e-19 Lung cancer in ever smokers; BRCA cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.91 -0.33 5.22e-18 Alzheimer's disease (late onset); BRCA cis rs2836974 0.800 rs73221174 chr21:40540939 T/C cg17971929 chr21:40555470 PSMG1 0.77 17.88 0.58 2.89e-58 Cognitive function; BRCA cis rs1003719 0.751 rs7280371 chr21:38450008 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.61 14.25 0.49 3.28e-40 Eye color traits; BRCA cis rs2985684 0.894 rs6572585 chr14:50021075 A/G cg04989706 chr14:50066350 PPIL5 -0.45 -8.69 -0.33 3.06e-17 Carotid intima media thickness; BRCA trans rs1459104 0.866 rs67929427 chr11:54824182 C/T cg15704280 chr7:45808275 SEPT13 0.63 8.25 0.31 8.87e-16 Body mass index; BRCA cis rs1707322 1.000 rs12077546 chr1:46431806 C/T cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.27e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs208515 0.525 rs10944871 chr6:66690306 A/G cg07460842 chr6:66804631 NA 0.9 16.73 0.55 2.16e-52 Exhaled nitric oxide levels; BRCA trans rs3733585 0.579 rs4235353 chr4:10122934 C/T cg26043149 chr18:55253948 FECH -0.38 -7.92 -0.3 1.09e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg04450456 chr4:17643702 FAM184B 0.33 9.51 0.35 3.8e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35306767 0.714 rs66797613 chr10:1090469 C/T cg10556349 chr10:835070 NA 0.59 8.31 0.31 5.59e-16 Eosinophil percentage of granulocytes; BRCA cis rs4631830 0.832 rs11005089 chr10:51510813 C/A cg20129853 chr10:51489980 NA 0.3 8.01 0.3 5.37e-15 Prostate-specific antigen levels; BRCA cis rs11955398 0.583 rs7719726 chr5:59949537 T/C cg02684056 chr5:59996105 DEPDC1B 0.38 8.83 0.33 9.8e-18 Intelligence (multi-trait analysis); BRCA cis rs76025697 1 rs76025697 chr5:179184488 G/A cg14593053 chr5:179126677 CANX 0.4 10.15 0.37 1.49e-22 Granulocyte percentage of myeloid white cells;Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Neutrophil count;Granulocyte count; BRCA cis rs7086627 0.506 rs10749575 chr10:82136921 C/T cg01528321 chr10:82214614 TSPAN14 0.62 13.05 0.46 1.07e-34 Post bronchodilator FEV1; BRCA cis rs7809950 0.678 rs75617662 chr7:107030439 G/A cg23024343 chr7:107201750 COG5 -0.49 -9.73 -0.36 5.87e-21 Coronary artery disease; BRCA cis rs34779708 0.931 rs11010125 chr10:35502953 A/G cg03585969 chr10:35415529 CREM 0.49 10.27 0.38 5.04e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1580019 0.587 rs6972365 chr7:32548931 T/A cg06627557 chr7:32535165 LSM5;AVL9 1.06 30.03 0.77 3.03e-124 Cognitive ability; BRCA trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs61201557 chr8:58138370 T/C cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs9392556 0.829 rs613260 chr6:4120567 C/G cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -8.2 -0.31 1.37e-15 Blood metabolite levels; BRCA cis rs6558530 0.692 rs6558522 chr8:1702370 C/G cg19131313 chr8:1704013 NA 0.38 7.97 0.3 7.46e-15 Systolic blood pressure; BRCA cis rs765787 0.530 rs12440321 chr15:45529385 G/A cg15395560 chr15:45543142 SLC28A2 -0.29 -7.89 -0.3 1.27e-14 Uric acid levels; BRCA cis rs3784262 0.679 rs4238326 chr15:58336000 C/T cg12031962 chr15:58353849 ALDH1A2 0.55 14.07 0.49 2.37e-39 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg04025307 chr7:1156635 C7orf50 0.59 9.31 0.35 2e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg09060608 chr5:178986726 RUFY1 0.56 14.09 0.49 1.86e-39 Lung cancer; BRCA cis rs11229555 0.645 rs7945992 chr11:58187755 T/A cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs36052053 0.908 rs71558364 chr6:109616239 A/T cg12927641 chr6:109611667 NA -0.51 -7.9 -0.3 1.26e-14 Red cell distribution width; BRCA cis rs9790314 0.747 rs9990115 chr3:160838412 C/G cg03342759 chr3:160939853 NMD3 -0.53 -10.33 -0.38 2.95e-23 Morning vs. evening chronotype; BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.93 0.33 4.4e-18 Tonsillectomy; BRCA cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs7584330 0.910 rs880930 chr2:238396872 G/C cg14458575 chr2:238380390 NA 0.59 13.48 0.47 1.21e-36 Prostate cancer; BRCA cis rs6089829 0.816 rs6062397 chr20:61668268 A/G cg08045932 chr20:61659980 NA 0.5 11.5 0.41 5.92e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg26608667 chr7:1196370 ZFAND2A 0.37 8.34 0.31 4.57e-16 Longevity;Endometriosis; BRCA cis rs2806561 1.000 rs1757044 chr1:23515631 T/C cg19743168 chr1:23544995 NA 0.42 10.41 0.38 1.5e-23 Height; BRCA cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg24130564 chr14:104152367 KLC1 0.36 8.07 0.3 3.37e-15 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg20701182 chr2:24300061 SF3B14 0.68 12.9 0.45 5.2e-34 Lymphocyte counts; BRCA cis rs12701220 0.894 rs13224488 chr7:1052353 C/A cg02733842 chr7:1102375 C7orf50 -0.72 -12.42 -0.44 7.02e-32 Bronchopulmonary dysplasia; BRCA trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg23505145 chr19:12996616 KLF1 0.54 12.17 0.43 8.48e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs7264396 0.635 rs6121102 chr20:34544274 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.39 8.29 0.31 6.64e-16 Total cholesterol levels; BRCA cis rs897080 0.516 rs1067393 chr2:44638832 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.8 0.33 1.28e-17 Height; BRCA cis rs2072499 0.750 rs7534339 chr1:156156219 A/G cg25208724 chr1:156163844 SLC25A44 0.89 17.57 0.57 1.08e-56 Testicular germ cell tumor; BRCA cis rs8180040 0.966 rs62260711 chr3:47564491 G/C cg16586182 chr3:47516702 SCAP 0.63 13.66 0.48 1.8e-37 Colorectal cancer; BRCA cis rs1832871 0.672 rs11751553 chr6:158774750 C/T cg07165851 chr6:158734300 TULP4 -0.62 -12.31 -0.44 2.08e-31 Height; BRCA cis rs2742234 0.541 rs871763 chr10:43734188 C/T cg02780029 chr10:43622663 RET 0.35 7.85 0.3 1.7e-14 Hirschsprung disease; BRCA cis rs12762955 0.561 rs6560863 chr10:1013535 C/A cg20503657 chr10:835505 NA -0.53 -10.06 -0.37 3.31e-22 Response to angiotensin II receptor blocker therapy; BRCA cis rs28699126 0.504 rs1056632 chr2:26512733 T/G cg08470875 chr2:26401718 FAM59B 0.75 11.81 0.42 3.12e-29 Mean corpuscular hemoglobin; BRCA cis rs13256369 0.756 rs13280759 chr8:8562995 G/T cg00074818 chr8:8560427 CLDN23 0.39 8.44 0.32 2.11e-16 Obesity-related traits; BRCA cis rs12200560 0.505 rs211178 chr6:97074094 T/A cg06623918 chr6:96969491 KIAA0776 0.53 12.64 0.45 7.46e-33 Coronary heart disease; BRCA cis rs7914558 0.966 rs746293 chr10:104897254 G/T cg04362960 chr10:104952993 NT5C2 0.44 10.8 0.39 4.26e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg07636037 chr3:49044803 WDR6 -0.67 -13.08 -0.46 7.91e-35 Menarche (age at onset); BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24531977 chr5:56204891 C5orf35 -0.86 -16.86 -0.55 4.81e-53 Initial pursuit acceleration; BRCA cis rs2762353 1.000 rs2762353 chr6:25794431 A/G cg12310025 chr6:25882481 NA -0.5 -11.91 -0.43 1.13e-29 Blood metabolite levels; BRCA cis rs2204008 0.774 rs11615665 chr12:38328162 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.33 0.38 3.05e-23 Bladder cancer; BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 17.01 0.56 8.75e-54 Alzheimer's disease; BRCA cis rs11608355 0.515 rs4766606 chr12:109934390 C/G cg05360138 chr12:110035743 NA 0.72 13.3 0.47 8.56e-36 Neuroticism; BRCA cis rs8114671 0.804 rs6088666 chr20:33564570 A/G cg24642439 chr20:33292090 TP53INP2 0.42 8.39 0.32 3.12e-16 Height; BRCA cis rs60871478 0.945 rs4719279 chr7:813618 T/C cg05535760 chr7:792225 HEATR2 0.69 12.46 0.44 4.7e-32 Cerebrospinal P-tau181p levels; BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg00814883 chr7:100076585 TSC22D4 -0.54 -11.83 -0.42 2.56e-29 Platelet count; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.43 9.59 0.35 1.8899999999999998e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.25e-24 Motion sickness; BRCA cis rs4727027 0.933 rs1058059 chr7:148879134 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.18 0.4 1.22e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7312933 0.934 rs11181289 chr12:42402342 C/T cg01256987 chr12:42539512 GXYLT1 -0.57 -11.42 -0.41 1.26e-27 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7666738 0.791 rs10033994 chr4:98969582 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.93 -0.43 9.31e-30 Personality dimensions; BRCA cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg06766960 chr11:133703094 NA -0.6 -13.18 -0.46 2.93e-35 Childhood ear infection; BRCA cis rs2617583 0.967 rs2652509 chr5:1448247 A/G cg07151155 chr5:1473589 LPCAT1 -0.37 -8.06 -0.3 3.75e-15 Breast cancer; BRCA cis rs10754283 0.967 rs10801760 chr1:90113824 G/A cg21401794 chr1:90099060 LRRC8C 0.46 11.06 0.4 4.04e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs637571 0.546 rs11227309 chr11:65584512 A/C cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -9.01 -0.34 2.3e-18 Eosinophil percentage of white cells; BRCA cis rs13256369 0.756 rs13282580 chr8:8562903 C/T cg18904891 chr8:8559673 CLDN23 0.65 12.88 0.45 6.78e-34 Obesity-related traits; BRCA cis rs1008375 0.932 rs13127157 chr4:17618049 A/G cg02297831 chr4:17616191 MED28 -0.39 -8.15 -0.31 1.99e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6570726 0.875 rs373313 chr6:145857791 T/C cg23711669 chr6:146136114 FBXO30 0.64 14.9 0.51 2.57e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs992157 0.717 rs3817266 chr2:219142594 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.22 -0.41 8.71e-27 Colorectal cancer; BRCA cis rs9649213 0.593 rs11766808 chr7:97915376 A/G cg24562669 chr7:97807699 LMTK2 0.45 12.28 0.44 2.88e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs4819052 0.851 rs2838831 chr21:46664775 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.55 10.41 0.38 1.54e-23 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs9388451 0.626 rs1935983 chr6:126068914 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.57 -14.22 -0.49 4.54e-40 Brugada syndrome; BRCA cis rs2070488 0.775 rs2051213 chr3:38560254 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.61 15.91 0.53 2.78e-48 Electrocardiographic conduction measures; BRCA cis rs514406 0.929 rs557847 chr1:53333116 A/G cg25767906 chr1:53392781 SCP2 -0.38 -8.49 -0.32 1.48e-16 Monocyte count; BRCA cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11270836 1 rs11270836 chr4:38625915 T/TACATTATGTCATTTCACA cg18361445 chr4:38666374 KLF3;FLJ13197 0.57 10.99 0.4 7.41e-26 Mumps; BRCA cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs6582630 0.519 rs10880629 chr12:38533611 T/G cg13010199 chr12:38710504 ALG10B 0.52 10.91 0.4 1.58e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs9325144 0.647 rs11168819 chr12:39011082 C/A cg26384229 chr12:38710491 ALG10B -0.48 -11.28 -0.41 5.03e-27 Morning vs. evening chronotype; BRCA cis rs1865760 1.000 rs56118523 chr6:25908975 A/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.43 0.38 1.29e-23 Height; BRCA cis rs7766436 0.885 rs13198355 chr6:22577119 C/G cg13666174 chr6:22585274 NA -0.45 -9.68 -0.36 9.33e-21 Coronary artery disease; BRCA cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg13902645 chr11:5959945 NA -0.47 -9.97 -0.37 7.7e-22 DNA methylation (variation); BRCA cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.89 0.43 1.35e-29 Hip circumference adjusted for BMI; BRCA cis rs7772486 0.727 rs10447449 chr6:146138707 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.68 -0.32 3.22e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg00071950 chr4:10020882 SLC2A9 0.47 10.94 0.4 1.18e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6088590 1.000 rs6088590 chr20:33313566 T/C cg06115741 chr20:33292138 TP53INP2 0.48 10.68 0.39 1.25e-24 Coronary artery disease; BRCA cis rs6964587 1.000 rs6969981 chr7:91689461 G/C cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs2288073 0.965 rs10199334 chr2:24392618 T/C cg26838691 chr2:24397539 C2orf84 -0.54 -9.54 -0.35 2.89e-20 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs722599 0.748 rs2537824 chr14:75367349 T/C cg08847533 chr14:75593920 NEK9 -0.44 -7.96 -0.3 8.16e-15 IgG glycosylation; BRCA cis rs68170813 0.527 rs75382408 chr7:107010406 C/T cg02696742 chr7:106810147 HBP1 -0.49 -8.29 -0.31 6.49e-16 Coronary artery disease; BRCA cis rs875971 0.862 rs778702 chr7:65864835 G/A cg11764359 chr7:65958608 NA 0.77 17.35 0.57 1.46e-55 Aortic root size; BRCA cis rs8180040 0.620 rs6768722 chr3:47079112 G/A cg27129171 chr3:47204927 SETD2 0.71 17.08 0.56 3.81e-54 Colorectal cancer; BRCA cis rs703842 0.928 rs724834 chr12:58180416 G/C cg00677455 chr12:58241039 CTDSP2 0.62 13.96 0.48 7.36e-39 Multiple sclerosis; BRCA cis rs10785877 0.570 rs7043538 chr9:137109051 A/G cg21243944 chr9:137118148 NA 0.3 7.93 0.3 9.81e-15 Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin); BRCA trans rs7613875 0.663 rs6762477 chr3:50093209 G/A cg21659725 chr3:3221576 CRBN -0.33 -7.93 -0.3 9.93e-15 Body mass index; BRCA cis rs1448094 0.512 rs7957170 chr12:86243282 A/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.31 -0.35 2.09e-19 Major depressive disorder; BRCA cis rs1008375 0.800 rs62296338 chr4:17613425 G/T cg15017067 chr4:17643749 FAM184B 0.29 9.01 0.34 2.37e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2797160 0.967 rs984041 chr6:126021328 A/T cg05901451 chr6:126070800 HEY2 0.39 9.51 0.35 3.95e-20 Endometrial cancer; BRCA cis rs4478858 0.735 rs10914361 chr1:31817542 T/G cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs2652834 0.851 rs4238370 chr15:63347363 T/G cg05507819 chr15:63340323 TPM1 0.47 8.38 0.31 3.31e-16 HDL cholesterol; BRCA trans rs3733585 0.699 rs6449157 chr4:9960442 G/A cg26043149 chr18:55253948 FECH -0.37 -8.12 -0.31 2.34e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg24531977 chr5:56204891 C5orf35 -0.87 -18.47 -0.59 2.43e-61 Initial pursuit acceleration; BRCA cis rs7666738 0.791 rs62318641 chr4:98816964 T/C cg05340658 chr4:99064831 C4orf37 0.61 14.59 0.5 8.39e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.958 rs36070 chr5:148417240 T/C cg12140854 chr5:148520817 ABLIM3 -0.43 -9.07 -0.34 1.41e-18 Breast cancer; BRCA cis rs13191362 1.000 rs13212608 chr6:163032128 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.58 0.32 7.26e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6964587 1.000 rs12540055 chr7:91707921 A/G cg17063962 chr7:91808500 NA 0.51 11.98 0.43 5.88e-30 Breast cancer; BRCA cis rs853679 0.546 rs200981 chr6:27833174 A/G cg26587870 chr6:27730563 NA -0.53 -8.14 -0.31 2.13e-15 Depression; BRCA cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg24642439 chr20:33292090 TP53INP2 0.52 11.43 0.41 1.2e-27 Glomerular filtration rate (creatinine); BRCA cis rs11229555 0.645 rs12269745 chr11:58176875 G/A cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12618769 0.597 rs3769727 chr2:99103318 C/T cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs1707322 1.000 rs4524994 chr1:46370263 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.89 0.4 1.9e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs10470951 chr4:99037051 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg14004847 chr7:1930337 MAD1L1 -0.41 -8.17 -0.31 1.61e-15 Schizophrenia; BRCA cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg22903657 chr4:1355424 KIAA1530 -0.37 -8.11 -0.31 2.67e-15 Obesity-related traits; BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg08742575 chr21:47604166 C21orf56 0.41 8.28 0.31 7.21e-16 Testicular germ cell tumor; BRCA cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.69 17.73 0.57 1.77e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.53 -9.87 -0.36 1.78e-21 Gut microbiome composition (summer); BRCA cis rs9467773 1.000 rs1056667 chr6:26510564 T/C cg09904177 chr6:26538194 HMGN4 0.56 18.26 0.59 3.11e-60 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.607 rs13076398 chr3:52573096 G/A cg10802521 chr3:52805072 NEK4 -0.31 -8.11 -0.31 2.57e-15 Electroencephalogram traits; BRCA cis rs10870270 1.000 rs10430617 chr10:133748889 T/C cg08754478 chr10:133766260 PPP2R2D -0.68 -13.8 -0.48 4.25e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6977660 0.714 rs9969381 chr7:19827454 C/T cg07541023 chr7:19748670 TWISTNB 0.57 9.79 0.36 3.58e-21 Thyroid stimulating hormone; BRCA cis rs7666738 0.830 rs35822567 chr4:98654138 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.59 0.5 7.73e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs4363385 0.818 rs378010 chr1:153007987 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -8.94 -0.33 4.25e-18 Inflammatory skin disease; BRCA cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg21926612 chr6:163149169 PACRG;PARK2 -0.51 -10.03 -0.37 4.32e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3767633 0.800 rs2880055 chr1:161922365 C/T cg09175582 chr1:161736000 ATF6 0.46 8.1 0.31 2.87e-15 IgG glycosylation; BRCA cis rs8023845 1.000 rs3759843 chr15:40453075 A/G cg20259534 chr15:40453036 BUB1B -0.59 -9.04 -0.34 1.79e-18 Chronic lymphocytic leukemia; BRCA cis rs9814567 1.000 rs1534025 chr3:134313304 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.63 0.61 1.63e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg03161606 chr19:29218774 NA 0.46 8.15 0.31 1.91e-15 Methadone dose in opioid dependence; BRCA trans rs11098499 0.615 rs28551750 chr4:120264901 C/T cg25214090 chr10:38739885 LOC399744 0.42 9.67 0.36 9.88e-21 Corneal astigmatism; BRCA cis rs7264396 0.563 rs6060592 chr20:34352414 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.53 -0.42 4.34e-28 Total cholesterol levels; BRCA cis rs1401999 0.714 rs1533683 chr3:183635488 C/T cg01324343 chr3:183735012 ABCC5 0.67 16.11 0.54 3.04e-49 Anterior chamber depth; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 16.93 0.56 2.14e-53 Platelet count; BRCA cis rs875971 0.540 rs736270 chr7:65428822 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.44 9.9 0.36 1.33e-21 Aortic root size; BRCA cis rs11229555 0.609 rs7128459 chr11:58179291 C/T cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1568889 0.838 rs10835299 chr11:28277693 A/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.78 -20.53 -0.63 2.57e-72 Bipolar disorder; BRCA cis rs4363385 0.818 rs1415965 chr1:153002750 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.81 -0.33 1.17e-17 Inflammatory skin disease; BRCA cis rs2180341 0.680 rs9388554 chr6:127576234 C/G cg27446573 chr6:127587934 RNF146 0.69 15.17 0.51 1.23e-44 Breast cancer; BRCA cis rs4713118 0.513 rs149945 chr6:28002853 T/C cg10876282 chr6:28092338 ZSCAN16 0.41 8.13 0.31 2.17e-15 Parkinson's disease; BRCA cis rs2235642 0.717 rs2236269 chr16:1652614 T/A cg26528668 chr16:1614120 IFT140 0.35 7.94 0.3 8.89e-15 Coronary artery disease; BRCA cis rs698813 0.674 rs4952707 chr2:44500683 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.75 0.33 1.93e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg16145915 chr7:1198662 ZFAND2A -0.74 -22.42 -0.66 1.37e-82 Longevity;Endometriosis; BRCA cis rs12478296 0.591 rs12468297 chr2:242996474 A/G cg06360820 chr2:242988706 NA -0.64 -13.12 -0.46 5.48e-35 Obesity-related traits; BRCA cis rs10206020 0.759 rs11903889 chr2:1576601 C/T cg12573674 chr2:1569213 NA -0.58 -12.54 -0.44 2.11e-32 IgG glycosylation; BRCA cis rs875971 0.862 rs12698521 chr7:65939489 T/C cg18876405 chr7:65276391 NA 0.55 13.18 0.46 3.03e-35 Aortic root size; BRCA cis rs17376456 0.825 rs10038831 chr5:93124115 C/T cg25358565 chr5:93447407 FAM172A 1.15 17.91 0.58 1.94e-58 Diabetic retinopathy; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.12 25.97 0.72 4.89e-102 Platelet count; BRCA cis rs832540 0.512 rs33320 chr5:56206529 C/T cg12311346 chr5:56204834 C5orf35 -0.49 -9.73 -0.36 6.07e-21 Coronary artery disease; BRCA cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg05347473 chr6:146136440 FBXO30 0.39 7.93 0.3 9.59e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.810 rs7612908 chr3:10089148 A/G cg08888203 chr3:10149979 C3orf24 0.68 14.48 0.5 2.55e-41 Alzheimer's disease; BRCA cis rs1215050 0.791 rs165237 chr4:98712029 T/C cg05340658 chr4:99064831 C4orf37 0.45 10.41 0.38 1.48e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs873946 0.590 rs7071777 chr10:134559976 T/A cg18305652 chr10:134549665 INPP5A 0.46 10.57 0.39 3.6e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6964587 1.000 rs6964587 chr7:91630620 G/T cg01689657 chr7:91764605 CYP51A1 0.21 7.85 0.3 1.74e-14 Breast cancer; BRCA cis rs8072100 0.544 rs7214993 chr17:45386797 C/G cg08085267 chr17:45401833 C17orf57 -0.62 -13.1 -0.46 6.95e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7666738 0.830 rs3907021 chr4:99038668 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 4.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs36051895 0.589 rs10491650 chr9:5203054 C/T cg02405213 chr9:5042618 JAK2 0.43 8.41 0.32 2.67e-16 Pediatric autoimmune diseases; BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg00814883 chr7:100076585 TSC22D4 -0.49 -9.99 -0.37 6.05e-22 Platelet count; BRCA trans rs6598955 0.671 rs10159433 chr1:26618370 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.5e-50 Obesity-related traits; BRCA cis rs10752881 1.000 rs4402094 chr1:182986441 G/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.17e-52 Colorectal cancer; BRCA cis rs1476679 0.962 rs34995835 chr7:99990364 T/G cg19116668 chr7:99932089 PMS2L1 0.48 8.65 0.32 4.01e-17 Alzheimer's disease (late onset); BRCA cis rs7560272 0.723 rs2421548 chr2:73641240 A/G cg20560298 chr2:73613845 ALMS1 0.42 11.33 0.41 2.96e-27 Schizophrenia; BRCA cis rs939658 0.805 rs8024813 chr15:79427260 A/G cg17916960 chr15:79447300 NA -0.46 -11.52 -0.41 4.77e-28 Refractive error; BRCA cis rs4363385 0.747 rs1129655 chr1:152958267 T/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.07 -0.34 1.4e-18 Inflammatory skin disease; BRCA cis rs9399137 0.529 rs7739722 chr6:135282225 T/C cg24558204 chr6:135376177 HBS1L 0.53 14.81 0.51 7.1e-43 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg14582100 chr15:45693742 SPATA5L1 0.37 12.14 0.43 1.1e-30 Homoarginine levels; BRCA cis rs2832191 0.636 rs8131295 chr21:30516819 A/T cg24692254 chr21:30365293 RNF160 -0.46 -10.16 -0.37 1.36e-22 Dental caries; BRCA cis rs7520050 0.807 rs6671802 chr1:46124663 A/G cg24296786 chr1:45957014 TESK2 -0.46 -10.54 -0.38 4.86e-24 Red blood cell count;Reticulocyte count; BRCA cis rs701145 0.585 rs1960241 chr3:153858398 T/C cg17054900 chr3:154042577 DHX36 0.55 9.23 0.34 3.79e-19 Coronary artery disease; BRCA cis rs9467773 1.000 rs9467783 chr6:26542894 C/T cg09904177 chr6:26538194 HMGN4 0.56 18.3 0.59 1.77e-60 Intelligence (multi-trait analysis); BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.8 0.42 3.13e-29 Tonsillectomy; BRCA cis rs7726839 0.561 rs72703044 chr5:579737 G/A cg09021430 chr5:549028 NA -0.64 -15.17 -0.51 1.26e-44 Obesity-related traits; BRCA cis rs10744422 1.000 rs1587856 chr12:123342229 A/G cg25930673 chr12:123319894 HIP1R -0.53 -8.14 -0.31 2.06e-15 Schizophrenia; BRCA cis rs7119 0.717 rs10519167 chr15:77723027 G/T cg17802220 chr15:77601643 NA -0.45 -10.12 -0.37 1.96e-22 Type 2 diabetes; BRCA cis rs17270561 0.609 rs9393662 chr6:25739670 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.8 0.33 1.28e-17 Iron status biomarkers; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg25036284 chr2:26402008 FAM59B 0.85 15.12 0.51 2.13e-44 Gut microbiome composition (summer); BRCA cis rs8044868 0.530 rs2288002 chr16:72057282 A/G cg16558253 chr16:72132732 DHX38 -0.39 -9.51 -0.35 3.86e-20 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs6815814 0.950 rs11722813 chr4:38810769 C/T cg06935464 chr4:38784597 TLR10 0.5 8.21 0.31 1.24e-15 Breast cancer; BRCA cis rs9368481 0.761 rs9357028 chr6:26967224 T/G cg12292205 chr6:26970375 C6orf41 -0.8 -19.68 -0.61 9.64e-68 Autism spectrum disorder or schizophrenia; BRCA cis rs425277 0.585 rs364677 chr1:2071765 A/G cg04315214 chr1:2043799 PRKCZ 0.47 12.86 0.45 8.3e-34 Height; BRCA cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.715 rs2838353 chr21:45119228 C/T cg04455712 chr21:45112962 RRP1B 0.44 12.31 0.44 2.18e-31 Mean corpuscular volume; BRCA trans rs1005277 0.579 rs176886 chr10:38403974 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.51 -0.32 1.2e-16 Extrinsic epigenetic age acceleration; BRCA cis rs6598955 0.671 rs17257169 chr1:26570009 C/T cg04990556 chr1:26633338 UBXN11 0.55 8.44 0.32 2.2e-16 Obesity-related traits; BRCA cis rs2197308 0.692 rs1904964 chr12:37933241 T/A cg26384229 chr12:38710491 ALG10B 0.7 15.82 0.53 8.18e-48 Morning vs. evening chronotype; BRCA cis rs6496044 0.568 rs6496040 chr15:86064129 C/G cg10818794 chr15:86012489 AKAP13 -0.29 -7.91 -0.3 1.1e-14 Interstitial lung disease; BRCA cis rs9815354 0.723 rs79741604 chr3:41947321 C/T cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg14019146 chr3:50243930 SLC38A3 -0.57 -11.9 -0.43 1.24e-29 Intelligence (multi-trait analysis); BRCA cis rs11605275 1.000 rs76399107 chr11:20029148 C/T cg14835545 chr11:20032148 NAV2 -0.58 -8.68 -0.32 3.3e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4665809 0.556 rs4665322 chr2:26434605 C/G cg26314531 chr2:26401878 FAM59B -0.88 -16.41 -0.54 9.34e-51 Gut microbiome composition (summer); BRCA cis rs7552404 0.590 rs1565717 chr1:76320441 T/C cg03433033 chr1:76189801 ACADM -0.59 -11.81 -0.42 3.04e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4595586 0.545 rs1839402 chr12:39371615 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.25 0.34 3.44e-19 Morning vs. evening chronotype; BRCA cis rs36051895 0.589 rs10491651 chr9:5200060 A/G cg02405213 chr9:5042618 JAK2 -0.42 -7.98 -0.3 6.6e-15 Pediatric autoimmune diseases; BRCA cis rs1371614 0.635 rs4665923 chr2:27138911 C/T cg12368169 chr2:27073192 DPYSL5 0.28 8.45 0.32 2.04e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs3768617 0.782 rs12146099 chr1:182968079 G/A ch.1.3577855R chr1:183094577 LAMC1 0.41 8.52 0.32 1.12e-16 Fuchs's corneal dystrophy; BRCA cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs11249608 0.548 rs62393072 chr5:178450056 C/T cg21905437 chr5:178450457 ZNF879 0.54 11.23 0.41 7.64e-27 Pubertal anthropometrics; BRCA cis rs939658 0.805 rs11634679 chr15:79432475 T/C cg17916960 chr15:79447300 NA -0.45 -11.23 -0.41 7.81e-27 Refractive error; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg04025307 chr7:1156635 C7orf50 0.59 9.46 0.35 5.74e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg00080972 chr5:178986291 RUFY1 0.37 8.43 0.32 2.37e-16 Lung cancer; BRCA trans rs877282 0.898 rs11253348 chr10:765852 C/T cg22713356 chr15:30763199 NA 1.3 24.11 0.69 7.71e-92 Uric acid levels; BRCA cis rs12142240 0.698 rs56358525 chr1:46849520 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.62 0.36 1.49e-20 Menopause (age at onset); BRCA cis rs7520050 1.000 rs785473 chr1:46516863 T/C cg24296786 chr1:45957014 TESK2 0.41 9.22 0.34 4.28e-19 Red blood cell count;Reticulocyte count; BRCA cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg23992470 chr4:843637 GAK 0.48 8.12 0.31 2.42e-15 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.685 rs6690926 chr1:46134978 T/C cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs9650657 0.537 rs7016385 chr8:10779472 A/G cg15556689 chr8:8085844 FLJ10661 0.36 9.21 0.34 4.58e-19 Neuroticism; BRCA cis rs4285028 0.747 rs7623901 chr3:121529011 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.89 16.82 0.55 7.5e-53 Multiple sclerosis; BRCA cis rs6582630 0.519 rs11495373 chr12:38275470 T/C cg13010199 chr12:38710504 ALG10B 0.44 8.97 0.33 3.33e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs1577917 0.696 rs10806334 chr6:86439329 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.57 -0.45 1.6e-32 Response to antipsychotic treatment; BRCA trans rs10506458 1.000 rs1009539 chr12:63414655 A/G cg03429785 chr15:59498649 MYO1E;LDHAL6B 1.11 18.71 0.59 1.23e-62 Hemostatic factors and hematological phenotypes; BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.79 -0.42 3.69e-29 Gut microbiome composition (summer); BRCA cis rs875971 0.545 rs75577046 chr7:65958716 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.89 0.36 1.45e-21 Aortic root size; BRCA cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.72 -10.47 -0.38 8.67e-24 Schizophrenia; BRCA cis rs67478160 0.643 rs876002 chr14:104239697 G/A cg26031613 chr14:104095156 KLC1 -0.43 -8.56 -0.32 8.44e-17 Schizophrenia; BRCA cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg04450456 chr4:17643702 FAM184B 0.36 9.7 0.36 7.64e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9341808 0.727 rs4706834 chr6:81012605 G/T cg08355045 chr6:80787529 NA 0.35 9.01 0.34 2.29e-18 Sitting height ratio; BRCA cis rs7824557 0.564 rs7839307 chr8:11198792 A/G cg21775007 chr8:11205619 TDH 0.7 17.27 0.56 3.98e-55 Retinal vascular caliber; BRCA cis rs2228479 0.764 rs7186976 chr16:89961593 A/G cg00800038 chr16:89945340 TCF25 -0.7 -10.58 -0.39 3.23e-24 Skin colour saturation; BRCA cis rs4862750 0.832 rs9995958 chr4:187901764 G/A cg22105103 chr4:187893119 NA 0.41 13.33 0.47 5.9e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg19077165 chr18:44547161 KATNAL2 -0.56 -12.24 -0.44 4.24e-31 Personality dimensions; BRCA cis rs36051895 0.632 rs12001334 chr9:5152604 C/A cg02405213 chr9:5042618 JAK2 -0.44 -8.57 -0.32 7.48e-17 Pediatric autoimmune diseases; BRCA cis rs9790314 1.000 rs2218803 chr3:161047973 T/G cg03342759 chr3:160939853 NMD3 -0.63 -13.31 -0.47 7.41e-36 Morning vs. evening chronotype; BRCA cis rs6952808 0.723 rs60432611 chr7:2029629 G/C cg00106254 chr7:1943704 MAD1L1 -0.46 -12.31 -0.44 2.1e-31 Bipolar disorder and schizophrenia; BRCA cis rs12042938 0.905 rs823160 chr1:231776636 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.37 8.16 0.31 1.82e-15 Neuranatomic and neurocognitive phenotypes; BRCA cis rs897984 0.572 rs4889526 chr16:31030344 C/A cg02466173 chr16:30829666 NA -0.43 -9.74 -0.36 5.48e-21 Dementia with Lewy bodies; BRCA cis rs7399018 0.643 rs6580810 chr12:51610478 C/T cg20712883 chr12:51590929 POU6F1 0.39 7.93 0.3 9.7e-15 Cisplatin-induced ototoxicity; BRCA cis rs4665809 0.590 rs72809668 chr2:26467653 C/T cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs1153858 1.000 rs16942568 chr15:45677390 T/C cg14582100 chr15:45693742 SPATA5L1 0.37 11.89 0.43 1.39e-29 Homoarginine levels; BRCA cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg08885076 chr2:99613938 TSGA10 -0.42 -9.82 -0.36 2.68e-21 Chronic sinus infection; BRCA cis rs10838687 0.867 rs2633082 chr11:47248050 C/G cg25783544 chr11:47291846 MADD -0.42 -8.3 -0.31 6.1e-16 Proinsulin levels; BRCA cis rs5167 0.506 rs35193317 chr19:45470344 C/T cg13119609 chr19:45449297 APOC2 -0.53 -14.74 -0.5 1.56e-42 Blood protein levels; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg16590910 chr6:42928470 GNMT 0.41 9.15 0.34 7.36e-19 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.543 rs801191 chr7:66032955 G/A cg18876405 chr7:65276391 NA -0.57 -13.67 -0.48 1.64e-37 Aortic root size; BRCA cis rs4481887 0.927 rs6678798 chr1:248476617 C/T cg13385794 chr1:248469461 NA 0.27 7.85 0.3 1.75e-14 Common traits (Other); BRCA cis rs765787 0.530 rs12913123 chr15:45516425 C/T cg24006582 chr15:45444508 DUOX1 0.55 10.71 0.39 9.9e-25 Uric acid levels; BRCA cis rs3007729 0.509 rs6665151 chr1:18800247 A/G cg04846421 chr1:18800208 NA -0.44 -10.78 -0.39 5.44e-25 Diabetic retinopathy; BRCA cis rs2075371 0.796 rs1978504 chr7:134006933 C/T cg11752832 chr7:134001865 SLC35B4 -0.5 -11.9 -0.43 1.25e-29 Mean platelet volume; BRCA cis rs17818399 0.547 rs35178974 chr2:46763898 T/C cg02822958 chr2:46747628 ATP6V1E2 0.64 11.66 0.42 1.34e-28 Height; BRCA cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg04025307 chr7:1156635 C7orf50 0.45 10.02 0.37 4.98e-22 Longevity;Endometriosis; BRCA cis rs11098499 0.644 rs28787668 chr4:120554687 G/A cg09307838 chr4:120376055 NA 0.59 12.29 0.44 2.66e-31 Corneal astigmatism; BRCA cis rs9469890 0.604 rs11756281 chr6:34503446 T/C cg14254433 chr6:34482411 PACSIN1 -0.44 -9.07 -0.34 1.44e-18 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs1577917 1.000 rs10455455 chr6:86670214 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -8.81 -0.33 1.19e-17 Response to antipsychotic treatment; BRCA cis rs7539409 0.651 rs7521788 chr1:84309320 G/T cg10977910 chr1:84465055 TTLL7 0.68 10.45 0.38 1.05e-23 Alzheimer's disease; BRCA cis rs7264396 0.887 rs224351 chr20:34052273 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.3 -0.31 6.37e-16 Total cholesterol levels; BRCA cis rs6429082 0.714 rs184108 chr1:235646160 A/G cg26050004 chr1:235667680 B3GALNT2 0.57 14.17 0.49 7.83e-40 Adiposity; BRCA cis rs1153858 1.000 rs1049503 chr15:45653707 T/C cg21132104 chr15:45694354 SPATA5L1 0.75 17.09 0.56 3.4e-54 Homoarginine levels; BRCA cis rs7086627 0.515 rs7078254 chr10:82212193 C/T cg01528321 chr10:82214614 TSPAN14 0.64 14.58 0.5 9.02e-42 Post bronchodilator FEV1; BRCA cis rs6938 0.534 rs4886636 chr15:75196176 G/A cg10253484 chr15:75165896 SCAMP2 -0.56 -11.67 -0.42 1.16e-28 Breast cancer; BRCA cis rs4690686 0.538 rs7436387 chr4:177257723 T/G cg17059388 chr4:177262070 NA 0.49 9.89 0.36 1.47e-21 Essential tremor; BRCA cis rs34779708 0.966 rs11010122 chr10:35493518 A/C cg03585969 chr10:35415529 CREM 0.49 10.38 0.38 2.0500000000000001e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg01283332 chr5:1856932 NA -0.35 -8.59 -0.32 6.56e-17 Cardiovascular disease risk factors; BRCA cis rs9814567 1.000 rs9864439 chr3:134298671 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.34 -0.61 6.06e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6547741 0.844 rs9941696 chr2:27920064 C/T cg27432699 chr2:27873401 GPN1 -0.52 -10.83 -0.39 3.2e-25 Oral cavity cancer; BRCA cis rs3008870 0.755 rs1535365 chr1:67497613 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.83 0.48 3.13e-38 Lymphocyte percentage of white cells; BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg08888203 chr3:10149979 C3orf24 0.65 11.86 0.42 1.89e-29 Alzheimer's disease; BRCA cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg05625103 chr10:2543513 NA 0.41 9.03 0.34 1.94e-18 Age-related hearing impairment; BRCA cis rs10267417 0.603 rs10281428 chr7:19857374 G/A cg07541023 chr7:19748670 TWISTNB 0.51 9.08 0.34 1.37e-18 Night sleep phenotypes; BRCA cis rs7412746 0.566 rs2864871 chr1:150766964 T/C cg15448220 chr1:150897856 SETDB1 0.36 8.2 0.31 1.27e-15 Melanoma; BRCA cis rs28735056 0.967 rs11662248 chr18:77619009 C/T cg20368463 chr18:77673604 PQLC1 -0.34 -8.06 -0.3 3.7e-15 Schizophrenia; BRCA cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg19077165 chr18:44547161 KATNAL2 -0.57 -12.4 -0.44 9.01e-32 Personality dimensions; BRCA cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg05347473 chr6:146136440 FBXO30 -0.61 -12.08 -0.43 2.04e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs397969 0.596 rs7209653 chr17:19882084 A/G cg13482628 chr17:19912719 NA 0.42 10.11 0.37 2.12e-22 Platelet count; BRCA cis rs4268898 0.552 rs7560342 chr2:24371691 T/C cg06627628 chr2:24431161 ITSN2 0.41 8.64 0.32 4.53e-17 Asthma; BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.21 0.43 5.69e-31 Platelet count; BRCA cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.84 0.62 1.29e-68 Cognitive function; BRCA cis rs2991971 0.967 rs7526665 chr1:46005832 G/T cg24296786 chr1:45957014 TESK2 0.59 14.37 0.49 9.24e-41 High light scatter reticulocyte count; BRCA trans rs6089829 0.926 rs6011552 chr20:61667894 T/C cg15934090 chr1:100435551 SLC35A3 0.37 8.22 0.31 1.14e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs1801251 1.000 rs3817311 chr2:233612557 C/T cg25237894 chr2:233734115 C2orf82 0.4 11.47 0.41 8.37e-28 Coronary artery disease; BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg12311346 chr5:56204834 C5orf35 -0.78 -15.99 -0.53 1.18e-48 Initial pursuit acceleration; BRCA cis rs68170813 0.559 rs12534676 chr7:106943640 G/A cg02696742 chr7:106810147 HBP1 -0.52 -8.46 -0.32 1.77e-16 Coronary artery disease; BRCA cis rs208520 0.690 rs9345764 chr6:66820597 C/T cg07460842 chr6:66804631 NA -1.0 -20.09 -0.62 5.87e-70 Exhaled nitric oxide output; BRCA cis rs7582180 0.676 rs4264577 chr2:100930662 T/C cg14675211 chr2:100938903 LONRF2 0.47 10.88 0.4 2.05e-25 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.680 rs3955310 chr2:26290828 T/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.12 -0.43 1.39e-30 Gut microbiome composition (summer); BRCA cis rs7809950 1.000 rs2237672 chr7:107131563 A/C cg23024343 chr7:107201750 COG5 -0.4 -9.3 -0.35 2.24e-19 Coronary artery disease; BRCA cis rs13082711 0.519 rs13091109 chr3:27229125 G/A cg02860705 chr3:27208620 NA 0.55 10.98 0.4 8.44e-26 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2204008 0.840 rs7136347 chr12:38453531 G/A cg26384229 chr12:38710491 ALG10B 0.77 17.59 0.57 8.61e-57 Bladder cancer; BRCA cis rs7727544 0.684 rs2516788 chr5:131715565 G/C cg24060327 chr5:131705240 SLC22A5 0.45 8.95 0.33 3.97e-18 Blood metabolite levels; BRCA cis rs939658 0.805 rs34478496 chr15:79440997 C/A cg17916960 chr15:79447300 NA -0.43 -10.98 -0.4 8.11e-26 Refractive error; BRCA cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.88 19.64 0.61 1.6e-67 Cognitive ability; BRCA cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.22e-41 Motion sickness; BRCA cis rs17818399 0.547 rs13020299 chr2:46758717 A/G cg02822958 chr2:46747628 ATP6V1E2 0.58 11.05 0.4 4.22e-26 Height; BRCA cis rs36051895 0.659 rs62543863 chr9:5085417 C/T cg02405213 chr9:5042618 JAK2 -0.54 -9.41 -0.35 8.61e-20 Pediatric autoimmune diseases; BRCA cis rs9653442 0.609 rs2576678 chr2:100704810 T/C cg22139774 chr2:100720529 AFF3 -0.3 -8.39 -0.31 3.14e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs78456975 1.000 rs6730391 chr2:1566838 A/C cg12573674 chr2:1569213 NA -0.51 -9.7 -0.36 7.42e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2153535 0.601 rs9328487 chr6:8529378 G/C cg21535247 chr6:8435926 SLC35B3 0.39 8.78 0.33 1.48e-17 Motion sickness; BRCA cis rs9649213 0.593 rs7787858 chr7:98009914 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.55 -0.32 9.39e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs7980799 0.682 rs4931719 chr12:33602986 G/A cg26384229 chr12:38710491 ALG10B -0.52 -10.99 -0.4 7.56e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2882667 0.554 rs1368425 chr5:138280217 A/G cg04439458 chr5:138467593 SIL1 -0.32 -8.07 -0.3 3.56e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3768617 0.706 rs11588675 chr1:182988052 C/T ch.1.3577855R chr1:183094577 LAMC1 0.48 11.16 0.4 1.52e-26 Fuchs's corneal dystrophy; BRCA cis rs6750795 0.502 rs11685196 chr2:232381298 A/G cg19187155 chr2:232395269 NMUR1 0.59 13.67 0.48 1.7e-37 Height; BRCA cis rs4819052 0.851 rs4819046 chr21:46664955 C/T cg06618935 chr21:46677482 NA -0.36 -7.86 -0.3 1.6e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7586879 1.000 rs11683212 chr2:25120196 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.33 0.35 1.68e-19 Body mass index; BRCA cis rs1577917 1.000 rs34581302 chr6:86705948 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.37 -0.47 4.17e-36 Response to antipsychotic treatment; BRCA cis rs1005277 0.579 rs1740745 chr10:38520056 T/C cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.61e-27 Extrinsic epigenetic age acceleration; BRCA trans rs1005277 0.563 rs2800550 chr10:38482929 T/C cg17830980 chr10:43048298 ZNF37B -0.56 -13.68 -0.48 1.47e-37 Extrinsic epigenetic age acceleration; BRCA cis rs8114671 0.967 rs6088747 chr20:33754604 G/T cg07148914 chr20:33460835 GGT7 0.39 8.29 0.31 6.8e-16 Height; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg18765753 chr7:1198926 ZFAND2A -0.47 -10.66 -0.39 1.52e-24 Longevity;Endometriosis; BRCA cis rs35306767 0.715 rs12777801 chr10:1036285 T/A cg18964960 chr10:1102726 WDR37 0.61 8.22 0.31 1.1e-15 Eosinophil percentage of granulocytes; BRCA cis rs1113500 0.933 rs10785833 chr1:108639082 A/G cg06207961 chr1:108661230 NA 0.45 10.95 0.4 1.11e-25 Growth-regulated protein alpha levels; BRCA cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg27129171 chr3:47204927 SETD2 0.74 18.61 0.59 4.14e-62 Colorectal cancer; BRCA trans rs11039798 1.000 rs11039904 chr11:48682597 T/A cg15704280 chr7:45808275 SEPT13 0.6 8.83 0.33 1.02e-17 Axial length; BRCA trans rs17685 0.753 rs2286830 chr7:75693963 C/T cg19862616 chr7:65841803 NCRNA00174 -0.86 -28.72 -0.75 3.81e-117 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg00677455 chr12:58241039 CTDSP2 0.47 11.56 0.42 3.43e-28 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.897 rs1984022 chr21:40596085 G/A cg11644478 chr21:40555479 PSMG1 0.85 19.42 0.61 2.19e-66 Cognitive function; BRCA cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg01028140 chr2:1542097 TPO -0.56 -11.48 -0.41 7.52e-28 IgG glycosylation; BRCA cis rs868036 1.000 rs884202 chr15:68054388 G/A cg08079166 chr15:68083412 MAP2K5 -0.33 -8.71 -0.33 2.52e-17 Restless legs syndrome; BRCA trans rs783540 0.934 rs10400906 chr15:83297138 A/G cg18393722 chr15:85113863 UBE2QP1 0.28 8.77 0.33 1.57e-17 Schizophrenia; BRCA cis rs57590327 0.528 rs2229519 chr3:81698130 T/C cg07356753 chr3:81810745 GBE1 -0.42 -9.72 -0.36 6.32e-21 Extraversion; BRCA cis rs7582180 0.676 rs6542940 chr2:100982144 A/T cg14675211 chr2:100938903 LONRF2 0.41 9.2 0.34 4.82e-19 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs4712959 chr6:25727057 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs12618769 0.625 rs17034241 chr2:99224998 C/G cg10123293 chr2:99228465 UNC50 0.43 8.6 0.32 6.35e-17 Bipolar disorder; BRCA cis rs12142240 0.698 rs72677594 chr1:46824371 A/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA trans rs2270927 0.510 rs31244 chr5:75594743 G/A cg13563193 chr19:33072644 PDCD5 0.87 10.38 0.38 2.0500000000000001e-23 Mean corpuscular volume; BRCA cis rs1707322 0.682 rs10890334 chr1:46100378 A/T cg06784218 chr1:46089804 CCDC17 0.51 12.25 0.44 3.85e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs561341 1.000 rs508192 chr17:30315147 C/T cg27661571 chr11:113659931 NA 0.66 10.44 0.38 1.19e-23 Hip circumference adjusted for BMI; BRCA cis rs3796619 1.000 rs4974601 chr4:1095410 G/A cg27284194 chr4:1044797 NA 0.43 9.26 0.34 3.13e-19 Recombination rate (males); BRCA cis rs1881797 1.000 rs66845073 chr1:247688010 C/T cg05639522 chr1:247681581 NA 0.47 10.61 0.39 2.39e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs921968 0.509 rs655441 chr2:219357545 C/T cg10223061 chr2:219282414 VIL1 -0.27 -7.92 -0.3 1.04e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs1595825 0.732 rs7577835 chr2:198378056 T/C cg19156104 chr2:198669113 PLCL1 -0.47 -8.27 -0.31 7.54e-16 Ulcerative colitis; BRCA cis rs7833790 1.000 rs7460277 chr8:82709777 T/C cg02079420 chr8:82753780 SNX16 0.35 7.91 0.3 1.12e-14 Diastolic blood pressure; BRCA cis rs1707322 1.000 rs11211200 chr1:46288352 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.8 0.39 4.2e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1372520 0.873 rs2737026 chr4:90779823 A/G cg15133208 chr4:90757351 SNCA -0.4 -8.3 -0.31 6e-16 Neuroticism; BRCA cis rs2832077 0.883 rs11702413 chr21:30188395 A/C cg08807101 chr21:30365312 RNF160 -0.46 -7.89 -0.3 1.3e-14 Cognitive test performance; BRCA cis rs9467711 0.591 rs13195692 chr6:26044373 C/T cg21479132 chr6:26055353 NA 0.58 8.16 0.31 1.77e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs6545883 0.929 rs12617911 chr2:61740825 A/G cg15711740 chr2:61764176 XPO1 -0.55 -14.13 -0.49 1.18e-39 Tuberculosis; BRCA cis rs875971 0.929 rs4122249 chr7:65920936 T/C cg11764359 chr7:65958608 NA 0.78 18.69 0.59 1.55e-62 Aortic root size; BRCA cis rs11874712 1.000 rs1800639 chr18:43671240 G/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.35 8.24 0.31 9.99e-16 Migraine - clinic-based; BRCA cis rs6088580 0.524 rs6087616 chr20:33263033 T/C cg08999081 chr20:33150536 PIGU -0.33 -8.47 -0.32 1.72e-16 Glomerular filtration rate (creatinine); BRCA cis rs875971 0.862 rs778686 chr7:65835910 C/T cg18876405 chr7:65276391 NA 0.51 11.57 0.42 2.98e-28 Aortic root size; BRCA cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg26597838 chr10:835615 NA 0.87 15.6 0.53 9.49e-47 Eosinophil percentage of granulocytes; BRCA trans rs6952808 0.582 rs871925 chr7:2047875 G/A cg04565464 chr8:145669602 NFKBIL2 -0.35 -8.82 -0.33 1.07e-17 Bipolar disorder and schizophrenia; BRCA cis rs13095912 1.000 rs7374856 chr3:185311964 A/C cg11274856 chr3:185301563 NA 0.34 8.53 0.32 1.1e-16 Systolic blood pressure; BRCA cis rs2749592 0.550 rs7917262 chr10:37874602 A/C cg25427524 chr10:38739819 LOC399744 0.59 13.44 0.47 1.85e-36 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7552404 1.000 rs7533888 chr1:76160449 A/C cg10523679 chr1:76189770 ACADM 0.76 15.91 0.53 2.83e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9814567 1.000 rs6763088 chr3:134254989 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7833986 0.501 rs2719227 chr8:57043794 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.63 -11.58 -0.42 2.89e-28 Height; BRCA cis rs875971 0.862 rs12698526 chr7:65969105 T/C cg11764359 chr7:65958608 NA 0.74 16.46 0.55 4.94e-51 Aortic root size; BRCA cis rs2046867 0.862 rs75638790 chr3:72830502 C/T cg25664220 chr3:72788482 NA -0.55 -11.41 -0.41 1.49e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs6754311 0.731 rs309134 chr2:136755684 A/G cg07169764 chr2:136633963 MCM6 -0.72 -15.01 -0.51 7.75e-44 Mosquito bite size; BRCA cis rs875971 0.862 rs7786892 chr7:65628876 G/A cg18876405 chr7:65276391 NA -0.52 -11.77 -0.42 4.46e-29 Aortic root size; BRCA cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg11789530 chr4:8429930 ACOX3 -0.68 -17.65 -0.57 4.31e-57 Response to antineoplastic agents; BRCA cis rs1059312 0.932 rs11059916 chr12:129287609 C/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.28 9.19 0.34 5.37e-19 Systemic lupus erythematosus; BRCA cis rs911555 0.511 rs2296483 chr14:104029792 G/A cg12935359 chr14:103987150 CKB -0.54 -13.28 -0.46 1.07e-35 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.522 rs868833 chr7:1054973 C/G cg23978390 chr7:1156363 C7orf50 0.35 7.84 0.3 1.9e-14 Bronchopulmonary dysplasia; BRCA trans rs1814175 0.527 rs7128827 chr11:49665644 C/T cg11707556 chr5:10655725 ANKRD33B 0.47 10.63 0.39 1.99e-24 Height; BRCA cis rs72766638 0.806 rs56303154 chr9:136936376 C/T cg13789015 chr9:136890014 NCRNA00094 0.55 8.78 0.33 1.49e-17 Mosquito bite size; BRCA cis rs910316 0.726 rs175040 chr14:75469555 A/G cg08847533 chr14:75593920 NEK9 -0.84 -20.9 -0.64 2.6e-74 Height; BRCA cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg23248424 chr5:179741104 GFPT2 -0.67 -14.31 -0.49 1.68e-40 Height; BRCA cis rs13191362 0.507 rs7772787 chr6:163190981 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.4 7.86 0.3 1.66e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs939658 0.776 rs35904425 chr15:79444567 G/A cg17916960 chr15:79447300 NA -0.46 -11.45 -0.41 9.24e-28 Refractive error; BRCA cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.94 -0.37 9.65e-22 Alzheimer's disease (late onset); BRCA cis rs11718455 0.960 rs35666538 chr3:44004826 A/G cg08738300 chr3:44038990 NA 0.45 8.78 0.33 1.47e-17 Coronary artery disease; BRCA cis rs7737355 0.947 rs2108869 chr5:131086880 A/G cg06307176 chr5:131281290 NA 0.52 10.07 0.37 2.99e-22 Life satisfaction; BRCA cis rs2625529 0.938 rs9120 chr15:72115763 G/A cg16672083 chr15:72433130 SENP8 -0.81 -16.62 -0.55 8.55e-52 Red blood cell count; BRCA cis rs6088590 0.561 rs6087600 chr20:33157217 T/C cg24642439 chr20:33292090 TP53INP2 0.56 12.4 0.44 8.36e-32 Coronary artery disease; BRCA cis rs6545883 0.562 rs777588 chr2:61426820 G/A cg15711740 chr2:61764176 XPO1 -0.47 -11.83 -0.42 2.56e-29 Tuberculosis; BRCA trans rs12517041 1.000 rs12514453 chr5:23289951 A/C ch.8.1293020R chr8:59333349 UBXN2B 0.45 8.16 0.31 1.78e-15 Calcium levels; BRCA cis rs10193935 0.582 rs13394853 chr2:42630900 T/C cg27598129 chr2:42591480 NA -0.79 -13.41 -0.47 2.69e-36 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.837 rs12370891 chr12:37984531 A/G cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.31e-21 Bladder cancer; BRCA cis rs281408 0.559 rs281381 chr19:49214748 C/T cg13540341 chr19:49222985 MAMSTR -0.38 -10.02 -0.37 4.9e-22 Urinary metabolites (H-NMR features); BRCA cis rs2836974 0.931 rs13625 chr21:40669083 G/T cg17971929 chr21:40555470 PSMG1 0.77 17.64 0.57 4.64e-57 Cognitive function; BRCA cis rs9486719 0.948 rs2092095 chr6:96870864 T/G cg06623918 chr6:96969491 KIAA0776 0.73 12.9 0.45 5.51e-34 Migraine;Coronary artery disease; BRCA cis rs6582630 0.537 rs2204006 chr12:38407098 A/G cg13010199 chr12:38710504 ALG10B 0.45 9.34 0.35 1.53e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs11098499 0.863 rs3822192 chr4:120445720 A/C cg09307838 chr4:120376055 NA 0.68 13.41 0.47 2.68e-36 Corneal astigmatism; BRCA cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg10802521 chr3:52805072 NEK4 0.33 8.86 0.33 8.06e-18 Bipolar disorder; BRCA cis rs4665809 0.525 rs10865402 chr2:26535383 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.51 -10.33 -0.38 3.16e-23 Gut microbiome composition (summer); BRCA cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg06697600 chr4:7070879 GRPEL1 -0.53 -10.84 -0.39 2.93e-25 Monocyte percentage of white cells; BRCA cis rs7385804 0.796 rs10277087 chr7:100307538 C/G cg16850897 chr7:100343110 ZAN 0.37 8.44 0.32 2.14e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs10504229 1.000 rs112272435 chr8:58170371 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs7766436 0.885 rs1418312 chr6:22589704 C/T cg13666174 chr6:22585274 NA -0.49 -11.55 -0.42 3.57e-28 Coronary artery disease; BRCA cis rs2760061 0.598 rs658238 chr1:228121291 A/G cg02753203 chr1:228287806 NA -0.58 -12.38 -0.44 1.04e-31 Diastolic blood pressure; BRCA cis rs7312933 1.000 rs12372623 chr12:42531666 G/A cg01256987 chr12:42539512 GXYLT1 -0.56 -11.5 -0.41 5.81e-28 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs4363385 0.818 rs10888526 chr1:153000311 G/T cg24667326 chr1:152973720 SPRR3 -0.32 -8.58 -0.32 7.18e-17 Inflammatory skin disease; BRCA cis rs11718455 0.883 rs2372579 chr3:44034003 A/T cg08738300 chr3:44038990 NA 0.47 8.92 0.33 4.97e-18 Coronary artery disease; BRCA cis rs2115630 0.967 rs10438428 chr15:85330745 C/T cg12863693 chr15:85201151 NMB -0.36 -8.54 -0.32 9.87e-17 P wave terminal force; BRCA cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.15 -0.49 9.24e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9443645 0.901 rs56057971 chr6:79607182 G/A cg18132916 chr6:79620363 NA -0.43 -9.75 -0.36 4.99e-21 Intelligence (multi-trait analysis); BRCA cis rs13191362 0.507 rs2846519 chr6:163045463 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.49 -9.49 -0.35 4.31e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3857536 0.740 rs9342532 chr6:66886297 T/C cg07460842 chr6:66804631 NA -0.48 -9.27 -0.34 2.78e-19 Blood trace element (Cu levels); BRCA cis rs1113500 0.862 rs2336128 chr1:108640739 G/T cg06207961 chr1:108661230 NA 0.45 10.98 0.4 8.47e-26 Growth-regulated protein alpha levels; BRCA trans rs12517041 1.000 rs6859293 chr5:23312935 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.27 -0.31 7.52e-16 Calcium levels; BRCA cis rs6977660 0.714 rs6943204 chr7:19818671 A/G cg05791153 chr7:19748676 TWISTNB 0.48 9.42 0.35 7.97e-20 Thyroid stimulating hormone; BRCA cis rs1153858 1.000 rs12594857 chr15:45667178 A/G cg21132104 chr15:45694354 SPATA5L1 0.75 17.08 0.56 3.89e-54 Homoarginine levels; BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg18230493 chr5:56204884 C5orf35 -0.73 -14.29 -0.49 2.21e-40 Initial pursuit acceleration; BRCA cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.97 0.3 7.24e-15 Melanoma; BRCA cis rs1891275 0.515 rs2421694 chr10:93516104 A/G cg07889827 chr10:93443413 NA -0.41 -11.24 -0.41 7.05e-27 Intelligence (multi-trait analysis); BRCA cis rs11603020 0.851 rs10896631 chr11:57381263 T/C cg19752551 chr11:57585705 CTNND1 -0.42 -9.63 -0.36 1.41e-20 Blood protein levels; BRCA cis rs7493 0.901 rs2237586 chr7:95051052 G/T cg17330251 chr7:94953956 PON1 -0.42 -8.64 -0.32 4.63e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6964587 1.000 rs17164275 chr7:91590408 A/G cg17063962 chr7:91808500 NA 0.52 12.14 0.43 1.15e-30 Breast cancer; BRCA cis rs4808199 0.895 rs10419672 chr19:19471241 T/C cg03709012 chr19:19516395 GATAD2A 0.91 17.32 0.57 2.19e-55 Nonalcoholic fatty liver disease; BRCA cis rs35306767 0.855 rs2050944 chr10:918910 T/C cg26597838 chr10:835615 NA 1.02 17.81 0.58 6.22e-58 Eosinophil percentage of granulocytes; BRCA cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg16405210 chr4:1374714 KIAA1530 -0.58 -14.02 -0.49 3.93e-39 Longevity; BRCA cis rs4268898 0.931 rs2551121 chr2:24539967 T/C cg06627628 chr2:24431161 ITSN2 -0.51 -10.39 -0.38 1.86e-23 Asthma; BRCA cis rs7677751 0.806 rs1800810 chr4:55094031 C/G cg17187183 chr4:55093834 PDGFRA 0.44 9.27 0.34 2.73e-19 Corneal astigmatism; BRCA cis rs908922 0.676 rs7547628 chr1:152527738 T/C cg20991723 chr1:152506922 NA 0.37 8.3 0.31 6.04e-16 Hair morphology; BRCA cis rs523522 0.962 rs4767905 chr12:120930835 C/T cg12219531 chr12:120966889 COQ5 0.55 11.42 0.41 1.25e-27 High light scatter reticulocyte count; BRCA cis rs2795502 1.000 rs2744092 chr10:43339343 T/C cg20628663 chr10:43360327 NA -0.7 -13.62 -0.47 2.75e-37 Blood protein levels; BRCA cis rs9462027 0.628 rs28675115 chr6:34732514 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.96 -0.3 7.8e-15 Systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs17027225 chr4:99028564 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.89 0.4 1.85e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9486719 1.000 rs12212614 chr6:97036466 T/G cg06623918 chr6:96969491 KIAA0776 -0.76 -13.44 -0.47 1.88e-36 Migraine;Coronary artery disease; BRCA cis rs4268898 0.697 rs10445892 chr2:24406958 T/C cg26838691 chr2:24397539 C2orf84 0.39 7.84 0.3 1.85e-14 Asthma; BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg22920501 chr2:26401640 FAM59B -0.63 -11.21 -0.41 9.3e-27 Gut microbiome composition (summer); BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg08742575 chr21:47604166 C21orf56 0.41 7.91 0.3 1.15e-14 Testicular germ cell tumor; BRCA cis rs67311347 1.000 rs6599094 chr3:40399593 A/G cg09455208 chr3:40491958 NA 0.36 8.67 0.32 3.61e-17 Renal cell carcinoma; BRCA cis rs9814567 0.964 rs12492930 chr3:134222722 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6089584 0.821 rs4925332 chr20:60604639 C/T cg13770153 chr20:60521292 NA -0.43 -9.46 -0.35 5.93e-20 Body mass index; BRCA cis rs796364 0.806 rs10931889 chr2:201101900 G/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.57 -8.26 -0.31 8.65e-16 Schizophrenia; BRCA cis rs59043219 1 rs59043219 chr1:209970610 G/A cg22442454 chr1:209979470 IRF6 0.42 10.99 0.4 7.4e-26 Crohn's disease;Inflammatory bowel disease;Alzheimer's disease (APOE e4 interaction); BRCA cis rs17376456 0.877 rs10476526 chr5:93461916 G/A cg21475434 chr5:93447410 FAM172A 0.68 9.19 0.34 5.41e-19 Diabetic retinopathy; BRCA cis rs12367572 0.620 rs1857924 chr12:45344212 T/G cg04608330 chr12:45269318 NELL2 -0.4 -8.53 -0.32 1.08e-16 Gut microbiome composition (summer); BRCA cis rs752010 0.695 rs12123834 chr1:42105727 T/C cg06885757 chr1:42089581 HIVEP3 0.23 8.35 0.31 4.36e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs4363385 0.818 rs419721 chr1:153006902 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg21475434 chr5:93447410 FAM172A 0.7 8.9 0.33 5.82e-18 Diabetic retinopathy; BRCA cis rs7772486 0.790 rs7753833 chr6:146161432 C/A cg23711669 chr6:146136114 FBXO30 0.72 17.48 0.57 3.15e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs4718428 0.705 rs11028 chr7:66276217 T/C cg18252515 chr7:66147081 NA -0.51 -10.5 -0.38 6.87e-24 Corneal structure; BRCA cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.4 0.66 1.74e-82 Chronic sinus infection; BRCA cis rs7178424 0.711 rs11635569 chr15:62213597 G/A cg00456672 chr15:62358751 C2CD4A -0.39 -9.29 -0.34 2.39e-19 Height; BRCA cis rs66530629 0.958 rs4024244 chr1:25050228 G/A cg01905478 chr1:25040257 NA 0.36 8.28 0.31 7.13e-16 Plateletcrit; BRCA cis rs6450176 0.585 rs255761 chr5:53321956 G/T ch.5.1024479R chr5:53302184 ARL15 -0.52 -10.98 -0.4 8.15e-26 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9815354 1.000 rs9824731 chr3:41889698 G/T cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA trans rs9291683 0.530 rs11723970 chr4:9980462 T/C cg26043149 chr18:55253948 FECH 0.39 8.8 0.33 1.28e-17 Bone mineral density; BRCA cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 0.627 rs13014338 chr2:26463024 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.07 23.75 0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs4665809 0.878 rs6720312 chr2:26364934 A/G cg04944784 chr2:26401820 FAM59B 0.76 12.37 0.44 1.18e-31 Gut microbiome composition (summer); BRCA cis rs116095464 0.558 rs9687621 chr5:229194 C/T cg22857025 chr5:266934 NA -1.02 -19.96 -0.62 3.08e-69 Breast cancer; BRCA trans rs3733585 0.638 rs6414766 chr4:9956474 G/A cg26043149 chr18:55253948 FECH -0.38 -8.3 -0.31 6.1e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.716 rs6827474 chr4:99089683 T/G cg05340658 chr4:99064831 C4orf37 0.64 14.85 0.51 4.59e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6763687 0.725 rs7615743 chr3:171799045 G/C cg16233210 chr3:171778391 FNDC3B 0.37 8.15 0.31 1.91e-15 Red cell distribution width; BRCA cis rs36051895 0.659 rs7046077 chr9:5045328 C/G cg02405213 chr9:5042618 JAK2 -0.5 -9.65 -0.36 1.2e-20 Pediatric autoimmune diseases; BRCA cis rs10911363 0.592 rs2761581 chr1:183474850 G/C cg09173681 chr1:183549694 NCF2 0.54 11.29 0.41 4.49e-27 Systemic lupus erythematosus; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg25036284 chr2:26402008 FAM59B -0.93 -14.35 -0.49 1.11e-40 Gut microbiome composition (summer); BRCA cis rs7523273 0.597 rs2761437 chr1:207923081 A/G cg22525895 chr1:207977042 MIR29B2 0.41 8.59 0.32 6.82e-17 Schizophrenia; BRCA trans rs2204008 0.743 rs11182052 chr12:38450421 T/C cg06521331 chr12:34319734 NA -0.45 -8.6 -0.32 6.09e-17 Bladder cancer; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg00166722 chr3:10149974 C3orf24 0.65 12.78 0.45 1.82e-33 Alzheimer's disease; BRCA cis rs2635047 0.967 rs2668786 chr18:44708472 A/G cg19077165 chr18:44547161 KATNAL2 -0.37 -7.97 -0.3 7.06e-15 Educational attainment; BRCA cis rs1577917 1.000 rs13194429 chr6:86646705 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.19 -0.46 2.56e-35 Response to antipsychotic treatment; BRCA cis rs2842992 0.830 rs1998365 chr6:160179535 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.71 0.45 3.85e-33 Age-related macular degeneration (geographic atrophy); BRCA cis rs9394841 0.692 rs3806113 chr6:41876335 C/T cg08135965 chr6:41755394 TOMM6 0.51 8.65 0.32 4.14e-17 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs739401 0.595 rs6578304 chr11:2998279 A/G cg25174290 chr11:3078921 CARS -0.35 -10.19 -0.37 1.1e-22 Longevity; BRCA cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg07148914 chr20:33460835 GGT7 0.38 8.57 0.32 7.57e-17 Height; BRCA cis rs2576037 0.583 rs8096263 chr18:44515216 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.45 -9.37 -0.35 1.24e-19 Personality dimensions; BRCA cis rs7568498 0.564 rs9287807 chr2:161915361 T/C cg08807892 chr2:162101083 NA -0.46 -8.15 -0.31 1.94e-15 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy); BRCA cis rs7617773 0.817 rs9837228 chr3:48324466 A/T cg11946769 chr3:48343235 NME6 -0.63 -13.84 -0.48 2.83e-38 Coronary artery disease; BRCA cis rs11098499 0.954 rs1546505 chr4:120241224 A/G cg09307838 chr4:120376055 NA 0.68 14.34 0.49 1.23e-40 Corneal astigmatism; BRCA cis rs514406 0.929 rs555741 chr1:53318851 T/G cg24675658 chr1:53192096 ZYG11B -0.51 -11.25 -0.41 6.58e-27 Monocyte count; BRCA cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg03425785 chr20:62221387 GMEB2 0.53 8.58 0.32 7.01e-17 Glioblastoma; BRCA cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.47 -10.15 -0.37 1.47e-22 Multiple sclerosis; BRCA cis rs12701220 0.604 rs34904312 chr7:1135883 G/A cg23978390 chr7:1156363 C7orf50 0.4 7.95 0.3 8.36e-15 Bronchopulmonary dysplasia; BRCA cis rs6831352 0.918 rs28987097 chr4:100049579 C/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg04025307 chr7:1156635 C7orf50 0.46 10.24 0.38 6.86e-23 Longevity;Endometriosis; BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg13047869 chr3:10149882 C3orf24 0.57 10.33 0.38 3.02e-23 Alzheimer's disease; BRCA cis rs9487051 0.773 rs351749 chr6:109533353 A/T cg21918786 chr6:109611834 NA -0.34 -8.99 -0.34 2.7e-18 Reticulocyte fraction of red cells; BRCA cis rs7772486 0.681 rs9390343 chr6:146010527 A/T cg23711669 chr6:146136114 FBXO30 -0.68 -15.95 -0.53 1.83e-48 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.588 rs3756236 chr4:10013463 T/A cg00071950 chr4:10020882 SLC2A9 0.67 16.82 0.55 7.99e-53 Bone mineral density; BRCA cis rs2624839 0.704 rs2624833 chr3:50212512 G/T cg24110177 chr3:50126178 RBM5 -0.47 -11.89 -0.43 1.33e-29 Intelligence (multi-trait analysis); BRCA cis rs13102973 1.000 rs7439938 chr4:135897696 G/A cg14419869 chr4:135874104 NA -0.56 -11.95 -0.43 7.24e-30 Subjective well-being; BRCA cis rs7103648 0.897 rs35032070 chr11:47408592 G/A cg20307385 chr11:47447363 PSMC3 0.82 20.88 0.64 3.43e-74 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs8103278 0.864 rs2070737 chr19:46282890 A/T cg12641515 chr19:46296257 DMWD -0.57 -12.7 -0.45 4.18e-33 Coronary artery disease; BRCA cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg18225595 chr11:63971243 STIP1 0.56 13.54 0.47 6.93e-37 Platelet count; BRCA cis rs10870270 0.956 rs11146325 chr10:133767529 A/G cg08754478 chr10:133766260 PPP2R2D -0.68 -14.1 -0.49 1.71e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs6743226 0.840 rs10933549 chr2:242240702 A/G cg10021735 chr2:242295487 FARP2 0.37 10.26 0.38 5.55e-23 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs1577917 0.883 rs1415749 chr6:86779084 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.33 8.63 0.32 4.75e-17 Response to antipsychotic treatment; BRCA trans rs61931739 0.534 rs11052973 chr12:34029708 A/G cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.87e-20 Morning vs. evening chronotype; BRCA cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg10802521 chr3:52805072 NEK4 -0.32 -8.12 -0.31 2.44e-15 Bipolar disorder; BRCA cis rs2153535 0.584 rs55945625 chr6:8371367 C/T cg07606381 chr6:8435919 SLC35B3 -0.57 -12.19 -0.43 7.19e-31 Motion sickness; BRCA cis rs490234 0.702 rs4838274 chr9:128345994 C/A cg14078157 chr9:128172775 NA -0.51 -11.33 -0.41 2.97e-27 Mean arterial pressure; BRCA cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.57 8.09 0.3 3.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.604 rs2389887 chr4:120570644 T/C cg25214090 chr10:38739885 LOC399744 0.52 10.95 0.4 1.08e-25 Corneal astigmatism; BRCA cis rs6748734 1.000 rs4675863 chr2:241830763 A/T cg07537917 chr2:241836409 C2orf54 -0.49 -11.74 -0.42 5.86e-29 Urinary metabolites; BRCA cis rs1577917 0.958 rs11755642 chr6:86450066 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.55 -14.34 -0.49 1.3e-40 Response to antipsychotic treatment; BRCA cis rs10752881 1.000 rs10797810 chr1:182980950 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.53e-53 Colorectal cancer; BRCA cis rs28735056 0.563 rs55642704 chr18:77688124 C/T cg20368463 chr18:77673604 PQLC1 -0.52 -12.66 -0.45 6.1e-33 Schizophrenia; BRCA cis rs35306767 0.903 rs12769002 chr10:927666 C/G cg26597838 chr10:835615 NA -1.27 -21.21 -0.64 5.42e-76 Eosinophil percentage of granulocytes; BRCA trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg17470723 chr8:74884337 TCEB1 0.4 8.62 0.32 5.44e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1008375 0.966 rs3775924 chr4:17585984 T/C cg16339924 chr4:17578868 LAP3 0.66 16.94 0.56 2.01e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4563143 0.675 rs112383987 chr19:29261081 C/T cg03161606 chr19:29218774 NA 0.46 8.14 0.31 2.04e-15 Methadone dose in opioid dependence; BRCA cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg08027265 chr7:2291960 NA -0.35 -8.26 -0.31 8.3e-16 Bipolar disorder and schizophrenia; BRCA cis rs9815354 1.000 rs13325965 chr3:41914942 G/T cg03022575 chr3:42003672 ULK4 0.51 8.15 0.31 1.91e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs11758351 1.000 rs16891405 chr6:26204506 A/G cg01420254 chr6:26195488 NA 0.55 8.54 0.32 9.6e-17 Gout;Renal underexcretion gout; BRCA cis rs66887589 0.807 rs7694483 chr4:120405929 T/A cg09307838 chr4:120376055 NA 0.44 9.05 0.34 1.68e-18 Diastolic blood pressure; BRCA cis rs2439831 0.702 rs16977724 chr15:44151299 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.79 12.92 0.46 4.2e-34 Lung cancer in ever smokers; BRCA cis rs2153535 0.580 rs9328486 chr6:8528008 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.59e-19 Motion sickness; BRCA cis rs875971 0.545 rs801199 chr7:66025273 A/G cg11764359 chr7:65958608 NA -0.65 -11.56 -0.42 3.42e-28 Aortic root size; BRCA cis rs4466137 1.000 rs1154888 chr5:82977410 C/A cg16102102 chr5:83017553 HAPLN1 -0.91 -17.9 -0.58 2.08e-58 Prostate cancer; BRCA cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg03264133 chr6:25882463 NA -0.4 -9.04 -0.34 1.86e-18 Height; BRCA trans rs853679 0.607 rs36101351 chr6:27943369 C/T cg01620082 chr3:125678407 NA -0.98 -11.11 -0.4 2.38e-26 Depression; BRCA cis rs2806561 0.514 rs7519093 chr1:23541078 A/T cg19743168 chr1:23544995 NA -0.66 -16.62 -0.55 7.97e-52 Height; BRCA cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg01579765 chr21:45077557 HSF2BP -0.43 -11.45 -0.41 1e-27 Mean corpuscular volume; BRCA cis rs4509693 0.882 rs7911997 chr10:102492380 A/G cg24179445 chr10:102496915 NA 0.37 9.1 0.34 1.1e-18 Alzheimer's disease; BRCA cis rs9921192 0.967 rs3747571 chr16:4323983 A/G cg00021532 chr16:4324280 TFAP4 0.58 15.78 0.53 1.25e-47 Prostate-specific antigen levels; BRCA trans rs4714291 0.928 rs761799 chr6:39990050 T/A cg02267698 chr19:7991119 CTXN1 0.4 7.93 0.3 1.01e-14 Strep throat; BRCA cis rs9368481 0.554 rs2754603 chr6:26965139 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.35 -12.81 -0.45 1.34e-33 Autism spectrum disorder or schizophrenia; BRCA cis rs10949834 0.529 rs7785826 chr7:73548785 C/A cg07137043 chr7:73588983 EIF4H -0.62 -9.28 -0.34 2.59e-19 Verbal memory performance (residualized delayed recall change); BRCA cis rs2859741 1.000 rs2859741 chr1:37509352 C/T cg09363841 chr1:37513479 NA -0.65 -16.06 -0.54 5.1e-49 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs10751667 0.643 rs10902238 chr11:944810 G/A ch.11.42038R chr11:967971 AP2A2 0.5 15.86 0.53 5.38e-48 Alzheimer's disease (late onset); BRCA cis rs7666738 0.546 rs17546687 chr4:98769266 T/A cg05340658 chr4:99064831 C4orf37 0.56 10.75 0.39 6.82e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs10022389 chr4:99022229 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2777491 1.000 rs2777491 chr15:41735710 T/G cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.03 -0.54 7.19e-49 Ulcerative colitis; BRCA cis rs867371 1.000 rs4778982 chr15:82475272 T/G cg00614314 chr15:82944287 LOC80154 0.43 9.09 0.34 1.21e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg11764359 chr7:65958608 NA 0.68 15.17 0.51 1.34e-44 Aortic root size; BRCA cis rs2019137 0.936 rs2305133 chr2:113956821 C/G cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.56 -11.06 -0.4 3.82e-26 Lymphocyte counts; BRCA trans rs11098499 0.954 rs6822679 chr4:120402702 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.03 0.3 4.79e-15 Corneal astigmatism; BRCA cis rs61990749 0.597 rs12887606 chr14:78200620 G/A cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.91 0.3 1.15e-14 Fibroblast growth factor basic levels; BRCA cis rs4820539 1.000 rs5759596 chr22:23475750 G/A cg14186256 chr22:23484241 RTDR1 0.8 25.19 0.71 8.7e-98 Bone mineral density; BRCA cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg21573476 chr21:45109991 RRP1B -0.4 -10.6 -0.39 2.63e-24 Mean corpuscular volume; BRCA cis rs9815354 0.812 rs77047799 chr3:41958895 T/C cg03022575 chr3:42003672 ULK4 0.68 9.67 0.36 9.71e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00166722 chr3:10149974 C3orf24 0.55 11.06 0.4 3.73e-26 Alzheimer's disease; BRCA cis rs2243480 1.000 rs4718269 chr7:65200778 C/G cg18252515 chr7:66147081 NA 0.87 12.48 0.44 3.79e-32 Diabetic kidney disease; BRCA cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.36 -0.44 1.32e-31 Tonsillectomy; BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg05457628 chr5:178986728 RUFY1 0.53 12.12 0.43 1.44e-30 Lung cancer; BRCA cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.38 -0.31 3.45e-16 Intelligence (multi-trait analysis); BRCA cis rs2731664 0.792 rs335432 chr5:176866258 G/A cg23176889 chr5:176863531 GRK6 -0.58 -15.25 -0.52 5.08e-45 Intelligence (multi-trait analysis); BRCA cis rs7666738 1.000 rs7666738 chr4:98968077 C/T cg07917127 chr4:99064746 C4orf37 0.43 8.02 0.3 5.05e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs11098499 0.863 rs6534141 chr4:120485223 A/T cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.13 0.31 2.29e-15 Corneal astigmatism; BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.43 -8.52 -0.32 1.14e-16 Tonsillectomy; BRCA trans rs7829975 0.806 rs2428 chr8:8641145 C/T cg21775007 chr8:11205619 TDH 0.38 8.42 0.32 2.43e-16 Mood instability; BRCA cis rs68170813 0.559 rs78440378 chr7:106962782 C/A cg02696742 chr7:106810147 HBP1 -0.53 -8.54 -0.32 1.01e-16 Coronary artery disease; BRCA cis rs7589728 0.563 rs2292868 chr2:88475047 A/G cg04511125 chr2:88470314 THNSL2 -0.93 -13.17 -0.46 3.1e-35 Plasma clusterin levels; BRCA cis rs10504229 0.683 rs72650839 chr8:58130029 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs12579753 0.917 rs71466033 chr12:82242187 C/T cg07988820 chr12:82153109 PPFIA2 -0.65 -10.48 -0.38 7.7e-24 Resting heart rate; BRCA cis rs10751667 0.666 rs6597962 chr11:976351 C/T cg01483505 chr11:975446 AP2A2 0.31 8.27 0.31 7.92e-16 Alzheimer's disease (late onset); BRCA cis rs3820928 0.874 rs55748731 chr2:227818629 C/A cg11843606 chr2:227700838 RHBDD1 -0.39 -8.66 -0.32 3.83e-17 Pulmonary function; BRCA cis rs425277 1.000 rs381664 chr1:2088104 A/G cg00981070 chr1:2046702 PRKCZ 0.31 8.22 0.31 1.14e-15 Height; BRCA cis rs11676348 0.846 rs13009946 chr2:219007752 A/C cg00012203 chr2:219082015 ARPC2 -0.43 -8.48 -0.32 1.57e-16 Ulcerative colitis; BRCA cis rs3767633 0.800 rs6685369 chr1:161754834 T/C cg09175582 chr1:161736000 ATF6 0.5 8.35 0.31 4.35e-16 IgG glycosylation; BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg22800045 chr5:56110881 MAP3K1 0.64 12.28 0.44 2.77e-31 Initial pursuit acceleration; BRCA cis rs7811142 0.830 rs73401451 chr7:99981895 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.22 -0.46 1.99e-35 Platelet count; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg10150615 chr22:24372951 LOC391322 0.42 9.16 0.34 6.8e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg10802521 chr3:52805072 NEK4 -0.33 -8.48 -0.32 1.61e-16 Bipolar disorder; BRCA cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg06108461 chr20:60628389 TAF4 -0.79 -17.09 -0.56 3.11e-54 Body mass index; BRCA cis rs9527 0.590 rs4917992 chr10:104786313 G/A cg04362960 chr10:104952993 NT5C2 0.43 9.87 0.36 1.81e-21 Arsenic metabolism; BRCA cis rs6582630 0.555 rs7969922 chr12:38529491 C/T cg13010199 chr12:38710504 ALG10B 0.52 10.86 0.39 2.58e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs965469 0.779 rs6037543 chr20:3289505 A/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.75 -0.33 1.85e-17 IFN-related cytopenia; BRCA cis rs11719291 0.833 rs11715835 chr3:48770732 C/T cg00383909 chr3:49044727 WDR6 0.96 15.77 0.53 1.48e-47 Cognitive function; BRCA trans rs6582630 0.555 rs7965311 chr12:38513307 G/A cg06521331 chr12:34319734 NA 0.46 9.28 0.34 2.58e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs9814567 0.964 rs6772406 chr3:134210183 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.1 -0.34 1.15e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9814567 0.896 rs6794258 chr3:134344505 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.83 -0.58 5.39e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6540559 1.000 rs4844895 chr1:209958580 T/C cg22029157 chr1:209979665 IRF6 0.56 12.59 0.45 1.26e-32 Cleft lip with or without cleft palate; BRCA trans rs6952808 0.723 rs60432611 chr7:2029629 G/C cg04565464 chr8:145669602 NFKBIL2 0.38 8.93 0.33 4.59e-18 Bipolar disorder and schizophrenia; BRCA cis rs6460942 0.778 rs76030612 chr7:12462937 C/A cg20607287 chr7:12443886 VWDE -0.51 -8.14 -0.31 2e-15 Coronary artery disease; BRCA cis rs7959452 0.640 rs4761154 chr12:69705362 A/G cg20891283 chr12:69753455 YEATS4 -0.58 -14.9 -0.51 2.62e-43 Blood protein levels; BRCA cis rs6750047 0.756 rs336038 chr2:38260750 C/G cg07380506 chr2:38303506 CYP1B1 0.42 9.48 0.35 5.07e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs2797160 0.967 rs1578793 chr6:126015057 A/G cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.2e-20 Endometrial cancer; BRCA cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg17063962 chr7:91808500 NA -0.54 -12.28 -0.44 2.75e-31 Breast cancer; BRCA cis rs1577917 1.000 rs12201571 chr6:86609750 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -13.07 -0.46 9.55e-35 Response to antipsychotic treatment; BRCA cis rs2882667 0.690 rs700619 chr5:138088749 G/C cg04439458 chr5:138467593 SIL1 0.33 8.15 0.31 1.95e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12612619 0.732 rs11680032 chr2:27198148 C/T cg00617064 chr2:27272375 NA -0.3 -8.09 -0.3 3.01e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7666738 1.000 rs1426673 chr4:98924024 G/A cg03676636 chr4:99064102 C4orf37 0.22 8.1 0.31 2.7e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11971779 0.588 rs6972408 chr7:139071474 T/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs739401 0.572 rs739399 chr11:3016452 A/G cg25174290 chr11:3078921 CARS 0.41 12.6 0.45 1.11e-32 Longevity; BRCA cis rs17711722 0.653 rs2460421 chr7:65491123 A/T cg11764359 chr7:65958608 NA -0.54 -11.09 -0.4 2.97e-26 Calcium levels; BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.38 -9.13 -0.34 8.88e-19 Tonsillectomy; BRCA cis rs1865760 1.000 rs56118523 chr6:25908975 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.27 0.41 5.3e-27 Height; BRCA cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg05283184 chr6:79620031 NA -0.43 -10.97 -0.4 9.31e-26 Intelligence (multi-trait analysis); BRCA cis rs7523050 0.643 rs12725689 chr1:109405151 T/C cg08274380 chr1:109419600 GPSM2 1.15 15.38 0.52 1.21e-45 Fat distribution (HIV); BRCA cis rs1005277 0.557 rs1854563 chr10:38434961 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.12e-26 Extrinsic epigenetic age acceleration; BRCA cis rs9640161 0.742 rs2159235 chr7:150017228 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.53 -13.41 -0.47 2.56e-36 Blood protein levels;Circulating chemerin levels; BRCA cis rs911186 0.740 rs6938200 chr6:27231150 A/G cg12292205 chr6:26970375 C6orf41 -0.6 -10.27 -0.38 5.36e-23 Autism spectrum disorder or schizophrenia; BRCA trans rs60843830 0.508 rs300750 chr2:208794 T/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.38 8.3 0.31 6.41e-16 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6546886 0.912 rs13006407 chr2:74280275 G/A cg14702570 chr2:74259524 NA -0.32 -8.13 -0.31 2.22e-15 Dialysis-related mortality; BRCA cis rs1865760 0.516 rs9358903 chr6:26061949 A/C cg17691542 chr6:26056736 HIST1H1C 0.53 11.37 0.41 2.14e-27 Height; BRCA cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg11833968 chr6:79620685 NA -0.4 -8.98 -0.33 2.92e-18 Intelligence (multi-trait analysis); BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg04025307 chr7:1156635 C7orf50 0.47 9.39 0.35 1e-19 Bronchopulmonary dysplasia; BRCA cis rs12530845 0.887 rs6948382 chr7:135323576 G/A cg23117316 chr7:135346802 PL-5283 -0.35 -8.13 -0.31 2.3e-15 Red blood cell traits; BRCA cis rs10504229 0.953 rs66509078 chr8:58174734 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 5.83e-21 Developmental language disorder (linguistic errors); BRCA cis rs13102973 0.640 rs13113331 chr4:135838729 C/T cg14419869 chr4:135874104 NA 0.45 9.09 0.34 1.24e-18 Subjective well-being; BRCA cis rs3096299 0.719 rs2911262 chr16:89515041 C/T cg00750074 chr16:89608354 SPG7 -0.4 -10.59 -0.39 3.02e-24 Multiple myeloma (IgH translocation); BRCA cis rs2637266 1.000 rs7478008 chr10:78355575 T/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs6484504 0.625 rs1535741 chr11:31375072 T/C cg26647111 chr11:31128758 NA 0.42 9.36 0.35 1.35e-19 Red blood cell count; BRCA cis rs3806843 0.900 rs2337984 chr5:140136811 G/A cg16179182 chr5:140090404 VTRNA1-1 0.43 9.78 0.36 3.76e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs3617 0.573 rs12492391 chr3:52912296 C/A cg11645453 chr3:52864694 ITIH4 0.34 8.54 0.32 9.97e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs9325144 0.560 rs2013804 chr12:38631079 C/T cg26384229 chr12:38710491 ALG10B -0.51 -13.21 -0.46 2.18e-35 Morning vs. evening chronotype; BRCA cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg17971929 chr21:40555470 PSMG1 -0.63 -14.16 -0.49 9.11e-40 Cognitive function; BRCA cis rs9880211 1.000 rs6768743 chr3:136205007 C/T cg21827317 chr3:136751795 NA 0.42 7.81 0.3 2.29e-14 Body mass index;Height; BRCA cis rs425277 0.606 rs262663 chr1:2084598 T/C cg24578937 chr1:2090814 PRKCZ 0.35 11.27 0.41 5.49e-27 Height; BRCA cis rs1865760 0.964 rs9295677 chr6:25933712 T/C cg16482183 chr6:26056742 HIST1H1C 0.51 10.33 0.38 3.11e-23 Height; BRCA cis rs1707322 0.650 rs4660879 chr1:46105401 C/A cg03146154 chr1:46216737 IPP 0.47 10.52 0.38 5.5e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7552404 0.731 rs11161836 chr1:76354333 C/T cg22875332 chr1:76189707 ACADM 0.65 11.83 0.42 2.55e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6088813 1.000 rs6141546 chr20:33949282 T/C cg14752227 chr20:34000481 UQCC -0.41 -8.77 -0.33 1.65e-17 Height; BRCA cis rs4481887 1.000 rs10888360 chr1:248479282 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.38 0.31 3.43e-16 Common traits (Other); BRCA cis rs7927771 0.524 rs7933896 chr11:47882782 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.46 0.35 5.68e-20 Subjective well-being; BRCA trans rs35110281 0.774 rs2838323 chr21:44999086 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.25 0.31 8.86e-16 Mean corpuscular volume; BRCA trans rs35110281 0.563 rs162371 chr21:44931489 G/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.11 0.31 2.62e-15 Mean corpuscular volume; BRCA cis rs11098499 0.754 rs1980025 chr4:120252806 A/G cg09307838 chr4:120376055 NA -0.62 -13.59 -0.47 3.92e-37 Corneal astigmatism; BRCA cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg16414030 chr3:133502952 NA -0.54 -12.32 -0.44 1.94e-31 Iron status biomarkers; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg04025307 chr7:1156635 C7orf50 0.59 9.46 0.35 5.6e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg03929089 chr4:120376271 NA 0.49 8.25 0.31 9e-16 Axial length; BRCA trans rs10506458 0.915 rs1009540 chr12:63414872 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.21 -19.55 -0.61 4.38e-67 Hemostatic factors and hematological phenotypes; BRCA cis rs763121 0.853 rs5757187 chr22:39021522 A/G cg14440974 chr22:39074834 NA 0.38 9.21 0.34 4.48e-19 Menopause (age at onset); BRCA cis rs1348850 0.558 rs4337505 chr2:178529714 A/T cg22681709 chr2:178499509 PDE11A -0.41 -8.93 -0.33 4.34e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs1973993 0.603 rs56827884 chr1:97021972 T/C cg10631902 chr5:14652156 NA -0.39 -9.73 -0.36 5.96e-21 Weight; BRCA cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs2131877 0.529 rs1009642 chr3:194857586 A/G cg13868855 chr3:194833887 C3orf21 0.36 8.74 0.33 2.1e-17 Non-small cell lung cancer; BRCA cis rs4862750 0.881 rs6813866 chr4:187872161 T/G cg03452623 chr4:187889614 NA -0.31 -10.25 -0.38 6.02e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.818 rs3806222 chr1:153002606 C/T cg24667326 chr1:152973720 SPRR3 -0.32 -8.81 -0.33 1.17e-17 Inflammatory skin disease; BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.98e-16 Menopause (age at onset); BRCA cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg06627557 chr7:32535165 LSM5;AVL9 1.06 30.03 0.77 3.03e-124 Cognitive ability; BRCA cis rs9517320 0.534 rs9554474 chr13:99140871 G/A cg07423050 chr13:99094983 FARP1 -0.48 -10.79 -0.39 4.71e-25 Longevity; BRCA cis rs6860806 0.631 rs7736284 chr5:131588151 T/C cg18301423 chr5:131593218 PDLIM4 0.33 8.55 0.32 8.88e-17 Breast cancer; BRCA cis rs2549003 1.000 rs2549002 chr5:131829578 C/A cg02551604 chr5:131831745 NA 0.41 15.82 0.53 8.2e-48 Asthma (sex interaction); BRCA cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg23711669 chr6:146136114 FBXO30 0.76 18.59 0.59 5.46e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs701145 0.617 rs9820619 chr3:154028294 G/T cg16511985 chr3:153974050 SGEF 0.44 9.84 0.36 2.27e-21 Coronary artery disease; BRCA cis rs7766436 0.885 rs4712698 chr6:22592807 C/T cg13666174 chr6:22585274 NA -0.49 -11.49 -0.41 6.42e-28 Coronary artery disease; BRCA cis rs12887734 0.546 rs4900597 chr14:104266664 A/G cg26031613 chr14:104095156 KLC1 0.52 9.36 0.35 1.37e-19 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9733 0.818 rs12403609 chr1:150676485 T/C cg18016565 chr1:150552671 MCL1 -0.41 -9.37 -0.35 1.19e-19 Tonsillectomy; BRCA trans rs236907 0.812 rs17657363 chr1:171801416 C/T cg13482142 chr2:234261155 NA -0.5 -8.28 -0.31 7.37e-16 Mean platelet volume; BRCA cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg01689657 chr7:91764605 CYP51A1 0.25 8.78 0.33 1.49e-17 Breast cancer; BRCA cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg00074818 chr8:8560427 CLDN23 0.39 8.39 0.32 3.1e-16 Obesity-related traits; BRCA cis rs3125734 0.719 rs4529854 chr10:64043975 C/T cg19640130 chr10:64028056 RTKN2 -0.29 -8.17 -0.31 1.63e-15 Rheumatoid arthritis; BRCA cis rs13191362 1.000 rs34177053 chr6:163007772 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.47 8.29 0.31 6.45e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11098499 0.645 rs72676059 chr4:120290828 C/G cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs7020830 0.858 rs13293465 chr9:37127678 C/T cg14294708 chr9:37120828 ZCCHC7 1.17 40.2 0.85 3.93e-177 Schizophrenia; BRCA cis rs3820928 0.804 rs4144327 chr2:227790262 C/T cg11843606 chr2:227700838 RHBDD1 -0.4 -8.9 -0.33 5.57e-18 Pulmonary function; BRCA cis rs10504229 1.000 rs112284078 chr8:58191640 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.28 -0.44 2.79e-31 Developmental language disorder (linguistic errors); BRCA cis rs4631830 0.683 rs11004409 chr10:51498019 G/C cg16070123 chr10:51489643 NA 0.35 7.85 0.3 1.73e-14 Prostate-specific antigen levels; BRCA cis rs4285028 0.948 rs79103597 chr3:121667629 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.8 -0.39 4.4e-25 Multiple sclerosis; BRCA cis rs847577 0.508 rs12538837 chr7:97684468 C/T cg24562669 chr7:97807699 LMTK2 0.39 8.9 0.33 5.76e-18 Breast cancer; BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg22903471 chr2:27725779 GCKR -0.37 -9.06 -0.34 1.61e-18 Total body bone mineral density; BRCA cis rs3733585 0.588 rs6449154 chr4:9956404 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.73e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2180341 1.000 rs6910763 chr6:127630925 T/C cg27446573 chr6:127587934 RNF146 0.9 21.49 0.65 1.64e-77 Breast cancer; BRCA cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg10802521 chr3:52805072 NEK4 -0.34 -9.29 -0.35 2.31e-19 Electroencephalogram traits; BRCA cis rs2625529 0.668 rs12914070 chr15:72334279 T/C cg16672083 chr15:72433130 SENP8 -0.84 -17.6 -0.57 8.19e-57 Red blood cell count; BRCA cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg08847533 chr14:75593920 NEK9 -0.79 -18.95 -0.6 7.17e-64 Height; BRCA cis rs6582630 0.593 rs7299329 chr12:38447943 G/C cg13010199 chr12:38710504 ALG10B 0.51 10.58 0.39 3.27e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg04025307 chr7:1156635 C7orf50 0.51 9.86 0.36 1.87e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs586533 0.881 rs590592 chr11:99506929 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.18 0.31 1.49e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs3925075 0.531 rs56392848 chr16:31360892 A/G cg02846316 chr16:31340340 ITGAM 0.42 8.59 0.32 6.47e-17 IgA nephropathy; BRCA cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg21573476 chr21:45109991 RRP1B -0.34 -8.89 -0.33 6.02e-18 Mean corpuscular volume; BRCA cis rs9527 0.545 rs12784384 chr10:104957594 G/C cg04362960 chr10:104952993 NT5C2 0.43 9.74 0.36 5.33e-21 Arsenic metabolism; BRCA cis rs10044254 0.587 rs4312881 chr5:15739807 T/G cg07238450 chr5:15720153 FBXL7 -0.38 -7.9 -0.3 1.19e-14 Asthma (corticosteroid response); BRCA cis rs7617773 0.780 rs4479622 chr3:48338173 C/T cg11946769 chr3:48343235 NME6 0.68 14.05 0.49 2.93e-39 Coronary artery disease; BRCA cis rs2235642 0.821 rs2281236 chr16:1603576 G/A cg26528668 chr16:1614120 IFT140 0.4 9.12 0.34 9.77e-19 Coronary artery disease; BRCA cis rs9394152 0.845 rs769051 chr6:33473894 T/G cg13560919 chr6:33536144 NA 0.62 12.65 0.45 6.6e-33 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 11.79 0.42 3.77e-29 Platelet count; BRCA cis rs6484504 0.652 rs485265 chr11:31407788 G/A cg26647111 chr11:31128758 NA 0.45 9.71 0.36 6.87e-21 Red blood cell count; BRCA cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg08213375 chr14:104286397 PPP1R13B 0.64 18.11 0.58 1.82e-59 Schizophrenia; BRCA cis rs11190604 0.767 rs10883491 chr10:102196071 G/T cg07080220 chr10:102295463 HIF1AN 0.44 9.61 0.36 1.65e-20 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.2 -0.31 1.28e-15 Prostate cancer; BRCA cis rs6952809 0.504 rs1978169 chr7:2434522 G/A cg23289794 chr7:2394357 EIF3B -0.46 -9.52 -0.35 3.38e-20 Multiple sclerosis; BRCA trans rs35110281 0.720 rs162380 chr21:44925283 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.44 -9.15 -0.34 7.82e-19 Mean corpuscular volume; BRCA cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg07917127 chr4:99064746 C4orf37 0.44 8.1 0.31 2.86e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 1.000 rs6956179 chr7:65806659 C/T cg12463550 chr7:65579703 CRCP -0.37 -8.16 -0.31 1.82e-15 Aortic root size; BRCA cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg26248373 chr2:1572462 NA -0.58 -13.04 -0.46 1.26e-34 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4862750 0.915 rs6835681 chr4:187903476 A/G cg10295955 chr4:187884368 NA -0.98 -31.37 -0.78 1.78e-131 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg13397359 chr6:42928475 GNMT 0.66 15.91 0.53 3.04e-48 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.61 11.77 0.42 4.22e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7312933 0.701 rs10880260 chr12:42561398 A/G cg01256987 chr12:42539512 GXYLT1 -0.46 -9.17 -0.34 6.47e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs36051895 0.554 rs10975027 chr9:5248827 G/A cg02405213 chr9:5042618 JAK2 -0.44 -7.88 -0.3 1.41e-14 Pediatric autoimmune diseases; BRCA cis rs6879260 1.000 rs1035411 chr5:179729519 A/G cg13944838 chr5:179740914 GFPT2 -0.7 -14.39 -0.49 6.88e-41 Height; BRCA cis rs992157 0.796 rs55680399 chr2:219160621 T/C cg00012203 chr2:219082015 ARPC2 0.52 10.51 0.38 6.28e-24 Colorectal cancer; BRCA cis rs478304 0.934 rs1193692 chr11:65504069 A/C cg08755490 chr11:65554678 OVOL1 0.53 10.97 0.4 8.98e-26 Acne (severe); BRCA cis rs12477438 0.501 rs11692336 chr2:99740606 T/C cg08885076 chr2:99613938 TSGA10 0.42 9.73 0.36 5.81e-21 Chronic sinus infection; BRCA cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg24675658 chr1:53192096 ZYG11B -0.61 -13.64 -0.47 2.38e-37 Monocyte count; BRCA cis rs7586879 0.639 rs2384058 chr2:25100328 A/G cg04586622 chr2:25135609 ADCY3 0.43 10.72 0.39 9.03e-25 Body mass index; BRCA cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg13010199 chr12:38710504 ALG10B 0.41 8.87 0.33 7.46e-18 Bladder cancer; BRCA cis rs9467773 0.620 rs9461275 chr6:26590801 C/T cg11502198 chr6:26597334 ABT1 0.58 12.51 0.44 2.71e-32 Intelligence (multi-trait analysis); BRCA cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg13628971 chr7:2884303 GNA12 0.38 8.49 0.32 1.42e-16 Height; BRCA cis rs921968 0.643 rs711186 chr2:219346102 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.11 -0.37 2.13e-22 Mean corpuscular hemoglobin concentration; BRCA cis rs13191362 0.872 rs13194619 chr6:163203657 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.3 0.52 2.95e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4803468 1.000 rs8105833 chr19:41896145 G/A cg09537434 chr19:41945824 ATP5SL -1.0 -24.37 -0.69 2.95e-93 Height; BRCA cis rs9443645 0.901 rs1572585 chr6:79690576 C/T cg11833968 chr6:79620685 NA -0.44 -9.79 -0.36 3.58e-21 Intelligence (multi-trait analysis); BRCA cis rs16976116 0.901 rs2899580 chr15:55491571 A/G cg11288833 chr15:55489084 RSL24D1 0.47 10.57 0.39 3.49e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.27 0.46 1.14e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA cis rs992157 0.560 rs7578940 chr2:219083318 G/T cg20019365 chr2:219134978 PNKD;AAMP -0.42 -9.07 -0.34 1.5e-18 Colorectal cancer; BRCA cis rs11249608 0.510 rs6861539 chr5:178452307 A/G cg21905437 chr5:178450457 ZNF879 0.52 10.83 0.39 3.21e-25 Pubertal anthropometrics; BRCA cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs2153535 0.580 rs2143357 chr6:8497196 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.75 0.39 6.64e-25 Motion sickness; BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg00149659 chr3:10157352 C3orf10 0.81 14.21 0.49 5.29e-40 Alzheimer's disease; BRCA trans rs11098499 0.954 rs6834796 chr4:120414693 A/C cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.63e-30 Corneal astigmatism; BRCA cis rs8103278 1.000 rs1548029 chr19:46309203 A/C cg11657440 chr19:46296263 DMWD -0.53 -12.6 -0.45 1.08e-32 Coronary artery disease; BRCA cis rs72634258 0.554 rs12092614 chr1:7865710 C/T cg26816564 chr1:7831052 VAMP3 0.66 12.26 0.44 3.39e-31 Inflammatory bowel disease; BRCA cis rs7809615 0.792 rs45618033 chr7:99046617 G/A cg12290671 chr7:99195819 NA -0.51 -8.57 -0.32 7.75e-17 Blood metabolite ratios; BRCA cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs523522 0.962 rs10849757 chr12:120964014 G/A cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.43e-36 High light scatter reticulocyte count; BRCA cis rs6977660 0.714 rs10228783 chr7:19789290 C/T cg07541023 chr7:19748670 TWISTNB 0.57 9.68 0.36 9.2e-21 Thyroid stimulating hormone; BRCA cis rs1552244 0.572 rs73117481 chr3:10160132 C/T cg08888203 chr3:10149979 C3orf24 0.65 11.93 0.43 8.91e-30 Alzheimer's disease; BRCA cis rs1400816 0.702 rs1554165 chr2:172551602 T/C cg13550731 chr2:172543902 DYNC1I2 0.54 8.48 0.32 1.56e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg20701182 chr2:24300061 SF3B14 0.62 8.87 0.33 7.2e-18 Lymphocyte counts; BRCA cis rs2576037 0.623 rs2571000 chr18:44580347 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.54 -11.82 -0.42 2.7e-29 Personality dimensions; BRCA cis rs68170813 0.523 rs4730241 chr7:107057361 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.18 -0.31 1.59e-15 Coronary artery disease; BRCA cis rs801193 1.000 rs6975195 chr7:66124774 T/A cg18876405 chr7:65276391 NA -0.63 -15.77 -0.53 1.42e-47 Aortic root size; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.3 10.18 0.37 1.15e-22 Bipolar disorder; BRCA cis rs1448094 0.512 rs11117061 chr12:86250916 G/A cg19622623 chr12:86230825 RASSF9 -0.29 -8.14 -0.31 2.02e-15 Major depressive disorder; BRCA cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg20701182 chr2:24300061 SF3B14 0.66 9.54 0.35 3.02e-20 Lymphocyte counts; BRCA cis rs13040088 1.000 rs2273412 chr20:61553802 G/A cg23096297 chr20:61557774 DIDO1 0.93 18.13 0.58 1.33e-59 Menopause (age at onset); BRCA cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg02734326 chr4:10020555 SLC2A9 0.36 7.86 0.3 1.59e-14 Bone mineral density; BRCA cis rs8114671 0.647 rs1415771 chr20:33734493 G/A cg07148914 chr20:33460835 GGT7 0.35 7.92 0.3 1.08e-14 Height; BRCA cis rs9291683 0.632 rs11734786 chr4:10041499 A/C cg02734326 chr4:10020555 SLC2A9 0.39 8.41 0.32 2.7e-16 Bone mineral density; BRCA cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -11.09 -0.4 2.88e-26 IgG glycosylation; BRCA cis rs17021463 0.902 rs11097413 chr4:95249286 C/T cg11021082 chr4:95130006 SMARCAD1 0.41 9.62 0.36 1.44e-20 Testicular germ cell tumor; BRCA cis rs10870270 0.913 rs4880326 chr10:133745547 C/A cg08754478 chr10:133766260 PPP2R2D -0.69 -14.29 -0.49 2.14e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7772486 0.686 rs857875 chr6:145980033 T/G cg23711669 chr6:146136114 FBXO30 -0.71 -16.86 -0.55 4.78e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs1048238 0.506 rs6668183 chr1:16173814 G/C cg21385522 chr1:16154831 NA 0.48 10.41 0.38 1.5e-23 Systolic blood pressure; BRCA cis rs9443645 0.901 rs7749916 chr6:79814192 A/G cg05283184 chr6:79620031 NA -0.43 -10.85 -0.39 2.82e-25 Intelligence (multi-trait analysis); BRCA cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg18904891 chr8:8559673 CLDN23 0.64 12.33 0.44 1.79e-31 Obesity-related traits; BRCA cis rs6912958 0.781 rs2284908 chr6:88194500 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.45 -8.75 -0.33 1.94e-17 Monocyte percentage of white cells; BRCA cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs12477438 0.520 rs6717729 chr2:99756941 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.55 0.67 2.65e-83 Chronic sinus infection; BRCA cis rs9788682 0.747 rs2568497 chr15:78721397 G/T cg24631222 chr15:78858424 CHRNA5 -0.49 -9.47 -0.35 5.31e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg00149659 chr3:10157352 C3orf10 0.8 14.1 0.49 1.58e-39 Alzheimer's disease; BRCA cis rs7918232 0.941 rs1775350 chr10:27441973 C/T cg14240646 chr10:27532245 ACBD5 0.64 9.49 0.35 4.66e-20 Breast cancer; BRCA cis rs11971779 0.590 rs9642120 chr7:139083971 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs9814567 1.000 rs9869981 chr3:134248801 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1008375 0.966 rs6825133 chr4:17577776 C/T cg16339924 chr4:17578868 LAP3 0.67 17.03 0.56 6.59e-54 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9325144 0.671 rs7306605 chr12:38730471 C/T cg23762105 chr12:34175262 ALG10 -0.41 -10.18 -0.37 1.16e-22 Morning vs. evening chronotype; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg21747090 chr2:27597821 SNX17 -0.44 -9.55 -0.35 2.74e-20 Total body bone mineral density; BRCA cis rs3806843 0.868 rs2262573 chr5:140123627 T/A cg11822812 chr5:140052017 DND1 -0.31 -8.49 -0.32 1.5e-16 Depressive symptoms (multi-trait analysis); BRCA trans rs6952808 0.595 rs3778982 chr7:2166233 T/C cg04565464 chr8:145669602 NFKBIL2 0.42 9.47 0.35 5.25e-20 Bipolar disorder and schizophrenia; BRCA cis rs75804782 0.581 rs3191996 chr2:239344412 A/G cg18131467 chr2:239335373 ASB1 0.63 8.25 0.31 9.1e-16 Morning vs. evening chronotype;Chronotype; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg07262247 chr5:131593730 PDLIM4 -0.36 -8.21 -0.31 1.22e-15 Acylcarnitine levels; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.58 -0.52 1.25e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 1.000 rs35198334 chr3:10104553 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -12.62 -0.45 9.25e-33 Alzheimer's disease; BRCA cis rs4302748 0.862 rs11974209 chr7:36184479 A/G cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs6450176 0.625 rs11747281 chr5:53289047 G/A ch.5.1024479R chr5:53302184 ARL15 -0.68 -15.18 -0.51 1.15e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.25e-23 Motion sickness; BRCA cis rs6952809 0.561 rs1548598 chr7:2438912 T/C cg23289794 chr7:2394357 EIF3B -0.52 -10.24 -0.38 6.86e-23 Multiple sclerosis; BRCA cis rs8072100 0.875 rs12451409 chr17:45544856 A/G cg25173405 chr17:45401733 C17orf57 -0.55 -11.79 -0.42 3.64e-29 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1801251 0.896 rs79793315 chr2:233690864 C/T cg25237894 chr2:233734115 C2orf82 -0.36 -10.62 -0.39 2.2e-24 Coronary artery disease; BRCA cis rs7586879 0.828 rs12986610 chr2:25106265 A/G cg04586622 chr2:25135609 ADCY3 -0.4 -9.9 -0.36 1.31e-21 Body mass index; BRCA cis rs10044254 0.614 rs4574543 chr5:15740147 G/A cg07238450 chr5:15720153 FBXL7 -0.38 -7.89 -0.3 1.35e-14 Asthma (corticosteroid response); BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg18765753 chr7:1198926 ZFAND2A -0.36 -8.01 -0.3 5.25e-15 Longevity;Endometriosis; BRCA cis rs2066819 1.000 rs78149779 chr12:56694817 A/G cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg27661571 chr11:113659931 NA -0.73 -11.27 -0.41 5.14e-27 Hip circumference adjusted for BMI; BRCA cis rs1401999 1.000 rs4148575 chr3:183702275 A/G cg20387954 chr3:183756860 HTR3D 0.45 10.17 0.37 1.31e-22 Anterior chamber depth; BRCA trans rs7613875 0.641 rs6793528 chr3:50100188 C/A cg21659725 chr3:3221576 CRBN -0.35 -8.7 -0.33 2.74e-17 Body mass index; BRCA trans rs12517041 1.000 rs4701360 chr5:23292240 C/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg09658497 chr7:2847517 GNA12 -0.41 -8.67 -0.32 3.44e-17 Height; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg04025307 chr7:1156635 C7orf50 0.72 18.87 0.6 1.92e-63 Longevity;Endometriosis; BRCA cis rs9325144 0.647 rs17518186 chr12:38883665 T/C cg26384229 chr12:38710491 ALG10B -0.51 -12.29 -0.44 2.57e-31 Morning vs. evening chronotype; BRCA cis rs2153535 0.563 rs1796688 chr6:8536423 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.26 0.38 5.62e-23 Motion sickness; BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.71 -13.05 -0.46 1.16e-34 Gut microbiome composition (summer); BRCA cis rs7520050 0.966 rs34102169 chr1:46424864 G/T cg24296786 chr1:45957014 TESK2 0.43 9.56 0.35 2.43e-20 Red blood cell count;Reticulocyte count; BRCA cis rs4077515 0.935 rs3812565 chr9:139272502 T/C cg14169450 chr9:139327907 INPP5E 0.38 8.56 0.32 8.31e-17 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs8114671 0.742 rs6058161 chr20:33620026 C/T cg07148914 chr20:33460835 GGT7 -0.41 -8.94 -0.33 4e-18 Height; BRCA cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg09184832 chr6:79620586 NA -0.48 -10.32 -0.38 3.33e-23 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg23711669 chr6:146136114 FBXO30 0.74 15.73 0.53 2.32e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs7826238 0.539 rs2945891 chr8:8155475 C/T cg08975724 chr8:8085496 FLJ10661 0.51 10.59 0.39 2.92e-24 Systolic blood pressure; BRCA cis rs6062302 0.522 rs13038448 chr20:62218453 C/T cg16989086 chr20:62203971 PRIC285 0.54 9.18 0.34 5.88e-19 Glioblastoma; BRCA trans rs11098499 0.863 rs36040693 chr4:120477616 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg07414643 chr4:187882934 NA 0.28 9.48 0.35 4.74e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs6964587 0.610 rs4729008 chr7:91457054 G/T cg17063962 chr7:91808500 NA 0.54 12.38 0.44 1.08e-31 Breast cancer; BRCA cis rs2111398 0.645 rs7309370 chr12:13053001 A/C cg03534847 chr12:13053055 GPRC5A 0.37 8.61 0.32 5.85e-17 Cutaneous malignant melanoma; BRCA cis rs10501293 1.000 rs6485394 chr11:43080041 A/C cg03447554 chr11:43094025 NA -0.48 -8.92 -0.33 4.75e-18 Cognitive performance; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07343612 chr16:622815 PIGQ -0.67 -22.48 -0.66 6.65e-83 Height; BRCA cis rs7537052 0.646 rs6680302 chr1:36653540 C/T cg24686825 chr1:36642396 MAP7D1 -0.52 -12.11 -0.43 1.5e-30 Schizophrenia; BRCA cis rs909002 0.849 rs3753611 chr1:32082486 C/T cg13919466 chr1:32135498 COL16A1 -0.27 -9.25 -0.34 3.39e-19 Intelligence (multi-trait analysis); BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg07256732 chr16:621771 PIGQ -0.36 -9.51 -0.35 3.73e-20 Height; BRCA cis rs11711311 1.000 rs2305546 chr3:113503354 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.34 8.78 0.33 1.47e-17 IgG glycosylation; BRCA cis rs523522 0.847 rs11065132 chr12:120908459 C/T cg27279351 chr12:120934652 DYNLL1 0.57 13.5 0.47 1.05e-36 High light scatter reticulocyte count; BRCA cis rs1113500 0.933 rs4517375 chr1:108638330 A/C cg06207961 chr1:108661230 NA -0.45 -11.12 -0.4 2.17e-26 Growth-regulated protein alpha levels; BRCA cis rs6973256 0.828 rs10954431 chr7:133430901 A/C cg07491979 chr7:133331646 EXOC4 0.4 8.57 0.32 7.83e-17 Intelligence (multi-trait analysis); BRCA cis rs709400 0.930 rs57447494 chr14:104034569 G/A cg26031613 chr14:104095156 KLC1 1.01 27.66 0.74 2.59e-111 Body mass index; BRCA cis rs2933343 0.729 rs6767104 chr3:128648117 G/T cg25356066 chr3:128598488 ACAD9 -0.37 -8.58 -0.32 7.24e-17 IgG glycosylation; BRCA cis rs16910800 0.731 rs35725172 chr11:23185968 G/A cg20040320 chr11:23191996 NA -0.58 -9.99 -0.37 6.08e-22 Cancer; BRCA cis rs67478160 0.654 rs11628240 chr14:104218135 A/G cg08213375 chr14:104286397 PPP1R13B 0.64 18.05 0.58 3.53e-59 Schizophrenia; BRCA cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.03 0.3 4.61e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs12541635 0.966 rs12674846 chr8:107007178 A/G cg10147462 chr8:107024639 NA 0.37 10.06 0.37 3.49e-22 Age of smoking initiation; BRCA cis rs16958440 1.000 rs76594057 chr18:44637272 A/G cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg12165864 chr7:66369176 NA -0.43 -9.78 -0.36 3.69e-21 Corneal structure; BRCA cis rs7191700 0.583 rs243314 chr16:11385104 G/C cg00044050 chr16:11439710 C16orf75 0.46 11.09 0.4 2.86e-26 Multiple sclerosis; BRCA cis rs4853036 1.000 rs62134009 chr2:70054296 G/A cg02498382 chr2:70120550 SNRNP27 -0.5 -9.2 -0.34 5.09e-19 Colorectal or endometrial cancer; BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg10729496 chr3:10149963 C3orf24 0.46 7.86 0.3 1.59e-14 Alzheimer's disease; BRCA trans rs61931739 1.000 rs12298806 chr12:34036528 C/G cg26384229 chr12:38710491 ALG10B -0.42 -9.38 -0.35 1.09e-19 Morning vs. evening chronotype; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg09177884 chr7:1199841 ZFAND2A -0.36 -8.2 -0.31 1.33e-15 Longevity;Endometriosis; BRCA cis rs1005277 0.579 rs2474584 chr10:38416389 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.13 -0.4 1.98e-26 Extrinsic epigenetic age acceleration; BRCA cis rs12310956 0.532 rs7979535 chr12:33947450 A/C cg06521331 chr12:34319734 NA 0.61 11.02 0.4 5.44e-26 Morning vs. evening chronotype; BRCA cis rs12824058 0.831 rs12310049 chr12:130811260 C/G cg26677194 chr12:130822605 PIWIL1 0.6 14.33 0.49 1.31e-40 Menopause (age at onset); BRCA cis rs1008375 0.863 rs7680984 chr4:17600884 A/G cg16339924 chr4:17578868 LAP3 0.64 15.88 0.53 4.17e-48 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 0.660 rs10263935 chr7:66096028 A/G cg11764359 chr7:65958608 NA 0.59 12.85 0.45 9.21e-34 Aortic root size; BRCA cis rs66887589 0.934 rs7672519 chr4:120544112 C/T cg09307838 chr4:120376055 NA -0.44 -9.13 -0.34 8.96e-19 Diastolic blood pressure; BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26314531 chr2:26401878 FAM59B -0.87 -16.3 -0.54 3.37e-50 Gut microbiome composition (summer); BRCA cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg02544614 chr20:61657117 NA 0.29 8.16 0.31 1.77e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs2204008 0.837 rs7315255 chr12:37949279 G/A cg06521331 chr12:34319734 NA -0.54 -9.7 -0.36 7.7e-21 Bladder cancer; BRCA cis rs936229 0.784 rs12906946 chr15:75153140 A/G cg10253484 chr15:75165896 SCAMP2 -0.58 -11.0 -0.4 6.64e-26 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg18765753 chr7:1198926 ZFAND2A -0.54 -13.86 -0.48 2.13e-38 Longevity;Endometriosis; BRCA cis rs2580764 0.598 rs6755468 chr2:55240026 A/C cg09592903 chr2:55203963 RTN4 -0.4 -10.35 -0.38 2.64e-23 Mean platelet volume; BRCA cis rs9790314 0.715 rs7622047 chr3:160770505 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -8.78 -0.33 1.5e-17 Morning vs. evening chronotype; BRCA trans rs1994135 0.617 rs10743824 chr12:33733764 C/T cg26384229 chr12:38710491 ALG10B 0.39 8.92 0.33 4.94e-18 Resting heart rate; BRCA cis rs6088580 0.634 rs6058073 chr20:33116483 T/C cg06115741 chr20:33292138 TP53INP2 0.39 8.63 0.32 4.81e-17 Glomerular filtration rate (creatinine); BRCA cis rs7973719 0.868 rs7315553 chr12:7353838 A/C cg07052231 chr12:7363540 PEX5 0.36 8.21 0.31 1.23e-15 IgG glycosylation; BRCA cis rs9814567 1.000 rs6806417 chr3:134211446 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 9.1 0.34 1.15e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6120849 0.754 rs6120790 chr20:33599090 A/T cg24642439 chr20:33292090 TP53INP2 0.59 10.21 0.37 8.99e-23 Protein C levels; BRCA trans rs75804782 0.521 rs55690022 chr2:239407783 C/T cg01134436 chr17:81009848 B3GNTL1 0.67 8.56 0.32 8.1e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg16405210 chr4:1374714 KIAA1530 -0.93 -20.93 -0.64 1.72e-74 Longevity; BRCA cis rs1595825 0.891 rs77706948 chr2:198608441 T/G cg19156104 chr2:198669113 PLCL1 -0.48 -8.58 -0.32 7.39e-17 Ulcerative colitis; BRCA cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -11.41 -0.41 1.37e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9443645 0.869 rs1567168 chr6:79536455 G/T cg11833968 chr6:79620685 NA -0.43 -9.61 -0.36 1.6e-20 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.580 rs2152347 chr6:8474281 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.44 0.35 6.85e-20 Motion sickness; BRCA cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg11058730 chr11:34937778 PDHX;APIP -0.68 -15.99 -0.53 1.2e-48 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs10927875 0.619 rs12121764 chr1:16138059 A/T cg16109817 chr1:16162209 FLJ37453 0.35 10.2 0.37 9.83e-23 Dilated cardiomyopathy; BRCA cis rs8114671 0.647 rs6060268 chr20:33734293 T/C cg07148914 chr20:33460835 GGT7 0.35 7.92 0.3 1.08e-14 Height; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg00106254 chr7:1943704 MAD1L1 -0.46 -12.31 -0.44 2.1e-31 Bipolar disorder and schizophrenia; BRCA cis rs72781680 1.000 rs72796357 chr2:24160131 A/G cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs11190604 1.000 rs2495743 chr10:102329739 G/C cg07080220 chr10:102295463 HIF1AN 0.63 13.75 0.48 7.42e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2625529 0.824 rs12595228 chr15:72267215 T/C cg16672083 chr15:72433130 SENP8 -0.85 -17.65 -0.57 4.2e-57 Red blood cell count; BRCA cis rs2836974 0.897 rs35386515 chr21:40532047 C/T cg11644478 chr21:40555479 PSMG1 0.82 18.58 0.59 6.03e-62 Cognitive function; BRCA trans rs561341 1.000 rs548957 chr17:30302411 G/A cg20587970 chr11:113659929 NA -1.2 -22.15 -0.66 4.31e-81 Hip circumference adjusted for BMI; BRCA cis rs12210905 0.688 rs12209905 chr6:27404592 C/G cg08851530 chr6:28072375 NA 0.81 7.89 0.3 1.3e-14 Hip circumference adjusted for BMI; BRCA cis rs2153535 0.580 rs7341383 chr6:8470634 A/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs3091242 1.000 rs9689 chr1:25688276 A/G cg27572855 chr1:25598939 RHD 0.45 13.13 0.46 5.11e-35 Erythrocyte sedimentation rate; BRCA cis rs2075371 1.000 rs2598288 chr7:133977304 A/T cg02659138 chr7:134003124 SLC35B4 0.33 10.13 0.37 1.75e-22 Mean platelet volume; BRCA cis rs9486719 0.741 rs976356 chr6:96849437 T/A cg06623918 chr6:96969491 KIAA0776 0.75 12.34 0.44 1.59e-31 Migraine;Coronary artery disease; BRCA cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg06212747 chr3:49208901 KLHDC8B 0.59 8.28 0.31 7.36e-16 Menarche (age at onset); BRCA cis rs4919694 0.572 rs12255989 chr10:104867206 C/T cg04362960 chr10:104952993 NT5C2 0.73 12.72 0.45 3.27e-33 Arsenic metabolism; BRCA cis rs2576037 0.526 rs2510444 chr18:44376849 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.35 8.41 0.32 2.77e-16 Personality dimensions; BRCA cis rs2777491 1.000 rs316605 chr15:41771591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.88 -0.53 4.3e-48 Ulcerative colitis; BRCA cis rs763121 0.853 rs6001191 chr22:39074452 T/C cg14440974 chr22:39074834 NA -0.38 -9.13 -0.34 8.96e-19 Menopause (age at onset); BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg08470875 chr2:26401718 FAM59B 0.76 12.04 0.43 3.12e-30 Gut microbiome composition (summer); BRCA cis rs4713118 0.869 rs9468214 chr6:27713299 G/C cg20933634 chr6:27740509 NA 0.45 9.01 0.34 2.33e-18 Parkinson's disease; BRCA cis rs769267 0.930 rs2304098 chr19:19646272 T/C cg03709012 chr19:19516395 GATAD2A 0.8 18.53 0.59 1.15e-61 Tonsillectomy; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg26314531 chr2:26401878 FAM59B -0.59 -10.11 -0.37 2.09e-22 Gut microbiome composition (summer); BRCA cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg00152838 chr16:24741724 TNRC6A -0.37 -7.98 -0.3 6.84e-15 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.623 rs9485021 chr6:146068797 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -17.11 -0.56 2.7e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs7493 1.000 rs12026 chr7:95041016 G/C cg19678392 chr7:94953810 PON1 -0.43 -9.1 -0.34 1.11e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2979489 0.591 rs62508371 chr8:30422060 C/T cg26383811 chr8:30366931 RBPMS -0.51 -12.01 -0.43 4.22e-30 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs78456975 0.657 rs116217838 chr2:1569173 T/C cg01028140 chr2:1542097 TPO -0.57 -11.78 -0.42 4.16e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg22875332 chr1:76189707 ACADM -0.68 -14.52 -0.5 1.81e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6142102 0.602 rs2268086 chr20:32648738 C/T cg24642439 chr20:33292090 TP53INP2 -0.38 -7.87 -0.3 1.47e-14 Skin pigmentation; BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.76 0.67 2.09e-84 Platelet count; BRCA cis rs1580019 0.587 rs10951338 chr7:32560089 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.71 0.39 1.01e-24 Cognitive ability; BRCA cis rs35123781 0.696 rs13154510 chr5:139071301 A/C cg10513866 chr5:139070639 NA 0.44 9.71 0.36 6.9e-21 Schizophrenia; BRCA trans rs3733585 0.683 rs13112015 chr4:9933796 C/T cg26043149 chr18:55253948 FECH -0.41 -9.02 -0.34 2.11e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3768617 0.706 rs10797801 chr1:182971965 G/T ch.1.3577855R chr1:183094577 LAMC1 0.5 11.66 0.42 1.28e-28 Fuchs's corneal dystrophy; BRCA cis rs1451375 0.652 rs7779110 chr7:50625651 T/C cg18232548 chr7:50535776 DDC 0.38 8.01 0.3 5.28e-15 Malaria; BRCA cis rs10504229 0.728 rs72650858 chr8:58152832 G/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs60871478 1.000 rs9195 chr7:825786 C/T cg05535760 chr7:792225 HEATR2 -0.73 -13.41 -0.47 2.7e-36 Cerebrospinal P-tau181p levels; BRCA cis rs1153858 1.000 rs8042786 chr15:45703539 T/C cg14582100 chr15:45693742 SPATA5L1 0.37 11.67 0.42 1.17e-28 Homoarginine levels; BRCA cis rs12545109 0.876 rs1992120 chr8:57337112 G/A cg09654669 chr8:57350985 NA -0.43 -8.01 -0.3 5.39e-15 Obesity-related traits; BRCA cis rs12431939 1.000 rs11845886 chr14:51635873 G/A cg23942311 chr14:51606299 NA -0.43 -8.29 -0.31 6.89e-16 Cancer; BRCA cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg05084668 chr3:125655381 ALG1L -0.47 -8.05 -0.3 4.02e-15 Blood pressure (smoking interaction); BRCA cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.17 0.31 1.68e-15 Depression; BRCA cis rs4689388 0.824 rs6446482 chr4:6295693 C/G cg25554036 chr4:6271136 WFS1 0.41 9.58 0.35 2.18e-20 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 0.97 18.22 0.58 5.01e-60 Platelet count; BRCA cis rs752010 0.967 rs6675999 chr1:42099024 T/G cg06885757 chr1:42089581 HIVEP3 0.25 8.86 0.33 8.07e-18 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs3858526 0.642 rs55732658 chr11:5894602 A/C cg05234568 chr11:5960015 NA -0.41 -7.92 -0.3 1.02e-14 DNA methylation (variation); BRCA cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg02951883 chr7:2050386 MAD1L1 0.44 10.65 0.39 1.68e-24 Schizophrenia; BRCA cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg08601574 chr20:25228251 PYGB -0.39 -9.0 -0.34 2.53e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6762477 0.748 rs34877766 chr3:50234126 A/G cg05623727 chr3:50126028 RBM5 0.37 8.48 0.32 1.62e-16 Menarche (age at onset); BRCA cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.05 -0.4 4.41e-26 IgG glycosylation; BRCA cis rs9649213 0.593 rs13246942 chr7:97915021 C/T cg24562669 chr7:97807699 LMTK2 0.47 12.62 0.45 8.93e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs7945705 0.747 rs11042150 chr11:9010819 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.19 -0.49 5.99e-40 Hemoglobin concentration; BRCA cis rs12701220 0.655 rs9638973 chr7:1133678 A/G cg02733842 chr7:1102375 C7orf50 -0.64 -11.8 -0.42 3.32e-29 Bronchopulmonary dysplasia; BRCA cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs11577318 0.853 rs2276712 chr1:26627478 T/C cg07461501 chr17:79650226 HGS;ARL16 0.4 10.08 0.37 2.87e-22 Granulocyte percentage of myeloid white cells; BRCA cis rs637571 0.726 rs669371 chr11:65674153 G/T cg04055107 chr11:65626734 MUS81;CFL1 -0.41 -8.63 -0.32 4.8e-17 Eosinophil percentage of white cells; BRCA trans rs11098499 0.863 rs10030660 chr4:120436704 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.13 0.31 2.2e-15 Corneal astigmatism; BRCA cis rs35306767 0.903 rs12769431 chr10:922633 T/C cg20503657 chr10:835505 NA 1.03 18.27 0.59 2.63e-60 Eosinophil percentage of granulocytes; BRCA cis rs8180040 1.000 rs11714294 chr3:47339723 G/A cg16586182 chr3:47516702 SCAP 0.62 14.44 0.5 4.04e-41 Colorectal cancer; BRCA cis rs6748734 0.817 rs4465762 chr2:241798862 G/A cg07537917 chr2:241836409 C2orf54 -0.43 -10.39 -0.38 1.73e-23 Urinary metabolites; BRCA cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg23711669 chr6:146136114 FBXO30 0.74 15.67 0.53 4.66e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs651907 0.535 rs13094753 chr3:101525082 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.46 0.47 1.63e-36 Colorectal cancer; BRCA cis rs992157 0.560 rs7605980 chr2:219100869 C/G cg00012203 chr2:219082015 ARPC2 0.58 11.99 0.43 5e-30 Colorectal cancer; BRCA cis rs35110281 0.720 rs162376 chr21:44926759 G/T cg04455712 chr21:45112962 RRP1B -0.43 -11.03 -0.4 5.21e-26 Mean corpuscular volume; BRCA cis rs7615952 0.599 rs2270986 chr3:125701099 T/C cg18479299 chr3:125709523 NA -0.54 -8.46 -0.32 1.84e-16 Blood pressure (smoking interaction); BRCA cis rs3936840 0.539 rs3742445 chr14:102975552 T/A cg18135206 chr14:102964638 TECPR2 0.48 9.53 0.35 3.23e-20 Plateletcrit; BRCA cis rs875971 0.660 rs28698552 chr7:66005018 A/G cg11764359 chr7:65958608 NA 0.67 15.2 0.52 9.48e-45 Aortic root size; BRCA cis rs35306767 0.855 rs34318754 chr10:890714 G/A cg20503657 chr10:835505 NA 1.3 21.72 0.65 9.26e-79 Eosinophil percentage of granulocytes; BRCA cis rs17818399 0.926 rs35682608 chr2:46836542 A/T cg02822958 chr2:46747628 ATP6V1E2 0.55 9.9 0.36 1.33e-21 Height; BRCA trans rs61931739 0.500 rs7137392 chr12:34447074 T/C cg13010199 chr12:38710504 ALG10B 0.42 9.01 0.34 2.3e-18 Morning vs. evening chronotype; BRCA cis rs6565180 0.926 rs12446288 chr16:30388709 A/G cg17640201 chr16:30407289 ZNF48 0.83 21.68 0.65 1.45e-78 Tonsillectomy; BRCA cis rs6688613 0.694 rs3820387 chr1:166820284 A/T ch.1.3259774R chr1:166827647 TADA1 0.41 8.55 0.32 8.97e-17 Refractive astigmatism; BRCA trans rs783540 0.656 rs783538 chr15:83253143 C/G cg18393722 chr15:85113863 UBE2QP1 -0.32 -8.89 -0.33 6.06e-18 Schizophrenia; BRCA trans rs3812049 0.784 rs7734927 chr5:127453735 T/A cg16011800 chr17:1958478 HIC1 -0.54 -8.92 -0.33 4.81e-18 Lymphocyte counts;Red cell distribution width; BRCA cis rs9467773 0.525 rs1535274 chr6:26520747 A/C cg11502198 chr6:26597334 ABT1 0.61 11.53 0.41 4.48e-28 Intelligence (multi-trait analysis); BRCA cis rs2251381 0.515 rs2832299 chr21:30749237 G/C cg08807101 chr21:30365312 RNF160 0.36 8.11 0.31 2.69e-15 Selective IgA deficiency; BRCA cis rs4906332 1.000 rs7155822 chr14:103922390 A/G cg26031613 chr14:104095156 KLC1 -0.45 -8.1 -0.3 2.88e-15 Coronary artery disease; BRCA cis rs992157 0.735 rs13430006 chr2:219113089 A/C cg00012203 chr2:219082015 ARPC2 -0.73 -16.29 -0.54 3.74e-50 Colorectal cancer; BRCA cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg22508957 chr16:3507546 NAT15 0.65 11.23 0.41 8.06e-27 Tuberculosis; BRCA cis rs9296092 0.538 rs56205713 chr6:33517510 A/G cg13560919 chr6:33536144 NA -0.84 -18.3 -0.59 1.78e-60 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs10992471 0.603 rs7873397 chr9:95205928 G/C cg14631576 chr9:95140430 CENPP -0.39 -9.32 -0.35 1.83e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg23815491 chr16:72088622 HP -0.35 -8.46 -0.32 1.8e-16 Fibrinogen levels; BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg04267008 chr7:1944627 MAD1L1 -0.6 -12.84 -0.45 9.34e-34 Bipolar disorder and schizophrenia; BRCA cis rs757110 0.770 rs11024268 chr11:17387982 A/G cg03864215 chr11:17408437 KCNJ11 -0.27 -8.0 -0.3 5.96e-15 Type 2 diabetes; BRCA cis rs7772486 0.875 rs2224121 chr6:146343214 G/A cg13319975 chr6:146136371 FBXO30 -0.36 -8.37 -0.31 3.72e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.866 rs3756156 chr4:120524841 G/A cg09307838 chr4:120376055 NA 0.68 13.62 0.47 2.83e-37 Corneal astigmatism; BRCA cis rs6089584 0.627 rs55875402 chr20:60559925 G/A cg13770153 chr20:60521292 NA -0.4 -9.44 -0.35 6.84e-20 Body mass index; BRCA cis rs796364 0.806 rs203769 chr2:200900866 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.61 -9.73 -0.36 5.73e-21 Schizophrenia; BRCA cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg25427524 chr10:38739819 LOC399744 -0.65 -15.67 -0.53 4.79e-47 Extrinsic epigenetic age acceleration; BRCA cis rs4787491 0.679 rs12933575 chr16:30022564 A/G cg06326092 chr16:30034487 C16orf92 0.33 8.46 0.32 1.83e-16 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs425277 0.538 rs169037 chr1:2095582 G/T cg24578937 chr1:2090814 PRKCZ 0.36 11.33 0.41 3.16e-27 Height; BRCA cis rs6565180 0.926 rs8046445 chr16:30386262 A/G cg17640201 chr16:30407289 ZNF48 -0.8 -20.39 -0.63 1.42e-71 Tonsillectomy; BRCA cis rs1707322 1.000 rs785507 chr1:46541558 C/T cg06784218 chr1:46089804 CCDC17 -0.48 -11.26 -0.41 6.11e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs701145 0.585 rs1542254 chr3:153864296 C/T cg12800244 chr3:153838788 SGEF 0.58 8.15 0.31 1.9e-15 Coronary artery disease; BRCA trans rs3733585 0.598 rs28677023 chr4:9958326 C/A cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs7617773 0.817 rs13059037 chr3:48287879 A/G cg11946769 chr3:48343235 NME6 0.67 13.85 0.48 2.39e-38 Coronary artery disease; BRCA cis rs9682041 0.696 rs10936627 chr3:170104406 C/T cg11886554 chr3:170076028 SKIL 0.51 10.18 0.37 1.22e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs950776 0.518 rs12902493 chr15:78819275 C/G cg06917634 chr15:78832804 PSMA4 0.77 17.59 0.57 8.51e-57 Sudden cardiac arrest; BRCA cis rs34779708 0.966 rs57081218 chr10:35434608 A/G cg03585969 chr10:35415529 CREM 0.45 9.47 0.35 5.12e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs701145 0.537 rs437396 chr3:153923273 A/G cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs2841277 0.738 rs1036713 chr14:105396693 C/G cg19901468 chr14:105411992 AHNAK2 0.5 11.75 0.42 5.3e-29 Rheumatoid arthritis; BRCA cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.81 -0.42 3.09e-29 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg22907277 chr7:1156413 C7orf50 0.45 10.41 0.38 1.49e-23 Longevity;Endometriosis; BRCA cis rs60154123 0.505 rs1319435 chr1:210047618 C/T cg22029157 chr1:209979665 IRF6 -0.51 -8.16 -0.31 1.82e-15 Coronary artery disease; BRCA cis rs40363 0.645 rs1635392 chr16:3517581 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.44 -8.33 -0.31 4.84e-16 Tuberculosis; BRCA cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -18.24 -0.59 3.68e-60 Extrinsic epigenetic age acceleration; BRCA cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg25319279 chr11:5960081 NA -0.43 -8.37 -0.31 3.65e-16 DNA methylation (variation); BRCA cis rs68170813 0.559 rs7803290 chr7:106907353 T/C cg02696742 chr7:106810147 HBP1 -0.53 -8.67 -0.32 3.43e-17 Coronary artery disease; BRCA cis rs7618915 0.547 rs68021750 chr3:52624769 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.26 0.38 5.81e-23 Bipolar disorder; BRCA cis rs490234 0.932 rs506874 chr9:128319066 G/A cg14078157 chr9:128172775 NA 0.33 7.89 0.3 1.3e-14 Mean arterial pressure; BRCA cis rs17376456 0.825 rs13361613 chr5:93272176 C/T cg21475434 chr5:93447410 FAM172A 0.66 8.73 0.33 2.29e-17 Diabetic retinopathy; BRCA cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg05623727 chr3:50126028 RBM5 -0.42 -10.06 -0.37 3.34e-22 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.943 rs10424574 chr19:37838393 A/G cg23950597 chr19:37808831 NA -0.72 -12.59 -0.45 1.28e-32 Coronary artery calcification; BRCA cis rs3733585 0.637 rs6850684 chr4:9964380 G/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg13047869 chr3:10149882 C3orf24 0.58 12.11 0.43 1.53e-30 Alzheimer's disease; BRCA cis rs477692 0.905 rs489966 chr10:131422115 C/G cg05714579 chr10:131428358 MGMT -0.58 -14.07 -0.49 2.21e-39 Response to temozolomide; BRCA cis rs2549003 1.000 rs2706384 chr5:131826880 G/T cg02551604 chr5:131831745 NA 0.4 15.16 0.51 1.43e-44 Asthma (sex interaction); BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg23978390 chr7:1156363 C7orf50 0.42 10.08 0.37 2.76e-22 Longevity;Endometriosis; BRCA cis rs12477438 0.520 rs11685759 chr2:99766217 T/C cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.46e-23 Chronic sinus infection; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg04013093 chr6:42928303 GNMT -0.28 -8.53 -0.32 1.05e-16 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg06808227 chr14:105710500 BRF1 -0.79 -16.18 -0.54 1.36e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs13082711 0.595 rs17317435 chr3:27339326 A/G cg02860705 chr3:27208620 NA 0.78 14.65 0.5 4.32e-42 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg00106254 chr7:1943704 MAD1L1 -0.41 -10.53 -0.38 5.08e-24 Bipolar disorder and schizophrenia; BRCA cis rs61931739 0.500 rs10844844 chr12:34380350 G/T cg06521331 chr12:34319734 NA -0.55 -10.13 -0.37 1.88e-22 Morning vs. evening chronotype; BRCA cis rs2249625 0.545 rs2463743 chr6:72874741 C/T cg18830697 chr6:72922368 RIMS1 -0.64 -14.66 -0.5 3.57e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs801193 0.844 rs732465 chr7:65998450 T/C cg11764359 chr7:65958608 NA 0.62 13.19 0.46 2.52e-35 Aortic root size; BRCA cis rs12477438 0.520 rs4347885 chr2:99804007 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.49 0.63 3.97e-72 Chronic sinus infection; BRCA cis rs17818399 0.926 rs13033177 chr2:46831062 C/A cg02822958 chr2:46747628 ATP6V1E2 0.55 9.85 0.36 2.13e-21 Height; BRCA cis rs838147 0.537 rs632111 chr19:49208978 A/G cg07051648 chr19:49177693 NTN5;SEC1 -0.42 -8.1 -0.31 2.85e-15 Dietary macronutrient intake; BRCA cis rs736408 0.505 rs2083180 chr3:52668119 G/T cg10802521 chr3:52805072 NEK4 -0.33 -9.03 -0.34 2.06e-18 Bipolar disorder; BRCA cis rs700651 0.757 rs6748683 chr2:198878008 T/A cg00792783 chr2:198669748 PLCL1 0.42 9.31 0.35 1.96e-19 Intracranial aneurysm; BRCA cis rs7177699 0.557 rs55870734 chr15:79117917 A/T cg00540400 chr15:79124168 NA -0.28 -7.89 -0.3 1.33e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs4363385 0.747 rs1415960 chr1:152973571 G/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.81 -0.36 2.89e-21 Inflammatory skin disease; BRCA cis rs1707322 0.685 rs28617418 chr1:46189526 T/A cg06784218 chr1:46089804 CCDC17 0.51 12.23 0.44 4.9e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4727027 0.933 rs28767030 chr7:148825918 T/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 9.02 0.34 2.2e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7666738 0.645 rs10013290 chr4:99082799 G/A cg05340658 chr4:99064831 C4orf37 0.64 14.83 0.51 5.78e-43 Colonoscopy-negative controls vs population controls; BRCA trans rs2204008 0.712 rs12371182 chr12:38321143 A/C cg06521331 chr12:34319734 NA -0.52 -9.39 -0.35 1.08e-19 Bladder cancer; BRCA cis rs4363385 0.747 rs946099 chr1:152971618 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.28 -0.31 7.41e-16 Inflammatory skin disease; BRCA cis rs12042938 0.600 rs823161 chr1:231775017 G/A cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX 0.41 8.9 0.33 5.73e-18 Neuranatomic and neurocognitive phenotypes; BRCA cis rs7809950 1.000 rs2237676 chr7:107198079 C/A cg23024343 chr7:107201750 COG5 -0.4 -9.05 -0.34 1.71e-18 Coronary artery disease; BRCA cis rs965469 0.696 rs6037570 chr20:3334292 C/A cg25506879 chr20:3388711 C20orf194 -0.42 -8.09 -0.3 2.93e-15 IFN-related cytopenia; BRCA cis rs2576037 0.526 rs658756 chr18:44431832 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.69 0.33 3e-17 Personality dimensions; BRCA cis rs10504229 0.683 rs73603874 chr8:58108340 G/A cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.798 rs4851179 chr2:99568774 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.92 -0.51 2.19e-43 Chronic sinus infection; BRCA cis rs2576037 0.526 rs3892820 chr18:44479558 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 8.99 0.34 2.7e-18 Personality dimensions; BRCA cis rs4363385 0.703 rs4845517 chr1:153003893 T/A cg25856811 chr1:152973957 SPRR3 -0.31 -8.27 -0.31 7.82e-16 Inflammatory skin disease; BRCA cis rs10504073 0.584 rs1511368 chr8:49949523 A/T cg00325661 chr8:49890786 NA 0.45 13.07 0.46 9.48e-35 Blood metabolite ratios; BRCA cis rs61931739 0.500 rs11053218 chr12:34474792 A/C cg06521331 chr12:34319734 NA 0.49 8.78 0.33 1.47e-17 Morning vs. evening chronotype; BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -8.26 -0.31 8.36e-16 Total body bone mineral density; BRCA cis rs875971 1.000 rs2077593 chr7:65892530 A/G cg18876405 chr7:65276391 NA 0.55 13.26 0.46 1.28e-35 Aortic root size; BRCA cis rs8141529 0.748 rs1318026 chr22:29283518 A/G cg15103426 chr22:29168792 CCDC117 0.51 11.82 0.42 2.6e-29 Lymphocyte counts; BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.78 0.36 3.7e-21 Gut microbiome composition (summer); BRCA cis rs12618769 0.597 rs11902825 chr2:99129137 T/C cg10123293 chr2:99228465 UNC50 0.42 8.19 0.31 1.38e-15 Bipolar disorder; BRCA cis rs11252926 0.502 rs7072510 chr10:455596 C/T cg18196295 chr10:418757 DIP2C 0.5 11.87 0.43 1.59e-29 Psychosis in Alzheimer's disease; BRCA cis rs7666738 0.606 rs7663216 chr4:99088385 A/C cg05340658 chr4:99064831 C4orf37 0.48 10.66 0.39 1.61e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs7820559 chr8:58142662 C/T cg20607798 chr8:58055168 NA 0.46 8.15 0.31 1.91e-15 Developmental language disorder (linguistic errors); BRCA cis rs7811142 1.000 rs11764818 chr7:100043055 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.07 21.36 0.65 8.04e-77 Platelet count; BRCA cis rs4268898 0.662 rs56006260 chr2:24409903 A/G cg08917208 chr2:24149416 ATAD2B 0.53 8.25 0.31 8.81e-16 Asthma; BRCA cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.55 11.92 0.43 1e-29 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.84 -0.33 9.58e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs6545883 0.929 rs7606167 chr2:61742654 C/G cg15711740 chr2:61764176 XPO1 -0.56 -14.22 -0.49 4.63e-40 Tuberculosis; BRCA cis rs6430585 0.583 rs7561565 chr2:136640787 A/C cg07169764 chr2:136633963 MCM6 1.15 23.84 0.69 2.37e-90 Corneal structure; BRCA trans rs800082 0.646 rs2717394 chr3:144280612 A/T cg24215973 chr2:240111563 HDAC4 0.4 10.35 0.38 2.57e-23 Smoking behavior; BRCA cis rs8062405 0.929 rs11864750 chr16:28875204 A/T cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7615952 0.576 rs2276729 chr3:125826214 G/A cg06494592 chr3:125709126 NA -0.52 -8.52 -0.32 1.15e-16 Blood pressure (smoking interaction); BRCA cis rs311392 1.000 rs2671804 chr8:55088853 C/T cg11783602 chr8:55087084 NA -0.33 -9.61 -0.36 1.58e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs9814567 1.000 rs6763088 chr3:134254989 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4803468 1.000 rs2241710 chr19:41912092 G/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.65 -0.68 2.59e-89 Height; BRCA cis rs9807989 0.507 rs6758936 chr2:102991369 A/G cg03938978 chr2:103052716 IL18RAP -0.29 -8.61 -0.32 5.69e-17 Asthma; BRCA cis rs17270561 0.609 rs9348694 chr6:25753640 C/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.69 0.33 3.01e-17 Iron status biomarkers; BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg16606324 chr3:10149918 C3orf24 0.52 8.84 0.33 9.31e-18 Alzheimer's disease; BRCA cis rs875971 0.660 rs13224319 chr7:66007363 A/G cg11764359 chr7:65958608 NA 0.68 15.19 0.52 9.94e-45 Aortic root size; BRCA cis rs17401966 1.000 rs12130220 chr1:10359944 T/G cg03954927 chr1:10346856 KIF1B 0.45 13.17 0.46 3.26e-35 Hepatocellular carcinoma; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg10729496 chr3:10149963 C3orf24 0.42 8.08 0.3 3.25e-15 Alzheimer's disease; BRCA trans rs11764590 0.715 rs55770986 chr7:2087823 T/C cg25206134 chr2:45395956 NA 0.52 8.47 0.32 1.63e-16 Neuroticism; BRCA cis rs1865721 1.000 rs72977879 chr18:73193696 T/C cg26385618 chr18:73139727 C18orf62 -0.39 -9.0 -0.34 2.66e-18 Intelligence; BRCA cis rs17376456 0.825 rs10064368 chr5:93266396 C/A cg25358565 chr5:93447407 FAM172A 1.16 18.43 0.59 3.73e-61 Diabetic retinopathy; BRCA cis rs4363385 0.720 rs11205150 chr1:152959266 C/T cg21543102 chr1:152974771 SPRR3 -0.3 -8.75 -0.33 1.84e-17 Inflammatory skin disease; BRCA cis rs7246967 0.541 rs16999009 chr19:22909658 A/G cg23217946 chr19:22817039 ZNF492 -0.48 -8.69 -0.32 3.13e-17 Bronchopulmonary dysplasia; BRCA cis rs13082711 0.520 rs2643825 chr3:27562613 A/G cg02860705 chr3:27208620 NA 0.42 8.41 0.32 2.6e-16 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs1003719 0.751 rs2835585 chr21:38460488 T/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.1 0.49 1.6e-39 Eye color traits; BRCA cis rs514406 0.525 rs269291 chr1:53189297 C/T cg08859206 chr1:53392774 SCP2 -0.4 -7.9 -0.3 1.26e-14 Monocyte count; BRCA cis rs7666738 0.830 rs60411337 chr4:99046617 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.877 rs28633397 chr5:93447048 A/G cg25358565 chr5:93447407 FAM172A 1.19 19.65 0.61 1.39e-67 Diabetic retinopathy; BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg05279229 chr7:1896384 MAD1L1 -0.42 -7.81 -0.3 2.29e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs2974760 0.606 rs6600143 chr16:201389 A/C cg08400316 chr16:204221 HBZ -0.75 -16.57 -0.55 1.36e-51 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 8.02e-41 Motion sickness; BRCA cis rs7847628 0.551 rs10818476 chr9:123572038 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.85 20.73 0.63 2.18e-73 Birth weight; BRCA cis rs2730245 1.000 rs6965685 chr7:158726462 C/T cg24397884 chr7:158709396 WDR60 0.97 24.77 0.7 1.81e-95 Height; BRCA cis rs10751667 0.666 rs7934963 chr11:957220 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.89 0.53 3.78e-48 Alzheimer's disease (late onset); BRCA cis rs6088580 0.634 rs4911419 chr20:32995873 G/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs6089829 0.889 rs6122348 chr20:61663921 C/T cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs6724607 1.000 rs6724607 chr2:191466532 C/T cg27211696 chr2:191398769 TMEM194B 0.52 11.91 0.43 1.14e-29 Pulse pressure; BRCA cis rs1891275 0.515 rs11186666 chr10:93477919 T/C cg07889827 chr10:93443413 NA -0.4 -10.9 -0.4 1.76e-25 Intelligence (multi-trait analysis); BRCA cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg01802117 chr1:53393560 SCP2 -0.36 -8.38 -0.31 3.43e-16 Monocyte count; BRCA cis rs6831352 0.918 rs13129488 chr4:100053025 G/T cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs17376456 0.877 rs10476601 chr5:93402522 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.42 0.32 2.47e-16 Diabetic retinopathy; BRCA trans rs11088226 0.681 rs16989507 chr21:33939509 T/G cg09050820 chr6:167586206 TCP10L2 0.77 13.24 0.46 1.49e-35 Gastritis; BRCA cis rs13046373 0.535 rs13051529 chr21:32029743 G/C cg16812893 chr21:31813075 KRTAP15-1 0.37 9.08 0.34 1.3e-18 HDL cholesterol; BRCA cis rs2180341 1.000 rs6903878 chr6:127638600 C/G cg27446573 chr6:127587934 RNF146 0.9 21.32 0.64 1.39e-76 Breast cancer; BRCA cis rs1707322 0.686 rs3014242 chr1:46087577 G/A cg06784218 chr1:46089804 CCDC17 -0.54 -13.13 -0.46 4.69e-35 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3784262 0.616 rs2704197 chr15:58323236 C/T cg12031962 chr15:58353849 ALDH1A2 -0.34 -8.6 -0.32 6.14e-17 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1904096 0.506 rs11097408 chr4:95165662 T/C cg11021082 chr4:95130006 SMARCAD1 -0.41 -9.51 -0.35 3.81e-20 Type 2 diabetes; BRCA cis rs2806561 0.929 rs641452 chr1:23538386 A/G cg19743168 chr1:23544995 NA 0.47 11.73 0.42 6.7200000000000006e-29 Height; BRCA cis rs16910800 0.731 rs7125729 chr11:23181637 A/G cg20040320 chr11:23191996 NA -0.59 -10.15 -0.37 1.47e-22 Cancer; BRCA cis rs875971 0.520 rs2420597 chr7:65915986 A/G cg11764359 chr7:65958608 NA 0.76 17.07 0.56 4.29e-54 Aortic root size; BRCA trans rs6479891 1.000 rs4746994 chr10:64905324 T/A cg14819942 chr15:35414228 NA 0.35 8.54 0.32 1e-16 Arthritis (juvenile idiopathic); BRCA cis rs4660306 1.000 rs11211132 chr1:45990516 T/C cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.94 -0.3 9.19e-15 Homocysteine levels; BRCA cis rs1448094 0.549 rs57614821 chr12:86235361 A/C cg19622623 chr12:86230825 RASSF9 -0.3 -8.29 -0.31 6.78e-16 Major depressive disorder; BRCA trans rs12458462 0.509 rs3786241 chr18:77494328 A/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.45 -9.4 -0.35 9.56e-20 Monocyte count; BRCA cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg01849466 chr14:104193079 ZFYVE21 -0.49 -10.58 -0.39 3.13e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9660992 0.710 rs1768587 chr1:205236432 C/T cg00857998 chr1:205179979 DSTYK 0.45 8.41 0.32 2.62e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs7236492 0.505 rs11663549 chr18:77181989 A/G cg15644404 chr18:77186268 NFATC1 0.67 8.14 0.31 2.08e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3820928 0.839 rs58580037 chr2:227876274 G/T cg11843606 chr2:227700838 RHBDD1 -0.37 -8.08 -0.3 3.23e-15 Pulmonary function; BRCA cis rs7766436 0.885 rs13200219 chr6:22595428 C/T cg13666174 chr6:22585274 NA -0.45 -9.69 -0.36 8.56e-21 Coronary artery disease; BRCA cis rs4803468 1.000 rs284656 chr19:41929251 T/C cg09537434 chr19:41945824 ATP5SL -1.0 -23.23 -0.68 5.32e-87 Height; BRCA cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg18404041 chr3:52824283 ITIH1 -0.34 -9.01 -0.34 2.38e-18 Schizophrenia; BRCA cis rs9815354 0.812 rs17214987 chr3:41810481 C/T cg03022575 chr3:42003672 ULK4 -0.72 -9.84 -0.36 2.22e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg12436631 chr1:155007014 DCST1;DCST2 0.27 8.43 0.32 2.27e-16 Prostate cancer; BRCA cis rs586533 0.881 rs646017 chr11:99497150 T/G cg22878054 chr11:99397252 CNTN5 0.32 8.02 0.3 5.08e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs1707322 0.927 rs6690386 chr1:46253011 C/T cg03146154 chr1:46216737 IPP 0.52 11.55 0.42 3.78e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9814567 0.806 rs4955534 chr3:134319723 T/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7586879 0.681 rs6752483 chr2:25120086 C/T cg01884057 chr2:25150051 NA 0.34 9.0 0.34 2.66e-18 Body mass index; BRCA cis rs10876993 0.855 rs1689585 chr12:58080140 A/G cg18357645 chr12:58087776 OS9 -0.47 -13.43 -0.47 2.1e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs769267 0.930 rs4808957 chr19:19567248 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.35 0.35 1.49e-19 Tonsillectomy; BRCA cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA trans rs3780486 0.846 rs10113903 chr9:33122645 C/G cg20290983 chr6:43655470 MRPS18A -1.09 -38.59 -0.84 4.08e-169 IgG glycosylation; BRCA cis rs1468333 1.000 rs13356202 chr5:137564588 G/A cg27119451 chr5:137514611 BRD8;KIF20A 0.43 8.26 0.31 8.61e-16 Resting heart rate; BRCA cis rs6785206 0.730 rs9861429 chr3:128425749 A/G cg16766828 chr3:128327626 NA -0.6 -9.18 -0.34 6e-19 Lymphocyte percentage of white cells; BRCA cis rs1150668 0.796 rs2247002 chr6:28397951 G/C cg14547644 chr6:28411285 ZSCAN23 -0.35 -7.83 -0.3 2e-14 Pubertal anthropometrics; BRCA cis rs13256369 1.000 rs12550762 chr8:8576535 T/A cg18904891 chr8:8559673 CLDN23 0.6 11.92 0.43 1.05e-29 Obesity-related traits; BRCA cis rs965469 0.947 rs4611719 chr20:3228423 G/A cg25506879 chr20:3388711 C20orf194 -0.54 -10.33 -0.38 3.02e-23 IFN-related cytopenia; BRCA cis rs9393692 0.905 rs989134 chr6:26336224 A/C cg13736514 chr6:26305472 NA -0.35 -11.68 -0.42 1.08e-28 Educational attainment; BRCA cis rs12367572 0.965 rs11182706 chr12:45223339 T/C cg04608330 chr12:45269318 NELL2 -0.61 -12.81 -0.45 1.39e-33 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs36028444 chr4:98968635 G/T cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.64e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 9.09 0.34 1.19e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10267417 0.603 rs28770193 chr7:19860804 A/T cg05791153 chr7:19748676 TWISTNB 0.48 9.4 0.35 9.26e-20 Night sleep phenotypes; BRCA cis rs72772090 0.710 rs17400741 chr5:96066576 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.7 -0.45 4.13e-33 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs35995292 0.500 rs28369620 chr7:38921872 C/T cg19327137 chr7:38886074 VPS41 0.38 12.68 0.45 4.91e-33 Subjective well-being (multi-trait analysis); BRCA cis rs2404602 0.716 rs2164101 chr15:76749117 A/G cg23625390 chr15:77176239 SCAPER 0.39 9.06 0.34 1.56e-18 Blood metabolite levels; BRCA cis rs6582630 0.638 rs10880644 chr12:38554959 G/A cg26384229 chr12:38710491 ALG10B 0.43 10.42 0.38 1.38e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs12220238 0.908 rs11000937 chr10:75998785 A/C cg19889307 chr10:75911429 ADK;AP3M1 0.5 8.33 0.31 5.03e-16 Soluble interleukin-2 receptor subunit alpha; BRCA cis rs8017423 1.000 rs8015379 chr14:90679432 C/T cg04374321 chr14:90722782 PSMC1 0.73 19.14 0.6 6.5e-65 Mortality in heart failure; BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg24642844 chr7:1081250 C7orf50 -0.59 -11.55 -0.42 3.6e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.874 rs12509054 chr4:120115075 A/C cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.8e-24 Corneal astigmatism; BRCA cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg00750074 chr16:89608354 SPG7 -0.39 -10.4 -0.38 1.67e-23 Multiple myeloma (IgH translocation); BRCA cis rs312274 0.569 rs11178848 chr12:41266263 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -9.0 -0.34 2.59e-18 Metabolite levels (X-11787); BRCA cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg26944245 chr16:421049 TMEM8A;MRPL28 0.41 9.1 0.34 1.1e-18 Bone mineral density (spine);Bone mineral density; BRCA trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg03929089 chr4:120376271 NA -0.69 -13.73 -0.48 8.73e-38 Height; BRCA cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg18132916 chr6:79620363 NA -0.48 -10.88 -0.4 2.04e-25 Intelligence (multi-trait analysis); BRCA cis rs1712517 0.771 rs7921655 chr10:105113701 C/T cg05636881 chr10:105038444 INA 0.36 7.96 0.3 7.99e-15 Migraine; BRCA cis rs1005277 0.579 rs2800485 chr10:38542588 G/A cg00409905 chr10:38381863 ZNF37A -0.53 -11.29 -0.41 4.26e-27 Extrinsic epigenetic age acceleration; BRCA cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs897984 0.568 rs72799330 chr16:30893555 C/A cg00531865 chr16:30841666 NA -0.38 -7.83 -0.3 2.02e-14 Dementia with Lewy bodies; BRCA cis rs4819052 0.765 rs2838852 chr21:46677037 C/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 13.98 0.48 5.93e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 0.789 rs35729895 chr7:1885069 C/T cg14004847 chr7:1930337 MAD1L1 -0.41 -8.23 -0.31 1.07e-15 Bipolar disorder and schizophrenia; BRCA cis rs6088580 0.634 rs6058041 chr20:33018008 A/G cg24642439 chr20:33292090 TP53INP2 0.52 11.5 0.41 6.16e-28 Glomerular filtration rate (creatinine); BRCA cis rs12188164 0.610 rs6555242 chr5:416546 A/C cg16584290 chr5:462447 EXOC3 -0.38 -9.19 -0.34 5.42e-19 Cystic fibrosis severity; BRCA cis rs9649465 1.000 rs10228367 chr7:123370903 C/T cg04330084 chr7:123175371 IQUB -0.31 -8.64 -0.32 4.49e-17 Migraine; BRCA cis rs9790314 0.586 rs11710086 chr3:161125858 A/T cg04691961 chr3:161091175 C3orf57 -0.39 -9.03 -0.34 1.99e-18 Morning vs. evening chronotype; BRCA cis rs7772486 0.875 rs7761033 chr6:146356106 C/T cg23711669 chr6:146136114 FBXO30 0.73 17.14 0.56 1.74e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs6540559 0.611 rs6540563 chr1:210019858 C/G cg22029157 chr1:209979665 IRF6 0.44 8.33 0.31 4.95e-16 Cleft lip with or without cleft palate; BRCA cis rs4660306 1.000 rs6667191 chr1:45982844 A/G cg24296786 chr1:45957014 TESK2 0.43 8.49 0.32 1.45e-16 Homocysteine levels; BRCA cis rs921968 0.541 rs41461846 chr2:219313354 A/G cg10223061 chr2:219282414 VIL1 0.29 8.26 0.31 8.21e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs7666738 0.830 rs28887893 chr4:98963006 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg17509989 chr5:176798049 RGS14 0.68 13.26 0.46 1.27e-35 Hemoglobin concentration;Hematocrit; BRCA cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg23888215 chr10:79422304 NA -0.56 -10.46 -0.38 9.69e-24 Bone mineral density; BRCA cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg05472934 chr7:22766657 IL6 0.52 13.31 0.47 7.36e-36 Lung cancer; BRCA cis rs4481887 0.962 rs4244177 chr1:248468279 C/T cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA cis rs9368481 0.672 rs3931463 chr6:26939797 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.2 0.31 1.28e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs12310956 0.532 rs1525903 chr12:33964163 T/C cg06521331 chr12:34319734 NA -0.57 -11.13 -0.4 1.93e-26 Morning vs. evening chronotype; BRCA cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 0.34 8.25 0.31 9.12e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg08061076 chr7:1943177 MAD1L1 -0.37 -7.81 -0.3 2.28e-14 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg26597838 chr10:835615 NA 0.81 14.51 0.5 1.97e-41 Eosinophil percentage of granulocytes; BRCA cis rs7715806 0.500 rs72633983 chr5:75002845 C/T cg19683494 chr5:74908142 NA 0.5 8.06 0.3 3.69e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg19717773 chr7:2847554 GNA12 -0.43 -9.62 -0.36 1.47e-20 Height; BRCA cis rs9467773 0.620 rs2101581 chr6:26622769 G/T cg09904177 chr6:26538194 HMGN4 0.47 14.72 0.5 1.97e-42 Intelligence (multi-trait analysis); BRCA cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg06221963 chr1:154839813 KCNN3 0.53 14.08 0.49 2.17e-39 Prostate cancer; BRCA trans rs11088226 0.681 rs11700671 chr21:33938621 T/A cg09050820 chr6:167586206 TCP10L2 0.77 13.24 0.46 1.49e-35 Gastritis; BRCA trans rs9329221 0.527 rs7833781 chr8:10333477 A/G cg15556689 chr8:8085844 FLJ10661 0.34 8.6 0.32 5.99e-17 Neuroticism; BRCA cis rs875971 0.597 rs11763224 chr7:65983615 G/T cg11764359 chr7:65958608 NA 0.65 11.51 0.41 5.31e-28 Aortic root size; BRCA cis rs769267 0.896 rs10405625 chr19:19579046 T/G cg03709012 chr19:19516395 GATAD2A 0.81 18.91 0.6 1.2e-63 Tonsillectomy; BRCA cis rs4812048 0.649 rs6100319 chr20:57626568 A/C cg14073986 chr20:57617431 SLMO2 0.77 11.9 0.43 1.22e-29 Mean platelet volume; BRCA cis rs9300255 0.722 rs12304248 chr12:123810425 C/T cg00376283 chr12:123451042 ABCB9 -0.49 -11.27 -0.41 5.3e-27 Neutrophil percentage of white cells; BRCA cis rs801193 0.569 rs35070132 chr7:66238083 C/T cg11764359 chr7:65958608 NA 0.71 15.49 0.52 3.29e-46 Aortic root size; BRCA cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -8.94 -0.33 4.23e-18 Developmental language disorder (linguistic errors); BRCA cis rs6860806 0.661 rs6890009 chr5:131580033 G/T cg11843238 chr5:131593191 PDLIM4 0.33 8.57 0.32 8e-17 Breast cancer; BRCA cis rs11229555 0.645 rs11530830 chr11:58252992 C/G cg15696309 chr11:58395628 NA 0.52 10.93 0.4 1.28e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1595825 0.945 rs1518369 chr2:198859183 C/T cg19156104 chr2:198669113 PLCL1 -0.45 -8.32 -0.31 5.51e-16 Ulcerative colitis; BRCA cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg14440974 chr22:39074834 NA 0.38 8.33 0.31 5.09e-16 Menopause (age at onset); BRCA cis rs1865721 0.771 rs7228890 chr18:73137492 C/A cg26385618 chr18:73139727 C18orf62 -0.44 -10.69 -0.39 1.24e-24 Intelligence; BRCA cis rs9462027 0.628 rs2814968 chr6:34713138 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 2e-14 Systemic lupus erythematosus; BRCA cis rs13392177 0.684 rs62185965 chr2:219073779 T/C cg00012203 chr2:219082015 ARPC2 -0.51 -10.46 -0.38 9.84e-24 Pyoderma gangrenosum in inflammatory bowel disease; BRCA trans rs1814175 0.527 rs10769595 chr11:49638212 A/G cg15704280 chr7:45808275 SEPT13 -0.71 -14.61 -0.5 6.51e-42 Height; BRCA cis rs7945705 0.846 rs2742540 chr11:8899528 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 12.01 0.43 4.31e-30 Hemoglobin concentration; BRCA trans rs629535 0.814 rs72654071 chr8:70079484 A/G cg21567404 chr3:27674614 NA -1.01 -21.77 -0.65 5.17e-79 Dupuytren's disease; BRCA trans rs11098499 0.954 rs17005535 chr4:120411562 C/T cg25214090 chr10:38739885 LOC399744 0.55 12.55 0.44 1.83e-32 Corneal astigmatism; BRCA cis rs9467773 1.000 rs1884946 chr6:26545308 C/G cg09904177 chr6:26538194 HMGN4 0.56 18.47 0.59 2.43e-61 Intelligence (multi-trait analysis); BRCA cis rs1775715 0.737 rs11817598 chr10:32206259 A/G cg14930904 chr10:32216787 ARHGAP12 0.34 7.85 0.3 1.72e-14 Bipolar disorder with mood-incongruent psychosis; BRCA cis rs11874712 1.000 rs1800636 chr18:43670420 C/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs2075371 0.932 rs2544215 chr7:133987896 T/C cg20476274 chr7:133979776 SLC35B4 0.7 21.34 0.65 1.05e-76 Mean platelet volume; BRCA cis rs7267979 1.000 rs13038834 chr20:25441433 C/T cg08601574 chr20:25228251 PYGB 0.36 8.34 0.31 4.66e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10501293 0.828 rs17497596 chr11:43102898 A/G cg03447554 chr11:43094025 NA 0.44 8.37 0.31 3.71e-16 Cognitive performance; BRCA cis rs7520050 0.931 rs11211213 chr1:46342517 G/A cg24296786 chr1:45957014 TESK2 0.44 9.89 0.36 1.5e-21 Red blood cell count;Reticulocyte count; BRCA trans rs9929218 1.000 rs4500718 chr16:68754312 A/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.79 -15.59 -0.52 1.15e-46 Colorectal cancer; BRCA cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.09e-23 Motion sickness; BRCA cis rs736801 0.808 rs72797306 chr5:131800750 G/C cg07395648 chr5:131743802 NA -0.38 -8.8 -0.33 1.28e-17 Breast cancer;Mosquito bite size; BRCA cis rs11679072 1.000 rs13410440 chr2:240447304 C/T cg03276489 chr2:240449683 NA 0.53 7.82 0.3 2.18e-14 Blood pressure (smoking interaction); BRCA cis rs17092148 1.000 rs6058112 chr20:33322006 G/C cg16810054 chr20:33298113 TP53INP2 -0.51 -11.37 -0.41 2.13e-27 Neuroticism; BRCA cis rs7918232 0.662 rs10764662 chr10:27300643 T/A cg14442939 chr10:27389572 ANKRD26 0.53 9.14 0.34 8.03e-19 Breast cancer; BRCA cis rs6840258 0.825 rs79998318 chr4:87954166 A/G cg08197287 chr4:87952173 AFF1 -0.44 -8.77 -0.33 1.61e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg08219700 chr8:58056026 NA 0.54 8.85 0.33 8.66e-18 Developmental language disorder (linguistic errors); BRCA cis rs2070997 0.667 rs7869508 chr9:133716802 T/C cg11464064 chr9:133710261 ABL1 0.53 9.6 0.35 1.81e-20 Response to amphetamines; BRCA trans rs61931739 0.500 rs7963282 chr12:34535255 A/C cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs10050465 chr5:93349963 C/A cg25358565 chr5:93447407 FAM172A 1.21 18.73 0.6 1.05e-62 Diabetic retinopathy; BRCA cis rs3806843 0.735 rs813897 chr5:140070029 T/C cg26395211 chr5:140044315 WDR55 0.37 8.52 0.32 1.16e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs3760982 0.565 rs8104300 chr19:44293144 T/C cg12072164 chr19:44306565 LYPD5 0.36 8.6 0.32 5.99e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs7552404 0.924 rs1146579 chr1:76209792 C/T cg03433033 chr1:76189801 ACADM -0.71 -18.22 -0.58 4.72e-60 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs812925 0.512 rs1177309 chr2:61385248 A/G cg15711740 chr2:61764176 XPO1 -0.32 -8.02 -0.3 4.96e-15 Immature fraction of reticulocytes; BRCA cis rs3125734 0.633 rs10761616 chr10:64009076 G/A cg09941381 chr10:64027924 RTKN2 -0.29 -8.21 -0.31 1.24e-15 Rheumatoid arthritis; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg15112475 chr7:1198522 ZFAND2A -0.39 -9.14 -0.34 8.46e-19 Longevity;Endometriosis; BRCA trans rs8002861 0.935 rs1373903 chr13:44475514 G/T cg17145862 chr1:211918768 LPGAT1 0.69 18.14 0.58 1.25e-59 Leprosy; BRCA cis rs1210638 0.706 rs2518798 chr22:18970403 T/C cg09619624 chr22:18985632 NA 0.34 8.08 0.3 3.27e-15 Response to serotonin reuptake inhibitors in major depressive disorder; BRCA cis rs9733 0.596 rs1136808 chr1:150702717 G/C cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs780096 0.546 rs715326 chr2:27725761 A/G cg21248554 chr2:27665150 KRTCAP3 0.32 8.43 0.32 2.34e-16 Total body bone mineral density; BRCA trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.15 -0.37 1.56e-22 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.898 rs72782138 chr2:24048162 T/C cg20701182 chr2:24300061 SF3B14 0.58 9.11 0.34 1.04e-18 Lymphocyte counts; BRCA cis rs2070433 1.000 rs2070433 chr21:47961386 G/A cg05998816 chr21:47859926 PCNT 0.36 8.5 0.32 1.38e-16 Lymphocyte counts; BRCA cis rs8028182 0.501 rs7166281 chr15:75928192 G/T cg20655648 chr15:75932815 IMP3 -0.48 -9.57 -0.35 2.21e-20 Sudden cardiac arrest; BRCA cis rs1059312 0.808 rs10847693 chr12:129292006 G/A cg09035930 chr12:129282057 SLC15A4 0.5 13.98 0.48 6.25e-39 Systemic lupus erythematosus; BRCA trans rs7618501 0.633 rs2008877 chr3:50162291 T/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.23 -0.34 3.84e-19 Intelligence (multi-trait analysis); BRCA cis rs9400271 0.632 rs6930844 chr6:109590286 C/A cg01475377 chr6:109611718 NA -0.43 -10.34 -0.38 2.9e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs72781680 0.898 rs72782113 chr2:24024952 G/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs4555082 0.874 rs28822720 chr14:105746282 T/C cg27165867 chr14:105738592 BRF1 -0.38 -8.85 -0.33 8.51e-18 Mean platelet volume;Platelet distribution width; BRCA cis rs13108904 0.517 rs4974551 chr4:1336410 C/A cg22903657 chr4:1355424 KIAA1530 -0.36 -8.13 -0.31 2.25e-15 Obesity-related traits; BRCA trans rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05039488 chr6:79577232 IRAK1BP1 0.36 8.23 0.31 1.04e-15 Endometrial cancer; BRCA cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.46 0.35 5.8e-20 Motion sickness; BRCA trans rs11098499 0.955 rs35916640 chr4:120155852 T/C cg25214090 chr10:38739885 LOC399744 0.51 10.99 0.4 7.57e-26 Corneal astigmatism; BRCA cis rs992157 0.560 rs6436047 chr2:219108913 A/C cg00012203 chr2:219082015 ARPC2 0.56 11.9 0.43 1.27e-29 Colorectal cancer; BRCA cis rs7666738 0.791 rs34088022 chr4:99001508 G/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs617791 0.530 rs55947178 chr11:65754230 G/A cg17712092 chr4:129076599 LARP1B -0.5 -10.89 -0.4 1.83e-25 Breast cancer; BRCA cis rs9811920 0.609 rs793501 chr3:99591638 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA trans rs7395662 0.504 rs2019666 chr11:48437729 C/T cg03929089 chr4:120376271 NA -0.44 -8.25 -0.31 8.77e-16 HDL cholesterol; BRCA cis rs933688 1.000 rs11948075 chr5:90680579 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 18.9 0.6 1.21e-63 Smoking behavior; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg16145915 chr7:1198662 ZFAND2A -0.65 -15.85 -0.53 6.11e-48 Longevity;Endometriosis; BRCA cis rs6088590 0.965 rs6087619 chr20:33288511 C/G cg06115741 chr20:33292138 TP53INP2 0.51 11.22 0.41 8.49e-27 Coronary artery disease; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg00149659 chr3:10157352 C3orf10 0.8 13.73 0.48 9.11e-38 Alzheimer's disease; BRCA cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.22 0.49 4.42e-40 Motion sickness; BRCA cis rs12545109 0.959 rs12546307 chr8:57314790 T/A cg09654669 chr8:57350985 NA -0.39 -8.1 -0.31 2.86e-15 Obesity-related traits; BRCA cis rs6964587 0.626 rs4729014 chr7:91550707 A/G cg17063962 chr7:91808500 NA -0.56 -12.82 -0.45 1.23e-33 Breast cancer; BRCA cis rs10193935 1.000 rs13391906 chr2:42538617 C/G cg27598129 chr2:42591480 NA -0.96 -14.93 -0.51 1.87e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg01802117 chr1:53393560 SCP2 0.34 7.86 0.3 1.67e-14 Monocyte count; BRCA cis rs13046373 0.535 rs1961167 chr21:32030310 T/C cg22337977 chr21:31811175 KRTAP15-1 0.34 7.83 0.3 2.09e-14 HDL cholesterol; BRCA cis rs365132 0.875 rs353491 chr5:176432947 C/G cg16309518 chr5:176445507 NA -0.41 -9.82 -0.36 2.63e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2075371 1.000 rs2058976 chr7:133981379 G/T cg02659138 chr7:134003124 SLC35B4 0.33 10.22 0.37 7.85e-23 Mean platelet volume; BRCA cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg27279351 chr12:120934652 DYNLL1 0.57 13.38 0.47 3.5e-36 High light scatter reticulocyte count; BRCA trans rs6461049 0.765 rs4719432 chr7:2140330 A/G cg04565464 chr8:145669602 NFKBIL2 0.4 9.73 0.36 5.71e-21 Schizophrenia; BRCA cis rs898097 0.691 rs7222773 chr17:80907283 A/G cg15664640 chr17:80829946 TBCD 0.43 11.64 0.42 1.49e-28 Breast cancer; BRCA cis rs4919694 1.000 rs10509758 chr10:104681710 T/C cg04362960 chr10:104952993 NT5C2 0.93 14.99 0.51 9.22e-44 Arsenic metabolism; BRCA cis rs780096 0.526 rs13391837 chr2:27649375 A/G cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.33 -0.31 4.93e-16 Total body bone mineral density; BRCA cis rs17253792 0.822 rs13379353 chr14:56050478 G/C cg01858014 chr14:56050164 KTN1 -0.77 -11.27 -0.41 5.52e-27 Putamen volume; BRCA cis rs1707322 0.963 rs4660900 chr1:46419605 T/C cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.27e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1511802 0.579 rs7682918 chr4:187115841 C/T cg24794857 chr4:187113578 CYP4V2 0.37 7.86 0.3 1.65e-14 Blood protein levels; BRCA cis rs896854 0.552 rs2515236 chr8:95934907 A/G cg16049864 chr8:95962084 TP53INP1 0.39 8.36 0.31 3.99e-16 Type 2 diabetes; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Total body bone mineral density; BRCA cis rs875971 0.929 rs778682 chr7:65837934 A/G cg11764359 chr7:65958608 NA 0.8 19.53 0.61 6.05e-67 Aortic root size; BRCA cis rs858239 0.539 rs10247268 chr7:23187179 G/A cg23682824 chr7:23144976 KLHL7 0.37 9.64 0.36 1.27e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs12971120 0.685 rs34780792 chr18:72173278 G/A cg25817165 chr18:72167213 CNDP2 -0.75 -13.59 -0.47 3.72e-37 Refractive error; BRCA cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg24977027 chr2:88469347 THNSL2 0.47 8.03 0.3 4.81e-15 Plasma clusterin levels; BRCA cis rs4927850 0.501 rs9881504 chr3:195656614 A/G cg12923728 chr3:195709715 SDHAP1 -0.47 -8.94 -0.33 4.14e-18 Pancreatic cancer; BRCA cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.26 0.44 3.37e-31 Lung cancer in ever smokers; BRCA cis rs16976116 0.901 rs28508034 chr15:55499010 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9381040 0.610 rs2235678 chr6:41020510 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.99 -0.34 2.68e-18 Alzheimer's disease (late onset); BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs9926296 0.618 rs8058179 chr16:89846987 C/T cg04287289 chr16:89883240 FANCA -0.59 -13.38 -0.47 3.66e-36 Vitiligo; BRCA cis rs7666738 0.512 rs6532704 chr4:98777562 C/T cg05340658 chr4:99064831 C4orf37 0.44 10.14 0.37 1.74e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs637571 0.522 rs542332 chr11:65744421 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 10.12 0.37 2.02e-22 Eosinophil percentage of white cells; BRCA cis rs798554 0.679 rs1636253 chr7:2885123 A/G cg14863265 chr7:2801509 GNA12 -0.45 -9.98 -0.37 6.92e-22 Height; BRCA cis rs769267 0.896 rs11882123 chr19:19386339 A/G cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.71e-14 Tonsillectomy; BRCA cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg22800045 chr5:56110881 MAP3K1 0.56 10.52 0.38 5.82e-24 Initial pursuit acceleration; BRCA cis rs10046574 0.831 rs10243569 chr7:135063466 G/A cg27474649 chr7:135195673 CNOT4 0.58 8.3 0.31 6.41e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9814567 1.000 rs6772896 chr3:134203347 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -19.43 -0.61 2.06e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7312933 0.584 rs6582391 chr12:42634686 G/A cg01256987 chr12:42539512 GXYLT1 -0.42 -8.31 -0.31 5.95e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1468333 0.724 rs7726580 chr5:137608666 A/G cg27119451 chr5:137514611 BRD8;KIF20A -0.38 -7.95 -0.3 8.21e-15 Resting heart rate; BRCA cis rs6570726 0.935 rs384519 chr6:145846017 C/A cg23711669 chr6:146136114 FBXO30 0.65 15.25 0.52 5.11e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs13122456 chr4:98936011 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6866344 0.570 rs1132336 chr5:178140090 C/T cg10224037 chr5:178157518 ZNF354A 0.78 17.8 0.58 7.13e-58 Neutrophil percentage of white cells; BRCA cis rs2652834 0.904 rs2729826 chr15:63360446 C/G cg05507819 chr15:63340323 TPM1 -0.48 -8.77 -0.33 1.58e-17 HDL cholesterol; BRCA cis rs1005277 0.563 rs2505215 chr10:38481273 A/G cg25427524 chr10:38739819 LOC399744 -0.73 -18.04 -0.58 4.15e-59 Extrinsic epigenetic age acceleration; BRCA cis rs3806843 0.676 rs1583005 chr5:140031537 G/A cg16179182 chr5:140090404 VTRNA1-1 0.47 10.87 0.39 2.34e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs483180 0.512 rs612430 chr1:120216025 A/G cg19096424 chr1:120255104 PHGDH 0.43 9.54 0.35 2.85e-20 Macular telangiectasia type 2; BRCA cis rs12586317 0.620 rs17103042 chr14:35575428 T/C cg16230307 chr14:35515116 FAM177A1 0.69 14.27 0.49 2.52e-40 Psoriasis; BRCA cis rs6582630 0.537 rs11611326 chr12:38547958 C/A cg26384229 chr12:38710491 ALG10B 0.77 17.76 0.57 1.24e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs1215050 0.791 rs783969 chr4:98906504 C/T cg05340658 chr4:99064831 C4orf37 0.41 8.7 0.33 2.88e-17 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.1 0.49 1.66e-39 Personality dimensions; BRCA cis rs9611565 0.659 rs12484228 chr22:41939739 A/G cg06634786 chr22:41940651 POLR3H -0.59 -10.44 -0.38 1.12e-23 Vitiligo; BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA trans rs561341 1.000 rs72823787 chr17:30283809 A/T cg20587970 chr11:113659929 NA -1.34 -24.49 -0.7 6.49e-94 Hip circumference adjusted for BMI; BRCA cis rs13108904 0.935 rs2293633 chr4:1291640 T/C cg05665937 chr4:1216051 CTBP1 0.39 8.47 0.32 1.66e-16 Obesity-related traits; BRCA trans rs7615952 0.599 rs6438953 chr3:125724951 T/C cg07211511 chr3:129823064 LOC729375 -0.6 -11.53 -0.41 4.5e-28 Blood pressure (smoking interaction); BRCA cis rs367943 1.000 rs348952 chr5:112821990 G/T cg12552261 chr5:112820674 MCC -0.55 -12.11 -0.43 1.59e-30 Type 2 diabetes; BRCA cis rs4494114 1.000 rs4388668 chr1:39360730 A/T cg25970120 chr1:39325951 RRAGC -0.37 -7.91 -0.3 1.11e-14 Blood protein levels; BRCA cis rs1801251 0.778 rs2592116 chr2:233735709 G/A cg08000102 chr2:233561755 GIGYF2 -0.46 -9.97 -0.37 7.41e-22 Coronary artery disease; BRCA cis rs7829975 0.606 rs11776838 chr8:8794801 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -11.34 -0.41 2.88e-27 Mood instability; BRCA trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21659725 chr3:3221576 CRBN -0.47 -12.18 -0.43 7.65e-31 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg01262667 chr19:19385393 TM6SF2 0.43 11.09 0.4 2.97e-26 Tonsillectomy; BRCA cis rs832540 0.864 rs832576 chr5:56163255 C/A cg24531977 chr5:56204891 C5orf35 -0.4 -8.59 -0.32 6.77e-17 Coronary artery disease; BRCA cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg18225595 chr11:63971243 STIP1 0.53 9.39 0.35 1.05e-19 Mean platelet volume; BRCA cis rs17401966 0.931 rs1555849 chr1:10400602 G/T cg19773385 chr1:10388646 KIF1B 0.38 8.44 0.32 2.18e-16 Hepatocellular carcinoma; BRCA cis rs910316 1.000 rs3742778 chr14:75538217 A/C cg08847533 chr14:75593920 NEK9 -0.94 -24.98 -0.7 1.27e-96 Height; BRCA cis rs11690935 0.959 rs973889 chr2:172579954 A/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.47 -0.77 1.31e-126 Schizophrenia; BRCA cis rs57221529 0.709 rs72706611 chr5:561146 C/A cg09021430 chr5:549028 NA -0.69 -15.85 -0.53 5.74e-48 Lung disease severity in cystic fibrosis; BRCA cis rs7659604 0.592 rs56077950 chr4:122721412 C/T cg06713675 chr4:122721982 EXOSC9 -0.54 -12.51 -0.44 2.87e-32 Type 2 diabetes; BRCA cis rs6089829 0.962 rs9680064 chr20:61666168 G/A cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs2832077 0.527 rs59730679 chr21:30226244 T/C cg08807101 chr21:30365312 RNF160 -0.55 -12.4 -0.44 8.38e-32 Cognitive test performance; BRCA cis rs4953076 0.573 rs9973609 chr2:44450435 T/C cg04920474 chr2:44395004 PPM1B 0.49 9.67 0.36 9.47e-21 Height; BRCA cis rs853679 0.542 rs9393892 chr6:28081394 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.22 -0.31 1.13e-15 Depression; BRCA cis rs6138458 0.546 rs6050118 chr20:24891895 C/T cg26195577 chr20:24973756 C20orf3 -0.74 -11.07 -0.4 3.66e-26 Blood protein levels; BRCA cis rs9527 1.000 rs4919690 chr10:104616500 C/T cg04362960 chr10:104952993 NT5C2 -0.51 -10.66 -0.39 1.56e-24 Arsenic metabolism; BRCA cis rs708547 0.836 rs1315005 chr4:57858237 C/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -10.73 -0.39 8.08e-25 Response to bleomycin (chromatid breaks); BRCA trans rs1945213 0.659 rs11227133 chr11:55836620 T/C cg03929089 chr4:120376271 NA 0.6 10.37 0.38 2.13e-23 Acute lymphoblastic leukemia (childhood); BRCA trans rs7824557 0.527 rs2409756 chr8:11242025 A/C cg06636001 chr8:8085503 FLJ10661 -0.44 -9.16 -0.34 7.23e-19 Retinal vascular caliber; BRCA cis rs2479724 0.901 rs33954419 chr6:41786136 A/G cg17623882 chr6:41773611 USP49 -0.36 -9.97 -0.37 7.26e-22 Menarche (age at onset); BRCA cis rs4665809 0.590 rs962217 chr2:26438276 T/C cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs611744 0.608 rs667742 chr8:109254003 T/C cg21045802 chr8:109455806 TTC35 0.35 8.02 0.3 5.19e-15 Dupuytren's disease; BRCA cis rs3733585 0.579 rs4235356 chr4:10123106 G/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.1 -0.37 2.28e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs916888 0.773 rs9896243 chr17:44826056 C/G cg19987790 chr17:43696684 MGC57346 -0.52 -9.25 -0.34 3.31e-19 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs9660992 0.710 rs1768586 chr1:205238275 A/G cg00857998 chr1:205179979 DSTYK 0.42 8.15 0.31 1.98e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs4481887 0.962 rs12037921 chr1:248454167 T/G cg00666640 chr1:248458726 OR2T12 0.31 8.31 0.31 5.74e-16 Common traits (Other); BRCA cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg22974920 chr21:40686053 BRWD1 -0.35 -7.87 -0.3 1.51e-14 Menarche (age at onset); BRCA cis rs473651 0.901 rs563282 chr2:239329736 T/C cg03560586 chr2:239334908 ASB1 -0.38 -8.0 -0.3 5.72e-15 Multiple system atrophy; BRCA cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg11058730 chr11:34937778 PDHX;APIP 0.71 16.82 0.55 7.74e-53 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs1215050 0.755 rs7696354 chr4:98820330 T/C cg05340658 chr4:99064831 C4orf37 0.42 8.9 0.33 5.58e-18 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2576037 0.583 rs501062 chr18:44411135 C/T cg19077165 chr18:44547161 KATNAL2 -0.58 -13.02 -0.46 1.57e-34 Personality dimensions; BRCA cis rs12760731 0.720 rs722321 chr1:178420220 C/T cg00404053 chr1:178313656 RASAL2 0.67 8.31 0.31 5.57e-16 Obesity-related traits; BRCA cis rs6547741 1.000 rs2384654 chr2:27847364 C/T cg27432699 chr2:27873401 GPN1 0.42 8.93 0.33 4.38e-18 Oral cavity cancer; BRCA cis rs3796352 1.000 rs11707780 chr3:53084326 A/G cg07884673 chr3:53033167 SFMBT1 -0.58 -8.75 -0.33 1.9e-17 Immune reponse to smallpox (secreted IL-2); BRCA cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg12641515 chr19:46296257 DMWD -0.53 -11.83 -0.42 2.39e-29 Coronary artery disease; BRCA cis rs265548 0.646 rs36689 chr19:17910639 A/G cg16744531 chr19:17905626 B3GNT3 0.54 11.92 0.43 9.87e-30 Tumor biomarkers; BRCA cis rs66887589 0.934 rs2389873 chr4:120554714 A/G cg09307838 chr4:120376055 NA -0.44 -9.14 -0.34 8.1e-19 Diastolic blood pressure; BRCA cis rs775227 0.574 rs3732809 chr3:113045561 A/G cg18753928 chr3:113234510 CCDC52 -0.54 -9.22 -0.34 4.19e-19 Dental caries; BRCA cis rs3733585 0.673 rs9994937 chr4:9964799 G/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.44 -0.38 1.17e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg18964960 chr10:1102726 WDR37 0.64 8.7 0.33 2.81e-17 Eosinophil percentage of granulocytes; BRCA cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.81 11.22 0.41 8.84e-27 Initial pursuit acceleration; BRCA trans rs3857536 0.813 rs1891599 chr6:66941699 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs7917772 0.536 rs4919667 chr10:104426011 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.57 -14.94 -0.51 1.61e-43 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs939658 0.805 rs34222382 chr15:79440748 C/T cg17916960 chr15:79447300 NA -0.46 -11.55 -0.42 3.8e-28 Refractive error; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 2e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs6951245 1.000 rs79765398 chr7:1073764 A/G cg13565492 chr6:43139072 SRF -0.79 -11.09 -0.4 3.05e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs703842 1.000 rs1875124 chr12:58196802 A/G cg18357645 chr12:58087776 OS9 -0.33 -8.0 -0.3 5.66e-15 Multiple sclerosis; BRCA cis rs2070488 0.932 rs1841776 chr3:38480727 C/T cg24069376 chr3:38537580 EXOG 0.42 12.02 0.43 3.84e-30 Electrocardiographic conduction measures; BRCA cis rs798554 0.704 rs2527684 chr7:2825922 G/T cg19717773 chr7:2847554 GNA12 -0.4 -9.13 -0.34 8.89e-19 Height; BRCA cis rs896854 0.967 rs896853 chr8:95960855 G/C cg13393036 chr8:95962371 TP53INP1 -0.34 -9.34 -0.35 1.58e-19 Type 2 diabetes; BRCA cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg18225595 chr11:63971243 STIP1 0.52 9.46 0.35 6.01e-20 Mean platelet volume; BRCA cis rs7818345 1.000 rs7818345 chr8:19306618 T/C cg11303988 chr8:19266685 CSGALNACT1 0.32 8.42 0.32 2.49e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs9443645 0.775 rs9359359 chr6:79700980 T/C cg11833968 chr6:79620685 NA -0.41 -9.07 -0.34 1.45e-18 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.65 16.27 0.54 4.6e-50 Chronic sinus infection; BRCA trans rs783540 0.843 rs28374463 chr15:83299364 A/C cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.47 -0.32 1.71e-16 Schizophrenia; BRCA cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg12310025 chr6:25882481 NA 0.74 17.89 0.58 2.58e-58 Blood metabolite levels; BRCA cis rs1355223 0.525 rs10836316 chr11:34874295 C/T cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.48 -0.35 4.85e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7267979 0.834 rs6115100 chr20:25225938 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.3 8.43 0.32 2.37e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs4650994 1.000 rs4650993 chr1:178515187 A/G cg05059571 chr16:84539110 KIAA1609 -0.43 -9.77 -0.36 4.24e-21 HDL cholesterol levels;HDL cholesterol; BRCA cis rs68170813 0.559 rs17427158 chr7:106824259 G/T cg02696742 chr7:106810147 HBP1 -0.53 -8.41 -0.32 2.67e-16 Coronary artery disease; BRCA cis rs796364 0.950 rs56155997 chr2:200768491 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.71 -10.41 -0.38 1.5e-23 Schizophrenia; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.76 16.55 0.55 1.86e-51 Lymphocyte counts; BRCA cis rs7666738 0.546 rs28444809 chr4:98916934 C/T cg05340658 chr4:99064831 C4orf37 0.57 11.12 0.4 2.13e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs12210905 0.688 rs12209174 chr6:27443952 G/A cg08851530 chr6:28072375 NA 0.81 7.97 0.3 7.05e-15 Hip circumference adjusted for BMI; BRCA cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs2304069 0.954 rs1962603 chr5:149393006 G/T cg12661370 chr5:149340060 SLC26A2 0.57 8.39 0.32 3.06e-16 HIV-1 control; BRCA cis rs734999 0.870 rs2147905 chr1:2482921 C/T cg20673091 chr1:2541236 MMEL1 -0.34 -8.16 -0.31 1.83e-15 Ulcerative colitis; BRCA cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg15485101 chr11:133734466 NA -0.43 -11.2 -0.41 1.01e-26 Childhood ear infection; BRCA cis rs6912958 0.781 rs9450755 chr6:88303702 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.42 -0.32 2.42e-16 Monocyte percentage of white cells; BRCA cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.4 -0.41 1.57e-27 Electroencephalogram traits; BRCA cis rs11603020 0.950 rs78624400 chr11:57375463 G/C cg19752551 chr11:57585705 CTNND1 -0.41 -9.7 -0.36 7.35e-21 Blood protein levels; BRCA cis rs12586317 0.586 rs74243591 chr14:35520917 C/T cg16230307 chr14:35515116 FAM177A1 0.77 15.42 0.52 7.64e-46 Psoriasis; BRCA cis rs7829975 0.522 rs6601689 chr8:8172283 C/T cg15556689 chr8:8085844 FLJ10661 0.43 12.15 0.43 1.03e-30 Mood instability; BRCA trans rs783540 0.935 rs2278355 chr15:83331155 C/T cg18393722 chr15:85113863 UBE2QP1 0.26 8.03 0.3 4.65e-15 Schizophrenia; BRCA cis rs7131987 0.621 rs11050181 chr12:29467669 C/T cg09582351 chr12:29534625 ERGIC2 -0.43 -9.96 -0.37 8.3e-22 QT interval; BRCA cis rs4727027 0.754 rs11764892 chr7:148858916 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.46 10.13 0.37 1.77e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs11098499 0.604 rs2389882 chr4:120566733 A/C cg09307838 chr4:120376055 NA 0.58 11.03 0.4 5.03e-26 Corneal astigmatism; BRCA cis rs66887589 0.934 rs12648182 chr4:120503891 T/A cg09307838 chr4:120376055 NA -0.44 -9.27 -0.34 2.93e-19 Diastolic blood pressure; BRCA cis rs3845702 0.668 rs6759271 chr2:180844303 T/C cg01881094 chr2:180872142 CWC22 -1.04 -18.5 -0.59 1.71e-61 Schizophrenia; BRCA cis rs2629540 0.889 rs4962699 chr10:126477209 A/G cg08799069 chr10:126477246 METTL10 -0.54 -12.11 -0.43 1.58e-30 Cocaine dependence; BRCA cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg04511125 chr2:88470314 THNSL2 0.8 11.47 0.41 8.04e-28 Plasma clusterin levels; BRCA cis rs7599312 0.963 rs6735267 chr2:213403863 C/T cg16329650 chr2:213403929 ERBB4 0.46 9.75 0.36 5.07e-21 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg27286337 chr10:134555280 INPP5A 0.78 12.76 0.45 2.3e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6809651 0.524 rs6444105 chr3:185811301 C/T cg00760338 chr3:185826511 ETV5 -0.48 -9.56 -0.35 2.57e-20 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.83e-15 Breast cancer; BRCA cis rs6866344 0.697 rs62392832 chr5:178134395 T/C cg03877680 chr5:178157825 ZNF354A 0.77 14.59 0.5 8.19e-42 Neutrophil percentage of white cells; BRCA trans rs5756813 0.661 rs2285177 chr22:38205894 A/G cg19894588 chr14:64061835 NA -0.52 -11.41 -0.41 1.44e-27 Optic cup area;Vertical cup-disc ratio; BRCA cis rs7666738 0.830 rs11727612 chr4:99001662 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6973256 0.897 rs6970448 chr7:133343642 G/A cg07491979 chr7:133331646 EXOC4 -0.39 -9.05 -0.34 1.69e-18 Intelligence (multi-trait analysis); BRCA cis rs807669 0.525 rs9604934 chr22:19194868 C/T cg02655711 chr22:19163373 SLC25A1 0.43 9.99 0.37 6.41e-22 Metabolite levels; BRCA cis rs7927592 0.913 rs12285993 chr11:68302538 A/G cg20283391 chr11:68216788 NA -0.46 -8.99 -0.33 2.87e-18 Total body bone mineral density; BRCA trans rs61931739 0.534 rs1486886 chr12:34043619 C/T cg26384229 chr12:38710491 ALG10B 0.56 12.16 0.43 9.7e-31 Morning vs. evening chronotype; BRCA cis rs68170813 0.559 rs80153759 chr7:106944145 C/A cg02696742 chr7:106810147 HBP1 -0.52 -8.59 -0.32 6.47e-17 Coronary artery disease; BRCA cis rs34779708 0.931 rs17591135 chr10:35465190 T/A cg03585969 chr10:35415529 CREM 0.56 11.62 0.42 1.84e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9291683 0.632 rs11734375 chr4:10046298 A/G cg02734326 chr4:10020555 SLC2A9 0.39 8.28 0.31 7.31e-16 Bone mineral density; BRCA cis rs4713118 0.955 rs9368529 chr6:27684631 G/A cg20933634 chr6:27740509 NA 0.44 8.43 0.32 2.27e-16 Parkinson's disease; BRCA cis rs1865760 0.622 rs9968910 chr6:26072095 A/C cg17691542 chr6:26056736 HIST1H1C 0.66 13.7 0.48 1.19e-37 Height; BRCA trans rs61931739 0.517 rs12815556 chr12:34319670 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.77e-20 Morning vs. evening chronotype; BRCA cis rs1595825 0.891 rs73056859 chr2:198801720 A/G cg19156104 chr2:198669113 PLCL1 -0.45 -8.37 -0.31 3.61e-16 Ulcerative colitis; BRCA cis rs1801251 1.000 rs6717841 chr2:233590255 C/T cg08000102 chr2:233561755 GIGYF2 0.63 13.77 0.48 5.88e-38 Coronary artery disease; BRCA cis rs600806 0.745 rs4970763 chr1:110006349 G/A cg20591472 chr1:110008990 SYPL2 0.31 7.93 0.3 1.01e-14 Intelligence (multi-trait analysis); BRCA cis rs2599510 0.744 rs4952212 chr2:32618493 G/C cg02381751 chr2:32503542 YIPF4 -0.43 -8.51 -0.32 1.27e-16 Interleukin-18 levels; BRCA cis rs897984 0.542 rs11865038 chr16:31095171 C/T cg02466173 chr16:30829666 NA -0.44 -9.79 -0.36 3.39e-21 Dementia with Lewy bodies; BRCA cis rs1865760 0.566 rs2032443 chr6:26046802 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 11.68 0.42 1.06e-28 Height; BRCA cis rs2842992 0.789 rs6908680 chr6:160218209 G/T cg11366901 chr6:160182831 ACAT2 0.82 15.87 0.53 4.47e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs9381040 0.610 rs742495 chr6:41018233 A/G cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.88 -0.36 1.6e-21 Alzheimer's disease (late onset); BRCA cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg07537917 chr2:241836409 C2orf54 0.49 11.62 0.42 1.94e-28 Urinary metabolites; BRCA cis rs2730245 1.000 rs2730245 chr7:158724789 G/C cg14689365 chr7:158441557 NCAPG2 -0.44 -9.05 -0.34 1.78e-18 Height; BRCA cis rs1552244 0.935 rs7649243 chr3:10089470 T/A cg13047869 chr3:10149882 C3orf24 0.59 12.27 0.44 3.13e-31 Alzheimer's disease; BRCA cis rs6495367 1.000 rs1961579 chr15:79380516 G/A cg17916960 chr15:79447300 NA 0.32 8.11 0.31 2.66e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg03116740 chr11:841335 TSPAN4;POLR2L -0.36 -8.13 -0.31 2.18e-15 Mean platelet volume; BRCA cis rs7618915 0.571 rs6762457 chr3:52609157 G/A cg18404041 chr3:52824283 ITIH1 -0.41 -12.07 -0.43 2.3e-30 Bipolar disorder; BRCA cis rs4363385 0.765 rs11205165 chr1:152986928 G/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.19 -0.31 1.42e-15 Inflammatory skin disease; BRCA cis rs1865760 0.865 rs9467652 chr6:25959127 A/G cg16482183 chr6:26056742 HIST1H1C 0.51 10.58 0.39 3.17e-24 Height; BRCA cis rs12368653 0.840 rs10877020 chr12:58188014 G/A cg02175503 chr12:58329896 NA -0.42 -8.97 -0.33 3.13e-18 Multiple sclerosis; BRCA cis rs6088580 0.524 rs6088570 chr20:33268295 T/C cg24642439 chr20:33292090 TP53INP2 -0.43 -8.75 -0.33 1.83e-17 Glomerular filtration rate (creatinine); BRCA cis rs2882667 0.619 rs6861556 chr5:138188040 C/T cg04439458 chr5:138467593 SIL1 0.35 8.58 0.32 7.29e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7914558 0.902 rs3736922 chr10:104850632 A/G cg04362960 chr10:104952993 NT5C2 -0.39 -9.52 -0.35 3.55e-20 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg02951883 chr7:2050386 MAD1L1 -0.5 -11.37 -0.41 2e-27 Bipolar disorder and schizophrenia; BRCA cis rs11190604 1.000 rs3763695 chr10:102269206 A/G cg07080220 chr10:102295463 HIF1AN 0.61 14.56 0.5 1.16e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs798554 1.000 rs798550 chr7:2760609 A/G cg23285459 chr7:2802560 GNA12 -0.34 -8.53 -0.32 1.05e-16 Height; BRCA cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.27 -0.34 2.9e-19 Alzheimer's disease (late onset); BRCA cis rs7703051 0.520 rs13354746 chr5:74619132 C/T cg19683494 chr5:74908142 NA 0.56 9.57 0.35 2.32e-20 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; BRCA cis rs10751667 0.600 rs10902266 chr11:1005697 G/T cg20946044 chr11:1010712 AP2A2 -0.37 -7.87 -0.3 1.56e-14 Alzheimer's disease (late onset); BRCA cis rs637571 0.522 rs679581 chr11:65746653 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.63 14.22 0.49 4.41e-40 Eosinophil percentage of white cells; BRCA cis rs2239547 0.657 rs3755803 chr3:52866157 C/G cg18404041 chr3:52824283 ITIH1 -0.34 -9.11 -0.34 1.05e-18 Schizophrenia; BRCA cis rs72772090 0.522 rs112272517 chr5:95987246 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.56 -8.15 -0.31 1.91e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs875971 0.965 rs10267430 chr7:65743023 G/T cg11764359 chr7:65958608 NA -0.8 -19.58 -0.61 3.16e-67 Aortic root size; BRCA trans rs7613875 0.620 rs3774734 chr3:50108792 C/A cg21659725 chr3:3221576 CRBN -0.33 -7.83 -0.3 2e-14 Body mass index; BRCA cis rs911119 0.913 rs34792920 chr20:23581876 C/T cg16589663 chr20:23618590 CST3 0.45 8.2 0.31 1.35e-15 Chronic kidney disease; BRCA cis rs2011503 1.000 rs1557723 chr19:19443033 A/G cg11584989 chr19:19387371 SF4 -0.59 -13.38 -0.47 3.66e-36 Bipolar disorder; BRCA cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg11890956 chr21:40555474 PSMG1 1.04 28.31 0.75 6.97e-115 Cognitive function; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.35e-19 Tonsillectomy; BRCA cis rs9311474 0.508 rs11718420 chr3:52611413 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.51 0.44 2.88e-32 Electroencephalogram traits; BRCA cis rs6942756 0.513 rs10954224 chr7:128893513 T/A cg02491457 chr7:128862824 NA 0.45 9.53 0.35 3.21e-20 White matter hyperintensity burden; BRCA cis rs4665809 1.000 rs2384321 chr2:26290054 A/G cg25036284 chr2:26402008 FAM59B -0.79 -12.41 -0.44 7.62e-32 Gut microbiome composition (summer); BRCA cis rs2742234 0.590 rs2503848 chr10:43672785 G/A cg02780029 chr10:43622663 RET -0.35 -7.96 -0.3 7.99e-15 Hirschsprung disease; BRCA cis rs1577917 0.958 rs11755048 chr6:86514334 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -8.34 -0.31 4.51e-16 Response to antipsychotic treatment; BRCA cis rs72772090 0.710 rs10515244 chr5:96078337 C/G cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.76 -0.45 2.16e-33 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg22105103 chr4:187893119 NA 0.41 13.33 0.47 5.9e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 1.000 rs4665819 chr2:26309073 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.36 -0.41 2.25e-27 Gut microbiome composition (summer); BRCA trans rs10506458 1.000 rs12425655 chr12:63434463 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.04 -17.32 -0.57 2.31e-55 Hemostatic factors and hematological phenotypes; BRCA cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.88 -0.3 1.39e-14 Colorectal cancer; BRCA cis rs67981189 0.593 rs2877708 chr14:71484126 C/G cg15816911 chr14:71606274 NA 0.37 8.45 0.32 1.98e-16 Schizophrenia; BRCA cis rs10751667 0.666 rs7483273 chr11:951127 T/C cg10932868 chr11:921992 NA 0.48 12.19 0.43 7.02e-31 Alzheimer's disease (late onset); BRCA cis rs12291225 0.679 rs11023172 chr11:14295367 C/G cg19336497 chr11:14380999 RRAS2 -0.48 -11.99 -0.43 4.92e-30 Sense of smell; BRCA cis rs870825 0.616 rs7682557 chr4:185640773 A/G cg04058563 chr4:185651563 MLF1IP 0.77 17.18 0.56 1.08e-54 Blood protein levels; BRCA cis rs1153858 1.000 rs12909158 chr15:45621174 A/G cg21132104 chr15:45694354 SPATA5L1 0.72 15.59 0.53 1.08e-46 Homoarginine levels; BRCA trans rs10242455 0.557 rs45529541 chr7:99048143 C/A cg09045935 chr12:6379348 NA 0.87 9.16 0.34 7.05e-19 Blood metabolite levels; BRCA cis rs877282 0.891 rs11253355 chr10:768367 C/G cg17470449 chr10:769945 NA 0.49 8.52 0.32 1.15e-16 Uric acid levels; BRCA trans rs11098499 0.691 rs17009144 chr4:120270795 C/T cg25214090 chr10:38739885 LOC399744 -0.43 -10.27 -0.38 5.49e-23 Corneal astigmatism; BRCA cis rs2836974 0.897 rs1541102 chr21:40628765 C/T cg11890956 chr21:40555474 PSMG1 1.04 29.48 0.76 3.03e-121 Cognitive function; BRCA cis rs12950390 0.853 rs11079792 chr17:45863311 T/C cg03474202 chr17:45855739 NA -0.45 -11.99 -0.43 4.97e-30 IgG glycosylation; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg03188948 chr7:1209495 NA 0.5 9.4 0.35 9.55e-20 Longevity;Endometriosis; BRCA cis rs6582630 0.537 rs7299661 chr12:38527713 C/T cg26384229 chr12:38710491 ALG10B 0.67 16.24 0.54 6.76e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs17092148 0.652 rs61341205 chr20:33072578 A/G cg16810054 chr20:33298113 TP53INP2 0.43 9.46 0.35 5.64e-20 Neuroticism; BRCA cis rs838147 0.760 rs412712 chr19:49234299 A/T cg12258179 chr19:49232187 RASIP1 0.33 8.24 0.31 9.61e-16 Dietary macronutrient intake; BRCA cis rs6951245 0.554 rs78999139 chr7:1138525 G/A cg24642844 chr7:1081250 C7orf50 -0.56 -11.4 -0.41 1.51e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs60871478 0.636 rs4721834 chr7:896142 C/T cg22972055 chr7:872293 UNC84A 0.39 8.76 0.33 1.68e-17 Cerebrospinal P-tau181p levels; BRCA trans rs6089829 0.925 rs4809270 chr20:61676709 C/A cg17470723 chr8:74884337 TCEB1 0.39 8.13 0.31 2.25e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs61931739 0.513 rs1608908 chr12:33895389 C/A cg26384229 chr12:38710491 ALG10B 0.47 10.83 0.39 3.42e-25 Morning vs. evening chronotype; BRCA trans rs7613875 0.580 rs6808044 chr3:50136165 A/G cg21659725 chr3:3221576 CRBN -0.34 -7.96 -0.3 7.94e-15 Body mass index; BRCA cis rs9287719 0.967 rs6759714 chr2:10747207 A/G cg00105475 chr2:10696890 NA 0.44 10.4 0.38 1.66e-23 Prostate cancer; BRCA cis rs698813 0.763 rs698764 chr2:44573658 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.61 11.75 0.42 5.39e-29 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs6089584 0.566 rs11699442 chr20:60623268 A/G cg06108461 chr20:60628389 TAF4 -0.71 -14.63 -0.5 5.25e-42 Body mass index; BRCA cis rs7312933 0.898 rs10880221 chr12:42384589 C/A cg01256987 chr12:42539512 GXYLT1 -0.56 -11.37 -0.41 2.11e-27 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.02 19.45 0.61 1.49e-66 Platelet count; BRCA cis rs10791323 0.582 rs2723613 chr11:133706696 G/A cg14349672 chr11:133703707 NA -0.43 -9.54 -0.35 2.93e-20 Childhood ear infection; BRCA cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 1.000 rs807931 chr3:47389317 C/T cg27129171 chr3:47204927 SETD2 0.71 17.36 0.57 1.36e-55 Colorectal cancer; BRCA cis rs7666738 0.791 rs11729596 chr4:99045461 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7647973 0.925 rs9881860 chr3:49352522 A/T cg07636037 chr3:49044803 WDR6 0.71 14.21 0.49 5.02e-40 Menarche (age at onset); BRCA cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg22800045 chr5:56110881 MAP3K1 0.65 12.32 0.44 1.9e-31 Initial pursuit acceleration; BRCA cis rs2762353 0.603 rs9393670 chr6:25789061 A/G cg12310025 chr6:25882481 NA 0.4 9.31 0.35 2.01e-19 Blood metabolite levels; BRCA cis rs9457247 1.000 rs416131 chr6:167406544 A/C cg00271210 chr6:167070053 RPS6KA2 0.33 8.8 0.33 1.22e-17 Crohn's disease; BRCA cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.9 -0.4 1.67e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9814567 1.000 rs4367113 chr3:134287975 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.73 -0.33 2.15e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4727027 0.933 rs12704062 chr7:148827865 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.01 0.4 6.48e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2075371 1.000 rs2241335 chr7:133979368 C/T cg20476274 chr7:133979776 SLC35B4 0.65 19.36 0.61 4.76e-66 Mean platelet volume; BRCA cis rs765787 0.530 rs11639403 chr15:45538350 A/G cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg04267008 chr7:1944627 MAD1L1 -0.52 -12.05 -0.43 2.81e-30 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.580 rs1115078 chr6:8449638 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs1997103 0.954 rs4947505 chr7:55409448 T/C cg17469321 chr7:55412551 NA 0.51 9.62 0.36 1.53e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7267979 0.966 rs2261747 chr20:25261784 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.51 0.35 3.79e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs868036 1.000 rs4633663 chr15:68106378 G/C cg05925327 chr15:68127851 NA -0.31 -7.9 -0.3 1.23e-14 Restless legs syndrome; BRCA cis rs7666738 0.830 rs7673880 chr4:99057262 A/G cg05340658 chr4:99064831 C4orf37 0.68 17.09 0.56 3.15e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.959 rs798558 chr7:2758935 T/G cg19346786 chr7:2764209 NA -0.37 -11.1 -0.4 2.57e-26 Height; BRCA cis rs6762477 0.748 rs11717349 chr3:50223977 C/T cg24110177 chr3:50126178 RBM5 0.37 10.05 0.37 3.59e-22 Menarche (age at onset); BRCA cis rs7582180 0.606 rs12618908 chr2:100947026 A/T cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA cis rs11051970 0.879 rs2243815 chr12:32576158 C/T cg24626660 chr12:32551988 NA 0.29 8.16 0.31 1.75e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs78456975 1.000 rs7584264 chr2:1565555 A/G cg12573674 chr2:1569213 NA -0.47 -9.14 -0.34 8.54e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9921222 0.502 rs28461430 chr16:369562 G/A cg00101154 chr16:420108 MRPL28 -0.39 -8.44 -0.32 2.18e-16 Bone mineral density (spine);Bone mineral density; BRCA cis rs769267 0.859 rs2916076 chr19:19545990 T/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.0 0.3 6.06e-15 Tonsillectomy; BRCA cis rs4930561 0.765 rs4930564 chr11:67983281 C/T cg16338278 chr11:67432957 ALDH3B2 -0.43 -8.94 -0.33 4.08e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs4074536 0.574 rs10801972 chr1:116291575 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.66 -0.32 3.83e-17 QRS duration; BRCA cis rs765787 0.530 rs4238376 chr15:45541887 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.08 0.3 3.2e-15 Uric acid levels; BRCA cis rs17253792 0.822 rs78820104 chr14:56068854 C/T cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA cis rs367943 1.000 rs348955 chr5:112821643 C/T cg12552261 chr5:112820674 MCC -0.55 -12.09 -0.43 1.9e-30 Type 2 diabetes; BRCA cis rs2115536 0.640 rs934134 chr15:80168218 T/C cg02196730 chr15:80188777 MTHFS 0.37 8.5 0.32 1.35e-16 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs9549260 0.753 rs4943794 chr13:41173408 G/C cg21288729 chr13:41239152 FOXO1 0.55 8.8 0.33 1.3e-17 Red blood cell count; BRCA cis rs7589342 0.862 rs10469862 chr2:106509907 C/T cg14210321 chr2:106509881 NCK2 -0.37 -8.0 -0.3 6.02e-15 Addiction; BRCA cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg24324837 chr19:49891574 CCDC155 0.57 10.46 0.38 9.79e-24 Multiple sclerosis; BRCA cis rs16958440 0.867 rs61689863 chr18:44669157 A/T cg17192377 chr18:44677553 HDHD2 0.99 13.87 0.48 1.94e-38 Sitting height ratio; BRCA cis rs1975974 0.935 rs41361749 chr17:21732693 A/G cg18423549 chr17:21743878 NA 0.52 11.29 0.41 4.41e-27 Psoriasis; BRCA cis rs1707322 0.721 rs11211163 chr1:46153548 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8180040 0.871 rs11716661 chr3:47517773 G/T cg16586182 chr3:47516702 SCAP 0.65 15.01 0.51 7.76e-44 Colorectal cancer; BRCA cis rs4653767 1.000 rs4653767 chr1:226916078 T/C cg05049329 chr1:226924846 ITPKB 0.33 9.25 0.34 3.28e-19 Parkinson's disease; BRCA cis rs1707322 1.000 rs1768807 chr1:46510570 A/G cg03146154 chr1:46216737 IPP -0.44 -9.9 -0.36 1.39e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1801251 0.727 rs13029336 chr2:233569935 A/G cg08000102 chr2:233561755 GIGYF2 -0.64 -14.95 -0.51 1.43e-43 Coronary artery disease; BRCA cis rs12760731 0.565 rs12732507 chr1:178098296 A/G cg00404053 chr1:178313656 RASAL2 0.67 8.04 0.3 4.51e-15 Obesity-related traits; BRCA cis rs9420 0.961 rs7117205 chr11:57641883 A/G cg19752551 chr11:57585705 CTNND1 -0.5 -12.33 -0.44 1.82e-31 Schizophrenia; BRCA cis rs8180040 0.966 rs6792461 chr3:47473168 C/T cg16586182 chr3:47516702 SCAP 0.65 15.16 0.51 1.46e-44 Colorectal cancer; BRCA cis rs992157 0.835 rs13031757 chr2:219151926 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.36 -0.41 2.36e-27 Colorectal cancer; BRCA cis rs6594713 0.605 rs11241213 chr5:112851088 T/A cg12552261 chr5:112820674 MCC 0.5 8.01 0.3 5.62e-15 Brain cytoarchitecture; BRCA cis rs6738485 0.763 rs11681976 chr2:106841591 C/A cg16099169 chr2:106886729 NA -0.49 -10.56 -0.39 3.82e-24 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA trans rs12517041 1.000 rs7722738 chr5:23288074 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs2153535 0.580 rs1932282 chr6:8477330 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs826838 0.967 rs1684414 chr12:39129553 A/G cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg18357645 chr12:58087776 OS9 -0.32 -8.02 -0.3 5.21e-15 Multiple sclerosis; BRCA cis rs8180040 0.726 rs34344887 chr3:47042161 A/G cg16586182 chr3:47516702 SCAP -0.53 -12.12 -0.43 1.37e-30 Colorectal cancer; BRCA cis rs10504229 0.683 rs16921814 chr8:58107421 A/T cg20607798 chr8:58055168 NA 0.47 8.02 0.3 4.97e-15 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.601 rs1855765 chr6:8444325 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.79 0.33 1.33e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2180341 0.781 rs7760652 chr6:127572096 A/G cg27446573 chr6:127587934 RNF146 0.7 15.28 0.52 3.52e-45 Breast cancer; BRCA trans rs11098499 0.754 rs12506610 chr4:120241659 T/C cg25214090 chr10:38739885 LOC399744 0.44 10.27 0.38 5.09e-23 Corneal astigmatism; BRCA cis rs72781680 0.799 rs17508218 chr2:23976536 C/T cg08917208 chr2:24149416 ATAD2B 0.87 12.43 0.44 6.24e-32 Lymphocyte counts; BRCA cis rs6951245 0.608 rs10252234 chr7:1114381 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.53 -11.12 -0.4 2.26e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72928364 1.000 rs35517882 chr3:100697174 T/C cg10123952 chr3:100791384 NA 0.53 7.85 0.3 1.71e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs6484504 0.652 rs674035 chr11:31399014 G/A cg14844989 chr11:31128820 NA 0.45 9.61 0.36 1.6e-20 Red blood cell count; BRCA trans rs61931739 0.635 rs4442626 chr12:33912530 C/T cg26384229 chr12:38710491 ALG10B 0.4 8.93 0.33 4.5e-18 Morning vs. evening chronotype; BRCA cis rs2046867 0.862 rs7648954 chr3:72838756 C/A cg25664220 chr3:72788482 NA -0.45 -9.8 -0.36 3.3e-21 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA trans rs35110281 0.667 rs914197 chr21:45117439 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.83 0.33 9.62e-18 Mean corpuscular volume; BRCA cis rs12618769 0.597 rs17505088 chr2:99149473 C/T cg10123293 chr2:99228465 UNC50 0.42 8.15 0.31 1.95e-15 Bipolar disorder; BRCA trans rs11098499 0.954 rs12502423 chr4:120424172 A/C cg25214090 chr10:38739885 LOC399744 0.52 11.67 0.42 1.14e-28 Corneal astigmatism; BRCA cis rs6088580 0.524 rs1321306 chr20:33266379 T/A cg08999081 chr20:33150536 PIGU -0.34 -8.69 -0.33 2.93e-17 Glomerular filtration rate (creatinine); BRCA trans rs7980799 0.682 rs10161491 chr12:33623806 T/C cg26384229 chr12:38710491 ALG10B -0.51 -10.97 -0.4 8.96e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs10504229 1.000 rs72650887 chr8:58177343 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.58 -0.32 7.06e-17 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.49 0.5 2.37e-41 Motion sickness; BRCA cis rs8072100 0.738 rs3736438 chr17:45486651 T/G cg25173405 chr17:45401733 C17orf57 -0.5 -10.58 -0.39 3.31e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9287719 0.649 rs10166765 chr2:10725673 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs9814567 1.000 rs2887797 chr3:134202506 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.78 -0.33 1.46e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2635047 1.000 rs2684818 chr18:44712965 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 8.41 0.32 2.63e-16 Educational attainment; BRCA cis rs10876993 0.890 rs1082502 chr12:58035706 C/T cg18357645 chr12:58087776 OS9 0.43 11.94 0.43 8.5e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs6754311 0.517 rs1865452 chr2:136539330 C/T cg07169764 chr2:136633963 MCM6 1.0 20.32 0.63 3.65e-71 Mosquito bite size; BRCA cis rs55692411 0.517 rs13095697 chr3:50136463 G/A cg24110177 chr3:50126178 RBM5 -0.44 -9.74 -0.36 5.46e-21 Intelligence (multi-trait analysis); BRCA cis rs11030122 0.702 rs10835402 chr11:3990914 T/C cg18678763 chr11:4115507 RRM1 -0.36 -8.15 -0.31 1.97e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs1707322 1.000 rs34444543 chr1:46358862 G/A cg03146154 chr1:46216737 IPP 0.45 9.99 0.37 6.45e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs709400 0.628 rs7155014 chr14:103863970 C/G cg12935359 chr14:103987150 CKB -0.54 -13.2 -0.46 2.42e-35 Body mass index; BRCA cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg06064525 chr11:970664 AP2A2 0.32 9.61 0.36 1.67e-20 Alzheimer's disease (late onset); BRCA cis rs11758351 1.000 rs78012445 chr6:26195080 G/C cg01420254 chr6:26195488 NA 0.58 9.03 0.34 2.08e-18 Gout;Renal underexcretion gout; BRCA cis rs654950 1.000 rs654950 chr1:41987868 G/C cg06885757 chr1:42089581 HIVEP3 -0.29 -9.44 -0.35 6.61e-20 Airway imaging phenotypes; BRCA cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg12311346 chr5:56204834 C5orf35 0.57 11.65 0.42 1.42e-28 Type 2 diabetes; BRCA cis rs2742234 0.541 rs4648313 chr10:43716739 G/A cg02780029 chr10:43622663 RET 0.35 7.86 0.3 1.69e-14 Hirschsprung disease; BRCA cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11644478 chr21:40555479 PSMG1 -0.65 -13.74 -0.48 8.12e-38 Cognitive function; BRCA cis rs9325144 0.600 rs6582634 chr12:38748041 G/A cg26384229 chr12:38710491 ALG10B 0.5 12.27 0.44 3.3e-31 Morning vs. evening chronotype; BRCA cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg08807892 chr2:162101083 NA 0.46 9.11 0.34 1.08e-18 Intelligence (multi-trait analysis); BRCA cis rs13118159 0.550 rs4974611 chr4:1358449 T/C cg16405210 chr4:1374714 KIAA1530 -0.92 -21.01 -0.64 6.92e-75 Longevity; BRCA trans rs61931739 0.500 rs11053235 chr12:34507899 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.58 0.55 1.31e-51 Morning vs. evening chronotype; BRCA cis rs67478160 0.619 rs3742365 chr14:104198251 A/G cg26031613 chr14:104095156 KLC1 -0.47 -9.32 -0.35 1.92e-19 Schizophrenia; BRCA cis rs11955398 0.521 rs6449489 chr5:60026236 A/G cg02684056 chr5:59996105 DEPDC1B -0.4 -9.32 -0.35 1.79e-19 Intelligence (multi-trait analysis); BRCA cis rs3784262 0.565 rs4646605 chr15:58287912 C/A cg12031962 chr15:58353849 ALDH1A2 0.32 8.31 0.31 5.65e-16 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs9649213 0.593 rs1468341 chr7:97987696 G/A cg01877450 chr7:97915802 BRI3 -0.38 -8.45 -0.32 2.01e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs66887589 0.967 rs59516282 chr4:120502016 G/A cg09307838 chr4:120376055 NA -0.43 -8.96 -0.33 3.41e-18 Diastolic blood pressure; BRCA cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg16680214 chr1:154839983 KCNN3 -0.41 -11.24 -0.41 7.02e-27 Prostate cancer; BRCA cis rs8180040 0.966 rs11130128 chr3:47486632 T/C cg16586182 chr3:47516702 SCAP 0.65 15.07 0.51 3.99e-44 Colorectal cancer; BRCA cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 11.53 0.42 4.4e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg20644253 chr19:19431407 KIAA0892;SF4 0.57 11.58 0.42 2.74e-28 Tonsillectomy; BRCA cis rs4713118 0.513 rs149989 chr6:27998184 T/A cg10876282 chr6:28092338 ZSCAN16 0.42 8.15 0.31 1.87e-15 Parkinson's disease; BRCA cis rs61931739 0.500 rs11053197 chr12:34441949 C/T cg06521331 chr12:34319734 NA -0.56 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs2991971 1.000 rs622798 chr1:46015271 T/G cg15605315 chr1:45957053 TESK2 0.45 9.17 0.34 6.53e-19 High light scatter reticulocyte count; BRCA cis rs7917772 0.636 rs2250580 chr10:104505687 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.4 10.06 0.37 3.3e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4237845 0.844 rs4630335 chr12:58302258 A/G cg02175503 chr12:58329896 NA 0.54 11.48 0.41 7.01e-28 Intelligence (multi-trait analysis); BRCA cis rs1163251 0.902 rs514491 chr1:120216743 C/T cg19096424 chr1:120255104 PHGDH 0.44 9.73 0.36 5.98e-21 Blood metabolite levels; BRCA cis rs2455601 0.786 rs3751064 chr11:8958903 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.49 -8.62 -0.32 5.21e-17 Schizophrenia; BRCA cis rs6952808 0.691 rs2398709 chr7:2112548 C/T cg00106254 chr7:1943704 MAD1L1 -0.42 -10.3 -0.38 4.03e-23 Bipolar disorder and schizophrenia; BRCA cis rs2370759 1.000 rs16933243 chr10:32615135 T/C cg01819863 chr10:32635814 EPC1 1.21 21.32 0.64 1.36e-76 Sexual dysfunction (female); BRCA cis rs7582180 0.715 rs920270 chr2:100917961 T/C cg14675211 chr2:100938903 LONRF2 0.46 10.58 0.39 3.16e-24 Intelligence (multi-trait analysis); BRCA cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs7092929 0.941 rs615019 chr10:3563318 T/C cg14308648 chr10:3568949 NA 0.41 7.88 0.3 1.4e-14 Coronary artery calcification; BRCA cis rs7811142 1.000 rs4989959 chr7:100032288 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 21.71 0.65 9.89e-79 Platelet count; BRCA cis rs10129255 0.500 rs34326748 chr14:107190760 G/C cg07958169 chr14:107095056 NA -0.4 -8.6 -0.32 6.3e-17 Kawasaki disease; BRCA trans rs12505749 1.000 rs12505749 chr4:57334112 C/G cg09583921 chr3:87101925 NA 0.8 9.78 0.36 3.79e-21 Airflow obstruction; BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg04267008 chr7:1944627 MAD1L1 -0.57 -11.86 -0.42 1.89e-29 Bipolar disorder and schizophrenia; BRCA trans rs9325144 0.555 rs4882284 chr12:38710459 C/T cg23762105 chr12:34175262 ALG10 0.4 9.73 0.36 5.95e-21 Morning vs. evening chronotype; BRCA cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.42e-31 Bipolar disorder; BRCA cis rs7666738 0.830 rs11940273 chr4:98979965 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.2e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7945718 0.967 rs2241857 chr11:12815831 C/T cg25843174 chr11:12811716 TEAD1 -0.22 -8.26 -0.31 8.49e-16 Educational attainment (years of education); BRCA cis rs7666738 0.830 rs1120708 chr4:98931260 G/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs17685 0.672 rs56343450 chr7:75796235 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11966931 0.948 rs17528484 chr6:108095573 A/G cg10566610 chr6:108093680 SCML4 0.28 8.03 0.3 4.55e-15 Neutrophil percentage of white cells; BRCA cis rs2235642 0.891 rs2281231 chr16:1601879 A/G cg09065629 chr16:1709722 CRAMP1L 0.36 8.6 0.32 6.18e-17 Coronary artery disease; BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg22535103 chr8:58192502 C8orf71 -0.54 -9.19 -0.34 5.5e-19 Developmental language disorder (linguistic errors); BRCA cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg08109568 chr15:31115862 NA 0.45 10.47 0.38 9.04e-24 Huntington's disease progression; BRCA cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg22834771 chr12:69754056 YEATS4 -0.4 -9.99 -0.37 6.34e-22 Cerebrospinal fluid biomarker levels; BRCA cis rs13191362 0.507 rs6936804 chr6:163069424 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.51 -9.38 -0.35 1.14e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs861020 1.000 rs7555285 chr1:209970355 C/G cg05527609 chr1:210001259 C1orf107 -0.59 -12.76 -0.45 2.31e-33 Orofacial clefts; BRCA cis rs17125944 0.686 rs7160582 chr14:53341445 G/T cg00686598 chr14:53173677 PSMC6 0.68 8.07 0.3 3.53e-15 Alzheimer's disease (late onset); BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg04944784 chr2:26401820 FAM59B 1.0 16.79 0.55 1.16e-52 Gut microbiome composition (summer); BRCA cis rs6450176 0.625 rs35027270 chr5:53289068 T/C ch.5.1024479R chr5:53302184 ARL15 -0.68 -15.11 -0.51 2.57e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs3772130 0.923 rs13090798 chr3:121482768 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.75 0.39 7.12e-25 Cognitive performance; BRCA cis rs17095355 1.000 rs12246851 chr10:111726340 C/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.8 -0.36 3.23e-21 Biliary atresia; BRCA trans rs1005277 0.541 rs2472177 chr10:38384015 T/G cg17830980 chr10:43048298 ZNF37B -0.54 -13.04 -0.46 1.2e-34 Extrinsic epigenetic age acceleration; BRCA cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.563 rs2505216 chr10:38482830 T/C cg00409905 chr10:38381863 ZNF37A -0.49 -10.33 -0.38 3.05e-23 Extrinsic epigenetic age acceleration; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg27588902 chr6:42928151 GNMT -0.3 -9.86 -0.36 1.88e-21 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg27170947 chr2:26402098 FAM59B 0.92 16.52 0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs12367572 0.540 rs7954773 chr12:45455769 C/T cg04608330 chr12:45269318 NELL2 0.38 7.9 0.3 1.24e-14 Gut microbiome composition (summer); BRCA cis rs12711979 0.740 rs6711963 chr2:3820915 A/T cg17052675 chr2:3827356 NA -0.48 -14.31 -0.49 1.8e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg26314531 chr2:26401878 FAM59B -0.93 -16.24 -0.54 6.53e-50 Gut microbiome composition (summer); BRCA cis rs1506636 0.886 rs6945841 chr7:123266094 G/A cg03229431 chr7:123269106 ASB15 -0.68 -15.75 -0.53 1.75e-47 Plateletcrit;Platelet count; BRCA cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.45 10.05 0.37 3.66e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.13e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72792276 1.000 rs72794370 chr5:127444907 T/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.63 10.71 0.39 9.84e-25 Red cell distribution width; BRCA cis rs36051895 0.664 rs10116560 chr9:5096433 A/G cg02405213 chr9:5042618 JAK2 -0.51 -9.2 -0.34 5.1e-19 Pediatric autoimmune diseases; BRCA cis rs11105298 0.891 rs4842661 chr12:89930399 A/G cg00757033 chr12:89920650 WDR51B 0.5 9.63 0.36 1.37e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7851660 0.967 rs907577 chr9:100615117 C/T cg13688889 chr9:100608707 NA -0.36 -8.72 -0.33 2.42e-17 Strep throat; BRCA trans rs60843830 1.000 rs79716074 chr2:277003 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 14.39 0.49 6.92e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2576037 0.526 rs4890699 chr18:44541029 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.99 0.43 5.35e-30 Personality dimensions; BRCA cis rs10465746 0.725 rs6694752 chr1:84389960 C/T cg10977910 chr1:84465055 TTLL7 0.62 13.0 0.46 1.92e-34 Obesity-related traits; BRCA cis rs17270561 0.723 rs12192635 chr6:25880907 A/T cg16482183 chr6:26056742 HIST1H1C 0.71 14.49 0.5 2.4e-41 Iron status biomarkers; BRCA cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg08704250 chr15:31115839 NA 0.45 12.43 0.44 6.15e-32 Huntington's disease progression; BRCA cis rs870825 0.616 rs6844146 chr4:185636396 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs826838 0.904 rs10876086 chr12:39188208 C/A cg26384229 chr12:38710491 ALG10B 0.8 19.69 0.61 7.86e-68 Heart rate; BRCA trans rs60843830 1.000 rs17713729 chr2:249092 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.65 14.36 0.49 9.95e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg21280719 chr6:42927975 GNMT -0.32 -13.22 -0.46 2e-35 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs847577 0.722 rs1013886 chr7:97709861 A/G cg21770322 chr7:97807741 LMTK2 -0.56 -16.08 -0.54 4.26e-49 Breast cancer; BRCA trans rs1997103 1.000 rs2177805 chr7:55404381 T/A cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9649213 0.614 rs9640655 chr7:98017099 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.87 -0.53 4.83e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.07 16.15 0.54 1.85e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11585357 0.689 rs2977293 chr1:17599444 C/T cg08277548 chr1:17600880 PADI3 -0.52 -9.53 -0.35 3.11e-20 Hair shape; BRCA cis rs10782582 0.609 rs5745430 chr1:76332994 C/T cg03433033 chr1:76189801 ACADM -0.41 -8.36 -0.31 3.8e-16 Daytime sleep phenotypes; BRCA cis rs35306767 0.903 rs17159970 chr10:935601 T/C cg26597838 chr10:835615 NA 1.02 17.92 0.58 1.75e-58 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.580 rs9392223 chr6:8468650 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.08 0.49 1.97e-39 Motion sickness; BRCA cis rs921968 0.541 rs933994 chr2:219650616 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.58 -0.39 3.17e-24 Mean corpuscular hemoglobin concentration; BRCA trans rs3780486 0.505 rs10758188 chr9:33123386 C/T cg20290983 chr6:43655470 MRPS18A -0.83 -22.55 -0.67 2.73e-83 IgG glycosylation; BRCA cis rs12579753 0.869 rs12366920 chr12:82223015 G/A cg07988820 chr12:82153109 PPFIA2 -0.62 -10.1 -0.37 2.44e-22 Resting heart rate; BRCA cis rs9503598 0.714 rs7758776 chr6:3452245 C/T cg00476032 chr6:3446245 SLC22A23 0.44 11.14 0.4 1.83e-26 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs12477438 1.000 rs995617 chr2:99857904 G/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.77 15.35 0.52 1.63e-45 Chronic sinus infection; BRCA cis rs4713118 0.826 rs2893929 chr6:27738732 A/T cg20933634 chr6:27740509 NA 0.47 8.87 0.33 7.41e-18 Parkinson's disease; BRCA cis rs6912958 0.559 rs173333 chr6:88047754 T/G cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.3 0.41 4e-27 Monocyte percentage of white cells; BRCA cis rs13315871 0.929 rs7635697 chr3:58313706 G/A cg20936604 chr3:58311152 NA -0.64 -8.2 -0.31 1.36e-15 Cholesterol, total; BRCA cis rs3820928 0.605 rs10186145 chr2:227781150 A/G cg05526886 chr2:227700861 RHBDD1 -0.43 -8.96 -0.33 3.55e-18 Pulmonary function; BRCA cis rs2832191 0.716 rs1888439 chr21:30454457 A/G cg08807101 chr21:30365312 RNF160 0.74 19.34 0.61 5.64e-66 Dental caries; BRCA trans rs7647973 0.626 rs62260720 chr3:49853796 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.38 7.96 0.3 7.64e-15 Menarche (age at onset); BRCA cis rs13053817 1.000 rs13057815 chr22:29853526 T/C cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.47 -8.95 -0.33 3.83e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs2191566 0.576 rs396148 chr19:44494548 A/T cg20607764 chr19:44506953 ZNF230 0.37 7.99 0.3 6.17e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs2836974 0.966 rs7283516 chr21:40690537 A/G cg11890956 chr21:40555474 PSMG1 1.04 28.18 0.74 3.6e-114 Cognitive function; BRCA cis rs2842992 0.872 rs2758315 chr6:160158640 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.68 17.54 0.57 1.57e-56 Age-related macular degeneration (geographic atrophy); BRCA trans rs7939886 0.920 rs12223067 chr11:55915420 C/A cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs6582630 0.502 rs11520279 chr12:38360871 A/G cg26384229 chr12:38710491 ALG10B 0.69 16.21 0.54 9.67e-50 Drug-induced liver injury (flucloxacillin); BRCA cis rs4363385 0.747 rs4845504 chr1:152960043 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.39 -0.35 1.06e-19 Inflammatory skin disease; BRCA cis rs7582180 0.739 rs11123822 chr2:100911582 G/T cg14675211 chr2:100938903 LONRF2 0.42 9.34 0.35 1.63e-19 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs7592691 chr2:10737426 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs495337 0.760 rs492702 chr20:48522585 G/A cg17835207 chr20:48524531 SPATA2 -0.67 -15.97 -0.53 1.4e-48 Psoriasis; BRCA cis rs7737355 1.000 rs2549018 chr5:130698949 C/T cg06307176 chr5:131281290 NA -0.44 -8.64 -0.32 4.51e-17 Life satisfaction; BRCA trans rs6582630 0.555 rs7301250 chr12:38596244 G/T cg06521331 chr12:34319734 NA -0.43 -8.1 -0.31 2.79e-15 Drug-induced liver injury (flucloxacillin); BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg20007245 chr22:24372913 LOC391322 0.8 19.87 0.62 8.56e-69 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2836974 0.899 rs2836938 chr21:40574191 C/T cg17971929 chr21:40555470 PSMG1 0.8 18.64 0.59 2.88e-62 Cognitive function; BRCA cis rs10754283 0.967 rs1934045 chr1:90107799 A/C cg21401794 chr1:90099060 LRRC8C -0.45 -10.82 -0.39 3.66e-25 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs10197940 0.662 rs10173699 chr2:152281561 C/G cg19508488 chr2:152266495 RIF1 -0.49 -9.73 -0.36 5.98e-21 Lung cancer; BRCA cis rs736408 0.660 rs2019065 chr3:52809525 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.35 -12.14 -0.43 1.2e-30 Bipolar disorder; BRCA cis rs2404602 0.716 rs4079681 chr15:76695230 G/A cg22467129 chr15:76604101 ETFA -0.49 -10.79 -0.39 4.79e-25 Blood metabolite levels; BRCA cis rs1057239 0.510 rs3766694 chr1:175143207 T/C cg17845761 chr1:175162550 KIAA0040 -0.25 -9.33 -0.35 1.74e-19 Diastolic blood pressure; BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg00106254 chr7:1943704 MAD1L1 -0.39 -9.62 -0.36 1.44e-20 Bipolar disorder and schizophrenia; BRCA cis rs2404602 0.716 rs12592171 chr15:76755133 G/C cg22467129 chr15:76604101 ETFA -0.49 -10.82 -0.39 3.71e-25 Blood metabolite levels; BRCA cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg03351412 chr1:154909251 PMVK -0.57 -12.64 -0.45 7.3e-33 Prostate cancer; BRCA cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg15112475 chr7:1198522 ZFAND2A -0.61 -15.79 -0.53 1.14e-47 Longevity;Endometriosis; BRCA cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg22875332 chr1:76189707 ACADM -0.51 -9.8 -0.36 3.14e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs651907 0.535 rs36060163 chr3:101360963 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.96 0.51 1.35e-43 Colorectal cancer; BRCA cis rs1568889 0.838 rs10767708 chr11:28294847 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 19.53 0.61 5.57e-67 Bipolar disorder; BRCA cis rs12971120 0.891 rs4891558 chr18:72170359 A/G cg25817165 chr18:72167213 CNDP2 -0.78 -14.18 -0.49 7.13e-40 Refractive error; BRCA cis rs7267979 1.000 rs2482940 chr20:25349830 C/T cg08601574 chr20:25228251 PYGB -0.39 -9.05 -0.34 1.77e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9311474 0.632 rs6445528 chr3:52572447 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.34 -11.73 -0.42 6.71e-29 Electroencephalogram traits; BRCA cis rs2404602 0.647 rs12440511 chr15:76993135 A/G cg23625390 chr15:77176239 SCAPER -0.56 -13.28 -0.47 9.99e-36 Blood metabolite levels; BRCA cis rs3818285 0.959 rs3740137 chr10:111630917 G/A cg00817464 chr10:111662876 XPNPEP1 -0.35 -8.75 -0.33 1.94e-17 Superior crus of antihelix expression; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg18402987 chr7:1209562 NA 0.62 13.12 0.46 5.3e-35 Longevity;Endometriosis; BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.29 -0.44 2.57e-31 Alzheimer's disease; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.71 -0.53 2.9e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1843834 0.539 rs6713629 chr2:225410973 A/T cg12698349 chr2:225449008 CUL3 0.6 13.17 0.46 3.24e-35 IgE levels in asthmatics (D.p. specific); BRCA cis rs9443645 0.901 rs9352675 chr6:79612800 G/A cg05283184 chr6:79620031 NA -0.43 -11.03 -0.4 4.97e-26 Intelligence (multi-trait analysis); BRCA cis rs853679 0.607 rs200489 chr6:27798257 T/C cg26587870 chr6:27730563 NA -0.57 -8.6 -0.32 6.17e-17 Depression; BRCA trans rs66887589 0.807 rs13134517 chr4:120405262 G/A cg25214090 chr10:38739885 LOC399744 0.35 7.92 0.3 1.04e-14 Diastolic blood pressure; BRCA cis rs12824058 0.831 rs55726136 chr12:130810312 G/A cg26677194 chr12:130822605 PIWIL1 0.6 14.33 0.49 1.31e-40 Menopause (age at onset); BRCA cis rs1577917 0.739 rs9450318 chr6:86427177 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.47 13.57 0.47 4.68e-37 Response to antipsychotic treatment; BRCA cis rs6724607 0.905 rs7603849 chr2:191438741 A/C cg10560079 chr2:191398806 TMEM194B 0.4 8.85 0.33 8.67e-18 Pulse pressure; BRCA cis rs7666738 0.830 rs60994860 chr4:99046753 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.962 rs6089826 chr20:61668595 G/A cg03213289 chr20:61660250 NA 0.62 16.24 0.54 6.75e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg19678392 chr7:94953810 PON1 -0.43 -9.14 -0.34 8e-19 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4713118 0.515 rs9368549 chr6:28050047 T/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.94 0.3 8.88e-15 Parkinson's disease; BRCA cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg14926445 chr8:58193284 C8orf71 -0.47 -8.93 -0.33 4.61e-18 Developmental language disorder (linguistic errors); BRCA cis rs11608355 0.545 rs6606724 chr12:109905179 T/C cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA trans rs17685 0.753 rs10952840 chr7:75772878 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 27.27 0.73 3.26e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11098499 0.820 rs6534140 chr4:120455311 C/T cg09307838 chr4:120376055 NA 0.69 14.02 0.49 3.82e-39 Corneal astigmatism; BRCA cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg18876405 chr7:65276391 NA 0.7 18.57 0.59 6.72e-62 Aortic root size; BRCA trans rs3780486 0.846 rs7865745 chr9:33140976 A/G cg04842962 chr6:43655489 MRPS18A -1.11 -39.21 -0.84 3.28e-172 IgG glycosylation; BRCA trans rs8062405 0.754 rs151179 chr16:28487056 A/G cg09719594 chr16:21412588 NA -0.36 -8.25 -0.31 9.28e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.943 rs10420754 chr19:37959372 C/G cg18154014 chr19:37997991 ZNF793 0.48 9.45 0.35 6.08e-20 Coronary artery calcification; BRCA cis rs6433895 0.736 rs13011751 chr2:181985765 A/T cg00481216 chr2:181971175 NA 0.41 8.74 0.33 2.02e-17 Lymphocyte counts; BRCA cis rs17401966 0.894 rs12141201 chr1:10454714 G/A cg03954927 chr1:10346856 KIF1B 0.48 14.58 0.5 9.03e-42 Hepatocellular carcinoma; BRCA cis rs2276314 0.857 rs28530656 chr18:33588700 C/T cg19628046 chr18:33552617 C18orf21 -0.56 -11.59 -0.42 2.47e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg08470875 chr2:26401718 FAM59B 0.51 8.24 0.31 9.42e-16 Gut microbiome composition (summer); BRCA cis rs1784581 1.000 rs1784582 chr6:162400712 A/G cg17173639 chr6:162384350 PARK2 -0.43 -10.1 -0.37 2.33e-22 Itch intensity from mosquito bite; BRCA cis rs3008870 1.000 rs2755256 chr1:67471692 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.83 0.65 2.21e-79 Lymphocyte percentage of white cells; BRCA cis rs365132 0.870 rs2454949 chr5:176466011 G/A cg16309518 chr5:176445507 NA -0.51 -12.95 -0.46 3.29e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA trans rs11098499 0.909 rs28632018 chr4:120386730 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 8.92e-15 Corneal astigmatism; BRCA cis rs16958440 1.000 rs62096463 chr18:44628928 A/G cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg11168104 chr5:1857477 NA -0.34 -8.98 -0.33 3.12e-18 Cardiovascular disease risk factors; BRCA cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg06636001 chr8:8085503 FLJ10661 -0.68 -15.46 -0.52 4.8e-46 Mood instability; BRCA cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg08280861 chr8:58055591 NA 0.54 8.68 0.32 3.35e-17 Developmental language disorder (linguistic errors); BRCA cis rs66887589 0.774 rs9307477 chr4:120421809 G/A cg09307838 chr4:120376055 NA 0.47 9.75 0.36 4.82e-21 Diastolic blood pressure; BRCA cis rs1003719 0.762 rs3787786 chr21:38463436 T/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs4074536 0.574 rs10801973 chr1:116291664 A/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.66 -0.32 3.83e-17 QRS duration; BRCA trans rs11098499 0.739 rs2203039 chr4:120132347 T/C cg25214090 chr10:38739885 LOC399744 -0.46 -9.72 -0.36 6.52e-21 Corneal astigmatism; BRCA trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg03929089 chr4:120376271 NA 0.78 18.1 0.58 2.1e-59 Coronary artery disease; BRCA cis rs4595586 0.545 rs12812762 chr12:39371141 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.35 0.35 1.47e-19 Morning vs. evening chronotype; BRCA cis rs7809950 0.953 rs1468336 chr7:107208250 T/C cg23024343 chr7:107201750 COG5 0.39 8.59 0.32 6.81e-17 Coronary artery disease; BRCA cis rs6878727 0.850 rs2408163 chr5:123707016 C/T cg01806427 chr5:123737813 NA 0.41 9.46 0.35 5.6e-20 Breast cancer; BRCA trans rs561341 1.000 rs72825740 chr17:30338356 A/G cg27661571 chr11:113659931 NA -0.83 -12.14 -0.43 1.15e-30 Hip circumference adjusted for BMI; BRCA cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg26384229 chr12:38710491 ALG10B 0.73 17.15 0.56 1.68e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs694739 0.595 rs11606015 chr11:64136877 C/G cg02228329 chr11:64053129 BAD;GPR137 0.53 11.76 0.42 4.62e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs3093024 0.595 rs4458654 chr6:167476068 A/C cg07741184 chr6:167504864 NA 0.36 10.48 0.38 7.88e-24 Rheumatoid arthritis; BRCA cis rs2115536 0.692 rs6495450 chr15:80162499 C/A cg02196730 chr15:80188777 MTHFS 0.35 8.0 0.3 5.75e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs7772486 0.875 rs1331644 chr6:146398660 T/C cg23711669 chr6:146136114 FBXO30 0.71 16.31 0.54 3.01e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 1.000 rs2268758 chr3:38514049 C/T cg24069376 chr3:38537580 EXOG 0.42 11.92 0.43 9.72e-30 Electrocardiographic conduction measures; BRCA cis rs61931739 0.534 rs7133262 chr12:34279444 G/A cg06521331 chr12:34319734 NA -0.65 -11.98 -0.43 5.75e-30 Morning vs. evening chronotype; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg22920501 chr2:26401640 FAM59B 0.92 16.83 0.55 6.68e-53 Gut microbiome composition (summer); BRCA cis rs2015599 0.549 rs6487799 chr12:29444020 A/G cg09582351 chr12:29534625 ERGIC2 -0.35 -8.23 -0.31 1.05e-15 Mean platelet volume;Platelet count; BRCA cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg18357526 chr6:26021779 HIST1H4A 0.47 8.72 0.33 2.37e-17 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs6050561 chr20:25334855 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.28 -0.34 2.6e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4631830 0.720 rs898343 chr10:51505403 A/G cg20129853 chr10:51489980 NA 0.31 8.36 0.31 3.84e-16 Prostate-specific antigen levels; BRCA cis rs9311474 0.607 rs28661185 chr3:52567188 G/T cg18404041 chr3:52824283 ITIH1 -0.4 -12.18 -0.43 7.56e-31 Electroencephalogram traits; BRCA cis rs7715806 0.500 rs72633984 chr5:75005899 A/G cg19683494 chr5:74908142 NA 0.5 8.1 0.31 2.81e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg21518248 chr2:162101506 NA 0.51 10.92 0.4 1.48e-25 Intelligence (multi-trait analysis); BRCA cis rs701145 0.762 rs896014 chr3:153842691 A/G cg12800244 chr3:153838788 SGEF 0.63 7.87 0.3 1.53e-14 Coronary artery disease; BRCA cis rs11711311 0.747 rs2895415 chr3:113345565 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -9.13 -0.34 8.66e-19 IgG glycosylation; BRCA cis rs10791323 0.604 rs2250025 chr11:133710914 G/A cg15485101 chr11:133734466 NA 0.4 9.46 0.35 5.7e-20 Childhood ear infection; BRCA cis rs6952808 0.543 rs4719436 chr7:2141239 G/A cg02951883 chr7:2050386 MAD1L1 -0.54 -12.3 -0.44 2.23e-31 Bipolar disorder and schizophrenia; BRCA cis rs9837602 1.000 rs9873878 chr3:99711816 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.28 0.41 4.85e-27 Breast cancer; BRCA cis rs4819052 0.851 rs2838850 chr21:46671445 G/C cg06618935 chr21:46677482 NA -0.39 -8.63 -0.32 4.85e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg12311346 chr5:56204834 C5orf35 -0.63 -13.29 -0.47 9.39e-36 Initial pursuit acceleration; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19346786 chr7:2764209 NA -0.32 -9.4 -0.35 9.36e-20 Height; BRCA cis rs7666738 0.791 rs6833691 chr4:98951508 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs11165623 0.792 rs9437607 chr1:96977788 G/A cg10631902 chr5:14652156 NA -0.49 -15.39 -0.52 1.06e-45 Hip circumference;Waist circumference; BRCA cis rs1552244 0.572 rs3894322 chr3:10168965 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 14.28 0.49 2.44e-40 Alzheimer's disease; BRCA cis rs428668 0.523 rs3926389 chr5:150677806 C/T cg14086364 chr5:150678334 SLC36A3 0.53 14.7 0.5 2.44e-42 Skin aging (microtopography measurement); BRCA cis rs9287719 0.649 rs12621977 chr2:10721931 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs7301016 0.802 rs11613011 chr12:63023078 T/C cg11441379 chr12:63026424 NA 0.49 8.94 0.33 4.06e-18 IgG glycosylation; BRCA cis rs2839186 0.872 rs13046834 chr21:47701485 T/C cg12379764 chr21:47803548 PCNT -0.37 -8.05 -0.3 4.13e-15 Testicular germ cell tumor; BRCA cis rs7927771 0.524 rs12286721 chr11:47701528 G/T cg20307385 chr11:47447363 PSMC3 -0.39 -9.16 -0.34 7.09e-19 Subjective well-being; BRCA cis rs758324 0.947 rs4705903 chr5:131206594 A/C cg06307176 chr5:131281290 NA 0.57 12.0 0.43 4.56e-30 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1499614 1.000 rs2659913 chr7:66157336 T/A cg18252515 chr7:66147081 NA -1.06 -15.7 -0.53 3.07e-47 Gout; BRCA cis rs7095944 0.614 rs1055256 chr10:126446592 A/G cg08799069 chr10:126477246 METTL10 -0.4 -10.05 -0.37 3.72e-22 Asthma; BRCA cis rs6964587 0.692 rs7807490 chr7:91773359 A/G cg17063962 chr7:91808500 NA 0.57 13.29 0.47 9.33e-36 Breast cancer; BRCA cis rs2304069 0.954 rs10068537 chr5:149403193 G/A cg22760475 chr5:149380129 HMGXB3;TIGD6 0.83 16.51 0.55 3.07e-51 HIV-1 control; BRCA cis rs2842992 0.789 rs9355748 chr6:160194882 G/A cg11366901 chr6:160182831 ACAT2 0.83 16.16 0.54 1.67e-49 Age-related macular degeneration (geographic atrophy); BRCA cis rs12701220 0.655 rs6955290 chr7:1151066 A/G cg04025307 chr7:1156635 C7orf50 -0.49 -9.85 -0.36 2.11e-21 Bronchopulmonary dysplasia; BRCA cis rs826838 1.000 rs11183941 chr12:38851692 G/C cg26384229 chr12:38710491 ALG10B 0.85 22.52 0.67 3.94e-83 Heart rate; BRCA cis rs3772130 0.962 rs6791046 chr3:121394707 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.28 0.34 2.58e-19 Cognitive performance; BRCA cis rs752010 0.714 rs7513753 chr1:42079232 A/G cg06885757 chr1:42089581 HIVEP3 0.27 10.14 0.37 1.69e-22 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs897984 0.568 rs4889651 chr16:30895545 C/T cg02466173 chr16:30829666 NA -0.4 -8.2 -0.31 1.28e-15 Dementia with Lewy bodies; BRCA cis rs67366981 1.000 rs56357623 chr14:77697393 C/A cg22824376 chr14:77648248 TMEM63C 0.62 9.17 0.34 6.45e-19 Obsessive-compulsive symptoms; BRCA cis rs7267979 1.000 rs6083805 chr20:25317356 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.37 -0.31 3.55e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs8031584 0.541 rs2955797 chr15:31210981 A/G cg08704250 chr15:31115839 NA 0.34 8.72 0.33 2.49e-17 Huntington's disease progression; BRCA cis rs1552244 1.000 rs13319597 chr3:10126312 A/C cg00149659 chr3:10157352 C3orf10 -0.68 -11.89 -0.43 1.34e-29 Alzheimer's disease; BRCA cis rs2549003 0.811 rs10035166 chr5:131823927 C/T cg02551604 chr5:131831745 NA 0.35 9.97 0.37 7.43e-22 Asthma (sex interaction); BRCA cis rs10911232 0.507 rs4129857 chr1:183004547 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.7 0.55 3.14e-52 Hypertriglyceridemia; BRCA cis rs6728642 1.000 rs75297860 chr2:97600078 G/A cg26665480 chr2:98280029 ACTR1B -0.68 -7.81 -0.3 2.3e-14 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs9291683 0.507 rs3796837 chr4:10011321 C/G cg11266682 chr4:10021025 SLC2A9 0.47 12.59 0.45 1.2e-32 Bone mineral density; BRCA cis rs11098499 0.604 rs34278750 chr4:120571136 G/A cg09307838 chr4:120376055 NA 0.58 10.92 0.4 1.48e-25 Corneal astigmatism; BRCA cis rs4727027 0.866 rs10435245 chr7:148816081 C/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.82 0.33 1.06e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs34779708 0.931 rs12776390 chr10:35391535 T/G cg03585969 chr10:35415529 CREM 0.5 10.42 0.38 1.36e-23 Inflammatory bowel disease;Crohn's disease; BRCA trans rs783540 0.967 rs1145172 chr15:83223616 T/C cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.13 -0.31 2.27e-15 Schizophrenia; BRCA cis rs9341808 0.739 rs4706831 chr6:81007699 T/C cg08355045 chr6:80787529 NA 0.36 9.32 0.35 1.88e-19 Sitting height ratio; BRCA cis rs6700896 0.866 rs6588158 chr1:66160621 T/C cg04111102 chr1:66153794 NA -0.34 -8.5 -0.32 1.3e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs28374715 0.528 rs28492932 chr15:41624397 G/C cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.8 -0.71 4.21e-101 Ulcerative colitis; BRCA cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg11266682 chr4:10021025 SLC2A9 -0.41 -11.1 -0.4 2.55e-26 Bone mineral density; BRCA cis rs652260 0.646 rs693941 chr19:7903851 C/T cg26014689 chr19:7917955 EVI5L -0.62 -14.79 -0.5 9.27e-43 Menarche (age at onset); BRCA cis rs1862618 0.802 rs42769 chr5:56144152 G/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.39 -0.38 1.72e-23 Initial pursuit acceleration; BRCA cis rs7647973 0.731 rs13084037 chr3:49214066 G/A cg07636037 chr3:49044803 WDR6 0.68 12.26 0.44 3.36e-31 Menarche (age at onset); BRCA cis rs6541297 1.000 rs1998065 chr1:230286647 T/G cg20703242 chr1:230279135 GALNT2 0.48 10.32 0.38 3.32e-23 Coronary artery disease; BRCA cis rs35306767 0.903 rs11253467 chr10:901244 A/G cg25019033 chr10:957182 NA -0.41 -7.9 -0.3 1.25e-14 Eosinophil percentage of granulocytes; BRCA cis rs17376456 0.877 rs10061080 chr5:93420559 A/G cg25358565 chr5:93447407 FAM172A 1.18 19.74 0.62 4.16e-68 Diabetic retinopathy; BRCA cis rs9649213 0.555 rs34695842 chr7:97931062 G/T cg21770322 chr7:97807741 LMTK2 0.44 11.86 0.42 1.77e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs11098499 0.955 rs35434465 chr4:120169378 C/G cg09307838 chr4:120376055 NA 0.63 12.63 0.45 8.32e-33 Corneal astigmatism; BRCA cis rs79839061 0.610 rs3775122 chr4:893287 A/G cg14530993 chr4:882597 GAK -0.56 -9.84 -0.36 2.28e-21 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.744 rs162373 chr21:44927107 C/A cg21573476 chr21:45109991 RRP1B 0.37 9.71 0.36 7.19e-21 Mean corpuscular volume; BRCA trans rs6952808 0.500 rs3778996 chr7:2177190 G/A cg04565464 chr8:145669602 NFKBIL2 0.41 8.76 0.33 1.74e-17 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.78 0.33 1.48e-17 Motion sickness; BRCA cis rs870825 0.549 rs10015956 chr4:185614705 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.1 0.56 2.98e-54 Blood protein levels; BRCA trans rs11098499 0.863 rs9884402 chr4:120489982 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.16 0.31 1.73e-15 Corneal astigmatism; BRCA cis rs11577318 0.796 rs4625269 chr1:26626967 C/A cg00852783 chr1:26633632 UBXN11 0.51 10.97 0.4 9.2e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 16.41 0.54 9.04e-51 Platelet count; BRCA cis rs9420 0.961 rs77993055 chr11:57522840 C/T cg19752551 chr11:57585705 CTNND1 -0.51 -12.56 -0.45 1.68e-32 Schizophrenia; BRCA cis rs644148 0.967 rs613876 chr19:44968788 T/C cg15540054 chr19:45004280 ZNF180 -0.57 -12.07 -0.43 2.42e-30 Personality dimensions; BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg11062466 chr8:58055876 NA 0.55 9.28 0.34 2.6e-19 Developmental language disorder (linguistic errors); BRCA cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg02012338 chr4:187126139 CYP4V2 0.88 10.36 0.38 2.38e-23 Blood protein levels; BRCA cis rs4690686 0.538 rs4690428 chr4:177263665 C/T cg17059388 chr4:177262070 NA 0.51 10.68 0.39 1.34e-24 Essential tremor; BRCA cis rs17095355 0.642 rs57822924 chr10:111702078 G/A cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.56 -0.35 2.58e-20 Biliary atresia; BRCA cis rs6901250 0.851 rs2175622 chr6:117149667 T/A cg12892004 chr6:117198278 RFX6 0.49 11.34 0.41 2.67e-27 C-reactive protein levels; BRCA cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg06238570 chr21:40685208 BRWD1 -0.42 -8.65 -0.32 4.03e-17 Cognitive function; BRCA cis rs2836974 0.897 rs8132295 chr21:40527774 A/G cg17971929 chr21:40555470 PSMG1 -0.78 -18.82 -0.6 3.35e-63 Cognitive function; BRCA cis rs2404602 1.000 rs12898430 chr15:76874923 G/A cg23625390 chr15:77176239 SCAPER 0.39 9.65 0.36 1.18e-20 Blood metabolite levels; BRCA cis rs61931739 0.517 rs12367881 chr12:34175508 T/C cg06521331 chr12:34319734 NA -0.62 -11.38 -0.41 1.83e-27 Morning vs. evening chronotype; BRCA trans rs7824557 0.806 rs7007394 chr8:11094566 G/A cg15556689 chr8:8085844 FLJ10661 -0.34 -8.45 -0.32 1.91e-16 Retinal vascular caliber; BRCA trans rs6089829 0.962 rs4997812 chr20:61663153 T/G cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7833986 0.501 rs2953922 chr8:56977485 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.36 0.47 4.56e-36 Height; BRCA cis rs61008539 0.853 rs10950611 chr7:861094 G/T cg15782153 chr7:917662 C7orf20 0.39 9.36 0.35 1.3e-19 Perceived unattractiveness to mosquitoes; BRCA cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg01877450 chr7:97915802 BRI3 -0.37 -8.42 -0.32 2.41e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs9487051 0.698 rs4301336 chr6:109650140 A/T cg21918786 chr6:109611834 NA 0.37 8.57 0.32 8.05e-17 Reticulocyte fraction of red cells; BRCA cis rs780096 0.565 rs13022659 chr2:27743630 C/T cg17158414 chr2:27665306 KRTCAP3 -0.31 -7.84 -0.3 1.84e-14 Total body bone mineral density; BRCA cis rs9807989 0.507 rs4851579 chr2:103028984 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma; BRCA cis rs7394190 0.748 rs11541237 chr10:75530962 C/T cg07699608 chr10:75541558 CHCHD1 0.65 9.64 0.36 1.26e-20 Incident atrial fibrillation; BRCA cis rs9814567 1.000 rs6793487 chr3:134299426 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.58 18.99 0.6 4.37e-64 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2303759 0.670 rs45549132 chr19:49794028 G/T cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.22 0.31 1.14e-15 Multiple sclerosis; BRCA trans rs10506458 0.915 rs1463821 chr12:63402875 C/G cg22491629 chr6:157744540 C6orf35 0.62 11.18 0.4 1.26e-26 Hemostatic factors and hematological phenotypes; BRCA cis rs67460515 0.506 rs935497 chr3:160600563 A/G cg03342759 chr3:160939853 NMD3 -0.64 -13.13 -0.46 4.98e-35 Parkinson's disease; BRCA cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg15485101 chr11:133734466 NA 0.41 9.71 0.36 6.75e-21 Childhood ear infection; BRCA cis rs17270561 0.609 rs1892255 chr6:25750354 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.74 0.33 2.11e-17 Iron status biomarkers; BRCA cis rs9325144 0.541 rs7303395 chr12:38664124 C/T cg26384229 chr12:38710491 ALG10B -0.54 -13.47 -0.47 1.4e-36 Morning vs. evening chronotype; BRCA cis rs11098499 0.644 rs2389880 chr4:120559870 T/A cg09307838 chr4:120376055 NA 0.59 12.25 0.44 4.04e-31 Corneal astigmatism; BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.52 -0.32 1.13e-16 Menopause (age at onset); BRCA cis rs936229 0.798 rs1869959 chr15:75147332 A/C cg10253484 chr15:75165896 SCAMP2 -0.53 -10.09 -0.37 2.7e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6901250 0.587 rs339357 chr6:117198291 G/C cg12892004 chr6:117198278 RFX6 -0.5 -11.51 -0.41 5.51e-28 C-reactive protein levels; BRCA cis rs13256369 0.951 rs10503394 chr8:8565775 A/G cg17143192 chr8:8559678 CLDN23 0.56 11.03 0.4 5.36e-26 Obesity-related traits; BRCA cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg19748678 chr4:122722346 EXOSC9 0.71 15.24 0.52 5.59e-45 Type 2 diabetes; BRCA cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg02503808 chr4:7069936 GRPEL1 0.72 14.0 0.48 4.85e-39 Monocyte percentage of white cells; BRCA cis rs6484504 0.600 rs10835763 chr11:31345574 G/A cg06552810 chr11:31128660 NA 0.4 8.66 0.32 3.75e-17 Red blood cell count; BRCA cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg03644281 chr6:41068752 NFYA;LOC221442 -0.44 -8.15 -0.31 1.9e-15 Alzheimer's disease (late onset); BRCA trans rs11098499 0.954 rs12499324 chr4:120393786 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.1 0.31 2.88e-15 Corneal astigmatism; BRCA cis rs6435161 1.000 rs72926990 chr2:203520420 G/A cg18429434 chr2:203499731 FAM117B -0.44 -8.76 -0.33 1.78e-17 Total cholesterol levels; BRCA cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.55 -0.32 9.19e-17 Monocyte percentage of white cells; BRCA trans rs7200543 0.961 rs1741 chr16:15130351 G/C cg24683922 chr1:11983373 KIAA2013 -0.39 -8.73 -0.33 2.23e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA trans rs6598955 0.671 rs11247904 chr1:26621804 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.64 -14.47 -0.5 3.14e-41 Obesity-related traits; BRCA cis rs7646881 1.000 rs73015655 chr3:158451882 A/C cg19483011 chr3:158453295 NA -0.41 -8.05 -0.3 3.97e-15 Tetralogy of Fallot; BRCA cis rs6901250 0.851 rs7740481 chr6:117149307 G/C cg12892004 chr6:117198278 RFX6 0.48 11.29 0.41 4.59e-27 C-reactive protein levels; BRCA trans rs6952808 0.691 rs2398709 chr7:2112548 C/T cg04565464 chr8:145669602 NFKBIL2 0.41 9.22 0.34 4.42e-19 Bipolar disorder and schizophrenia; BRCA cis rs490234 0.841 rs7044663 chr9:128268263 C/T cg14078157 chr9:128172775 NA -0.35 -8.11 -0.31 2.6e-15 Mean arterial pressure; BRCA cis rs763014 1.000 rs7205409 chr16:642610 A/G cg09263875 chr16:632152 PIGQ 0.66 18.53 0.59 1.17e-61 Height; BRCA cis rs4563143 0.647 rs73029014 chr19:29257655 G/C cg12667521 chr19:29218732 NA 0.47 8.77 0.33 1.63e-17 Methadone dose in opioid dependence; BRCA cis rs16867321 0.614 rs12693245 chr2:181445110 T/C cg23363182 chr2:181467187 NA 0.47 10.26 0.38 5.74e-23 Obesity; BRCA cis rs9393692 0.905 rs6916289 chr6:26289122 A/T cg05868516 chr6:26286170 HIST1H4H 0.49 11.04 0.4 4.82e-26 Educational attainment; BRCA cis rs26949 0.526 rs6887637 chr5:60035640 A/G cg02684056 chr5:59996105 DEPDC1B -0.35 -8.18 -0.31 1.48e-15 Intelligence (multi-trait analysis); BRCA trans rs877282 0.945 rs11253391 chr10:788752 G/A cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs17376456 0.825 rs13357713 chr5:93145423 T/C cg25358565 chr5:93447407 FAM172A 1.17 18.19 0.58 6.98e-60 Diabetic retinopathy; BRCA cis rs4833079 0.562 rs11944291 chr4:38631620 T/G cg18361445 chr4:38666374 KLF3;FLJ13197 0.56 12.01 0.43 4.07e-30 Body mass index; BRCA cis rs35110281 0.805 rs3788062 chr21:44991159 C/T cg21573476 chr21:45109991 RRP1B -0.33 -8.56 -0.32 8.44e-17 Mean corpuscular volume; BRCA cis rs9300255 0.602 rs6488864 chr12:123618362 G/C cg00376283 chr12:123451042 ABCB9 0.54 10.87 0.4 2.21e-25 Neutrophil percentage of white cells; BRCA cis rs2276314 0.857 rs9960670 chr18:33577712 A/G cg05985134 chr18:33552581 C18orf21 0.63 11.13 0.4 2.07e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9420 0.961 rs576859 chr11:57480623 A/C cg19752551 chr11:57585705 CTNND1 0.41 10.44 0.38 1.12e-23 Schizophrenia; BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg04267008 chr7:1944627 MAD1L1 0.59 12.45 0.44 5.41e-32 Bipolar disorder and schizophrenia; BRCA cis rs2832191 0.671 rs68101501 chr21:30513229 G/T cg24692254 chr21:30365293 RNF160 -0.46 -10.21 -0.37 9.05e-23 Dental caries; BRCA trans rs1493916 0.837 rs8088362 chr18:31413016 A/G cg15819921 chr19:927150 ARID3A -0.41 -7.96 -0.3 7.78e-15 Life satisfaction; BRCA trans rs8073060 0.586 rs226089 chr17:34016935 C/T cg19694781 chr19:47549865 TMEM160 -1.06 -21.42 -0.65 4.16e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2070488 0.560 rs1381798 chr3:38437471 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.53 -11.03 -0.4 4.97e-26 Electrocardiographic conduction measures; BRCA cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg01939980 chr4:1354348 KIAA1530 0.29 7.96 0.3 7.95e-15 Obesity-related traits; BRCA cis rs801193 1.000 rs2707856 chr7:66211010 A/T cg18876405 chr7:65276391 NA 0.62 15.39 0.52 1.1e-45 Aortic root size; BRCA cis rs9487051 0.802 rs9487039 chr6:109610163 A/T cg12927641 chr6:109611667 NA -0.42 -10.81 -0.39 4.03e-25 Reticulocyte fraction of red cells; BRCA cis rs7267979 0.903 rs6107015 chr20:25216764 G/A cg08601574 chr20:25228251 PYGB 0.41 9.5 0.35 4.11e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17270561 0.609 rs1165156 chr6:25792978 T/C cg17691542 chr6:26056736 HIST1H1C 0.43 9.27 0.34 2.89e-19 Iron status biomarkers; BRCA cis rs2303745 0.589 rs891018 chr19:17396761 C/T cg10664184 chr19:17420304 DDA1 -0.37 -10.36 -0.38 2.32e-23 Systemic lupus erythematosus; BRCA cis rs4665809 0.878 rs4143538 chr2:26290178 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.75 -13.29 -0.47 9.33e-36 Gut microbiome composition (summer); BRCA cis rs8177253 0.665 rs7646118 chr3:133450039 C/T cg11941060 chr3:133502564 NA -0.33 -7.82 -0.3 2.2e-14 Iron status biomarkers; BRCA cis rs4689592 0.503 rs2292461 chr4:7058473 C/T cg19539972 chr4:7069911 GRPEL1 0.59 12.06 0.43 2.55e-30 Monocyte percentage of white cells; BRCA cis rs6750047 0.625 rs336037 chr2:38261124 T/C cg07380506 chr2:38303506 CYP1B1 -0.48 -10.44 -0.38 1.19e-23 Cutaneous malignant melanoma;Melanoma; BRCA cis rs9420 0.816 rs674094 chr11:57665336 A/C cg19752551 chr11:57585705 CTNND1 0.45 10.33 0.38 3.22e-23 Schizophrenia; BRCA cis rs793571 0.590 rs474875 chr15:59086703 A/C cg05156742 chr15:59063176 FAM63B 0.55 11.5 0.41 5.72e-28 Schizophrenia; BRCA cis rs6724607 0.905 rs10173771 chr2:191439248 T/C cg21644426 chr2:191273491 MFSD6 0.45 11.46 0.41 8.71e-28 Pulse pressure; BRCA cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.65 10.2 0.37 9.55e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1552244 0.935 rs35148833 chr3:10116937 C/A cg00166722 chr3:10149974 C3orf24 0.65 12.73 0.45 3.17e-33 Alzheimer's disease; BRCA cis rs11098499 0.789 rs1980024 chr4:120253047 C/T cg09307838 chr4:120376055 NA 0.64 14.05 0.49 2.77e-39 Corneal astigmatism; BRCA cis rs3768617 0.510 rs10737245 chr1:183100884 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.863 rs3775848 chr4:120447724 C/T cg09307838 chr4:120376055 NA 0.69 13.97 0.48 6.93e-39 Corneal astigmatism; BRCA cis rs2836974 0.584 rs7276774 chr21:40628725 T/G cg06238570 chr21:40685208 BRWD1 -0.42 -8.65 -0.32 4.11e-17 Cognitive function; BRCA cis rs763121 0.853 rs5750662 chr22:39072472 G/A cg14440974 chr22:39074834 NA -0.38 -9.13 -0.34 8.96e-19 Menopause (age at onset); BRCA cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.42 8.09 0.3 2.94e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg12463550 chr7:65579703 CRCP -0.38 -8.24 -0.31 1.01e-15 Aortic root size; BRCA cis rs2535633 0.631 rs11915851 chr3:53096047 C/T cg11645453 chr3:52864694 ITIH4 0.34 8.38 0.31 3.35e-16 Body mass index; BRCA cis rs4808199 0.895 rs4808194 chr19:19435680 T/G cg03709012 chr19:19516395 GATAD2A 0.98 18.19 0.58 6.69e-60 Nonalcoholic fatty liver disease; BRCA trans rs7618501 1.000 rs1049256 chr3:49763338 T/C cg21582582 chr3:182698605 DCUN1D1 -0.38 -10.12 -0.37 2.05e-22 Intelligence (multi-trait analysis); BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg13397359 chr6:42928475 GNMT -0.76 -18.95 -0.6 6.59e-64 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs34172651 0.517 rs12920774 chr16:24830750 T/C cg04756594 chr16:24857601 SLC5A11 0.46 9.68 0.36 8.82e-21 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.559 rs6119652 chr20:30259445 C/G cg13852791 chr20:30311386 BCL2L1 0.95 23.01 0.67 8.32e-86 Mean corpuscular hemoglobin; BRCA cis rs9733 0.596 rs17606613 chr1:150683015 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs2576037 0.583 rs680018 chr18:44409167 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.86 -0.39 2.47e-25 Personality dimensions; BRCA cis rs921968 0.613 rs1344642 chr2:219555262 G/A cg02176678 chr2:219576539 TTLL4 -0.39 -10.48 -0.38 8.33e-24 Mean corpuscular hemoglobin concentration; BRCA cis rs4409675 0.597 rs1467464 chr1:28211650 T/C cg23691781 chr1:28212827 C1orf38 0.33 11.03 0.4 5.03e-26 Corneal astigmatism; BRCA cis rs16867321 0.950 rs12477283 chr2:181501355 G/T cg23363182 chr2:181467187 NA -0.44 -8.33 -0.31 5.05e-16 Obesity; BRCA cis rs11719291 0.584 rs13080725 chr3:49076092 G/A cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 Cognitive function; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg13880726 chr7:1868755 MAD1L1 0.51 10.01 0.37 5.32e-22 Bipolar disorder and schizophrenia; BRCA cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.790 rs9386141 chr6:146268623 T/A cg23711669 chr6:146136114 FBXO30 -0.67 -15.71 -0.53 2.78e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.903 rs11812523 chr10:915638 C/T cg20503657 chr10:835505 NA 1.05 18.42 0.59 4.49e-61 Eosinophil percentage of granulocytes; BRCA cis rs801193 1.000 rs3778909 chr7:66255646 G/C cg18876405 chr7:65276391 NA 0.61 15.07 0.51 3.99e-44 Aortic root size; BRCA cis rs10504229 0.813 rs6999878 chr8:58197243 C/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.11 -0.34 1.01e-18 Developmental language disorder (linguistic errors); BRCA cis rs965469 1.000 rs6037590 chr20:3374085 G/A cg25506879 chr20:3388711 C20orf194 -0.55 -10.55 -0.39 4.41e-24 IFN-related cytopenia; BRCA cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs9733 0.596 rs12063547 chr1:150674053 G/T cg18016565 chr1:150552671 MCL1 -0.35 -8.4 -0.32 2.79e-16 Tonsillectomy; BRCA cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.2 -0.34 5.21e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg18402987 chr7:1209562 NA 0.46 8.8 0.33 1.26e-17 Longevity;Endometriosis; BRCA cis rs897984 0.609 rs4889609 chr16:31026427 A/G cg02466173 chr16:30829666 NA -0.43 -9.75 -0.36 4.92e-21 Dementia with Lewy bodies; BRCA cis rs690037 0.641 rs538525 chr3:16376279 A/G cg23474789 chr3:16306055 DPH3;OXNAD1 0.4 8.38 0.31 3.47e-16 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); BRCA trans rs1945213 0.694 rs7131381 chr11:55858158 T/G cg15704280 chr7:45808275 SEPT13 0.65 11.44 0.41 1.06e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs12824058 0.831 rs11609362 chr12:130810526 T/C cg23887609 chr12:130822674 PIWIL1 0.43 9.33 0.35 1.71e-19 Menopause (age at onset); BRCA cis rs6582630 0.555 rs10785443 chr12:38463792 A/C cg13010199 chr12:38710504 ALG10B 0.43 9.1 0.34 1.14e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs68170813 0.559 rs78888729 chr7:106940957 G/C cg02696742 chr7:106810147 HBP1 -0.53 -8.59 -0.32 6.47e-17 Coronary artery disease; BRCA cis rs751728 0.717 rs3763258 chr6:33773744 A/G cg15252951 chr6:33757062 LEMD2 0.37 8.51 0.32 1.24e-16 Crohn's disease; BRCA cis rs4808199 0.793 rs12459676 chr19:19425141 A/T cg03709012 chr19:19516395 GATAD2A 0.99 17.61 0.57 6.6e-57 Nonalcoholic fatty liver disease; BRCA trans rs9325144 0.560 rs11183046 chr12:38655270 A/T cg23762105 chr12:34175262 ALG10 0.34 7.96 0.3 7.76e-15 Morning vs. evening chronotype; BRCA cis rs600806 0.815 rs10858088 chr1:109923586 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.22 0.31 1.14e-15 Intelligence (multi-trait analysis); BRCA cis rs4308124 0.708 rs28766030 chr2:111962429 T/C cg04571233 chr2:111982156 NA -0.45 -9.67 -0.36 9.67e-21 Vitiligo; BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.06 0.34 1.54e-18 Tonsillectomy; BRCA cis rs7666738 0.791 rs13149968 chr4:99070262 G/T cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.5 15.31 0.52 2.78e-45 Intelligence (multi-trait analysis); BRCA cis rs2033711 0.870 rs11669741 chr19:58960481 C/T cg00825309 chr19:58991885 ZNF446 0.63 14.2 0.49 5.47e-40 Uric acid clearance; BRCA cis rs9914988 0.887 rs9895625 chr17:27108516 A/G cg20469991 chr17:27169893 C17orf63 -0.44 -8.48 -0.32 1.51e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs919433 0.963 rs13033821 chr2:198173536 T/G cg10820045 chr2:198174542 NA -0.38 -7.87 -0.3 1.49e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg24829409 chr8:58192753 C8orf71 -0.45 -8.8 -0.33 1.32e-17 Developmental language disorder (linguistic errors); BRCA cis rs6973256 0.637 rs12539993 chr7:133418799 C/T cg07491979 chr7:133331646 EXOC4 0.35 7.88 0.3 1.43e-14 Intelligence (multi-trait analysis); BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg03885332 chr11:832357 CD151 -0.32 -8.91 -0.33 5.18e-18 Mean platelet volume; BRCA cis rs7586673 0.964 rs34444368 chr2:161954217 G/A cg08807892 chr2:162101083 NA 0.47 8.84 0.33 9.17e-18 Intelligence (multi-trait analysis); BRCA cis rs7918232 0.882 rs6415983 chr10:27357211 A/G cg14442939 chr10:27389572 ANKRD26 0.62 10.37 0.38 2.16e-23 Breast cancer; BRCA cis rs96067 0.805 rs4652902 chr1:36612955 C/A cg24686825 chr1:36642396 MAP7D1 -0.49 -8.95 -0.33 3.7e-18 Corneal structure; BRCA trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.96e-15 Corneal astigmatism; BRCA cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg16339924 chr4:17578868 LAP3 0.61 15.0 0.51 8.07e-44 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13082711 0.911 rs13078798 chr3:27445971 A/G cg02860705 chr3:27208620 NA -0.51 -10.23 -0.38 7.43e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6684514 1.000 rs2273832 chr1:156233143 A/G cg16558208 chr1:156270281 VHLL 0.37 8.07 0.3 3.41e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg11833968 chr6:79620685 NA -0.44 -9.81 -0.36 2.92e-21 Intelligence (multi-trait analysis); BRCA cis rs7412746 0.597 rs868751 chr1:150669414 T/G cg17724175 chr1:150552817 MCL1 0.26 8.49 0.32 1.41e-16 Melanoma; BRCA trans rs3812049 0.737 rs790154 chr5:127501235 A/G cg16011800 chr17:1958478 HIC1 -0.51 -8.43 -0.32 2.28e-16 Lymphocyte counts;Red cell distribution width; BRCA cis rs7301826 0.651 rs1554807 chr12:131280417 C/T cg11011512 chr12:131303247 STX2 -0.52 -13.75 -0.48 7.06e-38 Plasma plasminogen activator levels; BRCA cis rs514406 0.727 rs61768342 chr1:53217028 G/A cg27535305 chr1:53392650 SCP2 0.32 7.93 0.3 9.7e-15 Monocyte count; BRCA cis rs3793683 0.965 rs3829131 chr10:134564627 A/G cg27286337 chr10:134555280 INPP5A -0.85 -20.85 -0.64 4.56e-74 Migraine; BRCA cis rs9790314 0.690 rs6799130 chr3:160847801 C/G cg03342759 chr3:160939853 NMD3 -0.53 -11.44 -0.41 1.09e-27 Morning vs. evening chronotype; BRCA cis rs3733585 0.699 rs6449179 chr4:9969117 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.42 -0.38 1.36e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1506636 1.000 rs689341 chr7:123403974 C/A cg03229431 chr7:123269106 ASB15 0.61 13.57 0.47 4.64e-37 Plateletcrit;Platelet count; BRCA cis rs6820391 0.816 rs4864801 chr4:54442182 C/T cg04173182 chr4:54446035 LNX1 0.49 10.51 0.38 6.02e-24 Cervical artery dissection; BRCA trans rs208520 0.690 rs2144081 chr6:66824972 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.79 -0.64 1.07e-73 Exhaled nitric oxide output; BRCA cis rs832540 0.669 rs173764 chr5:56198920 C/T cg12311346 chr5:56204834 C5orf35 -0.56 -11.7 -0.42 8.64e-29 Coronary artery disease; BRCA cis rs2032447 0.670 rs198845 chr6:26107790 A/C cg03264133 chr6:25882463 NA -0.42 -8.89 -0.33 6.14e-18 Intelligence (multi-trait analysis); BRCA cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg23306229 chr2:178417860 TTC30B -0.52 -8.04 -0.3 4.22e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs561341 0.941 rs4525554 chr17:30312819 T/C cg23018236 chr17:30244563 NA -0.61 -10.05 -0.37 3.63e-22 Hip circumference adjusted for BMI; BRCA cis rs2108225 0.837 rs6959729 chr7:107446180 A/C cg18560240 chr7:107437656 SLC26A3 -0.53 -11.15 -0.4 1.75e-26 Ulcerative colitis; BRCA cis rs7552404 0.727 rs6683437 chr1:76316619 G/A cg22875332 chr1:76189707 ACADM 0.61 11.51 0.41 5.23e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7772486 0.875 rs2777477 chr6:146305491 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.63 0.5 4.95e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs11252926 0.931 rs12358336 chr10:566981 A/T cg08603382 chr10:743973 NA -0.45 -8.39 -0.31 3.19e-16 Psychosis in Alzheimer's disease; BRCA cis rs10504229 0.683 rs34859456 chr8:58117722 A/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs1538970 1.000 rs1538970 chr1:45847562 G/A cg05343316 chr1:45956843 TESK2 0.59 12.18 0.43 8.1e-31 Platelet count; BRCA cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.83 -0.3 1.98e-14 Electroencephalogram traits; BRCA cis rs314370 0.818 rs13245899 chr7:100497131 A/G cg10426581 chr7:100472382 SRRT 0.65 11.33 0.41 3.14e-27 Resting heart rate; BRCA trans rs1997103 0.954 rs6593222 chr7:55372932 A/C cg20935933 chr6:143382018 AIG1 0.6 11.43 0.41 1.16e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7772486 0.875 rs10457794 chr6:146415608 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 3.96e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs911119 1.000 rs6048956 chr20:23609301 C/T cg16589663 chr20:23618590 CST3 0.45 8.5 0.32 1.35e-16 Chronic kidney disease; BRCA trans rs1005277 0.505 rs7069702 chr10:38247359 G/T cg17830980 chr10:43048298 ZNF37B 0.43 10.12 0.37 1.95e-22 Extrinsic epigenetic age acceleration; BRCA trans rs8073060 0.586 rs3859284 chr17:34012792 C/T cg19694781 chr19:47549865 TMEM160 -1.06 -21.56 -0.65 7.18e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg04267008 chr7:1944627 MAD1L1 0.41 9.23 0.34 4.01e-19 Bipolar disorder and schizophrenia; BRCA cis rs11252926 0.603 rs11252670 chr10:529152 A/G cg18196295 chr10:418757 DIP2C -0.44 -9.99 -0.37 6.42e-22 Psychosis in Alzheimer's disease; BRCA trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg11707556 chr5:10655725 ANKRD33B 0.43 9.52 0.35 3.53e-20 Coronary artery disease; BRCA cis rs9291683 0.595 rs35501905 chr4:10053431 C/T cg02734326 chr4:10020555 SLC2A9 0.38 7.97 0.3 7.1e-15 Bone mineral density; BRCA cis rs1451375 0.698 rs11238226 chr7:50645827 A/G cg18232548 chr7:50535776 DDC 0.38 8.96 0.33 3.63e-18 Malaria; BRCA cis rs2404602 0.716 rs8030411 chr15:76699855 A/G cg23625390 chr15:77176239 SCAPER 0.4 9.5 0.35 4.06e-20 Blood metabolite levels; BRCA cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg00750074 chr16:89608354 SPG7 -0.42 -11.34 -0.41 2.69e-27 Multiple myeloma (IgH translocation); BRCA cis rs965469 0.948 rs6139079 chr20:3314374 C/T cg25506879 chr20:3388711 C20orf194 0.5 9.55 0.35 2.62e-20 IFN-related cytopenia; BRCA cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg12386194 chr3:101231763 SENP7 0.45 9.71 0.36 6.78e-21 Colorectal cancer; BRCA cis rs13190036 1.000 rs35535623 chr5:176629296 A/G cg06733329 chr5:176740039 MXD3 0.46 8.27 0.31 7.9e-16 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA trans rs9291683 0.530 rs882223 chr4:9981625 A/C cg26043149 chr18:55253948 FECH 0.39 8.78 0.33 1.46e-17 Bone mineral density; BRCA cis rs1577917 1.000 rs1857964 chr6:86635994 A/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -7.82 -0.3 2.25e-14 Response to antipsychotic treatment; BRCA cis rs9323205 0.953 rs11623710 chr14:51694261 C/T cg23942311 chr14:51606299 NA -0.43 -8.76 -0.33 1.69e-17 Cancer; BRCA cis rs8010715 0.785 rs2877611 chr14:24595430 C/T cg23112188 chr14:24563095 PCK2 -0.33 -8.18 -0.31 1.57e-15 IgG glycosylation; BRCA cis rs4820539 1.000 rs4822361 chr22:23482718 A/G cg14186256 chr22:23484241 RTDR1 -0.78 -24.3 -0.69 6.98e-93 Bone mineral density; BRCA cis rs10504229 0.953 rs59265461 chr8:58189701 A/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.52 -0.44 2.53e-32 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.62e-20 Total body bone mineral density; BRCA cis rs4665809 1.000 rs750452 chr2:26324995 G/A cg25036284 chr2:26402008 FAM59B -0.63 -10.55 -0.39 4.14e-24 Gut microbiome composition (summer); BRCA trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg15704280 chr7:45808275 SEPT13 0.6 10.23 0.38 7.19e-23 Axial length; BRCA cis rs7267979 0.966 rs2257233 chr20:25265984 A/C cg24626310 chr20:25276739 ABHD12;PYGB -0.36 -10.0 -0.37 5.81e-22 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg06532163 chr17:45867833 NA 0.37 7.81 0.3 2.41e-14 IgG glycosylation; BRCA trans rs7618501 0.602 rs2013208 chr3:50129399 C/T cg21659725 chr3:3221576 CRBN -0.44 -10.77 -0.39 5.9e-25 Intelligence (multi-trait analysis); BRCA cis rs875971 0.522 rs2008188 chr7:65429013 G/C cg18876405 chr7:65276391 NA 0.7 18.55 0.59 9.27e-62 Aortic root size; BRCA cis rs17685 0.753 rs4398845 chr7:75716781 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.9 -0.33 5.69e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7474896 0.583 rs10764144 chr10:37975732 G/C cg25427524 chr10:38739819 LOC399744 -0.52 -9.46 -0.35 5.68e-20 Obesity (extreme); BRCA cis rs6542838 0.580 rs1607256 chr2:99543444 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.05 -0.34 1.66e-18 Fear of minor pain; BRCA cis rs7715806 0.500 rs17649362 chr5:75008958 C/T cg19683494 chr5:74908142 NA 0.53 8.59 0.32 6.64e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17270561 0.585 rs9393663 chr6:25741033 A/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.76 0.33 1.76e-17 Iron status biomarkers; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg14196790 chr5:131705035 SLC22A5 -0.33 -8.72 -0.33 2.36e-17 Breast cancer; BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg00106254 chr7:1943704 MAD1L1 -0.42 -10.27 -0.38 5.37e-23 Bipolar disorder and schizophrenia; BRCA cis rs7086627 0.515 rs10887903 chr10:82210641 C/T cg00277334 chr10:82204260 NA -0.85 -25.09 -0.7 3.28e-97 Post bronchodilator FEV1; BRCA cis rs7589728 0.563 rs75606549 chr2:88466069 T/C cg04511125 chr2:88470314 THNSL2 0.95 13.67 0.48 1.66e-37 Plasma clusterin levels; BRCA cis rs4853036 0.540 rs10204989 chr2:69999727 T/C cg02498382 chr2:70120550 SNRNP27 -0.42 -7.91 -0.3 1.17e-14 Colorectal or endometrial cancer; BRCA trans rs2262909 1.000 rs2078089 chr19:22209753 A/T cg17074339 chr11:11642133 GALNTL4 -0.41 -7.81 -0.3 2.42e-14 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs208520 0.633 rs7738469 chr6:66807446 T/C cg07460842 chr6:66804631 NA -1.0 -20.11 -0.62 4.5e-70 Exhaled nitric oxide output; BRCA cis rs9325144 0.650 rs6582631 chr12:38744135 T/C cg26384229 chr12:38710491 ALG10B 0.5 12.36 0.44 1.24e-31 Morning vs. evening chronotype; BRCA cis rs9435341 0.965 rs55924375 chr1:107566690 C/A cg09367891 chr1:107599246 PRMT6 0.51 9.47 0.35 5.52e-20 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs4819052 0.851 rs1999333 chr21:46670401 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.42 0.35 8.31e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4722585 0.533 rs2158359 chr7:26193309 A/C cg07876897 chr7:26191696 NFE2L3 -0.4 -8.73 -0.33 2.24e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs4363385 0.597 rs55667413 chr1:152976849 G/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.78 -0.36 3.71e-21 Inflammatory skin disease; BRCA cis rs6460942 0.915 rs80345607 chr7:12442249 T/C cg10578991 chr7:12443926 VWDE -0.55 -7.9 -0.3 1.2e-14 Coronary artery disease; BRCA cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg06238570 chr21:40685208 BRWD1 -0.39 -7.99 -0.3 6.49e-15 Menarche (age at onset); BRCA cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg26408565 chr15:76604113 ETFA -0.47 -10.13 -0.37 1.87e-22 Blood metabolite levels; BRCA cis rs858239 0.600 rs28499396 chr7:23124098 A/G cg23682824 chr7:23144976 KLHL7 0.45 11.83 0.42 2.53e-29 Cerebrospinal fluid biomarker levels; BRCA trans rs61931739 0.517 rs860950 chr12:34104376 C/G cg13010199 chr12:38710504 ALG10B 0.4 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs2204008 0.713 rs2320522 chr12:38251438 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg23978390 chr7:1156363 C7orf50 0.51 11.88 0.43 1.53e-29 Longevity;Endometriosis; BRCA cis rs4689592 0.587 rs3822269 chr4:7069901 T/C cg06697600 chr4:7070879 GRPEL1 -0.55 -10.79 -0.39 4.71e-25 Monocyte percentage of white cells; BRCA cis rs4363385 0.747 rs1055935 chr1:152975941 C/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.54 -0.35 2.94e-20 Inflammatory skin disease; BRCA cis rs8062405 1.000 rs4788101 chr16:28867804 C/T cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs12142240 0.667 rs12062 chr1:46830447 G/T cg10495392 chr1:46806563 NSUN4 -0.44 -8.17 -0.31 1.65e-15 Menopause (age at onset); BRCA cis rs7091068 0.518 rs913045 chr10:95431535 C/T cg20715218 chr10:95462985 C10orf4 0.48 10.3 0.38 4.04e-23 Urinary tract infection frequency; BRCA cis rs9487051 0.646 rs7773490 chr6:109623048 T/C cg01475377 chr6:109611718 NA -0.4 -8.76 -0.33 1.79e-17 Reticulocyte fraction of red cells; BRCA cis rs6912958 1.000 rs2207144 chr6:88150816 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.96 -0.33 3.58e-18 Monocyte percentage of white cells; BRCA cis rs12477438 0.561 rs2084988 chr2:99655755 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.39 -0.44 9.32e-32 Chronic sinus infection; BRCA cis rs9291683 0.527 rs3822247 chr4:10094671 G/A cg00071950 chr4:10020882 SLC2A9 -0.52 -12.12 -0.43 1.45e-30 Bone mineral density; BRCA cis rs10189230 0.935 rs3770146 chr2:222344196 G/A cg14652038 chr2:222343519 EPHA4 0.47 12.53 0.44 2.38e-32 Urate levels in lean individuals; BRCA cis rs7659604 0.702 rs58649165 chr4:122693752 C/A cg20573242 chr4:122745356 CCNA2 0.42 9.35 0.35 1.44e-19 Type 2 diabetes; BRCA cis rs6831352 0.703 rs4235435 chr4:100039578 C/T cg12011299 chr4:100065546 ADH4 0.42 10.56 0.39 3.95e-24 Alcohol dependence; BRCA cis rs6733011 0.531 rs13004923 chr2:99497561 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.37 -8.53 -0.32 1.03e-16 Bipolar disorder; BRCA cis rs2019137 0.936 rs731834 chr2:113957198 A/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.61 -12.92 -0.45 4.51e-34 Lymphocyte counts; BRCA cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg24675658 chr1:53192096 ZYG11B 0.56 12.76 0.45 2.24e-33 Monocyte count; BRCA cis rs3916 0.911 rs3999408 chr12:121167387 C/T cg21892295 chr12:121157589 UNC119B -0.37 -9.66 -0.36 1.04e-20 Urinary metabolites (H-NMR features); BRCA cis rs2304069 0.826 rs245076 chr5:149350648 C/T cg12661370 chr5:149340060 SLC26A2 0.5 9.36 0.35 1.39e-19 HIV-1 control; BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 18.46 0.59 2.64e-61 Alzheimer's disease; BRCA cis rs9381107 0.505 rs1001384 chr6:9485556 G/A cg14735645 chr6:9486422 NA -0.44 -8.67 -0.32 3.46e-17 Nonsyndromic cleft lip with cleft palate; BRCA cis rs2153535 0.526 rs1796689 chr6:8536433 A/C cg23788917 chr6:8435910 SLC35B3 0.48 10.26 0.38 5.62e-23 Motion sickness; BRCA cis rs6547741 0.935 rs4665384 chr2:27848397 A/G cg27432699 chr2:27873401 GPN1 0.42 8.9 0.33 5.55e-18 Oral cavity cancer; BRCA cis rs7613875 0.620 rs11721204 chr3:49982765 C/T cg24110177 chr3:50126178 RBM5 -0.51 -14.22 -0.49 4.4e-40 Body mass index; BRCA cis rs9733 0.818 rs10888388 chr1:150687296 C/T cg13175981 chr1:150552382 MCL1 0.47 10.51 0.38 5.93e-24 Tonsillectomy; BRCA trans rs7618501 0.601 rs2624825 chr3:50154989 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.05 -0.34 1.76e-18 Intelligence (multi-trait analysis); BRCA cis rs9788682 0.747 rs2568488 chr15:78736593 T/A cg24631222 chr15:78858424 CHRNA5 -0.5 -9.95 -0.37 8.52e-22 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.27 0.49 2.6e-40 Motion sickness; BRCA cis rs4665809 0.627 rs35461456 chr2:26482361 C/G cg08470875 chr2:26401718 FAM59B 0.76 11.94 0.43 8.04e-30 Gut microbiome composition (summer); BRCA cis rs12586317 0.534 rs2273157 chr14:35438836 A/G cg05294307 chr14:35346193 BAZ1A -0.6 -11.78 -0.42 4.11e-29 Psoriasis; BRCA cis rs17092148 1.000 rs6058117 chr20:33366905 A/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs12579753 1.000 rs12579753 chr12:82219376 C/T cg07988820 chr12:82153109 PPFIA2 -0.55 -9.2 -0.34 5e-19 Resting heart rate; BRCA cis rs10870270 0.957 rs10870307 chr10:133780610 T/C cg17892150 chr10:133769511 PPP2R2D -0.72 -15.34 -0.52 1.99e-45 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs16958440 1.000 rs2289130 chr18:44626630 T/G cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs514406 0.830 rs533935 chr1:53308807 T/C cg01802117 chr1:53393560 SCP2 -0.34 -8.01 -0.3 5.42e-15 Monocyte count; BRCA cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg15839431 chr19:19639596 YJEFN3 -0.41 -9.08 -0.34 1.35e-18 Bipolar disorder; BRCA cis rs61931739 0.500 rs7298322 chr12:34445489 A/T cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.79e-23 Morning vs. evening chronotype; BRCA trans rs9929218 1.000 rs12448448 chr16:68802516 T/G cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.92 -0.48 1.13e-38 Colorectal cancer; BRCA cis rs2204008 0.805 rs11169513 chr12:37988640 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.0 0.37 5.92e-22 Bladder cancer; BRCA cis rs7824557 1.000 rs7824557 chr8:11104111 C/T cg21775007 chr8:11205619 TDH -0.52 -10.48 -0.38 8.15e-24 Retinal vascular caliber; BRCA cis rs10751667 1.000 rs10902246 chr11:953674 T/C ch.11.42038R chr11:967971 AP2A2 0.58 19.05 0.6 2.01e-64 Alzheimer's disease (late onset); BRCA trans rs3857536 0.673 rs7759888 chr6:66891922 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs17095355 0.901 rs9783184 chr10:111760499 T/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.77 -0.36 4.23e-21 Biliary atresia; BRCA cis rs4319547 0.661 rs10773172 chr12:122939655 G/A cg05707623 chr12:122985044 ZCCHC8 -0.42 -8.67 -0.32 3.47e-17 Body mass index; BRCA cis rs751728 0.687 rs4711355 chr6:33759906 G/T cg25922239 chr6:33757077 LEMD2 0.49 12.31 0.44 2.1e-31 Crohn's disease; BRCA cis rs2075371 1.000 rs2544213 chr7:133982867 G/C cg20476274 chr7:133979776 SLC35B4 0.7 21.4 0.65 5.31e-77 Mean platelet volume; BRCA cis rs4595586 0.545 rs6580892 chr12:39370237 G/C cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs67478160 0.654 rs1535097 chr14:104216649 C/T cg26031613 chr14:104095156 KLC1 -0.42 -8.52 -0.32 1.14e-16 Schizophrenia; BRCA cis rs9309473 1.000 rs7564890 chr2:73641853 T/C cg20560298 chr2:73613845 ALMS1 -0.43 -10.65 -0.39 1.79e-24 Metabolite levels; BRCA cis rs1577917 0.916 rs12203358 chr6:86603224 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -11.91 -0.43 1.15e-29 Response to antipsychotic treatment; BRCA cis rs910316 0.763 rs175036 chr14:75464295 C/T cg08847533 chr14:75593920 NEK9 -0.84 -20.9 -0.64 2.57e-74 Height; BRCA cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg10556349 chr10:835070 NA 0.6 8.41 0.32 2.75e-16 Eosinophil percentage of granulocytes; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg07332563 chr6:291687 DUSP22 0.57 11.72 0.42 6.94e-29 Menopause (age at onset); BRCA cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg27286337 chr10:134555280 INPP5A 0.8 12.94 0.46 3.49e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7043114 0.525 rs2516567 chr9:95187418 C/T cg14631576 chr9:95140430 CENPP -0.32 -7.88 -0.3 1.45e-14 Height; BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg00945666 chr1:160990265 F11R -0.3 -8.65 -0.32 4.27e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs35110281 0.837 rs2838340 chr21:45076373 A/G cg21573476 chr21:45109991 RRP1B -0.32 -8.63 -0.32 4.88e-17 Mean corpuscular volume; BRCA cis rs11098499 0.722 rs1814814 chr4:120258124 C/G cg09307838 chr4:120376055 NA 0.64 14.17 0.49 8.18e-40 Corneal astigmatism; BRCA cis rs11249608 0.703 rs7726601 chr5:178444713 A/G cg21905437 chr5:178450457 ZNF879 -0.48 -9.82 -0.36 2.76e-21 Pubertal anthropometrics; BRCA cis rs7043114 0.507 rs10761154 chr9:95144086 A/G cg14631576 chr9:95140430 CENPP -0.33 -8.33 -0.31 4.77e-16 Height; BRCA cis rs7312933 0.524 rs11181465 chr12:42765098 T/G cg01256987 chr12:42539512 GXYLT1 -0.42 -8.28 -0.31 7.06e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6582630 0.519 rs7305570 chr12:38349285 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.49 0.38 7.33e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.39 8.71 0.33 2.67e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs780096 0.505 rs12475426 chr2:27599132 G/A cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.43 -0.32 2.32e-16 Total body bone mineral density; BRCA cis rs11252926 0.897 rs7092330 chr10:583771 G/C cg08603382 chr10:743973 NA -0.4 -8.06 -0.3 3.65e-15 Psychosis in Alzheimer's disease; BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 18.53 0.59 1.19e-61 Platelet count; BRCA cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.37 0.41 2.1e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs847577 0.540 rs3847055 chr7:97680645 A/G cg24562669 chr7:97807699 LMTK2 -0.41 -9.33 -0.35 1.74e-19 Breast cancer; BRCA cis rs6484504 0.576 rs2616792 chr11:31324298 T/G cg06552810 chr11:31128660 NA 0.39 8.52 0.32 1.16e-16 Red blood cell count; BRCA cis rs4862750 0.837 rs1863404 chr4:187874654 T/C cg10295955 chr4:187884368 NA -0.95 -28.11 -0.74 8.57e-114 Lobe attachment (rater-scored or self-reported); BRCA cis rs8032158 0.963 rs12102020 chr15:56125578 G/A cg02198044 chr15:56286336 NEDD4 -0.38 -9.04 -0.34 1.8e-18 Keloid; BRCA cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg16405210 chr4:1374714 KIAA1530 0.36 7.95 0.3 8.65e-15 Obesity-related traits; BRCA cis rs921968 0.541 rs647990 chr2:219441428 T/C cg02176678 chr2:219576539 TTLL4 0.46 12.16 0.43 9.47e-31 Mean corpuscular hemoglobin concentration; BRCA cis rs6089584 0.888 rs2386555 chr20:60612373 C/T cg13770153 chr20:60521292 NA -0.41 -9.12 -0.34 9.68e-19 Body mass index; BRCA cis rs72766638 0.895 rs11795079 chr9:136930134 T/C cg13789015 chr9:136890014 NCRNA00094 0.58 9.09 0.34 1.19e-18 Mosquito bite size; BRCA cis rs17345786 0.953 rs78645744 chr3:101327789 T/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 13.06 0.46 1.03e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.728 rs17804365 chr8:58151537 C/A cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg03709012 chr19:19516395 GATAD2A 0.74 16.53 0.55 2.31e-51 Tonsillectomy; BRCA cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.64e-23 Motion sickness; BRCA cis rs6545883 0.894 rs2694649 chr2:61573826 G/A cg15711740 chr2:61764176 XPO1 0.52 13.25 0.46 1.42e-35 Tuberculosis; BRCA trans rs6089829 0.962 rs2314130 chr20:61665129 G/T cg17470723 chr8:74884337 TCEB1 0.41 8.88 0.33 6.51e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs28830936 0.510 rs7174099 chr15:42099059 A/G cg17847044 chr15:42102381 MAPKBP1 -0.51 -19.65 -0.61 1.25e-67 Diastolic blood pressure; BRCA cis rs2011503 0.943 rs2965195 chr19:19463032 A/G cg15839431 chr19:19639596 YJEFN3 0.35 7.96 0.3 7.7e-15 Bipolar disorder; BRCA trans rs4714291 0.862 rs2984445 chr6:40069935 C/T cg02267698 chr19:7991119 CTXN1 -0.45 -9.39 -0.35 1.07e-19 Strep throat; BRCA trans rs7746199 0.736 rs13209332 chr6:27520752 T/A cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.88e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs4237845 0.611 rs10877036 chr12:58321650 A/G cg02175503 chr12:58329896 NA -0.75 -18.66 -0.59 2.45e-62 Intelligence (multi-trait analysis); BRCA cis rs2576037 0.526 rs7240239 chr18:44460037 T/C cg19077165 chr18:44547161 KATNAL2 -0.54 -11.61 -0.42 2.14e-28 Personality dimensions; BRCA cis rs6580649 0.943 rs1859444 chr12:48399403 T/C cg05342945 chr12:48394962 COL2A1 -0.49 -9.83 -0.36 2.46e-21 Lung cancer; BRCA cis rs910316 1.000 rs175449 chr14:75590846 A/T cg08847533 chr14:75593920 NEK9 -0.87 -22.33 -0.66 4.66e-82 Height; BRCA cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg04546413 chr19:29218101 NA 0.64 10.9 0.4 1.79e-25 Methadone dose in opioid dependence; BRCA cis rs1580019 0.587 rs34488151 chr7:32548146 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.34 0.31 4.57e-16 Cognitive ability; BRCA cis rs3820928 0.967 rs12622456 chr2:227768868 G/A cg11843606 chr2:227700838 RHBDD1 -0.41 -8.97 -0.33 3.37e-18 Pulmonary function; BRCA cis rs4319547 0.585 rs10846792 chr12:122882374 T/C cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.48 -0.35 4.88e-20 Body mass index; BRCA cis rs7520050 0.966 rs4073846 chr1:46462881 C/T cg24296786 chr1:45957014 TESK2 -0.43 -9.56 -0.35 2.47e-20 Red blood cell count;Reticulocyte count; BRCA cis rs595982 0.559 rs17206714 chr19:49362001 T/A cg15549821 chr19:49342101 PLEKHA4 -0.71 -11.33 -0.41 2.94e-27 Red cell distribution width; BRCA cis rs644799 0.932 rs10831447 chr11:95663017 C/T cg03916912 chr11:95522834 CEP57;FAM76B -0.73 -16.2 -0.54 1.01e-49 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs897984 0.568 rs72799330 chr16:30893555 C/A cg02466173 chr16:30829666 NA -0.47 -9.16 -0.34 6.96e-19 Dementia with Lewy bodies; BRCA cis rs13046373 0.535 rs2226377 chr21:32031915 T/C cg24082983 chr21:31802169 KRTAP13-4 0.34 8.26 0.31 8.39e-16 HDL cholesterol; BRCA cis rs853679 0.517 rs9380061 chr6:28132803 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs72781680 0.898 rs56315094 chr2:23941952 T/C cg20701182 chr2:24300061 SF3B14 0.55 8.19 0.31 1.37e-15 Lymphocyte counts; BRCA cis rs34779708 0.897 rs4934527 chr10:35281118 T/A cg03585969 chr10:35415529 CREM 0.48 10.11 0.37 2.25e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg26536863 chr7:158807979 LOC154822 0.36 8.29 0.31 6.79e-16 Facial morphology (factor 20); BRCA cis rs2014572 0.967 rs8106734 chr19:57763546 C/T cg24459738 chr19:57751996 ZNF805 -0.35 -8.3 -0.31 6.28e-16 Hyperactive-impulsive symptoms; BRCA cis rs7615952 0.512 rs1077621 chr3:125819799 A/G cg18479299 chr3:125709523 NA -0.54 -8.3 -0.31 6.41e-16 Blood pressure (smoking interaction); BRCA cis rs10883723 0.703 rs7898410 chr10:104245858 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 19.86 0.62 1.07e-68 Allergic disease (asthma, hay fever or eczema); BRCA cis rs3820928 0.605 rs4675124 chr2:227802354 G/A cg05526886 chr2:227700861 RHBDD1 -0.42 -8.63 -0.32 4.87e-17 Pulmonary function; BRCA cis rs651907 0.557 rs3094295 chr3:101401995 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.63 15.46 0.52 5.04e-46 Colorectal cancer; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.06 -0.34 1.53e-18 Total body bone mineral density; BRCA cis rs6426558 0.537 rs10495253 chr1:227471820 A/T cg10327440 chr1:227177885 CDC42BPA 0.48 9.6 0.36 1.73e-20 Neutrophil percentage of white cells; BRCA cis rs2249625 0.874 rs1819063 chr6:72908180 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -7.84 -0.3 1.84e-14 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg22105103 chr4:187893119 NA 0.38 11.66 0.42 1.23e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs67460515 0.531 rs1585483 chr3:160843111 G/A cg03342759 chr3:160939853 NMD3 -0.7 -13.73 -0.48 9.24e-38 Parkinson's disease; BRCA cis rs4845875 0.626 rs10864542 chr1:11842144 C/G cg24844545 chr1:11908347 NPPA 0.33 8.26 0.31 8.22e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs9649465 1.000 rs3779260 chr7:123348315 A/G cg04330084 chr7:123175371 IQUB 0.31 8.45 0.32 2e-16 Migraine; BRCA cis rs6570726 0.935 rs7757387 chr6:145816726 G/T cg23711669 chr6:146136114 FBXO30 0.63 14.31 0.49 1.72e-40 Lobe attachment (rater-scored or self-reported); BRCA trans rs1493916 0.870 rs7239173 chr18:31395534 A/T cg27147174 chr7:100797783 AP1S1 -0.58 -11.79 -0.42 3.49e-29 Life satisfaction; BRCA cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg18876405 chr7:65276391 NA 0.55 12.97 0.46 2.45e-34 Aortic root size; BRCA cis rs372883 0.530 rs2832302 chr21:30749793 G/T cg08807101 chr21:30365312 RNF160 -0.35 -7.88 -0.3 1.43e-14 Pancreatic cancer; BRCA cis rs34172651 0.517 rs11862923 chr16:24767303 G/T cg00339695 chr16:24857497 SLC5A11 0.53 11.33 0.41 2.91e-27 Intelligence (multi-trait analysis); BRCA cis rs11971779 0.680 rs111461944 chr7:139077903 G/C cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg14993813 chr1:46806288 NSUN4 -0.47 -9.04 -0.34 1.91e-18 Menopause (age at onset); BRCA cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg01877450 chr7:97915802 BRI3 -0.39 -8.98 -0.33 3.1e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs896854 0.846 rs7845219 chr8:95937502 T/C cg26343298 chr8:95960752 TP53INP1 0.29 8.06 0.3 3.78e-15 Type 2 diabetes; BRCA trans rs61931739 0.534 rs2636082 chr12:34061848 T/A cg13010199 chr12:38710504 ALG10B 0.4 8.08 0.3 3.19e-15 Morning vs. evening chronotype; BRCA cis rs875971 0.660 rs801211 chr7:66015689 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.07 -0.3 3.54e-15 Aortic root size; BRCA cis rs4561483 0.767 rs33633 chr16:11994857 A/C cg08843971 chr16:11963173 GSPT1 -0.54 -12.22 -0.44 5.31e-31 Testicular germ cell tumor; BRCA cis rs829883 0.724 rs1439774 chr12:98907692 C/T cg25150519 chr12:98850993 NA -0.51 -9.37 -0.35 1.25e-19 Colorectal adenoma (advanced); BRCA cis rs6450176 1.000 rs1445887 chr5:53299376 A/T ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.11 -0.51 2.49e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs250677 0.617 rs166106 chr5:148447061 T/C cg12140854 chr5:148520817 ABLIM3 -0.43 -8.77 -0.33 1.65e-17 Breast cancer; BRCA cis rs4880487 1.000 rs4880487 chr10:1246883 C/T cg03183215 chr10:1252341 ADARB2 -0.37 -8.43 -0.32 2.35e-16 Migraine; BRCA trans rs6598955 0.671 rs11247896 chr1:26600483 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs11764590 0.694 rs56072378 chr7:2104364 A/G cg02951883 chr7:2050386 MAD1L1 0.39 8.36 0.31 3.89e-16 Neuroticism; BRCA cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg23583168 chr7:148888333 NA -0.83 -18.43 -0.59 3.78e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg06544989 chr22:39130855 UNC84B 0.34 7.94 0.3 9.19e-15 Menopause (age at onset); BRCA cis rs780096 0.526 rs11127013 chr2:27692973 A/G cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.96 -0.3 8.15e-15 Total body bone mineral density; BRCA cis rs2652834 0.904 rs7175602 chr15:63367032 T/C cg05507819 chr15:63340323 TPM1 -0.57 -10.34 -0.38 2.73e-23 HDL cholesterol; BRCA cis rs7267979 1.000 rs2257988 chr20:25270003 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA trans rs17685 0.753 rs9691174 chr7:75790405 T/C cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg14664628 chr15:75095509 CSK -0.94 -29.63 -0.76 4.61e-122 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg06494592 chr3:125709126 NA -0.54 -8.33 -0.31 4.81e-16 Blood pressure (smoking interaction); BRCA cis rs7789940 0.904 rs61294900 chr7:75937212 A/T cg10167463 chr7:75959203 YWHAG -0.43 -8.42 -0.32 2.55e-16 Multiple sclerosis; BRCA cis rs2235642 0.821 rs2281234 chr16:1602938 A/G cg26528668 chr16:1614120 IFT140 0.4 9.12 0.34 9.7e-19 Coronary artery disease; BRCA cis rs9287719 0.601 rs13427815 chr2:10707985 C/T cg00105475 chr2:10696890 NA 0.47 10.32 0.38 3.5e-23 Prostate cancer; BRCA trans rs11165623 0.564 rs9887897 chr1:96996671 T/C cg10631902 chr5:14652156 NA -0.43 -12.06 -0.43 2.43e-30 Hip circumference;Waist circumference; BRCA cis rs367943 1.000 rs348954 chr5:112821716 A/G cg12552261 chr5:112820674 MCC -0.55 -12.09 -0.43 1.9e-30 Type 2 diabetes; BRCA cis rs7592578 0.679 rs62181019 chr2:191325414 A/G cg10560079 chr2:191398806 TMEM194B -0.65 -12.42 -0.44 6.99e-32 Diastolic blood pressure; BRCA cis rs1865760 0.928 rs9295673 chr6:25912094 T/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.05 0.4 4.27e-26 Height; BRCA cis rs11252926 0.528 rs11252090 chr10:436547 C/T cg16386425 chr10:429943 DIP2C 0.42 8.44 0.32 2.14e-16 Psychosis in Alzheimer's disease; BRCA cis rs6912958 0.559 rs2985039 chr6:88041757 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.43 12.17 0.43 8.18e-31 Monocyte percentage of white cells; BRCA cis rs9814567 1.000 rs6804770 chr3:134230234 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4953076 0.573 rs6544746 chr2:44407985 C/T cg04920474 chr2:44395004 PPM1B 0.47 9.56 0.35 2.58e-20 Height; BRCA cis rs941873 0.869 rs7917610 chr10:81117237 T/C cg09469691 chr10:81107165 PPIF 0.53 11.06 0.4 3.99e-26 Height; BRCA cis rs9487051 0.768 rs463503 chr6:109525757 T/C cg01475377 chr6:109611718 NA -0.43 -10.88 -0.4 2.13e-25 Reticulocyte fraction of red cells; BRCA cis rs9420 0.961 rs12146541 chr11:57508678 G/C cg19752551 chr11:57585705 CTNND1 -0.51 -12.59 -0.45 1.22e-32 Schizophrenia; BRCA cis rs7631605 0.935 rs1558528 chr3:37056990 C/A cg15934958 chr3:37212084 LRRFIP2 0.41 9.57 0.35 2.39e-20 Cerebrospinal P-tau181p levels; BRCA cis rs597539 0.652 rs514296 chr11:68654182 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.71 0.59 1.26e-62 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs9986765 1.000 rs73725075 chr7:142823479 C/A cg22531018 chr7:142981779 TMEM139 0.58 9.74 0.36 5.56e-21 Cancer;Dermatomyositis; BRCA cis rs13082711 0.595 rs4973761 chr3:27358620 T/C cg02860705 chr3:27208620 NA 0.78 14.35 0.49 1.1e-40 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs875971 0.825 rs10281499 chr7:66048966 A/G cg11764359 chr7:65958608 NA -0.75 -16.67 -0.55 4.5e-52 Aortic root size; BRCA cis rs9649465 0.967 rs11765790 chr7:123293152 A/C cg03229431 chr7:123269106 ASB15 -0.34 -7.81 -0.3 2.42e-14 Migraine; BRCA trans rs2204008 0.744 rs11519905 chr12:38222959 G/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs875971 0.825 rs7384021 chr7:66077904 A/G cg11764359 chr7:65958608 NA -0.75 -16.5 -0.55 3.37e-51 Aortic root size; BRCA trans rs3857536 0.741 rs9363556 chr6:66934399 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.12 -0.31 2.43e-15 Blood trace element (Cu levels); BRCA cis rs11971779 0.584 rs10236055 chr7:139069991 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA cis rs1448094 0.527 rs1900700 chr12:86232166 C/T cg02569458 chr12:86230093 RASSF9 0.32 7.95 0.3 8.28e-15 Major depressive disorder; BRCA cis rs4689592 0.554 rs3951346 chr4:7073321 C/T cg02503808 chr4:7069936 GRPEL1 0.78 17.92 0.58 1.66e-58 Monocyte percentage of white cells; BRCA cis rs11758351 0.587 rs16891466 chr6:26235737 G/A cg01420254 chr6:26195488 NA 0.55 8.54 0.32 9.51e-17 Gout;Renal underexcretion gout; BRCA cis rs2762353 0.935 rs2328895 chr6:25802083 C/T cg03264133 chr6:25882463 NA -0.49 -11.02 -0.4 5.68e-26 Blood metabolite levels; BRCA cis rs17001868 0.568 rs470113 chr22:40729614 A/G cg07138101 chr22:40742427 ADSL 0.53 9.12 0.34 9.74e-19 Mammographic density (dense area); BRCA cis rs1577917 1.000 rs10944169 chr6:86683036 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.25 -0.41 6.69e-27 Response to antipsychotic treatment; BRCA cis rs5750830 0.649 rs4384886 chr22:39793766 C/T cg01416388 chr22:39784598 NA -0.38 -7.89 -0.3 1.3e-14 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg22800045 chr5:56110881 MAP3K1 0.68 12.8 0.45 1.42e-33 Initial pursuit acceleration; BRCA cis rs10479542 0.784 rs6896940 chr5:178985994 G/C cg00080972 chr5:178986291 RUFY1 0.53 14.96 0.51 1.27e-43 Lung cancer; BRCA cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg00071950 chr4:10020882 SLC2A9 -0.43 -9.96 -0.37 8.02e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs870825 0.790 rs12513128 chr4:185576729 G/C cg04058563 chr4:185651563 MLF1IP 0.66 11.06 0.4 3.92e-26 Blood protein levels; BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.17 -0.34 6.4e-19 Total body bone mineral density; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg24846343 chr22:24311635 DDTL 0.44 10.63 0.39 2.04e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs8114671 0.869 rs2145559 chr20:33651725 G/A cg07148914 chr20:33460835 GGT7 -0.43 -9.16 -0.34 7.16e-19 Height; BRCA cis rs7659604 0.676 rs4077102 chr4:122699830 A/G cg20573242 chr4:122745356 CCNA2 0.47 10.32 0.38 3.35e-23 Type 2 diabetes; BRCA cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg04586622 chr2:25135609 ADCY3 0.45 11.42 0.41 1.34e-27 Body mass index; BRCA cis rs7539409 0.651 rs979757 chr1:84296605 T/C cg10977910 chr1:84465055 TTLL7 0.61 9.31 0.35 2.04e-19 Alzheimer's disease; BRCA cis rs12477438 0.798 rs2045057 chr2:99684929 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs13191362 0.935 rs13193473 chr6:162966852 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 11.5 0.41 6.17e-28 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.02 0.4 5.6e-26 Bipolar disorder; BRCA cis rs9811920 0.683 rs793502 chr3:99588417 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.45 10.85 0.39 2.67e-25 Axial length; BRCA cis rs7666738 0.830 rs34890015 chr4:99023769 A/T cg17366294 chr4:99064904 C4orf37 0.46 10.86 0.39 2.42e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs55882075 0.750 rs13184690 chr5:179146993 T/C cg14593053 chr5:179126677 CANX 0.48 12.75 0.45 2.51e-33 Monocyte percentage of white cells; BRCA cis rs1707322 0.662 rs11211160 chr1:46146229 T/A cg03146154 chr1:46216737 IPP 0.51 11.41 0.41 1.39e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7818345 0.737 rs17407149 chr8:19274848 A/G cg11303988 chr8:19266685 CSGALNACT1 0.31 7.96 0.3 7.66e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs7385804 0.796 rs221801 chr7:100290031 C/A cg16850897 chr7:100343110 ZAN 0.35 8.08 0.3 3.16e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs12973672 1.000 rs28365136 chr19:35769561 T/G cg12095397 chr19:35769544 USF2 0.38 8.38 0.31 3.28e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg13902645 chr11:5959945 NA -0.54 -10.85 -0.39 2.78e-25 DNA methylation (variation); BRCA trans rs6582630 0.502 rs11520279 chr12:38360871 A/G cg06521331 chr12:34319734 NA -0.44 -8.35 -0.31 4.37e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg24977027 chr2:88469347 THNSL2 0.57 9.58 0.35 2.04e-20 Plasma clusterin levels; BRCA cis rs2455601 0.882 rs10840139 chr11:8894838 T/G cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -8.1 -0.31 2.84e-15 Schizophrenia; BRCA cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg26597838 chr10:835615 NA 0.9 14.09 0.49 1.77e-39 Eosinophil percentage of granulocytes; BRCA cis rs9420 0.961 rs10896647 chr11:57571883 C/T cg19752551 chr11:57585705 CTNND1 -0.5 -12.35 -0.44 1.41e-31 Schizophrenia; BRCA cis rs7618915 0.570 rs13068293 chr3:52672167 C/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.36e-31 Bipolar disorder; BRCA cis rs11098499 0.954 rs2306455 chr4:120421969 G/A cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.47e-45 Corneal astigmatism; BRCA cis rs6684514 1.000 rs12045339 chr1:156294211 C/T cg16558208 chr1:156270281 VHLL 0.35 8.1 0.31 2.72e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs1552244 0.882 rs17050672 chr3:10025463 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -9.72 -0.36 6.48e-21 Alzheimer's disease; BRCA cis rs3771570 1.000 rs55634485 chr2:242268994 T/C cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA trans rs6479891 1.000 rs7099425 chr10:64960717 C/T cg14819942 chr15:35414228 NA -0.32 -8.17 -0.31 1.66e-15 Arthritis (juvenile idiopathic); BRCA cis rs9790314 0.905 rs7633186 chr3:161003124 A/G cg03342759 chr3:160939853 NMD3 -0.66 -14.31 -0.49 1.77e-40 Morning vs. evening chronotype; BRCA cis rs11997175 0.846 rs34860600 chr8:33761566 C/A ch.8.33884649F chr8:33765107 NA 0.5 12.37 0.44 1.21e-31 Body mass index; BRCA cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg03433033 chr1:76189801 ACADM -0.47 -9.86 -0.36 1.94e-21 Daytime sleep phenotypes; BRCA cis rs4919694 1.000 rs12266291 chr10:104806884 G/A cg04362960 chr10:104952993 NT5C2 0.94 14.5 0.5 2.26e-41 Arsenic metabolism; BRCA trans rs877282 0.891 rs11253406 chr10:796297 G/A cg22713356 chr15:30763199 NA 1.41 28.52 0.75 5.26e-116 Uric acid levels; BRCA cis rs7086627 0.515 rs10887905 chr10:82210855 A/T cg01528321 chr10:82214614 TSPAN14 0.64 14.52 0.5 1.65e-41 Post bronchodilator FEV1; BRCA cis rs3096299 0.967 rs2965932 chr16:89477051 C/T cg00750074 chr16:89608354 SPG7 0.34 9.0 0.34 2.53e-18 Multiple myeloma (IgH translocation); BRCA cis rs10484885 0.824 rs72921954 chr6:90586656 A/G cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.52 -0.35 3.48e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs34779708 0.931 rs12768019 chr10:35389843 T/C cg03585969 chr10:35415529 CREM 0.56 11.54 0.42 3.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2964802 0.505 rs13179252 chr5:10805662 A/G cg14521931 chr5:10832172 NA -0.58 -13.03 -0.46 1.38e-34 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs12497850 0.931 rs6414613 chr3:49035885 C/T cg07636037 chr3:49044803 WDR6 0.98 29.32 0.76 2.26e-120 Parkinson's disease; BRCA cis rs12477438 0.765 rs6749059 chr2:99591021 G/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.77 -18.93 -0.6 8.81e-64 Chronic sinus infection; BRCA trans rs1351696 1 rs1351696 chr11:48382471 A/G cg15704280 chr7:45808275 SEPT13 -0.55 -8.37 -0.31 3.7e-16 D-dimer levels; BRCA cis rs6534441 0.697 rs56194872 chr4:125418343 G/T cg21609808 chr4:125404261 NA 0.36 7.89 0.3 1.28e-14 Major depressive disorder; BRCA cis rs6968419 0.747 rs1004109 chr7:115862296 A/T cg02561103 chr7:115862891 TES 0.35 7.83 0.3 2.08e-14 Intraocular pressure; BRCA cis rs4727027 0.899 rs11771339 chr7:148854132 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.1 0.4 2.64e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs12439619 0.921 rs56042848 chr15:82527585 A/T cg04831495 chr15:85060580 GOLGA6L5 -0.46 -11.2 -0.41 9.98e-27 Intelligence (multi-trait analysis); BRCA cis rs10189230 0.546 rs6727259 chr2:222358292 C/G cg14652038 chr2:222343519 EPHA4 -0.37 -9.06 -0.34 1.57e-18 Urate levels in lean individuals; BRCA cis rs10504229 0.683 rs16921937 chr8:58145010 A/G cg20607798 chr8:58055168 NA 0.46 8.09 0.3 2.92e-15 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.500 rs12371415 chr12:34521362 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.56 0.55 1.58e-51 Morning vs. evening chronotype; BRCA cis rs6912958 0.703 rs9353483 chr6:88097180 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.58 12.05 0.43 2.86e-30 Monocyte percentage of white cells; BRCA cis rs6484504 0.576 rs158144 chr11:31211795 A/C cg14844989 chr11:31128820 NA -0.44 -9.48 -0.35 5.02e-20 Red blood cell count; BRCA cis rs8141529 0.748 rs7287918 chr22:29281710 G/A cg02153584 chr22:29168773 CCDC117 0.52 10.84 0.39 2.94e-25 Lymphocyte counts; BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -8.97 -0.33 3.21e-18 Alzheimer's disease; BRCA cis rs10492096 0.947 rs11559082 chr12:6602367 C/T cg13857086 chr12:6580257 VAMP1 0.44 8.49 0.32 1.4e-16 Hip geometry; BRCA trans rs6933660 0.676 rs3757316 chr6:151774339 A/G cg12806826 chr1:1091669 NA 0.32 8.13 0.31 2.27e-15 Menarche (age at onset); BRCA cis rs2762353 0.718 rs1165160 chr6:25864456 A/G cg03517284 chr6:25882590 NA -0.52 -12.02 -0.43 3.78e-30 Blood metabolite levels; BRCA cis rs739401 0.572 rs12276060 chr11:3015572 A/T cg25174290 chr11:3078921 CARS 0.41 12.05 0.43 2.88e-30 Longevity; BRCA cis rs6694270 0.913 rs3935030 chr1:19116956 C/T cg26220594 chr1:19110978 NA -0.47 -8.79 -0.33 1.36e-17 Drug-induced liver injury (nitrofurantoin); BRCA cis rs10254118 0.730 rs6961517 chr7:133130940 G/T cg10665199 chr7:133106180 EXOC4 0.45 9.69 0.36 8.15e-21 Intelligence (multi-trait analysis); BRCA cis rs6964587 1.000 rs12533199 chr7:91757393 C/T cg17063962 chr7:91808500 NA 0.55 12.92 0.46 4.16e-34 Breast cancer; BRCA trans rs1005277 0.540 rs116205409 chr10:38478970 G/A cg17830980 chr10:43048298 ZNF37B -0.56 -13.68 -0.48 1.51e-37 Extrinsic epigenetic age acceleration; BRCA cis rs4409675 0.576 rs12062621 chr1:28230404 A/G cg23691781 chr1:28212827 C1orf38 0.32 10.64 0.39 1.86e-24 Corneal astigmatism; BRCA cis rs3806843 0.706 rs2563302 chr5:140079051 T/C cg11822812 chr5:140052017 DND1 -0.3 -8.23 -0.31 1.03e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs10089 1.000 rs4835945 chr5:127526481 C/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.55 12.54 0.44 2.17e-32 Ileal carcinoids; BRCA cis rs6121246 0.954 rs6060978 chr20:30416893 G/A cg21427119 chr20:30132790 HM13 -0.41 -8.72 -0.33 2.4e-17 Mean corpuscular hemoglobin; BRCA cis rs9814567 0.896 rs4245907 chr3:134347876 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -17.83 -0.58 5.39e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg24829409 chr8:58192753 C8orf71 0.54 9.39 0.35 1.07e-19 Developmental language disorder (linguistic errors); BRCA cis rs9467160 0.559 rs2753911 chr6:24442288 C/T cg20631270 chr6:24437470 GPLD1 0.55 11.53 0.41 4.63e-28 Liver enzyme levels; BRCA cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 8.48 0.32 1.52e-16 Platelet count; BRCA cis rs7772486 0.558 rs9376965 chr6:146130055 G/A cg05347473 chr6:146136440 FBXO30 0.62 12.15 0.43 1.07e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs2066819 1.000 rs116849218 chr12:56683975 C/T cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs1949733 0.701 rs940136 chr4:8448992 G/A cg13073564 chr4:8508604 NA -0.4 -10.68 -0.39 1.31e-24 Response to antineoplastic agents; BRCA cis rs2777491 0.872 rs7163649 chr15:41586798 A/G cg18705301 chr15:41695430 NDUFAF1 -0.6 -13.78 -0.48 5.01e-38 Ulcerative colitis; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg04013093 chr6:42928303 GNMT -0.28 -8.73 -0.33 2.16e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6964587 0.967 rs1978061 chr7:91779242 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.11 0.31 2.58e-15 Breast cancer; BRCA cis rs9807989 0.507 rs6743516 chr2:103036335 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.35 0.31 4.32e-16 Asthma; BRCA cis rs2191566 0.761 rs446016 chr19:44501518 A/G cg20607764 chr19:44506953 ZNF230 -0.45 -9.39 -0.35 1.02e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs9790314 0.581 rs6772578 chr3:160760851 T/A cg03342759 chr3:160939853 NMD3 -0.49 -9.31 -0.35 2e-19 Morning vs. evening chronotype; BRCA cis rs3768617 0.811 rs6674729 chr1:183059143 C/T ch.1.3577855R chr1:183094577 LAMC1 0.46 10.24 0.38 6.77e-23 Fuchs's corneal dystrophy; BRCA cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.5 -0.32 1.37e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs4727027 0.870 rs11525060 chr7:148801091 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.48 0.32 1.51e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6912958 0.514 rs7767449 chr6:87887985 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.6 -12.65 -0.45 6.73e-33 Monocyte percentage of white cells; BRCA cis rs1712517 0.566 rs7917388 chr10:105054963 C/T cg04362960 chr10:104952993 NT5C2 -0.39 -7.84 -0.3 1.94e-14 Migraine; BRCA cis rs10267417 0.603 rs34087364 chr7:19860293 A/C cg07541023 chr7:19748670 TWISTNB 0.5 8.98 0.33 2.91e-18 Night sleep phenotypes; BRCA trans rs3857536 0.813 rs7757647 chr6:66947207 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs7493 0.851 rs11770903 chr7:95026327 A/G cg19678392 chr7:94953810 PON1 -0.4 -8.13 -0.31 2.27e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7659604 0.539 rs11098646 chr4:122729301 T/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.39 -0.44 9.24e-32 Type 2 diabetes; BRCA cis rs10924970 0.967 rs8179454 chr1:235460719 C/G cg26050004 chr1:235667680 B3GALNT2 0.34 8.32 0.31 5.46e-16 Asthma; BRCA cis rs2153535 0.580 rs1928184 chr6:8532108 T/A cg21535247 chr6:8435926 SLC35B3 0.39 8.64 0.32 4.39e-17 Motion sickness; BRCA cis rs4689388 0.889 rs13101355 chr4:6293446 T/C cg25554036 chr4:6271136 WFS1 0.42 9.98 0.37 6.91e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7631605 0.905 rs7651903 chr3:37006686 T/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.8 0.36 3.08e-21 Cerebrospinal P-tau181p levels; BRCA trans rs3749237 0.964 rs34522271 chr3:49808517 A/G cg21659725 chr3:3221576 CRBN 0.5 11.82 0.42 2.71e-29 Resting heart rate; BRCA cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.37 0.35 1.21e-19 Tonsillectomy; BRCA cis rs2180341 0.695 rs6569487 chr6:127726196 C/T cg24812749 chr6:127587940 RNF146 -0.52 -11.64 -0.42 1.5e-28 Breast cancer; BRCA cis rs9811920 0.609 rs9817005 chr3:99682692 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.72 -0.55 2.49e-52 Axial length; BRCA cis rs9394152 0.845 rs4713632 chr6:33472990 G/T cg13560919 chr6:33536144 NA 0.62 12.76 0.45 2.26e-33 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs34779708 0.702 rs4007272 chr10:35546859 T/G cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1801251 0.778 rs709933 chr2:233733144 G/A cg25237894 chr2:233734115 C2orf82 -0.44 -14.22 -0.49 4.61e-40 Coronary artery disease; BRCA cis rs67981189 0.613 rs4366661 chr14:71452316 A/T cg15816911 chr14:71606274 NA -0.37 -8.39 -0.32 3.1e-16 Schizophrenia; BRCA cis rs13095912 1.000 rs4686666 chr3:185342847 T/C cg11274856 chr3:185301563 NA 0.34 8.37 0.31 3.72e-16 Systolic blood pressure; BRCA cis rs1577917 0.958 rs12192033 chr6:86472559 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -8.14 -0.31 2.1e-15 Response to antipsychotic treatment; BRCA cis rs10181042 0.565 rs2564117 chr2:61233022 A/T cg15711740 chr2:61764176 XPO1 -0.35 -8.26 -0.31 8.15e-16 Crohn's disease; BRCA cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg03644281 chr6:41068752 NFYA;LOC221442 0.42 9.04 0.34 1.81e-18 Alzheimer's disease (late onset); BRCA cis rs1018836 0.892 rs7819519 chr8:91565504 C/T cg16814680 chr8:91681699 NA -0.57 -12.34 -0.44 1.63e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs4481887 0.927 rs4244184 chr1:248486895 G/T cg00666640 chr1:248458726 OR2T12 0.32 8.94 0.33 4.09e-18 Common traits (Other); BRCA cis rs8031584 0.958 rs8034856 chr15:31240957 T/C cg08109568 chr15:31115862 NA -0.44 -10.39 -0.38 1.77e-23 Huntington's disease progression; BRCA cis rs1580019 0.587 rs6951955 chr7:32548761 A/T cg06627557 chr7:32535165 LSM5;AVL9 1.06 30.03 0.77 3.03e-124 Cognitive ability; BRCA cis rs9309473 0.718 rs6546829 chr2:73613789 C/G cg20560298 chr2:73613845 ALMS1 -0.51 -14.11 -0.49 1.58e-39 Metabolite levels; BRCA cis rs3741404 0.560 rs7938819 chr11:63910116 G/A cg18225595 chr11:63971243 STIP1 -0.41 -10.45 -0.38 1.08e-23 Platelet count; BRCA cis rs812925 0.512 rs1729674 chr2:61389737 T/G cg15711740 chr2:61764176 XPO1 -0.32 -7.98 -0.3 6.89e-15 Immature fraction of reticulocytes; BRCA cis rs9682041 0.800 rs7643085 chr3:170070371 A/G cg11886554 chr3:170076028 SKIL 0.69 12.87 0.45 7.58e-34 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs736408 0.527 rs2577831 chr3:52628056 C/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 8.56 0.32 8.52e-17 Bipolar disorder; BRCA cis rs765787 0.530 rs12905246 chr15:45500841 C/T cg25801113 chr15:45476975 SHF -0.33 -8.1 -0.31 2.78e-15 Uric acid levels; BRCA cis rs6120849 0.663 rs13041792 chr20:33545055 G/A cg24642439 chr20:33292090 TP53INP2 0.6 10.29 0.38 4.52e-23 Protein C levels; BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg00149659 chr3:10157352 C3orf10 1.1 18.73 0.6 1.05e-62 Alzheimer's disease; BRCA cis rs7737355 0.947 rs31254 chr5:130829404 C/T cg06307176 chr5:131281290 NA 0.52 10.46 0.38 9.23e-24 Life satisfaction; BRCA cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg26597838 chr10:835615 NA 1.0 15.64 0.53 6.72e-47 Eosinophil percentage of granulocytes; BRCA cis rs35110281 1.000 rs35110281 chr21:45068947 T/A cg04455712 chr21:45112962 RRP1B 0.39 9.98 0.37 6.59e-22 Mean corpuscular volume; BRCA trans rs12310956 0.532 rs1589903 chr12:33943019 C/T cg26384229 chr12:38710491 ALG10B 0.67 14.11 0.49 1.43e-39 Morning vs. evening chronotype; BRCA cis rs651907 0.557 rs7651404 chr3:101393294 C/A cg12386194 chr3:101231763 SENP7 0.45 9.53 0.35 3.27e-20 Colorectal cancer; BRCA cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg27535305 chr1:53392650 SCP2 0.32 8.07 0.3 3.46e-15 Monocyte count; BRCA cis rs7666738 0.830 rs11938686 chr4:98964470 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.17e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg12000995 chr2:27665139 KRTCAP3 -0.32 -8.04 -0.3 4.53e-15 Total body bone mineral density; BRCA cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg12373951 chr3:133503437 NA 0.46 10.75 0.39 6.63e-25 Iron status biomarkers; BRCA trans rs11098499 0.909 rs28571712 chr4:120375980 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.25 0.44 3.83e-31 Corneal astigmatism; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.43 -0.32 2.27e-16 Menopause (age at onset); BRCA cis rs2197308 0.623 rs1672426 chr12:38118671 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.07 -0.37 3.2e-22 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs6050632 chr20:25432601 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.5e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6963495 0.818 rs73190156 chr7:105153567 C/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1e-19 Bipolar disorder (body mass index interaction); BRCA cis rs6541297 1.000 rs1997947 chr1:230283764 A/G cg20703242 chr1:230279135 GALNT2 -0.47 -10.5 -0.38 6.86e-24 Coronary artery disease; BRCA trans rs61931739 0.500 rs10844863 chr12:34532284 C/T cg26384229 chr12:38710491 ALG10B 0.59 13.52 0.47 8.1e-37 Morning vs. evening chronotype; BRCA cis rs1371614 0.552 rs35538505 chr2:27126027 G/T cg00617064 chr2:27272375 NA 0.31 7.83 0.3 1.97e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs6088580 0.601 rs6059872 chr20:33082775 C/A cg24642439 chr20:33292090 TP53INP2 0.54 11.64 0.42 1.48e-28 Glomerular filtration rate (creatinine); BRCA cis rs13136331 0.684 rs1903798 chr4:88720018 A/G cg22416721 chr4:88570574 DMP1 0.39 8.39 0.32 3.09e-16 Sitting height ratio; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg07308232 chr7:1071921 C7orf50 -0.41 -8.39 -0.32 3.07e-16 Longevity;Endometriosis; BRCA cis rs1215050 0.791 rs592053 chr4:98732220 C/T cg05340658 chr4:99064831 C4orf37 0.45 10.41 0.38 1.45e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs798554 0.660 rs2527692 chr7:2856533 G/A cg19717773 chr7:2847554 GNA12 -0.43 -9.62 -0.36 1.5e-20 Height; BRCA cis rs7772486 0.558 rs702322 chr6:146007166 G/A cg23711669 chr6:146136114 FBXO30 -0.72 -14.66 -0.5 3.73e-42 Lobe attachment (rater-scored or self-reported); BRCA trans rs561341 1.000 rs2344312 chr17:30243583 G/T cg20587970 chr11:113659929 NA -0.83 -15.85 -0.53 6.11e-48 Hip circumference adjusted for BMI; BRCA cis rs7944584 0.610 rs2596407 chr11:47361838 A/G cg20307385 chr11:47447363 PSMC3 -0.5 -11.11 -0.4 2.46e-26 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10504229 0.683 rs79262965 chr8:58129826 G/T cg20607798 chr8:58055168 NA 0.58 9.19 0.34 5.3e-19 Developmental language disorder (linguistic errors); BRCA cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg10802521 chr3:52805072 NEK4 -0.31 -8.19 -0.31 1.44e-15 Bipolar disorder; BRCA cis rs9868809 0.505 rs35064573 chr3:48740280 C/A cg01304814 chr3:48885189 PRKAR2A 0.57 7.96 0.3 7.88e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs8180040 0.681 rs9818382 chr3:47193034 C/T cg27129171 chr3:47204927 SETD2 0.72 17.52 0.57 2.13e-56 Colorectal cancer; BRCA cis rs11105298 0.786 rs10777186 chr12:89921277 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.6 -0.36 1.76e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2243480 1.000 rs422164 chr7:65586605 C/G cg18252515 chr7:66147081 NA -1.06 -15.55 -0.52 1.79e-46 Diabetic kidney disease; BRCA cis rs28830936 1.000 rs12440747 chr15:42036690 G/A cg17847044 chr15:42102381 MAPKBP1 -0.37 -11.36 -0.41 2.25e-27 Diastolic blood pressure; BRCA cis rs1538970 0.781 rs713358 chr1:45988267 C/G cg05343316 chr1:45956843 TESK2 0.7 14.3 0.49 1.84e-40 Platelet count; BRCA cis rs10256972 0.552 rs2949192 chr7:1203841 C/T cg15112475 chr7:1198522 ZFAND2A -0.55 -13.43 -0.47 2.13e-36 Longevity;Endometriosis; BRCA cis rs6920965 0.507 rs9401853 chr6:126215197 A/T cg05901451 chr6:126070800 HEY2 -0.42 -10.34 -0.38 2.74e-23 High light scatter reticulocyte count; BRCA cis rs1707322 0.752 rs28890893 chr1:46186576 T/G cg06784218 chr1:46089804 CCDC17 0.5 12.03 0.43 3.45e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9814567 1.000 rs9829092 chr3:134229866 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.44 -0.32 2.09e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1552244 0.572 rs67227131 chr3:10172744 G/A cg00166722 chr3:10149974 C3orf24 0.61 8.83 0.33 9.7e-18 Alzheimer's disease; BRCA cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg08859206 chr1:53392774 SCP2 0.4 8.26 0.31 8.35e-16 Monocyte count; BRCA cis rs4820294 1.000 rs78974622 chr22:38059925 A/C cg21798802 chr22:38057573 PDXP 0.49 13.2 0.46 2.34e-35 Fat distribution (HIV); BRCA cis rs6456156 0.603 rs2345754 chr6:167484361 T/C cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs13064411 0.696 rs11921931 chr3:113015091 G/A cg18753928 chr3:113234510 CCDC52 -0.44 -8.21 -0.31 1.21e-15 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.67 -0.32 3.43e-17 Total body bone mineral density; BRCA cis rs8038465 0.622 rs2509 chr15:73859488 A/T cg15420318 chr15:73925796 NPTN -0.43 -9.3 -0.35 2.26e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs911555 0.755 rs12436729 chr14:103929889 G/C cg12935359 chr14:103987150 CKB 0.64 14.67 0.5 3.48e-42 Intelligence (multi-trait analysis); BRCA cis rs10789491 0.767 rs4660359 chr1:47190019 C/G cg15501359 chr1:47185051 KIAA0494 0.64 15.75 0.53 1.81e-47 Response to hepatitis C treatment; BRCA cis rs9393777 0.546 rs35589403 chr6:27219491 C/G cg12292205 chr6:26970375 C6orf41 -0.62 -10.03 -0.37 4.3e-22 Intelligence (multi-trait analysis); BRCA cis rs9837602 0.938 rs1021341 chr3:99786289 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.5 9.81 0.36 2.89e-21 Breast cancer; BRCA cis rs6964587 1.000 rs7806184 chr7:91601978 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.88e-15 Breast cancer; BRCA cis rs763121 0.853 rs5750672 chr22:39104168 C/T cg06022373 chr22:39101656 GTPBP1 -0.75 -18.9 -0.6 1.3e-63 Menopause (age at onset); BRCA cis rs1023500 0.596 rs133369 chr22:42463814 C/T cg15557168 chr22:42548783 NA -0.33 -8.5 -0.32 1.35e-16 Schizophrenia; BRCA cis rs73086581 1.000 rs11906274 chr20:3945536 G/A cg02187196 chr20:3869020 PANK2 0.51 9.28 0.34 2.51e-19 Response to antidepressants in depression; BRCA cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg13114125 chr14:105738426 BRF1 -0.53 -11.07 -0.4 3.42e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06544989 chr22:39130855 UNC84B 0.41 9.33 0.35 1.75e-19 Menopause (age at onset); BRCA cis rs523522 0.923 rs2235217 chr12:120884328 C/T cg27279351 chr12:120934652 DYNLL1 0.56 13.01 0.46 1.74e-34 High light scatter reticulocyte count; BRCA cis rs736408 0.609 rs13061423 chr3:52790213 T/C cg10802521 chr3:52805072 NEK4 -0.31 -8.07 -0.3 3.44e-15 Bipolar disorder; BRCA cis rs2019216 1.000 rs2019216 chr17:21909650 C/T cg22648282 chr17:21454238 C17orf51 -0.36 -8.19 -0.31 1.47e-15 Pelvic organ prolapse; BRCA cis rs4819052 0.724 rs9753962 chr21:46661384 G/T cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13191362 0.810 rs13200053 chr6:163011443 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.91 0.45 4.89e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg11764359 chr7:65958608 NA -0.77 -17.87 -0.58 3.29e-58 Aortic root size; BRCA cis rs12477438 0.798 rs13409996 chr2:99575497 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.64 -0.5 4.62e-42 Chronic sinus infection; BRCA trans rs11098499 0.955 rs13114751 chr4:120156617 G/A cg25214090 chr10:38739885 LOC399744 0.51 10.99 0.4 7.33e-26 Corneal astigmatism; BRCA cis rs9325144 0.671 rs35817541 chr12:38975001 T/C cg26384229 chr12:38710491 ALG10B -0.48 -11.49 -0.41 6.5e-28 Morning vs. evening chronotype; BRCA cis rs7586879 0.765 rs11683429 chr2:25120733 T/A cg04586622 chr2:25135609 ADCY3 0.4 9.59 0.35 1.93e-20 Body mass index; BRCA cis rs7666738 0.830 rs10000573 chr4:99048785 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12618769 0.597 rs1847550 chr2:99052299 C/T cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.71e-15 Bipolar disorder; BRCA cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg24578937 chr1:2090814 PRKCZ -0.34 -10.18 -0.37 1.22e-22 Height; BRCA cis rs4949454 0.542 rs10914457 chr1:32094261 A/C cg11573219 chr1:32083031 HCRTR1 -0.27 -8.09 -0.3 3e-15 Intelligence (multi-trait analysis); BRCA cis rs701145 0.585 rs6789213 chr3:153792795 T/C cg17054900 chr3:154042577 DHX36 0.54 9.15 0.34 7.49e-19 Coronary artery disease; BRCA cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg24642439 chr20:33292090 TP53INP2 -0.43 -8.7 -0.33 2.89e-17 Height; BRCA cis rs4319547 0.737 rs4758646 chr12:122946507 G/A cg05707623 chr12:122985044 ZCCHC8 -0.39 -8.33 -0.31 4.88e-16 Body mass index; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg16145915 chr7:1198662 ZFAND2A -0.67 -18.07 -0.58 3e-59 Longevity;Endometriosis; BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg12311346 chr5:56204834 C5orf35 -0.78 -16.19 -0.54 1.22e-49 Initial pursuit acceleration; BRCA cis rs6460942 0.687 rs74753576 chr7:12463926 G/A cg20607287 chr7:12443886 VWDE -0.53 -8.23 -0.31 1.03e-15 Coronary artery disease; BRCA cis rs17685 0.671 rs10274404 chr7:75706634 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.76 -0.33 1.74e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7613875 0.641 rs6446194 chr3:50067298 T/A cg24110177 chr3:50126178 RBM5 0.53 15.89 0.53 3.76e-48 Body mass index; BRCA cis rs2075371 0.796 rs12672752 chr7:134007382 C/T cg20476274 chr7:133979776 SLC35B4 0.59 15.46 0.52 4.63e-46 Mean platelet volume; BRCA cis rs6061231 0.793 rs2427320 chr20:60976723 A/G cg22633769 chr20:60982531 CABLES2 0.44 8.01 0.3 5.28e-15 Colorectal cancer; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg07691484 chr11:842764 TSPAN4;POLR2L -0.69 -16.21 -0.54 9.72e-50 Mean platelet volume; BRCA cis rs13191362 1.000 rs73035021 chr6:163000716 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg04267008 chr7:1944627 MAD1L1 -0.6 -13.11 -0.46 6.01e-35 Bipolar disorder and schizophrenia; BRCA trans rs61931739 0.929 rs1844524 chr12:34094709 A/T cg26384229 chr12:38710491 ALG10B -0.43 -10.31 -0.38 3.53e-23 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg21724239 chr8:58056113 NA 0.58 9.41 0.35 8.76e-20 Developmental language disorder (linguistic errors); BRCA cis rs2294693 0.945 rs9369253 chr6:40986538 A/G cg14418226 chr6:40996092 UNC5CL 0.45 8.0 0.3 6.06e-15 Gastric cancer;Non-cardia gastric cancer; BRCA trans rs12188164 0.610 rs6555242 chr5:416546 A/C cg15371732 chr17:78194151 SLC26A11;SGSH 0.37 9.1 0.34 1.14e-18 Cystic fibrosis severity; BRCA cis rs34375054 0.738 rs10773145 chr12:125625603 C/T cg25124228 chr12:125621409 AACS 0.5 11.46 0.41 9.13e-28 Post bronchodilator FEV1/FVC ratio; BRCA cis rs12493885 0.769 rs11710560 chr3:153777276 A/G cg17054900 chr3:154042577 DHX36 -0.5 -8.64 -0.32 4.44e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs10506458 0.915 rs12424908 chr12:63402364 G/A cg22491629 chr6:157744540 C6orf35 -0.67 -12.04 -0.43 3.02e-30 Hemostatic factors and hematological phenotypes; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.02 -17.94 -0.58 1.32e-58 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7613875 0.537 rs6446195 chr3:50070853 A/G cg05623727 chr3:50126028 RBM5 -0.49 -11.7 -0.42 8.58e-29 Body mass index; BRCA cis rs4363385 0.818 rs684305 chr1:153006242 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.28 -0.34 2.62e-19 Inflammatory skin disease; BRCA cis rs1552244 1.000 rs9834980 chr3:10065528 G/A cg08888203 chr3:10149979 C3orf24 0.61 13.03 0.46 1.34e-34 Alzheimer's disease; BRCA cis rs9807989 0.507 rs1592458 chr2:103031749 A/T cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma; BRCA cis rs55883249 1.000 rs62119429 chr2:9743585 G/C cg23886495 chr2:9695866 ADAM17 0.55 7.89 0.3 1.27e-14 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs6912958 0.712 rs4498321 chr6:88339251 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.62 -0.32 5.38e-17 Monocyte percentage of white cells; BRCA cis rs514406 0.929 rs1242224 chr1:53314887 G/A cg24675658 chr1:53192096 ZYG11B -0.51 -11.25 -0.41 6.58e-27 Monocyte count; BRCA cis rs1707322 1.000 rs4660328 chr1:46444831 G/T cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9467773 0.620 rs1027204 chr6:26639613 T/C cg11502198 chr6:26597334 ABT1 0.56 12.0 0.43 4.68e-30 Intelligence (multi-trait analysis); BRCA cis rs4074536 0.536 rs6687777 chr1:116289707 T/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs9816226 0.938 rs73052046 chr3:185832414 C/T cg00760338 chr3:185826511 ETV5 -0.53 -8.83 -0.33 1.03e-17 Obesity;Body mass index; BRCA cis rs769267 1.000 rs7246748 chr19:19433105 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.28 -0.44 2.95e-31 Tonsillectomy; BRCA cis rs4665809 1.000 rs7599132 chr2:26279810 A/T cg25036284 chr2:26402008 FAM59B 0.67 11.0 0.4 7.11e-26 Gut microbiome composition (summer); BRCA cis rs6545883 0.929 rs2121660 chr2:61653058 T/C cg15711740 chr2:61764176 XPO1 0.53 12.78 0.45 1.79e-33 Tuberculosis; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs2204008 0.537 rs28680519 chr12:38502946 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.79 0.36 3.51e-21 Bladder cancer; BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26314531 chr2:26401878 FAM59B -0.69 -11.53 -0.41 4.68e-28 Gut microbiome composition (summer); BRCA cis rs6840258 0.943 rs72667748 chr4:87927034 C/T cg08197287 chr4:87952173 AFF1 -0.44 -8.71 -0.33 2.67e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs4819052 0.851 rs2838856 chr21:46680766 T/G cg06618935 chr21:46677482 NA -0.35 -8.0 -0.3 5.93e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7474896 0.609 rs11011336 chr10:37985316 A/G cg25427524 chr10:38739819 LOC399744 -0.54 -9.95 -0.37 9.15e-22 Obesity (extreme); BRCA cis rs6088813 0.857 rs1886692 chr20:33986549 C/T cg14752227 chr20:34000481 UQCC -0.42 -8.83 -0.33 1.02e-17 Height; BRCA cis rs6433895 1.000 rs55900432 chr2:182017904 G/A cg00481216 chr2:181971175 NA 0.39 8.91 0.33 5.34e-18 Lymphocyte counts; BRCA cis rs9790314 1.000 rs9870059 chr3:161017240 T/C cg04691961 chr3:161091175 C3orf57 -0.59 -14.13 -0.49 1.26e-39 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs7696568 chr4:99005333 A/T cg03676636 chr4:99064102 C4orf37 0.2 7.92 0.3 1.03e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9733 0.519 rs2184833 chr1:150675483 C/T cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 3.95e-15 Tonsillectomy; BRCA cis rs10504229 0.683 rs7820302 chr8:58142502 C/T cg20607798 chr8:58055168 NA 0.46 8.27 0.31 7.96e-16 Developmental language disorder (linguistic errors); BRCA trans rs1493916 0.837 rs2123333 chr18:31410730 G/A cg27147174 chr7:100797783 AP1S1 -0.42 -8.52 -0.32 1.17e-16 Life satisfaction; BRCA cis rs9467773 0.901 rs1407045 chr6:26476155 A/G cg11502198 chr6:26597334 ABT1 0.44 8.22 0.31 1.17e-15 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.866 rs6824111 chr4:120285968 T/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs10504229 1.000 rs7007805 chr8:58179327 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg25036284 chr2:26402008 FAM59B 0.63 10.7 0.39 1.09e-24 Gut microbiome composition (summer); BRCA trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.22 0.54 8.5e-50 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.768 rs351742 chr6:109527325 C/T cg21918786 chr6:109611834 NA 0.34 9.16 0.34 7.03e-19 Reticulocyte fraction of red cells; BRCA cis rs1003719 0.715 rs762139 chr21:38568475 A/T cg10648535 chr21:38446584 PIGP;TTC3 0.51 12.03 0.43 3.34e-30 Eye color traits; BRCA cis rs2108225 0.900 rs7805114 chr7:107450033 G/T cg18560240 chr7:107437656 SLC26A3 0.53 11.31 0.41 3.66e-27 Ulcerative colitis; BRCA cis rs9311474 0.629 rs11709284 chr3:52559705 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.36 7.83 0.3 2.1e-14 Electroencephalogram traits; BRCA cis rs2239547 0.522 rs6770957 chr3:52995416 T/C cg11645453 chr3:52864694 ITIH4 0.44 10.65 0.39 1.73e-24 Schizophrenia; BRCA cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.95 -0.4 1.12e-25 Personality dimensions; BRCA cis rs7586673 0.930 rs2884364 chr2:161977647 G/A cg08807892 chr2:162101083 NA 0.51 10.1 0.37 2.35e-22 Intelligence (multi-trait analysis); BRCA cis rs9487051 0.698 rs9374081 chr6:109631782 A/G cg21918786 chr6:109611834 NA -0.36 -8.34 -0.31 4.74e-16 Reticulocyte fraction of red cells; BRCA cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.87 13.61 0.47 3.3e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12950390 0.853 rs55745341 chr17:45855778 G/C cg24803719 chr17:45855879 NA -0.33 -8.71 -0.33 2.57e-17 IgG glycosylation; BRCA cis rs9329289 0.632 rs2452187 chr10:2551147 C/G cg15501526 chr10:2543763 NA 0.55 12.54 0.44 2.18e-32 Age-related hearing impairment; BRCA cis rs13118159 0.550 rs13123016 chr4:1340889 T/C cg16405210 chr4:1374714 KIAA1530 -0.91 -19.55 -0.61 4.62e-67 Longevity; BRCA cis rs2066819 1.000 rs78121408 chr12:56684798 C/T cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA trans rs10506458 0.834 rs12426893 chr12:63388120 G/T cg22491629 chr6:157744540 C6orf35 -0.65 -11.66 -0.42 1.31e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs7512552 0.839 rs832622 chr1:150392830 A/G cg15654264 chr1:150340011 RPRD2 0.37 8.16 0.31 1.76e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs2276314 0.762 rs3826600 chr18:33609053 A/G cg05985134 chr18:33552581 C18orf21 0.65 12.29 0.44 2.63e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs694739 0.628 rs538147 chr11:64129722 G/A cg26898376 chr11:64110657 CCDC88B 0.36 7.96 0.3 8.02e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA trans rs3780486 0.846 rs7036812 chr9:33143822 T/C cg20290983 chr6:43655470 MRPS18A 1.1 38.39 0.84 4.28e-168 IgG glycosylation; BRCA cis rs7523273 0.927 rs2796275 chr1:207950490 C/T cg22525895 chr1:207977042 MIR29B2 0.47 11.3 0.41 3.88e-27 Schizophrenia; BRCA cis rs6665290 0.901 rs61834004 chr1:227202782 G/A cg10327440 chr1:227177885 CDC42BPA -1.14 -44.45 -0.87 1.14e-197 Myeloid white cell count; BRCA trans rs1422110 0.616 rs6452688 chr5:85445038 C/T cg01787110 chr1:109008453 NBPF6 0.41 8.7 0.33 2.9e-17 Attention function in attention deficit hyperactive disorder; BRCA cis rs2688608 0.592 rs10762560 chr10:75495405 T/G cg23231163 chr10:75533350 FUT11 -0.33 -8.78 -0.33 1.47e-17 Inflammatory bowel disease; BRCA cis rs10504229 0.683 rs61241336 chr8:58106585 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.05 -0.34 1.71e-18 Developmental language disorder (linguistic errors); BRCA cis rs9467711 0.591 rs13216785 chr6:26079185 C/T cg08501292 chr6:25962987 TRIM38 0.57 8.02 0.3 5.07e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs16958440 0.581 rs11082564 chr18:44659149 C/G cg17192377 chr18:44677553 HDHD2 0.49 8.3 0.31 6.37e-16 Sitting height ratio; BRCA trans rs7395662 0.504 rs11039701 chr11:48389838 A/G cg00717180 chr2:96193071 NA -0.37 -10.28 -0.38 4.74e-23 HDL cholesterol; BRCA cis rs72781680 0.821 rs12623521 chr2:24181670 C/T cg08917208 chr2:24149416 ATAD2B 0.62 10.39 0.38 1.76e-23 Lymphocyte counts; BRCA cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.59 12.35 0.44 1.49e-31 Age-related macular degeneration (geographic atrophy); BRCA cis rs8114671 0.836 rs62213676 chr20:33612676 T/A cg24642439 chr20:33292090 TP53INP2 -0.41 -8.41 -0.32 2.7e-16 Height; BRCA cis rs858239 1.000 rs166663 chr7:23316742 A/C cg23682824 chr7:23144976 KLHL7 0.35 8.83 0.33 9.73e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg26874164 chr19:58962979 ZNF324B 0.44 9.3 0.35 2.11e-19 Uric acid clearance; BRCA trans rs637571 0.522 rs503524 chr11:65751764 C/T cg17712092 chr4:129076599 LARP1B 0.56 13.53 0.47 7.72e-37 Eosinophil percentage of white cells; BRCA cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg18225595 chr11:63971243 STIP1 0.51 9.4 0.35 9.82e-20 Mean platelet volume; BRCA cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.78 -0.58 9.4e-58 Chronic sinus infection; BRCA trans rs57046232 0.552 rs2009127 chr20:6341680 C/T cg21095983 chr6:86352623 SYNCRIP 0.38 7.97 0.3 7.18e-15 Colorectal cancer; BRCA cis rs921968 0.508 rs72965103 chr2:219312469 T/C cg10223061 chr2:219282414 VIL1 0.29 8.47 0.32 1.66e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs7927771 0.524 rs7111576 chr11:47787445 G/A cg20307385 chr11:47447363 PSMC3 0.42 9.56 0.35 2.48e-20 Subjective well-being; BRCA cis rs1707322 0.686 rs1084086 chr1:46041100 A/C cg03146154 chr1:46216737 IPP -0.49 -10.78 -0.39 5.08e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4664304 0.620 rs12692568 chr2:160718440 T/C cg01092293 chr2:160761427 LY75 0.35 8.41 0.32 2.66e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.68e-43 Aortic root size; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg00166722 chr3:10149974 C3orf24 -0.68 -13.63 -0.47 2.47e-37 Alzheimer's disease; BRCA cis rs2180341 0.566 rs982306 chr6:127777039 T/C cg27446573 chr6:127587934 RNF146 0.6 12.9 0.45 5.33e-34 Breast cancer; BRCA cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.905 rs8189449 chr12:38437377 C/A cg13010199 chr12:38710504 ALG10B 0.4 8.34 0.31 4.52e-16 Bladder cancer; BRCA cis rs7618915 0.501 rs3733041 chr3:52731598 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.58e-29 Bipolar disorder; BRCA cis rs61931739 0.500 rs7137392 chr12:34447074 T/C cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.79e-23 Morning vs. evening chronotype; BRCA cis rs3733346 0.520 rs62297086 chr4:909040 G/A cg20916646 chr4:852691 GAK 0.44 10.33 0.38 3.14e-23 Sjögren's syndrome; BRCA cis rs1008375 1.000 rs1974624 chr4:17650281 A/G cg02297831 chr4:17616191 MED28 0.37 8.71 0.33 2.68e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7568458 0.663 rs699664 chr2:85780536 A/G cg02493740 chr2:85810744 VAMP5 0.63 14.32 0.49 1.57e-40 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs2880765 0.835 rs11638498 chr15:86023018 T/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.52 -0.32 1.14e-16 Coronary artery disease; BRCA cis rs939658 0.776 rs869672 chr15:79430860 G/A cg17916960 chr15:79447300 NA -0.46 -11.41 -0.41 1.45e-27 Refractive error; BRCA trans rs11098499 0.954 rs9685777 chr4:120365965 C/A cg25214090 chr10:38739885 LOC399744 0.56 12.92 0.46 4.23e-34 Corneal astigmatism; BRCA cis rs11098499 0.739 rs7441137 chr4:120133221 G/T cg09307838 chr4:120376055 NA -0.49 -9.27 -0.34 2.75e-19 Corneal astigmatism; BRCA cis rs10504229 0.953 rs6991035 chr8:58183374 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs9549260 0.755 rs9549236 chr13:41147158 C/T cg21288729 chr13:41239152 FOXO1 -0.64 -13.49 -0.47 1.16e-36 Red blood cell count; BRCA cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg04842962 chr6:43655489 MRPS18A 0.97 22.27 0.66 9.55e-82 IgG glycosylation; BRCA trans rs6582630 0.555 rs7978749 chr12:38527141 G/T cg06521331 chr12:34319734 NA -0.47 -8.7 -0.33 2.8e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs72781680 0.846 rs72780198 chr2:24014883 T/A cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs67478160 0.619 rs8018062 chr14:104281954 C/T cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.27 -0.41 5.49e-27 Schizophrenia; BRCA cis rs12586317 0.547 rs78609489 chr14:35497285 T/C cg16230307 chr14:35515116 FAM177A1 0.75 14.98 0.51 1.08e-43 Psoriasis; BRCA cis rs7799006 1.000 rs7810970 chr7:2276385 A/G cg08027265 chr7:2291960 NA -0.41 -10.51 -0.38 6.36e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.34 0.49 1.23e-40 Personality dimensions; BRCA cis rs1401999 0.510 rs17817736 chr3:183720313 A/T cg01324343 chr3:183735012 ABCC5 -0.43 -9.73 -0.36 5.9e-21 Anterior chamber depth; BRCA cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg22535103 chr8:58192502 C8orf71 -0.58 -12.6 -0.45 1.11e-32 Developmental language disorder (linguistic errors); BRCA cis rs9814567 1.000 rs2056603 chr3:134312749 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.4 -9.32 -0.35 1.88e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg00106254 chr7:1943704 MAD1L1 -0.38 -9.48 -0.35 5.07e-20 Bipolar disorder and schizophrenia; BRCA cis rs4665809 0.887 rs2384324 chr2:26354239 A/G cg08470875 chr2:26401718 FAM59B -0.63 -9.5 -0.35 3.99e-20 Gut microbiome composition (summer); BRCA cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.5 10.71 0.39 9.67e-25 Aortic root size; BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.93 -20.41 -0.63 1.2e-71 Gut microbiome composition (summer); BRCA cis rs2070488 1.000 rs34258593 chr3:38464565 T/C cg24069376 chr3:38537580 EXOG 0.41 11.79 0.42 3.67e-29 Electrocardiographic conduction measures; BRCA cis rs11098499 0.954 rs35091806 chr4:120325529 G/A cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs12493885 0.818 rs10935971 chr3:153773945 C/T cg17054900 chr3:154042577 DHX36 -0.5 -8.65 -0.32 4.07e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs243505 0.898 rs243532 chr7:148412371 A/G cg09806900 chr7:148480153 CUL1 -0.42 -8.46 -0.32 1.85e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6714710 0.603 rs1875699 chr2:98580724 G/T cg26665480 chr2:98280029 ACTR1B 0.57 13.43 0.47 2.09e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs11971779 0.680 rs3924296 chr7:139041927 T/C cg07862535 chr7:139043722 LUC7L2 0.38 10.37 0.38 2.13e-23 Diisocyanate-induced asthma; BRCA cis rs9322193 0.923 rs9766004 chr6:150075499 C/T cg04369109 chr6:150039330 LATS1 -0.39 -9.07 -0.34 1.49e-18 Lung cancer; BRCA cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg00825309 chr19:58991885 ZNF446 -0.58 -12.62 -0.45 8.95e-33 Uric acid clearance; BRCA cis rs7552404 0.731 rs5745491 chr1:76350159 T/G cg10523679 chr1:76189770 ACADM -0.62 -11.38 -0.41 1.97e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9486715 0.867 rs4839687 chr6:96951732 C/A cg06623918 chr6:96969491 KIAA0776 0.9 25.97 0.72 4.85e-102 Headache; BRCA cis rs6901250 0.807 rs1606366 chr6:117132438 C/G cg12892004 chr6:117198278 RFX6 0.49 11.44 0.41 1.03e-27 C-reactive protein levels; BRCA cis rs4713118 0.513 rs202908 chr6:28011551 C/G cg10876282 chr6:28092338 ZSCAN16 0.41 7.98 0.3 7.03e-15 Parkinson's disease; BRCA cis rs2153535 0.563 rs3117071 chr6:8537908 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.14 0.34 8.36e-19 Motion sickness; BRCA trans rs11098499 0.954 rs10005644 chr4:120298477 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs7246657 0.943 rs10406177 chr19:37907947 G/A cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA cis rs1552244 1.000 rs56394721 chr3:10150795 A/G cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 18.39 0.59 6.38e-61 Alzheimer's disease; BRCA cis rs60871478 0.947 rs4074610 chr7:791755 G/A cg04727924 chr7:799746 HEATR2 -0.55 -10.79 -0.39 4.91e-25 Cerebrospinal P-tau181p levels; BRCA cis rs10752881 1.000 rs6424880 chr1:182986679 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.17e-52 Colorectal cancer; BRCA cis rs847577 0.651 rs10464490 chr7:97715319 T/G cg21770322 chr7:97807741 LMTK2 0.58 16.92 0.56 2.4e-53 Breast cancer; BRCA cis rs367943 1.000 rs348948 chr5:112822452 A/C cg12552261 chr5:112820674 MCC -0.55 -12.09 -0.43 1.98e-30 Type 2 diabetes; BRCA cis rs6582630 0.519 rs11514078 chr12:38408817 G/C cg13010199 chr12:38710504 ALG10B 0.5 10.16 0.37 1.34e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs9291683 0.585 rs12648479 chr4:10104571 G/A cg00071950 chr4:10020882 SLC2A9 -0.5 -11.95 -0.43 7.86e-30 Bone mineral density; BRCA cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg04944784 chr2:26401820 FAM59B 0.6 9.75 0.36 4.87e-21 Gut microbiome composition (summer); BRCA cis rs1448094 0.512 rs12305828 chr12:86249153 C/G cg19622623 chr12:86230825 RASSF9 -0.33 -9.38 -0.35 1.14e-19 Major depressive disorder; BRCA trans rs61931739 0.534 rs7313137 chr12:34010231 T/G cg13010199 chr12:38710504 ALG10B 0.47 9.03 0.34 2.04e-18 Morning vs. evening chronotype; BRCA cis rs801193 0.742 rs9969300 chr7:65781646 G/A cg11764359 chr7:65958608 NA -0.5 -10.71 -0.39 1.03e-24 Aortic root size; BRCA cis rs7811142 0.943 rs11769886 chr7:99998607 G/A cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 19.95 0.62 3.47e-69 Platelet count; BRCA cis rs4363385 0.818 rs2070963 chr1:153004004 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.17 -0.34 6.35e-19 Inflammatory skin disease; BRCA cis rs7829975 0.624 rs7823056 chr8:8382705 A/G cg06636001 chr8:8085503 FLJ10661 0.65 15.22 0.52 7.18e-45 Mood instability; BRCA cis rs17376456 0.877 rs17083455 chr5:93446380 A/C cg09848695 chr5:92956644 FAM172A;MIR2277 0.59 8.12 0.31 2.39e-15 Diabetic retinopathy; BRCA cis rs2742234 0.541 rs10899786 chr10:43744583 G/A cg15436174 chr10:43711423 RASGEF1A 0.52 10.11 0.37 2.2e-22 Hirschsprung disease; BRCA cis rs1790761 0.501 rs4930210 chr11:67404726 G/T cg14500267 chr11:67383377 NA -0.42 -9.34 -0.35 1.59e-19 Mean corpuscular volume; BRCA cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg06064525 chr11:970664 AP2A2 -0.48 -15.95 -0.53 1.8e-48 Alzheimer's disease (late onset); BRCA cis rs13191362 0.935 rs116735807 chr6:163010615 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.05 0.34 1.7e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.546 rs10010088 chr4:98655945 C/T cg05340658 chr4:99064831 C4orf37 0.57 10.94 0.4 1.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg27478167 chr7:817139 HEATR2 -0.42 -9.01 -0.34 2.28e-18 Cerebrospinal P-tau181p levels; BRCA cis rs7646881 1.000 rs59313096 chr3:158452242 G/C cg19483011 chr3:158453295 NA -0.5 -9.37 -0.35 1.22e-19 Tetralogy of Fallot; BRCA cis rs9325144 0.678 rs7315271 chr12:39164731 A/G cg26384229 chr12:38710491 ALG10B -0.5 -11.07 -0.4 3.61e-26 Morning vs. evening chronotype; BRCA cis rs3858526 0.584 rs10769274 chr11:5866925 T/C cg13902645 chr11:5959945 NA -0.48 -10.18 -0.37 1.21e-22 DNA methylation (variation); BRCA trans rs11098499 0.863 rs6853998 chr4:120475860 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg13944838 chr5:179740914 GFPT2 -0.71 -15.06 -0.51 4.28e-44 Height; BRCA cis rs910316 0.935 rs175076 chr14:75505486 A/G cg08847533 chr14:75593920 NEK9 -0.85 -21.47 -0.65 2.24e-77 Height; BRCA trans rs561341 1.000 rs473356 chr17:30321762 G/C cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.26e-27 Hip circumference adjusted for BMI; BRCA trans rs10411161 0.702 rs11878580 chr19:52388485 C/T cg22319618 chr22:45562946 NUP50 -0.42 -8.02 -0.3 4.89e-15 Breast cancer; BRCA cis rs2303745 0.589 rs1864115 chr19:17393327 G/C cg10664184 chr19:17420304 DDA1 0.36 10.24 0.38 6.85e-23 Systemic lupus erythematosus; BRCA cis rs4975616 0.714 rs27069 chr5:1347128 C/T cg26373071 chr5:1325741 CLPTM1L 0.42 9.9 0.36 1.35e-21 Lung cancer; BRCA cis rs11874712 0.932 rs8092674 chr18:43665982 C/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs765787 0.530 rs1706832 chr15:45517173 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.35 -0.41 2.48e-27 Uric acid levels; BRCA cis rs752010 0.631 rs4660549 chr1:42088102 A/G cg06885757 chr1:42089581 HIVEP3 0.42 13.52 0.47 8.16e-37 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs10504229 0.683 rs73605816 chr8:58117167 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs12545109 0.800 rs2221919 chr8:57412541 A/C cg09654669 chr8:57350985 NA -0.38 -8.34 -0.31 4.55e-16 Obesity-related traits; BRCA cis rs9443645 0.901 rs9352670 chr6:79584433 A/G cg11833968 chr6:79620685 NA -0.43 -9.7 -0.36 7.32e-21 Intelligence (multi-trait analysis); BRCA cis rs483180 0.512 rs594400 chr1:120214275 G/T cg19096424 chr1:120255104 PHGDH -0.43 -9.61 -0.36 1.66e-20 Macular telangiectasia type 2; BRCA cis rs10504229 0.595 rs79077737 chr8:58117520 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.93 -0.33 4.35e-18 Developmental language disorder (linguistic errors); BRCA trans rs3857536 0.740 rs9354391 chr6:66890183 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.46 9.37 0.35 1.21e-19 Blood trace element (Cu levels); BRCA cis rs706334 0.905 rs706333 chr4:140517700 A/G cg22540532 chr4:140518177 NA -0.46 -10.33 -0.38 3.03e-23 LDL peak particle diameter (total fat intake interaction); BRCA cis rs7254114 0.618 rs7250652 chr19:11302606 A/G cg02815516 chr19:11306319 KANK2 -0.34 -9.97 -0.37 7.49e-22 Immature fraction of reticulocytes; BRCA cis rs6952808 1.000 rs4256490 chr7:1890764 G/A cg00106254 chr7:1943704 MAD1L1 -0.41 -10.02 -0.37 4.7e-22 Bipolar disorder and schizophrenia; BRCA cis rs9467773 0.596 rs2451751 chr6:26646714 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.29e-42 Intelligence (multi-trait analysis); BRCA cis rs3796352 1.000 rs71617204 chr3:53042951 G/A cg07884673 chr3:53033167 SFMBT1 0.87 10.25 0.38 6.37e-23 Immune reponse to smallpox (secreted IL-2); BRCA cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.27 9.01 0.34 2.35e-18 Systemic lupus erythematosus; BRCA cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg21475434 chr5:93447410 FAM172A 0.68 8.9 0.33 5.7e-18 Diabetic retinopathy; BRCA trans rs9291683 0.551 rs2276961 chr4:10022981 C/T cg26043149 chr18:55253948 FECH 0.4 8.53 0.32 1.07e-16 Bone mineral density; BRCA cis rs10267417 0.657 rs12668709 chr7:19858946 T/G cg05791153 chr7:19748676 TWISTNB 0.52 9.83 0.36 2.55e-21 Night sleep phenotypes; BRCA cis rs2019216 0.542 rs3829569 chr17:21909222 T/C cg22648282 chr17:21454238 C17orf51 -0.41 -9.44 -0.35 6.98e-20 Pelvic organ prolapse; BRCA cis rs10504229 1.000 rs111915672 chr8:58191665 T/C cg14926445 chr8:58193284 C8orf71 -0.47 -8.93 -0.33 4.61e-18 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.825 rs1000464 chr7:65777909 G/C cg11764359 chr7:65958608 NA -0.77 -17.56 -0.57 1.3e-56 Aortic root size; BRCA cis rs6570726 0.875 rs1883407 chr6:145823432 T/C cg23711669 chr6:146136114 FBXO30 0.64 15.0 0.51 8.96e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs3806843 0.735 rs2563335 chr5:140044292 A/C cg26395211 chr5:140044315 WDR55 -0.37 -8.41 -0.32 2.61e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs7618915 0.547 rs2289250 chr3:52682946 A/C cg11041457 chr3:52719354 GNL3;PBRM1 -0.34 -10.78 -0.39 5.2e-25 Bipolar disorder; BRCA cis rs7264396 1.000 rs224435 chr20:34154087 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.44 -9.39 -0.35 1e-19 Total cholesterol levels; BRCA cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg18132916 chr6:79620363 NA -0.47 -10.66 -0.39 1.6e-24 Intelligence (multi-trait analysis); BRCA cis rs2505998 0.833 rs2742244 chr10:43603592 G/C cg15436174 chr10:43711423 RASGEF1A -0.39 -7.98 -0.3 6.97e-15 Hirschsprung disease; BRCA cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg13010199 chr12:38710504 ALG10B 0.51 9.95 0.37 8.8e-22 Bladder cancer; BRCA cis rs10499694 0.933 rs998850 chr7:50607388 G/C cg18232548 chr7:50535776 DDC -0.39 -9.26 -0.34 2.95e-19 Body mass index; BRCA cis rs4988958 0.565 rs6760621 chr2:102999952 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.41 0.32 2.59e-16 Asthma (childhood onset); BRCA cis rs9462027 0.539 rs9469883 chr6:34758627 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.42e-14 Systemic lupus erythematosus; BRCA cis rs7833986 0.534 rs17814089 chr8:56965563 A/G cg23139584 chr8:56987506 RPS20;SNORD54 -0.71 -13.56 -0.47 5.67e-37 Height; BRCA cis rs832540 0.656 rs832567 chr5:56152416 C/A cg12311346 chr5:56204834 C5orf35 -0.48 -9.93 -0.37 1.04e-21 Coronary artery disease; BRCA cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.33 0.31 4.82e-16 Multiple sclerosis; BRCA cis rs7264396 0.690 rs2425172 chr20:34443893 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.04 0.3 4.33e-15 Total cholesterol levels; BRCA cis rs66782572 1 rs66782572 chr3:52567617 A/G cg17372223 chr3:52568218 NT5DC2 0.38 9.21 0.34 4.7e-19 Hemoglobin concentration; BRCA trans rs35110281 0.811 rs7275705 chr21:45056453 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.25 0.38 6.12e-23 Mean corpuscular volume; BRCA cis rs9921222 0.632 rs11649268 chr16:398643 A/C cg08923669 chr16:420230 MRPL28 -0.49 -11.71 -0.42 7.97e-29 Bone mineral density (spine);Bone mineral density; BRCA cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg18876405 chr7:65276391 NA 0.51 11.55 0.42 3.58e-28 Aortic root size; BRCA trans rs61931739 0.517 rs1817760 chr12:34106060 A/G cg13010199 chr12:38710504 ALG10B 0.47 9.15 0.34 7.74e-19 Morning vs. evening chronotype; BRCA cis rs11758351 0.660 rs16891455 chr6:26230485 G/A cg01420254 chr6:26195488 NA 0.55 8.56 0.32 8.61e-17 Gout;Renal underexcretion gout; BRCA cis rs61990749 0.597 rs1978416 chr14:78227901 C/T cg23188588 chr14:78226832 SNW1;C14orf178 0.44 7.97 0.3 7.44e-15 Fibroblast growth factor basic levels; BRCA cis rs514406 0.505 rs269287 chr1:53168842 T/C cg08859206 chr1:53392774 SCP2 -0.41 -8.75 -0.33 1.96e-17 Monocyte count; BRCA trans rs2797160 1.000 rs1777222 chr6:126021030 C/T cg05039488 chr6:79577232 IRAK1BP1 0.36 8.25 0.31 9.21e-16 Endometrial cancer; BRCA cis rs1829883 0.835 rs2511961 chr5:98878673 A/G cg08333243 chr5:99726346 NA 0.34 8.16 0.31 1.79e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs10791323 0.628 rs2853117 chr11:133705266 T/G cg06766960 chr11:133703094 NA -0.61 -12.91 -0.45 4.99e-34 Childhood ear infection; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg16606324 chr3:10149918 C3orf24 0.48 9.47 0.35 5.5e-20 Alzheimer's disease; BRCA trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg16141378 chr3:129829833 LOC729375 -0.33 -8.4 -0.32 2.98e-16 Neuroticism; BRCA cis rs12477438 0.798 rs6542848 chr2:99573732 T/C cg08885076 chr2:99613938 TSGA10 -0.6 -13.45 -0.47 1.74e-36 Chronic sinus infection; BRCA cis rs875971 1.000 rs709595 chr7:65817333 G/C cg18876405 chr7:65276391 NA 0.55 13.2 0.46 2.49e-35 Aortic root size; BRCA cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.54 0.44 2.18e-32 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.560 rs4882325 chr12:38510037 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.33 -0.38 3.1e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg07308232 chr7:1071921 C7orf50 -0.47 -10.0 -0.37 5.64e-22 Longevity;Endometriosis; BRCA cis rs7666738 0.830 rs34461023 chr4:99023751 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.86 0.39 2.42e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6089584 1.000 rs6089584 chr20:60564086 G/C cg12751644 chr20:60527061 NA -0.33 -7.96 -0.3 7.71e-15 Body mass index; BRCA trans rs7980799 0.649 rs7972688 chr12:33653477 T/C cg26384229 chr12:38710491 ALG10B -0.47 -10.17 -0.37 1.26e-22 Heart rate;Heart rate variability traits (RMSSD); BRCA trans rs9388451 0.626 rs1739384 chr6:126099246 C/A cg05039488 chr6:79577232 IRAK1BP1 -0.52 -12.57 -0.45 1.56e-32 Brugada syndrome; BRCA cis rs1153858 1.000 rs7402650 chr15:45701895 C/T cg21132104 chr15:45694354 SPATA5L1 0.74 16.37 0.54 1.48e-50 Homoarginine levels; BRCA cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg26031613 chr14:104095156 KLC1 -0.43 -8.56 -0.32 8.44e-17 Schizophrenia; BRCA trans rs6089829 0.962 rs6062777 chr20:61663748 G/A cg17470723 chr8:74884337 TCEB1 0.41 8.87 0.33 7.36e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs12618769 0.652 rs3769701 chr2:99195111 A/C cg10123293 chr2:99228465 UNC50 0.43 8.53 0.32 1.05e-16 Bipolar disorder; BRCA cis rs477692 0.583 rs2008387 chr10:131448764 C/T cg05714579 chr10:131428358 MGMT -0.81 -22.14 -0.66 4.71e-81 Response to temozolomide; BRCA cis rs1707322 0.721 rs10430123 chr1:46221440 T/C cg03146154 chr1:46216737 IPP 0.54 12.03 0.43 3.34e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg03146154 chr1:46216737 IPP 0.47 10.26 0.38 5.77e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs747782 0.528 rs624348 chr11:48400795 G/A cg15704280 chr7:45808275 SEPT13 -0.55 -8.36 -0.31 3.98e-16 Intraocular pressure; BRCA cis rs6430585 0.528 rs309142 chr2:136715324 T/C cg07169764 chr2:136633963 MCM6 1.06 23.41 0.68 5.24e-88 Corneal structure; BRCA cis rs1153858 1.000 rs4775906 chr15:45638294 C/T cg21132104 chr15:45694354 SPATA5L1 0.7 15.45 0.52 5.52e-46 Homoarginine levels; BRCA cis rs13191362 0.872 rs13206549 chr6:162978032 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.83 11.91 0.43 1.14e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10751667 0.666 rs7103585 chr11:971166 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA trans rs3812049 0.693 rs9327468 chr5:127441861 C/A cg16011800 chr17:1958478 HIC1 -0.55 -8.77 -0.33 1.68e-17 Lymphocyte counts;Red cell distribution width; BRCA cis rs17376456 0.569 rs11948511 chr5:93286601 A/C cg25358565 chr5:93447407 FAM172A -0.52 -9.69 -0.36 7.93e-21 Diabetic retinopathy; BRCA cis rs10504229 1.000 rs67188507 chr8:58187492 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg05896524 chr21:47604654 C21orf56 0.5 9.82 0.36 2.75e-21 Testicular germ cell tumor; BRCA cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg25358565 chr5:93447407 FAM172A 1.21 18.93 0.6 8.69e-64 Diabetic retinopathy; BRCA cis rs9394152 0.810 rs9380364 chr6:33471721 T/C cg13560919 chr6:33536144 NA 0.62 12.76 0.45 2.26e-33 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs2243480 0.803 rs34804747 chr7:65412942 G/C cg18252515 chr7:66147081 NA -0.82 -11.87 -0.42 1.69e-29 Diabetic kidney disease; BRCA cis rs7727544 0.709 rs441969 chr5:131702120 G/A cg07395648 chr5:131743802 NA -0.37 -9.03 -0.34 1.95e-18 Blood metabolite levels; BRCA cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg15448220 chr1:150897856 SETDB1 0.35 7.82 0.3 2.16e-14 Melanoma; BRCA cis rs10751667 1.000 rs10794357 chr11:973374 T/C cg01483505 chr11:975446 AP2A2 0.35 9.22 0.34 4.3e-19 Alzheimer's disease (late onset); BRCA cis rs733592 1.000 rs1859440 chr12:48427329 T/C cg24011408 chr12:48396354 COL2A1 -0.44 -9.37 -0.35 1.22e-19 Plateletcrit; BRCA cis rs733592 0.507 rs10875739 chr12:48480919 C/T cg24011408 chr12:48396354 COL2A1 0.44 9.78 0.36 3.85e-21 Plateletcrit; BRCA cis rs7811142 1.000 rs28490152 chr7:100020982 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.28 0.59 2.27e-60 Platelet count; BRCA cis rs8141529 0.719 rs9625619 chr22:29272328 T/A cg15103426 chr22:29168792 CCDC117 0.52 12.03 0.43 3.59e-30 Lymphocyte counts; BRCA trans rs2197308 0.619 rs4002730 chr12:37876400 T/C cg06521331 chr12:34319734 NA -0.54 -9.73 -0.36 6.1e-21 Morning vs. evening chronotype; BRCA trans rs17685 0.753 rs4728586 chr7:75802869 T/C cg19862616 chr7:65841803 NCRNA00174 0.81 25.65 0.71 2.55e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11585357 0.947 rs11585119 chr1:17605792 C/A cg19159961 chr1:17633534 PADI4 0.57 8.9 0.33 5.53e-18 Hair shape; BRCA cis rs7301016 0.846 rs11174576 chr12:63026436 C/T cg11441379 chr12:63026424 NA 0.49 9.06 0.34 1.59e-18 IgG glycosylation; BRCA cis rs2832191 0.791 rs2832199 chr21:30498501 G/A cg08807101 chr21:30365312 RNF160 -0.58 -14.35 -0.49 1.13e-40 Dental caries; BRCA cis rs2559856 0.903 rs10128996 chr12:102081498 G/A cg12213457 chr12:102090980 CHPT1 -0.37 -8.05 -0.3 4.16e-15 Blood protein levels; BRCA cis rs2153535 0.580 rs1034272 chr6:8469335 G/C cg21535247 chr6:8435926 SLC35B3 0.4 9.0 0.34 2.61e-18 Motion sickness; BRCA cis rs11190604 1.000 rs10883508 chr10:102294413 G/A cg07080220 chr10:102295463 HIF1AN 0.62 14.54 0.5 1.42e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1355223 0.583 rs2956076 chr11:34874124 T/C cg11058730 chr11:34937778 PDHX;APIP 0.68 15.81 0.53 9.48e-48 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs16866061 0.515 rs13020268 chr2:225437923 C/T cg22455342 chr2:225449267 CUL3 0.33 8.9 0.33 5.92e-18 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg08742575 chr21:47604166 C21orf56 -0.4 -7.82 -0.3 2.2e-14 Testicular germ cell tumor; BRCA cis rs2032447 0.798 rs807212 chr6:26065621 A/G cg12310025 chr6:25882481 NA -0.54 -11.82 -0.42 2.76e-29 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs56168206 chr8:58184485 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs2882667 0.690 rs288030 chr5:138216283 A/G cg04439458 chr5:138467593 SIL1 -0.31 -7.99 -0.3 6.43e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13191362 1.000 rs34773528 chr6:163088796 G/C cg18825119 chr6:163149453 PACRG;PARK2 0.53 7.94 0.3 9.32e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7267979 0.966 rs2261747 chr20:25261784 G/A cg08601574 chr20:25228251 PYGB 0.36 8.65 0.32 4.06e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2645694 0.626 rs2703143 chr4:77830441 A/G cg10057126 chr4:77819792 ANKRD56 0.65 14.81 0.51 6.83e-43 Emphysema distribution in smoking; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg04025307 chr7:1156635 C7orf50 0.4 9.8 0.36 3.09e-21 Longevity;Endometriosis; BRCA cis rs2011503 0.882 rs56144632 chr19:19368310 G/A cg11584989 chr19:19387371 SF4 0.66 14.37 0.49 9.05e-41 Bipolar disorder; BRCA cis rs4689388 0.926 rs4416547 chr4:6293967 G/A cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs9462846 0.725 rs6927188 chr6:42912589 C/T cg13397359 chr6:42928475 GNMT -0.61 -11.44 -0.41 1.07e-27 Blood protein levels; BRCA cis rs780096 0.506 rs56076827 chr2:27676287 A/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.58 -0.32 7.19e-17 Total body bone mineral density; BRCA cis rs12893668 0.572 rs11540512 chr14:104147377 C/T cg08213375 chr14:104286397 PPP1R13B 0.41 8.85 0.33 8.76e-18 Reticulocyte count; BRCA cis rs10754283 0.967 rs7546518 chr1:90109956 C/T cg21401794 chr1:90099060 LRRC8C 0.5 11.76 0.42 4.96e-29 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg24531977 chr5:56204891 C5orf35 1.07 22.49 0.66 5.77e-83 Initial pursuit acceleration; BRCA cis rs2153535 0.580 rs2143354 chr6:8517907 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.88e-41 Motion sickness; BRCA cis rs3099143 1.000 rs3099134 chr15:77133168 T/G cg21673338 chr15:77095150 SCAPER -0.52 -9.23 -0.34 3.96e-19 Recalcitrant atopic dermatitis; BRCA cis rs701145 0.938 rs355747 chr3:153962973 T/C cg17054900 chr3:154042577 DHX36 0.67 11.71 0.42 8.15e-29 Coronary artery disease; BRCA cis rs1552244 1.000 rs3846177 chr3:10068572 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.64 -12.19 -0.43 6.83e-31 Alzheimer's disease; BRCA cis rs7555523 0.887 rs10918274 chr1:165714416 T/C cg24409356 chr1:165738333 TMCO1 0.51 8.21 0.31 1.23e-15 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg11814155 chr7:99998594 ZCWPW1 0.51 9.1 0.34 1.16e-18 Platelet count; BRCA cis rs12477438 0.520 rs13030961 chr2:99799520 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.12 0.67 2.18e-86 Chronic sinus infection; BRCA cis rs7412746 0.658 rs10305711 chr1:150802996 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.97 0.3 7.45e-15 Melanoma; BRCA cis rs926392 0.572 rs6129157 chr20:37672247 G/T cg16355469 chr20:37678765 NA 0.49 11.09 0.4 2.96e-26 Dialysis-related mortality; BRCA trans rs783540 1.000 rs803688 chr15:83216793 A/G cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.0 -0.3 5.84e-15 Schizophrenia; BRCA trans rs61931739 0.517 rs1817760 chr12:34106060 A/G cg26384229 chr12:38710491 ALG10B 0.67 14.05 0.49 2.98e-39 Morning vs. evening chronotype; BRCA cis rs9467773 0.572 rs13213953 chr6:26594534 T/A cg09904177 chr6:26538194 HMGN4 0.43 11.96 0.43 6.91e-30 Intelligence (multi-trait analysis); BRCA cis rs11690935 0.959 rs12692973 chr2:172642057 A/G cg13550731 chr2:172543902 DYNC1I2 0.91 30.25 0.77 1.86e-125 Schizophrenia; BRCA trans rs7618501 0.699 rs6446187 chr3:49907111 C/A cg21665057 chr3:196295764 WDR53;FBXO45 0.37 10.45 0.38 1.02e-23 Intelligence (multi-trait analysis); BRCA cis rs8180040 0.620 rs749511 chr3:47035735 A/C cg27129171 chr3:47204927 SETD2 -0.69 -16.62 -0.55 7.83e-52 Colorectal cancer; BRCA trans rs6951245 0.744 rs10265736 chr7:1172465 C/T cg13565492 chr6:43139072 SRF -0.84 -12.9 -0.45 5.51e-34 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35110281 0.782 rs2051407 chr21:45079245 T/C cg21573476 chr21:45109991 RRP1B -0.37 -9.32 -0.35 1.85e-19 Mean corpuscular volume; BRCA cis rs708547 0.647 rs1713982 chr4:57881715 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.37 9.76 0.36 4.61e-21 Response to bleomycin (chromatid breaks); BRCA trans rs61931739 0.534 rs1608912 chr12:34008574 C/T cg26384229 chr12:38710491 ALG10B 0.44 9.33 0.35 1.66e-19 Morning vs. evening chronotype; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.59 10.88 0.4 2.05e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs61931739 0.500 rs35030191 chr12:34548865 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg24768116 chr2:27665128 KRTCAP3 -0.33 -8.43 -0.32 2.33e-16 Total body bone mineral density; BRCA cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg12751644 chr20:60527061 NA -0.33 -7.95 -0.3 8.44e-15 Body mass index; BRCA cis rs769267 0.740 rs2965185 chr19:19525792 T/C cg11584989 chr19:19387371 SF4 0.33 8.26 0.31 8.6e-16 Tonsillectomy; BRCA cis rs7267979 0.966 rs2263204 chr20:25377688 A/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.44 -0.32 2.15e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6005807 0.719 rs9625514 chr22:29022188 T/C cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs7914558 0.966 rs10786719 chr10:104637992 C/T cg04362960 chr10:104952993 NT5C2 -0.42 -10.11 -0.37 2.08e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs4363385 0.720 rs1611754 chr1:152956415 A/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.72 -0.36 6.16e-21 Inflammatory skin disease; BRCA cis rs4975709 0.569 rs1684965 chr5:1865248 A/G cg20790798 chr5:1857306 NA -0.37 -8.6 -0.32 5.93e-17 Cardiovascular disease risk factors; BRCA cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.55 11.18 0.4 1.29e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs2153535 0.580 rs6941771 chr6:8494452 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.52 0.5 1.78e-41 Motion sickness; BRCA cis rs713587 0.525 rs1541984 chr2:25082414 G/A cg04586622 chr2:25135609 ADCY3 0.42 10.78 0.39 5.3e-25 Body mass index in non-asthmatics; BRCA cis rs2422052 0.639 rs1433531 chr2:118646201 A/C cg22545206 chr2:118617499 NA 0.38 9.4 0.35 9.57e-20 Mosquito bite size; BRCA cis rs13256369 0.802 rs13255789 chr8:8562791 T/C cg06671706 chr8:8559999 CLDN23 0.46 8.81 0.33 1.16e-17 Obesity-related traits; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg11814155 chr7:99998594 ZCWPW1 0.57 9.55 0.35 2.63e-20 Platelet count; BRCA trans rs1997103 1.000 rs6593237 chr7:55411015 T/C cg20935933 chr6:143382018 AIG1 0.59 11.39 0.41 1.76e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs703842 1.000 rs11172349 chr12:58212528 G/A cg18357645 chr12:58087776 OS9 -0.34 -8.26 -0.31 8.59e-16 Multiple sclerosis; BRCA cis rs2289583 0.503 rs113742359 chr15:75261643 A/G cg14664628 chr15:75095509 CSK 0.4 9.03 0.34 2.03e-18 Systemic lupus erythematosus; BRCA cis rs250677 0.522 rs17109208 chr5:148378475 G/A cg12140854 chr5:148520817 ABLIM3 -0.41 -8.39 -0.32 3.09e-16 Breast cancer; BRCA cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg14664628 chr15:75095509 CSK -0.93 -27.26 -0.73 3.77e-109 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg18305652 chr10:134549665 INPP5A -0.47 -10.99 -0.4 7.22e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg16339924 chr4:17578868 LAP3 0.58 14.07 0.49 2.4e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs78049276 0.736 rs72957606 chr4:148400011 A/G cg13149281 chr14:23389818 RBM23;PRMT5 -0.43 -7.9 -0.3 1.26e-14 Pulse pressure; BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg00024416 chr22:24240387 NA 0.47 11.21 0.41 9.45e-27 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs12995491 0.763 rs1914735 chr2:88511953 A/T cg14558114 chr2:88469736 THNSL2 -0.4 -8.75 -0.33 1.96e-17 Response to metformin (IC50); BRCA trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg22491629 chr6:157744540 C6orf35 -0.64 -12.25 -0.44 3.78e-31 Hemostatic factors and hematological phenotypes; BRCA cis rs12926788 0.542 rs6497759 chr16:24801737 G/A cg04756594 chr16:24857601 SLC5A11 0.54 12.07 0.43 2.34e-30 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs965469 1.000 rs6051809 chr20:3352551 A/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.54 -0.38 4.61e-24 IFN-related cytopenia; BRCA cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg13010199 chr12:38710504 ALG10B -0.38 -8.7 -0.33 2.89e-17 Morning vs. evening chronotype; BRCA cis rs12477438 0.520 rs4851187 chr2:99745860 G/T cg08885076 chr2:99613938 TSGA10 -0.44 -10.31 -0.38 3.66e-23 Chronic sinus infection; BRCA cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.75 -0.33 1.96e-17 Colorectal cancer; BRCA cis rs7267979 0.966 rs4813557 chr20:25292545 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.27 -0.34 2.88e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7737355 0.853 rs26005 chr5:130988029 A/G cg06307176 chr5:131281290 NA 0.56 12.09 0.43 1.93e-30 Life satisfaction; BRCA cis rs7412746 0.634 rs72704658 chr1:150833010 T/C cg17724175 chr1:150552817 MCL1 0.25 7.98 0.3 6.97e-15 Melanoma; BRCA cis rs2072499 0.966 rs2842864 chr1:156159217 G/A cg06970220 chr1:156163860 SLC25A44 0.39 9.45 0.35 6.4e-20 Testicular germ cell tumor; BRCA cis rs2439831 0.850 rs12441127 chr15:44021175 T/C cg27015174 chr15:43622946 ADAL;LCMT2 0.52 10.06 0.37 3.49e-22 Lung cancer in ever smokers; BRCA trans rs7939886 0.920 rs17150096 chr11:55902996 C/T cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs1862618 0.853 rs252904 chr5:56118733 A/T cg20203395 chr5:56204925 C5orf35 -0.49 -10.01 -0.37 5.06e-22 Initial pursuit acceleration; BRCA cis rs7011049 1.000 rs72643579 chr8:53846705 C/A cg26025543 chr8:53854495 NA 0.55 9.57 0.35 2.31e-20 Systolic blood pressure; BRCA cis rs6594499 0.872 rs7723819 chr5:110427347 A/G cg04022379 chr5:110408740 TSLP -0.35 -7.99 -0.3 6.3e-15 Allergic disease (asthma, hay fever or eczema); BRCA trans rs57221529 0.766 rs12518859 chr5:587432 C/T cg25482853 chr8:67687455 SGK3 1.05 16.53 0.55 2.24e-51 Lung disease severity in cystic fibrosis; BRCA cis rs9814567 1.000 rs6763093 chr3:134254995 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.728 rs17804335 chr8:58151428 G/T cg08219700 chr8:58056026 NA -0.54 -8.8 -0.33 1.23e-17 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg23978390 chr7:1156363 C7orf50 0.4 9.38 0.35 1.14e-19 Longevity;Endometriosis; BRCA cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA trans rs60843830 1.000 rs55946380 chr2:268293 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.75 0.5 1.34e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg20607798 chr8:58055168 NA 0.47 8.17 0.31 1.61e-15 Developmental language disorder (linguistic errors); BRCA cis rs7833986 0.534 rs2667972 chr8:56906661 C/T cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.57 0.45 1.6e-32 Height; BRCA cis rs12949688 1.000 rs886926 chr17:55817413 A/G cg12582317 chr17:55822272 NA -0.33 -7.94 -0.3 9.46e-15 Schizophrenia; BRCA cis rs801193 0.839 rs6968619 chr7:66068867 T/C cg18876405 chr7:65276391 NA -0.57 -13.62 -0.47 3e-37 Aortic root size; BRCA cis rs858239 0.570 rs10271613 chr7:23162586 G/A cg23682824 chr7:23144976 KLHL7 0.45 12.18 0.43 7.99e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs9788721 0.836 rs55983731 chr15:78735269 C/T cg18825076 chr15:78729989 IREB2 -0.4 -8.34 -0.31 4.52e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs2011503 1.000 rs2965178 chr19:19482911 T/G cg11584989 chr19:19387371 SF4 -0.56 -12.43 -0.44 6.14e-32 Bipolar disorder; BRCA cis rs7615952 0.599 rs12485717 chr3:125707075 C/T cg15145296 chr3:125709740 NA 0.52 8.25 0.31 9.29e-16 Blood pressure (smoking interaction); BRCA cis rs12410462 1.000 rs75198003 chr1:227623853 C/A cg04117972 chr1:227635322 NA 0.49 8.9 0.33 5.78e-18 Major depressive disorder; BRCA cis rs6089584 0.889 rs6142923 chr20:60596617 C/T cg06108461 chr20:60628389 TAF4 0.9 16.87 0.56 4.34e-53 Body mass index; BRCA cis rs62064224 0.902 rs17732573 chr17:30627664 C/T cg09324608 chr17:30823087 MYO1D -0.45 -9.8 -0.36 3.35e-21 Schizophrenia; BRCA cis rs1348850 0.914 rs8941 chr2:178406481 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.69 0.36 8.02e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.6 -12.71 -0.45 3.83e-33 Lymphocyte counts; BRCA cis rs7666738 0.830 rs11097609 chr4:99011707 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9467711 0.606 rs35076545 chr6:26603924 C/A cg12826209 chr6:26865740 GUSBL1 0.73 7.8 0.3 2.44e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.35 0.38 2.69e-23 Motion sickness; BRCA trans rs3960554 0.808 rs78478514 chr7:75655896 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 12.34 0.44 1.54e-31 Eotaxin levels; BRCA cis rs2239547 0.657 rs2276817 chr3:52860936 C/T cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 2.02e-19 Schizophrenia; BRCA cis rs9467773 1.000 rs6925703 chr6:26521589 G/A cg09904177 chr6:26538194 HMGN4 0.57 18.49 0.59 1.8e-61 Intelligence (multi-trait analysis); BRCA cis rs2559856 1.000 rs2251187 chr12:102081889 G/A cg12213457 chr12:102090980 CHPT1 -0.37 -8.03 -0.3 4.74e-15 Blood protein levels; BRCA cis rs796364 0.760 rs56285751 chr2:200919836 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.73 -11.12 -0.4 2.17e-26 Schizophrenia; BRCA cis rs5758511 0.680 rs5758692 chr22:42669029 T/A cg00645731 chr22:42541494 CYP2D7P1 0.56 10.71 0.39 9.87e-25 Birth weight; BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg11062466 chr8:58055876 NA 0.52 9.13 0.34 8.55e-19 Developmental language disorder (linguistic errors); BRCA cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.17 0.56 1.24e-54 Bladder cancer; BRCA cis rs9473147 0.543 rs9349417 chr6:47580657 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.58 0.35 2.15e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs4665809 0.549 rs3828255 chr2:26413252 G/A cg04944784 chr2:26401820 FAM59B 1.0 14.63 0.5 4.93e-42 Gut microbiome composition (summer); BRCA cis rs9837602 0.507 rs793448 chr3:99532949 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.68 -15.33 -0.52 2.04e-45 Breast cancer; BRCA cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.63 -14.9 -0.51 2.7e-43 Personality dimensions; BRCA cis rs7267979 1.000 rs6050630 chr20:25430745 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs586533 0.881 rs587925 chr11:99520831 A/G cg22878054 chr11:99397252 CNTN5 0.33 8.13 0.31 2.17e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs6878727 0.600 rs2619946 chr5:123641239 C/G cg01806427 chr5:123737813 NA -0.36 -8.0 -0.3 5.76e-15 Breast cancer; BRCA cis rs4727027 0.704 rs2269972 chr7:148914047 C/T cg23583168 chr7:148888333 NA 0.95 24.85 0.7 7.04e-96 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6831352 0.879 rs56272995 chr4:100060882 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.77 -0.42 4.32e-29 Alcohol dependence; BRCA cis rs35146811 0.586 rs10267231 chr7:99595480 T/C cg13334819 chr7:99746414 C7orf59 -0.36 -8.28 -0.31 7.36e-16 Coronary artery disease; BRCA cis rs6582630 0.555 rs6582503 chr12:38557886 A/C cg13010199 chr12:38710504 ALG10B 0.52 10.4 0.38 1.62e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs34779708 0.677 rs112355105 chr10:35550294 A/T cg03585969 chr10:35415529 CREM 0.43 8.65 0.32 4.22e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg11789530 chr4:8429930 ACOX3 -0.68 -17.77 -0.58 9.83e-58 Response to antineoplastic agents; BRCA cis rs2295359 0.824 rs4655679 chr1:67599657 A/G cg03340356 chr1:67600835 NA -0.35 -7.9 -0.3 1.25e-14 Psoriasis; BRCA cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg12350822 chr6:88032061 C6orf162;GJB7 0.38 11.23 0.41 7.91e-27 Monocyte percentage of white cells; BRCA cis rs7927771 0.800 rs11039200 chr11:47379646 A/C cg18512352 chr11:47633146 NA -0.35 -8.24 -0.31 9.78e-16 Subjective well-being; BRCA cis rs13191362 1.000 rs73035012 chr6:162997279 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.86 13.54 0.47 6.44e-37 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs34779708 0.966 rs4294520 chr10:35422506 C/T cg03585969 chr10:35415529 CREM 0.55 11.37 0.41 2.17e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13046373 0.505 rs2832934 chr21:31899760 A/G cg24082983 chr21:31802169 KRTAP13-4 0.36 8.88 0.33 6.49e-18 HDL cholesterol; BRCA cis rs4665809 1.000 rs6546736 chr2:26293878 C/T cg08470875 chr2:26401718 FAM59B 0.51 8.29 0.31 6.69e-16 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg12379764 chr21:47803548 PCNT -0.61 -12.22 -0.44 5.46e-31 Testicular germ cell tumor; BRCA cis rs6860806 0.507 rs635619 chr5:131720265 G/A cg07395648 chr5:131743802 NA 0.37 7.99 0.3 6.21e-15 Breast cancer; BRCA cis rs4819052 0.851 rs2838840 chr21:46668494 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.76 0.36 4.39e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs769267 0.965 rs2023882 chr19:19405405 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.57 0.39 3.41e-24 Tonsillectomy; BRCA cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg13010199 chr12:38710504 ALG10B 0.4 8.34 0.31 4.52e-16 Bladder cancer; BRCA cis rs7582180 0.627 rs2241811 chr2:101011724 C/T cg14675211 chr2:100938903 LONRF2 0.43 9.62 0.36 1.54e-20 Intelligence (multi-trait analysis); BRCA cis rs2011503 1.000 rs75667002 chr19:19592232 T/A cg11584989 chr19:19387371 SF4 0.63 13.58 0.47 4.17e-37 Bipolar disorder; BRCA cis rs796364 0.806 rs74771155 chr2:200913743 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs72781680 0.846 rs55770503 chr2:24030126 A/T cg20701182 chr2:24300061 SF3B14 0.56 8.72 0.33 2.3e-17 Lymphocyte counts; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 9.55 0.35 2.67e-20 Longevity;Endometriosis; BRCA trans rs3733585 0.673 rs4407505 chr4:9953367 T/G cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs72781680 0.898 rs72782106 chr2:24022009 A/G cg08917208 chr2:24149416 ATAD2B 1.05 14.36 0.49 9.8e-41 Lymphocyte counts; BRCA cis rs12612619 0.579 rs827884 chr2:27094842 C/G cg12368169 chr2:27073192 DPYSL5 -0.31 -9.14 -0.34 8.4e-19 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.3e-19 Tonsillectomy; BRCA cis rs9443645 0.527 rs10943595 chr6:79575291 C/G cg05283184 chr6:79620031 NA -0.36 -8.35 -0.31 4.12e-16 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.611 rs34982650 chr4:98819530 T/A cg17366294 chr4:99064904 C4orf37 0.44 10.22 0.37 8.18e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6684514 1.000 rs12118238 chr1:156235221 G/A cg16558208 chr1:156270281 VHLL 0.37 8.21 0.31 1.19e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs896854 0.654 rs28716845 chr8:95974485 A/G cg26343298 chr8:95960752 TP53INP1 0.3 8.74 0.33 2.07e-17 Type 2 diabetes; BRCA trans rs3812049 0.667 rs6888037 chr5:127406259 G/T cg16011800 chr17:1958478 HIC1 -0.54 -8.69 -0.33 3.08e-17 Lymphocyte counts;Red cell distribution width; BRCA cis rs35110281 0.600 rs11089092 chr21:45120994 A/C cg04455712 chr21:45112962 RRP1B 0.43 11.5 0.41 5.74e-28 Mean corpuscular volume; BRCA cis rs7618915 0.501 rs767418 chr3:52767427 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.85 0.45 8.83e-34 Bipolar disorder; BRCA cis rs7399018 0.739 rs10747608 chr12:51616582 A/G cg25754956 chr12:51612065 POU6F1 0.79 17.34 0.57 1.77e-55 Cisplatin-induced ototoxicity; BRCA cis rs1005277 0.579 rs2474588 chr10:38420870 A/G cg00409905 chr10:38381863 ZNF37A -0.51 -10.84 -0.39 3.13e-25 Extrinsic epigenetic age acceleration; BRCA cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.46 9.62 0.36 1.54e-20 Tonsillectomy; BRCA cis rs2304069 0.779 rs245080 chr5:149354805 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.53 -11.34 -0.41 2.71e-27 HIV-1 control; BRCA cis rs68170813 0.559 rs10953536 chr7:107021691 G/A cg02696742 chr7:106810147 HBP1 -0.56 -8.66 -0.32 3.78e-17 Coronary artery disease; BRCA cis rs1904096 0.506 rs13435702 chr4:95167751 G/A cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.07 -0.37 3.06e-22 Type 2 diabetes; BRCA cis rs1506636 1.000 rs652497 chr7:123423671 G/T cg03229431 chr7:123269106 ASB15 0.61 13.54 0.47 6.54e-37 Plateletcrit;Platelet count; BRCA trans rs7824557 0.650 rs2572406 chr8:11092252 C/G cg06636001 chr8:8085503 FLJ10661 0.38 8.21 0.31 1.19e-15 Retinal vascular caliber; BRCA trans rs11098499 0.532 rs4504231 chr4:120586891 G/A cg25214090 chr10:38739885 LOC399744 0.47 10.51 0.38 6.02e-24 Corneal astigmatism; BRCA cis rs3125734 0.633 rs4979773 chr10:63967731 G/C cg09941381 chr10:64027924 RTKN2 -0.29 -8.76 -0.33 1.81e-17 Rheumatoid arthritis; BRCA cis rs12950390 0.853 rs11655336 chr17:45858836 A/G cg24803719 chr17:45855879 NA 0.32 8.44 0.32 2.15e-16 IgG glycosylation; BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg18765753 chr7:1198926 ZFAND2A -0.51 -12.84 -0.45 9.41e-34 Longevity;Endometriosis; BRCA cis rs798554 0.660 rs2283783 chr7:2855326 G/A cg19717773 chr7:2847554 GNA12 -0.43 -9.5 -0.35 4.24e-20 Height; BRCA cis rs1008375 0.897 rs2315554 chr4:17660407 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.37 0.31 3.53e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9469578 1.000 rs9469581 chr6:33715904 C/A cg18708504 chr6:33715942 IP6K3 0.68 9.99 0.37 6.04e-22 Phosphorus levels; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.25e-20 Total body bone mineral density; BRCA cis rs2439831 0.850 rs16950562 chr15:44036364 G/A cg10011062 chr15:43941034 CATSPER2 -0.59 -8.94 -0.33 4.31e-18 Lung cancer in ever smokers; BRCA trans rs4650994 0.525 rs4650996 chr1:178517365 A/G cg05059571 chr16:84539110 KIAA1609 -0.58 -12.94 -0.46 3.37e-34 HDL cholesterol levels;HDL cholesterol; BRCA cis rs1595825 0.891 rs73054817 chr2:198623751 A/G cg19156104 chr2:198669113 PLCL1 -0.44 -8.33 -0.31 4.87e-16 Ulcerative colitis; BRCA cis rs7615952 0.866 rs11922276 chr3:125631326 G/T cg05084668 chr3:125655381 ALG1L -0.55 -9.0 -0.34 2.63e-18 Blood pressure (smoking interaction); BRCA cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg00108164 chr2:264199 ACP1;SH3YL1 0.7 14.18 0.49 7.13e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6582630 0.622 rs11831595 chr12:38511489 C/A cg26384229 chr12:38710491 ALG10B -0.43 -10.06 -0.37 3.25e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs965469 1.000 rs6051703 chr20:3252347 A/T cg25506879 chr20:3388711 C20orf194 -0.55 -10.79 -0.39 4.75e-25 IFN-related cytopenia; BRCA cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.43 0.35 7.61e-20 Tonsillectomy; BRCA cis rs7264396 0.635 rs6060709 chr20:34536022 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.04 0.3 4.33e-15 Total cholesterol levels; BRCA cis rs8031584 0.958 rs11637469 chr15:31238783 T/C cg08704250 chr15:31115839 NA -0.36 -9.13 -0.34 9e-19 Huntington's disease progression; BRCA trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21659725 chr3:3221576 CRBN 0.7 20.95 0.64 1.37e-74 Intelligence (multi-trait analysis); BRCA cis rs870825 0.698 rs7673203 chr4:185625397 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs1577917 0.798 rs7772384 chr6:86639680 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -13.18 -0.46 2.84e-35 Response to antipsychotic treatment; BRCA cis rs10899021 0.920 rs7112384 chr11:74348205 T/G cg25880958 chr11:74394337 NA -0.49 -7.88 -0.3 1.43e-14 Response to metformin (IC50); BRCA cis rs7385804 0.761 rs504141 chr7:100309125 G/A cg20848291 chr7:100343083 ZAN 0.37 8.32 0.31 5.39e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs875971 1.000 rs2420168 chr7:65630631 C/G cg18876405 chr7:65276391 NA -0.56 -13.42 -0.47 2.42e-36 Aortic root size; BRCA cis rs2204008 0.528 rs11503820 chr12:38395379 G/A cg26384229 chr12:38710491 ALG10B -0.42 -9.83 -0.36 2.48e-21 Bladder cancer; BRCA cis rs2243480 1.000 rs7787230 chr7:65629099 G/A cg18252515 chr7:66147081 NA 1.03 15.25 0.52 5.04e-45 Diabetic kidney disease; BRCA cis rs1005277 0.579 rs2505197 chr10:38393310 T/C cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs9837602 0.507 rs793452 chr3:99529523 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.38 -8.47 -0.32 1.63e-16 Breast cancer; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs9462027 0.583 rs9469862 chr6:34729848 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.99 -0.3 6.37e-15 Systemic lupus erythematosus; BRCA cis rs262150 0.731 rs2657388 chr7:158763428 A/G cg09640425 chr7:158790006 NA 0.37 7.87 0.3 1.48e-14 Facial morphology (factor 20); BRCA cis rs2742234 0.504 rs10899780 chr10:43725796 T/C cg02780029 chr10:43622663 RET 0.35 7.9 0.3 1.26e-14 Hirschsprung disease; BRCA cis rs2832077 0.689 rs2832052 chr21:30130073 G/C cg08807101 chr21:30365312 RNF160 -0.4 -8.12 -0.31 2.44e-15 Cognitive test performance; BRCA trans rs1005277 0.529 rs1780125 chr10:38531376 A/G cg23533926 chr12:111358616 MYL2 -0.44 -9.2 -0.34 4.98e-19 Extrinsic epigenetic age acceleration; BRCA cis rs4319547 0.695 rs4758643 chr12:122924819 A/T cg23029597 chr12:123009494 RSRC2 -0.61 -11.79 -0.42 3.46e-29 Body mass index; BRCA trans rs10411161 0.702 rs11878583 chr19:52388546 C/T cg22319618 chr22:45562946 NUP50 0.42 7.99 0.3 6.51e-15 Breast cancer; BRCA cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg06238570 chr21:40685208 BRWD1 -0.41 -8.13 -0.31 2.17e-15 Menarche (age at onset); BRCA trans rs7200543 1.000 rs4985124 chr16:15125441 A/C cg24683922 chr1:11983373 KIAA2013 -0.36 -8.19 -0.31 1.46e-15 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs360798 0.512 rs11893131 chr2:63079528 C/A cg17519650 chr2:63277830 OTX1 0.38 8.36 0.31 3.94e-16 Coronary artery disease; BRCA trans rs2562456 0.724 rs58001930 chr19:21742863 C/T cg25042112 chr7:64838748 ZNF92 -0.45 -8.27 -0.31 8.04e-16 Pain; BRCA trans rs747782 0.528 rs7937670 chr11:48313216 C/T cg15704280 chr7:45808275 SEPT13 0.54 8.15 0.31 1.9e-15 Intraocular pressure; BRCA cis rs11599315 0.507 rs12217329 chr10:1341897 A/G cg09624528 chr10:1369823 ADARB2 0.41 8.47 0.32 1.71e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs60871478 1.000 rs7795258 chr7:795227 A/G cg04727924 chr7:799746 HEATR2 -0.52 -10.58 -0.39 3.1e-24 Cerebrospinal P-tau181p levels; BRCA cis rs877282 0.945 rs12776447 chr10:790625 A/G cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.62 0.32 5.14e-17 Diabetic retinopathy; BRCA cis rs9463078 0.547 rs34907292 chr6:44729708 A/G cg25276700 chr6:44698697 NA 0.36 8.31 0.31 5.7e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs490234 0.691 rs3104551 chr9:128164279 G/A cg14078157 chr9:128172775 NA -0.37 -8.1 -0.31 2.87e-15 Mean arterial pressure; BRCA cis rs72928364 0.860 rs62274066 chr3:100801179 A/C cg10123952 chr3:100791384 NA 0.57 8.28 0.31 7.2e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs4713675 0.584 rs7759668 chr6:33670406 C/T cg14003231 chr6:33640908 ITPR3 -0.32 -7.84 -0.3 1.91e-14 Plateletcrit; BRCA cis rs4819052 0.851 rs2330011 chr21:46658498 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.53 11.52 0.41 4.94e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9393777 0.513 rs6936555 chr6:26640886 C/T cg12826209 chr6:26865740 GUSBL1 0.59 10.31 0.38 3.81e-23 Intelligence (multi-trait analysis); BRCA cis rs13082711 0.595 rs6783818 chr3:27361988 C/G cg02860705 chr3:27208620 NA 0.78 14.39 0.49 6.76e-41 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA trans rs8002861 0.664 rs2184882 chr13:44450346 C/T cg17145862 chr1:211918768 LPGAT1 0.48 10.9 0.4 1.8e-25 Leprosy; BRCA cis rs4481887 0.927 rs10888344 chr1:248446655 T/C cg00666640 chr1:248458726 OR2T12 0.31 8.46 0.32 1.77e-16 Common traits (Other); BRCA cis rs780096 0.527 rs12471703 chr2:27738854 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.39 -0.32 3.01e-16 Total body bone mineral density; BRCA cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg12011299 chr4:100065546 ADH4 0.53 12.95 0.46 3.03e-34 Alcohol dependence; BRCA cis rs6430585 0.527 rs59413285 chr2:136444185 G/T cg07169764 chr2:136633963 MCM6 1.0 19.33 0.61 6.73e-66 Corneal structure; BRCA cis rs7809950 0.953 rs28687365 chr7:107106712 A/C cg23024343 chr7:107201750 COG5 -0.41 -9.38 -0.35 1.1e-19 Coronary artery disease; BRCA cis rs11605924 0.901 rs6485644 chr11:45855998 C/T ch.11.939596F chr11:45881766 CRY2 -0.45 -9.68 -0.36 9.35e-21 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs74181299 1.000 rs74181299 chr2:65283972 T/C cg05010058 chr2:65284262 CEP68 0.32 8.83 0.33 9.93e-18 Pulse pressure; BRCA cis rs1801251 0.711 rs778339 chr2:233739678 T/C cg08000102 chr2:233561755 GIGYF2 -0.46 -9.98 -0.37 6.79e-22 Coronary artery disease; BRCA cis rs7666738 0.830 rs10022331 chr4:98960392 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs7123876 0.553 rs10898868 chr11:72431679 A/G cg03713592 chr11:72463424 ARAP1 0.42 8.0 0.3 5.69e-15 Body mass index; BRCA cis rs2760061 0.626 rs2313118 chr1:228118084 T/C cg02753203 chr1:228287806 NA -0.57 -12.05 -0.43 2.8e-30 Diastolic blood pressure; BRCA cis rs10493773 0.510 rs11161645 chr1:86092872 T/C cg17807903 chr1:86174739 ZNHIT6 0.35 7.88 0.3 1.37e-14 Urate levels in overweight individuals; BRCA cis rs2153535 0.580 rs9379206 chr6:8458021 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg21782813 chr7:2030301 MAD1L1 0.3 8.25 0.31 8.81e-16 Bipolar disorder and schizophrenia; BRCA cis rs614226 1.000 rs1614223 chr12:120964043 T/C cg27489772 chr12:121021490 NA 0.44 7.95 0.3 8.79e-15 Type 1 diabetes nephropathy; BRCA cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg16989086 chr20:62203971 PRIC285 0.54 9.15 0.34 7.51e-19 Glioblastoma; BRCA cis rs765787 0.530 rs4775822 chr15:45527127 A/G cg24006582 chr15:45444508 DUOX1 -0.53 -10.98 -0.4 7.9e-26 Uric acid levels; BRCA cis rs7659604 0.539 rs7686084 chr4:122764725 A/C cg20573242 chr4:122745356 CCNA2 0.48 10.69 0.39 1.14e-24 Type 2 diabetes; BRCA cis rs4953318 0.619 rs10183887 chr2:46361808 T/A cg12428440 chr2:46370979 PRKCE 0.49 10.76 0.39 6.19e-25 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs2354432 0.607 rs6593751 chr1:146726023 A/G cg25205988 chr1:146714368 CHD1L -0.97 -12.75 -0.45 2.59e-33 Mitochondrial DNA levels; BRCA cis rs7945718 0.839 rs10831911 chr11:12834858 C/T cg25843174 chr11:12811716 TEAD1 0.21 8.24 0.31 9.88e-16 Educational attainment (years of education); BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg12444411 chr7:2802554 GNA12 -0.35 -8.33 -0.31 4.86e-16 Height; BRCA cis rs7851660 0.967 rs10046805 chr9:100613956 G/A cg13688889 chr9:100608707 NA -0.36 -8.71 -0.33 2.56e-17 Strep throat; BRCA cis rs9287719 0.967 rs12464908 chr2:10761496 T/G cg02196655 chr2:10830764 NOL10 -0.3 -7.87 -0.3 1.52e-14 Prostate cancer; BRCA cis rs7766436 0.767 rs6456496 chr6:22599386 G/C cg13666174 chr6:22585274 NA -0.37 -9.58 -0.35 2.11e-20 Coronary artery disease; BRCA cis rs7799006 0.582 rs7781284 chr7:2339405 G/T cg08027265 chr7:2291960 NA -0.37 -9.8 -0.36 3.23e-21 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2070997 0.816 rs1800609 chr9:133731184 A/G cg11464064 chr9:133710261 ABL1 0.54 8.87 0.33 7.55e-18 Response to amphetamines; BRCA cis rs35110281 0.776 rs229357 chr21:44982717 T/C cg04455712 chr21:45112962 RRP1B 0.38 9.63 0.36 1.39e-20 Mean corpuscular volume; BRCA cis rs13118159 1.000 rs13118159 chr4:1365127 A/G cg20887711 chr4:1340912 KIAA1530 0.41 9.66 0.36 1.04e-20 Longevity; BRCA cis rs9325144 0.560 rs7980635 chr12:38668355 G/T cg26384229 chr12:38710491 ALG10B -0.54 -13.47 -0.47 1.4e-36 Morning vs. evening chronotype; BRCA cis rs2153535 0.601 rs2327091 chr6:8540369 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.57 0.32 7.83e-17 Motion sickness; BRCA cis rs10992471 0.627 rs4744138 chr9:95291909 A/G cg14631576 chr9:95140430 CENPP -0.36 -8.5 -0.32 1.31e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs17401966 0.931 rs4240911 chr1:10307453 A/G cg19773385 chr1:10388646 KIF1B -0.36 -8.35 -0.31 4.13e-16 Hepatocellular carcinoma; BRCA cis rs6740322 0.895 rs10210125 chr2:43556433 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -11.9 -0.43 1.23e-29 Coronary artery disease; BRCA cis rs10465746 0.687 rs6576954 chr1:84323701 C/T cg10977910 chr1:84465055 TTLL7 -0.43 -8.11 -0.31 2.68e-15 Obesity-related traits; BRCA cis rs1552244 0.882 rs9757159 chr3:10039166 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.63 -11.79 -0.42 3.7e-29 Alzheimer's disease; BRCA cis rs4919694 0.611 rs2271750 chr10:105174869 A/G cg04362960 chr10:104952993 NT5C2 -0.64 -11.04 -0.4 4.49e-26 Arsenic metabolism; BRCA cis rs507080 0.885 rs693037 chr11:118553326 C/T cg08498647 chr11:118550644 TREH -0.38 -8.35 -0.31 4.11e-16 Serum metabolite levels; BRCA cis rs17253792 0.915 rs74580958 chr14:56181511 G/A cg01858014 chr14:56050164 KTN1 -0.68 -8.36 -0.31 3.99e-16 Putamen volume; BRCA cis rs17401966 0.931 rs12131441 chr1:10428952 G/A cg03954927 chr1:10346856 KIF1B 0.48 14.82 0.51 6.34e-43 Hepatocellular carcinoma; BRCA cis rs1499614 1.000 rs1882655 chr7:66147057 T/C cg18252515 chr7:66147081 NA 1.07 15.95 0.53 1.77e-48 Gout; BRCA cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.95 -0.33 3.97e-18 Developmental language disorder (linguistic errors); BRCA cis rs2075371 1.000 rs2075373 chr7:133984683 A/C cg11752832 chr7:134001865 SLC35B4 0.52 13.42 0.47 2.36e-36 Mean platelet volume; BRCA cis rs9473147 0.516 rs6904764 chr6:47503497 A/T cg12968598 chr6:47444699 CD2AP 0.44 9.71 0.36 7.19e-21 Platelet distribution width;Mean platelet volume; BRCA trans rs7618501 1.000 rs9872864 chr3:49792023 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.52 -16.22 -0.54 8.53e-50 Intelligence (multi-trait analysis); BRCA cis rs2075671 0.857 rs11772849 chr7:100308412 G/A cg20848291 chr7:100343083 ZAN -0.61 -13.15 -0.46 3.81e-35 Other erythrocyte phenotypes; BRCA cis rs2011503 0.943 rs8100927 chr19:19643636 C/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs2731664 0.756 rs335433 chr5:176867207 T/C cg23176889 chr5:176863531 GRK6 -0.59 -15.51 -0.52 2.74e-46 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.501 rs62253740 chr3:52684128 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.23 -0.31 1.08e-15 Bipolar disorder; BRCA cis rs10754283 0.901 rs6663526 chr1:90110862 T/C cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg00106254 chr7:1943704 MAD1L1 -0.39 -9.45 -0.35 6.3e-20 Bipolar disorder and schizophrenia; BRCA cis rs35995292 0.534 rs917322 chr7:38943165 A/T cg19327137 chr7:38886074 VPS41 -0.38 -12.64 -0.45 7.31e-33 Subjective well-being (multi-trait analysis); BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg20007245 chr22:24372913 LOC391322 -0.54 -11.98 -0.43 5.45e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs909341 0.710 rs6089953 chr20:62291008 C/T cg03425785 chr20:62221387 GMEB2 0.54 8.83 0.33 1.03e-17 Atopic dermatitis; BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.54 -0.32 9.96e-17 Total body bone mineral density; BRCA cis rs7927771 0.507 rs7119517 chr11:47675316 T/C cg20307385 chr11:47447363 PSMC3 0.42 9.62 0.36 1.52e-20 Subjective well-being; BRCA cis rs13217239 0.646 rs12201393 chr6:26975690 C/A cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Schizophrenia; BRCA cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg18132916 chr6:79620363 NA -0.44 -10.07 -0.37 3.15e-22 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.664 rs28602527 chr4:9958327 G/A cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4073582 0.576 rs556595 chr11:66058082 T/G cg16950941 chr11:66035639 RAB1B 0.44 11.58 0.42 2.87e-28 Gout; BRCA cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.08 -0.34 1.32e-18 Bipolar disorder; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -11.47 -0.41 8.06e-28 Platelet count; BRCA cis rs9296092 0.560 rs3846853 chr6:33528194 C/G cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs884366 0.724 rs4946960 chr6:109641677 A/G cg01475377 chr6:109611718 NA 0.36 7.92 0.3 1.08e-14 HDL cholesterol levels;HDL cholesterol; BRCA cis rs10911363 0.592 rs2702205 chr1:183457198 A/G cg09173681 chr1:183549694 NCF2 0.49 10.7 0.39 1.05e-24 Systemic lupus erythematosus; BRCA cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg03676636 chr4:99064102 C4orf37 0.23 8.2 0.31 1.29e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 1.000 rs58601355 chr4:120186367 T/C cg09307838 chr4:120376055 NA 0.63 12.64 0.45 7.35e-33 Corneal astigmatism; BRCA cis rs13082711 0.595 rs62255583 chr3:27309704 G/T cg02860705 chr3:27208620 NA 0.78 14.4 0.49 6.51e-41 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs66569888 0.789 rs17213510 chr2:106742778 T/C cg15412446 chr2:106886593 NA -0.48 -8.2 -0.31 1.33e-15 Facial morphology (factor 23); BRCA cis rs7131987 0.650 rs16934135 chr12:29483963 T/G cg09582351 chr12:29534625 ERGIC2 -0.45 -10.41 -0.38 1.46e-23 QT interval; BRCA trans rs35110281 0.807 rs6518301 chr21:45016818 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.48 0.32 1.57e-16 Mean corpuscular volume; BRCA cis rs11098499 0.754 rs1980026 chr4:120251643 C/A cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs7586673 0.866 rs7579662 chr2:161915810 G/A cg21518248 chr2:162101506 NA 0.42 8.64 0.32 4.62e-17 Intelligence (multi-trait analysis); BRCA cis rs10949834 0.529 rs150861 chr7:73524901 T/C cg07137043 chr7:73588983 EIF4H 0.51 8.81 0.33 1.15e-17 Verbal memory performance (residualized delayed recall change); BRCA cis rs35306767 0.953 rs11253517 chr10:970524 A/G cg25019033 chr10:957182 NA 0.43 8.35 0.31 4.15e-16 Eosinophil percentage of granulocytes; BRCA cis rs12477438 1.000 rs12053372 chr2:99810055 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.78 -16.37 -0.54 1.44e-50 Chronic sinus infection; BRCA cis rs9733 0.596 rs34600506 chr1:150687808 C/G cg04414720 chr1:150670196 GOLPH3L 0.35 8.04 0.3 4.33e-15 Tonsillectomy; BRCA cis rs514406 0.505 rs431427 chr1:53179094 C/A cg16325326 chr1:53192061 ZYG11B 0.9 25.11 0.7 2.37e-97 Monocyte count; BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA cis rs9467711 0.591 rs35335639 chr6:26038681 C/G cg08501292 chr6:25962987 TRIM38 0.58 7.87 0.3 1.52e-14 Autism spectrum disorder or schizophrenia; BRCA trans rs6561151 0.957 rs3764147 chr13:44457925 C/T cg12856521 chr11:46389249 DGKZ -0.44 -8.96 -0.33 3.5e-18 Crohn's disease; BRCA cis rs17376456 0.825 rs28610997 chr5:93248374 T/C cg21475434 chr5:93447410 FAM172A 0.67 8.51 0.32 1.24e-16 Diabetic retinopathy; BRCA cis rs941873 0.803 rs5015119 chr10:81101609 G/C cg09469691 chr10:81107165 PPIF 0.53 11.01 0.4 6.33e-26 Height; BRCA trans rs79976124 0.719 rs34488909 chr6:66637850 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.96 0.4 9.84e-26 Type 2 diabetes; BRCA cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg04267008 chr7:1944627 MAD1L1 -0.53 -12.27 -0.44 3.27e-31 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.906 rs58559296 chr8:58171714 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs2839186 0.771 rs2280959 chr21:47641996 C/G cg11766577 chr21:47581405 C21orf56 -0.5 -10.79 -0.39 4.75e-25 Testicular germ cell tumor; BRCA cis rs1580019 0.961 rs1868777 chr7:32494076 C/T cg06627557 chr7:32535165 LSM5;AVL9 0.7 14.32 0.49 1.57e-40 Cognitive ability; BRCA cis rs1707322 0.717 rs11211161 chr1:46148138 A/C cg06784218 chr1:46089804 CCDC17 0.51 12.27 0.44 3.26e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12477438 0.520 rs6708576 chr2:99801308 G/A cg08885076 chr2:99613938 TSGA10 0.46 10.69 0.39 1.19e-24 Chronic sinus infection; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg27588902 chr6:42928151 GNMT -0.31 -10.59 -0.39 3.07e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs495337 1.000 rs6125826 chr20:48556461 C/T cg17835207 chr20:48524531 SPATA2 -0.6 -13.74 -0.48 8e-38 Psoriasis; BRCA cis rs17345786 1.000 rs3804778 chr3:101294572 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 8.91 0.33 5.17e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs2482930 chr20:25334115 G/C cg08601574 chr20:25228251 PYGB -0.38 -9.03 -0.34 2.02e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs250677 0.687 rs250673 chr5:148445798 C/T cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.89e-31 Breast cancer; BRCA trans rs9951602 0.512 rs1599634 chr18:76643645 T/C cg02800362 chr5:177631904 HNRNPAB 0.75 17.49 0.57 2.96e-56 Obesity-related traits; BRCA cis rs35110281 0.744 rs162398 chr21:44949285 T/C cg04455712 chr21:45112962 RRP1B 0.42 10.99 0.4 7.27e-26 Mean corpuscular volume; BRCA cis rs477895 0.652 rs72920332 chr11:63947071 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.15 0.31 1.86e-15 Mean platelet volume; BRCA cis rs1577917 0.958 rs12199832 chr6:86652748 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.87 -0.43 1.6e-29 Response to antipsychotic treatment; BRCA cis rs1003719 1.000 rs2835607 chr21:38491973 T/G cg10648535 chr21:38446584 PIGP;TTC3 0.62 14.18 0.49 7.02e-40 Eye color traits; BRCA cis rs1862618 0.802 rs832547 chr5:56183941 C/G cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.41e-39 Initial pursuit acceleration; BRCA cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg18404041 chr3:52824283 ITIH1 -0.39 -11.97 -0.43 6.16e-30 Bipolar disorder; BRCA cis rs2806561 0.514 rs7414010 chr1:23543929 T/C cg19743168 chr1:23544995 NA 0.69 17.18 0.56 1.16e-54 Height; BRCA trans rs6076960 0.684 rs3844461 chr20:6253115 G/A cg21095983 chr6:86352623 SYNCRIP 0.4 9.0 0.34 2.63e-18 Smooth-surface caries; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg16145915 chr7:1198662 ZFAND2A -0.68 -18.43 -0.59 3.98e-61 Longevity;Endometriosis; BRCA cis rs758324 0.738 rs413185 chr5:131315225 A/G cg06307176 chr5:131281290 NA 0.51 10.85 0.39 2.75e-25 Alzheimer's disease in APOE e4- carriers; BRCA trans rs3733585 0.699 rs7676733 chr4:9966956 G/A cg26043149 chr18:55253948 FECH -0.38 -8.34 -0.31 4.43e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7027203 0.688 rs4075733 chr9:96624645 C/T cg14598338 chr9:96623480 NA -0.32 -7.86 -0.3 1.61e-14 DNA methylation (variation); BRCA cis rs6500602 0.627 rs2270363 chr16:4526292 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.42 8.78 0.33 1.54e-17 Schizophrenia; BRCA cis rs9811920 0.609 rs793466 chr3:99609837 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs17095355 1.000 rs12569906 chr10:111706856 A/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -9.97 -0.37 7.61e-22 Biliary atresia; BRCA cis rs6714710 0.603 rs13020776 chr2:98402753 T/A cg26665480 chr2:98280029 ACTR1B 0.58 13.59 0.47 4.06e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7523273 0.606 rs2796266 chr1:207922945 C/T cg22525895 chr1:207977042 MIR29B2 -0.48 -12.08 -0.43 1.99e-30 Schizophrenia; BRCA trans rs6582630 0.555 rs11182193 chr12:38474090 C/G cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7020830 0.898 rs12000309 chr9:37230844 G/A cg14294708 chr9:37120828 ZCCHC7 1.16 42.1 0.86 1.93e-186 Schizophrenia; BRCA cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 14.45 0.5 3.6e-41 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs10017201 chr4:98983561 G/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs7103648 0.712 rs10838703 chr11:47422861 C/G cg20307385 chr11:47447363 PSMC3 0.76 17.93 0.58 1.5e-58 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.58e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg21775007 chr8:11205619 TDH 0.45 9.39 0.35 1.02e-19 Neuroticism; BRCA cis rs9787249 0.957 rs3738673 chr1:40204823 C/T cg02773041 chr1:40204384 PPIE 0.45 9.64 0.36 1.25e-20 Blood protein levels; BRCA cis rs2479724 0.935 rs2254936 chr6:41846569 A/G cg17623882 chr6:41773611 USP49 -0.38 -10.24 -0.38 6.9e-23 Menarche (age at onset); BRCA cis rs10751667 1.000 rs7927156 chr11:970607 A/G ch.11.42038R chr11:967971 AP2A2 0.5 15.01 0.51 7.22e-44 Alzheimer's disease (late onset); BRCA cis rs7777484 0.500 rs2533885 chr7:2835655 C/T cg19717773 chr7:2847554 GNA12 -0.49 -11.67 -0.42 1.16e-28 Height; BRCA cis rs113835537 0.529 rs17065 chr11:66277035 G/A cg24851651 chr11:66362959 CCS 0.5 8.73 0.33 2.25e-17 Airway imaging phenotypes; BRCA cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg18850127 chr7:39170497 POU6F2 0.56 12.08 0.43 2.05e-30 IgG glycosylation; BRCA cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg21918786 chr6:109611834 NA -0.48 -13.73 -0.48 8.68e-38 Reticulocyte fraction of red cells; BRCA cis rs6089584 0.566 rs6061963 chr20:60607480 C/G cg06108461 chr20:60628389 TAF4 -0.72 -15.13 -0.51 2.04e-44 Body mass index; BRCA cis rs798554 0.634 rs6978692 chr7:2857411 C/T cg19717773 chr7:2847554 GNA12 -0.43 -9.73 -0.36 5.89e-21 Height; BRCA cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg00531865 chr16:30841666 NA -0.58 -13.66 -0.48 1.77e-37 Multiple myeloma; BRCA cis rs4803468 1.000 rs6508977 chr19:41909346 A/G cg09537434 chr19:41945824 ATP5SL -0.98 -24.22 -0.69 2.02e-92 Height; BRCA cis rs2204008 0.837 rs10876019 chr12:37985477 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.09 0.56 3.13e-54 Bladder cancer; BRCA cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg17143192 chr8:8559678 CLDN23 0.54 10.27 0.38 5.39e-23 Obesity-related traits; BRCA cis rs3733585 0.699 rs7676733 chr4:9966956 G/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.21e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs965469 0.779 rs2236115 chr20:3296279 G/A cg25506879 chr20:3388711 C20orf194 -0.43 -8.71 -0.33 2.61e-17 IFN-related cytopenia; BRCA cis rs12618769 0.625 rs3769726 chr2:99105827 G/C cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.0 -0.34 2.59e-18 Menopause (age at onset); BRCA cis rs477692 0.673 rs556253 chr10:131355781 G/A cg05714579 chr10:131428358 MGMT 0.5 10.81 0.39 3.93e-25 Response to temozolomide; BRCA cis rs17023223 0.553 rs11484962 chr1:119725186 G/A cg05756136 chr1:119680316 WARS2 -0.42 -8.05 -0.3 3.98e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs2836974 0.897 rs35123057 chr21:40711689 C/T cg11890956 chr21:40555474 PSMG1 0.96 24.22 0.69 2.01e-92 Cognitive function; BRCA cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg18230493 chr5:56204884 C5orf35 0.85 16.14 0.54 2.01e-49 Initial pursuit acceleration; BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg00166722 chr3:10149974 C3orf24 0.64 11.32 0.41 3.47e-27 Alzheimer's disease; BRCA cis rs921968 0.541 rs12619347 chr2:219419935 T/C cg10223061 chr2:219282414 VIL1 0.3 8.45 0.32 2e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs6121246 0.647 rs6088855 chr20:30225792 C/T cg13852791 chr20:30311386 BCL2L1 0.76 13.92 0.48 1.12e-38 Mean corpuscular hemoglobin; BRCA cis rs11603020 0.950 rs28362950 chr11:57371918 G/A cg19752551 chr11:57585705 CTNND1 -0.42 -9.86 -0.36 1.84e-21 Blood protein levels; BRCA cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.51 8.64 0.32 4.61e-17 Lung function (FEV1/FVC); BRCA cis rs72772090 0.522 rs17398838 chr5:96003785 A/G cg17330273 chr5:96107758 CAST;ERAP1 -0.61 -8.32 -0.31 5.28e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.8 0.42 3.18e-29 Hip circumference adjusted for BMI; BRCA cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg18230493 chr5:56204884 C5orf35 -0.61 -13.01 -0.46 1.75e-34 Initial pursuit acceleration; BRCA cis rs8180040 0.966 rs11716763 chr3:47518266 C/T cg27129171 chr3:47204927 SETD2 -0.68 -16.05 -0.54 5.86e-49 Colorectal cancer; BRCA cis rs4665809 1.000 rs12469163 chr2:26283587 T/C cg26314531 chr2:26401878 FAM59B -0.66 -11.25 -0.41 6.63e-27 Gut microbiome composition (summer); BRCA cis rs4812048 1.000 rs6070692 chr20:57586374 A/G cg14073986 chr20:57617431 SLMO2 0.56 8.18 0.31 1.58e-15 Mean platelet volume; BRCA trans rs3749237 0.964 rs11714957 chr3:49776178 C/T cg21659725 chr3:3221576 CRBN 0.51 12.03 0.43 3.32e-30 Resting heart rate; BRCA cis rs875971 0.522 rs1617484 chr7:65463095 G/A cg18876405 chr7:65276391 NA 0.66 17.1 0.56 3.01e-54 Aortic root size; BRCA trans rs11098499 0.954 rs28685688 chr4:120420334 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.95 0.3 8.6e-15 Corneal astigmatism; BRCA cis rs17270561 0.636 rs2070642 chr6:25831212 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 9.45 0.35 6.15e-20 Iron status biomarkers; BRCA cis rs4285028 0.898 rs12491991 chr3:121706021 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.96 0.4 1e-25 Multiple sclerosis; BRCA cis rs6724607 1.000 rs11680758 chr2:191446268 T/G cg11845111 chr2:191398756 TMEM194B 0.4 9.29 0.35 2.32e-19 Pulse pressure; BRCA cis rs4820294 0.669 rs732857 chr22:38060850 C/T cg21798802 chr22:38057573 PDXP 0.32 9.01 0.34 2.39e-18 Fat distribution (HIV); BRCA cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg12893428 chr3:195717962 SDHAP1 0.33 8.1 0.31 2.86e-15 Pancreatic cancer; BRCA trans rs2562456 1.000 rs2359155 chr19:21671869 C/A cg25042112 chr7:64838748 ZNF92 0.41 7.99 0.3 6.28e-15 Pain; BRCA cis rs11690935 0.921 rs4668414 chr2:172704291 A/C cg13550731 chr2:172543902 DYNC1I2 -0.89 -27.4 -0.73 6.56e-110 Schizophrenia; BRCA cis rs4927850 1.000 rs7630875 chr3:195753766 A/G cg12923728 chr3:195709715 SDHAP1 -0.57 -12.16 -0.43 9.67e-31 Pancreatic cancer; BRCA cis rs10851411 0.542 rs10454692 chr15:42857055 T/C cg21293051 chr15:42870591 STARD9 0.52 8.8 0.33 1.29e-17 Glucose homeostasis traits; BRCA cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg05347473 chr6:146136440 FBXO30 -0.42 -8.51 -0.32 1.26e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs11146838 1 rs11146838 chr10:39149977 A/T cg23533926 chr12:111358616 MYL2 -0.48 -10.21 -0.37 8.87e-23 Breast cancer; BRCA cis rs3806843 0.735 rs2530240 chr5:140060547 T/C cg11822812 chr5:140052017 DND1 -0.3 -8.24 -0.31 9.59e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs6684514 0.922 rs12022657 chr1:156314147 A/G cg16558208 chr1:156270281 VHLL 0.37 8.34 0.31 4.59e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs798554 0.660 rs2644275 chr7:2854010 G/A cg09658497 chr7:2847517 GNA12 -0.41 -8.62 -0.32 5.42e-17 Height; BRCA cis rs17826219 0.568 rs11658027 chr17:29094882 A/G cg13385521 chr17:29058706 SUZ12P -0.66 -10.32 -0.38 3.45e-23 Body mass index; BRCA cis rs12348691 0.503 rs1867279 chr9:100616041 T/C cg13688889 chr9:100608707 NA -0.49 -9.9 -0.36 1.32e-21 Alopecia areata; BRCA cis rs9828933 0.938 rs2578011 chr3:64004819 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.62 -11.5 -0.41 6.09e-28 Type 2 diabetes; BRCA cis rs4819052 0.851 rs8134392 chr21:46663790 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.65 -14.27 -0.49 2.76e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs523522 0.962 rs10849754 chr12:120940418 A/C cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.17e-27 High light scatter reticulocyte count; BRCA cis rs651907 0.535 rs13094911 chr3:101519021 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.49 0.47 1.16e-36 Colorectal cancer; BRCA trans rs3942852 0.774 rs1039481 chr11:48182237 G/A cg15704280 chr7:45808275 SEPT13 -0.53 -10.27 -0.38 5.34e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs8067545 0.641 rs119672 chr17:19818601 A/G cg13482628 chr17:19912719 NA 0.46 11.51 0.41 5.28e-28 Schizophrenia; BRCA cis rs6963495 0.818 rs73190187 chr7:105164401 A/T cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs7666738 0.830 rs2098934 chr4:98992403 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.59e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10992471 0.603 rs10820974 chr9:95211876 T/C cg14631576 chr9:95140430 CENPP -0.35 -8.74 -0.33 2.07e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs11122272 0.735 rs2808601 chr1:231536571 A/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -11.63 -0.42 1.68e-28 Hemoglobin concentration; BRCA cis rs11583043 0.918 rs58029001 chr1:101393409 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.7 0.36 7.47e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs875971 1.000 rs9986696 chr7:65704576 C/A cg11764359 chr7:65958608 NA -0.79 -18.86 -0.6 2.17e-63 Aortic root size; BRCA cis rs10484885 0.877 rs17735389 chr6:90323139 G/T cg13799429 chr6:90582589 CASP8AP2 -0.63 -8.12 -0.31 2.35e-15 QRS interval (sulfonylurea treatment interaction); BRCA cis rs853679 0.517 rs9393901 chr6:28136797 A/G cg18032046 chr6:28092343 ZSCAN16 -0.52 -8.27 -0.31 7.83e-16 Depression; BRCA cis rs6815814 0.950 rs73236617 chr4:38793860 C/G cg06935464 chr4:38784597 TLR10 0.51 8.21 0.31 1.18e-15 Breast cancer; BRCA cis rs8058578 0.775 rs8046391 chr16:30836648 G/C cg00531865 chr16:30841666 NA -0.49 -11.5 -0.41 5.85e-28 Multiple myeloma; BRCA cis rs6088813 1.000 rs4911491 chr20:33947285 C/G cg14752227 chr20:34000481 UQCC -0.41 -8.78 -0.33 1.55e-17 Height; BRCA cis rs3772130 0.603 rs35489993 chr3:121411876 A/C cg01951420 chr3:121553821 IQCB1;EAF2 0.56 11.4 0.41 1.59e-27 Cognitive performance; BRCA cis rs7666738 0.830 rs11097582 chr4:98772201 G/A cg17366294 chr4:99064904 C4orf37 0.41 9.66 0.36 1.04e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs6087990 0.871 rs2424905 chr20:31352927 T/C cg13636640 chr20:31349939 DNMT3B 0.71 20.65 0.63 5.86e-73 Ulcerative colitis; BRCA trans rs1814175 0.529 rs1988417 chr11:49932430 A/G cg18944383 chr4:111397179 ENPEP 0.35 7.93 0.3 1.02e-14 Height; BRCA cis rs1707322 0.928 rs7527244 chr1:46368772 A/G cg03146154 chr1:46216737 IPP 0.45 10.09 0.37 2.49e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.671 rs2591961 chr5:56238597 A/G cg24549020 chr5:56110836 MAP3K1 -0.37 -7.87 -0.3 1.57e-14 Initial pursuit acceleration; BRCA cis rs2882667 0.898 rs13182437 chr5:138387149 T/C cg04439458 chr5:138467593 SIL1 -0.33 -8.84 -0.33 9.53e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs10927875 0.722 rs1763606 chr1:16338282 A/G cg06159980 chr1:16340746 HSPB7 -0.38 -7.9 -0.3 1.19e-14 Dilated cardiomyopathy; BRCA cis rs2505998 0.833 rs2505535 chr10:43593043 A/G cg15436174 chr10:43711423 RASGEF1A -0.43 -8.49 -0.32 1.46e-16 Hirschsprung disease; BRCA cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg06191203 chr2:152266755 RIF1 0.39 10.92 0.4 1.49e-25 Lung cancer; BRCA cis rs7903847 0.619 rs10882912 chr10:99138077 C/T cg20016023 chr10:99160130 RRP12 -0.27 -8.59 -0.32 6.67e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2404602 0.662 rs908817 chr15:76639191 G/A cg23625390 chr15:77176239 SCAPER -0.51 -12.05 -0.43 2.69e-30 Blood metabolite levels; BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg21248554 chr2:27665150 KRTCAP3 -0.34 -8.55 -0.32 9.02e-17 Menopause (age at onset); BRCA cis rs17092148 0.836 rs6059910 chr20:33142107 T/C cg16810054 chr20:33298113 TP53INP2 -0.46 -10.38 -0.38 1.97e-23 Neuroticism; BRCA cis rs312273 0.774 rs3794247 chr12:41359761 C/A cg17827154 chr12:41323612 CNTN1 -0.41 -10.71 -0.39 9.75e-25 Bipolar disorder; BRCA cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg25173405 chr17:45401733 C17orf57 0.55 11.57 0.42 3.11e-28 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9649213 0.555 rs7785612 chr7:97933867 T/A cg01877450 chr7:97915802 BRI3 -0.36 -8.17 -0.31 1.6e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg13010199 chr12:38710504 ALG10B 0.51 9.8 0.36 3.24e-21 Bladder cancer; BRCA cis rs7043114 0.507 rs7856204 chr9:95173814 G/C cg14631576 chr9:95140430 CENPP -0.31 -7.81 -0.3 2.3e-14 Height; BRCA cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg03146154 chr1:46216737 IPP 0.45 10.0 0.37 5.54e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504073 0.647 rs28685207 chr8:50003484 A/G cg00325661 chr8:49890786 NA 0.38 11.35 0.41 2.43e-27 Blood metabolite ratios; BRCA cis rs11785693 0.862 rs11778306 chr8:4988269 A/C cg26367366 chr8:4980734 NA 0.6 10.49 0.38 7.49e-24 Neuroticism (multi-trait analysis);Neuroticism; BRCA cis rs2250402 0.510 rs8031319 chr15:40323692 A/G cg10636054 chr15:40330586 SRP14 0.89 13.15 0.46 4.18e-35 Corneal curvature; BRCA cis rs473651 0.935 rs10170056 chr2:239339291 G/C cg18131467 chr2:239335373 ASB1 0.86 21.85 0.65 1.88e-79 Multiple system atrophy; BRCA cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg08219700 chr8:58056026 NA 0.56 9.15 0.34 7.49e-19 Developmental language disorder (linguistic errors); BRCA cis rs13046373 0.508 rs1507393 chr21:31992779 A/G cg14062083 chr21:31802829 KRTAP13-4 0.34 9.23 0.34 3.92e-19 HDL cholesterol; BRCA cis rs7605378 0.528 rs812760 chr2:200724372 C/T cg17644776 chr2:200775616 C2orf69 0.45 9.39 0.35 1.07e-19 Osteoporosis; BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg05863683 chr7:1912471 MAD1L1 0.4 8.38 0.31 3.27e-16 Bipolar disorder and schizophrenia; BRCA trans rs61931739 0.500 rs9795938 chr12:34587739 C/T cg26384229 chr12:38710491 ALG10B -0.61 -13.88 -0.48 1.7e-38 Morning vs. evening chronotype; BRCA cis rs10751667 0.643 rs7942693 chr11:957832 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.2 -0.54 1.11e-49 Alzheimer's disease (late onset); BRCA cis rs4853012 0.838 rs61521879 chr2:74346208 T/C cg01017244 chr2:74357527 NA 0.53 12.68 0.45 5.08e-33 Gestational age at birth (maternal effect); BRCA cis rs317689 0.513 rs529268 chr12:69687051 G/A cg14784868 chr12:69753453 YEATS4 0.48 11.22 0.41 8.97e-27 Response to diuretic therapy; BRCA cis rs6840360 0.615 rs12641441 chr4:152607623 A/G cg22705602 chr4:152727874 NA -0.37 -10.04 -0.37 4.13e-22 Intelligence (multi-trait analysis); BRCA trans rs7618501 1.000 rs6802890 chr3:49832261 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.52 16.52 0.55 2.62e-51 Intelligence (multi-trait analysis); BRCA cis rs9527 0.567 rs6584539 chr10:104879402 G/C cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA cis rs9388451 0.587 rs1739385 chr6:126099939 G/A cg05901451 chr6:126070800 HEY2 -0.54 -14.42 -0.5 5.18e-41 Brugada syndrome; BRCA cis rs4665809 0.549 rs13001722 chr2:26521530 T/C cg25036284 chr2:26402008 FAM59B 0.94 14.81 0.51 7.39e-43 Gut microbiome composition (summer); BRCA cis rs4727027 0.933 rs12667123 chr7:148850621 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.91 0.4 1.61e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4819052 0.851 rs7275870 chr21:46671214 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.64 0.36 1.22e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.667 rs2250773 chr21:45087786 T/C cg04455712 chr21:45112962 RRP1B 0.47 12.95 0.46 3.25e-34 Mean corpuscular volume; BRCA trans rs11098499 0.865 rs11722183 chr4:120280597 A/C cg25214090 chr10:38739885 LOC399744 0.53 12.1 0.43 1.8e-30 Corneal astigmatism; BRCA cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg20891283 chr12:69753455 YEATS4 0.73 21.68 0.65 1.5e-78 Blood protein levels; BRCA cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg13010199 chr12:38710504 ALG10B -0.4 -8.54 -0.32 9.5e-17 Bladder cancer; BRCA cis rs798766 1.000 rs1665366 chr4:1728381 A/G cg10756475 chr4:1757242 NA -0.39 -8.97 -0.33 3.3e-18 Bladder cancer;Urinary bladder cancer; BRCA cis rs192264 0.614 rs7186848 chr16:65987204 A/G cg03491821 chr16:65994309 NA 0.32 7.89 0.3 1.28e-14 Subjective well-being; BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.74 -12.89 -0.45 6.04e-34 Gut microbiome composition (summer); BRCA cis rs769267 0.965 rs4808200 chr19:19554803 C/T cg03709012 chr19:19516395 GATAD2A 0.78 18.24 0.59 3.93e-60 Tonsillectomy; BRCA cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 1.000 rs778685 chr7:65836176 G/T cg18876405 chr7:65276391 NA 0.55 13.29 0.47 9.4e-36 Aortic root size; BRCA cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg27478167 chr7:817139 HEATR2 -0.42 -8.98 -0.33 3.03e-18 Cerebrospinal P-tau181p levels; BRCA cis rs7246967 0.673 rs937078 chr19:22811667 G/A cg23217946 chr19:22817039 ZNF492 0.47 8.43 0.32 2.22e-16 Bronchopulmonary dysplasia; BRCA cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs11112613 0.713 rs4015312 chr12:105948757 A/G cg03607813 chr12:105948248 NA 0.6 9.46 0.35 5.86e-20 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg23285459 chr7:2802560 GNA12 0.32 8.15 0.31 1.94e-15 Height; BRCA cis rs4363385 0.818 rs4576617 chr1:152985729 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.91 -0.33 5.26e-18 Inflammatory skin disease; BRCA cis rs35110281 0.807 rs1598206 chr21:45058776 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.88 0.4 2.13e-25 Mean corpuscular volume; BRCA cis rs26868 0.742 rs26848 chr16:2263516 A/G cg02248941 chr16:2239361 CASKIN1 0.48 11.21 0.41 9.91e-27 Height; BRCA cis rs11585357 0.895 rs877552 chr1:17631236 C/T cg08277548 chr1:17600880 PADI3 -0.69 -11.79 -0.42 3.58e-29 Hair shape; BRCA cis rs72781680 0.898 rs72782137 chr2:24047805 C/T cg20701182 chr2:24300061 SF3B14 0.58 9.11 0.34 1.04e-18 Lymphocyte counts; BRCA cis rs4268898 0.722 rs4665253 chr2:24382546 G/A cg06627628 chr2:24431161 ITSN2 0.44 9.1 0.34 1.18e-18 Asthma; BRCA cis rs7255436 0.965 rs7351098 chr19:8451671 G/C cg10174797 chr19:8464628 RAB11B 0.35 9.01 0.34 2.4e-18 HDL cholesterol; BRCA cis rs1163251 0.902 rs511059 chr1:120217081 G/T cg19096424 chr1:120255104 PHGDH 0.44 9.68 0.36 9.06e-21 Blood metabolite levels; BRCA cis rs12413816 0.784 rs35537139 chr10:13768894 G/A cg16485048 chr10:13749193 FRMD4A 0.58 12.81 0.45 1.3e-33 Red cell distribution width; BRCA cis rs2404602 0.735 rs4886798 chr15:76673226 A/G cg23625390 chr15:77176239 SCAPER 0.53 12.59 0.45 1.22e-32 Blood metabolite levels; BRCA cis rs7618501 0.574 rs6765484 chr3:50041313 C/T cg24308560 chr3:49941425 MST1R 0.38 7.91 0.3 1.13e-14 Intelligence (multi-trait analysis); BRCA cis rs12310956 0.515 rs1872745 chr12:33985987 G/A cg06521331 chr12:34319734 NA -0.56 -10.84 -0.39 2.95e-25 Morning vs. evening chronotype; BRCA cis rs3806843 0.868 rs2563281 chr5:140131219 T/A cg11822812 chr5:140052017 DND1 -0.32 -8.69 -0.33 3.01e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs244731 0.959 rs4976677 chr5:176629546 G/A cg16006841 chr5:176797999 RGS14 -0.68 -10.84 -0.39 2.9e-25 Urate levels in lean individuals; BRCA cis rs873946 0.648 rs3750578 chr10:134563366 A/G cg26818010 chr10:134567672 INPP5A -0.79 -15.79 -0.53 1.13e-47 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4803468 1.000 rs284654 chr19:41928724 G/A cg09537434 chr19:41945824 ATP5SL -0.99 -23.35 -0.68 1.14e-87 Height; BRCA cis rs35306767 0.903 rs12249828 chr10:894838 C/T cg25019033 chr10:957182 NA -0.41 -7.93 -0.3 9.72e-15 Eosinophil percentage of granulocytes; BRCA cis rs10782582 0.593 rs11802717 chr1:76124648 C/T cg03433033 chr1:76189801 ACADM -0.47 -9.86 -0.36 1.94e-21 Daytime sleep phenotypes; BRCA cis rs514406 0.505 rs436363 chr1:53172163 T/C cg16325326 chr1:53192061 ZYG11B 0.86 25.56 0.71 7.97e-100 Monocyte count; BRCA cis rs4713118 0.513 rs149950 chr6:28033039 T/G cg10876282 chr6:28092338 ZSCAN16 0.4 7.91 0.3 1.17e-14 Parkinson's disease; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg18279126 chr7:2041391 MAD1L1 0.39 8.76 0.33 1.74e-17 Bipolar disorder and schizophrenia; BRCA trans rs6582630 0.502 rs2387603 chr12:38353389 A/C cg06521331 chr12:34319734 NA -0.44 -8.35 -0.31 4.37e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 14.94 0.51 1.61e-43 Hip circumference adjusted for BMI; BRCA cis rs6570726 0.791 rs383841 chr6:145888329 G/T cg23711669 chr6:146136114 FBXO30 -0.8 -19.42 -0.61 2.14e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs6964587 0.934 rs73226382 chr7:91692760 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 4.16e-15 Breast cancer; BRCA cis rs2710642 0.962 rs2058567 chr2:63091426 T/C cg17519650 chr2:63277830 OTX1 0.36 7.93 0.3 9.58e-15 LDL cholesterol levels;LDL cholesterol; BRCA cis rs9381040 0.655 rs7738684 chr6:41038552 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.85 -0.33 8.29e-18 Alzheimer's disease (late onset); BRCA cis rs4363385 0.620 rs4388644 chr1:152983674 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.78 -0.36 3.98e-21 Inflammatory skin disease; BRCA cis rs2370759 1.000 rs75984055 chr10:32591276 T/C cg01819863 chr10:32635814 EPC1 1.14 20.12 0.62 4.08e-70 Sexual dysfunction (female); BRCA cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg09035930 chr12:129282057 SLC15A4 0.57 17.35 0.57 1.48e-55 Systemic lupus erythematosus; BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg24642844 chr7:1081250 C7orf50 -0.88 -16.14 -0.54 2.03e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs765787 0.530 rs55771002 chr15:45541566 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.07 0.3 3.4e-15 Uric acid levels; BRCA cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg18230493 chr5:56204884 C5orf35 0.87 16.37 0.54 1.48e-50 Initial pursuit acceleration; BRCA cis rs250677 0.687 rs40523 chr5:148444186 A/T cg18129178 chr5:148520854 ABLIM3 0.58 11.94 0.43 8.41e-30 Breast cancer; BRCA cis rs3806843 0.568 rs2530232 chr5:140082878 A/G cg16179182 chr5:140090404 VTRNA1-1 0.45 10.52 0.38 5.34e-24 Depressive symptoms (multi-trait analysis); BRCA cis rs7772486 0.790 rs9390365 chr6:146235626 A/G cg05347473 chr6:146136440 FBXO30 -0.41 -8.06 -0.3 3.86e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2415984 0.622 rs10131871 chr14:46931700 A/G cg14871534 chr14:47121158 RPL10L 0.36 8.6 0.32 6.09e-17 Number of children ever born; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.71 15.02 0.51 7.21e-44 Lymphocyte counts; BRCA cis rs4819052 0.851 rs4819042 chr21:46660072 A/G cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs56104184 0.775 rs56349331 chr19:49403009 T/A cg21252483 chr19:49399788 TULP2 -0.51 -10.75 -0.39 7e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs12142240 0.698 rs68083747 chr1:46807416 T/G cg00530320 chr1:46809349 NSUN4 0.48 9.6 0.35 1.83e-20 Menopause (age at onset); BRCA cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.54 0.38 4.55e-24 IgG glycosylation; BRCA cis rs4975616 0.804 rs462608 chr5:1336626 T/A cg06550200 chr5:1325588 CLPTM1L -0.64 -13.56 -0.47 5.61e-37 Lung cancer; BRCA cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs7586879 0.828 rs1968482 chr2:25086858 T/C cg04586622 chr2:25135609 ADCY3 0.39 9.19 0.34 5.48e-19 Body mass index; BRCA cis rs6089584 1.000 rs6089585 chr20:60564395 G/A cg12751644 chr20:60527061 NA -0.33 -7.88 -0.3 1.4e-14 Body mass index; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg05793240 chr7:2802953 GNA12 -0.34 -8.77 -0.33 1.67e-17 Height; BRCA cis rs2549003 1.000 rs2549003 chr5:131829297 A/G cg02551604 chr5:131831745 NA -0.4 -15.26 -0.52 4.76e-45 Asthma (sex interaction); BRCA cis rs9733 0.536 rs10888385 chr1:150574302 T/C cg13175981 chr1:150552382 MCL1 0.49 10.93 0.4 1.31e-25 Tonsillectomy; BRCA cis rs3858526 0.523 rs10769287 chr11:5884845 T/C cg05234568 chr11:5960015 NA -0.44 -9.49 -0.35 4.45e-20 DNA methylation (variation); BRCA cis rs12666575 0.504 rs10226475 chr7:2226162 A/G cg02951883 chr7:2050386 MAD1L1 -0.41 -9.55 -0.35 2.83e-20 Schizophrenia; BRCA cis rs1044826 0.642 rs186103 chr3:139211942 C/A cg00490450 chr3:139108681 COPB2 0.45 8.96 0.33 3.66e-18 Obesity-related traits; BRCA cis rs4665809 0.590 rs62128455 chr2:26466530 G/A cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs2832191 0.632 rs1984011 chr21:30337831 T/A cg08807101 chr21:30365312 RNF160 -0.76 -19.95 -0.62 3.21e-69 Dental caries; BRCA cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg16680214 chr1:154839983 KCNN3 -0.45 -12.42 -0.44 6.9e-32 Prostate cancer; BRCA cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg00745463 chr17:30367425 LRRC37B -0.61 -9.51 -0.35 3.69e-20 Hip circumference adjusted for BMI; BRCA cis rs6089584 0.888 rs6089624 chr20:60619907 C/G cg06108461 chr20:60628389 TAF4 -0.98 -22.18 -0.66 2.8e-81 Body mass index; BRCA cis rs2832077 0.527 rs2250141 chr21:30241984 A/T cg24692254 chr21:30365293 RNF160 0.5 11.25 0.41 6.76e-27 Cognitive test performance; BRCA cis rs1577917 0.740 rs7775864 chr6:86247759 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 12.93 0.46 4e-34 Response to antipsychotic treatment; BRCA cis rs1153858 0.945 rs7182300 chr15:45634928 G/A cg21132104 chr15:45694354 SPATA5L1 0.71 15.82 0.53 8.38e-48 Homoarginine levels; BRCA cis rs7772486 0.790 rs2254288 chr6:146204470 G/A cg23711669 chr6:146136114 FBXO30 0.67 15.72 0.53 2.52e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs7208859 0.614 rs28758251 chr17:29223312 A/T cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs3960554 0.867 rs11489553 chr7:75843062 G/A cg19862616 chr7:65841803 NCRNA00174 0.6 11.68 0.42 1.08e-28 Eotaxin levels; BRCA trans rs931812 0.895 rs4236763 chr8:101913022 G/A cg20993868 chr7:22813445 NA 0.52 14.22 0.49 4.5e-40 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs6598955 0.671 rs10902727 chr1:26597781 C/T cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs10170846 0.800 rs10194743 chr2:223518151 A/G cg25565276 chr2:223520875 FARSB 0.48 13.04 0.46 1.2e-34 Schizophrenia (inflammation and infection response interaction); BRCA trans rs2736345 0.516 rs7844858 chr8:11392659 T/A cg06636001 chr8:8085503 FLJ10661 0.41 8.4 0.32 2.89e-16 Sjögren's syndrome;Systemic lupus erythematosus; BRCA cis rs6912958 0.781 rs9450752 chr6:88300013 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.44 -0.32 2.08e-16 Monocyte percentage of white cells; BRCA cis rs9858542 1.000 rs1131095 chr3:49714225 T/C cg03060546 chr3:49711283 APEH -0.59 -11.93 -0.43 9.23e-30 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1874326 0.504 rs7793703 chr7:138113421 T/G cg18008034 chr7:138118925 NA -0.44 -9.04 -0.34 1.78e-18 Quantitative traits; BRCA cis rs1552244 0.935 rs41520445 chr3:10153141 A/C cg02579736 chr3:10068473 FANCD2;CIDECP -0.91 -18.14 -0.58 1.23e-59 Alzheimer's disease; BRCA trans rs61931739 0.500 rs11836198 chr12:34552782 T/C cg13010199 chr12:38710504 ALG10B 0.43 9.22 0.34 4.33e-19 Morning vs. evening chronotype; BRCA cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg01874867 chr7:94954059 PON1 -0.39 -7.83 -0.3 2.03e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs736801 0.759 rs11741255 chr5:131811182 G/A cg07395648 chr5:131743802 NA -0.38 -8.49 -0.32 1.46e-16 Breast cancer;Mosquito bite size; BRCA cis rs2742234 0.541 rs10793422 chr10:43703874 G/A cg15436174 chr10:43711423 RASGEF1A 0.56 11.34 0.41 2.82e-27 Hirschsprung disease; BRCA cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg00074818 chr8:8560427 CLDN23 0.37 8.25 0.31 9.1e-16 Obesity-related traits; BRCA cis rs9287719 0.967 rs728282 chr2:10750303 A/G cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs11051970 0.879 rs2728669 chr12:32590651 C/T cg02745156 chr12:32552066 NA 0.27 8.64 0.32 4.45e-17 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7666738 0.830 rs2865949 chr4:99039967 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.88 0.4 2.02e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1215050 0.791 rs13114823 chr4:98671119 G/A cg05340658 chr4:99064831 C4orf37 -0.44 -9.88 -0.36 1.57e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10465746 0.714 rs12730621 chr1:84433745 C/G cg10977910 chr1:84465055 TTLL7 0.57 11.92 0.43 1.01e-29 Obesity-related traits; BRCA cis rs1832871 0.672 rs9456289 chr6:158740347 G/A cg07165851 chr6:158734300 TULP4 0.63 12.61 0.45 9.95e-33 Height; BRCA cis rs34293785 0.565 rs59710023 chr1:66137193 T/C cg04111102 chr1:66153794 NA 0.36 8.71 0.33 2.67e-17 Neutrophil percentage of white cells;Granulocyte percentage of myeloid white cells;Sum neutrophil eosinophil counts;Monocyte percentage of white cells;Sum basophil neutrophil counts;Neutrophil count;White blood cell count; BRCA cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg06453172 chr10:134556979 INPP5A -0.49 -10.67 -0.39 1.47e-24 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7613875 0.600 rs7061 chr3:50114515 C/T cg05623727 chr3:50126028 RBM5 -0.51 -12.14 -0.43 1.2e-30 Body mass index; BRCA cis rs6912958 0.781 rs6454632 chr6:88231824 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.32 -8.73 -0.33 2.19e-17 Monocyte percentage of white cells; BRCA cis rs1843834 0.931 rs10170573 chr2:225552916 A/G cg22455342 chr2:225449267 CUL3 0.37 8.71 0.33 2.57e-17 IgE levels in asthmatics (D.p. specific); BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.59 -12.34 -0.44 1.56e-31 Lymphocyte counts; BRCA cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs4665809 1.000 rs4665811 chr2:26260017 A/G cg08470875 chr2:26401718 FAM59B -0.51 -8.21 -0.31 1.19e-15 Gut microbiome composition (summer); BRCA cis rs12586317 0.620 rs28870452 chr14:35536878 C/A cg05294307 chr14:35346193 BAZ1A -0.6 -10.39 -0.38 1.88e-23 Psoriasis; BRCA cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.7 0.36 7.73e-21 Bipolar disorder; BRCA cis rs7666738 0.830 rs2903154 chr4:99048151 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.94 0.3 9.23e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6580649 1.000 rs3825404 chr12:48399931 A/G cg24011408 chr12:48396354 COL2A1 0.52 8.95 0.33 3.72e-18 Lung cancer; BRCA cis rs9487051 0.803 rs11153161 chr6:109541774 A/G cg21918786 chr6:109611834 NA -0.35 -8.59 -0.32 6.46e-17 Reticulocyte fraction of red cells; BRCA trans rs1005277 0.579 rs176880 chr10:38401417 C/G cg17830980 chr10:43048298 ZNF37B 0.57 14.06 0.49 2.5e-39 Extrinsic epigenetic age acceleration; BRCA cis rs4919087 0.884 rs4917762 chr10:98976471 G/T cg25902810 chr10:99078978 FRAT1 0.4 8.5 0.32 1.31e-16 Monocyte count; BRCA cis rs796364 1.000 rs281788 chr2:200783705 A/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.92 0.46 4.48e-34 Schizophrenia; BRCA cis rs13191362 1.000 rs35449999 chr6:163023465 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.6 0.32 6.26e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1552244 0.882 rs13099507 chr3:10031603 G/A cg00166722 chr3:10149974 C3orf24 0.58 10.03 0.37 4.48e-22 Alzheimer's disease; BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg19723775 chr5:179050963 HNRNPH1 0.37 8.71 0.33 2.67e-17 Lung cancer; BRCA trans rs66887589 0.592 rs28580295 chr4:120278873 C/T cg25214090 chr10:38739885 LOC399744 0.37 8.78 0.33 1.52e-17 Diastolic blood pressure; BRCA cis rs7772486 0.790 rs6917135 chr6:146152426 T/C cg13319975 chr6:146136371 FBXO30 -0.34 -8.03 -0.3 4.84e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.872 rs113119264 chr7:1080564 G/A cg23708337 chr7:1209742 NA 0.63 8.86 0.33 8.16e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4660306 0.961 rs945179 chr1:45992460 A/G cg24296786 chr1:45957014 TESK2 -0.44 -8.86 -0.33 7.94e-18 Homocysteine levels; BRCA cis rs4953076 0.573 rs67537903 chr2:44422111 G/A cg04920474 chr2:44395004 PPM1B 0.51 10.13 0.37 1.81e-22 Height; BRCA cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -8.09 -0.3 2.94e-15 Developmental language disorder (linguistic errors); BRCA cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg16850897 chr7:100343110 ZAN 0.45 9.83 0.36 2.48e-21 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7772486 0.714 rs1883365 chr6:146076749 C/T cg13319975 chr6:146136371 FBXO30 0.34 8.0 0.3 5.98e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4900538 0.855 rs1190537 chr14:102887816 C/T cg18135206 chr14:102964638 TECPR2 -0.91 -21.41 -0.65 4.58e-77 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7264396 0.563 rs2425100 chr20:34310115 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Total cholesterol levels; BRCA cis rs17092148 0.887 rs4911430 chr20:33145404 C/G cg16810054 chr20:33298113 TP53INP2 -0.45 -10.09 -0.37 2.64e-22 Neuroticism; BRCA cis rs701145 0.556 rs355758 chr3:154007682 C/G cg12800244 chr3:153838788 SGEF -0.42 -8.37 -0.31 3.62e-16 Coronary artery disease; BRCA cis rs965469 1.000 rs6051713 chr20:3265779 C/T cg25506879 chr20:3388711 C20orf194 0.51 10.32 0.38 3.32e-23 IFN-related cytopenia; BRCA cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg19274703 chr22:41806451 NA 0.34 7.9 0.3 1.23e-14 Vitiligo; BRCA trans rs4650994 0.525 rs2811295 chr1:178551267 C/T cg05059571 chr16:84539110 KIAA1609 0.54 12.45 0.44 5.11e-32 HDL cholesterol levels;HDL cholesterol; BRCA trans rs2204008 0.687 rs1733404 chr12:38123395 G/T cg06521331 chr12:34319734 NA 0.53 10.15 0.37 1.54e-22 Bladder cancer; BRCA cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7618915 0.547 rs4687548 chr3:52666650 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.12 0.4 2.24e-26 Bipolar disorder; BRCA cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.59 0.32 6.78e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4930561 0.765 rs7931502 chr11:67959607 A/C cg16338278 chr11:67432957 ALDH3B2 -0.41 -8.41 -0.32 2.75e-16 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA trans rs7824557 0.701 rs4568582 chr8:11160495 A/T cg06636001 chr8:8085503 FLJ10661 0.55 10.4 0.38 1.61e-23 Retinal vascular caliber; BRCA cis rs6063312 1.000 rs6063313 chr20:47343532 G/A cg18078177 chr20:47281410 PREX1 0.65 11.26 0.41 5.84e-27 Tonometry; BRCA cis rs6582630 0.555 rs10748382 chr12:38504529 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.72 0.39 9.15e-25 Drug-induced liver injury (flucloxacillin); BRCA cis rs4925386 0.840 rs6143036 chr20:60921721 C/A cg06026331 chr20:60912101 LAMA5 0.63 12.51 0.44 2.91e-32 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs12611088 0.515 rs2599454 chr19:44025201 T/C cg15012607 chr19:44012195 ETHE1 -0.35 -9.02 -0.34 2.09e-18 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs1555322 0.530 rs2297789 chr20:33867248 A/T cg03689076 chr20:33865952 NA 0.46 8.47 0.32 1.73e-16 Attention deficit hyperactivity disorder; BRCA cis rs13191362 0.935 rs7769048 chr6:163010040 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs3733585 0.648 rs7378305 chr4:9954893 C/T cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 9.22e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs7786808 0.741 rs11769149 chr7:158227127 A/G cg02030672 chr11:45687055 CHST1 -0.37 -7.91 -0.3 1.1e-14 Obesity-related traits; BRCA trans rs6598955 0.671 rs7417505 chr1:26575523 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs2836950 0.501 rs2836983 chr21:40689336 G/A cg17971929 chr21:40555470 PSMG1 -0.48 -10.57 -0.39 3.68e-24 Menarche (age at onset); BRCA cis rs5167 0.504 rs4803779 chr19:45456497 T/C cg20090143 chr19:45452003 APOC2 0.27 8.04 0.3 4.44e-15 Blood protein levels; BRCA cis rs7666738 0.830 rs4345191 chr4:98945408 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs4319547 0.586 rs7956480 chr12:122817507 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.39 -0.35 1e-19 Body mass index; BRCA trans rs7819412 0.594 rs17724226 chr8:10968926 C/T cg06636001 chr8:8085503 FLJ10661 -0.51 -10.61 -0.39 2.36e-24 Triglycerides; BRCA cis rs796364 0.806 rs79053279 chr2:201057443 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.63 -9.09 -0.34 1.2e-18 Schizophrenia; BRCA trans rs61931739 0.500 rs12832312 chr12:34031199 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.43 0.5 4.38e-41 Morning vs. evening chronotype; BRCA cis rs7586673 1.000 rs7586673 chr2:161923520 C/A cg22496339 chr2:162101262 NA 0.4 8.1 0.31 2.83e-15 Intelligence (multi-trait analysis); BRCA cis rs10227331 1.000 rs10227331 chr7:157294938 A/T cg04156418 chr7:157293606 NA 0.37 10.97 0.4 9.05e-26 Inattentive symptoms; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg09436375 chr6:42928200 GNMT -0.3 -11.12 -0.4 2.14e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7524258 0.868 rs4908607 chr1:7269323 A/G cg07173049 chr1:7289937 CAMTA1 0.45 11.14 0.4 1.91e-26 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg04317338 chr11:64019027 PLCB3 0.56 9.56 0.35 2.43e-20 Mean platelet volume; BRCA cis rs2731664 0.792 rs335468 chr5:176892349 A/G cg23176889 chr5:176863531 GRK6 0.59 15.55 0.52 1.8e-46 Intelligence (multi-trait analysis); BRCA cis rs11792861 0.926 rs72607170 chr9:111836941 G/A cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.16 0.31 1.74e-15 Menarche (age at onset); BRCA cis rs67340775 0.541 rs200966 chr6:27862152 T/C cg26587870 chr6:27730563 NA -0.43 -7.86 -0.3 1.64e-14 Lung cancer in ever smokers; BRCA cis rs7666738 0.753 rs7659724 chr4:98944063 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs6037105 chr20:25374199 C/A cg08601574 chr20:25228251 PYGB -0.34 -8.25 -0.31 9.18e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6460942 0.778 rs17444259 chr7:12462428 C/T cg06484146 chr7:12443880 VWDE -0.62 -9.86 -0.36 1.98e-21 Coronary artery disease; BRCA cis rs7927771 0.832 rs4752994 chr11:47411065 A/T cg20307385 chr11:47447363 PSMC3 0.4 8.44 0.32 2.1e-16 Subjective well-being; BRCA cis rs12477438 0.501 rs11123770 chr2:99825102 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.71 19.47 0.61 1.28e-66 Chronic sinus infection; BRCA cis rs12497850 0.864 rs7431857 chr3:48900347 G/A cg06212747 chr3:49208901 KLHDC8B 0.47 9.56 0.35 2.4e-20 Parkinson's disease; BRCA cis rs7666738 0.791 rs13128640 chr4:99003918 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.698 rs72886907 chr1:46814265 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 9.31e-21 Menopause (age at onset); BRCA trans rs3960554 0.674 rs113848658 chr7:75791858 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 11.94 0.43 8.64e-30 Eotaxin levels; BRCA cis rs9837602 0.507 rs793453 chr3:99529095 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.65 -14.76 -0.5 1.2e-42 Breast cancer; BRCA cis rs68170813 0.559 rs76534758 chr7:106963262 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.85 -0.33 8.5e-18 Coronary artery disease; BRCA cis rs12477438 0.520 rs6756650 chr2:99801800 T/C cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs9790314 0.747 rs1610158 chr3:160815050 A/G cg03342759 chr3:160939853 NMD3 0.5 10.1 0.37 2.34e-22 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs1834647 chr4:98882915 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.89 0.36 1.44e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg06640241 chr16:89574553 SPG7 -0.75 -18.4 -0.59 5.61e-61 Multiple myeloma (IgH translocation); BRCA cis rs9527 0.662 rs743575 chr10:104594906 T/G cg04362960 chr10:104952993 NT5C2 0.46 9.95 0.37 8.89e-22 Arsenic metabolism; BRCA cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg07636037 chr3:49044803 WDR6 0.58 9.29 0.35 2.3e-19 Menarche (age at onset); BRCA cis rs6842047 1.000 rs72647308 chr4:187135129 G/A cg09526685 chr4:187126073 CYP4V2 -1.0 -11.98 -0.43 5.42e-30 Blood protein levels; BRCA cis rs9486719 1.000 rs3798289 chr6:97023632 T/C cg06623918 chr6:96969491 KIAA0776 -0.77 -13.77 -0.48 5.7800000000000005e-38 Migraine;Coronary artery disease; BRCA cis rs10504229 0.683 rs2005392 chr8:58106896 T/C cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs4689388 0.791 rs1046317 chr4:6304242 T/C cg00701064 chr4:6280414 WFS1 0.66 14.53 0.5 1.54e-41 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs11098499 0.708 rs1546506 chr4:120241240 T/C cg25214090 chr10:38739885 LOC399744 0.45 10.41 0.38 1.48e-23 Corneal astigmatism; BRCA cis rs763121 0.853 rs2235230 chr22:39124467 A/G cg06544989 chr22:39130855 UNC84B -0.38 -8.4 -0.32 3e-16 Menopause (age at onset); BRCA cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg24812749 chr6:127587940 RNF146 0.88 20.56 0.63 1.81e-72 Breast cancer; BRCA cis rs1371614 0.655 rs7579579 chr2:27151842 C/T cg00617064 chr2:27272375 NA 0.31 7.9 0.3 1.22e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs4588572 0.645 rs10059940 chr5:77680873 T/C cg11547950 chr5:77652471 NA 0.44 7.84 0.3 1.95e-14 Triglycerides; BRCA cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.78 -0.33 1.48e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs72720396 0.789 rs12022460 chr1:91202257 A/G cg13456504 chr1:91191583 NA -0.53 -9.97 -0.37 7.35e-22 Morning vs. evening chronotype;Chronotype; BRCA cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.33 0.31 4.93e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7092929 0.882 rs535539 chr10:3574757 T/C cg14308648 chr10:3568949 NA 0.46 8.17 0.31 1.7e-15 Coronary artery calcification; BRCA cis rs12477438 0.798 rs10167015 chr2:99570707 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -14.17 -0.49 7.89e-40 Chronic sinus infection; BRCA cis rs13064411 0.660 rs11916690 chr3:113012343 A/C cg18753928 chr3:113234510 CCDC52 -0.42 -7.84 -0.3 1.94e-14 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg02592271 chr2:27665507 KRTCAP3 -0.32 -8.16 -0.31 1.75e-15 Total body bone mineral density; BRCA cis rs1712517 0.771 rs11191645 chr10:105059308 G/T cg05636881 chr10:105038444 INA 0.35 7.87 0.3 1.52e-14 Migraine; BRCA cis rs832540 0.669 rs832538 chr5:56200016 C/T cg24549020 chr5:56110836 MAP3K1 0.37 8.06 0.3 3.64e-15 Coronary artery disease; BRCA cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg18404041 chr3:52824283 ITIH1 -0.28 -8.21 -0.31 1.19e-15 Electroencephalogram traits; BRCA cis rs9487051 0.872 rs1111865 chr6:109610863 A/G cg21918786 chr6:109611834 NA 0.48 13.64 0.47 2.3e-37 Reticulocyte fraction of red cells; BRCA cis rs6831352 0.959 rs4699710 chr4:100051819 C/T cg13256891 chr4:100009986 ADH5 0.47 9.06 0.34 1.52e-18 Alcohol dependence; BRCA cis rs2070488 0.775 rs6599207 chr3:38554901 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.6 -0.53 1.01e-46 Electrocardiographic conduction measures; BRCA cis rs140364877 1 rs140364877 chr7:1885178 C/T cg04267008 chr7:1944627 MAD1L1 -0.56 -11.94 -0.43 8.21e-30 Autism spectrum disorder or schizophrenia; BRCA cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg18713687 chr3:195489789 MUC4 0.55 8.59 0.32 6.62e-17 Lung disease severity in cystic fibrosis; BRCA cis rs250677 0.687 rs36048 chr5:148441713 G/C cg18129178 chr5:148520854 ABLIM3 -0.58 -11.65 -0.42 1.44e-28 Breast cancer; BRCA cis rs919433 0.713 rs10172961 chr2:198446859 T/C cg00792783 chr2:198669748 PLCL1 0.34 7.9 0.3 1.25e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg10224037 chr5:178157518 ZNF354A 0.73 15.45 0.52 5.33e-46 Neutrophil percentage of white cells; BRCA cis rs9486719 0.948 rs12203657 chr6:96883285 G/A cg06623918 chr6:96969491 KIAA0776 -0.73 -12.97 -0.46 2.56e-34 Migraine;Coronary artery disease; BRCA trans rs61931739 0.635 rs10772122 chr12:33964674 A/C cg26384229 chr12:38710491 ALG10B 0.39 8.88 0.33 6.71e-18 Morning vs. evening chronotype; BRCA cis rs2602836 0.830 rs2602874 chr4:100039396 A/T cg13256891 chr4:100009986 ADH5 0.53 12.16 0.43 9.14e-31 HDL cholesterol;HDL cholesterol levels; BRCA cis rs9649213 0.593 rs7795176 chr7:97978287 A/C cg21770322 chr7:97807741 LMTK2 0.44 11.53 0.41 4.62e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs11955398 0.678 rs1824120 chr5:59997929 G/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.42e-19 Intelligence (multi-trait analysis); BRCA cis rs7707921 0.881 rs324910 chr5:81400264 A/C cg15871215 chr5:81402204 ATG10 -0.38 -8.09 -0.3 3.09e-15 Breast cancer; BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg00149659 chr3:10157352 C3orf10 0.65 10.1 0.37 2.47e-22 Alzheimer's disease; BRCA cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg18132916 chr6:79620363 NA 0.46 10.37 0.38 2.11e-23 Intelligence (multi-trait analysis); BRCA cis rs6460942 0.915 rs62448593 chr7:12436845 G/C cg10578991 chr7:12443926 VWDE -0.55 -8.04 -0.3 4.22e-15 Coronary artery disease; BRCA cis rs704795 0.805 rs1728926 chr2:27612937 A/G cg21747090 chr2:27597821 SNX17 -0.45 -9.65 -0.36 1.2e-20 Menopause (age at onset); BRCA cis rs6546550 0.935 rs6747542 chr2:70106832 T/C cg02498382 chr2:70120550 SNRNP27 -0.44 -9.5 -0.35 4.09e-20 Prevalent atrial fibrillation; BRCA cis rs2066819 1.000 rs871130 chr12:56648777 A/G cg26714650 chr12:56694279 CS 1.05 14.03 0.49 3.71e-39 Psoriasis vulgaris; BRCA cis rs9649213 0.593 rs7807455 chr7:97957622 C/A cg24562669 chr7:97807699 LMTK2 0.47 12.45 0.44 5.09e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg26384229 chr12:38710491 ALG10B -0.62 -16.28 -0.54 4.3e-50 Heart rate; BRCA cis rs933688 0.536 rs332537 chr5:90794973 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 -0.68 -11.83 -0.42 2.36e-29 Smoking behavior; BRCA cis rs7246657 0.943 rs9676967 chr19:37928089 G/C cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA cis rs912057 0.526 rs201061 chr6:6730512 C/T cg06612196 chr6:6737390 NA -0.54 -13.44 -0.47 2e-36 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs7833790 0.632 rs6473308 chr8:82707708 G/A cg17211192 chr8:82754475 SNX16 -0.5 -11.16 -0.4 1.51e-26 Diastolic blood pressure; BRCA cis rs701145 0.938 rs701147 chr3:154048295 C/T cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs7555523 0.779 rs6662839 chr1:165722646 T/G cg24409356 chr1:165738333 TMCO1 0.51 8.25 0.31 9.16e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA trans rs11039798 0.620 rs10838833 chr11:48238880 C/T cg15704280 chr7:45808275 SEPT13 0.54 8.09 0.3 3.03e-15 Axial length; BRCA cis rs4409675 0.527 rs12067053 chr1:28227122 T/G cg23691781 chr1:28212827 C1orf38 0.32 10.91 0.4 1.51e-25 Corneal astigmatism; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg03923535 chr7:1197113 ZFAND2A 0.47 9.55 0.35 2.7e-20 Longevity;Endometriosis; BRCA cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg03808351 chr9:123631620 PHF19 0.39 7.81 0.3 2.3e-14 Rheumatoid arthritis; BRCA cis rs7737355 0.947 rs6596007 chr5:130588550 A/G cg06307176 chr5:131281290 NA -0.44 -8.58 -0.32 7.31e-17 Life satisfaction; BRCA cis rs9837602 1.000 rs13323143 chr3:99811553 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.25e-26 Breast cancer; BRCA trans rs7824557 0.806 rs34171564 chr8:11095346 C/A cg06636001 chr8:8085503 FLJ10661 -0.48 -9.5 -0.35 4.26e-20 Retinal vascular caliber; BRCA cis rs739401 0.572 rs389285 chr11:3062673 G/A cg25174290 chr11:3078921 CARS 0.44 12.84 0.45 9.5e-34 Longevity; BRCA cis rs1580019 0.883 rs6945294 chr7:32472099 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.87 19.3 0.61 9.47e-66 Cognitive ability; BRCA trans rs2727020 0.664 rs4929893 chr11:49196332 C/T cg15704280 chr7:45808275 SEPT13 -0.8 -19.07 -0.6 1.55e-64 Coronary artery disease; BRCA cis rs812925 0.553 rs1177307 chr2:61387388 T/C cg15711740 chr2:61764176 XPO1 -0.32 -7.98 -0.3 6.66e-15 Immature fraction of reticulocytes; BRCA cis rs10751667 0.600 rs10902266 chr11:1005697 G/T ch.11.42038R chr11:967971 AP2A2 0.47 14.4 0.49 6.56e-41 Alzheimer's disease (late onset); BRCA cis rs875971 0.862 rs10240949 chr7:65804417 A/G cg18876405 chr7:65276391 NA -0.51 -11.59 -0.42 2.49e-28 Aortic root size; BRCA cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.87 0.36 1.84e-21 Aortic root size; BRCA cis rs2180341 0.961 rs3798857 chr6:127659473 A/T cg27446573 chr6:127587934 RNF146 0.89 21.1 0.64 2.1e-75 Breast cancer; BRCA cis rs6964587 0.692 rs4727268 chr7:91840724 T/C cg17063962 chr7:91808500 NA 0.57 13.11 0.46 6.29e-35 Breast cancer; BRCA cis rs10871290 0.881 rs7498574 chr16:74472661 A/G cg01733217 chr16:74700730 RFWD3 -0.53 -12.42 -0.44 7.29e-32 Breast cancer; BRCA cis rs2882667 0.690 rs3749664 chr5:138271421 T/C cg04439458 chr5:138467593 SIL1 -0.32 -8.08 -0.3 3.13e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1153858 1.000 rs7171577 chr15:45627979 G/A cg21132104 chr15:45694354 SPATA5L1 0.71 15.37 0.52 1.32e-45 Homoarginine levels; BRCA cis rs1018836 0.923 rs7007102 chr8:91629730 T/A cg16814680 chr8:91681699 NA -0.6 -12.86 -0.45 8.05e-34 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs9291683 0.507 rs6845554 chr4:10013173 T/G cg02734326 chr4:10020555 SLC2A9 0.36 7.88 0.3 1.37e-14 Bone mineral density; BRCA cis rs1153858 1.000 rs1554521 chr15:45664189 A/T cg14582100 chr15:45693742 SPATA5L1 -0.36 -11.77 -0.42 4.6e-29 Homoarginine levels; BRCA cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg13010199 chr12:38710504 ALG10B 0.5 9.96 0.37 8.03e-22 Bladder cancer; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg17158414 chr2:27665306 KRTCAP3 -0.34 -8.77 -0.33 1.61e-17 Total body bone mineral density; BRCA cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg20203395 chr5:56204925 C5orf35 0.4 8.69 0.32 3.12e-17 Coronary artery disease; BRCA cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg21856205 chr7:94953877 PON1 -0.37 -7.97 -0.3 7.26e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1552244 0.882 rs3846168 chr3:9996925 C/T cg13047869 chr3:10149882 C3orf24 0.52 10.91 0.4 1.6e-25 Alzheimer's disease; BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg02951883 chr7:2050386 MAD1L1 0.51 12.99 0.46 2.18e-34 Bipolar disorder and schizophrenia; BRCA cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg22974920 chr21:40686053 BRWD1 -0.41 -8.96 -0.33 3.5e-18 Cognitive function; BRCA cis rs763121 0.853 rs5750677 chr22:39147715 C/T cg06022373 chr22:39101656 GTPBP1 0.7 15.93 0.53 2.26e-48 Menopause (age at onset); BRCA cis rs11190604 0.767 rs10509743 chr10:102190406 C/T cg07080220 chr10:102295463 HIF1AN 0.5 10.35 0.38 2.59e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9462027 0.630 rs7341267 chr6:34727031 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.01 -0.3 5.38e-15 Systemic lupus erythematosus; BRCA cis rs6878727 0.549 rs2561485 chr5:123645843 C/G cg01806427 chr5:123737813 NA 0.39 9.01 0.34 2.44e-18 Breast cancer; BRCA cis rs56104184 0.775 rs73061689 chr19:49397214 C/T cg21252483 chr19:49399788 TULP2 -0.51 -10.82 -0.39 3.49e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs3771570 1.000 rs1056801 chr2:242292307 T/C cg21155796 chr2:242212141 HDLBP 0.6 9.3 0.35 2.25e-19 Prostate cancer; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg01305625 chr5:131593812 PDLIM4 0.34 8.07 0.3 3.4e-15 Acylcarnitine levels; BRCA trans rs9858542 0.953 rs11711485 chr3:49491983 G/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.4 -0.35 9.72e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6912958 0.559 rs446851 chr6:88043640 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.06 0.4 3.86e-26 Monocyte percentage of white cells; BRCA cis rs3858526 0.676 rs10838752 chr11:5887243 A/G cg02574844 chr11:5959923 NA -0.39 -7.96 -0.3 7.99e-15 DNA methylation (variation); BRCA cis rs9420 0.528 rs11229075 chr11:57391023 A/C cg19752551 chr11:57585705 CTNND1 -0.41 -9.55 -0.35 2.7e-20 Schizophrenia; BRCA trans rs7647973 0.626 rs4855833 chr3:49657441 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -8.24 -0.31 9.44e-16 Menarche (age at onset); BRCA cis rs2075371 1.000 rs2241336 chr7:133979578 A/G cg11752832 chr7:134001865 SLC35B4 0.51 13.45 0.47 1.66e-36 Mean platelet volume; BRCA cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs853679 0.517 rs9380060 chr6:28132603 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA trans rs2204008 0.837 rs11514225 chr12:38076270 G/A cg06521331 chr12:34319734 NA -0.53 -9.65 -0.36 1.17e-20 Bladder cancer; BRCA cis rs929596 0.561 rs6431625 chr2:234637912 T/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -9.94 -0.37 9.64e-22 Total bilirubin levels in HIV-1 infection; BRCA trans rs11098499 1.000 rs6837898 chr4:120179154 C/T cg25214090 chr10:38739885 LOC399744 0.5 10.98 0.4 8.36e-26 Corneal astigmatism; BRCA cis rs754466 0.606 rs11002315 chr10:79617385 T/G cg17075019 chr10:79541650 NA -0.73 -17.63 -0.57 5.75e-57 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.35 8.25 0.31 9.2e-16 Axial length; BRCA cis rs4689592 0.503 rs11945642 chr4:7051065 G/C cg02503808 chr4:7069936 GRPEL1 -0.75 -14.94 -0.51 1.66e-43 Monocyte percentage of white cells; BRCA cis rs7927771 1.000 rs11039390 chr11:47796295 C/G cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs11191270 0.554 rs11191265 chr10:104102118 G/A cg15320455 chr10:103880129 LDB1 0.71 10.44 0.38 1.12e-23 Intelligence (multi-trait analysis); BRCA cis rs34172651 0.517 rs874484 chr16:24803242 T/C cg00339695 chr16:24857497 SLC5A11 0.5 9.96 0.37 8.18e-22 Intelligence (multi-trait analysis); BRCA cis rs4908768 0.501 rs11121199 chr1:8600192 G/A cg20416874 chr1:8611966 RERE -0.28 -8.02 -0.3 5.06e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs4481887 0.927 rs10788765 chr1:248445642 A/G cg00666640 chr1:248458726 OR2T12 -0.3 -8.29 -0.31 6.76e-16 Common traits (Other); BRCA cis rs7246657 0.943 rs10406177 chr19:37907947 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA cis rs36051895 0.664 rs3780372 chr9:5097544 C/T cg02405213 chr9:5042618 JAK2 -0.52 -9.91 -0.36 1.29e-21 Pediatric autoimmune diseases; BRCA cis rs12474201 0.889 rs2346878 chr2:46922870 C/T cg06386533 chr2:46925753 SOCS5 0.91 19.96 0.62 2.87e-69 Height; BRCA cis rs7666738 0.830 rs10025174 chr4:98914172 A/G cg17366294 chr4:99064904 C4orf37 0.41 9.64 0.36 1.28e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs1568889 0.877 rs34351528 chr11:28304293 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 13.13 0.46 4.93e-35 Bipolar disorder; BRCA cis rs897984 0.571 rs7184567 chr16:31021078 C/T cg02466173 chr16:30829666 NA -0.44 -9.85 -0.36 2.17e-21 Dementia with Lewy bodies; BRCA cis rs7666738 0.830 rs17027216 chr4:99009152 G/C cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.24e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg19077165 chr18:44547161 KATNAL2 -0.6 -13.87 -0.48 2.03e-38 Personality dimensions; BRCA cis rs2370759 1.000 rs11597888 chr10:32635834 G/A cg18270830 chr10:32634957 EPC1 0.61 10.26 0.38 5.64e-23 Sexual dysfunction (female); BRCA trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.77 0.42 4.25e-29 Corneal astigmatism; BRCA cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg10802521 chr3:52805072 NEK4 -0.32 -8.18 -0.31 1.53e-15 Bipolar disorder; BRCA cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg03676636 chr4:99064102 C4orf37 0.22 8.1 0.31 2.7e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg14829155 chr15:31115871 NA -0.5 -12.3 -0.44 2.4e-31 Huntington's disease progression; BRCA cis rs1190552 0.841 rs56144019 chr14:102949731 G/A cg18135206 chr14:102964638 TECPR2 0.44 8.51 0.32 1.19e-16 Blood protein levels; BRCA cis rs7829975 0.659 rs4382480 chr8:8721473 C/T cg15556689 chr8:8085844 FLJ10661 0.43 12.03 0.43 3.31e-30 Mood instability; BRCA cis rs911119 1.000 rs13038305 chr20:23610262 C/T cg16589663 chr20:23618590 CST3 0.45 8.56 0.32 8.7e-17 Chronic kidney disease; BRCA cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.8 0.33 1.28e-17 Motion sickness; BRCA cis rs4363385 0.747 rs6665575 chr1:152960506 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -9.0 -0.34 2.56e-18 Inflammatory skin disease; BRCA trans rs941408 1.000 rs1640272 chr19:2800192 A/T cg22153745 chr1:153894579 GATAD2B -0.49 -9.64 -0.36 1.24e-20 Total cholesterol levels; BRCA cis rs7727544 0.557 rs715285 chr5:131485383 A/G cg14196790 chr5:131705035 SLC22A5 0.36 8.91 0.33 5.2e-18 Blood metabolite levels; BRCA cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg13256891 chr4:100009986 ADH5 0.49 10.3 0.38 3.9699999999999997e-23 Alcohol dependence; BRCA cis rs6738485 0.601 rs7566680 chr2:106851657 G/A cg16099169 chr2:106886729 NA -0.4 -8.58 -0.32 7.34e-17 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA cis rs2153535 0.580 rs9406167 chr6:8502852 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.54 0.5 1.33e-41 Motion sickness; BRCA cis rs11690935 0.959 rs10803863 chr2:172535337 T/C cg13550731 chr2:172543902 DYNC1I2 0.92 30.43 0.77 2.21e-126 Schizophrenia; BRCA cis rs9341808 0.754 rs3805925 chr6:80883833 T/C cg08355045 chr6:80787529 NA 0.39 10.01 0.37 5.38e-22 Sitting height ratio; BRCA trans rs9291683 0.588 rs2240722 chr4:10020757 A/G cg26043149 chr18:55253948 FECH 0.4 8.48 0.32 1.59e-16 Bone mineral density; BRCA cis rs7592578 0.766 rs12472081 chr2:191398545 G/A cg10560079 chr2:191398806 TMEM194B -0.79 -13.35 -0.47 4.91e-36 Diastolic blood pressure; BRCA cis rs7666738 0.927 rs4699328 chr4:99055890 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.78e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9818758 0.607 rs113186424 chr3:49272726 T/C cg00383909 chr3:49044727 WDR6 0.71 12.63 0.45 8.28e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs8103278 1.000 rs36091860 chr19:46312880 G/A cg11657440 chr19:46296263 DMWD -0.54 -12.71 -0.45 3.8e-33 Coronary artery disease; BRCA cis rs881375 1.000 rs881375 chr9:123652898 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.04 0.4 4.78e-26 Rheumatoid arthritis; BRCA cis rs523395 0.630 rs616111 chr1:120269991 C/G cg19096424 chr1:120255104 PHGDH -0.43 -9.58 -0.35 2.12e-20 Red blood cell count; BRCA cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg12863693 chr15:85201151 NMB 0.57 12.09 0.43 1.83e-30 Schizophrenia; BRCA cis rs7647973 0.593 rs28535523 chr3:49848414 C/T cg03060546 chr3:49711283 APEH -0.6 -10.41 -0.38 1.47e-23 Menarche (age at onset); BRCA trans rs6479891 1.000 rs2616630 chr10:65213339 A/C cg14819942 chr15:35414228 NA 0.35 8.55 0.32 8.78e-17 Arthritis (juvenile idiopathic); BRCA cis rs2243480 0.803 rs403089 chr7:65517723 T/C cg18252515 chr7:66147081 NA -0.97 -13.78 -0.48 5.15e-38 Diabetic kidney disease; BRCA cis rs9308433 0.733 rs11120300 chr1:214509499 A/T cg06198575 chr1:214491504 SMYD2 -0.43 -10.0 -0.37 5.89e-22 IgG glycosylation; BRCA cis rs780096 0.506 rs2303369 chr2:27715416 C/T cg22903471 chr2:27725779 GCKR -0.36 -8.78 -0.33 1.47e-17 Total body bone mineral density; BRCA trans rs12517041 1.000 rs2081953 chr5:23295682 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs12612619 0.658 rs112794902 chr2:27151586 T/C cg00617064 chr2:27272375 NA -0.3 -7.95 -0.3 8.67e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs17685 0.593 rs56265719 chr7:75796269 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.11 -0.31 2.68e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9811920 0.965 rs9289981 chr3:99868104 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 12.95 0.46 3.02e-34 Axial length; BRCA cis rs711245 0.573 rs11899523 chr2:36800918 T/C cg09467607 chr2:36825704 FEZ2 0.62 15.25 0.52 5.21e-45 Height; BRCA cis rs2204008 0.745 rs12146863 chr12:38502346 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.71 0.39 1.03e-24 Bladder cancer; BRCA cis rs12493885 0.769 rs61791540 chr3:153757041 G/A cg17054900 chr3:154042577 DHX36 -0.47 -8.13 -0.31 2.23e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg22800045 chr5:56110881 MAP3K1 0.64 12.29 0.44 2.59e-31 Initial pursuit acceleration; BRCA trans rs783540 0.656 rs783524 chr15:83284144 A/C cg16105309 chr15:79090380 ADAMTS7 0.34 9.46 0.35 5.56e-20 Schizophrenia; BRCA cis rs7590720 1.000 rs934154 chr2:216901933 C/T cg12620499 chr2:216877984 MREG 0.78 22.03 0.66 1.94e-80 Alcohol dependence; BRCA cis rs7772486 0.720 rs991507 chr6:146023609 G/A cg13319975 chr6:146136371 FBXO30 0.42 9.75 0.36 4.84e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs7943191 0.768 rs34065644 chr11:62371938 C/T cg22862634 chr11:62369728 EML3;MTA2 0.53 10.6 0.39 2.8e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg06046430 chr4:77819534 ANKRD56 -0.59 -13.51 -0.47 9.05e-37 Emphysema distribution in smoking; BRCA cis rs11603020 0.904 rs11606677 chr11:57383377 G/A cg19752551 chr11:57585705 CTNND1 -0.42 -9.63 -0.36 1.41e-20 Blood protein levels; BRCA trans rs61931739 0.635 rs1525895 chr12:33966496 A/G cg26384229 chr12:38710491 ALG10B 0.38 8.73 0.33 2.23e-17 Morning vs. evening chronotype; BRCA cis rs11758351 0.660 rs55643278 chr6:26222888 C/A cg01420254 chr6:26195488 NA 0.55 8.53 0.32 1.04e-16 Gout;Renal underexcretion gout; BRCA trans rs35110281 0.641 rs9978858 chr21:45085552 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.42 8.14 0.31 2.11e-15 Mean corpuscular volume; BRCA trans rs208520 0.690 rs12192710 chr6:66718137 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.97 20.36 0.63 1.98e-71 Exhaled nitric oxide output; BRCA cis rs6964587 1.000 rs2157747 chr7:91750578 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.16 0.31 1.85e-15 Breast cancer; BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg03188948 chr7:1209495 NA 0.74 12.46 0.44 4.9e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8177253 0.634 rs6798547 chr3:133448499 G/A cg11941060 chr3:133502564 NA -0.33 -7.82 -0.3 2.2e-14 Iron status biomarkers; BRCA cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg20362242 chr5:692897 TPPP 0.53 8.64 0.32 4.51e-17 Lung disease severity in cystic fibrosis; BRCA cis rs9649213 0.593 rs6944262 chr7:97985415 T/G cg24562669 chr7:97807699 LMTK2 0.47 12.37 0.44 1.13e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.53 -0.44 2.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs7584330 0.666 rs72620816 chr2:238353604 C/T cg14458575 chr2:238380390 NA 0.72 15.6 0.53 1.03e-46 Prostate cancer; BRCA cis rs1568889 0.838 rs10835273 chr11:28156598 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.8 20.72 0.63 2.49e-73 Bipolar disorder; BRCA cis rs2075371 0.501 rs1643057 chr7:134027521 A/G cg02659138 chr7:134003124 SLC35B4 0.28 8.69 0.33 2.95e-17 Mean platelet volume; BRCA cis rs2180341 1.000 rs6569479 chr6:127606588 A/G cg24812749 chr6:127587940 RNF146 0.84 19.93 0.62 4.29e-69 Breast cancer; BRCA cis rs6570726 0.791 rs379040 chr6:145889035 T/C cg05347473 chr6:146136440 FBXO30 0.39 7.95 0.3 8.46e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.933 rs62505074 chr7:148834780 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.91 0.4 1.61e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6733011 0.578 rs10172158 chr2:99509605 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.35 -8.0 -0.3 5.76e-15 Bipolar disorder; BRCA cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg13010199 chr12:38710504 ALG10B -0.39 -8.96 -0.33 3.58e-18 Morning vs. evening chronotype; BRCA cis rs17818399 0.620 rs6544906 chr2:46863872 A/C cg02822958 chr2:46747628 ATP6V1E2 0.41 8.08 0.3 3.34e-15 Height; BRCA cis rs2742234 0.910 rs2505513 chr10:43633537 C/G cg15436174 chr10:43711423 RASGEF1A -0.41 -8.79 -0.33 1.34e-17 Hirschsprung disease; BRCA cis rs7772486 0.754 rs9399561 chr6:145955687 C/G cg05347473 chr6:146136440 FBXO30 0.43 8.6 0.32 6.02e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4853036 0.951 rs6718298 chr2:70145450 A/C cg02498382 chr2:70120550 SNRNP27 -0.5 -9.88 -0.36 1.55e-21 Colorectal or endometrial cancer; BRCA trans rs2727020 0.521 rs7101761 chr11:49598178 G/A cg11707556 chr5:10655725 ANKRD33B -0.45 -9.84 -0.36 2.25e-21 Coronary artery disease; BRCA cis rs35110281 0.591 rs86139 chr21:44932802 G/A cg04455712 chr21:45112962 RRP1B 0.35 8.76 0.33 1.71e-17 Mean corpuscular volume; BRCA trans rs7618501 0.699 rs2777888 chr3:49898000 A/G cg21659725 chr3:3221576 CRBN 0.53 13.67 0.48 1.61e-37 Intelligence (multi-trait analysis); BRCA cis rs4727027 0.716 rs4727020 chr7:148837317 C/T cg23583168 chr7:148888333 NA -0.72 -15.67 -0.53 4.36e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs12579753 1.000 rs10862371 chr12:82249298 C/T cg07988820 chr12:82153109 PPFIA2 -0.56 -9.16 -0.34 7.17e-19 Resting heart rate; BRCA cis rs7666738 0.830 rs1025203 chr4:99023073 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.55 0.39 4.07e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1451375 0.712 rs11974297 chr7:50618260 A/G cg18232548 chr7:50535776 DDC 0.47 12.15 0.43 1.06e-30 Malaria; BRCA cis rs1218582 0.710 rs7553195 chr1:154837796 T/C cg12436631 chr1:155007014 DCST1;DCST2 0.27 8.43 0.32 2.27e-16 Prostate cancer; BRCA cis rs9039 1.000 rs11075212 chr16:9203899 G/A cg08831531 chr16:9218945 NA -0.65 -12.23 -0.44 4.93e-31 Menopause (age at onset); BRCA cis rs867371 0.892 rs4344697 chr15:82545214 A/T cg00614314 chr15:82944287 LOC80154 0.43 8.95 0.33 3.93e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs10463316 0.894 rs13361316 chr5:150765593 T/C cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.39e-16 Metabolite levels (Pyroglutamine); BRCA trans rs6479891 1.000 rs9414803 chr10:65188069 G/A cg14819942 chr15:35414228 NA 0.35 8.58 0.32 7.31e-17 Arthritis (juvenile idiopathic); BRCA cis rs7098414 0.511 rs7899513 chr10:82150559 G/A cg00277334 chr10:82204260 NA -0.5 -10.7 -0.39 1.05e-24 Post bronchodilator FEV1; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.32 -0.44 1.9e-31 Alzheimer's disease; BRCA cis rs3768617 0.510 rs6424884 chr1:183065904 C/T ch.1.3577855R chr1:183094577 LAMC1 0.68 18.02 0.58 5.02e-59 Fuchs's corneal dystrophy; BRCA cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg22974920 chr21:40686053 BRWD1 0.38 8.71 0.33 2.59e-17 Cognitive function; BRCA cis rs11971779 0.793 rs4732366 chr7:139027845 G/C cg07862535 chr7:139043722 LUC7L2 0.45 12.0 0.43 4.41e-30 Diisocyanate-induced asthma; BRCA cis rs12210905 0.541 rs62617138 chr6:27463766 C/A cg08851530 chr6:28072375 NA 0.81 7.97 0.3 7.34e-15 Hip circumference adjusted for BMI; BRCA cis rs796364 0.951 rs59695400 chr2:201021325 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.53 -9.19 -0.34 5.48e-19 Schizophrenia; BRCA cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.34e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9323205 0.861 rs56137183 chr14:51693463 C/A cg23942311 chr14:51606299 NA -0.41 -8.19 -0.31 1.41e-15 Cancer; BRCA cis rs4237845 0.537 rs10877031 chr12:58266695 A/G cg00677455 chr12:58241039 CTDSP2 0.68 15.77 0.53 1.45e-47 Intelligence (multi-trait analysis); BRCA trans rs3942852 0.774 rs10838812 chr11:48186924 T/C cg15704280 chr7:45808275 SEPT13 -0.53 -10.26 -0.38 5.58e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs2839186 0.708 rs6518285 chr21:47644667 T/C cg13012494 chr21:47604986 C21orf56 0.44 8.77 0.33 1.67e-17 Testicular germ cell tumor; BRCA cis rs8141529 0.702 rs5762870 chr22:29261159 C/T cg15103426 chr22:29168792 CCDC117 0.53 12.56 0.45 1.69e-32 Lymphocyte counts; BRCA cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.22 0.31 1.11e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs936229 0.813 rs3784790 chr15:75081745 G/C cg10253484 chr15:75165896 SCAMP2 -0.52 -9.94 -0.37 9.53e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs72781680 0.716 rs2712056 chr2:23959131 C/T cg08917208 chr2:24149416 ATAD2B 0.66 10.48 0.38 7.73e-24 Lymphocyte counts; BRCA cis rs9463078 0.774 rs4373351 chr6:45276324 T/C cg25276700 chr6:44698697 NA -0.36 -8.13 -0.31 2.22e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg18404041 chr3:52824283 ITIH1 -0.43 -12.81 -0.45 1.32e-33 Bipolar disorder; BRCA cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg18357526 chr6:26021779 HIST1H4A 0.47 8.37 0.31 3.67e-16 Intelligence (multi-trait analysis); BRCA cis rs950776 0.518 rs2292117 chr15:78834689 C/T cg22563815 chr15:78856949 CHRNA5 0.36 8.7 0.33 2.85e-17 Sudden cardiac arrest; BRCA cis rs7766436 0.848 rs13207207 chr6:22579066 G/A cg13666174 chr6:22585274 NA -0.49 -11.29 -0.41 4.4e-27 Coronary artery disease; BRCA cis rs13217239 0.646 rs12209886 chr6:26984757 G/A cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Schizophrenia; BRCA cis rs9815354 0.812 rs73071325 chr3:41809989 T/G cg03022575 chr3:42003672 ULK4 0.72 9.86 0.36 1.95e-21 Pulse pressure;Diastolic blood pressure; BRCA trans rs1005277 0.579 rs2472174 chr10:38375382 A/G cg17830980 chr10:43048298 ZNF37B -0.57 -14.02 -0.49 3.77e-39 Extrinsic epigenetic age acceleration; BRCA cis rs514406 0.755 rs10888754 chr1:53228751 C/G cg24675658 chr1:53192096 ZYG11B 0.55 12.65 0.45 6.62e-33 Monocyte count; BRCA cis rs829661 0.947 rs829665 chr2:30724701 T/A cg12454169 chr2:30669597 LCLAT1 0.98 12.96 0.46 3e-34 Midgestational circulating levels of PBDEs (fetal genetic effect); BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg21226059 chr5:178986404 RUFY1 0.45 11.26 0.41 5.95e-27 Lung cancer; BRCA trans rs2562456 0.754 rs55771551 chr19:21746380 C/T cg25042112 chr7:64838748 ZNF92 -0.45 -8.27 -0.31 8.04e-16 Pain; BRCA cis rs651907 0.557 rs7645391 chr3:101361506 C/G cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.86 -0.3 1.68e-14 Colorectal cancer; BRCA cis rs459571 0.959 rs2810491 chr9:136923331 C/T cg13789015 chr9:136890014 NCRNA00094 -0.64 -13.19 -0.46 2.63e-35 Platelet distribution width; BRCA cis rs7572263 0.724 rs6704765 chr2:209054267 C/G cg23998903 chr2:209048830 C2orf80 -0.41 -8.45 -0.32 2.01e-16 Glioma;Non-glioblastoma glioma; BRCA trans rs11252926 0.589 rs12359901 chr10:475068 A/G cg00953403 chr17:74099816 EXOC7 -0.45 -8.18 -0.31 1.52e-15 Psychosis in Alzheimer's disease; BRCA cis rs10504229 0.683 rs6995355 chr8:58113870 C/T cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA cis rs3096299 0.685 rs3803682 chr16:89544636 C/T cg08392591 chr16:89556376 ANKRD11 0.49 11.63 0.42 1.73e-28 Multiple myeloma (IgH translocation); BRCA cis rs4819052 0.851 rs2330012 chr21:46658592 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 13.92 0.48 1.2e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7552404 0.727 rs7521344 chr1:76318325 C/T cg10523679 chr1:76189770 ACADM -0.59 -11.06 -0.4 4.06e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3741404 0.825 rs60452247 chr11:63981507 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.89 20.8 0.64 8.64e-74 Platelet count; BRCA cis rs4665809 0.590 rs72809688 chr2:26516579 G/A cg22920501 chr2:26401640 FAM59B 0.95 16.34 0.54 1.98e-50 Gut microbiome composition (summer); BRCA cis rs208520 0.507 rs3903670 chr6:66812183 T/C cg07460842 chr6:66804631 NA -1.16 -37.81 -0.83 3.83e-165 Exhaled nitric oxide output; BRCA cis rs66782572 1 rs66782572 chr3:52567617 A/G cg13284614 chr3:52569169 NT5DC2;LOC440957 0.3 8.15 0.31 1.99e-15 Hemoglobin concentration; BRCA cis rs1878931 0.545 rs28603 chr16:3449479 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.58 -8.83 -0.33 1.01e-17 Body mass index (adult); BRCA cis rs3733585 0.673 rs7672947 chr4:9961368 G/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.24 -0.38 7.02e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4237845 0.537 rs2002275 chr12:58283385 A/G cg02175503 chr12:58329896 NA 0.45 8.9 0.33 5.56e-18 Intelligence (multi-trait analysis); BRCA cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg25237894 chr2:233734115 C2orf82 -0.44 -14.16 -0.49 8.36e-40 Coronary artery disease; BRCA cis rs6460942 1.000 rs112794590 chr7:12319426 G/A cg06484146 chr7:12443880 VWDE -0.62 -8.57 -0.32 7.55e-17 Coronary artery disease; BRCA cis rs6570726 0.791 rs400329 chr6:145879442 A/T cg05347473 chr6:146136440 FBXO30 0.42 8.48 0.32 1.57e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg04455712 chr21:45112962 RRP1B 0.41 10.57 0.39 3.59e-24 Mean corpuscular volume; BRCA cis rs2816062 0.813 rs2745318 chr1:18895844 C/T cg18795169 chr1:18902165 NA 0.95 28.7 0.75 4.92e-117 Urate levels in lean individuals; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg18402987 chr7:1209562 NA 0.51 10.05 0.37 3.65e-22 Longevity;Endometriosis; BRCA cis rs2404602 0.716 rs7164060 chr15:76707694 T/C cg23625390 chr15:77176239 SCAPER 0.38 8.98 0.33 3.06e-18 Blood metabolite levels; BRCA trans rs7618501 0.966 rs9882639 chr3:49799475 A/C cg21582582 chr3:182698605 DCUN1D1 0.39 10.16 0.37 1.38e-22 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg00166722 chr3:10149974 C3orf24 0.64 11.13 0.4 1.96e-26 Alzheimer's disease; BRCA cis rs11098499 0.954 rs10024844 chr4:120311528 A/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA trans rs629535 0.911 rs688612 chr8:70011887 C/T cg21567404 chr3:27674614 NA -0.98 -20.45 -0.63 7.02e-72 Dupuytren's disease; BRCA cis rs514406 0.708 rs480299 chr1:53320274 G/T cg16325326 chr1:53192061 ZYG11B 0.55 11.93 0.43 9.04e-30 Monocyte count; BRCA cis rs4481887 0.800 rs4278391 chr1:248450495 C/T cg00666640 chr1:248458726 OR2T12 0.33 8.46 0.32 1.84e-16 Common traits (Other); BRCA cis rs727479 0.502 rs3825800 chr15:51506663 A/C cg19946085 chr15:51559439 CYP19A1 -0.31 -8.53 -0.32 1.03e-16 Estradiol levels; BRCA cis rs11098499 1.000 rs6837898 chr4:120179154 C/T cg09307838 chr4:120376055 NA 0.63 12.66 0.45 6.37e-33 Corneal astigmatism; BRCA cis rs9443645 0.901 rs6940637 chr6:79705845 C/T cg18132916 chr6:79620363 NA -0.49 -11.0 -0.4 6.52e-26 Intelligence (multi-trait analysis); BRCA cis rs1580019 0.563 rs34319173 chr7:32585904 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.47 10.29 0.38 4.42e-23 Cognitive ability; BRCA cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg03146154 chr1:46216737 IPP 0.46 10.16 0.37 1.42e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6882046 0.513 rs2431391 chr5:88046590 C/T cg22951263 chr5:87985283 NA -0.38 -10.73 -0.39 7.9e-25 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs7246657 0.943 rs10404602 chr19:37825633 A/T cg18154014 chr19:37997991 ZNF793 0.61 11.44 0.41 1.11e-27 Coronary artery calcification; BRCA cis rs932287 0.666 rs10840161 chr11:9053824 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.4 8.33 0.31 5.12e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs698813 0.774 rs786625 chr2:44604156 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.05 0.37 3.72e-22 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs6952407 1 rs6952407 chr7:66045512 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.42 -0.32 2.42e-16 Cotinine glucuronidation; BRCA cis rs7666738 0.830 rs7694889 chr4:98855596 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.87e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg08949735 chr16:89699720 DPEP1 -0.45 -8.57 -0.32 7.6e-17 Vitiligo; BRCA cis rs881375 0.526 rs1930785 chr9:123691237 T/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.47 10.21 0.37 8.73e-23 Rheumatoid arthritis; BRCA cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.26 -0.44 3.51e-31 Bipolar disorder; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.54 -0.32 9.62e-17 Total body bone mineral density; BRCA cis rs2046867 0.818 rs17010184 chr3:72870242 A/T cg25664220 chr3:72788482 NA 0.52 11.42 0.41 1.3e-27 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.02 0.3 5.04e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9443645 0.527 rs3902856 chr6:79699837 C/T cg05283184 chr6:79620031 NA -0.36 -8.09 -0.3 2.95e-15 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg20644253 chr19:19431407 KIAA0892;SF4 0.6 11.98 0.43 5.87e-30 Tonsillectomy; BRCA cis rs10851411 0.657 rs1048571 chr15:42862024 A/G cg21293051 chr15:42870591 STARD9 0.51 8.77 0.33 1.58e-17 Glucose homeostasis traits; BRCA cis rs8031584 0.872 rs11634761 chr15:31243173 A/C cg14829155 chr15:31115871 NA -0.42 -9.36 -0.35 1.36e-19 Huntington's disease progression; BRCA cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA cis rs829880 0.570 rs844205 chr12:98846053 A/G cg25150519 chr12:98850993 NA 0.65 14.87 0.51 3.52e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.714 rs17293608 chr10:1056252 C/T cg10556349 chr10:835070 NA 0.59 8.35 0.31 4.39e-16 Eosinophil percentage of granulocytes; BRCA cis rs3008870 1.000 rs3008853 chr1:67385488 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.74 0.65 7.41e-79 Lymphocyte percentage of white cells; BRCA trans rs7200543 1.000 rs6498541 chr16:15140657 A/G cg24683922 chr1:11983373 KIAA2013 -0.36 -8.26 -0.31 8.23e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs1401999 0.546 rs56889301 chr3:183675315 T/C cg20387954 chr3:183756860 HTR3D 0.36 8.33 0.31 4.75e-16 Anterior chamber depth; BRCA cis rs4332037 0.624 rs58169303 chr7:1883274 T/C cg12432903 chr7:1882776 MAD1L1 0.44 7.95 0.3 8.54e-15 Bipolar disorder; BRCA cis rs67460515 0.892 rs11710489 chr3:161093332 G/A cg04691961 chr3:161091175 C3orf57 -0.4 -9.13 -0.34 8.56e-19 Parkinson's disease; BRCA cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.959 rs798556 chr7:2759002 C/A cg23285459 chr7:2802560 GNA12 -0.34 -8.43 -0.32 2.24e-16 Height; BRCA cis rs9467711 0.651 rs35402046 chr6:26099472 G/A cg21479132 chr6:26055353 NA 0.56 7.93 0.3 9.65e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs11249608 0.636 rs62393070 chr5:178447943 A/G cg21905437 chr5:178450457 ZNF879 0.48 9.46 0.35 5.93e-20 Pubertal anthropometrics; BRCA cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7246657 0.722 rs10402671 chr19:38117086 C/T cg14683738 chr19:37701593 ZNF585B 0.47 8.11 0.31 2.51e-15 Coronary artery calcification; BRCA cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg15541040 chr2:3486749 NA 0.47 10.42 0.38 1.43e-23 Neurofibrillary tangles; BRCA cis rs10501293 0.917 rs7951266 chr11:43110728 C/T cg03447554 chr11:43094025 NA 0.43 8.21 0.31 1.23e-15 Cognitive performance; BRCA cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg05022225 chr19:49866942 DKKL1;TEAD2 0.39 8.42 0.32 2.49e-16 Multiple sclerosis; BRCA cis rs8072100 0.967 rs11079784 chr17:45702280 A/G cg25173405 chr17:45401733 C17orf57 0.44 8.95 0.33 3.92e-18 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg08132940 chr7:1081526 C7orf50 -0.46 -7.95 -0.3 8.38e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2576037 0.623 rs2576040 chr18:44582027 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -12.12 -0.43 1.38e-30 Personality dimensions; BRCA trans rs61931739 0.534 rs11052974 chr12:34029877 T/G cg26384229 chr12:38710491 ALG10B 0.68 14.43 0.5 4.38e-41 Morning vs. evening chronotype; BRCA cis rs67460515 0.563 rs6794882 chr3:160851849 G/A cg17135325 chr3:160939158 NMD3 0.42 7.9 0.3 1.27e-14 Parkinson's disease; BRCA cis rs8177253 1.000 rs8177262 chr3:133480652 A/G cg11941060 chr3:133502564 NA 0.5 12.19 0.43 6.82e-31 Iron status biomarkers; BRCA cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg18305652 chr10:134549665 INPP5A 0.42 11.58 0.42 2.81e-28 Migraine; BRCA cis rs7086627 0.515 rs4934189 chr10:82214792 C/T cg01528321 chr10:82214614 TSPAN14 0.63 14.24 0.49 3.58e-40 Post bronchodilator FEV1; BRCA cis rs798554 0.679 rs13230995 chr7:2887284 G/A cg04166393 chr7:2884313 GNA12 0.64 13.82 0.48 3.5e-38 Height; BRCA cis rs9309711 0.666 rs11127430 chr2:3485242 G/C cg15506890 chr2:3487001 NA -0.59 -13.33 -0.47 5.98e-36 Neurofibrillary tangles; BRCA cis rs9381040 1.000 rs2093396 chr6:41155000 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.39 -8.29 -0.31 6.77e-16 Alzheimer's disease (late onset); BRCA cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg01877450 chr7:97915802 BRI3 0.38 8.75 0.33 1.9e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg04450456 chr4:17643702 FAM184B 0.32 9.02 0.34 2.14e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11098499 0.863 rs10009626 chr4:120470005 T/C cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs7100689 0.577 rs2185427 chr10:82056667 G/T cg01528321 chr10:82214614 TSPAN14 -0.76 -16.86 -0.55 4.75e-53 Post bronchodilator FEV1; BRCA cis rs6430585 0.583 rs3087343 chr2:136622543 T/G cg07169764 chr2:136633963 MCM6 1.28 28.78 0.75 1.99e-117 Corneal structure; BRCA cis rs17401966 0.838 rs4846209 chr1:10322054 G/A cg03954927 chr1:10346856 KIF1B 0.42 13.41 0.47 2.63e-36 Hepatocellular carcinoma; BRCA cis rs3768617 0.510 rs3818417 chr1:183079376 G/A ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA cis rs11711311 1.000 rs6792447 chr3:113508335 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.38 10.08 0.37 2.76e-22 IgG glycosylation; BRCA cis rs113835537 0.529 rs4930378 chr11:66255515 T/C cg24851651 chr11:66362959 CCS 0.43 8.22 0.31 1.12e-15 Airway imaging phenotypes; BRCA trans rs877282 0.898 rs12357995 chr10:765739 T/C cg22713356 chr15:30763199 NA 1.3 24.11 0.69 7.71e-92 Uric acid levels; BRCA cis rs875971 1.000 rs6460292 chr7:65810075 G/A cg18876405 chr7:65276391 NA -0.54 -12.94 -0.46 3.52e-34 Aortic root size; BRCA cis rs11105298 0.891 rs11105316 chr12:89925200 T/G cg00757033 chr12:89920650 WDR51B 0.54 11.14 0.4 1.92e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7917772 0.582 rs10883744 chr10:104347247 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs17601876 0.807 rs10519299 chr15:51551346 C/G cg19946085 chr15:51559439 CYP19A1 -0.38 -10.83 -0.39 3.36e-25 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs2439831 0.850 rs60883262 chr15:44076503 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.67 11.74 0.42 5.64e-29 Lung cancer in ever smokers; BRCA cis rs7572733 0.534 rs1435568 chr2:198762879 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.31 0.38 3.72e-23 Dermatomyositis; BRCA trans rs60843830 1.000 rs3791220 chr2:227066 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.64 14.18 0.49 7.29e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 8.93 0.33 4.38e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17376456 0.825 rs66564678 chr5:93165894 C/T cg21475434 chr5:93447410 FAM172A 0.69 8.86 0.33 7.58e-18 Diabetic retinopathy; BRCA cis rs600806 0.627 rs2359652 chr1:110008720 T/A cg20591472 chr1:110008990 SYPL2 0.31 7.92 0.3 1.03e-14 Intelligence (multi-trait analysis); BRCA cis rs7824557 0.806 rs10503418 chr8:11118983 C/T cg21775007 chr8:11205619 TDH -0.6 -11.89 -0.43 1.31e-29 Retinal vascular caliber; BRCA cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg18404041 chr3:52824283 ITIH1 -0.4 -12.17 -0.43 8.18e-31 Electroencephalogram traits; BRCA cis rs61931739 0.500 rs3922568 chr12:34560107 A/C cg06521331 chr12:34319734 NA -0.52 -10.27 -0.38 5.32e-23 Morning vs. evening chronotype; BRCA cis rs11098499 0.955 rs1511019 chr4:120166007 T/G cg09307838 chr4:120376055 NA 0.63 12.74 0.45 2.8e-33 Corneal astigmatism; BRCA cis rs8114671 0.836 rs6120778 chr20:33565169 T/C cg07148914 chr20:33460835 GGT7 0.42 9.15 0.34 7.41e-19 Height; BRCA cis rs8114671 0.562 rs6087643 chr20:33474462 C/T cg07148914 chr20:33460835 GGT7 0.38 8.54 0.32 1e-16 Height; BRCA cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg21427119 chr20:30132790 HM13 -0.41 -8.78 -0.33 1.53e-17 Mean corpuscular hemoglobin; BRCA cis rs11671664 0.732 rs67775326 chr19:46160969 A/G cg13320842 chr19:46175254 GIPR 0.61 10.48 0.38 7.86e-24 Type 2 diabetes;Body mass index;Body mass index (SNP x SNP interaction); BRCA cis rs561341 1.000 rs497479 chr17:30328605 C/T cg00745463 chr17:30367425 LRRC37B -0.51 -8.44 -0.32 2.08e-16 Hip circumference adjusted for BMI; BRCA trans rs6479891 1.000 rs724553 chr10:65140384 G/C cg14819942 chr15:35414228 NA 0.35 8.65 0.32 4.02e-17 Arthritis (juvenile idiopathic); BRCA cis rs67981189 0.593 rs7154437 chr14:71441385 A/G cg15816911 chr14:71606274 NA 0.36 8.41 0.32 2.72e-16 Schizophrenia; BRCA cis rs509477 1.000 rs531558 chr18:32575286 A/T cg00449728 chr18:32561817 MAPRE2 -0.34 -7.84 -0.3 1.84e-14 Cerebrospinal fluid AB1-42 levels; BRCA cis rs9300255 0.544 rs1727310 chr12:123660510 A/G cg00376283 chr12:123451042 ABCB9 0.54 10.24 0.38 6.99e-23 Neutrophil percentage of white cells; BRCA cis rs7552404 0.920 rs2788654 chr1:76219569 C/T cg03433033 chr1:76189801 ACADM 0.73 18.53 0.59 1.12e-61 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1467026 0.606 rs9814180 chr3:12818386 A/G cg24848339 chr3:12840334 CAND2 0.46 12.1 0.43 1.65e-30 P wave duration; BRCA cis rs875971 0.862 rs4718383 chr7:66108409 T/C cg18876405 chr7:65276391 NA -0.49 -10.65 -0.39 1.78e-24 Aortic root size; BRCA cis rs908922 0.676 rs568661 chr1:152519787 C/A cg20991723 chr1:152506922 NA 0.37 8.32 0.31 5.36e-16 Hair morphology; BRCA cis rs2282802 0.677 rs9686454 chr5:139627813 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.27 0.31 7.56e-16 Intelligence (multi-trait analysis); BRCA cis rs60843830 0.661 rs7561648 chr2:105171 G/T cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.7 0.33 2.8e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs704795 0.775 rs4665975 chr2:27626017 A/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.6 -0.32 6.28e-17 Menopause (age at onset); BRCA cis rs35306767 0.903 rs11253458 chr10:882843 T/C cg26597838 chr10:835615 NA 1.03 18.04 0.58 3.99e-59 Eosinophil percentage of granulocytes; BRCA trans rs35110281 0.755 rs4819270 chr21:45020919 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.46 0.38 9.35e-24 Mean corpuscular volume; BRCA cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg19052272 chr2:3704530 ALLC 0.5 11.72 0.42 7.44e-29 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs2554380 0.943 rs2585038 chr15:84337258 A/G cg14598478 chr15:84363061 ADAMTSL3 -0.33 -7.97 -0.3 7.53e-15 Height; BRCA cis rs6138458 1.000 rs227616 chr20:24908811 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.76 0.7 2.17e-95 Blood protein levels; BRCA cis rs6121246 0.559 rs6060952 chr20:30382108 T/G cg21427119 chr20:30132790 HM13 -0.35 -7.86 -0.3 1.6e-14 Mean corpuscular hemoglobin; BRCA cis rs7633770 0.786 rs950190 chr3:46683377 C/T cg11219411 chr3:46661640 NA 0.65 16.96 0.56 1.59e-53 Coronary artery disease; BRCA cis rs7772486 0.875 rs6570738 chr6:146412695 G/A cg23711669 chr6:146136114 FBXO30 0.67 15.63 0.53 7.19e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs2204008 0.606 rs1581358 chr12:38391582 G/T cg26384229 chr12:38710491 ALG10B 0.76 16.85 0.55 5.61e-53 Bladder cancer; BRCA cis rs6952808 0.723 rs4721282 chr7:2025040 A/G cg14004847 chr7:1930337 MAD1L1 -0.41 -8.63 -0.32 4.77e-17 Bipolar disorder and schizophrenia; BRCA cis rs2243480 1.000 rs56291018 chr7:65390339 G/A cg18252515 chr7:66147081 NA -0.9 -12.9 -0.45 5.33e-34 Diabetic kidney disease; BRCA cis rs2839186 0.770 rs2330353 chr21:47669648 T/A cg11766577 chr21:47581405 C21orf56 -0.49 -10.93 -0.4 1.28e-25 Testicular germ cell tumor; BRCA cis rs12762955 0.519 rs10795306 chr10:1019138 A/T cg26597838 chr10:835615 NA -0.52 -9.63 -0.36 1.38e-20 Response to angiotensin II receptor blocker therapy; BRCA cis rs1691799 0.867 rs6581677 chr12:66770379 C/G cg16791601 chr12:66731901 HELB -0.64 -17.83 -0.58 5.06e-58 White blood cell count (basophil); BRCA cis rs7819412 0.561 rs2001328 chr8:10987199 T/C cg21775007 chr8:11205619 TDH -0.46 -9.65 -0.36 1.13e-20 Triglycerides; BRCA cis rs10463316 0.832 rs246483 chr5:150731062 C/G cg03212797 chr5:150827313 SLC36A1 -0.48 -9.05 -0.34 1.74e-18 Metabolite levels (Pyroglutamine); BRCA cis rs2762353 0.935 rs1892249 chr6:25768992 A/G cg03517284 chr6:25882590 NA 0.46 10.31 0.38 3.82e-23 Blood metabolite levels; BRCA cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.91 -0.3 1.15e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg06481639 chr22:41940642 POLR3H -0.51 -8.42 -0.32 2.42e-16 Vitiligo; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.87 0.36 1.74e-21 Gut microbiome composition (summer); BRCA cis rs1707322 1.000 rs4489497 chr1:46438698 C/T cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 4.04e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2549003 0.966 rs10072571 chr5:131816711 A/C cg02551604 chr5:131831745 NA -0.39 -14.68 -0.5 2.84e-42 Asthma (sex interaction); BRCA cis rs4481887 0.927 rs4603165 chr1:248473799 T/A cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs1018836 0.923 rs2023626 chr8:91619264 G/T cg16814680 chr8:91681699 NA 0.6 12.93 0.46 3.99e-34 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs6089829 0.962 rs4809456 chr20:61660849 C/A cg17470723 chr8:74884337 TCEB1 0.41 8.75 0.33 1.95e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs11246602 1 rs11246602 chr11:51512090 T/C cg03929089 chr4:120376271 NA 0.63 8.01 0.3 5.41e-15 HDL cholesterol levels;HDL cholesterol; BRCA cis rs877282 0.786 rs10904558 chr10:797509 C/T cg17470449 chr10:769945 NA 0.48 8.4 0.32 2.88e-16 Uric acid levels; BRCA cis rs7917772 0.503 rs61871067 chr10:104295382 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 16.59 0.55 1.09e-51 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13256369 1.000 rs9329166 chr8:8576655 C/T cg06671706 chr8:8559999 CLDN23 0.41 8.16 0.31 1.78e-15 Obesity-related traits; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg16606324 chr3:10149918 C3orf24 0.57 11.21 0.41 9.2e-27 Alzheimer's disease; BRCA cis rs7607369 0.536 rs13013510 chr2:219667227 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.15 -0.37 1.48e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs908922 0.676 rs7531317 chr1:152528439 A/C cg20991723 chr1:152506922 NA 0.41 9.24 0.34 3.73e-19 Hair morphology; BRCA cis rs798554 0.591 rs1713913 chr7:2895627 C/T cg13628971 chr7:2884303 GNA12 0.48 11.25 0.41 6.34e-27 Height; BRCA cis rs7091068 0.567 rs1572773 chr10:95432968 T/C cg20715218 chr10:95462985 C10orf4 0.48 10.28 0.38 4.96e-23 Urinary tract infection frequency; BRCA cis rs7520050 0.807 rs3013594 chr1:46138000 T/C cg24296786 chr1:45957014 TESK2 -0.45 -10.09 -0.37 2.61e-22 Red blood cell count;Reticulocyte count; BRCA cis rs9486719 0.947 rs9386648 chr6:97035656 T/C cg06623918 chr6:96969491 KIAA0776 -0.75 -13.21 -0.46 2.19e-35 Migraine;Coronary artery disease; BRCA cis rs1997103 0.954 rs1997099 chr7:55405540 T/C cg17469321 chr7:55412551 NA 0.5 9.61 0.36 1.58e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs6763687 0.796 rs34814303 chr3:171781839 C/A cg16233210 chr3:171778391 FNDC3B 0.38 8.37 0.31 3.58e-16 Red cell distribution width; BRCA cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.21 -0.37 9.06e-23 Gut microbiome composition (summer); BRCA cis rs2762353 0.776 rs1165178 chr6:25827516 A/G cg03264133 chr6:25882463 NA -0.53 -11.99 -0.43 4.97e-30 Blood metabolite levels; BRCA cis rs4660306 0.961 rs1494813 chr1:45957290 T/C cg24296786 chr1:45957014 TESK2 0.42 8.38 0.31 3.31e-16 Homocysteine levels; BRCA cis rs2011503 0.941 rs113145184 chr19:19419984 T/C cg11584989 chr19:19387371 SF4 0.66 14.26 0.49 2.8e-40 Bipolar disorder; BRCA cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg06618935 chr21:46677482 NA -0.36 -8.1 -0.31 2.81e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1371614 0.655 rs509047 chr2:27128529 T/C cg12368169 chr2:27073192 DPYSL5 -0.3 -9.09 -0.34 1.25e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10751667 0.666 rs10902241 chr11:949129 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA cis rs2153535 0.580 rs6902001 chr6:8477055 T/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs875971 0.638 rs6460305 chr7:66060408 G/A cg18876405 chr7:65276391 NA -0.62 -15.57 -0.52 1.42e-46 Aortic root size; BRCA cis rs4845875 0.557 rs6659541 chr1:11836442 G/A cg24844545 chr1:11908347 NPPA 0.32 8.09 0.3 2.93e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs7605378 0.528 rs1704190 chr2:200760629 G/A cg23649088 chr2:200775458 C2orf69 0.72 16.2 0.54 1.1e-49 Osteoporosis; BRCA cis rs2153535 0.601 rs2015281 chr6:8539673 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.7 0.33 2.7e-17 Motion sickness; BRCA cis rs7246657 0.722 rs2909093 chr19:38199462 T/C cg23950597 chr19:37808831 NA 0.52 8.78 0.33 1.49e-17 Coronary artery calcification; BRCA cis rs11583043 1.000 rs7541397 chr1:101322866 C/T cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.4 -8.89 -0.33 6.38e-18 Ulcerative colitis;Inflammatory bowel disease; BRCA trans rs6089829 0.962 rs9679865 chr20:61666132 C/G cg15934090 chr1:100435551 SLC35A3 0.35 8.18 0.31 1.48e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs11098499 0.954 rs56270433 chr4:120406030 C/T cg09307838 chr4:120376055 NA 0.72 15.28 0.52 3.69e-45 Corneal astigmatism; BRCA cis rs35110281 0.501 rs162378 chr21:44925905 A/G cg04455712 chr21:45112962 RRP1B -0.35 -8.54 -0.32 9.73e-17 Mean corpuscular volume; BRCA cis rs9291683 0.588 rs4280729 chr4:10013861 C/T cg11266682 chr4:10021025 SLC2A9 0.48 12.76 0.45 2.23e-33 Bone mineral density; BRCA cis rs17401966 1.000 rs58053556 chr1:10442903 A/G cg03954927 chr1:10346856 KIF1B 0.45 12.09 0.43 1.85e-30 Hepatocellular carcinoma; BRCA cis rs9399137 0.507 rs4895437 chr6:135317354 G/A cg22676075 chr6:135203613 NA 0.44 8.6 0.32 6.06e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg15556689 chr8:8085844 FLJ10661 0.37 9.14 0.34 8.48e-19 Retinal vascular caliber; BRCA cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg06618935 chr21:46677482 NA -0.37 -8.3 -0.31 6.41e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10267417 0.535 rs10272487 chr7:19862415 A/T cg05791153 chr7:19748676 TWISTNB 0.53 10.19 0.37 1.07e-22 Night sleep phenotypes; BRCA cis rs9309711 0.621 rs7586472 chr2:3473670 G/A cg15506890 chr2:3487001 NA -0.52 -11.3 -0.41 3.96e-27 Neurofibrillary tangles; BRCA cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg06552810 chr11:31128660 NA -0.39 -8.71 -0.33 2.51e-17 Red blood cell count; BRCA cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11644478 chr21:40555479 PSMG1 -0.51 -10.84 -0.39 3.13e-25 Menarche (age at onset); BRCA cis rs7179456 0.513 rs593742 chr15:59045774 A/G cg05156742 chr15:59063176 FAM63B 0.42 8.56 0.32 8.33e-17 Asperger disorder; BRCA cis rs875971 0.660 rs3764903 chr7:66098482 G/A cg18876405 chr7:65276391 NA -0.62 -15.19 -0.52 1.02e-44 Aortic root size; BRCA cis rs760805 1.000 rs3845302 chr1:25259884 C/G cg22509179 chr1:25234806 RUNX3 -0.56 -14.46 -0.5 3.29e-41 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2836974 0.568 rs7282604 chr21:40536910 C/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.37 -0.31 3.58e-16 Cognitive function; BRCA cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs72928364 1.000 rs67991823 chr3:100631677 C/T cg10123952 chr3:100791384 NA 0.54 7.94 0.3 8.87e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs10751667 0.666 rs7936830 chr11:959686 A/G ch.11.42038R chr11:967971 AP2A2 0.52 16.63 0.55 7.59e-52 Alzheimer's disease (late onset); BRCA cis rs12824058 0.831 rs11060826 chr12:130809931 G/C cg24838063 chr12:130822603 PIWIL1 0.68 16.73 0.55 2.13e-52 Menopause (age at onset); BRCA cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -8.03 -0.3 4.74e-15 Total body bone mineral density; BRCA cis rs4566357 0.615 rs12618793 chr2:227909552 T/C cg05526886 chr2:227700861 RHBDD1 -0.39 -8.03 -0.3 4.81e-15 Coronary artery disease; BRCA cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg06671706 chr8:8559999 CLDN23 0.42 8.06 0.3 3.83e-15 Obesity-related traits; BRCA cis rs4665809 0.941 rs1470096 chr2:26311482 T/C cg26314531 chr2:26401878 FAM59B -0.78 -12.34 -0.44 1.54e-31 Gut microbiome composition (summer); BRCA cis rs1710278 0.967 rs1278271 chr10:127747972 G/A cg22975853 chr10:127789788 ADAM12 0.32 8.21 0.31 1.21e-15 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs9457247 0.905 rs377232 chr6:167409638 C/A cg00271210 chr6:167070053 RPS6KA2 -0.33 -8.73 -0.33 2.22e-17 Crohn's disease; BRCA cis rs4862750 0.872 rs6821507 chr4:187876829 G/T cg22105103 chr4:187893119 NA -0.38 -11.77 -0.42 4.2e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs6879260 1.000 rs7730585 chr5:179733440 T/C cg23221052 chr5:179740743 GFPT2 -0.64 -13.49 -0.47 1.17e-36 Height; BRCA cis rs7072216 0.763 rs942805 chr10:100168372 G/A cg26618903 chr10:100175079 PYROXD2 -0.31 -9.01 -0.34 2.38e-18 Metabolite levels; BRCA cis rs17376456 0.877 rs28575883 chr5:93346035 T/C cg21475434 chr5:93447410 FAM172A 0.67 8.72 0.33 2.43e-17 Diabetic retinopathy; BRCA cis rs6831352 0.819 rs1154401 chr4:100009738 G/C cg13256891 chr4:100009986 ADH5 0.47 9.7 0.36 7.83e-21 Alcohol dependence; BRCA trans rs6076960 0.652 rs6085467 chr20:6259004 T/C cg21095983 chr6:86352623 SYNCRIP 0.36 8.27 0.31 7.68e-16 Smooth-surface caries; BRCA cis rs514406 0.858 rs574853 chr1:53310959 A/T cg16325326 chr1:53192061 ZYG11B 0.69 17.45 0.57 4.84e-56 Monocyte count; BRCA trans rs1814175 0.519 rs3913237 chr11:49551828 G/A cg15704280 chr7:45808275 SEPT13 0.7 14.24 0.49 3.57e-40 Height; BRCA cis rs2880765 0.835 rs28874135 chr15:86031503 G/A cg10818794 chr15:86012489 AKAP13 -0.31 -8.61 -0.32 5.47e-17 Coronary artery disease; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg09177884 chr7:1199841 ZFAND2A -0.39 -9.02 -0.34 2.26e-18 Longevity;Endometriosis; BRCA cis rs858239 0.601 rs10239760 chr7:23149950 C/T cg23682824 chr7:23144976 KLHL7 0.4 10.42 0.38 1.39e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs7824557 0.701 rs2060465 chr8:11162609 T/C cg21775007 chr8:11205619 TDH 0.61 11.95 0.43 7.8e-30 Retinal vascular caliber; BRCA cis rs10782582 0.593 rs12129523 chr1:76129223 C/A cg10523679 chr1:76189770 ACADM -0.47 -9.18 -0.34 5.94e-19 Daytime sleep phenotypes; BRCA cis rs7246967 0.673 rs8103430 chr19:22931498 A/G cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs13046373 0.535 rs35909098 chr21:32021649 C/T cg16812893 chr21:31813075 KRTAP15-1 0.37 9.39 0.35 1e-19 HDL cholesterol; BRCA cis rs9733 0.596 rs2275236 chr1:150669952 A/G cg18016565 chr1:150552671 MCL1 -0.36 -8.27 -0.31 7.51e-16 Tonsillectomy; BRCA trans rs7615952 0.673 rs35955861 chr3:125626201 T/C cg07211511 chr3:129823064 LOC729375 -0.96 -13.54 -0.47 6.91e-37 Blood pressure (smoking interaction); BRCA cis rs12971120 0.504 rs11665154 chr18:72147006 A/C cg25817165 chr18:72167213 CNDP2 -0.49 -11.59 -0.42 2.62e-28 Refractive error; BRCA cis rs17270561 0.609 rs1937132 chr6:25757017 A/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.7 0.33 2.82e-17 Iron status biomarkers; BRCA cis rs6547741 1.000 rs6547741 chr2:27855924 G/A cg27432699 chr2:27873401 GPN1 0.43 9.19 0.34 5.5e-19 Oral cavity cancer; BRCA cis rs11711311 1.000 rs7649590 chr3:113447267 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.49 -10.89 -0.4 1.88e-25 IgG glycosylation; BRCA cis rs12413816 0.963 rs10796116 chr10:13762786 C/T cg16485048 chr10:13749193 FRMD4A -0.58 -14.42 -0.5 5.08e-41 Red cell distribution width; BRCA cis rs1801251 0.835 rs1446310 chr2:233683245 G/C cg08000102 chr2:233561755 GIGYF2 -0.59 -12.68 -0.45 5.09e-33 Coronary artery disease; BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.96 0.33 3.45e-18 Tonsillectomy; BRCA cis rs2637266 1.000 rs4979784 chr10:78355476 T/A cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs35306767 0.903 rs11253460 chr10:887382 C/G cg20503657 chr10:835505 NA 1.05 18.71 0.59 1.3e-62 Eosinophil percentage of granulocytes; BRCA cis rs17270561 0.609 rs9379786 chr6:25730255 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs6740322 0.841 rs10210507 chr2:43556636 G/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.12 -0.43 1.38e-30 Coronary artery disease; BRCA cis rs67460515 0.563 rs7618924 chr3:160855599 A/G cg03342759 chr3:160939853 NMD3 -0.72 -14.8 -0.51 7.47e-43 Parkinson's disease; BRCA cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg08917208 chr2:24149416 ATAD2B 0.93 13.57 0.47 4.72e-37 Lymphocyte counts; BRCA cis rs3806843 0.676 rs778593 chr5:140027216 T/C cg16179182 chr5:140090404 VTRNA1-1 0.47 10.73 0.39 7.92e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs72928364 0.929 rs13060849 chr3:100773483 A/C cg10123952 chr3:100791384 NA 0.58 8.43 0.32 2.3e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg13047869 chr3:10149882 C3orf24 0.6 12.62 0.45 9.38e-33 Alzheimer's disease; BRCA cis rs2204008 0.744 rs11519905 chr12:38222959 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs4727027 0.866 rs2373437 chr7:148779032 T/C cg23583168 chr7:148888333 NA -0.81 -18.33 -0.59 1.34e-60 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs7618501 1.000 rs11709680 chr3:49745188 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.05 -0.56 4.99e-54 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.893 rs11729640 chr4:99052699 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs12142240 0.628 rs56126529 chr1:46808860 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs11711311 1.000 rs3773682 chr3:113520576 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.34 8.64 0.32 4.46e-17 IgG glycosylation; BRCA cis rs35110281 0.782 rs6518309 chr21:45047992 C/A cg04455712 chr21:45112962 RRP1B 0.44 10.4 0.38 1.71e-23 Mean corpuscular volume; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg14820908 chr5:178986412 RUFY1 -0.46 -12.02 -0.43 3.77e-30 Lung cancer; BRCA cis rs4595586 0.679 rs5017082 chr12:39314564 A/C cg26384229 chr12:38710491 ALG10B -0.36 -7.82 -0.3 2.23e-14 Morning vs. evening chronotype; BRCA trans rs11039798 0.588 rs113800184 chr11:48756855 G/A cg15704280 chr7:45808275 SEPT13 0.62 10.36 0.38 2.45e-23 Axial length; BRCA cis rs7618501 0.602 rs6780731 chr3:50017478 A/G cg24110177 chr3:50126178 RBM5 -0.37 -9.81 -0.36 2.89e-21 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.508 rs7652191 chr3:52610415 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.29 -0.35 2.31e-19 Electroencephalogram traits; BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 19.2 0.6 3.14e-65 Alzheimer's disease; BRCA cis rs2839186 0.771 rs13046451 chr21:47641373 T/A cg11766577 chr21:47581405 C21orf56 0.5 10.79 0.39 4.71e-25 Testicular germ cell tumor; BRCA cis rs4727443 0.653 rs6465759 chr7:99587980 T/C cg22004693 chr7:99632812 ZKSCAN1 -0.38 -8.51 -0.32 1.28e-16 Interstitial lung disease; BRCA cis rs12579753 0.917 rs7138533 chr12:82187885 C/G cg07988820 chr12:82153109 PPFIA2 -0.49 -8.42 -0.32 2.38e-16 Resting heart rate; BRCA cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs4891159 0.790 rs683306 chr18:74112473 C/G cg24786174 chr18:74118243 ZNF516 -0.73 -18.24 -0.59 3.68e-60 Longevity; BRCA cis rs250677 0.687 rs40149 chr5:148444275 A/T cg18129178 chr5:148520854 ABLIM3 -0.58 -11.64 -0.42 1.59e-28 Breast cancer; BRCA cis rs7618501 0.633 rs9866695 chr3:50069452 G/T cg24308560 chr3:49941425 MST1R 0.4 8.49 0.32 1.47e-16 Intelligence (multi-trait analysis); BRCA cis rs13217239 0.646 rs10946888 chr6:26951678 A/G cg12292205 chr6:26970375 C6orf41 0.58 13.01 0.46 1.76e-34 Schizophrenia; BRCA cis rs270601 0.683 rs81598 chr5:131587960 C/G cg04518342 chr5:131593106 PDLIM4 0.37 8.69 0.32 3.13e-17 Acylcarnitine levels; BRCA cis rs769267 0.895 rs2916069 chr19:19520358 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.78 0.42 4.11e-29 Tonsillectomy; BRCA cis rs7824557 0.507 rs7010590 chr8:11062882 C/T cg21775007 chr8:11205619 TDH 0.44 9.03 0.34 2.07e-18 Retinal vascular caliber; BRCA cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg24812749 chr6:127587940 RNF146 0.68 15.41 0.52 8.21e-46 Breast cancer; BRCA cis rs72772090 0.539 rs11747148 chr5:96112863 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.08 -0.43 2.05e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6028335 0.622 rs73621984 chr20:37639209 A/G cg16355469 chr20:37678765 NA 0.44 8.33 0.31 5.01e-16 Alcohol and nicotine co-dependence; BRCA cis rs9443645 0.901 rs4706079 chr6:79615208 G/A cg09184832 chr6:79620586 NA -0.51 -11.21 -0.41 9.04e-27 Intelligence (multi-trait analysis); BRCA cis rs910316 0.737 rs175045 chr14:75475275 A/C cg08847533 chr14:75593920 NEK9 -0.74 -16.86 -0.55 5.07e-53 Height; BRCA cis rs60871478 0.898 rs62432897 chr7:825429 A/G cg05535760 chr7:792225 HEATR2 0.84 14.66 0.5 3.52e-42 Cerebrospinal P-tau181p levels; BRCA cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.55 -0.35 2.8e-20 Tonsillectomy; BRCA cis rs832540 0.931 rs1466008 chr5:56213406 G/C cg24531977 chr5:56204891 C5orf35 -0.44 -8.99 -0.33 2.86e-18 Coronary artery disease; BRCA cis rs6547741 0.904 rs2384659 chr2:27856793 G/A cg27432699 chr2:27873401 GPN1 0.43 9.11 0.34 1.07e-18 Oral cavity cancer; BRCA cis rs7618915 0.547 rs2268027 chr3:52766606 G/A cg18404041 chr3:52824283 ITIH1 -0.43 -12.78 -0.45 1.88e-33 Bipolar disorder; BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.65 14.26 0.49 2.96e-40 Lymphocyte counts; BRCA trans rs208515 0.525 rs12204452 chr6:66680325 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.05 0.54 5.66e-49 Exhaled nitric oxide levels; BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg18402987 chr7:1209562 NA 0.72 12.15 0.43 1.02e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10499694 0.868 rs1470749 chr7:50578023 G/T cg18232548 chr7:50535776 DDC -0.4 -9.48 -0.35 5.09e-20 Body mass index; BRCA cis rs6598955 0.671 rs12354062 chr1:26608761 C/T cg04990556 chr1:26633338 UBXN11 0.55 8.54 0.32 9.88e-17 Obesity-related traits; BRCA cis rs875971 0.660 rs62465434 chr7:66005152 A/C cg11764359 chr7:65958608 NA 0.68 15.19 0.52 9.95e-45 Aortic root size; BRCA cis rs1862618 0.802 rs7733041 chr5:56107377 A/C cg03609598 chr5:56110824 MAP3K1 -0.45 -7.94 -0.3 9.2e-15 Initial pursuit acceleration; BRCA cis rs7666738 0.830 rs11727235 chr4:98946331 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs17685 0.712 rs10952842 chr7:75780413 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 5.04e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9649213 0.574 rs36099592 chr7:98002331 T/C cg21770322 chr7:97807741 LMTK2 0.44 11.54 0.42 4.07e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs7615952 0.576 rs6780025 chr3:125815624 A/C cg05084668 chr3:125655381 ALG1L -0.47 -8.05 -0.3 4.07e-15 Blood pressure (smoking interaction); BRCA cis rs1552244 1.000 rs76041173 chr3:10078695 G/T cg13047869 chr3:10149882 C3orf24 0.59 12.48 0.44 3.79e-32 Alzheimer's disease; BRCA cis rs28830936 1.000 rs17677199 chr15:41954613 C/G cg17847044 chr15:42102381 MAPKBP1 -0.34 -9.64 -0.36 1.27e-20 Diastolic blood pressure; BRCA cis rs2014572 0.967 rs11084492 chr19:57756026 A/T cg24459738 chr19:57751996 ZNF805 -0.33 -7.98 -0.3 6.85e-15 Hyperactive-impulsive symptoms; BRCA cis rs13118159 0.836 rs12647145 chr4:1338618 C/A cg20887711 chr4:1340912 KIAA1530 0.36 8.63 0.32 4.8e-17 Longevity; BRCA cis rs4853012 0.793 rs6707619 chr2:74344656 G/A cg01017244 chr2:74357527 NA 0.57 13.32 0.47 6.89e-36 Gestational age at birth (maternal effect); BRCA cis rs10751667 1.000 rs7396798 chr11:970510 G/T ch.11.42038R chr11:967971 AP2A2 0.58 19.11 0.6 1.02e-64 Alzheimer's disease (late onset); BRCA cis rs9818758 0.607 rs12715434 chr3:49295025 G/C cg00383909 chr3:49044727 WDR6 0.75 13.14 0.46 4.21e-35 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs11098499 0.754 rs878376 chr4:120237702 G/A cg09307838 chr4:120376055 NA 0.62 13.08 0.46 8.24e-35 Corneal astigmatism; BRCA cis rs12971120 0.947 rs3764509 chr18:72167124 C/G cg27029518 chr18:72166324 CNDP2 -0.31 -8.65 -0.32 4.06e-17 Refractive error; BRCA cis rs514406 0.526 rs835608 chr1:53169758 T/A cg16325326 chr1:53192061 ZYG11B -0.77 -19.39 -0.61 3.38e-66 Monocyte count; BRCA cis rs1348850 0.831 rs7606235 chr2:178401288 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.46 9.18 0.34 5.96e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11105298 0.891 rs10858906 chr12:89934474 C/T cg00757033 chr12:89920650 WDR51B 0.52 10.53 0.38 5.15e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs17376456 0.877 rs9885329 chr5:93380278 G/A cg21475434 chr5:93447410 FAM172A 0.7 8.65 0.32 4.16e-17 Diabetic retinopathy; BRCA cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg13175981 chr1:150552382 MCL1 0.37 7.98 0.3 6.76e-15 Blood protein levels; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg08470875 chr2:26401718 FAM59B -0.72 -11.51 -0.41 5.3e-28 Gut microbiome composition (summer); BRCA cis rs35110281 0.811 rs2838339 chr21:45075750 A/G cg01579765 chr21:45077557 HSF2BP 0.43 11.58 0.42 2.83e-28 Mean corpuscular volume; BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg04518342 chr5:131593106 PDLIM4 0.42 10.1 0.37 2.41e-22 Acylcarnitine levels; BRCA trans rs9467711 0.606 rs34104395 chr6:26478252 C/T cg01620082 chr3:125678407 NA -0.7 -8.74 -0.33 2e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs4363385 0.747 rs1999886 chr1:152955522 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.31 -0.31 5.96e-16 Inflammatory skin disease; BRCA cis rs1949733 1.000 rs2631758 chr4:8495304 G/A cg13073564 chr4:8508604 NA 0.44 12.23 0.44 4.53e-31 Response to antineoplastic agents; BRCA trans rs1005277 0.505 rs200910 chr10:38108176 C/T cg17830980 chr10:43048298 ZNF37B -0.41 -9.63 -0.36 1.36e-20 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.728 rs72650852 chr8:58150463 G/A cg11062466 chr8:58055876 NA 0.51 8.81 0.33 1.19e-17 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.565 rs1079177 chr2:219605929 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -11.05 -0.4 4.43e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs1878931 0.513 rs35160989 chr16:3405506 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 0.84 21.23 0.64 4.45e-76 Body mass index (adult); BRCA cis rs965469 0.779 rs2236109 chr20:3286439 C/A cg25506879 chr20:3388711 C20orf194 -0.44 -8.78 -0.33 1.45e-17 IFN-related cytopenia; BRCA cis rs12458462 0.812 rs34583578 chr18:77491070 C/T cg23301140 chr18:77439876 CTDP1 0.35 7.85 0.3 1.82e-14 Monocyte count; BRCA cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg23583168 chr7:148888333 NA -0.83 -18.79 -0.6 4.58e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4742903 0.967 rs7871759 chr9:106865438 A/G cg14250997 chr9:106856677 SMC2 0.35 11.08 0.4 3.32e-26 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.16 0.56 1.47e-54 Bladder cancer; BRCA cis rs250677 0.522 rs4431331 chr5:148353574 A/C cg12140854 chr5:148520817 ABLIM3 -0.39 -7.86 -0.3 1.7e-14 Breast cancer; BRCA cis rs868036 1.000 rs3784719 chr15:68098180 C/T cg05925327 chr15:68127851 NA -0.31 -7.91 -0.3 1.17e-14 Restless legs syndrome; BRCA cis rs10504229 0.683 rs55637580 chr8:58135419 C/T cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs9811920 0.641 rs58704213 chr3:99690331 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -11.09 -0.4 2.87e-26 Axial length; BRCA cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1008375 0.966 rs6837664 chr4:17697835 G/C cg02297831 chr4:17616191 MED28 0.36 8.46 0.32 1.79e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg18230493 chr5:56204884 C5orf35 -0.62 -13.37 -0.47 4.03e-36 Initial pursuit acceleration; BRCA cis rs990171 0.506 rs4141631 chr2:102757216 A/G cg22835712 chr2:102737379 NA 0.58 11.02 0.4 5.7e-26 Lymphocyte counts; BRCA trans rs11098499 0.754 rs7672594 chr4:120248543 A/C cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.38e-23 Corneal astigmatism; BRCA cis rs9311474 0.652 rs352158 chr3:52217704 C/T cg15698299 chr3:52233019 ALAS1 -0.36 -8.21 -0.31 1.22e-15 Electroencephalogram traits; BRCA cis rs12048904 0.512 rs932798 chr1:101249355 G/C cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.7 -15.86 -0.53 5.21e-48 Multiple sclerosis; BRCA cis rs72634258 0.554 rs10462018 chr1:7879627 C/T cg26816564 chr1:7831052 VAMP3 0.64 12.1 0.43 1.78e-30 Inflammatory bowel disease; BRCA cis rs9682041 0.627 rs11917188 chr3:170088607 C/T cg11886554 chr3:170076028 SKIL 0.48 9.78 0.36 3.72e-21 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs1048238 0.846 rs945422 chr1:16345619 T/C cg06159980 chr1:16340746 HSPB7 -0.37 -8.2 -0.31 1.29e-15 Systolic blood pressure; BRCA cis rs4332037 0.552 rs11773627 chr7:2002733 A/G cg23422044 chr7:1970798 MAD1L1 -0.61 -11.71 -0.42 8.22e-29 Bipolar disorder; BRCA cis rs10751667 0.666 rs7395182 chr11:927553 A/C cg01483505 chr11:975446 AP2A2 0.3 8.05 0.3 3.94e-15 Alzheimer's disease (late onset); BRCA cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg21770322 chr7:97807741 LMTK2 0.43 10.98 0.4 7.84e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg09177884 chr7:1199841 ZFAND2A -0.42 -9.02 -0.34 2.15e-18 Longevity;Endometriosis; BRCA cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg26408565 chr15:76604113 ETFA -0.48 -10.32 -0.38 3.51e-23 Blood metabolite levels; BRCA cis rs2072499 1.000 rs2072499 chr1:156169610 A/G cg24450063 chr1:156163899 SLC25A44 1.09 34.81 0.81 1.1e-149 Testicular germ cell tumor; BRCA cis rs11792861 0.619 rs2289480 chr9:111705501 A/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 13.04 0.46 1.26e-34 Menarche (age at onset); BRCA cis rs10504229 1.000 rs17805549 chr8:58179653 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs10267417 0.584 rs10247789 chr7:19863570 G/C cg07541023 chr7:19748670 TWISTNB 0.49 8.97 0.33 3.16e-18 Night sleep phenotypes; BRCA cis rs769267 0.899 rs3934667 chr19:19431423 T/G cg01262667 chr19:19385393 TM6SF2 -0.41 -10.66 -0.39 1.51e-24 Tonsillectomy; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg14789911 chr21:47582049 C21orf56 0.37 7.93 0.3 9.73e-15 Testicular germ cell tumor; BRCA trans rs61931739 0.534 rs1586410 chr12:33999142 C/T cg26384229 chr12:38710491 ALG10B 0.66 13.84 0.48 2.82e-38 Morning vs. evening chronotype; BRCA cis rs6840360 0.550 rs6816471 chr4:152494869 A/G cg22705602 chr4:152727874 NA -0.32 -7.84 -0.3 1.88e-14 Intelligence (multi-trait analysis); BRCA cis rs2580764 0.540 rs2920893 chr2:55270629 C/T cg09592903 chr2:55203963 RTN4 0.38 9.7 0.36 7.68e-21 Mean platelet volume; BRCA cis rs11719291 0.831 rs11715177 chr3:48763894 G/A cg00383909 chr3:49044727 WDR6 0.63 11.36 0.41 2.33e-27 Cognitive function; BRCA cis rs7267979 0.966 rs454723 chr20:25438928 G/C cg08601574 chr20:25228251 PYGB 0.34 8.04 0.3 4.52e-15 Liver enzyme levels (alkaline phosphatase); BRCA trans rs3733585 0.638 rs28715627 chr4:9958140 T/A cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.14e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 1.000 rs880473 chr4:98922596 C/T cg05340658 chr4:99064831 C4orf37 0.59 12.13 0.43 1.28e-30 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg21918786 chr6:109611834 NA -0.49 -14.04 -0.49 3.1e-39 Reticulocyte fraction of red cells; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.7 -14.02 -0.48 4.06e-39 Gut microbiome composition (summer); BRCA cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg06481639 chr22:41940642 POLR3H -0.52 -8.21 -0.31 1.25e-15 Vitiligo; BRCA cis rs6570726 0.846 rs7762536 chr6:145923145 T/C cg23711669 chr6:146136114 FBXO30 0.71 16.54 0.55 1.99e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs4803468 0.967 rs1077856 chr19:41885221 T/C cg09537434 chr19:41945824 ATP5SL -0.96 -23.39 -0.68 6.85e-88 Height; BRCA cis rs2032447 0.507 rs478349 chr6:25894057 T/C cg03517284 chr6:25882590 NA -0.72 -15.4 -0.52 1e-45 Intelligence (multi-trait analysis); BRCA cis rs6815814 0.898 rs73236616 chr4:38789675 G/A cg06935464 chr4:38784597 TLR10 0.51 8.29 0.31 6.7e-16 Breast cancer; BRCA cis rs4862750 0.957 rs4861733 chr4:187903933 C/T cg03452623 chr4:187889614 NA -0.33 -11.08 -0.4 3.22e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg04727924 chr7:799746 HEATR2 -0.54 -9.47 -0.35 5.45e-20 Cerebrospinal P-tau181p levels; BRCA cis rs12618769 0.597 rs3754879 chr2:99164541 G/T cg10123293 chr2:99228465 UNC50 0.44 8.52 0.32 1.11e-16 Bipolar disorder; BRCA cis rs67460515 0.892 rs13059340 chr3:161062631 T/C cg04691961 chr3:161091175 C3orf57 -0.38 -8.02 -0.3 5.16e-15 Parkinson's disease; BRCA cis rs3096299 0.685 rs8050512 chr16:89552320 C/G cg06640241 chr16:89574553 SPG7 0.83 21.25 0.64 3.38e-76 Multiple myeloma (IgH translocation); BRCA cis rs17376456 1.000 rs17376456 chr5:93557702 C/T cg25358565 chr5:93447407 FAM172A -1.2 -18.76 -0.6 6.87e-63 Diabetic retinopathy; BRCA cis rs74181299 0.750 rs13421845 chr2:65336033 G/A cg05010058 chr2:65284262 CEP68 -0.3 -8.26 -0.31 8.36e-16 Pulse pressure; BRCA cis rs3733585 0.673 rs4560411 chr4:9953361 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.35 -0.38 2.61e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg24692254 chr21:30365293 RNF160 -0.46 -10.01 -0.37 5.32e-22 Dental caries; BRCA cis rs7715806 0.500 rs17649332 chr5:75003878 T/C cg19683494 chr5:74908142 NA 0.5 8.1 0.31 2.81e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13217239 0.646 rs4583981 chr6:26992023 G/T cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Schizophrenia; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg13880726 chr7:1868755 MAD1L1 0.42 7.94 0.3 9.02e-15 Bipolar disorder and schizophrenia; BRCA cis rs1997103 0.765 rs55686950 chr7:55396552 A/C cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA trans rs3780486 0.846 rs10116966 chr9:33122370 T/A cg20290983 chr6:43655470 MRPS18A 1.11 40.89 0.85 1.61e-180 IgG glycosylation; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg22907277 chr7:1156413 C7orf50 0.6 9.66 0.36 1.07e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.74 0.42 6.16e-29 Tonsillectomy; BRCA cis rs60871478 0.787 rs4720928 chr7:808002 T/C cg04727924 chr7:799746 HEATR2 -0.54 -10.64 -0.39 1.96e-24 Cerebrospinal P-tau181p levels; BRCA cis rs6964587 0.967 rs34574955 chr7:91847550 A/C cg17063962 chr7:91808500 NA 0.57 13.07 0.46 8.78e-35 Breast cancer; BRCA cis rs7772486 0.790 rs2253768 chr6:146199922 A/G cg13319975 chr6:146136371 FBXO30 -0.44 -10.29 -0.38 4.42e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.806 rs4075696 chr6:146250947 T/C cg23711669 chr6:146136114 FBXO30 -0.67 -15.63 -0.53 7.08e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs875971 0.545 rs1638735 chr7:66095738 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.46 0.38 9.8599999999999993e-24 Aortic root size; BRCA cis rs9814567 1.000 rs3846056 chr3:134227292 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2235642 0.750 rs2974845 chr16:1648162 T/C cg26528668 chr16:1614120 IFT140 0.37 8.28 0.31 7.3e-16 Coronary artery disease; BRCA cis rs7246657 0.943 rs9304566 chr19:37845504 T/C cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg03923535 chr7:1197113 ZFAND2A 0.47 10.29 0.38 4.58e-23 Longevity;Endometriosis; BRCA trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg03929089 chr4:120376271 NA -0.67 -12.99 -0.46 2.19e-34 Coronary artery disease; BRCA cis rs3733585 0.699 rs6449177 chr4:9968050 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -9.95 -0.37 9.02e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7258465 1.000 rs10425982 chr19:18586519 T/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.47 -0.32 1.66e-16 Breast cancer; BRCA cis rs11718455 0.767 rs11708363 chr3:43966585 G/A cg08738300 chr3:44038990 NA 0.5 9.19 0.34 5.41e-19 Coronary artery disease; BRCA cis rs4853036 0.951 rs35344582 chr2:70148093 C/T cg02498382 chr2:70120550 SNRNP27 -0.54 -9.61 -0.36 1.58e-20 Colorectal or endometrial cancer; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg09060608 chr5:178986726 RUFY1 -0.59 -15.74 -0.53 2.05e-47 Lung cancer; BRCA cis rs6582630 0.537 rs1829579 chr12:38420555 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.62 0.39 2.17e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs13191362 0.935 rs34709632 chr6:163048380 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.95 13.93 0.48 1.02e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs6479891 1.000 rs6479899 chr10:65139047 T/A cg14819942 chr15:35414228 NA -0.32 -8.41 -0.32 2.73e-16 Arthritis (juvenile idiopathic); BRCA cis rs2281845 0.507 rs11589642 chr1:201100748 A/G cg06714761 chr1:201096289 NA -0.47 -11.15 -0.4 1.64e-26 Permanent tooth development; BRCA trans rs6951245 1.000 rs11770909 chr7:1086716 G/A cg13565492 chr6:43139072 SRF -0.79 -10.83 -0.39 3.16e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.77 -0.55 1.45e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9393777 0.513 rs9393741 chr6:26654189 A/G cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.89 -0.33 6.32e-18 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg18404041 chr3:52824283 ITIH1 -0.29 -8.13 -0.31 2.24e-15 Electroencephalogram traits; BRCA cis rs6089829 0.962 rs6089825 chr20:61668447 C/T cg08045932 chr20:61659980 NA 0.49 11.3 0.41 4.21e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs13191362 1.000 rs66594243 chr6:163169024 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.61 0.53 8.49e-47 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6815814 0.950 rs5743565 chr4:38805983 T/C cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.48 -0.35 4.8e-20 Endometrial cancer; BRCA cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg00083206 chr6:110721305 DDO -0.39 -9.47 -0.35 5.18e-20 Platelet distribution width; BRCA cis rs724568 0.546 rs966443 chr2:67940867 G/A cg17945962 chr2:67939740 NA -0.39 -10.57 -0.39 3.59e-24 Major depressive disorder (broad); BRCA cis rs56804039 1.000 rs58361948 chr8:8380995 C/T cg06636001 chr8:8085503 FLJ10661 -0.57 -9.31 -0.35 2.02e-19 Cervical cancer; BRCA cis rs7264396 0.733 rs2425105 chr20:34312834 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.22 0.31 1.13e-15 Total cholesterol levels; BRCA cis rs2731664 0.792 rs337374 chr5:176890416 A/G cg23176889 chr5:176863531 GRK6 0.61 16.77 0.55 1.35e-52 Intelligence (multi-trait analysis); BRCA cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 13.53 0.47 7.4e-37 Colorectal cancer; BRCA cis rs796364 0.587 rs7588746 chr2:200986345 A/G cg23649088 chr2:200775458 C2orf69 0.5 8.65 0.32 4.06e-17 Schizophrenia; BRCA cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.57 8.41 0.32 2.78e-16 Cerebrospinal P-tau181p levels; BRCA cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg11266682 chr4:10021025 SLC2A9 0.46 11.95 0.43 7.24e-30 Bone mineral density; BRCA cis rs35306767 0.761 rs12770173 chr10:1027108 A/C cg26597838 chr10:835615 NA 1.02 15.65 0.53 5.92e-47 Eosinophil percentage of granulocytes; BRCA cis rs9287719 0.967 rs10203664 chr2:10752377 T/C cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.88e-23 Prostate cancer; BRCA cis rs68170813 0.559 rs2299422 chr7:106959832 A/T cg02696742 chr7:106810147 HBP1 -0.53 -8.59 -0.32 6.41e-17 Coronary artery disease; BRCA cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg17507749 chr15:85114479 UBE2QP1 -0.55 -10.72 -0.39 8.77e-25 Schizophrenia; BRCA cis rs1577917 0.771 rs6454486 chr6:86433587 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.45 12.88 0.45 6.29e-34 Response to antipsychotic treatment; BRCA cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg24642439 chr20:33292090 TP53INP2 0.71 16.2 0.54 1.06e-49 Coronary artery disease; BRCA cis rs13191362 1.000 rs13202339 chr6:163081812 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.64 10.15 0.37 1.55e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9790314 0.846 rs12495310 chr3:160970956 T/A cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.09e-59 Morning vs. evening chronotype; BRCA cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg21770322 chr7:97807741 LMTK2 0.43 11.35 0.41 2.5e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs34172651 0.517 rs35560136 chr16:24788915 T/A cg06028605 chr16:24865363 SLC5A11 0.4 8.23 0.31 1.03e-15 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg22974920 chr21:40686053 BRWD1 -0.41 -8.93 -0.33 4.5e-18 Cognitive function; BRCA cis rs12579753 1.000 rs10862372 chr12:82249804 C/T cg07988820 chr12:82153109 PPFIA2 -0.62 -10.15 -0.37 1.53e-22 Resting heart rate; BRCA cis rs2204008 0.599 rs2320526 chr12:38220405 T/A cg13010199 chr12:38710504 ALG10B 0.41 8.41 0.32 2.74e-16 Bladder cancer; BRCA cis rs875971 0.545 rs11766183 chr7:65839160 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 10.2 0.37 1.01e-22 Aortic root size; BRCA cis rs6120849 0.754 rs6087666 chr20:33640242 G/A cg24642439 chr20:33292090 TP53INP2 0.6 10.31 0.38 3.78e-23 Protein C levels; BRCA cis rs4563143 0.663 rs73025068 chr19:29238998 G/A cg12667521 chr19:29218732 NA 0.46 8.79 0.33 1.33e-17 Methadone dose in opioid dependence; BRCA cis rs2576037 0.796 rs2576039 chr18:44582148 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.25 0.31 9.04e-16 Personality dimensions; BRCA cis rs2180341 0.960 rs3756996 chr6:127664258 G/C cg27446573 chr6:127587934 RNF146 0.88 20.22 0.62 1.17e-70 Breast cancer; BRCA cis rs6582630 0.555 rs7965311 chr12:38513307 G/A cg13010199 chr12:38710504 ALG10B -0.4 -8.72 -0.33 2.31e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.61 -13.1 -0.46 6.69e-35 Lymphocyte counts; BRCA cis rs2839186 0.770 rs2280956 chr21:47642323 C/G cg13012494 chr21:47604986 C21orf56 -0.43 -8.7 -0.33 2.91e-17 Testicular germ cell tumor; BRCA cis rs4363385 0.747 rs6671414 chr1:152974119 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.33 -0.31 4.8e-16 Inflammatory skin disease; BRCA cis rs17685 0.796 rs3757594 chr7:75678644 G/A cg16489192 chr7:75678113 MDH2;STYXL1 0.41 9.44 0.35 6.94e-20 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs9354352 0.935 rs9354354 chr6:66699333 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.58 -12.83 -0.45 1.1e-33 Initial pursuit acceleration in psychotic disorders; BRCA cis rs7582180 0.629 rs4851298 chr2:100949827 G/A cg14675211 chr2:100938903 LONRF2 0.51 11.68 0.42 1.07e-28 Intelligence (multi-trait analysis); BRCA cis rs7312933 0.558 rs11181466 chr12:42765181 A/T cg01256987 chr12:42539512 GXYLT1 -0.43 -8.28 -0.31 7.25e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.57 -9.71 -0.36 6.91e-21 Gut microbiome composition (summer); BRCA cis rs7949030 0.591 rs12049914 chr11:62369436 C/G cg11742103 chr11:62369870 EML3;MTA2 0.54 13.28 0.47 1.01e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs858239 0.508 rs7805071 chr7:23190212 C/T cg23682824 chr7:23144976 KLHL7 0.37 9.66 0.36 1.11e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs10504229 0.728 rs17215676 chr8:58152915 G/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs9325144 0.560 rs11182930 chr12:38633693 A/T cg26384229 chr12:38710491 ALG10B -0.55 -13.65 -0.48 2.13e-37 Morning vs. evening chronotype; BRCA cis rs6963495 0.872 rs1569134 chr7:105158228 T/C cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs6912958 0.712 rs2246113 chr6:88410050 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.01 -0.3 5.39e-15 Monocyte percentage of white cells; BRCA cis rs11958404 0.932 rs113494689 chr5:157428078 G/T cg05962755 chr5:157440814 NA 0.51 10.01 0.37 5.38e-22 IgG glycosylation; BRCA cis rs2832191 0.791 rs2832181 chr21:30481371 G/T cg08807101 chr21:30365312 RNF160 -0.6 -15.35 -0.52 1.77e-45 Dental caries; BRCA cis rs7829975 0.540 rs2976909 chr8:8346690 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -11.37 -0.41 1.99e-27 Mood instability; BRCA cis rs2180341 0.924 rs6930849 chr6:127630963 A/T cg24812749 chr6:127587940 RNF146 0.89 20.97 0.64 1.08e-74 Breast cancer; BRCA cis rs6910061 0.830 rs58969617 chr6:11110865 C/G cg27233058 chr6:11094804 LOC221710 0.5 8.52 0.32 1.15e-16 Diabetic kidney disease; BRCA trans rs7647973 0.710 rs11130207 chr3:49611666 T/G cg21659725 chr3:3221576 CRBN -0.49 -8.5 -0.32 1.31e-16 Menarche (age at onset); BRCA cis rs2455601 1.000 rs72632952 chr11:8917976 T/C cg21881798 chr11:8931708 C11orf17;ST5 -0.5 -8.43 -0.32 2.24e-16 Schizophrenia; BRCA cis rs7833790 0.963 rs1451997 chr8:82774053 A/T cg27398817 chr8:82754497 SNX16 0.44 8.8 0.33 1.28e-17 Diastolic blood pressure; BRCA cis rs763014 0.966 rs35642938 chr16:642249 T/C cg04709771 chr16:646395 RAB40C 0.45 11.43 0.41 1.22e-27 Height; BRCA cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg25767906 chr1:53392781 SCP2 0.37 8.6 0.32 6.07e-17 Monocyte count; BRCA cis rs2073300 1.000 rs6137967 chr20:23447108 A/T cg12062639 chr20:23401060 NAPB -0.58 -8.24 -0.31 9.85e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg14343924 chr8:8086146 FLJ10661 0.41 8.49 0.32 1.41e-16 Mood instability; BRCA trans rs8002861 0.935 rs7320988 chr13:44413523 C/T cg17145862 chr1:211918768 LPGAT1 0.68 17.75 0.57 1.37e-57 Leprosy; BRCA cis rs7246657 0.943 rs10414904 chr19:37830088 G/A cg18154014 chr19:37997991 ZNF793 0.49 9.55 0.35 2.63e-20 Coronary artery calcification; BRCA cis rs4285028 0.948 rs2091664 chr3:121684749 T/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -11.01 -0.4 6.18e-26 Multiple sclerosis; BRCA cis rs13102973 0.899 rs13122646 chr4:135906123 T/C cg14419869 chr4:135874104 NA 0.45 8.99 0.34 2.75e-18 Subjective well-being; BRCA cis rs754466 0.580 rs10824575 chr10:79549047 A/G cg17075019 chr10:79541650 NA -0.88 -23.78 -0.69 5.35e-90 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs12541635 1.000 rs1366969 chr8:107092851 A/T cg10147462 chr8:107024639 NA -0.3 -8.2 -0.31 1.29e-15 Age of smoking initiation; BRCA trans rs877282 0.945 rs11253388 chr10:787852 A/G cg22713356 chr15:30763199 NA 1.42 28.54 0.75 3.84e-116 Uric acid levels; BRCA cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg16989086 chr20:62203971 PRIC285 0.52 8.89 0.33 6.31e-18 Glioblastoma; BRCA cis rs858239 0.536 rs6961109 chr7:23252413 C/T cg23682824 chr7:23144976 KLHL7 0.32 8.34 0.31 4.44e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs992157 0.804 rs6758540 chr2:219138625 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.5 -10.61 -0.39 2.51e-24 Colorectal cancer; BRCA trans rs3960554 0.673 rs57358338 chr7:75732923 T/C cg19862616 chr7:65841803 NCRNA00174 0.57 12.16 0.43 9.08e-31 Eotaxin levels; BRCA trans rs7615952 0.576 rs4646748 chr3:125826329 G/A cg07211511 chr3:129823064 LOC729375 -0.63 -11.13 -0.4 1.99e-26 Blood pressure (smoking interaction); BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg02951883 chr7:2050386 MAD1L1 -0.53 -11.38 -0.41 1.83e-27 Bipolar disorder and schizophrenia; BRCA cis rs61931739 0.534 rs11052957 chr12:33995354 G/A cg06521331 chr12:34319734 NA -0.53 -10.61 -0.39 2.4e-24 Morning vs. evening chronotype; BRCA cis rs7617773 0.963 rs6766754 chr3:48182589 T/C cg11946769 chr3:48343235 NME6 -0.41 -9.07 -0.34 1.49e-18 Coronary artery disease; BRCA cis rs3741404 0.620 rs882147 chr11:63976689 T/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.65 0.5 4.04e-42 Platelet count; BRCA cis rs8180040 0.593 rs10433549 chr3:47031433 C/T cg16586182 chr3:47516702 SCAP 0.51 11.21 0.41 9.89e-27 Colorectal cancer; BRCA cis rs1865760 0.566 rs3752420 chr6:26027135 G/A cg16482183 chr6:26056742 HIST1H1C 0.55 11.7 0.42 8.82e-29 Height; BRCA cis rs6831352 0.918 rs29001201 chr4:100053861 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.73 -0.36 5.88e-21 Alcohol dependence; BRCA trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg15704280 chr7:45808275 SEPT13 -0.47 -9.07 -0.34 1.41e-18 Height; BRCA cis rs17799476 1.000 rs17799476 chr2:46352326 C/G cg12428440 chr2:46370979 PRKCE 0.49 8.71 0.33 2.63e-17 Hemoglobin concentration;Hematocrit; BRCA cis rs425277 0.628 rs262668 chr1:2082602 A/G cg04315214 chr1:2043799 PRKCZ -0.48 -12.62 -0.45 9.65e-33 Height; BRCA cis rs28374715 0.681 rs11629979 chr15:41626579 A/G cg18705301 chr15:41695430 NDUFAF1 -0.81 -19.01 -0.6 3.23e-64 Ulcerative colitis; BRCA trans rs3780486 0.846 rs10758192 chr9:33131651 G/A cg20290983 chr6:43655470 MRPS18A 1.1 41.39 0.85 5.5e-183 IgG glycosylation; BRCA cis rs8062405 1.000 rs4788102 chr16:28873398 G/A cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.66 -12.01 -0.43 4.19e-30 Gut microbiome composition (summer); BRCA cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg24642439 chr20:33292090 TP53INP2 0.52 11.43 0.41 1.2e-27 Glomerular filtration rate (creatinine); BRCA cis rs3749237 1.000 rs11920900 chr3:49823024 G/C cg03060546 chr3:49711283 APEH 0.52 10.85 0.39 2.8e-25 Resting heart rate; BRCA cis rs6570726 0.791 rs11759979 chr6:145918881 C/T cg23711669 chr6:146136114 FBXO30 0.78 18.5 0.59 1.6e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs11112613 0.713 rs11112592 chr12:105951702 C/T cg03607813 chr12:105948248 NA -0.55 -10.65 -0.39 1.75e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs10465746 0.780 rs1570691 chr1:84370393 A/C cg10977910 chr1:84465055 TTLL7 0.55 11.46 0.41 8.86e-28 Obesity-related traits; BRCA cis rs9868809 0.881 rs13063312 chr3:48661985 G/A cg00383909 chr3:49044727 WDR6 0.53 8.03 0.3 4.61e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg00531865 chr16:30841666 NA -0.38 -9.06 -0.34 1.62e-18 Dementia with Lewy bodies; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -13.04 -0.46 1.22e-34 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6582630 0.502 rs1915395 chr12:38420726 A/G cg26384229 chr12:38710491 ALG10B 0.77 17.62 0.57 6.36e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs4409675 0.576 rs7535816 chr1:28234054 A/G cg23691781 chr1:28212827 C1orf38 0.32 10.79 0.39 4.97e-25 Corneal astigmatism; BRCA cis rs3733585 0.699 rs10017674 chr4:9967053 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.21e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2204008 0.774 rs8186954 chr12:38318566 C/A cg26384229 chr12:38710491 ALG10B 0.69 16.17 0.54 1.53e-49 Bladder cancer; BRCA cis rs6951245 0.678 rs28600085 chr7:1169636 C/T cg22907277 chr7:1156413 C7orf50 0.62 10.77 0.39 5.48e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs17092148 1.000 rs3787223 chr20:33331385 C/T cg16810054 chr20:33298113 TP53INP2 0.49 11.18 0.4 1.23e-26 Neuroticism; BRCA cis rs61931739 0.500 rs7955933 chr12:34473608 A/G cg06521331 chr12:34319734 NA -0.5 -9.58 -0.35 2.09e-20 Morning vs. evening chronotype; BRCA cis rs3820928 0.874 rs4675137 chr2:227883910 G/C cg11843606 chr2:227700838 RHBDD1 -0.36 -7.89 -0.3 1.28e-14 Pulmonary function; BRCA cis rs7811142 1.000 rs7809801 chr7:100072031 T/C cg11814155 chr7:99998594 ZCWPW1 0.44 8.32 0.31 5.27e-16 Platelet count; BRCA cis rs1862618 0.713 rs832549 chr5:56183542 C/T cg24531977 chr5:56204891 C5orf35 -0.86 -17.8 -0.58 7.44e-58 Initial pursuit acceleration; BRCA cis rs6545883 0.868 rs2518932 chr2:61801277 T/A cg15711740 chr2:61764176 XPO1 -0.54 -13.73 -0.48 9.31e-38 Tuberculosis; BRCA trans rs1941687 0.563 rs7238931 chr18:31334993 G/A cg27147174 chr7:100797783 AP1S1 -0.46 -8.93 -0.33 4.4e-18 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs6430585 0.583 rs7581814 chr2:136641593 C/G cg07169764 chr2:136633963 MCM6 -1.26 -28.52 -0.75 5.08e-116 Corneal structure; BRCA cis rs2153535 0.580 rs2327060 chr6:8447111 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.49 0.35 4.56e-20 Motion sickness; BRCA cis rs514406 0.505 rs269293 chr1:53187767 A/C cg16325326 chr1:53192061 ZYG11B 0.93 25.57 0.71 7.65e-100 Monocyte count; BRCA cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg06618935 chr21:46677482 NA -0.35 -7.81 -0.3 2.32e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs798554 0.660 rs798480 chr7:2805597 G/T cg18446336 chr7:2847575 GNA12 -0.35 -7.91 -0.3 1.1e-14 Height; BRCA cis rs68170813 0.523 rs11766131 chr7:107071138 T/C cg02696742 chr7:106810147 HBP1 -0.52 -8.18 -0.31 1.58e-15 Coronary artery disease; BRCA cis rs6570726 0.791 rs9497357 chr6:145912888 G/A cg05347473 chr6:146136440 FBXO30 0.41 8.38 0.31 3.49e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs2174743 chr6:79591805 G/A cg18132916 chr6:79620363 NA -0.48 -10.82 -0.39 3.74e-25 Intelligence (multi-trait analysis); BRCA trans rs3960554 0.932 rs76873475 chr7:75829199 C/A cg19862616 chr7:65841803 NCRNA00174 0.59 12.0 0.43 4.67e-30 Eotaxin levels; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs495337 1.000 rs632376 chr20:48520610 A/G cg17835207 chr20:48524531 SPATA2 -0.55 -11.83 -0.42 2.46e-29 Psoriasis; BRCA cis rs1577917 0.958 rs12192546 chr6:86476484 A/G cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.39 9.47 0.35 5.42e-20 Response to antipsychotic treatment; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg27588902 chr6:42928151 GNMT -0.31 -10.31 -0.38 3.85e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9311474 0.935 rs7622851 chr3:52333671 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.26 7.87 0.3 1.56e-14 Electroencephalogram traits; BRCA cis rs2559856 0.967 rs2695297 chr12:102082218 T/C cg12924262 chr12:102091054 CHPT1 0.36 8.13 0.31 2.22e-15 Blood protein levels; BRCA cis rs769267 0.930 rs10402451 chr19:19608537 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.46 9.25 0.34 3.3e-19 Tonsillectomy; BRCA cis rs921968 0.541 rs485975 chr2:219374250 C/T cg02176678 chr2:219576539 TTLL4 0.46 11.78 0.42 4.07e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs61931739 0.500 rs11053213 chr12:34466395 G/T cg06521331 chr12:34319734 NA -0.56 -9.91 -0.37 1.24e-21 Morning vs. evening chronotype; BRCA trans rs61931739 0.853 rs11053002 chr12:34083499 T/C cg26384229 chr12:38710491 ALG10B -0.41 -9.61 -0.36 1.68e-20 Morning vs. evening chronotype; BRCA cis rs2066819 1.000 rs2291361 chr12:56717805 G/A cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg16339924 chr4:17578868 LAP3 0.66 16.94 0.56 2.01e-53 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2153535 0.601 rs9393030 chr6:8516489 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.53 0.38 5.1900000000000004e-24 Motion sickness; BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9649213 0.574 rs6979373 chr7:97961844 T/C cg21770322 chr7:97807741 LMTK2 0.42 11.06 0.4 3.78e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs9649213 0.593 rs55825602 chr7:98013039 T/C cg24562669 chr7:97807699 LMTK2 0.45 12.05 0.43 2.92e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs73242632 1.000 rs2227902 chr4:57797100 G/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.65 7.81 0.3 2.38e-14 Congenital heart disease (maternal effect); BRCA cis rs7586879 0.789 rs17046737 chr2:25127835 C/T cg01884057 chr2:25150051 NA 0.31 7.83 0.3 2.11e-14 Body mass index; BRCA cis rs7481584 0.624 rs80871 chr11:3049843 A/C cg08508325 chr11:3079039 CARS 0.28 8.45 0.32 2e-16 Calcium levels; BRCA cis rs870825 0.860 rs72703529 chr4:185607351 T/C cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs9649213 0.593 rs6947340 chr7:97912241 A/G cg01877450 chr7:97915802 BRI3 0.35 8.24 0.31 9.73e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs858239 0.539 rs6949363 chr7:23192394 A/G cg23682824 chr7:23144976 KLHL7 0.41 10.89 0.4 1.84e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs10256972 0.591 rs6950319 chr7:1161324 A/G cg23978390 chr7:1156363 C7orf50 0.5 11.92 0.43 1.04e-29 Longevity;Endometriosis; BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg09877947 chr5:131593287 PDLIM4 0.42 10.65 0.39 1.65e-24 Breast cancer; BRCA cis rs17253792 0.822 rs75437558 chr14:56066798 C/T cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs1506636 1.000 rs656425 chr7:123424525 A/C cg03229431 chr7:123269106 ASB15 0.61 13.54 0.47 6.54e-37 Plateletcrit;Platelet count; BRCA cis rs67478160 0.643 rs8003653 chr14:104298836 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.58 -0.32 7.26e-17 Schizophrenia; BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg27170947 chr2:26402098 FAM59B 0.98 17.0 0.56 9.48e-54 Gut microbiome composition (summer); BRCA cis rs3806843 0.868 rs2531342 chr5:140130612 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.27 0.34 2.84e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.39 8.02 0.3 5.09e-15 Personality dimensions; BRCA cis rs2180341 1.000 rs2057223 chr6:127637374 T/C cg24812749 chr6:127587940 RNF146 0.88 20.74 0.63 1.82e-73 Breast cancer; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.51 8.26 0.31 8.15e-16 Renal function-related traits (BUN); BRCA cis rs3733585 0.673 rs7375587 chr4:9954758 A/T cg11266682 chr4:10021025 SLC2A9 0.4 10.6 0.39 2.76e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs317689 0.513 rs317659 chr12:69686132 T/A cg14784868 chr12:69753453 YEATS4 0.48 11.18 0.4 1.28e-26 Response to diuretic therapy; BRCA cis rs10754283 0.967 rs12058749 chr1:90105604 C/T cg21401794 chr1:90099060 LRRC8C 0.49 11.38 0.41 1.87e-27 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg11598736 chr3:195384522 SDHAP2 0.68 11.81 0.42 3.09e-29 Lung disease severity in cystic fibrosis; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg23708337 chr7:1209742 NA 0.63 8.88 0.33 6.66e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9291683 0.526 rs6827785 chr4:10018205 C/T cg02734326 chr4:10020555 SLC2A9 0.36 7.96 0.3 7.66e-15 Bone mineral density; BRCA cis rs7178424 1.000 rs7162536 chr15:62373459 A/C cg00456672 chr15:62358751 C2CD4A -0.35 -8.46 -0.32 1.81e-16 Height; BRCA cis rs8028182 0.636 rs4886703 chr15:75730366 C/T cg20655648 chr15:75932815 IMP3 0.4 7.81 0.3 2.38e-14 Sudden cardiac arrest; BRCA cis rs1577917 0.917 rs2218594 chr6:86543766 A/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.43 -0.41 1.14e-27 Response to antipsychotic treatment; BRCA cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg04553112 chr3:125709451 NA -0.56 -8.41 -0.32 2.61e-16 Blood pressure (smoking interaction); BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg08219700 chr8:58056026 NA -0.56 -9.07 -0.34 1.41e-18 Developmental language disorder (linguistic errors); BRCA cis rs5758511 0.689 rs56906457 chr22:42628335 A/G cg00645731 chr22:42541494 CYP2D7P1 0.57 9.37 0.35 1.23e-19 Birth weight; BRCA cis rs6570726 0.791 rs441290 chr6:145883183 A/G cg23711669 chr6:146136114 FBXO30 0.71 16.91 0.56 2.63e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs61931739 0.500 rs11053246 chr12:34516620 C/T cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA trans rs1005277 0.589 rs2749624 chr10:38529865 A/G cg17830980 chr10:43048298 ZNF37B -0.52 -12.54 -0.44 2.01e-32 Extrinsic epigenetic age acceleration; BRCA cis rs9467773 1.000 rs1078679 chr6:26568741 C/T cg11502198 chr6:26597334 ABT1 0.49 9.73 0.36 5.8e-21 Intelligence (multi-trait analysis); BRCA cis rs7917772 0.536 rs12357172 chr10:104388549 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 16.31 0.54 3.1e-50 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs483180 0.532 rs561931 chr1:120254506 A/G cg19096424 chr1:120255104 PHGDH 0.47 11.02 0.4 5.44e-26 Macular telangiectasia type 2; BRCA cis rs2242116 0.796 rs7645278 chr3:46974100 A/C cg02527881 chr3:46936655 PTH1R -0.34 -8.16 -0.31 1.77e-15 Birth weight; BRCA cis rs17270561 0.609 rs4712970 chr6:25770707 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.64 0.36 1.24e-20 Iron status biomarkers; BRCA cis rs9880211 0.800 rs9813376 chr3:136475426 C/T cg21827317 chr3:136751795 NA -0.45 -7.87 -0.3 1.47e-14 Body mass index;Height; BRCA cis rs6973256 0.862 rs11762935 chr7:133327950 G/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.85 -0.33 8.22e-18 Intelligence (multi-trait analysis); BRCA cis rs1448094 0.512 rs4362214 chr12:86245145 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.28 -0.34 2.49e-19 Major depressive disorder; BRCA cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg11952622 chr19:58962976 ZNF324B 0.44 9.02 0.34 2.15e-18 Uric acid clearance; BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg18538332 chr22:24372958 LOC391322 0.44 9.46 0.35 5.67e-20 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs9682041 0.877 rs6804688 chr3:170071191 T/G cg11886554 chr3:170076028 SKIL 0.52 10.71 0.39 1.03e-24 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg26031613 chr14:104095156 KLC1 -0.52 -9.32 -0.35 1.9e-19 Reticulocyte count; BRCA cis rs1801251 0.644 rs283473 chr2:233654847 A/G cg08000102 chr2:233561755 GIGYF2 0.64 14.67 0.5 3.27e-42 Coronary artery disease; BRCA cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11644478 chr21:40555479 PSMG1 0.85 19.85 0.62 1.1e-68 Cognitive function; BRCA cis rs8177253 0.665 rs4525863 chr3:133436136 C/A cg01448562 chr3:133502909 NA -0.43 -9.38 -0.35 1.17e-19 Iron status biomarkers; BRCA trans rs1005277 0.579 rs2505257 chr10:38372664 A/G cg23533926 chr12:111358616 MYL2 -0.4 -8.34 -0.31 4.7e-16 Extrinsic epigenetic age acceleration; BRCA cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg00149659 chr3:10157352 C3orf10 0.79 13.83 0.48 3.03e-38 Alzheimer's disease; BRCA cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.4 -8.38 -0.31 3.27e-16 Aortic root size; BRCA cis rs3806843 0.966 rs3756338 chr5:140180561 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.83 -0.36 2.54e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs931812 0.757 rs13251801 chr8:101902629 A/T cg20993868 chr7:22813445 NA 0.45 13.71 0.48 1.06e-37 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs11122272 0.735 rs2790880 chr1:231534259 C/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -11.58 -0.42 2.69e-28 Hemoglobin concentration; BRCA cis rs8028182 0.636 rs8028277 chr15:75684085 A/G cg20655648 chr15:75932815 IMP3 0.4 7.85 0.3 1.73e-14 Sudden cardiac arrest; BRCA cis rs61931739 0.500 rs10844848 chr12:34409705 A/C cg06521331 chr12:34319734 NA -0.56 -10.01 -0.37 5.41e-22 Morning vs. evening chronotype; BRCA cis rs12142240 0.698 rs1984490 chr1:46858734 C/T cg10495392 chr1:46806563 NSUN4 -0.45 -8.38 -0.31 3.26e-16 Menopause (age at onset); BRCA cis rs7666738 0.791 rs10033211 chr4:98995624 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs8028182 0.636 rs28623700 chr15:75849714 T/A cg20655648 chr15:75932815 IMP3 0.44 8.7 0.33 2.74e-17 Sudden cardiac arrest; BRCA cis rs2836950 0.501 rs11702505 chr21:40700614 G/T cg11890956 chr21:40555474 PSMG1 -0.61 -13.36 -0.47 4.64e-36 Menarche (age at onset); BRCA cis rs10782582 0.593 rs6664254 chr1:76235084 G/T cg03433033 chr1:76189801 ACADM -0.47 -9.49 -0.35 4.43e-20 Daytime sleep phenotypes; BRCA cis rs769267 0.501 rs2965187 chr19:19522970 T/A cg11584989 chr19:19387371 SF4 0.48 10.8 0.39 4.46e-25 Tonsillectomy; BRCA cis rs12612619 0.732 rs13032059 chr2:27233789 T/C cg00617064 chr2:27272375 NA -0.3 -7.97 -0.3 7.44e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7786808 0.776 rs11983316 chr7:158209742 A/G cg09998033 chr7:158218633 PTPRN2 -0.33 -7.81 -0.3 2.32e-14 Obesity-related traits; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs2836950 0.501 rs13047518 chr21:40707307 G/A cg17971929 chr21:40555470 PSMG1 -0.45 -9.84 -0.36 2.34e-21 Menarche (age at onset); BRCA cis rs791888 0.858 rs1555434 chr10:89419143 G/C cg13926569 chr10:89418898 PAPSS2 -0.35 -8.11 -0.31 2.6e-15 Magnesium levels; BRCA cis rs2073300 0.609 rs6137910 chr20:23346515 C/G cg12062639 chr20:23401060 NAPB 0.94 13.44 0.47 1.85e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4302748 0.862 rs12530870 chr7:36181501 A/G cg24442661 chr7:36192818 EEPD1 0.44 8.28 0.31 7.31e-16 Platelet count; BRCA cis rs1005224 0.889 rs12717566 chr14:76147507 C/T cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.11 -0.31 2.65e-15 Large artery stroke; BRCA cis rs4713118 0.513 rs156738 chr6:28014025 G/C cg10876282 chr6:28092338 ZSCAN16 0.41 7.89 0.3 1.32e-14 Parkinson's disease; BRCA cis rs2011503 0.941 rs2010506 chr19:19387356 C/T cg11584989 chr19:19387371 SF4 0.67 14.72 0.5 1.86e-42 Bipolar disorder; BRCA cis rs6547741 0.935 rs56001553 chr2:27859926 C/T cg27432699 chr2:27873401 GPN1 -0.42 -8.61 -0.32 5.5e-17 Oral cavity cancer; BRCA cis rs9287719 0.967 rs11687023 chr2:10741412 G/A cg00105475 chr2:10696890 NA 0.44 10.37 0.38 2.16e-23 Prostate cancer; BRCA cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.54e-19 Motion sickness; BRCA cis rs6088580 0.634 rs9789792 chr20:32957709 G/A cg08999081 chr20:33150536 PIGU -0.46 -12.55 -0.44 1.89e-32 Glomerular filtration rate (creatinine); BRCA cis rs12950390 0.853 rs56363619 chr17:45854621 T/C cg24803719 chr17:45855879 NA -0.31 -8.32 -0.31 5.29e-16 IgG glycosylation; BRCA cis rs6840360 0.593 rs867800 chr4:152691470 T/C cg22705602 chr4:152727874 NA -0.39 -10.64 -0.39 1.94e-24 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg27170947 chr2:26402098 FAM59B -0.66 -11.39 -0.41 1.75e-27 Gut microbiome composition (summer); BRCA cis rs709400 0.663 rs3742458 chr14:103950368 A/G cg24130564 chr14:104152367 KLC1 -0.34 -8.04 -0.3 4.46e-15 Body mass index; BRCA cis rs7552404 0.727 rs61770533 chr1:76306490 C/G cg22875332 chr1:76189707 ACADM 0.64 12.06 0.43 2.44e-30 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6938 0.575 rs12902515 chr15:75160998 G/C cg10253484 chr15:75165896 SCAMP2 -0.56 -11.56 -0.42 3.36e-28 Breast cancer; BRCA cis rs490234 0.702 rs13302549 chr9:128284775 T/C cg14078157 chr9:128172775 NA -0.51 -11.38 -0.41 1.89e-27 Mean arterial pressure; BRCA cis rs4808199 0.948 rs2301668 chr19:19452249 G/A cg03709012 chr19:19516395 GATAD2A 1.0 18.63 0.59 3.29e-62 Nonalcoholic fatty liver disease; BRCA cis rs34779708 0.966 rs10827491 chr10:35427395 G/A cg03585969 chr10:35415529 CREM 0.49 10.22 0.37 8.41e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13064411 0.735 rs7636128 chr3:113133701 A/T cg18753928 chr3:113234510 CCDC52 -0.42 -8.19 -0.31 1.46e-15 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7618915 0.547 rs2878726 chr3:52748271 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.92 0.4 1.42e-25 Bipolar disorder; BRCA cis rs7618915 0.547 rs10780035 chr3:52764624 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.8 0.39 4.48e-25 Bipolar disorder; BRCA cis rs9463078 0.683 rs911524 chr6:44747204 G/A cg25276700 chr6:44698697 NA 0.36 8.08 0.3 3.32e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1371614 0.552 rs35538505 chr2:27126027 G/T cg12368169 chr2:27073192 DPYSL5 -0.29 -8.31 -0.31 5.69e-16 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2806561 0.664 rs55764475 chr1:23318983 C/T cg19743168 chr1:23544995 NA 0.34 7.97 0.3 7.51e-15 Height; BRCA cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg04450456 chr4:17643702 FAM184B 0.38 11.19 0.4 1.12e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11792861 0.926 rs7870597 chr9:111871864 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.17 0.31 1.71e-15 Menarche (age at onset); BRCA cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg04455712 chr21:45112962 RRP1B 0.44 11.34 0.41 2.64e-27 Mean corpuscular volume; BRCA cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg01579765 chr21:45077557 HSF2BP -0.36 -9.9 -0.36 1.36e-21 Mean corpuscular volume; BRCA trans rs4942242 1.000 rs9533572 chr13:44234265 A/C cg19169023 chr15:41853346 TYRO3 -0.52 -11.66 -0.42 1.29e-28 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs798554 0.797 rs798487 chr7:2802943 G/A cg19346786 chr7:2764209 NA -0.33 -9.81 -0.36 2.93e-21 Height; BRCA cis rs7520050 0.807 rs4468203 chr1:46113272 T/C cg24296786 chr1:45957014 TESK2 -0.46 -10.64 -0.39 1.87e-24 Red blood cell count;Reticulocyte count; BRCA cis rs2742234 0.955 rs2435385 chr10:43665750 A/G cg15436174 chr10:43711423 RASGEF1A -0.44 -9.13 -0.34 8.96e-19 Hirschsprung disease; BRCA cis rs6815814 0.861 rs1135430 chr4:38789361 T/C cg06935464 chr4:38784597 TLR10 0.47 9.07 0.34 1.5e-18 Breast cancer; BRCA cis rs3793683 0.965 rs3829131 chr10:134564627 A/G cg18305652 chr10:134549665 INPP5A -0.3 -8.47 -0.32 1.67e-16 Migraine; BRCA cis rs10504229 0.724 rs72650827 chr8:58126884 A/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs9814567 0.727 rs4245908 chr3:134349205 A/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.51 -15.99 -0.53 1.17e-48 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9325144 0.560 rs1843911 chr12:38676585 C/T cg26384229 chr12:38710491 ALG10B -0.52 -13.51 -0.47 9.34e-37 Morning vs. evening chronotype; BRCA trans rs1005277 0.579 rs2474584 chr10:38416389 C/T cg17830980 chr10:43048298 ZNF37B -0.57 -14.16 -0.49 8.76e-40 Extrinsic epigenetic age acceleration; BRCA cis rs9549367 0.789 rs71446682 chr13:113894908 A/G cg18105134 chr13:113819100 PROZ -0.63 -14.24 -0.49 3.69e-40 Platelet distribution width; BRCA cis rs9467711 0.591 rs13192365 chr6:25993968 T/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.24 0.34 3.63e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs3767633 0.925 rs4233380 chr1:161892483 A/C cg09175582 chr1:161736000 ATF6 0.55 8.92 0.33 4.71e-18 IgG glycosylation; BRCA cis rs8177253 0.829 rs9813689 chr3:133514822 C/T cg08048268 chr3:133502702 NA -0.42 -10.42 -0.38 1.35e-23 Iron status biomarkers; BRCA cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg14004847 chr7:1930337 MAD1L1 0.41 8.53 0.32 1.06e-16 Schizophrenia; BRCA cis rs2153535 0.601 rs9502719 chr6:8541032 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.64 0.32 4.65e-17 Motion sickness; BRCA cis rs1005277 0.579 rs1740742 chr10:38518860 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -18.16 -0.58 1.03e-59 Extrinsic epigenetic age acceleration; BRCA cis rs9487051 0.768 rs445796 chr6:109520145 T/C cg21918786 chr6:109611834 NA -0.34 -9.15 -0.34 7.85e-19 Reticulocyte fraction of red cells; BRCA cis rs10504073 0.669 rs341802 chr8:50039313 C/T cg00325661 chr8:49890786 NA 0.37 10.57 0.39 3.64e-24 Blood metabolite ratios; BRCA cis rs2153535 0.563 rs7739249 chr6:8534590 C/G cg23788917 chr6:8435910 SLC35B3 0.48 10.52 0.38 5.57e-24 Motion sickness; BRCA cis rs4363385 0.791 rs4041401 chr1:152985629 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.04 -0.34 1.83e-18 Inflammatory skin disease; BRCA cis rs586533 0.781 rs639161 chr11:99495147 G/A cg22878054 chr11:99397252 CNTN5 0.32 8.03 0.3 4.67e-15 Depressive symptoms (multi-trait analysis); BRCA trans rs877282 0.945 rs71491303 chr10:772884 G/T cg22713356 chr15:30763199 NA 1.19 24.18 0.69 3.39e-92 Uric acid levels; BRCA cis rs7100689 0.646 rs7899791 chr10:82091950 A/T cg01528321 chr10:82214614 TSPAN14 0.81 17.34 0.57 1.76e-55 Post bronchodilator FEV1; BRCA cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg03517284 chr6:25882590 NA -0.47 -9.52 -0.35 3.47e-20 Intelligence (multi-trait analysis); BRCA cis rs12579753 1.000 rs11115047 chr12:82232773 C/G cg07988820 chr12:82153109 PPFIA2 -0.65 -10.43 -0.38 1.32e-23 Resting heart rate; BRCA trans rs9291683 0.517 rs11736479 chr4:10017387 G/C cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.34e-16 Bone mineral density; BRCA cis rs4561483 0.801 rs40311 chr16:11963190 C/G cg08843971 chr16:11963173 GSPT1 0.53 11.72 0.42 7.27e-29 Testicular germ cell tumor; BRCA trans rs11165623 0.792 rs6593599 chr1:96911468 C/T cg10631902 chr5:14652156 NA -0.51 -16.13 -0.54 2.38e-49 Hip circumference;Waist circumference; BRCA cis rs6879260 1.000 rs6874653 chr5:179730843 A/G cg23221052 chr5:179740743 GFPT2 -0.67 -14.07 -0.49 2.4e-39 Height; BRCA cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg27015174 chr15:43622946 ADAL;LCMT2 0.53 10.21 0.37 8.8e-23 Lung cancer in ever smokers; BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs10736390 1.000 rs10736390 chr1:55103945 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.6 -14.49 -0.5 2.5e-41 Survival in pancreatic cancer; BRCA cis rs400736 0.602 rs6694154 chr1:8163520 G/A cg25007680 chr1:8021821 PARK7 -0.35 -8.59 -0.32 6.88e-17 Response to antidepressants and depression; BRCA cis rs6952808 0.862 rs4721135 chr7:1912222 A/G cg05863683 chr7:1912471 MAD1L1 0.38 8.41 0.32 2.73e-16 Bipolar disorder and schizophrenia; BRCA cis rs9859260 0.710 rs366268 chr3:195782177 A/G cg03462622 chr3:195777018 TFRC -0.38 -8.61 -0.32 5.5e-17 Mean corpuscular volume; BRCA cis rs34779708 0.966 rs12773647 chr10:35440327 A/G cg03585969 chr10:35415529 CREM 0.55 11.41 0.41 1.39e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10504229 1.000 rs58382845 chr8:58169851 A/C cg14926445 chr8:58193284 C8orf71 -0.46 -8.7 -0.33 2.73e-17 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.68 0.5 2.94e-42 Motion sickness; BRCA cis rs2279817 1.000 rs2279815 chr1:18022066 G/T cg21791023 chr1:18019539 ARHGEF10L 0.54 16.01 0.54 9.3e-49 Neuroticism; BRCA cis rs897080 0.552 rs1067389 chr2:44642290 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.45 0.35 6.32e-20 Height; BRCA trans rs9409565 0.826 rs2139189 chr9:97238538 A/G cg05679027 chr9:99775184 HIATL2 -0.42 -9.34 -0.35 1.62e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs1865760 0.613 rs7749342 chr6:25920265 T/C cg12310025 chr6:25882481 NA -0.42 -9.97 -0.37 7.67e-22 Height; BRCA cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg13319975 chr6:146136371 FBXO30 -0.43 -10.05 -0.37 3.67e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs477895 0.653 rs2015226 chr11:63902534 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 8.62 0.32 5.17e-17 Mean platelet volume; BRCA cis rs8044868 0.586 rs6499557 chr16:72082654 A/G cg16558253 chr16:72132732 DHX38 -0.45 -10.76 -0.39 6.27e-25 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs736408 0.509 rs1108842 chr3:52720080 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 9.15 0.34 7.27e-19 Bipolar disorder; BRCA cis rs1555322 0.530 rs7004 chr20:33866753 G/C cg03689076 chr20:33865952 NA 0.47 8.5 0.32 1.34e-16 Attention deficit hyperactivity disorder; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg18301423 chr5:131593218 PDLIM4 0.35 8.75 0.33 1.93e-17 Acylcarnitine levels; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg09877947 chr5:131593287 PDLIM4 0.46 11.17 0.4 1.37e-26 Acylcarnitine levels; BRCA cis rs9487051 0.768 rs442405 chr6:109526980 T/G cg01475377 chr6:109611718 NA -0.41 -10.29 -0.38 4.49e-23 Reticulocyte fraction of red cells; BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA trans rs11098499 0.738 rs34566984 chr4:120361270 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.92 0.46 4.23e-34 Corneal astigmatism; BRCA trans rs11088226 0.581 rs2833856 chr21:33877691 A/G cg09050820 chr6:167586206 TCP10L2 -0.39 -8.03 -0.3 4.63e-15 Gastritis; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg03352830 chr11:487213 PTDSS2 0.86 12.96 0.46 2.94e-34 Body mass index; BRCA cis rs501916 0.833 rs11855134 chr15:48047676 A/G cg16110827 chr15:48056943 SEMA6D -0.43 -9.06 -0.34 1.57e-18 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg21782813 chr7:2030301 MAD1L1 0.39 11.45 0.41 9.37e-28 Bipolar disorder and schizophrenia; BRCA trans rs11039798 0.588 rs7108164 chr11:48626363 A/C cg15704280 chr7:45808275 SEPT13 0.52 8.96 0.33 3.48e-18 Axial length; BRCA cis rs7095944 0.644 rs965484 chr10:126453481 T/C cg08799069 chr10:126477246 METTL10 -0.4 -9.49 -0.35 4.41e-20 Asthma; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19346786 chr7:2764209 NA -0.33 -10.4 -0.38 1.69e-23 Height; BRCA cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg10057126 chr4:77819792 ANKRD56 0.67 15.63 0.53 7.02e-47 Emphysema distribution in smoking; BRCA cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg03517284 chr6:25882590 NA 0.38 8.02 0.3 4.93e-15 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs66696214 chr5:93424533 G/A cg25358565 chr5:93447407 FAM172A 1.24 19.5 0.61 8.3e-67 Diabetic retinopathy; BRCA cis rs1707322 1.000 rs12124291 chr1:46432132 G/A cg06784218 chr1:46089804 CCDC17 0.46 10.93 0.4 1.34e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7618915 0.547 rs4130905 chr3:52709831 A/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.29 -0.44 2.59e-31 Bipolar disorder; BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -12.45 -0.44 5.36e-32 Bipolar disorder and schizophrenia; BRCA cis rs514406 0.505 rs856721 chr1:53162156 C/A cg16325326 chr1:53192061 ZYG11B 0.89 24.58 0.7 2.15e-94 Monocyte count; BRCA trans rs75804782 0.641 rs72983834 chr2:239319895 G/A cg01134436 chr17:81009848 B3GNTL1 0.77 9.69 0.36 8.3e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg23711669 chr6:146136114 FBXO30 0.8 19.17 0.6 4.48e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg20818283 chr2:191399100 TMEM194B -0.38 -8.88 -0.33 6.82e-18 Pulse pressure; BRCA cis rs4240897 0.935 rs4846082 chr1:12042443 C/T cg13216073 chr1:12042593 MFN2 0.56 13.86 0.48 2.2e-38 Tuberculosis; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg26119090 chr2:26468346 HADHA;HADHB 1.06 22.11 0.66 6.54e-81 Gut microbiome composition (summer); BRCA cis rs78456975 1.000 rs13414537 chr2:1556330 C/T cg01028140 chr2:1542097 TPO -0.82 -15.46 -0.52 5.06e-46 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs703842 1.000 rs10783848 chr12:58196528 G/A cg00677455 chr12:58241039 CTDSP2 0.63 15.47 0.52 4.28e-46 Multiple sclerosis; BRCA cis rs13191362 0.507 rs2155506 chr6:163035342 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.45 -8.71 -0.33 2.59e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1499972 0.941 rs817506 chr3:117679394 A/G cg07612923 chr3:117604196 NA -0.6 -8.25 -0.31 9.26e-16 Schizophrenia; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg04518342 chr5:131593106 PDLIM4 0.35 8.76 0.33 1.74e-17 Breast cancer; BRCA cis rs10927875 1.000 rs4307563 chr1:16313788 C/T cg21385522 chr1:16154831 NA -0.62 -11.47 -0.41 7.68e-28 Dilated cardiomyopathy; BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg00166722 chr3:10149974 C3orf24 0.58 10.07 0.37 3.22e-22 Alzheimer's disease; BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg13047869 chr3:10149882 C3orf24 0.56 10.4 0.38 1.67e-23 Alzheimer's disease; BRCA cis rs13108904 0.901 rs7668661 chr4:1300172 A/G cg00684032 chr4:1343700 KIAA1530 0.31 8.0 0.3 5.76e-15 Obesity-related traits; BRCA cis rs7408868 1.000 rs10415431 chr19:15277027 G/A cg14696996 chr19:15285081 NOTCH3 1.0 14.59 0.5 7.93e-42 Pulse pressure; BRCA cis rs9814567 1.000 rs11706117 chr3:134212526 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.51 -0.32 1.29e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.4 -0.32 2.91e-16 Alzheimer's disease (late onset); BRCA cis rs9381040 0.655 rs2294696 chr6:41036988 A/G cg04346459 chr6:41068666 NFYA;LOC221442 0.46 10.18 0.37 1.2e-22 Alzheimer's disease (late onset); BRCA cis rs875971 0.862 rs4718319 chr7:65652784 C/A cg11764359 chr7:65958608 NA -0.76 -17.43 -0.57 5.6e-56 Aortic root size; BRCA cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.42 0.47 2.35e-36 Colorectal cancer; BRCA cis rs17270561 0.609 rs6924782 chr6:25735816 C/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs9487051 0.768 rs398944 chr6:109523444 T/G cg01475377 chr6:109611718 NA -0.45 -11.4 -0.41 1.58e-27 Reticulocyte fraction of red cells; BRCA cis rs1003719 0.788 rs2835589 chr21:38463342 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs59698941 0.527 rs11742089 chr5:132178930 G/A cg14825688 chr5:132208181 LEAP2 -0.37 -8.48 -0.32 1.58e-16 Apolipoprotein A-IV levels; BRCA cis rs807669 0.544 rs2040771 chr22:19161935 C/T cg02655711 chr22:19163373 SLC25A1 0.51 11.93 0.43 9.11e-30 Metabolite levels; BRCA cis rs3768617 0.510 rs2296300 chr1:183099701 G/A ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs1577917 1.000 rs6940458 chr6:86644992 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.2 -0.43 6.43e-31 Response to antipsychotic treatment; BRCA cis rs1475911 0.708 rs8129075 chr21:43523430 G/T cg24372256 chr21:43528868 UMODL1;C21orf128 -0.56 -12.89 -0.45 5.94e-34 IgG glycosylation; BRCA cis rs34779708 0.966 rs4934735 chr10:35496730 C/T cg03585969 chr10:35415529 CREM -0.48 -10.08 -0.37 2.81e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6788895 0.661 rs77431731 chr3:150489911 T/G cg09723797 chr3:150481914 SIAH2 0.73 8.94 0.33 4.26e-18 Breast cancer; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg27588902 chr6:42928151 GNMT -0.3 -9.59 -0.35 1.94e-20 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs60871478 1.000 rs4397290 chr7:828493 T/C cg27478167 chr7:817139 HEATR2 0.5 10.32 0.38 3.42e-23 Cerebrospinal P-tau181p levels; BRCA cis rs897984 0.572 rs112906665 chr16:31040139 T/C cg02466173 chr16:30829666 NA -0.42 -9.36 -0.35 1.38e-19 Dementia with Lewy bodies; BRCA trans rs3942852 0.806 rs10734562 chr11:48128189 A/T cg03929089 chr4:120376271 NA 0.44 8.31 0.31 5.9e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs1593 0.532 rs11132388 chr4:187219418 T/C cg14349977 chr4:187219430 NA -0.64 -11.19 -0.4 1.09e-26 Activated partial thromboplastin time; BRCA cis rs12893668 0.572 rs1606 chr14:104161281 G/A cg24130564 chr14:104152367 KLC1 -0.41 -8.74 -0.33 2.04e-17 Reticulocyte count; BRCA cis rs7945705 0.840 rs10840136 chr11:8885024 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -14.07 -0.49 2.41e-39 Hemoglobin concentration; BRCA cis rs7666738 0.830 rs6848404 chr4:98946750 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs919433 0.857 rs36071109 chr2:198183191 C/A cg10820045 chr2:198174542 NA -0.38 -8.0 -0.3 5.73e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9814567 0.806 rs9857242 chr3:134316378 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.54 17.21 0.56 8.29e-55 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs7944735 0.517 rs1827503 chr11:48225115 G/T cg15704280 chr7:45808275 SEPT13 0.55 8.02 0.3 5.04e-15 Intraocular pressure; BRCA cis rs758324 0.947 rs1604080 chr5:131176644 A/G cg06307176 chr5:131281290 NA -0.52 -10.37 -0.38 2.12e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs9443645 0.527 rs1413968 chr6:79791042 A/G cg05283184 chr6:79620031 NA -0.36 -8.42 -0.32 2.41e-16 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg08132940 chr7:1081526 C7orf50 -0.6 -8.74 -0.33 2.03e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9311474 0.652 rs614288 chr3:52220203 T/C cg15698299 chr3:52233019 ALAS1 -0.34 -7.82 -0.3 2.23e-14 Electroencephalogram traits; BRCA cis rs28374715 0.681 rs7165396 chr15:41586947 T/C cg18705301 chr15:41695430 NDUFAF1 -1.03 -23.98 -0.69 4e-91 Ulcerative colitis; BRCA cis rs3733585 0.673 rs4311316 chr4:9955971 A/C cg00071950 chr4:10020882 SLC2A9 0.43 10.27 0.38 5.04e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs72772090 0.908 rs17086588 chr5:96044914 C/T cg17330273 chr5:96107758 CAST;ERAP1 0.45 10.46 0.38 9.28e-24 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg11752832 chr7:134001865 SLC35B4 0.51 12.86 0.45 8.04e-34 Mean platelet volume; BRCA trans rs1973993 0.603 rs1967769 chr1:96993449 C/T cg10631902 chr5:14652156 NA 0.4 10.06 0.37 3.27e-22 Weight; BRCA cis rs651907 0.535 rs12631513 chr3:101517476 A/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.5 0.5 2.04e-41 Colorectal cancer; BRCA cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.47 -0.44 4.14e-32 Developmental language disorder (linguistic errors); BRCA trans rs2204008 0.614 rs4578492 chr12:38036350 T/C cg06521331 chr12:34319734 NA -0.54 -9.69 -0.36 8.55e-21 Bladder cancer; BRCA cis rs7666738 0.830 rs6829567 chr4:99047340 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs7824557 0.751 rs2099456 chr8:11127001 A/C cg06636001 chr8:8085503 FLJ10661 0.52 10.33 0.38 3.09e-23 Retinal vascular caliber; BRCA cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.89 14.34 0.49 1.28e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11690935 0.959 rs35391289 chr2:172634983 A/C cg13550731 chr2:172543902 DYNC1I2 -0.9 -28.25 -0.75 1.46e-114 Schizophrenia; BRCA cis rs2288073 0.965 rs13395596 chr2:24410738 T/C cg26838691 chr2:24397539 C2orf84 -0.48 -8.67 -0.32 3.46e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs35306767 0.953 rs1106064 chr10:957211 G/A cg26597838 chr10:835615 NA 0.87 15.6 0.53 9.49e-47 Eosinophil percentage of granulocytes; BRCA cis rs9381040 0.610 rs2294694 chr6:41046177 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.66 -0.32 3.86e-17 Alzheimer's disease (late onset); BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg24829409 chr8:58192753 C8orf71 -0.47 -8.0 -0.3 6.03e-15 Developmental language disorder (linguistic errors); BRCA cis rs10876993 0.789 rs1689600 chr12:58049645 A/T cg18357645 chr12:58087776 OS9 0.44 12.43 0.44 6.21e-32 Celiac disease or Rheumatoid arthritis; BRCA cis rs9868809 0.505 rs13063223 chr3:48750340 G/A cg01304814 chr3:48885189 PRKAR2A 0.56 7.86 0.3 1.69e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA trans rs11165623 0.564 rs7523597 chr1:97000989 A/G cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.11e-30 Hip circumference;Waist circumference; BRCA cis rs2762353 0.639 rs566530 chr6:25878361 T/C cg12310025 chr6:25882481 NA -0.49 -11.89 -0.43 1.34e-29 Blood metabolite levels; BRCA cis rs7520050 0.966 rs809775 chr1:46538040 A/T cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.41e-19 Red blood cell count;Reticulocyte count; BRCA cis rs3770081 1.000 rs2303340 chr2:86333193 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 -0.62 -8.56 -0.32 8.26e-17 Facial emotion recognition (sad faces); BRCA trans rs1814175 0.519 rs10839291 chr11:49514321 G/A cg03929089 chr4:120376271 NA 0.64 12.64 0.45 7.27e-33 Height; BRCA cis rs1788820 0.917 rs1788762 chr18:21132571 G/C cg14672496 chr18:21087552 C18orf8 0.34 8.29 0.31 6.45e-16 Body mass index; BRCA cis rs72781680 0.821 rs72796369 chr2:24162663 G/T cg08917208 chr2:24149416 ATAD2B 0.64 10.71 0.39 9.64e-25 Lymphocyte counts; BRCA cis rs12701220 0.857 rs1057558 chr7:1062366 A/G cg26769984 chr7:1090371 C7orf50 0.52 9.69 0.36 8.13e-21 Bronchopulmonary dysplasia; BRCA cis rs4900538 0.963 rs1190553 chr14:102915331 G/T cg18135206 chr14:102964638 TECPR2 -1.04 -28.84 -0.75 8.88e-118 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7267979 0.789 rs9927 chr20:25277244 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.32 0.31 5.51e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10465746 0.967 rs7531537 chr1:84414924 C/T cg10977910 chr1:84465055 TTLL7 0.49 9.89 0.36 1.45e-21 Obesity-related traits; BRCA cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg06640241 chr16:89574553 SPG7 0.56 12.66 0.45 6.3e-33 Multiple myeloma (IgH translocation); BRCA cis rs9381040 0.610 rs4140580 chr6:41041742 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA cis rs7927771 0.524 rs10742814 chr11:47554337 G/A cg20307385 chr11:47447363 PSMC3 0.45 10.18 0.37 1.14e-22 Subjective well-being; BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg13047869 chr3:10149882 C3orf24 0.53 10.03 0.37 4.34e-22 Alzheimer's disease; BRCA trans rs9858542 0.953 rs9824092 chr3:49674147 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.42 -10.24 -0.38 7.06e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs483180 0.512 rs677277 chr1:120202298 C/T cg19096424 chr1:120255104 PHGDH -0.39 -8.73 -0.33 2.13e-17 Macular telangiectasia type 2; BRCA cis rs66887589 0.748 rs28439855 chr4:120262256 G/A cg09307838 chr4:120376055 NA 0.44 9.54 0.35 2.91e-20 Diastolic blood pressure; BRCA cis rs4820539 0.966 rs2157709 chr22:23457420 T/C cg14186256 chr22:23484241 RTDR1 0.75 22.88 0.67 4.12e-85 Bone mineral density; BRCA cis rs12365397 0.552 rs7122200 chr11:43163328 C/G cg03447554 chr11:43094025 NA 0.44 8.19 0.31 1.38e-15 Migraine; BRCA cis rs6546550 0.901 rs6546559 chr2:70145833 G/A cg02498382 chr2:70120550 SNRNP27 -0.52 -11.33 -0.41 3.09e-27 Prevalent atrial fibrillation; BRCA cis rs17095355 1.000 rs11194926 chr10:111700922 A/G cg00817464 chr10:111662876 XPNPEP1 0.4 10.01 0.37 5.13e-22 Biliary atresia; BRCA cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg13319975 chr6:146136371 FBXO30 0.42 9.78 0.36 3.73e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg25036284 chr2:26402008 FAM59B -0.63 -10.54 -0.38 4.75e-24 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs61306359 chr8:58134646 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.895 rs2965182 chr19:19548246 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 7.98 0.3 6.61e-15 Tonsillectomy; BRCA trans rs7615952 0.641 rs66520539 chr3:125780374 G/A cg07211511 chr3:129823064 LOC729375 -0.63 -11.04 -0.4 4.71e-26 Blood pressure (smoking interaction); BRCA cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg03354898 chr7:1950403 MAD1L1 0.38 8.51 0.32 1.25e-16 Bipolar disorder and schizophrenia; BRCA cis rs6064559 0.545 rs1062600 chr20:56137798 G/A cg16101800 chr20:56136569 PCK1 -0.45 -11.56 -0.42 3.23e-28 Hemoglobin concentration; BRCA cis rs7918232 0.800 rs7907981 chr10:27444329 T/C cg14240646 chr10:27532245 ACBD5 -0.67 -12.04 -0.43 3.01e-30 Breast cancer; BRCA cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.62 14.11 0.49 1.56e-39 Colorectal cancer; BRCA cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06544989 chr22:39130855 UNC84B 0.36 8.59 0.32 6.75e-17 Menopause (age at onset); BRCA cis rs6138458 0.585 rs1007881 chr20:25014385 A/G cg26195577 chr20:24973756 C20orf3 0.6 14.62 0.5 5.67e-42 Blood protein levels; BRCA cis rs2304069 0.550 rs216144 chr5:149445480 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.56 10.88 0.4 2.01e-25 HIV-1 control; BRCA cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg26597838 chr10:835615 NA 0.92 14.69 0.5 2.79e-42 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs9884501 chr4:98893721 A/C cg05340658 chr4:99064831 C4orf37 0.61 14.79 0.5 8.91e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6433857 0.657 rs2368178 chr2:181501938 T/C cg23363182 chr2:181467187 NA -0.45 -9.73 -0.36 5.81e-21 Body mass index; BRCA cis rs2842992 0.872 rs9456440 chr6:160074463 G/T cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.04 0.4 4.47e-26 Age-related macular degeneration (geographic atrophy); BRCA trans rs9858542 0.953 rs9853683 chr3:49512588 A/G cg21659725 chr3:3221576 CRBN -0.47 -9.99 -0.37 6.33e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs586533 0.881 rs636893 chr11:99504897 G/C cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7474896 0.559 rs1212108 chr10:38094322 A/C cg25427524 chr10:38739819 LOC399744 -0.53 -9.06 -0.34 1.63e-18 Obesity (extreme); BRCA cis rs7903847 0.642 rs10882915 chr10:99142184 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs936229 0.668 rs67411922 chr15:75187612 A/G cg14664628 chr15:75095509 CSK -0.74 -18.05 -0.58 3.45e-59 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg18230493 chr5:56204884 C5orf35 0.61 13.0 0.46 1.88e-34 Initial pursuit acceleration; BRCA cis rs7246657 0.943 rs28402338 chr19:37833923 G/A cg18154014 chr19:37997991 ZNF793 0.61 11.38 0.41 1.85e-27 Coronary artery calcification; BRCA cis rs72772090 0.522 rs17477045 chr5:95987984 A/C cg17330273 chr5:96107758 CAST;ERAP1 0.52 8.1 0.31 2.82e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6964587 1.000 rs2097739 chr7:91711466 C/T cg17063962 chr7:91808500 NA 0.53 12.45 0.44 5.15e-32 Breast cancer; BRCA cis rs2153535 0.580 rs1335643 chr6:8488021 T/G cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.25e-18 Motion sickness; BRCA cis rs9399135 0.967 rs12526055 chr6:135325918 C/T cg24558204 chr6:135376177 HBS1L 0.44 11.94 0.43 8.18e-30 Red blood cell count; BRCA cis rs6570726 0.935 rs419854 chr6:145844085 A/C cg23711669 chr6:146136114 FBXO30 0.64 14.97 0.51 1.25e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs2836974 0.831 rs6517521 chr21:40551588 A/G cg17971929 chr21:40555470 PSMG1 0.77 18.33 0.59 1.3e-60 Cognitive function; BRCA cis rs798554 0.704 rs798531 chr7:2770067 G/C cg13628971 chr7:2884303 GNA12 0.39 8.5 0.32 1.31e-16 Height; BRCA cis rs6570726 0.935 rs372378 chr6:145816227 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.05 0.51 4.81e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs854765 0.520 rs9899355 chr17:17898243 C/T cg04398451 chr17:18023971 MYO15A -0.69 -14.86 -0.51 4e-43 Total body bone mineral density; BRCA cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg08885076 chr2:99613938 TSGA10 -0.54 -12.41 -0.44 7.59e-32 Chronic sinus infection; BRCA cis rs758324 0.947 rs6596040 chr5:131198777 C/T cg06307176 chr5:131281290 NA 0.53 10.32 0.38 3.51e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1865760 0.566 rs9366634 chr6:26072396 C/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.63 0.42 1.67e-28 Height; BRCA cis rs2304069 0.913 rs7734382 chr5:149383241 A/T cg12661370 chr5:149340060 SLC26A2 0.51 8.05 0.3 4.18e-15 HIV-1 control; BRCA trans rs9858542 0.953 rs9858280 chr3:49597737 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.55 -0.35 2.68e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4595586 0.545 rs1562728 chr12:39405740 C/T cg26384229 chr12:38710491 ALG10B 0.43 9.61 0.36 1.69e-20 Morning vs. evening chronotype; BRCA cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg05552183 chr6:42928497 GNMT 0.82 20.58 0.63 1.37e-72 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7412746 0.658 rs11581757 chr1:150892244 A/G cg15448220 chr1:150897856 SETDB1 0.36 7.95 0.3 8.34e-15 Melanoma; BRCA cis rs2742234 0.541 rs11528481 chr10:43737767 C/A cg15436174 chr10:43711423 RASGEF1A 0.49 9.7 0.36 7.4e-21 Hirschsprung disease; BRCA cis rs68170813 0.522 rs12535814 chr7:107038432 A/T cg02696742 chr7:106810147 HBP1 -0.48 -8.27 -0.31 8.02e-16 Coronary artery disease; BRCA cis rs6714710 0.557 rs17490429 chr2:98449024 G/A cg26665480 chr2:98280029 ACTR1B 0.6 13.82 0.48 3.49e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7089973 0.604 rs7923693 chr10:116619566 A/G cg23260525 chr10:116636907 FAM160B1 0.3 7.93 0.3 1e-14 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs4713118 0.527 rs9461433 chr6:28095172 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.02 -0.3 5.22e-15 Parkinson's disease; BRCA cis rs13118159 0.505 rs1250128 chr4:1257311 T/C cg02475777 chr4:1388615 CRIPAK -0.67 -12.51 -0.44 2.8099999999999997e-32 Longevity; BRCA cis rs7552404 0.731 rs1493367 chr1:76344011 C/A cg22875332 chr1:76189707 ACADM -0.54 -10.17 -0.37 1.26e-22 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs7647973 0.710 rs7629322 chr3:49621994 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.45 -8.91 -0.33 5.2e-18 Menarche (age at onset); BRCA cis rs7903847 0.642 rs12359257 chr10:99136359 A/T cg08345082 chr10:99160200 RRP12 -0.3 -8.29 -0.31 6.72e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs3806843 0.676 rs2569159 chr5:140030710 C/T cg21161173 chr5:140098174 VTRNA1-2 0.31 7.84 0.3 1.94e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs858239 0.899 rs5850 chr7:23314547 C/T cg23682824 chr7:23144976 KLHL7 0.34 8.6 0.32 6.12e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs10851411 0.697 rs17709867 chr15:42800767 C/T cg21293051 chr15:42870591 STARD9 0.57 9.02 0.34 2.13e-18 Glucose homeostasis traits; BRCA trans rs6089829 0.962 rs6062778 chr20:61663959 A/G cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs10193935 0.901 rs9309082 chr2:42581412 A/G cg27598129 chr2:42591480 NA -0.87 -14.28 -0.49 2.3e-40 Colonoscopy-negative controls vs population controls; BRCA cis rs7766436 0.961 rs6900627 chr6:22570245 G/A cg13666174 chr6:22585274 NA -0.4 -9.14 -0.34 8.22e-19 Coronary artery disease; BRCA cis rs7091068 0.522 rs10882322 chr10:95483273 C/G cg20715218 chr10:95462985 C10orf4 0.48 9.13 0.34 8.67e-19 Urinary tract infection frequency; BRCA cis rs2806561 0.734 rs7548692 chr1:23354877 T/A cg19743168 chr1:23544995 NA 0.36 8.39 0.31 3.21e-16 Height; BRCA cis rs365132 1.000 rs353467 chr5:176445698 T/C cg16309518 chr5:176445507 NA -0.52 -13.24 -0.46 1.51e-35 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2243480 1.000 rs6460261 chr7:65215580 T/C cg18252515 chr7:66147081 NA 0.91 13.02 0.46 1.61e-34 Diabetic kidney disease; BRCA cis rs651907 0.514 rs12636046 chr3:101434448 T/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.43 -0.32 2.35e-16 Colorectal cancer; BRCA cis rs1707322 1.000 rs6695421 chr1:46380207 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.76 0.39 6.02e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs561341 0.769 rs559228 chr17:30294527 T/C cg23018236 chr17:30244563 NA -0.61 -10.02 -0.37 4.87e-22 Hip circumference adjusted for BMI; BRCA cis rs9517313 0.551 rs2274051 chr13:99091634 A/G cg20487152 chr13:99095054 FARP1 0.4 10.31 0.38 3.65e-23 Neuroticism; BRCA cis rs9325144 0.560 rs6582561 chr12:38666821 G/A cg13010199 chr12:38710504 ALG10B -0.38 -8.7 -0.33 2.89e-17 Morning vs. evening chronotype; BRCA cis rs2559856 1.000 rs2559855 chr12:102090080 A/G cg12924262 chr12:102091054 CHPT1 -0.38 -8.74 -0.33 2.05e-17 Blood protein levels; BRCA cis rs6582630 0.537 rs6582500 chr12:38534206 G/A cg26384229 chr12:38710491 ALG10B 0.78 18.13 0.58 1.41e-59 Drug-induced liver injury (flucloxacillin); BRCA trans rs61931739 0.517 rs12816252 chr12:34067693 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.12 0.49 1.32e-39 Morning vs. evening chronotype; BRCA cis rs1580019 0.922 rs59938271 chr7:32484844 T/C cg06627557 chr7:32535165 LSM5;AVL9 0.89 19.5 0.61 8.03e-67 Cognitive ability; BRCA cis rs13392177 0.684 rs6720449 chr2:219080978 G/A cg00012203 chr2:219082015 ARPC2 -0.51 -10.39 -0.38 1.88e-23 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs6879260 0.963 rs1035412 chr5:179729328 C/T cg23221052 chr5:179740743 GFPT2 -0.67 -14.04 -0.49 3.33e-39 Height; BRCA cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg24642439 chr20:33292090 TP53INP2 0.68 14.02 0.49 3.95e-39 Coronary artery disease; BRCA cis rs67311347 1.000 rs1454497 chr3:40496326 C/T cg01475735 chr3:40494733 NA 0.48 10.01 0.37 5.26e-22 Renal cell carcinoma; BRCA cis rs2404602 0.716 rs8025134 chr15:76781729 C/T cg23625390 chr15:77176239 SCAPER 0.4 9.36 0.35 1.34e-19 Blood metabolite levels; BRCA cis rs7666738 0.546 rs34621463 chr4:98793357 G/C cg05340658 chr4:99064831 C4orf37 0.55 10.76 0.39 6.32e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.882 rs2030564 chr3:10039044 A/G cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs4595586 0.545 rs6580893 chr12:39371885 G/T cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.62e-19 Morning vs. evening chronotype; BRCA cis rs7044106 0.791 rs4836830 chr9:123483668 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.73 16.43 0.54 7.78e-51 Hip circumference adjusted for BMI; BRCA cis rs769267 0.931 rs2965193 chr19:19454828 G/A cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.44 -0.35 6.83e-20 Tonsillectomy; BRCA cis rs72781680 0.821 rs116583405 chr2:24208221 T/C cg08917208 chr2:24149416 ATAD2B 0.62 10.47 0.38 8.48e-24 Lymphocyte counts; BRCA trans rs4718428 0.662 rs34577323 chr7:66310041 G/C cg18876405 chr7:65276391 NA 0.43 8.47 0.32 1.63e-16 Corneal structure; BRCA cis rs9443645 0.836 rs9352676 chr6:79629999 A/G cg11833968 chr6:79620685 NA -0.43 -9.58 -0.35 2.12e-20 Intelligence (multi-trait analysis); BRCA cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg03709012 chr19:19516395 GATAD2A -0.75 -17.01 -0.56 8.07e-54 Tonsillectomy; BRCA cis rs1862618 0.754 rs252899 chr5:56188569 G/C cg18230493 chr5:56204884 C5orf35 -0.74 -14.69 -0.5 2.79e-42 Initial pursuit acceleration; BRCA cis rs870825 0.616 rs6419939 chr4:185642869 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg01579765 chr21:45077557 HSF2BP -0.4 -10.74 -0.39 7.47e-25 Mean corpuscular volume; BRCA cis rs1710278 0.967 rs1017723 chr10:127746825 A/G cg22975853 chr10:127789788 ADAM12 -0.33 -8.61 -0.32 5.49e-17 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs9359856 0.564 rs72917989 chr6:90470385 A/T cg13799429 chr6:90582589 CASP8AP2 -0.7 -8.55 -0.32 8.85e-17 Bipolar disorder; BRCA cis rs2599510 0.755 rs67257914 chr2:32804018 G/A cg02381751 chr2:32503542 YIPF4 0.43 8.32 0.31 5.44e-16 Interleukin-18 levels; BRCA cis rs10504229 0.639 rs66667899 chr8:58117065 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs7660520 0.524 rs6839881 chr4:183729137 A/T cg04181038 chr4:183730758 NA 0.53 10.1 0.37 2.28e-22 Pediatric autoimmune diseases; BRCA cis rs853679 0.517 rs9468298 chr6:28122345 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs10838687 0.736 rs4647741 chr11:47254010 T/C cg25783544 chr11:47291846 MADD 0.42 7.84 0.3 1.83e-14 Proinsulin levels; BRCA cis rs6893300 0.542 rs3797774 chr5:179193970 C/T cg14593053 chr5:179126677 CANX 0.48 12.99 0.46 2.04e-34 Resting heart rate; BRCA cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg26597838 chr10:835615 NA 0.91 16.26 0.54 5.33e-50 Eosinophil percentage of granulocytes; BRCA cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.75 12.15 0.43 1.1e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1865760 0.892 rs2328903 chr6:25935765 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.83 0.36 2.59e-21 Height; BRCA cis rs7246657 0.722 rs2927739 chr19:38149330 C/A cg23950597 chr19:37808831 NA 0.52 8.86 0.33 8.12e-18 Coronary artery calcification; BRCA cis rs1448094 0.717 rs7305873 chr12:86290831 G/C cg19622623 chr12:86230825 RASSF9 -0.28 -8.09 -0.3 3.04e-15 Major depressive disorder; BRCA trans rs1994135 0.617 rs12821909 chr12:33723466 T/C cg13010199 chr12:38710504 ALG10B 0.42 7.92 0.3 1.05e-14 Resting heart rate; BRCA cis rs9486719 0.947 rs12208556 chr6:96903486 C/T cg06623918 chr6:96969491 KIAA0776 -0.73 -14.13 -0.49 1.22e-39 Migraine;Coronary artery disease; BRCA cis rs11945232 1.000 rs10027786 chr4:88347512 A/G cg23841344 chr4:88312519 HSD17B11 -0.47 -9.5 -0.35 4.02e-20 Intelligence (multi-trait analysis); BRCA cis rs9473147 0.543 rs9473119 chr6:47450618 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.56 0.35 2.48e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs514406 0.679 rs960570 chr1:53237763 A/G cg27535305 chr1:53392650 SCP2 0.49 11.33 0.41 3.02e-27 Monocyte count; BRCA cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg10169327 chr19:45448959 APOC2 0.31 7.81 0.3 2.28e-14 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6964587 1.000 rs6974607 chr7:91750116 G/A cg22117172 chr7:91764530 CYP51A1 0.23 7.84 0.3 1.9e-14 Breast cancer; BRCA trans rs61931739 0.534 rs7965503 chr12:34199349 A/G cg13010199 chr12:38710504 ALG10B 0.49 9.53 0.35 3.12e-20 Morning vs. evening chronotype; BRCA cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg24110177 chr3:50126178 RBM5 -0.36 -9.67 -0.36 9.88e-21 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.563 rs6517522 chr21:40553845 T/C cg11890956 chr21:40555474 PSMG1 0.78 19.15 0.6 6.19e-65 Cognitive function; BRCA cis rs9790314 0.967 rs336586 chr3:161081347 G/A cg03342759 chr3:160939853 NMD3 -0.63 -13.43 -0.47 2.1e-36 Morning vs. evening chronotype; BRCA cis rs13191362 0.507 rs2023015 chr6:163060528 A/T cg06582575 chr6:163149167 PACRG;PARK2 -0.47 -9.07 -0.34 1.4e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.791 rs28579101 chr4:98843203 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.22 0.37 8.39e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.699 rs4276278 chr4:9948870 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.59 -0.39 2.86e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg08754478 chr10:133766260 PPP2R2D -0.69 -14.15 -0.49 9.24e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg11764359 chr7:65958608 NA 0.65 11.66 0.42 1.27e-28 Aortic root size; BRCA cis rs7264396 0.836 rs961020 chr20:34182069 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.52 -10.43 -0.38 1.24e-23 Total cholesterol levels; BRCA cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg22535103 chr8:58192502 C8orf71 -0.46 -9.2 -0.34 4.87e-19 Developmental language disorder (linguistic errors); BRCA cis rs1707322 0.721 rs11211178 chr1:46227566 G/T cg03146154 chr1:46216737 IPP 0.54 12.11 0.43 1.49e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs701145 0.938 rs1515653 chr3:154076654 A/G cg17054900 chr3:154042577 DHX36 0.67 11.54 0.42 4e-28 Coronary artery disease; BRCA cis rs10751667 0.666 rs10902235 chr11:938892 T/C cg10932868 chr11:921992 NA 0.49 12.59 0.45 1.21e-32 Alzheimer's disease (late onset); BRCA cis rs7809950 1.000 rs17154104 chr7:107090698 C/T cg23024343 chr7:107201750 COG5 -0.43 -9.93 -0.37 1.09e-21 Coronary artery disease; BRCA trans rs61931739 0.517 rs34760282 chr12:34153711 G/T cg26384229 chr12:38710491 ALG10B 0.69 14.64 0.5 4.48e-42 Morning vs. evening chronotype; BRCA cis rs9486719 0.901 rs13206547 chr6:97006942 T/C cg06623918 chr6:96969491 KIAA0776 -0.77 -13.98 -0.48 6.03e-39 Migraine;Coronary artery disease; BRCA cis rs6088813 1.000 rs6087704 chr20:34001058 C/T cg14752227 chr20:34000481 UQCC -0.43 -9.08 -0.34 1.39e-18 Height; BRCA trans rs12517041 1.000 rs6868335 chr5:23316641 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.09 -0.3 2.99e-15 Calcium levels; BRCA trans rs7200543 0.883 rs4985148 chr16:15147788 A/C cg24683922 chr1:11983373 KIAA2013 -0.37 -8.6 -0.32 6.24e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg11279151 chr3:101281821 RG9MTD1 -0.48 -10.3 -0.38 3.88e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9733 0.715 rs7534124 chr1:150739073 C/T cg18016565 chr1:150552671 MCL1 -0.37 -8.66 -0.32 3.79e-17 Tonsillectomy; BRCA cis rs778371 0.723 rs6704763 chr2:233592487 C/T cg08000102 chr2:233561755 GIGYF2 0.85 20.94 0.64 1.52e-74 Schizophrenia; BRCA cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.82e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs11690935 0.918 rs11757 chr2:172641045 C/G cg13550731 chr2:172543902 DYNC1I2 -0.93 -30.68 -0.77 9.06e-128 Schizophrenia; BRCA cis rs2276314 0.793 rs77590522 chr18:33629410 C/G cg05985134 chr18:33552581 C18orf21 0.62 10.75 0.39 6.85e-25 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9443645 0.527 rs1415859 chr6:79794858 A/G cg05283184 chr6:79620031 NA -0.36 -8.12 -0.31 2.46e-15 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs3907020 chr4:99038583 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.62 0.55 8.5e-52 Colonoscopy-negative controls vs population controls; BRCA trans rs7395662 0.591 rs11039858 chr11:48611651 C/T cg00717180 chr2:96193071 NA -0.38 -10.24 -0.38 6.67e-23 HDL cholesterol; BRCA cis rs4563143 0.663 rs5025682 chr19:29238670 A/C cg12667521 chr19:29218732 NA 0.47 8.92 0.33 4.75e-18 Methadone dose in opioid dependence; BRCA trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs6815814 0.847 rs11725309 chr4:38783848 T/C cg02016764 chr4:38805732 TLR1 -0.61 -9.54 -0.35 3.01e-20 Breast cancer; BRCA cis rs6860806 0.507 rs272883 chr5:131668698 A/G cg12564285 chr5:131593104 PDLIM4 0.35 7.98 0.3 6.85e-15 Breast cancer; BRCA cis rs634534 0.622 rs531612 chr11:65705432 C/T cg26695010 chr11:65641043 EFEMP2 0.39 9.13 0.34 8.65e-19 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs1065852 0.526 rs1062753 chr22:42392811 G/A cg22189786 chr22:42395067 WBP2NL 0.43 8.65 0.32 4.27e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs10464366 0.746 rs6945402 chr7:39145385 A/T cg20302533 chr7:39170763 POU6F2 0.38 7.97 0.3 7.41e-15 IgG glycosylation; BRCA cis rs478304 0.651 rs4930312 chr11:65499719 G/A cg10518572 chr11:65560635 OVOL1 -0.28 -8.13 -0.31 2.19e-15 Acne (severe); BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.78 0.42 4.11e-29 Tonsillectomy; BRCA cis rs10479542 0.642 rs6879665 chr5:178974581 T/A cg26516362 chr5:178986906 RUFY1 0.33 7.92 0.3 1.05e-14 Lung cancer; BRCA cis rs6450176 0.909 rs2448 chr5:53302354 T/C ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.52 -0.5 1.65e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs490234 0.783 rs2416967 chr9:128440014 T/C cg14078157 chr9:128172775 NA -0.42 -9.48 -0.35 4.83e-20 Mean arterial pressure; BRCA cis rs765787 0.530 rs4775844 chr15:45542048 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.08 0.3 3.2e-15 Uric acid levels; BRCA cis rs7666738 0.925 rs34423396 chr4:99049031 T/A cg05340658 chr4:99064831 C4orf37 0.6 12.88 0.45 6.34e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.42 0.32 2.39e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs922692 0.715 rs11072803 chr15:79077878 G/A cg04896959 chr15:78267971 NA 0.37 8.62 0.32 5.15e-17 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs514406 0.565 rs897732 chr1:53382816 A/C cg25767906 chr1:53392781 SCP2 -0.48 -10.67 -0.39 1.49e-24 Monocyte count; BRCA cis rs875971 0.898 rs6977501 chr7:65693342 T/C cg11764359 chr7:65958608 NA -0.79 -18.63 -0.59 3.45e-62 Aortic root size; BRCA cis rs2836974 1.000 rs12710454 chr21:40656919 A/G cg11644478 chr21:40555479 PSMG1 0.74 14.89 0.51 2.74e-43 Cognitive function; BRCA cis rs12760731 0.565 rs12047117 chr1:178132608 G/A cg00404053 chr1:178313656 RASAL2 0.64 7.96 0.3 7.93e-15 Obesity-related traits; BRCA cis rs2841277 0.708 rs9671643 chr14:105408030 A/G cg14403583 chr14:105418241 AHNAK2 -0.38 -8.91 -0.33 5.48e-18 Rheumatoid arthritis; BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.08 0.3 3.33e-15 Platelet count; BRCA cis rs72781680 1.000 rs12616985 chr2:24165511 A/C cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs7772486 0.790 rs2250387 chr6:146205233 C/T cg13319975 chr6:146136371 FBXO30 -0.41 -9.43 -0.35 7.32e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs9818758 0.607 rs66991555 chr3:49228643 A/G cg00383909 chr3:49044727 WDR6 0.72 12.36 0.44 1.31e-31 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs11098499 0.865 rs28753180 chr4:120405367 A/T cg09307838 chr4:120376055 NA 0.72 15.28 0.52 3.69e-45 Corneal astigmatism; BRCA cis rs2463822 1.000 rs7481995 chr11:62129312 G/C cg06239285 chr11:62104954 ASRGL1 0.69 11.52 0.41 4.72e-28 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg00339695 chr16:24857497 SLC5A11 -0.43 -8.04 -0.3 4.52e-15 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs6840258 1.000 rs56201818 chr4:87952633 T/C cg08197287 chr4:87952173 AFF1 -0.43 -8.58 -0.32 7.08e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs10089 0.552 rs58595196 chr5:127558338 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.49 9.56 0.35 2.52e-20 Ileal carcinoids; BRCA cis rs10493773 0.928 rs12751296 chr1:86176968 G/A cg17807903 chr1:86174739 ZNHIT6 -0.45 -9.31 -0.35 2.1e-19 Urate levels in overweight individuals; BRCA cis rs7618915 0.501 rs2109634 chr3:52752075 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.22e-26 Bipolar disorder; BRCA cis rs17095355 1.000 rs12571674 chr10:111717608 C/T cg00817464 chr10:111662876 XPNPEP1 0.42 9.3 0.35 2.25e-19 Biliary atresia; BRCA cis rs801193 1.000 rs10234018 chr7:66146284 A/T cg18876405 chr7:65276391 NA -0.59 -14.15 -0.49 1e-39 Aortic root size; BRCA cis rs7618915 0.501 rs1866268 chr3:52719398 C/A cg11041457 chr3:52719354 GNL3;PBRM1 0.38 12.97 0.46 2.51e-34 Bipolar disorder; BRCA cis rs1322639 0.618 rs9505942 chr6:169591793 T/C cg03254818 chr6:169586852 NA 0.46 7.87 0.3 1.49e-14 Pulse pressure; BRCA cis rs2762353 0.538 rs35670731 chr6:25728235 C/T cg03517284 chr6:25882590 NA 0.7 15.88 0.53 4.03e-48 Blood metabolite levels; BRCA cis rs12142240 0.698 rs6703374 chr1:46862332 C/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs17092148 1.000 rs6060040 chr20:33359054 G/C cg16810054 chr20:33298113 TP53INP2 -0.5 -11.34 -0.41 2.82e-27 Neuroticism; BRCA cis rs67311347 1.000 rs4973993 chr3:40452960 T/C cg01475735 chr3:40494733 NA -0.43 -7.91 -0.3 1.13e-14 Renal cell carcinoma; BRCA cis rs4280164 0.945 rs11158635 chr14:24776769 G/T cg16194253 chr14:24768981 DHRS1;C14orf21 -0.46 -7.91 -0.3 1.15e-14 Parent of origin effect on language impairment (paternal); BRCA cis rs6912958 1.000 rs2223880 chr6:88167897 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.5 -10.4 -0.38 1.68e-23 Monocyte percentage of white cells; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg13047869 chr3:10149882 C3orf24 0.57 10.42 0.38 1.43e-23 Alzheimer's disease; BRCA cis rs17228212 1.000 rs731874 chr15:67446831 C/T cg26876701 chr15:67458665 SMAD3 -0.44 -8.48 -0.32 1.57e-16 Coronary heart disease; BRCA cis rs13382862 0.862 rs340595 chr2:20889714 A/G cg10553204 chr2:20871195 GDF7 -0.29 -7.84 -0.3 1.9e-14 Abdominal aortic aneurysm; BRCA cis rs1008375 0.966 rs3775923 chr4:17585625 T/C cg04450456 chr4:17643702 FAM184B 0.38 10.52 0.38 5.64e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs6833312 chr4:98951356 A/T cg05340658 chr4:99064831 C4orf37 0.67 16.82 0.55 8.18e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -8.46 -0.32 1.88e-16 Electroencephalogram traits; BRCA cis rs1635 0.655 rs73742536 chr6:28303243 G/A cg15743358 chr6:28303923 ZNF323 -0.75 -8.56 -0.32 8.52e-17 Schizophrenia; BRCA cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.72e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs953387 1.000 rs6715785 chr2:136910273 C/T cg05194412 chr2:137003533 NA -0.38 -8.83 -0.33 1.04e-17 Arthritis (juvenile idiopathic); BRCA cis rs6938 0.596 rs11072511 chr15:75159433 A/G cg14664628 chr15:75095509 CSK -0.5 -11.68 -0.42 1.09e-28 Breast cancer; BRCA cis rs4566357 0.576 rs10187255 chr2:227913442 T/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.08 -0.3 3.32e-15 Coronary artery disease; BRCA cis rs4845875 0.530 rs4846048 chr1:11846252 A/G cg06193043 chr1:11908199 NPPA -0.34 -7.84 -0.3 1.85e-14 Midregional pro atrial natriuretic peptide levels; BRCA cis rs416603 0.967 rs11640138 chr16:11362729 A/G cg00044050 chr16:11439710 C16orf75 0.42 9.6 0.36 1.72e-20 Type 1 diabetes; BRCA cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg11644478 chr21:40555479 PSMG1 0.71 13.93 0.48 9.98e-39 Cognitive function; BRCA cis rs208346 0.612 rs208356 chr7:2775825 A/T cg18446336 chr7:2847575 GNA12 0.43 9.78 0.36 3.92e-21 Loneliness (linear analysis); BRCA cis rs9467773 0.620 rs2101581 chr6:26622769 G/T cg11502198 chr6:26597334 ABT1 0.56 11.95 0.43 7.89e-30 Intelligence (multi-trait analysis); BRCA cis rs9457247 0.508 rs6902119 chr6:167505791 T/C cg07741184 chr6:167504864 NA 0.32 9.87 0.36 1.78e-21 Crohn's disease; BRCA trans rs61931739 1.000 rs11502817 chr12:34010676 T/C cg26384229 chr12:38710491 ALG10B -0.41 -9.3 -0.35 2.27e-19 Morning vs. evening chronotype; BRCA cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg08048268 chr3:133502702 NA -0.34 -8.37 -0.31 3.61e-16 Iron status biomarkers; BRCA cis rs6815814 0.851 rs4274855 chr4:38777471 C/T cg06935464 chr4:38784597 TLR10 0.47 7.86 0.3 1.63e-14 Breast cancer; BRCA cis rs11098499 1.000 rs6849889 chr4:120186348 A/C cg09307838 chr4:120376055 NA 0.62 12.32 0.44 1.86e-31 Corneal astigmatism; BRCA cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg02659138 chr7:134003124 SLC35B4 0.33 10.16 0.37 1.43e-22 Mean platelet volume; BRCA cis rs7618915 0.547 rs13065019 chr3:52685244 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.0 0.4 6.59e-26 Bipolar disorder; BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg04518342 chr5:131593106 PDLIM4 0.38 8.89 0.33 6.44e-18 Acylcarnitine levels; BRCA trans rs9944715 0.954 rs6507691 chr18:43808648 T/C cg01718231 chr17:29326311 RNF135 -0.45 -8.53 -0.32 1.09e-16 Red cell distribution width;Mean corpuscular volume; BRCA cis rs9463078 0.764 rs6458415 chr6:44881592 G/C cg25276700 chr6:44698697 NA -0.35 -8.09 -0.3 2.91e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2742234 0.541 rs1059484 chr10:43679800 T/G cg15436174 chr10:43711423 RASGEF1A -0.54 -10.87 -0.4 2.25e-25 Hirschsprung disease; BRCA cis rs2153535 0.580 rs7763190 chr6:8484197 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.93e-24 Motion sickness; BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg00166722 chr3:10149974 C3orf24 0.64 11.21 0.41 9.37e-27 Alzheimer's disease; BRCA cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg06238570 chr21:40685208 BRWD1 -0.41 -8.34 -0.31 4.42e-16 Cognitive function; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg08888203 chr3:10149979 C3orf24 0.61 13.03 0.46 1.34e-34 Alzheimer's disease; BRCA cis rs12142240 0.731 rs12385693 chr1:46818921 A/C cg10495392 chr1:46806563 NSUN4 0.43 7.84 0.3 1.96e-14 Menopause (age at onset); BRCA cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg23422044 chr7:1970798 MAD1L1 -0.71 -12.87 -0.45 7.28e-34 Bipolar disorder; BRCA cis rs832540 0.656 rs832573 chr5:56159578 T/C cg12311346 chr5:56204834 C5orf35 -0.44 -9.06 -0.34 1.59e-18 Coronary artery disease; BRCA cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg07148914 chr20:33460835 GGT7 0.38 8.58 0.32 7.05e-17 Height; BRCA cis rs2415984 0.600 rs61993295 chr14:46932614 T/C cg14871534 chr14:47121158 RPL10L -0.37 -8.76 -0.33 1.68e-17 Number of children ever born; BRCA cis rs701145 0.585 rs1632688 chr3:153874139 C/A cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs7903847 0.642 rs6584127 chr10:99142948 A/C cg20016023 chr10:99160130 RRP12 -0.27 -8.76 -0.33 1.71e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2204008 0.837 rs11514225 chr12:38076270 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.12 0.37 1.91e-22 Bladder cancer; BRCA cis rs12477438 0.765 rs7340412 chr2:99661148 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs270601 0.770 rs61352298 chr5:131600589 G/C cg22638593 chr5:131593259 PDLIM4 0.32 7.86 0.3 1.7e-14 Acylcarnitine levels; BRCA trans rs1005277 0.505 rs200931 chr10:38128434 A/C cg17830980 chr10:43048298 ZNF37B -0.41 -9.54 -0.35 2.86e-20 Extrinsic epigenetic age acceleration; BRCA cis rs6570726 0.935 rs447247 chr6:145812678 G/T cg23711669 chr6:146136114 FBXO30 0.64 15.03 0.51 5.92e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs13064411 0.660 rs3829889 chr3:113015464 G/A cg18753928 chr3:113234510 CCDC52 -0.43 -8.11 -0.31 2.64e-15 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -8.23 -0.31 1.07e-15 Total body bone mineral density; BRCA cis rs2070488 1.000 rs2276540 chr3:38512507 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.51 0.63 3.08e-72 Electrocardiographic conduction measures; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg21226059 chr5:178986404 RUFY1 0.51 13.29 0.47 9.17e-36 Lung cancer; BRCA cis rs9399137 0.507 rs6904897 chr6:135382980 T/G cg22676075 chr6:135203613 NA 0.41 8.27 0.31 7.76e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs17376456 0.597 rs7708175 chr5:93381182 A/G cg25358565 chr5:93447407 FAM172A -0.51 -9.15 -0.34 7.84e-19 Diabetic retinopathy; BRCA cis rs6964587 0.758 rs35963176 chr7:91617115 C/T cg17063962 chr7:91808500 NA 0.53 9.42 0.35 7.94e-20 Breast cancer; BRCA cis rs2645694 0.533 rs2703125 chr4:77819900 T/C cg06046430 chr4:77819534 ANKRD56 0.61 13.51 0.47 9.58e-37 Emphysema distribution in smoking; BRCA cis rs7766436 0.922 rs2066338 chr6:22611393 C/T cg13666174 chr6:22585274 NA -0.43 -9.21 -0.34 4.49e-19 Coronary artery disease; BRCA trans rs783540 0.681 rs1259178 chr15:83271876 T/C cg16105309 chr15:79090380 ADAMTS7 0.33 9.21 0.34 4.44e-19 Schizophrenia; BRCA cis rs7598759 0.527 rs4973417 chr2:232349636 G/T cg19187155 chr2:232395269 NMUR1 0.7 16.66 0.55 4.83e-52 Noise-induced hearing loss; BRCA cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg17971929 chr21:40555470 PSMG1 0.79 18.92 0.6 1.04e-63 Cognitive function; BRCA cis rs950169 0.579 rs11633088 chr15:84672181 A/T cg17507749 chr15:85114479 UBE2QP1 -0.53 -9.03 -0.34 1.93e-18 Schizophrenia; BRCA cis rs8180040 0.620 rs11707736 chr3:47069504 G/T cg27129171 chr3:47204927 SETD2 -0.73 -17.66 -0.57 3.78e-57 Colorectal cancer; BRCA cis rs3733585 0.673 rs10018204 chr4:9964570 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs765787 0.530 rs2413786 chr15:45525394 C/A cg24006582 chr15:45444508 DUOX1 -0.53 -10.88 -0.4 2e-25 Uric acid levels; BRCA cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg26031613 chr14:104095156 KLC1 -0.53 -9.42 -0.35 8.08e-20 Reticulocyte count; BRCA cis rs9814567 1.000 rs9289476 chr3:134237103 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.11 -0.34 1.08e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6831352 0.918 rs34071486 chr4:100051087 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7811142 1.000 rs6975514 chr7:100056220 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.82 -13.7 -0.48 1.17e-37 Platelet count; BRCA cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg11752832 chr7:134001865 SLC35B4 0.52 11.96 0.43 7.08e-30 Mean platelet volume; BRCA cis rs4332037 0.851 rs1403175 chr7:1964357 A/T cg23422044 chr7:1970798 MAD1L1 0.58 10.74 0.39 7.56e-25 Bipolar disorder; BRCA cis rs4819052 0.851 rs9754134 chr21:46661751 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.03 0.37 4.4e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg26677194 chr12:130822605 PIWIL1 0.6 14.55 0.5 1.23e-41 Menopause (age at onset); BRCA cis rs17401966 0.931 rs11121545 chr1:10411211 A/G cg19773385 chr1:10388646 KIF1B -0.38 -8.25 -0.31 8.98e-16 Hepatocellular carcinoma; BRCA cis rs8103278 1.000 rs7258283 chr19:46335511 C/T cg12641515 chr19:46296257 DMWD -0.54 -11.79 -0.42 3.57e-29 Coronary artery disease; BRCA cis rs3858526 0.834 rs10839166 chr11:6002464 T/C cg05234568 chr11:5960015 NA -0.45 -9.06 -0.34 1.56e-18 DNA methylation (variation); BRCA cis rs950027 0.620 rs1346267 chr15:45690989 A/G cg21132104 chr15:45694354 SPATA5L1 0.49 9.73 0.36 5.94e-21 Response to fenofibrate (adiponectin levels); BRCA cis rs9311474 0.967 rs11717383 chr3:52287468 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.27 8.39 0.31 3.2e-16 Electroencephalogram traits; BRCA cis rs9393692 0.645 rs6939048 chr6:26327953 G/A cg13736514 chr6:26305472 NA -0.45 -14.69 -0.5 2.79e-42 Educational attainment; BRCA cis rs7582720 1.000 rs4675310 chr2:203880834 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 -0.76 -12.37 -0.44 1.2e-31 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs3806843 0.900 rs2563279 chr5:140131535 G/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.24 0.34 3.56e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs13102973 1.000 rs4611981 chr4:135902585 C/T cg14419869 chr4:135874104 NA 0.48 9.97 0.37 7.55e-22 Subjective well-being; BRCA cis rs873946 0.517 rs7071784 chr10:134559980 T/C cg27286337 chr10:134555280 INPP5A 0.6 10.87 0.4 2.19e-25 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7267979 1.000 rs398036 chr20:25439850 C/T cg08601574 chr20:25228251 PYGB 0.33 8.05 0.3 4.14e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.712 rs1454648 chr21:45053815 C/T cg01579765 chr21:45077557 HSF2BP -0.44 -11.67 -0.42 1.14e-28 Mean corpuscular volume; BRCA cis rs7959452 0.527 rs4761157 chr12:69780907 A/G cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.97e-68 Blood protein levels; BRCA cis rs10045504 0.502 rs17352751 chr5:38737836 G/A cg15396434 chr5:38725168 NA -0.57 -11.05 -0.4 4.13e-26 Night sleep phenotypes; BRCA cis rs6484504 0.576 rs208071 chr11:31144996 C/T cg26647111 chr11:31128758 NA -0.43 -9.25 -0.34 3.43e-19 Red blood cell count; BRCA cis rs2836974 0.899 rs2836957 chr21:40623134 T/C cg11890956 chr21:40555474 PSMG1 1.05 29.55 0.76 1.2e-121 Cognitive function; BRCA cis rs698833 0.892 rs698796 chr2:44689669 C/A cg18685995 chr2:44588913 PREPL;C2orf34 0.5 10.36 0.38 2.25e-23 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs698833 0.962 rs698832 chr2:44734823 C/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.49 -10.02 -0.37 4.6e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7589728 0.563 rs80324973 chr2:88447264 T/G cg04511125 chr2:88470314 THNSL2 0.95 13.73 0.48 8.71e-38 Plasma clusterin levels; BRCA cis rs10504229 0.683 rs72650849 chr8:58140323 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA trans rs6598955 0.671 rs55791848 chr1:26582711 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs8180040 1.000 rs1076394 chr3:47322781 G/A cg16586182 chr3:47516702 SCAP 0.61 14.11 0.49 1.55e-39 Colorectal cancer; BRCA cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.42 8.51 0.32 1.23e-16 Personality dimensions; BRCA cis rs616402 0.527 rs604369 chr1:10567208 C/A cg17425144 chr1:10567563 PEX14 0.64 16.66 0.55 5e-52 Breast size; BRCA cis rs9926296 0.585 rs4785595 chr16:89835521 C/T cg07402062 chr16:89894098 SPIRE2 -0.28 -10.02 -0.37 4.59e-22 Vitiligo; BRCA cis rs7647973 1.000 rs7619789 chr3:49476263 T/C cg07636037 chr3:49044803 WDR6 0.76 16.5 0.55 3.36e-51 Menarche (age at onset); BRCA cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.09 -0.3 2.98e-15 Bipolar disorder; BRCA cis rs637571 0.584 rs594689 chr11:65635559 G/A cg26695010 chr11:65641043 EFEMP2 0.45 10.09 0.37 2.57e-22 Eosinophil percentage of white cells; BRCA trans rs3812049 0.784 rs2617617 chr5:127455008 C/T cg16011800 chr17:1958478 HIC1 -0.55 -8.85 -0.33 8.58e-18 Lymphocyte counts;Red cell distribution width; BRCA cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg24675658 chr1:53192096 ZYG11B -0.52 -11.44 -0.41 1.07e-27 Monocyte count; BRCA cis rs6543140 0.929 rs7602207 chr2:103032366 C/G cg04239558 chr2:103089729 SLC9A4 0.33 9.25 0.34 3.24e-19 Blood protein levels; BRCA cis rs9297145 0.724 rs6954584 chr7:98766930 G/A cg05967295 chr7:98741636 SMURF1 0.96 18.2 0.58 6.09e-60 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7772486 0.875 rs10457795 chr6:146415665 A/G cg13319975 chr6:146136371 FBXO30 -0.39 -8.75 -0.33 1.96e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs27434 0.583 rs151953 chr5:96157648 C/G cg16492584 chr5:96139282 ERAP1 -0.44 -10.96 -0.4 1.02e-25 Ankylosing spondylitis; BRCA cis rs2243480 1.000 rs160639 chr7:65579987 C/G cg18252515 chr7:66147081 NA -1.02 -14.91 -0.51 2.26e-43 Diabetic kidney disease; BRCA cis rs7520050 0.966 rs785491 chr1:46583418 G/A cg24296786 chr1:45957014 TESK2 0.41 9.11 0.34 1.03e-18 Red blood cell count;Reticulocyte count; BRCA cis rs9611519 0.929 rs73174660 chr22:41437304 T/C cg03806693 chr22:41940476 POLR3H -0.55 -9.66 -0.36 1.06e-20 Neuroticism; BRCA cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs4722585 0.533 rs6964215 chr7:26196819 G/A cg07876897 chr7:26191696 NFE2L3 0.39 8.29 0.31 6.94e-16 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg15839431 chr19:19639596 YJEFN3 -0.4 -8.71 -0.33 2.56e-17 Bipolar disorder; BRCA cis rs11608355 0.545 rs4766603 chr12:109892106 T/C cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs708547 0.915 rs28605409 chr4:57766261 A/G cg25525207 chr4:57843836 C4orf14;POLR2B -0.48 -8.31 -0.31 5.77e-16 Response to bleomycin (chromatid breaks); BRCA cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg25358565 chr5:93447407 FAM172A 1.17 18.44 0.59 3.18e-61 Diabetic retinopathy; BRCA cis rs1865721 0.958 rs72977878 chr18:73193037 T/G cg26385618 chr18:73139727 C18orf62 -0.39 -9.0 -0.34 2.66e-18 Intelligence; BRCA cis rs11098499 0.820 rs6829903 chr4:120506884 C/T cg09307838 chr4:120376055 NA 0.68 13.99 0.48 5.27e-39 Corneal astigmatism; BRCA cis rs12310956 0.532 rs11052952 chr12:33988048 G/A cg06521331 chr12:34319734 NA -0.62 -11.21 -0.41 9.26e-27 Morning vs. evening chronotype; BRCA cis rs4702 0.611 rs1894401 chr15:91429042 C/T cg05469396 chr15:91419421 FURIN 0.33 8.4 0.32 2.8e-16 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs9300255 0.739 rs6633 chr12:123745809 G/T cg00376283 chr12:123451042 ABCB9 -0.55 -10.84 -0.39 3.01e-25 Neutrophil percentage of white cells; BRCA trans rs3857536 0.813 rs9294688 chr6:66945904 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.39 -7.83 -0.3 2.02e-14 Blood trace element (Cu levels); BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.73 -0.33 2.29e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9325144 0.560 rs6582539 chr12:38630097 C/T cg13010199 chr12:38710504 ALG10B -0.41 -9.4 -0.35 9.44e-20 Morning vs. evening chronotype; BRCA cis rs4363385 0.720 rs1134220 chr1:152976306 T/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.46e-16 Inflammatory skin disease; BRCA cis rs9487051 0.768 rs461487 chr6:109525504 A/G cg21918786 chr6:109611834 NA -0.34 -9.05 -0.34 1.68e-18 Reticulocyte fraction of red cells; BRCA cis rs9309473 1.000 rs6705489 chr2:73648811 G/T cg20560298 chr2:73613845 ALMS1 -0.44 -10.69 -0.39 1.24e-24 Metabolite levels; BRCA cis rs10751667 0.666 rs4072741 chr11:976565 T/C cg01483505 chr11:975446 AP2A2 0.33 9.07 0.34 1.41e-18 Alzheimer's disease (late onset); BRCA cis rs6545883 0.894 rs2167566 chr2:61519408 G/T cg15711740 chr2:61764176 XPO1 -0.5 -12.53 -0.44 2.29e-32 Tuberculosis; BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg27170947 chr2:26402098 FAM59B -0.7 -11.65 -0.42 1.4e-28 Gut microbiome composition (summer); BRCA cis rs367943 1.000 rs348928 chr5:112815295 C/T cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg00814883 chr7:100076585 TSC22D4 -0.49 -9.4 -0.35 9.19e-20 Platelet count; BRCA cis rs1163251 0.756 rs539799 chr1:120208472 C/T cg19096424 chr1:120255104 PHGDH 0.34 7.91 0.3 1.16e-14 Blood metabolite levels; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg22963979 chr7:1858916 MAD1L1 -0.38 -8.17 -0.31 1.71e-15 Bipolar disorder and schizophrenia; BRCA cis rs9649465 1.000 rs3807634 chr7:123382290 C/T cg04330084 chr7:123175371 IQUB -0.32 -8.76 -0.33 1.72e-17 Migraine; BRCA cis rs4805272 0.539 rs1422212 chr19:29330191 T/A cg14983838 chr19:29218262 NA 0.48 8.12 0.31 2.4e-15 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg11833968 chr6:79620685 NA -0.39 -8.7 -0.33 2.76e-17 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg08045932 chr20:61659980 NA 0.49 11.15 0.4 1.75e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs79976124 0.837 rs12194087 chr6:66644399 T/A cg07460842 chr6:66804631 NA 0.62 11.13 0.4 2.1e-26 Type 2 diabetes; BRCA cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg17845761 chr1:175162550 KIAA0040 -0.26 -9.8 -0.36 3.31e-21 Alcohol dependence; BRCA cis rs3820928 0.874 rs12467261 chr2:227888838 T/C cg11843606 chr2:227700838 RHBDD1 -0.35 -7.88 -0.3 1.42e-14 Pulmonary function; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs11098499 0.663 rs28369503 chr4:120238925 G/A cg09307838 chr4:120376055 NA 0.63 13.59 0.47 3.72e-37 Corneal astigmatism; BRCA trans rs11039798 0.623 rs635632 chr11:48399532 T/C cg03929089 chr4:120376271 NA -0.53 -8.81 -0.33 1.21e-17 Axial length; BRCA cis rs7264396 1.000 rs7264396 chr20:34154741 A/G cg04508476 chr20:34239394 CPNE1;RBM12 0.43 8.97 0.33 3.24e-18 Total cholesterol levels; BRCA trans rs1005277 0.579 rs2474567 chr10:38382492 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.55 -0.32 8.98e-17 Extrinsic epigenetic age acceleration; BRCA cis rs4742903 1.000 rs7854630 chr9:106875277 A/C cg21169611 chr9:106856078 SMC2 -0.36 -9.28 -0.34 2.63e-19 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs1008375 1.000 rs17507481 chr4:17620066 A/G cg02297831 chr4:17616191 MED28 0.39 9.05 0.34 1.74e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs908922 0.676 rs10788842 chr1:152514588 A/T cg20991723 chr1:152506922 NA 0.39 8.95 0.33 3.87e-18 Hair morphology; BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.14 -0.31 2.02e-15 Total body bone mineral density; BRCA cis rs9814567 1.000 rs9289478 chr3:134268619 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.59 -0.61 2.67e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6430585 0.583 rs4988145 chr2:136632300 A/C cg07169764 chr2:136633963 MCM6 1.28 28.4 0.75 2.18e-115 Corneal structure; BRCA cis rs2075371 0.863 rs9641966 chr7:133961205 G/A cg11752832 chr7:134001865 SLC35B4 0.5 11.35 0.41 2.45e-27 Mean platelet volume; BRCA cis rs9325144 0.647 rs11169189 chr12:39097078 A/T cg26384229 chr12:38710491 ALG10B -0.46 -10.71 -0.39 9.72e-25 Morning vs. evening chronotype; BRCA cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg02574844 chr11:5959923 NA -0.42 -8.32 -0.31 5.27e-16 DNA methylation (variation); BRCA cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg23173402 chr1:227635558 NA 0.46 8.45 0.32 1.94e-16 Major depressive disorder; BRCA cis rs8180040 0.603 rs9854790 chr3:47101306 T/G cg16586182 chr3:47516702 SCAP -0.55 -12.43 -0.44 6.46e-32 Colorectal cancer; BRCA cis rs2645694 0.533 rs2703125 chr4:77819900 T/C cg10057126 chr4:77819792 ANKRD56 0.67 15.27 0.52 4.03e-45 Emphysema distribution in smoking; BRCA cis rs6089829 0.925 rs13041507 chr20:61666180 T/C cg08045932 chr20:61659980 NA 0.5 11.51 0.41 5.25e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs1577917 0.958 rs66807489 chr6:86440702 T/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.3 -7.85 -0.3 1.8e-14 Response to antipsychotic treatment; BRCA cis rs10504229 0.911 rs77203035 chr8:58175458 C/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9660180 0.620 rs3817856 chr1:1663831 C/T cg13866156 chr1:1669148 SLC35E2 0.51 10.8 0.39 4.33e-25 Body mass index; BRCA cis rs9858542 0.953 rs7623659 chr3:49414791 C/T cg03060546 chr3:49711283 APEH -0.51 -10.51 -0.38 6.34e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9640161 0.830 rs3735165 chr7:150068371 T/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.38 -9.62 -0.36 1.48e-20 Blood protein levels;Circulating chemerin levels; BRCA trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg15704280 chr7:45808275 SEPT13 -0.78 -17.34 -0.57 1.81e-55 Coronary artery disease; BRCA cis rs4332037 0.539 rs1533827 chr7:2074290 A/G cg02743256 chr7:2109353 MAD1L1 0.46 8.66 0.32 3.78e-17 Bipolar disorder; BRCA cis rs7593730 0.636 rs1020731 chr2:161144055 A/G cg22609984 chr2:161126801 NA -0.38 -7.84 -0.3 1.93e-14 Type 2 diabetes; BRCA cis rs9611565 0.694 rs106860 chr22:41840407 C/T cg19274703 chr22:41806451 NA 0.39 8.85 0.33 8.45e-18 Vitiligo; BRCA cis rs4561483 0.771 rs12924398 chr16:11972948 T/A cg08843971 chr16:11963173 GSPT1 -0.39 -8.17 -0.31 1.6e-15 Testicular germ cell tumor; BRCA trans rs9325144 0.600 rs10880934 chr12:38730455 C/T cg23762105 chr12:34175262 ALG10 0.37 8.52 0.32 1.17e-16 Morning vs. evening chronotype; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.64 -13.78 -0.48 5.18e-38 Lymphocyte counts; BRCA cis rs12474201 0.572 rs7596521 chr2:46918665 A/G cg06386533 chr2:46925753 SOCS5 0.51 9.89 0.36 1.44e-21 Height; BRCA cis rs1059312 1.000 rs9738216 chr12:129281788 C/T cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.66 -15.61 -0.53 9.03e-47 Systemic lupus erythematosus; BRCA cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.53 0.35 3.33e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs13047598 chr21:46660777 G/T cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9612 1.000 rs2074634 chr19:44238347 C/T cg08581076 chr19:44259116 C19orf61 -0.63 -11.45 -0.41 9.69e-28 Exhaled nitric oxide output; BRCA cis rs4803468 0.967 rs4802116 chr19:41905540 C/T cg09537434 chr19:41945824 ATP5SL -0.98 -24.01 -0.69 2.89e-91 Height; BRCA cis rs12142240 0.698 rs17357759 chr1:46832534 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.19 0.31 1.43e-15 Menopause (age at onset); BRCA cis rs7914558 0.966 rs3977751 chr10:104920232 A/G cg04362960 chr10:104952993 NT5C2 0.42 10.41 0.38 1.45e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs4728302 0.869 rs10155909 chr7:133593036 A/G cg07491979 chr7:133331646 EXOC4 0.36 7.89 0.3 1.31e-14 Intelligence;Intelligence (multi-trait analysis); BRCA trans rs7824557 0.767 rs4559208 chr8:11153925 C/G cg06636001 chr8:8085503 FLJ10661 0.53 10.22 0.37 8.37e-23 Retinal vascular caliber; BRCA trans rs2797160 0.967 rs1777182 chr6:126013614 T/A cg05039488 chr6:79577232 IRAK1BP1 0.35 7.89 0.3 1.36e-14 Endometrial cancer; BRCA cis rs9388451 0.807 rs1269175 chr6:126040435 A/G cg05901451 chr6:126070800 HEY2 0.57 14.79 0.51 8.35e-43 Brugada syndrome; BRCA cis rs3772130 0.583 rs7618041 chr3:121566481 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.39 0.49 7.2e-41 Cognitive performance; BRCA cis rs7618915 0.501 rs2079929 chr3:52765646 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.79 -0.42 3.6e-29 Bipolar disorder; BRCA cis rs425277 1.000 rs196128 chr1:2078444 T/G cg24578937 chr1:2090814 PRKCZ 0.57 17.81 0.58 6.82e-58 Height; BRCA cis rs6545883 0.894 rs2694642 chr2:61596180 A/G cg15711740 chr2:61764176 XPO1 0.51 12.44 0.44 5.81e-32 Tuberculosis; BRCA cis rs2404602 0.698 rs12909656 chr15:76664378 A/T cg23625390 chr15:77176239 SCAPER -0.52 -12.81 -0.45 1.33e-33 Blood metabolite levels; BRCA cis rs7246967 0.673 rs4933027 chr19:22903972 A/C cg23217946 chr19:22817039 ZNF492 -0.49 -9.24 -0.34 3.54e-19 Bronchopulmonary dysplasia; BRCA cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs4563143 0.577 rs73025093 chr19:29254618 T/G cg04546413 chr19:29218101 NA 0.65 12.1 0.43 1.64e-30 Methadone dose in opioid dependence; BRCA cis rs9649213 0.613 rs2286074 chr7:97952011 G/A cg21770322 chr7:97807741 LMTK2 0.41 10.97 0.4 8.81e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs12681288 0.676 rs2701923 chr8:994605 A/G cg04851639 chr8:1020857 NA -0.35 -10.12 -0.37 2.01e-22 Schizophrenia; BRCA cis rs832540 0.629 rs3309 chr5:56092779 A/T cg18230493 chr5:56204884 C5orf35 0.43 8.85 0.33 8.62e-18 Coronary artery disease; BRCA cis rs870825 0.616 rs28375770 chr4:185647395 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA trans rs7939886 0.920 rs17150038 chr11:55863414 A/T cg15704280 chr7:45808275 SEPT13 0.6 7.88 0.3 1.38e-14 Myopia (pathological); BRCA cis rs6952808 0.595 rs3778983 chr7:2166319 T/G cg02951883 chr7:2050386 MAD1L1 -0.57 -13.69 -0.48 1.31e-37 Bipolar disorder and schizophrenia; BRCA cis rs6545883 0.794 rs12053388 chr2:61532320 G/A cg15711740 chr2:61764176 XPO1 0.5 12.04 0.43 3.19e-30 Tuberculosis; BRCA cis rs7191700 0.674 rs12597893 chr16:11426331 A/G cg00044050 chr16:11439710 C16orf75 0.46 11.16 0.4 1.54e-26 Multiple sclerosis; BRCA cis rs12950390 0.776 rs4793646 chr17:45853966 A/C cg24803719 chr17:45855879 NA -0.31 -8.1 -0.31 2.77e-15 IgG glycosylation; BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.07 0.62 7.34e-70 Platelet count; BRCA cis rs6594499 0.872 rs10038058 chr5:110443281 A/G cg04022379 chr5:110408740 TSLP 0.36 8.2 0.31 1.31e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2841277 0.708 rs28600075 chr14:105408315 T/C cg19901468 chr14:105411992 AHNAK2 -0.51 -12.38 -0.44 1.03e-31 Rheumatoid arthritis; BRCA cis rs1008375 0.931 rs6813374 chr4:17649494 T/C cg02297831 chr4:17616191 MED28 0.38 8.9 0.33 5.66e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs8072100 0.754 rs8081717 chr17:45653921 T/A cg08085267 chr17:45401833 C17orf57 0.67 14.93 0.51 1.88e-43 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs736408 0.677 rs678 chr3:52820981 A/T cg18404041 chr3:52824283 ITIH1 -0.47 -14.0 -0.48 5.07e-39 Bipolar disorder; BRCA cis rs763121 0.853 rs2076028 chr22:39150450 G/A cg06022373 chr22:39101656 GTPBP1 0.71 16.0 0.53 1.03e-48 Menopause (age at onset); BRCA trans rs11098499 0.754 rs2036860 chr4:120248934 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.36 0.38 2.38e-23 Corneal astigmatism; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg04025307 chr7:1156635 C7orf50 0.74 18.81 0.6 3.93e-63 Longevity;Endometriosis; BRCA trans rs3733585 0.673 rs7375587 chr4:9954758 A/T cg26043149 chr18:55253948 FECH 0.37 8.18 0.31 1.57e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs868036 1.000 rs868037 chr15:68054996 A/G cg08079166 chr15:68083412 MAP2K5 -0.33 -8.68 -0.32 3.23e-17 Restless legs syndrome; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg22907277 chr7:1156413 C7orf50 0.59 9.1 0.34 1.11e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10751667 0.961 rs7943115 chr11:973885 T/C cg10932868 chr11:921992 NA 0.39 9.34 0.35 1.64e-19 Alzheimer's disease (late onset); BRCA cis rs34779708 0.897 rs35784065 chr10:35353574 C/T cg03585969 chr10:35415529 CREM 0.55 11.41 0.41 1.41e-27 Inflammatory bowel disease;Crohn's disease; BRCA trans rs61931739 0.500 rs10844862 chr12:34531965 A/T cg26384229 chr12:38710491 ALG10B 0.59 13.52 0.47 8.1e-37 Morning vs. evening chronotype; BRCA cis rs12458462 0.892 rs2007483 chr18:77476131 A/T cg11879182 chr18:77439856 CTDP1 0.59 12.64 0.45 7.58e-33 Monocyte count; BRCA cis rs11992186 0.597 rs77717027 chr8:8591632 T/C cg06636001 chr8:8085503 FLJ10661 -0.43 -8.85 -0.33 8.54e-18 Neuroticism; BRCA cis rs4363385 0.818 rs407448 chr1:153007504 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -8.92 -0.33 4.73e-18 Inflammatory skin disease; BRCA cis rs10254118 0.757 rs6467491 chr7:133138761 A/G cg10665199 chr7:133106180 EXOC4 0.48 10.16 0.37 1.42e-22 Intelligence (multi-trait analysis); BRCA cis rs514406 0.929 rs2607095 chr1:53325639 T/C cg25767906 chr1:53392781 SCP2 -0.38 -8.61 -0.32 5.89e-17 Monocyte count; BRCA cis rs9649213 0.593 rs7781916 chr7:97929738 A/G cg21770322 chr7:97807741 LMTK2 0.42 11.27 0.41 5.33e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2806561 0.894 rs629107 chr1:23537971 C/T cg19743168 chr1:23544995 NA 0.46 11.45 0.41 1.01e-27 Height; BRCA trans rs6951245 0.554 rs75075857 chr7:1140298 C/T cg13565492 chr6:43139072 SRF -0.88 -16.2 -0.54 1.08e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9381040 0.655 rs7775972 chr6:41038116 A/C cg03644281 chr6:41068752 NFYA;LOC221442 -0.43 -8.95 -0.33 3.89e-18 Alzheimer's disease (late onset); BRCA cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg23029597 chr12:123009494 RSRC2 -0.59 -11.49 -0.41 6.43e-28 Body mass index; BRCA cis rs12541635 0.677 rs2163124 chr8:107058862 G/T cg10147462 chr8:107024639 NA 0.4 10.75 0.39 7.04e-25 Age of smoking initiation; BRCA trans rs61931739 0.929 rs1825358 chr12:34011895 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.43 -0.35 7.61e-20 Morning vs. evening chronotype; BRCA trans rs3733585 0.673 rs4697914 chr4:9952266 G/A cg26043149 chr18:55253948 FECH -0.37 -8.14 -0.31 2.06e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2153535 0.505 rs9405395 chr6:8468622 T/A cg21535247 chr6:8435926 SLC35B3 0.39 8.73 0.33 2.22e-17 Motion sickness; BRCA cis rs8017423 0.935 rs7154695 chr14:90795705 C/G cg14092571 chr14:90743983 NA -0.34 -8.02 -0.3 5.07e-15 Mortality in heart failure; BRCA cis rs6951245 0.554 rs58210047 chr7:1149381 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.61 -11.48 -0.41 7.48e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9868809 0.505 rs28567949 chr3:48744560 G/A cg00383909 chr3:49044727 WDR6 0.58 10.53 0.38 4.92e-24 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs798554 0.567 rs2527695 chr7:2858267 T/G cg09658497 chr7:2847517 GNA12 -0.4 -8.6 -0.32 6.26e-17 Height; BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA trans rs2204008 0.811 rs8189445 chr12:38276295 T/C cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Bladder cancer; BRCA cis rs6088580 0.634 rs4911153 chr20:32961547 C/T cg24642439 chr20:33292090 TP53INP2 -0.51 -11.24 -0.41 6.81e-27 Glomerular filtration rate (creatinine); BRCA cis rs4974559 0.947 rs10018627 chr4:1356358 G/A cg02980000 chr4:1222292 CTBP1 0.75 12.66 0.45 6.36e-33 Systolic blood pressure; BRCA cis rs523522 0.962 rs10774549 chr12:120891172 C/T cg27279351 chr12:120934652 DYNLL1 0.57 13.17 0.46 3.18e-35 High light scatter reticulocyte count; BRCA cis rs6545883 0.868 rs7574631 chr2:61825142 T/G cg15711740 chr2:61764176 XPO1 -0.55 -14.01 -0.48 4.49e-39 Tuberculosis; BRCA cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg01475377 chr6:109611718 NA -0.6 -16.64 -0.55 6.57e-52 Reticulocyte fraction of red cells; BRCA cis rs7819412 0.595 rs10106914 chr8:10987651 T/G cg21775007 chr8:11205619 TDH -0.48 -10.06 -0.37 3.43e-22 Triglycerides; BRCA cis rs2304069 0.954 rs9324638 chr5:149400718 A/G cg10852222 chr5:149380144 HMGXB3;TIGD6 -0.56 -8.66 -0.32 3.92e-17 HIV-1 control; BRCA cis rs1059312 0.772 rs11609637 chr12:129300202 T/G cg09035930 chr12:129282057 SLC15A4 0.48 13.49 0.47 1.07e-36 Systemic lupus erythematosus; BRCA cis rs17209837 0.607 rs4148810 chr7:87102251 C/T cg00919237 chr7:87102261 ABCB4 -0.53 -10.23 -0.38 7.27e-23 Gallbladder cancer; BRCA cis rs8072100 0.764 rs2644349 chr17:45641743 G/A cg25173405 chr17:45401733 C17orf57 0.47 9.77 0.36 4.26e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.37 -0.38 2.13e-23 Intelligence (multi-trait analysis); BRCA cis rs9868809 0.505 rs56735597 chr3:48765168 A/G cg07636037 chr3:49044803 WDR6 -0.6 -8.15 -0.31 1.97e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs7395581 0.918 rs11039166 chr11:47316691 A/C cg25783544 chr11:47291846 MADD 0.43 9.76 0.36 4.54e-21 HDL cholesterol; BRCA cis rs1568889 0.877 rs57202579 chr11:28221677 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.61 0.5 6.33e-42 Bipolar disorder; BRCA cis rs1008375 0.897 rs1006723 chr4:17618524 G/A cg15017067 chr4:17643749 FAM184B 0.29 8.93 0.33 4.45e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1580019 0.587 rs6968990 chr7:32552159 C/T cg14728415 chr7:32535168 LSM5;AVL9 -0.4 -8.89 -0.33 6.15e-18 Cognitive ability; BRCA cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg01939980 chr4:1354348 KIAA1530 0.31 8.47 0.32 1.62e-16 Obesity-related traits; BRCA cis rs4665809 0.838 rs6546749 chr2:26306288 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.76 -13.23 -0.46 1.74e-35 Gut microbiome composition (summer); BRCA cis rs7178424 1.000 rs4564516 chr15:62365107 G/C cg00456672 chr15:62358751 C2CD4A -0.35 -8.44 -0.32 2.2e-16 Height; BRCA cis rs12618769 0.597 rs4850874 chr2:99069799 G/A cg10123293 chr2:99228465 UNC50 0.41 8.18 0.31 1.57e-15 Bipolar disorder; BRCA trans rs1997103 1.000 rs2331068 chr7:55408220 G/A cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg18446336 chr7:2847575 GNA12 -0.42 -10.41 -0.38 1.56e-23 Plateletcrit; BRCA trans rs11098499 0.865 rs2389809 chr4:120377399 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.3e-14 Corneal astigmatism; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg05552183 chr6:42928497 GNMT 0.66 14.13 0.49 1.2e-39 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7011049 1.000 rs72643580 chr8:53846710 T/G cg26025543 chr8:53854495 NA 0.55 9.57 0.35 2.31e-20 Systolic blood pressure; BRCA cis rs60871478 0.636 rs6976929 chr7:901382 C/T cg27478167 chr7:817139 HEATR2 0.52 10.18 0.37 1.17e-22 Cerebrospinal P-tau181p levels; BRCA cis rs35110281 0.659 rs11702544 chr21:45091861 C/T cg01579765 chr21:45077557 HSF2BP -0.44 -11.99 -0.43 5.11e-30 Mean corpuscular volume; BRCA trans rs9325144 0.555 rs4550281 chr12:38689937 A/G cg23762105 chr12:34175262 ALG10 -0.4 -9.76 -0.36 4.39e-21 Morning vs. evening chronotype; BRCA cis rs2070488 1.000 rs762317 chr3:38497659 A/G cg24069376 chr3:38537580 EXOG 0.42 12.09 0.43 1.85e-30 Electrocardiographic conduction measures; BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.03 -0.43 3.49e-30 Gut microbiome composition (summer); BRCA cis rs8005677 1.000 rs8016061 chr14:23375809 A/G cg01529538 chr14:23388837 RBM23 0.42 11.56 0.42 3.3e-28 Cognitive ability (multi-trait analysis); BRCA cis rs7582180 0.627 rs4851312 chr2:101011241 G/A cg14675211 chr2:100938903 LONRF2 0.43 9.62 0.36 1.54e-20 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg06238570 chr21:40685208 BRWD1 0.43 8.59 0.32 6.55e-17 Cognitive function; BRCA cis rs9467773 1.000 rs1321481 chr6:26538210 A/T cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs11608355 0.545 rs36094325 chr12:109911542 A/T cg05360138 chr12:110035743 NA 0.71 13.05 0.46 1.09e-34 Neuroticism; BRCA cis rs10504229 0.679 rs111843870 chr8:58126798 A/G cg24829409 chr8:58192753 C8orf71 -0.48 -9.14 -0.34 7.94e-19 Developmental language disorder (linguistic errors); BRCA cis rs11809207 0.574 rs2783633 chr1:26505265 A/G cg23602478 chr1:26503979 CNKSR1 0.23 7.95 0.3 8.44e-15 Height; BRCA cis rs2425143 0.818 rs35448195 chr20:34542365 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.97 -0.3 7.27e-15 Blood protein levels; BRCA trans rs9329221 0.662 rs11249996 chr8:10245463 G/T cg15556689 chr8:8085844 FLJ10661 -0.34 -8.49 -0.32 1.39e-16 Neuroticism; BRCA cis rs6831352 0.959 rs6848050 chr4:100053733 T/C cg13256891 chr4:100009986 ADH5 0.47 9.06 0.34 1.52e-18 Alcohol dependence; BRCA cis rs2289583 0.642 rs67624860 chr15:75391557 A/G cg14664628 chr15:75095509 CSK 0.39 9.09 0.34 1.26e-18 Systemic lupus erythematosus; BRCA cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg20503657 chr10:835505 NA 1.31 21.75 0.65 6.72e-79 Eosinophil percentage of granulocytes; BRCA cis rs3862030 0.839 rs7078679 chr10:104284017 C/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.03 -0.43 3.53e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs6748734 1.000 rs4311055 chr2:241821017 T/C cg02820040 chr2:241836501 C2orf54 -0.52 -9.99 -0.37 5.96e-22 Urinary metabolites; BRCA cis rs7613875 0.578 rs4688753 chr3:50074773 A/G cg14019146 chr3:50243930 SLC38A3 0.36 8.96 0.33 3.53e-18 Body mass index; BRCA cis rs2070433 1.000 rs2839306 chr21:47954219 G/T cg05998816 chr21:47859926 PCNT -0.34 -8.24 -0.31 9.85e-16 Lymphocyte counts; BRCA trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg17830980 chr10:43048298 ZNF37B 0.56 13.61 0.47 3.18e-37 Extrinsic epigenetic age acceleration; BRCA cis rs2637266 1.000 rs7098790 chr10:78361077 T/A cg18941641 chr10:78392320 NA 0.35 7.84 0.3 1.83e-14 Pulmonary function; BRCA trans rs61931739 0.500 rs7489130 chr12:34539674 C/A cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs7481584 0.669 rs12421922 chr11:3035070 A/G cg25174290 chr11:3078921 CARS -0.3 -8.02 -0.3 5.12e-15 Calcium levels; BRCA cis rs769267 0.965 rs2315025 chr19:19426609 C/T cg19010396 chr19:19431384 KIAA0892;SF4 0.48 9.85 0.36 2.13e-21 Tonsillectomy; BRCA cis rs1005277 0.579 rs2505237 chr10:38438898 T/G cg00409905 chr10:38381863 ZNF37A -0.51 -10.92 -0.4 1.44e-25 Extrinsic epigenetic age acceleration; BRCA cis rs2624839 0.704 rs12637671 chr3:50224562 G/A cg05623727 chr3:50126028 RBM5 -0.37 -8.14 -0.31 2.01e-15 Intelligence (multi-trait analysis); BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs6700896 0.931 rs12034502 chr1:66099831 C/T cg04111102 chr1:66153794 NA 0.33 8.23 0.31 1.09e-15 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7524258 0.868 rs2157499 chr1:7271472 C/T cg07173049 chr1:7289937 CAMTA1 0.45 11.06 0.4 3.85e-26 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg04025307 chr7:1156635 C7orf50 0.59 9.45 0.35 6.35e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs700651 0.789 rs2196176 chr2:198904914 A/G cg00792783 chr2:198669748 PLCL1 0.38 8.41 0.32 2.7e-16 Intracranial aneurysm; BRCA cis rs11190604 1.000 rs10883493 chr10:102208188 A/T cg07080220 chr10:102295463 HIF1AN 0.49 11.33 0.41 2.98e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7000551 0.689 rs10110254 chr8:22309551 G/T cg12081754 chr8:22256438 SLC39A14 0.42 8.24 0.31 9.78e-16 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs4727443 0.899 rs886453 chr7:99588225 G/A cg22004693 chr7:99632812 ZKSCAN1 0.39 8.84 0.33 9.53e-18 Interstitial lung disease; BRCA trans rs2562456 1.000 rs2562456 chr19:21666210 A/G cg25042112 chr7:64838748 ZNF92 -0.42 -8.32 -0.31 5.3e-16 Pain; BRCA trans rs6076960 0.623 rs6038407 chr20:6267326 A/G cg21095983 chr6:86352623 SYNCRIP 0.46 9.89 0.36 1.46e-21 Smooth-surface caries; BRCA cis rs10751667 0.643 rs10751669 chr11:942344 C/G ch.11.42038R chr11:967971 AP2A2 -0.5 -15.8 -0.53 1.02e-47 Alzheimer's disease (late onset); BRCA cis rs6879260 1.000 rs1035411 chr5:179729519 A/G cg23248424 chr5:179741104 GFPT2 -0.66 -13.57 -0.47 4.84e-37 Height; BRCA cis rs36051895 0.659 rs12351277 chr9:5061405 A/C cg02405213 chr9:5042618 JAK2 -0.5 -9.18 -0.34 6.1e-19 Pediatric autoimmune diseases; BRCA cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg12292205 chr6:26970375 C6orf41 0.72 16.4 0.54 1.09e-50 Autism spectrum disorder or schizophrenia; BRCA cis rs4727027 0.704 rs12535115 chr7:148895087 C/T cg23583168 chr7:148888333 NA -0.97 -26.31 -0.72 5.93e-104 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 11.03 0.4 5.12e-26 Height; BRCA cis rs4820294 1.000 rs62236668 chr22:38063870 G/A cg21798802 chr22:38057573 PDXP 0.49 13.22 0.46 2.02e-35 Fat distribution (HIV); BRCA cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs6545883 0.507 rs2442025 chr2:61571445 G/A cg15711740 chr2:61764176 XPO1 0.31 7.81 0.3 2.29e-14 Tuberculosis; BRCA trans rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.01e-14 Endometrial cancer; BRCA cis rs10504229 0.775 rs17805146 chr8:58161484 G/A cg08280861 chr8:58055591 NA 0.53 8.59 0.32 6.53e-17 Developmental language disorder (linguistic errors); BRCA cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.56 0.42 3.26e-28 Rheumatoid arthritis; BRCA cis rs16976116 0.855 rs11856010 chr15:55495008 A/G cg11288833 chr15:55489084 RSL24D1 0.48 10.68 0.39 1.25e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs476633 0.691 rs11858115 chr15:41542591 G/A cg18705301 chr15:41695430 NDUFAF1 -0.4 -8.79 -0.33 1.42e-17 Glomerular filtration rate (creatinine); BRCA cis rs7552404 0.960 rs61797339 chr1:76189946 G/T cg22875332 chr1:76189707 ACADM 0.69 14.65 0.5 4.09e-42 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs4332037 0.575 rs55952733 chr7:2070680 G/A cg11693508 chr17:37793320 STARD3 0.57 10.81 0.39 4.14e-25 Bipolar disorder; BRCA cis rs11723261 0.621 rs6599307 chr4:143777 C/T cg12746427 chr4:53362 ZNF718;ZNF595 0.32 7.98 0.3 6.56e-15 Immune response to smallpox vaccine (IL-6); BRCA cis rs9463078 0.547 rs1338908 chr6:44728812 C/T cg25276700 chr6:44698697 NA 0.36 8.29 0.31 6.81e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1336900 0.637 rs35967040 chr1:150555588 A/C cg17724175 chr1:150552817 MCL1 -0.34 -11.05 -0.4 4.22e-26 Blood protein levels; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg04267008 chr7:1944627 MAD1L1 -0.57 -12.59 -0.45 1.32e-32 Bipolar disorder and schizophrenia; BRCA cis rs2249625 0.584 rs2496506 chr6:72891324 A/C cg18830697 chr6:72922368 RIMS1 -0.63 -14.34 -0.49 1.19e-40 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs8180040 0.620 rs1811652 chr3:47208698 C/G cg16586182 chr3:47516702 SCAP 0.56 12.51 0.44 2.85e-32 Colorectal cancer; BRCA cis rs6088580 0.634 rs4911418 chr20:32994257 G/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.68 -0.32 3.33e-17 Glomerular filtration rate (creatinine); BRCA cis rs7666738 0.830 rs13328042 chr4:99055406 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.95 0.4 1.12e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs3768617 0.510 rs7414273 chr1:183075017 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.43e-58 Fuchs's corneal dystrophy; BRCA cis rs2354432 0.607 rs7545467 chr1:146746248 A/G cg25205988 chr1:146714368 CHD1L -0.95 -12.44 -0.44 5.87e-32 Mitochondrial DNA levels; BRCA cis rs11676348 0.846 rs7594532 chr2:219008000 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.39 -8.2 -0.31 1.29e-15 Ulcerative colitis; BRCA cis rs6701037 0.566 rs1014555 chr1:175134249 C/T cg17845761 chr1:175162550 KIAA0040 0.26 9.91 0.37 1.19e-21 Alcohol dependence; BRCA cis rs10465746 0.570 rs6658559 chr1:84467412 A/G cg10977910 chr1:84465055 TTLL7 0.54 11.07 0.4 3.53e-26 Obesity-related traits; BRCA cis rs13064411 0.597 rs2291905 chr3:113010466 C/T cg18753928 chr3:113234510 CCDC52 -0.42 -9.01 -0.34 2.44e-18 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs3091242 0.934 rs666686 chr1:25719511 A/G cg23205692 chr1:25664452 TMEM50A 0.4 9.83 0.36 2.5e-21 Erythrocyte sedimentation rate; BRCA cis rs2070488 0.695 rs6599201 chr3:38476614 A/G cg24069376 chr3:38537580 EXOG 0.32 9.04 0.34 1.78e-18 Electrocardiographic conduction measures; BRCA cis rs9291683 0.510 rs4318649 chr4:10016815 T/C cg00071950 chr4:10020882 SLC2A9 0.58 14.11 0.49 1.55e-39 Bone mineral density; BRCA cis rs614226 0.872 rs787827 chr12:120937794 A/G cg01236616 chr12:121019343 POP5 1.24 27.07 0.73 4.13e-108 Type 1 diabetes nephropathy; BRCA cis rs9733 0.744 rs12125650 chr1:150760174 A/G cg18016565 chr1:150552671 MCL1 -0.37 -8.58 -0.32 7.01e-17 Tonsillectomy; BRCA cis rs2645694 0.626 rs2645709 chr4:77824474 G/A cg06046430 chr4:77819534 ANKRD56 0.62 14.02 0.49 3.92e-39 Emphysema distribution in smoking; BRCA trans rs2898290 0.592 rs2736342 chr8:11347289 A/C cg08975724 chr8:8085496 FLJ10661 -0.36 -7.88 -0.3 1.44e-14 Systolic blood pressure; BRCA cis rs10267417 0.544 rs2072185 chr7:19748700 G/A cg07541023 chr7:19748670 TWISTNB 0.98 21.43 0.65 3.65e-77 Night sleep phenotypes; BRCA cis rs870825 0.616 rs6552809 chr4:185643984 G/A cg04058563 chr4:185651563 MLF1IP 0.76 17.12 0.56 2.3e-54 Blood protein levels; BRCA cis rs2762353 0.808 rs1165150 chr6:25842032 C/T cg03264133 chr6:25882463 NA -0.53 -11.99 -0.43 5.08e-30 Blood metabolite levels; BRCA cis rs367943 1.000 rs348961 chr5:112819944 A/C cg12552261 chr5:112820674 MCC -0.59 -12.24 -0.44 4.35e-31 Type 2 diabetes; BRCA cis rs9790314 0.663 rs10513562 chr3:160743579 G/A cg03342759 chr3:160939853 NMD3 -0.44 -9.13 -0.34 8.97e-19 Morning vs. evening chronotype; BRCA trans rs7824557 0.724 rs2572398 chr8:11178093 A/C cg14343924 chr8:8086146 FLJ10661 0.39 7.86 0.3 1.59e-14 Retinal vascular caliber; BRCA cis rs11711311 1.000 rs7649590 chr3:113447267 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.31 7.9 0.3 1.24e-14 IgG glycosylation; BRCA cis rs490234 0.783 rs28729336 chr9:128405488 T/G cg14078157 chr9:128172775 NA -0.47 -10.65 -0.39 1.76e-24 Mean arterial pressure; BRCA cis rs7786877 0.521 rs4729606 chr7:100321790 T/C cg16850897 chr7:100343110 ZAN -0.62 -12.88 -0.45 6.75e-34 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg01028140 chr2:1542097 TPO -0.77 -15.23 -0.52 6.2e-45 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6088590 0.965 rs910869 chr20:33292777 C/T cg06115741 chr20:33292138 TP53INP2 0.53 11.64 0.42 1.57e-28 Coronary artery disease; BRCA cis rs9287719 0.601 rs10178751 chr2:10734203 T/C cg00105475 chr2:10696890 NA 0.41 9.26 0.34 3e-19 Prostate cancer; BRCA cis rs3820928 0.647 rs2115597 chr2:227791218 T/C cg11843606 chr2:227700838 RHBDD1 -0.5 -11.37 -0.41 2.05e-27 Pulmonary function; BRCA cis rs12497850 0.864 rs4955410 chr3:49181218 A/G cg07636037 chr3:49044803 WDR6 0.95 26.92 0.73 2.75e-107 Parkinson's disease; BRCA cis rs1008375 0.902 rs7654332 chr4:17691778 A/T cg04450456 chr4:17643702 FAM184B 0.32 9.34 0.35 1.5700000000000001e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9858542 0.953 rs6766131 chr3:49538932 T/C cg03060546 chr3:49711283 APEH -0.54 -10.99 -0.4 7.38e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.43 8.25 0.31 9.14e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8031584 0.706 rs798084 chr15:31126935 C/T cg14298792 chr15:30685198 CHRFAM7A -0.44 -8.08 -0.3 3.15e-15 Huntington's disease progression; BRCA trans rs9784649 1.000 rs56205870 chr5:24958870 A/G cg08600765 chr20:34638493 LOC647979 -0.5 -8.15 -0.31 1.96e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg21280719 chr6:42927975 GNMT -0.31 -13.23 -0.46 1.68e-35 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs3820928 0.874 rs56324594 chr2:227868854 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.29 -0.31 6.54e-16 Pulmonary function; BRCA cis rs2991971 0.967 rs512026 chr1:46009946 G/T cg24296786 chr1:45957014 TESK2 0.65 16.16 0.54 1.65e-49 High light scatter reticulocyte count; BRCA cis rs1371614 0.632 rs6718978 chr2:27161591 G/A cg00617064 chr2:27272375 NA -0.3 -7.91 -0.3 1.15e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs10465746 0.725 rs980417 chr1:84365331 C/A cg10977910 chr1:84465055 TTLL7 0.59 12.66 0.45 6.17e-33 Obesity-related traits; BRCA cis rs763121 0.853 rs5750659 chr22:39068789 T/C cg21395723 chr22:39101663 GTPBP1 0.39 8.33 0.31 4.9e-16 Menopause (age at onset); BRCA cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.93 0.37 1.05e-21 Bipolar disorder; BRCA trans rs6952808 0.689 rs2008263 chr7:2048335 A/G cg04565464 chr8:145669602 NFKBIL2 0.33 8.06 0.3 3.66e-15 Bipolar disorder and schizophrenia; BRCA cis rs1707322 0.752 rs12062535 chr1:46222880 G/A cg06784218 chr1:46089804 CCDC17 0.5 11.95 0.43 7.46e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9287719 0.934 rs6432115 chr2:10748343 G/T cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.28e-23 Prostate cancer; BRCA cis rs17641971 0.619 rs6983929 chr8:49984896 T/C cg00325661 chr8:49890786 NA 0.37 10.47 0.38 8.86e-24 Blood metabolite levels; BRCA cis rs6701037 0.681 rs6664840 chr1:175128726 A/G cg14847009 chr1:175162515 KIAA0040 -0.25 -9.47 -0.35 5.44e-20 Alcohol dependence; BRCA cis rs2235642 0.507 rs2235643 chr16:1585115 A/G cg03034668 chr16:1723424 CRAMP1L 0.44 9.41 0.35 8.48e-20 Coronary artery disease; BRCA cis rs7727544 0.735 rs272894 chr5:131662460 C/T cg07395648 chr5:131743802 NA -0.36 -9.09 -0.34 1.25e-18 Blood metabolite levels; BRCA cis rs10504229 0.728 rs72650860 chr8:58153111 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs6088580 0.609 rs6059845 chr20:33036500 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.6 0.32 6.04e-17 Glomerular filtration rate (creatinine); BRCA cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs72480748 0.509 rs3865457 chr19:41398969 C/T cg04176888 chr19:41596066 CYP2A13 0.3 8.13 0.31 2.16e-15 Post bronchodilator FEV1;Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio); BRCA cis rs7833790 0.700 rs28390260 chr8:82769175 A/T cg27398817 chr8:82754497 SNX16 0.35 8.0 0.3 5.8e-15 Diastolic blood pressure; BRCA cis rs7607369 0.536 rs7566656 chr2:219664519 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.22 -0.37 8.27e-23 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg03929089 chr4:120376271 NA 0.5 8.24 0.31 9.49e-16 Axial length; BRCA cis rs1707322 0.656 rs9429172 chr1:46092476 C/G cg06784218 chr1:46089804 CCDC17 -0.52 -12.53 -0.44 2.37e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs701145 0.585 rs1727887 chr3:153839465 G/T cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs4566357 1.000 rs6436649 chr2:227923952 A/G cg11843606 chr2:227700838 RHBDD1 -0.37 -7.81 -0.3 2.43e-14 Coronary artery disease; BRCA cis rs1552244 1.000 rs17032283 chr3:10081545 C/G cg08888203 chr3:10149979 C3orf24 0.64 13.7 0.48 1.16e-37 Alzheimer's disease; BRCA cis rs875971 1.000 rs2042133 chr7:65931922 A/G cg11764359 chr7:65958608 NA 0.79 19.31 0.61 8.49e-66 Aortic root size; BRCA cis rs36051895 0.632 rs10974980 chr9:5140671 C/G cg02405213 chr9:5042618 JAK2 -0.51 -9.28 -0.34 2.51e-19 Pediatric autoimmune diseases; BRCA cis rs10493773 0.502 rs12066742 chr1:86081149 A/G cg17807903 chr1:86174739 ZNHIT6 -0.41 -8.49 -0.32 1.47e-16 Urate levels in overweight individuals; BRCA cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg27286337 chr10:134555280 INPP5A 0.64 11.36 0.41 2.38e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs61931739 0.534 rs10844840 chr12:34364517 C/T cg26384229 chr12:38710491 ALG10B 0.74 16.32 0.54 2.74e-50 Morning vs. evening chronotype; BRCA cis rs933688 1.000 rs1964292 chr5:90743608 T/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.65 0.61 1.3e-67 Smoking behavior; BRCA cis rs6840360 0.615 rs66852535 chr4:152472227 C/A cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs9420 0.961 rs11602109 chr11:57435296 G/A cg19752551 chr11:57585705 CTNND1 -0.5 -12.3 -0.44 2.36e-31 Schizophrenia; BRCA cis rs35146811 0.961 rs11771139 chr7:99736059 C/T cg22906224 chr7:99728672 NA 0.46 8.66 0.32 3.97e-17 Coronary artery disease; BRCA cis rs6570726 0.689 rs411785 chr6:145888398 G/A cg05347473 chr6:146136440 FBXO30 0.43 8.74 0.33 1.98e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.715 rs17221456 chr10:1037234 T/C cg20503657 chr10:835505 NA 0.99 15.06 0.51 4.16e-44 Eosinophil percentage of granulocytes; BRCA cis rs593982 0.858 rs537385 chr11:65504900 G/A cg08755490 chr11:65554678 OVOL1 1.27 29.33 0.76 1.95e-120 Atopic dermatitis; BRCA cis rs6088590 0.687 rs6088582 chr20:33286798 G/A cg24642439 chr20:33292090 TP53INP2 0.61 13.43 0.47 2.19e-36 Coronary artery disease; BRCA cis rs9300255 0.770 rs28683528 chr12:123845351 C/T cg00376283 chr12:123451042 ABCB9 -0.49 -11.35 -0.41 2.63e-27 Neutrophil percentage of white cells; BRCA cis rs10751667 0.600 rs10794342 chr11:924904 C/T cg01483505 chr11:975446 AP2A2 0.31 8.31 0.31 5.63e-16 Alzheimer's disease (late onset); BRCA trans rs6479891 0.908 rs2616631 chr10:65207914 T/A cg14819942 chr15:35414228 NA 0.35 8.55 0.32 8.9e-17 Arthritis (juvenile idiopathic); BRCA cis rs6878727 0.665 rs698185 chr5:123664565 A/G cg01806427 chr5:123737813 NA 0.35 7.97 0.3 7.26e-15 Breast cancer; BRCA cis rs17095355 0.818 rs61881639 chr10:111863501 G/A cg00817464 chr10:111662876 XPNPEP1 -0.43 -9.01 -0.34 2.36e-18 Biliary atresia; BRCA cis rs12367572 0.623 rs10880718 chr12:45362806 G/C cg04608330 chr12:45269318 NELL2 -0.47 -10.33 -0.38 3.05e-23 Gut microbiome composition (summer); BRCA trans rs4718428 0.705 rs12698547 chr7:66278258 T/C cg18876405 chr7:65276391 NA 0.44 8.49 0.32 1.45e-16 Corneal structure; BRCA cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.722 rs10410588 chr19:38042410 C/G cg23950597 chr19:37808831 NA -0.5 -8.58 -0.32 7.44e-17 Coronary artery calcification; BRCA cis rs10504229 0.683 rs17194792 chr8:58107195 A/C cg24829409 chr8:58192753 C8orf71 -0.51 -8.32 -0.31 5.35e-16 Developmental language disorder (linguistic errors); BRCA cis rs11676348 0.755 rs6436026 chr2:218951738 T/A cg20019365 chr2:219134978 PNKD;AAMP -0.39 -8.14 -0.31 2.04e-15 Ulcerative colitis; BRCA cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg04586622 chr2:25135609 ADCY3 0.43 10.77 0.39 5.87e-25 Body mass index; BRCA cis rs1865760 0.566 rs1539183 chr6:26075051 G/C cg16482183 chr6:26056742 HIST1H1C 0.54 11.56 0.42 3.44e-28 Height; BRCA cis rs2991971 0.934 rs11211129 chr1:45983080 C/T cg24296786 chr1:45957014 TESK2 0.65 15.98 0.53 1.25e-48 High light scatter reticulocyte count; BRCA cis rs73086581 1.000 rs34640283 chr20:3989576 T/A cg02187196 chr20:3869020 PANK2 0.53 9.34 0.35 1.6e-19 Response to antidepressants in depression; BRCA cis rs1371614 0.566 rs10203050 chr2:27186561 C/T cg00617064 chr2:27272375 NA 0.31 8.05 0.3 4.2e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9309711 0.643 rs10188449 chr2:3480366 T/C cg10845886 chr2:3471009 TTC15 -0.54 -12.17 -0.43 8.44e-31 Neurofibrillary tangles; BRCA cis rs7523273 0.586 rs2724359 chr1:207935706 A/G cg22525895 chr1:207977042 MIR29B2 0.47 12.07 0.43 2.39e-30 Schizophrenia; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg02951883 chr7:2050386 MAD1L1 -0.37 -8.3 -0.31 6.4e-16 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.09 0.49 1.94e-39 Motion sickness; BRCA trans rs11098499 0.954 rs2389803 chr4:120393511 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.34 -8.05 -0.3 4.09e-15 Corneal astigmatism; BRCA cis rs4363385 0.747 rs3753454 chr1:152973776 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.77 -0.33 1.57e-17 Inflammatory skin disease; BRCA cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.19 0.4 1.11e-26 Bipolar disorder; BRCA cis rs9287719 0.935 rs7600495 chr2:10739800 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs7959452 0.719 rs57954211 chr12:69748397 C/A cg14784868 chr12:69753453 YEATS4 0.66 17.61 0.57 7.06e-57 Blood protein levels; BRCA cis rs4891159 0.790 rs72975929 chr18:74144630 G/C cg24786174 chr18:74118243 ZNF516 -0.76 -18.49 -0.59 1.75e-61 Longevity; BRCA cis rs7520050 0.902 rs7514192 chr1:46248977 A/G cg24296786 chr1:45957014 TESK2 0.44 10.01 0.37 5.02e-22 Red blood cell count;Reticulocyte count; BRCA cis rs4363385 0.747 rs6671524 chr1:152974247 C/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.82 -0.36 2.6e-21 Inflammatory skin disease; BRCA cis rs4363385 0.818 rs57311099 chr1:153005597 A/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.46e-17 Inflammatory skin disease; BRCA cis rs56176327 0.532 rs9849038 chr3:49771990 A/G cg03060546 chr3:49711283 APEH 0.6 10.37 0.38 2.2e-23 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs13149404 chr4:99070236 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9880211 0.898 rs13434116 chr3:136353074 G/C cg21827317 chr3:136751795 NA -0.45 -7.97 -0.3 7.59e-15 Body mass index;Height; BRCA cis rs7607369 0.536 rs6436092 chr2:219669148 T/A cg02176678 chr2:219576539 TTLL4 -0.38 -10.16 -0.37 1.45e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg00071950 chr4:10020882 SLC2A9 -0.45 -10.56 -0.39 3.75e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12142240 0.698 rs6683192 chr1:46830257 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.72 0.36 6.42e-21 Menopause (age at onset); BRCA cis rs4665809 0.556 rs4665314 chr2:26415912 T/C cg08470875 chr2:26401718 FAM59B -0.77 -12.04 -0.43 3.14e-30 Gut microbiome composition (summer); BRCA trans rs2797160 1.000 rs2747723 chr6:126010790 C/T cg05039488 chr6:79577232 IRAK1BP1 0.35 8.01 0.3 5.47e-15 Endometrial cancer; BRCA cis rs13108904 0.870 rs4974541 chr4:1244037 A/G cg05665937 chr4:1216051 CTBP1 0.38 7.96 0.3 8.15e-15 Obesity-related traits; BRCA cis rs694739 0.628 rs508168 chr11:64135435 G/A cg26898376 chr11:64110657 CCDC88B 0.36 7.96 0.3 8.16e-15 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs12579753 0.879 rs1922552 chr12:82158093 G/T cg07988820 chr12:82153109 PPFIA2 -0.67 -11.23 -0.41 7.69e-27 Resting heart rate; BRCA cis rs4478858 0.684 rs4949374 chr1:31754511 G/C cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs16866061 0.515 rs3738951 chr2:225368321 A/G cg22455342 chr2:225449267 CUL3 0.34 9.13 0.34 9.24e-19 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs4363385 0.693 rs490553 chr1:153033277 A/G cg24667326 chr1:152973720 SPRR3 -0.31 -8.2 -0.31 1.28e-15 Inflammatory skin disease; BRCA cis rs9790314 0.779 rs1609688 chr3:160877096 T/G cg03342759 chr3:160939853 NMD3 -0.54 -10.64 -0.39 1.93e-24 Morning vs. evening chronotype; BRCA cis rs61931739 0.571 rs4001689 chr12:34243271 C/T cg06521331 chr12:34319734 NA -0.63 -11.8 -0.42 3.25e-29 Morning vs. evening chronotype; BRCA cis rs11931598 0.514 rs10937779 chr4:7039326 G/A cg19539972 chr4:7069911 GRPEL1 0.35 8.71 0.33 2.54e-17 Sum basophil neutrophil counts;Sum neutrophil eosinophil counts;Granulocyte count;Neutrophil count;Myeloid white cell count; BRCA cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg16414030 chr3:133502952 NA 0.47 11.17 0.4 1.44e-26 Iron status biomarkers; BRCA cis rs250677 0.687 rs250673 chr5:148445798 C/T cg12140854 chr5:148520817 ABLIM3 -0.42 -8.69 -0.33 3.04e-17 Breast cancer; BRCA cis rs1971762 0.523 rs7135101 chr12:54080605 G/A cg23533419 chr12:54090519 NA -0.34 -8.48 -0.32 1.57e-16 Height; BRCA cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.34 0.57 1.77e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs220324 0.647 rs9981668 chr21:43559780 G/T cg09727148 chr21:43560719 UMODL1 0.48 8.1 0.3 2.89e-15 Idiopathic osteonecrosis of the femoral head; BRCA cis rs12762955 0.677 rs11250267 chr10:1156487 A/G cg26597838 chr10:835615 NA 0.57 9.88 0.36 1.57e-21 Response to angiotensin II receptor blocker therapy; BRCA cis rs4588572 0.643 rs7701154 chr5:77716621 G/A cg11547950 chr5:77652471 NA -0.47 -8.44 -0.32 2.13e-16 Triglycerides; BRCA cis rs9486719 0.948 rs11152970 chr6:96909077 A/G cg06623918 chr6:96969491 KIAA0776 -0.72 -13.01 -0.46 1.72e-34 Migraine;Coronary artery disease; BRCA cis rs708547 0.624 rs1277284 chr4:57855361 T/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.43 11.73 0.42 6.3e-29 Response to bleomycin (chromatid breaks); BRCA trans rs66887589 0.934 rs41464847 chr4:120532401 A/G cg25214090 chr10:38739885 LOC399744 -0.34 -7.93 -0.3 9.68e-15 Diastolic blood pressure; BRCA cis rs7246657 0.943 rs8106839 chr19:37958475 C/G cg18154014 chr19:37997991 ZNF793 0.53 10.29 0.38 4.47e-23 Coronary artery calcification; BRCA cis rs6963495 0.818 rs73190163 chr7:105157294 G/T cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs4595586 0.545 rs3858554 chr12:39381460 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.38 0.35 1.12e-19 Morning vs. evening chronotype; BRCA cis rs4665809 0.590 rs7604564 chr2:26501953 C/A cg04944784 chr2:26401820 FAM59B 0.96 16.64 0.55 6.31e-52 Gut microbiome composition (summer); BRCA cis rs1371614 0.611 rs3845685 chr2:27130332 C/T cg12368169 chr2:27073192 DPYSL5 -0.29 -8.6 -0.32 6.29e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs1945213 0.694 rs10895985 chr11:55831595 T/C cg15704280 chr7:45808275 SEPT13 0.63 10.97 0.4 9.37e-26 Acute lymphoblastic leukemia (childhood); BRCA cis rs611744 0.647 rs615233 chr8:109254262 C/T cg21045802 chr8:109455806 TTC35 0.35 8.03 0.3 4.64e-15 Dupuytren's disease; BRCA trans rs7824557 0.737 rs2293855 chr8:11177410 G/A cg08975724 chr8:8085496 FLJ10661 0.43 8.06 0.3 3.68e-15 Retinal vascular caliber; BRCA cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9325144 0.647 rs1386018 chr12:39104360 C/T cg26384229 chr12:38710491 ALG10B -0.48 -11.23 -0.41 7.66e-27 Morning vs. evening chronotype; BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA trans rs9329221 0.736 rs12548025 chr8:10260921 A/T cg06636001 chr8:8085503 FLJ10661 0.53 10.05 0.37 3.77e-22 Neuroticism; BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs769267 0.965 rs2965191 chr19:19453521 T/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.5 -10.07 -0.37 3.07e-22 Tonsillectomy; BRCA cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg24692254 chr21:30365293 RNF160 0.63 14.49 0.5 2.49e-41 Selective IgA deficiency; BRCA cis rs3741151 1.000 rs3741151 chr11:73020846 G/T cg17517138 chr11:73019481 ARHGEF17 1.08 15.14 0.51 1.81e-44 GIP levels in response to oral glucose tolerance test (120 minutes); BRCA cis rs2011503 1.000 rs2916075 chr19:19530590 G/C cg11584989 chr19:19387371 SF4 0.63 13.42 0.47 2.3e-36 Bipolar disorder; BRCA cis rs911555 0.755 rs8018400 chr14:103901085 A/G cg12935359 chr14:103987150 CKB 0.64 15.06 0.51 4.38e-44 Intelligence (multi-trait analysis); BRCA cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg03161606 chr19:29218774 NA 0.46 8.11 0.31 2.56e-15 Methadone dose in opioid dependence; BRCA cis rs5771242 0.776 rs6010198 chr22:50610628 A/G cg16473166 chr22:50639996 SELO -0.65 -11.64 -0.42 1.53e-28 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); BRCA trans rs11165623 0.765 rs11807955 chr1:96891623 C/T cg10631902 chr5:14652156 NA -0.53 -17.12 -0.56 2.2e-54 Hip circumference;Waist circumference; BRCA cis rs6456156 1.000 rs7761159 chr6:167519907 T/A cg07741184 chr6:167504864 NA 0.27 8.22 0.31 1.18e-15 Primary biliary cholangitis; BRCA cis rs7737355 0.947 rs6883034 chr5:130920415 T/C cg06307176 chr5:131281290 NA 0.53 10.41 0.38 1.5e-23 Life satisfaction; BRCA cis rs10504229 0.724 rs16922734 chr8:58111192 C/T cg20607798 chr8:58055168 NA 0.48 8.24 0.31 9.65e-16 Developmental language disorder (linguistic errors); BRCA cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg11843238 chr5:131593191 PDLIM4 0.3 7.84 0.3 1.9e-14 Blood metabolite levels; BRCA trans rs61931739 0.534 rs11053005 chr12:34091626 A/C cg13010199 chr12:38710504 ALG10B 0.49 9.42 0.35 7.88e-20 Morning vs. evening chronotype; BRCA cis rs28374715 0.532 rs28584379 chr15:41670408 C/G cg18705301 chr15:41695430 NDUFAF1 -1.09 -24.87 -0.7 5.23e-96 Ulcerative colitis; BRCA cis rs12477438 0.677 rs12475034 chr2:99699464 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.64 -12.5 -0.44 2.99e-32 Chronic sinus infection; BRCA cis rs7647973 0.626 rs1078341 chr3:49685592 A/G cg07636037 chr3:49044803 WDR6 0.48 8.13 0.31 2.18e-15 Menarche (age at onset); BRCA cis rs7811142 1.000 rs73161759 chr7:100009994 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.14 0.34 7.92e-19 Platelet count; BRCA cis rs514406 0.505 rs447581 chr1:53177098 T/C cg24675658 chr1:53192096 ZYG11B -0.59 -13.53 -0.47 7.15e-37 Monocyte count; BRCA cis rs7945705 0.875 rs2568065 chr11:8889648 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.44 -0.5 4e-41 Hemoglobin concentration; BRCA cis rs7301826 0.651 rs1973834 chr12:131280157 C/T cg11011512 chr12:131303247 STX2 0.5 13.33 0.47 6.31e-36 Plasma plasminogen activator levels; BRCA cis rs597539 0.615 rs629426 chr11:68671104 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.51 0.59 1.48e-61 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1448094 0.512 rs7303330 chr12:86255123 G/A cg19622623 chr12:86230825 RASSF9 -0.35 -9.68 -0.36 9.34e-21 Major depressive disorder; BRCA cis rs881375 1.000 rs1953126 chr9:123640500 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.4 0.32 2.97e-16 Rheumatoid arthritis; BRCA cis rs270601 0.770 rs4361510 chr5:131599647 C/T cg11843238 chr5:131593191 PDLIM4 0.41 10.35 0.38 2.63e-23 Acylcarnitine levels; BRCA cis rs796364 0.806 rs11691873 chr2:200966337 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.65 -9.82 -0.36 2.77e-21 Schizophrenia; BRCA cis rs4906332 1.000 rs2065015 chr14:103904061 G/T cg26031613 chr14:104095156 KLC1 0.46 8.27 0.31 7.68e-16 Coronary artery disease; BRCA cis rs7246967 0.673 rs34671960 chr19:22948693 G/A cg23217946 chr19:22817039 ZNF492 0.5 9.07 0.34 1.46e-18 Bronchopulmonary dysplasia; BRCA cis rs2075371 1.000 rs1421486 chr7:133985196 T/C cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.95e-23 Mean platelet volume; BRCA trans rs17685 0.775 rs11761172 chr7:75761547 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11955398 0.585 rs10063166 chr5:60008844 C/T cg02684056 chr5:59996105 DEPDC1B -0.37 -9.04 -0.34 1.91e-18 Intelligence (multi-trait analysis); BRCA cis rs9381107 0.932 rs9349224 chr6:9471146 G/T cg14735645 chr6:9486422 NA -0.45 -8.01 -0.3 5.36e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs4319547 0.774 rs7307233 chr12:123124301 C/G cg23029597 chr12:123009494 RSRC2 -0.54 -11.14 -0.4 1.84e-26 Body mass index; BRCA cis rs208520 0.955 rs12204033 chr6:67001525 T/C cg07460842 chr6:66804631 NA 0.8 12.82 0.45 1.16e-33 Exhaled nitric oxide output; BRCA cis rs17376456 0.877 rs10062711 chr5:93348659 G/A cg25358565 chr5:93447407 FAM172A 1.21 18.7 0.59 1.45e-62 Diabetic retinopathy; BRCA trans rs9944715 1.000 rs9952654 chr18:43849568 T/G cg01718231 chr17:29326311 RNF135 -0.43 -8.63 -0.32 4.74e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs17711722 0.522 rs62469933 chr7:65265639 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.56 12.45 0.44 5.35e-32 Calcium levels; BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.94 19.22 0.61 2.53e-65 Alzheimer's disease; BRCA cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg18230493 chr5:56204884 C5orf35 0.74 14.85 0.51 4.63e-43 Initial pursuit acceleration; BRCA cis rs4563143 0.675 rs73029050 chr19:29276554 G/T cg12667521 chr19:29218732 NA 0.47 8.73 0.33 2.28e-17 Methadone dose in opioid dependence; BRCA trans rs12517041 0.935 rs10077662 chr5:23294524 C/G ch.8.1293020R chr8:59333349 UBXN2B -0.45 -8.13 -0.31 2.16e-15 Calcium levels; BRCA cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg03264133 chr6:25882463 NA -1.0 -26.7 -0.73 4.28e-106 Urate levels; BRCA cis rs9653442 0.835 rs7565967 chr2:100744683 G/T cg22139774 chr2:100720529 AFF3 -0.32 -8.83 -0.33 9.86e-18 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs9487051 0.837 rs1915834 chr6:109597624 C/A cg12927641 chr6:109611667 NA -0.4 -10.43 -0.38 1.3e-23 Reticulocyte fraction of red cells; BRCA cis rs614226 1.000 rs580016 chr12:120933977 T/C cg27489772 chr12:121021490 NA -0.48 -8.09 -0.3 3.04e-15 Type 1 diabetes nephropathy; BRCA cis rs7103648 0.966 rs896817 chr11:47394305 A/G cg03711944 chr11:47377212 SPI1 0.45 11.97 0.43 6.11e-30 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs875971 1.000 rs7781698 chr7:65896312 A/T cg18876405 chr7:65276391 NA 0.54 12.91 0.45 4.74e-34 Aortic root size; BRCA cis rs6964587 0.867 rs12704637 chr7:91874686 C/T cg17063962 chr7:91808500 NA 0.58 12.16 0.43 9.48e-31 Breast cancer; BRCA cis rs2204008 0.597 rs4002591 chr12:38133841 A/G cg13010199 chr12:38710504 ALG10B 0.44 8.88 0.33 6.92e-18 Bladder cancer; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.53 -0.38 5.05e-24 Lymphocyte counts; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg02353165 chr6:42928485 GNMT 0.77 19.06 0.6 1.75e-64 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs2727020 0.554 rs7111711 chr11:49557880 G/A cg15704280 chr7:45808275 SEPT13 -0.71 -14.55 -0.5 1.24e-41 Coronary artery disease; BRCA cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.46 -0.44 4.72e-32 Bipolar disorder; BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.31 -0.38 3.84e-23 Initial pursuit acceleration; BRCA cis rs6893300 0.524 rs62404348 chr5:179146026 G/A cg14593053 chr5:179126677 CANX 0.48 12.75 0.45 2.51e-33 Resting heart rate; BRCA cis rs9329289 0.603 rs2458698 chr10:2548452 C/T cg05625103 chr10:2543513 NA 0.42 9.06 0.34 1.57e-18 Age-related hearing impairment; BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg03609598 chr5:56110824 MAP3K1 -0.46 -7.85 -0.3 1.82e-14 Initial pursuit acceleration; BRCA cis rs6089584 0.925 rs35683654 chr20:60625401 G/T cg06108461 chr20:60628389 TAF4 0.93 17.75 0.57 1.29e-57 Body mass index; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.08 -0.43 2.14e-30 Alzheimer's disease; BRCA cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.31 -0.44 2.08e-31 Alzheimer's disease; BRCA cis rs13082711 0.640 rs66941564 chr3:27259702 C/A cg02860705 chr3:27208620 NA 0.57 11.63 0.42 1.67e-28 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA trans rs11098499 1.000 rs13116504 chr4:120209412 A/C cg25214090 chr10:38739885 LOC399744 0.48 10.67 0.39 1.41e-24 Corneal astigmatism; BRCA cis rs6540559 1.000 rs7522250 chr1:209962539 T/C cg23283495 chr1:209979779 IRF6 0.37 8.99 0.34 2.68e-18 Cleft lip with or without cleft palate; BRCA cis rs4642101 0.737 rs4299468 chr3:12825559 G/A cg24848339 chr3:12840334 CAND2 0.43 11.42 0.41 1.24e-27 QRS complex (12-leadsum); BRCA cis rs56104184 0.775 rs17272700 chr19:49391770 G/A cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.66 -0.36 1.02e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs6951245 1.000 rs76804143 chr7:1082021 C/T cg13565492 chr6:43139072 SRF -0.79 -11.17 -0.4 1.32e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.58 13.13 0.46 5.15e-35 Personality dimensions; BRCA cis rs11874712 0.966 rs8093880 chr18:43666786 C/T cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.21 0.31 1.24e-15 Migraine - clinic-based; BRCA cis rs4665809 1.000 rs4233709 chr2:26291493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.62 11.55 0.42 3.8e-28 Gut microbiome composition (summer); BRCA cis rs757081 0.671 rs214072 chr11:17305270 C/T cg15432903 chr11:17409602 KCNJ11 -0.49 -8.59 -0.32 6.68e-17 Systolic blood pressure; BRCA cis rs758324 0.947 rs1566427 chr5:131191672 G/A cg06307176 chr5:131281290 NA 0.54 10.46 0.38 9.95e-24 Alzheimer's disease in APOE e4- carriers; BRCA cis rs3845702 0.736 rs6433816 chr2:180809317 G/C cg01881094 chr2:180872142 CWC22 -1.02 -16.85 -0.55 5.38e-53 Schizophrenia; BRCA trans rs9929218 1.000 rs28660361 chr16:68800838 T/C cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.93 -0.48 1.03e-38 Colorectal cancer; BRCA cis rs6087990 0.669 rs2424929 chr20:31389518 A/G cg13636640 chr20:31349939 DNMT3B 0.62 17.13 0.56 2.03e-54 Ulcerative colitis; BRCA cis rs11252926 0.624 rs7085214 chr10:468133 A/G cg18196295 chr10:418757 DIP2C 0.5 11.29 0.41 4.33e-27 Psychosis in Alzheimer's disease; BRCA cis rs6831352 0.918 rs4699712 chr4:100060490 A/T cg12011299 chr4:100065546 ADH4 -0.51 -11.86 -0.42 1.83e-29 Alcohol dependence; BRCA cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.73 0.73 3.22e-106 Chronic sinus infection; BRCA cis rs2153535 0.580 rs4140586 chr6:8503192 A/G cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.86e-24 Motion sickness; BRCA cis rs7560272 0.538 rs11126414 chr2:73932044 G/A cg20560298 chr2:73613845 ALMS1 0.34 8.72 0.33 2.45e-17 Schizophrenia; BRCA cis rs7246657 0.722 rs8110865 chr19:38047387 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.13 0.34 8.69e-19 Coronary artery calcification; BRCA cis rs9487051 0.872 rs9398197 chr6:109609988 C/A cg12927641 chr6:109611667 NA -0.42 -10.89 -0.4 1.94e-25 Reticulocyte fraction of red cells; BRCA cis rs7267979 0.966 rs2257461 chr20:25265554 A/G cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13191362 1.000 rs35126854 chr6:163012443 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.71 0.33 2.58e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.16 0.34 7.24e-19 Tonsillectomy; BRCA cis rs17209837 0.607 rs4148811 chr7:87101486 T/G cg00919237 chr7:87102261 ABCB4 -0.53 -10.19 -0.37 1.04e-22 Gallbladder cancer; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg10862848 chr6:42927986 GNMT -0.36 -15.05 -0.51 5.11e-44 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs2204008 0.542 rs34770471 chr12:38009613 C/T cg06521331 chr12:34319734 NA -0.54 -9.65 -0.36 1.18e-20 Bladder cancer; BRCA cis rs10771431 0.935 rs1988852 chr12:9372862 G/A cg22349387 chr12:9600060 DDX12 -0.39 -8.92 -0.33 5.02e-18 Breast size; BRCA cis rs9329289 0.926 rs9329290 chr10:2542751 G/T cg15501526 chr10:2543763 NA 0.57 13.99 0.48 5.32e-39 Age-related hearing impairment; BRCA cis rs250677 1.000 rs190378 chr5:148434275 G/T cg18129178 chr5:148520854 ABLIM3 -0.57 -11.72 -0.42 7.24e-29 Breast cancer; BRCA cis rs765787 0.530 rs28756676 chr15:45540360 G/A cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs72781680 0.583 rs6731333 chr2:24113354 C/T cg08917208 chr2:24149416 ATAD2B 0.54 9.23 0.34 3.85e-19 Lymphocyte counts; BRCA cis rs870825 0.616 rs6552806 chr4:185638231 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.32 0.57 2.07e-55 Blood protein levels; BRCA cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg02187348 chr16:89574699 SPG7 0.52 12.34 0.44 1.54e-31 Multiple myeloma (IgH translocation); BRCA cis rs11030122 0.702 rs1349583 chr11:3972236 G/A cg18678763 chr11:4115507 RRM1 -0.36 -8.43 -0.32 2.28e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs35306767 0.953 rs7908138 chr10:962978 C/T cg25019033 chr10:957182 NA -0.43 -8.89 -0.33 6.11e-18 Eosinophil percentage of granulocytes; BRCA cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg00934597 chr7:893267 UNC84A -0.53 -11.87 -0.42 1.69e-29 Perceived unattractiveness to mosquitoes; BRCA trans rs2204008 0.818 rs7313608 chr12:38383428 C/A cg06521331 chr12:34319734 NA 0.45 9.01 0.34 2.42e-18 Bladder cancer; BRCA cis rs875971 0.540 rs736270 chr7:65428822 T/C cg11764359 chr7:65958608 NA 0.61 13.25 0.46 1.43e-35 Aortic root size; BRCA cis rs514406 0.793 rs12081018 chr1:53217542 C/A cg24675658 chr1:53192096 ZYG11B 0.56 12.72 0.45 3.21e-33 Monocyte count; BRCA cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs7267979 0.966 rs2257712 chr20:25264910 T/C cg08601574 chr20:25228251 PYGB 0.36 8.58 0.32 7.39e-17 Liver enzyme levels (alkaline phosphatase); BRCA trans rs10506458 0.915 rs17738485 chr12:63394932 T/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.24 -20.53 -0.63 2.46e-72 Hemostatic factors and hematological phenotypes; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.78 11.9 0.43 1.24e-29 Platelet count; BRCA cis rs11098499 0.535 rs10005542 chr4:120268302 T/C cg09307838 chr4:120376055 NA 0.59 12.89 0.45 5.65e-34 Corneal astigmatism; BRCA cis rs10751667 0.643 rs10794343 chr11:925493 C/T cg10932868 chr11:921992 NA 0.5 12.76 0.45 2.15e-33 Alzheimer's disease (late onset); BRCA cis rs7615952 0.599 rs67566088 chr3:125768973 C/A cg05084668 chr3:125655381 ALG1L -0.47 -8.16 -0.31 1.79e-15 Blood pressure (smoking interaction); BRCA cis rs17711722 0.701 rs781145 chr7:65440370 A/C cg11764359 chr7:65958608 NA 0.62 13.48 0.47 1.26e-36 Calcium levels; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg14789911 chr21:47582049 C21orf56 0.38 7.94 0.3 9.42e-15 Testicular germ cell tumor; BRCA cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg21545522 chr1:205238299 TMCC2 0.39 8.22 0.31 1.13e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs6089584 1.000 rs3787425 chr20:60559256 C/T cg06108461 chr20:60628389 TAF4 -0.79 -16.99 -0.56 1.11e-53 Body mass index; BRCA cis rs739401 0.611 rs7394974 chr11:3038868 C/T cg05729581 chr11:3078854 CARS -0.34 -8.45 -0.32 1.98e-16 Longevity; BRCA cis rs7666738 0.785 rs11944120 chr4:99079932 A/C cg17366294 chr4:99064904 C4orf37 0.42 8.29 0.31 6.76e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.962 rs6122344 chr20:61661738 C/T cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA trans rs12517041 1.000 rs2081952 chr5:23295605 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs10782582 0.593 rs115291524 chr1:76141811 A/G cg10523679 chr1:76189770 ACADM -0.45 -8.18 -0.31 1.49e-15 Daytime sleep phenotypes; BRCA cis rs7395581 0.877 rs7127907 chr11:47324472 A/C cg25783544 chr11:47291846 MADD 0.43 9.61 0.36 1.57e-20 HDL cholesterol; BRCA cis rs10193935 0.892 rs12622152 chr2:42482929 C/A cg27598129 chr2:42591480 NA -0.94 -14.7 -0.5 2.32e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 1.000 rs13106934 chr4:99028685 C/T cg17366294 chr4:99064904 C4orf37 0.52 11.13 0.4 1.97e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 8.35e-53 Axial length; BRCA cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg10057126 chr4:77819792 ANKRD56 -0.64 -14.99 -0.51 9.31e-44 Emphysema distribution in smoking; BRCA cis rs3741404 0.584 rs645461 chr11:63893694 C/T cg18225595 chr11:63971243 STIP1 -0.41 -10.17 -0.37 1.23e-22 Platelet count; BRCA cis rs3768617 0.510 rs10797837 chr1:183075121 C/G ch.1.3577855R chr1:183094577 LAMC1 0.68 18.02 0.58 4.98e-59 Fuchs's corneal dystrophy; BRCA cis rs9811920 0.535 rs792833 chr3:99475268 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.42 10.07 0.37 3.15e-22 Axial length; BRCA cis rs8180040 0.726 rs61729713 chr3:47027192 A/G cg16586182 chr3:47516702 SCAP 0.51 11.42 0.41 1.25e-27 Colorectal cancer; BRCA cis rs919433 0.726 rs11904247 chr2:198238424 T/G cg00792783 chr2:198669748 PLCL1 0.39 8.57 0.32 7.81e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs8062405 0.755 rs4787457 chr16:28555400 A/G cg16576597 chr16:28551801 NUPR1 0.35 9.68 0.36 9.01e-21 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg12016809 chr21:47604291 C21orf56 0.39 7.83 0.3 2.04e-14 Testicular germ cell tumor; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg14004847 chr7:1930337 MAD1L1 -0.4 -7.98 -0.3 7.04e-15 Bipolar disorder and schizophrenia; BRCA cis rs7918232 0.830 rs7911024 chr10:27433636 A/C cg14442939 chr10:27389572 ANKRD26 0.66 10.92 0.4 1.5e-25 Breast cancer; BRCA cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.52 -10.21 -0.37 8.95e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs12579753 1.000 rs11115030 chr12:82203021 A/T cg07988820 chr12:82153109 PPFIA2 -0.6 -9.76 -0.36 4.55e-21 Resting heart rate; BRCA cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12667521 chr19:29218732 NA 0.48 9.43 0.35 7.38e-20 Methadone dose in opioid dependence; BRCA cis rs7949030 0.620 rs2428551 chr11:62329758 T/A cg13298116 chr11:62369859 EML3;MTA2 0.55 13.07 0.46 9.18e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs3772130 0.962 rs11707504 chr3:121496734 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.67 0.39 1.38e-24 Cognitive performance; BRCA cis rs2625529 0.652 rs2957745 chr15:72288077 T/C cg16672083 chr15:72433130 SENP8 0.66 15.69 0.53 3.43e-47 Red blood cell count; BRCA cis rs208520 0.955 rs12202599 chr6:67001573 A/G cg07460842 chr6:66804631 NA 0.8 12.82 0.45 1.16e-33 Exhaled nitric oxide output; BRCA cis rs826838 0.616 rs7977357 chr12:38626008 C/G cg26384229 chr12:38710491 ALG10B -0.44 -10.14 -0.37 1.63e-22 Heart rate; BRCA cis rs61931739 0.534 rs11052984 chr12:34045904 T/C cg06521331 chr12:34319734 NA -0.63 -12.21 -0.43 5.64e-31 Morning vs. evening chronotype; BRCA cis rs858239 0.539 rs6461695 chr7:23197784 C/A cg23682824 chr7:23144976 KLHL7 0.36 9.44 0.35 6.71e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs870825 0.860 rs72689297 chr4:185600957 A/T cg04058563 chr4:185651563 MLF1IP 0.82 13.82 0.48 3.56e-38 Blood protein levels; BRCA cis rs6964587 1.000 rs2282971 chr7:91584356 A/G cg17063962 chr7:91808500 NA 0.55 13.11 0.46 6.08e-35 Breast cancer; BRCA cis rs4481887 0.927 rs4347240 chr1:248475403 C/G cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs2836950 0.501 rs2836980 chr21:40687618 G/T cg11644478 chr21:40555479 PSMG1 -0.52 -10.88 -0.4 1.99e-25 Menarche (age at onset); BRCA cis rs10206020 0.885 rs6720923 chr2:1574197 T/C cg26248373 chr2:1572462 NA -0.63 -14.96 -0.51 1.4e-43 IgG glycosylation; BRCA cis rs7149337 0.752 rs8021773 chr14:51691528 C/T cg23942311 chr14:51606299 NA 0.5 13.83 0.48 3.19e-38 Cancer; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.56 -0.32 8.26e-17 Total body bone mineral density; BRCA cis rs8180040 0.627 rs58956475 chr3:47224615 G/C cg27129171 chr3:47204927 SETD2 -0.72 -17.49 -0.57 2.94e-56 Colorectal cancer; BRCA cis rs2153535 0.580 rs6920779 chr6:8437624 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.0 0.34 2.56e-18 Motion sickness; BRCA cis rs7772486 0.590 rs1890170 chr6:146071839 G/C cg05347473 chr6:146136440 FBXO30 -0.61 -12.08 -0.43 2.04e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs4478858 0.735 rs12129941 chr1:31871958 C/G cg00250761 chr1:31883323 NA -0.34 -8.66 -0.32 3.91e-17 Alcohol dependence; BRCA cis rs9649465 0.967 rs11769381 chr7:123264804 C/T cg04330084 chr7:123175371 IQUB -0.33 -9.04 -0.34 1.85e-18 Migraine; BRCA cis rs2243480 1.000 rs6974723 chr7:65637939 C/T cg18252515 chr7:66147081 NA 1.06 15.97 0.53 1.49e-48 Diabetic kidney disease; BRCA cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg02574844 chr11:5959923 NA 0.37 7.98 0.3 6.71e-15 DNA methylation (variation); BRCA cis rs7309 0.935 rs11884495 chr2:162059969 A/T cg00599163 chr2:162100495 NA 0.27 8.9 0.33 5.59e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs16866061 1.000 rs7588380 chr2:225341304 A/T cg12698349 chr2:225449008 CUL3 -0.76 -20.79 -0.64 9.58e-74 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs17095355 1.000 rs11194922 chr10:111695656 G/T cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.05 -0.37 3.83e-22 Biliary atresia; BRCA cis rs10504229 0.683 rs10504224 chr8:58143735 A/G cg20607798 chr8:58055168 NA 0.58 9.32 0.35 1.88e-19 Developmental language disorder (linguistic errors); BRCA cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg20848291 chr7:100343083 ZAN 0.37 8.27 0.31 7.6e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg24642439 chr20:33292090 TP53INP2 0.7 16.07 0.54 4.49e-49 Coronary artery disease; BRCA cis rs1448094 0.512 rs7960130 chr12:86243191 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.31 -0.35 2.09e-19 Major depressive disorder; BRCA cis rs4919694 1.000 rs12252500 chr10:104794984 G/C cg04362960 chr10:104952993 NT5C2 0.94 14.51 0.5 1.96e-41 Arsenic metabolism; BRCA trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -14.94 -0.51 1.73e-43 Coronary artery disease; BRCA cis rs208520 0.690 rs10455194 chr6:66743356 A/G cg07460842 chr6:66804631 NA 0.99 19.93 0.62 4.01e-69 Exhaled nitric oxide output; BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg13047869 chr3:10149882 C3orf24 0.58 10.55 0.39 4.35e-24 Alzheimer's disease; BRCA cis rs9467773 0.529 rs7356988 chr6:26396727 G/T cg09904177 chr6:26538194 HMGN4 -0.36 -9.39 -0.35 1.01e-19 Intelligence (multi-trait analysis); BRCA cis rs11190604 0.767 rs11190533 chr10:102190792 T/C cg07080220 chr10:102295463 HIF1AN 0.44 9.8 0.36 3.18e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs933688 1.000 rs12651840 chr5:90729592 T/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.96 22.06 0.66 1.26e-80 Smoking behavior; BRCA cis rs6570726 0.846 rs6570698 chr6:145918635 C/G cg23711669 chr6:146136114 FBXO30 0.71 16.78 0.55 1.24e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs835154 0.900 rs835153 chr5:14877474 A/G cg18064842 chr5:14874549 NA -0.4 -10.39 -0.38 1.8e-23 Blood metabolite levels; BRCA cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -7.89 -0.3 1.36e-14 Extrinsic epigenetic age acceleration; BRCA cis rs4595586 0.545 rs12827197 chr12:39404362 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.58 0.35 2.03e-20 Morning vs. evening chronotype; BRCA cis rs2463822 1.000 rs72921501 chr11:62115622 A/T cg06239285 chr11:62104954 ASRGL1 -0.68 -9.75 -0.36 5.02e-21 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg01884057 chr2:25150051 NA 0.33 8.67 0.32 3.47e-17 Body mass index; BRCA cis rs35306767 0.761 rs11253538 chr10:1011166 C/T cg18964960 chr10:1102726 WDR37 0.59 8.0 0.3 5.81e-15 Eosinophil percentage of granulocytes; BRCA cis rs9287719 0.649 rs10186984 chr2:10734192 C/G cg00105475 chr2:10696890 NA -0.4 -8.92 -0.33 4.99e-18 Prostate cancer; BRCA trans rs2727020 0.718 rs1404366 chr11:49415899 T/A cg03929089 chr4:120376271 NA -0.74 -15.93 -0.53 2.31e-48 Coronary artery disease; BRCA cis rs6963495 0.818 rs73190189 chr7:105164452 G/A cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs2070488 0.965 rs2300668 chr3:38540541 A/G cg24069376 chr3:38537580 EXOG -0.4 -12.03 -0.43 3.48e-30 Electrocardiographic conduction measures; BRCA cis rs1691799 0.899 rs1168321 chr12:66744517 C/G cg16791601 chr12:66731901 HELB 0.69 19.56 0.61 4.03e-67 White blood cell count (basophil); BRCA trans rs10242455 0.702 rs6974831 chr7:99131605 A/G cg09045935 chr12:6379348 NA 0.85 8.24 0.31 9.68e-16 Blood metabolite levels; BRCA cis rs1800469 1.000 rs1549933 chr19:41871142 A/G cg08477640 chr19:41863820 B9D2 0.52 9.97 0.37 7.58e-22 Colorectal cancer; BRCA cis rs473651 0.935 rs515412 chr2:239345394 A/T cg14266287 chr2:239334506 ASB1 -0.35 -8.63 -0.32 4.86e-17 Multiple system atrophy; BRCA cis rs72627123 0.867 rs74395411 chr14:74478584 T/C cg12022184 chr14:74485813 ENTPD5;C14orf45 0.66 7.93 0.3 9.93e-15 Morning vs. evening chronotype; BRCA cis rs9660180 0.783 rs1107910 chr1:1692321 C/T cg22376730 chr1:1715039 NA -0.36 -9.43 -0.35 7.59e-20 Body mass index; BRCA cis rs1801251 0.778 rs709934 chr2:233733352 A/G cg08000102 chr2:233561755 GIGYF2 -0.43 -9.31 -0.35 1.98e-19 Coronary artery disease; BRCA cis rs6964587 1.000 rs4265 chr7:91719608 A/G cg01689657 chr7:91764605 CYP51A1 -0.22 -8.02 -0.3 5.04e-15 Breast cancer; BRCA cis rs9790314 0.846 rs6768818 chr3:160951648 A/G cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.17e-59 Morning vs. evening chronotype; BRCA cis rs3761847 0.622 rs4837807 chr9:123792005 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.38 7.9 0.3 1.21e-14 Rheumatoid arthritis; BRCA cis rs28374715 0.635 rs8023530 chr15:41647775 T/C cg18705301 chr15:41695430 NDUFAF1 -0.83 -19.57 -0.61 3.66e-67 Ulcerative colitis; BRCA trans rs5756813 0.661 rs5995500 chr22:38204640 A/G cg19894588 chr14:64061835 NA -0.55 -11.58 -0.42 2.82e-28 Optic cup area;Vertical cup-disc ratio; BRCA cis rs7618915 0.547 rs2590846 chr3:52692359 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.96 0.37 8.29e-22 Bipolar disorder; BRCA trans rs7647973 0.626 rs4855845 chr3:49687043 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -7.93 -0.3 9.63e-15 Menarche (age at onset); BRCA cis rs765787 0.530 rs55771002 chr15:45541566 T/C cg24006582 chr15:45444508 DUOX1 -0.56 -11.57 -0.42 2.96e-28 Uric acid levels; BRCA cis rs2354432 0.607 rs4314933 chr1:146821386 T/C cg25205988 chr1:146714368 CHD1L 0.88 12.64 0.45 7.25e-33 Mitochondrial DNA levels; BRCA cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg12011299 chr4:100065546 ADH4 0.48 10.8 0.39 4.48e-25 Smoking initiation; BRCA cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg08477640 chr19:41863820 B9D2 -0.54 -10.49 -0.38 7.56e-24 Colorectal cancer; BRCA cis rs10504229 1.000 rs66477954 chr8:58187810 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs953387 1.000 rs4954566 chr2:136901513 A/G cg05194412 chr2:137003533 NA 0.37 8.56 0.32 8.65e-17 Arthritis (juvenile idiopathic); BRCA cis rs477895 0.653 rs3824854 chr11:63885305 C/T cg23719950 chr11:63933701 MACROD1 -0.56 -8.93 -0.33 4.54e-18 Mean platelet volume; BRCA cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs4845875 0.626 rs7538516 chr1:11836682 C/T cg24844545 chr1:11908347 NPPA 0.32 8.09 0.3 2.93e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs1865760 1.000 rs9358893 chr6:25921761 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 11.44 0.41 1.11e-27 Height; BRCA cis rs999943 0.774 rs10947421 chr6:33611278 G/T cg14003231 chr6:33640908 ITPR3 0.62 14.08 0.49 2.06e-39 Obesity (extreme); BRCA cis rs12541635 0.966 rs7839195 chr8:107020193 G/A cg10147462 chr8:107024639 NA 0.35 9.54 0.35 3.04e-20 Age of smoking initiation; BRCA cis rs6088590 1.000 rs2236270 chr20:33523155 G/T cg24642439 chr20:33292090 TP53INP2 0.71 15.86 0.53 5.49e-48 Coronary artery disease; BRCA cis rs12142240 0.698 rs1057533 chr1:46815836 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA trans rs1005277 0.579 rs2023351 chr10:38378814 A/G cg23533926 chr12:111358616 MYL2 -0.41 -8.49 -0.32 1.4e-16 Extrinsic epigenetic age acceleration; BRCA cis rs889312 0.500 rs11960484 chr5:56109154 C/T cg24531977 chr5:56204891 C5orf35 0.4 7.99 0.3 6.16e-15 Breast cancer;Breast cancer (early onset); BRCA cis rs2425143 1.000 rs8124505 chr20:34307247 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -8.88 -0.33 6.53e-18 Blood protein levels; BRCA cis rs7945718 0.967 rs12291695 chr11:12795662 A/G cg25843174 chr11:12811716 TEAD1 -0.24 -8.98 -0.33 2.94e-18 Educational attainment (years of education); BRCA cis rs2576037 0.583 rs2571028 chr18:44561100 C/G cg19077165 chr18:44547161 KATNAL2 0.64 14.8 0.51 7.87e-43 Personality dimensions; BRCA cis rs10870270 0.913 rs4550 chr10:133781798 C/T cg17892150 chr10:133769511 PPP2R2D -0.7 -14.84 -0.51 5.18e-43 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2479724 0.875 rs2253961 chr6:41827011 A/G cg17623882 chr6:41773611 USP49 -0.34 -9.07 -0.34 1.43e-18 Menarche (age at onset); BRCA cis rs11098499 0.866 rs13125526 chr4:120288019 G/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA trans rs7824557 0.836 rs1435278 chr8:11123029 G/T cg15556689 chr8:8085844 FLJ10661 -0.41 -9.79 -0.36 3.58e-21 Retinal vascular caliber; BRCA cis rs1552244 0.882 rs113268531 chr3:10167069 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -12.08 -0.43 2.14e-30 Alzheimer's disease; BRCA trans rs9944715 0.911 rs7230154 chr18:43835793 C/T cg01718231 chr17:29326311 RNF135 -0.47 -9.34 -0.35 1.61e-19 Red cell distribution width;Mean corpuscular volume; BRCA cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg11530693 chr1:120165357 ZNF697 0.62 14.94 0.51 1.68e-43 Systemic lupus erythematosus; BRCA cis rs3771570 0.901 rs56129392 chr2:242242439 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.63 0.36 1.43e-20 Prostate cancer; BRCA trans rs6076960 0.652 rs3843045 chr20:6264593 C/T cg21095983 chr6:86352623 SYNCRIP -0.35 -8.1 -0.31 2.82e-15 Smooth-surface caries; BRCA cis rs483180 0.531 rs541503 chr1:120208297 A/G cg19096424 chr1:120255104 PHGDH -0.43 -9.56 -0.35 2.56e-20 Macular telangiectasia type 2; BRCA trans rs7824557 0.628 rs7820301 chr8:11228672 G/A cg06636001 chr8:8085503 FLJ10661 0.43 8.55 0.32 8.86e-17 Retinal vascular caliber; BRCA cis rs7819412 0.740 rs11250119 chr8:11037034 C/T cg21775007 chr8:11205619 TDH -0.44 -8.67 -0.32 3.47e-17 Triglycerides; BRCA cis rs6882046 0.513 rs34316 chr5:88015545 A/C cg22951263 chr5:87985283 NA -0.39 -10.61 -0.39 2.47e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg22875332 chr1:76189707 ACADM -0.65 -12.34 -0.44 1.59e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9914988 0.887 rs11652710 chr17:27145075 C/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.81 -0.33 1.13e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs6484504 0.600 rs12796587 chr11:31266443 T/C cg14844989 chr11:31128820 NA -0.44 -9.54 -0.35 3.05e-20 Red blood cell count; BRCA cis rs12893668 0.603 rs12896171 chr14:104135966 A/G cg08213375 chr14:104286397 PPP1R13B 0.41 8.81 0.33 1.16e-17 Reticulocyte count; BRCA cis rs7520050 0.872 rs2486445 chr1:46605369 C/T cg24296786 chr1:45957014 TESK2 0.4 8.91 0.33 5.39e-18 Red blood cell count;Reticulocyte count; BRCA cis rs68170813 0.523 rs12154285 chr7:106993573 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.76 -0.33 1.82e-17 Coronary artery disease; BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg12311346 chr5:56204834 C5orf35 -0.79 -14.91 -0.51 2.27e-43 Initial pursuit acceleration; BRCA cis rs7617773 0.780 rs11706277 chr3:48360433 A/G cg11946769 chr3:48343235 NME6 0.68 13.65 0.48 2.13e-37 Coronary artery disease; BRCA cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.83 0.42 2.54e-29 Height; BRCA trans rs61931739 0.500 rs11053269 chr12:34545307 A/G cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA cis rs9393777 0.623 rs9358947 chr6:26479000 G/A cg12826209 chr6:26865740 GUSBL1 0.56 9.23 0.34 3.92e-19 Intelligence (multi-trait analysis); BRCA cis rs208520 0.690 rs207112 chr6:66792092 C/T cg07460842 chr6:66804631 NA -1.02 -20.41 -0.63 1.11e-71 Exhaled nitric oxide output; BRCA trans rs11098499 0.863 rs1155576 chr4:120450159 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.85 0.3 1.7e-14 Corneal astigmatism; BRCA cis rs7766436 0.767 rs6456498 chr6:22603610 A/G cg13666174 chr6:22585274 NA 0.36 9.2 0.34 5.08e-19 Coronary artery disease; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg09177884 chr7:1199841 ZFAND2A -0.36 -7.97 -0.3 7.08e-15 Longevity;Endometriosis; BRCA cis rs9486715 0.867 rs1127175 chr6:96999725 C/T cg06623918 chr6:96969491 KIAA0776 -0.85 -22.22 -0.66 1.65e-81 Headache; BRCA cis rs3743102 0.591 rs17841171 chr15:83358388 C/T cg00614314 chr15:82944287 LOC80154 0.58 8.31 0.31 5.66e-16 Colorectal adenoma (advanced); BRCA cis rs9787249 0.957 rs41267029 chr1:40214367 A/G cg24920358 chr1:40204285 PPIE 0.33 7.81 0.3 2.3e-14 Blood protein levels; BRCA cis rs873946 0.504 rs12254034 chr10:134571007 T/C cg27286337 chr10:134555280 INPP5A 0.63 11.25 0.41 6.61e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs17685 0.753 rs10085567 chr7:75734206 A/C cg19862616 chr7:65841803 NCRNA00174 0.83 26.67 0.73 6.33e-106 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11098499 0.644 rs3986377 chr4:120260270 G/A cg09307838 chr4:120376055 NA 0.59 12.83 0.45 1.12e-33 Corneal astigmatism; BRCA cis rs3862030 0.720 rs7342070 chr10:104223628 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.43 -12.52 -0.44 2.68e-32 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs7100689 0.646 rs7092237 chr10:82165640 A/G cg01528321 chr10:82214614 TSPAN14 0.82 18.35 0.59 1.05e-60 Post bronchodilator FEV1; BRCA cis rs35110281 0.776 rs2838338 chr21:45075582 T/C cg04455712 chr21:45112962 RRP1B 0.39 9.99 0.37 6.34e-22 Mean corpuscular volume; BRCA cis rs9329221 0.651 rs2975648 chr8:10135976 C/T cg27411982 chr8:10470053 RP1L1 -0.32 -8.02 -0.3 5.16e-15 Neuroticism; BRCA cis rs13191362 1.000 rs34725898 chr6:163127302 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.66 10.48 0.38 8.08e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9814567 1.000 rs12637751 chr3:134266124 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.863 rs11731756 chr4:120478696 T/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.26 0.31 8.38e-16 Corneal astigmatism; BRCA cis rs1707322 1.000 rs7527079 chr1:46413450 C/G cg06784218 chr1:46089804 CCDC17 0.46 10.93 0.4 1.34e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7824557 0.872 rs2572417 chr8:11111462 A/T cg06636001 chr8:8085503 FLJ10661 -0.52 -11.16 -0.4 1.55e-26 Retinal vascular caliber; BRCA cis rs4891159 0.660 rs4891160 chr18:74102135 C/T cg24786174 chr18:74118243 ZNF516 0.65 17.04 0.56 5.63e-54 Longevity; BRCA cis rs56235845 0.694 rs11949401 chr5:176765989 A/G cg06060754 chr5:176797920 RGS14 0.57 10.96 0.4 9.78e-26 Hemoglobin concentration;Hematocrit; BRCA cis rs6089829 0.962 rs6089825 chr20:61668447 C/T cg08564027 chr20:61660810 NA 0.84 22.45 0.66 9.41e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs28830936 1.000 rs2412622 chr15:41960311 A/G cg17847044 chr15:42102381 MAPKBP1 -0.32 -9.21 -0.34 4.55e-19 Diastolic blood pressure; BRCA cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg06238570 chr21:40685208 BRWD1 -0.4 -8.19 -0.31 1.41e-15 Menarche (age at onset); BRCA cis rs11608355 0.515 rs4766609 chr12:109973297 A/G cg05360138 chr12:110035743 NA 0.73 13.34 0.47 5.74e-36 Neuroticism; BRCA cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg25457927 chr22:38595422 NA -0.33 -12.16 -0.43 9.55e-31 Cutaneous nevi; BRCA cis rs4423214 0.840 rs1123007 chr11:71185357 G/A cg05163923 chr11:71159392 DHCR7 -0.57 -11.36 -0.41 2.3e-27 Vitamin D levels; BRCA cis rs8177253 1.000 rs8177272 chr3:133482870 C/T cg11941060 chr3:133502564 NA -0.52 -12.3 -0.44 2.34e-31 Iron status biomarkers; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.99 -0.3 6.09e-15 Total body bone mineral density; BRCA cis rs7666738 0.830 rs2019163 chr4:99022747 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.71 0.57 2.09e-57 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.84 -12.74 -0.45 2.85e-33 Platelet count; BRCA cis rs1129187 0.934 rs9471974 chr6:42918984 T/A cg24101359 chr6:42928495 GNMT 0.62 14.93 0.51 1.93e-43 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs8073060 0.586 rs2523114 chr17:34023762 G/A cg19694781 chr19:47549865 TMEM160 -1.07 -21.74 -0.65 6.98e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg26384229 chr12:38710491 ALG10B 0.58 13.14 0.46 4.59e-35 Morning vs. evening chronotype; BRCA cis rs1371614 0.566 rs10184824 chr2:27177952 C/A cg00617064 chr2:27272375 NA 0.3 7.83 0.3 2.09e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2072499 1.000 rs2241108 chr1:156181007 C/G cg24450063 chr1:156163899 SLC25A44 1.08 34.46 0.81 7.64e-148 Testicular germ cell tumor; BRCA cis rs3125734 0.633 rs4979773 chr10:63967731 G/C cg19640130 chr10:64028056 RTKN2 -0.31 -8.86 -0.33 8.19e-18 Rheumatoid arthritis; BRCA cis rs832540 0.931 rs832529 chr5:56229288 C/T cg24531977 chr5:56204891 C5orf35 -0.41 -8.31 -0.31 5.65e-16 Coronary artery disease; BRCA cis rs4665809 0.590 rs2384361 chr2:26452209 T/C cg08067268 chr2:26466485 HADHB;HADHA -0.57 -9.97 -0.37 7.31e-22 Gut microbiome composition (summer); BRCA trans rs1493916 0.777 rs1941685 chr18:31304318 G/T cg15819921 chr19:927150 ARID3A -0.43 -8.39 -0.32 3.06e-16 Life satisfaction; BRCA cis rs61931739 0.517 rs10844802 chr12:34231001 C/A cg06521331 chr12:34319734 NA -0.65 -11.92 -0.43 1.01e-29 Morning vs. evening chronotype; BRCA cis rs6684514 1.000 rs12027741 chr1:156248148 T/G cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9814567 0.896 rs6790338 chr3:134208167 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.72 -0.62 5.65e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6964587 1.000 rs10270598 chr7:91700827 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs10276381 1.000 rs10276381 chr7:28190121 A/G cg23620719 chr7:28220237 JAZF1 -0.56 -9.63 -0.36 1.42e-20 Crohn's disease; BRCA cis rs7631605 0.905 rs11714667 chr3:37222360 G/A cg15934958 chr3:37212084 LRRFIP2 0.4 9.28 0.34 2.58e-19 Cerebrospinal P-tau181p levels; BRCA cis rs708547 0.830 rs1713983 chr4:57883084 A/G cg16868167 chr4:57843880 C4orf14;POLR2B 0.52 13.29 0.47 9.34e-36 Response to bleomycin (chromatid breaks); BRCA cis rs17401966 0.931 rs1002076 chr1:10438892 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.18 -0.31 1.5e-15 Hepatocellular carcinoma; BRCA cis rs9649213 0.593 rs1859482 chr7:97983774 C/T cg21770322 chr7:97807741 LMTK2 0.44 11.54 0.42 3.92e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs600806 0.815 rs4970754 chr1:109969721 A/G cg20591472 chr1:110008990 SYPL2 0.33 8.34 0.31 4.7e-16 Intelligence (multi-trait analysis); BRCA cis rs9660992 0.686 rs1668870 chr1:205239031 C/G cg00857998 chr1:205179979 DSTYK 0.44 8.4 0.32 2.98e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs6952808 0.723 rs4721264 chr7:2012997 G/A cg05863683 chr7:1912471 MAD1L1 0.39 8.48 0.32 1.62e-16 Bipolar disorder and schizophrenia; BRCA cis rs9388451 0.536 rs34725880 chr6:126155237 A/G cg05901451 chr6:126070800 HEY2 -0.55 -13.48 -0.47 1.3e-36 Brugada syndrome; BRCA cis rs9814567 1.000 rs12490835 chr3:134223730 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.8 -0.62 2.12e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3772130 1.000 rs3732408 chr3:121421179 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.61 0.36 1.57e-20 Cognitive performance; BRCA cis rs7177699 0.557 rs9806363 chr15:79110302 A/G cg00540400 chr15:79124168 NA -0.28 -7.84 -0.3 1.95e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs9291683 0.527 rs3822241 chr4:10094931 G/A cg11266682 chr4:10021025 SLC2A9 -0.44 -11.39 -0.41 1.75e-27 Bone mineral density; BRCA cis rs7246657 0.653 rs28701616 chr19:37681098 G/A cg18154014 chr19:37997991 ZNF793 0.53 8.73 0.33 2.18e-17 Coronary artery calcification; BRCA cis rs10876993 0.890 rs1678539 chr12:58060359 A/G cg00677455 chr12:58241039 CTDSP2 -0.35 -7.92 -0.3 1.07e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs936229 0.861 rs7176022 chr15:75107880 G/T cg14664628 chr15:75095509 CSK 0.92 29.06 0.75 5.33e-119 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs2235642 0.685 rs2667681 chr16:1653206 C/T cg26528668 chr16:1614120 IFT140 0.36 7.88 0.3 1.39e-14 Coronary artery disease; BRCA cis rs780096 0.526 rs780112 chr2:27665361 C/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6.26e-18 Total body bone mineral density; BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs7264396 0.790 rs6121015 chr20:34243017 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.76 -16.03 -0.54 7.53e-49 Total cholesterol levels; BRCA cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.569 rs6556834 chr5:93123067 C/T cg25358565 chr5:93447407 FAM172A -0.67 -11.57 -0.42 2.94e-28 Diabetic retinopathy; BRCA cis rs654351 0.572 rs813274 chr6:10387731 C/T cg17959970 chr6:10383164 NA -0.41 -8.71 -0.33 2.61e-17 Squamous cell lung carcinoma; BRCA cis rs7178424 0.743 rs8032681 chr15:62162243 T/C cg00456672 chr15:62358751 C2CD4A -0.37 -8.9 -0.33 5.79e-18 Height; BRCA cis rs2836950 0.520 rs8133927 chr21:40689961 G/T cg06238570 chr21:40685208 BRWD1 -0.4 -8.18 -0.31 1.55e-15 Menarche (age at onset); BRCA cis rs9467711 0.591 rs72834617 chr6:25999175 G/A cg21479132 chr6:26055353 NA 0.57 7.97 0.3 7.48e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs10504229 0.683 rs7835498 chr8:58129780 A/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs1008375 0.966 rs2315553 chr4:17627332 T/C cg16339924 chr4:17578868 LAP3 0.64 16.11 0.54 2.94e-49 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7666738 0.830 rs4699593 chr4:98980628 A/G cg05340658 chr4:99064831 C4orf37 0.68 17.05 0.56 5.48e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg14789911 chr21:47582049 C21orf56 -0.38 -7.96 -0.3 7.68e-15 Testicular germ cell tumor; BRCA cis rs34172651 0.876 rs7186893 chr16:24806420 G/T cg04756594 chr16:24857601 SLC5A11 0.34 8.31 0.31 5.53e-16 Intelligence (multi-trait analysis); BRCA cis rs6089829 0.926 rs6011552 chr20:61667894 T/C cg03213289 chr20:61660250 NA 0.62 15.65 0.53 5.63e-47 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg26314531 chr2:26401878 FAM59B 0.96 16.47 0.55 4.54e-51 Gut microbiome composition (summer); BRCA trans rs61931739 0.513 rs10743833 chr12:33897481 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.47e-20 Morning vs. evening chronotype; BRCA cis rs12142240 0.698 rs41293273 chr1:46806393 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.22 0.31 1.12e-15 Menopause (age at onset); BRCA cis rs30380 0.632 rs30186 chr5:96124447 G/C cg16492584 chr5:96139282 ERAP1 -0.45 -10.81 -0.39 4.13e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs11758351 0.660 rs11753131 chr6:26219384 G/A cg01420254 chr6:26195488 NA 0.57 8.81 0.33 1.15e-17 Gout;Renal underexcretion gout; BRCA cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg18404041 chr3:52824283 ITIH1 -0.39 -11.99 -0.43 5.2e-30 Bipolar disorder; BRCA cis rs13191362 1.000 rs67025553 chr6:163011552 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.05 0.34 1.7e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1448094 0.717 rs60713909 chr12:86294469 C/G cg19622623 chr12:86230825 RASSF9 -0.28 -8.0 -0.3 5.93e-15 Major depressive disorder; BRCA trans rs11098499 0.820 rs6829903 chr4:120506884 C/T cg25214090 chr10:38739885 LOC399744 0.52 11.42 0.41 1.26e-27 Corneal astigmatism; BRCA cis rs11051970 0.636 rs325421 chr12:32571595 C/T cg24626660 chr12:32551988 NA 0.32 9.14 0.34 8.08e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9462027 0.628 rs9469859 chr6:34722902 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.27 -8.25 -0.31 9.32e-16 Systemic lupus erythematosus; BRCA cis rs2882667 0.964 rs12055237 chr5:138307306 A/G cg04439458 chr5:138467593 SIL1 -0.34 -9.19 -0.34 5.57e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7647973 1.000 rs6805609 chr3:49471522 C/G cg07636037 chr3:49044803 WDR6 -0.75 -15.35 -0.52 1.62e-45 Menarche (age at onset); BRCA cis rs7666738 0.830 rs10440379 chr4:98902822 G/T cg17366294 chr4:99064904 C4orf37 0.42 9.7 0.36 7.56e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs757081 0.667 rs615424 chr11:17210481 G/A cg15432903 chr11:17409602 KCNJ11 -0.46 -8.68 -0.32 3.16e-17 Systolic blood pressure; BRCA cis rs6860806 0.531 rs2631359 chr5:131707892 C/T cg24060327 chr5:131705240 SLC22A5 0.6 11.01 0.4 6.21e-26 Breast cancer; BRCA cis rs6582630 0.519 rs8189561 chr12:38296178 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.45 0.38 1.07e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs13118159 0.573 rs4974618 chr4:1373663 C/T cg02475777 chr4:1388615 CRIPAK 0.56 11.2 0.41 1.01e-26 Longevity; BRCA cis rs1862618 0.525 rs832403 chr5:56265992 G/T cg24549020 chr5:56110836 MAP3K1 -0.47 -8.21 -0.31 1.25e-15 Initial pursuit acceleration; BRCA cis rs7267979 1.000 rs2257982 chr20:25269630 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs28595532 0.623 rs34082100 chr4:119220563 C/T cg21605333 chr4:119757512 SEC24D 0.81 8.49 0.32 1.49e-16 Cannabis dependence symptom count; BRCA cis rs1878931 0.582 rs27227 chr16:3429778 G/A cg02880119 chr16:3481970 NA 0.42 7.92 0.3 1.06e-14 Body mass index (adult); BRCA cis rs4268898 0.636 rs72787383 chr2:24583861 G/A cg08917208 chr2:24149416 ATAD2B 0.51 8.12 0.31 2.38e-15 Asthma; BRCA cis rs2289583 0.573 rs8025880 chr15:75394881 G/C cg14664628 chr15:75095509 CSK 0.39 9.11 0.34 1.08e-18 Systemic lupus erythematosus; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.58 8.8 0.33 1.28e-17 Platelet count; BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.54 -0.52 1.93e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs873946 0.648 rs12766050 chr10:134549108 G/A cg27286337 chr10:134555280 INPP5A 0.78 12.77 0.45 2.09e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7772486 0.754 rs9399567 chr6:146147295 C/T cg13319975 chr6:146136371 FBXO30 -0.43 -9.87 -0.36 1.71e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg05552183 chr6:42928497 GNMT 0.7 15.79 0.53 1.2e-47 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg23978390 chr7:1156363 C7orf50 0.41 9.25 0.34 3.22e-19 Longevity;Endometriosis; BRCA cis rs11585357 0.895 rs2977305 chr1:17613737 A/T cg08277548 chr1:17600880 PADI3 0.62 11.01 0.4 6e-26 Hair shape; BRCA cis rs11874712 0.899 rs11664764 chr18:43675364 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.05 0.3 4.16e-15 Migraine - clinic-based; BRCA cis rs28735056 1.000 rs28865701 chr18:77620911 A/G cg20368463 chr18:77673604 PQLC1 -0.33 -7.98 -0.3 6.68e-15 Schizophrenia; BRCA cis rs4975709 0.589 rs4975744 chr5:1860049 A/G cg01114163 chr5:1856713 NA -0.36 -8.01 -0.3 5.27e-15 Cardiovascular disease risk factors; BRCA cis rs6815814 0.950 rs73236632 chr4:38836071 G/A cg02016764 chr4:38805732 TLR1 -0.52 -8.1 -0.31 2.7e-15 Breast cancer; BRCA cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8062405 0.792 rs12446550 chr16:28543381 G/A cg16576597 chr16:28551801 NUPR1 0.3 8.52 0.32 1.14e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7617773 0.784 rs9850672 chr3:48301172 C/A cg11946769 chr3:48343235 NME6 0.62 13.61 0.47 3.25e-37 Coronary artery disease; BRCA trans rs4714291 0.928 rs1923461 chr6:39984670 A/T cg02267698 chr19:7991119 CTXN1 0.4 7.9 0.3 1.18e-14 Strep throat; BRCA cis rs921968 0.541 rs581013 chr2:219432040 G/T cg10223061 chr2:219282414 VIL1 -0.27 -8.03 -0.3 4.76e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs72928364 1.000 rs34272575 chr3:100615407 C/G cg10123952 chr3:100791384 NA 0.53 7.89 0.3 1.33e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg22920501 chr2:26401640 FAM59B -0.96 -16.92 -0.56 2.42e-53 Gut microbiome composition (summer); BRCA cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.04 0.37 3.97e-22 Morning vs. evening chronotype; BRCA cis rs7640424 0.754 rs182736 chr3:107838891 C/A cg09227934 chr3:107805635 CD47 0.4 8.45 0.32 1.92e-16 Body mass index; BRCA cis rs7178424 0.811 rs12593844 chr15:62247067 T/C cg00456672 chr15:62358751 C2CD4A 0.34 8.32 0.31 5.46e-16 Height; BRCA cis rs1401999 0.690 rs3805112 chr3:183645662 C/T cg20387954 chr3:183756860 HTR3D 0.37 8.61 0.32 5.73e-17 Anterior chamber depth; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00908189 chr16:619842 PIGQ 0.71 17.86 0.58 3.47e-58 Height; BRCA cis rs4409675 0.576 rs7533918 chr1:28230667 G/A cg23691781 chr1:28212827 C1orf38 0.32 10.85 0.39 2.62e-25 Corneal astigmatism; BRCA cis rs992157 0.710 rs10169718 chr2:219103580 C/T cg00012203 chr2:219082015 ARPC2 -0.72 -16.17 -0.54 1.45e-49 Colorectal cancer; BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 13.76 0.48 6.16e-38 Platelet count; BRCA trans rs61931739 0.500 rs11053243 chr12:34514155 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.53 0.47 7.42e-37 Morning vs. evening chronotype; BRCA cis rs1020064 0.895 rs2250659 chr2:105889684 A/G cg02079111 chr2:105885981 TGFBRAP1 0.65 12.05 0.43 2.95e-30 AIDS; BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg08132940 chr7:1081526 C7orf50 -0.46 -8.35 -0.31 4.09e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs8030485 0.728 rs13379886 chr15:79394894 A/G cg17916960 chr15:79447300 NA -0.35 -8.22 -0.31 1.11e-15 Left ventricle wall thickness; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg08888203 chr3:10149979 C3orf24 0.69 14.79 0.51 8.7e-43 Alzheimer's disease; BRCA trans rs11098499 1.000 rs10029750 chr4:120172543 A/G cg25214090 chr10:38739885 LOC399744 0.48 10.6 0.39 2.75e-24 Corneal astigmatism; BRCA trans rs1994135 0.549 rs2218650 chr12:33734783 A/G cg26384229 chr12:38710491 ALG10B 0.44 9.56 0.35 2.44e-20 Resting heart rate; BRCA cis rs6547741 0.844 rs7382 chr2:27873415 G/A cg27432699 chr2:27873401 GPN1 -0.54 -11.32 -0.41 3.2e-27 Oral cavity cancer; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.6 -0.45 1.15e-32 Alzheimer's disease; BRCA cis rs6089829 0.692 rs6122349 chr20:61664096 T/C cg03213289 chr20:61660250 NA 0.57 12.77 0.45 2.09e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs3806843 0.735 rs778595 chr5:140036681 G/A cg11822812 chr5:140052017 DND1 -0.29 -7.88 -0.3 1.37e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs9354352 0.935 rs9345749 chr6:66699892 G/T cg07460842 chr6:66804631 NA -0.57 -11.26 -0.41 6.15e-27 Initial pursuit acceleration in psychotic disorders; BRCA trans rs6089829 0.962 rs9680064 chr20:61666168 G/A cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs332507 0.830 rs12639478 chr3:124404958 T/A cg05980111 chr3:124395277 KALRN 0.37 8.65 0.32 4.31e-17 Plateletcrit; BRCA cis rs765787 0.556 rs2413778 chr15:45539397 C/A cg24006582 chr15:45444508 DUOX1 -0.56 -11.54 -0.42 4.12e-28 Uric acid levels; BRCA cis rs7762018 0.941 rs4716384 chr6:170109184 T/A cg19338460 chr6:170058176 WDR27 -0.45 -8.0 -0.3 5.76e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs9473147 0.516 rs9349416 chr6:47551938 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.92e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs7613875 0.620 rs7430334 chr3:50078221 T/C cg14019146 chr3:50243930 SLC38A3 0.36 8.96 0.33 3.53e-18 Body mass index; BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg24549020 chr5:56110836 MAP3K1 0.64 13.12 0.46 5.31e-35 Initial pursuit acceleration; BRCA cis rs7927771 0.864 rs2293580 chr11:47440283 T/A cg20307385 chr11:47447363 PSMC3 0.42 9.23 0.34 3.77e-19 Subjective well-being; BRCA cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg15145296 chr3:125709740 NA -0.55 -8.81 -0.33 1.22e-17 Blood pressure (smoking interaction); BRCA cis rs867371 1.000 rs881308 chr15:82475797 A/G cg00614314 chr15:82944287 LOC80154 0.43 9.09 0.34 1.21e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs2576037 0.526 rs8095373 chr18:44527895 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.54 12.04 0.43 3.26e-30 Personality dimensions; BRCA cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg18132916 chr6:79620363 NA -0.43 -9.8 -0.36 3.27e-21 Intelligence (multi-trait analysis); BRCA trans rs1974653 0.918 rs9606250 chr22:20090192 A/T cg20152630 chr19:46405944 MYPOP 0.48 9.83 0.36 2.38e-21 Schizophrenia; BRCA cis rs965469 0.779 rs2236119 chr20:3303576 G/T cg25506879 chr20:3388711 C20orf194 -0.43 -8.65 -0.32 4.13e-17 IFN-related cytopenia; BRCA cis rs9443645 0.901 rs9361480 chr6:79724429 C/T cg18132916 chr6:79620363 NA -0.46 -10.05 -0.37 3.68e-22 Intelligence (multi-trait analysis); BRCA cis rs6860806 0.661 rs4705929 chr5:131584178 G/T cg11843238 chr5:131593191 PDLIM4 0.34 9.04 0.34 1.85e-18 Breast cancer; BRCA cis rs12618769 0.652 rs17506535 chr2:99222834 G/C cg10123293 chr2:99228465 UNC50 0.44 8.71 0.33 2.51e-17 Bipolar disorder; BRCA cis rs6714710 0.603 rs34974566 chr2:98552299 C/G cg26665480 chr2:98280029 ACTR1B 0.59 13.57 0.47 4.65e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs4588572 0.644 rs2115435 chr5:77723700 A/C cg11547950 chr5:77652471 NA -0.44 -8.54 -0.32 9.65e-17 Triglycerides; BRCA cis rs1707322 1.000 rs4660889 chr1:46297331 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.78 0.39 5.39e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs921968 0.565 rs4672897 chr2:219588134 A/G cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 9.26e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs3772130 0.962 rs13061326 chr3:121493125 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.68 0.39 1.31e-24 Cognitive performance; BRCA cis rs4423214 0.840 rs4435028 chr11:71183690 C/A cg05163923 chr11:71159392 DHCR7 -0.56 -11.35 -0.41 2.58e-27 Vitamin D levels; BRCA cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg13770153 chr20:60521292 NA -0.55 -12.01 -0.43 4.17e-30 Body mass index; BRCA cis rs6748734 0.901 rs6720357 chr2:241830296 A/C cg02820040 chr2:241836501 C2orf54 -0.54 -10.25 -0.38 6.25e-23 Urinary metabolites; BRCA cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs10504229 1.000 rs77823122 chr8:58170161 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.7 -0.36 7.54e-21 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.4 8.12 0.31 2.38e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg07395648 chr5:131743802 NA -0.36 -7.98 -0.3 6.73e-15 Breast cancer; BRCA cis rs3806843 0.966 rs6579965 chr5:140168811 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.67e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs13191362 1.000 rs35017019 chr6:162982581 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.53 8.77 0.33 1.57e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7824557 0.606 rs2736273 chr8:11199938 C/A cg06636001 chr8:8085503 FLJ10661 0.51 11.08 0.4 3.26e-26 Retinal vascular caliber; BRCA cis rs67478160 0.643 rs2223937 chr14:104286380 A/G cg26031613 chr14:104095156 KLC1 -0.43 -8.48 -0.32 1.58e-16 Schizophrenia; BRCA cis rs780096 0.587 rs1049817 chr2:27550967 A/G cg22903471 chr2:27725779 GCKR -0.34 -8.13 -0.31 2.3e-15 Total body bone mineral density; BRCA cis rs12995491 0.731 rs56188884 chr2:88508657 G/A cg04511125 chr2:88470314 THNSL2 -0.53 -10.97 -0.4 8.63e-26 Response to metformin (IC50); BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg16606324 chr3:10149918 C3orf24 0.5 10.02 0.37 4.84e-22 Alzheimer's disease; BRCA cis rs6594713 0.921 rs34316732 chr5:112699627 T/C cg12552261 chr5:112820674 MCC 0.47 7.86 0.3 1.63e-14 Brain cytoarchitecture; BRCA cis rs4711336 1.000 rs2229642 chr6:33659472 C/G cg14003231 chr6:33640908 ITPR3 0.32 7.84 0.3 1.92e-14 Height; BRCA cis rs6570726 0.791 rs9403729 chr6:145907007 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.24 0.31 1.01e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2276314 1.000 rs2298716 chr18:33552598 C/T cg19628046 chr18:33552617 C18orf21 0.63 12.98 0.46 2.24e-34 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs17345786 0.906 rs72944107 chr3:101197190 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.56 11.47 0.41 7.87e-28 Colonoscopy-negative controls vs population controls; BRCA trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.32 8.9 0.33 5.72e-18 Intelligence (multi-trait analysis); BRCA trans rs2204008 0.728 rs12369538 chr12:38443942 C/T cg06521331 chr12:34319734 NA -0.43 -7.82 -0.3 2.16e-14 Bladder cancer; BRCA cis rs2066819 1.000 rs77032009 chr12:56679971 A/G cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs9463078 0.547 rs720576 chr6:44729974 A/T cg25276700 chr6:44698697 NA 0.36 8.29 0.31 6.81e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6964587 1.000 rs2282975 chr7:91761638 A/G cg01689657 chr7:91764605 CYP51A1 0.22 7.96 0.3 7.72e-15 Breast cancer; BRCA cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2268241 0.938 rs11088251 chr21:34770810 A/C cg14850771 chr21:34775459 IFNGR2 0.81 16.7 0.55 3.34e-52 Obesity-related traits; BRCA cis rs4819052 0.851 rs2236444 chr21:46678226 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.16 0.34 6.94e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7246657 0.653 rs10425441 chr19:37670648 T/C cg23950597 chr19:37808831 NA -0.67 -10.31 -0.38 3.57e-23 Coronary artery calcification; BRCA cis rs2839186 0.632 rs2839184 chr21:47689013 G/A cg09417038 chr21:47716443 C21orf57 -0.32 -8.01 -0.3 5.61e-15 Testicular germ cell tumor; BRCA cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg18230493 chr5:56204884 C5orf35 -0.72 -14.03 -0.49 3.47e-39 Initial pursuit acceleration; BRCA cis rs651907 0.617 rs797776 chr3:101610243 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.39 9.0 0.34 2.52e-18 Colorectal cancer; BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.62 10.0 0.37 5.63e-22 Renal function-related traits (BUN); BRCA cis rs7072216 0.763 rs10748730 chr10:100171440 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 9.24e-21 Metabolite levels; BRCA cis rs9649213 0.593 rs7789380 chr7:97956180 G/A cg24562669 chr7:97807699 LMTK2 0.43 11.68 0.42 1.02e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs6878727 0.850 rs11241738 chr5:123721425 A/T cg01806427 chr5:123737813 NA 0.4 9.04 0.34 1.88e-18 Breast cancer; BRCA cis rs425277 1.000 rs385039 chr1:2077409 C/T cg24578937 chr1:2090814 PRKCZ -0.57 -17.77 -0.58 1.03e-57 Height; BRCA cis rs8062405 1.000 rs7187776 chr16:28857645 A/G cg16576597 chr16:28551801 NUPR1 0.27 7.94 0.3 9.22e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs629535 0.508 rs56207225 chr8:70146628 C/A cg21567404 chr3:27674614 NA -0.96 -17.44 -0.57 5.27e-56 Dupuytren's disease; BRCA cis rs10256972 0.900 rs7812072 chr7:1053862 A/G cg07308232 chr7:1071921 C7orf50 -0.42 -8.59 -0.32 6.89e-17 Longevity;Endometriosis; BRCA cis rs9790314 0.846 rs4856714 chr3:160961824 T/C cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA cis rs2180341 1.000 rs3798850 chr6:127613966 C/T cg24812749 chr6:127587940 RNF146 0.88 20.63 0.63 7.68e-73 Breast cancer; BRCA cis rs11123170 0.503 rs28679654 chr2:113967617 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.55 9.07 0.34 1.47e-18 Renal function-related traits (BUN); BRCA cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.35 0.41 2.43e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs8114671 0.869 rs2038503 chr20:33675900 G/A cg07148914 chr20:33460835 GGT7 -0.42 -9.04 -0.34 1.92e-18 Height; BRCA cis rs2066819 1.000 rs79824801 chr12:56728137 T/C cg26714650 chr12:56694279 CS -1.19 -15.73 -0.53 2.35e-47 Psoriasis vulgaris; BRCA cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.29 -0.38 4.51e-23 Reticulocyte count; BRCA cis rs72781680 0.528 rs56258075 chr2:24104256 C/G cg08917208 chr2:24149416 ATAD2B 0.93 13.75 0.48 7.07e-38 Lymphocyte counts; BRCA cis rs6570726 0.738 rs6925594 chr6:145898454 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.83e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs924607 0.898 rs1697990 chr5:626278 A/G cg09021430 chr5:549028 NA 0.44 12.88 0.45 6.82e-34 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA trans rs9325144 0.510 rs6582599 chr12:38715965 T/G cg23762105 chr12:34175262 ALG10 -0.41 -10.1 -0.37 2.42e-22 Morning vs. evening chronotype; BRCA cis rs7772486 0.790 rs1062067 chr6:146207563 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.38 -0.35 1.12e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs651907 0.514 rs55654108 chr3:101425703 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.22 0.49 4.65e-40 Colorectal cancer; BRCA cis rs35146811 0.735 rs1727138 chr7:99815247 A/G cg13334819 chr7:99746414 C7orf59 0.34 7.9 0.3 1.25e-14 Coronary artery disease; BRCA cis rs2836974 0.899 rs8127087 chr21:40544502 C/T cg11644478 chr21:40555479 PSMG1 0.82 18.71 0.59 1.22e-62 Cognitive function; BRCA cis rs11734570 0.581 rs4401459 chr4:38585268 G/T cg18361445 chr4:38666374 KLF3;FLJ13197 -0.48 -8.82 -0.33 1.05e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2073300 0.609 rs6137919 chr20:23363163 T/C cg12062639 chr20:23401060 NAPB 0.96 13.45 0.47 1.64e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs526821 0.553 rs510095 chr11:55289154 T/C cg11707556 chr5:10655725 ANKRD33B -0.37 -8.23 -0.31 1.03e-15 Pediatric bone mineral density (spine); BRCA cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg22800045 chr5:56110881 MAP3K1 0.6 10.27 0.38 5.43e-23 Initial pursuit acceleration; BRCA cis rs826838 0.967 rs7299170 chr12:38789536 G/A cg13010199 chr12:38710504 ALG10B 0.54 11.98 0.43 5.39e-30 Heart rate; BRCA cis rs4671400 0.571 rs2421116 chr2:61488411 A/G cg15711740 chr2:61764176 XPO1 0.43 9.03 0.34 2.02e-18 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs13118159 0.550 rs2878607 chr4:1353310 G/C cg05025164 chr4:1340916 KIAA1530 0.76 15.54 0.52 1.92e-46 Longevity; BRCA cis rs2115630 1.000 rs2879828 chr15:85361977 G/T cg11189052 chr15:85197271 WDR73 -0.35 -8.38 -0.31 3.42e-16 P wave terminal force; BRCA cis rs7481584 0.581 rs515481 chr11:3047184 A/G cg08508325 chr11:3079039 CARS 0.28 8.5 0.32 1.38e-16 Calcium levels; BRCA cis rs7707921 0.522 rs10070637 chr5:81490608 A/G cg15871215 chr5:81402204 ATG10 0.35 8.82 0.33 1.1e-17 Breast cancer; BRCA cis rs9811920 0.809 rs766778 chr3:99751480 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.57 -13.67 -0.48 1.72e-37 Axial length; BRCA cis rs10992471 0.528 rs4744135 chr9:95251874 A/C cg14631576 chr9:95140430 CENPP 0.34 8.43 0.32 2.29e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs1018836 0.663 rs2205151 chr8:91483468 A/C cg16814680 chr8:91681699 NA -0.48 -10.15 -0.37 1.49e-22 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.590 rs1560865 chr2:26452197 C/A cg04944784 chr2:26401820 FAM59B -0.95 -16.58 -0.55 1.26e-51 Gut microbiome composition (summer); BRCA cis rs2797160 1.000 rs1739348 chr6:126014573 T/C cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.2e-20 Endometrial cancer; BRCA cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg11941060 chr3:133502564 NA -0.5 -12.1 -0.43 1.67e-30 Iron status biomarkers; BRCA cis rs2576037 0.899 rs2060417 chr18:44576486 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -8.66 -0.32 3.7e-17 Personality dimensions; BRCA cis rs10046574 0.831 rs7785527 chr7:135063685 C/T cg27474649 chr7:135195673 CNOT4 0.58 8.3 0.31 6.41e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg24549020 chr5:56110836 MAP3K1 -0.46 -9.83 -0.36 2.47e-21 Type 2 diabetes; BRCA cis rs250677 0.687 rs384979 chr5:148459267 C/T cg18129178 chr5:148520854 ABLIM3 0.6 12.37 0.44 1.11e-31 Breast cancer; BRCA cis rs10845606 1.000 rs11055013 chr12:12829037 T/C cg04607235 chr12:12878440 APOLD1 -0.62 -10.02 -0.37 4.86e-22 Systemic lupus erythematosus; BRCA cis rs875971 1.000 rs778706 chr7:65860424 A/G cg18876405 chr7:65276391 NA 0.56 13.34 0.47 5.75e-36 Aortic root size; BRCA cis rs1941023 0.503 rs12798266 chr11:60118851 G/A cg08716584 chr11:60157161 MS4A7 -0.41 -9.65 -0.36 1.16e-20 Congenital heart disease (maternal effect); BRCA cis rs17401966 1.000 rs1536263 chr1:10378914 T/C cg03954927 chr1:10346856 KIF1B 0.45 12.82 0.45 1.19e-33 Hepatocellular carcinoma; BRCA cis rs6942756 0.955 rs9641849 chr7:128899238 C/T cg02491457 chr7:128862824 NA -0.69 -13.61 -0.47 3.23e-37 White matter hyperintensity burden; BRCA cis rs7246657 0.943 rs7255972 chr19:37933841 T/C cg18154014 chr19:37997991 ZNF793 0.62 11.63 0.42 1.75e-28 Coronary artery calcification; BRCA trans rs61931739 0.500 rs7965679 chr12:34542494 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA cis rs6433895 1.000 rs34601234 chr2:182013120 T/G cg00481216 chr2:181971175 NA 0.37 8.72 0.33 2.49e-17 Lymphocyte counts; BRCA cis rs67478160 0.643 rs6575999 chr14:104250609 C/G cg01849466 chr14:104193079 ZFYVE21 -0.45 -11.77 -0.42 4.22e-29 Schizophrenia; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg08470875 chr2:26401718 FAM59B 0.72 11.89 0.43 1.31e-29 Gut microbiome composition (summer); BRCA cis rs6963495 0.556 rs818481 chr7:105158467 G/C cg19920283 chr7:105172520 RINT1 0.44 9.12 0.34 9.93e-19 Bipolar disorder (body mass index interaction); BRCA cis rs10751667 0.643 rs7942693 chr11:957832 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.22e-52 Alzheimer's disease (late onset); BRCA cis rs2191566 0.576 rs395803 chr19:44494694 A/G cg20607764 chr19:44506953 ZNF230 0.37 8.01 0.3 5.57e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 16.67 0.55 4.65e-52 Alzheimer's disease; BRCA cis rs7666738 0.830 rs13130923 chr4:99046281 T/C cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9369695 0.883 rs9473128 chr6:47505010 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.71 0.36 7.19e-21 Reticulocyte count; BRCA cis rs17253792 0.822 rs78143160 chr14:56150097 A/G cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.2e-19 Putamen volume; BRCA cis rs763014 0.932 rs35067229 chr16:649638 T/C cg09256448 chr16:638327 NA 0.31 8.45 0.32 1.91e-16 Height; BRCA cis rs12579753 0.956 rs35278765 chr12:82173126 T/C cg07988820 chr12:82153109 PPFIA2 -0.65 -10.39 -0.38 1.86e-23 Resting heart rate; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg23708337 chr7:1209742 NA 0.44 8.66 0.32 3.93e-17 Longevity;Endometriosis; BRCA cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg24642439 chr20:33292090 TP53INP2 0.43 9.19 0.34 5.43e-19 Height; BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg22920501 chr2:26401640 FAM59B 0.91 16.27 0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs11792861 0.926 rs59904140 chr9:111910051 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.43 8.16 0.31 1.84e-15 Menarche (age at onset); BRCA cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg15017067 chr4:17643749 FAM184B -0.27 -7.99 -0.3 6.5e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs526821 0.595 rs485555 chr11:55323570 A/G cg11707556 chr5:10655725 ANKRD33B 0.37 8.3 0.31 6.37e-16 Pediatric bone mineral density (spine); BRCA cis rs7618915 0.501 rs7611731 chr3:52692721 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.29 0.41 4.47e-27 Bipolar disorder; BRCA cis rs875971 0.508 rs10242423 chr7:66059175 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -8.96 -0.33 3.47e-18 Aortic root size; BRCA cis rs1355223 0.583 rs2915238 chr11:34884405 C/A cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.33 -0.35 1.72e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg24812749 chr6:127587940 RNF146 0.88 20.63 0.63 7.68e-73 Breast cancer; BRCA trans rs61931739 0.534 rs1586410 chr12:33999142 C/T cg13010199 chr12:38710504 ALG10B 0.47 8.99 0.34 2.82e-18 Morning vs. evening chronotype; BRCA cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg06627557 chr7:32535165 LSM5;AVL9 1.06 27.25 0.73 4.36e-109 Cognitive ability; BRCA cis rs6543140 0.927 rs917999 chr2:103067869 G/A cg04239558 chr2:103089729 SLC9A4 0.34 9.55 0.35 2.73e-20 Blood protein levels; BRCA cis rs2795502 1.000 rs3121279 chr10:43378449 T/A cg20628663 chr10:43360327 NA 0.65 13.31 0.47 7.84e-36 Blood protein levels; BRCA cis rs752010 0.645 rs1109254 chr1:42091770 T/C cg06885757 chr1:42089581 HIVEP3 0.41 13.38 0.47 3.72e-36 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg03517284 chr6:25882590 NA -0.38 -8.25 -0.31 9.11e-16 Intelligence (multi-trait analysis); BRCA cis rs4820539 1.000 rs13054985 chr22:23458577 G/A cg14186256 chr22:23484241 RTDR1 0.75 22.02 0.66 2.19e-80 Bone mineral density; BRCA cis rs933688 1.000 rs61612071 chr5:90741470 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 19.65 0.61 1.3e-67 Smoking behavior; BRCA cis rs61931739 0.517 rs11611190 chr12:34015697 G/A cg06521331 chr12:34319734 NA -0.62 -11.23 -0.41 7.8e-27 Morning vs. evening chronotype; BRCA cis rs698813 0.614 rs811494 chr2:44725047 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.44 8.36 0.31 3.85e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs4563143 0.675 rs73029042 chr19:29267979 A/T cg12756686 chr19:29218302 NA 0.57 10.98 0.4 8.46e-26 Methadone dose in opioid dependence; BRCA cis rs3862260 0.509 rs2281493 chr1:120162787 T/C cg11530693 chr1:120165357 ZNF697 0.62 14.77 0.5 1.1e-42 Systemic lupus erythematosus; BRCA cis rs10206020 0.885 rs11899557 chr2:1576123 G/T cg12573674 chr2:1569213 NA -0.58 -12.54 -0.44 2.11e-32 IgG glycosylation; BRCA cis rs763121 0.853 rs5757231 chr22:39071658 C/T cg06022373 chr22:39101656 GTPBP1 -0.73 -17.88 -0.58 2.92e-58 Menopause (age at onset); BRCA cis rs11249608 0.548 rs6894076 chr5:178449813 T/C cg21905437 chr5:178450457 ZNF879 0.52 10.85 0.39 2.68e-25 Pubertal anthropometrics; BRCA cis rs7772486 0.727 rs6941429 chr6:145952283 G/A cg13319975 chr6:146136371 FBXO30 -0.43 -9.83 -0.36 2.42e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs637571 0.522 rs566590 chr11:65754062 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.59 13.3 0.47 8.2e-36 Eosinophil percentage of white cells; BRCA cis rs10899021 1.000 rs61900635 chr11:74359010 C/G cg25880958 chr11:74394337 NA -0.52 -8.05 -0.3 4e-15 Response to metformin (IC50); BRCA cis rs1371867 0.846 rs1660330 chr8:101305015 T/A cg06636551 chr8:101224915 SPAG1 -0.38 -8.72 -0.33 2.39e-17 Atrioventricular conduction; BRCA cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg02073558 chr3:44770973 ZNF501 0.38 7.94 0.3 9.25e-15 Depressive symptoms; BRCA cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg14963724 chr18:72166303 CNDP2 -0.34 -9.54 -0.35 3.05e-20 Refractive error; BRCA cis rs2066819 1.000 rs744051 chr12:56667298 C/T cg26714650 chr12:56694279 CS 1.16 15.27 0.52 3.93e-45 Psoriasis vulgaris; BRCA cis rs861020 0.771 rs654470 chr1:210014093 A/T cg05527609 chr1:210001259 C1orf107 0.84 20.09 0.62 5.66e-70 Orofacial clefts; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg15242686 chr22:24348715 GSTTP1 0.32 7.97 0.3 7.43e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs400736 0.655 rs11121086 chr1:8151224 C/T cg25007680 chr1:8021821 PARK7 -0.35 -8.53 -0.32 1.02e-16 Response to antidepressants and depression; BRCA cis rs782590 0.729 rs706548 chr2:55850106 C/G cg18811423 chr2:55921094 PNPT1 0.59 16.38 0.54 1.38e-50 Metabolic syndrome; BRCA cis rs1994135 0.586 rs7308214 chr12:33713834 T/A cg06521331 chr12:34319734 NA -0.5 -9.09 -0.34 1.26e-18 Resting heart rate; BRCA cis rs875971 0.895 rs10755833 chr7:65913917 A/G cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs919433 0.679 rs9967823 chr2:198531529 A/G cg00792783 chr2:198669748 PLCL1 0.4 9.19 0.34 5.63e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9611519 0.929 rs13055800 chr22:41440424 G/A cg03806693 chr22:41940476 POLR3H -0.55 -9.71 -0.36 6.86e-21 Neuroticism; BRCA cis rs55665837 1.000 rs10832254 chr11:14434698 A/G cg19336497 chr11:14380999 RRAS2 -0.36 -9.49 -0.35 4.37e-20 Vitamin D levels; BRCA cis rs10504229 0.516 rs60398072 chr8:58086559 G/A cg20607798 chr8:58055168 NA 0.46 9.85 0.36 2.14e-21 Developmental language disorder (linguistic errors); BRCA cis rs9467711 0.591 rs35249036 chr6:26026163 C/G cg21479132 chr6:26055353 NA 0.57 8.03 0.3 4.79e-15 Autism spectrum disorder or schizophrenia; BRCA trans rs35110281 0.591 rs162369 chr21:44931965 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.18 0.34 5.71e-19 Mean corpuscular volume; BRCA cis rs7927771 0.524 rs12785949 chr11:47729770 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.58 0.35 2.07e-20 Subjective well-being; BRCA cis rs1552244 0.572 rs57268864 chr3:10164233 C/A cg16606324 chr3:10149918 C3orf24 0.57 10.0 0.37 5.57e-22 Alzheimer's disease; BRCA cis rs765787 0.530 rs12906537 chr15:45520061 T/C cg25801113 chr15:45476975 SHF -0.34 -8.23 -0.31 1.07e-15 Uric acid levels; BRCA cis rs7178424 0.967 rs8039105 chr15:62359085 C/T cg00456672 chr15:62358751 C2CD4A -0.42 -9.51 -0.35 3.88e-20 Height; BRCA cis rs1030877 0.557 rs2576752 chr2:105978761 A/G cg02079111 chr2:105885981 TGFBRAP1 0.49 10.92 0.4 1.41e-25 Obesity-related traits; BRCA cis rs35306767 0.903 rs7067865 chr10:908387 C/T cg20503657 chr10:835505 NA 1.03 18.12 0.58 1.6e-59 Eosinophil percentage of granulocytes; BRCA cis rs6964587 0.967 rs28399886 chr7:91638451 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.95e-15 Breast cancer; BRCA cis rs11190604 1.000 rs11190570 chr10:102227702 G/C cg07080220 chr10:102295463 HIF1AN 0.48 11.01 0.4 5.96e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7772486 0.875 rs13204280 chr6:146415368 T/C cg23711669 chr6:146136114 FBXO30 0.73 17.0 0.56 1e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs9527 0.545 rs7894588 chr10:104756030 A/T cg04362960 chr10:104952993 NT5C2 0.37 8.25 0.31 9.05e-16 Arsenic metabolism; BRCA cis rs4363385 0.818 rs679378 chr1:153011716 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.44 -0.32 2.1e-16 Inflammatory skin disease; BRCA trans rs3857536 0.813 rs6455084 chr6:66935658 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg13047869 chr3:10149882 C3orf24 0.57 10.45 0.38 1.08e-23 Alzheimer's disease; BRCA cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg04450456 chr4:17643702 FAM184B 0.36 10.34 0.38 2.88e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs6479891 1.000 rs1904295 chr10:64982876 G/A cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.58e-16 Arthritis (juvenile idiopathic); BRCA trans rs877282 0.853 rs7083589 chr10:754494 G/A cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs11229555 0.645 rs12800531 chr11:58180099 C/T cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg12444411 chr7:2802554 GNA12 -0.33 -8.55 -0.32 8.94e-17 Height; BRCA cis rs9467711 0.591 rs13201821 chr6:26057781 A/C cg21479132 chr6:26055353 NA 0.56 7.94 0.3 9.43e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg04944784 chr2:26401820 FAM59B -0.66 -11.29 -0.41 4.4e-27 Gut microbiome composition (summer); BRCA trans rs7980799 0.649 rs11559754 chr12:33649229 G/A cg26384229 chr12:38710491 ALG10B -0.44 -9.63 -0.36 1.4e-20 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs7615952 0.599 rs66532274 chr3:125731845 G/A cg18479299 chr3:125709523 NA -0.53 -9.11 -0.34 1.07e-18 Blood pressure (smoking interaction); BRCA cis rs2842992 0.830 rs2842974 chr6:160159034 C/T cg11366901 chr6:160182831 ACAT2 0.82 15.94 0.53 2.09e-48 Age-related macular degeneration (geographic atrophy); BRCA cis rs873946 0.586 rs12259688 chr10:134549628 A/G cg06453172 chr10:134556979 INPP5A -0.59 -12.4 -0.44 8.87e-32 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg21535247 chr6:8435926 SLC35B3 -0.4 -9.16 -0.34 6.93e-19 Motion sickness; BRCA cis rs12142240 0.692 rs7529674 chr1:46818508 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs1008375 0.932 rs12500947 chr4:17603424 C/T cg02297831 chr4:17616191 MED28 0.36 8.4 0.32 2.9e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8072100 0.840 rs2136751 chr17:45456093 A/G cg25173405 chr17:45401733 C17orf57 -0.57 -12.24 -0.44 4.26e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2153535 0.580 rs9393025 chr6:8490618 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.74e-18 Motion sickness; BRCA cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg05347473 chr6:146136440 FBXO30 0.42 8.39 0.32 3.1e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg21747090 chr2:27597821 SNX17 -0.41 -9.05 -0.34 1.72e-18 Total body bone mineral density; BRCA cis rs3858526 0.796 rs9645652 chr11:5944264 C/T cg05234568 chr11:5960015 NA -0.47 -9.45 -0.35 6.54e-20 DNA methylation (variation); BRCA trans rs9858542 1.000 rs6770670 chr3:49686682 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -9.83 -0.36 2.39e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7927592 0.913 rs3740629 chr11:68343593 C/T cg20283391 chr11:68216788 NA -0.46 -8.97 -0.33 3.25e-18 Total body bone mineral density; BRCA cis rs1371867 0.846 rs1788194 chr8:101277916 T/C cg06636551 chr8:101224915 SPAG1 -0.38 -8.52 -0.32 1.18e-16 Atrioventricular conduction; BRCA cis rs6429082 0.818 rs291386 chr1:235647050 C/T cg26050004 chr1:235667680 B3GALNT2 0.54 12.85 0.45 8.53e-34 Adiposity; BRCA cis rs4237845 0.844 rs4628718 chr12:58301600 A/C cg02175503 chr12:58329896 NA 0.55 11.54 0.42 4.13e-28 Intelligence (multi-trait analysis); BRCA cis rs6867032 0.917 rs10474733 chr5:2004160 A/G cg26168224 chr5:2018326 NA -0.61 -15.84 -0.53 6.49e-48 Gut microbiome composition (winter); BRCA cis rs9733 0.650 rs4970923 chr1:150608300 A/G cg18016565 chr1:150552671 MCL1 -0.43 -9.61 -0.36 1.62e-20 Tonsillectomy; BRCA cis rs17376456 0.877 rs67066109 chr5:93494101 G/C cg25358565 chr5:93447407 FAM172A 1.16 18.34 0.59 1.15e-60 Diabetic retinopathy; BRCA cis rs9868809 0.505 rs11708786 chr3:48752654 C/T cg07636037 chr3:49044803 WDR6 -0.56 -8.05 -0.3 3.95e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2836974 0.965 rs8134733 chr21:40683459 C/T cg11644478 chr21:40555479 PSMG1 0.83 18.42 0.59 4.11e-61 Cognitive function; BRCA cis rs6912958 0.712 rs6930600 chr6:88349787 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.3 -0.31 6.13e-16 Monocyte percentage of white cells; BRCA cis rs2072499 1.000 rs2241107 chr1:156182710 C/T cg25208724 chr1:156163844 SLC25A44 -1.0 -32.73 -0.79 1.03e-138 Testicular germ cell tumor; BRCA trans rs12310956 0.532 rs11052930 chr12:33964824 A/G cg26384229 chr12:38710491 ALG10B 0.66 13.95 0.48 8.57e-39 Morning vs. evening chronotype; BRCA cis rs769267 0.965 rs6511026 chr19:19391402 C/T cg01262667 chr19:19385393 TM6SF2 0.42 10.97 0.4 9.28e-26 Tonsillectomy; BRCA cis rs7666738 0.791 rs17549003 chr4:98969132 A/C cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.57 -0.42 2.97e-28 Gut microbiome composition (summer); BRCA cis rs2153535 0.580 rs9392220 chr6:8457946 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.34 0.38 2.78e-23 Motion sickness; BRCA cis rs9595066 0.715 rs9567366 chr13:44682973 A/C cg04068111 chr13:44716778 NA 0.44 8.69 0.33 2.97e-17 Schizophrenia; BRCA trans rs11165623 0.765 rs12749081 chr1:96970371 A/C cg10631902 chr5:14652156 NA -0.5 -15.57 -0.52 1.48e-46 Hip circumference;Waist circumference; BRCA cis rs739401 0.611 rs417957 chr11:3046231 A/G cg08508325 chr11:3079039 CARS -0.42 -14.93 -0.51 1.93e-43 Longevity; BRCA cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs2625529 0.824 rs4445848 chr15:72354598 C/T cg16672083 chr15:72433130 SENP8 -0.84 -17.45 -0.57 4.66e-56 Red blood cell count; BRCA cis rs9311474 0.713 rs352167 chr3:52238656 C/T cg15698299 chr3:52233019 ALAS1 0.4 9.42 0.35 7.93e-20 Electroencephalogram traits; BRCA cis rs17601876 0.814 rs2899474 chr15:51562076 C/T cg19946085 chr15:51559439 CYP19A1 -0.39 -11.65 -0.42 1.47e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs2832191 0.716 rs1984012 chr21:30392472 T/C cg08807101 chr21:30365312 RNF160 0.76 20.08 0.62 6.32e-70 Dental caries; BRCA cis rs9457247 0.508 rs7760495 chr6:167506795 C/T cg07741184 chr6:167504864 NA 0.32 9.77 0.36 4.12e-21 Crohn's disease; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg03885332 chr11:832357 CD151 -0.34 -9.4 -0.35 9.62e-20 Mean platelet volume; BRCA cis rs6545883 0.859 rs7561672 chr2:61519094 G/A cg15711740 chr2:61764176 XPO1 0.49 12.13 0.43 1.23e-30 Tuberculosis; BRCA cis rs875971 0.862 rs10263690 chr7:65766453 G/C cg11764359 chr7:65958608 NA -0.75 -16.87 -0.55 4.61e-53 Aortic root size; BRCA cis rs780096 0.565 rs11681351 chr2:27743423 G/A cg12648201 chr2:27665141 KRTCAP3 -0.33 -8.03 -0.3 4.66e-15 Total body bone mineral density; BRCA cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 8.57 0.32 7.9e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg03188948 chr7:1209495 NA 0.46 8.9 0.33 5.77e-18 Longevity;Endometriosis; BRCA cis rs35146811 0.961 rs35991721 chr7:99728790 G/T cg13334819 chr7:99746414 C7orf59 -0.47 -10.84 -0.39 3.07e-25 Coronary artery disease; BRCA cis rs3760982 0.585 rs4803659 chr19:44290235 C/T cg11993925 chr19:44307056 LYPD5 0.37 8.81 0.33 1.14e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs9443645 0.901 rs2152951 chr6:79762172 A/G cg05283184 chr6:79620031 NA 0.42 10.89 0.4 1.95e-25 Intelligence (multi-trait analysis); BRCA cis rs11718455 0.767 rs9861276 chr3:43989595 C/T cg08738300 chr3:44038990 NA 0.48 8.9 0.33 5.94e-18 Coronary artery disease; BRCA cis rs763121 0.889 rs4820335 chr22:38935927 C/G cg14440974 chr22:39074834 NA 0.33 8.12 0.31 2.4e-15 Menopause (age at onset); BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg04944784 chr2:26401820 FAM59B -0.68 -11.19 -0.4 1.19e-26 Gut microbiome composition (summer); BRCA cis rs61990749 0.544 rs176979 chr14:78198072 A/C cg02301378 chr14:78227641 SNW1;C14orf178 0.66 10.67 0.39 1.45e-24 Fibroblast growth factor basic levels; BRCA cis rs6088590 1.000 rs6120748 chr20:33458284 T/G cg06115741 chr20:33292138 TP53INP2 0.48 10.48 0.38 8.32e-24 Coronary artery disease; BRCA cis rs7927771 0.864 rs4752999 chr11:47428565 C/T cg18512352 chr11:47633146 NA -0.33 -8.05 -0.3 4.02e-15 Subjective well-being; BRCA cis rs9296092 0.560 rs9469506 chr6:33527897 A/G cg13560919 chr6:33536144 NA -0.85 -18.69 -0.59 1.6e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1949733 1.000 rs1357481 chr4:8496221 A/T cg11789530 chr4:8429930 ACOX3 0.67 17.63 0.57 5.43e-57 Response to antineoplastic agents; BRCA cis rs2832191 0.740 rs2012645 chr21:30445961 G/A cg24692254 chr21:30365293 RNF160 0.78 21.75 0.65 6.72e-79 Dental caries; BRCA cis rs7635838 0.617 rs347587 chr3:11287155 A/G cg00170343 chr3:11313890 ATG7 -0.47 -9.51 -0.35 3.87e-20 HDL cholesterol; BRCA cis rs2625529 0.824 rs2279283 chr15:72243666 T/C cg16672083 chr15:72433130 SENP8 -0.82 -17.0 -0.56 9.76e-54 Red blood cell count; BRCA cis rs12701220 0.522 rs12334290 chr7:1054517 A/G cg04025307 chr7:1156635 C7orf50 0.47 10.86 0.39 2.4e-25 Bronchopulmonary dysplasia; BRCA trans rs11039798 0.920 rs11040013 chr11:48782862 G/A cg15704280 chr7:45808275 SEPT13 0.59 8.75 0.33 1.95e-17 Axial length; BRCA cis rs7666738 0.830 rs13119913 chr4:98977983 G/T cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.98e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs495337 0.760 rs6122844 chr20:48541545 G/T cg17835207 chr20:48524531 SPATA2 -0.69 -16.83 -0.55 6.92e-53 Psoriasis; BRCA cis rs6088580 0.634 rs6059887 chr20:33101102 C/G cg06115741 chr20:33292138 TP53INP2 0.39 8.62 0.32 5.23e-17 Glomerular filtration rate (creatinine); BRCA cis rs12368653 0.557 rs903067 chr12:58011857 G/A cg12615879 chr12:58013172 SLC26A10 -0.31 -8.55 -0.32 9.07e-17 Multiple sclerosis; BRCA cis rs13082711 0.595 rs6778612 chr3:27370789 T/C cg02860705 chr3:27208620 NA -0.58 -11.23 -0.41 7.73e-27 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs875971 0.862 rs1981799 chr7:65955559 T/C cg11764359 chr7:65958608 NA 0.79 19.19 0.6 3.68e-65 Aortic root size; BRCA cis rs7666738 0.830 rs2865977 chr4:99017916 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.97 0.3 7.11e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 1.000 rs4788101 chr16:28867804 C/T cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs4595586 0.545 rs11611625 chr12:39387207 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs12477438 0.520 rs2632283 chr2:99776000 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs10267417 0.603 rs1557772 chr7:19908535 A/C cg05791153 chr7:19748676 TWISTNB 0.43 8.65 0.32 4.04e-17 Night sleep phenotypes; BRCA cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg03405983 chr8:143858548 LYNX1 -0.37 -8.01 -0.3 5.41e-15 Urinary tract infection frequency; BRCA cis rs1401999 0.932 rs4148557 chr3:183733784 A/G cg20387954 chr3:183756860 HTR3D 0.46 10.56 0.39 3.94e-24 Anterior chamber depth; BRCA cis rs798554 0.610 rs1182209 chr7:2808595 C/T cg04166393 chr7:2884313 GNA12 0.38 8.1 0.3 2.89e-15 Height; BRCA cis rs34779708 0.931 rs4934731 chr10:35431636 T/C cg03585969 chr10:35415529 CREM 0.44 9.31 0.35 2.02e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6083 0.571 rs17190678 chr15:58847372 C/G cg05156742 chr15:59063176 FAM63B -0.45 -9.56 -0.35 2.57e-20 Schizophrenia; BRCA cis rs35110281 0.627 rs11701746 chr21:44975137 C/T cg01579765 chr21:45077557 HSF2BP -0.36 -9.8 -0.36 3.23e-21 Mean corpuscular volume; BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.56 -0.68 8.48e-89 Gut microbiome composition (summer); BRCA cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg22676075 chr6:135203613 NA 0.45 8.79 0.33 1.4e-17 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs11622475 1.000 rs2236247 chr14:104378087 C/T cg12183467 chr14:104352244 NA -0.45 -9.84 -0.36 2.18e-21 Bipolar disorder; BRCA cis rs3806843 0.900 rs2563254 chr5:140142701 T/C cg11822812 chr5:140052017 DND1 -0.31 -8.4 -0.32 2.86e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs208520 0.954 rs1468153 chr6:67009054 A/C cg07460842 chr6:66804631 NA 0.75 11.26 0.41 6.05e-27 Exhaled nitric oxide output; BRCA cis rs9837602 1.000 rs6790877 chr3:99779658 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.25 0.41 6.35e-27 Breast cancer; BRCA cis rs7829975 0.533 rs13274028 chr8:8729193 A/C cg15556689 chr8:8085844 FLJ10661 0.42 11.09 0.4 2.98e-26 Mood instability; BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg04166393 chr7:2884313 GNA12 0.51 9.56 0.35 2.48e-20 Height; BRCA cis rs990171 0.560 rs4851548 chr2:102767532 A/G cg22835712 chr2:102737379 NA 0.51 8.03 0.3 4.56e-15 Lymphocyte counts; BRCA cis rs514406 0.929 rs557847 chr1:53333116 A/G cg01802117 chr1:53393560 SCP2 -0.36 -8.26 -0.31 8.3e-16 Monocyte count; BRCA cis rs4819052 1.000 rs733738 chr21:46666396 A/G cg11663144 chr21:46675770 NA 0.44 8.74 0.33 1.99e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs911119 0.955 rs59059917 chr20:23595675 C/T cg16589663 chr20:23618590 CST3 0.46 8.43 0.32 2.31e-16 Chronic kidney disease; BRCA cis rs3091242 0.867 rs602052 chr1:25722206 T/C cg27572855 chr1:25598939 RHD 0.48 13.52 0.47 8.33e-37 Erythrocyte sedimentation rate; BRCA trans rs11098499 0.908 rs28559989 chr4:120386627 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.95 -0.3 8.73e-15 Corneal astigmatism; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.89 -0.33 6e-18 Total body bone mineral density; BRCA cis rs10046574 0.519 rs34274894 chr7:135214725 G/C cg27474649 chr7:135195673 CNOT4 0.64 10.75 0.39 7.17e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs8077889 0.703 rs231531 chr17:41946180 A/C cg26893861 chr17:41843967 DUSP3 0.56 10.21 0.37 9.35e-23 Triglycerides; BRCA cis rs27434 0.583 rs40091 chr5:96154919 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.15e-33 Ankylosing spondylitis; BRCA cis rs6545883 0.772 rs1186709 chr2:61689380 G/A cg15711740 chr2:61764176 XPO1 -0.57 -14.37 -0.49 8.59e-41 Tuberculosis; BRCA cis rs4332037 0.624 rs73046339 chr7:1889300 G/A cg12591125 chr7:1885375 MAD1L1 0.51 8.91 0.33 5.21e-18 Bipolar disorder; BRCA cis rs10464366 0.544 rs4723824 chr7:39153698 T/C cg10621924 chr7:39171070 POU6F2 0.38 8.12 0.31 2.39e-15 IgG glycosylation; BRCA cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg22535103 chr8:58192502 C8orf71 -0.46 -9.05 -0.34 1.75e-18 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg26408565 chr15:76604113 ETFA -0.48 -10.35 -0.38 2.51e-23 Blood metabolite levels; BRCA cis rs3768617 0.528 rs3736888 chr1:183084607 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.72 0.57 1.98e-57 Fuchs's corneal dystrophy; BRCA cis rs344364 0.511 rs1742395 chr16:1955965 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.52 -9.34 -0.35 1.55e-19 Glomerular filtration rate in chronic kidney disease; BRCA trans rs61931739 0.500 rs11053177 chr12:34412829 G/A cg26384229 chr12:38710491 ALG10B 0.58 13.2 0.46 2.26e-35 Morning vs. evening chronotype; BRCA cis rs11098499 0.909 rs79704848 chr4:120309351 T/A cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs881375 0.933 rs7028641 chr9:123691141 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.59 0.32 6.75e-17 Rheumatoid arthritis; BRCA cis rs10463316 0.817 rs6895187 chr5:150775909 G/A cg03212797 chr5:150827313 SLC36A1 -0.42 -8.32 -0.31 5.27e-16 Metabolite levels (Pyroglutamine); BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg05896524 chr21:47604654 C21orf56 0.49 9.98 0.37 6.87e-22 Testicular germ cell tumor; BRCA cis rs425277 0.606 rs262669 chr1:2082489 A/G cg24578937 chr1:2090814 PRKCZ -0.38 -11.55 -0.42 3.55e-28 Height; BRCA cis rs12971120 0.947 rs7241558 chr18:72169267 A/T cg14963724 chr18:72166303 CNDP2 -0.34 -9.44 -0.35 6.73e-20 Refractive error; BRCA cis rs17270561 0.609 rs9393662 chr6:25739670 T/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.81e-18 Iron status biomarkers; BRCA cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.5 0.35 3.99e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs1008375 0.966 rs2872957 chr4:17651757 C/A cg02297831 chr4:17616191 MED28 0.38 8.85 0.33 8.39e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs67311347 0.868 rs10865895 chr3:40378677 C/T cg09455208 chr3:40491958 NA 0.41 9.68 0.36 9.39e-21 Renal cell carcinoma; BRCA cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg08917208 chr2:24149416 ATAD2B 0.89 12.73 0.45 3.15e-33 Lymphocyte counts; BRCA cis rs2439831 0.850 rs12101756 chr15:44053887 A/G cg10011062 chr15:43941034 CATSPER2 -0.53 -7.98 -0.3 6.85e-15 Lung cancer in ever smokers; BRCA cis rs9790314 0.586 rs16832246 chr3:161109916 A/G cg04691961 chr3:161091175 C3orf57 0.38 8.62 0.32 5.18e-17 Morning vs. evening chronotype; BRCA trans rs61931739 0.612 rs2004961 chr12:33994599 A/G cg26384229 chr12:38710491 ALG10B 0.4 9.01 0.34 2.32e-18 Morning vs. evening chronotype; BRCA cis rs12586317 0.547 rs2254990 chr14:35465565 T/C cg16230307 chr14:35515116 FAM177A1 0.73 15.25 0.52 5.11e-45 Psoriasis; BRCA cis rs1005277 0.579 rs2504140 chr10:38387579 T/G cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.76 -0.36 4.38e-21 Developmental language disorder (linguistic errors); BRCA cis rs11098499 0.629 rs28369518 chr4:120271630 T/C cg09307838 chr4:120376055 NA 0.6 13.04 0.46 1.24e-34 Corneal astigmatism; BRCA cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg26647111 chr11:31128758 NA -0.45 -9.79 -0.36 3.41e-21 Red blood cell count; BRCA cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg25427524 chr10:38739819 LOC399744 -0.64 -15.28 -0.52 3.9e-45 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs4440224 chr4:99044924 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.593 rs6969234 chr7:97987986 T/C cg21770322 chr7:97807741 LMTK2 0.45 11.74 0.42 5.91e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs56235845 0.694 rs6860069 chr5:176755841 C/T cg06060754 chr5:176797920 RGS14 0.6 11.21 0.41 9.62e-27 Hemoglobin concentration;Hematocrit; BRCA cis rs1113500 0.933 rs10881500 chr1:108638895 C/T cg06207961 chr1:108661230 NA 0.44 10.82 0.39 3.75e-25 Growth-regulated protein alpha levels; BRCA cis rs2204008 0.558 rs66545149 chr12:38204694 A/G cg26384229 chr12:38710491 ALG10B 0.75 16.26 0.54 5.37e-50 Bladder cancer; BRCA cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg24642439 chr20:33292090 TP53INP2 0.7 16.19 0.54 1.17e-49 Coronary artery disease; BRCA cis rs9837602 1.000 rs35521705 chr3:99716690 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.28 0.41 4.85e-27 Breast cancer; BRCA cis rs870825 0.616 rs28444118 chr4:185621692 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs909674 0.541 rs5757655 chr22:39797178 C/G cg24399712 chr22:39784796 NA 0.59 13.77 0.48 5.85e-38 IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis);IgG glycosylation;IgG digalactosylation phenotypes (multivariate analysis);IgG sialylation phenotypes (multivariate analysis);IgG monogalactosylation phenotypes (multivariate analysis);IgG fucosylation phenotypes (multivariate analysis);IgG N-glycosylation phenotypes (multivariate analysis);IgG disialylation phenotypes (multivariate analysis);IgG galactosylation phenotypes (multivariate analysis);Post bronchodilator FEV1; BRCA cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg26149184 chr10:133730230 NA 0.4 8.08 0.3 3.16e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs11098499 0.909 rs9994810 chr4:120381590 A/G cg25214090 chr10:38739885 LOC399744 0.54 12.59 0.45 1.29e-32 Corneal astigmatism; BRCA cis rs1008375 1.000 rs10939747 chr4:17691166 C/A cg16339924 chr4:17578868 LAP3 0.58 14.07 0.49 2.4e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35740288 0.597 rs12900830 chr15:86326154 T/C cg20737812 chr15:86336631 KLHL25 -0.38 -8.43 -0.32 2.29e-16 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs9649213 0.593 rs6948540 chr7:97960066 A/G cg21770322 chr7:97807741 LMTK2 0.41 10.95 0.4 1.04e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg07828340 chr4:882639 GAK -0.91 -11.62 -0.42 1.92e-28 Intelligence (multi-trait analysis); BRCA cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg01256987 chr12:42539512 GXYLT1 -0.46 -9.21 -0.34 4.74e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2070488 0.804 rs13085153 chr3:38461279 A/G cg24069376 chr3:38537580 EXOG 0.34 9.34 0.35 1.6e-19 Electrocardiographic conduction measures; BRCA cis rs896854 0.967 rs10956933 chr8:95967688 C/G cg26343298 chr8:95960752 TP53INP1 0.29 8.23 0.31 1.05e-15 Type 2 diabetes; BRCA cis rs10504229 0.596 rs6991216 chr8:58115586 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs8177253 1.000 rs1358023 chr3:133484393 T/C cg12373951 chr3:133503437 NA 0.43 10.16 0.37 1.43e-22 Iron status biomarkers; BRCA cis rs4363385 0.747 rs1415971 chr1:152965779 T/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.49 -0.32 1.42e-16 Inflammatory skin disease; BRCA cis rs10751667 1.000 rs7394449 chr11:962190 T/C cg06064525 chr11:970664 AP2A2 -0.33 -9.81 -0.36 2.91e-21 Alzheimer's disease (late onset); BRCA cis rs9814567 1.000 rs7611611 chr3:134307877 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs853679 0.824 rs34712084 chr6:28043828 A/G cg01620082 chr3:125678407 NA -0.59 -8.22 -0.31 1.14e-15 Depression; BRCA cis rs2019137 0.539 rs4849181 chr2:113991970 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.74 16.14 0.54 2.13e-49 Lymphocyte counts; BRCA cis rs16866061 0.515 rs114968850 chr2:225352461 C/G cg22455342 chr2:225449267 CUL3 0.34 9.13 0.34 9.24e-19 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs6952808 0.723 rs55689856 chr7:2037215 G/A cg22963979 chr7:1858916 MAD1L1 -0.37 -7.9 -0.3 1.21e-14 Bipolar disorder and schizophrenia; BRCA cis rs6951245 0.872 rs75493422 chr7:1072890 C/T cg22907277 chr7:1156413 C7orf50 0.59 9.17 0.34 6.51e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg20607798 chr8:58055168 NA 0.47 8.26 0.31 8.19e-16 Developmental language disorder (linguistic errors); BRCA cis rs6582630 0.502 rs3902522 chr12:38271203 T/C cg13010199 chr12:38710504 ALG10B 0.41 8.5 0.32 1.31e-16 Drug-induced liver injury (flucloxacillin); BRCA trans rs61931739 0.500 rs10772163 chr12:34532950 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA cis rs9457247 0.624 rs9457260 chr6:167466665 C/T cg07741184 chr6:167504864 NA 0.36 10.44 0.38 1.12e-23 Crohn's disease; BRCA cis rs708547 0.581 rs781661 chr4:57780307 A/G cg25525207 chr4:57843836 C4orf14;POLR2B 0.42 8.0 0.3 5.78e-15 Response to bleomycin (chromatid breaks); BRCA cis rs3106136 0.527 rs10030586 chr4:95150805 A/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.16 -0.37 1.39e-22 Capecitabine sensitivity; BRCA trans rs208520 0.690 rs3899423 chr6:66835285 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -20.24 -0.63 9.77e-71 Exhaled nitric oxide output; BRCA cis rs6964587 1.000 rs10280927 chr7:91582205 G/A cg17063962 chr7:91808500 NA -0.52 -12.22 -0.44 5.29e-31 Breast cancer; BRCA cis rs4727027 0.933 rs757738 chr7:148872351 T/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.41 9.01 0.34 2.41e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs8103278 1.000 rs7256192 chr19:46338492 G/A cg12641515 chr19:46296257 DMWD -0.54 -11.92 -0.43 1.03e-29 Coronary artery disease; BRCA cis rs4302748 0.909 rs35766501 chr7:36186069 G/A cg24442661 chr7:36192818 EEPD1 0.46 8.73 0.33 2.21e-17 Platelet count; BRCA cis rs11112613 0.713 rs73184084 chr12:105952615 T/A cg03607813 chr12:105948248 NA 0.55 10.43 0.38 1.25e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg08085267 chr17:45401833 C17orf57 -0.56 -11.07 -0.4 3.51e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg06808227 chr14:105710500 BRF1 0.76 15.88 0.53 4.09e-48 Mean platelet volume;Platelet distribution width; BRCA cis rs7772486 0.625 rs9390355 chr6:146112942 C/T cg23711669 chr6:146136114 FBXO30 -0.72 -17.33 -0.57 1.9e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs1577917 0.916 rs12206726 chr6:86499716 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.04 -0.43 3.04e-30 Response to antipsychotic treatment; BRCA cis rs992157 0.710 rs12612347 chr2:219057338 C/T cg00012203 chr2:219082015 ARPC2 -0.72 -16.0 -0.53 1.02e-48 Colorectal cancer; BRCA cis rs3796619 1.000 rs1466214 chr4:1073760 C/T cg27284194 chr4:1044797 NA 0.43 9.38 0.35 1.09e-19 Recombination rate (males); BRCA trans rs61931739 0.534 rs2087128 chr12:34000173 T/C cg26384229 chr12:38710491 ALG10B 0.46 10.09 0.37 2.61e-22 Morning vs. evening chronotype; BRCA cis rs881375 1.000 rs6478484 chr9:123652380 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.02 0.4 5.67e-26 Rheumatoid arthritis; BRCA cis rs4642101 0.618 rs7612317 chr3:12820558 C/T cg05775895 chr3:12838266 CAND2 0.38 8.39 0.32 3.06e-16 QRS complex (12-leadsum); BRCA cis rs3008870 0.755 rs2815360 chr1:67494458 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 13.93 0.48 1.01e-38 Lymphocyte percentage of white cells; BRCA cis rs4787491 0.729 rs11544328 chr16:30037128 A/C cg06326092 chr16:30034487 C16orf92 0.38 9.83 0.36 2.56e-21 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg16325326 chr1:53192061 ZYG11B 0.69 17.17 0.56 1.36e-54 Monocyte count; BRCA cis rs7587476 1.000 rs2121285 chr2:215656168 C/G cg04004882 chr2:215674386 BARD1 -0.55 -10.21 -0.37 8.95e-23 Neuroblastoma; BRCA cis rs4665809 1.000 rs4665309 chr2:26335502 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA trans rs6952808 0.689 rs12668156 chr7:2019875 G/A cg04565464 chr8:145669602 NFKBIL2 0.43 9.49 0.35 4.34e-20 Bipolar disorder and schizophrenia; BRCA cis rs2549003 1.000 rs2070725 chr5:131821788 C/T cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg10664184 chr19:17420304 DDA1 0.36 10.24 0.38 7e-23 Systemic lupus erythematosus; BRCA cis rs7666738 0.830 rs13145011 chr4:98993410 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.84e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4953076 0.613 rs11124981 chr2:44462133 A/T cg04920474 chr2:44395004 PPM1B 0.49 9.96 0.37 7.83e-22 Height; BRCA cis rs6910061 0.750 rs6456870 chr6:11115486 C/T cg27233058 chr6:11094804 LOC221710 0.5 8.51 0.32 1.21e-16 Diabetic kidney disease; BRCA cis rs769267 0.895 rs1858999 chr19:19497669 C/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.42 -8.63 -0.32 4.76e-17 Tonsillectomy; BRCA cis rs2797160 1.000 rs1935772 chr6:125994708 T/C cg05901451 chr6:126070800 HEY2 -0.41 -9.92 -0.37 1.12e-21 Endometrial cancer; BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg00802000 chr16:706648 WDR90 -0.4 -9.22 -0.34 4.21e-19 Height; BRCA cis rs1707322 0.865 rs785501 chr1:46579611 C/T cg03146154 chr1:46216737 IPP -0.42 -8.98 -0.33 3.03e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg24130564 chr14:104152367 KLC1 -0.41 -8.79 -0.33 1.42e-17 Reticulocyte count; BRCA cis rs751728 0.648 rs6922275 chr6:33749739 G/A cg25922239 chr6:33757077 LEMD2 0.5 12.69 0.45 4.58e-33 Crohn's disease; BRCA cis rs933688 0.877 rs1477349 chr5:90707773 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.87 18.8 0.6 4.37e-63 Smoking behavior; BRCA trans rs9951602 0.512 rs12607612 chr18:76651799 G/A cg02800362 chr5:177631904 HNRNPAB 0.77 18.23 0.58 4.3e-60 Obesity-related traits; BRCA cis rs7829975 0.564 rs2921060 chr8:8317817 G/T cg08975724 chr8:8085496 FLJ10661 -0.52 -11.0 -0.4 6.89e-26 Mood instability; BRCA cis rs933688 1.000 rs35712350 chr5:90679519 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.93 20.62 0.63 8.32e-73 Smoking behavior; BRCA cis rs10464366 0.746 rs12674262 chr7:39141728 G/T cg15212455 chr7:39170539 POU6F2 0.46 9.88 0.36 1.64e-21 IgG glycosylation; BRCA cis rs1862618 0.671 rs2591965 chr5:56236176 T/C cg18230493 chr5:56204884 C5orf35 0.59 12.49 0.44 3.58e-32 Initial pursuit acceleration; BRCA cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.62 -0.55 8.18e-52 Axial length; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg04944784 chr2:26401820 FAM59B 0.95 16.58 0.55 1.27e-51 Gut microbiome composition (summer); BRCA cis rs17253792 0.822 rs10083499 chr14:56066590 T/A cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs7246657 0.722 rs11083432 chr19:38182633 A/G cg23950597 chr19:37808831 NA 0.45 7.85 0.3 1.76e-14 Coronary artery calcification; BRCA cis rs17270561 0.609 rs1937127 chr6:25769872 G/T cg17691542 chr6:26056736 HIST1H1C -0.47 -9.32 -0.35 1.8e-19 Iron status biomarkers; BRCA cis rs9649213 0.593 rs12704983 chr7:97927045 G/A cg01877450 chr7:97915802 BRI3 -0.37 -8.48 -0.32 1.57e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs35306767 0.807 rs72778228 chr10:938435 A/G cg20503657 chr10:835505 NA 1.32 21.46 0.65 2.31e-77 Eosinophil percentage of granulocytes; BRCA cis rs12893668 0.572 rs4900591 chr14:104154878 G/A cg26031613 chr14:104095156 KLC1 -0.53 -9.46 -0.35 5.66e-20 Reticulocyte count; BRCA cis rs739401 0.588 rs10219272 chr11:3020789 G/A cg08508325 chr11:3079039 CARS -0.4 -14.16 -0.49 8.42e-40 Longevity; BRCA cis rs7772486 0.754 rs697054 chr6:146003770 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.44 0.32 2.18e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.855 rs35666723 chr10:867346 A/G cg10556349 chr10:835070 NA 0.73 9.89 0.36 1.45e-21 Eosinophil percentage of granulocytes; BRCA cis rs9875589 0.509 rs1488379 chr3:14014719 A/G cg14375111 chr3:14165186 TMEM43;CHCHD4 0.33 8.77 0.33 1.58e-17 Ovarian reserve; BRCA cis rs4595586 0.545 rs2218761 chr12:39393593 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs6846229 chr4:99016546 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs9291683 0.588 rs12506364 chr4:10023448 C/T cg26043149 chr18:55253948 FECH 0.4 8.5 0.32 1.29e-16 Bone mineral density; BRCA cis rs9790314 0.747 rs6789244 chr3:160866230 A/C cg03342759 chr3:160939853 NMD3 -0.57 -12.62 -0.45 9e-33 Morning vs. evening chronotype; BRCA cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg13770153 chr20:60521292 NA -0.56 -12.13 -0.43 1.31e-30 Body mass index; BRCA cis rs8180040 0.764 rs62246375 chr3:47014464 G/A cg16586182 chr3:47516702 SCAP 0.54 11.92 0.43 1e-29 Colorectal cancer; BRCA cis rs8177253 1.000 rs8177247 chr3:133479499 T/G cg16414030 chr3:133502952 NA -0.48 -11.22 -0.41 8.35e-27 Iron status biomarkers; BRCA cis rs477895 0.653 rs11601577 chr11:63928574 C/T cg18225595 chr11:63971243 STIP1 0.53 9.89 0.36 1.44e-21 Mean platelet volume; BRCA cis rs875971 0.502 rs1796227 chr7:66087019 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.56 -10.27 -0.38 5.3e-23 Aortic root size; BRCA cis rs2404602 0.622 rs1567671 chr15:77209200 C/G cg23625390 chr15:77176239 SCAPER -0.53 -12.35 -0.44 1.42e-31 Blood metabolite levels; BRCA cis rs1163251 0.837 rs839612 chr1:120247176 T/C cg19096424 chr1:120255104 PHGDH 0.45 10.44 0.38 1.2e-23 Blood metabolite levels; BRCA cis rs4713675 0.584 rs3818527 chr6:33661035 A/G cg14003231 chr6:33640908 ITPR3 -0.34 -8.46 -0.32 1.78e-16 Plateletcrit; BRCA cis rs2836974 0.932 rs2234543 chr21:40572072 G/A cg11890956 chr21:40555474 PSMG1 1.05 29.98 0.76 6.03e-124 Cognitive function; BRCA cis rs13217239 0.646 rs6456767 chr6:27070543 C/T cg12292205 chr6:26970375 C6orf41 -0.57 -12.69 -0.45 4.35e-33 Schizophrenia; BRCA cis rs1215050 0.791 rs7681599 chr4:98664109 C/T cg05340658 chr4:99064831 C4orf37 -0.44 -10.13 -0.37 1.76e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12477438 0.520 rs6542866 chr2:99764592 T/C cg08885076 chr2:99613938 TSGA10 0.43 10.31 0.38 3.72e-23 Chronic sinus infection; BRCA trans rs6582630 0.537 rs7299661 chr12:38527713 C/T cg06521331 chr12:34319734 NA -0.45 -8.63 -0.32 4.82e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs10754283 0.967 rs10922680 chr1:90101326 C/T cg21401794 chr1:90099060 LRRC8C -0.49 -11.72 -0.42 7.41e-29 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2180341 0.889 rs9321074 chr6:127618019 G/A cg27446573 chr6:127587934 RNF146 0.9 21.07 0.64 2.99e-75 Breast cancer; BRCA cis rs1953600 1.000 rs2789679 chr10:81907884 A/T cg04850286 chr10:81895943 PLAC9 -0.33 -9.56 -0.35 2.56e-20 Sarcoidosis; BRCA cis rs4363385 0.654 rs1129654 chr1:152958238 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.28 -0.34 2.54e-19 Inflammatory skin disease; BRCA cis rs2046867 0.862 rs11922180 chr3:72836119 A/G cg25664220 chr3:72788482 NA 0.53 10.99 0.4 7.19e-26 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg16414030 chr3:133502952 NA 0.34 7.95 0.3 8.32e-15 Alcohol consumption (transferrin glycosylation); BRCA cis rs13191362 1.000 rs73016459 chr6:163066323 C/A cg18825119 chr6:163149453 PACRG;PARK2 0.54 8.14 0.31 2.02e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs490234 0.756 rs2416963 chr9:128241414 C/T cg14078157 chr9:128172775 NA -0.36 -8.47 -0.32 1.75e-16 Mean arterial pressure; BRCA cis rs9325144 0.555 rs2387847 chr12:38687434 C/T cg26384229 chr12:38710491 ALG10B 0.51 13.46 0.47 1.47e-36 Morning vs. evening chronotype; BRCA cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.42 0.5 5.31e-41 Colorectal cancer; BRCA cis rs72781680 0.898 rs7589440 chr2:24038595 G/A cg08917208 chr2:24149416 ATAD2B 0.9 13.14 0.46 4.57e-35 Lymphocyte counts; BRCA cis rs7927771 0.965 rs12364432 chr11:47902883 G/A cg18512352 chr11:47633146 NA -0.34 -8.03 -0.3 4.74e-15 Subjective well-being; BRCA cis rs782590 0.643 rs13032503 chr2:55739093 C/T cg18811423 chr2:55921094 PNPT1 -0.51 -13.23 -0.46 1.67e-35 Metabolic syndrome; BRCA cis rs7618915 0.501 rs3755798 chr3:52741160 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -11.97 -0.43 6.27e-30 Bipolar disorder; BRCA trans rs9747201 0.925 rs11867806 chr17:80072049 A/G cg07393940 chr7:158741817 NA -0.53 -10.13 -0.37 1.8e-22 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6834538 0.577 rs10034556 chr4:113449650 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.43 10.34 0.38 2.83e-23 Free thyroxine concentration; BRCA cis rs2204008 0.837 rs11169157 chr12:37980047 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.2 0.52 9.06e-45 Bladder cancer; BRCA cis rs780096 0.506 rs8395 chr2:27715207 T/A cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.41 -0.32 2.76e-16 Total body bone mineral density; BRCA cis rs939658 0.935 rs34859518 chr15:79450422 A/G cg17916960 chr15:79447300 NA -0.42 -10.48 -0.38 8.07e-24 Refractive error; BRCA cis rs7267979 1.000 rs6115153 chr20:25325567 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.3 -0.35 2.14e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1862618 0.573 rs832532 chr5:56221938 T/C cg24549020 chr5:56110836 MAP3K1 0.56 10.25 0.38 6.16e-23 Initial pursuit acceleration; BRCA cis rs7633857 0.532 rs9839984 chr3:160768912 C/T cg03342759 chr3:160939853 NMD3 -0.58 -12.22 -0.44 5.13e-31 Educational attainment (years of education); BRCA cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.76e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg08219700 chr8:58056026 NA 0.63 10.07 0.37 3.05e-22 Developmental language disorder (linguistic errors); BRCA cis rs1707322 1.000 rs785517 chr1:46567535 A/T cg06784218 chr1:46089804 CCDC17 -0.46 -10.78 -0.39 5.33e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10911363 0.571 rs6424897 chr1:183419203 T/C cg09173681 chr1:183549694 NCF2 -0.48 -10.46 -0.38 9.58e-24 Systemic lupus erythematosus; BRCA cis rs1538970 0.924 rs4660855 chr1:45899795 A/G cg05343316 chr1:45956843 TESK2 0.62 12.54 0.44 1.99e-32 Platelet count; BRCA cis rs17376456 0.825 rs10052662 chr5:93271385 A/G cg25358565 chr5:93447407 FAM172A 1.21 18.91 0.6 1.11e-63 Diabetic retinopathy; BRCA cis rs367943 0.604 rs10477502 chr5:113007126 C/T cg12552261 chr5:112820674 MCC 0.42 8.27 0.31 8.06e-16 Type 2 diabetes; BRCA cis rs7615952 0.515 rs7630575 chr3:125682330 A/G cg05084668 chr3:125655381 ALG1L -0.59 -10.98 -0.4 7.97e-26 Blood pressure (smoking interaction); BRCA cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg24977027 chr2:88469347 THNSL2 0.46 7.98 0.3 6.56e-15 Plasma clusterin levels; BRCA cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 1.01e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7147624 0.882 rs7141367 chr14:65938641 C/T cg03016385 chr14:66212404 NA -0.57 -8.78 -0.33 1.51e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA trans rs2727020 0.857 rs1917324 chr11:49371759 G/C cg15704280 chr7:45808275 SEPT13 -0.73 -14.98 -0.51 1.01e-43 Coronary artery disease; BRCA cis rs4819052 0.851 rs2838836 chr21:46665875 G/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.09 0.49 1.91e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4478858 0.735 rs6679393 chr1:31770944 T/C cg00250761 chr1:31883323 NA -0.32 -8.3 -0.31 6.2e-16 Alcohol dependence; BRCA cis rs7766436 0.614 rs2066335 chr6:22566590 C/T cg13666174 chr6:22585274 NA -0.41 -8.66 -0.32 3.86e-17 Coronary artery disease; BRCA trans rs9329221 0.716 rs11989640 chr8:10256054 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -9.21 -0.34 4.77e-19 Neuroticism; BRCA cis rs3772130 0.564 rs28620947 chr3:121585631 G/A cg20356878 chr3:121714668 ILDR1 0.43 9.9 0.36 1.41e-21 Cognitive performance; BRCA cis rs9443645 0.901 rs9361488 chr6:79782874 T/C cg11833968 chr6:79620685 NA -0.45 -10.0 -0.37 5.81e-22 Intelligence (multi-trait analysis); BRCA cis rs17253792 0.822 rs75991559 chr14:56092419 A/T cg24579896 chr14:56047964 C14orf33;KTN1 0.59 7.82 0.3 2.17e-14 Putamen volume; BRCA cis rs8072100 0.840 rs9912311 chr17:45547132 T/C cg25173405 chr17:45401733 C17orf57 -0.56 -12.07 -0.43 2.25e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.47 -0.32 1.66e-16 Total body bone mineral density; BRCA cis rs2304069 0.954 rs1962603 chr5:149393006 G/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.56 8.65 0.32 4.28e-17 HIV-1 control; BRCA cis rs2404602 1.000 rs12594541 chr15:76834368 G/A cg23625390 chr15:77176239 SCAPER 0.41 10.25 0.38 6.33e-23 Blood metabolite levels; BRCA cis rs6840258 1.000 rs7682652 chr4:87913444 C/T cg08197287 chr4:87952173 AFF1 -0.44 -8.63 -0.32 5.02e-17 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg19678392 chr7:94953810 PON1 -0.43 -8.98 -0.33 3.01e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4481887 0.893 rs4576683 chr1:248472390 T/C cg00666640 chr1:248458726 OR2T12 0.3 8.39 0.31 3.15e-16 Common traits (Other); BRCA cis rs780094 0.606 rs6729709 chr2:27583156 G/A cg22903471 chr2:27725779 GCKR -0.32 -7.85 -0.3 1.77e-14 Calcium levels;Fasting blood insulin;Metabolic traits;Triglyceride levels;Fasting plasma glucose;Urate levels in overweight individuals;Urate levels in obese individuals;Uric acid levels;Height;Age-related diseases, mortality and associated endophenotypes;Renal underexcretion gout;Fasting blood glucose (BMI interaction);Urate levels;Gondoic acid (20:1n-9) levels;Fasting blood insulin (BMI interaction);Triglycerides;Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid);Type 2 diabetes;Nonalcoholic fatty liver disease;Hypertriglyceridemia;C-reactive protein;Age-related disease endophenotypes;LDL cholesterol;Metabolic syndrome;Crohn's disease;Alcohol consumption (drinks per week);Homeostasis model assessment of insulin resistance;Alcohol consumption;Red blood cell count;Fasting blood glucose; BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.26 -0.49 3e-40 Platelet count; BRCA cis rs12791968 0.765 rs12790121 chr11:45001089 G/A cg11846598 chr11:44996168 LOC221122 -0.48 -8.67 -0.32 3.63e-17 Inhibitory control; BRCA cis rs3857067 0.806 rs10212784 chr4:95101638 C/T cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.34 -0.35 1.56e-19 QT interval; BRCA cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg06026331 chr20:60912101 LAMA5 -0.41 -8.32 -0.31 5.23e-16 Colorectal cancer; BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg24082983 chr21:31802169 KRTAP13-4 0.32 8.18 0.31 1.58e-15 HDL cholesterol; BRCA cis rs7617773 0.780 rs11720026 chr3:48377921 T/C cg11946769 chr3:48343235 NME6 0.66 13.21 0.46 2.22e-35 Coronary artery disease; BRCA cis rs2180341 0.694 rs2875972 chr6:127585522 T/C cg24812749 chr6:127587940 RNF146 0.75 16.48 0.55 3.9e-51 Breast cancer; BRCA cis rs10751667 0.666 rs7950967 chr11:955638 G/A cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA cis rs7020830 0.931 rs13297576 chr9:37142189 A/C cg14294708 chr9:37120828 ZCCHC7 1.18 42.39 0.86 7.85e-188 Schizophrenia; BRCA cis rs7586879 0.789 rs67221599 chr2:25131948 T/C cg01884057 chr2:25150051 NA 0.31 7.86 0.3 1.62e-14 Body mass index; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.75 16.78 0.55 1.29e-52 Lymphocyte counts; BRCA cis rs7811142 0.830 rs11769057 chr7:99964661 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.53 0.61 5.76e-67 Platelet count; BRCA cis rs12477438 0.798 rs1349778 chr2:99645011 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.35 -0.49 1.13e-40 Chronic sinus infection; BRCA cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.1e-14 Developmental language disorder (linguistic errors); BRCA cis rs6964587 1.000 rs3753109 chr7:91630001 G/C cg01689657 chr7:91764605 CYP51A1 0.21 7.86 0.3 1.6e-14 Breast cancer; BRCA cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg15448220 chr1:150897856 SETDB1 0.35 7.84 0.3 1.89e-14 Melanoma; BRCA cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg13877915 chr19:58951672 ZNF132 0.39 9.34 0.35 1.61e-19 Uric acid clearance; BRCA cis rs10504229 0.906 rs7006539 chr8:58178799 A/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.53 -0.47 7.65e-37 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg00149659 chr3:10157352 C3orf10 1.03 17.36 0.57 1.41e-55 Alzheimer's disease; BRCA cis rs853679 0.517 rs56310871 chr6:28044482 A/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.13 -0.31 2.26e-15 Depression; BRCA cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg04727924 chr7:799746 HEATR2 -0.54 -9.47 -0.35 5.45e-20 Cerebrospinal P-tau181p levels; BRCA cis rs11690935 0.959 rs12692974 chr2:172663256 T/C cg13550731 chr2:172543902 DYNC1I2 -0.88 -28.7 -0.75 4.96e-117 Schizophrenia; BRCA cis rs875971 0.545 rs73376401 chr7:65639828 G/A cg11764359 chr7:65958608 NA 0.66 11.98 0.43 5.68e-30 Aortic root size; BRCA cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA trans rs2727020 0.612 rs603672 chr11:49234566 T/A cg00717180 chr2:96193071 NA 0.3 8.35 0.31 4.36e-16 Coronary artery disease; BRCA cis rs881375 0.933 rs10818485 chr9:123667816 G/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.5 0.32 1.31e-16 Rheumatoid arthritis; BRCA cis rs2882667 0.858 rs11744972 chr5:138428789 A/G cg04439458 chr5:138467593 SIL1 -0.37 -9.77 -0.36 4.16e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2070488 0.775 rs4371464 chr3:38548021 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.59 -15.44 -0.52 6.06e-46 Electrocardiographic conduction measures; BRCA trans rs11165623 0.602 rs7521690 chr1:97015761 A/C cg10631902 chr5:14652156 NA -0.43 -12.23 -0.44 4.54e-31 Hip circumference;Waist circumference; BRCA cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg04267008 chr7:1944627 MAD1L1 -0.53 -11.48 -0.41 7.28e-28 Bipolar disorder and schizophrenia; BRCA cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg06064525 chr11:970664 AP2A2 -0.48 -15.89 -0.53 3.6e-48 Alzheimer's disease (late onset); BRCA trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -10.91 -0.4 1.62e-25 Retinal vascular caliber; BRCA cis rs1904096 0.506 rs8336 chr4:95211610 A/G cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.06 -0.37 3.44e-22 Type 2 diabetes; BRCA cis rs7903847 0.619 rs9888116 chr10:99159482 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.86 -0.33 7.98e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs12188164 0.582 rs80273890 chr5:483057 C/T cg15640734 chr5:494837 SLC9A3 -0.42 -8.1 -0.31 2.75e-15 Cystic fibrosis severity; BRCA cis rs7707921 0.767 rs178931 chr5:81575601 T/A cg15871215 chr5:81402204 ATG10 0.36 8.21 0.31 1.26e-15 Breast cancer; BRCA cis rs7072216 0.727 rs7915108 chr10:100164441 T/C cg26618903 chr10:100175079 PYROXD2 -0.31 -8.67 -0.32 3.68e-17 Metabolite levels; BRCA cis rs9393777 0.513 rs34388707 chr6:27050396 A/G cg12292205 chr6:26970375 C6orf41 -0.63 -9.87 -0.36 1.71e-21 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.620 rs2504566 chr6:26660488 G/C cg11502198 chr6:26597334 ABT1 0.56 11.97 0.43 6.47e-30 Intelligence (multi-trait analysis); BRCA trans rs3733585 0.673 rs7377578 chr4:9952775 T/C cg26043149 chr18:55253948 FECH -0.37 -8.13 -0.31 2.18e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6088580 0.634 rs6088483 chr20:32984714 T/A cg08999081 chr20:33150536 PIGU -0.46 -12.81 -0.45 1.27e-33 Glomerular filtration rate (creatinine); BRCA cis rs3820928 0.934 rs66959645 chr2:227761582 C/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.76 -0.33 1.78e-17 Pulmonary function; BRCA cis rs4665809 0.590 rs13387855 chr2:26420708 T/G cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.32 -0.68 1.6e-87 Gut microbiome composition (summer); BRCA cis rs9379850 0.730 rs9393738 chr6:26620658 G/A cg12826209 chr6:26865740 GUSBL1 0.59 10.4 0.38 1.65e-23 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.542 rs4440510 chr6:8471818 C/T cg23788917 chr6:8435910 SLC35B3 0.47 10.31 0.38 3.56e-23 Motion sickness; BRCA cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.17 0.74 4.21e-114 Chronic sinus infection; BRCA cis rs2505998 0.719 rs10900296 chr10:43572507 A/G cg15436174 chr10:43711423 RASGEF1A -0.39 -7.82 -0.3 2.2e-14 Hirschsprung disease; BRCA cis rs6089584 0.816 rs744778 chr20:60631365 A/G cg13770153 chr20:60521292 NA -0.43 -9.64 -0.36 1.32e-20 Body mass index; BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 7.93 0.3 9.75e-15 Tonsillectomy; BRCA cis rs4665809 0.590 rs2033317 chr2:26477650 G/A cg26119090 chr2:26468346 HADHA;HADHB 1.0 21.9 0.65 9.17e-80 Gut microbiome composition (summer); BRCA cis rs2204008 0.777 rs2049130 chr12:38444837 G/A cg26384229 chr12:38710491 ALG10B 0.64 14.93 0.51 1.8e-43 Bladder cancer; BRCA trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg03929089 chr4:120376271 NA -0.71 -13.98 -0.48 6.06e-39 Coronary artery disease; BRCA cis rs2742234 0.503 rs1254968 chr10:43691691 C/T cg15436174 chr10:43711423 RASGEF1A 0.55 11.33 0.41 3.14e-27 Hirschsprung disease; BRCA cis rs2115536 1.000 rs11072871 chr15:80197931 T/C cg00225070 chr15:80189496 MTHFS 0.41 9.85 0.36 2.13e-21 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs651907 1.000 rs665211 chr3:101600028 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.32 8.25 0.31 8.97e-16 Colorectal cancer; BRCA cis rs6878727 0.707 rs7737676 chr5:123718822 T/A cg01806427 chr5:123737813 NA 0.39 9.04 0.34 1.85e-18 Breast cancer; BRCA cis rs10911251 0.546 rs2027081 chr1:183074576 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.73 0.57 1.73e-57 Colorectal cancer; BRCA cis rs7618915 0.547 rs11714419 chr3:52628816 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.15 -0.31 1.92e-15 Bipolar disorder; BRCA cis rs11190604 1.000 rs2495739 chr10:102335507 C/T cg07080220 chr10:102295463 HIF1AN 0.55 12.21 0.43 5.97e-31 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4819052 0.808 rs11909411 chr21:46676556 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.05 0.46 1.08e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2032447 0.898 rs807205 chr6:26075035 C/G cg03264133 chr6:25882463 NA -0.5 -10.38 -0.38 2e-23 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.863 rs3822191 chr4:120428101 A/T cg09307838 chr4:120376055 NA 0.69 13.72 0.48 1.03e-37 Corneal astigmatism; BRCA cis rs3768617 0.565 rs7542277 chr1:183063527 C/T ch.1.3577855R chr1:183094577 LAMC1 0.63 16.11 0.54 2.88e-49 Fuchs's corneal dystrophy; BRCA cis rs9469890 0.604 rs11756281 chr6:34503446 T/C cg17674042 chr6:34482479 PACSIN1 -0.33 -8.56 -0.32 8.1e-17 Pubertal anthropometrics;Coronary artery disease; BRCA trans rs783540 0.900 rs4778686 chr15:83310835 C/T cg18393722 chr15:85113863 UBE2QP1 -0.28 -8.66 -0.32 3.93e-17 Schizophrenia; BRCA cis rs6089584 0.526 rs6089316 chr20:60627552 C/T cg06108461 chr20:60628389 TAF4 -0.73 -15.3 -0.52 3e-45 Body mass index; BRCA cis rs9733 0.650 rs6698495 chr1:150564476 T/C cg18016565 chr1:150552671 MCL1 -0.45 -10.22 -0.37 7.86e-23 Tonsillectomy; BRCA cis rs4319547 0.656 rs10773088 chr12:122828069 A/T cg05707623 chr12:122985044 ZCCHC8 -0.49 -9.54 -0.35 2.87e-20 Body mass index; BRCA cis rs7953508 0.506 rs3782415 chr12:93967755 T/C cg18151635 chr12:93972918 NA -0.46 -9.27 -0.34 2.83e-19 Pubertal anthropometrics; BRCA cis rs281408 0.559 rs281386 chr19:49217305 A/G cg13540341 chr19:49222985 MAMSTR 0.39 9.98 0.37 6.62e-22 Urinary metabolites (H-NMR features); BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.26 0.34 3.13e-19 Tonsillectomy; BRCA cis rs7615952 0.576 rs2276726 chr3:125826287 C/G cg15145296 chr3:125709740 NA -0.53 -9.12 -0.34 9.41e-19 Blood pressure (smoking interaction); BRCA cis rs9473147 0.516 rs9296564 chr6:47494759 A/G cg12968598 chr6:47444699 CD2AP 0.44 9.68 0.36 8.85e-21 Platelet distribution width;Mean platelet volume; BRCA trans rs3733585 0.605 rs4697708 chr4:10121189 A/G cg26043149 chr18:55253948 FECH -0.4 -8.62 -0.32 5.38e-17 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg02951883 chr7:2050386 MAD1L1 -0.6 -15.13 -0.51 2.09e-44 Bipolar disorder and schizophrenia; BRCA cis rs2762353 0.808 rs1165183 chr6:25836380 A/G cg12310025 chr6:25882481 NA -0.54 -13.09 -0.46 7.43e-35 Blood metabolite levels; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.54 8.48 0.32 1.55e-16 Renal function-related traits (BUN); BRCA cis rs780096 0.506 rs780100 chr2:27652153 G/T cg12000995 chr2:27665139 KRTCAP3 -0.35 -8.97 -0.33 3.23e-18 Total body bone mineral density; BRCA cis rs911555 0.755 rs17841064 chr14:103900609 A/G cg12935359 chr14:103987150 CKB -0.64 -14.93 -0.51 1.86e-43 Intelligence (multi-trait analysis); BRCA cis rs317689 0.718 rs315130 chr12:69761444 T/C cg20891283 chr12:69753455 YEATS4 0.56 11.45 0.41 9.77e-28 Response to diuretic therapy; BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg16606324 chr3:10149918 C3orf24 0.51 9.99 0.37 6.1e-22 Alzheimer's disease; BRCA cis rs17401966 0.898 rs11582123 chr1:10303942 A/T cg19773385 chr1:10388646 KIF1B -0.36 -7.97 -0.3 7.53e-15 Hepatocellular carcinoma; BRCA cis rs7666738 0.830 rs6848397 chr4:98946738 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs67340775 0.834 rs13218875 chr6:27884012 C/T cg06606381 chr12:133084897 FBRSL1 -0.89 -8.98 -0.33 2.9e-18 Lung cancer in ever smokers; BRCA cis rs2749592 0.918 rs11011388 chr10:38155210 C/T cg25427524 chr10:38739819 LOC399744 0.59 11.32 0.41 3.36e-27 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4727027 0.870 rs62507509 chr7:148795522 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.65 0.39 1.79e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4363385 0.818 rs10788854 chr1:153002320 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.06 -0.34 1.62e-18 Inflammatory skin disease; BRCA cis rs7020830 0.898 rs13284651 chr9:37222681 G/T cg14294708 chr9:37120828 ZCCHC7 -1.08 -33.02 -0.79 2.84e-140 Schizophrenia; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.57 -11.5 -0.41 5.93e-28 Lymphocyte counts; BRCA cis rs6754311 0.551 rs6739713 chr2:136488978 A/G cg07169764 chr2:136633963 MCM6 0.49 8.94 0.33 4.01e-18 Mosquito bite size; BRCA cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs57994353 0.861 rs3812591 chr9:139341612 C/T cg14019695 chr9:139328340 INPP5E -0.43 -9.15 -0.34 7.83e-19 Eosinophil counts;Cutaneous squamous cell carcinoma; BRCA cis rs60871478 1.000 rs67721251 chr7:825114 T/C cg27478167 chr7:817139 HEATR2 -0.42 -9.13 -0.34 9.23e-19 Cerebrospinal P-tau181p levels; BRCA cis rs12586317 0.620 rs12588810 chr14:35554484 C/T cg05294307 chr14:35346193 BAZ1A -0.62 -10.53 -0.38 4.88e-24 Psoriasis; BRCA cis rs6750047 0.625 rs59363818 chr2:38261973 A/C cg07380506 chr2:38303506 CYP1B1 -0.49 -10.61 -0.39 2.39e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs4665809 1.000 rs4665304 chr2:26313406 C/T cg22920501 chr2:26401640 FAM59B -0.66 -11.6 -0.42 2.35e-28 Gut microbiome composition (summer); BRCA cis rs1552244 0.572 rs3774208 chr3:10164722 T/G cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs6456156 0.565 rs12525345 chr6:167478875 T/C cg07741184 chr6:167504864 NA 0.33 9.82 0.36 2.75e-21 Primary biliary cholangitis; BRCA cis rs12549902 0.800 rs7825337 chr8:41507237 C/T cg21772509 chr8:41503840 NKX6-3 0.44 10.39 0.38 1.88e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs9399135 0.967 rs7741626 chr6:135314182 C/T cg24558204 chr6:135376177 HBS1L 0.45 12.42 0.44 7.31e-32 Red blood cell count; BRCA cis rs7903847 0.642 rs10882908 chr10:99134970 T/C cg08345082 chr10:99160200 RRP12 -0.29 -8.6 -0.32 6.17e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg03354898 chr7:1950403 MAD1L1 0.38 8.2 0.31 1.35e-15 Schizophrenia; BRCA cis rs35306767 0.715 rs11253550 chr10:1028288 C/G cg10556349 chr10:835070 NA 0.63 8.66 0.32 3.75e-17 Eosinophil percentage of granulocytes; BRCA cis rs2075371 0.897 rs1646733 chr7:134002228 C/A cg11752832 chr7:134001865 SLC35B4 0.53 13.73 0.48 8.72e-38 Mean platelet volume; BRCA cis rs10791323 0.569 rs5019134 chr11:133713082 G/C cg06766960 chr11:133703094 NA -0.63 -13.39 -0.47 3.35e-36 Childhood ear infection; BRCA cis rs910316 0.763 rs175435 chr14:75612025 A/G cg08847533 chr14:75593920 NEK9 0.77 18.07 0.58 2.75e-59 Height; BRCA cis rs9814567 0.964 rs9815894 chr3:134282796 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2625529 0.730 rs2957737 chr15:72265410 A/G cg16672083 chr15:72433130 SENP8 0.72 16.86 0.55 4.94e-53 Red blood cell count; BRCA trans rs1459104 1.000 rs12577374 chr11:55216921 A/T cg15704280 chr7:45808275 SEPT13 0.65 8.15 0.31 1.85e-15 Body mass index; BRCA cis rs1707322 0.721 rs28817701 chr1:46186050 C/T cg03146154 chr1:46216737 IPP 0.54 12.02 0.43 3.92e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs72781680 1.000 rs72781643 chr2:24208746 G/A cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs7589728 1.000 rs12473740 chr2:88527647 A/G cg04511125 chr2:88470314 THNSL2 0.79 11.47 0.41 8.16e-28 Plasma clusterin levels; BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.83 -0.51 5.63e-43 Initial pursuit acceleration; BRCA cis rs10751667 0.666 rs7395823 chr11:942701 T/C cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs7647973 0.710 rs6797299 chr3:49609794 G/T cg03060546 chr3:49711283 APEH 0.6 9.83 0.36 2.5e-21 Menarche (age at onset); BRCA cis rs1707322 1.000 rs34446427 chr1:46417655 A/C cg03146154 chr1:46216737 IPP 0.45 10.01 0.37 5.27e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg08859206 chr1:53392774 SCP2 -0.52 -11.34 -0.41 2.72e-27 Monocyte count; BRCA cis rs4363385 0.818 rs4452994 chr1:152986871 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.41 -0.32 2.64e-16 Inflammatory skin disease; BRCA cis rs13046373 0.508 rs13048637 chr21:31999055 T/G cg22337977 chr21:31811175 KRTAP15-1 0.33 8.0 0.3 5.71e-15 HDL cholesterol; BRCA cis rs6066825 0.644 rs6019386 chr20:47326440 T/G cg18078177 chr20:47281410 PREX1 0.4 10.06 0.37 3.39e-22 Colorectal cancer; BRCA cis rs698833 0.509 rs1946932 chr2:44543125 C/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 7.97 0.3 7.31e-15 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs10504229 0.724 rs58715581 chr8:58134568 A/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs10028773 0.515 rs9994488 chr4:120587781 C/T cg09307838 chr4:120376055 NA 0.52 10.67 0.39 1.49e-24 Educational attainment; BRCA cis rs495337 1.000 rs495337 chr20:48522330 G/A cg17835207 chr20:48524531 SPATA2 -0.57 -12.89 -0.45 5.73e-34 Psoriasis; BRCA cis rs6700896 0.864 rs11208718 chr1:66158995 G/A cg04111102 chr1:66153794 NA 0.34 8.5 0.32 1.3e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs514406 0.825 rs7523761 chr1:53250915 T/C cg27535305 chr1:53392650 SCP2 0.33 8.11 0.31 2.53e-15 Monocyte count; BRCA cis rs8072100 0.935 rs12150231 chr17:45717091 G/A cg25173405 chr17:45401733 C17orf57 0.52 11.12 0.4 2.15e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7851660 0.967 rs12348304 chr9:100611233 T/C cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.81e-17 Strep throat; BRCA cis rs6089829 0.962 rs4997812 chr20:61663153 T/G cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7833790 0.926 rs72686467 chr8:82758929 T/G cg17211192 chr8:82754475 SNX16 0.64 12.03 0.43 3.56e-30 Diastolic blood pressure; BRCA cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg13319975 chr6:146136371 FBXO30 -0.4 -8.95 -0.33 3.7e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs2032447 0.839 rs199751 chr6:26015583 T/C cg18357526 chr6:26021779 HIST1H4A 0.5 8.99 0.34 2.69e-18 Intelligence (multi-trait analysis); BRCA cis rs7100689 0.577 rs10749550 chr10:82031197 A/G cg01528321 chr10:82214614 TSPAN14 0.83 18.2 0.58 6.31e-60 Post bronchodilator FEV1; BRCA cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11644478 chr21:40555479 PSMG1 0.84 19.05 0.6 1.94e-64 Cognitive function; BRCA cis rs1707322 1.000 rs10890380 chr1:46449469 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.73 0.39 8.12e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6446731 0.636 rs2157091 chr4:3273099 G/A cg08886695 chr4:3369023 RGS12 -0.37 -9.7 -0.36 7.62e-21 Mean platelet volume; BRCA cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg20203395 chr5:56204925 C5orf35 -0.43 -9.62 -0.36 1.45e-20 Initial pursuit acceleration; BRCA trans rs7248779 0.512 rs12610522 chr19:2413228 C/T cg25835954 chr13:50160062 RCBTB1 0.44 8.66 0.32 3.74e-17 Cortisol levels (saliva); BRCA cis rs769267 0.792 rs4808961 chr19:19577215 C/G cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.97 0.33 3.23e-18 Tonsillectomy; BRCA cis rs1577917 0.958 rs11756615 chr6:86679835 G/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -13.41 -0.47 2.55e-36 Response to antipsychotic treatment; BRCA cis rs6582630 0.519 rs11519914 chr12:38287014 A/G cg26384229 chr12:38710491 ALG10B 0.65 15.55 0.52 1.7e-46 Drug-induced liver injury (flucloxacillin); BRCA cis rs4588572 0.643 rs1560197 chr5:77768302 T/C cg11547950 chr5:77652471 NA -0.49 -8.64 -0.32 4.55e-17 Triglycerides; BRCA cis rs2243480 1.000 rs316334 chr7:65602126 G/T cg18252515 chr7:66147081 NA -1.06 -15.58 -0.52 1.26e-46 Diabetic kidney disease; BRCA cis rs28830936 0.528 rs11630242 chr15:42124643 T/C cg17847044 chr15:42102381 MAPKBP1 -0.45 -16.57 -0.55 1.52e-51 Diastolic blood pressure; BRCA cis rs6964587 0.773 rs13223564 chr7:91932666 A/G cg17063962 chr7:91808500 NA 0.51 11.01 0.4 6.31e-26 Breast cancer; BRCA cis rs13046373 0.508 rs13048637 chr21:31999055 T/G cg16812893 chr21:31813075 KRTAP15-1 0.37 9.34 0.35 1.62e-19 HDL cholesterol; BRCA cis rs939658 0.805 rs35832166 chr15:79417994 G/T cg17916960 chr15:79447300 NA -0.45 -11.05 -0.4 4.22e-26 Refractive error; BRCA cis rs875971 1.000 rs1981798 chr7:65954903 G/T cg12463550 chr7:65579703 CRCP 0.37 7.92 0.3 1.03e-14 Aortic root size; BRCA cis rs10056811 0.538 rs3923323 chr5:74372141 C/T cg19683494 chr5:74908142 NA -0.55 -8.53 -0.32 1.03e-16 Coronary artery disease; BRCA cis rs6952808 1.000 rs6954673 chr7:1886937 C/T cg22963979 chr7:1858916 MAD1L1 -0.45 -9.06 -0.34 1.51e-18 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.906 rs112793785 chr8:58190537 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.51 -0.47 9.38e-37 Developmental language disorder (linguistic errors); BRCA cis rs4664304 0.658 rs2667015 chr2:160868586 T/C cg14819504 chr2:160761413 LY75 -0.33 -8.14 -0.31 2.13e-15 Crohn's disease;Inflammatory bowel disease; BRCA cis rs1712517 1.000 rs1163084 chr10:105039048 T/C cg05636881 chr10:105038444 INA 0.36 8.35 0.31 4.15e-16 Migraine; BRCA cis rs1949733 1.000 rs3103067 chr4:8511223 A/G cg11789530 chr4:8429930 ACOX3 0.62 15.84 0.53 6.63e-48 Response to antineoplastic agents; BRCA cis rs6089584 0.508 rs6061988 chr20:60626300 C/T cg13770153 chr20:60521292 NA -0.4 -9.47 -0.35 5.12e-20 Body mass index; BRCA cis rs4845875 0.626 rs11121827 chr1:11832100 T/A cg24844545 chr1:11908347 NPPA 0.31 7.85 0.3 1.78e-14 Midregional pro atrial natriuretic peptide levels; BRCA cis rs7264396 1.000 rs224440 chr20:34159447 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.49 -10.68 -0.39 1.3e-24 Total cholesterol levels; BRCA cis rs11252926 0.537 rs4554800 chr10:458477 G/T cg16386425 chr10:429943 DIP2C 0.42 9.04 0.34 1.88e-18 Psychosis in Alzheimer's disease; BRCA cis rs60871478 1.000 rs60871478 chr7:827325 A/G cg04727924 chr7:799746 HEATR2 -0.58 -11.35 -0.41 2.56e-27 Cerebrospinal P-tau181p levels; BRCA cis rs2032447 0.520 rs198818 chr6:26125711 A/C cg03264133 chr6:25882463 NA 0.41 8.76 0.33 1.79e-17 Intelligence (multi-trait analysis); BRCA cis rs67478160 0.619 rs1040813 chr14:104306696 T/C cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.94 -0.4 1.14e-25 Schizophrenia; BRCA trans rs17685 0.712 rs1859794 chr7:75821544 G/A cg19862616 chr7:65841803 NCRNA00174 0.79 24.67 0.7 6.38e-95 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7847628 0.587 rs3793638 chr9:123582697 G/T cg14255062 chr9:123606675 PSMD5;LOC253039 0.3 8.18 0.31 1.53e-15 Birth weight; BRCA cis rs7301016 0.901 rs12369961 chr12:62966584 C/T cg11441379 chr12:63026424 NA 0.46 8.69 0.32 3.13e-17 IgG glycosylation; BRCA cis rs6882046 0.513 rs681446 chr5:88054292 C/T cg22951263 chr5:87985283 NA 0.39 11.18 0.4 1.21e-26 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs6879260 1.000 rs7706951 chr5:179733407 C/T cg02891314 chr5:179741120 GFPT2 -0.66 -13.28 -0.47 9.96e-36 Height; BRCA cis rs208520 0.690 rs207740 chr6:66764132 T/G cg07460842 chr6:66804631 NA 1.0 20.0 0.62 1.76e-69 Exhaled nitric oxide output; BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 16.89 0.56 3.36e-53 Alzheimer's disease; BRCA cis rs9649465 1.000 rs6466881 chr7:123337734 G/C cg04330084 chr7:123175371 IQUB -0.3 -8.32 -0.31 5.51e-16 Migraine; BRCA cis rs490234 0.812 rs4838285 chr9:128446888 C/T cg14078157 chr9:128172775 NA -0.34 -8.05 -0.3 4.03e-15 Mean arterial pressure; BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg11814155 chr7:99998594 ZCWPW1 0.56 9.51 0.35 3.79e-20 Platelet count; BRCA trans rs9858542 0.953 rs11713474 chr3:49611457 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.62 -0.36 1.46e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs17253792 0.822 rs76819679 chr14:56134672 C/G cg01858014 chr14:56050164 KTN1 -0.74 -9.16 -0.34 7.09e-19 Putamen volume; BRCA cis rs9837602 0.745 rs9816538 chr3:99907924 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.51 8.18 0.31 1.58e-15 Breast cancer; BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.88 0.33 6.89e-18 Tonsillectomy; BRCA cis rs2742234 0.590 rs1254965 chr10:43689853 C/T cg15436174 chr10:43711423 RASGEF1A 0.55 11.25 0.41 6.37e-27 Hirschsprung disease; BRCA cis rs4722166 1.000 rs4722166 chr7:22738762 G/T cg26061582 chr7:22766209 IL6 0.39 7.92 0.3 1.04e-14 Lung cancer; BRCA cis rs10751667 0.643 rs10751669 chr11:942344 C/G cg06064525 chr11:970664 AP2A2 0.49 16.35 0.54 1.82e-50 Alzheimer's disease (late onset); BRCA cis rs35661897 0.920 rs12476220 chr2:227312391 A/C cg03426602 chr2:227312417 NA 0.53 8.76 0.33 1.73e-17 Urinary tract infection frequency; BRCA cis rs7267979 1.000 rs2258135 chr20:25272323 C/A cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.683 rs11784908 chr8:58131472 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs858239 0.539 rs2141305 chr7:23191899 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.94 0.4 1.21e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.41 0.35 8.9e-20 Tonsillectomy; BRCA cis rs7095944 0.583 rs12218394 chr10:126480591 G/C cg08799069 chr10:126477246 METTL10 -0.39 -9.32 -0.35 1.89e-19 Asthma; BRCA cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 13.82 0.48 3.31e-38 Eosinophil percentage of white cells; BRCA cis rs7772486 0.790 rs2254257 chr6:146203724 C/T cg23711669 chr6:146136114 FBXO30 0.77 17.89 0.58 2.48e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs1020064 0.636 rs2576726 chr2:105936412 A/G cg02079111 chr2:105885981 TGFBRAP1 0.42 8.2 0.31 1.3e-15 AIDS; BRCA cis rs858239 0.600 rs2072369 chr7:23146189 A/G cg23682824 chr7:23144976 KLHL7 0.45 12.18 0.43 7.48e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs2404602 0.647 rs12903586 chr15:77168240 G/A cg23625390 chr15:77176239 SCAPER -0.54 -13.89 -0.48 1.67e-38 Blood metabolite levels; BRCA trans rs800082 0.671 rs800099 chr3:144398547 A/T cg24215973 chr2:240111563 HDAC4 -0.64 -14.59 -0.5 8.35e-42 Smoking behavior; BRCA cis rs758324 0.947 rs2133707 chr5:131181280 C/T cg06307176 chr5:131281290 NA 0.52 10.09 0.37 2.49e-22 Alzheimer's disease in APOE e4- carriers; BRCA cis rs11146838 1 rs11146838 chr10:39149977 A/T cg00409905 chr10:38381863 ZNF37A -0.47 -9.82 -0.36 2.81e-21 Breast cancer; BRCA cis rs9311474 0.607 rs4475032 chr3:52560021 C/T cg10802521 chr3:52805072 NEK4 -0.3 -7.82 -0.3 2.16e-14 Electroencephalogram traits; BRCA cis rs4074536 0.574 rs10801970 chr1:116287651 G/A cg21648376 chr1:116311395 CASQ2 -0.48 -8.43 -0.32 2.24e-16 QRS duration; BRCA cis rs7098414 0.511 rs10788603 chr10:82148137 G/T cg01528321 chr10:82214614 TSPAN14 0.64 13.63 0.47 2.58e-37 Post bronchodilator FEV1; BRCA cis rs7647973 1.000 rs11710434 chr3:49346130 T/C cg07636037 chr3:49044803 WDR6 0.7 14.99 0.51 9.83e-44 Menarche (age at onset); BRCA cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26378065 chr17:18585709 ZNF286B 0.43 9.12 0.34 9.28e-19 Educational attainment (years of education); BRCA cis rs344364 0.511 rs62040571 chr16:1948514 C/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA trans rs11098499 0.863 rs11933966 chr4:120476715 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.53 0.32 1.05e-16 Corneal astigmatism; BRCA cis rs6088580 0.505 rs6142219 chr20:33256345 G/A cg08999081 chr20:33150536 PIGU -0.34 -8.8 -0.33 1.26e-17 Glomerular filtration rate (creatinine); BRCA trans rs6089829 0.889 rs6090206 chr20:61668363 G/A cg17470723 chr8:74884337 TCEB1 0.4 8.64 0.32 4.64e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs4268898 0.552 rs6754391 chr2:24369019 C/T cg06627628 chr2:24431161 ITSN2 -0.41 -8.53 -0.32 1.04e-16 Asthma; BRCA cis rs12497850 0.931 rs4072859 chr3:49032205 G/C cg06212747 chr3:49208901 KLHDC8B 0.46 9.25 0.34 3.19e-19 Parkinson's disease; BRCA cis rs4803455 0.586 rs4803457 chr19:41861359 T/C cg08477640 chr19:41863820 B9D2 0.38 7.92 0.3 1.09e-14 Migraine;Coronary artery disease; BRCA cis rs938554 0.577 rs7683856 chr4:10000947 A/G cg00071950 chr4:10020882 SLC2A9 0.42 7.9 0.3 1.26e-14 Blood metabolite levels; BRCA cis rs67460515 0.563 rs9876142 chr3:160780968 A/G cg03342759 chr3:160939853 NMD3 0.66 12.92 0.46 4.26e-34 Parkinson's disease; BRCA cis rs7474896 0.537 rs2749586 chr10:38270214 G/C cg25427524 chr10:38739819 LOC399744 0.52 9.61 0.36 1.58e-20 Obesity (extreme); BRCA cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg26061582 chr7:22766209 IL6 0.34 7.95 0.3 8.54e-15 Lung cancer; BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg00814883 chr7:100076585 TSC22D4 -0.49 -10.05 -0.37 3.65e-22 Platelet count; BRCA cis rs2580764 0.566 rs2972075 chr2:55292322 T/G cg09592903 chr2:55203963 RTN4 0.36 9.25 0.34 3.25e-19 Mean platelet volume; BRCA cis rs798554 0.757 rs2533878 chr7:2878707 A/G cg13628971 chr7:2884303 GNA12 -0.49 -10.01 -0.37 5.25e-22 Height; BRCA cis rs561341 1.000 rs576985 chr17:30323323 C/T cg00745463 chr17:30367425 LRRC37B -0.54 -8.89 -0.33 6.17e-18 Hip circumference adjusted for BMI; BRCA cis rs2066819 1.000 rs59626664 chr12:56636975 C/G cg26714650 chr12:56694279 CS -1.18 -15.33 -0.52 2.13e-45 Psoriasis vulgaris; BRCA cis rs6977660 0.714 rs10260866 chr7:19793151 T/C cg07541023 chr7:19748670 TWISTNB 0.65 10.86 0.39 2.52e-25 Thyroid stimulating hormone; BRCA cis rs8032158 0.963 rs1912402 chr15:56161919 C/T cg02198044 chr15:56286336 NEDD4 -0.37 -8.93 -0.33 4.47e-18 Keloid; BRCA cis rs4975709 0.569 rs4975743 chr5:1859941 G/T cg01114163 chr5:1856713 NA -0.35 -7.89 -0.3 1.29e-14 Cardiovascular disease risk factors; BRCA cis rs2243480 1.000 rs313799 chr7:65494330 A/G cg18252515 chr7:66147081 NA -0.85 -12.36 -0.44 1.23e-31 Diabetic kidney disease; BRCA cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.17 0.31 1.67e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6089584 1.000 rs6089591 chr20:60570548 A/C cg13770153 chr20:60521292 NA -0.45 -10.75 -0.39 7.07e-25 Body mass index; BRCA cis rs796364 0.664 rs3106089 chr2:200884615 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.23 0.41 7.85e-27 Schizophrenia; BRCA cis rs12618769 0.597 rs2278212 chr2:99136266 T/C cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA cis rs16958440 1.000 rs62096466 chr18:44636171 T/G cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.33e-21 Sitting height ratio; BRCA cis rs801193 0.569 rs11772819 chr7:66217970 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.89 0.3 1.31e-14 Aortic root size; BRCA trans rs11764590 0.756 rs17132130 chr7:2108036 G/C cg11693508 chr17:37793320 STARD3 0.39 8.14 0.31 2.09e-15 Neuroticism; BRCA trans rs7819412 0.522 rs10088853 chr8:10987967 G/A cg06636001 chr8:8085503 FLJ10661 -0.46 -8.99 -0.34 2.81e-18 Triglycerides; BRCA cis rs7666738 0.830 rs62321587 chr4:98997958 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2842992 0.789 rs9365093 chr6:160175819 C/G cg11366901 chr6:160182831 ACAT2 0.79 15.3 0.52 3.03e-45 Age-related macular degeneration (geographic atrophy); BRCA cis rs250677 0.522 rs56309414 chr5:148376026 C/G cg18129178 chr5:148520854 ABLIM3 -0.55 -10.42 -0.38 1.4e-23 Breast cancer; BRCA cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2599510 0.744 rs2254106 chr2:32768797 G/A cg02381751 chr2:32503542 YIPF4 0.48 9.94 0.37 9.73e-22 Interleukin-18 levels; BRCA cis rs1580019 0.961 rs958217 chr7:32493417 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.77 16.95 0.56 1.74e-53 Cognitive ability; BRCA cis rs7927771 0.864 rs112060627 chr11:47426956 G/A cg18512352 chr11:47633146 NA -0.33 -8.0 -0.3 5.8e-15 Subjective well-being; BRCA cis rs6429082 0.510 rs2789369 chr1:235503515 A/G cg26050004 chr1:235667680 B3GALNT2 0.32 7.85 0.3 1.71e-14 Adiposity; BRCA cis rs1008375 0.931 rs7435102 chr4:17571480 C/G cg16339924 chr4:17578868 LAP3 0.66 16.52 0.55 2.48e-51 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1421811 0.532 rs17540044 chr5:32692238 C/G cg16267343 chr5:32710456 NPR3 -0.64 -12.52 -0.44 2.47e-32 Blood pressure; BRCA cis rs4665809 1.000 rs4665820 chr2:26309150 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.64 -11.94 -0.43 7.99e-30 Gut microbiome composition (summer); BRCA cis rs534126 0.736 rs10239488 chr7:142949599 C/G cg21852589 chr7:142981689 TMEM139 0.44 10.06 0.37 3.23e-22 Cancer; BRCA cis rs875971 1.000 rs4718307 chr7:65610988 A/G cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.46e-15 Aortic root size; BRCA cis rs1997103 0.954 rs9649780 chr7:55411741 A/C cg17469321 chr7:55412551 NA 0.51 9.68 0.36 8.77e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs77106637 0.932 rs74439784 chr11:72649396 A/T cg03713592 chr11:72463424 ARAP1 0.74 11.35 0.41 2.45e-27 Type 2 diabetes; BRCA cis rs12701220 0.553 rs13245507 chr7:1163694 C/T cg02733842 chr7:1102375 C7orf50 -0.71 -12.78 -0.45 1.85e-33 Bronchopulmonary dysplasia; BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg04013093 chr6:42928303 GNMT -0.28 -8.65 -0.32 4.31e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs30380 0.632 rs26496 chr5:96137882 A/G cg16492584 chr5:96139282 ERAP1 -0.47 -11.27 -0.41 5.16e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs2204008 0.743 rs11182052 chr12:38450421 T/C cg26384229 chr12:38710491 ALG10B 0.67 15.75 0.53 1.84e-47 Bladder cancer; BRCA cis rs826838 0.967 rs11183577 chr12:38781887 A/G cg13010199 chr12:38710504 ALG10B 0.55 12.16 0.43 9.04e-31 Heart rate; BRCA cis rs7085104 0.660 rs3781286 chr10:104595719 C/T cg04362960 chr10:104952993 NT5C2 0.4 9.67 0.36 9.97e-21 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs4363385 0.747 rs61811427 chr1:152968419 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -8.8 -0.33 1.23e-17 Inflammatory skin disease; BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg20007245 chr22:24372913 LOC391322 0.51 10.12 0.37 1.91e-22 Urinary 1,3-butadiene metabolite levels in smokers; BRCA trans rs61931739 0.513 rs4931760 chr12:33898361 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.66 0.36 1.08e-20 Morning vs. evening chronotype; BRCA trans rs208520 0.770 rs1342960 chr6:66883514 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.94 -18.36 -0.59 9.01e-61 Exhaled nitric oxide output; BRCA trans rs561341 0.941 rs8066156 chr17:30361629 A/G cg20587970 chr11:113659929 NA -0.85 -16.39 -0.54 1.14e-50 Hip circumference adjusted for BMI; BRCA cis rs561341 1.000 rs4795670 chr17:30244839 T/C cg13647721 chr17:30228624 UTP6 0.5 8.7 0.33 2.89e-17 Hip circumference adjusted for BMI; BRCA cis rs2836974 0.932 rs56306759 chr21:40608106 G/A cg11890956 chr21:40555474 PSMG1 1.07 30.18 0.77 4.67e-125 Cognitive function; BRCA cis rs7511006 1.000 rs7364173 chr22:50681029 C/T cg16473166 chr22:50639996 SELO -0.47 -10.66 -0.39 1.57e-24 Obesity-related traits; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg02592271 chr2:27665507 KRTCAP3 -0.33 -8.37 -0.31 3.65e-16 Total body bone mineral density; BRCA cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.2e-39 Lymphocyte counts; BRCA cis rs10504229 1.000 rs73609760 chr8:58192170 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -11.98 -0.43 5.89e-30 Developmental language disorder (linguistic errors); BRCA cis rs921968 0.541 rs7603816 chr2:219396255 C/T cg10223061 chr2:219282414 VIL1 0.3 8.77 0.33 1.61e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.15 -0.37 1.54e-22 Initial pursuit acceleration; BRCA cis rs10504229 1.000 rs60651159 chr8:58174074 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA trans rs877282 0.786 rs11253392 chr10:788768 G/A cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs2191566 0.576 rs381628 chr19:44494333 T/C cg20607764 chr19:44506953 ZNF230 0.37 7.98 0.3 6.74e-15 Acute lymphoblastic leukemia (childhood); BRCA cis rs9796 0.558 rs7166905 chr15:41514876 G/C cg18705301 chr15:41695430 NDUFAF1 -0.36 -7.85 -0.3 1.75e-14 Menopause (age at onset); BRCA cis rs6815814 0.950 rs5743794 chr4:38832727 C/T cg02016764 chr4:38805732 TLR1 -0.52 -8.09 -0.3 2.92e-15 Breast cancer; BRCA cis rs2180341 0.960 rs9401953 chr6:127687574 G/A cg24812749 chr6:127587940 RNF146 0.86 19.78 0.62 2.55e-68 Breast cancer; BRCA cis rs701145 0.585 rs959376 chr3:153866707 A/T cg12800244 chr3:153838788 SGEF 0.57 7.91 0.3 1.12e-14 Coronary artery disease; BRCA cis rs7631605 0.935 rs6550447 chr3:37078280 G/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.77 0.36 4.05e-21 Cerebrospinal P-tau181p levels; BRCA cis rs9633740 1.000 rs10748526 chr10:82273079 T/C cg01528321 chr10:82214614 TSPAN14 0.84 16.9 0.56 2.95e-53 Post bronchodilator FEV1; BRCA cis rs67478160 0.595 rs1475007 chr14:104297147 A/G cg26031613 chr14:104095156 KLC1 -0.44 -8.63 -0.32 4.79e-17 Schizophrenia; BRCA cis rs7555523 0.887 rs2814471 chr1:165739598 C/T cg24409356 chr1:165738333 TMCO1 0.5 8.28 0.31 6.99e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs936229 0.813 rs8033381 chr15:75080685 G/A cg10253484 chr15:75165896 SCAMP2 -0.52 -9.92 -0.37 1.1e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs11792861 0.555 rs4978767 chr9:111762925 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.58 12.58 0.45 1.41e-32 Menarche (age at onset); BRCA cis rs12579753 1.000 rs34031374 chr12:82235615 G/C cg07988820 chr12:82153109 PPFIA2 -0.64 -10.39 -0.38 1.86e-23 Resting heart rate; BRCA trans rs11098499 0.954 rs13113483 chr4:120309039 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs2153535 0.580 rs1932280 chr6:8473654 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.62 0.39 2.17e-24 Motion sickness; BRCA cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg18132916 chr6:79620363 NA -0.49 -11.06 -0.4 3.87e-26 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.517 rs1843738 chr12:34056935 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.57 0.35 2.29e-20 Morning vs. evening chronotype; BRCA cis rs12760731 0.720 rs34194793 chr1:178329065 G/T cg00404053 chr1:178313656 RASAL2 0.62 8.48 0.32 1.55e-16 Obesity-related traits; BRCA cis rs7586879 0.616 rs6726199 chr2:25126328 G/C cg01884057 chr2:25150051 NA 0.35 9.26 0.34 2.97e-19 Body mass index; BRCA trans rs12310956 0.515 rs1405031 chr12:33958931 A/C cg26384229 chr12:38710491 ALG10B 0.48 10.6 0.39 2.73e-24 Morning vs. evening chronotype; BRCA cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg11890956 chr21:40555474 PSMG1 -0.82 -19.39 -0.61 3.15e-66 Cognitive function; BRCA cis rs7215564 0.818 rs34760119 chr17:78604583 G/T cg06153925 chr17:78755379 RPTOR 0.41 7.87 0.3 1.52e-14 Myopia (pathological); BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg00166722 chr3:10149974 C3orf24 0.59 11.74 0.42 5.94e-29 Alzheimer's disease; BRCA cis rs6750795 0.569 rs1667305 chr2:232403829 A/G cg19187155 chr2:232395269 NMUR1 0.69 17.47 0.57 3.91e-56 Height; BRCA cis rs7267979 1.000 rs1077889 chr20:25267893 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.65 0.36 1.14e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4363385 0.818 rs409986 chr1:153014741 A/C cg24667326 chr1:152973720 SPRR3 0.32 8.64 0.32 4.63e-17 Inflammatory skin disease; BRCA cis rs6570726 0.935 rs434298 chr6:145846873 G/A cg23711669 chr6:146136114 FBXO30 0.64 14.98 0.51 1.1e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs1577917 1.000 rs12208493 chr6:86662267 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.51 -13.42 -0.47 2.3e-36 Response to antipsychotic treatment; BRCA cis rs826838 0.616 rs9668847 chr12:38614669 C/T cg26384229 chr12:38710491 ALG10B 0.43 10.27 0.38 5.36e-23 Heart rate; BRCA cis rs2795502 0.554 rs1620395 chr10:43341185 G/A cg20628663 chr10:43360327 NA -0.49 -11.09 -0.4 3.07e-26 Blood protein levels; BRCA cis rs7903847 0.642 rs2297668 chr10:99160046 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.74 -0.33 2.11e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10504229 0.683 rs7827014 chr8:58132230 G/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs4555082 0.874 rs1008628 chr14:105722726 T/C cg13114125 chr14:105738426 BRF1 -0.48 -10.32 -0.38 3.26e-23 Mean platelet volume;Platelet distribution width; BRCA trans rs7829975 0.688 rs7827182 chr8:8380471 C/G cg16141378 chr3:129829833 LOC729375 -0.33 -8.16 -0.31 1.81e-15 Mood instability; BRCA cis rs4665809 0.878 rs4665826 chr2:26367503 A/T cg04944784 chr2:26401820 FAM59B 0.89 14.13 0.49 1.26e-39 Gut microbiome composition (summer); BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg04025307 chr7:1156635 C7orf50 0.51 8.34 0.31 4.59e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.57 -0.47 4.99e-37 Developmental language disorder (linguistic errors); BRCA cis rs12368653 0.693 rs2640610 chr12:58037435 T/A cg12615879 chr12:58013172 SLC26A10 0.28 7.92 0.3 1.03e-14 Multiple sclerosis; BRCA cis rs10744422 1.000 rs897385 chr12:123341297 A/G cg25930673 chr12:123319894 HIP1R -0.52 -7.93 -0.3 1.02e-14 Schizophrenia; BRCA cis rs6598163 0.517 rs10902453 chr12:132297091 G/T cg08236123 chr12:132219811 SFRS8 0.44 9.5 0.35 4.14e-20 Migraine; BRCA cis rs2153535 0.580 rs7341382 chr6:8470549 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg21573476 chr21:45109991 RRP1B -0.35 -9.09 -0.34 1.24e-18 Mean corpuscular volume; BRCA cis rs9287719 0.934 rs6432110 chr2:10738018 T/A cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs877282 0.945 rs877280 chr10:771599 C/T cg17470449 chr10:769945 NA 0.53 9.25 0.34 3.45e-19 Uric acid levels; BRCA cis rs7089973 0.584 rs4752322 chr10:116613258 A/C cg23260525 chr10:116636907 FAM160B1 0.31 8.18 0.31 1.55e-15 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs59918340 0.764 rs4961258 chr8:142232878 A/G cg23750338 chr8:142222470 SLC45A4 -0.5 -12.44 -0.44 5.54e-32 Immature fraction of reticulocytes; BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg27170947 chr2:26402098 FAM59B -0.81 -12.87 -0.45 6.96e-34 Gut microbiome composition (summer); BRCA cis rs9818758 0.607 rs11552724 chr3:49156473 C/G cg01304814 chr3:48885189 PRKAR2A 0.7 7.94 0.3 9.33e-15 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs2479724 0.935 rs1887718 chr6:41857691 C/T cg17623882 chr6:41773611 USP49 -0.39 -10.6 -0.39 2.79e-24 Menarche (age at onset); BRCA cis rs2204008 0.806 rs7305409 chr12:38349133 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.14 0.37 1.62e-22 Bladder cancer; BRCA cis rs10496034 1.000 rs4671993 chr2:55141989 T/C cg16098955 chr2:55172992 EML6 0.52 9.08 0.34 1.38e-18 Refractive astigmatism; BRCA cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.43 8.38 0.31 3.26e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs801193 1.000 rs3857688 chr7:66127806 G/A cg11764359 chr7:65958608 NA -0.67 -14.9 -0.51 2.48e-43 Aortic root size; BRCA cis rs56104184 0.725 rs4347731 chr19:49385154 A/G cg15549821 chr19:49342101 PLEKHA4 -0.62 -8.33 -0.31 4.92e-16 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs12618769 0.597 rs10514774 chr2:99028695 A/G cg10123293 chr2:99228465 UNC50 0.4 7.97 0.3 7.5e-15 Bipolar disorder; BRCA cis rs6964587 1.000 rs56072181 chr7:91690457 A/G cg17063962 chr7:91808500 NA 0.53 12.5 0.44 3.23e-32 Breast cancer; BRCA cis rs514406 0.584 rs11205997 chr1:53195271 G/C cg08859206 chr1:53392774 SCP2 0.41 8.03 0.3 4.78e-15 Monocyte count; BRCA cis rs6570726 0.935 rs110289 chr6:145865176 C/G cg23711669 chr6:146136114 FBXO30 0.64 14.79 0.5 8.86e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs4975616 0.869 rs452384 chr5:1330840 T/C cg26373071 chr5:1325741 CLPTM1L 0.5 12.35 0.44 1.36e-31 Lung cancer; BRCA cis rs2073300 0.609 rs74809795 chr20:23372383 A/C cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.36e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg21770322 chr7:97807741 LMTK2 0.44 11.53 0.41 4.62e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs10751667 1.000 rs7394449 chr11:962190 T/C ch.11.42038R chr11:967971 AP2A2 0.58 19.18 0.6 4.23e-65 Alzheimer's disease (late onset); BRCA cis rs2882667 0.893 rs7717375 chr5:138291405 A/G cg04439458 chr5:138467593 SIL1 -0.31 -8.31 -0.31 5.61e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3862030 0.839 rs2281880 chr10:104269217 G/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -11.89 -0.43 1.36e-29 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA trans rs2204008 0.548 rs8189475 chr12:38037115 C/T cg06521331 chr12:34319734 NA -0.41 -8.16 -0.31 1.76e-15 Bladder cancer; BRCA cis rs6831352 0.918 rs29001202 chr4:100053782 T/A cg13256891 chr4:100009986 ADH5 -0.53 -9.87 -0.36 1.82e-21 Alcohol dependence; BRCA cis rs7914558 0.932 rs4307650 chr10:104959852 C/A cg04362960 chr10:104952993 NT5C2 0.41 9.86 0.36 1.85e-21 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg24675658 chr1:53192096 ZYG11B -0.52 -11.39 -0.41 1.74e-27 Monocyte count; BRCA cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg04166393 chr7:2884313 GNA12 0.39 8.4 0.32 2.83e-16 Height; BRCA cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg00083206 chr6:110721305 DDO 0.38 9.03 0.34 1.97e-18 Platelet distribution width; BRCA cis rs495337 0.509 rs8123655 chr20:48518254 G/A cg17835207 chr20:48524531 SPATA2 0.42 8.95 0.33 3.82e-18 Psoriasis; BRCA cis rs7607369 0.759 rs10179708 chr2:219390967 T/A cg02176678 chr2:219576539 TTLL4 -0.51 -12.93 -0.46 4.09e-34 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs73086581 1.000 rs17215054 chr20:3944779 T/C cg02187196 chr20:3869020 PANK2 0.54 9.62 0.36 1.48e-20 Response to antidepressants in depression; BRCA cis rs7412746 0.658 rs12097963 chr1:150870450 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.98 0.3 6.93e-15 Melanoma; BRCA cis rs2180341 0.960 rs7753913 chr6:127671296 A/G cg27446573 chr6:127587934 RNF146 0.89 20.5 0.63 3.86e-72 Breast cancer; BRCA cis rs2011503 1.000 rs17684164 chr19:19626769 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs13095912 1.000 rs13100034 chr3:185318804 G/A cg11274856 chr3:185301563 NA 0.34 8.53 0.32 1.06e-16 Systolic blood pressure; BRCA cis rs6582630 0.598 rs10880645 chr12:38556172 G/A cg26384229 chr12:38710491 ALG10B -0.45 -10.25 -0.38 6.02e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -8.23 -0.31 1.04e-15 Electroencephalogram traits; BRCA cis rs1707322 1.000 rs10890355 chr1:46317348 G/A cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.65e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17401966 0.838 rs1013953 chr1:10319459 T/A cg03954927 chr1:10346856 KIF1B 0.43 13.44 0.47 2e-36 Hepatocellular carcinoma; BRCA cis rs67614146 1 rs67614146 chr6:87821827 AC/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.38 -11.16 -0.4 1.56e-26 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg11707556 chr5:10655725 ANKRD33B 0.42 9.47 0.35 5.41e-20 Coronary artery disease; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg04709771 chr16:646395 RAB40C 0.44 11.12 0.4 2.31e-26 Height; BRCA cis rs9649213 0.613 rs10953256 chr7:97951886 G/C cg21770322 chr7:97807741 LMTK2 0.41 10.97 0.4 8.81e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs9486715 0.867 rs4839834 chr6:96882109 C/A cg06623918 chr6:96969491 KIAA0776 0.86 23.81 0.69 3.28e-90 Headache; BRCA cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg15017067 chr4:17643749 FAM184B 0.28 8.62 0.32 5.26e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 0.865 rs9996417 chr4:120295862 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.56 0.42 3.34e-28 Corneal astigmatism; BRCA cis rs4665809 0.549 rs62130460 chr2:26472718 T/C cg08067268 chr2:26466485 HADHB;HADHA 0.54 8.51 0.32 1.26e-16 Gut microbiome composition (summer); BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -13.02 -0.46 1.58e-34 Platelet count; BRCA cis rs875971 0.545 rs73142245 chr7:65691649 A/G cg11764359 chr7:65958608 NA 0.63 10.9 0.4 1.68e-25 Aortic root size; BRCA cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.58 0.39 3.38e-24 Motion sickness; BRCA cis rs514406 0.679 rs960570 chr1:53237763 A/G cg01802117 chr1:53393560 SCP2 0.41 8.59 0.32 6.79e-17 Monocyte count; BRCA cis rs72772090 0.539 rs56319744 chr5:96141938 G/C cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -11.66 -0.42 1.25e-28 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs34172651 0.876 rs11074653 chr16:24795959 C/T cg00339695 chr16:24857497 SLC5A11 0.34 7.89 0.3 1.35e-14 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs28802909 chr4:99039410 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 4.98e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs8072100 0.790 rs3760371 chr17:45695914 T/C cg19784903 chr17:45786737 TBKBP1 0.36 8.49 0.32 1.47e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs4332037 0.510 rs11764040 chr7:1884830 G/C cg23422044 chr7:1970798 MAD1L1 -0.47 -9.92 -0.37 1.17e-21 Bipolar disorder; BRCA cis rs6964587 1.000 rs7785971 chr7:91736794 T/A cg17063962 chr7:91808500 NA 0.59 13.94 0.48 9.79e-39 Breast cancer; BRCA cis rs10927875 0.722 rs6696912 chr1:16338474 T/C cg21385522 chr1:16154831 NA 0.46 8.46 0.32 1.87e-16 Dilated cardiomyopathy; BRCA cis rs4642101 0.824 rs9825233 chr3:12843368 A/G cg24848339 chr3:12840334 CAND2 -0.41 -10.46 -0.38 9.49e-24 QRS complex (12-leadsum); BRCA cis rs6570726 0.935 rs388394 chr6:145852689 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.67 0.5 3.38e-42 Lobe attachment (rater-scored or self-reported); BRCA trans rs2204008 0.715 rs11514282 chr12:38169056 G/T cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs4631830 0.863 rs2843550 chr10:51521452 C/T cg20129853 chr10:51489980 NA -0.29 -7.9 -0.3 1.19e-14 Prostate-specific antigen levels; BRCA cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg16179182 chr5:140090404 VTRNA1-1 0.46 10.92 0.4 1.43e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs6582630 0.502 rs1115515 chr12:38279830 C/T cg26384229 chr12:38710491 ALG10B 0.7 15.96 0.53 1.67e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs3772130 0.923 rs28674947 chr3:121529421 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.91 0.4 1.63e-25 Cognitive performance; BRCA cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg15605315 chr1:45957053 TESK2 0.46 9.24 0.34 3.67e-19 High light scatter reticulocyte count; BRCA cis rs4819052 0.851 rs1056100 chr21:46678711 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.59 12.99 0.46 2.19e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.15 21.61 0.65 3.58e-78 Platelet count; BRCA cis rs921968 0.541 rs620596 chr2:219462419 G/A cg02176678 chr2:219576539 TTLL4 0.46 12.15 0.43 1.04e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs6582630 0.519 rs12819814 chr12:38332568 G/C cg26384229 chr12:38710491 ALG10B 0.69 16.02 0.54 8.05e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs13217239 0.585 rs114919438 chr6:26963792 T/C cg12292205 chr6:26970375 C6orf41 -0.6 -14.18 -0.49 7.28e-40 Schizophrenia; BRCA cis rs9300255 0.602 rs1727317 chr12:123618942 T/C cg00376283 chr12:123451042 ABCB9 0.54 10.8 0.39 4.16e-25 Neutrophil percentage of white cells; BRCA cis rs7618501 0.699 rs9821675 chr3:49902544 A/G cg05623727 chr3:50126028 RBM5 0.43 10.09 0.37 2.63e-22 Intelligence (multi-trait analysis); BRCA cis rs10880689 1 rs10880689 chr12:37930102 A/G cg26384229 chr12:38710491 ALG10B 0.67 15.12 0.51 2.21e-44 Resting heart rate; BRCA trans rs941408 1.000 rs2260416 chr19:2796355 G/A cg22153745 chr1:153894579 GATAD2B -0.49 -9.5 -0.35 4.18e-20 Total cholesterol levels; BRCA cis rs3770081 1.000 rs17584578 chr2:86307624 A/G cg23655155 chr2:86332777 POLR1A;PTCD3 0.58 8.28 0.31 7.12e-16 Facial emotion recognition (sad faces); BRCA cis rs4321325 0.733 rs4284779 chr2:127946500 T/C cg11380483 chr2:127933992 NA 0.43 8.47 0.32 1.69e-16 Protein C levels; BRCA cis rs4766646 0.600 rs3782893 chr12:110293678 G/C cg01252219 chr12:110302105 GLTP 0.36 7.98 0.3 6.65e-15 Metabolite levels (MHPG); BRCA cis rs1165668 0.727 rs2722176 chr12:104313943 T/C cg21863207 chr12:104234989 NT5DC3 0.39 7.99 0.3 6.5e-15 Coronary heart disease (SNP X SNP interaction); BRCA cis rs4664304 0.620 rs1828480 chr2:160720384 G/A cg01092293 chr2:160761427 LY75 0.36 8.51 0.32 1.24e-16 Crohn's disease;Inflammatory bowel disease; BRCA trans rs2840044 0.711 rs225301 chr17:33922411 T/A cg19694781 chr19:47549865 TMEM160 -0.75 -15.59 -0.52 1.11e-46 Response to radiotherapy in cancer (late toxicity); BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg25036284 chr2:26402008 FAM59B -0.64 -10.63 -0.39 2.11e-24 Gut microbiome composition (summer); BRCA cis rs507080 0.845 rs510408 chr11:118558901 G/C cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 11.44 0.41 1.08e-27 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs12477438 0.765 rs2167930 chr2:99592551 A/T cg08885076 chr2:99613938 TSGA10 -0.6 -13.44 -0.47 1.91e-36 Chronic sinus infection; BRCA cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg08999081 chr20:33150536 PIGU 0.47 12.95 0.46 3.15e-34 Glomerular filtration rate (creatinine); BRCA cis rs965469 0.947 rs965470 chr20:3381588 C/G cg25506879 chr20:3388711 C20orf194 -0.52 -10.22 -0.37 8.29e-23 IFN-related cytopenia; BRCA trans rs61931739 0.963 rs3912355 chr12:34079616 A/G cg26384229 chr12:38710491 ALG10B 0.41 9.14 0.34 8.15e-19 Morning vs. evening chronotype; BRCA cis rs66887589 0.870 rs10518336 chr4:120522934 G/A cg09307838 chr4:120376055 NA 0.43 8.98 0.33 3.01e-18 Diastolic blood pressure; BRCA cis rs8062405 1.000 rs4788095 chr16:28831359 T/C cg09754948 chr16:28834200 ATXN2L 0.46 9.12 0.34 9.55e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9790314 0.846 rs4560315 chr3:160982132 G/T cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA cis rs8062405 1.000 rs11861174 chr16:28871989 A/G cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs701145 0.556 rs191651 chr3:153973887 T/G cg16511985 chr3:153974050 SGEF 0.47 10.69 0.39 1.15e-24 Coronary artery disease; BRCA cis rs367943 0.966 rs348932 chr5:112812457 G/A cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs75229567 0.618 rs11177819 chr12:70134836 T/G cg10114359 chr12:70132523 RAB3IP 0.76 9.87 0.36 1.76e-21 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs703842 0.963 rs2291617 chr12:58166403 T/G cg00677455 chr12:58241039 CTDSP2 0.62 14.27 0.49 2.5e-40 Multiple sclerosis; BRCA cis rs1011018 0.628 rs73158611 chr7:139425430 G/C cg03224163 chr7:139420300 HIPK2 -0.54 -9.18 -0.34 5.9e-19 Systolic blood pressure; BRCA cis rs12618769 0.572 rs4851141 chr2:99112966 A/C cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg13397359 chr6:42928475 GNMT 0.75 19.14 0.6 6.8e-65 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6952407 1 rs6952407 chr7:66045512 A/G cg18876405 chr7:65276391 NA -0.62 -15.44 -0.52 5.85e-46 Cotinine glucuronidation; BRCA cis rs11690935 0.802 rs34636594 chr2:172911094 A/G cg13550731 chr2:172543902 DYNC1I2 -0.88 -24.35 -0.69 3.78e-93 Schizophrenia; BRCA cis rs4819052 0.851 rs2838839 chr21:46667858 C/G cg06618935 chr21:46677482 NA 0.36 8.02 0.3 4.89e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs763121 0.853 rs5750668 chr22:39079964 T/C cg06022373 chr22:39101656 GTPBP1 0.75 18.43 0.59 3.62e-61 Menopause (age at onset); BRCA cis rs11190604 1.000 rs2489034 chr10:102319192 C/T cg07080220 chr10:102295463 HIF1AN 0.6 14.26 0.49 3.07e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg04317338 chr11:64019027 PLCB3 0.55 9.57 0.35 2.29e-20 Mean platelet volume; BRCA cis rs3784262 0.869 rs12903792 chr15:58261280 C/T cg12031962 chr15:58353849 ALDH1A2 -0.46 -12.35 -0.44 1.42e-31 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs12586317 0.511 rs11540758 chr14:35498485 C/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.22 -0.37 8.46e-23 Psoriasis; BRCA cis rs9486719 1.000 rs13208422 chr6:96892119 C/T cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs8044868 0.530 rs12446480 chr16:72056757 A/G cg16558253 chr16:72132732 DHX38 -0.39 -9.5 -0.35 4.11e-20 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA trans rs1459104 0.789 rs28896554 chr11:54812637 C/T cg15704280 chr7:45808275 SEPT13 0.63 8.25 0.31 8.87e-16 Body mass index; BRCA cis rs9420 0.961 rs11604325 chr11:57497011 C/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.43 -0.44 6.13e-32 Schizophrenia; BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.34 -0.35 1.62e-19 Total body bone mineral density; BRCA cis rs1215050 0.791 rs1215055 chr4:98865454 C/T cg05340658 chr4:99064831 C4orf37 -0.43 -9.64 -0.36 1.31e-20 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4689388 0.890 rs4501291 chr4:6298582 C/T cg25554036 chr4:6271136 WFS1 0.37 8.83 0.33 1.01e-17 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7618915 0.524 rs10433615 chr3:52638482 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.03 0.4 4.9e-26 Bipolar disorder; BRCA cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.34 -0.44 1.64e-31 Developmental language disorder (linguistic errors); BRCA trans rs7980799 0.682 rs1601006 chr12:33629519 C/T cg26384229 chr12:38710491 ALG10B -0.48 -10.34 -0.38 2.92e-23 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs4566357 0.615 rs10178260 chr2:227914458 G/T cg11843606 chr2:227700838 RHBDD1 -0.41 -9.26 -0.34 3.06e-19 Coronary artery disease; BRCA cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg00686598 chr14:53173677 PSMC6 1.15 15.97 0.53 1.5e-48 Alzheimer's disease (late onset); BRCA trans rs453301 0.653 rs7016139 chr8:8895470 A/G cg16141378 chr3:129829833 LOC729375 0.33 7.98 0.3 6.77e-15 Joint mobility (Beighton score); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg03188948 chr7:1209495 NA 0.69 15.13 0.51 1.98e-44 Longevity;Endometriosis; BRCA cis rs66569888 0.523 rs4522599 chr2:106926004 G/C cg16099169 chr2:106886729 NA 0.6 11.91 0.43 1.07e-29 Facial morphology (factor 23); BRCA cis rs2251381 0.750 rs2251186 chr21:30528880 G/A cg08807101 chr21:30365312 RNF160 0.62 13.24 0.46 1.51e-35 Selective IgA deficiency; BRCA cis rs1348850 0.519 rs13034781 chr2:178523550 C/A cg22681709 chr2:178499509 PDE11A -0.38 -8.24 -0.31 9.55e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11874712 1.000 rs9945751 chr18:43673265 G/A cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.09 0.3 2.98e-15 Migraine - clinic-based; BRCA cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.1 0.4 2.58e-26 Bipolar disorder; BRCA cis rs2835872 0.758 rs1709832 chr21:39038167 A/C cg06728970 chr21:39037746 KCNJ6 0.43 12.06 0.43 2.67e-30 Electroencephalographic traits in alcoholism; BRCA cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg04450456 chr4:17643702 FAM184B 0.38 11.12 0.4 2.16e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1797081 0.840 rs10904820 chr10:16848473 A/G cg23933602 chr10:16859644 RSU1 0.85 23.2 0.68 7.44e-87 Platelet distribution width; BRCA trans rs9329221 0.725 rs11250001 chr8:10255901 G/A cg15556689 chr8:8085844 FLJ10661 -0.33 -8.04 -0.3 4.4e-15 Neuroticism; BRCA cis rs875971 0.545 rs10950025 chr7:65623933 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.11 0.37 2.23e-22 Aortic root size; BRCA cis rs9640161 0.789 rs6964110 chr7:150041836 A/C cg12556325 chr7:150026731 C7orf29;LRRC61 -0.48 -12.03 -0.43 3.55e-30 Blood protein levels;Circulating chemerin levels; BRCA cis rs3925075 0.553 rs9888907 chr16:31349040 A/G cg02846316 chr16:31340340 ITGAM 0.42 9.07 0.34 1.51e-18 IgA nephropathy; BRCA cis rs77686669 1 rs77686669 chr7:99744572 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.46 8.64 0.32 4.64e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.54 7.89 0.3 1.29e-14 Cerebrospinal P-tau181p levels; BRCA cis rs6901250 0.655 rs1117046 chr6:117136978 G/C cg12892004 chr6:117198278 RFX6 0.37 9.12 0.34 9.43e-19 C-reactive protein levels; BRCA cis rs4819052 1.000 rs4819052 chr21:46699777 A/G cg11663144 chr21:46675770 NA -0.5 -10.11 -0.37 2.23e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2243480 1.000 rs7804223 chr7:65664559 T/G cg18252515 chr7:66147081 NA 1.05 15.64 0.53 6.07e-47 Diabetic kidney disease; BRCA cis rs7618915 0.501 rs2336146 chr3:52626646 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.17 0.46 3.12e-35 Bipolar disorder; BRCA cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg25319279 chr11:5960081 NA -0.4 -7.84 -0.3 1.95e-14 DNA methylation (variation); BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs8072100 0.581 rs4267364 chr17:45781264 A/G cg25173405 chr17:45401733 C17orf57 -0.45 -8.77 -0.33 1.67e-17 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs1941687 0.563 rs7232237 chr18:31324934 C/T cg15819921 chr19:927150 ARID3A 0.42 7.96 0.3 7.82e-15 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg22974920 chr21:40686053 BRWD1 -0.42 -9.21 -0.34 4.81e-19 Cognitive function; BRCA cis rs7598759 0.712 rs997400 chr2:232332847 C/T cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.1e-14 Noise-induced hearing loss; BRCA cis rs2836974 0.932 rs2150415 chr21:40615367 A/G cg17971929 chr21:40555470 PSMG1 0.77 17.81 0.58 6.22e-58 Cognitive function; BRCA trans rs11098499 0.863 rs1010740 chr4:120463409 C/T cg25214090 chr10:38739885 LOC399744 -0.55 -12.11 -0.43 1.6e-30 Corneal astigmatism; BRCA cis rs1153858 0.943 rs28605551 chr15:45641720 C/T cg21132104 chr15:45694354 SPATA5L1 0.7 15.29 0.52 3.3e-45 Homoarginine levels; BRCA trans rs617791 0.530 rs735942 chr11:65749337 A/G cg17712092 chr4:129076599 LARP1B -0.49 -10.84 -0.39 2.97e-25 Breast cancer; BRCA trans rs61931739 0.926 rs1995966 chr12:34095420 G/A cg26384229 chr12:38710491 ALG10B -0.41 -8.99 -0.34 2.85e-18 Morning vs. evening chronotype; BRCA trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg06636001 chr8:8085503 FLJ10661 0.52 10.93 0.4 1.31e-25 Neuroticism; BRCA cis rs1005277 0.522 rs289648 chr10:37971837 T/C cg25427524 chr10:38739819 LOC399744 -0.64 -15.08 -0.51 3.58e-44 Extrinsic epigenetic age acceleration; BRCA cis rs10992471 0.603 rs10761160 chr9:95208701 A/T cg14631576 chr9:95140430 CENPP -0.39 -9.31 -0.35 1.96e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs16976116 0.901 rs73409851 chr15:55502516 G/A cg11288833 chr15:55489084 RSL24D1 0.47 10.73 0.39 8.2e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg24082983 chr21:31802169 KRTAP13-4 0.34 8.76 0.33 1.78e-17 HDL cholesterol; BRCA cis rs17270561 0.636 rs4360128 chr6:25734558 A/G cg16482183 chr6:26056742 HIST1H1C 0.46 8.92 0.33 4.88e-18 Iron status biomarkers; BRCA cis rs75229567 0.618 rs11495622 chr12:70161286 G/A cg10114359 chr12:70132523 RAB3IP 0.76 9.71 0.36 7.03e-21 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs769267 0.895 rs2916073 chr19:19528324 T/G cg01262667 chr19:19385393 TM6SF2 0.41 10.68 0.39 1.28e-24 Tonsillectomy; BRCA cis rs826838 0.935 rs11169508 chr12:39173385 C/T cg26384229 chr12:38710491 ALG10B 0.8 20.33 0.63 2.96e-71 Heart rate; BRCA cis rs17092148 0.731 rs35507767 chr20:33361364 A/T cg16810054 chr20:33298113 TP53INP2 -0.49 -11.22 -0.41 8.24e-27 Neuroticism; BRCA cis rs875971 0.862 rs28470208 chr7:65584700 A/G cg11764359 chr7:65958608 NA -0.75 -16.75 -0.55 1.72e-52 Aortic root size; BRCA cis rs7560272 0.538 rs6732812 chr2:73922475 T/C cg20560298 chr2:73613845 ALMS1 0.35 9.0 0.34 2.53e-18 Schizophrenia; BRCA cis rs9649465 0.561 rs600081 chr7:123414591 A/T cg03229431 chr7:123269106 ASB15 0.44 10.25 0.38 6.36e-23 Migraine; BRCA cis rs651907 0.712 rs796410 chr3:101610189 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.39 9.1 0.34 1.18e-18 Colorectal cancer; BRCA trans rs1994135 0.669 rs11052747 chr12:33697913 C/G cg26384229 chr12:38710491 ALG10B 0.44 9.33 0.35 1.7e-19 Resting heart rate; BRCA cis rs2073300 1.000 rs6137960 chr20:23442886 G/A cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs3733585 0.673 rs10018204 chr4:9964570 C/T cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6964587 0.869 rs6964050 chr7:91482418 C/T cg17063962 chr7:91808500 NA -0.53 -12.42 -0.44 7.33e-32 Breast cancer; BRCA cis rs7666738 0.830 rs1593570 chr4:99017058 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg06552810 chr11:31128660 NA -0.39 -8.58 -0.32 7.04e-17 Red blood cell count; BRCA cis rs8180040 0.932 rs62248599 chr3:47516728 G/A cg16586182 chr3:47516702 SCAP 0.65 15.14 0.51 1.73e-44 Colorectal cancer; BRCA cis rs3008870 1.000 rs2815361 chr1:67494591 G/T cg08660285 chr1:67390436 MIER1;WDR78 0.93 20.7 0.63 3.04e-73 Lymphocyte percentage of white cells; BRCA cis rs11971779 0.584 rs6942519 chr7:139070090 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.32 0.38 3.39e-23 Diisocyanate-induced asthma; BRCA trans rs6582630 0.555 rs1829583 chr12:38423161 T/C cg06521331 chr12:34319734 NA 0.46 9.05 0.34 1.74e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs60871478 0.636 rs10245785 chr7:894422 T/C cg27478167 chr7:817139 HEATR2 0.54 10.57 0.39 3.63e-24 Cerebrospinal P-tau181p levels; BRCA cis rs7613875 0.620 rs2526747 chr3:50082914 C/G cg05623727 chr3:50126028 RBM5 0.51 12.34 0.44 1.59e-31 Body mass index; BRCA cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg14196790 chr5:131705035 SLC22A5 -0.42 -10.24 -0.38 7.13e-23 Breast cancer;Mosquito bite size; BRCA cis rs4665809 0.590 rs17528653 chr2:26507724 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.03 20.77 0.63 1.34e-73 Gut microbiome composition (summer); BRCA cis rs12579753 0.879 rs12829053 chr12:82161926 T/A cg07988820 chr12:82153109 PPFIA2 -0.69 -11.83 -0.42 2.39e-29 Resting heart rate; BRCA cis rs12200560 0.505 rs4839848 chr6:97076577 G/A cg06623918 chr6:96969491 KIAA0776 0.53 12.7 0.45 4.04e-33 Coronary heart disease; BRCA cis rs10782582 0.609 rs1159215 chr1:76317869 A/T cg03433033 chr1:76189801 ACADM -0.39 -8.21 -0.31 1.23e-15 Daytime sleep phenotypes; BRCA trans rs330048 0.545 rs11774353 chr8:9153127 C/T cg06636001 chr8:8085503 FLJ10661 0.61 12.53 0.44 2.36e-32 Systemic lupus erythematosus; BRCA cis rs11608355 0.515 rs12818537 chr12:109902150 C/T cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs35123781 1.000 rs673632 chr5:139057237 G/T cg05227215 chr5:139057496 CXXC5 0.35 8.42 0.32 2.45e-16 Schizophrenia; BRCA cis rs3806843 0.766 rs702397 chr5:140050265 A/G cg11822812 chr5:140052017 DND1 -0.32 -8.92 -0.33 4.91e-18 Depressive symptoms (multi-trait analysis); BRCA cis rs2625529 0.668 rs72733369 chr15:72567260 G/A cg16672083 chr15:72433130 SENP8 -0.81 -16.93 -0.56 2.05e-53 Red blood cell count; BRCA cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg08754478 chr10:133766260 PPP2R2D -0.69 -14.15 -0.49 9.24e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2652822 0.525 rs11632192 chr15:63515946 A/G cg02713581 chr15:63449717 RPS27L 0.41 8.3 0.31 6.28e-16 Metabolic traits; BRCA cis rs9814567 0.964 rs9833753 chr3:134213665 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs8114671 0.586 rs6087634 chr20:33413809 G/A cg07148914 chr20:33460835 GGT7 0.36 8.01 0.3 5.62e-15 Height; BRCA cis rs7301016 0.846 rs17732089 chr12:63023658 A/G cg11441379 chr12:63026424 NA -0.49 -8.91 -0.33 5.25e-18 IgG glycosylation; BRCA cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg12310025 chr6:25882481 NA -0.55 -12.29 -0.44 2.71e-31 Intelligence (multi-trait analysis); BRCA cis rs270601 0.913 rs273916 chr5:131659830 C/A cg07395648 chr5:131743802 NA -0.36 -8.01 -0.3 5.42e-15 Acylcarnitine levels; BRCA cis rs4722166 0.597 rs2069845 chr7:22770149 G/A cg26061582 chr7:22766209 IL6 0.39 9.39 0.35 1.02e-19 Lung cancer; BRCA cis rs4820539 1.000 rs5759595 chr22:23471624 G/A cg14186256 chr22:23484241 RTDR1 0.78 24.33 0.69 5.11e-93 Bone mineral density; BRCA cis rs17270561 0.609 rs1165208 chr6:25803904 G/A cg17691542 chr6:26056736 HIST1H1C 0.43 9.25 0.34 3.23e-19 Iron status biomarkers; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.6 -12.55 -0.44 1.84e-32 Lymphocyte counts; BRCA cis rs992157 0.835 rs11677953 chr2:219121663 G/A cg00012203 chr2:219082015 ARPC2 -0.52 -10.01 -0.37 5.22e-22 Colorectal cancer; BRCA cis rs9560113 1.000 rs9560107 chr13:112180146 G/A cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg05863683 chr7:1912471 MAD1L1 0.4 8.52 0.32 1.13e-16 Bipolar disorder and schizophrenia; BRCA cis rs2243480 1.000 rs1546059 chr7:65654709 C/A cg18252515 chr7:66147081 NA 1.06 16.03 0.54 7.81e-49 Diabetic kidney disease; BRCA cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10046574 0.517 rs7782727 chr7:135200299 A/G cg27474649 chr7:135195673 CNOT4 0.67 11.09 0.4 3.01e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9457247 0.588 rs35171809 chr6:167432766 A/G cg23791538 chr6:167370224 RNASET2 -0.32 -7.85 -0.3 1.78e-14 Crohn's disease; BRCA cis rs2777491 0.915 rs8032838 chr15:41605632 G/A cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.87 -0.48 1.89e-38 Ulcerative colitis; BRCA cis rs765787 0.530 rs4270107 chr15:45535350 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.32 -0.41 3.19e-27 Uric acid levels; BRCA cis rs12618769 0.597 rs3769719 chr2:99124404 T/C cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg13047869 chr3:10149882 C3orf24 0.59 12.52 0.44 2.55e-32 Alzheimer's disease; BRCA cis rs1003719 0.762 rs6517402 chr21:38447423 A/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.17 0.49 7.56e-40 Eye color traits; BRCA cis rs7618915 0.547 rs11720432 chr3:52672742 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.36 -0.31 3.91e-16 Bipolar disorder; BRCA cis rs4927850 1.000 rs7614767 chr3:195753451 C/T cg00031303 chr3:195681400 NA 0.45 8.59 0.32 6.74e-17 Pancreatic cancer; BRCA cis rs3815148 0.569 rs12705406 chr7:106792554 A/G cg02696742 chr7:106810147 HBP1 0.68 8.47 0.32 1.65e-16 Osteoarthritis; BRCA cis rs4665809 0.652 rs10779956 chr2:26405985 A/G cg22920501 chr2:26401640 FAM59B -0.94 -16.53 -0.55 2.36e-51 Gut microbiome composition (summer); BRCA cis rs1506636 1.000 rs684548 chr7:123397102 A/T cg03229431 chr7:123269106 ASB15 0.61 13.66 0.48 1.88e-37 Plateletcrit;Platelet count; BRCA cis rs11030122 0.702 rs4910868 chr11:3980224 A/C cg18678763 chr11:4115507 RRM1 -0.35 -7.87 -0.3 1.53e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs10754283 0.967 rs1953821 chr1:90107098 C/G cg21401794 chr1:90099060 LRRC8C 0.45 10.78 0.39 5.23e-25 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs17401966 1.000 rs2275424 chr1:10356562 C/A cg15208524 chr1:10270712 KIF1B 0.4 8.63 0.32 4.7e-17 Hepatocellular carcinoma; BRCA cis rs9473147 0.516 rs2151974 chr6:47515630 G/A cg12968598 chr6:47444699 CD2AP 0.44 9.7 0.36 7.41e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs7772486 0.719 rs702307 chr6:145993454 C/G cg23711669 chr6:146136114 FBXO30 -0.79 -18.87 -0.6 1.73e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs11725095 chr4:99009711 T/A cg17366294 chr4:99064904 C4orf37 0.45 10.76 0.39 6.07e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9393692 0.875 rs6939589 chr6:26289203 C/T cg13736514 chr6:26305472 NA 0.32 10.93 0.4 1.33e-25 Educational attainment; BRCA cis rs5771242 0.518 rs7290465 chr22:50679758 C/T cg16473166 chr22:50639996 SELO -0.59 -11.91 -0.43 1.14e-29 Lung function (forced expiratory flow during mid-portion (25% and 75%) of forced vital capacity); BRCA trans rs2727020 0.521 rs4980445 chr11:49570183 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -9.76 -0.36 4.42e-21 Coronary artery disease; BRCA cis rs35110281 0.667 rs7282122 chr21:45082365 G/A cg04455712 chr21:45112962 RRP1B 0.47 12.57 0.45 1.53e-32 Mean corpuscular volume; BRCA cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA trans rs66887589 0.967 rs6844263 chr4:120433807 A/G cg25214090 chr10:38739885 LOC399744 0.35 8.12 0.31 2.48e-15 Diastolic blood pressure; BRCA cis rs1707322 1.000 rs785478 chr1:46491635 C/T cg03146154 chr1:46216737 IPP -0.45 -10.07 -0.37 3.16e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs526821 0.595 rs504661 chr11:55312683 A/G cg11707556 chr5:10655725 ANKRD33B -0.36 -8.19 -0.31 1.4e-15 Pediatric bone mineral density (spine); BRCA cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg17366294 chr4:99064904 C4orf37 0.51 11.46 0.41 8.52e-28 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.534 rs12831685 chr12:34038392 C/T cg26384229 chr12:38710491 ALG10B 0.53 11.45 0.41 9.8e-28 Morning vs. evening chronotype; BRCA cis rs1994135 0.617 rs10844644 chr12:33735871 A/G cg06521331 chr12:34319734 NA -0.44 -8.16 -0.31 1.83e-15 Resting heart rate; BRCA cis rs4481887 0.861 rs10788776 chr1:248479177 T/C cg00666640 chr1:248458726 OR2T12 0.29 8.21 0.31 1.26e-15 Common traits (Other); BRCA cis rs7267979 0.966 rs6037083 chr20:25290543 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.24 -0.31 9.54e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12477438 0.520 rs2964969 chr2:99782811 G/A cg08885076 chr2:99613938 TSGA10 0.45 10.46 0.38 9.8599999999999993e-24 Chronic sinus infection; BRCA cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg11833968 chr6:79620685 NA -0.46 -10.29 -0.38 4.47e-23 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.91 0.36 1.3e-21 Gut microbiome composition (summer); BRCA cis rs897984 0.542 rs59061704 chr16:31062704 G/C cg00531865 chr16:30841666 NA -0.35 -8.22 -0.31 1.13e-15 Dementia with Lewy bodies; BRCA cis rs13064411 0.735 rs7631138 chr3:113231925 A/T cg18753928 chr3:113234510 CCDC52 -0.58 -12.25 -0.44 3.88e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7592578 0.766 rs12472081 chr2:191398545 G/A cg11845111 chr2:191398756 TMEM194B -0.83 -14.48 -0.5 2.77e-41 Diastolic blood pressure; BRCA cis rs7267979 1.000 rs2257496 chr20:25279315 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.2e-21 Liver enzyme levels (alkaline phosphatase); BRCA trans rs11098499 0.863 rs11098532 chr4:120490726 C/A cg25214090 chr10:38739885 LOC399744 0.54 11.89 0.43 1.36e-29 Corneal astigmatism; BRCA cis rs875971 0.825 rs28480509 chr7:66099224 A/G cg18876405 chr7:65276391 NA -0.48 -10.52 -0.38 5.64e-24 Aortic root size; BRCA cis rs7833986 0.501 rs72653962 chr8:56997505 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.7 12.99 0.46 2.13e-34 Height; BRCA cis rs2014572 0.933 rs8107516 chr19:57758445 A/G cg24459738 chr19:57751996 ZNF805 -0.37 -8.63 -0.32 4.85e-17 Hyperactive-impulsive symptoms; BRCA cis rs738322 0.511 rs2267370 chr22:38576826 G/A cg25457927 chr22:38595422 NA -0.36 -11.97 -0.43 6.17e-30 Cutaneous nevi; BRCA cis rs703842 1.000 rs3782130 chr12:58161898 G/C cg00677455 chr12:58241039 CTDSP2 0.63 14.61 0.5 6.29e-42 Multiple sclerosis; BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07256732 chr16:621771 PIGQ -0.34 -9.02 -0.34 2.15e-18 Height; BRCA cis rs12949688 1.000 rs886925 chr17:55817649 G/C cg12582317 chr17:55822272 NA 0.32 8.05 0.3 3.98e-15 Schizophrenia; BRCA cis rs4363385 0.747 rs2339496 chr1:152970719 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.14e-18 Inflammatory skin disease; BRCA cis rs10174077 0.874 rs6750342 chr2:152485754 A/G cg06191203 chr2:152266755 RIF1 -0.35 -10.09 -0.37 2.5e-22 Squamous cell lung carcinoma; BRCA cis rs72772090 0.539 rs11749811 chr5:96115925 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.09 -0.43 1.97e-30 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9986765 0.609 rs73452600 chr7:142828104 C/A cg15652212 chr7:142981776 TMEM139 0.62 9.86 0.36 1.87e-21 Cancer;Dermatomyositis; BRCA cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg06618935 chr21:46677482 NA -0.38 -8.42 -0.32 2.4e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9811920 0.625 rs9847283 chr3:99910320 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.38 -8.83 -0.33 1.01e-17 Axial length; BRCA cis rs10256972 0.681 rs6979076 chr7:1116247 C/T cg23978390 chr7:1156363 C7orf50 -0.46 -10.59 -0.39 3.05e-24 Longevity;Endometriosis; BRCA cis rs1008375 0.898 rs7678654 chr4:17575376 T/G cg04450456 chr4:17643702 FAM184B 0.41 12.13 0.43 1.25e-30 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4282054 0.631 rs13081155 chr3:52732429 A/G cg10802521 chr3:52805072 NEK4 -0.29 -7.83 -0.3 2.11e-14 Cognitive function; BRCA cis rs769267 0.896 rs2315610 chr19:19597240 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.63 0.39 2.12e-24 Tonsillectomy; BRCA cis rs6582630 0.574 rs12146797 chr12:38436499 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.53 0.57 1.85e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.33 0.41 3.05e-27 Homoarginine levels; BRCA cis rs7772486 0.558 rs62435775 chr6:146136415 G/C cg05347473 chr6:146136440 FBXO30 0.61 12.03 0.43 3.38e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg11266682 chr4:10021025 SLC2A9 0.38 9.86 0.36 1.98e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.800 rs13107586 chr4:99028788 G/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs28615340 chr4:98896922 T/C cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.46e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.582 rs11922752 chr3:160600599 G/C cg03342759 chr3:160939853 NMD3 0.42 8.45 0.32 2.01e-16 Morning vs. evening chronotype; BRCA cis rs12497850 0.931 rs10780033 chr3:48891275 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.59 0.35 1.93e-20 Parkinson's disease; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.87 -18.4 -0.59 5.63e-61 Gut microbiome composition (summer); BRCA cis rs1005277 0.579 rs1614236 chr10:38502996 C/T cg25427524 chr10:38739819 LOC399744 -0.73 -17.57 -0.57 1.1e-56 Extrinsic epigenetic age acceleration; BRCA cis rs40363 0.671 rs4786425 chr16:3537650 A/G cg21433313 chr16:3507492 NAT15 -0.59 -8.1 -0.31 2.84e-15 Tuberculosis; BRCA cis rs12618769 0.597 rs4851142 chr2:99133611 A/C cg10123293 chr2:99228465 UNC50 0.41 8.05 0.3 3.94e-15 Bipolar disorder; BRCA cis rs2019137 0.560 rs4849179 chr2:113985170 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 0.66 13.58 0.47 4.27e-37 Lymphocyte counts; BRCA trans rs11039798 0.623 rs7294273 chr11:48705374 T/C cg15704280 chr7:45808275 SEPT13 0.62 10.32 0.38 3.42e-23 Axial length; BRCA trans rs7246760 0.867 rs8102257 chr19:9830795 C/T cg02900749 chr2:68251473 NA -0.5 -8.4 -0.32 2.8e-16 Pursuit maintenance gain; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg07092213 chr7:1199455 ZFAND2A -0.52 -11.6 -0.42 2.2e-28 Longevity;Endometriosis; BRCA cis rs13095912 1.000 rs9714158 chr3:185328780 C/T cg11274856 chr3:185301563 NA 0.36 8.84 0.33 9.31e-18 Systolic blood pressure; BRCA trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21582582 chr3:182698605 DCUN1D1 0.39 10.16 0.37 1.38e-22 Intelligence (multi-trait analysis); BRCA cis rs1451375 0.959 rs17133878 chr7:50620927 T/C cg18232548 chr7:50535776 DDC 0.39 9.55 0.35 2.79e-20 Malaria; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.95 -0.46 3.17e-34 Lymphocyte counts; BRCA cis rs651907 0.557 rs11720745 chr3:101441690 G/A cg12386194 chr3:101231763 SENP7 0.46 9.91 0.36 1.29e-21 Colorectal cancer; BRCA cis rs870825 0.616 rs28490461 chr4:185651638 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg10523679 chr1:76189770 ACADM 0.91 22.27 0.66 9.05e-82 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2841277 0.708 rs28454709 chr14:105405942 G/A cg14403583 chr14:105418241 AHNAK2 -0.38 -8.97 -0.33 3.29e-18 Rheumatoid arthritis; BRCA cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg06238570 chr21:40685208 BRWD1 -0.45 -8.93 -0.33 4.56e-18 Cognitive function; BRCA cis rs12477438 0.520 rs6542863 chr2:99725138 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.59e-84 Chronic sinus infection; BRCA cis rs7512552 0.839 rs11577843 chr1:150398258 A/G cg15654264 chr1:150340011 RPRD2 0.37 8.16 0.31 1.76e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg02734326 chr4:10020555 SLC2A9 0.39 8.39 0.32 3.04e-16 Bone mineral density; BRCA cis rs17270561 0.779 rs1165200 chr6:25875212 C/T cg17691542 chr6:26056736 HIST1H1C -0.62 -11.86 -0.42 1.77e-29 Iron status biomarkers; BRCA cis rs2153535 0.580 rs6921036 chr6:8455400 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.44 0.35 6.79e-20 Motion sickness; BRCA trans rs11098499 0.954 rs10006877 chr4:120242793 C/T cg25214090 chr10:38739885 LOC399744 0.52 11.65 0.42 1.41e-28 Corneal astigmatism; BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg19346786 chr7:2764209 NA -0.31 -8.88 -0.33 6.49e-18 Height; BRCA cis rs2011503 1.000 rs55927782 chr19:19642032 T/C cg15839431 chr19:19639596 YJEFN3 -0.43 -9.26 -0.34 3.07e-19 Bipolar disorder; BRCA cis rs10504229 0.683 rs56741275 chr8:58136108 C/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs11231017 0.514 rs953169 chr11:62083542 C/T cg23876832 chr11:62092739 NA -0.33 -8.52 -0.32 1.16e-16 HIV-1 viral setpoint; BRCA cis rs13191362 1.000 rs34931503 chr6:163003876 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.12 0.43 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4665809 1.000 rs10202478 chr2:26276049 T/C cg22920501 chr2:26401640 FAM59B -0.72 -12.35 -0.44 1.44e-31 Gut microbiome composition (summer); BRCA cis rs9486719 0.843 rs3849198 chr6:97036539 C/A cg06623918 chr6:96969491 KIAA0776 -0.76 -13.44 -0.47 1.88e-36 Migraine;Coronary artery disease; BRCA cis rs9291683 0.509 rs10939671 chr4:10050815 T/C cg00071950 chr4:10020882 SLC2A9 0.54 13.0 0.46 1.8e-34 Bone mineral density; BRCA cis rs6860806 0.661 rs1588263 chr5:131577158 T/C cg14196790 chr5:131705035 SLC22A5 0.33 8.58 0.32 7.09e-17 Breast cancer; BRCA cis rs637571 0.584 rs594689 chr11:65635559 G/A cg02427764 chr11:65769310 BANF1;EIF1AD -0.41 -8.07 -0.3 3.62e-15 Eosinophil percentage of white cells; BRCA cis rs6951245 1.000 rs76388414 chr7:1100694 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6752107 1.000 rs6431654 chr2:234161769 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.52 11.98 0.43 5.55e-30 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7737355 1.000 rs798412 chr5:130698474 C/A cg06307176 chr5:131281290 NA -0.46 -9.0 -0.34 2.54e-18 Life satisfaction; BRCA cis rs7772486 0.713 rs1986729 chr6:146194831 G/A cg05347473 chr6:146136440 FBXO30 0.44 8.65 0.32 4.19e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg05347473 chr6:146136440 FBXO30 0.4 8.11 0.31 2.64e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742234 0.541 rs7073849 chr10:43740474 G/C cg02780029 chr10:43622663 RET 0.35 7.94 0.3 9.1e-15 Hirschsprung disease; BRCA cis rs3770081 1.000 rs12620810 chr2:86391481 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -0.61 -8.3 -0.31 6.17e-16 Facial emotion recognition (sad faces); BRCA cis rs473651 0.901 rs563282 chr2:239329736 T/C cg18131467 chr2:239335373 ASB1 0.79 22.07 0.66 1.11e-80 Multiple system atrophy; BRCA cis rs7766436 0.885 rs13199041 chr6:22577718 A/G cg13666174 chr6:22585274 NA -0.49 -11.29 -0.41 4.4e-27 Coronary artery disease; BRCA cis rs4363385 0.669 rs2937264 chr1:153011026 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg03188948 chr7:1209495 NA 0.55 10.17 0.37 1.3e-22 Longevity;Endometriosis; BRCA cis rs6735179 0.603 rs10164788 chr2:1753379 G/A cg10160682 chr2:1713001 PXDN -0.36 -7.84 -0.3 1.88e-14 Response to antipsychotic treatment; BRCA cis rs68170813 0.641 rs12532953 chr7:106865920 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.47 -0.32 1.62e-16 Coronary artery disease; BRCA cis rs6570726 0.846 rs4896824 chr6:145927048 C/T cg23711669 chr6:146136114 FBXO30 0.69 16.31 0.54 3.09e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs922182 0.579 rs13329518 chr15:64241080 T/C cg24729988 chr15:64271149 DAPK2 0.49 10.65 0.39 1.69e-24 Blood protein levels; BRCA trans rs6089829 0.962 rs1116450 chr20:61658210 T/C cg23505145 chr19:12996616 KLF1 0.56 12.56 0.44 1.72e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs17270561 0.609 rs9366629 chr6:25741216 G/A cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -9.16 -0.34 7.19e-19 Alzheimer's disease; BRCA cis rs1322639 1.000 rs1322639 chr6:169587103 G/A cg03254818 chr6:169586852 NA -0.4 -8.56 -0.32 8.61e-17 Pulse pressure; BRCA cis rs7666738 0.830 rs60007031 chr4:98824753 G/C cg05340658 chr4:99064831 C4orf37 0.62 14.83 0.51 5.37e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.86 0.45 7.85e-34 Bipolar disorder; BRCA cis rs7267979 0.903 rs6115118 chr20:25246734 G/A cg08601574 chr20:25228251 PYGB 0.41 9.57 0.35 2.2e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7011049 1.000 rs72643574 chr8:53844501 G/C cg26025543 chr8:53854495 NA 0.55 9.64 0.36 1.25e-20 Systolic blood pressure; BRCA cis rs12887734 0.566 rs3742366 chr14:104198351 T/C cg08213375 chr14:104286397 PPP1R13B 0.5 10.69 0.39 1.24e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs1799949 1.000 rs8070085 chr17:41341984 C/T cg05368731 chr17:41323189 NBR1 -0.64 -17.73 -0.57 1.7e-57 Menopause (age at onset); BRCA cis rs9837602 0.872 rs35154249 chr3:99738230 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.61 10.53 0.38 5.15e-24 Breast cancer; BRCA cis rs7607369 0.526 rs4674322 chr2:219513782 C/T cg10223061 chr2:219282414 VIL1 -0.36 -8.57 -0.32 7.63e-17 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg18230493 chr5:56204884 C5orf35 -0.68 -13.41 -0.47 2.57e-36 Initial pursuit acceleration; BRCA cis rs765787 0.530 rs2413785 chr15:45530381 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.23 0.31 1.02e-15 Uric acid levels; BRCA cis rs2075371 1.000 rs2544211 chr7:133973230 A/G cg11752832 chr7:134001865 SLC35B4 0.51 13.12 0.46 5.53e-35 Mean platelet volume; BRCA cis rs17125944 0.505 rs28568967 chr14:53223060 A/G cg13660082 chr14:53194042 PSMC6 -0.57 -8.73 -0.33 2.14e-17 Alzheimer's disease (late onset); BRCA trans rs11098499 0.863 rs3733525 chr4:120447048 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.28 0.31 7.45e-16 Corneal astigmatism; BRCA cis rs6540559 1.000 rs2235373 chr1:209963803 G/A cg22029157 chr1:209979665 IRF6 0.56 12.49 0.44 3.54e-32 Cleft lip with or without cleft palate; BRCA cis rs910316 0.967 rs175498 chr14:75536369 G/A cg11812906 chr14:75593930 NEK9 -0.61 -13.87 -0.48 1.91e-38 Height; BRCA cis rs1129187 0.902 rs6907751 chr6:42944850 C/T cg27588902 chr6:42928151 GNMT -0.3 -10.05 -0.37 3.77e-22 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs2204008 0.840 rs3892363 chr12:38479487 G/A cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Bladder cancer; BRCA cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg09184832 chr6:79620586 NA -0.51 -11.28 -0.41 4.77e-27 Intelligence (multi-trait analysis); BRCA cis rs11677370 0.603 rs11675498 chr2:3850943 G/T cg17052675 chr2:3827356 NA -0.53 -12.68 -0.45 5.06e-33 Type 2 diabetes; BRCA cis rs2075371 0.865 rs2544172 chr7:133931338 T/C cg02659138 chr7:134003124 SLC35B4 0.33 10.05 0.37 3.59e-22 Mean platelet volume; BRCA cis rs4363385 0.747 rs2339493 chr1:152975277 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA trans rs10028773 0.515 rs9994651 chr4:120587803 C/T cg25214090 chr10:38739885 LOC399744 0.41 9.19 0.34 5.33e-19 Educational attainment; BRCA cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg20607798 chr8:58055168 NA 0.47 8.02 0.3 5.03e-15 Developmental language disorder (linguistic errors); BRCA trans rs6951245 0.935 rs112554101 chr7:1065535 A/G cg13565492 chr6:43139072 SRF -0.56 -8.33 -0.31 5.12e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9649213 0.593 rs2240349 chr7:97984663 C/T cg24562669 chr7:97807699 LMTK2 0.46 12.25 0.44 3.81e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs8114671 0.562 rs6087649 chr20:33510662 A/G cg07148914 chr20:33460835 GGT7 0.38 8.57 0.32 7.57e-17 Height; BRCA cis rs3087591 0.887 rs2905796 chr17:29537586 G/A cg24425628 chr17:29625626 OMG;NF1 0.47 9.53 0.35 3.18e-20 Hip circumference; BRCA cis rs4319547 0.760 rs61954973 chr12:123074168 T/C cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.94 -0.37 9.99e-22 Body mass index; BRCA cis rs2011503 1.000 rs2965184 chr19:19545428 C/T cg11584989 chr19:19387371 SF4 -0.62 -13.38 -0.47 3.41e-36 Bipolar disorder; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg07256732 chr16:621771 PIGQ -0.35 -9.33 -0.35 1.75e-19 Height; BRCA trans rs9858542 1.000 rs11130213 chr3:49712297 C/T cg21659725 chr3:3221576 CRBN -0.47 -10.03 -0.37 4.52e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4975709 0.589 rs1466607 chr5:1864856 A/G cg01114163 chr5:1856713 NA -0.36 -7.94 -0.3 9.07e-15 Cardiovascular disease risk factors; BRCA cis rs10751667 1.000 rs4074232 chr11:977682 C/G ch.11.42038R chr11:967971 AP2A2 0.57 18.79 0.6 4.8e-63 Alzheimer's disease (late onset); BRCA cis rs7267979 0.932 rs449370 chr20:25451180 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.27 -0.31 7.94e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12549902 0.871 rs4736819 chr8:41509915 C/T cg21772509 chr8:41503840 NKX6-3 0.45 10.68 0.39 1.32e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index;Insulin levels adjusted for BMI;Type 2 diabetes; BRCA cis rs9640161 0.830 rs17173681 chr7:150059414 A/G cg12556325 chr7:150026731 C7orf29;LRRC61 0.54 12.57 0.45 1.48e-32 Blood protein levels;Circulating chemerin levels; BRCA cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg25173405 chr17:45401733 C17orf57 -0.51 -10.66 -0.39 1.62e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs514406 0.861 rs35517489 chr1:53304062 G/C cg08859206 chr1:53392774 SCP2 -0.48 -10.35 -0.38 2.6e-23 Monocyte count; BRCA cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg06636001 chr8:8085503 FLJ10661 0.65 14.69 0.5 2.71e-42 Mood instability; BRCA cis rs2032447 0.832 rs10425 chr6:26056549 A/G cg03264133 chr6:25882463 NA -0.49 -10.24 -0.38 7.06e-23 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.546 rs2056159 chr12:39270417 C/G cg26384229 chr12:38710491 ALG10B 0.66 14.34 0.49 1.26e-40 Morning vs. evening chronotype; BRCA cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg21644426 chr2:191273491 MFSD6 0.45 11.13 0.4 1.94e-26 Pulse pressure; BRCA trans rs10506458 0.688 rs60936040 chr12:63416461 G/A cg22491629 chr6:157744540 C6orf35 -0.45 -9.38 -0.35 1.18e-19 Hemostatic factors and hematological phenotypes; BRCA cis rs6582630 0.585 rs12422588 chr12:38478675 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.84 -0.36 2.21e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg00166722 chr3:10149974 C3orf24 0.65 13.07 0.46 8.76e-35 Alzheimer's disease; BRCA cis rs3862260 0.509 rs3795662 chr1:120165135 G/T cg16322792 chr1:120165303 ZNF697 0.58 15.43 0.52 6.54e-46 Systemic lupus erythematosus; BRCA cis rs2479724 0.840 rs10498752 chr6:41768510 T/C cg17623882 chr6:41773611 USP49 0.37 9.92 0.37 1.15e-21 Menarche (age at onset); BRCA cis rs10927875 0.518 rs732286 chr1:16344360 A/G cg22431228 chr1:16359049 CLCNKA -0.44 -9.91 -0.37 1.19e-21 Dilated cardiomyopathy; BRCA cis rs2836974 0.568 rs4816620 chr21:40613786 A/G cg06238570 chr21:40685208 BRWD1 -0.42 -8.49 -0.32 1.41e-16 Cognitive function; BRCA cis rs3749237 0.964 rs34522271 chr3:49808517 A/G cg03060546 chr3:49711283 APEH 0.5 10.71 0.39 9.52e-25 Resting heart rate; BRCA cis rs66569888 0.789 rs17213078 chr2:106734065 G/A cg15412446 chr2:106886593 NA -0.49 -9.03 -0.34 2.05e-18 Facial morphology (factor 23); BRCA cis rs4819052 0.851 rs3673 chr21:46681775 C/T cg11663144 chr21:46675770 NA -0.55 -12.76 -0.45 2.26e-33 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7666738 0.830 rs28451101 chr4:99001190 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.74 0.39 7.86e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs11051970 0.636 rs2733703 chr12:32561794 C/T cg24626660 chr12:32551988 NA 0.31 9.18 0.34 5.82e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs7917772 0.582 rs4919663 chr10:104363293 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.32 0.49 1.48e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs495337 0.965 rs4810999 chr20:48580969 A/T cg17835207 chr20:48524531 SPATA2 -0.61 -14.08 -0.49 2.15e-39 Psoriasis; BRCA cis rs1401999 0.606 rs939335 chr3:183745663 A/G cg20387954 chr3:183756860 HTR3D 0.4 9.08 0.34 1.39e-18 Anterior chamber depth; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg24829409 chr8:58192753 C8orf71 -0.47 -8.1 -0.31 2.77e-15 Developmental language disorder (linguistic errors); BRCA trans rs2727020 0.590 rs7949936 chr11:49378902 G/A cg11707556 chr5:10655725 ANKRD33B -0.41 -8.48 -0.32 1.55e-16 Coronary artery disease; BRCA cis rs2842992 0.724 rs9365097 chr6:160211259 G/A cg19482086 chr6:160211437 TCP1;MRPL18 0.74 21.77 0.65 5.24e-79 Age-related macular degeneration (geographic atrophy); BRCA cis rs875971 0.825 rs4587224 chr7:65736182 G/A cg18876405 chr7:65276391 NA -0.51 -11.75 -0.42 5.48e-29 Aortic root size; BRCA cis rs7552404 0.883 rs77773255 chr1:76217193 G/A cg22875332 chr1:76189707 ACADM 0.69 14.84 0.51 5.09e-43 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs634534 0.622 rs552130 chr11:65732800 T/C cg17985854 chr11:65770987 BANF1;EIF1AD 0.36 8.7 0.33 2.84e-17 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs826838 0.967 rs1719854 chr12:39127707 G/A cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs7246657 0.722 rs8100646 chr19:38107943 T/C cg18154014 chr19:37997991 ZNF793 0.5 9.55 0.35 2.6e-20 Coronary artery calcification; BRCA cis rs4665809 1.000 rs3910272 chr2:26287842 T/A cg26314531 chr2:26401878 FAM59B -0.79 -12.64 -0.45 7.76e-33 Gut microbiome composition (summer); BRCA trans rs637571 0.522 rs1786175 chr11:65754808 G/A cg17712092 chr4:129076599 LARP1B 0.55 13.37 0.47 4.05e-36 Eosinophil percentage of white cells; BRCA cis rs7917772 0.582 rs4917975 chr10:104358407 C/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.24 0.49 3.5e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs1577917 1.000 rs10498958 chr6:86649705 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.36 8.73 0.33 2.29e-17 Response to antipsychotic treatment; BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA trans rs9858542 0.951 rs1800668 chr3:49395757 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.03 -0.34 1.96e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4148883 0.629 rs10009145 chr4:100047929 G/A cg13256891 chr4:100009986 ADH5 0.38 8.11 0.31 2.55e-15 Alcohol dependence; BRCA cis rs11098499 0.909 rs7681978 chr4:120383775 T/C cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs6964587 0.732 rs12539523 chr7:91710836 G/A cg01689657 chr7:91764605 CYP51A1 0.24 8.55 0.32 9.28e-17 Breast cancer; BRCA cis rs13191362 1.000 rs67646369 chr6:163003233 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.33 0.31 4.81e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6570726 0.791 rs374478 chr6:145840022 C/T cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs2153535 0.580 rs1577472 chr6:8486215 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.64 0.36 1.24e-20 Motion sickness; BRCA cis rs3617 0.573 rs6795646 chr3:52922621 C/T cg11645453 chr3:52864694 ITIH4 -0.36 -9.72 -0.36 6.65e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs11123170 0.640 rs2863240 chr2:113970116 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.49 -8.52 -0.32 1.16e-16 Renal function-related traits (BUN); BRCA cis rs600231 0.623 rs587080 chr11:65253800 A/C cg01292856 chr11:65242576 NA 0.33 8.19 0.31 1.42e-15 Bone mineral density; BRCA cis rs778371 0.676 rs2293780 chr2:233635213 T/C cg08000102 chr2:233561755 GIGYF2 0.85 21.2 0.64 6.23e-76 Schizophrenia; BRCA cis rs736801 0.808 rs2248116 chr5:131804347 C/A cg07395648 chr5:131743802 NA 0.37 8.67 0.32 3.49e-17 Breast cancer;Mosquito bite size; BRCA cis rs611744 0.550 rs1448154 chr8:109281053 T/C cg21045802 chr8:109455806 TTC35 0.34 7.84 0.3 1.93e-14 Dupuytren's disease; BRCA cis rs7552404 0.731 rs11161857 chr1:76370228 G/C cg03433033 chr1:76189801 ACADM 0.69 12.83 0.45 1.1e-33 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs1493916 0.905 rs9956315 chr18:31405546 G/C cg15819921 chr19:927150 ARID3A -0.52 -10.14 -0.37 1.63e-22 Life satisfaction; BRCA cis rs7666738 0.830 rs6818045 chr4:99049374 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.791 rs10010438 chr4:99022177 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs13064411 0.696 rs1552432 chr3:113225660 G/C cg18753928 chr3:113234510 CCDC52 -0.58 -12.31 -0.44 2.2e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs12541635 0.966 rs6469023 chr8:106989558 T/C cg10147462 chr8:107024639 NA 0.39 10.31 0.38 3.69e-23 Age of smoking initiation; BRCA cis rs9649213 0.574 rs12873 chr7:97922773 T/C cg21770322 chr7:97807741 LMTK2 0.42 11.34 0.41 2.69e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg00825309 chr19:58991885 ZNF446 -0.58 -12.62 -0.45 8.94e-33 Uric acid clearance; BRCA cis rs1005277 0.541 rs2505193 chr10:38394638 G/C cg00409905 chr10:38381863 ZNF37A -0.52 -11.13 -0.4 1.98e-26 Extrinsic epigenetic age acceleration; BRCA cis rs514406 0.668 rs520281 chr1:53365235 G/C cg24675658 chr1:53192096 ZYG11B -0.67 -15.03 -0.51 5.91e-44 Monocyte count; BRCA cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.23 -0.41 7.77e-27 Schizophrenia; BRCA cis rs3749237 0.964 rs11717463 chr3:49808981 C/T cg03060546 chr3:49711283 APEH 0.52 10.8 0.39 4.28e-25 Resting heart rate; BRCA cis rs3741404 0.791 rs7102177 chr11:63909228 T/C cg05016508 chr11:63871570 FLRT1;MACROD1 0.37 8.0 0.3 5.67e-15 Platelet count; BRCA cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -10.26 -0.38 5.58e-23 Mean corpuscular volume; BRCA cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg23711669 chr6:146136114 FBXO30 0.84 20.2 0.62 1.5e-70 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.901 rs4706077 chr6:79548845 G/A cg18132916 chr6:79620363 NA -0.46 -10.68 -0.39 1.33e-24 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.967 rs2287062 chr2:10743191 G/A cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs6952808 0.823 rs58222895 chr7:1885064 G/A cg03354898 chr7:1950403 MAD1L1 -0.44 -9.24 -0.34 3.74e-19 Bipolar disorder and schizophrenia; BRCA cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.5 -11.05 -0.4 4.27e-26 IgG glycosylation; BRCA cis rs6763687 0.687 rs6762040 chr3:171803713 C/T cg16233210 chr3:171778391 FNDC3B 0.35 7.92 0.3 1.06e-14 Red cell distribution width; BRCA cis rs16958440 0.867 rs3809966 chr18:44677627 C/T cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs77106637 0.556 rs7123876 chr11:72444583 T/C cg04827223 chr11:72435913 ARAP1 -0.67 -15.55 -0.52 1.84e-46 Type 2 diabetes; BRCA cis rs2180341 0.782 rs6569490 chr6:127729615 C/T cg27446573 chr6:127587934 RNF146 0.67 15.13 0.51 2.02e-44 Breast cancer; BRCA cis rs10128251 0.746 rs9424194 chr10:5724073 A/G cg24097872 chr10:5724021 NA 0.59 13.26 0.46 1.29e-35 Childhood ear infection; BRCA cis rs6546537 0.824 rs13011186 chr2:69778558 C/T cg10773587 chr2:69614142 GFPT1 -0.4 -8.64 -0.32 4.44e-17 Serum thyroid-stimulating hormone levels; BRCA cis rs11676348 0.818 rs7426289 chr2:218966315 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.39 -8.08 -0.3 3.22e-15 Ulcerative colitis; BRCA cis rs2115630 0.875 rs8039472 chr15:85361644 A/G cg12863693 chr15:85201151 NMB -0.39 -8.97 -0.33 3.35e-18 P wave terminal force; BRCA cis rs873946 0.557 rs34854637 chr10:134582962 A/G cg13271783 chr10:134563150 INPP5A -0.49 -9.87 -0.36 1.69e-21 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10504229 0.906 rs903718 chr8:58167726 A/G cg24829409 chr8:58192753 C8orf71 -0.55 -11.6 -0.42 2.34e-28 Developmental language disorder (linguistic errors); BRCA cis rs7944584 0.563 rs61895112 chr11:47560433 T/C cg20307385 chr11:47447363 PSMC3 0.75 16.59 0.55 1.18e-51 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs61931739 0.500 rs11053193 chr12:34438838 G/T cg26384229 chr12:38710491 ALG10B 0.75 16.67 0.55 4.32e-52 Morning vs. evening chronotype; BRCA cis rs2439831 0.850 rs10163054 chr15:44047638 G/T cg10011062 chr15:43941034 CATSPER2 -0.55 -8.09 -0.3 3.05e-15 Lung cancer in ever smokers; BRCA trans rs6598955 0.671 rs11579354 chr1:26604071 T/G cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs67478160 0.625 rs7141473 chr14:104316055 A/C cg08213375 chr14:104286397 PPP1R13B -0.64 -17.71 -0.57 2.25e-57 Schizophrenia; BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg14573099 chr2:101761014 TBC1D8 -0.33 -8.23 -0.31 1.08e-15 Mosquito bite size; BRCA cis rs2153535 0.580 rs6938071 chr6:8464845 A/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2070488 0.775 rs7374458 chr3:38531211 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.65 17.03 0.56 6.65e-54 Electrocardiographic conduction measures; BRCA cis rs701145 0.556 rs355771 chr3:154039385 G/C cg16511985 chr3:153974050 SGEF 0.46 10.32 0.38 3.24e-23 Coronary artery disease; BRCA cis rs921968 0.541 rs3755042 chr2:219317248 T/C cg10223061 chr2:219282414 VIL1 0.29 8.39 0.32 3.07e-16 Mean corpuscular hemoglobin concentration; BRCA cis rs6121246 0.909 rs6087778 chr20:30354142 G/A cg21427119 chr20:30132790 HM13 -0.41 -8.71 -0.33 2.68e-17 Mean corpuscular hemoglobin; BRCA cis rs6066835 1.000 rs6095244 chr20:47318774 T/C cg18078177 chr20:47281410 PREX1 0.69 8.21 0.31 1.25e-15 Multiple myeloma; BRCA cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg10845886 chr2:3471009 TTC15 -0.56 -12.55 -0.44 1.89e-32 Neurofibrillary tangles; BRCA trans rs11039798 0.764 rs1121450 chr11:48897476 C/T cg15704280 chr7:45808275 SEPT13 0.59 8.85 0.33 8.8e-18 Axial length; BRCA cis rs7267979 1.000 rs4815411 chr20:25350223 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.39 -0.31 3.15e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9473147 0.543 rs1872505 chr6:47480975 C/G cg12968598 chr6:47444699 CD2AP 0.44 9.59 0.35 1.93e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs6964587 0.967 rs2282969 chr7:91583772 T/C cg17063962 chr7:91808500 NA -0.52 -12.19 -0.43 7.28e-31 Breast cancer; BRCA cis rs2075371 0.830 rs12669960 chr7:133931782 A/G cg11752832 chr7:134001865 SLC35B4 0.48 10.95 0.4 1.12e-25 Mean platelet volume; BRCA cis rs11190604 1.000 rs1800662 chr10:102289078 C/A cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg19010396 chr19:19431384 KIAA0892;SF4 0.48 9.86 0.36 1.91e-21 Tonsillectomy; BRCA cis rs739401 0.527 rs418832 chr11:3072236 C/T cg25174290 chr11:3078921 CARS 0.45 13.42 0.47 2.26e-36 Longevity; BRCA cis rs4566357 0.615 rs12474622 chr2:227912793 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -9.44 -0.35 6.61e-20 Coronary artery disease; BRCA cis rs4713118 0.868 rs760587 chr6:27740300 C/A cg20933634 chr6:27740509 NA 0.47 8.87 0.33 7.05e-18 Parkinson's disease; BRCA cis rs4561483 0.801 rs33623 chr16:12007435 A/G cg08843971 chr16:11963173 GSPT1 0.54 12.39 0.44 9.71e-32 Testicular germ cell tumor; BRCA cis rs13136331 0.759 rs6855426 chr4:88646335 A/G cg22416721 chr4:88570574 DMP1 -0.45 -10.89 -0.4 1.88e-25 Sitting height ratio; BRCA cis rs7100689 0.646 rs1340382 chr10:82096997 G/C cg01528321 chr10:82214614 TSPAN14 0.82 17.4 0.57 8.14e-56 Post bronchodilator FEV1; BRCA cis rs12612619 0.732 rs1866654 chr2:27263122 A/G cg00617064 chr2:27272375 NA -0.33 -8.54 -0.32 9.66e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg00814883 chr7:100076585 TSC22D4 -0.48 -9.96 -0.37 7.73e-22 Platelet count; BRCA cis rs2197308 0.765 rs10880643 chr12:37926452 C/T cg26384229 chr12:38710491 ALG10B -0.58 -13.43 -0.47 2.13e-36 Morning vs. evening chronotype; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19717773 chr7:2847554 GNA12 -0.42 -8.0 -0.3 6.03e-15 Height; BRCA cis rs1883415 0.534 rs2817205 chr6:24477134 G/A cg20631270 chr6:24437470 GPLD1 0.4 8.11 0.31 2.54e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7119038 0.509 rs10892257 chr11:118579327 G/A cg19308663 chr11:118741387 NA 0.38 8.53 0.32 1.1e-16 Sjögren's syndrome; BRCA cis rs1707322 1.000 rs1613296 chr1:46546852 A/C cg06784218 chr1:46089804 CCDC17 -0.39 -9.08 -0.34 1.34e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg10802521 chr3:52805072 NEK4 -0.31 -7.87 -0.3 1.56e-14 Bipolar disorder; BRCA cis rs875971 0.862 rs6959268 chr7:65812966 G/A cg11764359 chr7:65958608 NA -0.77 -17.73 -0.57 1.71e-57 Aortic root size; BRCA trans rs3960554 0.808 rs13438599 chr7:75768022 G/A cg19862616 chr7:65841803 NCRNA00174 0.59 12.13 0.43 1.28e-30 Eotaxin levels; BRCA cis rs10267417 0.603 rs6976553 chr7:19869113 T/C cg07541023 chr7:19748670 TWISTNB 0.51 9.19 0.34 5.25e-19 Night sleep phenotypes; BRCA cis rs6912958 0.559 rs395358 chr6:88057924 T/C cg08069147 chr6:88032118 GJB7;C6orf162 0.56 11.83 0.42 2.35e-29 Monocyte percentage of white cells; BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.52 8.49 0.32 1.41e-16 Renal function-related traits (BUN); BRCA cis rs3845702 0.736 rs72958863 chr2:180808144 C/T cg01881094 chr2:180872142 CWC22 1.03 16.59 0.55 1.19e-51 Schizophrenia; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -8.93 -0.33 4.67e-18 Alzheimer's disease; BRCA cis rs2882667 0.537 rs11743534 chr5:138409007 G/T cg04439458 chr5:138467593 SIL1 -0.33 -8.99 -0.34 2.74e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs12497850 0.897 rs9884022 chr3:48956862 G/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.57 0.35 2.37e-20 Parkinson's disease; BRCA cis rs7267979 1.000 rs2482919 chr20:25299756 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.58 -0.32 7.02e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs79057730 0.599 rs112891948 chr7:816059 C/T cg05729249 chr7:766119 PRKAR1B;HEATR2 0.79 10.93 0.4 1.35e-25 Initial pursuit acceleration; BRCA cis rs3858526 0.959 rs11039723 chr11:5956002 G/C cg25319279 chr11:5960081 NA -0.43 -8.02 -0.3 4.89e-15 DNA methylation (variation); BRCA trans rs11039798 0.588 rs7116858 chr11:48543920 C/A cg15704280 chr7:45808275 SEPT13 0.53 9.04 0.34 1.84e-18 Axial length; BRCA cis rs6088580 0.634 rs4911422 chr20:32999345 T/C cg08999081 chr20:33150536 PIGU -0.47 -12.95 -0.46 3.13e-34 Glomerular filtration rate (creatinine); BRCA cis rs1008375 0.932 rs9884565 chr4:17655096 A/G cg02297831 chr4:17616191 MED28 0.36 8.4 0.32 2.97e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.500 rs6416261 chr12:34540377 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.55 0.47 5.69e-37 Morning vs. evening chronotype; BRCA cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg04511125 chr2:88470314 THNSL2 0.94 13.18 0.46 2.99e-35 Plasma clusterin levels; BRCA cis rs7264396 0.677 rs6060553 chr20:34267386 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.48 -0.5 2.76e-41 Total cholesterol levels; BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 21.96 0.66 4.85e-80 Platelet count; BRCA trans rs4596713 0.538 rs10114369 chr9:71799697 T/A cg16512924 chr15:28394682 HERC2 0.45 10.67 0.39 1.44e-24 Headache; BRCA cis rs6121246 0.559 rs6058465 chr20:30397691 G/A cg13852791 chr20:30311386 BCL2L1 0.95 23.06 0.67 4.46e-86 Mean corpuscular hemoglobin; BRCA cis rs7799006 1.000 rs7787274 chr7:2275993 G/A cg08027265 chr7:2291960 NA -0.42 -10.65 -0.39 1.67e-24 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs992157 0.585 rs62182795 chr2:219100202 C/T cg00012203 chr2:219082015 ARPC2 -0.57 -12.05 -0.43 2.87e-30 Colorectal cancer; BRCA cis rs2463822 1.000 rs118049526 chr11:62107508 C/T cg06239285 chr11:62104954 ASRGL1 -0.7 -9.73 -0.36 5.89e-21 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs7267979 1.000 rs2259928 chr20:25281834 G/C cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.63e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs780096 0.526 rs1406295 chr2:27689700 A/G cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg11764359 chr7:65958608 NA -0.66 -14.47 -0.5 2.97e-41 Aortic root size; BRCA cis rs2289583 0.503 rs113742359 chr15:75261643 A/G cg10253484 chr15:75165896 SCAMP2 0.42 8.36 0.31 3.91e-16 Systemic lupus erythematosus; BRCA trans rs4698048 0.510 rs12509714 chr4:10107091 C/G cg26043149 chr18:55253948 FECH 0.44 9.98 0.37 6.58e-22 Skin aging (microtopography measurement); BRCA cis rs2425143 1.000 rs6058304 chr20:34299851 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.0 -0.34 2.6e-18 Blood protein levels; BRCA cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.62 14.24 0.49 3.48e-40 Colorectal cancer; BRCA cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.9 0.33 5.78e-18 Personality dimensions; BRCA cis rs2645694 0.532 rs2645706 chr4:77829606 A/C cg10057126 chr4:77819792 ANKRD56 0.63 14.73 0.5 1.76e-42 Emphysema distribution in smoking; BRCA cis rs10504229 0.683 rs11785260 chr8:58132906 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg06046430 chr4:77819534 ANKRD56 0.56 12.2 0.43 6.54e-31 Emphysema distribution in smoking; BRCA cis rs7772486 0.790 rs4280983 chr6:146280790 G/C cg23711669 chr6:146136114 FBXO30 -0.79 -18.02 -0.58 4.97e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 0.720 rs7795656 chr7:99950297 A/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.02 -0.46 1.47e-34 Platelet count; BRCA cis rs7918232 0.567 rs11015463 chr10:27319258 A/G cg14240646 chr10:27532245 ACBD5 -0.48 -8.29 -0.31 6.63e-16 Breast cancer; BRCA cis rs7586879 1.000 rs7586879 chr2:25116977 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.22 0.34 4.12e-19 Body mass index; BRCA cis rs897984 0.721 rs28360557 chr16:30983260 A/C cg02466173 chr16:30829666 NA 0.49 11.14 0.4 1.89e-26 Dementia with Lewy bodies; BRCA cis rs769267 1.000 rs7247309 chr19:19439631 A/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.93 -0.37 1.07e-21 Tonsillectomy; BRCA trans rs1391576 1 rs1391576 chr11:51394932 C/T cg15704280 chr7:45808275 SEPT13 0.62 8.53 0.32 1.09e-16 Body mass index; BRCA cis rs6840258 0.941 rs6854749 chr4:87968798 A/T cg08197287 chr4:87952173 AFF1 -0.44 -8.83 -0.33 9.67e-18 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs7945705 0.902 rs1560569 chr11:8939887 C/T cg21881798 chr11:8931708 C11orf17;ST5 -0.57 -12.94 -0.46 3.44e-34 Hemoglobin concentration; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg04944784 chr2:26401820 FAM59B -1.0 -16.8 -0.55 9.74e-53 Gut microbiome composition (summer); BRCA cis rs17401966 0.931 rs12409754 chr1:10457540 T/C cg03954927 chr1:10346856 KIF1B 0.47 14.09 0.49 1.77e-39 Hepatocellular carcinoma; BRCA trans rs1005277 0.579 rs1740737 chr10:38499365 G/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.51 -0.47 9.57e-37 Extrinsic epigenetic age acceleration; BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13012494 chr21:47604986 C21orf56 0.43 9.06 0.34 1.53e-18 Testicular germ cell tumor; BRCA cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg19077165 chr18:44547161 KATNAL2 -0.58 -13.02 -0.46 1.57e-34 Personality dimensions; BRCA cis rs12367572 0.663 rs1224436 chr12:45400397 C/T cg04608330 chr12:45269318 NELL2 -0.36 -7.92 -0.3 1.06e-14 Gut microbiome composition (summer); BRCA cis rs4478858 0.735 rs7523438 chr1:31788313 C/T cg00250761 chr1:31883323 NA 0.32 8.37 0.31 3.57e-16 Alcohol dependence; BRCA cis rs1635 0.655 rs2281041 chr6:28303845 G/C cg15743358 chr6:28303923 ZNF323 -0.75 -8.56 -0.32 8.52e-17 Schizophrenia; BRCA cis rs8031584 0.505 rs2959036 chr15:31219742 T/G cg14829155 chr15:31115871 NA 0.42 9.99 0.37 6.31e-22 Huntington's disease progression; BRCA cis rs7267979 1.000 rs453329 chr20:25440593 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.18 0.34 5.8e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs698813 0.604 rs12712916 chr2:44482099 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.74 0.33 2.08e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.53 8.16 0.31 1.83e-15 Renal function-related traits (BUN); BRCA cis rs6089584 0.893 rs6089306 chr20:60574868 G/A cg06108461 chr20:60628389 TAF4 -0.79 -17.05 -0.56 5.4e-54 Body mass index; BRCA cis rs8062405 0.929 rs11864750 chr16:28875204 A/T cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2251381 0.606 rs8129515 chr21:30520167 C/G cg08807101 chr21:30365312 RNF160 0.6 12.66 0.45 6.34e-33 Selective IgA deficiency; BRCA cis rs11758351 0.866 rs77205516 chr6:26205356 T/A cg01420254 chr6:26195488 NA 0.56 8.65 0.32 4.11e-17 Gout;Renal underexcretion gout; BRCA cis rs9399135 0.967 rs11755229 chr6:135369913 A/G cg24558204 chr6:135376177 HBS1L 0.45 12.26 0.44 3.46e-31 Red blood cell count; BRCA cis rs12497850 0.931 rs7430501 chr3:48890119 C/T cg07636037 chr3:49044803 WDR6 0.98 29.32 0.76 2.17e-120 Parkinson's disease; BRCA cis rs10504229 0.861 rs114700910 chr8:58170642 C/T cg14926445 chr8:58193284 C8orf71 -0.44 -8.25 -0.31 8.87e-16 Developmental language disorder (linguistic errors); BRCA cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22455342 chr2:225449267 CUL3 0.65 17.08 0.56 3.54e-54 IgE levels in asthmatics (D.p. specific); BRCA cis rs6951245 0.554 rs76243429 chr7:1152543 C/T cg24642844 chr7:1081250 C7orf50 -0.59 -12.09 -0.43 1.88e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9649213 0.593 rs35983874 chr7:97916461 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.59 -0.32 6.49e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1843834 0.505 rs7585047 chr2:225373897 C/T cg12698349 chr2:225449008 CUL3 0.61 13.05 0.46 1.14e-34 IgE levels in asthmatics (D.p. specific); BRCA cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 9.05 0.34 1.69e-18 Bipolar disorder; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.32 -0.47 6.49e-36 Lymphocyte counts; BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg13397359 chr6:42928475 GNMT 0.68 16.39 0.54 1.23e-50 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg00990874 chr7:1149470 C7orf50 -0.6 -10.33 -0.38 3.05e-23 Bronchopulmonary dysplasia; BRCA cis rs1994135 0.565 rs11052767 chr12:33731194 A/G cg06521331 chr12:34319734 NA -0.49 -9.41 -0.35 8.53e-20 Resting heart rate; BRCA cis rs28374715 0.662 rs521890 chr15:41473143 C/T cg18705301 chr15:41695430 NDUFAF1 -0.78 -16.64 -0.55 6.45e-52 Ulcerative colitis; BRCA cis rs589448 0.934 rs554591 chr12:69753847 T/C cg20891283 chr12:69753455 YEATS4 0.84 28.4 0.75 2.24e-115 Cerebrospinal fluid biomarker levels; BRCA trans rs7615952 0.688 rs12638240 chr3:125541238 G/A cg07211511 chr3:129823064 LOC729375 -0.77 -14.86 -0.51 4.12e-43 Blood pressure (smoking interaction); BRCA cis rs6714710 0.603 rs6738389 chr2:98386731 A/G cg26665480 chr2:98280029 ACTR1B 0.61 14.05 0.49 2.86e-39 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs16858210 0.529 rs10937154 chr3:183569489 C/T cg25686905 chr3:183603175 PARL -0.39 -8.39 -0.31 3.14e-16 Menopause (age at onset); BRCA cis rs921968 0.541 rs667251 chr2:219384384 C/G cg10223061 chr2:219282414 VIL1 -0.27 -8.16 -0.31 1.85e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs3862260 0.509 rs10802124 chr1:120164252 G/A cg16322792 chr1:120165303 ZNF697 0.58 15.43 0.52 6.54e-46 Systemic lupus erythematosus; BRCA cis rs7945705 0.967 rs10840141 chr11:8902218 T/C cg21881798 chr11:8931708 C11orf17;ST5 0.58 12.91 0.45 4.89e-34 Hemoglobin concentration; BRCA cis rs7666738 0.830 rs4699591 chr4:98974171 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.546 rs4425043 chr2:27733452 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.26 -0.31 8.35e-16 Total body bone mineral density; BRCA cis rs11098499 0.743 rs11098501 chr4:120252017 T/G cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs2243480 0.908 rs55876148 chr7:65379800 G/A cg18252515 chr7:66147081 NA -0.87 -12.09 -0.43 1.84e-30 Diabetic kidney disease; BRCA cis rs4363385 0.693 rs689008 chr1:153047100 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.04 -0.3 4.26e-15 Inflammatory skin disease; BRCA cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg14983838 chr19:29218262 NA 0.54 10.08 0.37 2.78e-22 Methadone dose in opioid dependence; BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.52 8.1 0.31 2.74e-15 Renal function-related traits (BUN); BRCA cis rs6762477 0.748 rs3755831 chr3:50228767 G/T cg14019146 chr3:50243930 SLC38A3 0.39 9.44 0.35 6.68e-20 Menarche (age at onset); BRCA cis rs1506636 0.962 rs629474 chr7:123399684 C/T cg03229431 chr7:123269106 ASB15 0.61 13.78 0.48 4.97e-38 Plateletcrit;Platelet count; BRCA cis rs2153535 0.580 rs9505467 chr6:8520219 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.27e-41 Motion sickness; BRCA cis rs4363385 0.747 rs10494285 chr1:152982285 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.82e-16 Inflammatory skin disease; BRCA trans rs3733585 0.648 rs28513781 chr4:9959334 G/C cg26043149 chr18:55253948 FECH -0.38 -8.28 -0.31 7.15e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1669338 0.588 rs3864050 chr3:3186769 T/C cg16797762 chr3:3221439 CRBN -0.69 -10.49 -0.38 7.27e-24 White matter integrity; BRCA cis rs1182196 0.502 rs757786 chr7:2836019 C/T cg19717773 chr7:2847554 GNA12 -0.5 -11.83 -0.42 2.41e-29 Plateletcrit; BRCA cis rs881375 1.000 rs10818480 chr9:123643170 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.2 0.41 1.02e-26 Rheumatoid arthritis; BRCA cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs13191362 1.000 rs4260737 chr6:163137746 T/C cg06582575 chr6:163149167 PACRG;PARK2 1.02 15.04 0.51 5.48e-44 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17095355 1.000 rs17095350 chr10:111701708 T/C cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.25 -0.38 6.11e-23 Biliary atresia; BRCA cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg14036092 chr11:66035641 RAB1B 0.4 10.76 0.39 6.55e-25 Gout; BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg02733842 chr7:1102375 C7orf50 -0.61 -11.52 -0.41 4.99e-28 Bronchopulmonary dysplasia; BRCA cis rs1568889 0.592 rs17652117 chr11:28483645 C/T cg06544937 chr11:28130018 METT5D1;KIF18A -0.48 -8.45 -0.32 2.02e-16 Bipolar disorder; BRCA cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg02475777 chr4:1388615 CRIPAK 0.37 7.94 0.3 9.15e-15 Longevity; BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg12000995 chr2:27665139 KRTCAP3 -0.33 -8.21 -0.31 1.26e-15 Total body bone mineral density; BRCA cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -8.94 -0.33 4.26e-18 Bipolar disorder; BRCA cis rs72781680 0.898 rs72798041 chr2:23953076 T/C cg08917208 chr2:24149416 ATAD2B 1.06 14.57 0.5 1.01e-41 Lymphocyte counts; BRCA cis rs7071206 0.947 rs4979902 chr10:79399946 C/T cg23888215 chr10:79422304 NA 0.6 11.27 0.41 5.41e-27 Bone mineral density; BRCA cis rs4727027 0.901 rs4727017 chr7:148822062 A/G cg23583168 chr7:148888333 NA -0.85 -19.52 -0.61 6.96e-67 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4660306 1.000 rs4660870 chr1:45995231 T/A cg24296786 chr1:45957014 TESK2 0.45 9.45 0.35 6.14e-20 Homocysteine levels; BRCA cis rs6912958 0.728 rs6923230 chr6:88213949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.52 -0.32 1.13e-16 Monocyte percentage of white cells; BRCA trans rs2562456 0.917 rs2681376 chr19:21715525 T/G cg25042112 chr7:64838748 ZNF92 0.47 8.6 0.32 6.31e-17 Pain; BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg04267008 chr7:1944627 MAD1L1 -0.59 -12.45 -0.44 5.26e-32 Bipolar disorder and schizophrenia; BRCA cis rs2559856 1.000 rs2559858 chr12:102089300 A/G cg12924262 chr12:102091054 CHPT1 0.38 8.74 0.33 2.11e-17 Blood protein levels; BRCA cis rs73242632 1.000 rs28474684 chr4:57875469 A/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.66 7.81 0.3 2.38e-14 Congenital heart disease (maternal effect); BRCA cis rs2777491 0.872 rs61037359 chr15:41585926 T/C cg18705301 chr15:41695430 NDUFAF1 -0.59 -13.55 -0.47 6.16e-37 Ulcerative colitis; BRCA cis rs7647973 0.626 rs35129566 chr3:49866584 T/G cg07636037 chr3:49044803 WDR6 -0.49 -8.28 -0.31 7.32e-16 Menarche (age at onset); BRCA cis rs910316 0.737 rs175077 chr14:75506875 G/A cg08847533 chr14:75593920 NEK9 -0.8 -18.81 -0.6 3.78e-63 Height; BRCA cis rs6598955 0.543 rs4585968 chr1:26535146 G/A cg12744634 chr1:26560303 CCDC21 0.32 8.64 0.32 4.46e-17 Obesity-related traits; BRCA cis rs4481887 0.830 rs4916126 chr1:248466604 G/A cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.79e-18 Common traits (Other); BRCA cis rs4727443 0.966 rs66748925 chr7:99589843 A/G cg22004693 chr7:99632812 ZKSCAN1 0.39 8.87 0.33 7.48e-18 Interstitial lung disease; BRCA cis rs514406 0.505 rs146750 chr1:53183447 C/G cg16325326 chr1:53192061 ZYG11B 0.91 25.0 0.7 9.57e-97 Monocyte count; BRCA trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg08975724 chr8:8085496 FLJ10661 -0.45 -8.97 -0.33 3.38e-18 Neuroticism; BRCA cis rs7617773 0.817 rs13072018 chr3:48320332 G/A cg11946769 chr3:48343235 NME6 0.67 13.79 0.48 4.88e-38 Coronary artery disease; BRCA cis rs1577917 1.000 rs2816821 chr6:86657084 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.45 -0.41 9.28e-28 Response to antipsychotic treatment; BRCA cis rs2243480 1.000 rs6949812 chr7:65387101 G/A cg18252515 chr7:66147081 NA -0.84 -12.14 -0.43 1.2e-30 Diabetic kidney disease; BRCA cis rs4268898 0.610 rs72791170 chr2:24449776 C/T cg06627628 chr2:24431161 ITSN2 -0.79 -15.02 -0.51 6.5e-44 Asthma; BRCA cis rs16854884 0.657 rs7637912 chr3:143749777 G/A cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA cis rs13031619 0.607 rs13011199 chr2:3694994 A/G cg19052272 chr2:3704530 ALLC 0.35 8.36 0.31 4.02e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs4363385 0.818 rs4845512 chr1:152995241 C/T cg25856811 chr1:152973957 SPRR3 -0.31 -8.2 -0.31 1.28e-15 Inflammatory skin disease; BRCA cis rs477692 1.000 rs558764 chr10:131426957 G/T cg05714579 chr10:131428358 MGMT -0.53 -12.35 -0.44 1.46e-31 Response to temozolomide; BRCA cis rs6580649 0.598 rs1793913 chr12:48387025 T/A cg05342945 chr12:48394962 COL2A1 -0.47 -9.43 -0.35 7.64e-20 Lung cancer; BRCA cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg12463550 chr7:65579703 CRCP 0.38 8.12 0.31 2.38e-15 Aortic root size; BRCA cis rs11792861 0.926 rs3750451 chr9:111822866 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.45 8.18 0.31 1.48e-15 Menarche (age at onset); BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.54 -0.32 9.45e-17 Total body bone mineral density; BRCA cis rs4664304 1.000 rs55977890 chr2:160776866 C/T cg01092293 chr2:160761427 LY75 -0.41 -9.62 -0.36 1.56e-20 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7903847 0.642 rs10882926 chr10:99160690 C/T cg20016023 chr10:99160130 RRP12 0.26 8.3 0.31 6.14e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs798554 0.591 rs1182156 chr7:2901084 G/T cg04166393 chr7:2884313 GNA12 0.48 10.28 0.38 4.84e-23 Height; BRCA cis rs9486719 0.948 rs11152952 chr6:96894303 A/G cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs793571 0.590 rs4775094 chr15:59115995 A/G cg05156742 chr15:59063176 FAM63B 0.5 10.17 0.37 1.25e-22 Schizophrenia; BRCA trans rs4689592 0.546 rs10937784 chr4:7060935 G/C cg07817883 chr1:32538562 TMEM39B -0.43 -8.5 -0.32 1.3e-16 Monocyte percentage of white cells; BRCA trans rs208520 0.742 rs208454 chr6:66907783 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -15.98 -0.53 1.37e-48 Exhaled nitric oxide output; BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.97 18.23 0.58 4.19e-60 Platelet count; BRCA trans rs57221529 0.713 rs12521091 chr5:590710 G/T cg25482853 chr8:67687455 SGK3 0.98 15.22 0.52 7.22e-45 Lung disease severity in cystic fibrosis; BRCA trans rs6582630 0.555 rs2004152 chr12:38478951 C/T cg06521331 chr12:34319734 NA -0.51 -9.31 -0.35 2.03e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs7208859 0.673 rs11080138 chr17:29224542 A/G cg13385521 chr17:29058706 SUZ12P 0.62 8.49 0.32 1.49e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg22907277 chr7:1156413 C7orf50 0.59 8.98 0.33 3.05e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.962 rs4699605 chr4:99064379 A/G cg03676636 chr4:99064102 C4orf37 0.23 8.19 0.31 1.47e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg21573476 chr21:45109991 RRP1B -0.35 -8.92 -0.33 4.7e-18 Mean corpuscular volume; BRCA cis rs17092148 0.652 rs7269526 chr20:33053293 G/C cg16810054 chr20:33298113 TP53INP2 0.44 9.46 0.35 5.74e-20 Neuroticism; BRCA cis rs1941023 0.606 rs3825020 chr11:60184191 G/A cg08716584 chr11:60157161 MS4A7 -0.36 -8.53 -0.32 1.08e-16 Congenital heart disease (maternal effect); BRCA cis rs55665837 1.000 rs11023215 chr11:14436970 C/T cg19336497 chr11:14380999 RRAS2 -0.36 -9.34 -0.35 1.6e-19 Vitamin D levels; BRCA trans rs3960554 0.529 rs6465049 chr7:75874489 A/G cg19862616 chr7:65841803 NCRNA00174 0.46 10.36 0.38 2.44e-23 Eotaxin levels; BRCA trans rs4332037 0.539 rs1533827 chr7:2074290 A/G cg11693508 chr17:37793320 STARD3 -0.55 -10.46 -0.38 9.66e-24 Bipolar disorder; BRCA cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg04455712 chr21:45112962 RRP1B 0.41 10.51 0.38 5.95e-24 Mean corpuscular volume; BRCA cis rs2153535 0.580 rs1577471 chr6:8485905 T/A cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.93e-24 Motion sickness; BRCA cis rs10751667 0.560 rs7924794 chr11:962745 A/T cg01483505 chr11:975446 AP2A2 0.32 8.72 0.33 2.44e-17 Alzheimer's disease (late onset); BRCA cis rs9443645 0.901 rs10455356 chr6:79664748 T/C cg18132916 chr6:79620363 NA -0.48 -11.03 -0.4 5.2e-26 Intelligence (multi-trait analysis); BRCA cis rs7267979 1.000 rs2257432 chr20:25271086 T/C cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1552244 1.000 rs7648104 chr3:10073311 C/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs7666738 0.791 rs2903142 chr4:99040071 C/T cg05340658 chr4:99064831 C4orf37 0.7 17.4 0.57 8.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs12618769 0.652 rs1516085 chr2:99232312 G/A cg10123293 chr2:99228465 UNC50 0.41 8.4 0.32 2.87e-16 Bipolar disorder; BRCA cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.67 -0.42 1.13e-28 Bipolar disorder; BRCA cis rs10751667 0.643 rs10794352 chr11:946294 T/C cg10932868 chr11:921992 NA 0.49 12.57 0.45 1.54e-32 Alzheimer's disease (late onset); BRCA cis rs1707322 1.000 rs11211248 chr1:46476844 A/G cg03146154 chr1:46216737 IPP 0.45 10.13 0.37 1.84e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6604026 0.740 rs6700585 chr1:93364156 T/G cg17283838 chr1:93427260 FAM69A -0.4 -8.16 -0.31 1.82e-15 Multiple sclerosis; BRCA cis rs2576037 0.526 rs2571026 chr18:44561795 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.6 12.61 0.45 1.02e-32 Personality dimensions; BRCA trans rs3857536 0.706 rs7755994 chr6:66891747 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.47 -9.49 -0.35 4.6e-20 Blood trace element (Cu levels); BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.56 -0.42 3.35e-28 Lymphocyte counts; BRCA cis rs910316 0.737 rs175084 chr14:75519175 C/T cg08847533 chr14:75593920 NEK9 -0.79 -18.58 -0.59 6.17e-62 Height; BRCA cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg17845761 chr1:175162550 KIAA0040 0.25 9.55 0.35 2.79e-20 Alcohol dependence; BRCA cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.11 0.31 2.6e-15 Uric acid levels; BRCA cis rs929354 0.935 rs1182392 chr7:157036200 C/T cg17757837 chr7:157058334 UBE3C -0.62 -14.74 -0.5 1.46e-42 Body mass index; BRCA cis rs1401999 0.659 rs7622660 chr3:183753337 C/T cg01324343 chr3:183735012 ABCC5 0.8 17.9 0.58 2.13e-58 Anterior chamber depth; BRCA cis rs10256972 0.552 rs2960830 chr7:1200641 T/C cg26608667 chr7:1196370 ZFAND2A 0.41 9.99 0.37 6.22e-22 Longevity;Endometriosis; BRCA cis rs6912958 0.559 rs499373 chr6:88042062 A/T cg08069147 chr6:88032118 GJB7;C6orf162 0.6 12.25 0.44 3.77e-31 Monocyte percentage of white cells; BRCA cis rs826838 1.000 rs34254519 chr12:39041235 G/A cg26384229 chr12:38710491 ALG10B 0.83 22.31 0.66 5.94e-82 Heart rate; BRCA trans rs1814175 0.527 rs7110797 chr11:49644096 T/C cg15704280 chr7:45808275 SEPT13 -0.73 -15.02 -0.51 7e-44 Height; BRCA cis rs6860806 0.507 rs183898 chr5:131716902 C/G cg07395648 chr5:131743802 NA 0.37 8.1 0.31 2.77e-15 Breast cancer; BRCA cis rs11677370 0.603 rs1454242 chr2:3848532 G/A cg17052675 chr2:3827356 NA -0.51 -12.58 -0.45 1.4e-32 Type 2 diabetes; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg23978390 chr7:1156363 C7orf50 0.48 11.2 0.41 9.98e-27 Longevity;Endometriosis; BRCA cis rs12368653 1.000 rs12368653 chr12:58133256 A/G cg18357645 chr12:58087776 OS9 -0.31 -8.3 -0.31 6.06e-16 Multiple sclerosis; BRCA trans rs2204008 0.744 rs11514073 chr12:38399553 A/C cg06521331 chr12:34319734 NA -0.51 -9.11 -0.34 1.04e-18 Bladder cancer; BRCA trans rs11039798 0.841 rs7294179 chr11:48765408 G/A cg15704280 chr7:45808275 SEPT13 0.65 7.82 0.3 2.18e-14 Axial length; BRCA cis rs6701037 0.625 rs34270511 chr1:175128543 C/T cg17845761 chr1:175162550 KIAA0040 -0.27 -10.05 -0.37 3.53e-22 Alcohol dependence; BRCA cis rs1008375 1.000 rs2872959 chr4:17677163 G/A cg04450456 chr4:17643702 FAM184B -0.34 -9.84 -0.36 2.23e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs3942852 0.774 rs2279823 chr11:48146092 T/C cg15704280 chr7:45808275 SEPT13 -0.49 -9.4 -0.35 9.44e-20 Acute lymphoblastic leukemia (childhood); BRCA cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 6.16e-35 Bone mineral density; BRCA cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg08999081 chr20:33150536 PIGU -0.47 -12.84 -0.45 9.74e-34 Glomerular filtration rate (creatinine); BRCA cis rs9393777 0.513 rs9379895 chr6:26592707 A/G cg12826209 chr6:26865740 GUSBL1 0.58 10.33 0.38 3.08e-23 Intelligence (multi-trait analysis); BRCA cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg24675658 chr1:53192096 ZYG11B 0.63 15.2 0.52 8.74e-45 Monocyte count; BRCA cis rs17685 0.753 rs10233282 chr7:75790081 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg17330251 chr7:94953956 PON1 -0.43 -9.08 -0.34 1.33e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1008375 0.966 rs10939758 chr4:17698255 C/T cg16339924 chr4:17578868 LAP3 0.57 13.86 0.48 2.17e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.683 rs16921819 chr8:58107936 G/T cg11062466 chr8:58055876 NA 0.41 7.84 0.3 1.84e-14 Developmental language disorder (linguistic errors); BRCA cis rs7020830 0.898 rs12554874 chr9:37073902 C/T cg14294708 chr9:37120828 ZCCHC7 1.17 40.29 0.85 1.44e-177 Schizophrenia; BRCA cis rs10782582 0.593 rs11163904 chr1:76121208 A/G cg03433033 chr1:76189801 ACADM 0.46 9.67 0.36 9.77e-21 Daytime sleep phenotypes; BRCA cis rs796364 0.951 rs281793 chr2:200847990 G/A cg23649088 chr2:200775458 C2orf69 0.56 8.22 0.31 1.1e-15 Schizophrenia; BRCA cis rs2019137 0.936 rs2241978 chr2:113954006 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 -0.53 -11.02 -0.4 5.67e-26 Lymphocyte counts; BRCA cis rs1018836 0.884 rs2073640 chr8:91594853 A/G cg16814680 chr8:91681699 NA -0.57 -12.49 -0.44 3.47e-32 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs13046373 0.535 rs13051529 chr21:32029743 G/C cg06468780 chr21:31798236 KRTAP13-3 0.34 8.31 0.31 5.76e-16 HDL cholesterol; BRCA trans rs7824557 0.736 rs35392635 chr8:11164349 G/C cg15556689 chr8:8085844 FLJ10661 0.37 8.73 0.33 2.21e-17 Retinal vascular caliber; BRCA cis rs826838 0.967 rs7970069 chr12:38810631 T/C cg26384229 chr12:38710491 ALG10B 0.84 22.26 0.66 1.06e-81 Heart rate; BRCA cis rs7593730 0.636 rs6757491 chr2:161147743 G/C cg22609984 chr2:161126801 NA 0.37 8.09 0.3 3.05e-15 Type 2 diabetes; BRCA cis rs2239547 0.522 rs7652131 chr3:52997154 C/T cg11645453 chr3:52864694 ITIH4 0.44 10.65 0.39 1.73e-24 Schizophrenia; BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.69 0.42 9.44e-29 Tonsillectomy; BRCA cis rs7666738 0.830 rs10031292 chr4:99056877 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.33 0.57 1.88e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs13046373 0.535 rs1395778 chr21:31985502 G/C cg24082983 chr21:31802169 KRTAP13-4 0.33 8.26 0.31 8.46e-16 HDL cholesterol; BRCA cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs796364 1.000 rs11680723 chr2:200810957 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.79 -11.37 -0.41 2.07e-27 Schizophrenia; BRCA cis rs2760061 0.569 rs621631 chr1:228114728 A/G cg02753203 chr1:228287806 NA -0.57 -11.98 -0.43 5.42e-30 Diastolic blood pressure; BRCA cis rs2559856 1.000 rs2559860 chr12:102087636 C/T cg12924262 chr12:102091054 CHPT1 0.37 8.5 0.32 1.32e-16 Blood protein levels; BRCA cis rs911186 0.786 rs72842197 chr6:27067083 C/T cg12292205 chr6:26970375 C6orf41 -0.64 -10.0 -0.37 5.8e-22 Autism spectrum disorder or schizophrenia; BRCA cis rs72781680 0.611 rs2303287 chr2:24302246 A/G cg08917208 chr2:24149416 ATAD2B -0.56 -8.62 -0.32 5.44e-17 Lymphocyte counts; BRCA cis rs832540 0.656 rs702689 chr5:56177443 G/A cg12311346 chr5:56204834 C5orf35 -0.45 -9.2 -0.34 5.03e-19 Coronary artery disease; BRCA cis rs1008375 1.000 rs6449319 chr4:17640283 T/A cg15017067 chr4:17643749 FAM184B 0.32 9.82 0.36 2.68e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.534 rs11052983 chr12:34045787 C/A cg26384229 chr12:38710491 ALG10B 0.57 12.23 0.44 4.52e-31 Morning vs. evening chronotype; BRCA cis rs11098499 0.863 rs6534141 chr4:120485223 A/T cg09307838 chr4:120376055 NA 0.69 14.89 0.51 2.79e-43 Corneal astigmatism; BRCA cis rs7246657 0.943 rs3803895 chr19:37898669 A/G cg18154014 chr19:37997991 ZNF793 0.47 9.37 0.35 1.25e-19 Coronary artery calcification; BRCA cis rs7264396 0.622 rs3787165 chr20:34228946 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.44 -0.52 6.09e-46 Total cholesterol levels; BRCA cis rs11229555 0.874 rs11605297 chr11:58296806 G/A cg15696309 chr11:58395628 NA -0.53 -11.54 -0.42 4.18e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs1997103 1.000 rs4947501 chr7:55407342 C/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg09165964 chr15:75287851 SCAMP5 0.83 18.89 0.6 1.44e-63 Blood trace element (Zn levels); BRCA cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.5 -9.86 -0.36 1.97e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13082711 0.911 rs13089870 chr3:27447626 C/T cg02860705 chr3:27208620 NA 0.54 10.73 0.39 8.04e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs853679 0.517 rs3173443 chr6:28137027 T/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs1862618 0.713 rs832550 chr5:56182589 C/T cg24531977 chr5:56204891 C5orf35 -0.86 -17.89 -0.58 2.57e-58 Initial pursuit acceleration; BRCA cis rs9875589 0.957 rs62234598 chr3:13964610 G/A cg19554555 chr3:13937349 NA 0.4 8.46 0.32 1.8e-16 Ovarian reserve; BRCA trans rs2197308 0.565 rs4123923 chr12:37857684 T/C cg06521331 chr12:34319734 NA -0.54 -9.75 -0.36 4.89e-21 Morning vs. evening chronotype; BRCA cis rs4363385 0.818 rs3820141 chr1:153004778 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -9.22 -0.34 4.37e-19 Inflammatory skin disease; BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.4e-19 Tonsillectomy; BRCA cis rs7264396 0.690 rs2425175 chr20:34445563 G/A cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.13 0.31 2.28e-15 Total cholesterol levels; BRCA cis rs801193 1.000 rs2659909 chr7:66160279 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.36 8.14 0.31 2.14e-15 Aortic root size; BRCA cis rs3820928 1.000 rs10197757 chr2:227763244 A/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.53 -0.32 1.04e-16 Pulmonary function; BRCA cis rs2072499 1.000 rs2540173 chr1:156188214 A/G cg25208724 chr1:156163844 SLC25A44 1.03 33.1 0.79 1.08e-140 Testicular germ cell tumor; BRCA cis rs10751667 0.666 rs7395267 chr11:962326 C/A ch.11.42038R chr11:967971 AP2A2 0.52 16.63 0.55 7.59e-52 Alzheimer's disease (late onset); BRCA cis rs6120849 0.754 rs6087667 chr20:33651887 A/G cg24642439 chr20:33292090 TP53INP2 0.6 10.28 0.38 4.66e-23 Protein C levels; BRCA cis rs6964587 0.900 rs11984136 chr7:91766953 T/C cg17063962 chr7:91808500 NA 0.61 14.57 0.5 9.53e-42 Breast cancer; BRCA cis rs738321 0.723 rs9622726 chr22:38506688 A/G cg25457927 chr22:38595422 NA -0.33 -11.38 -0.41 1.94e-27 Breast cancer; BRCA cis rs7772486 0.686 rs2179323 chr6:145982786 T/G cg23711669 chr6:146136114 FBXO30 -0.71 -16.98 -0.56 1.23e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs12368653 0.616 rs1027315 chr12:58034192 T/C cg18357645 chr12:58087776 OS9 0.35 9.51 0.35 3.7799999999999997e-20 Multiple sclerosis; BRCA cis rs8114671 0.836 rs6141526 chr20:33615255 G/T cg24642439 chr20:33292090 TP53INP2 -0.41 -8.19 -0.31 1.42e-15 Height; BRCA cis rs7618915 0.547 rs62255362 chr3:52699741 C/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.84 0.36 2.34e-21 Bipolar disorder; BRCA cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg03146154 chr1:46216737 IPP 0.52 11.63 0.42 1.68e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2840044 0.554 rs225267 chr17:33964228 T/C cg19694781 chr19:47549865 TMEM160 -1.06 -21.58 -0.65 5.04e-78 Response to radiotherapy in cancer (late toxicity); BRCA cis rs7927592 0.956 rs12365160 chr11:68250419 A/G cg20283391 chr11:68216788 NA -0.45 -8.88 -0.33 6.46e-18 Total body bone mineral density; BRCA cis rs9858542 0.903 rs11917431 chr3:49644012 C/T cg03060546 chr3:49711283 APEH -0.56 -10.88 -0.4 2.16e-25 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9394841 0.667 rs3747750 chr6:41760372 C/G cg08135965 chr6:41755394 TOMM6 0.5 8.13 0.31 2.18e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs17095355 1.000 rs1376111 chr10:111707255 C/T cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.92 -0.37 1.14e-21 Biliary atresia; BRCA cis rs2153535 0.580 rs2327056 chr6:8443305 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs2204008 0.569 rs11495449 chr12:37995753 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.06 0.37 3.41e-22 Bladder cancer; BRCA cis rs3096299 0.685 rs4785675 chr16:89539974 T/C cg08392591 chr16:89556376 ANKRD11 0.55 13.45 0.47 1.7e-36 Multiple myeloma (IgH translocation); BRCA cis rs13161895 1.000 rs35135297 chr5:179469532 T/C cg02702477 chr5:179499311 RNF130 0.46 8.53 0.32 1.03e-16 LDL cholesterol; BRCA cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg06212747 chr3:49208901 KLHDC8B 0.47 9.4 0.35 9.73e-20 Parkinson's disease; BRCA cis rs8062405 0.755 rs4788076 chr16:28570005 C/T cg16576597 chr16:28551801 NUPR1 0.35 9.64 0.36 1.28e-20 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9393692 0.905 rs9357004 chr6:26303319 A/G cg05868516 chr6:26286170 HIST1H4H 0.43 9.61 0.36 1.6e-20 Educational attainment; BRCA cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg19274703 chr22:41806451 NA 0.39 9.44 0.35 6.82e-20 Vitiligo; BRCA cis rs10208940 0.920 rs10205573 chr2:68829419 A/T cg12452813 chr2:68675892 NA 0.5 8.73 0.33 2.14e-17 Urate levels in lean individuals; BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -9.04 -0.34 1.88e-18 Tonsillectomy; BRCA cis rs12586317 0.547 rs77262907 chr14:35495734 C/G cg05294307 chr14:35346193 BAZ1A -0.59 -10.22 -0.37 8.46e-23 Psoriasis; BRCA cis rs736801 0.754 rs2706336 chr5:131799961 T/C cg14196790 chr5:131705035 SLC22A5 -0.41 -10.1 -0.37 2.35e-22 Breast cancer;Mosquito bite size; BRCA cis rs4363385 0.747 rs1577963 chr1:152961882 T/C cg21543102 chr1:152974771 SPRR3 -0.28 -8.15 -0.31 1.88e-15 Inflammatory skin disease; BRCA cis rs7666738 0.753 rs11097594 chr4:98944486 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.27e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 0.727 rs6678348 chr1:76332463 C/T cg10523679 chr1:76189770 ACADM 0.68 12.51 0.44 2.85e-32 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs736408 0.812 rs2240920 chr3:52831009 A/G cg11041457 chr3:52719354 GNL3;PBRM1 -0.31 -9.5 -0.35 4.18e-20 Bipolar disorder; BRCA cis rs10899021 1.000 rs11236186 chr11:74362865 G/A cg25880958 chr11:74394337 NA -0.5 -7.89 -0.3 1.29e-14 Response to metformin (IC50); BRCA cis rs6598955 0.671 rs10902732 chr1:26606174 A/C cg04990556 chr1:26633338 UBXN11 0.54 8.86 0.33 8.17e-18 Obesity-related traits; BRCA cis rs736408 0.677 rs1042779 chr3:52821011 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.54 0.42 4.17e-28 Bipolar disorder; BRCA cis rs36051895 0.664 rs10974963 chr9:5101305 G/A cg02405213 chr9:5042618 JAK2 -0.49 -8.81 -0.33 1.15e-17 Pediatric autoimmune diseases; BRCA cis rs875971 0.545 rs4718348 chr7:65906576 A/G cg11764359 chr7:65958608 NA 0.64 11.31 0.41 3.77e-27 Aortic root size; BRCA cis rs7727544 0.684 rs274560 chr5:131719450 T/C cg24060327 chr5:131705240 SLC22A5 0.47 9.64 0.36 1.29e-20 Blood metabolite levels; BRCA cis rs12216125 0.554 rs6942196 chr6:26072804 A/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.55 0.42 3.81e-28 Iron status biomarkers; BRCA cis rs10752881 1.000 rs6697739 chr1:182983333 A/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.41e-52 Colorectal cancer; BRCA cis rs9811920 0.599 rs61148087 chr3:99539891 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.66 -15.04 -0.51 5.76e-44 Axial length; BRCA cis rs9649213 0.574 rs3801257 chr7:97991792 A/G cg01877450 chr7:97915802 BRI3 -0.39 -8.86 -0.33 7.95e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs6087990 0.806 rs6141814 chr20:31368960 C/A cg13636640 chr20:31349939 DNMT3B 0.62 19.09 0.6 1.19e-64 Ulcerative colitis; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg24101359 chr6:42928495 GNMT 0.55 12.55 0.44 1.87e-32 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs875971 0.540 rs736270 chr7:65428822 T/C cg18876405 chr7:65276391 NA 0.69 17.99 0.58 7.89e-59 Aortic root size; BRCA cis rs875971 0.862 rs7783779 chr7:65796626 A/G cg11764359 chr7:65958608 NA -0.76 -16.96 -0.56 1.47e-53 Aortic root size; BRCA cis rs1580019 0.961 rs766660 chr7:32499077 A/G cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.27 0.54 4.93e-50 Cognitive ability; BRCA cis rs4742903 1.000 rs3780535 chr9:106894211 A/C cg21169611 chr9:106856078 SMC2 0.37 9.69 0.36 8.6e-21 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs7267979 1.000 rs2258563 chr20:25273435 C/T cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.46e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2204008 0.777 rs6582664 chr12:37947022 A/G cg13010199 chr12:38710504 ALG10B -0.4 -8.56 -0.32 8.56e-17 Bladder cancer; BRCA cis rs9287719 0.674 rs12622551 chr2:10720443 G/A cg00105475 chr2:10696890 NA 0.41 9.19 0.34 5.52e-19 Prostate cancer; BRCA cis rs7851660 0.967 rs12348691 chr9:100608682 G/A cg13688889 chr9:100608707 NA -0.35 -8.63 -0.32 5.03e-17 Strep throat; BRCA cis rs2836974 1.000 rs28360661 chr21:40681972 G/C cg11890956 chr21:40555474 PSMG1 0.98 22.85 0.67 6.67e-85 Cognitive function; BRCA cis rs7249142 0.506 rs8101388 chr19:19293938 A/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.45 -10.74 -0.39 7.49e-25 IgG glycosylation; BRCA trans rs3942852 0.774 rs10838814 chr11:48187178 G/A cg15704280 chr7:45808275 SEPT13 -0.53 -10.26 -0.38 5.58e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg22974920 chr21:40686053 BRWD1 0.39 8.95 0.33 3.88e-18 Cognitive function; BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg00080972 chr5:178986291 RUFY1 0.44 10.98 0.4 7.99e-26 Lung cancer; BRCA cis rs7727544 0.716 rs7720230 chr5:131592405 T/G cg12564285 chr5:131593104 PDLIM4 0.33 8.28 0.31 7.07e-16 Blood metabolite levels; BRCA cis rs10504229 0.683 rs17194487 chr8:58104912 C/T cg24829409 chr8:58192753 C8orf71 -0.5 -8.21 -0.31 1.24e-15 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.825 rs10056879 chr5:93282218 C/A cg25358565 chr5:93447407 FAM172A 1.23 18.11 0.58 1.82e-59 Diabetic retinopathy; BRCA trans rs629535 0.783 rs510632 chr8:70034570 A/G cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.5 -0.35 4.13e-20 Tonsillectomy; BRCA cis rs7267979 0.966 rs2387882 chr20:25378802 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.79 -0.33 1.43e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1059312 0.966 rs12370194 chr12:129277250 A/T cg23521905 chr12:129298690 SLC15A4;MGC16384 0.27 8.86 0.33 7.79e-18 Systemic lupus erythematosus; BRCA cis rs941873 0.835 rs10762859 chr10:81103370 T/A cg08514558 chr10:81106712 PPIF 0.37 8.91 0.33 5.23e-18 Height; BRCA cis rs10189230 0.868 rs5002064 chr2:222353508 G/A cg14652038 chr2:222343519 EPHA4 0.47 13.02 0.46 1.53e-34 Urate levels in lean individuals; BRCA cis rs34172651 0.517 rs34172679 chr16:24840381 C/T cg06028605 chr16:24865363 SLC5A11 0.4 8.34 0.31 4.6e-16 Intelligence (multi-trait analysis); BRCA cis rs9287719 0.901 rs10210859 chr2:10733929 C/T cg00105475 chr2:10696890 NA 0.44 10.28 0.38 4.62e-23 Prostate cancer; BRCA cis rs10504229 0.728 rs78765835 chr8:58154337 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs3008870 0.755 rs1925410 chr1:67365230 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.63 -13.61 -0.47 3.22e-37 Lymphocyte percentage of white cells; BRCA cis rs6545883 0.759 rs777585 chr2:61412559 A/G cg15711740 chr2:61764176 XPO1 0.48 11.86 0.42 1.82e-29 Tuberculosis; BRCA cis rs7523050 0.908 rs12405585 chr1:109397229 C/A cg08274380 chr1:109419600 GPSM2 0.84 12.88 0.45 6.8e-34 Fat distribution (HIV); BRCA cis rs7020830 0.867 rs1339553 chr9:37266123 C/G cg14294708 chr9:37120828 ZCCHC7 1.13 37.13 0.83 1.11e-161 Schizophrenia; BRCA cis rs2742234 0.541 rs871763 chr10:43734188 C/T cg15436174 chr10:43711423 RASGEF1A 0.52 10.43 0.38 1.25e-23 Hirschsprung disease; BRCA cis rs2836974 0.602 rs2037925 chr21:40699931 C/T cg06238570 chr21:40685208 BRWD1 -0.43 -8.53 -0.32 1.04e-16 Cognitive function; BRCA cis rs710216 0.536 rs710222 chr1:43413653 A/G cg03128534 chr1:43423976 SLC2A1 0.51 12.28 0.44 2.84e-31 Red cell distribution width; BRCA cis rs7246657 0.722 rs16958863 chr19:38124235 A/G cg18154014 chr19:37997991 ZNF793 0.47 8.98 0.33 2.9e-18 Coronary artery calcification; BRCA cis rs881375 0.631 rs10739577 chr9:123668854 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.45 9.29 0.34 2.48e-19 Rheumatoid arthritis; BRCA cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg08885076 chr2:99613938 TSGA10 0.46 10.91 0.4 1.53e-25 Chronic sinus infection; BRCA cis rs780096 0.565 rs780104 chr2:27677691 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg05623727 chr3:50126028 RBM5 0.37 8.69 0.33 2.96e-17 Intelligence (multi-trait analysis); BRCA cis rs6952809 0.532 rs6461361 chr7:2432167 A/G cg05083358 chr7:2394359 EIF3B -0.52 -8.12 -0.31 2.44e-15 Multiple sclerosis; BRCA cis rs6582630 0.634 rs10748443 chr12:38734062 G/T cg26384229 chr12:38710491 ALG10B 0.47 12.21 0.43 5.95e-31 Drug-induced liver injury (flucloxacillin); BRCA trans rs1005277 0.540 rs289638 chr10:37923731 G/A cg17830980 chr10:43048298 ZNF37B -0.41 -9.17 -0.34 6.43e-19 Extrinsic epigenetic age acceleration; BRCA trans rs6499188 0.522 rs8046299 chr16:68672346 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 0.48 8.7 0.33 2.82e-17 Ulcerative colitis; BRCA cis rs6952808 1.000 rs4721122 chr7:1893311 C/G cg02951883 chr7:2050386 MAD1L1 -0.4 -8.83 -0.33 9.67e-18 Bipolar disorder and schizophrenia; BRCA cis rs9790314 0.718 rs6774635 chr3:160847908 A/G cg03342759 chr3:160939853 NMD3 -0.54 -10.5 -0.38 6.55e-24 Morning vs. evening chronotype; BRCA cis rs611744 0.604 rs6469170 chr8:109305277 T/C cg21045802 chr8:109455806 TTC35 0.39 8.97 0.33 3.35e-18 Dupuytren's disease; BRCA cis rs77972916 0.536 rs11694173 chr2:43590899 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.66 10.28 0.38 4.61e-23 Granulocyte percentage of myeloid white cells; BRCA cis rs10911251 0.546 rs2147578 chr1:183107699 G/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.46 0.55 5.2e-51 Colorectal cancer; BRCA cis rs7666738 0.830 rs11729753 chr4:98803267 T/A cg17366294 chr4:99064904 C4orf37 0.41 9.27 0.34 2.92e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.690 rs4679930 chr3:160842875 C/G cg03342759 chr3:160939853 NMD3 -0.53 -11.33 -0.41 3.02e-27 Morning vs. evening chronotype; BRCA cis rs765787 0.530 rs2899381 chr15:45529630 C/T cg24006582 chr15:45444508 DUOX1 -0.53 -11.02 -0.4 5.54e-26 Uric acid levels; BRCA cis rs1949733 0.701 rs2631754 chr4:8449233 A/G cg13073564 chr4:8508604 NA -0.39 -10.56 -0.39 3.78e-24 Response to antineoplastic agents; BRCA trans rs8002861 0.641 rs4942252 chr13:44443039 C/T cg12856521 chr11:46389249 DGKZ 0.37 8.02 0.3 5.16e-15 Leprosy; BRCA trans rs7819412 0.521 rs9329238 chr8:11033737 C/T cg06636001 chr8:8085503 FLJ10661 -0.4 -8.05 -0.3 4.18e-15 Triglycerides; BRCA cis rs2842992 0.830 rs2842966 chr6:160141592 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.54 11.39 0.41 1.65e-27 Age-related macular degeneration (geographic atrophy); BRCA cis rs875971 0.862 rs10950033 chr7:65739673 A/G cg11764359 chr7:65958608 NA -0.77 -17.87 -0.58 3.29e-58 Aortic root size; BRCA cis rs9467711 0.591 rs13214280 chr6:26008620 C/T cg08501292 chr6:25962987 TRIM38 0.59 8.07 0.3 3.59e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs752010 0.841 rs6661784 chr1:42080312 A/T cg06885757 chr1:42089581 HIVEP3 0.24 9.15 0.34 7.69e-19 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs9503598 0.644 rs10498663 chr6:3430439 C/T cg09127107 chr6:3438702 SLC22A23 0.28 7.99 0.3 6.29e-15 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg00802000 chr16:706648 WDR90 -0.39 -9.37 -0.35 1.24e-19 Height; BRCA cis rs7582180 0.663 rs6542944 chr2:100988038 T/C cg14675211 chr2:100938903 LONRF2 0.44 9.66 0.36 1.08e-20 Intelligence (multi-trait analysis); BRCA trans rs6951245 1.000 rs78158942 chr7:1090440 G/T cg13565492 chr6:43139072 SRF -0.78 -10.66 -0.39 1.5e-24 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg00750074 chr16:89608354 SPG7 0.37 10.07 0.37 3.16e-22 Multiple myeloma (IgH translocation); BRCA cis rs10504229 0.683 rs11786845 chr8:58133642 T/C cg08219700 chr8:58056026 NA 0.47 8.51 0.32 1.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs9309711 0.736 rs28619526 chr2:3496804 T/C cg16153549 chr2:3496821 NA -0.45 -10.82 -0.39 3.6e-25 Neurofibrillary tangles; BRCA cis rs7666738 0.830 rs13149779 chr4:99010145 G/T cg03676636 chr4:99064102 C4orf37 0.21 8.11 0.31 2.58e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs68170813 0.599 rs11769901 chr7:106958505 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.72 -0.33 2.46e-17 Coronary artery disease; BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg24768116 chr2:27665128 KRTCAP3 -0.31 -7.88 -0.3 1.46e-14 Total body bone mineral density; BRCA cis rs7100689 0.646 rs10749581 chr10:82141651 A/G cg00277334 chr10:82204260 NA 0.41 8.13 0.31 2.27e-15 Post bronchodilator FEV1; BRCA cis rs801193 0.935 rs3800820 chr7:66147178 C/T cg18876405 chr7:65276391 NA -0.63 -15.5 -0.52 3.07e-46 Aortic root size; BRCA cis rs1878931 0.582 rs9937267 chr16:3421073 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 0.5 8.77 0.33 1.61e-17 Body mass index (adult); BRCA cis rs4665809 1.000 rs4233710 chr2:26291565 G/A cg08470875 chr2:26401718 FAM59B -0.62 -9.44 -0.35 6.78e-20 Gut microbiome composition (summer); BRCA cis rs9287719 0.967 rs728281 chr2:10750355 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA cis rs2032447 0.714 rs199739 chr6:25960509 A/C cg03264133 chr6:25882463 NA -0.6 -12.42 -0.44 7.38e-32 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.687 rs6915558 chr6:79769056 A/T cg18132916 chr6:79620363 NA -0.49 -11.13 -0.4 2.05e-26 Intelligence (multi-trait analysis); BRCA cis rs735860 0.726 rs209507 chr6:53194768 T/A cg10236188 chr6:53219634 NA 0.38 8.05 0.3 4.13e-15 Glaucoma; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.37 -8.63 -0.32 4.96e-17 Longevity;Endometriosis; BRCA cis rs7584330 0.868 rs6760842 chr2:238398165 C/T cg08992911 chr2:238395768 MLPH -0.36 -7.85 -0.3 1.78e-14 Prostate cancer; BRCA cis rs7737355 0.947 rs1468303 chr5:130804400 T/C cg06307176 chr5:131281290 NA -0.53 -10.47 -0.38 8.48e-24 Life satisfaction; BRCA cis rs4975616 0.804 rs456366 chr5:1337070 T/C cg06550200 chr5:1325588 CLPTM1L -0.63 -13.2 -0.46 2.3e-35 Lung cancer; BRCA cis rs919433 0.963 rs1896854 chr2:198147776 G/T cg10820045 chr2:198174542 NA -0.4 -9.38 -0.35 1.09e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs11098499 0.562 rs58583086 chr4:120556362 A/G cg09307838 chr4:120376055 NA -0.58 -12.34 -0.44 1.57e-31 Corneal astigmatism; BRCA cis rs12618769 0.597 rs2278214 chr2:99135738 A/G cg10123293 chr2:99228465 UNC50 -0.41 -7.97 -0.3 7.52e-15 Bipolar disorder; BRCA cis rs7633770 0.786 rs1607737 chr3:46681846 G/C cg11219411 chr3:46661640 NA 0.65 16.96 0.56 1.59e-53 Coronary artery disease; BRCA cis rs12762955 0.561 rs7076107 chr10:1043647 T/C cg20503657 chr10:835505 NA -0.54 -9.75 -0.36 4.95e-21 Response to angiotensin II receptor blocker therapy; BRCA cis rs74417235 0.639 rs7443642 chr5:154053450 A/G cg08754654 chr5:154026448 NA -0.42 -10.07 -0.37 2.95e-22 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg11247378 chr22:39784982 NA -0.63 -15.43 -0.52 6.89e-46 Intelligence (multi-trait analysis); BRCA cis rs7903847 0.620 rs9787454 chr10:99155561 A/T cg20016023 chr10:99160130 RRP12 -0.26 -8.53 -0.32 1.03e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs74417235 0.684 rs7723312 chr5:154053249 A/G cg08754654 chr5:154026448 NA -0.41 -9.9 -0.36 1.32e-21 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs13191362 1.000 rs34443622 chr6:163208214 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.97 13.78 0.48 5.34e-38 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9837602 0.938 rs17393059 chr3:99761908 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.54 0.38 4.86e-24 Breast cancer; BRCA cis rs274567 0.501 rs272855 chr5:131687175 C/T cg07395648 chr5:131743802 NA -0.4 -8.5 -0.32 1.29e-16 Blood metabolite levels; BRCA cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg06064525 chr11:970664 AP2A2 -0.48 -16.28 -0.54 4.02e-50 Alzheimer's disease (late onset); BRCA trans rs9329221 0.617 rs483916 chr8:9793601 A/C cg06636001 chr8:8085503 FLJ10661 -0.57 -12.67 -0.45 5.36e-33 Neuroticism; BRCA cis rs67981189 0.896 rs2010061 chr14:71366196 A/G cg15816911 chr14:71606274 NA -0.36 -8.2 -0.31 1.32e-15 Schizophrenia; BRCA cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg04586622 chr2:25135609 ADCY3 0.4 9.29 0.34 2.44e-19 Body mass index; BRCA cis rs1707322 1.000 rs4660896 chr1:46372416 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg11766577 chr21:47581405 C21orf56 -0.49 -10.59 -0.39 2.87e-24 Testicular germ cell tumor; BRCA cis rs9287719 0.967 rs10206225 chr2:10758657 A/G cg02196655 chr2:10830764 NOL10 -0.31 -8.37 -0.31 3.73e-16 Prostate cancer; BRCA cis rs6450176 0.625 rs3822499 chr5:53289459 C/G ch.5.1024479R chr5:53302184 ARL15 -0.68 -15.15 -0.51 1.55e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA trans rs11039798 0.588 rs12294395 chr11:48476860 C/T cg15704280 chr7:45808275 SEPT13 0.54 9.1 0.34 1.11e-18 Axial length; BRCA cis rs412050 0.501 rs2876980 chr22:22106535 C/T cg17089214 chr22:22089827 YPEL1 -0.59 -9.29 -0.34 2.46e-19 Attention deficit hyperactivity disorder; BRCA cis rs4665809 0.590 rs6749046 chr2:26429451 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 5.01e-23 Gut microbiome composition (summer); BRCA trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg03929089 chr4:120376271 NA 0.76 17.67 0.57 3.58e-57 Coronary artery disease; BRCA cis rs11105298 0.891 rs1008764 chr12:89887649 T/C cg00757033 chr12:89920650 WDR51B 0.52 10.44 0.38 1.13e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs11105298 0.891 rs10858902 chr12:89927789 A/G cg00757033 chr12:89920650 WDR51B 0.54 11.01 0.4 6.42e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs1949733 0.598 rs4696838 chr4:8540349 A/G cg11789530 chr4:8429930 ACOX3 -0.52 -12.27 -0.44 3.27e-31 Response to antineoplastic agents; BRCA cis rs1215050 0.791 rs1215054 chr4:98863009 T/G cg05340658 chr4:99064831 C4orf37 -0.45 -10.24 -0.38 6.58e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7589728 1.000 rs11893832 chr2:88507537 G/C cg04511125 chr2:88470314 THNSL2 0.72 9.97 0.37 7.35e-22 Plasma clusterin levels; BRCA cis rs2882667 0.690 rs288031 chr5:138216066 T/C cg04439458 chr5:138467593 SIL1 -0.31 -7.96 -0.3 7.69e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs614226 1.000 rs591992 chr12:121019323 T/C cg01236616 chr12:121019343 POP5 1.24 27.02 0.73 8.09e-108 Type 1 diabetes nephropathy; BRCA cis rs35306767 0.855 rs56222464 chr10:867535 C/G cg26597838 chr10:835615 NA 1.3 21.81 0.65 2.87e-79 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg24692254 chr21:30365293 RNF160 0.62 14.15 0.49 9.85e-40 Selective IgA deficiency; BRCA cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.46 10.65 0.39 1.76e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs9469578 1.000 rs60447213 chr6:33715159 G/T cg18708504 chr6:33715942 IP6K3 0.7 10.19 0.37 1.09e-22 Phosphorus levels; BRCA cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg22903657 chr4:1355424 KIAA1530 -0.37 -8.08 -0.3 3.34e-15 Obesity-related traits; BRCA cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg23788917 chr6:8435910 SLC35B3 0.49 10.67 0.39 1.36e-24 Motion sickness; BRCA cis rs6582630 0.555 rs7305352 chr12:38473800 T/C cg26384229 chr12:38710491 ALG10B 0.77 17.64 0.57 4.77e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs6580649 0.941 rs1793933 chr12:48396450 G/T cg24011408 chr12:48396354 COL2A1 0.55 9.26 0.34 3.07e-19 Lung cancer; BRCA trans rs629535 0.748 rs58675625 chr8:70034924 T/C cg21567404 chr3:27674614 NA 1.0 21.1 0.64 2.04e-75 Dupuytren's disease; BRCA cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg08999081 chr20:33150536 PIGU 0.37 9.54 0.35 2.89e-20 Coronary artery disease; BRCA cis rs250677 0.687 rs10040624 chr5:148437579 A/G cg23229984 chr5:148520753 ABLIM3 0.35 8.83 0.33 1.03e-17 Breast cancer; BRCA cis rs4077515 0.901 rs11791262 chr9:139271919 C/T cg14019695 chr9:139328340 INPP5E 0.32 8.13 0.31 2.28e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg12436631 chr1:155007014 DCST1;DCST2 0.28 8.51 0.32 1.26e-16 Prostate cancer; BRCA cis rs514406 0.505 rs416968 chr1:53183513 A/G cg08859206 chr1:53392774 SCP2 -0.4 -8.3 -0.31 6.42e-16 Monocyte count; BRCA cis rs3806843 0.771 rs2563334 chr5:140107065 C/G cg26395211 chr5:140044315 WDR55 0.38 8.55 0.32 9.05e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg04944784 chr2:26401820 FAM59B -0.69 -11.47 -0.41 8.14e-28 Gut microbiome composition (summer); BRCA cis rs4481887 1.000 rs4244172 chr1:248466838 A/G cg00666640 chr1:248458726 OR2T12 0.3 8.3 0.31 6.21e-16 Common traits (Other); BRCA cis rs4237845 0.742 rs3751330 chr12:58290226 T/C cg02175503 chr12:58329896 NA 0.57 13.72 0.48 9.48e-38 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.875 rs11250121 chr8:11060311 A/C cg06636001 chr8:8085503 FLJ10661 -0.49 -9.91 -0.36 1.21e-21 Triglycerides; BRCA cis rs9790314 0.747 rs9820825 chr3:160848155 A/G cg03342759 chr3:160939853 NMD3 -0.5 -10.14 -0.37 1.7e-22 Morning vs. evening chronotype; BRCA cis rs6951245 0.938 rs117729148 chr7:1108531 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.71 -0.53 2.9e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7072216 0.763 rs12763044 chr10:100167451 C/G cg26618903 chr10:100175079 PYROXD2 -0.31 -8.96 -0.33 3.58e-18 Metabolite levels; BRCA cis rs812925 0.502 rs2084318 chr2:61652601 C/T cg15711740 chr2:61764176 XPO1 0.34 8.3 0.31 6.14e-16 Immature fraction of reticulocytes; BRCA trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg15556689 chr8:8085844 FLJ10661 -0.34 -9.29 -0.34 2.42e-19 Monocyte count; BRCA cis rs34779708 0.733 rs7087099 chr10:35541982 C/T cg03585969 chr10:35415529 CREM 0.45 9.14 0.34 7.92e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12050794 0.636 rs4506844 chr15:72509138 C/T cg16672083 chr15:72433130 SENP8 0.63 14.87 0.51 3.5e-43 Metabolite levels (HVA/MHPG ratio); BRCA cis rs9921222 0.521 rs78867928 chr16:368986 C/T cg12437481 chr16:420112 MRPL28 -0.4 -8.74 -0.33 1.99e-17 Bone mineral density (spine);Bone mineral density; BRCA cis rs4332037 0.707 rs56070303 chr7:1891015 C/T cg12432903 chr7:1882776 MAD1L1 0.45 8.03 0.3 4.66e-15 Bipolar disorder; BRCA cis rs3767633 0.925 rs2055539 chr1:161807866 T/C cg09175582 chr1:161736000 ATF6 0.53 8.81 0.33 1.18e-17 IgG glycosylation; BRCA cis rs10751667 0.666 rs10902242 chr11:949700 G/A cg10932868 chr11:921992 NA 0.49 12.63 0.45 8.39e-33 Alzheimer's disease (late onset); BRCA cis rs10992471 0.528 rs10429459 chr9:95258119 C/T cg14631576 chr9:95140430 CENPP 0.34 8.61 0.32 5.49e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7772486 0.754 rs9497401 chr6:146051271 T/C cg23711669 chr6:146136114 FBXO30 -0.78 -18.84 -0.6 2.64e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs875971 0.545 rs73142265 chr7:65699497 G/A cg11764359 chr7:65958608 NA 0.63 10.87 0.39 2.38e-25 Aortic root size; BRCA cis rs11711311 0.955 rs12636536 chr3:113474226 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.58 0.39 3.28e-24 IgG glycosylation; BRCA cis rs2652834 0.904 rs34786874 chr15:63397504 A/G cg05507819 chr15:63340323 TPM1 0.45 8.09 0.3 3.04e-15 HDL cholesterol; BRCA cis rs589448 0.967 rs2617834 chr12:69753365 T/C cg14784868 chr12:69753453 YEATS4 0.79 25.23 0.71 5.18e-98 Cerebrospinal fluid biomarker levels; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg09177884 chr7:1199841 ZFAND2A -0.43 -9.58 -0.35 2.12e-20 Longevity;Endometriosis; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg26516362 chr5:178986906 RUFY1 0.38 10.61 0.39 2.43e-24 Lung cancer; BRCA cis rs1008375 0.806 rs13139898 chr4:17706928 T/G cg16339924 chr4:17578868 LAP3 -0.54 -12.49 -0.44 3.58e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs495337 0.721 rs11696404 chr20:48548280 A/C cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg09877947 chr5:131593287 PDLIM4 -0.36 -7.91 -0.3 1.11e-14 Breast cancer; BRCA cis rs6570726 0.764 rs9403731 chr6:145907937 G/A cg13319975 chr6:146136371 FBXO30 -0.35 -8.15 -0.31 1.97e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9486715 0.867 rs12207471 chr6:96963782 A/G cg06623918 chr6:96969491 KIAA0776 0.9 25.8 0.71 3.81e-101 Headache; BRCA trans rs35110281 0.627 rs7282704 chr21:44966253 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.08 0.37 2.75e-22 Mean corpuscular volume; BRCA cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg11764359 chr7:65958608 NA 0.62 13.52 0.47 7.83e-37 Aortic root size; BRCA cis rs11190604 0.945 rs11190573 chr10:102233172 T/C cg07080220 chr10:102295463 HIF1AN 0.48 11.1 0.4 2.65e-26 Palmitoleic acid (16:1n-7) levels; BRCA trans rs35110281 0.720 rs162400 chr21:44950305 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.29 0.38 4.46e-23 Mean corpuscular volume; BRCA cis rs11229555 0.645 rs12802819 chr11:58174747 T/G cg15696309 chr11:58395628 NA -0.45 -9.74 -0.36 5.23e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs13118159 0.509 rs4974554 chr4:1356967 A/C cg05025164 chr4:1340916 KIAA1530 0.78 15.89 0.53 3.59e-48 Longevity; BRCA cis rs60871478 0.898 rs4720929 chr7:808009 T/C cg04727924 chr7:799746 HEATR2 -0.55 -10.78 -0.39 5.21e-25 Cerebrospinal P-tau181p levels; BRCA trans rs526821 0.595 rs532278 chr11:55344983 A/G cg11707556 chr5:10655725 ANKRD33B -0.37 -8.2 -0.31 1.36e-15 Pediatric bone mineral density (spine); BRCA cis rs9420 0.961 rs80304923 chr11:57522823 C/G cg19752551 chr11:57585705 CTNND1 -0.51 -12.56 -0.45 1.68e-32 Schizophrenia; BRCA cis rs10751667 1.000 rs10794349 chr11:945678 T/C cg10932868 chr11:921992 NA 0.39 9.46 0.35 5.65e-20 Alzheimer's disease (late onset); BRCA cis rs2075371 0.527 rs1862046 chr7:134023524 T/C cg02659138 chr7:134003124 SLC35B4 0.35 9.98 0.37 6.88e-22 Mean platelet volume; BRCA trans rs637571 0.780 rs677029 chr11:65683531 A/G cg17712092 chr4:129076599 LARP1B 0.82 21.88 0.65 1.22e-79 Eosinophil percentage of white cells; BRCA cis rs12142240 0.698 rs77185326 chr1:46818417 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.51 0.41 5.21e-28 Electroencephalogram traits; BRCA cis rs7539409 0.651 rs6696140 chr1:84317468 C/T cg10977910 chr1:84465055 TTLL7 -0.69 -10.92 -0.4 1.48e-25 Alzheimer's disease; BRCA cis rs9467773 1.000 rs6926629 chr6:26499903 T/C cg11502198 chr6:26597334 ABT1 0.47 9.48 0.35 4.85e-20 Intelligence (multi-trait analysis); BRCA cis rs4891159 0.790 rs11150953 chr18:74145491 G/A cg24786174 chr18:74118243 ZNF516 -0.77 -18.19 -0.58 6.88e-60 Longevity; BRCA cis rs798554 0.759 rs1636255 chr7:2892804 A/C cg14863265 chr7:2801509 GNA12 0.46 10.39 0.38 1.86e-23 Height; BRCA cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs10504073 0.584 rs10957337 chr8:49959027 G/T cg00325661 chr8:49890786 NA 0.48 13.72 0.48 9.95e-38 Blood metabolite ratios; BRCA cis rs2882667 0.931 rs10068237 chr5:138337960 T/A cg04439458 chr5:138467593 SIL1 -0.34 -9.16 -0.34 6.81e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg24450063 chr1:156163899 SLC25A44 1.11 35.2 0.81 9.83e-152 Testicular germ cell tumor; BRCA cis rs7586879 0.796 rs11684619 chr2:25078859 G/A cg04586622 chr2:25135609 ADCY3 0.37 8.98 0.33 2.95e-18 Body mass index; BRCA cis rs17253792 0.915 rs79100824 chr14:56179606 C/T cg01858014 chr14:56050164 KTN1 -0.67 -8.24 -0.31 9.82e-16 Putamen volume; BRCA cis rs736408 0.608 rs2239547 chr3:52855229 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -10.34 -0.38 2.93e-23 Bipolar disorder; BRCA cis rs798554 0.610 rs1182173 chr7:2878016 C/G cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 9.02e-16 Height; BRCA trans rs9858542 0.953 rs4625 chr3:49572140 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.38 -9.48 -0.35 4.72e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6952808 0.501 rs3778999 chr7:2180885 G/A cg03354898 chr7:1950403 MAD1L1 -0.44 -8.47 -0.32 1.7e-16 Bipolar disorder and schizophrenia; BRCA cis rs6540559 0.673 rs17015361 chr1:210018901 C/G cg22029157 chr1:209979665 IRF6 0.41 8.05 0.3 4.02e-15 Cleft lip with or without cleft palate; BRCA cis rs367943 0.698 rs9326900 chr5:112972859 A/G cg12552261 chr5:112820674 MCC 0.37 7.88 0.3 1.41e-14 Type 2 diabetes; BRCA cis rs10465746 0.573 rs12121175 chr1:84468961 T/G cg10977910 chr1:84465055 TTLL7 0.53 10.93 0.4 1.34e-25 Obesity-related traits; BRCA cis rs2836974 0.666 rs12626405 chr21:40663121 G/T cg11890956 chr21:40555474 PSMG1 -0.83 -20.96 -0.64 1.2e-74 Cognitive function; BRCA cis rs875971 0.964 rs778735 chr7:65814809 C/A cg11764359 chr7:65958608 NA 0.8 19.34 0.61 5.7e-66 Aortic root size; BRCA cis rs17376456 1.000 rs35184505 chr5:93561535 A/G cg25358565 chr5:93447407 FAM172A 1.23 18.97 0.6 5.19e-64 Diabetic retinopathy; BRCA cis rs7903847 0.620 rs61863815 chr10:99124389 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.34 -0.31 4.45e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg18765753 chr7:1198926 ZFAND2A -0.37 -8.72 -0.33 2.46e-17 Longevity;Endometriosis; BRCA cis rs7618501 0.521 rs868891 chr3:49949071 A/G cg24110177 chr3:50126178 RBM5 -0.51 -14.44 -0.5 3.99e-41 Intelligence (multi-trait analysis); BRCA cis rs372883 0.638 rs117213 chr21:30720536 G/A cg24692254 chr21:30365293 RNF160 -0.49 -11.0 -0.4 6.74e-26 Pancreatic cancer; BRCA cis rs7474896 0.515 rs675628 chr10:38305331 C/G cg25427524 chr10:38739819 LOC399744 0.55 10.12 0.37 1.94e-22 Obesity (extreme); BRCA cis rs2354432 0.607 rs3766524 chr1:146729093 A/G cg25205988 chr1:146714368 CHD1L -0.97 -12.74 -0.45 2.87e-33 Mitochondrial DNA levels; BRCA cis rs4819052 0.851 rs2236446 chr21:46678985 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.56 12.09 0.43 1.89e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg03146154 chr1:46216737 IPP 0.45 10.11 0.37 2.13e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs679087 1.000 rs436124 chr12:29916839 C/T cg14258853 chr12:29935411 TMTC1 0.41 8.74 0.33 2.06e-17 Schizophrenia; BRCA cis rs4891159 0.790 rs8098821 chr18:74140345 T/C cg24786174 chr18:74118243 ZNF516 -0.77 -17.87 -0.58 3.15e-58 Longevity; BRCA cis rs9467773 0.620 rs2451732 chr6:26622904 A/T cg09904177 chr6:26538194 HMGN4 -0.46 -14.48 -0.5 2.68e-41 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.902 rs1165199 chr6:25809087 C/T cg03264133 chr6:25882463 NA -0.49 -11.09 -0.4 3.07e-26 Blood metabolite levels; BRCA trans rs56176327 0.583 rs7613603 chr3:49812866 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.4 8.13 0.31 2.22e-15 Intelligence (multi-trait analysis); BRCA cis rs13102973 0.965 rs6535051 chr4:135874869 G/A cg14419869 chr4:135874104 NA -0.59 -13.0 -0.46 1.93e-34 Subjective well-being; BRCA cis rs17095355 1.000 rs12571872 chr10:111676114 G/A cg00817464 chr10:111662876 XPNPEP1 -0.42 -8.91 -0.33 5.36e-18 Biliary atresia; BRCA cis rs992157 0.717 rs11692780 chr2:219149163 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.53 -11.27 -0.41 5.27e-27 Colorectal cancer; BRCA cis rs9467711 0.591 rs35335639 chr6:26038681 C/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.29 0.35 2.32e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs796364 0.951 rs13029537 chr2:200998950 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.64 -10.7 -0.39 1.09e-24 Schizophrenia; BRCA cis rs2836974 0.568 rs419469 chr21:40537234 C/T cg11890956 chr21:40555474 PSMG1 0.85 21.98 0.66 3.35e-80 Cognitive function; BRCA cis rs546131 0.928 rs553789 chr11:34827579 G/A cg11058730 chr11:34937778 PDHX;APIP 0.43 8.18 0.31 1.58e-15 Lung disease severity in cystic fibrosis; BRCA cis rs17401966 1.000 rs11578788 chr1:10422958 A/G cg03954927 chr1:10346856 KIF1B 0.45 12.54 0.44 1.99e-32 Hepatocellular carcinoma; BRCA cis rs7789940 1.000 rs758944 chr7:75953297 G/T cg10167463 chr7:75959203 YWHAG -0.44 -9.0 -0.34 2.55e-18 Multiple sclerosis; BRCA cis rs780096 0.526 rs4582 chr2:27604279 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -8.99 -0.34 2.8e-18 Total body bone mineral density; BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg07343612 chr16:622815 PIGQ -0.66 -20.87 -0.64 3.96e-74 Height; BRCA cis rs7666738 0.830 rs11721726 chr4:98996314 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.77 0.39 5.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg23958373 chr8:599963 NA -0.65 -8.27 -0.31 7.72e-16 IgG glycosylation; BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.58 -10.84 -0.39 3e-25 Renal function-related traits (BUN); BRCA cis rs7618501 0.521 rs11709573 chr3:49956628 C/T cg14019146 chr3:50243930 SLC38A3 -0.45 -10.94 -0.4 1.24e-25 Intelligence (multi-trait analysis); BRCA cis rs1153858 1.000 rs67831559 chr15:45649307 G/T cg14582100 chr15:45693742 SPATA5L1 0.36 11.67 0.42 1.12e-28 Homoarginine levels; BRCA cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg14844989 chr11:31128820 NA -0.44 -9.4 -0.35 9.4e-20 Red blood cell count; BRCA cis rs4689388 0.679 rs1046316 chr4:6304087 A/G cg25554036 chr4:6271136 WFS1 0.44 9.31 0.35 2.04e-19 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs35306767 0.807 rs12768348 chr10:899224 T/G cg20503657 chr10:835505 NA 1.3 21.76 0.65 5.72e-79 Eosinophil percentage of granulocytes; BRCA cis rs9368481 0.569 rs10946868 chr6:26887930 A/G cg18867708 chr6:26865862 GUSBL1 0.42 8.34 0.31 4.65e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg09184832 chr6:79620586 NA -0.53 -11.62 -0.42 1.85e-28 Intelligence (multi-trait analysis); BRCA cis rs7249142 0.549 rs2283623 chr19:19283027 G/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.48 -11.13 -0.4 2.1e-26 IgG glycosylation; BRCA cis rs11758351 0.587 rs10484436 chr6:26237155 C/T cg01420254 chr6:26195488 NA 0.57 8.75 0.33 1.88e-17 Gout;Renal underexcretion gout; BRCA cis rs2282802 0.660 rs7726176 chr5:139547971 T/A cg26211634 chr5:139558579 C5orf32 -0.34 -8.12 -0.31 2.46e-15 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs3801254 chr7:98010811 G/A cg01877450 chr7:97915802 BRI3 -0.38 -8.55 -0.32 9.39e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs57590327 0.583 rs13062245 chr3:81833718 G/T cg07356753 chr3:81810745 GBE1 -0.48 -11.17 -0.4 1.41e-26 Extraversion; BRCA cis rs7131987 0.874 rs10843366 chr12:29407903 T/C cg09582351 chr12:29534625 ERGIC2 -0.47 -11.56 -0.42 3.34e-28 QT interval; BRCA cis rs9682041 0.696 rs6798399 chr3:170086482 G/A cg11886554 chr3:170076028 SKIL 0.52 10.28 0.38 4.62e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs7727544 0.684 rs272849 chr5:131690241 A/G cg24060327 chr5:131705240 SLC22A5 -0.45 -9.1 -0.34 1.09e-18 Blood metabolite levels; BRCA cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.65e-23 Motion sickness; BRCA cis rs1865760 0.532 rs2006736 chr6:26086017 C/T cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg23625390 chr15:77176239 SCAPER 0.35 7.97 0.3 7.24e-15 Blood metabolite levels; BRCA cis rs270601 0.721 rs270621 chr5:131605821 C/A cg11843238 chr5:131593191 PDLIM4 0.4 9.49 0.35 4.53e-20 Acylcarnitine levels; BRCA cis rs3806843 0.735 rs801167 chr5:140081423 A/G cg26395211 chr5:140044315 WDR55 -0.38 -8.6 -0.32 5.99e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs7249142 0.527 rs12975096 chr19:19279409 G/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.41 -8.87 -0.33 7.45e-18 IgG glycosylation; BRCA cis rs3818285 0.556 rs941864 chr10:111656948 T/C cg00817464 chr10:111662876 XPNPEP1 -0.37 -9.91 -0.36 1.26e-21 Superior crus of antihelix expression; BRCA cis rs2878628 0.596 rs57039206 chr3:52758570 T/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.32 0.41 3.45e-27 Intelligence (multi-trait analysis); BRCA cis rs13082711 0.871 rs73046194 chr3:27454558 C/T cg02860705 chr3:27208620 NA 0.53 10.56 0.39 3.99e-24 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA trans rs11098499 0.954 rs35063680 chr4:120387102 T/C cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs4481887 0.745 rs4540687 chr1:248476099 C/G cg00666640 chr1:248458726 OR2T12 0.32 8.77 0.33 1.63e-17 Common traits (Other); BRCA cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg08999081 chr20:33150536 PIGU -0.46 -12.73 -0.45 3.12e-33 Glomerular filtration rate (creatinine); BRCA cis rs1008375 0.966 rs758483 chr4:17703614 G/T cg02297831 chr4:17616191 MED28 -0.36 -8.21 -0.31 1.22e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9868809 0.505 rs11706983 chr3:48738678 A/G cg07636037 chr3:49044803 WDR6 -0.57 -7.87 -0.3 1.52e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs4803468 0.934 rs11880674 chr19:41889423 A/T cg09537434 chr19:41945824 ATP5SL -0.99 -23.84 -0.69 2.47e-90 Height; BRCA cis rs826838 0.586 rs10880753 chr12:38628147 C/A cg26384229 chr12:38710491 ALG10B -0.45 -10.34 -0.38 2.73e-23 Heart rate; BRCA cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg23711669 chr6:146136114 FBXO30 0.73 16.97 0.56 1.39e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg03188948 chr7:1209495 NA 0.87 11.85 0.42 2.11e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.590 rs13019536 chr2:26526978 C/A cg27170947 chr2:26402098 FAM59B -0.6 -10.88 -0.4 2.05e-25 Gut microbiome composition (summer); BRCA cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.2 0.34 5.22e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs250677 0.522 rs12520924 chr5:148349149 C/T cg18129178 chr5:148520854 ABLIM3 0.54 10.33 0.38 2.95e-23 Breast cancer; BRCA cis rs13118159 0.767 rs2141656 chr4:1317192 C/T cg20887711 chr4:1340912 KIAA1530 0.41 10.01 0.37 5.27e-22 Longevity; BRCA cis rs6582630 0.638 rs12231073 chr12:38526901 T/G cg26384229 chr12:38710491 ALG10B -0.46 -10.66 -0.39 1.51e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs9790314 0.718 rs6774635 chr3:160847908 A/G cg04691961 chr3:161091175 C3orf57 -0.46 -9.95 -0.37 8.57e-22 Morning vs. evening chronotype; BRCA cis rs7772486 0.686 rs1292334 chr6:145968288 A/G cg23711669 chr6:146136114 FBXO30 0.77 18.29 0.59 2.05e-60 Lobe attachment (rater-scored or self-reported); BRCA cis rs881375 0.678 rs7037195 chr9:123684000 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.57 0.32 7.48e-17 Rheumatoid arthritis; BRCA cis rs735396 1.000 rs1169311 chr12:121440731 C/T cg02403541 chr12:121454288 C12orf43 0.53 9.98 0.37 7.02e-22 N-glycan levels; BRCA cis rs1348850 0.874 rs1348848 chr2:178358233 A/C cg02961200 chr2:178257176 LOC100130691;AGPS -0.49 -10.31 -0.38 3.81e-23 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.79 13.08 0.46 8.17e-35 Platelet count; BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg12311346 chr5:56204834 C5orf35 -0.78 -15.64 -0.53 6.56e-47 Initial pursuit acceleration; BRCA cis rs7666738 0.515 rs13142498 chr4:98792443 G/T cg05340658 chr4:99064831 C4orf37 0.56 10.8 0.39 4.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9487051 0.646 rs11153166 chr6:109622494 C/T cg01475377 chr6:109611718 NA 0.39 8.65 0.32 4.28e-17 Reticulocyte fraction of red cells; BRCA cis rs1008375 0.646 rs13145480 chr4:17565143 T/C cg16339924 chr4:17578868 LAP3 -0.55 -12.62 -0.45 9.1e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs1493916 0.592 rs1389068 chr18:31312738 G/T cg15819921 chr19:927150 ARID3A -0.43 -8.17 -0.31 1.61e-15 Life satisfaction; BRCA cis rs6964587 0.967 rs10279210 chr7:91616891 G/A cg17063962 chr7:91808500 NA 0.57 13.54 0.47 6.61e-37 Breast cancer; BRCA cis rs12478296 0.792 rs6740738 chr2:243007368 A/C cg18898632 chr2:242989856 NA -0.47 -8.1 -0.31 2.85e-15 Obesity-related traits; BRCA cis rs6684428 0.611 rs6657176 chr1:56328238 G/T cg11651538 chr1:56320950 NA -0.41 -7.96 -0.3 7.67e-15 Airflow obstruction; BRCA cis rs56104184 0.723 rs1058483 chr19:49407660 G/A cg21252483 chr19:49399788 TULP2 -0.52 -11.3 -0.41 3.95e-27 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs9815354 0.597 rs17283481 chr3:41924015 T/C cg03022575 chr3:42003672 ULK4 0.71 9.74 0.36 5.4e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg22496339 chr2:162101262 NA 0.44 9.07 0.34 1.42e-18 Intelligence (multi-trait analysis); BRCA cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg19622623 chr12:86230825 RASSF9 -0.29 -8.18 -0.31 1.57e-15 Major depressive disorder; BRCA cis rs61931739 0.517 rs2636073 chr12:34063049 C/T cg06521331 chr12:34319734 NA -0.62 -12.41 -0.44 8.14e-32 Morning vs. evening chronotype; BRCA cis rs13191362 0.872 rs13213421 chr6:163203805 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.97 14.94 0.51 1.6e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1883415 0.534 rs2760143 chr6:24479472 C/T cg20631270 chr6:24437470 GPLD1 0.4 8.16 0.31 1.78e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10242455 0.702 rs55927283 chr7:99057191 G/C cg18809830 chr7:99032528 PTCD1 -0.56 -8.34 -0.31 4.49e-16 Blood metabolite levels; BRCA cis rs9858542 0.953 rs1873625 chr3:49666964 C/A cg03060546 chr3:49711283 APEH -0.56 -11.23 -0.41 7.67e-27 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs847649 0.842 rs7789252 chr7:102624227 C/A cg18108683 chr7:102477205 FBXL13 -0.42 -9.86 -0.36 1.9e-21 Morning vs. evening chronotype; BRCA cis rs1635 0.512 rs73742545 chr6:28319023 T/G cg15743358 chr6:28303923 ZNF323 -0.76 -8.86 -0.33 8.09e-18 Schizophrenia; BRCA cis rs1538970 0.962 rs7532762 chr1:45864695 C/A cg05343316 chr1:45956843 TESK2 0.55 11.51 0.41 5.57e-28 Platelet count; BRCA cis rs3741404 1.000 rs3741404 chr11:63999240 G/C cg18225595 chr11:63971243 STIP1 0.51 12.08 0.43 2.16e-30 Platelet count; BRCA trans rs61931739 0.500 rs73103774 chr12:34482279 C/T cg26384229 chr12:38710491 ALG10B 0.74 16.52 0.55 2.57e-51 Morning vs. evening chronotype; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg08132940 chr7:1081526 C7orf50 -0.59 -8.84 -0.33 9.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs524281 0.861 rs9645684 chr11:65907964 G/A cg16950941 chr11:66035639 RAB1B -0.38 -8.01 -0.3 5.32e-15 Electroencephalogram traits; BRCA cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg22105103 chr4:187893119 NA -0.33 -10.32 -0.38 3.46e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs77972916 0.505 rs6727824 chr2:43528377 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.69 -11.61 -0.42 2.12e-28 Granulocyte percentage of myeloid white cells; BRCA cis rs10045504 0.502 rs72746054 chr5:38762351 C/T cg15396434 chr5:38725168 NA -0.56 -10.69 -0.39 1.23e-24 Night sleep phenotypes; BRCA trans rs9858542 0.953 rs9827708 chr3:49649989 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.87 -0.36 1.83e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2019137 0.967 rs902695 chr2:113955074 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.61 -13.09 -0.46 7.5e-35 Lymphocyte counts; BRCA cis rs7584330 0.868 rs2325839 chr2:238386286 T/C cg11271282 chr2:238384023 NA 0.49 9.08 0.34 1.36e-18 Prostate cancer; BRCA cis rs3936840 0.964 rs10150698 chr14:102977876 A/G cg18135206 chr14:102964638 TECPR2 0.64 14.18 0.49 7.25e-40 Plateletcrit; BRCA cis rs7737355 0.741 rs6875363 chr5:130581195 A/G cg06307176 chr5:131281290 NA -0.45 -8.31 -0.31 5.8e-16 Life satisfaction; BRCA cis rs17376456 0.877 rs17316137 chr5:93456577 C/T cg21475434 chr5:93447410 FAM172A 0.67 9.02 0.34 2.19e-18 Diabetic retinopathy; BRCA cis rs13046373 0.535 rs8129571 chr21:31980646 G/A cg16431978 chr21:31797932 KRTAP13-3 0.36 9.17 0.34 6.19e-19 HDL cholesterol; BRCA cis rs965469 0.779 rs6133034 chr20:3337661 A/G cg25506879 chr20:3388711 C20orf194 -0.44 -8.77 -0.33 1.66e-17 IFN-related cytopenia; BRCA cis rs7520050 0.966 rs785485 chr1:46574424 C/T cg24296786 chr1:45957014 TESK2 0.41 9.02 0.34 2.21e-18 Red blood cell count;Reticulocyte count; BRCA cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.755 rs4819270 chr21:45020919 G/A cg01579765 chr21:45077557 HSF2BP -0.42 -11.27 -0.41 5.51e-27 Mean corpuscular volume; BRCA cis rs7000551 0.715 rs7839577 chr8:22307325 T/A cg12081754 chr8:22256438 SLC39A14 0.39 7.84 0.3 1.86e-14 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9463078 0.874 rs2093901 chr6:45177315 C/G cg25276700 chr6:44698697 NA -0.36 -8.02 -0.3 5.18e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9790314 0.905 rs1154701 chr3:161008025 T/A cg03342759 chr3:160939853 NMD3 -0.66 -14.31 -0.49 1.77e-40 Morning vs. evening chronotype; BRCA cis rs270601 0.690 rs162907 chr5:131580152 A/G cg09877947 chr5:131593287 PDLIM4 -0.42 -10.06 -0.37 3.26e-22 Acylcarnitine levels; BRCA cis rs933688 1.000 rs10073935 chr5:90742188 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.92 21.17 0.64 8.76e-76 Smoking behavior; BRCA cis rs62064224 0.560 rs12162135 chr17:30805795 A/C cg18200150 chr17:30822561 MYO1D 0.56 16.9 0.56 2.94e-53 Schizophrenia; BRCA cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg03517284 chr6:25882590 NA -0.48 -10.29 -0.38 4.45e-23 Intelligence (multi-trait analysis); BRCA cis rs6728642 1.000 rs113863815 chr2:97657813 A/G cg26665480 chr2:98280029 ACTR1B -0.67 -7.86 -0.3 1.65e-14 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs7666738 0.830 rs17484890 chr4:99013778 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.04e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 1.000 rs28173 chr5:148423573 C/T cg12140854 chr5:148520817 ABLIM3 -0.42 -9.05 -0.34 1.71e-18 Breast cancer; BRCA trans rs561341 1.000 rs8073186 chr17:30244956 T/C cg27661571 chr11:113659931 NA -0.53 -8.93 -0.33 4.64e-18 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.830 rs3857217 chr4:99034347 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4481887 0.927 rs6666903 chr1:248465582 T/A cg00666640 chr1:248458726 OR2T12 0.31 8.55 0.32 8.95e-17 Common traits (Other); BRCA cis rs2243480 0.901 rs73142137 chr7:65343442 A/T cg18252515 chr7:66147081 NA -0.87 -12.08 -0.43 2.13e-30 Diabetic kidney disease; BRCA cis rs7799006 0.929 rs7781856 chr7:2257199 C/T cg08027265 chr7:2291960 NA -0.4 -9.94 -0.37 9.92e-22 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs3858526 0.959 rs1840179 chr11:5949148 A/G cg05234568 chr11:5960015 NA -0.5 -9.63 -0.36 1.43e-20 DNA methylation (variation); BRCA cis rs910316 0.967 rs12147532 chr14:75651858 T/G cg11812906 chr14:75593930 NEK9 -0.56 -12.55 -0.44 1.96e-32 Height; BRCA cis rs2836950 0.545 rs2836959 chr21:40623668 T/G cg11644478 chr21:40555479 PSMG1 -0.53 -11.31 -0.41 3.72e-27 Menarche (age at onset); BRCA cis rs7267979 1.000 rs2258135 chr20:25272323 C/A cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.8 0.36 3.22e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1552244 0.816 rs56387520 chr3:10042782 C/T cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg09658497 chr7:2847517 GNA12 -0.46 -10.05 -0.37 3.75e-22 Height; BRCA trans rs3808502 0.525 rs9650661 chr8:11427133 G/T cg08975724 chr8:8085496 FLJ10661 -0.39 -7.96 -0.3 7.72e-15 Neuroticism; BRCA cis rs41005 1.000 rs41008 chr2:8108588 G/T cg03155496 chr2:8117019 LOC339788 0.57 15.11 0.51 2.38e-44 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs1005277 0.540 rs1987431 chr10:37988887 T/C cg25427524 chr10:38739819 LOC399744 -0.65 -15.63 -0.53 7.26e-47 Extrinsic epigenetic age acceleration; BRCA cis rs546131 0.928 rs535719 chr11:34853382 A/G cg11058730 chr11:34937778 PDHX;APIP 0.47 8.77 0.33 1.63e-17 Lung disease severity in cystic fibrosis; BRCA cis rs1215050 0.755 rs6851840 chr4:98776366 A/G cg05340658 chr4:99064831 C4orf37 0.44 10.14 0.37 1.74e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs13006833 0.668 rs2582746 chr2:191163784 T/C cg27211696 chr2:191398769 TMEM194B 0.36 7.87 0.3 1.57e-14 Urinary metabolites; BRCA cis rs12474201 0.832 rs4952843 chr2:46957845 A/G cg06386533 chr2:46925753 SOCS5 0.87 19.14 0.6 7.24e-65 Height; BRCA trans rs6582630 0.519 rs2387812 chr12:38381480 A/G cg06521331 chr12:34319734 NA -0.43 -8.12 -0.31 2.41e-15 Drug-induced liver injury (flucloxacillin); BRCA cis rs765787 0.530 rs4444275 chr15:45535347 T/C cg24006582 chr15:45444508 DUOX1 -0.55 -11.32 -0.41 3.19e-27 Uric acid levels; BRCA trans rs7618501 0.633 rs6446193 chr3:50059758 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.3 -8.29 -0.31 6.44e-16 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.905 rs1355146 chr6:145781741 A/C cg23711669 chr6:146136114 FBXO30 -0.62 -14.09 -0.49 1.95e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649213 0.555 rs6968193 chr7:97915902 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.17 0.43 8.41e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs35110281 0.627 rs56369437 chr21:44970275 A/G cg21573476 chr21:45109991 RRP1B -0.34 -8.71 -0.33 2.58e-17 Mean corpuscular volume; BRCA cis rs2882667 0.690 rs288038 chr5:138207533 G/A cg04439458 chr5:138467593 SIL1 -0.31 -7.94 -0.3 8.86e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4240897 0.835 rs4845891 chr1:12042506 T/C cg13216073 chr1:12042593 MFN2 0.56 13.64 0.47 2.25e-37 Tuberculosis; BRCA cis rs67478160 0.595 rs12433109 chr14:104196607 G/A cg26031613 chr14:104095156 KLC1 -0.46 -8.79 -0.33 1.39e-17 Schizophrenia; BRCA cis rs6570726 0.791 rs12208019 chr6:145935572 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.03 0.3 4.76e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs8141529 0.748 rs5762881 chr22:29289346 C/A cg15103426 chr22:29168792 CCDC117 0.51 11.9 0.43 1.18e-29 Lymphocyte counts; BRCA cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg11301795 chr4:187892539 NA -0.27 -8.71 -0.33 2.5e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs3806843 0.966 rs11953833 chr5:140155123 T/A cg11822812 chr5:140052017 DND1 0.31 8.46 0.32 1.85e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs10046574 0.831 rs7455447 chr7:135062056 C/T cg27474649 chr7:135195673 CNOT4 0.57 8.01 0.3 5.31e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7811142 0.775 rs6946768 chr7:99954393 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -11.59 -0.42 2.62e-28 Platelet count; BRCA cis rs11758351 0.866 rs2069019 chr6:26205604 C/T cg01420254 chr6:26195488 NA 0.56 8.65 0.32 4.11e-17 Gout;Renal underexcretion gout; BRCA cis rs3793683 0.928 rs2148666 chr10:134553785 A/G cg18305652 chr10:134549665 INPP5A 0.3 8.87 0.33 7.35e-18 Migraine; BRCA cis rs1971762 0.602 rs4759283 chr12:54079243 C/T cg23533419 chr12:54090519 NA -0.33 -8.3 -0.31 6.17e-16 Height; BRCA cis rs7246657 0.722 rs2972430 chr19:38182111 C/T cg18154014 chr19:37997991 ZNF793 -0.51 -9.64 -0.36 1.27e-20 Coronary artery calcification; BRCA cis rs6088580 0.634 rs13041646 chr20:33082881 T/A cg06115741 chr20:33292138 TP53INP2 0.36 8.01 0.3 5.54e-15 Glomerular filtration rate (creatinine); BRCA cis rs12464559 0.522 rs7583060 chr2:152620943 C/A cg01189475 chr2:152685088 ARL5A 0.61 9.3 0.35 2.12e-19 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs7666738 0.830 rs17550630 chr4:99008332 G/T cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.8e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs6426558 0.572 rs2670471 chr1:227454328 T/C cg10327440 chr1:227177885 CDC42BPA 0.48 9.66 0.36 1.07e-20 Neutrophil percentage of white cells; BRCA cis rs7640424 0.750 rs13074183 chr3:107851467 G/A cg09227934 chr3:107805635 CD47 -0.43 -9.01 -0.34 2.29e-18 Body mass index; BRCA cis rs3772130 1.000 rs56314138 chr3:121356656 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.49 0.35 4.34e-20 Cognitive performance; BRCA trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg23505145 chr19:12996616 KLF1 0.56 12.79 0.45 1.66e-33 Prostate cancer (SNP x SNP interaction); BRCA trans rs11098499 0.954 rs10017543 chr4:120321420 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.96 0.3 7.89e-15 Corneal astigmatism; BRCA cis rs7666738 0.830 rs4699584 chr4:98952019 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg24562669 chr7:97807699 LMTK2 0.44 11.75 0.42 5.51e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs6598955 0.671 rs10159433 chr1:26618370 A/G cg00852783 chr1:26633632 UBXN11 -0.47 -8.34 -0.31 4.72e-16 Obesity-related traits; BRCA cis rs3733585 0.725 rs10939636 chr4:9972640 T/G cg00071950 chr4:10020882 SLC2A9 -0.43 -10.03 -0.37 4.28e-22 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs12517041 1.000 rs4701365 chr5:23315034 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.47 -8.11 -0.31 2.55e-15 Calcium levels; BRCA cis rs637571 0.522 rs491973 chr11:65727301 A/G cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 9.89 0.36 1.52e-21 Eosinophil percentage of white cells; BRCA cis rs7589728 0.514 rs74426843 chr2:88459388 C/T cg14558114 chr2:88469736 THNSL2 0.63 9.15 0.34 7.55e-19 Plasma clusterin levels; BRCA cis rs7246657 0.943 rs10417844 chr19:37837587 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.56 0.35 2.54e-20 Coronary artery calcification; BRCA cis rs1577917 0.958 rs4707236 chr6:86583967 A/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.22 -0.41 8.84e-27 Response to antipsychotic treatment; BRCA cis rs2652822 0.933 rs7170846 chr15:63449543 A/C cg02713581 chr15:63449717 RPS27L 0.49 10.07 0.37 3.21e-22 Metabolic traits; BRCA trans rs11088226 0.681 rs1015048 chr21:33949306 T/C cg09050820 chr6:167586206 TCP10L2 0.85 15.85 0.53 5.9e-48 Gastritis; BRCA cis rs1707322 1.000 rs7539800 chr1:46262129 C/G cg03146154 chr1:46216737 IPP -0.5 -10.83 -0.39 3.15e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3733585 0.781 rs13103879 chr4:9972879 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -9.93 -0.37 1.06e-21 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs3857536 0.740 rs9342532 chr6:66886297 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.49 -9.77 -0.36 4.07e-21 Blood trace element (Cu levels); BRCA cis rs12479064 0.724 rs737094 chr2:100089078 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -11.75 -0.42 5.1e-29 Chronic sinus infection; BRCA cis rs4363385 0.818 rs377768 chr1:153016594 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.46 -0.32 1.88e-16 Inflammatory skin disease; BRCA cis rs586533 0.813 rs2458166 chr11:99500840 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7772486 0.790 rs9403749 chr6:146162239 A/G cg23711669 chr6:146136114 FBXO30 0.83 20.4 0.63 1.24e-71 Lobe attachment (rater-scored or self-reported); BRCA cis rs250677 1.000 rs36080 chr5:148430451 A/G cg23229984 chr5:148520753 ABLIM3 0.31 7.84 0.3 1.92e-14 Breast cancer; BRCA cis rs57221529 0.766 rs72703064 chr5:587825 T/C cg09021430 chr5:549028 NA -0.68 -14.14 -0.49 1.07e-39 Lung disease severity in cystic fibrosis; BRCA cis rs6831352 0.918 rs13138294 chr4:100062675 T/G cg12011299 chr4:100065546 ADH4 -0.51 -11.64 -0.42 1.56e-28 Alcohol dependence; BRCA cis rs7737355 0.947 rs6879005 chr5:130615445 C/T cg06307176 chr5:131281290 NA 0.46 8.97 0.33 3.29e-18 Life satisfaction; BRCA cis rs8114671 0.628 rs6060130 chr20:33549319 C/T cg07148914 chr20:33460835 GGT7 0.45 9.67 0.36 1.02e-20 Height; BRCA cis rs6598955 0.671 rs11247900 chr1:26612460 G/A cg00852783 chr1:26633632 UBXN11 -0.47 -8.5 -0.32 1.31e-16 Obesity-related traits; BRCA cis rs9399135 0.622 rs3817776 chr6:135256756 C/T cg22676075 chr6:135203613 NA -0.43 -9.05 -0.34 1.71e-18 Red blood cell count; BRCA cis rs4808199 0.948 rs8108647 chr19:19427623 A/G cg01262667 chr19:19385393 TM6SF2 0.39 8.01 0.3 5.51e-15 Nonalcoholic fatty liver disease; BRCA cis rs7267979 0.932 rs367666 chr20:25449818 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.25 0.34 3.25e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg17971929 chr21:40555470 PSMG1 0.8 18.56 0.59 8.04e-62 Cognitive function; BRCA cis rs12497850 0.864 rs6779394 chr3:49157771 G/A cg06212747 chr3:49208901 KLHDC8B 0.51 10.25 0.38 6.36e-23 Parkinson's disease; BRCA cis rs9487051 0.735 rs419106 chr6:109520067 C/G cg01475377 chr6:109611718 NA -0.47 -11.93 -0.43 9.51e-30 Reticulocyte fraction of red cells; BRCA cis rs10504229 1.000 rs17805602 chr8:58179915 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.34 0.31 4.42e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72634258 0.554 rs35307738 chr1:7919839 C/G cg00042356 chr1:8021962 PARK7 0.53 8.31 0.31 5.8e-16 Inflammatory bowel disease; BRCA trans rs1005277 0.541 rs2263163 chr10:38389887 G/A cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs10754283 0.967 rs6698273 chr1:90106791 T/A cg21401794 chr1:90099060 LRRC8C 0.46 11.13 0.4 2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs2455601 0.573 rs2653573 chr11:8989874 C/G cg21881798 chr11:8931708 C11orf17;ST5 -0.44 -8.37 -0.31 3.72e-16 Schizophrenia; BRCA cis rs7666738 0.830 rs4334758 chr4:98971875 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.887 rs4665814 chr2:26273687 G/T cg27170947 chr2:26402098 FAM59B -0.64 -11.48 -0.41 7.44e-28 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg22535103 chr8:58192502 C8orf71 -0.47 -9.24 -0.34 3.68e-19 Developmental language disorder (linguistic errors); BRCA cis rs4076764 1.000 rs7540279 chr1:163429970 A/T cg24596788 chr1:163392923 NA -0.37 -9.61 -0.36 1.61e-20 Motion sickness; BRCA cis rs6426558 0.537 rs4500279 chr1:227484482 G/A cg10327440 chr1:227177885 CDC42BPA 0.47 9.46 0.35 5.83e-20 Neutrophil percentage of white cells; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg26314531 chr2:26401878 FAM59B -0.64 -11.13 -0.4 2.02e-26 Gut microbiome composition (summer); BRCA cis rs7412746 0.658 rs8444 chr1:150938571 G/A cg15448220 chr1:150897856 SETDB1 0.36 8.06 0.3 3.83e-15 Melanoma; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg12016809 chr21:47604291 C21orf56 -0.4 -7.92 -0.3 1.08e-14 Testicular germ cell tumor; BRCA cis rs13272623 0.502 rs268599 chr8:71517401 G/T cg23757474 chr8:71581111 LACTB2;XKR9 -0.44 -9.31 -0.35 1.98e-19 IgG glycosylation; BRCA cis rs769267 0.930 rs10282 chr19:19619317 T/C cg03709012 chr19:19516395 GATAD2A 0.81 19.06 0.6 1.89e-64 Tonsillectomy; BRCA trans rs9858542 1.000 rs9858542 chr3:49701983 A/G cg21659725 chr3:3221576 CRBN 0.45 9.42 0.35 8.42e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs873946 0.648 rs1543593 chr10:134553185 A/T cg18305652 chr10:134549665 INPP5A 0.5 11.55 0.42 3.89e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg12311346 chr5:56204834 C5orf35 -0.81 -16.08 -0.54 4.04e-49 Initial pursuit acceleration; BRCA trans rs9784649 1.000 rs56004901 chr5:24998968 A/G cg08600765 chr20:34638493 LOC647979 -0.52 -8.65 -0.32 4e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs13191362 1.000 rs36107456 chr6:162997399 T/G cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.37 0.41 2.13e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs35110281 0.744 rs162395 chr21:44945759 T/C cg21573476 chr21:45109991 RRP1B -0.35 -8.84 -0.33 9.44e-18 Mean corpuscular volume; BRCA cis rs68170813 0.559 rs3801958 chr7:106961139 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.52 -0.32 1.17e-16 Coronary artery disease; BRCA cis rs12464483 0.524 rs4952173 chr2:30888346 G/T cg12454169 chr2:30669597 LCLAT1 0.5 9.22 0.34 4.26e-19 Pre-treatment pain in head and neck squamous cell carcinoma; BRCA cis rs3784262 0.631 rs4646625 chr15:58256296 C/T cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.03 -0.37 4.51e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7092929 0.941 rs575738 chr10:3579283 C/A cg14308648 chr10:3568949 NA 0.45 8.13 0.31 2.25e-15 Coronary artery calcification; BRCA cis rs2243480 1.000 rs451396 chr7:65484074 T/A cg18252515 chr7:66147081 NA -0.88 -12.64 -0.45 7.81e-33 Diabetic kidney disease; BRCA cis rs6424115 0.964 rs2473375 chr1:24136545 C/T cg15997130 chr1:24165203 NA 0.55 14.67 0.5 3.13e-42 Immature fraction of reticulocytes; BRCA cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg17143192 chr8:8559678 CLDN23 0.58 11.28 0.41 5.1e-27 Obesity-related traits; BRCA cis rs2204008 0.837 rs8189467 chr12:38241956 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.04 0.51 5.67e-44 Bladder cancer; BRCA cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg09184832 chr6:79620586 NA -0.52 -11.62 -0.42 1.83e-28 Intelligence (multi-trait analysis); BRCA cis rs6547741 1.000 rs6706610 chr2:27778091 G/A cg27432699 chr2:27873401 GPN1 0.47 9.87 0.36 1.81e-21 Oral cavity cancer; BRCA cis rs12762955 0.561 rs7075141 chr10:1091195 C/T cg26597838 chr10:835615 NA -0.42 -8.47 -0.32 1.73e-16 Response to angiotensin II receptor blocker therapy; BRCA cis rs2762353 0.935 rs1177442 chr6:25809069 A/G cg03517284 chr6:25882590 NA -0.47 -10.71 -0.39 9.52e-25 Blood metabolite levels; BRCA cis rs7772486 0.846 rs2144478 chr6:146381445 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.74 0.5 1.61e-42 Lobe attachment (rater-scored or self-reported); BRCA trans rs3733585 0.699 rs7683283 chr4:9969974 T/C cg26043149 chr18:55253948 FECH -0.37 -8.19 -0.31 1.42e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg01579765 chr21:45077557 HSF2BP -0.44 -12.09 -0.43 1.87e-30 Mean corpuscular volume; BRCA cis rs35110281 0.693 rs11089093 chr21:45121161 C/T cg04455712 chr21:45112962 RRP1B 0.41 11.02 0.4 5.51e-26 Mean corpuscular volume; BRCA cis rs7903847 0.692 rs7900255 chr10:99157575 G/A cg08345082 chr10:99160200 RRP12 -0.3 -8.7 -0.33 2.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs7677751 0.806 rs4864860 chr4:55090021 T/C cg17187183 chr4:55093834 PDGFRA 0.44 9.35 0.35 1.48e-19 Corneal astigmatism; BRCA cis rs7264396 0.563 rs2425116 chr20:34323553 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs3820928 0.874 rs10439363 chr2:227815065 C/T cg11843606 chr2:227700838 RHBDD1 -0.4 -8.8 -0.33 1.23e-17 Pulmonary function; BRCA trans rs9650657 0.803 rs13276026 chr8:10609955 G/A cg15556689 chr8:8085844 FLJ10661 -0.29 -7.92 -0.3 1.06e-14 Neuroticism; BRCA cis rs9469578 0.792 rs73743331 chr6:33714036 G/T cg18708504 chr6:33715942 IP6K3 0.7 10.23 0.38 7.52e-23 Phosphorus levels; BRCA cis rs28374715 0.532 rs28703570 chr15:41679492 G/A cg18705301 chr15:41695430 NDUFAF1 -1.09 -28.05 -0.74 1.79e-113 Ulcerative colitis; BRCA cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.49 -0.44 3.52e-32 Bipolar disorder; BRCA cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg20891558 chr2:74357851 NA 0.63 12.62 0.45 9.49e-33 Gestational age at birth (maternal effect); BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg12648201 chr2:27665141 KRTCAP3 -0.33 -8.08 -0.3 3.21e-15 Total body bone mineral density; BRCA cis rs2204008 0.744 rs11168870 chr12:37973333 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.13 0.37 1.89e-22 Bladder cancer; BRCA cis rs769267 0.896 rs2074298 chr19:19377716 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.4 9.42 0.35 7.94e-20 Tonsillectomy; BRCA cis rs4660306 0.961 rs2991966 chr1:45999503 G/A cg24296786 chr1:45957014 TESK2 0.44 8.77 0.33 1.58e-17 Homocysteine levels; BRCA cis rs9291683 1.000 rs9291683 chr4:10324160 C/T cg11266682 chr4:10021025 SLC2A9 0.4 10.57 0.39 3.65e-24 Bone mineral density; BRCA cis rs4722404 0.502 rs13223548 chr7:3110446 T/C cg19214707 chr7:3157722 NA -0.37 -7.81 -0.3 2.44e-14 Atopic dermatitis; BRCA cis rs1865760 1.000 rs6910138 chr6:25904352 C/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.34 0.38 2.87e-23 Height; BRCA cis rs6430585 0.583 rs58509842 chr2:136586027 G/A cg07169764 chr2:136633963 MCM6 1.25 30.25 0.77 1.89e-125 Corneal structure; BRCA cis rs7829975 0.564 rs2976855 chr8:8301794 G/A cg15556689 chr8:8085844 FLJ10661 0.5 14.26 0.49 2.8e-40 Mood instability; BRCA cis rs523522 0.962 rs7136951 chr12:120941927 C/T cg27279351 chr12:120934652 DYNLL1 0.51 12.39 0.44 9.44e-32 High light scatter reticulocyte count; BRCA cis rs10504229 0.683 rs11774645 chr8:58132921 G/C cg08219700 chr8:58056026 NA 0.57 9.48 0.35 4.72e-20 Developmental language disorder (linguistic errors); BRCA cis rs6867032 0.958 rs9312970 chr5:2002415 C/A cg26168224 chr5:2018326 NA -0.61 -15.84 -0.53 6.79e-48 Gut microbiome composition (winter); BRCA cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg18876405 chr7:65276391 NA 0.5 11.07 0.4 3.5e-26 Aortic root size; BRCA cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.36e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7772486 0.701 rs11155438 chr6:145950112 C/G cg23711669 chr6:146136114 FBXO30 0.79 19.09 0.6 1.27e-64 Lobe attachment (rater-scored or self-reported); BRCA trans rs7819412 0.502 rs4841499 chr8:10988138 A/C cg06636001 chr8:8085503 FLJ10661 -0.45 -8.17 -0.31 1.63e-15 Triglycerides; BRCA cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.24 -0.31 9.65e-16 Bipolar disorder; BRCA cis rs4803455 0.565 rs2241713 chr19:41869468 C/G cg09537434 chr19:41945824 ATP5SL 0.61 12.69 0.45 4.73e-33 Migraine;Coronary artery disease; BRCA cis rs782590 0.683 rs782633 chr2:55898203 A/G cg18811423 chr2:55921094 PNPT1 0.78 26.62 0.73 1.31e-105 Metabolic syndrome; BRCA cis rs6570726 0.935 rs385185 chr6:145814992 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.05 0.51 4.81e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.49 9.77 0.36 4.08e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs877282 0.853 rs11253332 chr10:755262 G/C cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs7824557 0.603 rs6995404 chr8:11182148 C/G cg21775007 chr8:11205619 TDH 0.68 15.93 0.53 2.47e-48 Retinal vascular caliber; BRCA cis rs514406 0.505 rs387436 chr1:53179376 C/T cg08859206 chr1:53392774 SCP2 0.43 8.69 0.33 2.94e-17 Monocyte count; BRCA cis rs9462846 0.881 rs34498470 chr6:42879551 C/T cg05552183 chr6:42928497 GNMT 0.45 7.99 0.3 6.17e-15 Blood protein levels; BRCA trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.62 0.36 1.5e-20 Morning vs. evening chronotype; BRCA cis rs11893307 0.599 rs12617417 chr2:191663571 C/G cg05765582 chr2:191677683 NA 0.44 8.06 0.3 3.77e-15 Mean platelet volume; BRCA cis rs758324 0.853 rs6865911 chr5:131204659 A/G cg06307176 chr5:131281290 NA 0.53 10.2 0.37 9.83e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs9381040 1.000 rs2093395 chr6:41155026 C/G cg04346459 chr6:41068666 NFYA;LOC221442 0.4 8.39 0.31 3.17e-16 Alzheimer's disease (late onset); BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg07930192 chr7:1003750 NA 0.41 8.81 0.33 1.17e-17 Longevity;Endometriosis; BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg18765753 chr7:1198926 ZFAND2A -0.4 -7.96 -0.3 7.85e-15 Bronchopulmonary dysplasia; BRCA cis rs9443645 0.901 rs1890229 chr6:79695029 C/T cg09184832 chr6:79620586 NA -0.52 -11.36 -0.41 2.37e-27 Intelligence (multi-trait analysis); BRCA cis rs12367572 0.580 rs1495034 chr12:45414203 C/T cg04608330 chr12:45269318 NELL2 -0.4 -8.64 -0.32 4.52e-17 Gut microbiome composition (summer); BRCA cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.95 14.38 0.49 8.38e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs1941687 0.509 rs6507060 chr18:31322278 C/T cg15819921 chr19:927150 ARID3A 0.44 8.37 0.31 3.54e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs1552244 1.000 rs113522867 chr3:10154503 T/C cg10729496 chr3:10149963 C3orf24 0.49 9.41 0.35 8.99e-20 Alzheimer's disease; BRCA trans rs11098499 0.909 rs28555550 chr4:120211040 C/G cg25214090 chr10:38739885 LOC399744 0.5 10.94 0.4 1.2e-25 Corneal astigmatism; BRCA cis rs870825 0.616 rs6552807 chr4:185640531 A/G cg04058563 chr4:185651563 MLF1IP 0.76 16.76 0.55 1.57e-52 Blood protein levels; BRCA cis rs12142240 0.660 rs72890715 chr1:46852077 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg05457628 chr5:178986728 RUFY1 0.54 12.46 0.44 4.7e-32 Lung cancer; BRCA cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.62 -0.32 5.09e-17 Aortic root size; BRCA cis rs11764590 0.694 rs55860148 chr7:2105594 G/A cg23422044 chr7:1970798 MAD1L1 -0.5 -9.53 -0.35 3.12e-20 Neuroticism; BRCA cis rs2739330 0.796 rs1006771 chr22:24314006 G/T cg10150615 chr22:24372951 LOC391322 -0.42 -9.27 -0.34 2.88e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2777491 1.000 rs316610 chr15:41752852 C/T cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.95 -0.53 1.84e-48 Ulcerative colitis; BRCA cis rs2204008 0.623 rs1607878 chr12:38376000 A/G cg13010199 chr12:38710504 ALG10B 0.42 8.72 0.33 2.48e-17 Bladder cancer; BRCA cis rs938554 0.744 rs7675964 chr4:9941434 C/T cg00071950 chr4:10020882 SLC2A9 -0.36 -7.86 -0.3 1.62e-14 Blood metabolite levels; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg08132940 chr7:1081526 C7orf50 -0.58 -8.81 -0.33 1.21e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2075371 0.932 rs2598290 chr7:133987736 C/G cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.95e-38 Mean platelet volume; BRCA cis rs10504073 0.647 rs9643395 chr8:50014500 A/C cg00325661 chr8:49890786 NA 0.38 11.32 0.41 3.24e-27 Blood metabolite ratios; BRCA cis rs738322 0.967 rs6001038 chr22:38570585 A/G cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg25358565 chr5:93447407 FAM172A -1.09 -15.87 -0.53 4.42e-48 Diabetic retinopathy; BRCA cis rs61931739 0.500 rs7313094 chr12:34457508 T/C cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA cis rs67460515 0.563 rs4679672 chr3:160901020 G/A cg17135325 chr3:160939158 NMD3 0.43 8.35 0.31 4.09e-16 Parkinson's disease; BRCA cis rs7826238 0.502 rs10503377 chr8:8378422 C/T cg15556689 chr8:8085844 FLJ10661 0.39 9.05 0.34 1.68e-18 Systolic blood pressure; BRCA cis rs6920965 0.503 rs2475851 chr6:126174215 T/C cg05901451 chr6:126070800 HEY2 -0.35 -8.55 -0.32 9.08e-17 High light scatter reticulocyte count; BRCA trans rs8002861 0.934 rs9533685 chr13:44468331 A/G cg17145862 chr1:211918768 LPGAT1 0.73 19.51 0.61 7.82e-67 Leprosy; BRCA cis rs10504229 0.683 rs1495865 chr8:58141160 T/G cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg13628971 chr7:2884303 GNA12 0.48 9.42 0.35 8.2e-20 Height; BRCA cis rs6772849 0.930 rs13434160 chr3:128374770 T/C cg16766828 chr3:128327626 NA -0.39 -8.72 -0.33 2.43e-17 Monocyte percentage of white cells;Monocyte count; BRCA trans rs3733585 0.673 rs4447861 chr4:9953940 C/T cg26043149 chr18:55253948 FECH -0.37 -8.25 -0.31 8.96e-16 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs6762477 0.748 rs2073726 chr3:50223593 T/A cg21659725 chr3:3221576 CRBN -0.34 -8.27 -0.31 7.62e-16 Menarche (age at onset); BRCA cis rs61931739 0.500 rs7309931 chr12:34483471 A/C cg06521331 chr12:34319734 NA -0.51 -10.06 -0.37 3.35e-22 Morning vs. evening chronotype; BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.1 18.18 0.58 7.82e-60 Platelet count; BRCA cis rs7666738 0.830 rs9992391 chr4:98916052 G/A cg05340658 chr4:99064831 C4orf37 0.63 15.08 0.51 3.55e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs66887589 0.967 rs1480933 chr4:120433248 C/T cg09307838 chr4:120376055 NA 0.47 9.74 0.36 5.59e-21 Diastolic blood pressure; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg24768116 chr2:27665128 KRTCAP3 -0.35 -8.86 -0.33 7.74e-18 Total body bone mineral density; BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg14863265 chr7:2801509 GNA12 -0.42 -9.4 -0.35 9.55e-20 Height; BRCA cis rs2645694 0.626 rs2703116 chr4:77824289 C/T cg03477792 chr4:77819574 ANKRD56 -0.62 -15.29 -0.52 3.24e-45 Emphysema distribution in smoking; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg04025307 chr7:1156635 C7orf50 0.56 13.9 0.48 1.49e-38 Longevity;Endometriosis; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.0 18.47 0.59 2.24e-61 Platelet count; BRCA cis rs2050392 0.767 rs10763786 chr10:30693567 G/C cg18806716 chr10:30721971 MAP3K8 0.57 13.4 0.47 3.04e-36 Inflammatory bowel disease; BRCA cis rs4722166 0.532 rs6963591 chr7:22757270 G/T cg05472934 chr7:22766657 IL6 -0.43 -10.75 -0.39 7.15e-25 Lung cancer; BRCA trans rs11577318 0.853 rs3795684 chr1:26632781 C/T cg07461501 chr17:79650226 HGS;ARL16 0.38 9.72 0.36 6.51e-21 Granulocyte percentage of myeloid white cells; BRCA cis rs561341 0.714 rs111760509 chr17:30304320 A/G cg23018236 chr17:30244563 NA -0.61 -9.97 -0.37 7.27e-22 Hip circumference adjusted for BMI; BRCA cis rs1371614 0.610 rs2384511 chr2:27152735 G/A cg00617064 chr2:27272375 NA -0.31 -7.98 -0.3 6.97e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.84 -0.33 9.52e-18 Alzheimer's disease (late onset); BRCA cis rs13191362 0.935 rs34009353 chr6:163007668 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.76 12.67 0.45 5.84e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7553864 0.667 rs1886633 chr1:87610356 G/A cg17420885 chr1:87600446 LOC339524 -0.44 -9.03 -0.34 2.06e-18 Smoking behavior; BRCA cis rs2153535 0.601 rs1928183 chr6:8530018 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.74 0.33 2.06e-17 Motion sickness; BRCA cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg18032046 chr6:28092343 ZSCAN16 0.5 8.03 0.3 4.78e-15 Depression; BRCA cis rs6426558 0.502 rs6697665 chr1:227474665 T/C cg10327440 chr1:227177885 CDC42BPA 0.48 9.54 0.35 2.89e-20 Neutrophil percentage of white cells; BRCA trans rs35110281 0.591 rs162390 chr21:44936826 C/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 9.4 0.35 9.64e-20 Mean corpuscular volume; BRCA cis rs7582180 0.629 rs6716636 chr2:100940067 C/G cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA trans rs6582630 0.519 rs8189609 chr12:38281408 A/G cg06521331 chr12:34319734 NA -0.52 -9.54 -0.35 3.06e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs7246967 0.611 rs16999571 chr19:22904764 C/A cg23217946 chr19:22817039 ZNF492 0.51 9.41 0.35 8.44e-20 Bronchopulmonary dysplasia; BRCA cis rs9815354 0.556 rs56201224 chr3:42004427 A/C cg03022575 chr3:42003672 ULK4 0.65 9.47 0.35 5.34e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg26898376 chr11:64110657 CCDC88B 0.36 7.84 0.3 1.95e-14 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs6545883 0.860 rs6545848 chr2:61461183 G/T cg15711740 chr2:61764176 XPO1 0.51 13.06 0.46 1.06e-34 Tuberculosis; BRCA cis rs4919087 1.000 rs4919090 chr10:99088419 C/G cg25902810 chr10:99078978 FRAT1 -0.45 -9.36 -0.35 1.32e-19 Monocyte count; BRCA cis rs61931739 0.517 rs1486882 chr12:34025896 A/G cg06521331 chr12:34319734 NA -0.62 -11.15 -0.4 1.6e-26 Morning vs. evening chronotype; BRCA trans rs9325144 0.510 rs7952795 chr12:38720686 C/T cg23762105 chr12:34175262 ALG10 -0.41 -10.09 -0.37 2.7e-22 Morning vs. evening chronotype; BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg03709012 chr19:19516395 GATAD2A 0.8 18.71 0.6 1.21e-62 Tonsillectomy; BRCA cis rs10044254 0.563 rs4701641 chr5:15697062 C/T cg07238450 chr5:15720153 FBXL7 -0.38 -8.03 -0.3 4.81e-15 Asthma (corticosteroid response); BRCA cis rs7267979 1.000 rs4815424 chr20:25390284 T/C cg08601574 chr20:25228251 PYGB -0.36 -8.68 -0.32 3.18e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.683 rs6998040 chr8:58110155 G/T cg20607798 chr8:58055168 NA -0.45 -7.84 -0.3 1.88e-14 Developmental language disorder (linguistic errors); BRCA cis rs7833790 0.676 rs7834555 chr8:82697625 A/G cg17211192 chr8:82754475 SNX16 -0.5 -10.8 -0.39 4.51e-25 Diastolic blood pressure; BRCA trans rs2204008 0.502 rs2387275 chr12:38142836 G/A cg06521331 chr12:34319734 NA -0.53 -9.5 -0.35 4.12e-20 Bladder cancer; BRCA cis rs9304742 0.854 rs11084211 chr19:53460861 C/T cg24044776 chr19:53454761 ZNF816A -0.39 -8.69 -0.33 2.93e-17 Psoriasis; BRCA cis rs4268898 0.552 rs11125454 chr2:24373669 T/C cg26838691 chr2:24397539 C2orf84 0.39 8.01 0.3 5.52e-15 Asthma; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg04267008 chr7:1944627 MAD1L1 -0.65 -13.79 -0.48 4.62e-38 Bipolar disorder and schizophrenia; BRCA cis rs11229555 0.645 rs11229431 chr11:58181253 A/G cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs4319547 0.695 rs10773152 chr12:122910180 T/C cg05707623 chr12:122985044 ZCCHC8 -0.49 -9.59 -0.35 1.87e-20 Body mass index; BRCA cis rs9486719 1.000 rs2472884 chr6:96863965 C/T cg06623918 chr6:96969491 KIAA0776 0.74 12.99 0.46 2.1e-34 Migraine;Coronary artery disease; BRCA cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.4 -9.51 -0.35 3.81e-20 Tonsillectomy; BRCA cis rs11112613 0.713 rs11112586 chr12:105939816 C/T cg03607813 chr12:105948248 NA 0.53 9.37 0.35 1.2e-19 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.28 -0.41 4.74e-27 IgG glycosylation; BRCA cis rs1707322 1.000 rs7538978 chr1:46505054 C/T cg06784218 chr1:46089804 CCDC17 -0.43 -10.3 -0.38 4.04e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.65 10.69 0.39 1.2e-24 Renal function-related traits (BUN); BRCA cis rs1552244 1.000 rs7637888 chr3:10080722 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.96 19.68 0.61 9.04e-68 Alzheimer's disease; BRCA cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg07148914 chr20:33460835 GGT7 0.4 8.9 0.33 5.87e-18 Height; BRCA cis rs2838344 0.776 rs2298561 chr21:45085234 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.43 -0.38 1.3e-23 Coronary artery disease; BRCA cis rs6088590 1.000 rs6119524 chr20:33373813 C/T cg24642439 chr20:33292090 TP53INP2 0.69 15.8 0.53 1.05e-47 Coronary artery disease; BRCA cis rs10191773 0.584 rs72831633 chr2:112945932 T/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.61 7.81 0.3 2.34e-14 Yeast infection; BRCA cis rs11608355 0.545 rs2302704 chr12:109898797 A/G cg05360138 chr12:110035743 NA 0.69 12.74 0.45 2.67e-33 Neuroticism; BRCA cis rs6460942 0.915 rs62448594 chr7:12442229 C/G cg20607287 chr7:12443886 VWDE -0.58 -8.44 -0.32 2.17e-16 Coronary artery disease; BRCA cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg06453172 chr10:134556979 INPP5A -0.61 -11.66 -0.42 1.32e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs295137 0.752 rs10931892 chr2:201104997 C/T cg23649088 chr2:200775458 C2orf69 -0.39 -8.25 -0.31 8.94e-16 Asthma (bronchodilator response); BRCA cis rs2243480 1.000 rs4149468 chr7:65825690 T/C cg18252515 chr7:66147081 NA -1.06 -15.95 -0.53 1.89e-48 Diabetic kidney disease; BRCA cis rs710865 0.627 rs10799710 chr1:19483209 A/G cg13387374 chr1:19411106 UBR4 0.44 9.75 0.36 4.86e-21 Brain structure; BRCA cis rs950776 0.593 rs6495306 chr15:78865893 C/T cg06917634 chr15:78832804 PSMA4 -0.58 -12.89 -0.45 6.04e-34 Sudden cardiac arrest; BRCA cis rs6831352 0.879 rs34360292 chr4:100051303 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs832540 0.669 rs832538 chr5:56200016 C/T cg12311346 chr5:56204834 C5orf35 -0.54 -11.43 -0.41 1.17e-27 Coronary artery disease; BRCA cis rs3858526 0.959 rs61876223 chr11:5943393 G/A cg25319279 chr11:5960081 NA -0.42 -8.3 -0.31 6.06e-16 DNA methylation (variation); BRCA cis rs4665809 0.590 rs13022190 chr2:26515055 C/T cg25036284 chr2:26402008 FAM59B 0.96 15.93 0.53 2.36e-48 Gut microbiome composition (summer); BRCA cis rs7903847 0.642 rs7092499 chr10:99140313 A/G cg08345082 chr10:99160200 RRP12 -0.29 -8.42 -0.32 2.53e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs1878931 1.000 rs1878931 chr16:3450907 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.81 17.52 0.57 2.09e-56 Body mass index (adult); BRCA cis rs9649465 1.000 rs2299985 chr7:123369044 T/C cg04330084 chr7:123175371 IQUB -0.31 -8.44 -0.32 2.13e-16 Migraine; BRCA cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg11752832 chr7:134001865 SLC35B4 0.49 12.54 0.44 2.19e-32 Mean platelet volume; BRCA cis rs1005277 0.563 rs2800550 chr10:38482929 T/C cg25427524 chr10:38739819 LOC399744 -0.72 -17.9 -0.58 2.24e-58 Extrinsic epigenetic age acceleration; BRCA cis rs9527 0.830 rs3740392 chr10:104636855 T/C cg04362960 chr10:104952993 NT5C2 0.5 10.79 0.39 4.89e-25 Arsenic metabolism; BRCA cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg04450456 chr4:17643702 FAM184B 0.36 10.43 0.38 1.26e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs941873 0.805 rs10762860 chr10:81117794 C/G cg11057378 chr10:81107060 PPIF 0.4 9.55 0.35 2.72e-20 Height; BRCA cis rs12135062 0.851 rs2651926 chr1:3101820 C/T cg21609526 chr1:3105151 PRDM16 -0.38 -9.07 -0.34 1.42e-18 Migraine; BRCA cis rs12618769 0.597 rs11901568 chr2:99128621 C/T cg10123293 chr2:99228465 UNC50 -0.41 -8.1 -0.31 2.72e-15 Bipolar disorder; BRCA cis rs9790314 0.631 rs2061804 chr3:161102474 C/A cg04691961 chr3:161091175 C3orf57 -0.36 -8.28 -0.31 7.09e-16 Morning vs. evening chronotype; BRCA cis rs873946 0.586 rs3793684 chr10:134568645 G/A cg27286337 chr10:134555280 INPP5A 0.78 12.8 0.45 1.48e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg22800045 chr5:56110881 MAP3K1 -0.45 -9.1 -0.34 1.17e-18 Initial pursuit acceleration; BRCA cis rs2762353 0.808 rs1165151 chr6:25821616 T/G cg12310025 chr6:25882481 NA -0.54 -13.03 -0.46 1.3600000000000001e-34 Blood metabolite levels; BRCA cis rs35110281 0.626 rs162389 chr21:44936227 T/C cg21573476 chr21:45109991 RRP1B -0.33 -8.43 -0.32 2.32e-16 Mean corpuscular volume; BRCA cis rs78456975 0.574 rs13412980 chr2:1545231 C/A cg01028140 chr2:1542097 TPO -0.8 -15.97 -0.53 1.43e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.55 12.08 0.43 2.18e-30 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1005277 0.540 rs2224248 chr10:38451886 A/G cg25427524 chr10:38739819 LOC399744 -0.68 -16.54 -0.55 2.07e-51 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.798 rs12468419 chr2:99579680 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -16.05 -0.54 6.08e-49 Chronic sinus infection; BRCA cis rs861020 1.000 rs595918 chr1:209966843 A/G cg09163369 chr1:210001066 C1orf107 0.5 9.45 0.35 6.45e-20 Orofacial clefts; BRCA cis rs9814567 1.000 rs4974493 chr3:134219993 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.85 -0.33 8.34e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs826838 0.967 rs826856 chr12:39115434 G/A cg26384229 chr12:38710491 ALG10B -0.61 -15.83 -0.53 7e-48 Heart rate; BRCA cis rs10870270 1.000 rs10159746 chr10:133742677 C/T cg17892150 chr10:133769511 PPP2R2D -0.73 -15.52 -0.52 2.6e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs514406 0.505 rs395169 chr1:53174071 G/A cg16325326 chr1:53192061 ZYG11B 0.9 25.02 0.7 7.91e-97 Monocyte count; BRCA cis rs9486719 0.947 rs6916232 chr6:96985959 A/T cg06623918 chr6:96969491 KIAA0776 0.78 14.06 0.49 2.59e-39 Migraine;Coronary artery disease; BRCA cis rs10911232 0.507 rs10911194 chr1:182993025 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.79 0.55 1.16e-52 Hypertriglyceridemia; BRCA cis rs6121246 0.609 rs4453755 chr20:30331047 G/A cg13852791 chr20:30311386 BCL2L1 0.84 18.23 0.58 4.23e-60 Mean corpuscular hemoglobin; BRCA cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg11266682 chr4:10021025 SLC2A9 0.48 12.86 0.45 8.33e-34 Bone mineral density; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg03354898 chr7:1950403 MAD1L1 -0.44 -9.41 -0.35 9.04e-20 Bipolar disorder and schizophrenia; BRCA cis rs921968 0.565 rs7603709 chr2:219642601 C/T cg02176678 chr2:219576539 TTLL4 -0.4 -10.92 -0.4 1.41e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg05294307 chr14:35346193 BAZ1A -0.59 -10.24 -0.38 7.11e-23 Psoriasis; BRCA cis rs8016982 0.662 rs8014406 chr14:81657760 A/C cg01989461 chr14:81687754 GTF2A1 0.45 8.24 0.31 9.56e-16 Schizophrenia; BRCA cis rs1059312 1.000 rs7135987 chr12:129280117 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.68 -15.85 -0.53 6.14e-48 Systemic lupus erythematosus; BRCA cis rs2882667 0.690 rs288029 chr5:138217305 A/G cg04439458 chr5:138467593 SIL1 -0.35 -8.41 -0.32 2.69e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2032447 1.000 rs2032447 chr6:26044369 A/G cg03264133 chr6:25882463 NA -0.42 -9.37 -0.35 1.18e-19 Intelligence (multi-trait analysis); BRCA cis rs9858542 0.903 rs9875617 chr3:49634696 G/A cg03060546 chr3:49711283 APEH -0.55 -11.06 -0.4 4.04e-26 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs17270561 0.609 rs7769908 chr6:25760539 G/A cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs2836974 0.563 rs997147 chr21:40695325 A/G cg22974920 chr21:40686053 BRWD1 -0.38 -8.49 -0.32 1.45e-16 Cognitive function; BRCA cis rs250677 0.652 rs250675 chr5:148438565 A/C cg12140854 chr5:148520817 ABLIM3 0.45 9.22 0.34 4.12e-19 Breast cancer; BRCA cis rs8038465 0.638 rs12594175 chr15:73973186 C/T cg15420318 chr15:73925796 NPTN 0.41 9.22 0.34 4.24e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs4665809 1.000 rs6750681 chr2:26329677 C/T cg22920501 chr2:26401640 FAM59B -0.64 -11.15 -0.4 1.66e-26 Gut microbiome composition (summer); BRCA cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg12219531 chr12:120966889 COQ5 0.55 11.48 0.41 7.31e-28 High light scatter reticulocyte count; BRCA cis rs990171 0.506 rs4141632 chr2:102757139 A/G cg22835712 chr2:102737379 NA 0.58 11.07 0.4 3.54e-26 Lymphocyte counts; BRCA cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg18964960 chr10:1102726 WDR37 0.62 8.57 0.32 7.51e-17 Eosinophil percentage of granulocytes; BRCA cis rs11690935 1.000 rs6721680 chr2:172543913 G/T cg13550731 chr2:172543902 DYNC1I2 0.94 31.96 0.78 1.28e-134 Schizophrenia; BRCA trans rs7726839 0.794 rs11739663 chr5:594083 A/G cg25482853 chr8:67687455 SGK3 0.65 12.51 0.44 2.87e-32 Obesity-related traits; BRCA trans rs3198697 0.663 rs12928099 chr16:15150505 C/A cg04146151 chr16:2155961 PKD1 -0.72 -12.43 -0.44 6.57e-32 Triglycerides; BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.76 -13.23 -0.46 1.74e-35 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs35213297 chr4:98984049 T/C cg05340658 chr4:99064831 C4orf37 0.66 16.19 0.54 1.17e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs7103648 0.712 rs10838703 chr11:47422861 C/G cg03711944 chr11:47377212 SPI1 -0.41 -9.89 -0.36 1.46e-21 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs13256369 0.802 rs11249884 chr8:8561552 C/T cg18904891 chr8:8559673 CLDN23 -0.64 -12.56 -0.45 1.66e-32 Obesity-related traits; BRCA cis rs4808199 0.847 rs34647936 chr19:19548239 T/G cg03709012 chr19:19516395 GATAD2A 1.08 21.32 0.64 1.41e-76 Nonalcoholic fatty liver disease; BRCA cis rs2292884 0.505 rs11889660 chr2:238438395 C/T cg08992911 chr2:238395768 MLPH 0.49 8.15 0.31 1.9e-15 Prostate cancer; BRCA cis rs117623576 0.715 rs11008755 chr10:32360053 C/T cg03047570 chr10:32398778 NA 0.5 7.89 0.3 1.36e-14 Anti-saccade response; BRCA cis rs13136331 0.532 rs2627670 chr4:88564988 A/G cg22416721 chr4:88570574 DMP1 -0.6 -14.45 -0.5 3.53e-41 Sitting height ratio; BRCA cis rs6598955 0.671 rs12141563 chr1:26589636 A/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA trans rs61931739 0.517 rs11052977 chr12:34035030 A/C cg26384229 chr12:38710491 ALG10B 0.68 14.24 0.49 3.75e-40 Morning vs. evening chronotype; BRCA cis rs3796352 1.000 rs35174175 chr3:53041509 T/C cg07884673 chr3:53033167 SFMBT1 0.88 10.31 0.38 3.62e-23 Immune reponse to smallpox (secreted IL-2); BRCA cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg22467129 chr15:76604101 ETFA -0.42 -9.43 -0.35 7.52e-20 Blood metabolite levels; BRCA cis rs11955398 0.563 rs10471493 chr5:60035222 C/T cg02684056 chr5:59996105 DEPDC1B -0.38 -9.0 -0.34 2.64e-18 Intelligence (multi-trait analysis); BRCA trans rs57221529 0.655 rs11948381 chr5:568413 A/T cg25482853 chr8:67687455 SGK3 0.78 13.72 0.48 1.03e-37 Lung disease severity in cystic fibrosis; BRCA cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg06552810 chr11:31128660 NA -0.38 -8.77 -0.33 1.58e-17 Red blood cell count; BRCA cis rs2836974 0.568 rs414850 chr21:40543337 A/C cg17971929 chr21:40555470 PSMG1 0.62 14.38 0.49 8.35e-41 Cognitive function; BRCA cis rs4478858 0.735 rs10798845 chr1:31822636 A/G cg00250761 chr1:31883323 NA 0.32 8.4 0.32 2.91e-16 Alcohol dependence; BRCA cis rs425277 0.606 rs262663 chr1:2084598 T/C cg04315214 chr1:2043799 PRKCZ -0.47 -13.16 -0.46 3.5e-35 Height; BRCA cis rs919433 0.963 rs10166569 chr2:198183439 G/A cg10820045 chr2:198174542 NA -0.39 -8.0 -0.3 6.04e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs6450176 0.909 rs12659966 chr5:53292892 C/G ch.5.1024479R chr5:53302184 ARL15 0.59 14.11 0.49 1.52e-39 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs1008375 0.931 rs3796814 chr4:17602033 G/C cg16339924 chr4:17578868 LAP3 0.62 15.37 0.52 1.3e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs933688 1.000 rs12656350 chr5:90751343 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.75 15.62 0.53 7.86e-47 Smoking behavior; BRCA cis rs10489202 0.608 rs7553238 chr1:168076768 G/A cg24449463 chr1:168025552 DCAF6 -0.46 -14.51 -0.5 1.88e-41 Schizophrenia; BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg20203395 chr5:56204925 C5orf35 -0.52 -10.5 -0.38 6.58e-24 Initial pursuit acceleration; BRCA cis rs9837602 1.000 rs9833980 chr3:99767096 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.29e-26 Breast cancer; BRCA cis rs5758511 0.680 rs739146 chr22:42660414 A/G cg00645731 chr22:42541494 CYP2D7P1 0.49 9.6 0.35 1.79e-20 Birth weight; BRCA cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg00071950 chr4:10020882 SLC2A9 -0.48 -11.0 -0.4 6.6900000000000006e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs8177253 0.901 rs9843728 chr3:133501407 C/T cg16414030 chr3:133502952 NA -0.45 -10.61 -0.39 2.42e-24 Iron status biomarkers; BRCA trans rs11039798 0.502 rs961863 chr11:48417021 T/C cg15704280 chr7:45808275 SEPT13 -0.57 -9.65 -0.36 1.14e-20 Axial length; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg21747090 chr2:27597821 SNX17 -0.42 -9.13 -0.34 9.17e-19 Total body bone mineral density; BRCA cis rs1215050 0.740 rs6855827 chr4:99065706 G/A cg05340658 chr4:99064831 C4orf37 0.5 11.58 0.42 2.71e-28 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs243505 0.861 rs243531 chr7:148412513 A/G cg09806900 chr7:148480153 CUL1 -0.4 -8.23 -0.31 1.03e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11025559 0.796 rs10833317 chr11:20412277 A/T cg19653624 chr11:20408972 PRMT3 -0.44 -10.02 -0.37 4.65e-22 Pursuit maintenance gain; BRCA cis rs9399135 0.967 rs4896122 chr6:135295081 T/C cg24558204 chr6:135376177 HBS1L 0.46 12.59 0.45 1.23e-32 Red blood cell count; BRCA cis rs495337 0.736 rs537672 chr20:48473546 T/A cg17835207 chr20:48524531 SPATA2 -0.5 -11.06 -0.4 3.87e-26 Psoriasis; BRCA cis rs651907 0.557 rs11925001 chr3:101373966 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.85 0.51 4.29e-43 Colorectal cancer; BRCA cis rs7666738 0.830 rs3896704 chr4:99034252 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 0.726 rs1463393 chr3:46994987 G/A cg16586182 chr3:47516702 SCAP 0.52 11.43 0.41 1.16e-27 Colorectal cancer; BRCA cis rs4423214 0.879 rs1792283 chr11:71135136 T/C cg05163923 chr11:71159392 DHCR7 -0.51 -10.24 -0.38 6.61e-23 Vitamin D levels; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg18538332 chr22:24372958 LOC391322 -0.56 -14.09 -0.49 1.93e-39 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1113500 0.730 rs1781080 chr1:108593415 G/A cg06207961 chr1:108661230 NA -0.33 -7.82 -0.3 2.17e-14 Growth-regulated protein alpha levels; BRCA trans rs61931739 0.517 rs11052964 chr12:34010996 G/C cg26384229 chr12:38710491 ALG10B 0.68 14.03 0.49 3.7e-39 Morning vs. evening chronotype; BRCA cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.55 -14.19 -0.49 6.49e-40 Electrocardiographic conduction measures; BRCA cis rs769267 0.965 rs2315024 chr19:19423817 T/A cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.45 0.35 6.36e-20 Tonsillectomy; BRCA cis rs1552244 0.882 rs6443279 chr3:10053599 C/A cg13047869 chr3:10149882 C3orf24 0.57 11.77 0.42 4.49e-29 Alzheimer's disease; BRCA cis rs7904368 0.754 rs7076779 chr10:16852667 C/T cg14835575 chr10:16859367 RSU1 0.61 13.05 0.46 1.09e-34 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs6815814 0.950 rs5743563 chr4:38806019 A/G cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs2011503 0.941 rs72999063 chr19:19380596 G/T cg11584989 chr19:19387371 SF4 0.6 13.8 0.48 3.99e-38 Bipolar disorder; BRCA cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg10523679 chr1:76189770 ACADM 0.69 12.23 0.44 4.79e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.73 0.33 2.27e-17 Rheumatoid arthritis; BRCA cis rs3845702 0.736 rs115569960 chr2:180848214 C/T cg01881094 chr2:180872142 CWC22 1.01 16.94 0.56 1.88e-53 Schizophrenia; BRCA cis rs798554 1.000 rs798560 chr7:2758309 A/G cg12444411 chr7:2802554 GNA12 -0.35 -8.45 -0.32 1.98e-16 Height; BRCA cis rs9815354 0.812 rs113772069 chr3:41933389 T/C cg03022575 chr3:42003672 ULK4 0.69 9.5 0.35 4.17e-20 Pulse pressure;Diastolic blood pressure; BRCA trans rs2018683 0.523 rs1499227 chr7:29025615 C/T cg19402173 chr7:128379420 CALU -0.37 -8.15 -0.31 1.86e-15 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs875971 0.660 rs10272357 chr7:66063074 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.58 -0.32 7.44e-17 Aortic root size; BRCA trans rs7647973 0.710 rs2029591 chr3:49646981 C/T cg21659725 chr3:3221576 CRBN 0.46 8.34 0.31 4.55e-16 Menarche (age at onset); BRCA cis rs708547 0.874 rs1315006 chr4:57858193 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 10.65 0.39 1.72e-24 Response to bleomycin (chromatid breaks); BRCA cis rs2836974 0.568 rs11910906 chr21:40685662 T/C cg11890956 chr21:40555474 PSMG1 -0.81 -19.11 -0.6 9.6e-65 Cognitive function; BRCA cis rs651907 0.557 rs13077925 chr3:101488181 T/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.31 0.49 1.77e-40 Colorectal cancer; BRCA cis rs3892630 0.612 rs10413282 chr19:33182751 A/G cg22980127 chr19:33182716 NUDT19 0.97 23.93 0.69 7.47e-91 Red blood cell traits; BRCA cis rs9790314 1.000 rs1382426 chr3:161045933 G/A cg03342759 chr3:160939853 NMD3 -0.65 -13.83 -0.48 3.01e-38 Morning vs. evening chronotype; BRCA cis rs6942756 0.747 rs598412 chr7:129127736 C/T cg02491457 chr7:128862824 NA 0.56 11.75 0.42 5.27e-29 White matter hyperintensity burden; BRCA cis rs9467773 1.000 rs3736782 chr6:26505403 C/A cg11502198 chr6:26597334 ABT1 0.47 9.48 0.35 4.75e-20 Intelligence (multi-trait analysis); BRCA trans rs7395662 0.500 rs1605360 chr11:48685714 G/A cg00717180 chr2:96193071 NA -0.4 -11.17 -0.4 1.43e-26 HDL cholesterol; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA trans rs61931739 0.500 rs7488438 chr12:34531359 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.73 0.36 5.91e-21 Morning vs. evening chronotype; BRCA cis rs11122272 0.735 rs2749709 chr1:231530476 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.52 -12.39 -0.44 9.69e-32 Hemoglobin concentration; BRCA cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg02544614 chr20:61657117 NA 0.28 8.15 0.31 1.93e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs77972916 0.536 rs7562101 chr2:43592756 T/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -10.96 -0.4 9.85e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg05793240 chr7:2802953 GNA12 -0.31 -7.85 -0.3 1.75e-14 Height; BRCA cis rs1865760 1.000 rs6938233 chr6:25914077 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.45 0.38 1.02e-23 Height; BRCA cis rs10870270 1.000 rs4880263 chr10:133787629 C/T cg26149184 chr10:133730230 NA 0.41 8.15 0.31 1.85e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg18876405 chr7:65276391 NA -0.61 -15.33 -0.52 2.17e-45 Aortic root size; BRCA cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg25767906 chr1:53392781 SCP2 -0.38 -8.57 -0.32 7.5e-17 Monocyte count; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 19.62 0.61 1.99e-67 Platelet count; BRCA cis rs873946 0.517 rs2803990 chr10:134560340 A/G cg18305652 chr10:134549665 INPP5A 0.42 11.88 0.43 1.54e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs35306767 0.903 rs17159950 chr10:875287 T/G cg20503657 chr10:835505 NA 1.06 18.28 0.59 2.34e-60 Eosinophil percentage of granulocytes; BRCA cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg25427524 chr10:38739819 LOC399744 0.67 16.23 0.54 7.29e-50 Extrinsic epigenetic age acceleration; BRCA cis rs4642101 0.662 rs9874893 chr3:12833079 C/G cg05775895 chr3:12838266 CAND2 0.36 7.9 0.3 1.2e-14 QRS complex (12-leadsum); BRCA cis rs12586317 0.586 rs74243590 chr14:35513246 G/A cg05294307 chr14:35346193 BAZ1A -0.62 -10.45 -0.38 1e-23 Psoriasis; BRCA trans rs9325144 0.560 rs6582561 chr12:38666821 G/A cg23762105 chr12:34175262 ALG10 0.34 7.96 0.3 7.76e-15 Morning vs. evening chronotype; BRCA cis rs921968 0.509 rs556468 chr2:219355794 G/A cg02176678 chr2:219576539 TTLL4 0.45 11.62 0.42 1.97e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.2 0.66 2.32e-81 Platelet count; BRCA cis rs56804039 1.000 rs7017341 chr8:8381664 C/A cg06636001 chr8:8085503 FLJ10661 -0.57 -9.31 -0.35 2e-19 Cervical cancer; BRCA cis rs189798 0.738 rs330908 chr8:8995166 A/G cg06636001 chr8:8085503 FLJ10661 0.41 8.09 0.3 2.91e-15 Myopia (pathological); BRCA cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg11752832 chr7:134001865 SLC35B4 0.56 14.43 0.5 4.5e-41 Mean platelet volume; BRCA cis rs6964587 1.000 rs2282968 chr7:91580287 A/C cg01689657 chr7:91764605 CYP51A1 -0.23 -8.29 -0.31 6.78e-16 Breast cancer; BRCA cis rs870825 0.616 rs10025167 chr4:185649551 A/C cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs2304069 0.644 rs216131 chr5:149431223 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.61 11.76 0.42 5.04e-29 HIV-1 control; BRCA cis rs72615157 0.634 rs74742883 chr7:99785765 T/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.56 8.75 0.33 1.94e-17 Lung function (FEV1/FVC); BRCA cis rs1865760 0.613 rs9379801 chr6:25901711 T/C cg03264133 chr6:25882463 NA -0.42 -9.74 -0.36 5.23e-21 Height; BRCA cis rs3768617 0.745 rs4546885 chr1:183025555 C/G ch.1.3577855R chr1:183094577 LAMC1 0.44 9.51 0.35 3.73e-20 Fuchs's corneal dystrophy; BRCA cis rs6866344 0.697 rs6873150 chr5:178125704 G/A cg10224037 chr5:178157518 ZNF354A 0.72 15.34 0.52 2e-45 Neutrophil percentage of white cells; BRCA cis rs2288073 0.896 rs13404513 chr2:24410780 G/A cg06627628 chr2:24431161 ITSN2 -0.63 -12.02 -0.43 3.88e-30 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9486719 0.895 rs4486019 chr6:96883814 T/C cg06623918 chr6:96969491 KIAA0776 -0.72 -12.96 -0.46 2.7200000000000002e-34 Migraine;Coronary artery disease; BRCA cis rs523522 0.962 rs3213565 chr12:120992401 C/T cg27279351 chr12:120934652 DYNLL1 0.56 13.23 0.46 1.7000000000000001e-35 High light scatter reticulocyte count; BRCA cis rs6066835 1.000 rs73136396 chr20:47337174 T/A cg18078177 chr20:47281410 PREX1 0.72 7.84 0.3 1.96e-14 Multiple myeloma; BRCA cis rs6733011 0.578 rs4851170 chr2:99504323 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.36 8.32 0.31 5.3e-16 Bipolar disorder; BRCA cis rs2762353 0.935 rs3757131 chr6:25783909 C/T cg12310025 chr6:25882481 NA 0.52 12.29 0.44 2.7e-31 Blood metabolite levels; BRCA cis rs6456156 0.565 rs12529959 chr6:167469292 T/C cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs4363385 0.818 rs4845522 chr1:153011099 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA trans rs6089829 0.855 rs4809459 chr20:61661345 C/T cg23505145 chr19:12996616 KLF1 0.56 12.79 0.45 1.66e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.720 rs1415968 chr1:152970219 C/G cg21543102 chr1:152974771 SPRR3 -0.28 -8.04 -0.3 4.2e-15 Inflammatory skin disease; BRCA trans rs931812 0.757 rs35569317 chr8:101907971 T/C cg20993868 chr7:22813445 NA 0.45 13.33 0.47 6.03e-36 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs4665809 0.793 rs6546715 chr2:26261520 G/A cg25036284 chr2:26402008 FAM59B -0.63 -10.96 -0.4 1.02e-25 Gut microbiome composition (summer); BRCA cis rs514406 0.505 rs269292 chr1:53187911 T/C cg08859206 chr1:53392774 SCP2 -0.43 -8.62 -0.32 5.43e-17 Monocyte count; BRCA cis rs7666738 0.753 rs1527520 chr4:98929164 A/G cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9420 0.925 rs488769 chr11:57450720 A/C cg19752551 chr11:57585705 CTNND1 -0.42 -10.52 -0.38 5.42e-24 Schizophrenia; BRCA cis rs9311474 0.607 rs34005367 chr3:52558904 A/T cg10802521 chr3:52805072 NEK4 -0.3 -7.82 -0.3 2.16e-14 Electroencephalogram traits; BRCA cis rs7829975 0.840 rs572366 chr8:8578794 A/T cg06636001 chr8:8085503 FLJ10661 0.59 13.42 0.47 2.26e-36 Mood instability; BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg04166393 chr7:2884313 GNA12 0.49 9.38 0.35 1.1e-19 Height; BRCA cis rs7044106 0.791 rs7036766 chr9:123479621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 14.87 0.51 3.63e-43 Hip circumference adjusted for BMI; BRCA cis rs3741404 0.791 rs7112960 chr11:63907079 A/G cg19465662 chr11:63993652 NUDT22;TRPT1 0.85 19.65 0.61 1.42e-67 Platelet count; BRCA cis rs7539409 0.833 rs2057083 chr1:84269942 T/G cg10977910 chr1:84465055 TTLL7 0.67 9.64 0.36 1.26e-20 Alzheimer's disease; BRCA cis rs1949733 1.000 rs2631745 chr4:8490530 T/C cg13073564 chr4:8508604 NA 0.44 11.88 0.43 1.55e-29 Response to antineoplastic agents; BRCA cis rs7309 0.935 rs1921309 chr2:162048975 T/A cg16506815 chr2:162101123 NA 0.72 18.05 0.58 3.57e-59 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs9389248 0.737 rs56358308 chr6:135306980 A/T cg24558204 chr6:135376177 HBS1L 0.59 15.94 0.53 2.02e-48 High light scatter reticulocyte percentage of red cells; BRCA cis rs4862750 0.957 rs2375916 chr4:187903923 A/G cg10295955 chr4:187884368 NA -0.88 -25.8 -0.71 4.27e-101 Lobe attachment (rater-scored or self-reported); BRCA cis rs365132 0.934 rs183686 chr5:176494102 A/G cg16309518 chr5:176445507 NA -0.52 -12.97 -0.46 2.7e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs3739998 0.692 rs11007864 chr10:30313117 T/C cg00730780 chr10:30316187 KIAA1462 0.55 11.4 0.41 1.57e-27 Coronary heart disease; BRCA trans rs6582630 0.519 rs8189618 chr12:38276281 A/C cg06521331 chr12:34319734 NA -0.49 -9.15 -0.34 7.35e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.54 -0.32 9.46e-17 Aortic root size; BRCA cis rs2274471 0.645 rs73639261 chr9:5084215 G/A cg03390472 chr9:5043263 JAK2 -0.47 -7.85 -0.3 1.76e-14 Crohn's disease; BRCA cis rs763014 0.932 rs2269560 chr16:682442 A/C cg09256448 chr16:638327 NA 0.3 7.94 0.3 8.99e-15 Height; BRCA cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.8 18.55 0.59 8.36e-62 Birth weight; BRCA cis rs6088590 0.561 rs11167239 chr20:33140472 G/A cg24642439 chr20:33292090 TP53INP2 0.57 12.4 0.44 8.54e-32 Coronary artery disease; BRCA cis rs12477438 0.501 rs6727749 chr2:99793590 C/T cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs2658782 0.547 rs3020065 chr11:93059899 A/G cg15737290 chr11:93063684 CCDC67 0.58 13.57 0.47 5.01e-37 Pulmonary function decline; BRCA cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.56 9.29 0.34 2.45e-19 Renal function-related traits (BUN); BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs757110 0.866 rs5213 chr11:17408404 C/T cg04705435 chr11:17411270 KCNJ11 0.46 9.62 0.36 1.45e-20 Type 2 diabetes; BRCA cis rs2629751 0.512 rs2723868 chr12:104422317 C/T cg14987745 chr12:104360022 TDG -0.5 -9.42 -0.35 8.1e-20 Hepatitis C induced liver fibrosis; BRCA cis rs6951245 1.000 rs80094748 chr7:1103958 G/A cg24642844 chr7:1081250 C7orf50 -0.88 -15.99 -0.53 1.13e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11585357 0.947 rs2977303 chr1:17611548 A/T cg19159961 chr1:17633534 PADI4 0.46 8.48 0.32 1.57e-16 Hair shape; BRCA cis rs1862618 0.641 rs252893 chr5:56224714 T/C cg24549020 chr5:56110836 MAP3K1 0.41 8.58 0.32 7.34e-17 Initial pursuit acceleration; BRCA cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg23791538 chr6:167370224 RNASET2 -0.37 -9.22 -0.34 4.17e-19 Crohn's disease; BRCA cis rs10191773 0.589 rs72831638 chr2:112949212 C/G cg07905836 chr2:113190072 RGPD8;RGPD5 0.61 7.81 0.3 2.34e-14 Yeast infection; BRCA cis rs8032158 1.000 rs8029247 chr15:56273446 C/T cg02198044 chr15:56286336 NEDD4 0.36 8.66 0.32 3.9e-17 Keloid; BRCA cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.853 rs2113078 chr5:56087190 C/T cg24549020 chr5:56110836 MAP3K1 0.67 13.19 0.46 2.7e-35 Initial pursuit acceleration; BRCA cis rs35306767 0.953 rs34405399 chr10:981015 G/A cg25019033 chr10:957182 NA -0.42 -8.68 -0.32 3.28e-17 Eosinophil percentage of granulocytes; BRCA cis rs896854 0.967 rs896853 chr8:95960855 G/C cg16049864 chr8:95962084 TP53INP1 -0.49 -12.25 -0.44 3.9e-31 Type 2 diabetes; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11141652 chr22:24348549 GSTTP1 -0.43 -8.8 -0.33 1.26e-17 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg01802117 chr1:53393560 SCP2 0.41 8.59 0.32 6.73e-17 Monocyte count; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.16e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2425143 0.908 rs75331436 chr20:34391052 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.99 -0.34 2.73e-18 Blood protein levels; BRCA cis rs28595532 1.000 rs11098451 chr4:119717673 C/T cg14228332 chr4:119757509 SEC24D 0.62 7.99 0.3 6.18e-15 Cannabis dependence symptom count; BRCA cis rs11098499 0.863 rs1383532 chr4:120434404 A/T cg09307838 chr4:120376055 NA -0.69 -13.9 -0.48 1.38e-38 Corneal astigmatism; BRCA cis rs17741873 0.779 rs10509346 chr10:75596014 A/G cg07699608 chr10:75541558 CHCHD1 -0.51 -8.26 -0.31 8.58e-16 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs9788721 0.592 rs28564957 chr15:78906107 C/A cg06917634 chr15:78832804 PSMA4 -0.55 -11.73 -0.42 6.6e-29 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs6582630 0.555 rs1969362 chr12:38514843 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.72 0.57 1.98e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs17253792 0.822 rs76472022 chr14:56053660 C/T cg01858014 chr14:56050164 KTN1 -0.73 -9.37 -0.35 1.19e-19 Putamen volume; BRCA cis rs11718455 0.920 rs4682927 chr3:44033299 C/A cg08738300 chr3:44038990 NA 0.44 8.52 0.32 1.16e-16 Coronary artery disease; BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg18230493 chr5:56204884 C5orf35 -0.73 -14.9 -0.51 2.68e-43 Initial pursuit acceleration; BRCA cis rs9399137 0.507 rs4896128 chr6:135349756 A/G cg22676075 chr6:135203613 NA -0.45 -8.95 -0.33 3.77e-18 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs6582630 0.519 rs4436613 chr12:38293653 T/C cg13010199 chr12:38710504 ALG10B 0.5 10.53 0.38 4.99e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs2288912 0.838 rs2239375 chr19:45459851 T/C cg13119609 chr19:45449297 APOC2 0.47 13.12 0.46 5.38e-35 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1008375 0.902 rs6844984 chr4:17651304 C/G cg02297831 chr4:17616191 MED28 0.37 8.71 0.33 2.68e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg23229984 chr5:148520753 ABLIM3 0.36 8.84 0.33 9.05e-18 Breast cancer; BRCA cis rs4563143 0.647 rs34218744 chr19:29256821 A/T cg12667521 chr19:29218732 NA 0.47 8.68 0.32 3.4e-17 Methadone dose in opioid dependence; BRCA cis rs12681288 0.523 rs6983944 chr8:955147 A/G cg04851639 chr8:1020857 NA -0.31 -8.91 -0.33 5.39e-18 Schizophrenia; BRCA cis rs9811920 0.516 rs793485 chr3:99492383 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.86 -0.36 1.97e-21 Axial length; BRCA cis rs7666738 0.830 rs13138438 chr4:99050545 C/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs9854299 chr3:134206728 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -8.98 -0.33 3.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2710642 0.678 rs11125946 chr2:63298150 C/T cg17519650 chr2:63277830 OTX1 -0.44 -9.41 -0.35 8.63e-20 LDL cholesterol levels;LDL cholesterol; BRCA cis rs7264396 0.790 rs6060582 chr20:34313297 A/G cg23207816 chr20:34252616 CPNE1;RBM12 -0.39 -8.35 -0.31 4.22e-16 Total cholesterol levels; BRCA cis rs17270561 1.000 rs12211184 chr6:25823774 G/A cg17691542 chr6:26056736 HIST1H1C 0.76 13.47 0.47 1.44e-36 Iron status biomarkers; BRCA cis rs1707322 0.752 rs11211171 chr1:46168642 A/G cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6120849 0.663 rs6088662 chr20:33547633 A/C cg24642439 chr20:33292090 TP53INP2 0.55 9.67 0.36 9.67e-21 Protein C levels; BRCA cis rs250677 0.522 rs998304 chr5:148382365 C/A cg18129178 chr5:148520854 ABLIM3 -0.54 -10.51 -0.38 6.29e-24 Breast cancer; BRCA cis rs4819052 0.765 rs2838854 chr21:46680364 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.1 0.49 1.73e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg19723775 chr5:179050963 HNRNPH1 -0.38 -9.39 -0.35 1.05e-19 Lung cancer; BRCA cis rs72781680 0.716 rs2712068 chr2:23984000 A/G cg08917208 chr2:24149416 ATAD2B 0.64 10.15 0.37 1.57e-22 Lymphocyte counts; BRCA cis rs68170813 0.527 rs78133594 chr7:107025260 T/C cg02696742 chr7:106810147 HBP1 -0.49 -8.53 -0.32 1.05e-16 Coronary artery disease; BRCA cis rs875971 0.862 rs17747530 chr7:65994729 G/C cg11764359 chr7:65958608 NA 0.76 16.82 0.55 7.85e-53 Aortic root size; BRCA cis rs2267137 0.903 rs2283850 chr22:29772391 G/C cg07256473 chr22:29710276 RASL10A 0.36 8.91 0.33 5.47e-18 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg07414643 chr4:187882934 NA 0.28 9.48 0.35 4.74e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.738 rs67545510 chr1:46806242 G/T cg10495392 chr1:46806563 NSUN4 0.45 8.22 0.31 1.12e-15 Menopause (age at onset); BRCA cis rs57221529 0.766 rs4081847 chr5:574072 C/T cg20362242 chr5:692897 TPPP 0.53 8.51 0.32 1.28e-16 Lung disease severity in cystic fibrosis; BRCA cis rs2171564 0.967 rs9874987 chr3:112435997 G/C cg06685282 chr3:112453648 NA -0.36 -7.81 -0.3 2.42e-14 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs34779708 0.643 rs4275563 chr10:35545286 G/A cg03585969 chr10:35415529 CREM 0.45 9.13 0.34 8.8e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6570726 0.791 rs401331 chr6:145831408 A/G cg23711669 chr6:146136114 FBXO30 0.77 17.97 0.58 9.78e-59 Lobe attachment (rater-scored or self-reported); BRCA cis rs1580019 0.961 rs766657 chr7:32499510 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.4 8.72 0.33 2.48e-17 Cognitive ability; BRCA cis rs34779708 0.931 rs67261877 chr10:35386340 T/A cg03585969 chr10:35415529 CREM 0.56 11.54 0.42 3.91e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9487051 0.803 rs410449 chr6:109539853 C/T cg01475377 chr6:109611718 NA -0.42 -10.01 -0.37 5.25e-22 Reticulocyte fraction of red cells; BRCA cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg17971929 chr21:40555470 PSMG1 -0.61 -13.89 -0.48 1.67e-38 Cognitive function; BRCA cis rs6088580 0.634 rs6059829 chr20:33017074 G/A cg06115741 chr20:33292138 TP53INP2 0.39 8.68 0.32 3.31e-17 Glomerular filtration rate (creatinine); BRCA cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg18196295 chr10:418757 DIP2C 0.49 11.74 0.42 5.63e-29 Psychosis in Alzheimer's disease; BRCA cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg06242242 chr7:766104 PRKAR1B;HEATR2 -0.57 -8.45 -0.32 2.03e-16 Cerebrospinal P-tau181p levels; BRCA trans rs2840044 1.000 rs17637907 chr17:33891386 A/G cg19694781 chr19:47549865 TMEM160 0.46 11.02 0.4 5.72e-26 Response to radiotherapy in cancer (late toxicity); BRCA cis rs72781680 0.581 rs116520786 chr2:24272645 C/T cg06627628 chr2:24431161 ITSN2 -0.55 -8.93 -0.33 4.59e-18 Lymphocyte counts; BRCA cis rs877529 1.000 rs877529 chr22:39542292 G/A cg12193277 chr22:39547181 CBX7 0.46 12.74 0.45 2.6e-33 Multiple myeloma; BRCA cis rs6951245 1.000 rs113575110 chr7:1084394 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.16e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg23205692 chr1:25664452 TMEM50A 0.39 9.58 0.35 2.05e-20 Erythrocyte sedimentation rate; BRCA cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs16866061 0.962 rs16825685 chr2:225434256 C/G cg12698349 chr2:225449008 CUL3 0.78 21.46 0.65 2.47e-77 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs910316 0.967 rs175505 chr14:75529619 C/T cg08847533 chr14:75593920 NEK9 -0.87 -22.08 -0.66 1e-80 Height; BRCA cis rs708547 1.000 rs2412770 chr4:57794660 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 10.84 0.39 3.09e-25 Response to bleomycin (chromatid breaks); BRCA cis rs7560272 0.501 rs17350188 chr2:73964842 C/G cg20560298 chr2:73613845 ALMS1 -0.35 -8.88 -0.33 6.73e-18 Schizophrenia; BRCA cis rs10751667 0.666 rs6597957 chr11:982294 T/A cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.06e-48 Alzheimer's disease (late onset); BRCA cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg10523679 chr1:76189770 ACADM 0.76 15.91 0.53 2.96e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11971779 0.680 rs11764236 chr7:139118514 C/T cg07862535 chr7:139043722 LUC7L2 0.39 10.38 0.38 2.02e-23 Diisocyanate-induced asthma; BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg18765753 chr7:1198926 ZFAND2A -0.35 -7.83 -0.3 2.06e-14 Longevity;Endometriosis; BRCA trans rs10506458 1.000 rs11174759 chr12:63444363 A/T cg22491629 chr6:157744540 C6orf35 -0.65 -11.68 -0.42 1.07e-28 Hemostatic factors and hematological phenotypes; BRCA cis rs2836974 0.897 rs13339986 chr21:40605982 T/C cg11890956 chr21:40555474 PSMG1 1.0 24.69 0.7 5.17e-95 Cognitive function; BRCA trans rs8073060 0.821 rs11080355 chr17:33872694 T/A cg19694781 chr19:47549865 TMEM160 0.56 11.84 0.42 2.33e-29 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs274567 0.501 rs272856 chr5:131687081 G/C cg07395648 chr5:131743802 NA -0.37 -8.07 -0.3 3.45e-15 Blood metabolite levels; BRCA cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg04166393 chr7:2884313 GNA12 0.63 13.77 0.48 5.94e-38 Height; BRCA cis rs6831352 0.879 rs2602888 chr4:100041706 C/T cg13256891 chr4:100009986 ADH5 0.52 9.56 0.35 2.46e-20 Alcohol dependence; BRCA cis rs881375 0.715 rs7858209 chr9:123645760 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.73 0.33 2.27e-17 Rheumatoid arthritis; BRCA cis rs3806843 0.808 rs6893708 chr5:140125922 T/C cg16179182 chr5:140090404 VTRNA1-1 0.41 9.32 0.35 1.93e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs2836950 0.502 rs2150411 chr21:40574552 G/T cg11890956 chr21:40555474 PSMG1 -0.65 -14.96 -0.51 1.4e-43 Menarche (age at onset); BRCA cis rs7631605 0.935 rs4647224 chr3:37043230 G/A cg15934958 chr3:37212084 LRRFIP2 0.41 9.53 0.35 3.19e-20 Cerebrospinal P-tau181p levels; BRCA trans rs561341 1.000 rs555629 chr17:30294136 T/C cg27661571 chr11:113659931 NA -0.7 -10.88 -0.4 2e-25 Hip circumference adjusted for BMI; BRCA trans rs2727020 0.521 rs10839296 chr11:49537617 T/C cg11707556 chr5:10655725 ANKRD33B 0.44 9.74 0.36 5.31e-21 Coronary artery disease; BRCA cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 9.39 0.35 1.02e-19 Personality dimensions; BRCA cis rs16976116 0.901 rs62020097 chr15:55491007 A/T cg11288833 chr15:55489084 RSL24D1 0.47 10.61 0.39 2.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs5760092 0.572 rs738806 chr22:24234172 A/G cg20007245 chr22:24372913 LOC391322 -0.45 -8.54 -0.32 1.02e-16 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs68170813 0.523 rs12532447 chr7:106940476 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.65 -0.32 4.3e-17 Coronary artery disease; BRCA cis rs12497850 0.931 rs9311432 chr3:48850443 T/A cg06212747 chr3:49208901 KLHDC8B 0.47 9.61 0.36 1.65e-20 Parkinson's disease; BRCA cis rs775227 0.574 rs13067967 chr3:113265215 C/G cg18753928 chr3:113234510 CCDC52 -0.57 -9.66 -0.36 1.1e-20 Dental caries; BRCA cis rs2479724 0.870 rs3747753 chr6:41753380 G/T cg17623882 chr6:41773611 USP49 0.38 10.45 0.38 1.07e-23 Menarche (age at onset); BRCA cis rs1538970 0.962 rs7544178 chr1:45819069 C/T cg05343316 chr1:45956843 TESK2 0.58 11.69 0.42 9.38e-29 Platelet count; BRCA cis rs4363385 0.693 rs662506 chr1:153048386 A/C cg25856811 chr1:152973957 SPRR3 0.3 7.85 0.3 1.78e-14 Inflammatory skin disease; BRCA cis rs1801251 1.000 rs283479 chr2:233648754 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.04 0.4 4.74e-26 Coronary artery disease; BRCA cis rs9463078 0.753 rs10948186 chr6:44903248 C/T cg25276700 chr6:44698697 NA -0.37 -8.65 -0.32 4.27e-17 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs71636778 0.509 rs71636795 chr1:27241025 A/G cg12203394 chr1:27248618 NUDC 0.6 9.46 0.35 5.7e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs2304069 0.954 rs2276983 chr5:149424966 C/T cg10852222 chr5:149380144 HMGXB3;TIGD6 0.53 8.67 0.32 3.63e-17 HIV-1 control; BRCA cis rs6815814 0.847 rs11725309 chr4:38783848 T/C cg06935464 chr4:38784597 TLR10 0.5 8.19 0.31 1.42e-15 Breast cancer; BRCA cis rs9287719 0.967 rs7600728 chr2:10739999 A/G cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs72772090 0.539 rs3333 chr5:96115111 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -12.17 -0.43 9e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs701145 0.556 rs355779 chr3:153977253 T/C cg12800244 chr3:153838788 SGEF 0.43 8.61 0.32 5.67e-17 Coronary artery disease; BRCA cis rs17641971 0.662 rs10435575 chr8:49996107 C/T cg00325661 chr8:49890786 NA 0.39 10.8 0.39 4.5e-25 Blood metabolite levels; BRCA cis rs12711979 0.509 rs10181286 chr2:3824567 G/A cg17052675 chr2:3827356 NA -0.7 -23.65 -0.68 2.6e-89 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4268898 0.735 rs34125395 chr2:24558242 C/T cg06627628 chr2:24431161 ITSN2 0.42 8.84 0.33 9.53e-18 Asthma; BRCA cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.94 -0.3 9.31e-15 Total body bone mineral density; BRCA cis rs9549367 0.789 rs57747440 chr13:113894750 C/A cg18105134 chr13:113819100 PROZ -0.63 -14.22 -0.49 4.32e-40 Platelet distribution width; BRCA cis rs9616064 0.740 rs6520049 chr22:46996309 C/T cg05621596 chr22:47072043 GRAMD4 -0.37 -8.4 -0.32 2.95e-16 Urate levels in obese individuals; BRCA cis rs6964587 1.000 rs10225885 chr7:91671007 A/G cg17063962 chr7:91808500 NA 0.52 12.36 0.44 1.27e-31 Breast cancer; BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.92 0.6 1.05e-63 Alzheimer's disease; BRCA cis rs3806843 1.000 rs9686540 chr5:140174622 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.8 -0.36 3.32e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs783540 0.967 rs783527 chr15:83285847 C/T cg18393722 chr15:85113863 UBE2QP1 -0.27 -8.35 -0.31 4.19e-16 Schizophrenia; BRCA cis rs9649213 0.502 rs6465680 chr7:98005778 A/G cg21770322 chr7:97807741 LMTK2 0.42 10.94 0.4 1.15e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.4 8.09 0.3 3.12e-15 Bipolar disorder; BRCA cis rs6542838 0.583 rs12712040 chr2:99513416 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.1 -0.3 2.89e-15 Fear of minor pain; BRCA cis rs4803468 1.000 rs3810175 chr19:41904396 C/T cg09537434 chr19:41945824 ATP5SL 0.98 23.49 0.68 2.05e-88 Height; BRCA cis rs10752881 0.967 rs6695746 chr1:182991355 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.89 0.56 3.65e-53 Colorectal cancer; BRCA cis rs12477438 0.501 rs7349217 chr2:99815146 T/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.85 26.47 0.72 8.31e-105 Chronic sinus infection; BRCA cis rs365132 1.000 rs7718874 chr5:176358065 A/G cg16309518 chr5:176445507 NA -0.51 -13.29 -0.47 9.27e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs3849570 0.673 rs13068700 chr3:81975817 G/C cg07356753 chr3:81810745 GBE1 -0.36 -8.35 -0.31 4.36e-16 Waist circumference;Body mass index; BRCA cis rs61990749 0.597 rs176946 chr14:78178439 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.6 9.33 0.35 1.72e-19 Fibroblast growth factor basic levels; BRCA cis rs7811142 0.943 rs66958101 chr7:100074020 G/A cg00814883 chr7:100076585 TSC22D4 -0.54 -11.86 -0.42 1.81e-29 Platelet count; BRCA trans rs1994135 0.617 rs12821909 chr12:33723466 T/C cg26384229 chr12:38710491 ALG10B 0.6 12.16 0.43 9.04e-31 Resting heart rate; BRCA cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.39 8.45 0.32 2.02e-16 Cognitive ability; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg24101359 chr6:42928495 GNMT 0.63 15.5 0.52 3.2e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg04553112 chr3:125709451 NA -0.59 -9.23 -0.34 3.86e-19 Blood pressure (smoking interaction); BRCA cis rs9487051 0.872 rs1320612 chr6:109611990 C/A cg01475377 chr6:109611718 NA -0.6 -16.63 -0.55 7.2e-52 Reticulocyte fraction of red cells; BRCA cis rs1983170 1.000 rs483532 chr1:91980447 A/G cg25838465 chr1:92012736 NA -0.46 -9.16 -0.34 7.12e-19 Eosinophil percentage of white cells; BRCA trans rs2204008 0.666 rs67792345 chr12:38204698 T/C cg06521331 chr12:34319734 NA -0.54 -9.56 -0.35 2.48e-20 Bladder cancer; BRCA cis rs4819052 0.851 rs35871601 chr21:46675214 C/T cg11663144 chr21:46675770 NA -0.61 -14.25 -0.49 3.42e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10751667 0.666 rs7396059 chr11:970490 C/A cg01483505 chr11:975446 AP2A2 0.33 9.16 0.34 7.15e-19 Alzheimer's disease (late onset); BRCA trans rs9951602 0.512 rs12454617 chr18:76656007 C/T cg02800362 chr5:177631904 HNRNPAB 0.78 18.07 0.58 2.81e-59 Obesity-related traits; BRCA cis rs589448 0.902 rs2603090 chr12:69777188 G/A cg14784868 chr12:69753453 YEATS4 0.77 25.11 0.7 2.54e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg05573699 chr3:52720067 GNL3;PBRM1 -0.37 -8.96 -0.33 3.47e-18 Bipolar disorder; BRCA cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12756686 chr19:29218302 NA 0.57 10.93 0.4 1.36e-25 Methadone dose in opioid dependence; BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg16606324 chr3:10149918 C3orf24 0.58 11.69 0.42 1e-28 Alzheimer's disease; BRCA cis rs9467711 0.591 rs3734528 chr6:26022244 A/G cg21479132 chr6:26055353 NA 0.57 8.03 0.3 4.79e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs12474201 1.000 rs12474201 chr2:46921285 C/T cg06386533 chr2:46925753 SOCS5 0.81 18.15 0.58 1.11e-59 Height; BRCA cis rs372883 0.506 rs2832300 chr21:30749315 A/G cg08807101 chr21:30365312 RNF160 0.36 7.96 0.3 7.6e-15 Pancreatic cancer; BRCA cis rs13191362 1.000 rs66529337 chr6:163005662 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.7 11.07 0.4 3.4e-26 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs73001065 0.792 rs17216588 chr19:19664077 C/T cg03709012 chr19:19516395 GATAD2A 0.85 9.27 0.34 2.91e-19 LDL cholesterol; BRCA cis rs7727544 0.735 rs270605 chr5:131651811 C/T cg24060327 chr5:131705240 SLC22A5 -0.47 -9.74 -0.36 5.25e-21 Blood metabolite levels; BRCA cis rs7552404 0.924 rs7535991 chr1:76162624 C/T cg03433033 chr1:76189801 ACADM 0.86 22.18 0.66 2.75e-81 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs9929218 1.000 rs12446407 chr16:68804068 G/A cg04657470 chr2:198365150 HSPE1;HSPD1 -0.66 -13.84 -0.48 2.75e-38 Colorectal cancer; BRCA cis rs7618915 0.501 rs6804145 chr3:52694198 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.99 -0.43 5.2e-30 Bipolar disorder; BRCA trans rs8073060 0.963 rs11080353 chr17:33871281 C/T cg19694781 chr19:47549865 TMEM160 0.6 13.46 0.47 1.59e-36 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs28374715 0.617 rs16971733 chr15:41562030 C/A cg18705301 chr15:41695430 NDUFAF1 -0.56 -12.13 -0.43 1.23e-30 Ulcerative colitis; BRCA cis rs17641971 0.684 rs12680366 chr8:49930674 T/C cg00325661 chr8:49890786 NA 0.35 9.52 0.35 3.62e-20 Blood metabolite levels; BRCA cis rs1801251 1.000 rs283475 chr2:233654381 A/C cg08000102 chr2:233561755 GIGYF2 -0.6 -13.0 -0.46 1.86e-34 Coronary artery disease; BRCA cis rs826838 1.000 rs1719848 chr12:39085586 A/G cg26384229 chr12:38710491 ALG10B -0.62 -16.07 -0.54 4.8e-49 Heart rate; BRCA cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.19 -0.4 1.2e-26 Schizophrenia; BRCA cis rs73242632 1.000 rs73242621 chr4:57818081 A/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.65 7.93 0.3 9.85e-15 Congenital heart disease (maternal effect); BRCA cis rs7264396 0.563 rs2066066 chr20:34329359 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.17 -0.43 8.86e-31 Total cholesterol levels; BRCA cis rs1801251 1.000 rs12478564 chr2:233598340 C/T cg08000102 chr2:233561755 GIGYF2 0.63 13.88 0.48 1.8e-38 Coronary artery disease; BRCA cis rs4718428 0.705 rs4718424 chr7:66376095 G/A cg12165864 chr7:66369176 NA -0.44 -10.03 -0.37 4.4e-22 Corneal structure; BRCA cis rs4363385 0.747 rs10399896 chr1:152975083 T/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.59 -0.35 1.92e-20 Inflammatory skin disease; BRCA cis rs7666738 0.830 rs35276471 chr4:99068691 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs763121 0.819 rs3747173 chr22:39069045 A/G cg06544989 chr22:39130855 UNC84B 0.34 7.94 0.3 9.19e-15 Menopause (age at onset); BRCA cis rs9527 0.545 rs7915816 chr10:104881750 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA cis rs911555 0.755 rs1138400 chr14:103956833 A/G cg24130564 chr14:104152367 KLC1 -0.39 -8.84 -0.33 8.97e-18 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg03709012 chr19:19516395 GATAD2A 0.81 18.91 0.6 1.2e-63 Tonsillectomy; BRCA cis rs7246657 0.653 rs28701616 chr19:37681098 G/A cg23950597 chr19:37808831 NA -0.67 -10.31 -0.38 3.79e-23 Coronary artery calcification; BRCA cis rs6558530 0.626 rs6558524 chr8:1702512 T/G cg19131313 chr8:1704013 NA -0.39 -7.82 -0.3 2.16e-14 Systolic blood pressure; BRCA trans rs9388451 0.626 rs1268074 chr6:126107791 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.52 -12.6 -0.45 1.1e-32 Brugada syndrome; BRCA cis rs3784262 0.934 rs4646611 chr15:58265083 T/C cg12031962 chr15:58353849 ALDH1A2 -0.46 -12.26 -0.44 3.6e-31 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs3741404 0.825 rs7111753 chr11:63942189 A/G cg18225595 chr11:63971243 STIP1 0.59 14.22 0.49 4.44e-40 Platelet count; BRCA cis rs769267 0.931 rs15622 chr19:19468734 G/A cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.45 -0.35 6.4e-20 Tonsillectomy; BRCA cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg26647111 chr11:31128758 NA 0.45 9.64 0.36 1.25e-20 Red blood cell count; BRCA cis rs4665809 0.549 rs7577896 chr2:26524493 C/T cg26119090 chr2:26468346 HADHA;HADHB 0.92 15.23 0.52 6.5e-45 Gut microbiome composition (summer); BRCA trans rs61931739 0.500 rs11053277 chr12:34553835 T/A cg13010199 chr12:38710504 ALG10B 0.43 9.22 0.34 4.33e-19 Morning vs. evening chronotype; BRCA cis rs6912958 0.781 rs7750207 chr6:88303967 A/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.42 -0.32 2.42e-16 Monocyte percentage of white cells; BRCA trans rs11098499 0.866 rs10518329 chr4:120401835 A/G cg25214090 chr10:38739885 LOC399744 0.46 10.69 0.39 1.16e-24 Corneal astigmatism; BRCA cis rs10193935 0.901 rs10179237 chr2:42515501 C/T cg27598129 chr2:42591480 NA -0.67 -11.16 -0.4 1.52e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs7586879 0.593 rs10198356 chr2:25130592 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.28e-28 Body mass index; BRCA cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg03452623 chr4:187889614 NA -0.35 -11.18 -0.4 1.31e-26 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742234 0.590 rs2503863 chr10:43667398 G/A cg02780029 chr10:43622663 RET -0.35 -7.81 -0.3 2.42e-14 Hirschsprung disease; BRCA cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg10523679 chr1:76189770 ACADM 0.76 15.75 0.53 1.8e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17345786 0.861 rs17402964 chr3:101067945 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.42 9.04 0.34 1.81e-18 Colonoscopy-negative controls vs population controls; BRCA cis rs3768617 0.510 rs20563 chr1:183085755 C/T ch.1.3577855R chr1:183094577 LAMC1 -0.65 -17.28 -0.56 3.53e-55 Fuchs's corneal dystrophy; BRCA cis rs6121246 0.512 rs6060938 chr20:30363645 T/C cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA cis rs4948102 0.924 rs13241866 chr7:56090878 C/G cg09872392 chr7:56161020 PHKG1 -0.38 -8.96 -0.33 3.49e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs4363385 0.720 rs1338178 chr1:152981550 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs10751667 0.643 rs7396951 chr11:927355 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg15704280 chr7:45808275 SEPT13 0.7 14.41 0.5 5.45e-41 Coronary artery disease; BRCA cis rs7412746 0.658 rs10305704 chr1:150804429 A/C cg18016565 chr1:150552671 MCL1 0.35 8.12 0.31 2.45e-15 Melanoma; BRCA cis rs7903847 0.642 rs7088410 chr10:99135539 G/T cg20016023 chr10:99160130 RRP12 -0.27 -8.67 -0.32 3.62e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs12541635 0.677 rs10808408 chr8:107005034 C/T cg10147462 chr8:107024639 NA 0.39 10.7 0.39 1.07e-24 Age of smoking initiation; BRCA cis rs17209837 0.646 rs10452935 chr7:87094247 A/T cg00919237 chr7:87102261 ABCB4 -0.55 -10.73 -0.39 7.91e-25 Gallbladder cancer; BRCA cis rs12760731 0.565 rs77024410 chr1:178164121 A/C cg00404053 chr1:178313656 RASAL2 0.64 7.85 0.3 1.75e-14 Obesity-related traits; BRCA cis rs4595586 0.525 rs10506132 chr12:39404599 C/T cg26384229 chr12:38710491 ALG10B 0.55 11.75 0.42 5.1e-29 Morning vs. evening chronotype; BRCA cis rs7662987 0.517 rs2602865 chr4:100034841 T/C cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs3820928 0.874 rs116652884 chr2:227902285 C/T cg11843606 chr2:227700838 RHBDD1 -0.36 -7.9 -0.3 1.2e-14 Pulmonary function; BRCA cis rs7072216 0.763 rs733346 chr10:100164325 A/C cg26618903 chr10:100175079 PYROXD2 -0.29 -8.5 -0.32 1.38e-16 Metabolite levels; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg16606324 chr3:10149918 C3orf24 0.49 9.82 0.36 2.67e-21 Alzheimer's disease; BRCA cis rs2239547 0.603 rs4687698 chr3:53097108 C/T cg11645453 chr3:52864694 ITIH4 0.41 9.84 0.36 2.28e-21 Schizophrenia; BRCA trans rs561341 1.000 rs2470243 chr17:30290955 C/T cg20587970 chr11:113659929 NA -1.34 -24.49 -0.7 6.49e-94 Hip circumference adjusted for BMI; BRCA cis rs7714584 1.000 rs3900064 chr5:150264414 C/G cg22134413 chr5:150180641 NA -0.56 -8.53 -0.32 1.08e-16 Crohn's disease; BRCA cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg05283184 chr6:79620031 NA -0.35 -7.88 -0.3 1.4e-14 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs13081177 chr3:134289860 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.85e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg02551604 chr5:131831745 NA 0.42 15.89 0.53 3.71e-48 Asthma (sex interaction); BRCA cis rs7246657 0.941 rs10418729 chr19:37737065 A/C cg18154014 chr19:37997991 ZNF793 0.56 10.28 0.38 4.82e-23 Coronary artery calcification; BRCA cis rs1153858 1.000 rs56669689 chr15:45637729 A/C cg14582100 chr15:45693742 SPATA5L1 0.36 11.95 0.43 7.75e-30 Homoarginine levels; BRCA cis rs698833 1.000 rs1067352 chr2:44669724 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.95 0.33 3.9e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg11707556 chr5:10655725 ANKRD33B -0.45 -9.84 -0.36 2.21e-21 Height; BRCA cis rs3733585 0.673 rs4459990 chr4:9954005 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.53e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12541635 0.934 rs62527400 chr8:107054229 G/A cg10147462 chr8:107024639 NA 0.37 9.67 0.36 9.83e-21 Age of smoking initiation; BRCA cis rs6121246 0.909 rs6119725 chr20:30385557 G/T cg13852791 chr20:30311386 BCL2L1 0.84 16.41 0.54 9.67e-51 Mean corpuscular hemoglobin; BRCA cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg24977027 chr2:88469347 THNSL2 0.57 9.56 0.35 2.42e-20 Plasma clusterin levels; BRCA cis rs10504229 0.645 rs56670121 chr8:58138872 C/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.85 -0.33 8.28e-18 Developmental language disorder (linguistic errors); BRCA cis rs2066819 1.000 rs57279772 chr12:56698960 G/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs6582630 0.555 rs11180986 chr12:38264486 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.91 -0.37 1.2e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs7586879 0.964 rs6545795 chr2:25116783 C/T cg01884057 chr2:25150051 NA 0.32 8.16 0.31 1.83e-15 Body mass index; BRCA cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs11123610 0.520 rs7576146 chr2:3718393 A/C cg19052272 chr2:3704530 ALLC -0.45 -10.09 -0.37 2.64e-22 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs10782582 0.522 rs12125933 chr1:76130920 C/T cg03433033 chr1:76189801 ACADM -0.47 -8.94 -0.33 4e-18 Daytime sleep phenotypes; BRCA cis rs4665809 0.590 rs2289019 chr2:26420809 G/C cg08470875 chr2:26401718 FAM59B -0.72 -11.43 -0.41 1.14e-27 Gut microbiome composition (summer); BRCA cis rs870825 0.616 rs7683615 chr4:185618373 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs7917772 0.604 rs10883756 chr10:104400112 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.38 -10.16 -0.37 1.45e-22 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7904368 0.951 rs7074647 chr10:16855455 T/C cg23933602 chr10:16859644 RSU1 0.59 10.55 0.39 4.18e-24 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA trans rs9393777 0.920 rs34953377 chr6:27381660 T/C cg01620082 chr3:125678407 NA -0.7 -9.15 -0.34 7.58e-19 Intelligence (multi-trait analysis); BRCA trans rs3780486 0.846 rs2209948 chr9:33138247 G/A cg04842962 chr6:43655489 MRPS18A 1.12 38.91 0.84 1.05e-170 IgG glycosylation; BRCA cis rs60871478 1.000 rs34086011 chr7:805430 C/T cg05535760 chr7:792225 HEATR2 0.71 12.97 0.46 2.67e-34 Cerebrospinal P-tau181p levels; BRCA cis rs910316 1.000 rs12889472 chr14:75543979 A/G cg08847533 chr14:75593920 NEK9 0.94 23.79 0.69 4.48e-90 Height; BRCA cis rs12893668 0.572 rs12590968 chr14:104136633 G/C cg26031613 chr14:104095156 KLC1 -0.53 -9.42 -0.35 8.09e-20 Reticulocyte count; BRCA cis rs858239 0.539 rs2178140 chr7:23191625 G/C cg23682824 chr7:23144976 KLHL7 0.41 10.92 0.4 1.41e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs7618915 0.547 rs1561337 chr3:52659963 C/T cg18404041 chr3:52824283 ITIH1 -0.42 -12.31 -0.44 2.14e-31 Bipolar disorder; BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 16.48 0.55 4.22e-51 Platelet count; BRCA cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg11266682 chr4:10021025 SLC2A9 0.49 13.11 0.46 5.99e-35 Bone mineral density; BRCA cis rs13046373 0.535 rs7276743 chr21:31984545 C/T cg16812893 chr21:31813075 KRTAP15-1 0.37 8.92 0.33 4.87e-18 HDL cholesterol; BRCA cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg16489826 chr6:160211363 TCP1;MRPL18 0.64 14.7 0.5 2.42e-42 Age-related macular degeneration (geographic atrophy); BRCA cis rs9986765 1.000 rs76467433 chr7:142824852 C/T cg22531018 chr7:142981779 TMEM139 0.65 10.31 0.38 3.6e-23 Cancer;Dermatomyositis; BRCA cis rs17376456 0.877 rs28539612 chr5:93499099 C/T cg21475434 chr5:93447410 FAM172A 0.72 8.96 0.33 3.63e-18 Diabetic retinopathy; BRCA cis rs9633740 0.945 rs6586030 chr10:82254047 C/T cg01528321 chr10:82214614 TSPAN14 -1.03 -17.24 -0.56 5.59e-55 Post bronchodilator FEV1; BRCA trans rs1005277 0.579 rs2472176 chr10:38382921 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.57 -0.32 7.8e-17 Extrinsic epigenetic age acceleration; BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg09177884 chr7:1199841 ZFAND2A -0.42 -8.99 -0.34 2.82e-18 Longevity;Endometriosis; BRCA cis rs911555 0.755 rs11627446 chr14:103946450 G/C cg12935359 chr14:103987150 CKB -0.61 -13.91 -0.48 1.27e-38 Intelligence (multi-trait analysis); BRCA cis rs558133 0.964 rs6860725 chr5:78419809 C/T cg25119155 chr5:78426943 BHMT -0.45 -9.84 -0.36 2.38e-21 Blood and toenail selenium levels; BRCA trans rs4650994 0.967 rs4650998 chr1:178531850 G/A cg05059571 chr16:84539110 KIAA1609 -0.38 -8.53 -0.32 1.04e-16 HDL cholesterol levels;HDL cholesterol; BRCA cis rs60871478 1.000 rs6460801 chr7:810506 T/C cg27478167 chr7:817139 HEATR2 -0.48 -9.97 -0.37 7.14e-22 Cerebrospinal P-tau181p levels; BRCA cis rs60871478 0.636 rs12534606 chr7:895928 A/G cg13798912 chr7:905769 UNC84A -0.49 -7.9 -0.3 1.18e-14 Cerebrospinal P-tau181p levels; BRCA cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.69 0.39 1.17e-24 Chronic sinus infection; BRCA cis rs7945705 0.846 rs905290 chr11:8753729 A/G cg21881798 chr11:8931708 C11orf17;ST5 0.52 10.71 0.39 9.48e-25 Hemoglobin concentration; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg04944784 chr2:26401820 FAM59B -0.97 -14.88 -0.51 3.18e-43 Gut microbiome composition (summer); BRCA cis rs7586673 0.866 rs747003 chr2:161916409 C/T cg16506815 chr2:162101123 NA -0.41 -8.62 -0.32 5.26e-17 Intelligence (multi-trait analysis); BRCA cis rs8062405 1.000 rs8055138 chr16:28891465 C/T cg16576597 chr16:28551801 NUPR1 0.29 8.23 0.31 1.02e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2832191 1.000 rs2832190 chr21:30488226 G/A cg24692254 chr21:30365293 RNF160 -0.59 -15.06 -0.51 4.31e-44 Dental caries; BRCA cis rs2842992 0.830 rs2025190 chr6:160138241 C/T cg11366901 chr6:160182831 ACAT2 0.81 16.05 0.54 5.82e-49 Age-related macular degeneration (geographic atrophy); BRCA cis rs6484504 0.652 rs485265 chr11:31407788 G/A cg14844989 chr11:31128820 NA 0.44 9.37 0.35 1.27e-19 Red blood cell count; BRCA cis rs796364 0.813 rs4672686 chr2:201065044 A/G cg23649088 chr2:200775458 C2orf69 0.62 10.74 0.39 7.54e-25 Schizophrenia; BRCA cis rs1707322 0.821 rs11211182 chr1:46240170 G/A cg06784218 chr1:46089804 CCDC17 0.5 11.87 0.42 1.7e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9831754 0.906 rs2089934 chr3:78382448 T/C cg06138941 chr3:78371609 NA -0.77 -16.81 -0.55 9.21e-53 Calcium levels; BRCA cis rs2303759 0.918 rs9749416 chr19:49885005 G/A cg05022225 chr19:49866942 DKKL1;TEAD2 0.38 8.56 0.32 8.46e-17 Multiple sclerosis; BRCA cis rs9814567 1.000 rs9990351 chr3:134239191 A/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.39 9.25 0.34 3.26e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg22920501 chr2:26401640 FAM59B -0.68 -11.67 -0.42 1.14e-28 Gut microbiome composition (summer); BRCA cis rs6820391 0.816 rs10016971 chr4:54444792 G/C cg04173182 chr4:54446035 LNX1 0.54 12.06 0.43 2.62e-30 Cervical artery dissection; BRCA cis rs7618915 0.547 rs2286800 chr3:52778051 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.8 0.39 4.48e-25 Bipolar disorder; BRCA cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg26384229 chr12:38710491 ALG10B 0.75 17.25 0.56 4.78e-55 Bladder cancer; BRCA cis rs61931739 0.500 rs11053198 chr12:34444013 G/C cg06521331 chr12:34319734 NA -0.52 -10.24 -0.38 6.79e-23 Morning vs. evening chronotype; BRCA cis rs2835872 0.932 rs73222345 chr21:39036569 G/A cg06728970 chr21:39037746 KCNJ6 -0.32 -7.81 -0.3 2.37e-14 Electroencephalographic traits in alcoholism; BRCA cis rs36051895 0.664 rs3824433 chr9:5113577 C/T cg02405213 chr9:5042618 JAK2 -0.47 -9.01 -0.34 2.34e-18 Pediatric autoimmune diseases; BRCA cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg11266682 chr4:10021025 SLC2A9 0.39 10.25 0.38 6.11e-23 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs8002861 0.870 rs1348671 chr13:44449505 C/T cg17145862 chr1:211918768 LPGAT1 0.66 16.85 0.55 5.39e-53 Leprosy; BRCA cis rs1129187 0.791 rs1129186 chr6:42932202 C/T cg13397359 chr6:42928475 GNMT 0.67 16.29 0.54 3.89e-50 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA cis rs9649213 0.574 rs34717219 chr7:97962271 A/C cg21770322 chr7:97807741 LMTK2 0.42 11.06 0.4 3.78e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs7267979 0.789 rs9927 chr20:25277244 A/G cg08601574 chr20:25228251 PYGB 0.35 8.12 0.31 2.4e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs933688 1.000 rs889213 chr5:90682151 C/T cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 18.9 0.6 1.21e-63 Smoking behavior; BRCA cis rs17253792 0.731 rs8008528 chr14:56062052 C/T cg01858014 chr14:56050164 KTN1 -0.73 -9.19 -0.34 5.56e-19 Putamen volume; BRCA cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg22920501 chr2:26401640 FAM59B 0.57 9.73 0.36 5.95e-21 Gut microbiome composition (summer); BRCA cis rs35306767 0.761 rs1871621 chr10:1049596 C/T cg26597838 chr10:835615 NA 0.95 14.86 0.51 4.14e-43 Eosinophil percentage of granulocytes; BRCA cis rs651907 0.557 rs7651406 chr3:101393296 C/T cg12386194 chr3:101231763 SENP7 0.39 8.41 0.32 2.71e-16 Colorectal cancer; BRCA cis rs9611565 0.659 rs1810460 chr22:41927700 C/T cg06634786 chr22:41940651 POLR3H -0.56 -9.98 -0.37 6.62e-22 Vitiligo; BRCA cis rs68170813 0.559 rs12533767 chr7:106860245 A/C cg02696742 chr7:106810147 HBP1 -0.51 -8.31 -0.31 5.71e-16 Coronary artery disease; BRCA cis rs7703051 0.513 rs59014134 chr5:74589385 C/T cg19683494 chr5:74908142 NA 0.54 8.78 0.33 1.5e-17 LDL cholesterol;Age-related disease endophenotypes;Age-related diseases, mortality and associated endophenotypes; BRCA cis rs7647973 0.667 rs4241405 chr3:49642027 C/T cg03060546 chr3:49711283 APEH 0.58 9.49 0.35 4.62e-20 Menarche (age at onset); BRCA cis rs67460515 0.892 rs4856769 chr3:161004549 C/A cg03342759 chr3:160939853 NMD3 -0.8 -17.17 -0.56 1.24e-54 Parkinson's disease; BRCA cis rs13046373 0.535 rs2832964 chr21:32014012 A/C cg16812893 chr21:31813075 KRTAP15-1 0.37 9.42 0.35 7.84e-20 HDL cholesterol; BRCA cis rs939658 0.626 rs11631406 chr15:79445789 C/T cg17916960 chr15:79447300 NA -0.38 -9.51 -0.35 3.7e-20 Refractive error; BRCA cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg06627628 chr2:24431161 ITSN2 -0.56 -10.9 -0.4 1.72e-25 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg17747265 chr1:1875780 NA 0.51 15.05 0.51 4.71e-44 Body mass index; BRCA cis rs826838 0.967 rs6580726 chr12:39108623 T/C cg26384229 chr12:38710491 ALG10B -0.63 -16.48 -0.55 4.35e-51 Heart rate; BRCA cis rs8072100 1.000 rs4794048 chr17:45763073 A/C cg25173405 chr17:45401733 C17orf57 -0.49 -10.53 -0.38 5.0600000000000004e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.37 8.69 0.33 3.09e-17 Tonsillectomy; BRCA cis rs6582630 0.519 rs11495700 chr12:38288240 A/G cg26384229 chr12:38710491 ALG10B 0.76 17.24 0.56 5.65e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.800 rs2839836 chr4:98970512 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4563143 0.675 rs34113156 chr19:29270822 G/A cg04546413 chr19:29218101 NA 0.64 12.33 0.44 1.75e-31 Methadone dose in opioid dependence; BRCA cis rs270601 0.721 rs162894 chr5:131611872 T/G cg18301423 chr5:131593218 PDLIM4 0.34 7.83 0.3 2.05e-14 Acylcarnitine levels; BRCA cis rs9807989 0.507 rs10203558 chr2:103027640 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.33 0.31 4.8e-16 Asthma; BRCA cis rs11864453 1.000 rs7185407 chr16:72034957 A/T cg01557791 chr16:72042693 DHODH 0.5 11.15 0.4 1.65e-26 Fibrinogen levels; BRCA cis rs477895 0.639 rs35858916 chr11:63950529 T/G cg23719950 chr11:63933701 MACROD1 -0.58 -9.45 -0.35 6.44e-20 Mean platelet volume; BRCA cis rs2625529 0.652 rs8027164 chr15:72407733 A/T cg16672083 chr15:72433130 SENP8 0.67 16.09 0.54 3.72e-49 Red blood cell count; BRCA cis rs10504229 0.645 rs6995814 chr8:58114159 C/T cg20607798 chr8:58055168 NA 0.46 7.93 0.3 9.69e-15 Developmental language disorder (linguistic errors); BRCA cis rs10782582 0.593 rs74968421 chr1:76233496 T/C cg03433033 chr1:76189801 ACADM -0.44 -8.89 -0.33 6.2e-18 Daytime sleep phenotypes; BRCA cis rs9467773 1.000 rs2208331 chr6:26507319 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.25 0.59 3.12e-60 Intelligence (multi-trait analysis); BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg04234412 chr22:24373322 LOC391322 -0.62 -15.42 -0.52 7.41e-46 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs9443645 0.810 rs9443637 chr6:79714708 C/T cg18132916 chr6:79620363 NA -0.44 -9.88 -0.36 1.55e-21 Intelligence (multi-trait analysis); BRCA cis rs311392 0.833 rs6473917 chr8:55090430 A/G cg11783602 chr8:55087084 NA -0.31 -9.24 -0.34 3.74e-19 Pelvic organ prolapse (moderate/severe); BRCA cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.31 9.28 0.34 2.58e-19 Bipolar disorder; BRCA cis rs7586879 0.616 rs6722587 chr2:25132192 C/A cg01884057 chr2:25150051 NA 0.34 9.13 0.34 8.63e-19 Body mass index; BRCA cis rs6138458 1.000 rs1977540 chr20:24900290 G/T cg26195577 chr20:24973756 C20orf3 -0.98 -24.65 -0.7 8.06e-95 Blood protein levels; BRCA cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Urate levels; BRCA cis rs977987 0.806 rs11643410 chr16:75428306 C/T cg03315344 chr16:75512273 CHST6 0.53 12.55 0.44 1.91e-32 Dupuytren's disease; BRCA cis rs1707322 1.000 rs11211204 chr1:46317864 A/G cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.65e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg02951883 chr7:2050386 MAD1L1 -0.51 -11.9 -0.43 1.24e-29 Bipolar disorder and schizophrenia; BRCA cis rs2652834 1.000 rs34575783 chr15:63397686 G/C cg05507819 chr15:63340323 TPM1 0.44 8.05 0.3 4.07e-15 HDL cholesterol; BRCA cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg14664628 chr15:75095509 CSK -0.52 -12.46 -0.44 4.81e-32 Breast cancer; BRCA cis rs3096299 0.933 rs2965934 chr16:89481229 C/G cg08822215 chr16:89438651 ANKRD11 -0.41 -8.89 -0.33 6.37e-18 Multiple myeloma (IgH translocation); BRCA cis rs7267979 0.966 rs2257705 chr20:25264664 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.87 0.36 1.75e-21 Liver enzyme levels (alkaline phosphatase); BRCA trans rs208520 0.526 rs9363522 chr6:66816642 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.13 -38.25 -0.83 2.23e-167 Exhaled nitric oxide output; BRCA cis rs6728642 0.614 rs113485946 chr2:97866442 T/C cg26665480 chr2:98280029 ACTR1B -0.66 -7.95 -0.3 8.34e-15 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs9487051 0.872 rs1111863 chr6:109611206 C/T cg01475377 chr6:109611718 NA 0.58 15.91 0.53 3.06e-48 Reticulocyte fraction of red cells; BRCA cis rs1953600 0.870 rs2788295 chr10:81941007 C/G cg04850286 chr10:81895943 PLAC9 0.32 9.07 0.34 1.5e-18 Sarcoidosis; BRCA cis rs208520 0.754 rs12204635 chr6:66740779 C/A cg07460842 chr6:66804631 NA 0.99 19.85 0.62 1.08e-68 Exhaled nitric oxide output; BRCA cis rs4665809 0.590 rs11552518 chr2:26455127 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.93 0.37 1.03e-21 Gut microbiome composition (summer); BRCA cis rs10464366 0.544 rs2280667 chr7:39172228 A/C cg15212455 chr7:39170539 POU6F2 0.43 9.61 0.36 1.68e-20 IgG glycosylation; BRCA cis rs72781680 0.898 rs17462670 chr2:24026579 T/C cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs9463078 0.803 rs9463083 chr6:45272062 T/G cg25276700 chr6:44698697 NA -0.36 -8.14 -0.31 2.01e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs7103648 0.695 rs11039290 chr11:47572279 G/A cg20307385 chr11:47447363 PSMC3 0.8 19.12 0.6 8.23e-65 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.33 0.35 1.68e-19 Alzheimer's disease; BRCA cis rs589448 0.900 rs588493 chr12:69751986 G/A cg20891283 chr12:69753455 YEATS4 0.84 28.1 0.74 9.91e-114 Cerebrospinal fluid biomarker levels; BRCA cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg24642439 chr20:33292090 TP53INP2 0.53 11.49 0.41 6.56e-28 Glomerular filtration rate (creatinine); BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18402987 chr7:1209562 NA 0.65 14.8 0.51 7.44e-43 Longevity;Endometriosis; BRCA cis rs6088580 0.634 rs945673 chr20:32964265 C/A cg06115741 chr20:33292138 TP53INP2 -0.37 -8.28 -0.31 7.13e-16 Glomerular filtration rate (creatinine); BRCA cis rs910316 1.000 rs876402 chr14:75601862 C/T cg08847533 chr14:75593920 NEK9 -0.93 -24.74 -0.7 2.81e-95 Height; BRCA cis rs6500602 0.609 rs7202910 chr16:4518948 T/A cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.35 0.31 4.19e-16 Schizophrenia; BRCA cis rs62244186 0.535 rs59726036 chr3:44850074 G/T cg15225532 chr3:44803084 KIF15;KIAA1143 0.37 7.82 0.3 2.25e-14 Depressive symptoms; BRCA cis rs78707713 0.560 rs61848398 chr10:71226103 G/A cg12610070 chr10:71211762 TSPAN15 -0.33 -10.2 -0.37 9.84e-23 Venous thromboembolism; BRCA cis rs9311474 0.508 rs7614498 chr3:52618941 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.84 -0.3 1.91e-14 Electroencephalogram traits; BRCA cis rs2282526 0.615 rs463738 chr21:44921166 G/A cg01579765 chr21:45077557 HSF2BP 0.38 8.96 0.33 3.54e-18 Mean corpuscular hemoglobin; BRCA cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg21427119 chr20:30132790 HM13 -0.41 -8.78 -0.33 1.53e-17 Mean corpuscular hemoglobin; BRCA cis rs6952808 1.000 rs6954521 chr7:1886865 C/A cg21782813 chr7:2030301 MAD1L1 0.39 10.18 0.37 1.22e-22 Bipolar disorder and schizophrenia; BRCA cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.26 0.31 8.22e-16 Aortic root size; BRCA cis rs9381040 0.655 rs9394756 chr6:41016183 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.41 -8.82 -0.33 1.05e-17 Alzheimer's disease (late onset); BRCA cis rs7917772 0.503 rs1536308 chr10:104288777 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.35 0.59 9.88e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs73086581 1.000 rs3746665 chr20:3910406 C/T cg02187196 chr20:3869020 PANK2 -0.51 -9.69 -0.36 8.25e-21 Response to antidepressants in depression; BRCA cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6089829 0.889 rs6090206 chr20:61668363 G/A cg02544614 chr20:61657117 NA 0.29 8.2 0.31 1.36e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg11766577 chr21:47581405 C21orf56 -0.5 -10.79 -0.39 4.75e-25 Testicular germ cell tumor; BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg21782813 chr7:2030301 MAD1L1 0.4 10.74 0.39 7.59e-25 Bipolar disorder and schizophrenia; BRCA cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.38 0.31 3.28e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs7618501 1.000 rs1491986 chr3:49739086 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.56 -0.39 3.73e-24 Intelligence (multi-trait analysis); BRCA trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21659725 chr3:3221576 CRBN 0.5 12.9 0.45 5.2e-34 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs4819038 chr21:46659393 C/T cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs312274 0.515 rs10784901 chr12:41232263 C/A cg17827154 chr12:41323612 CNTN1 0.36 9.01 0.34 2.43e-18 Metabolite levels (X-11787); BRCA cis rs7618501 0.699 rs2777888 chr3:49898000 A/G cg24110177 chr3:50126178 RBM5 -0.37 -9.91 -0.36 1.26e-21 Intelligence (multi-trait analysis); BRCA cis rs9467773 0.844 rs2393669 chr6:26503873 C/T cg11502198 chr6:26597334 ABT1 0.47 9.48 0.35 4.75e-20 Intelligence (multi-trait analysis); BRCA cis rs5167 0.504 rs7258345 chr19:45453151 T/G cg09555818 chr19:45449301 APOC2 0.47 12.22 0.44 5.19e-31 Blood protein levels; BRCA cis rs8058578 0.832 rs7500719 chr16:30840877 C/T cg02466173 chr16:30829666 NA -0.47 -10.31 -0.38 3.66e-23 Multiple myeloma; BRCA cis rs16958440 0.867 rs114475395 chr18:44691010 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs2032447 0.575 rs198847 chr6:26106619 C/A cg03517284 chr6:25882590 NA 0.37 7.88 0.3 1.46e-14 Intelligence (multi-trait analysis); BRCA cis rs4919087 0.962 rs3814164 chr10:98982749 G/A cg25902810 chr10:99078978 FRAT1 0.41 8.82 0.33 1.07e-17 Monocyte count; BRCA cis rs7552404 1.000 rs4949876 chr1:76173377 C/T cg03433033 chr1:76189801 ACADM 0.76 17.35 0.57 1.59e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs3733585 0.673 rs116046986 chr4:9957794 A/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.47 -0.38 9.07e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9733 0.596 rs72702557 chr1:150680130 A/G cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs708547 0.874 rs1401190 chr4:57885174 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.51 12.16 0.43 9.75e-31 Response to bleomycin (chromatid breaks); BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg11141652 chr22:24348549 GSTTP1 0.38 7.89 0.3 1.31e-14 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg07606381 chr6:8435919 SLC35B3 -0.64 -13.99 -0.48 5.64e-39 Motion sickness; BRCA cis rs3784262 0.669 rs2197092 chr15:58247781 C/T cg12031962 chr15:58353849 ALDH1A2 0.36 10.13 0.37 1.8e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.83 14.26 0.49 2.91e-40 Alzheimer's disease; BRCA cis rs11024102 0.830 rs11024110 chr11:17028390 T/A cg15084286 chr11:17036142 PLEKHA7 0.49 8.8 0.33 1.32e-17 Glaucoma (primary angle closure); BRCA cis rs4481887 0.861 rs6669290 chr1:248476804 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.55 0.32 9.35e-17 Common traits (Other); BRCA cis rs10752881 1.000 rs12028732 chr1:182985525 G/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.72 0.55 2.67e-52 Colorectal cancer; BRCA cis rs13191362 1.000 rs34918316 chr6:163005386 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.09 0.46 7.48e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13191362 1.000 rs34619021 chr6:163029767 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.51 8.58 0.32 7.26e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg16590910 chr6:42928470 GNMT 0.36 7.89 0.3 1.35e-14 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.16 18.76 0.6 6.96e-63 Platelet count; BRCA cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs2197308 0.631 rs4882308 chr12:38446252 G/C cg26384229 chr12:38710491 ALG10B -0.43 -10.07 -0.37 3.08e-22 Morning vs. evening chronotype; BRCA cis rs6815814 0.950 rs45588337 chr4:38807328 A/G cg06935464 chr4:38784597 TLR10 0.51 8.42 0.32 2.52e-16 Breast cancer; BRCA cis rs896854 0.625 rs7823886 chr8:95986459 A/T cg16049864 chr8:95962084 TP53INP1 -0.43 -10.59 -0.39 3.05e-24 Type 2 diabetes; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg00802000 chr16:706648 WDR90 -0.41 -9.56 -0.35 2.48e-20 Height; BRCA cis rs4268898 0.760 rs55863105 chr2:24570695 C/T cg06627628 chr2:24431161 ITSN2 0.42 8.82 0.33 1.12e-17 Asthma; BRCA cis rs1215050 0.791 rs548892 chr4:98724701 C/T cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.83e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.64 0.32 4.62e-17 Glomerular filtration rate (creatinine); BRCA cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg06618935 chr21:46677482 NA -0.36 -8.14 -0.31 2.02e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs853679 0.517 rs56364346 chr6:28050762 T/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.15 -0.31 1.9e-15 Depression; BRCA cis rs2797160 1.000 rs2747717 chr6:126008435 A/G cg05901451 chr6:126070800 HEY2 0.4 9.71 0.36 6.73e-21 Endometrial cancer; BRCA cis rs6912958 0.781 rs985764 chr6:88215206 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.3 -0.31 5.98e-16 Monocyte percentage of white cells; BRCA cis rs10504229 0.679 rs75402323 chr8:58136227 A/G cg08219700 chr8:58056026 NA 0.47 8.56 0.32 8.63e-17 Developmental language disorder (linguistic errors); BRCA cis rs17376456 0.825 rs17372057 chr5:93071916 C/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.58 7.87 0.3 1.56e-14 Diabetic retinopathy; BRCA cis rs4076764 0.535 rs4409627 chr1:163382050 A/G cg06092702 chr1:163392909 NA 0.27 7.98 0.3 6.61e-15 Motion sickness; BRCA cis rs17095355 0.818 rs10509907 chr10:111781715 T/C cg00817464 chr10:111662876 XPNPEP1 -0.45 -9.7 -0.36 7.79e-21 Biliary atresia; BRCA cis rs2243480 0.901 rs778732 chr7:65822360 C/T cg18252515 chr7:66147081 NA -1.06 -15.67 -0.53 4.51e-47 Diabetic kidney disease; BRCA cis rs9368481 0.700 rs6911401 chr6:26913214 C/G cg18278486 chr6:26987575 LOC100270746;C6orf41 0.24 8.31 0.31 5.89e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs9647379 0.712 rs4894808 chr3:171833266 C/G cg16233210 chr3:171778391 FNDC3B 0.35 8.02 0.3 4.92e-15 Heart rate; BRCA cis rs4363385 0.747 rs1338180 chr1:152981404 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.07 -0.34 1.44e-18 Inflammatory skin disease; BRCA cis rs7666738 0.791 rs6851549 chr4:99029827 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.94 0.3 9.1e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4689592 0.503 rs4689064 chr4:7055603 A/G cg06697600 chr4:7070879 GRPEL1 0.63 10.93 0.4 1.27e-25 Monocyte percentage of white cells; BRCA cis rs921968 0.541 rs3821031 chr2:219295249 C/T cg02176678 chr2:219576539 TTLL4 -0.45 -11.71 -0.42 7.97e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs829883 1.000 rs249837 chr12:98876535 A/G cg25150519 chr12:98850993 NA 0.58 11.78 0.42 4.01e-29 Colorectal adenoma (advanced); BRCA cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg18252515 chr7:66147081 NA -0.54 -11.05 -0.4 4.4e-26 Corneal structure; BRCA cis rs6543140 0.964 rs6543143 chr2:103085420 A/C cg04239558 chr2:103089729 SLC9A4 0.35 9.89 0.36 1.52e-21 Blood protein levels; BRCA cis rs4363385 0.747 rs4314835 chr1:152984901 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.35 -0.31 4.16e-16 Inflammatory skin disease; BRCA cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg00958927 chr1:175162553 KIAA0040 -0.21 -7.85 -0.3 1.71e-14 Alcohol dependence; BRCA trans rs12310956 0.532 rs10772114 chr12:33853970 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.47 0.35 5.4e-20 Morning vs. evening chronotype; BRCA cis rs17666538 0.585 rs336444 chr8:633123 C/G cg07234876 chr8:600039 NA -0.69 -9.87 -0.36 1.83e-21 IgG glycosylation; BRCA cis rs2276314 0.857 rs4799409 chr18:33592602 C/T cg05985134 chr18:33552581 C18orf21 0.64 12.21 0.43 5.7e-31 Endometriosis;Drug-induced torsades de pointes; BRCA trans rs11098499 0.863 rs6835635 chr4:120458867 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.38 8.49 0.32 1.39e-16 Corneal astigmatism; BRCA cis rs1862618 0.671 rs72644088 chr5:56241019 G/A cg12311346 chr5:56204834 C5orf35 0.61 12.82 0.45 1.23e-33 Initial pursuit acceleration; BRCA cis rs3858526 0.959 rs4559671 chr11:5923419 C/T cg25319279 chr11:5960081 NA -0.42 -8.23 -0.31 1.05e-15 DNA methylation (variation); BRCA cis rs2032447 0.765 rs1935235 chr6:26067782 C/G cg03517284 chr6:25882590 NA -0.45 -9.44 -0.35 6.8e-20 Intelligence (multi-trait analysis); BRCA cis rs9420 0.961 rs682503 chr11:57640994 C/G cg19752551 chr11:57585705 CTNND1 0.43 10.79 0.39 4.63e-25 Schizophrenia; BRCA cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg27211696 chr2:191398769 TMEM194B 0.52 11.76 0.42 5.03e-29 Pulse pressure; BRCA cis rs701145 0.585 rs1727944 chr3:153826603 A/C cg12800244 chr3:153838788 SGEF -0.62 -7.93 -0.3 1e-14 Coronary artery disease; BRCA cis rs10782582 0.593 rs1412717 chr1:76125471 C/T cg10523679 chr1:76189770 ACADM -0.47 -9.19 -0.34 5.31e-19 Daytime sleep phenotypes; BRCA cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg10523679 chr1:76189770 ACADM 0.77 15.91 0.53 3.01e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2153535 0.580 rs2143355 chr6:8517856 T/A cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 4.74e-18 Motion sickness; BRCA cis rs4400599 0.618 rs9803862 chr1:154192143 A/G cg26808167 chr1:154192205 UBAP2L;C1orf43 0.32 7.93 0.3 1.02e-14 Platelet distribution width; BRCA cis rs801193 1.000 rs2707845 chr7:66198798 C/T cg18876405 chr7:65276391 NA 0.62 15.37 0.52 1.28e-45 Aortic root size; BRCA cis rs2073499 0.935 rs3755832 chr3:50305234 G/A cg05260129 chr3:50388622 TUSC4;CYB561D2 0.6 8.14 0.31 2.03e-15 Schizophrenia; BRCA cis rs7512552 0.839 rs1694385 chr1:150377960 G/A cg15654264 chr1:150340011 RPRD2 0.37 8.16 0.31 1.82e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg11764359 chr7:65958608 NA 0.75 18.31 0.59 1.59e-60 Aortic root size; BRCA cis rs10876993 0.928 rs1689594 chr12:58057156 T/C cg18357645 chr12:58087776 OS9 0.46 13.35 0.47 4.92e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs796364 0.760 rs56225698 chr2:200910653 A/C cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs2549003 1.000 rs2549004 chr5:131827825 C/G cg02551604 chr5:131831745 NA 0.4 15.48 0.52 3.98e-46 Asthma (sex interaction); BRCA cis rs6866344 0.697 rs61247551 chr5:178133503 G/A cg10224037 chr5:178157518 ZNF354A 0.76 16.24 0.54 6.3e-50 Neutrophil percentage of white cells; BRCA cis rs870825 0.616 rs35818632 chr4:185649661 G/T cg04058563 chr4:185651563 MLF1IP 0.87 16.7 0.55 3.23e-52 Blood protein levels; BRCA cis rs769267 0.930 rs4808208 chr19:19650096 A/G cg03709012 chr19:19516395 GATAD2A 0.79 18.0 0.58 6.76e-59 Tonsillectomy; BRCA cis rs4727027 0.899 rs11768971 chr7:148825826 C/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.01 0.4 6.48e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6878727 0.638 rs42267 chr5:123656298 A/G cg01806427 chr5:123737813 NA -0.35 -8.0 -0.3 5.93e-15 Breast cancer; BRCA cis rs67460515 0.500 rs9822435 chr3:160748068 A/T cg03342759 chr3:160939853 NMD3 -0.6 -11.77 -0.42 4.6e-29 Parkinson's disease; BRCA cis rs875971 0.660 rs7807944 chr7:66087195 C/G cg11764359 chr7:65958608 NA -0.67 -14.97 -0.51 1.13e-43 Aortic root size; BRCA cis rs546131 0.928 rs499183 chr11:34836678 A/G cg11058730 chr11:34937778 PDHX;APIP 0.41 8.1 0.31 2.77e-15 Lung disease severity in cystic fibrosis; BRCA cis rs12142240 0.738 rs41293277 chr1:46806550 C/T cg10495392 chr1:46806563 NSUN4 0.46 8.46 0.32 1.82e-16 Menopause (age at onset); BRCA trans rs61931739 0.534 rs814669 chr12:34102459 C/T cg13010199 chr12:38710504 ALG10B 0.4 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs7617773 0.780 rs13084616 chr3:48339699 A/G cg11946769 chr3:48343235 NME6 -0.69 -14.56 -0.5 1.09e-41 Coronary artery disease; BRCA cis rs17270561 0.609 rs4464787 chr6:25733558 G/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.88 0.33 6.52e-18 Iron status biomarkers; BRCA cis rs6484504 0.652 rs494464 chr11:31386150 C/T cg06552810 chr11:31128660 NA 0.37 8.47 0.32 1.69e-16 Red blood cell count; BRCA cis rs7809950 1.000 rs986994 chr7:107104115 G/T cg23024343 chr7:107201750 COG5 -0.39 -8.74 -0.33 2.03e-17 Coronary artery disease; BRCA cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg09165964 chr15:75287851 SCAMP5 -0.85 -20.39 -0.63 1.51e-71 Blood trace element (Zn levels); BRCA cis rs6912958 0.781 rs3757368 chr6:88224495 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.33 -0.31 5.02e-16 Monocyte percentage of white cells; BRCA trans rs7746199 0.736 rs13215275 chr6:27647509 G/T cg06606381 chr12:133084897 FBRSL1 -0.89 -8.8 -0.33 1.28e-17 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs6684428 0.706 rs10493187 chr1:56320969 C/T cg11651538 chr1:56320950 NA -0.45 -7.94 -0.3 8.88e-15 Airflow obstruction; BRCA cis rs4722166 0.695 rs7787893 chr7:22774437 A/G cg26061582 chr7:22766209 IL6 0.38 8.96 0.33 3.62e-18 Lung cancer; BRCA cis rs7727544 0.582 rs10075459 chr5:131541363 C/G cg14196790 chr5:131705035 SLC22A5 0.37 9.06 0.34 1.6e-18 Blood metabolite levels; BRCA cis rs6430585 0.591 rs3098103 chr2:136656094 T/C cg07169764 chr2:136633963 MCM6 1.16 22.46 0.66 8.89e-83 Corneal structure; BRCA cis rs9790314 0.747 rs9820825 chr3:160848155 A/G cg04691961 chr3:161091175 C3orf57 -0.37 -8.18 -0.31 1.49e-15 Morning vs. evening chronotype; BRCA cis rs6089584 0.816 rs6061411 chr20:60634716 C/A cg06108461 chr20:60628389 TAF4 -0.97 -21.8 -0.65 3.32e-79 Body mass index; BRCA cis rs2979489 0.891 rs4733495 chr8:30366883 A/G cg26383811 chr8:30366931 RBPMS 0.56 14.62 0.5 6.03e-42 Mean corpuscular hemoglobin;Plateletcrit;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts;Mean corpuscular volume;Myeloid white cell count;Sum neutrophil eosinophil counts; BRCA cis rs6782228 0.509 rs4481172 chr3:128372657 C/A cg16766828 chr3:128327626 NA -0.43 -9.69 -0.36 8.58e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs9287719 0.781 rs6732671 chr2:10759149 T/G cg00105475 chr2:10696890 NA 0.42 9.61 0.36 1.65e-20 Prostate cancer; BRCA cis rs6743226 0.870 rs67652230 chr2:242235446 A/T cg10021735 chr2:242295487 FARP2 0.37 10.17 0.37 1.24e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs7586879 0.828 rs11685125 chr2:25092104 A/G cg04586622 chr2:25135609 ADCY3 0.38 8.99 0.34 2.76e-18 Body mass index; BRCA cis rs9814567 1.000 rs1498718 chr3:134205920 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.18 -0.34 5.91e-19 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs875971 0.964 rs6945032 chr7:65922486 C/T cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs4892230 1 rs4892230 chr18:72155572 G/A cg26446133 chr18:72167187 CNDP2 -0.54 -11.67 -0.42 1.18e-28 Mononucleosis; BRCA cis rs769267 0.929 rs34538000 chr19:19481379 G/T cg02546618 chr19:19431379 KIAA0892;SF4 -0.39 -9.26 -0.34 2.99e-19 Tonsillectomy; BRCA cis rs8180040 0.620 rs11715121 chr3:47072621 T/A cg16586182 chr3:47516702 SCAP 0.55 12.36 0.44 1.3e-31 Colorectal cancer; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg00106254 chr7:1943704 MAD1L1 -0.46 -12.31 -0.44 2.1e-31 Bipolar disorder and schizophrenia; BRCA cis rs11893307 0.566 rs10203824 chr2:191595850 A/C cg05765582 chr2:191677683 NA 0.44 8.2 0.31 1.31e-15 Mean platelet volume; BRCA cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -10.86 -0.39 2.59e-25 Bipolar disorder; BRCA cis rs9325144 0.624 rs7309400 chr12:39150369 G/C cg26384229 chr12:38710491 ALG10B -0.5 -11.33 -0.41 3.17e-27 Morning vs. evening chronotype; BRCA trans rs6598955 1.000 rs6598955 chr1:26619649 C/T cg07461501 chr17:79650226 HGS;ARL16 -0.4 -10.08 -0.37 2.83e-22 Obesity-related traits; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 18.61 0.59 4.36e-62 Platelet count; BRCA cis rs4862750 0.624 rs34414639 chr4:187873417 C/A cg22105103 chr4:187893119 NA 0.35 10.8 0.39 4.5e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs7756236 0.521 rs6907793 chr6:36625206 A/G cg08179530 chr6:36648295 CDKN1A 0.38 8.19 0.31 1.47e-15 QRS duration; BRCA cis rs7246657 0.722 rs3829688 chr19:38077100 T/C cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs7044106 0.718 rs1960421 chr9:123394894 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 13.81 0.48 3.83e-38 Hip circumference adjusted for BMI; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg22920501 chr2:26401640 FAM59B -0.91 -16.23 -0.54 7.78e-50 Gut microbiome composition (summer); BRCA cis rs6570726 0.935 rs409121 chr6:145839793 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs1215050 0.791 rs260889 chr4:98742340 A/G cg05340658 chr4:99064831 C4orf37 0.45 10.39 0.38 1.79e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2243480 1.000 rs778729 chr7:65824419 T/C cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs2304069 0.913 rs9324637 chr5:149390947 T/C cg10852222 chr5:149380144 HMGXB3;TIGD6 0.56 8.69 0.32 3.15e-17 HIV-1 control; BRCA cis rs425277 0.606 rs424079 chr1:2071340 C/A cg24578937 chr1:2090814 PRKCZ -0.37 -11.81 -0.42 2.86e-29 Height; BRCA cis rs4780401 0.933 rs7203803 chr16:11812291 A/G cg01061890 chr16:11836724 TXNDC11 0.35 7.9 0.3 1.25e-14 Rheumatoid arthritis; BRCA trans rs17685 0.753 rs4398845 chr7:75716781 G/A cg19862616 chr7:65841803 NCRNA00174 0.84 27.72 0.74 1.23e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9470366 0.883 rs12199346 chr6:36641546 C/A cg08179530 chr6:36648295 CDKN1A 0.58 10.88 0.4 2.04e-25 QRS duration; BRCA cis rs11229555 0.645 rs34350060 chr11:58184902 T/C cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg08888203 chr3:10149979 C3orf24 0.68 14.48 0.5 2.55e-41 Alzheimer's disease; BRCA cis rs13040088 0.935 rs62200158 chr20:61557906 C/T cg23096297 chr20:61557774 DIDO1 0.92 19.25 0.61 1.76e-65 Menopause (age at onset); BRCA cis rs9287719 0.674 rs1387566 chr2:10828650 C/T cg00105475 chr2:10696890 NA -0.38 -8.73 -0.33 2.3e-17 Prostate cancer; BRCA cis rs7267979 1.000 rs2257985 chr20:25269743 G/T cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6598955 0.671 rs3924325 chr1:26616320 T/C cg04990556 chr1:26633338 UBXN11 0.55 8.65 0.32 4.23e-17 Obesity-related traits; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg20119798 chr7:94954144 PON1 -0.43 -9.76 -0.36 4.58e-21 Paraoxonase activity; BRCA cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg23711669 chr6:146136114 FBXO30 0.84 20.2 0.62 1.53e-70 Lobe attachment (rater-scored or self-reported); BRCA cis rs1577917 1.000 rs12192992 chr6:86609915 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.19 -0.46 2.63e-35 Response to antipsychotic treatment; BRCA cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.95 -0.3 8.2e-15 Total body bone mineral density; BRCA cis rs1577917 1.000 rs34622557 chr6:86630852 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -12.07 -0.43 2.24e-30 Response to antipsychotic treatment; BRCA cis rs67478160 0.643 rs1535098 chr14:104216513 T/A cg26031613 chr14:104095156 KLC1 -0.42 -8.33 -0.31 4.82e-16 Schizophrenia; BRCA cis rs919433 0.679 rs7600862 chr2:198534514 C/T cg00792783 chr2:198669748 PLCL1 0.39 8.99 0.33 2.83e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7666738 0.712 rs34043080 chr4:99008748 G/C cg05340658 chr4:99064831 C4orf37 0.67 16.67 0.55 4.42e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs561341 1.000 rs483301 chr17:30293398 G/T cg12193833 chr17:30244370 NA -0.58 -8.78 -0.33 1.54e-17 Hip circumference adjusted for BMI; BRCA cis rs10751667 0.600 rs1128419 chr11:1010750 G/A cg10932868 chr11:921992 NA 0.33 7.87 0.3 1.53e-14 Alzheimer's disease (late onset); BRCA cis rs9310732 0.604 rs6797410 chr3:24192284 A/G cg15359321 chr3:24203479 THRB 0.44 10.6 0.39 2.69e-24 Schizophrenia; BRCA cis rs1059312 0.778 rs4760594 chr12:129296865 T/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.79 -19.85 -0.62 1.21e-68 Systemic lupus erythematosus; BRCA cis rs79839061 0.562 rs10516158 chr4:942439 A/G cg14530993 chr4:882597 GAK -0.53 -9.3 -0.35 2.22e-19 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.625 rs9393681 chr6:26008260 A/G cg17691542 chr6:26056736 HIST1H1C 0.5 10.47 0.38 9.13e-24 Height; BRCA cis rs2243480 1.000 rs781142 chr7:65438778 C/T cg18252515 chr7:66147081 NA -0.84 -12.23 -0.44 4.53e-31 Diabetic kidney disease; BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg05863683 chr7:1912471 MAD1L1 -0.34 -7.93 -0.3 1.01e-14 Bipolar disorder and schizophrenia; BRCA cis rs875971 0.545 rs6460276 chr7:65647277 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 10.13 0.37 1.8e-22 Aortic root size; BRCA cis rs11711311 1.000 rs10212375 chr3:113471336 G/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.76 -0.39 6.47e-25 IgG glycosylation; BRCA cis rs1862618 0.671 rs2591964 chr5:56236900 T/G cg22800045 chr5:56110881 MAP3K1 -0.46 -9.05 -0.34 1.66e-18 Initial pursuit acceleration; BRCA cis rs9788682 0.706 rs2568493 chr15:78740233 G/A cg24631222 chr15:78858424 CHRNA5 -0.48 -9.58 -0.35 2.18e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7809950 1.000 rs2520269 chr7:107191327 T/C cg23024343 chr7:107201750 COG5 -0.39 -8.75 -0.33 1.86e-17 Coronary artery disease; BRCA trans rs587242 0.823 rs12025601 chr1:97024285 A/G cg10631902 chr5:14652156 NA -0.35 -8.06 -0.3 3.88e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs9393777 0.513 rs9368450 chr6:26652489 A/C cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.31 -8.05 -0.3 4.16e-15 Intelligence (multi-trait analysis); BRCA cis rs1865721 0.682 rs3745081 chr18:73142923 A/G cg26385618 chr18:73139727 C18orf62 -0.37 -9.06 -0.34 1.62e-18 Intelligence; BRCA cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg13770153 chr20:60521292 NA 0.81 20.25 0.63 7.72e-71 Obesity-related traits; BRCA cis rs12711979 0.509 rs13021385 chr2:3826387 T/C cg17052675 chr2:3827356 NA -0.69 -23.53 -0.68 1.21e-88 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs400736 0.894 rs225092 chr1:8036075 G/C cg25007680 chr1:8021821 PARK7 0.48 12.03 0.43 3.55e-30 Response to antidepressants and depression; BRCA trans rs10411161 0.702 rs8110546 chr19:52383556 C/A cg22319618 chr22:45562946 NUP50 -0.41 -7.84 -0.3 1.95e-14 Breast cancer; BRCA trans rs7613875 0.600 rs2247510 chr3:50126215 A/C cg21659725 chr3:3221576 CRBN 0.35 8.68 0.32 3.27e-17 Body mass index; BRCA cis rs614226 0.516 rs1794748 chr12:120953758 A/G cg27489772 chr12:121021490 NA 0.44 7.95 0.3 8.79e-15 Type 1 diabetes nephropathy; BRCA cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.76e-18 Motion sickness; BRCA cis rs870825 0.550 rs59051283 chr4:185646476 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.84 0.58 4.63e-58 Blood protein levels; BRCA cis rs2204008 0.837 rs12366727 chr12:38365748 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.12 0.37 1.94e-22 Bladder cancer; BRCA cis rs1008375 0.966 rs6813375 chr4:17649499 T/G cg02297831 chr4:17616191 MED28 0.38 8.9 0.33 5.66e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 0.863 rs10009626 chr4:120470005 T/C cg25214090 chr10:38739885 LOC399744 0.55 12.09 0.43 1.97e-30 Corneal astigmatism; BRCA cis rs6500602 0.701 rs4785969 chr16:4536934 A/T cg08645402 chr16:4508243 NA 0.42 9.6 0.36 1.71e-20 Schizophrenia; BRCA cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -8.48 -0.32 1.58e-16 Intelligence (multi-trait analysis); BRCA cis rs853679 0.517 rs6932109 chr6:28078303 A/G cg02631126 chr6:28058918 ZSCAN12L1 -0.27 -8.16 -0.31 1.83e-15 Depression; BRCA cis rs7296418 0.961 rs1727307 chr12:123575742 A/G cg02203224 chr12:123464087 ARL6IP4;OGFOD2 -0.34 -7.87 -0.3 1.51e-14 Platelet count; BRCA cis rs7666738 0.716 rs13108535 chr4:99046324 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs10791323 0.572 rs10894755 chr11:133739685 C/T cg14349672 chr11:133703707 NA 0.38 8.72 0.33 2.32e-17 Childhood ear infection; BRCA cis rs11098499 0.954 rs71614438 chr4:120371252 G/A cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.48 9.13 0.34 9.23e-19 Gut microbiome composition (summer); BRCA cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.38e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9311474 0.581 rs13621 chr3:52558133 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.39 8.4 0.32 2.89e-16 Electroencephalogram traits; BRCA cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg11890956 chr21:40555474 PSMG1 -0.62 -13.91 -0.48 1.27e-38 Menarche (age at onset); BRCA cis rs2832191 0.511 rs7278227 chr21:30482707 C/T cg08807101 chr21:30365312 RNF160 -0.42 -9.42 -0.35 7.82e-20 Dental caries; BRCA cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg02297831 chr4:17616191 MED28 0.37 8.68 0.32 3.41e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs208520 0.779 rs208446 chr6:66903515 T/C cg07460842 chr6:66804631 NA -0.89 -15.26 -0.52 4.77e-45 Exhaled nitric oxide output; BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.74 16.37 0.54 1.48e-50 Lymphocyte counts; BRCA cis rs10484885 0.752 rs72921948 chr6:90582560 T/C cg13799429 chr6:90582589 CASP8AP2 -0.88 -17.0 -0.56 9.97e-54 QRS interval (sulfonylurea treatment interaction); BRCA cis rs12135062 0.901 rs2651928 chr1:3101722 C/T cg00254258 chr1:3105189 PRDM16 -0.47 -11.0 -0.4 6.92e-26 Migraine; BRCA cis rs4566357 0.615 rs12618793 chr2:227909552 T/C cg11843606 chr2:227700838 RHBDD1 -0.42 -9.33 -0.35 1.73e-19 Coronary artery disease; BRCA cis rs10883723 0.962 rs1056738 chr10:104236481 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.42 0.57 6.53e-56 Allergic disease (asthma, hay fever or eczema); BRCA cis rs4481887 1.000 rs4244176 chr1:248468231 G/A cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA cis rs495337 0.720 rs6067271 chr20:48541663 G/A cg17835207 chr20:48524531 SPATA2 -0.69 -16.83 -0.55 6.92e-53 Psoriasis; BRCA cis rs7646881 1.000 rs7646987 chr3:158453442 A/G cg19483011 chr3:158453295 NA 0.47 9.0 0.34 2.65e-18 Tetralogy of Fallot; BRCA trans rs11098499 0.909 rs28668716 chr4:120309875 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.17 0.31 1.66e-15 Corneal astigmatism; BRCA cis rs9649213 0.593 rs1132971 chr7:97921533 A/G cg24562669 chr7:97807699 LMTK2 0.45 12.23 0.44 4.63e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs763014 1.000 rs2269558 chr16:682250 C/T cg08805041 chr16:621841 PIGQ -0.3 -8.01 -0.3 5.4e-15 Height; BRCA cis rs9487051 1.000 rs9480924 chr6:109617070 T/C cg12927641 chr6:109611667 NA -0.36 -8.97 -0.33 3.24e-18 Reticulocyte fraction of red cells; BRCA cis rs12701220 0.894 rs12539012 chr7:1052133 G/A cg02733842 chr7:1102375 C7orf50 -0.72 -12.45 -0.44 5.08e-32 Bronchopulmonary dysplasia; BRCA cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg08564027 chr20:61660810 NA 0.85 22.5 0.66 5.11e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg24562669 chr7:97807699 LMTK2 -0.43 -11.59 -0.42 2.49e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs2777491 0.957 rs8026197 chr15:41711447 C/T cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.24 -0.54 6.98e-50 Ulcerative colitis; BRCA cis rs873946 0.590 rs12259699 chr10:134549692 A/G cg18305652 chr10:134549665 INPP5A 0.51 13.24 0.46 1.52e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg26446133 chr18:72167187 CNDP2 -0.77 -18.89 -0.6 1.46e-63 Refractive error; BRCA cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg11814155 chr7:99998594 ZCWPW1 0.49 8.74 0.33 2.1e-17 Platelet count; BRCA cis rs1129187 0.755 rs9462855 chr6:42925936 G/C cg13397359 chr6:42928475 GNMT 0.68 16.23 0.54 7.73e-50 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs703842 1.000 rs10877019 chr12:58172929 A/G cg00677455 chr12:58241039 CTDSP2 -0.61 -13.8 -0.48 4.19e-38 Multiple sclerosis; BRCA cis rs10911232 0.507 rs4442336 chr1:182982538 T/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.68 0.55 3.88e-52 Hypertriglyceridemia; BRCA cis rs1008375 1.000 rs1558377 chr4:17650758 A/G cg15017067 chr4:17643749 FAM184B 0.32 9.86 0.36 1.96e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4722166 0.508 rs1474347 chr7:22768124 A/C cg26061582 chr7:22766209 IL6 -0.4 -9.37 -0.35 1.18e-19 Lung cancer; BRCA cis rs698833 0.532 rs698810 chr2:44703171 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.51 8.76 0.33 1.74e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs8005677 1.000 rs10148215 chr14:23382345 C/T cg01529538 chr14:23388837 RBM23 0.42 11.49 0.41 6.82e-28 Cognitive ability (multi-trait analysis); BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.28 -0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs12612619 0.732 rs1078809 chr2:27288915 C/T cg00617064 chr2:27272375 NA -0.32 -8.45 -0.32 2.02e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7914558 0.869 rs10883842 chr10:104941589 C/T cg04362960 chr10:104952993 NT5C2 0.42 10.19 0.37 1.04e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1506636 0.962 rs2456551 chr7:123394610 C/G cg03229431 chr7:123269106 ASB15 0.61 13.82 0.48 3.22e-38 Plateletcrit;Platelet count; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg18402987 chr7:1209562 NA 0.43 8.17 0.31 1.65e-15 Longevity;Endometriosis; BRCA cis rs10782582 0.609 rs2029680 chr1:76363505 A/C cg03433033 chr1:76189801 ACADM -0.39 -7.92 -0.3 1.08e-14 Daytime sleep phenotypes; BRCA cis rs2204008 0.774 rs11514062 chr12:38332297 A/C cg13010199 chr12:38710504 ALG10B 0.43 8.86 0.33 7.63e-18 Bladder cancer; BRCA cis rs6582630 0.537 rs12823925 chr12:38409323 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.12 0.56 2.19e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs13064411 0.735 rs10511326 chr3:113216325 T/C cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.55 9.3 0.35 2.11e-19 Renal function-related traits (BUN); BRCA cis rs12618769 0.625 rs4850878 chr2:99112180 T/A cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -15.0 -0.51 8.89e-44 Total cholesterol levels; BRCA cis rs7447593 0.626 rs3812036 chr5:176813404 C/T cg17509989 chr5:176798049 RGS14 0.77 13.95 0.48 8.82e-39 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs7666738 0.791 rs1559860 chr4:99024422 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs9325144 0.647 rs61930266 chr12:38922048 A/G cg23762105 chr12:34175262 ALG10 0.37 8.55 0.32 8.75e-17 Morning vs. evening chronotype; BRCA cis rs1707322 0.721 rs10890346 chr1:46223892 C/T cg03146154 chr1:46216737 IPP -0.53 -12.01 -0.43 4.03e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2180341 1.000 rs6569478 chr6:127598619 G/A cg27446573 chr6:127587934 RNF146 0.88 20.78 0.64 1.12e-73 Breast cancer; BRCA cis rs13095912 0.785 rs62291882 chr3:185313278 T/C cg11274856 chr3:185301563 NA 0.54 13.03 0.46 1.32e-34 Systolic blood pressure; BRCA cis rs6973256 0.834 rs10244670 chr7:133323417 A/G cg07491979 chr7:133331646 EXOC4 -0.38 -8.58 -0.32 7.07e-17 Intelligence (multi-trait analysis); BRCA cis rs7131987 0.903 rs1035604 chr12:29393102 G/A cg09582351 chr12:29534625 ERGIC2 -0.48 -11.67 -0.42 1.16e-28 QT interval; BRCA cis rs6951245 1.000 rs76804143 chr7:1082021 C/T cg03188948 chr7:1209495 NA 0.83 11.56 0.42 3.33e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs875971 0.825 rs1860472 chr7:66082723 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.85 -0.3 1.81e-14 Aortic root size; BRCA cis rs1008375 0.932 rs964012 chr4:17619184 A/G cg16339924 chr4:17578868 LAP3 0.68 16.51 0.55 2.83e-51 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3858526 0.584 rs10742809 chr11:5862532 G/T cg13902645 chr11:5959945 NA 0.42 9.22 0.34 4.21e-19 DNA methylation (variation); BRCA cis rs2276314 1.000 rs4799834 chr18:33566243 T/C cg05985134 chr18:33552581 C18orf21 0.66 12.77 0.45 1.94e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg07404485 chr7:94953653 PON1 -0.37 -8.34 -0.31 4.49e-16 Paraoxonase activity; BRCA trans rs2727020 0.521 rs937430 chr11:49542457 A/G cg03929089 chr4:120376271 NA 0.65 12.91 0.45 4.67e-34 Coronary artery disease; BRCA cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg26597838 chr10:835615 NA 1.07 17.87 0.58 3.23e-58 Eosinophil percentage of granulocytes; BRCA cis rs68170813 0.559 rs74925723 chr7:106954536 G/C cg02696742 chr7:106810147 HBP1 -0.54 -8.67 -0.32 3.66e-17 Coronary artery disease; BRCA cis rs7424096 0.613 rs72873859 chr2:37246738 T/G cg14987922 chr2:37194071 STRN 0.45 8.12 0.31 2.41e-15 High light scatter reticulocyte percentage of red cells; BRCA cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs6066835 1.000 rs742645 chr20:47323655 G/A cg18078177 chr20:47281410 PREX1 0.72 7.83 0.3 2.06e-14 Multiple myeloma; BRCA cis rs10870270 0.957 rs9971084 chr10:133788747 G/C cg17892150 chr10:133769511 PPP2R2D -0.72 -14.83 -0.51 5.56e-43 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2289583 0.642 rs11635266 chr15:75386649 T/C cg10253484 chr15:75165896 SCAMP2 0.39 8.01 0.3 5.32e-15 Systemic lupus erythematosus; BRCA cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg06618935 chr21:46677482 NA -0.35 -8.0 -0.3 5.93e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.788 rs35323494 chr21:46703739 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.39 0.35 1.02e-19 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs9325144 0.541 rs7303395 chr12:38664124 C/T cg23762105 chr12:34175262 ALG10 0.34 7.96 0.3 7.76e-15 Morning vs. evening chronotype; BRCA cis rs6952808 0.594 rs3778965 chr7:2138296 G/A cg02951883 chr7:2050386 MAD1L1 -0.54 -12.24 -0.44 4.41e-31 Bipolar disorder and schizophrenia; BRCA cis rs736408 0.509 rs2590838 chr3:52622086 G/A cg20224285 chr3:52813920 ITIH1 0.32 8.01 0.3 5.3e-15 Bipolar disorder; BRCA cis rs6912958 0.781 rs4334949 chr6:88290150 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.4 -0.32 2.93e-16 Monocyte percentage of white cells; BRCA cis rs735539 1.000 rs6490604 chr13:21284828 A/G cg04906043 chr13:21280425 IL17D -0.48 -10.82 -0.39 3.53e-25 Dental caries; BRCA cis rs12893668 0.543 rs1799796 chr14:104165927 T/C cg26031613 chr14:104095156 KLC1 -0.53 -9.49 -0.35 4.35e-20 Reticulocyte count; BRCA cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg15997130 chr1:24165203 NA -0.44 -10.03 -0.37 4.41e-22 Immature fraction of reticulocytes; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 10.13 0.37 1.9e-22 Gut microbiome composition (summer); BRCA cis rs1707322 0.721 rs10430124 chr1:46221617 C/T cg06784218 chr1:46089804 CCDC17 0.52 12.49 0.44 3.51e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs921968 0.510 rs591573 chr2:219478193 C/T cg10223061 chr2:219282414 VIL1 -0.28 -8.22 -0.31 1.11e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg11764359 chr7:65958608 NA 0.66 11.94 0.43 8.13e-30 Aortic root size; BRCA cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg09658497 chr7:2847517 GNA12 -0.4 -8.51 -0.32 1.27e-16 Height; BRCA trans rs12517041 1.000 rs995215 chr5:23285366 G/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs4819052 0.788 rs4819051 chr21:46693128 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6952808 0.743 rs4721097 chr7:1877503 G/T cg05279229 chr7:1896384 MAD1L1 -0.4 -7.87 -0.3 1.47e-14 Bipolar disorder and schizophrenia; BRCA cis rs425277 0.606 rs2257684 chr1:2077872 A/G cg24578937 chr1:2090814 PRKCZ 0.38 11.53 0.42 4.44e-28 Height; BRCA cis rs12367572 0.620 rs2731040 chr12:45416383 G/A cg04608330 chr12:45269318 NELL2 -0.4 -8.34 -0.31 4.75e-16 Gut microbiome composition (summer); BRCA cis rs1005277 0.541 rs2472177 chr10:38384015 T/G cg25427524 chr10:38739819 LOC399744 -0.71 -17.42 -0.57 6.9e-56 Extrinsic epigenetic age acceleration; BRCA cis rs17270561 0.636 rs7453371 chr6:25719256 A/G cg16482183 chr6:26056742 HIST1H1C 0.43 8.46 0.32 1.89e-16 Iron status biomarkers; BRCA cis rs910316 0.699 rs175039 chr14:75468950 G/C cg11812906 chr14:75593930 NEK9 -0.61 -14.13 -0.49 1.17e-39 Height; BRCA cis rs12477438 1.000 rs11897712 chr2:99735697 G/A cg08885076 chr2:99613938 TSGA10 -0.53 -9.59 -0.35 2.01e-20 Chronic sinus infection; BRCA trans rs11098499 0.863 rs7669520 chr4:120515278 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.15 0.31 1.85e-15 Corneal astigmatism; BRCA cis rs11190604 1.000 rs4919469 chr10:102298855 C/A cg07080220 chr10:102295463 HIF1AN 0.63 14.91 0.51 2.3e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg15017067 chr4:17643749 FAM184B 0.26 8.02 0.3 5.06e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12369635 0.929 rs3851667 chr12:129550552 G/T cg01909103 chr12:129572610 TMEM132D 0.61 7.81 0.3 2.31e-14 Schizophrenia (inflammation and infection response interaction); BRCA cis rs10791097 0.720 rs4936121 chr11:130733878 A/G cg12179176 chr11:130786555 SNX19 0.68 16.81 0.55 8.96e-53 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.58 12.28 0.44 2.89e-31 Age-related macular degeneration (geographic atrophy); BRCA cis rs10504229 1.000 rs61998259 chr8:58192290 T/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs7617773 0.674 rs13069029 chr3:48355024 A/G cg11946769 chr3:48343235 NME6 0.69 13.83 0.48 3e-38 Coronary artery disease; BRCA cis rs7654585 0.645 rs1123943 chr4:25924426 A/G cg10409131 chr4:25915609 C4orf52 -0.41 -8.58 -0.32 7.21e-17 Obesity-related traits; BRCA cis rs26949 0.526 rs1960479 chr5:60036215 T/G cg02684056 chr5:59996105 DEPDC1B -0.34 -7.91 -0.3 1.16e-14 Intelligence (multi-trait analysis); BRCA cis rs4481887 1.000 rs10888362 chr1:248483975 A/G cg13385794 chr1:248469461 NA -0.28 -7.83 -0.3 1.99e-14 Common traits (Other); BRCA cis rs9653442 0.777 rs6732141 chr2:100743492 G/C cg22139774 chr2:100720529 AFF3 -0.31 -8.67 -0.32 3.51e-17 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs597539 0.652 rs514833 chr11:68657734 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.25 0.59 3.36e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs9311474 0.581 rs4687626 chr3:52569098 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.31 9.94 0.37 9.5e-22 Electroencephalogram traits; BRCA trans rs35365539 1 rs35365539 chr3:49794347 A/AC cg21659725 chr3:3221576 CRBN -0.72 -22.05 -0.66 1.49e-80 Blood protein levels; BRCA cis rs708547 0.957 rs2458552 chr4:57773442 G/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 11.06 0.4 3.82e-26 Response to bleomycin (chromatid breaks); BRCA cis rs372883 0.648 rs2832297 chr21:30742996 A/C cg24692254 chr21:30365293 RNF160 0.47 10.39 0.38 1.82e-23 Pancreatic cancer; BRCA cis rs780096 0.546 rs1647284 chr2:27608115 C/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.31e-16 Total body bone mineral density; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg04944784 chr2:26401820 FAM59B 0.73 12.95 0.46 3.31e-34 Gut microbiome composition (summer); BRCA cis rs11690935 0.885 rs10202823 chr2:172780132 T/C cg13550731 chr2:172543902 DYNC1I2 -0.81 -23.56 -0.68 7.76e-89 Schizophrenia; BRCA cis rs9399137 0.507 rs6940258 chr6:135366132 C/T cg24558204 chr6:135376177 HBS1L 0.56 15.12 0.51 2.31e-44 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA trans rs61931739 0.534 rs1844526 chr12:34102780 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.23 0.34 3.94e-19 Morning vs. evening chronotype; BRCA cis rs11718455 1.000 rs17076273 chr3:44020113 A/G cg08738300 chr3:44038990 NA 0.46 8.96 0.33 3.56e-18 Coronary artery disease; BRCA trans rs9650657 0.585 rs4841401 chr8:10489592 C/G cg15556689 chr8:8085844 FLJ10661 -0.44 -10.37 -0.38 2.25e-23 Neuroticism; BRCA cis rs6752107 1.000 rs2289472 chr2:234182240 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.6 0.42 2.29e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7523050 0.908 rs17621644 chr1:109399023 C/T cg08274380 chr1:109419600 GPSM2 0.82 12.5 0.44 3.02e-32 Fat distribution (HIV); BRCA cis rs910316 0.934 rs4903278 chr14:75535019 C/A cg08847533 chr14:75593920 NEK9 0.91 23.74 0.68 8.08e-90 Height; BRCA trans rs853679 0.607 rs67101035 chr6:27798887 C/G cg06606381 chr12:133084897 FBRSL1 -0.88 -8.75 -0.33 1.87e-17 Depression; BRCA cis rs36051895 0.664 rs17425819 chr9:5114773 C/T cg02405213 chr9:5042618 JAK2 -0.44 -8.09 -0.3 2.93e-15 Pediatric autoimmune diseases; BRCA cis rs2180341 0.843 rs4895821 chr6:127572761 T/A cg24812749 chr6:127587940 RNF146 0.87 19.75 0.62 4.07e-68 Breast cancer; BRCA cis rs16858210 0.648 rs57604063 chr3:183578689 A/T cg25686905 chr3:183603175 PARL -0.39 -8.41 -0.32 2.7e-16 Menopause (age at onset); BRCA cis rs2404602 0.716 rs56216512 chr15:76686936 T/C cg23625390 chr15:77176239 SCAPER 0.39 9.15 0.34 7.86e-19 Blood metabolite levels; BRCA cis rs1552244 0.572 rs58862481 chr3:10164308 G/A cg00149659 chr3:10157352 C3orf10 1.1 18.64 0.59 2.97e-62 Alzheimer's disease; BRCA cis rs2576037 0.583 rs2187091 chr18:44520048 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.6 13.88 0.48 1.83e-38 Personality dimensions; BRCA cis rs7647973 0.516 rs4499638 chr3:49202782 C/G cg06212747 chr3:49208901 KLHDC8B 0.54 11.76 0.42 4.65e-29 Menarche (age at onset); BRCA cis rs2658782 0.724 rs2605626 chr11:93253903 A/G cg15737290 chr11:93063684 CCDC67 0.44 8.64 0.32 4.66e-17 Pulmonary function decline; BRCA cis rs1008375 0.932 rs11938710 chr4:17670664 G/C cg15017067 chr4:17643749 FAM184B -0.29 -8.76 -0.33 1.77e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs826838 0.967 rs826879 chr12:39088999 A/C cg13010199 chr12:38710504 ALG10B -0.43 -9.92 -0.37 1.1e-21 Heart rate; BRCA cis rs2730245 1.000 rs2527199 chr7:158737113 G/A cg14689365 chr7:158441557 NCAPG2 -0.43 -8.76 -0.33 1.8e-17 Height; BRCA cis rs2576037 1.000 rs2576037 chr18:44585420 C/T cg19077165 chr18:44547161 KATNAL2 0.39 8.32 0.31 5.33e-16 Personality dimensions; BRCA cis rs2370759 0.898 rs113412621 chr10:32579306 C/T cg01819863 chr10:32635814 EPC1 1.15 20.31 0.63 3.9e-71 Sexual dysfunction (female); BRCA cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg12573674 chr2:1569213 NA -0.51 -9.63 -0.36 1.38e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs67340775 0.748 rs13212651 chr6:27806985 A/G cg06606381 chr12:133084897 FBRSL1 -0.88 -8.75 -0.33 1.87e-17 Lung cancer in ever smokers; BRCA cis rs9815354 0.812 rs113144620 chr3:42008312 A/G cg03022575 chr3:42003672 ULK4 0.7 9.97 0.37 7.64e-22 Pulse pressure;Diastolic blood pressure; BRCA trans rs7746199 0.736 rs67652222 chr6:27586220 C/T cg01620082 chr3:125678407 NA -0.91 -10.25 -0.38 6.18e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA trans rs7618501 0.538 rs9856572 chr3:50109073 A/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.33 -9.14 -0.34 7.92e-19 Intelligence (multi-trait analysis); BRCA cis rs11252926 0.527 rs11252754 chr10:538637 G/A cg03684893 chr10:554711 DIP2C -0.43 -10.21 -0.37 8.8e-23 Psychosis in Alzheimer's disease; BRCA cis rs4555082 1.000 rs7146643 chr14:105757392 A/G cg06808227 chr14:105710500 BRF1 -0.69 -14.91 -0.51 2.35e-43 Mean platelet volume;Platelet distribution width; BRCA cis rs6570726 0.764 rs9399553 chr6:145873664 A/T cg23711669 chr6:146136114 FBXO30 0.8 18.91 0.6 1.14e-63 Lobe attachment (rater-scored or self-reported); BRCA cis rs796364 0.806 rs10445791 chr2:201078307 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.65 -9.2 -0.34 4.83e-19 Schizophrenia; BRCA cis rs2549003 0.870 rs61175929 chr5:131821548 C/G cg21138405 chr5:131827807 IRF1 0.4 12.93 0.46 3.89e-34 Asthma (sex interaction); BRCA cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg22105103 chr4:187893119 NA 0.33 10.72 0.39 8.67e-25 Lobe attachment (rater-scored or self-reported); BRCA trans rs9944715 0.911 rs8085138 chr18:43768751 G/A cg01718231 chr17:29326311 RNF135 -0.42 -8.72 -0.33 2.38e-17 Red cell distribution width;Mean corpuscular volume; BRCA cis rs6088590 0.931 rs6088624 chr20:33436852 T/A cg08999081 chr20:33150536 PIGU 0.35 8.95 0.33 3.94e-18 Coronary artery disease; BRCA cis rs7584330 0.780 rs7582828 chr2:238378476 A/C cg11271282 chr2:238384023 NA -0.41 -7.94 -0.3 9.44e-15 Prostate cancer; BRCA cis rs17253792 0.822 rs80328469 chr14:56067701 G/A cg01858014 chr14:56050164 KTN1 -0.74 -9.35 -0.35 1.43e-19 Putamen volume; BRCA cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg11584989 chr19:19387371 SF4 0.62 13.0 0.46 1.89e-34 Bipolar disorder; BRCA cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg02038168 chr22:39784481 NA -0.42 -8.66 -0.32 3.87e-17 Intelligence (multi-trait analysis); BRCA cis rs921968 0.565 rs6761437 chr2:219598092 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -11.04 -0.4 4.6e-26 Mean corpuscular hemoglobin concentration; BRCA trans rs931812 1.000 rs4734495 chr8:101917817 C/A cg20993868 chr7:22813445 NA 0.5 13.76 0.48 6.15e-38 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs6142102 0.580 rs4911139 chr20:32551535 G/A cg24642439 chr20:33292090 TP53INP2 0.4 8.05 0.3 4.2e-15 Skin pigmentation; BRCA cis rs3858526 0.523 rs10769289 chr11:5886607 C/T cg13902645 chr11:5959945 NA -0.47 -10.42 -0.38 1.42e-23 DNA methylation (variation); BRCA cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs12479064 0.694 rs11896520 chr2:99995517 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.58 -11.68 -0.42 1.1e-28 Chronic sinus infection; BRCA cis rs754466 0.580 rs1866437 chr10:79526766 A/G cg17075019 chr10:79541650 NA -0.82 -19.71 -0.61 6.7e-68 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2180341 0.824 rs9321076 chr6:127655614 G/A cg24812749 chr6:127587940 RNF146 0.88 20.66 0.63 4.91e-73 Breast cancer; BRCA cis rs2836974 0.644 rs1882779 chr21:40690938 T/C cg22974920 chr21:40686053 BRWD1 -0.41 -9.06 -0.34 1.56e-18 Cognitive function; BRCA cis rs2197308 0.565 rs4123923 chr12:37857684 T/C cg13010199 chr12:38710504 ALG10B 0.52 10.33 0.38 3.14e-23 Morning vs. evening chronotype; BRCA cis rs6951245 0.507 rs11763865 chr7:1194274 G/A cg04025307 chr7:1156635 C7orf50 0.42 8.28 0.31 7.16e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg26314531 chr2:26401878 FAM59B -0.67 -11.46 -0.41 8.59e-28 Gut microbiome composition (summer); BRCA trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg20587970 chr11:113659929 NA -1.24 -22.64 -0.67 8.57e-84 Hip circumference adjusted for BMI; BRCA cis rs651907 0.535 rs35810977 chr3:101531380 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 13.92 0.48 1.16e-38 Colorectal cancer; BRCA cis rs6831352 0.918 rs17218602 chr4:100061073 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.68 -0.36 8.73e-21 Alcohol dependence; BRCA cis rs9467711 0.591 rs3734528 chr6:26022244 A/G cg08501292 chr6:25962987 TRIM38 0.59 8.03 0.3 4.71e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg14820908 chr5:178986412 RUFY1 -0.5 -13.32 -0.47 6.58e-36 Lung cancer; BRCA cis rs4481887 1.000 rs10888360 chr1:248479282 G/A cg13385794 chr1:248469461 NA 0.28 7.97 0.3 7.1e-15 Common traits (Other); BRCA cis rs2839186 0.867 rs13050387 chr21:47701423 C/T cg12379764 chr21:47803548 PCNT -0.37 -8.05 -0.3 4.13e-15 Testicular germ cell tumor; BRCA cis rs7824557 0.614 rs2736286 chr8:11227104 A/G cg21775007 chr8:11205619 TDH -0.59 -13.01 -0.46 1.72e-34 Retinal vascular caliber; BRCA cis rs7267979 1.000 rs2474777 chr20:25272633 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.31 0.35 1.96e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs782590 0.608 rs10207590 chr2:55921782 G/C cg18811423 chr2:55921094 PNPT1 -0.65 -19.98 -0.62 2.26e-69 Metabolic syndrome; BRCA cis rs7903847 0.642 rs4635018 chr10:99137839 C/G cg08345082 chr10:99160200 RRP12 0.3 8.86 0.33 7.78e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.47 -0.32 1.65e-16 Total body bone mineral density; BRCA cis rs921968 0.521 rs56923478 chr2:219638539 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.02 -0.4 5.7e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs73242632 0.881 rs10034395 chr4:57863131 G/A cg20415529 chr4:57845134 POLR2B;C4orf14 0.67 8.0 0.3 6.05e-15 Congenital heart disease (maternal effect); BRCA cis rs7917772 0.582 rs10883736 chr10:104320029 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.44 0.5 4.02e-41 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6952808 0.723 rs60995052 chr7:2030007 G/C cg18279126 chr7:2041391 MAD1L1 0.37 8.21 0.31 1.22e-15 Bipolar disorder and schizophrenia; BRCA cis rs796364 1.000 rs1704186 chr2:200769539 A/C cg23649088 chr2:200775458 C2orf69 0.6 8.92 0.33 4.89e-18 Schizophrenia; BRCA cis rs2526882 0.541 rs2526859 chr14:71412207 C/T cg15816911 chr14:71606274 NA -0.38 -8.46 -0.32 1.8e-16 Schizophrenia; BRCA cis rs1971762 0.583 rs1527068 chr12:54088688 A/G cg23533419 chr12:54090519 NA -0.33 -8.39 -0.31 3.22e-16 Height; BRCA cis rs4478858 0.684 rs7549245 chr1:31752187 A/G cg00250761 chr1:31883323 NA -0.31 -8.17 -0.31 1.63e-15 Alcohol dependence; BRCA cis rs1401999 1.000 rs6767013 chr3:183680102 G/A cg01324343 chr3:183735012 ABCC5 0.83 20.88 0.64 3.3e-74 Anterior chamber depth; BRCA cis rs9462027 0.628 rs2814971 chr6:34714209 A/T cg07306190 chr6:34760872 UHRF1BP1 0.26 8.06 0.3 3.79e-15 Systemic lupus erythematosus; BRCA cis rs6484504 0.512 rs2761594 chr11:31318244 A/G cg26647111 chr11:31128758 NA 0.45 9.79 0.36 3.41e-21 Red blood cell count; BRCA cis rs514406 0.505 rs269290 chr1:53167027 A/T cg16325326 chr1:53192061 ZYG11B 0.86 25.3 0.71 2.2e-98 Monocyte count; BRCA cis rs10504229 0.683 rs16921823 chr8:58108612 G/C cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA cis rs7927592 0.913 rs7925275 chr11:68290433 T/C cg20283391 chr11:68216788 NA -0.49 -9.58 -0.35 2.18e-20 Total body bone mineral density; BRCA cis rs3820928 0.933 rs1429267 chr2:227767593 G/C cg11843606 chr2:227700838 RHBDD1 -0.39 -8.63 -0.32 4.82e-17 Pulmonary function; BRCA cis rs9393692 0.875 rs12526215 chr6:26262916 T/C cg05868516 chr6:26286170 HIST1H4H 0.51 11.2 0.41 1.04e-26 Educational attainment; BRCA cis rs9487051 1.000 rs7748918 chr6:109613564 A/G cg21918786 chr6:109611834 NA -0.43 -11.52 -0.41 5.1e-28 Reticulocyte fraction of red cells; BRCA cis rs2070488 0.804 rs13094715 chr3:38504430 G/A cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.87 0.58 3.21e-58 Electrocardiographic conduction measures; BRCA cis rs514406 0.644 rs7552663 chr1:53204352 C/T cg25767906 chr1:53392781 SCP2 0.34 7.88 0.3 1.42e-14 Monocyte count; BRCA cis rs61008539 0.815 rs6960062 chr7:884665 A/G cg00934597 chr7:893267 UNC84A -0.42 -8.92 -0.33 5.06e-18 Perceived unattractiveness to mosquitoes; BRCA cis rs12410462 0.901 rs1120000 chr1:227659615 T/C cg04117972 chr1:227635322 NA 0.45 8.14 0.31 2.02e-15 Major depressive disorder; BRCA cis rs2479724 0.792 rs7739064 chr6:41834037 C/A cg17623882 chr6:41773611 USP49 -0.36 -9.71 -0.36 7.09e-21 Menarche (age at onset); BRCA cis rs7666738 0.830 rs11935588 chr4:98979862 A/G cg17366294 chr4:99064904 C4orf37 -0.45 -10.68 -0.39 1.31e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6743226 0.934 rs7604465 chr2:242249828 C/T cg10021735 chr2:242295487 FARP2 0.36 10.14 0.37 1.66e-22 Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI in non-smokers; BRCA cis rs10927875 0.541 rs1739842 chr1:16342848 T/G cg22431228 chr1:16359049 CLCNKA -0.44 -9.81 -0.36 2.97e-21 Dilated cardiomyopathy; BRCA cis rs887829 0.570 rs13015720 chr2:234600999 G/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.48 -0.32 1.53e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs13108904 0.905 rs1680074 chr4:1279621 G/A cg05665937 chr4:1216051 CTBP1 -0.39 -8.44 -0.32 2.2e-16 Obesity-related traits; BRCA cis rs10540 1.000 rs35898083 chr11:484469 C/T cg19913688 chr11:428466 ANO9 -0.71 -10.01 -0.37 5.02e-22 Body mass index; BRCA cis rs875971 0.862 rs1612452 chr7:65573896 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.01 -0.3 5.35e-15 Aortic root size; BRCA cis rs9443645 0.868 rs9443643 chr6:79798838 A/G cg11833968 chr6:79620685 NA -0.45 -10.12 -0.37 1.92e-22 Intelligence (multi-trait analysis); BRCA trans rs208520 0.690 rs864314 chr6:66814830 G/T cg08225398 chr13:45563328 KIAA1704;NUFIP1 0.79 9.95 0.37 8.65e-22 Exhaled nitric oxide output; BRCA trans rs7618501 0.603 rs72942333 chr3:49986118 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.44 0.35 6.71e-20 Intelligence (multi-trait analysis); BRCA cis rs1580019 0.587 rs7806941 chr7:32553319 G/T cg06627557 chr7:32535165 LSM5;AVL9 1.05 29.38 0.76 1.06e-120 Cognitive ability; BRCA cis rs2019137 0.936 rs4849169 chr2:113953657 A/C cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.58 -0.39 3.38e-24 Lymphocyte counts; BRCA cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg05283184 chr6:79620031 NA -0.41 -10.51 -0.38 6.16e-24 Intelligence (multi-trait analysis); BRCA cis rs13136331 0.718 rs2627690 chr4:88653616 A/G cg22416721 chr4:88570574 DMP1 -0.49 -12.17 -0.43 8.6e-31 Sitting height ratio; BRCA cis rs7184046 0.797 rs13737 chr15:75932129 G/T cg20655648 chr15:75932815 IMP3 0.51 9.92 0.37 1.09e-21 Height; BRCA cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg15017067 chr4:17643749 FAM184B 0.32 9.86 0.36 1.96e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.534 rs2389276 chr12:34097891 T/C cg13010199 chr12:38710504 ALG10B 0.4 8.1 0.31 2.77e-15 Morning vs. evening chronotype; BRCA cis rs2075371 0.796 rs1643040 chr7:134011703 G/C cg02659138 chr7:134003124 SLC35B4 0.33 10.4 0.38 1.67e-23 Mean platelet volume; BRCA trans rs11098499 0.863 rs1383533 chr4:120434576 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.16 0.31 1.81e-15 Corneal astigmatism; BRCA cis rs798554 0.634 rs1182180 chr7:2873279 G/T cg18446336 chr7:2847575 GNA12 -0.33 -7.93 -0.3 9.94e-15 Height; BRCA cis rs1008375 0.966 rs6832962 chr4:17652133 T/C cg04450456 chr4:17643702 FAM184B 0.36 9.77 0.36 4.16e-21 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3858526 0.584 rs10769271 chr11:5860572 T/C cg13902645 chr11:5959945 NA -0.47 -10.09 -0.37 2.5e-22 DNA methylation (variation); BRCA cis rs3858526 0.584 rs10734559 chr11:5861788 A/C cg13902645 chr11:5959945 NA -0.46 -9.94 -0.37 9.75e-22 DNA methylation (variation); BRCA cis rs9733 0.525 rs11584184 chr1:150695689 A/T cg18016565 chr1:150552671 MCL1 0.34 8.05 0.3 4.08e-15 Tonsillectomy; BRCA cis rs9381040 0.655 rs6939989 chr6:41020205 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -9.06 -0.34 1.6e-18 Alzheimer's disease (late onset); BRCA cis rs3008870 1.000 rs2182143 chr1:67378936 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.49 0.65 1.55e-77 Lymphocyte percentage of white cells; BRCA cis rs13046373 0.535 rs1395778 chr21:31985502 G/C cg16431978 chr21:31797932 KRTAP13-3 0.35 8.76 0.33 1.7e-17 HDL cholesterol; BRCA cis rs2033711 0.870 rs4801270 chr19:58932762 C/A cg00825309 chr19:58991885 ZNF446 -0.59 -12.77 -0.45 1.95e-33 Uric acid clearance; BRCA cis rs28374715 0.532 rs316607 chr15:41772693 G/A cg18705301 chr15:41695430 NDUFAF1 -1.08 -24.92 -0.7 2.91e-96 Ulcerative colitis; BRCA cis rs9796 0.621 rs9972349 chr15:41491656 A/G cg18705301 chr15:41695430 NDUFAF1 -0.37 -7.84 -0.3 1.92e-14 Menopause (age at onset); BRCA cis rs6066835 1.000 rs6066832 chr20:47354132 C/A cg18078177 chr20:47281410 PREX1 0.69 8.6 0.32 6.2e-17 Multiple myeloma; BRCA cis rs17376456 0.877 rs12153788 chr5:93405437 A/G cg25358565 chr5:93447407 FAM172A 1.2 18.7 0.59 1.46e-62 Diabetic retinopathy; BRCA cis rs1348850 0.837 rs4243388 chr2:178284604 T/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 9.35 0.35 1.45e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs2882667 0.690 rs12186373 chr5:138248574 T/A cg04439458 chr5:138467593 SIL1 -0.34 -8.36 -0.31 4.05e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg00149659 chr3:10157352 C3orf10 0.8 14.11 0.49 1.53e-39 Alzheimer's disease; BRCA cis rs7647973 0.710 rs1491983 chr3:49639803 G/T cg03060546 chr3:49711283 APEH 0.55 9.22 0.34 4.32e-19 Menarche (age at onset); BRCA cis rs7666738 0.830 rs9995370 chr4:98732145 T/G cg05340658 chr4:99064831 C4orf37 0.63 15.15 0.51 1.51e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs2070488 0.965 rs7373828 chr3:38524311 A/G cg24069376 chr3:38537580 EXOG 0.39 11.26 0.41 6.04e-27 Electrocardiographic conduction measures; BRCA cis rs6964587 0.933 rs6465350 chr7:91768615 G/A cg01689657 chr7:91764605 CYP51A1 0.24 8.86 0.33 7.58e-18 Breast cancer; BRCA cis rs11167764 1.000 rs10057309 chr5:141479870 T/C cg08523384 chr5:141488047 NDFIP1 -0.42 -9.68 -0.36 9.11e-21 Crohn's disease; BRCA cis rs1707322 1.000 rs4660335 chr1:46474718 C/T cg03146154 chr1:46216737 IPP 0.49 10.62 0.39 2.27e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs57221529 0.709 rs72703034 chr5:577101 C/T cg08313168 chr12:7315531 NA 0.5 8.09 0.3 2.95e-15 Lung disease severity in cystic fibrosis; BRCA cis rs12701220 0.901 rs12701708 chr7:1090333 C/T cg06145435 chr7:1022769 CYP2W1 0.44 8.39 0.32 3.08e-16 Bronchopulmonary dysplasia; BRCA cis rs7833790 1.000 rs7833790 chr8:82731157 T/C cg27398817 chr8:82754497 SNX16 -0.42 -8.68 -0.32 3.2e-17 Diastolic blood pressure; BRCA cis rs57590327 0.508 rs9820349 chr3:81958587 A/G cg07356753 chr3:81810745 GBE1 -0.37 -8.73 -0.33 2.26e-17 Extraversion; BRCA cis rs72928364 0.860 rs13081830 chr3:100791262 G/A cg10123952 chr3:100791384 NA 0.59 8.45 0.32 1.97e-16 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs6724607 1.000 rs10165399 chr2:191441595 A/G cg11845111 chr2:191398756 TMEM194B 0.41 9.23 0.34 4.02e-19 Pulse pressure; BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg01262667 chr19:19385393 TM6SF2 0.41 10.56 0.39 3.79e-24 Tonsillectomy; BRCA cis rs3858526 0.917 rs10769386 chr11:5973420 C/T cg05234568 chr11:5960015 NA 0.47 9.19 0.34 5.45e-19 DNA methylation (variation); BRCA cis rs4727027 0.870 rs1568945 chr7:148874112 T/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 8.9 0.33 5.51e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs3857067 0.506 rs282450 chr4:95139598 G/C cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.04 -0.37 3.99e-22 QT interval; BRCA cis rs7523273 0.627 rs2724389 chr1:207933648 T/C cg22525895 chr1:207977042 MIR29B2 0.47 12.05 0.43 2.91e-30 Schizophrenia; BRCA cis rs507080 0.922 rs625513 chr11:118555719 A/C cg09144398 chr11:118550485 TREH -0.38 -9.05 -0.34 1.69e-18 Serum metabolite levels; BRCA cis rs6121246 0.909 rs6060923 chr20:30336655 A/C cg13852791 chr20:30311386 BCL2L1 0.84 16.5 0.55 3.24e-51 Mean corpuscular hemoglobin; BRCA cis rs7829975 0.688 rs6601703 chr8:8380224 A/G cg08975724 chr8:8085496 FLJ10661 0.5 10.69 0.39 1.2e-24 Mood instability; BRCA cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.26 0.49 3.04e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs477895 0.629 rs7130030 chr11:63933733 T/G cg04317338 chr11:64019027 PLCB3 0.56 9.69 0.36 7.93e-21 Mean platelet volume; BRCA cis rs2386661 0.712 rs11259544 chr10:5646708 T/C cg17085576 chr10:5658249 NA -0.33 -8.18 -0.31 1.57e-15 Breast cancer; BRCA cis rs4713118 0.955 rs9368528 chr6:27683798 G/A cg20933634 chr6:27740509 NA 0.44 8.43 0.32 2.27e-16 Parkinson's disease; BRCA cis rs11874712 0.965 rs12954944 chr18:43664115 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.91 0.4 1.61e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs35110281 0.776 rs9983763 chr21:44990578 A/G cg21573476 chr21:45109991 RRP1B 0.42 10.39 0.38 1.76e-23 Mean corpuscular volume; BRCA cis rs10463316 0.894 rs6579866 chr5:150762524 A/G cg03212797 chr5:150827313 SLC36A1 -0.42 -8.22 -0.31 1.12e-15 Metabolite levels (Pyroglutamine); BRCA cis rs11690935 0.851 rs10174055 chr2:172858214 C/T cg13550731 chr2:172543902 DYNC1I2 -0.8 -23.34 -0.68 1.37e-87 Schizophrenia; BRCA cis rs832540 0.519 rs6450411 chr5:56265771 A/G cg24531977 chr5:56204891 C5orf35 -0.43 -8.66 -0.32 3.83e-17 Coronary artery disease; BRCA cis rs12971120 0.891 rs11151960 chr18:72177232 G/A cg26446133 chr18:72167187 CNDP2 -0.74 -13.01 -0.46 1.79e-34 Refractive error; BRCA trans rs8073060 0.544 rs8071584 chr17:33999435 G/A cg19694781 chr19:47549865 TMEM160 -1.04 -21.49 -0.65 1.61e-77 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA trans rs28735056 0.565 rs12957336 chr18:77716889 A/G cg05926928 chr17:57297772 GDPD1 -0.42 -8.41 -0.32 2.64e-16 Schizophrenia; BRCA cis rs11577318 0.853 rs12743998 chr1:26629882 G/A cg00852783 chr1:26633632 UBXN11 0.51 11.0 0.4 6.85e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs7666738 0.830 rs7657982 chr4:99044015 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.3 0.31 6.28e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs8017423 0.647 rs12589952 chr14:90821364 T/C cg04374321 chr14:90722782 PSMC1 -0.49 -12.06 -0.43 2.51e-30 Mortality in heart failure; BRCA cis rs6951245 0.935 rs112554101 chr7:1065535 A/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.7 -12.54 -0.44 2.03e-32 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1005277 0.522 rs289647 chr10:37968278 A/G cg00409905 chr10:38381863 ZNF37A -0.48 -10.13 -0.37 1.79e-22 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 0.572 rs67439440 chr3:10169503 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -9.11 -0.34 1.06e-18 Alzheimer's disease; BRCA cis rs2712184 0.652 rs13000985 chr2:217644361 T/G cg05032264 chr2:217675019 NA 0.34 7.98 0.3 6.68e-15 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs9287719 0.600 rs10197187 chr2:10726639 A/T cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs9486719 0.690 rs2092094 chr6:96844123 G/C cg06623918 chr6:96969491 KIAA0776 0.74 12.19 0.43 6.85e-31 Migraine;Coronary artery disease; BRCA cis rs7264396 0.836 rs41293080 chr20:34187697 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.57 -12.15 -0.43 1.06e-30 Total cholesterol levels; BRCA cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg16414030 chr3:133502952 NA -0.48 -11.1 -0.4 2.56e-26 Iron status biomarkers; BRCA cis rs17092148 0.887 rs2295443 chr20:33173827 T/C cg16810054 chr20:33298113 TP53INP2 -0.47 -10.67 -0.39 1.46e-24 Neuroticism; BRCA cis rs2882667 0.858 rs2043271 chr5:138459108 A/G cg04439458 chr5:138467593 SIL1 -0.41 -10.51 -0.38 6.16e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs921968 0.541 rs636723 chr2:219373197 A/G cg02176678 chr2:219576539 TTLL4 0.45 11.73 0.42 6.24e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs2464469 0.526 rs2899612 chr15:58335867 G/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.93 -0.37 1.09e-21 Barrett's esophagus or Esophageal adenocarcinoma; BRCA cis rs12477438 0.765 rs7605734 chr2:99644068 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.73 -0.42 6.2e-29 Chronic sinus infection; BRCA cis rs965469 0.779 rs6037516 chr20:3233142 C/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.68 -0.32 3.38e-17 IFN-related cytopenia; BRCA cis rs35110281 0.743 rs2329443 chr21:45059431 C/T cg01579765 chr21:45077557 HSF2BP -0.43 -10.91 -0.4 1.63e-25 Mean corpuscular volume; BRCA cis rs7613875 0.641 rs6793528 chr3:50100188 C/A cg05623727 chr3:50126028 RBM5 -0.49 -12.16 -0.43 9.5e-31 Body mass index; BRCA cis rs4076764 1.000 rs4076764 chr1:163441286 A/G cg24596788 chr1:163392923 NA -0.37 -9.91 -0.36 1.25e-21 Motion sickness; BRCA trans rs7618501 0.966 rs7372966 chr3:49788969 T/C cg21659725 chr3:3221576 CRBN -0.72 -21.74 -0.65 6.94e-79 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs7667796 chr4:99071415 G/T cg03676636 chr4:99064102 C4orf37 -0.2 -7.9 -0.3 1.26e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10911232 0.507 rs4422969 chr1:183020762 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.75 0.55 1.76e-52 Hypertriglyceridemia; BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg12444411 chr7:2802554 GNA12 -0.36 -9.1 -0.34 1.11e-18 Height; BRCA cis rs1707322 0.691 rs61784799 chr1:46177748 A/G cg03146154 chr1:46216737 IPP -0.53 -11.86 -0.42 1.87e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs8062405 1.000 rs3888190 chr16:28889486 C/A cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 4.85e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs17270561 0.608 rs9358875 chr6:25738008 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.82 0.33 1.04e-17 Iron status biomarkers; BRCA cis rs1801251 1.000 rs283484 chr2:233646505 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.35 0.41 2.4200000000000002e-27 Coronary artery disease; BRCA cis rs8017423 0.647 rs12883000 chr14:90820557 G/A cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg04166393 chr7:2884313 GNA12 0.48 9.23 0.34 3.97e-19 Height; BRCA cis rs10782582 0.593 rs11164042 chr1:76178440 G/A cg03433033 chr1:76189801 ACADM -0.47 -9.83 -0.36 2.43e-21 Daytime sleep phenotypes; BRCA trans rs4689592 0.513 rs4689586 chr4:7067413 A/G cg07817883 chr1:32538562 TMEM39B -0.44 -8.57 -0.32 7.59e-17 Monocyte percentage of white cells; BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg14062083 chr21:31802829 KRTAP13-4 0.35 9.59 0.35 1.86e-20 HDL cholesterol; BRCA trans rs61931739 0.534 rs1844526 chr12:34102780 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.16 0.49 8.91e-40 Morning vs. evening chronotype; BRCA cis rs7493 0.755 rs740264 chr7:95021803 T/G cg17330251 chr7:94953956 PON1 -0.42 -8.78 -0.33 1.45e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7072216 0.763 rs12763326 chr10:100167396 A/G cg26618903 chr10:100175079 PYROXD2 0.3 8.85 0.33 8.39e-18 Metabolite levels; BRCA cis rs2204008 0.653 rs11182569 chr12:38572452 G/A cg26384229 chr12:38710491 ALG10B 0.78 18.11 0.58 1.71e-59 Bladder cancer; BRCA cis rs262150 0.630 rs2730274 chr7:158796062 C/A cg19418458 chr7:158789849 NA -0.45 -10.01 -0.37 5.16e-22 Facial morphology (factor 20); BRCA cis rs514406 0.668 rs1672911 chr1:53340320 T/C cg16325326 chr1:53192061 ZYG11B 0.58 12.58 0.45 1.42e-32 Monocyte count; BRCA cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg08109568 chr15:31115862 NA -0.45 -10.67 -0.39 1.45e-24 Huntington's disease progression; BRCA trans rs2270927 1.000 rs13174383 chr5:75580416 T/G cg13563193 chr19:33072644 PDCD5 0.86 11.76 0.42 4.72e-29 Mean corpuscular volume; BRCA trans rs7618501 1.000 rs695238 chr3:49869158 A/C cg21659725 chr3:3221576 CRBN 0.72 22.39 0.66 1.95e-82 Intelligence (multi-trait analysis); BRCA cis rs7524258 0.900 rs1476047 chr1:7312172 C/T cg07173049 chr1:7289937 CAMTA1 0.42 10.86 0.39 2.58e-25 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs4727027 0.704 rs12537763 chr7:148903984 G/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.39 8.11 0.31 2.52e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs826838 1.000 rs826838 chr12:39106731 C/T cg13010199 chr12:38710504 ALG10B -0.43 -9.93 -0.37 1.07e-21 Heart rate; BRCA cis rs698833 0.926 rs1067353 chr2:44666626 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 11.05 0.4 4.35e-26 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs709400 0.633 rs10143247 chr14:103920927 G/A cg12935359 chr14:103987150 CKB -0.59 -14.08 -0.49 2.04e-39 Body mass index; BRCA cis rs12477438 0.520 rs10865029 chr2:99718298 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.59e-84 Chronic sinus infection; BRCA cis rs2842992 0.789 rs4709376 chr6:160226337 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.71 17.67 0.57 3.55e-57 Age-related macular degeneration (geographic atrophy); BRCA cis rs4910157 1 rs4910157 chr11:8941215 A/G cg12365402 chr11:9010492 NRIP3 0.43 9.65 0.36 1.21e-20 Tonsillectomy; BRCA cis rs9814567 1.000 rs7429866 chr3:134236306 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.3 0.31 6.36e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.639 rs35527749 chr8:58128077 G/T cg22535103 chr8:58192502 C8orf71 -0.53 -9.03 -0.34 1.93e-18 Developmental language disorder (linguistic errors); BRCA cis rs7584330 0.657 rs10202599 chr2:238352465 A/C cg14458575 chr2:238380390 NA 0.57 12.87 0.45 7.3e-34 Prostate cancer; BRCA cis rs2153535 0.580 rs1932283 chr6:8477661 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.54e-23 Motion sickness; BRCA cis rs7772486 0.720 rs1890171 chr6:146072114 T/C cg13319975 chr6:146136371 FBXO30 0.43 10.01 0.37 5.33e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs8180040 0.764 rs4682852 chr3:47177772 C/T cg16586182 chr3:47516702 SCAP -0.55 -12.8 -0.45 1.49e-33 Colorectal cancer; BRCA cis rs11920090 0.860 rs7643425 chr3:170737395 A/G cg09710316 chr3:170744871 SLC2A2 0.48 8.84 0.33 9.14e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs763014 0.966 rs4984677 chr16:671682 A/G cg07256732 chr16:621771 PIGQ -0.35 -9.31 -0.35 1.97e-19 Height; BRCA cis rs7552404 0.921 rs10873685 chr1:76218818 A/C cg22875332 chr1:76189707 ACADM 0.69 14.66 0.5 3.54e-42 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs11098499 0.730 rs12505735 chr4:120532956 G/T cg25214090 chr10:38739885 LOC399744 0.51 11.16 0.4 1.56e-26 Corneal astigmatism; BRCA cis rs7267979 1.000 rs6050590 chr20:25384994 G/A cg08601574 chr20:25228251 PYGB -0.34 -8.19 -0.31 1.4e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs853679 0.546 rs200954 chr6:27838764 C/G cg26587870 chr6:27730563 NA -0.55 -8.23 -0.31 1.05e-15 Depression; BRCA cis rs6500602 0.682 rs3761679 chr16:4457907 C/G cg08645402 chr16:4508243 NA 0.36 7.82 0.3 2.13e-14 Schizophrenia; BRCA cis rs7071206 0.947 rs1877998 chr10:79411740 C/T cg07817648 chr10:79422355 NA -0.68 -12.48 -0.44 3.74e-32 Bone mineral density; BRCA cis rs701145 0.529 rs355746 chr3:153961627 C/G cg12800244 chr3:153838788 SGEF 0.45 8.92 0.33 4.82e-18 Coronary artery disease; BRCA cis rs11190604 1.000 rs11190541 chr10:102203071 A/G cg07080220 chr10:102295463 HIF1AN 0.49 11.24 0.41 7.04e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs11583043 0.918 rs3850453 chr1:101408933 T/C cg16556008 chr1:101360663 SLC30A7;EXTL2 0.44 9.82 0.36 2.62e-21 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg08470875 chr2:26401718 FAM59B -0.51 -8.3 -0.31 6.38e-16 Gut microbiome composition (summer); BRCA trans rs56176327 0.600 rs7628207 chr3:49754970 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.41 -8.49 -0.32 1.4e-16 Intelligence (multi-trait analysis); BRCA cis rs2836974 0.584 rs34436313 chr21:40685246 A/G cg06238570 chr21:40685208 BRWD1 -0.45 -8.8 -0.33 1.24e-17 Cognitive function; BRCA cis rs10504229 1.000 rs9650139 chr8:58190508 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.41 -0.44 8.14e-32 Developmental language disorder (linguistic errors); BRCA cis rs8062405 0.964 rs11860513 chr16:28825420 C/T cg16576597 chr16:28551801 NUPR1 0.29 8.21 0.31 1.24e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -11.49 -0.41 6.65e-28 Personality dimensions; BRCA cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg18963800 chr10:38644991 HSD17B7P2 -0.4 -7.91 -0.3 1.12e-14 Extrinsic epigenetic age acceleration; BRCA cis rs6582630 0.537 rs8189533 chr12:38391068 A/G cg13010199 chr12:38710504 ALG10B 0.51 9.94 0.37 9.79e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7119 0.717 rs11629835 chr15:77787469 G/T cg17802220 chr15:77601643 NA -0.47 -10.43 -0.38 1.24e-23 Type 2 diabetes; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg22920501 chr2:26401640 FAM59B -0.94 -15.9 -0.53 3.19e-48 Gut microbiome composition (summer); BRCA cis rs6745190 0.575 rs7580796 chr2:181977769 T/C cg00481216 chr2:181971175 NA 0.4 9.45 0.35 6.15e-20 White blood cell count; BRCA cis rs9831754 0.704 rs1512492 chr3:78471190 A/C cg06138941 chr3:78371609 NA -0.51 -11.45 -0.41 9.46e-28 Calcium levels; BRCA cis rs877282 1.000 rs2004479 chr10:770854 G/A cg17470449 chr10:769945 NA 0.52 9.51 0.35 3.85e-20 Uric acid levels; BRCA cis rs12612619 0.704 rs10185736 chr2:27321224 T/C cg00617064 chr2:27272375 NA 0.33 8.27 0.31 7.6e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs6450176 0.909 rs255755 chr5:53307772 A/G ch.5.1024479R chr5:53302184 ARL15 -0.6 -14.46 -0.5 3.51e-41 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs7091068 0.536 rs7893369 chr10:95410147 A/G cg20715218 chr10:95462985 C10orf4 0.58 10.65 0.39 1.75e-24 Urinary tract infection frequency; BRCA cis rs6062302 0.522 rs6090476 chr20:62248001 G/A cg16989086 chr20:62203971 PRIC285 0.52 8.77 0.33 1.63e-17 Glioblastoma; BRCA cis rs6723226 0.699 rs805830 chr2:32501475 T/C cg02381751 chr2:32503542 YIPF4 0.64 13.23 0.46 1.79e-35 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg00814883 chr7:100076585 TSC22D4 -0.48 -10.72 -0.39 9.02e-25 Platelet count; BRCA cis rs6121246 0.909 rs3203770 chr20:30382315 A/G cg21427119 chr20:30132790 HM13 -0.42 -8.89 -0.33 6.37e-18 Mean corpuscular hemoglobin; BRCA cis rs1707322 0.686 rs2991977 chr1:46053683 G/A cg03146154 chr1:46216737 IPP -0.49 -10.73 -0.39 8.52e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7639513 0.591 rs9849171 chr3:12622623 G/C cg23032965 chr3:12705835 RAF1 0.65 14.07 0.49 2.35e-39 Itch intensity from mosquito bite; BRCA cis rs400736 0.860 rs371452 chr1:8084051 C/T cg25007680 chr1:8021821 PARK7 0.47 11.7 0.42 8.38e-29 Response to antidepressants and depression; BRCA cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg13334819 chr7:99746414 C7orf59 -0.35 -7.93 -0.3 9.57e-15 Coronary artery disease; BRCA cis rs35306767 1.000 rs35306767 chr10:989437 A/T cg26597838 chr10:835615 NA 1.03 17.3 0.56 2.73e-55 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs35938349 chr4:98974998 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs847577 0.715 rs12665986 chr7:97719676 A/G cg24562669 chr7:97807699 LMTK2 -0.51 -14.12 -0.49 1.35e-39 Breast cancer; BRCA cis rs7772486 0.686 rs1011596 chr6:146076433 A/G cg23711669 chr6:146136114 FBXO30 0.72 17.39 0.57 9.73e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs1997103 1.000 rs6973450 chr7:55396537 A/G cg17469321 chr7:55412551 NA 0.51 9.71 0.36 6.72e-21 QRS interval (sulfonylurea treatment interaction); BRCA trans rs9393777 0.920 rs13207689 chr6:27369704 C/G cg01620082 chr3:125678407 NA -0.85 -10.31 -0.38 3.56e-23 Intelligence (multi-trait analysis); BRCA trans rs3960554 0.610 rs11971800 chr7:75731608 C/T cg19862616 chr7:65841803 NCRNA00174 0.57 12.15 0.43 1.03e-30 Eotaxin levels; BRCA cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg20891558 chr2:74357851 NA 0.51 12.41 0.44 7.62e-32 Gestational age at birth (maternal effect); BRCA cis rs7618501 0.665 rs7621352 chr3:50070763 A/C cg05623727 chr3:50126028 RBM5 -0.42 -9.97 -0.37 7.66e-22 Intelligence (multi-trait analysis); BRCA cis rs28735056 0.903 rs56185453 chr18:77638297 A/G cg20368463 chr18:77673604 PQLC1 -0.42 -10.73 -0.39 7.91e-25 Schizophrenia; BRCA cis rs9393692 0.846 rs9366651 chr6:26336696 G/T cg05868516 chr6:26286170 HIST1H4H 0.51 11.27 0.41 5.38e-27 Educational attainment; BRCA cis rs4319547 0.695 rs113841747 chr12:122886088 G/T cg05707623 chr12:122985044 ZCCHC8 0.5 9.68 0.36 9.36e-21 Body mass index; BRCA cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg13798912 chr7:905769 UNC84A -0.49 -7.82 -0.3 2.25e-14 Cerebrospinal P-tau181p levels; BRCA cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg24130564 chr14:104152367 KLC1 -0.4 -9.03 -0.34 2.03e-18 Intelligence (multi-trait analysis); BRCA trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -10.0 -0.37 5.53e-22 Neuroticism; BRCA cis rs703842 0.964 rs10431552 chr12:58178148 G/A cg00677455 chr12:58241039 CTDSP2 0.62 14.39 0.49 6.78e-41 Multiple sclerosis; BRCA cis rs1865721 0.682 rs3745082 chr18:73142734 G/T cg26385618 chr18:73139727 C18orf62 -0.36 -9.0 -0.34 2.47e-18 Intelligence; BRCA cis rs4363385 0.747 rs1415961 chr1:152973464 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.25 -0.31 8.93e-16 Inflammatory skin disease; BRCA trans rs75804782 0.521 rs56120037 chr2:239398464 G/A cg01134436 chr17:81009848 B3GNTL1 0.68 8.66 0.32 3.77e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs149866169 1 rs149866169 chr6:27441723 T/A cg08798685 chr6:27730294 NA -0.71 -8.81 -0.33 1.17e-17 Neuroticism (multi-trait analysis);Lung cancer in ever smokers;Subjective well-being (multi-trait analysis);Lung cancer;Squamous cell lung carcinoma; BRCA cis rs3091242 0.933 rs10903129 chr1:25768937 A/G cg20684491 chr1:25596433 NA 0.31 8.16 0.31 1.74e-15 Erythrocyte sedimentation rate; BRCA cis rs7617773 0.780 rs9846818 chr3:48375685 C/T cg11946769 chr3:48343235 NME6 0.51 11.21 0.41 9.1e-27 Coronary artery disease; BRCA cis rs6450176 1.000 rs4334835 chr5:53300612 T/G ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.14 -0.51 1.8e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs4474465 0.850 rs10793326 chr11:78255422 A/C cg27205649 chr11:78285834 NARS2 0.34 9.73 0.36 5.75e-21 Alzheimer's disease (survival time); BRCA trans rs61931739 0.500 rs7971957 chr12:34477558 C/T cg26384229 chr12:38710491 ALG10B 0.59 13.52 0.47 7.99e-37 Morning vs. evening chronotype; BRCA cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg01884057 chr2:25150051 NA 0.34 9.04 0.34 1.88e-18 Body mass index; BRCA cis rs6594499 0.903 rs1438672 chr5:110467753 G/A cg04022379 chr5:110408740 TSLP 0.35 8.04 0.3 4.41e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.81 13.42 0.47 2.44e-36 Schizophrenia; BRCA cis rs56104184 0.723 rs73063524 chr19:49409004 T/C cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.9 -0.36 1.3e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg19784903 chr17:45786737 TBKBP1 0.34 8.06 0.3 3.7e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg27211696 chr2:191398769 TMEM194B 0.49 11.33 0.41 3.17e-27 Pulse pressure; BRCA trans rs6598955 0.671 rs3924325 chr1:26616320 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.66 -14.64 -0.5 4.83e-42 Obesity-related traits; BRCA cis rs11105298 0.891 rs4842662 chr12:89933446 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.54 -0.35 2.85e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs2731664 0.792 rs335420 chr5:176898619 C/T cg23176889 chr5:176863531 GRK6 0.59 15.54 0.52 1.92e-46 Intelligence (multi-trait analysis); BRCA cis rs61990749 0.597 rs4903643 chr14:78254791 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.66 9.86 0.36 1.92e-21 Fibroblast growth factor basic levels; BRCA cis rs589448 0.902 rs315131 chr12:69761839 T/G cg20891283 chr12:69753455 YEATS4 0.84 28.33 0.75 5.67e-115 Cerebrospinal fluid biomarker levels; BRCA cis rs6952808 1.000 rs4719319 chr7:1888094 G/A cg03354898 chr7:1950403 MAD1L1 -0.47 -9.35 -0.35 1.39e-19 Bipolar disorder and schizophrenia; BRCA cis rs1904096 0.506 rs28701470 chr4:95167088 A/C cg11021082 chr4:95130006 SMARCAD1 -0.43 -9.85 -0.36 2.06e-21 Type 2 diabetes; BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg08888203 chr3:10149979 C3orf24 0.6 12.56 0.45 1.68e-32 Alzheimer's disease; BRCA cis rs780096 0.545 rs6716894 chr2:27583273 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.31 -0.35 1.98e-19 Total body bone mineral density; BRCA cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg17971929 chr21:40555470 PSMG1 -0.64 -14.1 -0.49 1.72e-39 Cognitive function; BRCA cis rs754466 0.580 rs10824577 chr10:79577408 G/C cg17075019 chr10:79541650 NA -0.86 -23.55 -0.68 8.94e-89 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2762353 0.776 rs765285 chr6:25828242 G/C cg12310025 chr6:25882481 NA -0.54 -12.83 -0.45 1.04e-33 Blood metabolite levels; BRCA cis rs13191362 1.000 rs13218900 chr6:163081638 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.07 0.37 2.95e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3806843 0.868 rs2531342 chr5:140130612 C/T cg11822812 chr5:140052017 DND1 -0.31 -8.44 -0.32 2.18e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs12530845 0.943 rs58577912 chr7:135329269 T/G cg23117316 chr7:135346802 PL-5283 -0.37 -8.79 -0.33 1.36e-17 Red blood cell traits; BRCA cis rs4862750 0.872 rs6811569 chr4:187897988 A/G cg07414643 chr4:187882934 NA -0.27 -9.52 -0.35 3.52e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs724568 0.527 rs1430768 chr2:67929165 A/G cg17945962 chr2:67939740 NA -0.37 -9.85 -0.36 2.06e-21 Major depressive disorder (broad); BRCA trans rs10506458 1.000 rs1495013 chr12:63428188 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.16 -17.72 -0.57 1.9e-57 Hemostatic factors and hematological phenotypes; BRCA cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg05084668 chr3:125655381 ALG1L -0.47 -8.1 -0.31 2.84e-15 Blood pressure (smoking interaction); BRCA trans rs7618501 0.633 rs2883057 chr3:49998282 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.33 9.2 0.34 5.16e-19 Intelligence (multi-trait analysis); BRCA cis rs8017423 0.522 rs12887028 chr14:90819605 A/G cg04374321 chr14:90722782 PSMC1 -0.5 -11.92 -0.43 9.86e-30 Mortality in heart failure; BRCA cis rs7020830 0.867 rs563132 chr9:37245476 A/T cg14294708 chr9:37120828 ZCCHC7 1.06 32.0 0.78 7.28e-135 Schizophrenia; BRCA cis rs7072216 0.763 rs2147901 chr10:100165496 A/C cg26618903 chr10:100175079 PYROXD2 0.28 8.17 0.31 1.61e-15 Metabolite levels; BRCA cis rs2040771 0.804 rs2073754 chr22:19221406 G/T cg02655711 chr22:19163373 SLC25A1 -0.39 -9.09 -0.34 1.25e-18 Metabolite levels (small molecules and protein measures); BRCA cis rs10751667 1.000 rs7395632 chr11:958789 C/T ch.11.42038R chr11:967971 AP2A2 -0.54 -17.61 -0.57 7.07e-57 Alzheimer's disease (late onset); BRCA cis rs7312933 0.670 rs10880258 chr12:42547531 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -9.1 -0.34 1.17e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg23711669 chr6:146136114 FBXO30 0.72 16.53 0.55 2.2e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.822 rs979946 chr4:98921235 C/A cg17366294 chr4:99064904 C4orf37 0.42 9.76 0.36 4.4e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs1865760 0.713 rs1130000 chr6:25985396 A/G cg17691542 chr6:26056736 HIST1H1C 0.51 10.47 0.38 9.1e-24 Height; BRCA cis rs7789940 0.951 rs7787526 chr7:75947553 C/T cg10167463 chr7:75959203 YWHAG -0.45 -8.82 -0.33 1.06e-17 Multiple sclerosis; BRCA cis rs10267417 0.603 rs12666448 chr7:19859119 G/A cg07541023 chr7:19748670 TWISTNB 0.48 8.85 0.33 8.88e-18 Night sleep phenotypes; BRCA cis rs4689592 0.619 rs3796908 chr4:7061378 G/A cg02503808 chr4:7069936 GRPEL1 0.82 18.21 0.58 5.58e-60 Monocyte percentage of white cells; BRCA cis rs4713118 0.869 rs6902689 chr6:27709441 C/T cg26587870 chr6:27730563 NA -0.39 -8.29 -0.31 6.75e-16 Parkinson's disease; BRCA cis rs78707713 0.836 rs112843485 chr10:71211707 T/C cg12610070 chr10:71211762 TSPAN15 -0.32 -8.18 -0.31 1.54e-15 Venous thromboembolism; BRCA cis rs4949454 0.542 rs10914457 chr1:32094261 A/C cg13919466 chr1:32135498 COL16A1 0.25 8.11 0.31 2.65e-15 Intelligence (multi-trait analysis); BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg05793240 chr7:2802953 GNA12 -0.33 -8.12 -0.31 2.4e-15 Height; BRCA cis rs4363385 0.818 rs559236 chr1:153010510 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg05313129 chr8:58192883 C8orf71 -0.46 -9.44 -0.35 7e-20 Developmental language disorder (linguistic errors); BRCA cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg12667521 chr19:29218732 NA 0.47 8.68 0.32 3.4e-17 Methadone dose in opioid dependence; BRCA cis rs2153535 0.601 rs7775274 chr6:8530303 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.77e-24 Motion sickness; BRCA cis rs6484504 0.600 rs942272 chr11:31364368 C/T cg14844989 chr11:31128820 NA 0.46 9.59 0.35 1.88e-20 Red blood cell count; BRCA cis rs4665809 0.525 rs4665324 chr2:26447147 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.57 -9.85 -0.36 2.04e-21 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs11722272 chr4:99000839 C/T cg05340658 chr4:99064831 C4orf37 0.64 15.62 0.53 8.31e-47 Colonoscopy-negative controls vs population controls; BRCA cis rs2033711 0.870 rs7409473 chr19:58939165 A/G cg11952622 chr19:58962976 ZNF324B 0.43 8.86 0.33 7.99e-18 Uric acid clearance; BRCA cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg16482183 chr6:26056742 HIST1H1C 0.72 14.46 0.5 3.3e-41 Iron status biomarkers; BRCA cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg17971929 chr21:40555470 PSMG1 -0.72 -16.24 -0.54 6.36e-50 Cognitive function; BRCA cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg07493874 chr5:1342172 CLPTM1L -0.51 -14.88 -0.51 3.07e-43 Lung cancer; BRCA cis rs2153535 0.563 rs1737584 chr6:8536742 C/T cg21535247 chr6:8435926 SLC35B3 0.38 8.61 0.32 5.74e-17 Motion sickness; BRCA cis rs11098499 0.954 rs28429722 chr4:120300093 G/A cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs11711311 1.000 rs2566970 chr3:113462123 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 0.46 10.27 0.38 5.04e-23 IgG glycosylation; BRCA cis rs9733 0.526 rs11204698 chr1:150659545 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.7e-15 Tonsillectomy; BRCA cis rs7209700 0.889 rs11079769 chr17:45349731 A/T cg08085267 chr17:45401833 C17orf57 0.43 7.96 0.3 7.89e-15 IgG glycosylation; BRCA cis rs57221529 0.825 rs7443550 chr5:578404 G/T cg09021430 chr5:549028 NA -0.68 -14.24 -0.49 3.68e-40 Lung disease severity in cystic fibrosis; BRCA cis rs9296092 0.538 rs34222093 chr6:33519584 G/C cg13560919 chr6:33536144 NA -0.85 -18.66 -0.59 2.26e-62 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg24531977 chr5:56204891 C5orf35 0.73 16.06 0.54 5.03e-49 Initial pursuit acceleration; BRCA cis rs8177253 1.000 rs8177253 chr3:133480192 A/G cg01448562 chr3:133502909 NA 0.62 14.97 0.51 1.23e-43 Iron status biomarkers; BRCA cis rs1008375 0.966 rs4235391 chr4:17696409 A/G cg15017067 chr4:17643749 FAM184B 0.26 7.81 0.3 2.31e-14 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2739330 0.828 rs5760107 chr22:24252597 T/C cg10819733 chr22:24237672 NA -0.3 -8.16 -0.31 1.85e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7824557 0.767 rs2164272 chr8:11162496 A/C cg21775007 chr8:11205619 TDH 0.61 11.79 0.42 3.48e-29 Retinal vascular caliber; BRCA cis rs9457247 0.765 rs1322077 chr6:167424293 T/C cg23791538 chr6:167370224 RNASET2 -0.42 -10.07 -0.37 3.04e-22 Crohn's disease; BRCA cis rs17376456 0.542 rs2084916 chr5:93194961 A/T cg25358565 chr5:93447407 FAM172A -0.65 -11.23 -0.41 7.98e-27 Diabetic retinopathy; BRCA cis rs796364 0.715 rs1106399 chr2:201003837 A/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.53 -8.42 -0.32 2.48e-16 Schizophrenia; BRCA trans rs2727020 0.930 rs1164688 chr11:49290604 C/G cg15704280 chr7:45808275 SEPT13 0.75 16.09 0.54 3.61e-49 Coronary artery disease; BRCA cis rs35110281 0.627 rs7282704 chr21:44966253 A/G cg01579765 chr21:45077557 HSF2BP -0.34 -8.79 -0.33 1.32e-17 Mean corpuscular volume; BRCA cis rs654950 0.774 rs941972 chr1:42040740 T/C cg06885757 chr1:42089581 HIVEP3 -0.3 -10.21 -0.37 8.63e-23 Airway imaging phenotypes; BRCA cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.77 -0.55 1.45e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9814567 0.806 rs4074522 chr3:134325626 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.36 8.17 0.31 1.6e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs637571 0.522 rs493899 chr11:65747952 A/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.6 13.7 0.48 1.22e-37 Eosinophil percentage of white cells; BRCA cis rs4594175 0.926 rs4901084 chr14:51634131 G/A cg23942311 chr14:51606299 NA 0.33 8.29 0.31 6.56e-16 Cancer; BRCA cis rs36051895 0.625 rs12340344 chr9:5176281 C/A cg02405213 chr9:5042618 JAK2 -0.47 -8.92 -0.33 5.05e-18 Pediatric autoimmune diseases; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg03188948 chr7:1209495 NA 0.45 8.74 0.33 1.99e-17 Longevity;Endometriosis; BRCA cis rs9868809 0.505 rs11706203 chr3:48746239 T/A cg07636037 chr3:49044803 WDR6 -0.58 -8.14 -0.31 2.09e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs8030485 0.536 rs1915724 chr15:79441027 A/G cg17916960 chr15:79447300 NA 0.39 9.45 0.35 6.44e-20 Left ventricle wall thickness; BRCA cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.66 -15.05 -0.51 5.01e-44 Axial length; BRCA cis rs7760949 0.963 rs9475771 chr6:13914869 A/G cg27413430 chr6:13925136 RNF182 -0.37 -7.85 -0.3 1.7e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs8180040 0.587 rs1466741 chr3:47247214 C/T cg16586182 chr3:47516702 SCAP 0.56 12.5 0.44 3.02e-32 Colorectal cancer; BRCA cis rs9487023 1 rs9487023 chr6:109590004 A/G cg01475377 chr6:109611718 NA -0.51 -12.85 -0.45 9.18e-34 Red blood cell count;Mean corpuscular hemoglobin concentration;Neutrophil percentage of white cells;Lymphocyte percentage of white cells;Mean corpuscular hemoglobin;High light scatter reticulocyte percentage of red cells;Mean corpuscular volume; BRCA cis rs600231 0.706 rs3782091 chr11:65336483 G/T cg01292856 chr11:65242576 NA -0.33 -7.82 -0.3 2.26e-14 Bone mineral density; BRCA cis rs2836950 0.545 rs2836922 chr21:40516308 C/T cg11644478 chr21:40555479 PSMG1 -0.47 -9.81 -0.36 2.98e-21 Menarche (age at onset); BRCA cis rs6952808 0.595 rs3800917 chr7:2167939 A/G cg05863683 chr7:1912471 MAD1L1 -0.4 -8.57 -0.32 7.88e-17 Bipolar disorder and schizophrenia; BRCA cis rs6088813 1.000 rs2425066 chr20:33927006 A/C cg14752227 chr20:34000481 UQCC 0.4 8.49 0.32 1.43e-16 Height; BRCA cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg08859206 chr1:53392774 SCP2 -0.51 -11.21 -0.41 9.67e-27 Monocyte count; BRCA cis rs8062405 0.964 rs9972768 chr16:28861734 A/C cg16576597 chr16:28551801 NUPR1 0.29 8.25 0.31 9.34e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg04267008 chr7:1944627 MAD1L1 -0.6 -13.01 -0.46 1.7e-34 Bipolar disorder and schizophrenia; BRCA cis rs7100689 0.784 rs7895042 chr10:82095276 G/A cg00277334 chr10:82204260 NA -0.42 -8.01 -0.3 5.35e-15 Post bronchodilator FEV1; BRCA cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA trans rs58106596 0.950 rs11695646 chr2:232584807 C/T cg01370599 chr3:116745421 NA -0.32 -8.77 -0.33 1.57e-17 White blood cell count;Lymphocyte counts; BRCA cis rs8103278 1.000 rs11671524 chr19:46327166 G/A cg11657440 chr19:46296263 DMWD -0.55 -12.91 -0.45 4.63e-34 Coronary artery disease; BRCA cis rs2153535 0.546 rs9378559 chr6:8539058 A/T cg21535247 chr6:8435926 SLC35B3 0.4 8.91 0.33 5.22e-18 Motion sickness; BRCA cis rs3617 0.573 rs9810807 chr3:52924227 C/T cg11645453 chr3:52864694 ITIH4 -0.37 -9.76 -0.36 4.41e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs208520 0.526 rs2881644 chr6:66803535 A/C cg07460842 chr6:66804631 NA 1.13 35.62 0.82 6.44e-154 Exhaled nitric oxide output; BRCA trans rs61931739 0.500 rs34997501 chr12:34549828 C/G cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs2645694 0.626 rs2703140 chr4:77830057 C/G cg06046430 chr4:77819534 ANKRD56 0.58 12.7 0.45 3.94e-33 Emphysema distribution in smoking; BRCA cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg03808351 chr9:123631620 PHF19 0.39 7.81 0.3 2.39e-14 Rheumatoid arthritis; BRCA trans rs61931739 0.500 rs11053246 chr12:34516620 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs546131 0.928 rs516228 chr11:34838823 C/T cg11058730 chr11:34937778 PDHX;APIP 0.45 8.6 0.32 6.13e-17 Lung disease severity in cystic fibrosis; BRCA cis rs3815700 0.844 rs444089 chr19:33106991 G/C cg02997394 chr19:33096574 ANKRD27 0.66 10.14 0.37 1.67e-22 Eosinophilic esophagitis; BRCA trans rs877282 0.853 rs7092652 chr10:756109 G/A cg22713356 chr15:30763199 NA 1.25 20.77 0.63 1.25e-73 Uric acid levels; BRCA cis rs7586879 0.861 rs10164466 chr2:25114069 T/C cg04586622 chr2:25135609 ADCY3 0.4 9.63 0.36 1.35e-20 Body mass index; BRCA cis rs7584330 0.780 rs937395 chr2:238378749 T/C cg14458575 chr2:238380390 NA 0.5 11.51 0.41 5.23e-28 Prostate cancer; BRCA cis rs853679 0.517 rs9393897 chr6:28127710 G/T cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.96 0.3 7.63e-15 Depression; BRCA cis rs17270561 0.636 rs7754814 chr6:25745243 A/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg18402987 chr7:1209562 NA 0.87 12.28 0.44 2.89e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs769267 0.965 rs12460764 chr19:19431963 G/T cg03709012 chr19:19516395 GATAD2A -0.75 -16.92 -0.56 2.43e-53 Tonsillectomy; BRCA trans rs11098499 0.863 rs10018280 chr4:120478139 T/G cg25214090 chr10:38739885 LOC399744 0.51 11.51 0.41 5.53e-28 Corneal astigmatism; BRCA cis rs12142240 0.698 rs3991877 chr1:46853749 C/A cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg23285459 chr7:2802560 GNA12 -0.33 -8.51 -0.32 1.29e-16 Height; BRCA cis rs2032447 0.575 rs198847 chr6:26106619 C/A cg03264133 chr6:25882463 NA 0.41 8.71 0.33 2.61e-17 Intelligence (multi-trait analysis); BRCA cis rs4319547 0.620 rs12372756 chr12:122815130 A/G cg23029597 chr12:123009494 RSRC2 -0.59 -11.43 -0.41 1.19e-27 Body mass index; BRCA cis rs769267 0.895 rs2905435 chr19:19495954 G/A cg03709012 chr19:19516395 GATAD2A -0.81 -18.76 -0.6 6.65e-63 Tonsillectomy; BRCA cis rs7592578 0.882 rs2192010 chr2:191462133 C/T cg27211696 chr2:191398769 TMEM194B -0.47 -7.88 -0.3 1.39e-14 Diastolic blood pressure; BRCA trans rs11227306 0.934 rs10896056 chr11:65587905 A/G cg17712092 chr4:129076599 LARP1B 0.42 8.73 0.33 2.3e-17 DNA methylation (variation); BRCA cis rs3771570 0.901 rs62190410 chr2:242410621 C/T cg21155796 chr2:242212141 HDLBP 0.62 9.56 0.35 2.44e-20 Prostate cancer; BRCA cis rs1348850 0.574 rs12988366 chr2:178417945 A/C cg27490568 chr2:178487706 NA -0.54 -9.23 -0.34 4.06e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg11941060 chr3:133502564 NA -0.57 -13.72 -0.48 9.4e-38 Iron status biomarkers; BRCA cis rs35306767 0.903 rs12264711 chr10:929525 T/C cg26597838 chr10:835615 NA 1.03 18.26 0.59 3.04e-60 Eosinophil percentage of granulocytes; BRCA cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg11764359 chr7:65958608 NA -0.62 -13.42 -0.47 2.4e-36 Aortic root size; BRCA cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg01858014 chr14:56050164 KTN1 -0.73 -10.81 -0.39 3.79e-25 Putamen volume; BRCA trans rs61931739 0.534 rs12371021 chr12:34062252 T/C cg26384229 chr12:38710491 ALG10B 0.68 14.12 0.49 1.27e-39 Morning vs. evening chronotype; BRCA cis rs7737355 0.947 rs244736 chr5:130816178 T/C cg06307176 chr5:131281290 NA 0.54 11.21 0.41 9.6800000000000007e-27 Life satisfaction; BRCA trans rs61931739 0.500 rs11053210 chr12:34461771 A/G cg13010199 chr12:38710504 ALG10B -0.48 -9.16 -0.34 6.85e-19 Morning vs. evening chronotype; BRCA cis rs9443645 0.901 rs9352669 chr6:79584141 T/G cg05283184 chr6:79620031 NA -0.43 -11.22 -0.41 8.77e-27 Intelligence (multi-trait analysis); BRCA cis rs2153535 0.601 rs1737581 chr6:8539138 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.7 0.33 2.74e-17 Motion sickness; BRCA cis rs7903847 0.642 rs10882909 chr10:99137998 G/C cg20016023 chr10:99160130 RRP12 -0.27 -8.66 -0.32 3.9e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs72781680 0.898 rs72780118 chr2:23994431 G/A cg08917208 chr2:24149416 ATAD2B 0.9 13.16 0.46 3.7e-35 Lymphocyte counts; BRCA cis rs7918232 0.830 rs7915902 chr10:27410734 T/C cg14442939 chr10:27389572 ANKRD26 0.66 10.92 0.4 1.5e-25 Breast cancer; BRCA cis rs4727027 0.899 rs6464942 chr7:148826368 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 9.02 0.34 2.2e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2249625 0.904 rs2496514 chr6:72904071 A/G cg18830697 chr6:72922368 RIMS1 -0.38 -8.13 -0.31 2.28e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs2115630 1.000 rs11854313 chr15:85304048 G/C cg12863693 chr15:85201151 NMB -0.34 -8.01 -0.3 5.38e-15 P wave terminal force; BRCA cis rs2742234 0.578 rs2435354 chr10:43652445 C/T cg15436174 chr10:43711423 RASGEF1A -0.56 -11.28 -0.41 4.68e-27 Hirschsprung disease; BRCA cis rs4363385 0.617 rs5010885 chr1:152973141 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.79 -0.36 3.44e-21 Inflammatory skin disease; BRCA cis rs1506636 1.000 rs641491 chr7:123399726 C/A cg03229431 chr7:123269106 ASB15 0.61 13.78 0.48 4.97e-38 Plateletcrit;Platelet count; BRCA cis rs250677 0.687 rs36043 chr5:148440983 G/A cg18129178 chr5:148520854 ABLIM3 -0.6 -12.33 -0.44 1.76e-31 Breast cancer; BRCA cis rs6740322 0.793 rs13414908 chr2:43546658 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -12.09 -0.43 1.88e-30 Coronary artery disease; BRCA cis rs60871478 0.704 rs62432895 chr7:822050 C/G cg04727924 chr7:799746 HEATR2 -0.57 -11.25 -0.41 6.38e-27 Cerebrospinal P-tau181p levels; BRCA cis rs8180040 0.620 rs17784127 chr3:47061700 T/C cg27129171 chr3:47204927 SETD2 -0.71 -17.11 -0.56 2.72e-54 Colorectal cancer; BRCA cis rs2933343 0.553 rs789212 chr3:128686912 A/C cg11901034 chr3:128598214 ACAD9 -0.34 -8.13 -0.31 2.26e-15 IgG glycosylation; BRCA cis rs7772486 0.754 rs4566902 chr6:146244128 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.25 0.34 3.38e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs9814567 1.000 rs9809619 chr3:134280948 G/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.87 -0.3 1.54e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs59918340 0.728 rs10875467 chr8:142233396 A/C cg18755752 chr8:142205143 DENND3 0.37 8.18 0.31 1.49e-15 Immature fraction of reticulocytes; BRCA cis rs10504229 0.906 rs7003285 chr8:58173108 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs10504229 1.000 rs66936919 chr8:58172868 C/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.63 -0.36 1.33e-20 Developmental language disorder (linguistic errors); BRCA cis rs7927771 0.793 rs12803525 chr11:47413475 G/A cg18512352 chr11:47633146 NA -0.33 -8.15 -0.31 1.99e-15 Subjective well-being; BRCA cis rs61990749 0.544 rs2544567 chr14:78181739 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.64 10.06 0.37 3.36e-22 Fibroblast growth factor basic levels; BRCA cis rs6546550 0.901 rs7598283 chr2:70128717 A/G cg02498382 chr2:70120550 SNRNP27 -0.52 -11.47 -0.41 7.91e-28 Prevalent atrial fibrillation; BRCA cis rs12477438 0.520 rs13023744 chr2:99738224 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.21 0.68 7.15e-87 Chronic sinus infection; BRCA cis rs8114671 0.585 rs2236271 chr20:33523840 G/T cg07148914 chr20:33460835 GGT7 -0.45 -9.74 -0.36 5.56e-21 Height; BRCA cis rs2075371 0.933 rs1868785 chr7:133945855 G/C cg11752832 chr7:134001865 SLC35B4 0.49 12.1 0.43 1.76e-30 Mean platelet volume; BRCA cis rs4742903 0.935 rs10120101 chr9:107000909 C/T cg14250997 chr9:106856677 SMC2 0.28 8.98 0.33 2.99e-18 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7618915 0.547 rs11709448 chr3:52647449 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.15 0.4 1.64e-26 Bipolar disorder; BRCA cis rs7044106 0.791 rs10818473 chr9:123484155 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.76 17.27 0.56 3.87e-55 Hip circumference adjusted for BMI; BRCA cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg21427119 chr20:30132790 HM13 -0.42 -8.92 -0.33 4.92e-18 Mean corpuscular hemoglobin; BRCA trans rs9388451 0.657 rs4895799 chr6:126052729 C/T cg05039488 chr6:79577232 IRAK1BP1 -0.44 -9.95 -0.37 8.46e-22 Brugada syndrome; BRCA cis rs806795 0.605 rs809871 chr6:26256526 C/G cg13736514 chr6:26305472 NA 0.39 11.88 0.43 1.52e-29 Mosquito bite size; BRCA cis rs1200821 0.535 rs1208784 chr10:37768433 A/G cg25427524 chr10:38739819 LOC399744 -0.44 -9.27 -0.34 2.91e-19 Hemostatic factors and hematological phenotypes; BRCA cis rs9393777 0.513 rs9393737 chr6:26617306 A/G cg12826209 chr6:26865740 GUSBL1 -0.58 -10.23 -0.38 7.51e-23 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.771 rs10244946 chr7:1921068 A/G cg03354898 chr7:1950403 MAD1L1 0.47 10.5 0.38 6.59e-24 Bipolar disorder and schizophrenia; BRCA cis rs7598759 0.712 rs6727510 chr2:232332016 T/C cg19187155 chr2:232395269 NMUR1 0.37 7.83 0.3 2.1e-14 Noise-induced hearing loss; BRCA cis rs10751667 0.621 rs7396107 chr11:970029 C/T cg01483505 chr11:975446 AP2A2 0.33 9.09 0.34 1.25e-18 Alzheimer's disease (late onset); BRCA trans rs2727020 0.530 rs7113153 chr11:49457957 G/A cg15704280 chr7:45808275 SEPT13 -0.72 -14.42 -0.5 4.89e-41 Coronary artery disease; BRCA cis rs4074536 0.547 rs7527858 chr1:116288105 C/T cg21648376 chr1:116311395 CASQ2 -0.49 -8.68 -0.32 3.25e-17 QRS duration; BRCA cis rs9287719 0.649 rs12617968 chr2:10721945 C/T cg00105475 chr2:10696890 NA 0.41 9.17 0.34 6.17e-19 Prostate cancer; BRCA cis rs1003719 0.679 rs2835638 chr21:38534533 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.62 -14.54 -0.5 1.43e-41 Eye color traits; BRCA cis rs2153535 0.504 rs9405393 chr6:8467432 G/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs4891159 0.790 rs11872411 chr18:74132051 C/T cg24786174 chr18:74118243 ZNF516 -0.75 -18.66 -0.59 2.26e-62 Longevity; BRCA cis rs2204008 0.805 rs11522896 chr12:38234427 T/C cg26384229 chr12:38710491 ALG10B 0.76 16.93 0.56 2.14e-53 Bladder cancer; BRCA cis rs2019137 0.936 rs3811059 chr2:113962071 C/T cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.74 -0.39 7.58e-25 Lymphocyte counts; BRCA cis rs72615157 0.561 rs113401658 chr7:99858505 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.7 11.62 0.42 1.98e-28 Lung function (FEV1/FVC); BRCA cis rs6570726 0.935 rs366621 chr6:145861275 A/G cg23711669 chr6:146136114 FBXO30 0.63 14.47 0.5 2.87e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs1797081 0.811 rs1797076 chr10:16853076 A/G cg23933602 chr10:16859644 RSU1 0.88 24.01 0.69 2.75e-91 Platelet distribution width; BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg27170947 chr2:26402098 FAM59B -0.92 -16.84 -0.55 6.2e-53 Gut microbiome composition (summer); BRCA cis rs6912958 0.781 rs1051148 chr6:88221892 T/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.5 -0.32 1.38e-16 Monocyte percentage of white cells; BRCA cis rs11955398 0.521 rs4298206 chr5:60012235 T/C cg02684056 chr5:59996105 DEPDC1B -0.41 -9.61 -0.36 1.6e-20 Intelligence (multi-trait analysis); BRCA cis rs3008870 0.755 rs2815363 chr1:67497221 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.59 -12.93 -0.46 3.77e-34 Lymphocyte percentage of white cells; BRCA cis rs921968 0.541 rs3755041 chr2:219442499 A/T cg02176678 chr2:219576539 TTLL4 -0.51 -13.07 -0.46 9.29e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs7727544 1.000 rs7727038 chr5:131590257 C/T cg18758796 chr5:131593413 PDLIM4 0.31 8.12 0.31 2.35e-15 Blood metabolite levels; BRCA cis rs12950390 0.853 rs56137679 chr17:45862112 C/G cg03474202 chr17:45855739 NA -0.46 -12.23 -0.44 4.53e-31 IgG glycosylation; BRCA cis rs10044254 0.563 rs4702102 chr5:15698919 A/T cg07238450 chr5:15720153 FBXL7 -0.38 -8.08 -0.3 3.15e-15 Asthma (corticosteroid response); BRCA cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg05985134 chr18:33552581 C18orf21 0.64 12.31 0.44 2.12e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2806561 0.808 rs4654834 chr1:23364919 T/C cg19743168 chr1:23544995 NA -0.42 -9.96 -0.37 7.88e-22 Height; BRCA trans rs1493916 0.837 rs11876492 chr18:31413804 T/C cg27147174 chr7:100797783 AP1S1 -0.43 -8.73 -0.33 2.16e-17 Life satisfaction; BRCA cis rs67460515 0.892 rs11710489 chr3:161093332 G/A cg03342759 chr3:160939853 NMD3 -0.71 -16.08 -0.54 4.29e-49 Parkinson's disease; BRCA cis rs4975709 0.589 rs1684967 chr5:1863055 G/C cg20790798 chr5:1857306 NA -0.35 -7.94 -0.3 8.86e-15 Cardiovascular disease risk factors; BRCA cis rs6088813 0.925 rs1540928 chr20:33961845 C/A cg14752227 chr20:34000481 UQCC -0.41 -8.72 -0.33 2.36e-17 Height; BRCA cis rs11098499 0.866 rs13105020 chr4:120285688 G/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA trans rs11098499 0.909 rs79026312 chr4:120440677 C/A cg25214090 chr10:38739885 LOC399744 0.55 12.05 0.43 2.91e-30 Corneal astigmatism; BRCA cis rs12618769 0.597 rs3769712 chr2:99153443 A/T cg10123293 chr2:99228465 UNC50 0.44 8.5 0.32 1.3e-16 Bipolar disorder; BRCA cis rs11098499 0.954 rs7436506 chr4:120393769 T/C cg09307838 chr4:120376055 NA 0.75 16.23 0.54 7.77e-50 Corneal astigmatism; BRCA cis rs780096 0.526 rs7602534 chr2:27592423 C/T cg12000995 chr2:27665139 KRTCAP3 -0.32 -8.3 -0.31 6.02e-16 Total body bone mineral density; BRCA cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg13010199 chr12:38710504 ALG10B 0.51 9.99 0.37 6.08e-22 Morning vs. evening chronotype; BRCA cis rs4665809 0.887 rs6546716 chr2:26263836 A/G cg26314531 chr2:26401878 FAM59B -0.65 -11.17 -0.4 1.42e-26 Gut microbiome composition (summer); BRCA cis rs2204008 0.624 rs2320449 chr12:38224190 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs6088580 0.634 rs6142164 chr20:33006597 C/T cg08999081 chr20:33150536 PIGU -0.44 -12.38 -0.44 1.01e-31 Glomerular filtration rate (creatinine); BRCA trans rs8002861 0.935 rs4101376 chr13:44469835 C/T cg17145862 chr1:211918768 LPGAT1 -0.73 -19.26 -0.61 1.49e-65 Leprosy; BRCA cis rs7267979 0.899 rs2104734 chr20:25526668 A/G cg08601574 chr20:25228251 PYGB 0.35 8.3 0.31 6.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6831352 0.918 rs2851253 chr4:100043505 G/T cg12011299 chr4:100065546 ADH4 -0.5 -11.55 -0.42 3.59e-28 Alcohol dependence; BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg25703541 chr22:24373054 LOC391322 0.67 15.21 0.52 7.96e-45 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6570726 0.755 rs2103633 chr6:145894021 C/T cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.2e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs2882667 0.861 rs10037106 chr5:138365490 G/T cg04439458 chr5:138467593 SIL1 -0.32 -8.77 -0.33 1.62e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1865760 0.566 rs9379825 chr6:26083871 C/A cg17691542 chr6:26056736 HIST1H1C 0.56 11.84 0.42 2.28e-29 Height; BRCA trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.05e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs561341 0.941 rs17780086 chr17:30343282 G/A cg12193833 chr17:30244370 NA -0.57 -8.43 -0.32 2.29e-16 Hip circumference adjusted for BMI; BRCA cis rs6495367 1.000 rs13380104 chr15:79378821 C/T cg17916960 chr15:79447300 NA 0.32 8.16 0.31 1.77e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7131987 0.845 rs2042511 chr12:29408780 C/T cg09582351 chr12:29534625 ERGIC2 -0.47 -11.56 -0.42 3.34e-28 QT interval; BRCA cis rs67478160 0.619 rs12897150 chr14:104319530 A/T cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.88 -0.4 2.11e-25 Schizophrenia; BRCA cis rs9443645 0.808 rs2050661 chr6:79661125 T/C cg09184832 chr6:79620586 NA -0.5 -11.16 -0.4 1.48e-26 Intelligence (multi-trait analysis); BRCA cis rs939658 1.000 rs8031019 chr15:79458512 C/T cg17916960 chr15:79447300 NA -0.39 -9.92 -0.37 1.1e-21 Refractive error; BRCA cis rs1153858 0.943 rs12439575 chr15:45684816 T/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.59 0.42 2.61e-28 Homoarginine levels; BRCA cis rs9868809 0.505 rs11706983 chr3:48738678 A/G cg00383909 chr3:49044727 WDR6 0.6 11.0 0.4 6.96e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA trans rs208520 1.000 rs12189683 chr6:66977716 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.86 -14.88 -0.51 3.14e-43 Exhaled nitric oxide output; BRCA cis rs7666738 0.761 rs1456210 chr4:98645932 T/G cg05340658 chr4:99064831 C4orf37 0.62 14.5 0.5 2.19e-41 Colonoscopy-negative controls vs population controls; BRCA trans rs9951602 0.573 rs8098953 chr18:76648734 A/G cg02800362 chr5:177631904 HNRNPAB 0.78 18.26 0.59 2.77e-60 Obesity-related traits; BRCA cis rs10540 1.000 rs12794284 chr11:477623 C/T cg08088566 chr11:430123 ANO9 0.55 7.85 0.3 1.74e-14 Body mass index; BRCA cis rs6089829 0.962 rs1116450 chr20:61658210 T/C cg02544614 chr20:61657117 NA 0.28 7.81 0.3 2.32e-14 Prostate cancer (SNP x SNP interaction); BRCA cis rs763014 0.966 rs4984904 chr16:680809 C/G cg07256732 chr16:621771 PIGQ -0.34 -8.9 -0.33 5.58e-18 Height; BRCA cis rs1707322 1.000 rs4660334 chr1:46462126 A/C cg06784218 chr1:46089804 CCDC17 0.46 10.88 0.4 2.1e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg00745463 chr17:30367425 LRRC37B -0.62 -9.87 -0.36 1.73e-21 Hip circumference adjusted for BMI; BRCA cis rs10503871 1.000 rs10503871 chr8:30436852 A/G cg26383811 chr8:30366931 RBPMS -0.32 -8.63 -0.32 4.91e-17 Metabolite levels (X-11787); BRCA cis rs1005277 0.579 rs2472178 chr10:38384750 T/C cg00409905 chr10:38381863 ZNF37A -0.57 -12.44 -0.44 5.9e-32 Extrinsic epigenetic age acceleration; BRCA cis rs1832871 0.541 rs10945546 chr6:158892209 A/G cg07165851 chr6:158734300 TULP4 0.47 9.35 0.35 1.46e-19 Height; BRCA cis rs6484504 0.532 rs10835757 chr11:31281902 C/T cg14844989 chr11:31128820 NA -0.44 -9.34 -0.35 1.56e-19 Red blood cell count; BRCA cis rs6901250 0.788 rs571296 chr6:117092558 A/G cg12892004 chr6:117198278 RFX6 -0.45 -10.62 -0.39 2.22e-24 C-reactive protein levels; BRCA cis rs10504229 0.728 rs17804720 chr8:58154565 T/C cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs1801251 1.000 rs283469 chr2:233656997 G/T cg08000102 chr2:233561755 GIGYF2 0.62 13.74 0.48 8.31e-38 Coronary artery disease; BRCA cis rs868036 0.718 rs4776982 chr15:68114974 C/T cg24579218 chr15:68104479 NA 0.33 8.04 0.3 4.48e-15 Restless legs syndrome; BRCA cis rs4363385 0.818 rs1048296 chr1:153012240 A/C cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg10802521 chr3:52805072 NEK4 -0.31 -7.89 -0.3 1.35e-14 Bipolar disorder; BRCA cis rs6878727 0.526 rs149445 chr5:123680698 G/A cg01806427 chr5:123737813 NA -0.39 -8.0 -0.3 5.77e-15 Breast cancer; BRCA cis rs7582180 0.652 rs11678158 chr2:100932297 T/C cg14675211 chr2:100938903 LONRF2 0.51 11.77 0.42 4.61e-29 Intelligence (multi-trait analysis); BRCA cis rs2624839 0.704 rs13067082 chr3:50221715 A/G cg05623727 chr3:50126028 RBM5 -0.39 -8.42 -0.32 2.5e-16 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg08885076 chr2:99613938 TSGA10 -0.52 -11.83 -0.42 2.45e-29 Chronic sinus infection; BRCA cis rs7647973 1.000 rs10865956 chr3:49581559 C/A cg07636037 chr3:49044803 WDR6 0.71 15.32 0.52 2.25e-45 Menarche (age at onset); BRCA cis rs13102973 0.899 rs11735890 chr4:135902143 A/G cg14419869 chr4:135874104 NA 0.46 9.22 0.34 4.42e-19 Subjective well-being; BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg16590910 chr6:42928470 GNMT 0.36 7.81 0.3 2.35e-14 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs1459104 0.759 rs7939392 chr11:55257285 C/T cg03929089 chr4:120376271 NA 0.54 8.74 0.33 2.04e-17 Body mass index; BRCA trans rs2197308 0.643 rs1842597 chr12:37862142 C/G cg06521331 chr12:34319734 NA 0.46 8.93 0.33 4.55e-18 Morning vs. evening chronotype; BRCA cis rs9341808 0.754 rs9341810 chr6:80974838 G/A cg08355045 chr6:80787529 NA 0.37 9.56 0.35 2.58e-20 Sitting height ratio; BRCA cis rs6724607 1.000 rs6434402 chr2:191469322 C/T cg11845111 chr2:191398756 TMEM194B -0.36 -8.42 -0.32 2.49e-16 Pulse pressure; BRCA cis rs6088580 0.524 rs11167241 chr20:33250835 C/T cg08999081 chr20:33150536 PIGU -0.34 -8.8 -0.33 1.26e-17 Glomerular filtration rate (creatinine); BRCA cis rs875971 0.545 rs6979636 chr7:65741625 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.51 0.38 6.04e-24 Aortic root size; BRCA cis rs690037 0.673 rs690573 chr3:16376440 G/T cg23474789 chr3:16306055 DPH3;OXNAD1 -0.41 -8.47 -0.32 1.71e-16 Optic nerve measurement (cup-to-disc ratio);Optic nerve measurement (cup area); BRCA cis rs4665809 1.000 rs7588802 chr2:26277789 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.66 -12.01 -0.43 4.19e-30 Gut microbiome composition (summer); BRCA cis rs2288073 0.965 rs6545338 chr2:24422156 C/T cg26838691 chr2:24397539 C2orf84 -0.49 -8.87 -0.33 7.07e-18 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs9287719 0.934 rs6432111 chr2:10744620 A/C cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs9818758 0.556 rs11716614 chr3:49017208 C/G cg00383909 chr3:49044727 WDR6 0.96 13.4 0.47 2.89e-36 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1707322 1.000 rs10890372 chr1:46391020 T/G cg03146154 chr1:46216737 IPP 0.46 10.24 0.38 7.01e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6570726 0.935 rs416987 chr6:145847005 G/C cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs9790314 1.000 rs7653361 chr3:160992291 C/T cg03342759 chr3:160939853 NMD3 -0.63 -13.25 -0.46 1.38e-35 Morning vs. evening chronotype; BRCA cis rs4566357 0.615 rs10198406 chr2:227913539 A/G cg11843606 chr2:227700838 RHBDD1 -0.42 -9.4 -0.35 9.56e-20 Coronary artery disease; BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.35 0.35 1.49e-19 Tonsillectomy; BRCA cis rs113835537 0.529 rs75683511 chr11:66275026 A/G cg24851651 chr11:66362959 CCS 0.5 8.74 0.33 2.05e-17 Airway imaging phenotypes; BRCA cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs7707921 0.881 rs17243791 chr5:81322547 A/G cg15871215 chr5:81402204 ATG10 -0.38 -7.97 -0.3 7.37e-15 Breast cancer; BRCA cis rs7555523 0.778 rs2790052 chr1:165738463 G/C cg24409356 chr1:165738333 TMCO1 0.51 8.26 0.31 8.67e-16 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs7312933 0.703 rs1059360 chr12:42554505 A/G cg01256987 chr12:42539512 GXYLT1 -0.46 -9.05 -0.34 1.7e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs9463078 0.553 rs227837 chr6:44683123 A/G cg25276700 chr6:44698697 NA -0.39 -8.53 -0.32 1.1e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4819052 0.851 rs2838849 chr21:46671027 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.61 0.36 1.7e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12612619 0.732 rs11677841 chr2:27239949 G/T cg00617064 chr2:27272375 NA -0.32 -8.49 -0.32 1.44e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7631605 0.905 rs1468712 chr3:37106013 C/T cg15934958 chr3:37212084 LRRFIP2 -0.46 -10.68 -0.39 1.27e-24 Cerebrospinal P-tau181p levels; BRCA cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg06494592 chr3:125709126 NA -0.54 -8.58 -0.32 7.14e-17 Blood pressure (smoking interaction); BRCA cis rs9443645 0.901 rs4147183 chr6:79557046 C/G cg11833968 chr6:79620685 NA -0.44 -9.97 -0.37 7.34e-22 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.61 9.73 0.36 6.08e-21 Renal function-related traits (BUN); BRCA cis rs7246967 0.673 rs2361021 chr19:22816324 T/G cg23217946 chr19:22817039 ZNF492 0.47 8.45 0.32 2e-16 Bronchopulmonary dysplasia; BRCA cis rs7011049 0.915 rs11997706 chr8:53833202 T/G cg26025543 chr8:53854495 NA 0.55 9.92 0.37 1.1e-21 Systolic blood pressure; BRCA cis rs9611519 0.507 rs12484525 chr22:41443877 G/C cg03806693 chr22:41940476 POLR3H -0.46 -8.79 -0.33 1.39e-17 Neuroticism; BRCA cis rs7572733 0.515 rs35730302 chr2:198818626 A/T cg00792783 chr2:198669748 PLCL1 -0.46 -10.03 -0.37 4.24e-22 Dermatomyositis; BRCA cis rs765787 0.530 rs7167389 chr15:45535683 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.28 -0.41 5e-27 Uric acid levels; BRCA cis rs4845875 0.559 rs4846047 chr1:11843632 C/G cg06193043 chr1:11908199 NPPA 0.35 7.95 0.3 8.18e-15 Midregional pro atrial natriuretic peptide levels; BRCA cis rs870825 0.616 rs7678864 chr4:185635158 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.57 0.57 1.07e-56 Blood protein levels; BRCA cis rs698833 0.962 rs698830 chr2:44730863 G/C cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.7 0.36 7.9e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs477692 1.000 rs4750759 chr10:131436603 G/A cg05714579 chr10:131428358 MGMT -0.45 -10.6 -0.39 2.67e-24 Response to temozolomide; BRCA cis rs1577917 1.000 rs11759855 chr6:86610841 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.49 -13.07 -0.46 9.55e-35 Response to antipsychotic treatment; BRCA cis rs11711311 0.712 rs11718013 chr3:113341661 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.4 -8.72 -0.33 2.38e-17 IgG glycosylation; BRCA cis rs1595825 0.627 rs1435567 chr2:198748726 T/C cg19156104 chr2:198669113 PLCL1 -0.44 -8.15 -0.31 1.9e-15 Ulcerative colitis; BRCA cis rs208520 0.909 rs9453672 chr6:66991431 A/G cg07460842 chr6:66804631 NA 0.72 12.07 0.43 2.27e-30 Exhaled nitric oxide output; BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.22 -0.31 1.16e-15 Menopause (age at onset); BRCA cis rs9487051 0.872 rs6924776 chr6:109612276 A/G cg21918786 chr6:109611834 NA -0.49 -14.06 -0.49 2.49e-39 Reticulocyte fraction of red cells; BRCA cis rs4919694 0.611 rs7091462 chr10:104948615 C/T cg04362960 chr10:104952993 NT5C2 0.73 12.77 0.45 2.07e-33 Arsenic metabolism; BRCA cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.26e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs523522 0.962 rs687873 chr12:121019634 G/A cg12219531 chr12:120966889 COQ5 0.55 11.61 0.42 2.02e-28 High light scatter reticulocyte count; BRCA cis rs4642101 0.793 rs3889513 chr3:12844070 G/A cg24848339 chr3:12840334 CAND2 0.41 10.53 0.38 4.9299999999999996e-24 QRS complex (12-leadsum); BRCA cis rs6547741 1.000 rs6718128 chr2:27833752 A/G cg27432699 chr2:27873401 GPN1 -0.43 -9.1 -0.34 1.11e-18 Oral cavity cancer; BRCA cis rs9790314 0.645 rs6778254 chr3:160892792 T/C cg04691961 chr3:161091175 C3orf57 -0.35 -8.04 -0.3 4.4e-15 Morning vs. evening chronotype; BRCA cis rs769267 0.965 rs2074303 chr19:19381755 C/T cg03709012 chr19:19516395 GATAD2A 0.72 15.67 0.53 4.71e-47 Tonsillectomy; BRCA trans rs1973993 0.561 rs56142427 chr1:96992318 A/G cg10631902 chr5:14652156 NA -0.41 -10.04 -0.37 4.08e-22 Weight; BRCA cis rs7254114 0.578 rs6511727 chr19:11315817 G/T cg06870470 chr19:11315767 DOCK6 -0.39 -9.06 -0.34 1.61e-18 Immature fraction of reticulocytes; BRCA cis rs4803468 1.000 rs4803469 chr19:41922775 A/C cg09537434 chr19:41945824 ATP5SL -1.0 -23.92 -0.69 8.58e-91 Height; BRCA trans rs8002861 0.664 rs2325089 chr13:44450222 C/G cg12856521 chr11:46389249 DGKZ -0.36 -7.82 -0.3 2.18e-14 Leprosy; BRCA cis rs10504229 0.683 rs903702 chr8:58128557 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs9462846 1.000 rs2395941 chr6:42867821 G/A cg02353165 chr6:42928485 GNMT 0.49 8.61 0.32 5.54e-17 Blood protein levels; BRCA cis rs67981189 0.574 rs2526884 chr14:71367967 G/A cg15816911 chr14:71606274 NA -0.38 -8.58 -0.32 7.37e-17 Schizophrenia; BRCA cis rs8062405 1.000 rs62036626 chr16:28844284 A/G cg16576597 chr16:28551801 NUPR1 0.3 8.37 0.31 3.53e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6912958 0.559 rs242267 chr6:88061837 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.66 -14.15 -0.49 9.46e-40 Monocyte percentage of white cells; BRCA cis rs2739330 0.731 rs5751792 chr22:24401542 G/A cg25703541 chr22:24373054 LOC391322 -0.93 -24.87 -0.7 5.22e-96 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7493 0.755 rs17886036 chr7:94987727 C/A cg19678392 chr7:94953810 PON1 -0.41 -8.84 -0.33 9.41e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs514406 0.929 rs564273 chr1:53332445 G/C cg01802117 chr1:53393560 SCP2 -0.35 -7.97 -0.3 7.16e-15 Monocyte count; BRCA cis rs12477438 0.520 rs11695751 chr2:99708247 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.68 0.77 9.96e-128 Chronic sinus infection; BRCA cis rs10504229 1.000 rs67705655 chr8:58177688 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs4595586 0.545 rs1400284 chr12:39400419 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.43 0.35 7.36e-20 Morning vs. evening chronotype; BRCA cis rs9368481 0.761 rs12661756 chr6:27003483 A/G cg12292205 chr6:26970375 C6orf41 0.8 19.5 0.61 8.44e-67 Autism spectrum disorder or schizophrenia; BRCA cis rs4718428 0.705 rs28648401 chr7:66367132 T/C cg18252515 chr7:66147081 NA -0.54 -10.94 -0.4 1.15e-25 Corneal structure; BRCA cis rs1552244 0.572 rs6783705 chr3:10164783 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.45 -0.35 6.47e-20 Alzheimer's disease; BRCA cis rs12791968 0.765 rs12794751 chr11:44998769 C/G cg11846598 chr11:44996168 LOC221122 -0.47 -8.54 -0.32 1.02e-16 Inhibitory control; BRCA cis rs13256369 1.000 rs7820159 chr8:8576215 T/C cg17143192 chr8:8559678 CLDN23 0.53 10.01 0.37 5.05e-22 Obesity-related traits; BRCA cis rs9649213 0.593 rs3801256 chr7:97992095 C/G cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.43e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs698813 0.851 rs786420 chr2:44719893 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.45 8.33 0.31 5.07e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs9814567 0.896 rs6763188 chr3:134349995 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 17.83 0.58 4.99e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs56399783 0.614 rs116929101 chr7:2760325 G/A cg23627948 chr7:2760692 NA 0.53 8.61 0.32 5.63e-17 Childhood ear infection; BRCA cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg05896524 chr21:47604654 C21orf56 0.44 8.79 0.33 1.33e-17 Testicular germ cell tumor; BRCA cis rs35110281 0.511 rs2298562 chr21:45085236 A/G cg01579765 chr21:45077557 HSF2BP -0.45 -12.14 -0.43 1.11e-30 Mean corpuscular volume; BRCA cis rs709400 0.930 rs10149249 chr14:104047757 C/T cg24130564 chr14:104152367 KLC1 -0.37 -8.85 -0.33 8.63e-18 Body mass index; BRCA cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs2075371 1.000 rs1862047 chr7:133978078 G/C cg11752832 chr7:134001865 SLC35B4 0.52 13.41 0.47 2.76e-36 Mean platelet volume; BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg02951883 chr7:2050386 MAD1L1 -0.49 -11.43 -0.41 1.19e-27 Schizophrenia; BRCA cis rs40363 0.645 rs250630 chr16:3524242 C/T cg05754148 chr16:3507555 NAT15 0.37 7.84 0.3 1.86e-14 Tuberculosis; BRCA cis rs311392 1.000 rs2666871 chr8:55089184 C/T cg11783602 chr8:55087084 NA -0.33 -9.95 -0.37 8.62e-22 Pelvic organ prolapse (moderate/severe); BRCA cis rs6987853 0.787 rs2923427 chr8:42385748 A/C cg09913449 chr8:42400586 C8orf40 0.41 9.18 0.34 6.01e-19 Mean corpuscular hemoglobin concentration; BRCA trans rs61931739 0.500 rs7489270 chr12:34432062 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.57 0.35 2.32e-20 Morning vs. evening chronotype; BRCA cis rs67460515 0.563 rs13071892 chr3:160817877 A/C cg17135325 chr3:160939158 NMD3 0.42 8.07 0.3 3.54e-15 Parkinson's disease; BRCA trans rs17685 0.725 rs7795291 chr7:75725206 C/A cg19862616 chr7:65841803 NCRNA00174 0.84 27.04 0.73 6.53e-108 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs478304 0.651 rs78412025 chr11:65495696 T/C cg10518572 chr11:65560635 OVOL1 -0.28 -8.07 -0.3 3.56e-15 Acne (severe); BRCA cis rs7777484 0.534 rs2533886 chr7:2834869 C/T cg18446336 chr7:2847575 GNA12 -0.41 -10.18 -0.37 1.12e-22 Height; BRCA cis rs7586879 1.000 rs7603153 chr2:25116966 T/C cg01884057 chr2:25150051 NA 0.33 8.25 0.31 8.82e-16 Body mass index; BRCA cis rs10193935 0.901 rs7570083 chr2:42517859 G/A cg27598129 chr2:42591480 NA -0.64 -10.7 -0.39 1.12e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg08888203 chr3:10149979 C3orf24 0.67 14.07 0.49 2.42e-39 Alzheimer's disease; BRCA cis rs4820539 0.966 rs2267001 chr22:23456696 T/C cg14186256 chr22:23484241 RTDR1 0.73 21.23 0.64 4.04e-76 Bone mineral density; BRCA trans rs9325144 0.600 rs34138871 chr12:38735261 A/G cg23762105 chr12:34175262 ALG10 -0.38 -9.68 -0.36 8.87e-21 Morning vs. evening chronotype; BRCA cis rs11030122 0.702 rs17081 chr11:3987830 A/G cg18678763 chr11:4115507 RRM1 0.36 8.24 0.31 9.84e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs877529 0.967 rs139386 chr22:39530859 T/C cg12193277 chr22:39547181 CBX7 0.48 13.13 0.46 5.12e-35 Multiple myeloma; BRCA cis rs10504229 0.683 rs2318144 chr8:58114743 G/A cg20607798 chr8:58055168 NA 0.59 9.44 0.35 6.62e-20 Developmental language disorder (linguistic errors); BRCA cis rs36051895 0.589 rs62543574 chr9:5204090 A/T cg02405213 chr9:5042618 JAK2 -0.44 -8.26 -0.31 8.59e-16 Pediatric autoimmune diseases; BRCA cis rs4728302 0.534 rs6976069 chr7:133152898 T/C cg10665199 chr7:133106180 EXOC4 0.43 9.34 0.35 1.54e-19 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs3858526 0.523 rs10838750 chr11:5886246 C/T cg05234568 chr11:5960015 NA 0.42 9.11 0.34 1.03e-18 DNA methylation (variation); BRCA cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg23796481 chr11:64053134 BAD;GPR137 0.5 10.52 0.38 5.41e-24 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs7551345 0.653 rs6425717 chr1:31694103 A/G cg19084893 chr1:31688959 NA 0.48 10.08 0.37 2.78e-22 Schizophrenia; BRCA cis rs524281 0.861 rs10896085 chr11:65913832 A/T cg16950941 chr11:66035639 RAB1B -0.37 -7.95 -0.3 8.41e-15 Electroencephalogram traits; BRCA cis rs6684514 0.961 rs11264469 chr1:156276746 A/G cg16558208 chr1:156270281 VHLL 0.34 8.03 0.3 4.54e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg16325326 chr1:53192061 ZYG11B 0.69 16.99 0.56 1.11e-53 Monocyte count; BRCA cis rs6815814 0.950 rs67206233 chr4:38807853 T/C cg06935464 chr4:38784597 TLR10 0.5 8.27 0.31 7.76e-16 Breast cancer; BRCA cis rs10751667 0.600 rs7395387 chr11:1008664 G/C cg06064525 chr11:970664 AP2A2 -0.27 -7.98 -0.3 6.88e-15 Alzheimer's disease (late onset); BRCA cis rs1707322 0.721 rs4609469 chr1:46117185 C/T cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6912958 0.525 rs242262 chr6:88018057 A/C cg12350822 chr6:88032061 C6orf162;GJB7 0.41 11.7 0.42 8.82e-29 Monocyte percentage of white cells; BRCA cis rs7937682 1.000 rs7937682 chr11:111579939 C/G cg09085632 chr11:111637200 PPP2R1B -0.88 -19.94 -0.62 3.73e-69 Primary sclerosing cholangitis; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg22907277 chr7:1156413 C7orf50 0.47 10.37 0.38 2.23e-23 Longevity;Endometriosis; BRCA cis rs6500602 0.893 rs6500598 chr16:4470964 G/T cg08645402 chr16:4508243 NA 0.37 8.3 0.31 6.04e-16 Schizophrenia; BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg13628971 chr7:2884303 GNA12 0.46 9.26 0.34 3.1e-19 Height; BRCA cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.53 11.66 0.42 1.28e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2204008 0.744 rs8189486 chr12:38244968 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.0 0.56 9.05e-54 Bladder cancer; BRCA cis rs11031096 0.502 rs4910875 chr11:4047855 C/G cg18678763 chr11:4115507 RRM1 -0.35 -7.88 -0.3 1.46e-14 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs12142240 0.698 rs112089006 chr1:46812360 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs9457247 0.663 rs9457257 chr6:167440736 G/A cg07741184 chr6:167504864 NA 0.27 8.0 0.3 5.67e-15 Crohn's disease; BRCA trans rs61931739 0.500 rs6488211 chr12:34375620 A/T cg13010199 chr12:38710504 ALG10B -0.41 -8.12 -0.31 2.45e-15 Morning vs. evening chronotype; BRCA cis rs9311474 0.508 rs4687629 chr3:52615227 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.17 0.46 3.08e-35 Electroencephalogram traits; BRCA cis rs6665290 0.669 rs3795446 chr1:227180981 C/T cg10327440 chr1:227177885 CDC42BPA 1.07 36.95 0.83 9.33e-161 Myeloid white cell count; BRCA cis rs9527 0.544 rs1572578 chr10:104822431 C/G cg04362960 chr10:104952993 NT5C2 0.43 9.78 0.36 3.98e-21 Arsenic metabolism; BRCA cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs765787 0.530 rs28396110 chr15:45536909 A/G cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.16e-15 Uric acid levels; BRCA cis rs12971120 0.947 rs8083001 chr18:72165058 A/G cg27029518 chr18:72166324 CNDP2 -0.3 -8.3 -0.31 6.17e-16 Refractive error; BRCA cis rs7267979 1.000 rs4815407 chr20:25341478 G/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.11 -0.34 1.02e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6570726 0.791 rs13202312 chr6:145913093 T/G cg05347473 chr6:146136440 FBXO30 0.42 8.39 0.32 3.1e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs6479891 0.841 rs7092504 chr10:65089439 A/G cg14819942 chr15:35414228 NA -0.34 -8.37 -0.31 3.53e-16 Arthritis (juvenile idiopathic); BRCA trans rs11098499 0.874 rs7661020 chr4:120106982 T/C cg25214090 chr10:38739885 LOC399744 0.51 10.48 0.38 7.88e-24 Corneal astigmatism; BRCA cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg21248554 chr2:27665150 KRTCAP3 -0.31 -8.0 -0.3 5.99e-15 Total body bone mineral density; BRCA cis rs6089584 0.893 rs6089305 chr20:60571817 T/C cg13770153 chr20:60521292 NA -0.47 -11.17 -0.4 1.4e-26 Body mass index; BRCA cis rs6088580 0.713 rs1884669 chr20:33171287 G/A cg08999081 chr20:33150536 PIGU 0.49 14.03 0.49 3.73e-39 Glomerular filtration rate (creatinine); BRCA cis rs7811142 1.000 rs67471932 chr7:100009985 C/G cg11814155 chr7:99998594 ZCWPW1 0.48 8.7 0.33 2.76e-17 Platelet count; BRCA cis rs6750047 0.516 rs458704 chr2:38318134 G/A cg07380506 chr2:38303506 CYP1B1 0.4 9.11 0.34 1.02e-18 Cutaneous malignant melanoma;Melanoma; BRCA cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg08213375 chr14:104286397 PPP1R13B 0.51 11.23 0.41 7.99e-27 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs3770081 1.000 rs78032828 chr2:86309032 G/A cg23655155 chr2:86332777 POLR1A;PTCD3 -0.58 -8.31 -0.31 5.78e-16 Facial emotion recognition (sad faces); BRCA cis rs16858210 0.520 rs10460892 chr3:183546124 C/T cg03417191 chr3:183542750 MAP6D1 -0.68 -10.34 -0.38 2.84e-23 Menopause (age at onset); BRCA cis rs1355223 0.506 rs11032899 chr11:34870234 G/A cg11058730 chr11:34937778 PDHX;APIP -0.48 -9.42 -0.35 8.42e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs6951245 1.000 rs1881123 chr7:1084706 C/T cg04025307 chr7:1156635 C7orf50 0.59 9.36 0.35 1.33e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.590 rs36064164 chr2:26502768 C/T cg08470875 chr2:26401718 FAM59B 0.77 11.95 0.43 7.7e-30 Gut microbiome composition (summer); BRCA cis rs1005277 0.505 rs7917943 chr10:38195811 T/A cg25427524 chr10:38739819 LOC399744 0.66 16.09 0.54 3.7e-49 Extrinsic epigenetic age acceleration; BRCA trans rs3857536 0.813 rs2188589 chr6:66939570 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.45 -0.32 1.98e-16 Total body bone mineral density; BRCA cis rs7582180 0.591 rs2241810 chr2:101011877 T/C cg14675211 chr2:100938903 LONRF2 0.52 11.49 0.41 6.31e-28 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg11663144 chr21:46675770 NA -0.55 -12.94 -0.46 3.54e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9393692 0.905 rs6931391 chr6:26279235 G/C cg13736514 chr6:26305472 NA -0.35 -11.99 -0.43 4.93e-30 Educational attainment; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg16145915 chr7:1198662 ZFAND2A -0.66 -16.39 -0.54 1.18e-50 Longevity;Endometriosis; BRCA cis rs35110281 0.748 rs9981460 chr21:45030965 T/A cg04455712 chr21:45112962 RRP1B 0.41 10.52 0.38 5.4e-24 Mean corpuscular volume; BRCA cis rs6088813 1.000 rs6087703 chr20:33996433 T/C cg14752227 chr20:34000481 UQCC -0.43 -9.14 -0.34 7.97e-19 Height; BRCA cis rs6066835 1.000 rs4568007 chr20:47316575 C/G cg18078177 chr20:47281410 PREX1 0.69 8.04 0.3 4.27e-15 Multiple myeloma; BRCA cis rs2304069 0.954 rs10068537 chr5:149403193 G/A cg12661370 chr5:149340060 SLC26A2 0.54 7.9 0.3 1.2e-14 HIV-1 control; BRCA cis rs6545883 0.524 rs7561697 chr2:61519165 G/C cg15711740 chr2:61764176 XPO1 0.31 7.81 0.3 2.31e-14 Tuberculosis; BRCA cis rs3820928 1.000 rs9288617 chr2:227762815 G/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.38 -0.31 3.46e-16 Pulmonary function; BRCA cis rs7552404 0.924 rs1146574 chr1:76202671 A/G cg10523679 chr1:76189770 ACADM 0.77 18.74 0.6 8.51e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg02951883 chr7:2050386 MAD1L1 -0.54 -12.19 -0.43 7.11e-31 Bipolar disorder and schizophrenia; BRCA trans rs11098499 0.955 rs35197422 chr4:120169314 T/G cg25214090 chr10:38739885 LOC399744 0.48 10.62 0.39 2.18e-24 Corneal astigmatism; BRCA cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -9.01 -0.34 2.39e-18 Alzheimer's disease (late onset); BRCA cis rs17345786 0.861 rs11707689 chr3:101086475 A/G cg11279151 chr3:101281821 RG9MTD1 -0.5 -10.11 -0.37 2.16e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.862 rs6945775 chr7:65968974 G/A cg11764359 chr7:65958608 NA 0.77 17.23 0.56 6.13e-55 Aortic root size; BRCA cis rs3772130 0.962 rs9812137 chr3:121539103 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.92 0.4 1.39e-25 Cognitive performance; BRCA cis rs2742234 0.955 rs2075913 chr10:43622368 T/A cg02780029 chr10:43622663 RET -0.4 -9.93 -0.37 1e-21 Hirschsprung disease; BRCA cis rs6084875 0.733 rs6037959 chr20:4741723 A/G cg05143360 chr20:4741328 NA 0.36 7.91 0.3 1.15e-14 Systemic lupus erythematosus; BRCA cis rs9287719 0.967 rs12995159 chr2:10753323 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.98 -0.3 6.73e-15 Prostate cancer; BRCA cis rs10464366 0.517 rs13231075 chr7:39174806 G/T cg18850127 chr7:39170497 POU6F2 0.54 11.82 0.42 2.64e-29 IgG glycosylation; BRCA trans rs9325144 0.555 rs7977200 chr12:38713745 C/T cg23762105 chr12:34175262 ALG10 -0.4 -9.91 -0.36 1.24e-21 Morning vs. evening chronotype; BRCA cis rs4363385 0.747 rs7521181 chr1:152955223 G/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.73 -0.36 5.77e-21 Inflammatory skin disease; BRCA cis rs796364 1.000 rs1658807 chr2:200767512 C/T cg23649088 chr2:200775458 C2orf69 0.61 8.94 0.33 4.04e-18 Schizophrenia; BRCA cis rs13046373 0.508 rs2253516 chr21:31993317 C/T cg16812893 chr21:31813075 KRTAP15-1 0.37 9.3 0.35 2.13e-19 HDL cholesterol; BRCA cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg09904177 chr6:26538194 HMGN4 0.47 15.09 0.51 3.22e-44 Intelligence (multi-trait analysis); BRCA cis rs7301826 0.966 rs4759795 chr12:131300900 G/A cg11011512 chr12:131303247 STX2 0.4 9.94 0.37 9.57e-22 Plasma plasminogen activator levels; BRCA cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.51 9.89 0.36 1.54e-21 Lung cancer in ever smokers; BRCA cis rs10479542 0.544 rs10056863 chr5:179005100 G/A cg19626725 chr5:178986131 RUFY1 0.3 8.28 0.31 7.4e-16 Lung cancer; BRCA cis rs6088580 0.634 rs6059779 chr20:32950325 C/T cg06115741 chr20:33292138 TP53INP2 -0.39 -8.57 -0.32 7.57e-17 Glomerular filtration rate (creatinine); BRCA cis rs17685 0.712 rs7785025 chr7:75628101 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.39 8.79 0.33 1.34e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2806561 0.929 rs628096 chr1:23537676 C/G cg19743168 chr1:23544995 NA 0.47 11.77 0.42 4.24e-29 Height; BRCA cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg12373951 chr3:133503437 NA 0.46 11.07 0.4 3.69e-26 Iron status biomarkers; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg23131131 chr22:24373011 LOC391322 -0.35 -8.0 -0.3 5.82e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6582630 0.502 rs4379906 chr12:38295673 G/A cg13010199 chr12:38710504 ALG10B 0.42 8.83 0.33 1.03e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs10791323 0.604 rs2853116 chr11:133707063 A/G cg15485101 chr11:133734466 NA 0.41 9.82 0.36 2.66e-21 Childhood ear infection; BRCA cis rs9399135 0.967 rs9376075 chr6:135296963 A/G cg24558204 chr6:135376177 HBS1L 0.46 12.59 0.45 1.23e-32 Red blood cell count; BRCA cis rs10504229 0.906 rs113857287 chr8:58191683 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.49 -0.47 1.15e-36 Developmental language disorder (linguistic errors); BRCA cis rs7799006 0.964 rs3757440 chr7:2272936 A/G cg08027265 chr7:2291960 NA -0.4 -10.33 -0.38 3.13e-23 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs250677 1.000 rs190378 chr5:148434275 G/T cg23229984 chr5:148520753 ABLIM3 0.32 8.03 0.3 4.84e-15 Breast cancer; BRCA cis rs826838 0.809 rs11169666 chr12:39211300 T/C cg26384229 chr12:38710491 ALG10B 0.8 19.72 0.62 5.75e-68 Heart rate; BRCA cis rs6951245 0.744 rs10265736 chr7:1172465 C/T cg22907277 chr7:1156413 C7orf50 0.64 10.9 0.4 1.76e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2742234 0.541 rs10899782 chr10:43736361 A/T cg15436174 chr10:43711423 RASGEF1A 0.49 9.6 0.36 1.74e-20 Hirschsprung disease; BRCA cis rs9381040 0.610 rs717883 chr6:41045270 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.72 -0.33 2.47e-17 Alzheimer's disease (late onset); BRCA trans rs1493916 0.837 rs9952002 chr18:31414314 C/G cg15819921 chr19:927150 ARID3A -0.42 -8.35 -0.31 4.15e-16 Life satisfaction; BRCA cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 -0.46 -8.34 -0.31 4.43e-16 Mean platelet volume; BRCA cis rs7100689 0.555 rs1934146 chr10:82062121 C/A cg01528321 chr10:82214614 TSPAN14 0.79 16.67 0.55 4.64e-52 Post bronchodilator FEV1; BRCA cis rs61931739 0.534 rs1608911 chr12:34010249 T/C cg06521331 chr12:34319734 NA -0.62 -11.25 -0.41 6.25e-27 Morning vs. evening chronotype; BRCA cis rs6750047 0.932 rs11124631 chr2:38274908 A/G cg07380506 chr2:38303506 CYP1B1 -0.42 -9.72 -0.36 6.31e-21 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 16.94 0.56 1.88e-53 Platelet count; BRCA cis rs1218582 0.774 rs4845679 chr1:154861187 G/T cg03351412 chr1:154909251 PMVK 0.56 12.79 0.45 1.7e-33 Prostate cancer; BRCA cis rs6964587 1.000 rs28927678 chr7:91715662 C/T cg17063962 chr7:91808500 NA 0.54 12.3 0.44 2.26e-31 Breast cancer; BRCA cis rs7493 1.000 rs3735586 chr7:95035582 A/T cg17330251 chr7:94953956 PON1 -0.42 -8.98 -0.33 3.07e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6028335 0.610 rs12624452 chr20:37554781 G/T cg16355469 chr20:37678765 NA 0.45 8.16 0.31 1.76e-15 Alcohol and nicotine co-dependence; BRCA cis rs7103648 0.808 rs7103835 chr11:47461693 G/A cg20307385 chr11:47447363 PSMC3 0.79 18.71 0.59 1.35e-62 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2549003 0.811 rs10035166 chr5:131823927 C/T cg21138405 chr5:131827807 IRF1 -0.33 -8.18 -0.31 1.49e-15 Asthma (sex interaction); BRCA cis rs367615 0.552 rs2963024 chr5:108730773 C/T cg17395555 chr5:108820864 NA -0.3 -8.8 -0.33 1.28e-17 Colorectal cancer (SNP x SNP interaction); BRCA cis rs11955398 0.585 rs10041431 chr5:60010917 G/A cg02684056 chr5:59996105 DEPDC1B -0.37 -9.04 -0.34 1.91e-18 Intelligence (multi-trait analysis); BRCA cis rs1451375 0.794 rs11238134 chr7:50542927 A/C cg18232548 chr7:50535776 DDC -0.47 -10.87 -0.39 2.3e-25 Malaria; BRCA cis rs6121246 0.954 rs6089093 chr20:30421459 C/T cg13852791 chr20:30311386 BCL2L1 0.79 15.0 0.51 8.13e-44 Mean corpuscular hemoglobin; BRCA cis rs12477438 0.572 rs10170063 chr2:99655639 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.69 -0.53 3.55e-47 Chronic sinus infection; BRCA cis rs2637266 0.935 rs2583059 chr10:78395178 G/C cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs782590 0.902 rs782600 chr2:55848040 T/C cg18811423 chr2:55921094 PNPT1 0.71 22.36 0.66 3.18e-82 Metabolic syndrome; BRCA cis rs7618915 0.547 rs11719685 chr3:52676065 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.4 0.38 1.7e-23 Bipolar disorder; BRCA cis rs9283706 0.689 rs11956654 chr5:66318196 A/G cg11590213 chr5:66331682 MAST4 0.4 7.89 0.3 1.29e-14 Coronary artery disease; BRCA cis rs477895 0.713 rs882146 chr11:63976699 G/A cg23719950 chr11:63933701 MACROD1 -0.58 -9.52 -0.35 3.45e-20 Mean platelet volume; BRCA trans rs7647973 0.626 rs7637711 chr3:49829653 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.39 8.15 0.31 1.93e-15 Menarche (age at onset); BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.53 -0.52 2.14e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg18404041 chr3:52824283 ITIH1 -0.41 -12.07 -0.43 2.3e-30 Bipolar disorder; BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg12444411 chr7:2802554 GNA12 -0.36 -9.08 -0.34 1.37e-18 Height; BRCA cis rs36051895 0.626 rs10815149 chr9:5063701 T/C cg02405213 chr9:5042618 JAK2 -0.49 -9.47 -0.35 5.35e-20 Pediatric autoimmune diseases; BRCA cis rs7592578 0.766 rs62181052 chr2:191387858 A/G cg10560079 chr2:191398806 TMEM194B -0.77 -13.16 -0.46 3.76e-35 Diastolic blood pressure; BRCA cis rs977987 0.736 rs4888392 chr16:75412262 T/C cg03315344 chr16:75512273 CHST6 0.53 12.62 0.45 9.48e-33 Dupuytren's disease; BRCA cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg04478727 chr12:58166393 METTL1;FAM119B 0.55 11.45 0.41 9.27e-28 Multiple sclerosis; BRCA trans rs11098499 0.913 rs35271032 chr4:120156659 C/T cg25214090 chr10:38739885 LOC399744 0.5 10.93 0.4 1.35e-25 Corneal astigmatism; BRCA cis rs3818285 0.655 rs623980 chr10:111646147 C/T cg00817464 chr10:111662876 XPNPEP1 -0.43 -14.01 -0.48 4.58e-39 Superior crus of antihelix expression; BRCA cis rs10504229 0.639 rs17331850 chr8:58113538 G/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.06 -0.34 1.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs2033711 0.783 rs8113810 chr19:58932106 A/G cg00825309 chr19:58991885 ZNF446 -0.58 -12.73 -0.45 2.97e-33 Uric acid clearance; BRCA cis rs7772486 0.875 rs9390372 chr6:146363638 G/C cg23711669 chr6:146136114 FBXO30 0.69 16.02 0.54 7.97e-49 Lobe attachment (rater-scored or self-reported); BRCA cis rs881375 0.678 rs9886724 chr9:123665019 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.61 0.42 1.98e-28 Rheumatoid arthritis; BRCA cis rs17270561 0.609 rs4712970 chr6:25770707 G/A cg16482183 chr6:26056742 HIST1H1C 0.48 9.65 0.36 1.12e-20 Iron status biomarkers; BRCA cis rs10267417 0.603 rs28510133 chr7:19935487 A/T cg05791153 chr7:19748676 TWISTNB 0.41 7.82 0.3 2.21e-14 Night sleep phenotypes; BRCA cis rs4631830 0.683 rs10763193 chr10:51504938 G/A cg20129853 chr10:51489980 NA 0.31 8.55 0.32 8.74e-17 Prostate-specific antigen levels; BRCA cis rs2739330 0.828 rs5760108 chr22:24252668 G/T cg04234412 chr22:24373322 LOC391322 -0.57 -14.17 -0.49 7.46e-40 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7249142 0.549 rs539 chr19:19287802 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -11.03 -0.4 5.31e-26 IgG glycosylation; BRCA cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg14664628 chr15:75095509 CSK -0.73 -17.73 -0.57 1.73e-57 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs12540874 0.663 rs1451371 chr7:50553051 T/C cg18232548 chr7:50535776 DDC -0.55 -14.23 -0.49 4.18e-40 Systemic sclerosis; BRCA cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg10802521 chr3:52805072 NEK4 -0.34 -9.32 -0.35 1.89e-19 Bipolar disorder; BRCA cis rs1005277 0.529 rs1780125 chr10:38531376 A/G cg00409905 chr10:38381863 ZNF37A -0.53 -11.36 -0.41 2.39e-27 Extrinsic epigenetic age acceleration; BRCA trans rs9409565 0.717 rs61470662 chr9:97189472 T/C cg05679027 chr9:99775184 HIATL2 -0.42 -9.25 -0.34 3.21e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs1691799 0.867 rs1168356 chr12:66750469 A/G cg16791601 chr12:66731901 HELB -0.62 -16.42 -0.54 7.93e-51 White blood cell count (basophil); BRCA cis rs9733 0.596 rs12086630 chr1:150650955 T/C cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs910316 0.763 rs175490 chr14:75545685 A/G cg08847533 chr14:75593920 NEK9 0.81 19.35 0.61 5.21e-66 Height; BRCA cis rs9457247 1.000 rs439553 chr6:167391212 A/G cg23791538 chr6:167370224 RNASET2 -0.37 -9.17 -0.34 6.65e-19 Crohn's disease; BRCA cis rs7847628 0.550 rs12343516 chr9:123603469 A/C cg03808351 chr9:123631620 PHF19 0.61 12.43 0.44 6.19e-32 Birth weight; BRCA cis rs2019137 0.936 rs12620738 chr2:113963739 C/T cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.33 -0.47 6e-36 Lymphocyte counts; BRCA cis rs7523050 0.908 rs72697202 chr1:109398704 A/G cg08274380 chr1:109419600 GPSM2 0.82 12.5 0.44 3.02e-32 Fat distribution (HIV); BRCA cis rs2204008 0.806 rs1589382 chr12:38408565 T/A cg26384229 chr12:38710491 ALG10B 0.74 17.12 0.56 2.19e-54 Bladder cancer; BRCA cis rs832187 0.776 rs854622 chr3:63862842 C/T cg16258503 chr3:63850278 ATXN7;THOC7 -0.38 -7.82 -0.3 2.15e-14 Schizophrenia; BRCA cis rs4363385 0.720 rs9325996 chr1:152965347 A/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.56 -0.32 8.53e-17 Inflammatory skin disease; BRCA cis rs17666538 0.585 rs336444 chr8:633123 C/G cg02524346 chr8:600233 NA -0.69 -9.96 -0.37 7.91e-22 IgG glycosylation; BRCA cis rs7524258 0.868 rs2412152 chr1:7303213 C/T cg07173049 chr1:7289937 CAMTA1 0.54 13.01 0.46 1.68e-34 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs4363385 0.818 rs11205164 chr1:152986023 A/T cg25856811 chr1:152973957 SPRR3 -0.32 -8.41 -0.32 2.64e-16 Inflammatory skin disease; BRCA cis rs35306767 0.903 rs35637113 chr10:874149 G/C cg25019033 chr10:957182 NA -0.44 -8.25 -0.31 9.08e-16 Eosinophil percentage of granulocytes; BRCA cis rs870825 0.860 rs56180712 chr4:185600223 A/G cg04058563 chr4:185651563 MLF1IP 0.82 13.82 0.48 3.56e-38 Blood protein levels; BRCA cis rs189798 0.592 rs10111263 chr8:8969433 C/G cg15556689 chr8:8085844 FLJ10661 -0.4 -9.79 -0.36 3.41e-21 Myopia (pathological); BRCA cis rs1858740 0.509 rs196375 chr3:38422919 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.53 12.49 0.44 3.4e-32 Schizophrenia; BRCA cis rs4853012 0.941 rs60291089 chr2:74344890 T/G cg20891558 chr2:74357851 NA 0.51 12.11 0.43 1.53e-30 Gestational age at birth (maternal effect); BRCA cis rs4268898 0.662 rs55661701 chr2:24400769 A/C cg08917208 chr2:24149416 ATAD2B 0.53 8.36 0.31 3.99e-16 Asthma; BRCA cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg24549020 chr5:56110836 MAP3K1 -0.47 -8.4 -0.32 2.96e-16 Initial pursuit acceleration; BRCA cis rs10046574 0.561 rs17403528 chr7:135195531 C/T cg27474649 chr7:135195673 CNOT4 0.66 10.49 0.38 7.12e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg03433033 chr1:76189801 ACADM 0.57 11.59 0.42 2.44e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg22920501 chr2:26401640 FAM59B 0.89 16.29 0.54 3.91e-50 Gut microbiome composition (summer); BRCA cis rs514406 0.708 rs546334 chr1:53326210 T/C cg27535305 chr1:53392650 SCP2 -0.47 -11.4 -0.41 1.55e-27 Monocyte count; BRCA trans rs9409565 0.826 rs4612412 chr9:97208627 C/G cg05679027 chr9:99775184 HIATL2 -0.43 -9.49 -0.35 4.59e-20 Colorectal cancer (alcohol consumption interaction); BRCA cis rs10751667 0.666 rs6597966 chr11:950750 T/C cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA cis rs9283706 0.676 rs6449842 chr5:66323159 C/G cg11590213 chr5:66331682 MAST4 0.4 7.92 0.3 1.05e-14 Coronary artery disease; BRCA cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg04727924 chr7:799746 HEATR2 0.54 9.46 0.35 5.69e-20 Cerebrospinal P-tau181p levels; BRCA cis rs7582180 0.675 rs4851313 chr2:101029002 A/G cg14675211 chr2:100938903 LONRF2 -0.45 -10.2 -0.37 9.76e-23 Intelligence (multi-trait analysis); BRCA cis rs10870270 1.000 rs10870232 chr10:133738537 T/G cg08754478 chr10:133766260 PPP2R2D -0.69 -14.2 -0.49 5.8e-40 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9467773 0.620 rs2498351 chr6:26659642 C/T cg11502198 chr6:26597334 ABT1 0.56 11.97 0.43 6.47e-30 Intelligence (multi-trait analysis); BRCA cis rs6087771 0.890 rs6089056 chr20:30325773 A/G cg13852791 chr20:30311386 BCL2L1 0.96 23.39 0.68 6.61e-88 Subcortical brain region volumes;Putamen volume; BRCA cis rs10256972 0.758 rs11980081 chr7:1069372 T/C cg23978390 chr7:1156363 C7orf50 0.41 9.33 0.35 1.73e-19 Longevity;Endometriosis; BRCA cis rs2235642 0.671 rs2235641 chr16:1608177 A/G cg03034668 chr16:1723424 CRAMP1L -0.41 -9.1 -0.34 1.17e-18 Coronary artery disease; BRCA cis rs10129255 0.500 rs10143385 chr14:107190796 G/A cg07958169 chr14:107095056 NA -0.4 -8.6 -0.32 6.3e-17 Kawasaki disease; BRCA cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 -0.55 -10.68 -0.39 1.36e-24 IgG glycosylation; BRCA cis rs801193 0.967 rs1110414 chr7:66205582 A/G cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs546131 0.928 rs547504 chr11:34847225 G/T cg11058730 chr11:34937778 PDHX;APIP 0.43 8.19 0.31 1.41e-15 Lung disease severity in cystic fibrosis; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 -0.64 -13.7 -0.48 1.25e-37 Lymphocyte counts; BRCA cis rs10751667 0.643 rs7396407 chr11:929374 A/T cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA cis rs13191362 1.000 rs13191362 chr6:163033350 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.52 8.13 0.31 2.29e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2832077 0.506 rs2832093 chr21:30164855 C/T cg08807101 chr21:30365312 RNF160 -0.39 -8.12 -0.31 2.4e-15 Cognitive test performance; BRCA cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg22906224 chr7:99728672 NA 0.41 8.24 0.31 9.71e-16 Coronary artery disease; BRCA cis rs977987 0.778 rs11858992 chr16:75411445 A/C cg03315344 chr16:75512273 CHST6 0.53 12.62 0.45 9.22e-33 Dupuytren's disease; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg09263875 chr16:632152 PIGQ 0.73 21.21 0.64 5.35e-76 Height; BRCA cis rs10504073 0.584 rs74457150 chr8:49890753 C/G cg00325661 chr8:49890786 NA 0.52 15.12 0.51 2.25e-44 Blood metabolite ratios; BRCA cis rs68170813 0.559 rs77422419 chr7:106957932 A/G cg02696742 chr7:106810147 HBP1 -0.54 -8.65 -0.32 4.3e-17 Coronary artery disease; BRCA cis rs4862750 0.914 rs6814259 chr4:187872337 T/C cg10295955 chr4:187884368 NA -0.86 -24.64 -0.7 1.01e-94 Lobe attachment (rater-scored or self-reported); BRCA trans rs62103177 0.608 rs551643 chr18:77838970 C/G cg05926928 chr17:57297772 GDPD1 -0.75 -10.75 -0.39 6.98e-25 Opioid sensitivity; BRCA cis rs11112613 0.775 rs12371537 chr12:105971425 T/C cg03607813 chr12:105948248 NA 0.58 10.07 0.37 3.22e-22 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA trans rs7824557 0.734 rs2293856 chr8:11177447 C/T cg15556689 chr8:8085844 FLJ10661 0.4 9.3 0.35 2.18e-19 Retinal vascular caliber; BRCA cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg24596788 chr1:163392923 NA -0.37 -10.0 -0.37 5.49e-22 Motion sickness; BRCA cis rs7811142 0.830 rs7341507 chr7:99951315 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.53 8.36 0.31 3.87e-16 Platelet count; BRCA cis rs7772486 0.558 rs9497403 chr6:146054695 T/G cg05347473 chr6:146136440 FBXO30 -0.61 -12.02 -0.43 3.63e-30 Lobe attachment (rater-scored or self-reported); BRCA cis rs1005277 0.579 rs11011461 chr10:38431427 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -11.14 -0.4 1.81e-26 Extrinsic epigenetic age acceleration; BRCA cis rs713587 1.000 rs2384054 chr2:25156773 T/C cg01884057 chr2:25150051 NA 0.32 8.37 0.31 3.67e-16 Body mass index in non-asthmatics; BRCA cis rs6964587 1.000 rs10264666 chr7:91578639 G/A cg22117172 chr7:91764530 CYP51A1 -0.23 -7.92 -0.3 1.03e-14 Breast cancer; BRCA cis rs769267 0.930 rs892022 chr19:19613381 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.1 0.31 2.81e-15 Tonsillectomy; BRCA cis rs1862618 0.671 rs252897 chr5:56223000 G/A cg22800045 chr5:56110881 MAP3K1 0.45 8.94 0.33 4.32e-18 Initial pursuit acceleration; BRCA trans rs35110281 0.837 rs2838336 chr21:45071741 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.36 -7.81 -0.3 2.35e-14 Mean corpuscular volume; BRCA cis rs6062302 0.522 rs3787112 chr20:62222411 G/A cg16989086 chr20:62203971 PRIC285 0.52 8.96 0.33 3.43e-18 Glioblastoma; BRCA cis rs8031584 0.958 rs34909055 chr15:31284170 C/T cg14829155 chr15:31115871 NA -0.4 -9.3 -0.35 2.13e-19 Huntington's disease progression; BRCA cis rs9311474 0.508 rs11720159 chr3:52617802 T/G cg10802521 chr3:52805072 NEK4 -0.34 -9.28 -0.34 2.64e-19 Electroencephalogram traits; BRCA cis rs6964587 0.773 rs62467797 chr7:91889722 G/A cg17063962 chr7:91808500 NA 0.51 10.97 0.4 8.74e-26 Breast cancer; BRCA cis rs911555 0.723 rs4906324 chr14:103923099 A/G cg12935359 chr14:103987150 CKB 0.65 15.04 0.51 5.76e-44 Intelligence (multi-trait analysis); BRCA cis rs11690935 0.959 rs7608403 chr2:172646765 A/C cg13550731 chr2:172543902 DYNC1I2 -0.91 -31.17 -0.78 2.07e-130 Schizophrenia; BRCA cis rs6089829 0.888 rs4809468 chr20:61673566 T/C cg08045932 chr20:61659980 NA 0.47 10.39 0.38 1.86e-23 Prostate cancer (SNP x SNP interaction); BRCA cis rs7267979 1.000 rs4815424 chr20:25390284 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.3 -8.5 -0.32 1.32e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs72781680 0.898 rs55846516 chr2:24158003 T/C cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg11173246 chr11:841376 TSPAN4;POLR2L -0.33 -7.82 -0.3 2.24e-14 Mean platelet volume; BRCA cis rs427394 1.000 rs274672 chr5:6744176 G/A cg10857441 chr5:6722123 POLS -0.31 -10.49 -0.38 7.42e-24 Menopause (age at onset); BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.29 -0.38 4.54e-23 Initial pursuit acceleration; BRCA cis rs875971 0.660 rs1860468 chr7:66107252 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.62 -0.32 5.25e-17 Aortic root size; BRCA cis rs938554 0.513 rs3775946 chr4:9995256 A/G cg00071950 chr4:10020882 SLC2A9 0.4 8.48 0.32 1.61e-16 Blood metabolite levels; BRCA cis rs6087990 0.806 rs4911259 chr20:31376282 A/C cg13636640 chr20:31349939 DNMT3B 0.59 17.52 0.57 2.11e-56 Ulcerative colitis; BRCA trans rs1459104 1.000 rs17578206 chr11:55171677 T/C cg15704280 chr7:45808275 SEPT13 0.63 8.0 0.3 5.74e-15 Body mass index; BRCA cis rs1003719 0.715 rs2835646 chr21:38546574 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs9733 0.596 rs72702552 chr1:150677462 G/A cg18016565 chr1:150552671 MCL1 0.34 8.01 0.3 5.32e-15 Tonsillectomy; BRCA cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg10523679 chr1:76189770 ACADM 0.88 20.81 0.64 7.76e-74 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7072216 0.763 rs8181292 chr10:100175477 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.51 -0.35 3.76e-20 Metabolite levels; BRCA cis rs7833986 0.501 rs2667999 chr8:56950474 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.74 13.87 0.48 1.91e-38 Height; BRCA cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.88 -0.4 2.13e-25 Schizophrenia; BRCA trans rs2727020 0.521 rs10839299 chr11:49573981 C/T cg11707556 chr5:10655725 ANKRD33B -0.43 -9.6 -0.36 1.77e-20 Coronary artery disease; BRCA cis rs2153535 0.580 rs1410766 chr6:8525360 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.25 0.49 3.24e-40 Motion sickness; BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg26516362 chr5:178986906 RUFY1 -0.47 -13.86 -0.48 2.12e-38 Lung cancer; BRCA cis rs4853036 0.672 rs12988897 chr2:70028976 A/G cg02498382 chr2:70120550 SNRNP27 -0.45 -7.9 -0.3 1.21e-14 Colorectal or endometrial cancer; BRCA trans rs7824557 0.505 rs2736313 chr8:11086942 C/T cg08975724 chr8:8085496 FLJ10661 0.42 8.75 0.33 1.86e-17 Retinal vascular caliber; BRCA cis rs8017423 0.967 rs59980414 chr14:90687738 G/C cg04374321 chr14:90722782 PSMC1 0.73 19.03 0.6 2.59e-64 Mortality in heart failure; BRCA cis rs780096 0.506 rs1647285 chr2:27714511 A/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.57 -0.35 2.21e-20 Total body bone mineral density; BRCA cis rs6809651 0.524 rs79262908 chr3:185803594 C/T cg00760338 chr3:185826511 ETV5 -0.48 -9.57 -0.35 2.34e-20 Body mass index in physically active individuals;Glomerular filtration rate (creatinine);Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically inactive individuals; BRCA cis rs2731664 0.792 rs335434 chr5:176867276 A/G cg23176889 chr5:176863531 GRK6 -0.6 -15.86 -0.53 5.03e-48 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg06238570 chr21:40685208 BRWD1 -0.41 -8.49 -0.32 1.45e-16 Menarche (age at onset); BRCA cis rs4319547 0.956 rs9988963 chr12:122991478 C/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.29 -0.38 4.36e-23 Body mass index; BRCA cis rs9300255 0.679 rs12817892 chr12:123728702 G/A cg00376283 chr12:123451042 ABCB9 -0.55 -10.78 -0.39 5.09e-25 Neutrophil percentage of white cells; BRCA cis rs12926788 0.640 rs12924246 chr16:24844629 A/G cg00339695 chr16:24857497 SLC5A11 0.51 11.14 0.4 1.79e-26 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs250677 0.687 rs36043 chr5:148440983 G/A cg12140854 chr5:148520817 ABLIM3 -0.43 -9.06 -0.34 1.58e-18 Breast cancer; BRCA cis rs12586317 0.620 rs28870452 chr14:35536878 C/A cg16230307 chr14:35515116 FAM177A1 0.71 14.5 0.5 2.23e-41 Psoriasis; BRCA cis rs7917772 0.604 rs4917977 chr10:104363119 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.48 14.32 0.49 1.48e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7103648 0.864 rs12801188 chr11:47388214 G/A cg03711944 chr11:47377212 SPI1 -0.49 -12.56 -0.44 1.7e-32 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs7103648 0.669 rs10437655 chr11:47391948 G/A cg20307385 chr11:47447363 PSMC3 0.75 21.25 0.64 3.33e-76 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2882667 0.690 rs288009 chr5:138228662 G/A cg04439458 chr5:138467593 SIL1 -0.34 -8.28 -0.31 7.37e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs990171 0.607 rs1558642 chr2:102763960 T/G cg22835712 chr2:102737379 NA 0.56 9.8 0.36 3.11e-21 Lymphocyte counts; BRCA cis rs7246657 0.722 rs2927746 chr19:38156570 G/A cg23950597 chr19:37808831 NA 0.54 9.13 0.34 9.22e-19 Coronary artery calcification; BRCA cis rs6740322 0.748 rs6732337 chr2:43462822 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.76 14.79 0.51 8.61e-43 Coronary artery disease; BRCA cis rs965469 0.779 rs2236112 chr20:3294983 C/G cg25506879 chr20:3388711 C20orf194 -0.43 -8.71 -0.33 2.61e-17 IFN-related cytopenia; BRCA cis rs17818399 0.612 rs4952834 chr2:46777462 C/G cg02822958 chr2:46747628 ATP6V1E2 0.55 10.99 0.4 7.18e-26 Height; BRCA cis rs763014 0.966 rs4247097 chr16:654224 G/A cg04709771 chr16:646395 RAB40C 0.44 11.12 0.4 2.31e-26 Height; BRCA trans rs7647973 0.593 rs58339610 chr3:49845006 T/A cg21665057 chr3:196295764 WDR53;FBXO45 0.38 7.96 0.3 7.9e-15 Menarche (age at onset); BRCA cis rs4900538 0.855 rs72698597 chr14:102868633 C/T cg18135206 chr14:102964638 TECPR2 -0.92 -21.34 -0.65 1.08e-76 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs9287719 0.967 rs6750891 chr2:10738563 T/C cg00105475 chr2:10696890 NA 0.44 10.34 0.38 2.87e-23 Prostate cancer; BRCA cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.29 0.31 6.59e-16 Aortic root size; BRCA cis rs4820294 1.000 rs7291867 chr22:38062112 C/G cg21798802 chr22:38057573 PDXP 0.48 12.66 0.45 6.11e-33 Fat distribution (HIV); BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg21782813 chr7:2030301 MAD1L1 0.4 10.72 0.39 9.29e-25 Bipolar disorder and schizophrenia; BRCA cis rs6005807 0.719 rs12165715 chr22:29005595 T/C cg12565055 chr22:29076175 TTC28 0.48 8.79 0.33 1.41e-17 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs2204008 0.774 rs8189620 chr12:38241621 A/G cg26384229 chr12:38710491 ALG10B 0.75 16.9 0.56 3.07e-53 Bladder cancer; BRCA cis rs2576037 0.526 rs4890707 chr18:44497724 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.58 -11.94 -0.43 8.31e-30 Personality dimensions; BRCA cis rs897080 0.552 rs698799 chr2:44690618 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.45 0.35 6.34e-20 Height; BRCA cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg04450456 chr4:17643702 FAM184B 0.35 10.37 0.38 2.11e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs585510 1 rs585510 chr12:121000133 A/G cg27279351 chr12:120934652 DYNLL1 0.57 13.42 0.47 2.43e-36 Reticulocyte fraction of red cells; BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg21143896 chr7:2802374 GNA12 -0.31 -7.94 -0.3 8.87e-15 Height; BRCA cis rs868036 1.000 rs868036 chr15:68055013 T/A cg08079166 chr15:68083412 MAP2K5 -0.33 -8.71 -0.33 2.52e-17 Restless legs syndrome; BRCA trans rs9650657 0.538 rs11250093 chr8:10798828 C/T cg15556689 chr8:8085844 FLJ10661 0.33 8.4 0.32 2.97e-16 Neuroticism; BRCA cis rs1003719 0.788 rs4816560 chr21:38487561 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 13.91 0.48 1.26e-38 Eye color traits; BRCA cis rs7178424 0.967 rs1030859 chr15:62364932 A/G cg00456672 chr15:62358751 C2CD4A 0.34 8.03 0.3 4.6e-15 Height; BRCA cis rs4665809 1.000 rs4665823 chr2:26312723 A/G cg22920501 chr2:26401640 FAM59B -0.67 -11.53 -0.42 4.47e-28 Gut microbiome composition (summer); BRCA cis rs7618915 0.547 rs3774365 chr3:52642487 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.61 -0.45 1.03e-32 Bipolar disorder; BRCA cis rs4563143 0.675 rs73029049 chr19:29275534 C/A cg12667521 chr19:29218732 NA 0.47 8.85 0.33 8.64e-18 Methadone dose in opioid dependence; BRCA cis rs6964587 0.967 rs6465353 chr7:91779971 G/T cg17063962 chr7:91808500 NA -0.6 -14.4 -0.49 6.44e-41 Breast cancer; BRCA cis rs12477438 0.520 rs7605843 chr2:99811894 C/T cg08885076 chr2:99613938 TSGA10 0.46 10.82 0.39 3.68e-25 Chronic sinus infection; BRCA cis rs10754283 0.871 rs72712569 chr1:90125657 G/C cg21401794 chr1:90099060 LRRC8C -0.44 -9.79 -0.36 3.56e-21 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9287719 0.901 rs6432109 chr2:10736821 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs7809950 0.678 rs7790080 chr7:107031322 G/A cg23024343 chr7:107201750 COG5 -0.49 -9.73 -0.36 5.87e-21 Coronary artery disease; BRCA cis rs9815354 0.767 rs73069245 chr3:41951452 G/A cg03022575 chr3:42003672 ULK4 0.69 9.62 0.36 1.44e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs1862618 0.853 rs9283717 chr5:56078659 G/A cg24549020 chr5:56110836 MAP3K1 0.67 13.23 0.46 1.77e-35 Initial pursuit acceleration; BRCA cis rs6088813 0.961 rs3795159 chr20:33896262 C/G cg14752227 chr20:34000481 UQCC 0.4 8.38 0.31 3.28e-16 Height; BRCA trans rs9929218 0.551 rs3785134 chr16:68728938 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 30.46 0.77 1.41e-126 Colorectal cancer; BRCA cis rs7772486 0.790 rs9791313 chr6:146266172 T/C cg23711669 chr6:146136114 FBXO30 -0.67 -15.75 -0.53 1.92e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs36051895 0.623 rs12351715 chr9:5262349 A/G cg02405213 chr9:5042618 JAK2 -0.43 -8.1 -0.31 2.77e-15 Pediatric autoimmune diseases; BRCA cis rs6543140 0.890 rs61122764 chr2:102999520 A/G cg04239558 chr2:103089729 SLC9A4 0.34 9.29 0.35 2.3e-19 Blood protein levels; BRCA trans rs2727020 0.576 rs11040223 chr11:49034633 G/T cg15704280 chr7:45808275 SEPT13 -0.58 -11.74 -0.42 5.87e-29 Coronary artery disease; BRCA cis rs13118159 0.801 rs7690727 chr4:1340811 C/A cg05025164 chr4:1340916 KIAA1530 0.37 8.3 0.31 6.19e-16 Longevity; BRCA trans rs10771431 0.817 rs10843149 chr12:9362067 G/A cg27600084 chr12:12264075 NA 0.37 8.56 0.32 8.47e-17 Breast size; BRCA cis rs9368481 0.569 rs6907403 chr6:26877297 A/C cg12292205 chr6:26970375 C6orf41 0.64 14.57 0.5 9.93e-42 Autism spectrum disorder or schizophrenia; BRCA cis rs17784882 0.521 rs11713693 chr3:47074906 T/C cg16586182 chr3:47516702 SCAP 0.56 12.34 0.44 1.64e-31 QT interval; BRCA cis rs2011503 1.000 rs45631651 chr19:19638743 A/G cg11584989 chr19:19387371 SF4 0.64 13.49 0.47 1.14e-36 Bipolar disorder; BRCA cis rs7177699 0.557 rs7165075 chr15:79115965 G/A cg00540400 chr15:79124168 NA 0.27 7.81 0.3 2.44e-14 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs1003719 0.788 rs2835575 chr21:38455936 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.18 0.49 7.08e-40 Eye color traits; BRCA cis rs6005807 0.719 rs73430179 chr22:28998821 T/C cg12565055 chr22:29076175 TTC28 0.5 9.42 0.35 7.86e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg25036284 chr2:26402008 FAM59B 0.89 15.63 0.53 7.3e-47 Gut microbiome composition (summer); BRCA cis rs10911232 0.507 rs10911196 chr1:182995233 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA trans rs11039798 0.565 rs7118675 chr11:48532063 C/A cg15704280 chr7:45808275 SEPT13 0.54 9.12 0.34 9.9e-19 Axial length; BRCA cis rs2836950 0.545 rs8132143 chr21:40584258 A/T cg11890956 chr21:40555474 PSMG1 -0.65 -14.8 -0.51 7.8e-43 Menarche (age at onset); BRCA cis rs9487051 1.000 rs9386795 chr6:109616528 G/A cg01475377 chr6:109611718 NA -0.53 -13.39 -0.47 3.1e-36 Reticulocyte fraction of red cells; BRCA cis rs909002 1.000 rs909002 chr1:32139635 C/T cg13919466 chr1:32135498 COL16A1 -0.32 -10.98 -0.4 8.57e-26 Intelligence (multi-trait analysis); BRCA cis rs992157 0.835 rs7559416 chr2:219150211 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.52 -11.55 -0.42 3.64e-28 Colorectal cancer; BRCA cis rs7586879 0.593 rs6733224 chr2:25130907 C/T cg01884057 chr2:25150051 NA -0.33 -8.88 -0.33 6.59e-18 Body mass index; BRCA trans rs9951602 0.512 rs7241419 chr18:76640778 C/G cg02800362 chr5:177631904 HNRNPAB 0.76 17.64 0.57 4.82e-57 Obesity-related traits; BRCA cis rs61008539 0.893 rs7783487 chr7:860160 A/C cg00475322 chr7:917719 C7orf20 0.45 11.57 0.42 3.04e-28 Perceived unattractiveness to mosquitoes; BRCA cis rs4819052 0.851 rs13050359 chr21:46672671 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.99 0.33 2.83e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg05535760 chr7:792225 HEATR2 0.72 13.25 0.46 1.46e-35 Cerebrospinal P-tau181p levels; BRCA cis rs7618915 0.547 rs11719685 chr3:52676065 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.48 0.35 4.75e-20 Bipolar disorder; BRCA cis rs75804782 0.641 rs60841092 chr2:239349640 G/A cg18131467 chr2:239335373 ASB1 -0.63 -8.08 -0.3 3.14e-15 Morning vs. evening chronotype;Chronotype; BRCA trans rs1941687 0.510 rs1452649 chr18:31410858 A/G cg27147174 chr7:100797783 AP1S1 -0.42 -8.52 -0.32 1.17e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs1448094 0.522 rs12313658 chr12:86271063 C/T cg19622623 chr12:86230825 RASSF9 -0.32 -8.78 -0.33 1.45e-17 Major depressive disorder; BRCA cis rs754466 0.651 rs11002316 chr10:79617511 C/G cg17075019 chr10:79541650 NA -0.75 -18.1 -0.58 2.08e-59 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7772486 0.754 rs1415747 chr6:146077249 A/G cg05347473 chr6:146136440 FBXO30 0.43 8.55 0.32 9.29e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1267303 0.642 rs7542296 chr1:46998009 A/G cg25110126 chr1:46999211 NA 0.59 11.88 0.43 1.57e-29 Monobrow; BRCA cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.81e-18 Bone mineral density; BRCA cis rs473651 0.935 rs541013 chr2:239336492 G/A cg18131467 chr2:239335373 ASB1 0.96 34.72 0.81 3.22e-149 Multiple system atrophy; BRCA cis rs611744 0.647 rs2594358 chr8:109256018 A/G cg21045802 chr8:109455806 TTC35 0.35 7.87 0.3 1.54e-14 Dupuytren's disease; BRCA cis rs10256972 0.553 rs4236381 chr7:1165723 A/C cg03923535 chr7:1197113 ZFAND2A 0.52 10.53 0.38 5.31e-24 Longevity;Endometriosis; BRCA cis rs7246967 0.673 rs16999580 chr19:22923487 C/T cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs7044106 0.791 rs4836829 chr9:123482747 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.75 16.99 0.56 1.08e-53 Hip circumference adjusted for BMI; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg05863683 chr7:1912471 MAD1L1 0.44 9.84 0.36 2.29e-21 Bipolar disorder and schizophrenia; BRCA trans rs853679 0.607 rs34661125 chr6:28281894 G/A cg01620082 chr3:125678407 NA -0.84 -9.88 -0.36 1.61e-21 Depression; BRCA cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg08213375 chr14:104286397 PPP1R13B 0.64 18.41 0.59 4.97e-61 Schizophrenia; BRCA cis rs3733585 0.673 rs4627861 chr4:9954238 T/G cg11266682 chr4:10021025 SLC2A9 -0.39 -10.35 -0.38 2.53e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9399135 0.967 rs17638970 chr6:135320063 A/G cg24558204 chr6:135376177 HBS1L 0.46 12.62 0.45 8.89e-33 Red blood cell count; BRCA cis rs7301826 0.651 rs2277336 chr12:131286119 A/G cg11011512 chr12:131303247 STX2 -0.47 -11.78 -0.42 3.93e-29 Plasma plasminogen activator levels; BRCA cis rs861020 0.771 rs674804 chr1:210014603 C/G cg09163369 chr1:210001066 C1orf107 0.65 12.4 0.44 8.9e-32 Orofacial clefts; BRCA cis rs9837602 1.000 rs7627991 chr3:99808338 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.18 0.4 1.3e-26 Breast cancer; BRCA cis rs4555082 0.874 rs2816613 chr14:105726367 C/T cg27165867 chr14:105738592 BRF1 -0.35 -8.28 -0.31 6.96e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs2204008 0.714 rs11520135 chr12:38114863 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.0 0.37 5.63e-22 Bladder cancer; BRCA cis rs12586317 0.547 rs28577270 chr14:35498443 G/A cg16230307 chr14:35515116 FAM177A1 0.73 15.06 0.51 4.55e-44 Psoriasis; BRCA cis rs6062302 0.522 rs914558 chr20:62216976 A/G cg03425785 chr20:62221387 GMEB2 0.53 8.46 0.32 1.87e-16 Glioblastoma; BRCA cis rs10504229 1.000 rs66731170 chr8:58187895 C/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.755 rs76288834 chr7:66069802 G/A cg18876405 chr7:65276391 NA -0.5 -11.12 -0.4 2.15e-26 Aortic root size; BRCA cis rs7589728 0.925 rs78829281 chr2:88502293 T/A cg04511125 chr2:88470314 THNSL2 0.73 10.17 0.37 1.27e-22 Plasma clusterin levels; BRCA cis rs7811142 0.830 rs7792525 chr7:99972122 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.02 19.36 0.61 4.71e-66 Platelet count; BRCA cis rs7727544 0.904 rs6897575 chr5:131604535 C/T cg12564285 chr5:131593104 PDLIM4 0.32 8.19 0.31 1.38e-15 Blood metabolite levels; BRCA cis rs1008375 1.000 rs7697889 chr4:17617961 G/T cg02297831 chr4:17616191 MED28 0.36 8.24 0.31 9.56e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9986765 1.000 rs73725075 chr7:142823479 C/A cg15652212 chr7:142981776 TMEM139 0.56 9.29 0.34 2.37e-19 Cancer;Dermatomyositis; BRCA cis rs2297440 0.506 rs2236504 chr20:62224762 C/T cg03425785 chr20:62221387 GMEB2 0.51 8.28 0.31 7.22e-16 Glioma;Non-glioblastoma glioma;Glioblastoma; BRCA cis rs62229266 0.771 rs7277791 chr21:37383227 C/A cg12218747 chr21:37451666 NA -0.34 -8.1 -0.31 2.87e-15 Mitral valve prolapse; BRCA cis rs7552404 0.727 rs7547056 chr1:76279267 C/T cg22875332 chr1:76189707 ACADM 0.61 11.8 0.42 3.37e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2832191 0.755 rs55671430 chr21:30492421 G/C cg24692254 chr21:30365293 RNF160 -0.64 -16.62 -0.55 7.79e-52 Dental caries; BRCA cis rs13256369 1.000 rs4840352 chr8:8573508 A/G cg17143192 chr8:8559678 CLDN23 0.54 10.29 0.38 4.23e-23 Obesity-related traits; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg16606324 chr3:10149918 C3orf24 0.54 10.56 0.39 3.83e-24 Alzheimer's disease; BRCA cis rs6912958 0.678 rs9450744 chr6:88280529 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs7617773 0.817 rs9830016 chr3:48282494 A/G cg11946769 chr3:48343235 NME6 0.63 14.36 0.49 1.02e-40 Coronary artery disease; BRCA cis rs1707322 1.000 rs7526369 chr1:46390560 G/C cg03146154 chr1:46216737 IPP 0.46 10.15 0.37 1.56e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7927771 0.864 rs3781625 chr11:47443080 T/C cg20307385 chr11:47447363 PSMC3 -0.43 -9.09 -0.34 1.23e-18 Subjective well-being; BRCA cis rs7917772 0.582 rs10786682 chr10:104318322 A/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.5 -15.04 -0.51 5.27e-44 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2153535 0.580 rs9378552 chr6:8463748 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.07 0.49 2.26e-39 Motion sickness; BRCA cis rs2204008 0.543 rs2387018 chr12:38065638 C/T cg13010199 chr12:38710504 ALG10B 0.44 8.83 0.33 9.9e-18 Bladder cancer; BRCA cis rs4665809 0.589 rs4665841 chr2:26448950 G/A cg08470875 chr2:26401718 FAM59B -0.72 -12.33 -0.44 1.77e-31 Gut microbiome composition (summer); BRCA cis rs9341808 0.718 rs11962614 chr6:80823306 A/T cg08355045 chr6:80787529 NA 0.37 9.37 0.35 1.24e-19 Sitting height ratio; BRCA cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.13 -0.34 9.27e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10927875 0.541 rs1048237 chr1:16341733 T/C cg22431228 chr1:16359049 CLCNKA -0.43 -9.71 -0.36 6.72e-21 Dilated cardiomyopathy; BRCA cis rs4363385 0.818 rs678960 chr1:153011621 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs6963495 0.818 rs73190155 chr7:105153535 T/A cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1e-19 Bipolar disorder (body mass index interaction); BRCA cis rs2921073 0.605 rs2976933 chr8:8254875 A/G cg08975724 chr8:8085496 FLJ10661 0.54 11.71 0.42 7.95e-29 Parkinson's disease; BRCA cis rs4727027 0.933 rs7788925 chr7:148831621 A/G cg23583168 chr7:148888333 NA -0.78 -18.85 -0.6 2.33e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6424115 1.000 rs974698 chr1:24132785 C/T cg10978503 chr1:24200527 CNR2 0.47 12.38 0.44 1.1e-31 Immature fraction of reticulocytes; BRCA cis rs12477438 0.520 rs4850897 chr2:99768419 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.75 20.13 0.62 3.41e-70 Chronic sinus infection; BRCA cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg24531977 chr5:56204891 C5orf35 -0.88 -19.03 -0.6 2.55e-64 Initial pursuit acceleration; BRCA cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg25801113 chr15:45476975 SHF 0.31 7.82 0.3 2.22e-14 Uric acid levels; BRCA cis rs2243480 1.000 rs778704 chr7:65863467 T/C cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs12760731 0.565 rs12034657 chr1:178099354 A/C cg00404053 chr1:178313656 RASAL2 -0.63 -8.04 -0.3 4.49e-15 Obesity-related traits; BRCA cis rs11958404 0.860 rs7723564 chr5:157449396 C/T cg05962755 chr5:157440814 NA 0.59 10.79 0.39 4.96e-25 IgG glycosylation; BRCA cis rs2797160 0.967 rs2747715 chr6:126007719 A/T cg05901451 chr6:126070800 HEY2 0.39 9.49 0.35 4.49e-20 Endometrial cancer; BRCA cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg00071950 chr4:10020882 SLC2A9 0.63 16.17 0.54 1.49e-49 Bone mineral density; BRCA cis rs36051895 0.632 rs11788164 chr9:5129395 A/G cg02405213 chr9:5042618 JAK2 -0.48 -9.09 -0.34 1.2e-18 Pediatric autoimmune diseases; BRCA cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.13e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg06046430 chr4:77819534 ANKRD56 0.62 13.96 0.48 7.77e-39 Emphysema distribution in smoking; BRCA cis rs4865169 0.934 rs3796531 chr4:57850846 A/G cg16868167 chr4:57843880 C4orf14;POLR2B -0.31 -8.23 -0.31 1.07e-15 Breast cancer; BRCA cis rs10504229 0.610 rs7840469 chr8:58146992 C/T cg22535103 chr8:58192502 C8orf71 -0.41 -8.46 -0.32 1.81e-16 Developmental language disorder (linguistic errors); BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg04013093 chr6:42928303 GNMT -0.29 -8.83 -0.33 9.86e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2153535 0.580 rs1414344 chr6:8471365 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.38 0.38 2.02e-23 Motion sickness; BRCA cis rs561341 1.000 rs561341 chr17:30316385 T/G cg23018236 chr17:30244563 NA -0.62 -10.14 -0.37 1.72e-22 Hip circumference adjusted for BMI; BRCA cis rs17384381 0.953 rs12130145 chr1:85828970 G/C cg16011679 chr1:85725395 C1orf52 0.53 8.07 0.3 3.46e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs62321597 chr4:99014221 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.22e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs60871478 0.730 rs62432226 chr7:792973 T/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.54 7.87 0.3 1.54e-14 Cerebrospinal P-tau181p levels; BRCA cis rs9399135 0.684 rs1135205 chr6:135281795 C/T cg22676075 chr6:135203613 NA 0.39 7.81 0.3 2.42e-14 Red blood cell count; BRCA cis rs11971779 0.648 rs6967836 chr7:139079944 C/G cg07862535 chr7:139043722 LUC7L2 0.39 10.58 0.39 3.17e-24 Diisocyanate-induced asthma; BRCA cis rs72772090 0.539 rs72773969 chr5:96145196 C/T cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -11.86 -0.42 1.91e-29 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7635838 0.686 rs347589 chr3:11288419 A/G cg00170343 chr3:11313890 ATG7 0.43 8.4 0.32 2.92e-16 HDL cholesterol; BRCA cis rs798554 0.591 rs1182193 chr7:2869240 A/G cg09658497 chr7:2847517 GNA12 -0.41 -8.61 -0.32 5.83e-17 Height; BRCA cis rs7666738 0.830 rs10050008 chr4:99025313 T/G cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.500 rs11524949 chr12:34435551 C/T cg13010199 chr12:38710504 ALG10B 0.5 9.67 0.36 9.63e-21 Morning vs. evening chronotype; BRCA cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.59 0.32 6.78e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17490626 0.568 rs2033371 chr10:71212310 G/A cg12610070 chr10:71211762 TSPAN15 -0.31 -11.0 -0.4 6.91e-26 Thrombosis; BRCA cis rs61931739 0.500 rs34167298 chr12:34534338 G/A cg06521331 chr12:34319734 NA -0.56 -9.99 -0.37 6.47e-22 Morning vs. evening chronotype; BRCA trans rs56176327 0.600 rs7628207 chr3:49754970 T/C cg21659725 chr3:3221576 CRBN -0.48 -8.87 -0.33 7.34e-18 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs66495524 chr8:58187365 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs12618769 0.597 rs12619665 chr2:99126551 A/T cg10123293 chr2:99228465 UNC50 0.41 8.43 0.32 2.34e-16 Bipolar disorder; BRCA cis rs1862618 0.853 rs832584 chr5:56179212 A/G cg22800045 chr5:56110881 MAP3K1 -0.67 -12.48 -0.44 3.77e-32 Initial pursuit acceleration; BRCA cis rs7267979 0.966 rs6050532 chr20:25308793 A/T cg08601574 chr20:25228251 PYGB -0.35 -8.51 -0.32 1.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17345786 1.000 rs997739 chr3:101313940 A/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.47 10.86 0.39 2.59e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs559928 0.606 rs11600628 chr11:63976027 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.86 11.53 0.41 4.68e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs9470366 0.545 rs4711457 chr6:36633160 T/C cg08179530 chr6:36648295 CDKN1A -0.53 -12.06 -0.43 2.51e-30 QRS duration; BRCA cis rs849141 0.961 rs537124 chr7:28203142 C/T cg22892036 chr7:28189139 JAZF1 0.46 8.43 0.32 2.3e-16 Height;Hip circumference adjusted for BMI; BRCA cis rs7131987 0.650 rs7301188 chr12:29455391 C/T cg09582351 chr12:29534625 ERGIC2 -0.46 -10.61 -0.39 2.46e-24 QT interval; BRCA cis rs3849570 0.695 rs6804587 chr3:81873423 T/C cg07356753 chr3:81810745 GBE1 -0.4 -9.65 -0.36 1.16e-20 Waist circumference;Body mass index; BRCA cis rs6582630 0.519 rs10880576 chr12:38497693 T/C cg26384229 chr12:38710491 ALG10B 0.67 15.81 0.53 8.83e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs2832191 0.791 rs2832187 chr21:30485543 T/C cg24692254 chr21:30365293 RNF160 -0.68 -18.76 -0.6 7.17e-63 Dental caries; BRCA cis rs61931739 0.534 rs1852222 chr12:34008665 C/A cg06521331 chr12:34319734 NA -0.62 -12.18 -0.43 7.72e-31 Morning vs. evening chronotype; BRCA cis rs68170813 0.559 rs1002935 chr7:106832361 G/A cg02696742 chr7:106810147 HBP1 -0.53 -8.69 -0.33 2.93e-17 Coronary artery disease; BRCA trans rs6964833 0.935 rs13238996 chr7:74069645 A/G cg07504079 chr7:72649617 NCF1B -0.5 -9.68 -0.36 8.7e-21 Menarche (age at onset); BRCA cis rs7647973 0.922 rs57273516 chr3:49483074 A/G cg07636037 chr3:49044803 WDR6 0.76 16.5 0.55 3.36e-51 Menarche (age at onset); BRCA cis rs6088813 0.961 rs981818 chr20:33924130 C/A cg14752227 chr20:34000481 UQCC 0.41 8.61 0.32 5.48e-17 Height; BRCA cis rs72781680 1.000 rs56205282 chr2:24221317 C/T cg08917208 chr2:24149416 ATAD2B 1.08 15.0 0.51 8.89e-44 Lymphocyte counts; BRCA cis rs13118159 0.725 rs71614967 chr4:1341291 A/G cg01939980 chr4:1354348 KIAA1530 0.3 8.09 0.3 3.02e-15 Longevity; BRCA cis rs13064411 0.696 rs869343 chr3:113226705 C/T cg18753928 chr3:113234510 CCDC52 -0.58 -12.22 -0.44 5.01e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -9.43 -0.35 7.33e-20 Bipolar disorder and schizophrenia; BRCA cis rs2204008 0.775 rs12099736 chr12:38344111 C/G cg13010199 chr12:38710504 ALG10B 0.5 10.31 0.38 3.67e-23 Bladder cancer; BRCA cis rs651907 0.557 rs11711079 chr3:101386918 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.81 0.51 7.41e-43 Colorectal cancer; BRCA cis rs6121246 0.954 rs6089093 chr20:30421459 C/T cg21427119 chr20:30132790 HM13 -0.43 -9.12 -0.34 9.28e-19 Mean corpuscular hemoglobin; BRCA cis rs2839186 0.504 rs11702278 chr21:47936295 T/G cg12379764 chr21:47803548 PCNT 0.59 14.19 0.49 6.51e-40 Testicular germ cell tumor; BRCA cis rs35110281 0.633 rs2329593 chr21:45121987 T/C cg04455712 chr21:45112962 RRP1B 0.44 11.54 0.42 4.14e-28 Mean corpuscular volume; BRCA cis rs67478160 0.643 rs7156697 chr14:104211136 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -10.89 -0.4 1.88e-25 Schizophrenia; BRCA cis rs17376456 0.542 rs10476588 chr5:93208330 C/T cg25358565 chr5:93447407 FAM172A -0.68 -11.67 -0.42 1.15e-28 Diabetic retinopathy; BRCA cis rs72781680 1.000 rs7594510 chr2:24173377 A/G cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg22875332 chr1:76189707 ACADM -0.7 -14.72 -0.5 2e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs10464366 0.912 rs6979668 chr7:39104228 G/A cg15212455 chr7:39170539 POU6F2 0.36 7.87 0.3 1.48e-14 IgG glycosylation; BRCA cis rs1008375 1.000 rs4698651 chr4:17694223 A/G cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.41e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs965469 0.842 rs6051776 chr20:3332062 T/C cg25506879 chr20:3388711 C20orf194 -0.48 -9.46 -0.35 5.74e-20 IFN-related cytopenia; BRCA cis rs270601 0.633 rs733300 chr5:131572243 A/G cg18758796 chr5:131593413 PDLIM4 0.37 9.14 0.34 8.44e-19 Acylcarnitine levels; BRCA cis rs941873 0.868 rs7898 chr10:81114959 C/T cg08514558 chr10:81106712 PPIF 0.35 8.41 0.32 2.61e-16 Height; BRCA cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg21475434 chr5:93447410 FAM172A 0.67 8.87 0.33 7.36e-18 Diabetic retinopathy; BRCA cis rs10791323 0.536 rs4937842 chr11:133734542 C/G cg03690763 chr11:133734501 NA 0.29 10.28 0.38 4.76e-23 Childhood ear infection; BRCA cis rs10504229 0.683 rs7827881 chr8:58132137 C/T cg20607798 chr8:58055168 NA 0.48 8.41 0.32 2.61e-16 Developmental language disorder (linguistic errors); BRCA cis rs12586317 0.547 rs74462850 chr14:35500093 G/T cg16230307 chr14:35515116 FAM177A1 0.73 15.06 0.51 4.55e-44 Psoriasis; BRCA trans rs6479891 1.000 rs72837025 chr10:65194491 A/C cg14819942 chr15:35414228 NA 0.35 8.6 0.32 6.06e-17 Arthritis (juvenile idiopathic); BRCA cis rs758324 0.898 rs11956351 chr5:131137224 G/A cg06307176 chr5:131281290 NA 0.53 10.27 0.38 5.48e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs12681288 0.550 rs4272405 chr8:959014 C/G cg04851639 chr8:1020857 NA -0.3 -8.35 -0.31 4.29e-16 Schizophrenia; BRCA cis rs2346177 0.542 rs13024414 chr2:46687062 G/A cg02822958 chr2:46747628 ATP6V1E2 0.55 10.6 0.39 2.83e-24 HDL cholesterol; BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg08888203 chr3:10149979 C3orf24 0.65 13.64 0.47 2.35e-37 Alzheimer's disease; BRCA cis rs67981189 0.752 rs2332477 chr14:71403311 T/C cg15816911 chr14:71606274 NA -0.37 -8.23 -0.31 1.04e-15 Schizophrenia; BRCA cis rs1595825 0.891 rs57340905 chr2:198565823 C/T cg19156104 chr2:198669113 PLCL1 -0.48 -8.57 -0.32 7.75e-17 Ulcerative colitis; BRCA cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg13175981 chr1:150552382 MCL1 0.52 11.39 0.41 1.71e-27 Tonsillectomy; BRCA cis rs2404602 0.716 rs7164813 chr15:76708066 T/C cg23625390 chr15:77176239 SCAPER 0.39 9.08 0.34 1.38e-18 Blood metabolite levels; BRCA cis rs4853012 0.838 rs4452177 chr2:74345206 A/G cg19729930 chr2:74357872 NA 0.61 15.28 0.52 3.71e-45 Gestational age at birth (maternal effect); BRCA cis rs60871478 0.636 rs55663559 chr7:884057 G/A cg05535760 chr7:792225 HEATR2 -0.72 -11.36 -0.41 2.19e-27 Cerebrospinal P-tau181p levels; BRCA trans rs61931739 0.500 rs11053201 chr12:34453903 T/A cg26384229 chr12:38710491 ALG10B 0.74 16.62 0.55 8.14e-52 Morning vs. evening chronotype; BRCA cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.74 11.76 0.42 4.72e-29 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17253792 0.545 rs35466279 chr14:56017022 C/T cg01858014 chr14:56050164 KTN1 -0.61 -7.95 -0.3 8.3e-15 Putamen volume; BRCA trans rs561341 0.941 rs17780080 chr17:30343146 G/A cg20587970 chr11:113659929 NA -1.37 -24.14 -0.69 5.33e-92 Hip circumference adjusted for BMI; BRCA cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg06115741 chr20:33292138 TP53INP2 0.39 8.62 0.32 5.23e-17 Glomerular filtration rate (creatinine); BRCA cis rs73242632 1.000 rs28681160 chr4:57889166 C/T cg20415529 chr4:57845134 POLR2B;C4orf14 0.66 7.82 0.3 2.17e-14 Congenital heart disease (maternal effect); BRCA trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg21775007 chr8:11205619 TDH -0.38 -8.09 -0.3 3.07e-15 Neuroticism; BRCA cis rs4555082 0.957 rs3000073 chr14:105729792 G/A cg06808227 chr14:105710500 BRF1 -0.74 -15.2 -0.52 9.09e-45 Mean platelet volume;Platelet distribution width; BRCA cis rs6543140 0.964 rs4851010 chr2:103056127 A/T cg04239558 chr2:103089729 SLC9A4 -0.34 -9.49 -0.35 4.46e-20 Blood protein levels; BRCA cis rs7666738 0.830 rs921523 chr4:98841659 C/T cg05340658 chr4:99064831 C4orf37 0.61 14.57 0.5 1.05e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs1577917 1.000 rs12190604 chr6:86716215 G/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -13.08 -0.46 8.25e-35 Response to antipsychotic treatment; BRCA cis rs4566357 0.615 rs4675140 chr2:227908665 C/T cg05526886 chr2:227700861 RHBDD1 -0.39 -8.01 -0.3 5.46e-15 Coronary artery disease; BRCA cis rs1865760 0.786 rs2164487 chr6:25950800 A/C cg16482183 chr6:26056742 HIST1H1C 0.5 10.38 0.38 1.99e-23 Height; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.9 18.46 0.59 2.64e-61 Alzheimer's disease; BRCA cis rs1008375 0.966 rs3733581 chr4:17695206 C/G cg16339924 chr4:17578868 LAP3 -0.58 -13.83 -0.48 3.15e-38 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9649213 0.593 rs13307593 chr7:97986146 A/G cg21770322 chr7:97807741 LMTK2 0.45 11.74 0.42 5.76e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 1.000 rs2053367 chr2:26293413 T/C cg25036284 chr2:26402008 FAM59B -0.64 -10.67 -0.39 1.39e-24 Gut microbiome composition (summer); BRCA cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg10495392 chr1:46806563 NSUN4 0.46 8.31 0.31 5.61e-16 Menopause (age at onset); BRCA cis rs9469578 1.000 rs73743323 chr6:33705355 C/T cg18708504 chr6:33715942 IP6K3 0.73 10.46 0.38 9.62e-24 Phosphorus levels; BRCA cis rs4919694 1.000 rs75691516 chr10:104652045 C/T cg04362960 chr10:104952993 NT5C2 0.9 14.59 0.5 8.3e-42 Arsenic metabolism; BRCA cis rs66569888 0.632 rs6728600 chr2:106898653 G/T cg23109721 chr2:106886537 NA -0.46 -7.82 -0.3 2.15e-14 Facial morphology (factor 23); BRCA cis rs208520 1.000 rs12189683 chr6:66977716 A/C cg07460842 chr6:66804631 NA -0.88 -14.64 -0.5 4.52e-42 Exhaled nitric oxide output; BRCA trans rs6089829 0.925 rs2277767 chr20:61666937 G/A cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs3772130 0.926 rs66653099 chr3:121393089 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.53 9.02 0.34 2.13e-18 Cognitive performance; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg16145915 chr7:1198662 ZFAND2A -0.66 -17.32 -0.57 2.21e-55 Longevity;Endometriosis; BRCA cis rs6834538 1.000 rs2351761 chr4:113447911 A/G cg05166686 chr4:113558556 LARP7;C4orf21 0.41 9.13 0.34 8.76e-19 Free thyroxine concentration; BRCA cis rs10992471 0.603 rs6479422 chr9:95190694 G/T cg14631576 chr9:95140430 CENPP -0.39 -9.22 -0.34 4.34e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs6840360 0.615 rs6836249 chr4:152465829 T/G cg22705602 chr4:152727874 NA -0.32 -8.02 -0.3 5.2e-15 Intelligence (multi-trait analysis); BRCA cis rs2180341 1.000 rs2144743 chr6:127633810 A/T cg27446573 chr6:127587934 RNF146 0.9 21.36 0.65 8.49e-77 Breast cancer; BRCA cis rs12618769 0.652 rs72823794 chr2:99216593 T/A cg10123293 chr2:99228465 UNC50 0.42 8.53 0.32 1.07e-16 Bipolar disorder; BRCA cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg26248373 chr2:1572462 NA -0.62 -14.78 -0.5 1e-42 IgG glycosylation; BRCA cis rs7618915 0.547 rs2268026 chr3:52778347 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.01 0.37 5.05e-22 Bipolar disorder; BRCA cis rs4665809 1.000 rs11126375 chr2:26344787 G/A cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs9487051 0.837 rs9480920 chr6:109605322 C/A cg01475377 chr6:109611718 NA -0.59 -16.52 -0.55 2.62e-51 Reticulocyte fraction of red cells; BRCA cis rs7715811 1.000 rs67731984 chr5:13774014 G/A cg07548982 chr5:13769939 DNAH5 -0.41 -9.04 -0.34 1.79e-18 Subclinical atherosclerosis traits (other); BRCA cis rs9818758 0.505 rs67286839 chr3:49265744 C/T cg00383909 chr3:49044727 WDR6 0.77 12.98 0.46 2.39e-34 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7811142 1.000 rs1073 chr7:100031612 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 19.8 0.62 2.19e-68 Platelet count; BRCA trans rs7786808 0.564 rs10267128 chr7:158198490 G/A cg02030672 chr11:45687055 CHST1 -0.41 -9.14 -0.34 8.5e-19 Obesity-related traits; BRCA cis rs3806843 0.735 rs778596 chr5:140037272 G/A cg26395211 chr5:140044315 WDR55 0.38 8.62 0.32 5.4e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs11605275 1.000 rs73434177 chr11:20023995 G/A cg14835545 chr11:20032148 NAV2 -0.64 -9.16 -0.34 7.24e-19 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6089584 0.566 rs6061972 chr20:60610245 C/T cg13770153 chr20:60521292 NA -0.38 -8.88 -0.33 6.77e-18 Body mass index; BRCA cis rs11711311 1.000 rs9865435 chr3:113450046 G/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs4718428 0.705 rs62465692 chr7:66295745 T/C cg12165864 chr7:66369176 NA -0.44 -9.77 -0.36 4.01e-21 Corneal structure; BRCA cis rs4819052 0.851 rs2838845 chr21:46670812 A/G cg11663144 chr21:46675770 NA -0.61 -14.26 -0.49 3.03e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg08888203 chr3:10149979 C3orf24 0.64 11.9 0.43 1.24e-29 Alzheimer's disease; BRCA cis rs950169 0.580 rs2271431 chr15:85189464 A/C cg17507749 chr15:85114479 UBE2QP1 0.57 10.82 0.39 3.45e-25 Schizophrenia; BRCA cis rs2070488 0.965 rs2284819 chr3:38557161 C/T cg24069376 chr3:38537580 EXOG 0.41 11.43 0.41 1.19e-27 Electrocardiographic conduction measures; BRCA cis rs9807989 0.507 rs6755905 chr2:103048207 C/A cg03938978 chr2:103052716 IL18RAP 0.29 8.38 0.31 3.39e-16 Asthma; BRCA cis rs922182 0.967 rs17788704 chr15:64277097 A/G cg24729988 chr15:64271149 DAPK2 -0.52 -11.45 -0.41 9.64e-28 Blood protein levels; BRCA cis rs2033711 0.870 rs4801583 chr19:58918405 A/G cg13877915 chr19:58951672 ZNF132 0.45 10.73 0.39 8.17e-25 Uric acid clearance; BRCA cis rs2836974 0.627 rs9981301 chr21:40686078 G/C cg11644478 chr21:40555479 PSMG1 -0.67 -14.34 -0.49 1.22e-40 Cognitive function; BRCA cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs10504229 1.000 rs56344560 chr8:58180626 C/G cg05313129 chr8:58192883 C8orf71 -0.46 -9.67 -0.36 1.01e-20 Developmental language disorder (linguistic errors); BRCA cis rs2288073 0.965 rs6545338 chr2:24422156 C/T cg06627628 chr2:24431161 ITSN2 -0.65 -12.46 -0.44 4.49e-32 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7246657 0.943 rs3760825 chr19:37945601 C/T cg18154014 chr19:37997991 ZNF793 0.48 9.45 0.35 6.34e-20 Coronary artery calcification; BRCA cis rs7246657 0.943 rs1382357 chr19:37977609 G/A cg23950597 chr19:37808831 NA -0.62 -11.5 -0.41 6.08e-28 Coronary artery calcification; BRCA cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.6 -0.39 2.71e-24 Mean corpuscular volume; BRCA cis rs765787 0.530 rs12439643 chr15:45529767 A/G cg24006582 chr15:45444508 DUOX1 0.53 10.34 0.38 2.93e-23 Uric acid levels; BRCA cis rs17376456 0.825 rs56108532 chr5:93276342 C/T cg25358565 chr5:93447407 FAM172A 1.11 17.79 0.58 8.16e-58 Diabetic retinopathy; BRCA cis rs7267979 1.000 rs6050544 chr20:25320228 T/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.3 -0.35 2.15e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg23708337 chr7:1209742 NA 0.55 8.21 0.31 1.23e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7589728 0.925 rs80065975 chr2:88502758 G/A cg04511125 chr2:88470314 THNSL2 0.72 9.96 0.37 8.05e-22 Plasma clusterin levels; BRCA cis rs9527 0.590 rs7920868 chr10:104795409 C/T cg04362960 chr10:104952993 NT5C2 0.44 10.03 0.37 4.39e-22 Arsenic metabolism; BRCA cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg03676636 chr4:99064102 C4orf37 0.24 8.27 0.31 7.91e-16 Colonoscopy-negative controls vs population controls; BRCA trans rs208520 1.000 rs72882086 chr6:66976671 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.38 0.49 8.24e-41 Exhaled nitric oxide output; BRCA cis rs3806843 0.735 rs801188 chr5:140066916 G/T cg16179182 chr5:140090404 VTRNA1-1 0.46 10.82 0.39 3.76e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg07308232 chr7:1071921 C7orf50 -0.41 -8.39 -0.31 3.23e-16 Longevity;Endometriosis; BRCA cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg02743256 chr7:2109353 MAD1L1 -0.44 -8.18 -0.31 1.54e-15 Bipolar disorder; BRCA cis rs911555 0.519 rs8014069 chr14:104004311 A/C cg24130564 chr14:104152367 KLC1 -0.37 -8.27 -0.31 7.75e-16 Intelligence (multi-trait analysis); BRCA cis rs853679 0.517 rs868987 chr6:28110148 A/G cg18032046 chr6:28092343 ZSCAN16 0.5 8.01 0.3 5.63e-15 Depression; BRCA cis rs826838 1.000 rs11168676 chr12:38977304 A/G cg13010199 chr12:38710504 ALG10B 0.54 11.84 0.42 2.28e-29 Heart rate; BRCA cis rs6424115 0.830 rs2503002 chr1:24196957 C/G cg10978503 chr1:24200527 CNR2 0.52 13.86 0.48 2.1e-38 Immature fraction of reticulocytes; BRCA cis rs5758659 0.652 rs133301 chr22:42390093 C/T cg05082376 chr22:42548792 NA -0.32 -7.91 -0.3 1.16e-14 Cognitive function; BRCA cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 19.78 0.62 2.65e-68 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7809950 0.678 rs2237660 chr7:106862963 T/A cg23024343 chr7:107201750 COG5 -0.44 -8.88 -0.33 6.49e-18 Coronary artery disease; BRCA cis rs4891159 0.790 rs59762437 chr18:74153146 G/A cg24786174 chr18:74118243 ZNF516 -0.76 -17.92 -0.58 1.67e-58 Longevity; BRCA cis rs13256369 0.951 rs13270852 chr8:8566853 A/G cg00074818 chr8:8560427 CLDN23 0.39 8.55 0.32 9.04e-17 Obesity-related traits; BRCA cis rs4074536 0.574 rs4338353 chr1:116293646 A/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.63 -0.32 5e-17 QRS duration; BRCA cis rs372883 0.580 rs2254038 chr21:30745722 C/T cg08807101 chr21:30365312 RNF160 0.37 8.19 0.31 1.39e-15 Pancreatic cancer; BRCA trans rs9409565 0.516 rs114766729 chr9:97069901 C/T cg05679027 chr9:99775184 HIATL2 0.37 8.32 0.31 5.34e-16 Colorectal cancer (alcohol consumption interaction); BRCA cis rs11190604 0.767 rs10883484 chr10:102174803 G/C cg07080220 chr10:102295463 HIF1AN 0.49 10.0 0.37 5.91e-22 Palmitoleic acid (16:1n-7) levels; BRCA cis rs7267979 0.966 rs910996 chr20:25264196 A/G cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.42e-16 Liver enzyme levels (alkaline phosphatase); BRCA trans rs561341 1.000 rs15654 chr17:30326360 A/C cg20587970 chr11:113659929 NA -1.24 -22.67 -0.67 5.77e-84 Hip circumference adjusted for BMI; BRCA cis rs17270561 0.636 rs11794 chr6:25701718 G/A cg16482183 chr6:26056742 HIST1H1C 0.46 8.81 0.33 1.18e-17 Iron status biomarkers; BRCA trans rs7786808 0.579 rs55701656 chr7:158188812 G/A cg02030672 chr11:45687055 CHST1 0.48 10.53 0.38 4.92e-24 Obesity-related traits; BRCA trans rs11098499 0.874 rs28452522 chr4:120110784 A/G cg25214090 chr10:38739885 LOC399744 0.5 10.08 0.37 2.84e-22 Corneal astigmatism; BRCA cis rs883565 0.792 rs784490 chr3:39173530 C/T cg26331595 chr3:39149181 GORASP1;TTC21A 0.43 9.26 0.34 3.07e-19 Handedness; BRCA cis rs8180040 0.593 rs10433549 chr3:47031433 C/T cg27129171 chr3:47204927 SETD2 -0.72 -17.65 -0.57 4.35e-57 Colorectal cancer; BRCA trans rs11039798 0.660 rs28435129 chr11:48629795 A/T cg03929089 chr4:120376271 NA 0.49 8.2 0.31 1.36e-15 Axial length; BRCA cis rs733592 0.524 rs10875726 chr12:48425992 A/G cg24011408 chr12:48396354 COL2A1 -0.45 -10.12 -0.37 2.06e-22 Plateletcrit; BRCA cis rs7131987 0.934 rs7316004 chr12:29411698 C/T cg09582351 chr12:29534625 ERGIC2 -0.39 -9.37 -0.35 1.26e-19 QT interval; BRCA cis rs1865760 0.686 rs12210098 chr6:25963966 C/T cg17691542 chr6:26056736 HIST1H1C 0.55 10.74 0.39 7.25e-25 Height; BRCA cis rs290268 1.000 rs290271 chr9:93551619 G/A cg02608019 chr9:93564028 SYK 0.55 11.98 0.43 5.83e-30 Platelet count; BRCA cis rs896854 0.654 rs4735340 chr8:95976251 A/T cg16049864 chr8:95962084 TP53INP1 -0.44 -10.77 -0.39 5.57e-25 Type 2 diabetes; BRCA cis rs9815354 0.556 rs55953604 chr3:42004428 A/G cg03022575 chr3:42003672 ULK4 0.65 9.47 0.35 5.34e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs9381107 1.000 rs11754173 chr6:9455664 T/G cg14735645 chr6:9486422 NA -0.45 -7.95 -0.3 8.22e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs7811142 0.830 rs28495773 chr7:99943583 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 15.99 0.53 1.15e-48 Platelet count; BRCA cis rs11955398 0.585 rs1456743 chr5:60007421 T/A cg02684056 chr5:59996105 DEPDC1B -0.37 -9.04 -0.34 1.91e-18 Intelligence (multi-trait analysis); BRCA cis rs9462846 0.919 rs6936722 chr6:42891311 A/G cg05552183 chr6:42928497 GNMT -0.43 -8.01 -0.3 5.52e-15 Blood protein levels; BRCA cis rs8180040 0.932 rs62246474 chr3:47398130 C/T cg27129171 chr3:47204927 SETD2 -0.69 -16.54 -0.55 1.95e-51 Colorectal cancer; BRCA cis rs2404602 0.735 rs11072598 chr15:76764788 T/C cg23625390 chr15:77176239 SCAPER -0.51 -11.91 -0.43 1.08e-29 Blood metabolite levels; BRCA trans rs6089829 0.962 rs6011548 chr20:61666063 C/T cg17470723 chr8:74884337 TCEB1 0.4 8.72 0.33 2.46e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs11051970 0.611 rs56146365 chr12:32529634 A/G cg24626660 chr12:32551988 NA 0.28 8.05 0.3 4.17e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs9309473 0.687 rs6747145 chr2:73609177 C/T cg20560298 chr2:73613845 ALMS1 -0.47 -12.52 -0.44 2.64e-32 Metabolite levels; BRCA trans rs9388451 0.559 rs1777210 chr6:126098916 T/G cg05039488 chr6:79577232 IRAK1BP1 -0.53 -12.91 -0.45 4.58e-34 Brugada syndrome; BRCA cis rs35110281 0.837 rs2838336 chr21:45071741 A/G cg21573476 chr21:45109991 RRP1B 0.33 8.87 0.33 7.19e-18 Mean corpuscular volume; BRCA trans rs61931739 0.500 rs7296061 chr12:34435009 A/G cg26384229 chr12:38710491 ALG10B -0.7 -15.84 -0.53 6.87e-48 Morning vs. evening chronotype; BRCA cis rs10870270 0.956 rs10430618 chr10:133748996 C/T cg08754478 chr10:133766260 PPP2R2D -0.68 -13.79 -0.48 4.9e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs67460515 0.892 rs2054710 chr3:161090616 C/T cg03342759 chr3:160939853 NMD3 -0.72 -16.3 -0.54 3.16e-50 Parkinson's disease; BRCA cis rs2842992 0.789 rs10945635 chr6:160214487 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 17.81 0.58 6.47e-58 Age-related macular degeneration (geographic atrophy); BRCA cis rs8114671 0.562 rs8116657 chr20:33476474 C/G cg07148914 chr20:33460835 GGT7 0.46 9.76 0.36 4.67e-21 Height; BRCA cis rs11583043 0.793 rs3903905 chr1:101420957 G/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.36 0.35 1.38e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs6594713 0.756 rs6872490 chr5:112784592 T/C cg12552261 chr5:112820674 MCC 0.47 8.7 0.33 2.73e-17 Brain cytoarchitecture; BRCA cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg01262667 chr19:19385393 TM6SF2 -0.41 -10.44 -0.38 1.18e-23 Tonsillectomy; BRCA trans rs11098499 0.697 rs28655325 chr4:120372999 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.6 0.45 1.2e-32 Corneal astigmatism; BRCA cis rs586533 0.813 rs665986 chr11:99503013 A/G cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.45e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs1011018 0.628 rs7798740 chr7:139462162 T/C cg03224163 chr7:139420300 HIPK2 -0.59 -8.83 -0.33 1.01e-17 Systolic blood pressure; BRCA cis rs9291683 0.618 rs13137343 chr4:10043028 C/A cg11266682 chr4:10021025 SLC2A9 0.48 12.56 0.44 1.71e-32 Bone mineral density; BRCA cis rs10256972 0.524 rs6945202 chr7:1116558 T/C cg03188948 chr7:1209495 NA 0.47 9.18 0.34 5.7e-19 Longevity;Endometriosis; BRCA cis rs897080 0.515 rs4953088 chr2:44564518 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.57 -10.57 -0.39 3.64e-24 Height; BRCA cis rs2762353 0.902 rs1165199 chr6:25809087 C/T cg12310025 chr6:25882481 NA -0.51 -12.16 -0.43 9.04e-31 Blood metabolite levels; BRCA trans rs3733585 0.753 rs1122141 chr4:9947278 T/C cg26043149 chr18:55253948 FECH -0.41 -9.06 -0.34 1.6e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.3 0.49 2.01e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7178424 0.967 rs893156 chr15:62378892 G/A cg00456672 chr15:62358751 C2CD4A -0.36 -8.23 -0.31 1.05e-15 Height; BRCA cis rs8180040 0.966 rs12486969 chr3:47429003 G/C cg27129171 chr3:47204927 SETD2 -0.69 -16.28 -0.54 4.01e-50 Colorectal cancer; BRCA cis rs17270561 0.583 rs12662869 chr6:25784481 A/C cg17691542 chr6:26056736 HIST1H1C -0.46 -9.62 -0.36 1.52e-20 Iron status biomarkers; BRCA cis rs2204008 0.775 rs12369238 chr12:38176051 A/G cg13010199 chr12:38710504 ALG10B 0.41 8.36 0.31 3.82e-16 Bladder cancer; BRCA trans rs2204008 0.743 rs11495614 chr12:38156358 C/T cg06521331 chr12:34319734 NA -0.53 -9.31 -0.35 2.06e-19 Bladder cancer; BRCA cis rs875971 1.000 rs778694 chr7:65871558 A/G cg18876405 chr7:65276391 NA 0.55 13.35 0.47 4.99e-36 Aortic root size; BRCA cis rs17253792 0.915 rs77161327 chr14:56178565 A/G cg01858014 chr14:56050164 KTN1 -0.67 -8.24 -0.31 9.82e-16 Putamen volume; BRCA cis rs4919087 1.000 rs7067835 chr10:99074649 T/C cg25902810 chr10:99078978 FRAT1 0.52 11.25 0.41 6.4e-27 Monocyte count; BRCA cis rs6064559 0.685 rs1062601 chr20:56137834 A/G cg16101800 chr20:56136569 PCK1 -0.47 -12.34 -0.44 1.63e-31 Hemoglobin concentration; BRCA cis rs1691799 0.899 rs1168304 chr12:66738667 A/C cg16791601 chr12:66731901 HELB -0.64 -17.29 -0.56 3.01e-55 White blood cell count (basophil); BRCA cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg00071950 chr4:10020882 SLC2A9 0.54 13.1 0.46 6.59e-35 Bone mineral density; BRCA cis rs2549003 1.000 rs10214312 chr5:131821866 T/G cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA cis rs807669 0.525 rs2282684 chr22:19184244 C/T cg02655711 chr22:19163373 SLC25A1 0.45 10.12 0.37 1.95e-22 Metabolite levels; BRCA cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 1.000 rs13190742 chr6:163008758 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg14061069 chr19:46274453 DMPK -0.49 -12.19 -0.43 6.82e-31 Coronary artery disease; BRCA cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs2204008 0.744 rs11181337 chr12:38322083 C/A cg26384229 chr12:38710491 ALG10B 0.65 15.74 0.53 2.09e-47 Bladder cancer; BRCA cis rs9359856 0.564 rs6914142 chr6:90398903 C/T cg13799429 chr6:90582589 CASP8AP2 -0.66 -8.09 -0.3 2.99e-15 Bipolar disorder; BRCA cis rs7666738 0.753 rs13111199 chr4:98953705 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs9325144 0.647 rs61931899 chr12:38892422 A/G cg26384229 chr12:38710491 ALG10B -0.51 -12.38 -0.44 1.09e-31 Morning vs. evening chronotype; BRCA cis rs7091068 0.518 rs1409337 chr10:95439822 T/C cg20715218 chr10:95462985 C10orf4 0.47 9.94 0.37 9.77e-22 Urinary tract infection frequency; BRCA cis rs6840360 1.000 rs6535819 chr4:152651503 A/G cg22705602 chr4:152727874 NA -0.31 -7.92 -0.3 1.05e-14 Intelligence (multi-trait analysis); BRCA cis rs6973256 0.865 rs62470059 chr7:133334195 T/C cg07491979 chr7:133331646 EXOC4 -0.39 -8.87 -0.33 7.49e-18 Intelligence (multi-trait analysis); BRCA cis rs17401966 0.522 rs4845930 chr1:10319049 G/A cg03954927 chr1:10346856 KIF1B 0.34 10.21 0.37 8.96e-23 Hepatocellular carcinoma; BRCA cis rs10504229 0.906 rs113745779 chr8:58191301 C/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.45 -0.44 5.34e-32 Developmental language disorder (linguistic errors); BRCA cis rs6963495 0.674 rs75880756 chr7:105163821 G/C cg19920283 chr7:105172520 RINT1 0.58 9.33 0.35 1.72e-19 Bipolar disorder (body mass index interaction); BRCA cis rs17270561 1.000 rs17270561 chr6:25820439 A/C cg16482183 chr6:26056742 HIST1H1C -0.66 -11.77 -0.42 4.57e-29 Iron status biomarkers; BRCA cis rs9649213 0.593 rs6975156 chr7:97925534 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.6 -0.32 6.33e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7635838 0.686 rs347588 chr3:11287504 C/T cg00170343 chr3:11313890 ATG7 0.43 8.49 0.32 1.43e-16 HDL cholesterol; BRCA cis rs2762353 0.808 rs1165176 chr6:25830298 A/G cg03264133 chr6:25882463 NA -0.53 -11.99 -0.43 4.97e-30 Blood metabolite levels; BRCA cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg02503808 chr4:7069936 GRPEL1 0.79 18.31 0.59 1.66e-60 Monocyte percentage of white cells; BRCA cis rs7537052 0.669 rs4652903 chr1:36642858 C/T cg24686825 chr1:36642396 MAP7D1 -0.53 -12.07 -0.43 2.35e-30 Schizophrenia; BRCA trans rs61931739 0.534 rs10844732 chr12:34037104 A/C cg13010199 chr12:38710504 ALG10B 0.49 9.48 0.35 4.85e-20 Morning vs. evening chronotype; BRCA cis rs801193 0.548 rs7805152 chr7:66209253 C/T cg11764359 chr7:65958608 NA 0.75 16.78 0.55 1.26e-52 Aortic root size; BRCA cis rs896854 0.738 rs527234 chr8:95963798 C/G cg16049864 chr8:95962084 TP53INP1 0.48 10.9 0.4 1.68e-25 Type 2 diabetes; BRCA cis rs7811142 0.779 rs28680963 chr7:99905475 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.77 -12.14 -0.43 1.13e-30 Platelet count; BRCA cis rs4927850 0.501 rs9881504 chr3:195656614 A/G cg01181863 chr3:195395398 SDHAP2 -0.5 -8.37 -0.31 3.64e-16 Pancreatic cancer; BRCA cis rs875971 0.508 rs10258739 chr7:66062935 A/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.56 -0.32 8.69e-17 Aortic root size; BRCA cis rs6163 0.727 rs284854 chr10:104574562 T/G cg04362960 chr10:104952993 NT5C2 -0.34 -8.01 -0.3 5.26e-15 Waist circumference;Hip circumference; BRCA cis rs9399137 0.507 rs13209780 chr6:135344795 G/C cg24558204 chr6:135376177 HBS1L 0.59 15.82 0.53 8.45e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA trans rs12310956 0.532 rs10506119 chr12:33963684 A/G cg26384229 chr12:38710491 ALG10B 0.66 13.95 0.48 8.57e-39 Morning vs. evening chronotype; BRCA cis rs12142240 0.698 rs72890727 chr1:46860237 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs7666738 0.830 rs10021709 chr4:99030587 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs11786523 chr8:58131319 G/C cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg03433033 chr1:76189801 ACADM 0.71 14.08 0.49 2.02e-39 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7267979 1.000 rs6083813 chr20:25337671 A/G cg08601574 chr20:25228251 PYGB -0.34 -8.18 -0.31 1.58e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6952809 0.516 rs6952959 chr7:2440722 C/T cg23289794 chr7:2394357 EIF3B -0.64 -11.99 -0.43 5.32e-30 Multiple sclerosis; BRCA trans rs9329221 0.537 rs6983332 chr8:9977918 A/G cg15556689 chr8:8085844 FLJ10661 -0.33 -8.95 -0.33 3.94e-18 Neuroticism; BRCA trans rs11039798 0.588 rs11039855 chr11:48610091 A/G cg15704280 chr7:45808275 SEPT13 0.53 8.9 0.33 5.69e-18 Axial length; BRCA cis rs6121246 0.633 rs6060986 chr20:30426297 G/A cg21427119 chr20:30132790 HM13 -0.36 -8.18 -0.31 1.49e-15 Mean corpuscular hemoglobin; BRCA cis rs7914558 1.000 rs7914558 chr10:104775908 G/A cg04362960 chr10:104952993 NT5C2 0.43 10.51 0.38 6.22e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs9790314 0.875 rs336580 chr3:161082982 A/T cg04691961 chr3:161091175 C3orf57 -0.58 -15.15 -0.51 1.58e-44 Morning vs. evening chronotype; BRCA cis rs7127900 0.583 rs11043142 chr11:2234042 A/G cg25635251 chr11:2234043 NA 0.46 12.42 0.44 6.99e-32 Prostate cancer;Prostate cancer (SNP x SNP interaction);Prostate cancer (early onset); BRCA cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 8.06 0.3 3.82e-15 Tonsillectomy; BRCA cis rs7666738 0.962 rs11932892 chr4:99072967 C/T cg03676636 chr4:99064102 C4orf37 0.25 8.42 0.32 2.46e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs858239 1.000 rs199348 chr7:23293098 C/A cg23682824 chr7:23144976 KLHL7 0.33 8.42 0.32 2.4e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs11098499 0.569 rs55845118 chr4:120290913 T/C cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg18402987 chr7:1209562 NA 0.48 9.19 0.34 5.29e-19 Longevity;Endometriosis; BRCA cis rs8048589 0.558 rs34565142 chr16:12231347 C/T cg02910054 chr16:12241554 SNX29 0.39 7.83 0.3 2.02e-14 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); BRCA trans rs9951602 0.512 rs61021837 chr18:76648210 A/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.06 0.58 3.34e-59 Obesity-related traits; BRCA cis rs10910092 1 rs10910092 chr1:2501516 A/G cg18854424 chr1:2615690 NA 0.31 7.97 0.3 7.13e-15 Ulcerative colitis; BRCA cis rs8177179 0.967 rs6439436 chr3:133453779 C/T cg24879335 chr3:133465180 TF -0.33 -11.38 -0.41 1.82e-27 Iron status biomarkers (transferrin levels); BRCA cis rs6445967 0.530 rs12490706 chr3:58408247 C/T cg23715586 chr3:58305044 RPP14 -0.36 -7.89 -0.3 1.34e-14 Platelet count; BRCA cis rs35110281 0.776 rs62226866 chr21:45024186 T/C cg01579765 chr21:45077557 HSF2BP -0.44 -12.06 -0.43 2.55e-30 Mean corpuscular volume; BRCA cis rs7267979 1.000 rs6083813 chr20:25337671 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.28 -0.34 2.6e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6964587 0.869 rs7812219 chr7:91545727 C/T cg17063962 chr7:91808500 NA -0.51 -11.72 -0.42 7.25e-29 Breast cancer; BRCA cis rs6684514 1.000 rs12142808 chr1:156230546 G/A cg16558208 chr1:156270281 VHLL 0.37 8.18 0.31 1.53e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs9467773 0.873 rs9295698 chr6:26566099 T/A cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.25e-20 Intelligence (multi-trait analysis); BRCA cis rs6815814 0.950 rs5743557 chr4:38806827 G/A cg06935464 chr4:38784597 TLR10 0.51 8.42 0.32 2.52e-16 Breast cancer; BRCA cis rs739401 0.869 rs395188 chr11:3072631 A/G cg08508325 chr11:3079039 CARS 0.38 13.43 0.47 2.16e-36 Longevity; BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs875971 0.545 rs316306 chr7:65618674 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.52 -9.95 -0.37 8.93e-22 Aortic root size; BRCA cis rs9329289 0.510 rs12356215 chr10:2545390 C/G cg15501526 chr10:2543763 NA 0.47 10.83 0.39 3.3e-25 Age-related hearing impairment; BRCA cis rs13046373 0.535 rs1395775 chr21:32025065 G/A cg16812893 chr21:31813075 KRTAP15-1 0.37 9.26 0.34 3.07e-19 HDL cholesterol; BRCA cis rs250677 0.958 rs43147 chr5:148417103 C/G cg12140854 chr5:148520817 ABLIM3 0.42 8.87 0.33 7.44e-18 Breast cancer; BRCA cis rs7385804 0.796 rs221799 chr7:100288545 G/A cg20848291 chr7:100343083 ZAN 0.36 8.13 0.31 2.17e-15 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg04944784 chr2:26401820 FAM59B -0.85 -13.17 -0.46 3.18e-35 Gut microbiome composition (summer); BRCA trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg27661571 chr11:113659931 NA -0.83 -12.37 -0.44 1.19e-31 Hip circumference adjusted for BMI; BRCA trans rs7819412 0.749 rs11991118 chr8:10939273 A/C cg06636001 chr8:8085503 FLJ10661 0.49 10.07 0.37 2.99e-22 Triglycerides; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg09033563 chr22:24373618 LOC391322 0.5 10.71 0.39 9.93e-25 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs11764590 0.715 rs11766468 chr7:2082604 G/A cg23422044 chr7:1970798 MAD1L1 -0.56 -9.32 -0.35 1.85e-19 Neuroticism; BRCA cis rs1568889 1.000 rs6484346 chr11:28040767 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.84 0.51 5.04e-43 Bipolar disorder; BRCA cis rs9858542 0.537 rs9864406 chr3:49352619 A/G cg00383909 chr3:49044727 WDR6 0.43 9.37 0.35 1.22e-19 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs875971 0.516 rs6945322 chr7:65336056 T/C cg18876405 chr7:65276391 NA 0.7 18.69 0.59 1.72e-62 Aortic root size; BRCA cis rs10464366 0.544 rs1525799 chr7:39153131 C/G cg15212455 chr7:39170539 POU6F2 -0.4 -9.21 -0.34 4.56e-19 IgG glycosylation; BRCA cis rs6597981 0.592 rs10902218 chr11:743813 C/T cg01741372 chr11:783889 NA -0.46 -11.14 -0.4 1.81e-26 Breast cancer; BRCA cis rs4595586 0.545 rs4438082 chr12:39363870 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.27 0.34 2.71e-19 Morning vs. evening chronotype; BRCA cis rs9341808 0.718 rs10943696 chr6:80901272 C/G cg08355045 chr6:80787529 NA 0.39 9.96 0.37 7.9e-22 Sitting height ratio; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.89 16.33 0.54 2.46e-50 Platelet count; BRCA trans rs2797160 1.000 rs2797161 chr6:126010789 A/G cg05039488 chr6:79577232 IRAK1BP1 0.35 8.01 0.3 5.47e-15 Endometrial cancer; BRCA cis rs10779751 0.770 rs12075896 chr1:11200350 C/A cg08854313 chr1:11322531 MTOR -0.73 -14.46 -0.5 3.45e-41 Body mass index; BRCA cis rs4660306 0.961 rs2152077 chr1:45986670 G/T cg24296786 chr1:45957014 TESK2 0.43 9.15 0.34 7.54e-19 Homocysteine levels; BRCA cis rs13191362 0.872 rs73020362 chr6:163005737 A/C cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.09 0.46 7.48e-35 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.84 15.26 0.52 4.71e-45 Platelet count; BRCA cis rs684232 0.835 rs1833459 chr17:562244 C/T cg15660573 chr17:549704 VPS53 -0.37 -7.86 -0.3 1.65e-14 Prostate cancer; BRCA cis rs2011503 1.000 rs77616520 chr19:19652776 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs704795 0.902 rs11887784 chr2:27679919 A/G cg22903471 chr2:27725779 GCKR -0.36 -8.69 -0.32 3.15e-17 Menopause (age at onset); BRCA cis rs3916 0.794 rs10431384 chr12:121127347 C/T cg21892295 chr12:121157589 UNC119B 0.36 10.52 0.38 5.4e-24 Urinary metabolites (H-NMR features); BRCA cis rs35110281 0.774 rs2838327 chr21:45018566 A/C cg01579765 chr21:45077557 HSF2BP -0.4 -10.84 -0.39 2.94e-25 Mean corpuscular volume; BRCA cis rs698833 0.926 rs1065786 chr2:44660616 G/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.49 -9.87 -0.36 1.78e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs911555 0.755 rs2756122 chr14:103983033 C/G cg12935359 chr14:103987150 CKB -0.55 -12.26 -0.44 3.6e-31 Intelligence (multi-trait analysis); BRCA cis rs2559856 0.904 rs2695283 chr12:102089391 G/C cg12213457 chr12:102090980 CHPT1 -0.36 -7.81 -0.3 2.32e-14 Blood protein levels; BRCA cis rs921968 0.541 rs523305 chr2:219402691 T/C cg02176678 chr2:219576539 TTLL4 0.46 11.92 0.43 9.84e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs7246657 0.663 rs4803287 chr19:38079435 A/G cg23950597 chr19:37808831 NA -0.49 -8.35 -0.31 4.23e-16 Coronary artery calcification; BRCA cis rs9325144 0.600 rs1817648 chr12:38733424 C/T cg26384229 chr12:38710491 ALG10B -0.47 -12.17 -0.43 8.34e-31 Morning vs. evening chronotype; BRCA cis rs1862618 0.802 rs194058 chr5:56188977 G/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.38 -0.38 1.93e-23 Initial pursuit acceleration; BRCA trans rs5756813 0.635 rs6000899 chr22:38203796 C/T cg19894588 chr14:64061835 NA -0.55 -11.56 -0.42 3.43e-28 Optic cup area;Vertical cup-disc ratio; BRCA cis rs1552244 1.000 rs7651058 chr3:10066964 C/T cg00149659 chr3:10157352 C3orf10 0.71 12.26 0.44 3.67e-31 Alzheimer's disease; BRCA cis rs701145 0.585 rs1727893 chr3:153849866 A/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA trans rs3780486 0.757 rs10813949 chr9:33123464 G/A cg20290983 chr6:43655470 MRPS18A 1.12 41.79 0.86 5.88e-185 IgG glycosylation; BRCA cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.531 rs34081866 chr2:26475940 C/T cg26314531 chr2:26401878 FAM59B 0.9 16.24 0.54 6.54e-50 Gut microbiome composition (summer); BRCA cis rs6546550 0.743 rs6731941 chr2:70018496 A/G cg02498382 chr2:70120550 SNRNP27 -0.42 -8.58 -0.32 7.41e-17 Prevalent atrial fibrillation; BRCA cis rs7246657 0.943 rs10422967 chr19:37850137 T/C cg23950597 chr19:37808831 NA -0.72 -12.52 -0.44 2.58e-32 Coronary artery calcification; BRCA cis rs7772486 0.641 rs67882056 chr6:146416301 T/C cg13319975 chr6:146136371 FBXO30 -0.55 -11.88 -0.43 1.49e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs6964587 0.626 rs404 chr7:91544316 G/T cg17063962 chr7:91808500 NA -0.54 -12.45 -0.44 5.37e-32 Breast cancer; BRCA cis rs698833 0.852 rs698823 chr2:44720947 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.43 8.89 0.33 6.27e-18 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2011503 1.000 rs34067609 chr19:19653524 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.12 -0.34 1e-18 Bipolar disorder; BRCA cis rs12477438 0.520 rs13022329 chr2:99731189 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.08 0.74 1.26e-113 Chronic sinus infection; BRCA cis rs1862618 0.853 rs866222 chr5:56184444 T/C cg24549020 chr5:56110836 MAP3K1 0.64 12.87 0.45 7.13e-34 Initial pursuit acceleration; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg26119090 chr2:26468346 HADHA;HADHB 1.04 21.27 0.64 2.69e-76 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg05313129 chr8:58192883 C8orf71 -0.46 -9.48 -0.35 4.96e-20 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.517 rs7958755 chr12:34294699 T/C cg26384229 chr12:38710491 ALG10B 0.67 14.25 0.49 3.21e-40 Morning vs. evening chronotype; BRCA cis rs2625529 0.730 rs7403191 chr15:72160964 C/T cg16672083 chr15:72433130 SENP8 -0.72 -16.92 -0.56 2.49e-53 Red blood cell count; BRCA cis rs35306767 0.761 rs11253560 chr10:1047226 T/G cg20503657 chr10:835505 NA 0.95 14.44 0.5 4.23e-41 Eosinophil percentage of granulocytes; BRCA cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg09469691 chr10:81107165 PPIF 0.51 10.61 0.39 2.54e-24 Height; BRCA cis rs7618915 0.571 rs6805539 chr3:52609710 T/A cg18404041 chr3:52824283 ITIH1 -0.41 -12.06 -0.43 2.43e-30 Bipolar disorder; BRCA cis rs10876993 0.890 rs2640630 chr12:58067267 T/C cg18357645 chr12:58087776 OS9 0.47 13.55 0.47 5.98e-37 Celiac disease or Rheumatoid arthritis; BRCA cis rs425277 0.585 rs3107157 chr1:2061969 A/G cg04315214 chr1:2043799 PRKCZ 0.58 16.45 0.55 5.83e-51 Height; BRCA cis rs1215050 0.740 rs2555390 chr4:98999112 A/G cg05340658 chr4:99064831 C4orf37 -0.48 -11.18 -0.4 1.29e-26 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs1945213 0.694 rs7122627 chr11:55862565 A/G cg03929089 chr4:120376271 NA 0.61 10.56 0.39 3.97e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg08067268 chr2:26466485 HADHB;HADHA -0.58 -10.31 -0.38 3.8e-23 Gut microbiome composition (summer); BRCA cis rs7809950 1.000 rs4727680 chr7:107087407 T/G cg23024343 chr7:107201750 COG5 -0.4 -9.28 -0.34 2.65e-19 Coronary artery disease; BRCA cis rs7011049 1.000 rs72640848 chr8:53836225 A/G cg26025543 chr8:53854495 NA 0.54 9.68 0.36 8.84e-21 Systolic blood pressure; BRCA cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.45 8.07 0.3 3.37e-15 Schizophrenia; BRCA cis rs13046373 0.535 rs8129571 chr21:31980646 G/A cg06468780 chr21:31798236 KRTAP13-3 0.36 8.9 0.33 5.59e-18 HDL cholesterol; BRCA cis rs1865760 0.713 rs2013063 chr6:25994098 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.59 0.39 2.96e-24 Height; BRCA cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.91 0.74 1.14e-112 Chronic sinus infection; BRCA cis rs3767633 0.925 rs2499855 chr1:161929761 C/T cg09175582 chr1:161736000 ATF6 0.54 8.74 0.33 1.98e-17 IgG glycosylation; BRCA cis rs4713118 0.824 rs9468225 chr6:27745719 T/G cg20933634 chr6:27740509 NA 0.48 9.62 0.36 1.49e-20 Parkinson's disease; BRCA cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs12477438 0.798 rs13412764 chr2:99583733 G/A cg08885076 chr2:99613938 TSGA10 -0.6 -13.44 -0.47 1.91e-36 Chronic sinus infection; BRCA cis rs7264396 0.690 rs2425171 chr20:34443173 G/C cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.13 0.31 2.28e-15 Total cholesterol levels; BRCA cis rs2645694 0.626 rs2703121 chr4:77822328 C/G cg06046430 chr4:77819534 ANKRD56 0.61 13.69 0.48 1.39e-37 Emphysema distribution in smoking; BRCA cis rs12545109 0.800 rs1467125 chr8:57418638 C/T cg09654669 chr8:57350985 NA -0.42 -8.22 -0.31 1.15e-15 Obesity-related traits; BRCA cis rs7666738 0.830 rs6851253 chr4:99029980 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 1.000 rs1600209 chr3:161038217 A/T cg04691961 chr3:161091175 C3orf57 -0.59 -13.97 -0.48 7.07e-39 Morning vs. evening chronotype; BRCA cis rs2204008 0.702 rs3849999 chr12:38483498 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.84 -0.36 2.21e-21 Bladder cancer; BRCA cis rs425277 0.628 rs262662 chr1:2085033 A/G cg19257562 chr1:2043853 PRKCZ -0.34 -9.07 -0.34 1.46e-18 Height; BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26314531 chr2:26401878 FAM59B -0.65 -11.11 -0.4 2.38e-26 Gut microbiome composition (summer); BRCA cis rs10870270 0.917 rs9971362 chr10:133790150 T/C cg08754478 chr10:133766260 PPP2R2D -0.68 -13.37 -0.47 4.13e-36 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4803468 1.000 rs10409485 chr19:41920765 C/T cg09537434 chr19:41945824 ATP5SL 1.0 23.79 0.69 4.53e-90 Height; BRCA cis rs10504229 0.815 rs75577263 chr8:58188434 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.54 -0.47 6.75e-37 Developmental language disorder (linguistic errors); BRCA cis rs6500602 0.592 rs7206782 chr16:4515145 A/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.36 7.87 0.3 1.49e-14 Schizophrenia; BRCA cis rs6442522 0.733 rs4143273 chr3:15501808 C/T cg16303742 chr3:15540471 COLQ -0.33 -7.84 -0.3 1.91e-14 Uric acid levels; BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg22920501 chr2:26401640 FAM59B -0.94 -16.36 -0.54 1.65e-50 Gut microbiome composition (summer); BRCA trans rs61931739 0.500 rs12146843 chr12:34451738 T/G cg13010199 chr12:38710504 ALG10B 0.42 9.03 0.34 2.09e-18 Morning vs. evening chronotype; BRCA cis rs4889855 0.505 rs12952775 chr17:78607820 A/G cg16591659 chr17:78472290 NA -0.31 -8.0 -0.3 5.96e-15 Fractional excretion of uric acid; BRCA cis rs13108904 0.870 rs3755927 chr4:1238246 G/A cg05665937 chr4:1216051 CTBP1 0.38 7.99 0.3 6.33e-15 Obesity-related traits; BRCA cis rs7949030 0.626 rs11231144 chr11:62328038 A/G cg22862634 chr11:62369728 EML3;MTA2 0.56 13.75 0.48 7.52e-38 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2072499 0.750 rs57056972 chr1:156159064 C/A cg24450063 chr1:156163899 SLC25A44 0.94 18.49 0.59 1.82e-61 Testicular germ cell tumor; BRCA trans rs7819412 0.691 rs73198970 chr8:11040216 T/C cg15556689 chr8:8085844 FLJ10661 -0.32 -8.28 -0.31 7.29e-16 Triglycerides; BRCA cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg18964960 chr10:1102726 WDR37 0.63 8.77 0.33 1.62e-17 Eosinophil percentage of granulocytes; BRCA cis rs10883723 0.669 rs2001595 chr10:104395085 C/T cg22532475 chr10:104410764 TRIM8 -0.32 -8.01 -0.3 5.28e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.6 -0.32 6.05e-17 Total body bone mineral density; BRCA cis rs9814567 0.574 rs7650509 chr3:134170971 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.38 11.38 0.41 1.98e-27 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs36051895 0.659 rs62541539 chr9:5038180 C/T cg02405213 chr9:5042618 JAK2 -0.47 -8.62 -0.32 5.24e-17 Pediatric autoimmune diseases; BRCA cis rs597539 0.652 rs602364 chr11:68662167 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.76 18.46 0.59 2.66e-61 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA trans rs2736337 0.530 rs2003422 chr8:11303137 G/C cg15556689 chr8:8085844 FLJ10661 0.33 8.18 0.31 1.56e-15 Rheumatoid arthritis; BRCA cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg06494592 chr3:125709126 NA -0.54 -8.67 -0.32 3.54e-17 Blood pressure (smoking interaction); BRCA trans rs7615952 0.576 rs1127717 chr3:125826059 T/C cg07211511 chr3:129823064 LOC729375 -0.62 -11.45 -0.41 9.31e-28 Blood pressure (smoking interaction); BRCA cis rs2806561 0.754 rs10917344 chr1:23342193 C/G cg19743168 chr1:23544995 NA -0.42 -9.89 -0.36 1.53e-21 Height; BRCA cis rs9986765 0.609 rs73452600 chr7:142828104 C/A cg22531018 chr7:142981779 TMEM139 0.65 10.25 0.38 6.42e-23 Cancer;Dermatomyositis; BRCA cis rs7572733 0.515 rs12619300 chr2:198786490 A/C cg00792783 chr2:198669748 PLCL1 -0.46 -9.98 -0.37 7.05e-22 Dermatomyositis; BRCA cis rs10992471 0.603 rs10992349 chr9:95233887 T/C cg14631576 chr9:95140430 CENPP -0.38 -9.27 -0.34 2.93e-19 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs8028182 0.636 rs11636031 chr15:75815758 T/C cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 17.12 0.56 2.22e-54 Age-related macular degeneration (geographic atrophy); BRCA cis rs7586879 1.000 rs7608185 chr2:25115432 G/C cg01884057 chr2:25150051 NA 0.33 8.35 0.31 4.28e-16 Body mass index; BRCA cis rs2839186 0.771 rs2839155 chr21:47639992 A/G cg05896524 chr21:47604654 C21orf56 0.5 9.67 0.36 9.66e-21 Testicular germ cell tumor; BRCA cis rs6088590 1.000 rs6087632 chr20:33407704 A/C cg08999081 chr20:33150536 PIGU 0.36 9.27 0.34 2.78e-19 Coronary artery disease; BRCA cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg08859206 chr1:53392774 SCP2 0.54 11.88 0.43 1.47e-29 Monocyte count; BRCA cis rs11123170 0.542 rs11123169 chr2:113967075 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.42 -7.87 -0.3 1.5e-14 Renal function-related traits (BUN); BRCA cis rs427394 0.664 rs274722 chr5:6718668 C/T cg10857441 chr5:6722123 POLS -0.32 -10.95 -0.4 1.08e-25 Menopause (age at onset); BRCA cis rs13191362 1.000 rs36007635 chr6:163009335 G/A cg21926612 chr6:163149169 PACRG;PARK2 0.87 14.13 0.49 1.18e-39 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs938554 0.578 rs7663032 chr4:9993838 C/T cg00071950 chr4:10020882 SLC2A9 0.42 9.02 0.34 2.21e-18 Blood metabolite levels; BRCA cis rs3760982 0.585 rs67648499 chr19:44294055 G/A cg12072164 chr19:44306565 LYPD5 0.37 8.71 0.33 2.63e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs6782228 0.585 rs9841161 chr3:128331870 A/G cg16766828 chr3:128327626 NA -0.42 -9.23 -0.34 3.82e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7618501 0.602 rs2245365 chr3:50097319 C/A cg05623727 chr3:50126028 RBM5 -0.41 -9.9 -0.36 1.3e-21 Intelligence (multi-trait analysis); BRCA cis rs873946 0.564 rs12772704 chr10:134557318 G/A cg06453172 chr10:134556979 INPP5A -0.6 -11.77 -0.42 4.54e-29 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs1476670 0.710 rs2485993 chr1:44503040 C/T cg09470012 chr1:44509516 NA -0.44 -9.54 -0.35 2.86e-20 Eotaxin levels; BRCA cis rs9811920 0.598 rs793470 chr3:99548274 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 12.76 0.45 2.31e-33 Axial length; BRCA cis rs7092929 0.689 rs964162 chr10:3535233 C/T cg14308648 chr10:3568949 NA 0.4 8.77 0.33 1.56e-17 Coronary artery calcification; BRCA cis rs2204008 0.749 rs10880692 chr12:38592918 C/G cg13010199 chr12:38710504 ALG10B -0.52 -10.49 -0.38 7.48e-24 Bladder cancer; BRCA cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.8 -0.51 7.97e-43 Total cholesterol levels; BRCA cis rs4363385 0.747 rs4845332 chr1:152982632 C/T cg24667326 chr1:152973720 SPRR3 -0.35 -9.87 -0.36 1.81e-21 Inflammatory skin disease; BRCA cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg21770322 chr7:97807741 LMTK2 0.4 10.38 0.38 1.96e-23 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg18876405 chr7:65276391 NA -0.48 -10.46 -0.38 9.72e-24 Aortic root size; BRCA trans rs11098499 0.866 rs6857892 chr4:120282696 G/T cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs35110281 0.501 rs162381 chr21:44920915 A/G cg04455712 chr21:45112962 RRP1B -0.36 -8.79 -0.33 1.35e-17 Mean corpuscular volume; BRCA cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.63 -8.93 -0.33 4.55e-18 Schizophrenia; BRCA cis rs9287719 0.967 rs7582775 chr2:10738449 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs6952808 1.000 rs10233560 chr7:1885415 T/C cg02951883 chr7:2050386 MAD1L1 -0.39 -8.7 -0.33 2.9e-17 Bipolar disorder and schizophrenia; BRCA cis rs72615157 0.634 rs2272343 chr7:99778285 A/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.56 8.77 0.33 1.6e-17 Lung function (FEV1/FVC); BRCA trans rs1493916 0.967 rs9953765 chr18:31399464 A/G cg27147174 chr7:100797783 AP1S1 -0.54 -10.84 -0.39 2.87e-25 Life satisfaction; BRCA cis rs1030877 0.960 rs3792050 chr2:105902255 T/C cg02079111 chr2:105885981 TGFBRAP1 -0.67 -15.99 -0.53 1.15e-48 Obesity-related traits; BRCA cis rs1707322 1.000 rs7547189 chr1:46319514 C/A cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.65e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg18765753 chr7:1198926 ZFAND2A -0.46 -10.27 -0.38 5.17e-23 Longevity;Endometriosis; BRCA cis rs7613875 0.663 rs6762477 chr3:50093209 G/A cg24110177 chr3:50126178 RBM5 0.5 14.23 0.49 4.17e-40 Body mass index; BRCA cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg21475434 chr5:93447410 FAM172A 0.65 8.65 0.32 4e-17 Diabetic retinopathy; BRCA cis rs3768617 0.811 rs61808068 chr1:182979377 T/A ch.1.3577855R chr1:183094577 LAMC1 0.45 9.88 0.36 1.55e-21 Fuchs's corneal dystrophy; BRCA cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg06115741 chr20:33292138 TP53INP2 -0.5 -11.27 -0.41 5.51e-27 Coronary artery disease; BRCA cis rs739401 0.572 rs410820 chr11:3080102 G/A cg05729581 chr11:3078854 CARS -0.34 -8.31 -0.31 5.79e-16 Longevity; BRCA cis rs11583043 0.918 rs6693456 chr1:101424561 A/G cg00063077 chr1:101360652 SLC30A7;EXTL2 0.46 9.28 0.34 2.56e-19 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs2070488 0.775 rs11926767 chr3:38527913 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.56 -14.29 -0.49 2.19e-40 Electrocardiographic conduction measures; BRCA cis rs798502 0.522 rs7790322 chr7:2830498 C/T cg18446336 chr7:2847575 GNA12 -0.41 -9.3 -0.35 2.17e-19 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg11057378 chr10:81107060 PPIF 0.39 8.87 0.33 7.03e-18 Height; BRCA cis rs17270561 0.609 rs6924794 chr6:25735874 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs796364 1.000 rs281788 chr2:200783705 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.69 0.42 9.87e-29 Schizophrenia; BRCA cis rs2880765 0.545 rs17553734 chr15:86013059 C/G cg19183879 chr15:85880815 NA 0.32 7.87 0.3 1.48e-14 Coronary artery disease; BRCA cis rs72781680 0.898 rs113027486 chr2:24098371 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.02 0.34 2.15e-18 Lymphocyte counts; BRCA cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg08213375 chr14:104286397 PPP1R13B -0.64 -17.83 -0.58 5.23e-58 Schizophrenia; BRCA cis rs7523050 0.643 rs7522324 chr1:109399644 T/C cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs6701037 0.566 rs1883102 chr1:175136793 T/A cg14847009 chr1:175162515 KIAA0040 0.25 9.63 0.36 1.38e-20 Alcohol dependence; BRCA cis rs3858526 1.000 rs11039787 chr11:5965611 C/T cg02574844 chr11:5959923 NA -0.42 -8.17 -0.31 1.61e-15 DNA methylation (variation); BRCA cis rs10504229 0.679 rs11783444 chr8:58131267 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs2806561 1.000 rs681753 chr1:23515216 T/C cg19743168 chr1:23544995 NA 0.43 10.59 0.39 2.92e-24 Height; BRCA cis rs2739330 0.828 rs4820572 chr22:24250355 T/C cg23131131 chr22:24373011 LOC391322 -0.46 -10.71 -0.39 1e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1403694 0.695 rs3821815 chr3:186434262 A/G cg12454167 chr3:186435060 KNG1 0.3 8.16 0.31 1.74e-15 Blood protein levels; BRCA cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs9788721 0.806 rs4887056 chr15:78734585 A/G cg18825076 chr15:78729989 IREB2 -0.4 -8.28 -0.31 7.31e-16 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs7953249 0.564 rs11065385 chr12:121423386 A/G cg02403541 chr12:121454288 C12orf43 -0.51 -9.68 -0.36 9.26e-21 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA trans rs9329221 0.710 rs11785061 chr8:10259528 G/C cg06636001 chr8:8085503 FLJ10661 0.47 9.01 0.34 2.38e-18 Neuroticism; BRCA cis rs11608355 0.545 rs918107 chr12:109904198 C/T cg05360138 chr12:110035743 NA -0.71 -13.07 -0.46 9.4e-35 Neuroticism; BRCA cis rs1862618 0.853 rs860580 chr5:56149429 G/T cg20203395 chr5:56204925 C5orf35 0.5 10.31 0.38 3.66e-23 Initial pursuit acceleration; BRCA cis rs8032158 1.000 rs8026172 chr15:56125182 T/A cg02198044 chr15:56286336 NEDD4 -0.38 -9.04 -0.34 1.8e-18 Keloid; BRCA cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.42e-39 Lymphocyte counts; BRCA cis rs1552244 1.000 rs17032299 chr3:10087638 C/T cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.53e-38 Alzheimer's disease; BRCA cis rs4862307 0.836 rs4862304 chr4:184996607 C/T cg06737308 chr4:185021514 ENPP6 0.41 9.27 0.34 2.82e-19 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs2304069 0.954 rs9324640 chr5:149413186 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.77 -15.92 -0.53 2.71e-48 HIV-1 control; BRCA cis rs1511802 0.501 rs7683132 chr4:187116039 A/G cg24794857 chr4:187113578 CYP4V2 0.36 7.91 0.3 1.12e-14 Blood protein levels; BRCA cis rs9811920 0.638 rs704581 chr3:99556160 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.69 -15.62 -0.53 7.93e-47 Axial length; BRCA cis rs61990749 0.544 rs2544566 chr14:78181738 C/G cg02301378 chr14:78227641 SNW1;C14orf178 0.64 10.06 0.37 3.36e-22 Fibroblast growth factor basic levels; BRCA cis rs1801251 1.000 rs4973053 chr2:233670099 G/A cg25237894 chr2:233734115 C2orf82 -0.4 -11.55 -0.42 3.53e-28 Coronary artery disease; BRCA cis rs10927875 0.864 rs12135073 chr1:16167799 C/T cg21385522 chr1:16154831 NA 0.88 16.45 0.55 5.94e-51 Dilated cardiomyopathy; BRCA cis rs1865760 0.566 rs1971509 chr6:26085777 T/C cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA cis rs9818758 0.607 rs67060340 chr3:48915321 C/T cg00383909 chr3:49044727 WDR6 0.93 15.37 0.52 1.34e-45 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs2011503 1.000 rs80200208 chr19:19554725 C/T cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg13732083 chr21:47605072 C21orf56 0.37 7.95 0.3 8.68e-15 Testicular germ cell tumor; BRCA cis rs13118159 0.771 rs13117476 chr4:1334721 A/G cg05025164 chr4:1340916 KIAA1530 0.43 9.62 0.36 1.53e-20 Longevity; BRCA cis rs3096299 0.606 rs8052103 chr16:89541243 A/T cg16743903 chr16:89593216 SPG7 0.4 9.7 0.36 7.37e-21 Multiple myeloma (IgH translocation); BRCA cis rs7666738 0.962 rs17027204 chr4:98997049 G/A cg03676636 chr4:99064102 C4orf37 0.23 8.26 0.31 8.59e-16 Colonoscopy-negative controls vs population controls; BRCA trans rs3780486 0.846 rs3780490 chr9:33129839 A/G cg04842962 chr6:43655489 MRPS18A 1.11 38.51 0.84 1.1e-168 IgG glycosylation; BRCA cis rs13064411 0.866 rs35278902 chr3:113239021 A/G cg18753928 chr3:113234510 CCDC52 -0.59 -9.62 -0.36 1.55e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs4363385 0.818 rs2070964 chr1:153004213 C/T cg25856811 chr1:152973957 SPRR3 -0.31 -8.12 -0.31 2.32e-15 Inflammatory skin disease; BRCA trans rs1459104 1.000 rs35317943 chr11:55274857 C/T cg15704280 chr7:45808275 SEPT13 0.65 8.14 0.31 2.12e-15 Body mass index; BRCA cis rs7178424 0.764 rs11634163 chr15:62330633 C/T cg00456672 chr15:62358751 C2CD4A -0.41 -9.02 -0.34 2.14e-18 Height; BRCA cis rs3916 0.955 rs2066938 chr12:121160615 A/G cg21892295 chr12:121157589 UNC119B -0.36 -9.72 -0.36 6.33e-21 Urinary metabolites (H-NMR features); BRCA cis rs11098499 0.954 rs71629403 chr4:120372567 C/T cg09307838 chr4:120376055 NA 0.72 15.37 0.52 1.39e-45 Corneal astigmatism; BRCA cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg25767906 chr1:53392781 SCP2 0.52 10.98 0.4 8.37e-26 Monocyte count; BRCA cis rs7615952 0.599 rs6438955 chr3:125730333 C/A cg15145296 chr3:125709740 NA -0.5 -8.57 -0.32 7.55e-17 Blood pressure (smoking interaction); BRCA cis rs4588572 0.643 rs6453396 chr5:77785387 T/C cg11547950 chr5:77652471 NA -0.48 -8.44 -0.32 2.05e-16 Triglycerides; BRCA cis rs425277 0.606 rs2257182 chr1:2082566 C/T cg19257562 chr1:2043853 PRKCZ 0.31 8.48 0.32 1.59e-16 Height; BRCA cis rs700651 0.789 rs1978889 chr2:198889366 G/A cg00792783 chr2:198669748 PLCL1 0.38 8.74 0.33 2.06e-17 Intracranial aneurysm; BRCA cis rs597539 0.652 rs557625 chr11:68634722 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.72 16.6 0.55 9.86e-52 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs992157 0.775 rs1877714 chr2:219134928 A/G cg20019365 chr2:219134978 PNKD;AAMP -0.5 -10.94 -0.4 1.14e-25 Colorectal cancer; BRCA cis rs7666738 0.830 rs7661264 chr4:98961574 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg11663144 chr21:46675770 NA -0.62 -14.29 -0.49 2.23e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs61931739 0.534 rs4931775 chr12:34050729 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.37 0.49 9.31e-41 Morning vs. evening chronotype; BRCA cis rs36051895 0.626 rs10283564 chr9:5075628 C/G cg02405213 chr9:5042618 JAK2 -0.55 -9.73 -0.36 5.89e-21 Pediatric autoimmune diseases; BRCA cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg17971929 chr21:40555470 PSMG1 -0.48 -10.56 -0.39 3.96e-24 Menarche (age at onset); BRCA cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.5 0.32 1.33e-16 Aortic root size; BRCA cis rs3857067 0.806 rs6532471 chr4:95108584 T/C cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.34 -0.35 1.56e-19 QT interval; BRCA cis rs910316 1.000 rs175426 chr14:75624134 C/T cg11812906 chr14:75593930 NEK9 -0.62 -14.2 -0.49 5.56e-40 Height; BRCA cis rs7493 0.950 rs12704794 chr7:95036133 A/T cg19678392 chr7:94953810 PON1 -0.42 -9.11 -0.34 1.03e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs12579753 0.917 rs11115029 chr12:82202219 C/G cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.96 15.16 0.51 1.39e-44 Platelet count; BRCA cis rs701145 0.585 rs1727946 chr3:153826470 C/T cg17054900 chr3:154042577 DHX36 0.53 9.04 0.34 1.88e-18 Coronary artery disease; BRCA cis rs28374715 0.532 rs7164211 chr15:41705041 A/T cg18705301 chr15:41695430 NDUFAF1 -1.06 -28.2 -0.74 2.79e-114 Ulcerative colitis; BRCA cis rs2835872 0.758 rs1709817 chr21:39036349 T/A cg06728970 chr21:39037746 KCNJ6 0.45 12.85 0.45 9.07e-34 Electroencephalographic traits in alcoholism; BRCA cis rs6598955 0.543 rs4585968 chr1:26535146 G/A cg04990556 chr1:26633338 UBXN11 0.7 11.69 0.42 9.64e-29 Obesity-related traits; BRCA cis rs6952808 0.689 rs11771625 chr7:2050401 C/T cg05863683 chr7:1912471 MAD1L1 0.38 8.42 0.32 2.55e-16 Bipolar disorder and schizophrenia; BRCA cis rs11711311 1.000 rs12695295 chr3:113474866 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.47 -10.58 -0.39 3.19e-24 IgG glycosylation; BRCA cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg13628971 chr7:2884303 GNA12 0.38 8.52 0.32 1.17e-16 Height; BRCA cis rs6066825 0.644 rs6125442 chr20:47331210 C/G cg18078177 chr20:47281410 PREX1 0.39 9.52 0.35 3.58e-20 Colorectal cancer; BRCA cis rs10504229 1.000 rs73607863 chr8:58170178 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.61 -0.32 5.7e-17 Developmental language disorder (linguistic errors); BRCA trans rs1459104 1.000 rs1974931 chr11:55198460 A/G cg15704280 chr7:45808275 SEPT13 0.65 8.16 0.31 1.76e-15 Body mass index; BRCA cis rs2153535 0.580 rs1335633 chr6:8448800 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs798554 0.679 rs1636254 chr7:2885724 T/C cg12444411 chr7:2802554 GNA12 -0.31 -7.91 -0.3 1.14e-14 Height; BRCA cis rs36051895 0.589 rs7038763 chr9:5076399 T/C cg02405213 chr9:5042618 JAK2 -0.52 -10.09 -0.37 2.59e-22 Pediatric autoimmune diseases; BRCA cis rs780096 0.506 rs72819512 chr2:27614449 G/A cg02592271 chr2:27665507 KRTCAP3 -0.32 -7.81 -0.3 2.33e-14 Total body bone mineral density; BRCA trans rs7824557 0.707 rs3808518 chr8:11143272 A/C cg06636001 chr8:8085503 FLJ10661 -0.52 -10.47 -0.38 9.18e-24 Retinal vascular caliber; BRCA cis rs4845875 0.626 rs6540999 chr1:11833366 A/G cg24844545 chr1:11908347 NPPA 0.31 7.85 0.3 1.8e-14 Midregional pro atrial natriuretic peptide levels; BRCA cis rs7829975 0.714 rs4841042 chr8:8664622 A/G cg08975724 chr8:8085496 FLJ10661 -0.43 -9.6 -0.36 1.78e-20 Mood instability; BRCA cis rs2153535 0.580 rs6900007 chr6:8474035 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.23e-23 Motion sickness; BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg15112475 chr7:1198522 ZFAND2A -0.59 -13.46 -0.47 1.49e-36 Longevity;Endometriosis; BRCA cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg01475377 chr6:109611718 NA -0.52 -12.99 -0.46 2.19e-34 Reticulocyte fraction of red cells; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg09256448 chr16:638327 NA 0.3 7.88 0.3 1.37e-14 Height; BRCA cis rs9818758 0.607 rs9862483 chr3:49195441 G/A cg00383909 chr3:49044727 WDR6 0.78 13.01 0.46 1.69e-34 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7766436 0.885 rs12111199 chr6:22578106 C/T cg13666174 chr6:22585274 NA -0.49 -11.29 -0.41 4.4e-27 Coronary artery disease; BRCA cis rs897080 0.515 rs2616449 chr2:44597262 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.57 9.64 0.36 1.28e-20 Height; BRCA cis rs881375 1.000 rs10760121 chr9:123647915 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.69 0.32 3.15e-17 Rheumatoid arthritis; BRCA cis rs7246657 0.722 rs1975937 chr19:38091932 A/T cg14683738 chr19:37701593 ZNF585B 0.46 7.89 0.3 1.33e-14 Coronary artery calcification; BRCA cis rs10504229 0.953 rs115634610 chr8:58190533 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.51 -0.47 9.38e-37 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs13101352 chr4:98957544 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.64 0.39 1.93e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2032447 0.772 rs199754 chr6:25992309 A/G cg03517284 chr6:25882590 NA -0.5 -10.12 -0.37 1.91e-22 Intelligence (multi-trait analysis); BRCA cis rs17601876 0.778 rs11632926 chr15:51564226 G/A cg19946085 chr15:51559439 CYP19A1 -0.38 -11.12 -0.4 2.3e-26 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs701145 0.585 rs1713839 chr3:153829105 A/G cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.2e-14 Coronary artery disease; BRCA cis rs1580019 0.523 rs9791770 chr7:32582252 C/A cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.38 0.38 2.01e-23 Cognitive ability; BRCA cis rs965469 0.779 rs57373308 chr20:3314715 G/C cg25506879 chr20:3388711 C20orf194 -0.43 -8.55 -0.32 9.25e-17 IFN-related cytopenia; BRCA trans rs3857536 0.776 rs6941904 chr6:66931042 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.08 -0.3 3.22e-15 Blood trace element (Cu levels); BRCA cis rs16958440 0.867 rs77615793 chr18:44684464 C/G cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA trans rs7647973 0.710 rs6446284 chr3:49616997 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -7.86 -0.3 1.65e-14 Menarche (age at onset); BRCA cis rs1043763 0.826 rs4075625 chr12:122610593 A/T cg14400030 chr12:122498111 BCL7A -0.62 -13.86 -0.48 2.27e-38 Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs); BRCA cis rs3857067 0.740 rs6532470 chr4:95108211 C/G cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.34 -0.35 1.56e-19 QT interval; BRCA cis rs1994135 0.647 rs67243558 chr12:33695383 T/C cg06521331 chr12:34319734 NA -0.44 -8.06 -0.3 3.7e-15 Resting heart rate; BRCA cis rs2075371 0.611 rs12531769 chr7:134016899 C/G cg11752832 chr7:134001865 SLC35B4 0.43 9.75 0.36 5.02e-21 Mean platelet volume; BRCA cis rs1008375 1.000 rs12507142 chr4:17656103 A/G cg02297831 chr4:17616191 MED28 0.38 8.81 0.33 1.15e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs9467711 0.659 rs66941101 chr6:26530376 C/T cg01620082 chr3:125678407 NA -0.7 -8.74 -0.33 2e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs4665809 1.000 rs2289022 chr2:26350136 G/T cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs6546768 chr2:26328800 A/G cg26314531 chr2:26401878 FAM59B -0.63 -10.83 -0.39 3.28e-25 Gut microbiome composition (summer); BRCA trans rs9409565 0.826 rs2769813 chr9:97151194 C/T cg05679027 chr9:99775184 HIATL2 0.42 9.23 0.34 3.86e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs6582630 0.502 rs4559747 chr12:38436235 G/A cg26384229 chr12:38710491 ALG10B 0.67 15.92 0.53 2.53e-48 Drug-induced liver injury (flucloxacillin); BRCA cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg26769984 chr7:1090371 C7orf50 0.64 11.34 0.41 2.67e-27 Bronchopulmonary dysplasia; BRCA cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg03351412 chr1:154909251 PMVK 0.61 14.21 0.49 5.26e-40 Prostate cancer; BRCA cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg10802521 chr3:52805072 NEK4 0.34 9.42 0.35 8.39e-20 Bipolar disorder; BRCA trans rs1997103 0.705 rs56301138 chr7:55396555 G/T cg20935933 chr6:143382018 AIG1 0.6 11.52 0.41 4.77e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1552244 0.882 rs55962400 chr3:10044457 C/T cg16606324 chr3:10149918 C3orf24 0.46 7.96 0.3 7.96e-15 Alzheimer's disease; BRCA trans rs3780486 0.846 rs3780487 chr9:33139237 T/C cg20290983 chr6:43655470 MRPS18A 1.11 41.43 0.85 3.52e-183 IgG glycosylation; BRCA cis rs911555 0.655 rs10141157 chr14:104018105 T/C cg12935359 chr14:103987150 CKB -0.52 -12.39 -0.44 9.56e-32 Intelligence (multi-trait analysis); BRCA trans rs3857536 0.706 rs7749120 chr6:66889832 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.48 -9.67 -0.36 1.01e-20 Blood trace element (Cu levels); BRCA cis rs875971 0.862 rs4236208 chr7:65749078 C/T cg11764359 chr7:65958608 NA -0.78 -17.68 -0.57 3.13e-57 Aortic root size; BRCA cis rs6831352 0.589 rs1133483 chr4:100023923 G/C cg13256891 chr4:100009986 ADH5 0.53 12.29 0.44 2.71e-31 Alcohol dependence; BRCA cis rs7254827 1.000 rs4808567 chr19:17215381 C/T cg19418318 chr19:17219073 MYO9B -0.49 -10.21 -0.37 8.7e-23 Mean platelet volume; BRCA cis rs7666738 0.830 rs13147768 chr4:98833675 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.23 0.38 7.64e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs524281 0.861 rs10750780 chr11:65974592 G/A cg16950941 chr11:66035639 RAB1B -0.38 -8.05 -0.3 3.97e-15 Electroencephalogram traits; BRCA cis rs12477438 0.798 rs4850894 chr2:99629396 A/T cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs332507 0.830 rs1846892 chr3:124399293 A/G cg05980111 chr3:124395277 KALRN 0.36 8.39 0.32 3.03e-16 Plateletcrit; BRCA cis rs2836974 0.831 rs11911149 chr21:40528375 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.87 0.6 1.9e-63 Cognitive function; BRCA cis rs12477438 1.000 rs17760953 chr2:99859863 G/A cg08885076 chr2:99613938 TSGA10 -0.49 -9.69 -0.36 8.33e-21 Chronic sinus infection; BRCA cis rs1348850 0.526 rs7588049 chr2:178390778 C/T cg27490568 chr2:178487706 NA -0.54 -8.58 -0.32 7.16e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7539409 0.651 rs969724 chr1:84300712 T/G cg10977910 chr1:84465055 TTLL7 0.7 10.59 0.39 2.94e-24 Alzheimer's disease; BRCA cis rs597539 0.652 rs668576 chr11:68668208 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 18.8 0.6 4.08e-63 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1401999 0.546 rs4148593 chr3:183649870 A/G cg01324343 chr3:183735012 ABCC5 0.49 11.21 0.41 9.36e-27 Anterior chamber depth; BRCA cis rs66887589 0.807 rs9799664 chr4:120326678 C/T cg09307838 chr4:120376055 NA 0.46 9.63 0.36 1.42e-20 Diastolic blood pressure; BRCA cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg18132916 chr6:79620363 NA 0.47 10.44 0.38 1.15e-23 Intelligence (multi-trait analysis); BRCA cis rs9309711 0.736 rs13409102 chr2:3496321 G/A cg10845886 chr2:3471009 TTC15 -0.67 -13.12 -0.46 5.44e-35 Neurofibrillary tangles; BRCA cis rs6867032 1.000 rs2129472 chr5:2016247 G/A cg26168224 chr5:2018326 NA 0.64 17.74 0.57 1.49e-57 Gut microbiome composition (winter); BRCA cis rs9427116 0.502 rs9427104 chr1:154589232 C/T cg17218026 chr1:154582156 ADAR 0.28 8.47 0.32 1.74e-16 Blood protein levels; BRCA cis rs3008870 0.959 rs1886686 chr1:67390468 C/G cg08660285 chr1:67390436 MIER1;WDR78 0.98 21.58 0.65 5.31e-78 Lymphocyte percentage of white cells; BRCA cis rs3768617 0.903 rs10911251 chr1:183081194 A/C ch.1.3577855R chr1:183094577 LAMC1 0.49 11.29 0.41 4.51e-27 Fuchs's corneal dystrophy; BRCA cis rs8031584 0.697 rs8036176 chr15:31175269 A/G cg08704250 chr15:31115839 NA -0.42 -11.03 -0.4 5.21e-26 Huntington's disease progression; BRCA cis rs11583043 0.918 rs6675403 chr1:101418569 T/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.43 9.48 0.35 5.05e-20 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.43 -0.32 2.31e-16 Total body bone mineral density; BRCA cis rs1801251 1.000 rs4517962 chr2:233578337 T/C cg25237894 chr2:233734115 C2orf82 0.39 11.16 0.4 1.59e-26 Coronary artery disease; BRCA cis rs12477438 0.501 rs2632284 chr2:99775865 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.77 0.67 1.63e-84 Chronic sinus infection; BRCA cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg07606381 chr6:8435919 SLC35B3 0.64 14.17 0.49 7.85e-40 Motion sickness; BRCA cis rs2645694 0.626 rs2645704 chr4:77830805 T/C cg18351406 chr4:77819688 ANKRD56 0.58 12.68 0.45 5.06e-33 Emphysema distribution in smoking; BRCA cis rs2075371 0.897 rs1643102 chr7:133999983 T/A cg11752832 chr7:134001865 SLC35B4 0.52 13.55 0.47 6.19e-37 Mean platelet volume; BRCA cis rs3806843 0.900 rs2261651 chr5:140136804 A/C cg16179182 chr5:140090404 VTRNA1-1 0.43 10.14 0.37 1.68e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs6089584 0.853 rs1746280 chr20:60577821 C/G cg23262073 chr20:60523788 NA -0.4 -8.89 -0.33 6.37e-18 Body mass index; BRCA trans rs7618501 1.000 rs3811696 chr3:49761605 C/T cg21659725 chr3:3221576 CRBN -0.71 -21.91 -0.65 8.31e-80 Intelligence (multi-trait analysis); BRCA cis rs9788682 0.747 rs8042059 chr15:78907859 A/C cg24631222 chr15:78858424 CHRNA5 0.46 9.68 0.36 8.67e-21 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs72781680 1.000 rs61739076 chr2:24149439 G/A cg08917208 chr2:24149416 ATAD2B 1.12 15.97 0.53 1.45e-48 Lymphocyte counts; BRCA cis rs921968 0.612 rs2384950 chr2:219499719 T/C cg02176678 chr2:219576539 TTLL4 0.44 11.53 0.42 4.3e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs1400816 0.850 rs6433313 chr2:172657696 A/C cg13550731 chr2:172543902 DYNC1I2 -0.5 -7.94 -0.3 9.31e-15 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs4880487 0.888 rs67456501 chr10:1252400 G/A cg03183215 chr10:1252341 ADARB2 -0.39 -8.8 -0.33 1.32e-17 Migraine; BRCA cis rs61931739 0.500 rs11836207 chr12:34315177 G/A cg06521331 chr12:34319734 NA -0.67 -13.9 -0.48 1.42e-38 Morning vs. evening chronotype; BRCA cis rs2688608 0.592 rs12253429 chr10:75496161 C/G cg23231163 chr10:75533350 FUT11 -0.33 -8.65 -0.32 4.07e-17 Inflammatory bowel disease; BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -12.58 -0.45 1.38e-32 Alzheimer's disease; BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg14863265 chr7:2801509 GNA12 -0.45 -9.76 -0.36 4.72e-21 Height; BRCA cis rs11858210 1 rs11858210 chr15:79078358 G/A cg04896959 chr15:78267971 NA 0.37 8.55 0.32 9.24e-17 Post bronchodilator FEV1/FVC ratio; BRCA cis rs6545883 0.894 rs2694643 chr2:61604383 A/G cg15711740 chr2:61764176 XPO1 -0.5 -12.2 -0.43 6.39e-31 Tuberculosis; BRCA cis rs588177 0.613 rs3782101 chr11:64131280 A/G cg24431193 chr11:63883947 FLRT1;MACROD1 0.33 8.21 0.31 1.18e-15 High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA trans rs2204008 0.728 rs11495375 chr12:38282631 G/A cg06521331 chr12:34319734 NA -0.52 -9.54 -0.35 3.06e-20 Bladder cancer; BRCA cis rs1476670 0.690 rs6677372 chr1:44505789 G/A cg09470012 chr1:44509516 NA 0.37 8.31 0.31 5.67e-16 Eotaxin levels; BRCA cis rs4665809 0.590 rs3806514 chr2:26466772 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.57 10.18 0.37 1.13e-22 Gut microbiome composition (summer); BRCA cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg04414720 chr1:150670196 GOLPH3L 0.36 8.12 0.31 2.4e-15 Tonsillectomy; BRCA cis rs7552167 0.925 rs3932666 chr1:24511566 G/A cg01960748 chr1:24522592 NA -0.62 -10.17 -0.37 1.23e-22 Psoriasis vulgaris; BRCA cis rs6724607 1.000 rs7598979 chr2:191453375 A/G cg21644426 chr2:191273491 MFSD6 0.44 11.39 0.41 1.7e-27 Pulse pressure; BRCA cis rs77956314 0.515 rs9804817 chr12:117440220 G/A cg06698575 chr12:117470875 NA -0.46 -8.29 -0.31 6.64e-16 Subcortical brain region volumes;Hippocampal volume; BRCA cis rs7829975 0.688 rs7827182 chr8:8380471 C/G cg15556689 chr8:8085844 FLJ10661 0.48 13.53 0.47 7.65e-37 Mood instability; BRCA cis rs9807989 0.507 rs1592459 chr2:103031569 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma; BRCA cis rs7726839 0.555 rs4541696 chr5:581053 A/G cg09021430 chr5:549028 NA -0.65 -23.19 -0.68 9.09e-87 Obesity-related traits; BRCA cis rs4665809 0.590 rs2891496 chr2:26452605 G/A cg27170947 chr2:26402098 FAM59B 0.98 17.2 0.56 9.41e-55 Gut microbiome composition (summer); BRCA cis rs977987 0.806 rs8050769 chr16:75388434 C/T cg03315344 chr16:75512273 CHST6 0.51 11.91 0.43 1.16e-29 Dupuytren's disease; BRCA cis rs7826238 0.623 rs2976893 chr8:8338219 G/T cg06636001 chr8:8085503 FLJ10661 -0.6 -12.8 -0.45 1.48e-33 Systolic blood pressure; BRCA cis rs2832191 0.716 rs2249028 chr21:30365322 G/A cg24692254 chr21:30365293 RNF160 0.79 22.11 0.66 6.61e-81 Dental caries; BRCA cis rs13108904 0.870 rs1564508 chr4:1244879 A/G cg05665937 chr4:1216051 CTBP1 0.37 7.82 0.3 2.25e-14 Obesity-related traits; BRCA cis rs17401966 0.838 rs12120191 chr1:10345772 A/G cg03954927 chr1:10346856 KIF1B 0.44 13.99 0.48 5.28e-39 Hepatocellular carcinoma; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg03188948 chr7:1209495 NA 0.59 11.15 0.4 1.65e-26 Longevity;Endometriosis; BRCA cis rs6542838 0.553 rs6739503 chr2:99537295 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.13 -0.34 8.73e-19 Fear of minor pain; BRCA cis rs881375 0.678 rs10739581 chr9:123696871 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.6 0.32 6.13e-17 Rheumatoid arthritis; BRCA trans rs61931739 0.500 rs7303318 chr12:34467789 T/C cg26384229 chr12:38710491 ALG10B 0.58 13.11 0.46 5.78e-35 Morning vs. evening chronotype; BRCA cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg06238570 chr21:40685208 BRWD1 -0.39 -8.03 -0.3 4.59e-15 Menarche (age at onset); BRCA cis rs6089829 0.962 rs4809456 chr20:61660849 C/A cg08564027 chr20:61660810 NA 0.85 22.6 0.67 1.54e-83 Prostate cancer (SNP x SNP interaction); BRCA trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg13010199 chr12:38710504 ALG10B 0.43 9.08 0.34 1.35e-18 Morning vs. evening chronotype; BRCA cis rs2439831 0.850 rs28595038 chr15:44044859 A/C cg27015174 chr15:43622946 ADAL;LCMT2 0.53 10.17 0.37 1.24e-22 Lung cancer in ever smokers; BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg27170947 chr2:26402098 FAM59B -0.66 -11.24 -0.41 7.23e-27 Gut microbiome composition (summer); BRCA cis rs875971 0.619 rs10278371 chr7:66051540 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.28 -0.31 7.06e-16 Aortic root size; BRCA cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg06453172 chr10:134556979 INPP5A -0.53 -11.27 -0.41 5.55e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs3733585 0.673 rs10000983 chr4:9951606 T/C cg00071950 chr4:10020882 SLC2A9 -0.47 -11.01 -0.4 6.16e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2404602 0.647 rs11631394 chr15:76973209 G/T cg23625390 chr15:77176239 SCAPER -0.57 -14.85 -0.51 4.61e-43 Blood metabolite levels; BRCA cis rs4595586 0.545 rs12823721 chr12:39386461 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs10461617 0.592 rs6450403 chr5:56062737 A/C cg24531977 chr5:56204891 C5orf35 -0.63 -12.58 -0.45 1.39e-32 Type 2 diabetes; BRCA cis rs919433 0.648 rs3097384 chr2:198278834 T/A cg00792783 chr2:198669748 PLCL1 0.38 8.56 0.32 8.15e-17 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1443512 0.812 rs2044210 chr12:54335533 C/G cg17410650 chr12:54324560 NA -0.42 -10.33 -0.38 3.08e-23 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs7618915 0.524 rs12488461 chr3:52698417 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.45 9.62 0.36 1.52e-20 Bipolar disorder; BRCA cis rs6121246 0.559 rs6060919 chr20:30331922 A/T cg13852791 chr20:30311386 BCL2L1 0.96 23.39 0.68 6.61e-88 Mean corpuscular hemoglobin; BRCA cis rs2645694 0.626 rs2703120 chr4:77822470 G/A cg06046430 chr4:77819534 ANKRD56 0.58 12.94 0.46 3.41e-34 Emphysema distribution in smoking; BRCA cis rs1863824 0.625 rs12354988 chr10:88155204 G/A cg07322936 chr10:88137208 NA -0.44 -8.74 -0.33 2.07e-17 Schizophrenia; BRCA cis rs36051895 0.589 rs17492549 chr9:5202830 A/C cg02405213 chr9:5042618 JAK2 -0.43 -8.02 -0.3 5.09e-15 Pediatric autoimmune diseases; BRCA cis rs7772486 0.686 rs9497380 chr6:145955305 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.51 0.57 2.19e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs250677 0.522 rs11954893 chr5:148392362 A/G cg12140854 chr5:148520817 ABLIM3 -0.42 -8.53 -0.32 1.06e-16 Breast cancer; BRCA trans rs7786808 0.653 rs7810861 chr7:158212633 G/A cg02030672 chr11:45687055 CHST1 0.47 10.63 0.39 2.04e-24 Obesity-related traits; BRCA cis rs1865760 0.865 rs9467645 chr6:25955176 G/C cg16482183 chr6:26056742 HIST1H1C 0.5 10.29 0.38 4.31e-23 Height; BRCA cis rs1003719 0.788 rs9977314 chr21:38471963 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.09 0.49 1.88e-39 Eye color traits; BRCA cis rs6558530 0.587 rs6986102 chr8:1700640 C/G cg19131313 chr8:1704013 NA -0.4 -8.03 -0.3 4.85e-15 Systolic blood pressure; BRCA cis rs4722585 0.605 rs3753098 chr7:26198040 C/T cg07876897 chr7:26191696 NFE2L3 -0.42 -9.18 -0.34 5.97e-19 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs514406 0.792 rs1242201 chr1:53344748 G/A cg27535305 chr1:53392650 SCP2 -0.4 -10.0 -0.37 5.49e-22 Monocyte count; BRCA trans rs11227306 0.934 rs11227315 chr11:65590389 C/A cg17712092 chr4:129076599 LARP1B 0.43 8.77 0.33 1.67e-17 DNA methylation (variation); BRCA cis rs4718428 0.705 rs10267335 chr7:66403220 G/T cg12165864 chr7:66369176 NA -0.44 -9.9 -0.36 1.33e-21 Corneal structure; BRCA cis rs829883 0.659 rs11109521 chr12:98930809 C/A cg25150519 chr12:98850993 NA -0.5 -9.1 -0.34 1.1e-18 Colorectal adenoma (advanced); BRCA cis rs2404602 0.536 rs7165025 chr15:76766434 G/A cg22467129 chr15:76604101 ETFA -0.49 -10.62 -0.39 2.22e-24 Blood metabolite levels; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg24642844 chr7:1081250 C7orf50 -0.89 -16.0 -0.53 1.07e-48 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7772486 0.875 rs2777483 chr6:146329235 A/G cg23711669 chr6:146136114 FBXO30 0.68 15.51 0.52 2.88e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs798554 0.610 rs2248390 chr7:2855594 T/C cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 8.91e-16 Height; BRCA cis rs3820928 0.874 rs4234063 chr2:227828335 A/T cg11843606 chr2:227700838 RHBDD1 0.39 8.64 0.32 4.4e-17 Pulmonary function; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg05279229 chr7:1896384 MAD1L1 -0.42 -8.35 -0.31 4.15e-16 Bipolar disorder and schizophrenia; BRCA cis rs9329289 0.610 rs10903783 chr10:2540623 C/T cg15501526 chr10:2543763 NA 0.44 10.19 0.37 1.04e-22 Age-related hearing impairment; BRCA cis rs7586879 0.598 rs6724772 chr2:25128730 T/C cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.3e-28 Body mass index; BRCA cis rs9733 0.519 rs7521898 chr1:150707596 G/A cg17724175 chr1:150552817 MCL1 0.25 8.36 0.31 3.79e-16 Tonsillectomy; BRCA cis rs1008375 1.000 rs56974987 chr4:17627856 G/A cg15017067 chr4:17643749 FAM184B 0.29 8.93 0.33 4.39e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1003719 0.788 rs13050757 chr21:38465345 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs3617 0.573 rs2336668 chr3:52919096 G/T cg11645453 chr3:52864694 ITIH4 -0.37 -9.76 -0.36 4.58e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs6484504 0.532 rs11031342 chr11:31309818 G/A cg06552810 chr11:31128660 NA -0.4 -8.89 -0.33 6.19e-18 Red blood cell count; BRCA cis rs7772486 0.790 rs7753092 chr6:146248863 C/T cg13319975 chr6:146136371 FBXO30 0.42 9.39 0.35 1.02e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs2415984 0.600 rs72672853 chr14:46932920 T/G cg14871534 chr14:47121158 RPL10L -0.37 -8.82 -0.33 1.12e-17 Number of children ever born; BRCA cis rs4665809 1.000 rs2384323 chr2:26306473 C/T cg25036284 chr2:26402008 FAM59B -0.64 -10.69 -0.39 1.22e-24 Gut microbiome composition (summer); BRCA cis rs72781680 0.560 rs111310684 chr2:24265682 C/G cg08917208 chr2:24149416 ATAD2B 0.57 9.07 0.34 1.43e-18 Lymphocyte counts; BRCA cis rs936229 0.749 rs8031937 chr15:75181121 A/G cg10253484 chr15:75165896 SCAMP2 -0.59 -11.45 -0.41 9.57e-28 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs1348850 0.914 rs11893448 chr2:178280013 T/C cg02961200 chr2:178257176 LOC100130691;AGPS 0.45 9.14 0.34 7.92e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs6479891 1.000 rs9415701 chr10:65151509 T/C cg14819942 chr15:35414228 NA 0.36 8.77 0.33 1.57e-17 Arthritis (juvenile idiopathic); BRCA cis rs1267303 0.675 rs1267312 chr1:46986748 C/G cg25110126 chr1:46999211 NA -0.5 -9.53 -0.35 3.34e-20 Monobrow; BRCA cis rs7707921 0.767 rs862245 chr5:81585737 A/C cg15871215 chr5:81402204 ATG10 -0.35 -8.18 -0.31 1.52e-15 Breast cancer; BRCA cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg14689365 chr7:158441557 NCAPG2 -0.42 -8.51 -0.32 1.2e-16 Height; BRCA cis rs10754283 0.967 rs10922679 chr1:90100925 T/C cg21401794 chr1:90099060 LRRC8C 0.46 11.31 0.41 3.76e-27 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg09436375 chr6:42928200 GNMT -0.29 -10.67 -0.39 1.46e-24 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1862618 0.853 rs190414 chr5:56116772 C/A cg12311346 chr5:56204834 C5orf35 -0.78 -15.35 -0.52 1.67e-45 Initial pursuit acceleration; BRCA cis rs7772486 0.719 rs702317 chr6:146005010 C/T cg13319975 chr6:146136371 FBXO30 0.39 9.02 0.34 2.21e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs9640161 0.750 rs73170185 chr7:150030191 C/A cg21361702 chr7:150065534 REPIN1 0.46 8.15 0.31 1.91e-15 Blood protein levels;Circulating chemerin levels; BRCA cis rs4074536 0.622 rs10754365 chr1:116325219 T/C cg21648376 chr1:116311395 CASQ2 -0.54 -8.81 -0.33 1.2e-17 QRS duration; BRCA trans rs561341 0.941 rs72825746 chr17:30364610 G/A cg27661571 chr11:113659931 NA -0.81 -11.96 -0.43 6.92e-30 Hip circumference adjusted for BMI; BRCA cis rs4665809 0.590 rs3792007 chr2:26497541 C/T cg22920501 chr2:26401640 FAM59B 0.94 16.34 0.54 1.98e-50 Gut microbiome composition (summer); BRCA cis rs6570726 0.764 rs4896821 chr6:145896181 G/A cg23711669 chr6:146136114 FBXO30 0.72 17.29 0.56 3.25e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg16414030 chr3:133502952 NA -0.48 -11.15 -0.4 1.69e-26 Iron status biomarkers; BRCA cis rs12142240 0.698 rs66911505 chr1:46823298 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.49 -0.35 4.68e-20 Menopause (age at onset); BRCA cis rs9341808 0.538 rs688867 chr6:80939228 A/G cg08355045 chr6:80787529 NA 0.32 7.83 0.3 1.99e-14 Sitting height ratio; BRCA cis rs6570726 0.791 rs6914203 chr6:145899975 C/A cg23711669 chr6:146136114 FBXO30 0.73 17.65 0.57 4.45e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.621 rs66828173 chr1:46818166 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs6912958 0.582 rs242285 chr6:88070743 G/A cg08069147 chr6:88032118 GJB7;C6orf162 0.63 13.13 0.46 5.15e-35 Monocyte percentage of white cells; BRCA cis rs13064411 0.696 rs6438161 chr3:113227637 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -12.22 -0.44 5.01e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg11752832 chr7:134001865 SLC35B4 0.53 13.58 0.47 4.23e-37 Mean platelet volume; BRCA cis rs9790314 0.779 rs1609688 chr3:160877096 T/G cg04691961 chr3:161091175 C3orf57 -0.49 -10.86 -0.39 2.38e-25 Morning vs. evening chronotype; BRCA trans rs1814175 0.502 rs12365889 chr11:49623034 G/A cg11707556 chr5:10655725 ANKRD33B -0.45 -10.07 -0.37 3.15e-22 Height; BRCA cis rs6138458 1.000 rs6114981 chr20:24974401 C/T cg06937882 chr20:24974362 C20orf3 0.46 9.24 0.34 3.72e-19 Blood protein levels; BRCA cis rs765787 0.530 rs1706837 chr15:45519036 A/G cg24006582 chr15:45444508 DUOX1 -0.55 -11.4 -0.41 1.58e-27 Uric acid levels; BRCA cis rs8180040 0.966 rs11130137 chr3:47578838 C/T cg27129171 chr3:47204927 SETD2 0.6 13.06 0.46 1.01e-34 Colorectal cancer; BRCA cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg02297831 chr4:17616191 MED28 0.37 8.58 0.32 6.97e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs921968 0.608 rs678814 chr2:219359287 T/C cg02176678 chr2:219576539 TTLL4 0.38 10.2 0.37 9.8e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs58235267 0.553 rs1025132 chr2:63360639 G/A cg17519650 chr2:63277830 OTX1 0.4 8.42 0.32 2.55e-16 Prostate-specific antigen levels (conditioned on lead SNPs); BRCA cis rs2075671 0.903 rs11983334 chr7:100302434 C/T cg16850897 chr7:100343110 ZAN -0.59 -12.54 -0.44 2.18e-32 Other erythrocyte phenotypes; BRCA cis rs4974559 0.739 rs6599298 chr4:1298122 A/G cg02980000 chr4:1222292 CTBP1 0.81 13.38 0.47 3.78e-36 Systolic blood pressure; BRCA cis rs35146811 0.695 rs858508 chr7:99821381 C/G cg13334819 chr7:99746414 C7orf59 0.39 9.01 0.34 2.32e-18 Coronary artery disease; BRCA cis rs6964587 0.933 rs10271174 chr7:91785970 A/G cg01689657 chr7:91764605 CYP51A1 0.23 8.32 0.31 5.44e-16 Breast cancer; BRCA cis rs735396 1.000 rs1169309 chr12:121439192 G/T cg02403541 chr12:121454288 C12orf43 0.54 10.04 0.37 4.14e-22 N-glycan levels; BRCA cis rs3936840 0.539 rs3742441 chr14:102970581 C/G cg18135206 chr14:102964638 TECPR2 0.45 8.61 0.32 5.48e-17 Plateletcrit; BRCA cis rs11051970 0.879 rs10844201 chr12:32575029 A/G cg02745156 chr12:32552066 NA 0.28 9.0 0.34 2.64e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6484504 0.576 rs208088 chr11:31192686 T/C cg14844989 chr11:31128820 NA -0.44 -9.52 -0.35 3.45e-20 Red blood cell count; BRCA cis rs10256972 0.786 rs3735686 chr7:1062527 G/A cg23978390 chr7:1156363 C7orf50 0.35 8.17 0.31 1.7e-15 Longevity;Endometriosis; BRCA cis rs490234 0.841 rs829314 chr9:128415506 A/T cg14078157 chr9:128172775 NA 0.33 7.87 0.3 1.47e-14 Mean arterial pressure; BRCA cis rs561341 1.000 rs72825740 chr17:30338356 A/G cg12193833 chr17:30244370 NA -0.56 -8.23 -0.31 1.03e-15 Hip circumference adjusted for BMI; BRCA trans rs61931739 0.500 rs7979482 chr12:34542877 C/A cg26384229 chr12:38710491 ALG10B 0.75 16.64 0.55 6.07e-52 Morning vs. evening chronotype; BRCA cis rs478304 0.934 rs506853 chr11:65521247 C/T cg08755490 chr11:65554678 OVOL1 0.52 10.88 0.4 2.11e-25 Acne (severe); BRCA cis rs4862750 0.872 rs6836781 chr4:187899701 G/A cg22105103 chr4:187893119 NA 0.41 13.27 0.46 1.16e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs6500602 0.674 rs8051695 chr16:4536621 T/C cg08645402 chr16:4508243 NA 0.38 8.99 0.34 2.74e-18 Schizophrenia; BRCA cis rs6121246 0.559 rs6087779 chr20:30370566 T/C cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs35740288 0.571 rs11633790 chr15:86326370 G/A cg20737812 chr15:86336631 KLHL25 -0.39 -9.27 -0.34 2.73e-19 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.92 -0.56 2.36e-53 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.666 rs2236665 chr21:45108987 C/A cg21573476 chr21:45109991 RRP1B -0.46 -12.0 -0.43 4.65e-30 Mean corpuscular volume; BRCA trans rs11252926 0.550 rs10795122 chr10:466830 C/T cg00953403 chr17:74099816 EXOC7 0.44 8.3 0.31 6.09e-16 Psychosis in Alzheimer's disease; BRCA cis rs10129255 0.530 rs11624912 chr14:107129907 A/G cg07958169 chr14:107095056 NA -0.38 -8.02 -0.3 4.93e-15 Kawasaki disease; BRCA cis rs12477438 0.520 rs6542865 chr2:99764521 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.64 0.39 1.8e-24 Chronic sinus infection; BRCA cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg04450456 chr4:17643702 FAM184B 0.37 11.05 0.4 4.1e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13046373 0.507 rs8133828 chr21:32033046 C/G cg14062083 chr21:31802829 KRTAP13-4 0.35 9.01 0.34 2.42e-18 HDL cholesterol; BRCA trans rs11764590 0.694 rs2056477 chr7:2079744 G/C cg11693508 chr17:37793320 STARD3 0.47 9.79 0.36 3.43e-21 Neuroticism; BRCA cis rs9329289 0.510 rs10903785 chr10:2550063 C/T cg15501526 chr10:2543763 NA 0.46 10.65 0.39 1.69e-24 Age-related hearing impairment; BRCA cis rs13256369 0.951 rs13259955 chr8:8565885 C/G cg17143192 chr8:8559678 CLDN23 0.56 10.96 0.4 1.01e-25 Obesity-related traits; BRCA cis rs6964587 1.000 rs9691325 chr7:91731047 G/A cg17063962 chr7:91808500 NA 0.53 12.57 0.45 1.52e-32 Breast cancer; BRCA trans rs1005277 0.579 rs2103938 chr10:38493998 T/G cg23533926 chr12:111358616 MYL2 -0.43 -9.06 -0.34 1.6e-18 Extrinsic epigenetic age acceleration; BRCA cis rs6952808 0.756 rs4719311 chr7:1881813 C/T cg02951883 chr7:2050386 MAD1L1 -0.38 -8.49 -0.32 1.4e-16 Bipolar disorder and schizophrenia; BRCA cis rs4908768 0.501 rs7551849 chr1:8539463 A/G cg20416874 chr1:8611966 RERE -0.29 -8.45 -0.32 1.93e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs7613875 0.620 rs7624030 chr3:50071279 A/C cg05623727 chr3:50126028 RBM5 -0.49 -11.71 -0.42 7.95e-29 Body mass index; BRCA cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg04166393 chr7:2884313 GNA12 0.41 8.74 0.33 1.98e-17 Height; BRCA cis rs4363385 0.818 rs4452994 chr1:152986871 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.91 -0.33 5.26e-18 Inflammatory skin disease; BRCA cis rs2832191 1.000 rs2832191 chr21:30489300 A/C cg24692254 chr21:30365293 RNF160 -0.58 -14.53 -0.5 1.62e-41 Dental caries; BRCA cis rs11098499 0.754 rs10213267 chr4:120239074 A/G cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA trans rs9409565 0.762 rs60964095 chr9:97175774 G/T cg05679027 chr9:99775184 HIATL2 -0.42 -9.27 -0.34 2.71e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs7523050 0.908 rs12036331 chr1:109398707 A/T cg08274380 chr1:109419600 GPSM2 0.75 11.68 0.42 1.05e-28 Fat distribution (HIV); BRCA cis rs4665809 1.000 rs6704930 chr2:26325705 G/A cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs6740322 0.696 rs10188539 chr2:43484675 G/C cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.75 -14.51 -0.5 1.92e-41 Coronary artery disease; BRCA cis rs7666738 0.962 rs2865986 chr4:99067907 A/G cg07917127 chr4:99064746 C4orf37 0.42 7.97 0.3 7.51e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs8141529 0.748 rs1318025 chr22:29283757 C/T cg02153584 chr22:29168773 CCDC117 0.52 10.8 0.39 4.38e-25 Lymphocyte counts; BRCA cis rs9354352 0.935 rs9354354 chr6:66699333 A/G cg07460842 chr6:66804631 NA -0.62 -13.48 -0.47 1.22e-36 Initial pursuit acceleration in psychotic disorders; BRCA cis rs477692 0.685 rs551491 chr10:131397821 G/A cg05714579 chr10:131428358 MGMT 0.53 12.05 0.43 2.88e-30 Response to temozolomide; BRCA cis rs11098499 0.909 rs11098530 chr4:120413154 C/T cg09307838 chr4:120376055 NA 0.72 15.26 0.52 4.91e-45 Corneal astigmatism; BRCA cis rs1348850 0.914 rs1453370 chr2:178327727 C/T cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 10.01 0.37 5.19e-22 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1707322 0.752 rs4586014 chr1:46150443 A/G cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.88e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 12.98 0.46 2.22e-34 Colorectal cancer; BRCA cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg23711669 chr6:146136114 FBXO30 0.8 19.0 0.6 4e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg20887711 chr4:1340912 KIAA1530 0.64 13.84 0.48 2.78e-38 Longevity; BRCA cis rs992157 1.000 rs2168704 chr2:219142492 G/A cg00012203 chr2:219082015 ARPC2 0.61 12.84 0.45 9.89e-34 Colorectal cancer; BRCA cis rs7666738 0.830 rs35235971 chr4:98999833 G/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.05 15.99 0.53 1.18e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9443645 0.901 rs1960542 chr6:79566643 C/T cg05283184 chr6:79620031 NA -0.44 -11.54 -0.42 4e-28 Intelligence (multi-trait analysis); BRCA cis rs2425143 1.000 rs11907811 chr20:34428078 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.81 -0.33 1.19e-17 Blood protein levels; BRCA cis rs208520 0.526 rs1385219 chr6:66754476 C/T cg07460842 chr6:66804631 NA 1.03 28.26 0.75 1.26e-114 Exhaled nitric oxide output; BRCA cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg23711669 chr6:146136114 FBXO30 0.71 17.11 0.56 2.46e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs9291683 0.588 rs35438220 chr4:9999398 C/T cg00071950 chr4:10020882 SLC2A9 0.6 14.67 0.5 3.44e-42 Bone mineral density; BRCA cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg14349672 chr11:133703707 NA -0.44 -9.7 -0.36 7.89e-21 Childhood ear infection; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg21280719 chr6:42927975 GNMT -0.31 -13.09 -0.46 7.62e-35 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6570726 0.764 rs9403733 chr6:145912311 A/C cg05347473 chr6:146136440 FBXO30 0.42 8.3 0.31 6.2e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs3780486 1.000 rs12342831 chr9:33124872 A/G cg20290983 chr6:43655470 MRPS18A 0.94 22.31 0.66 5.5e-82 IgG glycosylation; BRCA cis rs7659604 0.676 rs6855269 chr4:122697418 T/G cg19748678 chr4:122722346 EXOSC9 0.71 15.18 0.51 1.18e-44 Type 2 diabetes; BRCA cis rs7208859 0.673 rs73263776 chr17:29211331 G/C cg13385521 chr17:29058706 SUZ12P 0.63 8.58 0.32 7.12e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs6547741 1.000 rs4665381 chr2:27757150 A/C cg27432699 chr2:27873401 GPN1 0.47 10.09 0.37 2.63e-22 Oral cavity cancer; BRCA cis rs4665809 0.838 rs6546780 chr2:26352857 T/C cg04944784 chr2:26401820 FAM59B -0.67 -11.12 -0.4 2.21e-26 Gut microbiome composition (summer); BRCA trans rs8073060 0.586 rs8074800 chr17:33979148 A/G cg19694781 chr19:47549865 TMEM160 0.99 22.28 0.66 8.71e-82 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs155076 0.711 rs9550724 chr13:21885030 G/T cg21970626 chr13:21893289 NA -0.43 -8.91 -0.33 5.33e-18 White matter hyperintensity burden; BRCA cis rs6028335 0.610 rs12624839 chr20:37573816 G/A cg16355469 chr20:37678765 NA 0.44 8.07 0.3 3.62e-15 Alcohol and nicotine co-dependence; BRCA trans rs2840044 1.000 rs9891800 chr17:33895015 G/C cg19694781 chr19:47549865 TMEM160 0.46 10.92 0.4 1.37e-25 Response to radiotherapy in cancer (late toxicity); BRCA cis rs739401 0.611 rs450817 chr11:3056712 A/G cg08508325 chr11:3079039 CARS -0.43 -15.72 -0.53 2.64e-47 Longevity; BRCA cis rs34172651 0.876 rs964782 chr16:24811740 T/C cg00339695 chr16:24857497 SLC5A11 0.34 8.17 0.31 1.69e-15 Intelligence (multi-trait analysis); BRCA cis rs832540 0.552 rs252924 chr5:56205643 A/G cg24531977 chr5:56204891 C5orf35 -0.53 -10.86 -0.39 2.56e-25 Coronary artery disease; BRCA cis rs7918232 0.943 rs4747584 chr10:27373333 G/A cg14240646 chr10:27532245 ACBD5 -0.68 -10.46 -0.38 9.55e-24 Breast cancer; BRCA cis rs708547 0.647 rs2293175 chr4:57861358 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.43 11.87 0.43 1.63e-29 Response to bleomycin (chromatid breaks); BRCA cis rs2204008 0.744 rs8186814 chr12:38335169 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.26 0.56 4.56e-55 Bladder cancer; BRCA cis rs79976124 0.797 rs78317899 chr6:66652896 C/A cg07460842 chr6:66804631 NA 0.6 10.39 0.38 1.79e-23 Type 2 diabetes; BRCA cis rs10751667 0.666 rs7396509 chr11:956761 G/A cg10932868 chr11:921992 NA 0.49 12.5 0.44 3.11e-32 Alzheimer's disease (late onset); BRCA cis rs13108904 0.539 rs13145722 chr4:1338422 T/A cg13395646 chr4:1353034 KIAA1530 -0.5 -9.12 -0.34 9.35e-19 Obesity-related traits; BRCA cis rs8038465 0.662 rs57771618 chr15:73967578 T/C cg15420318 chr15:73925796 NPTN 0.39 8.47 0.32 1.7e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg05313129 chr8:58192883 C8orf71 -0.46 -9.59 -0.35 1.91e-20 Developmental language disorder (linguistic errors); BRCA cis rs6835098 1.000 rs6835098 chr4:174089238 T/C cg27433088 chr4:174089019 GALNT7 0.28 7.83 0.3 2.02e-14 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs6121246 0.909 rs8126355 chr20:30332660 C/T cg13852791 chr20:30311386 BCL2L1 0.84 16.5 0.55 3.24e-51 Mean corpuscular hemoglobin; BRCA cis rs514406 0.895 rs1925673 chr1:53326984 T/G cg24675658 chr1:53192096 ZYG11B -0.52 -11.39 -0.41 1.77e-27 Monocyte count; BRCA cis rs2576037 0.501 rs7227700 chr18:44537102 T/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.39 9.63 0.36 1.38e-20 Personality dimensions; BRCA cis rs2011503 1.000 rs2965179 chr19:19512755 G/A cg15839431 chr19:19639596 YJEFN3 -0.41 -9.13 -0.34 9.05e-19 Bipolar disorder; BRCA cis rs4948102 0.731 rs4689 chr7:56067016 G/T cg09872392 chr7:56161020 PHKG1 -0.39 -8.83 -0.33 9.76e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs1862618 0.853 rs11739344 chr5:56111087 A/C cg18230493 chr5:56204884 C5orf35 -0.73 -14.29 -0.49 2.21e-40 Initial pursuit acceleration; BRCA cis rs6866344 0.570 rs1071882 chr5:178136040 C/T cg03877680 chr5:178157825 ZNF354A 0.83 16.86 0.55 4.73e-53 Neutrophil percentage of white cells; BRCA cis rs6061231 0.624 rs8668 chr20:60964064 C/T cg22601191 chr20:60968625 CABLES2 -0.32 -7.99 -0.3 6.37e-15 Colorectal cancer; BRCA cis rs6089584 0.888 rs2146853 chr20:60617908 A/T cg13770153 chr20:60521292 NA -0.43 -9.51 -0.35 3.76e-20 Body mass index; BRCA cis rs8017423 0.630 rs4904678 chr14:90821670 T/C cg04374321 chr14:90722782 PSMC1 -0.49 -11.96 -0.43 6.75e-30 Mortality in heart failure; BRCA cis rs10465746 0.725 rs1359331 chr1:84360301 C/A cg10977910 chr1:84465055 TTLL7 0.6 12.8 0.45 1.53e-33 Obesity-related traits; BRCA cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg11644478 chr21:40555479 PSMG1 -0.51 -10.75 -0.39 6.88e-25 Menarche (age at onset); BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg19010396 chr19:19431384 KIAA0892;SF4 -0.45 -9.19 -0.34 5.35e-19 Tonsillectomy; BRCA cis rs9486719 1.000 rs3798296 chr6:97052286 G/A cg06623918 chr6:96969491 KIAA0776 -0.77 -13.59 -0.47 4.05e-37 Migraine;Coronary artery disease; BRCA cis rs4803468 1.000 rs284649 chr19:41926838 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -23.64 -0.68 3e-89 Height; BRCA cis rs7903847 0.620 rs2297988 chr10:99118382 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.06 -0.3 3.74e-15 Granulocyte percentage of myeloid white cells; BRCA trans rs61931739 0.500 rs7965421 chr12:34523624 G/T cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs2075371 1.000 rs1421484 chr7:133979795 T/C cg20476274 chr7:133979776 SLC35B4 0.7 21.36 0.65 8.17e-77 Mean platelet volume; BRCA cis rs9420 0.528 rs11229077 chr11:57399072 A/G cg19752551 chr11:57585705 CTNND1 0.37 9.42 0.35 8.33e-20 Schizophrenia; BRCA cis rs2635047 0.806 rs9962602 chr18:44599057 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.43 9.15 0.34 7.33e-19 Educational attainment; BRCA cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12756686 chr19:29218302 NA 0.57 10.98 0.4 8.46e-26 Methadone dose in opioid dependence; BRCA cis rs2836950 0.520 rs59916147 chr21:40634702 T/G cg22974920 chr21:40686053 BRWD1 -0.36 -8.15 -0.31 1.99e-15 Menarche (age at onset); BRCA cis rs2832077 0.527 rs1048546 chr21:30244877 G/T cg08807101 chr21:30365312 RNF160 -0.49 -10.97 -0.4 9.31e-26 Cognitive test performance; BRCA cis rs6089829 0.925 rs6062396 chr20:61667949 T/C cg02544614 chr20:61657117 NA 0.28 8.16 0.31 1.75e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs9790314 0.521 rs13084731 chr3:161086020 G/A cg03342759 chr3:160939853 NMD3 -0.56 -11.93 -0.43 9.38e-30 Morning vs. evening chronotype; BRCA cis rs6866344 0.570 rs1079487 chr5:178136005 G/A cg10224037 chr5:178157518 ZNF354A 0.79 18.23 0.58 4.46e-60 Neutrophil percentage of white cells; BRCA cis rs9814567 1.000 rs9827987 chr3:134272621 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.6 -20.03 -0.62 1.28e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs34172651 0.917 rs12923476 chr16:24798079 G/A cg00339695 chr16:24857497 SLC5A11 0.34 7.84 0.3 1.83e-14 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs4711101 chr6:25741970 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs4423214 0.840 rs1792226 chr11:71176574 C/T cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs12142240 0.660 rs6679080 chr1:46819779 A/T cg10495392 chr1:46806563 NSUN4 0.44 8.15 0.31 1.97e-15 Menopause (age at onset); BRCA trans rs66887589 0.560 rs9684327 chr4:120365441 A/G cg25214090 chr10:38739885 LOC399744 0.36 8.12 0.31 2.48e-15 Diastolic blood pressure; BRCA trans rs11039798 0.698 rs6485805 chr11:48101723 C/T cg15704280 chr7:45808275 SEPT13 0.56 7.89 0.3 1.36e-14 Axial length; BRCA cis rs7586879 0.681 rs6545800 chr2:25118885 A/G cg04586622 chr2:25135609 ADCY3 -0.47 -12.08 -0.43 2.17e-30 Body mass index; BRCA cis rs2842992 0.692 rs9347342 chr6:160193129 T/C cg11366901 chr6:160182831 ACAT2 0.69 13.46 0.47 1.54e-36 Age-related macular degeneration (geographic atrophy); BRCA cis rs12824058 0.831 rs12300308 chr12:130813825 G/A cg24229701 chr12:130821962 PIWIL1 0.39 8.91 0.33 5.31e-18 Menopause (age at onset); BRCA cis rs9487051 0.768 rs437779 chr6:109527691 T/G cg21918786 chr6:109611834 NA -0.34 -9.0 -0.34 2.53e-18 Reticulocyte fraction of red cells; BRCA cis rs2836974 0.863 rs8128026 chr21:40533702 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.38 0.76 1.05e-120 Cognitive function; BRCA cis rs4975616 0.804 rs457130 chr5:1336178 A/T cg26373071 chr5:1325741 CLPTM1L 0.45 10.58 0.39 3.32e-24 Lung cancer; BRCA cis rs798554 0.655 rs798492 chr7:2799184 C/T cg19717773 chr7:2847554 GNA12 0.42 9.42 0.35 7.91e-20 Height; BRCA cis rs769267 0.930 rs4808959 chr19:19572108 T/G cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.65 0.42 1.37e-28 Tonsillectomy; BRCA trans rs11098499 0.866 rs12510451 chr4:120289143 C/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs7264396 0.623 rs78949029 chr20:34384964 C/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.34 -0.38 2.79e-23 Total cholesterol levels; BRCA cis rs332507 0.830 rs3772789 chr3:124395607 A/G cg05980111 chr3:124395277 KALRN 0.38 8.58 0.32 6.93e-17 Plateletcrit; BRCA cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg18850127 chr7:39170497 POU6F2 0.54 11.9 0.43 1.27e-29 IgG glycosylation; BRCA cis rs2243480 0.522 rs431168 chr7:65511604 G/T cg18252515 chr7:66147081 NA -0.94 -10.48 -0.38 8.39e-24 Diabetic kidney disease; BRCA cis rs1790761 0.520 rs1551884 chr11:67399601 C/G cg24690094 chr11:67383802 NA -0.53 -11.14 -0.4 1.77e-26 Mean corpuscular volume; BRCA cis rs495337 0.720 rs6125819 chr20:48545710 T/C cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs9463078 0.770 rs9296453 chr6:45227432 C/T cg25276700 chr6:44698697 NA -0.35 -7.93 -0.3 1.01e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6963495 0.818 rs55825845 chr7:105166713 A/G cg19920283 chr7:105172520 RINT1 0.59 9.39 0.35 1.03e-19 Bipolar disorder (body mass index interaction); BRCA cis rs9325144 0.560 rs11183046 chr12:38655270 A/T cg13010199 chr12:38710504 ALG10B -0.38 -8.7 -0.33 2.89e-17 Morning vs. evening chronotype; BRCA cis rs4713118 0.869 rs9283883 chr6:27715470 T/A cg20933634 chr6:27740509 NA 0.45 9.0 0.34 2.5e-18 Parkinson's disease; BRCA cis rs1865721 1.000 rs3813080 chr18:73186227 C/T cg26385618 chr18:73139727 C18orf62 -0.41 -9.29 -0.34 2.46e-19 Intelligence; BRCA cis rs26949 0.503 rs1867702 chr5:59897983 T/C cg02684056 chr5:59996105 DEPDC1B 0.35 8.34 0.31 4.61e-16 Intelligence (multi-trait analysis); BRCA cis rs1448094 0.512 rs12314318 chr12:86249238 T/C cg19622623 chr12:86230825 RASSF9 -0.33 -9.38 -0.35 1.14e-19 Major depressive disorder; BRCA cis rs881375 0.678 rs1014530 chr9:123685092 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.57 0.32 7.63e-17 Rheumatoid arthritis; BRCA cis rs1691799 0.899 rs1168306 chr12:66738900 A/G cg16791601 chr12:66731901 HELB -0.64 -17.33 -0.57 2.02e-55 White blood cell count (basophil); BRCA cis rs4713118 0.513 rs149972 chr6:27983227 C/T cg10876282 chr6:28092338 ZSCAN16 0.41 8.0 0.3 5.69e-15 Parkinson's disease; BRCA cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg08807892 chr2:162101083 NA 0.49 9.78 0.36 3.7e-21 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.545 rs925828 chr12:39364222 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.41 0.35 8.87e-20 Morning vs. evening chronotype; BRCA cis rs17784882 0.521 rs11713693 chr3:47074906 T/C cg27129171 chr3:47204927 SETD2 -0.67 -15.32 -0.52 2.3e-45 QT interval; BRCA cis rs7555523 0.887 rs4269750 chr1:165711510 C/T cg24409356 chr1:165738333 TMCO1 0.51 8.21 0.31 1.23e-15 Intraocular pressure;Glaucoma (high intraocular pressure); BRCA cis rs208520 0.690 rs851465 chr6:66840293 G/A cg07460842 chr6:66804631 NA -1.02 -20.15 -0.62 2.95e-70 Exhaled nitric oxide output; BRCA cis rs2764980 1.000 rs11251794 chr10:3283931 C/T cg11630169 chr10:3283847 NA -0.41 -9.37 -0.35 1.18e-19 Attention deficit hyperactivity disorder and conduct disorder; BRCA trans rs6598955 0.671 rs12139514 chr1:26575939 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg26248373 chr2:1572462 NA -0.65 -15.81 -0.53 9.41e-48 IgG glycosylation; BRCA cis rs939658 0.805 rs35318825 chr15:79447098 C/A cg17916960 chr15:79447300 NA -0.48 -12.22 -0.44 5.09e-31 Refractive error; BRCA cis rs523522 0.962 rs2235218 chr12:120888619 A/C cg27279351 chr12:120934652 DYNLL1 0.51 12.19 0.43 6.77e-31 High light scatter reticulocyte count; BRCA cis rs597539 0.652 rs592697 chr11:68650064 G/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.75 18.19 0.58 7e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7666738 0.830 rs9999200 chr4:99030690 A/C cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.4 2.18e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs198389 0.589 rs535107 chr1:11889468 C/T cg24844545 chr1:11908347 NPPA 0.34 8.93 0.33 4.57e-18 B-type natriuretic peptide levels;NT-proBNP levels in acute coronary syndrome; BRCA cis rs4819052 0.766 rs4819035 chr21:46645715 A/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.57 10.74 0.39 7.28e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7249142 0.549 rs72997174 chr19:19294389 T/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.3 -0.31 6.24e-16 IgG glycosylation; BRCA cis rs1218582 0.741 rs6656494 chr1:154839799 A/G cg16680214 chr1:154839983 KCNN3 -0.4 -11.1 -0.4 2.61e-26 Prostate cancer; BRCA cis rs7662987 0.517 rs2851286 chr4:100014976 A/G cg12011299 chr4:100065546 ADH4 -0.48 -10.64 -0.39 1.94e-24 Smoking initiation; BRCA cis rs752010 0.655 rs10890145 chr1:42086290 A/G cg06885757 chr1:42089581 HIVEP3 0.3 10.7 0.39 1.06e-24 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs6479891 1.000 rs6479891 chr10:65006456 C/T cg14819942 chr15:35414228 NA 0.33 7.94 0.3 8.97e-15 Arthritis (juvenile idiopathic); BRCA cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.73 0.33 2.17e-17 Coronary artery disease; BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg09060608 chr5:178986726 RUFY1 0.62 16.03 0.54 7.32e-49 Lung cancer; BRCA cis rs35995292 0.534 rs2008199 chr7:38939678 T/C cg19327137 chr7:38886074 VPS41 0.4 13.2 0.46 2.26e-35 Subjective well-being (multi-trait analysis); BRCA cis rs17818399 0.962 rs2122715 chr2:46845849 A/G cg02822958 chr2:46747628 ATP6V1E2 0.52 10.09 0.37 2.68e-22 Height; BRCA cis rs11711311 1.000 rs1043132 chr3:113528689 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.89 -0.36 1.54e-21 IgG glycosylation; BRCA cis rs208520 0.661 rs704519 chr6:66801136 T/C cg07460842 chr6:66804631 NA -1.0 -19.95 -0.62 3.32e-69 Exhaled nitric oxide output; BRCA cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg25554036 chr4:6271136 WFS1 0.42 9.91 0.37 1.19e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7587476 0.906 rs16852750 chr2:215646683 A/G cg04004882 chr2:215674386 BARD1 0.59 10.38 0.38 1.97e-23 Neuroblastoma; BRCA trans rs1493916 0.837 rs9949631 chr18:31410567 G/A cg27147174 chr7:100797783 AP1S1 -0.42 -8.48 -0.32 1.55e-16 Life satisfaction; BRCA trans rs7944735 0.517 rs7952205 chr11:48199227 A/G cg03929089 chr4:120376271 NA 0.51 7.85 0.3 1.75e-14 Intraocular pressure; BRCA cis rs6942756 0.806 rs6467240 chr7:128984018 T/C cg02491457 chr7:128862824 NA -0.58 -12.25 -0.44 3.93e-31 White matter hyperintensity burden; BRCA cis rs7618915 0.571 rs17264436 chr3:52610651 T/A cg10802521 chr3:52805072 NEK4 -0.32 -8.33 -0.31 5.11e-16 Bipolar disorder; BRCA cis rs1008375 0.932 rs3846356 chr4:17614176 C/T cg15017067 chr4:17643749 FAM184B 0.29 8.98 0.33 3.08e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs11764590 0.671 rs62444906 chr7:2083161 G/T cg11693508 chr17:37793320 STARD3 0.53 8.98 0.33 3.03e-18 Neuroticism; BRCA cis rs765787 0.530 rs11070451 chr15:45533541 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.1 0.31 2.78e-15 Uric acid levels; BRCA cis rs2346177 0.519 rs13003074 chr2:46671420 A/T cg02822958 chr2:46747628 ATP6V1E2 -0.5 -9.9 -0.36 1.33e-21 HDL cholesterol; BRCA cis rs651907 0.535 rs4342086 chr3:101503765 G/A cg12386194 chr3:101231763 SENP7 0.46 9.79 0.36 3.57e-21 Colorectal cancer; BRCA cis rs10751667 0.714 rs7395879 chr11:963855 G/C cg01483505 chr11:975446 AP2A2 0.33 9.05 0.34 1.7e-18 Alzheimer's disease (late onset); BRCA cis rs2882667 0.898 rs12719519 chr5:138375687 G/A cg04439458 chr5:138467593 SIL1 -0.32 -8.94 -0.33 4.18e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs780096 0.546 rs2911712 chr2:27626945 A/T cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.62 -0.32 5.35e-17 Total body bone mineral density; BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg00814883 chr7:100076585 TSC22D4 -0.54 -10.6 -0.39 2.74e-24 Platelet count; BRCA cis rs9443645 0.901 rs971994 chr6:79559602 G/C cg11833968 chr6:79620685 NA -0.44 -9.95 -0.37 9.12e-22 Intelligence (multi-trait analysis); BRCA cis rs4237845 0.761 rs11172378 chr12:58298161 C/T cg00677455 chr12:58241039 CTDSP2 0.57 13.56 0.47 5.32e-37 Intelligence (multi-trait analysis); BRCA cis rs561341 1.000 rs550264 chr17:30317540 G/T cg12193833 chr17:30244370 NA -0.56 -8.77 -0.33 1.58e-17 Hip circumference adjusted for BMI; BRCA cis rs6582630 0.555 rs1829583 chr12:38423161 T/C cg26384229 chr12:38710491 ALG10B -0.62 -14.76 -0.5 1.21e-42 Drug-induced liver injury (flucloxacillin); BRCA cis rs2280018 0.526 rs1510148 chr16:15167379 T/A cg07549590 chr16:15018862 NA -0.49 -12.27 -0.44 3.16e-31 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs3858526 0.883 rs4758183 chr11:5925178 C/G cg25319279 chr11:5960081 NA -0.4 -7.9 -0.3 1.23e-14 DNA methylation (variation); BRCA cis rs7246657 0.943 rs7253091 chr19:37967214 C/T cg23950597 chr19:37808831 NA -0.61 -11.53 -0.41 4.51e-28 Coronary artery calcification; BRCA cis rs6701037 0.681 rs1057246 chr1:175127534 C/G cg14847009 chr1:175162515 KIAA0040 0.25 9.52 0.35 3.52e-20 Alcohol dependence; BRCA cis rs12579753 0.913 rs7965664 chr12:82237340 G/T cg07988820 chr12:82153109 PPFIA2 -0.64 -10.56 -0.39 4.07e-24 Resting heart rate; BRCA cis rs4819052 0.851 rs35560973 chr21:46662573 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.43 8.27 0.31 7.97e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs9409565 0.821 rs7858082 chr9:97063929 T/A cg05679027 chr9:99775184 HIATL2 0.41 9.08 0.34 1.33e-18 Colorectal cancer (alcohol consumption interaction); BRCA cis rs765787 0.530 rs12904265 chr15:45526713 C/T cg15395560 chr15:45543142 SLC28A2 -0.29 -7.82 -0.3 2.22e-14 Uric acid levels; BRCA cis rs9309473 1.000 rs6711033 chr2:73746643 T/C cg20560298 chr2:73613845 ALMS1 -0.41 -10.15 -0.37 1.54e-22 Metabolite levels; BRCA cis rs4072980 0.524 rs16824514 chr1:38395947 A/T cg26398791 chr1:38455867 SF3A3 -0.4 -8.27 -0.31 7.58e-16 Coronary artery disease; BRCA cis rs4727027 0.704 rs13229244 chr7:148898219 A/C cg23583168 chr7:148888333 NA 0.95 24.57 0.7 2.32e-94 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs7618501 1.000 rs34451146 chr3:49813013 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.54 16.92 0.56 2.48e-53 Intelligence (multi-trait analysis); BRCA cis rs11229555 0.645 rs7947248 chr11:58197750 C/T cg15696309 chr11:58395628 NA -0.52 -10.83 -0.39 3.19e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1707322 0.964 rs1768802 chr1:46547868 A/G cg06784218 chr1:46089804 CCDC17 -0.44 -10.47 -0.38 8.95e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12048904 0.647 rs7528268 chr1:101329295 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 0.52 11.68 0.42 1.02e-28 Multiple sclerosis; BRCA cis rs7811142 0.943 rs28660238 chr7:100023308 C/T cg11814155 chr7:99998594 ZCWPW1 0.42 8.0 0.3 5.84e-15 Platelet count; BRCA cis rs780096 0.526 rs12476704 chr2:27613031 C/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.95 -0.3 8.36e-15 Total body bone mineral density; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg25036284 chr2:26402008 FAM59B -0.88 -15.06 -0.51 4.18e-44 Gut microbiome composition (summer); BRCA trans rs9388451 0.807 rs1268070 chr6:126041164 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.45 -10.07 -0.37 2.96e-22 Brugada syndrome; BRCA cis rs17604090 0.818 rs73090342 chr7:29687540 T/C cg19413766 chr7:29689036 LOC646762 -0.59 -8.17 -0.31 1.67e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs909002 0.849 rs10914453 chr1:32075036 A/G cg13919466 chr1:32135498 COL16A1 -0.26 -8.74 -0.33 2e-17 Intelligence (multi-trait analysis); BRCA cis rs4803468 1.000 rs10413735 chr19:41921071 C/T cg09537434 chr19:41945824 ATP5SL -1.0 -23.92 -0.69 8.58e-91 Height; BRCA trans rs11039798 1.000 rs7123704 chr11:48580535 G/A cg15704280 chr7:45808275 SEPT13 0.55 8.25 0.31 9.34e-16 Axial length; BRCA cis rs143626010 1 rs143626010 chr16:28539398 GTGTA/G cg16576597 chr16:28551801 NUPR1 0.35 9.41 0.35 8.46e-20 Mosquito bite size; BRCA trans rs66887589 0.592 rs62320740 chr4:120279486 C/A cg25214090 chr10:38739885 LOC399744 0.37 8.73 0.33 2.16e-17 Diastolic blood pressure; BRCA cis rs67311347 1.000 rs112619360 chr3:40432645 T/G cg01475735 chr3:40494733 NA -0.39 -7.98 -0.3 6.97e-15 Renal cell carcinoma; BRCA trans rs634534 0.561 rs613924 chr11:65769295 C/T cg17712092 chr4:129076599 LARP1B 0.56 13.49 0.47 1.07e-36 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.5 0.5 2.04e-41 Colorectal cancer; BRCA trans rs3812049 0.737 rs1112956 chr5:127433798 C/T cg16011800 chr17:1958478 HIC1 0.51 8.4 0.32 2.95e-16 Lymphocyte counts;Red cell distribution width; BRCA cis rs870825 0.655 rs12502771 chr4:185635834 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.58e-56 Blood protein levels; BRCA cis rs7809950 1.000 rs2712189 chr7:107195747 G/A cg23024343 chr7:107201750 COG5 -0.4 -9.08 -0.34 1.32e-18 Coronary artery disease; BRCA cis rs4363385 0.747 rs4568784 chr1:152972694 G/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.71 -0.36 7.26e-21 Inflammatory skin disease; BRCA cis rs875971 1.000 rs12532998 chr7:65967459 A/C cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.75e-66 Aortic root size; BRCA cis rs2204008 0.774 rs12810027 chr12:38212165 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.9e-22 Bladder cancer; BRCA cis rs4363385 0.747 rs4314835 chr1:152984901 C/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.2 -0.34 5.11e-19 Inflammatory skin disease; BRCA cis rs10197940 0.662 rs10175134 chr2:152299355 G/A cg06191203 chr2:152266755 RIF1 -0.42 -12.15 -0.43 1.02e-30 Lung cancer; BRCA cis rs4665809 0.652 rs2241739 chr2:26411894 C/T cg27170947 chr2:26402098 FAM59B -0.87 -16.7 -0.55 3.29e-52 Gut microbiome composition (summer); BRCA trans rs11098499 0.821 rs10032151 chr4:120391628 C/T cg25517755 chr10:38738941 LOC399744 -0.37 -7.81 -0.3 2.32e-14 Corneal astigmatism; BRCA cis rs9368481 0.594 rs7768814 chr6:26892036 C/A cg18867708 chr6:26865862 GUSBL1 0.42 8.27 0.31 7.7e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6840360 0.615 rs9996320 chr4:152610587 T/G cg22705602 chr4:152727874 NA -0.37 -10.16 -0.37 1.37e-22 Intelligence (multi-trait analysis); BRCA cis rs17685 0.753 rs6951943 chr7:75772452 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.51 -0.32 1.28e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs992157 0.731 rs1399132 chr2:219159770 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.53 11.89 0.43 1.37e-29 Colorectal cancer; BRCA cis rs4148883 0.504 rs28720150 chr4:100132790 T/G cg12011299 chr4:100065546 ADH4 -0.38 -11.0 -0.4 7.09e-26 Alcohol dependence; BRCA cis rs4900538 0.928 rs1190551 chr14:102911508 A/G cg18135206 chr14:102964638 TECPR2 -1.06 -29.82 -0.76 4.06e-123 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs1371614 0.632 rs7599286 chr2:27152398 T/C cg00617064 chr2:27272375 NA -0.31 -7.98 -0.3 6.97e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA trans rs10838798 0.504 rs11039634 chr11:48297843 A/G cg00717180 chr2:96193071 NA -0.38 -10.14 -0.37 1.71e-22 Height; BRCA cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg13319975 chr6:146136371 FBXO30 -0.39 -8.85 -0.33 8.79e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs9640161 0.750 rs3800780 chr7:150027284 C/A cg12556325 chr7:150026731 C7orf29;LRRC61 -0.56 -13.6 -0.47 3.46e-37 Blood protein levels;Circulating chemerin levels; BRCA cis rs9359856 0.564 rs72915903 chr6:90420190 A/C cg13799429 chr6:90582589 CASP8AP2 -0.65 -8.15 -0.31 1.94e-15 Bipolar disorder; BRCA cis rs4665809 0.938 rs35844686 chr2:26304949 A/G cg04944784 chr2:26401820 FAM59B 0.82 11.19 0.4 1.11e-26 Gut microbiome composition (summer); BRCA cis rs6963495 0.818 rs17343556 chr7:105151272 C/T cg19920283 chr7:105172520 RINT1 0.58 9.39 0.35 1.01e-19 Bipolar disorder (body mass index interaction); BRCA cis rs514406 0.679 rs545719 chr1:53304922 T/C cg27535305 chr1:53392650 SCP2 -0.49 -11.92 -0.43 9.67e-30 Monocyte count; BRCA cis rs2011503 1.000 rs2965181 chr19:19512317 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.29 -0.34 2.38e-19 Bipolar disorder; BRCA cis rs78456975 1.000 rs13413096 chr2:1553588 G/A cg12573674 chr2:1569213 NA -0.49 -9.34 -0.35 1.58e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7762018 1.000 rs73242927 chr6:170129573 T/A cg19338460 chr6:170058176 WDR27 -0.44 -7.83 -0.3 1.99e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs2404602 0.716 rs284895 chr15:76751225 C/G cg26408565 chr15:76604113 ETFA 0.45 9.68 0.36 9.08e-21 Blood metabolite levels; BRCA cis rs12477438 0.501 rs13000731 chr2:99795231 G/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.5 0.63 3.81e-72 Chronic sinus infection; BRCA cis rs637571 0.546 rs11227311 chr11:65585257 C/A cg26695010 chr11:65641043 EFEMP2 0.37 7.98 0.3 6.86e-15 Eosinophil percentage of white cells; BRCA cis rs10046574 0.831 rs7780345 chr7:135137731 T/C cg27474649 chr7:135195673 CNOT4 0.61 8.64 0.32 4.59e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9811920 0.535 rs704572 chr3:99482314 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -9.24 -0.34 3.56e-19 Axial length; BRCA cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg02951883 chr7:2050386 MAD1L1 -0.48 -11.4 -0.41 1.57e-27 Schizophrenia; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg03354898 chr7:1950403 MAD1L1 -0.5 -10.48 -0.38 7.95e-24 Bipolar disorder and schizophrenia; BRCA cis rs7246657 0.943 rs10409204 chr19:37917692 G/A cg23950597 chr19:37808831 NA -0.74 -13.0 -0.46 1.93e-34 Coronary artery calcification; BRCA cis rs853679 0.569 rs9348798 chr6:28143011 G/A cg18032046 chr6:28092343 ZSCAN16 -0.51 -8.1 -0.31 2.84e-15 Depression; BRCA trans rs629535 0.665 rs2433331 chr8:70041943 T/C cg21567404 chr3:27674614 NA 0.99 21.48 0.65 1.92e-77 Dupuytren's disease; BRCA trans rs6089829 0.926 rs1060489 chr20:61665921 C/T cg17470723 chr8:74884337 TCEB1 0.4 8.68 0.32 3.22e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs10504229 0.683 rs7816733 chr8:58129855 G/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs4663866 0.901 rs71426512 chr2:239187128 C/T cg16914508 chr2:239161102 PER2 0.7 9.49 0.35 4.42e-20 Irritable bowel syndrome; BRCA trans rs1493916 0.777 rs1941685 chr18:31304318 G/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.41 -0.32 2.72e-16 Life satisfaction; BRCA cis rs9311474 0.508 rs6805156 chr3:52609362 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.18 0.46 2.94e-35 Electroencephalogram traits; BRCA cis rs2980439 0.818 rs2948294 chr8:8094961 A/G cg08975724 chr8:8085496 FLJ10661 0.54 11.13 0.4 1.94e-26 Neuroticism; BRCA cis rs7267979 1.000 rs4813566 chr20:25386465 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.06 -0.34 1.53e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4711336 0.809 rs749338 chr6:33653448 A/G cg14003231 chr6:33640908 ITPR3 -0.36 -9.18 -0.34 6.15e-19 Height; BRCA cis rs4642101 0.628 rs1003080 chr3:12811628 C/T cg24848339 chr3:12840334 CAND2 -0.36 -9.54 -0.35 2.84e-20 QRS complex (12-leadsum); BRCA cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg11833968 chr6:79620685 NA -0.42 -9.35 -0.35 1.46e-19 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24531977 chr5:56204891 C5orf35 -0.87 -19.01 -0.6 3.29e-64 Initial pursuit acceleration; BRCA cis rs9811920 0.683 rs793439 chr3:99637783 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.47 11.22 0.41 8.46e-27 Axial length; BRCA cis rs3733585 0.579 rs4235353 chr4:10122934 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -9.85 -0.36 2.07e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6582630 0.555 rs34145279 chr12:38405588 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.16 0.37 1.4e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs8072100 0.967 rs8072644 chr17:45653364 A/T cg19784903 chr17:45786737 TBKBP1 0.33 7.98 0.3 6.69e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs8028182 0.636 rs12708520 chr15:75830539 C/T cg20655648 chr15:75932815 IMP3 0.42 8.27 0.31 8e-16 Sudden cardiac arrest; BRCA cis rs4930561 0.765 rs34493482 chr11:67969508 T/C cg16338278 chr11:67432957 ALDH3B2 0.44 8.97 0.33 3.37e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs736408 0.812 rs1075653 chr3:52825528 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.32 10.27 0.38 5.1e-23 Bipolar disorder; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.03 22.67 0.67 5.83e-84 Gut microbiome composition (summer); BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg00106254 chr7:1943704 MAD1L1 -0.4 -10.71 -0.39 9.92e-25 Bipolar disorder and schizophrenia; BRCA cis rs8114671 0.836 rs6141526 chr20:33615255 G/T cg07148914 chr20:33460835 GGT7 -0.42 -8.95 -0.33 3.92e-18 Height; BRCA cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg24006582 chr15:45444508 DUOX1 -0.55 -11.32 -0.41 3.19e-27 Uric acid levels; BRCA cis rs1865760 0.929 rs1816546 chr6:25938252 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 9.99 0.37 6.38e-22 Height; BRCA cis rs752010 0.695 rs10789407 chr1:42106538 G/T cg06885757 chr1:42089581 HIVEP3 0.23 8.35 0.31 4.34e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs3768617 0.528 rs10737242 chr1:183098249 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs875971 0.545 rs73142233 chr7:65686280 T/A cg11764359 chr7:65958608 NA 0.63 10.84 0.39 2.88e-25 Aortic root size; BRCA cis rs12612619 0.579 rs41448746 chr2:27080706 A/G cg08802533 chr2:27073253 DPYSL5 -0.29 -7.87 -0.3 1.55e-14 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs17401966 0.838 rs4529713 chr1:10307295 A/G cg03954927 chr1:10346856 KIF1B 0.43 13.72 0.48 1.01e-37 Hepatocellular carcinoma; BRCA cis rs3784262 0.643 rs8030766 chr15:58369209 A/G cg12031962 chr15:58353849 ALDH1A2 0.37 9.19 0.34 5.52e-19 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7772486 0.686 rs6933161 chr6:146081369 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -16.77 -0.55 1.44e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs681343 0.746 rs633372 chr19:49209226 G/A cg21064579 chr19:49206444 FUT2 0.32 8.02 0.3 4.92e-15 Lung adenocarcinoma;Primary sclerosing cholangitis;Childhood ear infection; BRCA cis rs2576037 0.796 rs2576043 chr18:44573476 C/G cg19077165 chr18:44547161 KATNAL2 0.38 8.1 0.31 2.88e-15 Personality dimensions; BRCA cis rs853679 0.517 rs4713148 chr6:28115921 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Depression; BRCA cis rs1003719 0.688 rs2835662 chr21:38568967 T/A cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.73 -0.5 1.77e-42 Eye color traits; BRCA cis rs7786877 0.723 rs11764045 chr7:100212754 C/T cg16850897 chr7:100343110 ZAN -0.57 -10.66 -0.39 1.57e-24 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs9814567 1.000 rs7428326 chr3:134251184 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6701037 0.748 rs2685 chr1:175127771 A/G cg00321850 chr1:175162397 KIAA0040 0.41 11.39 0.41 1.65e-27 Alcohol dependence; BRCA cis rs495337 0.760 rs2769982 chr20:48524827 C/T cg17835207 chr20:48524531 SPATA2 0.67 16.76 0.55 1.59e-52 Psoriasis; BRCA cis rs7975161 0.565 rs4545635 chr12:104636844 A/C cg25273343 chr12:104657179 TXNRD1 -0.63 -9.75 -0.36 4.9e-21 Toenail selenium levels; BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg08470875 chr2:26401718 FAM59B 0.71 11.35 0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs897080 0.515 rs786617 chr2:44593158 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.57 11.04 0.4 4.53e-26 Height; BRCA cis rs2404602 0.536 rs7163946 chr15:76766049 C/G cg26408565 chr15:76604113 ETFA -0.48 -10.32 -0.38 3.37e-23 Blood metabolite levels; BRCA cis rs2404602 0.647 rs10851892 chr15:77176491 T/C cg23625390 chr15:77176239 SCAPER -0.55 -12.95 -0.46 3.28e-34 Blood metabolite levels; BRCA cis rs12950390 0.853 rs4794107 chr17:45843159 T/G cg24803719 chr17:45855879 NA -0.32 -8.4 -0.32 2.93e-16 IgG glycosylation; BRCA cis rs2836974 0.897 rs2836932 chr21:40546717 G/A cg11890956 chr21:40555474 PSMG1 1.04 29.55 0.76 1.3e-121 Cognitive function; BRCA cis rs6598955 0.543 rs61608823 chr1:26555090 G/A cg12744634 chr1:26560303 CCDC21 0.3 7.88 0.3 1.46e-14 Obesity-related traits; BRCA cis rs2832191 0.716 rs2692625 chr21:30446360 C/G cg24692254 chr21:30365293 RNF160 0.78 21.75 0.65 6.72e-79 Dental caries; BRCA cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg07414643 chr4:187882934 NA -0.26 -9.15 -0.34 7.66e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs6598955 0.671 rs13374173 chr1:26602256 T/G cg04990556 chr1:26633338 UBXN11 0.54 8.78 0.33 1.52e-17 Obesity-related traits; BRCA cis rs738322 0.934 rs133019 chr22:38573035 A/G cg20207973 chr22:38506712 BAIAP2L2 0.31 7.86 0.3 1.66e-14 Cutaneous nevi; BRCA cis rs2075371 1.000 rs447266 chr7:133989543 A/G cg20476274 chr7:133979776 SLC35B4 0.62 18.01 0.58 6.11e-59 Mean platelet volume; BRCA cis rs10206020 0.885 rs13388254 chr2:1577209 A/G cg12573674 chr2:1569213 NA -0.58 -12.54 -0.44 2.11e-32 IgG glycosylation; BRCA cis rs1801251 1.000 rs71421663 chr2:233619131 A/G cg08000102 chr2:233561755 GIGYF2 0.64 13.9 0.48 1.5e-38 Coronary artery disease; BRCA cis rs7246657 1.000 rs35398388 chr19:37740358 A/G cg23950597 chr19:37808831 NA -0.65 -11.1 -0.4 2.75e-26 Coronary artery calcification; BRCA cis rs9443645 0.901 rs9361460 chr6:79589467 C/G cg05283184 chr6:79620031 NA -0.43 -11.22 -0.41 8.77e-27 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.527 rs10943588 chr6:79510994 A/C cg05283184 chr6:79620031 NA -0.36 -8.32 -0.31 5.43e-16 Intelligence (multi-trait analysis); BRCA cis rs897984 0.542 rs11864839 chr16:31095251 G/C cg02466173 chr16:30829666 NA -0.44 -9.87 -0.36 1.81e-21 Dementia with Lewy bodies; BRCA cis rs2070488 1.000 rs4147024 chr3:38456664 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.56 0.61 4.15e-67 Electrocardiographic conduction measures; BRCA trans rs1459104 0.706 rs35228933 chr11:55027673 G/A cg15704280 chr7:45808275 SEPT13 0.7 8.64 0.32 4.37e-17 Body mass index; BRCA cis rs9287719 0.967 rs4519489 chr2:10739087 A/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg25767906 chr1:53392781 SCP2 0.34 7.9 0.3 1.18e-14 Monocyte count; BRCA cis rs1843834 0.539 rs10177898 chr2:225437552 C/T cg12698349 chr2:225449008 CUL3 0.61 13.46 0.47 1.49e-36 IgE levels in asthmatics (D.p. specific); BRCA cis rs9287719 0.935 rs1309 chr2:10743546 A/G cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs6450176 1.000 rs3776718 chr5:53298714 G/C ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.71e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs796364 0.951 rs12463436 chr2:201061962 C/G cg23649088 chr2:200775458 C2orf69 0.61 10.53 0.38 5.32e-24 Schizophrenia; BRCA cis rs7254827 0.737 rs12973050 chr19:17174261 G/C cg19418318 chr19:17219073 MYO9B -0.48 -10.03 -0.37 4.26e-22 Mean platelet volume; BRCA trans rs17685 0.784 rs1637043 chr7:75699099 G/A cg19862616 chr7:65841803 NCRNA00174 0.86 28.66 0.75 8.26e-117 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6570726 0.935 rs401888 chr6:145831535 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs10129255 0.518 rs10136903 chr14:107187105 T/C cg07958169 chr14:107095056 NA -0.39 -8.29 -0.31 6.7e-16 Kawasaki disease; BRCA cis rs2204008 0.811 rs11520277 chr12:38359611 G/A cg26384229 chr12:38710491 ALG10B 0.69 16.21 0.54 9.67e-50 Bladder cancer; BRCA cis rs7646881 0.767 rs73015669 chr3:158456318 C/A cg19483011 chr3:158453295 NA -0.47 -8.3 -0.31 6.28e-16 Tetralogy of Fallot; BRCA cis rs425277 0.606 rs262664 chr1:2083537 G/C cg24578937 chr1:2090814 PRKCZ 0.38 11.67 0.42 1.14e-28 Height; BRCA cis rs7927771 0.832 rs11601173 chr11:47401058 A/G cg20307385 chr11:47447363 PSMC3 -0.4 -8.48 -0.32 1.52e-16 Subjective well-being; BRCA cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg16325326 chr1:53192061 ZYG11B -0.71 -18.74 -0.6 8.49e-63 Monocyte count; BRCA cis rs7103648 0.838 rs2293576 chr11:47434986 A/G cg20307385 chr11:47447363 PSMC3 -0.82 -20.74 -0.63 1.95e-73 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg19077165 chr18:44547161 KATNAL2 -0.59 -13.39 -0.47 3.24e-36 Personality dimensions; BRCA cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg24675658 chr1:53192096 ZYG11B 0.83 18.88 0.6 1.69e-63 Monocyte count; BRCA cis rs4494114 0.967 rs9438980 chr1:39355371 A/G cg25970120 chr1:39325951 RRAGC -0.37 -7.92 -0.3 1.03e-14 Blood protein levels; BRCA cis rs4363385 0.747 rs2339494 chr1:152975143 G/C cg21543102 chr1:152974771 SPRR3 -0.3 -8.31 -0.31 5.88e-16 Inflammatory skin disease; BRCA cis rs11051970 0.879 rs2651379 chr12:32581778 A/G cg02745156 chr12:32552066 NA 0.27 8.93 0.33 4.43e-18 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs17685 0.753 rs6976532 chr7:75681094 A/G cg19862616 chr7:65841803 NCRNA00174 0.86 28.4 0.75 2.15e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6772849 0.896 rs4857859 chr3:128348014 G/T cg16766828 chr3:128327626 NA -0.39 -8.74 -0.33 2.11e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg06221963 chr1:154839813 KCNN3 -0.56 -15.69 -0.53 3.45e-47 Prostate cancer; BRCA cis rs60843830 1.000 rs4497901 chr2:239969 C/T cg00108164 chr2:264199 ACP1;SH3YL1 0.7 14.78 0.5 9.37e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4819052 0.851 rs7276828 chr21:46695039 T/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs16958440 1.000 rs16958432 chr18:44631773 G/A cg17192377 chr18:44677553 HDHD2 0.67 9.75 0.36 4.96e-21 Sitting height ratio; BRCA cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg10523679 chr1:76189770 ACADM 0.77 15.59 0.52 1.18e-46 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9649465 1.000 rs11770041 chr7:123365788 C/T cg04330084 chr7:123175371 IQUB -0.33 -9.08 -0.34 1.33e-18 Migraine; BRCA cis rs6973256 0.897 rs7777805 chr7:133337074 T/C cg07491979 chr7:133331646 EXOC4 -0.39 -8.9 -0.33 5.64e-18 Intelligence (multi-trait analysis); BRCA cis rs12410462 0.792 rs994666 chr1:227651454 C/T cg04117972 chr1:227635322 NA -0.46 -8.31 -0.31 5.86e-16 Major depressive disorder; BRCA cis rs9399135 0.967 rs4896121 chr6:135293645 T/C cg24558204 chr6:135376177 HBS1L 0.47 12.75 0.45 2.45e-33 Red blood cell count; BRCA cis rs9457247 0.534 rs933243 chr6:167403873 A/C cg00271210 chr6:167070053 RPS6KA2 -0.31 -8.06 -0.3 3.69e-15 Crohn's disease; BRCA cis rs6866344 0.570 rs4266420 chr5:178137161 C/G cg03877680 chr5:178157825 ZNF354A 0.84 17.0 0.56 9.13e-54 Neutrophil percentage of white cells; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg07092213 chr7:1199455 ZFAND2A -0.5 -10.76 -0.39 6.5e-25 Longevity;Endometriosis; BRCA cis rs2386661 0.522 rs11258033 chr10:5644372 C/T cg17085576 chr10:5658249 NA 0.31 8.04 0.3 4.39e-15 Breast cancer; BRCA cis rs12971120 0.891 rs12608037 chr18:72169395 A/G cg25817165 chr18:72167213 CNDP2 -0.77 -14.27 -0.49 2.52e-40 Refractive error; BRCA cis rs2806561 0.808 rs2235546 chr1:23409538 A/G cg19743168 chr1:23544995 NA 0.38 8.37 0.31 3.73e-16 Height; BRCA cis rs6733011 0.578 rs12468024 chr2:99495980 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.36 -8.36 -0.31 3.82e-16 Bipolar disorder; BRCA trans rs3960554 0.808 rs78587454 chr7:75688672 G/A cg19862616 chr7:65841803 NCRNA00174 0.6 11.98 0.43 5.53e-30 Eotaxin levels; BRCA cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.54 0.55 1.95e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs78707713 0.841 rs76628955 chr10:71208625 C/T cg12610070 chr10:71211762 TSPAN15 -0.32 -8.19 -0.31 1.45e-15 Venous thromboembolism; BRCA cis rs11098499 1.000 rs7659194 chr4:120207147 T/G cg09307838 chr4:120376055 NA 0.64 13.17 0.46 3.09e-35 Corneal astigmatism; BRCA cis rs1476670 0.710 rs4660763 chr1:44503576 T/C cg09470012 chr1:44509516 NA 0.42 9.46 0.35 5.76e-20 Eotaxin levels; BRCA cis rs1348850 0.567 rs7605609 chr2:178534942 C/G cg22681709 chr2:178499509 PDE11A -0.39 -8.46 -0.32 1.82e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs17376456 0.877 rs9314095 chr5:93425495 T/C cg21475434 chr5:93447410 FAM172A 0.69 8.94 0.33 4.08e-18 Diabetic retinopathy; BRCA cis rs7301826 1.000 rs10744482 chr12:131298195 C/T cg11011512 chr12:131303247 STX2 0.4 9.98 0.37 6.6e-22 Plasma plasminogen activator levels; BRCA cis rs7264396 0.635 rs2064724 chr20:34522520 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.94 -0.51 1.6e-43 Total cholesterol levels; BRCA cis rs9291683 0.546 rs13146686 chr4:10034933 A/G cg11266682 chr4:10021025 SLC2A9 0.43 11.36 0.41 2.19e-27 Bone mineral density; BRCA cis rs875971 0.545 rs75840613 chr7:65841386 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.53 9.97 0.37 7.08e-22 Aortic root size; BRCA cis rs708547 0.599 rs2948348 chr4:57848772 G/A cg25525207 chr4:57843836 C4orf14;POLR2B -0.41 -8.44 -0.32 2.06e-16 Response to bleomycin (chromatid breaks); BRCA cis rs8180040 0.966 rs11130128 chr3:47486632 T/C cg27129171 chr3:47204927 SETD2 -0.68 -15.8 -0.53 9.76e-48 Colorectal cancer; BRCA cis rs7772486 0.754 rs4896841 chr6:146041522 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.58 -0.32 7.4e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2806561 0.828 rs944509 chr1:23542242 C/T cg19743168 chr1:23544995 NA -0.47 -11.69 -0.42 9.82e-29 Height; BRCA cis rs4819052 0.851 rs2838833 chr21:46665160 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.05 0.49 2.82e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35110281 0.774 rs1003280 chr21:44997322 A/G cg21573476 chr21:45109991 RRP1B -0.34 -8.98 -0.33 3e-18 Mean corpuscular volume; BRCA cis rs3733585 0.699 rs6449159 chr4:9960498 G/A cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7481584 0.581 rs420127 chr11:3077990 C/T cg08508325 chr11:3079039 CARS 0.29 8.67 0.32 3.67e-17 Calcium levels; BRCA cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg20891558 chr2:74357851 NA 0.6 12.0 0.43 4.43e-30 Gestational age at birth (maternal effect); BRCA cis rs6089829 0.962 rs6089826 chr20:61668595 G/A cg08564027 chr20:61660810 NA 0.84 22.49 0.66 6.16e-83 Prostate cancer (SNP x SNP interaction); BRCA cis rs25645 0.502 rs8065126 chr17:38099035 C/T cg17344932 chr17:38183730 MED24;SNORD124 0.46 10.1 0.37 2.29e-22 Myeloid white cell count; BRCA cis rs4481887 0.893 rs6702113 chr1:248486151 T/C cg13385794 chr1:248469461 NA 0.27 7.89 0.3 1.32e-14 Common traits (Other); BRCA trans rs6582630 0.555 rs11182148 chr12:38464883 A/C cg06521331 chr12:34319734 NA -0.44 -8.51 -0.32 1.24e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg04450456 chr4:17643702 FAM184B -0.34 -9.65 -0.36 1.18e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs1005277 0.579 rs2474595 chr10:38426782 C/G cg23533926 chr12:111358616 MYL2 0.42 8.79 0.33 1.38e-17 Extrinsic epigenetic age acceleration; BRCA cis rs62064224 0.714 rs4794917 chr17:30636146 C/G cg18200150 chr17:30822561 MYO1D 0.35 8.91 0.33 5.17e-18 Schizophrenia; BRCA cis rs1005277 0.522 rs7072977 chr10:37940440 C/A cg00409905 chr10:38381863 ZNF37A -0.48 -9.98 -0.37 6.6e-22 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs1527517 chr4:98931907 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2806561 0.929 rs10917357 chr1:23535161 C/T cg19743168 chr1:23544995 NA 0.46 11.24 0.41 7.16e-27 Height; BRCA cis rs3858526 0.959 rs11039699 chr11:5951091 G/A cg05234568 chr11:5960015 NA -0.51 -9.93 -0.37 1.04e-21 DNA methylation (variation); BRCA cis rs11098499 0.909 rs28581362 chr4:120283548 T/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs12200560 0.505 rs211172 chr6:97070691 C/A cg06623918 chr6:96969491 KIAA0776 0.52 12.25 0.44 3.94e-31 Coronary heart disease; BRCA cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg16145915 chr7:1198662 ZFAND2A 0.41 9.22 0.34 4.41e-19 Longevity;Endometriosis; BRCA trans rs7618501 0.602 rs6780731 chr3:50017478 A/G cg21665057 chr3:196295764 WDR53;FBXO45 0.33 9.04 0.34 1.86e-18 Intelligence (multi-trait analysis); BRCA cis rs74417235 0.684 rs13179358 chr5:154059746 C/A cg08754654 chr5:154026448 NA 0.43 9.87 0.36 1.72e-21 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs10754283 0.967 rs1317864 chr1:90105448 A/G cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.2e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs703842 1.000 rs10783847 chr12:58196447 G/A cg00677455 chr12:58241039 CTDSP2 0.62 15.19 0.52 9.72e-45 Multiple sclerosis; BRCA cis rs7818345 1.000 rs12675717 chr8:19293177 G/A cg11303988 chr8:19266685 CSGALNACT1 0.31 8.05 0.3 4.19e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs34779708 0.931 rs2001893 chr10:35300623 G/A cg03585969 chr10:35415529 CREM 0.45 9.47 0.35 5.36e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6840258 1.000 rs17012234 chr4:87911691 A/C cg08197287 chr4:87952173 AFF1 0.42 8.3 0.31 6.03e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs10256972 0.521 rs7457418 chr7:1110255 C/T cg04025307 chr7:1156635 C7orf50 0.43 10.46 0.38 9.9899999999999993e-24 Longevity;Endometriosis; BRCA cis rs9649465 1.000 rs55633050 chr7:123388474 A/G cg04330084 chr7:123175371 IQUB -0.3 -8.27 -0.31 7.83e-16 Migraine; BRCA cis rs9325144 0.555 rs10748433 chr12:38696352 C/G cg26384229 chr12:38710491 ALG10B 0.55 14.03 0.49 3.44e-39 Morning vs. evening chronotype; BRCA cis rs2197308 0.740 rs11182967 chr12:37935140 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.04 0.37 3.97e-22 Morning vs. evening chronotype; BRCA cis rs6920965 0.509 rs654213 chr6:126149127 C/T cg05901451 chr6:126070800 HEY2 0.36 8.75 0.33 1.95e-17 High light scatter reticulocyte count; BRCA cis rs7617773 0.780 rs13081169 chr3:48356797 G/A cg11946769 chr3:48343235 NME6 0.69 14.01 0.48 4.54e-39 Coronary artery disease; BRCA cis rs1983170 1.000 rs597288 chr1:91999296 C/T cg25838465 chr1:92012736 NA 0.48 9.86 0.36 1.9e-21 Eosinophil percentage of white cells; BRCA cis rs7552404 1.000 rs12091720 chr1:76186949 G/A cg03433033 chr1:76189801 ACADM 0.76 17.13 0.56 2.14e-54 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7827545 1.000 rs7832857 chr8:135565477 A/G cg17885191 chr8:135476712 NA 0.47 9.19 0.34 5.3e-19 Hypertension (SNP x SNP interaction); BRCA cis rs936229 0.813 rs2168519 chr15:75080872 T/C cg14664628 chr15:75095509 CSK -0.91 -26.0 -0.72 3.38e-102 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7772486 0.597 rs2485631 chr6:146190077 G/C cg13319975 chr6:146136371 FBXO30 -0.62 -14.53 -0.5 1.61e-41 Lobe attachment (rater-scored or self-reported); BRCA cis rs344364 0.511 rs12599337 chr16:1946751 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 0.5 8.94 0.33 4.19e-18 Glomerular filtration rate in chronic kidney disease; BRCA cis rs7267979 1.000 rs6115168 chr20:25372891 C/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs801193 1.000 rs2003301 chr7:66147656 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.09 -0.3 3.1e-15 Aortic root size; BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg16606324 chr3:10149918 C3orf24 0.58 10.28 0.38 4.75e-23 Alzheimer's disease; BRCA trans rs11098499 0.954 rs2892848 chr4:120381341 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.83 0.45 1.04e-33 Corneal astigmatism; BRCA cis rs1707322 0.752 rs28623463 chr1:46170758 A/C cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6088590 0.901 rs6087631 chr20:33403509 T/C cg06115741 chr20:33292138 TP53INP2 0.5 11.38 0.41 1.84e-27 Coronary artery disease; BRCA cis rs6546550 1.000 rs6546550 chr2:70038232 C/G cg02498382 chr2:70120550 SNRNP27 -0.49 -10.2 -0.37 9.51e-23 Prevalent atrial fibrillation; BRCA cis rs796364 0.616 rs2689762 chr2:200687204 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.34 0.31 4.51e-16 Schizophrenia; BRCA cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA trans rs11098499 0.954 rs13107475 chr4:120393011 A/T cg25214090 chr10:38739885 LOC399744 0.54 12.64 0.45 7.8e-33 Corneal astigmatism; BRCA cis rs12497850 0.931 rs9835307 chr3:48857805 T/C cg07636037 chr3:49044803 WDR6 0.97 28.33 0.75 5.26e-115 Parkinson's disease; BRCA cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg11189052 chr15:85197271 WDR73 0.44 9.04 0.34 1.91e-18 Schizophrenia; BRCA cis rs7523050 0.730 rs12734623 chr1:109442654 A/G cg08274380 chr1:109419600 GPSM2 1.19 16.9 0.56 3.19e-53 Fat distribution (HIV); BRCA cis rs7493 1.000 rs2040993 chr7:95047300 T/A cg21856205 chr7:94953877 PON1 -0.37 -7.89 -0.3 1.36e-14 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs1113500 0.966 rs11185249 chr1:108611646 C/A cg06207961 chr1:108661230 NA 0.44 10.54 0.38 4.57e-24 Growth-regulated protein alpha levels; BRCA cis rs2463822 0.614 rs117699706 chr11:62161659 T/C cg06239285 chr11:62104954 ASRGL1 -0.67 -9.12 -0.34 9.83e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg09525523 chr12:16064153 DERA 0.32 8.03 0.3 4.82e-15 Mosquito bite size; BRCA cis rs6951245 1.000 rs78896566 chr7:1080182 C/G cg23708337 chr7:1209742 NA 0.63 8.86 0.33 8.16e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4742903 0.527 rs10991114 chr9:106885616 A/G cg14250997 chr9:106856677 SMC2 0.29 8.57 0.32 7.68e-17 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.02e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7300001 0.667 rs7302198 chr12:110506280 T/C cg12870014 chr12:110450643 ANKRD13A 0.59 8.05 0.3 3.99e-15 Headache; BRCA cis rs74181299 0.819 rs2723087 chr2:65298282 T/A cg05010058 chr2:65284262 CEP68 0.3 8.27 0.31 7.74e-16 Pulse pressure; BRCA cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg02659138 chr7:134003124 SLC35B4 0.32 9.8 0.36 3.24e-21 Mean platelet volume; BRCA cis rs1829883 0.583 rs115209822 chr5:98915203 G/A cg08333243 chr5:99726346 NA 0.35 8.01 0.3 5.39e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs3806843 0.735 rs801168 chr5:140080298 A/G cg11822812 chr5:140052017 DND1 -0.29 -8.05 -0.3 4.14e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg18016565 chr1:150552671 MCL1 -0.37 -8.56 -0.32 8.12e-17 Tonsillectomy; BRCA cis rs1707322 0.721 rs12037803 chr1:46156492 A/G cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10503871 0.967 rs4403367 chr8:30439724 A/G cg26383811 chr8:30366931 RBPMS 0.33 8.91 0.33 5.24e-18 Metabolite levels (X-11787); BRCA cis rs7100689 0.622 rs2994389 chr10:82062257 C/G cg01528321 chr10:82214614 TSPAN14 0.79 16.67 0.55 4.64e-52 Post bronchodilator FEV1; BRCA cis rs1707322 0.717 rs3014237 chr1:46090252 A/G cg03146154 chr1:46216737 IPP -0.51 -11.13 -0.4 2.06e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11764590 0.715 rs55770986 chr7:2087823 T/C cg02743256 chr7:2109353 MAD1L1 -0.45 -8.0 -0.3 5.82e-15 Neuroticism; BRCA cis rs9814567 0.964 rs9815983 chr3:134222507 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.0 -0.34 2.48e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6910061 0.830 rs9468408 chr6:11093745 C/T cg27233058 chr6:11094804 LOC221710 0.5 8.43 0.32 2.33e-16 Diabetic kidney disease; BRCA cis rs7582180 0.629 rs2309798 chr2:100956949 G/A cg14675211 chr2:100938903 LONRF2 0.45 10.36 0.38 2.46e-23 Intelligence (multi-trait analysis); BRCA cis rs910316 0.737 rs175077 chr14:75506875 G/A cg11812906 chr14:75593930 NEK9 -0.61 -13.69 -0.48 1.38e-37 Height; BRCA cis rs2882667 0.858 rs4643949 chr5:138372345 C/T cg04439458 chr5:138467593 SIL1 -0.32 -8.8 -0.33 1.3e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg24549020 chr5:56110836 MAP3K1 0.67 13.67 0.48 1.63e-37 Initial pursuit acceleration; BRCA cis rs1949733 1.000 rs2140337 chr4:8502112 A/G cg13073564 chr4:8508604 NA -0.43 -11.9 -0.43 1.21e-29 Response to antineoplastic agents; BRCA cis rs9549367 0.789 rs71446679 chr13:113894821 C/T cg18105134 chr13:113819100 PROZ -0.63 -14.22 -0.49 4.32e-40 Platelet distribution width; BRCA cis rs7552404 0.727 rs1146653 chr1:76280438 A/G cg10523679 chr1:76189770 ACADM 0.58 11.0 0.4 6.66e-26 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17270561 0.609 rs4145217 chr6:25743997 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs17270561 0.609 rs4711096 chr6:25727054 A/G cg16482183 chr6:26056742 HIST1H1C 0.47 8.98 0.33 2.89e-18 Iron status biomarkers; BRCA cis rs7647973 0.710 rs6446285 chr3:49626306 G/A cg07636037 chr3:49044803 WDR6 0.58 8.27 0.31 7.6e-16 Menarche (age at onset); BRCA cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg16405210 chr4:1374714 KIAA1530 0.85 17.48 0.57 3.11e-56 Longevity; BRCA cis rs10504229 1.000 rs67388517 chr8:58176617 C/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs7279011 chr21:46655995 G/A cg06618935 chr21:46677482 NA -0.36 -8.11 -0.31 2.68e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2153535 0.580 rs1414349 chr6:8472290 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs425277 0.583 rs4648807 chr1:2040898 A/G cg12639453 chr1:2035780 PRKCZ -0.28 -8.04 -0.3 4.31e-15 Height; BRCA cis rs4727027 0.769 rs10952797 chr7:148816722 A/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.5 10.58 0.39 3.2e-24 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6750047 0.585 rs168054 chr2:38260282 C/G cg07380506 chr2:38303506 CYP1B1 -0.42 -9.62 -0.36 1.48e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs2282802 0.685 rs62385161 chr5:139635747 T/C cg26211634 chr5:139558579 C5orf32 0.35 8.22 0.31 1.17e-15 Intelligence (multi-trait analysis); BRCA cis rs875971 1.000 rs3981131 chr7:65951677 A/G cg18876405 chr7:65276391 NA 0.52 12.56 0.44 1.77e-32 Aortic root size; BRCA cis rs2730245 1.000 rs2730241 chr7:158723014 T/C cg24397884 chr7:158709396 WDR60 -0.95 -22.78 -0.67 1.46e-84 Height; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg25036284 chr2:26402008 FAM59B 0.96 16.09 0.54 3.8e-49 Gut microbiome composition (summer); BRCA cis rs782590 0.764 rs2586970 chr2:55829967 A/G cg18811423 chr2:55921094 PNPT1 0.68 20.87 0.64 3.62e-74 Metabolic syndrome; BRCA cis rs698833 0.509 rs4952709 chr2:44519142 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.55 0.32 9.05e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs9487051 0.698 rs4301336 chr6:109650140 A/T cg01475377 chr6:109611718 NA 0.46 10.0 0.37 5.48e-22 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg08280861 chr8:58055591 NA 0.52 8.47 0.32 1.71e-16 Developmental language disorder (linguistic errors); BRCA cis rs2282802 0.660 rs2436390 chr5:139586501 G/A cg26211634 chr5:139558579 C5orf32 -0.34 -8.14 -0.31 2.13e-15 Intelligence (multi-trait analysis); BRCA cis rs9807989 0.507 rs3213732 chr2:102998279 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.41 0.32 2.59e-16 Asthma; BRCA cis rs6424115 0.965 rs2502986 chr1:24135292 G/T cg10978503 chr1:24200527 CNR2 0.44 11.68 0.42 1.04e-28 Immature fraction of reticulocytes; BRCA cis rs9467773 0.587 rs10946813 chr6:26345141 A/G cg09904177 chr6:26538194 HMGN4 0.31 8.39 0.31 3.21e-16 Intelligence (multi-trait analysis); BRCA cis rs11711311 1.000 rs9830978 chr3:113455940 A/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.44 -9.73 -0.36 5.71e-21 IgG glycosylation; BRCA trans rs2204008 0.837 rs55962152 chr12:38234281 G/A cg06521331 chr12:34319734 NA -0.49 -9.07 -0.34 1.51e-18 Bladder cancer; BRCA cis rs7772486 0.875 rs2814866 chr6:146339414 C/A cg23711669 chr6:146136114 FBXO30 0.64 14.59 0.5 8.29e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs1218582 0.741 rs883718 chr1:154846274 C/T cg24250549 chr1:154909240 PMVK 0.67 17.32 0.57 2.23e-55 Prostate cancer; BRCA trans rs7200543 1.000 rs55727637 chr16:15145252 C/T cg24683922 chr1:11983373 KIAA2013 -0.36 -8.35 -0.31 4.25e-16 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs9814567 1.000 rs9863786 chr3:134247203 C/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.9 -0.3 1.2e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35110281 0.782 rs2329442 chr21:45041790 T/C cg01579765 chr21:45077557 HSF2BP -0.43 -11.45 -0.41 1e-27 Mean corpuscular volume; BRCA cis rs1059312 0.966 rs12368452 chr12:129277164 C/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.27 8.86 0.33 7.79e-18 Systemic lupus erythematosus; BRCA cis rs2032447 0.966 rs3752416 chr6:26045929 T/C cg03264133 chr6:25882463 NA -0.43 -9.38 -0.35 1.08e-19 Intelligence (multi-trait analysis); BRCA cis rs17685 0.753 rs1859791 chr7:75786043 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.54 -0.32 9.97e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1891275 0.508 rs2096079 chr10:93496667 C/G cg07889827 chr10:93443413 NA -0.41 -11.09 -0.4 2.95e-26 Intelligence (multi-trait analysis); BRCA cis rs798554 0.759 rs1182189 chr7:2869522 G/A cg23285459 chr7:2802560 GNA12 -0.35 -8.48 -0.32 1.57e-16 Height; BRCA cis rs780096 0.587 rs6743819 chr2:27567407 G/T cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.47 -0.32 1.71e-16 Total body bone mineral density; BRCA cis rs1862618 0.671 rs2034244 chr5:56242774 T/C cg12311346 chr5:56204834 C5orf35 0.56 11.79 0.42 3.62e-29 Initial pursuit acceleration; BRCA cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg08885076 chr2:99613938 TSGA10 -0.6 -13.41 -0.47 2.63e-36 Chronic sinus infection; BRCA cis rs1862618 0.853 rs832554 chr5:56115036 A/G cg24549020 chr5:56110836 MAP3K1 0.61 12.69 0.45 4.51e-33 Initial pursuit acceleration; BRCA cis rs8180040 0.966 rs12486969 chr3:47429003 G/C cg16586182 chr3:47516702 SCAP 0.65 15.06 0.51 4.49e-44 Colorectal cancer; BRCA trans rs2204008 0.837 rs12366727 chr12:38365748 A/C cg06521331 chr12:34319734 NA -0.52 -9.28 -0.34 2.67e-19 Bladder cancer; BRCA cis rs644148 0.693 rs2686772 chr19:44999729 T/C cg15540054 chr19:45004280 ZNF180 -0.51 -10.07 -0.37 3.03e-22 Personality dimensions; BRCA cis rs11608355 0.545 rs11612500 chr12:109897136 T/C cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs2243480 1.000 rs35283677 chr7:65359233 C/T cg18252515 chr7:66147081 NA -0.87 -12.08 -0.43 2.13e-30 Diabetic kidney disease; BRCA cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.42 0.32 2.39e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs561341 1.000 rs530209 chr17:30315287 A/G cg12193833 chr17:30244370 NA -0.55 -8.77 -0.33 1.62e-17 Hip circumference adjusted for BMI; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg27170947 chr2:26402098 FAM59B 0.97 17.16 0.56 1.38e-54 Gut microbiome composition (summer); BRCA trans rs4718428 0.705 rs4717331 chr7:66378886 C/T cg18876405 chr7:65276391 NA 0.43 8.48 0.32 1.53e-16 Corneal structure; BRCA cis rs7927771 1.000 rs2290850 chr11:47807774 T/C cg18512352 chr11:47633146 NA -0.34 -8.3 -0.31 6.07e-16 Subjective well-being; BRCA cis rs1552244 0.882 rs56224841 chr3:10044014 A/C cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.6 -12.56 -0.44 1.73e-32 Personality dimensions; BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg03188948 chr7:1209495 NA 0.85 11.6 0.42 2.26e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7399018 0.739 rs6580811 chr12:51612501 T/C cg20712883 chr12:51590929 POU6F1 0.4 7.96 0.3 7.84e-15 Cisplatin-induced ototoxicity; BRCA cis rs2075371 0.611 rs34573600 chr7:134018937 C/T cg11752832 chr7:134001865 SLC35B4 0.43 9.51 0.35 3.84e-20 Mean platelet volume; BRCA cis rs9815354 0.627 rs115971784 chr3:42016146 T/C cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14442939 chr10:27389572 ANKRD26 0.7 11.01 0.4 6.19e-26 Breast cancer; BRCA cis rs6121246 0.909 rs6060929 chr20:30345914 C/T cg21427119 chr20:30132790 HM13 -0.41 -8.75 -0.33 1.93e-17 Mean corpuscular hemoglobin; BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13732083 chr21:47605072 C21orf56 0.37 7.98 0.3 7e-15 Testicular germ cell tumor; BRCA cis rs57221529 0.709 rs111352378 chr5:577079 G/A cg09021430 chr5:549028 NA -0.68 -14.24 -0.49 3.68e-40 Lung disease severity in cystic fibrosis; BRCA cis rs10949834 0.504 rs13238778 chr7:73567709 G/A cg07137043 chr7:73588983 EIF4H -0.66 -10.48 -0.38 8.24e-24 Verbal memory performance (residualized delayed recall change); BRCA cis rs801193 1.000 rs1553610 chr7:66197233 T/C cg11764359 chr7:65958608 NA 0.68 15.21 0.52 8.16e-45 Aortic root size; BRCA cis rs2153535 0.542 rs9393012 chr6:8439809 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.49 0.38 7.36e-24 Motion sickness; BRCA trans rs8073060 0.586 rs225294 chr17:33925762 G/A cg19694781 chr19:47549865 TMEM160 -1.01 -21.06 -0.64 3.73e-75 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs754466 0.606 rs56402185 chr10:79585848 G/A cg17075019 chr10:79541650 NA -0.81 -21.33 -0.64 1.23e-76 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg05025164 chr4:1340916 KIAA1530 0.37 8.34 0.31 4.58e-16 Longevity; BRCA cis rs908922 0.676 rs1123567 chr1:152516023 G/A cg20991723 chr1:152506922 NA 0.39 9.01 0.34 2.44e-18 Hair morphology; BRCA cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg10802521 chr3:52805072 NEK4 -0.33 -8.48 -0.32 1.61e-16 Bipolar disorder; BRCA cis rs6860806 0.531 rs272888 chr5:131665423 T/C cg12564285 chr5:131593104 PDLIM4 0.34 7.87 0.3 1.52e-14 Breast cancer; BRCA cis rs400736 0.671 rs2131630 chr1:7990367 G/A cg25007680 chr1:8021821 PARK7 -0.42 -10.44 -0.38 1.11e-23 Response to antidepressants and depression; BRCA cis rs514406 0.755 rs11206015 chr1:53242187 T/C cg27535305 chr1:53392650 SCP2 0.33 8.11 0.31 2.57e-15 Monocyte count; BRCA cis rs2153535 0.580 rs9505446 chr6:8448691 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs10504073 0.647 rs56057508 chr8:49982793 G/T cg00325661 chr8:49890786 NA 0.42 12.08 0.43 2.18e-30 Blood metabolite ratios; BRCA cis rs10267417 0.603 rs6960607 chr7:19869407 A/G cg05791153 chr7:19748676 TWISTNB 0.46 8.96 0.33 3.59e-18 Night sleep phenotypes; BRCA cis rs6952809 0.532 rs10227362 chr7:2456799 A/G cg05083358 chr7:2394359 EIF3B -0.49 -7.89 -0.3 1.29e-14 Multiple sclerosis; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10129255 0.500 rs10131875 chr14:107201036 T/C cg07958169 chr14:107095056 NA -0.39 -8.45 -0.32 1.89e-16 Kawasaki disease; BRCA cis rs4805272 0.512 rs7260055 chr19:29341599 G/A cg12756686 chr19:29218302 NA 0.47 8.32 0.31 5.17e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs1005277 0.540 rs116205409 chr10:38478970 G/A cg25427524 chr10:38739819 LOC399744 -0.73 -18.04 -0.58 4.15e-59 Extrinsic epigenetic age acceleration; BRCA cis rs6835098 0.816 rs13111572 chr4:174159788 G/A cg08422745 chr4:174089978 GALNT7 0.79 14.78 0.5 9.57e-43 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg04450456 chr4:17643702 FAM184B 0.37 10.91 0.4 1.54e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs780096 0.526 rs1260342 chr2:27663416 G/T cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs7666738 0.753 rs10004827 chr4:99037953 A/C cg05340658 chr4:99064831 C4orf37 0.69 17.44 0.57 5.19e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs4332037 0.538 rs6951956 chr7:1934131 C/T cg23422044 chr7:1970798 MAD1L1 -0.54 -11.91 -0.43 1.11e-29 Bipolar disorder; BRCA cis rs7582180 0.563 rs4851304 chr2:100963871 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.59 0.42 2.46e-28 Intelligence (multi-trait analysis); BRCA cis rs12586317 0.525 rs10144430 chr14:35433682 T/A cg16230307 chr14:35515116 FAM177A1 0.62 13.76 0.48 6.46e-38 Psoriasis; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg18765753 chr7:1198926 ZFAND2A -0.48 -11.7 -0.42 8.77e-29 Longevity;Endometriosis; BRCA trans rs561341 1.000 rs561341 chr17:30316385 T/G cg27661571 chr11:113659931 NA -0.71 -10.93 -0.4 1.31e-25 Hip circumference adjusted for BMI; BRCA cis rs11229555 0.645 rs35279927 chr11:58212129 G/T cg15696309 chr11:58395628 NA -0.45 -9.64 -0.36 1.27e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6866344 0.570 rs56236920 chr5:178144617 C/T cg10224037 chr5:178157518 ZNF354A 0.79 17.62 0.57 6.43e-57 Neutrophil percentage of white cells; BRCA cis rs2153535 0.580 rs3938660 chr6:8443335 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs2730245 0.563 rs2709857 chr7:158685257 T/C cg14689365 chr7:158441557 NCAPG2 0.41 8.71 0.33 2.53e-17 Height; BRCA cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg24531977 chr5:56204891 C5orf35 -0.55 -11.38 -0.41 1.87e-27 Coronary artery disease; BRCA cis rs561341 0.769 rs9899093 chr17:30191954 C/G cg23018236 chr17:30244563 NA -0.63 -9.46 -0.35 5.68e-20 Hip circumference adjusted for BMI; BRCA trans rs6951245 0.872 rs113119264 chr7:1080564 G/A cg13565492 chr6:43139072 SRF -0.79 -11.12 -0.4 2.25e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg04944784 chr2:26401820 FAM59B -0.66 -11.2 -0.41 1.05e-26 Gut microbiome composition (summer); BRCA cis rs7666738 0.791 rs1896155 chr4:99020948 C/A cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs3845702 0.736 rs1904850 chr2:180852767 A/G cg01881094 chr2:180872142 CWC22 -1.02 -18.38 -0.59 6.81e-61 Schizophrenia; BRCA cis rs6088590 0.965 rs6120727 chr20:33374102 T/C cg06115741 chr20:33292138 TP53INP2 0.5 11.12 0.4 2.28e-26 Coronary artery disease; BRCA cis rs2153535 0.580 rs1832101 chr6:8460177 A/G cg21535247 chr6:8435926 SLC35B3 0.4 8.91 0.33 5.31e-18 Motion sickness; BRCA cis rs2859741 1.000 rs4653239 chr1:37509872 C/G cg09363841 chr1:37513479 NA 0.65 16.06 0.54 5.02e-49 Forced expiratory volume in 1 second (environmental tobacco smoke interaction); BRCA cis rs9814567 0.964 rs6805388 chr3:134173534 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.55 -16.73 -0.55 2.31e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1348850 0.872 rs2084233 chr2:178331206 G/A cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.85 0.36 2.06e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs11711311 1.000 rs9288983 chr3:113488699 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.39 10.26 0.38 5.81e-23 IgG glycosylation; BRCA cis rs739401 0.611 rs12284275 chr11:3024384 T/C cg05729581 chr11:3078854 CARS -0.36 -8.82 -0.33 1.12e-17 Longevity; BRCA trans rs11039798 1.000 rs12225599 chr11:48755868 T/C cg15704280 chr7:45808275 SEPT13 0.59 8.84 0.33 9.53e-18 Axial length; BRCA cis rs6083 0.536 rs4528512 chr15:58852226 A/T cg05156742 chr15:59063176 FAM63B 0.4 8.67 0.32 3.5e-17 Schizophrenia; BRCA cis rs11971779 0.941 rs1127424 chr7:139107660 A/G cg07862535 chr7:139043722 LUC7L2 0.52 12.86 0.45 7.86e-34 Diisocyanate-induced asthma; BRCA cis rs3772130 1.000 rs13083794 chr3:121464928 T/G cg01951420 chr3:121553821 IQCB1;EAF2 0.55 9.61 0.36 1.57e-20 Cognitive performance; BRCA trans rs1945213 0.659 rs2086558 chr11:55844453 T/G cg03929089 chr4:120376271 NA 0.6 10.38 0.38 2.02e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs8180040 0.932 rs62248599 chr3:47516728 G/A cg27129171 chr3:47204927 SETD2 -0.68 -16.18 -0.54 1.29e-49 Colorectal cancer; BRCA trans rs561341 0.654 rs6505265 chr17:30172580 C/T cg20587970 chr11:113659929 NA 0.89 12.97 0.46 2.67e-34 Hip circumference adjusted for BMI; BRCA cis rs9811920 0.638 rs1688782 chr3:99630527 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.64 -15.15 -0.51 1.59e-44 Axial length; BRCA cis rs4481887 0.927 rs4453081 chr1:248475691 C/G cg00666640 chr1:248458726 OR2T12 0.3 8.44 0.32 2.09e-16 Common traits (Other); BRCA cis rs6912958 0.712 rs2754262 chr6:88405585 A/G cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.32 -0.31 5.19e-16 Monocyte percentage of white cells; BRCA cis rs7618501 0.571 rs2240329 chr3:50107512 G/A cg24308560 chr3:49941425 MST1R 0.39 8.48 0.32 1.55e-16 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.935 rs7621551 chr3:10114205 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.86 0.6 2.15e-63 Alzheimer's disease; BRCA cis rs3772130 0.962 rs1920320 chr3:121547527 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.64 0.39 1.94e-24 Cognitive performance; BRCA trans rs1005277 0.540 rs1814077 chr10:37992018 G/C cg17830980 chr10:43048298 ZNF37B -0.42 -9.86 -0.36 1.86e-21 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.580 rs2184585 chr6:8474168 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs60843830 1.000 rs17713729 chr2:249092 A/C cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.36 0.49 9.69e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs17401966 1.000 rs35837142 chr1:10322358 C/G cg15208524 chr1:10270712 KIF1B 0.4 8.47 0.32 1.72e-16 Hepatocellular carcinoma; BRCA cis rs514406 0.929 rs12410420 chr1:53323754 T/C cg08859206 chr1:53392774 SCP2 -0.52 -11.34 -0.41 2.72e-27 Monocyte count; BRCA cis rs6893300 0.857 rs62406181 chr5:179171803 G/A cg14593053 chr5:179126677 CANX -0.35 -7.95 -0.3 8.56e-15 Resting heart rate; BRCA cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11890956 chr21:40555474 PSMG1 -0.84 -21.45 -0.65 2.87e-77 Cognitive function; BRCA cis rs9815354 0.812 rs73081383 chr3:41920614 A/G cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7103648 0.669 rs7927445 chr11:47780754 G/T cg20307385 chr11:47447363 PSMC3 0.74 16.8 0.55 9.88e-53 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs7666738 0.861 rs28829607 chr4:98964325 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7044106 0.664 rs7861679 chr9:123375589 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.66 -14.12 -0.49 1.31e-39 Hip circumference adjusted for BMI; BRCA cis rs2304069 0.644 rs216131 chr5:149431223 C/T cg12661370 chr5:149340060 SLC26A2 0.54 8.12 0.31 2.4e-15 HIV-1 control; BRCA cis rs1003719 0.762 rs4399800 chr21:38489478 G/T cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.14 0.49 1.04e-39 Eye color traits; BRCA cis rs6089829 0.962 rs6062780 chr20:61666648 T/C cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs651907 0.737 rs9844218 chr3:101584983 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.38 -8.77 -0.33 1.67e-17 Colorectal cancer; BRCA cis rs9462027 0.628 rs66506671 chr6:34777149 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.89 -0.3 1.33e-14 Systemic lupus erythematosus; BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg13047869 chr3:10149882 C3orf24 0.5 9.48 0.35 4.92e-20 Alzheimer's disease; BRCA cis rs6763687 0.823 rs12632949 chr3:171802458 C/T cg16233210 chr3:171778391 FNDC3B 0.41 9.67 0.36 9.65e-21 Red cell distribution width; BRCA trans rs61931739 0.500 rs7955247 chr12:34126580 G/A cg13010199 chr12:38710504 ALG10B 0.48 9.26 0.34 3.1e-19 Morning vs. evening chronotype; BRCA cis rs1153858 0.945 rs1974981 chr15:45729123 C/T cg14582100 chr15:45693742 SPATA5L1 -0.35 -11.16 -0.4 1.5e-26 Homoarginine levels; BRCA cis rs858239 0.932 rs1728320 chr7:23319789 T/G cg23682824 chr7:23144976 KLHL7 0.33 8.45 0.32 1.93e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs35110281 0.777 rs7276215 chr21:44990697 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -10.79 -0.39 4.85e-25 Mean corpuscular volume; BRCA cis rs2688608 0.592 rs7908825 chr10:75554541 C/G cg23231163 chr10:75533350 FUT11 0.34 8.98 0.33 2.9e-18 Inflammatory bowel disease; BRCA cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg13319975 chr6:146136371 FBXO30 -0.35 -8.25 -0.31 9.4e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9790314 0.812 rs2004862 chr3:161135638 C/T cg04691961 chr3:161091175 C3orf57 -0.49 -11.86 -0.42 1.91e-29 Morning vs. evening chronotype; BRCA cis rs1941023 0.584 rs4938941 chr11:60173360 C/T cg08716584 chr11:60157161 MS4A7 0.42 9.66 0.36 1.05e-20 Congenital heart disease (maternal effect); BRCA cis rs2050392 0.624 rs303450 chr10:30725337 C/A cg18806716 chr10:30721971 MAP3K8 -0.61 -14.19 -0.49 6.04e-40 Inflammatory bowel disease; BRCA cis rs1580019 0.921 rs1580023 chr7:32497881 G/A cg06627557 chr7:32535165 LSM5;AVL9 0.74 16.17 0.54 1.52e-49 Cognitive ability; BRCA cis rs10504229 0.683 rs56208052 chr8:58130207 A/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6912958 0.712 rs2814712 chr6:88396322 A/C cg08069147 chr6:88032118 GJB7;C6orf162 0.42 8.31 0.31 5.77e-16 Monocyte percentage of white cells; BRCA cis rs870825 0.655 rs35764203 chr4:185639078 C/A cg04058563 chr4:185651563 MLF1IP 0.77 17.27 0.56 3.85e-55 Blood protein levels; BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.0 -20.0 -0.62 1.69e-69 Gut microbiome composition (summer); BRCA cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg11812906 chr14:75593930 NEK9 -0.54 -11.73 -0.42 6.38e-29 Height; BRCA cis rs9462027 0.628 rs9462009 chr6:34716330 G/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.0 -0.3 5.67e-15 Systemic lupus erythematosus; BRCA cis rs72781680 0.898 rs72786298 chr2:24083011 C/T cg08917208 chr2:24149416 ATAD2B 1.08 15.26 0.52 4.69e-45 Lymphocyte counts; BRCA cis rs13191362 1.000 rs7769686 chr6:163199467 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.61 9.75 0.36 5.14e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.53 0.5 1.53e-41 Motion sickness; BRCA cis rs7147624 1.000 rs2898816 chr14:66008160 T/C cg03016385 chr14:66212404 NA -0.59 -8.59 -0.32 6.75e-17 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs6952808 0.594 rs3778969 chr7:2139990 A/G cg00106254 chr7:1943704 MAD1L1 0.39 9.54 0.35 2.89e-20 Bipolar disorder and schizophrenia; BRCA cis rs427394 0.802 rs274694 chr5:6734079 A/G cg10857441 chr5:6722123 POLS -0.33 -10.91 -0.4 1.61e-25 Menopause (age at onset); BRCA cis rs3008870 0.585 rs2815382 chr1:67515228 G/A cg02640540 chr1:67518911 SLC35D1 0.41 8.92 0.33 4.69e-18 Lymphocyte percentage of white cells; BRCA cis rs11098499 0.530 rs114866537 chr4:120258608 A/T cg09307838 chr4:120376055 NA 0.59 12.83 0.45 1.11e-33 Corneal astigmatism; BRCA cis rs6951245 0.872 rs76161580 chr7:1100307 G/T cg22907277 chr7:1156413 C7orf50 0.58 8.91 0.33 5.37e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs798554 0.644 rs7783400 chr7:2894434 A/C cg13628971 chr7:2884303 GNA12 -0.53 -11.47 -0.41 7.9e-28 Height; BRCA cis rs7178424 0.764 rs35967150 chr15:62324471 G/A cg00456672 chr15:62358751 C2CD4A -0.39 -8.56 -0.32 8.18e-17 Height; BRCA cis rs4665809 1.000 rs2891490 chr2:26325927 T/C cg22920501 chr2:26401640 FAM59B -0.65 -11.23 -0.41 8.19e-27 Gut microbiome composition (summer); BRCA cis rs7666738 0.753 rs13137152 chr4:98938044 A/T cg05340658 chr4:99064831 C4orf37 0.67 16.74 0.55 1.9e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.616 rs4585652 chr7:1145396 A/G cg04025307 chr7:1156635 C7orf50 0.75 19.49 0.61 9.61e-67 Longevity;Endometriosis; BRCA cis rs887829 0.531 rs4338954 chr2:234593931 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.36 -0.31 3.84e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg06618935 chr21:46677482 NA -0.38 -8.56 -0.32 8.68e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4727027 0.933 rs12532104 chr7:148864233 A/C cg23583168 chr7:148888333 NA -0.86 -20.12 -0.62 4.19e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs59574136 1 rs59574136 chr7:2036460 T/C cg04565464 chr8:145669602 NFKBIL2 0.37 8.85 0.33 8.54e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs2820292 0.804 rs2644120 chr1:201882277 C/G cg11586189 chr1:201857591 SHISA4 0.28 7.9 0.3 1.23e-14 Waist circumference;Body mass index (joint analysis main effects and smoking interaction);Body mass index;BMI in non-smokers;BMI (adjusted for smoking behaviour); BRCA cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg00074818 chr8:8560427 CLDN23 0.39 8.43 0.32 2.34e-16 Obesity-related traits; BRCA cis rs7953249 0.594 rs11065384 chr12:121423285 T/C cg02403541 chr12:121454288 C12orf43 -0.51 -9.68 -0.36 9.26e-21 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs9443645 0.869 rs4706747 chr6:79722639 A/G cg05283184 chr6:79620031 NA -0.43 -11.0 -0.4 6.58e-26 Intelligence (multi-trait analysis); BRCA trans rs4650994 1.000 rs10913568 chr1:178513411 C/T cg05059571 chr16:84539110 KIAA1609 -0.43 -9.67 -0.36 9.66e-21 HDL cholesterol levels;HDL cholesterol; BRCA cis rs78707713 0.841 rs10998780 chr10:71201735 A/T cg12610070 chr10:71211762 TSPAN15 -0.33 -8.42 -0.32 2.4e-16 Venous thromboembolism; BRCA cis rs7580658 0.545 rs12477559 chr2:127951797 C/T cg16751203 chr2:127950803 CYP27C1 0.28 7.92 0.3 1.09e-14 Protein C levels; BRCA cis rs6121246 0.954 rs6060989 chr20:30429763 C/T cg13852791 chr20:30311386 BCL2L1 0.79 15.26 0.52 4.8e-45 Mean corpuscular hemoglobin; BRCA cis rs13217239 0.646 rs10456352 chr6:26990358 A/T cg12292205 chr6:26970375 C6orf41 0.58 12.99 0.46 2.15e-34 Schizophrenia; BRCA cis rs7666738 0.830 rs62321569 chr4:98984250 T/A cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.84 -17.95 -0.58 1.26e-58 Gut microbiome composition (summer); BRCA cis rs910316 0.874 rs61980828 chr14:75630378 G/A cg23033748 chr14:75592666 NEK9 -0.43 -10.19 -0.37 1.07e-22 Height; BRCA trans rs6076960 0.684 rs3852949 chr20:6264758 T/A cg17788362 chr6:86352627 SYNCRIP 0.4 8.07 0.3 3.53e-15 Smooth-surface caries; BRCA cis rs7020830 0.858 rs7856690 chr9:37127545 A/T cg14294708 chr9:37120828 ZCCHC7 1.04 30.31 0.77 9.8e-126 Schizophrenia; BRCA cis rs3008870 0.920 rs1925413 chr1:67417101 T/C cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.33 0.66 4.28e-82 Lymphocyte percentage of white cells; BRCA cis rs13046373 0.507 rs2832959 chr21:31982934 C/T cg27071517 chr21:31768726 KRTAP13-1 0.29 7.88 0.3 1.37e-14 HDL cholesterol; BRCA cis rs4302748 0.908 rs4723482 chr7:36192249 G/A cg24442661 chr7:36192818 EEPD1 0.51 9.18 0.34 5.74e-19 Platelet count; BRCA cis rs2289583 0.642 rs55798479 chr15:75392210 C/T cg14664628 chr15:75095509 CSK 0.4 9.21 0.34 4.79e-19 Systemic lupus erythematosus; BRCA trans rs11764590 0.585 rs11772463 chr7:2078132 A/C cg11693508 chr17:37793320 STARD3 0.52 9.19 0.34 5.41e-19 Neuroticism; BRCA cis rs60843830 1.000 rs59937473 chr2:271797 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.72 15.09 0.51 3.14e-44 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4891159 0.548 rs689902 chr18:74119969 C/T cg24786174 chr18:74118243 ZNF516 -0.84 -25.89 -0.72 1.22e-101 Longevity; BRCA cis rs244731 0.959 rs6556307 chr5:176641434 C/T cg16006841 chr5:176797999 RGS14 0.72 11.12 0.4 2.15e-26 Urate levels in lean individuals; BRCA cis rs1568889 0.838 rs7131053 chr11:28143312 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.51 0.63 3.25e-72 Bipolar disorder; BRCA cis rs10463316 0.894 rs7703283 chr5:150764904 C/T cg03212797 chr5:150827313 SLC36A1 -0.43 -8.4 -0.32 2.96e-16 Metabolite levels (Pyroglutamine); BRCA cis rs992157 0.775 rs1877714 chr2:219134928 A/G cg00012203 chr2:219082015 ARPC2 -0.52 -10.4 -0.38 1.58e-23 Colorectal cancer; BRCA trans rs1459104 0.925 rs12576020 chr11:55221500 G/A cg15704280 chr7:45808275 SEPT13 0.67 8.35 0.31 4.13e-16 Body mass index; BRCA cis rs7394190 0.748 rs1057410 chr10:75574079 G/A cg07699608 chr10:75541558 CHCHD1 0.65 9.76 0.36 4.46e-21 Incident atrial fibrillation; BRCA trans rs75804782 0.521 rs55713398 chr2:239419933 A/G cg01134436 chr17:81009848 B3GNTL1 0.68 8.73 0.33 2.26e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs9986765 0.737 rs10274253 chr7:142810265 G/C cg21852589 chr7:142981689 TMEM139 0.65 10.38 0.38 1.99e-23 Cancer;Dermatomyositis; BRCA cis rs910316 0.737 rs175048 chr14:75479894 A/T cg08847533 chr14:75593920 NEK9 -0.79 -19.07 -0.6 1.52e-64 Height; BRCA cis rs35110281 0.501 rs162381 chr21:44920915 A/G cg01579765 chr21:45077557 HSF2BP 0.33 8.35 0.31 4.28e-16 Mean corpuscular volume; BRCA cis rs9457247 0.602 rs12208359 chr6:167458455 G/A cg07741184 chr6:167504864 NA 0.35 10.15 0.37 1.57e-22 Crohn's disease; BRCA cis rs2370759 1.000 rs79578760 chr10:32611264 C/A cg01819863 chr10:32635814 EPC1 1.16 20.18 0.62 1.86e-70 Sexual dysfunction (female); BRCA cis rs2303759 0.918 rs7251704 chr19:49890873 T/G cg22590775 chr19:49891494 CCDC155 0.49 8.72 0.33 2.44e-17 Multiple sclerosis; BRCA cis rs12618769 0.597 rs3769743 chr2:99063653 C/T cg10123293 chr2:99228465 UNC50 0.4 8.17 0.31 1.71e-15 Bipolar disorder; BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg03709012 chr19:19516395 GATAD2A 0.81 18.95 0.6 7.16e-64 Tonsillectomy; BRCA cis rs67478160 0.643 rs11628332 chr14:104241141 C/T cg26031613 chr14:104095156 KLC1 -0.41 -8.12 -0.31 2.45e-15 Schizophrenia; BRCA cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg11833968 chr6:79620685 NA -0.46 -10.29 -0.38 4.47e-23 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.595 rs116490935 chr8:58117531 A/G cg20607798 chr8:58055168 NA 0.47 8.25 0.31 9.1e-16 Developmental language disorder (linguistic errors); BRCA cis rs11711311 1.000 rs3806641 chr3:113465761 T/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.75 -0.36 5.06e-21 IgG glycosylation; BRCA cis rs6061231 0.793 rs6061512 chr20:60976929 G/A cg22601191 chr20:60968625 CABLES2 0.42 9.95 0.37 9.04e-22 Colorectal cancer; BRCA cis rs4975616 0.714 rs37007 chr5:1352372 G/C cg07493874 chr5:1342172 CLPTM1L -0.46 -12.63 -0.45 8.1e-33 Lung cancer; BRCA trans rs7618501 0.602 rs2240326 chr3:50128386 G/A cg21659725 chr3:3221576 CRBN -0.5 -12.81 -0.45 1.31e-33 Intelligence (multi-trait analysis); BRCA cis rs7818345 0.967 rs4549789 chr8:19284015 C/A cg11303988 chr8:19266685 CSGALNACT1 0.32 8.2 0.31 1.35e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs710865 0.527 rs2275403 chr1:19557713 C/G cg13387374 chr1:19411106 UBR4 -0.58 -12.81 -0.45 1.34e-33 Brain structure; BRCA trans rs7618501 0.521 rs3796386 chr3:49899795 G/A cg21659725 chr3:3221576 CRBN 0.38 9.26 0.34 2.96e-19 Intelligence (multi-trait analysis); BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.18 -0.49 6.82e-40 Platelet count; BRCA cis rs6089584 0.853 rs1740367 chr20:60574834 C/T cg06108461 chr20:60628389 TAF4 -0.86 -16.26 -0.54 5.49e-50 Body mass index; BRCA cis rs9467773 0.967 rs9461267 chr6:26525455 T/G cg09904177 chr6:26538194 HMGN4 0.57 18.5 0.59 1.62e-61 Intelligence (multi-trait analysis); BRCA cis rs1506636 1.000 rs7357252 chr7:123369856 C/T cg03229431 chr7:123269106 ASB15 -0.61 -13.88 -0.48 1.77e-38 Plateletcrit;Platelet count; BRCA cis rs10911232 0.560 rs10911221 chr1:183046737 G/C ch.1.3577855R chr1:183094577 LAMC1 0.6 15.0 0.51 8.65e-44 Hypertriglyceridemia; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg18402987 chr7:1209562 NA 0.44 9.21 0.34 4.77e-19 Longevity;Endometriosis; BRCA cis rs6964587 0.755 rs13229505 chr7:91444679 G/T cg17063962 chr7:91808500 NA 0.5 11.42 0.41 1.32e-27 Breast cancer; BRCA cis rs11098499 0.954 rs2389803 chr4:120393511 A/G cg09307838 chr4:120376055 NA -0.76 -16.42 -0.54 8.19e-51 Corneal astigmatism; BRCA cis rs2762353 0.935 rs2328895 chr6:25802083 C/T cg12310025 chr6:25882481 NA -0.51 -12.13 -0.43 1.32e-30 Blood metabolite levels; BRCA cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.43 9.56 0.35 2.43e-20 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg12310025 chr6:25882481 NA -0.54 -12.31 -0.44 2.07e-31 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.575 rs10444564 chr12:38043782 T/C cg26384229 chr12:38710491 ALG10B 0.76 16.91 0.56 2.6e-53 Bladder cancer; BRCA cis rs4665809 1.000 rs1470097 chr2:26312840 A/G cg27170947 chr2:26402098 FAM59B -0.66 -11.62 -0.42 1.91e-28 Gut microbiome composition (summer); BRCA cis rs11098499 0.708 rs10005237 chr4:120237897 T/C cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA cis rs861020 0.604 rs3766612 chr1:210020013 G/T cg05527609 chr1:210001259 C1orf107 -0.73 -17.79 -0.58 8.04e-58 Orofacial clefts; BRCA cis rs6964587 1.000 rs13231820 chr7:91663529 A/G cg17063962 chr7:91808500 NA 0.55 12.36 0.44 1.24e-31 Breast cancer; BRCA cis rs6499188 0.522 rs8046299 chr16:68672346 G/A cg02972257 chr16:68554789 NA -0.47 -8.96 -0.33 3.49e-18 Ulcerative colitis; BRCA cis rs6540559 0.673 rs17015224 chr1:209968918 G/A cg22029157 chr1:209979665 IRF6 0.54 11.09 0.4 3.01e-26 Cleft lip with or without cleft palate; BRCA cis rs875971 0.862 rs7796162 chr7:65745758 T/C cg18876405 chr7:65276391 NA -0.51 -11.49 -0.41 6.61e-28 Aortic root size; BRCA cis rs4665809 0.627 rs1465720 chr2:26412638 G/T cg27170947 chr2:26402098 FAM59B -0.93 -16.98 -0.56 1.25e-53 Gut microbiome composition (summer); BRCA cis rs1997103 1.000 rs4948012 chr7:55412578 A/C cg17469321 chr7:55412551 NA 0.49 9.31 0.35 1.98e-19 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2839186 0.526 rs2839297 chr21:47921839 A/G cg13126279 chr21:47581558 C21orf56 -0.38 -8.3 -0.31 6.03e-16 Testicular germ cell tumor; BRCA cis rs1707322 1.000 rs10890359 chr1:46336635 A/G cg03146154 chr1:46216737 IPP 0.45 9.99 0.37 6.35e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs17345786 0.511 rs13061565 chr3:101392270 T/C cg12386194 chr3:101231763 SENP7 0.45 9.53 0.35 3.27e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs9868809 0.505 rs9882549 chr3:48749358 C/T cg00383909 chr3:49044727 WDR6 0.58 11.05 0.4 4.4e-26 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs6835098 1.000 rs4695826 chr4:174089426 T/G cg08422745 chr4:174089978 GALNT7 -0.81 -18.01 -0.58 5.69e-59 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs425277 0.585 rs364677 chr1:2071765 A/G cg24578937 chr1:2090814 PRKCZ -0.37 -11.8 -0.42 3.21e-29 Height; BRCA cis rs7178424 0.935 rs8034216 chr15:62287528 A/G cg00456672 chr15:62358751 C2CD4A 0.42 9.59 0.35 1.98e-20 Height; BRCA cis rs4268898 0.610 rs55860688 chr2:24451534 T/C cg06627628 chr2:24431161 ITSN2 -0.79 -14.73 -0.5 1.73e-42 Asthma; BRCA cis rs10791097 0.694 rs7107595 chr11:130758556 C/T cg12179176 chr11:130786555 SNX19 0.73 18.19 0.58 6.95e-60 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs3857536 0.544 rs208453 chr6:66906841 A/T cg07460842 chr6:66804631 NA -0.56 -10.14 -0.37 1.62e-22 Blood trace element (Cu levels); BRCA trans rs11039798 0.841 rs11500573 chr11:48713900 T/G cg15704280 chr7:45808275 SEPT13 0.59 8.8 0.33 1.26e-17 Axial length; BRCA cis rs727479 0.543 rs3759811 chr15:51529265 A/G cg19946085 chr15:51559439 CYP19A1 -0.28 -8.02 -0.3 5.02e-15 Estradiol levels; BRCA cis rs1018836 0.923 rs62526886 chr8:91627676 G/A cg16814680 chr8:91681699 NA -0.6 -12.83 -0.45 1.05e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs1707322 0.827 rs6683274 chr1:46241638 T/G cg03146154 chr1:46216737 IPP 0.51 11.25 0.41 6.28e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.861 rs6990796 chr8:58183097 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs2197308 0.565 rs12809769 chr12:37909968 C/T cg13010199 chr12:38710504 ALG10B 0.51 9.99 0.37 6.28e-22 Morning vs. evening chronotype; BRCA cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg17554472 chr22:41940697 POLR3H -0.42 -7.9 -0.3 1.22e-14 Vitiligo; BRCA cis rs9790314 0.612 rs9875200 chr3:160733708 A/G cg03342759 chr3:160939853 NMD3 -0.44 -9.13 -0.34 8.97e-19 Morning vs. evening chronotype; BRCA cis rs9467773 1.000 rs6930120 chr6:26555484 A/G cg09904177 chr6:26538194 HMGN4 0.55 17.67 0.57 3.26e-57 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.836 rs6142294 chr20:33671497 A/G cg24642439 chr20:33292090 TP53INP2 -0.44 -8.7 -0.33 2.78e-17 Height; BRCA cis rs17384381 1.000 rs35193119 chr1:85859265 T/C cg16011679 chr1:85725395 C1orf52 0.53 8.18 0.31 1.51e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4076764 0.914 rs6689760 chr1:163358704 A/G cg06092702 chr1:163392909 NA 0.35 9.27 0.34 2.82e-19 Motion sickness; BRCA cis rs56104184 0.779 rs17272666 chr19:49356294 T/C cg15549821 chr19:49342101 PLEKHA4 -0.98 -15.18 -0.51 1.09e-44 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7737355 0.947 rs10054733 chr5:130989426 C/T cg06307176 chr5:131281290 NA 0.53 10.34 0.38 2.81e-23 Life satisfaction; BRCA cis rs6089584 1.000 rs6089581 chr20:60562394 G/A cg06108461 chr20:60628389 TAF4 -0.79 -17.05 -0.56 5.51e-54 Body mass index; BRCA cis rs60871478 1.000 rs62432251 chr7:801855 T/G cg27478167 chr7:817139 HEATR2 -0.48 -9.96 -0.37 8.3e-22 Cerebrospinal P-tau181p levels; BRCA trans rs6479891 1.000 rs12413415 chr10:64919511 T/C cg14819942 chr15:35414228 NA 0.35 8.63 0.32 5.03e-17 Arthritis (juvenile idiopathic); BRCA trans rs1005277 0.579 rs2505197 chr10:38393310 T/C cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.69e-17 Extrinsic epigenetic age acceleration; BRCA cis rs317689 0.684 rs315125 chr12:69758884 C/T cg14784868 chr12:69753453 YEATS4 0.48 9.59 0.35 2e-20 Response to diuretic therapy; BRCA cis rs7395581 0.877 rs10838690 chr11:47335075 A/G cg25783544 chr11:47291846 MADD 0.42 9.55 0.35 2.78e-20 HDL cholesterol; BRCA cis rs7772486 0.754 rs9497419 chr6:146142609 T/C cg05347473 chr6:146136440 FBXO30 0.38 7.86 0.3 1.61e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs2882667 1.000 rs10064201 chr5:138309405 C/T cg04439458 chr5:138467593 SIL1 -0.36 -9.66 -0.36 1.02e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs11690935 0.959 rs7572215 chr2:172634228 G/A cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.7 -0.77 7.24e-128 Schizophrenia; BRCA cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg01877450 chr7:97915802 BRI3 -0.39 -8.92 -0.33 5.01e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.798 rs17708218 chr2:99696284 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.78 -0.5 9.3e-43 Chronic sinus infection; BRCA cis rs6430585 0.528 rs309162 chr2:136690783 T/A cg07169764 chr2:136633963 MCM6 1.1 22.03 0.66 1.84e-80 Corneal structure; BRCA trans rs11250097 0.507 rs2409779 chr8:11311340 A/T cg15556689 chr8:8085844 FLJ10661 -0.42 -10.55 -0.39 4.34e-24 Neuroticism; BRCA cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg26597838 chr10:835615 NA 0.81 14.47 0.5 2.94e-41 Eosinophil percentage of granulocytes; BRCA cis rs73086581 0.786 rs6037705 chr20:3952830 G/C cg02187196 chr20:3869020 PANK2 0.45 8.27 0.31 7.94e-16 Response to antidepressants in depression; BRCA cis rs9733 0.596 rs2175615 chr1:150624101 A/G cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 5.1e-16 Tonsillectomy; BRCA cis rs13108904 0.517 rs13134568 chr4:1334289 G/A cg13395646 chr4:1353034 KIAA1530 -0.49 -9.03 -0.34 2e-18 Obesity-related traits; BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg16606324 chr3:10149918 C3orf24 0.54 10.48 0.38 8.25e-24 Alzheimer's disease; BRCA cis rs701145 0.537 rs1713847 chr3:153791107 C/A cg17054900 chr3:154042577 DHX36 0.53 9.19 0.34 5.62e-19 Coronary artery disease; BRCA cis rs6840360 0.554 rs58751443 chr4:152709905 A/G cg22705602 chr4:152727874 NA -0.4 -10.77 -0.39 5.74e-25 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs7281767 chr21:32022062 T/C cg16431978 chr21:31797932 KRTAP13-3 0.35 8.98 0.33 3.03e-18 HDL cholesterol; BRCA cis rs2842992 0.672 rs4708845 chr6:160219601 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 17.83 0.58 5.12e-58 Age-related macular degeneration (geographic atrophy); BRCA cis rs4819052 0.851 rs8130285 chr21:46671701 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.27 0.46 1.14e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs597539 0.689 rs596874 chr11:68630874 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.69 -16.47 -0.55 4.78e-51 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs651907 0.557 rs2303474 chr3:101371899 G/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.53 12.76 0.45 2.26e-33 Colorectal cancer; BRCA cis rs17641971 0.684 rs4873094 chr8:49989578 G/T cg00325661 chr8:49890786 NA 0.39 10.81 0.39 4.14e-25 Blood metabolite levels; BRCA cis rs7647973 0.710 rs6446284 chr3:49616997 A/G cg07636037 chr3:49044803 WDR6 0.55 8.7 0.33 2.75e-17 Menarche (age at onset); BRCA cis rs1401999 1.000 rs6767013 chr3:183680102 G/A cg20387954 chr3:183756860 HTR3D 0.45 10.03 0.37 4.19e-22 Anterior chamber depth; BRCA cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg17971929 chr21:40555470 PSMG1 -0.47 -10.39 -0.38 1.87e-23 Menarche (age at onset); BRCA cis rs17376456 0.825 rs34967135 chr5:93221785 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.47 0.32 1.67e-16 Diabetic retinopathy; BRCA cis rs1862618 0.802 rs2591949 chr5:56132627 T/C cg24549020 chr5:56110836 MAP3K1 0.66 13.46 0.47 1.47e-36 Initial pursuit acceleration; BRCA cis rs2032447 0.966 rs7756117 chr6:26046565 A/G cg12310025 chr6:25882481 NA 0.42 9.73 0.36 6.08e-21 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs4240867 chr1:152954921 A/G cg21543102 chr1:152974771 SPRR3 0.3 8.86 0.33 8.13e-18 Inflammatory skin disease; BRCA cis rs1707322 1.000 rs1768817 chr1:46514534 C/G cg03146154 chr1:46216737 IPP -0.44 -9.78 -0.36 3.68e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7264396 0.563 rs2425117 chr20:34323776 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.95 -0.43 7.49e-30 Total cholesterol levels; BRCA cis rs7727544 0.545 rs10074490 chr5:131340032 C/T cg14196790 chr5:131705035 SLC22A5 0.31 8.0 0.3 5.93e-15 Blood metabolite levels; BRCA trans rs4689592 0.503 rs59640165 chr4:7051661 G/A cg07817883 chr1:32538562 TMEM39B 0.55 8.84 0.33 9.31e-18 Monocyte percentage of white cells; BRCA cis rs2625529 0.824 rs4777480 chr15:72328997 A/C cg16672083 chr15:72433130 SENP8 -0.84 -17.84 -0.58 4.44e-58 Red blood cell count; BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg19010396 chr19:19431384 KIAA0892;SF4 -0.44 -8.77 -0.33 1.55e-17 Tonsillectomy; BRCA cis rs12142240 0.667 rs45524035 chr1:46862780 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.58 0.35 2.16e-20 Menopause (age at onset); BRCA trans rs7980799 0.935 rs4931717 chr12:33521151 A/G cg26384229 chr12:38710491 ALG10B 0.4 8.41 0.32 2.73e-16 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg18479299 chr3:125709523 NA -0.53 -8.14 -0.31 2.03e-15 Blood pressure (smoking interaction); BRCA cis rs3806843 0.676 rs2569159 chr5:140030710 C/T cg16179182 chr5:140090404 VTRNA1-1 0.47 10.89 0.4 1.91e-25 Depressive symptoms (multi-trait analysis); BRCA cis rs3096299 0.933 rs2965823 chr16:89454924 G/A cg06640241 chr16:89574553 SPG7 0.59 12.97 0.46 2.54e-34 Multiple myeloma (IgH translocation); BRCA cis rs11250464 0.724 rs4614361 chr10:1410394 A/G cg08668359 chr10:1443807 ADARB2 0.41 8.16 0.31 1.79e-15 Radiation response; BRCA cis rs868036 0.957 rs9920662 chr15:68104297 G/A cg08079166 chr15:68083412 MAP2K5 0.35 9.46 0.35 5.8e-20 Restless legs syndrome; BRCA cis rs11098499 0.754 rs1849457 chr4:120254355 A/G cg09307838 chr4:120376055 NA 0.63 13.26 0.46 1.29e-35 Corneal astigmatism; BRCA trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21659725 chr3:3221576 CRBN -0.47 -9.94 -0.37 9.53e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs13256369 0.851 rs13256611 chr8:8564341 G/A cg06671706 chr8:8559999 CLDN23 0.45 8.76 0.33 1.69e-17 Obesity-related traits; BRCA cis rs17384381 1.000 rs12140457 chr1:85860170 G/A cg16011679 chr1:85725395 C1orf52 0.53 8.15 0.31 1.86e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2652834 1.000 rs2729780 chr15:63404639 C/G cg05507819 chr15:63340323 TPM1 0.45 8.34 0.31 4.49e-16 HDL cholesterol; BRCA cis rs6977660 0.619 rs10263780 chr7:19778086 A/G cg07541023 chr7:19748670 TWISTNB -0.55 -9.88 -0.36 1.65e-21 Thyroid stimulating hormone; BRCA cis rs72615157 0.612 rs7786505 chr7:99817585 G/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.51 8.32 0.31 5.45e-16 Lung function (FEV1/FVC); BRCA cis rs11634851 1.000 rs11638879 chr15:81030214 A/G cg03950166 chr15:80988613 FAM108C1 0.35 7.84 0.3 1.91e-14 Systolic blood pressure; BRCA cis rs1882538 0.596 rs10281827 chr7:133081810 A/G cg10665199 chr7:133106180 EXOC4 0.46 9.9 0.36 1.33e-21 Intelligence (multi-trait analysis); BRCA cis rs977987 0.835 rs8046109 chr16:75360096 A/G cg03315344 chr16:75512273 CHST6 0.54 12.78 0.45 1.73e-33 Dupuytren's disease; BRCA trans rs11098499 0.530 rs114866537 chr4:120258608 A/T cg25214090 chr10:38739885 LOC399744 0.43 10.17 0.37 1.3e-22 Corneal astigmatism; BRCA cis rs57590327 0.528 rs13086292 chr3:81705368 G/A cg07356753 chr3:81810745 GBE1 -0.43 -9.85 -0.36 2.16e-21 Extraversion; BRCA cis rs16958440 1.000 rs62096478 chr18:44662409 A/G cg17192377 chr18:44677553 HDHD2 0.69 10.1 0.37 2.41e-22 Sitting height ratio; BRCA cis rs2046867 0.862 rs62251657 chr3:72832076 C/T cg25664220 chr3:72788482 NA -0.53 -10.88 -0.4 2.13e-25 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs1153858 1.000 rs12441971 chr15:45671957 A/T cg21132104 chr15:45694354 SPATA5L1 0.75 16.9 0.56 2.9e-53 Homoarginine levels; BRCA trans rs11088226 0.581 rs2016103 chr21:33878030 G/A cg09050820 chr6:167586206 TCP10L2 0.38 7.85 0.3 1.72e-14 Gastritis; BRCA cis rs13040088 0.872 rs2295481 chr20:61574727 C/T cg23096297 chr20:61557774 DIDO1 0.9 17.35 0.57 1.55e-55 Menopause (age at onset); BRCA cis rs16854884 0.586 rs7611326 chr3:143736374 C/T cg06585982 chr3:143692056 C3orf58 0.51 10.64 0.39 1.89e-24 Economic and political preferences (feminism/equality); BRCA cis rs4595586 0.545 rs12823586 chr12:39391677 C/G cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs7267979 0.903 rs6115109 chr20:25239667 G/A cg08601574 chr20:25228251 PYGB 0.41 9.61 0.36 1.64e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10751667 0.666 rs6597957 chr11:982294 T/A cg01483505 chr11:975446 AP2A2 0.3 8.01 0.3 5.5e-15 Alzheimer's disease (late onset); BRCA trans rs6089829 0.962 rs4809455 chr20:61660781 G/C cg17470723 chr8:74884337 TCEB1 0.41 8.82 0.33 1.06e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs503734 0.521 rs348884 chr3:100975293 C/G cg27318481 chr3:100970896 IMPG2 -0.41 -9.88 -0.36 1.66e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10416265 0.528 rs3786932 chr19:33620488 T/A cg17764715 chr19:33622953 WDR88 0.51 8.13 0.31 2.26e-15 Bone properties (heel); BRCA cis rs1348850 0.526 rs2178017 chr2:178374788 G/T cg27490568 chr2:178487706 NA 0.5 8.27 0.31 7.6e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs897984 0.542 rs8061047 chr16:31068960 T/C cg02466173 chr16:30829666 NA -0.43 -9.64 -0.36 1.29e-20 Dementia with Lewy bodies; BRCA cis rs7927771 0.524 rs11039377 chr11:47789776 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.54 0.35 2.88e-20 Subjective well-being; BRCA cis rs1595825 0.891 rs77946222 chr2:198533251 C/T cg19156104 chr2:198669113 PLCL1 -0.46 -8.59 -0.32 6.88e-17 Ulcerative colitis; BRCA trans rs11098499 0.866 rs12513310 chr4:120288039 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs6570726 0.791 rs12205752 chr6:145896118 A/G cg23711669 chr6:146136114 FBXO30 0.74 17.75 0.57 1.29e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs7447593 0.518 rs4074995 chr5:176797343 C/T cg17509989 chr5:176798049 RGS14 0.94 19.57 0.61 3.37e-67 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg02476566 chr12:106696527 TCP11L2 0.5 9.39 0.35 1e-19 Tourette syndrome; BRCA cis rs7131987 0.903 rs11050163 chr12:29420398 C/T cg09582351 chr12:29534625 ERGIC2 -0.39 -9.49 -0.35 4.67e-20 QT interval; BRCA cis rs875971 0.965 rs6971509 chr7:65714970 G/T cg18876405 chr7:65276391 NA -0.55 -12.95 -0.46 3.03e-34 Aortic root size; BRCA cis rs2836950 0.565 rs2150414 chr21:40614988 A/G cg06238570 chr21:40685208 BRWD1 -0.4 -8.24 -0.31 9.95e-16 Menarche (age at onset); BRCA cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs35306767 0.714 rs12777800 chr10:1070361 G/A cg20503657 chr10:835505 NA 0.9 13.51 0.47 9.42e-37 Eosinophil percentage of granulocytes; BRCA cis rs7917772 0.599 rs2863717 chr10:104519829 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -10.35 -0.38 2.58e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9733 0.628 rs72700895 chr1:150626029 C/T cg18016565 chr1:150552671 MCL1 0.35 8.24 0.31 1.01e-15 Tonsillectomy; BRCA trans rs11989744 0.597 rs11135768 chr8:23573278 A/G cg03492747 chr16:86543808 FOXF1 0.43 10.68 0.39 1.34e-24 Waist-hip ratio; BRCA cis rs2762353 0.808 rs1185153 chr6:25834548 A/G cg03517284 chr6:25882590 NA -0.51 -11.52 -0.41 5.1e-28 Blood metabolite levels; BRCA cis rs9733 0.744 rs2039590 chr1:150813315 G/A cg18016565 chr1:150552671 MCL1 -0.39 -8.85 -0.33 8.88e-18 Tonsillectomy; BRCA cis rs7264396 0.887 rs224362 chr20:34062642 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.4 -8.43 -0.32 2.22e-16 Total cholesterol levels; BRCA cis rs6087990 0.806 rs910085 chr20:31383353 T/G cg13636640 chr20:31349939 DNMT3B 0.65 20.7 0.63 3.29e-73 Ulcerative colitis; BRCA cis rs9660992 0.674 rs1151785 chr1:205232299 C/T cg00857998 chr1:205179979 DSTYK 0.44 8.33 0.31 4.82e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs6882046 0.513 rs628158 chr5:88041781 G/A cg22951263 chr5:87985283 NA -0.38 -10.65 -0.39 1.75e-24 Intelligence (multi-trait analysis);Educational attainment (years of education);Neuroticism;Educational attainment (college completion);Educational attainment; BRCA cis rs3125734 0.572 rs7896627 chr10:64046354 T/G cg19640130 chr10:64028056 RTKN2 -0.33 -9.05 -0.34 1.64e-18 Rheumatoid arthritis; BRCA cis rs35146811 0.555 rs1981549 chr7:99541636 A/G cg22906224 chr7:99728672 NA 0.43 7.93 0.3 9.58e-15 Coronary artery disease; BRCA cis rs6933660 0.676 rs3757316 chr6:151774339 A/G cg10883421 chr6:151773342 RMND1;C6orf211 -0.4 -8.7 -0.33 2.82e-17 Menarche (age at onset); BRCA cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg06671706 chr8:8559999 CLDN23 0.45 8.63 0.32 4.86e-17 Obesity-related traits; BRCA cis rs35110281 0.774 rs9978811 chr21:44998683 C/T cg21573476 chr21:45109991 RRP1B -0.35 -9.24 -0.34 3.62e-19 Mean corpuscular volume; BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg08888203 chr3:10149979 C3orf24 0.65 11.97 0.43 6.05e-30 Alzheimer's disease; BRCA cis rs9487051 0.872 rs9480922 chr6:109607211 G/A cg21918786 chr6:109611834 NA -0.48 -14.03 -0.49 3.57e-39 Reticulocyte fraction of red cells; BRCA cis rs8114671 0.586 rs734111 chr20:33533736 A/C cg07148914 chr20:33460835 GGT7 0.49 10.33 0.38 3.06e-23 Height; BRCA cis rs10751667 0.600 rs6597948 chr11:1005308 C/T cg20946044 chr11:1010712 AP2A2 -0.37 -7.93 -0.3 9.63e-15 Alzheimer's disease (late onset); BRCA cis rs2046867 0.818 rs17010215 chr3:72886965 A/G cg25664220 chr3:72788482 NA -0.55 -11.84 -0.42 2.31e-29 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs877529 0.967 rs139410 chr22:39552597 A/G cg18708252 chr22:39545030 CBX7 -0.31 -8.17 -0.31 1.62e-15 Multiple myeloma; BRCA trans rs1994135 0.630 rs11052760 chr12:33724949 A/T cg13010199 chr12:38710504 ALG10B 0.42 7.92 0.3 1.05e-14 Resting heart rate; BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.27 8.77 0.33 1.61e-17 Electroencephalogram traits; BRCA cis rs1707322 0.964 rs1707339 chr1:46513179 A/G cg03146154 chr1:46216737 IPP -0.44 -9.78 -0.36 3.68e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 0.717 rs1972410 chr1:46080947 G/T cg03146154 chr1:46216737 IPP 0.48 10.73 0.39 8.59e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg22535103 chr8:58192502 C8orf71 -0.54 -9.18 -0.34 6.01e-19 Developmental language disorder (linguistic errors); BRCA cis rs1691799 0.867 rs1168344 chr12:66758213 G/A cg16791601 chr12:66731901 HELB -0.66 -17.99 -0.58 7.66e-59 White blood cell count (basophil); BRCA cis rs7809950 0.773 rs62483722 chr7:107186349 C/T cg23024343 chr7:107201750 COG5 -0.39 -8.96 -0.33 3.55e-18 Coronary artery disease; BRCA cis rs6121246 0.559 rs6121243 chr20:30415094 C/G cg13852791 chr20:30311386 BCL2L1 0.95 22.78 0.67 1.47e-84 Mean corpuscular hemoglobin; BRCA cis rs2153535 0.601 rs2143352 chr6:8530248 G/C cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.59e-19 Motion sickness; BRCA cis rs3733585 0.699 rs6823361 chr4:9963127 A/G cg11266682 chr4:10021025 SLC2A9 -0.41 -10.83 -0.39 3.35e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg24399712 chr22:39784796 NA 0.58 12.22 0.44 5.36e-31 Intelligence (multi-trait analysis); BRCA cis rs6545883 0.894 rs778157 chr2:61554289 C/G cg15711740 chr2:61764176 XPO1 -0.51 -12.98 -0.46 2.26e-34 Tuberculosis; BRCA cis rs2404602 0.684 rs12591622 chr15:76930655 A/T cg23625390 chr15:77176239 SCAPER -0.54 -12.75 -0.45 2.58e-33 Blood metabolite levels; BRCA cis rs4689388 0.926 rs4688986 chr4:6285797 C/A cg00701064 chr4:6280414 WFS1 0.7 19.41 0.61 2.52e-66 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs11098499 0.691 rs10010355 chr4:120261043 A/G cg09307838 chr4:120376055 NA 0.58 12.69 0.45 4.73e-33 Corneal astigmatism; BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg21782813 chr7:2030301 MAD1L1 0.42 11.41 0.41 1.46e-27 Bipolar disorder and schizophrenia; BRCA cis rs2832191 0.646 rs2832214 chr21:30517127 C/T cg08807101 chr21:30365312 RNF160 -0.43 -9.19 -0.34 5.26e-19 Dental caries; BRCA trans rs10028773 0.556 rs4473640 chr4:120260437 G/A cg25214090 chr10:38739885 LOC399744 0.43 10.02 0.37 4.62e-22 Educational attainment; BRCA cis rs10751667 1.000 rs6597972 chr11:928402 C/T cg06064525 chr11:970664 AP2A2 -0.33 -9.65 -0.36 1.2e-20 Alzheimer's disease (late onset); BRCA cis rs1003719 0.788 rs7277657 chr21:38469523 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2304069 0.954 rs4705408 chr5:149412545 A/G cg10852222 chr5:149380144 HMGXB3;TIGD6 -0.56 -8.69 -0.33 2.95e-17 HIV-1 control; BRCA cis rs2153535 0.505 rs1737583 chr6:8536812 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.03 0.49 3.53e-39 Motion sickness; BRCA cis rs858239 0.539 rs4377861 chr7:23185969 C/T cg23682824 chr7:23144976 KLHL7 0.37 9.48 0.35 4.86e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs11690935 0.788 rs6715929 chr2:172877507 A/G cg13550731 chr2:172543902 DYNC1I2 -0.73 -21.29 -0.64 1.91e-76 Schizophrenia; BRCA cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg17063962 chr7:91808500 NA -0.53 -12.33 -0.44 1.78e-31 Breast cancer; BRCA cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg06238570 chr21:40685208 BRWD1 -0.41 -8.36 -0.31 4.05e-16 Menarche (age at onset); BRCA cis rs7903847 0.642 rs9888117 chr10:99159963 C/G cg20016023 chr10:99160130 RRP12 -0.24 -7.95 -0.3 8.22e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs9443645 0.869 rs9343827 chr6:79501036 A/G cg11833968 chr6:79620685 NA -0.42 -9.24 -0.34 3.68e-19 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs17558151 chr4:99048699 T/C cg03676636 chr4:99064102 C4orf37 0.21 7.94 0.3 9.23e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs113835537 0.529 rs79798028 chr11:66199362 T/G cg24851651 chr11:66362959 CCS 0.42 8.05 0.3 4.1e-15 Airway imaging phenotypes; BRCA cis rs290268 0.874 rs290988 chr9:93562955 C/G cg02608019 chr9:93564028 SYK 0.55 12.23 0.44 4.54e-31 Platelet count; BRCA cis rs28374715 0.532 rs11854820 chr15:41676526 G/A cg18705301 chr15:41695430 NDUFAF1 -1.09 -24.82 -0.7 9.65e-96 Ulcerative colitis; BRCA cis rs67981189 0.513 rs2526856 chr14:71412717 A/G cg15816911 chr14:71606274 NA 0.38 8.26 0.31 8.59e-16 Schizophrenia; BRCA cis rs8180040 0.620 rs9858443 chr3:47086048 G/A cg16586182 chr3:47516702 SCAP -0.55 -12.44 -0.44 5.89e-32 Colorectal cancer; BRCA cis rs11711311 1.000 rs10934243 chr3:113430239 T/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.39 10.31 0.38 3.7e-23 IgG glycosylation; BRCA cis rs1534166 0.602 rs3817524 chr3:133526403 C/T cg27366882 chr3:133540807 NA -0.34 -8.26 -0.31 8.3e-16 Alcohol consumption (transferrin glycosylation); BRCA cis rs2011503 1.000 rs80007081 chr19:19626734 A/G cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.47 0.38 8.99e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs270601 0.909 rs2569265 chr5:131704519 T/C cg24060327 chr5:131705240 SLC22A5 0.6 11.36 0.41 2.32e-27 Acylcarnitine levels; BRCA cis rs2554380 0.943 rs2585061 chr15:84347751 A/G cg14598478 chr15:84363061 ADAMTSL3 -0.32 -7.87 -0.3 1.56e-14 Height; BRCA cis rs6912958 0.684 rs6931069 chr6:88367082 C/T cg08069147 chr6:88032118 GJB7;C6orf162 -0.42 -8.55 -0.32 8.75e-17 Monocyte percentage of white cells; BRCA cis rs9393777 0.513 rs6913660 chr6:27091425 C/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -8.4 -0.32 2.95e-16 Intelligence (multi-trait analysis); BRCA trans rs1997103 1.000 rs1997098 chr7:55405594 G/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2777491 1.000 rs66538814 chr15:41685917 G/T cg18705301 chr15:41695430 NDUFAF1 -0.64 -15.02 -0.51 6.91e-44 Ulcerative colitis; BRCA cis rs910316 1.000 rs10149880 chr14:75633008 A/G cg23033748 chr14:75592666 NEK9 -0.42 -10.03 -0.37 4.54e-22 Height; BRCA cis rs9814567 1.000 rs7371896 chr3:134249769 C/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.31 -7.85 -0.3 1.79e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7301826 0.967 rs4759790 chr12:131296390 T/G cg11011512 chr12:131303247 STX2 0.42 10.78 0.39 4.99e-25 Plasma plasminogen activator levels; BRCA cis rs7666738 0.830 rs1967979 chr4:98966201 G/T cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs13256369 1.000 rs10095733 chr8:8574646 A/G cg00074818 chr8:8560427 CLDN23 0.36 8.0 0.3 5.98e-15 Obesity-related traits; BRCA cis rs7847628 0.587 rs4837796 chr9:123610288 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.93 -26.13 -0.72 6.44e-103 Birth weight; BRCA cis rs10751667 0.666 rs4074233 chr11:977685 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.55 0.55 1.84e-51 Alzheimer's disease (late onset); BRCA cis rs7582180 0.764 rs11691684 chr2:100921776 T/A cg14675211 chr2:100938903 LONRF2 0.46 10.58 0.39 3.25e-24 Intelligence (multi-trait analysis); BRCA cis rs7178375 0.607 rs7171212 chr15:31207711 C/T cg06792044 chr15:31234080 MTMR10;MTMR15 -0.59 -8.26 -0.31 8.56e-16 Hypertriglyceridemia; BRCA cis rs9733 0.544 rs72700902 chr1:150633347 C/T cg17724175 chr1:150552817 MCL1 0.26 8.52 0.32 1.12e-16 Tonsillectomy; BRCA cis rs40363 0.951 rs250632 chr16:3523047 C/T cg05754148 chr16:3507555 NAT15 0.55 8.14 0.31 2.02e-15 Tuberculosis; BRCA cis rs9291683 0.655 rs35750364 chr4:10049049 T/C cg00071950 chr4:10020882 SLC2A9 0.63 15.59 0.52 1.14e-46 Bone mineral density; BRCA cis rs796364 0.906 rs6740981 chr2:201060216 T/C cg23649088 chr2:200775458 C2orf69 0.62 10.87 0.39 2.3e-25 Schizophrenia; BRCA cis rs11690935 1.000 rs34542126 chr2:172542705 C/T cg13550731 chr2:172543902 DYNC1I2 0.94 32.19 0.79 7.76e-136 Schizophrenia; BRCA cis rs7631605 0.905 rs7639327 chr3:37099788 A/G cg15934958 chr3:37212084 LRRFIP2 0.47 10.8 0.39 4.28e-25 Cerebrospinal P-tau181p levels; BRCA cis rs11958404 0.932 rs12517979 chr5:157428918 T/C cg05962755 chr5:157440814 NA 0.55 10.4 0.38 1.66e-23 IgG glycosylation; BRCA trans rs1005277 0.579 rs1740747 chr10:38520465 G/A cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.63e-33 Extrinsic epigenetic age acceleration; BRCA cis rs12497850 0.897 rs7373778 chr3:48836392 C/G cg07636037 chr3:49044803 WDR6 0.98 29.08 0.75 4.44e-119 Parkinson's disease; BRCA cis rs9814567 1.000 rs7427492 chr3:134261654 C/T cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.96 -0.3 7.72e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12368653 0.607 rs7966795 chr12:58031413 C/A cg18357645 chr12:58087776 OS9 0.35 9.33 0.35 1.73e-19 Multiple sclerosis; BRCA cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg08219700 chr8:58056026 NA 0.47 8.44 0.32 2.14e-16 Developmental language disorder (linguistic errors); BRCA cis rs12971120 0.891 rs3794955 chr18:72174827 C/T cg25817165 chr18:72167213 CNDP2 -0.71 -12.85 -0.45 8.76e-34 Refractive error; BRCA cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.23 -0.38 7.23e-23 Initial pursuit acceleration; BRCA cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg24562669 chr7:97807699 LMTK2 0.45 12.23 0.44 4.67e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs4665809 0.590 rs7260 chr2:26413917 C/T cg08067268 chr2:26466485 HADHB;HADHA -0.51 -9.42 -0.35 7.89e-20 Gut microbiome composition (summer); BRCA cis rs3793683 0.965 rs3829131 chr10:134564627 A/G cg26818010 chr10:134567672 INPP5A 0.39 9.24 0.34 3.65e-19 Migraine; BRCA cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg04553112 chr3:125709451 NA -0.56 -8.53 -0.32 1.08e-16 Blood pressure (smoking interaction); BRCA cis rs274567 0.501 rs272856 chr5:131687081 G/C cg24060327 chr5:131705240 SLC22A5 -0.62 -11.67 -0.42 1.14e-28 Blood metabolite levels; BRCA cis rs17741873 0.836 rs12221230 chr10:75604972 T/C cg07699608 chr10:75541558 CHCHD1 0.56 8.81 0.33 1.16e-17 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs117623576 0.941 rs7098334 chr10:32418501 G/T cg03047570 chr10:32398778 NA -0.58 -8.92 -0.33 4.87e-18 Anti-saccade response; BRCA cis rs11785400 0.793 rs4301430 chr8:143737416 A/G cg10596483 chr8:143751796 JRK 0.39 8.25 0.31 8.98e-16 Schizophrenia; BRCA cis rs911555 0.723 rs6575986 chr14:103886671 G/A cg12935359 chr14:103987150 CKB -0.59 -13.52 -0.47 7.94e-37 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.48 -0.32 1.52e-16 Total body bone mineral density; BRCA cis rs7020830 0.571 rs7031314 chr9:37376122 A/T cg14294708 chr9:37120828 ZCCHC7 -0.87 -16.63 -0.55 7.39e-52 Schizophrenia; BRCA cis rs2839186 0.656 rs8128380 chr21:47665693 C/T cg12379764 chr21:47803548 PCNT -0.38 -8.08 -0.3 3.33e-15 Testicular germ cell tumor; BRCA cis rs9291683 0.530 rs4697698 chr4:9942577 C/T cg11266682 chr4:10021025 SLC2A9 0.41 11.09 0.4 2.82e-26 Bone mineral density; BRCA trans rs8002861 0.967 rs9533691 chr13:44482208 A/G cg17145862 chr1:211918768 LPGAT1 0.69 18.01 0.58 5.82e-59 Leprosy; BRCA cis rs6752107 0.967 rs6431661 chr2:234167421 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.3 0.41 4.02e-27 Crohn's disease;Inflammatory bowel disease; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg14863265 chr7:2801509 GNA12 -0.42 -9.64 -0.36 1.31e-20 Height; BRCA cis rs13102973 1.000 rs13112665 chr4:135898581 C/A cg14419869 chr4:135874104 NA 0.54 11.15 0.4 1.64e-26 Subjective well-being; BRCA cis rs17741873 0.779 rs4746154 chr10:75629396 G/A cg07699608 chr10:75541558 CHCHD1 0.55 8.4 0.32 2.78e-16 Paclitaxel disposition in epithelial ovarian cancer; BRCA cis rs514406 0.505 rs431459 chr1:53183230 T/G cg08859206 chr1:53392774 SCP2 -0.44 -8.81 -0.33 1.16e-17 Monocyte count; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg04944784 chr2:26401820 FAM59B -0.97 -16.48 -0.55 4.21e-51 Gut microbiome composition (summer); BRCA cis rs7631605 0.935 rs2302504 chr3:37116386 A/C cg15934958 chr3:37212084 LRRFIP2 -0.41 -9.71 -0.36 6.71e-21 Cerebrospinal P-tau181p levels; BRCA cis rs1008375 0.932 rs6844593 chr4:17659039 T/C cg16339924 chr4:17578868 LAP3 0.67 16.2 0.54 1.04e-49 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs877282 0.755 rs2790388 chr10:786084 T/C cg22713356 chr15:30763199 NA 1.09 21.63 0.65 3.04e-78 Uric acid levels; BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg00814883 chr7:100076585 TSC22D4 -0.49 -10.26 -0.38 5.9e-23 Platelet count; BRCA cis rs9583531 0.843 rs7999702 chr13:111382264 A/C cg24331049 chr13:111365604 ING1 -0.65 -14.1 -0.49 1.58e-39 Coronary artery disease; BRCA cis rs79057730 0.527 rs34519158 chr7:811114 G/A cg06242242 chr7:766104 PRKAR1B;HEATR2 0.76 10.38 0.38 1.98e-23 Initial pursuit acceleration; BRCA cis rs1506636 0.886 rs6466878 chr7:123272278 T/C cg03229431 chr7:123269106 ASB15 -0.68 -15.83 -0.53 7.21e-48 Plateletcrit;Platelet count; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg11814155 chr7:99998594 ZCWPW1 0.56 9.49 0.35 4.41e-20 Platelet count; BRCA cis rs1577917 0.958 rs12196230 chr6:86519960 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.8 -0.42 3.43e-29 Response to antipsychotic treatment; BRCA cis rs2072499 0.966 rs6427307 chr1:156190083 A/G cg24450063 chr1:156163899 SLC25A44 1.08 33.77 0.8 3.07e-144 Testicular germ cell tumor; BRCA cis rs7819412 0.645 rs10156356 chr8:11046209 T/C cg21775007 chr8:11205619 TDH -0.5 -10.39 -0.38 1.87e-23 Triglycerides; BRCA cis rs1669338 0.507 rs4685609 chr3:3202279 T/C cg16797762 chr3:3221439 CRBN -0.65 -9.95 -0.37 8.55e-22 White matter integrity; BRCA cis rs7394190 0.748 rs11000773 chr10:75534115 G/T cg07699608 chr10:75541558 CHCHD1 0.65 9.64 0.36 1.26e-20 Incident atrial fibrillation; BRCA cis rs16854884 0.770 rs13091882 chr3:143818661 C/T cg06585982 chr3:143692056 C3orf58 0.41 7.96 0.3 7.68e-15 Economic and political preferences (feminism/equality); BRCA cis rs12477438 0.520 rs4588238 chr2:99749350 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.78 0.67 1.54e-84 Chronic sinus infection; BRCA cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg00101154 chr16:420108 MRPL28 -0.48 -11.73 -0.42 6.43e-29 Bone mineral density (spine);Bone mineral density; BRCA cis rs730775 0.505 rs325001 chr6:44270936 A/G cg21130236 chr6:44246755 TMEM151B 0.29 8.26 0.31 8.34e-16 Monocyte percentage of white cells;Monocyte count; BRCA cis rs12134245 0.747 rs11164929 chr1:92012836 G/C cg25838465 chr1:92012736 NA -0.68 -19.97 -0.62 2.66e-69 Breast cancer; BRCA cis rs6484504 0.600 rs366758 chr11:31222499 A/C cg26647111 chr11:31128758 NA -0.44 -9.67 -0.36 9.59e-21 Red blood cell count; BRCA cis rs2276314 0.857 rs62101402 chr18:33629435 A/G cg05985134 chr18:33552581 C18orf21 0.64 12.25 0.44 3.81e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7772486 0.632 rs9386128 chr6:146049053 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -16.94 -0.56 2e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs11955398 0.647 rs57521726 chr5:59984897 A/T cg02684056 chr5:59996105 DEPDC1B 0.39 9.02 0.34 2.25e-18 Intelligence (multi-trait analysis); BRCA trans rs7819412 0.595 rs4841500 chr8:10988275 A/G cg06636001 chr8:8085503 FLJ10661 -0.49 -10.1 -0.37 2.36e-22 Triglycerides; BRCA cis rs13118159 0.778 rs12640984 chr4:1338834 G/A cg05025164 chr4:1340916 KIAA1530 0.37 8.34 0.31 4.66e-16 Longevity; BRCA cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg04990556 chr1:26633338 UBXN11 -0.74 -18.31 -0.59 1.61e-60 Obesity-related traits; BRCA cis rs1008375 1.000 rs1558378 chr4:17650351 T/C cg04450456 chr4:17643702 FAM184B 0.39 11.62 0.42 1.95e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs561341 0.783 rs512698 chr17:30292507 G/T cg23018236 chr17:30244563 NA -0.62 -10.04 -0.37 3.95e-22 Hip circumference adjusted for BMI; BRCA cis rs9788721 0.592 rs28564957 chr15:78906107 C/A cg24631222 chr15:78858424 CHRNA5 0.36 7.82 0.3 2.2e-14 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs9837602 0.592 rs629120 chr3:99425767 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.51 -9.46 -0.35 5.69e-20 Breast cancer; BRCA cis rs72781680 1.000 rs72798408 chr2:24181845 G/C cg08917208 chr2:24149416 ATAD2B 1.1 15.53 0.52 2.12e-46 Lymphocyte counts; BRCA cis rs35306767 0.903 rs11253492 chr10:936873 T/C cg20503657 chr10:835505 NA 1.04 18.27 0.59 2.66e-60 Eosinophil percentage of granulocytes; BRCA cis rs7618915 0.547 rs4687638 chr3:52651966 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.8 0.36 3.32e-21 Bipolar disorder; BRCA cis rs10089 1.000 rs10089 chr5:127522543 C/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.65 14.01 0.48 4.36e-39 Ileal carcinoids; BRCA cis rs34779708 0.801 rs12246600 chr10:35538121 A/C cg03585969 chr10:35415529 CREM 0.46 9.32 0.35 1.94e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg26513180 chr16:89883248 FANCA -0.59 -13.22 -0.46 1.87e-35 Vitiligo; BRCA cis rs7408868 1.000 rs2074618 chr19:15276143 C/T cg14696996 chr19:15285081 NOTCH3 0.98 14.37 0.49 8.85e-41 Pulse pressure; BRCA cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg24642439 chr20:33292090 TP53INP2 0.69 15.98 0.53 1.29e-48 Coronary artery disease; BRCA cis rs10504229 0.728 rs59266065 chr8:58156236 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs6500602 0.893 rs4786489 chr16:4485527 G/A cg08645402 chr16:4508243 NA 0.36 8.28 0.31 6.96e-16 Schizophrenia; BRCA trans rs629535 0.590 rs62513426 chr8:70136843 T/G cg21567404 chr3:27674614 NA -0.96 -17.52 -0.57 2.06e-56 Dupuytren's disease; BRCA cis rs739401 0.611 rs2301140 chr11:3022629 C/T cg05729581 chr11:3078854 CARS -0.34 -7.93 -0.3 9.96e-15 Longevity; BRCA cis rs6910061 1.000 rs6456868 chr6:11115183 G/A cg27233058 chr6:11094804 LOC221710 0.53 9.43 0.35 7.64e-20 Diabetic kidney disease; BRCA cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg05347473 chr6:146136440 FBXO30 0.59 11.32 0.41 3.19e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs4302748 0.862 rs35940984 chr7:36187333 C/G cg24442661 chr7:36192818 EEPD1 0.46 8.8 0.33 1.27e-17 Platelet count; BRCA cis rs11792861 0.926 rs72607174 chr9:111899132 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.04 0.3 4.26e-15 Menarche (age at onset); BRCA cis rs66530629 0.958 rs55965563 chr1:25050829 G/A cg01905478 chr1:25040257 NA 0.36 8.29 0.31 6.5e-16 Plateletcrit; BRCA cis rs9872999 1 rs9872999 chr3:133457514 C/T cg24879335 chr3:133465180 TF 0.33 11.07 0.4 3.57e-26 Iron status biomarkers; BRCA cis rs6723226 0.804 rs17428810 chr2:32736043 T/C cg02381751 chr2:32503542 YIPF4 -0.62 -12.32 -0.44 1.87e-31 Intelligence (multi-trait analysis); BRCA cis rs801193 1.000 rs7788576 chr7:66148302 G/A cg18876405 chr7:65276391 NA -0.63 -15.5 -0.52 3.05e-46 Aortic root size; BRCA cis rs595982 0.559 rs4802516 chr19:49366170 T/C cg21252483 chr19:49399788 TULP2 -0.4 -9.08 -0.34 1.39e-18 Red cell distribution width; BRCA cis rs11098499 0.955 rs1397608 chr4:120161744 A/G cg09307838 chr4:120376055 NA 0.61 12.31 0.44 2.09e-31 Corneal astigmatism; BRCA cis rs7727544 0.625 rs3864277 chr5:131420249 G/A cg14196790 chr5:131705035 SLC22A5 0.37 9.09 0.34 1.25e-18 Blood metabolite levels; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg08888203 chr3:10149979 C3orf24 0.61 13.03 0.46 1.34e-34 Alzheimer's disease; BRCA cis rs9811920 0.609 rs2452320 chr3:99645216 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 9.16e-53 Axial length; BRCA cis rs897984 0.609 rs17839567 chr16:31057945 A/G cg02466173 chr16:30829666 NA -0.41 -9.27 -0.34 2.86e-19 Dementia with Lewy bodies; BRCA cis rs6951245 0.572 rs79396675 chr7:1055047 C/T cg03188948 chr7:1209495 NA 0.78 8.05 0.3 3.95e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs473651 0.935 rs559579 chr2:239339501 G/C cg18131467 chr2:239335373 ASB1 0.86 21.85 0.65 1.88e-79 Multiple system atrophy; BRCA cis rs8114671 0.836 rs2425012 chr20:33581955 G/A cg07148914 chr20:33460835 GGT7 -0.43 -9.31 -0.35 2.09e-19 Height; BRCA cis rs12618769 0.597 rs17031139 chr2:99036530 A/G cg10123293 chr2:99228465 UNC50 -0.39 -7.97 -0.3 7.3e-15 Bipolar disorder; BRCA cis rs2153535 0.580 rs1115079 chr6:8449615 G/C cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs11098499 0.754 rs12711071 chr4:120240934 A/G cg09307838 chr4:120376055 NA 0.62 13.47 0.47 1.37e-36 Corneal astigmatism; BRCA cis rs875971 0.723 rs28391294 chr7:65654315 T/C cg11764359 chr7:65958608 NA -0.76 -17.43 -0.57 5.6e-56 Aortic root size; BRCA trans rs4650994 1.000 rs6660445 chr1:178528871 C/T cg05059571 chr16:84539110 KIAA1609 -0.41 -9.22 -0.34 4.12e-19 HDL cholesterol levels;HDL cholesterol; BRCA cis rs12711979 0.740 rs6711964 chr2:3820916 A/T cg17052675 chr2:3827356 NA -0.48 -14.31 -0.49 1.8e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs2836974 0.965 rs6517538 chr21:40656242 C/T cg11890956 chr21:40555474 PSMG1 1.04 29.28 0.76 3.45e-120 Cognitive function; BRCA trans rs11098499 0.863 rs11098532 chr4:120490726 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.37 8.43 0.32 2.23e-16 Corneal astigmatism; BRCA cis rs2645694 0.626 rs2703118 chr4:77823672 A/G cg10057126 chr4:77819792 ANKRD56 0.67 15.52 0.52 2.43e-46 Emphysema distribution in smoking; BRCA cis rs2652822 0.935 rs12148069 chr15:63443792 A/T cg02713581 chr15:63449717 RPS27L 0.49 9.87 0.36 1.71e-21 Metabolic traits; BRCA trans rs1005277 0.522 rs289650 chr10:37975505 G/T cg17830980 chr10:43048298 ZNF37B -0.37 -8.87 -0.33 7.12e-18 Extrinsic epigenetic age acceleration; BRCA cis rs9291683 0.552 rs10939656 chr4:10014646 A/C cg00071950 chr4:10020882 SLC2A9 0.64 16.26 0.54 5.02e-50 Bone mineral density; BRCA cis rs2985684 0.894 rs8005990 chr14:50022248 G/A cg04989706 chr14:50066350 PPIL5 -0.48 -9.32 -0.35 1.93e-19 Carotid intima media thickness; BRCA cis rs7811142 0.943 rs111493473 chr7:100049742 A/G cg00814883 chr7:100076585 TSC22D4 -0.52 -11.91 -0.43 1.13e-29 Platelet count; BRCA cis rs9291683 0.588 rs17247314 chr4:10004743 C/G cg11266682 chr4:10021025 SLC2A9 0.47 12.31 0.44 2.18e-31 Bone mineral density; BRCA cis rs780096 0.526 rs2010087 chr2:27637235 C/T cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.73 -0.33 2.24e-17 Total body bone mineral density; BRCA cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg11644478 chr21:40555479 PSMG1 0.73 14.23 0.49 4.27e-40 Cognitive function; BRCA cis rs4819052 0.788 rs35323494 chr21:46703739 G/A cg11663144 chr21:46675770 NA -0.39 -8.19 -0.31 1.41e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4481887 1.000 rs6659039 chr1:248465689 C/T cg13385794 chr1:248469461 NA 0.28 7.8 0.3 2.44e-14 Common traits (Other); BRCA cis rs9811920 0.609 rs7638900 chr3:99670773 T/C cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.31 0.31 5.91e-16 Axial length; BRCA cis rs7247513 1.000 rs2042947 chr19:12693103 A/G cg01871581 chr19:12707946 ZNF490 -0.71 -16.68 -0.55 4.23e-52 Bipolar disorder; BRCA cis rs6942756 0.531 rs9649530 chr7:128927406 G/A cg02491457 chr7:128862824 NA 0.45 9.42 0.35 8.13e-20 White matter hyperintensity burden; BRCA cis rs250677 0.522 rs10040798 chr5:148367324 A/G cg12140854 chr5:148520817 ABLIM3 0.41 8.26 0.31 8.63e-16 Breast cancer; BRCA cis rs67478160 0.643 rs6575997 chr14:104228546 C/T cg08213375 chr14:104286397 PPP1R13B -0.61 -16.79 -0.55 1.06e-52 Schizophrenia; BRCA cis rs736408 0.812 rs2270197 chr3:52824095 T/G cg18404041 chr3:52824283 ITIH1 -0.52 -15.44 -0.52 5.83e-46 Bipolar disorder; BRCA cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg02038168 chr22:39784481 NA -0.42 -8.66 -0.32 3.87e-17 Intelligence (multi-trait analysis); BRCA cis rs41005 1.000 rs193929 chr2:8107620 G/T cg03155496 chr2:8117019 LOC339788 0.57 15.65 0.53 5.6e-47 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg14829155 chr15:31115871 NA 0.55 13.76 0.48 6.77e-38 Huntington's disease progression; BRCA cis rs9814567 0.806 rs9841371 chr3:134320765 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1577917 0.958 rs3900313 chr6:86537154 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs10751667 0.643 rs10902257 chr11:973577 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.57 0.55 1.53e-51 Alzheimer's disease (late onset); BRCA trans rs1005277 0.540 rs4934907 chr10:38015230 A/C cg17830980 chr10:43048298 ZNF37B -0.41 -9.62 -0.36 1.48e-20 Extrinsic epigenetic age acceleration; BRCA trans rs7618501 1.000 rs57648519 chr3:49813169 C/A cg21582582 chr3:182698605 DCUN1D1 0.4 10.41 0.38 1.49e-23 Intelligence (multi-trait analysis); BRCA cis rs10883723 0.962 rs11191294 chr10:104225837 T/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 17.02 0.56 7.45e-54 Allergic disease (asthma, hay fever or eczema); BRCA cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.4 -9.65 -0.36 1.17e-20 Alzheimer's disease (late onset); BRCA cis rs999943 0.846 rs999942 chr6:33624902 G/C cg14003231 chr6:33640908 ITPR3 0.67 15.1 0.51 2.67e-44 Obesity (extreme); BRCA cis rs12497850 1.000 rs4858828 chr3:48724811 C/T cg06212747 chr3:49208901 KLHDC8B 0.45 9.37 0.35 1.28e-19 Parkinson's disease; BRCA trans rs11039798 0.588 rs11039807 chr11:48549391 T/A cg03929089 chr4:120376271 NA 0.47 7.93 0.3 1.01e-14 Axial length; BRCA cis rs2153535 0.563 rs1737585 chr6:8536594 A/G cg23788917 chr6:8435910 SLC35B3 -0.47 -10.34 -0.38 2.79e-23 Motion sickness; BRCA cis rs13095912 0.962 rs11916386 chr3:185308069 G/T cg11274856 chr3:185301563 NA 0.34 8.5 0.32 1.36e-16 Systolic blood pressure; BRCA trans rs3960554 0.808 rs2302434 chr7:75630183 C/T cg19862616 chr7:65841803 NCRNA00174 0.55 11.58 0.42 2.72e-28 Eotaxin levels; BRCA cis rs1707322 0.721 rs10789470 chr1:46158331 T/G cg06784218 chr1:46089804 CCDC17 0.51 12.14 0.43 1.14e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6430585 0.591 rs77096272 chr2:136663605 C/A cg07169764 chr2:136633963 MCM6 1.23 23.94 0.69 6.72e-91 Corneal structure; BRCA cis rs798554 0.796 rs2158694 chr7:2863443 T/G cg19346786 chr7:2764209 NA -0.32 -9.34 -0.35 1.55e-19 Height; BRCA cis rs17270561 0.609 rs1892254 chr6:25750530 T/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.76 0.33 1.79e-17 Iron status biomarkers; BRCA cis rs17345786 0.628 rs11718446 chr3:101552553 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 12.79 0.45 1.65e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs12545109 0.800 rs1371936 chr8:57422715 A/G cg09654669 chr8:57350985 NA -0.42 -8.07 -0.3 3.57e-15 Obesity-related traits; BRCA cis rs2742417 0.603 rs2742371 chr3:45782763 G/A cg04837898 chr3:45731254 SACM1L -0.38 -7.81 -0.3 2.31e-14 Response to anti-depressant treatment in major depressive disorder; BRCA trans rs41997 0.785 rs2110215 chr7:118071216 C/T cg06123940 chr18:29597493 RNF125 -0.5 -7.87 -0.3 1.55e-14 Response to platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs2576037 0.583 rs9916891 chr18:44493521 C/T cg15049968 chr18:44337910 ST8SIA5 -0.28 -7.99 -0.3 6.24e-15 Personality dimensions; BRCA cis rs936229 0.749 rs6495127 chr15:75194490 C/T cg10253484 chr15:75165896 SCAMP2 -0.59 -11.35 -0.41 2.41e-27 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6456156 0.586 rs2001115 chr6:167486218 A/C cg07741184 chr6:167504864 NA 0.33 9.88 0.36 1.64e-21 Primary biliary cholangitis; BRCA cis rs798554 0.524 rs2283784 chr7:2855337 T/C cg09658497 chr7:2847517 GNA12 -0.4 -8.55 -0.32 9e-17 Height; BRCA cis rs9814567 1.000 rs7432268 chr3:134242051 T/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.97 -0.3 7.52e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs71636778 0.543 rs75305560 chr1:27242521 T/G cg12203394 chr1:27248618 NUDC 0.6 9.46 0.35 5.7e-20 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA trans rs3733585 0.781 rs4292328 chr4:9970962 C/T cg26043149 chr18:55253948 FECH -0.4 -8.87 -0.33 7.43e-18 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12493885 0.818 rs1521324 chr3:153758863 G/T cg17054900 chr3:154042577 DHX36 -0.5 -8.55 -0.32 8.73e-17 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs769267 0.930 rs10414830 chr19:19562332 C/T cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 7.93 0.3 9.75e-15 Tonsillectomy; BRCA cis rs17253792 0.822 rs10139905 chr14:56170031 T/C cg01858014 chr14:56050164 KTN1 -0.59 -9.11 -0.34 1.05e-18 Putamen volume; BRCA cis rs877282 0.891 rs10904557 chr10:797490 C/T cg17470449 chr10:769945 NA -0.52 -9.11 -0.34 1.09e-18 Uric acid levels; BRCA cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.07 0.43 2.39e-30 Bipolar disorder; BRCA cis rs9393692 0.967 rs6456712 chr6:26302573 A/C cg05868516 chr6:26286170 HIST1H4H 0.42 8.65 0.32 4.09e-17 Educational attainment; BRCA cis rs7103648 0.630 rs7934481 chr11:47883337 C/T cg20307385 chr11:47447363 PSMC3 0.72 16.44 0.55 6.91e-51 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs12477438 0.798 rs13393860 chr2:99590397 C/T cg08885076 chr2:99613938 TSGA10 -0.6 -13.44 -0.47 1.91e-36 Chronic sinus infection; BRCA cis rs4665809 1.000 rs4665816 chr2:26305094 G/C cg08470875 chr2:26401718 FAM59B -0.51 -8.52 -0.32 1.15e-16 Gut microbiome composition (summer); BRCA cis rs13118159 0.801 rs7664474 chr4:1329116 T/A cg20887711 chr4:1340912 KIAA1530 0.4 9.69 0.36 7.97e-21 Longevity; BRCA cis rs1843834 0.858 rs2047136 chr2:225511361 A/T cg22455342 chr2:225449267 CUL3 0.41 9.75 0.36 4.83e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs6952808 0.689 rs2008263 chr7:2048335 A/G cg18279126 chr7:2041391 MAD1L1 0.39 9.01 0.34 2.45e-18 Bipolar disorder and schizophrenia; BRCA cis rs16854884 0.586 rs7650172 chr3:143729408 G/C cg06585982 chr3:143692056 C3orf58 0.5 10.63 0.39 2.09e-24 Economic and political preferences (feminism/equality); BRCA cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg00852783 chr1:26633632 UBXN11 0.51 11.01 0.4 6.2e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs6570726 0.738 rs6917199 chr6:145918320 G/A cg23711669 chr6:146136114 FBXO30 0.79 18.69 0.59 1.59e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs4911420 chr20:32998654 A/G cg24642439 chr20:33292090 TP53INP2 -0.54 -11.84 -0.42 2.17e-29 Glomerular filtration rate (creatinine); BRCA cis rs867371 0.964 rs7169961 chr15:82478929 C/T cg00614314 chr15:82944287 LOC80154 0.42 8.89 0.33 6.09e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs7246657 0.722 rs4802029 chr19:38055612 A/T cg18154014 chr19:37997991 ZNF793 0.48 9.13 0.34 8.69e-19 Coronary artery calcification; BRCA cis rs12887734 0.569 rs66953418 chr14:104271470 G/A cg01849466 chr14:104193079 ZFYVE21 -0.47 -10.58 -0.39 3.1e-24 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9790314 1.000 rs9870059 chr3:161017240 T/C cg03342759 chr3:160939853 NMD3 -0.64 -13.58 -0.47 4.34e-37 Morning vs. evening chronotype; BRCA cis rs7631605 0.905 rs9852378 chr3:37038771 C/T cg15934958 chr3:37212084 LRRFIP2 0.41 9.57 0.35 2.38e-20 Cerebrospinal P-tau181p levels; BRCA cis rs11190604 1.000 rs2495754 chr10:102324812 C/T cg07080220 chr10:102295463 HIF1AN 0.64 15.0 0.51 8.72e-44 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2370759 1.000 rs11594963 chr10:32625736 G/A cg01819863 chr10:32635814 EPC1 1.17 20.75 0.63 1.69e-73 Sexual dysfunction (female); BRCA cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg22601191 chr20:60968625 CABLES2 0.46 10.68 0.39 1.28e-24 Colorectal cancer; BRCA cis rs1003719 0.646 rs2835672 chr21:38581234 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.63 -14.51 -0.5 1.83e-41 Eye color traits; BRCA cis rs6570726 0.791 rs4335004 chr6:145904764 G/A cg05347473 chr6:146136440 FBXO30 0.42 8.34 0.31 4.69e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9682041 0.932 rs7631221 chr3:170069893 A/G cg11886554 chr3:170076028 SKIL 0.59 11.47 0.41 7.68e-28 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs60843830 0.662 rs6721594 chr2:305203 C/T cg25945732 chr2:264204 ACP1;SH3YL1 -0.61 -13.55 -0.47 5.7e-37 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7267979 1.000 rs7020 chr20:25278600 G/A cg08601574 chr20:25228251 PYGB 0.34 8.31 0.31 5.58e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs3733585 0.699 rs7437120 chr4:9967683 T/A cg00071950 chr4:10020882 SLC2A9 -0.44 -10.31 -0.38 3.83e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6424115 1.000 rs2256179 chr1:24132305 A/G cg10978503 chr1:24200527 CNR2 -0.44 -11.85 -0.42 1.99e-29 Immature fraction of reticulocytes; BRCA cis rs8031584 0.918 rs11639169 chr15:31255438 C/T cg14829155 chr15:31115871 NA -0.41 -9.17 -0.34 6.27e-19 Huntington's disease progression; BRCA trans rs57221529 0.825 rs7443550 chr5:578404 G/T cg08313168 chr12:7315531 NA 0.5 8.09 0.3 2.95e-15 Lung disease severity in cystic fibrosis; BRCA cis rs2762353 1.000 rs2762353 chr6:25794431 A/G cg03517284 chr6:25882590 NA -0.46 -10.44 -0.38 1.11e-23 Blood metabolite levels; BRCA cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs365132 0.875 rs353494 chr5:176431759 C/G cg16309518 chr5:176445507 NA -0.4 -9.72 -0.36 6.26e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs2204008 0.811 rs4882300 chr12:38415224 A/T cg13010199 chr12:38710504 ALG10B -0.37 -8.06 -0.3 3.69e-15 Bladder cancer; BRCA cis rs7666738 0.724 rs28451676 chr4:98966990 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.47e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6582630 0.519 rs11182457 chr12:38538331 G/A cg13010199 chr12:38710504 ALG10B 0.52 10.59 0.39 2.93e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs6005807 0.719 rs73430189 chr22:29004881 C/A cg12565055 chr22:29076175 TTC28 0.48 8.79 0.33 1.41e-17 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs6952808 1.000 rs6952808 chr7:1886535 C/G cg03354898 chr7:1950403 MAD1L1 -0.38 -7.91 -0.3 1.14e-14 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.601 rs6906170 chr6:8543128 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.15e-23 Motion sickness; BRCA cis rs9811920 0.638 rs793461 chr3:99615758 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs8114671 0.527 rs6060068 chr20:33415820 T/A cg24642439 chr20:33292090 TP53INP2 0.42 8.81 0.33 1.19e-17 Height; BRCA cis rs9814567 0.929 rs9815297 chr3:134215052 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.57 -0.61 3.58e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7246657 0.525 rs10405238 chr19:37488055 T/G cg23950597 chr19:37808831 NA -0.6 -9.37 -0.35 1.21e-19 Coronary artery calcification; BRCA cis rs7772486 0.701 rs7772717 chr6:145954854 T/C cg23711669 chr6:146136114 FBXO30 0.79 19.0 0.6 3.6e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs514406 0.858 rs574853 chr1:53310959 A/T cg27535305 chr1:53392650 SCP2 -0.37 -9.32 -0.35 1.84e-19 Monocyte count; BRCA cis rs2836974 0.799 rs13047550 chr21:40515495 T/C cg17971929 chr21:40555470 PSMG1 0.7 14.66 0.5 3.71e-42 Cognitive function; BRCA cis rs1005277 0.522 rs200943 chr10:38148730 A/G cg00409905 chr10:38381863 ZNF37A -0.49 -10.48 -0.38 7.75e-24 Extrinsic epigenetic age acceleration; BRCA cis rs17253792 0.822 rs80085988 chr14:56096173 A/G cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.13e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7589728 0.563 rs78168096 chr2:88473575 G/A cg24977027 chr2:88469347 THNSL2 0.56 9.38 0.35 1.12e-19 Plasma clusterin levels; BRCA trans rs1997103 1.000 rs10278894 chr7:55404748 A/G cg20935933 chr6:143382018 AIG1 0.6 11.63 0.42 1.73e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9611565 0.512 rs139572 chr22:42214532 C/T cg03806693 chr22:41940476 POLR3H -0.95 -13.81 -0.48 3.68e-38 Vitiligo; BRCA cis rs2576037 0.583 rs593340 chr18:44418346 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.1 0.49 1.66e-39 Personality dimensions; BRCA cis rs739401 0.572 rs739400 chr11:3016520 G/A cg05729581 chr11:3078854 CARS -0.33 -8.28 -0.31 7.23e-16 Longevity; BRCA cis rs7666738 0.680 rs11726233 chr4:99079773 G/A cg05340658 chr4:99064831 C4orf37 0.66 15.53 0.52 2.29e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs115279324 chr4:99042114 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.64 0.55 6.71e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs2882667 0.898 rs10038121 chr5:138389602 A/G cg04439458 chr5:138467593 SIL1 -0.33 -8.97 -0.33 3.32e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9393692 0.905 rs2393592 chr6:26285560 A/G cg00631329 chr6:26305371 NA -0.42 -12.56 -0.44 1.73e-32 Educational attainment; BRCA cis rs6951245 0.935 rs61910751 chr7:1097895 A/G cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg27624424 chr6:160112604 SOD2 0.41 8.02 0.3 5.06e-15 Age-related macular degeneration (geographic atrophy); BRCA cis rs3820928 0.874 rs4423583 chr2:227874957 A/G cg11843606 chr2:227700838 RHBDD1 0.37 8.06 0.3 3.67e-15 Pulmonary function; BRCA cis rs2304069 0.954 rs6579767 chr5:149406271 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.83 16.78 0.55 1.21e-52 HIV-1 control; BRCA cis rs4808199 0.895 rs4808196 chr19:19476520 G/A cg03709012 chr19:19516395 GATAD2A 1.08 19.97 0.62 2.68e-69 Nonalcoholic fatty liver disease; BRCA cis rs10911232 0.507 rs4483371 chr1:182988352 G/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.19e-52 Hypertriglyceridemia; BRCA cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg20203395 chr5:56204925 C5orf35 0.41 9.17 0.34 6.43e-19 Initial pursuit acceleration; BRCA cis rs7249142 0.597 rs7250650 chr19:19285989 A/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.39 -0.32 3.03e-16 IgG glycosylation; BRCA cis rs2463822 1.000 rs2463821 chr11:62111662 T/C cg06239285 chr11:62104954 ASRGL1 0.63 9.02 0.34 2.14e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg21143896 chr7:2802374 GNA12 -0.38 -9.28 -0.34 2.65e-19 Height; BRCA cis rs2882667 0.587 rs6596450 chr5:138146520 G/A cg04439458 chr5:138467593 SIL1 0.31 7.83 0.3 2.03e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs11098499 0.863 rs6835635 chr4:120458867 A/G cg09307838 chr4:120376055 NA 0.68 13.45 0.47 1.81e-36 Corneal astigmatism; BRCA cis rs2617583 0.935 rs1354139 chr5:1451782 T/C cg07151155 chr5:1473589 LPCAT1 -0.39 -8.55 -0.32 8.8e-17 Breast cancer; BRCA cis rs9311474 0.607 rs4234633 chr3:52557038 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 10.05 0.37 3.54e-22 Electroencephalogram traits; BRCA cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg00106254 chr7:1943704 MAD1L1 -0.3 -8.15 -0.31 1.87e-15 Bipolar disorder and schizophrenia; BRCA cis rs72781680 0.898 rs56216411 chr2:23934533 G/A cg08917208 chr2:24149416 ATAD2B 1.05 14.21 0.49 5.26e-40 Lymphocyte counts; BRCA cis rs698813 0.543 rs12468824 chr2:44482448 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.54 0.32 9.69e-17 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs941873 0.772 rs1316312 chr10:81110417 G/C cg08514558 chr10:81106712 PPIF 0.38 8.73 0.33 2.3e-17 Height; BRCA cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg14983838 chr19:29218262 NA 0.55 10.78 0.39 5.09e-25 Methadone dose in opioid dependence; BRCA trans rs35110281 0.807 rs9976441 chr21:45046591 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.4 8.49 0.32 1.4e-16 Mean corpuscular volume; BRCA cis rs7254114 0.578 rs7246614 chr19:11310538 C/T cg06870470 chr19:11315767 DOCK6 -0.36 -8.16 -0.31 1.74e-15 Immature fraction of reticulocytes; BRCA cis rs1865760 0.613 rs2071300 chr6:25914572 C/T cg03264133 chr6:25882463 NA -0.4 -9.22 -0.34 4.39e-19 Height; BRCA cis rs4481887 1.000 rs10888352 chr1:248451965 G/A cg00666640 chr1:248458726 OR2T12 0.35 8.94 0.33 4.31e-18 Common traits (Other); BRCA cis rs965469 0.779 rs6037546 chr20:3298697 G/T cg25506879 chr20:3388711 C20orf194 -0.43 -8.73 -0.33 2.23e-17 IFN-related cytopenia; BRCA cis rs1448094 0.549 rs7297996 chr12:86235899 C/T cg02569458 chr12:86230093 RASSF9 0.32 8.01 0.3 5.6e-15 Major depressive disorder; BRCA cis rs7520050 0.966 rs11211199 chr1:46287869 T/C cg24296786 chr1:45957014 TESK2 0.44 10.03 0.37 4.21e-22 Red blood cell count;Reticulocyte count; BRCA cis rs710865 0.519 rs10753518 chr1:19483593 T/C cg13387374 chr1:19411106 UBR4 0.43 9.62 0.36 1.45e-20 Brain structure; BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.55 9.15 0.34 7.53e-19 Renal function-related traits (BUN); BRCA cis rs12540874 0.670 rs3887826 chr7:50544961 G/A cg18232548 chr7:50535776 DDC -0.55 -13.75 -0.48 7.53e-38 Systemic sclerosis; BRCA cis rs1882538 0.538 rs9649587 chr7:133104569 A/C cg10665199 chr7:133106180 EXOC4 0.46 10.03 0.37 4.48e-22 Intelligence (multi-trait analysis); BRCA cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.8 21.77 0.65 5.24e-79 Chronic sinus infection; BRCA cis rs9790314 0.690 rs1599389 chr3:160836006 G/A cg03342759 chr3:160939853 NMD3 -0.54 -11.39 -0.41 1.79e-27 Morning vs. evening chronotype; BRCA trans rs1733410 0.504 rs11181874 chr12:37912890 C/A cg06521331 chr12:34319734 NA 0.46 8.91 0.33 5.31e-18 Morning vs. evening chronotype; BRCA cis rs12545109 0.800 rs2118260 chr8:57393481 T/C cg09654669 chr8:57350985 NA -0.42 -8.03 -0.3 4.6e-15 Obesity-related traits; BRCA cis rs9300255 0.544 rs1727309 chr12:123658258 A/G cg00376283 chr12:123451042 ABCB9 0.51 9.89 0.36 1.47e-21 Neutrophil percentage of white cells; BRCA cis rs2070488 1.000 rs7433707 chr3:38443180 G/C cg24069376 chr3:38537580 EXOG 0.4 11.35 0.41 2.4200000000000002e-27 Electrocardiographic conduction measures; BRCA cis rs2070488 0.775 rs4371464 chr3:38548021 T/C cg24069376 chr3:38537580 EXOG -0.32 -9.07 -0.34 1.47e-18 Electrocardiographic conduction measures; BRCA cis rs758324 0.947 rs7708140 chr5:131252396 A/G cg06307176 chr5:131281290 NA 0.55 11.72 0.42 7.37e-29 Alzheimer's disease in APOE e4- carriers; BRCA cis rs7917772 0.503 rs2031602 chr10:104307955 G/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.21 0.62 1.36e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs523522 0.962 rs10849759 chr12:120994488 T/A cg12219531 chr12:120966889 COQ5 0.54 11.37 0.41 2.11e-27 High light scatter reticulocyte count; BRCA cis rs3733585 0.699 rs1079128 chr4:9951221 T/C cg11266682 chr4:10021025 SLC2A9 -0.41 -10.75 -0.39 7.02e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.08 19.57 0.61 3.74e-67 Platelet count; BRCA cis rs3784262 0.967 rs35511675 chr15:58266978 T/A cg12031962 chr15:58353849 ALDH1A2 -0.49 -13.02 -0.46 1.57e-34 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7772486 0.754 rs4896838 chr6:146015451 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.46 -0.32 1.84e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs12681288 0.523 rs73176528 chr8:961962 G/A cg04851639 chr8:1020857 NA -0.32 -8.82 -0.33 1.05e-17 Schizophrenia; BRCA cis rs3733585 0.673 rs6840802 chr4:9965633 C/G cg00071950 chr4:10020882 SLC2A9 0.43 9.84 0.36 2.35e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6429082 0.608 rs4659836 chr1:235564412 G/A cg26050004 chr1:235667680 B3GALNT2 -0.52 -12.2 -0.43 6.42e-31 Adiposity; BRCA cis rs6424115 0.800 rs4649123 chr1:24197696 A/G cg10978503 chr1:24200527 CNR2 0.52 13.84 0.48 2.7e-38 Immature fraction of reticulocytes; BRCA cis rs2153535 0.580 rs1119688 chr6:8460850 T/C cg07606381 chr6:8435919 SLC35B3 0.66 14.46 0.5 3.22e-41 Motion sickness; BRCA cis rs1048238 0.506 rs7547314 chr1:16186722 G/A cg16109817 chr1:16162209 FLJ37453 -0.29 -8.24 -0.31 1.01e-15 Systolic blood pressure; BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg23358479 chr7:1110784 C7orf50 -0.48 -8.17 -0.31 1.68e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2625529 0.642 rs2200056 chr15:72302667 T/C cg16672083 chr15:72433130 SENP8 -0.87 -18.02 -0.58 5.19e-59 Red blood cell count; BRCA cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs3771570 0.901 rs55811034 chr2:242406245 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.44 0.35 7.03e-20 Prostate cancer; BRCA cis rs941873 0.836 rs6480931 chr10:81108482 T/C cg11057378 chr10:81107060 PPIF 0.41 9.53 0.35 3.23e-20 Height; BRCA cis rs7572263 0.724 rs35551278 chr2:209056128 A/G cg23998903 chr2:209048830 C2orf80 -0.42 -8.5 -0.32 1.3e-16 Glioma;Non-glioblastoma glioma; BRCA cis rs2075371 0.764 rs1643034 chr7:134006176 A/G cg20476274 chr7:133979776 SLC35B4 0.66 19.06 0.6 1.83e-64 Mean platelet volume; BRCA cis rs11190604 0.945 rs7091356 chr10:102292268 G/C cg07080220 chr10:102295463 HIF1AN 0.63 14.54 0.5 1.32e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2882667 0.652 rs6596463 chr5:138444926 A/G cg04439458 chr5:138467593 SIL1 -0.36 -10.01 -0.37 5.19e-22 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9733 0.596 rs6685702 chr1:150656307 A/G cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg03709012 chr19:19516395 GATAD2A 0.81 18.82 0.6 3.53e-63 Tonsillectomy; BRCA cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.78 0.36 3.87e-21 Menopause (age at onset); BRCA cis rs4409675 0.576 rs7536088 chr1:28234325 A/G cg23691781 chr1:28212827 C1orf38 0.3 9.08 0.34 1.33e-18 Corneal astigmatism; BRCA cis rs12478296 1.000 rs57603292 chr2:243028537 G/A cg18898632 chr2:242989856 NA -0.5 -8.35 -0.31 4.1e-16 Obesity-related traits; BRCA cis rs4911259 0.552 rs13042651 chr20:31467423 C/T cg13636640 chr20:31349939 DNMT3B -0.45 -11.86 -0.42 1.78e-29 Inflammatory bowel disease; BRCA cis rs60871478 0.578 rs62432900 chr7:826794 G/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.57 8.41 0.32 2.78e-16 Cerebrospinal P-tau181p levels; BRCA cis rs2404602 0.684 rs1011083 chr15:77007527 C/T cg23625390 chr15:77176239 SCAPER -0.57 -14.8 -0.51 7.8e-43 Blood metabolite levels; BRCA cis rs9359856 0.510 rs74437492 chr6:90338728 A/G cg13799429 chr6:90582589 CASP8AP2 -0.72 -10.84 -0.39 2.89e-25 Bipolar disorder; BRCA cis rs10411936 0.692 rs3810196 chr19:16601154 T/C cg10248733 chr19:16607483 C19orf44;CALR3 0.45 9.59 0.35 1.9e-20 White blood cell count;Multiple sclerosis; BRCA cis rs17401966 0.838 rs35759975 chr1:10474430 A/T cg03954927 chr1:10346856 KIF1B 0.43 13.27 0.46 1.12e-35 Hepatocellular carcinoma; BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg25036284 chr2:26402008 FAM59B -0.78 -11.85 -0.42 2.08e-29 Gut microbiome composition (summer); BRCA cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg04455712 chr21:45112962 RRP1B 0.35 8.84 0.33 8.98e-18 Mean corpuscular volume; BRCA cis rs965469 1.000 rs6051672 chr20:3224819 C/T cg25506879 chr20:3388711 C20orf194 -0.54 -10.27 -0.38 5.37e-23 IFN-related cytopenia; BRCA trans rs79911532 0.515 rs115332207 chr7:75635405 G/A cg19862616 chr7:65841803 NCRNA00174 0.64 9.15 0.34 7.7e-19 Mononucleosis; BRCA cis rs875971 0.830 rs12673450 chr7:66009220 G/A cg11764359 chr7:65958608 NA 0.75 16.17 0.54 1.47e-49 Aortic root size; BRCA cis rs2835872 0.733 rs1787400 chr21:39038217 G/C cg06728970 chr21:39037746 KCNJ6 0.45 12.72 0.45 3.39e-33 Electroencephalographic traits in alcoholism; BRCA cis rs4919087 0.962 rs10786324 chr10:99054387 A/G cg25902810 chr10:99078978 FRAT1 0.45 9.48 0.35 4.99e-20 Monocyte count; BRCA cis rs7903847 0.642 rs10882926 chr10:99160690 C/T cg08345082 chr10:99160200 RRP12 0.29 8.52 0.32 1.14e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs17092148 0.887 rs2378199 chr20:33186480 T/C cg16810054 chr20:33298113 TP53INP2 -0.47 -10.76 -0.39 6.22e-25 Neuroticism; BRCA cis rs12545109 0.879 rs2576580 chr8:57365828 G/C cg09654669 chr8:57350985 NA -0.46 -8.66 -0.32 3.82e-17 Obesity-related traits; BRCA cis rs7917772 0.510 rs2001389 chr10:104375258 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.47 14.29 0.49 2.11e-40 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11785693 0.862 rs17435835 chr8:5000713 C/T cg26367366 chr8:4980734 NA -0.66 -11.75 -0.42 5.29e-29 Neuroticism (multi-trait analysis);Neuroticism; BRCA trans rs11098499 0.863 rs6835635 chr4:120458867 A/G cg25214090 chr10:38739885 LOC399744 0.57 12.38 0.44 1.06e-31 Corneal astigmatism; BRCA cis rs12995491 0.731 rs17435433 chr2:88509616 A/G cg04511125 chr2:88470314 THNSL2 -0.53 -10.92 -0.4 1.37e-25 Response to metformin (IC50); BRCA cis rs17376456 0.877 rs10060160 chr5:93387879 G/A cg21475434 chr5:93447410 FAM172A 0.69 8.62 0.32 5.3e-17 Diabetic retinopathy; BRCA trans rs9858542 1.000 rs11130213 chr3:49712297 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.6 -0.36 1.78e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1865760 0.964 rs1324084 chr6:25915134 C/T cg16482183 chr6:26056742 HIST1H1C 0.55 11.32 0.41 3.23e-27 Height; BRCA cis rs875971 1.000 rs10244498 chr7:66116056 A/G cg18876405 chr7:65276391 NA 0.54 12.47 0.44 4.31e-32 Aortic root size; BRCA cis rs7264396 0.563 rs2425131 chr20:34337074 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -11.91 -0.43 1.13e-29 Total cholesterol levels; BRCA cis rs9309473 1.000 rs6710438 chr2:73820108 C/G cg20560298 chr2:73613845 ALMS1 0.4 9.73 0.36 6e-21 Metabolite levels; BRCA cis rs4665809 1.000 rs10048683 chr2:26320519 C/T cg25036284 chr2:26402008 FAM59B -0.64 -10.47 -0.38 8.65e-24 Gut microbiome composition (summer); BRCA cis rs1971762 0.563 rs10747679 chr12:54077750 C/T cg23533419 chr12:54090519 NA -0.33 -8.37 -0.31 3.69e-16 Height; BRCA cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg20887711 chr4:1340912 KIAA1530 0.38 8.85 0.33 8.47e-18 Longevity; BRCA cis rs73001065 0.892 rs58542926 chr19:19379549 C/T cg03709012 chr19:19516395 GATAD2A 0.81 7.94 0.3 8.96e-15 LDL cholesterol; BRCA trans rs35110281 0.807 rs2838325 chr21:45014284 A/T cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.37 -8.11 -0.31 2.62e-15 Mean corpuscular volume; BRCA cis rs2836974 0.666 rs11910705 chr21:40685604 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -14.24 -0.49 3.69e-40 Cognitive function; BRCA cis rs9443189 0.570 rs529383 chr6:76297847 T/G cg01950844 chr6:76311363 SENP6 0.74 10.02 0.37 4.85e-22 Prostate cancer; BRCA trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.03 -0.56 6.83e-54 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs114486414 chr8:58185103 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs634534 0.622 rs624273 chr11:65712413 A/G cg02427764 chr11:65769310 BANF1;EIF1AD 0.46 9.73 0.36 5.96e-21 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs10791323 0.538 rs1105494 chr11:133698733 A/C cg14349672 chr11:133703707 NA 0.4 8.68 0.32 3.26e-17 Childhood ear infection; BRCA cis rs9287719 0.870 rs728135 chr2:10745132 A/C cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs1707322 1.000 rs12060274 chr1:46291062 G/T cg06784218 chr1:46089804 CCDC17 0.45 10.81 0.39 3.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10751667 0.560 rs10902265 chr11:1003642 G/A cg06064525 chr11:970664 AP2A2 -0.31 -9.0 -0.34 2.54e-18 Alzheimer's disease (late onset); BRCA cis rs7647973 1.000 rs1009051 chr3:49521549 G/A cg07636037 chr3:49044803 WDR6 0.75 16.49 0.55 3.8e-51 Menarche (age at onset); BRCA cis rs12791968 0.765 rs12226848 chr11:45009204 C/T cg11846598 chr11:44996168 LOC221122 -0.46 -8.34 -0.31 4.42e-16 Inhibitory control; BRCA cis rs4434138 0.568 rs6414569 chr3:52708075 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.51 0.44 2.74e-32 Intelligence (multi-trait analysis); BRCA cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg08000102 chr2:233561755 GIGYF2 0.62 13.46 0.47 1.49e-36 Coronary artery disease; BRCA cis rs1691799 0.867 rs1027401 chr12:66760892 C/G cg16791601 chr12:66731901 HELB -0.65 -17.38 -0.57 1.03e-55 White blood cell count (basophil); BRCA cis rs2153535 0.580 rs6597322 chr6:8449952 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs12477438 0.798 rs6740035 chr2:99576578 C/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.64 -0.5 4.62e-42 Chronic sinus infection; BRCA trans rs9858542 0.953 rs35261698 chr3:49537839 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.48 -0.35 4.76e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs72781680 0.752 rs72796130 chr2:23919740 T/C cg08917208 chr2:24149416 ATAD2B 1.03 13.88 0.48 1.83e-38 Lymphocyte counts; BRCA cis rs1577917 1.000 rs7766645 chr6:86622238 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -11.28 -0.41 5.11e-27 Response to antipsychotic treatment; BRCA cis rs2011503 0.941 rs55822665 chr19:19383298 C/T cg11584989 chr19:19387371 SF4 0.6 13.54 0.47 6.49e-37 Bipolar disorder; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg02951883 chr7:2050386 MAD1L1 0.58 15.2 0.52 9.01e-45 Bipolar disorder and schizophrenia; BRCA cis rs6951245 1.000 rs79765398 chr7:1073764 A/G cg21664854 chr7:1097933 C7orf50;GPR146 0.61 11.68 0.42 1.03e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9399137 0.507 rs6923512 chr6:135335268 A/G cg24558204 chr6:135376177 HBS1L -0.6 -16.41 -0.54 9.53e-51 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1129187 0.935 rs9986447 chr6:42942779 C/T cg16590910 chr6:42928470 GNMT -0.41 -8.86 -0.33 7.79e-18 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1005277 0.522 rs1208767 chr10:38042295 G/T cg00409905 chr10:38381863 ZNF37A -0.48 -10.16 -0.37 1.4e-22 Extrinsic epigenetic age acceleration; BRCA cis rs763121 0.853 rs9306329 chr22:39072454 C/T cg06022373 chr22:39101656 GTPBP1 0.73 18.11 0.58 1.89e-59 Menopause (age at onset); BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg00106254 chr7:1943704 MAD1L1 -0.32 -7.92 -0.3 1.03e-14 Bipolar disorder and schizophrenia; BRCA cis rs1451375 0.572 rs896309 chr7:50545022 A/G cg18232548 chr7:50535776 DDC -0.42 -8.94 -0.33 4.2e-18 Malaria; BRCA cis rs2832191 0.791 rs2251517 chr21:30531951 T/G cg24692254 chr21:30365293 RNF160 0.69 18.42 0.59 4.02e-61 Dental caries; BRCA cis rs10504229 0.683 rs56408763 chr8:58137276 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg22907277 chr7:1156413 C7orf50 0.46 10.3 0.38 3.93e-23 Longevity;Endometriosis; BRCA cis rs6973256 0.897 rs1014442 chr7:133349281 A/T cg07491979 chr7:133331646 EXOC4 -0.39 -9.0 -0.34 2.5e-18 Intelligence (multi-trait analysis); BRCA cis rs13046373 0.535 rs35909098 chr21:32021649 C/T cg06468780 chr21:31798236 KRTAP13-3 0.34 8.39 0.31 3.16e-16 HDL cholesterol; BRCA cis rs1475911 0.708 rs56109792 chr21:43520060 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.85 17.74 0.57 1.51e-57 IgG glycosylation; BRCA cis rs10751667 0.666 rs10902241 chr11:949129 G/A cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.55 11.64 0.42 1.61e-28 Age-related macular degeneration (geographic atrophy); BRCA cis rs6500602 0.927 rs7200817 chr16:4480598 G/C cg08645402 chr16:4508243 NA 0.37 8.91 0.33 5.42e-18 Schizophrenia; BRCA cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs6840360 0.571 rs10007653 chr4:152524055 A/G cg22705602 chr4:152727874 NA -0.33 -8.43 -0.32 2.35e-16 Intelligence (multi-trait analysis); BRCA cis rs2882667 0.654 rs2351247 chr5:138185145 A/G cg04439458 chr5:138467593 SIL1 0.33 8.26 0.31 8.09e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs367943 1.000 rs460079 chr5:112800525 G/A cg12552261 chr5:112820674 MCC -0.55 -11.72 -0.42 6.92e-29 Type 2 diabetes; BRCA cis rs2836974 0.899 rs34978594 chr21:40580003 C/T cg17971929 chr21:40555470 PSMG1 0.8 18.66 0.59 2.21e-62 Cognitive function; BRCA cis rs9682041 0.627 rs10936625 chr3:170094908 G/T cg11886554 chr3:170076028 SKIL -0.48 -10.16 -0.37 1.35e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA trans rs9784649 0.641 rs72755823 chr5:25075537 T/C cg11038491 chr20:34638489 LOC647979 -0.57 -10.22 -0.37 8.48e-23 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9325144 0.555 rs1825806 chr12:38692547 G/A cg13010199 chr12:38710504 ALG10B 0.35 8.22 0.31 1.12e-15 Morning vs. evening chronotype; BRCA cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg23711669 chr6:146136114 FBXO30 0.81 19.41 0.61 2.43e-66 Lobe attachment (rater-scored or self-reported); BRCA cis rs6089829 0.962 rs6122347 chr20:61661866 C/T cg08045932 chr20:61659980 NA 0.5 11.43 0.41 1.2100000000000001e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg22800045 chr5:56110881 MAP3K1 -0.42 -8.32 -0.31 5.35e-16 Initial pursuit acceleration; BRCA cis rs9649213 0.574 rs62479853 chr7:97917158 G/T cg24562669 chr7:97807699 LMTK2 0.47 12.62 0.45 8.93e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs7572733 0.515 rs1836234 chr2:198882873 T/G cg00792783 chr2:198669748 PLCL1 0.38 8.74 0.33 2.06e-17 Dermatomyositis; BRCA cis rs4665809 0.590 rs4665313 chr2:26415897 A/G cg08470875 chr2:26401718 FAM59B -0.73 -11.73 -0.42 6.39e-29 Gut microbiome composition (summer); BRCA cis rs1707322 0.752 rs11211147 chr1:46110094 A/G cg06784218 chr1:46089804 CCDC17 0.5 12.18 0.43 7.68e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6461049 0.765 rs4719432 chr7:2140330 A/G cg21782813 chr7:2030301 MAD1L1 0.32 8.87 0.33 7.26e-18 Schizophrenia; BRCA cis rs2075371 0.966 rs2244690 chr7:133987039 A/G cg02659138 chr7:134003124 SLC35B4 0.34 10.72 0.39 9.27e-25 Mean platelet volume; BRCA cis rs524281 0.814 rs10896093 chr11:65958411 C/G cg16950941 chr11:66035639 RAB1B -0.37 -7.84 -0.3 1.93e-14 Electroencephalogram traits; BRCA cis rs724568 0.546 rs737359 chr2:67950714 A/G cg17945962 chr2:67939740 NA 0.38 9.99 0.37 6.38e-22 Major depressive disorder (broad); BRCA cis rs7572733 0.555 rs2164071 chr2:198915467 T/C cg00792783 chr2:198669748 PLCL1 0.39 8.75 0.33 1.95e-17 Dermatomyositis; BRCA cis rs637571 0.726 rs526631 chr11:65681965 T/G cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -9.05 -0.34 1.75e-18 Eosinophil percentage of white cells; BRCA cis rs2580764 0.516 rs2860453 chr2:55270485 T/G cg09592903 chr2:55203963 RTN4 0.38 9.7 0.36 7.68e-21 Mean platelet volume; BRCA cis rs881375 0.967 rs7864019 chr9:123692868 A/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.66 0.32 3.82e-17 Rheumatoid arthritis; BRCA cis rs6088580 0.634 rs6087588 chr20:33066369 T/C cg06115741 chr20:33292138 TP53INP2 0.36 8.01 0.3 5.64e-15 Glomerular filtration rate (creatinine); BRCA cis rs9400271 0.527 rs4945829 chr6:109638828 T/C cg01475377 chr6:109611718 NA 0.37 8.22 0.31 1.16e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24110177 chr3:50126178 RBM5 0.41 11.34 0.41 2.87e-27 Intelligence (multi-trait analysis); BRCA cis rs10927875 0.894 rs34957618 chr1:16320499 G/C cg21385522 chr1:16154831 NA -0.52 -10.22 -0.37 8.51e-23 Dilated cardiomyopathy; BRCA cis rs6942756 1.000 rs12112374 chr7:128950071 A/G cg02491457 chr7:128862824 NA -0.7 -13.76 -0.48 6.11e-38 White matter hyperintensity burden; BRCA cis rs3820928 0.605 rs6748311 chr2:227792530 T/A cg11843606 chr2:227700838 RHBDD1 -0.5 -11.45 -0.41 9.67e-28 Pulmonary function; BRCA cis rs12541635 0.934 rs62527361 chr8:107021574 T/A cg10147462 chr8:107024639 NA 0.35 9.47 0.35 5.49e-20 Age of smoking initiation; BRCA cis rs1707322 1.000 rs6672115 chr1:46272879 T/C cg06784218 chr1:46089804 CCDC17 0.5 11.82 0.42 2.71e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9467773 1.000 rs1321480 chr6:26532742 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.42 0.59 4.47e-61 Intelligence (multi-trait analysis); BRCA cis rs9815354 0.767 rs73830585 chr3:42003698 T/A cg03022575 chr3:42003672 ULK4 0.74 10.27 0.38 5.43e-23 Pulse pressure;Diastolic blood pressure; BRCA cis rs6542838 0.611 rs17758170 chr2:99531842 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.0 -0.34 2.54e-18 Fear of minor pain; BRCA cis rs13191362 0.810 rs34714603 chr6:163008078 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.48 8.75 0.33 1.9e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2387326 0.671 rs12268728 chr10:129945897 G/A cg16087940 chr10:129947807 NA -0.46 -8.23 -0.31 1.05e-15 Select biomarker traits; BRCA trans rs9291683 0.597 rs11723016 chr4:10126189 A/G cg26043149 chr18:55253948 FECH -0.4 -8.99 -0.34 2.68e-18 Bone mineral density; BRCA trans rs7618501 0.633 rs2008877 chr3:50162291 T/G cg21659725 chr3:3221576 CRBN -0.48 -12.25 -0.44 3.94e-31 Intelligence (multi-trait analysis); BRCA cis rs9814567 0.806 rs7648616 chr3:134318074 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4908768 0.539 rs922366 chr1:8653733 C/A cg20416874 chr1:8611966 RERE -0.29 -8.11 -0.31 2.6e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs10504229 0.728 rs17215621 chr8:58152706 C/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs701145 0.585 rs921318 chr3:153856775 T/G cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs7246657 0.722 rs1564206 chr19:38040076 C/T cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.57e-17 Coronary artery calcification; BRCA cis rs9443645 0.835 rs1044309 chr6:79646575 A/G cg09184832 chr6:79620586 NA -0.5 -11.06 -0.4 4.05e-26 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.943 rs73403312 chr7:100024153 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.57 9.14 0.34 7.92e-19 Platelet count; BRCA trans rs7248779 0.512 rs7250002 chr19:2413188 A/G cg25835954 chr13:50160062 RCBTB1 0.45 8.77 0.33 1.65e-17 Cortisol levels (saliva); BRCA cis rs7072216 0.806 rs9804285 chr10:100169472 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.72 -0.36 6.22e-21 Metabolite levels; BRCA cis rs17401966 0.522 rs17396973 chr1:10334924 C/T cg03954927 chr1:10346856 KIF1B 0.34 10.39 0.38 1.81e-23 Hepatocellular carcinoma; BRCA cis rs6547741 0.844 rs7586655 chr2:27915659 A/G cg27432699 chr2:27873401 GPN1 -0.52 -10.89 -0.4 1.82e-25 Oral cavity cancer; BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.62 10.08 0.37 2.94e-22 Renal function-related traits (BUN); BRCA cis rs9462846 1.000 rs9471950 chr6:42869040 G/A cg02353165 chr6:42928485 GNMT 0.49 8.67 0.32 3.44e-17 Blood protein levels; BRCA cis rs12050794 0.671 rs8192362 chr15:72519858 G/A cg16672083 chr15:72433130 SENP8 0.63 14.89 0.51 3.03e-43 Metabolite levels (HVA/MHPG ratio); BRCA cis rs7772486 0.875 rs1331637 chr6:146337087 T/C cg13319975 chr6:146136371 FBXO30 -0.36 -8.3 -0.31 6.2e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.756 rs9292125 chr5:56107200 C/T cg22800045 chr5:56110881 MAP3K1 0.64 12.31 0.44 2.05e-31 Initial pursuit acceleration; BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.89 0.36 1.49e-21 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs6532721 chr4:99048015 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg00814883 chr7:100076585 TSC22D4 -0.47 -10.54 -0.38 4.62e-24 Platelet count; BRCA cis rs780096 0.526 rs3845687 chr2:27689899 T/C cg21248554 chr2:27665150 KRTCAP3 -0.33 -8.65 -0.32 4.03e-17 Total body bone mineral density; BRCA cis rs2336384 1.000 rs4846083 chr1:12045555 G/T cg13216073 chr1:12042593 MFN2 0.45 9.81 0.36 3.05e-21 Platelet count; BRCA cis rs1843834 0.929 rs4674934 chr2:225516468 A/T cg22455342 chr2:225449267 CUL3 -0.34 -8.54 -0.32 1e-16 IgE levels in asthmatics (D.p. specific); BRCA cis rs2239547 0.657 rs6445538 chr3:52874288 T/C cg11645453 chr3:52864694 ITIH4 0.49 11.81 0.42 2.96e-29 Schizophrenia; BRCA cis rs611744 0.647 rs10106246 chr8:109268710 T/C cg21045802 chr8:109455806 TTC35 0.35 7.89 0.3 1.28e-14 Dupuytren's disease; BRCA cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg04978709 chr7:75101039 POM121C 0.35 9.44 0.35 7.07e-20 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10479542 0.896 rs4701130 chr5:178982416 C/T cg19723775 chr5:179050963 HNRNPH1 -0.37 -9.04 -0.34 1.84e-18 Lung cancer; BRCA cis rs2243480 0.764 rs2460423 chr7:65601216 A/T cg18252515 chr7:66147081 NA -1.06 -15.56 -0.52 1.52e-46 Diabetic kidney disease; BRCA cis rs7267979 1.000 rs8125868 chr20:25324410 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.32 -0.35 1.92e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4948102 0.732 rs6951810 chr7:56076598 T/C cg09872392 chr7:56161020 PHKG1 -0.39 -8.69 -0.33 2.95e-17 Plasma homocysteine levels (post-methionine load test); BRCA cis rs8180040 0.726 rs2385867 chr3:47059323 C/T cg16586182 chr3:47516702 SCAP -0.55 -12.6 -0.45 1.14e-32 Colorectal cancer; BRCA cis rs637571 0.522 rs3016868 chr11:65764383 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.63 0.36 1.43e-20 Eosinophil percentage of white cells; BRCA cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg11644478 chr21:40555479 PSMG1 -0.5 -10.58 -0.39 3.24e-24 Menarche (age at onset); BRCA cis rs597539 0.652 rs673821 chr11:68678718 G/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.74 17.64 0.57 5.13e-57 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs3741404 0.609 rs666497 chr11:63869821 G/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.11 0.49 1.45e-39 Platelet count; BRCA cis rs1801251 0.778 rs2592115 chr2:233736349 C/T cg25237894 chr2:233734115 C2orf82 -0.45 -14.1 -0.49 1.69e-39 Coronary artery disease; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg26314531 chr2:26401878 FAM59B 0.65 11.02 0.4 5.49e-26 Gut microbiome composition (summer); BRCA cis rs2439831 0.702 rs7171750 chr15:44025858 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.24 0.44 4.41e-31 Lung cancer in ever smokers; BRCA trans rs66887589 0.776 rs10518337 chr4:120574874 A/C cg25214090 chr10:38739885 LOC399744 -0.35 -7.81 -0.3 2.29e-14 Diastolic blood pressure; BRCA cis rs7666738 0.830 rs1111541 chr4:99033860 A/G cg05340658 chr4:99064831 C4orf37 -0.68 -17.3 -0.56 2.89e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs12200782 0.505 rs7765920 chr6:26514771 C/T cg11502198 chr6:26597334 ABT1 0.63 10.45 0.38 1.04e-23 Small cell lung carcinoma; BRCA cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg18132916 chr6:79620363 NA -0.49 -11.22 -0.41 8.78e-27 Intelligence (multi-trait analysis); BRCA cis rs4332037 0.538 rs4721164 chr7:1932629 C/G cg23422044 chr7:1970798 MAD1L1 -0.61 -13.41 -0.47 2.52e-36 Bipolar disorder; BRCA cis rs1008375 0.966 rs10939735 chr4:17578891 A/G cg27347728 chr4:17578864 LAP3 0.45 8.82 0.33 1.07e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs4650994 0.507 rs56229230 chr1:178526563 G/A cg05059571 chr16:84539110 KIAA1609 -0.58 -12.94 -0.46 3.38e-34 HDL cholesterol levels;HDL cholesterol; BRCA cis rs921968 0.541 rs3845835 chr2:219342284 T/C cg10223061 chr2:219282414 VIL1 0.3 8.57 0.32 8.07e-17 Mean corpuscular hemoglobin concentration; BRCA trans rs35110281 0.632 rs9306160 chr21:45107562 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.44 8.78 0.33 1.45e-17 Mean corpuscular volume; BRCA cis rs2130392 0.926 rs1107907 chr4:185620108 G/T cg04058563 chr4:185651563 MLF1IP 0.37 9.21 0.34 4.66e-19 Kawasaki disease; BRCA cis rs7659604 0.537 rs6815973 chr4:122663430 A/T cg20573242 chr4:122745356 CCNA2 -0.43 -8.98 -0.33 3.05e-18 Type 2 diabetes; BRCA trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg15704280 chr7:45808275 SEPT13 0.57 9.73 0.36 6.09e-21 Axial length; BRCA trans rs11098499 0.863 rs1383532 chr4:120434404 A/T cg19731845 chr4:166199412 KLHL2;GK3P -0.35 -7.95 -0.3 8.49e-15 Corneal astigmatism; BRCA cis rs875971 0.571 rs160641 chr7:65577346 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.54 -10.43 -0.38 1.21e-23 Aortic root size; BRCA cis rs2032447 0.670 rs198815 chr6:26127271 A/G cg12310025 chr6:25882481 NA 0.42 9.32 0.35 1.85e-19 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.501 rs62223052 chr21:40708702 A/C cg17971929 chr21:40555470 PSMG1 -0.47 -9.99 -0.37 6.13e-22 Menarche (age at onset); BRCA cis rs36051895 0.658 rs72699568 chr9:5007138 C/T cg02405213 chr9:5042618 JAK2 -0.47 -8.71 -0.33 2.62e-17 Pediatric autoimmune diseases; BRCA cis rs1129187 0.755 rs9471982 chr6:42935998 G/A cg05552183 chr6:42928497 GNMT 0.68 15.52 0.52 2.41e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs6542838 0.641 rs6724477 chr2:99537074 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.41 9.25 0.34 3.41e-19 Fear of minor pain; BRCA cis rs6964587 0.626 rs4729011 chr7:91515419 G/A cg17063962 chr7:91808500 NA -0.55 -12.73 -0.45 2.88e-33 Breast cancer; BRCA cis rs13046373 0.535 rs1605428 chr21:32028976 T/C cg24082983 chr21:31802169 KRTAP13-4 0.34 8.21 0.31 1.21e-15 HDL cholesterol; BRCA cis rs78456975 0.527 rs72778003 chr2:1571487 G/A cg26248373 chr2:1572462 NA -0.63 -14.39 -0.49 7e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs826838 1.000 rs12366971 chr12:38737687 T/G cg13010199 chr12:38710504 ALG10B 0.56 12.42 0.44 7.15e-32 Heart rate; BRCA cis rs8044868 0.541 rs7202268 chr16:72086746 A/G cg16558253 chr16:72132732 DHX38 -0.45 -10.81 -0.39 3.83e-25 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs4363385 0.747 rs2879488 chr1:152975241 G/A cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA cis rs10504073 0.647 rs10808745 chr8:49989037 G/A cg00325661 chr8:49890786 NA 0.44 12.48 0.44 3.72e-32 Blood metabolite ratios; BRCA cis rs7666738 0.791 rs2865953 chr4:99040319 C/T cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.39e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2760061 0.545 rs1745423 chr1:228224153 G/T cg01200585 chr1:228362443 C1orf69 -0.37 -8.16 -0.31 1.82e-15 Diastolic blood pressure; BRCA cis rs6964587 1.000 rs28735847 chr7:91592755 T/C cg01689657 chr7:91764605 CYP51A1 0.22 8.15 0.31 1.88e-15 Breast cancer; BRCA cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg11764359 chr7:65958608 NA 0.64 11.46 0.41 8.75e-28 Aortic root size; BRCA cis rs12579753 0.917 rs7954438 chr12:82184419 T/C cg07988820 chr12:82153109 PPFIA2 -0.48 -8.37 -0.31 3.52e-16 Resting heart rate; BRCA cis rs897080 0.515 rs786401 chr2:44712069 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.11 0.34 1.07e-18 Height; BRCA cis rs1865760 0.964 rs9379802 chr6:25933898 T/A cg17691542 chr6:26056736 HIST1H1C 0.47 9.74 0.36 5.58e-21 Height; BRCA cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg09184832 chr6:79620586 NA -0.53 -12.16 -0.43 9.15e-31 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.682 rs13124563 chr4:9927553 A/G cg00071950 chr4:10020882 SLC2A9 0.54 13.29 0.47 8.88e-36 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs17376456 1.000 rs12188453 chr5:93560807 G/T cg25358565 chr5:93447407 FAM172A -1.21 -18.88 -0.6 1.65e-63 Diabetic retinopathy; BRCA cis rs9399137 0.561 rs11753985 chr6:135280438 C/T cg22676075 chr6:135203613 NA 0.41 8.3 0.31 6.14e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4595586 0.545 rs12812750 chr12:39363258 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.02 0.34 2.15e-18 Morning vs. evening chronotype; BRCA cis rs8044868 0.530 rs2288000 chr16:72058881 A/G cg16558253 chr16:72132732 DHX38 -0.4 -9.6 -0.36 1.72e-20 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs1568889 1.000 rs12790932 chr11:28046189 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.95 0.51 1.41e-43 Bipolar disorder; BRCA cis rs220324 0.688 rs56326363 chr21:43560295 G/A cg09727148 chr21:43560719 UMODL1 0.5 8.88 0.33 6.65e-18 Idiopathic osteonecrosis of the femoral head; BRCA cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.1 0.43 1.76e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs911119 0.955 rs35610040 chr20:23616469 T/C cg16589663 chr20:23618590 CST3 0.47 8.72 0.33 2.36e-17 Chronic kidney disease; BRCA cis rs7635838 0.654 rs346083 chr3:11280017 T/C cg00170343 chr3:11313890 ATG7 0.44 8.35 0.31 4.32e-16 HDL cholesterol; BRCA cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg00531865 chr16:30841666 NA -0.51 -11.82 -0.42 2.65e-29 Multiple myeloma; BRCA cis rs6912958 0.559 rs451829 chr6:88041919 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.54 11.05 0.4 4.21e-26 Monocyte percentage of white cells; BRCA cis rs6570726 0.935 rs392014 chr6:145843691 A/C cg23711669 chr6:146136114 FBXO30 0.64 15.31 0.52 2.69e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs1862618 0.573 rs2591962 chr5:56237155 G/A cg22800045 chr5:56110881 MAP3K1 -0.58 -9.93 -0.37 1.04e-21 Initial pursuit acceleration; BRCA cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg20701182 chr2:24300061 SF3B14 0.7 13.21 0.46 2.15e-35 Lymphocyte counts; BRCA cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs7766436 0.767 rs6909574 chr6:22606773 A/G cg13666174 chr6:22585274 NA -0.37 -9.47 -0.35 5.15e-20 Coronary artery disease; BRCA cis rs10504229 1.000 rs114312649 chr8:58182539 C/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs9486719 0.741 rs2049927 chr6:96848958 C/G cg06623918 chr6:96969491 KIAA0776 -0.69 -11.88 -0.43 1.55e-29 Migraine;Coronary artery disease; BRCA cis rs881375 0.933 rs2239657 chr9:123671520 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.54 -11.14 -0.4 1.78e-26 Rheumatoid arthritis; BRCA cis rs6867032 0.874 rs4975786 chr5:2004724 T/C cg26168224 chr5:2018326 NA -0.58 -13.96 -0.48 7.46e-39 Gut microbiome composition (winter); BRCA cis rs921968 0.541 rs12619347 chr2:219419935 T/C cg02176678 chr2:219576539 TTLL4 -0.54 -13.53 -0.47 7.3e-37 Mean corpuscular hemoglobin concentration; BRCA cis rs10465746 0.780 rs2147392 chr1:84404154 C/A cg10977910 chr1:84465055 TTLL7 0.57 11.78 0.42 4.09e-29 Obesity-related traits; BRCA cis rs9487051 0.834 rs351728 chr6:109549099 T/C cg21918786 chr6:109611834 NA -0.33 -8.46 -0.32 1.83e-16 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.683 rs55660024 chr8:58128943 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.807 rs1915835 chr6:109597483 C/T cg12927641 chr6:109611667 NA -0.4 -10.43 -0.38 1.3e-23 Reticulocyte fraction of red cells; BRCA cis rs459571 0.883 rs2520096 chr9:136919416 A/G cg13789015 chr9:136890014 NCRNA00094 0.54 11.25 0.41 6.49e-27 Platelet distribution width; BRCA cis rs7512552 0.839 rs11587116 chr1:150451898 A/T cg15654264 chr1:150340011 RPRD2 0.37 8.15 0.31 1.97e-15 Atopic dermatitis;Allergic disease (asthma, hay fever or eczema); BRCA trans rs1997103 1.000 rs4628219 chr7:55410449 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4689388 0.926 rs9998519 chr4:6292909 C/T cg00701064 chr4:6280414 WFS1 0.69 18.05 0.58 3.51e-59 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10493773 0.618 rs34746573 chr1:86075360 G/A cg17807903 chr1:86174739 ZNHIT6 -0.43 -8.15 -0.31 1.86e-15 Urate levels in overweight individuals; BRCA cis rs1005277 0.579 rs2505241 chr10:38442421 T/C cg25427524 chr10:38739819 LOC399744 -0.68 -16.42 -0.54 8.28e-51 Extrinsic epigenetic age acceleration; BRCA cis rs2985684 0.625 rs4900931 chr14:50022793 A/T cg04989706 chr14:50066350 PPIL5 -0.5 -9.88 -0.36 1.55e-21 Carotid intima media thickness; BRCA cis rs921968 0.643 rs3845836 chr2:219504955 C/T cg02176678 chr2:219576539 TTLL4 0.43 11.43 0.41 1.12e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs9341808 0.718 rs9343971 chr6:80882056 C/T cg08355045 chr6:80787529 NA 0.39 9.99 0.37 6.17e-22 Sitting height ratio; BRCA cis rs2645694 0.626 rs2703119 chr4:77823640 C/T cg03477792 chr4:77819574 ANKRD56 0.66 16.13 0.54 2.43e-49 Emphysema distribution in smoking; BRCA cis rs9814567 1.000 rs11919350 chr3:134235970 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.88 0.62 8.32e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10911251 0.546 rs2274984 chr1:183107446 A/C ch.1.3577855R chr1:183094577 LAMC1 -0.61 -15.84 -0.53 6.8e-48 Colorectal cancer; BRCA cis rs858239 0.600 rs7341483 chr7:23127657 G/T cg23682824 chr7:23144976 KLHL7 -0.44 -11.7 -0.42 8.36e-29 Cerebrospinal fluid biomarker levels; BRCA trans rs66887589 0.616 rs13113885 chr4:120221176 G/C cg25214090 chr10:38739885 LOC399744 0.37 8.21 0.31 1.21e-15 Diastolic blood pressure; BRCA trans rs4714291 0.963 rs1923466 chr6:39965946 A/C cg02267698 chr19:7991119 CTXN1 0.41 8.05 0.3 4.07e-15 Strep throat; BRCA cis rs1348850 0.526 rs6433672 chr2:178378175 G/T cg27490568 chr2:178487706 NA 0.48 8.07 0.3 3.58e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs3099143 1.000 rs2629034 chr15:77042240 G/A cg21673338 chr15:77095150 SCAPER -0.53 -9.67 -0.36 1.02e-20 Recalcitrant atopic dermatitis; BRCA cis rs12760731 0.641 rs11590951 chr1:178322757 C/T cg00404053 chr1:178313656 RASAL2 0.63 8.7 0.33 2.75e-17 Obesity-related traits; BRCA cis rs10129255 0.500 rs6576225 chr14:107186359 G/C cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.43e-17 Kawasaki disease; BRCA cis rs514406 0.793 rs12402415 chr1:53218539 G/T cg24675658 chr1:53192096 ZYG11B 0.55 12.61 0.45 1.01e-32 Monocyte count; BRCA cis rs6461049 0.765 rs1476887 chr7:2151633 T/C cg04267008 chr7:1944627 MAD1L1 -0.46 -9.6 -0.35 1.79e-20 Schizophrenia; BRCA cis rs13108904 0.650 rs3796618 chr4:1349602 T/A cg05025164 chr4:1340916 KIAA1530 0.39 8.11 0.31 2.63e-15 Obesity-related traits; BRCA cis rs1707322 1.000 rs9803784 chr1:46401907 T/C cg03146154 chr1:46216737 IPP 0.46 10.2 0.37 9.95e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7666738 0.830 rs7662199 chr4:99019766 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.63 0.39 2.04e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1065852 0.526 rs2413663 chr22:42402399 T/A cg22189786 chr22:42395067 WBP2NL 0.43 8.66 0.32 3.99e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs9467711 0.606 rs9379897 chr6:26601526 T/C cg12826209 chr6:26865740 GUSBL1 0.61 8.07 0.3 3.52e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs9399137 0.507 rs11757723 chr6:135291293 C/T cg24558204 chr6:135376177 HBS1L 0.59 15.85 0.53 5.69e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs28374715 0.662 rs72737793 chr15:41516823 C/T cg18705301 chr15:41695430 NDUFAF1 -0.83 -17.17 -0.56 1.25e-54 Ulcerative colitis; BRCA cis rs7772486 0.875 rs6570736 chr6:146388320 C/T cg05347473 chr6:146136440 FBXO30 0.4 7.86 0.3 1.59e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg18904891 chr8:8559673 CLDN23 0.64 12.34 0.44 1.59e-31 Obesity-related traits; BRCA cis rs35110281 0.806 rs1454649 chr21:45032982 C/T cg21573476 chr21:45109991 RRP1B -0.35 -9.0 -0.34 2.46e-18 Mean corpuscular volume; BRCA trans rs7615952 0.576 rs4646759 chr3:125822946 G/C cg07211511 chr3:129823064 LOC729375 -0.62 -10.85 -0.39 2.79e-25 Blood pressure (smoking interaction); BRCA cis rs11792861 0.851 rs4542004 chr9:111814478 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.48 9.86 0.36 1.98e-21 Menarche (age at onset); BRCA trans rs6598955 0.585 rs12138111 chr1:26590432 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.67 -16.03 -0.54 7.07e-49 Obesity-related traits; BRCA cis rs3091242 0.933 rs12402120 chr1:25751632 C/T cg02931644 chr1:25747376 RHCE 0.41 11.51 0.41 5.27e-28 Erythrocyte sedimentation rate; BRCA cis rs3125734 0.608 rs7905731 chr10:64018472 T/C cg09941381 chr10:64027924 RTKN2 -0.27 -7.83 -0.3 2.06e-14 Rheumatoid arthritis; BRCA cis rs4727027 0.804 rs13231262 chr7:148886058 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.25 0.38 6.21e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.24 8.03 0.3 4.65e-15 Electroencephalogram traits; BRCA cis rs614226 0.872 rs12307148 chr12:120903179 T/C cg01236616 chr12:121019343 POP5 -1.18 -26.44 -0.72 1.27e-104 Type 1 diabetes nephropathy; BRCA cis rs2239547 0.657 rs6445539 chr3:52874296 G/A cg18404041 chr3:52824283 ITIH1 -0.35 -9.31 -0.35 1.94e-19 Schizophrenia; BRCA cis rs7903847 0.642 rs10882913 chr10:99141845 C/T cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2204008 0.811 rs11525004 chr12:38333807 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.37 0.38 2.25e-23 Bladder cancer; BRCA cis rs11997175 0.624 rs4355732 chr8:33676920 A/C ch.8.33884649F chr8:33765107 NA 0.4 9.21 0.34 4.59e-19 Body mass index; BRCA cis rs6952808 0.595 rs2398705 chr7:2164995 G/A cg14004847 chr7:1930337 MAD1L1 -0.43 -8.14 -0.31 2.03e-15 Bipolar disorder and schizophrenia; BRCA trans rs6479891 1.000 rs72837056 chr10:65260478 T/G cg14819942 chr15:35414228 NA 0.35 8.59 0.32 6.62e-17 Arthritis (juvenile idiopathic); BRCA trans rs877282 0.682 rs2265092 chr10:780293 C/T cg22713356 chr15:30763199 NA -0.8 -16.05 -0.54 5.6e-49 Uric acid levels; BRCA cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg01028140 chr2:1542097 TPO -0.7 -13.93 -0.48 1.03e-38 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4363385 0.747 rs6678107 chr1:152966818 T/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.64 -0.32 4.51e-17 Inflammatory skin disease; BRCA cis rs7666738 0.924 rs62318940 chr4:99064768 C/T cg05340658 chr4:99064831 C4orf37 0.58 11.65 0.42 1.44e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs2645694 0.626 rs2703126 chr4:77819842 T/C cg18351406 chr4:77819688 ANKRD56 0.61 13.39 0.47 3.13e-36 Emphysema distribution in smoking; BRCA trans rs7618501 0.633 rs11130228 chr3:50003246 C/T cg21659725 chr3:3221576 CRBN 0.46 11.67 0.42 1.12e-28 Intelligence (multi-trait analysis); BRCA cis rs1562242 0.653 rs2441112 chr5:57601615 T/C cg09002358 chr5:57541568 NA 0.68 11.88 0.43 1.43e-29 Educational attainment (years of education); BRCA cis rs79839061 0.610 rs1564282 chr4:852313 C/T cg23992470 chr4:843637 GAK 0.57 8.53 0.32 1.05e-16 Intelligence (multi-trait analysis); BRCA cis rs3809566 1.000 rs3809566 chr15:63333724 A/G cg12160578 chr15:63334699 TPM1 -0.42 -8.4 -0.32 2.89e-16 Platelet count; BRCA cis rs250677 0.687 rs250664 chr5:148453823 C/T cg23229984 chr5:148520753 ABLIM3 0.36 9.03 0.34 1.96e-18 Breast cancer; BRCA cis rs7208859 0.673 rs2269916 chr17:29233763 A/G cg13385521 chr17:29058706 SUZ12P 0.63 8.57 0.32 7.5e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg21226059 chr5:178986404 RUFY1 0.38 9.2 0.34 5.12e-19 Lung cancer; BRCA cis rs589448 0.900 rs588493 chr12:69751986 G/A cg22834771 chr12:69754056 YEATS4 -0.42 -10.43 -0.38 1.27e-23 Cerebrospinal fluid biomarker levels; BRCA cis rs7572733 0.534 rs700681 chr2:198711502 C/A cg00792783 chr2:198669748 PLCL1 0.47 10.11 0.37 2.17e-22 Dermatomyositis; BRCA cis rs6570726 0.791 rs6918814 chr6:145906028 G/A cg23711669 chr6:146136114 FBXO30 0.64 14.35 0.49 1.13e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs12477438 0.715 rs6724476 chr2:99627316 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.43 -0.44 6.2e-32 Chronic sinus infection; BRCA cis rs9814567 1.000 rs17694011 chr3:134213981 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1862618 0.853 rs43184 chr5:56141777 G/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.16 -0.37 1.37e-22 Initial pursuit acceleration; BRCA cis rs10504229 1.000 rs77857677 chr8:58170131 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.7 -0.36 7.54e-21 Developmental language disorder (linguistic errors); BRCA cis rs3733585 0.699 rs11724510 chr4:9958583 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.83 -0.39 3.35e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs13095912 0.962 rs6785918 chr3:185330631 A/G cg11274856 chr3:185301563 NA 0.36 9.02 0.34 2.18e-18 Systolic blood pressure; BRCA trans rs2204008 0.837 rs11168341 chr12:37961951 C/T cg06521331 chr12:34319734 NA -0.54 -9.7 -0.36 7.7e-21 Bladder cancer; BRCA cis rs4662945 0.603 rs2406981 chr2:130305487 A/G cg05962382 chr2:130345044 NA -0.35 -8.41 -0.32 2.67e-16 Response to cytidine analogues (gemcitabine); BRCA trans rs877282 0.945 rs34367686 chr10:791868 G/C cg22713356 chr15:30763199 NA 1.42 28.55 0.75 3.22e-116 Uric acid levels; BRCA cis rs8177253 0.665 rs10935074 chr3:133441692 T/G cg24879335 chr3:133465180 TF 0.25 7.81 0.3 2.42e-14 Iron status biomarkers; BRCA cis rs7246657 0.943 rs13343471 chr19:37932130 A/G cg23950597 chr19:37808831 NA -0.74 -12.28 -0.44 2.93e-31 Coronary artery calcification; BRCA cis rs41005 1.000 rs798449 chr2:8106533 G/A cg03155496 chr2:8117019 LOC339788 0.56 14.67 0.5 3.34e-42 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.56 0.57 1.27e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs34172651 0.917 rs7204281 chr16:24784475 C/T cg04756594 chr16:24857601 SLC5A11 0.34 8.36 0.31 3.78e-16 Intelligence (multi-trait analysis); BRCA cis rs7208859 0.673 rs11649765 chr17:29233888 T/A cg13385521 chr17:29058706 SUZ12P 0.63 8.57 0.32 7.5e-17 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs60843830 0.964 rs17713879 chr2:254215 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.66 13.45 0.47 1.79e-36 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7707921 0.752 rs2897554 chr5:81276241 C/T cg15871215 chr5:81402204 ATG10 0.36 9.0 0.34 2.65e-18 Breast cancer; BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg24531977 chr5:56204891 C5orf35 -0.87 -18.79 -0.6 4.98e-63 Initial pursuit acceleration; BRCA trans rs6600671 0.934 rs11249429 chr1:121291080 C/T cg00646200 chr1:148855367 NA -0.33 -8.57 -0.32 7.77e-17 Hip geometry; BRCA cis rs7737355 1.000 rs40396 chr5:130708044 C/G cg06307176 chr5:131281290 NA -0.45 -8.82 -0.33 1.06e-17 Life satisfaction; BRCA cis rs4908760 0.899 rs6577496 chr1:8581227 C/A cg20416874 chr1:8611966 RERE -0.29 -8.31 -0.31 5.59e-16 Vitiligo; BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.22 0.34 4.17e-19 Tonsillectomy; BRCA cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg17845761 chr1:175162550 KIAA0040 -0.26 -9.9 -0.36 1.41e-21 Alcohol dependence; BRCA trans rs12543645 0.609 rs35112858 chr8:10277269 C/T cg06636001 chr8:8085503 FLJ10661 0.46 8.35 0.31 4.19e-16 Schizophrenia; BRCA cis rs9287719 0.967 rs963831 chr2:10745184 T/C cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.51e-23 Prostate cancer; BRCA cis rs6459788 0.720 rs6965466 chr7:157250749 G/T cg03453431 chr7:157225567 NA -0.46 -9.19 -0.34 5.36e-19 Epstein-Barr virus copy number in lymphoblastoid cell lines; BRCA trans rs7613875 0.578 rs2624822 chr3:50107219 T/C cg21659725 chr3:3221576 CRBN -0.35 -8.7 -0.33 2.74e-17 Body mass index; BRCA cis rs780096 0.546 rs8179225 chr2:27737181 A/G cg17158414 chr2:27665306 KRTCAP3 -0.31 -7.88 -0.3 1.37e-14 Total body bone mineral density; BRCA cis rs875971 0.545 rs316306 chr7:65618674 G/A cg11764359 chr7:65958608 NA -0.66 -12.11 -0.43 1.53e-30 Aortic root size; BRCA cis rs9788682 0.747 rs28480606 chr15:78762313 A/G cg24631222 chr15:78858424 CHRNA5 0.47 9.32 0.35 1.86e-19 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs7666738 0.830 rs6532723 chr4:99052147 A/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.99e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs17685 0.725 rs1044483 chr7:75659815 T/C cg19862616 chr7:65841803 NCRNA00174 -0.84 -27.35 -0.73 1.32e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1862618 0.853 rs2548664 chr5:56133555 G/A cg22800045 chr5:56110881 MAP3K1 0.65 12.32 0.44 1.9e-31 Initial pursuit acceleration; BRCA cis rs2191566 0.576 rs382255 chr19:44494156 T/C cg20607764 chr19:44506953 ZNF230 0.36 7.87 0.3 1.5e-14 Acute lymphoblastic leukemia (childhood); BRCA cis rs12791968 0.765 rs11038250 chr11:45009114 A/G cg11846598 chr11:44996168 LOC221122 -0.45 -8.3 -0.31 6.23e-16 Inhibitory control; BRCA trans rs11098499 0.863 rs7657849 chr4:120455494 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs4332037 0.707 rs73046323 chr7:1882795 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -10.62 -0.39 2.19e-24 Bipolar disorder; BRCA cis rs780096 0.526 rs809058 chr2:27616790 T/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.56 -0.32 8.45e-17 Total body bone mineral density; BRCA cis rs12701220 0.655 rs7799656 chr7:1140515 C/T cg26769984 chr7:1090371 C7orf50 0.48 9.0 0.34 2.57e-18 Bronchopulmonary dysplasia; BRCA trans rs11039798 0.925 rs12277669 chr11:48925316 A/T cg15704280 chr7:45808275 SEPT13 0.6 8.89 0.33 6.42e-18 Axial length; BRCA trans rs1493916 0.748 rs4799355 chr18:31313124 G/T cg27147174 chr7:100797783 AP1S1 -0.4 -8.07 -0.3 3.51e-15 Life satisfaction; BRCA cis rs6456156 0.526 rs3093025 chr6:167532731 A/G cg07741184 chr6:167504864 NA -0.29 -8.68 -0.32 3.38e-17 Primary biliary cholangitis; BRCA cis rs2243480 1.000 rs2420171 chr7:65637760 T/C cg18252515 chr7:66147081 NA 1.06 15.97 0.53 1.49e-48 Diabetic kidney disease; BRCA trans rs1005277 0.579 rs1740749 chr10:38521646 A/G cg17830980 chr10:43048298 ZNF37B -0.53 -12.65 -0.45 6.63e-33 Extrinsic epigenetic age acceleration; BRCA cis rs2842992 0.789 rs4235925 chr6:160202860 C/T cg11366901 chr6:160182831 ACAT2 0.86 16.91 0.56 2.81e-53 Age-related macular degeneration (geographic atrophy); BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs8180040 0.966 rs7649234 chr3:47494380 G/C cg27129171 chr3:47204927 SETD2 0.7 16.82 0.55 8.15e-53 Colorectal cancer; BRCA cis rs826838 1.000 rs2129627 chr12:38653036 C/T cg13010199 chr12:38710504 ALG10B 0.57 12.57 0.45 1.55e-32 Heart rate; BRCA cis rs7043114 0.525 rs7020874 chr9:95112560 G/A cg14631576 chr9:95140430 CENPP -0.34 -8.38 -0.31 3.29e-16 Height; BRCA cis rs7264396 0.635 rs6058366 chr20:34512172 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 7.95 0.3 8.39e-15 Total cholesterol levels; BRCA cis rs1862618 0.641 rs2591954 chr5:56245044 G/C cg24531977 chr5:56204891 C5orf35 0.71 15.41 0.52 8.27e-46 Initial pursuit acceleration; BRCA cis rs875971 1.000 rs35149210 chr7:65929925 T/C cg11764359 chr7:65958608 NA 0.79 19.19 0.6 3.68e-65 Aortic root size; BRCA cis rs4268898 0.965 rs4665673 chr2:24459737 A/T cg06627628 chr2:24431161 ITSN2 0.49 10.3 0.38 3.96e-23 Asthma; BRCA cis rs4665809 1.000 rs6546728 chr2:26276531 G/C cg25036284 chr2:26402008 FAM59B -0.79 -12.32 -0.44 2e-31 Gut microbiome composition (summer); BRCA cis rs4862750 0.872 rs6553029 chr4:187876470 G/T cg07414643 chr4:187882934 NA -0.25 -8.19 -0.31 1.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs11955398 0.625 rs34395679 chr5:59954716 A/G cg02684056 chr5:59996105 DEPDC1B 0.37 8.59 0.32 6.44e-17 Intelligence (multi-trait analysis); BRCA cis rs3733585 0.699 rs28610447 chr4:9971517 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -9.87 -0.36 1.73e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1476670 0.661 rs10157253 chr1:44505646 C/G cg09470012 chr1:44509516 NA 0.38 8.57 0.32 7.64e-17 Eotaxin levels; BRCA cis rs7772486 0.659 rs9376957 chr6:146011064 C/T cg23711669 chr6:146136114 FBXO30 -0.7 -16.55 -0.55 1.88e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs1218582 0.774 rs12036859 chr1:154859940 A/C cg12436631 chr1:155007014 DCST1;DCST2 -0.26 -7.94 -0.3 9.17e-15 Prostate cancer; BRCA cis rs11123170 0.529 rs1015753 chr2:113968803 T/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.52 8.54 0.32 1.02e-16 Renal function-related traits (BUN); BRCA cis rs4665809 0.590 rs13016300 chr2:26468365 G/C cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs9649213 0.593 rs10953255 chr7:97923198 A/G cg01877450 chr7:97915802 BRI3 -0.37 -8.55 -0.32 9.02e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2070488 0.804 rs13063978 chr3:38476538 A/G cg24069376 chr3:38537580 EXOG 0.34 9.41 0.35 8.96e-20 Electrocardiographic conduction measures; BRCA cis rs9467773 0.595 rs2172007 chr6:26639777 A/C cg09904177 chr6:26538194 HMGN4 0.43 12.65 0.45 6.53e-33 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs13118892 chr4:98968497 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.44 0.38 1.1e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs6430585 0.702 rs2015532 chr2:136555525 G/T cg07169764 chr2:136633963 MCM6 -1.25 -28.96 -0.75 1.95e-118 Corneal structure; BRCA cis rs12410462 1.000 rs75652886 chr1:227654485 G/T cg04117972 chr1:227635322 NA 0.52 9.28 0.34 2.55e-19 Major depressive disorder; BRCA cis rs919433 0.927 rs7592748 chr2:198170688 G/A cg10820045 chr2:198174542 NA -0.38 -7.87 -0.3 1.49e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg04166393 chr7:2884313 GNA12 0.48 9.01 0.34 2.43e-18 Height; BRCA cis rs1707322 0.752 rs12047629 chr1:46162802 G/A cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4808199 0.843 rs10402308 chr19:19657500 G/A cg03709012 chr19:19516395 GATAD2A 0.89 17.39 0.57 9.16e-56 Nonalcoholic fatty liver disease; BRCA cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg04478727 chr12:58166393 METTL1;FAM119B -0.58 -11.25 -0.41 6.79e-27 Multiple sclerosis; BRCA cis rs1862618 0.671 rs2255726 chr5:56243128 T/C cg24549020 chr5:56110836 MAP3K1 -0.39 -8.07 -0.3 3.48e-15 Initial pursuit acceleration; BRCA cis rs13095912 0.752 rs13061708 chr3:185339984 T/C cg11274856 chr3:185301563 NA 0.54 12.88 0.45 6.28e-34 Systolic blood pressure; BRCA cis rs7592578 0.639 rs13417431 chr2:191293055 A/G cg11845111 chr2:191398756 TMEM194B -0.69 -13.21 -0.46 2.07e-35 Diastolic blood pressure; BRCA cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg21770322 chr7:97807741 LMTK2 0.42 11.31 0.41 3.74e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs7973719 0.868 rs6486910 chr12:7356479 G/A cg07052231 chr12:7363540 PEX5 0.36 8.17 0.31 1.63e-15 IgG glycosylation; BRCA cis rs2243480 1.000 rs34970380 chr7:65431493 C/T cg18252515 chr7:66147081 NA -0.9 -12.87 -0.45 7.11e-34 Diabetic kidney disease; BRCA cis rs758324 0.947 rs1948704 chr5:131171653 A/G cg06307176 chr5:131281290 NA 0.53 10.32 0.38 3.41e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs77956314 0.515 rs10850741 chr12:117432004 A/G cg02556042 chr12:117471086 NA 0.57 9.9 0.36 1.4e-21 Subcortical brain region volumes;Hippocampal volume; BRCA trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg15704280 chr7:45808275 SEPT13 -0.75 -15.39 -0.52 1.12e-45 Height; BRCA cis rs11676348 0.818 rs7426289 chr2:218966315 C/T cg00012203 chr2:219082015 ARPC2 -0.4 -7.86 -0.3 1.61e-14 Ulcerative colitis; BRCA cis rs2580764 0.565 rs35631428 chr2:55244438 G/A cg09592903 chr2:55203963 RTN4 -0.33 -8.58 -0.32 7.37e-17 Mean platelet volume; BRCA cis rs10911232 0.507 rs6660111 chr1:183014289 G/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.43 0.54 7.24e-51 Hypertriglyceridemia; BRCA cis rs10504229 0.683 rs55714371 chr8:58131846 T/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs4727027 0.933 rs2158633 chr7:148832652 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.48 0.32 1.55e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7131987 0.801 rs962866 chr12:29434147 A/G cg09582351 chr12:29534625 ERGIC2 -0.42 -10.06 -0.37 3.5e-22 QT interval; BRCA cis rs4742903 0.933 rs10820608 chr9:106890840 A/G cg21169611 chr9:106856078 SMC2 0.37 9.69 0.36 7.94e-21 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.96 -0.4 9.86e-26 Personality dimensions; BRCA cis rs514406 0.929 rs1672908 chr1:53340885 A/G cg08859206 chr1:53392774 SCP2 -0.52 -11.17 -0.4 1.4e-26 Monocyte count; BRCA cis rs7918232 0.505 rs788221 chr10:27442247 G/C cg14442939 chr10:27389572 ANKRD26 -0.69 -9.28 -0.34 2.68e-19 Breast cancer; BRCA cis rs9649465 1.000 rs6950659 chr7:123361910 C/T cg04330084 chr7:123175371 IQUB -0.31 -8.44 -0.32 2.13e-16 Migraine; BRCA cis rs870825 0.929 rs871254 chr4:185589226 G/C cg04058563 chr4:185651563 MLF1IP 0.68 11.41 0.41 1.46e-27 Blood protein levels; BRCA cis rs7586879 0.681 rs6545790 chr2:25109302 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.63 0.42 1.74e-28 Body mass index; BRCA cis rs9986765 1.000 rs10243198 chr7:142822210 C/T cg15652212 chr7:142981776 TMEM139 0.58 10.0 0.37 5.72e-22 Cancer;Dermatomyositis; BRCA cis rs2625529 0.761 rs4776582 chr15:72207520 A/T cg16672083 chr15:72433130 SENP8 -0.83 -17.19 -0.56 9.91e-55 Red blood cell count; BRCA cis rs9649213 0.593 rs6465672 chr7:97963717 C/T cg24562669 chr7:97807699 LMTK2 -0.43 -11.56 -0.42 3.36e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs1506636 0.511 rs62484466 chr7:123174880 T/A cg03229431 chr7:123269106 ASB15 0.51 10.95 0.4 1.08e-25 Plateletcrit;Platelet count; BRCA cis rs12142240 0.698 rs72679807 chr1:46846490 G/A cg14993813 chr1:46806288 NSUN4 -0.5 -9.69 -0.36 8.4e-21 Menopause (age at onset); BRCA cis rs7592578 0.766 rs35818159 chr2:191409616 C/G cg11845111 chr2:191398756 TMEM194B -0.82 -14.64 -0.5 4.79e-42 Diastolic blood pressure; BRCA cis rs8114671 0.836 rs2104083 chr20:33649133 G/A cg07148914 chr20:33460835 GGT7 -0.42 -9.1 -0.34 1.16e-18 Height; BRCA cis rs6840360 0.615 rs4696290 chr4:152631472 A/G cg22705602 chr4:152727874 NA -0.37 -10.07 -0.37 3.1e-22 Intelligence (multi-trait analysis); BRCA cis rs3772130 0.962 rs35679661 chr3:121484763 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.56 9.81 0.36 3.02e-21 Cognitive performance; BRCA cis rs6878727 0.665 rs319628 chr5:123674135 C/T cg01806427 chr5:123737813 NA -0.36 -8.15 -0.31 1.97e-15 Breast cancer; BRCA cis rs17125944 0.505 rs80211268 chr14:53265483 C/G cg00686598 chr14:53173677 PSMC6 1.23 16.73 0.55 2.26e-52 Alzheimer's disease (late onset); BRCA cis rs12887734 0.546 rs4906376 chr14:104272165 A/C cg01849466 chr14:104193079 ZFYVE21 -0.45 -10.17 -0.37 1.23e-22 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9393692 0.905 rs1124999 chr6:26287043 G/T cg05868516 chr6:26286170 HIST1H4H 0.5 11.39 0.41 1.66e-27 Educational attainment; BRCA cis rs1008375 1.000 rs3933453 chr4:17636319 A/C cg02297831 chr4:17616191 MED28 0.37 8.73 0.33 2.19e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2070488 0.965 rs4679053 chr3:38523495 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.73 20.25 0.63 7.78e-71 Electrocardiographic conduction measures; BRCA cis rs9325144 0.600 rs7965877 chr12:38743697 G/T cg26384229 chr12:38710491 ALG10B 0.48 12.36 0.44 1.26e-31 Morning vs. evening chronotype; BRCA cis rs1800469 1.000 rs2241714 chr19:41869392 C/T cg09537434 chr19:41945824 ATP5SL 0.57 10.55 0.39 4.38e-24 Colorectal cancer; BRCA cis rs873946 0.648 rs1548281 chr10:134552982 C/T cg27286337 chr10:134555280 INPP5A 0.79 12.53 0.44 2.23e-32 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7267979 1.000 rs2482941 chr20:25361216 T/C cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7662987 0.517 rs2602873 chr4:100039032 G/C cg12011299 chr4:100065546 ADH4 0.48 10.81 0.39 4.06e-25 Smoking initiation; BRCA cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg05729249 chr7:766119 PRKAR1B;HEATR2 0.53 7.89 0.3 1.31e-14 Cerebrospinal P-tau181p levels; BRCA cis rs10479542 0.683 rs7380706 chr5:178961872 C/T cg14820908 chr5:178986412 RUFY1 0.36 8.11 0.31 2.63e-15 Lung cancer; BRCA trans rs11098499 0.820 rs12503082 chr4:120284317 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg05347473 chr6:146136440 FBXO30 0.4 8.11 0.31 2.64e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6088580 0.634 rs4277599 chr20:33008905 A/G cg24642439 chr20:33292090 TP53INP2 -0.5 -10.99 -0.4 7.73e-26 Glomerular filtration rate (creatinine); BRCA cis rs7131987 0.903 rs2216853 chr12:29413248 C/G cg09582351 chr12:29534625 ERGIC2 -0.39 -9.37 -0.35 1.26e-19 QT interval; BRCA cis rs9649213 0.593 rs2158553 chr7:97951131 G/A cg24562669 chr7:97807699 LMTK2 0.44 11.75 0.42 5.51e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs2415984 0.622 rs1761026 chr14:46930139 T/C cg14871534 chr14:47121158 RPL10L 0.34 8.39 0.31 3.22e-16 Number of children ever born; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg08132940 chr7:1081526 C7orf50 -0.59 -8.84 -0.33 9.29e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.962 rs2865991 chr4:99067369 C/A cg05340658 chr4:99064831 C4orf37 0.59 12.67 0.45 5.43e-33 Colonoscopy-negative controls vs population controls; BRCA trans rs9650657 0.504 rs10108347 chr8:11033517 G/C cg08975724 chr8:8085496 FLJ10661 -0.43 -9.12 -0.34 9.58e-19 Neuroticism; BRCA cis rs8114671 0.562 rs6087642 chr20:33468306 T/C cg07148914 chr20:33460835 GGT7 0.37 8.45 0.32 1.98e-16 Height; BRCA cis rs11098499 0.554 rs2175381 chr4:120265967 T/C cg09307838 chr4:120376055 NA 0.59 12.91 0.45 4.81e-34 Corneal astigmatism; BRCA cis rs796364 1.000 rs10178177 chr2:200829993 G/A cg23649088 chr2:200775458 C2orf69 0.56 8.18 0.31 1.56e-15 Schizophrenia; BRCA cis rs7811142 0.667 rs3873746 chr7:99935097 G/A cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.7 -11.89 -0.43 1.33e-29 Platelet count; BRCA cis rs853679 0.517 rs2275508 chr6:28094731 T/C cg18032046 chr6:28092343 ZSCAN16 -0.49 -7.96 -0.3 7.64e-15 Depression; BRCA cis rs7586879 1.000 rs10207698 chr2:25117672 C/T cg01884057 chr2:25150051 NA 0.33 8.27 0.31 7.99e-16 Body mass index; BRCA cis rs3916 0.955 rs34030695 chr12:121156496 G/A cg21892295 chr12:121157589 UNC119B -0.38 -9.89 -0.36 1.54e-21 Urinary metabolites (H-NMR features); BRCA trans rs826838 0.754 rs2387920 chr12:38626351 A/G cg06521331 chr12:34319734 NA -0.51 -9.34 -0.35 1.53e-19 Heart rate; BRCA cis rs1348850 0.958 rs11689550 chr2:178456298 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.42 8.46 0.32 1.78e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs4481887 0.962 rs6663952 chr1:248465682 A/G cg13385794 chr1:248469461 NA 0.28 7.8 0.3 2.44e-14 Common traits (Other); BRCA cis rs9311474 0.597 rs6778735 chr3:52565100 T/C cg18404041 chr3:52824283 ITIH1 -0.28 -8.41 -0.32 2.7e-16 Electroencephalogram traits; BRCA cis rs7809950 0.678 rs2301801 chr7:106870746 T/C cg23024343 chr7:107201750 COG5 -0.47 -9.32 -0.35 1.84e-19 Coronary artery disease; BRCA cis rs4363385 0.588 rs11205180 chr1:153022070 A/G cg25856811 chr1:152973957 SPRR3 -0.31 -7.91 -0.3 1.13e-14 Inflammatory skin disease; BRCA cis rs9341808 0.500 rs2322629 chr6:80811540 C/T cg08355045 chr6:80787529 NA 0.39 9.82 0.36 2.75e-21 Sitting height ratio; BRCA cis rs4242434 0.927 rs34027561 chr8:22465385 T/C cg03733263 chr8:22462867 KIAA1967 1.03 23.83 0.69 2.59e-90 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs344364 0.511 rs1657132 chr16:1949924 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs79349575 0.716 rs46522 chr17:46988597 C/T cg00947319 chr17:47005597 UBE2Z -0.29 -7.81 -0.3 2.39e-14 Type 2 diabetes; BRCA cis rs2294693 0.945 rs9369252 chr6:40986028 C/T cg14769373 chr6:40998127 UNC5CL 0.38 7.94 0.3 9.22e-15 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs4319547 0.695 rs7301515 chr12:122949673 T/C cg05707623 chr12:122985044 ZCCHC8 -0.55 -9.88 -0.36 1.58e-21 Body mass index; BRCA cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 9.0 0.34 2.46e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.728 rs77197419 chr8:58150879 C/A cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs507080 0.663 rs7926970 chr11:118559881 T/G cg08498647 chr11:118550644 TREH -0.38 -8.3 -0.31 6e-16 Serum metabolite levels; BRCA cis rs3733585 0.682 rs13124563 chr4:9927553 A/G cg11266682 chr4:10021025 SLC2A9 0.42 11.03 0.4 5.24e-26 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4722166 0.532 rs6461662 chr7:22757089 C/T cg05472934 chr7:22766657 IL6 0.43 10.76 0.39 6.5e-25 Lung cancer; BRCA cis rs1801251 1.000 rs1022330 chr2:233577330 G/A cg08000102 chr2:233561755 GIGYF2 0.62 13.66 0.48 1.88e-37 Coronary artery disease; BRCA cis rs4727027 0.680 rs6464941 chr7:148826352 A/G cg23583168 chr7:148888333 NA -0.73 -15.72 -0.53 2.43e-47 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4853012 0.539 rs9789534 chr2:74362990 A/T cg19729930 chr2:74357872 NA 0.41 9.3 0.35 2.21e-19 Gestational age at birth (maternal effect); BRCA cis rs9814567 1.000 rs2373865 chr3:134291556 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.85e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs67460515 0.892 rs7610985 chr3:161062848 G/A cg04691961 chr3:161091175 C3orf57 -0.38 -8.09 -0.3 3.07e-15 Parkinson's disease; BRCA cis rs6951245 1.000 rs78185558 chr7:1090183 G/C cg22907277 chr7:1156413 C7orf50 0.53 8.75 0.33 1.94e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1707322 1.000 rs946524 chr1:46487560 A/G cg03146154 chr1:46216737 IPP -0.45 -10.13 -0.37 1.84e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9462027 0.628 rs2814969 chr6:34713399 C/A cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.01 -0.3 5.42e-15 Systemic lupus erythematosus; BRCA cis rs2011503 0.597 rs8103992 chr19:19665643 A/C cg11584989 chr19:19387371 SF4 -0.48 -10.56 -0.39 3.8e-24 Bipolar disorder; BRCA cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.85 18.66 0.59 2.23e-62 Smoking behavior; BRCA cis rs17253792 0.822 rs10149408 chr14:56046075 G/A cg01858014 chr14:56050164 KTN1 -0.79 -11.43 -0.41 1.15e-27 Putamen volume; BRCA cis rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04267008 chr7:1944627 MAD1L1 -0.54 -12.14 -0.43 1.16e-30 Bipolar disorder and schizophrenia; BRCA cis rs1569175 0.522 rs10221945 chr2:200875847 T/C cg23649088 chr2:200775458 C2orf69 -0.53 -7.91 -0.3 1.11e-14 Response to treatment for acute lymphoblastic leukemia; BRCA cis rs1568889 1.000 rs34667360 chr11:28055650 T/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.69 13.49 0.47 1.16e-36 Bipolar disorder; BRCA cis rs56163509 1 rs56163509 chr16:28864471 A/G cg09754948 chr16:28834200 ATXN2L 0.46 8.45 0.32 2.02e-16 Tonsillectomy;Mean corpuscular volume; BRCA cis rs7246657 0.943 rs10422074 chr19:37894236 T/C cg18154014 chr19:37997991 ZNF793 0.62 11.64 0.42 1.52e-28 Coronary artery calcification; BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg18758796 chr5:131593413 PDLIM4 0.34 8.98 0.33 3.12e-18 Breast cancer; BRCA cis rs4819052 0.851 rs13052312 chr21:46662359 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.91 0.37 1.21e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11890956 chr21:40555474 PSMG1 0.85 22.14 0.66 4.58e-81 Cognitive function; BRCA cis rs6088813 1.000 rs4911494 chr20:33971914 C/T cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.1e-17 Height; BRCA cis rs7249921 0.728 rs1627280 chr19:35652248 C/T cg15419183 chr19:35660584 FXYD5 0.41 9.6 0.35 1.83e-20 Platelet count; BRCA cis rs6860806 0.661 rs28472559 chr5:131581611 G/A cg14196790 chr5:131705035 SLC22A5 0.33 8.74 0.33 2.04e-17 Breast cancer; BRCA cis rs7582180 0.591 rs12991577 chr2:101010867 C/A cg14675211 chr2:100938903 LONRF2 0.52 11.5 0.41 5.78e-28 Intelligence (multi-trait analysis); BRCA cis rs826838 1.000 rs10875991 chr12:39108886 G/C cg26384229 chr12:38710491 ALG10B 0.82 21.6 0.65 4.01e-78 Heart rate; BRCA trans rs7746199 0.736 rs34038546 chr6:27607660 C/A cg01620082 chr3:125678407 NA -0.91 -10.26 -0.38 5.96e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs7659604 0.676 rs7691955 chr4:122700462 A/T cg06713675 chr4:122721982 EXOSC9 -0.54 -12.51 -0.44 2.8099999999999997e-32 Type 2 diabetes; BRCA cis rs7246657 0.943 rs4417644 chr19:37852472 A/G cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA cis rs10242455 0.702 rs3528 chr7:99055940 T/C cg18809830 chr7:99032528 PTCD1 -0.57 -8.45 -0.32 1.98e-16 Blood metabolite levels; BRCA cis rs4237845 0.586 rs4760174 chr12:58320436 G/A cg02175503 chr12:58329896 NA 0.81 21.06 0.64 3.42e-75 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.943 rs7255407 chr19:37933936 G/A cg14683738 chr19:37701593 ZNF585B 0.44 7.89 0.3 1.3e-14 Coronary artery calcification; BRCA cis rs7584330 0.554 rs6760913 chr2:238400702 C/T cg14458575 chr2:238380390 NA 0.52 8.19 0.31 1.37e-15 Prostate cancer; BRCA cis rs9311474 0.502 rs4687624 chr3:52563572 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.31 9.91 0.37 1.23e-21 Electroencephalogram traits; BRCA cis rs6840360 0.533 rs13145446 chr4:152729035 G/A cg22705602 chr4:152727874 NA 0.38 9.86 0.36 1.91e-21 Intelligence (multi-trait analysis); BRCA cis rs1020064 0.636 rs1529974 chr2:105927996 T/C cg02079111 chr2:105885981 TGFBRAP1 0.41 7.93 0.3 1.02e-14 AIDS; BRCA cis rs13191362 1.000 rs35103567 chr6:163183400 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.02 15.24 0.52 5.52e-45 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg08859206 chr1:53392774 SCP2 0.45 10.08 0.37 2.81e-22 Monocyte count; BRCA cis rs61863818 0.709 rs10786343 chr10:99159465 C/A cg20016023 chr10:99160130 RRP12 -0.26 -8.36 -0.31 3.84e-16 Monocyte percentage of white cells; BRCA cis rs7618915 0.501 rs12635140 chr3:52738165 C/T cg18404041 chr3:52824283 ITIH1 0.38 11.79 0.42 3.72e-29 Bipolar disorder; BRCA cis rs7254827 0.737 rs16981571 chr19:17158694 A/G cg19418318 chr19:17219073 MYO9B 0.48 10.19 0.37 1.05e-22 Mean platelet volume; BRCA cis rs11997175 0.583 rs4386938 chr8:33673156 A/G ch.8.33884649F chr8:33765107 NA 0.35 8.28 0.31 7.42e-16 Body mass index; BRCA cis rs61931739 0.534 rs12372721 chr12:34175301 C/T cg06521331 chr12:34319734 NA -0.63 -11.47 -0.41 7.68e-28 Morning vs. evening chronotype; BRCA cis rs6570726 0.967 rs373704 chr6:145860618 C/A cg23711669 chr6:146136114 FBXO30 0.64 14.96 0.51 1.28e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs12618769 0.597 rs3769737 chr2:99088873 C/G cg10123293 chr2:99228465 UNC50 -0.42 -8.13 -0.31 2.22e-15 Bipolar disorder; BRCA cis rs4780401 0.609 rs4780399 chr16:11828701 A/T cg01061890 chr16:11836724 TXNDC11 -0.56 -12.95 -0.46 3.16e-34 Rheumatoid arthritis; BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg12379764 chr21:47803548 PCNT -0.35 -7.82 -0.3 2.15e-14 Testicular germ cell tumor; BRCA cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg24642439 chr20:33292090 TP53INP2 0.6 13.06 0.46 1.02e-34 Coronary artery disease; BRCA trans rs11039798 0.582 rs60764175 chr11:48775856 T/G cg03929089 chr4:120376271 NA 0.57 9.25 0.34 3.33e-19 Axial length; BRCA cis rs2742234 0.955 rs1800861 chr10:43613843 G/T cg02780029 chr10:43622663 RET -0.41 -10.09 -0.37 2.51e-22 Hirschsprung disease; BRCA cis rs7949030 0.626 rs11231154 chr11:62362293 A/G cg22862634 chr11:62369728 EML3;MTA2 0.57 13.57 0.47 4.88e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs17270561 0.609 rs760698 chr6:25685889 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.85 0.33 8.49e-18 Iron status biomarkers; BRCA cis rs801193 0.569 rs6951302 chr7:66132512 T/C cg11764359 chr7:65958608 NA -0.73 -16.1 -0.54 3.4e-49 Aortic root size; BRCA cis rs4665809 0.941 rs6735145 chr2:26270302 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.23 -0.44 4.82e-31 Gut microbiome composition (summer); BRCA cis rs7385804 0.761 rs568733 chr7:100311662 G/T cg16850897 chr7:100343110 ZAN 0.37 8.53 0.32 1.03e-16 Iron status biomarkers;Mean corpuscular hemoglobin;Hematocrit;Iron status biomarkers (transferrin saturation);Red blood cell count;Iron status biomarkers (iron levels);Mean corpuscular volume;Hematological parameters; BRCA cis rs12477438 0.798 rs6705821 chr2:99602832 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.66 -0.5 3.76e-42 Chronic sinus infection; BRCA trans rs3780486 0.874 rs10813955 chr9:33141791 C/T cg04842962 chr6:43655489 MRPS18A 1.12 38.9 0.84 1.18e-170 IgG glycosylation; BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26314531 chr2:26401878 FAM59B -0.79 -12.57 -0.45 1.53e-32 Gut microbiome composition (summer); BRCA cis rs10739663 0.520 rs3122937 chr9:128154808 A/G cg14078157 chr9:128172775 NA -0.43 -10.18 -0.37 1.21e-22 Resting heart rate; BRCA trans rs61931739 0.517 rs7486246 chr12:34526419 T/G cg26384229 chr12:38710491 ALG10B 0.59 13.54 0.47 6.37e-37 Morning vs. evening chronotype; BRCA cis rs36051895 0.589 rs2224571 chr9:5196253 A/C cg02405213 chr9:5042618 JAK2 -0.46 -8.67 -0.32 3.63e-17 Pediatric autoimmune diseases; BRCA cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg16230307 chr14:35515116 FAM177A1 0.73 14.74 0.5 1.59e-42 Psoriasis; BRCA cis rs7811142 0.720 rs112622797 chr7:99917416 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 14.31 0.49 1.62e-40 Platelet count; BRCA trans rs7618501 0.633 rs4688755 chr3:50064424 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.26 -0.34 2.94e-19 Intelligence (multi-trait analysis); BRCA cis rs6750047 0.647 rs62136320 chr2:38275953 T/G cg07380506 chr2:38303506 CYP1B1 0.48 10.53 0.38 4.98e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs769267 0.930 rs892021 chr19:19613480 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.13 0.34 8.89e-19 Tonsillectomy; BRCA cis rs16854884 0.632 rs60505453 chr3:143643864 C/G cg06585982 chr3:143692056 C3orf58 0.42 8.48 0.32 1.53e-16 Economic and political preferences (feminism/equality); BRCA cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg18446336 chr7:2847575 GNA12 -0.35 -7.94 -0.3 9.17e-15 Height; BRCA cis rs9368481 0.524 rs12530345 chr6:26884243 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 0.22 7.87 0.3 1.49e-14 Autism spectrum disorder or schizophrenia; BRCA cis rs4363385 0.818 rs10788853 chr1:153002231 C/T cg24667326 chr1:152973720 SPRR3 -0.33 -8.81 -0.33 1.19e-17 Inflammatory skin disease; BRCA cis rs9443645 0.901 rs10943612 chr6:79698380 C/T cg05283184 chr6:79620031 NA -0.43 -10.89 -0.4 1.9e-25 Intelligence (multi-trait analysis); BRCA cis rs2742417 0.603 rs2742372 chr3:45783472 T/C cg04837898 chr3:45731254 SACM1L -0.38 -7.81 -0.3 2.31e-14 Response to anti-depressant treatment in major depressive disorder; BRCA trans rs800082 0.698 rs800077 chr3:144349940 A/G cg24215973 chr2:240111563 HDAC4 -0.64 -14.75 -0.5 1.41e-42 Smoking behavior; BRCA cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.78 0.33 1.53e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2404602 0.591 rs11635162 chr15:76951105 C/T cg23625390 chr15:77176239 SCAPER -0.52 -11.02 -0.4 5.68e-26 Blood metabolite levels; BRCA cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg21926612 chr6:163149169 PACRG;PARK2 1.03 16.04 0.54 6.9e-49 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11249608 0.548 rs13156530 chr5:178475017 C/T cg21905437 chr5:178450457 ZNF879 0.51 10.14 0.37 1.73e-22 Pubertal anthropometrics; BRCA cis rs916888 0.773 rs9896243 chr17:44826056 C/G cg17911788 chr17:44343683 NA -0.46 -8.23 -0.31 1.05e-15 Post bronchodilator FEV1;Cognitive function;Intelligence (multi-trait analysis);Multiple system atrophy; BRCA cis rs7824557 0.836 rs1435278 chr8:11123029 G/T cg21775007 chr8:11205619 TDH -0.62 -12.17 -0.43 8.92e-31 Retinal vascular caliber; BRCA cis rs372883 0.648 rs1003772 chr21:30736145 A/T cg08807101 chr21:30365312 RNF160 0.43 9.1 0.34 1.12e-18 Pancreatic cancer; BRCA cis rs3749237 0.964 rs11714957 chr3:49776178 C/T cg07636037 chr3:49044803 WDR6 0.42 8.63 0.32 5.02e-17 Resting heart rate; BRCA cis rs801193 1.000 rs4717310 chr7:66161007 C/T cg18876405 chr7:65276391 NA 0.62 15.35 0.52 1.76e-45 Aortic root size; BRCA cis rs921968 0.643 rs13431399 chr2:219469498 G/C cg10223061 chr2:219282414 VIL1 0.31 8.89 0.33 6.35e-18 Mean corpuscular hemoglobin concentration; BRCA cis rs4409675 0.576 rs3766396 chr1:28221554 C/T cg23691781 chr1:28212827 C1orf38 -0.32 -10.66 -0.39 1.6e-24 Corneal astigmatism; BRCA cis rs12545109 0.765 rs1960727 chr8:57411368 G/A cg09654669 chr8:57350985 NA -0.4 -7.81 -0.3 2.32e-14 Obesity-related traits; BRCA cis rs17092148 1.000 rs6088603 chr20:33370945 A/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs11123170 0.529 rs35606997 chr2:113973350 G/A cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.55 9.39 0.35 1.07e-19 Renal function-related traits (BUN); BRCA cis rs738322 0.967 rs133024 chr22:38574066 C/T cg25457927 chr22:38595422 NA 0.3 11.33 0.41 2.9e-27 Cutaneous nevi; BRCA cis rs6066825 0.590 rs6063307 chr20:47304045 A/G cg18078177 chr20:47281410 PREX1 0.39 9.88 0.36 1.65e-21 Colorectal cancer; BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg08888203 chr3:10149979 C3orf24 0.58 12.28 0.44 2.89e-31 Alzheimer's disease; BRCA trans rs629535 0.862 rs2472141 chr8:70054216 T/C cg21567404 chr3:27674614 NA 1.0 20.93 0.64 1.77e-74 Dupuytren's disease; BRCA cis rs7666738 0.716 rs13136721 chr4:99085602 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.34 0.35 1.5700000000000001e-19 Colonoscopy-negative controls vs population controls; BRCA cis rs1557765 0.527 rs11024272 chr11:17395760 T/C cg04705435 chr11:17411270 KCNJ11 0.34 7.9 0.3 1.19e-14 Body mass index;Social communication problems; BRCA cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2425143 1.000 rs6060578 chr20:34305445 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -9.03 -0.34 2.03e-18 Blood protein levels; BRCA trans rs11165623 0.564 rs7525803 chr1:97000791 T/C cg10631902 chr5:14652156 NA -0.43 -12.14 -0.43 1.11e-30 Hip circumference;Waist circumference; BRCA trans rs561341 0.882 rs72825748 chr17:30367396 G/A cg20587970 chr11:113659929 NA -1.37 -24.72 -0.7 3.4e-95 Hip circumference adjusted for BMI; BRCA cis rs7523273 0.597 rs2724374 chr1:207941191 G/T cg22525895 chr1:207977042 MIR29B2 0.4 8.31 0.31 5.96e-16 Schizophrenia; BRCA cis rs910316 1.000 rs10136948 chr14:75511075 C/T cg08847533 chr14:75593920 NEK9 0.92 23.71 0.68 1.28e-89 Height; BRCA cis rs2625529 0.652 rs8040216 chr15:72255249 C/T cg16672083 chr15:72433130 SENP8 0.66 15.65 0.53 6e-47 Red blood cell count; BRCA cis rs13108904 0.901 rs13119532 chr4:1304505 G/C cg00684032 chr4:1343700 KIAA1530 0.38 9.23 0.34 3.82e-19 Obesity-related traits; BRCA cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg13902645 chr11:5959945 NA 0.65 15.23 0.52 6.33e-45 DNA methylation (variation); BRCA cis rs10504229 1.000 rs66870803 chr8:58180022 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs10504229 1.000 rs58947041 chr8:58188934 G/A cg24829409 chr8:58192753 C8orf71 -0.59 -12.27 -0.44 3.13e-31 Developmental language disorder (linguistic errors); BRCA cis rs1129187 0.755 rs13215983 chr6:42924193 C/T cg16590910 chr6:42928470 GNMT 0.36 7.83 0.3 2.11e-14 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg24562669 chr7:97807699 LMTK2 0.45 12.03 0.43 3.58e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs9381107 0.932 rs13198509 chr6:9479610 C/T cg14735645 chr6:9486422 NA -0.46 -8.1 -0.31 2.85e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs7618915 0.547 rs62253733 chr3:52653414 A/G cg18404041 chr3:52824283 ITIH1 -0.43 -12.8 -0.45 1.42e-33 Bipolar disorder; BRCA cis rs7103648 1.000 rs7947450 chr11:47429904 G/A cg20307385 chr11:47447363 PSMC3 0.86 26.38 0.72 2.51e-104 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs6142102 0.625 rs6141436 chr20:32554571 T/A cg24642439 chr20:33292090 TP53INP2 0.39 7.82 0.3 2.22e-14 Skin pigmentation; BRCA cis rs992157 0.698 rs6746089 chr2:219170377 A/G cg00012203 chr2:219082015 ARPC2 0.47 9.11 0.34 1.09e-18 Colorectal cancer; BRCA trans rs2727020 0.521 rs7946190 chr11:49521964 T/A cg03929089 chr4:120376271 NA 0.64 12.62 0.45 9.66e-33 Coronary artery disease; BRCA cis rs72781680 0.784 rs12616678 chr2:24181159 G/T cg08917208 chr2:24149416 ATAD2B 0.62 10.39 0.38 1.76e-23 Lymphocyte counts; BRCA cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.71 14.72 0.5 1.86e-42 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1832871 0.672 rs9457345 chr6:158743098 A/G cg07165851 chr6:158734300 TULP4 0.62 12.46 0.44 4.65e-32 Height; BRCA cis rs4595586 0.545 rs4254106 chr12:39389342 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs3793683 0.556 rs2803989 chr10:134560596 C/T cg27286337 chr10:134555280 INPP5A 0.59 11.33 0.41 3.16e-27 Migraine; BRCA cis rs6912958 0.781 rs4707376 chr6:88270947 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.53 -0.32 1.06e-16 Monocyte percentage of white cells; BRCA cis rs1552244 1.000 rs67569278 chr3:10149893 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.09 0.56 3.46e-54 Alzheimer's disease; BRCA cis rs4566357 0.557 rs2272201 chr2:227912551 T/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.08 -0.3 3.32e-15 Coronary artery disease; BRCA cis rs611744 0.506 rs13280454 chr8:109263240 A/G cg21045802 chr8:109455806 TTC35 0.35 7.89 0.3 1.3e-14 Dupuytren's disease; BRCA cis rs2075371 0.829 rs727202 chr7:133947942 A/G cg11752832 chr7:134001865 SLC35B4 0.5 11.33 0.41 2.92e-27 Mean platelet volume; BRCA cis rs735860 0.726 rs209510 chr6:53202035 T/C cg10236188 chr6:53219634 NA 0.38 7.92 0.3 1.05e-14 Glaucoma; BRCA cis rs2115536 0.730 rs4573897 chr15:80187225 G/A cg02196730 chr15:80188777 MTHFS 0.36 7.95 0.3 8.27e-15 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs9733 0.569 rs11588404 chr1:150688529 C/A cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs11105298 0.891 rs10858879 chr12:89886578 A/T cg00757033 chr12:89920650 WDR51B -0.51 -10.39 -0.38 1.74e-23 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs769267 0.930 rs751856 chr19:19602945 A/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.25 0.34 3.24e-19 Tonsillectomy; BRCA cis rs9818758 0.607 rs11716445 chr3:49406095 C/T cg00383909 chr3:49044727 WDR6 0.89 12.7 0.45 3.96e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs1348850 0.872 rs7559521 chr2:178452328 A/G cg02961200 chr2:178257176 LOC100130691;AGPS -0.43 -8.79 -0.33 1.42e-17 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg23978390 chr7:1156363 C7orf50 0.33 7.98 0.3 6.64e-15 Longevity;Endometriosis; BRCA cis rs2797160 1.000 rs1739380 chr6:126012858 T/C cg05901451 chr6:126070800 HEY2 0.4 9.73 0.36 6.12e-21 Endometrial cancer; BRCA cis rs10504229 1.000 rs66796009 chr8:58174529 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7246657 0.663 rs4803287 chr19:38079435 A/G cg18154014 chr19:37997991 ZNF793 0.5 9.38 0.35 1.11e-19 Coronary artery calcification; BRCA cis rs1008375 0.932 rs11941874 chr4:17666416 C/T cg16339924 chr4:17578868 LAP3 -0.57 -13.28 -0.47 9.97e-36 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs813218 0.584 rs1718240 chr3:99536937 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.4 -8.47 -0.32 1.66e-16 Orofacial clefts; BRCA cis rs17784882 0.524 rs7433300 chr3:47120640 G/A cg16586182 chr3:47516702 SCAP -0.56 -12.53 -0.44 2.3e-32 QT interval; BRCA cis rs72781680 0.800 rs72780112 chr2:23991182 C/T cg08917208 chr2:24149416 ATAD2B 0.89 12.98 0.46 2.32e-34 Lymphocyte counts; BRCA cis rs9649213 0.593 rs2107716 chr7:97944744 G/A cg01877450 chr7:97915802 BRI3 -0.39 -8.97 -0.33 3.34e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -8.98 -0.33 3.09e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4074536 0.574 rs10737732 chr1:116288774 G/A cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs12497850 0.931 rs13064784 chr3:49135961 C/G cg07636037 chr3:49044803 WDR6 0.99 29.67 0.76 2.75e-122 Parkinson's disease; BRCA trans rs2727020 0.894 rs1917328 chr11:49359606 G/A cg03929089 chr4:120376271 NA -0.68 -13.52 -0.47 8.34e-37 Coronary artery disease; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.73 -0.33 2.24e-17 Total body bone mineral density; BRCA cis rs9311474 0.507 rs6787154 chr3:52784416 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.45 0.44 5.41e-32 Electroencephalogram traits; BRCA cis rs1801251 1.000 rs283486 chr2:233644223 A/G cg25237894 chr2:233734115 C2orf82 0.39 11.41 0.41 1.45e-27 Coronary artery disease; BRCA cis rs9287719 0.578 rs7598541 chr2:10700516 G/A cg00105475 chr2:10696890 NA 0.47 10.26 0.38 5.63e-23 Prostate cancer; BRCA cis rs4237845 0.537 rs1599931 chr12:58258850 A/G cg02175503 chr12:58329896 NA 0.45 8.61 0.32 5.56e-17 Intelligence (multi-trait analysis); BRCA cis rs698833 0.710 rs1441048 chr2:44511929 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.46 9.46 0.35 5.9e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2797160 1.000 rs1739367 chr6:126004720 G/T cg05901451 chr6:126070800 HEY2 -0.39 -9.49 -0.35 4.46e-20 Endometrial cancer; BRCA cis rs11122272 0.735 rs2474633 chr1:231486989 A/C cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.49 -11.74 -0.42 6.16e-29 Hemoglobin concentration; BRCA cis rs61931739 0.517 rs2101396 chr12:34048927 T/A cg06521331 chr12:34319734 NA -0.58 -11.65 -0.42 1.47e-28 Morning vs. evening chronotype; BRCA cis rs6570726 0.967 rs9403706 chr6:145795187 C/T cg23711669 chr6:146136114 FBXO30 -0.62 -14.17 -0.49 7.79e-40 Lobe attachment (rater-scored or self-reported); BRCA cis rs17253792 0.822 rs77599953 chr14:56058905 C/T cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs3806843 0.966 rs7710380 chr5:140156264 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.87 -0.36 1.83e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs925228 0.504 rs7568176 chr2:24313758 T/A cg20701182 chr2:24300061 SF3B14 -0.53 -8.56 -0.32 8.43e-17 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs9341808 0.718 rs12208016 chr6:80823563 G/A cg08355045 chr6:80787529 NA 0.37 9.37 0.35 1.24e-19 Sitting height ratio; BRCA cis rs7618915 0.571 rs2251219 chr3:52584787 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.47 -9.47 -0.35 5.18e-20 Bipolar disorder; BRCA cis rs16976116 0.901 rs1061821 chr15:55496111 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4363385 0.747 rs4255332 chr1:152958745 G/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.78 -0.33 1.54e-17 Inflammatory skin disease; BRCA cis rs6582630 0.502 rs10880450 chr12:38440294 G/C cg26384229 chr12:38710491 ALG10B 0.66 15.38 0.52 1.21e-45 Drug-induced liver injury (flucloxacillin); BRCA cis rs8180040 0.966 rs2101247 chr3:47494303 G/A cg16586182 chr3:47516702 SCAP 0.65 15.14 0.51 1.86e-44 Colorectal cancer; BRCA cis rs2624839 0.629 rs2526397 chr3:50187790 A/C cg14019146 chr3:50243930 SLC38A3 0.61 14.96 0.51 1.4e-43 Intelligence (multi-trait analysis); BRCA cis rs12048904 0.505 rs11166511 chr1:101240686 G/C cg16556008 chr1:101360663 SLC30A7;EXTL2 -0.66 -16.69 -0.55 3.67e-52 Multiple sclerosis; BRCA cis rs1008375 0.932 rs7697329 chr4:17657853 C/A cg02297831 chr4:17616191 MED28 0.4 8.67 0.32 3.67e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 -0.62 -13.14 -0.46 4.59e-35 Lymphocyte counts; BRCA cis rs769267 0.930 rs2315022 chr19:19413381 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.66 0.39 1.63e-24 Tonsillectomy; BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs28595532 0.920 rs116023902 chr4:119725131 A/G cg14228332 chr4:119757509 SEC24D 0.68 8.1 0.31 2.78e-15 Cannabis dependence symptom count; BRCA cis rs2742417 0.603 rs2742395 chr3:45758595 A/G cg04837898 chr3:45731254 SACM1L -0.43 -8.66 -0.32 3.79e-17 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs13064411 0.696 rs7613546 chr3:113228019 G/A cg18753928 chr3:113234510 CCDC52 -0.58 -12.18 -0.43 7.72e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs61990749 0.597 rs2112136 chr14:78248952 T/C cg23188588 chr14:78226832 SNW1;C14orf178 0.46 7.83 0.3 2.01e-14 Fibroblast growth factor basic levels; BRCA cis rs360798 0.532 rs13013218 chr2:63011671 C/T cg17519650 chr2:63277830 OTX1 -0.37 -8.24 -0.31 9.75e-16 Coronary artery disease; BRCA cis rs9291683 0.567 rs12499857 chr4:9995376 G/A cg00071950 chr4:10020882 SLC2A9 0.59 14.32 0.49 1.53e-40 Bone mineral density; BRCA cis rs6121246 0.542 rs75694362 chr20:30450708 T/C cg13852791 chr20:30311386 BCL2L1 0.67 8.95 0.33 3.82e-18 Mean corpuscular hemoglobin; BRCA trans rs4596713 0.507 rs10869975 chr9:71795034 C/T cg16512924 chr15:28394682 HERC2 -0.46 -11.14 -0.4 1.79e-26 Headache; BRCA cis rs738322 0.804 rs4821743 chr22:38514906 A/G cg25457927 chr22:38595422 NA -0.31 -10.86 -0.39 2.51e-25 Cutaneous nevi; BRCA cis rs9291683 0.552 rs10939655 chr4:10014642 A/T cg02734326 chr4:10020555 SLC2A9 0.42 9.07 0.34 1.43e-18 Bone mineral density; BRCA cis rs35110281 0.720 rs162372 chr21:44928863 C/T cg01579765 chr21:45077557 HSF2BP 0.41 10.74 0.39 7.46e-25 Mean corpuscular volume; BRCA cis rs977987 0.778 rs1109341 chr16:75445605 G/A cg03315344 chr16:75512273 CHST6 0.52 12.42 0.44 7.05e-32 Dupuytren's disease; BRCA cis rs10883723 0.773 rs11191313 chr10:104278618 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 16.64 0.55 6.55e-52 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7772486 0.790 rs2265469 chr6:146219049 T/C cg23711669 chr6:146136114 FBXO30 0.75 17.42 0.57 6.43e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs12545109 0.800 rs1595940 chr8:57398309 T/C cg09654669 chr8:57350985 NA -0.41 -7.93 -0.3 1e-14 Obesity-related traits; BRCA cis rs12586317 0.586 rs2295103 chr14:35515920 C/G cg16230307 chr14:35515116 FAM177A1 0.72 14.67 0.5 3.48e-42 Psoriasis; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg22907277 chr7:1156413 C7orf50 0.49 10.98 0.4 7.84e-26 Longevity;Endometriosis; BRCA cis rs2839186 0.588 rs7280110 chr21:47619039 G/A cg12379764 chr21:47803548 PCNT 0.39 8.56 0.32 8.18e-17 Testicular germ cell tumor; BRCA cis rs921968 0.541 rs72965126 chr2:219330189 C/T cg02176678 chr2:219576539 TTLL4 -0.51 -12.82 -0.45 1.19e-33 Mean corpuscular hemoglobin concentration; BRCA cis rs1003719 0.680 rs2154537 chr21:38502012 G/C cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.15 -0.49 9.86e-40 Eye color traits; BRCA cis rs10504229 0.953 rs78089850 chr8:58171557 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.06 -0.43 2.48e-30 Developmental language disorder (linguistic errors); BRCA cis rs6446731 0.593 rs7656026 chr4:3273625 G/C cg08886695 chr4:3369023 RGS12 -0.38 -9.89 -0.36 1.49e-21 Mean platelet volume; BRCA cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg03146154 chr1:46216737 IPP -0.5 -11.01 -0.4 6.25e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs875971 1.000 rs1540651 chr7:65650121 C/T cg12463550 chr7:65579703 CRCP -0.38 -8.21 -0.31 1.26e-15 Aortic root size; BRCA cis rs2404602 0.684 rs1011084 chr15:77007480 C/G cg23625390 chr15:77176239 SCAPER -0.55 -13.15 -0.46 4.02e-35 Blood metabolite levels; BRCA cis rs3617 0.598 rs56214994 chr3:52878600 G/C cg11645453 chr3:52864694 ITIH4 -0.38 -9.93 -0.37 1.05e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA trans rs9325144 0.513 rs7977596 chr12:38649067 C/A cg23762105 chr12:34175262 ALG10 0.34 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA trans rs17685 0.712 rs4552844 chr7:75718095 A/G cg19862616 chr7:65841803 NCRNA00174 0.85 28.37 0.75 3.22e-115 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2637266 1.000 rs7080883 chr10:78361200 A/G cg18941641 chr10:78392320 NA 0.35 7.84 0.3 1.83e-14 Pulmonary function; BRCA cis rs11098499 0.863 rs2291185 chr4:120434833 C/A cg09307838 chr4:120376055 NA 0.69 14.07 0.49 2.31e-39 Corneal astigmatism; BRCA trans rs208520 0.789 rs9351549 chr6:66871851 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.98 -19.39 -0.61 3.14e-66 Exhaled nitric oxide output; BRCA cis rs6570726 0.791 rs6923074 chr6:145893332 T/C cg05347473 chr6:146136440 FBXO30 0.39 7.94 0.3 9.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs8103278 1.000 rs8108864 chr19:46301671 G/A cg12641515 chr19:46296257 DMWD -0.55 -12.23 -0.44 4.66e-31 Coronary artery disease; BRCA cis rs9814567 0.752 rs6764764 chr3:134331167 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.51 14.84 0.51 5.07e-43 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9733 0.543 rs72702558 chr1:150683251 G/A cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA cis rs1451375 0.617 rs10267323 chr7:50591424 A/G cg18232548 chr7:50535776 DDC 0.44 9.36 0.35 1.33e-19 Malaria; BRCA cis rs6788895 1.000 rs79709238 chr3:150488477 A/C cg09723797 chr3:150481914 SIAH2 0.71 8.59 0.32 6.53e-17 Breast cancer; BRCA cis rs61931739 0.517 rs11053224 chr12:34484919 G/A cg06521331 chr12:34319734 NA -0.57 -10.68 -0.39 1.32e-24 Morning vs. evening chronotype; BRCA cis rs6120849 0.754 rs7268266 chr20:33581889 T/C cg24642439 chr20:33292090 TP53INP2 0.59 10.18 0.37 1.18e-22 Protein C levels; BRCA cis rs3768617 0.510 rs1413388 chr1:183096694 T/C ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs9300255 0.602 rs10744147 chr12:123643729 A/G cg05973401 chr12:123451056 ABCB9 0.41 7.94 0.3 9.17e-15 Neutrophil percentage of white cells; BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18758796 chr5:131593413 PDLIM4 0.32 8.52 0.32 1.12e-16 Breast cancer; BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg20203395 chr5:56204925 C5orf35 -0.52 -10.92 -0.4 1.42e-25 Initial pursuit acceleration; BRCA cis rs514406 0.679 rs541852 chr1:53256834 A/G cg24675658 chr1:53192096 ZYG11B 0.84 18.94 0.6 7.77e-64 Monocyte count; BRCA cis rs17253792 0.915 rs77252471 chr14:56178075 C/T cg01858014 chr14:56050164 KTN1 -0.67 -8.51 -0.32 1.22e-16 Putamen volume; BRCA cis rs1864400 0.605 rs12360493 chr10:43718613 A/G cg15436174 chr10:43711423 RASGEF1A 0.43 9.06 0.34 1.57e-18 Hirschsprung disease; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.62 -0.42 1.89e-28 Lymphocyte counts; BRCA cis rs10256972 0.521 rs871019 chr7:1105230 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -11.7 -0.42 8.44e-29 Longevity;Endometriosis; BRCA cis rs72781680 1.000 rs72781675 chr2:24232092 G/A cg08917208 chr2:24149416 ATAD2B 1.04 14.64 0.5 4.66e-42 Lymphocyte counts; BRCA cis rs1635 0.655 rs723476 chr6:28305104 C/T cg15743358 chr6:28303923 ZNF323 -0.75 -8.75 -0.33 1.94e-17 Schizophrenia; BRCA cis rs10504229 1.000 rs17805332 chr8:58169798 A/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.26 -0.31 8.5e-16 Developmental language disorder (linguistic errors); BRCA cis rs2236521 0.659 rs72487383 chr20:60889313 A/C cg09594475 chr20:60884601 LAMA5 0.5 11.02 0.4 5.44e-26 Pelvic organ prolapse; BRCA cis rs10791323 0.592 rs2851115 chr11:133705381 C/A cg14349672 chr11:133703707 NA -0.43 -9.62 -0.36 1.56e-20 Childhood ear infection; BRCA cis rs1580019 0.961 rs958217 chr7:32493417 A/G cg07520158 chr7:32535189 LSM5;AVL9 0.37 7.93 0.3 9.7e-15 Cognitive ability; BRCA cis rs6594499 0.872 rs10045255 chr5:110438357 C/T cg04022379 chr5:110408740 TSLP -0.35 -7.97 -0.3 7.07e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6582630 0.555 rs10880520 chr12:38464111 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.88e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs919433 0.680 rs2565160 chr2:198286474 A/G cg00792783 chr2:198669748 PLCL1 0.38 8.52 0.32 1.15e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2637266 0.967 rs7900230 chr10:78366879 A/G cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs68170813 0.559 rs5002976 chr7:107050620 C/G cg02696742 chr7:106810147 HBP1 -0.53 -8.07 -0.3 3.44e-15 Coronary artery disease; BRCA trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg06636001 chr8:8085503 FLJ10661 -0.52 -10.41 -0.38 1.48e-23 Retinal vascular caliber; BRCA cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg11301795 chr4:187892539 NA -0.27 -8.81 -0.33 1.17e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs2243480 1.000 rs781156 chr7:65479141 C/A cg18252515 chr7:66147081 NA -0.88 -12.64 -0.45 7.81e-33 Diabetic kidney disease; BRCA cis rs3806843 0.657 rs2563283 chr5:140105978 C/A cg26395211 chr5:140044315 WDR55 0.37 8.43 0.32 2.36e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs11724804 0.532 rs7657611 chr4:880558 G/C cg20916646 chr4:852691 GAK 0.5 10.99 0.4 7.26e-26 Primary biliary cholangitis;Limited cutaneous systemic scleroderma; BRCA cis rs9287719 0.967 rs2287062 chr2:10743191 G/A cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.38 8.21 0.31 1.24e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg25036284 chr2:26402008 FAM59B 0.9 15.64 0.53 6.69e-47 Gut microbiome composition (summer); BRCA cis rs3793683 0.825 rs3793674 chr10:134555773 C/T cg26818010 chr10:134567672 INPP5A 0.37 8.72 0.33 2.47e-17 Migraine; BRCA cis rs2836950 0.527 rs2836948 chr21:40599677 T/C cg11890956 chr21:40555474 PSMG1 -0.62 -13.82 -0.48 3.3e-38 Menarche (age at onset); BRCA cis rs7949030 0.626 rs71490390 chr11:62329185 A/G cg11742103 chr11:62369870 EML3;MTA2 0.54 13.59 0.47 3.96e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs875971 1.000 rs7789554 chr7:65946038 A/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.27 0.31 7.91e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs4727027 0.901 rs7794500 chr7:148819519 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 -0.4 -9.19 -0.34 5.23e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg02018176 chr4:1364513 KIAA1530 0.38 7.97 0.3 7.33e-15 Longevity; BRCA cis rs7647973 0.710 rs1532204 chr3:49609477 C/G cg07636037 chr3:49044803 WDR6 0.55 8.7 0.33 2.75e-17 Menarche (age at onset); BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.9 0.48 1.45e-38 Alzheimer's disease; BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg11814155 chr7:99998594 ZCWPW1 0.43 8.29 0.31 6.45e-16 Platelet count; BRCA cis rs9393692 0.645 rs9467703 chr6:26318903 A/G cg05868516 chr6:26286170 HIST1H4H 0.41 8.12 0.31 2.45e-15 Educational attainment; BRCA cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg19482086 chr6:160211437 TCP1;MRPL18 0.69 18.03 0.58 4.69e-59 Age-related macular degeneration (geographic atrophy); BRCA cis rs9287719 0.967 rs2024431 chr2:10731327 A/G cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.03e-23 Prostate cancer; BRCA cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg13114125 chr14:105738426 BRF1 0.48 10.55 0.39 4.36e-24 Mean platelet volume;Platelet distribution width; BRCA cis rs9811920 0.609 rs809415 chr3:99582242 G/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.15 0.31 1.99e-15 Axial length; BRCA cis rs79839061 0.518 rs3755961 chr4:895059 A/G cg14530993 chr4:882597 GAK 0.53 9.78 0.36 3.71e-21 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.818 rs61811862 chr1:152995668 G/A cg25856811 chr1:152973957 SPRR3 -0.31 -8.09 -0.3 3.09e-15 Inflammatory skin disease; BRCA cis rs2624839 0.630 rs2624841 chr3:50198415 C/T cg05623727 chr3:50126028 RBM5 0.39 8.52 0.32 1.15e-16 Intelligence (multi-trait analysis); BRCA cis rs17601876 0.814 rs3889391 chr15:51558422 G/A cg19946085 chr15:51559439 CYP19A1 -0.36 -9.84 -0.36 2.31e-21 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs3806843 0.966 rs2563266 chr5:140136915 C/A cg16179182 chr5:140090404 VTRNA1-1 0.43 10.12 0.37 2.05e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs6952808 0.656 rs11764212 chr7:2067593 C/A cg05863683 chr7:1912471 MAD1L1 0.43 9.31 0.35 2.09e-19 Bipolar disorder and schizophrenia; BRCA cis rs4423214 0.840 rs1619577 chr11:71181485 C/T cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.28e-28 Vitamin D levels; BRCA cis rs2637266 1.000 rs12258924 chr10:78364758 G/A cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.18e-14 Pulmonary function; BRCA cis rs875971 0.638 rs6960778 chr7:66071597 C/T cg18876405 chr7:65276391 NA -0.62 -15.33 -0.52 2.13e-45 Aortic root size; BRCA cis rs7829975 0.617 rs4841071 chr8:8791144 G/T cg15556689 chr8:8085844 FLJ10661 0.43 11.74 0.42 5.79e-29 Mood instability; BRCA cis rs698813 0.637 rs7579841 chr2:44498887 T/A cg00619915 chr2:44497795 NA -0.37 -7.9 -0.3 1.26e-14 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs1863824 0.625 rs10887598 chr10:88166160 T/A cg07322936 chr10:88137208 NA -0.47 -9.41 -0.35 8.52e-20 Schizophrenia; BRCA cis rs4819052 0.885 rs28576202 chr21:46674684 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.64 14.0 0.48 4.71e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2303745 0.589 rs751599 chr19:17396549 A/G cg10664184 chr19:17420304 DDA1 0.32 8.96 0.33 3.52e-18 Systemic lupus erythematosus; BRCA cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.54 -0.32 9.95e-17 Monocyte percentage of white cells; BRCA cis rs4363385 0.747 rs1415962 chr1:152958731 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.88 -0.33 6.84e-18 Inflammatory skin disease; BRCA cis rs1215050 0.765 rs1530905 chr4:98805705 A/G cg05340658 chr4:99064831 C4orf37 0.44 10.13 0.37 1.74e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2153535 0.580 rs6914276 chr6:8450435 A/T cg07606381 chr6:8435919 SLC35B3 -0.65 -14.19 -0.49 6.03e-40 Motion sickness; BRCA cis rs7493 1.000 rs2299264 chr7:95046708 C/T cg01874867 chr7:94954059 PON1 -0.4 -8.07 -0.3 3.47e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs6951245 0.580 rs78894484 chr7:1138721 T/G cg13565492 chr6:43139072 SRF -0.89 -16.02 -0.54 8.62e-49 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7246657 0.943 rs1373991 chr19:37838911 T/C cg14683738 chr19:37701593 ZNF585B 0.45 8.02 0.3 4.94e-15 Coronary artery calcification; BRCA cis rs2282526 0.587 rs91424 chr21:44921161 A/G cg04455712 chr21:45112962 RRP1B -0.36 -8.79 -0.33 1.35e-17 Mean corpuscular hemoglobin; BRCA cis rs3733585 0.638 rs7377625 chr4:9953099 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.39 -0.38 1.77e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs600806 0.815 rs4970758 chr1:109979617 A/G cg20591472 chr1:110008990 SYPL2 0.32 7.89 0.3 1.34e-14 Intelligence (multi-trait analysis); BRCA cis rs7020830 0.830 rs308499 chr9:37348059 C/G cg14294708 chr9:37120828 ZCCHC7 1.04 29.82 0.76 4.03e-123 Schizophrenia; BRCA cis rs7246657 0.654 rs10407568 chr19:38123009 A/T cg23950597 chr19:37808831 NA -0.5 -8.59 -0.32 6.86e-17 Coronary artery calcification; BRCA cis rs881375 1.000 rs881375 chr9:123652898 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.66 0.32 3.82e-17 Rheumatoid arthritis; BRCA cis rs6952808 0.792 rs13224989 chr7:1953766 C/G cg04267008 chr7:1944627 MAD1L1 -0.65 -14.46 -0.5 3.2e-41 Bipolar disorder and schizophrenia; BRCA cis rs6570726 0.791 rs9376945 chr6:145828080 T/A cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA trans rs6598955 0.671 rs75517917 chr1:26612926 G/T cg07461501 chr17:79650226 HGS;ARL16 -0.65 -13.64 -0.47 2.41e-37 Obesity-related traits; BRCA cis rs3806843 0.735 rs801180 chr5:140092903 G/T cg26395211 chr5:140044315 WDR55 0.37 8.67 0.32 3.68e-17 Depressive symptoms (multi-trait analysis); BRCA trans rs7824557 0.806 rs10503418 chr8:11118983 C/T cg15556689 chr8:8085844 FLJ10661 -0.41 -10.02 -0.37 4.58e-22 Retinal vascular caliber; BRCA cis rs870825 0.929 rs1405940 chr4:185591481 A/G cg20176042 chr4:185552304 CASP3 -0.6 -8.29 -0.31 6.72e-16 Blood protein levels; BRCA cis rs2549003 0.674 rs960757 chr5:131826310 G/A cg02551604 chr5:131831745 NA -0.4 -14.11 -0.49 1.57e-39 Asthma (sex interaction); BRCA cis rs1005277 0.579 rs2023351 chr10:38378814 A/G cg25427524 chr10:38739819 LOC399744 -0.7 -16.88 -0.56 4.06e-53 Extrinsic epigenetic age acceleration; BRCA cis rs1577917 0.545 rs9344548 chr6:86487337 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.34 9.18 0.34 5.93e-19 Response to antipsychotic treatment; BRCA cis rs2243480 1.000 rs1979823 chr7:65704613 G/A cg18252515 chr7:66147081 NA 1.07 15.89 0.53 3.53e-48 Diabetic kidney disease; BRCA cis rs9649213 0.593 rs10953257 chr7:97960664 A/G cg21770322 chr7:97807741 LMTK2 -0.41 -10.87 -0.39 2.32e-25 Prostate cancer (SNP x SNP interaction); BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.63 10.82 0.39 3.76e-25 Platelet count; BRCA cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg22834771 chr12:69754056 YEATS4 -0.39 -9.64 -0.36 1.29e-20 Blood protein levels; BRCA cis rs2730245 1.000 rs2657345 chr7:158744169 T/C cg24397884 chr7:158709396 WDR60 -0.98 -24.63 -0.7 1.1e-94 Height; BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.6 -11.5 -0.41 5.73e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs72615157 0.697 rs2056726 chr7:99780283 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.61 10.27 0.38 5.12e-23 Lung function (FEV1/FVC); BRCA cis rs17345786 0.861 rs74768235 chr3:101142821 T/C cg12386194 chr3:101231763 SENP7 0.7 13.18 0.46 2.87e-35 Colonoscopy-negative controls vs population controls; BRCA cis rs4689592 0.523 rs3857179 chr4:7070496 T/A cg26116260 chr4:7069785 GRPEL1 0.94 27.52 0.74 1.3800000000000001e-110 Monocyte percentage of white cells; BRCA cis rs6088580 0.524 rs7269596 chr20:33229063 T/C cg08999081 chr20:33150536 PIGU -0.33 -8.66 -0.32 3.94e-17 Glomerular filtration rate (creatinine); BRCA trans rs7824557 0.767 rs2164272 chr8:11162496 A/C cg06636001 chr8:8085503 FLJ10661 0.53 9.99 0.37 6.06e-22 Retinal vascular caliber; BRCA cis rs724568 0.546 rs1367457 chr2:67951861 C/T cg14046302 chr2:67939758 NA 0.38 10.25 0.38 6.56e-23 Major depressive disorder (broad); BRCA cis rs9837602 1.000 rs1688771 chr3:99503359 T/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.59 -10.77 -0.39 5.51e-25 Breast cancer; BRCA cis rs35146811 0.622 rs6946204 chr7:99589125 T/C cg22906224 chr7:99728672 NA 0.46 8.72 0.33 2.31e-17 Coronary artery disease; BRCA cis rs10504229 1.000 rs56255635 chr8:58178264 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs7824557 0.707 rs3808519 chr8:11142970 C/G cg21775007 chr8:11205619 TDH 0.62 12.82 0.45 1.21e-33 Retinal vascular caliber; BRCA cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg18132916 chr6:79620363 NA -0.48 -11.06 -0.4 4.06e-26 Intelligence (multi-trait analysis); BRCA cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg26818010 chr10:134567672 INPP5A -0.66 -14.4 -0.49 6.53e-41 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6546550 0.935 rs13392884 chr2:70036711 A/G cg02498382 chr2:70120550 SNRNP27 -0.49 -10.23 -0.38 7.56e-23 Prevalent atrial fibrillation; BRCA cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg26031613 chr14:104095156 KLC1 0.44 8.7 0.33 2.83e-17 Schizophrenia; BRCA cis rs7044106 0.762 rs1867254 chr9:123429078 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.65 14.13 0.49 1.16e-39 Hip circumference adjusted for BMI; BRCA cis rs8180040 0.966 rs13079098 chr3:47442863 A/G cg27129171 chr3:47204927 SETD2 0.71 17.08 0.56 3.77e-54 Colorectal cancer; BRCA cis rs2073300 0.609 rs6137907 chr20:23344511 C/T cg12062639 chr20:23401060 NAPB 0.94 13.43 0.47 2.23e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs11190604 1.000 rs7079756 chr10:102302105 G/A cg07080220 chr10:102295463 HIF1AN 0.59 13.98 0.48 5.78e-39 Palmitoleic acid (16:1n-7) levels; BRCA cis rs490234 0.966 rs829312 chr9:128377873 C/T cg14078157 chr9:128172775 NA -0.33 -7.95 -0.3 8.25e-15 Mean arterial pressure; BRCA cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg05234568 chr11:5960015 NA -0.52 -10.29 -0.38 4.3e-23 DNA methylation (variation); BRCA cis rs11958404 0.932 rs59246968 chr5:157418180 T/C cg05962755 chr5:157440814 NA 0.47 9.28 0.34 2.58e-19 IgG glycosylation; BRCA cis rs9837602 0.810 rs9854260 chr3:99850212 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 9.32 0.35 1.84e-19 Breast cancer; BRCA cis rs4819052 0.851 rs7276591 chr21:46680156 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.61 13.44 0.47 1.87e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg11644478 chr21:40555479 PSMG1 -0.51 -10.82 -0.39 3.75e-25 Menarche (age at onset); BRCA cis rs490234 0.702 rs10986788 chr9:128303942 G/C cg14078157 chr9:128172775 NA -0.51 -11.39 -0.41 1.73e-27 Mean arterial pressure; BRCA cis rs6963495 0.606 rs6969426 chr7:105147150 G/A cg19920283 chr7:105172520 RINT1 0.58 9.14 0.34 7.99e-19 Bipolar disorder (body mass index interaction); BRCA trans rs4714291 0.925 rs847755 chr6:40030378 T/C cg02267698 chr19:7991119 CTXN1 0.41 7.85 0.3 1.74e-14 Strep throat; BRCA cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg18404041 chr3:52824283 ITIH1 -0.53 -16.39 -0.54 1.19e-50 Bipolar disorder; BRCA cis rs2880765 0.743 rs8032488 chr15:86012768 T/C cg10818794 chr15:86012489 AKAP13 -0.3 -8.26 -0.31 8.35e-16 Coronary artery disease; BRCA cis rs1372520 0.935 rs2245801 chr4:90757840 T/C cg15133208 chr4:90757351 SNCA -0.41 -8.13 -0.31 2.27e-15 Neuroticism; BRCA cis rs3125734 0.633 rs4979774 chr10:63967795 A/T cg09941381 chr10:64027924 RTKN2 -0.28 -8.5 -0.32 1.37e-16 Rheumatoid arthritis; BRCA cis rs2404602 0.684 rs10851888 chr15:76902506 C/T cg23625390 chr15:77176239 SCAPER -0.54 -12.62 -0.45 9.28e-33 Blood metabolite levels; BRCA cis rs155076 1.000 rs155076 chr13:21870114 A/G cg25811766 chr13:21894605 NA -0.55 -9.0 -0.34 2.54e-18 White matter hyperintensity burden; BRCA cis rs7267979 0.932 rs13040655 chr20:25582197 C/T cg08601574 chr20:25228251 PYGB 0.34 7.93 0.3 9.9e-15 Liver enzyme levels (alkaline phosphatase); BRCA trans rs7618501 1.000 rs11130219 chr3:49752427 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.57 -0.39 3.71e-24 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.966 rs4934736 chr10:35496868 G/A cg03585969 chr10:35415529 CREM 0.49 10.38 0.38 2.0500000000000001e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg23711669 chr6:146136114 FBXO30 0.72 16.64 0.55 6.64e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs965469 0.947 rs6051773 chr20:3330382 C/G cg25506879 chr20:3388711 C20orf194 -0.53 -10.5 -0.38 6.58e-24 IFN-related cytopenia; BRCA cis rs10267417 0.557 rs10249101 chr7:19895397 T/G cg05791153 chr7:19748676 TWISTNB 0.45 8.86 0.33 7.98e-18 Night sleep phenotypes; BRCA cis rs13256369 0.802 rs11249885 chr8:8562008 C/T cg18904891 chr8:8559673 CLDN23 0.64 14.35 0.49 1.16e-40 Obesity-related traits; BRCA cis rs780096 0.526 rs1647266 chr2:27693485 T/C cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs6973256 0.583 rs2345943 chr7:133340630 A/G cg07491979 chr7:133331646 EXOC4 -0.36 -8.2 -0.31 1.32e-15 Intelligence (multi-trait analysis); BRCA cis rs490234 0.702 rs4838277 chr9:128367886 C/T cg14078157 chr9:128172775 NA -0.5 -11.06 -0.4 4.01e-26 Mean arterial pressure; BRCA cis rs35110281 0.774 rs141521 chr21:44963686 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -10.15 -0.37 1.55e-22 Mean corpuscular volume; BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg00106254 chr7:1943704 MAD1L1 0.37 10.17 0.37 1.3e-22 Bipolar disorder and schizophrenia; BRCA cis rs2576037 0.796 rs2576043 chr18:44573476 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -8.92 -0.33 4.91e-18 Personality dimensions; BRCA cis rs13046373 0.535 rs8129571 chr21:31980646 G/A cg16812893 chr21:31813075 KRTAP15-1 0.38 9.72 0.36 6.22e-21 HDL cholesterol; BRCA cis rs7552404 0.731 rs10873788 chr1:76367857 A/C cg22875332 chr1:76189707 ACADM 0.57 10.86 0.39 2.56e-25 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg11764359 chr7:65958608 NA -0.75 -17.53 -0.57 1.81e-56 Aortic root size; BRCA cis rs1707322 0.752 rs8179402 chr1:46142466 C/A cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7264396 0.635 rs6060719 chr20:34546013 A/C cg23207816 chr20:34252616 CPNE1;RBM12 0.4 8.38 0.31 3.4e-16 Total cholesterol levels; BRCA cis rs7580658 0.521 rs35577992 chr2:127941324 C/T cg16751203 chr2:127950803 CYP27C1 0.29 8.11 0.31 2.63e-15 Protein C levels; BRCA cis rs2404602 1.000 rs2404602 chr15:77030792 A/G cg22467129 chr15:76604101 ETFA -0.4 -9.09 -0.34 1.28e-18 Blood metabolite levels; BRCA cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.35 -0.35 1.46e-19 Bipolar disorder; BRCA cis rs3925075 1.000 rs4889543 chr16:31340216 C/T cg02846316 chr16:31340340 ITGAM 0.54 13.32 0.47 6.97e-36 IgA nephropathy; BRCA cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg06766960 chr11:133703094 NA 0.61 13.14 0.46 4.29e-35 Childhood ear infection; BRCA cis rs9287719 0.614 rs6711473 chr2:10723374 T/C cg00105475 chr2:10696890 NA 0.41 9.17 0.34 6.17e-19 Prostate cancer; BRCA cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg22535103 chr8:58192502 C8orf71 -0.43 -8.87 -0.33 7.02e-18 Developmental language disorder (linguistic errors); BRCA cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg05234568 chr11:5960015 NA -0.49 -9.68 -0.36 8.89e-21 DNA methylation (variation); BRCA trans rs17685 0.712 rs56965035 chr7:75795670 G/A cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs61931739 0.500 rs9919726 chr12:34510783 A/G cg26384229 chr12:38710491 ALG10B 0.59 13.53 0.47 7.42e-37 Morning vs. evening chronotype; BRCA cis rs796364 0.951 rs12996313 chr2:200997916 C/T cg23649088 chr2:200775458 C2orf69 -0.57 -8.58 -0.32 7.12e-17 Schizophrenia; BRCA cis rs6952808 0.531 rs3800922 chr7:2184505 A/G cg00106254 chr7:1943704 MAD1L1 -0.39 -9.31 -0.35 1.96e-19 Bipolar disorder and schizophrenia; BRCA trans rs7786808 0.530 rs7785656 chr7:158184164 C/G cg02030672 chr11:45687055 CHST1 0.36 7.98 0.3 6.79e-15 Obesity-related traits; BRCA trans rs11088226 0.681 rs11700670 chr21:33938615 T/C cg09050820 chr6:167586206 TCP10L2 0.77 13.24 0.46 1.49e-35 Gastritis; BRCA cis rs4665809 0.590 rs62130493 chr2:26516418 C/T cg04944784 chr2:26401820 FAM59B 1.0 16.5 0.55 3.29e-51 Gut microbiome composition (summer); BRCA cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg19729930 chr2:74357872 NA 0.6 15.01 0.51 7.62e-44 Gestational age at birth (maternal effect); BRCA cis rs7659604 0.728 rs6852923 chr4:122688324 G/A cg06713675 chr4:122721982 EXOSC9 -0.51 -11.56 -0.42 3.49e-28 Type 2 diabetes; BRCA cis rs2836950 0.509 rs11088466 chr21:40580017 T/A cg11644478 chr21:40555479 PSMG1 -0.5 -10.74 -0.39 7.25e-25 Menarche (age at onset); BRCA cis rs736408 0.562 rs13071584 chr3:52804487 T/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.71 -0.42 7.63e-29 Bipolar disorder; BRCA cis rs4481887 0.927 rs10888340 chr1:248440381 C/T cg00666640 chr1:248458726 OR2T12 0.35 9.16 0.34 6.75e-19 Common traits (Other); BRCA cis rs12497850 0.897 rs6446252 chr3:48911125 C/T cg07636037 chr3:49044803 WDR6 0.97 28.36 0.75 3.74e-115 Parkinson's disease; BRCA cis rs7131987 0.621 rs57803026 chr12:29497506 G/A cg09582351 chr12:29534625 ERGIC2 -0.48 -10.85 -0.39 2.8e-25 QT interval; BRCA cis rs798554 0.523 rs1182197 chr7:2863289 A/C cg13628971 chr7:2884303 GNA12 0.4 9.09 0.34 1.25e-18 Height; BRCA cis rs17125944 0.505 rs77690283 chr14:53233320 C/G cg00686598 chr14:53173677 PSMC6 1.17 15.83 0.53 7.63e-48 Alzheimer's disease (late onset); BRCA cis rs9381040 0.626 rs2272986 chr6:41037778 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.27 -0.34 2.9e-19 Alzheimer's disease (late onset); BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.65 -12.21 -0.43 5.68e-31 Gut microbiome composition (summer); BRCA cis rs2549003 0.966 rs2706386 chr5:131832687 C/T cg21138405 chr5:131827807 IRF1 -0.4 -12.91 -0.45 4.83e-34 Asthma (sex interaction); BRCA cis rs10927875 0.541 rs1048245 chr1:16341354 T/G cg06159980 chr1:16340746 HSPB7 -0.39 -8.87 -0.33 7.26e-18 Dilated cardiomyopathy; BRCA cis rs13102973 0.666 rs2042650 chr4:135897082 T/C cg14419869 chr4:135874104 NA -0.46 -9.04 -0.34 1.82e-18 Subjective well-being; BRCA cis rs921968 0.509 rs10932782 chr2:219353195 C/T cg10223061 chr2:219282414 VIL1 -0.27 -7.92 -0.3 1.04e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs1862618 0.853 rs10461617 chr5:56104308 A/G cg24549020 chr5:56110836 MAP3K1 0.59 12.01 0.43 4.38e-30 Initial pursuit acceleration; BRCA cis rs2576037 0.796 rs2576041 chr18:44580919 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.22 0.31 1.13e-15 Personality dimensions; BRCA cis rs2816062 0.813 rs2816053 chr1:18895819 A/G cg18795169 chr1:18902165 NA -0.94 -27.92 -0.74 9.35e-113 Urate levels in lean individuals; BRCA cis rs1552244 1.000 rs17032295 chr3:10086680 C/T cg02579736 chr3:10068473 FANCD2;CIDECP 0.93 19.7 0.61 7.03e-68 Alzheimer's disease; BRCA cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg03433033 chr1:76189801 ACADM 0.75 16.9 0.56 3.13e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs13102973 0.867 rs4543187 chr4:135906850 G/A cg14419869 chr4:135874104 NA 0.45 8.98 0.33 3.05e-18 Subjective well-being; BRCA cis rs651907 0.535 rs11711903 chr3:101500748 C/G cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 13.49 0.47 1.19e-36 Colorectal cancer; BRCA cis rs12950390 0.853 rs66471233 chr17:45867086 C/T cg24803719 chr17:45855879 NA -0.31 -7.99 -0.3 6.54e-15 IgG glycosylation; BRCA cis rs7666738 0.830 rs12233741 chr4:98950296 C/T cg05340658 chr4:99064831 C4orf37 0.68 16.9 0.56 3.04e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs6964833 1.000 rs4717907 chr7:74086493 C/T cg07504079 chr7:72649617 NCF1B -0.5 -10.03 -0.37 4.56e-22 Menarche (age at onset); BRCA cis rs3008870 0.755 rs1024229 chr1:67512903 G/T cg02640540 chr1:67518911 SLC35D1 0.51 11.18 0.4 1.27e-26 Lymphocyte percentage of white cells; BRCA cis rs1355223 0.506 rs7947848 chr11:34866220 T/C cg11058730 chr11:34937778 PDHX;APIP -0.49 -9.5 -0.35 4.21e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs3806843 0.900 rs2563279 chr5:140131535 G/A cg11822812 chr5:140052017 DND1 -0.31 -8.47 -0.32 1.69e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs6782228 0.606 rs2253144 chr3:128329920 C/T cg16766828 chr3:128327626 NA 0.41 9.34 0.35 1.52e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs1577917 0.655 rs9444352 chr6:86257535 G/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A 0.3 8.23 0.31 1.04e-15 Response to antipsychotic treatment; BRCA cis rs2762353 0.806 rs6909187 chr6:25785925 C/T cg12310025 chr6:25882481 NA 0.43 10.63 0.39 2.07e-24 Blood metabolite levels; BRCA cis rs2153535 0.580 rs2184586 chr6:8474182 A/G cg07606381 chr6:8435919 SLC35B3 0.64 14.13 0.49 1.19e-39 Motion sickness; BRCA cis rs7586879 0.616 rs12713422 chr2:25134497 A/C cg01884057 chr2:25150051 NA 0.34 9.12 0.34 9.39e-19 Body mass index; BRCA cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg00321850 chr1:175162397 KIAA0040 -0.41 -11.46 -0.41 9.01e-28 Alcohol dependence; BRCA cis rs7617773 0.817 rs3731513 chr3:48219537 A/G cg11946769 chr3:48343235 NME6 0.68 13.86 0.48 2.3e-38 Coronary artery disease; BRCA cis rs672059 1.000 rs1760621 chr1:183156006 T/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.44 0.32 2.1e-16 Hypertriglyceridemia; BRCA cis rs1862618 0.853 rs252916 chr5:56121788 G/C cg24549020 chr5:56110836 MAP3K1 0.59 12.17 0.43 8.89e-31 Initial pursuit acceleration; BRCA cis rs17604090 1.000 rs67970052 chr7:29655038 C/T cg19413766 chr7:29689036 LOC646762 -0.61 -8.11 -0.31 2.64e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg13047869 chr3:10149882 C3orf24 0.51 10.72 0.39 8.72e-25 Alzheimer's disease; BRCA trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg11707556 chr5:10655725 ANKRD33B -0.44 -11.02 -0.4 5.57e-26 Coronary artery disease; BRCA cis rs2019137 0.539 rs6755040 chr2:113981137 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.66 14.11 0.49 1.57e-39 Lymphocyte counts; BRCA cis rs4689388 0.890 rs11732208 chr4:6292716 G/C cg25554036 chr4:6271136 WFS1 0.42 10.16 0.37 1.35e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.22 0.49 4.64e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg10802521 chr3:52805072 NEK4 -0.33 -8.55 -0.32 8.89e-17 Bipolar disorder; BRCA cis rs1005224 0.853 rs9323616 chr14:76151697 T/C cg04684003 chr14:76127793 TTLL5;C14orf1 -0.35 -8.26 -0.31 8.29e-16 Large artery stroke; BRCA cis rs2204008 0.715 rs12368462 chr12:38336116 C/G cg13010199 chr12:38710504 ALG10B 0.51 10.32 0.38 3.41e-23 Bladder cancer; BRCA cis rs9942416 0.660 rs61173369 chr5:74997995 A/G cg19683494 chr5:74908142 NA 0.46 8.69 0.33 3.05e-17 Age-related disease endophenotypes; BRCA cis rs7617773 0.744 rs2125482 chr3:48323133 T/G cg11946769 chr3:48343235 NME6 0.62 13.25 0.46 1.4e-35 Coronary artery disease; BRCA cis rs10256972 0.567 rs2949185 chr7:1209013 A/G cg26608667 chr7:1196370 ZFAND2A 0.44 10.75 0.39 6.66e-25 Longevity;Endometriosis; BRCA cis rs7666738 1.000 rs2865983 chr4:99033352 C/T cg17366294 chr4:99064904 C4orf37 0.5 11.14 0.4 1.76e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs7809950 0.723 rs62483633 chr7:106876644 T/G cg23024343 chr7:107201750 COG5 -0.47 -9.39 -0.35 1.07e-19 Coronary artery disease; BRCA cis rs4665809 0.887 rs4665825 chr2:26333100 A/G cg27170947 chr2:26402098 FAM59B -0.65 -11.21 -0.41 9.48e-27 Gut microbiome composition (summer); BRCA cis rs9381040 0.610 rs6940356 chr6:41020360 C/T cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.29 -0.34 2.43e-19 Alzheimer's disease (late onset); BRCA cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg07606381 chr6:8435919 SLC35B3 0.66 14.53 0.5 1.47e-41 Motion sickness; BRCA cis rs4363385 0.818 rs561143 chr1:153010734 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA trans rs61931739 0.534 rs1826144 chr12:34094272 A/G cg13010199 chr12:38710504 ALG10B 0.49 9.42 0.35 7.88e-20 Morning vs. evening chronotype; BRCA cis rs2276314 1.000 rs1789513 chr18:33545630 A/G cg19628046 chr18:33552617 C18orf21 -0.57 -11.47 -0.41 8.35e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs477895 0.838 rs35090903 chr11:64000598 C/T cg23719950 chr11:63933701 MACROD1 -0.54 -8.79 -0.33 1.36e-17 Mean platelet volume; BRCA cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg12927641 chr6:109611667 NA -0.38 -9.2 -0.34 5.21e-19 Reticulocyte fraction of red cells; BRCA cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.66 -13.53 -0.47 7.74e-37 Personality dimensions; BRCA cis rs7903847 0.642 rs11817852 chr10:99158426 C/T cg08345082 chr10:99160200 RRP12 -0.31 -8.89 -0.33 6.36e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs1801251 0.929 rs10933409 chr2:233629386 A/G cg08000102 chr2:233561755 GIGYF2 0.63 13.78 0.48 4.93e-38 Coronary artery disease; BRCA trans rs6582630 0.533 rs4103689 chr12:38702980 A/C cg23762105 chr12:34175262 ALG10 -0.4 -9.79 -0.36 3.41e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs9788721 0.630 rs77681598 chr15:78906103 C/A cg06917634 chr15:78832804 PSMA4 -0.54 -11.46 -0.41 8.84e-28 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs4665809 1.000 rs6546766 chr2:26328680 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA cis rs4819052 0.851 rs4819041 chr21:46659955 C/T cg06618935 chr21:46677482 NA -0.36 -8.25 -0.31 9.36e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs897984 0.645 rs58726213 chr16:31044683 A/G cg00531865 chr16:30841666 NA -0.42 -10.03 -0.37 4.42e-22 Dementia with Lewy bodies; BRCA cis rs651907 0.557 rs59596156 chr3:101394217 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.59 16.36 0.54 1.75e-50 Colorectal cancer; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg21747090 chr2:27597821 SNX17 -0.43 -9.4 -0.35 9.48e-20 Total body bone mineral density; BRCA cis rs6088813 0.925 rs4353719 chr20:33977349 G/A cg14752227 chr20:34000481 UQCC -0.43 -9.11 -0.34 1.08e-18 Height; BRCA cis rs763014 1.000 rs763014 chr16:675680 T/C cg08805041 chr16:621841 PIGQ -0.31 -8.37 -0.31 3.53e-16 Height; BRCA cis rs10883723 0.518 rs10786679 chr10:104315667 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.54 14.4 0.5 6.06e-41 Allergic disease (asthma, hay fever or eczema); BRCA cis rs6484504 0.600 rs1323738 chr11:31344898 T/C cg06552810 chr11:31128660 NA 0.39 8.54 0.32 9.97e-17 Red blood cell count; BRCA cis rs477692 0.905 rs693402 chr10:131422882 G/A cg05714579 chr10:131428358 MGMT 0.59 14.72 0.5 1.95e-42 Response to temozolomide; BRCA trans rs6952808 0.792 rs2056480 chr7:1954301 A/G cg04565464 chr8:145669602 NFKBIL2 -0.39 -8.98 -0.33 2.9e-18 Bipolar disorder and schizophrenia; BRCA cis rs6138458 1.000 rs227630 chr20:24913584 A/G cg06937882 chr20:24974362 C20orf3 -0.44 -8.41 -0.32 2.76e-16 Blood protein levels; BRCA cis rs2041840 0.538 rs2372999 chr2:37573587 T/C cg25727520 chr2:37576821 QPCT -0.28 -7.82 -0.3 2.21e-14 Chronic lymphocytic leukemia; BRCA cis rs6444746 1.000 rs4687454 chr3:193491392 C/G cg22553634 chr3:193489233 NA 0.52 8.86 0.33 8.13e-18 Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid); BRCA cis rs10791323 0.604 rs2257010 chr11:133712348 G/A cg14349672 chr11:133703707 NA -0.42 -9.15 -0.34 7.38e-19 Childhood ear infection; BRCA cis rs7737355 1.000 rs27663 chr5:130741438 T/G cg06307176 chr5:131281290 NA -0.48 -9.34 -0.35 1.54e-19 Life satisfaction; BRCA cis rs8028182 0.636 rs8023815 chr15:75814704 G/A cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs3008870 1.000 rs12132068 chr1:67451924 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.99 -22.35 -0.66 3.35e-82 Lymphocyte percentage of white cells; BRCA trans rs12517041 1.000 rs6880744 chr5:23299825 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.44 -8.07 -0.3 3.61e-15 Calcium levels; BRCA cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg01579765 chr21:45077557 HSF2BP -0.41 -11.14 -0.4 1.91e-26 Mean corpuscular volume; BRCA cis rs796364 0.806 rs112486506 chr2:201073947 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -9.39 -0.35 1.03e-19 Schizophrenia; BRCA cis rs7927592 0.830 rs7120635 chr11:68261293 A/G cg20283391 chr11:68216788 NA -0.39 -7.99 -0.3 6.4e-15 Total body bone mineral density; BRCA trans rs6076960 0.811 rs6053960 chr20:6176778 T/C cg17788362 chr6:86352627 SYNCRIP 0.4 8.83 0.33 9.88e-18 Smooth-surface caries; BRCA cis rs2153535 0.541 rs9392222 chr6:8467649 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.42 0.35 7.86e-20 Motion sickness; BRCA cis rs4665809 0.590 rs9309474 chr2:26448830 T/A cg26119090 chr2:26468346 HADHA;HADHB -1.07 -23.75 -0.68 7.01e-90 Gut microbiome composition (summer); BRCA cis rs736408 0.509 rs13083798 chr3:52649748 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.41 9.08 0.34 1.28e-18 Bipolar disorder; BRCA cis rs2688482 0.512 rs3103953 chr3:195520597 G/A cg11598736 chr3:195384522 SDHAP2 -0.69 -12.19 -0.43 6.75e-31 Lung disease severity in cystic fibrosis; BRCA cis rs9443189 0.570 rs504323 chr6:76294965 A/G cg01950844 chr6:76311363 SENP6 -0.73 -10.02 -0.37 4.94e-22 Prostate cancer; BRCA cis rs7666738 0.830 rs28729647 chr4:99059552 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.28e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.901 rs55755815 chr6:79607121 G/T cg18132916 chr6:79620363 NA -0.48 -10.89 -0.4 1.89e-25 Intelligence (multi-trait analysis); BRCA cis rs1401999 0.659 rs4912518 chr3:183752027 C/T cg01324343 chr3:183735012 ABCC5 -0.68 -16.24 -0.54 6.25e-50 Anterior chamber depth; BRCA cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg16434002 chr17:42200994 HDAC5 0.3 8.77 0.33 1.66e-17 Total body bone mineral density; BRCA cis rs7408868 0.908 rs1044006 chr19:15285052 T/C cg14696996 chr19:15285081 NOTCH3 1.0 14.69 0.5 2.67e-42 Pulse pressure; BRCA cis rs1577917 1.000 rs884841 chr6:86680300 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.02 -0.43 3.93e-30 Response to antipsychotic treatment; BRCA cis rs7666738 0.716 rs1426660 chr4:98876792 T/A cg17366294 chr4:99064904 C4orf37 0.42 9.94 0.37 9.99e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs914218 chr21:46698445 G/C cg06618935 chr21:46677482 NA -0.37 -8.01 -0.3 5.27e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4332037 0.707 rs62435130 chr7:1890002 C/T cg23422044 chr7:1970798 MAD1L1 -0.59 -10.64 -0.39 1.88e-24 Bipolar disorder; BRCA cis rs2180341 1.000 rs7453272 chr6:127633959 C/T cg24812749 chr6:127587940 RNF146 -0.82 -16.89 -0.56 3.26e-53 Breast cancer; BRCA cis rs12949688 0.967 rs12451748 chr17:55822171 T/C cg12582317 chr17:55822272 NA 0.32 7.93 0.3 9.97e-15 Schizophrenia; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg21747090 chr2:27597821 SNX17 -0.45 -9.65 -0.36 1.2e-20 Total body bone mineral density; BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg04944784 chr2:26401820 FAM59B -0.95 -16.25 -0.54 5.83e-50 Gut microbiome composition (summer); BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.65 -11.98 -0.43 5.47e-30 Alzheimer's disease; BRCA cis rs2836974 0.644 rs2836981 chr21:40688365 C/T cg06238570 chr21:40685208 BRWD1 -0.46 -9.26 -0.34 3.17e-19 Cognitive function; BRCA cis rs7914558 1.000 rs12780843 chr10:104769335 G/C cg04362960 chr10:104952993 NT5C2 0.43 10.5 0.38 6.62e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA trans rs9325144 0.600 rs61931871 chr12:38829889 G/A cg23762105 chr12:34175262 ALG10 0.37 8.53 0.32 1.08e-16 Morning vs. evening chronotype; BRCA cis rs2033711 0.902 rs4801589 chr19:58953398 C/G cg00825309 chr19:58991885 ZNF446 -0.63 -14.03 -0.49 3.51e-39 Uric acid clearance; BRCA cis rs4908768 0.501 rs1463051 chr1:8596893 A/T cg20416874 chr1:8611966 RERE 0.28 8.31 0.31 5.95e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs2075371 0.933 rs432336 chr7:133949064 A/G cg02659138 chr7:134003124 SLC35B4 0.31 9.68 0.36 8.67e-21 Mean platelet volume; BRCA cis rs3749237 0.964 rs7431078 chr3:49808190 G/A cg07636037 chr3:49044803 WDR6 0.43 8.71 0.33 2.67e-17 Resting heart rate; BRCA cis rs7811142 0.830 rs6955367 chr7:99961194 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 10.74 0.39 7.69e-25 Platelet count; BRCA cis rs9291683 0.609 rs34709913 chr4:10028955 T/C cg02734326 chr4:10020555 SLC2A9 0.39 8.51 0.32 1.21e-16 Bone mineral density; BRCA cis rs6684428 0.706 rs12119904 chr1:56327241 G/T cg11651538 chr1:56320950 NA -0.44 -7.82 -0.3 2.13e-14 Airflow obstruction; BRCA cis rs858239 0.539 rs28716381 chr7:23189015 G/A cg23682824 chr7:23144976 KLHL7 0.42 10.97 0.4 9.04e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs6964587 1.000 rs2106171 chr7:91750450 A/G cg01689657 chr7:91764605 CYP51A1 0.23 8.46 0.32 1.79e-16 Breast cancer; BRCA cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg17173187 chr15:85201210 NMB -0.42 -9.15 -0.34 7.76e-19 Schizophrenia; BRCA cis rs514406 0.893 rs476108 chr1:53317351 C/T cg25767906 chr1:53392781 SCP2 -0.39 -8.79 -0.33 1.41e-17 Monocyte count; BRCA cis rs9486719 1.000 rs3906199 chr6:97049899 C/A cg06623918 chr6:96969491 KIAA0776 -0.76 -13.5 -0.47 1.01e-36 Migraine;Coronary artery disease; BRCA trans rs9858542 0.953 rs12330269 chr3:49513910 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.66 -0.36 1.04e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4820294 0.669 rs12628135 chr22:38065655 A/G cg21798802 chr22:38057573 PDXP 0.31 8.57 0.32 7.9e-17 Fat distribution (HIV); BRCA cis rs6089829 0.926 rs1060491 chr20:61665817 C/A cg03213289 chr20:61660250 NA -0.6 -14.76 -0.5 1.25e-42 Prostate cancer (SNP x SNP interaction); BRCA cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg11890956 chr21:40555474 PSMG1 1.04 29.41 0.76 7.29e-121 Cognitive function; BRCA cis rs4308124 0.679 rs7600458 chr2:111963590 G/C cg04571233 chr2:111982156 NA -0.45 -9.66 -0.36 1.04e-20 Vitiligo; BRCA cis rs4853036 1.000 rs3816491 chr2:70048534 A/G cg02498382 chr2:70120550 SNRNP27 0.47 8.59 0.32 6.42e-17 Colorectal or endometrial cancer; BRCA cis rs1005277 0.579 rs1780133 chr10:38499509 T/C cg25427524 chr10:38739819 LOC399744 -0.73 -18.12 -0.58 1.55e-59 Extrinsic epigenetic age acceleration; BRCA cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.2 -0.34 5.04e-19 Bipolar disorder; BRCA cis rs875971 1.000 rs1182882 chr7:65562063 C/T cg11764359 chr7:65958608 NA -0.77 -18.03 -0.58 4.5e-59 Aortic root size; BRCA cis rs17270561 0.609 rs3922842 chr6:25736564 T/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs2075371 0.966 rs722657 chr7:133994956 T/C cg02659138 chr7:134003124 SLC35B4 0.34 10.79 0.39 4.94e-25 Mean platelet volume; BRCA cis rs941873 0.868 rs7332 chr10:81114060 G/A cg08514558 chr10:81106712 PPIF 0.4 9.23 0.34 4e-19 Height; BRCA cis rs2624839 0.704 rs14321 chr3:50226151 T/C cg24110177 chr3:50126178 RBM5 0.47 12.11 0.43 1.5e-30 Intelligence (multi-trait analysis); BRCA cis rs11711311 0.955 rs9881563 chr3:113414031 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 -0.4 -10.46 -0.38 9.6e-24 IgG glycosylation; BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg00149659 chr3:10157352 C3orf10 0.71 12.33 0.44 1.69e-31 Alzheimer's disease; BRCA cis rs1401999 0.714 rs13066518 chr3:183635498 T/A cg01324343 chr3:183735012 ABCC5 0.66 15.71 0.53 2.76e-47 Anterior chamber depth; BRCA cis rs61931739 0.500 rs7303318 chr12:34467789 T/C cg06521331 chr12:34319734 NA -0.52 -10.18 -0.37 1.21e-22 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg11814155 chr7:99998594 ZCWPW1 0.44 8.23 0.31 1.09e-15 Platelet count; BRCA cis rs7772486 0.776 rs2265467 chr6:146218339 T/A cg23711669 chr6:146136114 FBXO30 0.67 15.48 0.52 3.8e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs7264396 0.513 rs3787169 chr20:34419884 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.63 -10.78 -0.39 5.15e-25 Total cholesterol levels; BRCA cis rs13256369 0.950 rs13270006 chr8:8574197 C/A cg18904891 chr8:8559673 CLDN23 0.59 11.51 0.41 5.28e-28 Obesity-related traits; BRCA trans rs35110281 0.748 rs2838322 chr21:44998615 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.21 0.37 8.72e-23 Mean corpuscular volume; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs769267 0.930 rs10419912 chr19:19597055 A/G cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -9.23 -0.34 3.84e-19 Tonsillectomy; BRCA cis rs7666738 0.830 rs13144771 chr4:99026935 G/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs35110281 0.782 rs2838329 chr21:45023329 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.49 10.48 0.38 8.14e-24 Mean corpuscular volume; BRCA cis rs1267303 0.675 rs2476164 chr1:46985274 T/C cg25110126 chr1:46999211 NA -0.51 -9.76 -0.36 4.73e-21 Monobrow; BRCA cis rs12545109 0.800 rs2670028 chr8:57423673 G/A cg09654669 chr8:57350985 NA -0.39 -8.21 -0.31 1.18e-15 Obesity-related traits; BRCA trans rs11098499 0.775 rs67281037 chr4:120281157 G/C cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs10870270 0.956 rs67378218 chr10:133752420 A/C cg17892150 chr10:133769511 PPP2R2D -0.73 -16.03 -0.54 7.41e-49 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs4975616 0.836 rs421629 chr5:1320136 G/A cg26373071 chr5:1325741 CLPTM1L 0.48 11.26 0.41 5.98e-27 Lung cancer; BRCA cis rs3862030 0.720 rs11595149 chr10:104235978 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.43 -12.84 -0.45 1.02e-33 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs1003719 0.715 rs2835647 chr21:38546773 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs2625529 0.627 rs11858015 chr15:72552492 G/A cg16672083 chr15:72433130 SENP8 -0.83 -17.14 -0.56 1.84e-54 Red blood cell count; BRCA cis rs11229555 1.000 rs12799215 chr11:58405674 C/T cg15696309 chr11:58395628 NA -0.52 -11.51 -0.41 5.29e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.34 -0.35 1.55e-19 Menopause (age at onset); BRCA cis rs1468333 1.000 rs3777113 chr5:137493897 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.42 8.95 0.33 3.79e-18 Resting heart rate; BRCA cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08109568 chr15:31115862 NA -0.45 -10.66 -0.39 1.62e-24 Huntington's disease progression; BRCA cis rs67311347 1.000 rs2276871 chr3:40499273 C/T cg09455208 chr3:40491958 NA 0.47 11.39 0.41 1.72e-27 Renal cell carcinoma; BRCA trans rs3942852 0.915 rs905477 chr11:48148606 T/C cg03929089 chr4:120376271 NA -0.45 -8.28 -0.31 7.16e-16 Acute lymphoblastic leukemia (childhood); BRCA cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg17420585 chr12:42539391 GXYLT1 -0.38 -8.06 -0.3 3.77e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs208520 0.690 rs2208442 chr6:66867004 T/C cg07460842 chr6:66804631 NA -1.0 -19.52 -0.61 6.74e-67 Exhaled nitric oxide output; BRCA cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs2303745 0.589 rs11086065 chr19:17395003 A/G cg04248312 chr19:17393744 ANKLE1 -0.93 -21.66 -0.65 1.9e-78 Systemic lupus erythematosus; BRCA cis rs7267979 0.934 rs2261753 chr20:25262291 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.81 0.36 2.92e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7666738 0.861 rs13139309 chr4:99020916 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs4595586 0.545 rs7294600 chr12:39373416 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs2070433 0.500 rs2070435 chr21:47961711 C/T cg12379764 chr21:47803548 PCNT 0.46 10.16 0.37 1.39e-22 Lymphocyte counts; BRCA cis rs1218582 0.741 rs7544528 chr1:154844585 C/T cg24250549 chr1:154909240 PMVK 0.65 16.41 0.54 9.35e-51 Prostate cancer; BRCA cis rs9486715 1.000 rs9486725 chr6:97061159 C/T cg06623918 chr6:96969491 KIAA0776 -0.88 -24.29 -0.69 8.24e-93 Headache; BRCA cis rs4555082 0.834 rs2816624 chr14:105733909 A/G cg13114125 chr14:105738426 BRF1 -0.53 -11.07 -0.4 3.42e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs9420 0.961 rs11605731 chr11:57524089 C/G cg19752551 chr11:57585705 CTNND1 -0.51 -12.58 -0.45 1.37e-32 Schizophrenia; BRCA cis rs10740039 0.768 rs10761549 chr10:62461660 A/G cg02922035 chr10:62493342 NA 0.42 8.05 0.3 4.06e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs992157 0.560 rs12992937 chr2:219087072 A/T cg00012203 chr2:219082015 ARPC2 -0.57 -12.03 -0.43 3.43e-30 Colorectal cancer; BRCA cis rs2070488 1.000 rs13074160 chr3:38455650 G/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.71 19.55 0.61 4.35e-67 Electrocardiographic conduction measures; BRCA cis rs924607 0.583 rs12516251 chr5:608939 C/T cg07001201 chr5:642380 CEP72 0.44 9.18 0.34 5.95e-19 Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia; BRCA cis rs7072216 0.763 rs10883090 chr10:100167236 G/C cg26618903 chr10:100175079 PYROXD2 -0.31 -8.97 -0.33 3.17e-18 Metabolite levels; BRCA cis rs7811142 1.000 rs73161762 chr7:100014846 C/T cg00814883 chr7:100076585 TSC22D4 -0.55 -10.6 -0.39 2.8e-24 Platelet count; BRCA cis rs7618915 0.547 rs11130311 chr3:52675005 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.35 -0.44 1.36e-31 Bipolar disorder; BRCA cis rs7772486 0.754 rs13214277 chr6:146136125 G/T cg05347473 chr6:146136440 FBXO30 0.46 9.03 0.34 2.02e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg24829409 chr8:58192753 C8orf71 -0.57 -11.79 -0.42 3.6e-29 Developmental language disorder (linguistic errors); BRCA cis rs7178424 0.870 rs8034914 chr15:62250430 C/T cg00456672 chr15:62358751 C2CD4A 0.42 9.74 0.36 5.61e-21 Height; BRCA cis rs7412746 0.611 rs4319334 chr1:150766822 G/A cg18016565 chr1:150552671 MCL1 0.33 7.89 0.3 1.35e-14 Melanoma; BRCA cis rs875971 0.862 rs13226170 chr7:65999298 G/A cg11764359 chr7:65958608 NA 0.76 16.83 0.55 7.34e-53 Aortic root size; BRCA cis rs9400271 0.609 rs9386783 chr6:109588644 G/T cg01475377 chr6:109611718 NA -0.44 -10.41 -0.38 1.56e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs4908768 0.501 rs4351668 chr1:8535818 C/T cg20416874 chr1:8611966 RERE -0.29 -8.31 -0.31 5.55e-16 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs736408 0.609 rs13082208 chr3:52781539 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.81 0.39 4.08e-25 Bipolar disorder; BRCA cis rs2762353 0.935 rs11754288 chr6:25776949 G/A cg03264133 chr6:25882463 NA 0.49 10.99 0.4 7.69e-26 Blood metabolite levels; BRCA cis rs7246967 0.673 rs12985495 chr19:22930378 A/G cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 11.17 0.4 1.43e-26 Platelet count; BRCA cis rs765787 0.530 rs2413785 chr15:45530381 T/C cg24006582 chr15:45444508 DUOX1 -0.53 -11.02 -0.4 5.69e-26 Uric acid levels; BRCA cis rs3749237 1.000 rs11710675 chr3:49751900 C/A cg03060546 chr3:49711283 APEH 0.46 9.79 0.36 3.46e-21 Resting heart rate; BRCA cis rs6964587 1.000 rs17164263 chr7:91581566 T/A cg01689657 chr7:91764605 CYP51A1 -0.22 -7.85 -0.3 1.74e-14 Breast cancer; BRCA cis rs2070488 0.775 rs9838614 chr3:38537671 A/C cg24069376 chr3:38537580 EXOG -0.3 -8.45 -0.32 2.04e-16 Electrocardiographic conduction measures; BRCA cis rs7598759 0.548 rs11686485 chr2:232360697 C/T cg19187155 chr2:232395269 NMUR1 0.7 16.92 0.56 2.48e-53 Noise-induced hearing loss; BRCA cis rs2404602 0.716 rs17363713 chr15:76746128 G/C cg22467129 chr15:76604101 ETFA -0.49 -10.67 -0.39 1.44e-24 Blood metabolite levels; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg26608667 chr7:1196370 ZFAND2A 0.41 9.95 0.37 8.43e-22 Longevity;Endometriosis; BRCA cis rs4319547 0.774 rs7954006 chr12:123131824 A/C cg05707623 chr12:122985044 ZCCHC8 0.41 8.51 0.32 1.21e-16 Body mass index; BRCA cis rs17711722 0.503 rs453835 chr7:65511159 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.62 -13.43 -0.47 2.13e-36 Calcium levels; BRCA trans rs4650994 0.544 rs6682815 chr1:178501109 T/C cg05059571 chr16:84539110 KIAA1609 -0.48 -10.89 -0.4 1.93e-25 HDL cholesterol levels;HDL cholesterol; BRCA trans rs1493916 0.837 rs1493908 chr18:31411700 G/A cg27147174 chr7:100797783 AP1S1 -0.42 -8.52 -0.32 1.17e-16 Life satisfaction; BRCA cis rs2635047 0.967 rs2571001 chr18:44665083 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 8.31 0.31 5.63e-16 Educational attainment; BRCA cis rs11605924 0.819 rs12805422 chr11:45839889 G/A ch.11.939596F chr11:45881766 CRY2 -0.44 -9.65 -0.36 1.15e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs35306767 0.855 rs12771179 chr10:872347 A/G cg10556349 chr10:835070 NA 0.73 9.88 0.36 1.6e-21 Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs13134819 chr4:98919885 G/C cg05340658 chr4:99064831 C4orf37 0.65 16.05 0.54 5.84e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs67478160 0.643 rs4906369 chr14:104242458 T/C cg26031613 chr14:104095156 KLC1 -0.43 -8.59 -0.32 6.54e-17 Schizophrenia; BRCA cis rs586533 0.881 rs683623 chr11:99501419 C/G cg22878054 chr11:99397252 CNTN5 0.32 8.11 0.31 2.53e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs763121 0.853 rs138702 chr22:39132601 A/T cg06022373 chr22:39101656 GTPBP1 -0.72 -17.71 -0.57 2.2e-57 Menopause (age at onset); BRCA cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg26031613 chr14:104095156 KLC1 1.01 27.75 0.74 8.32e-112 Body mass index; BRCA cis rs507080 0.922 rs525485 chr11:118555754 C/T cg08498647 chr11:118550644 TREH -0.38 -8.31 -0.31 5.6e-16 Serum metabolite levels; BRCA cis rs6700896 0.931 rs1938498 chr1:66098653 T/C cg04111102 chr1:66153794 NA 0.33 8.23 0.31 1.04e-15 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs7772486 0.790 rs2814880 chr6:146208937 T/G cg23711669 chr6:146136114 FBXO30 0.75 17.32 0.57 2.29e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.534 rs11053010 chr12:34093228 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.09 0.49 1.77e-39 Morning vs. evening chronotype; BRCA cis rs7615952 0.641 rs12487875 chr3:125787224 C/A cg18479299 chr3:125709523 NA -0.54 -8.39 -0.32 3.1e-16 Blood pressure (smoking interaction); BRCA cis rs7904368 0.754 rs17139234 chr10:16849732 G/T cg23933602 chr10:16859644 RSU1 0.6 9.18 0.34 6.14e-19 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg10950524 chr7:2139216 MAD1L1 0.27 7.88 0.3 1.42e-14 Schizophrenia; BRCA cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg11366901 chr6:160182831 ACAT2 0.78 14.99 0.51 9.39e-44 Age-related macular degeneration (geographic atrophy); BRCA cis rs873946 0.586 rs12776770 chr10:134564831 T/C cg18305652 chr10:134549665 INPP5A 0.49 12.09 0.43 1.83e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2839186 0.584 rs2032111 chr21:47904569 G/A cg12379764 chr21:47803548 PCNT -0.41 -8.84 -0.33 9.51e-18 Testicular germ cell tumor; BRCA cis rs365132 0.818 rs251843 chr5:176476106 A/G cg16309518 chr5:176445507 NA -0.39 -9.6 -0.35 1.85e-20 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs16867321 0.639 rs13028421 chr2:181444035 G/T cg23363182 chr2:181467187 NA 0.47 10.26 0.38 5.8e-23 Obesity; BRCA cis rs7586879 0.575 rs6721750 chr2:25128719 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.3e-28 Body mass index; BRCA cis rs4803468 1.000 rs284663 chr19:41932612 C/T cg09537434 chr19:41945824 ATP5SL -1.02 -23.73 -0.68 9.65e-90 Height; BRCA cis rs7959452 0.868 rs12812860 chr12:69746671 T/C cg20891283 chr12:69753455 YEATS4 0.56 13.64 0.47 2.38e-37 Blood protein levels; BRCA cis rs4409675 0.548 rs1000432 chr1:28225119 T/C cg23691781 chr1:28212827 C1orf38 0.32 10.66 0.39 1.53e-24 Corneal astigmatism; BRCA cis rs6748734 1.000 rs3936203 chr2:241834654 C/T cg02820040 chr2:241836501 C2orf54 0.52 9.99 0.37 6.42e-22 Urinary metabolites; BRCA trans rs801193 0.761 rs2659888 chr7:66230171 T/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.39 8.48 0.32 1.56e-16 Aortic root size; BRCA cis rs7666738 0.830 rs6832568 chr4:98994061 G/A cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA trans rs6598955 0.671 rs11247910 chr1:26645666 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.12 -0.51 2.31e-44 Obesity-related traits; BRCA cis rs10465746 0.780 rs1952065 chr1:84464205 T/C cg10977910 chr1:84465055 TTLL7 0.57 11.85 0.42 1.95e-29 Obesity-related traits; BRCA cis rs9487051 1.000 rs9487048 chr6:109615603 G/T cg21918786 chr6:109611834 NA -0.44 -11.88 -0.43 1.46e-29 Reticulocyte fraction of red cells; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg04267008 chr7:1944627 MAD1L1 -0.63 -13.48 -0.47 1.21e-36 Bipolar disorder and schizophrenia; BRCA cis rs7267979 1.000 rs10966 chr20:25282944 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.45 0.35 6.14e-20 Liver enzyme levels (alkaline phosphatase); BRCA trans rs7615952 0.515 rs7637246 chr3:125678706 A/G cg07211511 chr3:129823064 LOC729375 -0.54 -9.57 -0.35 2.35e-20 Blood pressure (smoking interaction); BRCA cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg12310025 chr6:25882481 NA -0.41 -9.68 -0.36 9.32e-21 Height; BRCA cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs2882667 0.858 rs11948429 chr5:138458584 G/A cg04439458 chr5:138467593 SIL1 -0.41 -10.51 -0.38 6.16e-24 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3768617 0.510 rs10752899 chr1:183081241 T/G ch.1.3577855R chr1:183094577 LAMC1 0.68 17.96 0.58 1.14e-58 Fuchs's corneal dystrophy; BRCA cis rs634534 0.591 rs688862 chr11:65733393 A/G cg26695010 chr11:65641043 EFEMP2 -0.35 -8.37 -0.31 3.6e-16 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs11190604 1.000 rs2495760 chr10:102318771 T/C cg07080220 chr10:102295463 HIF1AN 0.63 13.16 0.46 3.59e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs17376456 1.000 rs56046246 chr5:93531545 T/G cg21475434 chr5:93447410 FAM172A 0.72 9.19 0.34 5.29e-19 Diabetic retinopathy; BRCA cis rs3925075 1.000 rs4506917 chr16:31347350 T/G cg02846316 chr16:31340340 ITGAM 0.54 13.29 0.47 9.24e-36 IgA nephropathy; BRCA trans rs7613875 0.620 rs2526747 chr3:50082914 C/G cg21659725 chr3:3221576 CRBN 0.36 8.69 0.33 2.94e-17 Body mass index; BRCA cis rs1843834 0.539 rs2047135 chr2:225427302 G/C cg22509189 chr2:225307070 NA -0.46 -9.84 -0.36 2.31e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs870825 0.929 rs55880126 chr4:185591237 T/G cg04058563 chr4:185651563 MLF1IP 0.88 14.47 0.5 3.03e-41 Blood protein levels; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg20007245 chr22:24372913 LOC391322 0.5 10.69 0.39 1.16e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs2153535 0.580 rs9328478 chr6:8519183 A/G cg21535247 chr6:8435926 SLC35B3 0.41 9.36 0.35 1.36e-19 Motion sickness; BRCA cis rs7772486 0.790 rs9376971 chr6:146259505 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.85 -0.3 1.74e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs17376456 0.569 rs7736892 chr5:93205597 G/A cg25358565 chr5:93447407 FAM172A -0.65 -11.23 -0.41 7.98e-27 Diabetic retinopathy; BRCA cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg25019033 chr10:957182 NA -0.41 -7.9 -0.3 1.25e-14 Eosinophil percentage of granulocytes; BRCA trans rs208520 0.690 rs1233103 chr6:66855943 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.02 -21.31 -0.64 1.47e-76 Exhaled nitric oxide output; BRCA cis rs17253792 0.822 rs76264681 chr14:56060447 T/C cg01858014 chr14:56050164 KTN1 -0.75 -10.35 -0.38 2.64e-23 Putamen volume; BRCA cis rs2304069 0.913 rs9324637 chr5:149390947 T/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.83 16.74 0.55 1.95e-52 HIV-1 control; BRCA cis rs2346177 0.846 rs62138876 chr2:46650672 C/A cg02822958 chr2:46747628 ATP6V1E2 0.4 8.25 0.31 9.27e-16 HDL cholesterol; BRCA cis rs9682041 0.627 rs4955722 chr3:170102959 G/T cg11886554 chr3:170076028 SKIL 0.51 10.13 0.37 1.76e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs16958440 0.867 rs59217333 chr18:44694844 A/C cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs2153535 0.580 rs6597318 chr6:8437289 G/A cg07606381 chr6:8435919 SLC35B3 0.67 14.77 0.5 1.1e-42 Motion sickness; BRCA cis rs365132 0.967 rs11740768 chr5:176339499 G/A cg16309518 chr5:176445507 NA -0.52 -13.34 -0.47 5.56e-36 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs7903847 0.642 rs11189177 chr10:99141663 C/T cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs2011503 1.000 rs6511031 chr19:19471506 T/C cg11584989 chr19:19387371 SF4 -0.6 -13.51 -0.47 9.58e-37 Bipolar disorder; BRCA cis rs7772486 0.597 rs6570732 chr6:146245151 G/A cg13319975 chr6:146136371 FBXO30 0.61 13.98 0.48 6.18e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs17641971 0.599 rs2385230 chr8:50015755 A/G cg00325661 chr8:49890786 NA 0.35 9.96 0.37 7.87e-22 Blood metabolite levels; BRCA cis rs9341808 0.718 rs2143887 chr6:80917287 T/C cg08355045 chr6:80787529 NA 0.39 9.98 0.37 6.58e-22 Sitting height ratio; BRCA cis rs10751667 1.000 rs7396366 chr11:986185 C/A cg01483505 chr11:975446 AP2A2 0.35 9.42 0.35 8.01e-20 Alzheimer's disease (late onset); BRCA cis rs7647973 0.588 rs4855848 chr3:49653457 C/T cg07636037 chr3:49044803 WDR6 0.5 8.23 0.31 1.02e-15 Menarche (age at onset); BRCA cis rs4965272 1.000 rs4965274 chr15:100584971 G/T cg27344315 chr15:100560801 ADAMTS17 0.38 8.16 0.31 1.76e-15 Gastroesophageal reflux disease; BRCA cis rs10461617 0.617 rs6874733 chr5:56069600 A/G cg22800045 chr5:56110881 MAP3K1 0.52 10.07 0.37 3.19e-22 Type 2 diabetes; BRCA cis rs7615952 0.641 rs12491577 chr3:125731131 C/T cg15145296 chr3:125709740 NA -0.56 -8.92 -0.33 5.06e-18 Blood pressure (smoking interaction); BRCA trans rs561341 1.000 rs72821971 chr17:30269343 T/G cg27661571 chr11:113659931 NA -0.83 -12.3 -0.44 2.31e-31 Hip circumference adjusted for BMI; BRCA cis rs7560272 0.501 rs2272178 chr2:73977609 C/T cg20560298 chr2:73613845 ALMS1 0.35 8.96 0.33 3.56e-18 Schizophrenia; BRCA cis rs2842992 0.830 rs1853259 chr6:160147441 A/G cg19482086 chr6:160211437 TCP1;MRPL18 -0.66 -16.84 -0.55 6.09e-53 Age-related macular degeneration (geographic atrophy); BRCA cis rs826838 0.900 rs1403523 chr12:39130570 T/A cg26384229 chr12:38710491 ALG10B -0.62 -16.22 -0.54 7.9e-50 Heart rate; BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.76 -11.47 -0.41 8.06e-28 Platelet count; BRCA trans rs11098499 0.754 rs2964 chr4:120240131 T/C cg25214090 chr10:38739885 LOC399744 0.44 10.29 0.38 4.34e-23 Corneal astigmatism; BRCA cis rs11758351 1.000 rs79264785 chr6:26194121 C/T cg01420254 chr6:26195488 NA 0.59 9.16 0.34 6.84e-19 Gout;Renal underexcretion gout; BRCA cis rs2204008 0.744 rs11514358 chr12:38255526 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Bladder cancer; BRCA cis rs11229555 0.609 rs12286421 chr11:58174898 A/G cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2839186 0.771 rs2280957 chr21:47642272 A/G cg05896524 chr21:47604654 C21orf56 -0.49 -9.65 -0.36 1.19e-20 Testicular germ cell tumor; BRCA cis rs7605378 1.000 rs796363 chr2:200693668 T/C cg23649088 chr2:200775458 C2orf69 0.48 9.65 0.36 1.13e-20 Osteoporosis; BRCA cis rs9462027 0.628 rs9469891 chr6:34767396 A/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 1.98e-14 Systemic lupus erythematosus; BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.75 -12.95 -0.46 3.01e-34 Platelet count; BRCA cis rs8141529 0.702 rs8137262 chr22:29292135 C/T cg02153584 chr22:29168773 CCDC117 0.51 10.69 0.39 1.14e-24 Lymphocyte counts; BRCA cis rs6840360 0.571 rs4696278 chr4:152558978 A/G cg22705602 chr4:152727874 NA -0.33 -8.32 -0.31 5.25e-16 Intelligence (multi-trait analysis); BRCA cis rs27434 0.583 rs34756 chr5:96152383 C/T cg16492584 chr5:96139282 ERAP1 0.49 12.3 0.44 2.34e-31 Ankylosing spondylitis; BRCA cis rs7607369 0.536 rs6436091 chr2:219669141 T/C cg02176678 chr2:219576539 TTLL4 -0.38 -10.16 -0.37 1.45e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs6570726 0.755 rs451699 chr6:145830594 C/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.39 -0.35 1e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs4689592 0.513 rs2358718 chr4:7068743 A/C cg07817883 chr1:32538562 TMEM39B 0.46 8.58 0.32 7.17e-17 Monocyte percentage of white cells; BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg26314531 chr2:26401878 FAM59B 0.61 10.65 0.39 1.68e-24 Gut microbiome composition (summer); BRCA cis rs6582630 0.594 rs7308707 chr12:38450428 G/C cg26384229 chr12:38710491 ALG10B -0.43 -9.84 -0.36 2.2e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs2204008 0.582 rs11179135 chr12:38204689 A/C cg26384229 chr12:38710491 ALG10B 0.75 16.26 0.54 5.37e-50 Bladder cancer; BRCA trans rs57221529 0.766 rs72703042 chr5:579269 C/T cg25482853 chr8:67687455 SGK3 1.05 16.94 0.56 1.94e-53 Lung disease severity in cystic fibrosis; BRCA cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00475322 chr7:917719 C7orf20 0.45 11.51 0.41 5.37e-28 Perceived unattractiveness to mosquitoes; BRCA cis rs7945705 0.905 rs2568054 chr11:8876029 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.61 -14.56 -0.5 1.07e-41 Hemoglobin concentration; BRCA cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg22875332 chr1:76189707 ACADM 0.68 14.38 0.49 7.71e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9682041 0.808 rs9880558 chr3:170067771 A/G cg11886554 chr3:170076028 SKIL -0.61 -11.92 -0.43 1.04e-29 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs936229 0.690 rs2445618 chr15:75035256 T/C cg10253484 chr15:75165896 SCAMP2 -0.51 -9.68 -0.36 9.16e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA trans rs4714291 0.963 rs1721411 chr6:40102390 T/G cg02267698 chr19:7991119 CTXN1 0.42 8.24 0.31 9.61e-16 Strep throat; BRCA cis rs1577917 0.837 rs806529 chr6:86467121 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.45 -12.28 -0.44 2.76e-31 Response to antipsychotic treatment; BRCA cis rs9325144 0.534 rs4882283 chr12:38710249 C/T cg13010199 chr12:38710504 ALG10B 0.37 8.81 0.33 1.19e-17 Morning vs. evening chronotype; BRCA cis rs2625529 0.730 rs6494975 chr15:72177825 T/A cg16672083 chr15:72433130 SENP8 0.69 16.34 0.54 2e-50 Red blood cell count; BRCA cis rs2204008 0.627 rs1851117 chr12:38398987 G/T cg13010199 chr12:38710504 ALG10B 0.5 10.22 0.37 8.43e-23 Bladder cancer; BRCA trans rs453301 0.624 rs330049 chr8:9087299 C/T cg08975724 chr8:8085496 FLJ10661 0.39 8.47 0.32 1.65e-16 Joint mobility (Beighton score); BRCA cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.71 -16.63 -0.55 7.03e-52 Axial length; BRCA cis rs1865760 0.534 rs72834629 chr6:26023032 C/T cg17691542 chr6:26056736 HIST1H1C 0.67 13.75 0.48 7.21e-38 Height; BRCA cis rs1707322 1.000 rs4134387 chr1:46395158 A/T cg06784218 chr1:46089804 CCDC17 0.49 11.56 0.42 3.44e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12477438 0.784 rs13407840 chr2:99569928 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.47 -0.52 4.17e-46 Chronic sinus infection; BRCA cis rs2836974 0.568 rs2142111 chr21:40549289 G/C cg17971929 chr21:40555470 PSMG1 0.6 13.8 0.48 4.09e-38 Cognitive function; BRCA cis rs782590 0.967 rs782588 chr2:55841640 T/C cg18811423 chr2:55921094 PNPT1 0.72 22.78 0.67 1.58e-84 Metabolic syndrome; BRCA cis rs7267979 1.000 rs6107046 chr20:25442049 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.5 0.32 1.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs34779708 0.966 rs1213392 chr10:35430285 C/T cg03585969 chr10:35415529 CREM 0.46 9.71 0.36 7.1e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1595825 0.891 rs73054808 chr2:198602283 C/T cg19156104 chr2:198669113 PLCL1 -0.44 -8.02 -0.3 5.18e-15 Ulcerative colitis; BRCA cis rs4665809 0.877 rs35224700 chr2:26298037 T/C cg22920501 chr2:26401640 FAM59B 0.75 10.79 0.39 4.93e-25 Gut microbiome composition (summer); BRCA cis rs10504229 0.683 rs16921831 chr8:58111142 G/A cg08219700 chr8:58056026 NA 0.45 8.16 0.31 1.77e-15 Developmental language disorder (linguistic errors); BRCA cis rs8058578 0.943 rs35629860 chr16:30671532 G/A cg02466173 chr16:30829666 NA -0.49 -10.03 -0.37 4.33e-22 Multiple myeloma; BRCA cis rs9399135 0.967 rs2150681 chr6:135375232 A/G cg24558204 chr6:135376177 HBS1L -0.46 -12.57 -0.45 1.53e-32 Red blood cell count; BRCA trans rs11039798 0.614 rs11039954 chr11:48741818 A/G cg15704280 chr7:45808275 SEPT13 0.59 8.85 0.33 8.61e-18 Axial length; BRCA cis rs5167 0.504 rs7246900 chr19:45454236 G/A cg20090143 chr19:45452003 APOC2 0.27 7.94 0.3 8.85e-15 Blood protein levels; BRCA cis rs6433895 0.710 rs56692685 chr2:182012093 A/G cg00481216 chr2:181971175 NA 0.42 7.96 0.3 7.8e-15 Lymphocyte counts; BRCA cis rs2153535 0.580 rs9405390 chr6:8466209 T/G cg07606381 chr6:8435919 SLC35B3 0.64 14.15 0.49 1.01e-39 Motion sickness; BRCA cis rs10463316 0.894 rs7707745 chr5:150765198 G/T cg03212797 chr5:150827313 SLC36A1 -0.4 -8.07 -0.3 3.43e-15 Metabolite levels (Pyroglutamine); BRCA trans rs2204008 0.660 rs2874343 chr12:38239096 C/T cg06521331 chr12:34319734 NA -0.52 -9.41 -0.35 8.45e-20 Bladder cancer; BRCA cis rs13118159 0.550 rs28614045 chr4:1374695 C/A cg16405210 chr4:1374714 KIAA1530 -0.91 -22.88 -0.67 4.49e-85 Longevity; BRCA cis rs2370759 1.000 rs77165999 chr10:32577131 T/C cg18270830 chr10:32634957 EPC1 0.58 10.03 0.37 4.37e-22 Sexual dysfunction (female); BRCA cis rs12762955 0.561 rs10752022 chr10:1043798 C/T cg18964960 chr10:1102726 WDR37 -0.51 -9.13 -0.34 8.55e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs17401966 0.931 rs17410217 chr1:10371854 A/G cg03954927 chr1:10346856 KIF1B 0.48 14.9 0.51 2.64e-43 Hepatocellular carcinoma; BRCA cis rs801193 1.000 rs62466794 chr7:66191579 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 8.11 0.31 2.68e-15 Aortic root size; BRCA cis rs1691799 0.867 rs1183274 chr12:66732057 C/G cg16791601 chr12:66731901 HELB -0.65 -17.57 -0.57 1.16e-56 White blood cell count (basophil); BRCA cis rs7246657 0.525 rs1667357 chr19:37484352 T/C cg23950597 chr19:37808831 NA -0.52 -8.28 -0.31 7.37e-16 Coronary artery calcification; BRCA cis rs10504229 0.683 rs11774847 chr8:58140775 T/A cg08219700 chr8:58056026 NA 0.61 9.75 0.36 4.97e-21 Developmental language disorder (linguistic errors); BRCA cis rs1129187 0.755 rs9471976 chr6:42920549 G/T cg10862848 chr6:42927986 GNMT -0.36 -15.05 -0.51 5.11e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2576037 0.523 rs1539881 chr18:44477897 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.65 0.5 4.14e-42 Personality dimensions; BRCA trans rs6479891 0.818 rs9299455 chr10:65073601 A/G cg14819942 chr15:35414228 NA -0.34 -8.43 -0.32 2.36e-16 Arthritis (juvenile idiopathic); BRCA cis rs2242116 0.761 rs6780601 chr3:46965856 A/G cg16586182 chr3:47516702 SCAP -0.44 -8.9 -0.33 5.79e-18 Birth weight; BRCA cis rs9393777 0.513 rs11967852 chr6:26612870 G/T cg12826209 chr6:26865740 GUSBL1 0.6 10.45 0.38 1.09e-23 Intelligence (multi-trait analysis); BRCA cis rs6938 0.534 rs8025447 chr15:75192222 T/G cg10253484 chr15:75165896 SCAMP2 -0.55 -11.5 -0.41 5.72e-28 Breast cancer; BRCA cis rs10504229 0.683 rs6984765 chr8:58127124 T/C cg22535103 chr8:58192502 C8orf71 -0.45 -8.97 -0.33 3.26e-18 Developmental language disorder (linguistic errors); BRCA cis rs4819052 0.851 rs2838837 chr21:46665988 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 9.99 0.37 6.19e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11690935 0.959 rs10206062 chr2:172577276 A/T cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.88 -0.77 8.37e-129 Schizophrenia; BRCA cis rs3796352 1.000 rs11712653 chr3:53070875 A/C cg07884673 chr3:53033167 SFMBT1 -0.73 -9.95 -0.37 9.05e-22 Immune reponse to smallpox (secreted IL-2); BRCA cis rs7246657 1.000 rs7246657 chr19:37747108 C/T cg18154014 chr19:37997991 ZNF793 -0.48 -9.06 -0.34 1.6e-18 Coronary artery calcification; BRCA cis rs12142240 0.698 rs17361763 chr1:46810670 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.5e-19 Menopause (age at onset); BRCA cis rs1865721 1.000 rs7244787 chr18:73195162 T/C cg26385618 chr18:73139727 C18orf62 -0.39 -8.98 -0.33 2.9e-18 Intelligence; BRCA cis rs3771570 0.901 rs9052 chr2:242434809 G/T cg21155796 chr2:242212141 HDLBP 0.45 7.85 0.3 1.77e-14 Prostate cancer; BRCA cis rs7246657 0.943 rs10404920 chr19:37881556 T/C cg23950597 chr19:37808831 NA -0.72 -12.64 -0.45 7.28e-33 Coronary artery calcification; BRCA cis rs208520 1.000 rs208521 chr6:66953625 C/T cg07460842 chr6:66804631 NA -0.86 -14.26 -0.49 2.84e-40 Exhaled nitric oxide output; BRCA cis rs853679 0.517 rs9295758 chr6:28120663 C/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Depression; BRCA cis rs12701220 0.503 rs12702024 chr7:1129820 G/C cg02733842 chr7:1102375 C7orf50 -0.83 -13.95 -0.48 8.85e-39 Bronchopulmonary dysplasia; BRCA cis rs3820928 0.935 rs12151597 chr2:227859224 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.3 -0.31 6e-16 Pulmonary function; BRCA cis rs9560113 1.000 rs60374273 chr13:112179206 A/T cg10483660 chr13:112241077 NA 0.31 7.84 0.3 1.91e-14 Menarche (age at onset); BRCA trans rs11098499 0.754 rs7672372 chr4:120248406 A/G cg25214090 chr10:38739885 LOC399744 0.45 10.28 0.38 4.68e-23 Corneal astigmatism; BRCA cis rs8177179 0.967 rs6782434 chr3:133438834 C/G cg16262614 chr3:133464971 TF 0.25 7.99 0.3 6.32e-15 Iron status biomarkers (transferrin levels); BRCA cis rs11622475 1.000 rs1187446 chr14:104409896 C/T cg12183467 chr14:104352244 NA -0.51 -10.6 -0.39 2.67e-24 Bipolar disorder; BRCA cis rs523522 0.962 rs4766966 chr12:120942911 G/C cg12219531 chr12:120966889 COQ5 0.53 11.53 0.42 4.47e-28 High light scatter reticulocyte count; BRCA cis rs35110281 0.667 rs4819287 chr21:45120147 A/G cg01579765 chr21:45077557 HSF2BP -0.4 -9.99 -0.37 6.41e-22 Mean corpuscular volume; BRCA cis rs9527 0.615 rs10883804 chr10:104706520 G/A cg04362960 chr10:104952993 NT5C2 0.45 10.44 0.38 1.2e-23 Arsenic metabolism; BRCA cis rs17641971 0.783 rs2385127 chr8:49975746 C/T cg00325661 chr8:49890786 NA 0.32 8.61 0.32 5.74e-17 Blood metabolite levels; BRCA cis rs941873 0.838 rs2233713 chr10:81107135 A/C cg08514558 chr10:81106712 PPIF 0.41 9.48 0.35 4.71e-20 Height; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.0 -0.34 2.59e-18 Menopause (age at onset); BRCA cis rs600806 0.751 rs1933182 chr1:109999838 A/C cg20591472 chr1:110008990 SYPL2 0.33 8.3 0.31 6.14e-16 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.633 rs7628058 chr3:50039474 C/T cg24110177 chr3:50126178 RBM5 -0.36 -9.67 -0.36 9.69e-21 Intelligence (multi-trait analysis); BRCA trans rs931812 0.757 rs4734015 chr8:101909258 C/G cg20993868 chr7:22813445 NA 0.44 13.3 0.47 8.67e-36 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs7586879 0.616 rs10206196 chr2:25137323 T/C cg01884057 chr2:25150051 NA 0.32 8.52 0.32 1.17e-16 Body mass index; BRCA cis rs7666738 0.822 rs6815312 chr4:99058220 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.5e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 1.000 rs55719896 chr16:28846866 G/A cg09754948 chr16:28834200 ATXN2L 0.47 9.17 0.34 6.53e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7772486 0.754 rs6910790 chr6:146255330 G/A cg23711669 chr6:146136114 FBXO30 -0.76 -17.6 -0.57 8.28e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs3099143 1.000 rs3110378 chr15:77127983 G/A cg21673338 chr15:77095150 SCAPER -0.53 -9.51 -0.35 3.9e-20 Recalcitrant atopic dermatitis; BRCA cis rs72781680 0.800 rs56398785 chr2:24091515 T/A cg20701182 chr2:24300061 SF3B14 0.66 9.71 0.36 7.01e-21 Lymphocyte counts; BRCA cis rs826838 0.967 rs1684411 chr12:39128494 C/T cg13010199 chr12:38710504 ALG10B -0.44 -10.19 -0.37 1.09e-22 Heart rate; BRCA cis rs6840360 0.615 rs7695412 chr4:152488075 A/G cg22705602 chr4:152727874 NA -0.31 -8.01 -0.3 5.64e-15 Intelligence (multi-trait analysis); BRCA cis rs13102973 1.000 rs4401503 chr4:135905125 G/A cg14419869 chr4:135874104 NA 0.47 9.71 0.36 7.1e-21 Subjective well-being; BRCA cis rs694739 0.628 rs617051 chr11:64133638 C/A cg02228329 chr11:64053129 BAD;GPR137 0.54 11.88 0.43 1.45e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs13191362 0.935 rs13215748 chr6:163010710 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.52 9.01 0.34 2.33e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs17125944 0.505 rs74620173 chr14:53194068 G/T cg13660082 chr14:53194042 PSMC6 -0.59 -9.26 -0.34 3.18e-19 Alzheimer's disease (late onset); BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg22920501 chr2:26401640 FAM59B -0.81 -13.14 -0.46 4.44e-35 Gut microbiome composition (summer); BRCA trans rs11039798 0.588 rs6485891 chr11:48612024 T/A cg03929089 chr4:120376271 NA 0.49 8.08 0.3 3.31e-15 Axial length; BRCA cis rs9814567 0.806 rs1880375 chr3:134322163 C/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.49 -0.32 1.4e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2404602 0.716 rs7179142 chr15:76698268 G/A cg26408565 chr15:76604113 ETFA -0.47 -10.15 -0.37 1.51e-22 Blood metabolite levels; BRCA cis rs1534166 0.601 rs13324779 chr3:133510413 G/A cg11941060 chr3:133502564 NA 0.33 7.84 0.3 1.84e-14 Alcohol consumption (transferrin glycosylation); BRCA cis rs10791323 0.604 rs2853115 chr11:133707908 C/T cg14349672 chr11:133703707 NA 0.4 9.13 0.34 8.86e-19 Childhood ear infection; BRCA cis rs2882667 0.652 rs700622 chr5:138098551 T/C cg04439458 chr5:138467593 SIL1 0.34 8.41 0.32 2.59e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7811142 0.830 rs77861211 chr7:99962096 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.8 -13.29 -0.47 9.55e-36 Platelet count; BRCA trans rs7618501 0.932 rs4855850 chr3:49761571 G/A cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.46 -0.38 9.46e-24 Intelligence (multi-trait analysis); BRCA cis rs10189230 0.904 rs13029372 chr2:222348434 A/G cg14652038 chr2:222343519 EPHA4 0.48 13.28 0.47 1.03e-35 Urate levels in lean individuals; BRCA cis rs6831352 0.918 rs13110764 chr4:100062466 C/T cg13256891 chr4:100009986 ADH5 -0.53 -9.98 -0.37 6.61e-22 Alcohol dependence; BRCA cis rs796364 0.951 rs2881593 chr2:201000347 A/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.49 -8.91 -0.33 5.32e-18 Schizophrenia; BRCA cis rs9596863 1.000 rs7995218 chr13:54427874 C/G ch.13.53330881F chr13:54432880 NA 0.52 7.93 0.3 1.01e-14 Epilepsy and lamotrigine-induced maculopapular eruptions; BRCA cis rs9649213 0.593 rs736753 chr7:97931489 G/T cg01877450 chr7:97915802 BRI3 -0.37 -8.57 -0.32 7.96e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1801251 1.000 rs67013068 chr2:233608253 G/C cg25237894 chr2:233734115 C2orf82 0.39 11.45 0.41 9.43e-28 Coronary artery disease; BRCA cis rs7737355 0.755 rs12519233 chr5:130960093 C/A cg06307176 chr5:131281290 NA 0.52 10.22 0.37 8.24e-23 Life satisfaction; BRCA cis rs6484504 0.625 rs6484501 chr11:31373100 G/T cg14844989 chr11:31128820 NA 0.46 9.59 0.35 1.88e-20 Red blood cell count; BRCA cis rs6952808 0.965 rs4719318 chr7:1887930 G/A cg14004847 chr7:1930337 MAD1L1 -0.4 -7.91 -0.3 1.15e-14 Bipolar disorder and schizophrenia; BRCA cis rs6545883 0.894 rs6734628 chr2:61451260 T/C cg15711740 chr2:61764176 XPO1 0.5 12.07 0.43 2.36e-30 Tuberculosis; BRCA cis rs7666738 0.830 rs13139078 chr4:99020774 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg24101359 chr6:42928495 GNMT 0.53 12.25 0.44 4.05e-31 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1949733 0.701 rs2631754 chr4:8449233 A/G cg11789530 chr4:8429930 ACOX3 0.59 14.56 0.5 1.07e-41 Response to antineoplastic agents; BRCA cis rs2011503 1.000 rs11670687 chr19:19621752 A/G cg11584989 chr19:19387371 SF4 0.63 13.46 0.47 1.53e-36 Bipolar disorder; BRCA cis rs6701037 0.714 rs2285219 chr1:175130983 A/T cg17845761 chr1:175162550 KIAA0040 -0.26 -9.71 -0.36 6.87e-21 Alcohol dependence; BRCA cis rs763014 0.966 rs4984903 chr16:680695 A/G cg07343612 chr16:622815 PIGQ -0.67 -21.31 -0.64 1.52e-76 Height; BRCA cis rs12618769 0.597 rs3754884 chr2:99125376 C/T cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs7975161 0.630 rs4964257 chr12:104633262 T/C cg25273343 chr12:104657179 TXNRD1 -0.61 -9.53 -0.35 3.31e-20 Toenail selenium levels; BRCA cis rs752010 0.695 rs10890156 chr1:42108090 T/C cg06885757 chr1:42089581 HIVEP3 0.22 8.19 0.31 1.44e-15 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs7811142 1.000 rs7811142 chr7:100065443 A/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.81 0.33 1.19e-17 Platelet count; BRCA cis rs2836974 0.627 rs7278985 chr21:40653767 C/T cg11644478 chr21:40555479 PSMG1 -0.68 -15.35 -0.52 1.74e-45 Cognitive function; BRCA cis rs16854884 0.837 rs7644767 chr3:143803092 C/G cg06585982 chr3:143692056 C3orf58 0.39 7.82 0.3 2.23e-14 Economic and political preferences (feminism/equality); BRCA cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg07606381 chr6:8435919 SLC35B3 0.64 14.19 0.49 6.63e-40 Motion sickness; BRCA cis rs1862618 0.853 rs33322 chr5:56175226 A/G cg20203395 chr5:56204925 C5orf35 -0.49 -9.91 -0.36 1.25e-21 Initial pursuit acceleration; BRCA cis rs4363385 0.747 rs4255332 chr1:152958745 G/C cg24667326 chr1:152973720 SPRR3 -0.33 -9.29 -0.34 2.45e-19 Inflammatory skin disease; BRCA cis rs13046373 0.507 rs2832969 chr21:32019627 A/G cg06468780 chr21:31798236 KRTAP13-3 0.34 8.41 0.32 2.77e-16 HDL cholesterol; BRCA cis rs477895 0.713 rs11607165 chr11:63963947 T/G cg04317338 chr11:64019027 PLCB3 0.55 9.51 0.35 3.67e-20 Mean platelet volume; BRCA cis rs2742234 0.666 rs715106 chr10:43616751 C/A cg02780029 chr10:43622663 RET -0.37 -8.28 -0.31 7.47e-16 Hirschsprung disease; BRCA cis rs1712517 0.835 rs2506961 chr10:105007926 G/T cg05636881 chr10:105038444 INA -0.39 -9.04 -0.34 1.83e-18 Migraine; BRCA cis rs7666738 0.830 rs1534318 chr4:98965058 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.12e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.683 rs113492050 chr8:58130046 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs6724607 1.000 rs13006708 chr2:191471428 G/A cg27211696 chr2:191398769 TMEM194B -0.47 -10.74 -0.39 7.67e-25 Pulse pressure; BRCA cis rs7267979 0.903 rs2500423 chr20:25374882 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12760731 0.565 rs12403070 chr1:178094429 A/G cg00404053 chr1:178313656 RASAL2 0.66 8.07 0.3 3.41e-15 Obesity-related traits; BRCA cis rs7575873 1 rs7575873 chr2:23962647 A/G cg08917208 chr2:24149416 ATAD2B 1.07 14.55 0.5 1.2e-41 Birth weight; BRCA cis rs13191362 1.000 rs13204013 chr6:163002480 T/A cg21926612 chr6:163149169 PACRG;PARK2 0.85 13.4 0.47 2.88e-36 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg11663144 chr21:46675770 NA -0.64 -15.2 -0.52 8.76e-45 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs13108904 0.539 rs13135102 chr4:1330983 A/C cg01939980 chr4:1354348 KIAA1530 0.38 9.2 0.34 5.04e-19 Obesity-related traits; BRCA cis rs13046373 0.505 rs2832962 chr21:32008332 T/C cg24082983 chr21:31802169 KRTAP13-4 0.33 8.26 0.31 8.49e-16 HDL cholesterol; BRCA cis rs9388451 0.626 rs7748729 chr6:126077381 C/T cg05901451 chr6:126070800 HEY2 -0.55 -14.74 -0.5 1.6e-42 Brugada syndrome; BRCA cis rs7659604 0.840 rs6821305 chr4:122713863 A/C cg20573242 chr4:122745356 CCNA2 0.42 10.34 0.38 2.87e-23 Type 2 diabetes; BRCA cis rs8062405 0.691 rs743590 chr16:28608230 G/A cg16576597 chr16:28551801 NUPR1 0.32 8.64 0.32 4.6e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs17376456 0.569 rs6881815 chr5:93105666 A/G cg25358565 chr5:93447407 FAM172A 0.69 12.04 0.43 3.26e-30 Diabetic retinopathy; BRCA cis rs735860 0.712 rs6909592 chr6:53163090 C/G cg10236188 chr6:53219634 NA 0.4 8.61 0.32 5.5e-17 Glaucoma; BRCA cis rs2637266 1.000 rs2395387 chr10:78357029 T/C cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs637571 0.522 rs649000 chr11:65742933 T/C cg02427764 chr11:65769310 BANF1;EIF1AD 0.62 13.69 0.48 1.37e-37 Eosinophil percentage of white cells; BRCA cis rs599083 0.530 rs689179 chr11:68179166 A/G cg01657329 chr11:68192670 LRP5 0.36 8.13 0.31 2.27e-15 Bone mineral density (spine); BRCA cis rs9527 0.637 rs11191424 chr10:104625886 G/A cg04362960 chr10:104952993 NT5C2 0.42 9.92 0.37 1.16e-21 Arsenic metabolism; BRCA cis rs2797160 1.000 rs1739376 chr6:126012084 C/G cg05901451 chr6:126070800 HEY2 0.38 9.28 0.34 2.56e-19 Endometrial cancer; BRCA cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.32 -0.31 5.2e-16 Aortic root size; BRCA cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg23583168 chr7:148888333 NA 0.78 19.25 0.61 1.84e-65 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs6582630 0.519 rs7294300 chr12:38277359 C/A cg06521331 chr12:34319734 NA -0.52 -9.45 -0.35 6.17e-20 Drug-induced liver injury (flucloxacillin); BRCA trans rs12310956 0.532 rs1352210 chr12:33983187 A/G cg26384229 chr12:38710491 ALG10B 0.47 10.43 0.38 1.26e-23 Morning vs. evening chronotype; BRCA cis rs6964587 1.000 rs2961020 chr7:91573308 G/A cg01689657 chr7:91764605 CYP51A1 -0.23 -8.23 -0.31 1.05e-15 Breast cancer; BRCA trans rs57221529 0.766 rs56216231 chr5:581193 G/A cg08313168 chr12:7315531 NA 0.5 8.04 0.3 4.5e-15 Lung disease severity in cystic fibrosis; BRCA trans rs6479891 1.000 rs6479894 chr10:65098741 T/C cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs911119 1.000 rs6114208 chr20:23621734 C/G cg16589663 chr20:23618590 CST3 0.47 8.83 0.33 1.02e-17 Chronic kidney disease; BRCA cis rs17095355 0.818 rs12573187 chr10:111856077 G/A cg00817464 chr10:111662876 XPNPEP1 -0.42 -8.78 -0.33 1.54e-17 Biliary atresia; BRCA cis rs4948102 0.691 rs10435504 chr7:56059591 G/C cg09872392 chr7:56161020 PHKG1 -0.4 -9.08 -0.34 1.39e-18 Plasma homocysteine levels (post-methionine load test); BRCA cis rs4988958 0.565 rs6732138 chr2:103009662 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.21e-16 Asthma (childhood onset); BRCA cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.22 0.41 8.79e-27 Bipolar disorder; BRCA cis rs30380 0.587 rs151940 chr5:96147777 T/C cg16492584 chr5:96139282 ERAP1 -0.47 -10.84 -0.39 3.14e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs6461049 0.765 rs3800908 chr7:2159437 C/T cg21782813 chr7:2030301 MAD1L1 0.31 8.91 0.33 5.44e-18 Schizophrenia; BRCA trans rs208520 0.837 rs208467 chr6:66914837 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.48 -0.55 3.88e-51 Exhaled nitric oxide output; BRCA cis rs10504073 0.669 rs62507253 chr8:50028836 C/T cg00325661 chr8:49890786 NA 0.44 12.11 0.43 1.6e-30 Blood metabolite ratios; BRCA cis rs896854 0.714 rs572547 chr8:95966286 A/G cg13393036 chr8:95962371 TP53INP1 0.34 8.32 0.31 5.28e-16 Type 2 diabetes; BRCA cis rs9649213 0.593 rs6955647 chr7:98004562 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.55 0.42 3.55e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs9443645 0.901 rs6912683 chr6:79543492 C/A cg05283184 chr6:79620031 NA -0.44 -11.2 -0.41 1.07e-26 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.521 rs2352984 chr3:49948728 T/C cg05623727 chr3:50126028 RBM5 0.48 11.85 0.42 2.06e-29 Intelligence (multi-trait analysis); BRCA cis rs7582180 0.663 rs930374 chr2:100962700 A/G cg14675211 chr2:100938903 LONRF2 0.45 10.19 0.37 1.06e-22 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs79561699 chr8:58170601 A/G cg24829409 chr8:58192753 C8orf71 -0.59 -12.09 -0.43 1.97e-30 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.846 rs9815222 chr3:160994897 C/T cg04691961 chr3:161091175 C3orf57 -0.42 -10.26 -0.38 5.91e-23 Morning vs. evening chronotype; BRCA cis rs10267417 0.589 rs6960989 chr7:19869349 G/A cg05791153 chr7:19748676 TWISTNB 0.51 9.75 0.36 5.1e-21 Night sleep phenotypes; BRCA cis rs769267 0.895 rs2965183 chr19:19545696 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.71 0.42 8.19e-29 Tonsillectomy; BRCA cis rs7586879 0.598 rs6545806 chr2:25124348 G/A cg01884057 chr2:25150051 NA 0.36 9.45 0.35 6.38e-20 Body mass index; BRCA cis rs1552244 0.872 rs6803517 chr3:10065426 C/T cg00166722 chr3:10149974 C3orf24 0.6 12.19 0.43 6.74e-31 Alzheimer's disease; BRCA cis rs4727027 0.865 rs13236754 chr7:148845773 G/A cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 8.8 0.33 1.28e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs875971 1.000 rs1565531 chr7:65663113 T/A cg18876405 chr7:65276391 NA -0.55 -13.26 -0.46 1.29e-35 Aortic root size; BRCA cis rs780096 0.526 rs72819536 chr2:27682850 G/T cg12648201 chr2:27665141 KRTCAP3 -0.33 -7.96 -0.3 8.15e-15 Total body bone mineral density; BRCA cis rs7772486 0.597 rs6912351 chr6:146264071 T/C cg13319975 chr6:146136371 FBXO30 0.61 13.93 0.48 1.09e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs694739 0.930 rs574087 chr11:64102948 A/G cg26898376 chr11:64110657 CCDC88B 0.39 8.24 0.31 9.99e-16 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs832540 0.556 rs4146565 chr5:56093825 T/C cg24549020 chr5:56110836 MAP3K1 0.4 8.43 0.32 2.32e-16 Coronary artery disease; BRCA cis rs4268898 0.662 rs17733015 chr2:24509370 A/G cg06627628 chr2:24431161 ITSN2 -0.79 -14.97 -0.51 1.26e-43 Asthma; BRCA cis rs11083475 0.714 rs7248584 chr19:39258110 C/T cg07403899 chr19:39283540 NA -0.23 -7.86 -0.3 1.68e-14 Heart rate; BRCA cis rs703842 1.000 rs703842 chr12:58162739 C/T cg00677455 chr12:58241039 CTDSP2 -0.6 -14.99 -0.51 9.76e-44 Multiple sclerosis; BRCA cis rs7819412 0.521 rs10110684 chr8:11039159 G/C cg21775007 chr8:11205619 TDH -0.51 -10.24 -0.38 6.79e-23 Triglycerides; BRCA cis rs4642101 0.765 rs6791647 chr3:12826425 C/T cg24848339 chr3:12840334 CAND2 -0.44 -11.49 -0.41 6.57e-28 QRS complex (12-leadsum); BRCA cis rs2276314 0.857 rs28396546 chr18:33639024 T/C cg05985134 chr18:33552581 C18orf21 0.64 11.75 0.42 5.31e-29 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg00024416 chr22:24240387 NA 0.34 8.48 0.32 1.51e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6835098 1.000 rs1054497 chr4:174089048 A/T cg08422745 chr4:174089978 GALNT7 0.81 18.13 0.58 1.34e-59 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs739401 0.611 rs3782069 chr11:3033275 G/A cg25174290 chr11:3078921 CARS 0.44 13.09 0.46 7.09e-35 Longevity; BRCA cis rs1552244 0.810 rs6809572 chr3:10100145 G/A cg00149659 chr3:10157352 C3orf10 0.79 13.66 0.48 1.77e-37 Alzheimer's disease; BRCA cis rs2014572 0.933 rs8109882 chr19:57755618 C/G cg24459738 chr19:57751996 ZNF805 -0.34 -8.09 -0.3 2.94e-15 Hyperactive-impulsive symptoms; BRCA cis rs4363385 0.747 rs4323653 chr1:152983359 T/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.17 -0.34 6.54e-19 Inflammatory skin disease; BRCA cis rs7666738 0.830 rs1967977 chr4:98966141 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7072216 0.763 rs733345 chr10:100164215 G/T cg26618903 chr10:100175079 PYROXD2 -0.29 -8.5 -0.32 1.38e-16 Metabolite levels; BRCA cis rs11676348 0.755 rs6436026 chr2:218951738 T/A cg00012203 chr2:219082015 ARPC2 -0.41 -7.88 -0.3 1.4e-14 Ulcerative colitis; BRCA cis rs10504073 0.584 rs7818507 chr8:49918423 G/T cg00325661 chr8:49890786 NA 0.47 13.78 0.48 4.99e-38 Blood metabolite ratios; BRCA cis rs4665809 0.590 rs7579504 chr2:26439995 T/C cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs897080 0.515 rs1067345 chr2:44618897 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.0 0.37 5.46e-22 Height; BRCA cis rs832540 0.695 rs702686 chr5:56201350 A/G cg22800045 chr5:56110881 MAP3K1 0.42 8.58 0.32 6.92e-17 Coronary artery disease; BRCA cis rs4285028 0.948 rs6790281 chr3:121665543 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.6 -10.91 -0.4 1.59e-25 Multiple sclerosis; BRCA cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg25174290 chr11:3078921 CARS 0.43 12.86 0.45 7.94e-34 Longevity; BRCA cis rs9790314 1.000 rs460508 chr3:161091089 C/G cg04691961 chr3:161091175 C3orf57 0.6 14.78 0.5 9.57e-43 Morning vs. evening chronotype; BRCA cis rs35740288 0.539 rs4843100 chr15:86339210 G/C cg20737812 chr15:86336631 KLHL25 -0.39 -8.79 -0.33 1.36e-17 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA trans rs61931739 0.635 rs10772123 chr12:33975557 C/T cg26384229 chr12:38710491 ALG10B 0.4 9.03 0.34 2.08e-18 Morning vs. evening chronotype; BRCA cis rs6714710 0.603 rs11678591 chr2:98541001 T/C cg26665480 chr2:98280029 ACTR1B 0.57 13.39 0.47 3.18e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs6952808 0.531 rs4721441 chr7:2184060 A/G cg04267008 chr7:1944627 MAD1L1 -0.5 -10.61 -0.39 2.44e-24 Bipolar disorder and schizophrenia; BRCA cis rs6460942 1.000 rs111761262 chr7:12415916 T/C cg20607287 chr7:12443886 VWDE -0.57 -8.01 -0.3 5.27e-15 Coronary artery disease; BRCA cis rs4680 1.000 rs4633 chr22:19950235 C/T cg06346307 chr22:19949965 COMT 0.27 7.81 0.3 2.31e-14 Blood metabolite levels; BRCA cis rs2130392 0.926 rs1107907 chr4:185620108 G/T cg21366198 chr4:185655624 MLF1IP -0.43 -10.41 -0.38 1.51e-23 Kawasaki disease; BRCA cis rs12477438 0.520 rs34766932 chr2:99737273 G/A cg08885076 chr2:99613938 TSGA10 0.46 10.71 0.39 9.65e-25 Chronic sinus infection; BRCA cis rs7246657 0.943 rs10405407 chr19:37839164 C/T cg23950597 chr19:37808831 NA -0.62 -11.37 -0.41 2.02e-27 Coronary artery calcification; BRCA cis rs35146811 0.844 rs34031156 chr7:99677917 T/A cg13334819 chr7:99746414 C7orf59 -0.39 -9.56 -0.35 2.46e-20 Coronary artery disease; BRCA cis rs3733585 0.725 rs6449201 chr4:9973894 C/T cg11266682 chr4:10021025 SLC2A9 -0.38 -9.98 -0.37 6.78e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2014572 0.967 rs7259978 chr19:57756129 C/T cg24459738 chr19:57751996 ZNF805 -0.33 -7.98 -0.3 6.73e-15 Hyperactive-impulsive symptoms; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs2836974 0.897 rs6517513 chr21:40526878 A/G cg11890956 chr21:40555474 PSMG1 1.06 31.86 0.78 4.18e-134 Cognitive function; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 0.67 14.06 0.49 2.65e-39 Lymphocyte counts; BRCA cis rs1003719 0.591 rs1053984 chr21:38574018 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.59 -13.7 -0.48 1.2e-37 Eye color traits; BRCA cis rs6484504 0.553 rs413067 chr11:31223497 T/C cg26647111 chr11:31128758 NA -0.44 -9.63 -0.36 1.33e-20 Red blood cell count; BRCA cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg16325326 chr1:53192061 ZYG11B -0.56 -12.76 -0.45 2.14e-33 Monocyte count; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg27588902 chr6:42928151 GNMT -0.3 -10.11 -0.37 2.12e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs4819052 0.851 rs1006779 chr21:46670752 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.44 8.31 0.31 5.68e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs56235845 0.694 rs9313758 chr5:176773091 T/G cg06060754 chr5:176797920 RGS14 0.56 10.78 0.39 5.2e-25 Hemoglobin concentration;Hematocrit; BRCA cis rs4727027 0.933 rs6464940 chr7:148826309 G/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.39 9.02 0.34 2.2e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.15 -0.37 1.54e-22 Intelligence (multi-trait analysis); BRCA cis rs9457247 0.663 rs9459845 chr6:167440501 C/G cg07741184 chr6:167504864 NA 0.27 8.0 0.3 5.67e-15 Crohn's disease; BRCA cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.527 rs73212848 chr4:10093299 T/C cg02734326 chr4:10020555 SLC2A9 -0.37 -7.89 -0.3 1.31e-14 Bone mineral density; BRCA cis rs701145 0.585 rs357487 chr3:153885199 G/C cg17054900 chr3:154042577 DHX36 0.57 9.53 0.35 3.22e-20 Coronary artery disease; BRCA cis rs11190604 0.767 rs3829162 chr10:102172752 T/G cg07080220 chr10:102295463 HIF1AN 0.5 10.27 0.38 5.32e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs1008375 0.932 rs6845288 chr4:17665498 A/T cg16339924 chr4:17578868 LAP3 -0.58 -13.53 -0.47 7.28e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs79976124 0.837 rs12194087 chr6:66644399 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 11.2 0.41 1.01e-26 Type 2 diabetes; BRCA cis rs13217239 0.646 rs7747454 chr6:27034253 T/G cg12292205 chr6:26970375 C6orf41 -0.56 -12.34 -0.44 1.59e-31 Schizophrenia; BRCA cis rs6952808 0.692 rs11773316 chr7:2027354 C/T cg02951883 chr7:2050386 MAD1L1 -0.6 -15.06 -0.51 4.41e-44 Bipolar disorder and schizophrenia; BRCA cis rs4862307 0.762 rs28584149 chr4:184996482 C/T cg06737308 chr4:185021514 ENPP6 0.41 9.08 0.34 1.36e-18 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs2288073 0.965 rs10185445 chr2:24410976 A/C cg26838691 chr2:24397539 C2orf84 0.47 8.51 0.32 1.28e-16 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs2075371 0.796 rs35440439 chr7:134006094 C/T cg20476274 chr7:133979776 SLC35B4 0.6 14.82 0.51 6.17e-43 Mean platelet volume; BRCA cis rs6088580 0.634 rs6059850 chr20:33044784 C/G cg08999081 chr20:33150536 PIGU 0.47 12.93 0.46 3.78e-34 Glomerular filtration rate (creatinine); BRCA cis rs881375 0.967 rs2239658 chr9:123671837 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.52 10.93 0.4 1.26e-25 Rheumatoid arthritis; BRCA cis rs6121246 1.000 rs6121246 chr20:30433352 C/T cg13852791 chr20:30311386 BCL2L1 0.79 15.11 0.51 2.51e-44 Mean corpuscular hemoglobin; BRCA cis rs11711311 1.000 rs62268169 chr3:113493860 G/A cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.47 0.38 9.16e-24 IgG glycosylation; BRCA cis rs3106136 0.527 rs2865345 chr4:95156565 A/G cg11021082 chr4:95130006 SMARCAD1 -0.43 -9.92 -0.37 1.12e-21 Capecitabine sensitivity; BRCA trans rs61931739 0.500 rs3934517 chr12:34451396 T/C cg26384229 chr12:38710491 ALG10B 0.58 13.17 0.46 3.41e-35 Morning vs. evening chronotype; BRCA cis rs6951245 0.872 rs77434655 chr7:1098405 G/A cg18402987 chr7:1209562 NA 0.84 11.92 0.43 9.85e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7617773 0.817 rs4131362 chr3:48329036 A/C cg11946769 chr3:48343235 NME6 0.62 13.51 0.47 9.47e-37 Coronary artery disease; BRCA cis rs10256972 0.616 rs7806746 chr7:1075573 A/C cg04025307 chr7:1156635 C7orf50 0.46 11.24 0.41 6.84e-27 Longevity;Endometriosis; BRCA cis rs2836974 0.605 rs2836988 chr21:40707975 A/G cg11890956 chr21:40555474 PSMG1 -0.82 -19.27 -0.61 1.43e-65 Cognitive function; BRCA cis rs10504229 0.906 rs111838497 chr8:58185620 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs2304069 0.909 rs30831 chr5:149359053 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 -0.79 -15.76 -0.53 1.66e-47 HIV-1 control; BRCA trans rs1493916 0.601 rs7237379 chr18:31322540 C/T cg15819921 chr19:927150 ARID3A 0.47 9.08 0.34 1.39e-18 Life satisfaction; BRCA cis rs35110281 0.805 rs2838330 chr21:45023876 T/A cg04455712 chr21:45112962 RRP1B 0.38 10.09 0.37 2.53e-22 Mean corpuscular volume; BRCA cis rs7301826 0.651 rs10848206 chr12:131281471 G/C cg11011512 chr12:131303247 STX2 0.5 12.92 0.46 4.19e-34 Plasma plasminogen activator levels; BRCA cis rs9649213 0.593 rs62478200 chr7:97980045 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.6 -0.32 6.09e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs67311347 1.000 rs6762251 chr3:40531136 A/G cg09455208 chr3:40491958 NA -0.46 -11.2 -0.41 1.06e-26 Renal cell carcinoma; BRCA cis rs4812048 0.793 rs6070693 chr20:57589516 C/T cg14073986 chr20:57617431 SLMO2 0.62 8.71 0.33 2.54e-17 Mean platelet volume; BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.71 -13.35 -0.47 4.82e-36 Alzheimer's disease; BRCA trans rs208520 0.874 rs208517 chr6:66947040 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.45 -0.55 5.68e-51 Exhaled nitric oxide output; BRCA cis rs10870270 0.956 rs6557 chr10:133781449 C/T cg17892150 chr10:133769511 PPP2R2D -0.7 -14.84 -0.51 5.18e-43 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs7939886 0.688 rs11227290 chr11:55896577 A/G cg15704280 chr7:45808275 SEPT13 0.61 7.9 0.3 1.21e-14 Myopia (pathological); BRCA cis rs1801251 1.000 rs2675971 chr2:233726154 A/G cg25237894 chr2:233734115 C2orf82 -0.4 -11.7 -0.42 8.58e-29 Coronary artery disease; BRCA cis rs796364 0.806 rs203765 chr2:200903020 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -10.1 -0.37 2.41e-22 Schizophrenia; BRCA cis rs769267 0.930 rs6511038 chr19:19607564 A/C cg01262667 chr19:19385393 TM6SF2 0.41 10.64 0.39 1.95e-24 Tonsillectomy; BRCA cis rs61990749 0.597 rs7142390 chr14:78232880 T/C cg02301378 chr14:78227641 SNW1;C14orf178 0.64 9.47 0.35 5.52e-20 Fibroblast growth factor basic levels; BRCA cis rs9463078 0.774 rs4510673 chr6:45350107 A/G cg25276700 chr6:44698697 NA 0.35 8.08 0.3 3.28e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs72781680 0.898 rs12612492 chr2:24093756 C/T cg08917208 chr2:24149416 ATAD2B 0.98 14.9 0.51 2.63e-43 Lymphocyte counts; BRCA cis rs910316 0.967 rs4903292 chr14:75656245 A/G cg08847533 chr14:75593920 NEK9 0.8 19.8 0.62 2.21e-68 Height; BRCA cis rs3761847 0.508 rs4837813 chr9:123934463 C/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.4 0.32 2.9e-16 Rheumatoid arthritis; BRCA cis rs9612 0.950 rs346546 chr19:44256910 T/C cg08581076 chr19:44259116 C19orf61 0.52 9.64 0.36 1.31e-20 Exhaled nitric oxide output; BRCA cis rs2839627 0.561 rs2839601 chr21:44317381 A/G cg03543861 chr21:44258195 NA 0.39 7.95 0.3 8.74e-15 Information processing speed; BRCA cis rs752010 0.841 rs58737163 chr1:42079821 G/T cg06885757 chr1:42089581 HIVEP3 0.23 8.46 0.32 1.87e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs514406 0.679 rs11585495 chr1:53244331 T/C cg25767906 chr1:53392781 SCP2 0.52 11.04 0.4 4.71e-26 Monocyte count; BRCA cis rs4800452 0.956 rs4369779 chr18:20735408 T/C cg26136497 chr18:20735537 CABLES1 -0.44 -10.86 -0.39 2.41e-25 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs1865760 0.566 rs1800702 chr6:26086463 C/G cg16482183 chr6:26056742 HIST1H1C 0.53 11.49 0.41 6.29e-28 Height; BRCA cis rs2637030 0.559 rs256107 chr5:52873776 C/T cg06476337 chr5:52856530 NDUFS4 0.37 8.39 0.31 3.15e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA trans rs4698048 0.506 rs2080072 chr4:10235622 G/C cg26043149 chr18:55253948 FECH -0.54 -12.75 -0.45 2.59e-33 Skin aging (microtopography measurement); BRCA cis rs9400271 0.632 rs9398192 chr6:109587236 C/T cg21918786 chr6:109611834 NA -0.32 -8.02 -0.3 5.08e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs4727027 0.866 rs3927307 chr7:148774869 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.31 0.31 5.79e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs7824557 0.872 rs2572431 chr8:11105077 C/T cg06636001 chr8:8085503 FLJ10661 -0.46 -9.44 -0.35 6.8e-20 Retinal vascular caliber; BRCA cis rs3845702 0.736 rs12465592 chr2:180862654 C/G cg01881094 chr2:180872142 CWC22 1.01 17.22 0.56 6.97e-55 Schizophrenia; BRCA cis rs7811142 0.945 rs6955362 chr7:100056166 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.05 19.13 0.6 7.84e-65 Platelet count; BRCA cis rs4233366 0.585 rs3924264 chr1:161178684 C/T cg13853198 chr1:161185092 FCER1G -0.25 -8.78 -0.33 1.53e-17 Asthma; BRCA cis rs654950 0.934 rs654220 chr1:42002556 A/T cg06885757 chr1:42089581 HIVEP3 -0.28 -9.95 -0.37 8.87e-22 Airway imaging phenotypes; BRCA cis rs6582630 0.679 rs10785514 chr12:38573689 T/C cg26384229 chr12:38710491 ALG10B 0.43 10.43 0.38 1.27e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs9517313 0.770 rs9517301 chr13:99095088 A/G cg07423050 chr13:99094983 FARP1 -0.59 -16.02 -0.54 8.26e-49 Neuroticism; BRCA trans rs800082 0.501 rs9873732 chr3:144191665 C/T cg24215973 chr2:240111563 HDAC4 0.35 8.06 0.3 3.89e-15 Smoking behavior; BRCA cis rs2153535 0.580 rs1335637 chr6:8465101 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg12564285 chr5:131593104 PDLIM4 0.43 11.04 0.4 4.77e-26 Acylcarnitine levels; BRCA cis rs6088580 0.634 rs6088471 chr20:32932643 C/A cg08999081 chr20:33150536 PIGU -0.46 -12.55 -0.44 1.87e-32 Glomerular filtration rate (creatinine); BRCA cis rs7772486 0.727 rs10223508 chr6:146285205 C/T cg23711669 chr6:146136114 FBXO30 -0.68 -15.72 -0.53 2.47e-47 Lobe attachment (rater-scored or self-reported); BRCA cis rs12971120 0.891 rs12605820 chr18:72167802 G/A cg25817165 chr18:72167213 CNDP2 -0.74 -14.41 -0.5 6.03e-41 Refractive error; BRCA cis rs7586879 0.662 rs2384059 chr2:25100338 C/T cg04586622 chr2:25135609 ADCY3 0.44 11.13 0.4 2.05e-26 Body mass index; BRCA cis rs10461617 0.617 rs1423623 chr5:56065575 A/G cg24531977 chr5:56204891 C5orf35 0.61 12.54 0.44 2.04e-32 Type 2 diabetes; BRCA cis rs7666738 0.830 rs62318503 chr4:98935479 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7582180 0.663 rs2309794 chr2:100954270 G/A cg14675211 chr2:100938903 LONRF2 0.44 10.04 0.37 3.94e-22 Intelligence (multi-trait analysis); BRCA cis rs3806843 1.000 rs10477033 chr5:140169603 G/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.34 -0.35 1.6e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs7659604 0.560 rs769238 chr4:122744942 G/A cg06713675 chr4:122721982 EXOSC9 -0.53 -12.41 -0.44 7.92e-32 Type 2 diabetes; BRCA cis rs7178424 0.875 rs28513564 chr15:62232360 C/T cg00456672 chr15:62358751 C2CD4A -0.44 -9.73 -0.36 5.83e-21 Height; BRCA cis rs7264396 0.690 rs2425164 chr20:34434916 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.43 -0.52 7.17e-46 Total cholesterol levels; BRCA cis rs16854884 0.586 rs13081286 chr3:143723757 A/T cg06585982 chr3:143692056 C3orf58 0.47 10.09 0.37 2.62e-22 Economic and political preferences (feminism/equality); BRCA cis rs9467773 1.000 rs9467787 chr6:26556769 G/T cg11502198 chr6:26597334 ABT1 0.48 9.65 0.36 1.13e-20 Intelligence (multi-trait analysis); BRCA cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg27211696 chr2:191398769 TMEM194B 0.47 7.93 0.3 9.91e-15 Diastolic blood pressure; BRCA cis rs4363385 0.818 rs11205175 chr1:153001296 A/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.38 -0.31 3.47e-16 Inflammatory skin disease; BRCA cis rs826838 0.510 rs10876149 chr12:39228083 C/G cg13010199 chr12:38710504 ALG10B -0.44 -8.74 -0.33 1.98e-17 Heart rate; BRCA cis rs6088580 0.619 rs1205335 chr20:32927507 C/T cg06115741 chr20:33292138 TP53INP2 -0.39 -8.6 -0.32 6.16e-17 Glomerular filtration rate (creatinine); BRCA cis rs9503598 0.610 rs1328687 chr6:3468377 A/C cg00476032 chr6:3446245 SLC22A23 0.38 9.18 0.34 5.81e-19 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs10751667 0.961 rs6597971 chr11:928598 T/A cg10932868 chr11:921992 NA 0.4 9.74 0.36 5.43e-21 Alzheimer's disease (late onset); BRCA cis rs9393692 0.645 rs2179152 chr6:26325888 T/C cg13736514 chr6:26305472 NA -0.46 -14.8 -0.51 8.07e-43 Educational attainment; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg10729496 chr3:10149963 C3orf24 0.41 7.9 0.3 1.21e-14 Alzheimer's disease; BRCA cis rs13102973 1.000 rs4569802 chr4:135905371 A/C cg14419869 chr4:135874104 NA 0.47 9.71 0.36 6.77e-21 Subjective well-being; BRCA cis rs10256972 0.577 rs6962809 chr7:1208889 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 10.04 0.37 3.92e-22 Longevity;Endometriosis; BRCA cis rs757081 0.667 rs1987694 chr11:17107648 G/C cg15432903 chr11:17409602 KCNJ11 -0.46 -8.57 -0.32 7.52e-17 Systolic blood pressure; BRCA cis rs3857067 0.806 rs34396894 chr4:95097600 T/G cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.36 -0.35 1.32e-19 QT interval; BRCA cis rs9469890 0.604 rs11758426 chr6:34503338 A/G cg14254433 chr6:34482411 PACSIN1 -0.45 -9.47 -0.35 5.31e-20 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs10504229 0.683 rs7459958 chr8:58111905 G/T cg20607798 chr8:58055168 NA 0.47 8.09 0.3 3.07e-15 Developmental language disorder (linguistic errors); BRCA cis rs11718455 0.960 rs13060222 chr3:44005046 A/T cg08738300 chr3:44038990 NA 0.45 8.69 0.32 3.15e-17 Coronary artery disease; BRCA cis rs6570726 0.599 rs9403725 chr6:145897622 A/T cg05347473 chr6:146136440 FBXO30 -0.56 -10.25 -0.38 6.43e-23 Lobe attachment (rater-scored or self-reported); BRCA trans rs561341 1.000 rs550264 chr17:30317540 G/T cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.26e-27 Hip circumference adjusted for BMI; BRCA cis rs9393777 0.502 rs3823427 chr6:27256346 G/C cg12292205 chr6:26970375 C6orf41 -0.61 -10.1 -0.37 2.42e-22 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs3733523 chr4:120423719 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.06 0.3 3.79e-15 Corneal astigmatism; BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg00166722 chr3:10149974 C3orf24 0.56 10.94 0.4 1.22e-25 Alzheimer's disease; BRCA cis rs1215050 0.791 rs7434393 chr4:98768576 T/C cg05340658 chr4:99064831 C4orf37 0.45 10.36 0.38 2.44e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs6461049 0.734 rs1558465 chr7:2151398 G/C cg00106254 chr7:1943704 MAD1L1 -0.32 -8.12 -0.31 2.42e-15 Schizophrenia; BRCA cis rs490234 0.702 rs13284572 chr9:128258270 T/C cg14078157 chr9:128172775 NA -0.53 -11.75 -0.42 5.48e-29 Mean arterial pressure; BRCA cis rs1008375 0.966 rs4235392 chr4:17696422 A/G cg02297831 chr4:17616191 MED28 0.36 8.39 0.32 3.12e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2576037 0.544 rs629097 chr18:44378097 T/C cg19077165 chr18:44547161 KATNAL2 -0.58 -12.89 -0.45 5.75e-34 Personality dimensions; BRCA trans rs61931739 0.534 rs4931770 chr12:34044479 G/T cg26384229 chr12:38710491 ALG10B 0.68 14.28 0.49 2.34e-40 Morning vs. evening chronotype; BRCA cis rs36051895 0.659 rs61284219 chr9:5062816 C/A cg02405213 chr9:5042618 JAK2 -0.5 -9.67 -0.36 1.01e-20 Pediatric autoimmune diseases; BRCA cis rs425277 0.606 rs262653 chr1:2090095 T/G cg19257562 chr1:2043853 PRKCZ -0.35 -9.81 -0.36 2.95e-21 Height; BRCA cis rs11792861 0.781 rs28361152 chr9:111727529 T/C cg14432460 chr9:111696404 IKBKAP;C9orf6 0.46 8.19 0.31 1.41e-15 Menarche (age at onset); BRCA cis rs7618915 0.501 rs3852066 chr3:52621839 C/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.82 -0.42 2.58e-29 Bipolar disorder; BRCA cis rs10782582 0.593 rs11576534 chr1:76112751 C/T cg03433033 chr1:76189801 ACADM -0.48 -9.93 -0.37 1.02e-21 Daytime sleep phenotypes; BRCA cis rs9733 0.596 rs17658705 chr1:150678071 A/C cg04414720 chr1:150670196 GOLPH3L -0.35 -7.95 -0.3 8.2e-15 Tonsillectomy; BRCA cis rs2576037 0.558 rs7244778 chr18:44541915 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.99 0.43 5.35e-30 Personality dimensions; BRCA cis rs2180341 1.000 rs6569482 chr6:127631371 C/T cg27446573 chr6:127587934 RNF146 0.9 21.49 0.65 1.64e-77 Breast cancer; BRCA cis rs365132 0.902 rs353489 chr5:176461974 T/C cg16309518 chr5:176445507 NA -0.51 -12.95 -0.46 3.19e-34 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs74181299 0.684 rs12713532 chr2:65356552 G/C cg05010058 chr2:65284262 CEP68 -0.3 -8.19 -0.31 1.39e-15 Pulse pressure; BRCA cis rs67478160 0.619 rs28698555 chr14:104316486 C/A cg08213375 chr14:104286397 PPP1R13B -0.64 -17.82 -0.58 5.84e-58 Schizophrenia; BRCA cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06022373 chr22:39101656 GTPBP1 0.75 18.38 0.59 7.21e-61 Menopause (age at onset); BRCA cis rs2836950 0.585 rs1029004 chr21:40615343 A/G cg17971929 chr21:40555470 PSMG1 -0.49 -10.72 -0.39 9.04e-25 Menarche (age at onset); BRCA cis rs10876993 0.890 rs774888 chr12:58036506 A/G cg18357645 chr12:58087776 OS9 0.43 12.07 0.43 2.32e-30 Celiac disease or Rheumatoid arthritis; BRCA cis rs3008870 0.755 rs2815374 chr1:67507387 G/A cg08660285 chr1:67390436 MIER1;WDR78 0.63 13.68 0.48 1.46e-37 Lymphocyte percentage of white cells; BRCA cis rs8072100 0.701 rs10163469 chr17:45687767 G/A cg08085267 chr17:45401833 C17orf57 0.6 12.31 0.44 2.17e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6500602 0.727 rs1477123 chr16:4560627 T/A cg08645402 chr16:4508243 NA 0.41 9.67 0.36 1.01e-20 Schizophrenia; BRCA cis rs7552404 1.000 rs211718 chr1:76106675 C/T cg03433033 chr1:76189801 ACADM 0.7 16.08 0.54 3.97e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6598955 0.671 rs10493030 chr1:26561856 T/C cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs2777491 0.574 rs316611 chr15:41751678 A/G cg18705301 chr15:41695430 NDUFAF1 1.04 23.42 0.68 4.62e-88 Ulcerative colitis; BRCA cis rs10504229 0.906 rs6990615 chr8:58182956 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA trans rs6952808 0.595 rs3800916 chr7:2166072 C/T cg04565464 chr8:145669602 NFKBIL2 0.41 9.33 0.35 1.66e-19 Bipolar disorder and schizophrenia; BRCA cis rs600806 0.778 rs2043059 chr1:109991009 C/A cg20591472 chr1:110008990 SYPL2 0.32 8.07 0.3 3.58e-15 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.87 15.97 0.53 1.54e-48 Platelet count; BRCA cis rs1506636 0.854 rs6466879 chr7:123276197 G/A cg03229431 chr7:123269106 ASB15 -0.66 -15.3 -0.52 2.84e-45 Plateletcrit;Platelet count; BRCA cis rs7493 1.000 rs17876124 chr7:95045258 C/G cg01874867 chr7:94954059 PON1 -0.4 -8.13 -0.31 2.25e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg04267008 chr7:1944627 MAD1L1 0.49 10.99 0.4 7.37e-26 Bipolar disorder and schizophrenia; BRCA cis rs7607369 0.791 rs12468043 chr2:219354197 C/A cg10223061 chr2:219282414 VIL1 -0.27 -7.92 -0.3 1.04e-14 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs66887589 1.000 rs66887589 chr4:120509279 T/C cg25214090 chr10:38739885 LOC399744 -0.35 -7.89 -0.3 1.29e-14 Diastolic blood pressure; BRCA cis rs67478160 0.643 rs4900594 chr14:104251006 C/T cg26031613 chr14:104095156 KLC1 -0.45 -8.84 -0.33 9.49e-18 Schizophrenia; BRCA cis rs7772486 0.686 rs9497395 chr6:146013592 A/G cg23711669 chr6:146136114 FBXO30 -0.67 -15.46 -0.52 5.04e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 0.714 rs7250233 chr19:19630948 C/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA cis rs3806843 1.000 rs6898939 chr5:140169355 C/A cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.53 -0.35 3.1e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs12579753 0.912 rs4417392 chr12:82158722 C/A cg07988820 chr12:82153109 PPFIA2 -0.67 -11.22 -0.41 8.64e-27 Resting heart rate; BRCA cis rs11676348 0.818 rs4674256 chr2:218987893 A/T cg00012203 chr2:219082015 ARPC2 -0.4 -7.83 -0.3 2.1e-14 Ulcerative colitis; BRCA cis rs2880765 0.545 rs11631739 chr15:86012578 T/C cg10818794 chr15:86012489 AKAP13 -0.41 -11.07 -0.4 3.46e-26 Coronary artery disease; BRCA cis rs870825 0.616 rs4615214 chr4:185624129 G/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs2239547 0.618 rs3733047 chr3:52871929 A/G cg18404041 chr3:52824283 ITIH1 0.35 8.94 0.33 4.17e-18 Schizophrenia; BRCA cis rs919433 0.927 rs6759834 chr2:198204860 C/T cg00792783 chr2:198669748 PLCL1 -0.38 -8.04 -0.3 4.42e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA trans rs9858542 0.953 rs9841110 chr3:49492481 C/G cg21659725 chr3:3221576 CRBN -0.45 -9.61 -0.36 1.65e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs6461049 0.800 rs3800913 chr7:2163237 A/G cg04565464 chr8:145669602 NFKBIL2 0.44 10.59 0.39 3.02e-24 Schizophrenia; BRCA cis rs877282 0.583 rs11595057 chr10:819203 A/C cg15764593 chr10:829463 NA -0.5 -8.26 -0.31 8.13e-16 Uric acid levels; BRCA cis rs4665809 0.627 rs7562192 chr2:26469457 C/G cg08470875 chr2:26401718 FAM59B 0.72 11.85 0.42 2.09e-29 Gut microbiome composition (summer); BRCA cis rs6964587 0.692 rs2374550 chr7:91820987 A/G cg17063962 chr7:91808500 NA 0.57 12.96 0.46 2.76e-34 Breast cancer; BRCA cis rs7264396 0.563 rs2425109 chr20:34316218 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.18 -0.43 7.96e-31 Total cholesterol levels; BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg24549020 chr5:56110836 MAP3K1 0.59 12.05 0.43 2.86e-30 Initial pursuit acceleration; BRCA cis rs4948102 0.599 rs2230197 chr7:56126360 T/C cg09872392 chr7:56161020 PHKG1 -0.5 -12.51 -0.44 2.78e-32 Plasma homocysteine levels (post-methionine load test); BRCA cis rs2980439 0.846 rs2980437 chr8:8094763 C/T cg06636001 chr8:8085503 FLJ10661 -0.73 -16.34 -0.54 2.1e-50 Neuroticism; BRCA cis rs7312933 1.000 rs12372597 chr12:42412850 C/T cg17420585 chr12:42539391 GXYLT1 -0.49 -10.54 -0.38 4.52e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg11833968 chr6:79620685 NA -0.44 -9.91 -0.37 1.23e-21 Intelligence (multi-trait analysis); BRCA cis rs1997103 1.000 rs1997098 chr7:55405594 G/T cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4363385 0.693 rs821755 chr1:153036245 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.24 -0.31 9.7e-16 Inflammatory skin disease; BRCA cis rs3784262 1.000 rs4646638 chr15:58248783 C/T cg12031962 chr15:58353849 ALDH1A2 0.46 12.5 0.44 3.05e-32 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs1552244 1.000 rs6442150 chr3:10122575 T/C cg08888203 chr3:10149979 C3orf24 0.69 14.76 0.5 1.22e-42 Alzheimer's disease; BRCA cis rs2749592 1.000 rs2749592 chr10:38258842 A/C cg25427524 chr10:38739819 LOC399744 -0.59 -11.21 -0.41 9.06e-27 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3784262 0.679 rs11071365 chr15:58334126 G/A cg12031962 chr15:58353849 ALDH1A2 -0.55 -13.88 -0.48 1.72e-38 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs873946 0.586 rs12251911 chr10:134570595 A/G cg26818010 chr10:134567672 INPP5A -0.72 -15.21 -0.52 7.79e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs780096 0.506 rs1728922 chr2:27644464 A/C cg21248554 chr2:27665150 KRTCAP3 -0.35 -9.06 -0.34 1.62e-18 Total body bone mineral density; BRCA cis rs7833790 0.632 rs6415653 chr8:82702536 A/G cg17211192 chr8:82754475 SNX16 -0.54 -11.56 -0.42 3.52e-28 Diastolic blood pressure; BRCA cis rs6088590 1.000 rs6120747 chr20:33449769 T/C cg24642439 chr20:33292090 TP53INP2 0.7 15.9 0.53 3.15e-48 Coronary artery disease; BRCA cis rs10193935 0.901 rs222463 chr2:42644080 A/G cg27598129 chr2:42591480 NA -0.81 -13.38 -0.47 3.6e-36 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.534 rs11053075 chr12:34207009 A/G cg13010199 chr12:38710504 ALG10B -0.48 -9.38 -0.35 1.16e-19 Morning vs. evening chronotype; BRCA cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg13271783 chr10:134563150 INPP5A -0.48 -9.58 -0.35 2.06e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.37 0.38 2.23e-23 Motion sickness; BRCA cis rs7552404 1.000 rs12127402 chr1:76205643 C/A cg22875332 chr1:76189707 ACADM 0.69 14.77 0.5 1.08e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4853036 1.000 rs62134006 chr2:70050641 T/C cg02498382 chr2:70120550 SNRNP27 -0.49 -8.97 -0.33 3.22e-18 Colorectal or endometrial cancer; BRCA cis rs2112347 0.502 rs34339 chr5:74931333 G/T cg19683494 chr5:74908142 NA -0.62 -9.7 -0.36 7.66e-21 Body mass index (joint analysis main effects and smoking interaction);Waist circumference;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Hip circumference;Body mass index;Body mass index in physically active individuals;Obesity; BRCA cis rs2282802 0.660 rs4463213 chr5:139545748 G/A cg26211634 chr5:139558579 C5orf32 -0.34 -8.05 -0.3 3.94e-15 Intelligence (multi-trait analysis); BRCA cis rs2762353 0.574 rs9461204 chr6:25718466 A/G cg03517284 chr6:25882590 NA 0.67 15.2 0.52 9.32e-45 Blood metabolite levels; BRCA cis rs495337 0.760 rs471054 chr20:48513236 C/T cg17835207 chr20:48524531 SPATA2 -0.67 -15.82 -0.53 7.95e-48 Psoriasis; BRCA trans rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05039488 chr6:79577232 IRAK1BP1 0.53 12.77 0.45 2.1e-33 Brugada syndrome; BRCA cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.63 0.32 4.93e-17 Mean platelet volume; BRCA cis rs6815814 0.950 rs11722889 chr4:38810975 C/T cg06935464 chr4:38784597 TLR10 0.51 8.25 0.31 9.26e-16 Breast cancer; BRCA cis rs17253792 0.915 rs17832389 chr14:56185836 A/G cg01858014 chr14:56050164 KTN1 -0.66 -8.26 -0.31 8.58e-16 Putamen volume; BRCA cis rs8062405 0.755 rs4788080 chr16:28558081 C/T cg16576597 chr16:28551801 NUPR1 0.36 9.68 0.36 8.82e-21 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9649213 0.555 rs6956686 chr7:97997945 T/C cg21770322 chr7:97807741 LMTK2 0.45 11.72 0.42 7.35e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.69 0.39 1.15e-24 Tonsillectomy; BRCA cis rs9287719 0.967 rs4555318 chr2:10744295 C/G cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.72e-15 Prostate cancer; BRCA cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg18016565 chr1:150552671 MCL1 -0.37 -8.56 -0.32 8.12e-17 Tonsillectomy; BRCA cis rs17685 0.736 rs4732594 chr7:75753273 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.69 -0.33 3.09e-17 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4308124 0.708 rs2137168 chr2:111986509 C/T cg04571233 chr2:111982156 NA -0.46 -9.25 -0.34 3.21e-19 Vitiligo; BRCA cis rs727479 0.502 rs10046 chr15:51502986 G/A cg19946085 chr15:51559439 CYP19A1 -0.3 -8.32 -0.31 5.5e-16 Estradiol levels; BRCA cis rs9487051 1.000 rs9374080 chr6:109616420 C/T cg01475377 chr6:109611718 NA 0.53 13.49 0.47 1.16e-36 Reticulocyte fraction of red cells; BRCA cis rs933688 0.938 rs6866923 chr5:90669352 A/C cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.93 21.05 0.64 3.91e-75 Smoking behavior; BRCA cis rs2842992 0.830 rs2025189 chr6:160137518 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.74 0.55 2.09e-52 Age-related macular degeneration (geographic atrophy); BRCA cis rs11229555 0.834 rs7925560 chr11:58263036 G/A cg15696309 chr11:58395628 NA -0.54 -11.65 -0.42 1.45e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs7618915 0.501 rs11130308 chr3:52639257 G/C cg18404041 chr3:52824283 ITIH1 -0.38 -11.76 -0.42 5.03e-29 Bipolar disorder; BRCA cis rs10782582 0.593 rs12126155 chr1:76131555 C/G cg03433033 chr1:76189801 ACADM -0.47 -8.98 -0.33 3.1e-18 Daytime sleep phenotypes; BRCA cis rs13118159 0.550 rs1137789 chr4:1381798 A/G cg19318889 chr4:1322082 MAEA 0.49 10.54 0.38 4.74e-24 Longevity; BRCA cis rs4819052 0.684 rs914216 chr21:46698298 T/G cg11663144 chr21:46675770 NA -0.62 -14.33 -0.49 1.41e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9611519 0.780 rs2235852 chr22:41661154 G/T cg03806693 chr22:41940476 POLR3H -0.55 -10.39 -0.38 1.84e-23 Neuroticism; BRCA cis rs7777754 0.512 rs4470989 chr7:50562698 T/A cg18232548 chr7:50535776 DDC -0.5 -12.42 -0.44 6.83e-32 Response to zileuton treatment in asthma (FEV1 change interaction); BRCA cis rs4481887 0.893 rs10736379 chr1:248455876 A/T cg00666640 chr1:248458726 OR2T12 0.31 8.27 0.31 7.63e-16 Common traits (Other); BRCA cis rs1614887 1 rs1614887 chr6:26393021 A/G cg09904177 chr6:26538194 HMGN4 0.41 11.23 0.41 8.14e-27 Intelligence (multi-trait analysis);Lobe attachment (rater-scored or self-reported); BRCA cis rs6142102 0.649 rs4911382 chr20:32553095 C/T cg24642439 chr20:33292090 TP53INP2 0.39 7.82 0.3 2.17e-14 Skin pigmentation; BRCA cis rs13191362 1.000 rs13200329 chr6:163004418 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.02 0.3 5.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6963495 0.649 rs1706888 chr7:105149176 A/G cg19920283 chr7:105172520 RINT1 0.43 8.93 0.33 4.67e-18 Bipolar disorder (body mass index interaction); BRCA cis rs7552404 1.000 rs4949879 chr1:76237143 G/A cg10523679 chr1:76189770 ACADM 0.67 13.31 0.47 7.77e-36 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11608355 0.515 rs1045582 chr12:109915727 G/T cg05360138 chr12:110035743 NA 0.72 13.15 0.46 4.04e-35 Neuroticism; BRCA cis rs7666738 0.830 rs35433756 chr4:99070555 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.23e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.862 rs6978028 chr7:65886300 G/C cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs7727544 0.901 rs55633655 chr5:131598756 T/G cg14196790 chr5:131705035 SLC22A5 0.3 7.85 0.3 1.73e-14 Blood metabolite levels; BRCA cis rs6424115 0.708 rs11803575 chr1:24182348 A/T cg10978503 chr1:24200527 CNR2 -0.44 -10.12 -0.37 2.07e-22 Immature fraction of reticulocytes; BRCA cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs9467711 0.591 rs13196552 chr6:25974204 A/G cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.58 9.13 0.34 9e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs60871478 0.679 rs6962050 chr7:817201 A/G cg06242242 chr7:766104 PRKAR1B;HEATR2 0.56 8.12 0.31 2.43e-15 Cerebrospinal P-tau181p levels; BRCA cis rs6835098 1.000 rs6835098 chr4:174089238 T/C cg08422745 chr4:174089978 GALNT7 -0.82 -18.11 -0.58 1.87e-59 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs1011018 0.628 rs56079671 chr7:139466379 G/A cg03224163 chr7:139420300 HIPK2 -0.58 -8.68 -0.32 3.41e-17 Systolic blood pressure; BRCA cis rs769267 0.965 rs8101938 chr19:19390497 G/A cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.71e-14 Tonsillectomy; BRCA cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.43 -9.15 -0.34 7.87e-19 IgG glycosylation; BRCA trans rs61931739 0.500 rs11053213 chr12:34466395 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.68 0.36 9.21e-21 Morning vs. evening chronotype; BRCA trans rs12517041 1.000 rs10520888 chr5:23280539 A/G ch.8.1293020R chr8:59333349 UBXN2B -0.44 -8.06 -0.3 3.89e-15 Calcium levels; BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg00802000 chr16:706648 WDR90 -0.41 -9.6 -0.36 1.73e-20 Height; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg12016809 chr21:47604291 C21orf56 -0.39 -8.12 -0.31 2.37e-15 Testicular germ cell tumor; BRCA cis rs7666738 0.678 rs7670805 chr4:99008763 A/G cg03676636 chr4:99064102 C4orf37 0.21 7.98 0.3 6.8e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2404618 0.593 rs7815979 chr8:1484887 A/G cg13402656 chr8:1511478 DLGAP2 -0.49 -11.94 -0.43 8.26e-30 Lung cancer; BRCA cis rs7520050 0.931 rs11211224 chr1:46384388 G/A cg24296786 chr1:45957014 TESK2 0.44 9.76 0.36 4.46e-21 Red blood cell count;Reticulocyte count; BRCA cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg11663144 chr21:46675770 NA -0.61 -13.91 -0.48 1.22e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs875971 0.862 rs6964437 chr7:65686444 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.97 -0.3 7.43e-15 Aortic root size; BRCA cis rs1865760 0.566 rs2032445 chr6:26044812 T/A cg17691542 chr6:26056736 HIST1H1C 0.54 11.35 0.41 2.55e-27 Height; BRCA cis rs2625529 0.652 rs8028115 chr15:72339503 C/T cg16672083 chr15:72433130 SENP8 0.65 15.47 0.52 4.46e-46 Red blood cell count; BRCA cis rs9467773 1.000 rs9393728 chr6:26509330 C/G cg09904177 chr6:26538194 HMGN4 0.56 18.26 0.59 3.11e-60 Intelligence (multi-trait analysis); BRCA cis rs7264396 0.635 rs6060656 chr20:34466382 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.72 -14.97 -0.51 1.13e-43 Total cholesterol levels; BRCA trans rs11039798 0.588 rs589834 chr11:48419382 C/G cg15704280 chr7:45808275 SEPT13 -0.49 -8.2 -0.31 1.36e-15 Axial length; BRCA cis rs672059 1.000 rs546183 chr1:183157753 A/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.08e-17 Hypertriglyceridemia; BRCA cis rs7267979 0.966 rs6083855 chr20:25405118 A/G cg08601574 chr20:25228251 PYGB -0.33 -7.97 -0.3 7.24e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17783634 0.509 rs11775489 chr8:11036843 T/C cg21775007 chr8:11205619 TDH -0.48 -9.68 -0.36 8.68e-21 Subjective well-being; BRCA cis rs2070488 0.775 rs2051214 chr3:38560303 C/A cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.56 -14.12 -0.49 1.41e-39 Electrocardiographic conduction measures; BRCA cis rs10504229 0.724 rs73603871 chr8:58107612 A/G cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA cis rs7618501 0.633 rs4688755 chr3:50064424 G/A cg05623727 chr3:50126028 RBM5 -0.41 -9.6 -0.35 1.8e-20 Intelligence (multi-trait analysis); BRCA cis rs2032447 0.670 rs198820 chr6:26124243 G/A cg03264133 chr6:25882463 NA 0.42 8.84 0.33 9.1e-18 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.647 rs6060268 chr20:33734293 T/C cg24642439 chr20:33292090 TP53INP2 0.4 8.6 0.32 5.93e-17 Height; BRCA cis rs7666738 0.830 rs7657497 chr4:99044028 A/G cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs13136331 0.840 rs13113106 chr4:88704009 T/G cg22416721 chr4:88570574 DMP1 0.46 10.2 0.37 9.71e-23 Sitting height ratio; BRCA cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.68e-16 Putamen volume; BRCA cis rs9291683 0.588 rs3796842 chr4:9995851 A/T cg00071950 chr4:10020882 SLC2A9 0.55 13.8 0.48 4.22e-38 Bone mineral density; BRCA cis rs6450176 0.625 rs56193151 chr5:53287790 C/T ch.5.1024479R chr5:53302184 ARL15 -0.7 -15.64 -0.53 6.06e-47 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.94 0.51 1.75e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs12310956 0.527 rs10772117 chr12:33900096 C/T cg26384229 chr12:38710491 ALG10B 0.45 10.5 0.38 6.5e-24 Morning vs. evening chronotype; BRCA cis rs2294693 0.945 rs9369255 chr6:40989503 T/C cg14418226 chr6:40996092 UNC5CL 0.45 8.03 0.3 4.75e-15 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs586533 0.758 rs1690819 chr11:99496535 A/G cg22878054 chr11:99397252 CNTN5 0.32 7.85 0.3 1.8e-14 Depressive symptoms (multi-trait analysis); BRCA trans rs10506458 1.000 rs10506458 chr12:63445092 G/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.18 -17.87 -0.58 3.08e-58 Hemostatic factors and hematological phenotypes; BRCA cis rs1003719 0.614 rs1053808 chr21:38525356 T/C cg10648535 chr21:38446584 PIGP;TTC3 -0.58 -13.42 -0.47 2.43e-36 Eye color traits; BRCA cis rs2404602 0.672 rs35374222 chr15:77071394 G/T cg23625390 chr15:77176239 SCAPER -0.55 -12.86 -0.45 8.09e-34 Blood metabolite levels; BRCA cis rs8031584 0.541 rs1983459 chr15:31208749 C/T cg08704250 chr15:31115839 NA -0.35 -9.04 -0.34 1.78e-18 Huntington's disease progression; BRCA cis rs7267979 1.000 rs11100 chr20:25281184 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.1e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs372883 0.613 rs1153289 chr21:30686212 G/T cg24692254 chr21:30365293 RNF160 -0.46 -10.34 -0.38 2.86e-23 Pancreatic cancer; BRCA cis rs2625529 0.878 rs4777478 chr15:72279085 T/C cg16672083 chr15:72433130 SENP8 -0.86 -17.75 -0.57 1.34e-57 Red blood cell count; BRCA cis rs4237845 0.742 rs6650219 chr12:58289100 T/C cg02175503 chr12:58329896 NA 0.56 13.08 0.46 8.38e-35 Intelligence (multi-trait analysis); BRCA cis rs67478160 0.704 rs12894254 chr14:104290949 G/C cg08213375 chr14:104286397 PPP1R13B 0.66 18.72 0.6 1.09e-62 Schizophrenia; BRCA cis rs6879260 1.000 rs7725605 chr5:179732678 T/G cg02891314 chr5:179741120 GFPT2 -0.7 -14.41 -0.5 5.5e-41 Height; BRCA cis rs6424115 1.000 rs7514394 chr1:24100223 A/G cg15997130 chr1:24165203 NA -0.47 -12.59 -0.45 1.29e-32 Immature fraction of reticulocytes; BRCA cis rs9443645 0.869 rs9448591 chr6:79606490 C/T cg09184832 chr6:79620586 NA -0.51 -11.3 -0.41 3.9e-27 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg05340658 chr4:99064831 C4orf37 0.68 16.88 0.56 3.89e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs977987 0.806 rs4146809 chr16:75415775 A/G cg03315344 chr16:75512273 CHST6 -0.54 -13.0 -0.46 1.81e-34 Dupuytren's disease; BRCA cis rs2070488 1.000 rs1841777 chr3:38484819 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.72 20.19 0.62 1.8e-70 Electrocardiographic conduction measures; BRCA cis rs12477438 0.765 rs62154638 chr2:99639584 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.75 -0.53 1.79e-47 Chronic sinus infection; BRCA trans rs7746199 0.736 rs13192965 chr6:27671825 G/A cg01620082 chr3:125678407 NA -0.92 -10.33 -0.38 2.97e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs11997175 0.766 rs7387133 chr8:33727045 C/G ch.8.33884649F chr8:33765107 NA -0.37 -8.92 -0.33 4.76e-18 Body mass index; BRCA cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg05623727 chr3:50126028 RBM5 -0.43 -10.51 -0.38 6.07e-24 Intelligence (multi-trait analysis); BRCA cis rs10504229 1.000 rs1390411 chr8:58194146 C/A cg14926445 chr8:58193284 C8orf71 -0.44 -8.43 -0.32 2.32e-16 Developmental language disorder (linguistic errors); BRCA cis rs2629540 0.580 rs2930796 chr10:126485684 A/G cg08799069 chr10:126477246 METTL10 0.46 8.31 0.31 5.95e-16 Cocaine dependence; BRCA cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.35 10.96 0.4 9.76e-26 Bipolar disorder; BRCA trans rs7746199 0.736 rs34965299 chr6:27521856 A/G cg01620082 chr3:125678407 NA -0.85 -9.88 -0.36 1.6e-21 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs72781680 0.716 rs2551326 chr2:23982378 T/C cg08917208 chr2:24149416 ATAD2B 0.63 9.98 0.37 6.5600000000000005e-22 Lymphocyte counts; BRCA cis rs10782582 0.593 rs12131493 chr1:76139172 G/A cg10523679 chr1:76189770 ACADM -0.45 -8.59 -0.32 6.59e-17 Daytime sleep phenotypes; BRCA cis rs858239 0.932 rs1637190 chr7:23269065 A/G cg23682824 chr7:23144976 KLHL7 0.35 8.96 0.33 3.44e-18 Cerebrospinal fluid biomarker levels; BRCA cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg07828340 chr4:882639 GAK 1.07 14.36 0.49 9.99e-41 Intelligence (multi-trait analysis); BRCA cis rs7827545 1.000 rs4909909 chr8:135564627 T/C cg17885191 chr8:135476712 NA 0.47 9.19 0.34 5.3e-19 Hypertension (SNP x SNP interaction); BRCA cis rs9291683 0.609 rs3796836 chr4:10011345 A/G cg00071950 chr4:10020882 SLC2A9 0.65 16.08 0.54 4.3e-49 Bone mineral density; BRCA cis rs4242434 0.927 rs10099846 chr8:22534178 C/T cg03733263 chr8:22462867 KIAA1967 -0.85 -17.5 -0.57 2.54e-56 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs13064411 0.735 rs6438157 chr3:113207316 G/T cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs4321325 0.536 rs10198483 chr2:127934102 G/A cg11380483 chr2:127933992 NA 0.53 12.45 0.44 5.03e-32 Protein C levels; BRCA cis rs798554 0.679 rs2644281 chr7:2886748 A/G cg19346786 chr7:2764209 NA -0.3 -9.4 -0.35 9.79e-20 Height; BRCA cis rs2439831 0.850 rs28524541 chr15:44124831 A/G cg27015174 chr15:43622946 ADAL;LCMT2 0.49 9.51 0.35 3.8e-20 Lung cancer in ever smokers; BRCA cis rs6582630 0.533 rs2120464 chr12:38280289 A/C cg26384229 chr12:38710491 ALG10B 0.43 9.86 0.36 1.99e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg22920501 chr2:26401640 FAM59B 0.94 16.57 0.55 1.46e-51 Gut microbiome composition (summer); BRCA cis rs6750047 1.000 rs6750047 chr2:38276549 A/G cg07380506 chr2:38303506 CYP1B1 0.42 9.62 0.36 1.5e-20 Cutaneous malignant melanoma;Melanoma; BRCA cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg26913058 chr16:419975 MRPL28 -0.32 -7.87 -0.3 1.51e-14 Bone mineral density (spine);Bone mineral density; BRCA cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.54 -10.56 -0.39 4.01e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7615952 0.641 rs4422257 chr3:125774363 A/G cg15145296 chr3:125709740 NA -0.54 -8.57 -0.32 7.5e-17 Blood pressure (smoking interaction); BRCA cis rs7394190 0.748 rs4114992 chr10:75566829 A/G cg07699608 chr10:75541558 CHCHD1 0.62 9.44 0.35 6.91e-20 Incident atrial fibrillation; BRCA cis rs4853012 0.838 rs72915068 chr2:74356185 G/A cg19729930 chr2:74357872 NA 0.6 14.49 0.5 2.49e-41 Gestational age at birth (maternal effect); BRCA trans rs9325144 0.560 rs10785562 chr12:38637419 A/C cg23762105 chr12:34175262 ALG10 0.34 7.9 0.3 1.25e-14 Morning vs. evening chronotype; BRCA cis rs9811920 0.609 rs6765027 chr3:99687730 A/G cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.18 0.31 1.49e-15 Axial length; BRCA cis rs8044868 0.530 rs12918956 chr16:72224335 A/G cg23815491 chr16:72088622 HP -0.32 -8.27 -0.31 7.65e-16 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA trans rs561341 0.882 rs2521594 chr17:30302087 C/T cg20587970 chr11:113659929 NA -1.2 -22.12 -0.66 5.89e-81 Hip circumference adjusted for BMI; BRCA cis rs911119 0.913 rs6048928 chr20:23585988 A/G cg16589663 chr20:23618590 CST3 0.45 8.28 0.31 7.17e-16 Chronic kidney disease; BRCA cis rs2836974 0.644 rs2836982 chr21:40689171 C/A cg06238570 chr21:40685208 BRWD1 -0.46 -9.16 -0.34 6.94e-19 Cognitive function; BRCA cis rs6570726 0.846 rs371186 chr6:145886971 T/C cg23711669 chr6:146136114 FBXO30 0.72 17.35 0.57 1.59e-55 Lobe attachment (rater-scored or self-reported); BRCA trans rs12458462 0.892 rs2007483 chr18:77476131 A/T cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.46 -8.83 -0.33 1e-17 Monocyte count; BRCA cis rs72781680 0.784 rs72798406 chr2:24180144 T/C cg08917208 chr2:24149416 ATAD2B 0.62 10.37 0.38 2.18e-23 Lymphocyte counts; BRCA cis rs2204008 0.571 rs8175738 chr12:38311234 C/T cg26384229 chr12:38710491 ALG10B -0.43 -9.75 -0.36 4.79e-21 Bladder cancer; BRCA cis rs9549328 0.800 rs9549326 chr13:113630453 C/T cg22951483 chr13:113628068 MCF2L -0.37 -8.24 -0.31 9.61e-16 Systolic blood pressure; BRCA cis rs2153535 0.580 rs9328488 chr6:8529411 G/C cg07606381 chr6:8435919 SLC35B3 0.64 14.2 0.49 5.86e-40 Motion sickness; BRCA cis rs724568 0.546 rs10191089 chr2:67941210 C/T cg14046302 chr2:67939758 NA -0.4 -10.95 -0.4 1.08e-25 Major depressive disorder (broad); BRCA cis rs5167 0.504 rs7246900 chr19:45454236 G/A cg10169327 chr19:45448959 APOC2 0.31 7.84 0.3 1.85e-14 Blood protein levels; BRCA cis rs8032158 0.927 rs7179116 chr15:56174827 A/G cg02198044 chr15:56286336 NEDD4 -0.38 -9.14 -0.34 8.39e-19 Keloid; BRCA cis rs68170813 0.559 rs77727587 chr7:106815754 C/G cg02696742 chr7:106810147 HBP1 -0.54 -8.8 -0.33 1.3e-17 Coronary artery disease; BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg17372223 chr3:52568218 NT5DC2 0.34 7.97 0.3 7.48e-15 Electroencephalogram traits; BRCA cis rs7613875 0.600 rs2856238 chr3:50158191 C/T cg14019146 chr3:50243930 SLC38A3 -0.39 -9.56 -0.35 2.53e-20 Body mass index; BRCA cis rs3749237 0.964 rs2234385 chr3:49846041 G/A cg03060546 chr3:49711283 APEH 0.47 10.13 0.37 1.84e-22 Resting heart rate; BRCA cis rs6701037 0.555 rs10912899 chr1:175120715 C/T cg17845761 chr1:175162550 KIAA0040 0.28 10.56 0.39 3.89e-24 Alcohol dependence; BRCA cis rs12950390 0.853 rs8078052 chr17:45859434 A/G cg24803719 chr17:45855879 NA -0.31 -8.06 -0.3 3.76e-15 IgG glycosylation; BRCA cis rs6089829 0.890 rs6062775 chr20:61663650 T/C cg02544614 chr20:61657117 NA 0.29 8.14 0.31 2.09e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11890956 chr21:40555474 PSMG1 0.66 14.4 0.5 6.08e-41 Cognitive function; BRCA cis rs6484504 0.652 rs485265 chr11:31407788 G/A cg06552810 chr11:31128660 NA 0.39 8.42 0.32 2.4e-16 Red blood cell count; BRCA cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg20908204 chr19:46285434 DMPK 0.29 8.99 0.34 2.68e-18 Coronary artery disease; BRCA cis rs875971 0.895 rs3857684 chr7:65938158 G/C cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.76e-35 Aortic root size; BRCA cis rs1568889 1.000 rs12800354 chr11:28047723 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.68 13.41 0.47 2.64e-36 Bipolar disorder; BRCA cis rs7617773 0.747 rs34076262 chr3:48370416 C/T cg11946769 chr3:48343235 NME6 0.67 13.66 0.48 1.88e-37 Coronary artery disease; BRCA cis rs965469 1.000 rs6037560 chr20:3323055 T/C cg25506879 chr20:3388711 C20orf194 -0.55 -10.72 -0.39 8.86e-25 IFN-related cytopenia; BRCA cis rs2204008 0.715 rs11495369 chr12:38238673 T/C cg26384229 chr12:38710491 ALG10B 0.69 15.69 0.53 3.64e-47 Bladder cancer; BRCA cis rs477895 0.713 rs12787852 chr11:63954648 G/A cg23719950 chr11:63933701 MACROD1 -0.58 -9.47 -0.35 5.18e-20 Mean platelet volume; BRCA cis rs2204008 0.548 rs2320740 chr12:38166421 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.93 0.33 4.46e-18 Bladder cancer; BRCA cis rs7666738 0.830 rs34671152 chr4:98978177 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs919433 0.713 rs55642934 chr2:198491110 C/T cg00792783 chr2:198669748 PLCL1 0.36 8.08 0.3 3.27e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4862750 0.957 rs6858853 chr4:187903412 A/C cg22105103 chr4:187893119 NA -0.36 -11.7 -0.42 8.31e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs1865760 0.519 rs4360119 chr6:25815074 C/G cg17691542 chr6:26056736 HIST1H1C 0.53 10.32 0.38 3.45e-23 Height; BRCA cis rs12364620 1 rs12364620 chr11:68252123 T/G cg20283391 chr11:68216788 NA -0.49 -9.52 -0.35 3.55e-20 Total body bone mineral density (age 0-15); BRCA cis rs4819052 0.851 rs28622522 chr21:46676599 G/T cg11663144 chr21:46675770 NA -0.61 -14.21 -0.49 5.05e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17685 0.712 rs10271413 chr7:75754858 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -9.14 -0.34 8.23e-19 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4332037 0.624 rs11766944 chr7:1888051 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -10.64 -0.39 1.82e-24 Bipolar disorder; BRCA cis rs6580649 0.943 rs3803183 chr12:48398080 T/A cg24011408 chr12:48396354 COL2A1 0.52 8.85 0.33 8.55e-18 Lung cancer; BRCA cis rs3750965 0.575 rs3892895 chr11:68884755 A/G cg06818126 chr11:68850279 TPCN2 0.35 8.93 0.33 4.58e-18 Hair color; BRCA cis rs6062302 0.522 rs3810492 chr20:62219740 G/A cg03425785 chr20:62221387 GMEB2 0.51 8.29 0.31 6.8e-16 Glioblastoma; BRCA trans rs2727020 0.688 rs2734002 chr11:49234162 A/G cg15704280 chr7:45808275 SEPT13 0.8 19.2 0.6 3.31e-65 Coronary artery disease; BRCA cis rs9640161 0.830 rs76741564 chr7:150059529 A/T cg12556325 chr7:150026731 C7orf29;LRRC61 -0.55 -12.7 -0.45 4.24e-33 Blood protein levels;Circulating chemerin levels; BRCA cis rs4665809 1.000 rs6546727 chr2:26275282 C/T cg22920501 chr2:26401640 FAM59B -0.65 -11.41 -0.41 1.45e-27 Gut microbiome composition (summer); BRCA trans rs2204008 0.583 rs12820907 chr12:37990931 T/C cg06521331 chr12:34319734 NA -0.54 -10.34 -0.38 2.7e-23 Bladder cancer; BRCA cis rs10504229 1.000 rs67546820 chr8:58168567 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.41 -0.47 2.55e-36 Developmental language disorder (linguistic errors); BRCA cis rs7677751 0.806 rs17084051 chr4:55087581 C/A cg17187183 chr4:55093834 PDGFRA 0.44 9.21 0.34 4.62e-19 Corneal astigmatism; BRCA cis rs8114671 0.562 rs4911450 chr20:33512406 C/T cg07148914 chr20:33460835 GGT7 0.47 9.97 0.37 7.37e-22 Height; BRCA cis rs7666738 0.830 rs1869897 chr4:98730997 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.69 0.36 8.26e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs7552404 0.924 rs7544117 chr1:76158246 A/G cg03433033 chr1:76189801 ACADM 0.86 22.18 0.66 2.75e-81 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2404602 0.716 rs56351018 chr15:76824591 T/C cg22467129 chr15:76604101 ETFA -0.48 -10.47 -0.38 8.45e-24 Blood metabolite levels; BRCA cis rs1577917 0.518 rs2475787 chr6:86415236 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.43 12.7 0.45 4.07e-33 Response to antipsychotic treatment; BRCA cis rs2795502 0.630 rs4948698 chr10:43539459 A/G cg08461752 chr10:43522343 NA 0.5 9.57 0.35 2.3e-20 Blood protein levels; BRCA cis rs514406 0.505 rs447581 chr1:53177098 T/C cg16325326 chr1:53192061 ZYG11B 0.8 22.04 0.66 1.62e-80 Monocyte count; BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.61 -12.75 -0.45 2.45e-33 Lymphocyte counts; BRCA cis rs4680 1.000 rs4633 chr22:19950235 C/T cg23601416 chr22:19950040 COMT 0.34 11.08 0.4 3.14e-26 Blood metabolite levels; BRCA cis rs708547 0.647 rs4864609 chr4:57878141 T/A cg16868167 chr4:57843880 C4orf14;POLR2B 0.38 9.82 0.36 2.67e-21 Response to bleomycin (chromatid breaks); BRCA cis rs3125734 0.572 rs3864794 chr10:64041956 A/C cg09941381 chr10:64027924 RTKN2 -0.28 -7.94 -0.3 8.89e-15 Rheumatoid arthritis; BRCA cis rs13191362 1.000 rs68144677 chr6:163149024 T/C cg21926612 chr6:163149169 PACRG;PARK2 1.06 15.87 0.53 4.42e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg26119090 chr2:26468346 HADHA;HADHB 1.02 18.08 0.58 2.69e-59 Gut microbiome composition (summer); BRCA cis rs2204008 0.837 rs11181857 chr12:38413255 C/G cg26384229 chr12:38710491 ALG10B 0.66 15.45 0.52 5.71e-46 Bladder cancer; BRCA cis rs9790314 0.812 rs2004862 chr3:161135638 C/T cg03342759 chr3:160939853 NMD3 -0.52 -11.14 -0.4 1.8e-26 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs2873638 chr8:58114593 G/A cg24829409 chr8:58192753 C8orf71 -0.47 -9.11 -0.34 1.01e-18 Developmental language disorder (linguistic errors); BRCA trans rs9329221 0.662 rs35472251 chr8:10246669 A/G cg06636001 chr8:8085503 FLJ10661 0.56 11.07 0.4 3.47e-26 Neuroticism; BRCA cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg26384229 chr12:38710491 ALG10B 0.7 15.94 0.53 1.97e-48 Bladder cancer; BRCA cis rs6973256 0.828 rs10247014 chr7:133431038 A/C cg07491979 chr7:133331646 EXOC4 0.39 8.56 0.32 8.73e-17 Intelligence (multi-trait analysis); BRCA cis rs4730250 0.707 rs257375 chr7:106799043 A/G cg02696742 chr7:106810147 HBP1 -0.52 -8.41 -0.32 2.7e-16 Osteoarthritis; BRCA trans rs9858542 0.953 rs35261698 chr3:49537839 C/G cg21659725 chr3:3221576 CRBN -0.46 -9.91 -0.36 1.27e-21 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2243480 1.000 rs1873494 chr7:65649899 T/C cg18252515 chr7:66147081 NA 1.06 16.03 0.54 7.81e-49 Diabetic kidney disease; BRCA cis rs7582180 0.629 rs13025184 chr2:100944842 A/G cg14675211 chr2:100938903 LONRF2 0.52 11.62 0.42 1.9e-28 Intelligence (multi-trait analysis); BRCA cis rs17345786 1.000 rs58907984 chr3:101305170 T/G cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.58 12.63 0.45 8.71e-33 Colonoscopy-negative controls vs population controls; BRCA trans rs2797160 0.967 rs6910786 chr6:126017141 A/T cg05039488 chr6:79577232 IRAK1BP1 0.35 7.91 0.3 1.16e-14 Endometrial cancer; BRCA cis rs11098499 0.866 rs6857892 chr4:120282696 G/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs4595586 0.563 rs2388178 chr12:39364366 T/G cg26384229 chr12:38710491 ALG10B 0.42 9.36 0.35 1.34e-19 Morning vs. evening chronotype; BRCA cis rs1865760 0.593 rs9295678 chr6:25937033 G/A cg03264133 chr6:25882463 NA -0.37 -8.1 -0.31 2.85e-15 Height; BRCA cis rs7267979 1.000 rs4815412 chr20:25350325 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.37 0.35 1.22e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12310956 0.532 rs11052930 chr12:33964824 A/G cg06521331 chr12:34319734 NA -0.61 -11.11 -0.4 2.37e-26 Morning vs. evening chronotype; BRCA cis rs763121 0.853 rs5757193 chr22:39034867 A/G cg14440974 chr22:39074834 NA 0.41 9.26 0.34 3.1e-19 Menopause (age at onset); BRCA cis rs17685 0.558 rs60787921 chr7:75792844 C/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.42 -0.32 2.51e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4974559 0.501 rs1250129 chr4:1254930 C/T cg02980000 chr4:1222292 CTBP1 0.6 10.07 0.37 3.12e-22 Systolic blood pressure; BRCA cis rs921968 0.643 rs537520 chr2:219381852 A/G cg02176678 chr2:219576539 TTLL4 0.39 10.43 0.38 1.31e-23 Mean corpuscular hemoglobin concentration; BRCA cis rs507080 0.922 rs546890 chr11:118557198 T/C cg08498647 chr11:118550644 TREH -0.38 -8.26 -0.31 8.53e-16 Serum metabolite levels; BRCA cis rs6545883 0.929 rs7561229 chr2:61737990 A/T cg15711740 chr2:61764176 XPO1 -0.55 -14.14 -0.49 1.12e-39 Tuberculosis; BRCA cis rs7666738 0.830 rs6832209 chr4:98994120 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.59 0.39 2.87e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs58904263 1 rs58904263 chr20:30401406 A/AG cg21427119 chr20:30132790 HM13 -0.39 -8.27 -0.31 7.68e-16 Monocyte count; BRCA cis rs17376456 0.877 rs34595581 chr5:93369422 G/A cg25358565 chr5:93447407 FAM172A 1.21 18.4 0.59 5.64e-61 Diabetic retinopathy; BRCA cis rs12367572 0.620 rs1857925 chr12:45344385 T/C cg04608330 chr12:45269318 NELL2 -0.41 -8.53 -0.32 1.06e-16 Gut microbiome composition (summer); BRCA cis rs9400271 0.632 rs9372205 chr6:109588401 A/T cg01475377 chr6:109611718 NA -0.44 -10.4 -0.38 1.59e-23 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs12464559 0.522 rs4316939 chr2:152525120 C/T cg01189475 chr2:152685088 ARL5A -0.52 -8.0 -0.3 5.81e-15 Response to cognitive-behavioural therapy in anxiety disorder; BRCA cis rs4285028 0.948 rs12637351 chr3:121694412 A/G cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.62 0.39 2.33e-24 Multiple sclerosis; BRCA cis rs13031619 0.650 rs6542617 chr2:3694932 C/T cg10645314 chr2:3704589 ALLC 0.43 8.33 0.31 5.04e-16 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs34779708 0.931 rs11592404 chr10:35273476 G/A cg03585969 chr10:35415529 CREM 0.56 11.37 0.41 2.03e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs709400 0.628 rs1989565 chr14:103862193 G/A cg26031613 chr14:104095156 KLC1 -0.6 -12.71 -0.45 3.69e-33 Body mass index; BRCA cis rs7267979 1.000 rs6050602 chr20:25401203 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.66 -0.32 3.95e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 1.000 rs6657720 chr1:46386269 G/A cg06784218 chr1:46089804 CCDC17 0.45 10.84 0.39 2.92e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11249608 0.789 rs1969025 chr5:178425192 A/G cg21905437 chr5:178450457 ZNF879 0.4 8.4 0.32 2.99e-16 Pubertal anthropometrics; BRCA cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11890956 chr21:40555474 PSMG1 0.85 22.01 0.66 2.45e-80 Cognitive function; BRCA cis rs858239 0.509 rs6975524 chr7:23186452 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.64 0.39 1.8e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs250677 0.559 rs17109198 chr5:148369712 C/T cg12140854 chr5:148520817 ABLIM3 -0.41 -8.19 -0.31 1.38e-15 Breast cancer; BRCA cis rs4689388 0.890 rs4501291 chr4:6298582 C/T cg00701064 chr4:6280414 WFS1 0.71 19.54 0.61 5.18e-67 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs709400 0.930 rs2274268 chr14:104029378 C/G cg12935359 chr14:103987150 CKB -0.46 -10.38 -0.38 1.96e-23 Body mass index; BRCA cis rs6598955 0.543 rs57564009 chr1:26557618 A/T cg04990556 chr1:26633338 UBXN11 0.7 11.87 0.42 1.69e-29 Obesity-related traits; BRCA cis rs2762353 0.935 rs1359232 chr6:25809716 C/A cg03517284 chr6:25882590 NA 0.46 10.51 0.38 6.27e-24 Blood metabolite levels; BRCA cis rs28735056 0.565 rs12957336 chr18:77716889 A/G cg20368463 chr18:77673604 PQLC1 -0.36 -9.15 -0.34 7.8e-19 Schizophrenia; BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg15112475 chr7:1198522 ZFAND2A -0.4 -8.6 -0.32 5.94e-17 Longevity;Endometriosis; BRCA cis rs11997175 0.583 rs67830367 chr8:33833788 G/C ch.8.33884649F chr8:33765107 NA 0.35 7.89 0.3 1.29e-14 Body mass index; BRCA cis rs925228 0.504 rs7568272 chr2:24313785 T/C cg20701182 chr2:24300061 SF3B14 -0.52 -8.49 -0.32 1.49e-16 Reticulocyte fraction of red cells;Reticulocyte count; BRCA cis rs3125734 0.653 rs1007976 chr10:63970144 C/T cg09941381 chr10:64027924 RTKN2 0.29 8.57 0.32 7.83e-17 Rheumatoid arthritis; BRCA cis rs2011503 0.941 rs2315023 chr19:19413393 C/T cg11584989 chr19:19387371 SF4 0.65 14.16 0.49 8.89e-40 Bipolar disorder; BRCA cis rs2806561 0.894 rs1738475 chr1:23536891 C/G cg12483005 chr1:23474871 LUZP1 0.37 8.01 0.3 5.33e-15 Height; BRCA cis rs12618769 0.597 rs55978998 chr2:99049014 A/G cg10123293 chr2:99228465 UNC50 0.41 8.21 0.31 1.24e-15 Bipolar disorder; BRCA cis rs2710642 0.777 rs2539987 chr2:63142864 A/G cg17519650 chr2:63277830 OTX1 0.37 8.13 0.31 2.2e-15 LDL cholesterol levels;LDL cholesterol; BRCA cis rs1865760 0.566 rs9467663 chr6:26021456 C/G cg17691542 chr6:26056736 HIST1H1C 0.53 11.14 0.4 1.79e-26 Height; BRCA cis rs4566357 0.615 rs6436644 chr2:227914275 T/A cg11843606 chr2:227700838 RHBDD1 -0.42 -9.36 -0.35 1.32e-19 Coronary artery disease; BRCA cis rs7246657 0.722 rs8100646 chr19:38107943 T/C cg14683738 chr19:37701593 ZNF585B 0.47 8.18 0.31 1.53e-15 Coronary artery calcification; BRCA cis rs1552244 0.515 rs111560858 chr3:10166845 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.43 -0.35 7.61e-20 Alzheimer's disease; BRCA cis rs5758659 0.714 rs2284087 chr22:42485671 T/C cg04733989 chr22:42467013 NAGA -0.37 -8.22 -0.31 1.15e-15 Cognitive function; BRCA cis rs6912958 0.703 rs9362427 chr6:88097634 G/T cg12350822 chr6:88032061 C6orf162;GJB7 0.4 11.14 0.4 1.81e-26 Monocyte percentage of white cells; BRCA cis rs61931739 0.534 rs73103090 chr12:34098801 C/T cg06521331 chr12:34319734 NA -0.62 -11.36 -0.41 2.3e-27 Morning vs. evening chronotype; BRCA cis rs6088590 0.523 rs6058084 chr20:33183804 C/T cg06115741 chr20:33292138 TP53INP2 0.39 8.71 0.33 2.5e-17 Coronary artery disease; BRCA cis rs4819052 0.655 rs2330103 chr21:46694514 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.49 10.87 0.4 2.24e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4665809 1.000 rs7573118 chr2:26308086 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.64 -11.94 -0.43 7.99e-30 Gut microbiome composition (summer); BRCA cis rs801193 0.660 rs974239 chr7:66213491 G/A cg11764359 chr7:65958608 NA 0.79 18.45 0.59 3.04e-61 Aortic root size; BRCA cis rs55692411 0.517 rs62262106 chr3:49991427 A/G cg24110177 chr3:50126178 RBM5 -0.44 -9.79 -0.36 3.61e-21 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.954 rs11729521 chr4:120416788 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.87 -0.3 1.53e-14 Corneal astigmatism; BRCA trans rs208520 0.690 rs207112 chr6:66792092 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg01849466 chr14:104193079 ZFYVE21 -0.5 -12.91 -0.45 4.95e-34 Schizophrenia; BRCA cis rs17270561 0.609 rs1892255 chr6:25750354 G/A cg17691542 chr6:26056736 HIST1H1C 0.45 8.76 0.33 1.79e-17 Iron status biomarkers; BRCA cis rs10256972 0.539 rs2949174 chr7:1213923 T/C cg07092213 chr7:1199455 ZFAND2A -0.48 -10.07 -0.37 3.06e-22 Longevity;Endometriosis; BRCA cis rs7819412 0.594 rs17724226 chr8:10968926 C/T cg21775007 chr8:11205619 TDH -0.39 -7.82 -0.3 2.19e-14 Triglycerides; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.95 0.67 1.88e-85 Platelet count; BRCA cis rs1707322 0.721 rs10157795 chr1:46228192 G/A cg03146154 chr1:46216737 IPP 0.46 10.32 0.38 3.49e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3096299 0.933 rs889576 chr16:89429653 A/G cg06640241 chr16:89574553 SPG7 -0.53 -10.98 -0.4 8.24e-26 Multiple myeloma (IgH translocation); BRCA cis rs61931739 0.517 rs12816252 chr12:34067693 G/A cg06521331 chr12:34319734 NA -0.62 -11.14 -0.4 1.81e-26 Morning vs. evening chronotype; BRCA cis rs16866061 0.515 rs11695326 chr2:225415134 A/G cg22455342 chr2:225449267 CUL3 0.33 8.87 0.33 7.14e-18 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs875971 0.862 rs880166 chr7:65670762 T/C cg11764359 chr7:65958608 NA -0.76 -17.41 -0.57 7.52e-56 Aortic root size; BRCA cis rs10504229 0.683 rs79284841 chr8:58107611 T/A cg11062466 chr8:58055876 NA 0.57 9.5 0.35 4.18e-20 Developmental language disorder (linguistic errors); BRCA cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg06671706 chr8:8559999 CLDN23 0.45 8.63 0.32 4.86e-17 Obesity-related traits; BRCA cis rs7662987 0.517 rs2602845 chr4:100023944 T/C cg12011299 chr4:100065546 ADH4 0.48 10.87 0.4 2.26e-25 Smoking initiation; BRCA cis rs939658 0.935 rs12903747 chr15:79449627 A/C cg17916960 chr15:79447300 NA 0.39 9.84 0.36 2.23e-21 Refractive error; BRCA cis rs9790314 0.715 rs898681 chr3:160773098 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -9.01 -0.34 2.32e-18 Morning vs. evening chronotype; BRCA cis rs13108904 0.560 rs11247994 chr4:1343720 G/A cg01939980 chr4:1354348 KIAA1530 0.38 9.1 0.34 1.1e-18 Obesity-related traits; BRCA trans rs526821 0.595 rs4938937 chr11:55305507 T/A cg11707556 chr5:10655725 ANKRD33B -0.37 -8.21 -0.31 1.26e-15 Pediatric bone mineral density (spine); BRCA cis rs7267979 1.000 rs6115140 chr20:25285507 C/A cg08601574 chr20:25228251 PYGB 0.37 8.89 0.33 6.14e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11229555 0.645 rs11229457 chr11:58207203 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2842992 0.789 rs2475566 chr6:160148741 C/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 17.15 0.56 1.62e-54 Age-related macular degeneration (geographic atrophy); BRCA cis rs6089829 0.962 rs6089826 chr20:61668595 G/A cg08045932 chr20:61659980 NA 0.49 11.21 0.41 9.2e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs35000415 0.515 rs13240595 chr7:128731777 C/A cg02365945 chr7:128766374 LOC407835 -0.5 -7.87 -0.3 1.55e-14 Systemic lupus erythematosus; BRCA trans rs6089829 0.962 rs6062780 chr20:61666648 T/C cg15934090 chr1:100435551 SLC35A3 0.35 8.15 0.31 1.91e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7607369 0.714 rs1344643 chr2:219584975 G/C cg02176678 chr2:219576539 TTLL4 -0.46 -12.46 -0.44 4.79e-32 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs8062405 0.824 rs4788085 chr16:28535003 A/G cg16576597 chr16:28551801 NUPR1 0.28 7.9 0.3 1.26e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs34311866 0.808 rs3755958 chr4:963042 C/A cg07828340 chr4:882639 GAK 0.83 10.03 0.37 4.31e-22 Parkinson's disease; BRCA cis rs35110281 0.693 rs2251253 chr21:45092257 T/A cg04455712 chr21:45112962 RRP1B 0.44 11.96 0.43 6.83e-30 Mean corpuscular volume; BRCA cis rs9815354 0.680 rs73073250 chr3:42016559 G/T cg03022575 chr3:42003672 ULK4 0.75 9.65 0.36 1.17e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg22907277 chr7:1156413 C7orf50 0.62 10.73 0.39 8.53e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9287719 0.578 rs13425171 chr2:10731966 C/G cg00105475 chr2:10696890 NA 0.47 10.54 0.38 4.68e-24 Prostate cancer; BRCA cis rs2153535 0.580 rs9505455 chr6:8478622 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.68e-24 Motion sickness; BRCA cis rs10504229 1.000 rs67630725 chr8:58185580 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg19748678 chr4:122722346 EXOSC9 0.72 15.64 0.53 6.4e-47 Type 2 diabetes; BRCA cis rs6430585 0.528 rs309172 chr2:136674028 A/G cg07169764 chr2:136633963 MCM6 1.07 21.61 0.65 3.66e-78 Corneal structure; BRCA cis rs12142240 0.698 rs17361819 chr1:46828109 A/G cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.66e-15 Menopause (age at onset); BRCA cis rs2276314 1.000 rs4799832 chr18:33559646 T/C cg05985134 chr18:33552581 C18orf21 0.67 12.8 0.45 1.42e-33 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs17376456 0.877 rs13185660 chr5:93336500 G/A cg25358565 chr5:93447407 FAM172A 1.2 18.59 0.59 5.22e-62 Diabetic retinopathy; BRCA cis rs62064224 0.714 rs62064225 chr17:30635429 C/T cg25809561 chr17:30822961 MYO1D 0.4 9.52 0.35 3.4e-20 Schizophrenia; BRCA cis rs6952808 0.636 rs6964522 chr7:1953523 C/T cg02951883 chr7:2050386 MAD1L1 -0.38 -9.19 -0.34 5.5e-19 Bipolar disorder and schizophrenia; BRCA cis rs7589728 0.514 rs78204719 chr2:88460747 G/C cg14558114 chr2:88469736 THNSL2 0.6 8.89 0.33 6.31e-18 Plasma clusterin levels; BRCA cis rs1552244 1.000 rs7652935 chr3:10151138 T/C cg13047869 chr3:10149882 C3orf24 0.6 12.81 0.45 1.29e-33 Alzheimer's disease; BRCA cis rs7647973 0.677 rs11130211 chr3:49645209 C/T cg07636037 chr3:49044803 WDR6 0.56 9.16 0.34 7.19e-19 Menarche (age at onset); BRCA trans rs208520 0.661 rs704519 chr6:66801136 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -20.96 -0.64 1.29e-74 Exhaled nitric oxide output; BRCA cis rs3760982 0.585 rs11083724 chr19:44298988 A/G cg11993925 chr19:44307056 LYPD5 0.38 8.98 0.33 3e-18 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs35110281 0.627 rs1836855 chr21:44965414 C/G cg01579765 chr21:45077557 HSF2BP -0.36 -9.46 -0.35 5.62e-20 Mean corpuscular volume; BRCA cis rs7493 1.000 rs2286232 chr7:95039445 C/T cg01874867 chr7:94954059 PON1 -0.39 -8.07 -0.3 3.4e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs72781680 0.898 rs72786286 chr2:24074659 T/A cg20701182 chr2:24300061 SF3B14 0.58 9.0 0.34 2.58e-18 Lymphocyte counts; BRCA cis rs2991971 0.810 rs6657237 chr1:45920108 A/T cg24296786 chr1:45957014 TESK2 -0.56 -12.68 -0.45 5.03e-33 High light scatter reticulocyte count; BRCA cis rs9912789 0.807 rs9896850 chr17:79191726 C/T cg25342872 chr17:79175132 AZI1 -0.38 -9.26 -0.34 3.18e-19 Frontotemporal dementia; BRCA cis rs6952808 0.582 rs10479762 chr7:2045351 T/C cg03354898 chr7:1950403 MAD1L1 0.4 8.96 0.33 3.57e-18 Bipolar disorder and schizophrenia; BRCA cis rs4268898 0.662 rs2891380 chr2:24525830 G/A cg06627628 chr2:24431161 ITSN2 -0.78 -14.67 -0.5 3.27e-42 Asthma; BRCA cis rs739496 0.542 rs7316698 chr12:111790511 C/T cg10833066 chr12:111807467 FAM109A 0.35 8.1 0.31 2.77e-15 Platelet count; BRCA cis rs7301016 0.846 rs7302094 chr12:62967430 C/T cg01804193 chr12:63026212 NA 0.47 8.56 0.32 8.12e-17 IgG glycosylation; BRCA cis rs9811920 0.638 rs793440 chr3:99643176 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.32 -0.31 5.19e-16 Axial length; BRCA cis rs2274273 0.901 rs8011288 chr14:55735112 C/T cg04306507 chr14:55594613 LGALS3 0.29 8.08 0.3 3.29e-15 Protein biomarker; BRCA cis rs4665809 1.000 rs750451 chr2:26324241 G/A cg22920501 chr2:26401640 FAM59B -0.66 -11.51 -0.41 5.23e-28 Gut microbiome composition (summer); BRCA cis rs3760982 0.585 rs67773424 chr19:44293994 G/A cg11993925 chr19:44307056 LYPD5 0.37 8.76 0.33 1.79e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs2645694 0.533 rs2703125 chr4:77819900 T/C cg03477792 chr4:77819574 ANKRD56 0.66 15.57 0.52 1.47e-46 Emphysema distribution in smoking; BRCA cis rs6570726 0.791 rs418701 chr6:145889992 C/T cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.95e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6963495 0.818 rs55983796 chr7:105170941 C/T cg19920283 chr7:105172520 RINT1 0.59 9.53 0.35 3.29e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2439831 0.850 rs3825783 chr15:44102309 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.73 12.31 0.44 2.07e-31 Lung cancer in ever smokers; BRCA cis rs2070488 0.804 rs1817364 chr3:38474513 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.72 0.57 1.83e-57 Electrocardiographic conduction measures; BRCA cis rs2197308 0.667 rs61920838 chr12:37856814 T/C cg13010199 chr12:38710504 ALG10B -0.44 -9.52 -0.35 3.4e-20 Morning vs. evening chronotype; BRCA cis rs10504229 0.861 rs116964504 chr8:58185354 A/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs7552404 0.727 rs11161626 chr1:76260837 C/T cg03433033 chr1:76189801 ACADM 0.69 13.86 0.48 2.27e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs796364 0.806 rs79156935 chr2:200913822 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg04553112 chr3:125709451 NA -0.59 -9.23 -0.34 3.86e-19 Blood pressure (smoking interaction); BRCA cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.79e-68 Blood protein levels; BRCA cis rs10883723 0.773 rs1326193 chr10:104271674 G/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.41 0.59 4.72e-61 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7666738 0.830 rs4502686 chr4:98765117 T/C cg17366294 chr4:99064904 C4orf37 0.41 9.64 0.36 1.23e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs3862030 0.694 rs2025712 chr10:104230064 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.12e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs12887734 0.524 rs4906364 chr14:104214342 C/G cg08213375 chr14:104286397 PPP1R13B 0.52 11.47 0.41 7.91e-28 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA trans rs61931739 0.500 rs11053274 chr12:34547605 G/A cg26384229 chr12:38710491 ALG10B 0.72 16.05 0.54 5.93e-49 Morning vs. evening chronotype; BRCA cis rs9649213 0.593 rs6465673 chr7:97968887 C/T cg24562669 chr7:97807699 LMTK2 0.44 11.7 0.42 8.61e-29 Prostate cancer (SNP x SNP interaction); BRCA trans rs11976180 1.000 rs2371244 chr7:143757611 A/T cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.44 -8.09 -0.3 2.97e-15 Obesity-related traits; BRCA cis rs367943 0.608 rs4705463 chr5:112980273 C/G cg12552261 chr5:112820674 MCC 0.37 8.03 0.3 4.77e-15 Type 2 diabetes; BRCA cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg06238570 chr21:40685208 BRWD1 0.43 8.78 0.33 1.51e-17 Cognitive function; BRCA cis rs28735056 1.000 rs28865701 chr18:77620911 A/G cg03682112 chr18:77623598 KCNG2 -0.37 -8.62 -0.32 5.3e-17 Schizophrenia; BRCA cis rs13256369 1.000 rs12545771 chr8:8567977 C/G cg17143192 chr8:8559678 CLDN23 0.55 10.48 0.38 8.13e-24 Obesity-related traits; BRCA cis rs6089829 0.962 rs6122350 chr20:61664617 A/G cg03213289 chr20:61660250 NA 0.63 16.54 0.55 2.05e-51 Prostate cancer (SNP x SNP interaction); BRCA cis rs11190604 1.000 rs10883502 chr10:102238343 T/G cg07080220 chr10:102295463 HIF1AN 0.49 11.34 0.41 2.78e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2742234 0.590 rs2503864 chr10:43666767 G/T cg15436174 chr10:43711423 RASGEF1A -0.54 -10.93 -0.4 1.28e-25 Hirschsprung disease; BRCA cis rs6061231 0.724 rs1570027 chr20:60968596 A/G cg22633769 chr20:60982531 CABLES2 0.44 7.94 0.3 8.85e-15 Colorectal cancer; BRCA cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs17376456 0.877 rs2085960 chr5:93399934 A/G cg25358565 chr5:93447407 FAM172A 1.21 19.0 0.6 3.95e-64 Diabetic retinopathy; BRCA cis rs4820294 1.000 rs713835 chr22:38064650 C/T cg21798802 chr22:38057573 PDXP 0.49 13.18 0.46 2.91e-35 Fat distribution (HIV); BRCA cis rs7772486 0.846 rs9376976 chr6:146355605 T/C cg13319975 chr6:146136371 FBXO30 -0.37 -8.44 -0.32 2.09e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs9399135 0.660 rs4440481 chr6:135276696 A/G cg24558204 chr6:135376177 HBS1L 0.47 12.8 0.45 1.49e-33 Red blood cell count; BRCA cis rs4713675 0.565 rs942640 chr6:33686442 G/T cg14003231 chr6:33640908 ITPR3 0.35 8.7 0.33 2.91e-17 Plateletcrit; BRCA cis rs34779708 0.931 rs7897457 chr10:35386040 A/G cg03585969 chr10:35415529 CREM 0.5 10.46 0.38 9.76e-24 Inflammatory bowel disease;Crohn's disease; BRCA trans rs3960554 0.808 rs111764601 chr7:75706141 T/C cg19862616 chr7:65841803 NCRNA00174 0.61 12.5 0.44 3.23e-32 Eotaxin levels; BRCA cis rs10129255 0.536 rs6576223 chr14:107184687 C/T cg07958169 chr14:107095056 NA -0.39 -8.41 -0.32 2.66e-16 Kawasaki disease; BRCA cis rs4642101 0.561 rs9812144 chr3:12805910 G/A cg24848339 chr3:12840334 CAND2 0.38 9.25 0.34 3.44e-19 QRS complex (12-leadsum); BRCA cis rs9287719 0.674 rs11684157 chr2:10827157 C/A cg00105475 chr2:10696890 NA -0.38 -8.75 -0.33 1.89e-17 Prostate cancer; BRCA cis rs10256972 0.713 rs10435026 chr7:1065948 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -10.46 -0.38 1e-23 Longevity;Endometriosis; BRCA cis rs4853036 0.951 rs10165061 chr2:70146363 C/T cg02498382 chr2:70120550 SNRNP27 -0.51 -10.07 -0.37 3.17e-22 Colorectal or endometrial cancer; BRCA cis rs798554 0.757 rs960273 chr7:2857876 T/C cg19346786 chr7:2764209 NA -0.31 -8.92 -0.33 4.73e-18 Height; BRCA cis rs7762018 0.660 rs78181018 chr6:170096652 A/C cg19338460 chr6:170058176 WDR27 -0.74 -9.66 -0.36 1.08e-20 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs7715806 0.500 rs17563700 chr5:74986045 A/G cg19683494 chr5:74908142 NA 0.52 8.46 0.32 1.87e-16 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2011503 1.000 rs2011503 chr19:19443986 C/T cg15839431 chr19:19639596 YJEFN3 -0.4 -8.83 -0.33 1.02e-17 Bipolar disorder; BRCA cis rs1865760 0.613 rs9358894 chr6:25923315 C/T cg16482183 chr6:26056742 HIST1H1C 0.37 7.82 0.3 2.23e-14 Height; BRCA cis rs17376456 0.825 rs10054903 chr5:93281491 C/A cg21475434 chr5:93447410 FAM172A 0.67 8.73 0.33 2.21e-17 Diabetic retinopathy; BRCA cis rs4665809 0.590 rs10495756 chr2:26485586 A/G cg27170947 chr2:26402098 FAM59B 0.97 17.18 0.56 1.18e-54 Gut microbiome composition (summer); BRCA cis rs9733 0.596 rs72702580 chr1:150691285 A/T cg18016565 chr1:150552671 MCL1 0.34 8.07 0.3 3.57e-15 Tonsillectomy; BRCA trans rs561341 1.000 rs117029332 chr17:30266085 C/G cg20587970 chr11:113659929 NA -1.35 -24.3 -0.69 7.04e-93 Hip circumference adjusted for BMI; BRCA cis rs495337 1.000 rs4810998 chr20:48580010 G/C cg17835207 chr20:48524531 SPATA2 -0.61 -14.14 -0.49 1.12e-39 Psoriasis; BRCA cis rs9814567 1.000 rs13071551 chr3:134310867 C/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.63 0.32 4.73e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6430585 0.527 rs62168792 chr2:136415217 A/G cg07169764 chr2:136633963 MCM6 1.0 19.54 0.61 5.29e-67 Corneal structure; BRCA cis rs897984 0.683 rs729482 chr16:31016970 T/C cg02466173 chr16:30829666 NA -0.43 -9.19 -0.34 5.62e-19 Dementia with Lewy bodies; BRCA cis rs4363385 0.720 rs1611764 chr1:152957887 G/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.44 -0.32 2.09e-16 Inflammatory skin disease; BRCA cis rs6665290 0.901 rs61834005 chr1:227202789 C/T cg10327440 chr1:227177885 CDC42BPA -1.09 -40.16 -0.85 6.44e-177 Myeloid white cell count; BRCA cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg13770153 chr20:60521292 NA -0.44 -9.93 -0.37 1.06e-21 Body mass index; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg04944784 chr2:26401820 FAM59B -0.67 -11.17 -0.4 1.34e-26 Gut microbiome composition (summer); BRCA cis rs2425143 1.000 rs1118233 chr20:34228349 T/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.64 -0.32 4.53e-17 Blood protein levels; BRCA cis rs703842 1.000 rs1599932 chr12:58177943 G/A cg00677455 chr12:58241039 CTDSP2 0.63 14.18 0.49 7.02e-40 Multiple sclerosis; BRCA cis rs921968 0.613 rs556497 chr2:219446477 G/A cg02176678 chr2:219576539 TTLL4 0.4 10.88 0.4 2.09e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs3917254 0.543 rs6752379 chr2:102746705 G/A cg22835712 chr2:102737379 NA -0.53 -9.33 -0.35 1.65e-19 Blood protein levels; BRCA cis rs7584330 0.554 rs6760913 chr2:238400702 C/T cg08992911 chr2:238395768 MLPH 0.57 9.41 0.35 9e-20 Prostate cancer; BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00149659 chr3:10157352 C3orf10 0.8 13.78 0.48 5.12e-38 Alzheimer's disease; BRCA cis rs11229555 0.645 rs10896814 chr11:58430699 T/C cg15696309 chr11:58395628 NA -0.43 -8.96 -0.33 3.4e-18 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9790314 0.586 rs11713185 chr3:161111357 C/G cg04691961 chr3:161091175 C3orf57 -0.38 -8.95 -0.33 3.84e-18 Morning vs. evening chronotype; BRCA cis rs3099143 1.000 rs7174048 chr15:77165416 T/C cg21673338 chr15:77095150 SCAPER 0.53 9.5 0.35 4.3e-20 Recalcitrant atopic dermatitis; BRCA cis rs10751667 0.961 rs7395928 chr11:952605 T/G cg10932868 chr11:921992 NA 0.39 9.41 0.35 9.17e-20 Alzheimer's disease (late onset); BRCA cis rs13191362 0.507 rs2846566 chr6:163059714 G/A cg21926612 chr6:163149169 PACRG;PARK2 -0.55 -10.48 -0.38 8.33e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs225245 0.817 rs225299 chr17:33922742 T/C cg19694781 chr19:47549865 TMEM160 -0.32 -7.81 -0.3 2.38e-14 Reticulocyte count;Reticulocyte fraction of red cells;High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells; BRCA cis rs700590 0.515 rs62380364 chr5:88107337 C/A cg22951263 chr5:87985283 NA -0.35 -8.89 -0.33 6.39e-18 Educational attainment (years of education); BRCA cis rs6496044 0.568 rs1982742 chr15:86068750 A/G cg10818794 chr15:86012489 AKAP13 -0.29 -8.0 -0.3 5.67e-15 Interstitial lung disease; BRCA trans rs9393777 0.920 rs41269265 chr6:27425349 T/C cg06606381 chr12:133084897 FBRSL1 -0.71 -7.96 -0.3 7.63e-15 Intelligence (multi-trait analysis); BRCA cis rs2991971 1.000 rs518365 chr1:46010652 A/G cg15605315 chr1:45957053 TESK2 0.47 9.49 0.35 4.47e-20 High light scatter reticulocyte count; BRCA cis rs8114671 0.562 rs4911161 chr20:33402231 C/T cg24642439 chr20:33292090 TP53INP2 0.42 8.87 0.33 7.22e-18 Height; BRCA cis rs7537052 0.669 rs2296263 chr1:36641729 C/T cg24686825 chr1:36642396 MAP7D1 -0.53 -12.07 -0.43 2.35e-30 Schizophrenia; BRCA cis rs7959452 0.649 rs4761239 chr12:69776886 T/A cg22834771 chr12:69754056 YEATS4 -0.37 -8.9 -0.33 5.66e-18 Blood protein levels; BRCA cis rs703842 1.000 rs2069502 chr12:58144665 A/G cg00677455 chr12:58241039 CTDSP2 -0.59 -13.03 -0.46 1.38e-34 Multiple sclerosis; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA cis rs798554 0.757 rs1182172 chr7:2878103 G/A cg13628971 chr7:2884303 GNA12 0.49 9.56 0.35 2.54e-20 Height; BRCA cis rs9443645 0.901 rs2050662 chr6:79753073 G/C cg18132916 chr6:79620363 NA -0.5 -11.4 -0.41 1.62e-27 Intelligence (multi-trait analysis); BRCA cis rs798554 0.721 rs2527680 chr7:2892361 C/T cg14863265 chr7:2801509 GNA12 -0.48 -10.46 -0.38 9.32e-24 Height; BRCA cis rs2070488 0.775 rs13098946 chr3:38517784 C/G cg24069376 chr3:38537580 EXOG 0.34 9.28 0.34 2.49e-19 Electrocardiographic conduction measures; BRCA cis rs5750830 0.649 rs5750814 chr22:39797987 T/C cg24399712 chr22:39784796 NA -0.58 -13.4 -0.47 2.79e-36 Intelligence (multi-trait analysis); BRCA cis rs477692 0.673 rs1078847 chr10:131352115 T/C cg05714579 chr10:131428358 MGMT 0.5 11.06 0.4 3.8e-26 Response to temozolomide; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg10729496 chr3:10149963 C3orf24 0.49 9.41 0.35 8.99e-20 Alzheimer's disease; BRCA trans rs11098499 0.909 rs28793658 chr4:120307214 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs3767633 0.925 rs10753666 chr1:161861147 C/G cg09175582 chr1:161736000 ATF6 0.53 8.67 0.32 3.69e-17 IgG glycosylation; BRCA cis rs4073582 0.595 rs801737 chr11:65928193 T/C cg14036092 chr11:66035641 RAB1B 0.39 10.77 0.39 5.9e-25 Gout; BRCA cis rs4665809 0.941 rs41285975 chr2:26351144 T/C cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.68 -0.42 1.08e-28 Gut microbiome composition (summer); BRCA trans rs6479891 1.000 rs7087279 chr10:65291936 T/A cg14819942 chr15:35414228 NA -0.32 -8.17 -0.31 1.66e-15 Arthritis (juvenile idiopathic); BRCA cis rs10193935 0.901 rs62142596 chr2:42529339 C/T cg27598129 chr2:42591480 NA -0.65 -10.94 -0.4 1.19e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1113500 0.933 rs4590700 chr1:108638344 G/T cg06207961 chr1:108661230 NA 0.45 11.09 0.4 2.84e-26 Growth-regulated protein alpha levels; BRCA cis rs919433 0.713 rs2045245 chr2:198485341 A/C cg00792783 chr2:198669748 PLCL1 0.37 8.35 0.31 4.25e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9790314 0.638 rs62280303 chr3:160647891 G/A cg03342759 chr3:160939853 NMD3 0.45 8.73 0.33 2.19e-17 Morning vs. evening chronotype; BRCA cis rs1865721 1.000 rs17283454 chr18:73186619 G/A cg26385618 chr18:73139727 C18orf62 -0.4 -9.16 -0.34 6.89e-19 Intelligence; BRCA cis rs10504229 0.775 rs17805074 chr8:58161048 C/T cg11062466 chr8:58055876 NA -0.49 -8.48 -0.32 1.53e-16 Developmental language disorder (linguistic errors); BRCA cis rs55883249 1.000 rs62119423 chr2:9726601 C/T cg23886495 chr2:9695866 ADAM17 0.56 7.97 0.3 7.16e-15 3-hydroxy-1-methylpropylmercapturic acid levels in smokers; BRCA cis rs10504229 0.953 rs67677367 chr8:58175264 T/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs6089584 0.526 rs6061965 chr20:60607858 A/C cg13770153 chr20:60521292 NA -0.34 -7.96 -0.3 8.08e-15 Body mass index; BRCA cis rs13118159 0.872 rs4974605 chr4:1346389 C/G cg01939980 chr4:1354348 KIAA1530 0.29 7.97 0.3 7.57e-15 Longevity; BRCA cis rs7927592 0.956 rs12274114 chr11:68255577 A/C cg20283391 chr11:68216788 NA -0.45 -9.32 -0.35 1.81e-19 Total body bone mineral density; BRCA cis rs10479542 0.784 rs7703730 chr5:178986632 C/A cg26516362 chr5:178986906 RUFY1 -0.43 -12.33 -0.44 1.71e-31 Lung cancer; BRCA cis rs2404602 0.647 rs11629727 chr15:77009038 G/C cg23625390 chr15:77176239 SCAPER -0.55 -13.15 -0.46 3.96e-35 Blood metabolite levels; BRCA cis rs6701037 0.748 rs11585368 chr1:175135448 G/A cg00321850 chr1:175162397 KIAA0040 -0.42 -11.63 -0.42 1.79e-28 Alcohol dependence; BRCA trans rs1493916 0.748 rs7230463 chr18:31309133 G/C cg27147174 chr7:100797783 AP1S1 -0.43 -8.84 -0.33 9.26e-18 Life satisfaction; BRCA cis rs6964587 0.934 rs4512319 chr7:91733829 G/A cg17063962 chr7:91808500 NA 0.57 12.51 0.44 2.88e-32 Breast cancer; BRCA cis rs11098499 0.955 rs1511018 chr4:120161580 G/T cg09307838 chr4:120376055 NA 0.63 12.73 0.45 3.08e-33 Corneal astigmatism; BRCA trans rs11098499 0.739 rs7441137 chr4:120133221 G/T cg25214090 chr10:38739885 LOC399744 -0.46 -9.84 -0.36 2.35e-21 Corneal astigmatism; BRCA trans rs208515 0.525 rs10944870 chr6:66687757 G/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.03 0.54 7.38e-49 Exhaled nitric oxide levels; BRCA cis rs921968 0.565 rs6757772 chr2:219618497 T/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.07 -0.4 3.65e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs12142240 0.698 rs1057535 chr1:46815898 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs796364 1.000 rs281785 chr2:200749566 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.91 0.45 4.89e-34 Schizophrenia; BRCA trans rs1493916 0.837 rs9945976 chr18:31409314 C/T cg15819921 chr19:927150 ARID3A -0.41 -8.07 -0.3 3.37e-15 Life satisfaction; BRCA cis rs4285028 0.747 rs9820511 chr3:121361345 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.69 -13.56 -0.47 5.51e-37 Multiple sclerosis; BRCA cis rs9486715 0.867 rs3860243 chr6:96905303 T/G cg06623918 chr6:96969491 KIAA0776 0.87 24.33 0.69 5.11e-93 Headache; BRCA trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA trans rs10506458 0.834 rs73125186 chr12:63373400 C/T cg22491629 chr6:157744540 C6orf35 -0.61 -11.1 -0.4 2.56e-26 Hemostatic factors and hematological phenotypes; BRCA cis rs7520050 0.778 rs3013597 chr1:46128356 C/A cg24296786 chr1:45957014 TESK2 -0.46 -10.6 -0.39 2.74e-24 Red blood cell count;Reticulocyte count; BRCA cis rs7395581 0.959 rs7120118 chr11:47286290 T/C cg25783544 chr11:47291846 MADD 0.42 9.34 0.35 1.61e-19 HDL cholesterol; BRCA cis rs4148883 0.675 rs28762430 chr4:100119257 C/A cg12011299 chr4:100065546 ADH4 0.39 10.27 0.38 5.43e-23 Alcohol dependence; BRCA cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg16339924 chr4:17578868 LAP3 0.62 15.44 0.52 5.95e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs17345786 0.906 rs11708616 chr3:101231731 C/T cg12386194 chr3:101231763 SENP7 0.67 13.29 0.47 8.98e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs6754311 0.517 rs60453613 chr2:136527120 G/C cg07169764 chr2:136633963 MCM6 0.99 20.24 0.63 9.27e-71 Mosquito bite size; BRCA cis rs11599315 0.507 rs12220555 chr10:1341858 C/T cg27336068 chr10:1336103 ADARB2 -0.29 -7.99 -0.3 6.44e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA trans rs9858542 0.953 rs1873625 chr3:49666964 C/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.4 -9.55 -0.35 2.63e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9486719 1.000 rs2179126 chr6:96871350 A/G cg06623918 chr6:96969491 KIAA0776 0.73 13.03 0.46 1.46e-34 Migraine;Coronary artery disease; BRCA cis rs9649213 0.593 rs6947208 chr7:97912204 C/T cg24562669 chr7:97807699 LMTK2 0.45 12.01 0.43 4.11e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs57221529 0.766 rs17563576 chr5:560476 A/G cg09021430 chr5:549028 NA -0.67 -15.45 -0.52 5.36e-46 Lung disease severity in cystic fibrosis; BRCA cis rs61990749 0.597 rs12896026 chr14:78244436 A/G cg02301378 chr14:78227641 SNW1;C14orf178 0.57 9.27 0.34 2.92e-19 Fibroblast growth factor basic levels; BRCA cis rs6952808 0.692 rs56727870 chr7:2029940 T/C cg18279126 chr7:2041391 MAD1L1 0.37 8.21 0.31 1.22e-15 Bipolar disorder and schizophrenia; BRCA cis rs27434 0.583 rs34762 chr5:96153966 A/G cg16492584 chr5:96139282 ERAP1 -0.51 -12.82 -0.45 1.2e-33 Ankylosing spondylitis; BRCA cis rs250677 0.687 rs36046 chr5:148441257 A/C cg23229984 chr5:148520753 ABLIM3 0.36 8.89 0.33 6.37e-18 Breast cancer; BRCA cis rs6088580 0.567 rs6088520 chr20:33132364 A/G cg08999081 chr20:33150536 PIGU -0.44 -11.91 -0.43 1.09e-29 Glomerular filtration rate (creatinine); BRCA cis rs6860806 0.631 rs4705931 chr5:131588345 T/C cg18758796 chr5:131593413 PDLIM4 0.36 9.47 0.35 5.21e-20 Breast cancer; BRCA cis rs9420 0.961 rs12805841 chr11:57443842 G/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.51 -0.44 2.91e-32 Schizophrenia; BRCA cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg11663144 chr21:46675770 NA -0.51 -10.16 -0.37 1.46e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10504229 0.953 rs6990806 chr8:58183113 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs6088580 0.624 rs6120645 chr20:33025171 C/T cg24642439 chr20:33292090 TP53INP2 0.54 11.73 0.42 6.53e-29 Glomerular filtration rate (creatinine); BRCA cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.53 10.01 0.37 5.17e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs561341 0.941 rs4525554 chr17:30312819 T/C cg20587970 chr11:113659929 NA -1.2 -22.15 -0.66 4.31e-81 Hip circumference adjusted for BMI; BRCA cis rs6484504 0.553 rs7113880 chr11:31279557 A/G cg14844989 chr11:31128820 NA -0.44 -9.78 -0.36 3.87e-21 Red blood cell count; BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg18598329 chr3:10140678 FANCD2;C3orf24 0.62 10.33 0.38 3.17e-23 Alzheimer's disease; BRCA cis rs9733 0.596 rs6686525 chr1:150635811 C/T cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs56104184 0.779 rs17206686 chr19:49356317 A/G cg15549821 chr19:49342101 PLEKHA4 -0.93 -15.24 -0.52 5.85e-45 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs7618915 0.501 rs34739010 chr3:52766122 A/G cg10802521 chr3:52805072 NEK4 -0.34 -9.41 -0.35 8.52e-20 Bipolar disorder; BRCA cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg10802521 chr3:52805072 NEK4 -0.33 -9.13 -0.34 8.81e-19 Bipolar disorder; BRCA cis rs7572733 0.515 rs1401096 chr2:198823828 A/G cg00792783 chr2:198669748 PLCL1 0.45 9.9 0.36 1.36e-21 Dermatomyositis; BRCA cis rs10876993 0.928 rs1689592 chr12:58057773 C/T cg18357645 chr12:58087776 OS9 0.46 13.45 0.47 1.66e-36 Celiac disease or Rheumatoid arthritis; BRCA cis rs425277 0.606 rs12082939 chr1:2078922 C/T cg04315214 chr1:2043799 PRKCZ -0.44 -11.91 -0.43 1.16e-29 Height; BRCA cis rs10256972 0.869 rs4720158 chr7:1040325 A/G cg16145915 chr7:1198662 ZFAND2A -0.37 -8.45 -0.32 1.91e-16 Longevity;Endometriosis; BRCA trans rs4650994 0.935 rs4652306 chr1:178528206 T/C cg05059571 chr16:84539110 KIAA1609 -0.41 -9.22 -0.34 4.12e-19 HDL cholesterol levels;HDL cholesterol; BRCA cis rs35110281 0.659 rs2236667 chr21:45112939 A/G cg01579765 chr21:45077557 HSF2BP -0.44 -12.0 -0.43 4.63e-30 Mean corpuscular volume; BRCA cis rs4423214 0.798 rs1894100 chr11:71130343 G/T cg05163923 chr11:71159392 DHCR7 -0.53 -10.34 -0.38 2.79e-23 Vitamin D levels; BRCA cis rs8177253 0.930 rs12595 chr3:133496553 T/C cg12373951 chr3:133503437 NA 0.45 10.43 0.38 1.27e-23 Iron status biomarkers; BRCA cis rs60843830 1.000 rs56321614 chr2:268191 G/T cg25945732 chr2:264204 ACP1;SH3YL1 0.8 19.79 0.62 2.41e-68 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9486719 1.000 rs12207570 chr6:96987884 A/C cg06623918 chr6:96969491 KIAA0776 -0.75 -13.73 -0.48 8.62e-38 Migraine;Coronary artery disease; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg00149659 chr3:10157352 C3orf10 0.71 12.33 0.44 1.69e-31 Alzheimer's disease; BRCA cis rs829883 0.664 rs1096148 chr12:98851005 A/G cg25150519 chr12:98850993 NA 0.68 16.4 0.54 1.01e-50 Colorectal adenoma (advanced); BRCA cis rs7666738 0.822 rs11097599 chr4:98959562 T/A cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2120243 0.874 rs2316709 chr3:157150247 C/T cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.51 0.35 3.96e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs10504229 0.775 rs17805026 chr8:58160637 A/C cg22535103 chr8:58192502 C8orf71 -0.49 -8.6 -0.32 5.95e-17 Developmental language disorder (linguistic errors); BRCA cis rs2242116 1.000 rs2168443 chr3:46947087 A/T cg02527881 chr3:46936655 PTH1R 0.4 10.22 0.37 8.23e-23 Birth weight; BRCA cis rs35110281 0.600 rs914198 chr21:45117456 A/C cg04455712 chr21:45112962 RRP1B 0.43 11.25 0.41 6.33e-27 Mean corpuscular volume; BRCA cis rs559928 0.606 rs11231726 chr11:63987339 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.45 0.41 9.34e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs12142240 0.698 rs17357676 chr1:46812444 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs67981189 0.593 rs2810101 chr14:71429827 G/C cg15816911 chr14:71606274 NA -0.36 -8.25 -0.31 8.79e-16 Schizophrenia; BRCA cis rs13082711 0.522 rs640065 chr3:27363937 A/T cg02860705 chr3:27208620 NA 0.39 7.92 0.3 1.05e-14 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs4819052 0.851 rs2838828 chr21:46663423 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.52 9.91 0.37 1.21e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7677751 0.806 rs4864862 chr4:55100489 G/A cg17187183 chr4:55093834 PDGFRA 0.43 8.84 0.33 9.59e-18 Corneal astigmatism; BRCA cis rs16958440 0.867 rs80064497 chr18:44669653 A/G cg17192377 chr18:44677553 HDHD2 0.99 13.87 0.48 1.94e-38 Sitting height ratio; BRCA cis rs832540 0.603 rs6870175 chr5:56093371 A/G cg24549020 chr5:56110836 MAP3K1 0.39 8.18 0.31 1.54e-15 Coronary artery disease; BRCA cis rs798554 0.660 rs1182175 chr7:2875026 C/T cg19717773 chr7:2847554 GNA12 0.41 9.23 0.34 3.88e-19 Height; BRCA trans rs11098499 0.569 rs55845118 chr4:120290913 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA trans rs1814175 0.754 rs7103235 chr11:49699191 A/G cg15704280 chr7:45808275 SEPT13 -0.84 -20.44 -0.63 7.5e-72 Height; BRCA cis rs523522 0.885 rs524735 chr12:121022099 T/C cg27279351 chr12:120934652 DYNLL1 0.56 13.4 0.47 3.06e-36 High light scatter reticulocyte count; BRCA cis rs12477438 0.765 rs12470471 chr2:99689141 A/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.56 12.27 0.44 3.24e-31 Chronic sinus infection; BRCA cis rs9790314 0.663 rs9811594 chr3:160745935 A/G cg03342759 chr3:160939853 NMD3 -0.44 -9.09 -0.34 1.22e-18 Morning vs. evening chronotype; BRCA cis rs7511006 0.893 rs5771104 chr22:50651839 C/T cg16473166 chr22:50639996 SELO 0.52 11.72 0.42 7.26e-29 Obesity-related traits; BRCA cis rs300703 0.542 rs300691 chr2:180171 C/A cg21211680 chr2:198530 NA -0.37 -8.18 -0.31 1.59e-15 Blood protein levels; BRCA cis rs2304069 0.954 rs1469691 chr5:149386716 G/A cg10852222 chr5:149380144 HMGXB3;TIGD6 0.56 8.71 0.33 2.65e-17 HIV-1 control; BRCA cis rs782590 0.935 rs782568 chr2:55881538 T/C cg18811423 chr2:55921094 PNPT1 0.75 25.14 0.71 1.71e-97 Metabolic syndrome; BRCA cis rs66731853 0.769 rs530104 chr1:20895721 A/G cg04087271 chr1:20915334 CDA -0.47 -9.43 -0.35 7.72e-20 Mean corpuscular volume; BRCA cis rs11051970 0.636 rs1128591 chr12:32569351 T/C cg02745156 chr12:32552066 NA 0.25 8.38 0.31 3.42e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs11098499 0.954 rs11098525 chr4:120390152 G/A cg09307838 chr4:120376055 NA 0.75 16.2 0.54 1.03e-49 Corneal astigmatism; BRCA cis rs561341 1.000 rs501957 chr17:30314504 C/T cg23018236 chr17:30244563 NA -0.58 -9.59 -0.35 1.96e-20 Hip circumference adjusted for BMI; BRCA cis rs514406 0.929 rs562178 chr1:53319562 T/C cg25767906 chr1:53392781 SCP2 -0.39 -8.92 -0.33 4.93e-18 Monocyte count; BRCA cis rs2404602 0.536 rs12915248 chr15:76765615 A/T cg22467129 chr15:76604101 ETFA -0.47 -10.57 -0.39 3.6e-24 Blood metabolite levels; BRCA cis rs1511802 0.666 rs4862662 chr4:187118662 A/C cg24794857 chr4:187113578 CYP4V2 -0.36 -7.92 -0.3 1.03e-14 Blood protein levels; BRCA cis rs757110 0.770 rs11024268 chr11:17387982 A/G cg04705435 chr11:17411270 KCNJ11 0.43 9.33 0.35 1.66e-19 Type 2 diabetes; BRCA cis rs611744 0.647 rs585077 chr8:109245497 C/T cg21045802 chr8:109455806 TTC35 0.36 8.11 0.31 2.65e-15 Dupuytren's disease; BRCA cis rs13102973 0.863 rs11099307 chr4:135908104 T/C cg14419869 chr4:135874104 NA 0.45 9.0 0.34 2.46e-18 Subjective well-being; BRCA cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg06697600 chr4:7070879 GRPEL1 -0.55 -10.99 -0.4 7.36e-26 Monocyte percentage of white cells; BRCA cis rs798554 0.644 rs1639040 chr7:2884116 G/T cg13628971 chr7:2884303 GNA12 0.57 11.99 0.43 5.13e-30 Height; BRCA cis rs1129187 0.967 rs9462857 chr6:42943098 T/C cg13397359 chr6:42928475 GNMT 0.75 19.37 0.61 3.96e-66 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11764590 0.724 rs62444917 chr7:2107262 A/C cg02951883 chr7:2050386 MAD1L1 0.39 8.11 0.31 2.62e-15 Neuroticism; BRCA cis rs11229555 0.645 rs12803648 chr11:58177561 G/T cg15696309 chr11:58395628 NA -0.45 -9.68 -0.36 9.19e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6456156 0.586 rs6456150 chr6:167468922 A/G cg07741184 chr6:167504864 NA 0.33 9.87 0.36 1.8e-21 Primary biliary cholangitis; BRCA cis rs2108225 0.934 rs2283045 chr7:107440714 G/A cg18560240 chr7:107437656 SLC26A3 -0.55 -11.58 -0.42 2.84e-28 Ulcerative colitis; BRCA cis rs1420338 0.967 rs10272282 chr7:34172073 C/T cg01275685 chr7:34179230 BMPER -0.46 -9.95 -0.37 8.47e-22 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs10465746 0.746 rs12749350 chr1:84456948 T/A cg10977910 chr1:84465055 TTLL7 0.57 12.01 0.43 4.32e-30 Obesity-related traits; BRCA trans rs7829975 0.711 rs4841051 chr8:8685646 C/T cg16141378 chr3:129829833 LOC729375 0.31 8.08 0.3 3.16e-15 Mood instability; BRCA cis rs67478160 0.643 rs3742369 chr14:104251276 T/C cg26031613 chr14:104095156 KLC1 -0.45 -8.84 -0.33 9.49e-18 Schizophrenia; BRCA cis rs9309711 0.666 rs4321399 chr2:3481659 G/A cg15506890 chr2:3487001 NA -0.53 -11.75 -0.42 5.53e-29 Neurofibrillary tangles; BRCA cis rs881375 0.715 rs10760119 chr9:123646060 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 11.19 0.4 1.15e-26 Rheumatoid arthritis; BRCA cis rs751728 0.689 rs3763257 chr6:33773696 T/A cg25922239 chr6:33757077 LEMD2 0.52 11.64 0.42 1.52e-28 Crohn's disease; BRCA cis rs4718428 0.705 rs3800817 chr7:66263550 T/A cg18252515 chr7:66147081 NA -0.53 -10.92 -0.4 1.37e-25 Corneal structure; BRCA cis rs17345786 0.798 rs1609159 chr3:101275902 A/C cg11279151 chr3:101281821 RG9MTD1 -0.61 -13.96 -0.48 7.68e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs1018836 0.923 rs10956749 chr8:91621573 G/A cg16814680 chr8:91681699 NA -0.6 -12.8 -0.45 1.46e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs921968 0.541 rs7601872 chr2:219319885 C/G cg10223061 chr2:219282414 VIL1 0.3 8.57 0.32 7.87e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs1707322 0.650 rs4553239 chr1:46150486 C/A cg03146154 chr1:46216737 IPP 0.54 12.0 0.43 4.61e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1129187 0.755 rs3293 chr6:42938377 G/T cg27588902 chr6:42928151 GNMT -0.3 -10.04 -0.37 4.18e-22 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1865760 0.663 rs9348704 chr6:26000393 A/C cg17691542 chr6:26056736 HIST1H1C 0.49 10.41 0.38 1.51e-23 Height; BRCA cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg22800045 chr5:56110881 MAP3K1 0.62 11.73 0.42 6.59e-29 Initial pursuit acceleration; BRCA cis rs6964587 0.773 rs2097810 chr7:91977226 G/A cg01689657 chr7:91764605 CYP51A1 0.23 7.81 0.3 2.36e-14 Breast cancer; BRCA cis rs4665809 0.590 rs6730310 chr2:26419470 C/G cg26119090 chr2:26468346 HADHA;HADHB -1.05 -21.07 -0.64 2.96e-75 Gut microbiome composition (summer); BRCA cis rs4332037 0.624 rs11764124 chr7:1891723 C/G cg12432903 chr7:1882776 MAD1L1 0.45 8.03 0.3 4.55e-15 Bipolar disorder; BRCA cis rs72781680 1.000 rs56104215 chr2:24133590 T/C cg08917208 chr2:24149416 ATAD2B 0.94 14.03 0.49 3.44e-39 Lymphocyte counts; BRCA cis rs769267 0.965 rs2905425 chr19:19475717 G/C cg02546618 chr19:19431379 KIAA0892;SF4 -0.37 -8.83 -0.33 1e-17 Tonsillectomy; BRCA cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg14558114 chr2:88469736 THNSL2 -0.41 -8.97 -0.33 3.25e-18 Response to metformin (IC50); BRCA cis rs311392 1.000 rs454064 chr8:55088336 C/T cg11783602 chr8:55087084 NA -0.33 -9.59 -0.35 1.94e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs7572733 0.534 rs13026569 chr2:198783330 C/G cg00792783 chr2:198669748 PLCL1 -0.46 -9.98 -0.37 7.05e-22 Dermatomyositis; BRCA cis rs2303759 0.874 rs10411630 chr19:49891314 C/A cg24324837 chr19:49891574 CCDC155 0.57 10.38 0.38 1.9e-23 Multiple sclerosis; BRCA cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.53 -11.93 -0.43 9.31e-30 Personality dimensions; BRCA cis rs4665809 0.938 rs6742226 chr2:26342537 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.62 -11.59 -0.42 2.42e-28 Gut microbiome composition (summer); BRCA cis rs11955398 0.716 rs12515025 chr5:59999437 G/A cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.42e-19 Intelligence (multi-trait analysis); BRCA cis rs4423214 0.879 rs1792284 chr11:71134966 A/G cg05163923 chr11:71159392 DHCR7 0.55 10.91 0.4 1.6e-25 Vitamin D levels; BRCA cis rs765787 0.530 rs11070445 chr15:45513163 T/A cg25801113 chr15:45476975 SHF -0.33 -8.31 -0.31 5.63e-16 Uric acid levels; BRCA cis rs1568889 1.000 rs34337978 chr11:28136746 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 13.49 0.47 1.18e-36 Bipolar disorder; BRCA cis rs2153535 0.580 rs763376 chr6:8492776 G/A cg21535247 chr6:8435926 SLC35B3 0.42 9.64 0.36 1.22e-20 Motion sickness; BRCA cis rs6831352 0.918 rs29001216 chr4:100051556 A/T cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs12618769 0.597 rs3769724 chr2:99105981 C/T cg10123293 chr2:99228465 UNC50 0.42 8.22 0.31 1.18e-15 Bipolar disorder; BRCA cis rs738322 0.967 rs133013 chr22:38570912 C/T cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA cis rs6860806 1.000 rs6860806 chr5:131640536 C/T cg14196790 chr5:131705035 SLC22A5 -0.38 -10.22 -0.37 8.5e-23 Breast cancer; BRCA cis rs9733 0.596 rs12072339 chr1:150686099 A/G cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs6570726 1.000 rs951143 chr6:145932576 C/T cg23711669 chr6:146136114 FBXO30 0.63 14.12 0.49 1.38e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs4363385 0.747 rs946100 chr1:152971663 C/T cg21543102 chr1:152974771 SPRR3 0.29 8.19 0.31 1.42e-15 Inflammatory skin disease; BRCA cis rs10751667 0.643 rs10902238 chr11:944810 G/A cg01483505 chr11:975446 AP2A2 0.3 8.21 0.31 1.18e-15 Alzheimer's disease (late onset); BRCA cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg11166453 chr1:247681781 NA 0.41 9.3 0.35 2.23e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs7586673 0.930 rs7591506 chr2:161960925 T/G cg22496339 chr2:162101262 NA 0.44 9.04 0.34 1.9e-18 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.641 rs9390374 chr6:146368175 A/T cg05347473 chr6:146136440 FBXO30 0.56 10.79 0.39 4.63e-25 Lobe attachment (rater-scored or self-reported); BRCA cis rs61931739 0.517 rs10772139 chr12:34186178 A/T cg06521331 chr12:34319734 NA -0.63 -11.57 -0.42 2.98e-28 Morning vs. evening chronotype; BRCA cis rs490234 0.775 rs12341245 chr9:128340941 C/T cg14078157 chr9:128172775 NA -0.46 -10.5 -0.38 6.48e-24 Mean arterial pressure; BRCA cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg13010199 chr12:38710504 ALG10B 0.54 11.79 0.42 3.61e-29 Heart rate; BRCA cis rs12760731 0.777 rs6701080 chr1:178382261 A/C cg00404053 chr1:178313656 RASAL2 0.7 8.36 0.31 3.81e-16 Obesity-related traits; BRCA cis rs2991971 0.967 rs6661321 chr1:45954599 C/G cg15605315 chr1:45957053 TESK2 0.5 10.31 0.38 3.72e-23 High light scatter reticulocyte count; BRCA cis rs17641971 0.862 rs341829 chr8:50005758 T/C cg00325661 chr8:49890786 NA -0.29 -7.83 -0.3 2.06e-14 Blood metabolite levels; BRCA cis rs1975974 0.872 rs66502681 chr17:21722119 T/A cg18423549 chr17:21743878 NA -0.53 -11.27 -0.41 5.49e-27 Psoriasis; BRCA cis rs61935443 0.614 rs11107787 chr12:95311669 C/T cg21533806 chr12:95267307 NA 0.46 8.17 0.31 1.65e-15 Schizophrenia; BRCA cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs7618915 0.501 rs13085775 chr3:52678370 C/T cg10802521 chr3:52805072 NEK4 -0.34 -9.16 -0.34 7e-19 Bipolar disorder; BRCA cis rs11920090 0.858 rs10513688 chr3:170727218 G/A cg09710316 chr3:170744871 SLC2A2 0.52 8.97 0.33 3.39e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs2625529 0.824 rs2306488 chr15:72292115 A/G cg16672083 chr15:72433130 SENP8 -0.86 -17.68 -0.57 3.02e-57 Red blood cell count; BRCA cis rs7044106 0.762 rs10818471 chr9:123394045 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.82 0.42 2.77e-29 Hip circumference adjusted for BMI; BRCA cis rs9733 0.818 rs11204702 chr1:150663507 C/A cg13175981 chr1:150552382 MCL1 0.48 10.62 0.39 2.16e-24 Tonsillectomy; BRCA cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg04398451 chr17:18023971 MYO15A -0.52 -11.34 -0.41 2.69e-27 Total body bone mineral density; BRCA cis rs6987853 0.787 rs12677427 chr8:42414226 T/A cg09913449 chr8:42400586 C8orf40 0.42 9.38 0.35 1.11e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs13046373 0.535 rs2832964 chr21:32014012 A/C cg22337977 chr21:31811175 KRTAP15-1 0.33 7.83 0.3 2e-14 HDL cholesterol; BRCA cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.62 13.2 0.46 2.36e-35 Age-related macular degeneration (geographic atrophy); BRCA cis rs1707322 1.000 rs7553924 chr1:46352624 T/C cg03146154 chr1:46216737 IPP 0.45 9.95 0.37 8.9e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6973256 0.897 rs10954422 chr7:133327587 G/A cg07491979 chr7:133331646 EXOC4 -0.39 -8.84 -0.33 9.14e-18 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.869 rs1007766 chr7:1034903 G/A cg16145915 chr7:1198662 ZFAND2A -0.41 -9.04 -0.34 1.91e-18 Longevity;Endometriosis; BRCA cis rs60871478 0.898 rs35928069 chr7:823067 G/C cg05535760 chr7:792225 HEATR2 0.7 12.34 0.44 1.65e-31 Cerebrospinal P-tau181p levels; BRCA cis rs8141529 0.673 rs132548 chr22:29317559 C/G cg15103426 chr22:29168792 CCDC117 -0.51 -11.95 -0.43 7.84e-30 Lymphocyte counts; BRCA cis rs911555 0.755 rs975892 chr14:103883349 A/T cg24130564 chr14:104152367 KLC1 -0.36 -8.2 -0.31 1.33e-15 Intelligence (multi-trait analysis); BRCA cis rs6815814 0.861 rs10034903 chr4:38784678 C/G cg06935464 chr4:38784597 TLR10 0.48 9.52 0.35 3.58e-20 Breast cancer; BRCA cis rs6005807 0.719 rs73430168 chr22:28985428 C/T cg12565055 chr22:29076175 TTC28 0.51 9.49 0.35 4.32e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs2710642 0.962 rs1828398 chr2:63034870 A/G cg17519650 chr2:63277830 OTX1 -0.38 -8.4 -0.32 2.91e-16 LDL cholesterol levels;LDL cholesterol; BRCA cis rs35306767 0.761 rs11253540 chr10:1011958 C/T cg26597838 chr10:835615 NA -0.99 -15.4 -0.52 9.31e-46 Eosinophil percentage of granulocytes; BRCA cis rs870825 0.655 rs7675046 chr4:185652201 G/A cg04058563 chr4:185651563 MLF1IP -0.73 -15.84 -0.53 6.2e-48 Blood protein levels; BRCA cis rs9816226 0.618 rs1516728 chr3:185829891 A/T cg00760338 chr3:185826511 ETV5 0.56 12.28 0.44 2.8e-31 Obesity;Body mass index; BRCA cis rs9325144 0.560 rs61929893 chr12:38653366 G/A cg13010199 chr12:38710504 ALG10B -0.39 -8.83 -0.33 1.04e-17 Morning vs. evening chronotype; BRCA cis rs561341 0.882 rs72825748 chr17:30367396 G/A cg12193833 chr17:30244370 NA -0.6 -9.04 -0.34 1.89e-18 Hip circumference adjusted for BMI; BRCA cis rs7586879 0.796 rs916486 chr2:25082629 C/A cg04586622 chr2:25135609 ADCY3 0.37 8.99 0.34 2.74e-18 Body mass index; BRCA cis rs921968 0.643 rs611203 chr2:219472325 G/A cg02176678 chr2:219576539 TTLL4 0.42 11.39 0.41 1.76e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs873946 0.504 rs3829132 chr10:134579044 A/C cg27286337 chr10:134555280 INPP5A 0.67 12.12 0.43 1.43e-30 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs698833 0.892 rs2603257 chr2:44731588 T/A cg18685995 chr2:44588913 PREPL;C2orf34 0.51 10.03 0.37 4.51e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs13256369 0.826 rs7846050 chr8:8575669 A/G cg18904891 chr8:8559673 CLDN23 0.55 10.84 0.39 3.09e-25 Obesity-related traits; BRCA cis rs6088590 1.000 rs6088615 chr20:33400474 C/T cg06115741 chr20:33292138 TP53INP2 -0.49 -11.04 -0.4 4.9e-26 Coronary artery disease; BRCA cis rs780096 0.526 rs4803 chr2:27667297 A/G cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.57 -0.35 2.31e-20 Total body bone mineral density; BRCA cis rs10791323 0.569 rs10750553 chr11:133740251 T/C cg06766960 chr11:133703094 NA -0.45 -10.26 -0.38 5.88e-23 Childhood ear infection; BRCA cis rs936229 0.861 rs12441505 chr15:75107311 A/C cg10253484 chr15:75165896 SCAMP2 -0.49 -9.62 -0.36 1.46e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.768 rs351752 chr6:109536034 C/A cg01475377 chr6:109611718 NA -0.42 -10.54 -0.38 4.75e-24 Reticulocyte fraction of red cells; BRCA cis rs67478160 0.643 rs11626377 chr14:104234357 G/A cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.2 -0.41 1.02e-26 Schizophrenia; BRCA cis rs7552404 0.731 rs1770885 chr1:76402212 C/T cg10523679 chr1:76189770 ACADM -0.54 -10.06 -0.37 3.44e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6964587 0.839 rs13229273 chr7:91444472 G/A cg17063962 chr7:91808500 NA 0.5 11.32 0.41 3.27e-27 Breast cancer; BRCA cis rs11229555 0.645 rs1986404 chr11:58194614 T/C cg15696309 chr11:58395628 NA -0.52 -10.87 -0.4 2.25e-25 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs6964587 0.967 rs6974827 chr7:91772945 C/T cg17063962 chr7:91808500 NA 0.6 14.47 0.5 2.89e-41 Breast cancer; BRCA cis rs17376456 0.877 rs10055741 chr5:93297187 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.88 0.6 1.53e-63 Diabetic retinopathy; BRCA cis rs6484504 0.576 rs286653 chr11:31227824 C/T cg26647111 chr11:31128758 NA -0.45 -9.78 -0.36 3.99e-21 Red blood cell count; BRCA cis rs4891159 0.548 rs2554830 chr18:74127702 A/G cg24786174 chr18:74118243 ZNF516 0.84 25.79 0.71 4.4e-101 Longevity; BRCA cis rs12586317 0.513 rs17102962 chr14:35478782 A/T cg05294307 chr14:35346193 BAZ1A -0.59 -10.36 -0.38 2.26e-23 Psoriasis; BRCA cis rs2153535 0.580 rs9406163 chr6:8466642 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.72 0.36 6.31e-21 Menopause (age at onset); BRCA cis rs524281 0.861 rs10896094 chr11:65959206 C/T cg16950941 chr11:66035639 RAB1B -0.38 -7.96 -0.3 7.71e-15 Electroencephalogram traits; BRCA cis rs35740288 0.862 rs11637444 chr15:86311188 G/A cg20737812 chr15:86336631 KLHL25 -0.33 -8.1 -0.31 2.7e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs10504229 0.775 rs72650876 chr8:58161638 G/A cg08219700 chr8:58056026 NA 0.54 8.85 0.33 8.66e-18 Developmental language disorder (linguistic errors); BRCA cis rs5760092 0.618 rs5996631 chr22:24256894 T/C cg12419862 chr22:24373484 LOC391322 0.64 12.78 0.45 1.77e-33 Urinary 1,3-butadiene metabolite levels in smokers; BRCA cis rs11676348 0.755 rs13410318 chr2:219022910 T/G cg20019365 chr2:219134978 PNKD;AAMP 0.44 9.24 0.34 3.51e-19 Ulcerative colitis; BRCA cis rs13191362 0.935 rs73008456 chr6:163013697 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.95 0.46 3.16e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11608355 0.545 rs6606721 chr12:109891999 G/A cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs796364 0.616 rs2030653 chr2:200677625 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 0.51 8.33 0.31 4.96e-16 Schizophrenia; BRCA cis rs9291683 0.551 rs2276961 chr4:10022981 C/T cg11266682 chr4:10021025 SLC2A9 0.5 13.24 0.46 1.63e-35 Bone mineral density; BRCA trans rs526821 0.595 rs629948 chr11:55356448 G/A cg11707556 chr5:10655725 ANKRD33B -0.36 -8.08 -0.3 3.19e-15 Pediatric bone mineral density (spine); BRCA cis rs7246967 0.673 rs3853649 chr19:22880460 C/G cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs61931739 0.500 rs7955247 chr12:34126580 G/A cg06521331 chr12:34319734 NA -0.62 -11.26 -0.41 5.68e-27 Morning vs. evening chronotype; BRCA cis rs875971 0.660 rs801190 chr7:66033033 C/T cg11764359 chr7:65958608 NA -0.68 -15.39 -0.52 1.07e-45 Aortic root size; BRCA cis rs4722585 0.533 rs3753097 chr7:26198207 A/G cg07876897 chr7:26191696 NFE2L3 0.41 8.78 0.33 1.48e-17 Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy);Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 1 peripheral neuropathy); BRCA cis rs7903847 0.642 rs7074511 chr10:99140177 G/A cg20016023 chr10:99160130 RRP12 -0.27 -8.59 -0.32 6.68e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg26608667 chr7:1196370 ZFAND2A 0.38 9.18 0.34 5.92e-19 Longevity;Endometriosis; BRCA cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg05623727 chr3:50126028 RBM5 0.41 9.7 0.36 7.31e-21 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs35727620 chr2:26458364 G/A cg25036284 chr2:26402008 FAM59B 0.88 15.06 0.51 4.18e-44 Gut microbiome composition (summer); BRCA cis rs826838 0.935 rs980571 chr12:39127532 C/G cg13010199 chr12:38710504 ALG10B -0.44 -10.29 -0.38 4.39e-23 Heart rate; BRCA cis rs7772486 0.790 rs2253654 chr6:146199445 T/C cg13319975 chr6:146136371 FBXO30 -0.44 -10.14 -0.37 1.67e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs2732480 0.557 rs2732441 chr12:48723324 C/G cg04545296 chr12:48745243 ZNF641 0.25 8.18 0.31 1.52e-15 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs6964587 1.000 rs7802668 chr7:91648939 A/G cg17063962 chr7:91808500 NA 0.53 12.59 0.45 1.21e-32 Breast cancer; BRCA cis rs4302748 0.909 rs1882062 chr7:36188719 C/T cg24442661 chr7:36192818 EEPD1 0.47 8.59 0.32 6.56e-17 Platelet count; BRCA cis rs6748734 1.000 rs11898716 chr2:241828311 A/G cg02820040 chr2:241836501 C2orf54 -0.53 -10.19 -0.37 1.03e-22 Urinary metabolites; BRCA cis rs9467773 1.000 rs2393670 chr6:26535541 A/G cg11502198 chr6:26597334 ABT1 0.47 9.44 0.35 6.67e-20 Intelligence (multi-trait analysis); BRCA cis rs7264396 0.690 rs2425171 chr20:34443173 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.45 -0.52 5.35e-46 Total cholesterol levels; BRCA cis rs6541297 1.000 rs6541297 chr1:230283506 G/A cg20703242 chr1:230279135 GALNT2 0.46 10.22 0.37 8.51e-23 Coronary artery disease; BRCA cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.75e-16 Menopause (age at onset); BRCA cis rs919433 0.817 rs10931780 chr2:198175297 G/C cg03934865 chr2:198174659 NA -0.45 -9.89 -0.36 1.52e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs887829 0.588 rs4663969 chr2:234655313 C/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.35 -9.33 -0.35 1.73e-19 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs7666738 0.791 rs1593571 chr4:98963763 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.94e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs8062405 0.965 rs56040780 chr16:28861881 C/T cg16576597 chr16:28551801 NUPR1 0.29 8.24 0.31 1e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs6121246 0.909 rs1994249 chr20:30287593 C/T cg21427119 chr20:30132790 HM13 -0.42 -8.85 -0.33 8.22e-18 Mean corpuscular hemoglobin; BRCA cis rs68170813 0.559 rs12538769 chr7:106984288 C/T cg02696742 chr7:106810147 HBP1 -0.56 -8.92 -0.33 4.72e-18 Coronary artery disease; BRCA cis rs765787 0.505 rs12593605 chr15:45497448 T/A cg25801113 chr15:45476975 SHF -0.34 -8.14 -0.31 2.08e-15 Uric acid levels; BRCA cis rs9858542 0.953 rs9859556 chr3:49455986 G/T cg07274523 chr3:49395745 GPX1 0.46 7.88 0.3 1.38e-14 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs7939886 0.920 rs7115395 chr11:55877116 G/A cg15704280 chr7:45808275 SEPT13 0.61 7.98 0.3 6.74e-15 Myopia (pathological); BRCA trans rs7395662 0.786 rs12791074 chr11:49005023 G/A cg00717180 chr2:96193071 NA -0.31 -8.65 -0.32 4.19e-17 HDL cholesterol; BRCA trans rs11252926 0.527 rs10904093 chr10:436848 A/G cg00953403 chr17:74099816 EXOC7 -0.52 -9.7 -0.36 7.7e-21 Psychosis in Alzheimer's disease; BRCA cis rs1829883 0.798 rs2049313 chr5:98802976 T/G cg08333243 chr5:99726346 NA -0.35 -7.82 -0.3 2.24e-14 Hemostatic factors and hematological phenotypes; BRCA cis rs10911251 0.546 rs7473 chr1:183114634 G/A ch.1.3577855R chr1:183094577 LAMC1 0.65 16.69 0.55 3.69e-52 Colorectal cancer; BRCA cis rs6942756 0.774 rs2694574 chr7:128908963 A/G cg02491457 chr7:128862824 NA 0.58 12.28 0.44 2.74e-31 White matter hyperintensity burden; BRCA cis rs3008870 0.959 rs2815359 chr1:67494374 T/C cg08660285 chr1:67390436 MIER1;WDR78 0.97 21.57 0.65 6.18e-78 Lymphocyte percentage of white cells; BRCA cis rs1143633 0.530 rs4538207 chr2:113701863 G/T cg12858261 chr2:113808755 IL1F8 0.35 7.86 0.3 1.59e-14 Allergic disease (asthma, hay fever or eczema); BRCA cis rs68170813 0.559 rs7794965 chr7:106826439 A/G cg02696742 chr7:106810147 HBP1 0.52 8.87 0.33 7.14e-18 Coronary artery disease; BRCA cis rs6963495 0.818 rs73190167 chr7:105160418 A/G cg19920283 chr7:105172520 RINT1 0.59 9.54 0.35 2.83e-20 Bipolar disorder (body mass index interaction); BRCA cis rs13064411 0.696 rs7619913 chr3:113017503 A/G cg18753928 chr3:113234510 CCDC52 -0.45 -8.35 -0.31 4.19e-16 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs60871478 0.541 rs56964970 chr7:910791 G/C cg27478167 chr7:817139 HEATR2 0.5 9.71 0.36 7.05e-21 Cerebrospinal P-tau181p levels; BRCA cis rs6860806 0.531 rs272887 chr5:131665713 A/G cg09877947 chr5:131593287 PDLIM4 0.36 7.84 0.3 1.91e-14 Breast cancer; BRCA cis rs9790314 0.846 rs7652267 chr3:160998497 A/G cg03342759 chr3:160939853 NMD3 -0.71 -18.04 -0.58 4.35e-59 Morning vs. evening chronotype; BRCA cis rs3857067 0.772 rs4438731 chr4:95091384 A/G cg11021082 chr4:95130006 SMARCAD1 -0.39 -9.35 -0.35 1.41e-19 QT interval; BRCA cis rs2839186 0.709 rs2156117 chr21:47669300 C/A cg08742575 chr21:47604166 C21orf56 0.41 8.3 0.31 5.98e-16 Testicular germ cell tumor; BRCA cis rs12611088 0.602 rs6509092 chr19:44022305 A/T cg13740135 chr19:44006432 PHLDB3 -0.3 -7.88 -0.3 1.39e-14 Plasma amyloid beta peptide concentrations (ABx-42); BRCA cis rs9443645 0.838 rs9350800 chr6:79729489 A/C cg11833968 chr6:79620685 NA -0.44 -9.86 -0.36 2e-21 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs56196593 chr8:58141898 G/A cg08219700 chr8:58056026 NA 0.46 8.3 0.31 6.17e-16 Developmental language disorder (linguistic errors); BRCA cis rs2836974 0.897 rs34035316 chr21:40594023 T/C cg11890956 chr21:40555474 PSMG1 1.05 30.2 0.77 3.5e-125 Cognitive function; BRCA cis rs798554 0.757 rs1182176 chr7:2874601 A/G cg19346786 chr7:2764209 NA -0.29 -8.8 -0.33 1.25e-17 Height; BRCA cis rs3096299 0.617 rs2353030 chr16:89405827 C/T cg00750074 chr16:89608354 SPG7 0.3 8.23 0.31 1.06e-15 Multiple myeloma (IgH translocation); BRCA cis rs11874712 1.000 rs8088881 chr18:43664970 T/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.18 0.31 1.57e-15 Migraine - clinic-based; BRCA cis rs921968 0.541 rs588770 chr2:219494638 T/C cg10223061 chr2:219282414 VIL1 -0.28 -8.16 -0.31 1.78e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs9443645 0.901 rs1354831 chr6:79613576 T/C cg18132916 chr6:79620363 NA -0.47 -10.71 -0.39 9.62e-25 Intelligence (multi-trait analysis); BRCA cis rs6121246 0.909 rs6089070 chr20:30377773 A/G cg13852791 chr20:30311386 BCL2L1 -0.75 -12.38 -0.44 1.03e-31 Mean corpuscular hemoglobin; BRCA cis rs733175 0.855 rs6853437 chr4:10005435 A/G cg00071950 chr4:10020882 SLC2A9 -0.4 -8.46 -0.32 1.79e-16 Psychosis and Alzheimer's disease; BRCA cis rs365132 0.905 rs353463 chr5:176403170 A/C cg16309518 chr5:176445507 NA -0.4 -9.78 -0.36 3.77e-21 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs73001065 0.901 rs73004926 chr19:19671266 C/T cg03709012 chr19:19516395 GATAD2A 0.85 9.47 0.35 5.14e-20 LDL cholesterol; BRCA cis rs55692411 0.517 rs13095697 chr3:50136463 G/A cg14019146 chr3:50243930 SLC38A3 -0.56 -11.43 -0.41 1.2100000000000001e-27 Intelligence (multi-trait analysis); BRCA cis rs2404602 0.622 rs4886506 chr15:77207277 G/T cg23625390 chr15:77176239 SCAPER 0.52 12.79 0.45 1.62e-33 Blood metabolite levels; BRCA cis rs2204008 0.665 rs11495668 chr12:38221018 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5.33e-22 Bladder cancer; BRCA cis rs4953076 0.573 rs2053456 chr2:44448632 G/A cg04920474 chr2:44395004 PPM1B 0.5 10.0 0.37 5.77e-22 Height; BRCA cis rs4722166 0.598 rs4722178 chr7:22798650 T/C cg05472934 chr7:22766657 IL6 0.39 9.65 0.36 1.15e-20 Lung cancer; BRCA cis rs9649213 0.593 rs6465675 chr7:97982103 C/T cg01877450 chr7:97915802 BRI3 0.39 8.71 0.33 2.68e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.76 -19.03 -0.6 2.58e-64 Systemic lupus erythematosus; BRCA cis rs2239547 0.563 rs9839035 chr3:52909877 C/T cg11645453 chr3:52864694 ITIH4 0.47 10.97 0.4 8.77e-26 Schizophrenia; BRCA cis rs3741404 0.672 rs4980524 chr11:63959259 A/C cg18225595 chr11:63971243 STIP1 0.42 10.62 0.39 2.31e-24 Platelet count; BRCA cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg17892150 chr10:133769511 PPP2R2D -0.72 -15.45 -0.52 5.26e-46 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg18404041 chr3:52824283 ITIH1 -0.44 -12.76 -0.45 2.31e-33 Bipolar disorder; BRCA cis rs4243830 0.850 rs2063806 chr1:6610382 C/T cg22792644 chr1:6614718 TAS1R1;NOL9 -0.89 -17.62 -0.57 6.1e-57 Body mass index; BRCA cis rs7523273 0.597 rs11118612 chr1:207979577 T/A cg22525895 chr1:207977042 MIR29B2 -0.41 -8.57 -0.32 7.67e-17 Schizophrenia; BRCA cis rs10189230 0.967 rs10498113 chr2:222352629 C/T cg14652038 chr2:222343519 EPHA4 0.46 12.85 0.45 9.04e-34 Urate levels in lean individuals; BRCA cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg00339695 chr16:24857497 SLC5A11 -0.53 -11.3 -0.41 3.87e-27 Intelligence (multi-trait analysis); BRCA cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg18876405 chr7:65276391 NA 0.55 13.29 0.47 9.4e-36 Aortic root size; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg25036284 chr2:26402008 FAM59B -0.61 -10.28 -0.38 4.8e-23 Gut microbiome composition (summer); BRCA cis rs4589502 0.512 rs7183242 chr15:67096658 A/G cg09911534 chr15:67153556 NA -0.5 -10.16 -0.37 1.44e-22 Lung cancer (smoking interaction); BRCA cis rs4363385 0.791 rs3120744 chr1:153010330 G/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.05e-17 Inflammatory skin disease; BRCA cis rs1003719 0.628 rs2835635 chr21:38528866 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.58 -13.72 -0.48 1e-37 Eye color traits; BRCA cis rs270601 0.661 rs10036208 chr5:131571323 T/C cg24060327 chr5:131705240 SLC22A5 -0.41 -7.84 -0.3 1.84e-14 Acylcarnitine levels; BRCA cis rs1113500 0.814 rs1592282 chr1:108601365 T/C cg06207961 chr1:108661230 NA 0.34 8.13 0.31 2.27e-15 Growth-regulated protein alpha levels; BRCA cis rs12541635 0.677 rs1429681 chr8:107048808 A/C cg10147462 chr8:107024639 NA 0.4 10.68 0.39 1.33e-24 Age of smoking initiation; BRCA cis rs10504229 1.000 rs57941207 chr8:58169821 A/G cg14926445 chr8:58193284 C8orf71 -0.46 -8.7 -0.33 2.73e-17 Developmental language disorder (linguistic errors); BRCA cis rs873946 0.504 rs3793681 chr10:134564451 T/C cg18305652 chr10:134549665 INPP5A 0.51 13.27 0.46 1.18e-35 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs56104184 0.775 rs73061692 chr19:49399676 T/C cg21252483 chr19:49399788 TULP2 -0.51 -10.82 -0.39 3.49e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs10751667 0.560 rs10902265 chr11:1003642 G/A cg01483505 chr11:975446 AP2A2 0.31 8.41 0.32 2.65e-16 Alzheimer's disease (late onset); BRCA cis rs9487051 0.676 rs9386774 chr6:109561646 C/T cg21918786 chr6:109611834 NA -0.32 -8.25 -0.31 9.15e-16 Reticulocyte fraction of red cells; BRCA cis rs2439831 0.850 rs3816792 chr15:44116986 A/G cg27015174 chr15:43622946 ADAL;LCMT2 -0.45 -8.81 -0.33 1.22e-17 Lung cancer in ever smokers; BRCA cis rs4862750 0.914 rs1991255 chr4:187875340 G/A cg11301795 chr4:187892539 NA -0.31 -10.26 -0.38 6.01e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs1843834 0.539 rs6739735 chr2:225405253 A/G cg22509189 chr2:225307070 NA 0.47 9.94 0.37 9.63e-22 IgE levels in asthmatics (D.p. specific); BRCA cis rs7666738 0.830 rs9995386 chr4:98907826 T/C cg05340658 chr4:99064831 C4orf37 0.62 15.07 0.51 3.71e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.667 rs9941787 chr21:45116042 A/G cg21573476 chr21:45109991 RRP1B -0.41 -10.56 -0.39 3.83e-24 Mean corpuscular volume; BRCA cis rs7582180 0.764 rs7425797 chr2:100928337 T/C cg14675211 chr2:100938903 LONRF2 0.5 11.42 0.41 1.35e-27 Intelligence (multi-trait analysis); BRCA cis rs870825 0.929 rs10027213 chr4:185579871 C/G cg04058563 chr4:185651563 MLF1IP 0.67 12.07 0.43 2.41e-30 Blood protein levels; BRCA cis rs6952808 0.531 rs3778991 chr7:2172455 G/A cg05863683 chr7:1912471 MAD1L1 0.39 8.05 0.3 4.01e-15 Bipolar disorder and schizophrenia; BRCA cis rs6598955 0.671 rs13374173 chr1:26602256 T/G cg00852783 chr1:26633632 UBXN11 -0.46 -8.1 -0.31 2.88e-15 Obesity-related traits; BRCA trans rs3857536 0.505 rs208459 chr6:66911055 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.56 -10.4 -0.38 1.65e-23 Blood trace element (Cu levels); BRCA cis rs1552244 1.000 rs35993975 chr3:10067794 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.67 -10.86 -0.39 2.42e-25 Alzheimer's disease; BRCA cis rs600806 0.850 rs10858095 chr1:109962642 G/C cg20591472 chr1:110008990 SYPL2 0.34 8.46 0.32 1.88e-16 Intelligence (multi-trait analysis); BRCA cis rs2115630 1.000 rs8037423 chr15:85355494 C/T cg12863693 chr15:85201151 NMB -0.36 -8.39 -0.32 3.11e-16 P wave terminal force; BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg01262667 chr19:19385393 TM6SF2 0.41 10.75 0.39 6.82e-25 Tonsillectomy; BRCA cis rs875971 1.000 rs6946143 chr7:65579722 A/C cg18876405 chr7:65276391 NA 0.56 13.43 0.47 2.22e-36 Aortic root size; BRCA cis rs6700896 0.931 rs7531867 chr1:66107546 A/G cg04111102 chr1:66153794 NA -0.34 -8.53 -0.32 1.03e-16 C-reactive protein;Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs12142240 0.698 rs55670684 chr1:46835139 C/T cg00530320 chr1:46809349 NSUN4 0.47 9.3 0.35 2.21e-19 Menopause (age at onset); BRCA cis rs9527 0.590 rs2182348 chr10:104872684 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.13e-24 Arsenic metabolism; BRCA cis rs9814567 1.000 rs4423809 chr3:134300107 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.45 0.61 1.5e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1003719 0.680 rs3992 chr21:38505969 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs7552404 0.690 rs7549863 chr1:76327923 T/C cg22875332 chr1:76189707 ACADM -0.52 -10.14 -0.37 1.6400000000000001e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3772130 1.000 rs2070180 chr3:121351338 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.52 -9.14 -0.34 8.05e-19 Cognitive performance; BRCA cis rs10782582 0.532 rs12132503 chr1:76137762 C/G cg03433033 chr1:76189801 ACADM -0.46 -9.6 -0.36 1.71e-20 Daytime sleep phenotypes; BRCA cis rs9393692 0.905 rs9379838 chr6:26277133 C/T cg13736514 chr6:26305472 NA -0.35 -11.82 -0.42 2.62e-29 Educational attainment; BRCA cis rs1568889 0.838 rs4614434 chr11:28302234 C/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.77 19.55 0.61 4.51e-67 Bipolar disorder; BRCA cis rs2066819 1.000 rs41392645 chr12:56696742 A/G cg26714650 chr12:56694279 CS -1.18 -15.85 -0.53 5.52e-48 Psoriasis vulgaris; BRCA cis rs832540 1.000 rs192249 chr5:56197514 C/G cg24531977 chr5:56204891 C5orf35 -0.45 -9.27 -0.34 2.72e-19 Coronary artery disease; BRCA trans rs7395662 0.500 rs10838984 chr11:48640485 C/T cg15704280 chr7:45808275 SEPT13 -0.53 -10.61 -0.39 2.56e-24 HDL cholesterol; BRCA cis rs17376456 1.000 rs59472588 chr5:93511981 A/G cg21475434 chr5:93447410 FAM172A 0.63 8.4 0.32 2.94e-16 Diabetic retinopathy; BRCA cis rs7975161 0.640 rs10778323 chr12:104746075 A/G cg25273343 chr12:104657179 TXNRD1 0.48 9.84 0.36 2.24e-21 Toenail selenium levels; BRCA cis rs3820928 0.874 rs1917123 chr2:227889783 T/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.49 -0.32 1.48e-16 Pulmonary function; BRCA trans rs9291683 0.530 rs4235346 chr4:9945296 C/T cg26043149 chr18:55253948 FECH -0.39 -8.88 -0.33 6.72e-18 Bone mineral density; BRCA cis rs7927771 0.832 rs10838698 chr11:47385923 G/A cg20307385 chr11:47447363 PSMC3 0.37 7.92 0.3 1.07e-14 Subjective well-being; BRCA cis rs9814567 0.929 rs2241556 chr3:134183312 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.56 17.56 0.57 1.33e-56 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9291683 0.517 rs11736479 chr4:10017387 G/C cg00071950 chr4:10020882 SLC2A9 0.66 16.76 0.55 1.6e-52 Bone mineral density; BRCA cis rs10504229 0.683 rs7817188 chr8:58129549 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA trans rs2797160 0.935 rs926855 chr6:126021782 A/G cg05039488 chr6:79577232 IRAK1BP1 0.35 7.83 0.3 2.11e-14 Endometrial cancer; BRCA trans rs11098499 0.865 rs28845498 chr4:120405186 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.0 0.3 5.96e-15 Corneal astigmatism; BRCA cis rs9467773 0.620 rs6925087 chr6:26592853 T/A cg11502198 chr6:26597334 ABT1 0.58 12.51 0.44 2.71e-32 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.790 rs6570723 chr6:146151230 A/T cg05347473 chr6:146136440 FBXO30 0.39 8.06 0.3 3.81e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs739401 0.572 rs404629 chr11:3077025 A/G cg08508325 chr11:3079039 CARS -0.46 -16.5 -0.55 3.33e-51 Longevity; BRCA cis rs651907 0.514 rs10936744 chr3:101433440 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.54 14.18 0.49 7.01e-40 Colorectal cancer; BRCA cis rs1008375 0.863 rs4698632 chr4:17614894 T/C cg04450456 chr4:17643702 FAM184B 0.37 10.65 0.39 1.73e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12497850 0.897 rs6781790 chr3:49044767 C/T cg07636037 chr3:49044803 WDR6 0.98 29.58 0.76 8.59e-122 Parkinson's disease; BRCA cis rs12701220 0.655 rs7784403 chr7:1153077 G/A cg16145915 chr7:1198662 ZFAND2A -0.47 -9.37 -0.35 1.25e-19 Bronchopulmonary dysplasia; BRCA cis rs7666738 0.962 rs2865985 chr4:99068009 T/C cg03676636 chr4:99064102 C4orf37 0.23 8.26 0.31 8.09e-16 Colonoscopy-negative controls vs population controls; BRCA trans rs9858542 1.000 rs1131095 chr3:49714225 T/C cg21659725 chr3:3221576 CRBN -0.47 -10.03 -0.37 4.52e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6582630 0.513 rs11181246 chr12:38302670 C/T cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs2882667 0.898 rs6882583 chr5:138385796 C/T cg04439458 chr5:138467593 SIL1 -0.32 -8.83 -0.33 9.64e-18 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs713587 1.000 rs713587 chr2:25158281 C/T cg04586622 chr2:25135609 ADCY3 0.39 9.47 0.35 5.45e-20 Body mass index in non-asthmatics; BRCA cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg05025164 chr4:1340916 KIAA1530 -0.63 -12.74 -0.45 2.61e-33 Obesity-related traits; BRCA cis rs1707322 0.963 rs6690652 chr1:46376692 G/T cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.54e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2836974 0.897 rs11911112 chr21:40528346 A/C cg11644478 chr21:40555479 PSMG1 0.85 19.84 0.62 1.29e-68 Cognitive function; BRCA trans rs7248779 0.532 rs10153475 chr19:2413961 G/C cg25835954 chr13:50160062 RCBTB1 0.45 8.74 0.33 1.97e-17 Cortisol levels (saliva); BRCA cis rs735396 0.770 rs2257764 chr12:121446446 T/A cg02403541 chr12:121454288 C12orf43 -0.64 -12.39 -0.44 9.5e-32 N-glycan levels; BRCA cis rs7011049 1.000 rs11985185 chr8:53834494 T/C cg26025543 chr8:53854495 NA 0.54 9.86 0.36 1.85e-21 Systolic blood pressure; BRCA cis rs9487051 0.872 rs4601178 chr6:109611246 C/T cg12927641 chr6:109611667 NA -0.42 -11.09 -0.4 2.8e-26 Reticulocyte fraction of red cells; BRCA cis rs12612619 0.732 rs11126857 chr2:27297757 G/A cg00617064 chr2:27272375 NA 0.31 8.19 0.31 1.4e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs1005277 0.579 rs2021649 chr10:38392122 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.08 -0.4 3.36e-26 Extrinsic epigenetic age acceleration; BRCA trans rs7824557 0.836 rs2736378 chr8:11119760 G/A cg06636001 chr8:8085503 FLJ10661 -0.56 -10.64 -0.39 1.82e-24 Retinal vascular caliber; BRCA cis rs701145 0.938 rs355778 chr3:154030349 C/T cg17054900 chr3:154042577 DHX36 0.68 11.88 0.43 1.56e-29 Coronary artery disease; BRCA cis rs6598955 0.543 rs60433268 chr1:26548055 A/C cg04990556 chr1:26633338 UBXN11 0.7 12.12 0.43 1.45e-30 Obesity-related traits; BRCA trans rs7200543 1.000 rs1135999 chr16:15131962 A/G cg24683922 chr1:11983373 KIAA2013 -0.39 -8.71 -0.33 2.69e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs9814567 1.000 rs7648990 chr3:134244390 T/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.8 -0.33 1.23e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg09263875 chr16:632152 PIGQ 0.72 21.62 0.65 3.1e-78 Height; BRCA cis rs4363385 0.818 rs6661791 chr1:152994113 G/A cg25856811 chr1:152973957 SPRR3 -0.31 -8.34 -0.31 4.69e-16 Inflammatory skin disease; BRCA cis rs6547741 1.000 rs6737921 chr2:27839107 T/C cg27432699 chr2:27873401 GPN1 0.44 9.29 0.34 2.39e-19 Oral cavity cancer; BRCA cis rs11229555 0.645 rs11229428 chr11:58180382 C/T cg15696309 chr11:58395628 NA -0.45 -9.61 -0.36 1.64e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA trans rs4942242 0.663 rs17460812 chr13:44215504 A/G cg19169023 chr15:41853346 TYRO3 -0.56 -11.42 -0.41 1.3e-27 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg16606324 chr3:10149918 C3orf24 0.5 10.02 0.37 4.84e-22 Alzheimer's disease; BRCA cis rs13064411 0.696 rs9860549 chr3:113148368 G/A cg18753928 chr3:113234510 CCDC52 -0.43 -8.51 -0.32 1.2e-16 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs10771431 0.597 rs10771412 chr12:9354353 A/C cg08997352 chr12:9597637 DDX12 -0.54 -10.21 -0.37 8.78e-23 Breast size; BRCA cis rs8062405 0.754 rs3859172 chr16:28566158 G/T cg16576597 chr16:28551801 NUPR1 0.29 8.15 0.31 1.91e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs12949688 0.967 rs1990231 chr17:55821002 G/C cg12582317 chr17:55822272 NA 0.32 7.93 0.3 9.68e-15 Schizophrenia; BRCA cis rs9527 0.590 rs10883818 chr10:104759586 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.01 0.37 5.03e-22 Arsenic metabolism; BRCA trans rs7746199 0.736 rs13212318 chr6:27688841 A/C cg01620082 chr3:125678407 NA -0.92 -10.33 -0.38 3.07e-23 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg16339924 chr4:17578868 LAP3 0.62 15.4 0.52 1e-45 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12586317 0.547 rs4982236 chr14:35468046 C/G cg16230307 chr14:35515116 FAM177A1 0.73 15.28 0.52 3.85e-45 Psoriasis; BRCA cis rs3858526 0.628 rs1840177 chr11:5944627 T/G cg02574844 chr11:5959923 NA 0.47 10.04 0.37 3.93e-22 DNA methylation (variation); BRCA cis rs9815354 0.812 rs60659106 chr3:41949569 G/C cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs7615952 0.512 rs4646765 chr3:125820707 G/A cg18479299 chr3:125709523 NA -0.54 -8.36 -0.31 4.05e-16 Blood pressure (smoking interaction); BRCA cis rs11190604 1.000 rs10883505 chr10:102280772 C/T cg07080220 chr10:102295463 HIF1AN 0.62 14.55 0.5 1.2e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2576037 0.562 rs477826 chr18:44397649 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.53 -10.96 -0.4 9.57e-26 Personality dimensions; BRCA cis rs2290405 0.527 rs4690332 chr4:910520 C/T cg04824913 chr4:887549 GAK -0.75 -15.54 -0.52 1.94e-46 Systemic sclerosis; BRCA cis rs933688 0.877 rs10474352 chr5:90732225 C/T cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.8 17.07 0.56 4.05e-54 Smoking behavior; BRCA cis rs2075371 1.000 rs2505 chr7:133979552 C/T cg20476274 chr7:133979776 SLC35B4 0.65 19.39 0.61 3.04e-66 Mean platelet volume; BRCA cis rs713587 0.646 rs2384061 chr2:25135620 C/T cg04586622 chr2:25135609 ADCY3 0.44 11.36 0.41 2.32e-27 Body mass index in non-asthmatics; BRCA cis rs10751667 0.643 rs7396046 chr11:937176 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs10911363 0.573 rs2761580 chr1:183516989 A/T cg09173681 chr1:183549694 NCF2 0.53 10.78 0.39 5.31e-25 Systemic lupus erythematosus; BRCA cis rs6121246 0.559 rs6119650 chr20:30258480 C/A cg13852791 chr20:30311386 BCL2L1 0.95 22.81 0.67 1.1e-84 Mean corpuscular hemoglobin; BRCA cis rs710865 0.516 rs12062540 chr1:19529204 A/G cg13387374 chr1:19411106 UBR4 0.39 8.51 0.32 1.28e-16 Brain structure; BRCA cis rs939658 0.683 rs1434459 chr15:79465210 T/C cg17916960 chr15:79447300 NA -0.38 -9.39 -0.35 1.05e-19 Refractive error; BRCA cis rs2559856 0.967 rs7970837 chr12:102081576 A/G cg12213457 chr12:102090980 CHPT1 -0.37 -8.09 -0.3 3.01e-15 Blood protein levels; BRCA cis rs875971 0.792 rs6971752 chr7:65737986 G/A cg11764359 chr7:65958608 NA -0.77 -17.87 -0.58 3.29e-58 Aortic root size; BRCA cis rs826838 1.000 rs11609286 chr12:38875511 A/G cg13010199 chr12:38710504 ALG10B -0.56 -12.19 -0.43 7.11e-31 Heart rate; BRCA cis rs2576037 0.583 rs478820 chr18:44397782 G/A cg19077165 chr18:44547161 KATNAL2 -0.59 -13.29 -0.47 9.5e-36 Personality dimensions; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg21143896 chr7:2802374 GNA12 -0.31 -7.97 -0.3 7.58e-15 Height; BRCA cis rs2795502 0.938 rs3121324 chr10:43379515 C/T cg20628663 chr10:43360327 NA 0.65 13.24 0.46 1.62e-35 Blood protein levels; BRCA cis rs34779708 0.649 rs34421369 chr10:35550275 G/C cg03585969 chr10:35415529 CREM 0.43 8.64 0.32 4.39e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1215050 0.791 rs700738 chr4:98907909 C/A cg05340658 chr4:99064831 C4orf37 -0.42 -9.03 -0.34 1.98e-18 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9443645 0.527 rs1413969 chr6:79790982 A/G cg18132916 chr6:79620363 NA -0.4 -8.42 -0.32 2.47e-16 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs34215106 chr3:52659124 T/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.53 -0.44 2.28e-32 Bipolar disorder; BRCA cis rs2842992 0.872 rs2758328 chr6:160090731 T/A cg11366901 chr6:160182831 ACAT2 0.78 14.98 0.51 1.12e-43 Age-related macular degeneration (geographic atrophy); BRCA cis rs7312933 0.558 rs11181483 chr12:42798384 G/C cg01256987 chr12:42539512 GXYLT1 -0.42 -8.01 -0.3 5.64e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs921968 0.541 rs642520 chr2:219423605 A/G cg02176678 chr2:219576539 TTLL4 -0.46 -12.03 -0.43 3.46e-30 Mean corpuscular hemoglobin concentration; BRCA trans rs7618501 0.633 rs2856234 chr3:50139142 A/G cg21659725 chr3:3221576 CRBN -0.47 -11.85 -0.42 2e-29 Intelligence (multi-trait analysis); BRCA cis rs2073300 1.000 rs6137966 chr20:23444359 A/T cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2019216 0.542 rs8073228 chr17:21909838 C/G cg22648282 chr17:21454238 C17orf51 -0.42 -9.79 -0.36 3.49e-21 Pelvic organ prolapse; BRCA trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg15556689 chr8:8085844 FLJ10661 -0.35 -9.56 -0.35 2.4e-20 Neuroticism; BRCA cis rs875971 0.545 rs73152714 chr7:65999628 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.51 9.7 0.36 7.89e-21 Aortic root size; BRCA cis rs7811142 1.000 rs112317829 chr7:100043173 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 25.53 0.71 1.19e-99 Platelet count; BRCA trans rs10028773 0.506 rs12374346 chr4:120281705 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Educational attainment; BRCA cis rs6087990 0.865 rs6058859 chr20:31335157 A/G cg13636640 chr20:31349939 DNMT3B 0.7 20.34 0.63 2.73e-71 Ulcerative colitis; BRCA cis rs12477438 0.765 rs56167745 chr2:99600478 T/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.57 -12.72 -0.45 3.39e-33 Chronic sinus infection; BRCA cis rs2576037 0.583 rs10070 chr18:44388899 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.64 -0.39 1.9e-24 Personality dimensions; BRCA cis rs79839061 0.610 rs11731387 chr4:851357 C/T cg14530993 chr4:882597 GAK 0.53 9.31 0.35 2.05e-19 Intelligence (multi-trait analysis); BRCA cis rs36051895 0.664 rs3780377 chr9:5110899 T/C cg02405213 chr9:5042618 JAK2 -0.49 -8.78 -0.33 1.55e-17 Pediatric autoimmune diseases; BRCA cis rs7584330 0.666 rs72620817 chr2:238353661 C/T cg14458575 chr2:238380390 NA 0.72 15.59 0.52 1.16e-46 Prostate cancer; BRCA trans rs61931739 0.500 rs11052990 chr12:34058647 T/A cg13010199 chr12:38710504 ALG10B 0.5 9.57 0.35 2.29e-20 Morning vs. evening chronotype; BRCA cis rs10871290 1.000 rs10871290 chr16:74472696 C/T cg01733217 chr16:74700730 RFWD3 -0.49 -11.72 -0.42 7.33e-29 Breast cancer; BRCA cis rs12142240 0.698 rs67200518 chr1:46835777 T/C cg14993813 chr1:46806288 NSUN4 -0.49 -9.44 -0.35 7.1e-20 Menopause (age at onset); BRCA cis rs4862307 0.514 rs7696176 chr4:185014390 A/G cg06737308 chr4:185021514 ENPP6 0.51 12.48 0.44 4.02e-32 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs7552404 0.889 rs380075 chr1:76106961 T/A cg22875332 chr1:76189707 ACADM -0.69 -15.05 -0.51 4.97e-44 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs561341 1.000 rs72823787 chr17:30283809 A/T cg23018236 chr17:30244563 NA -0.68 -10.6 -0.39 2.7e-24 Hip circumference adjusted for BMI; BRCA cis rs9487051 0.837 rs6568561 chr6:109592909 A/G cg21918786 chr6:109611834 NA -0.46 -13.03 -0.46 1.37e-34 Reticulocyte fraction of red cells; BRCA cis rs7818345 0.904 rs11780388 chr8:19271554 A/G cg11303988 chr8:19266685 CSGALNACT1 0.31 8.12 0.31 2.45e-15 Language performance in older adults (adjusted for episodic memory); BRCA cis rs9462027 0.506 rs6934662 chr6:34759884 G/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.97 -0.3 7.34e-15 Systemic lupus erythematosus; BRCA cis rs35110281 0.626 rs162388 chr21:44936032 G/A cg04455712 chr21:45112962 RRP1B 0.36 9.43 0.35 7.57e-20 Mean corpuscular volume; BRCA cis rs11599315 0.507 rs12217329 chr10:1341897 A/G cg27336068 chr10:1336103 ADARB2 -0.29 -7.99 -0.3 6.44e-15 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs12586317 0.620 rs79832710 chr14:35547434 G/T cg16230307 chr14:35515116 FAM177A1 0.75 15.03 0.51 5.98e-44 Psoriasis; BRCA cis rs4665809 0.556 rs10221814 chr2:26442759 C/T cg26119090 chr2:26468346 HADHA;HADHB -1.01 -22.16 -0.66 3.76e-81 Gut microbiome composition (summer); BRCA cis rs6952808 0.964 rs6945719 chr7:1932688 G/A cg04267008 chr7:1944627 MAD1L1 -0.67 -14.92 -0.51 2.09e-43 Bipolar disorder and schizophrenia; BRCA cis rs6545883 0.868 rs778755 chr2:61781037 A/G cg15711740 chr2:61764176 XPO1 0.48 11.8 0.42 3.15e-29 Tuberculosis; BRCA cis rs6815814 0.950 rs66819621 chr4:38819403 A/G cg02016764 chr4:38805732 TLR1 -0.57 -8.32 -0.31 5.23e-16 Breast cancer; BRCA trans rs72766638 0.895 rs55924785 chr9:136929586 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.68 -9.9 -0.36 1.39e-21 Mosquito bite size; BRCA cis rs8028182 0.636 rs7171507 chr15:75737287 T/C cg20655648 chr15:75932815 IMP3 0.41 8.03 0.3 4.8e-15 Sudden cardiac arrest; BRCA trans rs208520 0.526 rs1385219 chr6:66754476 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.01 29.36 0.76 1.31e-120 Exhaled nitric oxide output; BRCA cis rs7246657 0.722 rs2291002 chr19:38033926 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.17 0.34 6.65e-19 Coronary artery calcification; BRCA trans rs8073060 0.586 rs6505485 chr17:33996102 C/T cg19694781 chr19:47549865 TMEM160 -0.99 -18.78 -0.6 5.3e-63 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs4906332 1.000 rs78316803 chr14:103942863 A/G cg26031613 chr14:104095156 KLC1 -0.44 -8.0 -0.3 6.01e-15 Coronary artery disease; BRCA cis rs3820928 1.000 rs7561378 chr2:227772248 T/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.41 -0.32 2.72e-16 Pulmonary function; BRCA cis rs8180040 0.654 rs6791062 chr3:47174343 T/A cg27129171 chr3:47204927 SETD2 0.73 17.83 0.58 5.34e-58 Colorectal cancer; BRCA cis rs9420 0.961 rs11570190 chr11:57560452 A/C cg19752551 chr11:57585705 CTNND1 -0.5 -12.27 -0.44 3.21e-31 Schizophrenia; BRCA cis rs965469 0.947 rs6037529 chr20:3261006 C/T cg25506879 chr20:3388711 C20orf194 -0.51 -10.15 -0.37 1.57e-22 IFN-related cytopenia; BRCA cis rs12950390 0.853 rs11655112 chr17:45856563 T/C cg06532163 chr17:45867833 NA 0.38 7.91 0.3 1.17e-14 IgG glycosylation; BRCA trans rs61931739 0.591 rs1608907 chr12:33945435 A/G cg26384229 chr12:38710491 ALG10B 0.39 8.87 0.33 7.17e-18 Morning vs. evening chronotype; BRCA cis rs17711722 0.727 rs2658585 chr7:65461941 A/T cg11764359 chr7:65958608 NA 0.62 13.51 0.47 8.69e-37 Calcium levels; BRCA cis rs7666738 0.830 rs13115356 chr4:98933171 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1953600 0.837 rs2573352 chr10:81939813 T/C cg04850286 chr10:81895943 PLAC9 0.32 9.05 0.34 1.75e-18 Sarcoidosis; BRCA cis rs12477438 0.520 rs4402818 chr2:99717608 A/G cg08885076 chr2:99613938 TSGA10 0.47 10.93 0.4 1.31e-25 Chronic sinus infection; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg23358479 chr7:1110784 C7orf50 -0.47 -7.9 -0.3 1.26e-14 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs28374715 0.662 rs8038983 chr15:41473316 G/A cg18705301 chr15:41695430 NDUFAF1 -0.87 -18.05 -0.58 3.56e-59 Ulcerative colitis; BRCA cis rs57677839 1 rs57677839 chr11:17028189 G/A cg15378786 chr11:17036137 PLEKHA7 0.89 25.61 0.71 4.72e-100 Coronary artery disease; BRCA cis rs7267979 0.966 rs2500433 chr20:25296335 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.58 -0.32 7.04e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2180341 1.000 rs13218061 chr6:127653758 G/A cg24812749 chr6:127587940 RNF146 0.88 20.66 0.63 4.91e-73 Breast cancer; BRCA cis rs270601 0.770 rs1007602 chr5:131602166 T/C cg07262247 chr5:131593730 PDLIM4 0.36 8.58 0.32 7.25e-17 Acylcarnitine levels; BRCA trans rs11098499 0.866 rs9995136 chr4:120286845 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs10267417 0.603 rs10266969 chr7:19903452 G/A cg07541023 chr7:19748670 TWISTNB 0.45 8.23 0.31 1.09e-15 Night sleep phenotypes; BRCA cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg08999081 chr20:33150536 PIGU 0.45 12.54 0.44 2.02e-32 Glomerular filtration rate (creatinine); BRCA cis rs8072100 0.846 rs7214799 chr17:45702099 C/T cg08085267 chr17:45401833 C17orf57 0.61 12.51 0.44 2.72e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7945705 0.837 rs2742474 chr11:9002089 A/G cg12365402 chr11:9010492 NRIP3 -0.42 -9.91 -0.37 1.22e-21 Hemoglobin concentration; BRCA cis rs11608355 0.545 rs6606723 chr12:109905044 C/G cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs7011049 1.000 rs11997774 chr8:53833370 T/A cg26025543 chr8:53854495 NA 0.55 9.94 0.37 9.57e-22 Systolic blood pressure; BRCA cis rs2991971 0.747 rs2492841 chr1:45894891 G/T cg15605315 chr1:45957053 TESK2 -0.42 -8.47 -0.32 1.66e-16 High light scatter reticulocyte count; BRCA cis rs17253792 0.822 rs10147688 chr14:56054642 T/C cg24579896 chr14:56047964 C14orf33;KTN1 0.57 7.98 0.3 6.98e-15 Putamen volume; BRCA cis rs9381040 0.655 rs2268187 chr6:41042993 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.39 -9.25 -0.34 3.34e-19 Alzheimer's disease (late onset); BRCA cis rs55882075 0.967 rs62404346 chr5:179141391 A/C cg14593053 chr5:179126677 CANX 0.38 9.43 0.35 7.55e-20 Monocyte percentage of white cells; BRCA cis rs738321 0.671 rs3761446 chr22:38595483 G/A cg25457927 chr22:38595422 NA -0.41 -13.87 -0.48 1.99e-38 Breast cancer; BRCA cis rs12579753 0.827 rs7311917 chr12:82187551 G/T cg07988820 chr12:82153109 PPFIA2 -0.51 -8.89 -0.33 6.18e-18 Resting heart rate; BRCA trans rs61931739 0.500 rs12829125 chr12:34314789 A/G cg13010199 chr12:38710504 ALG10B 0.48 9.45 0.35 6.55e-20 Morning vs. evening chronotype; BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg16145915 chr7:1198662 ZFAND2A -0.46 -11.45 -0.41 9.87e-28 Longevity;Endometriosis; BRCA cis rs4332037 0.664 rs73046334 chr7:1887037 T/C cg12591125 chr7:1885375 MAD1L1 0.51 8.99 0.34 2.82e-18 Bipolar disorder; BRCA cis rs2280018 1.000 rs2280018 chr16:15150833 A/C cg07549590 chr16:15018862 NA -0.35 -8.61 -0.32 5.77e-17 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA trans rs11722228 0.508 rs3822246 chr4:10094698 G/A cg26043149 chr18:55253948 FECH 1.08 23.16 0.68 1.29e-86 Gout;Urate levels;Serum uric acid levels; BRCA cis rs4970988 0.556 rs2280078 chr1:150600181 C/T cg17724175 chr1:150552817 MCL1 -0.29 -9.99 -0.37 6.33e-22 Urate levels; BRCA cis rs2625529 0.730 rs2929528 chr15:72269337 C/A cg16672083 chr15:72433130 SENP8 0.73 17.34 0.57 1.65e-55 Red blood cell count; BRCA trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg15556689 chr8:8085844 FLJ10661 -0.34 -9.03 -0.34 1.95e-18 Neuroticism; BRCA cis rs290268 0.845 rs290266 chr9:93537952 T/A cg02608019 chr9:93564028 SYK 0.48 9.94 0.37 9.45e-22 Platelet count; BRCA cis rs72928364 1.000 rs17398684 chr3:100695342 G/A cg10123952 chr3:100791384 NA 0.53 7.85 0.3 1.71e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs72781680 0.716 rs2675363 chr2:24080003 G/C cg08917208 chr2:24149416 ATAD2B 0.59 10.15 0.37 1.51e-22 Lymphocyte counts; BRCA cis rs4819052 0.851 rs2838858 chr21:46681093 T/A cg11663144 chr21:46675770 NA -0.58 -13.7 -0.48 1.26e-37 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs6088580 0.634 rs6059880 chr20:33088669 G/A cg08999081 chr20:33150536 PIGU 0.46 12.85 0.45 8.9e-34 Glomerular filtration rate (creatinine); BRCA cis rs2652834 0.851 rs4468558 chr15:63346681 T/C cg05507819 chr15:63340323 TPM1 0.53 9.5 0.35 4.01e-20 HDL cholesterol; BRCA cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg18404041 chr3:52824283 ITIH1 -0.42 -12.26 -0.44 3.51e-31 Bipolar disorder; BRCA cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg11663144 chr21:46675770 NA -0.6 -13.87 -0.48 2.05e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs11190604 1.000 rs10883507 chr10:102291275 C/T cg07080220 chr10:102295463 HIF1AN 0.63 14.78 0.5 9.71e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs9318086 0.712 rs9318100 chr13:24442482 A/G cg25267304 chr13:24462978 PCOTH;MIPEP -0.29 -8.33 -0.31 4.93e-16 Myopia (pathological); BRCA cis rs637571 0.522 rs550435 chr11:65732651 G/A cg02427764 chr11:65769310 BANF1;EIF1AD 0.6 13.65 0.48 2.05e-37 Eosinophil percentage of white cells; BRCA cis rs7772486 0.875 rs1125461 chr6:146417653 C/T cg23711669 chr6:146136114 FBXO30 0.76 17.27 0.56 3.82e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs6484504 0.512 rs7940020 chr11:31366453 T/G cg26647111 chr11:31128758 NA 0.45 9.64 0.36 1.25e-20 Red blood cell count; BRCA cis rs7615952 0.641 rs12488180 chr3:125782236 C/T cg05084668 chr3:125655381 ALG1L -0.47 -8.16 -0.31 1.84e-15 Blood pressure (smoking interaction); BRCA trans rs2204008 0.775 rs12369238 chr12:38176051 A/G cg06521331 chr12:34319734 NA -0.53 -10.08 -0.37 2.83e-22 Bladder cancer; BRCA cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg06636001 chr8:8085503 FLJ10661 0.58 13.76 0.48 6.14e-38 Mood instability; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg15383120 chr6:291909 DUSP22 0.53 11.3 0.41 4.09e-27 Menopause (age at onset); BRCA cis rs1595825 0.945 rs76877032 chr2:198840000 G/A cg19156104 chr2:198669113 PLCL1 -0.44 -8.27 -0.31 7.89e-16 Ulcerative colitis; BRCA cis rs10504229 1.000 rs17816781 chr8:58186161 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.75 -0.36 5.08e-21 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs1475389 chr1:46816429 T/C cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs4594175 0.926 rs11157800 chr14:51615502 A/T cg23942311 chr14:51606299 NA 0.32 8.11 0.31 2.53e-15 Cancer; BRCA cis rs3768617 0.510 rs10752903 chr1:183100863 A/G ch.1.3577855R chr1:183094577 LAMC1 0.67 17.68 0.57 3.2e-57 Fuchs's corneal dystrophy; BRCA cis rs7208859 0.573 rs216443 chr17:28931871 A/G cg13385521 chr17:29058706 SUZ12P 0.76 10.09 0.37 2.66e-22 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.6 -11.43 -0.41 1.14e-27 Alzheimer's disease; BRCA cis rs9467773 0.595 rs2451736 chr6:26620544 G/A cg09904177 chr6:26538194 HMGN4 0.47 14.72 0.5 1.82e-42 Intelligence (multi-trait analysis); BRCA cis rs873946 0.648 rs12782123 chr10:134554662 G/A cg18305652 chr10:134549665 INPP5A 0.5 11.47 0.41 8.02e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7592578 0.771 rs12053190 chr2:191383348 A/G cg11845111 chr2:191398756 TMEM194B -0.77 -14.87 -0.51 3.74e-43 Diastolic blood pressure; BRCA cis rs72781680 0.898 rs72798064 chr2:23982832 T/C cg20701182 chr2:24300061 SF3B14 0.56 8.67 0.32 3.58e-17 Lymphocyte counts; BRCA cis rs12760731 0.565 rs12027723 chr1:178090271 A/T cg00404053 chr1:178313656 RASAL2 0.67 8.02 0.3 5.06e-15 Obesity-related traits; BRCA cis rs9381040 0.655 rs879491 chr6:41026953 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.39 -8.96 -0.33 3.42e-18 Alzheimer's disease (late onset); BRCA cis rs4285028 0.747 rs9852845 chr3:121390618 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.88 -0.48 1.71e-38 Multiple sclerosis; BRCA trans rs11098499 0.743 rs11098501 chr4:120252017 T/G cg25214090 chr10:38739885 LOC399744 0.45 10.38 0.38 2.04e-23 Corneal astigmatism; BRCA trans rs3857536 0.605 rs36040831 chr6:66876588 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.66 -15.01 -0.51 8e-44 Blood trace element (Cu levels); BRCA cis rs778371 0.723 rs34707169 chr2:233699459 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -17.0 -0.56 9.22e-54 Schizophrenia; BRCA cis rs6088590 1.000 rs11698977 chr20:33449691 C/T cg24642439 chr20:33292090 TP53INP2 0.69 15.45 0.52 5.47e-46 Coronary artery disease; BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg08219700 chr8:58056026 NA 0.59 9.83 0.36 2.59e-21 Developmental language disorder (linguistic errors); BRCA cis rs6429082 0.806 rs2382570 chr1:235570523 G/A cg26050004 chr1:235667680 B3GALNT2 -0.34 -8.13 -0.31 2.27e-15 Adiposity; BRCA cis rs524281 0.861 rs2177053 chr11:65966145 A/C cg16950941 chr11:66035639 RAB1B -0.38 -8.11 -0.31 2.68e-15 Electroencephalogram traits; BRCA cis rs10046574 0.519 rs11505985 chr7:135210197 G/T cg27474649 chr7:135195673 CNOT4 0.64 10.75 0.39 6.98e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9393692 0.875 rs2142703 chr6:26289605 A/G cg05868516 chr6:26286170 HIST1H4H 0.5 11.28 0.41 4.88e-27 Educational attainment; BRCA cis rs11123170 0.543 rs4849180 chr2:113985186 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.66 10.78 0.39 5.15e-25 Renal function-related traits (BUN); BRCA cis rs847577 0.722 rs7790736 chr7:97713039 G/A cg24562669 chr7:97807699 LMTK2 0.61 18.04 0.58 4.12e-59 Breast cancer; BRCA cis rs7959452 0.590 rs56054057 chr12:69775972 C/T cg20891283 chr12:69753455 YEATS4 0.73 22.1 0.66 7.57e-81 Blood protein levels; BRCA cis rs4975709 0.589 rs931508 chr5:1861224 C/G cg11168104 chr5:1857477 NA -0.35 -9.29 -0.34 2.44e-19 Cardiovascular disease risk factors; BRCA cis rs2836974 0.829 rs8128191 chr21:40527311 A/G cg11890956 chr21:40555474 PSMG1 1.06 31.86 0.78 4.18e-134 Cognitive function; BRCA cis rs9527 0.590 rs2274339 chr10:104860053 T/A cg04362960 chr10:104952993 NT5C2 0.46 10.35 0.38 2.54e-23 Arsenic metabolism; BRCA cis rs586533 0.881 rs637006 chr11:99495383 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs9287719 0.967 rs3815521 chr2:10743654 G/C cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs2204008 0.805 rs4882575 chr12:37940573 G/A cg26384229 chr12:38710491 ALG10B -0.58 -13.44 -0.47 1.99e-36 Bladder cancer; BRCA cis rs10504229 0.906 rs56138544 chr8:58184558 A/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs9487051 0.768 rs437779 chr6:109527691 T/G cg01475377 chr6:109611718 NA -0.42 -10.48 -0.38 7.98e-24 Reticulocyte fraction of red cells; BRCA cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg02187348 chr16:89574699 SPG7 -0.48 -11.77 -0.42 4.44e-29 Multiple myeloma (IgH translocation); BRCA cis rs72781680 0.561 rs72783615 chr2:24296397 C/A cg08917208 chr2:24149416 ATAD2B 0.56 8.64 0.32 4.37e-17 Lymphocyte counts; BRCA cis rs896854 0.654 rs28591375 chr8:95973637 C/G cg13393036 chr8:95962371 TP53INP1 -0.3 -8.05 -0.3 3.96e-15 Type 2 diabetes; BRCA cis rs6964587 1.000 rs6950470 chr7:91680641 G/A cg17063962 chr7:91808500 NA 0.58 13.72 0.48 9.56e-38 Breast cancer; BRCA cis rs12142240 0.738 rs41293275 chr1:46806429 A/T cg10495392 chr1:46806563 NSUN4 0.46 8.46 0.32 1.82e-16 Menopause (age at onset); BRCA cis rs2153535 0.580 rs915350 chr6:8443486 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.35 0.49 1.13e-40 Motion sickness; BRCA cis rs651907 0.535 rs11717638 chr3:101505468 A/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.35 -0.31 4.34e-16 Colorectal cancer; BRCA cis rs826838 0.806 rs826873 chr12:39121305 G/A cg26384229 chr12:38710491 ALG10B -0.61 -15.85 -0.53 5.83e-48 Heart rate; BRCA cis rs172166 0.694 rs188105 chr6:28071393 C/T cg02631126 chr6:28058918 ZSCAN12L1 0.25 7.91 0.3 1.16e-14 Cardiac Troponin-T levels; BRCA cis rs478304 0.817 rs524475 chr11:65518065 T/A cg08755490 chr11:65554678 OVOL1 0.52 10.88 0.4 2.11e-25 Acne (severe); BRCA cis rs3125734 0.608 rs7094950 chr10:64019744 T/C cg19640130 chr10:64028056 RTKN2 -0.31 -8.91 -0.33 5.23e-18 Rheumatoid arthritis; BRCA cis rs634534 0.622 rs531612 chr11:65705432 C/T cg02427764 chr11:65769310 BANF1;EIF1AD -0.43 -9.06 -0.34 1.62e-18 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs7833986 0.501 rs72653990 chr8:57037115 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.71 13.06 0.46 9.86e-35 Height; BRCA trans rs61931739 0.517 rs1586409 chr12:34046614 C/A cg13010199 chr12:38710504 ALG10B 0.4 8.16 0.31 1.74e-15 Morning vs. evening chronotype; BRCA trans rs1997103 1.000 rs1965556 chr7:55403584 C/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs9473147 0.516 rs10948367 chr6:47585615 A/G cg12968598 chr6:47444699 CD2AP 0.43 9.29 0.35 2.29e-19 Platelet distribution width;Mean platelet volume; BRCA cis rs72781680 0.664 rs2712076 chr2:23993366 T/C cg08917208 chr2:24149416 ATAD2B 0.65 10.42 0.38 1.42e-23 Lymphocyte counts; BRCA cis rs7666738 0.830 rs10049627 chr4:99025272 A/C cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.57 -11.85 -0.42 1.95e-29 Lymphocyte counts; BRCA cis rs35146811 0.807 rs6465761 chr7:99620277 G/C cg13334819 chr7:99746414 C7orf59 -0.4 -9.56 -0.35 2.46e-20 Coronary artery disease; BRCA cis rs3862030 0.720 rs3740414 chr10:104232809 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.18e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs4819052 0.851 rs28501512 chr21:46676702 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.47 8.78 0.33 1.53e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1552244 1.000 rs68045038 chr3:10151828 A/G cg16606324 chr3:10149918 C3orf24 0.56 11.14 0.4 1.82e-26 Alzheimer's disease; BRCA cis rs2882667 0.654 rs825760 chr5:138139974 G/T cg04439458 chr5:138467593 SIL1 0.35 8.4 0.32 2.98e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2075371 1.000 rs2598291 chr7:133988313 C/G cg02659138 chr7:134003124 SLC35B4 0.33 10.32 0.38 3.35e-23 Mean platelet volume; BRCA cis rs34172651 0.517 rs200528 chr16:24759131 A/G cg04756594 chr16:24857601 SLC5A11 -0.55 -12.43 -0.44 6.24e-32 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.569 rs7735009 chr5:93260865 T/C cg25358565 chr5:93447407 FAM172A -0.52 -9.57 -0.35 2.29e-20 Diabetic retinopathy; BRCA cis rs801193 0.591 rs721717 chr7:66130292 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.84 -0.3 1.85e-14 Aortic root size; BRCA cis rs769267 0.930 rs1865034 chr19:19605763 C/T cg03709012 chr19:19516395 GATAD2A 0.81 18.85 0.6 2.32e-63 Tonsillectomy; BRCA cis rs4862750 0.914 rs6553028 chr4:187876046 T/C cg10295955 chr4:187884368 NA -0.96 -27.8 -0.74 4.23e-112 Lobe attachment (rater-scored or self-reported); BRCA cis rs4819052 0.851 rs2838855 chr21:46680566 C/G cg19498844 chr21:46707878 POFUT2;LOC642852 -0.6 -13.2 -0.46 2.49e-35 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2656056 1 rs2656056 chr15:78722519 T/C cg24631222 chr15:78858424 CHRNA5 -0.49 -9.62 -0.36 1.52e-20 Post bronchodilator FEV1/FVC ratio;Post bronchodilator FEV1; BRCA cis rs2153535 0.580 rs2327051 chr6:8441150 A/G cg07606381 chr6:8435919 SLC35B3 -0.65 -14.25 -0.49 3.18e-40 Motion sickness; BRCA cis rs3824867 0.920 rs4752836 chr11:47465095 T/C cg20307385 chr11:47447363 PSMC3 0.51 11.52 0.41 4.99e-28 Mean corpuscular hemoglobin; BRCA cis rs2836974 0.931 rs8132285 chr21:40655752 T/C cg11890956 chr21:40555474 PSMG1 1.04 29.41 0.76 7.29e-121 Cognitive function; BRCA cis rs7618501 0.633 rs35065728 chr3:50009176 T/C cg24110177 chr3:50126178 RBM5 -0.41 -11.17 -0.4 1.39e-26 Intelligence (multi-trait analysis); BRCA cis rs703842 0.575 rs701006 chr12:58106836 C/T cg04478727 chr12:58166393 METTL1;FAM119B 0.39 8.22 0.31 1.14e-15 Multiple sclerosis; BRCA cis rs8062405 0.965 rs7359397 chr16:28885659 C/T cg09754948 chr16:28834200 ATXN2L 0.46 8.45 0.32 2.02e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7772486 0.686 rs9386131 chr6:146121608 G/A cg23711669 chr6:146136114 FBXO30 0.71 17.09 0.56 3.21e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs10504225 chr8:58145121 A/T cg24829409 chr8:58192753 C8orf71 -0.45 -8.73 -0.33 2.17e-17 Developmental language disorder (linguistic errors); BRCA cis rs6740322 0.901 rs2163228 chr2:43549246 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.68 -11.37 -0.41 2.09e-27 Coronary artery disease; BRCA cis rs6910061 1.000 rs28860023 chr6:11106765 G/A cg27233058 chr6:11094804 LOC221710 0.53 9.35 0.35 1.45e-19 Diabetic kidney disease; BRCA cis rs7772486 0.754 rs9373476 chr6:146139741 C/G cg23711669 chr6:146136114 FBXO30 0.79 19.28 0.61 1.26e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs66887589 0.777 rs10015883 chr4:120268146 A/G cg09307838 chr4:120376055 NA 0.44 9.48 0.35 4.77e-20 Diastolic blood pressure; BRCA trans rs1005277 0.579 rs9418322 chr10:38377296 G/T cg23533926 chr12:111358616 MYL2 -0.41 -8.49 -0.32 1.4e-16 Extrinsic epigenetic age acceleration; BRCA cis rs1865760 0.964 rs6932113 chr6:25913098 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 11.18 0.4 1.23e-26 Height; BRCA cis rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05901451 chr6:126070800 HEY2 0.4 9.69 0.36 8.1e-21 Endometrial cancer; BRCA trans rs6479891 1.000 rs10437345 chr10:65202946 C/T cg14819942 chr15:35414228 NA -0.3 -7.9 -0.3 1.25e-14 Arthritis (juvenile idiopathic); BRCA cis rs875971 0.964 rs11765965 chr7:65842221 A/G cg11764359 chr7:65958608 NA 0.8 19.53 0.61 6.05e-67 Aortic root size; BRCA trans rs4718428 0.705 rs13220977 chr7:66337648 A/T cg18876405 chr7:65276391 NA -0.39 -7.82 -0.3 2.22e-14 Corneal structure; BRCA cis rs2204008 0.775 rs2387809 chr12:38363338 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.46 0.38 9.29e-24 Bladder cancer; BRCA cis rs11608355 0.545 rs11613023 chr12:109898047 T/C cg05360138 chr12:110035743 NA 0.71 13.11 0.46 6.34e-35 Neuroticism; BRCA cis rs780096 0.546 rs1528533 chr2:27595756 G/C cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.42 -0.35 8.38e-20 Total body bone mineral density; BRCA cis rs13392177 0.647 rs6718220 chr2:219066518 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.13 -0.31 2.3e-15 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs561341 0.941 rs17780080 chr17:30343146 G/A cg12193833 chr17:30244370 NA -0.57 -8.43 -0.32 2.29e-16 Hip circumference adjusted for BMI; BRCA cis rs4478137 1.000 rs4478137 chr4:164238385 G/A cg06758707 chr4:164254230 NPY1R 0.59 12.7 0.45 4.19e-33 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs6138458 1.000 rs6114980 chr20:24974288 A/G cg06937882 chr20:24974362 C20orf3 -0.48 -9.46 -0.35 5.84e-20 Blood protein levels; BRCA cis rs13046373 0.535 rs7281489 chr21:31978125 C/T cg27071517 chr21:31768726 KRTAP13-1 0.29 7.95 0.3 8.62e-15 HDL cholesterol; BRCA cis rs61931739 0.500 rs9669027 chr12:34583528 C/T cg06521331 chr12:34319734 NA 0.53 10.32 0.38 3.44e-23 Morning vs. evening chronotype; BRCA cis rs12701220 0.655 rs12702117 chr7:1148702 T/C cg00990874 chr7:1149470 C7orf50 -0.63 -13.33 -0.47 6.13e-36 Bronchopulmonary dysplasia; BRCA cis rs1577917 0.876 rs12212808 chr6:86533972 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.54 -0.42 4.21e-28 Response to antipsychotic treatment; BRCA cis rs701145 0.537 rs2695845 chr3:153881836 G/A cg17054900 chr3:154042577 DHX36 0.56 9.42 0.35 7.83e-20 Coronary artery disease; BRCA cis rs1371614 0.588 rs11126784 chr2:27169842 C/A cg00617064 chr2:27272375 NA -0.31 -8.24 -0.31 1.01e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs875971 0.862 rs9791713 chr7:66105198 C/A cg11764359 chr7:65958608 NA -0.7 -15.03 -0.51 5.83e-44 Aortic root size; BRCA cis rs4563143 0.663 rs2218396 chr19:29236392 C/T cg12756686 chr19:29218302 NA 0.55 11.43 0.41 1.2e-27 Methadone dose in opioid dependence; BRCA trans rs6479891 0.841 rs7085869 chr10:65070163 C/T cg14819942 chr15:35414228 NA -0.34 -8.43 -0.32 2.36e-16 Arthritis (juvenile idiopathic); BRCA cis rs7666738 0.830 rs13328005 chr4:99055480 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.21e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6088590 0.965 rs6088620 chr20:33412022 A/G cg06115741 chr20:33292138 TP53INP2 0.5 11.22 0.41 8.66e-27 Coronary artery disease; BRCA cis rs9649213 0.593 rs6970801 chr7:97925240 T/C cg21770322 chr7:97807741 LMTK2 0.42 11.28 0.41 4.79e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs7927592 0.913 rs11228287 chr11:68349754 A/G cg20283391 chr11:68216788 NA -0.46 -9.04 -0.34 1.89e-18 Total body bone mineral density; BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg12311346 chr5:56204834 C5orf35 -0.79 -15.59 -0.53 1.08e-46 Initial pursuit acceleration; BRCA cis rs600806 0.850 rs4970752 chr1:109930852 C/T cg20591472 chr1:110008990 SYPL2 0.33 8.17 0.31 1.65e-15 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.519 rs8189623 chr12:38351436 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.32 0.57 2.11e-55 Drug-induced liver injury (flucloxacillin); BRCA trans rs11098499 0.866 rs13105020 chr4:120285688 G/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs2576037 0.526 rs4890703 chr18:44522037 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 9.93 0.37 1.06e-21 Personality dimensions; BRCA cis rs9814567 1.000 rs9989967 chr3:134238964 A/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.52 -0.61 6.85e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.85 -14.27 -0.49 2.7e-40 Platelet count; BRCA cis rs2115630 1.000 rs7183401 chr15:85371944 G/T cg12863693 chr15:85201151 NMB -0.34 -8.33 -0.31 5.03e-16 P wave terminal force; BRCA cis rs4906332 1.000 rs78316803 chr14:103942863 A/G cg19000871 chr14:103996768 TRMT61A -0.35 -8.04 -0.3 4.21e-15 Coronary artery disease; BRCA cis rs873946 0.529 rs12258248 chr10:134573767 A/G cg27286337 chr10:134555280 INPP5A 0.63 11.3 0.41 4.09e-27 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs26868 0.766 rs30995 chr16:2248017 C/T cg02248941 chr16:2239361 CASKIN1 -0.44 -11.06 -0.4 3.88e-26 Height; BRCA trans rs11098499 0.863 rs12498539 chr4:120468370 C/T cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs9462027 0.628 rs7741437 chr6:34737553 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -8.01 -0.3 5.4e-15 Systemic lupus erythematosus; BRCA cis rs7568458 0.709 rs2043675 chr2:85769975 C/T cg02493740 chr2:85810744 VAMP5 0.55 11.3 0.41 3.92e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA trans rs1814175 0.527 rs3974435 chr11:49619533 G/A cg03929089 chr4:120376271 NA -0.71 -13.99 -0.48 5.59e-39 Height; BRCA cis rs61931739 0.500 rs11053249 chr12:34518834 A/T cg06521331 chr12:34319734 NA -0.55 -10.01 -0.37 4.99e-22 Morning vs. evening chronotype; BRCA cis rs9443645 0.810 rs10943613 chr6:79745107 C/T cg09184832 chr6:79620586 NA -0.51 -11.2 -0.41 9.93e-27 Intelligence (multi-trait analysis); BRCA trans rs800082 0.690 rs6440260 chr3:144289214 C/A cg24215973 chr2:240111563 HDAC4 -0.42 -10.13 -0.37 1.77e-22 Smoking behavior; BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg13047869 chr3:10149882 C3orf24 0.53 11.01 0.4 5.91e-26 Alzheimer's disease; BRCA cis rs6762 0.748 rs5030780 chr11:838110 C/T cg02261765 chr11:831170 EFCAB4A -0.41 -8.92 -0.33 4.8e-18 Mean platelet volume; BRCA cis rs2115630 1.000 rs2115630 chr15:85364516 C/T cg12863693 chr15:85201151 NMB -0.37 -8.84 -0.33 8.93e-18 P wave terminal force; BRCA cis rs1707322 0.717 rs3014246 chr1:46086077 C/T cg03146154 chr1:46216737 IPP -0.5 -11.13 -0.4 1.98e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2243480 1.000 rs7794661 chr7:65389730 T/C cg18252515 chr7:66147081 NA -0.84 -12.15 -0.43 1.0500000000000001e-30 Diabetic kidney disease; BRCA cis rs4363385 0.747 rs1415960 chr1:152973571 G/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.29 -0.31 6.49e-16 Inflammatory skin disease; BRCA cis rs7552404 1.000 rs437298 chr1:76113770 T/C cg03433033 chr1:76189801 ACADM -0.76 -16.87 -0.56 4.13e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2153535 0.580 rs2327050 chr6:8440630 A/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.73e-18 Motion sickness; BRCA cis rs1552244 0.832 rs3732968 chr3:10013273 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.58 -10.74 -0.39 7.59e-25 Alzheimer's disease; BRCA cis rs6582630 0.615 rs12821226 chr12:38546406 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.28 -0.38 4.86e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs1865760 0.532 rs2794719 chr6:26088890 T/G cg17691542 chr6:26056736 HIST1H1C 0.55 11.8 0.42 3.17e-29 Height; BRCA cis rs2180341 1.000 rs9385419 chr6:127597591 A/G cg27446573 chr6:127587934 RNF146 0.88 20.71 0.63 2.59e-73 Breast cancer; BRCA cis rs7666738 0.791 rs4699324 chr4:98967496 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.58e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs9287719 0.967 rs12467642 chr2:10761484 G/A cg00105475 chr2:10696890 NA 0.44 10.26 0.38 5.78e-23 Prostate cancer; BRCA trans rs8002861 0.935 rs9533678 chr13:44463409 C/T cg17145862 chr1:211918768 LPGAT1 0.73 19.6 0.61 2.43e-67 Leprosy; BRCA cis rs10751667 0.560 rs10902267 chr11:1007831 T/C ch.11.42038R chr11:967971 AP2A2 0.47 14.24 0.49 3.59e-40 Alzheimer's disease (late onset); BRCA cis rs6724607 1.000 rs28452331 chr2:191471847 C/T cg11845111 chr2:191398756 TMEM194B -0.35 -7.91 -0.3 1.14e-14 Pulse pressure; BRCA cis rs8031584 0.958 rs11629793 chr15:31238423 G/A cg08704250 chr15:31115839 NA -0.36 -9.07 -0.34 1.42e-18 Huntington's disease progression; BRCA cis rs6088813 0.961 rs2425062 chr20:33923566 A/G cg14752227 chr20:34000481 UQCC 0.41 8.76 0.33 1.76e-17 Height; BRCA cis rs6582630 0.555 rs2197308 chr12:38281261 A/G cg26384229 chr12:38710491 ALG10B -0.44 -10.09 -0.37 2.61e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs7267979 0.903 rs1118963 chr20:25247449 G/A cg08601574 chr20:25228251 PYGB 0.41 9.57 0.35 2.2e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2204008 0.837 rs2892296 chr12:37969785 C/T cg26384229 chr12:38710491 ALG10B -0.58 -13.46 -0.47 1.49e-36 Bladder cancer; BRCA cis rs4285028 0.948 rs34543553 chr3:121675637 C/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.82 -0.39 3.64e-25 Multiple sclerosis; BRCA cis rs11785400 0.793 rs11543967 chr8:143739435 A/G cg24634471 chr8:143751801 JRK -0.48 -9.99 -0.37 6.09e-22 Schizophrenia; BRCA cis rs9462027 0.588 rs13215181 chr6:34759881 A/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.92 -0.3 1.07e-14 Systemic lupus erythematosus; BRCA cis rs6088580 0.634 rs6058051 chr20:33044862 G/A cg24642439 chr20:33292090 TP53INP2 0.54 11.61 0.42 2e-28 Glomerular filtration rate (creatinine); BRCA cis rs7772486 0.875 rs2748498 chr6:146319166 C/G cg13319975 chr6:146136371 FBXO30 -0.36 -8.19 -0.31 1.39e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs57143961 1 rs57143961 chr19:16533225 C/CT cg10248733 chr19:16607483 C19orf44;CALR3 -0.62 -10.62 -0.39 2.16e-24 Lymphocyte percentage of white cells; BRCA cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg11301795 chr4:187892539 NA 0.31 10.19 0.37 1.1e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs2742417 0.609 rs11709306 chr3:45773732 G/A cg04837898 chr3:45731254 SACM1L -0.38 -7.82 -0.3 2.24e-14 Response to anti-depressant treatment in major depressive disorder; BRCA cis rs9487051 0.872 rs9487038 chr6:109610152 T/C cg01475377 chr6:109611718 NA -0.6 -16.64 -0.55 6.41e-52 Reticulocyte fraction of red cells; BRCA trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg17830980 chr10:43048298 ZNF37B -0.57 -14.01 -0.48 4.47e-39 Extrinsic epigenetic age acceleration; BRCA cis rs3772130 0.923 rs13434284 chr3:121482842 C/A cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.75 0.39 7.12e-25 Cognitive performance; BRCA cis rs1552244 0.882 rs67762674 chr3:10014485 C/T cg16606324 chr3:10149918 C3orf24 0.49 9.66 0.36 1.06e-20 Alzheimer's disease; BRCA cis rs1801251 1.000 rs11555646 chr2:233599904 A/C cg08000102 chr2:233561755 GIGYF2 0.62 13.48 0.47 1.3e-36 Coronary artery disease; BRCA cis rs9337951 0.579 rs2505083 chr10:30335122 C/T cg00730780 chr10:30316187 KIAA1462 0.42 8.74 0.33 2.08e-17 Pulse pressure;Coronary artery disease; BRCA cis rs2032447 0.672 rs9379811 chr6:25955197 G/C cg03264133 chr6:25882463 NA -0.53 -11.42 -0.41 1.25e-27 Intelligence (multi-trait analysis); BRCA cis rs1801251 0.685 rs1515961 chr2:233623763 C/A cg25237894 chr2:233734115 C2orf82 0.3 8.68 0.32 3.17e-17 Coronary artery disease; BRCA cis rs10046574 0.561 rs11505984 chr7:135208359 G/A cg27474649 chr7:135195673 CNOT4 0.65 10.84 0.39 2.91e-25 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs6977660 0.652 rs10249291 chr7:19844448 C/G cg07541023 chr7:19748670 TWISTNB 0.71 11.09 0.4 2.95e-26 Thyroid stimulating hormone; BRCA cis rs6977660 0.714 rs7798760 chr7:19803487 T/C cg05791153 chr7:19748676 TWISTNB 0.57 10.52 0.38 5.76e-24 Thyroid stimulating hormone; BRCA cis rs7613875 0.641 rs2624845 chr3:50062437 C/A cg05623727 chr3:50126028 RBM5 -0.49 -11.8 -0.42 3.31e-29 Body mass index; BRCA cis rs1865760 1.000 rs1865760 chr6:25916979 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.47 0.38 8.71e-24 Height; BRCA cis rs9875589 0.509 rs6770928 chr3:14077189 G/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.89 0.33 6.08e-18 Ovarian reserve; BRCA cis rs9420 0.961 rs79260745 chr11:57612960 T/C cg19752551 chr11:57585705 CTNND1 -0.51 -12.6 -0.45 1.16e-32 Schizophrenia; BRCA cis rs13082711 0.555 rs73038733 chr3:27263537 C/G cg02860705 chr3:27208620 NA 0.55 10.85 0.39 2.74e-25 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6088813 1.000 rs6088812 chr20:33974163 T/A cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.1e-17 Height; BRCA cis rs7584330 0.518 rs77789507 chr2:238440972 C/T cg14458575 chr2:238380390 NA 0.54 8.09 0.3 3.03e-15 Prostate cancer; BRCA cis rs911186 0.786 rs3800307 chr6:27185792 A/T cg12292205 chr6:26970375 C6orf41 -0.65 -10.69 -0.39 1.18e-24 Autism spectrum disorder or schizophrenia; BRCA cis rs804292 0.695 rs804279 chr8:11623889 A/T cg26752888 chr8:11627280 NEIL2 0.58 11.98 0.43 5.61e-30 Alcohol dependence;Nicotine use; BRCA cis rs9443645 0.670 rs79209669 chr6:79719623 C/G cg05283184 chr6:79620031 NA -0.43 -11.0 -0.4 6.58e-26 Intelligence (multi-trait analysis); BRCA cis rs765787 0.530 rs4544188 chr15:45535393 C/A cg25801113 chr15:45476975 SHF 0.31 7.83 0.3 2e-14 Uric acid levels; BRCA cis rs4319547 0.695 rs55834409 chr12:122862560 C/G cg05707623 chr12:122985044 ZCCHC8 0.45 8.8 0.33 1.29e-17 Body mass index; BRCA cis rs6088580 0.634 rs6087580 chr20:32992592 A/G cg06115741 chr20:33292138 TP53INP2 -0.38 -8.34 -0.31 4.45e-16 Glomerular filtration rate (creatinine); BRCA cis rs3820928 0.804 rs4675125 chr2:227802499 T/C cg11843606 chr2:227700838 RHBDD1 -0.4 -8.72 -0.33 2.42e-17 Pulmonary function; BRCA cis rs858239 0.539 rs6461694 chr7:23187779 G/A cg23682824 chr7:23144976 KLHL7 0.37 9.64 0.36 1.27e-20 Cerebrospinal fluid biomarker levels; BRCA cis rs11051970 0.679 rs2651377 chr12:32556919 A/C cg24626660 chr12:32551988 NA 0.32 9.43 0.35 7.74e-20 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs62064224 0.714 rs16967266 chr17:30632274 G/A cg25809561 chr17:30822961 MYO1D 0.4 9.42 0.35 8.38e-20 Schizophrenia; BRCA cis rs1707322 0.656 rs3014210 chr1:46066608 A/G cg03146154 chr1:46216737 IPP -0.48 -10.79 -0.39 4.61e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs9325144 0.560 rs61929893 chr12:38653366 G/A cg23762105 chr12:34175262 ALG10 0.34 8.0 0.3 5.92e-15 Morning vs. evening chronotype; BRCA cis rs6987853 0.787 rs2923405 chr8:42448126 T/G cg09913449 chr8:42400586 C8orf40 0.38 7.92 0.3 1.03e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs1801251 0.711 rs2592117 chr2:233735693 C/T cg25237894 chr2:233734115 C2orf82 -0.45 -14.15 -0.49 1.02e-39 Coronary artery disease; BRCA cis rs1371614 0.632 rs3820823 chr2:27164806 C/T cg00617064 chr2:27272375 NA -0.31 -8.23 -0.31 1.03e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.41 -0.32 2.59e-16 Colorectal cancer; BRCA trans rs12310956 0.532 rs11052952 chr12:33988048 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.01 0.48 4.18e-39 Morning vs. evening chronotype; BRCA trans rs6582630 0.519 rs10880194 chr12:38302836 G/A cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs9933309 1.000 rs9933309 chr16:88844932 A/G cg04602696 chr16:88846723 FAM38A -0.44 -11.59 -0.42 2.5e-28 Glycated hemoglobin levels; BRCA cis rs9309711 0.643 rs4535074 chr2:3481637 A/G cg15541040 chr2:3486749 NA -0.47 -10.55 -0.39 4.34e-24 Neurofibrillary tangles; BRCA trans rs783540 0.592 rs2567632 chr15:83284804 A/G cg18393722 chr15:85113863 UBE2QP1 -0.32 -8.77 -0.33 1.66e-17 Schizophrenia; BRCA cis rs6952808 0.723 rs4721287 chr7:2028663 A/C cg00106254 chr7:1943704 MAD1L1 -0.46 -12.29 -0.44 2.59e-31 Bipolar disorder and schizophrenia; BRCA cis rs4363385 0.720 rs1970328 chr1:152975829 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.29 -0.34 2.4e-19 Inflammatory skin disease; BRCA cis rs11105298 0.891 rs11105312 chr12:89920733 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.55 -9.27 -0.34 2.92e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs11191205 0.644 rs7874 chr10:103361088 C/T cg15320455 chr10:103880129 LDB1 0.46 7.97 0.3 7.25e-15 Intelligence (multi-trait analysis); BRCA cis rs1580019 0.665 rs34147895 chr7:32531796 G/C cg14728415 chr7:32535168 LSM5;AVL9 0.41 8.71 0.33 2.63e-17 Cognitive ability; BRCA cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 18.9 0.6 1.21e-63 Smoking behavior; BRCA cis rs12600053 0.687 rs8063190 chr16:84849280 C/T cg09249803 chr16:84846936 NA 0.38 8.88 0.33 6.77e-18 Asthma (childhood onset); BRCA cis rs7264396 0.690 rs2425172 chr20:34443893 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.73 -15.19 -0.52 1.02e-44 Total cholesterol levels; BRCA cis rs2841277 0.616 rs1048257 chr14:105404384 T/C cg15352829 chr14:105391018 PLD4 -0.39 -12.46 -0.44 4.79e-32 Rheumatoid arthritis; BRCA cis rs6138458 0.701 rs6050255 chr20:25007089 A/G cg26195577 chr20:24973756 C20orf3 0.61 14.45 0.5 3.84e-41 Blood protein levels; BRCA cis rs35306767 0.903 rs10904577 chr10:922077 A/G cg25019033 chr10:957182 NA -0.41 -7.95 -0.3 8.62e-15 Eosinophil percentage of granulocytes; BRCA cis rs2997447 0.655 rs11247852 chr1:26383125 C/G cg19633962 chr1:26362018 EXTL1 0.53 9.21 0.34 4.59e-19 QRS complex (12-leadsum); BRCA trans rs9944715 0.954 rs4542747 chr18:43802169 C/T cg01718231 chr17:29326311 RNF135 -0.4 -8.08 -0.3 3.23e-15 Red cell distribution width;Mean corpuscular volume; BRCA cis rs10840133 1 rs10840133 chr11:8846369 G/A cg21881798 chr11:8931708 C11orf17;ST5 0.42 9.01 0.34 2.31e-18 Reticulocyte fraction of red cells; BRCA cis rs6028335 0.674 rs61213966 chr20:37621906 A/G cg16355469 chr20:37678765 NA 0.5 9.03 0.34 1.97e-18 Alcohol and nicotine co-dependence; BRCA cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg09658497 chr7:2847517 GNA12 -0.41 -8.67 -0.32 3.51e-17 Height; BRCA cis rs79839061 0.610 rs3736089 chr4:870118 G/A cg14530993 chr4:882597 GAK 0.6 9.78 0.36 3.96e-21 Intelligence (multi-trait analysis); BRCA cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg12573674 chr2:1569213 NA -0.58 -12.65 -0.45 6.98e-33 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs12497850 0.931 rs9755490 chr3:48871664 A/C cg07636037 chr3:49044803 WDR6 0.97 28.33 0.75 5.26e-115 Parkinson's disease; BRCA cis rs12579753 1.000 rs11115015 chr12:82174543 T/C cg07988820 chr12:82153109 PPFIA2 -0.59 -9.51 -0.35 3.9e-20 Resting heart rate; BRCA cis rs826838 0.967 rs826858 chr12:39116731 A/G cg26384229 chr12:38710491 ALG10B -0.61 -15.89 -0.53 3.76e-48 Heart rate; BRCA cis rs4363385 0.693 rs581447 chr1:153033269 A/G cg24667326 chr1:152973720 SPRR3 -0.31 -8.2 -0.31 1.28e-15 Inflammatory skin disease; BRCA cis rs6951245 0.872 rs75398423 chr7:1098414 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.63 12.02 0.43 3.77e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1153858 1.000 rs7167900 chr15:45639471 A/G cg21132104 chr15:45694354 SPATA5L1 0.7 15.39 0.52 1.14e-45 Homoarginine levels; BRCA cis rs6834538 0.964 rs2087110 chr4:113411791 T/C cg05166686 chr4:113558556 LARP7;C4orf21 0.36 8.31 0.31 5.7e-16 Free thyroxine concentration; BRCA cis rs2046867 0.819 rs34132129 chr3:72829100 A/G cg25664220 chr3:72788482 NA -0.5 -10.64 -0.39 1.86e-24 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs3818285 0.504 rs1973972 chr10:111651133 A/T cg00817464 chr10:111662876 XPNPEP1 0.33 8.9 0.33 5.81e-18 Superior crus of antihelix expression; BRCA cis rs17376456 0.825 rs67328989 chr5:93243133 T/A cg21475434 chr5:93447410 FAM172A 0.66 8.55 0.32 8.79e-17 Diabetic retinopathy; BRCA cis rs34779708 0.966 rs1148245 chr10:35511894 C/T cg03585969 chr10:35415529 CREM 0.44 9.14 0.34 8.21e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12425451 0.544 rs3741951 chr12:3147080 A/G cg05389053 chr12:3131226 TEAD4 0.42 8.22 0.31 1.16e-15 Narcolepsy with cataplexy; BRCA cis rs875971 0.798 rs57739047 chr7:65972566 A/T cg11764359 chr7:65958608 NA 0.77 17.36 0.57 1.4e-55 Aortic root size; BRCA cis rs1008375 1.000 rs2159584 chr4:17620568 G/A cg15017067 chr4:17643749 FAM184B 0.31 9.57 0.35 2.29e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11252926 0.537 rs6560836 chr10:444997 C/T cg16386425 chr10:429943 DIP2C -0.42 -8.91 -0.33 5.27e-18 Psychosis in Alzheimer's disease; BRCA cis rs7246657 0.722 rs35863684 chr19:38109777 C/T cg18154014 chr19:37997991 ZNF793 0.5 9.67 0.36 9.8e-21 Coronary artery calcification; BRCA cis rs9611565 0.694 rs202664 chr22:41813886 C/T cg06634786 chr22:41940651 POLR3H 0.51 9.4 0.35 9.28e-20 Vitiligo; BRCA cis rs9325144 0.647 rs11169258 chr12:39113040 C/T cg26384229 chr12:38710491 ALG10B -0.48 -11.12 -0.4 2.21e-26 Morning vs. evening chronotype; BRCA cis rs61931739 0.534 rs1490109 chr12:34064077 T/C cg06521331 chr12:34319734 NA -0.62 -12.13 -0.43 1.24e-30 Morning vs. evening chronotype; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg02675527 chr2:114030824 PAX8;LOC440839 -0.44 -10.36 -0.38 2.44e-23 Lymphocyte counts; BRCA cis rs2762353 0.935 rs3799340 chr6:25762646 C/T cg12310025 chr6:25882481 NA 0.51 12.0 0.43 4.48e-30 Blood metabolite levels; BRCA trans rs61931739 0.534 rs2389276 chr12:34097891 T/C cg26384229 chr12:38710491 ALG10B 0.56 12.16 0.43 9.46e-31 Morning vs. evening chronotype; BRCA cis rs7945718 0.934 rs10831907 chr11:12790875 C/T cg25843174 chr11:12811716 TEAD1 -0.24 -9.18 -0.34 5.72e-19 Educational attainment (years of education); BRCA trans rs7618501 0.571 rs2240329 chr3:50107512 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.32 -9.01 -0.34 2.3e-18 Intelligence (multi-trait analysis); BRCA cis rs7264396 0.563 rs73902913 chr20:34432784 A/G cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -10.66 -0.39 1.56e-24 Total cholesterol levels; BRCA cis rs2281845 0.826 rs4915484 chr1:201076917 C/G cg06714761 chr1:201096289 NA 0.29 7.83 0.3 2.05e-14 Permanent tooth development; BRCA cis rs2404602 0.647 rs34103231 chr15:76912690 A/G cg23625390 chr15:77176239 SCAPER -0.54 -12.55 -0.44 1.98e-32 Blood metabolite levels; BRCA cis rs1843834 0.898 rs2015099 chr2:225519915 T/C cg22455342 chr2:225449267 CUL3 0.35 8.57 0.32 7.7e-17 IgE levels in asthmatics (D.p. specific); BRCA cis rs2012796 1.000 rs12436146 chr14:81821282 A/G cg02996355 chr14:81879375 NA 0.49 9.75 0.36 4.77e-21 Night sleep phenotypes; BRCA cis rs2276314 1.000 rs8086395 chr18:33564592 C/G cg19628046 chr18:33552617 C18orf21 0.56 11.5 0.41 6.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs17253792 0.659 rs34330219 chr14:56017375 G/A cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs2075371 0.966 rs2544224 chr7:133995832 A/G cg02659138 chr7:134003124 SLC35B4 0.34 10.78 0.39 5.39e-25 Mean platelet volume; BRCA cis rs61931739 0.500 rs6488221 chr12:34525671 A/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.3e-22 Morning vs. evening chronotype; BRCA cis rs6089584 1.000 rs6142910 chr20:60562181 C/A cg13770153 chr20:60521292 NA -0.45 -10.81 -0.39 4.09e-25 Body mass index; BRCA cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg14458575 chr2:238380390 NA 0.57 12.95 0.46 3.02e-34 Prostate cancer; BRCA cis rs1030877 0.515 rs920217 chr2:105904662 C/T cg02079111 chr2:105885981 TGFBRAP1 -0.64 -12.29 -0.44 2.52e-31 Obesity-related traits; BRCA cis rs7772486 0.875 rs2777484 chr6:146334162 A/G cg13319975 chr6:146136371 FBXO30 -0.36 -8.38 -0.31 3.25e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs3806843 0.966 rs2563264 chr5:140137503 T/G cg16179182 chr5:140090404 VTRNA1-1 0.41 9.51 0.35 3.93e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs2576037 0.562 rs9959877 chr18:44522293 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.42 0.5 4.89e-41 Personality dimensions; BRCA cis rs757110 0.770 rs2051772 chr11:17389850 G/A cg04705435 chr11:17411270 KCNJ11 0.44 9.4 0.35 9.82e-20 Type 2 diabetes; BRCA cis rs11690935 0.959 rs66835971 chr2:172677459 G/A cg13550731 chr2:172543902 DYNC1I2 -0.9 -29.3 -0.76 2.97e-120 Schizophrenia; BRCA cis rs17270561 1.000 rs79867288 chr6:25828416 A/G cg17691542 chr6:26056736 HIST1H1C 0.76 13.47 0.47 1.44e-36 Iron status biomarkers; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg27588902 chr6:42928151 GNMT -0.31 -10.32 -0.38 3.3e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs13256369 0.760 rs7839473 chr8:8575836 C/T cg17143192 chr8:8559678 CLDN23 0.53 10.23 0.38 7.52e-23 Obesity-related traits; BRCA cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.39 -0.44 9.32e-32 Chronic sinus infection; BRCA cis rs9341808 0.754 rs978814 chr6:80959912 G/T cg08355045 chr6:80787529 NA 0.37 9.53 0.35 3.26e-20 Sitting height ratio; BRCA cis rs332507 0.673 rs2242426 chr3:124398031 A/G cg05980111 chr3:124395277 KALRN 0.36 8.4 0.32 2.92e-16 Plateletcrit; BRCA cis rs2075371 0.796 rs12154724 chr7:133943443 G/A cg11752832 chr7:134001865 SLC35B4 0.49 11.02 0.4 5.53e-26 Mean platelet volume; BRCA cis rs3818285 0.679 rs552419 chr10:111630883 G/T cg00817464 chr10:111662876 XPNPEP1 0.46 15.14 0.51 1.78e-44 Superior crus of antihelix expression; BRCA cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg10802521 chr3:52805072 NEK4 -0.33 -9.02 -0.34 2.22e-18 Bipolar disorder; BRCA trans rs9858542 0.953 rs7623659 chr3:49414791 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.05 -0.34 1.73e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9438901 0.655 rs609320 chr1:25717365 C/G cg12421513 chr1:25599066 RHD -0.47 -7.95 -0.3 8.26e-15 Red cell distribution width; BRCA cis rs17376456 0.825 rs13357713 chr5:93145423 T/C cg21475434 chr5:93447410 FAM172A 0.67 8.74 0.33 2.02e-17 Diabetic retinopathy; BRCA cis rs4332037 0.805 rs10278591 chr7:1921362 A/G cg23422044 chr7:1970798 MAD1L1 0.69 15.25 0.52 5.16e-45 Bipolar disorder; BRCA cis rs1008375 0.966 rs4235389 chr4:17696280 A/G cg02297831 chr4:17616191 MED28 0.34 8.07 0.3 3.6e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7903847 0.642 rs2275089 chr10:99141205 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.66 -0.32 3.88e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs514406 0.570 rs1332776 chr1:53189816 C/T cg16325326 chr1:53192061 ZYG11B 0.79 20.91 0.64 2.3e-74 Monocyte count; BRCA cis rs1005277 0.579 rs2474567 chr10:38382492 C/T cg00409905 chr10:38381863 ZNF37A -0.52 -11.13 -0.4 1.98e-26 Extrinsic epigenetic age acceleration; BRCA cis rs938554 0.513 rs3733588 chr4:9997303 A/G cg00071950 chr4:10020882 SLC2A9 -0.38 -8.09 -0.3 3.1e-15 Blood metabolite levels; BRCA cis rs2070488 0.775 rs7644530 chr3:38558316 C/T cg24069376 chr3:38537580 EXOG -0.33 -9.43 -0.35 7.22e-20 Electrocardiographic conduction measures; BRCA cis rs7246657 0.678 rs2972446 chr19:38129893 G/A cg14683738 chr19:37701593 ZNF585B -0.46 -7.91 -0.3 1.16e-14 Coronary artery calcification; BRCA cis rs752010 0.841 rs7519983 chr1:42083369 C/T cg06885757 chr1:42089581 HIVEP3 0.24 9.25 0.34 3.19e-19 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs875971 1.000 rs778710 chr7:65854834 T/C cg11764359 chr7:65958608 NA 0.8 19.51 0.61 7.85e-67 Aortic root size; BRCA cis rs7677751 0.848 rs7673625 chr4:55088586 C/T cg17187183 chr4:55093834 PDGFRA 0.44 9.2 0.34 5.19e-19 Corneal astigmatism; BRCA cis rs9399135 0.967 rs4895436 chr6:135295001 G/A cg24558204 chr6:135376177 HBS1L 0.46 12.59 0.45 1.23e-32 Red blood cell count; BRCA cis rs3858526 0.514 rs1530973 chr11:5861449 C/T cg13902645 chr11:5959945 NA -0.47 -10.08 -0.37 2.94e-22 DNA methylation (variation); BRCA cis rs17376456 0.757 rs1031424 chr5:93139706 G/C cg21475434 chr5:93447410 FAM172A 0.67 8.74 0.33 2.02e-17 Diabetic retinopathy; BRCA cis rs13256369 0.851 rs13258283 chr8:8563630 T/C cg17143192 chr8:8559678 CLDN23 0.57 11.08 0.4 3.3e-26 Obesity-related traits; BRCA cis rs10256972 0.516 rs12702081 chr7:1141528 T/C cg07308232 chr7:1071921 C7orf50 -0.38 -7.87 -0.3 1.48e-14 Longevity;Endometriosis; BRCA cis rs17384381 0.906 rs2300639 chr1:85823676 T/A cg16011679 chr1:85725395 C1orf52 0.53 8.05 0.3 4e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs4727027 0.901 rs11760293 chr7:148811725 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 10.97 0.4 9.02e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg18402987 chr7:1209562 NA 0.42 8.02 0.3 5.22e-15 Longevity;Endometriosis; BRCA cis rs7572733 0.576 rs6734781 chr2:198759973 G/A cg00792783 chr2:198669748 PLCL1 0.46 10.07 0.37 3.08e-22 Dermatomyositis; BRCA cis rs7829975 0.606 rs7819827 chr8:8797055 G/C cg15556689 chr8:8085844 FLJ10661 -0.41 -11.17 -0.4 1.37e-26 Mood instability; BRCA cis rs853679 0.517 rs16893666 chr6:28054707 C/T cg02631126 chr6:28058918 ZSCAN12L1 -0.27 -7.85 -0.3 1.71e-14 Depression; BRCA cis rs877282 1.000 rs11253367 chr10:773389 G/A cg17470449 chr10:769945 NA 0.52 9.74 0.36 5.5e-21 Uric acid levels; BRCA cis rs1949733 0.628 rs1543246 chr4:8504909 A/T cg11789530 chr4:8429930 ACOX3 0.57 14.54 0.5 1.42e-41 Response to antineoplastic agents; BRCA cis rs1005277 0.579 rs2008449 chr10:38414204 A/T cg00409905 chr10:38381863 ZNF37A 0.57 12.55 0.44 1.91e-32 Extrinsic epigenetic age acceleration; BRCA cis rs367615 0.918 rs4270746 chr5:108876839 T/C cg17395555 chr5:108820864 NA 0.37 9.42 0.35 8.11e-20 Colorectal cancer (SNP x SNP interaction); BRCA cis rs8072100 0.840 rs12452796 chr17:45479733 G/T cg08085267 chr17:45401833 C17orf57 0.67 14.76 0.5 1.17e-42 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2153535 0.623 rs6597338 chr6:8533508 A/C cg07606381 chr6:8435919 SLC35B3 0.64 14.21 0.49 4.83e-40 Motion sickness; BRCA cis rs4689388 0.926 rs10010131 chr4:6292915 A/G cg00701064 chr4:6280414 WFS1 0.68 17.67 0.57 3.6e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7086627 0.515 rs11202957 chr10:82209592 A/G cg00277334 chr10:82204260 NA -0.85 -24.9 -0.7 3.41e-96 Post bronchodilator FEV1; BRCA cis rs4812048 0.689 rs151360 chr20:57613373 T/C cg14073986 chr20:57617431 SLMO2 0.49 8.33 0.31 4.99e-16 Mean platelet volume; BRCA cis rs12497850 0.931 rs7628719 chr3:48995487 C/T cg07636037 chr3:49044803 WDR6 0.94 27.36 0.73 1.12e-109 Parkinson's disease; BRCA cis rs11098499 0.754 rs11724409 chr4:120252361 A/G cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs4862750 0.914 rs11943333 chr4:187872455 A/G cg03452623 chr4:187889614 NA -0.28 -9.53 -0.35 3.31e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs7811142 1.000 rs6962151 chr7:100028484 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.64 11.15 0.4 1.72e-26 Platelet count; BRCA cis rs1577917 0.958 rs11755642 chr6:86450066 A/C cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.36 -8.78 -0.33 1.51e-17 Response to antipsychotic treatment; BRCA trans rs35110281 0.811 rs1122873 chr21:45044672 G/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.32 0.38 3.23e-23 Mean corpuscular volume; BRCA cis rs6570726 0.764 rs76635693 chr6:145834070 T/C cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs7264396 0.616 rs6142476 chr20:34581216 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.58 -12.42 -0.44 6.72e-32 Total cholesterol levels; BRCA cis rs7662987 0.517 rs1154406 chr4:100008494 T/C cg13256891 chr4:100009986 ADH5 0.55 10.27 0.38 5.22e-23 Smoking initiation; BRCA cis rs10751667 0.643 rs11246344 chr11:933783 A/C cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.47e-49 Alzheimer's disease (late onset); BRCA cis rs1005277 0.579 rs2505196 chr10:38393563 G/A cg25427524 chr10:38739819 LOC399744 -0.69 -16.76 -0.55 1.62e-52 Extrinsic epigenetic age acceleration; BRCA cis rs2806561 0.765 rs2806565 chr1:23507068 A/G cg12483005 chr1:23474871 LUZP1 0.46 10.35 0.38 2.53e-23 Height; BRCA cis rs1865721 0.728 rs8087297 chr18:73136221 T/A cg26385618 chr18:73139727 C18orf62 -0.43 -10.54 -0.38 4.63e-24 Intelligence; BRCA cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg11657440 chr19:46296263 DMWD -0.57 -13.53 -0.47 7.15e-37 Coronary artery disease; BRCA cis rs6545883 0.542 rs7584500 chr2:61692115 T/C cg15711740 chr2:61764176 XPO1 -0.32 -7.81 -0.3 2.29e-14 Tuberculosis; BRCA cis rs4819052 0.851 rs28676615 chr21:46676576 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.6 13.05 0.46 1.08e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs921968 0.565 rs35594672 chr2:219589280 T/A cg02176678 chr2:219576539 TTLL4 -0.4 -10.97 -0.4 8.94e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs2153535 0.580 rs9328479 chr6:8519646 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.53 0.38 5.1900000000000004e-24 Motion sickness; BRCA cis rs7615952 0.576 rs4646763 chr3:125822129 G/A cg18479299 chr3:125709523 NA -0.54 -8.36 -0.31 4.05e-16 Blood pressure (smoking interaction); BRCA cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg24692254 chr21:30365293 RNF160 -0.46 -10.25 -0.38 6.51e-23 Dental caries; BRCA trans rs6952808 0.543 rs4719436 chr7:2141239 G/A cg04565464 chr8:145669602 NFKBIL2 0.43 9.82 0.36 2.6e-21 Bipolar disorder and schizophrenia; BRCA cis rs9649465 1.000 rs4588795 chr7:123349924 A/G cg04330084 chr7:123175371 IQUB 0.3 8.36 0.31 3.85e-16 Migraine; BRCA cis rs10242455 0.702 rs73403247 chr7:99088730 G/A cg18809830 chr7:99032528 PTCD1 -0.62 -8.68 -0.32 3.31e-17 Blood metabolite levels; BRCA cis rs490234 0.871 rs4837019 chr9:128276081 C/G cg14078157 chr9:128172775 NA -0.4 -9.25 -0.34 3.23e-19 Mean arterial pressure; BRCA cis rs9733 0.635 rs486836 chr1:150875967 A/T cg18016565 chr1:150552671 MCL1 -0.36 -8.14 -0.31 2e-15 Tonsillectomy; BRCA cis rs62103177 0.525 rs8086024 chr18:77746623 A/G cg02751453 chr18:77725136 HSBP1L1 0.36 8.87 0.33 7e-18 Opioid sensitivity; BRCA trans rs11098499 0.821 rs3775852 chr4:120454556 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs909002 0.849 rs1464306 chr1:32076261 T/C cg13919466 chr1:32135498 COL16A1 -0.26 -8.75 -0.33 1.94e-17 Intelligence (multi-trait analysis); BRCA cis rs514406 0.683 rs10157120 chr1:53210888 A/G cg24675658 chr1:53192096 ZYG11B -0.66 -14.5 -0.5 2.16e-41 Monocyte count; BRCA cis rs826838 0.967 rs7963716 chr12:38876090 C/T cg26384229 chr12:38710491 ALG10B 0.84 21.62 0.65 3.14e-78 Heart rate; BRCA cis rs11252926 0.563 rs10795103 chr10:451849 C/A cg18196295 chr10:418757 DIP2C 0.49 11.87 0.43 1.6800000000000001e-29 Psychosis in Alzheimer's disease; BRCA trans rs2832077 0.943 rs2272701 chr21:30190907 C/T cg14791747 chr16:20752902 THUMPD1 0.4 9.35 0.35 1.51e-19 Cognitive test performance; BRCA cis rs4862750 0.794 rs7692427 chr4:187901727 G/A cg07414643 chr4:187882934 NA 0.28 9.67 0.36 9.82e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.811 rs1122873 chr21:45044672 G/C cg21573476 chr21:45109991 RRP1B -0.34 -8.78 -0.33 1.44e-17 Mean corpuscular volume; BRCA cis rs7772486 0.790 rs1854900 chr6:146331382 G/A cg13319975 chr6:146136371 FBXO30 -0.37 -8.37 -0.31 3.51e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs11722228 1.000 rs11722228 chr4:9915741 C/T cg00071950 chr4:10020882 SLC2A9 0.38 8.05 0.3 4.18e-15 Gout;Urate levels;Serum uric acid levels; BRCA cis rs10089 0.953 rs10223203 chr5:127527646 A/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.6 -13.68 -0.48 1.46e-37 Ileal carcinoids; BRCA cis rs3733585 0.673 rs4580649 chr4:9948461 G/A cg00071950 chr4:10020882 SLC2A9 -0.45 -10.51 -0.38 6.16e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs875971 0.895 rs6460300 chr7:65952924 A/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs2439831 0.702 rs9989313 chr15:44152817 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.84 0.45 9.45e-34 Lung cancer in ever smokers; BRCA cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg24558204 chr6:135376177 HBS1L 0.48 13.24 0.46 1.53e-35 High light scatter reticulocyte percentage of red cells; BRCA cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg19482086 chr6:160211437 TCP1;MRPL18 0.67 16.65 0.55 5.52e-52 Age-related macular degeneration (geographic atrophy); BRCA cis rs12310956 0.532 rs1852226 chr12:33962940 G/A cg06521331 chr12:34319734 NA -0.54 -10.97 -0.4 9.24e-26 Morning vs. evening chronotype; BRCA cis rs11626933 0.959 rs2149649 chr14:90774974 A/G cg04374321 chr14:90722782 PSMC1 -0.41 -8.44 -0.32 2.16e-16 Gut microbiota (bacterial taxa); BRCA cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg26597838 chr10:835615 NA 0.89 13.85 0.48 2.47e-38 Eosinophil percentage of granulocytes; BRCA cis rs2455799 0.613 rs7617039 chr3:15800740 A/G cg16303742 chr3:15540471 COLQ 0.35 8.09 0.3 3.01e-15 Mean platelet volume; BRCA cis rs6912958 0.559 rs6921504 chr6:88058972 A/G cg08069147 chr6:88032118 GJB7;C6orf162 0.55 11.85 0.42 1.95e-29 Monocyte percentage of white cells; BRCA trans rs1994135 0.594 rs10772096 chr12:33732869 A/G cg26384229 chr12:38710491 ALG10B 0.39 8.84 0.33 8.9e-18 Resting heart rate; BRCA trans rs4596713 0.508 rs12056979 chr9:71778946 A/G cg16512924 chr15:28394682 HERC2 0.45 10.58 0.39 3.12e-24 Headache; BRCA cis rs1971762 0.542 rs12303370 chr12:54091807 A/C cg23533419 chr12:54090519 NA -0.32 -8.12 -0.31 2.49e-15 Height; BRCA cis rs780096 0.565 rs8179252 chr2:27746832 A/C cg17158414 chr2:27665306 KRTCAP3 -0.32 -8.08 -0.3 3.3e-15 Total body bone mineral density; BRCA cis rs7666738 0.830 rs4443293 chr4:99063120 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.6e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs11025559 0.643 rs11025570 chr11:20481109 T/A cg19653624 chr11:20408972 PRMT3 -0.46 -8.98 -0.33 3e-18 Pursuit maintenance gain; BRCA cis rs17345786 0.906 rs12638137 chr3:101150964 C/T cg11279151 chr3:101281821 RG9MTD1 -0.5 -9.49 -0.35 4.43e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13126279 chr21:47581558 C21orf56 0.48 10.68 0.39 1.25e-24 Testicular germ cell tumor; BRCA cis rs7918232 0.891 rs10443987 chr10:27375377 A/T cg14442939 chr10:27389572 ANKRD26 0.69 11.43 0.41 1.2e-27 Breast cancer; BRCA cis rs12618769 0.601 rs56118505 chr2:99139832 T/G cg10123293 chr2:99228465 UNC50 0.41 7.91 0.3 1.14e-14 Bipolar disorder; BRCA cis rs6582630 0.555 rs4601853 chr12:38435569 G/A cg26384229 chr12:38710491 ALG10B 0.74 17.53 0.57 1.85e-56 Drug-induced liver injury (flucloxacillin); BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg22800045 chr5:56110881 MAP3K1 0.68 12.93 0.46 3.81e-34 Initial pursuit acceleration; BRCA cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs1003719 0.715 rs1981432 chr21:38541356 G/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.31 -0.49 1.67e-40 Eye color traits; BRCA cis rs34172651 0.517 rs2287783 chr16:24831727 C/T cg06028605 chr16:24865363 SLC5A11 0.44 9.77 0.36 4.08e-21 Intelligence (multi-trait analysis); BRCA cis rs912057 0.901 rs744056 chr6:6733540 A/G cg06612196 chr6:6737390 NA 0.44 9.82 0.36 2.63e-21 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg06108461 chr20:60628389 TAF4 -0.8 -17.52 -0.57 2.09e-56 Body mass index; BRCA trans rs3733585 0.699 rs6823361 chr4:9963127 A/G cg26043149 chr18:55253948 FECH -0.37 -8.12 -0.31 2.34e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.41 -0.35 9.07e-20 Alzheimer's disease; BRCA cis rs4808199 0.948 rs968525 chr19:19459215 C/T cg01262667 chr19:19385393 TM6SF2 0.39 8.37 0.31 3.7e-16 Nonalcoholic fatty liver disease; BRCA cis rs9341808 0.527 rs7453746 chr6:80810013 T/G cg08355045 chr6:80787529 NA 0.43 11.36 0.41 2.38e-27 Sitting height ratio; BRCA cis rs67478160 0.572 rs8015603 chr14:104293678 C/G cg26031613 chr14:104095156 KLC1 -0.43 -8.41 -0.32 2.62e-16 Schizophrenia; BRCA cis rs7618501 0.521 rs2883059 chr3:49902160 C/T cg14019146 chr3:50243930 SLC38A3 0.39 9.5 0.35 4.19e-20 Intelligence (multi-trait analysis); BRCA trans rs1459104 0.866 rs28873990 chr11:54812748 G/A cg15704280 chr7:45808275 SEPT13 0.63 8.25 0.31 8.87e-16 Body mass index; BRCA cis rs60843830 1.000 rs7595075 chr2:264019 C/A cg00108164 chr2:264199 ACP1;SH3YL1 0.71 14.46 0.5 3.31e-41 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs801193 0.591 rs721717 chr7:66130292 G/T cg11764359 chr7:65958608 NA -0.73 -16.06 -0.54 4.98e-49 Aortic root size; BRCA cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.4 8.19 0.31 1.47e-15 Personality dimensions; BRCA cis rs873946 0.564 rs35831787 chr10:134546346 T/C cg26818010 chr10:134567672 INPP5A -0.64 -13.44 -0.47 1.96e-36 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs6089829 0.851 rs4809460 chr20:61661355 T/C cg08564027 chr20:61660810 NA 0.85 22.66 0.67 6.95e-84 Prostate cancer (SNP x SNP interaction); BRCA cis rs1215050 0.740 rs10025482 chr4:99053277 T/C cg05340658 chr4:99064831 C4orf37 0.5 11.58 0.42 2.87e-28 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs12971120 1.000 rs2278162 chr18:72175814 A/G cg26446133 chr18:72167187 CNDP2 -0.75 -14.61 -0.5 6.08e-42 Refractive error; BRCA cis rs2115536 0.967 rs4778734 chr15:80210851 A/G cg00225070 chr15:80189496 MTHFS 0.41 10.04 0.37 3.87e-22 Eosinophil counts;Eosinophil percentage of white cells;Sum eosinophil basophil counts;Eosinophil percentage of granulocytes;Neutrophil percentage of granulocytes; BRCA cis rs9818758 0.607 rs5030795 chr3:49141116 C/T cg00383909 chr3:49044727 WDR6 0.92 15.55 0.52 1.69e-46 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs926392 0.589 rs2019032 chr20:37680326 C/A cg16355469 chr20:37678765 NA 0.51 12.31 0.44 2.15e-31 Dialysis-related mortality; BRCA cis rs7833790 0.660 rs67666182 chr8:82772037 A/G cg27398817 chr8:82754497 SNX16 0.34 7.89 0.3 1.35e-14 Diastolic blood pressure; BRCA cis rs62064224 0.589 rs2285428 chr17:30820176 C/T cg25809561 chr17:30822961 MYO1D -0.43 -9.68 -0.36 8.92e-21 Schizophrenia; BRCA cis rs4363385 0.747 rs6665575 chr1:152960506 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.52 -0.32 1.13e-16 Inflammatory skin disease; BRCA trans rs1005277 0.522 rs289648 chr10:37971837 T/C cg17830980 chr10:43048298 ZNF37B -0.42 -9.72 -0.36 6.43e-21 Extrinsic epigenetic age acceleration; BRCA cis rs9341808 0.718 rs9352803 chr6:80864667 G/T cg08355045 chr6:80787529 NA 0.37 9.34 0.35 1.63e-19 Sitting height ratio; BRCA cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.95 0.43 7.75e-30 Personality dimensions; BRCA cis rs7613875 0.580 rs12634780 chr3:50043341 A/T cg24110177 chr3:50126178 RBM5 0.53 15.55 0.52 1.82e-46 Body mass index; BRCA cis rs10927875 0.541 rs1739844 chr1:16343322 T/C cg06159980 chr1:16340746 HSPB7 -0.38 -8.82 -0.33 1.11e-17 Dilated cardiomyopathy; BRCA cis rs67460515 0.892 rs34016896 chr3:160992864 C/T cg17135325 chr3:160939158 NMD3 0.41 7.93 0.3 1.01e-14 Parkinson's disease; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg24101359 chr6:42928495 GNMT 0.63 15.5 0.52 3.2e-46 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11098499 0.954 rs4345162 chr4:120312959 G/A cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.56 -8.93 -0.33 4.67e-18 Alzheimer's disease; BRCA cis rs78761021 0.867 rs8077150 chr17:9788769 C/T cg26853458 chr17:9805074 RCVRN 0.37 8.36 0.31 4.06e-16 Type 2 diabetes; BRCA trans rs7786808 0.525 rs10253961 chr7:158194858 G/A cg02030672 chr11:45687055 CHST1 -0.4 -9.01 -0.34 2.42e-18 Obesity-related traits; BRCA cis rs6835098 0.962 rs10014010 chr4:174083230 C/T cg08422745 chr4:174089978 GALNT7 -0.8 -18.4 -0.59 5.71e-61 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs11105298 0.891 rs10858903 chr12:89927972 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.56 -9.28 -0.34 2.56e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7572733 0.534 rs2060488 chr2:198751637 T/G cg00792783 chr2:198669748 PLCL1 0.47 10.25 0.38 6.42e-23 Dermatomyositis; BRCA cis rs7412746 0.658 rs7521719 chr1:150913134 G/A cg15448220 chr1:150897856 SETDB1 0.35 7.9 0.3 1.26e-14 Melanoma; BRCA cis rs7131987 0.683 rs12366505 chr12:29474110 C/T cg09582351 chr12:29534625 ERGIC2 -0.43 -9.85 -0.36 2.03e-21 QT interval; BRCA cis rs6694270 0.913 rs3935030 chr1:19116956 C/T cg19637330 chr1:19110922 NA -0.49 -8.86 -0.33 8.01e-18 Drug-induced liver injury (nitrofurantoin); BRCA cis rs16858210 0.520 rs34190894 chr3:183550412 A/T cg03417191 chr3:183542750 MAP6D1 -0.68 -10.61 -0.39 2.5300000000000002e-24 Menopause (age at onset); BRCA cis rs1008375 0.931 rs2098151 chr4:17577490 T/C cg16339924 chr4:17578868 LAP3 0.66 16.7 0.55 3.21e-52 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6788895 1.000 rs74950732 chr3:150482621 C/T cg09723797 chr3:150481914 SIAH2 0.72 8.6 0.32 6.26e-17 Breast cancer; BRCA cis rs9467773 0.596 rs2451751 chr6:26646714 T/C cg11502198 chr6:26597334 ABT1 0.56 12.02 0.43 3.88e-30 Intelligence (multi-trait analysis); BRCA cis rs9818758 0.607 rs34326553 chr3:49134429 A/G cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs11190604 0.767 rs10883478 chr10:102162852 C/T cg07080220 chr10:102295463 HIF1AN 0.48 10.21 0.37 8.66e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg04944784 chr2:26401820 FAM59B -0.69 -11.36 -0.41 2.25e-27 Gut microbiome composition (summer); BRCA cis rs9549328 0.731 rs7983602 chr13:113620482 A/G cg22951483 chr13:113628068 MCF2L -0.34 -8.02 -0.3 5.04e-15 Systolic blood pressure; BRCA cis rs6977660 0.714 rs17141882 chr7:19790217 C/T cg05791153 chr7:19748676 TWISTNB 0.58 10.59 0.39 2.98e-24 Thyroid stimulating hormone; BRCA cis rs3733585 0.699 rs7699609 chr4:9961059 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.59 -0.39 3.05e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7011049 1.000 rs72648409 chr8:53857307 T/C cg26025543 chr8:53854495 NA 0.55 9.5 0.35 4.24e-20 Systolic blood pressure; BRCA cis rs637571 0.546 rs11227309 chr11:65584512 A/C cg26695010 chr11:65641043 EFEMP2 0.37 8.13 0.31 2.31e-15 Eosinophil percentage of white cells; BRCA cis rs1707322 0.964 rs12067716 chr1:46434428 T/A cg06784218 chr1:46089804 CCDC17 0.5 11.67 0.42 1.14e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg03929089 chr4:120376271 NA -0.66 -12.09 -0.43 1.9e-30 Coronary artery disease; BRCA cis rs4073582 0.595 rs801734 chr11:65931216 T/C cg14036092 chr11:66035641 RAB1B 0.4 10.76 0.39 6.55e-25 Gout; BRCA cis rs12760731 0.565 rs12406779 chr1:178088936 C/G cg00404053 chr1:178313656 RASAL2 0.66 8.07 0.3 3.41e-15 Obesity-related traits; BRCA cis rs10197940 0.571 rs13393021 chr2:152413258 A/C cg19508488 chr2:152266495 RIF1 0.49 10.65 0.39 1.73e-24 Lung cancer; BRCA cis rs8062405 1.000 rs8055982 chr16:28881202 A/C cg09754948 chr16:28834200 ATXN2L 0.45 8.92 0.33 5.02e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs936229 0.813 rs2301249 chr15:75092384 T/C cg14664628 chr15:75095509 CSK -0.95 -28.82 -0.75 1.21e-117 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA trans rs3960554 0.932 rs60717745 chr7:75846083 C/G cg19862616 chr7:65841803 NCRNA00174 0.59 11.0 0.4 6.51e-26 Eotaxin levels; BRCA cis rs1865760 0.892 rs2328903 chr6:25935765 T/C cg16482183 chr6:26056742 HIST1H1C 0.51 10.41 0.38 1.45e-23 Height; BRCA trans rs8002861 0.935 rs9525865 chr13:44459647 A/T cg17145862 chr1:211918768 LPGAT1 0.73 19.38 0.61 3.68e-66 Leprosy; BRCA cis rs9837602 0.935 rs56233205 chr3:99821679 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 8.69 0.33 3.01e-17 Breast cancer; BRCA cis rs736408 0.521 rs13074853 chr3:52779801 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.85 0.45 8.83e-34 Bipolar disorder; BRCA cis rs16976116 0.803 rs28590021 chr15:55490993 C/T cg11288833 chr15:55489084 RSL24D1 0.47 10.61 0.39 2.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4819052 0.851 rs2236445 chr21:46678453 T/C cg06618935 chr21:46677482 NA -0.35 -7.85 -0.3 1.75e-14 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2645694 0.651 rs2703144 chr4:77830505 C/G cg06046430 chr4:77819534 ANKRD56 0.58 12.69 0.45 4.5e-33 Emphysema distribution in smoking; BRCA cis rs13118159 0.573 rs7664763 chr4:1352305 A/G cg19318889 chr4:1322082 MAEA 0.57 11.78 0.42 4.14e-29 Longevity; BRCA cis rs9348729 1 rs9348729 chr6:26664268 T/C cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.3 -8.81 -0.33 1.2e-17 Intelligence (multi-trait analysis); BRCA cis rs2836950 0.501 rs2070865 chr21:40715519 C/T cg11890956 chr21:40555474 PSMG1 -0.55 -11.8 -0.42 3.26e-29 Menarche (age at onset); BRCA cis rs763014 0.932 rs2269559 chr16:682297 T/C cg07343612 chr16:622815 PIGQ -0.66 -21.19 -0.64 6.61e-76 Height; BRCA cis rs17253792 0.822 rs75763956 chr14:56071176 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.59 8.12 0.31 2.46e-15 Putamen volume; BRCA cis rs3099143 1.000 rs3099142 chr15:77104909 C/T cg21673338 chr15:77095150 SCAPER -0.53 -9.4 -0.35 9.79e-20 Recalcitrant atopic dermatitis; BRCA cis rs495337 0.736 rs967305 chr20:48459946 G/C cg17835207 chr20:48524531 SPATA2 0.5 10.94 0.4 1.22e-25 Psoriasis; BRCA cis rs6598955 0.671 rs12129482 chr1:26623641 C/T cg04990556 chr1:26633338 UBXN11 0.55 9.24 0.34 3.56e-19 Obesity-related traits; BRCA cis rs66887589 0.777 rs2017058 chr4:120257739 T/C cg09307838 chr4:120376055 NA 0.44 9.63 0.36 1.43e-20 Diastolic blood pressure; BRCA cis rs734999 0.967 rs6667605 chr1:2502780 C/T cg20673091 chr1:2541236 MMEL1 0.33 8.51 0.32 1.27e-16 Ulcerative colitis; BRCA trans rs61931739 0.500 rs11053198 chr12:34444013 G/C cg26384229 chr12:38710491 ALG10B 0.57 13.16 0.46 3.66e-35 Morning vs. evening chronotype; BRCA cis rs9790314 0.791 rs6809256 chr3:161026513 G/A cg03342759 chr3:160939853 NMD3 -0.72 -18.03 -0.58 4.83e-59 Morning vs. evening chronotype; BRCA trans rs11098499 0.909 rs35111518 chr4:120440682 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.05 0.43 2.91e-30 Corneal astigmatism; BRCA cis rs6582630 0.519 rs9738104 chr12:38338459 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.02 0.37 4.91e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2425143 0.818 rs11167280 chr20:34560526 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -7.97 -0.3 7.08e-15 Blood protein levels; BRCA cis rs7666738 0.830 rs6830124 chr4:99054872 C/T cg05340658 chr4:99064831 C4orf37 -0.68 -17.22 -0.56 7.01e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs501916 0.554 rs10851460 chr15:48092994 A/G cg16110827 chr15:48056943 SEMA6D 0.38 8.04 0.3 4.3e-15 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs10504229 0.728 rs72650868 chr8:58155568 G/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs7100689 0.555 rs1934146 chr10:82062121 C/A cg00277334 chr10:82204260 NA -0.42 -8.23 -0.31 1.04e-15 Post bronchodilator FEV1; BRCA trans rs3780486 0.505 rs10217267 chr9:33146528 T/C cg20290983 chr6:43655470 MRPS18A 0.8 21.08 0.64 2.58e-75 IgG glycosylation; BRCA cis rs6840360 0.550 rs12651635 chr4:152557786 C/T cg22705602 chr4:152727874 NA -0.36 -8.84 -0.33 9.35e-18 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.882 rs17050660 chr3:10001772 A/G cg13047869 chr3:10149882 C3orf24 -0.52 -11.14 -0.4 1.83e-26 Alzheimer's disease; BRCA cis rs4332037 0.754 rs62436669 chr7:1926636 G/A cg23422044 chr7:1970798 MAD1L1 -0.71 -12.67 -0.45 5.67e-33 Bipolar disorder; BRCA cis rs3008870 0.816 rs1118392 chr1:67366549 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.75 -16.4 -0.54 1e-50 Lymphocyte percentage of white cells; BRCA cis rs9318086 0.648 rs35449605 chr13:24472582 G/A cg25267304 chr13:24462978 PCOTH;MIPEP 0.32 8.97 0.33 3.24e-18 Myopia (pathological); BRCA cis rs9420 0.961 rs7938083 chr11:57493622 C/A cg19752551 chr11:57585705 CTNND1 -0.48 -11.43 -0.41 1.17e-27 Schizophrenia; BRCA cis rs7647973 0.710 rs9869120 chr3:49624065 T/C cg03060546 chr3:49711283 APEH 0.6 9.83 0.36 2.5e-21 Menarche (age at onset); BRCA trans rs61931739 0.500 rs11052994 chr12:34065843 C/T cg26384229 chr12:38710491 ALG10B 0.68 14.12 0.49 1.32e-39 Morning vs. evening chronotype; BRCA cis rs2243480 1.000 rs6958420 chr7:65751171 A/G cg18252515 chr7:66147081 NA 1.04 15.68 0.53 4.14e-47 Diabetic kidney disease; BRCA cis rs6088580 0.634 rs6059896 chr20:33111783 T/C cg06115741 chr20:33292138 TP53INP2 0.35 7.89 0.3 1.29e-14 Glomerular filtration rate (creatinine); BRCA cis rs7267979 0.933 rs2258728 chr20:25276343 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.08e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7809950 0.817 rs62483725 chr7:107201575 G/A cg23024343 chr7:107201750 COG5 -0.48 -9.92 -0.37 1.1e-21 Coronary artery disease; BRCA trans rs208520 0.837 rs208488 chr6:66926902 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.36 -0.54 1.72e-50 Exhaled nitric oxide output; BRCA cis rs2594989 1.000 rs346081 chr3:11329085 A/G cg01796438 chr3:11312864 ATG7 -0.53 -8.38 -0.31 3.29e-16 Circulating chemerin levels; BRCA cis rs9868809 0.505 rs11706983 chr3:48738678 A/G cg01304814 chr3:48885189 PRKAR2A 0.57 7.97 0.3 7.2e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs6952808 0.564 rs73038441 chr7:2139286 T/C cg03354898 chr7:1950403 MAD1L1 -0.47 -9.56 -0.35 2.56e-20 Bipolar disorder and schizophrenia; BRCA cis rs853679 0.517 rs4713143 chr6:28106759 A/C cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.17 0.31 1.68e-15 Depression; BRCA cis rs1552244 0.938 rs7652951 chr3:10063763 A/C cg13047869 chr3:10149882 C3orf24 0.53 11.24 0.41 6.83e-27 Alzheimer's disease; BRCA cis rs698833 0.892 rs1067403 chr2:44675851 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 9.21 0.34 4.79e-19 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs6840360 0.533 rs4696297 chr4:152725838 T/G cg22705602 chr4:152727874 NA 0.39 10.37 0.38 2.19e-23 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.920 rs11511938 chr11:5928793 A/G cg02574844 chr11:5959923 NA -0.44 -8.6 -0.32 5.99e-17 DNA methylation (variation); BRCA cis rs2073300 1.000 rs6132622 chr20:23442240 A/T cg12062639 chr20:23401060 NAPB 0.87 10.46 0.38 9.93e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9443645 0.901 rs2050663 chr6:79753394 T/C cg05283184 chr6:79620031 NA -0.42 -10.63 -0.39 1.99e-24 Intelligence (multi-trait analysis); BRCA trans rs3780486 0.846 rs10738905 chr9:33123627 A/G cg04842962 chr6:43655489 MRPS18A 1.12 38.27 0.83 1.8e-167 IgG glycosylation; BRCA cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg22800045 chr5:56110881 MAP3K1 -0.47 -9.35 -0.35 1.47e-19 Initial pursuit acceleration; BRCA cis rs9486719 1.000 rs35487471 chr6:96879715 C/T cg06623918 chr6:96969491 KIAA0776 -0.73 -12.95 -0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs1008375 0.900 rs6851783 chr4:17578469 A/G cg16339924 chr4:17578868 LAP3 0.76 18.15 0.58 1.04e-59 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6942756 0.806 rs2694572 chr7:128911721 A/G cg02491457 chr7:128862824 NA 0.57 12.07 0.43 2.25e-30 White matter hyperintensity burden; BRCA cis rs9467773 0.525 rs1535274 chr6:26520747 A/C cg09904177 chr6:26538194 HMGN4 0.46 12.7 0.45 4.04e-33 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs12496634 chr3:52709259 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 3.02e-25 Bipolar disorder; BRCA cis rs9291683 0.509 rs998676 chr4:9948564 T/C cg00071950 chr4:10020882 SLC2A9 -0.53 -13.19 -0.46 2.49e-35 Bone mineral density; BRCA cis rs12618769 0.543 rs72819971 chr2:99034846 T/G cg10123293 chr2:99228465 UNC50 0.4 7.96 0.3 7.97e-15 Bipolar disorder; BRCA cis rs1577917 0.917 rs13196576 chr6:86534066 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.62 -0.42 1.85e-28 Response to antipsychotic treatment; BRCA cis rs6840360 0.571 rs4696110 chr4:152671325 G/A cg22705602 chr4:152727874 NA -0.37 -10.14 -0.37 1.7e-22 Intelligence (multi-trait analysis); BRCA cis rs2576037 0.526 rs998819 chr18:44564181 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -9.44 -0.35 6.71e-20 Personality dimensions; BRCA cis rs7267979 1.000 rs6107047 chr20:25442097 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.5 0.32 1.34e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2985684 0.894 rs10147029 chr14:50020232 G/T cg04989706 chr14:50066350 PPIL5 0.51 10.17 0.37 1.33e-22 Carotid intima media thickness; BRCA cis rs1552244 0.572 rs66514627 chr3:10166632 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 13.95 0.48 8.22e-39 Alzheimer's disease; BRCA cis rs7474896 0.616 rs2474561 chr10:38373544 C/T cg25427524 chr10:38739819 LOC399744 -0.6 -10.51 -0.38 6.1e-24 Obesity (extreme); BRCA cis rs2070488 0.736 rs2070988 chr3:38437835 C/T cg24069376 chr3:38537580 EXOG 0.31 8.2 0.31 1.28e-15 Electrocardiographic conduction measures; BRCA cis rs798554 0.757 rs1182178 chr7:2873763 G/A cg04166393 chr7:2884313 GNA12 0.48 9.17 0.34 6.17e-19 Height; BRCA cis rs870825 0.616 rs2141258 chr4:185609576 A/C cg04058563 chr4:185651563 MLF1IP -0.68 -13.29 -0.47 8.77e-36 Blood protein levels; BRCA cis rs7582180 0.663 rs2053263 chr2:100971407 A/G cg14675211 chr2:100938903 LONRF2 0.42 9.35 0.35 1.4e-19 Intelligence (multi-trait analysis); BRCA cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg23711669 chr6:146136114 FBXO30 -0.73 -15.41 -0.52 8.48e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs78456975 0.527 rs11885279 chr2:1560633 T/C cg12573674 chr2:1569213 NA -0.55 -11.95 -0.43 7.83e-30 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10504073 0.626 rs6472220 chr8:50008477 C/A cg00325661 chr8:49890786 NA 0.38 11.26 0.41 5.75e-27 Blood metabolite ratios; BRCA cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg20476274 chr7:133979776 SLC35B4 0.6 16.15 0.54 1.82e-49 Mean platelet volume; BRCA cis rs6570726 0.791 rs6912079 chr6:145894949 G/A cg05347473 chr6:146136440 FBXO30 0.42 8.4 0.32 2.93e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs12310956 0.532 rs1525897 chr12:33941033 C/T cg13010199 chr12:38710504 ALG10B 0.49 9.5 0.35 4.18e-20 Morning vs. evening chronotype; BRCA cis rs7811142 1.000 rs7803454 chr7:99991548 C/T cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.83 -12.42 -0.44 6.83e-32 Platelet count; BRCA trans rs9858213 1 rs9858213 chr3:49731861 G/T cg21659725 chr3:3221576 CRBN -0.46 -9.58 -0.35 2.13e-20 Educational attainment; BRCA cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg12927641 chr6:109611667 NA -0.4 -10.39 -0.38 1.75e-23 Reticulocyte fraction of red cells; BRCA cis rs9443645 0.869 rs7756858 chr6:79619968 A/G cg18132916 chr6:79620363 NA -0.45 -10.17 -0.37 1.24e-22 Intelligence (multi-trait analysis); BRCA cis rs763121 0.853 rs1043441 chr22:39130964 C/T cg06022373 chr22:39101656 GTPBP1 0.74 17.05 0.56 5.08e-54 Menopause (age at onset); BRCA cis rs367943 0.698 rs10046061 chr5:112976533 A/G cg12552261 chr5:112820674 MCC 0.37 7.87 0.3 1.5e-14 Type 2 diabetes; BRCA cis rs7666738 0.830 rs13129503 chr4:98987892 T/C cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.798 rs4324365 chr2:99623845 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs2625529 0.824 rs16956328 chr15:72143855 A/T cg16672083 chr15:72433130 SENP8 -0.83 -17.22 -0.56 7.53e-55 Red blood cell count; BRCA cis rs6460942 1.000 rs17274870 chr7:12406221 G/T cg20607287 chr7:12443886 VWDE -0.57 -8.03 -0.3 4.69e-15 Coronary artery disease; BRCA cis rs4665809 0.878 rs35709953 chr2:26334997 G/A cg22920501 chr2:26401640 FAM59B 0.76 10.92 0.4 1.44e-25 Gut microbiome composition (summer); BRCA cis rs600806 0.888 rs3879450 chr1:109909149 C/T cg20591472 chr1:110008990 SYPL2 0.32 8.06 0.3 3.71e-15 Intelligence (multi-trait analysis); BRCA cis rs7580658 0.545 rs13006847 chr2:127952263 C/T cg16751203 chr2:127950803 CYP27C1 -0.28 -8.27 -0.31 7.95e-16 Protein C levels; BRCA cis rs7662987 0.517 rs2602878 chr4:100039953 T/G cg12011299 chr4:100065546 ADH4 0.48 10.8 0.39 4.39e-25 Smoking initiation; BRCA cis rs875971 0.964 rs55748098 chr7:65763618 T/C cg11764359 chr7:65958608 NA -0.8 -19.57 -0.61 3.39e-67 Aortic root size; BRCA trans rs6598955 0.585 rs6659822 chr1:26626408 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.65 -15.56 -0.52 1.65e-46 Obesity-related traits; BRCA cis rs6446731 0.593 rs6446728 chr4:3275650 A/G cg08886695 chr4:3369023 RGS12 -0.38 -9.92 -0.37 1.1e-21 Mean platelet volume; BRCA cis rs4588572 0.644 rs10805920 chr5:77698222 G/A cg11547950 chr5:77652471 NA -0.43 -8.36 -0.31 4.01e-16 Triglycerides; BRCA cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg18132916 chr6:79620363 NA -0.38 -7.82 -0.3 2.2e-14 Intelligence (multi-trait analysis); BRCA cis rs1865721 0.771 rs6566093 chr18:73136682 T/C cg26385618 chr18:73139727 C18orf62 -0.43 -10.64 -0.39 1.88e-24 Intelligence; BRCA cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs6831352 0.918 rs4699714 chr4:100060538 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.64 -0.36 1.27e-20 Alcohol dependence; BRCA cis rs2463822 1.000 rs1881534 chr11:62085083 A/G cg06239285 chr11:62104954 ASRGL1 0.61 8.89 0.33 6.39e-18 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs35306767 0.903 rs61833260 chr10:975148 T/G cg10556349 chr10:835070 NA 0.67 9.67 0.36 9.78e-21 Eosinophil percentage of granulocytes; BRCA cis rs2303745 0.622 rs1864113 chr19:17393504 G/C cg02221750 chr19:17393354 ANKLE1 -0.65 -12.55 -0.44 1.92e-32 Systemic lupus erythematosus; BRCA cis rs6951245 0.507 rs11976805 chr7:1138716 C/T cg26224354 chr7:1096374 C7orf50;GPR146 -0.54 -10.85 -0.39 2.73e-25 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs477692 0.625 rs4751104 chr10:131405358 G/A cg05714579 chr10:131428358 MGMT -0.71 -17.98 -0.58 8.32e-59 Response to temozolomide; BRCA cis rs9463078 0.874 rs2093903 chr6:45177482 A/C cg25276700 chr6:44698697 NA -0.36 -8.02 -0.3 5.18e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg05564831 chr3:52568323 NT5DC2 0.34 8.08 0.3 3.32e-15 Electroencephalogram traits; BRCA cis rs12530845 0.830 rs73721678 chr7:135355710 T/G cg23117316 chr7:135346802 PL-5283 -0.41 -9.5 -0.35 3.99e-20 Red blood cell traits; BRCA cis rs12612619 0.732 rs12616092 chr2:27217228 G/A cg00617064 chr2:27272375 NA -0.32 -8.51 -0.32 1.25e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs4434138 0.594 rs7653028 chr3:52763000 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.83 -0.3 1.98e-14 Intelligence (multi-trait analysis); BRCA cis rs9372253 0.934 rs9320327 chr6:110715194 T/A cg01119278 chr6:110721349 DDO -0.43 -10.46 -0.38 9.28e-24 Platelet distribution width; BRCA cis rs7666738 0.830 rs17484966 chr4:99014432 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7814319 0.899 rs1878638 chr8:97258719 C/T cg20787634 chr8:97240163 UQCRB -0.51 -11.83 -0.42 2.4e-29 Lung function (FVC); BRCA trans rs208520 0.690 rs207114 chr6:66791703 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.76 -0.63 1.55e-73 Exhaled nitric oxide output; BRCA cis rs1552244 0.572 rs7645759 chr3:10157368 C/T cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.46 -0.35 5.87e-20 Alzheimer's disease; BRCA trans rs66887589 0.616 rs11098498 chr4:120187119 T/C cg25214090 chr10:38739885 LOC399744 0.38 8.73 0.33 2.24e-17 Diastolic blood pressure; BRCA cis rs35306767 0.953 rs10904583 chr10:983498 T/C cg26597838 chr10:835615 NA 0.8 14.26 0.49 3.06e-40 Eosinophil percentage of granulocytes; BRCA trans rs61931739 0.500 rs11053203 chr12:34456593 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.51 0.35 3.82e-20 Morning vs. evening chronotype; BRCA cis rs2346177 0.875 rs4413204 chr2:46647092 C/G cg02822958 chr2:46747628 ATP6V1E2 0.38 7.85 0.3 1.72e-14 HDL cholesterol; BRCA cis rs56399783 0.808 rs73049331 chr7:2799911 C/T cg19731401 chr7:2775893 GNA12 0.49 7.9 0.3 1.23e-14 Childhood ear infection; BRCA cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg04586622 chr2:25135609 ADCY3 0.43 10.68 0.39 1.29e-24 Body mass index; BRCA cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg25427524 chr10:38739819 LOC399744 -0.65 -15.66 -0.53 5.1e-47 Extrinsic epigenetic age acceleration; BRCA cis rs344364 0.511 rs62040569 chr16:1948137 C/T cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg18404041 chr3:52824283 ITIH1 -0.38 -11.52 -0.41 5.06e-28 Electroencephalogram traits; BRCA cis rs953387 1.000 rs4954392 chr2:136901607 A/G cg05194412 chr2:137003533 NA -0.37 -8.39 -0.32 3.07e-16 Arthritis (juvenile idiopathic); BRCA cis rs2839186 0.739 rs2280958 chr21:47642016 C/T cg13732083 chr21:47605072 C21orf56 0.39 7.98 0.3 6.74e-15 Testicular germ cell tumor; BRCA cis rs9733 0.519 rs1336899 chr1:150678910 T/C cg17724175 chr1:150552817 MCL1 0.25 8.42 0.32 2.44e-16 Tonsillectomy; BRCA cis rs1862618 0.671 rs2591970 chr5:56232595 T/C cg18230493 chr5:56204884 C5orf35 0.62 13.27 0.46 1.14e-35 Initial pursuit acceleration; BRCA cis rs2836974 0.897 rs2836923 chr21:40524236 T/C cg11644478 chr21:40555479 PSMG1 0.82 18.57 0.59 7.21e-62 Cognitive function; BRCA cis rs9814567 1.000 rs9813774 chr3:134227100 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.67 -0.61 9.89e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg24562669 chr7:97807699 LMTK2 -0.52 -13.1 -0.46 6.61e-35 Prostate cancer (SNP x SNP interaction); BRCA cis rs7551345 0.803 rs7513300 chr1:31698466 C/T cg19084893 chr1:31688959 NA -0.46 -10.04 -0.37 4.13e-22 Schizophrenia; BRCA cis rs1577917 0.958 rs2660576 chr6:86651603 T/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.39 -0.41 1.76e-27 Response to antipsychotic treatment; BRCA cis rs7582180 0.629 rs11686842 chr2:100956139 C/T cg08017756 chr2:100939284 LONRF2 -0.3 -7.91 -0.3 1.18e-14 Intelligence (multi-trait analysis); BRCA cis rs1552244 0.572 rs3894321 chr3:10168892 A/C cg00149659 chr3:10157352 C3orf10 1.03 17.8 0.58 7.26e-58 Alzheimer's disease; BRCA trans rs11088226 0.801 rs2833886 chr21:33923872 C/A cg09050820 chr6:167586206 TCP10L2 0.57 10.8 0.39 4.2e-25 Gastritis; BRCA cis rs17711722 0.528 rs73138179 chr7:65294482 G/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.65 13.98 0.48 6.35e-39 Calcium levels; BRCA cis rs6831352 0.840 rs17817868 chr4:100060623 C/T cg12011299 chr4:100065546 ADH4 -0.51 -11.76 -0.42 5.05e-29 Alcohol dependence; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.74 16.0 0.53 9.97e-49 Lymphocyte counts; BRCA cis rs11971779 0.715 rs6943973 chr7:139029893 G/C cg07862535 chr7:139043722 LUC7L2 0.39 10.46 0.38 9.65e-24 Diisocyanate-induced asthma; BRCA trans rs7819412 0.522 rs3021495 chr8:10994743 C/G cg15556689 chr8:8085844 FLJ10661 -0.34 -7.88 -0.3 1.45e-14 Triglycerides; BRCA cis rs12477438 0.520 rs1133978 chr2:99741964 C/T cg08885076 chr2:99613938 TSGA10 0.42 9.73 0.36 5.81e-21 Chronic sinus infection; BRCA cis rs4887140 1.000 rs4887140 chr15:74046663 G/T cg11789681 chr15:74046708 NA 0.55 9.03 0.34 2.07e-18 Glucose homeostasis traits; BRCA cis rs4240897 0.935 rs1474868 chr1:12044164 A/G cg13216073 chr1:12042593 MFN2 -0.55 -13.38 -0.47 3.71e-36 Tuberculosis; BRCA cis rs10927875 0.518 rs1763597 chr1:16343297 C/T cg22431228 chr1:16359049 CLCNKA -0.44 -9.82 -0.36 2.75e-21 Dilated cardiomyopathy; BRCA cis rs4481887 0.800 rs10788780 chr1:248483598 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.59 0.32 6.48e-17 Common traits (Other); BRCA cis rs7666738 0.830 rs9996098 chr4:98867740 T/C cg17366294 chr4:99064904 C4orf37 0.42 9.78 0.36 3.87e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg12444411 chr7:2802554 GNA12 -0.36 -8.96 -0.33 3.52e-18 Height; BRCA cis rs875971 0.862 rs778707 chr7:65857027 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.37 7.82 0.3 2.21e-14 Aortic root size; BRCA cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs2303759 0.709 rs3760667 chr19:49814832 C/T cg24324837 chr19:49891574 CCDC155 0.47 7.94 0.3 9.35e-15 Multiple sclerosis; BRCA cis rs13382862 0.895 rs2289082 chr2:20881958 A/T cg10553204 chr2:20871195 GDF7 0.28 7.92 0.3 1.05e-14 Abdominal aortic aneurysm; BRCA cis rs701145 0.585 rs1713853 chr3:153795595 A/G cg17054900 chr3:154042577 DHX36 0.54 9.14 0.34 8.17e-19 Coronary artery disease; BRCA cis rs1448094 0.512 rs11503595 chr12:86244075 T/A cg19622623 chr12:86230825 RASSF9 -0.33 -9.35 -0.35 1.47e-19 Major depressive disorder; BRCA cis rs921968 0.541 rs17572485 chr2:219296545 C/T cg02176678 chr2:219576539 TTLL4 -0.44 -11.63 -0.42 1.7e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs883565 1.000 rs883565 chr3:39055317 C/T cg26331595 chr3:39149181 GORASP1;TTC21A 0.38 7.81 0.3 2.42e-14 Handedness; BRCA cis rs11249608 0.636 rs6868893 chr5:178449826 C/A cg21905437 chr5:178450457 ZNF879 0.52 10.65 0.39 1.7e-24 Pubertal anthropometrics; BRCA trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg15704280 chr7:45808275 SEPT13 0.84 18.84 0.6 2.54e-63 Height; BRCA cis rs6831352 0.877 rs28987101 chr4:100049253 T/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs3733585 0.674 rs7375643 chr4:9955239 A/G cg00071950 chr4:10020882 SLC2A9 -0.54 -13.5 -0.47 1.05e-36 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg11707556 chr5:10655725 ANKRD33B 0.44 9.75 0.36 5.06e-21 Coronary artery disease; BRCA cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg23018236 chr17:30244563 NA -0.71 -11.07 -0.4 3.42e-26 Hip circumference adjusted for BMI; BRCA cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg16339924 chr4:17578868 LAP3 0.58 14.13 0.49 1.17e-39 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 1.000 rs17032277 chr3:10077023 T/C cg16606324 chr3:10149918 C3orf24 0.55 10.84 0.39 2.97e-25 Alzheimer's disease; BRCA cis rs9457247 0.715 rs6923582 chr6:167437162 T/A cg07741184 chr6:167504864 NA 0.28 8.19 0.31 1.44e-15 Crohn's disease; BRCA cis rs67478160 0.679 rs7156834 chr14:104211180 G/A cg26031613 chr14:104095156 KLC1 -0.45 -8.75 -0.33 1.94e-17 Schizophrenia; BRCA cis rs13191362 0.938 rs28360532 chr6:162997477 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.36 0.44 1.23e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs72781680 1.000 rs72788280 chr2:24095907 A/G cg20701182 chr2:24300061 SF3B14 0.57 8.93 0.33 4.55e-18 Lymphocyte counts; BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.18 0.34 6.13e-19 Tonsillectomy; BRCA cis rs801193 1.000 rs2055682 chr7:66260289 A/G cg18876405 chr7:65276391 NA 0.62 15.02 0.51 6.87e-44 Aortic root size; BRCA cis rs17641971 0.662 rs2385229 chr8:50003869 T/C cg00325661 chr8:49890786 NA 0.35 10.1 0.37 2.38e-22 Blood metabolite levels; BRCA cis rs2153535 0.580 rs718503 chr6:8527463 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.45 0.38 1.08e-23 Motion sickness; BRCA cis rs1707322 1.000 rs4660903 chr1:46457601 A/G cg06784218 chr1:46089804 CCDC17 0.45 10.85 0.39 2.66e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs459571 0.629 rs441233 chr9:136876021 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.87 17.77 0.58 9.98e-58 Platelet distribution width; BRCA cis rs2019137 0.560 rs6707386 chr2:113981022 G/A cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.59 12.53 0.44 2.3e-32 Lymphocyte counts; BRCA cis rs8180040 0.932 rs62246474 chr3:47398130 C/T cg16586182 chr3:47516702 SCAP 0.62 14.4 0.49 6.48e-41 Colorectal cancer; BRCA cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg12573674 chr2:1569213 NA -0.43 -8.12 -0.31 2.37e-15 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs769267 0.899 rs67720221 chr19:19440864 C/T cg17414380 chr19:19431394 KIAA0892;SF4 -0.46 -9.55 -0.35 2.62e-20 Tonsillectomy; BRCA cis rs12579753 0.917 rs76240969 chr12:82195236 C/A cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.93e-17 Resting heart rate; BRCA cis rs11105298 0.891 rs6538190 chr12:89885942 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.97 -0.37 7.48e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6121246 0.559 rs6121038 chr20:30254773 T/G cg13852791 chr20:30311386 BCL2L1 0.94 22.77 0.67 1.79e-84 Mean corpuscular hemoglobin; BRCA cis rs490234 0.812 rs12351825 chr9:128265736 T/C cg14078157 chr9:128172775 NA -0.48 -10.96 -0.4 1.03e-25 Mean arterial pressure; BRCA cis rs1129187 0.720 rs9471972 chr6:42915021 G/A cg13397359 chr6:42928475 GNMT 0.63 14.24 0.49 3.48e-40 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs739401 0.572 rs739399 chr11:3016452 A/G cg08508325 chr11:3079039 CARS -0.4 -14.23 -0.49 3.97e-40 Longevity; BRCA cis rs1707322 0.896 rs809774 chr1:46560244 T/A cg03146154 chr1:46216737 IPP -0.44 -9.49 -0.35 4.59e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2108225 0.872 rs4618632 chr7:107440952 T/G cg18560240 chr7:107437656 SLC26A3 -0.54 -11.23 -0.41 7.92e-27 Ulcerative colitis; BRCA cis rs9814567 1.000 rs7645295 chr3:134307734 T/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.5 -0.61 8.18e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12134245 0.776 rs625525 chr1:91997593 C/T cg02896835 chr1:92012615 NA -0.6 -15.79 -0.53 1.11e-47 Breast cancer; BRCA cis rs875971 0.862 rs908915 chr7:65614651 G/T cg18876405 chr7:65276391 NA -0.51 -11.74 -0.42 5.96e-29 Aortic root size; BRCA cis rs10193935 0.901 rs222464 chr2:42643889 C/T cg27598129 chr2:42591480 NA -0.88 -14.36 -0.49 9.66e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs7191439 0.858 rs11076702 chr16:88774569 A/C cg27087555 chr16:88793112 FAM38A -1.3 -16.55 -0.55 1.93e-51 Plateletcrit; BRCA cis rs4555082 0.830 rs2735812 chr14:105727575 A/G cg10792982 chr14:105748885 BRF1 0.49 11.29 0.41 4.54e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs763014 0.932 rs2384975 chr16:651115 G/T cg09256448 chr16:638327 NA 0.31 8.51 0.32 1.27e-16 Height; BRCA cis rs7103648 0.808 rs7103835 chr11:47461693 G/A cg03711944 chr11:47377212 SPI1 -0.42 -10.08 -0.37 2.79e-22 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs9649213 0.593 rs35941058 chr7:97918159 T/C cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.73e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6545883 0.895 rs2177961 chr2:61560264 T/C cg15711740 chr2:61764176 XPO1 0.53 13.45 0.47 1.7e-36 Tuberculosis; BRCA cis rs11098499 0.954 rs2892848 chr4:120381341 C/T cg09307838 chr4:120376055 NA 0.75 16.18 0.54 1.37e-49 Corneal astigmatism; BRCA cis rs1865760 0.541 rs1436309 chr6:25970109 T/A cg17691542 chr6:26056736 HIST1H1C 0.5 10.38 0.38 1.89e-23 Height; BRCA cis rs2075671 0.903 rs62483570 chr7:100300649 C/T cg20848291 chr7:100343083 ZAN -0.62 -13.01 -0.46 1.76e-34 Other erythrocyte phenotypes; BRCA cis rs2153535 0.560 rs9379214 chr6:8480870 T/C cg21535247 chr6:8435926 SLC35B3 0.42 9.5 0.35 4.14e-20 Motion sickness; BRCA cis rs7586879 0.616 rs6545814 chr2:25131316 A/G cg04586622 chr2:25135609 ADCY3 0.46 11.49 0.41 6.43e-28 Body mass index; BRCA cis rs858239 0.601 rs10278776 chr7:23169759 C/T cg23682824 chr7:23144976 KLHL7 0.45 11.96 0.43 7.05e-30 Cerebrospinal fluid biomarker levels; BRCA cis rs8103278 1.000 rs8109951 chr19:46289503 C/T cg12641515 chr19:46296257 DMWD -0.57 -12.56 -0.44 1.73e-32 Coronary artery disease; BRCA cis rs1971762 0.563 rs11170645 chr12:54079080 G/T cg23533419 chr12:54090519 NA -0.32 -8.11 -0.31 2.62e-15 Height; BRCA cis rs9325144 0.581 rs2653758 chr12:38946233 G/T cg13010199 chr12:38710504 ALG10B -0.35 -7.93 -0.3 9.69e-15 Morning vs. evening chronotype; BRCA cis rs13191362 0.935 rs35942036 chr6:163163297 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.02 14.89 0.51 2.87e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7824557 0.767 rs1897950 chr8:11169551 C/A cg06636001 chr8:8085503 FLJ10661 0.54 10.08 0.37 2.73e-22 Retinal vascular caliber; BRCA cis rs769267 0.931 rs15622 chr19:19468734 G/A cg20644253 chr19:19431407 KIAA0892;SF4 -0.61 -12.26 -0.44 3.51e-31 Tonsillectomy; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.17 -0.34 6.4e-19 Total body bone mineral density; BRCA cis rs68170813 0.559 rs10953532 chr7:106881808 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.44 -0.32 2.13e-16 Coronary artery disease; BRCA cis rs1008375 1.000 rs10027755 chr4:17615954 G/C cg04450456 chr4:17643702 FAM184B 0.36 10.47 0.38 8.41e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9487051 0.768 rs9398188 chr6:109526615 G/A cg21918786 chr6:109611834 NA -0.34 -8.97 -0.33 3.22e-18 Reticulocyte fraction of red cells; BRCA cis rs1008375 0.932 rs6449321 chr4:17644472 A/G cg15017067 chr4:17643749 FAM184B 0.29 9.01 0.34 2.29e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs13095912 0.889 rs34765114 chr3:185335156 T/A cg11274856 chr3:185301563 NA 0.36 9.01 0.34 2.32e-18 Systolic blood pressure; BRCA cis rs9790314 1.000 rs336567 chr3:161073046 A/G cg03342759 chr3:160939853 NMD3 -0.63 -13.45 -0.47 1.65e-36 Morning vs. evening chronotype; BRCA cis rs7246657 0.943 rs28402338 chr19:37833923 G/A cg23950597 chr19:37808831 NA -0.72 -12.58 -0.45 1.42e-32 Coronary artery calcification; BRCA cis rs8103278 1.000 rs17571725 chr19:46290822 C/T cg12641515 chr19:46296257 DMWD -0.56 -12.52 -0.44 2.54e-32 Coronary artery disease; BRCA cis rs12479064 0.724 rs6748200 chr2:100080895 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.54 -11.43 -0.41 1.2e-27 Chronic sinus infection; BRCA cis rs7520050 0.966 rs7522601 chr1:46419021 G/A cg24296786 chr1:45957014 TESK2 0.44 9.76 0.36 4.47e-21 Red blood cell count;Reticulocyte count; BRCA cis rs9309473 0.607 rs6716776 chr2:73587713 T/C cg20560298 chr2:73613845 ALMS1 -0.47 -12.64 -0.45 7.83e-33 Metabolite levels; BRCA cis rs4853036 0.904 rs2278934 chr2:70121197 T/C cg02498382 chr2:70120550 SNRNP27 -0.54 -10.72 -0.39 8.68e-25 Colorectal or endometrial cancer; BRCA cis rs6598955 0.543 rs112752634 chr1:26534217 G/A cg12744634 chr1:26560303 CCDC21 0.32 8.64 0.32 4.46e-17 Obesity-related traits; BRCA cis rs11690935 0.959 rs12185567 chr2:172560729 A/C cg13550731 chr2:172543902 DYNC1I2 0.93 30.86 0.77 9.53e-129 Schizophrenia; BRCA cis rs2576037 0.526 rs571181 chr18:44376399 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.48 10.49 0.38 7.14e-24 Personality dimensions; BRCA cis rs9875589 0.509 rs1601868 chr3:14065450 T/C cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.97 0.33 3.39e-18 Ovarian reserve; BRCA cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs208520 0.874 rs208512 chr6:66943869 C/G cg07460842 chr6:66804631 NA -0.82 -14.66 -0.5 3.52e-42 Exhaled nitric oxide output; BRCA trans rs853679 0.882 rs9461432 chr6:28086883 T/C cg01620082 chr3:125678407 NA -0.57 -8.08 -0.3 3.19e-15 Depression; BRCA cis rs875971 0.522 rs10807697 chr7:65416170 A/G cg18876405 chr7:65276391 NA 0.7 18.55 0.59 9.27e-62 Aortic root size; BRCA cis rs6089584 0.888 rs6061981 chr20:60618973 T/C cg13770153 chr20:60521292 NA -0.43 -9.51 -0.35 3.76e-20 Body mass index; BRCA cis rs1065852 0.526 rs59993856 chr22:42403980 C/T cg22189786 chr22:42395067 WBP2NL 0.43 8.75 0.33 1.91e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs10751667 0.643 rs11246348 chr11:939476 G/C cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.42e-34 Alzheimer's disease (late onset); BRCA cis rs2243480 0.901 rs73148097 chr7:65431787 A/C cg18252515 chr7:66147081 NA -0.9 -12.92 -0.46 4.23e-34 Diabetic kidney disease; BRCA cis rs10789491 1.000 rs4553120 chr1:47165729 C/T cg15501359 chr1:47185051 KIAA0494 0.66 18.42 0.59 4.08e-61 Response to hepatitis C treatment; BRCA trans rs561341 1.000 rs484175 chr17:30309041 G/A cg27661571 chr11:113659931 NA -0.7 -10.89 -0.4 1.93e-25 Hip circumference adjusted for BMI; BRCA cis rs12950390 0.853 rs4793647 chr17:45854090 G/C cg24803719 chr17:45855879 NA -0.31 -8.1 -0.31 2.77e-15 IgG glycosylation; BRCA cis rs1348850 0.914 rs4893957 chr2:178380409 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.47 9.55 0.35 2.68e-20 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8062405 0.755 rs17707300 chr16:28593347 A/G cg16576597 chr16:28551801 NUPR1 0.31 8.48 0.32 1.51e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs11191270 1.000 rs11191270 chr10:104124605 C/T cg15320455 chr10:103880129 LDB1 0.5 8.18 0.31 1.5e-15 Intelligence (multi-trait analysis); BRCA cis rs68170813 0.599 rs6466162 chr7:106902625 C/T cg02696742 chr7:106810147 HBP1 -0.52 -8.97 -0.33 3.36e-18 Coronary artery disease; BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg05863683 chr7:1912471 MAD1L1 0.38 8.23 0.31 1.02e-15 Bipolar disorder and schizophrenia; BRCA cis rs10504229 0.728 rs17215851 chr8:58154160 A/C cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.508 rs10253883 chr7:66061138 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.41 -8.96 -0.33 3.47e-18 Aortic root size; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg27170947 chr2:26402098 FAM59B 0.98 17.25 0.56 4.73e-55 Gut microbiome composition (summer); BRCA cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.76 -0.57 1.24e-57 Chronic sinus infection; BRCA cis rs796364 0.951 rs10931888 chr2:201022952 T/G cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.86 -0.39 2.43e-25 Schizophrenia; BRCA cis rs61931739 0.517 rs11513519 chr12:34075077 G/A cg06521331 chr12:34319734 NA -0.62 -11.16 -0.4 1.52e-26 Morning vs. evening chronotype; BRCA cis rs8114671 0.562 rs2889861 chr20:33405664 C/T cg07148914 chr20:33460835 GGT7 0.36 8.01 0.3 5.34e-15 Height; BRCA cis rs4566357 0.615 rs4675139 chr2:227908527 G/A cg05526886 chr2:227700861 RHBDD1 -0.38 -7.99 -0.3 6.19e-15 Coronary artery disease; BRCA cis rs6952808 0.609 rs6950151 chr7:1953521 T/C cg03354898 chr7:1950403 MAD1L1 -0.59 -14.23 -0.49 3.9e-40 Bipolar disorder and schizophrenia; BRCA cis rs7011049 1.000 rs4521776 chr8:53838833 G/C cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs6088580 0.543 rs4911158 chr20:33239512 T/C cg08999081 chr20:33150536 PIGU -0.33 -8.48 -0.32 1.56e-16 Glomerular filtration rate (creatinine); BRCA cis rs2625529 0.627 rs12898585 chr15:72473928 T/C cg16672083 chr15:72433130 SENP8 -0.75 -16.05 -0.54 6.09e-49 Red blood cell count; BRCA cis rs7829975 0.582 rs6983150 chr8:8792426 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -8.98 -0.33 3.09e-18 Mood instability; BRCA cis rs898097 0.585 rs9892342 chr17:80893029 C/T cg15664640 chr17:80829946 TBCD 0.4 10.74 0.39 7.73e-25 Breast cancer; BRCA trans rs11039798 0.588 rs7946443 chr11:48545504 G/A cg03929089 chr4:120376271 NA 0.49 8.21 0.31 1.24e-15 Axial length; BRCA cis rs1008375 1.000 rs7661631 chr4:17679751 T/C cg04450456 chr4:17643702 FAM184B -0.34 -10.01 -0.37 5.44e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9815354 0.812 rs17218103 chr3:41943724 A/G cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs6089584 0.888 rs6061966 chr20:60607936 C/G cg06108461 chr20:60628389 TAF4 -0.99 -21.98 -0.66 3.68e-80 Body mass index; BRCA cis rs66887589 0.934 rs56843000 chr4:120516597 T/C cg09307838 chr4:120376055 NA -0.44 -9.18 -0.34 5.72e-19 Diastolic blood pressure; BRCA cis rs703842 1.000 rs11172333 chr12:58170335 A/G cg00677455 chr12:58241039 CTDSP2 0.62 13.95 0.48 8.34e-39 Multiple sclerosis; BRCA cis rs4363385 0.747 rs1415971 chr1:152965779 T/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.44 -0.35 7.12e-20 Inflammatory skin disease; BRCA cis rs7647973 0.667 rs11721148 chr3:49646669 G/A cg06212747 chr3:49208901 KLHDC8B 0.51 8.0 0.3 5.96e-15 Menarche (age at onset); BRCA cis rs6545883 0.718 rs2694624 chr2:61672313 C/A cg15711740 chr2:61764176 XPO1 -0.53 -13.52 -0.47 8.07e-37 Tuberculosis; BRCA cis rs7481584 0.624 rs1077335 chr11:3030524 A/G cg08508325 chr11:3079039 CARS 0.27 7.89 0.3 1.3e-14 Calcium levels; BRCA cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg08885076 chr2:99613938 TSGA10 0.45 10.61 0.39 2.51e-24 Chronic sinus infection; BRCA cis rs67478160 0.595 rs2295146 chr14:104199356 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -11.55 -0.42 3.66e-28 Schizophrenia; BRCA cis rs7772486 0.846 rs9373482 chr6:146363123 A/C cg13319975 chr6:146136371 FBXO30 -0.37 -8.56 -0.32 8.41e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs801193 1.000 rs11773829 chr7:66141074 G/A cg18876405 chr7:65276391 NA -0.63 -15.57 -0.52 1.36e-46 Aortic root size; BRCA cis rs847851 0.630 rs9462021 chr6:34758640 C/T cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.42e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8058578 1.000 rs7204278 chr16:30730274 A/G cg02466173 chr16:30829666 NA -0.55 -11.65 -0.42 1.43e-28 Multiple myeloma; BRCA cis rs6964587 1.000 rs10245095 chr7:91710845 A/G cg17063962 chr7:91808500 NA 0.58 13.58 0.47 4.22e-37 Breast cancer; BRCA cis rs2645694 0.911 rs2703147 chr4:77831307 C/T cg10057126 chr4:77819792 ANKRD56 0.58 12.78 0.45 1.79e-33 Emphysema distribution in smoking; BRCA cis rs812925 0.519 rs2922089 chr2:61625129 T/G cg15711740 chr2:61764176 XPO1 0.33 8.1 0.31 2.86e-15 Immature fraction of reticulocytes; BRCA cis rs6840360 0.615 rs7669761 chr4:152609304 G/A cg22705602 chr4:152727874 NA -0.37 -10.08 -0.37 2.9e-22 Intelligence (multi-trait analysis); BRCA cis rs7631605 0.905 rs9869432 chr3:37196601 A/G cg15934958 chr3:37212084 LRRFIP2 0.39 8.82 0.33 1.11e-17 Cerebrospinal P-tau181p levels; BRCA cis rs1862618 0.802 rs33327 chr5:56142693 T/G cg12311346 chr5:56204834 C5orf35 -0.81 -16.05 -0.54 5.76e-49 Initial pursuit acceleration; BRCA trans rs9951602 0.541 rs7243702 chr18:76645637 G/A cg02800362 chr5:177631904 HNRNPAB 0.77 17.67 0.57 3.29e-57 Obesity-related traits; BRCA cis rs798554 0.723 rs798518 chr7:2777825 A/G cg13628971 chr7:2884303 GNA12 0.47 9.82 0.36 2.8e-21 Height; BRCA cis rs34779708 0.931 rs7099593 chr10:35366878 A/C cg03585969 chr10:35415529 CREM 0.48 10.22 0.37 8.56e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs11249608 0.548 rs10479519 chr5:178450693 T/C cg21905437 chr5:178450457 ZNF879 0.53 11.12 0.4 2.22e-26 Pubertal anthropometrics; BRCA cis rs10504229 1.000 rs60454728 chr8:58173781 G/A cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs6831352 0.918 rs7689753 chr4:100055575 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA trans rs11098499 0.954 rs66506550 chr4:120371445 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA cis rs2153535 0.580 rs9406158 chr6:8464152 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs9467773 0.595 rs7767847 chr6:26597893 A/T cg11502198 chr6:26597334 ABT1 0.58 12.64 0.45 7.69e-33 Intelligence (multi-trait analysis); BRCA cis rs7618501 0.633 rs12485600 chr3:50025530 A/G cg05623727 chr3:50126028 RBM5 0.42 10.02 0.37 4.59e-22 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs6546744 chr2:26302161 A/G cg25036284 chr2:26402008 FAM59B -0.66 -10.91 -0.4 1.6e-25 Gut microbiome composition (summer); BRCA cis rs7258465 0.931 rs7249020 chr19:18608147 A/G cg01065977 chr19:18549689 ISYNA1 -0.28 -8.3 -0.31 6.14e-16 Breast cancer; BRCA cis rs4665809 0.590 rs10179959 chr2:26426403 G/A cg22920501 chr2:26401640 FAM59B -0.91 -16.48 -0.55 3.91e-51 Gut microbiome composition (summer); BRCA cis rs919433 1.000 rs1429414 chr2:198162430 C/T cg10820045 chr2:198174542 NA -0.39 -9.07 -0.34 1.42e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs921968 0.643 rs500317 chr2:219432953 G/C cg02176678 chr2:219576539 TTLL4 0.4 10.88 0.4 2.13e-25 Mean corpuscular hemoglobin concentration; BRCA cis rs12586317 0.547 rs10142667 chr14:35445090 A/G cg16230307 chr14:35515116 FAM177A1 0.73 15.18 0.51 1.16e-44 Psoriasis; BRCA cis rs9814567 1.000 rs6800862 chr3:134228628 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.57 -0.61 3.58e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs910316 1.000 rs175426 chr14:75624134 C/T cg08847533 chr14:75593920 NEK9 -0.87 -21.97 -0.66 3.87e-80 Height; BRCA cis rs2153535 0.580 rs2225766 chr6:8481833 G/A cg21535247 chr6:8435926 SLC35B3 0.38 8.74 0.33 2.11e-17 Motion sickness; BRCA cis rs7662987 0.517 rs1453873 chr4:100022571 T/C cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Smoking initiation; BRCA cis rs1552244 0.816 rs17050701 chr3:10041554 A/G cg00166722 chr3:10149974 C3orf24 0.55 10.74 0.39 7.48e-25 Alzheimer's disease; BRCA cis rs9649213 0.593 rs3779194 chr7:98010277 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.61 -0.32 5.8e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7666738 0.962 rs1527515 chr4:99025733 C/A cg17366294 chr4:99064904 C4orf37 0.53 11.22 0.41 8.92e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.54 -0.32 9.81e-17 Electroencephalogram traits; BRCA cis rs2836974 0.666 rs2836975 chr21:40663620 A/G cg11890956 chr21:40555474 PSMG1 -0.83 -21.15 -0.64 1.19e-75 Cognitive function; BRCA cis rs6815814 0.950 rs55830619 chr4:38807364 G/A cg06935464 chr4:38784597 TLR10 0.5 8.36 0.31 4.02e-16 Breast cancer; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.59 -11.17 -0.4 1.39e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2842992 0.789 rs3818300 chr6:160201677 G/A cg11366901 chr6:160182831 ACAT2 0.83 16.28 0.54 4.3e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs881375 0.678 rs7021049 chr9:123683982 G/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.54 11.64 0.42 1.51e-28 Rheumatoid arthritis; BRCA cis rs7618915 0.547 rs12486847 chr3:52691112 T/C cg10802521 chr3:52805072 NEK4 -0.31 -7.95 -0.3 8.27e-15 Bipolar disorder; BRCA cis rs9790314 1.000 rs1993891 chr3:161047467 A/G cg03342759 chr3:160939853 NMD3 -0.65 -13.83 -0.48 3.01e-38 Morning vs. evening chronotype; BRCA cis rs7474896 0.561 rs2474603 chr10:38445682 C/T cg25427524 chr10:38739819 LOC399744 -0.58 -10.0 -0.37 5.82e-22 Obesity (extreme); BRCA cis rs11249608 0.636 rs13359549 chr5:178449178 T/A cg21905437 chr5:178450457 ZNF879 0.5 10.61 0.39 2.55e-24 Pubertal anthropometrics; BRCA cis rs929354 1.000 rs1182414 chr7:157058363 G/A cg17757837 chr7:157058334 UBE3C -0.72 -17.81 -0.58 6.54e-58 Body mass index; BRCA cis rs6461049 0.800 rs3800913 chr7:2163237 A/G cg04267008 chr7:1944627 MAD1L1 -0.48 -10.13 -0.37 1.86e-22 Schizophrenia; BRCA cis rs9649213 0.593 rs10808107 chr7:97951671 T/C cg24562669 chr7:97807699 LMTK2 0.44 11.84 0.42 2.19e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7246657 0.943 rs10407084 chr19:37907792 T/C cg18154014 chr19:37997991 ZNF793 0.62 11.63 0.42 1.75e-28 Coronary artery calcification; BRCA cis rs9807989 0.507 rs4851577 chr2:103028921 T/C cg03938978 chr2:103052716 IL18RAP 0.29 8.37 0.31 3.62e-16 Asthma; BRCA cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.56 -0.47 5.53e-37 Developmental language disorder (linguistic errors); BRCA trans rs9650657 0.562 rs10090444 chr8:10745469 C/G cg15556689 chr8:8085844 FLJ10661 0.38 9.95 0.37 8.97e-22 Neuroticism; BRCA cis rs9457247 0.663 rs9295384 chr6:167448113 T/A cg07741184 chr6:167504864 NA 0.27 8.02 0.3 5.15e-15 Crohn's disease; BRCA cis rs780096 0.525 rs13388159 chr2:27648284 A/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.14 -0.31 2.11e-15 Total body bone mineral density; BRCA cis rs2749592 0.550 rs7081464 chr10:37883937 C/T cg25427524 chr10:38739819 LOC399744 0.58 13.07 0.46 8.93e-35 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10242455 0.557 rs2404487 chr7:99038057 G/A cg18809830 chr7:99032528 PTCD1 -0.63 -8.98 -0.33 3.13e-18 Blood metabolite levels; BRCA cis rs72781680 1.000 rs72796358 chr2:24160132 T/A cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs16866061 1.000 rs17480230 chr2:225399864 G/A cg12698349 chr2:225449008 CUL3 0.79 20.56 0.63 1.72e-72 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs7917772 0.503 rs11191347 chr10:104351617 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.73 0.6 9.84e-63 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2832191 0.791 rs2832196 chr21:30497412 G/A cg24692254 chr21:30365293 RNF160 -0.62 -15.86 -0.53 5.22e-48 Dental caries; BRCA cis rs17376456 0.825 rs17314825 chr5:93234937 A/G cg21475434 chr5:93447410 FAM172A 0.67 8.6 0.32 6.25e-17 Diabetic retinopathy; BRCA cis rs9443645 0.869 rs4706080 chr6:79760997 C/T cg05283184 chr6:79620031 NA -0.42 -10.8 -0.39 4.41e-25 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.500 rs3800902 chr7:2144378 C/T cg04267008 chr7:1944627 MAD1L1 -0.59 -12.32 -0.44 1.93e-31 Bipolar disorder and schizophrenia; BRCA cis rs780096 0.526 rs704795 chr2:27716494 G/A cg22903471 chr2:27725779 GCKR -0.38 -9.29 -0.35 2.33e-19 Total body bone mineral density; BRCA cis rs2732480 0.577 rs2634684 chr12:48730875 C/T cg04545296 chr12:48745243 ZNF641 -0.25 -8.34 -0.31 4.66e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA trans rs877282 0.898 rs11253341 chr10:765008 G/C cg22713356 chr15:30763199 NA 1.3 24.75 0.7 2.51e-95 Uric acid levels; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg24768116 chr2:27665128 KRTCAP3 -0.34 -8.44 -0.32 2.14e-16 Total body bone mineral density; BRCA cis rs9807989 0.507 rs3755266 chr2:103042712 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.39 0.31 3.2e-16 Asthma; BRCA cis rs72627509 0.904 rs58408429 chr4:57769824 T/C cg26694713 chr4:57773883 REST 0.48 9.34 0.35 1.58e-19 Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7811142 0.779 rs77370288 chr7:99947897 A/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 16.95 0.56 1.65e-53 Platelet count; BRCA cis rs344364 0.511 rs911392 chr16:1947259 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.54 -9.76 -0.36 4.35e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs873946 0.564 rs12263364 chr10:134555548 G/T cg06453172 chr10:134556979 INPP5A -0.54 -11.54 -0.42 3.92e-28 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2777491 0.915 rs9302109 chr15:41612180 G/T cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.87 -0.48 1.89e-38 Ulcerative colitis; BRCA cis rs2075371 0.897 rs1643033 chr7:134004662 T/C cg11752832 chr7:134001865 SLC35B4 0.53 13.59 0.47 3.95e-37 Mean platelet volume; BRCA cis rs10782582 0.593 rs17848068 chr1:76190216 G/A cg03433033 chr1:76189801 ACADM -0.51 -10.82 -0.39 3.72e-25 Daytime sleep phenotypes; BRCA cis rs9443189 0.570 rs567903 chr6:76327851 C/T cg01950844 chr6:76311363 SENP6 0.85 13.75 0.48 7.02e-38 Prostate cancer; BRCA cis rs9814567 1.000 rs4974483 chr3:134219001 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.57 -0.61 3.58e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1153858 1.000 rs66939267 chr15:45676902 T/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.63 0.42 1.63e-28 Homoarginine levels; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg00106254 chr7:1943704 MAD1L1 -0.44 -11.85 -0.42 2e-29 Bipolar disorder and schizophrenia; BRCA cis rs7267979 1.000 rs6076339 chr20:25348712 T/C cg08601574 chr20:25228251 PYGB -0.34 -8.06 -0.3 3.75e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7011049 1.000 rs79169015 chr8:53843908 C/T cg26025543 chr8:53854495 NA 0.56 9.66 0.36 1.11e-20 Systolic blood pressure; BRCA cis rs17539620 0.624 rs62432740 chr6:154836054 C/T cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA cis rs8028182 0.636 rs7163451 chr15:75861076 G/T cg20655648 chr15:75932815 IMP3 0.45 8.82 0.33 1.06e-17 Sudden cardiac arrest; BRCA trans rs1005277 0.602 rs1831315 chr10:38473353 T/C cg17830980 chr10:43048298 ZNF37B -0.56 -13.36 -0.47 4.23e-36 Extrinsic epigenetic age acceleration; BRCA cis rs6066835 1.000 rs4431002 chr20:47316585 C/T cg18078177 chr20:47281410 PREX1 0.64 7.92 0.3 1.08e-14 Multiple myeloma; BRCA cis rs12908161 0.959 rs17598603 chr15:85200211 C/G cg17173187 chr15:85201210 NMB -0.43 -8.9 -0.33 5.66e-18 Schizophrenia; BRCA cis rs6665290 0.904 rs6426559 chr1:227195876 T/C cg10327440 chr1:227177885 CDC42BPA -1.15 -48.94 -0.89 2.43e-218 Myeloid white cell count; BRCA cis rs1153858 0.887 rs28569043 chr15:45730926 A/T cg21132104 chr15:45694354 SPATA5L1 0.65 13.37 0.47 3.98e-36 Homoarginine levels; BRCA cis rs10504229 0.728 rs72650861 chr8:58153273 T/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs4853036 1.000 rs6718012 chr2:70078258 T/C cg02498382 chr2:70120550 SNRNP27 -0.5 -9.1 -0.34 1.16e-18 Colorectal or endometrial cancer; BRCA cis rs7552404 0.961 rs1767458 chr1:76219155 A/G cg03433033 chr1:76189801 ACADM 0.73 18.53 0.59 1.12e-61 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs3862030 0.720 rs11191295 chr10:104231054 A/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -12.14 -0.43 1.12e-30 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs7666738 0.546 rs1813970 chr4:98887167 A/G cg05340658 chr4:99064831 C4orf37 -0.54 -10.69 -0.39 1.21e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs13102973 0.965 rs4864244 chr4:135866959 A/G cg14419869 chr4:135874104 NA 0.58 12.96 0.46 2.87e-34 Subjective well-being; BRCA cis rs9314323 0.592 rs12165 chr8:26269412 C/T cg11498726 chr8:26250323 BNIP3L -0.4 -10.14 -0.37 1.7e-22 Red cell distribution width; BRCA cis rs1018836 0.669 rs6471243 chr8:91656967 C/T cg16814680 chr8:91681699 NA 0.82 20.32 0.63 3.36e-71 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs943466 1.000 rs11754690 chr6:33744157 G/A cg25922239 chr6:33757077 LEMD2 -0.39 -7.84 -0.3 1.85e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs528301 0.868 rs542883 chr2:45143382 C/G cg02372786 chr2:45167549 SIX3 -0.52 -11.87 -0.43 1.67e-29 Alcohol and nicotine co-dependence; BRCA cis rs9837602 0.529 rs1688774 chr3:99521108 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.29 0.31 6.67e-16 Breast cancer; BRCA cis rs2576037 0.526 rs10853544 chr18:44474194 T/C cg19077165 chr18:44547161 KATNAL2 -0.52 -11.32 -0.41 3.43e-27 Personality dimensions; BRCA cis rs9976767 0.637 rs9325635 chr21:43823289 G/A cg23042151 chr21:43824109 UBASH3A -0.28 -8.7 -0.33 2.7e-17 Type 1 diabetes; BRCA cis rs12618769 0.652 rs72823801 chr2:99235055 A/G cg10123293 chr2:99228465 UNC50 0.4 7.93 0.3 9.65e-15 Bipolar disorder; BRCA cis rs514406 0.505 rs416968 chr1:53183513 A/G cg24675658 chr1:53192096 ZYG11B -0.58 -13.03 -0.46 1.44e-34 Monocyte count; BRCA cis rs7267979 1.000 rs6050566 chr20:25351071 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -9.12 -0.34 9.31e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17253792 0.598 rs35830444 chr14:56017350 T/C cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs2336384 1.000 rs6668386 chr1:12047233 T/C cg13216073 chr1:12042593 MFN2 0.44 9.41 0.35 8.81e-20 Platelet count; BRCA cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs9443645 0.869 rs2095724 chr6:79742101 C/T cg09184832 chr6:79620586 NA -0.55 -12.1 -0.43 1.76e-30 Intelligence (multi-trait analysis); BRCA cis rs10899021 1.000 rs11236193 chr11:74368307 T/C cg25880958 chr11:74394337 NA -0.53 -8.07 -0.3 3.37e-15 Response to metformin (IC50); BRCA cis rs2204008 0.748 rs7312204 chr12:38334909 T/C cg26384229 chr12:38710491 ALG10B 0.66 15.43 0.52 6.85e-46 Bladder cancer; BRCA cis rs6952808 1.000 rs6953693 chr7:1886388 C/G cg02951883 chr7:2050386 MAD1L1 -0.39 -8.75 -0.33 1.95e-17 Bipolar disorder and schizophrenia; BRCA cis rs10256972 0.706 rs12701970 chr7:1121958 T/C cg18765753 chr7:1198926 ZFAND2A -0.42 -9.66 -0.36 1.1e-20 Longevity;Endometriosis; BRCA cis rs6951245 0.554 rs35126802 chr7:1134842 C/T cg24642844 chr7:1081250 C7orf50 -0.56 -11.39 -0.41 1.8e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7178424 1.000 rs1436963 chr15:62374593 C/T cg00456672 chr15:62358751 C2CD4A -0.35 -8.3 -0.31 6.42e-16 Height; BRCA cis rs2576037 0.899 rs7233515 chr18:44585955 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.43 -8.82 -0.33 1.07e-17 Personality dimensions; BRCA cis rs559928 0.947 rs12417275 chr11:64143774 A/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.66 9.65 0.36 1.21e-20 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA trans rs1941687 0.583 rs8091977 chr18:31359414 T/C cg27147174 chr7:100797783 AP1S1 -0.42 -8.36 -0.31 3.85e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA trans rs7618501 0.633 rs7628058 chr3:50039474 C/T cg21659725 chr3:3221576 CRBN 0.48 12.39 0.44 9.4e-32 Intelligence (multi-trait analysis); BRCA cis rs523522 0.962 rs4767914 chr12:120993817 C/T cg12219531 chr12:120966889 COQ5 0.55 11.44 0.41 1.07e-27 High light scatter reticulocyte count; BRCA cis rs3741404 0.620 rs11231722 chr11:63967770 C/G cg18225595 chr11:63971243 STIP1 0.42 10.64 0.39 1.8e-24 Platelet count; BRCA cis rs3815700 1.000 rs8108840 chr19:33094452 A/C cg02997394 chr19:33096574 ANKRD27 0.66 11.09 0.4 2.89e-26 Eosinophilic esophagitis; BRCA cis rs9837602 0.935 rs9810235 chr3:99736538 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.59 11.1 0.4 2.74e-26 Breast cancer; BRCA cis rs3772130 0.961 rs13072618 chr3:121391833 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.38 0.35 1.16e-19 Cognitive performance; BRCA trans rs9951602 0.512 rs9958376 chr18:76655167 G/T cg02800362 chr5:177631904 HNRNPAB 0.78 18.13 0.58 1.44e-59 Obesity-related traits; BRCA cis rs11945232 0.929 rs28736552 chr4:88356111 T/C cg23841344 chr4:88312519 HSD17B11 -0.46 -9.2 -0.34 4.98e-19 Intelligence (multi-trait analysis); BRCA cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg06453172 chr10:134556979 INPP5A 0.59 12.64 0.45 7.68e-33 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg11764359 chr7:65958608 NA -0.75 -16.53 -0.55 2.26e-51 Aortic root size; BRCA cis rs875971 0.522 rs2949690 chr7:65483242 C/T cg18876405 chr7:65276391 NA -0.7 -18.44 -0.59 3.26e-61 Aortic root size; BRCA cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg14664628 chr15:75095509 CSK -0.53 -12.59 -0.45 1.25e-32 Breast cancer; BRCA cis rs6952808 1.000 rs6957894 chr7:1887362 G/A cg22963979 chr7:1858916 MAD1L1 -0.4 -8.54 -0.32 9.75e-17 Bipolar disorder and schizophrenia; BRCA trans rs8073060 0.586 rs225288 chr17:33929291 G/A cg19694781 chr19:47549865 TMEM160 -1.06 -21.28 -0.64 2.4e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs13108904 0.518 rs4974602 chr4:1342391 C/T cg01939980 chr4:1354348 KIAA1530 0.38 8.92 0.33 4.8e-18 Obesity-related traits; BRCA cis rs1862618 0.853 rs252898 chr5:56188931 T/C cg24531977 chr5:56204891 C5orf35 -0.88 -18.88 -0.6 1.53e-63 Initial pursuit acceleration; BRCA cis rs826838 1.000 rs10880785 chr12:38655405 T/G cg26384229 chr12:38710491 ALG10B 0.85 22.92 0.67 2.58e-85 Heart rate; BRCA cis rs7772486 0.875 rs9403763 chr6:146357655 A/G cg13319975 chr6:146136371 FBXO30 -0.37 -8.44 -0.32 2.09e-16 Lobe attachment (rater-scored or self-reported); BRCA trans rs10028773 0.600 rs4001390 chr4:120265783 G/C cg25214090 chr10:38739885 LOC399744 0.43 10.0 0.37 5.45e-22 Educational attainment; BRCA cis rs7715806 0.500 rs72633982 chr5:75001321 C/T cg19683494 chr5:74908142 NA 0.53 8.61 0.32 5.76e-17 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1005277 0.522 rs11011343 chr10:38002698 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -15.65 -0.53 5.73e-47 Extrinsic epigenetic age acceleration; BRCA cis rs2153535 0.580 rs1360054 chr6:8520377 C/A cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.27e-41 Motion sickness; BRCA cis rs13191362 0.935 rs67084568 chr6:162988548 C/A cg06582575 chr6:163149167 PACRG;PARK2 0.83 12.84 0.45 9.76e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1950500 0.545 rs1950501 chr14:24806800 C/G cg16194253 chr14:24768981 DHRS1;C14orf21 0.39 8.05 0.3 4e-15 Height; BRCA cis rs2991971 0.810 rs781058 chr1:45935056 C/G cg15605315 chr1:45957053 TESK2 -0.44 -8.74 -0.33 2.08e-17 High light scatter reticulocyte count; BRCA trans rs11098499 0.863 rs3775847 chr4:120447642 A/C cg25214090 chr10:38739885 LOC399744 0.56 12.45 0.44 5.14e-32 Corneal astigmatism; BRCA cis rs4665809 0.652 rs6727974 chr2:26524639 A/G cg27170947 chr2:26402098 FAM59B 0.71 13.07 0.46 9.11e-35 Gut microbiome composition (summer); BRCA cis rs4689592 0.619 rs2359011 chr4:7066052 T/G cg19539972 chr4:7069911 GRPEL1 0.68 16.79 0.55 1.12e-52 Monocyte percentage of white cells; BRCA cis rs7523050 0.730 rs72984628 chr1:109460808 G/A cg08274380 chr1:109419600 GPSM2 0.96 14.13 0.49 1.19e-39 Fat distribution (HIV); BRCA cis rs751728 0.664 rs4711349 chr6:33740592 C/T cg25922239 chr6:33757077 LEMD2 0.52 13.18 0.46 2.84e-35 Crohn's disease; BRCA cis rs10267417 0.657 rs7800274 chr7:19871184 G/T cg07541023 chr7:19748670 TWISTNB 0.51 9.14 0.34 8.14e-19 Night sleep phenotypes; BRCA cis rs17401966 1.000 rs12129035 chr1:10291166 G/A cg03954927 chr1:10346856 KIF1B 0.44 13.05 0.46 1.08e-34 Hepatocellular carcinoma; BRCA cis rs2624839 0.704 rs14321 chr3:50226151 T/C cg05623727 chr3:50126028 RBM5 -0.37 -8.06 -0.3 3.86e-15 Intelligence (multi-trait analysis); BRCA cis rs9733 0.596 rs2867304 chr1:150630995 G/A cg18016565 chr1:150552671 MCL1 0.35 8.23 0.31 1.08e-15 Tonsillectomy; BRCA cis rs1062753 0.961 rs9620007 chr22:42405657 C/G cg22189786 chr22:42395067 WBP2NL 0.43 8.64 0.32 4.43e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg18402987 chr7:1209562 NA 0.85 12.04 0.43 2.97e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6938 0.534 rs1130741 chr15:75189930 A/G cg13906792 chr15:75199810 C15orf17 -0.39 -9.17 -0.34 6.5e-19 Breast cancer; BRCA cis rs11190604 0.767 rs872290 chr10:102198879 G/A cg07080220 chr10:102295463 HIF1AN 0.44 9.77 0.36 4.16e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs13046373 0.535 rs2832970 chr21:32020767 T/C cg24082983 chr21:31802169 KRTAP13-4 0.32 8.16 0.31 1.74e-15 HDL cholesterol; BRCA cis rs113835537 0.529 rs7950790 chr11:66258053 G/A cg24851651 chr11:66362959 CCS 0.41 7.91 0.3 1.16e-14 Airway imaging phenotypes; BRCA cis rs10751667 0.666 rs7394427 chr11:970405 G/A cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs6951245 0.638 rs4720486 chr7:1146764 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -13.1 -0.46 6.65e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9291683 0.575 rs3756223 chr4:10105797 C/T cg00071950 chr4:10020882 SLC2A9 0.47 11.35 0.41 2.48e-27 Bone mineral density; BRCA cis rs736408 0.546 rs3733046 chr3:52621627 C/T cg18404041 chr3:52824283 ITIH1 -0.39 -11.92 -0.43 1.05e-29 Bipolar disorder; BRCA cis rs13191362 0.507 rs2849511 chr6:163139050 C/G cg21926612 chr6:163149169 PACRG;PARK2 -0.55 -10.53 -0.38 5.26e-24 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs66893068 chr8:58144238 A/G cg22535103 chr8:58192502 C8orf71 -0.44 -8.83 -0.33 9.86e-18 Developmental language disorder (linguistic errors); BRCA cis rs1506636 0.889 rs619075 chr7:123426317 A/T cg03229431 chr7:123269106 ASB15 0.61 13.53 0.47 7.36e-37 Plateletcrit;Platelet count; BRCA cis rs7613875 0.600 rs2624832 chr3:50030858 C/T cg14019146 chr3:50243930 SLC38A3 -0.42 -10.18 -0.37 1.18e-22 Body mass index; BRCA cis rs9814567 0.793 rs55940445 chr3:134306064 G/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.23 0.61 2.28e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2836974 0.583 rs9981884 chr21:40585633 G/A cg11644478 chr21:40555479 PSMG1 0.5 10.2 0.37 9.6e-23 Cognitive function; BRCA cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg13010199 chr12:38710504 ALG10B 0.55 11.89 0.43 1.39e-29 Heart rate; BRCA cis rs1003719 0.715 rs2835642 chr21:38539066 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg02261765 chr11:831170 EFCAB4A -0.39 -8.48 -0.32 1.53e-16 Mean platelet volume; BRCA cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg06627628 chr2:24431161 ITSN2 -0.85 -15.66 -0.53 5.08e-47 Asthma; BRCA cis rs12545109 0.800 rs1467123 chr8:57418870 C/T cg09654669 chr8:57350985 NA -0.39 -8.74 -0.33 2.11e-17 Obesity-related traits; BRCA cis rs7520050 0.902 rs4626927 chr1:46248645 C/T cg24296786 chr1:45957014 TESK2 0.44 10.01 0.37 5.02e-22 Red blood cell count;Reticulocyte count; BRCA cis rs10267417 0.603 rs10258555 chr7:19868344 T/G cg05791153 chr7:19748676 TWISTNB 0.51 9.81 0.36 3.01e-21 Night sleep phenotypes; BRCA cis rs514406 0.929 rs557715 chr1:53321593 C/G cg01802117 chr1:53393560 SCP2 -0.35 -8.17 -0.31 1.68e-15 Monocyte count; BRCA cis rs9287719 0.649 rs10202370 chr2:10727043 T/C cg00105475 chr2:10696890 NA 0.41 9.2 0.34 5.17e-19 Prostate cancer; BRCA cis rs16866061 0.515 rs11695326 chr2:225415134 A/G cg12698349 chr2:225449008 CUL3 0.85 29.62 0.76 5.2e-122 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2404602 0.716 rs17364076 chr15:76760891 C/T cg26408565 chr15:76604113 ETFA -0.47 -9.97 -0.37 7.26e-22 Blood metabolite levels; BRCA cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.36 8.73 0.33 2.15e-17 Personality dimensions; BRCA trans rs62578126 0.695 rs10760444 chr9:129396434 C/T cg12286636 chr12:27933133 KLHDC5 0.38 9.67 0.36 1.02e-20 Eyebrow thickness; BRCA cis rs10089 1.000 rs72794396 chr5:127501386 G/A cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.66 14.47 0.5 2.94e-41 Ileal carcinoids; BRCA cis rs6952808 0.895 rs12669518 chr7:1921429 G/C cg02951883 chr7:2050386 MAD1L1 -0.48 -11.13 -0.4 2.09e-26 Bipolar disorder and schizophrenia; BRCA cis rs311392 0.967 rs4255114 chr8:55089450 G/A cg11783602 chr8:55087084 NA -0.32 -9.49 -0.35 4.38e-20 Pelvic organ prolapse (moderate/severe); BRCA cis rs2762353 0.904 rs13197601 chr6:25785935 G/A cg03517284 chr6:25882590 NA 0.48 10.84 0.39 3.03e-25 Blood metabolite levels; BRCA cis rs838147 0.508 rs507766 chr19:49208543 T/C cg07051648 chr19:49177693 NTN5;SEC1 -0.43 -8.04 -0.3 4.44e-15 Dietary macronutrient intake; BRCA cis rs2749592 0.550 rs10764135 chr10:37866845 C/T cg25427524 chr10:38739819 LOC399744 0.58 13.15 0.46 3.86e-35 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2051211 0.947 rs73065216 chr3:38524194 G/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.53 -10.36 -0.38 2.27e-23 QRS duration; BRCA cis rs11608355 0.545 rs2302707 chr12:109893797 G/A cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA cis rs738322 0.805 rs2016755 chr22:38539604 A/G cg20207973 chr22:38506712 BAIAP2L2 0.32 8.1 0.31 2.75e-15 Cutaneous nevi; BRCA cis rs6570726 0.526 rs72994723 chr6:145722948 G/A cg23711669 chr6:146136114 FBXO30 -0.44 -9.59 -0.35 1.9e-20 Lobe attachment (rater-scored or self-reported); BRCA trans rs11039798 0.688 rs10839007 chr11:48703442 A/C cg15704280 chr7:45808275 SEPT13 0.59 8.79 0.33 1.39e-17 Axial length; BRCA cis rs9818758 0.607 rs9837237 chr3:49215583 G/T cg00383909 chr3:49044727 WDR6 0.73 12.69 0.45 4.51e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg11905131 chr22:24372483 LOC391322 -0.52 -11.79 -0.42 3.57e-29 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7072216 0.763 rs7910014 chr10:100172110 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.68 -0.36 9.24e-21 Metabolite levels; BRCA cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg17971929 chr21:40555470 PSMG1 -0.51 -11.34 -0.41 2.75e-27 Menarche (age at onset); BRCA cis rs10504229 0.906 rs73607869 chr8:58172665 G/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs992157 0.932 rs56109829 chr2:219149740 G/A cg20019365 chr2:219134978 PNKD;AAMP 0.62 14.05 0.49 3.01e-39 Colorectal cancer; BRCA cis rs79976124 0.876 rs17511913 chr6:66644361 C/T cg07460842 chr6:66804631 NA 0.62 11.13 0.4 2.1e-26 Type 2 diabetes; BRCA cis rs7613875 0.600 rs2856237 chr3:50158774 A/G cg05623727 chr3:50126028 RBM5 -0.51 -12.7 -0.45 3.97e-33 Body mass index; BRCA cis rs910316 0.763 rs175036 chr14:75464295 C/T cg11812906 chr14:75593930 NEK9 -0.63 -14.62 -0.5 5.46e-42 Height; BRCA cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg17330251 chr7:94953956 PON1 -0.42 -8.79 -0.33 1.39e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7618915 0.570 rs11714088 chr3:52758942 A/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.99 0.37 6.2e-22 Bipolar disorder; BRCA cis rs8031584 0.958 rs7168641 chr15:31235452 G/A cg14829155 chr15:31115871 NA -0.43 -10.14 -0.37 1.72e-22 Huntington's disease progression; BRCA cis rs9309473 0.606 rs77962988 chr2:73886090 T/C cg20560298 chr2:73613845 ALMS1 -0.44 -7.98 -0.3 6.64e-15 Metabolite levels; BRCA cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2806561 0.765 rs668234 chr1:23515467 G/A cg12483005 chr1:23474871 LUZP1 0.44 9.81 0.36 2.84e-21 Height; BRCA cis rs7666738 0.830 rs4472144 chr4:98956494 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.81 0.3 2.37e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs6815814 0.898 rs1873195 chr4:38891173 C/T cg02016764 chr4:38805732 TLR1 -0.49 -8.19 -0.31 1.41e-15 Breast cancer; BRCA cis rs7589728 1.000 rs2363731 chr2:88521793 C/T cg04511125 chr2:88470314 THNSL2 0.79 11.39 0.41 1.74e-27 Plasma clusterin levels; BRCA cis rs7811142 1.000 rs11763414 chr7:100016844 C/G cg11814155 chr7:99998594 ZCWPW1 0.48 8.59 0.32 6.58e-17 Platelet count; BRCA cis rs1707322 1.000 rs12097799 chr1:46459886 C/A cg06784218 chr1:46089804 CCDC17 0.45 10.76 0.39 6.28e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs7824557 0.734 rs2293856 chr8:11177447 C/T cg06636001 chr8:8085503 FLJ10661 0.55 10.34 0.38 2.79e-23 Retinal vascular caliber; BRCA trans rs9388451 0.626 rs9385383 chr6:126086290 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.56 -14.06 -0.49 2.67e-39 Brugada syndrome; BRCA cis rs60871478 1.000 rs4374882 chr7:821798 C/T cg27478167 chr7:817139 HEATR2 -0.43 -9.22 -0.34 4.38e-19 Cerebrospinal P-tau181p levels; BRCA cis rs6545883 0.860 rs777589 chr2:61425621 T/C cg15711740 chr2:61764176 XPO1 -0.52 -13.25 -0.46 1.42e-35 Tuberculosis; BRCA cis rs9811920 0.570 rs1021102 chr3:99603780 T/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G 0.39 7.9 0.3 1.19e-14 Axial length; BRCA cis rs198389 0.589 rs198391 chr1:11876417 C/T cg06193043 chr1:11908199 NPPA 0.31 7.93 0.3 9.46e-15 B-type natriuretic peptide levels;NT-proBNP levels in acute coronary syndrome; BRCA cis rs7772486 0.790 rs6917482 chr6:146243581 C/T cg13319975 chr6:146136371 FBXO30 0.41 9.25 0.34 3.38e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs7824557 0.767 rs1897951 chr8:11169854 C/T cg08975724 chr8:8085496 FLJ10661 0.43 8.05 0.3 4.12e-15 Retinal vascular caliber; BRCA trans rs4714291 0.925 rs847750 chr6:40074250 G/A cg02267698 chr19:7991119 CTXN1 0.42 8.17 0.31 1.64e-15 Strep throat; BRCA cis rs10479542 0.896 rs4701131 chr5:178982446 A/G cg19626725 chr5:178986131 RUFY1 0.35 10.66 0.39 1.5e-24 Lung cancer; BRCA cis rs11920090 0.858 rs66683764 chr3:170720960 A/G cg09710316 chr3:170744871 SLC2A2 0.58 9.65 0.36 1.19e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg08999081 chr20:33150536 PIGU -0.44 -11.97 -0.43 6.38e-30 Glomerular filtration rate (creatinine); BRCA trans rs1973993 0.561 rs4127308 chr1:96990754 G/C cg10631902 chr5:14652156 NA -0.39 -9.87 -0.36 1.82e-21 Weight; BRCA cis rs1538970 0.851 rs2055145 chr1:45926495 C/G cg05343316 chr1:45956843 TESK2 0.66 13.63 0.47 2.51e-37 Platelet count; BRCA cis rs7493 1.000 rs7493 chr7:95034775 C/G cg17330251 chr7:94953956 PON1 0.43 9.19 0.34 5.61e-19 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs3857536 0.719 rs9363555 chr6:66930332 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.1 -0.31 2.78e-15 Blood trace element (Cu levels); BRCA cis rs796364 0.806 rs203765 chr2:200903020 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.66 -10.45 -0.38 1.09e-23 Schizophrenia; BRCA cis rs977987 0.778 rs4888400 chr16:75425596 G/C cg03315344 chr16:75512273 CHST6 0.52 12.32 0.44 1.83e-31 Dupuytren's disease; BRCA cis rs7617773 0.963 rs12494304 chr3:48178029 C/T cg11946769 chr3:48343235 NME6 -0.39 -8.47 -0.32 1.69e-16 Coronary artery disease; BRCA cis rs7618915 0.501 rs2164885 chr3:52731269 T/C cg10802521 chr3:52805072 NEK4 -0.34 -9.3 -0.35 2.22e-19 Bipolar disorder; BRCA trans rs28735056 0.609 rs4799099 chr18:77639585 A/G cg05926928 chr17:57297772 GDPD1 0.52 10.61 0.39 2.41e-24 Schizophrenia; BRCA cis rs4466137 0.903 rs3734092 chr5:83016743 C/T cg16102102 chr5:83017553 HAPLN1 -0.92 -18.5 -0.59 1.69e-61 Prostate cancer; BRCA cis rs1552244 1.000 rs6786638 chr3:10118075 G/C cg18598329 chr3:10140678 FANCD2;C3orf24 -0.68 -12.8 -0.45 1.41e-33 Alzheimer's disease; BRCA cis rs1371867 0.764 rs1020171 chr8:101288610 T/C cg06002616 chr8:101225028 SPAG1 -0.34 -8.28 -0.31 7.37e-16 Atrioventricular conduction; BRCA cis rs2836974 0.623 rs34240248 chr21:40685239 A/G cg06238570 chr21:40685208 BRWD1 -0.46 -9.06 -0.34 1.61e-18 Cognitive function; BRCA cis rs3772130 0.962 rs4280673 chr3:121526107 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.58 10.91 0.4 1.63e-25 Cognitive performance; BRCA cis rs2762353 0.553 rs9467581 chr6:25710548 C/T cg03517284 chr6:25882590 NA 0.67 15.19 0.52 1.01e-44 Blood metabolite levels; BRCA cis rs3771570 1.000 rs73004354 chr2:242356239 G/T cg21155796 chr2:242212141 HDLBP 0.61 9.26 0.34 3.11e-19 Prostate cancer; BRCA cis rs1829883 0.835 rs2461972 chr5:98776454 G/A cg08333243 chr5:99726346 NA -0.35 -7.82 -0.3 2.23e-14 Hemostatic factors and hematological phenotypes; BRCA cis rs367943 1.000 rs348956 chr5:112821464 C/T cg12552261 chr5:112820674 MCC 0.55 12.1 0.43 1.66e-30 Type 2 diabetes; BRCA cis rs11874712 1.000 rs7244950 chr18:43676523 G/C cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.05 0.3 4.16e-15 Migraine - clinic-based; BRCA cis rs61990749 0.597 rs176955 chr14:78181220 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.62 9.73 0.36 5.8e-21 Fibroblast growth factor basic levels; BRCA cis rs9486719 0.843 rs2499796 chr6:96848364 A/G cg06623918 chr6:96969491 KIAA0776 0.72 12.33 0.44 1.69e-31 Migraine;Coronary artery disease; BRCA cis rs68170813 0.559 rs6964966 chr7:106933099 C/G cg02696742 chr7:106810147 HBP1 -0.53 -8.7 -0.33 2.87e-17 Coronary artery disease; BRCA cis rs3008870 1.000 rs3008855 chr1:67386204 A/G cg08660285 chr1:67390436 MIER1;WDR78 -0.94 -20.02 -0.62 1.37e-69 Lymphocyte percentage of white cells; BRCA cis rs4073582 0.595 rs801739 chr11:65922589 A/G cg14036092 chr11:66035641 RAB1B 0.38 10.13 0.37 1.88e-22 Gout; BRCA cis rs933688 0.938 rs10063683 chr5:90714595 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.87 18.79 0.6 4.58e-63 Smoking behavior; BRCA cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg04733989 chr22:42467013 NAGA -0.41 -8.84 -0.33 9.17e-18 Cognitive function; BRCA cis rs4481887 0.927 rs6587444 chr1:248438452 C/T cg00666640 chr1:248458726 OR2T12 -0.34 -9.38 -0.35 1.09e-19 Common traits (Other); BRCA cis rs10464366 0.544 rs12701697 chr7:39182165 C/T cg18850127 chr7:39170497 POU6F2 0.54 11.82 0.42 2.62e-29 IgG glycosylation; BRCA cis rs7666738 0.830 rs13133355 chr4:98919415 A/G cg17366294 chr4:99064904 C4orf37 0.41 9.73 0.36 6e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2073300 1.000 rs34449811 chr20:23443771 T/C cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs72781680 1.000 rs75046532 chr2:24167267 A/G cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs55665837 1.000 rs10047429 chr11:14439032 C/T cg19336497 chr11:14380999 RRAS2 -0.36 -9.48 -0.35 4.83e-20 Vitamin D levels; BRCA cis rs10504229 0.683 rs17194995 chr8:58109220 A/C cg08280861 chr8:58055591 NA -0.55 -8.81 -0.33 1.2e-17 Developmental language disorder (linguistic errors); BRCA cis rs1215050 0.716 rs356549 chr4:98699344 A/G cg05340658 chr4:99064831 C4orf37 0.45 10.42 0.38 1.42e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2153535 0.584 rs9502723 chr6:8541504 G/A cg07606381 chr6:8435919 SLC35B3 0.64 14.03 0.49 3.61e-39 Motion sickness; BRCA cis rs6543140 0.964 rs2310301 chr2:103072935 C/T cg04239558 chr2:103089729 SLC9A4 0.34 9.56 0.35 2.4e-20 Blood protein levels; BRCA cis rs2464469 0.654 rs4646570 chr15:58343146 G/C cg12031962 chr15:58353849 ALDH1A2 -0.35 -9.01 -0.34 2.29e-18 Barrett's esophagus or Esophageal adenocarcinoma; BRCA cis rs7520050 0.902 rs9429088 chr1:46497500 T/A cg24296786 chr1:45957014 TESK2 0.4 8.84 0.33 9.43e-18 Red blood cell count;Reticulocyte count; BRCA cis rs10751667 0.621 rs11246345 chr11:934924 T/C cg10932868 chr11:921992 NA 0.5 12.85 0.45 8.49e-34 Alzheimer's disease (late onset); BRCA cis rs34311866 0.808 rs62294491 chr4:969111 C/T cg07828340 chr4:882639 GAK 0.86 10.44 0.38 1.15e-23 Parkinson's disease; BRCA cis rs41005 0.597 rs35400177 chr2:8101757 C/T cg03155496 chr2:8117019 LOC339788 -0.5 -11.91 -0.43 1.13e-29 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs11098499 0.874 rs28452522 chr4:120110784 A/G cg09307838 chr4:120376055 NA 0.61 11.2 0.41 1.06e-26 Corneal astigmatism; BRCA cis rs4689388 0.750 rs10755148 chr4:6295064 A/G cg00701064 chr4:6280414 WFS1 0.66 15.68 0.53 4.11e-47 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs12762955 0.507 rs10737004 chr10:1039019 T/C cg19847866 chr10:1019161 NA 0.49 10.2 0.37 9.8e-23 Response to angiotensin II receptor blocker therapy; BRCA cis rs9733 0.744 rs4970976 chr1:150779524 T/A cg18016565 chr1:150552671 MCL1 -0.37 -8.5 -0.32 1.3e-16 Tonsillectomy; BRCA cis rs1008375 0.931 rs10019482 chr4:17578079 G/A cg04450456 chr4:17643702 FAM184B 0.42 12.73 0.45 2.88e-33 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs16867321 0.950 rs1919152 chr2:181507765 C/T cg23363182 chr2:181467187 NA -0.44 -8.19 -0.31 1.42e-15 Obesity; BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.64 -12.1 -0.43 1.65e-30 Gut microbiome composition (summer); BRCA cis rs4819052 0.851 rs1056101 chr21:46678702 C/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.45 8.63 0.32 4.99e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2806561 0.929 rs6694445 chr1:23540428 A/G cg19743168 chr1:23544995 NA 0.45 11.12 0.4 2.31e-26 Height; BRCA cis rs9926296 0.715 rs467035 chr16:89740285 C/G cg03605463 chr16:89740564 NA -0.63 -11.28 -0.41 4.99e-27 Vitiligo; BRCA cis rs7072216 0.690 rs113195335 chr10:100175532 A/C cg26618903 chr10:100175079 PYROXD2 -0.33 -9.7 -0.36 7.5e-21 Metabolite levels; BRCA cis rs17092148 1.000 rs17092148 chr20:33435161 A/C cg16810054 chr20:33298113 TP53INP2 -0.45 -10.02 -0.37 4.59e-22 Neuroticism; BRCA cis rs826838 0.967 rs826855 chr12:39114888 T/C cg13010199 chr12:38710504 ALG10B -0.43 -10.01 -0.37 5.32e-22 Heart rate; BRCA cis rs736408 0.562 rs2072390 chr3:52780509 A/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 12.32 0.44 1.94e-31 Bipolar disorder; BRCA cis rs67981189 0.865 rs2810117 chr14:71391025 T/C cg15816911 chr14:71606274 NA -0.37 -8.25 -0.31 9.29e-16 Schizophrenia; BRCA cis rs7918232 0.567 rs4749215 chr10:27312005 T/C cg14442939 chr10:27389572 ANKRD26 0.46 8.52 0.32 1.12e-16 Breast cancer; BRCA cis rs1448094 0.511 rs10863083 chr12:86226739 C/A cg19622623 chr12:86230825 RASSF9 -0.34 -9.43 -0.35 7.52e-20 Major depressive disorder; BRCA cis rs12497850 0.866 rs6791234 chr3:48996137 A/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.34 0.35 1.53e-19 Parkinson's disease; BRCA cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.45 -0.38 1.05e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6435161 1.000 rs6435161 chr2:203519783 T/G cg18429434 chr2:203499731 FAM117B -0.44 -8.76 -0.33 1.78e-17 Total cholesterol levels; BRCA cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.14 0.37 1.68e-22 Aortic root size; BRCA cis rs7607369 0.580 rs17573724 chr2:219652141 T/A cg02176678 chr2:219576539 TTLL4 -0.48 -12.9 -0.45 5.31e-34 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs7914558 0.966 rs11191518 chr10:104782853 C/G cg04362960 chr10:104952993 NT5C2 0.43 10.51 0.38 6.22e-24 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs28374715 0.662 rs11852419 chr15:41456374 A/T cg18705301 chr15:41695430 NDUFAF1 0.71 14.43 0.5 4.72e-41 Ulcerative colitis; BRCA cis rs7772486 0.754 rs9497434 chr6:146260753 C/T cg23711669 chr6:146136114 FBXO30 -0.77 -17.93 -0.58 1.6e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs250677 0.687 rs40522 chr5:148442295 G/A cg18129178 chr5:148520854 ABLIM3 -0.58 -11.65 -0.42 1.44e-28 Breast cancer; BRCA cis rs10465746 0.570 rs11163887 chr1:84474718 C/T cg10977910 chr1:84465055 TTLL7 0.55 11.38 0.41 1.85e-27 Obesity-related traits; BRCA cis rs75229567 0.717 rs17107156 chr12:70234066 A/G cg10114359 chr12:70132523 RAB3IP -0.59 -8.65 -0.32 4.3e-17 Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes; BRCA cis rs1215050 0.791 rs7688192 chr4:98900798 G/T cg05340658 chr4:99064831 C4orf37 -0.43 -9.81 -0.36 2.98e-21 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4671400 0.571 rs12615222 chr2:61494895 C/T cg15711740 chr2:61764176 XPO1 0.4 7.9 0.3 1.19e-14 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs936229 0.813 rs4886619 chr15:75106138 C/T cg10253484 chr15:75165896 SCAMP2 -0.5 -9.79 -0.36 3.53e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7246657 0.722 rs2927742 chr19:38133618 T/C cg14683738 chr19:37701593 ZNF585B -0.46 -7.84 -0.3 1.96e-14 Coronary artery calcification; BRCA cis rs10504073 0.584 rs17642664 chr8:49942945 A/G cg00325661 chr8:49890786 NA 0.47 13.74 0.48 8.37e-38 Blood metabolite ratios; BRCA trans rs9914544 1.000 rs1037036 chr17:18764077 C/T cg04702396 chr17:15466718 FAM18B2 0.4 7.81 0.3 2.35e-14 Educational attainment (years of education); BRCA cis rs1552244 1.000 rs7615764 chr3:10082592 C/T cg13047869 chr3:10149882 C3orf24 0.58 12.2 0.43 6.43e-31 Alzheimer's disease; BRCA cis rs7666738 0.753 rs13120995 chr4:98972762 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.526 rs2571027 chr18:44561516 C/G cg19077165 chr18:44547161 KATNAL2 0.55 12.19 0.43 6.77e-31 Personality dimensions; BRCA cis rs55882075 0.537 rs62406698 chr5:179110429 C/T cg14593053 chr5:179126677 CANX 0.4 9.9 0.36 1.35e-21 Monocyte percentage of white cells; BRCA cis rs523522 0.962 rs10744752 chr12:120900554 T/G cg27279351 chr12:120934652 DYNLL1 0.52 12.24 0.44 4.28e-31 High light scatter reticulocyte count; BRCA cis rs79839061 0.610 rs2279181 chr4:882643 A/G cg14530993 chr4:882597 GAK -0.53 -9.88 -0.36 1.65e-21 Intelligence (multi-trait analysis); BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg00106254 chr7:1943704 MAD1L1 -0.43 -10.51 -0.38 6.14e-24 Bipolar disorder and schizophrenia; BRCA cis rs13118159 0.509 rs4974556 chr4:1358141 G/C cg02475777 chr4:1388615 CRIPAK 0.67 13.04 0.46 1.3e-34 Longevity; BRCA cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.35 8.35 0.31 4.1e-16 Tonsillectomy; BRCA trans rs11098499 0.818 rs10008791 chr4:120431469 A/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.13 0.31 2.16e-15 Corneal astigmatism; BRCA cis rs13315871 0.929 rs7643185 chr3:58311158 A/C cg12435725 chr3:58293450 RPP14 0.47 7.91 0.3 1.13e-14 Cholesterol, total; BRCA cis rs9790314 0.589 rs9790132 chr3:160627289 A/T cg03342759 chr3:160939853 NMD3 0.42 8.11 0.31 2.63e-15 Morning vs. evening chronotype; BRCA cis rs738322 1.000 rs4381 chr22:38570791 T/C cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA cis rs9814567 0.806 rs2293294 chr3:134322814 G/C cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.26 0.31 8.36e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7937890 0.967 rs963212 chr11:14324732 A/G cg19336497 chr11:14380999 RRAS2 0.3 7.98 0.3 6.72e-15 Mitochondrial DNA levels; BRCA cis rs870825 0.698 rs72703549 chr4:185623963 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs13191362 1.000 rs67840803 chr6:163049048 C/T cg18825119 chr6:163149453 PACRG;PARK2 0.52 7.98 0.3 6.57e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6570726 0.599 rs426371 chr6:145886469 A/G cg05347473 chr6:146136440 FBXO30 -0.64 -12.53 -0.44 2.25e-32 Lobe attachment (rater-scored or self-reported); BRCA cis rs9443645 0.838 rs946022 chr6:79672133 G/T cg11833968 chr6:79620685 NA -0.45 -10.03 -0.37 4.43e-22 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs7275874 chr21:46671223 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.31 0.49 1.76e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs61990749 0.597 rs72685264 chr14:78152998 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.62 -9.53 -0.35 3.28e-20 Fibroblast growth factor basic levels; BRCA trans rs877282 0.898 rs11253347 chr10:765769 A/G cg22713356 chr15:30763199 NA 1.29 24.0 0.69 3.29e-91 Uric acid levels; BRCA cis rs7666738 0.753 rs2865957 chr4:99040725 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.62 0.55 8.44e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs2625529 0.824 rs12595464 chr15:72294398 C/T cg16672083 chr15:72433130 SENP8 -0.85 -17.53 -0.57 1.89e-56 Red blood cell count; BRCA cis rs2742234 0.541 rs61268333 chr10:43721370 G/A cg02780029 chr10:43622663 RET 0.35 7.86 0.3 1.69e-14 Hirschsprung disease; BRCA cis rs9831754 0.865 rs9842838 chr3:78387904 A/C cg06138941 chr3:78371609 NA -0.76 -16.49 -0.55 3.72e-51 Calcium levels; BRCA cis rs10256972 0.630 rs13235747 chr7:1129123 T/C cg23978390 chr7:1156363 C7orf50 0.5 11.61 0.42 2.16e-28 Longevity;Endometriosis; BRCA cis rs4919087 0.923 rs11189037 chr10:98974707 C/G cg25902810 chr10:99078978 FRAT1 0.43 8.8 0.33 1.26e-17 Monocyte count; BRCA cis rs7568458 0.684 rs1048740 chr2:85764966 A/T cg02493740 chr2:85810744 VAMP5 -0.53 -11.07 -0.4 3.46e-26 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7733403 1 rs7733403 chr5:140154215 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.45 -10.36 -0.38 2.37e-23 Schizophrenia; BRCA trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg00717180 chr2:96193071 NA -0.31 -8.71 -0.33 2.6e-17 HDL cholesterol; BRCA cis rs765787 0.530 rs11636018 chr15:45539137 T/C cg15395560 chr15:45543142 SLC28A2 0.29 8.12 0.31 2.49e-15 Uric acid levels; BRCA cis rs11809207 0.574 rs2783630 chr1:26504741 G/A cg00147160 chr1:26503991 CNKSR1 0.28 9.42 0.35 7.8e-20 Height; BRCA trans rs9409565 0.826 rs9409778 chr9:97242839 G/A cg05679027 chr9:99775184 HIATL2 -0.42 -9.23 -0.34 3.89e-19 Colorectal cancer (alcohol consumption interaction); BRCA cis rs704795 0.836 rs1647281 chr2:27612938 G/C cg22903471 chr2:27725779 GCKR -0.38 -9.15 -0.34 7.38e-19 Menopause (age at onset); BRCA cis rs10751667 1.000 rs12798036 chr11:947585 T/C ch.11.42038R chr11:967971 AP2A2 0.58 19.04 0.6 2.45e-64 Alzheimer's disease (late onset); BRCA trans rs2727020 0.554 rs2866490 chr11:49425463 A/G cg03929089 chr4:120376271 NA -0.66 -12.87 -0.45 7.18e-34 Coronary artery disease; BRCA cis rs6088590 1.000 rs6087623 chr20:33317662 C/G cg24642439 chr20:33292090 TP53INP2 0.68 15.5 0.52 2.97e-46 Coronary artery disease; BRCA cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg12011299 chr4:100065546 ADH4 0.48 10.94 0.4 1.21e-25 Smoking initiation; BRCA cis rs4363385 0.747 rs6668215 chr1:152964498 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.25 -0.34 3.44e-19 Inflammatory skin disease; BRCA cis rs6565180 0.632 rs8050812 chr16:30385837 C/T cg17640201 chr16:30407289 ZNF48 -0.67 -13.51 -0.47 8.79e-37 Tonsillectomy; BRCA cis rs8072100 0.840 rs11079774 chr17:45479706 C/G cg08085267 chr17:45401833 C17orf57 -0.69 -15.2 -0.52 8.76e-45 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6840360 0.593 rs2089811 chr4:152685171 C/T cg22705602 chr4:152727874 NA 0.38 10.57 0.39 3.57e-24 Intelligence (multi-trait analysis); BRCA cis rs2439831 0.850 rs3736180 chr15:44106624 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.73 12.38 0.44 1.05e-31 Lung cancer in ever smokers; BRCA cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg11663144 chr21:46675770 NA -0.5 -10.03 -0.37 4.51e-22 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs501916 0.602 rs472081 chr15:48058652 G/T cg16110827 chr15:48056943 SEMA6D -0.42 -9.13 -0.34 9.06e-19 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs1577917 1.000 rs1911552 chr6:86638024 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.42 -11.54 -0.42 4.14e-28 Response to antipsychotic treatment; BRCA cis rs7833790 0.724 rs1054078 chr8:82712153 A/G cg27398817 chr8:82754497 SNX16 -0.37 -8.57 -0.32 7.68e-17 Diastolic blood pressure; BRCA cis rs11098499 0.863 rs1383533 chr4:120434576 G/A cg09307838 chr4:120376055 NA 0.7 14.24 0.49 3.67e-40 Corneal astigmatism; BRCA cis rs34779708 0.736 rs34195979 chr10:35549817 T/C cg03585969 chr10:35415529 CREM 0.43 8.71 0.33 2.56e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4820539 0.966 rs2283803 chr22:23454881 G/A cg14186256 chr22:23484241 RTDR1 0.76 22.75 0.67 2.33e-84 Bone mineral density; BRCA trans rs1005277 0.602 rs1780141 chr10:38504299 T/C cg17830980 chr10:43048298 ZNF37B -0.53 -12.81 -0.45 1.36e-33 Extrinsic epigenetic age acceleration; BRCA cis rs68170813 0.559 rs75007274 chr7:106814543 G/A cg02696742 chr7:106810147 HBP1 -0.54 -8.72 -0.33 2.4e-17 Coronary artery disease; BRCA trans rs35110281 0.713 rs1378079 chr21:45011187 A/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.15 0.31 1.96e-15 Mean corpuscular volume; BRCA cis rs9443645 0.505 rs9359364 chr6:79795992 G/A cg18132916 chr6:79620363 NA -0.4 -7.98 -0.3 6.92e-15 Intelligence (multi-trait analysis); BRCA cis rs17685 0.712 rs4732578 chr7:75721532 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.83 -0.33 9.91e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs3824867 0.920 rs7126210 chr11:47460306 A/G cg20307385 chr11:47447363 PSMC3 0.51 11.31 0.41 3.56e-27 Mean corpuscular hemoglobin; BRCA cis rs10779751 1.000 rs11121704 chr1:11293959 A/G cg08854313 chr1:11322531 MTOR -0.79 -16.59 -0.55 1.12e-51 Body mass index; BRCA trans rs2562456 0.958 rs2562508 chr19:21726281 G/A cg25042112 chr7:64838748 ZNF92 0.45 8.37 0.31 3.68e-16 Pain; BRCA cis rs11711311 1.000 rs28394480 chr3:113485143 T/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.14 0.4 1.9e-26 IgG glycosylation; BRCA cis rs2880765 0.743 rs6416598 chr15:86011848 G/A cg10818794 chr15:86012489 AKAP13 -0.31 -8.48 -0.32 1.59e-16 Coronary artery disease; BRCA cis rs34172651 0.517 rs11647120 chr16:24819806 A/G cg06028605 chr16:24865363 SLC5A11 0.43 9.68 0.36 8.76e-21 Intelligence (multi-trait analysis); BRCA cis rs9381040 0.655 rs2268188 chr6:41042590 T/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA trans rs6089829 0.926 rs6062395 chr20:61667904 A/G cg15934090 chr1:100435551 SLC35A3 0.35 8.11 0.31 2.6e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg13854012 chr2:162103682 NA -0.39 -8.7 -0.33 2.92e-17 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs11577318 0.853 rs4450008 chr1:26643860 C/A cg00852783 chr1:26633632 UBXN11 0.49 10.37 0.38 2.24e-23 Granulocyte percentage of myeloid white cells; BRCA cis rs10791097 0.765 rs4622274 chr11:130729486 C/T cg12179176 chr11:130786555 SNX19 0.62 14.51 0.5 1.95e-41 Autism spectrum disorder or schizophrenia;Schizophrenia; BRCA cis rs6121246 0.559 rs6060599 chr20:30257754 T/G cg13852791 chr20:30311386 BCL2L1 0.95 22.95 0.67 1.76e-85 Mean corpuscular hemoglobin; BRCA cis rs12142240 0.698 rs6690075 chr1:46819848 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.15 0.31 1.97e-15 Menopause (age at onset); BRCA cis rs17376456 0.877 rs10072592 chr5:93405989 C/G cg21475434 chr5:93447410 FAM172A 0.68 8.55 0.32 8.84e-17 Diabetic retinopathy; BRCA trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21659725 chr3:3221576 CRBN 0.5 12.87 0.45 7.57e-34 Intelligence (multi-trait analysis); BRCA cis rs791888 0.929 rs791887 chr10:89411554 A/G cg13926569 chr10:89418898 PAPSS2 -0.35 -8.03 -0.3 4.66e-15 Magnesium levels; BRCA cis rs6121246 0.609 rs1009453 chr20:30404840 C/G cg13852791 chr20:30311386 BCL2L1 0.84 18.04 0.58 3.93e-59 Mean corpuscular hemoglobin; BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg26516362 chr5:178986906 RUFY1 0.44 11.78 0.42 3.98e-29 Lung cancer; BRCA cis rs13046373 0.535 rs2832957 chr21:31973140 C/T cg22337977 chr21:31811175 KRTAP15-1 0.34 8.16 0.31 1.8e-15 HDL cholesterol; BRCA cis rs10504229 0.683 rs11775506 chr8:58133639 G/T cg11062466 chr8:58055876 NA 0.42 8.02 0.3 5.19e-15 Developmental language disorder (linguistic errors); BRCA cis rs78456975 0.622 rs11896517 chr2:1518112 A/G cg26248373 chr2:1572462 NA -0.49 -10.42 -0.38 1.41e-23 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9393692 0.645 rs28446029 chr6:26305801 C/G cg13736514 chr6:26305472 NA -0.46 -14.83 -0.51 5.92e-43 Educational attainment; BRCA cis rs2841277 0.645 rs28380382 chr14:105410827 C/T cg15352829 chr14:105391018 PLD4 -0.38 -12.35 -0.44 1.35e-31 Rheumatoid arthritis; BRCA trans rs208520 1.000 rs72880045 chr6:66965232 A/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.85 14.6 0.5 6.91e-42 Exhaled nitric oxide output; BRCA cis rs17376456 0.877 rs7736620 chr5:93305762 C/T cg25358565 chr5:93447407 FAM172A 1.14 18.39 0.59 6.32e-61 Diabetic retinopathy; BRCA cis rs495337 0.736 rs595777 chr20:48474819 C/G cg17835207 chr20:48524531 SPATA2 -0.5 -11.06 -0.4 3.87e-26 Psoriasis; BRCA cis rs1707322 1.000 rs6661500 chr1:46465662 T/C cg06784218 chr1:46089804 CCDC17 0.45 10.77 0.39 5.62e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9815354 0.812 rs11129935 chr3:41985203 A/C cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA trans rs561341 1.000 rs117979353 chr17:30272866 A/G cg20587970 chr11:113659929 NA -1.35 -24.23 -0.69 1.81e-92 Hip circumference adjusted for BMI; BRCA cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg05665937 chr4:1216051 CTBP1 0.52 11.3 0.41 4.08e-27 Obesity-related traits; BRCA trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21659725 chr3:3221576 CRBN 0.7 20.95 0.64 1.37e-74 Intelligence (multi-trait analysis); BRCA cis rs10752881 0.935 rs4652771 chr1:183023503 G/A ch.1.3577855R chr1:183094577 LAMC1 0.64 16.69 0.55 3.53e-52 Colorectal cancer; BRCA cis rs10256972 0.758 rs11979275 chr7:1069335 A/T cg07930192 chr7:1003750 NA 0.4 8.69 0.33 3.03e-17 Longevity;Endometriosis; BRCA cis rs2797160 1.000 rs1777194 chr6:126004883 G/A cg05901451 chr6:126070800 HEY2 -0.39 -9.42 -0.35 7.86e-20 Endometrial cancer; BRCA cis rs12541635 0.966 rs4734128 chr8:107026913 G/A cg10147462 chr8:107024639 NA 0.36 9.75 0.36 5.03e-21 Age of smoking initiation; BRCA trans rs2727020 1.000 rs2727020 chr11:49111407 C/G cg15704280 chr7:45808275 SEPT13 0.77 15.91 0.53 2.93e-48 Coronary artery disease; BRCA trans rs6951245 0.554 rs11544331 chr7:1131411 C/T cg13565492 chr6:43139072 SRF -0.87 -15.16 -0.51 1.39e-44 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2303759 0.515 rs2334867 chr19:49788205 C/T cg05022225 chr19:49866942 DKKL1;TEAD2 -0.37 -8.18 -0.31 1.49e-15 Multiple sclerosis; BRCA cis rs10504229 0.596 rs7004566 chr8:58115602 G/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.54e-15 Developmental language disorder (linguistic errors); BRCA cis rs877282 1.000 rs877281 chr10:771557 T/G cg17470449 chr10:769945 NA 0.5 8.88 0.33 6.84e-18 Uric acid levels; BRCA trans rs3733585 0.746 rs4318650 chr4:10016868 T/C cg26043149 chr18:55253948 FECH 0.36 7.81 0.3 2.29e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9427116 0.502 rs903323 chr1:154572228 A/G cg17218026 chr1:154582156 ADAR -0.27 -8.37 -0.31 3.56e-16 Blood protein levels; BRCA cis rs4665809 0.590 rs1865324 chr2:26417533 C/A cg25036284 chr2:26402008 FAM59B -0.89 -15.1 -0.51 2.72e-44 Gut microbiome composition (summer); BRCA cis rs7833790 0.700 rs7825180 chr8:82723991 T/A cg17211192 chr8:82754475 SNX16 -0.49 -11.16 -0.4 1.48e-26 Diastolic blood pressure; BRCA cis rs7044106 0.690 rs10739569 chr9:123361027 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.58 12.4 0.44 8.43e-32 Hip circumference adjusted for BMI; BRCA cis rs9611519 1.000 rs4820433 chr22:41607065 C/G cg03806693 chr22:41940476 POLR3H -0.42 -8.08 -0.3 3.27e-15 Neuroticism; BRCA cis rs8014204 0.816 rs28426374 chr14:75346740 C/T cg06637938 chr14:75390232 RPS6KL1 -0.41 -8.22 -0.31 1.14e-15 Caffeine consumption; BRCA cis rs10782582 0.609 rs1001160 chr1:76358591 A/C cg03433033 chr1:76189801 ACADM -0.38 -8.01 -0.3 5.62e-15 Daytime sleep phenotypes; BRCA trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg26384229 chr12:38710491 ALG10B 0.75 16.59 0.55 1.17e-51 Morning vs. evening chronotype; BRCA cis rs34779708 0.801 rs12098720 chr10:35538683 G/A cg03585969 chr10:35415529 CREM 0.45 9.22 0.34 4.14e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs17253792 0.822 rs45501402 chr14:56140115 C/T cg01858014 chr14:56050164 KTN1 -0.75 -9.37 -0.35 1.25e-19 Putamen volume; BRCA cis rs13118159 0.899 rs3796613 chr4:1353321 A/T cg20887711 chr4:1340912 KIAA1530 0.4 9.71 0.36 7.07e-21 Longevity; BRCA cis rs9733 0.596 rs3087960 chr1:150620569 C/G cg18016565 chr1:150552671 MCL1 0.35 8.29 0.31 6.92e-16 Tonsillectomy; BRCA cis rs3733585 0.699 rs62294332 chr4:9959989 T/C cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7246967 0.551 rs34907478 chr19:22928831 T/C cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs10504073 0.584 rs12546490 chr8:49932841 C/T cg00325661 chr8:49890786 NA 0.5 14.18 0.49 6.82e-40 Blood metabolite ratios; BRCA cis rs12701220 0.553 rs34062359 chr7:1139076 C/T cg02733842 chr7:1102375 C7orf50 -0.8 -13.59 -0.47 3.74e-37 Bronchopulmonary dysplasia; BRCA cis rs10870270 0.830 rs10781571 chr10:133774316 G/C cg08754478 chr10:133766260 PPP2R2D -0.69 -14.01 -0.48 4.52e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs12541635 0.966 rs62527363 chr8:107024258 A/G cg10147462 chr8:107024639 NA 0.37 10.37 0.38 2.09e-23 Age of smoking initiation; BRCA cis rs6740322 0.857 rs11690012 chr2:43542480 C/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -12.45 -0.44 5.24e-32 Coronary artery disease; BRCA cis rs4566357 0.595 rs10206912 chr2:227921095 A/T cg05526886 chr2:227700861 RHBDD1 -0.42 -8.66 -0.32 3.76e-17 Coronary artery disease; BRCA cis rs11123170 0.543 rs12472361 chr2:113980645 C/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.64 10.42 0.38 1.43e-23 Renal function-related traits (BUN); BRCA cis rs7249142 0.562 rs2239370 chr19:19292674 T/C cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.43 -9.28 -0.34 2.58e-19 IgG glycosylation; BRCA cis rs12474201 0.832 rs4953419 chr2:46989869 T/G cg06386533 chr2:46925753 SOCS5 0.84 18.37 0.59 8.21e-61 Height; BRCA trans rs10771431 0.782 rs10771415 chr12:9358223 C/T cg27600084 chr12:12264075 NA 0.35 8.19 0.31 1.44e-15 Breast size; BRCA cis rs7618915 0.501 rs13079063 chr3:52744460 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.16 0.4 1.48e-26 Bipolar disorder; BRCA cis rs8017423 0.608 rs12589866 chr14:90820977 T/C cg04374321 chr14:90722782 PSMC1 -0.5 -12.16 -0.43 9.29e-31 Mortality in heart failure; BRCA cis rs7246657 0.551 rs10407224 chr19:37651470 G/T cg18154014 chr19:37997991 ZNF793 0.53 8.62 0.32 5.35e-17 Coronary artery calcification; BRCA cis rs9287719 0.934 rs6432110 chr2:10738018 T/A cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs3733585 0.605 rs4697926 chr4:10124567 G/T cg00071950 chr4:10020882 SLC2A9 0.49 11.35 0.41 2.59e-27 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs4774830 0.744 rs2288346 chr15:56139153 T/C cg05129572 chr15:56138634 NEDD4 -0.6 -8.46 -0.32 1.76e-16 Delta-5 desaturase activity; BRCA cis rs6831352 0.879 rs29001229 chr4:100046823 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.75 -0.42 5.46e-29 Alcohol dependence; BRCA cis rs4363385 0.747 rs946097 chr1:152974732 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.54 -0.35 2.94e-20 Inflammatory skin disease; BRCA trans rs6828577 0.729 rs35604604 chr4:119421152 C/A cg26518628 chr1:97050305 NA -0.46 -9.48 -0.35 4.74e-20 Perioperative myocardial infarction in coronary artery bypass surgery; BRCA cis rs1153858 1.000 rs7163720 chr15:45639374 G/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.88 0.43 1.44e-29 Homoarginine levels; BRCA trans rs11098499 0.779 rs10011097 chr4:120310359 T/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs1577917 0.740 rs9353327 chr6:86394066 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.33 -9.01 -0.34 2.28e-18 Response to antipsychotic treatment; BRCA cis rs523522 0.962 rs11065149 chr12:120956963 G/A cg12219531 chr12:120966889 COQ5 0.55 11.44 0.41 1.11e-27 High light scatter reticulocyte count; BRCA cis rs6088813 1.000 rs6088816 chr20:33982435 G/A cg14752227 chr20:34000481 UQCC -0.41 -8.85 -0.33 8.21e-18 Height; BRCA cis rs11690935 0.589 rs62183782 chr2:172865009 T/A cg13550731 chr2:172543902 DYNC1I2 0.49 12.09 0.43 1.91e-30 Schizophrenia; BRCA cis rs17092148 0.945 rs6087622 chr20:33310471 A/G cg16810054 chr20:33298113 TP53INP2 -0.5 -11.3 -0.41 4.18e-27 Neuroticism; BRCA cis rs644799 1.000 rs474442 chr11:95583995 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.51 11.07 0.4 3.51e-26 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg07148914 chr20:33460835 GGT7 0.38 8.62 0.32 5.21e-17 Height; BRCA cis rs60871478 0.786 rs62432898 chr7:826102 G/A cg27478167 chr7:817139 HEATR2 -0.57 -11.58 -0.42 2.69e-28 Cerebrospinal P-tau181p levels; BRCA cis rs12612619 0.732 rs11687536 chr2:27199754 C/T cg00617064 chr2:27272375 NA 0.31 8.06 0.3 3.77e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs9297145 0.761 rs62473005 chr7:98742510 G/C cg05967295 chr7:98741636 SMURF1 0.95 17.22 0.56 6.85e-55 Crohn's disease;Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs7666738 0.830 rs2865951 chr4:99040191 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.6 0.55 9.62e-52 Colonoscopy-negative controls vs population controls; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg09436375 chr6:42928200 GNMT -0.3 -10.99 -0.4 7.31e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs977987 0.806 rs35263058 chr16:75391937 T/C cg03315344 chr16:75512273 CHST6 0.53 12.65 0.45 6.77e-33 Dupuytren's disease; BRCA cis rs965469 1.000 rs2236118 chr20:3302058 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -10.23 -0.37 7.84e-23 IFN-related cytopenia; BRCA cis rs10911251 0.528 rs2147584 chr1:183074764 T/C ch.1.3577855R chr1:183094577 LAMC1 0.68 17.94 0.58 1.39e-58 Colorectal cancer; BRCA cis rs2180341 0.722 rs9388555 chr6:127576363 G/A cg27446573 chr6:127587934 RNF146 0.78 17.43 0.57 5.9e-56 Breast cancer; BRCA cis rs9443645 0.803 rs12195716 chr6:79535412 T/C cg05283184 chr6:79620031 NA -0.45 -11.48 -0.41 7.5e-28 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs3755806 chr3:52643685 C/T cg18404041 chr3:52824283 ITIH1 0.43 12.79 0.45 1.56e-33 Bipolar disorder; BRCA cis rs1707322 0.721 rs4431884 chr1:46101323 C/T cg24296786 chr1:45957014 TESK2 -0.39 -8.13 -0.31 2.17e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11105298 0.786 rs10777186 chr12:89921277 G/A cg00757033 chr12:89920650 WDR51B 0.54 11.08 0.4 3.21e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs3815700 1.000 rs2287670 chr19:33095057 G/A cg02997394 chr19:33096574 ANKRD27 0.69 11.47 0.41 7.98e-28 Eosinophilic esophagitis; BRCA cis rs2742234 0.504 rs7093409 chr10:43740067 A/G cg02780029 chr10:43622663 RET 0.35 7.83 0.3 2.01e-14 Hirschsprung disease; BRCA cis rs514406 0.644 rs1855127 chr1:53199594 A/G cg24675658 chr1:53192096 ZYG11B 0.65 15.48 0.52 3.75e-46 Monocyte count; BRCA cis rs798554 0.757 rs2644312 chr7:2841164 G/A cg19717773 chr7:2847554 GNA12 -0.41 -7.97 -0.3 7.1e-15 Height; BRCA cis rs6121246 0.909 rs6089058 chr20:30326338 T/G cg13852791 chr20:30311386 BCL2L1 0.84 16.5 0.55 3.24e-51 Mean corpuscular hemoglobin; BRCA trans rs61931739 0.500 rs11053249 chr12:34518834 A/T cg13010199 chr12:38710504 ALG10B 0.51 10.0 0.37 5.91e-22 Morning vs. evening chronotype; BRCA cis rs4853036 0.629 rs13388084 chr2:70017663 C/T cg02498382 chr2:70120550 SNRNP27 -0.42 -7.87 -0.3 1.55e-14 Colorectal or endometrial cancer; BRCA trans rs61931739 0.500 rs11053197 chr12:34441949 C/T cg26384229 chr12:38710491 ALG10B 0.74 16.62 0.55 8.14e-52 Morning vs. evening chronotype; BRCA trans rs17685 0.535 rs6953065 chr7:75601169 A/G cg19862616 chr7:65841803 NCRNA00174 -0.37 -8.97 -0.33 3.29e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs12681287 0.547 rs6471360 chr8:87513469 C/T cg27223183 chr8:87520930 FAM82B 0.45 8.76 0.33 1.68e-17 Caudate activity during reward; BRCA cis rs67981189 0.574 rs2810118 chr14:71388575 A/G cg15816911 chr14:71606274 NA -0.37 -8.45 -0.32 2e-16 Schizophrenia; BRCA cis rs2249625 0.584 rs2463744 chr6:72875936 C/T cg18830697 chr6:72922368 RIMS1 -0.64 -14.66 -0.5 3.57e-42 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA trans rs11722228 0.508 rs73212864 chr4:10104191 G/A cg26043149 chr18:55253948 FECH 1.1 23.64 0.68 2.83e-89 Gout;Urate levels;Serum uric acid levels; BRCA cis rs10504229 0.683 rs11786074 chr8:58133532 A/G cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs11252926 0.528 rs11252090 chr10:436547 C/T cg00953403 chr17:74099816 EXOC7 -0.52 -9.73 -0.36 5.79e-21 Psychosis in Alzheimer's disease; BRCA cis rs8072100 0.701 rs8078309 chr17:45774072 T/C cg25173405 chr17:45401733 C17orf57 -0.49 -9.68 -0.36 9.34e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs2011503 0.943 rs10406278 chr19:19494725 A/C cg15839431 chr19:19639596 YJEFN3 0.41 9.14 0.34 8.24e-19 Bipolar disorder; BRCA cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg16414030 chr3:133502952 NA -0.47 -10.95 -0.4 1.12e-25 Iron status biomarkers; BRCA cis rs11608355 0.545 rs7969313 chr12:109907303 A/G cg05360138 chr12:110035743 NA 0.7 12.83 0.45 1.09e-33 Neuroticism; BRCA cis rs12142240 0.698 rs6695043 chr1:46844530 A/G cg14993813 chr1:46806288 NSUN4 0.47 9.22 0.34 4.1e-19 Menopause (age at onset); BRCA cis rs4689388 0.856 rs4308430 chr4:6294095 A/G cg00701064 chr4:6280414 WFS1 0.68 17.62 0.57 5.86e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs6089584 0.706 rs6089625 chr20:60620622 T/C cg13770153 chr20:60521292 NA -0.42 -9.27 -0.34 2.73e-19 Body mass index; BRCA cis rs9443645 0.901 rs2050660 chr6:79734726 C/T cg18132916 chr6:79620363 NA -0.49 -11.13 -0.4 1.95e-26 Intelligence (multi-trait analysis); BRCA cis rs9858542 1.000 rs6770670 chr3:49686682 T/C cg03060546 chr3:49711283 APEH -0.61 -12.39 -0.44 9.33e-32 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs910316 0.726 rs61979167 chr14:75663610 C/T cg23033748 chr14:75592666 NEK9 -0.36 -8.51 -0.32 1.21e-16 Height; BRCA cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg23711669 chr6:146136114 FBXO30 0.79 18.93 0.6 9.16e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs12579753 0.810 rs10862350 chr12:82156202 G/A cg07988820 chr12:82153109 PPFIA2 -0.44 -8.18 -0.31 1.54e-15 Resting heart rate; BRCA cis rs701145 0.585 rs1727944 chr3:153826603 A/C cg17054900 chr3:154042577 DHX36 -0.53 -9.06 -0.34 1.51e-18 Coronary artery disease; BRCA cis rs2505998 0.833 rs2565203 chr10:43603735 A/G cg15436174 chr10:43711423 RASGEF1A -0.44 -8.56 -0.32 8.21e-17 Hirschsprung disease; BRCA cis rs853679 0.542 rs9380063 chr6:28137853 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs7666738 0.887 rs34509663 chr4:98982531 C/T cg17366294 chr4:99064904 C4orf37 0.54 11.58 0.42 2.76e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs13046373 0.535 rs1354866 chr21:31981559 A/T cg16812893 chr21:31813075 KRTAP15-1 0.38 9.64 0.36 1.32e-20 HDL cholesterol; BRCA cis rs534126 0.744 rs10248147 chr7:142941023 C/G cg21852589 chr7:142981689 TMEM139 -0.43 -10.13 -0.37 1.84e-22 Cancer; BRCA cis rs7552404 0.627 rs12127049 chr1:76353248 G/A cg22875332 chr1:76189707 ACADM 0.62 11.47 0.41 7.96e-28 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.830 rs3846444 chr4:99032888 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs9467711 0.591 rs3752417 chr6:26045905 G/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.55 7.99 0.3 6.45e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs796364 0.760 rs2202922 chr2:200882610 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.66 10.4 0.38 1.6e-23 Schizophrenia; BRCA cis rs1843834 0.898 rs11887386 chr2:225526975 T/G cg22455342 chr2:225449267 CUL3 0.35 8.59 0.32 6.59e-17 IgE levels in asthmatics (D.p. specific); BRCA cis rs13191362 0.935 rs13219926 chr6:163004213 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.12 0.43 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs61931739 0.534 rs4365131 chr12:34053308 T/C cg26384229 chr12:38710491 ALG10B 0.57 12.2 0.43 6.52e-31 Morning vs. evening chronotype; BRCA cis rs9291683 0.507 rs6827754 chr4:10018153 A/C cg11266682 chr4:10021025 SLC2A9 -0.44 -11.66 -0.42 1.34e-28 Bone mineral density; BRCA cis rs2243480 1.000 rs419603 chr7:65597341 C/T cg18252515 chr7:66147081 NA -1.07 -15.7 -0.53 3.09e-47 Diabetic kidney disease; BRCA trans rs10028773 0.506 rs12374346 chr4:120281705 G/A cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Educational attainment; BRCA cis rs875971 0.862 rs10250544 chr7:65766561 A/G cg18876405 chr7:65276391 NA -0.5 -11.14 -0.4 1.82e-26 Aortic root size; BRCA cis rs17401966 0.838 rs35759975 chr1:10474430 A/T cg19773385 chr1:10388646 KIF1B -0.37 -7.97 -0.3 7.1e-15 Hepatocellular carcinoma; BRCA cis rs12310956 0.532 rs1525897 chr12:33941033 C/T cg06521331 chr12:34319734 NA -0.61 -11.15 -0.4 1.73e-26 Morning vs. evening chronotype; BRCA cis rs1953600 0.870 rs2573353 chr10:81940917 A/C cg04850286 chr10:81895943 PLAC9 -0.31 -8.94 -0.33 4e-18 Sarcoidosis; BRCA cis rs3806843 1.000 rs10073974 chr5:140165231 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.77 -0.36 4.22e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs12310956 0.532 rs1589902 chr12:33989289 G/A cg26384229 chr12:38710491 ALG10B 0.51 11.03 0.4 4.98e-26 Morning vs. evening chronotype; BRCA cis rs372883 0.600 rs407712 chr21:30722531 G/A cg08807101 chr21:30365312 RNF160 -0.44 -9.35 -0.35 1.42e-19 Pancreatic cancer; BRCA cis rs8038465 0.615 rs62004616 chr15:73961176 C/T cg15420318 chr15:73925796 NPTN 0.41 9.16 0.34 7.03e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs3780486 0.505 rs1411609 chr9:33137303 C/T cg20290983 chr6:43655470 MRPS18A 0.82 22.18 0.66 2.91e-81 IgG glycosylation; BRCA cis rs9921222 0.565 rs10903014 chr16:377623 A/G cg00101154 chr16:420108 MRPL28 -0.45 -10.56 -0.39 4.02e-24 Bone mineral density (spine);Bone mineral density; BRCA cis rs875971 0.862 rs1983372 chr7:65611351 C/T cg18876405 chr7:65276391 NA -0.51 -11.86 -0.42 1.77e-29 Aortic root size; BRCA cis rs1862618 0.802 rs986049 chr5:56110233 G/A cg18230493 chr5:56204884 C5orf35 -0.74 -14.89 -0.51 2.85e-43 Initial pursuit acceleration; BRCA cis rs10504229 1.000 rs58053450 chr8:58173348 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs8072100 0.967 rs3760370 chr17:45695832 C/T cg19784903 chr17:45786737 TBKBP1 0.34 8.15 0.31 1.86e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs595982 0.527 rs56021835 chr19:49369989 G/A cg21252483 chr19:49399788 TULP2 -0.41 -9.26 -0.34 3.11e-19 Red cell distribution width; BRCA cis rs1865760 0.516 rs10807007 chr6:26048931 A/C cg17691542 chr6:26056736 HIST1H1C 0.53 11.44 0.41 1.05e-27 Height; BRCA cis rs1997103 1.000 rs6948112 chr7:55411302 G/A cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2777491 0.957 rs7163788 chr15:41704789 A/G cg18705301 chr15:41695430 NDUFAF1 -0.67 -16.41 -0.54 9.66e-51 Ulcerative colitis; BRCA cis rs7786877 0.521 rs2293767 chr7:100361675 A/G cg20848291 chr7:100343083 ZAN 0.46 10.13 0.37 1.81e-22 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs7267979 0.833 rs6138556 chr20:25243310 C/T cg08601574 chr20:25228251 PYGB 0.41 9.54 0.35 2.85e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs832540 0.931 rs2591960 chr5:56238811 A/T cg18230493 chr5:56204884 C5orf35 0.55 11.07 0.4 3.47e-26 Coronary artery disease; BRCA cis rs921968 0.573 rs684776 chr2:219324016 T/C cg10223061 chr2:219282414 VIL1 -0.27 -7.89 -0.3 1.36e-14 Mean corpuscular hemoglobin concentration; BRCA cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg17420585 chr12:42539391 GXYLT1 -0.38 -8.12 -0.31 2.35e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1218582 0.711 rs4845677 chr1:154838050 C/T cg09359103 chr1:154839909 KCNN3 -0.58 -15.09 -0.51 3.28e-44 Prostate cancer; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg22907277 chr7:1156413 C7orf50 0.59 9.1 0.34 1.11e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs4323111 chr4:98952276 A/G cg05340658 chr4:99064831 C4orf37 0.66 16.14 0.54 2.18e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs2836950 0.545 rs4818001 chr21:40575088 T/C cg11644478 chr21:40555479 PSMG1 -0.55 -11.79 -0.42 3.59e-29 Menarche (age at onset); BRCA cis rs13256369 1.000 rs883648 chr8:8569521 A/G cg18904891 chr8:8559673 CLDN23 0.63 12.34 0.44 1.55e-31 Obesity-related traits; BRCA cis rs1035491 0.574 rs10461497 chr5:63942398 A/G cg01791865 chr5:63954708 NA 0.33 8.44 0.32 2.16e-16 Body mass index; BRCA cis rs10911232 0.507 rs10911206 chr1:183012423 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.92 0.56 2.52e-53 Hypertriglyceridemia; BRCA cis rs6723226 0.521 rs1991626 chr2:32602450 G/A cg02381751 chr2:32503542 YIPF4 -0.46 -9.49 -0.35 4.64e-20 Intelligence (multi-trait analysis); BRCA cis rs12042938 1.000 rs4366301 chr1:231806286 C/G cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.37 -8.16 -0.31 1.84e-15 Neuranatomic and neurocognitive phenotypes; BRCA cis rs270601 0.913 rs273899 chr5:131695178 G/A cg07395648 chr5:131743802 NA -0.37 -7.95 -0.3 8.72e-15 Acylcarnitine levels; BRCA cis rs877282 0.945 rs11253388 chr10:787852 A/G cg17470449 chr10:769945 NA 0.51 8.63 0.32 4.87e-17 Uric acid levels; BRCA cis rs7927771 1.000 rs9909 chr11:47799775 C/G cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 1e-15 Subjective well-being; BRCA cis rs72781680 0.611 rs7596060 chr2:24334361 A/G cg06627628 chr2:24431161 ITSN2 0.51 8.22 0.31 1.11e-15 Lymphocyte counts; BRCA cis rs193541 0.632 rs2910135 chr5:122229790 C/T cg19412675 chr5:122181750 SNX24 0.33 7.9 0.3 1.2e-14 Glucose homeostasis traits; BRCA cis rs6904897 0.563 rs4896117 chr6:135229400 T/C cg24558204 chr6:135376177 HBS1L -0.42 -10.93 -0.4 1.32e-25 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA trans rs9858542 0.953 rs7622302 chr3:49547561 T/C cg21659725 chr3:3221576 CRBN -0.45 -9.61 -0.36 1.69e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs4908768 0.501 rs11121186 chr1:8540341 G/A cg20416874 chr1:8611966 RERE -0.27 -7.97 -0.3 7.25e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs495337 0.736 rs627898 chr20:48480254 A/C cg17835207 chr20:48524531 SPATA2 -0.5 -11.0 -0.4 6.92e-26 Psoriasis; BRCA cis rs1707322 1.000 rs785497 chr1:46591903 G/C cg06784218 chr1:46089804 CCDC17 -0.47 -10.55 -0.39 4.12e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7258465 0.931 rs1560119 chr19:18573675 A/G cg01065977 chr19:18549689 ISYNA1 -0.29 -8.46 -0.32 1.86e-16 Breast cancer; BRCA cis rs9790314 0.871 rs336551 chr3:161109720 T/C cg04691961 chr3:161091175 C3orf57 -0.47 -11.15 -0.4 1.72e-26 Morning vs. evening chronotype; BRCA cis rs9814567 0.964 rs1534028 chr3:134284639 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3857536 0.706 rs7755994 chr6:66891747 T/C cg07460842 chr6:66804631 NA -0.46 -8.86 -0.33 8.14e-18 Blood trace element (Cu levels); BRCA cis rs10129255 0.518 rs8009612 chr14:107185749 G/T cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.43e-17 Kawasaki disease; BRCA cis rs4363385 0.818 rs10888525 chr1:153000215 G/A cg24667326 chr1:152973720 SPRR3 -0.33 -9.01 -0.34 2.29e-18 Inflammatory skin disease; BRCA cis rs7666738 0.830 rs2865978 chr4:99017946 G/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs8044868 0.586 rs7200854 chr16:72083318 G/A cg16558253 chr16:72132732 DHX38 -0.45 -10.76 -0.39 6.27e-25 Body mass index (change over time) in cancer or chronic obstructive pulmonary disease;Body mass index (change over time) in cancer; BRCA cis rs4671400 0.571 rs28480287 chr2:61489289 G/C cg15711740 chr2:61764176 XPO1 0.39 7.9 0.3 1.21e-14 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs2721195 0.654 rs4610795 chr8:145881333 C/T cg15857475 chr8:145742913 RECQL4;LRRC14 -0.55 -12.74 -0.45 2.65e-33 Age at first birth; BRCA cis rs6570726 0.791 rs9376953 chr6:145912226 G/T cg23711669 chr6:146136114 FBXO30 0.79 18.95 0.6 6.68e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs7131987 0.801 rs6487804 chr12:29454934 G/A cg09582351 chr12:29534625 ERGIC2 -0.46 -11.03 -0.4 5.22e-26 QT interval; BRCA cis rs9486719 1.000 rs12205728 chr6:96891838 T/C cg06623918 chr6:96969491 KIAA0776 -0.72 -13.0 -0.46 1.92e-34 Migraine;Coronary artery disease; BRCA cis rs929596 0.556 rs10202865 chr2:234587707 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.37 -9.07 -0.34 1.51e-18 Total bilirubin levels in HIV-1 infection; BRCA cis rs2204008 0.547 rs12318267 chr12:38250905 T/G cg26384229 chr12:38710491 ALG10B -0.44 -10.07 -0.37 3.11e-22 Bladder cancer; BRCA cis rs490234 0.588 rs35278449 chr9:128172963 C/G cg14078157 chr9:128172775 NA -0.55 -12.03 -0.43 3.54e-30 Mean arterial pressure; BRCA cis rs2832191 0.967 rs2832216 chr21:30521921 C/T cg08807101 chr21:30365312 RNF160 0.52 12.92 0.46 4.15e-34 Dental caries; BRCA cis rs586533 0.881 rs612614 chr11:99504950 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.12 0.31 2.44e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs953387 1.000 rs12616955 chr2:136902666 C/T cg05194412 chr2:137003533 NA -0.37 -8.51 -0.32 1.26e-16 Arthritis (juvenile idiopathic); BRCA cis rs6582630 0.513 rs1596446 chr12:38282160 C/T cg13010199 chr12:38710504 ALG10B -0.4 -8.36 -0.31 3.94e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs780096 0.527 rs59644396 chr2:27646083 A/G cg17158414 chr2:27665306 KRTCAP3 -0.34 -8.69 -0.33 3.1e-17 Total body bone mineral density; BRCA cis rs1707322 0.716 rs10890342 chr1:46157087 C/T cg03146154 chr1:46216737 IPP 0.52 11.61 0.42 2.16e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2762353 0.935 rs1165215 chr6:25798932 G/A cg12310025 chr6:25882481 NA -0.5 -11.91 -0.43 1.13e-29 Blood metabolite levels; BRCA cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg18876405 chr7:65276391 NA -0.67 -16.99 -0.56 1.04e-53 Aortic root size; BRCA cis rs4363385 0.747 rs1415960 chr1:152973571 G/T cg25856811 chr1:152973957 SPRR3 -0.35 -9.27 -0.34 2.84e-19 Inflammatory skin disease; BRCA cis rs8114671 0.836 rs2038504 chr20:33648187 T/C cg07148914 chr20:33460835 GGT7 -0.42 -9.1 -0.34 1.16e-18 Height; BRCA cis rs10870270 0.784 rs10430614 chr10:133748640 C/T cg17892150 chr10:133769511 PPP2R2D 0.66 14.42 0.5 5.19e-41 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs2439831 1.000 rs9920763 chr15:43760508 T/G cg02155558 chr15:43621948 ADAL;LCMT2 0.81 13.29 0.47 9.64e-36 Lung cancer in ever smokers; BRCA cis rs2070488 1.000 rs7373816 chr3:38490443 C/A cg24069376 chr3:38537580 EXOG 0.41 11.96 0.43 6.63e-30 Electrocardiographic conduction measures; BRCA cis rs10197940 0.624 rs6731486 chr2:152410732 C/T cg19508488 chr2:152266495 RIF1 -0.49 -10.48 -0.38 7.71e-24 Lung cancer; BRCA cis rs11098499 0.909 rs1546502 chr4:120235898 A/G cg09307838 chr4:120376055 NA 0.7 14.57 0.5 9.78e-42 Corneal astigmatism; BRCA trans rs7618501 0.602 rs9311446 chr3:50092226 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.5 -0.35 4.15e-20 Intelligence (multi-trait analysis); BRCA cis rs2576037 0.526 rs1789152 chr18:44433092 G/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.53 11.89 0.43 1.4e-29 Personality dimensions; BRCA cis rs6088580 0.570 rs6058057 chr20:33065283 G/A cg24642439 chr20:33292090 TP53INP2 0.54 11.61 0.42 2e-28 Glomerular filtration rate (creatinine); BRCA cis rs561341 1.000 rs508192 chr17:30315147 C/T cg12193833 chr17:30244370 NA 0.51 8.41 0.32 2.64e-16 Hip circumference adjusted for BMI; BRCA cis rs17406451 0.587 rs6544646 chr2:43576997 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.41 -8.84 -0.33 9.29e-18 Mitochondrial DNA levels; BRCA cis rs7677751 0.806 rs7681399 chr4:55090886 T/G cg17187183 chr4:55093834 PDGFRA 0.44 9.14 0.34 7.9e-19 Corneal astigmatism; BRCA cis rs9467773 0.620 rs2451744 chr6:26633463 G/T cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA cis rs28735056 0.967 rs623546 chr18:77595228 C/T cg20368463 chr18:77673604 PQLC1 -0.34 -7.97 -0.3 7.21e-15 Schizophrenia; BRCA cis rs6539267 0.741 rs7314289 chr12:106686260 A/C cg00173435 chr12:106696525 TCP11L2 0.55 9.75 0.36 4.89e-21 Tourette syndrome; BRCA cis rs919433 0.713 rs6714697 chr2:198484486 C/T cg00792783 chr2:198669748 PLCL1 0.35 8.16 0.31 1.82e-15 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs7552404 0.696 rs67487205 chr1:76373756 T/C cg22875332 chr1:76189707 ACADM 0.64 11.42 0.41 1.32e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4665809 0.590 rs1049987 chr2:26413817 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.59 10.15 0.37 1.51e-22 Gut microbiome composition (summer); BRCA cis rs4363385 0.818 rs532743 chr1:153011758 T/G cg25856811 chr1:152973957 SPRR3 -0.33 -8.56 -0.32 8.51e-17 Inflammatory skin disease; BRCA cis rs2153535 0.580 rs9328484 chr6:8524843 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.38 0.49 7.79e-41 Motion sickness; BRCA cis rs4363385 0.747 rs1413849 chr1:152970233 C/A cg21543102 chr1:152974771 SPRR3 -0.29 -8.06 -0.3 3.69e-15 Inflammatory skin disease; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg22903471 chr2:27725779 GCKR -0.38 -9.22 -0.34 4.15e-19 Total body bone mineral density; BRCA cis rs9457247 0.534 rs9356551 chr6:167400345 T/C cg23791538 chr6:167370224 RNASET2 0.49 12.5 0.44 3.14e-32 Crohn's disease; BRCA cis rs939658 0.967 rs7171067 chr15:79452727 G/T cg17916960 chr15:79447300 NA 0.42 10.48 0.38 7.75e-24 Refractive error; BRCA trans rs60843830 1.000 rs56321614 chr2:268191 G/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.61 13.75 0.48 7.14e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs62064224 0.714 rs4794915 chr17:30634363 A/G cg25809561 chr17:30822961 MYO1D -0.4 -9.52 -0.35 3.52e-20 Schizophrenia; BRCA cis rs514406 0.893 rs512723 chr1:53343880 C/T cg25767906 chr1:53392781 SCP2 0.39 8.18 0.31 1.58e-15 Monocyte count; BRCA cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.5 -0.38 6.85e-24 Personality dimensions; BRCA cis rs4919694 1.000 rs12245343 chr10:104774050 A/G cg04362960 chr10:104952993 NT5C2 0.94 14.57 0.5 1.05e-41 Arsenic metabolism; BRCA cis rs4147929 0.532 rs4147932 chr19:1064485 C/T cg05372495 chr19:1063624 ABCA7 -0.42 -8.71 -0.33 2.61e-17 Alzheimer's disease (late onset); BRCA trans rs1005277 0.579 rs932538 chr10:38381314 T/C cg17830980 chr10:43048298 ZNF37B -0.54 -13.03 -0.46 1.32e-34 Extrinsic epigenetic age acceleration; BRCA cis rs2836950 0.565 rs2836942 chr21:40591381 A/G cg17971929 chr21:40555470 PSMG1 -0.49 -10.92 -0.4 1.48e-25 Menarche (age at onset); BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg14820908 chr5:178986412 RUFY1 -0.34 -8.54 -0.32 9.6e-17 Lung cancer; BRCA cis rs1862618 0.853 rs861283 chr5:56184610 C/T cg24531977 chr5:56204891 C5orf35 -0.86 -17.83 -0.58 4.82e-58 Initial pursuit acceleration; BRCA cis rs78456975 1.000 rs111935361 chr2:1554192 C/A cg01028140 chr2:1542097 TPO -0.81 -15.85 -0.53 5.82e-48 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg08280861 chr8:58055591 NA 0.56 9.09 0.34 1.21e-18 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.863 rs1480939 chr4:120456927 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.36 8.25 0.31 9.3e-16 Corneal astigmatism; BRCA cis rs694739 0.726 rs516124 chr11:64128423 G/T cg23796481 chr11:64053134 BAD;GPR137 0.49 10.26 0.38 5.58e-23 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA trans rs7824557 0.547 rs2409745 chr8:11076635 G/T cg15556689 chr8:8085844 FLJ10661 0.45 11.55 0.42 3.88e-28 Retinal vascular caliber; BRCA cis rs2836974 0.932 rs6517526 chr21:40581530 T/C cg11644478 chr21:40555479 PSMG1 0.85 19.35 0.61 5.16e-66 Cognitive function; BRCA cis rs1506636 0.720 rs2456552 chr7:123441400 A/G cg03229431 chr7:123269106 ASB15 0.41 9.68 0.36 8.66e-21 Plateletcrit;Platelet count; BRCA cis rs1707322 0.627 rs3014213 chr1:46045522 T/C cg06784218 chr1:46089804 CCDC17 -0.52 -12.34 -0.44 1.49e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1801251 0.964 rs6748027 chr2:233629552 T/C cg25237894 chr2:233734115 C2orf82 0.39 11.32 0.41 3.5e-27 Coronary artery disease; BRCA trans rs9329221 0.592 rs7832708 chr8:10190040 C/T cg06636001 chr8:8085503 FLJ10661 0.54 11.64 0.42 1.51e-28 Neuroticism; BRCA cis rs7267979 1.000 rs1046073 chr20:25281333 G/A cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.63e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4665809 1.000 rs4665306 chr2:26319124 C/T cg04944784 chr2:26401820 FAM59B -0.69 -11.44 -0.41 1.08e-27 Gut microbiome composition (summer); BRCA cis rs35146811 0.735 rs858506 chr7:99820050 T/C cg22906224 chr7:99728672 NA -0.43 -8.04 -0.3 4.29e-15 Coronary artery disease; BRCA cis rs7766436 0.885 rs1418311 chr6:22594964 T/G cg13666174 chr6:22585274 NA -0.49 -11.49 -0.41 6.42e-28 Coronary artery disease; BRCA cis rs2153535 0.542 rs6905925 chr6:8440030 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.73e-18 Motion sickness; BRCA cis rs796364 0.662 rs11687313 chr2:201146399 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -8.07 -0.3 3.51e-15 Schizophrenia; BRCA cis rs7903847 0.642 rs11814021 chr10:99158386 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.74 -0.33 2.09e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs875971 0.540 rs1723268 chr7:65473080 A/C cg18876405 chr7:65276391 NA 0.7 18.33 0.59 1.2e-60 Aortic root size; BRCA cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs1862618 0.853 rs252921 chr5:56137787 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -19.02 -0.6 2.94e-64 Initial pursuit acceleration; BRCA cis rs4727027 0.933 rs34578816 chr7:148847606 G/A cg23583168 chr7:148888333 NA -0.84 -19.93 -0.62 4.16e-69 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4563143 0.675 rs56322221 chr19:29270349 A/T cg12667521 chr19:29218732 NA 0.47 8.75 0.33 1.93e-17 Methadone dose in opioid dependence; BRCA cis rs4819052 1.000 rs2838847 chr21:46670958 G/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.72 15.14 0.51 1.89e-44 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1018836 0.828 rs12548806 chr8:91564256 C/T cg16814680 chr8:91681699 NA -0.59 -12.7 -0.45 4.24e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs9467773 1.000 rs9357010 chr6:26527945 C/G cg11502198 chr6:26597334 ABT1 0.49 9.89 0.36 1.5e-21 Intelligence (multi-trait analysis); BRCA cis rs1635 0.655 rs73742541 chr6:28310615 T/C cg15743358 chr6:28303923 ZNF323 -0.76 -8.85 -0.33 8.47e-18 Schizophrenia; BRCA cis rs1997103 1.000 rs6593233 chr7:55406200 C/T cg17469321 chr7:55412551 NA -0.5 -9.63 -0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg08470875 chr2:26401718 FAM59B -0.72 -12.01 -0.43 4.01e-30 Gut microbiome composition (summer); BRCA cis rs78456975 1.000 rs6712176 chr2:1556393 C/T cg12573674 chr2:1569213 NA -0.49 -9.28 -0.34 2.57e-19 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs208520 1.000 rs72882102 chr6:66983408 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.49 0.5 2.5e-41 Exhaled nitric oxide output; BRCA cis rs10504229 0.639 rs2318146 chr8:58114873 T/G cg08219700 chr8:58056026 NA 0.45 8.1 0.31 2.86e-15 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.953 rs72652908 chr8:58191324 G/A cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs7662987 0.517 rs2602858 chr4:100030461 T/C cg13256891 chr4:100009986 ADH5 0.53 9.76 0.36 4.38e-21 Smoking initiation; BRCA cis rs9868809 0.505 rs28567949 chr3:48744560 G/A cg07636037 chr3:49044803 WDR6 -0.58 -8.06 -0.3 3.81e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs17604090 0.887 rs7795109 chr7:29666244 G/A cg19413766 chr7:29689036 LOC646762 -0.52 -8.12 -0.31 2.32e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs501916 0.761 rs589889 chr15:48019016 C/G cg16110827 chr15:48056943 SEMA6D -0.39 -8.6 -0.32 6.08e-17 Inflammatory bowel disease;Ulcerative colitis; BRCA cis rs6964587 0.839 rs12536702 chr7:91471576 G/C cg17063962 chr7:91808500 NA 0.5 11.72 0.42 6.9e-29 Breast cancer; BRCA cis rs12711979 0.765 rs13028529 chr2:3825467 C/T cg17052675 chr2:3827356 NA -0.47 -13.98 -0.48 6.28e-39 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs875971 0.862 rs10274883 chr7:66116091 C/T cg18876405 chr7:65276391 NA -0.49 -10.78 -0.39 5.16e-25 Aortic root size; BRCA trans rs9944715 0.911 rs12969147 chr18:43806524 G/A cg01718231 chr17:29326311 RNF135 -0.4 -8.09 -0.3 3.1e-15 Red cell distribution width;Mean corpuscular volume; BRCA cis rs6952808 0.630 rs4719443 chr7:2161099 A/G cg05863683 chr7:1912471 MAD1L1 0.38 8.02 0.3 5.08e-15 Bipolar disorder and schizophrenia; BRCA cis rs2228479 0.764 rs7184960 chr16:89961661 C/T cg00800038 chr16:89945340 TCF25 -0.71 -10.85 -0.39 2.82e-25 Skin colour saturation; BRCA cis rs7523050 0.730 rs12726126 chr1:109436128 A/G cg08274380 chr1:109419600 GPSM2 1.18 16.83 0.55 6.67e-53 Fat distribution (HIV); BRCA cis rs751728 0.605 rs1535950 chr6:33785827 A/G cg25922239 chr6:33757077 LEMD2 0.43 9.78 0.36 3.97e-21 Crohn's disease; BRCA cis rs12142240 0.698 rs66847432 chr1:46832013 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.7 0.36 7.74e-21 Menopause (age at onset); BRCA cis rs6840360 0.571 rs4696279 chr4:152560449 G/A cg22705602 chr4:152727874 NA -0.33 -8.32 -0.31 5.25e-16 Intelligence (multi-trait analysis); BRCA cis rs1018836 0.923 rs6986689 chr8:91626709 A/C cg16814680 chr8:91681699 NA -0.6 -12.78 -0.45 1.84e-33 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs4862750 0.832 rs6419953 chr4:187900509 T/A cg10295955 chr4:187884368 NA -0.99 -32.04 -0.79 4.48e-135 Lobe attachment (rater-scored or self-reported); BRCA cis rs11190604 1.000 rs10509744 chr10:102271579 C/T cg07080220 chr10:102295463 HIF1AN 0.61 14.23 0.49 4.12e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4944092 0.793 rs94111 chr11:75915139 A/G cg04588336 chr11:75916460 WNT11 -0.54 -13.66 -0.48 1.94e-37 PR interval; BRCA cis rs586533 0.801 rs651048 chr11:99496234 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.0 0.3 5.88e-15 Depressive symptoms (multi-trait analysis); BRCA trans rs7746199 0.736 rs34064842 chr6:27688625 G/T cg01620082 chr3:125678407 NA -0.86 -9.95 -0.37 8.92e-22 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs2842992 0.747 rs1547093 chr6:160205991 C/A cg11366901 chr6:160182831 ACAT2 0.82 16.14 0.54 2.12e-49 Age-related macular degeneration (geographic atrophy); BRCA trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.32 -9.0 -0.34 2.62e-18 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg03188948 chr7:1209495 NA 0.55 10.48 0.38 7.88e-24 Longevity;Endometriosis; BRCA cis rs1552244 1.000 rs6764068 chr3:10153842 A/G cg00149659 chr3:10157352 C3orf10 0.81 14.21 0.49 5.29e-40 Alzheimer's disease; BRCA cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg15395560 chr15:45543142 SLC28A2 -0.3 -7.85 -0.3 1.79e-14 Uric acid levels; BRCA cis rs9790314 1.000 rs9850455 chr3:161017192 G/A cg03342759 chr3:160939853 NMD3 -0.65 -14.94 -0.51 1.73e-43 Morning vs. evening chronotype; BRCA cis rs2637266 0.935 rs2583058 chr10:78396018 T/A cg18941641 chr10:78392320 NA 0.38 8.67 0.32 3.69e-17 Pulmonary function; BRCA cis rs7618915 0.501 rs34754793 chr3:52629177 A/T cg18404041 chr3:52824283 ITIH1 -0.38 -11.76 -0.42 5.03e-29 Bipolar disorder; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg21747090 chr2:27597821 SNX17 -0.43 -9.31 -0.35 2.1e-19 Total body bone mineral density; BRCA cis rs6964587 0.626 rs7807765 chr7:91531974 C/A cg17063962 chr7:91808500 NA -0.55 -12.68 -0.45 5.25e-33 Breast cancer; BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.0 17.2 0.56 9.22e-55 Platelet count; BRCA cis rs1707322 0.721 rs4415615 chr1:46132109 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1005277 0.579 rs11011461 chr10:38431427 G/A cg23533926 chr12:111358616 MYL2 -0.41 -8.51 -0.32 1.2e-16 Extrinsic epigenetic age acceleration; BRCA cis rs9473147 0.543 rs9349407 chr6:47453378 C/G cg12968598 chr6:47444699 CD2AP 0.46 9.76 0.36 4.54e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs4665809 1.000 rs4233708 chr2:26291345 C/T cg27170947 chr2:26402098 FAM59B -0.66 -11.39 -0.41 1.75e-27 Gut microbiome composition (summer); BRCA cis rs7613875 0.580 rs2624819 chr3:50010571 G/T cg24110177 chr3:50126178 RBM5 -0.54 -16.05 -0.54 5.57e-49 Body mass index; BRCA cis rs13161895 1.000 rs12656814 chr5:179471556 G/A cg02702477 chr5:179499311 RNF130 0.46 8.53 0.32 1.03e-16 LDL cholesterol; BRCA cis rs778371 1.000 rs11535 chr2:233743532 G/C cg08000102 chr2:233561755 GIGYF2 -0.78 -17.25 -0.56 4.95e-55 Schizophrenia; BRCA cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg09184832 chr6:79620586 NA -0.51 -11.2 -0.4 1.09e-26 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.82 14.52 0.5 1.73e-41 Platelet count; BRCA cis rs8177253 0.665 rs9831392 chr3:133451473 A/T cg01448562 chr3:133502909 NA -0.41 -9.41 -0.35 9.13e-20 Iron status biomarkers; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.03 -18.48 -0.59 2e-61 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs61931739 0.534 rs4365131 chr12:34053308 T/C cg13010199 chr12:38710504 ALG10B 0.4 8.11 0.31 2.66e-15 Morning vs. evening chronotype; BRCA cis rs11764590 0.724 rs55789728 chr7:2107649 A/G cg23422044 chr7:1970798 MAD1L1 -0.44 -9.01 -0.34 2.4e-18 Neuroticism; BRCA cis rs2033711 0.837 rs3764535 chr19:58929052 G/A cg00825309 chr19:58991885 ZNF446 -0.58 -12.95 -0.46 3.25e-34 Uric acid clearance; BRCA cis rs10751667 0.666 rs6597960 chr11:977036 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA cis rs1355223 0.583 rs1396880 chr11:34870552 C/T cg24088639 chr11:34937564 PDHX;APIP 0.4 9.23 0.34 4.05e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs757110 0.745 rs2074311 chr11:17421860 A/G cg04705435 chr11:17411270 KCNJ11 0.45 10.15 0.37 1.54e-22 Type 2 diabetes; BRCA cis rs6450176 1.000 rs6886510 chr5:53303127 A/G ch.5.1024479R chr5:53302184 ARL15 0.6 14.59 0.5 8.3e-42 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs12541635 1.000 rs1896918 chr8:107090500 G/A cg10147462 chr8:107024639 NA -0.3 -8.29 -0.31 6.64e-16 Age of smoking initiation; BRCA cis rs1005277 0.557 rs2983338 chr10:38550734 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.23 -0.41 7.94e-27 Extrinsic epigenetic age acceleration; BRCA cis rs7662987 0.517 rs2602882 chr4:100040765 C/T cg12011299 chr4:100065546 ADH4 0.49 10.95 0.4 1.12e-25 Smoking initiation; BRCA cis rs34779708 0.931 rs17583009 chr10:35320915 T/C cg03585969 chr10:35415529 CREM 0.55 11.39 0.41 1.72e-27 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6964587 0.967 rs13233496 chr7:91813035 T/C cg22117172 chr7:91764530 CYP51A1 0.24 8.2 0.31 1.29e-15 Breast cancer; BRCA cis rs9463078 0.547 rs9472336 chr6:44710392 G/A cg25276700 chr6:44698697 NA 0.36 8.18 0.31 1.56e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg27478167 chr7:817139 HEATR2 -0.55 -11.03 -0.4 5.31e-26 Cerebrospinal P-tau181p levels; BRCA cis rs35306767 0.668 rs35657988 chr10:1103590 A/G cg20503657 chr10:835505 NA 0.61 10.08 0.37 2.78e-22 Eosinophil percentage of granulocytes; BRCA cis rs6582630 0.519 rs11609739 chr12:38547969 G/A cg13010199 chr12:38710504 ALG10B 0.52 10.55 0.39 4.1e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs4363385 0.747 rs2339495 chr1:152975116 A/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.32 -0.31 5.23e-16 Inflammatory skin disease; BRCA cis rs13082711 0.555 rs7627508 chr3:27252495 A/C cg02860705 chr3:27208620 NA 0.58 11.76 0.42 4.86e-29 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg07395648 chr5:131743802 NA 0.35 7.94 0.3 9.19e-15 Blood metabolite levels; BRCA cis rs11098499 0.955 rs1511015 chr4:120170473 A/C cg09307838 chr4:120376055 NA 0.61 12.35 0.44 1.42e-31 Corneal astigmatism; BRCA cis rs61931739 0.500 rs6488218 chr12:34452587 T/C cg06521331 chr12:34319734 NA -0.5 -10.15 -0.37 1.51e-22 Morning vs. evening chronotype; BRCA cis rs7208859 0.623 rs9898084 chr17:29082334 C/G cg13385521 chr17:29058706 SUZ12P 0.77 12.03 0.43 3.31e-30 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs10411936 0.712 rs10414751 chr19:16591695 G/A cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.74 0.36 5.51e-21 White blood cell count;Multiple sclerosis; BRCA cis rs9469890 0.604 rs11756280 chr6:34503439 T/C cg14254433 chr6:34482411 PACSIN1 -0.44 -9.07 -0.34 1.44e-18 Pubertal anthropometrics;Coronary artery disease; BRCA cis rs1198430 1.000 rs946268 chr1:23747766 A/G cg19827787 chr1:23763612 ASAP3 0.37 10.11 0.37 2.16e-22 Total cholesterol levels; BRCA trans rs3780486 0.757 rs10758189 chr9:33125804 A/G cg04842962 chr6:43655489 MRPS18A 1.12 37.64 0.83 2.89e-164 IgG glycosylation; BRCA cis rs4642101 0.765 rs9871991 chr3:12827525 C/A cg24848339 chr3:12840334 CAND2 0.44 11.59 0.42 2.62e-28 QRS complex (12-leadsum); BRCA cis rs4727027 0.704 rs4727031 chr7:148908305 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.41 8.74 0.33 2.07e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs2576037 0.545 rs9948405 chr18:44494527 C/G cg19077165 chr18:44547161 KATNAL2 -0.59 -13.09 -0.46 7.3e-35 Personality dimensions; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg13397359 chr6:42928475 GNMT 0.68 16.45 0.55 5.8e-51 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs1003719 0.667 rs13050226 chr21:38457708 C/T cg10648535 chr21:38446584 PIGP;TTC3 0.51 10.85 0.39 2.78e-25 Eye color traits; BRCA trans rs4332037 0.901 rs7791899 chr7:1935988 T/C cg25206134 chr2:45395956 NA 0.54 8.9 0.33 5.78e-18 Bipolar disorder; BRCA cis rs4689388 0.890 rs6446481 chr4:6295583 C/A cg00701064 chr4:6280414 WFS1 0.68 17.76 0.57 1.17e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7246657 0.943 rs35540940 chr19:38008235 G/A cg23950597 chr19:37808831 NA -0.71 -12.56 -0.44 1.71e-32 Coronary artery calcification; BRCA cis rs17376456 0.935 rs13156002 chr5:93508931 G/A cg09848695 chr5:92956644 FAM172A;MIR2277 0.62 7.98 0.3 6.81e-15 Diabetic retinopathy; BRCA cis rs875971 0.830 rs587360 chr7:65522698 C/A cg18876405 chr7:65276391 NA 0.58 13.86 0.48 2.32e-38 Aortic root size; BRCA cis rs2404602 1.000 rs12443137 chr15:76840832 G/T cg26408565 chr15:76604113 ETFA -0.39 -8.56 -0.32 8.47e-17 Blood metabolite levels; BRCA cis rs35306767 0.807 rs1013505 chr10:953273 C/T cg26597838 chr10:835615 NA 1.02 17.17 0.56 1.33e-54 Eosinophil percentage of granulocytes; BRCA cis rs6032067 0.561 rs2741502 chr20:43936265 C/T cg06407657 chr20:43937138 MATN4;RBPJL 0.28 8.0 0.3 6.07e-15 Blood protein levels; BRCA cis rs780096 0.546 rs1104 chr2:27599875 T/G cg21747090 chr2:27597821 SNX17 -0.44 -9.57 -0.35 2.23e-20 Total body bone mineral density; BRCA cis rs10504229 1.000 rs57624567 chr8:58176995 T/C cg14926445 chr8:58193284 C8orf71 -0.44 -8.4 -0.32 2.81e-16 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.765 rs4374423 chr2:99662348 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs9443645 0.901 rs7767100 chr6:79810533 A/C cg09184832 chr6:79620586 NA -0.52 -11.31 -0.41 3.56e-27 Intelligence (multi-trait analysis); BRCA cis rs6088590 0.648 rs6058105 chr20:33271719 C/T cg08999081 chr20:33150536 PIGU 0.47 12.59 0.45 1.3e-32 Coronary artery disease; BRCA cis rs7666738 0.830 rs34164616 chr4:99015251 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10089 0.953 rs2016015 chr5:127527253 T/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.62 14.24 0.49 3.61e-40 Ileal carcinoids; BRCA trans rs7615952 0.576 rs17523380 chr3:125802874 C/T cg07211511 chr3:129823064 LOC729375 -0.5 -9.3 -0.35 2.17e-19 Blood pressure (smoking interaction); BRCA cis rs6545883 0.931 rs9807965 chr2:61732159 T/C cg15711740 chr2:61764176 XPO1 -0.52 -13.15 -0.46 3.83e-35 Tuberculosis; BRCA cis rs1552244 0.882 rs67631672 chr3:10004768 G/A cg00166722 chr3:10149974 C3orf24 0.59 11.67 0.42 1.22e-28 Alzheimer's disease; BRCA cis rs7666738 0.830 rs1426669 chr4:98945534 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.37e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs11190604 1.000 rs10883504 chr10:102280687 G/A cg07080220 chr10:102295463 HIF1AN 0.61 13.88 0.48 1.76e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6831352 0.918 rs1126672 chr4:100047812 G/A cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg04025307 chr7:1156635 C7orf50 0.58 10.22 0.37 8.3e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2948294 0.588 rs4840913 chr8:8116906 A/C cg15556689 chr8:8085844 FLJ10661 0.48 11.69 0.42 9.95e-29 Red cell distribution width; BRCA cis rs4665809 1.000 rs1550381 chr2:26266946 A/G cg26314531 chr2:26401878 FAM59B -0.66 -11.23 -0.41 7.76e-27 Gut microbiome composition (summer); BRCA cis rs35849525 1.000 rs35849525 chr3:50067350 T/C cg05623727 chr3:50126028 RBM5 0.44 8.33 0.31 5.01e-16 Intelligence (multi-trait analysis); BRCA cis rs835154 0.845 rs835155 chr5:14875868 A/G cg18064842 chr5:14874549 NA 0.46 12.44 0.44 5.84e-32 Blood metabolite levels; BRCA cis rs7267979 0.844 rs2424703 chr20:25270124 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.28 7.86 0.3 1.66e-14 Liver enzyme levels (alkaline phosphatase); BRCA cis rs5167 0.504 rs7248162 chr19:45454686 T/C cg10169327 chr19:45448959 APOC2 0.31 7.81 0.3 2.31e-14 Blood protein levels; BRCA cis rs7312933 0.645 rs12049942 chr12:42587052 G/A cg17420585 chr12:42539391 GXYLT1 -0.38 -8.11 -0.31 2.59e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.46 8.03 0.3 4.58e-15 Mean platelet volume; BRCA cis rs4665809 1.000 rs10048648 chr2:26320315 T/C cg27170947 chr2:26402098 FAM59B -0.64 -11.4 -0.41 1.49e-27 Gut microbiome composition (summer); BRCA cis rs514406 0.858 rs574853 chr1:53310959 A/T cg01802117 chr1:53393560 SCP2 -0.36 -8.39 -0.31 3.15e-16 Monocyte count; BRCA cis rs8114671 0.647 rs6060267 chr20:33734012 A/G cg07148914 chr20:33460835 GGT7 0.35 7.92 0.3 1.08e-14 Height; BRCA cis rs4908768 0.501 rs7518608 chr1:8557320 C/G cg20416874 chr1:8611966 RERE -0.29 -8.21 -0.31 1.22e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs6951245 1.000 rs79422648 chr7:1080241 T/C cg22907277 chr7:1156413 C7orf50 0.59 9.18 0.34 5.82e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.683 rs34804288 chr8:58117570 C/A cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs3008870 0.583 rs3008892 chr1:67373558 A/T cg08660285 chr1:67390436 MIER1;WDR78 0.86 16.25 0.54 5.61e-50 Lymphocyte percentage of white cells; BRCA trans rs2262909 0.962 rs55728714 chr19:22262899 A/G cg17074339 chr11:11642133 GALNTL4 0.42 8.15 0.31 1.93e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs910316 0.663 rs175034 chr14:75463687 T/G cg08847533 chr14:75593920 NEK9 -0.81 -19.85 -0.62 1.08e-68 Height; BRCA cis rs2425143 1.000 rs79035779 chr20:34343004 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.66 -9.16 -0.34 6.69e-19 Blood protein levels; BRCA cis rs10504229 1.000 rs59383954 chr8:58189689 G/A cg14926445 chr8:58193284 C8orf71 -0.46 -8.83 -0.33 1.01e-17 Developmental language disorder (linguistic errors); BRCA cis rs12200560 0.505 rs211166 chr6:97068598 T/C cg06623918 chr6:96969491 KIAA0776 0.53 12.71 0.45 3.61e-33 Coronary heart disease; BRCA cis rs2836974 0.897 rs13052882 chr21:40555351 G/C cg11890956 chr21:40555474 PSMG1 1.09 33.48 0.8 1.04e-142 Cognitive function; BRCA cis rs12824058 0.831 rs12314111 chr12:130813663 G/T cg24229701 chr12:130821962 PIWIL1 0.38 8.59 0.32 6.73e-17 Menopause (age at onset); BRCA cis rs701145 0.585 rs1727957 chr3:153870407 G/A cg17054900 chr3:154042577 DHX36 0.55 9.29 0.35 2.32e-19 Coronary artery disease; BRCA cis rs7927771 0.832 rs896816 chr11:47394338 T/C cg20307385 chr11:47447363 PSMC3 0.39 8.41 0.32 2.75e-16 Subjective well-being; BRCA cis rs6723226 0.593 rs176401 chr2:32636511 A/T cg02381751 chr2:32503542 YIPF4 -0.69 -14.83 -0.51 5.82e-43 Intelligence (multi-trait analysis); BRCA cis rs912057 0.671 rs1024246 chr6:6743505 A/T cg06612196 chr6:6737390 NA 0.46 10.85 0.39 2.86e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs2282802 0.685 rs4913079 chr5:139683029 A/G cg26211634 chr5:139558579 C5orf32 0.34 8.2 0.31 1.35e-15 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs11760844 chr7:65739883 C/G cg11764359 chr7:65958608 NA -0.77 -17.87 -0.58 3.29e-58 Aortic root size; BRCA cis rs769267 0.929 rs2905424 chr19:19473445 T/C cg03709012 chr19:19516395 GATAD2A -0.8 -18.12 -0.58 1.59e-59 Tonsillectomy; BRCA cis rs950776 0.518 rs8025429 chr15:78836362 G/A cg22563815 chr15:78856949 CHRNA5 -0.36 -8.62 -0.32 5.39e-17 Sudden cardiac arrest; BRCA cis rs11098499 0.754 rs2964 chr4:120240131 T/C cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA cis rs4363385 0.747 rs885096 chr1:152971313 T/C cg21543102 chr1:152974771 SPRR3 -0.29 -8.22 -0.31 1.17e-15 Inflammatory skin disease; BRCA cis rs17767294 0.614 rs72854506 chr6:28252497 T/C cg08851530 chr6:28072375 NA 1.14 10.34 0.38 2.73e-23 Parkinson's disease; BRCA cis rs3733585 0.699 rs12498956 chr4:9950705 G/T cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.19e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs12188164 0.561 rs2721010 chr5:456915 A/G cg16584290 chr5:462447 EXOC3 0.53 14.97 0.51 1.18e-43 Cystic fibrosis severity; BRCA cis rs72634258 0.554 rs4908704 chr1:7918904 A/G cg26816564 chr1:7831052 VAMP3 0.54 10.71 0.39 9.93e-25 Inflammatory bowel disease; BRCA cis rs10129255 0.500 rs6576230 chr14:107186778 C/A cg07958169 chr14:107095056 NA -0.4 -8.67 -0.32 3.43e-17 Kawasaki disease; BRCA cis rs9814567 0.806 rs9839705 chr3:134323819 T/C cg06541857 chr3:134203789 ANAPC13;CEP63 -0.37 -8.52 -0.32 1.18e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7811142 0.830 rs61735533 chr7:99955866 G/A cg11814155 chr7:99998594 ZCWPW1 0.45 8.1 0.31 2.86e-15 Platelet count; BRCA cis rs10504229 1.000 rs67039591 chr8:58174553 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs17253792 0.915 rs79894275 chr14:56180285 C/T cg01858014 chr14:56050164 KTN1 -0.67 -8.24 -0.31 9.82e-16 Putamen volume; BRCA cis rs61990749 0.597 rs10136053 chr14:78155205 G/A cg02301378 chr14:78227641 SNW1;C14orf178 -0.64 -10.16 -0.37 1.4e-22 Fibroblast growth factor basic levels; BRCA cis rs1994135 0.692 rs7297538 chr12:33693438 T/C cg06521331 chr12:34319734 NA -0.52 -8.98 -0.33 3.03e-18 Resting heart rate; BRCA cis rs78456975 0.943 rs13391932 chr2:1577679 T/C cg01028140 chr2:1542097 TPO -0.62 -11.77 -0.42 4.54e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4478858 0.709 rs7514640 chr1:31752316 G/A cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs17253792 0.822 rs28478195 chr14:56047851 G/A cg01858014 chr14:56050164 KTN1 -0.77 -11.27 -0.41 5.52e-27 Putamen volume; BRCA cis rs7666738 0.830 rs28416660 chr4:98899525 C/G cg17366294 chr4:99064904 C4orf37 0.42 9.76 0.36 4.44e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs3008870 0.920 rs12132532 chr1:67457015 G/T cg08660285 chr1:67390436 MIER1;WDR78 -0.98 -21.61 -0.65 3.57e-78 Lymphocyte percentage of white cells; BRCA cis rs9399137 0.507 rs11754021 chr6:135308375 A/G cg24558204 chr6:135376177 HBS1L 0.59 15.94 0.53 2.02e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.94 -19.93 -0.62 4.02e-69 Gut microbiome composition (summer); BRCA cis rs9443645 0.527 rs12194642 chr6:79538791 G/A cg09184832 chr6:79620586 NA -0.41 -8.04 -0.3 4.5e-15 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.733 rs12254018 chr10:35550641 T/A cg03585969 chr10:35415529 CREM 0.43 8.64 0.32 4.64e-17 Inflammatory bowel disease;Crohn's disease; BRCA cis rs514406 0.929 rs11206035 chr1:53323571 T/C cg01802117 chr1:53393560 SCP2 -0.36 -8.38 -0.31 3.43e-16 Monocyte count; BRCA cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.79 0.6 4.9e-63 Cognitive function; BRCA cis rs7248779 0.512 rs12610522 chr19:2413228 C/T cg22729335 chr19:2427816 TIMM13 1.0 25.41 0.71 5.84e-99 Cortisol levels (saliva); BRCA trans rs9325144 0.647 rs12229104 chr12:39110811 T/A cg23762105 chr12:34175262 ALG10 0.34 7.81 0.3 2.34e-14 Morning vs. evening chronotype; BRCA cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg01028140 chr2:1542097 TPO -0.57 -11.83 -0.42 2.35e-29 IgG glycosylation; BRCA cis rs7914558 0.966 rs1971589 chr10:104744406 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.77 0.39 5.57e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs3733585 0.699 rs6844316 chr4:9958977 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -10.55 -0.39 4.09e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs877282 0.945 rs11253398 chr10:790012 T/C cg17470449 chr10:769945 NA 0.51 8.62 0.32 5.29e-17 Uric acid levels; BRCA cis rs7811142 0.779 rs111312383 chr7:99905325 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.99 16.31 0.54 3.05e-50 Platelet count; BRCA cis rs10911232 0.560 rs6697320 chr1:183037377 T/G ch.1.3577855R chr1:183094577 LAMC1 0.6 14.96 0.51 1.38e-43 Hypertriglyceridemia; BRCA cis rs4363385 0.510 rs6661063 chr1:153036048 C/A cg25856811 chr1:152973957 SPRR3 -0.31 -7.93 -0.3 1e-14 Inflammatory skin disease; BRCA cis rs1577917 1.000 rs16876529 chr6:86591202 T/C cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -11.92 -0.43 9.73e-30 Response to antipsychotic treatment; BRCA trans rs7819412 0.806 rs6980856 chr8:10938260 A/G cg06636001 chr8:8085503 FLJ10661 0.52 10.46 0.38 9.47e-24 Triglycerides; BRCA cis rs7309 0.935 rs6432674 chr2:162025322 G/T cg00599163 chr2:162100495 NA 0.27 8.93 0.33 4.59e-18 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs2120243 0.782 rs7609926 chr3:157149160 T/C cg01018701 chr3:157155998 VEPH1;PTX3 0.43 9.49 0.35 4.61e-20 Hepatocellular carcinoma in hepatitis B infection; BRCA cis rs4665809 0.590 rs1056389 chr2:26502875 T/C cg26314531 chr2:26401878 FAM59B 0.96 16.36 0.54 1.59e-50 Gut microbiome composition (summer); BRCA cis rs11893307 0.566 rs13412750 chr2:191634958 C/T cg05765582 chr2:191677683 NA 0.45 8.08 0.3 3.16e-15 Mean platelet volume; BRCA cis rs6570726 0.935 rs376991 chr6:145828073 G/C cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 0.682 rs3014241 chr1:46087879 A/G cg06784218 chr1:46089804 CCDC17 -0.53 -12.64 -0.45 7.87e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs853679 0.517 rs17774663 chr6:28120898 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.28 7.96 0.3 7.77e-15 Depression; BRCA trans rs6582630 0.502 rs1115515 chr12:38279830 C/T cg06521331 chr12:34319734 NA -0.5 -9.25 -0.34 3.41e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs2019137 0.589 rs7560701 chr2:114026882 C/G cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.43 8.43 0.32 2.38e-16 Lymphocyte counts; BRCA cis rs11676348 0.791 rs6726126 chr2:218952233 G/A cg20019365 chr2:219134978 PNKD;AAMP -0.4 -8.36 -0.31 3.84e-16 Ulcerative colitis; BRCA cis rs3806843 0.900 rs2531341 chr5:140130894 C/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.16 0.34 7.11e-19 Depressive symptoms (multi-trait analysis); BRCA trans rs2204008 0.775 rs11514369 chr12:38305411 C/T cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Bladder cancer; BRCA cis rs7552404 0.924 rs1611823 chr1:76221706 T/G cg03433033 chr1:76189801 ACADM 0.73 18.53 0.59 1.12e-61 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9457247 0.534 rs4710149 chr6:167386346 T/C cg23791538 chr6:167370224 RNASET2 0.51 13.03 0.46 1.33e-34 Crohn's disease; BRCA cis rs11920090 0.932 rs12495622 chr3:170684878 A/G cg09710316 chr3:170744871 SLC2A2 0.41 7.93 0.3 9.56e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs4363385 0.693 rs608509 chr1:153034650 G/C cg24667326 chr1:152973720 SPRR3 -0.31 -8.24 -0.31 9.68e-16 Inflammatory skin disease; BRCA cis rs6840360 0.615 rs4696097 chr4:152479765 C/T cg22705602 chr4:152727874 NA 0.33 8.46 0.32 1.86e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs4665840 chr2:26444962 C/T cg26314531 chr2:26401878 FAM59B -0.88 -15.31 -0.52 2.56e-45 Gut microbiome composition (summer); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg07092213 chr7:1199455 ZFAND2A -0.51 -11.62 -0.42 1.85e-28 Longevity;Endometriosis; BRCA cis rs4566357 0.615 rs2272204 chr2:227915601 G/T cg11843606 chr2:227700838 RHBDD1 -0.43 -9.58 -0.35 2.16e-20 Coronary artery disease; BRCA cis rs2464469 0.526 rs11071363 chr15:58333961 A/G cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.67 -0.36 9.65e-21 Barrett's esophagus or Esophageal adenocarcinoma; BRCA cis rs9311474 0.629 rs13081028 chr3:52555316 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.36 7.95 0.3 8.38e-15 Electroencephalogram traits; BRCA cis rs3617 0.625 rs2535633 chr3:52859630 C/G cg11645453 chr3:52864694 ITIH4 -0.37 -9.73 -0.36 5.9e-21 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs4727027 0.933 rs12540094 chr7:148847178 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 -0.39 -9.3 -0.35 2.26e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs10256972 0.567 rs7782651 chr7:1159895 T/G cg26608667 chr7:1196370 ZFAND2A 0.45 10.01 0.37 5.21e-22 Longevity;Endometriosis; BRCA cis rs7246967 0.673 rs2194112 chr19:22926189 A/C cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA cis rs829883 0.872 rs1641641 chr12:98896018 A/C cg25150519 chr12:98850993 NA 0.59 11.9 0.43 1.19e-29 Colorectal adenoma (advanced); BRCA cis rs6964587 0.967 rs6465341 chr7:91596121 G/C cg17063962 chr7:91808500 NA 0.52 12.28 0.44 2.75e-31 Breast cancer; BRCA cis rs595982 0.559 rs17272680 chr19:49364511 A/G cg15549821 chr19:49342101 PLEKHA4 0.62 10.33 0.38 3.07e-23 Red cell distribution width; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg08888203 chr3:10149979 C3orf24 0.68 14.44 0.5 4.29e-41 Alzheimer's disease; BRCA cis rs4800452 0.956 rs7235010 chr18:20724810 G/A cg26136497 chr18:20735537 CABLES1 -0.38 -9.4 -0.35 9.77e-20 Height;Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction); BRCA cis rs17685 0.672 rs1639618 chr7:75701987 T/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.39 -8.85 -0.33 8.3e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6598955 1.000 rs10902728 chr1:26598281 T/C cg00852783 chr1:26633632 UBXN11 -0.48 -10.09 -0.37 2.56e-22 Obesity-related traits; BRCA cis rs11031096 0.711 rs4910891 chr11:4153408 A/G cg18678763 chr11:4115507 RRM1 -0.38 -8.58 -0.32 7.01e-17 Mean corpuscular volume;Mean corpuscular hemoglobin; BRCA cis rs2153535 0.580 rs9378556 chr6:8514695 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.65 0.39 1.73e-24 Motion sickness; BRCA cis rs7762018 0.655 rs11966349 chr6:170162537 A/G cg19338460 chr6:170058176 WDR27 0.47 8.25 0.31 9.14e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs6844506 0.565 rs10008153 chr4:185227184 C/T cg12654155 chr4:185238627 NA -0.42 -8.75 -0.33 1.88e-17 Gestational age at birth in premature rupture of membrane-initiated deliveries (child effect); BRCA cis rs6570726 0.846 rs397311 chr6:145806701 C/T cg13319975 chr6:146136371 FBXO30 0.34 8.02 0.3 5.07e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7829975 0.623 rs10092965 chr8:8373485 A/G cg14343924 chr8:8086146 FLJ10661 0.43 9.14 0.34 8.44e-19 Mood instability; BRCA cis rs6547741 1.000 rs6750943 chr2:27777904 T/G cg27432699 chr2:27873401 GPN1 0.47 9.88 0.36 1.66e-21 Oral cavity cancer; BRCA cis rs7520050 0.966 rs2486447 chr1:46545724 G/A cg24296786 chr1:45957014 TESK2 0.43 9.77 0.36 4.17e-21 Red blood cell count;Reticulocyte count; BRCA cis rs6840360 0.615 rs12641433 chr4:152607548 A/C cg22705602 chr4:152727874 NA -0.38 -10.38 -0.38 2.01e-23 Intelligence (multi-trait analysis); BRCA trans rs11098499 0.874 rs9995277 chr4:120108603 G/A cg25214090 chr10:38739885 LOC399744 0.51 10.47 0.38 8.45e-24 Corneal astigmatism; BRCA cis rs796364 0.901 rs4673762 chr2:201065171 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.48 8.52 0.32 1.11e-16 Schizophrenia; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg23708337 chr7:1209742 NA 0.68 10.25 0.38 6.32e-23 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4819052 0.851 rs1999335 chr21:46670613 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.57 0.35 2.35e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8180040 0.966 rs12636851 chr3:47463567 C/T cg27129171 chr3:47204927 SETD2 0.66 15.67 0.53 4.58e-47 Colorectal cancer; BRCA cis rs4689388 0.926 rs3889821 chr4:6282596 C/T cg00701064 chr4:6280414 WFS1 0.69 18.98 0.6 4.71e-64 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7799006 0.606 rs7792045 chr7:2316852 C/T cg08027265 chr7:2291960 NA -0.45 -11.74 -0.42 6.08e-29 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7811142 1.000 rs11761784 chr7:100039970 C/T cg11814155 chr7:99998594 ZCWPW1 0.43 8.07 0.3 3.38e-15 Platelet count; BRCA trans rs7618501 0.966 rs2352974 chr3:49890613 C/T cg21582582 chr3:182698605 DCUN1D1 0.38 10.03 0.37 4.41e-22 Intelligence (multi-trait analysis); BRCA cis rs1577917 1.000 rs11758849 chr6:86708262 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.44 -10.63 -0.39 2.03e-24 Response to antipsychotic treatment; BRCA cis rs1059312 0.808 rs12816551 chr12:129295616 T/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.79 -19.86 -0.62 1e-68 Systemic lupus erythematosus; BRCA cis rs7267979 1.000 rs6107033 chr20:25363591 A/G cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.17 -0.34 6.46e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1707322 0.721 rs28641748 chr1:46212836 A/G cg06784218 chr1:46089804 CCDC17 0.51 12.17 0.43 8.34e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1707322 0.721 rs6665808 chr1:46162283 C/T cg06784218 chr1:46089804 CCDC17 0.49 11.62 0.42 1.96e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7493 0.853 rs17166879 chr7:95053415 A/G cg19678392 chr7:94953810 PON1 -0.42 -8.54 -0.32 1e-16 Yu-Zhi constitution type in type 2 diabetes; BRCA trans rs2727020 0.619 rs1164665 chr11:49295630 T/C cg15704280 chr7:45808275 SEPT13 0.69 14.09 0.49 1.88e-39 Coronary artery disease; BRCA cis rs17685 0.753 rs869804 chr7:75688954 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.95 -0.33 3.76e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs11718455 0.767 rs6785433 chr3:43964265 A/G cg08738300 chr3:44038990 NA 0.48 8.85 0.33 8.61e-18 Coronary artery disease; BRCA cis rs9311474 0.508 rs2878628 chr3:52584715 C/T cg11041457 chr3:52719354 GNL3;PBRM1 -0.37 -12.76 -0.45 2.2e-33 Electroencephalogram traits; BRCA cis rs36051895 0.626 rs10283563 chr9:5075603 C/T cg02405213 chr9:5042618 JAK2 -0.5 -9.64 -0.36 1.22e-20 Pediatric autoimmune diseases; BRCA cis rs13108904 0.901 rs12641735 chr4:1304434 G/C cg01939980 chr4:1354348 KIAA1530 0.3 7.81 0.3 2.29e-14 Obesity-related traits; BRCA trans rs11098499 0.954 rs7681544 chr4:120411255 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.96 0.43 7.08e-30 Corneal astigmatism; BRCA cis rs12142240 0.698 rs7515598 chr1:46818479 C/T cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs7312933 0.702 rs10785333 chr12:42586470 A/G cg01256987 chr12:42539512 GXYLT1 0.46 9.11 0.34 1.04e-18 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6545883 0.965 rs6734830 chr2:61731112 G/A cg15711740 chr2:61764176 XPO1 -0.52 -13.14 -0.46 4.2e-35 Tuberculosis; BRCA cis rs7267979 1.000 rs11087520 chr20:25436827 C/T cg08601574 chr20:25228251 PYGB 0.33 8.03 0.3 4.73e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9381040 0.610 rs4140579 chr6:41041752 G/A cg25110423 chr6:41068646 NFYA;LOC221442 -0.37 -8.8 -0.33 1.26e-17 Alzheimer's disease (late onset); BRCA cis rs7833790 0.660 rs7839178 chr8:82763479 A/G cg02079420 chr8:82753780 SNX16 -0.31 -8.32 -0.31 5.45e-16 Diastolic blood pressure; BRCA cis rs9796 0.621 rs557864 chr15:41471358 T/C cg18705301 chr15:41695430 NDUFAF1 0.37 7.92 0.3 1.03e-14 Menopause (age at onset); BRCA cis rs11997175 0.583 rs7829680 chr8:33794207 C/T ch.8.33884649F chr8:33765107 NA -0.36 -8.36 -0.31 4.05e-16 Body mass index; BRCA cis rs13040088 1.000 rs13040088 chr20:61549202 A/G cg23096297 chr20:61557774 DIDO1 0.91 18.93 0.6 8.83e-64 Menopause (age at onset); BRCA cis rs6032067 0.673 rs991048 chr20:43898227 C/T cg20256260 chr20:43936981 MATN4;RBPJL -0.34 -8.31 -0.31 5.95e-16 Blood protein levels; BRCA cis rs4074536 0.614 rs4075008 chr1:116298064 C/A cg21648376 chr1:116311395 CASQ2 -0.45 -7.99 -0.3 6.11e-15 QRS duration; BRCA cis rs10206020 0.842 rs7609325 chr2:1574718 G/A cg12573674 chr2:1569213 NA -0.58 -12.86 -0.45 8.4e-34 IgG glycosylation; BRCA cis rs7254827 0.737 rs62126021 chr19:17159723 C/G cg19418318 chr19:17219073 MYO9B -0.48 -10.08 -0.37 2.82e-22 Mean platelet volume; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg00149659 chr3:10157352 C3orf10 1.07 18.1 0.58 2.08e-59 Alzheimer's disease; BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.03 0.3 4.62e-15 Tonsillectomy; BRCA cis rs10751667 0.643 rs11246362 chr11:969818 C/T cg10932868 chr11:921992 NA 0.49 12.38 0.44 1.09e-31 Alzheimer's disease (late onset); BRCA cis rs2204008 0.748 rs11514352 chr12:38246954 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.0 0.56 9.05e-54 Bladder cancer; BRCA cis rs614226 0.938 rs7963543 chr12:120923948 C/A cg01236616 chr12:121019343 POP5 1.21 27.84 0.74 2.68e-112 Type 1 diabetes nephropathy; BRCA cis rs2243480 1.000 rs316318 chr7:65612904 A/G cg18252515 chr7:66147081 NA -1.04 -15.49 -0.52 3.67e-46 Diabetic kidney disease; BRCA cis rs9649465 0.542 rs616297 chr7:123426949 A/G cg03229431 chr7:123269106 ASB15 0.43 9.73 0.36 6.01e-21 Migraine; BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg18230493 chr5:56204884 C5orf35 -0.72 -14.34 -0.49 1.2e-40 Initial pursuit acceleration; BRCA cis rs7927771 0.524 rs11039392 chr11:47798753 A/G cg20307385 chr11:47447363 PSMC3 0.42 9.54 0.35 2.88e-20 Subjective well-being; BRCA cis rs12973672 1.000 rs2280747 chr19:35770064 C/T cg12095397 chr19:35769544 USF2 0.38 8.41 0.32 2.58e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs35110281 0.782 rs2329442 chr21:45041790 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.48 10.37 0.38 2.16e-23 Mean corpuscular volume; BRCA cis rs3771570 0.901 rs62190415 chr2:242426692 A/G cg21155796 chr2:242212141 HDLBP 0.56 9.4 0.35 9.57e-20 Prostate cancer; BRCA cis rs10752881 0.935 rs12082051 chr1:183051614 C/T ch.1.3577855R chr1:183094577 LAMC1 0.65 17.01 0.56 8.71e-54 Colorectal cancer; BRCA cis rs8031584 0.958 rs11293 chr15:31234981 G/A cg08109568 chr15:31115862 NA -0.45 -10.4 -0.38 1.58e-23 Huntington's disease progression; BRCA cis rs9393777 0.623 rs9348719 chr6:26470032 T/C cg12826209 chr6:26865740 GUSBL1 0.56 9.25 0.34 3.41e-19 Intelligence (multi-trait analysis); BRCA cis rs1568889 1.000 rs7931847 chr11:28175245 G/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.63 13.35 0.47 4.92e-36 Bipolar disorder; BRCA cis rs12477438 0.765 rs1115757 chr2:99660146 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs2842992 0.747 rs733319 chr6:160221475 A/G cg11366901 chr6:160182831 ACAT2 0.85 16.31 0.54 3.02e-50 Age-related macular degeneration (geographic atrophy); BRCA cis rs2075371 0.579 rs11766422 chr7:134018160 T/C cg11752832 chr7:134001865 SLC35B4 0.44 9.61 0.36 1.6e-20 Mean platelet volume; BRCA cis rs7927771 0.542 rs11039336 chr11:47706141 A/G cg20307385 chr11:47447363 PSMC3 -0.39 -9.06 -0.34 1.57e-18 Subjective well-being; BRCA cis rs7809615 0.901 rs13243267 chr7:99053314 C/G cg12290671 chr7:99195819 NA 0.5 8.81 0.33 1.18e-17 Blood metabolite ratios; BRCA cis rs13053817 1.000 rs71329486 chr22:29831208 G/A cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.47 -8.95 -0.33 3.85e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg02546618 chr19:19431379 KIAA0892;SF4 0.39 9.39 0.35 1e-19 Tonsillectomy; BRCA cis rs8072100 0.748 rs9912592 chr17:45556945 G/A cg25173405 chr17:45401733 C17orf57 -0.53 -11.22 -0.41 8.92e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10752881 1.000 rs4420053 chr1:182976133 A/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs7520050 0.933 rs9787208 chr1:46314616 C/A cg24296786 chr1:45957014 TESK2 0.41 9.35 0.35 1.5e-19 Red blood cell count;Reticulocyte count; BRCA cis rs1538970 0.924 rs4660851 chr1:45843810 A/T cg05343316 chr1:45956843 TESK2 0.53 11.04 0.4 4.84e-26 Platelet count; BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.69 -12.82 -0.45 1.21e-33 Gut microbiome composition (summer); BRCA cis rs36051895 0.632 rs7036536 chr9:5181610 T/C cg02405213 chr9:5042618 JAK2 -0.48 -9.37 -0.35 1.22e-19 Pediatric autoimmune diseases; BRCA cis rs8170 0.603 rs7249329 chr19:17423373 G/T cg04749549 chr19:17459798 NA -0.36 -9.67 -0.36 9.58e-21 Breast cancer (estrogen-receptor negative);Breast Cancer in BRCA1 mutation carriers;Ovarian cancer;Breast cancer;Epithelial ovarian cancer; BRCA cis rs7766436 0.848 rs6931450 chr6:22582076 T/C cg13666174 chr6:22585274 NA -0.49 -11.6 -0.42 2.25e-28 Coronary artery disease; BRCA cis rs763121 0.819 rs4560233 chr22:38982442 A/T cg14440974 chr22:39074834 NA -0.39 -8.75 -0.33 1.87e-17 Menopause (age at onset); BRCA cis rs2839186 0.500 rs13049893 chr21:47707054 C/T cg12379764 chr21:47803548 PCNT -0.6 -12.01 -0.43 4.12e-30 Testicular germ cell tumor; BRCA cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg11644478 chr21:40555479 PSMG1 0.84 19.24 0.61 2.1e-65 Cognitive function; BRCA cis rs17401966 1.000 rs11576866 chr1:10414432 A/G cg03954927 chr1:10346856 KIF1B 0.45 12.58 0.45 1.33e-32 Hepatocellular carcinoma; BRCA trans rs3749237 1.000 rs6804655 chr3:49738945 C/T cg21659725 chr3:3221576 CRBN 0.51 12.07 0.43 2.37e-30 Resting heart rate; BRCA cis rs651907 0.514 rs12636047 chr3:101434449 T/C cg12386194 chr3:101231763 SENP7 0.46 9.92 0.37 1.18e-21 Colorectal cancer; BRCA cis rs877282 0.853 rs12763400 chr10:763617 C/T cg17470449 chr10:769945 NA 0.47 7.92 0.3 1.08e-14 Uric acid levels; BRCA cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg11833968 chr6:79620685 NA -0.38 -8.54 -0.32 1.01e-16 Intelligence (multi-trait analysis); BRCA cis rs9733 0.596 rs11803569 chr1:150664077 C/T cg17724175 chr1:150552817 MCL1 0.25 8.22 0.31 1.17e-15 Tonsillectomy; BRCA cis rs4727027 0.933 rs4725800 chr7:148862516 C/G cg23583168 chr7:148888333 NA -0.79 -18.85 -0.6 2.3e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7615952 0.599 rs1044215 chr3:125725559 C/G cg06494592 chr3:125709126 NA -0.5 -8.53 -0.32 1.06e-16 Blood pressure (smoking interaction); BRCA cis rs832540 0.931 rs832399 chr5:56222358 A/T cg24531977 chr5:56204891 C5orf35 -0.41 -8.41 -0.32 2.64e-16 Coronary artery disease; BRCA cis rs6860806 0.661 rs2136188 chr5:131577514 A/G cg18758796 chr5:131593413 PDLIM4 -0.34 -8.72 -0.33 2.37e-17 Breast cancer; BRCA cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg19318889 chr4:1322082 MAEA 0.35 8.04 0.3 4.48e-15 Longevity; BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg08888203 chr3:10149979 C3orf24 0.67 14.07 0.49 2.42e-39 Alzheimer's disease; BRCA cis rs7116495 0.609 rs2503 chr11:71719403 C/T cg26138937 chr11:71823887 C11orf51 1.05 10.16 0.37 1.39e-22 Severe influenza A (H1N1) infection; BRCA cis rs1707322 0.721 rs9793568 chr1:46130373 G/A cg06784218 chr1:46089804 CCDC17 0.51 12.36 0.44 1.28e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs6964587 0.935 rs28412174 chr7:91577245 T/G cg17063962 chr7:91808500 NA -0.54 -12.61 -0.45 1.01e-32 Breast cancer; BRCA trans rs61931739 0.500 rs56056630 chr12:34543465 T/C cg26384229 chr12:38710491 ALG10B 0.59 13.61 0.47 3.04e-37 Morning vs. evening chronotype; BRCA trans rs1994135 0.617 rs2200155 chr12:33734935 G/A cg26384229 chr12:38710491 ALG10B 0.49 10.53 0.38 5.18e-24 Resting heart rate; BRCA cis rs8028182 0.577 rs8023268 chr15:75814672 A/T cg20655648 chr15:75932815 IMP3 0.42 8.06 0.3 3.87e-15 Sudden cardiac arrest; BRCA cis rs6815814 0.851 rs17582921 chr4:38892649 T/C cg02016764 chr4:38805732 TLR1 -0.54 -8.69 -0.33 3.02e-17 Breast cancer; BRCA cis rs7246657 0.882 rs28623164 chr19:37913453 G/A cg23950597 chr19:37808831 NA -0.62 -11.45 -0.41 9.99e-28 Coronary artery calcification; BRCA cis rs7523273 0.548 rs2724381 chr1:207949017 T/C cg22525895 chr1:207977042 MIR29B2 0.47 11.98 0.43 5.36e-30 Schizophrenia; BRCA cis rs7615952 0.599 rs6438953 chr3:125724951 T/C cg15145296 chr3:125709740 NA -0.53 -9.12 -0.34 9.63e-19 Blood pressure (smoking interaction); BRCA cis rs4727027 0.933 rs1044358 chr7:148879951 C/A cg12479418 chr7:148823350 ZNF425;ZNF398 0.53 11.15 0.4 1.68e-26 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7249142 0.549 rs741706 chr19:19281672 C/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B -0.39 -8.46 -0.32 1.82e-16 IgG glycosylation; BRCA cis rs2019137 1.000 rs2019137 chr2:113973632 G/A cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.58 -11.53 -0.42 4.45e-28 Lymphocyte counts; BRCA cis rs11080107 0.542 rs894606 chr17:27909352 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.39 9.06 0.34 1.63e-18 Coronary artery disease; BRCA cis rs586533 0.846 rs1690816 chr11:99496849 C/T cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs1506403 0.685 rs1994497 chr7:142816927 A/G cg15652212 chr7:142981776 TMEM139 0.44 8.48 0.32 1.53e-16 Cancer; BRCA cis rs6545883 1.000 rs778762 chr2:61782921 G/T cg15711740 chr2:61764176 XPO1 -0.55 -14.06 -0.49 2.58e-39 Tuberculosis; BRCA trans rs1005277 0.579 rs2474608 chr10:38457109 C/T cg23533926 chr12:111358616 MYL2 -0.42 -8.75 -0.33 1.93e-17 Extrinsic epigenetic age acceleration; BRCA cis rs2251381 0.722 rs2776252 chr21:30531705 G/A cg24692254 chr21:30365293 RNF160 0.65 14.49 0.5 2.46e-41 Selective IgA deficiency; BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg26119090 chr2:26468346 HADHA;HADHB -0.66 -12.02 -0.43 3.84e-30 Gut microbiome composition (summer); BRCA cis rs56104184 0.775 rs117016425 chr19:49400216 C/T cg21252483 chr19:49399788 TULP2 -0.51 -10.86 -0.39 2.46e-25 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs76419734 0.510 rs17036102 chr4:106603098 C/T cg24545054 chr4:106630052 GSTCD;INTS12 -0.54 -12.16 -0.43 9.21e-31 Post bronchodilator FEV1; BRCA cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg23521905 chr12:129298690 SLC15A4;MGC16384 0.34 11.35 0.41 2.54e-27 Systemic lupus erythematosus; BRCA cis rs9287719 0.601 rs12692412 chr2:10720054 A/G cg00105475 chr2:10696890 NA -0.47 -10.42 -0.38 1.41e-23 Prostate cancer; BRCA cis rs798554 0.757 rs2533882 chr7:2846894 G/T cg23285459 chr7:2802560 GNA12 -0.38 -9.63 -0.36 1.42e-20 Height; BRCA trans rs11098499 0.866 rs12374352 chr4:120281977 C/T cg25214090 chr10:38739885 LOC399744 0.49 11.45 0.41 1e-27 Corneal astigmatism; BRCA cis rs2415984 0.622 rs12437018 chr14:46937149 A/G cg14871534 chr14:47121158 RPL10L -0.33 -8.03 -0.3 4.67e-15 Number of children ever born; BRCA cis rs1008375 1.000 rs10009541 chr4:17682218 C/T cg16339924 chr4:17578868 LAP3 -0.55 -13.23 -0.46 1.78e-35 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7615952 0.599 rs16834938 chr3:125706046 C/T cg18479299 chr3:125709523 NA -0.56 -9.14 -0.34 8.19e-19 Blood pressure (smoking interaction); BRCA cis rs36051895 0.622 rs12335546 chr9:5072182 C/T cg02405213 chr9:5042618 JAK2 -0.51 -9.9 -0.36 1.35e-21 Pediatric autoimmune diseases; BRCA cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg06115741 chr20:33292138 TP53INP2 -0.39 -8.48 -0.32 1.54e-16 Glomerular filtration rate (creatinine); BRCA cis rs6701037 0.748 rs10912901 chr1:175138602 G/A cg17845761 chr1:175162550 KIAA0040 -0.25 -9.57 -0.35 2.36e-20 Alcohol dependence; BRCA cis rs911119 1.000 rs6036478 chr20:23611359 C/A cg16589663 chr20:23618590 CST3 0.45 8.47 0.32 1.72e-16 Chronic kidney disease; BRCA cis rs9811920 0.809 rs4928150 chr3:99685991 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.57 13.86 0.48 2.15e-38 Axial length; BRCA cis rs9807989 0.507 rs11465721 chr2:103063240 T/G cg03938978 chr2:103052716 IL18RAP 0.29 8.33 0.31 4.8e-16 Asthma; BRCA cis rs12142240 0.698 rs67276232 chr1:46825484 T/G cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs9815354 0.812 rs73069213 chr3:41940590 G/A cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.82e-20 Pulse pressure;Diastolic blood pressure; BRCA trans rs61931739 0.500 rs7977186 chr12:34431486 C/G cg13010199 chr12:38710504 ALG10B 0.49 9.55 0.35 2.82e-20 Morning vs. evening chronotype; BRCA cis rs897984 0.609 rs12445650 chr16:31044897 G/A cg02466173 chr16:30829666 NA -0.42 -9.39 -0.35 1.04e-19 Dementia with Lewy bodies; BRCA cis rs4561483 0.771 rs7202234 chr16:11942322 A/G cg08843971 chr16:11963173 GSPT1 0.42 9.04 0.34 1.8e-18 Testicular germ cell tumor; BRCA trans rs11098499 0.754 rs1980027 chr4:120251577 C/T cg25214090 chr10:38739885 LOC399744 0.46 10.55 0.39 4.16e-24 Corneal astigmatism; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.55 8.42 0.32 2.56e-16 Gut microbiome composition (summer); BRCA cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg05707623 chr12:122985044 ZCCHC8 -0.51 -10.21 -0.37 8.76e-23 Body mass index; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.84 14.09 0.49 1.82e-39 Alzheimer's disease; BRCA cis rs2882667 0.654 rs2940595 chr5:138101037 A/G cg04439458 chr5:138467593 SIL1 0.31 7.87 0.3 1.47e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs17253792 0.822 rs13379343 chr14:56050205 G/A cg01858014 chr14:56050164 KTN1 -0.77 -11.27 -0.41 5.52e-27 Putamen volume; BRCA cis rs9811920 0.638 rs793474 chr3:99544380 C/T cg07805332 chr3:99536008 MIR548G;C3orf26 -0.37 -8.28 -0.31 7.14e-16 Axial length; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg23131131 chr22:24373011 LOC391322 0.46 10.64 0.39 1.91e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6446731 0.593 rs6446726 chr4:3274214 T/C cg08886695 chr4:3369023 RGS12 -0.38 -9.92 -0.37 1.1e-21 Mean platelet volume; BRCA cis rs1403694 0.695 rs5029969 chr3:186434405 G/T cg12454167 chr3:186435060 KNG1 0.29 7.92 0.3 1.05e-14 Blood protein levels; BRCA cis rs1008375 0.897 rs6820164 chr4:17630115 G/A cg16339924 chr4:17578868 LAP3 0.68 16.58 0.55 1.32e-51 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7092929 0.723 rs7082020 chr10:3535672 T/C cg14308648 chr10:3568949 NA 0.4 8.74 0.33 2.04e-17 Coronary artery calcification; BRCA cis rs801193 0.569 rs13226966 chr7:66233623 A/G cg11764359 chr7:65958608 NA 0.73 16.44 0.55 6.54e-51 Aortic root size; BRCA cis rs7760949 0.852 rs9464423 chr6:13931851 A/G cg27413430 chr6:13925136 RNF182 0.47 9.3 0.35 2.2e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs6840360 0.615 rs4696095 chr4:152467243 A/G cg25486957 chr4:152246857 NA -0.36 -7.9 -0.3 1.26e-14 Intelligence (multi-trait analysis); BRCA cis rs4722404 0.560 rs6975818 chr7:3115520 C/G cg19214707 chr7:3157722 NA -0.36 -7.94 -0.3 9e-15 Atopic dermatitis; BRCA cis rs2882667 1.000 rs10515505 chr5:138313146 A/G cg04439458 chr5:138467593 SIL1 -0.34 -9.23 -0.34 4.07e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs13118159 0.872 rs3903127 chr4:1348806 A/C cg16405210 chr4:1374714 KIAA1530 -0.52 -11.85 -0.42 1.95e-29 Longevity; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.16e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7072216 0.691 rs3829853 chr10:100171174 A/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.71 -0.36 7.24e-21 Metabolite levels; BRCA cis rs7766436 0.767 rs13200993 chr6:22612912 C/T cg13666174 chr6:22585274 NA -0.36 -9.15 -0.34 7.28e-19 Coronary artery disease; BRCA cis rs3820928 0.874 rs2272198 chr2:227893017 A/G cg11843606 chr2:227700838 RHBDD1 0.38 8.47 0.32 1.66e-16 Pulmonary function; BRCA cis rs7772486 0.782 rs7747576 chr6:146277827 C/T cg13319975 chr6:146136371 FBXO30 0.41 9.25 0.34 3.19e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs11249608 0.548 rs11958355 chr5:178451640 T/C cg21905437 chr5:178450457 ZNF879 0.54 11.31 0.41 3.58e-27 Pubertal anthropometrics; BRCA cis rs6860806 0.507 rs2631372 chr5:131703578 C/G cg24060327 chr5:131705240 SLC22A5 -0.54 -9.65 -0.36 1.14e-20 Breast cancer; BRCA trans rs11098499 0.754 rs4107728 chr4:120253910 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.4 0.38 1.71e-23 Corneal astigmatism; BRCA cis rs12893668 0.572 rs11846404 chr14:104156108 C/G cg26031613 chr14:104095156 KLC1 -0.53 -9.5 -0.35 3.97e-20 Reticulocyte count; BRCA trans rs3780486 0.757 rs10813949 chr9:33123464 G/A cg04842962 chr6:43655489 MRPS18A 1.12 38.92 0.84 9.43e-171 IgG glycosylation; BRCA cis rs478304 0.651 rs11227281 chr11:65496558 T/C cg10518572 chr11:65560635 OVOL1 -0.28 -8.11 -0.31 2.52e-15 Acne (severe); BRCA cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg02574844 chr11:5959923 NA -0.44 -8.63 -0.32 4.74e-17 DNA methylation (variation); BRCA cis rs2370759 1.000 rs79442609 chr10:32608749 C/T cg01819863 chr10:32635814 EPC1 1.15 20.15 0.62 2.94e-70 Sexual dysfunction (female); BRCA cis rs1401999 0.659 rs4912518 chr3:183752027 C/T cg20387954 chr3:183756860 HTR3D -0.43 -10.07 -0.37 3.03e-22 Anterior chamber depth; BRCA cis rs7567389 0.704 rs4662714 chr2:127995213 A/G cg09760422 chr2:128146352 NA -0.4 -8.59 -0.32 6.5e-17 Self-rated health; BRCA cis rs7587476 0.906 rs3768713 chr2:215637505 G/A cg04004882 chr2:215674386 BARD1 0.59 10.36 0.38 2.31e-23 Neuroblastoma; BRCA cis rs6009527 0.711 rs8141990 chr22:49570455 T/G cg12746016 chr22:49560550 NA 0.41 9.67 0.36 9.92e-21 Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid); BRCA cis rs1165205 0.558 rs531750 chr6:25882642 C/G cg03517284 chr6:25882590 NA -0.96 -24.94 -0.7 2.04e-96 Urate levels; BRCA cis rs11984145 1.000 rs73121396 chr7:38870102 G/A cg19327137 chr7:38886074 VPS41 0.49 8.55 0.32 9.39e-17 Cognitive performance; BRCA cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg20503657 chr10:835505 NA 1.33 22.01 0.66 2.37e-80 Eosinophil percentage of granulocytes; BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.61 10.65 0.39 1.72e-24 Platelet count; BRCA cis rs13315871 0.929 rs79813245 chr3:58318475 G/A cg20936604 chr3:58311152 NA -0.65 -8.24 -0.31 9.48e-16 Cholesterol, total; BRCA trans rs11098499 0.663 rs28369503 chr4:120238925 G/A cg25214090 chr10:38739885 LOC399744 0.46 10.61 0.39 2.52e-24 Corneal astigmatism; BRCA cis rs9486719 0.947 rs11153071 chr6:97039741 G/A cg06623918 chr6:96969491 KIAA0776 -0.77 -13.51 -0.47 8.9e-37 Migraine;Coronary artery disease; BRCA cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg11279151 chr3:101281821 RG9MTD1 -0.48 -10.37 -0.38 2.21e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs3768617 0.811 rs34721094 chr1:183051521 T/C ch.1.3577855R chr1:183094577 LAMC1 0.46 10.09 0.37 2.5e-22 Fuchs's corneal dystrophy; BRCA cis rs10782582 0.593 rs11163967 chr1:76154185 T/C cg03433033 chr1:76189801 ACADM -0.47 -9.69 -0.36 8.06e-21 Daytime sleep phenotypes; BRCA cis rs1949733 0.877 rs940133 chr4:8473614 T/C cg13073564 chr4:8508604 NA -0.42 -10.82 -0.39 3.7e-25 Response to antineoplastic agents; BRCA cis rs7103648 0.695 rs12223593 chr11:47789082 T/G cg20307385 chr11:47447363 PSMC3 0.74 16.8 0.55 9.88e-53 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs4780401 0.609 rs8055247 chr16:11827543 G/A cg01061890 chr16:11836724 TXNDC11 -0.54 -12.54 -0.44 2.03e-32 Rheumatoid arthritis; BRCA cis rs7766436 0.583 rs988972 chr6:22558502 A/C cg13666174 chr6:22585274 NA -0.39 -7.81 -0.3 2.29e-14 Coronary artery disease; BRCA cis rs875971 0.756 rs4718328 chr7:65693337 A/G cg18876405 chr7:65276391 NA -0.51 -11.65 -0.42 1.38e-28 Aortic root size; BRCA cis rs7618501 0.633 rs55751738 chr3:49972101 A/G cg24308560 chr3:49941425 MST1R -0.4 -8.56 -0.32 8.62e-17 Intelligence (multi-trait analysis); BRCA cis rs769267 0.929 rs2905431 chr19:19482882 G/A cg26732615 chr19:19648335 CILP2;YJEFN3 -0.38 -8.31 -0.31 5.79e-16 Tonsillectomy; BRCA cis rs8031584 0.678 rs3122 chr15:31170290 A/T cg08704250 chr15:31115839 NA 0.48 12.94 0.46 3.34e-34 Huntington's disease progression; BRCA cis rs7811142 1.000 rs1000215 chr7:100004543 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.04 19.85 0.62 1.16e-68 Platelet count; BRCA cis rs9291683 0.588 rs12506364 chr4:10023448 C/T cg11266682 chr4:10021025 SLC2A9 0.49 13.21 0.46 2.18e-35 Bone mineral density; BRCA cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg12373951 chr3:133503437 NA 0.53 12.6 0.45 1.12e-32 Iron status biomarkers; BRCA cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg08219700 chr8:58056026 NA 0.46 8.39 0.32 3.01e-16 Developmental language disorder (linguistic errors); BRCA cis rs2576037 0.583 rs504668 chr18:44410749 T/C cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.62 14.43 0.5 4.46e-41 Personality dimensions; BRCA cis rs7666738 0.716 rs114187620 chr4:98819534 T/A cg17366294 chr4:99064904 C4orf37 0.44 10.22 0.37 8.18e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs28409322 chr3:134252385 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.82 0.62 1.64e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs28374715 0.662 rs28493087 chr15:41486504 G/A cg18705301 chr15:41695430 NDUFAF1 -0.87 -18.08 -0.58 2.61e-59 Ulcerative colitis; BRCA cis rs7615952 0.599 rs7652883 chr3:125707977 T/G cg18479299 chr3:125709523 NA -0.57 -9.13 -0.34 9.11e-19 Blood pressure (smoking interaction); BRCA cis rs897984 0.806 rs1458202 chr16:30953202 A/G cg00531865 chr16:30841666 NA -0.38 -8.96 -0.33 3.65e-18 Dementia with Lewy bodies; BRCA cis rs11677370 0.533 rs12711971 chr2:3820821 G/C cg17052675 chr2:3827356 NA -0.61 -15.54 -0.52 2.01e-46 Type 2 diabetes; BRCA cis rs11599315 0.757 rs11250392 chr10:1342543 T/C cg09624528 chr10:1369823 ADARB2 0.46 9.04 0.34 1.88e-18 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs6430585 0.591 rs309118 chr2:136746224 G/C cg07169764 chr2:136633963 MCM6 0.95 19.1 0.6 1.05e-64 Corneal structure; BRCA cis rs1941023 0.584 rs6591578 chr11:60158649 G/A cg08716584 chr11:60157161 MS4A7 -0.41 -9.25 -0.34 3.26e-19 Congenital heart disease (maternal effect); BRCA cis rs796364 0.806 rs11679676 chr2:201040981 C/T cg12253985 chr2:200820533 C2orf60;C2orf47 -0.62 -8.5 -0.32 1.31e-16 Schizophrenia; BRCA cis rs7586879 1.000 rs12713419 chr2:25121853 G/A cg01884057 chr2:25150051 NA 0.33 8.57 0.32 7.98e-17 Body mass index; BRCA cis rs13191362 1.000 rs35593345 chr6:163174981 G/C cg06582575 chr6:163149167 PACRG;PARK2 1.03 14.39 0.49 7.02e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12579753 0.872 rs7956132 chr12:82178709 A/G cg07988820 chr12:82153109 PPFIA2 -0.47 -7.9 -0.3 1.21e-14 Resting heart rate; BRCA cis rs6570726 0.935 rs365658 chr6:145844588 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.97 0.51 1.25e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs8032158 1.000 rs8032158 chr15:56194877 T/C cg02198044 chr15:56286336 NEDD4 -0.37 -8.98 -0.33 2.91e-18 Keloid; BRCA cis rs73001065 0.818 rs16996185 chr19:19720788 G/T cg03709012 chr19:19516395 GATAD2A -0.73 -9.48 -0.35 4.92e-20 LDL cholesterol; BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg03709012 chr19:19516395 GATAD2A 0.81 19.11 0.6 9.59e-65 Tonsillectomy; BRCA cis rs10208940 0.920 rs35005506 chr2:68814238 A/T cg12452813 chr2:68675892 NA 0.49 8.52 0.32 1.15e-16 Urate levels in lean individuals; BRCA cis rs1552244 1.000 rs67852463 chr3:10157205 G/C cg16606324 chr3:10149918 C3orf24 0.56 10.97 0.4 9.33e-26 Alzheimer's disease; BRCA cis rs7103648 1.000 rs2293579 chr11:47440758 G/A cg03711944 chr11:47377212 SPI1 -0.43 -11.16 -0.4 1.45e-26 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs250677 1.000 rs36080 chr5:148430451 A/G cg18129178 chr5:148520854 ABLIM3 -0.56 -11.56 -0.42 3.34e-28 Breast cancer; BRCA cis rs12477438 0.765 rs7571390 chr2:99626593 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.66 -15.95 -0.53 1.82e-48 Chronic sinus infection; BRCA cis rs2882667 0.690 rs1039788 chr5:138171501 G/A cg04439458 chr5:138467593 SIL1 0.31 7.81 0.3 2.44e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9467711 0.651 rs66790453 chr6:26107088 C/T cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.61 9.59 0.35 2e-20 Autism spectrum disorder or schizophrenia; BRCA cis rs2836974 0.897 rs35391055 chr21:40525516 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.73 0.6 1.05e-62 Cognitive function; BRCA trans rs2122469 0.655 rs17603934 chr8:20576344 A/G cg19996406 chr8:8318774 NA -0.35 -7.92 -0.3 1.06e-14 Serum tamsulosin hydrochloride concentration; BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.1 -0.31 2.71e-15 Total body bone mineral density; BRCA cis rs6723226 0.764 rs176403 chr2:32637864 C/A cg02381751 chr2:32503542 YIPF4 -0.73 -16.36 -0.54 1.56e-50 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg09184832 chr6:79620586 NA -0.52 -11.46 -0.41 8.98e-28 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs10021044 chr4:99002488 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.37e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7727544 0.735 rs272860 chr5:131684175 C/G cg24060327 chr5:131705240 SLC22A5 -0.49 -10.19 -0.37 1.09e-22 Blood metabolite levels; BRCA cis rs2204008 0.811 rs8189445 chr12:38276295 T/C cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.88e-18 Bladder cancer; BRCA cis rs9486719 0.947 rs2472893 chr6:96870048 G/C cg06623918 chr6:96969491 KIAA0776 0.74 12.98 0.46 2.34e-34 Migraine;Coronary artery disease; BRCA cis rs11098499 0.865 rs3956464 chr4:120256764 T/C cg09307838 chr4:120376055 NA 0.63 13.63 0.47 2.45e-37 Corneal astigmatism; BRCA cis rs7737355 0.853 rs1468453 chr5:130587459 A/C cg06307176 chr5:131281290 NA 0.45 8.8 0.33 1.3e-17 Life satisfaction; BRCA cis rs1862618 0.853 rs832569 chr5:56154584 T/A cg22800045 chr5:56110881 MAP3K1 0.66 12.28 0.44 2.9e-31 Initial pursuit acceleration; BRCA cis rs7617773 0.643 rs78159520 chr3:48349023 T/C cg11946769 chr3:48343235 NME6 0.7 14.26 0.49 2.94e-40 Coronary artery disease; BRCA trans rs7819412 0.745 rs4841498 chr8:10985432 C/T cg06636001 chr8:8085503 FLJ10661 -0.56 -12.05 -0.43 2.92e-30 Triglycerides; BRCA cis rs7786808 0.653 rs4909213 chr7:158202404 G/A cg01191920 chr7:158217561 PTPRN2 -0.34 -7.9 -0.3 1.23e-14 Obesity-related traits; BRCA cis rs2019137 0.905 rs2276561 chr2:113956371 G/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.59 -12.31 -0.44 2.1e-31 Lymphocyte counts; BRCA cis rs11098499 0.687 rs71610270 chr4:120287436 A/G cg09307838 chr4:120376055 NA 0.66 14.22 0.49 4.76e-40 Corneal astigmatism; BRCA cis rs826838 1.000 rs826886 chr12:39095797 A/G cg26384229 chr12:38710491 ALG10B 0.64 16.76 0.55 1.55e-52 Heart rate; BRCA cis rs765787 0.530 rs2413776 chr15:45544170 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.02 0.3 4.97e-15 Uric acid levels; BRCA cis rs16866061 0.962 rs3845840 chr2:225359100 G/A cg12698349 chr2:225449008 CUL3 0.77 21.13 0.64 1.54e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs4689388 0.782 rs4262051 chr4:6281775 G/A cg25554036 chr4:6271136 WFS1 0.44 10.46 0.38 9.8599999999999993e-24 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs977987 0.872 rs10781976 chr16:75314838 G/T cg03315344 chr16:75512273 CHST6 0.5 11.48 0.41 7.19e-28 Dupuytren's disease; BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg11578532 chr1:161008127 TSTD1 0.3 9.49 0.35 4.66e-20 Granulocyte percentage of myeloid white cells; BRCA cis rs4713118 0.824 rs742046 chr6:27739254 A/G cg20933634 chr6:27740509 NA 0.47 9.34 0.35 1.64e-19 Parkinson's disease; BRCA cis rs28735056 0.967 rs61090726 chr18:77631219 A/G cg20368463 chr18:77673604 PQLC1 -0.34 -8.0 -0.3 5.75e-15 Schizophrenia; BRCA cis rs9790314 0.846 rs9834659 chr3:160980947 A/C cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA cis rs7586879 0.681 rs6705446 chr2:25118608 T/C cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.26e-28 Body mass index; BRCA cis rs703842 0.616 rs1875125 chr12:58227241 T/G cg04478727 chr12:58166393 METTL1;FAM119B 0.5 8.77 0.33 1.6e-17 Multiple sclerosis; BRCA cis rs10992471 0.756 rs10115222 chr9:95128149 C/T cg13798575 chr9:95087839 CENPP;NOL8 0.33 7.87 0.3 1.57e-14 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs17376456 0.825 rs35426871 chr5:93291613 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.53 0.59 1.06e-61 Diabetic retinopathy; BRCA cis rs7523273 0.606 rs2796268 chr1:207925192 G/A cg22525895 chr1:207977042 MIR29B2 0.46 11.69 0.42 9.35e-29 Schizophrenia; BRCA cis rs12477438 0.520 rs13012481 chr2:99754290 C/A cg08885076 chr2:99613938 TSGA10 0.44 10.21 0.37 8.7e-23 Chronic sinus infection; BRCA cis rs72781680 0.821 rs17045981 chr2:24109316 A/G cg08917208 chr2:24149416 ATAD2B 0.67 10.91 0.4 1.57e-25 Lymphocyte counts; BRCA cis rs8062405 1.000 rs62037365 chr16:28868962 C/G cg09754948 chr16:28834200 ATXN2L 0.45 8.9 0.33 5.81e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10751667 0.666 rs7394992 chr11:980690 G/C ch.11.42038R chr11:967971 AP2A2 0.52 16.18 0.54 1.27e-49 Alzheimer's disease (late onset); BRCA cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg16482183 chr6:26056742 HIST1H1C 0.49 10.06 0.37 3.33e-22 Height; BRCA cis rs708547 0.874 rs1718868 chr4:57881215 G/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.5 11.94 0.43 8.09e-30 Response to bleomycin (chromatid breaks); BRCA cis rs6582630 0.502 rs11182760 chr12:38606273 A/T cg26384229 chr12:38710491 ALG10B 0.78 18.28 0.59 2.32e-60 Drug-induced liver injury (flucloxacillin); BRCA cis rs7560272 0.501 rs4852978 chr2:73943110 G/A cg20560298 chr2:73613845 ALMS1 0.34 8.59 0.32 6.44e-17 Schizophrenia; BRCA cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.01 -0.37 5.08e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs3809566 0.963 rs3809565 chr15:63333619 A/G cg12160578 chr15:63334699 TPM1 -0.46 -9.06 -0.34 1.62e-18 Platelet count; BRCA trans rs9388451 0.537 rs1739383 chr6:126098915 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.53 -12.91 -0.45 4.97e-34 Brugada syndrome; BRCA cis rs13118159 0.872 rs1882105 chr4:1345956 T/C cg16405210 chr4:1374714 KIAA1530 -0.61 -13.72 -0.48 9.35e-38 Longevity; BRCA cis rs2239547 0.522 rs6771610 chr3:53026104 T/C cg18404041 chr3:52824283 ITIH1 -0.3 -8.03 -0.3 4.74e-15 Schizophrenia; BRCA cis rs6430585 0.527 rs6753232 chr2:136436317 C/T cg07169764 chr2:136633963 MCM6 -0.93 -17.58 -0.57 9.57e-57 Corneal structure; BRCA trans rs7786808 0.707 rs10247026 chr7:158230595 C/T cg02030672 chr11:45687055 CHST1 0.39 8.19 0.31 1.46e-15 Obesity-related traits; BRCA trans rs2739330 0.828 rs2877178 chr22:24251517 C/T cg06437703 chr8:37914619 EIF4EBP1 -0.32 -8.37 -0.31 3.74e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs36051895 0.632 rs1581927 chr9:5177462 C/T cg02405213 chr9:5042618 JAK2 -0.47 -9.06 -0.34 1.52e-18 Pediatric autoimmune diseases; BRCA cis rs10540 1.000 rs12418639 chr11:473300 A/C cg03576123 chr11:487126 PTDSS2 1.16 17.31 0.57 2.38e-55 Body mass index; BRCA cis rs7772486 0.817 rs9386145 chr6:146363519 A/T cg13319975 chr6:146136371 FBXO30 -0.37 -8.56 -0.32 8.47e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs68170813 0.559 rs2107319 chr7:106863744 T/C cg02696742 chr7:106810147 HBP1 -0.48 -8.44 -0.32 2.06e-16 Coronary artery disease; BRCA cis rs858239 0.571 rs2390755 chr7:23190716 A/T cg23682824 chr7:23144976 KLHL7 0.42 11.04 0.4 4.49e-26 Cerebrospinal fluid biomarker levels; BRCA cis rs2276314 0.857 rs28435069 chr18:33628475 A/G cg05985134 chr18:33552581 C18orf21 0.65 12.41 0.44 7.63e-32 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs765787 0.530 rs2433229 chr15:45515235 C/A cg15395560 chr15:45543142 SLC28A2 0.3 8.37 0.31 3.69e-16 Uric acid levels; BRCA cis rs7309 0.622 rs4664396 chr2:161901650 C/T cg16506815 chr2:162101123 NA -0.44 -9.45 -0.35 6.14e-20 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs7811142 1.000 rs60257855 chr7:100026780 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.18 21.92 0.66 7.61e-80 Platelet count; BRCA cis rs3820928 0.605 rs6718767 chr2:227800776 A/G cg11843606 chr2:227700838 RHBDD1 -0.5 -11.48 -0.41 7.32e-28 Pulmonary function; BRCA cis rs7618915 0.501 rs2159644 chr3:52774530 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.19 0.4 1.17e-26 Bipolar disorder; BRCA trans rs6479891 1.000 rs12416349 chr10:65277543 C/T cg14819942 chr15:35414228 NA 0.35 8.51 0.32 1.28e-16 Arthritis (juvenile idiopathic); BRCA cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg23625390 chr15:77176239 SCAPER 0.39 9.06 0.34 1.61e-18 Blood metabolite levels; BRCA cis rs4665809 0.590 rs7586047 chr2:26447335 A/G cg25036284 chr2:26402008 FAM59B -0.89 -15.18 -0.51 1.1e-44 Gut microbiome composition (summer); BRCA cis rs2235642 0.893 rs2076442 chr16:1591112 G/T cg26528668 chr16:1614120 IFT140 0.38 8.6 0.32 6.27e-17 Coronary artery disease; BRCA cis rs921968 0.541 rs7583449 chr2:219403022 A/C cg02176678 chr2:219576539 TTLL4 -0.54 -13.54 -0.47 6.76e-37 Mean corpuscular hemoglobin concentration; BRCA cis rs17345786 1.000 rs7641261 chr3:101279006 C/T cg12386194 chr3:101231763 SENP7 0.62 11.97 0.43 6.48e-30 Colonoscopy-negative controls vs population controls; BRCA cis rs11764590 0.724 rs55789728 chr7:2107649 A/G cg02951883 chr7:2050386 MAD1L1 0.39 8.07 0.3 3.57e-15 Neuroticism; BRCA cis rs922182 0.538 rs16947599 chr15:64260944 C/T cg24729988 chr15:64271149 DAPK2 -0.6 -15.21 -0.52 8.08e-45 Blood protein levels; BRCA cis rs7552404 0.924 rs12136754 chr1:76230232 C/A cg10523679 chr1:76189770 ACADM 0.91 22.02 0.66 2.26e-80 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2011503 0.941 rs4808944 chr19:19426613 A/C cg11584989 chr19:19387371 SF4 0.66 14.26 0.49 2.94e-40 Bipolar disorder; BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg03188948 chr7:1209495 NA 0.53 9.72 0.36 6.17e-21 Longevity;Endometriosis; BRCA trans rs11098499 0.954 rs4345162 chr4:120312959 G/A cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA trans rs61931739 0.517 rs7313663 chr12:34417058 T/C cg26384229 chr12:38710491 ALG10B 0.58 13.17 0.46 3.35e-35 Morning vs. evening chronotype; BRCA cis rs67981189 0.896 rs3814871 chr14:71444788 G/A cg15816911 chr14:71606274 NA 0.35 7.9 0.3 1.25e-14 Schizophrenia; BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.63 13.38 0.47 3.75e-36 Lymphocyte counts; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.81 -0.33 1.2e-17 Total body bone mineral density; BRCA cis rs1552244 0.572 rs68013239 chr3:10165711 G/T cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs1059312 1.000 rs7135854 chr12:129279988 G/C cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.84 -0.53 6.63e-48 Systemic lupus erythematosus; BRCA cis rs367943 0.649 rs255866 chr5:112748532 A/T cg12552261 chr5:112820674 MCC 0.36 7.87 0.3 1.51e-14 Type 2 diabetes; BRCA cis rs1862618 0.715 rs6866779 chr5:56090000 G/A cg03609598 chr5:56110824 MAP3K1 -0.49 -8.03 -0.3 4.74e-15 Initial pursuit acceleration; BRCA cis rs2276314 0.857 rs28791905 chr18:33602213 G/A cg05985134 chr18:33552581 C18orf21 0.64 12.16 0.43 9.02e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs61931739 0.534 rs10844774 chr12:34166764 C/T cg06521331 chr12:34319734 NA -0.63 -11.49 -0.41 6.35e-28 Morning vs. evening chronotype; BRCA cis rs67981189 0.835 rs2526855 chr14:71413346 T/C cg15816911 chr14:71606274 NA -0.36 -8.02 -0.3 5.17e-15 Schizophrenia; BRCA cis rs2282802 0.685 rs12188849 chr5:139621570 G/A cg26211634 chr5:139558579 C5orf32 0.35 8.62 0.32 5.12e-17 Intelligence (multi-trait analysis); BRCA cis rs2760061 0.598 rs632832 chr1:228121838 G/T cg02753203 chr1:228287806 NA -0.59 -12.59 -0.45 1.29e-32 Diastolic blood pressure; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg22903471 chr2:27725779 GCKR -0.38 -9.38 -0.35 1.14e-19 Total body bone mineral density; BRCA cis rs9790314 0.586 rs16832279 chr3:161120483 C/T cg04691961 chr3:161091175 C3orf57 -0.38 -8.86 -0.33 7.65e-18 Morning vs. evening chronotype; BRCA cis rs765787 0.530 rs3759895 chr15:45543870 G/A cg15395560 chr15:45543142 SLC28A2 0.28 7.95 0.3 8.52e-15 Uric acid levels; BRCA cis rs780096 0.526 rs1647276 chr2:27688601 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.32 -8.47 -0.32 1.73e-16 Total body bone mineral density; BRCA cis rs9733 0.596 rs12403255 chr1:150660412 C/T cg18016565 chr1:150552671 MCL1 0.36 8.72 0.33 2.47e-17 Tonsillectomy; BRCA cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg08807101 chr21:30365312 RNF160 -0.59 -15.06 -0.51 4.22e-44 Dental caries; BRCA cis rs9467711 0.591 rs60512607 chr6:26054171 T/A cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.58 9.21 0.34 4.81e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg12479418 chr7:148823350 ZNF425;ZNF398 0.49 10.14 0.37 1.69e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6842047 0.563 rs6843711 chr4:187212953 T/C cg14349977 chr4:187219430 NA -0.61 -7.97 -0.3 7.05e-15 Blood protein levels; BRCA cis rs2836974 0.568 rs371625 chr21:40535271 A/G cg11890956 chr21:40555474 PSMG1 -0.85 -21.99 -0.66 3.23e-80 Cognitive function; BRCA cis rs10791323 0.569 rs10750541 chr11:133713189 A/C cg15485101 chr11:133734466 NA -0.4 -9.62 -0.36 1.56e-20 Childhood ear infection; BRCA cis rs881375 0.967 rs7039505 chr9:123705945 A/T cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 10.81 0.39 3.99e-25 Rheumatoid arthritis; BRCA cis rs2180341 0.960 rs1964130 chr6:127677391 C/G cg27446573 chr6:127587934 RNF146 0.86 18.16 0.58 1.02e-59 Breast cancer; BRCA cis rs875971 0.862 rs6460307 chr7:66060871 A/G cg18876405 chr7:65276391 NA 0.5 11.01 0.4 6.2e-26 Aortic root size; BRCA cis rs7552167 0.925 rs11249021 chr1:24512881 G/T cg01960748 chr1:24522592 NA -0.63 -10.93 -0.4 1.3e-25 Psoriasis vulgaris; BRCA cis rs2033711 0.870 rs3764534 chr19:58929136 G/A cg26874164 chr19:58962979 ZNF324B 0.44 9.3 0.35 2.28e-19 Uric acid clearance; BRCA cis rs11969893 0.649 rs1321204 chr6:101468591 A/G cg12253828 chr6:101329408 ASCC3 0.76 9.9 0.36 1.37e-21 Economic and political preferences (immigration/crime); BRCA cis rs1552244 1.000 rs67134728 chr3:10151431 G/C cg08888203 chr3:10149979 C3orf24 0.68 14.5 0.5 2.22e-41 Alzheimer's disease; BRCA cis rs9649213 0.555 rs6948346 chr7:97959956 A/G cg01877450 chr7:97915802 BRI3 -0.36 -8.19 -0.31 1.45e-15 Prostate cancer (SNP x SNP interaction); BRCA trans rs7618501 1.000 rs60205400 chr3:49800272 C/T cg21582582 chr3:182698605 DCUN1D1 0.39 10.16 0.37 1.38e-22 Intelligence (multi-trait analysis); BRCA cis rs10870270 0.957 rs3753008 chr10:133785129 A/C cg08754478 chr10:133766260 PPP2R2D -0.67 -13.85 -0.48 2.45e-38 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs9811920 0.809 rs793475 chr3:99543764 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -12.96 -0.46 2.9e-34 Axial length; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg03923535 chr7:1197113 ZFAND2A 0.52 11.18 0.4 1.31e-26 Longevity;Endometriosis; BRCA trans rs877282 0.945 rs17293517 chr10:778770 C/T cg22713356 chr15:30763199 NA 1.41 27.93 0.74 8.83e-113 Uric acid levels; BRCA cis rs12612619 0.732 rs2289360 chr2:27302165 T/C cg00617064 chr2:27272375 NA -0.33 -8.68 -0.32 3.32e-17 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs514406 0.893 rs512723 chr1:53343880 C/T cg24675658 chr1:53192096 ZYG11B 0.55 11.33 0.41 3.17e-27 Monocyte count; BRCA cis rs7631605 0.905 rs931721 chr3:37211972 T/C cg15934958 chr3:37212084 LRRFIP2 0.42 9.87 0.36 1.69e-21 Cerebrospinal P-tau181p levels; BRCA trans rs6582630 0.519 rs8189549 chr12:38245752 A/G cg06521331 chr12:34319734 NA -0.53 -9.51 -0.35 3.7e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs2070433 1.000 rs2070433 chr21:47961386 G/A cg12379764 chr21:47803548 PCNT 0.51 9.35 0.35 1.4e-19 Lymphocyte counts; BRCA cis rs8114671 0.562 rs6088642 chr20:33483186 G/T cg07148914 chr20:33460835 GGT7 0.38 8.58 0.32 7.26e-17 Height; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg08132940 chr7:1081526 C7orf50 -0.6 -9.02 -0.34 2.25e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs3809566 1.000 rs4775612 chr15:63332157 T/C cg05507819 chr15:63340323 TPM1 0.43 9.27 0.34 2.88e-19 Platelet count; BRCA cis rs6005807 0.719 rs12166245 chr22:28999890 C/T cg12565055 chr22:29076175 TTC28 0.5 9.38 0.35 1.17e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA trans rs1997103 1.000 rs10228182 chr7:55406695 A/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10504229 0.906 rs7842482 chr8:58167720 A/T cg05313129 chr8:58192883 C8orf71 -0.42 -8.85 -0.33 8.51e-18 Developmental language disorder (linguistic errors); BRCA cis rs8180040 0.966 rs1872164 chr3:47415100 G/A cg16586182 chr3:47516702 SCAP 0.65 15.13 0.51 1.93e-44 Colorectal cancer; BRCA cis rs2153535 0.580 rs9393016 chr6:8458573 T/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.9e-18 Motion sickness; BRCA cis rs6964587 0.626 rs4422709 chr7:91510968 A/G cg17063962 chr7:91808500 NA -0.53 -12.29 -0.44 2.63e-31 Breast cancer; BRCA cis rs17401966 0.800 rs12122029 chr1:10339822 G/A cg03954927 chr1:10346856 KIF1B 0.43 13.78 0.48 5.32e-38 Hepatocellular carcinoma; BRCA cis rs2842992 0.830 rs1535475 chr6:160148935 T/C cg19482086 chr6:160211437 TCP1;MRPL18 0.68 17.42 0.57 6.88e-56 Age-related macular degeneration (geographic atrophy); BRCA cis rs9399137 0.507 rs61738647 chr6:135282735 T/C cg24558204 chr6:135376177 HBS1L 0.59 15.86 0.53 5.13e-48 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs9527 0.545 rs10883847 chr10:104958284 C/T cg04362960 chr10:104952993 NT5C2 0.43 9.74 0.36 5.33e-21 Arsenic metabolism; BRCA cis rs72781680 0.611 rs72781699 chr2:24277709 G/A cg06627628 chr2:24431161 ITSN2 -0.52 -8.55 -0.32 9.28e-17 Lymphocyte counts; BRCA cis rs922182 0.557 rs2004231 chr15:64195769 C/T cg24729988 chr15:64271149 DAPK2 0.45 9.34 0.35 1.62e-19 Blood protein levels; BRCA cis rs929596 0.606 rs10178992 chr2:234657877 T/A cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -10.79 -0.39 4.79e-25 Total bilirubin levels in HIV-1 infection; BRCA cis rs12612619 0.732 rs10432697 chr2:27272052 T/C cg00617064 chr2:27272375 NA -0.32 -8.46 -0.32 1.83e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA trans rs11098499 0.908 rs28559989 chr4:120386627 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.91 0.45 4.95e-34 Corneal astigmatism; BRCA cis rs11105298 0.838 rs4842488 chr12:89881564 C/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.97 -0.37 7.48e-22 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs11098499 0.954 rs10017371 chr4:120293776 A/G cg25214090 chr10:38739885 LOC399744 0.55 12.36 0.44 1.33e-31 Corneal astigmatism; BRCA cis rs7646881 0.812 rs7624408 chr3:158460058 G/A cg19483011 chr3:158453295 NA -0.46 -8.05 -0.3 4.08e-15 Tetralogy of Fallot; BRCA cis rs13191362 0.935 rs35100164 chr6:162963003 T/C cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.76 0.45 2.24e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9814567 0.806 rs9824185 chr3:134324024 G/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.81 -0.3 2.42e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs7412746 0.658 rs2089082 chr1:150800090 T/G cg18016565 chr1:150552671 MCL1 0.34 7.95 0.3 8.56e-15 Melanoma; BRCA cis rs2276314 1.000 rs62101367 chr18:33550884 C/T cg05985134 chr18:33552581 C18orf21 0.71 13.49 0.47 1.16e-36 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2836974 0.644 rs11088471 chr21:40699313 A/G cg22974920 chr21:40686053 BRWD1 -0.41 -9.06 -0.34 1.58e-18 Cognitive function; BRCA cis rs11711311 0.955 rs10934247 chr3:113534941 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.52 -0.38 5.4e-24 IgG glycosylation; BRCA trans rs9329221 0.686 rs35406700 chr8:10244593 A/G cg06636001 chr8:8085503 FLJ10661 0.5 9.94 0.37 9.51e-22 Neuroticism; BRCA trans rs1994135 0.565 rs11052767 chr12:33731194 A/G cg26384229 chr12:38710491 ALG10B 0.47 9.93 0.37 1.07e-21 Resting heart rate; BRCA cis rs6542838 0.609 rs12712043 chr2:99541494 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.05 -0.34 1.66e-18 Fear of minor pain; BRCA cis rs4595586 0.545 rs1303887 chr12:39366523 C/T cg26384229 chr12:38710491 ALG10B 0.41 9.26 0.34 2.97e-19 Morning vs. evening chronotype; BRCA cis rs6750047 0.585 rs4670234 chr2:38272477 C/T cg07380506 chr2:38303506 CYP1B1 0.48 10.57 0.39 3.52e-24 Cutaneous malignant melanoma;Melanoma; BRCA cis rs881375 0.678 rs10818488 chr9:123705087 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.49 10.96 0.4 1e-25 Rheumatoid arthritis; BRCA cis rs1953600 0.870 rs12770550 chr10:81953451 G/T cg04850286 chr10:81895943 PLAC9 0.32 8.96 0.33 3.45e-18 Sarcoidosis; BRCA cis rs12134245 0.747 rs17501512 chr1:92012481 C/G cg21854759 chr1:92012499 NA 0.39 8.9 0.33 5.54e-18 Breast cancer; BRCA cis rs2576037 0.583 rs541634 chr18:44420271 C/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.61 14.1 0.49 1.71e-39 Personality dimensions; BRCA cis rs10193935 0.901 rs222468 chr2:42642531 C/T cg27598129 chr2:42591480 NA -0.76 -13.01 -0.46 1.66e-34 Colonoscopy-negative controls vs population controls; BRCA cis rs8180040 0.620 rs2305635 chr3:47043622 G/A cg16586182 chr3:47516702 SCAP 0.53 11.57 0.42 3.09e-28 Colorectal cancer; BRCA cis rs10256972 0.552 rs2960831 chr7:1201192 A/T cg03188948 chr7:1209495 NA 0.68 14.5 0.5 2.24e-41 Longevity;Endometriosis; BRCA cis rs10751667 0.600 rs10751672 chr11:948712 T/C cg10932868 chr11:921992 NA 0.5 12.8 0.45 1.56e-33 Alzheimer's disease (late onset); BRCA cis rs8005677 1.000 rs8006396 chr14:23380850 A/G cg01529538 chr14:23388837 RBM23 0.42 11.47 0.41 8.31e-28 Cognitive ability (multi-trait analysis); BRCA cis rs28735056 0.572 rs4799100 chr18:77640207 A/G cg20368463 chr18:77673604 PQLC1 -0.42 -10.65 -0.39 1.71e-24 Schizophrenia; BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg08888203 chr3:10149979 C3orf24 0.57 12.08 0.43 2.15e-30 Alzheimer's disease; BRCA cis rs9467773 1.000 rs2255070 chr6:26501777 C/G cg11502198 chr6:26597334 ABT1 0.47 9.43 0.35 7.5599999999999994e-20 Intelligence (multi-trait analysis); BRCA trans rs1459104 1.000 rs35097999 chr11:55048103 C/T cg03929089 chr4:120376271 NA 0.64 7.81 0.3 2.44e-14 Body mass index; BRCA cis rs6831352 0.879 rs7672728 chr4:100055173 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs36051895 0.695 rs10974916 chr9:5017350 G/A cg02405213 chr9:5042618 JAK2 -0.45 -8.38 -0.31 3.45e-16 Pediatric autoimmune diseases; BRCA cis rs12142240 0.698 rs1053627 chr1:46827728 A/C cg10495392 chr1:46806563 NSUN4 0.45 8.17 0.31 1.7e-15 Menopause (age at onset); BRCA cis rs2882667 0.690 rs288021 chr5:138224283 C/T cg04439458 chr5:138467593 SIL1 -0.34 -8.4 -0.32 2.91e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4689388 0.856 rs10016157 chr4:6294414 T/C cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7246967 0.673 rs12974988 chr19:22925965 G/T cg23217946 chr19:22817039 ZNF492 0.5 9.19 0.34 5.61e-19 Bronchopulmonary dysplasia; BRCA trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg25214090 chr10:38739885 LOC399744 0.53 12.03 0.43 3.51e-30 Corneal astigmatism; BRCA cis rs9611565 0.659 rs4822035 chr22:41935912 A/G cg06481639 chr22:41940642 POLR3H 0.48 7.92 0.3 1.03e-14 Vitiligo; BRCA cis rs3892630 0.817 rs35408716 chr19:33187961 A/C cg22980127 chr19:33182716 NUDT19 0.9 18.06 0.58 3.08e-59 Red blood cell traits; BRCA cis rs2439831 0.702 rs2788 chr15:44064886 A/G cg02155558 chr15:43621948 ADAL;LCMT2 0.68 11.85 0.42 2.03e-29 Lung cancer in ever smokers; BRCA cis rs1829883 0.898 rs2963578 chr5:98785417 C/T cg08333243 chr5:99726346 NA -0.34 -7.88 -0.3 1.45e-14 Hemostatic factors and hematological phenotypes; BRCA cis rs1941023 0.584 rs2197236 chr11:60168859 T/C cg08716584 chr11:60157161 MS4A7 -0.42 -9.73 -0.36 5.83e-21 Congenital heart disease (maternal effect); BRCA cis rs4805272 0.512 rs4805279 chr19:29336966 A/G cg04546413 chr19:29218101 NA 0.49 8.43 0.32 2.21e-16 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs7552404 0.924 rs1694419 chr1:76219801 C/T cg10523679 chr1:76189770 ACADM 0.74 16.98 0.56 1.25e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2153535 0.580 rs9505457 chr6:8479142 C/T cg21535247 chr6:8435926 SLC35B3 0.42 9.5 0.35 4.14e-20 Motion sickness; BRCA cis rs12477438 0.520 rs6741772 chr2:99738961 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 27.6 0.74 5.62e-111 Chronic sinus infection; BRCA cis rs8114671 0.562 rs6088653 chr20:33520321 T/C cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.07e-18 Height; BRCA cis rs7100689 0.784 rs3120977 chr10:82075324 C/G cg00277334 chr10:82204260 NA -0.42 -8.08 -0.3 3.14e-15 Post bronchodilator FEV1; BRCA cis rs7944584 0.632 rs7116451 chr11:47322327 G/A cg20307385 chr11:47447363 PSMC3 0.57 11.66 0.42 1.27e-28 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs813218 0.584 rs793469 chr3:99537305 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.39 -8.82 -0.33 1.07e-17 Orofacial clefts; BRCA cis rs7000551 0.532 rs4872486 chr8:22256359 G/T cg12081754 chr8:22256438 SLC39A14 0.78 15.94 0.53 2.18e-48 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs477895 0.713 rs3802933 chr11:63988102 C/T cg23719950 chr11:63933701 MACROD1 -0.55 -9.19 -0.34 5.65e-19 Mean platelet volume; BRCA cis rs6878727 0.962 rs10045630 chr5:123736235 C/T cg01806427 chr5:123737813 NA 0.42 9.31 0.35 2.08e-19 Breast cancer; BRCA cis rs3008870 1.000 rs1118393 chr1:67366668 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 20.93 0.64 1.71e-74 Lymphocyte percentage of white cells; BRCA cis rs9811920 0.609 rs13317017 chr3:99665521 A/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.72 -16.73 -0.55 2.24e-52 Axial length; BRCA cis rs17685 0.712 rs9800948 chr7:75810473 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.33 -0.31 4.99e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4332037 0.901 rs7791899 chr7:1935988 T/C cg02743256 chr7:2109353 MAD1L1 -0.45 -8.08 -0.3 3.31e-15 Bipolar disorder; BRCA cis rs9372253 1.000 rs2235989 chr6:110714584 A/T cg19196401 chr6:110721138 DDO -0.4 -10.08 -0.37 2.92e-22 Platelet distribution width; BRCA cis rs1552244 1.000 rs112847840 chr3:10101652 C/T cg00166722 chr3:10149974 C3orf24 0.66 13.26 0.46 1.33e-35 Alzheimer's disease; BRCA cis rs9790314 0.747 rs9990242 chr3:160838461 T/C cg04691961 chr3:161091175 C3orf57 -0.46 -9.89 -0.36 1.44e-21 Morning vs. evening chronotype; BRCA cis rs6815814 0.950 rs5743557 chr4:38806827 G/A cg02016764 chr4:38805732 TLR1 -0.6 -9.56 -0.35 2.42e-20 Breast cancer; BRCA cis rs13191362 0.935 rs67337490 chr6:162953961 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.77 11.22 0.41 8.98e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9858542 0.953 rs10640 chr3:49454277 G/A cg03060546 chr3:49711283 APEH -0.53 -10.51 -0.38 6.38e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9486719 1.000 rs13207333 chr6:96882254 T/C cg06623918 chr6:96969491 KIAA0776 -0.73 -12.95 -0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs738322 0.533 rs5756934 chr22:38547279 G/A cg25457927 chr22:38595422 NA -0.37 -13.18 -0.46 2.8e-35 Cutaneous nevi; BRCA cis rs7666738 0.830 rs11944107 chr4:98931638 G/C cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs55665837 1.000 rs10832268 chr11:14465068 C/A cg19336497 chr11:14380999 RRAS2 -0.37 -9.77 -0.36 4.22e-21 Vitamin D levels; BRCA cis rs13217239 0.646 rs10946897 chr6:26995251 A/C cg12292205 chr6:26970375 C6orf41 0.58 12.87 0.45 7.13e-34 Schizophrenia; BRCA cis rs312274 0.550 rs10879360 chr12:41313575 A/C cg17827154 chr12:41323612 CNTN1 -0.42 -10.51 -0.38 6.02e-24 Metabolite levels (X-11787); BRCA cis rs2204008 0.666 rs67792345 chr12:38204698 T/C cg26384229 chr12:38710491 ALG10B 0.75 16.26 0.54 5.37e-50 Bladder cancer; BRCA cis rs7772486 0.790 rs2265917 chr6:146212285 A/G cg23711669 chr6:146136114 FBXO30 0.75 17.37 0.57 1.18e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs17711722 0.523 rs365896 chr7:65510697 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.5 -10.96 -0.4 9.9e-26 Calcium levels; BRCA trans rs4650994 1.000 rs12138561 chr1:178518784 G/T cg05059571 chr16:84539110 KIAA1609 -0.43 -9.61 -0.36 1.6e-20 HDL cholesterol levels;HDL cholesterol; BRCA cis rs11955398 0.584 rs62372964 chr5:59885798 C/A cg02684056 chr5:59996105 DEPDC1B 0.35 8.33 0.31 4.78e-16 Intelligence (multi-trait analysis); BRCA cis rs79839061 0.610 rs9994159 chr4:891150 C/T cg14530993 chr4:882597 GAK 0.57 10.16 0.37 1.36e-22 Intelligence (multi-trait analysis); BRCA cis rs6963495 0.818 rs56251768 chr7:105165591 A/G cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA cis rs7811142 0.830 rs41280971 chr7:99954457 G/T cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.54 8.7 0.33 2.75e-17 Platelet count; BRCA trans rs3942852 0.774 rs10838811 chr11:48186795 A/G cg03929089 chr4:120376271 NA -0.48 -9.02 -0.34 2.1e-18 Acute lymphoblastic leukemia (childhood); BRCA cis rs10911251 0.508 rs729672 chr1:183109236 G/A ch.1.3577855R chr1:183094577 LAMC1 0.63 16.06 0.54 5.01e-49 Colorectal cancer; BRCA cis rs1552244 0.935 rs7652190 chr3:10105150 G/A cg08888203 chr3:10149979 C3orf24 0.67 14.07 0.49 2.26e-39 Alzheimer's disease; BRCA cis rs6665290 0.669 rs3738725 chr1:227174210 T/C cg10327440 chr1:227177885 CDC42BPA -1.09 -38.64 -0.84 2.5e-169 Myeloid white cell count; BRCA cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7666738 0.830 rs1813642 chr4:98852225 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.89 0.51 2.75e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs780096 0.545 rs11695549 chr2:27586155 A/C cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.52 -0.32 1.18e-16 Total body bone mineral density; BRCA cis rs6762477 0.748 rs11711407 chr3:50225029 A/G cg05623727 chr3:50126028 RBM5 -0.39 -9.04 -0.34 1.89e-18 Menarche (age at onset); BRCA cis rs10791323 0.593 rs10791329 chr11:133716356 T/C cg14349672 chr11:133703707 NA -0.41 -9.15 -0.34 7.55e-19 Childhood ear infection; BRCA cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg12935359 chr14:103987150 CKB -0.56 -13.13 -0.46 4.85e-35 Body mass index; BRCA cis rs7772486 0.790 rs9376968 chr6:146180364 T/C cg05347473 chr6:146136440 FBXO30 0.4 8.12 0.31 2.48e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 0.752 rs4607935 chr1:46117161 C/T cg03146154 chr1:46216737 IPP 0.52 11.59 0.42 2.54e-28 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs9660992 0.710 rs1668873 chr1:205235990 G/A cg21545522 chr1:205238299 TMCC2 0.4 8.79 0.33 1.39e-17 Mean corpuscular volume;Mean platelet volume; BRCA cis rs8177253 0.829 rs9882812 chr3:133506127 A/G cg11941060 chr3:133502564 NA -0.59 -14.24 -0.49 3.47e-40 Iron status biomarkers; BRCA trans rs3857536 0.776 rs9342535 chr6:66932963 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.11 -0.31 2.53e-15 Blood trace element (Cu levels); BRCA cis rs7647973 0.626 rs1586827 chr3:49671224 T/C cg03060546 chr3:49711283 APEH 0.61 10.33 0.38 3.17e-23 Menarche (age at onset); BRCA cis rs9381040 0.610 rs2268191 chr6:41027653 G/C cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -9.97 -0.37 7.37e-22 Alzheimer's disease (late onset); BRCA cis rs1003719 0.591 rs13046303 chr21:38551976 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.57 -13.08 -0.46 8.12e-35 Eye color traits; BRCA cis rs3008870 1.000 rs2985797 chr1:67431499 C/T cg08660285 chr1:67390436 MIER1;WDR78 -0.97 -20.82 -0.64 6.59e-74 Lymphocyte percentage of white cells; BRCA cis rs1552244 0.572 rs59132826 chr3:10169725 G/A cg08888203 chr3:10149979 C3orf24 0.64 11.9 0.43 1.24e-29 Alzheimer's disease; BRCA cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg02659138 chr7:134003124 SLC35B4 0.33 10.38 0.38 1.95e-23 Mean platelet volume; BRCA cis rs7618915 0.571 rs1961959 chr3:52585760 G/C cg10802521 chr3:52805072 NEK4 -0.32 -8.22 -0.31 1.13e-15 Bipolar disorder; BRCA cis rs7666738 0.830 rs13112131 chr4:98976784 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs3858526 0.833 rs4758184 chr11:5926719 A/G cg25319279 chr11:5960081 NA -0.41 -7.91 -0.3 1.17e-14 DNA methylation (variation); BRCA cis rs9403521 1.000 rs9390126 chr6:143980432 A/G cg18240653 chr6:144019428 PHACTR2 -0.41 -8.18 -0.31 1.48e-15 Obesity-related traits; BRCA cis rs9381040 0.610 rs9381028 chr6:41025081 C/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.0 -0.37 5.53e-22 Alzheimer's disease (late onset); BRCA cis rs7607369 0.536 rs12623740 chr2:219665715 T/A cg02176678 chr2:219576539 TTLL4 -0.37 -9.42 -0.35 8.09e-20 Red blood cell count;Amyotrophic lateral sclerosis; BRCA cis rs829883 0.902 rs1620317 chr12:98890566 T/C cg25150519 chr12:98850993 NA 0.59 11.88 0.43 1.52e-29 Colorectal adenoma (advanced); BRCA cis rs17376456 0.877 rs12374488 chr5:93481407 A/G cg25358565 chr5:93447407 FAM172A 1.24 19.13 0.6 7.41e-65 Diabetic retinopathy; BRCA cis rs2836974 0.545 rs8128901 chr21:40710419 G/A cg17971929 chr21:40555470 PSMG1 0.52 11.64 0.42 1.49e-28 Cognitive function; BRCA cis rs4665809 0.941 rs2289021 chr2:26362515 A/C cg25036284 chr2:26402008 FAM59B 0.59 9.8 0.36 3.35e-21 Gut microbiome composition (summer); BRCA cis rs2624839 0.704 rs2624838 chr3:50205642 C/G cg24110177 chr3:50126178 RBM5 -0.4 -10.32 -0.38 3.38e-23 Intelligence (multi-trait analysis); BRCA cis rs1218582 0.741 rs10908444 chr1:154840287 G/A cg06221963 chr1:154839813 KCNN3 -0.57 -16.07 -0.54 4.89e-49 Prostate cancer; BRCA cis rs4595586 0.756 rs1400283 chr12:39364596 G/C cg26384229 chr12:38710491 ALG10B 0.39 8.59 0.32 6.65e-17 Morning vs. evening chronotype; BRCA cis rs9788682 0.747 rs2568499 chr15:78722359 T/C cg24631222 chr15:78858424 CHRNA5 -0.49 -9.6 -0.36 1.75e-20 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio; BRCA cis rs3733585 0.605 rs4697708 chr4:10121189 A/G cg11266682 chr4:10021025 SLC2A9 -0.4 -9.93 -0.37 1.01e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs8180040 0.654 rs13078131 chr3:47204939 G/T cg27129171 chr3:47204927 SETD2 0.75 19.53 0.61 5.98e-67 Colorectal cancer; BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg00166722 chr3:10149974 C3orf24 0.64 12.62 0.45 9.76e-33 Alzheimer's disease; BRCA cis rs763121 0.853 rs5757232 chr22:39071677 C/T cg14440974 chr22:39074834 NA -0.38 -9.09 -0.34 1.24e-18 Menopause (age at onset); BRCA cis rs11608355 0.545 rs1073779 chr12:109894721 C/T cg05360138 chr12:110035743 NA 0.71 13.18 0.46 2.85e-35 Neuroticism; BRCA trans rs4427176 0.507 rs7010270 chr8:9556847 C/T cg22064581 chr6:34113293 NA 0.34 8.16 0.31 1.83e-15 Mosquito bite size; BRCA trans rs9291683 0.546 rs7442336 chr4:10045783 G/A cg26043149 chr18:55253948 FECH 0.4 8.73 0.33 2.17e-17 Bone mineral density; BRCA cis rs17401966 0.838 rs55676616 chr1:10290126 T/C cg03954927 chr1:10346856 KIF1B 0.43 13.68 0.48 1.56e-37 Hepatocellular carcinoma; BRCA trans rs2204008 0.744 rs8189486 chr12:38244968 C/T cg06521331 chr12:34319734 NA -0.53 -9.51 -0.35 3.7e-20 Bladder cancer; BRCA cis rs11711311 1.000 rs11719303 chr3:113494524 A/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -9.98 -0.37 6.55e-22 IgG glycosylation; BRCA cis rs17253792 0.822 rs10135426 chr14:56054644 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.57 7.98 0.3 6.98e-15 Putamen volume; BRCA cis rs514406 0.505 rs387436 chr1:53179376 C/T cg24675658 chr1:53192096 ZYG11B 0.64 14.15 0.49 9.68e-40 Monocyte count; BRCA cis rs1153858 0.621 rs2413769 chr15:45561868 A/C cg14582100 chr15:45693742 SPATA5L1 0.3 8.96 0.33 3.63e-18 Homoarginine levels; BRCA cis rs1865760 0.688 rs9379814 chr6:25979869 C/T cg17691542 chr6:26056736 HIST1H1C 0.49 10.16 0.37 1.38e-22 Height; BRCA cis rs2404602 0.716 rs12907805 chr15:76690606 C/T cg22467129 chr15:76604101 ETFA -0.49 -10.83 -0.39 3.42e-25 Blood metabolite levels; BRCA trans rs208520 0.690 rs12201219 chr6:66748862 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.89 0.64 3.01e-74 Exhaled nitric oxide output; BRCA cis rs4481887 0.772 rs4916127 chr1:248466615 A/G cg13385794 chr1:248469461 NA 0.28 7.81 0.3 2.28e-14 Common traits (Other); BRCA cis rs736408 0.812 rs4687654 chr3:52827566 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.31 9.56 0.35 2.59e-20 Bipolar disorder; BRCA cis rs7301016 0.846 rs11174571 chr12:63022329 C/T cg01804193 chr12:63026212 NA 0.47 8.31 0.31 5.61e-16 IgG glycosylation; BRCA cis rs6964587 0.869 rs4729010 chr7:91486751 G/A cg17063962 chr7:91808500 NA -0.54 -12.92 -0.45 4.51e-34 Breast cancer; BRCA trans rs4650994 0.525 rs2761463 chr1:178557137 T/C cg05059571 chr16:84539110 KIAA1609 0.57 12.78 0.45 1.82e-33 HDL cholesterol levels;HDL cholesterol; BRCA cis rs6121246 0.609 rs6060843 chr20:30297047 G/C cg13852791 chr20:30311386 BCL2L1 0.89 20.13 0.62 3.67e-70 Mean corpuscular hemoglobin; BRCA cis rs12477438 0.798 rs1453562 chr2:99615850 G/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs950169 0.580 rs11634320 chr15:85172183 A/C cg11189052 chr15:85197271 WDR73 -0.42 -8.82 -0.33 1.09e-17 Schizophrenia; BRCA cis rs4689388 0.926 rs10937718 chr4:6295217 T/C cg25554036 chr4:6271136 WFS1 0.43 10.02 0.37 4.67e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs2562456 0.876 rs11085467 chr19:21751843 A/G cg25042112 chr7:64838748 ZNF92 -0.45 -8.46 -0.32 1.84e-16 Pain; BRCA cis rs3733585 0.657 rs62286568 chr4:10124889 C/T cg11266682 chr4:10021025 SLC2A9 -0.38 -9.5 -0.35 3.97e-20 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs747782 0.527 rs75915859 chr11:48232931 C/T cg15704280 chr7:45808275 SEPT13 0.56 8.04 0.3 4.24e-15 Intraocular pressure; BRCA cis rs1580019 0.563 rs896137 chr7:32579345 G/T cg07520158 chr7:32535189 LSM5;AVL9 0.48 10.38 0.38 2.01e-23 Cognitive ability; BRCA cis rs6733011 0.578 rs6714243 chr2:99510039 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.35 -8.01 -0.3 5.59e-15 Bipolar disorder; BRCA cis rs11920090 0.932 rs2292621 chr3:170723668 C/T cg09710316 chr3:170744871 SLC2A2 0.41 7.93 0.3 1.02e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs7568458 0.684 rs7579147 chr2:85805654 G/A cg02493740 chr2:85810744 VAMP5 -0.56 -11.31 -0.41 3.8e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9815354 0.812 rs77732985 chr3:41945872 G/A cg03022575 chr3:42003672 ULK4 0.68 9.49 0.35 4.64e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs11690935 0.549 rs62183819 chr2:172904520 G/T cg13550731 chr2:172543902 DYNC1I2 0.58 14.51 0.5 1.86e-41 Schizophrenia; BRCA cis rs1552244 0.882 rs13084194 chr3:10031492 T/A cg02579736 chr3:10068473 FANCD2;CIDECP 0.86 14.46 0.5 3.43e-41 Alzheimer's disease; BRCA cis rs12681288 0.676 rs34282191 chr8:991290 G/A cg04851639 chr8:1020857 NA -0.36 -9.96 -0.37 7.9e-22 Schizophrenia; BRCA cis rs704795 0.836 rs1083865 chr2:27620827 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.31e-16 Menopause (age at onset); BRCA cis rs870825 0.860 rs60022249 chr4:185600772 T/C cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs12477438 0.798 rs6542849 chr2:99578493 G/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.72 -0.5 1.95e-42 Chronic sinus infection; BRCA cis rs7772486 0.686 rs702305 chr6:145973840 A/G cg23711669 chr6:146136114 FBXO30 -0.72 -17.06 -0.56 4.95e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs7727544 0.631 rs13357280 chr5:131600187 A/G cg14196790 chr5:131705035 SLC22A5 0.43 11.2 0.41 1.04e-26 Blood metabolite levels; BRCA cis rs7552404 0.690 rs12723575 chr1:76335203 T/C cg03433033 chr1:76189801 ACADM -0.6 -12.27 -0.44 3.15e-31 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4862750 0.872 rs13110072 chr4:187878524 A/G cg22105103 chr4:187893119 NA 0.41 13.28 0.47 1.03e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs4808199 1.000 rs17288409 chr19:19504167 T/C cg03709012 chr19:19516395 GATAD2A 1.1 21.37 0.65 7.05e-77 Nonalcoholic fatty liver disease; BRCA cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg05283184 chr6:79620031 NA -0.35 -8.21 -0.31 1.27e-15 Intelligence (multi-trait analysis); BRCA cis rs7617480 0.610 rs4955420 chr3:49208865 A/G cg03060546 chr3:49711283 APEH 0.47 10.11 0.37 2.25e-22 Subjective well-being (multi-trait analysis);Menarche (age at onset); BRCA cis rs6460942 1.000 rs62448568 chr7:12407445 A/G cg06484146 chr7:12443880 VWDE -0.72 -9.97 -0.37 7.58e-22 Coronary artery disease; BRCA cis rs2882667 0.654 rs7709770 chr5:138149339 A/G cg04439458 chr5:138467593 SIL1 0.36 8.64 0.32 4.57e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4919694 1.000 rs58700372 chr10:104800205 T/C cg04362960 chr10:104952993 NT5C2 0.94 14.5 0.5 2.26e-41 Arsenic metabolism; BRCA cis rs12477438 0.501 rs11685756 chr2:99766215 T/C cg08885076 chr2:99613938 TSGA10 0.46 10.93 0.4 1.36e-25 Chronic sinus infection; BRCA cis rs2836974 0.602 rs2836987 chr21:40706594 C/T cg11890956 chr21:40555474 PSMG1 -0.8 -18.85 -0.6 2.33e-63 Cognitive function; BRCA cis rs769267 0.896 rs7253807 chr19:19631444 A/T cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.04 0.34 1.92e-18 Tonsillectomy; BRCA cis rs875971 0.571 rs160641 chr7:65577346 G/A cg11764359 chr7:65958608 NA -0.65 -11.91 -0.43 1.15e-29 Aortic root size; BRCA cis rs2066819 1.000 rs17118439 chr12:56667604 C/T cg26714650 chr12:56694279 CS 1.11 14.9 0.51 2.46e-43 Psoriasis vulgaris; BRCA cis rs6546550 0.901 rs3771531 chr2:70164034 T/C cg02498382 chr2:70120550 SNRNP27 -0.51 -11.14 -0.4 1.76e-26 Prevalent atrial fibrillation; BRCA cis rs9359856 0.564 rs76069351 chr6:90425043 C/T cg13799429 chr6:90582589 CASP8AP2 -0.69 -8.22 -0.31 1.15e-15 Bipolar disorder; BRCA cis rs7524258 0.903 rs4908450 chr1:7292756 T/C cg07173049 chr1:7289937 CAMTA1 0.55 13.54 0.47 6.48e-37 Tourette's syndrome or obsessive-compulsive disorder; BRCA cis rs2015599 0.549 rs3782508 chr12:29451379 T/G cg09582351 chr12:29534625 ERGIC2 -0.34 -7.82 -0.3 2.21e-14 Mean platelet volume;Platelet count; BRCA cis rs778371 0.723 rs6739794 chr2:233576165 G/A cg08000102 chr2:233561755 GIGYF2 0.82 20.01 0.62 1.6e-69 Schizophrenia; BRCA cis rs78456975 1.000 rs10192959 chr2:1553393 G/T cg26248373 chr2:1572462 NA -0.51 -9.82 -0.36 2.63e-21 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs13191362 0.507 rs1954810 chr6:163061749 C/T cg21926612 chr6:163149169 PACRG;PARK2 -0.51 -9.88 -0.36 1.58e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs11971779 0.715 rs7787398 chr7:139061846 A/G cg07862535 chr7:139043722 LUC7L2 0.4 10.75 0.39 7.08e-25 Diisocyanate-induced asthma; BRCA cis rs4363385 0.818 rs407448 chr1:153007504 C/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.55 -0.32 9.31e-17 Inflammatory skin disease; BRCA cis rs9790314 0.690 rs6783085 chr3:160830929 A/G cg03342759 chr3:160939853 NMD3 -0.53 -11.33 -0.41 3.02e-27 Morning vs. evening chronotype; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg27170947 chr2:26402098 FAM59B -0.64 -11.25 -0.41 6.3100000000000004e-27 Gut microbiome composition (summer); BRCA cis rs4665809 0.556 rs6730311 chr2:26419474 C/T cg25036284 chr2:26402008 FAM59B -0.88 -15.49 -0.52 3.43e-46 Gut microbiome composition (summer); BRCA cis rs113835537 0.529 rs11227509 chr11:66281194 T/C cg24851651 chr11:66362959 CCS 0.44 8.29 0.31 6.92e-16 Airway imaging phenotypes; BRCA cis rs2624839 0.704 rs2624833 chr3:50212512 G/T cg05623727 chr3:50126028 RBM5 0.39 8.3 0.31 6.09e-16 Intelligence (multi-trait analysis); BRCA cis rs9443645 0.810 rs7753531 chr6:79789996 A/C cg09184832 chr6:79620586 NA -0.48 -10.35 -0.38 2.54e-23 Intelligence (multi-trait analysis); BRCA cis rs6763687 0.637 rs7620170 chr3:171808897 A/G cg16233210 chr3:171778391 FNDC3B 0.37 8.77 0.33 1.61e-17 Red cell distribution width; BRCA cis rs4642101 0.662 rs57411588 chr3:12820384 C/G cg24848339 chr3:12840334 CAND2 0.49 13.14 0.46 4.22e-35 QRS complex (12-leadsum); BRCA cis rs2882667 0.690 rs288041 chr5:138204011 T/C cg04439458 chr5:138467593 SIL1 -0.31 -7.94 -0.3 8.86e-15 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs9291683 0.530 rs35908990 chr4:9976105 G/A cg11266682 chr4:10021025 SLC2A9 0.41 10.82 0.39 3.7e-25 Bone mineral density; BRCA cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg12311346 chr5:56204834 C5orf35 -0.83 -16.32 -0.54 2.49e-50 Initial pursuit acceleration; BRCA cis rs13031619 0.950 rs7589966 chr2:3696636 A/G cg19052272 chr2:3704530 ALLC 0.48 10.35 0.38 2.58e-23 Response to inhaled corticosteroid treatment in asthma (change in FEV1); BRCA cis rs801193 0.660 rs1016265 chr7:66214567 C/T cg18876405 chr7:65276391 NA 0.52 12.19 0.43 7e-31 Aortic root size; BRCA trans rs7395662 0.525 rs1945189 chr11:48418889 A/G cg00717180 chr2:96193071 NA -0.38 -10.2 -0.37 9.48e-23 HDL cholesterol; BRCA cis rs873946 0.648 rs12767283 chr10:134557094 C/G cg27286337 chr10:134555280 INPP5A 0.8 12.94 0.46 3.49e-34 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs881375 0.967 rs1860823 chr9:123659304 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.43 8.51 0.32 1.21e-16 Rheumatoid arthritis; BRCA cis rs490234 0.934 rs7865246 chr9:128269511 T/C cg14078157 chr9:128172775 NA -0.33 -7.91 -0.3 1.13e-14 Mean arterial pressure; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg12564285 chr5:131593104 PDLIM4 0.37 9.98 0.37 6.59e-22 Breast cancer; BRCA cis rs6430585 0.528 rs309167 chr2:136669264 C/T cg07169764 chr2:136633963 MCM6 1.06 19.98 0.62 2.22e-69 Corneal structure; BRCA cis rs17401966 1.000 rs17401966 chr1:10385471 C/T cg15208524 chr1:10270712 KIF1B -0.38 -8.11 -0.31 2.56e-15 Hepatocellular carcinoma; BRCA cis rs10504073 0.669 rs341801 chr8:50037784 A/G cg00325661 chr8:49890786 NA 0.38 10.87 0.39 2.36e-25 Blood metabolite ratios; BRCA cis rs2625529 0.689 rs10851847 chr15:72111760 T/C cg16672083 chr15:72433130 SENP8 -0.65 -15.31 -0.52 2.61e-45 Red blood cell count; BRCA cis rs7772486 0.875 rs2777479 chr6:146309178 C/A cg23711669 chr6:146136114 FBXO30 0.65 14.66 0.5 3.86e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs2011503 0.739 rs10412176 chr19:19689164 T/C cg15839431 chr19:19639596 YJEFN3 0.38 8.44 0.32 2.07e-16 Bipolar disorder; BRCA cis rs477895 1.000 rs34292685 chr11:64049021 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.67 9.23 0.34 3.96e-19 Mean platelet volume; BRCA cis rs7599312 0.963 rs6735267 chr2:213403863 C/T cg20637307 chr2:213403960 ERBB4 0.49 9.86 0.36 1.91e-21 BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1577917 0.804 rs2786854 chr6:86668740 C/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.33 -8.92 -0.33 5.04e-18 Response to antipsychotic treatment; BRCA cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg05347473 chr6:146136440 FBXO30 -0.4 -8.01 -0.3 5.45e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2019137 0.868 rs6755639 chr2:113981810 A/G cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.54 11.53 0.41 4.62e-28 Lymphocyte counts; BRCA cis rs1843834 0.505 rs940317 chr2:225358118 C/T cg22509189 chr2:225307070 NA -0.46 -9.93 -0.37 1.07e-21 IgE levels in asthmatics (D.p. specific); BRCA cis rs1878931 0.726 rs3843728 chr16:3448251 T/C cg26668626 chr16:3451006 ZNF174;ZNF434 1.0 26.91 0.73 3.15e-107 Body mass index (adult); BRCA cis rs10504229 0.683 rs56058640 chr8:58128862 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.63 14.08 0.49 2.02e-39 Platelet count; BRCA cis rs9487051 0.802 rs6568558 chr6:109592701 A/T cg21918786 chr6:109611834 NA -0.46 -12.9 -0.45 5.56e-34 Reticulocyte fraction of red cells; BRCA cis rs7568458 0.527 rs35416445 chr2:85773659 A/G cg02493740 chr2:85810744 VAMP5 -0.54 -11.23 -0.41 8.17e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs312273 0.589 rs278919 chr12:41378355 C/T cg17827154 chr12:41323612 CNTN1 0.39 10.28 0.38 4.91e-23 Bipolar disorder; BRCA cis rs2836950 0.565 rs2836930 chr21:40545656 A/G cg17971929 chr21:40555470 PSMG1 -0.49 -10.88 -0.4 2.11e-25 Menarche (age at onset); BRCA cis rs881375 0.692 rs2072438 chr9:123651301 T/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.46 9.38 0.35 1.16e-19 Rheumatoid arthritis; BRCA trans rs208520 0.802 rs208516 chr6:66946119 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.89 -16.45 -0.55 5.68e-51 Exhaled nitric oxide output; BRCA cis rs1008375 0.966 rs3796813 chr4:17591648 A/G cg04450456 chr4:17643702 FAM184B 0.4 11.92 0.43 1.03e-29 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs898097 0.528 rs2243523 chr17:80680449 G/T cg05255149 chr17:80675120 FN3KRP -0.44 -9.2 -0.34 4.94e-19 Breast cancer; BRCA cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg05623727 chr3:50126028 RBM5 0.42 9.73 0.36 6.07e-21 Intelligence (multi-trait analysis); BRCA cis rs10256972 0.521 rs10280960 chr7:1103697 A/G cg18765753 chr7:1198926 ZFAND2A -0.36 -8.75 -0.33 1.94e-17 Longevity;Endometriosis; BRCA cis rs941873 0.805 rs10824747 chr10:81118464 T/C cg09469691 chr10:81107165 PPIF 0.5 10.16 0.37 1.4e-22 Height; BRCA cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg08280861 chr8:58055591 NA 0.52 8.51 0.32 1.25e-16 Developmental language disorder (linguistic errors); BRCA cis rs2625529 0.557 rs1000281 chr15:72553422 A/G cg16672083 chr15:72433130 SENP8 0.6 14.45 0.5 3.84e-41 Red blood cell count; BRCA cis rs6951245 0.554 rs11544331 chr7:1131411 C/T cg23708337 chr7:1209742 NA 0.54 8.83 0.33 1.02e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs67460515 0.529 rs11712713 chr3:160852471 A/G cg03342759 chr3:160939853 NMD3 -0.59 -11.9 -0.43 1.29e-29 Parkinson's disease; BRCA cis rs897984 0.609 rs11862744 chr16:31057800 G/A cg02466173 chr16:30829666 NA -0.42 -9.36 -0.35 1.39e-19 Dementia with Lewy bodies; BRCA cis rs28595532 0.920 rs112016126 chr4:119726528 C/T cg11846333 chr4:119757529 SEC24D 0.59 7.82 0.3 2.22e-14 Cannabis dependence symptom count; BRCA cis rs7267979 1.000 rs6037095 chr20:25335687 A/G cg08601574 chr20:25228251 PYGB -0.35 -8.56 -0.32 8.27e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6598955 0.671 rs7544 chr1:26607726 T/G cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs10504229 0.683 rs11786843 chr8:58133629 T/C cg24829409 chr8:58192753 C8orf71 -0.47 -9.01 -0.34 2.32e-18 Developmental language disorder (linguistic errors); BRCA cis rs13256369 0.851 rs13271698 chr8:8567539 C/A cg00074818 chr8:8560427 CLDN23 0.39 8.53 0.32 1.08e-16 Obesity-related traits; BRCA cis rs6484504 0.600 rs2761593 chr11:31326752 G/T cg26647111 chr11:31128758 NA 0.42 9.28 0.34 2.68e-19 Red blood cell count; BRCA cis rs9486719 0.948 rs2472906 chr6:96875318 G/T cg06623918 chr6:96969491 KIAA0776 0.73 12.95 0.46 3.16e-34 Migraine;Coronary artery disease; BRCA cis rs6740322 1.000 rs11693666 chr2:43562479 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 0.64 11.87 0.42 1.6800000000000001e-29 Coronary artery disease; BRCA cis rs763121 0.853 rs5750669 chr22:39080638 T/A cg06022373 chr22:39101656 GTPBP1 0.74 17.59 0.57 9.13e-57 Menopause (age at onset); BRCA cis rs877529 0.932 rs139403 chr22:39547021 G/A cg12193277 chr22:39547181 CBX7 0.48 13.12 0.46 5.53e-35 Multiple myeloma; BRCA cis rs7647973 0.925 rs6446257 chr3:49253492 A/G cg06212747 chr3:49208901 KLHDC8B -0.46 -8.18 -0.31 1.49e-15 Menarche (age at onset); BRCA trans rs3942852 0.688 rs10742834 chr11:48169717 G/A cg15704280 chr7:45808275 SEPT13 -0.54 -10.37 -0.38 2.22e-23 Acute lymphoblastic leukemia (childhood); BRCA cis rs72781680 0.848 rs56021814 chr2:24073437 T/A cg20701182 chr2:24300061 SF3B14 0.58 8.98 0.33 2.93e-18 Lymphocyte counts; BRCA cis rs2836950 0.545 rs2836956 chr21:40623018 C/G cg06238570 chr21:40685208 BRWD1 0.41 8.35 0.31 4.16e-16 Menarche (age at onset); BRCA cis rs2836974 0.932 rs8129416 chr21:40617145 C/T cg11644478 chr21:40555479 PSMG1 0.84 19.05 0.6 2.07e-64 Cognitive function; BRCA cis rs7809950 1.000 rs7778270 chr7:107224667 A/G cg23024343 chr7:107201750 COG5 0.41 9.06 0.34 1.57e-18 Coronary artery disease; BRCA cis rs870825 1.000 rs72689245 chr4:185579788 G/A cg04058563 chr4:185651563 MLF1IP 0.85 13.73 0.48 8.52e-38 Blood protein levels; BRCA cis rs7824557 0.583 rs2736306 chr8:11239762 A/T cg21775007 chr8:11205619 TDH 0.62 12.61 0.45 1.01e-32 Retinal vascular caliber; BRCA trans rs61931739 0.500 rs11053248 chr12:34518011 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs4819052 0.851 rs2877018 chr21:46658306 G/A cg06618935 chr21:46677482 NA -0.37 -7.94 -0.3 9e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9875589 0.957 rs60060718 chr3:13950333 G/A cg19554555 chr3:13937349 NA 0.43 8.95 0.33 3.88e-18 Ovarian reserve; BRCA cis rs10504229 0.683 rs55986917 chr8:58137210 C/T cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs711245 0.670 rs7560321 chr2:36822318 C/G cg01206211 chr2:36825736 FEZ2 -0.49 -12.81 -0.45 1.33e-33 Height; BRCA trans rs61931739 0.500 rs34080094 chr12:34547952 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.64 0.36 1.29e-20 Morning vs. evening chronotype; BRCA cis rs4689388 0.929 rs1046320 chr4:6304344 C/T cg25554036 chr4:6271136 WFS1 0.36 8.73 0.33 2.28e-17 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.39 -9.08 -0.34 1.3e-18 Longevity;Endometriosis; BRCA cis rs9443645 0.803 rs1547731 chr6:79776104 A/G cg18132916 chr6:79620363 NA -0.49 -11.12 -0.4 2.19e-26 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs11927068 chr3:134266321 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.9 0.62 6.05e-69 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10044254 0.563 rs12152734 chr5:15694406 A/G cg07238450 chr5:15720153 FBXL7 -0.39 -8.18 -0.31 1.57e-15 Asthma (corticosteroid response); BRCA cis rs7267979 1.000 rs422424 chr20:25445446 G/C cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7772486 0.603 rs2223411 chr6:146028767 T/C cg05347473 chr6:146136440 FBXO30 -0.61 -11.92 -0.43 1.06e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs2318143 chr8:58114660 C/T cg08219700 chr8:58056026 NA 0.44 7.91 0.3 1.12e-14 Developmental language disorder (linguistic errors); BRCA cis rs6461049 0.638 rs1859993 chr7:2183702 A/G cg14004847 chr7:1930337 MAD1L1 -0.38 -8.09 -0.3 3.03e-15 Schizophrenia; BRCA trans rs4332037 0.615 rs62435127 chr7:1884937 A/G cg25206134 chr2:45395956 NA 0.52 8.76 0.33 1.7e-17 Bipolar disorder; BRCA cis rs4319547 0.614 rs10846764 chr12:122874297 T/C cg23029597 chr12:123009494 RSRC2 0.63 12.15 0.43 1.0500000000000001e-30 Body mass index; BRCA cis rs6860806 0.661 rs4705927 chr5:131578608 C/G cg18301423 chr5:131593218 PDLIM4 0.32 8.2 0.31 1.28e-15 Breast cancer; BRCA cis rs12760731 0.668 rs73037529 chr1:178410203 A/T cg00404053 chr1:178313656 RASAL2 0.61 7.92 0.3 1.09e-14 Obesity-related traits; BRCA cis rs7618501 0.633 rs2526748 chr3:50080439 A/G cg24308560 chr3:49941425 MST1R 0.39 8.27 0.31 7.64e-16 Intelligence (multi-trait analysis); BRCA cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.74 0.36 5.54e-21 Menopause (age at onset); BRCA cis rs4478858 0.684 rs2062951 chr1:31762981 T/C cg00250761 chr1:31883323 NA -0.32 -8.33 -0.31 4.93e-16 Alcohol dependence; BRCA cis rs7044106 0.791 rs7043969 chr9:123493989 A/C cg09586646 chr9:123605570 PSMD5;LOC253039 0.7 15.16 0.51 1.39e-44 Hip circumference adjusted for BMI; BRCA cis rs9311474 0.508 rs7625743 chr3:52606366 C/G cg11041457 chr3:52719354 GNL3;PBRM1 0.38 13.18 0.46 2.94e-35 Electroencephalogram traits; BRCA trans rs1005277 0.579 rs2474580 chr10:38398713 G/A cg23533926 chr12:111358616 MYL2 -0.41 -8.53 -0.32 1.05e-16 Extrinsic epigenetic age acceleration; BRCA cis rs12701220 0.500 rs6463224 chr7:1140418 C/A cg02733842 chr7:1102375 C7orf50 -0.52 -9.71 -0.36 6.69e-21 Bronchopulmonary dysplasia; BRCA cis rs11249608 0.548 rs2047354 chr5:178455247 T/C cg21905437 chr5:178450457 ZNF879 0.52 10.79 0.39 4.69e-25 Pubertal anthropometrics; BRCA cis rs1008375 1.000 rs3815413 chr4:17654648 T/C cg04450456 chr4:17643702 FAM184B 0.39 11.54 0.42 4.04e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs514406 0.798 rs4351588 chr1:53263826 A/T cg24675658 chr1:53192096 ZYG11B 0.72 17.19 0.56 1.06e-54 Monocyte count; BRCA cis rs1580019 0.568 rs2122633 chr7:32523870 G/T cg14728415 chr7:32535168 LSM5;AVL9 0.4 8.62 0.32 5.27e-17 Cognitive ability; BRCA cis rs6910061 0.830 rs10946959 chr6:11096401 G/A cg27233058 chr6:11094804 LOC221710 0.5 8.42 0.32 2.44e-16 Diabetic kidney disease; BRCA cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg20701182 chr2:24300061 SF3B14 0.7 13.39 0.47 3.24e-36 Lymphocyte counts; BRCA cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg00383909 chr3:49044727 WDR6 0.63 11.36 0.41 2.33e-27 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2153535 0.580 rs6597334 chr6:8504779 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.57 0.39 3.62e-24 Motion sickness; BRCA cis rs9309711 0.961 rs11678655 chr2:3476234 T/G cg10845886 chr2:3471009 TTC15 -0.76 -16.3 -0.54 3.21e-50 Neurofibrillary tangles; BRCA cis rs9443645 0.527 rs2063123 chr6:79658535 T/C cg18132916 chr6:79620363 NA -0.39 -8.02 -0.3 5e-15 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.685 rs4556621 chr12:38187236 C/A cg26384229 chr12:38710491 ALG10B 0.76 16.93 0.56 2.12e-53 Bladder cancer; BRCA cis rs2842992 0.915 rs2842980 chr6:160100116 A/T cg16489826 chr6:160211363 TCP1;MRPL18 0.58 11.7 0.42 8.76e-29 Age-related macular degeneration (geographic atrophy); BRCA cis rs13256369 1.000 rs9329165 chr8:8576642 C/T cg18904891 chr8:8559673 CLDN23 -0.57 -11.28 -0.41 4.94e-27 Obesity-related traits; BRCA cis rs9837602 0.745 rs792834 chr3:99476121 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -10.6 -0.39 2.62e-24 Breast cancer; BRCA cis rs6831352 0.918 rs35784540 chr4:100061692 T/A cg13256891 chr4:100009986 ADH5 -0.52 -9.74 -0.36 5.46e-21 Alcohol dependence; BRCA cis rs6430585 0.941 rs12469551 chr2:136510012 T/G cg07169764 chr2:136633963 MCM6 -0.88 -17.61 -0.57 7.22e-57 Corneal structure; BRCA cis rs7666738 0.830 rs13108705 chr4:99044438 T/C cg05340658 chr4:99064831 C4orf37 0.7 17.61 0.57 7.25e-57 Colonoscopy-negative controls vs population controls; BRCA cis rs977987 0.778 rs62059846 chr16:75430809 T/A cg03315344 chr16:75512273 CHST6 0.52 12.24 0.44 4.23e-31 Dupuytren's disease; BRCA cis rs868036 1.000 rs4325504 chr15:68055570 A/G cg05925327 chr15:68127851 NA 0.34 8.54 0.32 9.66e-17 Restless legs syndrome; BRCA cis rs16921914 0.565 rs286650 chr11:31230207 T/C cg14844989 chr11:31128820 NA -0.45 -9.75 -0.36 4.79e-21 Bone mineral density (spine); BRCA cis rs7592578 0.882 rs7569128 chr2:191446691 C/A cg11845111 chr2:191398756 TMEM194B 0.78 14.55 0.5 1.3e-41 Diastolic blood pressure; BRCA cis rs7903847 0.642 rs7078004 chr10:99140511 A/G cg20016023 chr10:99160130 RRP12 -0.27 -8.59 -0.32 6.78e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs28830936 0.510 rs7175346 chr15:42100674 G/A cg17847044 chr15:42102381 MAPKBP1 -0.52 -19.98 -0.62 2.43e-69 Diastolic blood pressure; BRCA cis rs6088590 1.000 rs12626122 chr20:33425800 A/G cg08999081 chr20:33150536 PIGU 0.37 8.92 0.33 4.74e-18 Coronary artery disease; BRCA cis rs10479542 0.892 rs7736163 chr5:178980316 G/C cg19626725 chr5:178986131 RUFY1 0.32 9.6 0.35 1.83e-20 Lung cancer; BRCA cis rs7666738 0.830 rs1426662 chr4:98990319 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.73 0.39 8.52e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.963 rs10789484 chr1:46406978 G/C cg03146154 chr1:46216737 IPP 0.46 10.22 0.37 7.99e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg07636037 chr3:49044803 WDR6 -0.39 -8.13 -0.31 2.17e-15 Resting heart rate; BRCA cis rs4771122 0.697 rs1475220 chr13:28037448 G/C cg22138327 chr13:27999177 GTF3A -0.44 -8.57 -0.32 7.91e-17 Body mass index; BRCA cis rs4819052 0.851 rs9974891 chr21:46680767 T/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.43 8.3 0.31 6.18e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs769267 0.930 rs2099334 chr19:19578450 A/G cg01262667 chr19:19385393 TM6SF2 0.41 10.74 0.39 7.82e-25 Tonsillectomy; BRCA cis rs96067 0.711 rs272833 chr1:36622870 C/G cg24686825 chr1:36642396 MAP7D1 -0.56 -11.28 -0.41 4.88e-27 Corneal structure; BRCA cis rs2762353 0.935 rs1892249 chr6:25768992 A/G cg12310025 chr6:25882481 NA 0.51 12.0 0.43 4.71e-30 Blood metabolite levels; BRCA cis rs17601876 0.807 rs4545755 chr15:51549044 G/A cg19946085 chr15:51559439 CYP19A1 -0.36 -9.42 -0.35 7.82e-20 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9287719 0.753 rs2018512 chr2:10759279 T/G cg00105475 chr2:10696890 NA 0.42 9.61 0.36 1.65e-20 Prostate cancer; BRCA cis rs4285028 0.747 rs11916169 chr3:121403211 A/G cg01951420 chr3:121553821 IQCB1;EAF2 -0.83 -16.05 -0.54 5.97e-49 Multiple sclerosis; BRCA cis rs4927850 1.000 rs10881564 chr3:195750326 C/T cg12923728 chr3:195709715 SDHAP1 -0.59 -12.6 -0.45 1.14e-32 Pancreatic cancer; BRCA trans rs1005277 0.579 rs2505240 chr10:38442419 G/T cg23533926 chr12:111358616 MYL2 -0.41 -8.61 -0.32 5.77e-17 Extrinsic epigenetic age acceleration; BRCA cis rs9314323 0.524 rs7816609 chr8:26202482 A/C cg11498726 chr8:26250323 BNIP3L -0.37 -8.43 -0.32 2.29e-16 Red cell distribution width; BRCA cis rs244731 0.959 rs9313752 chr5:176645435 G/T cg16006841 chr5:176797999 RGS14 -0.7 -10.97 -0.4 9.1e-26 Urate levels in lean individuals; BRCA cis rs2075371 0.611 rs11762920 chr7:134018514 C/T cg20476274 chr7:133979776 SLC35B4 0.51 11.82 0.42 2.82e-29 Mean platelet volume; BRCA cis rs847577 0.677 rs951988 chr7:97762474 C/G cg24562669 chr7:97807699 LMTK2 -0.49 -13.2 -0.46 2.47e-35 Breast cancer; BRCA cis rs8072100 0.666 rs9913014 chr17:45460189 C/T cg08085267 chr17:45401833 C17orf57 -0.6 -12.11 -0.43 1.48e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6460942 0.749 rs62448592 chr7:12435985 A/T cg06484146 chr7:12443880 VWDE -0.74 -10.57 -0.39 3.58e-24 Coronary artery disease; BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg26119090 chr2:26468346 HADHA;HADHB -0.77 -13.59 -0.47 3.87e-37 Gut microbiome composition (summer); BRCA cis rs9487051 0.714 rs13209277 chr6:109624963 T/A cg01475377 chr6:109611718 NA -0.53 -14.11 -0.49 1.54e-39 Reticulocyte fraction of red cells; BRCA cis rs3925075 0.525 rs2011491 chr16:31280255 G/A cg02846316 chr16:31340340 ITGAM 0.43 8.78 0.33 1.55e-17 IgA nephropathy; BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.75 11.05 0.4 4.26e-26 Platelet count; BRCA cis rs1832871 0.599 rs1539312 chr6:158743188 G/A cg07215822 chr6:158701037 NA 0.47 9.55 0.35 2.8e-20 Height; BRCA trans rs7824557 0.767 rs28507159 chr8:11166076 C/T cg15556689 chr8:8085844 FLJ10661 0.37 8.73 0.33 2.23e-17 Retinal vascular caliber; BRCA cis rs55788414 0.932 rs9936302 chr16:81190790 C/T cg06400318 chr16:81190750 PKD1L2 -1.01 -16.84 -0.55 6.04e-53 Left ventricular obstructive tract defect (maternal effect); BRCA cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg02018176 chr4:1364513 KIAA1530 -0.38 -8.18 -0.31 1.52e-15 Longevity; BRCA cis rs4363385 0.818 rs558363 chr1:153010431 C/T cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs826838 0.967 rs11168985 chr12:39045983 A/C cg13010199 chr12:38710504 ALG10B -0.55 -12.38 -0.44 1.09e-31 Heart rate; BRCA cis rs4819052 0.851 rs35064782 chr21:46674360 G/A cg06618935 chr21:46677482 NA -0.37 -8.11 -0.31 2.59e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs36051895 0.623 rs1555476 chr9:5233054 T/C cg02405213 chr9:5042618 JAK2 -0.47 -8.12 -0.31 2.41e-15 Pediatric autoimmune diseases; BRCA cis rs7666738 0.830 rs6819047 chr4:98866902 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs7672720 chr4:98938760 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.3 0.38 4.03e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10206020 0.885 rs13411553 chr2:1574018 A/G cg12573674 chr2:1569213 NA -0.57 -12.88 -0.45 6.39e-34 IgG glycosylation; BRCA cis rs6738485 0.861 rs13014335 chr2:106802805 A/G cg16099169 chr2:106886729 NA -0.4 -8.19 -0.31 1.45e-15 Pursuit maintenance gain;Pursuit maintenance gain in psychotic disorders; BRCA cis rs965469 0.779 rs6051836 chr20:3386482 C/T cg25506879 chr20:3388711 C20orf194 -0.43 -8.41 -0.32 2.58e-16 IFN-related cytopenia; BRCA cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg22467129 chr15:76604101 ETFA -0.49 -10.66 -0.39 1.51e-24 Blood metabolite levels; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg23285459 chr7:2802560 GNA12 -0.32 -8.57 -0.32 7.76e-17 Height; BRCA cis rs6484504 0.576 rs2150213 chr11:31244634 A/G cg14844989 chr11:31128820 NA -0.45 -9.59 -0.35 1.8899999999999998e-20 Red blood cell count; BRCA cis rs3741404 0.574 rs638227 chr11:63871549 T/C cg18225595 chr11:63971243 STIP1 0.4 9.93 0.37 1.05e-21 Platelet count; BRCA cis rs2455799 0.573 rs2455812 chr3:15734096 C/G cg16303742 chr3:15540471 COLQ -0.37 -9.05 -0.34 1.65e-18 Mean platelet volume; BRCA cis rs4820539 0.641 rs5759602 chr22:23489362 C/T cg14186256 chr22:23484241 RTDR1 -0.71 -18.03 -0.58 4.53e-59 Bone mineral density; BRCA trans rs75804782 0.521 rs72982596 chr2:239454919 G/C cg01134436 chr17:81009848 B3GNTL1 0.63 8.36 0.31 3.83e-16 Morning vs. evening chronotype;Chronotype; BRCA cis rs11123170 0.640 rs931472 chr2:113969948 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 -0.56 -10.09 -0.37 2.67e-22 Renal function-related traits (BUN); BRCA cis rs7552404 0.727 rs4949677 chr1:76266662 T/A cg03433033 chr1:76189801 ACADM 0.69 13.77 0.48 5.96e-38 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7666738 0.830 rs10001479 chr4:98918764 A/G cg05340658 chr4:99064831 C4orf37 -0.61 -13.9 -0.48 1.39e-38 Colonoscopy-negative controls vs population controls; BRCA cis rs9796 0.553 rs7171437 chr15:41315168 G/A cg18705301 chr15:41695430 NDUFAF1 -0.4 -8.21 -0.31 1.25e-15 Menopause (age at onset); BRCA cis rs12701220 0.894 rs34712249 chr7:1036634 C/T cg00990874 chr7:1149470 C7orf50 -0.52 -9.4 -0.35 9.72e-20 Bronchopulmonary dysplasia; BRCA cis rs11030122 0.702 rs66503725 chr11:3980998 G/A cg18678763 chr11:4115507 RRM1 -0.35 -7.89 -0.3 1.27e-14 Mean platelet volume;Platelet distribution width; BRCA cis rs1941023 0.584 rs950803 chr11:60152563 A/T cg08716584 chr11:60157161 MS4A7 0.41 9.75 0.36 5.08e-21 Congenital heart disease (maternal effect); BRCA cis rs2836974 0.897 rs2836925 chr21:40532353 T/C cg11644478 chr21:40555479 PSMG1 0.82 18.54 0.59 1.05e-61 Cognitive function; BRCA cis rs2294693 0.945 rs9381023 chr6:40983281 C/T cg14418226 chr6:40996092 UNC5CL -0.44 -7.89 -0.3 1.32e-14 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs10504229 0.683 rs7464038 chr8:58111908 T/C cg22535103 chr8:58192502 C8orf71 -0.48 -9.34 -0.35 1.59e-19 Developmental language disorder (linguistic errors); BRCA trans rs9329221 0.683 rs555200 chr8:9888729 A/G cg21775007 chr8:11205619 TDH -0.39 -8.07 -0.3 3.57e-15 Neuroticism; BRCA cis rs7666738 0.830 rs4619898 chr4:98959646 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1577917 0.545 rs1335443 chr6:86478737 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.36 -9.72 -0.36 6.31e-21 Response to antipsychotic treatment; BRCA cis rs6121246 0.909 rs6060870 chr20:30303299 C/T cg13852791 chr20:30311386 BCL2L1 0.86 16.75 0.55 1.82e-52 Mean corpuscular hemoglobin; BRCA cis rs3858526 0.920 rs11039698 chr11:5950907 C/T cg02574844 chr11:5959923 NA -0.43 -8.42 -0.32 2.55e-16 DNA methylation (variation); BRCA cis rs922182 0.633 rs16947621 chr15:64271660 C/G cg24729988 chr15:64271149 DAPK2 0.64 16.79 0.55 1.16e-52 Blood protein levels; BRCA trans rs7939886 0.920 rs7112964 chr11:55866408 T/C cg15704280 chr7:45808275 SEPT13 0.6 7.88 0.3 1.38e-14 Myopia (pathological); BRCA cis rs9649213 0.574 rs7791321 chr7:97944125 G/C cg24562669 chr7:97807699 LMTK2 0.46 12.47 0.44 4.14e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs79146658 0.736 rs4894060 chr2:179751817 T/A cg17765952 chr2:179737173 CCDC141 -0.45 -7.84 -0.3 1.9e-14 Diastolic blood pressure; BRCA cis rs490234 0.756 rs1398142 chr9:128226712 C/A cg14078157 chr9:128172775 NA -0.36 -8.43 -0.32 2.25e-16 Mean arterial pressure; BRCA cis rs36051895 0.564 rs7874624 chr9:5179865 A/G cg02405213 chr9:5042618 JAK2 -0.48 -9.36 -0.35 1.31e-19 Pediatric autoimmune diseases; BRCA cis rs7666738 0.791 rs1896156 chr4:99020882 C/G cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1008375 0.966 rs2010053 chr4:17583806 A/C cg15017067 chr4:17643749 FAM184B 0.35 10.83 0.39 3.2e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs61931739 0.500 rs11053189 chr12:34433455 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.57 0.35 2.32e-20 Morning vs. evening chronotype; BRCA cis rs11585357 0.895 rs2977305 chr1:17613737 A/T cg19159961 chr1:17633534 PADI4 -0.5 -8.65 -0.32 4.1e-17 Hair shape; BRCA cis rs778371 0.915 rs938569 chr2:233759695 C/G cg08000102 chr2:233561755 GIGYF2 0.75 15.26 0.52 4.73e-45 Schizophrenia; BRCA cis rs4660306 1.000 rs7534467 chr1:45988691 G/A cg24296786 chr1:45957014 TESK2 0.43 8.66 0.32 3.96e-17 Homocysteine levels; BRCA cis rs514406 0.861 rs12141260 chr1:53300127 C/T cg25767906 chr1:53392781 SCP2 -0.36 -8.13 -0.31 2.16e-15 Monocyte count; BRCA cis rs10504229 1.000 rs17216648 chr8:58169429 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.59 -0.47 3.72e-37 Developmental language disorder (linguistic errors); BRCA cis rs28595532 0.920 rs17258830 chr4:119725543 A/T cg14228332 chr4:119757509 SEC24D -0.65 -7.98 -0.3 6.55e-15 Cannabis dependence symptom count; BRCA cis rs9389248 0.708 rs7750574 chr6:135350932 G/C cg22676075 chr6:135203613 NA 0.44 8.71 0.33 2.6e-17 High light scatter reticulocyte percentage of red cells; BRCA cis rs7811142 1.000 rs11771419 chr7:99988403 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.09 20.23 0.62 1.01e-70 Platelet count; BRCA cis rs6088580 0.505 rs6058106 chr20:33278255 T/C cg08999081 chr20:33150536 PIGU -0.31 -7.85 -0.3 1.79e-14 Glomerular filtration rate (creatinine); BRCA cis rs3858526 0.959 rs10838797 chr11:5920977 A/G cg02574844 chr11:5959923 NA -0.43 -8.44 -0.32 2.08e-16 DNA methylation (variation); BRCA cis rs7615952 0.515 rs7637246 chr3:125678706 A/G cg05084668 chr3:125655381 ALG1L -0.63 -11.89 -0.43 1.42e-29 Blood pressure (smoking interaction); BRCA cis rs17401966 0.540 rs7546368 chr1:10418826 G/A cg03954927 chr1:10346856 KIF1B 0.35 10.72 0.39 9.15e-25 Hepatocellular carcinoma; BRCA cis rs12586317 0.547 rs114371385 chr14:35503724 G/A cg16230307 chr14:35515116 FAM177A1 0.72 14.94 0.51 1.73e-43 Psoriasis; BRCA cis rs1801251 0.656 rs10211596 chr2:233699415 C/T cg25237894 chr2:233734115 C2orf82 -0.3 -8.91 -0.33 5.32e-18 Coronary artery disease; BRCA cis rs870825 0.616 rs4623060 chr4:185642943 A/G cg04058563 chr4:185651563 MLF1IP 0.76 16.78 0.55 1.26e-52 Blood protein levels; BRCA cis rs10499694 0.933 rs12538938 chr7:50592313 A/G cg18232548 chr7:50535776 DDC -0.39 -9.39 -0.35 1.04e-19 Body mass index; BRCA cis rs1003719 0.713 rs2835594 chr21:38466064 G/A cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA trans rs61931739 0.517 rs11612493 chr12:34114272 A/C cg13010199 chr12:38710504 ALG10B 0.45 8.99 0.34 2.73e-18 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs9832785 chr3:134213070 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.89e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs175714 0.845 rs175706 chr14:75976200 G/A cg01624173 chr14:75981868 NA 0.34 9.31 0.35 2e-19 Lymphocyte counts; BRCA cis rs7246657 0.943 rs7255952 chr19:37988797 A/G cg23950597 chr19:37808831 NA -0.64 -11.72 -0.42 6.91e-29 Coronary artery calcification; BRCA cis rs60871478 0.636 rs4721600 chr7:871728 C/T cg05535760 chr7:792225 HEATR2 -0.72 -11.55 -0.42 3.73e-28 Cerebrospinal P-tau181p levels; BRCA cis rs250677 0.687 rs250671 chr5:148446523 T/C cg23229984 chr5:148520753 ABLIM3 0.36 8.74 0.33 2.06e-17 Breast cancer; BRCA cis rs13191362 1.000 rs35911566 chr6:162994154 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.53 8.89 0.33 6.37e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.639 rs55687236 chr8:58105856 C/T cg21724239 chr8:58056113 NA 0.65 10.15 0.37 1.52e-22 Developmental language disorder (linguistic errors); BRCA cis rs11231017 0.507 rs11231025 chr11:62073305 C/G cg23876832 chr11:62092739 NA 0.32 8.09 0.3 2.92e-15 HIV-1 viral setpoint; BRCA cis rs801193 1.000 rs6958520 chr7:66151453 T/C cg11764359 chr7:65958608 NA 0.67 15.05 0.51 4.64e-44 Aortic root size; BRCA cis rs12477438 0.501 rs13033012 chr2:99795149 T/C cg08885076 chr2:99613938 TSGA10 0.41 9.63 0.36 1.4e-20 Chronic sinus infection; BRCA cis rs9914988 0.943 rs9891925 chr17:27104540 A/T cg20469991 chr17:27169893 C17orf63 -0.45 -8.76 -0.33 1.75e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs10044254 0.614 rs13358928 chr5:15737539 G/T cg07238450 chr5:15720153 FBXL7 -0.38 -8.02 -0.3 5.21e-15 Asthma (corticosteroid response); BRCA cis rs17401966 0.838 rs946502 chr1:10309279 G/C cg03954927 chr1:10346856 KIF1B 0.44 13.78 0.48 5.01e-38 Hepatocellular carcinoma; BRCA cis rs1580019 0.885 rs1610141 chr7:32498435 C/T cg07520158 chr7:32535189 LSM5;AVL9 0.42 8.86 0.33 7.99e-18 Cognitive ability; BRCA cis rs4713118 0.824 rs9366702 chr6:27734470 T/C cg20933634 chr6:27740509 NA 0.48 9.49 0.35 4.58e-20 Parkinson's disease; BRCA cis rs16958440 0.867 rs74411203 chr18:44677466 G/A cg17192377 chr18:44677553 HDHD2 0.99 13.58 0.47 4.48e-37 Sitting height ratio; BRCA cis rs6964587 1.000 rs12704635 chr7:91737324 T/G cg01689657 chr7:91764605 CYP51A1 0.22 8.18 0.31 1.52e-15 Breast cancer; BRCA cis rs11758351 0.734 rs56220351 chr6:26206884 A/G cg01420254 chr6:26195488 NA 0.54 8.43 0.32 2.24e-16 Gout;Renal underexcretion gout; BRCA cis rs910316 0.737 rs175071 chr14:75498177 A/G cg08847533 chr14:75593920 NEK9 -0.85 -21.3 -0.64 1.76e-76 Height; BRCA trans rs4596713 0.507 rs10115283 chr9:71801162 T/G cg16512924 chr15:28394682 HERC2 0.45 10.64 0.39 1.82e-24 Headache; BRCA cis rs2742234 0.590 rs2075912 chr10:43622217 T/C cg15436174 chr10:43711423 RASGEF1A -0.53 -10.75 -0.39 6.99e-25 Hirschsprung disease; BRCA cis rs938554 0.513 rs11943372 chr4:9999346 T/A cg00071950 chr4:10020882 SLC2A9 0.39 8.3 0.31 6.16e-16 Blood metabolite levels; BRCA cis rs11123170 0.529 rs112692022 chr2:113970182 C/T cg12889195 chr2:113992843 PAX8;LOC440839;LOC654433 0.55 9.29 0.34 2.43e-19 Renal function-related traits (BUN); BRCA cis rs2153535 0.580 rs2143356 chr6:8517675 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.6 0.39 2.83e-24 Motion sickness; BRCA trans rs11039798 1.000 rs7125559 chr11:48984207 C/G cg15704280 chr7:45808275 SEPT13 0.6 8.84 0.33 8.93e-18 Axial length; BRCA trans rs7819412 0.595 rs10106914 chr8:10987651 T/G cg08975724 chr8:8085496 FLJ10661 -0.39 -8.08 -0.3 3.35e-15 Triglycerides; BRCA cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg04455712 chr21:45112962 RRP1B 0.42 10.86 0.39 2.47e-25 Mean corpuscular volume; BRCA cis rs9381040 0.655 rs4140578 chr6:41041829 A/G cg03644281 chr6:41068752 NFYA;LOC221442 -0.42 -8.98 -0.33 3.08e-18 Alzheimer's disease (late onset); BRCA cis rs524281 0.861 rs7931544 chr11:65917034 C/T cg16950941 chr11:66035639 RAB1B -0.37 -7.86 -0.3 1.6e-14 Electroencephalogram traits; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg10150615 chr22:24372951 LOC391322 -0.43 -9.76 -0.36 4.55e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs11676348 0.776 rs11690316 chr2:219017462 A/G cg00012203 chr2:219082015 ARPC2 -0.46 -8.9 -0.33 5.73e-18 Ulcerative colitis; BRCA cis rs796364 0.806 rs11694236 chr2:200916230 T/C cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs13046373 0.535 rs1395778 chr21:31985502 G/C cg16812893 chr21:31813075 KRTAP15-1 0.37 9.09 0.34 1.26e-18 HDL cholesterol; BRCA cis rs13064411 0.696 rs7631082 chr3:113208913 C/G cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2882667 0.690 rs13158360 chr5:138258177 G/A cg04439458 chr5:138467593 SIL1 -0.31 -7.89 -0.3 1.29e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2836974 0.549 rs34160989 chr21:40554118 C/G cg17971929 chr21:40555470 PSMG1 0.58 9.01 0.34 2.36e-18 Cognitive function; BRCA trans rs2727020 0.521 rs7930855 chr11:49521660 C/T cg03929089 chr4:120376271 NA 0.64 12.64 0.45 7.27e-33 Coronary artery disease; BRCA cis rs7666738 0.830 rs6819177 chr4:99040907 T/C cg03676636 chr4:99064102 C4orf37 0.21 8.02 0.3 5.17e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg24531977 chr5:56204891 C5orf35 -0.88 -18.13 -0.58 1.46e-59 Initial pursuit acceleration; BRCA cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg24296786 chr1:45957014 TESK2 0.65 16.08 0.54 4.27e-49 High light scatter reticulocyte count; BRCA cis rs6951245 0.572 rs112072378 chr7:1039400 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -11.19 -0.4 1.18e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2762353 0.574 rs16890999 chr6:25755583 A/G cg03517284 chr6:25882590 NA 0.68 15.76 0.53 1.56e-47 Blood metabolite levels; BRCA cis rs6840360 0.550 rs6535806 chr4:152483906 G/A cg22705602 chr4:152727874 NA -0.31 -8.06 -0.3 3.68e-15 Intelligence (multi-trait analysis); BRCA cis rs4819052 0.851 rs13049337 chr21:46663460 T/G cg06618935 chr21:46677482 NA -0.36 -7.98 -0.3 6.64e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg23978390 chr7:1156363 C7orf50 0.5 11.58 0.42 2.69e-28 Longevity;Endometriosis; BRCA cis rs10782582 0.593 rs11578480 chr1:76208989 T/G cg03433033 chr1:76189801 ACADM -0.49 -10.37 -0.38 2.17e-23 Daytime sleep phenotypes; BRCA cis rs9287719 0.649 rs10929683 chr2:10732208 C/T cg00105475 chr2:10696890 NA -0.42 -9.24 -0.34 3.6e-19 Prostate cancer; BRCA cis rs2180341 0.855 rs9385422 chr6:127716457 C/T cg27446573 chr6:127587934 RNF146 0.7 15.78 0.53 1.27e-47 Breast cancer; BRCA cis rs1997103 0.906 rs6593231 chr7:55402914 T/A cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs2645694 0.626 rs2645684 chr4:77819892 A/C cg06046430 chr4:77819534 ANKRD56 0.61 13.51 0.47 9.58e-37 Emphysema distribution in smoking; BRCA cis rs4948102 0.731 rs10229446 chr7:56064262 A/G cg09872392 chr7:56161020 PHKG1 0.38 8.67 0.32 3.69e-17 Plasma homocysteine levels (post-methionine load test); BRCA trans rs10506458 0.915 rs12423078 chr12:63397529 C/T cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.25 -20.33 -0.63 3.09e-71 Hemostatic factors and hematological phenotypes; BRCA cis rs1008375 0.966 rs11947836 chr4:17697187 A/G cg15017067 chr4:17643749 FAM184B -0.27 -8.24 -0.31 1e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.590 rs4665319 chr2:26424583 A/C cg04944784 chr2:26401820 FAM59B -0.88 -15.84 -0.53 6.35e-48 Gut microbiome composition (summer); BRCA cis rs17376456 1.000 rs58734583 chr5:93532155 C/T cg21475434 chr5:93447410 FAM172A 0.69 9.09 0.34 1.27e-18 Diabetic retinopathy; BRCA cis rs9733 0.596 rs6692960 chr1:150695965 G/A cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs2836974 0.613 rs2245455 chr21:40548087 A/T cg17971929 chr21:40555470 PSMG1 -0.56 -13.46 -0.47 1.52e-36 Cognitive function; BRCA cis rs8103278 1.000 rs725660 chr19:46262286 C/A cg14061069 chr19:46274453 DMPK -0.5 -12.44 -0.44 5.54e-32 Coronary artery disease; BRCA cis rs12477438 0.520 rs13035311 chr2:99717322 C/G cg08885076 chr2:99613938 TSGA10 0.46 10.77 0.39 5.97e-25 Chronic sinus infection; BRCA cis rs2204008 0.626 rs11520260 chr12:38330092 C/T cg26384229 chr12:38710491 ALG10B 0.75 17.26 0.56 4.56e-55 Bladder cancer; BRCA trans rs7618501 0.633 rs6771546 chr3:49968572 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.31 8.46 0.32 1.8e-16 Intelligence (multi-trait analysis); BRCA cis rs9649465 0.902 rs10253850 chr7:123273095 T/C cg04330084 chr7:123175371 IQUB -0.32 -8.77 -0.33 1.56e-17 Migraine; BRCA cis rs12188164 0.561 rs2251843 chr5:457955 C/T cg16584290 chr5:462447 EXOC3 -0.51 -14.31 -0.49 1.69e-40 Cystic fibrosis severity; BRCA trans rs9329221 0.655 rs656319 chr8:9814411 A/G cg06636001 chr8:8085503 FLJ10661 -0.47 -10.1 -0.37 2.28e-22 Neuroticism; BRCA cis rs9487051 0.837 rs932223 chr6:109586656 A/G cg01475377 chr6:109611718 NA -0.55 -15.03 -0.51 6.34e-44 Reticulocyte fraction of red cells; BRCA cis rs6964587 1.000 rs36021614 chr7:91717490 C/G cg01689657 chr7:91764605 CYP51A1 0.23 8.43 0.32 2.29e-16 Breast cancer; BRCA cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg24562669 chr7:97807699 LMTK2 0.47 12.44 0.44 5.97e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.895 rs6460278 chr7:65662736 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.84 -0.3 1.86e-14 Aortic root size; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg05793240 chr7:2802953 GNA12 -0.33 -8.05 -0.3 4.05e-15 Height; BRCA cis rs7618501 0.633 rs2856234 chr3:50139142 A/G cg24308560 chr3:49941425 MST1R 0.38 8.14 0.31 2.07e-15 Intelligence (multi-trait analysis); BRCA cis rs4363385 0.747 rs885096 chr1:152971313 T/C cg25856811 chr1:152973957 SPRR3 -0.34 -8.98 -0.33 3.11e-18 Inflammatory skin disease; BRCA cis rs12579753 0.869 rs12366921 chr12:82223024 G/A cg07988820 chr12:82153109 PPFIA2 -0.64 -10.09 -0.37 2.58e-22 Resting heart rate; BRCA cis rs270601 0.683 rs81598 chr5:131587960 C/G cg12564285 chr5:131593104 PDLIM4 0.37 9.51 0.35 3.72e-20 Acylcarnitine levels; BRCA cis rs9457247 0.663 rs2282860 chr6:167440244 T/C cg07741184 chr6:167504864 NA 0.27 8.1 0.31 2.78e-15 Crohn's disease; BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg26314531 chr2:26401878 FAM59B 0.93 14.02 0.49 3.95e-39 Gut microbiome composition (summer); BRCA cis rs6570726 0.846 rs411468 chr6:145832792 A/G cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs3096299 0.967 rs2911257 chr16:89484134 C/G cg08822215 chr16:89438651 ANKRD11 -0.38 -8.13 -0.31 2.15e-15 Multiple myeloma (IgH translocation); BRCA cis rs801193 0.569 rs2659907 chr7:66164032 G/A cg11764359 chr7:65958608 NA 0.74 16.67 0.55 4.38e-52 Aortic root size; BRCA cis rs17270561 0.666 rs9356988 chr6:25777481 G/A cg17691542 chr6:26056736 HIST1H1C 0.51 10.13 0.37 1.88e-22 Iron status biomarkers; BRCA cis rs10504229 0.545 rs56394419 chr8:58128982 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs1005277 0.579 rs1780146 chr10:38517874 C/A cg00409905 chr10:38381863 ZNF37A -0.48 -9.96 -0.37 7.79e-22 Extrinsic epigenetic age acceleration; BRCA cis rs4689388 0.890 rs4688989 chr4:6290594 T/C cg25554036 chr4:6271136 WFS1 0.43 10.13 0.37 1.82e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs11608355 0.515 rs35691047 chr12:109932585 C/T cg05360138 chr12:110035743 NA 0.74 13.68 0.48 1.56e-37 Neuroticism; BRCA cis rs12760731 0.668 rs72482621 chr1:178410442 C/T cg00404053 chr1:178313656 RASAL2 0.62 8.13 0.31 2.26e-15 Obesity-related traits; BRCA cis rs10256972 0.514 rs2140578 chr7:1214003 T/C cg18765753 chr7:1198926 ZFAND2A -0.49 -11.93 -0.43 9e-30 Longevity;Endometriosis; BRCA cis rs701145 0.585 rs896013 chr3:153863873 A/G cg12800244 chr3:153838788 SGEF 0.58 8.15 0.31 1.9e-15 Coronary artery disease; BRCA cis rs17345786 0.520 rs12638134 chr3:101334609 G/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.41 9.78 0.36 3.93e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4862307 0.836 rs13107384 chr4:185004073 C/T cg06737308 chr4:185021514 ENPP6 -0.37 -8.14 -0.31 2.09e-15 Serum dimethylarginine levels (asymmetric/symetric ratio); BRCA cis rs4819052 0.851 rs2838826 chr21:46655785 A/G cg11663144 chr21:46675770 NA -0.54 -12.85 -0.45 8.64e-34 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1707322 1.000 rs6676982 chr1:46275401 A/T cg03146154 chr1:46216737 IPP 0.46 10.03 0.37 4.21e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4665809 1.000 rs6709595 chr2:26259885 A/G cg25036284 chr2:26402008 FAM59B -0.63 -10.95 -0.4 1.12e-25 Gut microbiome composition (summer); BRCA cis rs4853012 0.941 rs4852329 chr2:74354544 A/G cg05890377 chr2:74357713 NA 0.59 12.05 0.43 2.7e-30 Gestational age at birth (maternal effect); BRCA cis rs7633857 0.512 rs13098529 chr3:160657053 A/G cg03342759 chr3:160939853 NMD3 -0.51 -10.83 -0.39 3.37e-25 Educational attainment (years of education); BRCA cis rs763121 0.853 rs11704021 chr22:39074716 G/A cg06022373 chr22:39101656 GTPBP1 0.73 17.6 0.57 7.85e-57 Menopause (age at onset); BRCA cis rs7267979 0.966 rs6083818 chr20:25346082 G/A cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.31 -0.35 2.04e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6594499 0.542 rs7722241 chr5:110460747 T/A cg04022379 chr5:110408740 TSLP 0.36 8.17 0.31 1.71e-15 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7666738 0.830 rs13113899 chr4:99050422 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.68 0.39 1.35e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs17023223 0.537 rs12081198 chr1:119686104 A/C cg05756136 chr1:119680316 WARS2 -0.41 -7.88 -0.3 1.41e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA trans rs3749237 1.000 rs11920900 chr3:49823024 G/C cg21659725 chr3:3221576 CRBN 0.49 11.06 0.4 3.9e-26 Resting heart rate; BRCA cis rs9811920 0.609 rs793462 chr3:99616461 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg21724239 chr8:58056113 NA -0.58 -9.19 -0.34 5.66e-19 Developmental language disorder (linguistic errors); BRCA cis rs57590327 0.508 rs7621968 chr3:81951460 A/G cg07356753 chr3:81810745 GBE1 -0.4 -9.47 -0.35 5.32e-20 Extraversion; BRCA cis rs10791323 0.569 rs10791328 chr11:133713730 A/G cg06766960 chr11:133703094 NA -0.64 -13.21 -0.46 2.05e-35 Childhood ear infection; BRCA cis rs6665290 0.901 rs61834001 chr1:227197411 C/T cg10327440 chr1:227177885 CDC42BPA -1.16 -48.97 -0.89 1.81e-218 Myeloid white cell count; BRCA trans rs7824557 0.767 rs4559208 chr8:11153925 C/G cg15556689 chr8:8085844 FLJ10661 0.37 9.09 0.34 1.19e-18 Retinal vascular caliber; BRCA cis rs3806843 0.832 rs2531360 chr5:140116664 G/A cg16179182 chr5:140090404 VTRNA1-1 0.41 9.53 0.35 3.28e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs250677 0.522 rs12520924 chr5:148349149 C/T cg12140854 chr5:148520817 ABLIM3 0.41 8.23 0.31 1.04e-15 Breast cancer; BRCA cis rs11098499 0.909 rs10014719 chr4:120320715 G/A cg09307838 chr4:120376055 NA 0.73 15.87 0.53 4.5e-48 Corneal astigmatism; BRCA cis rs798554 0.660 rs2644274 chr7:2854380 A/T cg04166393 chr7:2884313 GNA12 0.4 8.57 0.32 7.91e-17 Height; BRCA cis rs1443512 0.812 rs4759058 chr12:54339052 C/A cg17410650 chr12:54324560 NA -0.43 -10.73 -0.39 8.16e-25 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in non-smokers;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction);Waist-hip ratio;Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour); BRCA cis rs4665809 1.000 rs6749855 chr2:26255263 A/G cg26314531 chr2:26401878 FAM59B -0.66 -10.72 -0.39 8.78e-25 Gut microbiome composition (summer); BRCA cis rs826838 1.000 rs6582619 chr12:38729904 A/G cg26384229 chr12:38710491 ALG10B 0.85 23.28 0.68 2.68e-87 Heart rate; BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg25036284 chr2:26402008 FAM59B 0.94 15.84 0.53 6.66e-48 Gut microbiome composition (summer); BRCA cis rs737008 0.500 rs7189239 chr16:11402515 T/C cg00044050 chr16:11439710 C16orf75 0.48 11.63 0.42 1.65e-28 Obesity-related traits; BRCA cis rs17376456 0.877 rs17083460 chr5:93462354 A/G cg21475434 chr5:93447410 FAM172A 0.67 9.17 0.34 6.36e-19 Diabetic retinopathy; BRCA cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg04414720 chr1:150670196 GOLPH3L 0.35 7.87 0.3 1.55e-14 Tonsillectomy; BRCA cis rs2386661 0.547 rs4747358 chr10:5650193 A/G cg17085576 chr10:5658249 NA 0.36 8.81 0.33 1.19e-17 Breast cancer; BRCA cis rs10504229 0.639 rs72650811 chr8:58115661 G/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.22e-16 Developmental language disorder (linguistic errors); BRCA cis rs9291683 0.588 rs13121211 chr4:9999539 A/G cg00071950 chr4:10020882 SLC2A9 0.55 13.5 0.47 1.03e-36 Bone mineral density; BRCA cis rs35306767 0.761 rs12771539 chr10:1050653 A/G cg20503657 chr10:835505 NA 0.95 14.77 0.5 1.14e-42 Eosinophil percentage of granulocytes; BRCA cis rs4319547 0.695 rs10773167 chr12:122934001 C/T cg05707623 chr12:122985044 ZCCHC8 -0.53 -10.12 -0.37 1.92e-22 Body mass index; BRCA cis rs7264396 0.561 rs6058388 chr20:34571846 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.6 -12.65 -0.45 6.99e-33 Total cholesterol levels; BRCA cis rs6964587 0.967 rs10279943 chr7:91587477 G/C cg01689657 chr7:91764605 CYP51A1 0.22 8.17 0.31 1.69e-15 Breast cancer; BRCA cis rs2576037 0.583 rs9304336 chr18:44461687 T/C cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.91 -0.4 1.53e-25 Personality dimensions; BRCA cis rs9682041 0.877 rs10804841 chr3:170072031 T/A cg11886554 chr3:170076028 SKIL 0.53 10.76 0.39 6.06e-25 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs8180040 0.620 rs11720139 chr3:47036756 C/G cg16586182 chr3:47516702 SCAP 0.52 11.45 0.41 9.32e-28 Colorectal cancer; BRCA cis rs875971 0.862 rs7798630 chr7:65771479 G/C cg11764359 chr7:65958608 NA -0.75 -16.63 -0.55 7.22e-52 Aortic root size; BRCA cis rs9914544 1.000 rs1037036 chr17:18764077 C/T cg26306683 chr17:18585705 ZNF286B 0.38 9.51 0.35 3.7799999999999997e-20 Educational attainment (years of education); BRCA cis rs7737355 0.947 rs9327620 chr5:130996451 A/G cg06307176 chr5:131281290 NA 0.53 10.31 0.38 3.63e-23 Life satisfaction; BRCA cis rs6582630 0.502 rs10880092 chr12:38262965 A/T cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs796364 0.806 rs78037592 chr2:201105734 G/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -9.41 -0.35 8.95e-20 Schizophrenia; BRCA cis rs6912958 0.712 rs7772561 chr6:88331299 A/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.4 -0.32 2.9e-16 Monocyte percentage of white cells; BRCA cis rs7917772 0.503 rs746552 chr10:104342501 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 18.2 0.58 6.2e-60 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7666738 0.606 rs10006414 chr4:99101401 T/C cg05340658 chr4:99064831 C4orf37 0.49 10.75 0.39 6.73e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.636 rs77753517 chr8:58115897 C/T cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs698833 0.886 rs17580226 chr2:44570776 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.53 10.6 0.39 2.61e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg08470875 chr2:26401718 FAM59B 0.71 11.64 0.42 1.57e-28 Gut microbiome composition (summer); BRCA cis rs875971 0.522 rs34973832 chr7:65396204 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.45 10.13 0.37 1.88e-22 Aortic root size; BRCA cis rs7493 0.755 rs17883791 chr7:94999438 G/A cg17330251 chr7:94953956 PON1 -0.41 -8.58 -0.32 7.06e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs701145 0.938 rs355773 chr3:154036657 A/G cg17054900 chr3:154042577 DHX36 -0.66 -11.62 -0.42 1.88e-28 Coronary artery disease; BRCA cis rs2011503 0.882 rs4808958 chr19:19571752 G/A cg11584989 chr19:19387371 SF4 0.6 12.46 0.44 4.54e-32 Bipolar disorder; BRCA cis rs7131987 0.650 rs10843382 chr12:29451721 G/A cg09582351 chr12:29534625 ERGIC2 -0.47 -10.87 -0.39 2.36e-25 QT interval; BRCA trans rs3960554 0.808 rs78340819 chr7:75673833 C/G cg19862616 chr7:65841803 NCRNA00174 0.59 12.53 0.44 2.26e-32 Eotaxin levels; BRCA cis rs7666738 0.830 rs921522 chr4:98841608 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.66 0.5 3.8e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs250677 0.522 rs2895837 chr5:148357535 C/T cg12140854 chr5:148520817 ABLIM3 0.41 8.34 0.31 4.52e-16 Breast cancer; BRCA cis rs6582630 0.502 rs11181230 chr12:38300085 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.23 0.56 6.19e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs7618915 0.533 rs35107891 chr3:52613656 G/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.08 0.4 3.21e-26 Bipolar disorder; BRCA cis rs514406 0.679 rs960570 chr1:53237763 A/G cg08859206 chr1:53392774 SCP2 0.66 13.73 0.48 9.31e-38 Monocyte count; BRCA cis rs2836974 0.666 rs35182074 chr21:40685284 A/C cg11644478 chr21:40555479 PSMG1 -0.69 -14.91 -0.51 2.28e-43 Cognitive function; BRCA cis rs897080 0.515 rs1067362 chr2:44660112 A/C cg18685995 chr2:44588913 PREPL;C2orf34 0.44 8.08 0.3 3.33e-15 Height; BRCA cis rs13082711 0.520 rs2724494 chr3:27563920 C/A cg02860705 chr3:27208620 NA 0.43 8.55 0.32 8.9e-17 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs6598955 0.724 rs12096059 chr1:26596709 G/A cg00852783 chr1:26633632 UBXN11 0.56 13.61 0.47 3.2e-37 Obesity-related traits; BRCA cis rs9443645 0.901 rs4565265 chr6:79741958 A/G cg05283184 chr6:79620031 NA -0.43 -11.02 -0.4 5.89e-26 Intelligence (multi-trait analysis); BRCA trans rs9291683 0.507 rs3775940 chr4:10025163 A/T cg26043149 chr18:55253948 FECH 0.38 8.35 0.31 4.17e-16 Bone mineral density; BRCA trans rs6479891 1.000 rs9415680 chr10:65020890 A/G cg14819942 chr15:35414228 NA -0.34 -8.53 -0.32 1.03e-16 Arthritis (juvenile idiopathic); BRCA cis rs2797160 1.000 rs2797154 chr6:126005197 A/G cg05901451 chr6:126070800 HEY2 -0.39 -9.49 -0.35 4.46e-20 Endometrial cancer; BRCA cis rs1865760 0.593 rs3903852 chr6:25915147 G/T cg03264133 chr6:25882463 NA -0.41 -9.53 -0.35 3.13e-20 Height; BRCA cis rs3806843 1.000 rs3756342 chr5:140165624 G/A cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.67e-21 Depressive symptoms (multi-trait analysis); BRCA trans rs61931739 0.517 rs1844525 chr12:34103183 T/A cg13010199 chr12:38710504 ALG10B 0.48 9.23 0.34 3.94e-19 Morning vs. evening chronotype; BRCA cis rs911555 0.755 rs35233301 chr14:103885291 A/G cg12935359 chr14:103987150 CKB 0.61 14.06 0.49 2.59e-39 Intelligence (multi-trait analysis); BRCA cis rs7618915 0.547 rs11130317 chr3:52731483 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.96 0.37 8.25e-22 Bipolar disorder; BRCA cis rs12477438 0.798 rs2123686 chr2:99690135 G/A cg08885076 chr2:99613938 TSGA10 -0.52 -11.86 -0.42 1.85e-29 Chronic sinus infection; BRCA cis rs798554 0.686 rs7777484 chr7:2814271 A/G cg18446336 chr7:2847575 GNA12 -0.34 -7.94 -0.3 8.8e-15 Height; BRCA trans rs3857536 0.813 rs7766786 chr6:66932889 C/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.11 -0.31 2.53e-15 Blood trace element (Cu levels); BRCA cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg18230493 chr5:56204884 C5orf35 -0.74 -14.96 -0.51 1.3e-43 Initial pursuit acceleration; BRCA cis rs6089584 0.850 rs6142938 chr20:60627723 A/C cg06108461 chr20:60628389 TAF4 -1.01 -22.73 -0.67 2.96e-84 Body mass index; BRCA cis rs2304069 0.954 rs2340463 chr5:149409294 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.8 15.64 0.53 6.64e-47 HIV-1 control; BRCA cis rs12474201 0.822 rs897530 chr2:46948150 C/G cg06386533 chr2:46925753 SOCS5 0.83 17.95 0.58 1.25e-58 Height; BRCA cis rs17092148 0.945 rs6060034 chr20:33351864 T/C cg16810054 chr20:33298113 TP53INP2 -0.5 -11.26 -0.41 5.82e-27 Neuroticism; BRCA cis rs2120019 1.000 rs7175720 chr15:75348962 C/G cg11632617 chr15:75315747 PPCDC 0.4 8.7 0.33 2.83e-17 Blood trace element (Zn levels); BRCA cis rs858239 0.796 rs433395 chr7:23401955 G/T cg23682824 chr7:23144976 KLHL7 0.34 8.58 0.32 7.35e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.19 0.68 8.5e-87 Chronic sinus infection; BRCA cis rs9649465 0.967 rs598115 chr7:123402603 C/G cg04330084 chr7:123175371 IQUB 0.32 8.72 0.33 2.31e-17 Migraine; BRCA cis rs10504073 0.669 rs4493917 chr8:50015846 C/T cg00325661 chr8:49890786 NA 0.44 12.52 0.44 2.54e-32 Blood metabolite ratios; BRCA trans rs9388451 0.626 rs3799712 chr6:126075103 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -14.17 -0.49 7.78e-40 Brugada syndrome; BRCA cis rs9443645 0.901 rs1354832 chr6:79613763 A/G cg09184832 chr6:79620586 NA 0.49 10.68 0.39 1.25e-24 Intelligence (multi-trait analysis); BRCA cis rs514406 0.760 rs475969 chr1:53292607 T/A cg25767906 chr1:53392781 SCP2 -0.45 -10.06 -0.37 3.34e-22 Monocyte count; BRCA cis rs9796 0.621 rs1659227 chr15:41472398 G/A cg18705301 chr15:41695430 NDUFAF1 0.37 7.99 0.3 6.42e-15 Menopause (age at onset); BRCA cis rs13191362 0.935 rs73023493 chr6:162952769 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.52 8.33 0.31 4.95e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs61931739 0.534 rs12372557 chr12:34363843 C/T cg13010199 chr12:38710504 ALG10B 0.48 9.35 0.35 1.43e-19 Morning vs. evening chronotype; BRCA cis rs4631830 0.863 rs3101227 chr10:51520203 C/A cg20129853 chr10:51489980 NA -0.3 -8.12 -0.31 2.42e-15 Prostate-specific antigen levels; BRCA cis rs3806843 0.900 rs2337983 chr5:140136808 G/A cg16179182 chr5:140090404 VTRNA1-1 0.43 10.12 0.37 1.95e-22 Depressive symptoms (multi-trait analysis); BRCA cis rs2425143 1.000 rs733609 chr20:34393074 A/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -8.99 -0.34 2.73e-18 Blood protein levels; BRCA cis rs6570726 0.967 rs1396648 chr6:145785248 C/A cg23711669 chr6:146136114 FBXO30 -0.62 -14.03 -0.49 3.52e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs2197308 0.740 rs10880619 chr12:37922720 T/C cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5e-22 Morning vs. evening chronotype; BRCA cis rs7552404 0.961 rs1061337 chr1:76227022 A/G cg03433033 chr1:76189801 ACADM 0.75 16.46 0.55 5.41e-51 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs733592 0.560 rs2158515 chr12:48507668 T/C cg24011408 chr12:48396354 COL2A1 -0.43 -9.41 -0.35 8.59e-20 Plateletcrit; BRCA cis rs9291683 0.588 rs35099040 chr4:10018839 T/C cg02734326 chr4:10020555 SLC2A9 0.4 8.84 0.33 9.02e-18 Bone mineral density; BRCA cis rs6964587 1.000 rs11981461 chr7:91692662 A/G cg01689657 chr7:91764605 CYP51A1 0.22 8.05 0.3 3.98e-15 Breast cancer; BRCA cis rs1467026 0.719 rs17037220 chr3:12818103 A/G cg24848339 chr3:12840334 CAND2 0.43 11.14 0.4 1.78e-26 P wave duration; BRCA cis rs11098499 0.697 rs6832410 chr4:120296800 A/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA trans rs2727020 0.619 rs1829979 chr11:49436875 T/G cg15704280 chr7:45808275 SEPT13 -0.72 -14.33 -0.49 1.39e-40 Coronary artery disease; BRCA cis rs875971 0.862 rs10224872 chr7:65759773 T/A cg11764359 chr7:65958608 NA -0.77 -17.65 -0.57 4.23e-57 Aortic root size; BRCA cis rs1904096 0.506 rs10034781 chr4:95169682 A/C cg11021082 chr4:95130006 SMARCAD1 0.39 8.19 0.31 1.4e-15 Type 2 diabetes; BRCA cis rs10504229 0.906 rs61638902 chr8:58193511 A/C cg22535103 chr8:58192502 C8orf71 -0.58 -13.12 -0.46 5.72e-35 Developmental language disorder (linguistic errors); BRCA cis rs4689388 0.819 rs12649341 chr4:6294759 G/A cg00701064 chr4:6280414 WFS1 0.68 17.68 0.57 3.11e-57 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs4665809 1.000 rs6729080 chr2:26301282 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.64 -11.94 -0.43 7.99e-30 Gut microbiome composition (summer); BRCA cis rs10504073 0.527 rs118032023 chr8:49926296 A/T cg00325661 chr8:49890786 NA 0.47 13.78 0.48 4.99e-38 Blood metabolite ratios; BRCA cis rs1801251 1.000 rs7606090 chr2:233606740 T/C cg08000102 chr2:233561755 GIGYF2 0.63 14.03 0.49 3.74e-39 Coronary artery disease; BRCA cis rs4285028 0.747 rs9838301 chr3:121375144 G/T cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.77 -0.48 5.65e-38 Multiple sclerosis; BRCA cis rs2836633 0.895 rs2836598 chr21:40024758 C/G cg05519781 chr21:40033154 ERG 0.43 9.25 0.34 3.37e-19 Coronary artery disease; BRCA cis rs6088580 0.634 rs4911421 chr20:32998948 T/C cg24642439 chr20:33292090 TP53INP2 -0.54 -11.77 -0.42 4.23e-29 Glomerular filtration rate (creatinine); BRCA trans rs8073060 0.586 rs11080356 chr17:33895309 T/C cg19694781 chr19:47549865 TMEM160 1.01 21.86 0.65 1.58e-79 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9814567 1.000 rs4572812 chr3:134291177 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.61 0.32 5.85e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs79057730 0.599 rs35928068 chr7:805363 G/C cg11064039 chr7:766100 PRKAR1B;HEATR2 0.71 9.92 0.37 1.19e-21 Initial pursuit acceleration; BRCA cis rs4727027 0.704 rs12704070 chr7:148902789 G/A cg23583168 chr7:148888333 NA -0.97 -25.73 -0.71 9.71e-101 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6964587 0.692 rs418 chr7:91583334 C/T cg17063962 chr7:91808500 NA -0.55 -12.54 -0.44 2.13e-32 Breast cancer; BRCA cis rs2011503 1.000 rs4808968 chr19:19644402 C/T cg11584989 chr19:19387371 SF4 0.64 13.48 0.47 1.25e-36 Bipolar disorder; BRCA cis rs921968 0.565 rs2272188 chr2:219612282 C/T cg02176678 chr2:219576539 TTLL4 0.41 11.17 0.4 1.36e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs17270561 0.609 rs9379786 chr6:25730255 T/C cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs10504229 0.683 rs35889486 chr8:58117749 T/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs7520050 0.966 rs12410071 chr1:46358886 T/C cg24296786 chr1:45957014 TESK2 0.43 9.66 0.36 1.06e-20 Red blood cell count;Reticulocyte count; BRCA cis rs6460942 0.915 rs62448596 chr7:12446869 C/T cg10578991 chr7:12443926 VWDE -0.54 -7.96 -0.3 7.88e-15 Coronary artery disease; BRCA cis rs62064224 0.714 rs8074594 chr17:30632998 G/A cg25809561 chr17:30822961 MYO1D 0.4 9.52 0.35 3.36e-20 Schizophrenia; BRCA cis rs611744 0.604 rs13248461 chr8:109285833 C/T cg18478394 chr8:109455254 TTC35 0.27 7.84 0.3 1.86e-14 Dupuytren's disease; BRCA trans rs9858542 0.903 rs9875617 chr3:49634696 G/A cg21659725 chr3:3221576 CRBN -0.48 -10.21 -0.37 9.33e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7618915 0.501 rs3733039 chr3:52719088 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 12.97 0.46 2.51e-34 Bipolar disorder; BRCA cis rs2204008 0.807 rs11182461 chr12:38539288 T/C cg26384229 chr12:38710491 ALG10B 0.78 18.13 0.58 1.41e-59 Bladder cancer; BRCA cis rs7666738 0.800 rs2865988 chr4:99067807 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10089 1.000 rs2054444 chr5:127493206 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 -0.56 -12.7 -0.45 4.13e-33 Ileal carcinoids; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg09177884 chr7:1199841 ZFAND2A -0.56 -12.62 -0.45 9.61e-33 Longevity;Endometriosis; BRCA cis rs4919694 1.000 rs77827514 chr10:104822009 C/T cg04362960 chr10:104952993 NT5C2 0.95 14.72 0.5 1.85e-42 Arsenic metabolism; BRCA cis rs10484885 0.824 rs72919981 chr6:90528977 T/C cg13799429 chr6:90582589 CASP8AP2 -0.77 -9.79 -0.36 3.51e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7918232 0.882 rs2149413 chr10:27430311 C/T cg14442939 chr10:27389572 ANKRD26 -0.68 -10.76 -0.39 6.52e-25 Breast cancer; BRCA cis rs2629540 0.731 rs11245341 chr10:126408777 G/C cg08799069 chr10:126477246 METTL10 0.47 9.51 0.35 3.93e-20 Cocaine dependence; BRCA cis rs13108904 0.846 rs3775100 chr4:1225106 T/C cg02980000 chr4:1222292 CTBP1 -0.44 -8.72 -0.33 2.47e-17 Obesity-related traits; BRCA cis rs78707713 0.560 rs35060419 chr10:71229539 A/G cg12610070 chr10:71211762 TSPAN15 -0.32 -9.95 -0.37 8.77e-22 Venous thromboembolism; BRCA cis rs9790314 0.875 rs336582 chr3:161082659 C/T cg04691961 chr3:161091175 C3orf57 -0.58 -15.15 -0.51 1.58e-44 Morning vs. evening chronotype; BRCA trans rs35110281 0.744 rs162396 chr21:44947807 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.0 0.3 5.82e-15 Mean corpuscular volume; BRCA cis rs6570726 0.791 rs11155433 chr6:145907831 A/G cg13319975 chr6:146136371 FBXO30 0.39 9.12 0.34 9.44e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs8038465 0.615 rs62004618 chr15:73962164 A/G cg15420318 chr15:73925796 NPTN 0.42 9.33 0.35 1.67e-19 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2288073 0.801 rs10176347 chr2:24367994 G/A cg26838691 chr2:24397539 C2orf84 -0.46 -8.58 -0.32 7.39e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs911555 0.755 rs4143998 chr14:103955247 T/C cg24130564 chr14:104152367 KLC1 -0.39 -8.84 -0.33 8.97e-18 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.500 rs35251810 chr12:38577666 T/C cg26384229 chr12:38710491 ALG10B -0.45 -10.45 -0.38 1.01e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg26119090 chr2:26468346 HADHA;HADHB -0.75 -12.86 -0.45 8.08e-34 Gut microbiome composition (summer); BRCA cis rs9487051 0.735 rs351745 chr6:109529169 C/T cg01475377 chr6:109611718 NA 0.47 11.86 0.42 1.84e-29 Reticulocyte fraction of red cells; BRCA cis rs1506636 0.962 rs7811830 chr7:123320183 G/C cg03229431 chr7:123269106 ASB15 -0.62 -14.07 -0.49 2.4e-39 Plateletcrit;Platelet count; BRCA cis rs2832191 0.935 rs67287920 chr21:30523519 C/A cg24692254 chr21:30365293 RNF160 -0.6 -15.71 -0.53 2.77e-47 Dental caries; BRCA cis rs12477438 0.520 rs13009147 chr2:99803998 T/G cg08885076 chr2:99613938 TSGA10 0.45 10.48 0.38 7.93e-24 Chronic sinus infection; BRCA trans rs78049276 0.736 rs6842241 chr4:148400819 C/A cg13149281 chr14:23389818 RBM23;PRMT5 -0.42 -8.06 -0.3 3.88e-15 Pulse pressure; BRCA cis rs17270561 0.609 rs4711098 chr6:25734339 C/T cg16482183 chr6:26056742 HIST1H1C 0.46 8.91 0.33 5.22e-18 Iron status biomarkers; BRCA cis rs17445774 1.000 rs17445774 chr2:200859249 A/G cg23649088 chr2:200775458 C2orf69 -0.55 -9.85 -0.36 2.09e-21 LDL cholesterol to HDL cholesterol ratio; BRCA cis rs67460515 0.630 rs7638370 chr3:160921793 G/T cg17135325 chr3:160939158 NMD3 0.44 8.47 0.32 1.74e-16 Parkinson's disease; BRCA cis rs8010715 0.848 rs8009511 chr14:24593980 G/A cg23112188 chr14:24563095 PCK2 -0.33 -8.28 -0.31 7.35e-16 IgG glycosylation; BRCA cis rs6005807 0.719 rs12169071 chr22:29033210 C/G cg12565055 chr22:29076175 TTC28 0.49 9.36 0.35 1.35e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs9880211 0.800 rs9873536 chr3:136474267 A/G cg21827317 chr3:136751795 NA -0.45 -7.81 -0.3 2.28e-14 Body mass index;Height; BRCA cis rs17253792 0.822 rs79022053 chr14:56071721 A/G cg24579896 chr14:56047964 C14orf33;KTN1 0.6 8.13 0.31 2.23e-15 Putamen volume; BRCA cis rs10197940 0.578 rs2045025 chr2:152317531 T/C cg06191203 chr2:152266755 RIF1 -0.27 -8.11 -0.31 2.62e-15 Lung cancer; BRCA cis rs9986765 1.000 rs28672333 chr7:142826798 G/A cg21852589 chr7:142981689 TMEM139 0.56 9.68 0.36 9.12e-21 Cancer;Dermatomyositis; BRCA cis rs826838 1.000 rs1719830 chr12:39096992 T/G cg13010199 chr12:38710504 ALG10B -0.42 -9.89 -0.36 1.52e-21 Heart rate; BRCA cis rs2836974 0.533 rs418298 chr21:40536654 A/T cg22974920 chr21:40686053 BRWD1 0.37 8.43 0.32 2.26e-16 Cognitive function; BRCA cis rs4665809 1.000 rs4665305 chr2:26313524 C/T cg25036284 chr2:26402008 FAM59B -0.64 -10.97 -0.4 8.71e-26 Gut microbiome composition (summer); BRCA cis rs11779988 0.545 rs436506 chr8:17798243 A/G cg01800426 chr8:17659068 MTUS1 0.42 8.26 0.31 8.27e-16 Breast cancer; BRCA cis rs8114671 0.562 rs2273683 chr20:33509523 C/T cg07148914 chr20:33460835 GGT7 0.48 10.33 0.38 3e-23 Height; BRCA cis rs4563143 0.634 rs113736470 chr19:29240125 G/A cg03161606 chr19:29218774 NA 0.44 7.89 0.3 1.33e-14 Methadone dose in opioid dependence; BRCA cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg03709012 chr19:19516395 GATAD2A 0.74 16.3 0.54 3.28e-50 Tonsillectomy; BRCA cis rs9649213 0.593 rs736754 chr7:97931559 C/T cg21770322 chr7:97807741 LMTK2 0.42 11.27 0.41 5.33e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs7819412 0.595 rs4841500 chr8:10988275 A/G cg15556689 chr8:8085844 FLJ10661 -0.36 -9.33 -0.35 1.7e-19 Triglycerides; BRCA cis rs1371867 0.846 rs2047249 chr8:101234126 A/G cg06002616 chr8:101225028 SPAG1 0.35 8.69 0.33 3.04e-17 Atrioventricular conduction; BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg05457628 chr5:178986728 RUFY1 -0.39 -9.07 -0.34 1.44e-18 Lung cancer; BRCA cis rs3815700 0.920 rs10424732 chr19:33096487 C/T cg02997394 chr19:33096574 ANKRD27 0.68 11.25 0.41 6.55e-27 Eosinophilic esophagitis; BRCA cis rs4808199 0.894 rs9304960 chr19:19465529 G/A cg03709012 chr19:19516395 GATAD2A 1.0 18.84 0.6 2.65e-63 Nonalcoholic fatty liver disease; BRCA cis rs7772486 0.875 rs1412081 chr6:146409733 A/G cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.04e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6714710 0.603 rs2044458 chr2:98377512 A/T cg26665480 chr2:98280029 ACTR1B 0.56 13.05 0.46 1.11e-34 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs1568889 1.000 rs1464897 chr11:28034844 C/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.67 14.58 0.5 8.73e-42 Bipolar disorder; BRCA cis rs2516839 0.652 rs2774276 chr1:161011716 G/C cg19284575 chr1:160991224 F11R -0.45 -8.14 -0.31 2.14e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs7572263 0.724 rs12986551 chr2:209052303 T/C cg23998903 chr2:209048830 C2orf80 -0.42 -8.68 -0.32 3.16e-17 Glioma;Non-glioblastoma glioma; BRCA cis rs40363 0.645 rs250627 chr16:3527050 G/A cg00484396 chr16:3507460 NAT15 0.42 8.52 0.32 1.12e-16 Tuberculosis; BRCA cis rs754466 0.606 rs10824581 chr10:79599501 A/G cg17075019 chr10:79541650 NA -0.82 -19.6 -0.61 2.45e-67 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs2075371 0.796 rs1646645 chr7:134012232 G/T cg02659138 chr7:134003124 SLC35B4 -0.32 -10.2 -0.37 9.66e-23 Mean platelet volume; BRCA cis rs12477438 0.520 rs11123764 chr2:99750677 T/C cg08885076 chr2:99613938 TSGA10 0.46 10.9 0.4 1.66e-25 Chronic sinus infection; BRCA cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg18876405 chr7:65276391 NA 0.62 15.18 0.51 1.09e-44 Aortic root size; BRCA cis rs9487051 0.768 rs12176068 chr6:109521629 C/T cg21918786 chr6:109611834 NA -0.35 -9.24 -0.34 3.73e-19 Reticulocyte fraction of red cells; BRCA trans rs208520 0.955 rs208532 chr6:66961280 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -14.55 -0.5 1.17e-41 Exhaled nitric oxide output; BRCA cis rs4862750 0.914 rs1346126 chr4:187876404 T/C cg22105103 chr4:187893119 NA 0.38 11.76 0.42 5.02e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs2120019 0.938 rs8036573 chr15:75308690 C/T cg11632617 chr15:75315747 PPCDC -0.38 -8.39 -0.32 3.01e-16 Blood trace element (Zn levels); BRCA cis rs6973256 0.865 rs1133540 chr7:133346380 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.94 -0.33 4.2e-18 Intelligence (multi-trait analysis); BRCA cis rs13095912 0.752 rs9758141 chr3:185315085 A/T cg11274856 chr3:185301563 NA 0.55 13.27 0.46 1.08e-35 Systolic blood pressure; BRCA cis rs7246657 0.722 rs12979640 chr19:38179156 T/C cg18154014 chr19:37997991 ZNF793 -0.46 -8.79 -0.33 1.34e-17 Coronary artery calcification; BRCA trans rs7819412 0.595 rs10503416 chr8:10987553 C/T cg06636001 chr8:8085503 FLJ10661 0.47 9.9 0.36 1.3e-21 Triglycerides; BRCA cis rs17270561 0.943 rs76703022 chr6:25703529 A/C cg17691542 chr6:26056736 HIST1H1C 0.64 11.21 0.41 9.32e-27 Iron status biomarkers; BRCA cis rs7811142 0.943 rs67483801 chr7:100031758 G/T cg11814155 chr7:99998594 ZCWPW1 0.43 8.07 0.3 3.38e-15 Platelet count; BRCA cis rs6594713 0.717 rs17331844 chr5:112914426 G/T cg12552261 chr5:112820674 MCC 0.48 8.22 0.31 1.18e-15 Brain cytoarchitecture; BRCA cis rs4631830 0.600 rs11004324 chr10:51496623 G/T cg20129853 chr10:51489980 NA -0.31 -7.84 -0.3 1.87e-14 Prostate-specific antigen levels; BRCA cis rs1005277 0.579 rs9299760 chr10:38377920 C/T cg25427524 chr10:38739819 LOC399744 -0.7 -16.88 -0.56 4.06e-53 Extrinsic epigenetic age acceleration; BRCA cis rs9926296 0.581 rs6500457 chr16:89898764 C/G cg26513180 chr16:89883248 FANCA -0.57 -13.03 -0.46 1.45e-34 Vitiligo; BRCA cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg06808227 chr14:105710500 BRF1 -0.8 -15.93 -0.53 2.39e-48 Mean platelet volume;Platelet distribution width; BRCA trans rs12310956 0.510 rs2054867 chr12:33835462 C/G cg26384229 chr12:38710491 ALG10B -0.41 -9.59 -0.35 2e-20 Morning vs. evening chronotype; BRCA cis rs1878931 0.501 rs42329 chr16:3425524 G/A cg26668626 chr16:3451006 ZNF174;ZNF434 -0.62 -12.11 -0.43 1.52e-30 Body mass index (adult); BRCA cis rs11098499 0.754 rs66900435 chr4:120249425 C/A cg09307838 chr4:120376055 NA 0.64 13.8 0.48 4.09e-38 Corneal astigmatism; BRCA cis rs2404602 0.684 rs157759 chr15:76846990 T/A cg23625390 chr15:77176239 SCAPER 0.54 13.77 0.48 5.76e-38 Blood metabolite levels; BRCA cis rs7618915 0.547 rs11130315 chr3:52697163 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 3.02e-25 Bipolar disorder; BRCA cis rs1030877 0.889 rs2576746 chr2:105909559 G/A cg02079111 chr2:105885981 TGFBRAP1 0.71 17.42 0.57 6.66e-56 Obesity-related traits; BRCA cis rs7772486 0.566 rs735536 chr6:146036832 A/C cg23711669 chr6:146136114 FBXO30 -0.71 -16.79 -0.55 1.13e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs10876993 0.890 rs7976852 chr12:58100551 T/G cg18357645 chr12:58087776 OS9 0.44 12.49 0.44 3.5e-32 Celiac disease or Rheumatoid arthritis; BRCA cis rs7586879 0.828 rs4077677 chr2:25122798 G/C cg04586622 chr2:25135609 ADCY3 0.4 9.55 0.35 2.77e-20 Body mass index; BRCA cis rs1127311 0.905 rs6702449 chr1:154583210 A/C cg17218026 chr1:154582156 ADAR 0.28 8.68 0.32 3.27e-17 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs4285028 0.948 rs71329246 chr3:121680170 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.71 -0.39 1.03e-24 Multiple sclerosis; BRCA cis rs11955398 0.585 rs4524466 chr5:60020078 C/T cg02684056 chr5:59996105 DEPDC1B -0.37 -8.94 -0.33 4.21e-18 Intelligence (multi-trait analysis); BRCA cis rs7072216 0.763 rs6584204 chr10:100173580 C/G cg26618903 chr10:100175079 PYROXD2 -0.33 -9.63 -0.36 1.35e-20 Metabolite levels; BRCA cis rs7811142 0.830 rs6948685 chr7:99970188 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.51 0.44 2.7e-32 Platelet count; BRCA cis rs8062405 0.895 rs62036658 chr16:28850371 T/G cg09754948 chr16:28834200 ATXN2L 0.47 8.6 0.32 6.33e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs4689592 0.503 rs11945642 chr4:7051065 G/C cg07817883 chr1:32538562 TMEM39B 0.5 8.96 0.33 3.63e-18 Monocyte percentage of white cells; BRCA trans rs7647973 0.626 rs11709734 chr3:49745235 G/A cg21659725 chr3:3221576 CRBN -0.48 -8.87 -0.33 7.34e-18 Menarche (age at onset); BRCA cis rs858239 0.600 rs7789237 chr7:23124713 T/G cg23682824 chr7:23144976 KLHL7 0.45 11.83 0.42 2.53e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs10504229 0.728 rs17804624 chr8:58154216 T/C cg22535103 chr8:58192502 C8orf71 -0.47 -8.34 -0.31 4.47e-16 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg20607798 chr8:58055168 NA -0.54 -8.3 -0.31 6.13e-16 Developmental language disorder (linguistic errors); BRCA cis rs8072100 0.738 rs9895509 chr17:45549618 A/T cg25173405 chr17:45401733 C17orf57 0.49 10.18 0.37 1.21e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7666738 0.830 rs4699588 chr4:98973789 A/G cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs72960926 0.744 rs72964214 chr6:74864851 T/C cg03266952 chr6:74778945 NA -0.67 -8.02 -0.3 5.06e-15 Metabolite levels (MHPG); BRCA cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -10.24 -0.38 6.96e-23 Mean corpuscular volume; BRCA trans rs208515 0.592 rs10944862 chr6:66674215 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 16.05 0.54 5.66e-49 Exhaled nitric oxide levels; BRCA cis rs7267979 1.000 rs6050562 chr20:25336186 C/G cg08601574 chr20:25228251 PYGB -0.35 -8.56 -0.32 8.27e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6701037 0.625 rs72719370 chr1:175128536 G/C cg14847009 chr1:175162515 KIAA0040 -0.25 -9.45 -0.35 6.06e-20 Alcohol dependence; BRCA cis rs2276314 1.000 rs58054756 chr18:33554053 G/C cg05985134 chr18:33552581 C18orf21 0.69 13.25 0.46 1.44e-35 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1355223 0.506 rs1509660 chr11:34865017 A/G cg11058730 chr11:34937778 PDHX;APIP -0.49 -9.5 -0.35 4.21e-20 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs701145 0.556 rs355787 chr3:153994502 T/C cg16511985 chr3:153974050 SGEF 0.46 10.62 0.39 2.21e-24 Coronary artery disease; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00908189 chr16:619842 PIGQ 0.7 17.69 0.57 2.7e-57 Height; BRCA cis rs3806843 0.933 rs10069930 chr5:140163328 T/A cg11822812 chr5:140052017 DND1 0.29 7.99 0.3 6.23e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs7959452 0.536 rs4761237 chr12:69776461 C/G cg14784868 chr12:69753453 YEATS4 0.68 19.91 0.62 5.54e-69 Blood protein levels; BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg08067268 chr2:26466485 HADHB;HADHA 0.59 10.15 0.37 1.51e-22 Gut microbiome composition (summer); BRCA cis rs4665809 1.000 rs17040322 chr2:26351274 G/C cg08470875 chr2:26401718 FAM59B -0.5 -8.17 -0.31 1.65e-15 Gut microbiome composition (summer); BRCA cis rs6088590 1.000 rs6119512 chr20:33306904 T/C cg06115741 chr20:33292138 TP53INP2 0.51 11.32 0.41 3.29e-27 Coronary artery disease; BRCA cis rs12579753 0.917 rs12366599 chr12:82212112 C/T cg07988820 chr12:82153109 PPFIA2 -0.46 -7.99 -0.3 6.3e-15 Resting heart rate; BRCA cis rs6973256 0.897 rs1041621 chr7:133353965 A/G cg07491979 chr7:133331646 EXOC4 0.4 9.11 0.34 1.06e-18 Intelligence (multi-trait analysis); BRCA trans rs7939886 0.920 rs1552151 chr11:55780951 A/G cg15704280 chr7:45808275 SEPT13 -0.62 -8.08 -0.3 3.18e-15 Myopia (pathological); BRCA cis rs921968 0.612 rs496908 chr2:219357742 A/T cg02176678 chr2:219576539 TTLL4 0.42 10.98 0.4 8.25e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs897080 0.515 rs1067366 chr2:44655094 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 9.16 0.34 7.05e-19 Height; BRCA cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs17345786 0.817 rs11720560 chr3:101328484 C/T cg11279151 chr3:101281821 RG9MTD1 -0.49 -10.6 -0.39 2.75e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4718428 0.705 rs4717331 chr7:66378886 C/T cg12165864 chr7:66369176 NA -0.45 -10.29 -0.38 4.56e-23 Corneal structure; BRCA cis rs35110281 0.805 rs8131005 chr21:45041954 T/C cg04455712 chr21:45112962 RRP1B 0.41 11.18 0.4 1.28e-26 Mean corpuscular volume; BRCA cis rs67311347 1.000 rs73080138 chr3:40516417 A/G cg24209194 chr3:40518798 ZNF619 0.38 7.85 0.3 1.74e-14 Renal cell carcinoma; BRCA cis rs7208859 0.623 rs9914242 chr17:29216245 G/T cg13385521 chr17:29058706 SUZ12P 0.6 8.4 0.32 2.98e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg05985134 chr18:33552581 C18orf21 0.64 11.51 0.41 5.2e-28 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6433895 0.667 rs35702511 chr2:182018106 G/A cg00481216 chr2:181971175 NA 0.43 8.06 0.3 3.8e-15 Lymphocyte counts; BRCA cis rs739401 0.572 rs389128 chr11:3083873 G/T cg08508325 chr11:3079039 CARS -0.44 -15.71 -0.53 2.97e-47 Longevity; BRCA cis rs2742234 0.578 rs2742241 chr10:43625223 G/A cg15436174 chr10:43711423 RASGEF1A -0.51 -10.46 -0.38 9.22e-24 Hirschsprung disease; BRCA cis rs921968 0.565 rs62191658 chr2:219630294 A/G cg02176678 chr2:219576539 TTLL4 -0.41 -11.0 -0.4 6.78e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs7586879 0.828 rs9631061 chr2:25109804 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.55 0.35 2.71e-20 Body mass index; BRCA cis rs61931739 0.500 rs7306053 chr12:34510848 T/G cg06521331 chr12:34319734 NA -0.52 -10.17 -0.37 1.26e-22 Morning vs. evening chronotype; BRCA trans rs2797160 0.967 rs1954360 chr6:126001064 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.07e-14 Endometrial cancer; BRCA cis rs12586317 0.620 rs17091786 chr14:35565856 A/T cg16230307 chr14:35515116 FAM177A1 0.73 14.7 0.5 2.46e-42 Psoriasis; BRCA cis rs3820928 1.000 rs2163041 chr2:227772480 T/C cg11843606 chr2:227700838 RHBDD1 -0.38 -8.41 -0.32 2.72e-16 Pulmonary function; BRCA cis rs10911232 0.507 rs4369195 chr1:182996291 G/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.69 0.55 3.67e-52 Hypertriglyceridemia; BRCA cis rs7412746 0.621 rs72704656 chr1:150828307 A/G cg18016565 chr1:150552671 MCL1 0.34 7.9 0.3 1.23e-14 Melanoma; BRCA cis rs3617 0.573 rs9860296 chr3:52913781 A/G cg11645453 chr3:52864694 ITIH4 0.34 8.79 0.33 1.39e-17 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs6089829 0.962 rs2277769 chr20:61666805 C/T cg08045932 chr20:61659980 NA 0.48 11.27 0.41 5.19e-27 Prostate cancer (SNP x SNP interaction); BRCA cis rs9311474 0.508 rs1570 chr3:52586682 T/A cg10802521 chr3:52805072 NEK4 -0.31 -8.44 -0.32 2.08e-16 Electroencephalogram traits; BRCA cis rs495337 0.720 rs6067274 chr20:48544386 G/A cg17835207 chr20:48524531 SPATA2 -0.69 -16.8 -0.55 1.04e-52 Psoriasis; BRCA cis rs9291683 0.595 rs11722930 chr4:10035454 G/A cg11266682 chr4:10021025 SLC2A9 0.49 12.86 0.45 8.33e-34 Bone mineral density; BRCA cis rs1862618 0.526 rs2591963 chr5:56237135 T/A cg24549020 chr5:56110836 MAP3K1 -0.58 -10.61 -0.39 2.48e-24 Initial pursuit acceleration; BRCA trans rs1459104 1.000 rs34391788 chr11:55271721 C/A cg15704280 chr7:45808275 SEPT13 0.65 8.14 0.31 2.12e-15 Body mass index; BRCA cis rs4671400 0.571 rs62152270 chr2:61494260 C/A cg15711740 chr2:61764176 XPO1 0.4 7.94 0.3 8.94e-15 3-hydroxypropylmercapturic acid levels in smokers; BRCA cis rs8180040 0.726 rs10461018 chr3:46995242 C/T cg16586182 chr3:47516702 SCAP 0.51 11.18 0.4 1.21e-26 Colorectal cancer; BRCA cis rs9811920 0.625 rs7631174 chr3:99913902 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 8.62 0.32 5.11e-17 Axial length; BRCA cis rs8072100 0.902 rs12051716 chr17:45582395 G/A cg08085267 chr17:45401833 C17orf57 0.58 12.1 0.43 1.68e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs8177253 1.000 rs8177271 chr3:133482230 G/A cg01448562 chr3:133502909 NA -0.64 -15.27 -0.52 4.38e-45 Iron status biomarkers; BRCA cis rs3820928 0.874 rs4461255 chr2:227846524 C/T cg11843606 chr2:227700838 RHBDD1 0.38 8.51 0.32 1.27e-16 Pulmonary function; BRCA cis rs7918232 0.941 rs788210 chr10:27476948 T/C cg14240646 chr10:27532245 ACBD5 0.64 9.5 0.35 4.29e-20 Breast cancer; BRCA cis rs1949733 0.636 rs16842498 chr4:8539529 C/T cg13073564 chr4:8508604 NA 0.31 7.81 0.3 2.33e-14 Response to antineoplastic agents; BRCA cis rs11098499 0.954 rs13113483 chr4:120309039 C/T cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA cis rs7945705 0.747 rs1123936 chr11:9003306 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.6 -14.38 -0.49 7.77e-41 Hemoglobin concentration; BRCA cis rs4925386 0.802 rs6142735 chr20:60918087 G/C cg24112000 chr20:60950667 NA -0.52 -9.81 -0.36 2.91e-21 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs6138458 1.000 rs227627 chr20:24912107 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.39 -0.31 3.15e-16 Blood protein levels; BRCA cis rs4363385 0.747 rs1577965 chr1:152968294 T/C cg24667326 chr1:152973720 SPRR3 -0.35 -9.66 -0.36 1.03e-20 Inflammatory skin disease; BRCA cis rs769267 0.825 rs1469713 chr19:19528806 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.9 0.33 5.7e-18 Tonsillectomy; BRCA cis rs6582630 0.502 rs10880388 chr12:38401341 A/T cg13010199 chr12:38710504 ALG10B 0.5 10.3 0.38 4.14e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2404602 0.967 rs2083762 chr15:76907376 T/C cg26408565 chr15:76604113 ETFA -0.39 -8.41 -0.32 2.66e-16 Blood metabolite levels; BRCA cis rs7737355 1.000 rs12719444 chr5:130607378 C/T cg06307176 chr5:131281290 NA 0.46 8.81 0.33 1.19e-17 Life satisfaction; BRCA cis rs3784262 0.669 rs12915989 chr15:58315736 C/A cg12031962 chr15:58353849 ALDH1A2 -0.37 -10.12 -0.37 2.03e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs16958440 0.737 rs16958699 chr18:44654846 T/C cg17192377 chr18:44677553 HDHD2 0.68 10.01 0.37 5.3e-22 Sitting height ratio; BRCA cis rs8054556 0.633 rs12928610 chr16:30016022 C/T cg06326092 chr16:30034487 C16orf92 0.36 9.19 0.34 5.38e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs13256369 0.851 rs11249889 chr8:8564992 G/T cg18904891 chr8:8559673 CLDN23 0.65 13.06 0.46 1.02e-34 Obesity-related traits; BRCA cis rs7560272 0.512 rs12998980 chr2:73930726 A/C cg20560298 chr2:73613845 ALMS1 0.35 9.05 0.34 1.75e-18 Schizophrenia; BRCA cis rs1595825 0.891 rs78835808 chr2:198669110 G/A cg19156104 chr2:198669113 PLCL1 -0.48 -8.58 -0.32 7.39e-17 Ulcerative colitis; BRCA trans rs75804782 0.521 rs56340711 chr2:239440080 A/T cg01134436 chr17:81009848 B3GNTL1 0.69 8.99 0.34 2.69e-18 Morning vs. evening chronotype;Chronotype; BRCA trans rs9291683 0.530 rs10939620 chr4:9946132 C/T cg26043149 chr18:55253948 FECH -0.4 -9.01 -0.34 2.28e-18 Bone mineral density; BRCA cis rs875971 0.545 rs4718335 chr7:65804606 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.13 0.37 1.82e-22 Aortic root size; BRCA cis rs2836950 0.565 rs2836934 chr21:40564885 A/C cg11644478 chr21:40555479 PSMG1 -0.52 -10.97 -0.4 9.31e-26 Menarche (age at onset); BRCA cis rs13064411 0.696 rs36054418 chr3:113204762 G/T cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs1580019 0.922 rs1376289 chr7:32486980 C/G cg06627557 chr7:32535165 LSM5;AVL9 -0.88 -19.17 -0.6 4.81e-65 Cognitive ability; BRCA cis rs2836974 0.897 rs34599551 chr21:40594898 C/A cg11644478 chr21:40555479 PSMG1 0.87 20.89 0.64 2.94e-74 Cognitive function; BRCA cis rs2204008 0.837 rs11172728 chr12:38070042 C/A cg26384229 chr12:38710491 ALG10B 0.66 15.19 0.52 1.03e-44 Bladder cancer; BRCA trans rs9291683 0.530 rs35908990 chr4:9976105 G/A cg26043149 chr18:55253948 FECH 0.4 8.86 0.33 7.83e-18 Bone mineral density; BRCA cis rs17270561 0.609 rs1318016 chr6:25764704 A/T cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs672059 1.000 rs547905 chr1:183157924 G/A ch.1.3577855R chr1:183094577 LAMC1 0.38 8.64 0.32 4.62e-17 Hypertriglyceridemia; BRCA cis rs1707322 0.964 rs785496 chr1:46588006 T/C cg03146154 chr1:46216737 IPP -0.45 -9.49 -0.35 4.35e-20 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.853 rs252919 chr5:56124111 T/C cg24531977 chr5:56204891 C5orf35 -0.86 -18.03 -0.58 4.63e-59 Initial pursuit acceleration; BRCA cis rs9926296 0.744 rs164746 chr16:89709019 C/T cg01097406 chr16:89675127 NA 0.52 9.31 0.35 1.97e-19 Vitiligo; BRCA cis rs2070488 1.000 rs13079757 chr3:38491444 C/T cg24069376 chr3:38537580 EXOG 0.41 11.94 0.43 8.01e-30 Electrocardiographic conduction measures; BRCA cis rs6867032 0.527 rs13162781 chr5:2012235 C/T cg26168224 chr5:2018326 NA 0.44 11.91 0.43 1.13e-29 Gut microbiome composition (winter); BRCA cis rs77106637 0.860 rs11603334 chr11:72432985 G/A cg03713592 chr11:72463424 ARAP1 1.14 16.86 0.55 5.06e-53 Type 2 diabetes; BRCA cis rs1707322 1.000 rs4606257 chr1:46307268 G/A cg06784218 chr1:46089804 CCDC17 0.49 11.82 0.42 2.75e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7592578 0.639 rs61709084 chr2:191287685 A/C cg11845111 chr2:191398756 TMEM194B -0.71 -13.61 -0.47 3.01e-37 Diastolic blood pressure; BRCA cis rs1557765 0.527 rs10832782 chr11:17397273 G/C cg15432903 chr11:17409602 KCNJ11 0.41 8.78 0.33 1.46e-17 Body mass index;Social communication problems; BRCA cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.97 0.3 7.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7267979 1.000 rs3002702 chr20:25268920 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.62 0.36 1.54e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7246657 0.722 rs10402671 chr19:38117086 C/T cg23950597 chr19:37808831 NA -0.49 -8.51 -0.32 1.28e-16 Coronary artery calcification; BRCA cis rs35740288 0.929 rs1978391 chr15:86311695 A/G cg20737812 chr15:86336631 KLHL25 0.34 8.5 0.32 1.31e-16 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs11252926 0.801 rs11252332 chr10:467318 A/T cg18196295 chr10:418757 DIP2C 0.49 10.45 0.38 1.08e-23 Psychosis in Alzheimer's disease; BRCA cis rs12618769 0.652 rs3769708 chr2:99187650 T/C cg10123293 chr2:99228465 UNC50 0.43 8.55 0.32 9.39e-17 Bipolar disorder; BRCA cis rs7666738 0.830 rs7684646 chr4:99071062 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.32 0.57 2.24e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11644478 chr21:40555479 PSMG1 0.85 19.82 0.62 1.71e-68 Cognitive function; BRCA cis rs72781680 0.611 rs7602797 chr2:24318148 C/T cg08917208 chr2:24149416 ATAD2B 0.52 8.21 0.31 1.21e-15 Lymphocyte counts; BRCA cis rs826838 0.967 rs11183622 chr12:38792849 T/C cg13010199 chr12:38710504 ALG10B 0.54 11.98 0.43 5.39e-30 Heart rate; BRCA cis rs332507 0.830 rs35816663 chr3:124405513 G/T cg05980111 chr3:124395277 KALRN 0.37 8.65 0.32 4.31e-17 Plateletcrit; BRCA cis rs2836950 0.501 rs4818019 chr21:40694456 T/A cg17971929 chr21:40555470 PSMG1 -0.48 -10.5 -0.38 6.57e-24 Menarche (age at onset); BRCA cis rs13256369 0.951 rs13260947 chr8:8565883 A/G cg17143192 chr8:8559678 CLDN23 0.56 10.93 0.4 1.29e-25 Obesity-related traits; BRCA trans rs9858542 0.953 rs35169793 chr3:49423274 A/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.37 -9.05 -0.34 1.73e-18 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs13064411 0.696 rs6808394 chr3:113122524 T/G cg18753928 chr3:113234510 CCDC52 -0.51 -9.53 -0.35 3.14e-20 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs250677 1.000 rs28173 chr5:148423573 C/T cg23229984 chr5:148520753 ABLIM3 0.32 7.89 0.3 1.29e-14 Breast cancer; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg18402987 chr7:1209562 NA 0.51 9.81 0.36 3.02e-21 Longevity;Endometriosis; BRCA cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg23625390 chr15:77176239 SCAPER 0.39 9.25 0.34 3.3e-19 Blood metabolite levels; BRCA cis rs6912958 0.781 rs2268993 chr6:88184111 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.5 -0.32 1.38e-16 Monocyte percentage of white cells; BRCA cis rs6831352 0.703 rs2602862 chr4:100033221 A/G cg13256891 chr4:100009986 ADH5 0.5 10.33 0.38 3.21e-23 Alcohol dependence; BRCA cis rs8103278 1.000 rs9807819 chr19:46239598 C/T cg11657440 chr19:46296263 DMWD -0.57 -13.82 -0.48 3.25e-38 Coronary artery disease; BRCA cis rs6912958 0.781 rs2325064 chr6:88224467 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.3 -8.33 -0.31 5.02e-16 Monocyte percentage of white cells; BRCA cis rs8031584 0.541 rs2959037 chr15:31218164 T/C cg14829155 chr15:31115871 NA 0.41 9.99 0.37 6.26e-22 Huntington's disease progression; BRCA cis rs6867032 1.000 rs4413568 chr5:2016894 A/G cg26168224 chr5:2018326 NA 0.65 18.95 0.6 7.32e-64 Gut microbiome composition (winter); BRCA trans rs11088226 0.681 rs1015047 chr21:33949423 A/G cg09050820 chr6:167586206 TCP10L2 0.86 15.87 0.53 4.7e-48 Gastritis; BRCA trans rs9291683 0.609 rs55959894 chr4:10026580 G/A cg26043149 chr18:55253948 FECH 0.41 8.83 0.33 9.63e-18 Bone mineral density; BRCA cis rs6860806 0.507 rs200837 chr5:131699958 G/A cg24060327 chr5:131705240 SLC22A5 -0.6 -11.43 -0.41 1.16e-27 Breast cancer; BRCA cis rs7903847 0.642 rs11189175 chr10:99139609 T/C cg08345082 chr10:99160200 RRP12 -0.29 -8.62 -0.32 5.4e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs708547 0.836 rs1625691 chr4:57845740 T/C cg25525207 chr4:57843836 C4orf14;POLR2B -0.55 -10.78 -0.39 5.36e-25 Response to bleomycin (chromatid breaks); BRCA cis rs1707322 0.964 rs785509 chr1:46527300 G/A cg03146154 chr1:46216737 IPP -0.45 -9.89 -0.36 1.53e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2842992 0.513 rs7759086 chr6:160193853 A/G cg27624424 chr6:160112604 SOD2 0.39 8.26 0.31 8.65e-16 Age-related macular degeneration (geographic atrophy); BRCA cis rs7666738 0.570 rs1869351 chr4:99077286 T/C cg05340658 chr4:99064831 C4orf37 0.49 10.73 0.39 8.4e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs7267979 1.000 rs2027004 chr20:25350618 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.32 -8.56 -0.32 8.25e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10493773 0.962 rs6698578 chr1:86236676 G/A cg17807903 chr1:86174739 ZNHIT6 -0.47 -9.72 -0.36 6.14e-21 Urate levels in overweight individuals; BRCA cis rs8062405 0.721 rs151181 chr16:28490517 A/G cg16576597 chr16:28551801 NUPR1 0.3 8.19 0.31 1.38e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs2204008 0.782 rs11514339 chr12:38236670 G/A cg06521331 chr12:34319734 NA -0.52 -9.41 -0.35 8.45e-20 Bladder cancer; BRCA trans rs61931739 0.635 rs6488185 chr12:33933127 G/C cg26384229 chr12:38710491 ALG10B 0.4 8.97 0.33 3.18e-18 Morning vs. evening chronotype; BRCA cis rs17270561 0.609 rs1937131 chr6:25744831 A/T cg17691542 chr6:26056736 HIST1H1C -0.43 -8.35 -0.31 4.34e-16 Iron status biomarkers; BRCA trans rs208515 0.525 rs10755508 chr6:66675790 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 14.54 0.5 1.32e-41 Exhaled nitric oxide levels; BRCA cis rs2836974 0.965 rs8130984 chr21:40639966 A/C cg17971929 chr21:40555470 PSMG1 0.79 18.51 0.59 1.46e-61 Cognitive function; BRCA cis rs2032447 0.933 rs4401650 chr6:26035208 G/A cg18357526 chr6:26021779 HIST1H4A 0.5 9.29 0.35 2.35e-19 Intelligence (multi-trait analysis); BRCA cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg21138405 chr5:131827807 IRF1 0.39 12.9 0.45 5.51e-34 Asthma (sex interaction); BRCA cis rs17345786 0.906 rs55710435 chr3:101180330 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.56 11.33 0.41 2.92e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs911186 0.786 rs13211901 chr6:27187612 G/A cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -8.63 -0.32 4.87e-17 Autism spectrum disorder or schizophrenia; BRCA cis rs597539 0.690 rs647661 chr11:68625875 T/C cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.71 15.81 0.53 9.4e-48 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1862618 0.853 rs33326 chr5:56142601 G/A cg22800045 chr5:56110881 MAP3K1 0.66 12.38 0.44 1.06e-31 Initial pursuit acceleration; BRCA cis rs826838 0.935 rs1843639 chr12:39178919 C/A cg13010199 chr12:38710504 ALG10B 0.54 11.47 0.41 8.32e-28 Heart rate; BRCA cis rs453301 0.686 rs1045527 chr8:8890041 A/G cg15556689 chr8:8085844 FLJ10661 -0.31 -8.24 -0.31 9.63e-16 Joint mobility (Beighton score); BRCA cis rs2576037 0.583 rs12386118 chr18:44540376 C/G cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.34 8.12 0.31 2.43e-15 Personality dimensions; BRCA cis rs1003719 0.788 rs2835602 chr21:38469069 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs7811142 0.830 rs11765869 chr7:99964789 T/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 18.21 0.58 5.13e-60 Platelet count; BRCA cis rs9341808 0.718 rs3812121 chr6:80968727 A/G cg08355045 chr6:80787529 NA 0.38 9.64 0.36 1.24e-20 Sitting height ratio; BRCA cis rs636291 0.500 rs655271 chr1:10536635 G/A cg17425144 chr1:10567563 PEX14 0.55 13.84 0.48 2.83e-38 Prostate cancer; BRCA cis rs11190604 1.000 rs11190602 chr10:102297256 T/C cg07080220 chr10:102295463 HIF1AN 0.63 14.95 0.51 1.42e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg20503657 chr10:835505 NA 1.04 18.24 0.59 3.93e-60 Eosinophil percentage of granulocytes; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg05863683 chr7:1912471 MAD1L1 0.44 9.45 0.35 6.29e-20 Bipolar disorder and schizophrenia; BRCA cis rs12530845 0.887 rs59400686 chr7:135360029 A/G cg23117316 chr7:135346802 PL-5283 -0.42 -9.58 -0.35 2.03e-20 Red blood cell traits; BRCA cis rs35417517 1 rs35417517 chr7:91772730 CG/C cg01689657 chr7:91764605 CYP51A1 0.22 8.11 0.31 2.58e-15 Breast cancer; BRCA cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg23711669 chr6:146136114 FBXO30 0.74 17.76 0.57 1.14e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs9325144 0.723 rs1586373 chr12:39181582 G/A cg26384229 chr12:38710491 ALG10B -0.51 -11.4 -0.41 1.61e-27 Morning vs. evening chronotype; BRCA cis rs11112613 0.713 rs68053161 chr12:105950035 G/C cg03607813 chr12:105948248 NA 0.6 11.21 0.41 9.41e-27 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs12760731 0.720 rs12022646 chr1:178355821 A/G cg00404053 chr1:178313656 RASAL2 0.62 8.06 0.3 3.74e-15 Obesity-related traits; BRCA cis rs2637266 0.935 rs2583057 chr10:78396019 C/T cg18941641 chr10:78392320 NA 0.36 8.31 0.31 5.79e-16 Pulmonary function; BRCA cis rs1153858 1.000 rs1346268 chr15:45673029 T/C cg21132104 chr15:45694354 SPATA5L1 0.75 16.9 0.56 2.9e-53 Homoarginine levels; BRCA trans rs2197308 0.715 rs11181816 chr12:37911626 A/G cg06521331 chr12:34319734 NA 0.45 8.91 0.33 5.31e-18 Morning vs. evening chronotype; BRCA cis rs4285028 0.747 rs1574133 chr3:121468794 G/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.85 -0.48 2.56e-38 Multiple sclerosis; BRCA cis rs365132 1.000 rs2292255 chr5:176334195 C/T cg16309518 chr5:176445507 NA -0.51 -13.26 -0.46 1.3e-35 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs3771570 0.901 rs869943 chr2:242431585 C/G cg21155796 chr2:242212141 HDLBP 0.63 9.7 0.36 7.62e-21 Prostate cancer; BRCA cis rs1862618 0.853 rs832568 chr5:56153776 G/A cg22800045 chr5:56110881 MAP3K1 0.66 12.28 0.44 2.9e-31 Initial pursuit acceleration; BRCA cis rs12477438 0.520 rs6743355 chr2:99732360 C/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA cis rs7264396 0.790 rs6121015 chr20:34243017 C/T cg23207816 chr20:34252616 CPNE1;RBM12 0.41 8.62 0.32 5.45e-17 Total cholesterol levels; BRCA cis rs9309473 0.607 rs7604588 chr2:73571417 C/T cg20560298 chr2:73613845 ALMS1 -0.42 -11.27 -0.41 5.44e-27 Metabolite levels; BRCA cis rs10911232 0.507 rs3934578 chr1:183027216 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.25e-51 Hypertriglyceridemia; BRCA cis rs10949834 0.504 rs77541100 chr7:73555605 C/T cg07137043 chr7:73588983 EIF4H -0.62 -9.42 -0.35 7.84e-20 Verbal memory performance (residualized delayed recall change); BRCA cis rs62064224 0.589 rs9910731 chr17:30784034 A/G cg18200150 chr17:30822561 MYO1D 0.36 9.08 0.34 1.37e-18 Schizophrenia; BRCA cis rs62244186 0.593 rs9814298 chr3:44871899 T/A cg02073558 chr3:44770973 ZNF501 0.38 8.0 0.3 5.75e-15 Depressive symptoms; BRCA cis rs736408 0.527 rs2336147 chr3:52626443 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.39 -9.63 -0.36 1.35e-20 Bipolar disorder; BRCA cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg02297831 chr4:17616191 MED28 -0.35 -8.02 -0.3 5.22e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7267979 1.000 rs2257982 chr20:25269630 A/G cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6951245 1.000 rs74366004 chr7:1088630 A/C cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.52 -0.52 2.52e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7552404 0.727 rs1159214 chr1:76317910 G/T cg22875332 chr1:76189707 ACADM -0.51 -9.8 -0.36 3.14e-21 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7811142 1.000 rs68116612 chr7:100006493 G/A cg00814883 chr7:100076585 TSC22D4 -0.51 -11.66 -0.42 1.24e-28 Platelet count; BRCA cis rs1790761 0.520 rs12805884 chr11:67387977 G/A cg24690094 chr11:67383802 NA -0.54 -11.46 -0.41 8.69e-28 Mean corpuscular volume; BRCA cis rs3125734 0.633 rs10761616 chr10:64009076 G/A cg19640130 chr10:64028056 RTKN2 -0.34 -9.7 -0.36 7.4e-21 Rheumatoid arthritis; BRCA cis rs875971 0.522 rs7784623 chr7:65395034 T/G cg11764359 chr7:65958608 NA 0.61 13.42 0.47 2.37e-36 Aortic root size; BRCA cis rs10267417 0.603 rs10263094 chr7:19872801 C/T cg07541023 chr7:19748670 TWISTNB 0.49 8.72 0.33 2.42e-17 Night sleep phenotypes; BRCA cis rs798554 0.757 rs1182181 chr7:2873247 C/G cg23285459 chr7:2802560 GNA12 -0.36 -9.08 -0.34 1.29e-18 Height; BRCA cis rs2625529 0.824 rs2415130 chr15:72242554 G/A cg16672083 chr15:72433130 SENP8 -0.77 -16.36 -0.54 1.71e-50 Red blood cell count; BRCA cis rs1190552 0.846 rs3742437 chr14:102965047 G/A cg18135206 chr14:102964638 TECPR2 0.46 9.02 0.34 2.1e-18 Blood protein levels; BRCA cis rs12971120 0.947 rs4891559 chr18:72170397 C/T cg27029518 chr18:72166324 CNDP2 -0.31 -8.85 -0.33 8.44e-18 Refractive error; BRCA cis rs2712184 0.935 rs2541387 chr2:217666174 A/C cg05032264 chr2:217675019 NA -0.43 -10.63 -0.39 2.04e-24 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs2046867 0.818 rs17010195 chr3:72872852 A/G cg25664220 chr3:72788482 NA 0.43 9.79 0.36 3.37e-21 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs9814567 0.806 rs9857995 chr3:134316706 C/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.54 17.02 0.56 7.12e-54 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs933688 1.000 rs6869717 chr5:90694797 G/A cg26981201 chr5:90679533 LOC100129716;ARRDC3 0.76 15.63 0.53 7.54e-47 Smoking behavior; BRCA cis rs10056811 0.527 rs55798253 chr5:74380957 A/G cg19683494 chr5:74908142 NA 0.56 8.33 0.31 4.84e-16 Coronary artery disease; BRCA trans rs7618501 1.000 rs7374277 chr3:49784777 T/C cg21659725 chr3:3221576 CRBN -0.71 -21.67 -0.65 1.76e-78 Intelligence (multi-trait analysis); BRCA trans rs4332037 0.851 rs1403175 chr7:1964357 A/T cg25206134 chr2:45395956 NA -0.48 -8.23 -0.31 1.08e-15 Bipolar disorder; BRCA cis rs897984 0.762 rs1870293 chr16:30970941 T/C cg02466173 chr16:30829666 NA 0.47 10.47 0.38 9.03e-24 Dementia with Lewy bodies; BRCA cis rs2836974 0.897 rs2836924 chr21:40525639 C/T cg11890956 chr21:40555474 PSMG1 1.06 31.69 0.78 3.73e-133 Cognitive function; BRCA trans rs6089829 0.855 rs6090203 chr20:61663632 G/A cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.545 rs7810213 chr7:65946579 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.55 10.11 0.37 2.24e-22 Aortic root size; BRCA cis rs2153535 0.580 rs9379222 chr6:8514788 T/C cg07606381 chr6:8435919 SLC35B3 0.65 14.53 0.5 1.53e-41 Motion sickness; BRCA cis rs6835098 1.000 rs4561909 chr4:174086937 A/T cg27433088 chr4:174089019 GALNT7 0.34 9.06 0.34 1.6e-18 Dementia and core Alzheimer's disease neuropathologic changes; BRCA trans rs11039798 0.528 rs10839208 chr11:49030456 C/T cg03929089 chr4:120376271 NA 0.55 9.26 0.34 2.97e-19 Axial length; BRCA cis rs9612 0.718 rs346535 chr19:44251425 C/T cg08581076 chr19:44259116 C19orf61 0.43 7.85 0.3 1.72e-14 Exhaled nitric oxide output; BRCA cis rs7582180 0.764 rs1967341 chr2:100924559 T/C cg14675211 chr2:100938903 LONRF2 0.49 11.2 0.4 1.07e-26 Intelligence (multi-trait analysis); BRCA cis rs1577917 0.740 rs9353327 chr6:86394066 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -13.27 -0.46 1.12e-35 Response to antipsychotic treatment; BRCA cis rs7085104 0.632 rs7097872 chr10:104606636 C/T cg04362960 chr10:104952993 NT5C2 0.39 9.31 0.35 2.03e-19 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs910316 0.737 rs175072 chr14:75502827 T/C cg23033748 chr14:75592666 NEK9 -0.37 -8.82 -0.33 1.11e-17 Height; BRCA cis rs11958404 0.932 rs72816543 chr5:157416464 A/G cg05962755 chr5:157440814 NA 0.54 9.96 0.37 8.27e-22 IgG glycosylation; BRCA cis rs9287719 0.967 rs6759740 chr2:10747271 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.06 -0.3 3.74e-15 Prostate cancer; BRCA cis rs2153535 0.601 rs9505473 chr6:8538777 T/C cg07606381 chr6:8435919 SLC35B3 0.64 13.99 0.48 5.5e-39 Motion sickness; BRCA cis rs933688 0.938 rs1477348 chr5:90707823 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.87 18.8 0.6 4.37e-63 Smoking behavior; BRCA cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg12863693 chr15:85201151 NMB 0.45 8.19 0.31 1.44e-15 Schizophrenia; BRCA cis rs9467773 1.000 rs9467774 chr6:26505036 C/A cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.21e-20 Intelligence (multi-trait analysis); BRCA cis rs2842992 0.915 rs2758350 chr6:160118056 A/G cg19482086 chr6:160211437 TCP1;MRPL18 0.65 16.52 0.55 2.63e-51 Age-related macular degeneration (geographic atrophy); BRCA cis rs6598955 0.617 rs11247883 chr1:26576247 T/G cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs7586879 0.616 rs6545813 chr2:25131287 C/T cg04586622 chr2:25135609 ADCY3 0.46 11.66 0.42 1.28e-28 Body mass index; BRCA cis rs9649213 0.574 rs9648908 chr7:97945236 C/T cg21770322 chr7:97807741 LMTK2 0.41 11.03 0.4 5.14e-26 Prostate cancer (SNP x SNP interaction); BRCA cis rs10461617 0.617 rs79742142 chr5:56104377 A/G cg12311346 chr5:56204834 C5orf35 -0.77 -14.92 -0.51 2.1e-43 Type 2 diabetes; BRCA cis rs7809950 0.678 rs2107317 chr7:106899685 T/C cg23024343 chr7:107201750 COG5 -0.44 -8.69 -0.33 2.96e-17 Coronary artery disease; BRCA cis rs7666738 0.800 rs7684523 chr4:98983175 G/T cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.851 rs10470258 chr21:46658989 C/T cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs35306767 0.855 rs11253465 chr10:897208 A/C cg20503657 chr10:835505 NA 0.99 17.46 0.57 4.23e-56 Eosinophil percentage of granulocytes; BRCA cis rs9486719 0.895 rs3734239 chr6:96996244 A/G cg06623918 chr6:96969491 KIAA0776 -0.78 -14.03 -0.49 3.69e-39 Migraine;Coronary artery disease; BRCA trans rs7980799 0.649 rs1994135 chr12:33682405 T/C cg26384229 chr12:38710491 ALG10B 0.39 8.74 0.33 2.02e-17 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6951245 1.000 rs78523927 chr7:1089458 T/C cg04025307 chr7:1156635 C7orf50 0.59 9.37 0.35 1.26e-19 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs2727020 0.521 rs1909220 chr11:49572109 T/C cg11707556 chr5:10655725 ANKRD33B -0.42 -9.36 -0.35 1.39e-19 Coronary artery disease; BRCA cis rs6121246 0.559 rs6058468 chr20:30406448 C/A cg13852791 chr20:30311386 BCL2L1 0.96 23.2 0.68 7.58e-87 Mean corpuscular hemoglobin; BRCA cis rs3008870 1.000 rs2815352 chr1:67482104 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.95 21.16 0.64 9.69e-76 Lymphocyte percentage of white cells; BRCA cis rs6878727 0.665 rs2633536 chr5:123667422 A/T cg01806427 chr5:123737813 NA -0.37 -8.27 -0.31 7.92e-16 Breast cancer; BRCA cis rs6912958 0.781 rs4464759 chr6:88282621 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.52 -0.32 1.11e-16 Monocyte percentage of white cells; BRCA cis rs2836950 0.520 rs11911087 chr21:40665192 G/A cg11644478 chr21:40555479 PSMG1 -0.49 -10.49 -0.38 7.48e-24 Menarche (age at onset); BRCA cis rs4664304 0.620 rs2136977 chr2:160722850 C/T cg14819504 chr2:160761413 LY75 0.34 8.51 0.32 1.22e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs12950390 0.853 rs12450733 chr17:45855404 A/G cg24803719 chr17:45855879 NA -0.31 -8.32 -0.31 5.38e-16 IgG glycosylation; BRCA cis rs8062405 1.000 rs3088215 chr16:28853996 A/C cg09754948 chr16:28834200 ATXN2L 0.45 8.9 0.33 5.77e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs1707322 1.000 rs1768818 chr1:46514286 G/C cg03146154 chr1:46216737 IPP -0.44 -9.78 -0.36 3.68e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4595586 0.545 rs7967295 chr12:39376866 G/A cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs7618915 0.570 rs2336145 chr3:52629750 A/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.35 -7.87 -0.3 1.57e-14 Bipolar disorder; BRCA cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.72 0.36 6.4e-21 Bipolar disorder; BRCA cis rs10992471 0.528 rs7031567 chr9:95241363 A/G cg14631576 chr9:95140430 CENPP -0.34 -8.51 -0.32 1.27e-16 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7147624 1.000 rs7147624 chr14:65865625 G/T cg03016385 chr14:66212404 NA 0.52 8.02 0.3 5.04e-15 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1552244 0.816 rs13059144 chr3:10010197 A/C cg00149659 chr3:10157352 C3orf10 0.69 12.27 0.44 3.05e-31 Alzheimer's disease; BRCA cis rs35110281 0.811 rs9980185 chr21:45057905 A/G cg01579765 chr21:45077557 HSF2BP -0.41 -11.04 -0.4 4.72e-26 Mean corpuscular volume; BRCA cis rs7312933 0.865 rs1920687 chr12:42398275 T/C cg17420585 chr12:42539391 GXYLT1 -0.48 -10.31 -0.38 3.67e-23 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2836974 0.931 rs2836972 chr21:40652142 G/A cg17971929 chr21:40555470 PSMG1 0.78 18.39 0.59 6.48e-61 Cognitive function; BRCA cis rs7474896 0.559 rs10740949 chr10:37978435 A/G cg25427524 chr10:38739819 LOC399744 -0.54 -9.97 -0.37 7.53e-22 Obesity (extreme); BRCA cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg24642439 chr20:33292090 TP53INP2 -0.55 -11.84 -0.42 2.31e-29 Glomerular filtration rate (creatinine); BRCA cis rs7086627 0.515 rs11202963 chr10:82210392 A/G cg00277334 chr10:82204260 NA -0.85 -25.02 -0.7 7.78e-97 Post bronchodilator FEV1; BRCA cis rs2953145 0.568 rs2975752 chr2:241521327 A/G cg07929629 chr2:241523174 NA 0.49 10.32 0.38 3.36e-23 Bipolar disorder; BRCA cis rs312274 0.550 rs11178856 chr12:41267456 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -9.01 -0.34 2.39e-18 Metabolite levels (X-11787); BRCA cis rs34779708 0.931 rs11010082 chr10:35351155 A/G cg03585969 chr10:35415529 CREM 0.45 9.44 0.35 6.86e-20 Inflammatory bowel disease;Crohn's disease; BRCA cis rs72781680 1.000 rs6731001 chr2:24192952 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.05 0.34 1.68e-18 Lymphocyte counts; BRCA cis rs10504229 0.906 rs67389108 chr8:58193718 G/A cg05313129 chr8:58192883 C8orf71 -0.45 -9.39 -0.35 1.06e-19 Developmental language disorder (linguistic errors); BRCA cis rs1635 0.655 rs1416919 chr6:28302884 T/G cg15743358 chr6:28303923 ZNF323 -0.75 -8.56 -0.32 8.52e-17 Schizophrenia; BRCA cis rs10504229 0.683 rs67077711 chr8:58139769 G/T cg20607798 chr8:58055168 NA 0.47 8.29 0.31 6.44e-16 Developmental language disorder (linguistic errors); BRCA cis rs12477438 0.501 rs7608938 chr2:99782226 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA cis rs911555 0.755 rs1116095 chr14:103931879 A/G cg24130564 chr14:104152367 KLC1 0.35 7.96 0.3 8.02e-15 Intelligence (multi-trait analysis); BRCA cis rs11112613 0.713 rs73184082 chr12:105951748 T/C cg03607813 chr12:105948248 NA 0.55 10.39 0.38 1.81e-23 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs6963495 0.818 rs56268110 chr7:105166712 T/C cg19920283 chr7:105172520 RINT1 0.59 9.39 0.35 1.03e-19 Bipolar disorder (body mass index interaction); BRCA cis rs778371 0.578 rs2675956 chr2:233753340 G/A cg25237894 chr2:233734115 C2orf82 -0.31 -8.78 -0.33 1.49e-17 Schizophrenia; BRCA cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg26373071 chr5:1325741 CLPTM1L 0.49 12.16 0.43 9.58e-31 Lung cancer; BRCA cis rs12477438 0.765 rs72957180 chr2:99694452 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.83 -0.58 5.25e-58 Chronic sinus infection; BRCA cis rs701145 0.585 rs365119 chr3:153916502 A/T cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs4319547 0.619 rs10744208 chr12:122931559 C/A cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.71 -0.36 7.18e-21 Body mass index; BRCA cis rs12368653 0.616 rs1027315 chr12:58034192 T/C cg12615879 chr12:58013172 SLC26A10 0.32 9.05 0.34 1.66e-18 Multiple sclerosis; BRCA cis rs9790314 0.875 rs459515 chr3:161092351 T/C cg04691961 chr3:161091175 C3orf57 -0.58 -15.0 -0.51 8.21e-44 Morning vs. evening chronotype; BRCA cis rs9291683 0.935 rs1860910 chr4:10275470 T/G cg00071950 chr4:10020882 SLC2A9 0.45 10.93 0.4 1.26e-25 Bone mineral density; BRCA cis rs9467773 0.620 rs2494701 chr6:26634432 C/T cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.27e-42 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.781 rs3816311 chr13:44453783 G/A cg17145862 chr1:211918768 LPGAT1 0.66 16.49 0.55 3.56e-51 Leprosy; BRCA cis rs7772486 0.817 rs9322047 chr6:146400394 G/A cg05347473 chr6:146136440 FBXO30 0.4 8.03 0.3 4.71e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 0.699 rs6599205 chr3:38529440 C/G cg24069376 chr3:38537580 EXOG 0.31 8.72 0.33 2.4e-17 Electrocardiographic conduction measures; BRCA cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.51 11.18 0.4 1.23e-26 Personality dimensions; BRCA cis rs765787 0.530 rs2668751 chr15:45517293 T/C cg24006582 chr15:45444508 DUOX1 -0.55 -11.28 -0.41 4.73e-27 Uric acid levels; BRCA cis rs4588572 0.643 rs10068686 chr5:77795220 C/T cg11547950 chr5:77652471 NA -0.5 -9.14 -0.34 7.95e-19 Triglycerides; BRCA cis rs977987 0.585 rs62059845 chr16:75430713 A/G cg03315344 chr16:75512273 CHST6 0.52 12.24 0.44 4.23e-31 Dupuytren's disease; BRCA cis rs7772486 0.727 rs12190966 chr6:146146820 T/G cg05347473 chr6:146136440 FBXO30 0.38 7.83 0.3 1.97e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs8028182 0.636 rs62027181 chr15:75839952 A/G cg20655648 chr15:75932815 IMP3 0.44 8.65 0.32 4.14e-17 Sudden cardiac arrest; BRCA cis rs897984 0.609 rs55979739 chr16:31049155 A/G cg02466173 chr16:30829666 NA -0.44 -9.85 -0.36 2.08e-21 Dementia with Lewy bodies; BRCA cis rs9467773 0.620 rs2451711 chr6:26663110 A/G cg11502198 chr6:26597334 ABT1 0.56 12.01 0.43 4.06e-30 Intelligence (multi-trait analysis); BRCA cis rs10193935 1.000 rs13386385 chr2:42436928 G/T cg27598129 chr2:42591480 NA -0.97 -15.28 -0.52 3.74e-45 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.752 rs28438704 chr1:46170544 G/A cg06784218 chr1:46089804 CCDC17 0.51 12.22 0.44 5.44e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3099143 1.000 rs3106378 chr15:77110524 A/C cg21673338 chr15:77095150 SCAPER -0.54 -9.33 -0.35 1.67e-19 Recalcitrant atopic dermatitis; BRCA trans rs9409565 0.513 rs16912862 chr9:97050005 A/G cg05679027 chr9:99775184 HIATL2 -0.36 -8.38 -0.31 3.47e-16 Colorectal cancer (alcohol consumption interaction); BRCA cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg08917208 chr2:24149416 ATAD2B 0.94 14.13 0.49 1.25e-39 Lymphocyte counts; BRCA cis rs11608355 0.515 rs12822282 chr12:109923207 G/A cg05360138 chr12:110035743 NA 0.74 13.54 0.47 6.41e-37 Neuroticism; BRCA cis rs17604090 0.793 rs73687726 chr7:29688773 T/C cg19413766 chr7:29689036 LOC646762 -0.51 -8.2 -0.31 1.33e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs7777484 0.500 rs757787 chr7:2836355 G/A cg19717773 chr7:2847554 GNA12 -0.5 -11.84 -0.42 2.24e-29 Height; BRCA cis rs9811920 0.609 rs7636447 chr3:99612677 G/C cg07805332 chr3:99536008 MIR548G;C3orf26 -0.36 -8.24 -0.31 9.74e-16 Axial length; BRCA cis rs72781680 1.000 rs72781649 chr2:24210864 A/G cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 8.02e-19 Lymphocyte counts; BRCA cis rs17253792 0.822 rs28392709 chr14:56093685 G/A cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs7131987 0.903 rs2194518 chr12:29419460 C/T cg09582351 chr12:29534625 ERGIC2 -0.51 -11.73 -0.42 6.21e-29 QT interval; BRCA cis rs3784262 0.631 rs4646566 chr15:58348173 G/A cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.75 -0.36 4.82e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7412746 0.658 rs6669855 chr1:150861229 C/T cg18016565 chr1:150552671 MCL1 0.36 8.09 0.3 3.07e-15 Melanoma; BRCA cis rs7635838 0.619 rs347616 chr3:11277927 G/A cg00170343 chr3:11313890 ATG7 0.44 8.42 0.32 2.43e-16 HDL cholesterol; BRCA cis rs11098499 0.710 rs4145952 chr4:120155806 C/A cg09307838 chr4:120376055 NA 0.55 11.39 0.41 1.64e-27 Corneal astigmatism; BRCA cis rs9300255 0.543 rs1617156 chr12:123590165 T/C cg00376283 chr12:123451042 ABCB9 0.51 11.48 0.41 7.05e-28 Neutrophil percentage of white cells; BRCA cis rs977987 0.778 rs8057849 chr16:75443816 T/C cg03315344 chr16:75512273 CHST6 0.53 12.52 0.44 2.66e-32 Dupuytren's disease; BRCA cis rs67478160 0.506 rs6575998 chr14:104250417 A/G cg26031613 chr14:104095156 KLC1 -0.5 -10.09 -0.37 2.69e-22 Schizophrenia; BRCA trans rs9325144 0.647 rs4616077 chr12:39092364 T/C cg23762105 chr12:34175262 ALG10 0.35 7.86 0.3 1.69e-14 Morning vs. evening chronotype; BRCA cis rs2050392 0.767 rs10763787 chr10:30700753 G/A cg18806716 chr10:30721971 MAP3K8 0.58 13.42 0.47 2.25e-36 Inflammatory bowel disease; BRCA cis rs35110281 0.693 rs2838345 chr21:45092715 C/T cg21573476 chr21:45109991 RRP1B -0.41 -11.19 -0.4 1.11e-26 Mean corpuscular volume; BRCA cis rs2836974 0.568 rs429955 chr21:40539760 G/A cg11644478 chr21:40555479 PSMG1 0.67 15.32 0.52 2.27e-45 Cognitive function; BRCA cis rs10751667 0.666 rs7105477 chr11:964271 C/G cg10932868 chr11:921992 NA 0.48 12.49 0.44 3.31e-32 Alzheimer's disease (late onset); BRCA cis rs7412746 0.658 rs17660092 chr1:150797748 T/C cg18016565 chr1:150552671 MCL1 0.35 8.06 0.3 3.74e-15 Melanoma; BRCA cis rs9814567 1.000 rs4423809 chr3:134300107 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.38 8.69 0.33 2.92e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6582630 0.555 rs11181053 chr12:38271364 T/C cg26384229 chr12:38710491 ALG10B -0.4 -9.38 -0.35 1.15e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs473651 0.935 rs477041 chr2:239355995 C/G cg18131467 chr2:239335373 ASB1 -0.94 -33.3 -0.8 8.82e-142 Multiple system atrophy; BRCA trans rs11098499 0.618 rs35265692 chr4:120325135 T/C cg25214090 chr10:38739885 LOC399744 0.53 12.04 0.43 2.97e-30 Corneal astigmatism; BRCA cis rs10504229 0.683 rs2291765 chr8:58142874 C/T cg24829409 chr8:58192753 C8orf71 -0.42 -8.36 -0.31 3.89e-16 Developmental language disorder (linguistic errors); BRCA cis rs739401 0.572 rs404629 chr11:3077025 A/G cg05729581 chr11:3078854 CARS -0.34 -8.06 -0.3 3.78e-15 Longevity; BRCA cis rs6952808 0.531 rs1107351 chr7:2177093 G/A cg03354898 chr7:1950403 MAD1L1 -0.45 -8.62 -0.32 5.1e-17 Bipolar disorder and schizophrenia; BRCA cis rs694739 0.541 rs61886926 chr11:64133552 C/T cg02228329 chr11:64053129 BAD;GPR137 0.54 11.88 0.43 1.45e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs12618769 0.597 rs17446058 chr2:99164160 A/G cg10123293 chr2:99228465 UNC50 0.41 8.02 0.3 4.94e-15 Bipolar disorder; BRCA cis rs4727027 0.933 rs1468369 chr7:148839840 G/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.38 8.71 0.33 2.58e-17 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6570726 0.557 rs403956 chr6:145829956 T/C cg23711669 chr6:146136114 FBXO30 0.72 14.71 0.5 2.22e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs801193 0.967 rs3800823 chr7:66147110 C/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.18 -0.31 1.53e-15 Aortic root size; BRCA cis rs1008375 0.931 rs1860592 chr4:17577028 C/G cg04450456 chr4:17643702 FAM184B 0.42 12.5 0.44 3.05e-32 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs3784262 0.512 rs4646571 chr15:58343137 T/C cg12031962 chr15:58353849 ALDH1A2 -0.5 -12.36 -0.44 1.22e-31 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11229555 0.645 rs11229462 chr11:58209931 A/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg18230493 chr5:56204884 C5orf35 0.61 12.87 0.45 7.3e-34 Initial pursuit acceleration; BRCA cis rs7772486 0.875 rs1331645 chr6:146398407 C/G cg23711669 chr6:146136114 FBXO30 0.74 17.38 0.57 1.13e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs17253792 0.822 rs13379342 chr14:56050452 A/G cg01858014 chr14:56050164 KTN1 -0.77 -11.27 -0.41 5.52e-27 Putamen volume; BRCA cis rs17253792 0.822 rs17253723 chr14:56154015 A/G cg01858014 chr14:56050164 KTN1 -0.76 -9.53 -0.35 3.34e-20 Putamen volume; BRCA cis rs6912958 1.000 rs6454630 chr6:88171357 C/G cg08069147 chr6:88032118 GJB7;C6orf162 0.44 9.24 0.34 3.51e-19 Monocyte percentage of white cells; BRCA cis rs60843830 1.000 rs3828165 chr2:220889 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.81 18.43 0.59 3.97e-61 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7020830 0.898 rs495863 chr9:37346955 T/C cg14294708 chr9:37120828 ZCCHC7 1.07 32.6 0.79 4.74e-138 Schizophrenia; BRCA cis rs2153535 0.580 rs1832100 chr6:8446956 G/A cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs10504229 0.683 rs11774585 chr8:58132685 G/A cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs6570726 0.791 rs378937 chr6:145834745 C/T cg13319975 chr6:146136371 FBXO30 -0.42 -9.68 -0.36 8.78e-21 Lobe attachment (rater-scored or self-reported); BRCA cis rs13102973 0.864 rs7697346 chr4:135899283 G/A cg14419869 chr4:135874104 NA 0.47 9.5 0.35 4.18e-20 Subjective well-being; BRCA cis rs7523273 0.606 rs1962149 chr1:207956559 G/A cg22525895 chr1:207977042 MIR29B2 -0.54 -13.47 -0.47 1.38e-36 Schizophrenia; BRCA cis rs244731 1.000 rs244731 chr5:176539679 C/T cg16006841 chr5:176797999 RGS14 0.69 11.18 0.4 1.2e-26 Urate levels in lean individuals; BRCA cis rs801193 1.000 rs2420824 chr7:66131116 G/A cg11764359 chr7:65958608 NA -0.63 -14.06 -0.49 2.65e-39 Aortic root size; BRCA cis rs3780378 0.967 rs7852988 chr9:5010751 C/A cg02405213 chr9:5042618 JAK2 -0.44 -8.94 -0.33 4.08e-18 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs9304742 0.854 rs11084211 chr19:53460861 C/T cg09915433 chr19:53449742 NA -0.71 -15.73 -0.53 2.29e-47 Psoriasis; BRCA cis rs4689592 0.513 rs3857178 chr4:7066516 G/A cg02503808 chr4:7069936 GRPEL1 0.8 18.41 0.59 4.58e-61 Monocyte percentage of white cells; BRCA cis rs6964587 1.000 rs733957 chr7:91707197 C/T cg17063962 chr7:91808500 NA 0.52 12.4 0.44 8.5e-32 Breast cancer; BRCA cis rs17270561 0.887 rs12201170 chr6:25866247 A/G cg16482183 chr6:26056742 HIST1H1C 0.76 13.58 0.47 4.48e-37 Iron status biomarkers; BRCA cis rs9527 0.590 rs10883820 chr10:104764661 A/C cg04362960 chr10:104952993 NT5C2 -0.44 -10.04 -0.37 4.18e-22 Arsenic metabolism; BRCA cis rs7903847 0.642 rs11189191 chr10:99148796 T/C cg20016023 chr10:99160130 RRP12 -0.26 -7.82 -0.3 2.2e-14 Granulocyte percentage of myeloid white cells; BRCA cis rs36051895 0.658 rs10974910 chr9:5010091 G/A cg02405213 chr9:5042618 JAK2 -0.5 -9.01 -0.34 2.39e-18 Pediatric autoimmune diseases; BRCA cis rs9837602 1.000 rs793496 chr3:99507254 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.6 -10.9 -0.4 1.8e-25 Breast cancer; BRCA cis rs7561273 0.609 rs2160943 chr2:24288775 G/A cg04809136 chr2:24300158 SF3B14 -0.4 -9.28 -0.34 2.62e-19 Quantitative traits; BRCA cis rs12142240 0.698 rs6684274 chr1:46810842 A/G cg14993813 chr1:46806288 NSUN4 0.47 9.17 0.34 6.65e-19 Menopause (age at onset); BRCA cis rs4074536 0.536 rs10754348 chr1:116290564 C/G cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs2880765 0.743 rs7168345 chr15:86013601 A/G cg10818794 chr15:86012489 AKAP13 0.3 8.25 0.31 9.39e-16 Coronary artery disease; BRCA trans rs7246760 0.867 rs16981648 chr19:9804424 A/C cg02900749 chr2:68251473 NA -0.48 -7.84 -0.3 1.89e-14 Pursuit maintenance gain; BRCA cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg06582575 chr6:163149167 PACRG;PARK2 0.96 14.43 0.5 4.63e-41 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7575217 0.654 rs62155196 chr2:101701022 A/G cg23907051 chr2:101730305 TBC1D8 0.2 7.85 0.3 1.75e-14 Sum neutrophil eosinophil counts;Myeloid white cell count;Granulocyte count; BRCA cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg13736514 chr6:26305472 NA -0.36 -12.25 -0.44 3.73e-31 Educational attainment; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg03188948 chr7:1209495 NA 0.68 11.16 0.4 1.47e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7666738 0.830 rs116103936 chr4:98954531 T/C cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.621 rs2363285 chr7:1091644 C/T cg16145915 chr7:1198662 ZFAND2A -0.5 -12.64 -0.45 7.76e-33 Longevity;Endometriosis; BRCA cis rs2153535 0.601 rs2327054 chr6:8443130 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 7.92e-24 Motion sickness; BRCA cis rs2839186 0.709 rs2839176 chr21:47678173 A/G cg05896524 chr21:47604654 C21orf56 0.5 10.28 0.38 4.83e-23 Testicular germ cell tumor; BRCA cis rs2243480 1.000 rs427044 chr7:65508545 G/A cg18252515 chr7:66147081 NA -0.95 -13.46 -0.47 1.56e-36 Diabetic kidney disease; BRCA cis rs60871478 0.853 rs62432864 chr7:808405 T/G cg05535760 chr7:792225 HEATR2 0.68 11.89 0.43 1.41e-29 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.519 rs11732209 chr4:98801643 A/G cg05340658 chr4:99064831 C4orf37 0.55 10.7 0.39 1.07e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs17253792 0.731 rs74829671 chr14:56112759 G/C cg01858014 chr14:56050164 KTN1 -0.76 -10.55 -0.39 4.43e-24 Putamen volume; BRCA cis rs2742234 0.541 rs4648313 chr10:43716739 G/A cg15436174 chr10:43711423 RASGEF1A 0.53 10.6 0.39 2.8e-24 Hirschsprung disease; BRCA cis rs17270561 0.887 rs9358870 chr6:25719210 T/C cg16482183 chr6:26056742 HIST1H1C 0.59 10.27 0.38 5.25e-23 Iron status biomarkers; BRCA cis rs172166 0.611 rs203883 chr6:28078356 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.25 8.14 0.31 2.08e-15 Cardiac Troponin-T levels; BRCA cis rs2171564 0.791 rs9826586 chr3:112441312 C/T cg06685282 chr3:112453648 NA 0.34 8.02 0.3 5.07e-15 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs4566357 0.595 rs1320406 chr2:227920474 C/T cg11843606 chr2:227700838 RHBDD1 -0.43 -9.64 -0.36 1.31e-20 Coronary artery disease; BRCA cis rs9814567 0.896 rs2177602 chr3:134245866 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.66 -0.61 1.21e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2197308 0.715 rs11181816 chr12:37911626 A/G cg26384229 chr12:38710491 ALG10B -0.58 -13.44 -0.47 2e-36 Morning vs. evening chronotype; BRCA cis rs4555082 0.834 rs1473672 chr14:105721981 G/T cg10792982 chr14:105748885 BRF1 0.48 11.12 0.4 2.17e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs3806843 1.000 rs6891995 chr5:140172008 A/G cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.8 -0.36 3.32e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs2204008 0.902 rs11520218 chr12:38223227 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.08 0.37 2.81e-22 Bladder cancer; BRCA cis rs13082711 0.911 rs35262121 chr3:27508277 G/A cg02860705 chr3:27208620 NA 0.53 10.45 0.38 1.06e-23 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg19077165 chr18:44547161 KATNAL2 -0.54 -11.75 -0.42 5.56e-29 Personality dimensions; BRCA cis rs273218 1.000 rs273218 chr5:53380555 T/C ch.5.1024479R chr5:53302184 ARL15 0.44 8.9 0.33 5.71e-18 Migraine; BRCA trans rs11098499 0.909 rs7681978 chr4:120383775 T/C cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs11792861 0.926 rs10512391 chr9:111809530 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.42 7.91 0.3 1.11e-14 Menarche (age at onset); BRCA trans rs853679 0.882 rs3757188 chr6:28107357 T/C cg01620082 chr3:125678407 NA -0.57 -8.21 -0.31 1.21e-15 Depression; BRCA cis rs11252926 0.537 rs4881255 chr10:453638 T/C cg16386425 chr10:429943 DIP2C -0.41 -8.68 -0.32 3.18e-17 Psychosis in Alzheimer's disease; BRCA cis rs9462027 0.727 rs3798352 chr6:34734809 T/A cg07306190 chr6:34760872 UHRF1BP1 -0.27 -8.06 -0.3 3.7e-15 Systemic lupus erythematosus; BRCA cis rs1065852 0.526 rs9623490 chr22:42398266 G/C cg22189786 chr22:42395067 WBP2NL 0.43 8.67 0.32 3.67e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs9902453 0.726 rs3115092 chr17:28036350 C/T cg26525008 chr17:28256777 EFCAB5;SSH2 0.56 14.62 0.5 5.74e-42 Coffee consumption (cups per day); BRCA cis rs2075371 1.000 rs2598285 chr7:133971153 A/T cg20476274 chr7:133979776 SLC35B4 0.68 20.43 0.63 9.26e-72 Mean platelet volume; BRCA cis rs3762637 0.941 rs9837149 chr3:122230845 G/C cg24169773 chr3:122142474 KPNA1 -0.43 -8.03 -0.3 4.75e-15 LDL cholesterol levels; BRCA cis rs13064411 0.696 rs35860985 chr3:113209828 C/T cg18753928 chr3:113234510 CCDC52 -0.59 -12.52 -0.44 2.53e-32 Response to simvastatin treatment (PCSK9 protein level change); BRCA trans rs561341 0.941 rs72825736 chr17:30330286 G/A cg20587970 chr11:113659929 NA -1.24 -22.68 -0.67 5.38e-84 Hip circumference adjusted for BMI; BRCA trans rs1005277 0.579 rs116912400 chr10:38479207 G/T cg23533926 chr12:111358616 MYL2 -0.43 -8.97 -0.33 3.19e-18 Extrinsic epigenetic age acceleration; BRCA trans rs6089829 0.925 rs6122087 chr20:61664553 T/C cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA trans rs208520 0.690 rs12202401 chr6:66760544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 1.0 21.05 0.64 3.87e-75 Exhaled nitric oxide output; BRCA cis rs4665809 0.531 rs10199898 chr2:26445485 T/G cg22920501 chr2:26401640 FAM59B -0.91 -16.27 -0.54 4.46e-50 Gut microbiome composition (summer); BRCA cis rs425277 0.917 rs262656 chr1:2088754 A/C cg24578937 chr1:2090814 PRKCZ 0.59 18.6 0.59 5.12e-62 Height; BRCA cis rs11674184 0.714 rs9789525 chr2:11724580 G/T cg07314298 chr2:11723111 GREB1 -0.78 -19.38 -0.61 3.48e-66 Endometriosis; BRCA cis rs1008375 0.900 rs3822235 chr4:17694916 C/T cg04450456 chr4:17643702 FAM184B -0.29 -8.35 -0.31 4.4e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg18305652 chr10:134549665 INPP5A 0.49 11.09 0.4 2.96e-26 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs2777491 0.915 rs7178634 chr15:41634587 A/G cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.9 -0.48 1.47e-38 Ulcerative colitis; BRCA cis rs763121 0.853 rs138713 chr22:39142615 T/C cg06022373 chr22:39101656 GTPBP1 0.71 17.29 0.56 3.28e-55 Menopause (age at onset); BRCA cis rs7249142 0.549 rs7260127 chr19:19280499 C/T cg19540702 chr19:19281175 LOC729991-MEF2B;MEF2B 0.4 8.58 0.32 7.2e-17 IgG glycosylation; BRCA cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg08859206 chr1:53392774 SCP2 -0.49 -10.83 -0.39 3.38e-25 Monocyte count; BRCA cis rs7246657 0.722 rs2287229 chr19:38188652 G/A cg14683738 chr19:37701593 ZNF585B -0.47 -8.04 -0.3 4.29e-15 Coronary artery calcification; BRCA cis rs3793683 1.000 rs3793683 chr10:134568387 G/T cg27286337 chr10:134555280 INPP5A -0.84 -20.56 -0.63 1.82e-72 Migraine; BRCA trans rs2562456 0.876 rs2681370 chr19:21736838 T/C cg25042112 chr7:64838748 ZNF92 -0.45 -8.34 -0.31 4.45e-16 Pain; BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg22920501 chr2:26401640 FAM59B -0.81 -13.18 -0.46 2.83e-35 Gut microbiome composition (summer); BRCA cis rs2576037 0.583 rs892586 chr18:44560429 C/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.33 -8.03 -0.3 4.68e-15 Personality dimensions; BRCA cis rs36052053 0.908 rs13203987 chr6:109585240 G/A cg12927641 chr6:109611667 NA -0.51 -7.84 -0.3 1.89e-14 Red cell distribution width; BRCA cis rs3806843 0.741 rs4912597 chr5:140106857 C/G cg11822812 chr5:140052017 DND1 -0.29 -7.84 -0.3 1.91e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg00149659 chr3:10157352 C3orf10 0.76 13.09 0.46 7.1e-35 Alzheimer's disease; BRCA cis rs9644630 0.841 rs3185 chr8:19328959 A/C cg01280390 chr8:19363452 CSGALNACT1 -0.34 -8.03 -0.3 4.54e-15 Oropharynx cancer; BRCA cis rs6754311 0.608 rs3739020 chr2:136602491 T/G cg25344623 chr2:136566232 LCT -0.35 -8.77 -0.33 1.55e-17 Mosquito bite size; BRCA trans rs3812049 0.737 rs1993878 chr5:127476971 C/A cg16011800 chr17:1958478 HIC1 -0.54 -8.82 -0.33 1.05e-17 Lymphocyte counts;Red cell distribution width; BRCA cis rs2836950 0.527 rs2836958 chr21:40623526 T/C cg22974920 chr21:40686053 BRWD1 -0.35 -8.07 -0.3 3.38e-15 Menarche (age at onset); BRCA cis rs10493773 1.000 rs10493774 chr1:86137963 A/G cg17807903 chr1:86174739 ZNHIT6 -0.47 -9.78 -0.36 3.85e-21 Urate levels in overweight individuals; BRCA cis rs12618769 0.597 rs72821930 chr2:99127525 C/T cg10123293 chr2:99228465 UNC50 0.42 8.37 0.31 3.7e-16 Bipolar disorder; BRCA cis rs35740288 0.571 rs11631009 chr15:86318653 G/A cg20737812 chr15:86336631 KLHL25 -0.39 -8.6 -0.32 6.38e-17 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA trans rs11227306 0.934 rs2303384 chr11:65640204 C/T cg17712092 chr4:129076599 LARP1B -0.38 -8.19 -0.31 1.42e-15 DNA methylation (variation); BRCA cis rs72781680 1.000 rs72798411 chr2:24184343 A/G cg06627628 chr2:24431161 ITSN2 -0.59 -7.81 -0.3 2.31e-14 Lymphocyte counts; BRCA trans rs208520 0.690 rs9345764 chr6:66820597 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.1 -0.64 2.17e-75 Exhaled nitric oxide output; BRCA cis rs17401966 0.838 rs11121551 chr1:10435170 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.85 0.48 2.48e-38 Hepatocellular carcinoma; BRCA trans rs17685 0.884 rs3823882 chr7:75631913 T/C cg19862616 chr7:65841803 NCRNA00174 -0.65 -17.59 -0.57 8.92e-57 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7666738 0.830 rs28818218 chr4:98880575 A/C cg05340658 chr4:99064831 C4orf37 0.63 15.14 0.51 1.82e-44 Colonoscopy-negative controls vs population controls; BRCA trans rs7726839 0.561 rs56410216 chr5:583216 C/A cg25482853 chr8:67687455 SGK3 0.79 13.2 0.46 2.48e-35 Obesity-related traits; BRCA cis rs910316 1.000 rs175442 chr14:75603564 T/C cg23033748 chr14:75592666 NEK9 -0.43 -10.61 -0.39 2.43e-24 Height; BRCA cis rs9858542 0.953 rs9853683 chr3:49512588 A/G cg03060546 chr3:49711283 APEH -0.53 -10.58 -0.39 3.33e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs9818758 0.607 rs34823813 chr3:49749976 G/A cg00383909 chr3:49044727 WDR6 0.88 12.66 0.45 5.95e-33 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs2032447 0.714 rs199725 chr6:25953684 A/G cg03264133 chr6:25882463 NA -0.49 -10.33 -0.38 3.15e-23 Intelligence (multi-trait analysis); BRCA cis rs1506636 0.539 rs17701547 chr7:123383461 A/G cg03229431 chr7:123269106 ASB15 -0.5 -8.27 -0.31 7.64e-16 Plateletcrit;Platelet count; BRCA cis rs6089584 0.854 rs6061985 chr20:60622362 T/C cg13770153 chr20:60521292 NA -0.42 -9.41 -0.35 8.91e-20 Body mass index; BRCA trans rs35110281 0.776 rs2838338 chr21:45075582 T/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.47 10.22 0.37 8.53e-23 Mean corpuscular volume; BRCA cis rs2404602 0.735 rs2461871 chr15:76822418 C/G cg23625390 chr15:77176239 SCAPER -0.46 -11.18 -0.4 1.2e-26 Blood metabolite levels; BRCA cis rs7267979 0.903 rs2474766 chr20:25246153 A/G cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.52 0.32 1.13e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13064411 0.696 rs7624994 chr3:113228009 T/C cg18753928 chr3:113234510 CCDC52 -0.58 -12.31 -0.44 2.2e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7592578 0.639 rs61709084 chr2:191287685 A/C cg10560079 chr2:191398806 TMEM194B -0.65 -11.98 -0.43 5.89e-30 Diastolic blood pressure; BRCA cis rs11711311 1.000 rs12632983 chr3:113481913 A/C cg15478005 chr3:113465772 ATP6V1A;NAA50 0.36 9.3 0.35 2.16e-19 IgG glycosylation; BRCA cis rs8062405 1.000 rs2008514 chr16:28825605 A/G cg09754948 chr16:28834200 ATXN2L -0.46 -9.23 -0.34 4.06e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7647973 0.710 rs7629322 chr3:49621994 C/T cg03060546 chr3:49711283 APEH 0.6 9.96 0.37 8.39e-22 Menarche (age at onset); BRCA cis rs654950 0.934 rs638859 chr1:42001444 A/G cg06885757 chr1:42089581 HIVEP3 0.27 9.31 0.35 2.06e-19 Airway imaging phenotypes; BRCA cis rs1552244 0.938 rs56274701 chr3:10167790 G/A cg16606324 chr3:10149918 C3orf24 0.53 10.45 0.38 1.04e-23 Alzheimer's disease; BRCA cis rs7927592 1.000 rs7927592 chr11:68369960 G/A cg20283391 chr11:68216788 NA -0.43 -8.67 -0.32 3.64e-17 Total body bone mineral density; BRCA cis rs8114671 0.562 rs6088640 chr20:33472509 C/T cg07148914 chr20:33460835 GGT7 0.37 8.47 0.32 1.75e-16 Height; BRCA cis rs67478160 0.619 rs12878682 chr14:104233627 G/C cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.23 -0.41 7.77e-27 Schizophrenia; BRCA trans rs11039798 0.588 rs10437592 chr11:48598859 G/T cg15704280 chr7:45808275 SEPT13 0.52 9.05 0.34 1.64e-18 Axial length; BRCA cis rs4727027 0.901 rs1534198 chr7:148772323 T/C cg23583168 chr7:148888333 NA -0.82 -18.75 -0.6 7.72e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6750047 0.625 rs336036 chr2:38261143 C/T cg07380506 chr2:38303506 CYP1B1 -0.4 -9.18 -0.34 5.84e-19 Cutaneous malignant melanoma;Melanoma; BRCA cis rs55692411 0.537 rs71326904 chr3:49991060 C/T cg05623727 chr3:50126028 RBM5 0.43 8.35 0.31 4.15e-16 Intelligence (multi-trait analysis); BRCA cis rs13108904 0.539 rs11247997 chr4:1361057 T/C cg01939980 chr4:1354348 KIAA1530 0.34 7.86 0.3 1.61e-14 Obesity-related traits; BRCA cis rs2439831 0.850 rs10438303 chr15:44016417 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.7 12.14 0.43 1.12e-30 Lung cancer in ever smokers; BRCA cis rs12586317 0.547 rs115019197 chr14:35503764 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.27 -0.38 5.49e-23 Psoriasis; BRCA cis rs9790314 1.000 rs336543 chr3:161061080 C/T cg03342759 chr3:160939853 NMD3 0.64 13.68 0.48 1.51e-37 Morning vs. evening chronotype; BRCA cis rs1883415 0.534 rs2817208 chr6:24481373 T/A cg20631270 chr6:24437470 GPLD1 0.4 8.23 0.31 1.04e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs4073582 0.595 rs2508657 chr11:66043898 G/A cg14036092 chr11:66035641 RAB1B 0.39 10.23 0.38 7.55e-23 Gout; BRCA cis rs2576037 0.562 rs13381557 chr18:44513371 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.51 -10.38 -0.38 1.97e-23 Personality dimensions; BRCA cis rs17270561 0.609 rs9358879 chr6:25742918 C/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs2652834 0.950 rs4774474 chr15:63405580 C/G cg05507819 chr15:63340323 TPM1 0.44 8.46 0.32 1.89e-16 HDL cholesterol; BRCA cis rs4711336 1.000 rs764752 chr6:33658066 G/C cg14003231 chr6:33640908 ITPR3 0.32 7.86 0.3 1.69e-14 Height; BRCA cis rs4665809 1.000 rs4665299 chr2:26256840 A/C cg04944784 chr2:26401820 FAM59B -0.86 -13.03 -0.46 1.41e-34 Gut microbiome composition (summer); BRCA cis rs13191362 1.000 rs13207671 chr6:162979056 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.52 8.64 0.32 4.42e-17 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs453301 0.686 rs2409120 chr8:8882571 G/C cg06636001 chr8:8085503 FLJ10661 -0.48 -10.1 -0.37 2.36e-22 Joint mobility (Beighton score); BRCA cis rs17253792 0.545 rs12883972 chr14:56018020 A/G cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs2153535 0.580 rs1335636 chr6:8465047 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs9815354 0.812 rs73079360 chr3:41888372 T/A cg03022575 chr3:42003672 ULK4 0.68 9.46 0.35 5.93e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs4268898 0.662 rs9917315 chr2:24431501 C/A cg08917208 chr2:24149416 ATAD2B 0.52 8.28 0.31 7.42e-16 Asthma; BRCA cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg25019033 chr10:957182 NA -0.41 -7.88 -0.3 1.37e-14 Eosinophil percentage of granulocytes; BRCA cis rs3733585 0.699 rs7686538 chr4:9948077 C/T cg11266682 chr4:10021025 SLC2A9 -0.41 -10.83 -0.39 3.3e-25 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1008375 0.966 rs11722132 chr4:17697217 T/C cg04450456 chr4:17643702 FAM184B 0.33 9.62 0.36 1.44e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2050392 0.517 rs602966 chr10:30755853 C/T cg18806716 chr10:30721971 MAP3K8 -0.42 -9.94 -0.37 9.6e-22 Inflammatory bowel disease; BRCA cis rs9463078 0.817 rs3799967 chr6:44798701 A/G cg25276700 chr6:44698697 NA -0.36 -8.34 -0.31 4.53e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs12579753 0.871 rs10862362 chr12:82199383 T/G cg07988820 chr12:82153109 PPFIA2 -0.5 -8.75 -0.33 1.96e-17 Resting heart rate; BRCA cis rs854765 0.647 rs854790 chr17:18028318 C/G cg04398451 chr17:18023971 MYO15A -0.84 -20.12 -0.62 4.05e-70 Total body bone mineral density; BRCA cis rs61931739 0.500 rs10844789 chr12:34202279 C/G cg06521331 chr12:34319734 NA -0.65 -11.93 -0.43 9.53e-30 Morning vs. evening chronotype; BRCA cis rs6912958 0.712 rs4587138 chr6:88356915 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.31 -0.31 5.8e-16 Monocyte percentage of white cells; BRCA cis rs8103278 0.507 rs4802276 chr19:46260748 T/C cg14061069 chr19:46274453 DMPK 0.64 18.05 0.58 3.55e-59 Coronary artery disease; BRCA cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg02659138 chr7:134003124 SLC35B4 0.32 10.02 0.37 4.85e-22 Mean platelet volume; BRCA cis rs1707322 1.000 rs9429186 chr1:46539687 C/T cg06784218 chr1:46089804 CCDC17 -0.44 -10.42 -0.38 1.32e-23 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.967 rs1881122 chr7:1040946 A/T cg16145915 chr7:1198662 ZFAND2A -0.42 -9.36 -0.35 1.3e-19 Longevity;Endometriosis; BRCA cis rs889312 0.500 rs33328 chr5:56143419 T/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.32 -0.31 5.17e-16 Breast cancer;Breast cancer (early onset); BRCA trans rs61931739 0.500 rs11053207 chr12:34459827 A/G cg26384229 chr12:38710491 ALG10B 0.58 13.18 0.46 3.06e-35 Morning vs. evening chronotype; BRCA cis rs6782228 0.675 rs9841987 chr3:128385142 G/T cg16766828 chr3:128327626 NA -0.43 -9.47 -0.35 5.35e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs7520050 0.966 rs12139630 chr1:46350935 A/G cg24296786 chr1:45957014 TESK2 0.43 9.78 0.36 3.7e-21 Red blood cell count;Reticulocyte count; BRCA cis rs2075371 0.933 rs2544182 chr7:133949793 C/T cg20476274 chr7:133979776 SLC35B4 0.6 16.64 0.55 6.38e-52 Mean platelet volume; BRCA cis rs3857067 0.804 rs6821438 chr4:95091911 A/G cg11021082 chr4:95130006 SMARCAD1 -0.4 -9.43 -0.35 7.73e-20 QT interval; BRCA cis rs13064411 0.518 rs7623919 chr3:113219160 A/G cg18753928 chr3:113234510 CCDC52 -0.41 -9.19 -0.34 5.49e-19 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs2011503 0.769 rs72999059 chr19:19378245 A/C cg15839431 chr19:19639596 YJEFN3 -0.39 -8.51 -0.32 1.22e-16 Bipolar disorder; BRCA trans rs11098499 0.645 rs78422072 chr4:120281042 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.59 0.42 2.45e-28 Corneal astigmatism; BRCA cis rs11190604 1.000 rs2295772 chr10:102265183 G/A cg07080220 chr10:102295463 HIF1AN 0.61 14.51 0.5 1.97e-41 Palmitoleic acid (16:1n-7) levels; BRCA cis rs2404602 1.000 rs12441433 chr15:76816015 G/A cg22467129 chr15:76604101 ETFA -0.39 -8.77 -0.33 1.57e-17 Blood metabolite levels; BRCA cis rs2637266 0.967 rs10400134 chr10:78365158 G/C cg18941641 chr10:78392320 NA 0.34 7.81 0.3 2.33e-14 Pulmonary function; BRCA cis rs7301826 0.627 rs34103763 chr12:131290149 G/A cg11011512 chr12:131303247 STX2 -0.45 -11.27 -0.41 5.43e-27 Plasma plasminogen activator levels; BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg03188948 chr7:1209495 NA 0.49 10.11 0.37 2.16e-22 Longevity;Endometriosis; BRCA cis rs12210905 0.688 rs75968505 chr6:27476996 T/C cg08851530 chr6:28072375 NA 0.81 8.01 0.3 5.53e-15 Hip circumference adjusted for BMI; BRCA cis rs9859260 0.744 rs539816 chr3:195784076 T/A cg03462622 chr3:195777018 TFRC -0.38 -8.63 -0.32 4.83e-17 Mean corpuscular volume; BRCA cis rs2425143 1.000 rs6060639 chr20:34438183 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.54 -0.32 9.92e-17 Blood protein levels; BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg09177884 chr7:1199841 ZFAND2A -0.45 -9.81 -0.36 2.87e-21 Longevity;Endometriosis; BRCA cis rs2576037 0.899 rs12955429 chr18:44585484 C/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.35 -8.86 -0.33 7.73e-18 Personality dimensions; BRCA cis rs13191362 1.000 rs34594856 chr6:163051845 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.62 10.14 0.37 1.72e-22 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2625529 0.617 rs2957365 chr15:72348106 C/T cg16672083 chr15:72433130 SENP8 0.67 16.04 0.54 6.33e-49 Red blood cell count; BRCA cis rs7715811 0.913 rs73749951 chr5:13762514 G/A cg07548982 chr5:13769939 DNAH5 -0.37 -7.99 -0.3 6.53e-15 Subclinical atherosclerosis traits (other); BRCA cis rs754466 0.580 rs2579177 chr10:79529245 C/T cg17075019 chr10:79541650 NA -0.77 -18.39 -0.59 6.09e-61 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs1973993 0.567 rs2800433 chr1:96998126 T/A cg10631902 chr5:14652156 NA 0.48 14.7 0.5 2.28e-42 Weight; BRCA cis rs72781680 0.898 rs72786288 chr2:24075416 G/T cg20701182 chr2:24300061 SF3B14 0.58 9.04 0.34 1.86e-18 Lymphocyte counts; BRCA cis rs514406 0.729 rs534070 chr1:53308858 T/G cg24675658 chr1:53192096 ZYG11B -0.68 -15.37 -0.52 1.3e-45 Monocyte count; BRCA cis rs7178424 0.846 rs13379492 chr15:62184636 T/A cg00456672 chr15:62358751 C2CD4A -0.41 -9.16 -0.34 6.87e-19 Height; BRCA cis rs6088813 0.883 rs2425061 chr20:33915571 A/G cg14752227 chr20:34000481 UQCC 0.4 8.42 0.32 2.46e-16 Height; BRCA cis rs73198271 0.740 rs10092720 chr8:8649117 A/C cg15556689 chr8:8085844 FLJ10661 -0.34 -8.37 -0.31 3.56e-16 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg22920501 chr2:26401640 FAM59B -0.63 -10.9 -0.4 1.73e-25 Gut microbiome composition (summer); BRCA cis rs72781680 0.752 rs72796138 chr2:23926233 C/T cg08917208 chr2:24149416 ATAD2B 1.05 14.21 0.49 5.24e-40 Lymphocyte counts; BRCA trans rs10242455 0.702 rs73403290 chr7:99157828 C/T cg09045935 chr12:6379348 NA 0.84 8.15 0.31 1.99e-15 Blood metabolite levels; BRCA cis rs4887140 0.717 rs9920840 chr15:74054462 A/G cg11789681 chr15:74046708 NA 0.53 7.95 0.3 8.69e-15 Glucose homeostasis traits; BRCA cis rs754466 0.580 rs11002293 chr10:79537965 C/T cg17075019 chr10:79541650 NA -0.83 -20.39 -0.63 1.53e-71 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs12517041 1.000 rs10054160 chr5:23297609 C/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs6582630 0.519 rs12582285 chr12:38298753 C/T cg13010199 chr12:38710504 ALG10B 0.51 10.44 0.38 1.14e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs1552244 0.510 rs13075308 chr3:10034925 G/C cg10729496 chr3:10149963 C3orf24 0.41 7.88 0.3 1.44e-14 Alzheimer's disease; BRCA cis rs10751667 0.666 rs10794347 chr11:939863 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.65 0.55 5.42e-52 Alzheimer's disease (late onset); BRCA cis rs10751667 0.643 rs11246348 chr11:939476 G/C ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.19e-47 Alzheimer's disease (late onset); BRCA cis rs2276314 0.857 rs6507158 chr18:33636066 A/C cg19628046 chr18:33552617 C18orf21 0.54 11.31 0.41 3.83e-27 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs6088813 1.000 rs6141548 chr20:33971085 A/G cg14752227 chr20:34000481 UQCC -0.41 -8.65 -0.32 4.09e-17 Height; BRCA cis rs6545883 0.655 rs11893880 chr2:61422019 C/T cg15711740 chr2:61764176 XPO1 -0.47 -11.73 -0.42 6.56e-29 Tuberculosis; BRCA cis rs2075371 0.829 rs10954442 chr7:134007587 A/G cg20476274 chr7:133979776 SLC35B4 -0.59 -14.81 -0.51 6.92e-43 Mean platelet volume; BRCA cis rs709400 0.633 rs10141433 chr14:103962559 A/G cg26031613 chr14:104095156 KLC1 0.75 16.54 0.55 2.08e-51 Body mass index; BRCA cis rs3733585 0.781 rs57250714 chr4:9984529 C/T cg00071950 chr4:10020882 SLC2A9 0.43 10.03 0.37 4.31e-22 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7592578 0.723 rs4371384 chr2:191430741 A/G cg10560079 chr2:191398806 TMEM194B 0.73 13.49 0.47 1.19e-36 Diastolic blood pressure; BRCA cis rs7927771 0.689 rs10734557 chr11:47380061 A/C cg20307385 chr11:47447363 PSMC3 0.41 8.67 0.32 3.6e-17 Subjective well-being; BRCA cis rs10870270 0.956 rs7904594 chr10:133734671 C/T cg17892150 chr10:133769511 PPP2R2D -0.73 -15.66 -0.53 4.96e-47 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs66887589 0.720 rs11724758 chr4:120239878 G/A cg09307838 chr4:120376055 NA 0.47 10.19 0.37 1.07e-22 Diastolic blood pressure; BRCA cis rs17270561 0.666 rs4711099 chr6:25741809 C/G cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs4727027 0.651 rs12704068 chr7:148856153 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.46 10.36 0.38 2.42e-23 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7904368 0.806 rs7899923 chr10:16857394 G/A cg23933602 chr10:16859644 RSU1 0.55 8.56 0.32 8.37e-17 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs7615952 0.641 rs66520539 chr3:125780374 G/A cg18479299 chr3:125709523 NA -0.53 -8.14 -0.31 2.03e-15 Blood pressure (smoking interaction); BRCA cis rs262150 1.000 rs262154 chr7:158773936 G/A cg26536863 chr7:158807979 LOC154822 0.36 8.17 0.31 1.61e-15 Facial morphology (factor 20); BRCA cis rs1129187 0.755 rs9471985 chr6:42941324 T/C cg10862848 chr6:42927986 GNMT -0.35 -14.56 -0.5 1.08e-41 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9914988 0.943 rs2242345 chr17:27185827 C/T cg20469991 chr17:27169893 C17orf63 0.41 8.26 0.31 8.57e-16 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA trans rs7618501 1.000 rs11130221 chr3:49819102 C/G cg21665057 chr3:196295764 WDR53;FBXO45 0.54 16.92 0.56 2.51e-53 Intelligence (multi-trait analysis); BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 0.65 13.31 0.47 7.49e-36 Lymphocyte counts; BRCA cis rs7412746 0.611 rs11803940 chr1:150685835 A/G cg17724175 chr1:150552817 MCL1 0.25 8.37 0.31 3.69e-16 Melanoma; BRCA cis rs1552244 1.000 rs113153120 chr3:10156398 G/A cg18598329 chr3:10140678 FANCD2;C3orf24 -0.66 -12.3 -0.44 2.46e-31 Alzheimer's disease; BRCA cis rs4268898 0.717 rs2543662 chr2:24443271 G/T cg06627628 chr2:24431161 ITSN2 0.7 13.66 0.48 1.79e-37 Asthma; BRCA cis rs1475911 0.744 rs12481958 chr21:43517269 A/G cg19766460 chr21:43528205 UMODL1;C21orf128 0.57 11.67 0.42 1.13e-28 IgG glycosylation; BRCA cis rs4077515 0.874 rs10781505 chr9:139271355 C/T cg14019695 chr9:139328340 INPP5E -0.3 -7.83 -0.3 2.04e-14 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs2836950 0.565 rs7276046 chr21:40581293 T/C cg06238570 chr21:40685208 BRWD1 -0.39 -8.03 -0.3 4.66e-15 Menarche (age at onset); BRCA cis rs877282 0.891 rs34652870 chr10:772218 T/C cg17470449 chr10:769945 NA 0.5 8.9 0.33 5.64e-18 Uric acid levels; BRCA cis rs523522 0.962 rs11065145 chr12:120947419 A/G cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.17e-27 High light scatter reticulocyte count; BRCA cis rs7618915 0.547 rs2336542 chr3:52710636 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.84 0.36 2.34e-21 Bipolar disorder; BRCA cis rs861020 1.000 rs622832 chr1:209974232 A/C cg05527609 chr1:210001259 C1orf107 0.61 13.17 0.46 3.38e-35 Orofacial clefts; BRCA cis rs7647973 1.000 rs9860055 chr3:49506900 C/T cg07636037 chr3:49044803 WDR6 -0.74 -16.07 -0.54 4.89e-49 Menarche (age at onset); BRCA cis rs10870270 1.000 rs7199 chr10:133769848 C/G cg08754478 chr10:133766260 PPP2R2D -0.68 -14.11 -0.49 1.44e-39 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs11051970 0.879 rs2728669 chr12:32590651 C/T cg24626660 chr12:32551988 NA 0.3 8.48 0.32 1.52e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10504229 0.953 rs72650891 chr8:58179697 T/G cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs478304 0.903 rs61895677 chr11:65549415 T/C cg08755490 chr11:65554678 OVOL1 0.54 11.17 0.4 1.34e-26 Acne (severe); BRCA cis rs9818758 0.607 rs35108630 chr3:49088356 T/A cg00383909 chr3:49044727 WDR6 0.98 15.72 0.53 2.59e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs921968 0.541 rs562510 chr2:219443001 A/C cg02176678 chr2:219576539 TTLL4 0.46 12.16 0.43 9.47e-31 Mean corpuscular hemoglobin concentration; BRCA trans rs61931739 0.857 rs419112 chr12:34130528 A/G cg26384229 chr12:38710491 ALG10B 0.44 10.54 0.38 4.74e-24 Morning vs. evening chronotype; BRCA cis rs7586879 0.964 rs11688665 chr2:25121168 G/T cg01884057 chr2:25150051 NA 0.35 8.72 0.33 2.32e-17 Body mass index; BRCA cis rs9768139 0.658 rs896778 chr7:158113270 A/G cg24154853 chr7:158122151 PTPRN2 0.34 7.98 0.3 6.65e-15 Calcium levels; BRCA cis rs61935443 0.673 rs11107770 chr12:95275147 C/T cg21533806 chr12:95267307 NA -0.47 -9.07 -0.34 1.4e-18 Schizophrenia; BRCA cis rs875971 0.545 rs11767262 chr7:65767224 T/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.93 0.37 1.04e-21 Aortic root size; BRCA cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.66 14.3 0.49 1.97e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7715806 0.500 rs2307112 chr5:75003413 A/C cg19683494 chr5:74908142 NA 0.5 8.08 0.3 3.23e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.684 rs2363279 chr7:1096143 A/G cg22907277 chr7:1156413 C7orf50 0.38 8.19 0.31 1.48e-15 Longevity;Endometriosis; BRCA cis rs929596 0.639 rs2070959 chr2:234602191 A/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -9.37 -0.35 1.19e-19 Total bilirubin levels in HIV-1 infection; BRCA cis rs801193 1.000 rs10274773 chr7:66133578 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.39 -8.52 -0.32 1.15e-16 Aortic root size; BRCA cis rs4727027 0.801 rs12666337 chr7:148796253 C/T cg23583168 chr7:148888333 NA -0.82 -18.41 -0.59 4.68e-61 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7809950 1.000 rs2712191 chr7:107182724 C/G cg23024343 chr7:107201750 COG5 -0.4 -9.18 -0.34 6.12e-19 Coronary artery disease; BRCA cis rs11098499 0.775 rs10029303 chr4:120286755 T/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs1371614 0.523 rs12468721 chr2:27183751 G/A cg00617064 chr2:27272375 NA 0.31 8.04 0.3 4.34e-15 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs9325144 0.600 rs12227663 chr12:38734922 C/T cg26384229 chr12:38710491 ALG10B -0.52 -12.39 -0.44 9.86e-32 Morning vs. evening chronotype; BRCA trans rs11246602 1 rs11246602 chr11:51512090 T/C cg15704280 chr7:45808275 SEPT13 0.66 8.48 0.32 1.56e-16 HDL cholesterol levels;HDL cholesterol; BRCA cis rs60843830 0.661 rs11674325 chr2:105517 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.48 9.14 0.34 8.42e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6815814 0.950 rs55903115 chr4:38786474 C/A cg02016764 chr4:38805732 TLR1 -0.54 -8.84 -0.33 9.38e-18 Breast cancer; BRCA cis rs9291683 0.546 rs6820188 chr4:10051655 C/T cg11266682 chr4:10021025 SLC2A9 0.43 11.37 0.41 2.02e-27 Bone mineral density; BRCA cis rs6089584 0.962 rs6142913 chr20:60566950 A/G cg06108461 chr20:60628389 TAF4 -0.92 -19.95 -0.62 3.37e-69 Body mass index; BRCA cis rs11711311 0.747 rs7638449 chr3:113343646 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -9.08 -0.34 1.37e-18 IgG glycosylation; BRCA cis rs9291683 0.527 rs11727087 chr4:10096020 A/G cg02734326 chr4:10020555 SLC2A9 0.38 8.13 0.31 2.21e-15 Bone mineral density; BRCA cis rs9462846 0.919 rs9462851 chr6:42890602 A/G cg05552183 chr6:42928497 GNMT 0.44 8.17 0.31 1.6e-15 Blood protein levels; BRCA cis rs9291683 0.620 rs4444830 chr4:10124819 A/G cg11266682 chr4:10021025 SLC2A9 -0.38 -9.26 -0.34 3.1400000000000002e-19 Bone mineral density; BRCA cis rs6540559 0.673 rs1073150 chr1:210017083 G/A cg22029157 chr1:209979665 IRF6 0.41 8.01 0.3 5.25e-15 Cleft lip with or without cleft palate; BRCA cis rs4853012 0.838 rs4563249 chr2:74354016 G/T cg05890377 chr2:74357713 NA 0.49 12.12 0.43 1.46e-30 Gestational age at birth (maternal effect); BRCA cis rs6088590 0.610 rs6120663 chr20:33081906 A/C cg06115741 chr20:33292138 TP53INP2 -0.4 -8.59 -0.32 6.71e-17 Coronary artery disease; BRCA cis rs597539 0.652 rs622082 chr11:68703959 A/G cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 18.33 0.59 1.25e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7408868 0.563 rs11085949 chr19:15296917 G/T cg14696996 chr19:15285081 NOTCH3 0.81 12.23 0.44 4.8e-31 Pulse pressure; BRCA cis rs1552244 1.000 rs7631678 chr3:10078816 T/G cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA trans rs8002861 0.870 rs9567293 chr13:44447243 A/G cg17145862 chr1:211918768 LPGAT1 0.63 14.71 0.5 2.04e-42 Leprosy; BRCA cis rs597539 0.652 rs667989 chr11:68685776 T/A cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 18.25 0.59 3.31e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs6543140 0.964 rs2080288 chr2:103022166 G/A cg04239558 chr2:103089729 SLC9A4 0.33 9.29 0.35 2.31e-19 Blood protein levels; BRCA cis rs11098499 0.754 rs11732087 chr4:120239831 A/G cg09307838 chr4:120376055 NA 0.64 13.92 0.48 1.13e-38 Corneal astigmatism; BRCA cis rs13053817 1.000 rs13055707 chr22:29851172 G/A cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.47 -9.04 -0.34 1.81e-18 Carotid atherosclerosis in HIV infection; BRCA cis rs2153535 0.546 rs1335640 chr6:8485325 A/C cg21535247 chr6:8435926 SLC35B3 0.4 9.09 0.34 1.28e-18 Motion sickness; BRCA cis rs7119 0.717 rs12898281 chr15:77786903 C/T cg17802220 chr15:77601643 NA 0.46 10.29 0.38 4.38e-23 Type 2 diabetes; BRCA cis rs7312933 0.703 rs12371615 chr12:42563989 C/G cg01256987 chr12:42539512 GXYLT1 -0.47 -9.33 -0.35 1.67e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs7395581 0.959 rs901746 chr11:47260319 A/G cg25783544 chr11:47291846 MADD 0.37 8.17 0.31 1.68e-15 HDL cholesterol; BRCA cis rs11105298 0.838 rs10858862 chr12:89842053 T/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.85 -0.36 2.08e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs6815814 0.950 rs56408159 chr4:38812116 T/A cg06935464 chr4:38784597 TLR10 0.51 8.2 0.31 1.32e-15 Breast cancer; BRCA cis rs2066819 1.000 rs118130855 chr12:56677979 T/A cg26734620 chr12:56694298 CS 0.88 10.19 0.37 1.08e-22 Psoriasis vulgaris; BRCA cis rs11955398 0.625 rs10805370 chr5:59984244 A/T cg02684056 chr5:59996105 DEPDC1B 0.39 9.02 0.34 2.25e-18 Intelligence (multi-trait analysis); BRCA cis rs10751667 0.666 rs12295141 chr11:947065 G/A ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.14e-52 Alzheimer's disease (late onset); BRCA cis rs77633900 0.614 rs2170998 chr15:77007159 C/T cg21673338 chr15:77095150 SCAPER 0.51 9.83 0.36 2.45e-21 Non-glioblastoma glioma;Glioma; BRCA cis rs7975161 0.579 rs7962423 chr12:104710910 G/A cg25273343 chr12:104657179 TXNRD1 -0.56 -8.98 -0.33 2.92e-18 Toenail selenium levels; BRCA cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg27129171 chr3:47204927 SETD2 0.68 16.54 0.55 2.06e-51 Colorectal cancer; BRCA cis rs7766436 0.583 rs62389420 chr6:22557720 G/A cg13666174 chr6:22585274 NA -0.39 -7.91 -0.3 1.13e-14 Coronary artery disease; BRCA cis rs6665290 0.935 rs17600669 chr1:227201871 A/G cg10327440 chr1:227177885 CDC42BPA -1.14 -45.93 -0.88 1.27e-204 Myeloid white cell count; BRCA cis rs4665809 0.652 rs6728090 chr2:26524726 C/T cg22920501 chr2:26401640 FAM59B -0.72 -13.22 -0.46 1.86e-35 Gut microbiome composition (summer); BRCA cis rs801193 1.000 rs2659906 chr7:66165310 T/C cg11764359 chr7:65958608 NA 0.67 15.04 0.51 5.51e-44 Aortic root size; BRCA cis rs7520050 0.966 rs785489 chr1:46576390 A/G cg24296786 chr1:45957014 TESK2 0.41 9.12 0.34 9.96e-19 Red blood cell count;Reticulocyte count; BRCA cis rs6433857 0.536 rs1901750 chr2:181350739 C/T cg23363182 chr2:181467187 NA -0.37 -7.88 -0.3 1.42e-14 Body mass index; BRCA cis rs329648 0.667 rs11223616 chr11:133772838 C/T cg18057887 chr11:133800913 IGSF9B 0.4 8.2 0.31 1.37e-15 Parkinson's disease; BRCA cis rs7811142 0.943 rs10241492 chr7:99994813 A/G cg11814155 chr7:99998594 ZCWPW1 0.47 8.5 0.32 1.34e-16 Platelet count; BRCA cis rs9329221 0.868 rs7831557 chr8:10280228 C/T cg21775007 chr8:11205619 TDH -0.45 -8.81 -0.33 1.14e-17 Neuroticism; BRCA cis rs13108904 0.557 rs1250098 chr4:1238256 A/T cg20887711 chr4:1340912 KIAA1530 -0.6 -12.9 -0.45 5.24e-34 Obesity-related traits; BRCA trans rs6089829 1.000 rs62207535 chr20:61669187 A/G cg23505145 chr19:12996616 KLF1 0.57 12.57 0.45 1.49e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs4862750 0.874 rs6553027 chr4:187875777 T/C cg22105103 chr4:187893119 NA 0.38 11.89 0.43 1.3e-29 Lobe attachment (rater-scored or self-reported); BRCA cis rs7772486 0.558 rs7753273 chr6:146066039 C/T cg23711669 chr6:146136114 FBXO30 -0.73 -15.58 -0.52 1.22e-46 Lobe attachment (rater-scored or self-reported); BRCA cis rs2842992 0.789 rs7765490 chr6:160204326 C/T cg16489826 chr6:160211363 TCP1;MRPL18 0.58 12.08 0.43 2.01e-30 Age-related macular degeneration (geographic atrophy); BRCA trans rs60843830 1.000 rs55753056 chr2:243929 G/A cg11347411 chr7:150020925 ACTR3C;LRRC61 0.62 13.9 0.48 1.45e-38 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs1891275 0.515 rs1418161 chr10:93484655 C/G cg07889827 chr10:93443413 NA -0.4 -10.92 -0.4 1.39e-25 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs2315281 chr19:19480099 G/A cg01262667 chr19:19385393 TM6SF2 -0.42 -10.94 -0.4 1.16e-25 Tonsillectomy; BRCA cis rs8072100 0.967 rs8075411 chr17:45676760 C/T cg25173405 chr17:45401733 C17orf57 0.49 9.94 0.37 9.55e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3858526 0.883 rs7481923 chr11:5933342 T/C cg13902645 chr11:5959945 NA -0.55 -11.19 -0.4 1.17e-26 DNA methylation (variation); BRCA cis rs6687430 0.543 rs7512495 chr1:10631237 C/T cg17425144 chr1:10567563 PEX14 0.55 12.29 0.44 2.51e-31 Hand grip strength; BRCA cis rs9818758 0.545 rs11717978 chr3:48969036 T/A cg00383909 chr3:49044727 WDR6 0.98 15.74 0.53 2.1e-47 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9443189 0.527 rs775059 chr6:76370130 G/T cg01950844 chr6:76311363 SENP6 0.83 13.39 0.47 3.38e-36 Prostate cancer; BRCA cis rs1163251 0.837 rs592762 chr1:120247355 A/G cg19096424 chr1:120255104 PHGDH 0.45 10.44 0.38 1.2e-23 Blood metabolite levels; BRCA trans rs7786808 0.741 rs7789415 chr7:158227617 C/T cg02030672 chr11:45687055 CHST1 0.39 8.3 0.31 6.43e-16 Obesity-related traits; BRCA cis rs3858526 0.917 rs9284148 chr11:5973185 G/C cg13902645 chr11:5959945 NA -0.54 -10.91 -0.4 1.58e-25 DNA methylation (variation); BRCA cis rs10924970 0.967 rs10754589 chr1:235439755 T/C cg26050004 chr1:235667680 B3GALNT2 0.35 8.69 0.33 3.01e-17 Asthma; BRCA cis rs523522 0.962 rs655530 chr12:121022275 T/C cg12219531 chr12:120966889 COQ5 0.55 11.61 0.42 2.02e-28 High light scatter reticulocyte count; BRCA cis rs796364 0.789 rs176008 chr2:200814720 A/T cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 11.94 0.43 8.59e-30 Schizophrenia; BRCA cis rs782590 0.774 rs2627773 chr2:55900459 A/G cg18811423 chr2:55921094 PNPT1 0.78 26.76 0.73 2.14e-106 Metabolic syndrome; BRCA trans rs11098499 0.820 rs6534140 chr4:120455311 C/T cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs6831352 0.918 rs29001232 chr4:100046654 G/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs11608355 0.545 rs7315846 chr12:109908617 T/C cg05360138 chr12:110035743 NA 0.71 13.05 0.46 1.11e-34 Neuroticism; BRCA cis rs1707322 1.000 rs946527 chr1:46485970 C/T cg06784218 chr1:46089804 CCDC17 0.45 10.91 0.4 1.58e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4268898 0.932 rs7577964 chr2:24598279 A/G cg06627628 chr2:24431161 ITSN2 0.45 9.39 0.35 1.08e-19 Asthma; BRCA cis rs4853012 0.941 rs2421752 chr2:74341615 A/G cg20891558 chr2:74357851 NA 0.56 11.91 0.43 1.12e-29 Gestational age at birth (maternal effect); BRCA cis rs10771431 0.817 rs10843149 chr12:9362067 G/A cg08997352 chr12:9597637 DDX12 -0.57 -11.35 -0.41 2.6e-27 Breast size; BRCA cis rs17376456 0.825 rs17374166 chr5:93238655 T/C cg21475434 chr5:93447410 FAM172A 0.68 8.66 0.32 3.96e-17 Diabetic retinopathy; BRCA cis rs6840360 0.593 rs3805356 chr4:152680701 C/T cg22705602 chr4:152727874 NA 0.38 10.4 0.38 1.66e-23 Intelligence (multi-trait analysis); BRCA cis rs672059 0.967 rs657901 chr1:183163411 T/G ch.1.3577855R chr1:183094577 LAMC1 0.37 8.37 0.31 3.6e-16 Hypertriglyceridemia; BRCA cis rs11105298 0.891 rs12369195 chr12:89934972 G/C cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.45 -0.35 6.41e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs35306767 0.903 rs12249634 chr10:872744 G/A cg20503657 chr10:835505 NA 0.92 15.43 0.52 6.6e-46 Eosinophil percentage of granulocytes; BRCA cis rs2882667 0.931 rs13153618 chr5:138352776 C/A cg04439458 chr5:138467593 SIL1 -0.34 -9.37 -0.35 1.27e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs2197308 0.813 rs11504316 chr12:38219320 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.67 -0.36 1.02e-20 Morning vs. evening chronotype; BRCA cis rs4803455 0.565 rs11083616 chr19:41865643 A/G cg09537434 chr19:41945824 ATP5SL 0.63 13.25 0.46 1.38e-35 Migraine;Coronary artery disease; BRCA cis rs56104184 0.723 rs73063522 chr19:49408358 C/G cg15549821 chr19:49342101 PLEKHA4 -0.65 -9.9 -0.36 1.3e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs1005277 0.505 rs200939 chr10:38139483 T/C cg00409905 chr10:38381863 ZNF37A -0.49 -10.48 -0.38 8.07e-24 Extrinsic epigenetic age acceleration; BRCA cis rs9517313 0.897 rs4772087 chr13:99115041 A/G cg20487152 chr13:99095054 FARP1 0.33 8.78 0.33 1.51e-17 Neuroticism; BRCA cis rs698833 0.798 rs1067391 chr2:44639434 T/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 10.15 0.37 1.51e-22 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs7666738 0.515 rs10015315 chr4:98700137 A/G cg05340658 chr4:99064831 C4orf37 0.56 11.1 0.4 2.59e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs2576037 0.526 rs605487 chr18:44444778 G/C cg19077165 chr18:44547161 KATNAL2 -0.53 -11.44 -0.41 1.11e-27 Personality dimensions; BRCA cis rs35110281 0.744 rs8131027 chr21:45104908 G/C cg21573476 chr21:45109991 RRP1B -0.35 -9.52 -0.35 3.6e-20 Mean corpuscular volume; BRCA cis rs939658 0.805 rs59104559 chr15:79438784 A/G cg17916960 chr15:79447300 NA -0.43 -11.02 -0.4 5.66e-26 Refractive error; BRCA cis rs7772486 0.727 rs11155442 chr6:146140725 T/C cg23711669 chr6:146136114 FBXO30 0.79 19.28 0.61 1.28e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs7633770 0.786 rs1402148 chr3:46678295 C/T cg11219411 chr3:46661640 NA 0.61 15.66 0.53 5.12e-47 Coronary artery disease; BRCA cis rs9368481 0.761 rs9357030 chr6:26985026 G/T cg10547057 chr6:26987810 LOC100270746;C6orf41 -0.33 -10.21 -0.37 8.77e-23 Autism spectrum disorder or schizophrenia; BRCA cis rs2295359 0.892 rs10889657 chr1:67615487 A/G cg03340356 chr1:67600835 NA 0.35 7.84 0.3 1.88e-14 Psoriasis; BRCA cis rs2019137 0.868 rs3748916 chr2:113984033 C/T cg07594247 chr2:113993304 PAX8;LOC440839;LOC654433 -0.58 -11.46 -0.41 9.1e-28 Lymphocyte counts; BRCA cis rs2280018 1.000 rs2280017 chr16:15151361 A/G cg07549590 chr16:15018862 NA 0.33 8.27 0.31 7.81e-16 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs6088580 0.634 rs2378133 chr20:32919505 C/G cg24642439 chr20:33292090 TP53INP2 -0.54 -11.55 -0.42 3.59e-28 Glomerular filtration rate (creatinine); BRCA cis rs10479542 1.000 rs10479542 chr5:178981241 T/A cg22764044 chr5:178986830 RUFY1 0.46 12.4 0.44 8.53e-32 Lung cancer; BRCA cis rs2019137 0.967 rs895412 chr2:113973964 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.61 -12.69 -0.45 4.34e-33 Lymphocyte counts; BRCA cis rs881375 0.900 rs1930786 chr9:123691469 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 11.0 0.4 6.87e-26 Rheumatoid arthritis; BRCA cis rs7178424 1.000 rs11633500 chr15:62372475 A/G cg00456672 chr15:62358751 C2CD4A -0.36 -8.24 -0.31 9.42e-16 Height; BRCA cis rs1008375 0.966 rs28750296 chr4:17685826 A/T cg04450456 chr4:17643702 FAM184B 0.37 10.86 0.39 2.57e-25 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs35110281 0.807 rs4818850 chr21:45028071 T/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.39 8.4 0.32 2.82e-16 Mean corpuscular volume; BRCA cis rs507080 0.922 rs561845 chr11:118558827 A/G cg09144398 chr11:118550485 TREH -0.37 -8.96 -0.33 3.5e-18 Serum metabolite levels; BRCA cis rs9287719 0.649 rs10183359 chr2:10733044 G/A cg00105475 chr2:10696890 NA 0.41 9.23 0.34 3.83e-19 Prostate cancer; BRCA cis rs6088580 0.609 rs6058029 chr20:32969643 T/C cg24642439 chr20:33292090 TP53INP2 -0.55 -11.83 -0.42 2.57e-29 Glomerular filtration rate (creatinine); BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.89 -0.3 1.31e-14 Total body bone mineral density; BRCA cis rs1568889 1.000 rs11826837 chr11:28322566 C/G cg06544937 chr11:28130018 METT5D1;KIF18A -0.61 -13.45 -0.47 1.74e-36 Bipolar disorder; BRCA cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg05834845 chr3:195489306 MUC4 0.55 8.22 0.31 1.14e-15 Lung disease severity in cystic fibrosis; BRCA cis rs6570726 1.000 rs373778 chr6:145873252 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.85 0.51 4.4e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs56235637 chr8:58106008 T/C cg20607798 chr8:58055168 NA 0.47 8.04 0.3 4.43e-15 Developmental language disorder (linguistic errors); BRCA cis rs6879260 1.000 rs888922 chr5:179731635 C/G cg23221052 chr5:179740743 GFPT2 -0.67 -14.09 -0.49 1.93e-39 Height; BRCA cis rs1552244 0.572 rs41464050 chr3:10158393 A/G cg08888203 chr3:10149979 C3orf24 0.63 11.56 0.42 3.44e-28 Alzheimer's disease; BRCA cis rs514406 0.708 rs546334 chr1:53326210 T/C cg24675658 chr1:53192096 ZYG11B -0.68 -15.46 -0.52 4.76e-46 Monocyte count; BRCA cis rs9487051 1.000 rs9487052 chr6:109617086 C/T cg21918786 chr6:109611834 NA -0.44 -11.95 -0.43 7.83e-30 Reticulocyte fraction of red cells; BRCA cis rs9527 0.590 rs2148200 chr10:104879847 C/A cg04362960 chr10:104952993 NT5C2 0.46 10.74 0.39 7.57e-25 Arsenic metabolism; BRCA cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.41 -8.7 -0.33 2.74e-17 Bipolar disorder; BRCA cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg18446336 chr7:2847575 GNA12 -0.35 -8.25 -0.31 9.28e-16 Height; BRCA cis rs12612619 0.732 rs6547401 chr2:27284845 A/G cg00617064 chr2:27272375 NA -0.32 -8.39 -0.32 3.05e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs10821556 1 rs10821556 chr9:136942136 C/A cg13758054 chr9:136930777 BRD3 0.29 8.4 0.32 2.9e-16 Mean platelet volume; BRCA cis rs6088580 0.634 rs6120666 chr20:33090718 A/G cg24642439 chr20:33292090 TP53INP2 0.54 11.72 0.42 6.96e-29 Glomerular filtration rate (creatinine); BRCA cis rs208520 0.690 rs12209753 chr6:66703951 A/G cg07460842 chr6:66804631 NA 0.97 19.47 0.61 1.26e-66 Exhaled nitric oxide output; BRCA trans rs7618501 0.933 rs6809431 chr3:49804119 A/G cg21659725 chr3:3221576 CRBN 0.7 20.95 0.64 1.37e-74 Intelligence (multi-trait analysis); BRCA cis rs4595586 0.546 rs11169801 chr12:39241429 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.61 0.32 5.71e-17 Morning vs. evening chronotype; BRCA cis rs12541635 0.966 rs6987512 chr8:106998770 C/T cg10147462 chr8:107024639 NA 0.37 10.15 0.37 1.5e-22 Age of smoking initiation; BRCA cis rs11227306 0.934 rs11227315 chr11:65590389 C/A cg00576331 chr11:65640516 EFEMP2 -0.38 -7.89 -0.3 1.32e-14 DNA methylation (variation); BRCA cis rs2153535 0.580 rs9505458 chr6:8479215 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 4.98e-18 Motion sickness; BRCA trans rs9388451 0.626 rs1343115 chr6:126069817 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.57 -14.12 -0.49 1.27e-39 Brugada syndrome; BRCA cis rs3733585 0.638 rs17185835 chr4:9958180 T/G cg00071950 chr4:10020882 SLC2A9 -0.44 -10.42 -0.38 1.38e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs921968 0.541 rs593888 chr2:219427597 A/G cg02176678 chr2:219576539 TTLL4 0.46 12.11 0.43 1.52e-30 Mean corpuscular hemoglobin concentration; BRCA cis rs1008375 0.932 rs2302394 chr4:17641188 A/G cg15017067 chr4:17643749 FAM184B 0.3 8.52 0.32 1.15e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6570726 0.791 rs447992 chr6:145817184 C/T cg23711669 chr6:146136114 FBXO30 0.77 17.96 0.58 1.11e-58 Lobe attachment (rater-scored or self-reported); BRCA cis rs12950390 0.853 rs10445375 chr17:45864314 C/T cg24803719 chr17:45855879 NA 0.3 7.91 0.3 1.14e-14 IgG glycosylation; BRCA cis rs7647973 1.000 rs892974 chr3:49398514 C/A cg07636037 chr3:49044803 WDR6 0.76 15.38 0.52 1.27e-45 Menarche (age at onset); BRCA cis rs400736 0.602 rs10864330 chr1:8168564 C/T cg25007680 chr1:8021821 PARK7 -0.35 -8.68 -0.32 3.37e-17 Response to antidepressants and depression; BRCA cis rs9807989 0.507 rs3732124 chr2:103018052 A/G cg03938978 chr2:103052716 IL18RAP -0.3 -8.76 -0.33 1.79e-17 Asthma; BRCA cis rs35849525 1.000 rs35849525 chr3:50067350 T/C cg24110177 chr3:50126178 RBM5 -0.45 -9.67 -0.36 1.01e-20 Intelligence (multi-trait analysis); BRCA cis rs769267 0.895 rs2965189 chr19:19519518 G/T cg17414380 chr19:19431394 KIAA0892;SF4 0.43 8.98 0.33 2.96e-18 Tonsillectomy; BRCA cis rs13191362 1.000 rs2156257 chr6:163100710 G/T cg14584255 chr6:163149320 PACRG;PARK2 0.63 10.21 0.37 9.1e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs57590327 0.555 rs3943556 chr3:81738892 G/C cg07356753 chr3:81810745 GBE1 -0.47 -11.19 -0.4 1.09e-26 Extraversion; BRCA cis rs35110281 0.641 rs9978858 chr21:45085552 A/G cg21573476 chr21:45109991 RRP1B -0.47 -11.68 -0.42 1.02e-28 Mean corpuscular volume; BRCA cis rs1707322 1.000 rs6429588 chr1:46454058 T/G cg03146154 chr1:46216737 IPP 0.45 9.9 0.36 1.36e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs514406 0.525 rs269291 chr1:53189297 C/T cg16325326 chr1:53192061 ZYG11B 0.96 27.09 0.73 3.27e-108 Monocyte count; BRCA trans rs34421088 0.564 rs6983129 chr8:11591136 A/C cg15556689 chr8:8085844 FLJ10661 0.31 8.04 0.3 4.5e-15 Neuroticism; BRCA cis rs2882667 0.898 rs10045761 chr5:138397289 G/A cg04439458 chr5:138467593 SIL1 -0.35 -9.45 -0.35 6.18e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7552404 1.000 rs11163924 chr1:76132070 A/C cg22875332 chr1:76189707 ACADM -0.68 -14.53 -0.5 1.62e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1018836 0.923 rs13268594 chr8:91588545 G/T cg16814680 chr8:91681699 NA -0.57 -12.27 -0.44 3.19e-31 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA trans rs11098499 1.000 rs35643470 chr4:120184948 T/C cg25214090 chr10:38739885 LOC399744 0.48 10.7 0.39 1.1e-24 Corneal astigmatism; BRCA cis rs6121246 0.909 rs6058460 chr20:30363071 G/A cg21427119 chr20:30132790 HM13 -0.4 -8.43 -0.32 2.34e-16 Mean corpuscular hemoglobin; BRCA cis rs490234 0.934 rs4837018 chr9:128275991 A/G cg14078157 chr9:128172775 NA -0.33 -8.04 -0.3 4.47e-15 Mean arterial pressure; BRCA cis rs10504229 0.609 rs56289889 chr8:58116276 G/C cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs7264396 0.790 rs2425097 chr20:34308926 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.97 -0.53 1.42e-48 Total cholesterol levels; BRCA cis rs1801251 1.000 rs1867778 chr2:233679644 C/T cg08000102 chr2:233561755 GIGYF2 -0.62 -13.57 -0.47 5.01e-37 Coronary artery disease; BRCA cis rs868036 0.958 rs3784709 chr15:68072275 C/T cg08079166 chr15:68083412 MAP2K5 0.33 8.51 0.32 1.21e-16 Restless legs syndrome; BRCA cis rs4595586 0.525 rs7136425 chr12:39376005 C/A cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA trans rs11039798 0.512 rs3974936 chr11:49005012 C/T cg03929089 chr4:120376271 NA 0.57 9.47 0.35 5.22e-20 Axial length; BRCA cis rs7953508 0.506 rs930316 chr12:93967035 A/G cg18151635 chr12:93972918 NA -0.46 -9.27 -0.34 2.83e-19 Pubertal anthropometrics; BRCA trans rs4650994 0.544 rs11579513 chr1:178496092 T/C cg05059571 chr16:84539110 KIAA1609 -0.49 -11.06 -0.4 4.05e-26 HDL cholesterol levels;HDL cholesterol; BRCA cis rs10206020 0.842 rs7590900 chr2:1574902 A/G cg01028140 chr2:1542097 TPO -0.57 -11.74 -0.42 5.83e-29 IgG glycosylation; BRCA cis rs11252926 0.583 rs4881333 chr10:519164 G/C cg18196295 chr10:418757 DIP2C 0.39 8.78 0.33 1.46e-17 Psychosis in Alzheimer's disease; BRCA cis rs7811142 0.943 rs67196635 chr7:100025564 T/C cg00814883 chr7:100076585 TSC22D4 -0.52 -11.77 -0.42 4.38e-29 Platelet count; BRCA cis rs1215050 0.740 rs1214994 chr4:99035577 C/T cg05340658 chr4:99064831 C4orf37 0.48 11.13 0.4 2.08e-26 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg17724175 chr1:150552817 MCL1 0.27 8.83 0.33 9.73e-18 Tonsillectomy; BRCA cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg26119090 chr2:26468346 HADHA;HADHB -0.63 -11.37 -0.41 2.14e-27 Gut microbiome composition (summer); BRCA cis rs12477438 0.798 rs1453561 chr2:99613924 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.73 -17.03 -0.56 6.87e-54 Chronic sinus infection; BRCA cis rs9325144 0.560 rs1843910 chr12:38677408 T/C cg13010199 chr12:38710504 ALG10B -0.37 -8.84 -0.33 9e-18 Morning vs. evening chronotype; BRCA trans rs6951245 0.938 rs117729148 chr7:1108531 G/A cg13565492 chr6:43139072 SRF -0.84 -11.44 -0.41 1.02e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg21573476 chr21:45109991 RRP1B -0.32 -8.15 -0.31 1.94e-15 Mean corpuscular volume; BRCA cis rs600806 0.815 rs10858097 chr1:109967324 C/A cg20591472 chr1:110008990 SYPL2 0.32 7.99 0.3 6.35e-15 Intelligence (multi-trait analysis); BRCA cis rs11690935 0.531 rs62183800 chr2:172867273 C/T cg13550731 chr2:172543902 DYNC1I2 0.49 12.11 0.43 1.55e-30 Schizophrenia; BRCA cis rs875971 1.000 rs811880 chr7:65818646 T/C cg11764359 chr7:65958608 NA 0.79 19.35 0.61 5.48e-66 Aortic root size; BRCA cis rs7044106 0.791 rs4837793 chr9:123483621 G/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.69 14.92 0.51 1.98e-43 Hip circumference adjusted for BMI; BRCA cis rs1003719 0.708 rs2000417 chr21:38502868 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA trans rs11098499 0.909 rs2127821 chr4:120394535 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.84 -0.3 1.96e-14 Corneal astigmatism; BRCA cis rs12477438 0.520 rs2516827 chr2:99772565 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs950776 0.518 rs4886571 chr15:78833758 G/A cg22563815 chr15:78856949 CHRNA5 -0.35 -8.39 -0.31 3.18e-16 Sudden cardiac arrest; BRCA cis rs2717559 0.542 rs2717586 chr8:143897882 C/T cg02415014 chr8:143852576 LYNX1 -0.33 -8.27 -0.31 7.65e-16 Urinary tract infection frequency; BRCA cis rs3768617 0.510 rs1886501 chr1:183095234 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.53 0.57 1.78e-56 Fuchs's corneal dystrophy; BRCA cis rs9814567 1.000 rs6765505 chr3:134208132 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.01 -0.34 2.31e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4555082 0.874 rs2015978 chr14:105720134 G/C cg06808227 chr14:105710500 BRF1 -0.8 -16.15 -0.54 1.82e-49 Mean platelet volume;Platelet distribution width; BRCA cis rs8058578 1.000 rs3747481 chr16:30666367 C/T cg02466173 chr16:30829666 NA -0.54 -11.61 -0.42 2.07e-28 Multiple myeloma; BRCA cis rs9309473 0.554 rs4330127 chr2:73581320 A/T cg20560298 chr2:73613845 ALMS1 -0.42 -10.91 -0.4 1.53e-25 Metabolite levels; BRCA cis rs769267 0.965 rs12977937 chr19:19429975 C/G cg03709012 chr19:19516395 GATAD2A 0.75 17.13 0.56 2.09e-54 Tonsillectomy; BRCA cis rs60871478 0.636 rs56393680 chr7:885696 A/G cg05535760 chr7:792225 HEATR2 -0.77 -11.66 -0.42 1.22e-28 Cerebrospinal P-tau181p levels; BRCA cis rs11229555 0.645 rs10466679 chr11:58188257 T/C cg15696309 chr11:58395628 NA -0.44 -9.41 -0.35 8.7e-20 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs738322 0.967 rs2092180 chr22:38571563 A/G cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA trans rs747782 0.582 rs11039571 chr11:48207259 G/A cg15704280 chr7:45808275 SEPT13 0.56 8.74 0.33 2.02e-17 Intraocular pressure; BRCA cis rs4555082 0.834 rs11849607 chr14:105745383 G/A cg10792982 chr14:105748885 BRF1 0.5 11.67 0.42 1.15e-28 Mean platelet volume;Platelet distribution width; BRCA cis rs12142240 0.698 rs41534051 chr1:46828734 A/G cg00530320 chr1:46809349 NSUN4 0.5 9.94 0.37 9.36e-22 Menopause (age at onset); BRCA cis rs11676348 0.846 rs4674259 chr2:218991005 C/T cg20019365 chr2:219134978 PNKD;AAMP -0.38 -7.92 -0.3 1.07e-14 Ulcerative colitis; BRCA trans rs1459104 1.000 rs2903534 chr11:55054044 A/G cg03929089 chr4:120376271 NA 0.65 7.9 0.3 1.19e-14 Body mass index; BRCA cis rs2842992 0.830 rs2758313 chr6:160154099 C/G cg19482086 chr6:160211437 TCP1;MRPL18 0.67 17.27 0.56 4.14e-55 Age-related macular degeneration (geographic atrophy); BRCA cis rs853679 0.546 rs200989 chr6:27816442 A/G cg26587870 chr6:27730563 NA -0.54 -8.14 -0.31 2.11e-15 Depression; BRCA cis rs6761276 0.649 rs3811055 chr2:113831182 A/T cg12858261 chr2:113808755 IL1F8 0.43 8.53 0.32 1.1e-16 Protein quantitative trait loci; BRCA cis rs2153535 0.580 rs6597330 chr6:8492076 T/C cg23788917 chr6:8435910 SLC35B3 0.49 10.64 0.39 1.94e-24 Motion sickness; BRCA cis rs2115630 1.000 rs55646601 chr15:85323568 G/T cg11189052 chr15:85197271 WDR73 -0.35 -8.29 -0.31 6.86e-16 P wave terminal force; BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg25036284 chr2:26402008 FAM59B -0.63 -10.95 -0.4 1.05e-25 Gut microbiome composition (summer); BRCA cis rs6087990 0.735 rs2065576 chr20:31389009 C/T cg13636640 chr20:31349939 DNMT3B 0.62 17.13 0.56 2.03e-54 Ulcerative colitis; BRCA cis rs9790314 0.723 rs10936223 chr3:160884313 C/A cg03342759 chr3:160939853 NMD3 -0.58 -13.09 -0.46 7.66e-35 Morning vs. evening chronotype; BRCA cis rs736408 0.609 rs2268025 chr3:52795224 A/T cg18404041 chr3:52824283 ITIH1 -0.44 -12.92 -0.46 4.26e-34 Bipolar disorder; BRCA cis rs2197308 0.703 rs10880251 chr12:37903297 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.99 0.56 1.04e-53 Morning vs. evening chronotype; BRCA cis rs4853036 1.000 rs11903034 chr2:70060278 T/G cg02498382 chr2:70120550 SNRNP27 -0.49 -9.12 -0.34 9.96e-19 Colorectal or endometrial cancer; BRCA cis rs586533 0.881 rs676086 chr11:99506539 T/C cg22878054 chr11:99397252 CNTN5 0.32 8.13 0.31 2.3e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs1580019 0.510 rs4723162 chr7:32543804 C/A cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.26 0.31 8.13e-16 Cognitive ability; BRCA cis rs12210905 0.687 rs12191649 chr6:27421208 A/T cg08851530 chr6:28072375 NA 0.81 7.89 0.3 1.3e-14 Hip circumference adjusted for BMI; BRCA cis rs9768139 0.733 rs921617 chr7:158118198 A/G cg24154853 chr7:158122151 PTPRN2 0.35 8.16 0.31 1.73e-15 Calcium levels; BRCA cis rs9300255 0.544 rs1716174 chr12:123660717 T/C cg00376283 chr12:123451042 ABCB9 0.51 9.74 0.36 5.37e-21 Neutrophil percentage of white cells; BRCA cis rs919433 0.617 rs700642 chr2:198600730 G/T cg00792783 chr2:198669748 PLCL1 -0.47 -10.16 -0.37 1.45e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10504229 1.000 rs75037501 chr8:58170136 T/G cg24829409 chr8:58192753 C8orf71 -0.61 -12.58 -0.45 1.41e-32 Developmental language disorder (linguistic errors); BRCA cis rs2303759 0.670 rs45549132 chr19:49794028 G/T cg22307029 chr19:49891270 CCDC155 0.47 7.91 0.3 1.15e-14 Multiple sclerosis; BRCA cis rs4689388 0.926 rs5018648 chr4:6292818 C/G cg25554036 chr4:6271136 WFS1 -0.41 -9.91 -0.37 1.19e-21 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2153535 0.580 rs6910742 chr6:8448328 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.9 0.33 5.55e-18 Motion sickness; BRCA cis rs6867032 0.695 rs3902820 chr5:2000330 T/A cg26168224 chr5:2018326 NA -0.56 -14.49 -0.5 2.52e-41 Gut microbiome composition (winter); BRCA cis rs2072499 0.750 rs909269 chr1:156192028 C/T cg24450063 chr1:156163899 SLC25A44 0.93 17.51 0.57 2.29e-56 Testicular germ cell tumor; BRCA cis rs35110281 0.744 rs230644 chr21:44917183 C/T cg01579765 chr21:45077557 HSF2BP 0.36 9.58 0.35 2.08e-20 Mean corpuscular volume; BRCA cis rs13190036 0.591 rs78523677 chr5:176551103 C/A cg06733329 chr5:176740039 MXD3 0.4 7.97 0.3 7.47e-15 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs12701220 0.604 rs12702122 chr7:1149494 C/G cg16145915 chr7:1198662 ZFAND2A -0.46 -9.24 -0.34 3.48e-19 Bronchopulmonary dysplasia; BRCA cis rs367943 0.799 rs10478135 chr5:112976905 C/A cg12552261 chr5:112820674 MCC 0.51 9.89 0.36 1.48e-21 Type 2 diabetes; BRCA cis rs61990749 0.597 rs8016447 chr14:78222068 C/T cg02301378 chr14:78227641 SNW1;C14orf178 0.63 9.73 0.36 5.64e-21 Fibroblast growth factor basic levels; BRCA cis rs2204008 0.665 rs11179830 chr12:38220966 T/C cg26384229 chr12:38710491 ALG10B 0.67 15.18 0.51 1.13e-44 Bladder cancer; BRCA cis rs2836974 0.863 rs8132333 chr21:40527900 A/G cg11890956 chr21:40555474 PSMG1 1.06 30.81 0.77 1.95e-128 Cognitive function; BRCA cis rs250677 0.522 rs6872172 chr5:148359529 G/C cg12140854 chr5:148520817 ABLIM3 0.41 8.32 0.31 5.16e-16 Breast cancer; BRCA trans rs12517041 1.000 rs2356713 chr5:23284777 T/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.9 -0.3 1.19e-14 Calcium levels; BRCA trans rs2204008 0.837 rs11519926 chr12:38348992 G/A cg06521331 chr12:34319734 NA -0.52 -9.3 -0.35 2.25e-19 Bladder cancer; BRCA cis rs826838 0.935 rs11169547 chr12:39185625 C/A cg26384229 chr12:38710491 ALG10B 0.8 19.69 0.61 7.86e-68 Heart rate; BRCA trans rs637571 0.522 rs493899 chr11:65747952 A/C cg17712092 chr4:129076599 LARP1B 0.54 13.2 0.46 2.27e-35 Eosinophil percentage of white cells; BRCA cis rs1949733 1.000 rs868105 chr4:8501030 G/T cg11789530 chr4:8429930 ACOX3 -0.69 -17.98 -0.58 8.05e-59 Response to antineoplastic agents; BRCA cis rs7809950 0.817 rs10224503 chr7:107075569 A/C cg23024343 chr7:107201750 COG5 -0.49 -10.74 -0.39 7.33e-25 Coronary artery disease; BRCA cis rs875971 0.638 rs801216 chr7:66011667 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -8.07 -0.3 3.56e-15 Aortic root size; BRCA cis rs7618915 0.547 rs6976 chr3:52728804 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.36 11.2 0.41 1.05e-26 Bipolar disorder; BRCA cis rs10504229 0.683 rs7838958 chr8:58136968 T/C cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs7617773 0.963 rs9822496 chr3:48181333 T/C cg11946769 chr3:48343235 NME6 0.39 8.72 0.33 2.48e-17 Coronary artery disease; BRCA cis rs11051970 0.879 rs2651362 chr12:32587851 G/C cg02745156 chr12:32552066 NA 0.27 8.87 0.33 7.25e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs30380 0.632 rs27045 chr5:96138861 C/T cg16492584 chr5:96139282 ERAP1 -0.47 -11.25 -0.41 6.42e-27 Cerebrospinal fluid biomarker levels; BRCA cis rs6912958 0.702 rs6906769 chr6:88235949 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.42 -0.32 2.54e-16 Monocyte percentage of white cells; BRCA cis rs4862750 0.872 rs7658314 chr4:187900356 T/C cg07414643 chr4:187882934 NA 0.28 9.61 0.36 1.65e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs758324 0.812 rs30159 chr5:131306535 T/C cg06307176 chr5:131281290 NA -0.41 -8.5 -0.32 1.38e-16 Alzheimer's disease in APOE e4- carriers; BRCA cis rs1552244 0.810 rs35711405 chr3:10116939 C/T cg08888203 chr3:10149979 C3orf24 0.67 13.93 0.48 9.94e-39 Alzheimer's disease; BRCA trans rs561341 1.000 rs111454793 chr17:30319267 T/C cg27661571 chr11:113659931 NA -0.73 -11.22 -0.41 8.26e-27 Hip circumference adjusted for BMI; BRCA cis rs7394190 0.748 rs2075641 chr10:75562108 G/A cg07699608 chr10:75541558 CHCHD1 0.69 10.37 0.38 2.17e-23 Incident atrial fibrillation; BRCA cis rs4891159 0.724 rs690639 chr18:74108957 C/T cg24786174 chr18:74118243 ZNF516 0.73 18.01 0.58 6.04e-59 Longevity; BRCA cis rs11758351 0.587 rs2050950 chr6:26234883 A/G cg01420254 chr6:26195488 NA 0.55 8.56 0.32 8.23e-17 Gout;Renal underexcretion gout; BRCA cis rs2836974 0.653 rs8130556 chr21:40516872 C/T cg11644478 chr21:40555479 PSMG1 0.77 16.62 0.55 8.14e-52 Cognitive function; BRCA cis rs910316 1.000 rs8003506 chr14:75586288 A/C cg08847533 chr14:75593920 NEK9 -0.93 -23.37 -0.68 8.68e-88 Height; BRCA cis rs1005277 0.579 rs116912400 chr10:38479207 G/T cg18963800 chr10:38644991 HSD17B7P2 -0.4 -7.91 -0.3 1.12e-14 Extrinsic epigenetic age acceleration; BRCA cis rs1552244 0.808 rs7615088 chr3:10035896 A/T cg08888203 chr3:10149979 C3orf24 0.56 11.7 0.42 9.05e-29 Alzheimer's disease; BRCA cis rs7918232 0.941 rs1753413 chr10:27397112 T/C cg14240646 chr10:27532245 ACBD5 -0.64 -9.38 -0.35 1.16e-19 Breast cancer; BRCA cis rs7615952 0.641 rs61048217 chr3:125807905 G/T cg06494592 chr3:125709126 NA -0.53 -8.22 -0.31 1.17e-15 Blood pressure (smoking interaction); BRCA cis rs3767633 0.925 rs6427639 chr1:161866372 C/A cg09175582 chr1:161736000 ATF6 0.52 8.43 0.32 2.32e-16 IgG glycosylation; BRCA cis rs1003719 0.762 rs34273703 chr21:38475019 A/G cg10648535 chr21:38446584 PIGP;TTC3 0.6 14.13 0.49 1.26e-39 Eye color traits; BRCA cis rs2516839 0.517 rs1556257 chr1:161051134 A/G cg11161846 chr1:160990452 F11R -0.36 -8.33 -0.31 5.04e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs6089584 0.927 rs3787427 chr20:60579789 T/C cg12751644 chr20:60527061 NA -0.33 -7.91 -0.3 1.1e-14 Body mass index; BRCA cis rs12586317 0.547 rs13379372 chr14:35483882 A/C cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 9.22e-23 Psoriasis; BRCA cis rs509477 1.000 rs7245165 chr18:32567007 C/A cg00449728 chr18:32561817 MAPRE2 0.34 8.01 0.3 5.55e-15 Cerebrospinal fluid AB1-42 levels; BRCA cis rs7312933 1.000 rs7312933 chr12:42503467 C/T cg01256987 chr12:42539512 GXYLT1 0.56 11.54 0.42 4.05e-28 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs12971120 0.947 rs8084410 chr18:72168486 T/C cg26446133 chr18:72167187 CNDP2 -0.79 -19.96 -0.62 2.82e-69 Refractive error; BRCA cis rs11690935 0.921 rs6710698 chr2:172596078 G/C cg13550731 chr2:172543902 DYNC1I2 -0.93 -32.26 -0.79 3.31e-136 Schizophrenia; BRCA cis rs997295 0.554 rs4261477 chr15:68073968 G/T cg08079166 chr15:68083412 MAP2K5 0.31 8.37 0.31 3.66e-16 Motion sickness; BRCA cis rs7618915 0.547 rs11130314 chr3:52697082 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.84 0.36 2.34e-21 Bipolar disorder; BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg25703541 chr22:24373054 LOC391322 0.73 16.91 0.56 2.69e-53 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7044106 0.537 rs10818474 chr9:123489964 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.6 12.06 0.43 2.65e-30 Hip circumference adjusted for BMI; BRCA cis rs7847628 0.765 rs7026635 chr9:123550027 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 -0.6 -10.56 -0.39 3.91e-24 Birth weight; BRCA trans rs9393777 0.778 rs66841633 chr6:27382386 G/T cg01620082 chr3:125678407 NA -0.7 -9.15 -0.34 7.58e-19 Intelligence (multi-trait analysis); BRCA cis rs12887734 0.524 rs12888002 chr14:104238647 T/C cg26031613 chr14:104095156 KLC1 -0.57 -9.67 -0.36 1e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs651907 0.557 rs11914318 chr3:101453858 C/T cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.18 -0.31 1.59e-15 Colorectal cancer; BRCA cis rs1153858 0.943 rs7402632 chr15:45701913 A/T cg21132104 chr15:45694354 SPATA5L1 0.73 15.67 0.53 4.65e-47 Homoarginine levels; BRCA cis rs61990749 0.597 rs117131659 chr14:78131126 C/T cg02301378 chr14:78227641 SNW1;C14orf178 -0.58 -8.92 -0.33 4.88e-18 Fibroblast growth factor basic levels; BRCA cis rs832540 0.898 rs252890 chr5:56226410 T/C cg24531977 chr5:56204891 C5orf35 -0.41 -8.37 -0.31 3.55e-16 Coronary artery disease; BRCA trans rs3808502 0.605 rs11784572 chr8:11174484 C/G cg15556689 chr8:8085844 FLJ10661 -0.34 -8.93 -0.33 4.47e-18 Neuroticism; BRCA trans rs7618501 0.633 rs13060128 chr3:50025028 A/G cg21659725 chr3:3221576 CRBN 0.46 11.55 0.42 3.53e-28 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.935 rs6058198 chr20:33748253 T/A cg24642439 chr20:33292090 TP53INP2 0.42 8.24 0.31 9.43e-16 Height; BRCA cis rs2777491 0.574 rs1757468 chr15:41743574 T/A cg18705301 chr15:41695430 NDUFAF1 -1.07 -27.73 -0.74 1.05e-111 Ulcerative colitis; BRCA cis rs6570726 0.577 rs399502 chr6:145805874 A/G cg13319975 chr6:146136371 FBXO30 -0.6 -13.4 -0.47 3e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs1691799 0.899 rs1168325 chr12:66728234 C/G cg16791601 chr12:66731901 HELB -0.65 -17.34 -0.57 1.74e-55 White blood cell count (basophil); BRCA cis rs1555322 0.530 rs2425043 chr20:33868702 T/C cg17927777 chr20:33865990 NA 0.42 7.91 0.3 1.11e-14 Attention deficit hyperactivity disorder; BRCA cis rs1371867 0.513 rs1542812 chr8:101207064 G/A cg06636551 chr8:101224915 SPAG1 0.49 11.6 0.42 2.33e-28 Atrioventricular conduction; BRCA cis rs8114671 0.562 rs6087651 chr20:33518353 C/T cg24642439 chr20:33292090 TP53INP2 0.43 9.12 0.34 1.01e-18 Height; BRCA cis rs736408 0.522 rs11130310 chr3:52674667 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.38 12.96 0.46 2.77e-34 Bipolar disorder; BRCA cis rs2072499 0.966 rs2984615 chr1:156165317 G/C cg06970220 chr1:156163860 SLC25A44 0.4 9.58 0.35 2.04e-20 Testicular germ cell tumor; BRCA trans rs61931739 0.534 rs10506120 chr12:34235603 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.58 0.35 2.14e-20 Morning vs. evening chronotype; BRCA cis rs3096299 0.900 rs3114867 chr16:89428967 A/C cg00750074 chr16:89608354 SPG7 -0.34 -9.17 -0.34 6.46e-19 Multiple myeloma (IgH translocation); BRCA trans rs61931739 0.534 rs1486886 chr12:34043619 C/T cg13010199 chr12:38710504 ALG10B 0.4 8.09 0.3 3.05e-15 Morning vs. evening chronotype; BRCA cis rs10256972 0.521 rs7811577 chr7:1102829 C/G cg07308232 chr7:1071921 C7orf50 -0.36 -7.87 -0.3 1.5e-14 Longevity;Endometriosis; BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg04234412 chr22:24373322 LOC391322 0.81 23.1 0.67 2.64e-86 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6545883 0.894 rs2121661 chr2:61561658 A/G cg15711740 chr2:61764176 XPO1 0.53 13.55 0.47 6.11e-37 Tuberculosis; BRCA trans rs9329221 0.657 rs17694485 chr8:10114458 A/T cg06636001 chr8:8085503 FLJ10661 0.49 9.52 0.35 3.53e-20 Neuroticism; BRCA cis rs8114671 0.562 rs725521 chr20:33516071 T/C cg24642439 chr20:33292090 TP53INP2 0.43 9.19 0.34 5.32e-19 Height; BRCA cis rs6582630 0.504 rs4882367 chr12:38330878 A/T cg26384229 chr12:38710491 ALG10B -0.42 -9.73 -0.36 5.75e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs4819052 1.000 rs3746980 chr21:46711580 C/T cg02159808 chr21:46707872 POFUT2;LOC642852 0.62 10.75 0.39 7.02e-25 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11644478 chr21:40555479 PSMG1 -0.68 -14.87 -0.51 3.75e-43 Cognitive function; BRCA cis rs796364 0.525 rs10931895 chr2:201143242 C/T cg23649088 chr2:200775458 C2orf69 0.45 7.94 0.3 8.82e-15 Schizophrenia; BRCA cis rs5769765 0.908 rs9616217 chr22:50318946 C/T cg02269571 chr22:50332266 NA -0.53 -9.8 -0.36 3.19e-21 Schizophrenia; BRCA cis rs9811920 0.609 rs704583 chr3:99643693 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.72 16.81 0.55 9.16e-53 Axial length; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg18765753 chr7:1198926 ZFAND2A -0.56 -14.93 -0.51 1.85e-43 Longevity;Endometriosis; BRCA cis rs1005277 0.579 rs2505257 chr10:38372664 A/G cg25427524 chr10:38739819 LOC399744 -0.69 -16.64 -0.55 6.29e-52 Extrinsic epigenetic age acceleration; BRCA cis rs6570726 0.791 rs370112 chr6:145859853 T/G cg23711669 chr6:146136114 FBXO30 0.8 19.0 0.6 3.6e-64 Lobe attachment (rater-scored or self-reported); BRCA cis rs5750830 0.649 rs5757657 chr22:39798429 G/T cg11247378 chr22:39784982 NA -0.63 -15.43 -0.52 6.89e-46 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs17528590 chr2:26505858 A/G cg25036284 chr2:26402008 FAM59B 0.96 16.04 0.54 6.76e-49 Gut microbiome composition (summer); BRCA cis rs1568889 1.000 rs12791341 chr11:28335452 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.61 13.1 0.46 6.59e-35 Bipolar disorder; BRCA cis rs10504229 0.683 rs11786043 chr8:58133174 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs1552244 1.000 rs61077902 chr3:10126153 T/G cg16606324 chr3:10149918 C3orf24 0.57 11.19 0.4 1.16e-26 Alzheimer's disease; BRCA cis rs61931739 0.500 rs11053066 chr12:34185318 G/A cg06521331 chr12:34319734 NA -0.63 -11.57 -0.42 2.98e-28 Morning vs. evening chronotype; BRCA cis rs2070488 1.000 rs2070488 chr3:38442490 A/G cg24069376 chr3:38537580 EXOG -0.4 -11.37 -0.41 2.08e-27 Electrocardiographic conduction measures; BRCA cis rs17685 0.712 rs1637049 chr7:75729975 C/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.19 -0.31 1.4e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7818345 0.967 rs13258090 chr8:19285726 A/G cg11303988 chr8:19266685 CSGALNACT1 -0.32 -8.41 -0.32 2.62e-16 Language performance in older adults (adjusted for episodic memory); BRCA cis rs6546550 0.901 rs6736408 chr2:70137774 C/T cg02498382 chr2:70120550 SNRNP27 -0.53 -11.62 -0.42 1.93e-28 Prevalent atrial fibrillation; BRCA trans rs2048656 0.600 rs1976671 chr8:9679634 A/G cg06636001 chr8:8085503 FLJ10661 0.39 7.93 0.3 9.47e-15 Schizophrenia; BRCA cis rs2153535 0.541 rs9328477 chr6:8519109 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.48 0.38 8.08e-24 Motion sickness; BRCA cis rs78456975 1.000 rs11884854 chr2:1566154 A/G cg26248373 chr2:1572462 NA -0.48 -9.57 -0.35 2.24e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4919694 0.572 rs12243903 chr10:104906992 T/C cg04362960 chr10:104952993 NT5C2 0.72 12.66 0.45 6.05e-33 Arsenic metabolism; BRCA cis rs1577917 0.958 rs10944136 chr6:86448499 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.3 -7.81 -0.3 2.4e-14 Response to antipsychotic treatment; BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg20007245 chr22:24372913 LOC391322 0.76 18.56 0.59 8.28e-62 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs17685 0.753 rs12531559 chr7:75631697 C/T cg16489192 chr7:75678113 MDH2;STYXL1 0.38 8.51 0.32 1.25e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1506403 0.685 rs1994497 chr7:142816927 A/G cg22531018 chr7:142981779 TMEM139 0.45 8.59 0.32 6.48e-17 Cancer; BRCA cis rs2576037 0.562 rs612519 chr18:44379490 G/A cg19077165 chr18:44547161 KATNAL2 -0.58 -12.89 -0.45 5.75e-34 Personality dimensions; BRCA cis rs10851411 0.697 rs11636209 chr15:42788107 A/G cg21293051 chr15:42870591 STARD9 0.52 8.71 0.33 2.66e-17 Glucose homeostasis traits; BRCA trans rs911555 0.723 rs6575982 chr14:103862681 G/A cg17675199 chr6:35436792 RPL10A -0.29 -7.81 -0.3 2.37e-14 Intelligence (multi-trait analysis); BRCA cis rs644148 0.836 rs2571112 chr19:45000319 T/A cg15540054 chr19:45004280 ZNF180 -0.57 -12.3 -0.44 2.36e-31 Personality dimensions; BRCA cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg11644478 chr21:40555479 PSMG1 -0.54 -11.53 -0.42 4.36e-28 Menarche (age at onset); BRCA trans rs11098499 0.697 rs10016448 chr4:120298845 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA cis rs13191362 1.000 rs7764785 chr6:163009967 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg18230493 chr5:56204884 C5orf35 -0.61 -13.2 -0.46 2.42e-35 Initial pursuit acceleration; BRCA cis rs7267979 1.000 rs2424710 chr20:25283886 C/G cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.59 0.32 6.84e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg04267008 chr7:1944627 MAD1L1 0.45 10.13 0.37 1.89e-22 Bipolar disorder and schizophrenia; BRCA cis rs11585357 0.947 rs3003441 chr1:17611869 C/T cg19159961 chr1:17633534 PADI4 -0.5 -8.9 -0.33 5.6e-18 Hair shape; BRCA cis rs4555082 0.874 rs2816611 chr14:105722976 G/C cg13114125 chr14:105738426 BRF1 -0.48 -10.06 -0.37 3.29e-22 Mean platelet volume;Platelet distribution width; BRCA cis rs10504229 1.000 rs17216957 chr8:58179893 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs8141529 0.748 rs715531 chr22:29282679 A/G cg15103426 chr22:29168792 CCDC117 0.54 12.72 0.45 3.37e-33 Lymphocyte counts; BRCA cis rs7267979 0.844 rs8184820 chr20:25250577 C/T cg08601574 chr20:25228251 PYGB -0.4 -9.53 -0.35 3.15e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11676348 0.818 rs7425447 chr2:218980183 T/C cg00012203 chr2:219082015 ARPC2 -0.4 -7.84 -0.3 1.92e-14 Ulcerative colitis; BRCA cis rs2204008 0.640 rs11520199 chr12:38211026 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs2439831 0.702 rs8033995 chr15:44013509 G/C cg02155558 chr15:43621948 ADAL;LCMT2 0.69 12.29 0.44 2.67e-31 Lung cancer in ever smokers; BRCA cis rs6831352 0.734 rs2602856 chr4:100029145 C/A cg13256891 chr4:100009986 ADH5 0.46 9.58 0.35 2.16e-20 Alcohol dependence; BRCA cis rs17253792 0.545 rs17745459 chr14:56008549 T/A cg01858014 chr14:56050164 KTN1 -0.61 -7.83 -0.3 1.99e-14 Putamen volume; BRCA cis rs4665809 0.590 rs66477033 chr2:26472497 T/C cg26314531 chr2:26401878 FAM59B 0.94 16.39 0.54 1.24e-50 Gut microbiome composition (summer); BRCA cis rs7267979 1.000 rs422844 chr20:25445591 T/C cg08601574 chr20:25228251 PYGB 0.34 8.15 0.31 1.86e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs861020 1.000 rs7555285 chr1:209970355 C/G cg09163369 chr1:210001066 C1orf107 -0.49 -9.35 -0.35 1.41e-19 Orofacial clefts; BRCA cis rs7811142 1.000 rs11773661 chr7:100073069 G/C cg11814155 chr7:99998594 ZCWPW1 0.48 8.79 0.33 1.36e-17 Platelet count; BRCA cis rs312274 0.550 rs66578805 chr12:41264460 A/G cg17827154 chr12:41323612 CNTN1 -0.36 -9.0 -0.34 2.48e-18 Metabolite levels (X-11787); BRCA cis rs7666738 0.962 rs17550217 chr4:98999699 T/A cg17366294 chr4:99064904 C4orf37 0.54 11.57 0.42 2.97e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs6570726 0.935 rs369214 chr6:145856709 G/A cg23711669 chr6:146136114 FBXO30 0.64 14.89 0.51 2.93e-43 Lobe attachment (rater-scored or self-reported); BRCA trans rs11098499 0.908 rs9995234 chr4:120321827 A/G cg25214090 chr10:38739885 LOC399744 0.55 11.7 0.42 8.57e-29 Corneal astigmatism; BRCA cis rs2153535 0.580 rs2327058 chr6:8447018 C/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.7e-23 Motion sickness; BRCA cis rs977987 0.806 rs11640674 chr16:75394944 A/G cg03315344 chr16:75512273 CHST6 0.52 12.41 0.44 8.12e-32 Dupuytren's disease; BRCA cis rs7615952 0.641 rs7640158 chr3:125808011 G/A cg04553112 chr3:125709451 NA -0.55 -8.27 -0.31 7.6e-16 Blood pressure (smoking interaction); BRCA trans rs79976124 0.842 rs1548154 chr6:66624910 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.62 11.38 0.41 1.94e-27 Type 2 diabetes; BRCA cis rs782590 0.967 rs1975484 chr2:55803167 T/A cg18811423 chr2:55921094 PNPT1 0.71 22.76 0.67 1.91e-84 Metabolic syndrome; BRCA cis rs17270561 0.636 rs77343532 chr6:25828828 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 10.01 0.37 5.07e-22 Iron status biomarkers; BRCA cis rs2072499 0.932 rs3001790 chr1:156165290 T/G cg25208724 chr1:156163844 SLC25A44 1.06 34.16 0.8 2.58e-146 Testicular germ cell tumor; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg26608667 chr7:1196370 ZFAND2A 0.34 7.8 0.3 2.44e-14 Longevity;Endometriosis; BRCA trans rs9650657 0.803 rs13276026 chr8:10609955 G/A cg06636001 chr8:8085503 FLJ10661 -0.4 -8.46 -0.32 1.84e-16 Neuroticism; BRCA cis rs12497850 0.864 rs12493001 chr3:49181885 A/G cg06212747 chr3:49208901 KLHDC8B 0.52 10.78 0.39 5.39e-25 Parkinson's disease; BRCA cis rs6951245 0.935 rs61753396 chr7:1105372 A/G cg23708337 chr7:1209742 NA 0.64 8.74 0.33 2.05e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9381040 0.701 rs6933231 chr6:41163700 T/C cg09580153 chr6:41068724 NFYA;LOC221442 -0.38 -8.18 -0.31 1.5e-15 Alzheimer's disease (late onset); BRCA trans rs7819412 0.740 rs7844536 chr8:11034028 A/G cg15556689 chr8:8085844 FLJ10661 -0.35 -9.28 -0.34 2.57e-19 Triglycerides; BRCA cis rs992157 0.932 rs56109829 chr2:219149740 G/A cg00012203 chr2:219082015 ARPC2 0.62 12.94 0.46 3.55e-34 Colorectal cancer; BRCA cis rs12477438 1.000 rs1922624 chr2:99909958 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -11.03 -0.4 5.27e-26 Chronic sinus infection; BRCA cis rs2882667 0.690 rs7714455 chr5:138153970 T/G cg04439458 chr5:138467593 SIL1 0.33 8.31 0.31 5.8e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10411936 0.720 rs7252649 chr19:16582785 G/T cg10248733 chr19:16607483 C19orf44;CALR3 0.46 9.65 0.36 1.19e-20 White blood cell count;Multiple sclerosis; BRCA cis rs12971120 0.783 rs7229256 chr18:72169129 T/A cg14963724 chr18:72166303 CNDP2 -0.34 -9.44 -0.35 6.73e-20 Refractive error; BRCA cis rs13118159 0.527 rs1250119 chr4:1261336 G/A cg05025164 chr4:1340916 KIAA1530 -0.76 -14.93 -0.51 1.83e-43 Longevity; BRCA cis rs7085104 0.572 rs284856 chr10:104574329 A/T cg04362960 chr10:104952993 NT5C2 -0.34 -8.08 -0.3 3.17e-15 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs826838 0.967 rs4768330 chr12:39129399 T/C cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs6684514 1.000 rs12141236 chr1:156302575 A/C cg16558208 chr1:156270281 VHLL 0.35 8.08 0.3 3.34e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs7552404 1.000 rs28602663 chr1:76235355 C/T cg03433033 chr1:76189801 ACADM 0.67 14.21 0.49 5.11e-40 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9807989 0.501 rs11903946 chr2:103005330 A/G cg03938978 chr2:103052716 IL18RAP 0.29 8.42 0.32 2.39e-16 Asthma; BRCA cis rs6570726 1.000 rs455109 chr6:145872665 C/T cg23711669 chr6:146136114 FBXO30 0.64 14.85 0.51 4.32e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs9467773 0.572 rs62394558 chr6:26604650 G/A cg09904177 chr6:26538194 HMGN4 0.43 12.0 0.43 4.58e-30 Intelligence (multi-trait analysis); BRCA cis rs826838 0.802 rs10785619 chr12:38742897 T/A cg13010199 chr12:38710504 ALG10B 0.44 10.86 0.39 2.47e-25 Heart rate; BRCA cis rs7072216 0.770 rs1061123 chr10:100176997 A/G cg26618903 chr10:100175079 PYROXD2 -0.27 -8.11 -0.31 2.62e-15 Metabolite levels; BRCA cis rs6084875 0.733 rs6052854 chr20:4742399 A/G cg05143360 chr20:4741328 NA 0.36 8.13 0.31 2.27e-15 Systemic lupus erythematosus; BRCA cis rs7618501 0.633 rs11925192 chr3:50038664 G/A cg24308560 chr3:49941425 MST1R -0.39 -8.11 -0.31 2.66e-15 Intelligence (multi-trait analysis); BRCA cis rs595982 0.527 rs12151238 chr19:49368613 T/C cg15549821 chr19:49342101 PLEKHA4 -0.7 -11.51 -0.41 5.66e-28 Red cell distribution width; BRCA cis rs9463078 0.764 rs10948187 chr6:44921320 A/G cg25276700 chr6:44698697 NA 0.35 8.19 0.31 1.39e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1865721 1.000 rs72977888 chr18:73195250 C/T cg26385618 chr18:73139727 C18orf62 -0.39 -9.02 -0.34 2.26e-18 Intelligence; BRCA cis rs6952808 0.723 rs4721295 chr7:2036669 G/T cg04267008 chr7:1944627 MAD1L1 0.57 13.1 0.46 6.58e-35 Bipolar disorder and schizophrenia; BRCA cis rs7267979 0.933 rs2387887 chr20:25427081 G/T cg24626310 chr20:25276739 ABHD12;PYGB 0.33 9.24 0.34 3.64e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13046373 0.508 rs1507393 chr21:31992779 A/G cg24082983 chr21:31802169 KRTAP13-4 0.33 8.18 0.31 1.58e-15 HDL cholesterol; BRCA cis rs1372520 0.748 rs2737002 chr4:90753180 A/G cg15133208 chr4:90757351 SNCA -0.39 -7.92 -0.3 1.04e-14 Neuroticism; BRCA cis rs3858526 0.651 rs10838713 chr11:5858434 T/C cg13902645 chr11:5959945 NA -0.44 -8.58 -0.32 7.32e-17 DNA methylation (variation); BRCA cis rs1568889 1.000 rs35343234 chr11:28034379 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 12.98 0.46 2.38e-34 Bipolar disorder; BRCA cis rs9463078 0.838 rs1924662 chr6:45140332 T/A cg25276700 chr6:44698697 NA -0.36 -8.14 -0.31 2.04e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs4925386 0.625 rs3810550 chr20:60912117 C/T cg24112000 chr20:60950667 NA -0.45 -8.04 -0.3 4.5e-15 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs7666738 0.830 rs6840766 chr4:99016260 C/G cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs9394841 0.692 rs2395795 chr6:41802354 G/A cg08135965 chr6:41755394 TOMM6 0.47 7.82 0.3 2.15e-14 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs6433857 0.536 rs1971135 chr2:181351508 G/A cg23363182 chr2:181467187 NA -0.38 -7.93 -0.3 9.89e-15 Body mass index; BRCA cis rs6088590 0.965 rs6120730 chr20:33385102 G/C cg06115741 chr20:33292138 TP53INP2 0.52 11.69 0.42 9.91e-29 Coronary artery disease; BRCA cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg00031303 chr3:195681400 NA 0.49 9.48 0.35 4.92e-20 Pancreatic cancer; BRCA cis rs6138458 1.000 rs6114984 chr20:24976610 A/G cg26195577 chr20:24973756 C20orf3 1.03 28.97 0.75 1.65e-118 Blood protein levels; BRCA cis rs7666738 0.830 rs2903152 chr4:99067992 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.39 0.57 9.59e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2425143 1.000 rs7273668 chr20:34442731 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.61 -8.54 -0.32 9.92e-17 Blood protein levels; BRCA cis rs7552167 0.925 rs11249020 chr1:24512804 A/G cg01960748 chr1:24522592 NA -0.61 -10.08 -0.37 2.81e-22 Psoriasis vulgaris; BRCA cis rs7246657 0.943 rs4803229 chr19:37864682 T/G cg18154014 chr19:37997991 ZNF793 0.48 9.55 0.35 2.65e-20 Coronary artery calcification; BRCA cis rs2732480 0.517 rs2634676 chr12:48738236 A/G cg04545296 chr12:48745243 ZNF641 0.25 8.3 0.31 6.07e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs77972916 0.536 rs11679731 chr2:43589064 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.65 -10.4 -0.38 1.59e-23 Granulocyte percentage of myeloid white cells; BRCA cis rs7618915 0.501 rs2336149 chr3:52692124 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -11.99 -0.43 5.2e-30 Bipolar disorder; BRCA cis rs6952808 0.608 rs6461049 chr7:2017445 C/T cg21782813 chr7:2030301 MAD1L1 -0.34 -10.0 -0.37 5.7e-22 Bipolar disorder and schizophrenia; BRCA cis rs28735056 0.592 rs2277725 chr18:77694168 A/C cg20368463 chr18:77673604 PQLC1 -0.49 -12.12 -0.43 1.34e-30 Schizophrenia; BRCA cis rs801193 0.935 rs11772264 chr7:66176387 T/C cg18876405 chr7:65276391 NA 0.61 15.13 0.51 2.06e-44 Aortic root size; BRCA cis rs2276314 0.857 rs8097597 chr18:33619448 A/G cg05985134 chr18:33552581 C18orf21 0.63 12.3 0.44 2.32e-31 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs9486715 0.838 rs9400034 chr6:96954566 C/T cg06623918 chr6:96969491 KIAA0776 0.89 25.79 0.71 4.53e-101 Headache; BRCA cis rs67311347 1.000 rs4973994 chr3:40453024 T/C cg01475735 chr3:40494733 NA -0.43 -7.91 -0.3 1.13e-14 Renal cell carcinoma; BRCA cis rs11764590 0.724 rs1533829 chr7:2082841 A/G cg23422044 chr7:1970798 MAD1L1 -0.44 -9.4 -0.35 9.18e-20 Neuroticism; BRCA cis rs60843830 1.000 rs3791221 chr2:226933 A/G cg25945732 chr2:264204 ACP1;SH3YL1 0.78 18.35 0.59 9.61e-61 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg17063962 chr7:91808500 NA 0.53 12.21 0.43 6e-31 Breast cancer; BRCA trans rs10805346 0.501 rs4604059 chr4:10115065 C/T cg26043149 chr18:55253948 FECH -0.44 -10.32 -0.38 3.36e-23 Urate levels in overweight individuals;Urate levels in obese individuals; BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.05 23.03 0.67 6.4e-86 Platelet count; BRCA cis rs8180040 0.577 rs12493425 chr3:47176946 T/G cg16586182 chr3:47516702 SCAP -0.55 -12.23 -0.44 4.63e-31 Colorectal cancer; BRCA trans rs9329221 0.736 rs34381075 chr8:10243785 C/G cg06636001 chr8:8085503 FLJ10661 0.52 10.09 0.37 2.51e-22 Neuroticism; BRCA cis rs2304069 0.909 rs30831 chr5:149359053 C/T cg10852222 chr5:149380144 HMGXB3;TIGD6 -0.53 -8.33 -0.31 4.99e-16 HIV-1 control; BRCA trans rs1974653 0.781 rs175162 chr22:20113253 A/C cg20152630 chr19:46405944 MYPOP 0.37 8.33 0.31 5.01e-16 Schizophrenia; BRCA trans rs877282 0.685 rs56234340 chr10:781339 A/G cg22713356 chr15:30763199 NA 1.15 22.49 0.66 5.94e-83 Uric acid levels; BRCA cis rs1862618 0.853 rs832551 chr5:56180112 T/G cg18230493 chr5:56204884 C5orf35 -0.72 -14.12 -0.49 1.41e-39 Initial pursuit acceleration; BRCA cis rs3733585 0.604 rs73215003 chr4:10126317 C/G cg11266682 chr4:10021025 SLC2A9 -0.38 -9.48 -0.35 4.98e-20 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9486719 1.000 rs2499804 chr6:96861216 A/G cg06623918 chr6:96969491 KIAA0776 0.72 12.8 0.45 1.51e-33 Migraine;Coronary artery disease; BRCA cis rs1953600 1.000 rs2573346 chr10:81918041 G/A cg04850286 chr10:81895943 PLAC9 -0.35 -10.1 -0.37 2.35e-22 Sarcoidosis; BRCA cis rs1707322 1.000 rs785480 chr1:46492164 C/G cg03146154 chr1:46216737 IPP 0.44 9.8 0.36 3.15e-21 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11105298 0.891 rs11105287 chr12:89829470 C/T cg00757033 chr12:89920650 WDR51B 0.43 9.26 0.34 3.07e-19 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs9487051 1.000 rs1546723 chr6:109625879 G/A cg01475377 chr6:109611718 NA -0.51 -12.67 -0.45 5.32e-33 Reticulocyte fraction of red cells; BRCA cis rs2019137 0.560 rs7578633 chr2:113978650 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.6 12.51 0.44 2.94e-32 Lymphocyte counts; BRCA cis rs870825 0.929 rs72689254 chr4:185589941 C/T cg04058563 chr4:185651563 MLF1IP 0.69 11.72 0.42 7.1e-29 Blood protein levels; BRCA cis rs2304069 0.837 rs10041451 chr5:149385197 A/C cg12661370 chr5:149340060 SLC26A2 0.55 7.96 0.3 7.94e-15 HIV-1 control; BRCA cis rs67460515 0.892 rs11711413 chr3:160998910 C/G cg17135325 chr3:160939158 NMD3 0.39 7.82 0.3 2.14e-14 Parkinson's disease; BRCA cis rs7666738 0.830 rs13108422 chr4:99059267 G/A cg05340658 chr4:99064831 C4orf37 0.67 16.49 0.55 3.48e-51 Colonoscopy-negative controls vs population controls; BRCA cis rs11051970 0.879 rs2728682 chr12:32580193 G/A cg02745156 chr12:32552066 NA 0.27 8.9 0.33 5.93e-18 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10876993 0.890 rs2619441 chr12:58083015 C/A cg18357645 chr12:58087776 OS9 0.48 13.8 0.48 3.98e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs11718455 0.653 rs28533958 chr3:43974179 C/A cg08738300 chr3:44038990 NA 0.49 9.03 0.34 1.95e-18 Coronary artery disease; BRCA cis rs7666738 0.716 rs2865982 chr4:99031661 T/G cg03676636 chr4:99064102 C4orf37 0.21 7.99 0.3 6.19e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9814567 1.000 rs9856693 chr3:134306913 T/C cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.42 -0.61 2.35e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs1829883 0.835 rs10068675 chr5:98890617 C/G cg08333243 chr5:99726346 NA -0.36 -8.35 -0.31 4.27e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs10751667 0.666 rs11246357 chr11:963980 A/C ch.11.42038R chr11:967971 AP2A2 0.51 16.26 0.54 5.44e-50 Alzheimer's disease (late onset); BRCA cis rs910316 0.737 rs28687415 chr14:75495482 T/C cg23033748 chr14:75592666 NEK9 0.34 8.02 0.3 5e-15 Height; BRCA trans rs60843830 1.000 rs62114544 chr2:269679 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.75 0.5 1.34e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs7789940 1.000 rs17149161 chr7:75978229 C/A cg10167463 chr7:75959203 YWHAG -0.44 -8.86 -0.33 8.13e-18 Multiple sclerosis; BRCA trans rs4332037 0.552 rs11773627 chr7:2002733 A/G cg11693508 chr17:37793320 STARD3 0.53 10.18 0.37 1.14e-22 Bipolar disorder; BRCA trans rs1814175 0.529 rs10839396 chr11:49852406 G/T cg03929089 chr4:120376271 NA 0.79 17.0 0.56 9.17e-54 Height; BRCA cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg12386194 chr3:101231763 SENP7 0.46 9.79 0.36 3.64e-21 Colorectal cancer; BRCA cis rs1451375 1.000 rs2329342 chr7:50624971 A/G cg18232548 chr7:50535776 DDC -0.44 -10.23 -0.38 7.59e-23 Malaria; BRCA cis rs34779708 0.931 rs35388511 chr10:35296616 A/G cg03585969 chr10:35415529 CREM 0.49 10.21 0.37 9.07e-23 Inflammatory bowel disease;Crohn's disease; BRCA trans rs35110281 0.837 rs7279968 chr21:45077398 C/G cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.23 0.31 1.08e-15 Mean corpuscular volume; BRCA cis rs870825 0.616 rs4594761 chr4:185643002 A/C cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs67460515 0.892 rs35310734 chr3:160943209 T/G cg03342759 chr3:160939853 NMD3 -0.8 -18.84 -0.6 2.5e-63 Parkinson's disease; BRCA cis rs6570726 0.791 rs422099 chr6:145806936 C/T cg23711669 chr6:146136114 FBXO30 0.75 17.29 0.56 3.24e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs9790314 0.613 rs4679666 chr3:160629025 C/G cg03342759 chr3:160939853 NMD3 0.42 8.44 0.32 2.18e-16 Morning vs. evening chronotype; BRCA cis rs7098414 0.511 rs7898787 chr10:82156042 G/A cg01528321 chr10:82214614 TSPAN14 0.69 14.59 0.5 7.96e-42 Post bronchodilator FEV1; BRCA cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg21918786 chr6:109611834 NA 0.48 13.73 0.48 9.13e-38 Reticulocyte fraction of red cells; BRCA cis rs6952809 0.532 rs6956223 chr7:2431331 T/C cg05083358 chr7:2394359 EIF3B -0.51 -7.93 -0.3 1e-14 Multiple sclerosis; BRCA cis rs11123170 0.640 rs1015754 chr2:113967990 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.54 -9.77 -0.36 4.32e-21 Renal function-related traits (BUN); BRCA cis rs2012796 0.661 rs59969857 chr14:81841579 A/G cg02996355 chr14:81879375 NA 0.53 10.94 0.4 1.16e-25 Night sleep phenotypes; BRCA cis rs4975616 0.869 rs401681 chr5:1322087 C/T cg26373071 chr5:1325741 CLPTM1L 0.49 12.26 0.44 3.51e-31 Lung cancer; BRCA cis rs1577917 0.958 rs11756510 chr6:86699794 G/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.32 -7.9 -0.3 1.21e-14 Response to antipsychotic treatment; BRCA cis rs4363385 0.747 rs6668696 chr1:152964910 A/G cg24667326 chr1:152973720 SPRR3 -0.33 -9.33 -0.35 1.74e-19 Inflammatory skin disease; BRCA cis rs4819052 0.807 rs1075788 chr21:46666564 T/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.46 8.88 0.33 6.85e-18 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA trans rs6089829 0.889 rs6062773 chr20:61663262 G/C cg17470723 chr8:74884337 TCEB1 0.41 8.81 0.33 1.16e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs921968 0.565 rs755112 chr2:219606052 C/T cg02176678 chr2:219576539 TTLL4 -0.41 -11.05 -0.4 4.43e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs6951245 1.000 rs77760339 chr7:1083927 G/T cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.05e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg27170947 chr2:26402098 FAM59B -0.65 -11.62 -0.42 1.85e-28 Gut microbiome composition (summer); BRCA cis rs4665809 0.590 rs35656275 chr2:26494695 G/C cg27170947 chr2:26402098 FAM59B 0.97 16.99 0.56 1.05e-53 Gut microbiome composition (summer); BRCA cis rs9837602 0.935 rs4928149 chr3:99685686 A/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.61 -10.64 -0.39 1.95e-24 Breast cancer; BRCA cis rs7246657 0.639 rs3112434 chr19:38198148 G/T cg23950597 chr19:37808831 NA 0.51 8.58 0.32 7.23e-17 Coronary artery calcification; BRCA cis rs477692 0.673 rs10764889 chr10:131341521 G/A cg24747557 chr10:131355152 MGMT -0.37 -8.91 -0.33 5.46e-18 Response to temozolomide; BRCA cis rs6973256 0.865 rs4728295 chr7:133322680 A/T cg07491979 chr7:133331646 EXOC4 -0.38 -8.74 -0.33 2.05e-17 Intelligence (multi-trait analysis); BRCA cis rs13102973 0.899 rs4541577 chr4:135901087 G/T cg14419869 chr4:135874104 NA 0.47 9.55 0.35 2.68e-20 Subjective well-being; BRCA cis rs208520 1.000 rs12192261 chr6:66985268 A/G cg07460842 chr6:66804631 NA 0.88 14.23 0.49 4.1e-40 Exhaled nitric oxide output; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg11235426 chr6:292522 DUSP22 0.57 12.05 0.43 2.77e-30 Menopause (age at onset); BRCA cis rs12612619 0.557 rs1368888 chr2:27068577 G/C cg08802533 chr2:27073253 DPYSL5 -0.29 -7.82 -0.3 2.16e-14 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA trans rs877282 0.898 rs11253349 chr10:765897 C/G cg22713356 chr15:30763199 NA 1.3 24.11 0.69 7.71e-92 Uric acid levels; BRCA cis rs13315871 0.929 rs11720747 chr3:58267833 G/A cg20936604 chr3:58311152 NA -0.65 -8.03 -0.3 4.73e-15 Cholesterol, total; BRCA cis rs10193935 0.892 rs7574609 chr2:42388468 C/A cg27598129 chr2:42591480 NA -0.87 -14.49 -0.5 2.32e-41 Colonoscopy-negative controls vs population controls; BRCA cis rs1874326 0.545 rs4574789 chr7:138109427 C/A cg18008034 chr7:138118925 NA -0.45 -9.24 -0.34 3.74e-19 Quantitative traits; BRCA cis rs11690935 1.000 rs6757773 chr2:172549630 T/A cg13550731 chr2:172543902 DYNC1I2 0.93 31.76 0.78 1.53e-133 Schizophrenia; BRCA cis rs561341 1.000 rs550923 chr17:30327013 G/C cg23018236 chr17:30244563 NA -0.64 -10.29 -0.38 4.42e-23 Hip circumference adjusted for BMI; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg21664854 chr7:1097933 C7orf50;GPR146 0.37 8.11 0.31 2.55e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1451375 0.785 rs6593010 chr7:50629888 A/G cg18232548 chr7:50535776 DDC 0.41 9.89 0.36 1.48e-21 Malaria; BRCA cis rs763014 0.932 rs2384972 chr16:674424 G/A cg09256448 chr16:638327 NA 0.3 7.97 0.3 7.21e-15 Height; BRCA cis rs10256972 0.616 rs6463001 chr7:1108272 A/C cg03188948 chr7:1209495 NA 0.45 8.79 0.33 1.39e-17 Longevity;Endometriosis; BRCA cis rs10751667 0.666 rs4074233 chr11:977685 G/A cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs1577917 1.000 rs34281561 chr6:86701872 T/A cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.31 -7.83 -0.3 1.98e-14 Response to antipsychotic treatment; BRCA cis rs2762353 0.574 rs11756503 chr6:25710432 C/T cg03264133 chr6:25882463 NA 0.73 16.47 0.55 4.7e-51 Blood metabolite levels; BRCA cis rs7246657 0.551 rs28462002 chr19:37634462 A/G cg18154014 chr19:37997991 ZNF793 0.54 9.01 0.34 2.38e-18 Coronary artery calcification; BRCA cis rs651907 0.557 rs34947019 chr3:101532235 C/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.04 0.49 3.14e-39 Colorectal cancer; BRCA cis rs1005277 0.540 rs2474598 chr10:38430296 C/T cg00409905 chr10:38381863 ZNF37A 0.51 10.96 0.4 9.92e-26 Extrinsic epigenetic age acceleration; BRCA cis rs943466 0.614 rs4713677 chr6:33731225 C/G cg25922239 chr6:33757077 LEMD2 -0.33 -8.14 -0.31 2.06e-15 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs736408 0.677 rs2286798 chr3:52821177 G/T cg18404041 chr3:52824283 ITIH1 0.42 12.96 0.46 2.75e-34 Bipolar disorder; BRCA trans rs1005277 0.579 rs1985707 chr10:38434098 C/T cg23533926 chr12:111358616 MYL2 -0.41 -8.59 -0.32 6.59e-17 Extrinsic epigenetic age acceleration; BRCA cis rs4665809 0.941 rs3177055 chr2:26359315 G/A cg04944784 chr2:26401820 FAM59B -0.64 -10.13 -0.37 1.77e-22 Gut microbiome composition (summer); BRCA cis rs2072499 1.000 rs2253809 chr1:156172125 T/C cg06970220 chr1:156163860 SLC25A44 0.39 9.58 0.35 2.08e-20 Testicular germ cell tumor; BRCA trans rs66887589 0.616 rs7659403 chr4:120207254 T/A cg25214090 chr10:38739885 LOC399744 0.37 8.6 0.32 6.29e-17 Diastolic blood pressure; BRCA cis rs698833 0.828 rs6748528 chr2:44517752 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.52 10.63 0.39 2.07e-24 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs13191362 1.000 rs71567659 chr6:163001736 G/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.29 0.44 2.59e-31 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs769267 1.000 rs8103197 chr19:19443466 C/T cg20644253 chr19:19431407 KIAA0892;SF4 -0.6 -12.19 -0.43 7.39e-31 Tonsillectomy; BRCA cis rs12142240 0.698 rs58162700 chr1:46816659 T/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA trans rs6582630 0.502 rs11614397 chr12:38328163 C/T cg06521331 chr12:34319734 NA -0.49 -8.88 -0.33 6.67e-18 Drug-induced liver injury (flucloxacillin); BRCA cis rs17345786 0.798 rs4257518 chr3:101281709 C/T cg12386194 chr3:101231763 SENP7 -0.48 -9.99 -0.37 5.94e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs7945705 0.935 rs1883098 chr11:8890594 G/A cg12365402 chr11:9010492 NRIP3 -0.37 -8.67 -0.32 3.51e-17 Hemoglobin concentration; BRCA cis rs11105298 0.891 rs10858909 chr12:89935387 C/T cg08166232 chr12:89918718 WDR51B;GALNT4 -0.59 -9.77 -0.36 4.07e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs651907 0.513 rs34963630 chr3:101504817 C/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.51 13.19 0.46 2.74e-35 Colorectal cancer; BRCA cis rs7847628 0.587 rs1060817 chr9:123583192 A/G cg03808351 chr9:123631620 PHF19 0.61 12.65 0.45 6.8e-33 Birth weight; BRCA trans rs1005277 0.579 rs1621040 chr10:38497232 T/C cg17830980 chr10:43048298 ZNF37B -0.53 -12.9 -0.45 5.34e-34 Extrinsic epigenetic age acceleration; BRCA cis rs10465746 0.967 rs11576870 chr1:84333301 G/A cg10977910 chr1:84465055 TTLL7 0.5 10.17 0.37 1.29e-22 Obesity-related traits; BRCA trans rs2727020 0.634 rs11040331 chr11:49345726 T/C cg15704280 chr7:45808275 SEPT13 -0.71 -13.41 -0.47 2.65e-36 Coronary artery disease; BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.57 10.29 0.38 4.57e-23 Gut microbiome composition (summer); BRCA cis rs561341 1.000 rs72821971 chr17:30269343 T/G cg00745463 chr17:30367425 LRRC37B -0.62 -9.88 -0.36 1.64e-21 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.830 rs11944035 chr4:98931618 C/T cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA trans rs60843830 0.928 rs2306060 chr2:230912 A/C cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 14.19 0.49 6.4e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2282526 0.587 rs91424 chr21:44921161 A/G cg01579765 chr21:45077557 HSF2BP 0.33 8.35 0.31 4.28e-16 Mean corpuscular hemoglobin; BRCA cis rs8031584 0.958 rs7176569 chr15:31244495 G/T cg14829155 chr15:31115871 NA 0.43 9.93 0.37 1.03e-21 Huntington's disease progression; BRCA cis rs6138458 1.000 rs6106984 chr20:24977006 T/C cg06937882 chr20:24974362 C20orf3 -0.48 -9.46 -0.35 5.84e-20 Blood protein levels; BRCA cis rs11603020 0.950 rs28362951 chr11:57372526 A/G cg19752551 chr11:57585705 CTNND1 -0.43 -10.08 -0.37 2.88e-22 Blood protein levels; BRCA cis rs921968 0.643 rs2278530 chr2:219501133 G/A cg02176678 chr2:219576539 TTLL4 0.43 11.37 0.41 2.12e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs9733 0.566 rs112967224 chr1:150677263 G/A cg17724175 chr1:150552817 MCL1 0.25 8.19 0.31 1.45e-15 Tonsillectomy; BRCA cis rs7766436 0.767 rs13215709 chr6:22604121 A/G cg13666174 chr6:22585274 NA -0.36 -9.38 -0.35 1.16e-19 Coronary artery disease; BRCA cis rs9399137 0.507 rs4580893 chr6:135297662 G/A cg24558204 chr6:135376177 HBS1L 0.59 16.02 0.54 8.77e-49 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs7927771 0.864 rs755553 chr11:47432303 G/A cg20307385 chr11:47447363 PSMC3 0.4 9.08 0.34 1.39e-18 Subjective well-being; BRCA cis rs6540559 0.673 rs17015330 chr1:210012795 T/G cg22029157 chr1:209979665 IRF6 0.43 8.19 0.31 1.42e-15 Cleft lip with or without cleft palate; BRCA cis rs701145 0.643 rs7647694 chr3:153851535 C/G cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA cis rs7772486 0.774 rs2247571 chr6:146219533 T/A cg23711669 chr6:146136114 FBXO30 0.63 13.84 0.48 2.81e-38 Lobe attachment (rater-scored or self-reported); BRCA cis rs312274 0.609 rs1584096 chr12:41200529 C/A cg17827154 chr12:41323612 CNTN1 0.36 8.71 0.33 2.65e-17 Metabolite levels (X-11787); BRCA cis rs801193 0.844 rs7779971 chr7:66161790 T/C cg18876405 chr7:65276391 NA 0.62 15.35 0.52 1.6e-45 Aortic root size; BRCA cis rs912057 0.601 rs1294413 chr6:6739924 C/A cg06612196 chr6:6737390 NA 0.57 13.62 0.47 2.95e-37 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs6684514 1.000 rs12040868 chr1:156284803 G/T cg16558208 chr1:156270281 VHLL 0.37 8.39 0.32 3.05e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs6782228 0.675 rs9813845 chr3:128399623 G/C cg16766828 chr3:128327626 NA -0.41 -9.15 -0.34 7.41e-19 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs599083 0.530 rs667126 chr11:68177728 C/T cg01657329 chr11:68192670 LRP5 0.39 8.66 0.32 3.83e-17 Bone mineral density (spine); BRCA cis rs9513627 0.573 rs12431100 chr13:100184918 C/G cg15490075 chr13:100150979 NA -0.54 -9.67 -0.36 9.74e-21 Obesity-related traits; BRCA cis rs6582630 0.555 rs11182202 chr12:38476451 C/G cg26384229 chr12:38710491 ALG10B 0.74 17.6 0.57 7.83e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs873946 0.648 rs3793673 chr10:134547732 A/C cg26818010 chr10:134567672 INPP5A -0.71 -14.83 -0.51 5.36e-43 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs10504229 0.861 rs59873610 chr8:58172290 T/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.67 -0.36 9.51e-21 Developmental language disorder (linguistic errors); BRCA cis rs8062405 1.000 rs55991577 chr16:28843025 C/T cg09754948 chr16:28834200 ATXN2L 0.46 9.18 0.34 6.07e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs9443645 0.527 rs9361477 chr6:79710806 C/T cg18132916 chr6:79620363 NA -0.4 -8.09 -0.3 2.92e-15 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.752 rs12027622 chr1:46130252 A/C cg06784218 chr1:46089804 CCDC17 0.5 12.08 0.43 2.02e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2153535 0.580 rs9378554 chr6:8488468 C/T cg23788917 chr6:8435910 SLC35B3 0.49 10.69 0.39 1.17e-24 Motion sickness; BRCA cis rs881375 0.678 rs1930782 chr9:123687905 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.4 8.58 0.32 6.96e-17 Rheumatoid arthritis; BRCA cis rs270601 0.955 rs273911 chr5:131661526 C/G cg24060327 chr5:131705240 SLC22A5 -0.61 -11.54 -0.42 4.19e-28 Acylcarnitine levels; BRCA cis rs7666738 0.830 rs115712871 chr4:98954535 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.06e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.626 rs10854486 chr21:45118280 G/T cg01579765 chr21:45077557 HSF2BP -0.43 -11.79 -0.42 3.67e-29 Mean corpuscular volume; BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg24642844 chr7:1081250 C7orf50 -0.69 -13.1 -0.46 6.97e-35 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs11098499 0.588 rs2389874 chr4:120554991 A/G cg25214090 chr10:38739885 LOC399744 -0.39 -8.97 -0.33 3.15e-18 Corneal astigmatism; BRCA cis rs919433 1.000 rs112572902 chr2:198175179 G/C cg10820045 chr2:198174542 NA -0.46 -10.82 -0.39 3.67e-25 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1865721 0.771 rs7236311 chr18:73137450 A/G cg26385618 chr18:73139727 C18orf62 -0.43 -10.68 -0.39 1.36e-24 Intelligence; BRCA cis rs2153535 0.580 rs4960411 chr6:8438231 C/G cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.68e-18 Motion sickness; BRCA cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg00105475 chr2:10696890 NA 0.44 10.21 0.37 9.03e-23 Prostate cancer; BRCA cis rs7552404 0.960 rs4949877 chr1:76201668 C/G cg22875332 chr1:76189707 ACADM 0.69 14.76 0.5 1.23e-42 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs9858542 0.953 rs6766131 chr3:49538932 T/C cg21665057 chr3:196295764 WDR53;FBXO45 -0.39 -9.48 -0.35 4.76e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs6582630 0.519 rs8189461 chr12:38374870 G/T cg26384229 chr12:38710491 ALG10B 0.74 17.19 0.56 9.72e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs6964587 1.000 rs6970277 chr7:91680655 T/C cg01689657 chr7:91764605 CYP51A1 0.23 8.14 0.31 2.07e-15 Breast cancer; BRCA cis rs870825 0.587 rs35377170 chr4:185639728 T/C cg04058563 chr4:185651563 MLF1IP 0.78 17.43 0.57 5.93e-56 Blood protein levels; BRCA cis rs701145 0.585 rs1727884 chr3:153838368 A/C cg17054900 chr3:154042577 DHX36 0.54 9.04 0.34 1.82e-18 Coronary artery disease; BRCA trans rs11976180 1.000 rs2951353 chr7:143761116 G/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.46 -8.43 -0.32 2.37e-16 Obesity-related traits; BRCA cis rs919433 0.617 rs700643 chr2:198601370 A/G cg00792783 chr2:198669748 PLCL1 0.46 9.99 0.37 6.18e-22 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs2832191 0.791 rs2832186 chr21:30484151 A/C cg24692254 chr21:30365293 RNF160 -0.64 -17.58 -0.57 9.87e-57 Dental caries; BRCA cis rs9311474 0.659 rs1133415 chr3:52575831 G/A cg10802521 chr3:52805072 NEK4 -0.31 -8.48 -0.32 1.59e-16 Electroencephalogram traits; BRCA trans rs11098499 0.779 rs7674500 chr4:120303593 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.53 0.41 4.57e-28 Corneal astigmatism; BRCA trans rs11039798 0.764 rs7294013 chr11:48762416 G/A cg15704280 chr7:45808275 SEPT13 0.6 8.88 0.33 6.87e-18 Axial length; BRCA cis rs7618501 0.633 rs3774733 chr3:50037123 C/G cg05623727 chr3:50126028 RBM5 0.42 9.84 0.36 2.37e-21 Intelligence (multi-trait analysis); BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 0.62 9.95 0.37 8.58e-22 Renal function-related traits (BUN); BRCA cis rs11887277 0.507 rs1368892 chr2:27054551 A/G cg12368169 chr2:27073192 DPYSL5 -0.27 -8.06 -0.3 3.73e-15 Obesity-related traits; BRCA cis rs17376456 0.504 rs7702649 chr5:93065149 C/A cg25358565 chr5:93447407 FAM172A 0.69 11.95 0.43 7.36e-30 Diabetic retinopathy; BRCA cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg20933634 chr6:27740509 NA -0.48 -9.47 -0.35 5.12e-20 Parkinson's disease; BRCA cis rs7727544 0.716 rs10058655 chr5:131570896 A/T cg14196790 chr5:131705035 SLC22A5 0.42 10.59 0.39 3.01e-24 Blood metabolite levels; BRCA cis rs7811142 1.000 rs11766752 chr7:100073292 A/G cg00814883 chr7:100076585 TSC22D4 -0.52 -11.92 -0.43 1.04e-29 Platelet count; BRCA cis rs7044106 0.762 rs4837789 chr9:123426256 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 14.07 0.49 2.35e-39 Hip circumference adjusted for BMI; BRCA cis rs6062302 0.522 rs3761126 chr20:62252044 C/T cg03425785 chr20:62221387 GMEB2 0.51 8.25 0.31 8.77e-16 Glioblastoma; BRCA cis rs6582630 0.537 rs3942440 chr12:38459672 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.61 0.39 2.38e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs1862618 0.756 rs832548 chr5:56183637 G/C cg20203395 chr5:56204925 C5orf35 -0.5 -10.11 -0.37 2.13e-22 Initial pursuit acceleration; BRCA cis rs13392177 0.660 rs10932762 chr2:219076213 G/C cg00012203 chr2:219082015 ARPC2 -0.52 -10.51 -0.38 6.09e-24 Pyoderma gangrenosum in inflammatory bowel disease; BRCA cis rs11690935 0.921 rs7594711 chr2:172895637 T/G cg13550731 chr2:172543902 DYNC1I2 -0.9 -25.88 -0.72 1.55e-101 Schizophrenia; BRCA trans rs7824557 0.767 rs11250127 chr8:11170209 G/A cg08975724 chr8:8085496 FLJ10661 0.43 8.04 0.3 4.22e-15 Retinal vascular caliber; BRCA trans rs1005277 0.579 rs2472181 chr10:38386764 T/C cg17830980 chr10:43048298 ZNF37B -0.57 -13.98 -0.48 6.13e-39 Extrinsic epigenetic age acceleration; BRCA cis rs72781680 0.898 rs72796396 chr2:24178154 G/A cg08917208 chr2:24149416 ATAD2B 0.94 13.91 0.48 1.3e-38 Lymphocyte counts; BRCA cis rs6831352 0.703 rs3133152 chr4:100031721 C/G cg12011299 chr4:100065546 ADH4 0.42 10.52 0.38 5.65e-24 Alcohol dependence; BRCA cis rs2836974 0.555 rs35909862 chr21:40621158 G/A cg11644478 chr21:40555479 PSMG1 -0.68 -15.56 -0.52 1.65e-46 Cognitive function; BRCA cis rs9443645 0.869 rs10943609 chr6:79676328 A/T cg05283184 chr6:79620031 NA -0.41 -10.49 -0.38 7.56e-24 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.900 rs2531340 chr5:140131046 C/T cg11822812 chr5:140052017 DND1 -0.32 -8.69 -0.33 3.01e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs651907 0.535 rs13065944 chr3:101473088 G/A cg12386194 chr3:101231763 SENP7 0.46 9.88 0.36 1.6e-21 Colorectal cancer; BRCA cis rs477895 0.713 rs35095324 chr11:63948412 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.47 8.13 0.31 2.26e-15 Mean platelet volume; BRCA cis rs12986413 1.000 rs12459350 chr19:2176586 A/G cg09261902 chr19:2140048 AP3D1 0.39 10.2 0.37 9.68e-23 Height; BRCA cis rs1153858 1.000 rs7181167 chr15:45686236 C/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.49 0.41 6.44e-28 Homoarginine levels; BRCA cis rs6952808 0.723 rs11765550 chr7:2027324 G/A cg18279126 chr7:2041391 MAD1L1 0.37 8.02 0.3 5.24e-15 Bipolar disorder and schizophrenia; BRCA cis rs1552244 0.744 rs6763366 chr3:10033544 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 16.9 0.56 2.9e-53 Alzheimer's disease; BRCA cis rs1801251 1.000 rs13035829 chr2:233604487 A/T cg08000102 chr2:233561755 GIGYF2 0.63 14.03 0.49 3.74e-39 Coronary artery disease; BRCA cis rs4237845 0.537 rs10747786 chr12:58260601 G/T cg00677455 chr12:58241039 CTDSP2 0.63 15.75 0.53 1.84e-47 Intelligence (multi-trait analysis); BRCA cis rs6951245 0.529 rs76001997 chr7:1152615 C/T cg03188948 chr7:1209495 NA 0.68 11.55 0.42 3.6e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs812925 0.519 rs10199672 chr2:61627634 T/G cg15711740 chr2:61764176 XPO1 0.32 8.01 0.3 5.31e-15 Immature fraction of reticulocytes; BRCA cis rs17270561 0.553 rs9379784 chr6:25725506 A/G cg16482183 chr6:26056742 HIST1H1C 0.43 8.35 0.31 4.12e-16 Iron status biomarkers; BRCA cis rs7666738 0.830 rs11947578 chr4:98930462 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs2882667 0.598 rs10078179 chr5:138256099 G/C cg04439458 chr5:138467593 SIL1 -0.31 -7.83 -0.3 2.08e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6831352 0.918 rs2851249 chr4:100044822 T/C cg12011299 chr4:100065546 ADH4 0.51 11.78 0.42 4.02e-29 Alcohol dependence; BRCA cis rs514406 0.547 rs377808 chr1:53190359 T/G cg08859206 chr1:53392774 SCP2 -0.4 -7.83 -0.3 2.1e-14 Monocyte count; BRCA cis rs10504229 0.645 rs35142596 chr8:58128151 C/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs4563143 0.663 rs10406794 chr19:29228056 C/T cg12756686 chr19:29218302 NA 0.6 12.4 0.44 8.6e-32 Methadone dose in opioid dependence; BRCA cis rs7091068 0.707 rs829107 chr10:95418102 C/T cg20715218 chr10:95462985 C10orf4 -0.52 -7.91 -0.3 1.12e-14 Urinary tract infection frequency; BRCA cis rs7552404 0.691 rs5745449 chr1:76344711 A/T cg22875332 chr1:76189707 ACADM -0.54 -10.17 -0.37 1.32e-22 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs250677 0.687 rs2915809 chr5:148452111 A/T cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 7.27e-31 Breast cancer; BRCA cis rs4970988 0.501 rs11204713 chr1:150694623 T/A cg04414720 chr1:150670196 GOLPH3L 0.37 8.44 0.32 2.06e-16 Urate levels; BRCA cis rs634534 0.561 rs613924 chr11:65769295 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 9.82 0.36 2.67e-21 Sum eosinophil basophil counts;Eosinophil counts; BRCA cis rs6835098 0.961 rs2877748 chr4:174102397 G/A cg08422745 chr4:174089978 GALNT7 -0.75 -15.34 -0.52 1.81e-45 Dementia and core Alzheimer's disease neuropathologic changes; BRCA cis rs9527 0.545 rs7100369 chr10:104956218 C/A cg04362960 chr10:104952993 NT5C2 0.43 9.74 0.36 5.33e-21 Arsenic metabolism; BRCA cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg06212747 chr3:49208901 KLHDC8B 0.54 11.59 0.42 2.64e-28 Menarche (age at onset); BRCA cis rs4332037 0.575 rs55952733 chr7:2070680 G/A cg02743256 chr7:2109353 MAD1L1 -0.45 -8.4 -0.32 2.8e-16 Bipolar disorder; BRCA cis rs1153858 1.000 rs9788780 chr15:45685487 T/A cg14582100 chr15:45693742 SPATA5L1 0.36 11.54 0.42 4.09e-28 Homoarginine levels; BRCA cis rs780096 0.506 rs2288155 chr2:27714526 T/C cg12000995 chr2:27665139 KRTCAP3 -0.32 -7.94 -0.3 9.18e-15 Total body bone mineral density; BRCA cis rs12540874 0.698 rs3807566 chr7:50564204 G/T cg18232548 chr7:50535776 DDC -0.51 -12.65 -0.45 6.79e-33 Systemic sclerosis; BRCA cis rs13064411 0.542 rs2399477 chr3:113222998 A/G cg18753928 chr3:113234510 CCDC52 -0.45 -9.69 -0.36 8.07e-21 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs7246657 1.000 rs1823061 chr19:37800626 G/A cg23950597 chr19:37808831 NA -0.63 -10.94 -0.4 1.15e-25 Coronary artery calcification; BRCA cis rs16866061 1.000 rs72972378 chr2:225372562 A/G cg12698349 chr2:225449008 CUL3 0.77 21.11 0.64 1.92e-75 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs832540 0.519 rs6450411 chr5:56265771 A/G cg18230493 chr5:56204884 C5orf35 -0.4 -8.06 -0.3 3.86e-15 Coronary artery disease; BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg04944784 chr2:26401820 FAM59B 0.98 14.38 0.49 7.93e-41 Gut microbiome composition (summer); BRCA cis rs733592 0.894 rs886589 chr12:48477197 C/T cg24011408 chr12:48396354 COL2A1 -0.45 -9.72 -0.36 6.38e-21 Plateletcrit; BRCA cis rs7772486 0.790 rs2253880 chr6:146200774 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.08 0.56 3.5e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs911555 0.547 rs8006994 chr14:103841296 C/T cg12935359 chr14:103987150 CKB -0.5 -10.68 -0.39 1.31e-24 Intelligence (multi-trait analysis); BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg23982607 chr1:1823379 GNB1 0.34 8.24 0.31 1.01e-15 Body mass index; BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg13628971 chr7:2884303 GNA12 0.45 9.01 0.34 2.42e-18 Height; BRCA cis rs7552404 1.000 rs72686191 chr1:76218319 G/T cg03433033 chr1:76189801 ACADM 0.75 16.43 0.55 7.14e-51 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6089829 0.926 rs7273917 chr20:61665975 G/A cg03213289 chr20:61660250 NA 0.62 16.18 0.54 1.29e-49 Prostate cancer (SNP x SNP interaction); BRCA cis rs4363385 0.747 rs1413849 chr1:152970233 C/A cg24667326 chr1:152973720 SPRR3 -0.34 -9.36 -0.35 1.36e-19 Inflammatory skin disease; BRCA cis rs6570726 0.791 rs436156 chr6:145874873 A/G cg05347473 chr6:146136440 FBXO30 0.43 8.55 0.32 8.98e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg07308232 chr7:1071921 C7orf50 -0.5 -10.57 -0.39 3.71e-24 Longevity;Endometriosis; BRCA trans rs3858145 0.588 rs736535 chr10:70043916 G/A cg04882175 chr6:131122610 NA -0.34 -7.85 -0.3 1.74e-14 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs782590 0.870 rs2586950 chr2:55868966 T/G cg18811423 chr2:55921094 PNPT1 0.68 20.03 0.62 1.19e-69 Metabolic syndrome; BRCA cis rs4363385 0.747 rs1984198 chr1:152958584 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.78 -0.33 1.54e-17 Inflammatory skin disease; BRCA cis rs9457247 0.663 rs2237274 chr6:167442995 C/G cg07741184 chr6:167504864 NA 0.27 7.96 0.3 7.76e-15 Crohn's disease; BRCA cis rs3806843 1.000 rs11167609 chr5:140200426 T/G cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.82 -0.36 2.67e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs1030877 0.960 rs3792049 chr2:105901908 A/C cg02079111 chr2:105885981 TGFBRAP1 -0.66 -15.75 -0.53 1.72e-47 Obesity-related traits; BRCA cis rs372883 0.638 rs371432 chr21:30710876 G/A cg08807101 chr21:30365312 RNF160 -0.39 -8.3 -0.31 5.97e-16 Pancreatic cancer; BRCA cis rs8031584 0.918 rs34693097 chr15:31253984 A/G cg14829155 chr15:31115871 NA -0.42 -9.67 -0.36 9.95e-21 Huntington's disease progression; BRCA cis rs7103648 0.669 rs7927445 chr11:47780754 G/T cg03711944 chr11:47377212 SPI1 -0.39 -9.25 -0.34 3.28e-19 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs2153535 0.580 rs9393021 chr6:8466123 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs9300255 0.602 rs1617434 chr12:123649486 A/G cg00376283 chr12:123451042 ABCB9 0.51 11.17 0.4 1.36e-26 Neutrophil percentage of white cells; BRCA cis rs3733585 0.577 rs28558552 chr4:9964913 G/A cg11266682 chr4:10021025 SLC2A9 -0.38 -9.93 -0.37 1.02e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg20603222 chr7:1096387 C7orf50;GPR146 -0.37 -7.83 -0.3 2.02e-14 Longevity;Endometriosis; BRCA cis rs6424115 0.679 rs2294495 chr1:24075876 C/T cg10978503 chr1:24200527 CNR2 -0.43 -9.48 -0.35 5.04e-20 Immature fraction of reticulocytes; BRCA cis rs7267979 1.000 rs7019 chr20:25278278 C/T cg08601574 chr20:25228251 PYGB 0.37 8.89 0.33 6.14e-18 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17376456 0.877 rs12716456 chr5:93397557 A/G cg25358565 chr5:93447407 FAM172A 1.16 18.84 0.6 2.51e-63 Diabetic retinopathy; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg22907277 chr7:1156413 C7orf50 0.6 9.01 0.34 2.28e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2404602 0.610 rs28823285 chr15:77050395 T/C cg23625390 chr15:77176239 SCAPER -0.55 -13.89 -0.48 1.61e-38 Blood metabolite levels; BRCA cis rs9467711 0.606 rs13203358 chr6:26590578 A/T cg12826209 chr6:26865740 GUSBL1 0.64 8.39 0.31 3.22e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs9858542 1.000 rs11130213 chr3:49712297 C/T cg03060546 chr3:49711283 APEH -0.59 -11.93 -0.43 9.23e-30 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs1973993 0.691 rs553785 chr1:96895325 G/A cg10631902 chr5:14652156 NA 0.59 21.2 0.64 6.24e-76 Weight; BRCA cis rs4664304 0.620 rs4665125 chr2:160714314 C/G cg18514922 chr2:160761262 LY75 0.34 7.84 0.3 1.94e-14 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9486719 1.000 rs2142653 chr6:96871520 C/A cg06623918 chr6:96969491 KIAA0776 0.74 13.05 0.46 1.17e-34 Migraine;Coronary artery disease; BRCA cis rs4319547 1.000 rs1392236 chr12:123074890 C/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -10.15 -0.37 1.52e-22 Body mass index; BRCA trans rs3857536 0.544 rs208453 chr6:66906841 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.56 -10.39 -0.38 1.75e-23 Blood trace element (Cu levels); BRCA cis rs2075371 0.796 rs10954440 chr7:134005657 C/T cg02659138 chr7:134003124 SLC35B4 0.4 11.58 0.42 2.86e-28 Mean platelet volume; BRCA cis rs13256369 1.000 rs7004438 chr8:8574379 C/T cg18904891 chr8:8559673 CLDN23 0.59 11.5 0.41 5.78e-28 Obesity-related traits; BRCA trans rs3960554 0.808 rs4728587 chr7:75803132 C/T cg19862616 chr7:65841803 NCRNA00174 0.59 11.91 0.43 1.13e-29 Eotaxin levels; BRCA cis rs10782582 0.593 rs4646960 chr1:76211103 C/A cg03433033 chr1:76189801 ACADM -0.49 -10.34 -0.38 2.72e-23 Daytime sleep phenotypes; BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.98 18.24 0.59 3.77e-60 Platelet count; BRCA cis rs637571 0.522 rs542332 chr11:65744421 C/T cg02427764 chr11:65769310 BANF1;EIF1AD 0.6 13.7 0.48 1.26e-37 Eosinophil percentage of white cells; BRCA cis rs7772486 0.790 rs11760 chr6:146205973 G/T cg05347473 chr6:146136440 FBXO30 0.41 7.97 0.3 7.18e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs6964587 1.000 rs10228334 chr7:91713972 C/T cg17063962 chr7:91808500 NA 0.54 12.71 0.45 3.83e-33 Breast cancer; BRCA cis rs35306767 0.715 rs11253539 chr10:1011347 G/A cg18964960 chr10:1102726 WDR37 0.59 8.0 0.3 5.81e-15 Eosinophil percentage of granulocytes; BRCA cis rs2249625 0.874 rs2463745 chr6:72876135 A/G cg18830697 chr6:72922368 RIMS1 -0.37 -8.0 -0.3 5.84e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs67311347 1.000 rs6801185 chr3:40505060 C/T cg09455208 chr3:40491958 NA -0.48 -11.9 -0.43 1.25e-29 Renal cell carcinoma; BRCA cis rs7586879 0.639 rs7580081 chr2:25097072 G/C cg01884057 chr2:25150051 NA 0.32 8.45 0.32 2.01e-16 Body mass index; BRCA cis rs6460942 0.915 rs10488158 chr7:12508894 C/T cg06484146 chr7:12443880 VWDE -0.74 -10.35 -0.38 2.64e-23 Coronary artery disease; BRCA cis rs7618915 0.571 rs34115864 chr3:52612178 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 9.84 0.36 2.36e-21 Bipolar disorder; BRCA cis rs534126 0.778 rs6464540 chr7:142954903 G/A cg21852589 chr7:142981689 TMEM139 0.44 10.06 0.37 3.23e-22 Cancer; BRCA trans rs11098499 0.954 rs35091806 chr4:120325529 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs4481887 1.000 rs4244174 chr1:248467956 A/G cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA cis rs7811142 0.830 rs75636500 chr7:99947657 C/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 17.99 0.58 7.86e-59 Platelet count; BRCA cis rs2836974 0.863 rs6517519 chr21:40540245 A/G cg11644478 chr21:40555479 PSMG1 0.82 18.77 0.6 6.19e-63 Cognitive function; BRCA cis rs9790314 1.000 rs163328 chr3:161073599 A/G cg03342759 chr3:160939853 NMD3 -0.54 -11.63 -0.42 1.67e-28 Morning vs. evening chronotype; BRCA cis rs6088580 0.668 rs1205337 chr20:32926041 T/A cg06115741 chr20:33292138 TP53INP2 -0.39 -8.54 -0.32 9.69e-17 Glomerular filtration rate (creatinine); BRCA cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg22535103 chr8:58192502 C8orf71 -0.46 -9.04 -0.34 1.87e-18 Developmental language disorder (linguistic errors); BRCA cis rs61931739 0.500 rs11053269 chr12:34545307 A/G cg06521331 chr12:34319734 NA -0.52 -10.29 -0.38 4.53e-23 Morning vs. evening chronotype; BRCA cis rs7011049 1.000 rs72640849 chr8:53836430 A/T cg26025543 chr8:53854495 NA 0.55 9.76 0.36 4.4e-21 Systolic blood pressure; BRCA trans rs2204008 0.744 rs11168870 chr12:37973333 A/G cg06521331 chr12:34319734 NA -0.54 -9.66 -0.36 1.07e-20 Bladder cancer; BRCA cis rs6981523 0.553 rs11989369 chr8:11055385 A/G cg21775007 chr8:11205619 TDH 0.46 8.48 0.32 1.51e-16 Neuroticism; BRCA cis rs7552404 0.924 rs1146588 chr1:76229787 C/G cg03433033 chr1:76189801 ACADM 0.73 18.53 0.59 1.16e-61 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs13191362 1.000 rs13195226 chr6:163006421 A/G cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.36 0.31 4.07e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7552404 0.961 rs17587071 chr1:76225083 A/C cg22875332 chr1:76189707 ACADM 0.69 14.74 0.5 1.58e-42 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs950169 0.544 rs62021193 chr15:85170583 C/G cg17173187 chr15:85201210 NMB 0.42 8.85 0.33 8.83e-18 Schizophrenia; BRCA cis rs11098499 0.954 rs1480931 chr4:120395809 G/T cg09307838 chr4:120376055 NA 0.72 15.18 0.51 1.14e-44 Corneal astigmatism; BRCA cis rs2153535 0.601 rs9502715 chr6:8455709 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.2 0.49 5.6e-40 Motion sickness; BRCA cis rs9811920 0.609 rs6809988 chr3:99656615 A/G cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -8.05 -0.3 3.94e-15 Axial length; BRCA cis rs10479542 0.549 rs4376229 chr5:179042971 A/G cg05457628 chr5:178986728 RUFY1 0.53 11.94 0.43 8.53e-30 Lung cancer; BRCA cis rs6842047 0.809 rs3087505 chr4:187179486 A/G cg09526685 chr4:187126073 CYP4V2 0.89 10.08 0.37 2.77e-22 Blood protein levels; BRCA cis rs3733585 0.648 rs7378305 chr4:9954893 C/T cg11266682 chr4:10021025 SLC2A9 -0.39 -10.34 -0.38 2.7e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6910061 0.956 rs9468419 chr6:11102576 T/C cg27233058 chr6:11094804 LOC221710 0.53 9.36 0.35 1.33e-19 Diabetic kidney disease; BRCA cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.59 14.38 0.49 8.14e-41 Colorectal cancer; BRCA cis rs4727027 0.625 rs75129390 chr7:148846775 T/A cg23583168 chr7:148888333 NA -0.75 -17.46 -0.57 3.96e-56 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs651907 0.535 rs34161138 chr3:101510388 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.42 0.47 2.35e-36 Colorectal cancer; BRCA cis rs2836950 0.520 rs8130240 chr21:40538108 G/A cg06238570 chr21:40685208 BRWD1 -0.39 -7.88 -0.3 1.47e-14 Menarche (age at onset); BRCA cis rs2549003 1.000 rs3846732 chr5:131816087 T/C cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.5e-34 Asthma (sex interaction); BRCA cis rs9393692 1.000 rs9393692 chr6:26276650 A/G cg05868516 chr6:26286170 HIST1H4H 0.43 8.87 0.33 7.16e-18 Educational attainment; BRCA cis rs7552404 0.696 rs12140121 chr1:76455001 A/G cg10523679 chr1:76189770 ACADM 0.62 10.83 0.39 3.39e-25 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs11229555 0.645 rs12290089 chr11:58176849 A/G cg15696309 chr11:58395628 NA -0.45 -9.77 -0.36 4.3e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1865760 0.663 rs9467656 chr6:25993559 G/A cg16482183 chr6:26056742 HIST1H1C 0.49 10.4 0.38 1.69e-23 Height; BRCA cis rs1707322 0.752 rs10789467 chr1:46118745 C/G cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs1994135 0.647 rs67243558 chr12:33695383 T/C cg26384229 chr12:38710491 ALG10B 0.52 10.93 0.4 1.33e-25 Resting heart rate; BRCA cis rs7493 0.755 rs17166859 chr7:94995519 T/C cg17330251 chr7:94953956 PON1 -0.41 -8.58 -0.32 7.06e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4919087 0.892 rs10786319 chr10:99008951 T/C cg25902810 chr10:99078978 FRAT1 0.37 8.08 0.3 3.25e-15 Monocyte count; BRCA cis rs7584330 0.554 rs80151891 chr2:238398826 G/T cg14458575 chr2:238380390 NA 0.54 8.64 0.32 4.4e-17 Prostate cancer; BRCA cis rs9325144 0.581 rs2730929 chr12:38942739 T/C cg13010199 chr12:38710504 ALG10B -0.36 -7.83 -0.3 2.1e-14 Morning vs. evening chronotype; BRCA cis rs829883 0.932 rs249840 chr12:98871993 T/C cg25150519 chr12:98850993 NA 0.58 11.84 0.42 2.14e-29 Colorectal adenoma (advanced); BRCA trans rs2204008 0.543 rs2387018 chr12:38065638 C/T cg06521331 chr12:34319734 NA -0.51 -9.4 -0.35 9.41e-20 Bladder cancer; BRCA cis rs7568458 0.846 rs1078004 chr2:85769711 C/G cg17127132 chr2:85788382 GGCX 0.36 8.11 0.31 2.51e-15 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs7267979 0.932 rs2387891 chr20:25470328 C/G cg08601574 chr20:25228251 PYGB 0.35 8.47 0.32 1.74e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs1129187 1.000 rs1129187 chr6:42932200 G/T cg09436375 chr6:42928200 GNMT -0.3 -10.99 -0.4 7.32e-26 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs10504229 0.871 rs10504227 chr8:58162005 G/A cg24829409 chr8:58192753 C8orf71 -0.53 -11.02 -0.4 5.69e-26 Developmental language disorder (linguistic errors); BRCA trans rs61931739 0.517 rs4931771 chr12:34044557 G/A cg26384229 chr12:38710491 ALG10B 0.68 14.28 0.49 2.34e-40 Morning vs. evening chronotype; BRCA cis rs9814567 1.000 rs35718987 chr3:134272783 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.29 0.31 6.45e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs17023223 0.508 rs12096448 chr1:119683390 G/A cg05756136 chr1:119680316 WARS2 -0.41 -7.81 -0.3 2.31e-14 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs933688 0.938 rs12110065 chr5:90718474 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.89 19.86 0.62 9.79e-69 Smoking behavior; BRCA cis rs2835872 0.869 rs73203821 chr21:39046744 C/T cg06728970 chr21:39037746 KCNJ6 -0.34 -8.29 -0.31 6.72e-16 Electroencephalographic traits in alcoholism; BRCA cis rs6952808 0.501 rs4721429 chr7:2171704 T/C cg08027265 chr7:2291960 NA -0.37 -8.52 -0.32 1.14e-16 Bipolar disorder and schizophrenia; BRCA cis rs7827545 1.000 rs6578232 chr8:135565690 G/A cg17885191 chr8:135476712 NA 0.47 9.19 0.34 5.3e-19 Hypertension (SNP x SNP interaction); BRCA cis rs5771069 0.896 rs137862 chr22:50446550 C/A cg03721641 chr22:50451245 IL17REL 0.32 9.91 0.37 1.24e-21 Ulcerative colitis; BRCA cis rs875971 0.505 rs1723275 chr7:65504633 G/C cg18876405 chr7:65276391 NA -0.7 -17.96 -0.58 1.05e-58 Aortic root size; BRCA cis rs35110281 0.682 rs162379 chr21:44925334 A/G cg21573476 chr21:45109991 RRP1B 0.3 7.83 0.3 2e-14 Mean corpuscular volume; BRCA trans rs75804782 0.521 rs72993044 chr2:239397949 C/T cg01134436 chr17:81009848 B3GNTL1 0.69 8.75 0.33 1.91e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs514406 0.861 rs7513052 chr1:53241360 C/T cg16325326 chr1:53192061 ZYG11B -0.65 -16.23 -0.54 7.41e-50 Monocyte count; BRCA cis rs9399135 0.967 rs1590975 chr6:135352088 C/T cg24558204 chr6:135376177 HBS1L 0.43 11.91 0.43 1.11e-29 Red blood cell count; BRCA cis rs8114671 0.562 rs6088655 chr20:33527838 A/G cg24642439 chr20:33292090 TP53INP2 0.42 8.99 0.34 2.82e-18 Height; BRCA cis rs10206020 0.885 rs6720797 chr2:1574340 T/C cg01028140 chr2:1542097 TPO -0.57 -12.03 -0.43 3.57e-30 IgG glycosylation; BRCA trans rs6582630 0.519 rs11181294 chr12:38312787 C/T cg06521331 chr12:34319734 NA -0.48 -8.78 -0.33 1.47e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs1008375 0.932 rs6857678 chr4:17696964 A/T cg04450456 chr4:17643702 FAM184B 0.33 9.61 0.36 1.68e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 0.938 rs4665822 chr2:26312555 C/G cg26314531 chr2:26401878 FAM59B -0.66 -11.25 -0.41 6.5e-27 Gut microbiome composition (summer); BRCA cis rs2964802 0.505 rs13159419 chr5:10824302 C/A cg14521931 chr5:10832172 NA -0.58 -12.7 -0.45 4.12e-33 Major depressive disorder;Recurrent major depressive disorder; BRCA cis rs11051970 0.704 rs2733694 chr12:32555230 A/G cg02745156 chr12:32552066 NA 0.25 8.49 0.32 1.48e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10504229 0.610 rs7011877 chr8:58147181 C/T cg24829409 chr8:58192753 C8orf71 -0.42 -8.54 -0.32 9.73e-17 Developmental language disorder (linguistic errors); BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg15112475 chr7:1198522 ZFAND2A -0.51 -11.28 -0.41 5.09e-27 Longevity;Endometriosis; BRCA cis rs72772090 0.539 rs11738810 chr5:96119055 T/C cg17330273 chr5:96107758 CAST;ERAP1 -0.58 -12.18 -0.43 7.64e-31 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs780096 0.526 rs780106 chr2:27681598 A/C cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs11971779 0.688 rs1862880 chr7:139020100 T/C cg07862535 chr7:139043722 LUC7L2 0.44 11.62 0.42 1.81e-28 Diisocyanate-induced asthma; BRCA cis rs10504229 1.000 rs73609747 chr8:58189104 G/C cg24829409 chr8:58192753 C8orf71 -0.6 -12.52 -0.44 2.53e-32 Developmental language disorder (linguistic errors); BRCA cis rs7178424 1.000 rs11635977 chr15:62370484 T/C cg00456672 chr15:62358751 C2CD4A -0.35 -8.2 -0.31 1.29e-15 Height; BRCA cis rs1862618 0.853 rs832553 chr5:56114786 A/G cg20203395 chr5:56204925 C5orf35 -0.51 -10.71 -0.39 1.02e-24 Initial pursuit acceleration; BRCA cis rs798554 0.567 rs1182192 chr7:2869274 G/A cg19717773 chr7:2847554 GNA12 -0.43 -9.56 -0.35 2.42e-20 Height; BRCA cis rs295140 0.546 rs842830 chr2:201131124 C/T cg23649088 chr2:200775458 C2orf69 -0.42 -9.06 -0.34 1.58e-18 QT interval; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.01 19.61 0.61 2.24e-67 Platelet count; BRCA cis rs9649213 0.537 rs35997266 chr7:97965566 T/C cg21770322 chr7:97807741 LMTK2 0.45 11.92 0.43 9.83e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs7264396 0.623 rs2425127 chr20:34332037 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.16 -0.43 9.24e-31 Total cholesterol levels; BRCA cis rs9463078 0.774 rs9296457 chr6:45264687 A/G cg25276700 chr6:44698697 NA -0.36 -8.03 -0.3 4.54e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2251381 0.778 rs2471947 chr21:30534219 G/T cg08807101 chr21:30365312 RNF160 0.57 12.35 0.44 1.46e-31 Selective IgA deficiency; BRCA cis rs9325144 0.555 rs7960411 chr12:38703019 A/G cg26384229 chr12:38710491 ALG10B -0.56 -13.64 -0.47 2.21e-37 Morning vs. evening chronotype; BRCA cis rs2842992 0.724 rs15982 chr6:160199687 T/C cg16489826 chr6:160211363 TCP1;MRPL18 0.62 14.36 0.49 9.66e-41 Age-related macular degeneration (geographic atrophy); BRCA cis rs847577 0.630 rs6967926 chr7:97715088 C/T cg21770322 chr7:97807741 LMTK2 0.66 19.85 0.62 1.18e-68 Breast cancer; BRCA cis rs2243480 1.000 rs58669269 chr7:65951953 T/C cg18252515 chr7:66147081 NA -1.07 -15.92 -0.53 2.69e-48 Diabetic kidney disease; BRCA cis rs17685 0.784 rs1637043 chr7:75699099 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.38 -8.47 -0.32 1.74e-16 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs4689388 0.889 rs13128674 chr4:6294517 C/T cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7953249 0.514 rs1169312 chr12:121441461 G/T cg02403541 chr12:121454288 C12orf43 0.53 9.98 0.37 7.06e-22 Invasive epithelial ovarian cancer;High-grade serous ovarian cancer;Chronic obstructive pulmonary disease-related biomarkers;N-glycan levels;Serous invasive ovarian cancer;Epithelial ovarian cancer; BRCA cis rs9640161 0.830 rs3757423 chr7:150067714 A/G cg21361702 chr7:150065534 REPIN1 -0.5 -10.39 -0.38 1.73e-23 Blood protein levels;Circulating chemerin levels; BRCA cis rs910873 0.505 rs6087607 chr20:33197489 A/G cg16810054 chr20:33298113 TP53INP2 -0.49 -10.52 -0.38 5.51e-24 Melanoma; BRCA cis rs7640424 0.620 rs34910554 chr3:107816733 C/T cg09227934 chr3:107805635 CD47 -0.43 -8.14 -0.31 2.08e-15 Body mass index; BRCA trans rs6951245 1.000 rs77760339 chr7:1083927 G/T cg13565492 chr6:43139072 SRF -0.79 -10.98 -0.4 8.18e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7829975 0.606 rs891570 chr8:8794454 G/A cg15556689 chr8:8085844 FLJ10661 -0.42 -11.61 -0.42 2.16e-28 Mood instability; BRCA cis rs11920090 0.932 rs2292620 chr3:170724036 T/C cg09710316 chr3:170744871 SLC2A2 0.55 9.6 0.35 1.8e-20 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs6964587 0.900 rs7783674 chr7:91784212 T/A cg01689657 chr7:91764605 CYP51A1 0.23 8.15 0.31 1.89e-15 Breast cancer; BRCA cis rs12477438 0.748 rs4851185 chr2:99666497 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.56 -0.52 1.55e-46 Chronic sinus infection; BRCA cis rs12908161 0.960 rs17599989 chr15:85285536 A/G cg12863693 chr15:85201151 NMB 0.57 12.39 0.44 9.96e-32 Schizophrenia; BRCA cis rs853679 0.517 rs9380057 chr6:28104634 G/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.14 -0.31 2.1e-15 Depression; BRCA cis rs1552244 1.000 rs113771705 chr3:10075983 T/C cg10729496 chr3:10149963 C3orf24 0.48 9.0 0.34 2.49e-18 Alzheimer's disease; BRCA cis rs6952808 0.510 rs13227554 chr7:2048220 G/C cg14004847 chr7:1930337 MAD1L1 0.46 9.96 0.37 7.96e-22 Bipolar disorder and schizophrenia; BRCA trans rs783540 0.934 rs36109438 chr15:83264459 T/G cg18393722 chr15:85113863 UBE2QP1 -0.26 -8.2 -0.31 1.37e-15 Schizophrenia; BRCA cis rs798554 0.660 rs2527694 chr7:2858240 T/C cg04166393 chr7:2884313 GNA12 0.39 8.46 0.32 1.8e-16 Height; BRCA cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg19077165 chr18:44547161 KATNAL2 -0.6 -13.45 -0.47 1.66e-36 Personality dimensions; BRCA cis rs13046373 0.505 rs2832962 chr21:32008332 T/C cg06468780 chr21:31798236 KRTAP13-3 0.34 8.29 0.31 6.81e-16 HDL cholesterol; BRCA cis rs881375 0.967 rs1548783 chr9:123658639 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.21 0.31 1.2e-15 Rheumatoid arthritis; BRCA cis rs7100689 0.646 rs2039757 chr10:82078868 C/A cg01528321 chr10:82214614 TSPAN14 0.81 17.1 0.56 2.94e-54 Post bronchodilator FEV1; BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg16606324 chr3:10149918 C3orf24 0.55 10.85 0.39 2.84e-25 Alzheimer's disease; BRCA cis rs6598955 0.671 rs11579354 chr1:26604071 T/G cg00852783 chr1:26633632 UBXN11 -0.46 -8.09 -0.3 2.9e-15 Obesity-related traits; BRCA cis rs4819052 0.851 rs8127834 chr21:46696109 G/A cg11663144 chr21:46675770 NA -0.62 -14.84 -0.51 5.12e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3858526 0.606 rs10838883 chr11:5952147 G/A cg25319279 chr11:5960081 NA 0.48 10.46 0.38 9.97e-24 DNA methylation (variation); BRCA cis rs919433 0.617 rs13018267 chr2:198545592 G/C cg00792783 chr2:198669748 PLCL1 -0.45 -9.75 -0.36 4.88e-21 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs11676348 0.818 rs6436031 chr2:218979259 T/C cg00012203 chr2:219082015 ARPC2 -0.42 -8.13 -0.31 2.2e-15 Ulcerative colitis; BRCA cis rs1865760 0.566 rs4529296 chr6:26083135 C/G cg17691542 chr6:26056736 HIST1H1C 0.55 11.91 0.43 1.13e-29 Height; BRCA trans rs60843830 1.000 rs17713396 chr2:227201 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 0.63 13.45 0.47 1.78e-36 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs4660306 0.961 rs4660868 chr1:45986497 A/G cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.96 -0.3 8.12e-15 Homocysteine levels; BRCA cis rs672059 1.000 rs1760624 chr1:183158552 C/A ch.1.3577855R chr1:183094577 LAMC1 0.37 8.56 0.32 8.26e-17 Hypertriglyceridemia; BRCA cis rs7903847 0.642 rs11814021 chr10:99158386 A/G cg20016023 chr10:99160130 RRP12 -0.26 -8.32 -0.31 5.39e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs6952808 0.689 rs79950306 chr7:2022063 C/G cg18279126 chr7:2041391 MAD1L1 0.38 7.92 0.3 1.06e-14 Bipolar disorder and schizophrenia; BRCA cis rs10848704 0.956 rs10848703 chr12:2882250 C/T cg19995117 chr12:2880862 NA 0.47 11.26 0.41 5.99e-27 Quantitative traits; BRCA cis rs796364 0.906 rs281789 chr2:200780698 T/G cg23649088 chr2:200775458 C2orf69 0.6 8.94 0.33 4.14e-18 Schizophrenia; BRCA cis rs312273 0.806 rs10879396 chr12:41340667 A/G cg17827154 chr12:41323612 CNTN1 -0.43 -11.15 -0.4 1.63e-26 Bipolar disorder; BRCA cis rs775227 0.574 rs36108475 chr3:113038406 C/T cg18753928 chr3:113234510 CCDC52 -0.57 -9.49 -0.35 4.41e-20 Dental caries; BRCA trans rs637571 0.565 rs633800 chr11:65638719 G/A cg17712092 chr4:129076599 LARP1B -0.6 -13.95 -0.48 8.5e-39 Eosinophil percentage of white cells; BRCA cis rs13256369 0.802 rs13281933 chr8:8562665 C/A cg06671706 chr8:8559999 CLDN23 0.45 8.76 0.33 1.75e-17 Obesity-related traits; BRCA cis rs9733 0.628 rs7540874 chr1:150702663 A/C cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA trans rs61931739 0.534 rs814669 chr12:34102459 C/T cg26384229 chr12:38710491 ALG10B 0.57 12.26 0.44 3.38e-31 Morning vs. evening chronotype; BRCA cis rs2882667 0.690 rs10044401 chr5:138237557 A/G cg04439458 chr5:138467593 SIL1 -0.34 -8.36 -0.31 4.05e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10501293 0.917 rs10838003 chr11:43071988 T/A cg03447554 chr11:43094025 NA 0.45 8.6 0.32 6.32e-17 Cognitive performance; BRCA cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg05340658 chr4:99064831 C4orf37 0.56 9.89 0.36 1.53e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2303759 0.874 rs8108669 chr19:49845895 C/T cg22590775 chr19:49891494 CCDC155 0.47 8.27 0.31 7.62e-16 Multiple sclerosis; BRCA cis rs2180341 1.000 rs9401950 chr6:127655485 C/T cg27446573 chr6:127587934 RNF146 0.9 21.24 0.64 3.9e-76 Breast cancer; BRCA cis rs4642101 0.793 rs6799179 chr3:12829095 A/C cg24848339 chr3:12840334 CAND2 0.46 12.16 0.43 9.6e-31 QRS complex (12-leadsum); BRCA cis rs9814567 0.896 rs6799110 chr3:134206749 T/C cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.91 -0.3 1.15e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11102986 0.607 rs10776909 chr9:137288746 T/C cg00753924 chr9:137298813 RXRA -0.59 -9.84 -0.36 2.23e-21 Intelligence; BRCA cis rs9644630 1.000 rs9644631 chr8:19370830 C/T cg01280390 chr8:19363452 CSGALNACT1 0.4 9.26 0.34 2.99e-19 Oropharynx cancer; BRCA cis rs778371 0.676 rs7560115 chr2:233709465 T/G cg08000102 chr2:233561755 GIGYF2 -0.77 -16.3 -0.54 3.3e-50 Schizophrenia; BRCA cis rs11711311 1.000 rs3806641 chr3:113465761 T/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.42 11.24 0.41 7.45e-27 IgG glycosylation; BRCA cis rs35306767 0.715 rs17221463 chr10:1038040 T/C cg26597838 chr10:835615 NA 0.93 14.38 0.49 7.94e-41 Eosinophil percentage of granulocytes; BRCA cis rs1862618 0.802 rs4389648 chr5:56103602 A/G cg03609598 chr5:56110824 MAP3K1 -0.47 -7.93 -0.3 9.55e-15 Initial pursuit acceleration; BRCA cis rs7246657 0.943 rs7255996 chr19:37971699 G/A cg23950597 chr19:37808831 NA -0.62 -11.59 -0.42 2.48e-28 Coronary artery calcification; BRCA cis rs11252926 0.674 rs11598550 chr10:504778 A/C cg18196295 chr10:418757 DIP2C -0.5 -11.27 -0.41 5.44e-27 Psychosis in Alzheimer's disease; BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg08888203 chr3:10149979 C3orf24 0.62 12.78 0.45 1.79e-33 Alzheimer's disease; BRCA cis rs9921222 0.500 rs8046256 chr16:393948 C/T cg12437481 chr16:420112 MRPL28 -0.56 -11.32 -0.41 3.44e-27 Bone mineral density (spine);Bone mineral density; BRCA cis rs758324 0.648 rs31473 chr5:131404446 A/T cg06307176 chr5:131281290 NA -0.38 -8.23 -0.31 1.09e-15 Alzheimer's disease in APOE e4- carriers; BRCA cis rs698833 0.962 rs786406 chr2:44735953 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.49 -9.61 -0.36 1.64e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs13102973 0.829 rs13126756 chr4:135900185 G/A cg14419869 chr4:135874104 NA 0.47 9.47 0.35 5.45e-20 Subjective well-being; BRCA cis rs9368481 0.546 rs12664610 chr6:26885031 G/A cg18867708 chr6:26865862 GUSBL1 0.42 8.24 0.31 9.97e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs9309711 0.772 rs9309715 chr2:3492318 C/G cg16153549 chr2:3496821 NA 0.43 10.13 0.37 1.85e-22 Neurofibrillary tangles; BRCA cis rs1499972 0.941 rs62264766 chr3:117641227 A/G cg07612923 chr3:117604196 NA 0.6 8.1 0.31 2.82e-15 Schizophrenia; BRCA cis rs6545883 0.894 rs4672423 chr2:61435275 C/T cg15711740 chr2:61764176 XPO1 0.52 13.21 0.46 2.17e-35 Tuberculosis; BRCA trans rs11098499 0.691 rs10010355 chr4:120261043 A/G cg25214090 chr10:38739885 LOC399744 0.42 9.85 0.36 2.11e-21 Corneal astigmatism; BRCA cis rs10504229 0.683 rs16921829 chr8:58110950 A/G cg20607798 chr8:58055168 NA 0.47 8.26 0.31 8.19e-16 Developmental language disorder (linguistic errors); BRCA cis rs7772486 0.875 rs11755334 chr6:146399297 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.69 -0.33 2.93e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.903 rs11253485 chr10:919362 C/T cg20503657 chr10:835505 NA 1.04 18.24 0.59 3.93e-60 Eosinophil percentage of granulocytes; BRCA cis rs13082711 0.911 rs923940 chr3:27459341 C/G cg02860705 chr3:27208620 NA 0.51 9.99 0.37 6.32e-22 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs7829975 0.688 rs13270194 chr8:8378102 T/C cg06636001 chr8:8085503 FLJ10661 0.68 15.58 0.52 1.22e-46 Mood instability; BRCA cis rs6952808 0.689 rs58227534 chr7:2046328 A/G cg05863683 chr7:1912471 MAD1L1 0.37 8.3 0.31 6.18e-16 Bipolar disorder and schizophrenia; BRCA cis rs17125944 0.505 rs2295826 chr14:53174923 C/T cg13660082 chr14:53194042 PSMC6 0.54 8.67 0.32 3.58e-17 Alzheimer's disease (late onset); BRCA cis rs35146811 0.844 rs13223792 chr7:99675659 T/G cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.34 7.95 0.3 8.64e-15 Coronary artery disease; BRCA cis rs72772090 0.522 rs111977797 chr5:96016167 G/A cg17330273 chr5:96107758 CAST;ERAP1 -0.59 -8.12 -0.31 2.41e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs113835537 0.529 rs74869459 chr11:66296569 T/C cg24851651 chr11:66362959 CCS 0.47 8.82 0.33 1.1e-17 Airway imaging phenotypes; BRCA cis rs7584330 0.868 rs58057291 chr2:238395479 T/A cg14458575 chr2:238380390 NA 0.59 13.46 0.47 1.55e-36 Prostate cancer; BRCA cis rs2153535 0.580 rs9379210 chr6:8461928 C/G cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.89e-18 Motion sickness; BRCA trans rs853679 0.546 rs71537572 chr6:27970715 T/C cg01620082 chr3:125678407 NA -0.98 -11.27 -0.41 5.59e-27 Depression; BRCA cis rs7646881 0.812 rs59192661 chr3:158459027 T/C cg19483011 chr3:158453295 NA -0.45 -7.95 -0.3 8.22e-15 Tetralogy of Fallot; BRCA cis rs3892630 0.824 rs7247264 chr19:33239846 T/G cg22980127 chr19:33182716 NUDT19 0.9 17.6 0.57 7.68e-57 Red blood cell traits; BRCA cis rs3806843 1.000 rs1548699 chr5:140164918 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.42 -9.53 -0.35 3.1e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs68170813 0.559 rs9641378 chr7:106868003 T/C cg02696742 chr7:106810147 HBP1 -0.51 -8.51 -0.32 1.28e-16 Coronary artery disease; BRCA cis rs6495367 1.000 rs4778882 chr15:79382019 A/G cg17916960 chr15:79447300 NA 0.38 9.07 0.34 1.4e-18 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs72772090 0.710 rs17400741 chr5:96066576 C/G cg24982541 chr5:96078678 CAST -0.46 -7.94 -0.3 9.29e-15 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs911555 0.617 rs7156036 chr14:103908142 A/G cg12935359 chr14:103987150 CKB 0.65 15.04 0.51 5.37e-44 Intelligence (multi-trait analysis); BRCA cis rs9388451 1.000 rs9388451 chr6:126090377 A/G cg05901451 chr6:126070800 HEY2 -0.69 -19.23 -0.61 2.23e-65 Brugada syndrome; BRCA cis rs2625529 0.652 rs2929525 chr15:72287856 G/A cg16672083 chr15:72433130 SENP8 0.7 16.71 0.55 2.89e-52 Red blood cell count; BRCA cis rs270601 0.690 rs162904 chr5:131595784 C/T cg11843238 chr5:131593191 PDLIM4 -0.4 -9.82 -0.36 2.63e-21 Acylcarnitine levels; BRCA cis rs7917772 0.503 rs11191342 chr10:104344450 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.61 18.28 0.59 2.39e-60 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs312274 0.609 rs10879259 chr12:41222390 A/G cg17827154 chr12:41323612 CNTN1 0.38 9.29 0.35 2.32e-19 Metabolite levels (X-11787); BRCA cis rs61931739 0.500 rs11836198 chr12:34552782 T/C cg06521331 chr12:34319734 NA -0.52 -10.27 -0.38 5.25e-23 Morning vs. evening chronotype; BRCA cis rs7927771 0.864 rs11604680 chr11:47457539 A/G cg20307385 chr11:47447363 PSMC3 -0.45 -9.02 -0.34 2.13e-18 Subjective well-being; BRCA cis rs61990749 0.500 rs8011337 chr14:78272626 T/G cg02301378 chr14:78227641 SNW1;C14orf178 0.67 10.47 0.38 8.51e-24 Fibroblast growth factor basic levels; BRCA cis rs2066819 1.000 rs11171803 chr12:56718422 T/C cg26734620 chr12:56694298 CS 0.9 10.37 0.38 2.09e-23 Psoriasis vulgaris; BRCA cis rs7917772 0.503 rs7087665 chr10:104282418 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.08 0.62 6.44e-70 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs61931739 0.500 rs7955247 chr12:34126580 G/A cg26384229 chr12:38710491 ALG10B 0.66 13.9 0.48 1.49e-38 Morning vs. evening chronotype; BRCA cis rs12586317 0.548 rs12590678 chr14:35602956 C/T cg16230307 chr14:35515116 FAM177A1 0.67 13.99 0.48 5.68e-39 Psoriasis; BRCA trans rs11165623 0.564 rs9887887 chr1:96996930 A/G cg10631902 chr5:14652156 NA -0.43 -12.06 -0.43 2.43e-30 Hip circumference;Waist circumference; BRCA cis rs2760061 0.626 rs672907 chr1:228120345 G/A cg02753203 chr1:228287806 NA -0.6 -13.03 -0.46 1.4e-34 Diastolic blood pressure; BRCA cis rs4853012 0.941 rs78128123 chr2:74347525 C/T cg05890377 chr2:74357713 NA 0.57 11.76 0.42 4.9e-29 Gestational age at birth (maternal effect); BRCA trans rs4332037 0.538 rs4721164 chr7:1932629 C/G cg11693508 chr17:37793320 STARD3 0.42 8.82 0.33 1.11e-17 Bipolar disorder; BRCA cis rs701145 0.585 rs7612886 chr3:153821176 T/A cg17054900 chr3:154042577 DHX36 0.53 9.04 0.34 1.88e-18 Coronary artery disease; BRCA cis rs2303759 0.918 rs10405465 chr19:49869298 C/T cg22307029 chr19:49891270 CCDC155 0.5 9.18 0.34 6.11e-19 Multiple sclerosis; BRCA cis rs9457247 0.602 rs10484530 chr6:167461562 C/T cg07741184 chr6:167504864 NA 0.36 10.37 0.38 2.2e-23 Crohn's disease; BRCA cis rs10089 1.000 rs7713877 chr5:127428825 G/T cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.68 16.31 0.54 2.98e-50 Ileal carcinoids; BRCA cis rs10845606 0.781 rs7972866 chr12:12828320 C/T cg04607235 chr12:12878440 APOLD1 -0.44 -7.94 -0.3 9.34e-15 Systemic lupus erythematosus; BRCA cis rs13191362 1.000 rs34398656 chr6:162999612 G/T cg06582575 chr6:163149167 PACRG;PARK2 0.71 11.32 0.41 3.49e-27 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs875971 1.000 rs11974264 chr7:65647582 C/G cg11764359 chr7:65958608 NA -0.8 -19.12 -0.6 8.59e-65 Aortic root size; BRCA cis rs7590368 1.000 rs2884289 chr2:10959724 G/A cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.02e-15 Educational attainment (years of education); BRCA trans rs1493916 0.905 rs4799727 chr18:31393095 T/G cg15819921 chr19:927150 ARID3A -0.52 -9.64 -0.36 1.26e-20 Life satisfaction; BRCA cis rs7043114 0.525 rs7047089 chr9:95117980 C/T cg14631576 chr9:95140430 CENPP -0.34 -8.33 -0.31 4.92e-16 Height; BRCA cis rs2731664 0.792 rs163199 chr5:176890067 A/G cg23176889 chr5:176863531 GRK6 -0.62 -17.03 -0.56 6.51e-54 Intelligence (multi-trait analysis); BRCA cis rs9814567 1.000 rs6802654 chr3:134217072 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -9.02 -0.34 2.13e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs11098499 0.738 rs72918577 chr4:120326701 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.62 0.45 8.93e-33 Corneal astigmatism; BRCA cis rs7520050 0.966 rs6661910 chr1:46290632 A/T cg24296786 chr1:45957014 TESK2 0.43 9.77 0.36 4.07e-21 Red blood cell count;Reticulocyte count; BRCA trans rs62103177 0.608 rs4442895 chr18:77826399 C/G cg05926928 chr17:57297772 GDPD1 -0.66 -9.83 -0.36 2.49e-21 Opioid sensitivity; BRCA cis rs1862618 0.853 rs252909 chr5:56121131 T/C cg22800045 chr5:56110881 MAP3K1 0.67 12.82 0.45 1.22e-33 Initial pursuit acceleration; BRCA cis rs1218582 0.772 rs6669791 chr1:154845484 G/T cg03351412 chr1:154909251 PMVK 0.6 13.88 0.48 1.72e-38 Prostate cancer; BRCA cis rs881375 0.967 rs1014529 chr9:123684943 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.32 0.31 5.44e-16 Rheumatoid arthritis; BRCA cis rs7618501 0.501 rs35275715 chr3:49959148 A/G cg14019146 chr3:50243930 SLC38A3 -0.4 -9.85 -0.36 2.18e-21 Intelligence (multi-trait analysis); BRCA cis rs3892630 0.620 rs10413279 chr19:33182746 A/G cg22980127 chr19:33182716 NUDT19 0.97 23.7 0.68 1.39e-89 Red blood cell traits; BRCA cis rs8180040 0.966 rs11705957 chr3:47443262 T/G cg16586182 chr3:47516702 SCAP 0.65 15.04 0.51 5.26e-44 Colorectal cancer; BRCA cis rs899997 0.773 rs62010525 chr15:78968310 C/G cg04896959 chr15:78267971 NA -0.47 -9.57 -0.35 2.36e-20 Coronary artery disease or large artery stroke; BRCA cis rs12612619 0.704 rs7602823 chr2:27309406 G/A cg00617064 chr2:27272375 NA 0.33 8.41 0.32 2.66e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs7267979 0.808 rs84816 chr20:25459919 G/A cg24626310 chr20:25276739 ABHD12;PYGB 0.31 8.58 0.32 7.29e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs17685 0.753 rs1637037 chr7:75692927 C/T cg16489192 chr7:75678113 MDH2;STYXL1 -0.4 -8.96 -0.33 3.61e-18 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs10876993 0.928 rs1689587 chr12:58075398 A/G cg18357645 chr12:58087776 OS9 0.48 13.82 0.48 3.37e-38 Celiac disease or Rheumatoid arthritis; BRCA cis rs9309711 0.666 rs6767 chr2:3483205 C/T cg15541040 chr2:3486749 NA -0.46 -10.21 -0.37 8.86e-23 Neurofibrillary tangles; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 16.37 0.54 1.4e-50 Platelet count; BRCA trans rs61931739 0.500 rs11053211 chr12:34464334 T/C cg13010199 chr12:38710504 ALG10B 0.42 8.95 0.33 3.69e-18 Morning vs. evening chronotype; BRCA trans rs7647973 0.710 rs7629322 chr3:49621994 C/T cg21659725 chr3:3221576 CRBN -0.53 -9.35 -0.35 1.44e-19 Menarche (age at onset); BRCA cis rs694739 0.628 rs508168 chr11:64135435 G/A cg02228329 chr11:64053129 BAD;GPR137 0.53 11.84 0.42 2.27e-29 Alopecia areata;Crohn's disease;Psoriasis vulgaris; BRCA cis rs10504229 1.000 rs67237174 chr8:58175776 T/C cg14926445 chr8:58193284 C8orf71 -0.45 -8.53 -0.32 1.02e-16 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs7696686 chr4:98938445 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs7611218 chr3:10063960 T/C cg00166722 chr3:10149974 C3orf24 0.6 12.19 0.43 6.74e-31 Alzheimer's disease; BRCA cis rs798554 0.836 rs2260230 chr7:2822986 T/A cg19346786 chr7:2764209 NA -0.34 -9.98 -0.37 6.97e-22 Height; BRCA cis rs67311347 1.000 rs17078813 chr3:40434162 C/T cg09455208 chr3:40491958 NA 0.52 11.84 0.42 2.27e-29 Renal cell carcinoma; BRCA cis rs4689388 0.926 rs11725494 chr4:6293855 C/T cg25554036 chr4:6271136 WFS1 0.38 9.01 0.34 2.43e-18 Type 2 diabetes and other traits;Type 2 diabetes; BRCA trans rs3780486 0.846 rs3824458 chr9:33144809 C/T cg04842962 chr6:43655489 MRPS18A 1.11 36.98 0.83 6.17e-161 IgG glycosylation; BRCA cis rs10492096 0.947 rs61918022 chr12:6614521 C/T cg13857086 chr12:6580257 VAMP1 0.43 8.43 0.32 2.35e-16 Hip geometry; BRCA trans rs11039798 0.544 rs114343057 chr11:48558172 C/T cg15704280 chr7:45808275 SEPT13 0.53 8.97 0.33 3.33e-18 Axial length; BRCA cis rs2180341 0.781 rs877102 chr6:127587086 T/C cg27446573 chr6:127587934 RNF146 0.69 14.84 0.51 4.96e-43 Breast cancer; BRCA cis rs875971 0.662 rs448725 chr7:65514628 A/G cg11764359 chr7:65958608 NA 0.75 17.49 0.57 2.93e-56 Aortic root size; BRCA cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg11189052 chr15:85197271 WDR73 0.44 8.94 0.33 4.28e-18 Schizophrenia; BRCA cis rs7582180 0.700 rs4640404 chr2:100980523 C/T cg14675211 chr2:100938903 LONRF2 -0.42 -9.53 -0.35 3.2e-20 Intelligence (multi-trait analysis); BRCA cis rs4148883 0.651 rs2851301 chr4:100010127 C/T cg12011299 chr4:100065546 ADH4 0.42 10.89 0.4 1.89e-25 Alcohol dependence; BRCA cis rs483180 0.511 rs496195 chr1:120207182 A/G cg19096424 chr1:120255104 PHGDH -0.42 -9.3 -0.35 2.12e-19 Macular telangiectasia type 2; BRCA cis rs3617 0.573 rs9880978 chr3:52923251 C/G cg11645453 chr3:52864694 ITIH4 0.36 9.46 0.35 5.87e-20 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs3806843 0.705 rs2530230 chr5:140088131 G/A cg11822812 chr5:140052017 DND1 -0.31 -8.52 -0.32 1.15e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs6582630 0.519 rs11181998 chr12:38439970 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.57 0.39 3.5e-24 Drug-induced liver injury (flucloxacillin); BRCA cis rs9470366 0.527 rs4711456 chr6:36632482 C/T cg08179530 chr6:36648295 CDKN1A -0.55 -12.53 -0.44 2.31e-32 QRS duration; BRCA cis rs3733585 0.648 rs13103497 chr4:9979262 A/G cg11266682 chr4:10021025 SLC2A9 0.37 9.7 0.36 7.66e-21 Cleft plate (environmental tobacco smoke interaction); BRCA trans rs561341 0.941 rs8081016 chr17:30331751 A/G cg27661571 chr11:113659931 NA -0.74 -11.34 -0.41 2.71e-27 Hip circumference adjusted for BMI; BRCA cis rs11585357 0.895 rs2501795 chr1:17633499 A/G cg08277548 chr1:17600880 PADI3 -0.57 -10.0 -0.37 5.59e-22 Hair shape; BRCA cis rs9649213 0.593 rs3801264 chr7:97950620 A/G cg01877450 chr7:97915802 BRI3 -0.39 -8.98 -0.33 3.1e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs6066835 1.000 rs6066831 chr20:47354131 C/A cg18078177 chr20:47281410 PREX1 0.69 8.6 0.32 6.2e-17 Multiple myeloma; BRCA cis rs4845875 0.626 rs1889292 chr1:11840943 T/C cg24844545 chr1:11908347 NPPA 0.33 8.25 0.31 9.01e-16 Midregional pro atrial natriuretic peptide levels; BRCA cis rs9486719 1.000 rs12208449 chr6:96903253 A/G cg06623918 chr6:96969491 KIAA0776 0.71 12.68 0.45 5.23e-33 Migraine;Coronary artery disease; BRCA cis rs13191362 1.000 rs13193282 chr6:163015442 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 13.04 0.46 1.24e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs7246657 0.653 rs10402050 chr19:37688958 A/T cg18154014 chr19:37997991 ZNF793 0.56 9.34 0.35 1.63e-19 Coronary artery calcification; BRCA cis rs6570726 0.902 rs373321 chr6:145854150 T/A cg23711669 chr6:146136114 FBXO30 0.64 14.99 0.51 9.22e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618501 0.602 rs2240327 chr3:50113034 C/T cg05623727 chr3:50126028 RBM5 0.41 9.93 0.37 1.05e-21 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.591 rs86138 chr21:44932398 G/A cg04455712 chr21:45112962 RRP1B 0.36 9.31 0.35 1.98e-19 Mean corpuscular volume; BRCA cis rs3858526 0.874 rs10838879 chr11:5950169 C/T cg25319279 chr11:5960081 NA -0.43 -8.41 -0.32 2.62e-16 DNA methylation (variation); BRCA cis rs2153535 0.580 rs718502 chr6:8527400 T/C cg21535247 chr6:8435926 SLC35B3 0.41 9.34 0.35 1.54e-19 Motion sickness; BRCA cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg07606381 chr6:8435919 SLC35B3 0.63 13.54 0.47 6.48e-37 Motion sickness; BRCA cis rs2204008 0.537 rs11170128 chr12:38006632 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.84 0.55 5.89e-53 Bladder cancer; BRCA trans rs11098499 0.954 rs6849561 chr4:120409694 C/G cg19731845 chr4:166199412 KLHL2;GK3P -0.36 -8.05 -0.3 3.93e-15 Corneal astigmatism; BRCA cis rs2204008 0.639 rs7311462 chr12:38278130 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.15 0.37 1.53e-22 Bladder cancer; BRCA cis rs12142240 0.698 rs13374893 chr1:46843800 A/G cg14993813 chr1:46806288 NSUN4 -0.5 -9.69 -0.36 8.4e-21 Menopause (age at onset); BRCA cis rs9457247 0.529 rs6907666 chr6:167523395 A/G cg07741184 chr6:167504864 NA -0.31 -9.13 -0.34 8.91e-19 Crohn's disease; BRCA cis rs1707322 1.000 rs12124847 chr1:46380850 T/A cg03146154 chr1:46216737 IPP 0.51 11.11 0.4 2.32e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs8062405 1.000 rs62036621 chr16:28833299 C/A cg09719594 chr16:21412588 NA -0.32 -7.82 -0.3 2.19e-14 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs887829 0.570 rs6753320 chr2:234595615 G/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 0.32 8.15 0.31 1.9e-15 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs877529 0.967 rs12158877 chr22:39549426 T/G cg12193277 chr22:39547181 CBX7 0.47 12.67 0.45 5.71e-33 Multiple myeloma; BRCA cis rs17270561 1.000 rs79867288 chr6:25828416 A/G cg16482183 chr6:26056742 HIST1H1C 0.74 12.96 0.46 2.9e-34 Iron status biomarkers; BRCA cis rs2050392 0.789 rs303438 chr10:30733493 C/T cg18806716 chr10:30721971 MAP3K8 0.38 9.1 0.34 1.18e-18 Inflammatory bowel disease; BRCA cis rs798554 0.757 rs1182188 chr7:2869985 T/C cg14863265 chr7:2801509 GNA12 -0.42 -9.19 -0.34 5.48e-19 Height; BRCA cis rs10463316 0.894 rs6579875 chr5:150782574 C/T cg03212797 chr5:150827313 SLC36A1 -0.39 -7.85 -0.3 1.79e-14 Metabolite levels (Pyroglutamine); BRCA cis rs2842992 0.709 rs1853257 chr6:160212710 C/G cg16489826 chr6:160211363 TCP1;MRPL18 0.6 12.57 0.45 1.6e-32 Age-related macular degeneration (geographic atrophy); BRCA cis rs11690935 0.959 rs6705200 chr2:172637600 A/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -31.68 -0.78 3.91e-133 Schizophrenia; BRCA cis rs2836974 0.644 rs719230 chr21:40676307 C/T cg11644478 chr21:40555479 PSMG1 -0.66 -14.66 -0.5 3.85e-42 Cognitive function; BRCA cis rs6879260 1.000 rs1035411 chr5:179729519 A/G cg02891314 chr5:179741120 GFPT2 -0.67 -13.25 -0.46 1.44e-35 Height; BRCA cis rs4409675 0.576 rs12070659 chr1:28227175 G/A cg23691781 chr1:28212827 C1orf38 0.32 10.71 0.39 9.82e-25 Corneal astigmatism; BRCA cis rs2742234 0.910 rs2505505 chr10:43648221 G/T cg02780029 chr10:43622663 RET -0.4 -10.08 -0.37 2.94e-22 Hirschsprung disease; BRCA cis rs9733 0.596 rs2867300 chr1:150666990 C/G cg04414720 chr1:150670196 GOLPH3L 0.36 8.17 0.31 1.6e-15 Tonsillectomy; BRCA trans rs853679 0.607 rs34950484 chr6:28278688 G/A cg06606381 chr12:133084897 FBRSL1 -0.85 -8.85 -0.33 8.54e-18 Depression; BRCA cis rs1448094 0.512 rs6539931 chr12:86247473 C/T cg19622623 chr12:86230825 RASSF9 -0.33 -9.32 -0.35 1.83e-19 Major depressive disorder; BRCA cis rs9811920 0.599 rs1688758 chr3:99539890 A/T cg07805332 chr3:99536008 MIR548G;C3orf26 0.37 8.35 0.31 4.09e-16 Axial length; BRCA cis rs9487051 0.872 rs9400269 chr6:109606065 C/G cg21918786 chr6:109611834 NA -0.48 -13.98 -0.48 6.15e-39 Reticulocyte fraction of red cells; BRCA cis rs10504229 0.775 rs55825382 chr8:58157605 G/A cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs11098499 0.909 rs17046118 chr4:120387496 T/G cg09307838 chr4:120376055 NA 0.75 16.17 0.54 1.48e-49 Corneal astigmatism; BRCA cis rs11098499 0.754 rs714899 chr4:120243035 G/A cg09307838 chr4:120376055 NA 0.64 13.64 0.47 2.27e-37 Corneal astigmatism; BRCA cis rs1862618 0.525 rs2662016 chr5:56269047 A/G cg12311346 chr5:56204834 C5orf35 0.9 16.93 0.56 2.27e-53 Initial pursuit acceleration; BRCA cis rs523522 1.000 rs523522 chr12:121020250 A/T cg12219531 chr12:120966889 COQ5 0.53 11.21 0.41 9.63e-27 High light scatter reticulocyte count; BRCA trans rs11764590 0.671 rs12669370 chr7:2081914 G/A cg11693508 chr17:37793320 STARD3 0.41 8.55 0.32 8.77e-17 Neuroticism; BRCA trans rs60843830 1.000 rs62114505 chr2:242426 A/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.68 14.82 0.51 6.58e-43 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs66887589 0.616 rs11098497 chr4:120187068 C/T cg09307838 chr4:120376055 NA 0.46 9.5 0.35 3.99e-20 Diastolic blood pressure; BRCA cis rs9811920 0.666 rs793456 chr3:99525631 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.52 -12.3 -0.44 2.38e-31 Axial length; BRCA cis rs796364 1.000 rs1509835 chr2:200814809 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 0.69 11.77 0.42 4.24e-29 Schizophrenia; BRCA cis rs7811142 0.830 rs11768967 chr7:99967644 G/A cg00814883 chr7:100076585 TSC22D4 -0.47 -10.6 -0.39 2.63e-24 Platelet count; BRCA cis rs4363385 0.667 rs399550 chr1:153049917 T/C cg25856811 chr1:152973957 SPRR3 -0.31 -8.01 -0.3 5.53e-15 Inflammatory skin disease; BRCA cis rs2816062 0.775 rs2816046 chr1:18893708 A/G cg18795169 chr1:18902165 NA -0.9 -26.49 -0.72 6.1e-105 Urate levels in lean individuals; BRCA cis rs34779708 0.966 rs11010135 chr10:35518063 A/G cg03585969 chr10:35415529 CREM 0.53 10.37 0.38 2.17e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs9487051 0.872 rs9487033 chr6:109605388 C/G cg01475377 chr6:109611718 NA 0.6 16.65 0.55 5.51e-52 Reticulocyte fraction of red cells; BRCA cis rs7589728 0.563 rs12479338 chr2:88444513 C/T cg24977027 chr2:88469347 THNSL2 0.56 9.54 0.35 2.92e-20 Plasma clusterin levels; BRCA cis rs4925325 0.956 rs1776263 chr20:60515820 A/G cg12751644 chr20:60527061 NA -0.39 -8.32 -0.31 5.28e-16 Obesity-related traits; BRCA cis rs1707322 0.686 rs1250 chr1:46094027 A/G cg03146154 chr1:46216737 IPP 0.49 10.79 0.39 4.77e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg13114125 chr14:105738426 BRF1 -0.53 -11.07 -0.4 3.42e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg04317338 chr11:64019027 PLCB3 0.53 9.42 0.35 8.34e-20 Mean platelet volume; BRCA cis rs55665837 1.000 rs12295888 chr11:14450531 T/C cg19336497 chr11:14380999 RRAS2 -0.36 -9.47 -0.35 5.33e-20 Vitamin D levels; BRCA cis rs10782582 0.593 rs6675212 chr1:76230829 C/A cg03433033 chr1:76189801 ACADM -0.49 -10.21 -0.37 9.23e-23 Daytime sleep phenotypes; BRCA cis rs9291683 0.538 rs11727199 chr4:10036190 C/T cg00071950 chr4:10020882 SLC2A9 0.64 15.9 0.53 3.13e-48 Bone mineral density; BRCA cis rs2404602 0.735 rs2461870 chr15:76813920 T/G cg23625390 chr15:77176239 SCAPER -0.49 -12.69 -0.45 4.43e-33 Blood metabolite levels; BRCA cis rs769267 0.965 rs1010207 chr19:19416045 T/C cg02546618 chr19:19431379 KIAA0892;SF4 0.4 9.44 0.35 6.94e-20 Tonsillectomy; BRCA cis rs9443645 0.901 rs9343843 chr6:79585625 C/T cg09184832 chr6:79620586 NA -0.51 -11.12 -0.4 2.32e-26 Intelligence (multi-trait analysis); BRCA cis rs13631 0.928 rs9411308 chr9:140000115 C/T cg14289826 chr9:140003911 NA 0.53 13.96 0.48 7.92e-39 Cerebrospinal fluid biomarker levels; BRCA cis rs3858526 0.839 rs10466484 chr11:5943696 A/G cg13902645 chr11:5959945 NA -0.52 -10.56 -0.39 3.93e-24 DNA methylation (variation); BRCA cis rs1420338 0.967 rs10271544 chr7:34147159 C/T cg01275685 chr7:34179230 BMPER -0.52 -11.58 -0.42 2.87e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs12887734 0.524 rs722637 chr14:104261723 G/T cg26031613 chr14:104095156 KLC1 0.5 9.09 0.34 1.28e-18 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs9287719 0.967 rs12622765 chr2:10728331 T/C cg02196655 chr2:10830764 NOL10 -0.3 -8.09 -0.3 3.04e-15 Prostate cancer; BRCA cis rs1371614 0.577 rs877274 chr2:27140099 A/C cg12368169 chr2:27073192 DPYSL5 -0.29 -8.73 -0.33 2.13e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs2463822 0.764 rs7125402 chr11:62097259 C/T cg06239285 chr11:62104954 ASRGL1 0.66 11.05 0.4 4.1e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1552244 0.882 rs3755783 chr3:10029289 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.97 -0.37 7.49e-22 Alzheimer's disease; BRCA cis rs7312933 0.703 rs12370778 chr12:42599696 T/A cg17420585 chr12:42539391 GXYLT1 -0.38 -8.06 -0.3 3.77e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs826838 0.967 rs11169387 chr12:39145737 C/T cg13010199 chr12:38710504 ALG10B 0.53 11.62 0.42 1.8e-28 Heart rate; BRCA cis rs17376456 0.877 rs17374627 chr5:93296306 C/T cg25358565 chr5:93447407 FAM172A 1.14 18.05 0.58 3.61e-59 Diabetic retinopathy; BRCA cis rs1008375 0.931 rs979823 chr4:17700176 G/A cg02297831 chr4:17616191 MED28 0.37 8.49 0.32 1.44e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9858542 0.953 rs1987628 chr3:49399259 G/A cg03060546 chr3:49711283 APEH -0.48 -9.56 -0.35 2.39e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs931812 0.895 rs7831714 chr8:101913987 C/T cg20993868 chr7:22813445 NA 0.52 14.16 0.49 8.26e-40 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs4363385 0.818 rs4576617 chr1:152985729 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.41 -0.32 2.64e-16 Inflammatory skin disease; BRCA cis rs2836974 0.931 rs2776307 chr21:40713833 C/G cg11644478 chr21:40555479 PSMG1 -0.75 -16.32 -0.54 2.56e-50 Cognitive function; BRCA cis rs1475911 1.000 rs2839466 chr21:43512324 A/G cg24372256 chr21:43528868 UMODL1;C21orf128 0.39 8.4 0.32 2.86e-16 IgG glycosylation; BRCA cis rs1865760 0.573 rs7450342 chr6:25919480 T/C cg03264133 chr6:25882463 NA -0.41 -9.19 -0.34 5.63e-19 Height; BRCA cis rs514406 0.929 rs12354395 chr1:53327663 A/G cg08859206 chr1:53392774 SCP2 -0.51 -11.21 -0.41 9.64e-27 Monocyte count; BRCA cis rs1707322 1.000 rs10890360 chr1:46338444 C/T cg03146154 chr1:46216737 IPP 0.45 10.08 0.37 2.88e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7582180 0.627 rs2099611 chr2:101021090 A/G cg14675211 chr2:100938903 LONRF2 0.43 9.56 0.35 2.46e-20 Intelligence (multi-trait analysis); BRCA cis rs9329289 1.000 rs9329289 chr10:2542389 A/G cg15501526 chr10:2543763 NA 0.58 14.31 0.49 1.7e-40 Age-related hearing impairment; BRCA cis rs9287719 0.967 rs6721514 chr2:10751062 T/C cg02196655 chr2:10830764 NOL10 -0.3 -7.93 -0.3 9.52e-15 Prostate cancer; BRCA cis rs9837602 0.872 rs1489816 chr3:99769088 C/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.58 -10.94 -0.4 1.14e-25 Breast cancer; BRCA cis rs2549003 0.870 rs10053046 chr5:131821558 A/G cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.67e-34 Asthma (sex interaction); BRCA cis rs881375 0.631 rs2416808 chr9:123706283 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.53 11.54 0.42 4.18e-28 Rheumatoid arthritis; BRCA cis rs11105298 0.891 rs11105302 chr12:89891366 A/G cg08166232 chr12:89918718 WDR51B;GALNT4 0.56 9.5 0.35 4.16e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs11098499 0.820 rs13128602 chr4:120459366 C/T cg09307838 chr4:120376055 NA -0.7 -14.2 -0.49 5.79e-40 Corneal astigmatism; BRCA cis rs6952808 1.000 rs59248873 chr7:1888185 A/G cg13880726 chr7:1868755 MAD1L1 0.51 10.2 0.37 9.77e-23 Bipolar disorder and schizophrenia; BRCA cis rs6456156 0.586 rs1358882 chr6:167467101 G/A cg07741184 chr6:167504864 NA 0.33 9.76 0.36 4.48e-21 Primary biliary cholangitis; BRCA cis rs7772486 0.558 rs2142978 chr6:146012061 T/C cg23711669 chr6:146136114 FBXO30 -0.72 -14.58 -0.5 8.51e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs7659604 0.539 rs2221628 chr4:122795361 G/A cg19748678 chr4:122722346 EXOSC9 0.75 16.19 0.54 1.21e-49 Type 2 diabetes; BRCA cis rs60871478 0.786 rs55899111 chr7:827843 C/G cg27478167 chr7:817139 HEATR2 0.58 11.62 0.42 1.87e-28 Cerebrospinal P-tau181p levels; BRCA cis rs12142240 0.698 rs61519400 chr1:46855298 A/G cg14993813 chr1:46806288 NSUN4 -0.49 -9.62 -0.36 1.48e-20 Menopause (age at onset); BRCA cis rs933688 0.938 rs7705465 chr5:90680949 G/A cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 18.9 0.6 1.21e-63 Smoking behavior; BRCA cis rs10256972 0.504 rs2949178 chr7:1209925 T/C cg09177884 chr7:1199841 ZFAND2A -0.64 -16.56 -0.55 1.55e-51 Longevity;Endometriosis; BRCA trans rs4650994 0.525 rs4457535 chr1:178497186 C/T cg05059571 chr16:84539110 KIAA1609 0.49 11.27 0.41 5.6e-27 HDL cholesterol levels;HDL cholesterol; BRCA cis rs11971779 0.680 rs11772026 chr7:139052589 T/G cg07862535 chr7:139043722 LUC7L2 0.38 10.24 0.38 6.65e-23 Diisocyanate-induced asthma; BRCA cis rs2882667 0.690 rs288018 chr5:138192416 G/A cg04439458 chr5:138467593 SIL1 0.35 8.57 0.32 7.79e-17 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7666738 0.753 rs9991512 chr4:99007205 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.51 0.57 2.31e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.600 rs1128419 chr11:1010750 G/A ch.11.42038R chr11:967971 AP2A2 0.46 13.86 0.48 2.2e-38 Alzheimer's disease (late onset); BRCA cis rs10927875 0.965 rs3961710 chr1:16313172 C/T cg21385522 chr1:16154831 NA -0.62 -11.39 -0.41 1.69e-27 Dilated cardiomyopathy; BRCA cis rs9831754 1.000 rs9855903 chr3:78347988 C/A cg06138941 chr3:78371609 NA -0.81 -17.48 -0.57 3.45e-56 Calcium levels; BRCA cis rs6951245 0.554 rs4724294 chr7:1139695 G/A cg04025307 chr7:1156635 C7orf50 0.52 9.99 0.37 6.34e-22 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6582630 0.538 rs7971292 chr12:38498151 A/G cg26384229 chr12:38710491 ALG10B -0.44 -10.23 -0.38 7.53e-23 Drug-induced liver injury (flucloxacillin); BRCA cis rs2243480 1.000 rs67536397 chr7:65947917 G/A cg18252515 chr7:66147081 NA -1.07 -15.92 -0.53 2.69e-48 Diabetic kidney disease; BRCA cis rs7582180 0.606 rs11684004 chr2:100954783 C/T cg14675211 chr2:100938903 LONRF2 0.52 11.67 0.42 1.16e-28 Intelligence (multi-trait analysis); BRCA cis rs600231 0.708 rs1784100 chr11:65249227 T/C cg01292856 chr11:65242576 NA 0.36 9.04 0.34 1.85e-18 Bone mineral density; BRCA cis rs9926296 0.656 rs11861084 chr16:89875710 G/T cg04287289 chr16:89883240 FANCA -0.65 -14.49 -0.5 2.51e-41 Vitiligo; BRCA cis rs1129187 0.755 rs9471988 chr6:42944773 T/C cg05552183 chr6:42928497 GNMT 0.69 15.48 0.52 3.7e-46 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs7944735 0.517 rs74763661 chr11:48233772 T/C cg15704280 chr7:45808275 SEPT13 0.54 8.2 0.31 1.31e-15 Intraocular pressure; BRCA cis rs2204008 0.837 rs11495722 chr12:38337245 G/A cg13010199 chr12:38710504 ALG10B 0.51 10.18 0.37 1.22e-22 Bladder cancer; BRCA cis rs7927592 0.871 rs871212 chr11:68348695 T/A cg20283391 chr11:68216788 NA -0.44 -8.95 -0.33 3.75e-18 Total body bone mineral density; BRCA cis rs27434 0.607 rs26654 chr5:96140367 C/T cg16492584 chr5:96139282 ERAP1 -0.51 -13.2 -0.46 2.3e-35 Ankylosing spondylitis; BRCA cis rs10911232 0.507 rs4652767 chr1:183002483 G/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.7 0.55 3.14e-52 Hypertriglyceridemia; BRCA cis rs4319547 0.695 rs11836188 chr12:122865507 T/C cg23029597 chr12:123009494 RSRC2 0.58 11.48 0.41 7.41e-28 Body mass index; BRCA cis rs12142240 0.698 rs68112720 chr1:46813888 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs2153535 0.601 rs9379224 chr6:8538413 A/G cg21535247 chr6:8435926 SLC35B3 0.39 8.63 0.32 4.82e-17 Motion sickness; BRCA cis rs10504229 0.871 rs56372514 chr8:58157166 A/G cg22535103 chr8:58192502 C8orf71 -0.51 -10.92 -0.4 1.37e-25 Developmental language disorder (linguistic errors); BRCA cis rs9393692 0.905 rs7450556 chr6:26299900 C/T cg00631329 chr6:26305371 NA -0.44 -12.92 -0.46 4.11e-34 Educational attainment; BRCA cis rs11677370 0.574 rs10190477 chr2:3862738 A/G cg17052675 chr2:3827356 NA 0.52 12.48 0.44 3.65e-32 Type 2 diabetes; BRCA cis rs4481887 0.927 rs4472779 chr1:248474603 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.39 0.31 3.15e-16 Common traits (Other); BRCA cis rs9467773 1.000 rs2224380 chr6:26553943 G/A cg09904177 chr6:26538194 HMGN4 0.55 17.67 0.57 3.26e-57 Intelligence (multi-trait analysis); BRCA cis rs11098499 0.691 rs12510133 chr4:120271344 A/C cg09307838 chr4:120376055 NA 0.6 12.94 0.46 3.6e-34 Corneal astigmatism; BRCA cis rs11252926 0.797 rs61837235 chr10:489363 G/A cg08603382 chr10:743973 NA -0.45 -8.34 -0.31 4.54e-16 Psychosis in Alzheimer's disease; BRCA cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg22153463 chr1:85462885 MCOLN2 -0.6 -10.72 -0.39 9.34e-25 Serum sulfate level; BRCA cis rs250677 0.687 rs40149 chr5:148444275 A/T cg23229984 chr5:148520753 ABLIM3 0.36 8.87 0.33 7.15e-18 Breast cancer; BRCA cis rs561341 1.000 rs501312 chr17:30329066 A/G cg00745463 chr17:30367425 LRRC37B -0.54 -8.87 -0.33 7.06e-18 Hip circumference adjusted for BMI; BRCA trans rs9393777 0.920 rs13191227 chr6:27390115 G/C cg01620082 chr3:125678407 NA -0.86 -10.28 -0.38 4.77e-23 Intelligence (multi-trait analysis); BRCA cis rs4077515 0.934 rs10781507 chr9:139272058 A/G cg14019695 chr9:139328340 INPP5E 0.32 7.96 0.3 7.73e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs1005277 0.579 rs2474580 chr10:38398713 G/A cg00409905 chr10:38381863 ZNF37A -0.52 -11.13 -0.4 1.98e-26 Extrinsic epigenetic age acceleration; BRCA cis rs60871478 1.000 rs62432253 chr7:802928 A/G cg27478167 chr7:817139 HEATR2 -0.54 -11.0 -0.4 6.94e-26 Cerebrospinal P-tau181p levels; BRCA cis rs7072216 0.655 rs3830025 chr10:100176104 A/G cg26618903 chr10:100175079 PYROXD2 -0.32 -8.93 -0.33 4.6e-18 Metabolite levels; BRCA trans rs61931739 0.534 rs11053131 chr12:34282109 A/G cg13010199 chr12:38710504 ALG10B 0.36 7.87 0.3 1.52e-14 Morning vs. evening chronotype; BRCA cis rs2836974 0.590 rs11911822 chr21:40607843 C/T cg17971929 chr21:40555470 PSMG1 -0.64 -14.9 -0.51 2.57e-43 Cognitive function; BRCA cis rs7903847 0.619 rs76094900 chr10:99158164 G/A cg08345082 chr10:99160200 RRP12 -0.31 -9.08 -0.34 1.29e-18 Granulocyte percentage of myeloid white cells; BRCA trans rs1997103 0.954 rs56030000 chr7:55405750 A/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.34e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs12477438 0.520 rs4851188 chr2:99745898 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.76 20.88 0.64 3.29e-74 Chronic sinus infection; BRCA cis rs4481887 0.927 rs12044126 chr1:248481952 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.95 0.33 3.99e-18 Common traits (Other); BRCA cis rs7659604 0.582 rs3217780 chr4:122737278 T/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.5 -0.44 3.1e-32 Type 2 diabetes; BRCA cis rs4975709 0.589 rs4975745 chr5:1861058 G/C cg11168104 chr5:1857477 NA -0.35 -9.33 -0.35 1.67e-19 Cardiovascular disease risk factors; BRCA cis rs10504229 1.000 rs66840104 chr8:58190001 C/T cg05313129 chr8:58192883 C8orf71 -0.48 -9.87 -0.36 1.8e-21 Developmental language disorder (linguistic errors); BRCA cis rs1008375 1.000 rs10440301 chr4:17663199 G/A cg16339924 chr4:17578868 LAP3 0.59 14.44 0.5 4.24e-41 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7729447 0.813 rs4867121 chr5:32692548 T/C cg16267343 chr5:32710456 NPR3 0.42 8.54 0.32 9.71e-17 Blood pressure; BRCA cis rs2204008 0.627 rs10878488 chr12:38148666 G/A cg26384229 chr12:38710491 ALG10B 0.76 16.99 0.56 1.09e-53 Bladder cancer; BRCA cis rs2180341 0.960 rs6900074 chr6:127685893 A/G cg27446573 chr6:127587934 RNF146 0.86 19.7 0.61 7.62e-68 Breast cancer; BRCA cis rs1400816 0.850 rs6433315 chr2:172686290 A/G cg13550731 chr2:172543902 DYNC1I2 -0.55 -8.46 -0.32 1.77e-16 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs9467773 0.620 rs2504566 chr6:26660488 G/C cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.02e-42 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg26119090 chr2:26468346 HADHA;HADHB 1.05 22.15 0.66 4.01e-81 Gut microbiome composition (summer); BRCA cis rs208520 0.690 rs12201156 chr6:66720874 G/T cg07460842 chr6:66804631 NA 0.93 18.55 0.59 8.93e-62 Exhaled nitric oxide output; BRCA cis rs4819052 0.851 rs2838857 chr21:46681000 A/G cg11663144 chr21:46675770 NA -0.56 -13.38 -0.47 3.43e-36 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2243480 1.000 rs778679 chr7:65840911 A/G cg18252515 chr7:66147081 NA -1.08 -16.09 -0.54 3.78e-49 Diabetic kidney disease; BRCA cis rs490234 0.841 rs490333 chr9:128354569 T/C cg14078157 chr9:128172775 NA 0.34 7.88 0.3 1.41e-14 Mean arterial pressure; BRCA cis rs9815354 0.556 rs113213296 chr3:41873097 G/A cg03022575 chr3:42003672 ULK4 0.69 9.47 0.35 5.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg22638593 chr5:131593259 PDLIM4 -0.34 -8.59 -0.32 6.59e-17 Acylcarnitine levels; BRCA cis rs17767294 0.614 rs72845061 chr6:27653261 G/A cg08851530 chr6:28072375 NA 0.95 8.95 0.33 3.95e-18 Parkinson's disease; BRCA cis rs796364 1.000 rs281783 chr2:200751582 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 0.77 12.95 0.46 3.07e-34 Schizophrenia; BRCA cis rs1862618 0.613 rs252889 chr5:56227069 C/A cg22800045 chr5:56110881 MAP3K1 0.46 9.1 0.34 1.14e-18 Initial pursuit acceleration; BRCA cis rs10256972 0.681 rs12702016 chr7:1129392 C/T cg09177884 chr7:1199841 ZFAND2A -0.5 -10.61 -0.39 2.37e-24 Longevity;Endometriosis; BRCA cis rs941873 0.772 rs7086293 chr10:81103247 T/C cg08514558 chr10:81106712 PPIF 0.37 8.77 0.33 1.58e-17 Height; BRCA cis rs1552244 1.000 rs17032278 chr3:10077955 A/G cg00149659 chr3:10157352 C3orf10 0.79 13.72 0.48 9.42e-38 Alzheimer's disease; BRCA cis rs6952808 0.723 rs1107592 chr7:2041432 C/T cg18279126 chr7:2041391 MAD1L1 -0.39 -9.05 -0.34 1.72e-18 Bipolar disorder and schizophrenia; BRCA cis rs7903847 0.642 rs10786344 chr10:99165975 T/C cg08345082 chr10:99160200 RRP12 -0.3 -8.78 -0.33 1.44e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs72781680 1.000 rs56339200 chr2:24188194 C/A cg20701182 chr2:24300061 SF3B14 0.58 9.2 0.34 5.02e-19 Lymphocyte counts; BRCA cis rs2075371 0.933 rs1868784 chr7:133945932 A/G cg11752832 chr7:134001865 SLC35B4 0.49 12.1 0.43 1.76e-30 Mean platelet volume; BRCA cis rs4363385 0.510 rs6686526 chr1:153044996 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -7.83 -0.3 2.11e-14 Inflammatory skin disease; BRCA cis rs12701220 0.655 rs34344742 chr7:1149288 C/G cg16145915 chr7:1198662 ZFAND2A -0.47 -9.36 -0.35 1.34e-19 Bronchopulmonary dysplasia; BRCA cis rs36051895 0.664 rs10815157 chr9:5108771 C/G cg02405213 chr9:5042618 JAK2 -0.48 -9.1 -0.34 1.12e-18 Pediatric autoimmune diseases; BRCA cis rs2235642 0.826 rs8053605 chr16:1594158 G/A cg09065629 chr16:1709722 CRAMP1L 0.36 8.32 0.31 5.17e-16 Coronary artery disease; BRCA cis rs9287719 0.901 rs4555317 chr2:10744247 A/G cg00105475 chr2:10696890 NA 0.44 10.44 0.38 1.2e-23 Prostate cancer; BRCA cis rs919433 0.963 rs12469546 chr2:198178826 T/C cg10820045 chr2:198174542 NA -0.38 -7.9 -0.3 1.25e-14 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs12986413 0.781 rs2864419 chr19:2183175 A/C cg09261902 chr19:2140048 AP3D1 -0.39 -9.99 -0.37 6.26e-22 Height; BRCA cis rs1215050 0.765 rs6852699 chr4:98767505 T/C cg05340658 chr4:99064831 C4orf37 0.45 10.24 0.38 7.17e-23 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2712184 0.756 rs715049 chr2:217657102 C/T cg05032264 chr2:217675019 NA -0.38 -9.14 -0.34 7.89e-19 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs270601 0.633 rs733300 chr5:131572243 A/G cg12564285 chr5:131593104 PDLIM4 0.39 9.64 0.36 1.24e-20 Acylcarnitine levels; BRCA trans rs9784649 1.000 rs56156666 chr5:24999440 A/T cg08600765 chr20:34638493 LOC647979 -0.52 -8.65 -0.32 4e-17 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs35306767 0.904 rs10904584 chr10:983747 A/T cg20503657 chr10:835505 NA 0.85 15.1 0.51 2.69e-44 Eosinophil percentage of granulocytes; BRCA cis rs1153858 1.000 rs12101539 chr15:45650666 C/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.73 0.42 6.29e-29 Homoarginine levels; BRCA cis rs611744 0.625 rs6469168 chr8:109288399 G/T cg18478394 chr8:109455254 TTC35 0.3 8.61 0.32 5.65e-17 Dupuytren's disease; BRCA cis rs13256369 1.000 rs13256369 chr8:8577379 T/C cg18904891 chr8:8559673 CLDN23 0.56 11.01 0.4 6.42e-26 Obesity-related traits; BRCA cis rs2050392 0.517 rs593400 chr10:30762088 A/G cg25182066 chr10:30743637 MAP3K8 0.34 8.21 0.31 1.21e-15 Inflammatory bowel disease; BRCA cis rs3820928 1.000 rs2396433 chr2:227772502 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.41 -0.32 2.72e-16 Pulmonary function; BRCA cis rs877282 1.000 rs12773872 chr10:771939 T/C cg17470449 chr10:769945 NA 0.5 8.9 0.33 5.64e-18 Uric acid levels; BRCA cis rs4363385 0.747 rs4845508 chr1:152968421 G/C cg24667326 chr1:152973720 SPRR3 -0.36 -9.89 -0.36 1.54e-21 Inflammatory skin disease; BRCA cis rs77861329 1.000 rs164639 chr3:52210872 A/G cg08692210 chr3:52188851 WDR51A -0.67 -11.37 -0.41 1.99e-27 Macrophage inflammatory protein 1b levels; BRCA cis rs4727027 0.933 rs4727028 chr7:148874666 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 -0.4 -8.84 -0.33 9.57e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs858239 0.539 rs6965833 chr7:23192366 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.89 0.4 1.84e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs10754283 0.840 rs6428560 chr1:90102462 A/T cg21401794 chr1:90099060 LRRC8C 0.47 11.3 0.41 3.96e-27 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs67460515 0.563 rs13085336 chr3:160880599 G/A cg03342759 chr3:160939853 NMD3 -0.7 -14.6 -0.5 7.51e-42 Parkinson's disease; BRCA cis rs6460942 0.915 rs62448623 chr7:12464122 A/G cg10578991 chr7:12443926 VWDE -0.57 -8.06 -0.3 3.71e-15 Coronary artery disease; BRCA cis rs9388451 0.559 rs1777210 chr6:126098916 T/G cg05901451 chr6:126070800 HEY2 -0.54 -14.24 -0.49 3.76e-40 Brugada syndrome; BRCA cis rs1008375 0.966 rs6833808 chr4:17652526 T/A cg04450456 chr4:17643702 FAM184B 0.39 11.59 0.42 2.58e-28 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs34779708 0.931 rs10466072 chr10:35402756 C/T cg03585969 chr10:35415529 CREM 0.44 9.34 0.35 1.54e-19 Inflammatory bowel disease;Crohn's disease; BRCA cis rs903263 0.512 rs1325602 chr1:84505777 C/T cg10977910 chr1:84465055 TTLL7 0.46 9.05 0.34 1.74e-18 Breast cancer (male); BRCA cis rs4466137 0.794 rs6869296 chr5:83007333 C/G cg16102102 chr5:83017553 HAPLN1 0.77 16.39 0.54 1.18e-50 Prostate cancer; BRCA cis rs9649213 0.574 rs6961790 chr7:98007993 C/G cg01877450 chr7:97915802 BRI3 -0.38 -8.76 -0.33 1.81e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs7119038 0.509 rs10790261 chr11:118579747 C/T cg19308663 chr11:118741387 NA -0.39 -8.46 -0.32 1.77e-16 Sjögren's syndrome; BRCA cis rs2204008 0.684 rs11514164 chr12:38036494 C/T cg26384229 chr12:38710491 ALG10B 0.66 15.19 0.52 1.03e-44 Bladder cancer; BRCA cis rs7631605 0.935 rs7639375 chr3:37107022 C/A cg15934958 chr3:37212084 LRRFIP2 0.41 9.51 0.35 3.69e-20 Cerebrospinal P-tau181p levels; BRCA cis rs10751667 1.000 rs7395632 chr11:958789 C/T cg01483505 chr11:975446 AP2A2 -0.33 -8.97 -0.33 3.14e-18 Alzheimer's disease (late onset); BRCA trans rs208520 0.690 rs6932475 chr6:66863155 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.06 -0.64 3.72e-75 Exhaled nitric oxide output; BRCA cis rs3796352 1.000 rs35737577 chr3:53002557 G/C cg07884673 chr3:53033167 SFMBT1 0.72 8.94 0.33 4.2e-18 Immune reponse to smallpox (secreted IL-2); BRCA cis rs12142240 0.698 rs72677599 chr1:46834251 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.27 0.31 7.52e-16 Menopause (age at onset); BRCA trans rs9329221 0.686 rs60755617 chr8:10243327 T/G cg15556689 chr8:8085844 FLJ10661 0.38 8.88 0.33 6.53e-18 Neuroticism; BRCA cis rs12142240 0.698 rs12385696 chr1:46818836 A/G cg00530320 chr1:46809349 NSUN4 0.48 9.42 0.35 8.17e-20 Menopause (age at onset); BRCA cis rs9287719 0.934 rs6706763 chr2:10751407 C/T cg00105475 chr2:10696890 NA 0.44 10.36 0.38 2.45e-23 Prostate cancer; BRCA cis rs6570726 1.000 rs441477 chr6:145848243 C/T cg23711669 chr6:146136114 FBXO30 0.65 15.3 0.52 2.96e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs801193 0.967 rs2707849 chr7:66152712 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.4 0.32 2.9e-16 Aortic root size; BRCA cis rs6598955 0.671 rs17163868 chr1:26648381 A/G cg04990556 chr1:26633338 UBXN11 -0.51 -8.85 -0.33 8.49e-18 Obesity-related traits; BRCA cis rs514406 0.800 rs7548519 chr1:53294473 A/G cg25767906 chr1:53392781 SCP2 -0.37 -8.62 -0.32 5.27e-17 Monocyte count; BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg03934478 chr11:495069 RNH1 0.79 11.76 0.42 5.06e-29 Body mass index; BRCA cis rs2404602 1.000 rs2404740 chr15:76852143 C/T cg23625390 chr15:77176239 SCAPER 0.44 10.97 0.4 9.14e-26 Blood metabolite levels; BRCA cis rs12142240 0.698 rs72677600 chr1:46834449 G/A cg14993813 chr1:46806288 NSUN4 -0.49 -9.33 -0.35 1.75e-19 Menopause (age at onset); BRCA cis rs10504073 0.669 rs818559 chr8:50035806 C/T cg00325661 chr8:49890786 NA 0.38 10.92 0.4 1.42e-25 Blood metabolite ratios; BRCA cis rs780096 0.526 rs780102 chr2:27659491 T/C cg22903471 chr2:27725779 GCKR -0.38 -9.4 -0.35 9.77e-20 Total body bone mineral density; BRCA cis rs780096 0.526 rs704791 chr2:27657167 T/C cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs473651 0.692 rs579511 chr2:239334914 C/G cg21699342 chr2:239360505 ASB1 0.53 13.95 0.48 8.34e-39 Multiple system atrophy; BRCA cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13012494 chr21:47604986 C21orf56 0.42 8.89 0.33 6.4e-18 Testicular germ cell tumor; BRCA cis rs17270561 0.609 rs9358873 chr6:25731783 C/T cg16482183 chr6:26056742 HIST1H1C 0.5 9.39 0.35 1.03e-19 Iron status biomarkers; BRCA cis rs6570726 0.755 rs2092296 chr6:145893684 A/C cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.95e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs9517320 0.534 rs912330 chr13:99131294 C/T cg07423050 chr13:99094983 FARP1 -0.45 -9.37 -0.35 1.26e-19 Longevity; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg03188948 chr7:1209495 NA 0.53 9.95 0.37 8.57e-22 Longevity;Endometriosis; BRCA cis rs4689388 0.824 rs4467645 chr4:6294305 C/T cg25554036 chr4:6271136 WFS1 0.43 10.04 0.37 3.93e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs2153535 0.580 rs4639392 chr6:8446547 A/G cg07606381 chr6:8435919 SLC35B3 0.65 14.3 0.49 1.92e-40 Motion sickness; BRCA cis rs9649213 0.593 rs6969731 chr7:97924571 T/G cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.37e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6772849 0.930 rs9868579 chr3:128351054 C/T cg16766828 chr3:128327626 NA 0.39 8.62 0.32 5.26e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs875971 0.540 rs35510581 chr7:65578777 G/A cg11764359 chr7:65958608 NA -0.61 -13.29 -0.47 9.53e-36 Aortic root size; BRCA trans rs9329221 0.967 rs7005363 chr8:10283748 C/T cg15556689 chr8:8085844 FLJ10661 -0.3 -7.98 -0.3 7e-15 Neuroticism; BRCA cis rs11809207 0.523 rs2783707 chr1:26504196 C/G cg00147160 chr1:26503991 CNKSR1 0.28 9.22 0.34 4.34e-19 Height; BRCA cis rs6748734 1.000 rs6724662 chr2:241831560 A/G cg02820040 chr2:241836501 C2orf54 -0.54 -10.23 -0.38 7.52e-23 Urinary metabolites; BRCA cis rs6121246 0.779 rs6060763 chr20:30282223 A/G cg13852791 chr20:30311386 BCL2L1 0.85 16.95 0.56 1.63e-53 Mean corpuscular hemoglobin; BRCA cis rs9443645 0.869 rs6926537 chr6:79554193 T/A cg11833968 chr6:79620685 NA -0.46 -10.41 -0.38 1.49e-23 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs732299 chr4:98995389 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.59 0.39 2.87e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs1005277 0.505 rs10827836 chr10:38215441 A/G cg00409905 chr10:38381863 ZNF37A 0.49 10.62 0.39 2.17e-24 Extrinsic epigenetic age acceleration; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.13e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4588572 0.688 rs2362829 chr5:77724036 T/A cg11547950 chr5:77652471 NA -0.45 -8.55 -0.32 9.08e-17 Triglycerides; BRCA trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -16.96 -0.56 1.52e-53 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.782 rs1454651 chr21:45012476 A/G cg01579765 chr21:45077557 HSF2BP -0.44 -11.68 -0.42 1.07e-28 Mean corpuscular volume; BRCA cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg26248373 chr2:1572462 NA -0.63 -14.52 -0.5 1.68e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs4819052 0.851 rs7275468 chr21:46656499 C/A cg11663144 chr21:46675770 NA -0.53 -12.45 -0.44 5.15e-32 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2011503 0.882 rs751857 chr19:19602873 G/T cg15839431 chr19:19639596 YJEFN3 -0.42 -9.18 -0.34 6e-19 Bipolar disorder; BRCA trans rs9944715 1.000 rs9951624 chr18:43840829 A/G cg01718231 chr17:29326311 RNF135 -0.46 -9.13 -0.34 8.8e-19 Red cell distribution width;Mean corpuscular volume; BRCA cis rs12477438 0.700 rs10190421 chr2:99670711 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.7 -0.5 2.35e-42 Chronic sinus infection; BRCA cis rs7727544 0.507 rs10051679 chr5:131570931 T/A cg09877947 chr5:131593287 PDLIM4 0.34 7.95 0.3 8.7e-15 Blood metabolite levels; BRCA cis rs77972916 0.611 rs11693190 chr2:43602415 A/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.61 -10.59 -0.39 2.85e-24 Granulocyte percentage of myeloid white cells; BRCA cis rs35123781 0.696 rs904612 chr5:139070952 G/A cg10513866 chr5:139070639 NA 0.44 9.62 0.36 1.44e-20 Schizophrenia; BRCA cis rs35306767 0.909 rs12264390 chr10:959111 T/C cg26597838 chr10:835615 NA 0.8 14.69 0.5 2.59e-42 Eosinophil percentage of granulocytes; BRCA cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg10523679 chr1:76189770 ACADM -0.71 -13.09 -0.46 7.79e-35 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4076764 0.958 rs11584957 chr1:163392937 C/T cg24596788 chr1:163392923 NA -0.4 -10.59 -0.39 2.85e-24 Motion sickness; BRCA cis rs7520050 0.933 rs6680211 chr1:46315007 C/G cg24296786 chr1:45957014 TESK2 0.41 9.35 0.35 1.5e-19 Red blood cell count;Reticulocyte count; BRCA cis rs17376456 0.825 rs10075217 chr5:93176774 C/G cg25358565 chr5:93447407 FAM172A 1.17 17.4 0.57 8.11e-56 Diabetic retinopathy; BRCA cis rs17711722 0.510 rs11767457 chr7:65290615 C/T cg05627663 chr7:65219948 SNORA22;CCT6P1 0.65 14.31 0.49 1.68e-40 Calcium levels; BRCA cis rs4595586 0.545 rs11609541 chr12:39378331 T/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.56e-19 Morning vs. evening chronotype; BRCA cis rs867371 0.929 rs1501371 chr15:82460440 A/C cg00614314 chr15:82944287 LOC80154 0.43 8.96 0.33 3.59e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs6952808 0.792 rs4421257 chr7:1955152 T/C cg05863683 chr7:1912471 MAD1L1 0.36 8.04 0.3 4.49e-15 Bipolar disorder and schizophrenia; BRCA trans rs7618501 1.000 rs6775384 chr3:49853073 G/A cg21659725 chr3:3221576 CRBN 0.71 21.65 0.65 2.21e-78 Intelligence (multi-trait analysis); BRCA trans rs9944715 1.000 rs8094070 chr18:43849640 G/A cg01718231 chr17:29326311 RNF135 -0.47 -9.2 -0.34 4.96e-19 Red cell distribution width;Mean corpuscular volume; BRCA cis rs7851660 0.901 rs2401639 chr9:100607837 T/C cg13688889 chr9:100608707 NA -0.35 -8.56 -0.32 8.52e-17 Strep throat; BRCA cis rs7666738 0.719 rs4699323 chr4:98967484 G/A cg17366294 chr4:99064904 C4orf37 0.52 9.72 0.36 6.3e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs4563143 0.647 rs117946634 chr19:29256822 G/T cg14983838 chr19:29218262 NA 0.54 10.09 0.37 2.65e-22 Methadone dose in opioid dependence; BRCA trans rs35110281 0.591 rs230642 chr21:44915533 A/C cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO -0.45 -9.55 -0.35 2.71e-20 Mean corpuscular volume; BRCA cis rs55728055 0.661 rs1018488 chr22:31992376 A/G cg01338084 chr22:32026380 PISD 0.85 8.37 0.31 3.62e-16 Age-related hearing impairment; BRCA cis rs6545883 0.929 rs2592352 chr2:61665336 C/T cg15711740 chr2:61764176 XPO1 -0.56 -14.22 -0.49 4.62e-40 Tuberculosis; BRCA cis rs701145 0.585 rs2689330 chr3:153929990 T/C cg17054900 chr3:154042577 DHX36 0.57 9.59 0.35 1.96e-20 Coronary artery disease; BRCA cis rs12477438 0.501 rs12613624 chr2:99732741 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.83 -25.62 -0.71 4.13e-100 Chronic sinus infection; BRCA cis rs10206020 0.879 rs72778007 chr2:1573178 C/T cg12573674 chr2:1569213 NA -0.62 -14.09 -0.49 1.83e-39 IgG glycosylation; BRCA cis rs4642101 0.618 rs7612317 chr3:12820558 C/T cg24848339 chr3:12840334 CAND2 0.49 13.29 0.47 9.14e-36 QRS complex (12-leadsum); BRCA trans rs11098499 0.820 rs13128602 chr4:120459366 C/T cg25214090 chr10:38739885 LOC399744 -0.54 -11.82 -0.42 2.73e-29 Corneal astigmatism; BRCA cis rs2540552 0.620 rs2540571 chr7:91206783 C/T cg15143024 chr7:91199642 NA -0.46 -11.34 -0.41 2.76e-27 IgG glycosylation; BRCA cis rs11690935 0.632 rs12052246 chr2:172895606 G/T cg13550731 chr2:172543902 DYNC1I2 0.57 14.48 0.5 2.75e-41 Schizophrenia; BRCA cis rs12618769 0.543 rs3769728 chr2:99103001 G/A cg10123293 chr2:99228465 UNC50 0.42 8.18 0.31 1.53e-15 Bipolar disorder; BRCA cis rs887829 0.570 rs7563561 chr2:234598991 A/C cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.31 -7.82 -0.3 2.18e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs72634258 0.554 rs17374781 chr1:7919363 A/G cg00042356 chr1:8021962 PARK7 -0.51 -8.13 -0.31 2.24e-15 Inflammatory bowel disease; BRCA cis rs11098499 0.863 rs3775845 chr4:120432447 T/C cg09307838 chr4:120376055 NA 0.7 14.18 0.49 7.37e-40 Corneal astigmatism; BRCA trans rs11098499 0.739 rs9884728 chr4:120127079 C/T cg25214090 chr10:38739885 LOC399744 -0.46 -9.84 -0.36 2.29e-21 Corneal astigmatism; BRCA cis rs7666738 0.830 rs1426670 chr4:98923572 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs1568889 0.838 rs11030206 chr11:28099747 C/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.11 0.62 4.67e-70 Bipolar disorder; BRCA cis rs1129187 0.967 rs3805951 chr6:42937176 C/A cg21280719 chr6:42927975 GNMT -0.31 -13.09 -0.46 7.62e-35 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2243480 0.803 rs423187 chr7:65509499 G/C cg18252515 chr7:66147081 NA -0.98 -13.81 -0.48 3.74e-38 Diabetic kidney disease; BRCA cis rs9443645 0.901 rs9361466 chr6:79618352 T/C cg18132916 chr6:79620363 NA -0.47 -10.59 -0.39 3.01e-24 Intelligence (multi-trait analysis); BRCA cis rs6582630 0.555 rs7294313 chr12:38323603 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.95 -0.37 8.91e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs10751667 0.666 rs10794354 chr11:954615 A/T ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.17e-52 Alzheimer's disease (late onset); BRCA cis rs6860806 0.507 rs270606 chr5:131650867 A/G cg11843238 chr5:131593191 PDLIM4 0.36 7.97 0.3 7.15e-15 Breast cancer; BRCA cis rs12477438 0.520 rs6717723 chr2:99756930 T/C cg08885076 chr2:99613938 TSGA10 0.44 10.29 0.38 4.44e-23 Chronic sinus infection; BRCA cis rs6142102 0.961 rs6119447 chr20:32668576 A/G cg24642439 chr20:33292090 TP53INP2 0.4 7.86 0.3 1.59e-14 Skin pigmentation; BRCA cis rs6088580 0.634 rs4142007 chr20:32990050 G/T cg08999081 chr20:33150536 PIGU -0.44 -12.28 -0.44 2.85e-31 Glomerular filtration rate (creatinine); BRCA cis rs3784262 0.692 rs12907125 chr15:58282621 C/A cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.85 -0.36 2.02e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs2386661 0.547 rs11259582 chr10:5646767 C/T cg17085576 chr10:5658249 NA -0.33 -8.18 -0.31 1.5e-15 Breast cancer; BRCA cis rs4722166 0.695 rs6946509 chr7:22809490 T/C cg05472934 chr7:22766657 IL6 0.5 12.99 0.46 2.02e-34 Lung cancer; BRCA cis rs67311347 1.000 rs7641495 chr3:40494690 T/C cg09455208 chr3:40491958 NA -0.48 -11.8 -0.42 3.16e-29 Renal cell carcinoma; BRCA cis rs61008539 0.893 rs4721502 chr7:862186 A/G cg00934597 chr7:893267 UNC84A -0.52 -11.53 -0.41 4.59e-28 Perceived unattractiveness to mosquitoes; BRCA cis rs4727027 0.901 rs1137432 chr7:148801658 C/T cg12479418 chr7:148823350 ZNF425;ZNF398 0.52 10.74 0.39 7.19e-25 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs9467773 1.000 rs6940188 chr6:26562029 G/C cg11502198 chr6:26597334 ABT1 0.48 9.67 0.36 1.02e-20 Intelligence (multi-trait analysis); BRCA cis rs4665809 1.000 rs6720314 chr2:26334852 G/A cg22920501 chr2:26401640 FAM59B -0.81 -13.17 -0.46 3.36e-35 Gut microbiome composition (summer); BRCA cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.92e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs11190604 1.000 rs11190597 chr10:102293676 A/T cg07080220 chr10:102295463 HIF1AN 0.63 14.82 0.51 6.32e-43 Palmitoleic acid (16:1n-7) levels; BRCA cis rs477895 0.653 rs34113693 chr11:63900123 G/T cg05016508 chr11:63871570 FLRT1;MACROD1 0.48 8.5 0.32 1.33e-16 Mean platelet volume; BRCA cis rs7618501 0.603 rs72942333 chr3:49986118 T/C cg24308560 chr3:49941425 MST1R -0.4 -8.57 -0.32 7.82e-17 Intelligence (multi-trait analysis); BRCA cis rs11711311 1.000 rs9865965 chr3:113450495 C/T cg15478005 chr3:113465772 ATP6V1A;NAA50 0.4 10.69 0.39 1.24e-24 IgG glycosylation; BRCA cis rs7178424 1.000 rs893158 chr15:62378608 G/A cg00456672 chr15:62358751 C2CD4A -0.35 -8.29 -0.31 6.74e-16 Height; BRCA cis rs9393777 0.513 rs1104871 chr6:26665235 T/G cg12292205 chr6:26970375 C6orf41 -0.48 -8.25 -0.31 8.81e-16 Intelligence (multi-trait analysis); BRCA cis rs2011503 0.882 rs10423874 chr19:19359500 C/G cg11584989 chr19:19387371 SF4 0.55 12.25 0.44 3.95e-31 Bipolar disorder; BRCA cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg12310025 chr6:25882481 NA -0.68 -16.23 -0.54 7.51e-50 Intelligence (multi-trait analysis); BRCA trans rs1493916 1.000 rs4799729 chr18:31393521 C/T cg15819921 chr19:927150 ARID3A 0.5 9.6 0.36 1.72e-20 Life satisfaction; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -11.23 -0.41 7.96e-27 Longevity;Endometriosis; BRCA cis rs7727544 0.716 rs72793283 chr5:131566941 G/A cg14196790 chr5:131705035 SLC22A5 0.4 10.04 0.37 3.84e-22 Blood metabolite levels; BRCA cis rs67460515 0.596 rs4856700 chr3:160922951 A/C cg17135325 chr3:160939158 NMD3 0.45 8.43 0.32 2.25e-16 Parkinson's disease; BRCA cis rs7809615 0.901 rs6947974 chr7:99156506 G/A cg12290671 chr7:99195819 NA -0.5 -8.7 -0.33 2.82e-17 Blood metabolite ratios; BRCA cis rs2304069 1.000 rs2304069 chr5:149406733 G/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.68 14.66 0.5 3.6e-42 HIV-1 control; BRCA cis rs763121 0.853 rs6519120 chr22:38991393 A/C cg21395723 chr22:39101663 GTPBP1 -0.37 -7.99 -0.3 6.53e-15 Menopause (age at onset); BRCA trans rs1941687 0.509 rs6507060 chr18:31322278 C/T cg27147174 chr7:100797783 AP1S1 0.46 9.13 0.34 8.99e-19 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs736408 0.648 rs3774355 chr3:52817778 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.43 0.35 7.15e-20 Bipolar disorder; BRCA cis rs40363 0.645 rs250630 chr16:3524242 C/T cg22508957 chr16:3507546 NAT15 0.47 11.42 0.41 1.31e-27 Tuberculosis; BRCA cis rs4949448 1.000 rs4949448 chr1:32062066 A/C cg13919466 chr1:32135498 COL16A1 0.26 8.24 0.31 9.57e-16 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.618 rs7579199 chr2:26266496 G/A cg26314531 chr2:26401878 FAM59B -0.63 -10.78 -0.39 5.13e-25 Gut microbiome composition (summer); BRCA cis rs12618769 0.597 rs961242 chr2:99138979 G/A cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA cis rs600231 0.508 rs35292734 chr11:65227700 C/T cg01292856 chr11:65242576 NA 0.65 14.2 0.49 5.92e-40 Bone mineral density; BRCA cis rs7772486 0.790 rs2814879 chr6:146201743 T/C cg23711669 chr6:146136114 FBXO30 0.71 17.08 0.56 3.5e-54 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.591 rs189094 chr21:44932017 A/G cg04455712 chr21:45112962 RRP1B 0.36 8.6 0.32 5.94e-17 Mean corpuscular volume; BRCA cis rs9487051 0.839 rs13196590 chr6:109561918 T/C cg01475377 chr6:109611718 NA -0.41 -9.63 -0.36 1.36e-20 Reticulocyte fraction of red cells; BRCA cis rs3768617 0.510 rs4651143 chr1:183097398 A/G ch.1.3577855R chr1:183094577 LAMC1 0.66 17.13 0.56 2.16e-54 Fuchs's corneal dystrophy; BRCA cis rs2762353 0.779 rs3799352 chr6:25822620 C/T cg03264133 chr6:25882463 NA -0.52 -11.75 -0.42 5.15e-29 Blood metabolite levels; BRCA cis rs875971 1.000 rs811880 chr7:65818646 T/C cg18876405 chr7:65276391 NA 0.55 13.2 0.46 2.49e-35 Aortic root size; BRCA cis rs13191362 0.507 rs2849527 chr6:163117932 G/T cg21926612 chr6:163149169 PACRG;PARK2 0.53 10.73 0.39 7.97e-25 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8072100 0.967 rs4793842 chr17:45671506 G/A cg25173405 chr17:45401733 C17orf57 0.49 9.94 0.37 9.55e-22 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg18765753 chr7:1198926 ZFAND2A -0.37 -8.73 -0.33 2.19e-17 Longevity;Endometriosis; BRCA cis rs912057 0.671 rs1294433 chr6:6745163 G/A cg06612196 chr6:6737390 NA 0.46 10.68 0.39 1.32e-24 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs1059312 1.000 rs2291350 chr12:129283711 G/A cg09035930 chr12:129282057 SLC15A4 0.58 17.38 0.57 1.09e-55 Systemic lupus erythematosus; BRCA cis rs10489202 0.608 rs6657019 chr1:168079669 T/C cg24449463 chr1:168025552 DCAF6 -0.46 -15.1 -0.51 2.77e-44 Schizophrenia; BRCA cis rs365132 0.791 rs55954117 chr5:176454075 A/G cg16309518 chr5:176445507 NA -0.39 -9.29 -0.34 2.45e-19 Menarche and menopause (age at onset);Menopause (age at onset); BRCA cis rs17270561 0.609 rs4711103 chr6:25742224 C/T cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA cis rs2255932 1.000 rs2662767 chr3:183212393 A/G cg12326526 chr3:183209927 KLHL6 0.46 7.84 0.3 1.87e-14 Interleukin-1-beta levels; BRCA cis rs2304069 0.954 rs10045945 chr5:149419297 C/T cg22760475 chr5:149380129 HMGXB3;TIGD6 0.82 16.66 0.55 5.33e-52 HIV-1 control; BRCA cis rs274567 0.501 rs2631368 chr5:131705297 T/G cg24060327 chr5:131705240 SLC22A5 0.65 12.88 0.45 6.76e-34 Blood metabolite levels; BRCA cis rs7552404 1.000 rs4949875 chr1:76173080 G/A cg10523679 chr1:76189770 ACADM 0.75 15.64 0.53 6.6e-47 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2836974 0.583 rs2410124 chr21:40704760 C/G cg22974920 chr21:40686053 BRWD1 -0.39 -8.57 -0.32 7.74e-17 Cognitive function; BRCA cis rs3741404 0.895 rs2429455 chr11:63995302 C/G cg18225595 chr11:63971243 STIP1 0.47 11.17 0.4 1.36e-26 Platelet count; BRCA cis rs4478858 0.647 rs11581476 chr1:31717675 C/T cg00250761 chr1:31883323 NA -0.31 -8.16 -0.31 1.74e-15 Alcohol dependence; BRCA cis rs2576037 0.583 rs644731 chr18:44426877 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.54 -11.14 -0.4 1.77e-26 Personality dimensions; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2599510 0.811 rs176413 chr2:32646847 G/A cg02381751 chr2:32503542 YIPF4 -0.42 -8.35 -0.31 4.28e-16 Interleukin-18 levels; BRCA cis rs1862618 0.671 rs2591956 chr5:56244604 G/A cg24531977 chr5:56204891 C5orf35 0.71 15.53 0.52 2.24e-46 Initial pursuit acceleration; BRCA cis rs9287719 0.967 rs6733416 chr2:10738684 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs798554 0.797 rs798486 chr7:2803037 A/G cg04166393 chr7:2884313 GNA12 0.48 9.08 0.34 1.35e-18 Height; BRCA cis rs11577318 0.853 rs2276712 chr1:26627478 T/C cg04990556 chr1:26633338 UBXN11 -0.47 -9.26 -0.34 2.98e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs3820928 0.874 rs1917125 chr2:227798981 G/A cg11843606 chr2:227700838 RHBDD1 -0.4 -8.84 -0.33 9.34e-18 Pulmonary function; BRCA cis rs13108904 0.967 rs62293658 chr4:1276416 T/C cg05665937 chr4:1216051 CTBP1 -0.38 -8.26 -0.31 8.12e-16 Obesity-related traits; BRCA cis rs801193 0.591 rs9986881 chr7:66173040 A/G cg11764359 chr7:65958608 NA 0.41 7.86 0.3 1.7e-14 Aortic root size; BRCA trans rs7939886 0.920 rs17150095 chr11:55902900 A/G cg15704280 chr7:45808275 SEPT13 0.63 7.84 0.3 1.88e-14 Myopia (pathological); BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 20.53 0.63 2.65e-72 Platelet count; BRCA cis rs4713118 0.824 rs7759217 chr6:27730463 A/G cg08798685 chr6:27730294 NA -0.41 -8.03 -0.3 4.78e-15 Parkinson's disease; BRCA cis rs10193935 1.000 rs62144748 chr2:42419468 C/T cg27598129 chr2:42591480 NA -0.93 -15.0 -0.51 8.94e-44 Colonoscopy-negative controls vs population controls; BRCA cis rs17345786 1.000 rs11715368 chr3:101336380 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 13.16 0.46 3.58e-35 Colonoscopy-negative controls vs population controls; BRCA trans rs2562456 0.874 rs2562417 chr19:21711202 T/C cg25042112 chr7:64838748 ZNF92 0.46 8.34 0.31 4.53e-16 Pain; BRCA cis rs2576037 0.501 rs557661 chr18:44365657 A/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.55 -11.27 -0.41 5.62e-27 Personality dimensions; BRCA cis rs796364 0.512 rs1653290 chr2:201078165 A/T cg23649088 chr2:200775458 C2orf69 0.53 8.9 0.33 5.71e-18 Schizophrenia; BRCA cis rs12318506 1.000 rs12318506 chr12:75718423 G/T cg04728562 chr12:75699417 CAPS2 -0.64 -9.2 -0.34 5.1e-19 Coronary artery calcification; BRCA cis rs60843830 0.550 rs300751 chr2:209063 A/C cg25945732 chr2:264204 ACP1;SH3YL1 0.45 9.71 0.36 7.13e-21 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs881375 0.967 rs2416806 chr9:123690292 G/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.89 0.4 1.82e-25 Rheumatoid arthritis; BRCA cis rs1129187 0.755 rs9471986 chr6:42944127 A/G cg05552183 chr6:42928497 GNMT 0.68 15.39 0.52 1.11e-45 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs561341 1.000 rs55978022 chr17:30275937 T/C cg00745463 chr17:30367425 LRRC37B -0.61 -9.82 -0.36 2.81e-21 Hip circumference adjusted for BMI; BRCA cis rs765787 0.530 rs12904331 chr15:45518293 C/T cg25801113 chr15:45476975 SHF -0.34 -8.33 -0.31 4.87e-16 Uric acid levels; BRCA cis rs73086581 1.000 rs56069856 chr20:3965709 A/C cg02187196 chr20:3869020 PANK2 0.53 9.48 0.35 4.73e-20 Response to antidepressants in depression; BRCA cis rs425277 1.000 rs262667 chr1:2082722 T/C cg24578937 chr1:2090814 PRKCZ 0.58 17.86 0.58 3.76e-58 Height; BRCA cis rs7772486 0.875 rs2814875 chr6:146305810 G/A cg23711669 chr6:146136114 FBXO30 0.74 16.67 0.55 4.5e-52 Lobe attachment (rater-scored or self-reported); BRCA cis rs6594713 0.679 rs9326890 chr5:112859994 C/T cg12552261 chr5:112820674 MCC 0.48 8.03 0.3 4.85e-15 Brain cytoarchitecture; BRCA cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg11663144 chr21:46675770 NA -0.62 -14.32 -0.49 1.53e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7572733 0.534 rs1518365 chr2:198809410 T/C cg00792783 chr2:198669748 PLCL1 0.45 9.94 0.37 9.5e-22 Dermatomyositis; BRCA cis rs6565180 1.000 rs11646130 chr16:30376959 T/C cg17640201 chr16:30407289 ZNF48 -0.74 -16.02 -0.54 8.68e-49 Tonsillectomy; BRCA cis rs2070488 0.775 rs2051214 chr3:38560303 C/A cg24069376 chr3:38537580 EXOG -0.29 -7.97 -0.3 7.27e-15 Electrocardiographic conduction measures; BRCA cis rs2075371 0.829 rs11770764 chr7:134003308 T/C cg20476274 chr7:133979776 SLC35B4 0.61 15.06 0.51 4.51e-44 Mean platelet volume; BRCA cis rs72781680 0.898 rs72786277 chr2:24062818 T/G cg20701182 chr2:24300061 SF3B14 0.58 9.04 0.34 1.86e-18 Lymphocyte counts; BRCA cis rs3761847 0.593 rs10985140 chr9:123822837 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.4 8.34 0.31 4.5e-16 Rheumatoid arthritis; BRCA cis rs6120849 0.901 rs6060270 chr20:33736814 G/T cg24642439 chr20:33292090 TP53INP2 0.48 8.52 0.32 1.18e-16 Protein C levels; BRCA cis rs4727027 0.899 rs7791496 chr7:148863674 C/G cg23583168 chr7:148888333 NA -0.86 -20.12 -0.62 4.19e-70 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg04944784 chr2:26401820 FAM59B -0.92 -15.22 -0.52 7.33e-45 Gut microbiome composition (summer); BRCA cis rs2011503 0.943 rs756997 chr19:19467085 G/C cg15839431 chr19:19639596 YJEFN3 0.41 8.96 0.33 3.58e-18 Bipolar disorder; BRCA cis rs6089829 0.962 rs11086151 chr20:61664644 C/T cg08564027 chr20:61660810 NA 0.85 22.97 0.67 1.42e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs4853012 0.887 rs77148265 chr2:74339519 C/T cg01017244 chr2:74357527 NA 0.6 12.4 0.44 8.95e-32 Gestational age at birth (maternal effect); BRCA cis rs910316 0.663 rs175034 chr14:75463687 T/G cg23033748 chr14:75592666 NEK9 -0.33 -7.9 -0.3 1.26e-14 Height; BRCA trans rs17685 0.753 rs6953665 chr7:75769049 C/T cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs7552404 0.731 rs12090849 chr1:76400261 A/G cg03433033 chr1:76189801 ACADM 0.58 11.29 0.41 4.65e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs1348850 0.567 rs3770012 chr2:178538023 A/G cg22681709 chr2:178499509 PDE11A 0.42 9.01 0.34 2.29e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs7945705 0.782 rs2742545 chr11:8884308 C/G cg12365402 chr11:9010492 NRIP3 -0.39 -9.05 -0.34 1.69e-18 Hemoglobin concentration; BRCA cis rs2019137 0.560 rs10206269 chr2:113990393 C/A cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.77 17.11 0.56 2.51e-54 Lymphocyte counts; BRCA cis rs57590327 0.555 rs7634258 chr3:81799100 T/C cg07356753 chr3:81810745 GBE1 -0.47 -11.24 -0.41 7.08e-27 Extraversion; BRCA cis rs6545883 0.524 rs2463101 chr2:61574422 G/C cg15711740 chr2:61764176 XPO1 0.33 8.03 0.3 4.65e-15 Tuberculosis; BRCA cis rs7246657 0.639 rs12459015 chr19:38083189 T/A cg23950597 chr19:37808831 NA -0.5 -8.64 -0.32 4.63e-17 Coronary artery calcification; BRCA cis rs13191362 1.000 rs68045643 chr6:163029709 A/G cg21926612 chr6:163149169 PACRG;PARK2 0.77 12.65 0.45 6.99e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs62103177 0.564 rs11874805 chr18:77697110 T/C cg05926928 chr17:57297772 GDPD1 1.0 13.63 0.47 2.68e-37 Opioid sensitivity; BRCA cis rs35306767 0.761 rs12773961 chr10:1013215 C/G cg10556349 chr10:835070 NA 0.63 8.79 0.33 1.36e-17 Eosinophil percentage of granulocytes; BRCA cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg08000102 chr2:233561755 GIGYF2 0.63 13.88 0.48 1.8e-38 Coronary artery disease; BRCA cis rs4689592 0.554 rs3822270 chr4:7069804 C/A cg02503808 chr4:7069936 GRPEL1 0.8 18.42 0.59 4.24e-61 Monocyte percentage of white cells; BRCA trans rs7824557 0.767 rs3808509 chr8:11163256 G/T cg15556689 chr8:8085844 FLJ10661 0.38 8.84 0.33 9.02e-18 Retinal vascular caliber; BRCA cis rs736408 0.688 rs2239551 chr3:52818579 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.44 -9.39 -0.35 1.01e-19 Bipolar disorder; BRCA trans rs11098499 0.865 rs4507344 chr4:120307485 C/A cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.09 0.3 3e-15 Corneal astigmatism; BRCA cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg02297831 chr4:17616191 MED28 0.37 8.5 0.32 1.34e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs881375 0.900 rs1008383 chr9:123683579 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.43 0.32 2.27e-16 Rheumatoid arthritis; BRCA cis rs73198271 0.562 rs3827810 chr8:8659040 T/G cg01851573 chr8:8652454 MFHAS1 0.49 7.98 0.3 6.91e-15 Bone ultrasound measurement (broadband ultrasound attenuation); BRCA cis rs427394 0.582 rs274667 chr5:6710771 A/G cg10857441 chr5:6722123 POLS 0.3 9.51 0.35 3.72e-20 Menopause (age at onset); BRCA cis rs28735056 0.967 rs4799092 chr18:77608203 C/G cg20368463 chr18:77673604 PQLC1 -0.35 -8.2 -0.31 1.32e-15 Schizophrenia; BRCA cis rs68170813 0.559 rs4730231 chr7:106942039 G/C cg02696742 chr7:106810147 HBP1 -0.53 -8.72 -0.33 2.33e-17 Coronary artery disease; BRCA cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg06636001 chr8:8085503 FLJ10661 0.7 15.87 0.53 4.66e-48 Mood instability; BRCA cis rs425277 1.000 rs262651 chr1:2091397 A/G cg24578937 chr1:2090814 PRKCZ 0.58 17.99 0.58 7.63e-59 Height; BRCA cis rs1707322 0.506 rs2991983 chr1:46079391 T/C cg06784218 chr1:46089804 CCDC17 -0.53 -12.75 -0.45 2.45e-33 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12477438 0.520 rs11890338 chr2:99767868 C/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.87 28.06 0.74 1.58e-113 Chronic sinus infection; BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg13047869 chr3:10149882 C3orf24 0.61 13.07 0.46 9.09e-35 Alzheimer's disease; BRCA cis rs10256972 0.758 rs2280724 chr7:1064720 A/G cg16145915 chr7:1198662 ZFAND2A -0.47 -10.78 -0.39 5.15e-25 Longevity;Endometriosis; BRCA cis rs9611565 0.512 rs139561 chr22:42195410 C/T cg03806693 chr22:41940476 POLR3H 1.09 19.35 0.61 5.17e-66 Vitiligo; BRCA cis rs10129255 0.500 rs2105991 chr14:107138039 C/G cg07958169 chr14:107095056 NA -0.38 -8.15 -0.31 1.97e-15 Kawasaki disease; BRCA cis rs735396 1.000 rs1169310 chr12:121439433 G/A cg02403541 chr12:121454288 C12orf43 0.53 9.96 0.37 7.72e-22 N-glycan levels; BRCA cis rs3820928 0.874 rs6707265 chr2:227849255 T/A cg11843606 chr2:227700838 RHBDD1 -0.38 -8.29 -0.31 6.71e-16 Pulmonary function; BRCA cis rs9308433 0.505 rs6695148 chr1:214497861 G/T cg06198575 chr1:214491504 SMYD2 0.57 12.27 0.44 3.04e-31 IgG glycosylation; BRCA cis rs2204008 0.748 rs11180579 chr12:38237830 A/G cg13010199 chr12:38710504 ALG10B 0.5 9.98 0.37 6.83e-22 Bladder cancer; BRCA cis rs10504229 0.683 rs6999984 chr8:58115079 G/A cg08219700 chr8:58056026 NA 0.44 8.0 0.3 5.74e-15 Developmental language disorder (linguistic errors); BRCA cis rs4566357 0.615 rs10184991 chr2:227916533 G/A cg11843606 chr2:227700838 RHBDD1 -0.43 -9.55 -0.35 2.65e-20 Coronary artery disease; BRCA cis rs7666738 0.830 rs969048 chr4:98988921 T/C cg17366294 chr4:99064904 C4orf37 0.45 10.64 0.39 1.81e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg23285459 chr7:2802560 GNA12 -0.33 -8.04 -0.3 4.28e-15 Height; BRCA cis rs4642101 0.824 rs3889515 chr3:12844112 G/C cg24848339 chr3:12840334 CAND2 0.41 10.6 0.39 2.8e-24 QRS complex (12-leadsum); BRCA cis rs6951245 1.000 rs78158942 chr7:1090440 G/T cg08132940 chr7:1081526 C7orf50 -0.6 -8.85 -0.33 8.67e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs798554 0.757 rs1182187 chr7:2870454 T/G cg19346786 chr7:2764209 NA -0.32 -9.12 -0.34 9.99e-19 Height; BRCA cis rs933688 0.536 rs332537 chr5:90794973 C/T cg12630606 chr5:90679528 LOC100129716;ARRDC3 -0.79 -13.67 -0.48 1.6e-37 Smoking behavior; BRCA cis rs4363385 0.818 rs559236 chr1:153010510 T/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA trans rs8002861 0.935 rs1822969 chr13:44418164 G/A cg17145862 chr1:211918768 LPGAT1 0.68 17.84 0.58 4.6e-58 Leprosy; BRCA cis rs7493 0.950 rs17880101 chr7:95031457 A/T cg21856205 chr7:94953877 PON1 -0.37 -7.93 -0.3 9.67e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10752881 1.000 rs10797807 chr1:182978873 T/C ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs10267417 0.603 rs10224041 chr7:19903837 T/C cg07541023 chr7:19748670 TWISTNB 0.45 8.23 0.31 1.09e-15 Night sleep phenotypes; BRCA cis rs651907 0.557 rs3806653 chr3:101396972 T/C cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.75 -0.33 1.82e-17 Colorectal cancer; BRCA cis rs12701220 0.553 rs9639882 chr7:1133731 G/A cg00990874 chr7:1149470 C7orf50 -0.6 -12.02 -0.43 3.95e-30 Bronchopulmonary dysplasia; BRCA cis rs11719291 0.915 rs9834996 chr3:48754877 G/T cg07636037 chr3:49044803 WDR6 -0.58 -8.0 -0.3 6e-15 Cognitive function; BRCA cis rs9814567 0.806 rs1880375 chr3:134322163 C/A cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.84 -0.3 1.86e-14 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11098499 0.863 rs13140391 chr4:120503437 A/G cg09307838 chr4:120376055 NA 0.69 13.91 0.48 1.24e-38 Corneal astigmatism; BRCA cis rs2204008 0.837 rs1842599 chr12:37986081 G/A cg26384229 chr12:38710491 ALG10B -0.58 -13.44 -0.47 1.91e-36 Bladder cancer; BRCA cis rs9393692 0.645 rs766406 chr6:26319588 G/T cg00631329 chr6:26305371 NA -0.57 -15.8 -0.53 1.09e-47 Educational attainment; BRCA cis rs11971779 0.793 rs11543827 chr7:139032693 G/A cg07862535 chr7:139043722 LUC7L2 0.45 12.05 0.43 2.88e-30 Diisocyanate-induced asthma; BRCA cis rs7772486 0.720 rs9403757 chr6:146261271 C/T cg05347473 chr6:146136440 FBXO30 -0.4 -7.85 -0.3 1.74e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.807 rs2838325 chr21:45014284 A/T cg01579765 chr21:45077557 HSF2BP 0.34 9.13 0.34 8.7e-19 Mean corpuscular volume; BRCA cis rs10464366 0.544 rs953874 chr7:39147916 G/A cg18850127 chr7:39170497 POU6F2 0.48 10.86 0.39 2.48e-25 IgG glycosylation; BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.46 0.44 4.75e-32 Platelet count; BRCA cis rs7666738 0.830 rs13125432 chr4:98961253 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.3e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1218582 0.772 rs10796934 chr1:154849479 C/G cg24250549 chr1:154909240 PMVK 0.71 18.24 0.59 3.82e-60 Prostate cancer; BRCA cis rs7191700 0.509 rs416603 chr16:11364079 A/T cg00044050 chr16:11439710 C16orf75 -0.35 -8.44 -0.32 2.09e-16 Multiple sclerosis; BRCA cis rs10504229 0.683 rs6982990 chr8:58115275 C/T cg20607798 chr8:58055168 NA -0.46 -8.02 -0.3 5.07e-15 Developmental language disorder (linguistic errors); BRCA cis rs7582180 0.652 rs12997725 chr2:100935136 A/G cg14675211 chr2:100938903 LONRF2 0.52 12.14 0.43 1.12e-30 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs75855890 chr2:27625005 G/T cg21747090 chr2:27597821 SNX17 -0.37 -8.0 -0.3 5.8e-15 Total body bone mineral density; BRCA cis rs6840360 0.509 rs62327273 chr4:152547594 A/G cg22705602 chr4:152727874 NA -0.34 -8.54 -0.32 9.91e-17 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.634 rs1205344 chr20:32918298 G/A cg06115741 chr20:33292138 TP53INP2 -0.36 -7.95 -0.3 8.64e-15 Glomerular filtration rate (creatinine); BRCA cis rs7772486 0.905 rs9373486 chr6:146446024 C/G cg13319975 chr6:146136371 FBXO30 0.36 8.07 0.3 3.51e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs7246657 0.663 rs9304568 chr19:38054508 C/A cg14683738 chr19:37701593 ZNF585B 0.47 8.07 0.3 3.58e-15 Coronary artery calcification; BRCA cis rs9486719 1.000 rs2971608 chr6:97039757 T/C cg06623918 chr6:96969491 KIAA0776 -0.75 -16.81 -0.55 9.2e-53 Migraine;Coronary artery disease; BRCA cis rs9660180 0.620 rs34298494 chr1:1663402 A/C cg13866156 chr1:1669148 SLC35E2 0.49 10.28 0.38 4.69e-23 Body mass index; BRCA cis rs9467773 0.620 rs2504599 chr6:26641060 C/T cg09904177 chr6:26538194 HMGN4 0.47 14.7 0.5 2.33e-42 Intelligence (multi-trait analysis); BRCA cis rs11190604 1.000 rs1080698 chr10:102295114 G/T cg07080220 chr10:102295463 HIF1AN 0.62 13.79 0.48 4.48e-38 Palmitoleic acid (16:1n-7) levels; BRCA cis rs312273 0.806 rs10879417 chr12:41347940 T/C cg17827154 chr12:41323612 CNTN1 -0.42 -10.98 -0.4 8.04e-26 Bipolar disorder; BRCA cis rs4077515 0.839 rs3812563 chr9:139271106 A/G cg14019695 chr9:139328340 INPP5E 0.31 8.1 0.31 2.73e-15 Ulcerative colitis;IgA nephropathy;Inflammatory bowel disease;Crohn's disease; BRCA cis rs74417235 0.528 rs9324789 chr5:154074362 C/T cg08754654 chr5:154026448 NA -0.35 -9.06 -0.34 1.59e-18 Reticulocyte count;Reticulocyte fraction of red cells;Mean corpuscular hemoglobin concentration; BRCA cis rs713587 1.000 rs713587 chr2:25158281 C/T cg01884057 chr2:25150051 NA 0.32 8.46 0.32 1.88e-16 Body mass index in non-asthmatics; BRCA cis rs4561483 0.832 rs33645 chr16:11985201 T/C cg08843971 chr16:11963173 GSPT1 -0.53 -12.02 -0.43 3.95e-30 Testicular germ cell tumor; BRCA cis rs59574136 1 rs59574136 chr7:2036460 T/C cg18279126 chr7:2041391 MAD1L1 0.4 8.88 0.33 6.47e-18 Autism spectrum disorder or schizophrenia; BRCA cis rs10504229 0.683 rs10504221 chr8:58140256 A/G cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs13046373 0.535 rs13051135 chr21:32005278 G/A cg16431978 chr21:31797932 KRTAP13-3 0.36 9.02 0.34 2.22e-18 HDL cholesterol; BRCA trans rs1814175 0.566 rs1811673 chr11:49602134 A/G cg03929089 chr4:120376271 NA -0.67 -13.39 -0.47 3.19e-36 Height; BRCA cis rs2839186 1.000 rs2839181 chr21:47685939 A/G cg13012494 chr21:47604986 C21orf56 0.41 8.4 0.32 2.81e-16 Testicular germ cell tumor; BRCA cis rs769267 0.965 rs8103496 chr19:19386015 A/G cg11584989 chr19:19387371 SF4 0.3 7.85 0.3 1.71e-14 Tonsillectomy; BRCA cis rs9359856 0.623 rs1179907 chr6:90324849 A/G cg13799429 chr6:90582589 CASP8AP2 -0.53 -8.65 -0.32 4.01e-17 Bipolar disorder; BRCA cis rs12497850 0.931 rs4974080 chr3:49030828 A/C cg06212747 chr3:49208901 KLHDC8B 0.48 9.72 0.36 6.24e-21 Parkinson's disease; BRCA cis rs7666738 0.716 rs35195511 chr4:98859660 G/A cg05340658 chr4:99064831 C4orf37 0.62 14.8 0.51 8.06e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs1691799 0.899 rs903589 chr12:66745835 C/T cg16791601 chr12:66731901 HELB -0.63 -17.05 -0.56 5.45e-54 White blood cell count (basophil); BRCA cis rs2481665 0.772 rs6661862 chr1:62534854 A/C cg18591186 chr1:62594603 INADL 0.54 11.72 0.42 7.14e-29 BMI in non-smokers;BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs881375 0.967 rs10739580 chr9:123695282 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.48 0.32 1.53e-16 Rheumatoid arthritis; BRCA cis rs2243480 1.000 rs7792391 chr7:65773429 A/G cg18252515 chr7:66147081 NA 1.06 15.89 0.53 3.65e-48 Diabetic kidney disease; BRCA cis rs4819052 0.851 rs4819049 chr21:46673086 C/G cg06618935 chr21:46677482 NA -0.38 -8.51 -0.32 1.28e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1862618 0.853 rs2113079 chr5:56157951 A/G cg12311346 chr5:56204834 C5orf35 -0.82 -16.27 -0.54 4.48e-50 Initial pursuit acceleration; BRCA cis rs7762018 1.000 rs6923339 chr6:170128033 T/A cg19338460 chr6:170058176 WDR27 -0.45 -7.85 -0.3 1.72e-14 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs11676348 0.846 rs11677534 chr2:219007060 T/C cg20019365 chr2:219134978 PNKD;AAMP -0.38 -8.0 -0.3 5.94e-15 Ulcerative colitis; BRCA cis rs4563143 0.514 rs112540771 chr19:29316100 C/T cg12667521 chr19:29218732 NA 0.47 7.89 0.3 1.35e-14 Methadone dose in opioid dependence; BRCA cis rs7811142 0.666 rs28401739 chr7:99905684 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.8 14.01 0.48 4.26e-39 Platelet count; BRCA cis rs7586879 0.639 rs6545776 chr2:25099357 A/C cg01884057 chr2:25150051 NA 0.3 7.82 0.3 2.21e-14 Body mass index; BRCA cis rs4664304 1.000 rs6735923 chr2:160769588 A/G cg02280532 chr2:160761244 LY75 -0.4 -8.77 -0.33 1.6e-17 Crohn's disease;Inflammatory bowel disease; BRCA trans rs61931739 0.534 rs11052991 chr12:34059018 G/T cg26384229 chr12:38710491 ALG10B -0.56 -12.0 -0.43 4.67e-30 Morning vs. evening chronotype; BRCA cis rs220324 0.688 rs2236703 chr21:43562525 G/A cg09727148 chr21:43560719 UMODL1 0.48 8.33 0.31 4.88e-16 Idiopathic osteonecrosis of the femoral head; BRCA cis rs4332037 0.707 rs62435132 chr7:1891315 C/T cg23422044 chr7:1970798 MAD1L1 -0.59 -10.55 -0.39 4.32e-24 Bipolar disorder; BRCA cis rs3771570 1.000 rs73004382 chr2:242382192 C/T cg21155796 chr2:242212141 HDLBP 0.61 9.34 0.35 1.6e-19 Prostate cancer; BRCA cis rs2836950 0.501 rs2056844 chr21:40670460 G/C cg11644478 chr21:40555479 PSMG1 -0.49 -10.42 -0.38 1.34e-23 Menarche (age at onset); BRCA cis rs7811142 1.000 rs76913697 chr7:100002772 A/G cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.19 22.69 0.67 4.49e-84 Platelet count; BRCA cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg02475777 chr4:1388615 CRIPAK 0.61 12.01 0.43 4.01e-30 Longevity; BRCA cis rs250677 0.617 rs166106 chr5:148447061 T/C cg23229984 chr5:148520753 ABLIM3 0.35 8.18 0.31 1.56e-15 Breast cancer; BRCA cis rs1707322 0.691 rs61784803 chr1:46179271 C/A cg06784218 chr1:46089804 CCDC17 -0.51 -12.23 -0.44 4.9e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs13118159 0.872 rs4974604 chr4:1345798 T/C cg20887711 chr4:1340912 KIAA1530 0.36 8.53 0.32 1.03e-16 Longevity; BRCA trans rs75804782 0.641 rs2340870 chr2:239356026 C/T cg01134436 chr17:81009848 B3GNTL1 0.77 9.91 0.36 1.25e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs17601876 0.679 rs11636403 chr15:51548744 A/G cg19946085 chr15:51559439 CYP19A1 0.32 8.37 0.31 3.65e-16 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.68e-18 Motion sickness; BRCA cis rs7552404 0.727 rs2172507 chr1:76331320 A/G cg10523679 chr1:76189770 ACADM -0.57 -10.61 -0.39 2.5e-24 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs17539620 0.624 rs871069 chr6:154837578 A/C cg20019720 chr6:154832845 CNKSR3 0.52 10.31 0.38 3.64e-23 Lipoprotein (a) levels; BRCA trans rs61931739 0.500 rs11053268 chr12:34545121 T/C cg13010199 chr12:38710504 ALG10B 0.44 9.22 0.34 4.31e-19 Morning vs. evening chronotype; BRCA cis rs2033711 0.840 rs3764533 chr19:58929194 A/G cg26874164 chr19:58962979 ZNF324B 0.42 9.17 0.34 6.23e-19 Uric acid clearance; BRCA cis rs72781680 0.948 rs72781652 chr2:24213754 G/A cg08917208 chr2:24149416 ATAD2B 0.92 13.73 0.48 8.4e-38 Lymphocyte counts; BRCA cis rs1801251 0.963 rs13021246 chr2:233623111 T/C cg25237894 chr2:233734115 C2orf82 0.4 11.42 0.41 1.32e-27 Coronary artery disease; BRCA trans rs877282 0.945 rs11599043 chr10:777972 C/T cg22713356 chr15:30763199 NA 1.27 24.67 0.7 6.18e-95 Uric acid levels; BRCA cis rs8114671 0.836 rs1885114 chr20:33577361 A/G cg07148914 chr20:33460835 GGT7 -0.42 -8.99 -0.34 2.74e-18 Height; BRCA cis rs72781680 1.000 rs72796329 chr2:24141912 G/A cg20701182 chr2:24300061 SF3B14 0.58 9.14 0.34 7.93e-19 Lymphocyte counts; BRCA cis rs9815354 0.767 rs73087378 chr3:41936827 G/A cg03022575 chr3:42003672 ULK4 0.68 9.48 0.35 4.71e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs10193935 0.901 rs10189710 chr2:42573102 C/G cg27598129 chr2:42591480 NA -0.86 -14.02 -0.49 3.82e-39 Colonoscopy-negative controls vs population controls; BRCA cis rs61008539 0.821 rs10950789 chr7:897492 A/G cg00475322 chr7:917719 C7orf20 0.48 12.85 0.45 9.04e-34 Perceived unattractiveness to mosquitoes; BRCA cis rs7666738 0.830 rs1365458 chr4:98950961 C/T cg17366294 chr4:99064904 C4orf37 0.44 10.43 0.38 1.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs9443645 0.901 rs2174742 chr6:79610101 G/T cg09184832 chr6:79620586 NA -0.46 -10.07 -0.37 2.95e-22 Intelligence (multi-trait analysis); BRCA cis rs9311474 0.508 rs12629701 chr3:52619836 T/C cg05573699 chr3:52720067 GNL3;PBRM1 -0.33 -7.81 -0.3 2.41e-14 Electroencephalogram traits; BRCA cis rs17604090 0.775 rs76480599 chr7:29689180 A/G cg19413766 chr7:29689036 LOC646762 -0.5 -7.95 -0.3 8.71e-15 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA trans rs6598955 0.671 rs17163751 chr1:26568698 A/G cg07461501 chr17:79650226 HGS;ARL16 -0.68 -16.22 -0.54 8.55e-50 Obesity-related traits; BRCA cis rs1355223 0.583 rs1828298 chr11:34870439 A/G cg11058730 chr11:34937778 PDHX;APIP 0.67 15.55 0.52 1.82e-46 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs9463078 0.547 rs4714819 chr6:44735285 G/C cg25276700 chr6:44698697 NA 0.39 9.12 0.34 9.57e-19 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs10751667 1.000 rs7396798 chr11:970510 G/T cg06064525 chr11:970664 AP2A2 -0.33 -9.93 -0.37 1.03e-21 Alzheimer's disease (late onset); BRCA cis rs34172651 0.517 rs11642954 chr16:24824248 G/A cg04756594 chr16:24857601 SLC5A11 0.54 12.08 0.43 2.11e-30 Intelligence (multi-trait analysis); BRCA cis rs7833790 1.000 rs7834808 chr8:82704996 A/G cg17211192 chr8:82754475 SNX16 -0.64 -11.87 -0.43 1.67e-29 Diastolic blood pressure; BRCA cis rs703842 0.616 rs10783850 chr12:58229377 T/C cg04478727 chr12:58166393 METTL1;FAM119B 0.5 8.68 0.32 3.27e-17 Multiple sclerosis; BRCA cis rs6952808 0.689 rs12668156 chr7:2019875 G/A cg02951883 chr7:2050386 MAD1L1 -0.59 -13.37 -0.47 3.82e-36 Bipolar disorder and schizophrenia; BRCA cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg06238570 chr21:40685208 BRWD1 0.4 8.16 0.31 1.78e-15 Menarche (age at onset); BRCA trans rs7819412 0.594 rs17724226 chr8:10968926 C/T cg15556689 chr8:8085844 FLJ10661 -0.36 -9.54 -0.35 3.02e-20 Triglycerides; BRCA cis rs1712517 0.873 rs1891292 chr10:105001510 A/G cg05636881 chr10:105038444 INA -0.4 -9.35 -0.35 1.43e-19 Migraine; BRCA cis rs56399783 0.901 rs56007918 chr7:2826205 A/G cg19731401 chr7:2775893 GNA12 0.51 8.28 0.31 7.2e-16 Childhood ear infection; BRCA cis rs1371867 0.846 rs959022 chr8:101295992 T/A cg06636551 chr8:101224915 SPAG1 -0.38 -8.62 -0.32 5.27e-17 Atrioventricular conduction; BRCA cis rs7520050 0.966 rs12409773 chr1:46358831 A/G cg24296786 chr1:45957014 TESK2 0.43 9.66 0.36 1.06e-20 Red blood cell count;Reticulocyte count; BRCA trans rs2204008 0.744 rs12099650 chr12:38317140 C/G cg06521331 chr12:34319734 NA -0.46 -8.53 -0.32 1.08e-16 Bladder cancer; BRCA cis rs67478160 0.643 rs11847468 chr14:104220295 G/A cg08213375 chr14:104286397 PPP1R13B 0.64 18.05 0.58 3.53e-59 Schizophrenia; BRCA cis rs34375054 0.738 rs10846834 chr12:125625570 A/G cg25124228 chr12:125621409 AACS -0.48 -10.91 -0.4 1.61e-25 Post bronchodilator FEV1/FVC ratio; BRCA cis rs2880765 0.566 rs55899824 chr15:86004091 C/T cg19183879 chr15:85880815 NA -0.33 -8.03 -0.3 4.84e-15 Coronary artery disease; BRCA cis rs3806843 0.966 rs2337986 chr5:140160622 C/T cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.78 -0.36 3.67e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs9815354 0.812 rs17283243 chr3:41914792 C/T cg03022575 chr3:42003672 ULK4 0.69 9.49 0.35 4.43e-20 Pulse pressure;Diastolic blood pressure; BRCA cis rs1878931 0.507 rs4429296 chr16:3408277 T/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.46 -8.06 -0.3 3.7e-15 Body mass index (adult); BRCA cis rs6121246 0.821 rs6121209 chr20:30311258 G/C cg13852791 chr20:30311386 BCL2L1 0.86 16.53 0.55 2.2e-51 Mean corpuscular hemoglobin; BRCA cis rs2625529 0.878 rs16956302 chr15:72136243 C/T cg16672083 chr15:72433130 SENP8 -0.83 -16.87 -0.56 4.44e-53 Red blood cell count; BRCA cis rs16976116 0.951 rs3809540 chr15:55489412 A/C cg11288833 chr15:55489084 RSL24D1 0.48 11.04 0.4 4.83e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1129187 0.967 rs11752813 chr6:42928017 C/G cg27588902 chr6:42928151 GNMT -0.31 -10.24 -0.38 7.05e-23 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs11997175 0.583 rs34540455 chr8:33799300 C/T ch.8.33884649F chr8:33765107 NA 0.36 8.48 0.32 1.62e-16 Body mass index; BRCA cis rs1451375 0.959 rs1451373 chr7:50622606 A/G cg18232548 chr7:50535776 DDC 0.43 9.97 0.37 7.51e-22 Malaria; BRCA cis rs6964587 1.000 rs7805077 chr7:91644553 A/G cg01689657 chr7:91764605 CYP51A1 0.21 7.82 0.3 2.26e-14 Breast cancer; BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg07262247 chr5:131593730 PDLIM4 0.36 8.58 0.32 7.25e-17 Acylcarnitine levels; BRCA cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg08219700 chr8:58056026 NA 0.45 8.29 0.31 6.75e-16 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs2637266 0.967 rs6480826 chr10:78356154 A/G cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.38e-14 Pulmonary function; BRCA cis rs10080237 0.564 rs2490224 chr6:80809833 G/A cg08355045 chr6:80787529 NA 0.42 11.04 0.4 4.88e-26 Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals; BRCA cis rs7760949 0.889 rs9475816 chr6:13935425 T/C cg27413430 chr6:13925136 RNF182 0.46 9.24 0.34 3.66e-19 Mean corpuscular hemoglobin concentration; BRCA trans rs6598955 0.671 rs6681452 chr1:26621101 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.79 -0.53 1.13e-47 Obesity-related traits; BRCA cis rs2204008 0.743 rs2132212 chr12:38039405 G/A cg26384229 chr12:38710491 ALG10B 0.57 13.42 0.47 2.45e-36 Bladder cancer; BRCA cis rs713587 0.521 rs6545766 chr2:25077856 C/T cg04586622 chr2:25135609 ADCY3 0.4 10.1 0.37 2.28e-22 Body mass index in non-asthmatics; BRCA cis rs7618915 0.547 rs11130313 chr3:52676190 A/C cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.45e-16 Bipolar disorder; BRCA cis rs1712517 0.873 rs1712510 chr10:105009086 A/G cg05636881 chr10:105038444 INA -0.39 -9.04 -0.34 1.83e-18 Migraine; BRCA cis rs11098499 0.954 rs12508504 chr4:120410607 A/C cg09307838 chr4:120376055 NA 0.74 15.87 0.53 4.38e-48 Corneal astigmatism; BRCA trans rs10506458 0.834 rs55966529 chr12:63384114 A/C cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.19 -19.2 -0.6 3.13e-65 Hemostatic factors and hematological phenotypes; BRCA cis rs2762353 0.574 rs34067542 chr6:25728210 T/A cg03264133 chr6:25882463 NA 0.73 16.65 0.55 5.4e-52 Blood metabolite levels; BRCA cis rs9309711 0.922 rs13399524 chr2:3480206 C/G cg10845886 chr2:3471009 TTC15 -0.73 -16.03 -0.54 7.33e-49 Neurofibrillary tangles; BRCA cis rs6138458 0.961 rs227625 chr20:24911618 T/C cg06937882 chr20:24974362 C20orf3 -0.44 -8.36 -0.31 3.95e-16 Blood protein levels; BRCA cis rs7659604 0.539 rs11731917 chr4:122783233 G/A cg19748678 chr4:122722346 EXOSC9 0.74 15.94 0.53 2.18e-48 Type 2 diabetes; BRCA cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7089973 0.604 rs1924034 chr10:116578539 C/T cg23260525 chr10:116636907 FAM160B1 0.3 7.81 0.3 2.42e-14 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs7666738 0.791 rs10856933 chr4:98958542 C/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 1.000 rs6693336 chr1:46354595 C/T cg03146154 chr1:46216737 IPP 0.45 9.95 0.37 8.9e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs561341 0.769 rs9899093 chr17:30191954 C/G cg27661571 chr11:113659931 NA -0.57 -7.84 -0.3 1.84e-14 Hip circumference adjusted for BMI; BRCA cis rs9649213 0.613 rs6961129 chr7:97975542 T/G cg01877450 chr7:97915802 BRI3 -0.39 -8.8 -0.33 1.3e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs3008870 1.000 rs7511948 chr1:67430427 A/G cg08660285 chr1:67390436 MIER1;WDR78 1.0 22.78 0.67 1.56e-84 Lymphocyte percentage of white cells; BRCA cis rs12142240 0.667 rs66990604 chr1:46822073 G/A cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs2839186 0.770 rs2839984 chr21:47671690 A/G cg13012494 chr21:47604986 C21orf56 0.45 9.41 0.35 8.83e-20 Testicular germ cell tumor; BRCA cis rs7927771 0.832 rs11605672 chr11:47413733 A/G cg18512352 chr11:47633146 NA -0.32 -7.97 -0.3 7.41e-15 Subjective well-being; BRCA cis rs7666738 0.830 rs13108871 chr4:98803872 T/C cg05340658 chr4:99064831 C4orf37 0.62 14.78 0.5 9.85e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs112158604 1 rs112158604 chr1:150696792 TCTTCTGCAG/T cg18016565 chr1:150552671 MCL1 -0.41 -9.45 -0.35 6.49e-20 Lymphocyte counts; BRCA cis rs56399783 0.901 rs55767077 chr7:2774608 C/T cg19731401 chr7:2775893 GNA12 0.52 8.28 0.31 7.04e-16 Childhood ear infection; BRCA cis rs11625487 0.957 rs10145540 chr14:77957354 C/T cg20045696 chr14:77926864 AHSA1 -0.42 -7.94 -0.3 8.8e-15 Neutrophil percentage of white cells;Sum neutrophil eosinophil counts;Neutrophil count; BRCA cis rs9309473 0.500 rs11688718 chr2:73760939 C/T cg20560298 chr2:73613845 ALMS1 -0.42 -11.36 -0.41 2.29e-27 Metabolite levels; BRCA cis rs586533 0.881 rs1790265 chr11:99511987 A/G cg22878054 chr11:99397252 CNTN5 0.31 7.84 0.3 1.85e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs11758351 1.000 rs11754744 chr6:26202605 G/A cg01420254 chr6:26195488 NA 0.59 9.01 0.34 2.36e-18 Gout;Renal underexcretion gout; BRCA cis rs2576037 0.583 rs2576050 chr18:44558912 T/C cg19077165 chr18:44547161 KATNAL2 0.64 14.56 0.5 1.17e-41 Personality dimensions; BRCA cis rs2075371 1.000 rs2075371 chr7:133984127 A/G cg02659138 chr7:134003124 SLC35B4 0.34 10.72 0.39 9.33e-25 Mean platelet volume; BRCA cis rs2594989 1.000 rs346082 chr3:11329216 C/G cg01796438 chr3:11312864 ATG7 -0.55 -8.27 -0.31 7.57e-16 Circulating chemerin levels; BRCA cis rs2880765 0.743 rs6497194 chr15:86014116 C/T cg10818794 chr15:86012489 AKAP13 -0.3 -8.3 -0.31 6.38e-16 Coronary artery disease; BRCA cis rs6867032 0.527 rs13190594 chr5:2012474 T/C cg26168224 chr5:2018326 NA 0.46 12.47 0.44 4.23e-32 Gut microbiome composition (winter); BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg05279229 chr7:1896384 MAD1L1 -0.4 -8.05 -0.3 4e-15 Bipolar disorder and schizophrenia; BRCA cis rs12142240 0.698 rs17361936 chr1:46862893 C/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.57 -0.35 2.32e-20 Menopause (age at onset); BRCA cis rs6545883 0.965 rs9989775 chr2:61761774 A/G cg15711740 chr2:61764176 XPO1 -0.55 -14.14 -0.49 1.11e-39 Tuberculosis; BRCA cis rs7666738 0.822 rs13110418 chr4:99046963 G/A cg17366294 chr4:99064904 C4orf37 0.46 10.9 0.4 1.66e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs559928 0.556 rs11607903 chr11:63932140 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.87 11.56 0.42 3.32e-28 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs8058578 0.832 rs35969813 chr16:30714417 T/C cg02466173 chr16:30829666 NA -0.5 -10.24 -0.38 7.18e-23 Multiple myeloma; BRCA cis rs7811142 0.830 rs78256546 chr7:99952970 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.76 12.41 0.44 8.15e-32 Platelet count; BRCA cis rs870825 0.616 rs9631782 chr4:185626379 A/G cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs3862260 0.509 rs10754416 chr1:120163531 A/G cg16322792 chr1:120165303 ZNF697 0.57 15.34 0.52 1.82e-45 Systemic lupus erythematosus; BRCA cis rs7829975 0.688 rs7826660 chr8:8379107 C/A cg06636001 chr8:8085503 FLJ10661 0.68 15.42 0.52 7.42e-46 Mood instability; BRCA cis rs4665809 1.000 rs10170359 chr2:26272219 G/T cg25036284 chr2:26402008 FAM59B -0.68 -11.02 -0.4 5.67e-26 Gut microbiome composition (summer); BRCA cis rs36051895 0.695 rs1327494 chr9:4999303 A/G cg02405213 chr9:5042618 JAK2 -0.51 -9.06 -0.34 1.58e-18 Pediatric autoimmune diseases; BRCA cis rs7618915 1.000 rs59565798 chr3:52307169 G/A cg18404041 chr3:52824283 ITIH1 -0.39 -10.28 -0.38 4.95e-23 Bipolar disorder; BRCA cis rs2991971 1.000 rs667626 chr1:46020551 T/C cg24296786 chr1:45957014 TESK2 0.6 14.64 0.5 4.77e-42 High light scatter reticulocyte count; BRCA trans rs587242 0.910 rs6671342 chr1:97000957 T/G cg10631902 chr5:14652156 NA 0.37 8.9 0.33 5.81e-18 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs2070488 0.775 rs1073505 chr3:38566722 T/C cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.73 -0.53 2.29e-47 Electrocardiographic conduction measures; BRCA trans rs61931739 0.534 rs1852222 chr12:34008665 C/A cg26384229 chr12:38710491 ALG10B 0.51 10.82 0.39 3.73e-25 Morning vs. evening chronotype; BRCA cis rs7827545 1.000 rs4909911 chr8:135565255 G/A cg17885191 chr8:135476712 NA 0.47 9.19 0.34 5.3e-19 Hypertension (SNP x SNP interaction); BRCA cis rs651907 0.557 rs62284198 chr3:101474699 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.57 15.63 0.53 6.83e-47 Colorectal cancer; BRCA cis rs908922 0.676 rs7545336 chr1:152527863 A/G cg20991723 chr1:152506922 NA 0.37 8.29 0.31 6.78e-16 Hair morphology; BRCA cis rs7666738 0.761 rs28758886 chr4:99059704 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.19e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs4237845 0.537 rs7312623 chr12:58262523 G/T cg00677455 chr12:58241039 CTDSP2 0.69 16.01 0.54 8.97e-49 Intelligence (multi-trait analysis); BRCA trans rs17685 0.712 rs60721456 chr7:75743820 T/A cg19862616 chr7:65841803 NCRNA00174 0.79 25.02 0.7 8.03e-97 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs96067 0.805 rs12033825 chr1:36600311 C/T cg24686825 chr1:36642396 MAP7D1 -0.48 -8.84 -0.33 9.11e-18 Corneal structure; BRCA cis rs6088590 0.561 rs6088527 chr20:33155841 C/T cg08999081 chr20:33150536 PIGU 0.5 14.12 0.49 1.29e-39 Coronary artery disease; BRCA trans rs78049276 0.562 rs55965782 chr4:148378442 T/C cg13149281 chr14:23389818 RBM23;PRMT5 -0.45 -8.35 -0.31 4.14e-16 Pulse pressure; BRCA cis rs4363385 0.720 rs1338178 chr1:152981550 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.1 -0.34 1.11e-18 Inflammatory skin disease; BRCA cis rs1971762 0.563 rs10219725 chr12:54080865 T/G cg23533419 chr12:54090519 NA -0.34 -8.48 -0.32 1.57e-16 Height; BRCA cis rs6952808 1.000 rs4721121 chr7:1892565 A/G cg02951883 chr7:2050386 MAD1L1 -0.38 -8.42 -0.32 2.45e-16 Bipolar disorder and schizophrenia; BRCA cis rs425277 1.000 rs262641 chr1:2104981 C/T cg24578937 chr1:2090814 PRKCZ -0.49 -15.96 -0.53 1.67e-48 Height; BRCA cis rs10504229 0.906 rs7003276 chr8:58173089 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.68 -0.36 9.36e-21 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1414351 chr6:8476634 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs2404602 0.631 rs9646213 chr15:76807672 G/C cg23625390 chr15:77176239 SCAPER 0.4 9.31 0.35 1.98e-19 Blood metabolite levels; BRCA cis rs2075371 0.871 rs418135 chr7:133949898 A/G cg20476274 chr7:133979776 SLC35B4 0.59 15.64 0.53 6.64e-47 Mean platelet volume; BRCA cis rs4389656 0.826 rs395939 chr5:6734245 T/C cg10857441 chr5:6722123 POLS -0.25 -7.86 -0.3 1.66e-14 Coronary artery disease; BRCA cis rs897080 0.515 rs1067358 chr2:44662183 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.5 8.96 0.33 3.66e-18 Height; BRCA cis rs769267 0.929 rs2965180 chr19:19491973 T/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -9.11 -0.34 1.07e-18 Tonsillectomy; BRCA cis rs6952808 1.000 rs6978048 chr7:1886872 T/G cg04267008 chr7:1944627 MAD1L1 -0.65 -13.77 -0.48 5.9e-38 Bipolar disorder and schizophrenia; BRCA cis rs7552404 0.924 rs2153126 chr1:76199345 C/G cg22875332 chr1:76189707 ACADM 0.81 19.69 0.61 8.33e-68 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs28374715 0.578 rs13313520 chr15:41629127 T/G cg18705301 chr15:41695430 NDUFAF1 -1.06 -25.81 -0.71 3.64e-101 Ulcerative colitis; BRCA cis rs35306767 0.903 rs11253462 chr10:889323 T/G cg20503657 chr10:835505 NA 0.93 16.59 0.55 1.17e-51 Eosinophil percentage of granulocytes; BRCA cis rs7011049 1.000 rs72643590 chr8:53849595 A/G cg26025543 chr8:53854495 NA 0.55 9.57 0.35 2.31e-20 Systolic blood pressure; BRCA cis rs651907 0.557 rs11917569 chr3:101355063 G/C cg03334568 chr3:101395165 ZBTB11;LOC100009676 -0.41 -7.83 -0.3 2.07e-14 Colorectal cancer; BRCA trans rs11098499 0.708 rs10005237 chr4:120237897 T/C cg25214090 chr10:38739885 LOC399744 0.44 10.29 0.38 4.34e-23 Corneal astigmatism; BRCA cis rs12142240 0.698 rs932816 chr1:46859749 G/A cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA cis rs875971 0.545 rs4441996 chr7:65588220 T/C cg11764359 chr7:65958608 NA -0.67 -12.33 -0.44 1.73e-31 Aortic root size; BRCA cis rs7107356 1 rs7107356 chr11:47676170 A/G cg03711944 chr11:47377212 SPI1 -0.31 -8.09 -0.3 3.11e-15 Neuroticism;Neuroticism (multi-trait analysis); BRCA cis rs7953508 0.506 rs2053196 chr12:93962959 T/C cg18151635 chr12:93972918 NA -0.47 -9.5 -0.35 4.12e-20 Pubertal anthropometrics; BRCA cis rs9467773 1.000 rs9295695 chr6:26528250 C/T cg09904177 chr6:26538194 HMGN4 -0.56 -18.28 -0.59 2.19e-60 Intelligence (multi-trait analysis); BRCA cis rs7949030 0.626 rs72927213 chr11:62351198 G/C cg22862634 chr11:62369728 EML3;MTA2 0.57 13.66 0.48 1.96e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11051970 0.659 rs950082 chr12:32588414 G/T cg02745156 chr12:32552066 NA 0.27 8.21 0.31 1.27e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs4689592 0.523 rs6446565 chr4:7074027 A/G cg19539972 chr4:7069911 GRPEL1 0.7 16.92 0.56 2.33e-53 Monocyte percentage of white cells; BRCA cis rs4906332 0.834 rs12882130 chr14:103878774 C/G cg04998671 chr14:104000505 TRMT61A -0.37 -8.1 -0.31 2.77e-15 Coronary artery disease; BRCA cis rs13191362 0.935 rs34934114 chr6:163082480 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.55 8.33 0.31 4.93e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs736408 0.500 rs2878762 chr3:52919002 T/C cg18404041 chr3:52824283 ITIH1 -0.31 -8.18 -0.31 1.48e-15 Bipolar disorder; BRCA cis rs8180040 0.726 rs7625070 chr3:47095518 A/G cg27129171 chr3:47204927 SETD2 0.77 19.95 0.62 3.42e-69 Colorectal cancer; BRCA cis rs9814567 1.000 rs55913793 chr3:134285968 G/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.91 -0.33 5.1e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs11711311 0.955 rs1048892 chr3:113464859 A/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.45 -9.75 -0.36 5.06e-21 IgG glycosylation; BRCA cis rs35110281 0.659 rs73367822 chr21:45024252 C/T cg21573476 chr21:45109991 RRP1B -0.35 -9.19 -0.34 5.47e-19 Mean corpuscular volume; BRCA cis rs12477438 0.765 rs4851183 chr2:99629149 G/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.73 -0.42 6.2e-29 Chronic sinus infection; BRCA cis rs12142240 0.698 rs17357683 chr1:46815378 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs514406 0.929 rs557847 chr1:53333116 A/G cg27535305 chr1:53392650 SCP2 -0.37 -9.11 -0.34 1.05e-18 Monocyte count; BRCA cis rs2115630 1.000 rs6496441 chr15:85363348 A/G cg12863693 chr15:85201151 NMB -0.36 -8.66 -0.32 3.71e-17 P wave terminal force; BRCA cis rs61931739 0.500 rs12829125 chr12:34314789 A/G cg06521331 chr12:34319734 NA -0.65 -11.92 -0.43 1.03e-29 Morning vs. evening chronotype; BRCA cis rs1801251 1.000 rs6745879 chr2:233590007 A/G cg25237894 chr2:233734115 C2orf82 0.4 11.5 0.41 6.01e-28 Coronary artery disease; BRCA cis rs919433 0.929 rs4850788 chr2:198182940 G/A cg10820045 chr2:198174542 NA -0.45 -10.47 -0.38 8.77e-24 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs3741404 0.895 rs1860368 chr11:63994692 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 -0.8 -18.59 -0.59 5.42e-62 Platelet count; BRCA cis rs709400 0.633 rs1951391 chr14:103898313 T/C cg26031613 chr14:104095156 KLC1 0.72 15.33 0.52 2.01e-45 Body mass index; BRCA cis rs7352944 0.686 rs6125877 chr20:48658312 G/T cg17835207 chr20:48524531 SPATA2 0.4 8.93 0.33 4.55e-18 Psoriasis; BRCA cis rs651907 0.557 rs13081846 chr3:101383321 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.81 0.51 7.41e-43 Colorectal cancer; BRCA cis rs1552244 1.000 rs111392584 chr3:10075991 A/G cg13047869 chr3:10149882 C3orf24 0.58 12.2 0.43 6.43e-31 Alzheimer's disease; BRCA cis rs1865760 1.000 rs6910138 chr6:25904352 C/G cg16482183 chr6:26056742 HIST1H1C 0.54 11.18 0.4 1.23e-26 Height; BRCA trans rs61931739 0.500 rs10844789 chr12:34202279 C/G cg26384229 chr12:38710491 ALG10B 0.67 14.29 0.49 2.1e-40 Morning vs. evening chronotype; BRCA cis rs1008375 0.966 rs6839660 chr4:17667987 C/T cg04450456 chr4:17643702 FAM184B 0.38 11.4 0.41 1.63e-27 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12477438 0.798 rs12477754 chr2:99628073 G/A cg08885076 chr2:99613938 TSGA10 -0.59 -13.08 -0.46 8e-35 Chronic sinus infection; BRCA cis rs2842992 1.000 rs2842992 chr6:160071159 G/A cg11366901 chr6:160182831 ACAT2 0.69 13.05 0.46 1.14e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs870825 0.616 rs1401362 chr4:185643775 G/A cg04058563 chr4:185651563 MLF1IP 0.77 17.2 0.56 9.11e-55 Blood protein levels; BRCA cis rs11059919 1 rs11059919 chr12:129289190 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.27 -0.52 4.31e-45 Systemic lupus erythematosus; BRCA trans rs7615952 0.605 rs11708269 chr3:125332150 C/T cg07211511 chr3:129823064 LOC729375 -0.65 -7.82 -0.3 2.19e-14 Blood pressure (smoking interaction); BRCA cis rs11123170 0.543 rs35222158 chr2:113986629 C/T cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.66 10.65 0.39 1.71e-24 Renal function-related traits (BUN); BRCA cis rs35123781 0.696 rs4912756 chr5:139070780 A/T cg10513866 chr5:139070639 NA 0.44 9.76 0.36 4.65e-21 Schizophrenia; BRCA cis rs2011503 1.000 rs11669730 chr19:19648713 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 9.19e-19 Bipolar disorder; BRCA cis rs2762353 0.935 rs2817188 chr6:25807603 A/G cg03264133 chr6:25882463 NA -0.48 -10.78 -0.39 5.01e-25 Blood metabolite levels; BRCA cis rs4665809 1.000 rs4665817 chr2:26305167 G/A cg08470875 chr2:26401718 FAM59B -0.63 -9.41 -0.35 8.56e-20 Gut microbiome composition (summer); BRCA trans rs2204008 0.744 rs1115514 chr12:38280140 C/T cg06521331 chr12:34319734 NA -0.51 -9.81 -0.36 2.93e-21 Bladder cancer; BRCA cis rs7552404 1.000 rs7524467 chr1:76194054 C/G cg03433033 chr1:76189801 ACADM 0.76 16.93 0.56 2.05e-53 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7772486 0.875 rs1331639 chr6:146431869 A/G cg23711669 chr6:146136114 FBXO30 -0.71 -16.44 -0.55 6.34e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs7824557 0.614 rs2736277 chr8:11218893 C/T cg21775007 chr8:11205619 TDH -0.57 -12.88 -0.45 6.51e-34 Retinal vascular caliber; BRCA trans rs1005277 0.540 rs2145487 chr10:38010077 A/G cg17830980 chr10:43048298 ZNF37B -0.41 -9.62 -0.36 1.51e-20 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs34916200 chr4:98851593 C/T cg17366294 chr4:99064904 C4orf37 0.42 9.92 0.37 1.13e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg11189052 chr15:85197271 WDR73 -0.38 -9.06 -0.34 1.61e-18 P wave terminal force; BRCA cis rs6570726 0.905 rs452770 chr6:145847162 T/C cg23711669 chr6:146136114 FBXO30 0.65 15.23 0.52 6.75e-45 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 0.662 rs7372545 chr3:38507570 T/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 12.61 0.45 9.85e-33 Electrocardiographic conduction measures; BRCA cis rs7246657 1.000 rs6508710 chr19:37749886 A/G cg18154014 chr19:37997991 ZNF793 0.48 9.11 0.34 1.05e-18 Coronary artery calcification; BRCA cis rs1865760 0.865 rs1436306 chr6:25948421 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 9.31 0.35 1.97e-19 Height; BRCA cis rs7760949 0.889 rs9475795 chr6:13931270 A/C cg27413430 chr6:13925136 RNF182 0.46 9.34 0.35 1.51e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs10791323 0.628 rs1893850 chr11:133705356 T/C cg06766960 chr11:133703094 NA -0.61 -12.92 -0.46 4.14e-34 Childhood ear infection; BRCA cis rs13191362 1.000 rs67042566 chr6:163006541 A/T cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.62 0.45 8.94e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.618 rs6858383 chr4:120296772 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 8.11 0.31 2.56e-15 Corneal astigmatism; BRCA cis rs936229 0.813 rs1350193 chr15:75084281 G/C cg10253484 chr15:75165896 SCAMP2 -0.53 -10.12 -0.37 2.04e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA trans rs61931739 0.500 rs7979769 chr12:34509522 C/T cg26384229 chr12:38710491 ALG10B 0.75 16.58 0.55 1.31e-51 Morning vs. evening chronotype; BRCA cis rs1878931 0.535 rs55732163 chr16:3411518 A/C cg26668626 chr16:3451006 ZNF174;ZNF434 -0.53 -9.02 -0.34 2.11e-18 Body mass index (adult); BRCA cis rs7647973 1.000 rs1464569 chr3:49460350 A/G cg07636037 chr3:49044803 WDR6 0.77 16.73 0.55 2.36e-52 Menarche (age at onset); BRCA cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.37e-37 Developmental language disorder (linguistic errors); BRCA cis rs6951245 0.706 rs28483034 chr7:1170171 C/A cg03188948 chr7:1209495 NA 0.9 14.22 0.49 4.57e-40 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10503871 0.657 rs13248936 chr8:30316162 C/T cg26383811 chr8:30366931 RBPMS -0.3 -8.18 -0.31 1.52e-15 Metabolite levels (X-11787); BRCA cis rs6866344 0.697 rs11742808 chr5:178131658 G/A cg10224037 chr5:178157518 ZNF354A 0.76 16.28 0.54 4.27e-50 Neutrophil percentage of white cells; BRCA cis rs60843830 0.633 rs1078763 chr2:113763 A/G cg00108164 chr2:264199 ACP1;SH3YL1 -0.44 -8.15 -0.31 1.9e-15 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9914988 0.725 rs66531973 chr17:27125993 G/T cg20469991 chr17:27169893 C17orf63 -0.44 -8.77 -0.33 1.57e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs6951245 1.000 rs2363286 chr7:1091625 A/G cg08132940 chr7:1081526 C7orf50 -0.53 -8.21 -0.31 1.24e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs7258465 0.965 rs271628 chr19:18624333 A/G cg01065977 chr19:18549689 ISYNA1 -0.29 -8.48 -0.32 1.51e-16 Breast cancer; BRCA cis rs1801251 1.000 rs7587309 chr2:233705702 G/T cg08000102 chr2:233561755 GIGYF2 -0.62 -13.39 -0.47 3.37e-36 Coronary artery disease; BRCA cis rs5750830 0.594 rs1010170 chr22:39778327 C/T cg11247378 chr22:39784982 NA 0.62 13.69 0.48 1.34e-37 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.846 rs6768818 chr3:160951648 A/G cg04691961 chr3:161091175 C3orf57 -0.42 -10.17 -0.37 1.23e-22 Morning vs. evening chronotype; BRCA trans rs11098499 0.564 rs11098507 chr4:120288286 G/A cg25214090 chr10:38739885 LOC399744 0.5 11.47 0.41 8.07e-28 Corneal astigmatism; BRCA cis rs8005677 1.000 rs4982710 chr14:23398902 C/T cg01529538 chr14:23388837 RBM23 0.41 11.12 0.4 2.25e-26 Cognitive ability (multi-trait analysis); BRCA cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg26384229 chr12:38710491 ALG10B 0.76 17.17 0.56 1.31e-54 Bladder cancer; BRCA cis rs17376456 1.000 rs17323433 chr5:93551028 G/A cg21475434 chr5:93447410 FAM172A 0.66 8.49 0.32 1.43e-16 Diabetic retinopathy; BRCA cis rs2239547 0.522 rs6770957 chr3:52995416 T/C cg18404041 chr3:52824283 ITIH1 -0.3 -7.82 -0.3 2.26e-14 Schizophrenia; BRCA trans rs11098499 0.863 rs7699064 chr4:120428309 A/G cg19731845 chr4:166199412 KLHL2;GK3P -0.35 -7.92 -0.3 1.07e-14 Corneal astigmatism; BRCA cis rs9649213 0.593 rs35535338 chr7:97962319 C/T cg21770322 chr7:97807741 LMTK2 0.45 11.96 0.43 6.82e-30 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.522 rs4718286 chr7:65292764 A/G cg11764359 chr7:65958608 NA 0.62 13.55 0.47 6.08e-37 Aortic root size; BRCA cis rs11585357 0.947 rs6684387 chr1:17611519 T/C cg19159961 chr1:17633534 PADI4 -0.5 -8.97 -0.33 3.35e-18 Hair shape; BRCA cis rs1003719 0.715 rs1981433 chr21:38542223 T/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.36 -0.49 1e-40 Eye color traits; BRCA cis rs1949733 0.701 rs871768 chr4:8454938 G/A cg11789530 chr4:8429930 ACOX3 0.59 14.72 0.5 1.85e-42 Response to antineoplastic agents; BRCA cis rs6952808 0.608 rs58120505 chr7:2029867 T/C cg05863683 chr7:1912471 MAD1L1 0.36 8.27 0.31 7.51e-16 Bipolar disorder and schizophrenia; BRCA cis rs2072499 0.966 rs2853641 chr1:156181770 A/G cg25208724 chr1:156163844 SLC25A44 1.0 32.71 0.79 1.26e-138 Testicular germ cell tumor; BRCA cis rs10504229 0.679 rs56040464 chr8:58131603 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.88 -0.33 6.93e-18 Developmental language disorder (linguistic errors); BRCA cis rs950169 0.580 rs11634322 chr15:85172209 C/T cg17507749 chr15:85114479 UBE2QP1 0.57 10.79 0.39 4.64e-25 Schizophrenia; BRCA cis rs3849570 0.961 rs3821548 chr3:81758728 C/G cg07356753 chr3:81810745 GBE1 -0.45 -10.96 -0.4 1.01e-25 Waist circumference;Body mass index; BRCA cis rs11690935 0.632 rs62183783 chr2:172865775 A/G cg13550731 chr2:172543902 DYNC1I2 0.51 12.6 0.45 1.2e-32 Schizophrenia; BRCA cis rs12477438 0.520 rs11123766 chr2:99780915 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 23.2 0.68 7.62e-87 Chronic sinus infection; BRCA cis rs9443645 0.527 rs9359360 chr6:79702796 C/T cg18132916 chr6:79620363 NA -0.4 -8.11 -0.31 2.65e-15 Intelligence (multi-trait analysis); BRCA cis rs769267 0.965 rs1469712 chr19:19528821 C/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.88 0.43 1.57e-29 Tonsillectomy; BRCA cis rs6728642 1.000 rs80303184 chr2:98024633 G/A cg26665480 chr2:98280029 ACTR1B -0.68 -7.9 -0.3 1.21e-14 Bipolar disorder lithium response (continuous) or schizophrenia; BRCA cis rs738322 0.836 rs4821741 chr22:38514745 A/G cg20207973 chr22:38506712 BAIAP2L2 0.39 9.84 0.36 2.19e-21 Cutaneous nevi; BRCA cis rs1733410 0.504 rs11181874 chr12:37912890 C/A cg13010199 chr12:38710504 ALG10B -0.41 -8.75 -0.33 1.94e-17 Morning vs. evening chronotype; BRCA cis rs595018 0.505 rs11230501 chr11:60598075 G/A cg07268726 chr11:60701918 TMEM132A -0.48 -7.99 -0.3 6.12e-15 Wegener's granulomatosis; BRCA cis rs4665809 1.000 rs11126364 chr2:26314515 A/G cg25036284 chr2:26402008 FAM59B -0.64 -10.59 -0.39 3.03e-24 Gut microbiome composition (summer); BRCA cis rs4727027 0.866 rs12666477 chr7:148812322 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.37 8.37 0.31 3.58e-16 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1633360 1 rs1633360 chr12:58108052 C/T cg18357645 chr12:58087776 OS9 0.4 11.63 0.42 1.74e-28 Rheumatoid arthritis; BRCA cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs11718455 0.960 rs34179760 chr3:44002303 A/G cg08738300 chr3:44038990 NA 0.44 8.55 0.32 9.12e-17 Coronary artery disease; BRCA cis rs16910800 0.731 rs59845980 chr11:23191511 T/G cg20040320 chr11:23191996 NA -0.59 -10.23 -0.38 7.61e-23 Cancer; BRCA cis rs35110281 0.807 rs9984002 chr21:45061501 T/C cg04455712 chr21:45112962 RRP1B 0.38 9.76 0.36 4.61e-21 Mean corpuscular volume; BRCA cis rs2836950 0.545 rs1888489 chr21:40533164 T/C cg22974920 chr21:40686053 BRWD1 -0.36 -8.05 -0.3 4.14e-15 Menarche (age at onset); BRCA cis rs2282802 0.685 rs10077671 chr5:139689505 C/T cg26211634 chr5:139558579 C5orf32 0.33 8.0 0.3 5.84e-15 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.511 rs2591952 chr5:56120769 T/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.6 -0.39 2.71e-24 Initial pursuit acceleration; BRCA cis rs11098499 0.863 rs3822190 chr4:120428098 G/A cg09307838 chr4:120376055 NA 0.69 13.72 0.48 1.03e-37 Corneal astigmatism; BRCA cis rs11030122 0.661 rs4910877 chr11:4062153 A/G cg18678763 chr11:4115507 RRM1 -0.34 -8.19 -0.31 1.45e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs2762353 0.639 rs566530 chr6:25878361 T/C cg03264133 chr6:25882463 NA -0.48 -11.1 -0.4 2.77e-26 Blood metabolite levels; BRCA cis rs2839186 0.814 rs2839167 chr21:47661587 A/G cg13012494 chr21:47604986 C21orf56 0.43 8.94 0.33 3.99e-18 Testicular germ cell tumor; BRCA cis rs8141529 0.748 rs5752826 chr22:29269808 A/G cg02153584 chr22:29168773 CCDC117 0.54 11.19 0.4 1.09e-26 Lymphocyte counts; BRCA cis rs2108225 0.714 rs10953548 chr7:107436232 G/A cg18560240 chr7:107437656 SLC26A3 -0.57 -12.04 -0.43 2.98e-30 Ulcerative colitis; BRCA trans rs17685 0.753 rs1637037 chr7:75692927 C/T cg19862616 chr7:65841803 NCRNA00174 0.85 28.47 0.75 9.74e-116 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs921968 0.541 rs733925 chr2:219302466 G/A cg02176678 chr2:219576539 TTLL4 -0.44 -11.58 -0.42 2.7e-28 Mean corpuscular hemoglobin concentration; BRCA cis rs6952808 0.964 rs10950400 chr7:1882470 C/T cg21782813 chr7:2030301 MAD1L1 0.39 10.18 0.37 1.2e-22 Bipolar disorder and schizophrenia; BRCA cis rs12618769 0.625 rs3769736 chr2:99089119 C/T cg10123293 chr2:99228465 UNC50 0.42 8.24 0.31 1.01e-15 Bipolar disorder; BRCA cis rs9381107 0.932 rs9369200 chr6:9453471 C/T cg14735645 chr6:9486422 NA -0.45 -7.95 -0.3 8.56e-15 Nonsyndromic cleft lip with cleft palate; BRCA cis rs3858526 0.920 rs10742832 chr11:5926020 C/G cg02574844 chr11:5959923 NA -0.42 -8.16 -0.31 1.79e-15 DNA methylation (variation); BRCA cis rs896854 0.654 rs4735339 chr8:95974373 C/T cg13393036 chr8:95962371 TP53INP1 -0.3 -8.06 -0.3 3.7e-15 Type 2 diabetes; BRCA cis rs72781680 0.898 rs56413706 chr2:24086961 G/A cg20701182 chr2:24300061 SF3B14 0.66 9.71 0.36 6.96e-21 Lymphocyte counts; BRCA cis rs17401966 0.838 rs12141246 chr1:10327407 A/T cg03954927 chr1:10346856 KIF1B 0.43 13.57 0.47 5.02e-37 Hepatocellular carcinoma; BRCA cis rs72766638 0.848 rs11789898 chr9:136925663 A/C cg13789015 chr9:136890014 NCRNA00094 -0.56 -9.04 -0.34 1.82e-18 Mosquito bite size; BRCA cis rs3749237 1.000 rs11717256 chr3:49868520 C/T cg07636037 chr3:49044803 WDR6 0.4 8.16 0.31 1.74e-15 Resting heart rate; BRCA cis rs7100689 0.646 rs10400045 chr10:82077032 A/G cg00277334 chr10:82204260 NA -0.43 -8.47 -0.32 1.74e-16 Post bronchodilator FEV1; BRCA cis rs7737355 0.947 rs31258 chr5:130824536 G/A cg06307176 chr5:131281290 NA 0.52 10.4 0.38 1.71e-23 Life satisfaction; BRCA cis rs7811142 1.000 rs4472444 chr7:100070758 T/C cg00814883 chr7:100076585 TSC22D4 -0.52 -11.99 -0.43 4.88e-30 Platelet count; BRCA cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.56 14.28 0.49 2.48e-40 Electrocardiographic conduction measures; BRCA cis rs2555155 1.000 rs11604149 chr11:6519642 G/A cg18103150 chr11:6518907 DNHD1 -0.34 -7.91 -0.3 1.17e-14 DNA methylation (variation); BRCA cis rs479844 0.617 rs12146493 chr11:65547333 G/A cg08755490 chr11:65554678 OVOL1 0.46 8.8 0.33 1.31e-17 Allergic disease (asthma, hay fever or eczema);Atopic march;Atopic dermatitis; BRCA cis rs10089 1.000 rs1559263 chr5:127512873 A/C cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 12.89 0.45 5.95e-34 Ileal carcinoids; BRCA cis rs6496044 0.634 rs4843066 chr15:86062911 C/T cg10818794 chr15:86012489 AKAP13 -0.29 -8.01 -0.3 5.46e-15 Interstitial lung disease; BRCA cis rs1420338 0.933 rs10228731 chr7:34150782 G/T cg01275685 chr7:34179230 BMPER -0.46 -10.24 -0.38 6.69e-23 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg00166722 chr3:10149974 C3orf24 0.65 11.23 0.41 7.83e-27 Alzheimer's disease; BRCA cis rs9875589 0.509 rs6768383 chr3:14076952 G/A cg14375111 chr3:14165186 TMEM43;CHCHD4 0.34 8.98 0.33 2.93e-18 Ovarian reserve; BRCA cis rs13191362 1.000 rs13210412 chr6:163019478 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.15 0.31 1.9e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs4713118 0.955 rs9468200 chr6:27683063 T/A cg20933634 chr6:27740509 NA 0.44 8.47 0.32 1.63e-16 Parkinson's disease; BRCA cis rs72928364 1.000 rs79265689 chr3:100621684 C/A cg10123952 chr3:100791384 NA 0.54 8.07 0.3 3.62e-15 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs854572 1.000 rs854572 chr7:94954696 C/G cg21856205 chr7:94953877 PON1 -0.51 -12.48 -0.44 3.9e-32 Paraoxonase activity; BRCA cis rs10911363 0.573 rs2702181 chr1:183516985 T/A cg09173681 chr1:183549694 NCF2 0.6 11.94 0.43 8.21e-30 Systemic lupus erythematosus; BRCA cis rs4466137 0.953 rs974023 chr5:83014848 T/C cg15083037 chr5:83017644 HAPLN1 -0.54 -10.86 -0.39 2.45e-25 Prostate cancer; BRCA trans rs1005277 0.579 rs1780145 chr10:38537070 A/G cg23533926 chr12:111358616 MYL2 -0.43 -8.96 -0.33 3.42e-18 Extrinsic epigenetic age acceleration; BRCA cis rs11098499 0.954 rs10518331 chr4:120323595 C/T cg09307838 chr4:120376055 NA 0.75 16.19 0.54 1.12e-49 Corneal astigmatism; BRCA cis rs7100689 0.646 rs1538823 chr10:82088040 C/A cg00277334 chr10:82204260 NA -0.43 -8.48 -0.32 1.53e-16 Post bronchodilator FEV1; BRCA cis rs2836950 0.501 rs2836984 chr21:40700949 A/C cg17971929 chr21:40555470 PSMG1 -0.47 -10.43 -0.38 1.28e-23 Menarche (age at onset); BRCA cis rs344364 0.511 rs2982433 chr16:1954508 A/G cg09830162 chr16:1889614 FAHD1;C16orf73 -0.45 -8.44 -0.32 2.21e-16 Glomerular filtration rate in chronic kidney disease; BRCA cis rs780096 0.546 rs7563162 chr2:27631191 C/T cg21248554 chr2:27665150 KRTCAP3 -0.35 -8.75 -0.33 1.84e-17 Total body bone mineral density; BRCA cis rs3008870 0.536 rs2208576 chr1:67513401 C/G cg02640540 chr1:67518911 SLC35D1 -0.42 -8.96 -0.33 3.44e-18 Lymphocyte percentage of white cells; BRCA cis rs2836950 0.520 rs8133928 chr21:40689963 G/A cg06238570 chr21:40685208 BRWD1 -0.4 -8.18 -0.31 1.55e-15 Menarche (age at onset); BRCA cis rs66887589 0.967 rs3775842 chr4:120427732 G/A cg09307838 chr4:120376055 NA 0.45 9.38 0.35 1.1e-19 Diastolic blood pressure; BRCA cis rs7618915 0.547 rs12487591 chr3:52642936 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.68 0.36 9.37e-21 Bipolar disorder; BRCA cis rs701145 0.537 rs1713832 chr3:153835833 C/T cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.2e-14 Coronary artery disease; BRCA cis rs2153535 0.580 rs2327053 chr6:8443127 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.43 0.38 1.24e-23 Motion sickness; BRCA trans rs11088226 0.846 rs2154501 chr21:33926451 G/A cg09050820 chr6:167586206 TCP10L2 0.57 10.82 0.39 3.76e-25 Gastritis; BRCA cis rs4803468 1.000 rs10853751 chr19:41903220 G/A cg09537434 chr19:41945824 ATP5SL -0.98 -23.22 -0.68 6.18e-87 Height; BRCA cis rs1865760 0.929 rs2876693 chr6:25954434 C/G cg16482183 chr6:26056742 HIST1H1C 0.51 10.44 0.38 1.12e-23 Height; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg24642844 chr7:1081250 C7orf50 -0.58 -12.06 -0.43 2.43e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.02e-16 Developmental language disorder (linguistic errors); BRCA cis rs7973719 0.865 rs1057225 chr12:7363574 C/G cg07052231 chr12:7363540 PEX5 0.36 8.16 0.31 1.74e-15 IgG glycosylation; BRCA cis rs7131987 0.903 rs11050162 chr12:29420054 T/G cg09582351 chr12:29534625 ERGIC2 -0.48 -11.73 -0.42 6.3e-29 QT interval; BRCA cis rs4808199 0.842 rs11085259 chr19:19445856 C/T cg01262667 chr19:19385393 TM6SF2 0.39 7.86 0.3 1.62e-14 Nonalcoholic fatty liver disease; BRCA cis rs6435862 0.636 rs717548 chr2:215676905 G/A cg04530015 chr2:215796436 ABCA12 0.39 8.74 0.33 2.06e-17 Neuroblastoma (high-risk); BRCA cis rs78456975 0.527 rs7590743 chr2:1575048 A/G cg12573674 chr2:1569213 NA -0.58 -12.65 -0.45 6.98e-33 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7927592 0.956 rs11228251 chr11:68244558 G/T cg20283391 chr11:68216788 NA -0.39 -7.81 -0.3 2.38e-14 Total body bone mineral density; BRCA cis rs2645694 0.626 rs2645705 chr4:77830434 G/A cg03477792 chr4:77819574 ANKRD56 0.64 15.41 0.52 8.45e-46 Emphysema distribution in smoking; BRCA cis rs875971 0.706 rs1643374 chr7:65872682 T/A cg11764359 chr7:65958608 NA 0.61 13.16 0.46 3.58e-35 Aortic root size; BRCA cis rs12950390 0.853 rs59513807 chr17:45867925 G/A cg03474202 chr17:45855739 NA -0.46 -12.02 -0.43 3.9e-30 IgG glycosylation; BRCA cis rs7666738 0.830 rs6839277 chr4:99015563 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.81 0.39 3.9e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6495122 0.501 rs7163636 chr15:75346760 C/T cg13906792 chr15:75199810 C15orf17 -0.33 -7.82 -0.3 2.11e-14 Caffeine consumption;Diastolic blood pressure;Coffee consumption; BRCA cis rs73086581 1.000 rs6052218 chr20:3970212 A/G cg02187196 chr20:3869020 PANK2 0.51 9.22 0.34 4.42e-19 Response to antidepressants in depression; BRCA cis rs4595586 0.545 rs6580888 chr12:39369704 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.4 0.35 9.51e-20 Morning vs. evening chronotype; BRCA cis rs17270561 0.636 rs1185977 chr6:25829054 A/G cg16482183 chr6:26056742 HIST1H1C 0.42 9.08 0.34 1.39e-18 Iron status biomarkers; BRCA cis rs6570726 0.577 rs867056 chr6:145784805 A/C cg13319975 chr6:146136371 FBXO30 0.6 13.61 0.47 3.32e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs12142240 0.659 rs72677591 chr1:46818219 T/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs6963495 0.818 rs711430 chr7:105167969 A/G cg19920283 chr7:105172520 RINT1 0.65 12.98 0.46 2.34e-34 Bipolar disorder (body mass index interaction); BRCA cis rs2288912 0.807 rs7251501 chr19:45455706 C/T cg20090143 chr19:45452003 APOC2 0.27 8.04 0.3 4.44e-15 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs13108904 0.934 rs13115173 chr4:1316824 T/C cg00684032 chr4:1343700 KIAA1530 0.43 10.44 0.38 1.16e-23 Obesity-related traits; BRCA cis rs10504229 0.817 rs10504230 chr8:58197150 A/G cg22535103 chr8:58192502 C8orf71 0.58 10.52 0.38 5.36e-24 Developmental language disorder (linguistic errors); BRCA cis rs6138458 1.000 rs11905625 chr20:24977065 A/C cg26195577 chr20:24973756 C20orf3 1.03 28.97 0.75 1.65e-118 Blood protein levels; BRCA trans rs1997103 0.954 rs1997099 chr7:55405540 T/C cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.04e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4665809 0.590 rs10197494 chr2:26445550 A/G cg04944784 chr2:26401820 FAM59B -0.95 -16.17 -0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs265548 0.608 rs36690 chr19:17910483 C/T cg16744531 chr19:17905626 B3GNT3 0.55 11.91 0.43 1.11e-29 Tumor biomarkers; BRCA cis rs12893668 0.572 rs4906350 chr14:104111794 C/T cg01849466 chr14:104193079 ZFYVE21 -0.45 -10.24 -0.38 6.82e-23 Reticulocyte count; BRCA cis rs3806843 0.766 rs702397 chr5:140050265 A/G cg26395211 chr5:140044315 WDR55 0.38 8.72 0.33 2.44e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs6840360 0.571 rs11940881 chr4:152501050 C/G cg22705602 chr4:152727874 NA -0.32 -7.95 -0.3 8.32e-15 Intelligence (multi-trait analysis); BRCA cis rs1862618 0.671 rs2591958 chr5:56239369 C/G cg18230493 chr5:56204884 C5orf35 0.61 13.0 0.46 1.93e-34 Initial pursuit acceleration; BRCA cis rs11098499 0.866 rs12374244 chr4:120281972 A/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA trans rs617791 0.508 rs1047464 chr11:65769456 A/T cg17712092 chr4:129076599 LARP1B -0.48 -10.53 -0.38 4.9e-24 Breast cancer; BRCA cis rs2839186 0.771 rs13049175 chr21:47641326 G/A cg11766577 chr21:47581405 C21orf56 0.5 10.71 0.39 1.02e-24 Testicular germ cell tumor; BRCA cis rs35110281 0.743 rs230640 chr21:44914815 A/T cg04455712 chr21:45112962 RRP1B -0.41 -10.75 -0.39 7.07e-25 Mean corpuscular volume; BRCA cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg07930192 chr7:1003750 NA -0.47 -10.61 -0.39 2.51e-24 Longevity;Endometriosis; BRCA cis rs16976116 0.901 rs2899581 chr15:55491643 T/C cg11288833 chr15:55489084 RSL24D1 0.47 10.57 0.39 3.49e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3784262 0.669 rs12595180 chr15:58332541 G/C cg12031962 chr15:58353849 ALDH1A2 -0.37 -9.94 -0.37 9.69e-22 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11955398 0.716 rs2409792 chr5:59998236 A/G cg02684056 chr5:59996105 DEPDC1B 0.39 9.26 0.34 2.94e-19 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.906 rs113823909 chr8:58170635 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.34 -0.44 1.64e-31 Developmental language disorder (linguistic errors); BRCA cis rs7666738 0.830 rs10034619 chr4:98970067 G/C cg05340658 chr4:99064831 C4orf37 0.66 16.1 0.54 3.26e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.667 rs914197 chr21:45117439 A/G cg21573476 chr21:45109991 RRP1B -0.39 -10.23 -0.38 7.64e-23 Mean corpuscular volume; BRCA cis rs77741769 0.529 rs3213572 chr12:121205078 A/G cg02419362 chr12:121203948 SPPL3 -0.36 -8.32 -0.31 5.3e-16 Mean corpuscular volume; BRCA cis rs2404602 0.709 rs11072591 chr15:76649562 A/G cg23625390 chr15:77176239 SCAPER 0.51 12.6 0.45 1.12e-32 Blood metabolite levels; BRCA cis rs11190604 0.767 rs35508946 chr10:102191156 A/G cg07080220 chr10:102295463 HIF1AN 0.44 9.78 0.36 3.69e-21 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6951245 0.554 rs11761322 chr7:1151657 A/G cg24642844 chr7:1081250 C7orf50 -0.59 -12.22 -0.44 5.22e-31 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg19346786 chr7:2764209 NA -0.29 -8.87 -0.33 7.08e-18 Height; BRCA trans rs61931739 0.517 rs11611190 chr12:34015697 G/A cg26384229 chr12:38710491 ALG10B 0.67 14.03 0.49 3.66e-39 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs6834014 chr4:98951431 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.85 0.3 1.78e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs36051895 0.559 rs1590268 chr9:5209433 T/A cg02405213 chr9:5042618 JAK2 -0.43 -8.29 -0.31 6.61e-16 Pediatric autoimmune diseases; BRCA cis rs2070488 0.662 rs7373930 chr3:38454931 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.52 11.44 0.41 1.09e-27 Electrocardiographic conduction measures; BRCA cis rs769267 0.965 rs2017964 chr19:19387149 T/C cg03709012 chr19:19516395 GATAD2A 0.71 15.53 0.52 2.28e-46 Tonsillectomy; BRCA cis rs703842 0.616 rs7489290 chr12:58228588 C/G cg04478727 chr12:58166393 METTL1;FAM119B 0.43 8.02 0.3 5.24e-15 Multiple sclerosis; BRCA cis rs6570726 0.846 rs973856 chr6:145781916 C/T cg23711669 chr6:146136114 FBXO30 -0.65 -14.97 -0.51 1.19e-43 Lobe attachment (rater-scored or self-reported); BRCA cis rs6665290 0.935 rs6659424 chr1:227197875 A/G cg10327440 chr1:227177885 CDC42BPA -1.17 -49.4 -0.89 2.16e-220 Myeloid white cell count; BRCA cis rs3806843 0.966 rs11958868 chr5:140201420 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.44 -9.87 -0.36 1.83e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs2712184 0.967 rs1014680 chr2:217672824 A/G cg05032264 chr2:217675019 NA 0.44 10.77 0.39 5.94e-25 Glomerular filtration rate;Glomerular filtration rate in non diabetics (creatinine); BRCA cis rs9837602 1.000 rs704582 chr3:99571926 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.58 10.97 0.4 9.25e-26 Breast cancer; BRCA trans rs17685 0.753 rs10233282 chr7:75790081 C/T cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs2742234 0.590 rs2435383 chr10:43675671 T/C cg02780029 chr10:43622663 RET -0.35 -7.96 -0.3 7.99e-15 Hirschsprung disease; BRCA cis rs8072100 0.607 rs9894594 chr17:45461383 A/G cg25173405 chr17:45401733 C17orf57 -0.52 -10.73 -0.39 8.59e-25 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3771570 1.000 rs60604866 chr2:242352257 A/G cg21155796 chr2:242212141 HDLBP 0.59 8.97 0.33 3.19e-18 Prostate cancer; BRCA cis rs10751667 0.666 rs7944815 chr11:959776 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.63 0.55 7.59e-52 Alzheimer's disease (late onset); BRCA cis rs2180341 1.000 rs3798852 chr6:127636733 A/G cg27446573 chr6:127587934 RNF146 0.9 21.34 0.65 1.05e-76 Breast cancer; BRCA cis rs7827545 1.000 rs7008158 chr8:135565982 T/C cg17885191 chr8:135476712 NA 0.47 9.19 0.34 5.3e-19 Hypertension (SNP x SNP interaction); BRCA cis rs1003719 0.715 rs2835658 chr21:38565201 A/G cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.42 -0.5 4.91e-41 Eye color traits; BRCA cis rs2011503 0.941 rs17751061 chr19:19413092 C/T cg11584989 chr19:19387371 SF4 0.63 13.18 0.46 3.04e-35 Bipolar disorder; BRCA cis rs2739330 0.789 rs5760109 chr22:24252938 C/G cg20007245 chr22:24372913 LOC391322 -0.57 -12.78 -0.45 1.88e-33 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs6484504 0.576 rs208083 chr11:31196880 C/T cg06552810 chr11:31128660 NA -0.39 -8.7 -0.33 2.76e-17 Red blood cell count; BRCA cis rs7833986 0.501 rs72653948 chr8:56955689 A/G cg23139584 chr8:56987506 RPS20;SNORD54 0.66 12.58 0.45 1.35e-32 Height; BRCA cis rs7520050 0.966 rs10890363 chr1:46356148 C/T cg24296786 chr1:45957014 TESK2 -0.43 -9.58 -0.35 2.1e-20 Red blood cell count;Reticulocyte count; BRCA cis rs1801251 1.000 rs13003675 chr2:233584109 C/T cg25237894 chr2:233734115 C2orf82 0.39 11.31 0.41 3.6e-27 Coronary artery disease; BRCA cis rs1577917 0.740 rs9344533 chr6:86236188 C/A cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.44 13.01 0.46 1.78e-34 Response to antipsychotic treatment; BRCA cis rs1552244 1.000 rs7615646 chr3:10089773 A/C cg10729496 chr3:10149963 C3orf24 0.49 9.01 0.34 2.35e-18 Alzheimer's disease; BRCA cis rs875971 0.545 rs4718364 chr7:66001340 C/A cg11764359 chr7:65958608 NA 0.64 11.46 0.41 8.75e-28 Aortic root size; BRCA cis rs6121246 0.909 rs6119725 chr20:30385557 G/T cg21427119 chr20:30132790 HM13 -0.42 -8.89 -0.33 6.37e-18 Mean corpuscular hemoglobin; BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg04944784 chr2:26401820 FAM59B 0.96 16.87 0.56 4.16e-53 Gut microbiome composition (summer); BRCA cis rs2204008 0.729 rs2892365 chr12:38446760 G/C cg13010199 chr12:38710504 ALG10B -0.39 -8.36 -0.31 3.88e-16 Bladder cancer; BRCA cis rs12824058 0.831 rs12829373 chr12:130814114 G/C cg24229701 chr12:130821962 PIWIL1 0.39 8.95 0.33 3.76e-18 Menopause (age at onset); BRCA cis rs7917772 0.539 rs12572775 chr10:104285594 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.44 -12.89 -0.45 6.01e-34 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs875971 0.789 rs7808013 chr7:66071196 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -7.93 -0.3 9.87e-15 Aortic root size; BRCA cis rs1005277 0.638 rs1005278 chr10:38218748 G/A cg00409905 chr10:38381863 ZNF37A 0.48 9.55 0.35 2.64e-20 Extrinsic epigenetic age acceleration; BRCA cis rs3818285 0.504 rs7100154 chr10:111650150 T/C cg00817464 chr10:111662876 XPNPEP1 -0.32 -8.48 -0.32 1.61e-16 Superior crus of antihelix expression; BRCA cis rs2731664 0.721 rs2450333 chr5:176899546 G/A cg23176889 chr5:176863531 GRK6 -0.59 -15.55 -0.52 1.8e-46 Intelligence (multi-trait analysis); BRCA cis rs798554 0.757 rs1182171 chr7:2878510 A/G cg14863265 chr7:2801509 GNA12 -0.43 -9.24 -0.34 3.72e-19 Height; BRCA cis rs9527 0.521 rs12259163 chr10:104961477 A/G cg04362960 chr10:104952993 NT5C2 0.44 9.79 0.36 3.4e-21 Arsenic metabolism; BRCA cis rs4481887 1.000 rs4489592 chr1:248470697 A/T cg00666640 chr1:248458726 OR2T12 0.33 9.04 0.34 1.85e-18 Common traits (Other); BRCA cis rs2688608 0.530 rs71507081 chr10:75493136 G/A cg23231163 chr10:75533350 FUT11 -0.33 -8.65 -0.32 4.1e-17 Inflammatory bowel disease; BRCA cis rs2625529 0.689 rs12898868 chr15:72112918 A/G cg16672083 chr15:72433130 SENP8 0.63 14.74 0.5 1.59e-42 Red blood cell count; BRCA cis rs1355223 0.583 rs2941058 chr11:34880245 C/G cg11058730 chr11:34937778 PDHX;APIP 0.71 16.83 0.55 7.02e-53 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7904368 0.754 rs12246217 chr10:16853349 G/C cg14835575 chr10:16859367 RSU1 0.66 14.11 0.49 1.5e-39 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs9467773 1.000 rs6940188 chr6:26562029 G/C cg09904177 chr6:26538194 HMGN4 0.55 17.63 0.57 5.85e-57 Intelligence (multi-trait analysis); BRCA cis rs1153858 1.000 rs7179743 chr15:45638331 G/C cg21132104 chr15:45694354 SPATA5L1 0.7 15.45 0.52 5.52e-46 Homoarginine levels; BRCA cis rs875971 0.862 rs778724 chr7:65829291 T/C cg11764359 chr7:65958608 NA 0.77 17.32 0.57 2.26e-55 Aortic root size; BRCA cis rs12048904 0.505 rs11166508 chr1:101233511 A/G cg15686842 chr1:101360669 SLC30A7;EXTL2 -0.46 -9.98 -0.37 6.81e-22 Multiple sclerosis; BRCA cis rs2204008 0.540 rs1672425 chr12:38122842 G/A cg26384229 chr12:38710491 ALG10B -0.45 -10.4 -0.38 1.63e-23 Bladder cancer; BRCA cis rs735860 0.712 rs3736732 chr6:53160383 G/T cg10236188 chr6:53219634 NA -0.41 -8.77 -0.33 1.64e-17 Glaucoma; BRCA cis rs7100689 0.646 rs12253992 chr10:82158710 G/A cg01528321 chr10:82214614 TSPAN14 0.85 18.93 0.6 8.63e-64 Post bronchodilator FEV1; BRCA cis rs798554 0.679 rs2533870 chr7:2885274 C/G cg19346786 chr7:2764209 NA 0.32 9.77 0.36 4.33e-21 Height; BRCA cis rs56399783 0.901 rs73033403 chr7:2877941 G/A cg19731401 chr7:2775893 GNA12 0.54 8.25 0.31 9.25e-16 Childhood ear infection; BRCA cis rs4722166 0.532 rs4719712 chr7:22755807 C/T cg05472934 chr7:22766657 IL6 0.43 10.62 0.39 2.26e-24 Lung cancer; BRCA cis rs9291683 0.530 rs13115193 chr4:9982191 C/T cg11266682 chr4:10021025 SLC2A9 0.41 10.75 0.39 7.02e-25 Bone mineral density; BRCA cis rs7493 1.000 rs17166875 chr7:95041271 C/T cg21856205 chr7:94953877 PON1 -0.37 -8.03 -0.3 4.74e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs6748734 0.779 rs6437371 chr2:241797424 G/C cg07537917 chr2:241836409 C2orf54 -0.43 -10.45 -0.38 1.04e-23 Urinary metabolites; BRCA cis rs6089584 0.819 rs1467593 chr20:60601432 T/G cg06108461 chr20:60628389 TAF4 0.91 16.91 0.56 2.66e-53 Body mass index; BRCA cis rs490234 0.702 rs1891035 chr9:128258684 T/C cg14078157 chr9:128172775 NA -0.53 -11.75 -0.42 5.48e-29 Mean arterial pressure; BRCA trans rs9291683 0.530 rs17246501 chr4:9985710 A/C cg26043149 chr18:55253948 FECH 0.41 9.09 0.34 1.28e-18 Bone mineral density; BRCA cis rs7520050 0.966 rs12561806 chr1:46396776 C/T cg24296786 chr1:45957014 TESK2 0.44 9.8 0.36 3.19e-21 Red blood cell count;Reticulocyte count; BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg08888203 chr3:10149979 C3orf24 0.65 13.64 0.47 2.35e-37 Alzheimer's disease; BRCA cis rs9790314 0.905 rs4518145 chr3:160950030 T/C cg03342759 chr3:160939853 NMD3 -0.65 -14.19 -0.49 6.54e-40 Morning vs. evening chronotype; BRCA cis rs6582630 0.519 rs4294627 chr12:38293982 C/T cg26384229 chr12:38710491 ALG10B 0.73 17.15 0.56 1.68e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs7666738 0.962 rs11728816 chr4:98951767 C/T cg03676636 chr4:99064102 C4orf37 0.24 8.26 0.31 8.47e-16 Colonoscopy-negative controls vs population controls; BRCA cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg24812749 chr6:127587940 RNF146 0.66 14.88 0.51 3.15e-43 Breast cancer; BRCA cis rs2070488 0.965 rs2366119 chr3:38484453 C/T cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.75 20.85 0.64 4.81e-74 Electrocardiographic conduction measures; BRCA cis rs3820928 0.874 rs9288618 chr2:227872617 A/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.37 -0.31 3.61e-16 Pulmonary function; BRCA cis rs12310956 0.532 rs10844720 chr12:33987859 G/T cg06521331 chr12:34319734 NA -0.56 -10.84 -0.39 2.95e-25 Morning vs. evening chronotype; BRCA cis rs1552244 0.882 rs13064570 chr3:9997545 G/C cg08888203 chr3:10149979 C3orf24 0.59 12.1 0.43 1.67e-30 Alzheimer's disease; BRCA cis rs8114671 0.562 rs6120763 chr20:33506400 C/G cg24642439 chr20:33292090 TP53INP2 0.43 9.11 0.34 1.03e-18 Height; BRCA cis rs4819052 1.000 rs13047688 chr21:46669290 G/A cg02159808 chr21:46707872 POFUT2;LOC642852 0.61 11.1 0.4 2.69e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2762353 0.595 rs1892256 chr6:25754271 C/T cg03517284 chr6:25882590 NA 0.69 15.83 0.53 7.39e-48 Blood metabolite levels; BRCA cis rs9815354 0.904 rs73081347 chr3:41903582 T/C cg03022575 chr3:42003672 ULK4 0.71 9.74 0.36 5.4e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs4268898 0.735 rs12469585 chr2:24489054 A/T cg06627628 chr2:24431161 ITSN2 0.41 8.63 0.32 4.96e-17 Asthma; BRCA cis rs911119 0.955 rs12625716 chr20:23606845 A/G cg16589663 chr20:23618590 CST3 -0.43 -8.05 -0.3 4.04e-15 Chronic kidney disease; BRCA cis rs765787 0.530 rs2413780 chr15:45538866 A/G cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.02e-15 Uric acid levels; BRCA cis rs9733 0.687 rs11204735 chr1:150841667 T/C cg13175981 chr1:150552382 MCL1 0.41 9.04 0.34 1.79e-18 Tonsillectomy; BRCA cis rs67311347 1.000 rs17078511 chr3:40396254 A/G cg09455208 chr3:40491958 NA 0.41 9.77 0.36 4.33e-21 Renal cell carcinoma; BRCA cis rs7772486 0.754 rs10872580 chr6:146140281 C/T cg13319975 chr6:146136371 FBXO30 0.43 10.01 0.37 5.43e-22 Lobe attachment (rater-scored or self-reported); BRCA cis rs7119038 0.509 rs10892256 chr11:118578705 G/A cg19308663 chr11:118741387 NA 0.38 8.53 0.32 1.1e-16 Sjögren's syndrome; BRCA cis rs7577696 0.524 rs61399065 chr2:32208554 G/A cg02381751 chr2:32503542 YIPF4 -0.43 -8.03 -0.3 4.82e-15 Inflammatory biomarkers; BRCA cis rs2559856 0.967 rs7970837 chr12:102081576 A/G cg12924262 chr12:102091054 CHPT1 0.36 8.16 0.31 1.82e-15 Blood protein levels; BRCA cis rs651907 0.535 rs1460097 chr3:101497569 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.44 -0.32 2.15e-16 Colorectal cancer; BRCA cis rs7044106 0.537 rs4434680 chr9:123489688 A/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.62 12.26 0.44 3.39e-31 Hip circumference adjusted for BMI; BRCA cis rs2153535 0.580 rs4960413 chr6:8438466 C/T cg07606381 chr6:8435919 SLC35B3 0.65 14.36 0.49 1e-40 Motion sickness; BRCA trans rs11098499 0.644 rs10012252 chr4:120559139 T/C cg25214090 chr10:38739885 LOC399744 0.44 9.98 0.37 6.57e-22 Corneal astigmatism; BRCA cis rs6952808 0.609 rs12699453 chr7:1953056 C/T cg02951883 chr7:2050386 MAD1L1 -0.38 -9.11 -0.34 1.06e-18 Bipolar disorder and schizophrenia; BRCA trans rs11146838 1 rs11146838 chr10:39149977 A/T cg25373794 chr1:162760220 HSD17B7 -0.41 -8.06 -0.3 3.89e-15 Breast cancer; BRCA cis rs7552404 0.727 rs12093623 chr1:76256232 T/G cg10523679 chr1:76189770 ACADM 0.71 13.01 0.46 1.74e-34 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs910316 0.737 rs175072 chr14:75502827 T/C cg08847533 chr14:75593920 NEK9 -0.85 -21.31 -0.64 1.61e-76 Height; BRCA cis rs1710278 0.904 rs1278261 chr10:127746275 C/G cg22975853 chr10:127789788 ADAM12 0.3 7.91 0.3 1.17e-14 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs765787 0.530 rs28733848 chr15:45516047 C/T cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA cis rs72781680 0.848 rs2339926 chr2:24045734 C/G cg20701182 chr2:24300061 SF3B14 0.58 9.11 0.34 1.04e-18 Lymphocyte counts; BRCA trans rs61931739 0.534 rs4931775 chr12:34050729 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.57 0.35 2.29e-20 Morning vs. evening chronotype; BRCA trans rs853679 0.546 rs2232423 chr6:28366151 A/G cg06606381 chr12:133084897 FBRSL1 -0.9 -8.84 -0.33 9.38e-18 Depression; BRCA cis rs13118159 0.742 rs7679860 chr4:1333987 C/T cg20887711 chr4:1340912 KIAA1530 0.45 10.52 0.38 5.44e-24 Longevity; BRCA cis rs35306767 0.761 rs11253559 chr10:1044809 T/C cg10556349 chr10:835070 NA 0.59 8.09 0.3 3.05e-15 Eosinophil percentage of granulocytes; BRCA cis rs597539 0.652 rs513359 chr11:68669496 A/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 -0.74 -18.14 -0.58 1.29e-59 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.47 8.36 0.31 4.07e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs11785258 chr8:58132893 A/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs13102973 0.864 rs7442176 chr4:135899575 C/A cg14419869 chr4:135874104 NA -0.52 -10.64 -0.39 1.87e-24 Subjective well-being; BRCA cis rs4363385 0.818 rs6587719 chr1:152993409 G/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.36 -0.31 3.81e-16 Inflammatory skin disease; BRCA cis rs6831352 0.918 rs17217949 chr4:100054312 A/G cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA cis rs3096299 0.679 rs3096322 chr16:89441123 A/G cg06640241 chr16:89574553 SPG7 -0.52 -11.1 -0.4 2.66e-26 Multiple myeloma (IgH translocation); BRCA cis rs9815354 0.812 rs73071330 chr3:41810553 T/G cg03022575 chr3:42003672 ULK4 0.72 9.84 0.36 2.33e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs7264396 0.561 rs6060750 chr20:34596371 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.53 -10.81 -0.39 4.05e-25 Total cholesterol levels; BRCA cis rs4268898 0.662 rs72793208 chr2:24510284 C/T cg06627628 chr2:24431161 ITSN2 -0.78 -14.9 -0.51 2.64e-43 Asthma; BRCA cis rs1008375 0.800 rs28754811 chr4:17612312 C/T cg04450456 chr4:17643702 FAM184B 0.36 10.6 0.39 2.63e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs651907 0.557 rs35850993 chr3:101437433 A/G cg12386194 chr3:101231763 SENP7 0.41 8.81 0.33 1.19e-17 Colorectal cancer; BRCA cis rs2836950 0.545 rs2836952 chr21:40616651 G/C cg17971929 chr21:40555470 PSMG1 -0.48 -10.73 -0.39 8.59e-25 Menarche (age at onset); BRCA cis rs12711979 1.000 rs6542655 chr2:3872434 T/C cg17052675 chr2:3827356 NA -0.43 -11.55 -0.42 3.63e-28 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs910316 0.967 rs4899550 chr14:75647666 C/T cg11812906 chr14:75593930 NEK9 -0.58 -13.02 -0.46 1.49e-34 Height; BRCA cis rs4423214 0.840 rs1792227 chr11:71177412 A/G cg05163923 chr11:71159392 DHCR7 -0.57 -11.6 -0.42 2.31e-28 Vitamin D levels; BRCA cis rs17092148 0.887 rs6059919 chr20:33151545 G/T cg16810054 chr20:33298113 TP53INP2 -0.48 -10.31 -0.38 3.66e-23 Neuroticism; BRCA cis rs28493229 0.522 rs17713068 chr19:41270055 A/C cg21869046 chr19:41225005 ITPKC 0.38 9.74 0.36 5.4e-21 Kawasaki disease; BRCA cis rs7639513 0.590 rs3729931 chr3:12626516 A/G cg23032965 chr3:12705835 RAF1 -0.59 -12.53 -0.44 2.32e-32 Itch intensity from mosquito bite; BRCA cis rs12612619 0.732 rs7585410 chr2:27202120 A/G cg00617064 chr2:27272375 NA -0.32 -8.37 -0.31 3.53e-16 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs8062405 1.000 rs61737565 chr16:28855522 G/C cg09754948 chr16:28834200 ATXN2L 0.45 8.9 0.33 5.77e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs12477438 0.765 rs6735801 chr2:99657995 G/T cg08885076 chr2:99613938 TSGA10 -0.52 -11.8 -0.42 3.27e-29 Chronic sinus infection; BRCA cis rs870825 0.616 rs7678949 chr4:185635018 G/C cg04058563 chr4:185651563 MLF1IP 0.78 17.56 0.57 1.28e-56 Blood protein levels; BRCA cis rs4819052 1.000 rs9306123 chr21:46709922 A/G cg19498844 chr21:46707878 POFUT2;LOC642852 0.74 14.9 0.51 2.58e-43 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 -0.62 -14.06 -0.49 2.6e-39 Platelet count; BRCA cis rs1707322 1.000 rs11211205 chr1:46321874 C/T cg06784218 chr1:46089804 CCDC17 0.44 10.65 0.39 1.65e-24 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs12477438 0.765 rs6750876 chr2:99679673 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.56 -12.33 -0.44 1.69e-31 Chronic sinus infection; BRCA cis rs796364 0.951 rs6722092 chr2:201059371 G/T cg23649088 chr2:200775458 C2orf69 0.62 10.94 0.4 1.21e-25 Schizophrenia; BRCA cis rs6831352 0.879 rs67311928 chr4:100048999 A/G cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs7267979 1.000 rs2258769 chr20:25276680 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.71 0.36 7.2e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs12950390 0.853 rs17773010 chr17:45858297 C/T cg24803719 chr17:45855879 NA -0.32 -8.35 -0.31 4.14e-16 IgG glycosylation; BRCA cis rs9420 0.961 rs499188 chr11:57434122 C/A cg19752551 chr11:57585705 CTNND1 -0.41 -10.38 -0.38 1.92e-23 Schizophrenia; BRCA cis rs11122272 0.735 rs2749717 chr1:231489353 G/T cg23162821 chr1:231664172 TSNAX-DISC1;TSNAX -0.48 -11.68 -0.42 1.06e-28 Hemoglobin concentration; BRCA cis rs17685 0.753 rs10085567 chr7:75734206 A/C cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.41 -0.35 8.79e-20 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs11098499 0.954 rs10031665 chr4:120422852 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -8.03 -0.3 4.53e-15 Corneal astigmatism; BRCA cis rs6912958 0.559 rs242280 chr6:88048714 G/A cg12350822 chr6:88032061 C6orf162;GJB7 0.39 11.32 0.41 3.23e-27 Monocyte percentage of white cells; BRCA cis rs2836974 0.931 rs13047663 chr21:40708818 C/T cg17971929 chr21:40555470 PSMG1 0.74 15.42 0.52 7.52e-46 Cognitive function; BRCA cis rs10206020 0.885 rs11885392 chr2:1578182 C/A cg12573674 chr2:1569213 NA -0.56 -12.07 -0.43 2.35e-30 IgG glycosylation; BRCA cis rs6598955 0.671 rs11247884 chr1:26577338 C/T cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs4434138 0.533 rs11130324 chr3:52770310 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.28 9.08 0.34 1.28e-18 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.662 rs6058146 chr20:33540529 A/G cg07148914 chr20:33460835 GGT7 0.44 9.61 0.36 1.63e-20 Height; BRCA trans rs11098499 0.866 rs7665125 chr4:120402079 G/T cg25214090 chr10:38739885 LOC399744 0.46 10.68 0.39 1.28e-24 Corneal astigmatism; BRCA cis rs3096299 0.563 rs4600467 chr16:89562516 C/T cg08392591 chr16:89556376 ANKRD11 0.47 11.25 0.41 6.25e-27 Multiple myeloma (IgH translocation); BRCA cis rs8017423 0.605 rs3742673 chr14:90735707 C/T cg14092571 chr14:90743983 NA -0.38 -9.55 -0.35 2.73e-20 Mortality in heart failure; BRCA cis rs1862618 0.853 rs832583 chr5:56178217 A/C cg22800045 chr5:56110881 MAP3K1 0.65 12.21 0.43 5.84e-31 Initial pursuit acceleration; BRCA cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg12311346 chr5:56204834 C5orf35 -0.73 -14.67 -0.5 3.42e-42 Initial pursuit acceleration; BRCA cis rs2694528 0.686 rs6864253 chr5:59862743 A/G cg11474532 chr5:59995715 DEPDC1B 0.63 9.46 0.35 5.7e-20 Parkinson's disease; BRCA cis rs910316 0.967 rs11159121 chr14:75666029 A/T cg11812906 chr14:75593930 NEK9 -0.6 -14.03 -0.49 3.71e-39 Height; BRCA cis rs13191362 0.935 rs35049401 chr6:162968464 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.87 12.7 0.45 3.91e-33 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs11098499 0.863 rs34308924 chr4:120481431 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.71 0.42 7.51e-29 Corneal astigmatism; BRCA cis rs2404602 0.647 rs7181506 chr15:76935677 G/T cg23625390 chr15:77176239 SCAPER 0.48 11.45 0.41 9.27e-28 Blood metabolite levels; BRCA cis rs1862618 0.641 rs170733 chr5:56249251 A/G cg20203395 chr5:56204925 C5orf35 0.39 8.57 0.32 8.02e-17 Initial pursuit acceleration; BRCA cis rs936229 0.749 rs6495126 chr15:75175026 C/T cg10253484 chr15:75165896 SCAMP2 0.61 12.03 0.43 3.51e-30 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs7918232 0.941 rs7096505 chr10:27326999 T/C cg14240646 chr10:27532245 ACBD5 -0.63 -9.93 -0.37 1.05e-21 Breast cancer; BRCA cis rs4689388 0.750 rs12642481 chr4:6301058 G/A cg25554036 chr4:6271136 WFS1 0.38 8.61 0.32 5.8e-17 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs1538970 0.962 rs3219489 chr1:45797505 C/G cg05343316 chr1:45956843 TESK2 0.52 9.7 0.36 7.47e-21 Platelet count; BRCA cis rs6987853 0.736 rs6991995 chr8:42436219 A/C cg09913449 chr8:42400586 C8orf40 0.42 9.27 0.34 2.81e-19 Mean corpuscular hemoglobin concentration; BRCA cis rs6582630 0.537 rs35336822 chr12:38346251 T/C cg26384229 chr12:38710491 ALG10B 0.69 16.06 0.54 5.54e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs10504229 0.683 rs11787247 chr8:58131528 G/T cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs10464366 0.544 rs4355688 chr7:39158402 C/T cg20302533 chr7:39170763 POU6F2 0.38 8.06 0.3 3.78e-15 IgG glycosylation; BRCA cis rs9733 0.596 rs11204697 chr1:150658971 C/T cg18016565 chr1:150552671 MCL1 0.35 8.25 0.31 9.22e-16 Tonsillectomy; BRCA cis rs6545883 0.826 rs777590 chr2:61417145 C/G cg15711740 chr2:61764176 XPO1 -0.52 -13.11 -0.46 5.93e-35 Tuberculosis; BRCA cis rs7246657 0.722 rs1975937 chr19:38091932 A/T cg18154014 chr19:37997991 ZNF793 0.49 9.35 0.35 1.42e-19 Coronary artery calcification; BRCA cis rs739401 0.611 rs10833048 chr11:3020040 A/G cg08508325 chr11:3079039 CARS -0.41 -14.29 -0.49 2.15e-40 Longevity; BRCA cis rs4665809 0.590 rs3806515 chr2:26466975 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs6163 0.727 rs284862 chr10:104572081 C/T cg04362960 chr10:104952993 NT5C2 -0.35 -8.08 -0.3 3.36e-15 Waist circumference;Hip circumference; BRCA cis rs9811920 0.638 rs2452321 chr3:99638836 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.69 16.09 0.54 3.63e-49 Axial length; BRCA trans rs2270927 0.510 rs7730153 chr5:75579762 A/G cg13563193 chr19:33072644 PDCD5 -0.77 -9.55 -0.35 2.71e-20 Mean corpuscular volume; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg02592271 chr2:27665507 KRTCAP3 -0.32 -7.98 -0.3 6.6e-15 Total body bone mineral density; BRCA cis rs7246657 1.000 rs7246657 chr19:37747108 C/T cg14683738 chr19:37701593 ZNF585B -0.48 -8.37 -0.31 3.73e-16 Coronary artery calcification; BRCA cis rs17253792 0.822 rs74824071 chr14:56095142 T/G cg01858014 chr14:56050164 KTN1 -0.76 -10.46 -0.38 9.82e-24 Putamen volume; BRCA cis rs2836974 0.602 rs8130854 chr21:40707041 G/A cg11890956 chr21:40555474 PSMG1 -0.81 -19.26 -0.61 1.65e-65 Cognitive function; BRCA cis rs17270561 0.609 rs4711096 chr6:25727054 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.89 0.33 6.45e-18 Iron status biomarkers; BRCA cis rs736408 0.716 rs2239549 chr3:52823126 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.32 10.13 0.37 1.84e-22 Bipolar disorder; BRCA trans rs75804782 0.521 rs72993074 chr2:239413582 T/G cg01134436 chr17:81009848 B3GNTL1 0.67 8.56 0.32 8.1e-17 Morning vs. evening chronotype;Chronotype; BRCA cis rs944002 1.000 rs2297067 chr14:103566785 A/G cg01104208 chr14:103566172 C14orf73 0.45 8.83 0.33 1.02e-17 Gamma gluatamyl transferase levels;Liver enzyme levels (gamma-glutamyl transferase);Mean platelet volume; BRCA trans rs1493916 1.000 rs9964702 chr18:31390427 A/C cg27147174 chr7:100797783 AP1S1 -0.54 -10.87 -0.4 2.35e-25 Life satisfaction; BRCA cis rs56399783 0.901 rs12540539 chr7:2873294 C/T cg19731401 chr7:2775893 GNA12 0.54 8.25 0.31 9.25e-16 Childhood ear infection; BRCA cis rs9649465 0.967 rs11765790 chr7:123293152 A/C cg04330084 chr7:123175371 IQUB -0.31 -8.48 -0.32 1.51e-16 Migraine; BRCA cis rs2836950 0.565 rs2836945 chr21:40596757 C/T cg11644478 chr21:40555479 PSMG1 -0.51 -10.84 -0.39 3.1e-25 Menarche (age at onset); BRCA trans rs6598955 0.671 rs11247908 chr1:26638222 G/A cg07461501 chr17:79650226 HGS;ARL16 -0.63 -13.94 -0.48 9.76e-39 Obesity-related traits; BRCA cis rs7412746 0.658 rs11582281 chr1:150826831 T/C cg15448220 chr1:150897856 SETDB1 0.35 7.82 0.3 2.21e-14 Melanoma; BRCA cis rs400736 0.602 rs11121090 chr1:8168634 A/G cg25007680 chr1:8021821 PARK7 0.35 8.78 0.33 1.55e-17 Response to antidepressants and depression; BRCA cis rs3815700 1.000 rs7248273 chr19:33096816 C/T cg02997394 chr19:33096574 ANKRD27 0.66 10.2 0.37 1.01e-22 Eosinophilic esophagitis; BRCA trans rs1973993 0.561 rs3862908 chr1:96987042 G/A cg10631902 chr5:14652156 NA -0.39 -9.83 -0.36 2.46e-21 Weight; BRCA trans rs2204008 0.688 rs12824232 chr12:38175901 G/A cg06521331 chr12:34319734 NA -0.54 -9.71 -0.36 6.9e-21 Bladder cancer; BRCA cis rs6860806 0.695 rs11952099 chr5:131576772 A/G cg18758796 chr5:131593413 PDLIM4 0.34 8.76 0.33 1.72e-17 Breast cancer; BRCA cis rs7593730 0.537 rs6711375 chr2:161090873 G/A cg22609984 chr2:161126801 NA 0.39 8.59 0.32 6.56e-17 Type 2 diabetes; BRCA cis rs7772486 0.875 rs864390 chr6:146315035 G/T cg23711669 chr6:146136114 FBXO30 0.64 14.65 0.5 4.06e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs4713118 0.869 rs6922574 chr6:27693003 A/T cg26587870 chr6:27730563 NA -0.39 -8.31 -0.31 5.84e-16 Parkinson's disease; BRCA cis rs7264396 0.563 rs6058302 chr20:34290037 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.12 -0.43 1.38e-30 Total cholesterol levels; BRCA cis rs1707322 1.000 rs785498 chr1:46592414 C/T cg03146154 chr1:46216737 IPP -0.43 -9.08 -0.34 1.39e-18 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs477895 0.653 rs11231701 chr11:63893702 G/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 8.7 0.33 2.9e-17 Mean platelet volume; BRCA cis rs4927850 0.709 rs6783079 chr3:195652708 T/C cg00031303 chr3:195681400 NA 0.72 12.11 0.43 1.57e-30 Pancreatic cancer; BRCA cis rs2250402 0.510 rs2291621 chr15:40324837 C/T cg10636054 chr15:40330586 SRP14 0.84 12.29 0.44 2.62e-31 Corneal curvature; BRCA cis rs7131987 0.641 rs2015599 chr12:29435480 G/A cg09582351 chr12:29534625 ERGIC2 -0.34 -8.37 -0.31 3.63e-16 QT interval; BRCA cis rs4727027 0.866 rs7778766 chr7:148806729 A/G cg15662616 chr7:148823355 ZNF425;ZNF398 0.36 8.18 0.31 1.53e-15 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4953318 0.894 rs10495928 chr2:46353166 A/G cg12428440 chr2:46370979 PRKCE 0.4 9.44 0.35 6.98e-20 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg20644253 chr19:19431407 KIAA0892;SF4 0.59 11.95 0.43 7.69e-30 Tonsillectomy; BRCA cis rs12142240 0.698 rs10158130 chr1:46822600 T/C cg00530320 chr1:46809349 NSUN4 0.49 9.78 0.36 3.91e-21 Menopause (age at onset); BRCA cis rs13118159 0.550 rs4974612 chr4:1364543 A/G cg19318889 chr4:1322082 MAEA 0.58 12.1 0.43 1.71e-30 Longevity; BRCA trans rs7618501 1.000 rs9855505 chr3:49792158 T/G cg21582582 chr3:182698605 DCUN1D1 -0.39 -10.12 -0.37 2e-22 Intelligence (multi-trait analysis); BRCA cis rs9858542 0.953 rs11926781 chr3:49603289 C/T cg03060546 chr3:49711283 APEH -0.53 -10.54 -0.38 4.55e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7772486 0.597 rs7746618 chr6:146281367 T/C cg05347473 chr6:146136440 FBXO30 -0.59 -11.22 -0.41 8.96e-27 Lobe attachment (rater-scored or self-reported); BRCA cis rs7707921 0.846 rs4293895 chr5:81425592 T/C cg15871215 chr5:81402204 ATG10 -0.41 -8.73 -0.33 2.15e-17 Breast cancer; BRCA cis rs6763687 0.856 rs9862371 chr3:171803226 G/T cg16233210 chr3:171778391 FNDC3B -0.43 -10.28 -0.38 4.88e-23 Red cell distribution width; BRCA cis rs79839061 0.656 rs3775126 chr4:886345 C/T cg14530993 chr4:882597 GAK 0.57 10.19 0.37 1.09e-22 Intelligence (multi-trait analysis); BRCA cis rs3858526 0.508 rs10838734 chr11:5876325 T/G cg02574844 chr11:5959923 NA -0.42 -8.84 -0.33 9.53e-18 DNA methylation (variation); BRCA cis rs7044106 0.762 rs7024046 chr9:123419178 G/A cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 14.08 0.49 1.97e-39 Hip circumference adjusted for BMI; BRCA cis rs3784262 0.631 rs4646560 chr15:58353546 C/G cg12031962 chr15:58353849 ALDH1A2 -0.38 -10.27 -0.38 5.35e-23 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs11676348 0.818 rs7423433 chr2:218985084 G/A cg06547715 chr2:218990976 CXCR2 0.32 7.89 0.3 1.3e-14 Ulcerative colitis; BRCA cis rs826838 1.000 rs826851 chr12:39112639 A/G cg13010199 chr12:38710504 ALG10B -0.44 -10.53 -0.38 5.29e-24 Heart rate; BRCA cis rs4665809 0.531 rs3892649 chr2:26457267 T/G cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.85 0.36 2.04e-21 Gut microbiome composition (summer); BRCA trans rs561341 1.000 rs72825712 chr17:30316119 A/T cg20587970 chr11:113659929 NA -1.34 -24.68 -0.7 5.51e-95 Hip circumference adjusted for BMI; BRCA cis rs17376456 0.877 rs10057814 chr5:93399092 C/G cg25358565 chr5:93447407 FAM172A 1.17 18.68 0.59 1.81e-62 Diabetic retinopathy; BRCA trans rs12517041 1.000 rs4701363 chr5:23301008 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.83 -0.3 2.03e-14 Calcium levels; BRCA cis rs9649213 0.593 rs7812180 chr7:97969140 A/G cg01877450 chr7:97915802 BRI3 0.39 8.13 0.31 2.23e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.616 rs6957733 chr7:1106327 T/G cg15112475 chr7:1198522 ZFAND2A -0.38 -8.89 -0.33 6.26e-18 Longevity;Endometriosis; BRCA cis rs67478160 0.643 rs2024667 chr14:104211529 T/G cg01849466 chr14:104193079 ZFYVE21 -0.43 -11.13 -0.4 1.99e-26 Schizophrenia; BRCA cis rs7727544 0.548 rs4705938 chr5:131694077 A/G cg14196790 chr5:131705035 SLC22A5 0.5 13.19 0.46 2.56e-35 Blood metabolite levels; BRCA cis rs71636778 0.722 rs116491347 chr1:27172684 C/T cg12203394 chr1:27248618 NUDC 0.53 8.52 0.32 1.17e-16 Monocyte percentage of white cells;Granulocyte percentage of myeloid white cells; BRCA cis rs4927850 1.000 rs7625570 chr3:195747398 A/G cg01181863 chr3:195395398 SDHAP2 -0.46 -8.16 -0.31 1.73e-15 Pancreatic cancer; BRCA cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg16586182 chr3:47516702 SCAP 0.44 8.9 0.33 5.67e-18 Birth weight; BRCA cis rs7666738 0.830 rs17483521 chr4:98974058 A/T cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.863 rs3775854 chr4:120471971 C/T cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs12188164 0.543 rs890972 chr5:462465 C/A cg16584290 chr5:462447 EXOC3 0.54 15.14 0.51 1.72e-44 Cystic fibrosis severity; BRCA cis rs13256369 1.000 rs4840351 chr8:8573148 A/G cg18904891 chr8:8559673 CLDN23 0.61 12.08 0.43 2.19e-30 Obesity-related traits; BRCA cis rs9747201 1.000 rs9747201 chr17:80177852 A/C cg01777586 chr17:80163174 CCDC57 0.39 8.03 0.3 4.64e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs4555082 0.874 rs2245329 chr14:105719181 T/C cg06808227 chr14:105710500 BRF1 -0.79 -16.39 -0.54 1.17e-50 Mean platelet volume;Platelet distribution width; BRCA cis rs7829975 0.572 rs7005000 chr8:8796602 A/G cg15556689 chr8:8085844 FLJ10661 -0.41 -11.36 -0.41 2.19e-27 Mood instability; BRCA cis rs7662987 0.517 rs2602877 chr4:100039847 T/A cg13256891 chr4:100009986 ADH5 0.53 9.84 0.36 2.22e-21 Smoking initiation; BRCA cis rs4665809 0.590 rs11897162 chr2:26503654 T/C cg26119090 chr2:26468346 HADHA;HADHB 0.94 20.32 0.63 3.65e-71 Gut microbiome composition (summer); BRCA cis rs936229 1.000 rs936228 chr15:75132164 T/C cg10253484 chr15:75165896 SCAMP2 -0.53 -9.92 -0.37 1.1e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs6831352 0.725 rs2602846 chr4:100025151 T/A cg13256891 chr4:100009986 ADH5 0.54 10.01 0.37 5.06e-22 Alcohol dependence; BRCA cis rs35110281 0.748 rs162403 chr21:44963365 C/G cg21573476 chr21:45109991 RRP1B -0.36 -9.14 -0.34 8.31e-19 Mean corpuscular volume; BRCA cis rs3768617 0.811 rs10911232 chr1:183052533 C/T ch.1.3577855R chr1:183094577 LAMC1 0.42 9.34 0.35 1.52e-19 Fuchs's corneal dystrophy; BRCA cis rs910873 0.505 rs6059961 chr20:33231490 T/C cg16810054 chr20:33298113 TP53INP2 -0.47 -10.19 -0.37 1.1e-22 Melanoma; BRCA cis rs6840360 0.571 rs62327269 chr4:152527973 G/C cg22705602 chr4:152727874 NA -0.32 -8.0 -0.3 6.04e-15 Intelligence (multi-trait analysis); BRCA cis rs921968 0.541 rs6717433 chr2:219375711 G/C cg10223061 chr2:219282414 VIL1 0.29 8.04 0.3 4.22e-15 Mean corpuscular hemoglobin concentration; BRCA cis rs7811142 0.830 rs76798830 chr7:99952828 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.95 15.12 0.51 2.34e-44 Platelet count; BRCA cis rs6582630 0.555 rs7301250 chr12:38596244 G/T cg26384229 chr12:38710491 ALG10B 0.69 16.07 0.54 4.72e-49 Drug-induced liver injury (flucloxacillin); BRCA cis rs7793919 0.652 rs10228886 chr7:4783224 C/T cg09789173 chr7:4769017 FOXK1 -0.49 -11.43 -0.41 1.2e-27 Mosquito bite size; BRCA cis rs6860806 0.507 rs156322 chr5:131653925 C/T cg07395648 chr5:131743802 NA -0.36 -7.89 -0.3 1.28e-14 Breast cancer; BRCA cis rs7267979 0.714 rs6115107 chr20:25237390 A/G cg08601574 chr20:25228251 PYGB 0.34 8.1 0.3 2.89e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9399135 0.933 rs41294852 chr6:135376379 T/G cg24558204 chr6:135376177 HBS1L 0.44 12.19 0.43 7.21e-31 Red blood cell count; BRCA cis rs881375 0.967 rs2109896 chr9:123683106 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.41 8.35 0.31 4.13e-16 Rheumatoid arthritis; BRCA trans rs877282 1.000 rs12775643 chr10:773242 G/A cg22713356 chr15:30763199 NA 1.17 24.0 0.69 3.28e-91 Uric acid levels; BRCA trans rs9325144 0.647 rs7957185 chr12:38909710 G/A cg23762105 chr12:34175262 ALG10 0.38 8.65 0.32 4.26e-17 Morning vs. evening chronotype; BRCA cis rs2153535 0.601 rs2143353 chr6:8530111 T/G cg07606381 chr6:8435919 SLC35B3 0.65 14.41 0.5 5.45e-41 Motion sickness; BRCA cis rs1577917 1.000 rs1999852 chr6:86705738 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.46 -12.42 -0.44 7.23e-32 Response to antipsychotic treatment; BRCA cis rs7904368 0.806 rs7900527 chr10:16857992 C/G cg23933602 chr10:16859644 RSU1 0.55 8.99 0.33 2.88e-18 Ratio of the peak velocity of the mitral E-Wave divided by the peak velocity of the mitral A-wave.; BRCA cis rs798554 0.757 rs1713919 chr7:2864706 C/A cg14863265 chr7:2801509 GNA12 -0.45 -9.67 -0.36 9.74e-21 Height; BRCA cis rs7666738 0.830 rs7678911 chr4:99057430 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.37 0.57 1.21e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs2645694 0.626 rs904050 chr4:77826089 T/G cg18351406 chr4:77819688 ANKRD56 0.61 13.39 0.47 3.29e-36 Emphysema distribution in smoking; BRCA cis rs943466 1.000 rs61394483 chr6:33751945 G/A cg25922239 chr6:33757077 LEMD2 -0.38 -7.84 -0.3 1.9e-14 Body mass index (joint analysis main effects and physical activity interaction);Body mass index; BRCA cis rs9287719 0.967 rs12692417 chr2:10745718 C/G cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.56e-23 Prostate cancer; BRCA cis rs2115630 0.905 rs1975277 chr15:85329558 C/T cg12863693 chr15:85201151 NMB -0.38 -9.01 -0.34 2.42e-18 P wave terminal force; BRCA cis rs2439831 0.850 rs7169322 chr15:44131014 T/C cg02155558 chr15:43621948 ADAL;LCMT2 0.74 12.75 0.45 2.5e-33 Lung cancer in ever smokers; BRCA cis rs60843830 0.964 rs17713568 chr2:242132 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.79 18.57 0.59 7.01e-62 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2032447 0.517 rs7767546 chr6:25904067 T/C cg03264133 chr6:25882463 NA -0.67 -14.93 -0.51 1.83e-43 Intelligence (multi-trait analysis); BRCA cis rs6430585 0.583 rs61253125 chr2:136618178 T/C cg07169764 chr2:136633963 MCM6 1.28 28.78 0.75 1.99e-117 Corneal structure; BRCA cis rs7927771 1.000 rs35902101 chr11:47795169 C/T cg18512352 chr11:47633146 NA -0.34 -8.24 -0.31 9.79e-16 Subjective well-being; BRCA cis rs2576037 0.523 rs590923 chr18:44404259 G/C cg19077165 chr18:44547161 KATNAL2 -0.6 -13.42 -0.47 2.45e-36 Personality dimensions; BRCA cis rs911555 0.723 rs7149767 chr14:103863545 G/A cg12935359 chr14:103987150 CKB 0.62 14.43 0.5 4.64e-41 Intelligence (multi-trait analysis); BRCA cis rs1707322 0.721 rs4660314 chr1:46229885 T/C cg03146154 chr1:46216737 IPP 0.54 12.12 0.43 1.45e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs61931739 0.500 rs11053280 chr12:34559297 G/T cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg15662616 chr7:148823355 ZNF425;ZNF398 0.45 10.13 0.37 1.75e-22 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA trans rs9944715 1.000 rs6507693 chr18:43829137 G/A cg01718231 chr17:29326311 RNF135 -0.46 -9.26 -0.34 3.18e-19 Red cell distribution width;Mean corpuscular volume; BRCA cis rs12142240 0.698 rs67487250 chr1:46811333 T/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs7666738 0.830 rs7687958 chr4:99014495 T/C cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.48e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2832077 0.527 rs2738953 chr21:30238363 G/C cg08807101 chr21:30365312 RNF160 0.5 11.12 0.4 2.18e-26 Cognitive test performance; BRCA cis rs1707322 0.721 rs4330955 chr1:46217485 G/C cg06784218 chr1:46089804 CCDC17 0.51 12.17 0.43 8.34e-31 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs2727020 0.523 rs7948958 chr11:49506749 G/A cg15704280 chr7:45808275 SEPT13 0.74 15.07 0.51 3.94e-44 Coronary artery disease; BRCA trans rs7647973 0.593 rs59684465 chr3:49874246 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.39 7.99 0.3 6.22e-15 Menarche (age at onset); BRCA trans rs61931739 0.534 rs11053000 chr12:34079022 C/T cg26384229 chr12:38710491 ALG10B 0.67 14.17 0.49 7.99e-40 Morning vs. evening chronotype; BRCA trans rs2727020 0.704 rs2988340 chr11:49176057 C/T cg11707556 chr5:10655725 ANKRD33B -0.46 -10.97 -0.4 9.35e-26 Coronary artery disease; BRCA cis rs17376456 0.825 rs7715562 chr5:93222034 C/T cg21475434 chr5:93447410 FAM172A -0.69 -8.69 -0.33 3.01e-17 Diabetic retinopathy; BRCA cis rs9733 0.596 rs6587516 chr1:150623221 C/T cg04414720 chr1:150670196 GOLPH3L 0.35 7.84 0.3 1.88e-14 Tonsillectomy; BRCA cis rs3784262 0.669 rs4646554 chr15:58355437 A/G cg12031962 chr15:58353849 ALDH1A2 -0.39 -10.46 -0.38 9.33e-24 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7552404 0.731 rs17650138 chr1:76398887 C/T cg03433033 chr1:76189801 ACADM -0.69 -12.68 -0.45 4.97e-33 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs6089829 0.926 rs1060491 chr20:61665817 C/A cg17470723 chr8:74884337 TCEB1 -0.41 -8.53 -0.32 1.09e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 0.882 rs13099136 chr3:10031431 G/A cg16606324 chr3:10149918 C3orf24 0.49 9.81 0.36 2.97e-21 Alzheimer's disease; BRCA cis rs1011018 0.628 rs10268753 chr7:139419888 C/T cg03224163 chr7:139420300 HIPK2 -0.53 -8.85 -0.33 8.73e-18 Systolic blood pressure; BRCA trans rs9291683 0.595 rs35250962 chr4:10048271 C/T cg26043149 chr18:55253948 FECH 0.43 9.24 0.34 3.53e-19 Bone mineral density; BRCA cis rs2625529 0.775 rs2723342 chr15:72107699 G/C cg16672083 chr15:72433130 SENP8 -0.79 -15.65 -0.53 5.92e-47 Red blood cell count; BRCA trans rs6951245 0.507 rs11763865 chr7:1194274 G/A cg13565492 chr6:43139072 SRF -0.5 -8.47 -0.32 1.73e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6831352 1.000 rs6822348 chr4:100053894 A/T cg13256891 chr4:100009986 ADH5 0.47 9.03 0.34 2.09e-18 Alcohol dependence; BRCA cis rs13095912 0.785 rs4686682 chr3:185307402 C/T cg11274856 chr3:185301563 NA 0.54 13.1 0.46 6.59e-35 Systolic blood pressure; BRCA cis rs4268898 0.662 rs72793967 chr2:24422902 C/T cg06627628 chr2:24431161 ITSN2 -0.84 -15.45 -0.52 5.22e-46 Asthma; BRCA cis rs1580019 0.563 rs13244332 chr7:32537679 G/A cg06627557 chr7:32535165 LSM5;AVL9 1.11 32.35 0.79 9.94e-137 Cognitive ability; BRCA cis rs3768617 1.000 rs2027077 chr1:183073453 G/C ch.1.3577855R chr1:183094577 LAMC1 0.47 10.33 0.38 3.14e-23 Fuchs's corneal dystrophy; BRCA cis rs2991971 0.967 rs12133294 chr1:45988764 C/T cg15605315 chr1:45957053 TESK2 0.49 10.15 0.37 1.56e-22 High light scatter reticulocyte count; BRCA cis rs3784262 0.669 rs7180059 chr15:58288172 C/T cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.87 -0.36 1.75e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs7552404 0.691 rs61770550 chr1:76366966 C/T cg22875332 chr1:76189707 ACADM 0.65 11.79 0.42 3.61e-29 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs459571 0.959 rs2810491 chr9:136923331 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 0.76 14.45 0.5 3.6e-41 Platelet distribution width; BRCA cis rs60843830 1.000 rs55753056 chr2:243929 G/A cg25945732 chr2:264204 ACP1;SH3YL1 0.8 19.43 0.61 2.03e-66 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9443645 0.901 rs9361451 chr6:79555055 T/C cg18132916 chr6:79620363 NA -0.5 -11.39 -0.41 1.68e-27 Intelligence (multi-trait analysis); BRCA cis rs220324 0.688 rs4283513 chr21:43566409 G/T cg09727148 chr21:43560719 UMODL1 0.44 7.92 0.3 1.09e-14 Idiopathic osteonecrosis of the femoral head; BRCA cis rs769267 0.896 rs10410664 chr19:19556651 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.28e-18 Tonsillectomy; BRCA cis rs9649213 0.574 rs34830366 chr7:97899535 G/T cg24562669 chr7:97807699 LMTK2 0.46 11.8 0.42 3.21e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs262150 0.659 rs2657340 chr7:158796968 C/T cg23096020 chr7:158799433 NA 0.37 8.98 0.33 2.94e-18 Facial morphology (factor 20); BRCA cis rs4481887 1.000 rs4916128 chr1:248466706 G/A cg13385794 chr1:248469461 NA 0.28 7.81 0.3 2.28e-14 Common traits (Other); BRCA cis rs922182 0.904 rs9972469 chr15:64283793 C/A cg24729988 chr15:64271149 DAPK2 0.44 9.54 0.35 3.05e-20 Blood protein levels; BRCA cis rs11083475 0.599 rs7250443 chr19:39267345 T/C cg07905965 chr19:39260460 NA 0.47 10.5 0.38 6.86e-24 Heart rate; BRCA cis rs11711311 1.000 rs9863050 chr3:113508888 C/G cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.46 -10.1 -0.37 2.42e-22 IgG glycosylation; BRCA cis rs9287719 0.614 rs10929678 chr2:10723095 T/C cg00105475 chr2:10696890 NA 0.47 10.42 0.38 1.35e-23 Prostate cancer; BRCA cis rs739401 0.611 rs417957 chr11:3046231 A/G cg25174290 chr11:3078921 CARS 0.47 14.29 0.49 2.19e-40 Longevity; BRCA cis rs6973256 0.897 rs10266435 chr7:133346081 C/T cg07491979 chr7:133331646 EXOC4 -0.39 -8.55 -0.32 8.74e-17 Intelligence (multi-trait analysis); BRCA trans rs9388451 0.874 rs13209968 chr6:126089285 G/C cg05039488 chr6:79577232 IRAK1BP1 -0.52 -12.15 -0.43 1.0500000000000001e-30 Brugada syndrome; BRCA cis rs17401966 0.838 rs10864449 chr1:10296922 A/T cg03954927 chr1:10346856 KIF1B 0.44 13.94 0.48 9.07e-39 Hepatocellular carcinoma; BRCA cis rs6964587 1.000 rs55745934 chr7:91670998 T/C cg17063962 chr7:91808500 NA 0.54 12.26 0.44 3.55e-31 Breast cancer; BRCA cis rs651907 0.535 rs11707250 chr3:101509371 A/T cg03837452 chr3:101395095 ZBTB11;LOC100009676 -0.51 -13.1 -0.46 6.43e-35 Colorectal cancer; BRCA cis rs3784262 0.565 rs12914414 chr15:58318757 T/C cg12031962 chr15:58353849 ALDH1A2 -0.36 -9.51 -0.35 3.82e-20 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA cis rs4700695 0.719 rs27082 chr5:65436152 A/C cg21114390 chr5:65439923 SFRS12 -0.54 -10.13 -0.37 1.9e-22 Facial morphology (factor 19); BRCA cis rs12477438 0.798 rs6759354 chr2:99632195 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.68 -14.89 -0.51 2.92e-43 Chronic sinus infection; BRCA cis rs3733585 0.624 rs58130873 chr4:9972081 T/C cg11266682 chr4:10021025 SLC2A9 -0.38 -9.87 -0.36 1.73e-21 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.830 rs4699598 chr4:99019158 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.47 0.57 3.9e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs2243480 1.000 rs160648 chr7:65543384 C/A cg18252515 chr7:66147081 NA -0.99 -13.97 -0.48 6.87e-39 Diabetic kidney disease; BRCA cis rs9443645 0.527 rs1413968 chr6:79791042 A/G cg18132916 chr6:79620363 NA -0.4 -8.42 -0.32 2.47e-16 Intelligence (multi-trait analysis); BRCA trans rs6598955 0.671 rs8564 chr1:26605069 T/C cg07461501 chr17:79650226 HGS;ARL16 -0.67 -15.49 -0.52 3.38e-46 Obesity-related traits; BRCA cis rs9470366 0.848 rs66761782 chr6:36636080 T/C cg08179530 chr6:36648295 CDKN1A 0.55 10.76 0.39 6.32e-25 QRS duration; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg10819733 chr22:24237672 NA 0.31 8.2 0.31 1.36e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs796364 0.806 rs6435041 chr2:200867144 A/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.73 11.14 0.4 1.83e-26 Schizophrenia; BRCA cis rs514406 0.679 rs545719 chr1:53304922 T/C cg01802117 chr1:53393560 SCP2 -0.39 -8.57 -0.32 7.79e-17 Monocyte count; BRCA cis rs9287719 0.967 rs759403 chr2:10729897 C/T cg02196655 chr2:10830764 NOL10 -0.3 -8.09 -0.3 3.04e-15 Prostate cancer; BRCA cis rs12142240 0.698 rs72886911 chr1:46814352 G/A cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs8070624 0.502 rs12951376 chr17:17752809 C/T cg04398451 chr17:18023971 MYO15A -0.57 -11.37 -0.41 1.99e-27 Total body bone mineral density; BRCA cis rs7949030 0.653 rs17773169 chr11:62318530 G/T cg13298116 chr11:62369859 EML3;MTA2 0.54 13.5 0.47 9.84e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7811142 0.830 rs11761426 chr7:99956893 A/T cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.12 20.35 0.63 2.32e-71 Platelet count; BRCA cis rs875971 0.862 rs10261398 chr7:65750164 A/G cg18876405 chr7:65276391 NA -0.51 -11.54 -0.42 3.95e-28 Aortic root size; BRCA cis rs12586317 0.513 rs11156871 chr14:35481196 G/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.25 -0.38 6.29e-23 Psoriasis; BRCA cis rs220324 0.618 rs9975331 chr21:43559892 T/C cg09727148 chr21:43560719 UMODL1 0.49 8.39 0.32 3.01e-16 Idiopathic osteonecrosis of the femoral head; BRCA cis rs6942756 0.531 rs7811141 chr7:128908273 C/G cg02491457 chr7:128862824 NA 0.44 9.21 0.34 4.5e-19 White matter hyperintensity burden; BRCA cis rs4774830 0.744 rs12438427 chr15:56295062 A/T cg24530489 chr15:56299380 NA 0.82 9.61 0.36 1.68e-20 Delta-5 desaturase activity; BRCA cis rs13064411 0.696 rs869342 chr3:113226330 C/T cg18753928 chr3:113234510 CCDC52 -0.58 -12.22 -0.44 5.01e-31 Response to simvastatin treatment (PCSK9 protein level change); BRCA cis rs6964587 0.692 rs2158138 chr7:91700879 A/G cg17063962 chr7:91808500 NA 0.56 12.77 0.45 2.03e-33 Breast cancer; BRCA cis rs7447593 0.518 rs4074995 chr5:176797343 C/T cg05207973 chr5:176823642 SLC34A1 0.35 7.84 0.3 1.89e-14 Urinary electrolytes (magnesium/calcium ratio); BRCA cis rs2197308 0.765 rs12230545 chr12:37927114 C/T cg13010199 chr12:38710504 ALG10B -0.4 -8.63 -0.32 5.04e-17 Morning vs. evening chronotype; BRCA trans rs12599106 0.648 rs12447240 chr16:34928236 C/T cg05064044 chr6:292385 DUSP22 0.63 13.0 0.46 1.82e-34 Menopause (age at onset); BRCA cis rs290268 0.585 rs290992 chr9:93561309 C/T cg02608019 chr9:93564028 SYK -0.43 -9.09 -0.34 1.27e-18 Platelet count; BRCA cis rs7927771 0.965 rs56400411 chr11:47586376 T/G cg18512352 chr11:47633146 NA -0.37 -9.1 -0.34 1.1e-18 Subjective well-being; BRCA cis rs2463822 0.844 rs72923263 chr11:62161170 C/G cg06239285 chr11:62104954 ASRGL1 -0.67 -9.12 -0.34 9.83e-19 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs2197308 0.610 rs10880837 chr12:37864924 C/T cg13010199 chr12:38710504 ALG10B 0.45 8.92 0.33 4.88e-18 Morning vs. evening chronotype; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg18446336 chr7:2847575 GNA12 -0.36 -8.04 -0.3 4.51e-15 Height; BRCA cis rs4862750 0.872 rs7671914 chr4:187878165 A/G cg22105103 chr4:187893119 NA 0.42 13.29 0.47 9.52e-36 Lobe attachment (rater-scored or self-reported); BRCA cis rs9910055 0.529 rs190144 chr17:42164584 A/G cg19774624 chr17:42201019 HDAC5 0.43 10.44 0.38 1.12e-23 Total body bone mineral density; BRCA trans rs7824557 0.527 rs2409756 chr8:11242025 A/C cg15556689 chr8:8085844 FLJ10661 -0.3 -7.86 -0.3 1.65e-14 Retinal vascular caliber; BRCA cis rs1874326 0.524 rs6947999 chr7:138109868 A/G cg18008034 chr7:138118925 NA -0.45 -9.28 -0.34 2.54e-19 Quantitative traits; BRCA cis rs17376456 0.825 rs55947981 chr5:93278104 G/T cg25358565 chr5:93447407 FAM172A 1.21 18.8 0.6 4.09e-63 Diabetic retinopathy; BRCA cis rs11098499 0.774 rs73842616 chr4:120290683 G/A cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs12497850 0.931 rs9311430 chr3:48845251 C/T cg06212747 chr3:49208901 KLHDC8B 0.47 9.62 0.36 1.51e-20 Parkinson's disease; BRCA trans rs11098499 0.863 rs9997631 chr4:120469995 C/G cg25214090 chr10:38739885 LOC399744 0.51 11.5 0.41 5.81e-28 Corneal astigmatism; BRCA cis rs7618915 0.547 rs62253700 chr3:52625019 T/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.61 -0.45 9.81e-33 Bipolar disorder; BRCA cis rs6450176 1.000 rs6450175 chr5:53297824 C/T ch.5.1024479R chr5:53302184 ARL15 -0.63 -15.18 -0.51 1.2e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs1355223 0.506 rs12294339 chr11:34860199 C/T cg11058730 chr11:34937778 PDHX;APIP -0.46 -8.92 -0.33 4.96e-18 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7772486 0.686 rs857882 chr6:145969716 T/G cg05347473 chr6:146136440 FBXO30 -0.42 -8.36 -0.31 3.91e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs2070488 0.775 rs6780349 chr3:38555178 C/T cg24069376 chr3:38537580 EXOG -0.3 -8.62 -0.32 5.19e-17 Electrocardiographic conduction measures; BRCA cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg06544989 chr22:39130855 UNC84B 0.35 8.35 0.31 4.14e-16 Menopause (age at onset); BRCA cis rs9300255 0.722 rs10773008 chr12:123800820 A/G cg00376283 chr12:123451042 ABCB9 0.49 11.26 0.41 5.96e-27 Neutrophil percentage of white cells; BRCA cis rs9815354 0.812 rs17284472 chr3:41996304 A/G cg03022575 chr3:42003672 ULK4 -0.61 -8.96 -0.33 3.6e-18 Pulse pressure;Diastolic blood pressure; BRCA cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg16405210 chr4:1374714 KIAA1530 -0.93 -22.1 -0.66 7.49e-81 Longevity; BRCA cis rs17270561 0.609 rs7754296 chr6:25744878 A/G cg16482183 chr6:26056742 HIST1H1C 0.45 8.72 0.33 2.48e-17 Iron status biomarkers; BRCA cis rs4727027 0.866 rs3735311 chr7:148877737 T/C cg15662616 chr7:148823355 ZNF425;ZNF398 0.4 9.33 0.35 1.73e-19 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs6684514 0.922 rs12037778 chr1:156284864 A/G cg16558208 chr1:156270281 VHLL 0.36 8.45 0.32 1.99e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2549003 0.811 rs10072700 chr5:131816903 A/C cg02551604 chr5:131831745 NA -0.36 -9.81 -0.36 2.95e-21 Asthma (sex interaction); BRCA cis rs8072100 0.817 rs12449647 chr17:45548958 C/A cg25173405 chr17:45401733 C17orf57 -0.53 -11.32 -0.41 3.23e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs495337 0.965 rs6122848 chr20:48546557 A/G cg17835207 chr20:48524531 SPATA2 -0.69 -16.79 -0.55 1.13e-52 Psoriasis; BRCA cis rs7589728 0.563 rs78685993 chr2:88447026 T/C cg07952391 chr2:88470173 THNSL2 0.68 9.27 0.34 2.76e-19 Plasma clusterin levels; BRCA cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg13319975 chr6:146136371 FBXO30 0.34 7.9 0.3 1.22e-14 Lobe attachment (rater-scored or self-reported); BRCA trans rs61931739 0.517 rs7139189 chr12:34319757 T/C cg26384229 chr12:38710491 ALG10B 0.46 10.49 0.38 7.34e-24 Morning vs. evening chronotype; BRCA cis rs7258465 1.000 rs8109573 chr19:18617151 G/T cg01065977 chr19:18549689 ISYNA1 -0.29 -8.52 -0.32 1.1e-16 Breast cancer; BRCA cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg20573242 chr4:122745356 CCNA2 0.49 10.92 0.4 1.43e-25 Type 2 diabetes; BRCA cis rs11051970 0.679 rs2931554 chr12:32556162 G/A cg24626660 chr12:32551988 NA 0.32 9.43 0.35 7.74e-20 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2836974 0.966 rs7283420 chr21:40666865 T/C cg17971929 chr21:40555470 PSMG1 0.74 15.72 0.53 2.49e-47 Cognitive function; BRCA cis rs2304069 0.913 rs3812009 chr5:149380159 G/C cg22760475 chr5:149380129 HMGXB3;TIGD6 0.83 16.68 0.55 4.06e-52 HIV-1 control; BRCA cis rs523522 0.962 rs11065154 chr12:120971417 T/C cg27279351 chr12:120934652 DYNLL1 0.57 13.34 0.47 5.7e-36 High light scatter reticulocyte count; BRCA cis rs72772090 0.908 rs72772091 chr5:96040122 C/A cg17330273 chr5:96107758 CAST;ERAP1 -0.51 -11.29 -0.41 4.54e-27 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs6570726 0.693 rs450921 chr6:145864260 C/T cg05347473 chr6:146136440 FBXO30 0.43 8.44 0.32 2.08e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.683 rs55868006 chr8:58135703 C/T cg08219700 chr8:58056026 NA 0.45 8.34 0.31 4.68e-16 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg25036284 chr2:26402008 FAM59B -0.7 -11.33 -0.41 3.16e-27 Gut microbiome composition (summer); BRCA trans rs6089829 0.925 rs11086152 chr20:61664656 T/C cg15934090 chr1:100435551 SLC35A3 0.36 8.49 0.32 1.46e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs1994135 0.669 rs2121831 chr12:33697674 G/A cg06521331 chr12:34319734 NA -0.48 -8.66 -0.32 3.96e-17 Resting heart rate; BRCA cis rs10191773 0.535 rs56048537 chr2:113078467 G/T cg07905836 chr2:113190072 RGPD8;RGPD5 0.57 8.23 0.31 1.07e-15 Yeast infection; BRCA cis rs60843830 0.661 rs6755432 chr2:106692 T/C cg00108164 chr2:264199 ACP1;SH3YL1 0.49 8.72 0.33 2.46e-17 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2836974 0.568 rs428602 chr21:40547004 A/G cg11644478 chr21:40555479 PSMG1 0.65 14.42 0.5 5.28e-41 Cognitive function; BRCA trans rs561341 1.000 rs4795670 chr17:30244839 T/C cg27661571 chr11:113659931 NA -0.53 -8.93 -0.33 4.64e-18 Hip circumference adjusted for BMI; BRCA cis rs4888262 0.526 rs7193423 chr16:74626340 A/C cg01733217 chr16:74700730 RFWD3 0.74 19.11 0.6 9.49e-65 Testicular germ cell tumor; BRCA cis rs3812049 0.737 rs790154 chr5:127501235 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.56 10.45 0.38 1.06e-23 Lymphocyte counts;Red cell distribution width; BRCA cis rs9381040 0.599 rs2057001 chr6:41022947 A/G cg25110423 chr6:41068646 NFYA;LOC221442 -0.41 -9.83 -0.36 2.41e-21 Alzheimer's disease (late onset); BRCA cis rs1865760 1.000 rs6938233 chr6:25914077 C/T cg16482183 chr6:26056742 HIST1H1C 0.54 11.29 0.41 4.53e-27 Height; BRCA cis rs4853012 0.838 rs4429500 chr2:74345336 A/G cg20891558 chr2:74357851 NA 0.48 11.87 0.42 1.73e-29 Gestational age at birth (maternal effect); BRCA cis rs8017423 0.967 rs11624725 chr14:90713609 G/T cg04374321 chr14:90722782 PSMC1 -0.74 -20.17 -0.62 2.34e-70 Mortality in heart failure; BRCA cis rs35995292 0.534 rs11980627 chr7:38907533 T/C cg19327137 chr7:38886074 VPS41 0.4 13.57 0.47 5.07e-37 Subjective well-being (multi-trait analysis); BRCA cis rs965469 1.000 rs6051753 chr20:3315513 G/A cg25506879 chr20:3388711 C20orf194 -0.56 -10.89 -0.4 1.93e-25 IFN-related cytopenia; BRCA cis rs6964587 1.000 rs411 chr7:91557758 C/G cg17063962 chr7:91808500 NA -0.52 -11.91 -0.43 1.17e-29 Breast cancer; BRCA cis rs12711979 0.740 rs6715434 chr2:3820862 T/G cg17052675 chr2:3827356 NA -0.48 -14.31 -0.49 1.8e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs9649213 0.593 rs6465682 chr7:98016417 C/A cg24562669 chr7:97807699 LMTK2 0.44 11.79 0.42 3.53e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7178375 0.607 rs7171212 chr15:31207711 C/T cg03767031 chr15:31195708 MTMR15 0.61 8.11 0.31 2.64e-15 Hypertriglyceridemia; BRCA trans rs11098499 0.644 rs2389880 chr4:120559870 T/A cg25214090 chr10:38739885 LOC399744 0.44 9.93 0.37 1.08e-21 Corneal astigmatism; BRCA cis rs6089584 0.830 rs4925331 chr20:60580174 T/C cg12751644 chr20:60527061 NA -0.33 -7.91 -0.3 1.1e-14 Body mass index; BRCA cis rs9291683 0.546 rs12504565 chr4:10045145 G/A cg00071950 chr4:10020882 SLC2A9 0.55 13.2 0.46 2.4e-35 Bone mineral density; BRCA trans rs17685 0.753 rs11982200 chr7:75714883 T/C cg19862616 chr7:65841803 NCRNA00174 0.86 28.7 0.75 5.2e-117 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6782228 0.606 rs1697 chr3:128356852 C/T cg16766828 chr3:128327626 NA -0.43 -9.7 -0.36 7.92e-21 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs1167827 1.000 rs1167827 chr7:75163169 A/G cg16384552 chr7:74938386 SPDYE8P -0.51 -11.09 -0.4 2.94e-26 Body mass index;BMI (adjusted for smoking behaviour);BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs61931739 0.500 rs1843736 chr12:34012080 C/G cg13010199 chr12:38710504 ALG10B 0.47 9.03 0.34 2.04e-18 Morning vs. evening chronotype; BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg20607798 chr8:58055168 NA 0.58 9.27 0.34 2.73e-19 Developmental language disorder (linguistic errors); BRCA cis rs4555082 0.834 rs2735816 chr14:105721603 C/G cg10792982 chr14:105748885 BRF1 -0.46 -11.03 -0.4 4.9e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs9644630 0.965 rs10105097 chr8:19364883 A/C cg01280390 chr8:19363452 CSGALNACT1 -0.37 -8.52 -0.32 1.19e-16 Oropharynx cancer; BRCA cis rs8017423 0.647 rs4900037 chr14:90821478 A/G cg04374321 chr14:90722782 PSMC1 0.5 12.17 0.43 8.48e-31 Mortality in heart failure; BRCA cis rs6598955 0.950 rs6700455 chr1:26545864 T/C cg00852783 chr1:26633632 UBXN11 -0.49 -10.62 -0.39 2.31e-24 Obesity-related traits; BRCA cis rs9420 0.961 rs7116341 chr11:57481155 G/A cg19752551 chr11:57585705 CTNND1 -0.51 -12.49 -0.44 3.34e-32 Schizophrenia; BRCA cis rs6977660 0.943 rs10254261 chr7:19846001 A/G cg07541023 chr7:19748670 TWISTNB -0.4 -7.82 -0.3 2.21e-14 Thyroid stimulating hormone; BRCA cis rs10504229 1.000 rs55944282 chr8:58180821 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.5 -0.47 1.02e-36 Developmental language disorder (linguistic errors); BRCA cis rs9309711 0.623 rs4641971 chr2:3481857 A/C cg08493051 chr2:3487164 NA 0.42 9.0 0.34 2.57e-18 Neurofibrillary tangles; BRCA cis rs2797160 1.000 rs6933302 chr6:126016951 T/C cg05901451 chr6:126070800 HEY2 0.39 9.6 0.36 1.76e-20 Endometrial cancer; BRCA cis rs4819052 0.851 rs7281263 chr21:46695606 T/C cg02159808 chr21:46707872 POFUT2;LOC642852 0.5 9.45 0.35 6.12e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg12573674 chr2:1569213 NA -0.45 -8.63 -0.32 4.93e-17 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs2739330 0.761 rs5760176 chr22:24402321 A/G cg11905131 chr22:24372483 LOC391322 0.54 12.01 0.43 4.04e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs7615952 0.576 rs4646759 chr3:125822946 G/C cg04553112 chr3:125709451 NA -0.55 -8.34 -0.31 4.41e-16 Blood pressure (smoking interaction); BRCA cis rs72781680 0.898 rs72780121 chr2:23995918 T/C cg20701182 chr2:24300061 SF3B14 0.55 8.51 0.32 1.21e-16 Lymphocyte counts; BRCA trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg17830980 chr10:43048298 ZNF37B -0.56 -13.87 -0.48 1.9e-38 Extrinsic epigenetic age acceleration; BRCA cis rs6951245 0.529 rs10262070 chr7:1141738 C/T cg03188948 chr7:1209495 NA 0.68 11.26 0.41 5.97e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs2486288 0.656 rs12910009 chr15:45572408 A/G cg15395560 chr15:45543142 SLC28A2 0.29 7.93 0.3 9.86e-15 Glomerular filtration rate; BRCA cis rs4073582 0.595 rs1115508 chr11:65923149 A/G cg14036092 chr11:66035641 RAB1B 0.39 10.73 0.39 7.91e-25 Gout; BRCA cis rs7659604 0.518 rs17452156 chr4:122733623 T/C cg19748678 chr4:122722346 EXOSC9 0.74 15.94 0.53 2.16e-48 Type 2 diabetes; BRCA cis rs2404602 0.716 rs17461634 chr15:76764107 G/A cg23625390 chr15:77176239 SCAPER 0.4 9.37 0.35 1.24e-19 Blood metabolite levels; BRCA cis rs1008375 1.000 rs4698641 chr4:17642630 C/T cg16339924 chr4:17578868 LAP3 0.62 15.4 0.52 9.27e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs73242632 1.000 rs56798906 chr4:57875725 A/G cg20415529 chr4:57845134 POLR2B;C4orf14 0.69 8.27 0.31 8.02e-16 Congenital heart disease (maternal effect); BRCA cis rs7659604 0.537 rs6823818 chr4:122731699 G/C cg06713675 chr4:122721982 EXOSC9 -0.54 -12.38 -0.44 1.06e-31 Type 2 diabetes; BRCA cis rs6429082 0.715 rs9793740 chr1:235595590 T/C cg26050004 chr1:235667680 B3GALNT2 -0.54 -12.82 -0.45 1.22e-33 Adiposity; BRCA cis rs4363385 0.597 rs55667413 chr1:152976849 G/T cg25856811 chr1:152973957 SPRR3 -0.34 -9.08 -0.34 1.31e-18 Inflammatory skin disease; BRCA cis rs7772486 0.622 rs1292333 chr6:145982344 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -16.84 -0.55 6e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs4631830 0.720 rs2012677 chr10:51504797 T/A cg20129853 chr10:51489980 NA -0.32 -8.54 -0.32 9.98e-17 Prostate-specific antigen levels; BRCA cis rs6424115 0.830 rs2502999 chr1:24198321 A/G cg15997130 chr1:24165203 NA 0.44 11.49 0.41 6.91e-28 Immature fraction of reticulocytes; BRCA cis rs738321 0.790 rs4820317 chr22:38543287 T/C cg25457927 chr22:38595422 NA -0.33 -11.52 -0.41 4.89e-28 Breast cancer; BRCA cis rs9291683 0.595 rs3733585 chr4:10036339 A/G cg02734326 chr4:10020555 SLC2A9 0.39 8.48 0.32 1.61e-16 Bone mineral density; BRCA cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.88 -0.3 1.43e-14 Electroencephalogram traits; BRCA cis rs6066825 0.644 rs1040559 chr20:47314445 A/G cg18078177 chr20:47281410 PREX1 0.42 10.27 0.38 5.11e-23 Colorectal cancer; BRCA cis rs10504229 0.683 rs7822631 chr8:58130916 C/G cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs2404602 0.716 rs12437627 chr15:76845050 T/C cg26408565 chr15:76604113 ETFA -0.46 -9.82 -0.36 2.61e-21 Blood metabolite levels; BRCA cis rs28735056 1.000 rs4798923 chr18:77629373 G/A cg20368463 chr18:77673604 PQLC1 -0.34 -8.19 -0.31 1.41e-15 Schizophrenia; BRCA trans rs561341 0.883 rs1034627 chr17:30219569 C/T cg20587970 chr11:113659929 NA -0.64 -11.06 -0.4 3.94e-26 Hip circumference adjusted for BMI; BRCA cis rs6089829 0.962 rs6089825 chr20:61668447 C/T cg03213289 chr20:61660250 NA 0.62 16.32 0.54 2.77e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs965469 1.000 rs2281503 chr20:3263636 G/A cg25506879 chr20:3388711 C20orf194 -0.51 -10.2 -0.37 9.47e-23 IFN-related cytopenia; BRCA cis rs34779708 0.931 rs7079205 chr10:35324619 C/T cg03585969 chr10:35415529 CREM 0.5 10.23 0.38 7.21e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs13082711 0.595 rs13075389 chr3:27339586 C/T cg02860705 chr3:27208620 NA 0.76 13.96 0.48 7.59e-39 Systolic blood pressure;Diastolic blood pressure;Blood pressure; BRCA cis rs4713118 0.869 rs7773070 chr6:27728827 T/C cg26587870 chr6:27730563 NA -0.41 -8.71 -0.33 2.57e-17 Parkinson's disease; BRCA cis rs3091242 0.900 rs669063 chr1:25721154 A/G cg02931644 chr1:25747376 RHCE 0.47 13.1 0.46 6.75e-35 Erythrocyte sedimentation rate; BRCA cis rs12458462 0.859 rs35493271 chr18:77448793 G/T cg11879182 chr18:77439856 CTDP1 0.65 13.92 0.48 1.21e-38 Monocyte count; BRCA cis rs3806843 0.735 rs6849 chr5:140086191 G/T cg11822812 chr5:140052017 DND1 -0.3 -8.23 -0.31 1.07e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg20644253 chr19:19431407 KIAA0892;SF4 0.58 11.7 0.42 8.69e-29 Tonsillectomy; BRCA trans rs7618501 1.000 rs7372725 chr3:49790544 C/A cg21659725 chr3:3221576 CRBN -0.72 -21.74 -0.65 6.94e-79 Intelligence (multi-trait analysis); BRCA cis rs7246657 0.722 rs10403173 chr19:38078680 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.16 0.34 7.24e-19 Coronary artery calcification; BRCA cis rs1862618 0.853 rs863840 chr5:56128999 C/G cg22800045 chr5:56110881 MAP3K1 0.6 10.81 0.39 4.01e-25 Initial pursuit acceleration; BRCA cis rs11583043 0.874 rs41312668 chr1:101443582 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 0.4 8.02 0.3 4.99e-15 Ulcerative colitis;Inflammatory bowel disease; BRCA cis rs7552404 1.000 rs12123977 chr1:76209754 A/G cg22875332 chr1:76189707 ACADM -0.68 -14.0 -0.48 4.91e-39 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12541635 1.000 rs1896919 chr8:107090357 C/G cg10147462 chr8:107024639 NA -0.3 -8.29 -0.31 6.64e-16 Age of smoking initiation; BRCA cis rs2153535 0.540 rs9378557 chr6:8517381 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.65 0.39 1.73e-24 Motion sickness; BRCA cis rs4363385 0.693 rs4845331 chr1:152982623 A/G cg21543102 chr1:152974771 SPRR3 -0.29 -8.36 -0.31 3.82e-16 Inflammatory skin disease; BRCA cis rs9443645 0.869 rs1507154 chr6:79503700 C/T cg05283184 chr6:79620031 NA -0.45 -11.41 -0.41 1.4e-27 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.500 rs11053282 chr12:34561151 T/C cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg26944245 chr16:421049 TMEM8A;MRPL28 0.41 9.01 0.34 2.29e-18 Bone mineral density (spine);Bone mineral density; BRCA cis rs495337 0.699 rs6020075 chr20:48448695 A/G cg17835207 chr20:48524531 SPATA2 0.49 10.82 0.39 3.59e-25 Psoriasis; BRCA trans rs66887589 0.592 rs11731571 chr4:120221185 G/A cg25214090 chr10:38739885 LOC399744 0.35 8.2 0.31 1.36e-15 Diastolic blood pressure; BRCA cis rs1008375 0.863 rs2058336 chr4:17608299 T/C cg15017067 chr4:17643749 FAM184B 0.28 8.4 0.32 2.91e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9359856 0.510 rs6937789 chr6:90468775 C/G cg13799429 chr6:90582589 CASP8AP2 0.7 10.57 0.39 3.41e-24 Bipolar disorder; BRCA cis rs4665809 0.941 rs7602922 chr2:26265782 C/T cg22920501 chr2:26401640 FAM59B -0.81 -13.17 -0.46 3.22e-35 Gut microbiome composition (summer); BRCA trans rs6076960 0.652 rs3852945 chr20:6254118 T/C cg21095983 chr6:86352623 SYNCRIP 0.35 8.2 0.31 1.36e-15 Smooth-surface caries; BRCA cis rs2688608 0.592 rs10762563 chr10:75524802 C/A cg23231163 chr10:75533350 FUT11 -0.34 -8.98 -0.33 2.92e-18 Inflammatory bowel disease; BRCA cis rs7927592 0.956 rs10896334 chr11:68281494 C/T cg20283391 chr11:68216788 NA -0.44 -8.6 -0.32 6.13e-17 Total body bone mineral density; BRCA cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg01181863 chr3:195395398 SDHAP2 0.49 9.84 0.36 2.36e-21 Bronchopulmonary dysplasia; BRCA cis rs6598163 0.712 rs10751695 chr12:132291061 A/C cg04876069 chr12:132293656 NA -0.45 -9.77 -0.36 4.04e-21 Migraine; BRCA cis rs2120019 0.938 rs2289582 chr15:75310394 T/C cg17294928 chr15:75287854 SCAMP5 -0.75 -16.77 -0.55 1.44e-52 Blood trace element (Zn levels); BRCA cis rs1595825 0.945 rs76510735 chr2:198823095 G/A cg19156104 chr2:198669113 PLCL1 -0.44 -8.13 -0.31 2.26e-15 Ulcerative colitis; BRCA cis rs875971 0.929 rs12673810 chr7:65923853 T/A cg11764359 chr7:65958608 NA 0.8 19.33 0.61 6.8e-66 Aortic root size; BRCA cis rs1865760 0.827 rs9295681 chr6:25944117 T/G cg16482183 chr6:26056742 HIST1H1C 0.49 10.2 0.37 1.01e-22 Height; BRCA trans rs1973993 0.537 rs1988854 chr1:96989786 A/G cg10631902 chr5:14652156 NA -0.39 -9.82 -0.36 2.62e-21 Weight; BRCA cis rs854572 0.600 rs705382 chr7:94955221 C/G cg17330251 chr7:94953956 PON1 -0.45 -10.29 -0.38 4.31e-23 Paraoxonase activity; BRCA cis rs4555082 0.874 rs760270 chr14:105737785 A/G cg27165867 chr14:105738592 BRF1 -0.36 -8.37 -0.31 3.53e-16 Mean platelet volume;Platelet distribution width; BRCA cis rs13191362 0.507 rs2803051 chr6:163034979 G/A cg06582575 chr6:163149167 PACRG;PARK2 -0.46 -8.84 -0.33 9.17e-18 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs1325195 0.879 rs2791940 chr1:179115485 C/T cg11624085 chr17:8464688 MYH10 0.26 7.86 0.3 1.65e-14 IgE grass sensitization; BRCA cis rs35110281 0.782 rs2246602 chr21:45064296 C/A cg01579765 chr21:45077557 HSF2BP -0.45 -12.19 -0.43 7.28e-31 Mean corpuscular volume; BRCA cis rs1401999 0.898 rs6443928 chr3:183729487 C/T cg20387954 chr3:183756860 HTR3D 0.47 10.7 0.39 1.09e-24 Anterior chamber depth; BRCA cis rs12701220 0.901 rs12701710 chr7:1090396 A/G cg26769984 chr7:1090371 C7orf50 -0.69 -13.56 -0.47 5.41e-37 Bronchopulmonary dysplasia; BRCA cis rs34779708 0.931 rs4934700 chr10:35310842 A/G cg03585969 chr10:35415529 CREM 0.56 11.59 0.42 2.46e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6545883 0.929 rs9679557 chr2:61709349 C/A cg15711740 chr2:61764176 XPO1 -0.55 -13.86 -0.48 2.21e-38 Tuberculosis; BRCA cis rs2836950 0.509 rs4816618 chr21:40599529 G/A cg11644478 chr21:40555479 PSMG1 -0.5 -10.67 -0.39 1.46e-24 Menarche (age at onset); BRCA trans rs2204008 0.777 rs114096617 chr12:38342557 A/C cg06521331 chr12:34319734 NA -0.47 -8.56 -0.32 8.19e-17 Bladder cancer; BRCA cis rs62064224 0.714 rs11653974 chr17:30635002 T/C cg25809561 chr17:30822961 MYO1D 0.4 9.56 0.35 2.4e-20 Schizophrenia; BRCA cis rs1707322 0.785 rs10890348 chr1:46242423 G/T cg06784218 chr1:46089804 CCDC17 0.5 11.9 0.43 1.24e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs514406 0.621 rs1930306 chr1:53195686 C/G cg16325326 chr1:53192061 ZYG11B -0.85 -22.92 -0.67 2.73e-85 Monocyte count; BRCA cis rs9660180 0.846 rs10907195 chr1:1713348 C/T cg27541892 chr1:1571801 CDK11B -0.35 -7.84 -0.3 1.85e-14 Body mass index; BRCA cis rs9473147 0.516 rs7754282 chr6:47502024 C/G cg12968598 chr6:47444699 CD2AP -0.44 -9.63 -0.36 1.4e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs61931739 0.534 rs4539411 chr12:34014807 T/C cg06521331 chr12:34319734 NA -0.59 -11.56 -0.42 3.37e-28 Morning vs. evening chronotype; BRCA cis rs858239 0.539 rs6955726 chr7:23186691 A/G cg23682824 chr7:23144976 KLHL7 0.41 10.64 0.39 1.8e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs7843479 0.965 rs2291317 chr8:21827162 C/T cg17168535 chr8:21777572 XPO7 0.46 10.38 0.38 1.9e-23 Mean corpuscular volume; BRCA cis rs7903847 0.642 rs10882913 chr10:99141845 C/T cg20016023 chr10:99160130 RRP12 -0.27 -8.62 -0.32 5.46e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs62458065 0.513 rs10268803 chr7:32547835 A/G cg20159608 chr7:32802032 NA -0.5 -9.61 -0.36 1.65e-20 Metabolite levels (HVA/MHPG ratio); BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg03188948 chr7:1209495 NA 0.44 8.13 0.31 2.29e-15 Longevity;Endometriosis; BRCA cis rs7829975 0.593 rs2921077 chr8:8304502 C/T cg08975724 chr8:8085496 FLJ10661 0.54 12.22 0.44 5.06e-31 Mood instability; BRCA cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg25358565 chr5:93447407 FAM172A 1.21 18.8 0.6 4.09e-63 Diabetic retinopathy; BRCA cis rs9287719 0.935 rs10803723 chr2:10722877 C/T cg00105475 chr2:10696890 NA 0.44 10.25 0.38 6.46e-23 Prostate cancer; BRCA cis rs1790761 0.520 rs7124513 chr11:67395714 C/T cg08355456 chr11:67383691 NA -0.42 -8.64 -0.32 4.46e-17 Mean corpuscular volume; BRCA trans rs6598955 0.671 rs12089149 chr1:26638500 C/A cg07461501 chr17:79650226 HGS;ARL16 -0.66 -15.46 -0.52 5.17e-46 Obesity-related traits; BRCA cis rs908922 0.676 rs569032 chr1:152508615 C/T cg20991723 chr1:152506922 NA 0.38 8.67 0.32 3.47e-17 Hair morphology; BRCA cis rs30380 0.632 rs26498 chr5:96138812 C/T cg16492584 chr5:96139282 ERAP1 0.46 10.92 0.4 1.44e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs1707322 0.752 rs28507722 chr1:46206540 A/G cg06784218 chr1:46089804 CCDC17 0.5 11.98 0.43 5.89e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs11976180 1.000 rs2951360 chr7:143757349 C/A cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.47 -8.65 -0.32 4.09e-17 Obesity-related traits; BRCA cis rs6450176 0.625 rs3776726 chr5:53290052 T/A ch.5.1024479R chr5:53302184 ARL15 -0.68 -15.17 -0.51 1.22e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs736408 0.609 rs13082960 chr3:52785168 A/C cg10802521 chr3:52805072 NEK4 -0.32 -8.2 -0.31 1.33e-15 Bipolar disorder; BRCA cis rs1451375 0.583 rs3807556 chr7:50610536 G/A cg18232548 chr7:50535776 DDC 0.44 9.08 0.34 1.39e-18 Malaria; BRCA cis rs6088580 0.634 rs6088488 chr20:32992631 T/C cg08999081 chr20:33150536 PIGU -0.47 -12.85 -0.45 9.11e-34 Glomerular filtration rate (creatinine); BRCA cis rs6089829 0.855 rs6062781 chr20:61667128 G/A cg08564027 chr20:61660810 NA 0.84 22.84 0.67 7.41e-85 Prostate cancer (SNP x SNP interaction); BRCA trans rs79976124 0.842 rs74881738 chr6:66621825 T/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.84 0.39 3.12e-25 Type 2 diabetes; BRCA cis rs2204008 0.774 rs4534658 chr12:38246783 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.78e-18 Bladder cancer; BRCA cis rs9467711 0.591 rs116201501 chr6:25999149 C/T cg21479132 chr6:26055353 NA 0.57 7.97 0.3 7.48e-15 Autism spectrum disorder or schizophrenia; BRCA cis rs1862618 0.853 rs1862619 chr5:56098256 T/A cg20203395 chr5:56204925 C5orf35 -0.49 -10.25 -0.38 6.14e-23 Initial pursuit acceleration; BRCA cis rs7829975 0.688 rs7817376 chr8:8380530 C/T cg14343924 chr8:8086146 FLJ10661 -0.4 -8.29 -0.31 6.8e-16 Mood instability; BRCA trans rs11098499 0.863 rs3775845 chr4:120432447 T/C cg25214090 chr10:38739885 LOC399744 0.56 12.26 0.44 3.41e-31 Corneal astigmatism; BRCA cis rs796364 1.000 rs281762 chr2:200799201 C/G cg25936922 chr2:200820526 C2orf60;C2orf47 0.79 13.28 0.46 1.06e-35 Schizophrenia; BRCA cis rs651907 0.557 rs2318090 chr3:101474933 A/G cg12386194 chr3:101231763 SENP7 0.41 8.77 0.33 1.63e-17 Colorectal cancer; BRCA cis rs10504229 0.639 rs67002486 chr8:58117218 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs6964587 1.000 rs2237568 chr7:91622676 G/A cg01689657 chr7:91764605 CYP51A1 0.22 8.22 0.31 1.17e-15 Breast cancer; BRCA cis rs11758351 0.587 rs16891456 chr6:26234127 T/C cg01420254 chr6:26195488 NA 0.55 8.52 0.32 1.1e-16 Gout;Renal underexcretion gout; BRCA cis rs514406 0.861 rs2065477 chr1:53250213 C/T cg16325326 chr1:53192061 ZYG11B 0.76 17.2 0.56 9.15e-55 Monocyte count; BRCA cis rs738322 0.935 rs133014 chr22:38571087 T/G cg25457927 chr22:38595422 NA -0.32 -11.87 -0.43 1.63e-29 Cutaneous nevi; BRCA cis rs9394841 0.667 rs9367112 chr6:41769920 T/C cg08135965 chr6:41755394 TOMM6 0.5 8.13 0.31 2.18e-15 Mean corpuscular hemoglobin;Red cell distribution width; BRCA cis rs7246967 0.673 rs73028776 chr19:22813740 A/C cg23217946 chr19:22817039 ZNF492 0.47 8.43 0.32 2.22e-16 Bronchopulmonary dysplasia; BRCA cis rs7914558 0.933 rs2066323 chr10:104871361 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.81 0.39 4.09e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs1368882 1.000 rs1368882 chr1:55107019 A/G cg01517571 chr1:55089959 ACOT11;FAM151A -0.42 -9.11 -0.34 1.09e-18 Non-substance related behavioral disinhibition; BRCA cis rs9733 0.596 rs6669369 chr1:150695892 C/T cg17724175 chr1:150552817 MCL1 0.25 8.14 0.31 2.07e-15 Tonsillectomy; BRCA cis rs2303759 0.918 rs1054770 chr19:49878115 G/A cg22307029 chr19:49891270 CCDC155 0.62 11.3 0.41 4.17e-27 Multiple sclerosis; BRCA cis rs7178424 0.774 rs7172145 chr15:62239697 C/T cg00456672 chr15:62358751 C2CD4A 0.41 9.94 0.37 9.45e-22 Height; BRCA cis rs9325144 0.600 rs10880934 chr12:38730455 C/T cg26384229 chr12:38710491 ALG10B -0.52 -12.42 -0.44 6.78e-32 Morning vs. evening chronotype; BRCA cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg21770322 chr7:97807741 LMTK2 0.43 11.49 0.41 6.49e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs208520 0.690 rs1738970 chr6:66809491 T/G cg07460842 chr6:66804631 NA -1.0 -19.98 -0.62 2.38e-69 Exhaled nitric oxide output; BRCA cis rs7319311 1.000 rs7319311 chr13:111030578 A/G cg05272587 chr13:111038400 COL4A2 0.34 7.85 0.3 1.8e-14 Bipolar disorder and schizophrenia; BRCA cis rs10782582 0.609 rs5745410 chr1:76314356 C/A cg03433033 chr1:76189801 ACADM -0.41 -8.35 -0.31 4.3e-16 Daytime sleep phenotypes; BRCA cis rs13191362 0.935 rs34063386 chr6:163041271 T/C cg14584255 chr6:163149320 PACRG;PARK2 0.6 9.7 0.36 7.48e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs868036 1.000 rs7168156 chr15:68102933 T/C cg08079166 chr15:68083412 MAP2K5 0.35 9.46 0.35 5.8e-20 Restless legs syndrome; BRCA cis rs6942756 1.000 rs7778277 chr7:128978805 C/T cg02491457 chr7:128862824 NA -0.71 -14.05 -0.49 3e-39 White matter hyperintensity burden; BRCA cis rs7493 1.000 rs2068604 chr7:95041542 G/T cg19678392 chr7:94953810 PON1 -0.42 -9.02 -0.34 2.22e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs10197940 0.545 rs2444267 chr2:152308611 T/G cg19508488 chr2:152266495 RIF1 0.37 8.08 0.3 3.16e-15 Lung cancer; BRCA cis rs7618915 0.570 rs4687633 chr3:52630548 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.61 -0.45 9.81e-33 Bipolar disorder; BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg04013093 chr6:42928303 GNMT -0.28 -8.79 -0.33 1.4e-17 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs798554 0.704 rs798513 chr7:2782493 C/T cg18446336 chr7:2847575 GNA12 -0.37 -8.62 -0.32 5.08e-17 Height; BRCA trans rs208520 0.690 rs1776365 chr6:66834474 G/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -20.82 -0.64 6.89e-74 Exhaled nitric oxide output; BRCA cis rs881375 0.967 rs1008382 chr9:123681255 C/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.53 0.32 1.06e-16 Rheumatoid arthritis; BRCA cis rs9325144 0.560 rs11182979 chr12:38642562 C/A cg26384229 chr12:38710491 ALG10B -0.54 -13.43 -0.47 2.18e-36 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs10076052 chr5:93317762 C/T cg25358565 chr5:93447407 FAM172A 1.19 18.82 0.6 3.54e-63 Diabetic retinopathy; BRCA trans rs2204008 0.687 rs2320523 chr12:38251397 T/C cg06521331 chr12:34319734 NA -0.51 -9.75 -0.36 4.86e-21 Bladder cancer; BRCA trans rs6952808 0.771 rs10275045 chr7:1920826 C/T cg04565464 chr8:145669602 NFKBIL2 0.4 9.68 0.36 8.96e-21 Bipolar disorder and schizophrenia; BRCA cis rs12142240 0.583 rs5013330 chr1:46815154 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs7772486 0.790 rs2265918 chr6:146219164 A/G cg13319975 chr6:146136371 FBXO30 -0.41 -9.28 -0.34 2.63e-19 Lobe attachment (rater-scored or self-reported); BRCA trans rs2727020 0.724 rs4109837 chr11:49372051 A/T cg15704280 chr7:45808275 SEPT13 -0.75 -15.36 -0.52 1.55e-45 Coronary artery disease; BRCA cis rs12995491 0.731 rs13019346 chr2:88509321 A/G cg04511125 chr2:88470314 THNSL2 -0.5 -10.42 -0.38 1.36e-23 Response to metformin (IC50); BRCA cis rs9311474 0.508 rs6786043 chr3:52604861 A/G cg10712668 chr3:52740153 GLT8D1;SPCS1 0.5 11.33 0.41 2.95e-27 Electroencephalogram traits; BRCA cis rs4332037 0.615 rs62435127 chr7:1884937 A/G cg12432903 chr7:1882776 MAD1L1 0.45 8.14 0.31 2.08e-15 Bipolar disorder; BRCA cis rs274567 0.602 rs272853 chr5:131688561 A/G cg24060327 chr5:131705240 SLC22A5 -0.57 -11.8 -0.42 3.39e-29 Blood metabolite levels; BRCA cis rs1707322 1.000 rs12403666 chr1:46431621 G/A cg03146154 chr1:46216737 IPP 0.46 10.07 0.37 3.14e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg18402987 chr7:1209562 NA 0.62 13.53 0.47 7.67e-37 Longevity;Endometriosis; BRCA cis rs11112613 0.775 rs61200462 chr12:105969271 G/A cg03607813 chr12:105948248 NA 0.58 9.73 0.36 5.87e-21 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs801193 1.000 rs4279493 chr7:66226620 C/T cg18876405 chr7:65276391 NA 0.62 15.18 0.51 1.09e-44 Aortic root size; BRCA cis rs11051970 0.879 rs2651362 chr12:32587851 G/C cg24626660 chr12:32551988 NA 0.29 8.36 0.31 4e-16 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs778371 0.874 rs1083522 chr2:233745521 C/T cg08000102 chr2:233561755 GIGYF2 -0.78 -17.3 -0.56 2.75e-55 Schizophrenia; BRCA cis rs4908768 0.520 rs6681362 chr1:8658527 T/G cg20416874 chr1:8611966 RERE -0.29 -8.2 -0.31 1.27e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs6088580 0.634 rs6059875 chr20:33086090 T/G cg08999081 chr20:33150536 PIGU 0.45 12.54 0.44 2.02e-32 Glomerular filtration rate (creatinine); BRCA cis rs1003719 1.000 rs2154536 chr21:38492147 G/C cg10648535 chr21:38446584 PIGP;TTC3 0.62 14.17 0.49 7.99e-40 Eye color traits; BRCA cis rs1878931 0.597 rs37814 chr16:3455247 C/T cg26668626 chr16:3451006 ZNF174;ZNF434 -0.59 -9.84 -0.36 2.38e-21 Body mass index (adult); BRCA cis rs9287719 0.967 rs4669593 chr2:10701908 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.99 -0.3 6.45e-15 Prostate cancer; BRCA cis rs7975161 1.000 rs7975161 chr12:104645405 C/T cg25273343 chr12:104657179 TXNRD1 0.51 11.02 0.4 5.73e-26 Toenail selenium levels; BRCA cis rs9942416 0.660 rs111937612 chr5:74979631 C/T cg19683494 chr5:74908142 NA 0.48 8.95 0.33 3.81e-18 Age-related disease endophenotypes; BRCA cis rs10752881 0.967 rs4652758 chr1:182975100 T/C ch.1.3577855R chr1:183094577 LAMC1 0.63 16.65 0.55 5.99e-52 Colorectal cancer; BRCA cis rs6752107 1.000 rs13391356 chr2:234170369 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.58 0.42 2.86e-28 Crohn's disease;Inflammatory bowel disease; BRCA cis rs4665809 0.590 rs7582341 chr2:26416301 A/G cg08067268 chr2:26466485 HADHB;HADHA -0.59 -10.38 -0.38 1.89e-23 Gut microbiome composition (summer); BRCA cis rs4253311 0.544 rs4253244 chr4:187153775 C/A cg24794857 chr4:187113578 CYP4V2 0.39 8.16 0.31 1.73e-15 Plasma renin activity levels;Circulating chromogranin peptide levels;Blood metabolite levels; BRCA cis rs7666738 0.791 rs6828752 chr4:99063382 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.82 0.3 2.22e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs7662114 chr4:99019985 A/G cg03676636 chr4:99064102 C4orf37 0.21 8.05 0.3 4.14e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7917772 0.582 rs7899004 chr10:104341435 C/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.46 -13.34 -0.47 5.46e-36 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9296404 1 rs9296404 chr6:42925803 T/C cg09436375 chr6:42928200 GNMT -0.3 -10.85 -0.39 2.84e-25 Plasma homocysteine levels (post-methionine load test); BRCA cis rs477895 0.838 rs11605738 chr11:64013406 G/A cg18225595 chr11:63971243 STIP1 0.5 8.7 0.33 2.79e-17 Mean platelet volume; BRCA cis rs6942756 0.744 rs2718088 chr7:128927020 C/A cg02491457 chr7:128862824 NA 0.56 11.72 0.42 7.37e-29 White matter hyperintensity burden; BRCA cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg12193833 chr17:30244370 NA -0.54 -8.66 -0.32 3.95e-17 Hip circumference adjusted for BMI; BRCA cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg02659138 chr7:134003124 SLC35B4 0.33 10.13 0.37 1.75e-22 Mean platelet volume; BRCA cis rs10504229 1.000 rs60231757 chr8:58169937 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.07e-21 Developmental language disorder (linguistic errors); BRCA cis rs780096 0.506 rs2950834 chr2:27627366 G/A cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.16 -0.34 6.76e-19 Total body bone mineral density; BRCA cis rs10504229 0.728 rs72650867 chr8:58154912 C/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs35110281 0.667 rs4818859 chr21:45117120 G/A cg01579765 chr21:45077557 HSF2BP -0.43 -11.59 -0.42 2.62e-28 Mean corpuscular volume; BRCA cis rs35146811 0.807 rs10228764 chr7:99608029 A/G cg13334819 chr7:99746414 C7orf59 -0.42 -9.92 -0.37 1.16e-21 Coronary artery disease; BRCA cis rs3771570 1.000 rs73020143 chr2:242261240 T/A cg21155796 chr2:242212141 HDLBP 0.6 9.38 0.35 1.09e-19 Prostate cancer; BRCA cis rs1371614 0.635 rs10175737 chr2:27139747 C/A cg00617064 chr2:27272375 NA 0.3 7.88 0.3 1.41e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs17376456 0.877 rs10055340 chr5:93317644 T/C cg25358565 chr5:93447407 FAM172A 1.14 18.39 0.59 6.32e-61 Diabetic retinopathy; BRCA cis rs9467773 0.620 rs2451731 chr6:26624822 A/C cg11502198 chr6:26597334 ABT1 0.56 11.95 0.43 7.45e-30 Intelligence (multi-trait analysis); BRCA cis rs34779708 0.868 rs2384352 chr10:35492832 A/G cg03585969 chr10:35415529 CREM 0.48 9.84 0.36 2.2e-21 Inflammatory bowel disease;Crohn's disease; BRCA cis rs148734725 1 rs148734725 chr3:49406708 G/A cg03060546 chr3:49711283 APEH -0.51 -10.46 -0.38 9.45e-24 Educational attainment (college completion); BRCA cis rs6540559 0.673 rs926346 chr1:209962204 A/T cg22029157 chr1:209979665 IRF6 0.55 11.24 0.41 6.82e-27 Cleft lip with or without cleft palate; BRCA cis rs6763687 0.765 rs4894799 chr3:171795540 G/A cg16233210 chr3:171778391 FNDC3B 0.36 8.05 0.3 3.95e-15 Red cell distribution width; BRCA cis rs35110281 0.782 rs1454650 chr21:45012353 C/T cg01579765 chr21:45077557 HSF2BP -0.44 -11.66 -0.42 1.29e-28 Mean corpuscular volume; BRCA cis rs473651 0.935 rs559579 chr2:239339501 G/C cg21699342 chr2:239360505 ASB1 0.5 11.52 0.41 5.08e-28 Multiple system atrophy; BRCA cis rs7666738 0.791 rs4440223 chr4:99044796 G/A cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 1.000 rs12540579 chr7:1882227 C/A cg04267008 chr7:1944627 MAD1L1 -0.59 -12.9 -0.45 5.18e-34 Bipolar disorder and schizophrenia; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.12 -0.31 2.37e-15 Total body bone mineral density; BRCA cis rs5750830 0.649 rs5757659 chr22:39812409 A/C cg05872129 chr22:39784769 NA -0.56 -11.75 -0.42 5.42e-29 Intelligence (multi-trait analysis); BRCA cis rs798554 0.679 rs1636250 chr7:2884433 T/C cg13628971 chr7:2884303 GNA12 0.57 11.91 0.43 1.11e-29 Height; BRCA cis rs7336332 0.569 rs7988412 chr13:28000282 C/T cg22138327 chr13:27999177 GTF3A 0.6 12.17 0.43 8.24e-31 Weight; BRCA cis rs997295 0.554 rs7180312 chr15:68105256 G/A cg08079166 chr15:68083412 MAP2K5 0.31 8.33 0.31 5.03e-16 Motion sickness; BRCA cis rs3849570 0.643 rs10779986 chr3:81970818 C/G cg07356753 chr3:81810745 GBE1 0.36 8.42 0.32 2.57e-16 Waist circumference;Body mass index; BRCA trans rs208520 0.690 rs7739253 chr6:66861052 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.28 -0.64 2.26e-76 Exhaled nitric oxide output; BRCA cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg10295955 chr4:187884368 NA 0.93 26.88 0.73 4.81e-107 Lobe attachment (rater-scored or self-reported); BRCA cis rs66569888 0.789 rs66826026 chr2:106732879 C/T cg23109721 chr2:106886537 NA -0.47 -8.47 -0.32 1.63e-16 Facial morphology (factor 23); BRCA cis rs6714710 0.627 rs6748124 chr2:98519014 T/C cg26665480 chr2:98280029 ACTR1B 0.57 13.39 0.47 3.3e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7572733 0.555 rs11903129 chr2:198918591 A/T cg00792783 chr2:198669748 PLCL1 0.39 8.81 0.33 1.14e-17 Dermatomyositis; BRCA cis rs2180341 0.961 rs7775493 chr6:127615000 C/A cg24812749 chr6:127587940 RNF146 0.88 20.63 0.63 7.68e-73 Breast cancer; BRCA cis rs7914558 0.966 rs1890185 chr10:104748718 A/G cg04362960 chr10:104952993 NT5C2 0.44 10.77 0.39 5.48e-25 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs4845570 0.850 rs4618976 chr1:151766588 A/G cg07092448 chr1:151763213 TDRKH 0.88 18.98 0.6 5.07e-64 Coronary artery disease; BRCA cis rs919433 0.647 rs2045242 chr2:198507649 G/A cg00792783 chr2:198669748 PLCL1 0.4 9.05 0.34 1.69e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs35110281 0.837 rs7279968 chr21:45077398 C/G cg21573476 chr21:45109991 RRP1B -0.34 -9.07 -0.34 1.4e-18 Mean corpuscular volume; BRCA cis rs701145 0.585 rs1713807 chr3:153883344 C/T cg17054900 chr3:154042577 DHX36 0.56 9.47 0.35 5.3e-20 Coronary artery disease; BRCA trans rs10838798 0.504 rs11039627 chr11:48293931 C/T cg00717180 chr2:96193071 NA -0.39 -10.42 -0.38 1.39e-23 Height; BRCA cis rs600231 0.508 rs17146964 chr11:65249145 C/T cg01292856 chr11:65242576 NA -0.66 -14.93 -0.51 1.92e-43 Bone mineral density; BRCA cis rs10927875 0.726 rs1763603 chr1:16339809 T/C cg21385522 chr1:16154831 NA 0.47 8.37 0.31 3.62e-16 Dilated cardiomyopathy; BRCA trans rs61931739 0.929 rs10844748 chr12:34092930 G/T cg26384229 chr12:38710491 ALG10B -0.44 -10.36 -0.38 2.35e-23 Morning vs. evening chronotype; BRCA cis rs427394 0.632 rs169285 chr5:6736587 G/C cg10857441 chr5:6722123 POLS -0.31 -9.97 -0.37 7.32e-22 Menopause (age at onset); BRCA cis rs11051970 0.566 rs2651372 chr12:32583199 A/G cg24626660 chr12:32551988 NA 0.27 8.15 0.31 1.91e-15 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs10540 0.908 rs1044707 chr11:491334 G/T cg03934478 chr11:495069 RNH1 -0.8 -11.97 -0.43 5.91e-30 Body mass index; BRCA cis rs1506636 1.000 rs10225428 chr7:123357646 A/G cg03229431 chr7:123269106 ASB15 -0.6 -13.53 -0.47 7.28e-37 Plateletcrit;Platelet count; BRCA cis rs4819052 0.851 rs2838865 chr21:46712299 C/T cg11663144 chr21:46675770 NA -0.59 -13.76 -0.48 6.24e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs1862618 0.853 rs252902 chr5:56116085 A/G cg22800045 chr5:56110881 MAP3K1 0.69 13.38 0.47 3.5e-36 Initial pursuit acceleration; BRCA cis rs13256369 0.851 rs11249890 chr8:8565245 G/T cg06671706 chr8:8559999 CLDN23 0.45 8.64 0.32 4.57e-17 Obesity-related traits; BRCA trans rs9393777 0.920 rs34150729 chr6:27388754 T/C cg06606381 chr12:133084897 FBRSL1 -0.77 -8.04 -0.3 4.34e-15 Intelligence (multi-trait analysis); BRCA cis rs208520 0.690 rs3846808 chr6:66818604 A/G cg07460842 chr6:66804631 NA -1.0 -19.97 -0.62 2.6e-69 Exhaled nitric oxide output; BRCA cis rs780096 0.526 rs11126999 chr2:27670307 G/A cg17158414 chr2:27665306 KRTCAP3 -0.33 -8.58 -0.32 7.19e-17 Total body bone mineral density; BRCA cis rs244731 0.959 rs6872021 chr5:176610012 G/A cg17509989 chr5:176798049 RGS14 -0.74 -11.79 -0.42 3.79e-29 Urate levels in lean individuals; BRCA cis rs9815354 1.000 rs56158380 chr3:41885588 G/A cg03022575 chr3:42003672 ULK4 0.49 7.99 0.3 6.4e-15 Pulse pressure;Diastolic blood pressure; BRCA cis rs2688482 0.557 rs3103952 chr3:195522690 T/C cg13752114 chr3:195489708 MUC4 0.55 8.76 0.33 1.81e-17 Lung disease severity in cystic fibrosis; BRCA cis rs881375 0.934 rs1468671 chr9:123657502 C/G cg09419670 chr9:123605666 PSMD5;LOC253039 0.5 9.53 0.35 3.19e-20 Rheumatoid arthritis; BRCA cis rs10791323 0.582 rs2851120 chr11:133708065 A/G cg14349672 chr11:133703707 NA -0.39 -9.06 -0.34 1.58e-18 Childhood ear infection; BRCA trans rs11098499 0.754 rs10213267 chr4:120239074 A/G cg25214090 chr10:38739885 LOC399744 0.44 10.29 0.38 4.34e-23 Corneal astigmatism; BRCA trans rs2797160 0.651 rs1343121 chr6:126036184 C/T cg05039488 chr6:79577232 IRAK1BP1 0.37 8.25 0.31 8.73e-16 Endometrial cancer; BRCA trans rs61931739 0.500 rs11053260 chr12:34530215 T/G cg26384229 chr12:38710491 ALG10B 0.59 13.52 0.47 8.1e-37 Morning vs. evening chronotype; BRCA cis rs2832191 0.671 rs2832213 chr21:30512914 A/G cg08807101 chr21:30365312 RNF160 -0.43 -9.12 -0.34 9.51e-19 Dental caries; BRCA cis rs72615157 0.716 rs75779608 chr7:99768957 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.64 9.83 0.36 2.59e-21 Lung function (FEV1/FVC); BRCA cis rs61990749 0.597 rs10136053 chr14:78155205 G/A cg23188588 chr14:78226832 SNW1;C14orf178 -0.44 -7.89 -0.3 1.28e-14 Fibroblast growth factor basic levels; BRCA cis rs853679 0.517 rs9368557 chr6:28131537 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.9 0.3 1.25e-14 Depression; BRCA cis rs9527 0.590 rs11191572 chr10:104893137 A/G cg04362960 chr10:104952993 NT5C2 0.46 10.7 0.39 1.08e-24 Arsenic metabolism; BRCA cis rs7589728 0.514 rs12465706 chr2:88467459 C/A cg04511125 chr2:88470314 THNSL2 0.94 13.51 0.47 9.42e-37 Plasma clusterin levels; BRCA trans rs11976180 1.000 rs2961132 chr7:143768128 A/G cg00397059 chr6:132031294 CTAGE9;ENPP3 -0.45 -8.2 -0.31 1.32e-15 Obesity-related traits; BRCA trans rs79976124 0.879 rs12214948 chr6:66633603 G/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.59 10.52 0.38 5.58e-24 Type 2 diabetes; BRCA cis rs4478858 0.735 rs6425736 chr1:31784376 T/A cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA cis rs10504229 1.000 rs17805656 chr8:58180318 T/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs8062405 0.824 rs4788084 chr16:28539848 C/T cg16576597 chr16:28551801 NUPR1 0.31 8.57 0.32 7.87e-17 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs7677751 0.806 rs7689569 chr4:55096398 G/A cg17187183 chr4:55093834 PDGFRA 0.45 8.86 0.33 8.09e-18 Corneal astigmatism; BRCA cis rs10256972 0.552 rs2960837 chr7:1203957 A/G cg23708337 chr7:1209742 NA 0.56 12.12 0.43 1.36e-30 Longevity;Endometriosis; BRCA cis rs7098414 0.511 rs7071752 chr10:82159539 C/A cg01528321 chr10:82214614 TSPAN14 0.68 14.57 0.5 9.95e-42 Post bronchodilator FEV1; BRCA cis rs13046373 0.535 rs1354866 chr21:31981559 A/T cg16431978 chr21:31797932 KRTAP13-3 0.36 9.15 0.34 7.46e-19 HDL cholesterol; BRCA trans rs1997103 1.000 rs6954474 chr7:55404847 A/G cg20935933 chr6:143382018 AIG1 0.6 11.56 0.42 3.34e-28 QRS interval (sulfonylurea treatment interaction); BRCA trans rs61931739 0.927 rs1906135 chr12:34038103 C/A cg26384229 chr12:38710491 ALG10B -0.42 -9.38 -0.35 1.09e-19 Morning vs. evening chronotype; BRCA cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg18479299 chr3:125709523 NA -0.54 -8.43 -0.32 2.33e-16 Blood pressure (smoking interaction); BRCA cis rs2576037 0.526 rs7234570 chr18:44459656 A/G cg19077165 chr18:44547161 KATNAL2 -0.53 -11.48 -0.41 7.3e-28 Personality dimensions; BRCA cis rs2836950 0.520 rs2836966 chr21:40637521 A/G cg11644478 chr21:40555479 PSMG1 -0.5 -10.65 -0.39 1.66e-24 Menarche (age at onset); BRCA cis rs6570726 0.967 rs373527 chr6:145801861 C/T cg23711669 chr6:146136114 FBXO30 0.61 13.95 0.48 8.19e-39 Lobe attachment (rater-scored or self-reported); BRCA cis rs9463078 0.625 rs1891412 chr6:44760642 T/C cg25276700 chr6:44698697 NA 0.35 8.26 0.31 8.64e-16 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs12048904 0.964 rs8888 chr1:101338324 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.5 12.71 0.45 3.82e-33 Multiple sclerosis; BRCA cis rs34330 0.562 rs17212236 chr12:12855483 G/C cg09462578 chr12:12878428 APOLD1 -0.68 -11.7 -0.42 8.62e-29 Systemic lupus erythematosus; BRCA cis rs12477438 0.605 rs4585080 chr2:99557327 T/C cg08885076 chr2:99613938 TSGA10 -0.55 -12.8 -0.45 1.52e-33 Chronic sinus infection; BRCA cis rs12497850 0.931 rs4974079 chr3:48906469 T/G cg06212747 chr3:49208901 KLHDC8B 0.46 9.35 0.35 1.41e-19 Parkinson's disease; BRCA cis rs1215050 0.791 rs2123100 chr4:98803747 T/C cg05340658 chr4:99064831 C4orf37 0.44 10.13 0.37 1.74e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs780096 0.587 rs10205219 chr2:27568565 T/C cg17158414 chr2:27665306 KRTCAP3 -0.36 -9.63 -0.36 1.4e-20 Total body bone mineral density; BRCA cis rs6424115 0.830 rs3123554 chr1:24196401 C/T cg10978503 chr1:24200527 CNR2 -0.52 -14.09 -0.49 1.79e-39 Immature fraction of reticulocytes; BRCA cis rs7000551 0.725 rs4871998 chr8:22308150 A/T cg12081754 chr8:22256438 SLC39A14 0.41 8.22 0.31 1.1e-15 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs35110281 0.782 rs6518309 chr21:45047992 C/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.45 8.77 0.33 1.64e-17 Mean corpuscular volume; BRCA cis rs847577 0.722 rs6951277 chr7:97711783 A/G cg21770322 chr7:97807741 LMTK2 0.56 16.02 0.54 8.01e-49 Breast cancer; BRCA cis rs7917772 0.636 rs7897384 chr10:104529042 T/G cg11453585 chr10:104263688 ACTR1A;SUFU -0.42 -10.51 -0.38 6.17e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs2204008 0.744 rs11495519 chr12:38060546 C/A cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 2.99e-22 Bladder cancer; BRCA cis rs12479064 0.724 rs4851203 chr2:99986932 T/C cg26064155 chr2:99771622 LIPT1;TSGA10 -0.52 -10.79 -0.39 4.75e-25 Chronic sinus infection; BRCA cis rs4728302 0.869 rs13233715 chr7:133617471 C/T cg07491979 chr7:133331646 EXOC4 0.36 7.84 0.3 1.95e-14 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs703842 1.000 rs4646536 chr12:58157988 A/G cg00677455 chr12:58241039 CTDSP2 0.62 15.3 0.52 2.86e-45 Multiple sclerosis; BRCA cis rs12142240 0.698 rs17413701 chr1:46818452 A/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA trans rs11662586 0.517 rs11662894 chr18:77713591 G/A cg05926928 chr17:57297772 GDPD1 0.47 9.11 0.34 1.04e-18 Exploratory eye movement dysfunction in schizophrenia (responsive search score); BRCA cis rs9790314 1.000 rs336589 chr3:161080358 C/T cg03342759 chr3:160939853 NMD3 -0.54 -11.58 -0.42 2.68e-28 Morning vs. evening chronotype; BRCA cis rs4665809 0.941 rs11126336 chr2:26245931 C/T cg25036284 chr2:26402008 FAM59B -0.62 -10.23 -0.38 7.22e-23 Gut microbiome composition (summer); BRCA cis rs17270561 0.609 rs4711098 chr6:25734339 C/T cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs2559856 1.000 rs10778139 chr12:102083202 C/T cg12924262 chr12:102091054 CHPT1 -0.35 -7.91 -0.3 1.13e-14 Blood protein levels; BRCA cis rs67478160 0.643 rs12891175 chr14:104274166 T/C cg01849466 chr14:104193079 ZFYVE21 -0.44 -11.29 -0.41 4.4e-27 Schizophrenia; BRCA cis rs2014572 0.967 rs10412975 chr19:57770554 C/A cg24459738 chr19:57751996 ZNF805 -0.36 -8.4 -0.32 2.99e-16 Hyperactive-impulsive symptoms; BRCA cis rs7613875 0.620 rs3774734 chr3:50108792 C/A cg24110177 chr3:50126178 RBM5 0.5 14.17 0.49 7.91e-40 Body mass index; BRCA cis rs7666738 0.830 rs4699594 chr4:98980775 T/C cg05340658 chr4:99064831 C4orf37 0.68 17.05 0.56 5.48e-54 Colonoscopy-negative controls vs population controls; BRCA trans rs12458462 0.851 rs3859317 chr18:77443093 A/C cg09220050 chr20:48770642 TMEM189;TMEM189-UBE2V1 -0.45 -8.63 -0.32 4.85e-17 Monocyte count; BRCA cis rs1011018 0.628 rs17177103 chr7:139449161 G/A cg03224163 chr7:139420300 HIPK2 -0.6 -8.97 -0.33 3.36e-18 Systolic blood pressure; BRCA cis rs67311347 1.000 rs11129876 chr3:40401636 C/T cg09455208 chr3:40491958 NA -0.39 -9.11 -0.34 1.02e-18 Renal cell carcinoma; BRCA cis rs10751667 0.621 rs4075990 chr11:976614 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.23 -0.54 7.7e-50 Alzheimer's disease (late onset); BRCA trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.9 -0.3 1.26e-14 Corneal astigmatism; BRCA trans rs7824557 0.724 rs2572398 chr8:11178093 A/C cg08975724 chr8:8085496 FLJ10661 0.43 8.88 0.33 6.65e-18 Retinal vascular caliber; BRCA trans rs61931739 0.513 rs1486889 chr12:33901229 A/G cg13010199 chr12:38710504 ALG10B 0.38 8.37 0.31 3.62e-16 Morning vs. evening chronotype; BRCA cis rs13108904 0.901 rs2293634 chr4:1291711 T/G cg20887711 chr4:1340912 KIAA1530 0.34 7.89 0.3 1.29e-14 Obesity-related traits; BRCA cis rs2516839 0.517 rs1556257 chr1:161051134 A/G cg04981885 chr1:160991156 F11R -0.48 -8.7 -0.33 2.84e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs12586317 0.582 rs731906 chr14:35604543 C/T cg05294307 chr14:35346193 BAZ1A -0.61 -10.38 -0.38 1.91e-23 Psoriasis; BRCA cis rs2304069 0.695 rs6866298 chr5:149439588 A/G cg22760475 chr5:149380129 HMGXB3;TIGD6 0.63 13.02 0.46 1.55e-34 HIV-1 control; BRCA cis rs4478858 0.684 rs7515988 chr1:31731061 C/T cg00250761 chr1:31883323 NA 0.32 8.48 0.32 1.55e-16 Alcohol dependence; BRCA cis rs1552244 0.572 rs6785976 chr3:10168647 A/G cg18598329 chr3:10140678 FANCD2;C3orf24 -0.59 -9.69 -0.36 7.96e-21 Alzheimer's disease; BRCA cis rs13191362 1.000 rs60719662 chr6:163006643 A/C cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.97 0.3 7.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6570726 0.755 rs2092297 chr6:145893765 A/G cg13319975 chr6:146136371 FBXO30 -0.35 -7.98 -0.3 6.95e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs113835537 0.529 rs2277302 chr11:66240882 T/C cg24851651 chr11:66362959 CCS 0.42 8.06 0.3 3.76e-15 Airway imaging phenotypes; BRCA cis rs853679 0.517 rs17711801 chr6:28092307 C/G cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.02 -0.3 5.22e-15 Depression; BRCA cis rs2204008 0.754 rs11181643 chr12:38380553 G/A cg13010199 chr12:38710504 ALG10B 0.5 10.36 0.38 2.35e-23 Bladder cancer; BRCA cis rs9790314 0.663 rs9860360 chr3:160747963 G/A cg03342759 chr3:160939853 NMD3 -0.46 -8.7 -0.33 2.86e-17 Morning vs. evening chronotype; BRCA trans rs11098499 0.954 rs7436506 chr4:120393769 T/C cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.86 0.3 1.67e-14 Corneal astigmatism; BRCA cis rs9368481 0.761 rs9379952 chr6:26987900 A/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.36 -13.3 -0.47 8.04e-36 Autism spectrum disorder or schizophrenia; BRCA cis rs561341 1.000 rs113115092 chr17:30284164 G/A cg23018236 chr17:30244563 NA -0.61 -10.02 -0.37 4.87e-22 Hip circumference adjusted for BMI; BRCA cis rs7666738 0.830 rs9998682 chr4:98939009 T/C cg05340658 chr4:99064831 C4orf37 0.67 16.85 0.55 5.47e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.717 rs2991989 chr1:46082965 C/T cg06784218 chr1:46089804 CCDC17 -0.53 -12.92 -0.45 4.51e-34 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA trans rs911555 0.755 rs12432803 chr14:103930032 C/T cg17675199 chr6:35436792 RPL10A -0.3 -7.88 -0.3 1.36e-14 Intelligence (multi-trait analysis); BRCA cis rs13394619 1.000 rs4669752 chr2:11727988 G/C cg07314298 chr2:11723111 GREB1 -0.53 -11.83 -0.42 2.45e-29 Endometriosis; BRCA cis rs2204008 0.775 rs11514369 chr12:38305411 C/T cg13010199 chr12:38710504 ALG10B 0.5 10.43 0.38 1.31e-23 Bladder cancer; BRCA cis rs921968 0.565 rs6708192 chr2:219592227 A/G cg02176678 chr2:219576539 TTLL4 -0.38 -10.43 -0.38 1.28e-23 Mean corpuscular hemoglobin concentration; BRCA trans rs11098499 0.954 rs2389803 chr4:120393511 A/G cg25214090 chr10:38739885 LOC399744 -0.56 -12.67 -0.45 5.87e-33 Corneal astigmatism; BRCA cis rs2153535 0.580 rs6929206 chr6:8447961 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.49 0.35 4.56e-20 Motion sickness; BRCA cis rs6964587 0.934 rs7811328 chr7:91720931 A/T cg17063962 chr7:91808500 NA 0.53 12.65 0.45 7.05e-33 Breast cancer; BRCA cis rs1011018 0.628 rs1106768 chr7:139473564 C/A cg03224163 chr7:139420300 HIPK2 -0.59 -8.92 -0.33 5.04e-18 Systolic blood pressure; BRCA cis rs7914558 1.000 rs943038 chr10:104826261 T/C cg04362960 chr10:104952993 NT5C2 0.43 10.38 0.38 1.95e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.4 0.38 1.65e-23 Motion sickness; BRCA cis rs72781680 0.846 rs72782114 chr2:24025740 G/A cg08917208 chr2:24149416 ATAD2B 0.88 12.69 0.45 4.46e-33 Lymphocyte counts; BRCA cis rs7729447 0.813 rs7715571 chr5:32690010 A/C cg16267343 chr5:32710456 NPR3 0.45 9.48 0.35 4.98e-20 Blood pressure; BRCA cis rs10256972 0.684 rs4724039 chr7:1111633 A/G cg07308232 chr7:1071921 C7orf50 -0.43 -9.21 -0.34 4.51e-19 Longevity;Endometriosis; BRCA cis rs34779708 0.931 rs13377158 chr10:35370465 A/C cg03585969 chr10:35415529 CREM -0.49 -10.28 -0.38 4.9e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs4819052 0.807 rs28715237 chr21:46673768 C/G cg11663144 chr21:46675770 NA -0.61 -14.18 -0.49 6.95e-40 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2046867 0.862 rs2322611 chr3:72830087 T/G cg25664220 chr3:72788482 NA -0.5 -10.8 -0.39 4.38e-25 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs2749592 0.550 rs12255038 chr10:37869332 T/C cg00409905 chr10:38381863 ZNF37A 0.45 9.18 0.34 5.8e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6580649 0.831 rs1635528 chr12:48395900 C/T cg24011408 chr12:48396354 COL2A1 0.52 8.81 0.33 1.19e-17 Lung cancer; BRCA cis rs10504229 0.638 rs7826839 chr8:58132075 G/T cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA trans rs2048656 0.600 rs1976671 chr8:9679634 A/G cg15556689 chr8:8085844 FLJ10661 0.32 8.38 0.31 3.32e-16 Schizophrenia; BRCA cis rs17711722 0.701 rs55773927 chr7:65337902 T/C cg11764359 chr7:65958608 NA 0.62 13.52 0.47 8.65e-37 Calcium levels; BRCA cis rs654351 0.541 rs556554 chr6:10388774 T/C cg17959970 chr6:10383164 NA -0.41 -8.55 -0.32 8.77e-17 Squamous cell lung carcinoma; BRCA cis rs9470361 0.506 rs4568449 chr6:36621143 A/G cg08179530 chr6:36648295 CDKN1A 0.39 8.46 0.32 1.87e-16 QRS complex (Cornell);QRS duration;Left ventricular fractional shortening; BRCA trans rs2727020 0.729 rs7924782 chr11:49267249 A/G cg00717180 chr2:96193071 NA -0.32 -9.08 -0.34 1.34e-18 Coronary artery disease; BRCA cis rs9487051 0.872 rs9487034 chr6:109605899 A/G cg01475377 chr6:109611718 NA -0.6 -16.68 -0.55 3.8e-52 Reticulocyte fraction of red cells; BRCA cis rs6582630 0.502 rs11522899 chr12:38270637 T/C cg26384229 chr12:38710491 ALG10B 0.76 17.28 0.56 3.49e-55 Drug-induced liver injury (flucloxacillin); BRCA cis rs459482 1.000 rs459498 chr21:42795027 G/A cg14166395 chr21:42792516 MX1 0.51 11.68 0.42 1.02e-28 IgG glycosylation; BRCA cis rs311392 0.902 rs423150 chr8:55092804 C/T cg11783602 chr8:55087084 NA -0.31 -9.07 -0.34 1.49e-18 Pelvic organ prolapse (moderate/severe); BRCA cis rs17620991 1.000 rs17688571 chr7:40862763 C/T cg05119115 chr7:40866195 C7orf10 0.53 8.28 0.31 7.14e-16 Alcohol dependence; BRCA cis rs769267 0.965 rs10419245 chr19:19383755 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.47 9.4 0.35 9.51e-20 Tonsillectomy; BRCA cis rs3733585 0.699 rs6815001 chr4:9958662 G/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs16866061 0.890 rs72972401 chr2:225404668 T/C cg12698349 chr2:225449008 CUL3 0.78 21.23 0.64 4.04e-76 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs2204008 0.687 rs1733404 chr12:38123395 G/T cg13010199 chr12:38710504 ALG10B -0.41 -8.37 -0.31 3.63e-16 Bladder cancer; BRCA cis rs875971 0.861 rs801215 chr7:66011938 A/T cg11764359 chr7:65958608 NA -0.76 -16.82 -0.55 7.85e-53 Aortic root size; BRCA cis rs2075371 0.933 rs1901214 chr7:133945108 C/T cg02659138 chr7:134003124 SLC35B4 -0.35 -10.9 -0.4 1.7e-25 Mean platelet volume; BRCA cis rs7100689 0.646 rs2994390 chr10:82074395 C/A cg00277334 chr10:82204260 NA -0.4 -7.94 -0.3 9.04e-15 Post bronchodilator FEV1; BRCA cis rs7959452 0.557 rs7980883 chr12:69778914 C/T cg14784868 chr12:69753453 YEATS4 0.68 19.87 0.62 8.39e-69 Blood protein levels; BRCA cis rs801193 0.569 rs2707824 chr7:66189243 A/G cg18876405 chr7:65276391 NA 0.48 10.75 0.39 7.14e-25 Aortic root size; BRCA cis rs17604090 1.000 rs114892953 chr7:29676298 G/A cg19413766 chr7:29689036 LOC646762 -0.64 -8.76 -0.33 1.77e-17 Facial emotion recognition;Facial emotion recognition (sad faces); BRCA cis rs1997103 0.954 rs10246216 chr7:55390479 C/T cg17469321 chr7:55412551 NA 0.52 9.82 0.36 2.79e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs17376456 0.542 rs1453003 chr5:93151611 T/C cg25358565 chr5:93447407 FAM172A -0.67 -11.7 -0.42 8.73e-29 Diabetic retinopathy; BRCA cis rs4727027 0.866 rs2373438 chr7:148780287 C/A cg23583168 chr7:148888333 NA -0.81 -18.71 -0.59 1.32e-62 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7618915 0.570 rs11130312 chr3:52675055 A/C cg18404041 chr3:52824283 ITIH1 -0.42 -12.47 -0.44 4.36e-32 Bipolar disorder; BRCA cis rs11599315 0.507 rs12220554 chr10:1341852 C/T cg09624528 chr10:1369823 ADARB2 0.41 8.47 0.32 1.67e-16 Thiazide-induced adverse metabolic effects in hypertensive patients; BRCA cis rs72781680 0.611 rs72783605 chr2:24287864 A/G cg06627628 chr2:24431161 ITSN2 -0.53 -8.67 -0.32 3.68e-17 Lymphocyte counts; BRCA cis rs7589728 1.000 rs6720809 chr2:88528943 T/C cg04511125 chr2:88470314 THNSL2 0.71 10.4 0.38 1.67e-23 Plasma clusterin levels; BRCA cis rs8031584 1.000 rs1474380 chr15:31269235 T/C cg08704250 chr15:31115839 NA -0.35 -8.75 -0.33 1.92e-17 Huntington's disease progression; BRCA cis rs2836950 0.565 rs8134214 chr21:40542367 A/C cg17971929 chr21:40555470 PSMG1 -0.49 -10.86 -0.39 2.48e-25 Menarche (age at onset); BRCA cis rs9291683 0.655 rs3822242 chr4:10094904 T/C cg00071950 chr4:10020882 SLC2A9 -0.52 -12.51 -0.44 2.93e-32 Bone mineral density; BRCA cis rs10046574 0.831 rs7780028 chr7:135092556 A/G cg27474649 chr7:135195673 CNOT4 0.58 8.24 0.31 1e-15 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2404602 0.647 rs907593 chr15:77196953 G/A cg23625390 chr15:77176239 SCAPER -0.54 -12.39 -0.44 9.98e-32 Blood metabolite levels; BRCA cis rs6951245 0.872 rs77569514 chr7:1085508 G/A cg03188948 chr7:1209495 NA 0.84 11.6 0.42 2.4e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10256972 0.721 rs6975972 chr7:1070468 A/G cg23978390 chr7:1156363 C7orf50 0.4 9.05 0.34 1.64e-18 Longevity;Endometriosis; BRCA cis rs9487051 0.773 rs421790 chr6:109543428 T/A cg01475377 chr6:109611718 NA -0.42 -9.79 -0.36 3.63e-21 Reticulocyte fraction of red cells; BRCA cis rs736801 0.808 rs2706396 chr5:131796809 A/C cg07395648 chr5:131743802 NA 0.37 8.5 0.32 1.38e-16 Breast cancer;Mosquito bite size; BRCA cis rs6088580 0.634 rs6059892 chr20:33105766 A/G cg08999081 chr20:33150536 PIGU 0.47 13.11 0.46 6.3e-35 Glomerular filtration rate (creatinine); BRCA cis rs6831352 0.918 rs6813415 chr4:100048509 T/C cg13256891 chr4:100009986 ADH5 -0.52 -9.75 -0.36 4.74e-21 Alcohol dependence; BRCA cis rs60871478 1.000 rs62432860 chr7:807522 G/C cg05535760 chr7:792225 HEATR2 0.71 12.93 0.46 3.86e-34 Cerebrospinal P-tau181p levels; BRCA cis rs7666738 0.830 rs34870112 chr4:99045815 T/G cg05340658 chr4:99064831 C4orf37 0.7 17.51 0.57 2.34e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs1710278 0.505 rs2138278 chr10:127742664 A/G cg22975853 chr10:127789788 ADAM12 0.33 8.15 0.31 1.9e-15 Exploratory eye movement dysfunction in schizophrenia (number of eye fixations); BRCA cis rs6582630 0.502 rs4385963 chr12:38295264 G/A cg26384229 chr12:38710491 ALG10B 0.72 17.02 0.56 7.88e-54 Drug-induced liver injury (flucloxacillin); BRCA cis rs1801251 1.000 rs6724117 chr2:233593660 T/G cg25237894 chr2:233734115 C2orf82 0.4 11.51 0.41 5.56e-28 Coronary artery disease; BRCA cis rs9814567 0.806 rs4535271 chr3:134321669 T/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.53 -16.8 -0.55 9.57e-53 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10504229 0.728 rs17804750 chr8:58155751 T/C cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs10464366 0.746 rs17171537 chr7:39145647 C/T cg15212455 chr7:39170539 POU6F2 0.44 9.69 0.36 8.13e-21 IgG glycosylation; BRCA cis rs2839186 0.560 rs9975345 chr21:47843004 T/C cg10351095 chr21:47802916 PCNT 0.42 9.19 0.34 5.58e-19 Testicular germ cell tumor; BRCA cis rs6912958 0.754 rs6918909 chr6:88247251 A/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.55 -0.32 8.94e-17 Monocyte percentage of white cells; BRCA cis rs7617773 0.817 rs9311421 chr3:48293078 G/A cg11946769 chr3:48343235 NME6 0.56 12.31 0.44 2.02e-31 Coronary artery disease; BRCA cis rs9324022 0.929 rs1004574 chr14:101178067 C/G cg18089426 chr14:101175970 NA 0.64 12.37 0.44 1.13e-31 Plateletcrit; BRCA trans rs7980799 0.682 rs1601007 chr12:33609675 C/G cg26384229 chr12:38710491 ALG10B 0.47 10.13 0.37 1.77e-22 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2011503 1.000 rs78176666 chr19:19636702 T/C cg15839431 chr19:19639596 YJEFN3 -0.42 -9.13 -0.34 8.85e-19 Bipolar disorder; BRCA trans rs629535 0.773 rs655299 chr8:70074534 C/T cg21567404 chr3:27674614 NA 1.01 21.1 0.64 2.2100000000000001e-75 Dupuytren's disease; BRCA cis rs7493 0.950 rs7785846 chr7:95033841 C/T cg01874867 chr7:94954059 PON1 -0.39 -8.04 -0.3 4.23e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7615952 0.688 rs12485622 chr3:125710739 T/C cg05084668 chr3:125655381 ALG1L -0.46 -8.05 -0.3 4.01e-15 Blood pressure (smoking interaction); BRCA cis rs769267 0.965 rs2269873 chr19:19392401 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.48 9.54 0.35 2.93e-20 Tonsillectomy; BRCA cis rs2463822 1.000 rs2513071 chr11:62098387 A/C cg06239285 chr11:62104954 ASRGL1 0.66 11.05 0.4 4.1e-26 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs1003719 0.680 rs7275984 chr21:38505696 C/A cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs965469 1.000 rs6139103 chr20:3361140 T/C cg25506879 chr20:3388711 C20orf194 -0.56 -10.8 -0.39 4.53e-25 IFN-related cytopenia; BRCA cis rs4363385 0.747 rs4845334 chr1:152982998 T/A cg24667326 chr1:152973720 SPRR3 -0.35 -9.91 -0.37 1.21e-21 Inflammatory skin disease; BRCA cis rs921968 0.509 rs3856548 chr2:219398164 C/T cg10223061 chr2:219282414 VIL1 0.3 8.79 0.33 1.42e-17 Mean corpuscular hemoglobin concentration; BRCA cis rs155076 1.000 rs261431 chr13:21865738 A/G cg14456004 chr13:21872349 NA 1.03 20.39 0.63 1.45e-71 White matter hyperintensity burden; BRCA cis rs2294693 0.947 rs4714417 chr6:40987782 A/G cg14418226 chr6:40996092 UNC5CL 0.45 8.25 0.31 9.28e-16 Gastric cancer;Non-cardia gastric cancer; BRCA trans rs208520 1.000 rs12193164 chr6:66978962 C/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.86 14.41 0.5 5.62e-41 Exhaled nitric oxide output; BRCA cis rs6951245 0.935 rs78573577 chr7:1089087 C/A cg23708337 chr7:1209742 NA 0.64 8.93 0.33 4.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4819052 1.000 rs28628220 chr21:46663741 G/C cg11663144 chr21:46675770 NA -0.49 -9.79 -0.36 3.41e-21 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9308433 0.643 rs7412913 chr1:214463228 G/A cg06198575 chr1:214491504 SMYD2 0.49 10.29 0.38 4.37e-23 IgG glycosylation; BRCA cis rs7772486 0.806 rs7740785 chr6:146171299 C/A cg05347473 chr6:146136440 FBXO30 0.38 7.87 0.3 1.57e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs7618915 0.547 rs11130323 chr3:52770277 T/C cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.38e-16 Bipolar disorder; BRCA cis rs67478160 0.619 rs10083370 chr14:104314182 G/A cg26031613 chr14:104095156 KLC1 0.44 8.73 0.33 2.14e-17 Schizophrenia; BRCA cis rs870825 0.616 rs7680835 chr4:185652992 C/G cg04058563 chr4:185651563 MLF1IP -0.73 -15.84 -0.53 6.2e-48 Blood protein levels; BRCA cis rs7615952 0.611 rs35321002 chr3:125612065 G/C cg05084668 chr3:125655381 ALG1L -0.61 -9.14 -0.34 7.94e-19 Blood pressure (smoking interaction); BRCA cis rs9443645 0.901 rs2174739 chr6:79659170 C/T cg05283184 chr6:79620031 NA 0.39 10.03 0.37 4.43e-22 Intelligence (multi-trait analysis); BRCA cis rs1215050 0.791 rs1506438 chr4:98789542 C/T cg05340658 chr4:99064831 C4orf37 0.43 10.1 0.37 2.4e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10751667 0.666 rs4074234 chr11:977715 C/G cg10932868 chr11:921992 NA 0.47 12.11 0.43 1.62e-30 Alzheimer's disease (late onset); BRCA cis rs875971 0.545 rs6961853 chr7:66002022 G/A cg11764359 chr7:65958608 NA 0.64 11.45 0.41 1.01e-27 Aortic root size; BRCA cis rs2180341 0.920 rs1073932 chr6:127682009 G/T cg24812749 chr6:127587940 RNF146 0.82 18.9 0.6 1.35e-63 Breast cancer; BRCA cis rs10504229 0.683 rs57866073 chr8:58139138 A/G cg22535103 chr8:58192502 C8orf71 -0.47 -9.36 -0.35 1.34e-19 Developmental language disorder (linguistic errors); BRCA cis rs10779751 0.770 rs1417131 chr1:11191922 T/C cg08854313 chr1:11322531 MTOR -0.7 -13.62 -0.47 2.76e-37 Body mass index; BRCA cis rs6088590 0.561 rs2295444 chr20:33173883 C/T cg24642439 chr20:33292090 TP53INP2 0.55 12.14 0.43 1.19e-30 Coronary artery disease; BRCA cis rs350251 0.934 rs350209 chr16:12212818 G/C cg06014057 chr16:12226852 SNX29 0.3 7.93 0.3 1e-14 Intelligence (multi-trait analysis); BRCA cis rs867371 0.762 rs12905578 chr15:82581264 T/G cg00614314 chr15:82944287 LOC80154 -0.47 -9.63 -0.36 1.32e-20 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs2625529 0.617 rs62023343 chr15:72174963 C/A cg16672083 chr15:72433130 SENP8 0.65 15.63 0.53 7.49e-47 Red blood cell count; BRCA cis rs7666738 0.830 rs1869082 chr4:98841254 T/A cg17366294 chr4:99064904 C4orf37 0.43 10.18 0.37 1.22e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs875971 0.545 rs12671152 chr7:65776127 G/T cg11764359 chr7:65958608 NA 0.66 11.64 0.42 1.58e-28 Aortic root size; BRCA cis rs11252926 0.574 rs4881254 chr10:453567 C/T cg16386425 chr10:429943 DIP2C -0.41 -8.68 -0.32 3.18e-17 Psychosis in Alzheimer's disease; BRCA cis rs6815814 0.950 rs66979032 chr4:38814700 A/G cg02016764 chr4:38805732 TLR1 -0.59 -8.76 -0.33 1.73e-17 Breast cancer; BRCA cis rs9837602 1.000 rs923470 chr3:99757792 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.6 11.16 0.4 1.5e-26 Breast cancer; BRCA cis rs2075371 0.933 rs1421482 chr7:133964383 A/G cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 8.47e-68 Mean platelet volume; BRCA cis rs6546550 0.901 rs12232914 chr2:70117176 C/T cg02498382 chr2:70120550 SNRNP27 -0.52 -11.62 -0.42 1.88e-28 Prevalent atrial fibrillation; BRCA cis rs1552244 0.572 rs58223482 chr3:10169746 G/C cg13047869 chr3:10149882 C3orf24 0.55 10.19 0.37 1.03e-22 Alzheimer's disease; BRCA cis rs769267 0.895 rs1000237 chr19:19518316 T/A cg01262667 chr19:19385393 TM6SF2 0.41 10.68 0.39 1.28e-24 Tonsillectomy; BRCA cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.44 9.95 0.37 8.86e-22 Aortic root size; BRCA cis rs11711311 0.747 rs7638378 chr3:113343630 T/A cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.43 -9.14 -0.34 8.3e-19 IgG glycosylation; BRCA cis rs2153535 0.580 rs9379213 chr6:8474945 G/A cg07606381 chr6:8435919 SLC35B3 0.65 14.34 0.49 1.19e-40 Motion sickness; BRCA cis rs11792861 0.851 rs17552292 chr9:111891954 C/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.05 0.3 4.1e-15 Menarche (age at onset); BRCA cis rs4363385 0.747 rs2879489 chr1:152970465 A/G cg24667326 chr1:152973720 SPRR3 -0.34 -9.42 -0.35 8.42e-20 Inflammatory skin disease; BRCA cis rs7267979 0.933 rs2261109 chr20:25259200 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.35 9.85 0.36 2.09e-21 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9653442 0.835 rs11885529 chr2:100746935 A/G cg07810366 chr2:100720526 AFF3 -0.3 -7.94 -0.3 9.4e-15 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA trans rs3960554 0.529 rs7793844 chr7:75883147 C/T cg19862616 chr7:65841803 NCRNA00174 0.45 10.39 0.38 1.74e-23 Eotaxin levels; BRCA cis rs4363385 0.765 rs3806221 chr1:153002555 G/T cg24667326 chr1:152973720 SPRR3 -0.32 -8.81 -0.33 1.17e-17 Inflammatory skin disease; BRCA cis rs5758659 0.652 rs4822084 chr22:42435868 A/G cg05082376 chr22:42548792 NA 0.36 8.52 0.32 1.11e-16 Cognitive function; BRCA cis rs4474465 1.000 rs7395344 chr11:78202388 A/G cg27205649 chr11:78285834 NARS2 -0.27 -8.08 -0.3 3.15e-15 Alzheimer's disease (survival time); BRCA cis rs12701220 0.522 rs12701455 chr7:1055409 A/G cg26769984 chr7:1090371 C7orf50 0.45 9.64 0.36 1.22e-20 Bronchopulmonary dysplasia; BRCA cis rs11764590 0.694 rs10241537 chr7:2083358 A/G cg23422044 chr7:1970798 MAD1L1 -0.45 -9.55 -0.35 2.66e-20 Neuroticism; BRCA cis rs1048238 0.935 rs761760 chr1:16342419 A/G cg22431228 chr1:16359049 CLCNKA -0.43 -9.71 -0.36 6.72e-21 Systolic blood pressure; BRCA cis rs9653442 0.835 rs11694875 chr2:100732845 A/G cg07810366 chr2:100720526 AFF3 0.33 8.27 0.31 7.5e-16 Type 1 diabetes;Rheumatoid arthritis;Intelligence (multi-trait analysis); BRCA cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg14298792 chr15:30685198 CHRFAM7A -0.41 -7.93 -0.3 9.58e-15 Huntington's disease progression; BRCA cis rs765787 0.530 rs11854294 chr15:45527996 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.25 0.31 9.02e-16 Uric acid levels; BRCA cis rs10782582 0.609 rs11588643 chr1:76255613 A/G cg03433033 chr1:76189801 ACADM -0.38 -7.87 -0.3 1.5e-14 Daytime sleep phenotypes; BRCA cis rs3780378 0.840 rs10119004 chr9:5071049 C/T cg02405213 chr9:5042618 JAK2 -0.41 -8.13 -0.31 2.16e-15 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs7666738 0.830 rs7673385 chr4:99024922 T/G cg03676636 chr4:99064102 C4orf37 0.2 7.93 0.3 9.65e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9682041 0.627 rs6786374 chr3:170105233 A/G cg11886554 chr3:170076028 SKIL -0.47 -9.52 -0.35 3.41e-20 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs2836974 0.644 rs61300849 chr21:40680194 G/A cg06238570 chr21:40685208 BRWD1 -0.42 -8.52 -0.32 1.15e-16 Cognitive function; BRCA cis rs6964587 0.967 rs55801687 chr7:91762629 C/A cg17063962 chr7:91808500 NA 0.54 12.91 0.45 4.89e-34 Breast cancer; BRCA cis rs965469 0.947 rs6139087 chr20:3329062 T/C cg25506879 chr20:3388711 C20orf194 -0.53 -10.5 -0.38 6.58e-24 IFN-related cytopenia; BRCA cis rs7917772 0.502 rs4919670 chr10:104515799 C/A cg11453585 chr10:104263688 ACTR1A;SUFU -0.37 -9.37 -0.35 1.24e-19 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA trans rs587242 0.910 rs6593608 chr1:96987688 C/T cg10631902 chr5:14652156 NA 0.36 8.63 0.32 4.78e-17 Body mass index (joint analysis main effects and physical activity interaction);Body mass index in physically inactive individuals;Body mass index; BRCA cis rs1555322 0.505 rs591590 chr20:33866028 A/G cg17927777 chr20:33865990 NA -0.48 -9.32 -0.35 1.89e-19 Attention deficit hyperactivity disorder; BRCA cis rs7811142 0.562 rs7786844 chr7:99934008 T/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.06 23.23 0.68 4.96e-87 Platelet count; BRCA cis rs1707322 0.721 rs4559551 chr1:46167533 T/C cg03146154 chr1:46216737 IPP 0.53 11.85 0.42 2e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs703842 1.000 rs10877013 chr12:58165085 C/T cg00677455 chr12:58241039 CTDSP2 0.63 15.54 0.52 2.07e-46 Multiple sclerosis; BRCA cis rs736408 0.609 rs2230535 chr3:52800284 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.13 0.37 1.79e-22 Bipolar disorder; BRCA cis rs10256972 0.967 rs7799110 chr7:1039065 A/G cg07308232 chr7:1071921 C7orf50 -0.39 -8.15 -0.31 1.9e-15 Longevity;Endometriosis; BRCA cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg06636001 chr8:8085503 FLJ10661 -0.58 -12.87 -0.45 7.43e-34 Mood instability; BRCA cis rs12541635 0.677 rs1496181 chr8:107027141 C/T cg10147462 chr8:107024639 NA 0.37 9.93 0.37 1.05e-21 Age of smoking initiation; BRCA cis rs10046574 0.561 rs56014861 chr7:135203027 A/T cg27474649 chr7:135195673 CNOT4 0.66 11.04 0.4 4.84e-26 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs1707322 0.752 rs8179296 chr1:46143791 G/A cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10883723 0.810 rs7912901 chr10:104277440 T/C cg11453585 chr10:104263688 ACTR1A;SUFU 0.65 20.11 0.62 4.48e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs4566357 0.615 rs1800517 chr2:227915832 G/A cg05526886 chr2:227700861 RHBDD1 -0.39 -8.22 -0.31 1.13e-15 Coronary artery disease; BRCA cis rs795544 0.554 rs12186615 chr5:13783861 T/C cg07548982 chr5:13769939 DNAH5 -0.38 -7.92 -0.3 1.06e-14 Corneal astigmatism; BRCA trans rs61931739 0.500 rs4436630 chr12:34394200 C/T cg26384229 chr12:38710491 ALG10B 0.58 13.27 0.46 1.1e-35 Morning vs. evening chronotype; BRCA cis rs4808199 0.948 rs7250368 chr19:19452763 G/A cg03709012 chr19:19516395 GATAD2A 0.91 17.44 0.57 5.35e-56 Nonalcoholic fatty liver disease; BRCA trans rs61931739 0.534 rs2636082 chr12:34061848 T/A cg26384229 chr12:38710491 ALG10B 0.57 12.15 0.43 1.03e-30 Morning vs. evening chronotype; BRCA cis rs7208859 0.623 rs3794796 chr17:29130880 G/C cg13385521 chr17:29058706 SUZ12P 0.76 11.17 0.4 1.41e-26 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs9733 0.818 rs4970926 chr1:150673684 T/C cg18016565 chr1:150552671 MCL1 -0.41 -9.47 -0.35 5.55e-20 Tonsillectomy; BRCA cis rs7044106 0.791 rs7036196 chr9:123479457 A/G cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 14.95 0.51 1.56e-43 Hip circumference adjusted for BMI; BRCA cis rs12760731 0.565 rs34303391 chr1:178178126 T/A cg00404053 chr1:178313656 RASAL2 0.64 7.93 0.3 9.88e-15 Obesity-related traits; BRCA cis rs7666738 0.830 rs28878289 chr4:98855181 C/T cg05340658 chr4:99064831 C4orf37 0.62 14.74 0.5 1.55e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs11229555 0.645 rs11229442 chr11:58196790 C/T cg15696309 chr11:58395628 NA -0.45 -9.72 -0.36 6.4e-21 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs9612 1.000 rs346523 chr19:44260681 A/C cg08581076 chr19:44259116 C19orf61 0.53 9.72 0.36 6.46e-21 Exhaled nitric oxide output; BRCA cis rs1552244 1.000 rs66838678 chr3:10150350 G/A cg00149659 chr3:10157352 C3orf10 0.82 14.28 0.49 2.33e-40 Alzheimer's disease; BRCA cis rs16958440 1.000 rs16958701 chr18:44655241 T/C cg17192377 chr18:44677553 HDHD2 0.68 10.01 0.37 5.3e-22 Sitting height ratio; BRCA cis rs11792861 0.926 rs72607169 chr9:111832471 A/T cg14432460 chr9:111696404 IKBKAP;C9orf6 0.44 8.19 0.31 1.44e-15 Menarche (age at onset); BRCA cis rs7582180 0.629 rs11682557 chr2:100948008 C/A cg14675211 chr2:100938903 LONRF2 0.52 12.01 0.43 4.37e-30 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs10029849 chr4:99059362 T/C cg03676636 chr4:99064102 C4orf37 0.2 7.86 0.3 1.68e-14 Colonoscopy-negative controls vs population controls; BRCA trans rs12517041 1.000 rs1428619 chr5:23282426 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs66530629 0.958 rs1002707 chr1:25051102 C/T cg01905478 chr1:25040257 NA 0.37 8.28 0.31 7.38e-16 Plateletcrit; BRCA cis rs6772849 0.930 rs4857916 chr3:128376014 C/G cg16766828 chr3:128327626 NA -0.39 -8.72 -0.33 2.43e-17 Monocyte percentage of white cells;Monocyte count; BRCA cis rs78707713 0.560 rs61848436 chr10:71247714 C/T cg12610070 chr10:71211762 TSPAN15 -0.32 -10.17 -0.37 1.31e-22 Venous thromboembolism; BRCA cis rs9503598 0.636 rs7745968 chr6:3467745 G/T cg00476032 chr6:3446245 SLC22A23 0.39 9.42 0.35 8.43e-20 Cognitive ability (multi-trait analysis);Cognitive ability;Intelligence (multi-trait analysis); BRCA cis rs7246657 0.943 rs4969487 chr19:37831039 C/T cg23950597 chr19:37808831 NA -0.72 -12.56 -0.44 1.72e-32 Coronary artery calcification; BRCA cis rs2180341 0.814 rs6905553 chr6:127727407 A/G cg27446573 chr6:127587934 RNF146 0.67 15.06 0.51 4.47e-44 Breast cancer; BRCA cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg10295955 chr4:187884368 NA -0.95 -28.09 -0.74 1.17e-113 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 1.000 rs13209728 chr6:162997533 A/C cg14584255 chr6:163149320 PACRG;PARK2 0.45 7.91 0.3 1.15e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2806561 0.729 rs649664 chr1:23324263 C/T cg19743168 chr1:23544995 NA -0.39 -9.42 -0.35 8.09e-20 Height; BRCA cis rs7666738 0.791 rs1115615 chr4:99006614 G/A cg03676636 chr4:99064102 C4orf37 0.2 7.93 0.3 9.65e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs9381040 0.537 rs9462669 chr6:41013659 C/A cg03644281 chr6:41068752 NFYA;LOC221442 -0.39 -8.36 -0.31 4e-16 Alzheimer's disease (late onset); BRCA cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg15145296 chr3:125709740 NA -0.53 -8.38 -0.31 3.25e-16 Blood pressure (smoking interaction); BRCA cis rs13191362 1.000 rs13220181 chr6:163004401 T/A cg14584255 chr6:163149320 PACRG;PARK2 0.46 8.02 0.3 5.09e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7618501 0.699 rs1317154 chr3:49910084 T/C cg21659725 chr3:3221576 CRBN 0.52 13.44 0.47 1.88e-36 Intelligence (multi-trait analysis); BRCA cis rs72781680 0.846 rs72780108 chr2:23986780 G/A cg08917208 chr2:24149416 ATAD2B 0.89 12.98 0.46 2.32e-34 Lymphocyte counts; BRCA cis rs13191362 1.000 rs34052221 chr6:163160803 G/A cg21926612 chr6:163149169 PACRG;PARK2 1.07 15.91 0.53 2.86e-48 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2032447 0.867 rs9295683 chr6:26069495 C/T cg12310025 chr6:25882481 NA -0.42 -9.65 -0.36 1.19e-20 Intelligence (multi-trait analysis); BRCA cis rs2075371 0.863 rs2075370 chr7:133967812 A/G cg20476274 chr7:133979776 SLC35B4 0.67 19.69 0.61 7.98e-68 Mean platelet volume; BRCA cis rs939658 0.805 rs35602654 chr15:79417527 T/A cg17916960 chr15:79447300 NA -0.45 -11.06 -0.4 3.71e-26 Refractive error; BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg18301423 chr5:131593218 PDLIM4 0.32 7.85 0.3 1.78e-14 Acylcarnitine levels; BRCA cis rs2288073 0.896 rs13404513 chr2:24410780 G/A cg26838691 chr2:24397539 C2orf84 -0.48 -8.67 -0.32 3.46e-17 Venous thromboembolism (SNP x SNP interaction); BRCA cis rs7959452 0.503 rs7300266 chr12:69654187 A/G cg14784868 chr12:69753453 YEATS4 0.44 11.53 0.42 4.41e-28 Blood protein levels; BRCA cis rs17601876 0.814 rs34712049 chr15:51560064 C/T cg19946085 chr15:51559439 CYP19A1 -0.38 -10.64 -0.39 1.9e-24 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9487051 1.000 rs9400273 chr6:109632799 A/G cg12927641 chr6:109611667 NA -0.39 -9.54 -0.35 2.95e-20 Reticulocyte fraction of red cells; BRCA cis rs11711311 1.000 rs7645473 chr3:113516187 T/C cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.48 -10.74 -0.39 7.54e-25 IgG glycosylation; BRCA cis rs1008375 0.933 rs10939757 chr4:17694125 T/C cg02297831 chr4:17616191 MED28 0.36 8.47 0.32 1.67e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4665809 1.000 rs4665809 chr2:26251361 C/T cg04944784 chr2:26401820 FAM59B 0.67 11.03 0.4 4.93e-26 Gut microbiome composition (summer); BRCA cis rs1420338 0.933 rs62451689 chr7:34178719 C/T cg01275685 chr7:34179230 BMPER -0.52 -11.54 -0.42 3.96e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs9291683 0.609 rs13149985 chr4:10028390 G/A cg11266682 chr4:10021025 SLC2A9 0.48 12.9 0.45 5.2e-34 Bone mineral density; BRCA trans rs7181230 1.000 rs28587891 chr15:40365106 T/A cg22705835 chr10:65332833 REEP3 -0.41 -9.72 -0.36 6.45e-21 Dehydroepiandrosterone sulphate levels; BRCA trans rs11098499 0.955 rs56386062 chr4:120155135 T/C cg25214090 chr10:38739885 LOC399744 0.51 11.02 0.4 5.39e-26 Corneal astigmatism; BRCA cis rs10504229 0.683 rs11781690 chr8:58132931 C/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.02 -0.34 2.13e-18 Developmental language disorder (linguistic errors); BRCA cis rs1008375 1.000 rs1008375 chr4:17682834 T/C cg15017067 chr4:17643749 FAM184B 0.32 10.0 0.37 5.88e-22 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1005277 0.528 rs2057228 chr10:38515766 T/C cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.58e-27 Extrinsic epigenetic age acceleration; BRCA cis rs17376456 0.877 rs10035340 chr5:93490465 C/T cg25358565 chr5:93447407 FAM172A 1.25 18.92 0.6 1.03e-63 Diabetic retinopathy; BRCA cis rs4689388 0.926 rs5018647 chr4:6292799 A/C cg00701064 chr4:6280414 WFS1 0.67 17.55 0.57 1.46e-56 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs854765 0.624 rs9899634 chr17:17727943 A/T cg04398451 chr17:18023971 MYO15A 0.57 12.08 0.43 2.01e-30 Total body bone mineral density; BRCA cis rs897984 0.542 rs59061704 chr16:31062704 G/C cg02466173 chr16:30829666 NA -0.42 -9.31 -0.35 1.98e-19 Dementia with Lewy bodies; BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg27170947 chr2:26402098 FAM59B 0.95 16.36 0.54 1.59e-50 Gut microbiome composition (summer); BRCA cis rs17253792 0.598 rs12880362 chr14:56017929 G/C cg01858014 chr14:56050164 KTN1 -0.61 -7.99 -0.3 6.09e-15 Putamen volume; BRCA cis rs7659604 0.539 rs56159666 chr4:122782879 G/A cg19748678 chr4:122722346 EXOSC9 0.74 15.94 0.53 2.18e-48 Type 2 diabetes; BRCA cis rs4665809 0.878 rs6748745 chr2:26364190 C/T cg04944784 chr2:26401820 FAM59B -0.73 -11.6 -0.42 2.19e-28 Gut microbiome composition (summer); BRCA cis rs2153535 0.504 rs5001323 chr6:8451605 C/T cg07606381 chr6:8435919 SLC35B3 0.64 14.08 0.49 2.16e-39 Motion sickness; BRCA cis rs9790314 0.663 rs4679924 chr3:160661862 T/C cg03342759 chr3:160939853 NMD3 0.43 8.19 0.31 1.4e-15 Morning vs. evening chronotype; BRCA cis rs10504229 0.954 rs903717 chr8:58167856 A/G cg22535103 chr8:58192502 C8orf71 -0.51 -11.88 -0.43 1.49e-29 Developmental language disorder (linguistic errors); BRCA cis rs477895 0.568 rs34838337 chr11:63870892 T/C cg19465662 chr11:63993652 NUDT22;TRPT1 0.61 9.5 0.35 4.1e-20 Mean platelet volume; BRCA cis rs17376456 0.825 rs35496867 chr5:93220400 T/C cg25358565 chr5:93447407 FAM172A 1.21 18.17 0.58 9.14e-60 Diabetic retinopathy; BRCA cis rs7666738 0.830 rs35951881 chr4:98999474 A/C cg03676636 chr4:99064102 C4orf37 0.21 7.96 0.3 7.83e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7618915 0.547 rs34537256 chr3:52657472 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.09 0.4 2.95e-26 Bipolar disorder; BRCA cis rs751728 0.638 rs4713686 chr6:33787506 C/T cg15252951 chr6:33757062 LEMD2 0.36 8.31 0.31 5.67e-16 Crohn's disease; BRCA cis rs17401966 1.000 rs7520935 chr1:10354271 G/T cg15208524 chr1:10270712 KIF1B 0.37 8.05 0.3 4.08e-15 Hepatocellular carcinoma; BRCA cis rs1451375 0.617 rs745043 chr7:50543955 T/G cg18232548 chr7:50535776 DDC -0.41 -8.64 -0.32 4.56e-17 Malaria; BRCA cis rs826838 0.935 rs11168761 chr12:38997211 C/A cg26384229 chr12:38710491 ALG10B 0.82 21.74 0.65 7.44e-79 Heart rate; BRCA cis rs56104184 0.723 rs116909499 chr19:49407733 C/T cg21252483 chr19:49399788 TULP2 -0.51 -11.08 -0.4 3.1e-26 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs11955398 0.585 rs1117677 chr5:60034675 T/G cg02684056 chr5:59996105 DEPDC1B -0.38 -9.06 -0.34 1.6e-18 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs7734897 chr5:93305402 G/A cg21475434 chr5:93447410 FAM172A 0.65 8.65 0.32 4e-17 Diabetic retinopathy; BRCA cis rs3772130 0.961 rs34667636 chr3:121353291 G/A cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.45 0.35 6.12e-20 Cognitive performance; BRCA cis rs2742234 0.590 rs2435377 chr10:43683600 A/G cg15436174 chr10:43711423 RASGEF1A 0.55 11.38 0.41 1.84e-27 Hirschsprung disease; BRCA trans rs11098499 0.818 rs55825515 chr4:120486402 A/G cg25214090 chr10:38739885 LOC399744 0.56 12.25 0.44 3.83e-31 Corneal astigmatism; BRCA cis rs40363 0.723 rs2736 chr16:3536872 G/A cg22508957 chr16:3507546 NAT15 -0.58 -8.61 -0.32 5.8e-17 Tuberculosis; BRCA cis rs10504229 0.728 rs17804666 chr8:58154473 C/T cg20607798 chr8:58055168 NA 0.53 8.41 0.32 2.62e-16 Developmental language disorder (linguistic errors); BRCA cis rs1552244 0.572 rs113406084 chr3:10170190 T/C cg10729496 chr3:10149963 C3orf24 0.47 7.84 0.3 1.9e-14 Alzheimer's disease; BRCA cis rs2797160 1.000 rs1832938 chr6:125988964 G/C cg05901451 chr6:126070800 HEY2 -0.41 -10.03 -0.37 4.36e-22 Endometrial cancer; BRCA trans rs8073060 0.544 rs2626626 chr17:34026717 A/G cg19694781 chr19:47549865 TMEM160 -1.06 -20.95 -0.64 1.39e-74 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs7829975 0.688 rs7837587 chr8:8378992 T/C cg14343924 chr8:8086146 FLJ10661 0.41 8.55 0.32 9.4e-17 Mood instability; BRCA cis rs1707322 0.963 rs12022335 chr1:46402732 C/A cg06784218 chr1:46089804 CCDC17 0.46 10.92 0.4 1.49e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2120019 0.938 rs3850093 chr15:75318482 A/G cg09165964 chr15:75287851 SCAMP5 0.85 19.34 0.61 6.07e-66 Blood trace element (Zn levels); BRCA cis rs514406 0.505 rs269292 chr1:53187911 T/C cg24675658 chr1:53192096 ZYG11B -0.66 -14.3 -0.49 1.81e-40 Monocyte count; BRCA cis rs1008375 1.000 rs10939748 chr4:17691230 T/C cg15017067 chr4:17643749 FAM184B 0.27 8.07 0.3 3.38e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9527 0.615 rs4917991 chr10:104783833 T/C cg04362960 chr10:104952993 NT5C2 0.44 9.98 0.37 7.02e-22 Arsenic metabolism; BRCA trans rs2270927 0.510 rs4352583 chr5:75576716 A/G cg13563193 chr19:33072644 PDCD5 0.77 9.45 0.35 6.13e-20 Mean corpuscular volume; BRCA cis rs208520 0.770 rs2224422 chr6:66883993 G/A cg07460842 chr6:66804631 NA -0.95 -17.73 -0.57 1.73e-57 Exhaled nitric oxide output; BRCA cis rs35146811 0.520 rs1015538 chr7:99626035 A/G cg22906224 chr7:99728672 NA -0.41 -8.23 -0.31 1.07e-15 Coronary artery disease; BRCA cis rs709400 0.659 rs7160366 chr14:103944137 C/T cg24130564 chr14:104152367 KLC1 -0.35 -7.92 -0.3 1.06e-14 Body mass index; BRCA cis rs7659604 0.676 rs4516739 chr4:122699741 G/T cg20573242 chr4:122745356 CCNA2 0.46 10.19 0.37 1.09e-22 Type 2 diabetes; BRCA cis rs1468333 0.724 rs12514307 chr5:137612143 T/C cg27119451 chr5:137514611 BRD8;KIF20A 0.38 7.97 0.3 7.33e-15 Resting heart rate; BRCA cis rs7267979 0.966 rs8123949 chr20:25388133 C/T cg08601574 chr20:25228251 PYGB -0.34 -8.2 -0.31 1.31e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2153535 0.580 rs6597335 chr6:8527714 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.64e-24 Motion sickness; BRCA cis rs507080 0.922 rs558907 chr11:118558455 A/G cg09144398 chr11:118550485 TREH -0.38 -8.97 -0.33 3.15e-18 Serum metabolite levels; BRCA cis rs9399135 0.967 rs1041480 chr6:135373076 G/T cg24558204 chr6:135376177 HBS1L 0.45 12.33 0.44 1.66e-31 Red blood cell count; BRCA cis rs3733585 0.699 rs6449171 chr4:9965998 C/T cg00071950 chr4:10020882 SLC2A9 0.45 10.67 0.39 1.45e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2625529 0.824 rs35112434 chr15:72448326 G/T cg16672083 chr15:72433130 SENP8 -0.87 -18.09 -0.58 2.27e-59 Red blood cell count; BRCA cis rs7677751 0.806 rs7682912 chr4:55085620 T/G cg17187183 chr4:55093834 PDGFRA 0.46 9.01 0.34 2.33e-18 Corneal astigmatism; BRCA cis rs9443645 0.901 rs9352666 chr6:79572184 C/G cg11833968 chr6:79620685 NA -0.4 -9.15 -0.34 7.38e-19 Intelligence (multi-trait analysis); BRCA cis rs8177253 0.763 rs12769 chr3:133474328 G/A cg16414030 chr3:133502952 NA -0.42 -9.25 -0.34 3.43e-19 Iron status biomarkers; BRCA cis rs9649213 0.614 rs59120980 chr7:98017730 G/A cg09267113 chr7:98030324 BAIAP2L1 -0.58 -15.87 -0.53 4.83e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs10479542 0.583 rs4131080 chr5:179044292 G/A cg00080972 chr5:178986291 RUFY1 0.5 13.05 0.46 1.15e-34 Lung cancer; BRCA trans rs9650657 0.645 rs9969657 chr8:10515278 A/G cg15556689 chr8:8085844 FLJ10661 0.32 8.55 0.32 9.04e-17 Neuroticism; BRCA cis rs7666738 0.830 rs1405767 chr4:98965295 T/C cg17366294 chr4:99064904 C4orf37 0.44 10.45 0.38 1.08e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs7615952 0.576 rs4646748 chr3:125826329 G/A cg04553112 chr3:125709451 NA -0.56 -8.49 -0.32 1.46e-16 Blood pressure (smoking interaction); BRCA cis rs9560113 1.000 rs9555809 chr13:112181401 T/C cg10483660 chr13:112241077 NA 0.32 7.99 0.3 6.49e-15 Menarche (age at onset); BRCA cis rs35110281 0.774 rs162404 chr21:44963264 G/A cg21573476 chr21:45109991 RRP1B -0.36 -9.49 -0.35 4.48e-20 Mean corpuscular volume; BRCA cis rs7917772 0.636 rs7079231 chr10:104527341 A/G cg11453585 chr10:104263688 ACTR1A;SUFU 0.41 10.46 0.38 9.94e-24 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs4363385 0.720 rs1984197 chr1:152962915 C/G cg21543102 chr1:152974771 SPRR3 -0.28 -8.15 -0.31 1.9e-15 Inflammatory skin disease; BRCA cis rs17270561 0.636 rs12194699 chr6:25729229 G/C cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs875971 0.545 rs11770063 chr7:65783016 G/A cg11764359 chr7:65958608 NA 0.65 11.2 0.41 1.03e-26 Aortic root size; BRCA cis rs12477438 0.798 rs2309524 chr2:99659510 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 -0.74 -17.65 -0.57 4.47e-57 Chronic sinus infection; BRCA cis rs6952808 0.595 rs3800916 chr7:2166072 C/T cg00106254 chr7:1943704 MAD1L1 -0.39 -9.52 -0.35 3.47e-20 Bipolar disorder and schizophrenia; BRCA cis rs8031584 0.918 rs34095794 chr15:31269691 C/T cg14829155 chr15:31115871 NA -0.42 -9.78 -0.36 3.74e-21 Huntington's disease progression; BRCA cis rs9649213 0.593 rs12704989 chr7:98029438 G/T cg01877450 chr7:97915802 BRI3 -0.39 -8.8 -0.33 1.25e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs9581857 0.547 rs76435345 chr13:28107638 G/A cg22138327 chr13:27999177 GTF3A 0.55 7.87 0.3 1.47e-14 Psychosis proneness (hypomanic personality scale and perceptual aberration scale); BRCA cis rs17376456 1.000 rs17323433 chr5:93551028 G/A cg25358565 chr5:93447407 FAM172A 1.16 18.09 0.58 2.26e-59 Diabetic retinopathy; BRCA cis rs877529 1.000 rs139404 chr22:39547201 C/T cg12193277 chr22:39547181 CBX7 0.47 13.09 0.46 7.28e-35 Multiple myeloma; BRCA cis rs9399137 0.507 rs4896118 chr6:135276065 A/G cg22676075 chr6:135203613 NA -0.4 -8.21 -0.31 1.26e-15 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs769267 0.965 rs2916068 chr19:19516433 A/G cg19010396 chr19:19431384 KIAA0892;SF4 0.44 8.71 0.33 2.67e-17 Tonsillectomy; BRCA cis rs6087990 0.806 rs2424918 chr20:31382770 C/T cg13636640 chr20:31349939 DNMT3B 0.64 20.32 0.63 3.35e-71 Ulcerative colitis; BRCA cis rs6545883 0.868 rs7594191 chr2:61840018 A/G cg15711740 chr2:61764176 XPO1 0.48 12.14 0.43 1.15e-30 Tuberculosis; BRCA cis rs1008375 0.932 rs6449315 chr4:17590219 A/G cg02297831 chr4:17616191 MED28 0.37 8.01 0.3 5.43e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs7568458 0.684 rs67988001 chr2:85787123 C/T cg02493740 chr2:85810744 VAMP5 -0.54 -11.17 -0.4 1.44e-26 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs1580019 0.522 rs10951340 chr7:32562408 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.37 8.2 0.31 1.29e-15 Cognitive ability; BRCA cis rs4665809 1.000 rs4665298 chr2:26256378 G/A cg08470875 chr2:26401718 FAM59B -0.5 -8.16 -0.31 1.85e-15 Gut microbiome composition (summer); BRCA cis rs6089584 0.606 rs7270666 chr20:60577598 C/T cg06108461 chr20:60628389 TAF4 -0.64 -13.49 -0.47 1.13e-36 Body mass index; BRCA cis rs1008375 0.932 rs2302391 chr4:17660237 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.84 0.33 8.94e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10248839 0.518 rs34011864 chr7:29698499 G/A cg19413766 chr7:29689036 LOC646762 -0.58 -9.19 -0.34 5.33e-19 Facial emotion recognition (angry faces); BRCA cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg09021430 chr5:549028 NA -0.68 -14.24 -0.49 3.76e-40 Lung disease severity in cystic fibrosis; BRCA cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg23173402 chr1:227635558 NA -0.45 -8.33 -0.31 4.89e-16 Major depressive disorder; BRCA trans rs1941687 0.563 rs9947894 chr18:31328720 G/T cg15819921 chr19:927150 ARID3A 0.45 8.49 0.32 1.43e-16 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs2250402 0.510 rs6492926 chr15:40325829 T/G cg10636054 chr15:40330586 SRP14 0.89 13.01 0.46 1.77e-34 Corneal curvature; BRCA cis rs1580019 0.587 rs2392069 chr7:32547154 A/G cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.34 0.31 4.57e-16 Cognitive ability; BRCA trans rs9291683 0.546 rs13120348 chr4:10053155 C/G cg26043149 chr18:55253948 FECH -0.39 -8.57 -0.32 8.06e-17 Bone mineral density; BRCA cis rs11191270 0.554 rs11191275 chr10:104142800 C/T cg15320455 chr10:103880129 LDB1 0.75 11.06 0.4 4.04e-26 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg04944784 chr2:26401820 FAM59B -1.02 -17.0 -0.56 9.06e-54 Gut microbiome composition (summer); BRCA cis rs10789491 0.953 rs1866770 chr1:47182468 G/T cg15501359 chr1:47185051 KIAA0494 0.66 18.2 0.58 6.28e-60 Response to hepatitis C treatment; BRCA cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg03676636 chr4:99064102 C4orf37 0.2 7.87 0.3 1.55e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg07160278 chr7:100027354 MEPCE;ZCWPW1 1.11 18.27 0.59 2.5e-60 Platelet count; BRCA cis rs9790314 0.905 rs6789388 chr3:160970437 G/A cg03342759 chr3:160939853 NMD3 -0.65 -14.14 -0.49 1.05e-39 Morning vs. evening chronotype; BRCA cis rs6684514 1.000 rs10752615 chr1:156248609 T/C cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2239547 0.563 rs6797399 chr3:52905917 G/A cg11645453 chr3:52864694 ITIH4 0.47 10.86 0.39 2.42e-25 Schizophrenia; BRCA cis rs10733682 0.659 rs13292976 chr9:129467340 C/T cg00232160 chr9:129468157 NA 0.39 9.07 0.34 1.44e-18 BMI (adjusted for smoking behaviour);Body mass index;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2836974 0.644 rs9978775 chr21:40694526 A/G cg06238570 chr21:40685208 BRWD1 -0.46 -9.03 -0.34 1.94e-18 Cognitive function; BRCA cis rs782590 0.643 rs5012561 chr2:55742032 G/C cg18811423 chr2:55921094 PNPT1 -0.51 -13.01 -0.46 1.68e-34 Metabolic syndrome; BRCA cis rs4975616 0.807 rs28379291 chr5:1313701 A/G cg26373071 chr5:1325741 CLPTM1L -0.44 -10.33 -0.38 3.1e-23 Lung cancer; BRCA cis rs7044106 0.791 rs2416799 chr9:123480866 G/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.68 14.95 0.51 1.5e-43 Hip circumference adjusted for BMI; BRCA cis rs4588572 0.644 rs6870646 chr5:77741082 G/A cg11547950 chr5:77652471 NA -0.42 -8.04 -0.3 4.5e-15 Triglycerides; BRCA trans rs61931739 0.500 rs10844845 chr12:34381117 C/T cg13010199 chr12:38710504 ALG10B 0.42 9.01 0.34 2.29e-18 Morning vs. evening chronotype; BRCA cis rs9831754 0.704 rs7647185 chr3:78468807 T/C cg06138941 chr3:78371609 NA -0.61 -12.92 -0.46 4.17e-34 Calcium levels; BRCA cis rs6952808 0.531 rs3778998 chr7:2180753 C/A cg03354898 chr7:1950403 MAD1L1 -0.44 -8.96 -0.33 3.42e-18 Bipolar disorder and schizophrenia; BRCA trans rs11764590 0.715 rs9969125 chr7:2088460 C/T cg11693508 chr17:37793320 STARD3 0.52 9.14 0.34 7.91e-19 Neuroticism; BRCA cis rs2836974 0.932 rs73221193 chr21:40554693 C/T cg17971929 chr21:40555470 PSMG1 0.79 18.61 0.59 4.55e-62 Cognitive function; BRCA cis rs4891159 0.824 rs17059362 chr18:74144307 G/A cg24786174 chr18:74118243 ZNF516 -0.77 -18.16 -0.58 1.02e-59 Longevity; BRCA cis rs912057 0.526 rs1294400 chr6:6733421 A/G cg06612196 chr6:6737390 NA -0.57 -14.13 -0.49 1.22e-39 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs6088590 1.000 rs6087625 chr20:33342477 A/G cg24642439 chr20:33292090 TP53INP2 -0.71 -16.39 -0.54 1.13e-50 Coronary artery disease; BRCA cis rs4665809 0.878 rs892448 chr2:26366205 A/G cg26314531 chr2:26401878 FAM59B -0.7 -11.77 -0.42 4.53e-29 Gut microbiome composition (summer); BRCA trans rs4596713 0.568 rs7048937 chr9:71746253 A/G cg16512924 chr15:28394682 HERC2 -0.4 -9.61 -0.36 1.65e-20 Headache; BRCA cis rs806795 0.605 rs809871 chr6:26256526 C/G cg00631329 chr6:26305371 NA 0.49 13.3 0.47 8.69e-36 Mosquito bite size; BRCA cis rs2354432 1.000 rs2354432 chr1:146693229 C/T cg25205988 chr1:146714368 CHD1L 0.95 16.12 0.54 2.57e-49 Mitochondrial DNA levels; BRCA cis rs7481584 0.624 rs2106229 chr11:3041195 G/A cg08508325 chr11:3079039 CARS 0.28 8.51 0.32 1.19e-16 Calcium levels; BRCA trans rs1005277 0.579 rs2472178 chr10:38384750 T/C cg17830980 chr10:43048298 ZNF37B -0.54 -13.02 -0.46 1.52e-34 Extrinsic epigenetic age acceleration; BRCA cis rs4285028 0.948 rs12488334 chr3:121702526 T/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.59 -10.85 -0.39 2.68e-25 Multiple sclerosis; BRCA cis rs7264396 0.790 rs6060530 chr20:34227663 C/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.71 -14.26 -0.49 2.79e-40 Total cholesterol levels; BRCA cis rs13191362 0.507 rs2849524 chr6:163127070 C/T cg06582575 chr6:163149167 PACRG;PARK2 -0.49 -9.33 -0.35 1.76e-19 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs6598955 0.671 rs58038522 chr1:26582713 C/T cg04990556 chr1:26633338 UBXN11 0.54 8.93 0.33 4.42e-18 Obesity-related traits; BRCA cis rs832540 0.618 rs41106 chr5:56145057 G/T cg18230493 chr5:56204884 C5orf35 -0.42 -8.73 -0.33 2.23e-17 Coronary artery disease; BRCA cis rs7772486 0.754 rs9373475 chr6:146126419 C/T cg13319975 chr6:146136371 FBXO30 -0.45 -10.29 -0.38 4.53e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs11608355 0.545 rs12818120 chr12:109901916 C/T cg05360138 chr12:110035743 NA 0.71 13.0 0.46 1.93e-34 Neuroticism; BRCA cis rs60843830 0.964 rs7584915 chr2:264227 G/A cg00108164 chr2:264199 ACP1;SH3YL1 0.72 15.14 0.51 1.79e-44 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg01448562 chr3:133502909 NA -0.63 -14.96 -0.51 1.35e-43 Iron status biomarkers; BRCA cis rs6684514 0.845 rs12138564 chr1:156291600 G/T cg16558208 chr1:156270281 VHLL 0.35 7.97 0.3 7.18e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs2070488 0.804 rs1870914 chr3:38494220 T/C cg24069376 chr3:38537580 EXOG 0.35 9.74 0.36 5.34e-21 Electrocardiographic conduction measures; BRCA cis rs6815814 0.898 rs115807384 chr4:38851585 A/C cg02016764 chr4:38805732 TLR1 -0.52 -7.92 -0.3 1.07e-14 Breast cancer; BRCA cis rs919433 0.617 rs700638 chr2:198588950 A/C cg00792783 chr2:198669748 PLCL1 0.42 9.16 0.34 7.2e-19 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs13191362 0.507 rs13197051 chr6:163201728 A/T cg21926612 chr6:163149169 PACRG;PARK2 0.52 9.91 0.36 1.25e-21 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs2204008 0.774 rs10400552 chr12:38393577 C/G cg06521331 chr12:34319734 NA -0.45 -8.4 -0.32 2.91e-16 Bladder cancer; BRCA cis rs2625529 0.617 rs7175792 chr15:72431883 C/G cg16672083 chr15:72433130 SENP8 -0.67 -16.3 -0.54 3.41e-50 Red blood cell count; BRCA cis rs4665809 0.590 rs4665318 chr2:26424517 C/T cg25036284 chr2:26402008 FAM59B 0.89 15.61 0.53 8.74e-47 Gut microbiome composition (summer); BRCA cis rs6831352 0.734 rs1154400 chr4:100010010 C/T cg13256891 chr4:100009986 ADH5 0.51 10.63 0.39 2.03e-24 Alcohol dependence; BRCA cis rs829883 0.934 rs1641642 chr12:98898726 A/G cg25150519 chr12:98850993 NA 0.6 12.04 0.43 3.07e-30 Colorectal adenoma (advanced); BRCA cis rs6878727 0.589 rs190464 chr5:123668730 T/C cg01806427 chr5:123737813 NA -0.37 -8.26 -0.31 8.69e-16 Breast cancer; BRCA cis rs17376456 0.825 rs10051878 chr5:93064164 T/G cg21475434 chr5:93447410 FAM172A 0.67 8.57 0.32 8.02e-17 Diabetic retinopathy; BRCA cis rs1799922 0.693 rs1688932 chr7:128421135 A/G cg02354431 chr7:128423266 NA 0.36 9.51 0.35 3.76e-20 Primary tooth development (number of teeth);Primary tooth development (time to first tooth eruption); BRCA cis rs3862260 0.509 rs12076924 chr1:120165826 C/T cg16322792 chr1:120165303 ZNF697 0.58 15.27 0.52 4.29e-45 Systemic lupus erythematosus; BRCA cis rs7620457 1.000 rs7620457 chr3:183747266 A/G cg01324343 chr3:183735012 ABCC5 -0.74 -11.55 -0.42 3.54e-28 Body mass index; BRCA cis rs7772486 0.686 rs1337841 chr6:146059487 A/G cg13319975 chr6:146136371 FBXO30 0.34 7.83 0.3 2.03e-14 Lobe attachment (rater-scored or self-reported); BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg03188948 chr7:1209495 NA 0.47 8.8 0.33 1.32e-17 Longevity;Endometriosis; BRCA cis rs13046373 0.535 rs1395778 chr21:31985502 G/C cg06468780 chr21:31798236 KRTAP13-3 0.34 8.37 0.31 3.67e-16 HDL cholesterol; BRCA cis rs2303759 0.543 rs7255778 chr19:49906608 G/A cg22307029 chr19:49891270 CCDC155 0.58 10.44 0.38 1.18e-23 Multiple sclerosis; BRCA cis rs7666738 0.546 rs6827131 chr4:98744810 C/G cg05340658 chr4:99064831 C4orf37 0.57 10.99 0.4 7.15e-26 Colonoscopy-negative controls vs population controls; BRCA trans rs1005277 0.579 rs2505237 chr10:38438898 T/G cg23533926 chr12:111358616 MYL2 -0.42 -8.77 -0.33 1.62e-17 Extrinsic epigenetic age acceleration; BRCA cis rs4363385 0.617 rs5010885 chr1:152973141 C/T cg25856811 chr1:152973957 SPRR3 -0.35 -9.28 -0.34 2.55e-19 Inflammatory skin disease; BRCA cis rs7927771 0.832 rs4752990 chr11:47410393 G/A cg20307385 chr11:47447363 PSMC3 -0.42 -8.65 -0.32 4.01e-17 Subjective well-being; BRCA cis rs17711722 0.522 rs4642526 chr7:65216742 G/T cg18876405 chr7:65276391 NA 0.54 12.22 0.44 5.13e-31 Calcium levels; BRCA cis rs72781680 0.716 rs2712079 chr2:24082061 G/A cg08917208 chr2:24149416 ATAD2B 0.59 10.15 0.37 1.51e-22 Lymphocyte counts; BRCA cis rs10256972 0.758 rs7799391 chr7:1082566 C/G cg16145915 chr7:1198662 ZFAND2A -0.5 -11.49 -0.41 6.64e-28 Longevity;Endometriosis; BRCA cis rs7811142 0.830 rs6945952 chr7:99981775 A/G cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.77 12.63 0.45 8.45e-33 Platelet count; BRCA cis rs798554 0.679 rs2266922 chr7:2824707 G/A cg19717773 chr7:2847554 GNA12 -0.42 -9.47 -0.35 5.5e-20 Height; BRCA cis rs72781680 1.000 rs12617839 chr2:24166277 A/T cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg03354898 chr7:1950403 MAD1L1 -0.4 -8.34 -0.31 4.42e-16 Bipolar disorder and schizophrenia; BRCA trans rs62103177 0.608 rs59300126 chr18:77694439 C/A cg05926928 chr17:57297772 GDPD1 1.0 13.58 0.47 4.5e-37 Opioid sensitivity; BRCA cis rs6942407 0.546 rs3747807 chr7:86800351 A/G cg02420886 chr7:86849541 C7orf23 0.52 7.88 0.3 1.44e-14 Food allergy; BRCA cis rs6142102 0.625 rs1883707 chr20:32552587 A/G cg24642439 chr20:33292090 TP53INP2 -0.4 -7.96 -0.3 7.79e-15 Skin pigmentation; BRCA cis rs9914988 0.943 rs4262997 chr17:27129562 A/G cg20469991 chr17:27169893 C17orf63 -0.45 -8.78 -0.33 1.51e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs4908768 0.539 rs6663123 chr1:8642931 T/C cg20416874 chr1:8611966 RERE -0.28 -8.16 -0.31 1.83e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs12142240 0.698 rs72677592 chr1:46818288 A/G cg10495392 chr1:46806563 NSUN4 0.46 8.43 0.32 2.32e-16 Menopause (age at onset); BRCA cis rs11920090 0.789 rs73169742 chr3:170756779 C/T cg09710316 chr3:170744871 SLC2A2 0.57 8.96 0.33 3.51e-18 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs7178424 0.777 rs8033816 chr15:62233167 A/G cg00456672 chr15:62358751 C2CD4A -0.38 -9.29 -0.35 2.33e-19 Height; BRCA cis rs798554 0.660 rs1182196 chr7:2866478 T/G cg19717773 chr7:2847554 GNA12 -0.43 -9.4 -0.35 9.87e-20 Height; BRCA trans rs6582630 0.555 rs11610015 chr12:38508856 A/G cg06521331 chr12:34319734 NA -0.45 -8.59 -0.32 6.74e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7249142 0.561 rs4808185 chr19:19296217 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.47 -11.25 -0.41 6.51e-27 IgG glycosylation; BRCA cis rs6089829 0.926 rs6062395 chr20:61667904 A/G cg08045932 chr20:61659980 NA 0.5 11.54 0.42 3.98e-28 Prostate cancer (SNP x SNP interaction); BRCA cis rs9814567 0.806 rs4245904 chr3:134321808 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.54 -16.75 -0.55 1.78e-52 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 1.000 rs1560868 chr2:26281459 A/T cg27170947 chr2:26402098 FAM59B 0.69 11.58 0.42 2.77e-28 Gut microbiome composition (summer); BRCA cis rs875971 0.965 rs7794930 chr7:65778546 A/C cg11764359 chr7:65958608 NA -0.79 -18.83 -0.6 2.83e-63 Aortic root size; BRCA cis rs1143633 0.662 rs12990810 chr2:113642532 G/T cg12858261 chr2:113808755 IL1F8 -0.45 -9.18 -0.34 5.99e-19 Allergic disease (asthma, hay fever or eczema); BRCA trans rs7647973 0.626 rs9870858 chr3:49769071 C/T cg21659725 chr3:3221576 CRBN -0.48 -8.87 -0.33 7.34e-18 Menarche (age at onset); BRCA cis rs2180341 1.000 rs6569483 chr6:127658855 G/A cg27446573 chr6:127587934 RNF146 0.89 21.1 0.64 2.1e-75 Breast cancer; BRCA cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg05347473 chr6:146136440 FBXO30 0.41 8.05 0.3 4.05e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs11249608 0.548 rs6867208 chr5:178455575 G/A cg21905437 chr5:178450457 ZNF879 0.52 10.79 0.39 4.73e-25 Pubertal anthropometrics; BRCA cis rs1552244 0.882 rs36006511 chr3:10054191 C/T cg00149659 chr3:10157352 C3orf10 0.78 13.55 0.47 5.8e-37 Alzheimer's disease; BRCA cis rs12200560 0.505 rs59296768 chr6:97075535 C/T cg06623918 chr6:96969491 KIAA0776 0.53 12.73 0.45 3.02e-33 Coronary heart disease; BRCA cis rs4665809 1.000 rs4665308 chr2:26330514 C/A cg22920501 chr2:26401640 FAM59B -0.65 -11.32 -0.41 3.23e-27 Gut microbiome composition (summer); BRCA cis rs1997103 0.906 rs2177806 chr7:55402609 A/T cg17469321 chr7:55412551 NA 0.51 9.72 0.36 6.37e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs881375 0.967 rs1930778 chr9:123641369 A/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.84 0.39 2.95e-25 Rheumatoid arthritis; BRCA cis rs7103648 0.695 rs7933019 chr11:47509137 G/C cg20307385 chr11:47447363 PSMC3 0.79 18.93 0.6 9.01e-64 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg04455712 chr21:45112962 RRP1B 0.41 10.76 0.39 6.02e-25 Mean corpuscular volume; BRCA cis rs8072100 0.871 rs7206971 chr17:45425115 A/G cg25173405 chr17:45401733 C17orf57 0.52 11.22 0.41 8.53e-27 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9612 0.718 rs173202 chr19:44253588 C/T cg08581076 chr19:44259116 C19orf61 0.45 8.3 0.31 6.19e-16 Exhaled nitric oxide output; BRCA cis rs7799006 0.606 rs12669625 chr7:2315950 C/T cg08027265 chr7:2291960 NA -0.46 -11.97 -0.43 6.04e-30 Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7945718 0.935 rs1609442 chr11:12795418 T/A cg25843174 chr11:12811716 TEAD1 0.24 9.35 0.35 1.47e-19 Educational attainment (years of education); BRCA cis rs1552244 0.882 rs13066757 chr3:10045030 C/A cg00166722 chr3:10149974 C3orf24 0.59 11.45 0.41 1e-27 Alzheimer's disease; BRCA cis rs4927850 1.000 rs10881563 chr3:195750225 A/G cg01181863 chr3:195395398 SDHAP2 -0.54 -9.26 -0.34 3.09e-19 Pancreatic cancer; BRCA cis rs6088580 0.634 rs6059868 chr20:33079460 A/G cg24642439 chr20:33292090 TP53INP2 0.53 11.49 0.41 6.44e-28 Glomerular filtration rate (creatinine); BRCA cis rs317689 0.718 rs160827 chr12:69770147 G/A cg14784868 chr12:69753453 YEATS4 0.47 9.28 0.34 2.67e-19 Response to diuretic therapy; BRCA cis rs1577917 1.000 rs12205336 chr6:86722367 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -12.94 -0.46 3.67e-34 Response to antipsychotic treatment; BRCA cis rs4862750 0.872 rs4862747 chr4:187877236 A/T cg10295955 chr4:187884368 NA 0.97 31.28 0.78 5.38e-131 Lobe attachment (rater-scored or self-reported); BRCA cis rs1355223 0.583 rs2915177 chr11:34880266 A/G cg24088639 chr11:34937564 PDHX;APIP -0.42 -9.34 -0.35 1.5700000000000001e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA trans rs2797160 1.000 rs1954361 chr6:126001423 C/G cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.83 -0.3 2.07e-14 Endometrial cancer; BRCA cis rs4363385 0.818 rs678960 chr1:153011621 G/A cg21543102 chr1:152974771 SPRR3 -0.28 -7.83 -0.3 2.09e-14 Inflammatory skin disease; BRCA cis rs2836974 0.965 rs34578707 chr21:40675167 G/A cg11890956 chr21:40555474 PSMG1 0.98 23.1 0.67 2.86e-86 Cognitive function; BRCA cis rs6484504 0.600 rs2761593 chr11:31326752 G/T cg14844989 chr11:31128820 NA 0.44 9.64 0.36 1.22e-20 Red blood cell count; BRCA cis rs477895 0.653 rs2875749 chr11:63903878 C/A cg05016508 chr11:63871570 FLRT1;MACROD1 0.49 8.62 0.32 5.17e-17 Mean platelet volume; BRCA cis rs7267979 0.816 rs8115257 chr20:25207931 A/G cg08601574 chr20:25228251 PYGB 0.35 8.3 0.31 6.41e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9787249 0.874 rs12094291 chr1:40226046 G/A cg02773041 chr1:40204384 PPIE 0.47 9.98 0.37 7.06e-22 Blood protein levels; BRCA cis rs9513627 0.573 rs7325697 chr13:100117793 A/G cg25919922 chr13:100150906 NA 0.55 8.87 0.33 7.35e-18 Obesity-related traits; BRCA trans rs7819412 0.594 rs7460507 chr8:10969075 C/T cg15556689 chr8:8085844 FLJ10661 -0.38 -9.75 -0.36 4.8e-21 Triglycerides; BRCA cis rs586533 0.881 rs629701 chr11:99503431 C/G cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.31 2.76e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2576037 0.542 rs4630643 chr18:44508142 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.59 13.49 0.47 1.12e-36 Personality dimensions; BRCA cis rs312273 0.693 rs11179168 chr12:41345882 A/C cg17827154 chr12:41323612 CNTN1 -0.39 -10.04 -0.37 4.08e-22 Bipolar disorder; BRCA trans rs9329221 0.537 rs1351876 chr8:9984777 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -10.25 -0.38 6.13e-23 Neuroticism; BRCA cis rs589448 0.867 rs623853 chr12:69753830 G/A cg20891283 chr12:69753455 YEATS4 0.84 28.41 0.75 1.93e-115 Cerebrospinal fluid biomarker levels; BRCA trans rs1997103 1.000 rs11238364 chr7:55407632 G/T cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs10479542 0.784 rs7702303 chr5:178986436 G/A cg05457628 chr5:178986728 RUFY1 0.57 14.13 0.49 1.15e-39 Lung cancer; BRCA cis rs6815814 0.861 rs73142654 chr4:38785697 T/A cg06935464 chr4:38784597 TLR10 0.49 9.9 0.36 1.35e-21 Breast cancer; BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg04944784 chr2:26401820 FAM59B 0.99 16.56 0.55 1.61e-51 Gut microbiome composition (summer); BRCA cis rs13191362 1.000 rs35818596 chr6:163001874 C/G cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.25 0.31 9.38e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs459571 0.959 rs408307 chr9:136892523 A/G cg09836344 chr4:1243392 C4orf42;CTBP1 0.71 13.62 0.47 2.98e-37 Platelet distribution width; BRCA trans rs4332037 0.539 rs4470910 chr7:2071723 C/T cg11693508 chr17:37793320 STARD3 0.57 10.76 0.39 6.54e-25 Bipolar disorder; BRCA trans rs9325144 0.600 rs10785615 chr12:38733627 G/C cg23762105 chr12:34175262 ALG10 -0.41 -10.19 -0.37 1.1e-22 Morning vs. evening chronotype; BRCA cis rs9649213 0.593 rs6465683 chr7:98026092 C/A cg24562669 chr7:97807699 LMTK2 0.47 12.33 0.44 1.78e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs4713118 0.513 rs149959 chr6:28013854 T/C cg10876282 chr6:28092338 ZSCAN16 0.41 7.93 0.3 9.66e-15 Parkinson's disease; BRCA cis rs11190604 1.000 rs10883492 chr10:102206089 G/A cg07080220 chr10:102295463 HIF1AN 0.49 11.36 0.41 2.23e-27 Palmitoleic acid (16:1n-7) levels; BRCA cis rs780096 0.506 rs1647265 chr2:27692261 A/G cg02592271 chr2:27665507 KRTCAP3 -0.34 -8.57 -0.32 7.75e-17 Total body bone mineral density; BRCA cis rs801193 1.000 rs3800812 chr7:66223461 T/C cg11764359 chr7:65958608 NA 0.67 15.04 0.51 5.33e-44 Aortic root size; BRCA cis rs9814567 1.000 rs7611828 chr3:134250325 C/T cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.84 -0.33 9.59e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs34779708 0.897 rs34481177 chr10:35380913 C/T cg03585969 chr10:35415529 CREM 0.56 11.55 0.42 3.74e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg22875332 chr1:76189707 ACADM 0.79 18.87 0.6 1.86e-63 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs4319547 0.915 rs7314638 chr12:122983460 A/G cg23029597 chr12:123009494 RSRC2 -0.62 -12.43 -0.44 6.52e-32 Body mass index; BRCA cis rs9611565 0.659 rs9611610 chr22:41949259 A/G cg03806693 chr22:41940476 POLR3H -1.17 -22.48 -0.66 6.33e-83 Vitiligo; BRCA cis rs9527 0.568 rs12772775 chr10:104702999 C/A cg04362960 chr10:104952993 NT5C2 0.45 10.2 0.37 9.66e-23 Arsenic metabolism; BRCA cis rs919433 0.679 rs6757632 chr2:198530266 C/T cg00792783 chr2:198669748 PLCL1 0.39 9.01 0.34 2.27e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs9733 0.519 rs3768005 chr1:150680988 A/T cg04414720 chr1:150670196 GOLPH3L 0.36 8.3 0.31 6.38e-16 Tonsillectomy; BRCA cis rs1371614 0.635 rs6706127 chr2:27140741 C/T cg12368169 chr2:27073192 DPYSL5 -0.29 -8.73 -0.33 2.13e-17 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs752010 0.523 rs943376 chr1:42122117 A/G cg06885757 chr1:42089581 HIVEP3 0.29 9.82 0.36 2.77e-21 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs8180040 0.653 rs6808742 chr3:47051512 G/A cg16586182 chr3:47516702 SCAP -0.57 -12.54 -0.44 2.04e-32 Colorectal cancer; BRCA cis rs3733585 0.781 rs4292328 chr4:9970962 C/T cg00071950 chr4:10020882 SLC2A9 -0.54 -13.23 -0.46 1.66e-35 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs9787249 0.957 rs10888958 chr1:40211737 T/C cg24920358 chr1:40204285 PPIE 0.34 7.87 0.3 1.47e-14 Blood protein levels; BRCA cis rs7666738 0.830 rs6854994 chr4:98977624 C/G cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.19e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs2963155 0.518 rs853176 chr5:142636456 A/G cg17617527 chr5:142782415 NR3C1 -0.52 -8.22 -0.31 1.12e-15 Breast cancer; BRCA trans rs1997103 1.000 rs6951294 chr7:55400835 C/T cg20935933 chr6:143382018 AIG1 0.6 11.42 0.41 1.32e-27 QRS interval (sulfonylurea treatment interaction); BRCA cis rs858239 0.539 rs7791200 chr7:23182121 A/T cg23682824 chr7:23144976 KLHL7 0.41 10.66 0.39 1.52e-24 Cerebrospinal fluid biomarker levels; BRCA cis rs4713118 0.955 rs9380011 chr6:27683924 A/G cg20933634 chr6:27740509 NA 0.44 8.43 0.32 2.27e-16 Parkinson's disease; BRCA cis rs11651000 0.625 rs11079786 chr17:45805916 A/G cg03474202 chr17:45855739 NA 0.41 10.34 0.38 2.73e-23 IgG glycosylation; BRCA cis rs2645694 0.533 rs2645681 chr4:77820949 G/A cg10057126 chr4:77819792 ANKRD56 0.68 15.42 0.52 7.78e-46 Emphysema distribution in smoking; BRCA cis rs10754283 1.000 rs10754283 chr1:90112431 G/T cg21401794 chr1:90099060 LRRC8C 0.46 11.12 0.4 2.31e-26 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs3741404 0.560 rs17699798 chr11:63898806 C/G cg19465662 chr11:63993652 NUDT22;TRPT1 -0.58 -12.74 -0.45 2.65e-33 Platelet count; BRCA trans rs6582630 0.519 rs4002438 chr12:38484880 C/T cg06521331 chr12:34319734 NA -0.47 -8.68 -0.32 3.27e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs7572733 0.555 rs7561950 chr2:198754244 C/T cg00792783 chr2:198669748 PLCL1 0.47 10.08 0.37 2.94e-22 Dermatomyositis; BRCA cis rs2370759 1.000 rs2225152 chr10:32574759 T/C cg18270830 chr10:32634957 EPC1 0.58 10.04 0.37 4.01e-22 Sexual dysfunction (female); BRCA cis rs13256369 0.901 rs13251887 chr8:8568678 G/A cg18904891 chr8:8559673 CLDN23 0.64 12.52 0.44 2.6e-32 Obesity-related traits; BRCA cis rs4975616 0.836 rs13178866 chr5:1323212 C/T cg07493874 chr5:1342172 CLPTM1L -0.51 -14.97 -0.51 1.25e-43 Lung cancer; BRCA cis rs2576037 0.583 rs487386 chr18:44377004 A/G cg15049968 chr18:44337910 ST8SIA5 -0.27 -7.98 -0.3 6.92e-15 Personality dimensions; BRCA cis rs3772130 1.000 rs34086988 chr3:121352745 G/C cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.58 0.35 2.15e-20 Cognitive performance; BRCA cis rs10851411 0.518 rs17767264 chr15:42886656 C/T cg21293051 chr15:42870591 STARD9 0.56 9.26 0.34 3.01e-19 Glucose homeostasis traits; BRCA cis rs10256972 1.000 rs10256972 chr7:1039003 G/T cg07308232 chr7:1071921 C7orf50 0.44 9.39 0.35 1.08e-19 Longevity;Endometriosis; BRCA cis rs7618915 0.571 rs11130307 chr3:52607682 G/A cg10802521 chr3:52805072 NEK4 -0.32 -8.33 -0.31 5.11e-16 Bipolar disorder; BRCA cis rs6714710 0.603 rs6746768 chr2:98466647 C/T cg26665480 chr2:98280029 ACTR1B 0.58 13.44 0.47 1.84e-36 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs459571 0.959 rs461462 chr9:136911272 C/T cg13789015 chr9:136890014 NCRNA00094 0.58 12.2 0.43 6.37e-31 Platelet distribution width; BRCA cis rs3733585 0.673 rs4467563 chr4:9953460 A/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.31 -0.38 3.85e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2204008 0.805 rs7296063 chr12:37964775 T/G cg13010199 chr12:38710504 ALG10B 0.5 10.0 0.37 5.52e-22 Bladder cancer; BRCA cis rs56399783 0.901 rs73051415 chr7:2850643 C/T cg19731401 chr7:2775893 GNA12 0.5 7.88 0.3 1.36e-14 Childhood ear infection; BRCA cis rs1127311 0.901 rs11264223 chr1:154565519 G/A cg17218026 chr1:154582156 ADAR 0.28 8.29 0.31 6.73e-16 C-reactive protein levels or triglyceride levels (pleiotropy); BRCA trans rs11098499 0.775 rs10029303 chr4:120286755 T/A cg19731845 chr4:166199412 KLHL2;GK3P 0.32 7.82 0.3 2.18e-14 Corneal astigmatism; BRCA cis rs9814567 1.000 rs2370578 chr3:134199612 G/A cg06541857 chr3:134203789 ANAPC13;CEP63 -0.38 -8.56 -0.32 8.35e-17 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4588572 0.643 rs1019803 chr5:77739154 A/G cg11547950 chr5:77652471 NA -0.47 -8.42 -0.32 2.41e-16 Triglycerides; BRCA cis rs2625529 0.938 rs2742323 chr15:72116778 A/T cg16672083 chr15:72433130 SENP8 0.82 17.0 0.56 9.56e-54 Red blood cell count; BRCA cis rs13191362 1.000 rs34714518 chr6:163080778 G/A cg18825119 chr6:163149453 PACRG;PARK2 0.56 8.44 0.32 2.13e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs3091242 0.933 rs11802413 chr1:25760920 A/G cg02931644 chr1:25747376 RHCE -0.42 -11.79 -0.42 3.63e-29 Erythrocyte sedimentation rate; BRCA cis rs7772486 0.875 rs6938972 chr6:146410608 G/A cg23711669 chr6:146136114 FBXO30 0.77 17.59 0.57 8.37e-57 Lobe attachment (rater-scored or self-reported); BRCA trans rs459571 0.959 rs465724 chr9:136910097 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.71 -13.94 -0.48 9.39e-39 Platelet distribution width; BRCA cis rs4665809 0.941 rs1434079 chr2:26284670 C/G cg04944784 chr2:26401820 FAM59B -0.69 -11.45 -0.41 9.33e-28 Gut microbiome composition (summer); BRCA cis rs9393777 0.513 rs9393739 chr6:26646966 T/G cg12292205 chr6:26970375 C6orf41 -0.47 -7.96 -0.3 7.59e-15 Intelligence (multi-trait analysis); BRCA cis rs4268898 1.000 rs1203 chr2:24443330 A/G cg06627628 chr2:24431161 ITSN2 0.5 10.36 0.38 2.28e-23 Asthma; BRCA cis rs2505998 0.796 rs2505537 chr10:43592158 T/C cg15436174 chr10:43711423 RASGEF1A -0.43 -8.53 -0.32 1.05e-16 Hirschsprung disease; BRCA cis rs6952808 0.575 rs6950330 chr7:1953606 T/C cg04267008 chr7:1944627 MAD1L1 -0.52 -12.07 -0.43 2.21e-30 Bipolar disorder and schizophrenia; BRCA cis rs6782228 0.585 rs3122175 chr3:128361276 C/T cg16766828 chr3:128327626 NA -0.43 -9.64 -0.36 1.22e-20 Monocyte count;Myeloid white cell count;Sum neutrophil eosinophil counts;Lymphocyte percentage of white cells;White blood cell count;Neutrophil count;Granulocyte count;Sum basophil neutrophil counts; BRCA cis rs738321 0.694 rs4821749 chr22:38542074 A/G cg20207973 chr22:38506712 BAIAP2L2 0.38 9.23 0.34 3.81e-19 Breast cancer; BRCA trans rs3857536 0.785 rs2157964 chr6:66938419 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.21e-15 Blood trace element (Cu levels); BRCA cis rs9329289 0.547 rs4366414 chr10:2561529 C/G cg15501526 chr10:2543763 NA -0.42 -9.0 -0.34 2.6e-18 Age-related hearing impairment; BRCA cis rs3772130 0.583 rs58088236 chr3:121561765 C/T cg01951420 chr3:121553821 IQCB1;EAF2 0.66 14.39 0.49 7.2e-41 Cognitive performance; BRCA cis rs873946 0.564 rs12242672 chr10:134555609 A/T cg13271783 chr10:134563150 INPP5A -0.45 -9.3 -0.35 2.15e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs477895 0.713 rs11601024 chr11:63943074 A/G cg18225595 chr11:63971243 STIP1 0.54 9.74 0.36 5.22e-21 Mean platelet volume; BRCA trans rs3733585 0.654 rs4447863 chr4:9938969 T/C cg26043149 chr18:55253948 FECH -0.42 -9.29 -0.34 2.47e-19 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6831352 0.589 rs2602836 chr4:100014805 C/T cg12011299 chr4:100065546 ADH4 -0.52 -15.0 -0.51 8.9e-44 Alcohol dependence; BRCA cis rs4423214 0.559 rs7949129 chr11:71193135 G/C cg05163923 chr11:71159392 DHCR7 -0.48 -8.47 -0.32 1.7e-16 Vitamin D levels; BRCA cis rs9660992 0.789 rs1768584 chr1:205240145 A/G cg00857998 chr1:205179979 DSTYK 0.41 8.12 0.31 2.39e-15 Mean corpuscular volume;Mean platelet volume; BRCA cis rs2576037 0.796 rs2571032 chr18:44578250 T/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.41 -9.09 -0.34 1.2e-18 Personality dimensions; BRCA cis rs2033711 0.840 rs10423138 chr19:58928302 T/C cg26874164 chr19:58962979 ZNF324B 0.44 9.3 0.35 2.23e-19 Uric acid clearance; BRCA trans rs11098499 0.954 rs7656252 chr4:120404268 T/C cg25517755 chr10:38738941 LOC399744 -0.38 -7.93 -0.3 9.81e-15 Corneal astigmatism; BRCA cis rs68170813 0.559 rs78079372 chr7:106934548 T/G cg02696742 chr7:106810147 HBP1 -0.52 -8.99 -0.33 2.84e-18 Coronary artery disease; BRCA cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg26384229 chr12:38710491 ALG10B -0.55 -13.51 -0.47 9e-37 Morning vs. evening chronotype; BRCA cis rs9420 0.528 rs11229080 chr11:57399511 T/C cg19752551 chr11:57585705 CTNND1 -0.38 -9.45 -0.35 6.29e-20 Schizophrenia; BRCA cis rs2730245 0.851 rs2657333 chr7:158728743 G/A cg14689365 chr7:158441557 NCAPG2 -0.44 -8.97 -0.33 3.39e-18 Height; BRCA cis rs8180040 1.000 rs8180040 chr3:47388947 A/T cg16586182 chr3:47516702 SCAP -0.61 -14.24 -0.49 3.69e-40 Colorectal cancer; BRCA cis rs7267979 0.932 rs431579 chr20:25470056 T/C cg08601574 chr20:25228251 PYGB 0.35 8.41 0.32 2.72e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7914558 0.966 rs10786725 chr10:104682357 T/C cg04362960 chr10:104952993 NT5C2 0.43 10.36 0.38 2.38e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs6542838 0.641 rs4851176 chr2:99534859 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 -0.43 -9.66 -0.36 1.05e-20 Fear of minor pain; BRCA trans rs11098499 0.954 rs9993199 chr4:120392873 A/G cg25214090 chr10:38739885 LOC399744 -0.56 -12.96 -0.46 2.89e-34 Corneal astigmatism; BRCA cis rs7552404 0.691 rs1770890 chr1:76401117 A/G cg10523679 chr1:76189770 ACADM -0.53 -9.82 -0.36 2.67e-21 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs12310956 0.532 rs11052922 chr12:33957476 A/G cg26384229 chr12:38710491 ALG10B 0.47 10.52 0.38 5.39e-24 Morning vs. evening chronotype; BRCA cis rs11105298 0.891 rs10858889 chr12:89902604 G/A cg08166232 chr12:89918718 WDR51B;GALNT4 -0.57 -9.58 -0.35 2.12e-20 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs67460515 0.892 rs73026974 chr3:160963231 A/C cg03342759 chr3:160939853 NMD3 -0.8 -18.89 -0.6 1.45e-63 Parkinson's disease; BRCA cis rs67311347 0.911 rs6775936 chr3:40377399 T/G cg09455208 chr3:40491958 NA 0.4 9.59 0.35 1.9e-20 Renal cell carcinoma; BRCA cis rs1691799 0.899 rs1168315 chr12:66746694 A/G cg16791601 chr12:66731901 HELB -0.69 -19.69 -0.61 8.5e-68 White blood cell count (basophil); BRCA cis rs6582630 0.576 rs4882375 chr12:38371939 G/T cg26384229 chr12:38710491 ALG10B -0.43 -9.76 -0.36 4.45e-21 Drug-induced liver injury (flucloxacillin); BRCA cis rs651907 0.557 rs11917682 chr3:101355427 G/A cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.56 14.78 0.5 9.45e-43 Colorectal cancer; BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg04518342 chr5:131593106 PDLIM4 0.36 9.1 0.34 1.17e-18 Breast cancer; BRCA cis rs72781680 0.821 rs72796361 chr2:24160689 A/T cg08917208 chr2:24149416 ATAD2B 0.64 10.71 0.39 9.64e-25 Lymphocyte counts; BRCA trans rs11098499 0.863 rs10004484 chr4:120442428 C/T cg25214090 chr10:38739885 LOC399744 0.51 11.61 0.42 2.02e-28 Corneal astigmatism; BRCA cis rs73086581 0.838 rs11906481 chr20:4028706 C/T cg02187196 chr20:3869020 PANK2 0.53 9.56 0.35 2.54e-20 Response to antidepressants in depression; BRCA cis rs1577917 0.771 rs3812133 chr6:86354411 C/T cg20289299 chr6:86388069 SNHG5;SNORD50B;SNORD50A -0.35 -7.83 -0.3 2.11e-14 Response to antipsychotic treatment; BRCA cis rs1862618 0.671 rs832531 chr5:56228401 A/G cg22800045 chr5:56110881 MAP3K1 0.45 9.17 0.34 6.29e-19 Initial pursuit acceleration; BRCA trans rs7786808 0.707 rs11770299 chr7:158228822 G/A cg02030672 chr11:45687055 CHST1 0.39 8.28 0.31 7.49e-16 Obesity-related traits; BRCA cis rs9467773 1.000 rs12526680 chr6:26550954 A/G cg09904177 chr6:26538194 HMGN4 0.54 17.26 0.56 4.65e-55 Intelligence (multi-trait analysis); BRCA cis rs9649213 0.593 rs6465677 chr7:98003552 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.63 -0.32 4.68e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs13118159 0.556 rs4974615 chr4:1373551 A/G cg19318889 chr4:1322082 MAEA -0.49 -10.39 -0.38 1.84e-23 Longevity; BRCA cis rs34779708 0.931 rs2384287 chr10:35340559 A/G cg03585969 chr10:35415529 CREM 0.49 10.26 0.38 5.74e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs2576037 0.526 rs9962523 chr18:44486414 A/T cg19077165 chr18:44547161 KATNAL2 -0.5 -10.53 -0.38 5.18e-24 Personality dimensions; BRCA cis rs250677 0.687 rs250671 chr5:148446523 T/C cg18129178 chr5:148520854 ABLIM3 -0.6 -12.19 -0.43 6.89e-31 Breast cancer; BRCA cis rs10754283 0.967 rs6663363 chr1:90116854 A/G cg21401794 chr1:90099060 LRRC8C 0.45 10.87 0.39 2.38e-25 Amyotrophic lateral sclerosis (sporadic); BRCA cis rs13108904 0.557 rs1250086 chr4:1248051 G/A cg16405210 chr4:1374714 KIAA1530 0.65 13.92 0.48 1.12e-38 Obesity-related traits; BRCA cis rs7633857 0.512 rs733948 chr3:160652784 C/G cg03342759 chr3:160939853 NMD3 -0.51 -10.89 -0.4 1.98e-25 Educational attainment (years of education); BRCA cis rs2404602 0.716 rs67888330 chr15:76752483 A/G cg26408565 chr15:76604113 ETFA -0.48 -10.36 -0.38 2.26e-23 Blood metabolite levels; BRCA cis rs7267979 1.000 rs12428 chr20:25433821 G/T cg24626310 chr20:25276739 ABHD12;PYGB -0.31 -8.53 -0.32 1.05e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs270601 0.770 rs10463891 chr5:131597392 C/T cg07262247 chr5:131593730 PDLIM4 -0.38 -9.17 -0.34 6.47e-19 Acylcarnitine levels; BRCA cis rs9814567 1.000 rs2373865 chr3:134291556 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 0.61 19.78 0.62 2.8e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6005807 0.719 rs58049055 chr22:29007850 A/G cg12565055 chr22:29076175 TTC28 0.5 9.42 0.35 7.86e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs651907 0.535 rs34263427 chr3:101507805 A/G cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.35 -0.31 4.34e-16 Colorectal cancer; BRCA cis rs9790314 0.686 rs2306061 chr3:160787502 C/T cg03342759 chr3:160939853 NMD3 -0.46 -8.99 -0.34 2.82e-18 Morning vs. evening chronotype; BRCA cis rs6912958 0.781 rs9444524 chr6:88311260 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.46 -0.32 1.87e-16 Monocyte percentage of white cells; BRCA cis rs651907 0.557 rs1031710 chr3:101463895 C/T cg11279151 chr3:101281821 RG9MTD1 -0.36 -8.17 -0.31 1.64e-15 Colorectal cancer; BRCA cis rs796364 0.951 rs11675980 chr2:201051150 A/G cg23649088 chr2:200775458 C2orf69 -0.63 -10.03 -0.37 4.38e-22 Schizophrenia; BRCA cis rs2204008 0.777 rs11179774 chr12:38219559 A/C cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5.33e-22 Bladder cancer; BRCA cis rs10504229 0.639 rs11781834 chr8:58133422 C/T cg11062466 chr8:58055876 NA 0.41 7.96 0.3 7.98e-15 Developmental language disorder (linguistic errors); BRCA cis rs17095355 1.000 rs11194923 chr10:111695762 A/G cg00817464 chr10:111662876 XPNPEP1 -0.39 -10.13 -0.37 1.88e-22 Biliary atresia; BRCA cis rs10411936 0.682 rs8103805 chr19:16598433 T/G cg10248733 chr19:16607483 C19orf44;CALR3 0.47 9.7 0.36 7.58e-21 White blood cell count;Multiple sclerosis; BRCA cis rs9399137 0.507 rs4594969 chr6:135285586 A/T cg22676075 chr6:135203613 NA 0.42 8.4 0.32 2.81e-16 Glycated hemoglobin levels;Mean corpuscular volume;Hematology traits;HbA2 levels;Mean corpuscular hemoglobin;Hemoglobin levels;F-cell distribution;Platelet count; BRCA cis rs1215050 0.740 rs783936 chr4:98928628 G/T cg05340658 chr4:99064831 C4orf37 -0.46 -10.57 -0.39 3.47e-24 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs8180040 0.701 rs13066214 chr3:47033937 C/T cg02527881 chr3:46936655 PTH1R -0.37 -9.21 -0.34 4.47e-19 Colorectal cancer; BRCA cis rs7520050 1.000 rs12410070 chr1:46358882 T/C cg24296786 chr1:45957014 TESK2 0.43 9.66 0.36 1.06e-20 Red blood cell count;Reticulocyte count; BRCA cis rs10870270 0.956 rs7915388 chr10:133734972 G/A cg26149184 chr10:133730230 NA 0.4 8.2 0.31 1.37e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA trans rs7726839 0.561 rs3915384 chr5:573395 G/T cg25482853 chr8:67687455 SGK3 0.78 13.4 0.47 2.8e-36 Obesity-related traits; BRCA cis rs56104184 0.775 rs117016425 chr19:49400216 C/T cg15549821 chr19:49342101 PLEKHA4 -0.67 -9.72 -0.36 6.19e-21 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs2204008 0.807 rs12816136 chr12:38456037 A/G cg13010199 chr12:38710504 ALG10B -0.39 -8.45 -0.32 2e-16 Bladder cancer; BRCA cis rs6582630 0.576 rs11504369 chr12:38274566 C/T cg26384229 chr12:38710491 ALG10B -0.4 -9.32 -0.35 1.87e-19 Drug-induced liver injury (flucloxacillin); BRCA cis rs6062302 0.534 rs1556456 chr20:62216289 T/C cg03425785 chr20:62221387 GMEB2 0.53 8.6 0.32 6.12e-17 Glioblastoma; BRCA cis rs7267979 0.966 rs6107031 chr20:25350677 C/T cg24626310 chr20:25276739 ABHD12;PYGB -0.33 -9.29 -0.35 2.32e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs13191362 0.935 rs13212137 chr6:163010261 A/G cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs2439831 0.702 rs2467402 chr15:44024490 A/C cg02155558 chr15:43621948 ADAL;LCMT2 -0.6 -11.1 -0.4 2.59e-26 Lung cancer in ever smokers; BRCA cis rs6089584 0.606 rs2296082 chr20:60573983 A/G cg06108461 chr20:60628389 TAF4 -0.64 -13.33 -0.47 6.24e-36 Body mass index; BRCA cis rs9790314 0.779 rs12493960 chr3:160899772 T/C cg03342759 chr3:160939853 NMD3 -0.57 -11.19 -0.4 1.14e-26 Morning vs. evening chronotype; BRCA cis rs9462027 0.628 rs11757370 chr6:34760736 T/C cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.88 -0.3 1.44e-14 Systemic lupus erythematosus; BRCA cis rs6694270 0.913 rs11261069 chr1:19117300 C/G cg19637330 chr1:19110922 NA -0.44 -8.27 -0.31 7.88e-16 Drug-induced liver injury (nitrofurantoin); BRCA cis rs1129187 0.967 rs3805952 chr6:42937126 C/T cg13397359 chr6:42928475 GNMT 0.76 19.52 0.61 6.66e-67 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2404602 0.647 rs11072631 chr15:77132909 T/C cg23625390 chr15:77176239 SCAPER -0.55 -12.82 -0.45 1.22e-33 Blood metabolite levels; BRCA cis rs9921222 1.000 rs9921222 chr16:375782 A/G cg12437481 chr16:420112 MRPL28 0.46 11.47 0.41 8.29e-28 Bone mineral density (spine);Bone mineral density; BRCA cis rs7552404 0.731 rs5745458 chr1:76345429 G/A cg10523679 chr1:76189770 ACADM -0.62 -11.45 -0.41 1.01e-27 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2836974 0.865 rs7282624 chr21:40667040 C/T cg17971929 chr21:40555470 PSMG1 0.77 17.79 0.58 8.63e-58 Cognitive function; BRCA cis rs7618915 0.532 rs13060675 chr3:52674300 T/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.84 0.39 2.89e-25 Bipolar disorder; BRCA cis rs7255436 0.928 rs7250870 chr19:8453682 C/T cg10811474 chr19:8428787 ANGPTL4 -0.31 -7.96 -0.3 8.04e-15 HDL cholesterol; BRCA cis rs586533 0.846 rs592217 chr11:99498738 C/T cg22878054 chr11:99397252 CNTN5 0.32 8.1 0.3 2.89e-15 Depressive symptoms (multi-trait analysis); BRCA cis rs2032447 0.901 rs1540276 chr6:26028819 T/G cg03517284 chr6:25882590 NA -0.48 -10.01 -0.37 5.21e-22 Intelligence (multi-trait analysis); BRCA cis rs9682041 0.696 rs35177863 chr3:170090006 A/G cg11886554 chr3:170076028 SKIL 0.51 10.19 0.37 1.03e-22 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs614226 1.000 rs616157 chr12:120925795 T/C cg01236616 chr12:121019343 POP5 -1.22 -23.92 -0.69 9.07e-91 Type 1 diabetes nephropathy; BRCA cis rs6138458 0.620 rs2151462 chr20:24911823 T/C cg26195577 chr20:24973756 C20orf3 0.98 24.72 0.7 3.46e-95 Blood protein levels; BRCA cis rs2576037 0.583 rs530205 chr18:44385150 C/T cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.59 -0.39 3.04e-24 Personality dimensions; BRCA cis rs9487051 1.000 rs9400272 chr6:109616762 A/G cg01475377 chr6:109611718 NA -0.52 -13.46 -0.47 1.47e-36 Reticulocyte fraction of red cells; BRCA cis rs10504229 1.000 rs113379801 chr8:58173686 C/G cg14926445 chr8:58193284 C8orf71 -0.44 -8.41 -0.32 2.72e-16 Developmental language disorder (linguistic errors); BRCA trans rs7746199 0.736 rs13202291 chr6:27698857 A/G cg06606381 chr12:133084897 FBRSL1 -0.89 -8.85 -0.33 8.51e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs35110281 0.667 rs4819291 chr21:45123139 G/A cg21573476 chr21:45109991 RRP1B -0.39 -10.36 -0.38 2.26e-23 Mean corpuscular volume; BRCA trans rs783540 0.934 rs4779050 chr15:83368738 T/G cg18393722 chr15:85113863 UBE2QP1 0.28 8.69 0.33 3.03e-17 Schizophrenia; BRCA cis rs2516839 0.605 rs12749496 chr1:161021893 G/C cg13567636 chr1:160991154 F11R -0.47 -9.2 -0.34 5.05e-19 Granulocyte percentage of myeloid white cells; BRCA cis rs12188164 0.525 rs2561665 chr5:460135 A/G cg16584290 chr5:462447 EXOC3 0.53 14.91 0.51 2.41e-43 Cystic fibrosis severity; BRCA cis rs10465746 0.780 rs2389648 chr1:84403031 C/T cg10977910 chr1:84465055 TTLL7 0.58 12.02 0.43 3.77e-30 Obesity-related traits; BRCA cis rs427394 0.593 rs880993 chr5:6732120 C/G cg10857441 chr5:6722123 POLS -0.31 -9.91 -0.37 1.23e-21 Menopause (age at onset); BRCA cis rs7474896 0.537 rs2505255 chr10:38359642 C/A cg25427524 chr10:38739819 LOC399744 -0.57 -10.62 -0.39 2.19e-24 Obesity (extreme); BRCA cis rs9389248 0.690 rs6569982 chr6:135256495 C/G cg22676075 chr6:135203613 NA 0.47 9.97 0.37 7.16e-22 High light scatter reticulocyte percentage of red cells; BRCA trans rs7786808 0.536 rs4909210 chr7:158194376 T/C cg02030672 chr11:45687055 CHST1 0.45 10.27 0.38 5.16e-23 Obesity-related traits; BRCA cis rs6089584 0.888 rs6061983 chr20:60621202 T/C cg06108461 chr20:60628389 TAF4 -0.98 -22.16 -0.66 3.66e-81 Body mass index; BRCA cis rs9287719 0.649 rs10207885 chr2:10733188 C/T cg00105475 chr2:10696890 NA 0.42 9.39 0.35 1.06e-19 Prostate cancer; BRCA cis rs4363385 0.747 rs946099 chr1:152971618 A/G cg24667326 chr1:152973720 SPRR3 -0.35 -9.84 -0.36 2.31e-21 Inflammatory skin disease; BRCA cis rs1552244 0.748 rs113890152 chr3:10085986 A/G cg13047869 chr3:10149882 C3orf24 0.59 12.34 0.44 1.6e-31 Alzheimer's disease; BRCA cis rs7020830 0.931 rs3802422 chr9:37097172 G/A cg14294708 chr9:37120828 ZCCHC7 1.16 40.89 0.85 1.52e-180 Schizophrenia; BRCA cis rs208520 1.000 rs72882086 chr6:66976671 G/A cg07460842 chr6:66804631 NA 0.88 14.2 0.49 5.86e-40 Exhaled nitric oxide output; BRCA cis rs1595825 0.838 rs7603283 chr2:198517592 A/G cg19156104 chr2:198669113 PLCL1 -0.43 -8.2 -0.31 1.28e-15 Ulcerative colitis; BRCA cis rs908922 0.573 rs7544564 chr1:152527007 A/C cg20991723 chr1:152506922 NA 0.38 8.71 0.33 2.52e-17 Hair morphology; BRCA cis rs3741404 0.560 rs2875748 chr11:63915537 G/A cg18225595 chr11:63971243 STIP1 -0.41 -10.25 -0.38 6.39e-23 Platelet count; BRCA cis rs372883 0.600 rs2832294 chr21:30739671 A/C cg24692254 chr21:30365293 RNF160 0.46 10.16 0.37 1.39e-22 Pancreatic cancer; BRCA cis rs10504229 0.775 rs55764517 chr8:58158238 G/A cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs473651 0.935 rs474478 chr2:239335473 C/T cg14266287 chr2:239334506 ASB1 -0.34 -8.24 -0.31 1.01e-15 Multiple system atrophy; BRCA cis rs7833790 0.963 rs10958046 chr8:82729210 A/G cg27398817 chr8:82754497 SNX16 -0.47 -9.04 -0.34 1.85e-18 Diastolic blood pressure; BRCA cis rs10504229 0.683 rs58438731 chr8:58134790 C/T cg22535103 chr8:58192502 C8orf71 -0.45 -8.94 -0.33 4.17e-18 Developmental language disorder (linguistic errors); BRCA cis rs12579753 0.597 rs2244802 chr12:82153749 C/G cg07988820 chr12:82153109 PPFIA2 0.41 7.99 0.3 6.18e-15 Resting heart rate; BRCA cis rs11098499 0.818 rs10008791 chr4:120431469 A/C cg09307838 chr4:120376055 NA 0.7 14.19 0.49 5.99e-40 Corneal astigmatism; BRCA trans rs6479891 1.000 rs4745706 chr10:65159580 T/C cg14819942 chr15:35414228 NA 0.35 8.67 0.32 3.63e-17 Arthritis (juvenile idiopathic); BRCA cis rs4819052 0.851 rs9753963 chr21:46661437 G/A cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2019137 0.836 rs4848318 chr2:113953952 T/C cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 -0.6 -12.36 -0.44 1.25e-31 Lymphocyte counts; BRCA cis rs1904096 0.513 rs2632405 chr4:95152215 T/G cg11021082 chr4:95130006 SMARCAD1 -0.43 -10.04 -0.37 4.03e-22 Type 2 diabetes; BRCA trans rs7618501 0.602 rs2526754 chr3:50125996 G/A cg21665057 chr3:196295764 WDR53;FBXO45 -0.34 -9.31 -0.35 1.97e-19 Intelligence (multi-trait analysis); BRCA cis rs17376456 0.877 rs114256265 chr5:93473130 T/A cg21475434 chr5:93447410 FAM172A 0.69 9.09 0.34 1.2e-18 Diabetic retinopathy; BRCA cis rs6860806 0.661 rs2171247 chr5:131580234 G/T cg12564285 chr5:131593104 PDLIM4 0.36 9.77 0.36 4.02e-21 Breast cancer; BRCA cis rs10751667 0.600 rs14346 chr11:1011829 T/C cg06064525 chr11:970664 AP2A2 -0.28 -8.23 -0.31 1.04e-15 Alzheimer's disease (late onset); BRCA cis rs2387326 0.671 rs12256275 chr10:129947139 T/C cg16087940 chr10:129947807 NA -0.47 -8.32 -0.31 5.44e-16 Select biomarker traits; BRCA trans rs9354352 1.000 rs9354352 chr6:66696272 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 13.25 0.46 1.4e-35 Initial pursuit acceleration in psychotic disorders; BRCA cis rs55692411 0.537 rs62262118 chr3:50003586 G/A cg05623727 chr3:50126028 RBM5 0.44 8.49 0.32 1.46e-16 Intelligence (multi-trait analysis); BRCA cis rs1008375 0.966 rs4698621 chr4:17587565 C/T cg04450456 chr4:17643702 FAM184B 0.41 12.33 0.44 1.67e-31 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10267417 0.603 rs13307910 chr7:19858392 C/T cg05791153 chr7:19748676 TWISTNB 0.48 9.46 0.35 5.96e-20 Night sleep phenotypes; BRCA cis rs1375194 0.582 rs13391166 chr2:33805314 C/T cg04131969 chr2:33951647 MYADML 0.44 8.48 0.32 1.57e-16 Response to antidepressants in depression; BRCA cis rs7666738 0.830 rs3911282 chr4:99037602 T/A cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs11603020 1.000 rs11603020 chr11:57374332 C/T cg19752551 chr11:57585705 CTNND1 0.42 9.98 0.37 6.6e-22 Blood protein levels; BRCA cis rs6546550 0.935 rs10202159 chr2:70062454 G/T cg02498382 chr2:70120550 SNRNP27 -0.49 -10.29 -0.38 4.38e-23 Prevalent atrial fibrillation; BRCA cis rs7666738 0.830 rs62321565 chr4:98976571 G/A cg17366294 chr4:99064904 C4orf37 0.44 10.38 0.38 1.98e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs10751667 0.666 rs10794347 chr11:939863 G/A cg06064525 chr11:970664 AP2A2 -0.48 -15.94 -0.53 2.15e-48 Alzheimer's disease (late onset); BRCA cis rs3820928 0.874 rs4675130 chr2:227827740 G/T cg11843606 chr2:227700838 RHBDD1 -0.39 -8.6 -0.32 6.23e-17 Pulmonary function; BRCA cis rs977987 0.788 rs7184525 chr16:75437186 A/G cg03315344 chr16:75512273 CHST6 0.52 12.26 0.44 3.43e-31 Dupuytren's disease; BRCA cis rs4363385 0.747 rs885096 chr1:152971313 T/C cg24667326 chr1:152973720 SPRR3 -0.34 -9.42 -0.35 8e-20 Inflammatory skin disease; BRCA cis rs10256972 0.568 rs1133043 chr7:1133305 C/G cg23978390 chr7:1156363 C7orf50 0.47 11.01 0.4 6.28e-26 Longevity;Endometriosis; BRCA cis rs9814567 1.000 rs9289471 chr3:134230811 A/G cg15484384 chr3:134203672 ANAPC13;CEP63 -0.32 -7.94 -0.3 9.1e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs12367572 1.000 rs12367572 chr12:45290466 C/T cg04608330 chr12:45269318 NELL2 0.63 13.43 0.47 2.12e-36 Gut microbiome composition (summer); BRCA cis rs13191362 1.000 rs13220048 chr6:163004325 T/A cg06582575 chr6:163149167 PACRG;PARK2 0.8 12.12 0.43 1.37e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs35110281 0.837 rs12627667 chr21:45071396 A/C cg21573476 chr21:45109991 RRP1B -0.35 -9.16 -0.34 7.14e-19 Mean corpuscular volume; BRCA cis rs7772486 0.875 rs2748482 chr6:146336532 T/C cg23711669 chr6:146136114 FBXO30 0.72 16.53 0.55 2.2e-51 Lobe attachment (rater-scored or self-reported); BRCA cis rs13191362 1.000 rs35575481 chr6:163007746 T/A cg18825119 chr6:163149453 PACRG;PARK2 0.47 7.81 0.3 2.32e-14 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs12142240 0.698 rs41294476 chr1:46818374 C/A cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs1577917 0.883 rs9450375 chr6:86756629 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.33 8.82 0.33 1.06e-17 Response to antipsychotic treatment; BRCA cis rs1580019 0.587 rs7805311 chr7:32558302 A/G cg06627557 chr7:32535165 LSM5;AVL9 -1.05 -30.14 -0.77 7.83e-125 Cognitive ability; BRCA cis rs8072100 0.748 rs9908016 chr17:45551361 G/A cg25173405 chr17:45401733 C17orf57 -0.52 -11.12 -0.4 2.26e-26 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA trans rs11098499 0.722 rs7673476 chr4:120248683 C/T cg25214090 chr10:38739885 LOC399744 0.43 9.81 0.36 2.9e-21 Corneal astigmatism; BRCA cis rs9359856 0.564 rs56084221 chr6:90365349 T/C cg13799429 chr6:90582589 CASP8AP2 -0.64 -8.54 -0.32 9.91e-17 Bipolar disorder; BRCA cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg06115741 chr20:33292138 TP53INP2 0.41 9.18 0.34 6.11e-19 Coronary artery disease; BRCA trans rs12310956 0.532 rs10506119 chr12:33963684 A/G cg13010199 chr12:38710504 ALG10B 0.48 9.46 0.35 5.66e-20 Morning vs. evening chronotype; BRCA cis rs9443645 0.869 rs9443621 chr6:79576499 A/G cg18132916 chr6:79620363 NA -0.44 -10.06 -0.37 3.3e-22 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs35840293 chr8:58117634 C/T cg20607798 chr8:58055168 NA 0.48 8.39 0.32 3.08e-16 Developmental language disorder (linguistic errors); BRCA cis rs6964587 1.000 rs7806157 chr7:91601930 A/G cg22117172 chr7:91764530 CYP51A1 0.23 8.01 0.3 5.3e-15 Breast cancer; BRCA cis rs7246967 0.611 rs2194113 chr19:22958075 C/T cg23217946 chr19:22817039 ZNF492 0.5 9.11 0.34 1.04e-18 Bronchopulmonary dysplasia; BRCA cis rs6005807 0.719 rs12169460 chr22:29042079 A/G cg12565055 chr22:29076175 TTC28 0.5 9.36 0.35 1.32e-19 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs17270561 0.723 rs12213243 chr6:25890108 C/T cg16482183 chr6:26056742 HIST1H1C 0.75 14.65 0.5 4.12e-42 Iron status biomarkers; BRCA cis rs2732480 0.577 rs1489109 chr12:48738780 C/A cg04545296 chr12:48745243 ZNF641 0.25 8.31 0.31 5.74e-16 Hemoglobin concentration;Red blood cell count;Hematocrit; BRCA cis rs9649213 0.593 rs6970990 chr7:97925382 T/G cg21770322 chr7:97807741 LMTK2 0.44 11.86 0.42 1.77e-29 Prostate cancer (SNP x SNP interaction); BRCA cis rs7659604 0.539 rs7699776 chr4:122753885 A/G cg20573242 chr4:122745356 CCNA2 0.47 10.57 0.39 3.63e-24 Type 2 diabetes; BRCA cis rs4930561 0.714 rs1540209 chr11:67928520 A/C cg04465784 chr11:67976953 SUV420H1 -0.28 -9.26 -0.34 3.17e-19 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs2032447 0.714 rs199726 chr6:25953360 G/A cg03517284 chr6:25882590 NA -0.46 -9.67 -0.36 9.59e-21 Intelligence (multi-trait analysis); BRCA cis rs875971 1.000 rs6957199 chr7:65978519 T/C cg11764359 chr7:65958608 NA 0.8 19.21 0.61 2.94e-65 Aortic root size; BRCA cis rs6840360 0.593 rs1429559 chr4:152681952 A/G cg22705602 chr4:152727874 NA -0.38 -10.39 -0.38 1.81e-23 Intelligence (multi-trait analysis); BRCA cis rs7590368 0.961 rs12474895 chr2:10957848 A/C cg15705551 chr2:10952987 PDIA6 0.44 8.14 0.31 2.1e-15 Educational attainment (years of education); BRCA cis rs10751667 0.621 rs7394681 chr11:952111 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.68 0.55 4.09e-52 Alzheimer's disease (late onset); BRCA trans rs11098499 0.954 rs7437420 chr4:120312903 A/G cg25214090 chr10:38739885 LOC399744 0.51 11.61 0.42 2e-28 Corneal astigmatism; BRCA cis rs897984 0.806 rs8050588 chr16:30937799 G/A cg00531865 chr16:30841666 NA -0.41 -9.7 -0.36 7.77e-21 Dementia with Lewy bodies; BRCA cis rs7617773 0.817 rs9818937 chr3:48325281 G/A cg11946769 chr3:48343235 NME6 0.63 13.47 0.47 1.45e-36 Coronary artery disease; BRCA cis rs6866344 0.697 rs11742808 chr5:178131658 G/A cg03877680 chr5:178157825 ZNF354A 0.79 14.75 0.5 1.38e-42 Neutrophil percentage of white cells; BRCA cis rs4974559 0.947 rs28509315 chr4:1358107 C/T cg02980000 chr4:1222292 CTBP1 0.77 12.64 0.45 7.38e-33 Systolic blood pressure; BRCA cis rs875971 0.862 rs3926380 chr7:66080645 G/T cg18876405 chr7:65276391 NA -0.5 -10.98 -0.4 8.51e-26 Aortic root size; BRCA cis rs12410462 1.000 rs1587158 chr1:227658753 G/A cg04117972 chr1:227635322 NA -0.46 -8.39 -0.31 3.13e-16 Major depressive disorder; BRCA cis rs651907 0.514 rs11706494 chr3:101509475 A/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.35 -0.31 4.34e-16 Colorectal cancer; BRCA cis rs6066835 1.000 rs4516495 chr20:47316482 A/G cg18078177 chr20:47281410 PREX1 0.61 7.95 0.3 8.49e-15 Multiple myeloma; BRCA cis rs11190604 1.000 rs2295774 chr10:102265847 A/C cg07080220 chr10:102295463 HIF1AN 0.6 13.28 0.47 1.03e-35 Palmitoleic acid (16:1n-7) levels; BRCA cis rs6665290 0.935 rs6693535 chr1:227197685 G/A cg10327440 chr1:227177885 CDC42BPA -1.16 -48.97 -0.89 1.81e-218 Myeloid white cell count; BRCA cis rs56804039 1.000 rs34154295 chr8:8383477 C/T cg06636001 chr8:8085503 FLJ10661 -0.55 -9.19 -0.34 5.54e-19 Cervical cancer; BRCA cis rs752010 0.967 rs10890151 chr1:42101843 C/A cg06885757 chr1:42089581 HIVEP3 0.23 8.4 0.32 2.93e-16 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs6500602 0.701 rs6500614 chr16:4573938 A/G cg14951292 chr16:4525986 HMOX2;NMRAL1 0.39 8.08 0.3 3.14e-15 Schizophrenia; BRCA trans rs7618501 0.633 rs4688757 chr3:50035323 T/C cg21665057 chr3:196295764 WDR53;FBXO45 0.34 9.4 0.35 9.78e-20 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs17802743 chr8:58105897 C/T cg20607798 chr8:58055168 NA 0.61 9.77 0.36 4.27e-21 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.954 rs11940028 chr4:120411907 T/C cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.76e-30 Corneal astigmatism; BRCA cis rs8072100 0.713 rs8075058 chr17:45482857 A/G cg08085267 chr17:45401833 C17orf57 -0.58 -12.14 -0.43 1.21e-30 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs6952808 0.743 rs4719308 chr7:1877502 T/G cg14004847 chr7:1930337 MAD1L1 -0.43 -8.75 -0.33 1.93e-17 Bipolar disorder and schizophrenia; BRCA cis rs1865760 0.713 rs6928951 chr6:25995554 C/T cg17691542 chr6:26056736 HIST1H1C 0.51 10.73 0.39 7.99e-25 Height; BRCA cis rs11098499 0.954 rs10006525 chr4:120408931 T/G cg09307838 chr4:120376055 NA 0.74 15.99 0.53 1.14e-48 Corneal astigmatism; BRCA cis rs4073582 0.595 rs801736 chr11:65928430 A/T cg16950941 chr11:66035639 RAB1B 0.45 12.09 0.43 1.95e-30 Gout; BRCA cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg23711669 chr6:146136114 FBXO30 0.75 17.25 0.56 4.8e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs9463078 0.702 rs929614 chr6:44771934 C/A cg25276700 chr6:44698697 NA -0.39 -8.97 -0.33 3.16e-18 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs1011018 0.628 rs79125145 chr7:139451168 C/T cg03224163 chr7:139420300 HIPK2 -0.6 -9.15 -0.34 7.69e-19 Systolic blood pressure; BRCA cis rs36051895 0.530 rs4425810 chr9:5222208 A/G cg02405213 chr9:5042618 JAK2 -0.42 -7.93 -0.3 9.78e-15 Pediatric autoimmune diseases; BRCA cis rs763014 0.932 rs2384974 chr16:651279 C/G cg09256448 chr16:638327 NA 0.3 8.09 0.3 3.01e-15 Height; BRCA cis rs10504229 1.000 rs34616626 chr8:58184650 C/T cg22535103 chr8:58192502 C8orf71 -0.62 -13.52 -0.47 8.28e-37 Developmental language disorder (linguistic errors); BRCA cis rs4975616 0.869 rs31484 chr5:1337906 A/T cg26373071 chr5:1325741 CLPTM1L 0.48 11.33 0.41 3.05e-27 Lung cancer; BRCA cis rs12545109 0.800 rs2670054 chr8:57421616 C/T cg09654669 chr8:57350985 NA -0.39 -8.52 -0.32 1.1e-16 Obesity-related traits; BRCA trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21665057 chr3:196295764 WDR53;FBXO45 0.35 8.94 0.33 4.02e-18 Resting heart rate; BRCA cis rs5758511 0.596 rs55644935 chr22:42666069 A/G cg00645731 chr22:42541494 CYP2D7P1 0.49 9.77 0.36 4.01e-21 Birth weight; BRCA cis rs2070488 0.775 rs6599211 chr3:38558830 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.6 -15.72 -0.53 2.66e-47 Electrocardiographic conduction measures; BRCA trans rs6089829 0.962 rs11086151 chr20:61664644 C/T cg15934090 chr1:100435551 SLC35A3 0.36 8.43 0.32 2.38e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg18402987 chr7:1209562 NA 0.47 9.0 0.34 2.52e-18 Longevity;Endometriosis; BRCA cis rs10504229 0.683 rs72649187 chr8:58108320 A/G cg08219700 chr8:58056026 NA 0.44 7.98 0.3 6.64e-15 Developmental language disorder (linguistic errors); BRCA cis rs208520 0.526 rs9351542 chr6:66788571 A/G cg07460842 chr6:66804631 NA -1.18 -38.99 -0.84 3.98e-171 Exhaled nitric oxide output; BRCA cis rs10464366 0.746 rs4723821 chr7:39141532 A/G cg15212455 chr7:39170539 POU6F2 0.4 8.72 0.33 2.33e-17 IgG glycosylation; BRCA trans rs10242455 0.702 rs59240302 chr7:99072991 C/G cg09045935 chr12:6379348 NA 0.87 8.57 0.32 7.88e-17 Blood metabolite levels; BRCA cis rs1862618 0.853 rs252922 chr5:56136343 G/T cg24531977 chr5:56204891 C5orf35 -0.88 -19.04 -0.6 2.35e-64 Initial pursuit acceleration; BRCA cis rs10504229 1.000 rs72650900 chr8:58185675 T/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.65 -0.32 4.29e-17 Developmental language disorder (linguistic errors); BRCA cis rs701145 0.537 rs357479 chr3:153891489 A/G cg17054900 chr3:154042577 DHX36 0.56 9.48 0.35 4.82e-20 Coronary artery disease; BRCA cis rs12142240 0.698 rs7548675 chr1:46809321 C/G cg00530320 chr1:46809349 NSUN4 0.49 9.68 0.36 8.65e-21 Menopause (age at onset); BRCA cis rs780096 0.526 rs2911713 chr2:27640980 G/A cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.53 -0.32 1.07e-16 Total body bone mineral density; BRCA cis rs17376456 0.825 rs13155452 chr5:93164449 C/T cg21475434 chr5:93447410 FAM172A -0.63 -8.05 -0.3 3.98e-15 Diabetic retinopathy; BRCA cis rs858239 0.600 rs6461690 chr7:23135534 A/G cg23682824 chr7:23144976 KLHL7 0.45 11.89 0.43 1.36e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs1008375 0.868 rs6816286 chr4:17698088 A/G cg02297831 chr4:17616191 MED28 0.36 8.51 0.32 1.2e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs875971 1.000 rs4718357 chr7:65960878 A/G cg18876405 chr7:65276391 NA 0.55 13.16 0.46 3.77e-35 Aortic root size; BRCA cis rs1862618 0.853 rs6885541 chr5:56110857 G/C cg12311346 chr5:56204834 C5orf35 -0.79 -15.4 -0.52 9.6e-46 Initial pursuit acceleration; BRCA trans rs629535 0.734 rs659430 chr8:70009988 A/G cg21567404 chr3:27674614 NA 0.7 15.2 0.52 9.14e-45 Dupuytren's disease; BRCA cis rs79976124 0.879 rs12214948 chr6:66633603 G/A cg07460842 chr6:66804631 NA 0.59 10.16 0.37 1.4e-22 Type 2 diabetes; BRCA cis rs2130392 0.926 rs7677893 chr4:185625523 T/C cg21366198 chr4:185655624 MLF1IP -0.43 -10.39 -0.38 1.83e-23 Kawasaki disease; BRCA cis rs35306767 0.714 rs10508206 chr10:1075777 A/C cg20503657 chr10:835505 NA 0.65 11.19 0.4 1.17e-26 Eosinophil percentage of granulocytes; BRCA cis rs2580764 0.573 rs13387751 chr2:55227375 C/G cg09592903 chr2:55203963 RTN4 -0.41 -10.52 -0.38 5.35e-24 Mean platelet volume; BRCA cis rs921968 0.565 rs13412324 chr2:219620521 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.06 -0.4 3.87e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs870825 0.616 rs10006828 chr4:185651416 C/T cg04058563 chr4:185651563 MLF1IP 0.79 17.79 0.58 7.74e-58 Blood protein levels; BRCA cis rs35110281 0.715 rs2838320 chr21:44995037 A/G cg21573476 chr21:45109991 RRP1B -0.36 -9.11 -0.34 1.04e-18 Mean corpuscular volume; BRCA cis rs896854 0.714 rs572547 chr8:95966286 A/G cg16049864 chr8:95962084 TP53INP1 0.48 10.56 0.39 4.05e-24 Type 2 diabetes; BRCA cis rs2239547 0.618 rs13083728 chr3:52868445 G/A cg11645453 chr3:52864694 ITIH4 0.48 11.88 0.43 1.47e-29 Schizophrenia; BRCA cis rs9811920 0.609 rs4479633 chr3:99654510 G/A cg07805332 chr3:99536008 MIR548G;C3orf26 0.36 8.22 0.31 1.16e-15 Axial length; BRCA cis rs4319547 0.697 rs7974262 chr12:122896385 C/T cg23029597 chr12:123009494 RSRC2 0.62 12.11 0.43 1.53e-30 Body mass index; BRCA cis rs10751667 0.643 rs7394524 chr11:933865 T/C ch.11.42038R chr11:967971 AP2A2 0.5 15.79 0.53 1.21e-47 Alzheimer's disease (late onset); BRCA cis rs7586673 0.893 rs889925 chr2:161971597 T/C cg21518248 chr2:162101506 NA 0.53 11.28 0.41 5.07e-27 Intelligence (multi-trait analysis); BRCA cis rs12500482 0.935 rs12644638 chr4:2413461 C/T cg08330972 chr4:2403930 ZFYVE28 -0.31 -8.3 -0.31 6.13e-16 Cognitive function; BRCA cis rs10162002 1.000 rs73449251 chr13:24042272 C/T cg00158254 chr13:24040743 NA 0.58 9.4 0.35 9.33e-20 Hypothyroidism; BRCA cis rs4689592 0.513 rs2358718 chr4:7068743 A/C cg19539972 chr4:7069911 GRPEL1 -0.7 -16.58 -0.55 1.28e-51 Monocyte percentage of white cells; BRCA trans rs8062405 0.824 rs62034326 chr16:28539293 A/G cg09719594 chr16:21412588 NA -0.34 -8.27 -0.31 7.88e-16 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs2153535 0.601 rs969420 chr6:8451966 T/A cg07606381 chr6:8435919 SLC35B3 0.65 14.29 0.49 2.19e-40 Motion sickness; BRCA cis rs9787249 0.957 rs7547787 chr1:40220806 C/T cg02773041 chr1:40204384 PPIE 0.45 9.6 0.36 1.71e-20 Blood protein levels; BRCA cis rs2625529 0.775 rs4777477 chr15:72269612 G/A cg16672083 chr15:72433130 SENP8 -0.85 -17.65 -0.57 4.2e-57 Red blood cell count; BRCA cis rs7246657 0.943 rs10414904 chr19:37830088 G/A cg23950597 chr19:37808831 NA -0.62 -11.36 -0.41 2.26e-27 Coronary artery calcification; BRCA cis rs4434138 0.683 rs13063160 chr3:52602274 T/C cg18404041 chr3:52824283 ITIH1 -0.37 -11.33 -0.41 3.04e-27 Intelligence (multi-trait analysis); BRCA cis rs2580764 0.598 rs7340476 chr2:55227346 G/C cg09592903 chr2:55203963 RTN4 -0.41 -10.52 -0.38 5.35e-24 Mean platelet volume; BRCA cis rs7618501 0.573 rs2624824 chr3:50088266 T/C cg24110177 chr3:50126178 RBM5 0.4 11.25 0.41 6.55e-27 Intelligence (multi-trait analysis); BRCA cis rs6142102 0.961 rs6057957 chr20:32549858 T/G cg24642439 chr20:33292090 TP53INP2 0.43 8.15 0.31 1.97e-15 Skin pigmentation; BRCA cis rs9443645 0.527 rs9359362 chr6:79723756 T/C cg05283184 chr6:79620031 NA -0.36 -8.23 -0.31 1.02e-15 Intelligence (multi-trait analysis); BRCA cis rs7914558 1.000 rs10786733 chr10:104794947 G/A cg04362960 chr10:104952993 NT5C2 0.42 10.1 0.37 2.41e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs7267979 1.000 rs1077889 chr20:25267893 A/G cg08601574 chr20:25228251 PYGB 0.35 8.35 0.31 4.24e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7903847 0.667 rs3818787 chr10:99145179 T/C cg08345082 chr10:99160200 RRP12 -0.28 -8.39 -0.32 3.05e-16 Granulocyte percentage of myeloid white cells; BRCA cis rs6772849 0.930 rs1962040 chr3:128324161 G/A cg16766828 chr3:128327626 NA -0.41 -8.93 -0.33 4.32e-18 Monocyte percentage of white cells;Monocyte count; BRCA cis rs77972916 0.505 rs1322 chr2:43521167 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -11.04 -0.4 4.71e-26 Granulocyte percentage of myeloid white cells; BRCA cis rs78456975 0.527 rs7590742 chr2:1575049 A/T cg26248373 chr2:1572462 NA -0.63 -14.52 -0.5 1.68e-41 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs9381040 0.631 rs13216201 chr6:41162060 G/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.44 -8.57 -0.32 8e-17 Alzheimer's disease (late onset); BRCA cis rs7582180 0.629 rs11694642 chr2:100957813 A/G cg08017756 chr2:100939284 LONRF2 -0.31 -7.99 -0.3 6.51e-15 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.701 rs3898237 chr12:38219714 A/G cg13010199 chr12:38710504 ALG10B 0.51 10.01 0.37 5.33e-22 Bladder cancer; BRCA cis rs7772486 0.875 rs2814873 chr6:146308932 T/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.59 -0.32 6.86e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs589448 0.902 rs528974 chr12:69765918 A/T cg14784868 chr12:69753453 YEATS4 0.78 25.12 0.7 2.27e-97 Cerebrospinal fluid biomarker levels; BRCA cis rs2777491 0.574 rs2730056 chr15:41735785 A/G cg18705301 chr15:41695430 NDUFAF1 -1.08 -24.99 -0.7 1.08e-96 Ulcerative colitis; BRCA cis rs13046373 0.535 rs1961491 chr21:31973685 C/T cg16812893 chr21:31813075 KRTAP15-1 0.39 9.77 0.36 4.14e-21 HDL cholesterol; BRCA cis rs67478160 0.634 rs1955660 chr14:104229985 C/T cg08213375 chr14:104286397 PPP1R13B 0.52 13.29 0.47 8.81e-36 Schizophrenia; BRCA cis rs2742234 0.590 rs2257767 chr10:43657811 T/G cg15436174 chr10:43711423 RASGEF1A -0.56 -11.35 -0.41 2.4e-27 Hirschsprung disease; BRCA cis rs2153535 0.541 rs9405386 chr6:8458067 C/G cg21535247 chr6:8435926 SLC35B3 0.39 8.89 0.33 6.32e-18 Motion sickness; BRCA cis rs9325144 0.534 rs4882350 chr12:38686979 A/G cg26384229 chr12:38710491 ALG10B 0.51 13.55 0.47 5.82e-37 Morning vs. evening chronotype; BRCA cis rs6964587 0.633 rs13231620 chr7:91507859 G/A cg17063962 chr7:91808500 NA -0.53 -11.57 -0.42 2.94e-28 Breast cancer; BRCA trans rs7980799 0.682 rs7138529 chr12:33634855 T/C cg26384229 chr12:38710491 ALG10B -0.51 -10.79 -0.39 4.88e-25 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2197308 0.626 rs6581156 chr12:37858731 C/A cg13010199 chr12:38710504 ALG10B -0.44 -9.42 -0.35 8.05e-20 Morning vs. evening chronotype; BRCA cis rs2797160 1.000 rs6904069 chr6:125995134 C/T cg05901451 chr6:126070800 HEY2 -0.39 -9.56 -0.35 2.45e-20 Endometrial cancer; BRCA cis rs965469 1.000 rs6037532 chr20:3267911 T/C cg25506879 chr20:3388711 C20orf194 -0.51 -10.23 -0.38 7.7e-23 IFN-related cytopenia; BRCA cis rs4742903 1.000 rs3780535 chr9:106894211 A/C cg14250997 chr9:106856677 SMC2 0.35 11.22 0.41 8.33e-27 High-grade serous ovarian cancer;Breast cancer; BRCA cis rs13118159 0.509 rs10023473 chr4:1375285 C/T cg05025164 chr4:1340916 KIAA1530 0.6 12.18 0.43 7.92e-31 Longevity; BRCA cis rs912057 0.609 rs1294431 chr6:6745003 G/C cg06612196 chr6:6737390 NA 0.46 10.81 0.39 4.12e-25 Waist-to-hip ratio adjusted for BMI in active individuals;Waist-to-hip ratio adjusted for body mass index;Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction); BRCA trans rs61931739 0.500 rs11053271 chr12:34545407 C/A cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA cis rs7249142 0.562 rs12980955 chr19:19283646 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.48 -11.13 -0.4 2.04e-26 IgG glycosylation; BRCA trans rs6011368 0.840 rs2427638 chr20:62900717 C/T cg13869341 chr1:15865 WASH5P 0.45 10.12 0.37 1.91e-22 Clozapine-induced cytotoxicity; BRCA cis rs6893300 0.506 rs35320050 chr5:179131013 C/T cg14593053 chr5:179126677 CANX 0.48 12.91 0.45 4.59e-34 Resting heart rate; BRCA cis rs10504229 0.683 rs7843919 chr8:58130792 T/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs10540 1.000 rs35068485 chr11:466032 A/T cg15790184 chr11:494944 RNH1 0.64 9.95 0.37 8.42e-22 Body mass index; BRCA cis rs9649213 0.555 rs12667634 chr7:97965442 A/G cg01877450 chr7:97915802 BRI3 -0.38 -8.75 -0.33 1.94e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs1552244 0.572 rs7645667 chr3:10157337 C/A cg16606324 chr3:10149918 C3orf24 0.58 10.08 0.37 2.93e-22 Alzheimer's disease; BRCA cis rs897080 0.515 rs1067357 chr2:44663064 G/T cg18685995 chr2:44588913 PREPL;C2orf34 0.51 9.15 0.34 7.72e-19 Height; BRCA cis rs7520050 0.966 rs785488 chr1:46576095 G/A cg24296786 chr1:45957014 TESK2 0.41 9.12 0.34 9.96e-19 Red blood cell count;Reticulocyte count; BRCA cis rs2742234 0.541 rs1254959 chr10:43700979 C/G cg15436174 chr10:43711423 RASGEF1A 0.57 11.53 0.41 4.62e-28 Hirschsprung disease; BRCA cis rs9942416 0.660 rs10462356 chr5:74987108 C/T cg19683494 chr5:74908142 NA 0.48 9.0 0.34 2.66e-18 Age-related disease endophenotypes; BRCA cis rs1568889 0.838 rs1525717 chr11:28081205 T/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.46 0.63 6.26e-72 Bipolar disorder; BRCA cis rs7772486 0.686 rs1004752 chr6:146037822 G/A cg23711669 chr6:146136114 FBXO30 -0.71 -16.94 -0.56 2e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs9527 0.535 rs4917999 chr10:104963051 C/G cg04362960 chr10:104952993 NT5C2 -0.43 -9.69 -0.36 8.33e-21 Arsenic metabolism; BRCA cis rs6565681 1.000 rs4889848 chr17:78354661 C/T cg15383979 chr17:78362278 RNF213;LOC100294362 -0.5 -8.39 -0.32 3.1e-16 Moyamoya disease; BRCA cis rs10256972 0.591 rs6968988 chr7:1169619 A/G cg23708337 chr7:1209742 NA 0.53 10.66 0.39 1.58e-24 Longevity;Endometriosis; BRCA cis rs8031584 0.672 rs17815726 chr15:31313252 C/G cg08109568 chr15:31115862 NA 0.44 8.83 0.33 1.04e-17 Huntington's disease progression; BRCA cis rs6424115 0.708 rs12748109 chr1:24181177 C/T cg08896387 chr1:24191740 FUCA1 -0.24 -7.9 -0.3 1.21e-14 Immature fraction of reticulocytes; BRCA trans rs6582630 0.555 rs11182422 chr12:38522833 A/G cg06521331 chr12:34319734 NA -0.44 -8.58 -0.32 7.23e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs8141529 0.748 rs9620841 chr22:29290981 C/T cg15103426 chr22:29168792 CCDC117 0.52 12.04 0.43 3.24e-30 Lymphocyte counts; BRCA cis rs12477438 0.520 rs11677247 chr2:99756358 A/G cg14399236 chr2:99771627 LIPT1;TSGA10 0.81 22.74 0.67 2.6e-84 Chronic sinus infection; BRCA trans rs6461049 0.646 rs3778970 chr7:2143208 C/A cg04565464 chr8:145669602 NFKBIL2 0.43 9.56 0.35 2.53e-20 Schizophrenia; BRCA cis rs2836633 0.895 rs991816 chr21:40042150 C/A cg05519781 chr21:40033154 ERG 0.37 7.89 0.3 1.33e-14 Coronary artery disease; BRCA cis rs6005807 0.582 rs8136767 chr22:29008626 G/A cg12565055 chr22:29076175 TTC28 0.5 9.41 0.35 8.9e-20 Cerebrospinal T-tau levels;Epithelial ovarian cancer;Cerebrospinal fluid p-Tau181p:AB1-42 ratio;Cerebrospinal P-tau181p levels;Serous invasive ovarian cancer;High-grade serous ovarian cancer;Invasive epithelial ovarian cancer; BRCA cis rs6545883 0.860 rs4671399 chr2:61458518 C/T cg15711740 chr2:61764176 XPO1 0.51 13.06 0.46 1.06e-34 Tuberculosis; BRCA trans rs800082 0.839 rs62275528 chr3:144293687 T/C cg24215973 chr2:240111563 HDAC4 -0.35 -7.82 -0.3 2.18e-14 Smoking behavior; BRCA trans rs7200543 1.000 rs4985154 chr16:15131642 G/C cg24683922 chr1:11983373 KIAA2013 -0.39 -8.71 -0.33 2.69e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA cis rs9790314 0.846 rs4560315 chr3:160982132 G/T cg03342759 chr3:160939853 NMD3 -0.72 -17.97 -0.58 9.09e-59 Morning vs. evening chronotype; BRCA cis rs2050392 0.624 rs303449 chr10:30726845 G/A cg18806716 chr10:30721971 MAP3K8 -0.56 -13.43 -0.47 2.21e-36 Inflammatory bowel disease; BRCA cis rs1552244 0.572 rs3843008 chr3:10173742 C/T cg08888203 chr3:10149979 C3orf24 0.55 8.64 0.32 4.65e-17 Alzheimer's disease; BRCA cis rs2836950 0.545 rs8132424 chr21:40584412 A/T cg17971929 chr21:40555470 PSMG1 0.5 11.25 0.41 6.35e-27 Menarche (age at onset); BRCA cis rs10504229 0.639 rs67996345 chr8:58117127 A/G cg20607798 chr8:58055168 NA 0.48 8.43 0.32 2.29e-16 Developmental language disorder (linguistic errors); BRCA cis rs17253792 0.822 rs79022053 chr14:56071721 A/G cg01858014 chr14:56050164 KTN1 -0.78 -11.08 -0.4 3.12e-26 Putamen volume; BRCA trans rs9858542 0.953 rs34588335 chr3:49407660 G/C cg21659725 chr3:3221576 CRBN -0.45 -10.01 -0.37 5.41e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs7258465 1.000 rs10403249 chr19:18604942 T/C cg01065977 chr19:18549689 ISYNA1 -0.28 -8.35 -0.31 4.25e-16 Breast cancer; BRCA cis rs1862618 0.853 rs832578 chr5:56164223 C/T cg18230493 chr5:56204884 C5orf35 -0.73 -14.68 -0.5 2.87e-42 Initial pursuit acceleration; BRCA trans rs7829975 0.688 rs7827182 chr8:8380471 C/G cg21775007 chr8:11205619 TDH 0.41 8.45 0.32 2e-16 Mood instability; BRCA trans rs9329221 0.736 rs34381075 chr8:10243785 C/G cg15556689 chr8:8085844 FLJ10661 0.36 8.68 0.32 3.29e-17 Neuroticism; BRCA cis rs5167 0.504 rs3760627 chr19:45457180 T/C cg20090143 chr19:45452003 APOC2 0.27 8.08 0.3 3.25e-15 Blood protein levels; BRCA cis rs12142240 0.698 rs17413694 chr1:46818416 A/C cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs4642101 0.662 rs57411588 chr3:12820384 C/G cg05775895 chr3:12838266 CAND2 0.37 8.33 0.31 4.79e-16 QRS complex (12-leadsum); BRCA cis rs4363385 0.720 rs1611754 chr1:152956415 A/T cg25856811 chr1:152973957 SPRR3 -0.33 -8.88 -0.33 6.88e-18 Inflammatory skin disease; BRCA cis rs17685 0.753 rs10264760 chr7:75749694 A/G cg16489192 chr7:75678113 MDH2;STYXL1 -0.42 -9.76 -0.36 4.63e-21 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs9311474 0.629 rs4282054 chr3:52566065 T/C cg10712668 chr3:52740153 GLT8D1;SPCS1 0.36 7.83 0.3 1.98e-14 Electroencephalogram traits; BRCA cis rs908922 0.676 rs7550769 chr1:152531213 G/A cg20991723 chr1:152506922 NA 0.36 8.13 0.31 2.24e-15 Hair morphology; BRCA cis rs701145 0.585 rs357468 chr3:153898560 A/G cg17054900 chr3:154042577 DHX36 0.53 9.34 0.35 1.62e-19 Coronary artery disease; BRCA cis rs7772486 0.790 rs2256998 chr6:146207657 A/C cg13319975 chr6:146136371 FBXO30 -0.41 -9.38 -0.35 1.12e-19 Lobe attachment (rater-scored or self-reported); BRCA cis rs1348850 0.574 rs11889488 chr2:178426793 A/G cg27490568 chr2:178487706 NA -0.57 -9.23 -0.34 3.99e-19 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA trans rs61931739 0.500 rs34167298 chr12:34534338 G/A cg26384229 chr12:38710491 ALG10B 0.75 16.65 0.55 6.01e-52 Morning vs. evening chronotype; BRCA trans rs3960554 0.741 rs28446604 chr7:75662518 C/T cg19862616 chr7:65841803 NCRNA00174 0.58 12.21 0.43 6.03e-31 Eotaxin levels; BRCA cis rs4648845 0.777 rs2477686 chr1:2392648 C/G cg11214544 chr1:2391121 NA -0.35 -8.53 -0.32 1.05e-16 Schizophrenia; BRCA cis rs11792861 0.591 rs2282206 chr9:111746267 A/G cg14432460 chr9:111696404 IKBKAP;C9orf6 0.59 12.9 0.45 5.17e-34 Menarche (age at onset); BRCA cis rs367943 0.637 rs6859521 chr5:113007423 C/T cg12552261 chr5:112820674 MCC 0.39 7.87 0.3 1.49e-14 Type 2 diabetes; BRCA cis rs9814567 1.000 rs4955555 chr3:134286427 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.58 -0.61 3.27e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs35306767 0.715 rs17293580 chr10:1034895 T/C cg18964960 chr10:1102726 WDR37 0.6 8.36 0.31 3.84e-16 Eosinophil percentage of granulocytes; BRCA trans rs35110281 0.837 rs2838342 chr21:45077865 G/A cg18724061 chr6:27861294 HIST1H2AM;HIST1H2BO 0.38 8.07 0.3 3.48e-15 Mean corpuscular volume; BRCA cis rs10876993 0.890 rs1678516 chr12:58047458 G/A cg00677455 chr12:58241039 CTDSP2 -0.35 -7.9 -0.3 1.24e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs992157 0.710 rs13026485 chr2:219057984 C/T cg00012203 chr2:219082015 ARPC2 -0.7 -15.98 -0.53 1.29e-48 Colorectal cancer; BRCA cis rs9649213 0.613 rs7777415 chr7:97959214 A/T cg21770322 chr7:97807741 LMTK2 0.45 11.81 0.42 2.94e-29 Prostate cancer (SNP x SNP interaction); BRCA trans rs17685 0.753 rs2302438 chr7:75677065 C/A cg19862616 chr7:65841803 NCRNA00174 0.83 27.23 0.73 5.66e-109 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs17270561 0.779 rs12210620 chr6:25884785 T/C cg17691542 chr6:26056736 HIST1H1C 0.74 14.71 0.5 2.08e-42 Iron status biomarkers; BRCA cis rs57221529 0.766 rs12518859 chr5:587432 C/T cg20362242 chr5:692897 TPPP 0.53 7.97 0.3 7.21e-15 Lung disease severity in cystic fibrosis; BRCA cis rs35306767 0.715 rs12772979 chr10:1034412 C/T cg18964960 chr10:1102726 WDR37 0.62 8.38 0.31 3.32e-16 Eosinophil percentage of granulocytes; BRCA cis rs13191362 0.935 rs4273664 chr6:162955494 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.85 12.47 0.44 4.18e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10504229 0.683 rs11786527 chr8:58131344 G/C cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs2303759 0.914 rs2288481 chr19:49878196 G/A cg22307029 chr19:49891270 CCDC155 0.58 9.35 0.35 1.45e-19 Multiple sclerosis; BRCA cis rs79976124 0.842 rs7760550 chr6:66628788 T/C cg07460842 chr6:66804631 NA 0.62 11.18 0.4 1.27e-26 Type 2 diabetes; BRCA cis rs897984 0.762 rs2305880 chr16:30999462 T/C cg00531865 chr16:30841666 NA 0.39 9.28 0.34 2.6e-19 Dementia with Lewy bodies; BRCA cis rs7833986 0.501 rs72653986 chr8:57035048 T/C cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.81 0.45 1.37e-33 Height; BRCA cis rs7917772 0.536 rs17783771 chr10:104410736 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.63 15.64 0.53 6.08e-47 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs898097 0.625 rs2125479 chr17:80890262 A/G cg15664640 chr17:80829946 TBCD -0.4 -10.33 -0.38 3.21e-23 Breast cancer; BRCA cis rs6426558 0.537 rs2670462 chr1:227432923 C/G cg10327440 chr1:227177885 CDC42BPA -0.43 -8.91 -0.33 5.33e-18 Neutrophil percentage of white cells; BRCA cis rs7618501 0.602 rs9311446 chr3:50092226 G/A cg24110177 chr3:50126178 RBM5 0.35 9.65 0.36 1.19e-20 Intelligence (multi-trait analysis); BRCA cis rs4975616 0.869 rs452932 chr5:1330253 T/C cg26373071 chr5:1325741 CLPTM1L 0.5 12.35 0.44 1.36e-31 Lung cancer; BRCA cis rs2370759 1.000 rs11594459 chr10:32561858 A/C cg01819863 chr10:32635814 EPC1 1.17 20.65 0.63 5.58e-73 Sexual dysfunction (female); BRCA cis rs1904096 0.506 rs2632412 chr4:95149319 A/C cg11021082 chr4:95130006 SMARCAD1 0.41 8.48 0.32 1.51e-16 Type 2 diabetes; BRCA cis rs941873 0.868 rs10740497 chr10:81126380 T/C cg08514558 chr10:81106712 PPIF 0.4 9.36 0.35 1.38e-19 Height; BRCA cis rs2404602 0.647 rs10152247 chr15:76942252 T/G cg23625390 chr15:77176239 SCAPER -0.56 -14.23 -0.49 4.3e-40 Blood metabolite levels; BRCA cis rs7267979 0.903 rs2500400 chr20:25354705 A/G cg08601574 chr20:25228251 PYGB -0.37 -8.82 -0.33 1.08e-17 Liver enzyme levels (alkaline phosphatase); BRCA cis rs35110281 0.837 rs2838343 chr21:45078035 C/T cg01579765 chr21:45077557 HSF2BP -0.42 -11.53 -0.42 4.34e-28 Mean corpuscular volume; BRCA trans rs6089829 0.925 rs6062396 chr20:61667949 T/C cg23505145 chr19:12996616 KLF1 0.54 12.3 0.44 2.43e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs8058578 1.000 rs8048448 chr16:30692208 T/C cg00531865 chr16:30841666 NA -0.57 -13.24 -0.46 1.58e-35 Multiple myeloma; BRCA cis rs11779988 0.545 rs422746 chr8:17784486 C/A cg01800426 chr8:17659068 MTUS1 -0.4 -8.36 -0.31 4.03e-16 Breast cancer; BRCA cis rs8177253 0.965 rs8177245 chr3:133479230 A/G cg08048268 chr3:133502702 NA -0.33 -8.35 -0.31 4.32e-16 Iron status biomarkers; BRCA trans rs12310956 0.532 rs10844707 chr12:33936089 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.57 0.35 2.24e-20 Morning vs. evening chronotype; BRCA cis rs6121246 0.909 rs6060979 chr20:30417522 C/T cg13852791 chr20:30311386 BCL2L1 0.75 14.06 0.49 2.67e-39 Mean corpuscular hemoglobin; BRCA cis rs6964587 1.000 rs12530646 chr7:91588036 A/G cg17063962 chr7:91808500 NA -0.52 -12.4 -0.44 9e-32 Breast cancer; BRCA cis rs360798 0.512 rs12989754 chr2:63020970 A/G cg17519650 chr2:63277830 OTX1 -0.37 -8.06 -0.3 3.72e-15 Coronary artery disease; BRCA cis rs10504229 0.775 rs17804840 chr8:58157045 C/T cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs9815354 0.812 rs17218441 chr3:41987044 A/G cg03022575 chr3:42003672 ULK4 0.7 9.76 0.36 4.45e-21 Pulse pressure;Diastolic blood pressure; BRCA cis rs921968 0.591 rs3731877 chr2:219602499 G/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.04 -0.4 4.59e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs57590327 0.555 rs3821551 chr3:81710179 A/T cg07356753 chr3:81810745 GBE1 -0.44 -10.0 -0.37 5.8e-22 Extraversion; BRCA cis rs208520 0.802 rs4710315 chr6:66887594 A/G cg07460842 chr6:66804631 NA -0.95 -17.64 -0.57 4.66e-57 Exhaled nitric oxide output; BRCA cis rs9914544 0.966 rs1737943 chr17:18841590 A/G cg26306683 chr17:18585705 ZNF286B -0.32 -8.26 -0.31 8.28e-16 Educational attainment (years of education); BRCA cis rs2075371 0.829 rs9641970 chr7:134004887 C/A cg20476274 chr7:133979776 SLC35B4 0.61 15.05 0.51 5.07e-44 Mean platelet volume; BRCA cis rs72928364 1.000 rs67946790 chr3:100688682 T/A cg10123952 chr3:100791384 NA 0.53 7.89 0.3 1.3e-14 Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes; BRCA cis rs12410462 0.892 rs35341041 chr1:227653885 G/A cg23173402 chr1:227635558 NA 0.54 9.7 0.36 7.72e-21 Major depressive disorder; BRCA cis rs873946 0.648 rs35417213 chr10:134553749 A/G cg13271783 chr10:134563150 INPP5A -0.5 -9.52 -0.35 3.56e-20 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA trans rs2262909 0.962 rs390730 chr19:22233509 C/A cg17074339 chr11:11642133 GALNTL4 -0.41 -8.02 -0.3 4.97e-15 Chagas cardiomyopathy in Tripanosoma cruzi seropositivity; BRCA cis rs4808199 0.948 rs1859287 chr19:19422187 T/C cg03709012 chr19:19516395 GATAD2A 0.9 17.31 0.57 2.34e-55 Nonalcoholic fatty liver disease; BRCA cis rs514406 0.708 rs546334 chr1:53326210 T/C cg16325326 chr1:53192061 ZYG11B 0.58 12.72 0.45 3.3e-33 Monocyte count; BRCA cis rs12579753 0.789 rs1343933 chr12:82123301 A/C cg07988820 chr12:82153109 PPFIA2 -0.69 -11.62 -0.42 1.98e-28 Resting heart rate; BRCA cis rs873946 0.618 rs12775767 chr10:134545628 C/T cg13271783 chr10:134563150 INPP5A -0.5 -9.31 -0.35 1.98e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs8072100 0.582 rs3826536 chr17:45501967 T/A cg25173405 chr17:45401733 C17orf57 -0.51 -10.59 -0.39 2.89e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1552244 0.882 rs13088350 chr3:10044626 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.85 17.01 0.56 8.75e-54 Alzheimer's disease; BRCA trans rs6089829 0.890 rs6062775 chr20:61663650 T/C cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA trans rs61931739 0.500 rs7309931 chr12:34483471 A/C cg26384229 chr12:38710491 ALG10B 0.58 13.39 0.47 3.21e-36 Morning vs. evening chronotype; BRCA cis rs10504229 1.000 rs57261109 chr8:58172152 C/T cg24829409 chr8:58192753 C8orf71 -0.6 -12.55 -0.44 1.86e-32 Developmental language disorder (linguistic errors); BRCA cis rs9868809 0.881 rs2286652 chr3:48689192 G/A cg00383909 chr3:49044727 WDR6 0.62 10.12 0.37 1.92e-22 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2075371 1.000 rs2244700 chr7:133987374 A/G cg20476274 chr7:133979776 SLC35B4 0.62 17.99 0.58 7.18e-59 Mean platelet volume; BRCA trans rs1941687 0.527 rs2000945 chr18:31365336 A/G cg15819921 chr19:927150 ARID3A -0.48 -9.38 -0.35 1.18e-19 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs1401999 1.000 rs6800217 chr3:183685893 T/C cg01324343 chr3:183735012 ABCC5 0.83 20.95 0.64 1.44e-74 Anterior chamber depth; BRCA cis rs7100689 0.784 rs10749562 chr10:82108253 G/T cg01528321 chr10:82214614 TSPAN14 0.92 20.17 0.62 2.1e-70 Post bronchodilator FEV1; BRCA cis rs7647973 0.710 rs2029591 chr3:49646981 C/T cg03060546 chr3:49711283 APEH -0.53 -8.88 -0.33 6.58e-18 Menarche (age at onset); BRCA cis rs4919087 0.923 rs11189038 chr10:98974765 A/T cg25902810 chr10:99078978 FRAT1 0.43 8.8 0.33 1.26e-17 Monocyte count; BRCA cis rs9467773 1.000 rs9461271 chr6:26554968 G/A cg11502198 chr6:26597334 ABT1 0.48 9.67 0.36 9.58e-21 Intelligence (multi-trait analysis); BRCA trans rs7980799 0.649 rs12819439 chr12:33684509 A/C cg26384229 chr12:38710491 ALG10B 0.52 10.98 0.4 8.47e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs6121246 0.542 rs2376990 chr20:30238744 G/A cg21427119 chr20:30132790 HM13 -0.43 -8.81 -0.33 1.22e-17 Mean corpuscular hemoglobin; BRCA cis rs7493 0.806 rs17876090 chr7:95053404 A/T cg17330251 chr7:94953956 PON1 -0.42 -8.58 -0.32 7.37e-17 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs4925325 0.955 rs1776262 chr20:60516023 G/T cg13770153 chr20:60521292 NA 0.84 22.16 0.66 3.49e-81 Obesity-related traits; BRCA cis rs7737355 1.000 rs248652 chr5:130654837 A/T cg06307176 chr5:131281290 NA -0.46 -8.98 -0.33 2.98e-18 Life satisfaction; BRCA cis rs939658 0.805 rs11634903 chr15:79436192 C/T cg17916960 chr15:79447300 NA 0.43 10.62 0.39 2.2e-24 Refractive error; BRCA cis rs8180040 0.701 rs7617689 chr3:46996442 C/T cg02527881 chr3:46936655 PTH1R 0.34 8.54 0.32 1.01e-16 Colorectal cancer; BRCA trans rs2197308 0.626 rs6581156 chr12:37858731 C/A cg06521331 chr12:34319734 NA 0.48 9.37 0.35 1.27e-19 Morning vs. evening chronotype; BRCA cis rs7249142 0.526 rs7256811 chr19:19283551 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.27 -0.41 5.36e-27 IgG glycosylation; BRCA trans rs867371 0.502 rs28610286 chr15:82525655 C/T cg04831495 chr15:85060580 GOLGA6L5 -0.32 -8.58 -0.32 7.37e-17 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs17270561 0.609 rs9379788 chr6:25742759 A/C cg16482183 chr6:26056742 HIST1H1C 0.45 8.77 0.33 1.6e-17 Iron status biomarkers; BRCA trans rs11098499 0.657 rs71614442 chr4:120379346 C/T cg25517755 chr10:38738941 LOC399744 -0.38 -7.94 -0.3 9.1e-15 Corneal astigmatism; BRCA cis rs9381040 1.000 rs9381040 chr6:41154650 C/T cg04346459 chr6:41068666 NFYA;LOC221442 -0.4 -8.35 -0.31 4.3e-16 Alzheimer's disease (late onset); BRCA cis rs4595586 0.545 rs7967931 chr12:39375162 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.59e-19 Morning vs. evening chronotype; BRCA cis rs2439831 0.850 rs16977798 chr15:44151948 C/T cg02155558 chr15:43621948 ADAL;LCMT2 0.73 13.12 0.46 5.29e-35 Lung cancer in ever smokers; BRCA cis rs12310956 0.532 rs11052948 chr12:33981973 T/C cg06521331 chr12:34319734 NA -0.61 -11.1 -0.4 2.65e-26 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs12153501 chr5:93360866 T/G cg25358565 chr5:93447407 FAM172A 1.14 18.59 0.59 5.23e-62 Diabetic retinopathy; BRCA cis rs919433 0.679 rs61155920 chr2:198528881 C/T cg00792783 chr2:198669748 PLCL1 0.39 9.03 0.34 2.08e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs4319547 0.695 rs1803290 chr12:122865029 T/C cg23029597 chr12:123009494 RSRC2 0.58 11.43 0.41 1.2100000000000001e-27 Body mass index; BRCA cis rs10751667 0.666 rs10902243 chr11:949900 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.62 0.55 8.2e-52 Alzheimer's disease (late onset); BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg16606324 chr3:10149918 C3orf24 0.45 8.0 0.3 5.81e-15 Alzheimer's disease; BRCA cis rs12347191 0.500 rs1912998 chr9:100621386 T/C cg13688889 chr9:100608707 NA -0.49 -9.96 -0.37 8.33e-22 Orofacial clefts; BRCA cis rs9790314 0.663 rs778642 chr3:160705819 A/G cg03342759 chr3:160939853 NMD3 -0.46 -8.96 -0.33 3.52e-18 Morning vs. evening chronotype; BRCA trans rs7395662 0.571 rs4882020 chr11:48615658 C/T cg15704280 chr7:45808275 SEPT13 -0.49 -9.64 -0.36 1.29e-20 HDL cholesterol; BRCA cis rs56104184 0.775 rs117744769 chr19:49402686 G/T cg15549821 chr19:49342101 PLEKHA4 -0.66 -9.58 -0.35 2.1e-20 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg21782813 chr7:2030301 MAD1L1 0.39 11.38 0.41 1.91e-27 Bipolar disorder and schizophrenia; BRCA cis rs867371 1.000 rs13380317 chr15:82506790 A/G cg00614314 chr15:82944287 LOC80154 -0.41 -8.8 -0.33 1.22e-17 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs7829975 0.567 rs6601273 chr8:8796519 T/G cg06636001 chr8:8085503 FLJ10661 -0.54 -11.76 -0.42 4.64e-29 Mood instability; BRCA cis rs4363385 0.791 rs11205177 chr1:153002502 G/A cg24667326 chr1:152973720 SPRR3 -0.32 -8.82 -0.33 1.08e-17 Inflammatory skin disease; BRCA cis rs1538970 1.000 rs9326141 chr1:45828943 A/G cg05343316 chr1:45956843 TESK2 -0.56 -11.45 -0.41 9.91e-28 Platelet count; BRCA cis rs10479542 0.721 rs6894113 chr5:178974789 G/C cg14820908 chr5:178986412 RUFY1 0.38 9.41 0.35 8.87e-20 Lung cancer; BRCA cis rs2404602 0.552 rs11636612 chr15:76959530 C/T cg23625390 chr15:77176239 SCAPER -0.54 -11.2 -0.41 1.05e-26 Blood metabolite levels; BRCA cis rs2576037 0.526 rs2010834 chr18:44560875 C/A cg19077165 chr18:44547161 KATNAL2 0.55 12.19 0.43 6.77e-31 Personality dimensions; BRCA cis rs709400 0.628 rs7146506 chr14:103924477 A/G cg24130564 chr14:104152367 KLC1 -0.34 -7.87 -0.3 1.47e-14 Body mass index; BRCA cis rs2762353 0.776 rs1165190 chr6:25848019 A/G cg03517284 chr6:25882590 NA -0.52 -11.8 -0.42 3.32e-29 Blood metabolite levels; BRCA cis rs11758351 1.000 rs17598927 chr6:26184640 C/G cg01420254 chr6:26195488 NA -0.55 -8.07 -0.3 3.46e-15 Gout;Renal underexcretion gout; BRCA cis rs13102973 0.899 rs13126625 chr4:135900322 C/T cg14419869 chr4:135874104 NA 0.47 9.48 0.35 4.96e-20 Subjective well-being; BRCA cis rs13256369 0.802 rs12681326 chr8:8566389 G/A cg06671706 chr8:8559999 CLDN23 0.43 8.29 0.31 6.45e-16 Obesity-related traits; BRCA cis rs1005277 0.540 rs4934907 chr10:38015230 A/C cg00409905 chr10:38381863 ZNF37A -0.48 -10.16 -0.37 1.38e-22 Extrinsic epigenetic age acceleration; BRCA cis rs4919694 1.000 rs12245779 chr10:104645944 C/A cg04362960 chr10:104952993 NT5C2 0.95 14.86 0.51 4.07e-43 Arsenic metabolism; BRCA cis rs11098499 0.697 rs10016448 chr4:120298845 A/G cg09307838 chr4:120376055 NA 0.73 16.02 0.54 7.93e-49 Corneal astigmatism; BRCA trans rs6582630 0.555 rs10880611 chr12:38509316 C/G cg06521331 chr12:34319734 NA -0.47 -8.73 -0.33 2.14e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs6582630 0.560 rs11504462 chr12:38440379 G/A cg26384229 chr12:38710491 ALG10B -0.43 -9.95 -0.37 9.06e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs9921192 1.000 rs2892165 chr16:4324293 A/T cg07945448 chr16:4304224 NA 0.49 10.12 0.37 1.92e-22 Prostate-specific antigen levels; BRCA cis rs7264396 0.528 rs6058370 chr20:34518592 C/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.67 -12.78 -0.45 1.75e-33 Total cholesterol levels; BRCA cis rs7918232 0.830 rs10764672 chr10:27392541 A/C cg14442939 chr10:27389572 ANKRD26 -0.7 -12.82 -0.45 1.24e-33 Breast cancer; BRCA trans rs61931739 0.500 rs11053194 chr12:34440841 A/G cg26384229 chr12:38710491 ALG10B 0.57 13.08 0.46 8.05e-35 Morning vs. evening chronotype; BRCA trans rs11098499 0.863 rs7695620 chr4:120452776 G/A cg25214090 chr10:38739885 LOC399744 0.56 12.39 0.44 9.8e-32 Corneal astigmatism; BRCA cis rs9834373 0.553 rs12491264 chr3:78497118 T/C cg06138941 chr3:78371609 NA -0.35 -8.54 -0.32 9.73e-17 Protein quantitative trait loci; BRCA cis rs72781680 0.904 rs72796340 chr2:24143622 T/A cg08917208 chr2:24149416 ATAD2B 0.94 14.07 0.49 2.42e-39 Lymphocyte counts; BRCA cis rs7914558 0.966 rs4917997 chr10:104945213 A/G cg04362960 chr10:104952993 NT5C2 0.43 10.24 0.38 6.79e-23 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs765787 0.530 rs28815867 chr15:45526805 G/C cg24006582 chr15:45444508 DUOX1 -0.53 -10.92 -0.4 1.44e-25 Uric acid levels; BRCA cis rs6820391 0.781 rs1369354 chr4:54447974 G/T cg04173182 chr4:54446035 LNX1 0.51 11.57 0.42 3.2e-28 Cervical artery dissection; BRCA cis rs600231 0.542 rs34527830 chr11:65240863 G/A cg01292856 chr11:65242576 NA 0.65 14.83 0.51 5.53e-43 Bone mineral density; BRCA cis rs2749592 0.531 rs994804 chr10:37900140 A/C cg00409905 chr10:38381863 ZNF37A 0.46 9.45 0.35 6.04e-20 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10464366 0.746 rs11760807 chr7:39142377 G/A cg15212455 chr7:39170539 POU6F2 0.38 8.52 0.32 1.14e-16 IgG glycosylation; BRCA cis rs2625529 0.617 rs3784313 chr15:72187519 G/T cg16672083 chr15:72433130 SENP8 0.66 15.74 0.53 2.07e-47 Red blood cell count; BRCA cis rs5750830 0.594 rs5757650 chr22:39778419 A/G cg05872129 chr22:39784769 NA -0.45 -9.97 -0.37 7.67e-22 Intelligence (multi-trait analysis); BRCA cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg05535760 chr7:792225 HEATR2 0.72 13.22 0.46 1.82e-35 Cerebrospinal P-tau181p levels; BRCA cis rs10493773 1.000 rs10493773 chr1:86125753 C/T cg17807903 chr1:86174739 ZNHIT6 0.46 9.46 0.35 5.94e-20 Urate levels in overweight individuals; BRCA cis rs12887734 0.546 rs66676135 chr14:104271504 G/A cg26031613 chr14:104095156 KLC1 -0.54 -9.44 -0.35 6.92e-20 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs4689388 0.853 rs13108780 chr4:6294630 A/G cg25554036 chr4:6271136 WFS1 0.42 9.99 0.37 6.36e-22 Type 2 diabetes and other traits;Type 2 diabetes; BRCA cis rs7618915 0.547 rs62255371 chr3:52747321 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.92 0.4 1.44e-25 Bipolar disorder; BRCA cis rs9790314 1.000 rs6775627 chr3:160953609 A/G cg04691961 chr3:161091175 C3orf57 -0.59 -14.06 -0.49 2.44e-39 Morning vs. evening chronotype; BRCA cis rs4285028 0.747 rs12634032 chr3:121524575 G/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.9 -16.34 -0.54 1.98e-50 Multiple sclerosis; BRCA cis rs10504229 0.600 rs6987243 chr8:58115406 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.9 -0.33 5.94e-18 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.590 rs6716858 chr2:26423414 G/A cg08470875 chr2:26401718 FAM59B -0.62 -10.53 -0.38 4.96e-24 Gut microbiome composition (summer); BRCA trans rs61931739 0.500 rs7313094 chr12:34457508 T/C cg26384229 chr12:38710491 ALG10B 0.58 13.26 0.46 1.22e-35 Morning vs. evening chronotype; BRCA cis rs8114671 0.570 rs3761144 chr20:33544075 C/G cg24642439 chr20:33292090 TP53INP2 0.43 8.86 0.33 8.02e-18 Height; BRCA cis rs240110 0.539 rs6919745 chr6:101338978 T/C cg09795085 chr6:101329169 ASCC3 0.39 8.08 0.3 3.32e-15 Neuroticism; BRCA cis rs9291683 0.551 rs2240720 chr4:10020480 C/T cg02734326 chr4:10020555 SLC2A9 0.41 8.92 0.33 4.71e-18 Bone mineral density; BRCA trans rs2749592 0.513 rs1208708 chr10:38085576 A/G cg17830980 chr10:43048298 ZNF37B -0.37 -7.84 -0.3 1.94e-14 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs7833790 0.963 rs6473312 chr8:82732515 C/A cg17211192 chr8:82754475 SNX16 -0.6 -11.54 -0.42 4.05e-28 Diastolic blood pressure; BRCA cis rs12612619 0.732 rs1440044 chr2:27226954 A/G cg00617064 chr2:27272375 NA -0.31 -8.06 -0.3 3.74e-15 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs11718455 0.767 rs4682924 chr3:43992760 G/A cg08738300 chr3:44038990 NA 0.48 8.87 0.33 7.13e-18 Coronary artery disease; BRCA cis rs2992756 0.663 rs3007734 chr1:18803022 T/C cg14356550 chr1:18808102 KLHDC7A -0.38 -7.81 -0.3 2.28e-14 Breast cancer; BRCA cis rs4925325 0.741 rs6142886 chr20:60511190 A/G cg16423285 chr20:60520624 NA 0.61 13.2 0.46 2.44e-35 Obesity-related traits; BRCA cis rs7615952 0.599 rs12496921 chr3:125701948 C/G cg18479299 chr3:125709523 NA -0.54 -8.46 -0.32 1.84e-16 Blood pressure (smoking interaction); BRCA cis rs1552244 0.515 rs67626468 chr3:10161518 C/A cg00149659 chr3:10157352 C3orf10 1.08 18.11 0.58 1.73e-59 Alzheimer's disease; BRCA trans rs6582630 0.537 rs2204006 chr12:38407098 A/G cg06521331 chr12:34319734 NA -0.45 -8.4 -0.32 2.92e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs17818399 0.653 rs34050156 chr2:46777646 A/G cg02822958 chr2:46747628 ATP6V1E2 0.57 10.57 0.39 3.59e-24 Height; BRCA cis rs6138458 1.000 rs6114988 chr20:24977586 C/T cg06937882 chr20:24974362 C20orf3 -0.48 -9.47 -0.35 5.48e-20 Blood protein levels; BRCA cis rs10504229 1.000 rs67243305 chr8:58174958 G/A cg14926445 chr8:58193284 C8orf71 -0.45 -8.58 -0.32 6.92e-17 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1328862 chr6:8526681 A/T cg07606381 chr6:8435919 SLC35B3 0.65 14.22 0.49 4.65e-40 Motion sickness; BRCA cis rs7584330 0.554 rs77194105 chr2:238436463 T/C cg08992911 chr2:238395768 MLPH 0.54 8.34 0.31 4.44e-16 Prostate cancer; BRCA cis rs4727027 0.704 rs7784122 chr7:148904624 A/G cg23583168 chr7:148888333 NA 0.95 24.48 0.7 7.11e-94 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs7727544 0.636 rs2631365 chr5:131705949 T/C cg07395648 chr5:131743802 NA 0.38 9.42 0.35 8.26e-20 Blood metabolite levels; BRCA cis rs12477438 0.520 rs13010904 chr2:99754289 G/A cg26064155 chr2:99771622 LIPT1;TSGA10 0.9 30.18 0.77 5e-125 Chronic sinus infection; BRCA cis rs757081 0.667 rs644419 chr11:17212375 C/T cg15432903 chr11:17409602 KCNJ11 0.45 8.5 0.32 1.32e-16 Systolic blood pressure; BRCA cis rs6570726 0.935 rs12663205 chr6:145818378 G/A cg23711669 chr6:146136114 FBXO30 0.64 15.08 0.51 3.35e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs911555 0.723 rs56227024 chr14:103861706 A/G cg12935359 chr14:103987150 CKB 0.58 13.31 0.47 7.29e-36 Intelligence (multi-trait analysis); BRCA cis rs6088580 0.634 rs6119497 chr20:33012529 T/A cg06115741 chr20:33292138 TP53INP2 0.39 8.68 0.32 3.35e-17 Glomerular filtration rate (creatinine); BRCA cis rs250677 1.000 rs36082 chr5:148428844 C/G cg18129178 chr5:148520854 ABLIM3 -0.59 -11.89 -0.43 1.37e-29 Breast cancer; BRCA cis rs6484504 0.576 rs438578 chr11:31222579 A/G cg14844989 chr11:31128820 NA 0.45 9.64 0.36 1.32e-20 Red blood cell count; BRCA cis rs9309711 0.772 rs9309714 chr2:3491830 G/C cg10845886 chr2:3471009 TTC15 -0.77 -16.25 -0.54 5.66e-50 Neurofibrillary tangles; BRCA cis rs10256972 0.552 rs6978842 chr7:1204599 A/C cg16145915 chr7:1198662 ZFAND2A -0.75 -23.42 -0.68 5.06e-88 Longevity;Endometriosis; BRCA cis rs17270561 0.609 rs2000350 chr6:25763154 T/C cg17691542 chr6:26056736 HIST1H1C 0.48 9.55 0.35 2.75e-20 Iron status biomarkers; BRCA cis rs13118159 0.550 rs2336081 chr4:1350322 A/G cg02475777 chr4:1388615 CRIPAK -0.67 -13.11 -0.46 5.99e-35 Longevity; BRCA cis rs875971 0.830 rs12673450 chr7:66009220 G/A cg18876405 chr7:65276391 NA 0.49 10.62 0.39 2.16e-24 Aortic root size; BRCA cis rs701145 0.537 rs1358403 chr3:153862757 C/T cg12800244 chr3:153838788 SGEF 0.62 7.83 0.3 2.1e-14 Coronary artery disease; BRCA cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.26 0.38 5.81e-23 Bipolar disorder; BRCA cis rs9467773 0.595 rs12525810 chr6:26623511 T/TA cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.29 -8.11 -0.31 2.64e-15 Intelligence (multi-trait analysis); BRCA trans rs8002861 0.641 rs4942252 chr13:44443039 C/T cg17145862 chr1:211918768 LPGAT1 0.47 10.69 0.39 1.16e-24 Leprosy; BRCA cis rs35306767 0.903 rs12769873 chr10:936526 G/T cg20503657 chr10:835505 NA 1.02 17.74 0.57 1.5e-57 Eosinophil percentage of granulocytes; BRCA cis rs10256972 0.721 rs4720249 chr7:1072563 C/G cg15112475 chr7:1198522 ZFAND2A -0.39 -8.4 -0.32 2.87e-16 Longevity;Endometriosis; BRCA cis rs8072100 0.777 rs9914653 chr17:45537395 T/C cg25173405 chr17:45401733 C17orf57 -0.57 -12.26 -0.44 3.51e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs7786808 0.712 rs2335167 chr7:158213948 A/C cg09998033 chr7:158218633 PTPRN2 -0.33 -7.91 -0.3 1.15e-14 Obesity-related traits; BRCA cis rs896854 0.738 rs1713669 chr8:95958637 C/G cg16049864 chr8:95962084 TP53INP1 -0.48 -10.72 -0.39 9.21e-25 Type 2 diabetes; BRCA cis rs208520 1.000 rs12212063 chr6:66985148 C/A cg07460842 chr6:66804631 NA 0.72 12.01 0.43 4.37e-30 Exhaled nitric oxide output; BRCA cis rs2016266 0.806 rs11170494 chr12:53665164 C/A cg26875137 chr12:53738046 NA 0.35 9.46 0.35 5.82e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs870825 0.860 rs72703519 chr4:185602707 G/A cg04058563 chr4:185651563 MLF1IP 0.65 11.26 0.41 5.77e-27 Blood protein levels; BRCA cis rs78456975 1.000 rs6708604 chr2:1556887 C/T cg26248373 chr2:1572462 NA -0.5 -9.62 -0.36 1.49e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs270601 0.739 rs1979981 chr5:131601720 G/A cg09877947 chr5:131593287 PDLIM4 0.46 11.17 0.4 1.37e-26 Acylcarnitine levels; BRCA cis rs1059312 1.000 rs7970815 chr12:129288366 G/A cg21616243 chr12:129299702 MGC16384;SLC15A4 -0.67 -15.67 -0.53 4.38e-47 Systemic lupus erythematosus; BRCA cis rs7829975 0.560 rs17154599 chr8:8551418 C/T cg15556689 chr8:8085844 FLJ10661 -0.31 -8.18 -0.31 1.48e-15 Mood instability; BRCA cis rs7647973 1.000 rs3448 chr3:49396751 T/C cg07636037 chr3:49044803 WDR6 0.74 15.91 0.53 3.01e-48 Menarche (age at onset); BRCA cis rs9921222 1.000 rs10794639 chr16:377367 A/G cg12437481 chr16:420112 MRPL28 -0.47 -11.84 -0.42 2.18e-29 Bone mineral density (spine);Bone mineral density; BRCA cis rs1865760 0.613 rs9295674 chr6:25912342 A/G cg03517284 chr6:25882590 NA -0.36 -8.42 -0.32 2.42e-16 Height; BRCA cis rs6032067 0.561 rs2741502 chr20:43936265 C/T cg20256260 chr20:43936981 MATN4;RBPJL 0.31 8.13 0.31 2.29e-15 Blood protein levels; BRCA trans rs11098499 0.863 rs3775844 chr4:120428033 G/A cg25214090 chr10:38739885 LOC399744 0.55 12.18 0.43 7.52e-31 Corneal astigmatism; BRCA cis rs877282 0.838 rs34912955 chr10:772222 T/C cg17470449 chr10:769945 NA 0.5 8.9 0.33 5.64e-18 Uric acid levels; BRCA cis rs6088580 0.634 rs6088484 chr20:32985961 T/C cg08999081 chr20:33150536 PIGU -0.46 -12.76 -0.45 2.3e-33 Glomerular filtration rate (creatinine); BRCA cis rs858239 0.539 rs4365988 chr7:23190871 T/C cg23682824 chr7:23144976 KLHL7 0.41 10.95 0.4 1.1e-25 Cerebrospinal fluid biomarker levels; BRCA cis rs7666738 0.830 rs72882693 chr4:98960804 T/A cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4478137 0.839 rs3967763 chr4:164239273 G/C cg06758707 chr4:164254230 NPY1R 0.57 12.46 0.44 4.7e-32 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs12142240 0.698 rs57267378 chr1:46816644 A/G cg10495392 chr1:46806563 NSUN4 0.44 8.18 0.31 1.49e-15 Menopause (age at onset); BRCA cis rs17711722 1.000 rs17711722 chr7:65271197 C/T cg11764359 chr7:65958608 NA -0.61 -13.45 -0.47 1.72e-36 Calcium levels; BRCA cis rs769267 0.930 rs7256149 chr19:19566255 T/C cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.21e-18 Tonsillectomy; BRCA cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg23711669 chr6:146136114 FBXO30 -0.79 -19.16 -0.6 5.32e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs7727544 0.716 rs72793278 chr5:131561372 C/A cg14196790 chr5:131705035 SLC22A5 0.4 10.15 0.37 1.51e-22 Blood metabolite levels; BRCA trans rs2204008 0.775 rs3900361 chr12:38238936 A/G cg06521331 chr12:34319734 NA 0.52 9.99 0.37 6.45e-22 Bladder cancer; BRCA cis rs13256369 0.802 rs11249887 chr8:8562184 T/C cg17143192 chr8:8559678 CLDN23 0.57 11.25 0.41 6.26e-27 Obesity-related traits; BRCA cis rs9443645 0.901 rs1572584 chr6:79690290 A/G cg05283184 chr6:79620031 NA 0.41 10.12 0.37 2.06e-22 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.580 rs10936227 chr3:161043869 A/C cg03342759 chr3:160939853 NMD3 -0.61 -13.44 -0.47 1.83e-36 Morning vs. evening chronotype; BRCA cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg08085267 chr17:45401833 C17orf57 0.6 12.4 0.44 8.84e-32 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs3008870 0.536 rs2208576 chr1:67513401 C/G cg08660285 chr1:67390436 MIER1;WDR78 -0.42 -8.47 -0.32 1.63e-16 Lymphocyte percentage of white cells; BRCA cis rs13102973 0.899 rs4643872 chr4:135901432 A/G cg14419869 chr4:135874104 NA 0.45 9.02 0.34 2.21e-18 Subjective well-being; BRCA cis rs765787 0.530 rs2899381 chr15:45529630 C/T cg15395560 chr15:45543142 SLC28A2 0.29 8.25 0.31 9.17e-16 Uric acid levels; BRCA cis rs7949030 0.596 rs71490394 chr11:62370155 G/A cg11742103 chr11:62369870 EML3;MTA2 0.54 13.28 0.47 1.01e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs11148252 0.740 rs9536052 chr13:52960709 C/G cg00495681 chr13:53174319 NA -0.39 -8.11 -0.31 2.6e-15 Lewy body disease; BRCA cis rs752010 0.619 rs10789406 chr1:42105182 G/T cg06885757 chr1:42089581 HIVEP3 -0.25 -9.08 -0.34 1.31e-18 Lupus nephritis in systemic lupus erythematosus; BRCA trans rs11992162 0.636 rs11250182 chr8:11807576 A/T cg06636001 chr8:8085503 FLJ10661 -0.49 -10.57 -0.39 3.49e-24 Monocyte count; BRCA cis rs4805272 0.512 rs8105613 chr19:29339151 C/T cg04546413 chr19:29218101 NA 0.5 8.62 0.32 5.46e-17 Plasma omega-3 polyunsaturated fatty acid levels (docosahexaenoic acid); BRCA cis rs8103278 1.000 rs7252126 chr19:46302374 T/A cg11657440 chr19:46296263 DMWD -0.54 -12.71 -0.45 3.84e-33 Coronary artery disease; BRCA cis rs7811142 0.830 rs6975660 chr7:99975266 A/G cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.7 -12.12 -0.43 1.4e-30 Platelet count; BRCA cis rs62229266 0.771 rs2835232 chr21:37393427 G/A cg12218747 chr21:37451666 NA -0.34 -8.08 -0.3 3.21e-15 Mitral valve prolapse; BRCA cis rs6951245 0.872 rs11768486 chr7:1101290 C/A cg23708337 chr7:1209742 NA 0.6 8.31 0.31 5.89e-16 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11105298 0.891 rs10858881 chr12:89891474 T/G cg00757033 chr12:89920650 WDR51B 0.53 10.64 0.39 1.92e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA trans rs877282 0.583 rs10904564 chr10:819459 C/G cg22713356 chr15:30763199 NA 1.03 16.73 0.55 2.29e-52 Uric acid levels; BRCA cis rs7666738 1.000 rs880471 chr4:98922541 C/T cg05340658 chr4:99064831 C4orf37 0.59 12.81 0.45 1.29e-33 Colonoscopy-negative controls vs population controls; BRCA cis rs35110281 0.592 rs6417729 chr21:44967202 A/C cg04455712 chr21:45112962 RRP1B 0.39 9.82 0.36 2.78e-21 Mean corpuscular volume; BRCA cis rs708547 0.647 rs1277308 chr4:57897864 C/T cg16868167 chr4:57843880 C4orf14;POLR2B 0.4 10.4 0.38 1.64e-23 Response to bleomycin (chromatid breaks); BRCA cis rs3733585 0.699 rs57574512 chr4:9960182 T/C cg00071950 chr4:10020882 SLC2A9 -0.45 -10.47 -0.38 9e-24 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs34172651 0.517 rs3803716 chr16:24802325 C/T cg00339695 chr16:24857497 SLC5A11 0.53 11.22 0.41 8.77e-27 Intelligence (multi-trait analysis); BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs9291683 0.552 rs17187075 chr4:9990328 G/C cg11266682 chr4:10021025 SLC2A9 0.44 11.54 0.42 4.15e-28 Bone mineral density; BRCA cis rs6690583 0.943 rs1837329 chr1:85469614 G/A cg11262906 chr1:85462892 MCOLN2 -0.47 -8.98 -0.33 3.08e-18 Serum sulfate level; BRCA cis rs12048904 0.505 rs6577209 chr1:101255080 A/C cg15686842 chr1:101360669 SLC30A7;EXTL2 0.43 9.6 0.36 1.77e-20 Multiple sclerosis; BRCA cis rs4363385 0.747 rs946101 chr1:152972032 C/T cg25856811 chr1:152973957 SPRR3 0.34 9.5 0.35 4.3e-20 Inflammatory skin disease; BRCA cis rs2130392 0.886 rs2077205 chr4:185637418 C/T cg21366198 chr4:185655624 MLF1IP -0.4 -9.55 -0.35 2.79e-20 Kawasaki disease; BRCA cis rs2576037 0.526 rs1539878 chr18:44523004 T/C cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.38 9.08 0.34 1.33e-18 Personality dimensions; BRCA cis rs17685 0.712 rs60721456 chr7:75743820 T/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.37 -8.29 -0.31 6.64e-16 Coffee consumption;Coffee consumption (cups per day); BRCA trans rs79976124 0.837 rs75346757 chr6:66648386 A/T cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.6 10.74 0.39 7.43e-25 Type 2 diabetes; BRCA cis rs8062405 0.720 rs9926245 chr16:28555706 T/A cg16576597 chr16:28551801 NUPR1 0.29 8.2 0.31 1.29e-15 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs250677 0.522 rs1432801 chr5:148390979 T/C cg18129178 chr5:148520854 ABLIM3 -0.55 -10.56 -0.39 3.75e-24 Breast cancer; BRCA cis rs2070488 0.775 rs6599207 chr3:38554901 T/C cg24069376 chr3:38537580 EXOG -0.33 -9.35 -0.35 1.5e-19 Electrocardiographic conduction measures; BRCA cis rs1997103 1.000 rs10252413 chr7:55396740 C/G cg17469321 chr7:55412551 NA 0.51 9.67 0.36 9.47e-21 QRS interval (sulfonylurea treatment interaction); BRCA cis rs801193 0.569 rs2707847 chr7:66202871 C/G cg11764359 chr7:65958608 NA 0.75 16.82 0.55 8.27e-53 Aortic root size; BRCA cis rs1552244 1.000 rs6764168 chr3:10123805 A/G cg13047869 chr3:10149882 C3orf24 0.59 12.37 0.44 1.16e-31 Alzheimer's disease; BRCA cis rs72781680 0.582 rs72783611 chr2:24291445 C/T cg08917208 chr2:24149416 ATAD2B 0.55 8.55 0.32 8.75e-17 Lymphocyte counts; BRCA cis rs9814567 0.806 rs13076825 chr3:134317239 G/A cg15484384 chr3:134203672 ANAPC13;CEP63 0.33 8.08 0.3 3.17e-15 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs6121246 0.954 rs6060992 chr20:30431255 G/T cg21427119 chr20:30132790 HM13 -0.43 -9.29 -0.35 2.34e-19 Mean corpuscular hemoglobin; BRCA trans rs12517041 1.000 rs4701219 chr5:23284067 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.32 -0.31 5.27e-16 Calcium levels; BRCA cis rs8177253 0.931 rs8177256 chr3:133480276 G/T cg11941060 chr3:133502564 NA -0.5 -11.89 -0.43 1.35e-29 Iron status biomarkers; BRCA cis rs9467773 1.000 rs4713006 chr6:26519872 A/G cg11502198 chr6:26597334 ABT1 0.48 9.58 0.35 2.09e-20 Intelligence (multi-trait analysis); BRCA cis rs1506636 0.512 rs1035015 chr7:123309842 G/C cg03229431 chr7:123269106 ASB15 0.5 8.26 0.31 8.4e-16 Plateletcrit;Platelet count; BRCA cis rs2153535 0.580 rs9393022 chr6:8466588 T/C cg23788917 chr6:8435910 SLC35B3 0.48 10.49 0.38 7.17e-24 Motion sickness; BRCA cis rs4478137 0.824 rs10857353 chr4:164215835 A/G cg06758707 chr4:164254230 NPY1R -0.54 -11.64 -0.42 1.53e-28 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs4363385 0.747 rs4240867 chr1:152954921 A/G cg24667326 chr1:152973720 SPRR3 0.34 10.05 0.37 3.61e-22 Inflammatory skin disease; BRCA cis rs798554 0.679 rs7784066 chr7:2819727 T/A cg19717773 chr7:2847554 GNA12 -0.41 -8.47 -0.32 1.71e-16 Height; BRCA cis rs6964587 1.000 rs1859113 chr7:91679887 T/C cg17063962 chr7:91808500 NA 0.54 12.72 0.45 3.47e-33 Breast cancer; BRCA cis rs60843830 0.661 rs55987018 chr2:106655 C/T cg25945732 chr2:264204 ACP1;SH3YL1 0.48 9.14 0.34 8.42e-19 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs10256972 0.552 rs7805591 chr7:1210745 A/G cg23978390 chr7:1156363 C7orf50 0.41 9.8 0.36 3.31e-21 Longevity;Endometriosis; BRCA cis rs2153535 0.580 rs1414348 chr6:8471940 A/G cg07606381 chr6:8435919 SLC35B3 0.64 13.98 0.48 6.08e-39 Motion sickness; BRCA cis rs10256972 0.706 rs4285396 chr7:1123738 A/G cg22907277 chr7:1156413 C7orf50 0.5 10.74 0.39 7.77e-25 Longevity;Endometriosis; BRCA cis rs17270561 0.639 rs9356989 chr6:25781950 A/G cg16482183 chr6:26056742 HIST1H1C 0.55 10.56 0.39 3.88e-24 Iron status biomarkers; BRCA cis rs7772486 0.686 rs2328708 chr6:146095739 G/A cg13319975 chr6:146136371 FBXO30 0.34 8.04 0.3 4.43e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs614226 1.000 rs1167726 chr12:120967364 A/C cg01236616 chr12:121019343 POP5 -1.23 -27.99 -0.74 4.13e-113 Type 1 diabetes nephropathy; BRCA cis rs9914988 0.943 rs4795465 chr17:27151498 A/G cg20469991 chr17:27169893 C17orf63 0.44 8.73 0.33 2.3e-17 High light scatter reticulocyte count;High light scatter reticulocyte percentage of red cells;Glycated hemoglobin levels; BRCA cis rs4930561 0.765 rs1894204 chr11:67929671 C/T cg16338278 chr11:67432957 ALDH3B2 0.44 9.1 0.34 1.14e-18 Breast cancer in childhood cancer survivors;IgG glycosylation; BRCA cis rs7666738 0.819 rs62318904 chr4:99036101 A/T cg17366294 chr4:99064904 C4orf37 0.47 10.97 0.4 8.76e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs9311474 0.652 rs411457 chr3:52228150 A/T cg15698299 chr3:52233019 ALAS1 0.36 8.31 0.31 5.53e-16 Electroencephalogram traits; BRCA cis rs7493 1.000 rs3779492 chr7:95044183 C/T cg19678392 chr7:94953810 PON1 -0.42 -8.93 -0.33 4.37e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs2070488 0.896 rs11914389 chr3:38527215 T/C cg24069376 chr3:38537580 EXOG 0.4 11.59 0.42 2.43e-28 Electrocardiographic conduction measures; BRCA cis rs4853036 1.000 rs13025205 chr2:70044159 C/G cg02498382 chr2:70120550 SNRNP27 -0.49 -8.89 -0.33 6.1e-18 Colorectal or endometrial cancer; BRCA cis rs7914558 1.000 rs7077291 chr10:104945751 C/T cg04362960 chr10:104952993 NT5C2 0.42 10.08 0.37 2.8e-22 Schizophrenia;Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined); BRCA cis rs55665837 1.000 rs11023216 chr11:14437153 G/A cg19336497 chr11:14380999 RRAS2 -0.36 -9.49 -0.35 4.37e-20 Vitamin D levels; BRCA cis rs9435341 0.965 rs56111229 chr1:107566689 T/A cg09367891 chr1:107599246 PRMT6 0.51 9.47 0.35 5.52e-20 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs8062405 1.000 rs62036622 chr16:28837203 T/G cg09754948 chr16:28834200 ATXN2L 0.47 8.87 0.33 7.16e-18 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA trans rs2018683 0.707 rs917219 chr7:28975343 A/G cg19402173 chr7:128379420 CALU -0.44 -10.56 -0.39 3.94e-24 Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer; BRCA cis rs853679 0.517 rs9380056 chr6:28104476 C/T cg18032046 chr6:28092343 ZSCAN16 -0.5 -8.14 -0.31 2.1e-15 Depression; BRCA cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg18479299 chr3:125709523 NA -0.54 -8.34 -0.31 4.59e-16 Blood pressure (smoking interaction); BRCA cis rs7647973 0.600 rs11920267 chr3:49275964 G/A cg07636037 chr3:49044803 WDR6 0.8 20.78 0.64 1.14e-73 Menarche (age at onset); BRCA cis rs798554 0.679 rs7807978 chr7:2814635 C/T cg19717773 chr7:2847554 GNA12 -0.42 -9.51 -0.35 3.75e-20 Height; BRCA cis rs8048589 0.515 rs4780412 chr16:12232409 A/G cg02910054 chr16:12241554 SNX29 0.44 9.3 0.35 2.13e-19 Homeostasis model assessment of insulin resistance (dietary factor interaction);Fasting insulin (dietary factor interaction); BRCA trans rs6089829 0.962 rs6122347 chr20:61661866 C/T cg23505145 chr19:12996616 KLF1 0.56 12.69 0.45 4.46e-33 Prostate cancer (SNP x SNP interaction); BRCA cis rs1065852 0.526 rs9611700 chr22:42401514 C/T cg22189786 chr22:42395067 WBP2NL 0.43 8.66 0.32 3.99e-17 Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels); BRCA cis rs2739330 0.760 rs5751761 chr22:24243736 A/G cg24846343 chr22:24311635 DDTL -0.49 -12.11 -0.43 1.63e-30 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs10504229 0.775 rs17804888 chr8:58158315 G/T cg08280861 chr8:58055591 NA -0.54 -8.58 -0.32 7.39e-17 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.541 rs9505456 chr6:8479001 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.92 0.33 4.98e-18 Motion sickness; BRCA trans rs3733585 0.673 rs4467564 chr4:9953472 G/T cg26043149 chr18:55253948 FECH -0.37 -8.17 -0.31 1.59e-15 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs2276314 0.802 rs9963714 chr18:33592056 T/C cg19628046 chr18:33552617 C18orf21 0.55 10.58 0.39 3.18e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs3806843 0.868 rs2262573 chr5:140123627 T/A cg26395211 chr5:140044315 WDR55 0.35 7.89 0.3 1.36e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs875971 1.000 rs6958277 chr7:65979349 A/G cg11764359 chr7:65958608 NA 0.8 19.21 0.6 3.07e-65 Aortic root size; BRCA cis rs2836950 0.565 rs7279497 chr21:40531306 A/G cg11644478 chr21:40555479 PSMG1 0.48 10.15 0.37 1.56e-22 Menarche (age at onset); BRCA cis rs9467773 0.935 rs9461270 chr6:26544110 A/G cg09904177 chr6:26538194 HMGN4 0.56 18.46 0.59 2.5e-61 Intelligence (multi-trait analysis); BRCA cis rs9682041 0.696 rs11709437 chr3:170085568 T/G cg11886554 chr3:170076028 SKIL 0.52 10.27 0.38 5.42e-23 Glomerular filtration rate in non diabetics (creatinine);Glomerular filtration rate (creatinine); BRCA cis rs312274 0.546 rs11178979 chr12:41299357 A/G cg17827154 chr12:41323612 CNTN1 -0.45 -11.25 -0.41 6.48e-27 Metabolite levels (X-11787); BRCA cis rs6951245 1.000 rs1997243 chr7:1083777 A/G cg18402987 chr7:1209562 NA 0.84 12.05 0.43 2.92e-30 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6570726 0.791 rs10457788 chr6:145921136 T/A cg05347473 chr6:146136440 FBXO30 0.42 8.16 0.31 1.84e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs1552244 0.938 rs67667957 chr3:10167264 G/C cg08888203 chr3:10149979 C3orf24 0.65 13.7 0.48 1.2e-37 Alzheimer's disease; BRCA cis rs477692 0.625 rs4751104 chr10:131405358 G/A cg24747557 chr10:131355152 MGMT 0.37 9.13 0.34 8.71e-19 Response to temozolomide; BRCA cis rs7746199 0.668 rs34864796 chr6:27459923 G/A cg08798685 chr6:27730294 NA -0.72 -8.9 -0.33 5.88e-18 Gait speed in old age;Autism spectrum disorder or schizophrenia; BRCA cis rs7552404 1.000 rs7552404 chr1:76135946 A/G cg10523679 chr1:76189770 ACADM 0.76 15.95 0.53 1.76e-48 Blood metabolite levels;Acylcarnitine levels; BRCA trans rs1493916 0.967 rs9953765 chr18:31399464 A/G cg15819921 chr19:927150 ARID3A -0.47 -8.98 -0.33 2.89e-18 Life satisfaction; BRCA cis rs17092148 0.887 rs2144956 chr20:33145868 G/A cg16810054 chr20:33298113 TP53INP2 -0.45 -10.08 -0.37 2.93e-22 Neuroticism; BRCA cis rs17253792 0.822 rs76055105 chr14:56069127 A/G cg01858014 chr14:56050164 KTN1 -0.76 -10.5 -0.38 6.49e-24 Putamen volume; BRCA cis rs2075371 0.673 rs35290398 chr7:134011773 C/T cg02659138 chr7:134003124 SLC35B4 0.4 11.57 0.42 3.18e-28 Mean platelet volume; BRCA cis rs700651 0.754 rs1518367 chr2:198807015 T/A cg00792783 chr2:198669748 PLCL1 0.44 9.75 0.36 4.75e-21 Intracranial aneurysm; BRCA cis rs9788721 0.836 rs72738732 chr15:78752188 C/G cg18825076 chr15:78729989 IREB2 -0.45 -8.76 -0.33 1.71e-17 Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio;Emphysema imaging phenotypes;Emphysema distribution in smoking;Local histogram emphysema pattern;Post bronchodilator FEV1/FVC ratio in COPD; BRCA cis rs4819052 0.851 rs13052344 chr21:46676101 C/T cg06618935 chr21:46677482 NA -0.38 -8.56 -0.32 8.68e-17 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs2197308 0.765 rs11182964 chr12:37935052 C/T cg26384229 chr12:38710491 ALG10B 0.76 17.07 0.56 4.41e-54 Morning vs. evening chronotype; BRCA cis rs2251381 0.741 rs2735966 chr21:30538174 G/A cg08807101 chr21:30365312 RNF160 0.57 12.37 0.44 1.2e-31 Selective IgA deficiency; BRCA cis rs2011503 1.000 rs78883953 chr19:19630002 G/A cg15839431 chr19:19639596 YJEFN3 -0.42 -9.15 -0.34 7.34e-19 Bipolar disorder; BRCA cis rs11112613 0.713 rs12307351 chr12:105955634 T/A cg03607813 chr12:105948248 NA 0.6 10.46 0.38 9.53e-24 Corrected insulin response;Corrected insulin response adjusted for insulin sensitivity index; BRCA cis rs11098499 0.909 rs28555550 chr4:120211040 C/G cg09307838 chr4:120376055 NA 0.65 13.19 0.46 2.55e-35 Corneal astigmatism; BRCA cis rs812925 0.537 rs2593620 chr2:61613261 A/G cg15711740 chr2:61764176 XPO1 0.32 7.9 0.3 1.2e-14 Immature fraction of reticulocytes; BRCA cis rs11190604 1.000 rs4919465 chr10:102221703 C/T cg07080220 chr10:102295463 HIF1AN 0.49 11.15 0.4 1.7e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs847577 0.575 rs41278842 chr7:97815999 A/G cg21770322 chr7:97807741 LMTK2 -0.46 -11.99 -0.43 5.09e-30 Breast cancer; BRCA cis rs7618501 0.633 rs9814664 chr3:50078541 C/T cg24308560 chr3:49941425 MST1R 0.39 8.48 0.32 1.56e-16 Intelligence (multi-trait analysis); BRCA cis rs7582180 0.845 rs11683088 chr2:100920667 C/T cg14675211 chr2:100938903 LONRF2 0.47 10.19 0.37 1.09e-22 Intelligence (multi-trait analysis); BRCA cis rs10206020 0.921 rs72778009 chr2:1573322 G/T cg12573674 chr2:1569213 NA -0.62 -14.09 -0.49 1.83e-39 IgG glycosylation; BRCA cis rs1008375 0.966 rs7666888 chr4:17695722 C/T cg02297831 chr4:17616191 MED28 0.35 8.14 0.31 2.1e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs2762353 0.935 rs3799340 chr6:25762646 C/T cg03264133 chr6:25882463 NA 0.49 10.98 0.4 8.45e-26 Blood metabolite levels; BRCA cis rs7586879 0.719 rs7565468 chr2:25130092 C/T cg04586622 chr2:25135609 ADCY3 0.4 9.53 0.35 3.3e-20 Body mass index; BRCA cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg00750074 chr16:89608354 SPG7 -0.38 -10.31 -0.38 3.68e-23 Multiple myeloma (IgH translocation); BRCA cis rs10463316 0.894 rs7727926 chr5:150767216 G/A cg03212797 chr5:150827313 SLC36A1 -0.43 -8.32 -0.31 5.17e-16 Metabolite levels (Pyroglutamine); BRCA cis rs10493773 0.609 rs11161651 chr1:86177816 A/G cg17807903 chr1:86174739 ZNHIT6 -0.53 -13.35 -0.47 4.72e-36 Urate levels in overweight individuals; BRCA cis rs2576037 0.583 rs512699 chr18:44374681 C/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 -0.61 -14.36 -0.49 1.03e-40 Personality dimensions; BRCA cis rs9814567 1.000 rs7637227 chr3:134244155 G/A cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.63 -0.61 1.73e-67 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs6952808 0.582 rs11763870 chr7:2027448 T/C cg04565464 chr8:145669602 NFKBIL2 -0.36 -9.12 -0.34 9.89e-19 Bipolar disorder and schizophrenia; BRCA cis rs875971 0.660 rs79009421 chr7:66068509 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.38 -8.31 -0.31 5.65e-16 Aortic root size; BRCA cis rs7618915 0.571 rs2289249 chr3:52597664 G/A cg18404041 chr3:52824283 ITIH1 -0.42 -12.11 -0.43 1.52e-30 Bipolar disorder; BRCA cis rs6866344 0.697 rs11743893 chr5:178125194 C/T cg03877680 chr5:178157825 ZNF354A 0.78 14.61 0.5 6.26e-42 Neutrophil percentage of white cells; BRCA cis rs9810890 1.000 rs73196988 chr3:128453467 G/A cg15033153 chr3:128514015 RAB7A 0.7 8.08 0.3 3.34e-15 Dental caries; BRCA cis rs12618769 0.570 rs17032866 chr2:99132415 A/G cg10123293 chr2:99228465 UNC50 0.41 8.24 0.31 9.93e-16 Bipolar disorder; BRCA cis rs2762353 0.935 rs3757130 chr6:25770866 C/T cg03264133 chr6:25882463 NA 0.49 10.97 0.4 9.32e-26 Blood metabolite levels; BRCA trans rs3780486 0.846 rs7873903 chr9:33142728 G/A cg04842962 chr6:43655489 MRPS18A 1.12 37.97 0.83 5.95e-166 IgG glycosylation; BRCA cis rs595982 0.527 rs73061658 chr19:49372376 G/C cg15549821 chr19:49342101 PLEKHA4 -0.71 -11.43 -0.41 1.2100000000000001e-27 Red cell distribution width; BRCA cis rs2294693 0.945 rs9349175 chr6:40982401 T/C cg14418226 chr6:40996092 UNC5CL 0.44 7.97 0.3 7.14e-15 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs1008375 1.000 rs10939749 chr4:17692319 A/C cg04450456 chr4:17643702 FAM184B 0.32 9.34 0.35 1.5700000000000001e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8114671 0.562 rs2424999 chr20:33386430 G/A cg24642439 chr20:33292090 TP53INP2 0.42 8.82 0.33 1.1e-17 Height; BRCA trans rs12517041 1.000 rs7737671 chr5:23288400 C/G ch.8.1293020R chr8:59333349 UBXN2B -0.46 -8.36 -0.31 4.04e-16 Calcium levels; BRCA cis rs1547553 1 rs1547553 chr18:77926197 C/A cg14906638 chr18:78001859 PARD6G -0.58 -9.7 -0.36 7.75e-21 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6952809 0.532 rs6956223 chr7:2431331 T/C cg23289794 chr7:2394357 EIF3B -0.66 -12.14 -0.43 1.2e-30 Multiple sclerosis; BRCA cis rs2832077 0.824 rs4816333 chr21:30201777 C/G cg08807101 chr21:30365312 RNF160 -0.47 -8.01 -0.3 5.52e-15 Cognitive test performance; BRCA cis rs17376456 0.877 rs12374463 chr5:93483569 C/G cg21475434 chr5:93447410 FAM172A 0.69 8.69 0.33 2.92e-17 Diabetic retinopathy; BRCA cis rs4332037 0.510 rs58673065 chr7:1885600 A/G cg23422044 chr7:1970798 MAD1L1 -0.47 -9.9 -0.36 1.38e-21 Bipolar disorder; BRCA cis rs9790314 0.690 rs7633857 chr3:160844942 C/G cg03342759 chr3:160939853 NMD3 -0.53 -11.33 -0.41 3.02e-27 Morning vs. evening chronotype; BRCA trans rs9329221 0.527 rs4841352 chr8:10327590 A/C cg15556689 chr8:8085844 FLJ10661 0.33 8.49 0.32 1.5e-16 Neuroticism; BRCA cis rs12545109 0.959 rs12547974 chr8:57314785 G/T cg09654669 chr8:57350985 NA -0.38 -8.05 -0.3 4.1e-15 Obesity-related traits; BRCA cis rs6951245 0.554 rs10270249 chr7:1151886 G/T cg03188948 chr7:1209495 NA 0.69 11.62 0.42 1.85e-28 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4727027 0.866 rs1405124 chr7:148779618 C/T cg23583168 chr7:148888333 NA -0.82 -18.94 -0.6 7.99e-64 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs780096 0.526 rs3845686 chr2:27655447 T/G cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.31 -8.08 -0.3 3.26e-15 Total body bone mineral density; BRCA cis rs72615157 0.634 rs11762932 chr7:99792666 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 -0.61 -10.46 -0.38 9.79e-24 Lung function (FEV1/FVC); BRCA cis rs9311474 0.508 rs6788887 chr3:52605005 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.37 12.51 0.44 2.82e-32 Electroencephalogram traits; BRCA cis rs9467773 0.596 rs3001369 chr6:26670969 C/T cg11502198 chr6:26597334 ABT1 0.54 11.45 0.41 9.26e-28 Intelligence (multi-trait analysis); BRCA cis rs8177253 0.798 rs9871148 chr3:133507509 T/C cg01448562 chr3:133502909 NA -0.72 -17.58 -0.57 1.01e-56 Iron status biomarkers; BRCA cis rs7666738 0.830 rs1115616 chr4:99006603 A/C cg17366294 chr4:99064904 C4orf37 0.45 10.72 0.39 8.75e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs35146811 0.883 rs4134903 chr7:99711040 G/A cg22906224 chr7:99728672 NA 0.45 8.59 0.32 6.5e-17 Coronary artery disease; BRCA cis rs870825 0.655 rs35397385 chr4:185639095 C/T cg04058563 chr4:185651563 MLF1IP 0.77 17.27 0.56 3.85e-55 Blood protein levels; BRCA cis rs2882667 0.931 rs10075893 chr5:138355871 A/G cg04439458 chr5:138467593 SIL1 0.34 9.33 0.35 1.75e-19 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs6088813 1.000 rs6142374 chr20:33985568 C/T cg14752227 chr20:34000481 UQCC -0.43 -9.08 -0.34 1.39e-18 Height; BRCA cis rs769267 0.965 rs2074299 chr19:19380646 T/C cg20644253 chr19:19431407 KIAA0892;SF4 0.6 12.02 0.43 3.86e-30 Tonsillectomy; BRCA cis rs877282 0.898 rs12354872 chr10:763362 G/A cg17470449 chr10:769945 NA 0.47 7.92 0.3 1.08e-14 Uric acid levels; BRCA cis rs911119 0.908 rs12624424 chr20:23601878 C/T cg16589663 chr20:23618590 CST3 0.44 8.13 0.31 2.31e-15 Chronic kidney disease; BRCA trans rs60843830 0.662 rs6721594 chr2:305203 C/T cg11347411 chr7:150020925 ACTR3C;LRRC61 -0.62 -14.19 -0.49 6.18e-40 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs2070997 0.816 rs9695008 chr9:133720877 C/T cg11464064 chr9:133710261 ABL1 0.58 9.24 0.34 3.58e-19 Response to amphetamines; BRCA cis rs2243480 1.000 rs313813 chr7:65503500 C/T cg18252515 chr7:66147081 NA -0.93 -13.3 -0.47 8.69e-36 Diabetic kidney disease; BRCA cis rs6066825 0.555 rs6019378 chr20:47309716 C/T cg18078177 chr20:47281410 PREX1 0.39 9.58 0.35 2.02e-20 Colorectal cancer; BRCA cis rs9858542 1.000 rs9882740 chr3:49702484 T/C cg03060546 chr3:49711283 APEH -0.57 -11.4 -0.41 1.61e-27 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs10504229 0.728 rs17215753 chr8:58153764 A/G cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs2153535 0.580 rs1932276 chr6:8442593 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs12142240 0.698 rs66516678 chr1:46810112 G/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs9487051 0.768 rs12176068 chr6:109521629 C/T cg01475377 chr6:109611718 NA -0.45 -11.4 -0.41 1.58e-27 Reticulocyte fraction of red cells; BRCA cis rs6951245 1.000 rs11766526 chr7:1101433 G/A cg26224354 chr7:1096374 C7orf50;GPR146 -1.05 -19.05 -0.6 1.99e-64 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs250677 0.641 rs2915807 chr5:148450950 A/G cg18129178 chr5:148520854 ABLIM3 -0.63 -12.33 -0.44 1.69e-31 Breast cancer; BRCA cis rs739401 0.611 rs402276 chr11:3051404 C/G cg05729581 chr11:3078854 CARS -0.35 -8.77 -0.33 1.65e-17 Longevity; BRCA cis rs6951245 1.000 rs79327308 chr7:1108141 A/C cg08132940 chr7:1081526 C7orf50 -0.6 -8.74 -0.33 2.03e-17 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs9660180 0.875 rs4648727 chr1:1776269 C/A cg13866156 chr1:1669148 SLC35E2 0.41 8.92 0.33 4.86e-18 Body mass index; BRCA cis rs780096 0.526 rs780117 chr2:27698343 C/G cg12000995 chr2:27665139 KRTCAP3 -0.36 -9.04 -0.34 1.79e-18 Total body bone mineral density; BRCA cis rs611744 0.625 rs4735055 chr8:109286642 G/A cg21045802 chr8:109455806 TTC35 0.35 8.08 0.3 3.19e-15 Dupuytren's disease; BRCA trans rs61931739 0.500 rs7133447 chr12:34041901 A/G cg26384229 chr12:38710491 ALG10B 0.51 11.2 0.41 1.05e-26 Morning vs. evening chronotype; BRCA trans rs11088226 1.000 rs11701627 chr21:33927794 T/A cg09050820 chr6:167586206 TCP10L2 0.5 8.8 0.33 1.26e-17 Gastritis; BRCA trans rs11039798 0.512 rs28453037 chr11:49006929 C/A cg15704280 chr7:45808275 SEPT13 0.58 9.84 0.36 2.22e-21 Axial length; BRCA cis rs7666738 0.830 rs7662218 chr4:98983126 T/G cg05340658 chr4:99064831 C4orf37 0.67 16.84 0.55 6e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs1862618 0.853 rs1423621 chr5:56101035 G/T cg24531977 chr5:56204891 C5orf35 -0.8 -16.77 -0.55 1.32e-52 Initial pursuit acceleration; BRCA cis rs7618915 0.547 rs34610878 chr3:52759169 G/C cg10802521 chr3:52805072 NEK4 -0.32 -8.38 -0.31 3.4e-16 Bipolar disorder; BRCA cis rs2239547 0.522 rs2581801 chr3:52972907 G/T cg11645453 chr3:52864694 ITIH4 -0.47 -11.59 -0.42 2.61e-28 Schizophrenia; BRCA cis rs6088580 0.660 rs6059893 chr20:33105897 T/G cg08999081 chr20:33150536 PIGU 0.46 12.92 0.46 4.19e-34 Glomerular filtration rate (creatinine); BRCA cis rs832540 0.830 rs252907 chr5:56120646 G/A cg24531977 chr5:56204891 C5orf35 -0.41 -8.45 -0.32 1.93e-16 Coronary artery disease; BRCA cis rs7258465 0.931 rs8107347 chr19:18612748 G/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.63 -0.32 4.88e-17 Breast cancer; BRCA cis rs7249142 0.562 rs2314035 chr19:19284920 T/C cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.47 -11.16 -0.4 1.49e-26 IgG glycosylation; BRCA cis rs6951245 1.000 rs77702926 chr7:1088838 G/A cg20603222 chr7:1096387 C7orf50;GPR146 -0.92 -15.52 -0.52 2.52e-46 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs41005 1.000 rs42357 chr2:8110896 C/T cg03155496 chr2:8117019 LOC339788 0.57 15.39 0.52 1.08e-45 Response to anti-TNF therapy in rheumatoid arthritis; BRCA cis rs798554 0.797 rs1182174 chr7:2875420 G/A cg04166393 chr7:2884313 GNA12 0.51 9.65 0.36 1.18e-20 Height; BRCA cis rs7552404 0.731 rs12078299 chr1:76365764 T/A cg03433033 chr1:76189801 ACADM 0.71 13.13 0.46 5.04e-35 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs709400 0.663 rs10141388 chr14:103939679 A/G cg24130564 chr14:104152367 KLC1 -0.34 -7.88 -0.3 1.45e-14 Body mass index; BRCA cis rs1348850 0.526 rs2141157 chr2:178374112 C/T cg27490568 chr2:178487706 NA 0.5 8.4 0.32 2.91e-16 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs8177253 0.965 rs1525889 chr3:133490033 A/C cg12373951 chr3:133503437 NA 0.44 10.28 0.38 4.83e-23 Iron status biomarkers; BRCA cis rs7959452 0.590 rs11177628 chr12:69765421 G/A cg14784868 chr12:69753453 YEATS4 0.68 19.81 0.62 1.79e-68 Blood protein levels; BRCA cis rs977987 0.806 rs72787160 chr16:75445162 G/C cg03315344 chr16:75512273 CHST6 0.53 12.46 0.44 4.72e-32 Dupuytren's disease; BRCA cis rs1005277 0.579 rs1780138 chr10:38501654 A/G cg00409905 chr10:38381863 ZNF37A -0.53 -11.43 -0.41 1.22e-27 Extrinsic epigenetic age acceleration; BRCA cis rs4594175 1.000 rs4594175 chr14:51606541 C/A cg23942311 chr14:51606299 NA 0.34 8.66 0.32 3.85e-17 Cancer; BRCA cis rs7618501 0.633 rs13060128 chr3:50025028 A/G cg05623727 chr3:50126028 RBM5 0.44 10.44 0.38 1.14e-23 Intelligence (multi-trait analysis); BRCA cis rs6542838 0.671 rs6752025 chr2:99505699 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.4 -9.24 -0.34 3.51e-19 Fear of minor pain; BRCA trans rs1493916 0.870 rs8083723 chr18:31384398 C/T cg15819921 chr19:927150 ARID3A -0.48 -9.38 -0.35 1.15e-19 Life satisfaction; BRCA cis rs9309473 0.519 rs6746971 chr2:73669462 A/G cg20560298 chr2:73613845 ALMS1 -0.41 -11.22 -0.41 8.42e-27 Metabolite levels; BRCA cis rs1030877 0.515 rs17030766 chr2:105911905 G/A cg02079111 chr2:105885981 TGFBRAP1 -0.54 -9.85 -0.36 2.18e-21 Obesity-related traits; BRCA cis rs7666738 0.830 rs13129479 chr4:98987860 T/C cg05340658 chr4:99064831 C4orf37 0.68 17.04 0.56 6.18e-54 Colonoscopy-negative controls vs population controls; BRCA cis rs3858526 0.584 rs10734560 chr11:5864503 G/T cg05234568 chr11:5960015 NA -0.42 -8.8 -0.33 1.29e-17 DNA methylation (variation); BRCA cis rs1552244 1.000 rs68067759 chr3:10150535 T/C cg10729496 chr3:10149963 C3orf24 0.48 9.16 0.34 6.82e-19 Alzheimer's disease; BRCA cis rs7666738 0.830 rs13106434 chr4:98991651 T/A cg03676636 chr4:99064102 C4orf37 0.2 7.89 0.3 1.33e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs8177253 1.000 rs8177248 chr3:133479626 C/T cg16414030 chr3:133502952 NA -0.47 -10.82 -0.39 3.73e-25 Iron status biomarkers; BRCA cis rs3096299 0.754 rs2965816 chr16:89514183 G/T cg08822215 chr16:89438651 ANKRD11 0.38 8.24 0.31 9.99e-16 Multiple myeloma (IgH translocation); BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg03188948 chr7:1209495 NA -0.47 -8.63 -0.32 5.02e-17 Longevity;Endometriosis; BRCA cis rs495337 0.706 rs671130 chr20:48477458 G/A cg17835207 chr20:48524531 SPATA2 -0.5 -11.06 -0.4 3.87e-26 Psoriasis; BRCA cis rs7617773 0.817 rs936426 chr3:48215253 C/T cg11946769 chr3:48343235 NME6 0.6 13.33 0.47 5.79e-36 Coronary artery disease; BRCA cis rs9467711 0.591 rs35528636 chr6:25995701 A/C cg19084075 chr6:26124329 HIST1H2AC;HIST1H2BC 0.59 9.24 0.34 3.63e-19 Autism spectrum disorder or schizophrenia; BRCA cis rs739401 0.611 rs2239900 chr11:3030992 C/T cg05729581 chr11:3078854 CARS -0.33 -8.02 -0.3 5e-15 Longevity; BRCA cis rs7833790 0.724 rs10958045 chr8:82722994 T/C cg17211192 chr8:82754475 SNX16 -0.52 -11.94 -0.43 8.29e-30 Diastolic blood pressure; BRCA cis rs7811142 0.887 rs35111986 chr7:100000274 C/A cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 16.93 0.56 2.15e-53 Platelet count; BRCA cis rs700651 0.821 rs700663 chr2:198670478 T/A cg00792783 chr2:198669748 PLCL1 0.47 10.27 0.38 5.27e-23 Intracranial aneurysm; BRCA cis rs9291683 0.609 rs7678012 chr4:9993772 T/C cg11266682 chr4:10021025 SLC2A9 0.42 11.2 0.41 1.03e-26 Bone mineral density; BRCA cis rs9462846 1.000 rs9462846 chr6:42861581 A/C cg02353165 chr6:42928485 GNMT 0.48 8.61 0.32 5.61e-17 Blood protein levels; BRCA cis rs17228212 1.000 rs10152307 chr15:67444498 C/T cg26876701 chr15:67458665 SMAD3 -0.47 -9.19 -0.34 5.52e-19 Coronary heart disease; BRCA cis rs6570726 0.643 rs9403735 chr6:145936591 C/T cg05347473 chr6:146136440 FBXO30 0.41 8.03 0.3 4.76e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs765787 0.530 rs2413786 chr15:45525394 C/A cg15395560 chr15:45543142 SLC28A2 0.3 8.32 0.31 5.52e-16 Uric acid levels; BRCA cis rs6089829 0.962 rs3899032 chr20:61658542 G/A cg03213289 chr20:61660250 NA 0.62 15.95 0.53 1.88e-48 Prostate cancer (SNP x SNP interaction); BRCA cis rs17376456 0.877 rs114256265 chr5:93473130 T/A cg25358565 chr5:93447407 FAM172A 1.21 19.85 0.62 1.16e-68 Diabetic retinopathy; BRCA cis rs9814567 1.000 rs62271514 chr3:134298554 A/G cg06109529 chr3:134205091 CEP63;ANAPC13 0.6 19.45 0.61 1.5e-66 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs4665809 1.000 rs750450 chr2:26324631 A/G cg26119090 chr2:26468346 HADHA;HADHB -0.7 -12.72 -0.45 3.52e-33 Gut microbiome composition (summer); BRCA cis rs10256972 0.591 rs11766651 chr7:1161646 A/G cg16145915 chr7:1198662 ZFAND2A -0.66 -16.3 -0.54 3.49e-50 Longevity;Endometriosis; BRCA cis rs4665809 0.590 rs35532350 chr2:26441605 T/C cg08470875 chr2:26401718 FAM59B -0.71 -11.35 -0.41 2.41e-27 Gut microbiome composition (summer); BRCA cis rs7618915 0.508 rs12498066 chr3:52627660 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.34 11.03 0.4 4.9e-26 Bipolar disorder; BRCA cis rs360798 0.532 rs7573756 chr2:62990637 G/A cg17519650 chr2:63277830 OTX1 -0.36 -7.89 -0.3 1.33e-14 Coronary artery disease; BRCA cis rs2836950 0.565 rs8131132 chr21:40538256 T/C cg17971929 chr21:40555470 PSMG1 -0.47 -10.26 -0.38 5.89e-23 Menarche (age at onset); BRCA cis rs68170813 0.559 rs4730226 chr7:106887274 A/C cg02696742 chr7:106810147 HBP1 -0.52 -8.47 -0.32 1.67e-16 Coronary artery disease; BRCA cis rs58688157 0.705 rs36060383 chr11:598723 A/C cg16486109 chr11:613632 IRF7 0.41 8.77 0.33 1.65e-17 Systemic lupus erythematosus; BRCA cis rs1577917 1.000 rs955197 chr6:86729675 G/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.5 -12.9 -0.45 5.18e-34 Response to antipsychotic treatment; BRCA cis rs3092073 0.819 rs3848715 chr20:44564682 G/A cg17986701 chr20:44574422 PCIF1 -0.32 -7.84 -0.3 1.85e-14 Intelligence (multi-trait analysis); BRCA cis rs2580764 0.598 rs2580772 chr2:55218805 G/T cg09592903 chr2:55203963 RTN4 0.4 10.17 0.37 1.25e-22 Mean platelet volume; BRCA cis rs1878931 0.520 rs12447807 chr16:3413896 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 0.96 25.27 0.71 3.16e-98 Body mass index (adult); BRCA cis rs7584330 0.518 rs7585975 chr2:238439089 G/A cg08992911 chr2:238395768 MLPH 0.49 8.16 0.31 1.82e-15 Prostate cancer; BRCA cis rs9811920 0.683 rs7650727 chr3:99688976 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.46 -11.09 -0.4 2.87e-26 Axial length; BRCA cis rs1008375 1.000 rs13106338 chr4:17676871 G/T cg15017067 chr4:17643749 FAM184B -0.29 -8.72 -0.33 2.44e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs35306767 0.761 rs11253537 chr10:1010735 G/A cg10556349 chr10:835070 NA 0.63 8.68 0.32 3.23e-17 Eosinophil percentage of granulocytes; BRCA cis rs8114671 0.562 rs4911449 chr20:33512236 T/G cg07148914 chr20:33460835 GGT7 0.38 8.57 0.32 7.57e-17 Height; BRCA cis rs6582630 0.555 rs8189479 chr12:38308240 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.03 -0.37 4.35e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs6570726 0.934 rs430003 chr6:145819506 C/T cg23711669 chr6:146136114 FBXO30 0.64 15.14 0.51 1.72e-44 Lobe attachment (rater-scored or self-reported); BRCA cis rs853679 0.517 rs9393893 chr6:28109262 T/C cg02631126 chr6:28058918 ZSCAN12L1 0.27 7.95 0.3 8.6e-15 Depression; BRCA cis rs26949 0.526 rs10058456 chr5:60037941 T/C cg02684056 chr5:59996105 DEPDC1B -0.34 -7.89 -0.3 1.32e-14 Intelligence (multi-trait analysis); BRCA cis rs16958440 1.000 rs62096474 chr18:44647504 G/A cg17192377 chr18:44677553 HDHD2 0.67 9.8 0.36 3.16e-21 Sitting height ratio; BRCA cis rs12220238 1.000 rs10824129 chr10:76008855 G/A cg19889307 chr10:75911429 ADK;AP3M1 0.5 8.32 0.31 5.44e-16 Soluble interleukin-2 receptor subunit alpha; BRCA trans rs1945213 0.694 rs34537090 chr11:55843285 G/C cg15704280 chr7:45808275 SEPT13 0.59 10.5 0.38 6.77e-24 Acute lymphoblastic leukemia (childhood); BRCA cis rs6121246 0.559 rs6060932 chr20:30350545 A/G cg21427119 chr20:30132790 HM13 -0.36 -8.12 -0.31 2.35e-15 Mean corpuscular hemoglobin; BRCA cis rs7811142 0.830 rs1063945 chr7:99930447 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.01 17.09 0.56 3.15e-54 Platelet count; BRCA cis rs7772486 0.754 rs6570718 chr6:146088443 T/G cg23711669 chr6:146136114 FBXO30 -0.8 -19.22 -0.61 2.46e-65 Lobe attachment (rater-scored or self-reported); BRCA cis rs35110281 0.715 rs8129601 chr21:45119104 A/G cg04455712 chr21:45112962 RRP1B 0.44 12.14 0.43 1.13e-30 Mean corpuscular volume; BRCA cis rs1008375 1.000 rs4698635 chr4:17630242 C/A cg04450456 chr4:17643702 FAM184B 0.37 10.67 0.39 1.39e-24 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10540 1.000 rs61876335 chr11:488878 T/C cg03352830 chr11:487213 PTDSS2 0.75 11.75 0.42 5.39e-29 Body mass index; BRCA cis rs9463078 0.774 rs6458441 chr6:45327401 G/T cg25276700 chr6:44698697 NA 0.35 7.88 0.3 1.42e-14 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs6963495 0.818 rs55691539 chr7:105165774 T/C cg19920283 chr7:105172520 RINT1 0.59 9.4 0.35 9.51e-20 Bipolar disorder (body mass index interaction); BRCA cis rs2739330 0.796 rs2154594 chr22:24254055 A/G cg04234412 chr22:24373322 LOC391322 0.62 15.29 0.52 3.18e-45 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs858239 0.600 rs10256524 chr7:23144947 T/C cg23682824 chr7:23144976 KLHL7 0.46 12.23 0.44 4.72e-31 Cerebrospinal fluid biomarker levels; BRCA cis rs1008375 0.932 rs1008894 chr4:17704667 C/T cg04450456 chr4:17643702 FAM184B -0.33 -9.37 -0.35 1.24e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA trans rs57221529 0.766 rs4081846 chr5:574019 G/A cg11887960 chr12:57824829 NA 0.54 8.6 0.32 6.25e-17 Lung disease severity in cystic fibrosis; BRCA cis rs4665809 0.590 rs6730317 chr2:26419482 C/T cg04944784 chr2:26401820 FAM59B -1.01 -16.81 -0.55 8.38e-53 Gut microbiome composition (summer); BRCA cis rs4845570 1.000 rs6673002 chr1:151743275 G/T cg07092448 chr1:151763213 TDRKH 0.85 17.12 0.56 2.34e-54 Coronary artery disease; BRCA cis rs10254118 0.757 rs7788086 chr7:133135206 C/T cg10665199 chr7:133106180 EXOC4 0.48 10.15 0.37 1.53e-22 Intelligence (multi-trait analysis); BRCA cis rs2115630 0.967 rs11073731 chr15:85355113 C/A cg12863693 chr15:85201151 NMB -0.36 -8.51 -0.32 1.21e-16 P wave terminal force; BRCA cis rs2836950 0.565 rs2836931 chr21:40546569 T/G cg06238570 chr21:40685208 BRWD1 -0.39 -7.94 -0.3 9.01e-15 Menarche (age at onset); BRCA cis rs4665809 0.549 rs34075014 chr2:26520842 T/C cg25036284 chr2:26402008 FAM59B 0.94 13.9 0.48 1.37e-38 Gut microbiome composition (summer); BRCA cis rs13191362 1.000 rs34192365 chr6:163012382 T/G cg21926612 chr6:163149169 PACRG;PARK2 0.88 14.33 0.49 1.3e-40 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs10782582 0.593 rs12131493 chr1:76139172 G/A cg03433033 chr1:76189801 ACADM -0.46 -9.39 -0.35 1.01e-19 Daytime sleep phenotypes; BRCA trans rs970548 0.657 rs11239572 chr10:46088061 C/T cg20477318 chr10:51623047 TIMM23 -0.44 -7.85 -0.3 1.77e-14 Total cholesterol levels;Cholesterol, total;HDL cholesterol;HDL cholesterol levels; BRCA cis rs4925386 0.840 rs6143024 chr20:60914229 A/G cg22307297 chr20:60903441 LAMA5 0.37 10.02 0.37 4.92e-22 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs1580019 0.563 rs4723169 chr7:32567577 G/A cg07520158 chr7:32535189 LSM5;AVL9 0.49 10.99 0.4 7.21e-26 Cognitive ability; BRCA cis rs9467773 1.000 rs1056667 chr6:26510564 T/C cg11502198 chr6:26597334 ABT1 0.48 9.53 0.35 3.23e-20 Intelligence (multi-trait analysis); BRCA cis rs921968 0.541 rs2241527 chr2:219537224 A/G cg02176678 chr2:219576539 TTLL4 0.54 13.61 0.47 3.15e-37 Mean corpuscular hemoglobin concentration; BRCA cis rs10193935 0.786 rs13399052 chr2:42385151 G/A cg27598129 chr2:42591480 NA -0.86 -14.67 -0.5 3.26e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs6840360 0.550 rs7683134 chr4:152503362 A/C cg22705602 chr4:152727874 NA -0.32 -7.88 -0.3 1.44e-14 Intelligence (multi-trait analysis); BRCA cis rs1801251 0.896 rs4973561 chr2:233687337 C/G cg08000102 chr2:233561755 GIGYF2 -0.6 -13.31 -0.47 7.7e-36 Coronary artery disease; BRCA cis rs12541635 0.966 rs55729609 chr8:107056034 A/C cg10147462 chr8:107024639 NA 0.37 9.74 0.36 5.53e-21 Age of smoking initiation; BRCA cis rs17376456 0.877 rs9314093 chr5:93333347 G/A cg25358565 chr5:93447407 FAM172A 1.14 18.03 0.58 4.84e-59 Diabetic retinopathy; BRCA cis rs10504229 0.775 rs55734109 chr8:58162322 G/A cg24829409 chr8:58192753 C8orf71 -0.48 -8.02 -0.3 5.2e-15 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs17357711 chr1:46829013 A/G cg00530320 chr1:46809349 NSUN4 0.49 9.75 0.36 5.11e-21 Menopause (age at onset); BRCA cis rs11711311 0.869 rs1026364 chr3:113370010 G/T cg06805542 chr3:113465803 ATP6V1A;NAA50 -0.42 -9.18 -0.34 5.87e-19 IgG glycosylation; BRCA cis rs2777491 0.957 rs316614 chr15:41746625 A/G cg18705301 chr15:41695430 NDUFAF1 -0.66 -15.95 -0.53 1.91e-48 Ulcerative colitis; BRCA cis rs7666738 0.830 rs10014284 chr4:98681951 G/C cg05340658 chr4:99064831 C4orf37 0.63 14.73 0.5 1.74e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs3733585 0.673 rs6814664 chr4:9956228 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.34 -0.38 2.73e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs3733585 0.673 rs9993410 chr4:9951264 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.44 -0.38 1.1e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs1800469 1.000 rs2241712 chr19:41869756 C/T cg08477640 chr19:41863820 B9D2 0.52 9.97 0.37 7.58e-22 Colorectal cancer; BRCA cis rs477895 0.653 rs66648159 chr11:63899429 G/A cg04317338 chr11:64019027 PLCB3 0.54 9.59 0.35 1.99e-20 Mean platelet volume; BRCA cis rs7809950 0.954 rs2520242 chr7:107136320 G/T cg23024343 chr7:107201750 COG5 0.41 9.43 0.35 7.5e-20 Coronary artery disease; BRCA cis rs7811142 1.000 rs67163493 chr7:100023838 C/T cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.08 21.81 0.65 2.95e-79 Platelet count; BRCA cis rs9287719 0.967 rs6432126 chr2:10757101 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.16 -0.31 1.79e-15 Prostate cancer; BRCA trans rs7615952 0.599 rs6803160 chr3:125709554 G/T cg07211511 chr3:129823064 LOC729375 -0.62 -11.06 -0.4 3.89e-26 Blood pressure (smoking interaction); BRCA cis rs559928 0.606 rs56207008 chr11:63883215 C/T cg19465662 chr11:63993652 NUDT22;TRPT1 0.83 10.89 0.4 1.85e-25 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs11098499 0.863 rs11933966 chr4:120476715 G/A cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs7777484 0.534 rs2258709 chr7:2832365 C/T cg18446336 chr7:2847575 GNA12 0.39 9.29 0.34 2.36e-19 Height; BRCA cis rs13053817 1.000 rs71324766 chr22:29839659 A/T cg20285224 chr22:29838184 RFPL1S;RFPL1 -0.51 -9.52 -0.35 3.61e-20 Carotid atherosclerosis in HIV infection; BRCA cis rs7309 0.810 rs11684253 chr2:162034536 G/T cg22496339 chr2:162101262 NA 0.58 13.08 0.46 8.37e-35 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis);Educational attainment; BRCA cis rs13136331 0.680 rs2732208 chr4:88650530 C/T cg22416721 chr4:88570574 DMP1 -0.57 -13.12 -0.46 5.17e-35 Sitting height ratio; BRCA cis rs7474896 0.559 rs2738185 chr10:38247736 G/A cg25427524 chr10:38739819 LOC399744 0.52 9.61 0.36 1.68e-20 Obesity (extreme); BRCA trans rs6582630 0.537 rs1829579 chr12:38420555 A/G cg06521331 chr12:34319734 NA -0.46 -8.57 -0.32 8.05e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs1552244 1.000 rs35741213 chr3:10087661 A/G cg00149659 chr3:10157352 C3orf10 0.78 13.55 0.47 6.28e-37 Alzheimer's disease; BRCA cis rs523522 0.926 rs10849766 chr12:121025894 G/A cg12219531 chr12:120966889 COQ5 0.54 11.42 0.41 1.31e-27 High light scatter reticulocyte count; BRCA cis rs72781680 1.000 rs72796351 chr2:24158425 T/C cg20701182 chr2:24300061 SF3B14 0.59 9.19 0.34 5.66e-19 Lymphocyte counts; BRCA cis rs4466137 0.953 rs6869030 chr5:83007311 C/T cg15083037 chr5:83017644 HAPLN1 -0.52 -10.52 -0.38 5.73e-24 Prostate cancer; BRCA cis rs68170813 0.559 rs77150993 chr7:106817100 G/T cg02696742 chr7:106810147 HBP1 -0.53 -8.49 -0.32 1.47e-16 Coronary artery disease; BRCA trans rs9650657 0.504 rs7813802 chr8:11033976 C/T cg08975724 chr8:8085496 FLJ10661 0.44 9.59 0.35 1.86e-20 Neuroticism; BRCA cis rs1865760 0.865 rs9467650 chr6:25958235 A/G cg16482183 chr6:26056742 HIST1H1C 0.5 10.34 0.38 2.88e-23 Height; BRCA cis rs6831352 0.918 rs17218073 chr4:100055739 G/A cg12011299 chr4:100065546 ADH4 -0.51 -11.73 -0.42 6.44e-29 Alcohol dependence; BRCA trans rs61931739 0.517 rs7975714 chr12:34055611 T/C cg13010199 chr12:38710504 ALG10B 0.5 9.57 0.35 2.29e-20 Morning vs. evening chronotype; BRCA cis rs796364 0.806 rs34381014 chr2:200916403 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs2549003 0.966 rs2070730 chr5:131819800 G/A cg21138405 chr5:131827807 IRF1 0.4 12.97 0.46 2.65e-34 Asthma (sex interaction); BRCA cis rs7615952 0.576 rs6804482 chr3:125815762 C/T cg06494592 chr3:125709126 NA -0.53 -8.23 -0.31 1.05e-15 Blood pressure (smoking interaction); BRCA cis rs9443645 0.527 rs4706743 chr6:79615793 G/T cg05283184 chr6:79620031 NA -0.35 -8.15 -0.31 1.9e-15 Intelligence (multi-trait analysis); BRCA cis rs9291683 0.588 rs35866697 chr4:10018604 C/A cg02734326 chr4:10020555 SLC2A9 0.4 8.84 0.33 9.03e-18 Bone mineral density; BRCA cis rs735860 0.687 rs2294852 chr6:53157214 C/G cg10236188 chr6:53219634 NA -0.4 -8.55 -0.32 9.02e-17 Glaucoma; BRCA cis rs2832077 0.943 rs2832091 chr21:30162855 C/T cg08807101 chr21:30365312 RNF160 -0.46 -7.94 -0.3 9e-15 Cognitive test performance; BRCA trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.54 -17.07 -0.56 4.02e-54 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.682 rs162379 chr21:44925334 A/G cg04455712 chr21:45112962 RRP1B -0.39 -10.37 -0.38 2.13e-23 Mean corpuscular volume; BRCA cis rs2739330 0.734 rs2000467 chr22:24241533 C/T cg16132339 chr22:24313637 DDTL;DDT -0.37 -8.03 -0.3 4.68e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs1949733 0.636 rs16842498 chr4:8539529 C/T cg11789530 chr4:8429930 ACOX3 -0.53 -12.3 -0.44 2.44e-31 Response to antineoplastic agents; BRCA cis rs637571 0.522 rs1786175 chr11:65754808 G/A cg17985854 chr11:65770987 BANF1;EIF1AD 0.4 9.62 0.36 1.51e-20 Eosinophil percentage of white cells; BRCA cis rs1580019 0.961 rs1580021 chr7:32497702 T/G cg07520158 chr7:32535189 LSM5;AVL9 0.39 8.5 0.32 1.33e-16 Cognitive ability; BRCA cis rs2153535 0.601 rs718504 chr6:8527512 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.77e-24 Motion sickness; BRCA cis rs9790314 0.934 rs462413 chr3:161101587 T/C cg04691961 chr3:161091175 C3orf57 -0.54 -12.32 -0.44 1.83e-31 Morning vs. evening chronotype; BRCA cis rs2075371 1.000 rs1868783 chr7:133975087 A/G cg11752832 chr7:134001865 SLC35B4 0.52 13.53 0.47 7.69e-37 Mean platelet volume; BRCA cis rs12887734 0.524 rs4900599 chr14:104283444 G/T cg26031613 chr14:104095156 KLC1 -0.55 -9.87 -0.36 1.69e-21 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs798554 0.610 rs2644297 chr7:2858906 A/C cg04166393 chr7:2884313 GNA12 0.42 9.09 0.34 1.23e-18 Height; BRCA cis rs867371 1.000 rs13380319 chr15:82506867 G/T cg00614314 chr15:82944287 LOC80154 0.42 8.9 0.33 5.82e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs8177253 0.965 rs4854762 chr3:133499063 A/G cg11941060 chr3:133502564 NA 0.47 11.5 0.41 5.85e-28 Iron status biomarkers; BRCA cis rs9393777 0.513 rs7759969 chr6:26663096 T/A cg07220782 chr6:26987966 LOC100270746;C6orf41 -0.3 -7.9 -0.3 1.19e-14 Intelligence (multi-trait analysis); BRCA cis rs2455601 0.744 rs11042133 chr11:8966511 A/C cg21881798 chr11:8931708 C11orf17;ST5 -0.48 -8.46 -0.32 1.78e-16 Schizophrenia; BRCA cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg06064525 chr11:970664 AP2A2 -0.49 -16.53 -0.55 2.2e-51 Alzheimer's disease (late onset); BRCA cis rs2204008 0.527 rs1315367 chr12:38177487 G/T cg26384229 chr12:38710491 ALG10B -0.45 -10.23 -0.38 7.69e-23 Bladder cancer; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg23708337 chr7:1209742 NA 0.49 8.1 0.31 2.8e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs6484504 0.532 rs1475558 chr11:31263428 A/G cg14844989 chr11:31128820 NA -0.43 -9.4 -0.35 9.95e-20 Red blood cell count; BRCA cis rs10465746 0.682 rs882897 chr1:84426049 A/T cg10977910 chr1:84465055 TTLL7 0.57 11.94 0.43 8.09e-30 Obesity-related traits; BRCA cis rs7618915 0.524 rs2028216 chr3:52680823 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.66 0.36 1.06e-20 Bipolar disorder; BRCA cis rs4803468 1.000 rs3213861 chr19:41919944 A/C cg09537434 chr19:41945824 ATP5SL -0.99 -23.27 -0.68 3.29e-87 Height; BRCA cis rs10504229 0.817 rs35207430 chr8:58167614 G/A cg14926445 chr8:58193284 C8orf71 -0.44 -8.58 -0.32 7.45e-17 Developmental language disorder (linguistic errors); BRCA cis rs1005277 0.602 rs1740743 chr10:38519222 C/T cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.03 -0.3 4.72e-15 Extrinsic epigenetic age acceleration; BRCA trans rs2204008 0.702 rs8175764 chr12:38363690 T/C cg06521331 chr12:34319734 NA -0.46 -8.52 -0.32 1.16e-16 Bladder cancer; BRCA cis rs798554 0.567 rs1182191 chr7:2869364 A/T cg13628971 chr7:2884303 GNA12 0.39 8.61 0.32 5.5e-17 Height; BRCA cis rs7851660 0.967 rs1443434 chr9:100617479 G/T cg13688889 chr9:100608707 NA -0.36 -8.7 -0.33 2.78e-17 Strep throat; BRCA cis rs2243480 0.708 rs13242216 chr7:65898277 T/C cg18252515 chr7:66147081 NA -1.07 -15.92 -0.53 2.69e-48 Diabetic kidney disease; BRCA cis rs1552244 0.882 rs28366039 chr3:10028988 C/A cg13047869 chr3:10149882 C3orf24 0.51 9.64 0.36 1.25e-20 Alzheimer's disease; BRCA cis rs68170813 0.559 rs6947675 chr7:106817184 T/C cg02696742 chr7:106810147 HBP1 -0.54 -8.91 -0.33 5.32e-18 Coronary artery disease; BRCA cis rs4363385 0.818 rs684305 chr1:153006242 G/A cg25856811 chr1:152973957 SPRR3 -0.32 -8.49 -0.32 1.49e-16 Inflammatory skin disease; BRCA cis rs6690583 1.000 rs6690583 chr1:85466337 A/G cg22153463 chr1:85462885 MCOLN2 -0.64 -11.75 -0.42 5.41e-29 Serum sulfate level; BRCA cis rs7903847 0.642 rs1537646 chr10:99149922 T/C cg20016023 chr10:99160130 RRP12 -0.27 -8.64 -0.32 4.5e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs13118159 0.550 rs11946956 chr4:1369094 T/G cg05025164 chr4:1340916 KIAA1530 0.77 15.38 0.52 1.16e-45 Longevity; BRCA cis rs2406342 0.528 rs75536638 chr18:74499060 G/T cg16472389 chr18:74514291 NA 0.47 10.12 0.37 1.98e-22 Adverse response to chemotherapy (neutropenia/leucopenia) (cisplatin); BRCA cis rs8031584 0.560 rs7171208 chr15:31198929 A/G cg14829155 chr15:31115871 NA 0.42 10.09 0.37 2.53e-22 Huntington's disease progression; BRCA cis rs3096299 0.967 rs2965935 chr16:89481274 C/T cg08392591 chr16:89556376 ANKRD11 -0.34 -7.99 -0.3 6.43e-15 Multiple myeloma (IgH translocation); BRCA cis rs7666738 0.830 rs4699597 chr4:99019031 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.82 0.39 3.64e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 0.953 rs114853497 chr8:58176176 A/T cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs7493 0.901 rs13226149 chr7:95025600 G/A cg19678392 chr7:94953810 PON1 -0.4 -8.17 -0.31 1.65e-15 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs7520050 0.966 rs1085243 chr1:46544768 C/T cg24296786 chr1:45957014 TESK2 0.41 9.19 0.34 5.42e-19 Red blood cell count;Reticulocyte count; BRCA cis rs6912958 0.559 rs369674 chr6:88043402 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.55 -11.58 -0.42 2.72e-28 Monocyte percentage of white cells; BRCA cis rs2197308 0.765 rs68029712 chr12:37906585 T/G cg26384229 chr12:38710491 ALG10B 0.77 17.07 0.56 4.14e-54 Morning vs. evening chronotype; BRCA cis rs873946 0.648 rs12783354 chr10:134557235 T/A cg26818010 chr10:134567672 INPP5A -0.78 -15.37 -0.52 1.39e-45 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs7474896 0.559 rs1735641 chr10:38184852 C/A cg25427524 chr10:38739819 LOC399744 0.55 9.72 0.36 6.48e-21 Obesity (extreme); BRCA cis rs4363385 0.818 rs2651413 chr1:153012068 T/A cg25856811 chr1:152973957 SPRR3 -0.33 -8.58 -0.32 7.47e-17 Inflammatory skin disease; BRCA cis rs34779708 0.931 rs55724039 chr10:35465397 A/G cg03585969 chr10:35415529 CREM 0.56 11.68 0.42 1.08e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs10751667 0.666 rs10794354 chr11:954615 A/T cg01483505 chr11:975446 AP2A2 0.33 8.9 0.33 5.62e-18 Alzheimer's disease (late onset); BRCA cis rs7772486 0.727 rs4896843 chr6:146063451 T/C cg05347473 chr6:146136440 FBXO30 -0.43 -8.57 -0.32 7.79e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4718428 1.000 rs4718428 chr7:66421446 T/G cg18252515 chr7:66147081 NA -0.42 -9.15 -0.34 7.85e-19 Corneal structure; BRCA cis rs10174077 0.687 rs10172023 chr2:152476028 C/G cg06191203 chr2:152266755 RIF1 -0.34 -9.0 -0.34 2.46e-18 Squamous cell lung carcinoma; BRCA cis rs2777491 0.957 rs2015781 chr15:41648967 C/G cg18705301 chr15:41695430 NDUFAF1 -0.62 -14.36 -0.49 9.47e-41 Ulcerative colitis; BRCA cis rs2882667 0.515 rs13161286 chr5:138484105 A/G cg04439458 chr5:138467593 SIL1 -0.46 -11.1 -0.4 2.69e-26 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs10129255 0.500 rs4774008 chr14:107137290 A/T cg07958169 chr14:107095056 NA -0.43 -9.09 -0.34 1.2e-18 Kawasaki disease; BRCA cis rs3812565 0.506 rs8413 chr9:139323311 T/C cg14169450 chr9:139327907 INPP5E 0.51 12.08 0.43 2.16e-30 Granulocyte percentage of myeloid white cells; BRCA cis rs1707322 0.716 rs28370457 chr1:46172062 C/T cg06784218 chr1:46089804 CCDC17 0.5 12.02 0.43 3.67e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs796364 0.951 rs281793 chr2:200847990 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 0.71 12.05 0.43 2.89e-30 Schizophrenia; BRCA cis rs4953318 0.619 rs12105417 chr2:46361255 A/C cg12428440 chr2:46370979 PRKCE 0.49 10.69 0.39 1.14e-24 Red blood cell count;Hematocrit;Red blood cell traits; BRCA cis rs10464366 0.544 rs9639812 chr7:39192058 C/T cg15212455 chr7:39170539 POU6F2 0.43 9.55 0.35 2.68e-20 IgG glycosylation; BRCA cis rs7707921 0.881 rs7733122 chr5:81351443 C/T cg15871215 chr5:81402204 ATG10 -0.39 -8.2 -0.31 1.32e-15 Breast cancer; BRCA cis rs875971 0.545 rs66594357 chr7:65792784 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 0.52 9.86 0.36 1.94e-21 Aortic root size; BRCA cis rs2276314 1.000 rs9956938 chr18:33567061 A/G cg05985134 chr18:33552581 C18orf21 0.61 11.01 0.4 6.47e-26 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs477895 0.838 rs11607007 chr11:64007976 C/T cg18225595 chr11:63971243 STIP1 0.5 8.89 0.33 6.26e-18 Mean platelet volume; BRCA cis rs9311474 0.508 rs12637627 chr3:52619962 G/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.88 -0.3 1.4e-14 Electroencephalogram traits; BRCA cis rs9527 0.615 rs36045108 chr10:104697929 G/A cg04362960 chr10:104952993 NT5C2 0.45 10.38 0.38 1.89e-23 Arsenic metabolism; BRCA cis rs7618501 0.516 rs2856236 chr3:50161717 A/C cg14019146 chr3:50243930 SLC38A3 0.34 7.89 0.3 1.31e-14 Intelligence (multi-trait analysis); BRCA cis rs1878931 0.624 rs1149492 chr16:3445239 A/G cg26668626 chr16:3451006 ZNF174;ZNF434 -0.61 -10.54 -0.38 4.62e-24 Body mass index (adult); BRCA cis rs6570726 0.516 rs10457779 chr6:145736663 C/T cg23711669 chr6:146136114 FBXO30 0.46 9.51 0.35 3.72e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs6540559 1.000 rs1044516 chr1:209959614 G/T cg25204440 chr1:209979598 IRF6 0.42 8.25 0.31 8.77e-16 Cleft lip with or without cleft palate; BRCA cis rs2576037 0.501 rs7245049 chr18:44528213 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.37 8.99 0.34 2.67e-18 Personality dimensions; BRCA cis rs11123170 0.543 rs4849178 chr2:113982608 C/T cg17445212 chr2:113993313 PAX8;LOC440839;LOC654433 0.49 8.09 0.3 2.96e-15 Renal function-related traits (BUN); BRCA cis rs4853012 0.838 rs6707729 chr2:74344685 G/A cg01017244 chr2:74357527 NA 0.57 13.29 0.47 9e-36 Gestational age at birth (maternal effect); BRCA trans rs9291683 0.588 rs13113730 chr4:10017628 C/T cg26043149 chr18:55253948 FECH 0.39 8.38 0.31 3.34e-16 Bone mineral density; BRCA cis rs2243480 1.000 rs906134 chr7:65444288 G/C cg18252515 chr7:66147081 NA -0.9 -12.92 -0.46 4.23e-34 Diabetic kidney disease; BRCA cis rs1215050 0.527 rs1214998 chr4:99042878 T/G cg05340658 chr4:99064831 C4orf37 0.48 11.17 0.4 1.35e-26 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs853679 0.607 rs34878803 chr6:28250179 T/C cg01620082 chr3:125678407 NA -0.83 -10.07 -0.37 2.97e-22 Depression; BRCA cis rs701145 0.537 rs357471 chr3:153896403 C/T cg17054900 chr3:154042577 DHX36 0.57 9.56 0.35 2.56e-20 Coronary artery disease; BRCA cis rs4927850 0.752 rs7618864 chr3:195749561 G/A cg12923728 chr3:195709715 SDHAP1 -0.6 -13.12 -0.46 5.69e-35 Pancreatic cancer; BRCA cis rs9473147 0.503 rs2171086 chr6:47590104 C/T cg12968598 chr6:47444699 CD2AP 0.44 9.63 0.36 1.38e-20 Platelet distribution width;Mean platelet volume; BRCA cis rs11252926 0.507 rs4881199 chr10:428090 C/G cg16386425 chr10:429943 DIP2C -0.44 -9.36 -0.35 1.33e-19 Psychosis in Alzheimer's disease; BRCA cis rs4363385 0.747 rs6671524 chr1:152974247 C/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.33 -0.35 1.69e-19 Inflammatory skin disease; BRCA cis rs2072499 0.931 rs1052053 chr1:156202173 A/G cg06970220 chr1:156163860 SLC25A44 0.35 8.87 0.33 7.14e-18 Testicular germ cell tumor; BRCA cis rs7246967 0.673 rs34126042 chr19:22909218 G/A cg23217946 chr19:22817039 ZNF492 0.5 9.12 0.34 9.65e-19 Bronchopulmonary dysplasia; BRCA cis rs2180341 0.814 rs9401958 chr6:127736357 T/G cg27446573 chr6:127587934 RNF146 0.69 15.82 0.53 8.25e-48 Breast cancer; BRCA cis rs17376456 0.825 rs13156202 chr5:93157721 C/T cg21475434 chr5:93447410 FAM172A -0.66 -8.58 -0.32 7.39e-17 Diabetic retinopathy; BRCA cis rs736408 0.812 rs1076425 chr3:52825462 A/G cg11041457 chr3:52719354 GNL3;PBRM1 0.29 8.9 0.33 5.67e-18 Bipolar disorder; BRCA cis rs34779708 0.733 rs4391768 chr10:35547595 A/G cg03585969 chr10:35415529 CREM 0.44 9.1 0.34 1.17e-18 Inflammatory bowel disease;Crohn's disease; BRCA cis rs6942756 1.000 rs6971917 chr7:128976919 G/A cg02491457 chr7:128862824 NA -0.71 -14.05 -0.49 3e-39 White matter hyperintensity burden; BRCA cis rs4853036 1.000 rs12614581 chr2:70079400 C/G cg02498382 chr2:70120550 SNRNP27 -0.49 -9.04 -0.34 1.85e-18 Colorectal or endometrial cancer; BRCA trans rs11764590 0.585 rs11772463 chr7:2078132 A/C cg25206134 chr2:45395956 NA 0.5 7.94 0.3 8.92e-15 Neuroticism; BRCA cis rs13191362 0.935 rs66507030 chr6:162953825 G/A cg14584255 chr6:163149320 PACRG;PARK2 0.5 8.07 0.3 3.55e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9790314 1.000 rs6765269 chr3:160948542 T/C cg04691961 chr3:161091175 C3orf57 -0.58 -13.51 -0.47 9.25e-37 Morning vs. evening chronotype; BRCA cis rs10197940 0.624 rs4461258 chr2:152429679 A/G cg19508488 chr2:152266495 RIF1 -0.51 -10.37 -0.38 2.1e-23 Lung cancer; BRCA cis rs2153535 0.580 rs9393033 chr6:8521446 G/A cg07606381 chr6:8435919 SLC35B3 0.66 14.55 0.5 1.27e-41 Motion sickness; BRCA cis rs595982 0.559 rs4802516 chr19:49366170 T/C cg15549821 chr19:49342101 PLEKHA4 -0.7 -11.47 -0.41 7.65e-28 Red cell distribution width; BRCA cis rs736408 0.634 rs11717836 chr3:52807736 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.27 -0.31 7.85e-16 Bipolar disorder; BRCA cis rs2882667 0.690 rs185956 chr5:138230263 A/G cg04439458 chr5:138467593 SIL1 -0.34 -8.28 -0.31 7.37e-16 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs3806843 0.766 rs2251860 chr5:140048209 T/C cg16179182 chr5:140090404 VTRNA1-1 0.42 9.69 0.36 7.95e-21 Depressive symptoms (multi-trait analysis); BRCA cis rs7833986 1.000 rs36088882 chr8:57092914 T/A cg23139584 chr8:56987506 RPS20;SNORD54 0.46 8.22 0.31 1.12e-15 Height; BRCA cis rs7572733 0.534 rs1401091 chr2:198790423 T/G cg00792783 chr2:198669748 PLCL1 -0.46 -10.01 -0.37 5.34e-22 Dermatomyositis; BRCA cis rs2153535 0.580 rs969422 chr6:8451780 A/T cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs2153535 0.580 rs1120392 chr6:8487053 C/A cg21535247 chr6:8435926 SLC35B3 0.41 9.28 0.34 2.61e-19 Motion sickness; BRCA trans rs61931739 0.500 rs11053272 chr12:34547020 C/G cg13010199 chr12:38710504 ALG10B 0.5 9.83 0.36 2.4e-21 Morning vs. evening chronotype; BRCA cis rs68170813 0.523 rs12535093 chr7:107020182 C/T cg02696742 chr7:106810147 HBP1 -0.5 -8.43 -0.32 2.38e-16 Coronary artery disease; BRCA cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg11752832 chr7:134001865 SLC35B4 0.52 13.46 0.47 1.53e-36 Mean platelet volume; BRCA cis rs6762 0.748 rs1130663 chr11:837582 G/A cg06085985 chr11:830527 EFCAB4A -0.41 -8.99 -0.33 2.87e-18 Mean platelet volume; BRCA cis rs6089829 0.851 rs6089827 chr20:61668845 C/T cg02544614 chr20:61657117 NA 0.28 8.04 0.3 4.32e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs3749237 0.595 rs1050088 chr3:49570882 C/T cg07636037 chr3:49044803 WDR6 -0.53 -11.64 -0.42 1.49e-28 Resting heart rate; BRCA cis rs16854884 0.584 rs34372603 chr3:143738249 T/C cg06585982 chr3:143692056 C3orf58 0.42 8.93 0.33 4.41e-18 Economic and political preferences (feminism/equality); BRCA cis rs965469 1.000 rs6051764 chr20:3321807 A/G cg25506879 chr20:3388711 C20orf194 0.5 9.87 0.36 1.81e-21 IFN-related cytopenia; BRCA cis rs2404602 1.000 rs2056544 chr15:76826003 G/A cg23625390 chr15:77176239 SCAPER 0.44 11.17 0.4 1.35e-26 Blood metabolite levels; BRCA cis rs1635 0.826 rs4711167 chr6:28294888 C/T cg15743358 chr6:28303923 ZNF323 0.7 7.96 0.3 8.09e-15 Schizophrenia; BRCA cis rs11051970 0.636 rs2651368 chr12:32561506 T/C cg24626660 chr12:32551988 NA 0.31 9.26 0.34 2.98e-19 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs2354432 0.607 rs10900350 chr1:146828017 T/G cg25205988 chr1:146714368 CHD1L 0.88 12.48 0.44 3.69e-32 Mitochondrial DNA levels; BRCA cis rs1113500 1.000 rs1113500 chr1:108595442 G/T cg06207961 chr1:108661230 NA -0.44 -10.46 -0.38 9.38e-24 Growth-regulated protein alpha levels; BRCA cis rs4975616 0.836 rs460073 chr5:1336459 T/C cg06550200 chr5:1325588 CLPTM1L -0.66 -14.28 -0.49 2.27e-40 Lung cancer; BRCA cis rs2276314 0.857 rs28651028 chr18:33638910 G/A cg19628046 chr18:33552617 C18orf21 0.52 10.7 0.39 1.12e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs2153535 0.562 rs10458225 chr6:8386004 G/A cg21535247 chr6:8435926 SLC35B3 -0.37 -8.24 -0.31 9.62e-16 Motion sickness; BRCA cis rs4665809 0.590 rs35746418 chr2:26455002 C/G cg04944784 chr2:26401820 FAM59B 0.95 16.17 0.54 1.43e-49 Gut microbiome composition (summer); BRCA cis rs10504229 1.000 rs67913746 chr8:58177825 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.59 -0.32 6.46e-17 Developmental language disorder (linguistic errors); BRCA cis rs12142240 0.698 rs72677587 chr1:46813982 G/A cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs35110281 0.627 rs1595167 chr21:44965874 T/G cg01579765 chr21:45077557 HSF2BP -0.34 -8.87 -0.33 7.01e-18 Mean corpuscular volume; BRCA cis rs6570726 0.599 rs455001 chr6:145854450 A/T cg13319975 chr6:146136371 FBXO30 -0.61 -13.7 -0.48 1.28e-37 Lobe attachment (rater-scored or self-reported); BRCA cis rs2115630 1.000 rs11854313 chr15:85304048 G/C cg11189052 chr15:85197271 WDR73 -0.33 -7.99 -0.3 6.37e-15 P wave terminal force; BRCA cis rs965469 0.779 rs2236088 chr20:3256342 T/C cg25506879 chr20:3388711 C20orf194 -0.45 -9.1 -0.34 1.12e-18 IFN-related cytopenia; BRCA cis rs9858542 0.953 rs11715915 chr3:49455330 A/G cg03060546 chr3:49711283 APEH 0.55 10.57 0.39 3.69e-24 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA trans rs1493916 1.000 rs990882 chr18:31398180 T/G cg15819921 chr19:927150 ARID3A -0.48 -9.17 -0.34 6.67e-19 Life satisfaction; BRCA cis rs9399135 0.967 rs6919862 chr6:135352443 C/A cg24558204 chr6:135376177 HBS1L 0.46 12.39 0.44 9.78e-32 Red blood cell count; BRCA cis rs9400271 0.632 rs949882 chr6:109586062 A/G cg01475377 chr6:109611718 NA 0.42 10.16 0.37 1.43e-22 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs4555082 0.957 rs2816629 chr14:105737261 G/A cg06808227 chr14:105710500 BRF1 -0.74 -15.16 -0.51 1.39e-44 Mean platelet volume;Platelet distribution width; BRCA cis rs4535700 0.501 rs57251705 chr7:55981083 A/G cg09872392 chr7:56161020 PHKG1 0.35 8.04 0.3 4.43e-15 Macular telangiectasia type 2; BRCA cis rs11051970 0.879 rs2651363 chr12:32587550 G/T cg02745156 chr12:32552066 NA -0.26 -8.6 -0.32 6.07e-17 Response to tocilizumab in rheumatoid arthritis; BRCA cis rs6121246 0.909 rs6060679 chr20:30270772 C/G cg21427119 chr20:30132790 HM13 0.42 8.92 0.33 4.92e-18 Mean corpuscular hemoglobin; BRCA cis rs838147 0.760 rs12979144 chr19:49237547 G/A cg13540341 chr19:49222985 MAMSTR 0.34 9.18 0.34 5.71e-19 Dietary macronutrient intake; BRCA cis rs35306767 0.903 rs4522091 chr10:874116 G/T cg26597838 chr10:835615 NA 1.02 17.81 0.58 6.25e-58 Eosinophil percentage of granulocytes; BRCA trans rs2235573 0.625 rs8142174 chr22:38427963 C/T cg19894588 chr14:64061835 NA 0.33 7.96 0.3 7.76e-15 Glioblastoma;Glioma; BRCA cis rs9790314 0.638 rs6441339 chr3:160619683 T/G cg03342759 chr3:160939853 NMD3 0.44 8.86 0.33 7.58e-18 Morning vs. evening chronotype; BRCA trans rs3858145 0.588 rs76854765 chr10:70037456 C/T cg04882175 chr6:131122610 NA -0.34 -8.23 -0.31 1.08e-15 Optic nerve measurement (disc area);Optic cup area;Optic nerve measurement (cup area); BRCA cis rs2278034 0.578 rs881753 chr3:195606770 C/T cg00031303 chr3:195681400 NA -0.4 -8.44 -0.32 2.11e-16 Bronchopulmonary dysplasia; BRCA cis rs6687430 0.562 rs12139169 chr1:10635328 C/T cg17425144 chr1:10567563 PEX14 0.5 11.61 0.42 2.18e-28 Hand grip strength; BRCA cis rs12477438 0.520 rs13031919 chr2:99848932 A/T cg26064155 chr2:99771622 LIPT1;TSGA10 0.71 18.88 0.6 1.66e-63 Chronic sinus infection; BRCA cis rs11992186 0.505 rs7845203 chr8:8145440 A/G cg06636001 chr8:8085503 FLJ10661 0.59 13.21 0.46 2.18e-35 Neuroticism; BRCA cis rs8177253 1.000 rs6439439 chr3:133481498 G/T cg16414030 chr3:133502952 NA -0.47 -11.1 -0.4 2.73e-26 Iron status biomarkers; BRCA cis rs9733 0.596 rs12085275 chr1:150650265 T/C cg17724175 chr1:150552817 MCL1 0.25 8.33 0.31 4.95e-16 Tonsillectomy; BRCA cis rs11971779 0.680 rs7799598 chr7:139051833 C/T cg07862535 chr7:139043722 LUC7L2 0.38 10.28 0.38 4.63e-23 Diisocyanate-induced asthma; BRCA cis rs1595825 0.891 rs6707521 chr2:198713231 A/G cg19156104 chr2:198669113 PLCL1 0.45 8.32 0.31 5.29e-16 Ulcerative colitis; BRCA cis rs2635047 0.967 rs2684820 chr18:44664304 G/A cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.39 8.46 0.32 1.76e-16 Educational attainment; BRCA cis rs950776 0.593 rs621849 chr15:78872861 G/A cg06917634 chr15:78832804 PSMA4 -0.57 -12.79 -0.45 1.65e-33 Sudden cardiac arrest; BRCA cis rs7582180 0.629 rs4850927 chr2:100969067 A/G cg14675211 chr2:100938903 LONRF2 0.46 10.46 0.38 9.25e-24 Intelligence (multi-trait analysis); BRCA cis rs6951245 1.000 rs76129108 chr7:1089159 G/A cg03188948 chr7:1209495 NA 0.86 11.78 0.42 3.91e-29 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10256972 0.577 rs2949179 chr7:1209885 C/G cg18402987 chr7:1209562 NA 0.65 14.8 0.51 7.44e-43 Longevity;Endometriosis; BRCA cis rs3796619 1.000 rs55741287 chr4:1094670 T/C cg27284194 chr4:1044797 NA 0.43 9.24 0.34 3.55e-19 Recombination rate (males); BRCA cis rs7552404 0.765 rs211717 chr1:76106969 G/A cg10523679 chr1:76189770 ACADM -0.76 -16.11 -0.54 2.86e-49 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7481584 0.581 rs399565 chr11:3061780 C/T cg08508325 chr11:3079039 CARS 0.28 8.46 0.32 1.77e-16 Calcium levels; BRCA cis rs7618915 0.531 rs77146033 chr3:52701501 G/T cg18404041 chr3:52824283 ITIH1 -0.41 -12.17 -0.43 8.58e-31 Bipolar disorder; BRCA cis rs7927771 0.524 rs7129797 chr11:47667167 G/C cg20307385 chr11:47447363 PSMC3 0.42 9.51 0.35 3.9e-20 Subjective well-being; BRCA cis rs6964587 0.967 rs10953065 chr7:91808915 A/G cg17063962 chr7:91808500 NA -0.55 -12.09 -0.43 1.9e-30 Breast cancer; BRCA cis rs4665809 0.818 rs35413760 chr2:26267137 C/A cg04944784 chr2:26401820 FAM59B 0.8 11.11 0.4 2.45e-26 Gut microbiome composition (summer); BRCA cis rs9942416 0.601 rs40059 chr5:74964582 A/G cg19683494 chr5:74908142 NA -0.45 -8.42 -0.32 2.57e-16 Age-related disease endophenotypes; BRCA cis rs7772486 0.536 rs9373467 chr6:145955605 C/T cg13319975 chr6:146136371 FBXO30 -0.6 -13.11 -0.46 6.35e-35 Lobe attachment (rater-scored or self-reported); BRCA cis rs1801251 1.000 rs778166 chr2:233664097 A/T cg08000102 chr2:233561755 GIGYF2 0.62 13.46 0.47 1.48e-36 Coronary artery disease; BRCA cis rs798554 0.757 rs1183085 chr7:2875570 G/A cg14863265 chr7:2801509 GNA12 -0.45 -9.6 -0.36 1.74e-20 Height; BRCA cis rs7590720 1.000 rs4674051 chr2:216907512 G/C cg12620499 chr2:216877984 MREG 0.79 22.46 0.66 8.6e-83 Alcohol dependence; BRCA trans rs60843830 1.000 rs62114548 chr2:274672 C/G cg11347411 chr7:150020925 ACTR3C;LRRC61 0.67 14.63 0.5 5.38e-42 Spherical equivalent (joint analysis main effects and education interaction); BRCA cis rs9287719 0.967 rs7600820 chr2:10740044 A/G cg02196655 chr2:10830764 NOL10 -0.3 -8.03 -0.3 4.84e-15 Prostate cancer; BRCA cis rs7772486 0.790 rs2265472 chr6:146220758 G/C cg23711669 chr6:146136114 FBXO30 0.75 17.43 0.57 6.04e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs2303759 0.709 rs10422677 chr19:49824290 C/T cg22307029 chr19:49891270 CCDC155 0.53 8.83 0.33 1.04e-17 Multiple sclerosis; BRCA cis rs2806561 1.000 rs2806558 chr1:23503456 T/C cg19743168 chr1:23544995 NA 0.4 9.6 0.36 1.74e-20 Height; BRCA cis rs1862618 0.525 rs2662021 chr5:56261691 C/T cg24531977 chr5:56204891 C5orf35 0.99 20.06 0.62 8.25e-70 Initial pursuit acceleration; BRCA cis rs12142240 0.698 rs66575205 chr1:46814092 T/G cg14993813 chr1:46806288 NSUN4 -0.48 -9.17 -0.34 6.63e-19 Menopause (age at onset); BRCA cis rs2070488 0.775 rs6599204 chr3:38525734 C/T cg24069376 chr3:38537580 EXOG 0.31 8.7 0.33 2.85e-17 Electrocardiographic conduction measures; BRCA cis rs9811920 0.898 rs7636776 chr3:99840446 T/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.53 12.53 0.44 2.29e-32 Axial length; BRCA cis rs7766436 0.767 rs7764914 chr6:22601548 T/G cg13666174 chr6:22585274 NA -0.37 -9.48 -0.35 4.99e-20 Coronary artery disease; BRCA cis rs1215050 0.791 rs6813619 chr4:98830768 C/T cg05340658 chr4:99064831 C4orf37 -0.44 -10.19 -0.37 1.06e-22 Waist-to-hip ratio adjusted for body mass index; BRCA cis rs8031584 0.723 rs11632229 chr15:31179534 A/G cg14829155 chr15:31115871 NA 0.51 13.06 0.46 9.68e-35 Huntington's disease progression; BRCA cis rs780096 0.526 rs780107 chr2:27684734 A/G cg21248554 chr2:27665150 KRTCAP3 -0.37 -9.53 -0.35 3.1e-20 Total body bone mineral density; BRCA cis rs12477438 0.798 rs7570657 chr2:99654281 G/C cg08885076 chr2:99613938 TSGA10 -0.52 -11.8 -0.42 3.27e-29 Chronic sinus infection; BRCA cis rs2243480 1.000 rs1964692 chr7:65454183 G/A cg18252515 chr7:66147081 NA -0.88 -12.63 -0.45 8.19e-33 Diabetic kidney disease; BRCA cis rs11920090 0.932 rs2292622 chr3:170723664 A/G cg09710316 chr3:170744871 SLC2A2 0.41 7.89 0.3 1.31e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction);Homeostasis model assessment of beta-cell function; BRCA cis rs3096299 0.967 rs2911256 chr16:89485096 G/C cg08822215 chr16:89438651 ANKRD11 -0.4 -8.58 -0.32 6.96e-17 Multiple myeloma (IgH translocation); BRCA cis rs1005277 0.522 rs289649 chr10:37975384 T/C cg00409905 chr10:38381863 ZNF37A -0.47 -9.96 -0.37 7.99e-22 Extrinsic epigenetic age acceleration; BRCA cis rs2836974 0.899 rs34176878 chr21:40548855 C/A cg11644478 chr21:40555479 PSMG1 0.84 19.34 0.61 6.13e-66 Cognitive function; BRCA cis rs7959452 0.590 rs6581889 chr12:69757429 T/C cg20891283 chr12:69753455 YEATS4 0.73 21.96 0.66 4.86e-80 Blood protein levels; BRCA trans rs12310956 0.532 rs1352209 chr12:33983408 G/A cg26384229 chr12:38710491 ALG10B 0.51 11.03 0.4 4.98e-26 Morning vs. evening chronotype; BRCA cis rs796364 0.755 rs203762 chr2:200905136 C/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.72 -11.12 -0.4 2.2e-26 Schizophrenia; BRCA cis rs10504229 0.654 rs903705 chr8:58128185 T/A cg08219700 chr8:58056026 NA 0.45 8.35 0.31 4.18e-16 Developmental language disorder (linguistic errors); BRCA cis rs9790314 0.637 rs778643 chr3:160706041 G/A cg03342759 chr3:160939853 NMD3 -0.46 -8.84 -0.33 9.06e-18 Morning vs. evening chronotype; BRCA cis rs1707322 0.717 rs2991988 chr1:46082431 C/A cg03146154 chr1:46216737 IPP -0.5 -11.01 -0.4 6.25e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs67478160 0.654 rs1997913 chr14:104213960 C/T cg08213375 chr14:104286397 PPP1R13B 0.64 18.2 0.58 6.11e-60 Schizophrenia; BRCA cis rs9399135 1.000 rs1014021 chr6:135334600 C/T cg24558204 chr6:135376177 HBS1L -0.44 -12.13 -0.43 1.23e-30 Red blood cell count; BRCA cis rs10504229 0.683 rs73603877 chr8:58108428 C/T cg24829409 chr8:58192753 C8orf71 -0.48 -9.25 -0.34 3.23e-19 Developmental language disorder (linguistic errors); BRCA cis rs798554 0.797 rs798493 chr7:2798731 A/G cg14863265 chr7:2801509 GNA12 -0.48 -10.57 -0.39 3.71e-24 Height; BRCA cis rs2032447 0.702 rs199753 chr6:26001888 G/A cg03517284 chr6:25882590 NA -0.52 -10.59 -0.39 3.05e-24 Intelligence (multi-trait analysis); BRCA cis rs875971 0.825 rs801202 chr7:66023929 C/T cg11764359 chr7:65958608 NA -0.76 -16.79 -0.55 1.17e-52 Aortic root size; BRCA cis rs35110281 0.744 rs230646 chr21:44918788 A/G cg04455712 chr21:45112962 RRP1B 0.4 10.44 0.38 1.19e-23 Mean corpuscular volume; BRCA cis rs7552404 0.924 rs1498317 chr1:76171984 A/C cg22875332 chr1:76189707 ACADM 0.8 19.06 0.6 1.81e-64 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9911578 1.000 rs4793952 chr17:56608465 C/T cg05425664 chr17:57184151 TRIM37 0.39 9.59 0.35 1.97e-20 Intelligence (multi-trait analysis); BRCA cis rs1865760 0.566 rs10807006 chr6:26048752 C/A cg16482183 chr6:26056742 HIST1H1C 0.56 11.86 0.42 1.79e-29 Height; BRCA cis rs7589728 0.563 rs79892776 chr2:88470593 G/A cg14558114 chr2:88469736 THNSL2 0.63 9.13 0.34 8.88e-19 Plasma clusterin levels; BRCA cis rs2073300 1.000 rs6132626 chr20:23444672 T/C cg12062639 chr20:23401060 NAPB 0.89 10.63 0.39 2.06e-24 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs12711979 0.509 rs13000873 chr2:3823705 T/C cg17052675 chr2:3827356 NA -0.7 -23.81 -0.69 3.44e-90 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs6740322 0.895 rs10172375 chr2:43572047 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.66 -12.36 -0.44 1.32e-31 Coronary artery disease; BRCA cis rs1008375 1.000 rs10032326 chr4:17630717 A/T cg16339924 chr4:17578868 LAP3 0.63 15.75 0.53 1.77e-47 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10504229 0.906 rs58251024 chr8:58172259 G/C cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 5.83e-21 Developmental language disorder (linguistic errors); BRCA trans rs1005277 0.579 rs2474587 chr10:38420666 C/T cg17830980 chr10:43048298 ZNF37B -0.56 -13.72 -0.48 9.54e-38 Extrinsic epigenetic age acceleration; BRCA cis rs12926788 0.542 rs11862971 chr16:24767574 C/A cg06028605 chr16:24865363 SLC5A11 0.46 10.09 0.37 2.6e-22 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs7072216 0.727 rs7901577 chr10:100164442 A/G cg26618903 chr10:100175079 PYROXD2 -0.31 -8.67 -0.32 3.68e-17 Metabolite levels; BRCA trans rs3780486 0.834 rs75443249 chr9:33149207 A/G cg20290983 chr6:43655470 MRPS18A 0.94 21.38 0.65 6.59e-77 IgG glycosylation; BRCA cis rs769267 0.930 rs9917108 chr19:19572785 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.36 8.03 0.3 4.62e-15 Tonsillectomy; BRCA cis rs61931739 0.500 rs12832312 chr12:34031199 G/A cg06521331 chr12:34319734 NA -0.62 -11.28 -0.41 5.11e-27 Morning vs. evening chronotype; BRCA cis rs780096 0.526 rs7594812 chr2:27611469 A/G cg12648201 chr2:27665141 KRTCAP3 -0.35 -8.5 -0.32 1.31e-16 Total body bone mineral density; BRCA cis rs7098414 0.511 rs4934126 chr10:82151598 A/G cg00277334 chr10:82204260 NA -0.49 -10.31 -0.38 3.77e-23 Post bronchodilator FEV1; BRCA cis rs2635047 0.905 rs7504798 chr18:44610879 A/G cg19077165 chr18:44547161 KATNAL2 -0.44 -9.11 -0.34 1.01e-18 Educational attainment; BRCA cis rs477895 0.713 rs1059440 chr11:63991801 C/T cg23719950 chr11:63933701 MACROD1 0.57 9.75 0.36 4.94e-21 Mean platelet volume; BRCA trans rs11098499 0.909 rs9759478 chr4:120367998 G/A cg19731845 chr4:166199412 KLHL2;GK3P 0.35 8.0 0.3 5.99e-15 Corneal astigmatism; BRCA cis rs7103648 0.695 rs6485758 chr11:47530024 G/A cg03711944 chr11:47377212 SPI1 -0.4 -9.64 -0.36 1.27e-20 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs4925386 1.000 rs1889201 chr20:60923075 C/T cg24112000 chr20:60950667 NA 0.52 11.2 0.41 1.01e-26 Colorectal cancer;Colorectal cancer (SNP x SNP interaction); BRCA cis rs2739330 0.760 rs1002286 chr22:24257337 A/G cg24846343 chr22:24311635 DDTL -0.58 -14.86 -0.51 4.11e-43 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs61931739 0.500 rs11053066 chr12:34185318 G/A cg13010199 chr12:38710504 ALG10B 0.49 9.62 0.36 1.5e-20 Morning vs. evening chronotype; BRCA trans rs9467711 0.659 rs36033628 chr6:26456074 T/G cg01620082 chr3:125678407 NA -0.7 -8.26 -0.31 8.19e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs66887589 0.934 rs7681980 chr4:120533223 G/A cg09307838 chr4:120376055 NA -0.44 -9.08 -0.34 1.3e-18 Diastolic blood pressure; BRCA cis rs2549003 0.966 rs2706385 chr5:131831766 T/G cg21138405 chr5:131827807 IRF1 -0.39 -12.6 -0.45 1.12e-32 Asthma (sex interaction); BRCA cis rs2153535 0.580 rs7743995 chr6:8496212 A/G cg21535247 chr6:8435926 SLC35B3 0.42 9.52 0.35 3.54e-20 Motion sickness; BRCA cis rs9649213 0.593 rs13246843 chr7:98002661 G/T cg24562669 chr7:97807699 LMTK2 0.46 12.18 0.43 7.51e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs6750047 0.932 rs2116232 chr2:38268718 C/A cg07380506 chr2:38303506 CYP1B1 0.42 9.79 0.36 3.48e-21 Cutaneous malignant melanoma;Melanoma; BRCA cis rs7520050 0.808 rs11211195 chr1:46282295 T/C cg24296786 chr1:45957014 TESK2 0.44 9.83 0.36 2.51e-21 Red blood cell count;Reticulocyte count; BRCA cis rs9473147 0.516 rs6931478 chr6:47461913 C/A cg12968598 chr6:47444699 CD2AP 0.44 9.7 0.36 7.62e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs2455799 0.574 rs2455800 chr3:15701589 T/G cg16303742 chr3:15540471 COLQ -0.35 -8.49 -0.32 1.4e-16 Mean platelet volume; BRCA cis rs10256972 0.758 rs9801444 chr7:1080444 A/C cg04025307 chr7:1156635 C7orf50 -0.55 -12.69 -0.45 4.5e-33 Longevity;Endometriosis; BRCA cis rs16866061 1.000 rs72974205 chr2:225408468 C/T cg12698349 chr2:225449008 CUL3 0.79 20.58 0.63 1.38e-72 Acute graft versus host disease in bone marrow transplantation (recipient effect); BRCA cis rs4665809 0.549 rs72809635 chr2:26411674 G/A cg22920501 chr2:26401640 FAM59B 0.9 13.73 0.48 9.17e-38 Gut microbiome composition (summer); BRCA cis rs757110 0.705 rs10832778 chr11:17394073 C/G cg03864215 chr11:17408437 KCNJ11 -0.27 -7.98 -0.3 7e-15 Type 2 diabetes; BRCA cis rs9443645 0.901 rs6454092 chr6:79701972 G/A cg18132916 chr6:79620363 NA -0.48 -10.93 -0.4 1.31e-25 Intelligence (multi-trait analysis); BRCA trans rs61931739 0.534 rs12372721 chr12:34175301 C/T cg26384229 chr12:38710491 ALG10B 0.69 14.64 0.5 4.65e-42 Morning vs. evening chronotype; BRCA cis rs270601 0.710 rs371709 chr5:131583240 A/G cg12564285 chr5:131593104 PDLIM4 0.38 9.67 0.36 1e-20 Acylcarnitine levels; BRCA cis rs7044106 0.762 rs4142158 chr9:123410819 C/T cg09586646 chr9:123605570 PSMD5;LOC253039 0.58 11.99 0.43 5.21e-30 Hip circumference adjusted for BMI; BRCA cis rs7772486 0.846 rs7755440 chr6:146375906 T/C cg05347473 chr6:146136440 FBXO30 0.4 7.94 0.3 9.43e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs208520 0.690 rs12198745 chr6:66722598 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.94 19.85 0.62 1.19e-68 Exhaled nitric oxide output; BRCA cis rs7786808 0.741 rs35059736 chr7:158224692 C/T cg01191920 chr7:158217561 PTPRN2 -0.45 -10.42 -0.38 1.4e-23 Obesity-related traits; BRCA cis rs929596 0.517 rs1875263 chr2:234625622 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.42 -10.87 -0.4 2.2e-25 Total bilirubin levels in HIV-1 infection; BRCA cis rs7631605 0.608 rs62239460 chr3:37442910 A/G cg15934958 chr3:37212084 LRRFIP2 0.38 7.85 0.3 1.77e-14 Cerebrospinal P-tau181p levels; BRCA trans rs61931739 0.817 rs304313 chr12:34216898 C/T cg26384229 chr12:38710491 ALG10B 0.44 10.72 0.39 8.67e-25 Morning vs. evening chronotype; BRCA trans rs3733585 0.699 rs4276278 chr4:9948870 T/C cg26043149 chr18:55253948 FECH -0.36 -7.92 -0.3 1.05e-14 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs586533 0.813 rs1790262 chr11:99495651 T/A cg22878054 chr11:99397252 CNTN5 0.31 7.81 0.3 2.39e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs4481887 0.927 rs4345830 chr1:248474845 G/C cg00666640 chr1:248458726 OR2T12 0.3 8.42 0.32 2.5e-16 Common traits (Other); BRCA cis rs11098499 0.913 rs35271032 chr4:120156659 C/T cg09307838 chr4:120376055 NA 0.61 11.98 0.43 5.74e-30 Corneal astigmatism; BRCA cis rs7618915 0.571 rs34954168 chr3:52612159 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.48 10.07 0.37 3.06e-22 Bipolar disorder; BRCA cis rs12530845 0.887 rs73725434 chr7:135313657 T/C cg23117316 chr7:135346802 PL-5283 -0.35 -8.37 -0.31 3.66e-16 Red blood cell traits; BRCA cis rs1862618 0.671 rs2591957 chr5:56243146 A/T cg24531977 chr5:56204891 C5orf35 0.71 15.67 0.53 4.4e-47 Initial pursuit acceleration; BRCA cis rs11971779 0.838 rs58074268 chr7:139108925 C/T cg07862535 chr7:139043722 LUC7L2 0.43 11.54 0.42 3.99e-28 Diisocyanate-induced asthma; BRCA cis rs10504229 0.728 rs17804822 chr8:58156276 T/C cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs1580019 0.523 rs13236410 chr7:32690663 G/A cg14728415 chr7:32535168 LSM5;AVL9 0.38 8.33 0.31 4.85e-16 Cognitive ability; BRCA cis rs7772486 0.686 rs9390348 chr6:146044748 C/T cg23711669 chr6:146136114 FBXO30 -0.71 -16.94 -0.56 2e-53 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649213 0.593 rs7803372 chr7:97992257 A/G cg01877450 chr7:97915802 BRI3 -0.39 -8.86 -0.33 7.95e-18 Prostate cancer (SNP x SNP interaction); BRCA cis rs6951245 0.554 rs75075857 chr7:1140298 C/T cg23708337 chr7:1209742 NA 0.48 8.15 0.31 1.94e-15 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4363385 0.818 rs1750309 chr1:153013630 G/C cg24667326 chr1:152973720 SPRR3 -0.32 -8.51 -0.32 1.22e-16 Inflammatory skin disease; BRCA cis rs3772130 0.961 rs11716984 chr3:121362407 A/T cg01951420 chr3:121553821 IQCB1;EAF2 0.54 9.5 0.35 4.22e-20 Cognitive performance; BRCA cis rs7833986 0.501 rs9650314 chr8:56903610 G/A cg23139584 chr8:56987506 RPS20;SNORD54 0.68 12.57 0.45 1.6e-32 Height; BRCA cis rs9649213 0.593 rs7807555 chr7:97957517 G/A cg01877450 chr7:97915802 BRI3 -0.38 -8.56 -0.32 8.45e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs6973256 0.897 rs763644 chr7:133343349 G/C cg07491979 chr7:133331646 EXOC4 -0.39 -9.03 -0.34 2.04e-18 Intelligence (multi-trait analysis); BRCA cis rs12048904 0.505 rs4517368 chr1:101255052 C/T cg00063077 chr1:101360652 SLC30A7;EXTL2 -0.65 -14.59 -0.5 7.82e-42 Multiple sclerosis; BRCA cis rs4665809 1.000 rs6546726 chr2:26275116 A/G cg26314531 chr2:26401878 FAM59B -0.65 -11.19 -0.4 1.1e-26 Gut microbiome composition (summer); BRCA cis rs1552244 0.882 rs55840655 chr3:10042690 C/T cg00149659 chr3:10157352 C3orf10 0.72 12.57 0.45 1.49e-32 Alzheimer's disease; BRCA cis rs9393692 0.905 rs6908328 chr6:26292855 C/A cg13736514 chr6:26305472 NA -0.37 -12.59 -0.45 1.29e-32 Educational attainment; BRCA cis rs875971 0.862 rs1643375 chr7:65872677 T/C cg18876405 chr7:65276391 NA 0.52 11.65 0.42 1.43e-28 Aortic root size; BRCA cis rs2882667 0.824 rs1560656 chr5:138470789 A/G cg04439458 chr5:138467593 SIL1 0.42 10.74 0.39 7.69e-25 Age-related hearing impairment (SNP x SNP interaction); BRCA cis rs4862750 0.872 rs6825289 chr4:187879109 T/G cg03452623 chr4:187889614 NA -0.32 -10.37 -0.38 2.09e-23 Lobe attachment (rater-scored or self-reported); BRCA cis rs7666738 0.830 rs13122054 chr4:98972974 G/A cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs6120849 0.901 rs6088735 chr20:33745676 C/T cg24642439 chr20:33292090 TP53INP2 0.47 8.45 0.32 1.99e-16 Protein C levels; BRCA cis rs1005277 0.579 rs1740749 chr10:38521646 A/G cg00409905 chr10:38381863 ZNF37A -0.53 -11.35 -0.41 2.61e-27 Extrinsic epigenetic age acceleration; BRCA cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg09184832 chr6:79620586 NA -0.5 -11.04 -0.4 4.73e-26 Intelligence (multi-trait analysis); BRCA cis rs1451375 1.000 rs10247443 chr7:50620586 G/A cg18232548 chr7:50535776 DDC 0.44 10.21 0.37 8.96e-23 Malaria; BRCA cis rs7246657 0.943 rs7255996 chr19:37971699 G/A cg14683738 chr19:37701593 ZNF585B 0.45 8.03 0.3 4.85e-15 Coronary artery calcification; BRCA cis rs244731 1.000 rs244731 chr5:176539679 C/T cg06060754 chr5:176797920 RGS14 0.67 10.47 0.38 9.09e-24 Urate levels in lean individuals; BRCA cis rs7927771 0.832 rs4752993 chr11:47410951 T/C cg18512352 chr11:47633146 NA 0.32 7.91 0.3 1.13e-14 Subjective well-being; BRCA cis rs13108904 0.967 rs12502916 chr4:1276349 G/A cg00684032 chr4:1343700 KIAA1530 -0.34 -8.83 -0.33 1.03e-17 Obesity-related traits; BRCA cis rs736408 0.511 rs12637632 chr3:52708073 A/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.47 10.04 0.37 3.92e-22 Bipolar disorder; BRCA cis rs4727027 0.870 rs1105261 chr7:148794442 T/G cg23583168 chr7:148888333 NA -0.76 -17.35 -0.57 1.58e-55 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs17376456 0.825 rs28705226 chr5:93233135 T/C cg25358565 chr5:93447407 FAM172A 1.17 18.51 0.59 1.52e-61 Diabetic retinopathy; BRCA cis rs78456975 1.000 rs10189336 chr2:1558015 G/A cg26248373 chr2:1572462 NA -0.49 -9.59 -0.35 1.96e-20 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs208515 0.525 rs12204706 chr6:66669930 A/G cg07460842 chr6:66804631 NA -0.84 -15.05 -0.51 5.01e-44 Exhaled nitric oxide levels; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg09263875 chr16:632152 PIGQ 0.73 21.27 0.64 2.61e-76 Height; BRCA cis rs35306767 0.714 rs67205460 chr10:1090366 C/T cg18964960 chr10:1102726 WDR37 0.66 9.21 0.34 4.67e-19 Eosinophil percentage of granulocytes; BRCA cis rs17685 0.632 rs1859793 chr7:75821283 G/A cg16489192 chr7:75678113 MDH2;STYXL1 -0.35 -7.94 -0.3 9.03e-15 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs1691799 0.867 rs1168333 chr12:66761377 G/A cg16791601 chr12:66731901 HELB -0.59 -15.64 -0.53 6.15e-47 White blood cell count (basophil); BRCA cis rs7520050 0.966 rs785520 chr1:46568836 T/C cg24296786 chr1:45957014 TESK2 0.41 9.14 0.34 8.37e-19 Red blood cell count;Reticulocyte count; BRCA cis rs2836974 0.644 rs2410123 chr21:40700093 C/T cg06238570 chr21:40685208 BRWD1 -0.45 -8.98 -0.33 3.03e-18 Cognitive function; BRCA cis rs9381040 0.610 rs6941090 chr6:41043465 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.44 -9.54 -0.35 3.04e-20 Alzheimer's disease (late onset); BRCA cis rs7607369 0.536 rs11892469 chr2:219669488 A/T cg02176678 chr2:219576539 TTLL4 -0.38 -10.14 -0.37 1.65e-22 Red blood cell count;Amyotrophic lateral sclerosis; BRCA trans rs7647973 0.710 rs9869120 chr3:49624065 T/C cg21659725 chr3:3221576 CRBN -0.49 -8.5 -0.32 1.31e-16 Menarche (age at onset); BRCA cis rs13118159 0.934 rs4974553 chr4:1356911 G/A cg20887711 chr4:1340912 KIAA1530 0.41 9.97 0.37 7.71e-22 Longevity; BRCA trans rs1829883 0.841 rs2948730 chr5:98723663 G/A cg08333243 chr5:99726346 NA 0.34 8.46 0.32 1.77e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs6570726 0.791 rs436498 chr6:145876347 G/A cg05347473 chr6:146136440 FBXO30 0.43 8.58 0.32 7.42e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs9649213 0.574 rs62478236 chr7:98030377 G/A cg01877450 chr7:97915802 BRI3 -0.39 -8.6 -0.32 6e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs12477438 0.501 rs9941561 chr2:99753829 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.86 26.68 0.73 5.88e-106 Chronic sinus infection; BRCA cis rs6964587 1.000 rs11971885 chr7:91674807 T/C cg17063962 chr7:91808500 NA 0.52 12.12 0.43 1.37e-30 Breast cancer; BRCA cis rs7772486 0.875 rs854148 chr6:146310979 G/C cg13319975 chr6:146136371 FBXO30 -0.38 -8.58 -0.32 7.02e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs4919694 1.000 rs7100592 chr10:104769098 T/G cg04362960 chr10:104952993 NT5C2 0.94 14.64 0.5 4.47e-42 Arsenic metabolism; BRCA trans rs11098499 0.954 rs11734241 chr4:120416872 A/G cg25214090 chr10:38739885 LOC399744 0.53 11.98 0.43 5.63e-30 Corneal astigmatism; BRCA cis rs10751667 0.621 rs7394681 chr11:952111 C/T cg01483505 chr11:975446 AP2A2 0.33 9.0 0.34 2.53e-18 Alzheimer's disease (late onset); BRCA cis rs6952808 0.689 rs12670737 chr7:2046830 C/T cg14004847 chr7:1930337 MAD1L1 -0.39 -8.2 -0.31 1.34e-15 Bipolar disorder and schizophrenia; BRCA cis rs9649213 0.593 rs7776638 chr7:97993506 C/T cg01877450 chr7:97915802 BRI3 -0.38 -8.62 -0.32 5.33e-17 Prostate cancer (SNP x SNP interaction); BRCA cis rs2019137 0.901 rs4849176 chr2:113977936 C/T cg21610815 chr2:113994035 PAX8;LOC654433;LOC440839 -0.61 -12.82 -0.45 1.23e-33 Lymphocyte counts; BRCA cis rs4074536 0.536 rs6670402 chr1:116289786 G/C cg21648376 chr1:116311395 CASQ2 -0.49 -8.71 -0.33 2.5e-17 QRS duration; BRCA cis rs6951245 0.744 rs10265758 chr7:1172518 C/T cg21664854 chr7:1097933 C7orf50;GPR146 0.49 9.92 0.37 1.11e-21 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs10479542 0.784 rs6601050 chr5:178986261 C/G cg19626725 chr5:178986131 RUFY1 -0.36 -11.19 -0.4 1.11e-26 Lung cancer; BRCA cis rs4148883 0.603 rs1893883 chr4:100124716 C/G cg12011299 chr4:100065546 ADH4 0.33 8.83 0.33 9.94e-18 Alcohol dependence; BRCA cis rs7772486 0.790 rs6926657 chr6:146255794 G/A cg23711669 chr6:146136114 FBXO30 -0.76 -17.5 -0.57 2.51e-56 Lobe attachment (rater-scored or self-reported); BRCA cis rs698833 0.886 rs4953091 chr2:44565266 A/C cg18685995 chr2:44588913 PREPL;C2orf34 -0.53 -10.83 -0.39 3.35e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs243505 0.559 rs10215794 chr7:148478895 C/G cg09806900 chr7:148480153 CUL1 0.56 11.19 0.4 1.19e-26 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3768617 0.591 rs9787073 chr1:182974328 T/C ch.1.3577855R chr1:183094577 LAMC1 0.51 11.84 0.42 2.15e-29 Fuchs's corneal dystrophy; BRCA cis rs3858526 0.514 rs4595572 chr11:5864045 T/G cg13902645 chr11:5959945 NA -0.51 -11.97 -0.43 6.39e-30 DNA methylation (variation); BRCA cis rs16857609 0.600 rs10932715 chr2:218259783 A/G cg15335768 chr2:218268053 DIRC3 -0.42 -9.71 -0.36 7.21e-21 Breast cancer;Breast cancer (estrogen-receptor negative); BRCA cis rs2153535 0.580 rs7767756 chr6:8453428 A/C cg21535247 chr6:8435926 SLC35B3 0.4 8.94 0.33 4.14e-18 Motion sickness; BRCA cis rs3125734 0.633 rs4979774 chr10:63967795 A/T cg19640130 chr10:64028056 RTKN2 -0.3 -8.66 -0.32 3.86e-17 Rheumatoid arthritis; BRCA cis rs10911232 0.524 rs10737238 chr1:183025303 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.58 0.55 1.28e-51 Hypertriglyceridemia; BRCA cis rs7772486 0.754 rs9386132 chr6:146140751 T/C cg05347473 chr6:146136440 FBXO30 0.46 9.0 0.34 2.59e-18 Lobe attachment (rater-scored or self-reported); BRCA cis rs35306767 0.903 rs34270014 chr10:904666 T/C cg20503657 chr10:835505 NA 1.0 17.49 0.57 2.89e-56 Eosinophil percentage of granulocytes; BRCA trans rs75804782 0.630 rs55708222 chr2:239287693 C/T cg01134436 chr17:81009848 B3GNTL1 0.74 7.95 0.3 8.66e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs6430585 0.527 rs12465544 chr2:136451676 C/T cg07169764 chr2:136633963 MCM6 1.0 19.33 0.61 6.52e-66 Corneal structure; BRCA cis rs826838 1.000 rs1843881 chr12:38733706 A/G cg26384229 chr12:38710491 ALG10B -0.86 -23.31 -0.68 1.96e-87 Heart rate; BRCA cis rs7267979 1.000 rs2257988 chr20:25270003 T/C cg08601574 chr20:25228251 PYGB 0.35 8.39 0.31 3.21e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs9807989 0.507 rs2041739 chr2:102994333 A/G cg03938978 chr2:103052716 IL18RAP -0.29 -8.34 -0.31 4.4e-16 Asthma; BRCA cis rs4478137 0.931 rs4057797 chr4:164245053 T/A cg06758707 chr4:164254230 NPY1R 0.56 12.25 0.44 3.81e-31 Subjective well-being (multi-trait analysis);Subjective well-being; BRCA cis rs7833790 1.000 rs1463259 chr8:82737745 A/G cg02079420 chr8:82753780 SNX16 0.34 7.94 0.3 9.33e-15 Diastolic blood pressure; BRCA trans rs6582630 0.519 rs4294627 chr12:38293982 C/T cg06521331 chr12:34319734 NA -0.47 -8.69 -0.33 2.99e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs10504229 0.728 rs55812114 chr8:58157453 C/T cg08219700 chr8:58056026 NA 0.54 9.01 0.34 2.27e-18 Developmental language disorder (linguistic errors); BRCA cis rs3771570 1.000 rs62186422 chr2:242249499 A/G cg21155796 chr2:242212141 HDLBP 0.61 9.63 0.36 1.42e-20 Prostate cancer; BRCA cis rs9487051 0.872 rs9487042 chr6:109610443 T/G cg01475377 chr6:109611718 NA -0.59 -16.46 -0.55 5.05e-51 Reticulocyte fraction of red cells; BRCA trans rs7824557 0.606 rs2736264 chr8:11186639 G/C cg06636001 chr8:8085503 FLJ10661 0.49 10.58 0.39 3.27e-24 Retinal vascular caliber; BRCA cis rs4434138 0.664 rs62255364 chr3:52701502 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.46 9.79 0.36 3.52e-21 Intelligence (multi-trait analysis); BRCA cis rs1577917 0.958 rs12213431 chr6:86500956 A/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.43 -11.72 -0.42 7.26e-29 Response to antipsychotic treatment; BRCA cis rs12586317 0.547 rs76770287 chr14:35487210 C/A cg05294307 chr14:35346193 BAZ1A -0.59 -10.21 -0.37 9.22e-23 Psoriasis; BRCA cis rs10870270 0.912 rs7079991 chr10:133736130 A/G cg26149184 chr10:133730230 NA 0.4 8.2 0.31 1.37e-15 Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals; BRCA cis rs7246657 0.722 rs954504 chr19:38045394 A/G cg23950597 chr19:37808831 NA -0.5 -8.62 -0.32 5.36e-17 Coronary artery calcification; BRCA cis rs796364 0.806 rs76112266 chr2:201087157 C/G cg12253985 chr2:200820533 C2orf60;C2orf47 -0.56 -8.01 -0.3 5.62e-15 Schizophrenia; BRCA cis rs1829883 0.626 rs2548089 chr5:98910440 A/C cg08333243 chr5:99726346 NA 0.36 8.49 0.32 1.49e-16 Hemostatic factors and hematological phenotypes; BRCA cis rs7178424 1.000 rs11071649 chr15:62312297 A/G cg00456672 chr15:62358751 C2CD4A -0.38 -8.69 -0.33 3.04e-17 Height; BRCA cis rs8177253 0.511 rs9830001 chr3:133433470 A/G cg01448562 chr3:133502909 NA 0.37 8.42 0.32 2.4e-16 Iron status biomarkers; BRCA cis rs4148883 0.645 rs2851264 chr4:100029715 C/T cg13256891 chr4:100009986 ADH5 0.38 8.07 0.3 3.39e-15 Alcohol dependence; BRCA cis rs12540874 0.529 rs732215 chr7:50544063 A/C cg18232548 chr7:50535776 DDC -0.53 -13.52 -0.47 8.44e-37 Systemic sclerosis; BRCA cis rs9443645 0.810 rs9448610 chr6:79739622 G/A cg18132916 chr6:79620363 NA -0.46 -10.31 -0.38 3.58e-23 Intelligence (multi-trait analysis); BRCA cis rs6570726 0.791 rs2096201 chr6:145934273 C/T cg23711669 chr6:146136114 FBXO30 0.78 18.48 0.59 2.19e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs7312933 0.670 rs10880269 chr12:42606135 C/T cg01256987 chr12:42539512 GXYLT1 -0.46 -9.21 -0.34 4.74e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2204008 0.837 rs11611861 chr12:38357459 A/G cg26384229 chr12:38710491 ALG10B 0.74 17.32 0.57 2.11e-55 Bladder cancer; BRCA cis rs7615952 0.599 rs6779141 chr3:125709995 A/T cg15145296 chr3:125709740 NA -0.56 -8.93 -0.33 4.5e-18 Blood pressure (smoking interaction); BRCA cis rs4363385 0.747 rs1999886 chr1:152955522 T/C cg25856811 chr1:152973957 SPRR3 -0.33 -8.79 -0.33 1.42e-17 Inflammatory skin disease; BRCA cis rs4478858 0.698 rs10914370 chr1:31854955 T/C cg00250761 chr1:31883323 NA -0.32 -8.42 -0.32 2.56e-16 Alcohol dependence; BRCA cis rs3820928 1.000 rs4675120 chr2:227774888 C/T cg11843606 chr2:227700838 RHBDD1 -0.38 -8.46 -0.32 1.8e-16 Pulmonary function; BRCA cis rs12048904 0.533 rs1590580 chr1:101292668 A/G cg16556008 chr1:101360663 SLC30A7;EXTL2 0.69 16.92 0.56 2.43e-53 Multiple sclerosis; BRCA cis rs6977660 1.000 rs10260360 chr7:19792824 T/C cg05791153 chr7:19748676 TWISTNB 0.43 8.48 0.32 1.51e-16 Thyroid stimulating hormone; BRCA cis rs4853036 0.903 rs13021969 chr2:70117602 T/C cg02498382 chr2:70120550 SNRNP27 -0.54 -10.67 -0.39 1.49e-24 Colorectal or endometrial cancer; BRCA cis rs2204008 0.837 rs7974888 chr12:37945215 A/G cg26384229 chr12:38710491 ALG10B 0.67 15.23 0.52 6.4e-45 Bladder cancer; BRCA cis rs1129187 0.935 rs4987173 chr6:42931224 G/A cg10862848 chr6:42927986 GNMT -0.36 -15.05 -0.51 5.13e-44 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs9733 0.744 rs12758227 chr1:150844583 C/A cg13175981 chr1:150552382 MCL1 0.41 9.04 0.34 1.79e-18 Tonsillectomy; BRCA cis rs7618501 0.633 rs12496973 chr3:50002245 T/C cg24110177 chr3:50126178 RBM5 -0.39 -10.7 -0.39 1.08e-24 Intelligence (multi-trait analysis); BRCA cis rs4728302 0.559 rs7779409 chr7:133158475 A/G cg10665199 chr7:133106180 EXOC4 0.47 10.1 0.37 2.29e-22 Intelligence;Intelligence (multi-trait analysis); BRCA cis rs4363385 0.667 rs73014331 chr1:152964533 A/G cg21543102 chr1:152974771 SPRR3 -0.3 -8.32 -0.31 5.29e-16 Inflammatory skin disease; BRCA cis rs637571 0.522 rs566590 chr11:65754062 C/T cg17985854 chr11:65770987 BANF1;EIF1AD 0.41 10.12 0.37 1.94e-22 Eosinophil percentage of white cells; BRCA cis rs35306767 0.622 rs66462130 chr10:1022108 C/T cg20503657 chr10:835505 NA 1.04 15.8 0.53 9.87e-48 Eosinophil percentage of granulocytes; BRCA cis rs711245 0.573 rs7570763 chr2:36800589 A/C cg09467607 chr2:36825704 FEZ2 -0.62 -15.26 -0.52 4.57e-45 Height; BRCA cis rs12368653 0.641 rs12826708 chr12:58058373 G/A cg18357645 chr12:58087776 OS9 0.36 10.08 0.37 2.81e-22 Multiple sclerosis; BRCA cis rs4076764 0.958 rs11580702 chr1:163385523 C/G cg06092702 chr1:163392909 NA -0.36 -9.66 -0.36 1.06e-20 Motion sickness; BRCA cis rs10193935 0.792 rs2053349 chr2:42516205 G/A cg27598129 chr2:42591480 NA -0.66 -11.14 -0.4 1.88e-26 Colonoscopy-negative controls vs population controls; BRCA trans rs6479891 0.915 rs7091664 chr10:65101800 G/A cg14819942 chr15:35414228 NA -0.34 -8.48 -0.32 1.54e-16 Arthritis (juvenile idiopathic); BRCA cis rs6964587 0.967 rs34344935 chr7:91835436 G/A cg01689657 chr7:91764605 CYP51A1 0.25 8.61 0.32 5.78e-17 Breast cancer; BRCA cis rs6815814 0.950 rs113465719 chr4:38808045 A/T cg02016764 chr4:38805732 TLR1 -0.6 -9.49 -0.35 4.33e-20 Breast cancer; BRCA cis rs9457247 1.000 rs400063 chr6:167386592 C/T cg00271210 chr6:167070053 RPS6KA2 -0.32 -8.55 -0.32 8.91e-17 Crohn's disease; BRCA cis rs1552244 0.882 rs2130813 chr3:10038706 A/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.89 17.27 0.56 3.83e-55 Alzheimer's disease; BRCA cis rs2204008 0.774 rs10400552 chr12:38393577 C/G cg13010199 chr12:38710504 ALG10B 0.48 9.91 0.37 1.23e-21 Bladder cancer; BRCA cis rs13108904 0.557 rs1680033 chr4:1243404 C/T cg02475777 chr4:1388615 CRIPAK -0.52 -10.15 -0.37 1.56e-22 Obesity-related traits; BRCA cis rs61931739 0.500 rs11052990 chr12:34058647 T/A cg06521331 chr12:34319734 NA -0.62 -11.17 -0.4 1.44e-26 Morning vs. evening chronotype; BRCA trans rs7939886 0.920 rs1482009 chr11:55884690 T/G cg15704280 chr7:45808275 SEPT13 0.62 7.96 0.3 7.6e-15 Myopia (pathological); BRCA cis rs4975709 0.569 rs2077269 chr5:1863506 C/T cg15595755 chr5:1867978 NA 0.33 7.96 0.3 8.02e-15 Cardiovascular disease risk factors; BRCA cis rs10256972 0.732 rs12701856 chr7:1107707 C/T cg03188948 chr7:1209495 NA 0.5 9.28 0.34 2.5e-19 Longevity;Endometriosis; BRCA cis rs9790314 0.967 rs339101 chr3:161064193 A/T cg04691961 chr3:161091175 C3orf57 -0.62 -15.07 -0.51 3.8e-44 Morning vs. evening chronotype; BRCA trans rs1994135 0.654 rs11052759 chr12:33724126 G/A cg26384229 chr12:38710491 ALG10B 0.6 12.16 0.43 9.04e-31 Resting heart rate; BRCA cis rs35306767 0.903 rs12762228 chr10:880854 G/A cg20503657 chr10:835505 NA 1.3 21.72 0.65 9.26e-79 Eosinophil percentage of granulocytes; BRCA cis rs897984 0.542 rs35713203 chr16:31090407 G/C cg00531865 chr16:30841666 NA -0.38 -8.76 -0.33 1.76e-17 Dementia with Lewy bodies; BRCA cis rs3106136 0.546 rs2632417 chr4:95137542 G/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.08 -0.37 2.82e-22 Capecitabine sensitivity; BRCA cis rs2637266 1.000 rs2395390 chr10:78357734 C/G cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.23e-14 Pulmonary function; BRCA cis rs7727544 0.735 rs2631370 chr5:131703776 T/C cg24060327 chr5:131705240 SLC22A5 0.48 10.06 0.37 3.27e-22 Blood metabolite levels; BRCA cis rs10504229 0.679 rs16920056 chr8:58106218 C/A cg20607798 chr8:58055168 NA 0.47 8.07 0.3 3.41e-15 Developmental language disorder (linguistic errors); BRCA cis rs7582180 0.676 rs11691135 chr2:100934038 C/T cg14675211 chr2:100938903 LONRF2 0.52 12.07 0.43 2.29e-30 Intelligence (multi-trait analysis); BRCA cis rs7659604 0.702 rs6826506 chr4:122710865 T/G cg20573242 chr4:122745356 CCNA2 0.45 9.89 0.36 1.49e-21 Type 2 diabetes; BRCA cis rs2239547 0.563 rs4302374 chr3:52905802 T/C cg11645453 chr3:52864694 ITIH4 0.47 10.73 0.39 8.52e-25 Schizophrenia; BRCA cis rs7647973 0.710 rs34890793 chr3:49619493 C/T cg07636037 chr3:49044803 WDR6 0.58 9.29 0.35 2.3e-19 Menarche (age at onset); BRCA cis rs312274 0.588 rs11179030 chr12:41309245 G/A cg17827154 chr12:41323612 CNTN1 -0.45 -11.21 -0.41 9.82e-27 Metabolite levels (X-11787); BRCA cis rs17666538 0.585 rs1703927 chr8:613620 A/G cg07234876 chr8:600039 NA -0.75 -9.28 -0.34 2.69e-19 IgG glycosylation; BRCA cis rs495337 0.760 rs4810994 chr20:48571673 C/T cg17835207 chr20:48524531 SPATA2 -0.67 -16.84 -0.55 6.21e-53 Psoriasis; BRCA cis rs7520050 0.966 rs10890352 chr1:46283628 G/A cg24296786 chr1:45957014 TESK2 0.44 9.85 0.36 2.07e-21 Red blood cell count;Reticulocyte count; BRCA cis rs9300255 0.566 rs1716169 chr12:123716930 A/T cg00376283 chr12:123451042 ABCB9 0.51 10.1 0.37 2.36e-22 Neutrophil percentage of white cells; BRCA cis rs6121246 0.559 rs6060933 chr20:30351903 C/T cg13852791 chr20:30311386 BCL2L1 0.96 23.37 0.68 8.7e-88 Mean corpuscular hemoglobin; BRCA cis rs4363385 0.720 rs6665527 chr1:152967009 C/A cg25856811 chr1:152973957 SPRR3 -0.36 -9.43 -0.35 7.23e-20 Inflammatory skin disease; BRCA cis rs2191566 1.000 rs10418363 chr19:44525463 A/G cg20607764 chr19:44506953 ZNF230 -0.42 -9.37 -0.35 1.27e-19 Acute lymphoblastic leukemia (childhood); BRCA cis rs17376456 0.825 rs28534784 chr5:93063332 C/A cg21475434 chr5:93447410 FAM172A 0.61 8.19 0.31 1.43e-15 Diabetic retinopathy; BRCA cis rs7178424 0.875 rs17271193 chr15:62165168 A/G cg00456672 chr15:62358751 C2CD4A -0.39 -8.82 -0.33 1.12e-17 Height; BRCA cis rs1059312 0.808 rs4760537 chr12:129301299 C/A cg23521905 chr12:129298690 SLC15A4;MGC16384 0.32 10.89 0.4 1.96e-25 Systemic lupus erythematosus; BRCA cis rs9291683 0.530 rs73227883 chr4:9979279 T/C cg11266682 chr4:10021025 SLC2A9 0.4 10.53 0.38 5.26e-24 Bone mineral density; BRCA cis rs2760061 0.598 rs1774755 chr1:228115282 T/G cg02753203 chr1:228287806 NA -0.57 -11.93 -0.43 9.2e-30 Diastolic blood pressure; BRCA trans rs2727020 0.521 rs7107178 chr11:49526668 G/A cg11707556 chr5:10655725 ANKRD33B 0.42 9.39 0.35 1.06e-19 Coronary artery disease; BRCA cis rs858239 0.632 rs1985769 chr7:23122506 T/G cg23682824 chr7:23144976 KLHL7 0.45 11.83 0.42 2.53e-29 Cerebrospinal fluid biomarker levels; BRCA cis rs1371614 0.632 rs6547318 chr2:27153481 A/C cg00617064 chr2:27272375 NA -0.31 -7.9 -0.3 1.26e-14 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs611744 0.529 rs13282825 chr8:109263237 T/C cg21045802 chr8:109455806 TTC35 0.34 7.87 0.3 1.52e-14 Dupuytren's disease; BRCA cis rs7903847 0.642 rs11189200 chr10:99156273 C/G cg08345082 chr10:99160200 RRP12 -0.3 -8.72 -0.33 2.41e-17 Granulocyte percentage of myeloid white cells; BRCA trans rs2840044 1.000 rs11656138 chr17:33910218 T/C cg19694781 chr19:47549865 TMEM160 0.45 10.47 0.38 8.73e-24 Response to radiotherapy in cancer (late toxicity); BRCA cis rs5758659 0.682 rs133306 chr22:42396150 G/A cg15557168 chr22:42548783 NA -0.32 -8.81 -0.33 1.16e-17 Cognitive function; BRCA cis rs477895 0.653 rs7102327 chr11:63908720 C/T cg23719950 chr11:63933701 MACROD1 -0.58 -9.87 -0.36 1.79e-21 Mean platelet volume; BRCA trans rs11098499 0.863 rs1480936 chr4:120462861 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.38 8.57 0.32 8e-17 Corneal astigmatism; BRCA trans rs7613875 0.537 rs6446195 chr3:50070853 A/G cg21659725 chr3:3221576 CRBN -0.33 -7.86 -0.3 1.66e-14 Body mass index; BRCA cis rs10782582 0.593 rs12132750 chr1:76136222 A/G cg03433033 chr1:76189801 ACADM -0.46 -9.58 -0.35 2.1e-20 Daytime sleep phenotypes; BRCA cis rs6912958 1.000 rs13214153 chr6:88153983 G/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -9.0 -0.34 2.53e-18 Monocyte percentage of white cells; BRCA cis rs11997175 0.624 rs4621768 chr8:33677452 T/C ch.8.33884649F chr8:33765107 NA 0.4 9.19 0.34 5.56e-19 Body mass index; BRCA cis rs6089829 0.855 rs6090205 chr20:61665269 A/G cg03213289 chr20:61660250 NA 0.61 16.28 0.54 4.14e-50 Prostate cancer (SNP x SNP interaction); BRCA cis rs3784262 0.528 rs17820966 chr15:58336662 A/G cg12031962 chr15:58353849 ALDH1A2 0.37 9.93 0.37 1.06e-21 Barrett's esophagus;Digestive system disease (Barrett's esophagus and esophageal adenocarcinoma combined); BRCA trans rs801193 1.000 rs4717319 chr7:66242593 A/G cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.27 0.31 7.89e-16 Aortic root size; BRCA cis rs1129187 0.755 rs3818554 chr6:42934620 C/T cg09436375 chr6:42928200 GNMT -0.29 -10.79 -0.39 4.82e-25 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs78707713 0.511 rs28697194 chr10:71215483 T/C cg12610070 chr10:71211762 TSPAN15 -0.33 -11.49 -0.41 6.43e-28 Venous thromboembolism; BRCA trans rs1200821 0.641 rs11011162 chr10:37674483 G/C cg25427524 chr10:38739819 LOC399744 0.38 8.16 0.31 1.83e-15 Hemostatic factors and hematological phenotypes; BRCA cis rs2303759 0.830 rs7257053 chr19:49894456 C/G cg22307029 chr19:49891270 CCDC155 0.65 11.42 0.41 1.3e-27 Multiple sclerosis; BRCA cis rs736408 0.609 rs13095332 chr3:52787242 C/T cg18404041 chr3:52824283 ITIH1 -0.43 -12.7 -0.45 4.14e-33 Bipolar disorder; BRCA cis rs7819412 0.502 rs4841499 chr8:10988138 A/C cg21775007 chr8:11205619 TDH -0.51 -9.49 -0.35 4.46e-20 Triglycerides; BRCA cis rs6570726 0.791 rs443628 chr6:145883484 T/C cg23711669 chr6:146136114 FBXO30 0.77 18.52 0.59 1.33e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs11622475 1.000 rs12889168 chr14:104481957 A/T cg12183467 chr14:104352244 NA -0.46 -9.52 -0.35 3.5e-20 Bipolar disorder; BRCA cis rs7662987 0.517 rs1311618 chr4:100012612 A/G cg13256891 chr4:100009986 ADH5 0.54 10.14 0.37 1.65e-22 Smoking initiation; BRCA cis rs243505 0.964 rs243517 chr7:148425915 T/A cg09806900 chr7:148480153 CUL1 -0.4 -8.35 -0.31 4.36e-16 Inflammatory bowel disease;Crohn's disease; BRCA cis rs3091242 0.934 rs686631 chr1:25719599 A/T cg27572855 chr1:25598939 RHD 0.47 13.11 0.46 6.08e-35 Erythrocyte sedimentation rate; BRCA cis rs7267979 1.000 rs2257496 chr20:25279315 A/G cg08601574 chr20:25228251 PYGB 0.35 8.49 0.32 1.48e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs896543 0.657 rs10179774 chr2:237487588 C/T cg25295825 chr2:237489920 CXCR7 0.49 9.75 0.36 5.06e-21 Alcohol dependence (age at onset); BRCA cis rs8031584 0.560 rs1056118 chr15:31203786 G/A cg14829155 chr15:31115871 NA 0.42 10.04 0.37 4.07e-22 Huntington's disease progression; BRCA cis rs8038465 0.622 rs17185294 chr15:73858415 C/T cg15420318 chr15:73925796 NPTN -0.44 -9.76 -0.36 4.67e-21 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs12618769 0.597 rs3769723 chr2:99105988 A/G cg10123293 chr2:99228465 UNC50 0.42 8.43 0.32 2.38e-16 Bipolar disorder; BRCA cis rs7666738 0.800 rs13106995 chr4:99028790 A/T cg05340658 chr4:99064831 C4orf37 0.69 17.46 0.57 4.29e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.552 rs2949195 chr7:1202705 G/A cg15112475 chr7:1198522 ZFAND2A -0.58 -14.19 -0.49 6.18e-40 Longevity;Endometriosis; BRCA cis rs10504229 0.773 rs1874373 chr8:58194423 T/C cg22535103 chr8:58192502 C8orf71 -0.6 -13.12 -0.46 5.64e-35 Developmental language disorder (linguistic errors); BRCA cis rs9660992 0.710 rs1668872 chr1:205236069 G/A cg00857998 chr1:205179979 DSTYK 0.45 8.42 0.32 2.42e-16 Mean corpuscular volume;Mean platelet volume; BRCA cis rs3741404 0.609 rs641430 chr11:63869531 C/T cg18225595 chr11:63971243 STIP1 -0.4 -9.96 -0.37 7.91e-22 Platelet count; BRCA cis rs1832871 0.619 rs827861 chr6:158710074 C/A cg07215822 chr6:158701037 NA -0.51 -10.56 -0.39 3.93e-24 Height; BRCA cis rs67460515 0.892 rs11711695 chr3:161057593 A/G cg03342759 chr3:160939853 NMD3 -0.77 -18.35 -0.59 9.86e-61 Parkinson's disease; BRCA cis rs17376456 1.000 rs12187701 chr5:93522290 A/G cg21475434 chr5:93447410 FAM172A 0.73 9.13 0.34 8.89e-19 Diabetic retinopathy; BRCA cis rs1215050 0.791 rs2658477 chr4:98850993 G/A cg05340658 chr4:99064831 C4orf37 -0.44 -10.13 -0.37 1.89e-22 Waist-to-hip ratio adjusted for body mass index; BRCA trans rs75804782 0.641 rs56000747 chr2:239318541 T/G cg01134436 chr17:81009848 B3GNTL1 0.78 9.84 0.36 2.34e-21 Morning vs. evening chronotype;Chronotype; BRCA cis rs1534166 0.647 rs13321680 chr3:133507119 G/T cg27366882 chr3:133540807 NA -0.33 -7.99 -0.3 6.23e-15 Alcohol consumption (transferrin glycosylation); BRCA trans rs8073060 0.586 rs226084 chr17:34019582 T/A cg19694781 chr19:47549865 TMEM160 -1.07 -21.69 -0.65 1.28e-78 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs2153535 0.580 rs1034273 chr6:8468145 A/G cg23788917 chr6:8435910 SLC35B3 0.48 10.41 0.38 1.48e-23 Motion sickness; BRCA cis rs2404602 0.647 rs2404604 chr15:76991105 A/G cg23625390 chr15:77176239 SCAPER -0.55 -13.14 -0.46 4.54e-35 Blood metabolite levels; BRCA trans rs61931739 0.534 rs4086956 chr12:34105047 A/T cg26384229 chr12:38710491 ALG10B 0.57 12.26 0.44 3.38e-31 Morning vs. evening chronotype; BRCA cis rs13108904 0.901 rs1680073 chr4:1280337 G/A cg05665937 chr4:1216051 CTBP1 -0.39 -8.4 -0.32 2.92e-16 Obesity-related traits; BRCA cis rs11190604 1.000 rs7070776 chr10:102264672 A/G cg07080220 chr10:102295463 HIF1AN 0.59 14.28 0.49 2.31e-40 Palmitoleic acid (16:1n-7) levels; BRCA cis rs10504229 0.683 rs55645894 chr8:58116145 A/G cg22535103 chr8:58192502 C8orf71 -0.45 -9.05 -0.34 1.65e-18 Developmental language disorder (linguistic errors); BRCA cis rs7523050 0.643 rs35050241 chr1:109404876 T/C cg08274380 chr1:109419600 GPSM2 0.98 14.02 0.49 3.82e-39 Fat distribution (HIV); BRCA cis rs56399783 0.614 rs11772508 chr7:2771504 A/C cg19731401 chr7:2775893 GNA12 -0.5 -8.14 -0.31 2.1e-15 Childhood ear infection; BRCA cis rs936229 0.954 rs936230 chr15:75145098 C/T cg10253484 chr15:75165896 SCAMP2 0.51 9.76 0.36 4.66e-21 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs2073300 0.609 rs2281434 chr20:23378101 C/A cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.43e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs2576037 0.583 rs1465722 chr18:44564499 C/G cg07416455 chr18:44543612 TCEB3CL;KATNAL2 0.55 11.35 0.41 2.45e-27 Personality dimensions; BRCA cis rs2797685 0.755 rs41402249 chr1:7822723 C/G cg04725166 chr1:7887271 PER3 0.48 8.85 0.33 8.3e-18 Crohn's disease; BRCA cis rs7666738 0.830 rs4492007 chr4:98959848 A/T cg17366294 chr4:99064904 C4orf37 0.44 10.49 0.38 7.52e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg19847866 chr10:1019161 NA -0.51 -10.27 -0.38 5.12e-23 Response to angiotensin II receptor blocker therapy; BRCA cis rs56399783 0.901 rs73051444 chr7:2866529 G/A cg19731401 chr7:2775893 GNA12 0.51 8.4 0.32 2.97e-16 Childhood ear infection; BRCA cis rs6545883 0.560 rs11677776 chr2:61503113 T/C cg15711740 chr2:61764176 XPO1 0.33 8.17 0.31 1.65e-15 Tuberculosis; BRCA cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg11822812 chr5:140052017 DND1 0.31 8.4 0.32 2.86e-16 Depressive symptoms (multi-trait analysis); BRCA cis rs514406 0.929 rs557847 chr1:53333116 A/G cg24675658 chr1:53192096 ZYG11B -0.52 -11.18 -0.4 1.3e-26 Monocyte count; BRCA cis rs10504229 1.000 rs72650885 chr8:58175131 G/A cg05313129 chr8:58192883 C8orf71 -0.47 -9.73 -0.36 6.11e-21 Developmental language disorder (linguistic errors); BRCA cis rs28374715 0.681 rs28712264 chr15:41588797 T/C cg18705301 chr15:41695430 NDUFAF1 -1.03 -22.26 -0.66 1.07e-81 Ulcerative colitis; BRCA trans rs11098499 0.789 rs10212719 chr4:120254437 T/C cg25214090 chr10:38739885 LOC399744 0.46 10.6 0.39 2.61e-24 Corneal astigmatism; BRCA cis rs7772486 0.692 rs1577916 chr6:146069789 G/A cg05347473 chr6:146136440 FBXO30 -0.43 -8.76 -0.33 1.79e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs7917772 0.636 rs7088981 chr10:104520423 T/C cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -10.35 -0.38 2.58e-23 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs9859260 0.744 rs406271 chr3:195776976 T/C cg03462622 chr3:195777018 TFRC -0.38 -8.62 -0.32 5.42e-17 Mean corpuscular volume; BRCA cis rs4665809 0.838 rs7565843 chr2:26292912 G/C cg04944784 chr2:26401820 FAM59B -0.69 -11.47 -0.41 8.14e-28 Gut microbiome composition (summer); BRCA cis rs7811142 0.830 rs705866 chr7:99965285 T/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.55 8.26 0.31 8.57e-16 Platelet count; BRCA cis rs4665809 1.000 rs2384322 chr2:26291146 C/G cg25036284 chr2:26402008 FAM59B -0.8 -12.52 -0.44 2.6e-32 Gut microbiome composition (summer); BRCA cis rs7267979 0.966 rs416745 chr20:25438868 T/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs10504229 0.683 rs59679713 chr8:58134370 G/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.85 -0.33 8.45e-18 Developmental language disorder (linguistic errors); BRCA cis rs4363385 0.720 rs9325996 chr1:152965347 A/G cg25856811 chr1:152973957 SPRR3 -0.34 -9.36 -0.35 1.35e-19 Inflammatory skin disease; BRCA cis rs6089829 0.962 rs6062777 chr20:61663748 G/A cg08564027 chr20:61660810 NA 0.85 22.82 0.67 9.28e-85 Prostate cancer (SNP x SNP interaction); BRCA cis rs965469 0.846 rs7271575 chr20:3333877 C/T cg25506879 chr20:3388711 C20orf194 -0.53 -10.5 -0.38 6.58e-24 IFN-related cytopenia; BRCA cis rs7666738 0.753 rs28390295 chr4:99028497 C/A cg05340658 chr4:99064831 C4orf37 0.69 17.38 0.57 1.11e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs6060717 0.536 rs17431878 chr20:34502107 G/A cg04508476 chr20:34239394 CPNE1;RBM12 -0.59 -8.14 -0.31 2.02e-15 Hip circumference adjusted for BMI; BRCA cis rs7246657 0.722 rs2972458 chr19:38135403 T/C cg18154014 chr19:37997991 ZNF793 -0.49 -9.34 -0.35 1.59e-19 Coronary artery calcification; BRCA cis rs240110 0.539 rs6934256 chr6:101338728 G/A cg09795085 chr6:101329169 ASCC3 0.4 8.13 0.31 2.17e-15 Neuroticism; BRCA cis rs9790314 0.846 rs7652267 chr3:160998497 A/G cg04691961 chr3:161091175 C3orf57 -0.4 -9.88 -0.36 1.61e-21 Morning vs. evening chronotype; BRCA cis rs2842992 0.747 rs9365095 chr6:160192928 T/G cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.27 0.59 2.7e-60 Age-related macular degeneration (geographic atrophy); BRCA cis rs7666738 0.830 rs62321598 chr4:99014237 C/T cg17366294 chr4:99064904 C4orf37 0.46 10.87 0.39 2.33e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs10504229 1.000 rs17805326 chr8:58169533 A/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.48 -0.47 1.31e-36 Developmental language disorder (linguistic errors); BRCA cis rs4953076 0.573 rs7595470 chr2:44402467 A/G cg04920474 chr2:44395004 PPM1B 0.49 9.89 0.36 1.45e-21 Height; BRCA cis rs6964587 0.934 rs7793861 chr7:91742728 C/G cg17063962 chr7:91808500 NA 0.53 12.58 0.45 1.42e-32 Breast cancer; BRCA cis rs2019137 0.539 rs11123170 chr2:113978940 C/G cg21550016 chr2:113992930 PAX8;LOC440839;LOC654433 0.74 16.31 0.54 2.89e-50 Lymphocyte counts; BRCA cis rs2635047 1.000 rs2635049 chr18:44687303 C/T cg19077165 chr18:44547161 KATNAL2 0.39 8.3 0.31 6.39e-16 Educational attainment; BRCA cis rs6701037 0.681 rs34370567 chr1:175131340 C/T cg00321850 chr1:175162397 KIAA0040 -0.4 -11.26 -0.41 6.13e-27 Alcohol dependence; BRCA cis rs4595586 0.545 rs12820138 chr12:39357049 A/G cg26384229 chr12:38710491 ALG10B 0.42 9.34 0.35 1.54e-19 Morning vs. evening chronotype; BRCA cis rs4409675 0.576 rs6565 chr1:28213157 T/C cg23691781 chr1:28212827 C1orf38 0.33 11.27 0.41 5.37e-27 Corneal astigmatism; BRCA cis rs6952808 0.723 rs57216949 chr7:2030287 G/T cg04267008 chr7:1944627 MAD1L1 -0.6 -13.53 -0.47 7.4e-37 Bipolar disorder and schizophrenia; BRCA cis rs2075371 1.000 rs2598286 chr7:133976029 G/A cg11752832 chr7:134001865 SLC35B4 0.52 13.5 0.47 1.06e-36 Mean platelet volume; BRCA trans rs2204008 0.729 rs2892365 chr12:38446760 G/C cg06521331 chr12:34319734 NA 0.46 9.03 0.34 2.02e-18 Bladder cancer; BRCA cis rs10045504 0.502 rs17456198 chr5:38732005 A/G cg15396434 chr5:38725168 NA -0.55 -10.54 -0.38 4.81e-24 Night sleep phenotypes; BRCA cis rs782590 0.557 rs7592219 chr2:55887176 T/C cg18811423 chr2:55921094 PNPT1 -0.51 -12.5 -0.44 2.99e-32 Metabolic syndrome; BRCA cis rs514406 0.505 rs269289 chr1:53167151 A/C cg08859206 chr1:53392774 SCP2 -0.4 -8.67 -0.32 3.41e-17 Monocyte count; BRCA cis rs28830936 1.000 rs4924570 chr15:41974660 A/G cg17847044 chr15:42102381 MAPKBP1 -0.33 -9.17 -0.34 6.18e-19 Diastolic blood pressure; BRCA cis rs7927771 0.542 rs10769300 chr11:47865560 C/T cg20307385 chr11:47447363 PSMC3 0.42 9.49 0.35 4.65e-20 Subjective well-being; BRCA cis rs2836974 0.897 rs2836944 chr21:40593539 G/A cg17971929 chr21:40555470 PSMG1 0.79 18.52 0.59 1.31e-61 Cognitive function; BRCA cis rs6860806 0.507 rs272878 chr5:131671769 C/T cg11843238 chr5:131593191 PDLIM4 -0.34 -7.81 -0.3 2.34e-14 Breast cancer; BRCA cis rs6570726 0.764 rs1912023 chr6:145824278 C/A cg05347473 chr6:146136440 FBXO30 0.41 8.07 0.3 3.41e-15 Lobe attachment (rater-scored or self-reported); BRCA cis rs3749237 1.000 rs11130214 chr3:49735746 C/G cg03060546 chr3:49711283 APEH -0.46 -10.08 -0.37 2.89e-22 Resting heart rate; BRCA cis rs7918232 0.941 rs4749228 chr10:27433618 C/T cg14240646 chr10:27532245 ACBD5 0.64 9.43 0.35 7.69e-20 Breast cancer; BRCA cis rs2439831 0.702 rs7175032 chr15:44060236 C/T cg10011062 chr15:43941034 CATSPER2 -0.53 -7.87 -0.3 1.52e-14 Lung cancer in ever smokers; BRCA cis rs3806843 0.868 rs2262574 chr5:140123635 G/T cg16179182 chr5:140090404 VTRNA1-1 0.41 9.26 0.34 2.99e-19 Depressive symptoms (multi-trait analysis); BRCA cis rs72781680 0.678 rs872169 chr2:24259188 C/G cg06627628 chr2:24431161 ITSN2 -0.55 -8.91 -0.33 5.12e-18 Lymphocyte counts; BRCA trans rs9325144 0.647 rs3759139 chr12:39087609 G/A cg23762105 chr12:34175262 ALG10 0.35 7.95 0.3 8.49e-15 Morning vs. evening chronotype; BRCA cis rs12612619 0.579 rs6722906 chr2:27080035 C/A cg12368169 chr2:27073192 DPYSL5 -0.33 -10.05 -0.37 3.66e-22 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs17401966 1.000 rs3753037 chr1:10355834 C/T cg15208524 chr1:10270712 KIF1B 0.37 8.25 0.31 9e-16 Hepatocellular carcinoma; BRCA cis rs5758659 0.714 rs5758574 chr22:42481400 G/C cg15557168 chr22:42548783 NA 0.3 8.41 0.32 2.58e-16 Cognitive function; BRCA cis rs11252926 0.604 rs2050970 chr10:515870 C/T cg18196295 chr10:418757 DIP2C 0.38 8.83 0.33 9.96e-18 Psychosis in Alzheimer's disease; BRCA cis rs7811142 0.830 rs73401450 chr7:99981859 G/C cg01860168 chr7:100026446 MEPCE;ZCWPW1 0.56 8.99 0.34 2.76e-18 Platelet count; BRCA cis rs6912958 0.781 rs9444522 chr6:88309705 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.49 -0.32 1.48e-16 Monocyte percentage of white cells; BRCA cis rs6951245 0.832 rs10266519 chr7:1142977 C/T cg04025307 chr7:1156635 C7orf50 0.58 9.64 0.36 1.28e-20 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs1005277 0.579 rs1780116 chr10:38526621 C/T cg17830980 chr10:43048298 ZNF37B -0.55 -13.31 -0.47 7.8e-36 Extrinsic epigenetic age acceleration; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg15112475 chr7:1198522 ZFAND2A -0.45 -9.92 -0.37 1.12e-21 Longevity;Endometriosis; BRCA cis rs10791323 0.604 rs2723598 chr11:133711652 G/A cg14349672 chr11:133703707 NA -0.42 -9.2 -0.34 4.99e-19 Childhood ear infection; BRCA cis rs7666738 0.830 rs60391193 chr4:98933912 T/G cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.28e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.14 0.34 8.4e-19 Tonsillectomy; BRCA cis rs12431939 1.000 rs58225416 chr14:51662196 C/T cg23942311 chr14:51606299 NA -0.43 -8.04 -0.3 4.5e-15 Cancer; BRCA cis rs7666738 0.830 rs7664305 chr4:99037691 G/A cg05340658 chr4:99064831 C4orf37 0.69 17.45 0.57 4.94e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6088580 0.634 rs6059905 chr20:33126946 T/C cg24642439 chr20:33292090 TP53INP2 0.54 11.74 0.42 6.14e-29 Glomerular filtration rate (creatinine); BRCA cis rs600806 0.888 rs3879449 chr1:109904971 A/T cg20591472 chr1:110008990 SYPL2 0.32 8.12 0.31 2.4e-15 Intelligence (multi-trait analysis); BRCA cis rs586533 0.758 rs1690818 chr11:99496554 C/T cg22878054 chr11:99397252 CNTN5 0.32 7.85 0.3 1.8e-14 Depressive symptoms (multi-trait analysis); BRCA cis rs2836974 0.796 rs77153312 chr21:40695499 G/A cg11644478 chr21:40555479 PSMG1 0.83 18.38 0.59 7.03e-61 Cognitive function; BRCA cis rs7264396 0.563 rs59064961 chr20:34307950 T/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.68 -12.08 -0.43 2.06e-30 Total cholesterol levels; BRCA cis rs3806843 0.966 rs2337516 chr5:140140853 A/G cg16179182 chr5:140090404 VTRNA1-1 0.45 10.36 0.38 2.36e-23 Depressive symptoms (multi-trait analysis); BRCA cis rs524281 0.692 rs10791845 chr11:65834340 C/G cg16950941 chr11:66035639 RAB1B 0.4 8.86 0.33 7.79e-18 Electroencephalogram traits; BRCA cis rs10028773 0.546 rs13117947 chr4:120257060 A/G cg09307838 chr4:120376055 NA 0.43 9.2 0.34 4.85e-19 Educational attainment; BRCA cis rs875971 0.545 rs2279757 chr7:65828663 T/C cg11764359 chr7:65958608 NA 0.63 10.74 0.39 7.39e-25 Aortic root size; BRCA cis rs67311347 0.713 rs9861194 chr3:40309225 C/T cg09455208 chr3:40491958 NA 0.41 9.53 0.35 3.32e-20 Renal cell carcinoma; BRCA cis rs3820928 0.874 rs10210997 chr2:227859108 C/T cg11843606 chr2:227700838 RHBDD1 -0.39 -8.58 -0.32 7.03e-17 Pulmonary function; BRCA trans rs7980799 0.711 rs1482993 chr12:33594515 G/A cg26384229 chr12:38710491 ALG10B -0.52 -10.99 -0.4 7.31e-26 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs7246657 0.722 rs2972458 chr19:38135403 T/C cg23950597 chr19:37808831 NA 0.51 8.83 0.33 9.83e-18 Coronary artery calcification; BRCA trans rs9329221 0.868 rs7831557 chr8:10280228 C/T cg15556689 chr8:8085844 FLJ10661 -0.43 -11.16 -0.4 1.59e-26 Neuroticism; BRCA cis rs8180040 0.647 rs57756484 chr3:47239333 A/G cg27129171 chr3:47204927 SETD2 -0.71 -17.4 -0.57 8.85e-56 Colorectal cancer; BRCA cis rs6815814 0.950 rs3924112 chr4:38795810 C/T cg06935464 chr4:38784597 TLR10 0.51 8.24 0.31 9.92e-16 Breast cancer; BRCA cis rs6545883 0.708 rs2518936 chr2:61792342 T/C cg15711740 chr2:61764176 XPO1 -0.48 -11.68 -0.42 1.04e-28 Tuberculosis; BRCA cis rs9325144 0.560 rs12424821 chr12:38649951 C/T cg26384229 chr12:38710491 ALG10B -0.55 -13.58 -0.47 4.27e-37 Morning vs. evening chronotype; BRCA cis rs3820928 0.874 rs7594505 chr2:227878562 C/G cg11843606 chr2:227700838 RHBDD1 -0.38 -8.38 -0.31 3.33e-16 Pulmonary function; BRCA cis rs2710642 0.821 rs56373728 chr2:63095792 G/A cg17519650 chr2:63277830 OTX1 0.39 8.59 0.32 6.7e-17 LDL cholesterol levels;LDL cholesterol; BRCA cis rs208515 0.525 rs9453538 chr6:66668508 G/A cg07460842 chr6:66804631 NA 0.86 15.39 0.52 1.02e-45 Exhaled nitric oxide levels; BRCA cis rs523522 0.924 rs11065150 chr12:120958875 T/G cg12219531 chr12:120966889 COQ5 0.55 11.43 0.41 1.17e-27 High light scatter reticulocyte count; BRCA cis rs78456975 0.943 rs13421238 chr2:1576879 G/A cg26248373 chr2:1572462 NA -0.46 -8.63 -0.32 4.73e-17 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs12477438 0.748 rs10200974 chr2:99675227 A/G cg26064155 chr2:99771622 LIPT1;TSGA10 -0.65 -15.51 -0.52 2.78e-46 Chronic sinus infection; BRCA cis rs11190604 1.000 rs75063298 chr10:102213600 C/A cg07080220 chr10:102295463 HIF1AN 0.49 11.15 0.4 1.7e-26 Palmitoleic acid (16:1n-7) levels; BRCA cis rs12367572 0.601 rs1495036 chr12:45410643 T/C cg04608330 chr12:45269318 NELL2 -0.45 -9.87 -0.36 1.7e-21 Gut microbiome composition (summer); BRCA cis rs2842992 0.715 rs2277073 chr6:160182749 G/A cg16489826 chr6:160211363 TCP1;MRPL18 0.61 12.85 0.45 9.05e-34 Age-related macular degeneration (geographic atrophy); BRCA cis rs7766436 0.885 rs4711020 chr6:22582920 A/G cg13666174 chr6:22585274 NA -0.49 -11.63 -0.42 1.65e-28 Coronary artery disease; BRCA cis rs2073300 0.609 rs6137929 chr20:23376357 G/A cg12062639 chr20:23401060 NAPB 0.96 13.42 0.47 2.36e-36 Peripheral arterial disease (traffic-related air pollution interaction); BRCA cis rs9486719 0.857 rs13208321 chr6:96860354 C/T cg06623918 chr6:96969491 KIAA0776 -0.55 -11.64 -0.42 1.61e-28 Migraine;Coronary artery disease; BRCA cis rs17125944 0.542 rs75723366 chr14:53256882 T/C cg00686598 chr14:53173677 PSMC6 1.2 16.3 0.54 3.21e-50 Alzheimer's disease (late onset); BRCA cis rs909002 0.789 rs3817398 chr1:32119431 C/T cg01639898 chr1:32083012 HCRTR1 -0.29 -8.68 -0.32 3.27e-17 Intelligence (multi-trait analysis); BRCA cis rs3806843 0.735 rs702394 chr5:140086786 A/G cg26395211 chr5:140044315 WDR55 0.37 8.56 0.32 8.62e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs736408 0.774 rs4687551 chr3:52823448 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 -0.38 -7.97 -0.3 7.58e-15 Bipolar disorder; BRCA cis rs6952808 0.595 rs3778984 chr7:2166514 T/C cg04267008 chr7:1944627 MAD1L1 -0.6 -12.55 -0.44 1.94e-32 Bipolar disorder and schizophrenia; BRCA cis rs9814567 1.000 rs7611611 chr3:134307877 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 -0.39 -9.06 -0.34 1.6e-18 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs10256972 0.577 rs4999286 chr7:1199506 C/G cg26608667 chr7:1196370 ZFAND2A 0.44 10.62 0.39 2.23e-24 Longevity;Endometriosis; BRCA cis rs7249142 0.562 rs1050544 chr19:19287901 A/G cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.46 -11.18 -0.4 1.26e-26 IgG glycosylation; BRCA trans rs2727020 0.553 rs7479975 chr11:49581964 C/G cg15704280 chr7:45808275 SEPT13 -0.88 -23.34 -0.68 1.33e-87 Coronary artery disease; BRCA cis rs7264396 0.790 rs3787168 chr20:34233278 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.37 7.98 0.3 6.79e-15 Total cholesterol levels; BRCA cis rs6815814 0.950 rs5743571 chr4:38805489 C/T cg02016764 chr4:38805732 TLR1 -0.61 -9.73 -0.36 5.9e-21 Breast cancer; BRCA cis rs9787249 0.957 rs7518431 chr1:40214944 C/T cg02773041 chr1:40204384 PPIE -0.43 -9.44 -0.35 6.62e-20 Blood protein levels; BRCA cis rs1941023 0.503 rs7952244 chr11:60132164 G/A cg08716584 chr11:60157161 MS4A7 -0.44 -10.23 -0.38 7.45e-23 Congenital heart disease (maternal effect); BRCA cis rs10504229 0.683 rs72649192 chr8:58110490 T/C cg24829409 chr8:58192753 C8orf71 -0.46 -8.01 -0.3 5.36e-15 Developmental language disorder (linguistic errors); BRCA cis rs34779708 0.931 rs4934704 chr10:35332164 C/T cg03585969 chr10:35415529 CREM 0.48 10.12 0.37 1.98e-22 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1008375 1.000 rs1860596 chr4:17660082 C/T cg16339924 chr4:17578868 LAP3 0.6 14.83 0.51 5.67e-43 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs1552244 0.882 rs17081288 chr3:10042113 A/G cg16606324 chr3:10149918 C3orf24 0.5 9.56 0.35 2.53e-20 Alzheimer's disease; BRCA cis rs9811920 0.625 rs9868170 chr3:99914139 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.38 8.59 0.32 6.63e-17 Axial length; BRCA trans rs4689592 0.554 rs3951346 chr4:7073321 C/T cg07817883 chr1:32538562 TMEM39B -0.44 -8.57 -0.32 8.06e-17 Monocyte percentage of white cells; BRCA cis rs10911232 0.507 rs4652766 chr1:182994336 A/G ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.49e-52 Hypertriglyceridemia; BRCA cis rs9287719 0.967 rs6432118 chr2:10749441 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.95 -0.3 8.35e-15 Prostate cancer; BRCA trans rs1994135 0.669 rs2121831 chr12:33697674 G/A cg26384229 chr12:38710491 ALG10B 0.53 10.98 0.4 7.86e-26 Resting heart rate; BRCA cis rs4478858 0.735 rs6425737 chr1:31790288 T/C cg00250761 chr1:31883323 NA -0.33 -8.54 -0.32 9.88e-17 Alcohol dependence; BRCA cis rs6541297 1.000 rs4846839 chr1:230284924 A/G cg20703242 chr1:230279135 GALNT2 0.47 10.36 0.38 2.45e-23 Coronary artery disease; BRCA cis rs7945705 0.869 rs7925728 chr11:9013002 A/G cg21881798 chr11:8931708 C11orf17;ST5 -0.59 -14.17 -0.49 7.7e-40 Hemoglobin concentration; BRCA cis rs17270561 0.636 rs9348696 chr6:25781938 A/G cg17691542 chr6:26056736 HIST1H1C 0.49 9.99 0.37 6.29e-22 Iron status biomarkers; BRCA cis rs4891159 0.548 rs690082 chr18:74116668 C/T cg24786174 chr18:74118243 ZNF516 0.84 26.02 0.72 2.36e-102 Longevity; BRCA cis rs7552404 1.000 rs4949874 chr1:76161889 T/C cg03433033 chr1:76189801 ACADM 0.76 17.32 0.57 2.15e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs796364 0.806 rs10931887 chr2:200968905 G/A cg25936922 chr2:200820526 C2orf60;C2orf47 -0.69 -10.28 -0.38 4.63e-23 Schizophrenia; BRCA cis rs4665809 0.590 rs2303894 chr2:26508187 A/G cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.78 0.36 3.95e-21 Gut microbiome composition (summer); BRCA cis rs11719291 0.915 rs9834996 chr3:48754877 G/T cg00383909 chr3:49044727 WDR6 0.6 10.99 0.4 7.78e-26 Cognitive function; BRCA trans rs6089829 0.962 rs2277768 chr20:61666823 T/C cg15934090 chr1:100435551 SLC35A3 0.36 8.15 0.31 1.89e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs2645694 0.626 rs2703115 chr4:77824442 C/T cg18351406 chr4:77819688 ANKRD56 0.61 13.71 0.48 1.08e-37 Emphysema distribution in smoking; BRCA cis rs3862030 0.533 rs715440 chr10:104258095 A/T cg11453585 chr10:104263688 ACTR1A;SUFU -0.41 -11.87 -0.42 1.6800000000000001e-29 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction);Waist circumference adjusted for body mass index; BRCA cis rs897080 0.552 rs1067369 chr2:44652654 A/T cg18685995 chr2:44588913 PREPL;C2orf34 0.52 9.47 0.35 5.51e-20 Height; BRCA cis rs2549003 1.000 rs9282761 chr5:131822224 T/C cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA trans rs6479891 1.000 rs9415696 chr10:65134348 A/T cg14819942 chr15:35414228 NA 0.35 8.65 0.32 4.02e-17 Arthritis (juvenile idiopathic); BRCA trans rs941408 1.000 rs1640272 chr19:2800192 A/T cg19676328 chr12:49525230 TUBA1B -0.51 -11.45 -0.41 9.44e-28 Total cholesterol levels; BRCA cis rs4478858 0.735 rs34960310 chr1:31816197 A/G cg00250761 chr1:31883323 NA -0.33 -8.53 -0.32 1.02e-16 Alcohol dependence; BRCA trans rs1945213 0.694 rs34828123 chr11:55837868 T/A cg15704280 chr7:45808275 SEPT13 0.63 11.24 0.41 6.97e-27 Acute lymphoblastic leukemia (childhood); BRCA cis rs3845702 0.736 rs72962517 chr2:180861452 G/A cg01881094 chr2:180872142 CWC22 1.01 17.22 0.56 6.97e-55 Schizophrenia; BRCA cis rs9487051 0.698 rs35757653 chr6:109644599 A/C cg01475377 chr6:109611718 NA -0.49 -10.13 -0.37 1.76e-22 Reticulocyte fraction of red cells; BRCA cis rs9463078 0.774 rs9357484 chr6:45265882 C/A cg25276700 chr6:44698697 NA -0.35 -7.99 -0.3 6.29e-15 Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder; BRCA cis rs2739330 0.828 rs2877178 chr22:24251517 C/T cg10150615 chr22:24372951 LOC391322 -0.47 -10.71 -0.39 1.01e-24 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs9291683 0.530 rs13115193 chr4:9982191 C/T cg26043149 chr18:55253948 FECH 0.39 8.71 0.33 2.61e-17 Bone mineral density; BRCA cis rs1707322 0.721 rs12045096 chr1:46114428 A/G cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.54e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs3617 0.559 rs11915546 chr3:52866845 A/C cg11645453 chr3:52864694 ITIH4 -0.38 -10.07 -0.37 3.01e-22 Red blood cell count;Autism spectrum disorder or schizophrenia; BRCA cis rs769267 1.000 rs1009136 chr19:19440428 A/G cg01262667 chr19:19385393 TM6SF2 -0.41 -10.57 -0.39 3.52e-24 Tonsillectomy; BRCA cis rs7618915 0.547 rs6768697 chr3:52703615 C/T cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.83 0.39 3.19e-25 Bipolar disorder; BRCA cis rs2075371 1.000 rs2544221 chr7:133993014 G/C cg02659138 chr7:134003124 SLC35B4 0.34 10.73 0.39 8.25e-25 Mean platelet volume; BRCA cis rs2836974 0.897 rs2836929 chr21:40543811 T/C cg11644478 chr21:40555479 PSMG1 0.82 18.67 0.59 2.13e-62 Cognitive function; BRCA cis rs11955398 0.625 rs12655515 chr5:59974098 G/C cg02684056 chr5:59996105 DEPDC1B 0.39 9.06 0.34 1.55e-18 Intelligence (multi-trait analysis); BRCA cis rs10791323 0.604 rs2851116 chr11:133705759 G/A cg06766960 chr11:133703094 NA -0.61 -12.74 -0.45 2.64e-33 Childhood ear infection; BRCA cis rs7666738 0.830 rs10011009 chr4:98981749 G/A cg05340658 chr4:99064831 C4orf37 0.66 16.19 0.54 1.17e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs950169 0.614 rs12911536 chr15:84673030 G/T cg17507749 chr15:85114479 UBE2QP1 0.56 9.2 0.34 5.16e-19 Schizophrenia; BRCA cis rs1941023 0.606 rs7926219 chr11:60180335 C/T cg08716584 chr11:60157161 MS4A7 -0.36 -8.46 -0.32 1.89e-16 Congenital heart disease (maternal effect); BRCA cis rs2153535 0.580 rs7747306 chr6:8453663 C/G cg21535247 chr6:8435926 SLC35B3 -0.4 -8.98 -0.33 3.03e-18 Motion sickness; BRCA cis rs1113500 0.933 rs10494089 chr1:108626695 T/G cg06207961 chr1:108661230 NA 0.45 11.04 0.4 4.5e-26 Growth-regulated protein alpha levels; BRCA cis rs7254827 0.737 rs16981567 chr19:17152552 C/T cg19418318 chr19:17219073 MYO9B 0.47 9.84 0.36 2.36e-21 Mean platelet volume; BRCA cis rs7474896 0.515 rs2749582 chr10:38275284 A/G cg25427524 chr10:38739819 LOC399744 0.52 9.67 0.36 9.73e-21 Obesity (extreme); BRCA cis rs10540 1.000 rs61876326 chr11:467368 A/G cg19913688 chr11:428466 ANO9 -0.67 -9.76 -0.36 4.67e-21 Body mass index; BRCA cis rs7666738 0.924 rs11097592 chr4:98927532 C/T cg05340658 chr4:99064831 C4orf37 0.58 11.84 0.42 2.15e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs2147904 0.933 rs783621 chr1:42368035 A/G cg16685388 chr1:42384056 HIVEP3 0.34 9.69 0.36 8.49e-21 Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Sum eosinophil basophil counts;Eosinophil percentage of white cells;Eosinophil counts; BRCA cis rs7552404 0.690 rs11161620 chr1:76255228 A/G cg03433033 chr1:76189801 ACADM -0.71 -14.12 -0.49 1.37e-39 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7043114 0.525 rs7853859 chr9:95151377 A/G cg14631576 chr9:95140430 CENPP -0.33 -8.17 -0.31 1.71e-15 Height; BRCA cis rs854765 0.583 rs2350977 chr17:17802779 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 0.43 12.45 0.44 5.33e-32 Total body bone mineral density; BRCA cis rs9400271 0.632 rs9386784 chr6:109591208 C/A cg21918786 chr6:109611834 NA -0.32 -8.08 -0.3 3.17e-15 Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;White blood cell count;Neutrophil count;Myeloid white cell count;Granulocyte count; BRCA cis rs4363385 0.747 rs6684188 chr1:152974285 A/G cg25856811 chr1:152973957 SPRR3 -0.35 -9.3 -0.35 2.23e-19 Inflammatory skin disease; BRCA cis rs9296092 0.560 rs7765393 chr6:33525598 A/T cg13560919 chr6:33536144 NA -0.85 -18.96 -0.6 5.84e-64 Age at smoking initiation in chronic obstructive pulmonary disease; BRCA cis rs9790314 1.000 rs9846756 chr3:160983809 A/C cg04691961 chr3:161091175 C3orf57 -0.6 -14.18 -0.49 7.02e-40 Morning vs. evening chronotype; BRCA cis rs6940638 0.513 rs4424065 chr6:27036456 C/T cg12292205 chr6:26970375 C6orf41 -0.54 -11.88 -0.43 1.45e-29 Intelligence (multi-trait analysis); BRCA cis rs13118159 0.550 rs4974617 chr4:1373658 T/C cg16405210 chr4:1374714 KIAA1530 -0.93 -22.13 -0.66 5.35e-81 Longevity; BRCA cis rs870825 0.616 rs28660669 chr4:185623312 C/T cg04058563 chr4:185651563 MLF1IP 0.78 17.4 0.57 8.51e-56 Blood protein levels; BRCA cis rs2204008 0.616 rs1607852 chr12:38398125 G/A cg26384229 chr12:38710491 ALG10B 0.76 17.14 0.56 1.77e-54 Bladder cancer; BRCA cis rs524281 0.861 rs12226649 chr11:65842047 T/C cg16950941 chr11:66035639 RAB1B -0.38 -7.87 -0.3 1.58e-14 Electroencephalogram traits; BRCA cis rs1865760 1.000 rs9467636 chr6:25919549 A/C cg16482183 chr6:26056742 HIST1H1C 0.55 11.44 0.41 1.11e-27 Height; BRCA cis rs7395581 0.959 rs2013867 chr11:47260272 A/G cg25783544 chr11:47291846 MADD 0.4 8.96 0.33 3.54e-18 HDL cholesterol; BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg21747090 chr2:27597821 SNX17 -0.43 -9.43 -0.35 7.24e-20 Total body bone mineral density; BRCA cis rs10256972 0.567 rs2960835 chr7:1202963 A/G cg04025307 chr7:1156635 C7orf50 0.62 15.69 0.53 3.5e-47 Longevity;Endometriosis; BRCA cis rs798554 1.000 rs798545 chr7:2762386 C/T cg23285459 chr7:2802560 GNA12 -0.35 -8.52 -0.32 1.16e-16 Height; BRCA cis rs3858526 0.920 rs11039548 chr11:5930283 G/A cg25319279 chr11:5960081 NA -0.43 -8.38 -0.31 3.28e-16 DNA methylation (variation); BRCA cis rs2070433 0.539 rs2839312 chr21:47958225 T/C cg12379764 chr21:47803548 PCNT 0.56 11.99 0.43 5.14e-30 Lymphocyte counts; BRCA cis rs2070488 0.965 rs2154778 chr3:38553639 C/T cg24069376 chr3:38537580 EXOG -0.41 -11.73 -0.42 6.34e-29 Electrocardiographic conduction measures; BRCA cis rs4819052 0.851 rs10470246 chr21:46659017 C/G cg06618935 chr21:46677482 NA -0.38 -8.39 -0.32 3.11e-16 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs8114671 0.562 rs6119545 chr20:33522869 T/C cg24642439 chr20:33292090 TP53INP2 0.43 9.12 0.34 1.01e-18 Height; BRCA trans rs7824557 1.000 rs7824557 chr8:11104111 C/T cg15556689 chr8:8085844 FLJ10661 -0.38 -9.45 -0.35 6.15e-20 Retinal vascular caliber; BRCA cis rs9790314 0.846 rs1478568 chr3:161014276 C/T cg04691961 chr3:161091175 C3orf57 -0.44 -10.58 -0.39 3.26e-24 Morning vs. evening chronotype; BRCA cis rs651907 0.557 rs13066768 chr3:101486920 A/T cg21474964 chr3:101395104 ZBTB11;LOC100009676 -0.59 -14.52 -0.5 1.7e-41 Colorectal cancer; BRCA cis rs7631605 0.836 rs4678938 chr3:37181015 G/C cg15934958 chr3:37212084 LRRFIP2 0.39 9.21 0.34 4.48e-19 Cerebrospinal P-tau181p levels; BRCA cis rs524281 0.861 rs10896080 chr11:65876796 G/A cg16950941 chr11:66035639 RAB1B -0.39 -8.2 -0.31 1.35e-15 Electroencephalogram traits; BRCA cis rs765787 0.530 rs1648286 chr15:45517386 G/C cg24006582 chr15:45444508 DUOX1 -0.55 -11.28 -0.41 4.73e-27 Uric acid levels; BRCA cis rs9287719 0.934 rs6706763 chr2:10751407 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.93 -0.3 9.52e-15 Prostate cancer; BRCA cis rs10256972 0.641 rs12702017 chr7:1129413 C/T cg09177884 chr7:1199841 ZFAND2A -0.49 -10.62 -0.39 2.25e-24 Longevity;Endometriosis; BRCA cis rs4819052 0.851 rs4818768 chr21:46659818 T/A cg06618935 chr21:46677482 NA -0.37 -7.99 -0.3 6.28e-15 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9811920 0.535 rs704577 chr3:99487375 T/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.8 -0.36 3.35e-21 Axial length; BRCA cis rs7249142 0.512 rs12981160 chr19:19298099 T/A cg26504305 chr19:19281019 LOC729991-MEF2B;MEF2B -0.43 -10.23 -0.38 7.73e-23 IgG glycosylation; BRCA cis rs514406 0.560 rs1889033 chr1:53211887 A/G cg08859206 chr1:53392774 SCP2 0.43 8.58 0.32 7.2e-17 Monocyte count; BRCA cis rs4631830 0.720 rs2611475 chr10:51503178 G/A cg20129853 chr10:51489980 NA -0.32 -8.4 -0.32 2.98e-16 Prostate-specific antigen levels; BRCA cis rs6860806 0.603 rs112300250 chr5:131583292 G/A cg14196790 chr5:131705035 SLC22A5 0.35 9.29 0.34 2.43e-19 Breast cancer; BRCA cis rs3824867 0.770 rs11820680 chr11:47452744 C/T cg20307385 chr11:47447363 PSMC3 -0.51 -11.48 -0.41 6.99e-28 Mean corpuscular hemoglobin; BRCA cis rs965469 0.779 rs6037566 chr20:3331414 A/C cg25506879 chr20:3388711 C20orf194 -0.43 -8.74 -0.33 2.11e-17 IFN-related cytopenia; BRCA trans rs2797160 1.000 rs1418951 chr6:125996185 A/G cg05039488 chr6:79577232 IRAK1BP1 -0.35 -7.88 -0.3 1.41e-14 Endometrial cancer; BRCA cis rs514406 0.929 rs557847 chr1:53333116 A/G cg08859206 chr1:53392774 SCP2 -0.51 -11.07 -0.4 3.55e-26 Monocyte count; BRCA cis rs9649213 0.574 rs7802541 chr7:97933855 C/A cg24562669 chr7:97807699 LMTK2 0.46 12.44 0.44 5.67e-32 Prostate cancer (SNP x SNP interaction); BRCA cis rs875971 0.800 rs427557 chr7:65519250 A/G cg18876405 chr7:65276391 NA 0.58 14.01 0.48 4.47e-39 Aortic root size; BRCA cis rs1707322 1.000 rs10890375 chr1:46406581 G/A cg03146154 chr1:46216737 IPP 0.46 10.04 0.37 3.97e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs933688 1.000 rs11950530 chr5:90688740 A/G cg02339078 chr5:90679543 LOC100129716;ARRDC3 0.88 18.9 0.6 1.21e-63 Smoking behavior; BRCA trans rs3749237 1.000 rs3749237 chr3:49770032 C/T cg21659725 chr3:3221576 CRBN 0.49 11.64 0.42 1.62e-28 Resting heart rate; BRCA cis rs1552244 1.000 rs67006488 chr3:10152993 T/C cg16606324 chr3:10149918 C3orf24 0.56 11.15 0.4 1.74e-26 Alzheimer's disease; BRCA cis rs2153535 0.580 rs6905237 chr6:8471790 A/T cg21535247 chr6:8435926 SLC35B3 0.39 8.85 0.33 8.55e-18 Motion sickness; BRCA cis rs7598759 0.712 rs12991636 chr2:232333666 T/C cg19187155 chr2:232395269 NMUR1 0.39 8.2 0.31 1.33e-15 Noise-induced hearing loss; BRCA cis rs4803455 0.586 rs4803457 chr19:41861359 T/C cg09537434 chr19:41945824 ATP5SL -0.61 -12.81 -0.45 1.37e-33 Migraine;Coronary artery disease; BRCA cis rs6459804 0.967 rs4289696 chr7:157508399 C/T cg05731713 chr7:157510257 PTPRN2 0.39 10.0 0.37 5.7e-22 Bipolar disorder and schizophrenia; BRCA cis rs9811920 0.809 rs13059754 chr3:99678490 C/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.55 -13.49 -0.47 1.14e-36 Axial length; BRCA cis rs6120849 0.754 rs3818253 chr20:33596876 C/T cg24642439 chr20:33292090 TP53INP2 0.58 10.08 0.37 2.95e-22 Protein C levels; BRCA cis rs897984 0.542 rs7294 chr16:31102321 A/G cg02466173 chr16:30829666 NA 0.45 10.31 0.38 3.79e-23 Dementia with Lewy bodies; BRCA cis rs9309711 0.666 rs6723101 chr2:3484443 T/C cg10845886 chr2:3471009 TTC15 -0.54 -12.22 -0.44 5.48e-31 Neurofibrillary tangles; BRCA cis rs4925325 1.000 rs4925325 chr20:60514224 G/A cg12751644 chr20:60527061 NA 0.39 8.39 0.32 3.06e-16 Obesity-related traits; BRCA cis rs1113500 0.862 rs3853494 chr1:108637334 G/A cg06207961 chr1:108661230 NA 0.45 11.07 0.4 3.47e-26 Growth-regulated protein alpha levels; BRCA cis rs4819052 0.851 rs4819040 chr21:46659762 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.52 11.05 0.4 4.16e-26 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs12200560 0.505 rs211182 chr6:97074513 G/A cg06623918 chr6:96969491 KIAA0776 0.53 12.69 0.45 4.72e-33 Coronary heart disease; BRCA trans rs8073060 0.572 rs1634683 chr17:33941560 G/C cg19694781 chr19:47549865 TMEM160 -1.01 -20.54 -0.63 2.33e-72 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs4727027 0.754 rs917124 chr7:148851213 C/T cg23583168 chr7:148888333 NA -0.73 -15.84 -0.53 6.47e-48 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs4808199 0.895 rs8105094 chr19:19374061 C/T cg03709012 chr19:19516395 GATAD2A 0.95 15.92 0.53 2.49e-48 Nonalcoholic fatty liver disease; BRCA cis rs7246657 0.551 rs12972146 chr19:37626095 G/T cg18154014 chr19:37997991 ZNF793 0.51 8.21 0.31 1.2e-15 Coronary artery calcification; BRCA cis rs6952808 0.692 rs60755037 chr7:2030104 G/A cg22963979 chr7:1858916 MAD1L1 -0.38 -8.17 -0.31 1.61e-15 Bipolar disorder and schizophrenia; BRCA cis rs801193 0.935 rs2659899 chr7:66186721 A/G cg18876405 chr7:65276391 NA 0.62 15.26 0.52 4.8e-45 Aortic root size; BRCA cis rs6460942 0.915 rs79232243 chr7:12459494 G/A cg06484146 chr7:12443880 VWDE -0.75 -10.62 -0.39 2.31e-24 Coronary artery disease; BRCA trans rs561341 0.882 rs2428337 chr17:30299467 C/T cg27661571 chr11:113659931 NA -0.73 -11.16 -0.4 1.58e-26 Hip circumference adjusted for BMI; BRCA cis rs372883 0.648 rs15092 chr21:30718201 G/A cg08807101 chr21:30365312 RNF160 -0.39 -8.49 -0.32 1.4e-16 Pancreatic cancer; BRCA cis rs7264396 1.000 rs224434 chr20:34153856 A/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.45 -9.41 -0.35 8.86e-20 Total cholesterol levels; BRCA cis rs3733585 0.699 rs10001964 chr4:9959275 C/T cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.3e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs780096 0.587 rs6760828 chr2:27579231 T/C cg24768116 chr2:27665128 KRTCAP3 -0.32 -8.18 -0.31 1.52e-15 Total body bone mineral density; BRCA cis rs6912958 0.684 rs2787893 chr6:88387359 C/G cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.4 -0.32 2.87e-16 Monocyte percentage of white cells; BRCA cis rs12701220 0.655 rs7778968 chr7:1144622 C/G cg00990874 chr7:1149470 C7orf50 -0.6 -12.52 -0.44 2.49e-32 Bronchopulmonary dysplasia; BRCA cis rs10504229 1.000 rs117231141 chr8:58185465 A/G cg24829409 chr8:58192753 C8orf71 -0.6 -12.53 -0.44 2.33e-32 Developmental language disorder (linguistic errors); BRCA cis rs4555082 0.874 rs2816625 chr14:105734565 G/A cg10792982 chr14:105748885 BRF1 0.5 11.39 0.41 1.67e-27 Mean platelet volume;Platelet distribution width; BRCA cis rs7178572 0.568 rs12914345 chr15:77670401 A/C cg22256960 chr15:77711686 NA -0.4 -8.66 -0.32 3.78e-17 Type 2 diabetes; BRCA cis rs35306767 0.903 rs61830933 chr10:934195 G/A cg26597838 chr10:835615 NA 1.31 21.35 0.65 9.17e-77 Eosinophil percentage of granulocytes; BRCA cis rs2153535 0.580 rs915352 chr6:8442766 G/A cg21535247 chr6:8435926 SLC35B3 0.4 9.05 0.34 1.66e-18 Motion sickness; BRCA cis rs6088580 0.524 rs1853056 chr20:33262058 C/T cg07148914 chr20:33460835 GGT7 -0.36 -7.89 -0.3 1.35e-14 Glomerular filtration rate (creatinine); BRCA cis rs2235642 0.893 rs2076445 chr16:1592266 A/T cg26528668 chr16:1614120 IFT140 0.38 8.55 0.32 9.08e-17 Coronary artery disease; BRCA cis rs9300255 0.722 rs34997336 chr12:123829116 G/A cg00376283 chr12:123451042 ABCB9 -0.49 -11.21 -0.41 9.52e-27 Neutrophil percentage of white cells; BRCA cis rs290268 0.838 rs1319677 chr9:93565999 A/G cg02608019 chr9:93564028 SYK 0.55 12.26 0.44 3.35e-31 Platelet count; BRCA cis rs7949030 0.591 rs11231156 chr11:62366454 G/A cg22862634 chr11:62369728 EML3;MTA2 0.57 13.62 0.47 2.81e-37 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA trans rs1493916 0.837 rs2172626 chr18:31410478 C/T cg27147174 chr7:100797783 AP1S1 -0.42 -8.48 -0.32 1.55e-16 Life satisfaction; BRCA cis rs478304 0.651 rs11537193 chr11:65500003 A/C cg10518572 chr11:65560635 OVOL1 -0.28 -8.13 -0.31 2.19e-15 Acne (severe); BRCA cis rs4268898 0.662 rs12052954 chr2:24425620 C/T cg06627628 chr2:24431161 ITSN2 0.76 14.61 0.5 6.62e-42 Asthma; BRCA cis rs6138458 1.000 rs11905625 chr20:24977065 A/C cg06937882 chr20:24974362 C20orf3 -0.48 -9.46 -0.35 5.84e-20 Blood protein levels; BRCA cis rs2580764 0.598 rs6726158 chr2:55239202 G/T cg09592903 chr2:55203963 RTN4 -0.34 -8.75 -0.33 1.92e-17 Mean platelet volume; BRCA cis rs4319547 0.956 rs10773302 chr12:123043145 G/T cg05707623 chr12:122985044 ZCCHC8 -0.47 -9.7 -0.36 7.75e-21 Body mass index; BRCA cis rs2463822 1.000 rs951677 chr11:62107249 G/C cg06239285 chr11:62104954 ASRGL1 0.65 9.73 0.36 5.86e-21 Chronic obstructive pulmonary disease-related biomarkers; BRCA cis rs6088580 0.602 rs6058064 chr20:33086622 A/G cg24642439 chr20:33292090 TP53INP2 0.51 11.23 0.41 7.92e-27 Glomerular filtration rate (creatinine); BRCA cis rs9361491 0.621 rs12196457 chr6:79627743 A/T cg05283184 chr6:79620031 NA -0.35 -8.08 -0.3 3.18e-15 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.830 rs6825211 chr4:98807698 A/T cg05340658 chr4:99064831 C4orf37 0.62 14.95 0.51 1.57e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs11105298 0.786 rs10858867 chr12:89851166 C/T cg00757033 chr12:89920650 WDR51B 0.53 10.71 0.39 1.02e-24 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs35110281 0.807 rs2838328 chr21:45023234 G/C cg01579765 chr21:45077557 HSF2BP -0.38 -10.4 -0.38 1.61e-23 Mean corpuscular volume; BRCA cis rs782590 0.967 rs11125581 chr2:55796527 C/G cg18811423 chr2:55921094 PNPT1 0.72 23.02 0.67 7.54e-86 Metabolic syndrome; BRCA cis rs7647973 0.593 rs7620848 chr3:49828021 G/C cg03060546 chr3:49711283 APEH -0.59 -10.21 -0.37 9.07e-23 Menarche (age at onset); BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg02951883 chr7:2050386 MAD1L1 -0.49 -10.55 -0.39 4.1e-24 Bipolar disorder and schizophrenia; BRCA cis rs143000161 1 rs143000161 chr2:165710540 A/T cg03182029 chr2:165697222 COBLL1 0.54 10.11 0.37 2.13e-22 Heschl's gyrus morphology; BRCA cis rs6429082 0.818 rs291383 chr1:235643100 G/A cg26050004 chr1:235667680 B3GALNT2 0.57 14.15 0.49 9.77e-40 Adiposity; BRCA cis rs2516839 0.652 rs2516841 chr1:161010774 A/G cg19284575 chr1:160991224 F11R -0.45 -8.14 -0.31 2.14e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs780096 0.526 rs10182937 chr2:27651693 T/C cg17158414 chr2:27665306 KRTCAP3 -0.37 -9.67 -0.36 9.78e-21 Total body bone mineral density; BRCA cis rs6430585 0.528 rs7573555 chr2:136694905 C/T cg07169764 chr2:136633963 MCM6 -1.27 -26.18 -0.72 3.38e-103 Corneal structure; BRCA cis rs7959452 0.562 rs10878975 chr12:69782044 G/C cg14784868 chr12:69753453 YEATS4 0.68 19.79 0.62 2.42e-68 Blood protein levels; BRCA cis rs1801251 1.000 rs35212961 chr2:233582762 C/T cg25237894 chr2:233734115 C2orf82 0.39 11.0 0.4 6.9e-26 Coronary artery disease; BRCA cis rs35110281 0.681 rs162343 chr21:44957072 A/G cg21573476 chr21:45109991 RRP1B -0.36 -9.39 -0.35 1.01e-19 Mean corpuscular volume; BRCA cis rs7264396 0.790 rs2425096 chr20:34308588 A/G cg23207816 chr20:34252616 CPNE1;RBM12 0.38 8.14 0.31 2.04e-15 Total cholesterol levels; BRCA trans rs2727020 0.729 rs685789 chr11:49241228 G/A cg03929089 chr4:120376271 NA 0.8 18.63 0.59 3.48e-62 Coronary artery disease; BRCA cis rs9381040 0.610 rs2268195 chr6:41024340 G/A cg04346459 chr6:41068666 NFYA;LOC221442 -0.45 -10.0 -0.37 5.53e-22 Alzheimer's disease (late onset); BRCA cis rs769267 0.930 rs2288852 chr19:19605348 T/C cg19010396 chr19:19431384 KIAA0892;SF4 0.45 9.05 0.34 1.71e-18 Tonsillectomy; BRCA cis rs9811920 0.535 rs792837 chr3:99477182 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G -0.42 -9.96 -0.37 8.22e-22 Axial length; BRCA cis rs12142240 0.698 rs41293285 chr1:46808426 C/T cg14993813 chr1:46806288 NSUN4 -0.48 -9.21 -0.34 4.59e-19 Menopause (age at onset); BRCA cis rs854765 0.547 rs4368210 chr17:17896090 A/G cg24612305 chr17:17875800 TOM1L2;LRRC48 -0.61 -18.56 -0.59 7.46e-62 Total body bone mineral density; BRCA cis rs6539267 0.741 rs10861572 chr12:106688576 A/G cg02476566 chr12:106696527 TCP11L2 -0.51 -9.6 -0.36 1.71e-20 Tourette syndrome; BRCA cis rs2070488 0.775 rs2186457 chr3:38553965 A/G cg24069376 chr3:38537580 EXOG 0.31 8.69 0.32 3.14e-17 Electrocardiographic conduction measures; BRCA cis rs4819052 0.851 rs2838843 chr21:46669284 T/C cg19498844 chr21:46707878 POFUT2;LOC642852 0.63 13.86 0.48 2.15e-38 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs9325144 0.560 rs10785562 chr12:38637419 A/C cg26384229 chr12:38710491 ALG10B -0.55 -13.85 -0.48 2.47e-38 Morning vs. evening chronotype; BRCA cis rs6582630 0.555 rs12828034 chr12:38274249 C/T cg26384229 chr12:38710491 ALG10B -0.44 -10.0 -0.37 5.49e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs1577917 0.655 rs6454472 chr6:86224053 T/G cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A 0.38 10.59 0.39 2.87e-24 Response to antipsychotic treatment; BRCA cis rs10751667 0.666 rs10902239 chr11:946484 A/G cg10932868 chr11:921992 NA -0.49 -12.61 -0.45 1.03e-32 Alzheimer's disease (late onset); BRCA trans rs11098499 0.954 rs4577559 chr4:120404043 T/G cg25517755 chr10:38738941 LOC399744 -0.38 -7.93 -0.3 9.81e-15 Corneal astigmatism; BRCA cis rs992157 0.732 rs10932771 chr2:219170236 A/T cg00012203 chr2:219082015 ARPC2 0.5 10.2 0.37 9.9e-23 Colorectal cancer; BRCA cis rs2303759 0.709 rs8102658 chr19:49828855 C/T cg22307029 chr19:49891270 CCDC155 0.54 9.11 0.34 1.06e-18 Multiple sclerosis; BRCA cis rs798554 1.000 rs798540 chr7:2764130 G/A cg23285459 chr7:2802560 GNA12 -0.36 -8.79 -0.33 1.34e-17 Height; BRCA cis rs13046373 0.535 rs7281767 chr21:32022062 T/C cg24082983 chr21:31802169 KRTAP13-4 0.32 8.16 0.31 1.74e-15 HDL cholesterol; BRCA trans rs4596713 0.507 rs10217120 chr9:71794919 A/G cg16512924 chr15:28394682 HERC2 0.45 10.79 0.39 4.85e-25 Headache; BRCA cis rs2249625 0.874 rs2496534 chr6:72922550 C/T cg18830697 chr6:72922368 RIMS1 -0.38 -7.94 -0.3 9.15e-15 Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced); BRCA cis rs2836950 0.545 rs11701805 chr21:40618683 T/C cg11890956 chr21:40555474 PSMG1 -0.61 -13.77 -0.48 5.95e-38 Menarche (age at onset); BRCA trans rs11098499 0.954 rs10008392 chr4:120318839 G/A cg25214090 chr10:38739885 LOC399744 0.54 12.22 0.44 5.01e-31 Corneal astigmatism; BRCA trans rs61931739 0.534 rs10844725 chr12:34009504 C/A cg26384229 chr12:38710491 ALG10B 0.67 13.9 0.48 1.47e-38 Morning vs. evening chronotype; BRCA cis rs1707322 1.000 rs7532204 chr1:46485075 C/G cg03146154 chr1:46216737 IPP -0.45 -10.13 -0.37 1.84e-22 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs1862618 0.671 rs173763 chr5:56225418 G/A cg24549020 chr5:56110836 MAP3K1 0.41 8.58 0.32 7.34e-17 Initial pursuit acceleration; BRCA cis rs12701220 0.725 rs13242971 chr7:1055515 C/T cg00990874 chr7:1149470 C7orf50 -0.54 -9.66 -0.36 1.05e-20 Bronchopulmonary dysplasia; BRCA cis rs8072100 0.790 rs7222225 chr17:45693497 A/G cg19784903 chr17:45786737 TBKBP1 0.36 8.51 0.32 1.26e-16 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs10028773 0.700 rs7690338 chr4:120256468 C/G cg09307838 chr4:120376055 NA 0.64 13.76 0.48 6.34e-38 Educational attainment; BRCA cis rs698833 0.886 rs8886 chr2:44547909 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.53 -10.81 -0.39 3.8e-25 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2032447 0.613 rs6456708 chr6:26032847 G/C cg12310025 chr6:25882481 NA -0.35 -8.42 -0.32 2.45e-16 Intelligence (multi-trait analysis); BRCA cis rs10484885 0.648 rs2777848 chr6:90535993 G/A cg13799429 chr6:90582589 CASP8AP2 -0.88 -17.42 -0.57 6.58e-56 QRS interval (sulfonylurea treatment interaction); BRCA cis rs77972916 0.536 rs62137421 chr2:43594091 C/T cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.67 -10.88 -0.4 2.06e-25 Granulocyte percentage of myeloid white cells; BRCA cis rs4665809 0.838 rs2243834 chr2:26357748 A/C cg25036284 chr2:26402008 FAM59B 0.61 10.42 0.38 1.38e-23 Gut microbiome composition (summer); BRCA cis rs11711311 0.747 rs2895415 chr3:113345565 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.32 7.94 0.3 9.11e-15 IgG glycosylation; BRCA cis rs2842992 0.789 rs4276525 chr6:160193612 G/A cg11366901 chr6:160182831 ACAT2 0.83 16.08 0.54 4e-49 Age-related macular degeneration (geographic atrophy); BRCA cis rs9311474 0.508 rs17052259 chr3:52593138 A/G cg10802521 chr3:52805072 NEK4 -0.32 -8.56 -0.32 8.48e-17 Electroencephalogram traits; BRCA cis rs1552244 0.882 rs13089863 chr3:10032259 G/T cg02579736 chr3:10068473 FANCD2;CIDECP -0.83 -14.24 -0.49 3.66e-40 Alzheimer's disease; BRCA cis rs250677 1.000 rs250676 chr5:148425518 A/T cg18129178 chr5:148520854 ABLIM3 -0.55 -11.09 -0.4 2.8e-26 Breast cancer; BRCA cis rs9790314 1.000 rs6794601 chr3:160946769 C/T cg04691961 chr3:161091175 C3orf57 -0.51 -12.67 -0.45 5.78e-33 Morning vs. evening chronotype; BRCA cis rs250677 0.687 rs250678 chr5:148434830 C/T cg12140854 chr5:148520817 ABLIM3 -0.43 -9.2 -0.34 4.85e-19 Breast cancer; BRCA cis rs733175 0.904 rs3775944 chr4:10019974 G/T cg00071950 chr4:10020882 SLC2A9 0.41 7.91 0.3 1.17e-14 Psychosis and Alzheimer's disease; BRCA cis rs10262624 0.504 rs59865844 chr7:23733040 T/C cg05804949 chr7:23719620 C7orf46 0.37 7.85 0.3 1.76e-14 Schizophrenia; BRCA cis rs9392556 0.765 rs613709 chr6:4120683 G/A cg08342332 chr6:4079704 C6orf201;C6orf146 -0.38 -8.02 -0.3 4.96e-15 Blood metabolite levels; BRCA cis rs875971 0.862 rs2420173 chr7:65645399 A/T cg11764359 chr7:65958608 NA -0.77 -17.55 -0.57 1.38e-56 Aortic root size; BRCA trans rs17685 0.753 rs10251863 chr7:75790192 T/C cg19862616 chr7:65841803 NCRNA00174 0.81 25.64 0.71 3.13e-100 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs765787 0.530 rs4775831 chr15:45534722 A/C cg24006582 chr15:45444508 DUOX1 -0.55 -11.32 -0.41 3.43e-27 Uric acid levels; BRCA cis rs4595586 0.525 rs17464772 chr12:39247777 G/A cg13010199 chr12:38710504 ALG10B 0.44 8.5 0.32 1.31e-16 Morning vs. evening chronotype; BRCA cis rs35146811 0.555 rs2527896 chr7:99537653 A/G cg22906224 chr7:99728672 NA 0.42 7.8 0.3 2.44e-14 Coronary artery disease; BRCA cis rs7520050 0.966 rs7515491 chr1:46355079 A/G cg24296786 chr1:45957014 TESK2 0.4 9.15 0.34 7.45e-19 Red blood cell count;Reticulocyte count; BRCA cis rs3812565 0.506 rs8413 chr9:139323311 T/C cg14019695 chr9:139328340 INPP5E 0.45 11.83 0.42 2.37e-29 Granulocyte percentage of myeloid white cells; BRCA cis rs7666738 0.927 rs11736876 chr4:98987206 A/G cg05340658 chr4:99064831 C4orf37 0.59 11.9 0.43 1.29e-29 Colonoscopy-negative controls vs population controls; BRCA cis rs10256972 0.732 rs1574108 chr7:1105805 T/C cg18402987 chr7:1209562 NA 0.48 9.13 0.34 8.57e-19 Longevity;Endometriosis; BRCA cis rs6912958 0.525 rs59322 chr6:88020521 C/A cg04972856 chr6:88032051 C6orf162;GJB7 0.32 8.36 0.31 3.8e-16 Monocyte percentage of white cells; BRCA cis rs7829975 0.806 rs2428 chr8:8641145 C/T cg15556689 chr8:8085844 FLJ10661 0.41 11.9 0.43 1.21e-29 Mood instability; BRCA cis rs921968 0.565 rs13408305 chr2:219628183 G/A cg02176678 chr2:219576539 TTLL4 -0.41 -11.01 -0.4 6.4e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs13046373 0.507 rs11088139 chr21:31978884 T/G cg22337977 chr21:31811175 KRTAP15-1 0.35 8.36 0.31 4.03e-16 HDL cholesterol; BRCA trans rs330048 0.545 rs11774353 chr8:9153127 C/T cg08975724 chr8:8085496 FLJ10661 0.47 9.4 0.35 9.32e-20 Systemic lupus erythematosus; BRCA trans rs1973993 0.691 rs1980684 chr1:96890636 A/G cg10631902 chr5:14652156 NA 0.57 19.73 0.62 5.29e-68 Weight; BRCA cis rs501916 0.634 rs1045688 chr15:48065487 A/G cg16110827 chr15:48056943 SEMA6D 0.41 8.42 0.32 2.5e-16 Inflammatory bowel disease;Ulcerative colitis; BRCA trans rs9858542 1.000 rs34762726 chr3:49689210 G/A cg21659725 chr3:3221576 CRBN -0.49 -10.3 -0.38 3.95e-23 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs8177253 0.761 rs13079426 chr3:133522334 A/G cg01448562 chr3:133502909 NA -0.76 -19.03 -0.6 2.57e-64 Iron status biomarkers; BRCA cis rs2204008 0.604 rs2320521 chr12:38253789 A/G cg13010199 chr12:38710504 ALG10B 0.44 8.95 0.33 3.88e-18 Bladder cancer; BRCA cis rs2836974 0.568 rs452377 chr21:40537183 T/C cg11644478 chr21:40555479 PSMG1 0.67 15.13 0.51 1.9e-44 Cognitive function; BRCA cis rs2011503 1.000 rs11669558 chr19:19655670 C/T cg11584989 chr19:19387371 SF4 0.6 12.31 0.44 2.03e-31 Bipolar disorder; BRCA cis rs873946 0.586 rs12782567 chr10:134576709 C/G cg26818010 chr10:134567672 INPP5A 0.79 16.1 0.54 3.43e-49 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs4812048 0.846 rs151361 chr20:57614002 A/G cg14073986 chr20:57617431 SLMO2 0.43 8.26 0.31 8.13e-16 Mean platelet volume; BRCA cis rs895636 0.519 rs4953155 chr2:45189496 A/T cg16198908 chr2:45192207 NA -0.37 -8.06 -0.3 3.63e-15 Metabolite levels;Fasting plasma glucose; BRCA cis rs2276314 0.802 rs58906216 chr18:33630297 T/C cg19628046 chr18:33552617 C18orf21 0.53 10.37 0.38 2.07e-23 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs7829975 0.667 rs1877119 chr8:8707197 C/G cg06636001 chr8:8085503 FLJ10661 0.6 13.27 0.46 1.18e-35 Mood instability; BRCA cis rs1005277 0.540 rs2145487 chr10:38010077 A/G cg25427524 chr10:38739819 LOC399744 -0.65 -15.66 -0.53 5.27e-47 Extrinsic epigenetic age acceleration; BRCA cis rs2066819 0.892 rs112931321 chr12:56667894 C/T cg26714650 chr12:56694279 CS -1.19 -15.69 -0.53 3.47e-47 Psoriasis vulgaris; BRCA cis rs9388451 0.874 rs1159974 chr6:126090277 C/T cg05901451 chr6:126070800 HEY2 0.69 20.02 0.62 1.39e-69 Brugada syndrome; BRCA cis rs17401966 0.867 rs10492973 chr1:10398985 T/C cg03954927 chr1:10346856 KIF1B 0.44 13.98 0.48 5.84e-39 Hepatocellular carcinoma; BRCA cis rs2012796 0.956 rs7146802 chr14:81820515 A/G cg02996355 chr14:81879375 NA 0.51 9.82 0.36 2.77e-21 Night sleep phenotypes; BRCA cis rs2842992 0.789 rs7758895 chr6:160193465 T/C cg11366901 chr6:160182831 ACAT2 0.83 16.08 0.54 4e-49 Age-related macular degeneration (geographic atrophy); BRCA cis rs9287719 0.967 rs728134 chr2:10745187 A/G cg00105475 chr2:10696890 NA 0.44 10.41 0.38 1.51e-23 Prostate cancer; BRCA cis rs34779708 0.900 rs73262807 chr10:35496386 C/T cg03585969 chr10:35415529 CREM 0.49 10.38 0.38 2.0500000000000001e-23 Inflammatory bowel disease;Crohn's disease; BRCA cis rs1005277 0.522 rs9417256 chr10:37976990 A/G cg00409905 chr10:38381863 ZNF37A -0.47 -9.92 -0.37 1.16e-21 Extrinsic epigenetic age acceleration; BRCA cis rs2425143 0.643 rs6058324 chr20:34388789 G/T cg04508476 chr20:34239394 CPNE1;RBM12 -0.62 -9.07 -0.34 1.48e-18 Blood protein levels; BRCA cis rs11955398 0.585 rs1117674 chr5:60035007 T/C cg02684056 chr5:59996105 DEPDC1B -0.37 -8.95 -0.33 3.75e-18 Intelligence (multi-trait analysis); BRCA cis rs7944584 1.000 rs7944584 chr11:47336320 A/T cg20307385 chr11:47447363 PSMC3 0.62 12.14 0.43 1.18e-30 Fasting blood glucose;Fasting blood glucose (BMI interaction); BRCA cis rs262150 0.546 rs7798337 chr7:158801089 G/A cg23096020 chr7:158799433 NA 0.45 10.46 0.38 9.91e-24 Facial morphology (factor 20); BRCA cis rs4631830 0.600 rs11004324 chr10:51496623 G/T cg16070123 chr10:51489643 NA -0.37 -8.11 -0.31 2.63e-15 Prostate-specific antigen levels; BRCA cis rs7520050 0.966 rs11211234 chr1:46438787 C/A cg24296786 chr1:45957014 TESK2 0.44 9.76 0.36 4.56e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7727544 0.684 rs270602 chr5:131656700 T/C cg07395648 chr5:131743802 NA -0.4 -9.92 -0.37 1.1e-21 Blood metabolite levels; BRCA cis rs6952808 0.692 rs6950627 chr7:2086672 C/T cg14004847 chr7:1930337 MAD1L1 -0.41 -8.11 -0.31 2.66e-15 Bipolar disorder and schizophrenia; BRCA cis rs13191362 0.507 rs2803083 chr6:163111199 A/C cg06582575 chr6:163149167 PACRG;PARK2 0.5 9.4 0.35 9.96e-20 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs8072100 0.713 rs9895776 chr17:45486003 A/G cg25173405 chr17:45401733 C17orf57 -0.5 -10.5 -0.38 6.69e-24 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs614226 0.938 rs7972244 chr12:120994872 A/G cg27489772 chr12:121021490 NA 0.45 8.02 0.3 5.07e-15 Type 1 diabetes nephropathy; BRCA cis rs12893668 0.572 rs35011804 chr14:104151400 C/T cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.28 -0.38 4.68e-23 Reticulocyte count; BRCA cis rs1008375 0.932 rs11935124 chr4:17668200 G/A cg15017067 chr4:17643749 FAM184B -0.29 -8.57 -0.32 7.96e-17 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4819052 1.000 rs733739 chr21:46666210 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.64 11.58 0.42 2.86e-28 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs17376456 0.597 rs7728825 chr5:93384594 T/C cg25358565 chr5:93447407 FAM172A -0.5 -8.88 -0.33 6.68e-18 Diabetic retinopathy; BRCA cis rs4073582 0.595 rs708472 chr11:65930990 A/G cg14036092 chr11:66035641 RAB1B 0.39 10.56 0.39 4e-24 Gout; BRCA cis rs7618915 0.571 rs6778844 chr3:52596398 C/T cg10802521 chr3:52805072 NEK4 0.32 8.01 0.3 5.51e-15 Bipolar disorder; BRCA cis rs2832191 0.720 rs2832194 chr21:30494250 T/C cg24692254 chr21:30365293 RNF160 -0.64 -16.62 -0.55 7.79e-52 Dental caries; BRCA cis rs3818285 0.515 rs4918471 chr10:111660500 C/A cg00817464 chr10:111662876 XPNPEP1 -0.37 -9.79 -0.36 3.54e-21 Superior crus of antihelix expression; BRCA cis rs1005277 0.579 rs1780139 chr10:38503018 C/T cg00409905 chr10:38381863 ZNF37A -0.53 -11.43 -0.41 1.22e-27 Extrinsic epigenetic age acceleration; BRCA cis rs2130392 1.000 rs3796689 chr4:185649866 C/A cg04058563 chr4:185651563 MLF1IP 0.39 9.56 0.35 2.52e-20 Kawasaki disease; BRCA cis rs10193935 0.901 rs13384404 chr2:42601147 G/T cg27598129 chr2:42591480 NA -0.86 -14.34 -0.49 1.24e-40 Colonoscopy-negative controls vs population controls; BRCA trans rs561341 1.000 rs508192 chr17:30315147 C/T cg20587970 chr11:113659929 NA 1.13 21.13 0.64 1.56e-75 Hip circumference adjusted for BMI; BRCA cis rs4243830 0.850 rs12030607 chr1:6601007 T/A cg22792644 chr1:6614718 TAS1R1;NOL9 0.92 18.66 0.59 2.4e-62 Body mass index; BRCA cis rs7819412 0.595 rs4841500 chr8:10988275 A/G cg21775007 chr8:11205619 TDH -0.47 -9.81 -0.36 2.86e-21 Triglycerides; BRCA cis rs11676348 0.811 rs4674255 chr2:218987325 C/T cg06547715 chr2:218990976 CXCR2 0.32 8.01 0.3 5.29e-15 Ulcerative colitis; BRCA cis rs4665809 0.627 rs13032756 chr2:26489730 A/T cg27170947 chr2:26402098 FAM59B 0.93 16.76 0.55 1.67e-52 Gut microbiome composition (summer); BRCA cis rs1267303 0.642 rs61783087 chr1:46999955 T/C cg25110126 chr1:46999211 NA 0.74 13.82 0.48 3.45e-38 Monobrow; BRCA cis rs7666738 0.800 rs28427190 chr4:98989106 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.35 0.57 1.52e-55 Colonoscopy-negative controls vs population controls; BRCA cis rs2204008 0.805 rs10881112 chr12:37956611 G/A cg26384229 chr12:38710491 ALG10B -0.56 -13.19 -0.46 2.72e-35 Bladder cancer; BRCA cis rs7666738 0.800 rs13107147 chr4:99028753 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.69 0.39 1.22e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs4665809 0.556 rs1560869 chr2:26417095 T/C cg22920501 chr2:26401640 FAM59B -0.9 -16.11 -0.54 3.04e-49 Gut microbiome composition (summer); BRCA cis rs16976116 0.901 rs1061870 chr15:55496769 G/T cg11288833 chr15:55489084 RSL24D1 0.47 10.67 0.39 1.37e-24 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs4862750 0.914 rs9995391 chr4:187873749 A/T cg03452623 chr4:187889614 NA 0.35 11.52 0.41 4.77e-28 Lobe attachment (rater-scored or self-reported); BRCA cis rs4332037 0.851 rs73050128 chr7:1961882 C/A cg12591125 chr7:1885375 MAD1L1 0.46 7.85 0.3 1.8e-14 Bipolar disorder; BRCA cis rs6973256 0.897 rs9656422 chr7:133324665 C/T cg07491979 chr7:133331646 EXOC4 -0.38 -8.74 -0.33 2.03e-17 Intelligence (multi-trait analysis); BRCA cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg00080972 chr5:178986291 RUFY1 0.37 8.43 0.32 2.37e-16 Lung cancer; BRCA trans rs3733585 0.673 rs7434391 chr4:9967682 C/G cg26043149 chr18:55253948 FECH -0.38 -8.34 -0.31 4.43e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs877282 0.945 rs10904555 chr10:787740 C/A cg17470449 chr10:769945 NA 0.51 8.63 0.32 4.87e-17 Uric acid levels; BRCA cis rs12586317 0.514 rs74590021 chr14:35490113 T/G cg16230307 chr14:35515116 FAM177A1 0.73 15.16 0.51 1.44e-44 Psoriasis; BRCA cis rs2075671 0.903 rs11979818 chr7:100293639 A/G cg20848291 chr7:100343083 ZAN 0.64 13.62 0.47 2.83e-37 Other erythrocyte phenotypes; BRCA cis rs12479064 0.694 rs4341989 chr2:100046783 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 -0.45 -9.18 -0.34 6.07e-19 Chronic sinus infection; BRCA cis rs10504229 0.728 rs17216187 chr8:58158778 G/T cg08219700 chr8:58056026 NA 0.54 8.9 0.33 5.58e-18 Developmental language disorder (linguistic errors); BRCA cis rs60871478 1.000 rs9195 chr7:825786 C/T cg27478167 chr7:817139 HEATR2 0.44 9.59 0.35 1.95e-20 Cerebrospinal P-tau181p levels; BRCA cis rs4975709 0.610 rs4975704 chr5:1859807 C/A cg20790798 chr5:1857306 NA -0.39 -9.16 -0.34 6.78e-19 Cardiovascular disease risk factors; BRCA cis rs9790314 0.502 rs2404342 chr3:161092562 C/T cg03342759 chr3:160939853 NMD3 -0.72 -16.24 -0.54 6.41e-50 Morning vs. evening chronotype; BRCA cis rs2404602 0.735 rs11857327 chr15:76764263 G/C cg23625390 chr15:77176239 SCAPER -0.51 -11.94 -0.43 8.44e-30 Blood metabolite levels; BRCA cis rs1008375 0.898 rs10008445 chr4:17593978 G/T cg15017067 chr4:17643749 FAM184B 0.34 10.35 0.38 2.6e-23 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4332037 0.539 rs11763750 chr7:2080114 G/A cg23422044 chr7:1970798 MAD1L1 -0.59 -10.75 -0.39 7.18e-25 Bipolar disorder; BRCA cis rs7666738 0.791 rs7678564 chr4:99057341 A/G cg05340658 chr4:99064831 C4orf37 0.69 17.41 0.57 7.61e-56 Colonoscopy-negative controls vs population controls; BRCA trans rs61931739 0.500 rs11053242 chr12:34511625 A/G cg13010199 chr12:38710504 ALG10B 0.43 9.11 0.34 1.04e-18 Morning vs. evening chronotype; BRCA cis rs6912958 1.000 rs9450701 chr6:88173167 T/C cg12350822 chr6:88032061 C6orf162;GJB7 -0.34 -9.82 -0.36 2.79e-21 Monocyte percentage of white cells; BRCA cis rs155076 1.000 rs155076 chr13:21870114 A/G cg06138931 chr13:21896616 NA -0.5 -8.63 -0.32 4.68e-17 White matter hyperintensity burden; BRCA cis rs2880765 0.835 rs4281668 chr15:86047286 C/T cg10818794 chr15:86012489 AKAP13 -0.29 -7.82 -0.3 2.13e-14 Coronary artery disease; BRCA cis rs17253792 0.822 rs11546 chr14:56146357 G/A cg01858014 chr14:56050164 KTN1 -0.75 -10.26 -0.38 5.89e-23 Putamen volume; BRCA cis rs9640161 0.830 rs3757424 chr7:150067679 C/A cg21361702 chr7:150065534 REPIN1 0.51 10.44 0.38 1.13e-23 Blood protein levels;Circulating chemerin levels; BRCA cis rs60871478 0.636 rs4719520 chr7:875216 C/G cg05535760 chr7:792225 HEATR2 -0.71 -11.42 -0.41 1.24e-27 Cerebrospinal P-tau181p levels; BRCA trans rs7613875 0.600 rs1061474 chr3:50144951 T/C cg21659725 chr3:3221576 CRBN -0.35 -8.07 -0.3 3.45e-15 Body mass index; BRCA cis rs514406 0.679 rs61768344 chr1:53229274 G/A cg16325326 chr1:53192061 ZYG11B -0.56 -11.53 -0.42 4.35e-28 Monocyte count; BRCA cis rs6860806 0.507 rs274572 chr5:131710917 T/G cg07395648 chr5:131743802 NA 0.38 8.23 0.31 1.02e-15 Breast cancer; BRCA cis rs12762955 0.561 rs11253567 chr10:1054444 A/G cg26597838 chr10:835615 NA 0.52 9.16 0.34 6.78e-19 Response to angiotensin II receptor blocker therapy; BRCA cis rs2243480 1.000 rs2420170 chr7:65656053 T/C cg18252515 chr7:66147081 NA 1.06 16.03 0.54 7.81e-49 Diabetic kidney disease; BRCA cis rs858239 0.698 rs858295 chr7:23245569 A/G cg23682824 chr7:23144976 KLHL7 0.31 7.96 0.3 7.66e-15 Cerebrospinal fluid biomarker levels; BRCA cis rs644799 0.601 rs662168 chr11:95586982 C/T cg25622487 chr11:95524042 FAM76B;CEP57 0.63 15.9 0.53 3.34e-48 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs12142240 0.659 rs111723629 chr1:46853361 G/T cg14993813 chr1:46806288 NSUN4 -0.49 -9.61 -0.36 1.69e-20 Menopause (age at onset); BRCA cis rs1707322 0.717 rs2275086 chr1:46085879 C/G cg03146154 chr1:46216737 IPP -0.5 -11.22 -0.41 8.47e-27 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2075371 0.501 rs1643051 chr7:134025372 A/G cg02659138 chr7:134003124 SLC35B4 -0.29 -8.83 -0.33 1e-17 Mean platelet volume; BRCA cis rs7617773 0.817 rs13094727 chr3:48323489 G/A cg11946769 chr3:48343235 NME6 0.67 13.65 0.48 2.04e-37 Coronary artery disease; BRCA cis rs2016266 0.896 rs3741663 chr12:53664015 G/A cg26875137 chr12:53738046 NA 0.35 9.54 0.35 2.94e-20 Bone mineral density (spine);Bone mineral density; BRCA cis rs798554 0.610 rs2251491 chr7:2852835 T/C cg19717773 chr7:2847554 GNA12 -0.43 -9.79 -0.36 3.4e-21 Height; BRCA cis rs763121 0.813 rs4821807 chr22:39065582 A/G cg06544989 chr22:39130855 UNC84B 0.37 9.13 0.34 8.96e-19 Menopause (age at onset); BRCA cis rs9291683 0.530 rs10939620 chr4:9946132 C/T cg11266682 chr4:10021025 SLC2A9 -0.42 -11.3 -0.41 3.86e-27 Bone mineral density; BRCA cis rs10751667 0.666 rs7396473 chr11:966181 T/C cg10932868 chr11:921992 NA 0.49 12.38 0.44 1.09e-31 Alzheimer's disease (late onset); BRCA cis rs7662987 0.517 rs2851277 chr4:100022910 G/T cg13256891 chr4:100009986 ADH5 0.54 9.98 0.37 7.03e-22 Smoking initiation; BRCA cis rs7772486 0.790 rs2265919 chr6:146221753 A/G cg05347473 chr6:146136440 FBXO30 0.41 8.06 0.3 3.74e-15 Lobe attachment (rater-scored or self-reported); BRCA trans rs3857536 0.740 rs7745163 chr6:66889936 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.48 -9.67 -0.36 1.01e-20 Blood trace element (Cu levels); BRCA cis rs7100689 0.577 rs9420349 chr10:82031160 T/C cg01528321 chr10:82214614 TSPAN14 0.72 16.16 0.54 1.66e-49 Post bronchodilator FEV1; BRCA trans rs2204008 0.818 rs1589389 chr12:38416041 G/A cg06521331 chr12:34319734 NA 0.47 9.3 0.35 2.26e-19 Bladder cancer; BRCA cis rs7258465 1.000 rs2007981 chr19:18567555 C/A cg01065977 chr19:18549689 ISYNA1 -0.29 -8.78 -0.33 1.46e-17 Breast cancer; BRCA cis rs2066819 1.000 rs17118403 chr12:56630067 C/T cg26734620 chr12:56694298 CS 0.86 9.88 0.36 1.64e-21 Psoriasis vulgaris; BRCA cis rs12950390 0.853 rs56363619 chr17:45854621 T/C cg03474202 chr17:45855739 NA -0.47 -12.55 -0.44 1.8e-32 IgG glycosylation; BRCA cis rs7945705 0.967 rs10769968 chr11:8907583 G/C cg21881798 chr11:8931708 C11orf17;ST5 0.59 12.98 0.46 2.31e-34 Hemoglobin concentration; BRCA cis rs933688 1.000 rs10474353 chr5:90732285 A/C cg12630606 chr5:90679528 LOC100129716;ARRDC3 0.97 21.93 0.66 6.99e-80 Smoking behavior; BRCA cis rs514406 0.929 rs1672909 chr1:53340824 A/G cg16325326 chr1:53192061 ZYG11B 0.71 17.04 0.56 5.67e-54 Monocyte count; BRCA cis rs2505998 1.000 rs2435357 chr10:43582056 T/C cg15436174 chr10:43711423 RASGEF1A -0.41 -7.94 -0.3 9.29e-15 Hirschsprung disease; BRCA cis rs2153535 0.580 rs1119690 chr6:8460660 G/A cg23788917 chr6:8435910 SLC35B3 0.48 10.44 0.38 1.12e-23 Motion sickness; BRCA cis rs78456975 0.527 rs72778003 chr2:1571487 G/A cg12573674 chr2:1569213 NA -0.61 -13.42 -0.47 2.46e-36 Placebo response in major depressive disorder (% change in symptom score); BRCA trans rs9354352 0.818 rs9453548 chr6:66691885 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.55 -12.2 -0.43 6.38e-31 Initial pursuit acceleration in psychotic disorders; BRCA cis rs3771570 1.000 rs62186400 chr2:242226700 A/G cg21155796 chr2:242212141 HDLBP 0.6 9.49 0.35 4.51e-20 Prostate cancer; BRCA cis rs2836974 0.666 rs4818015 chr21:40675493 A/C cg22974920 chr21:40686053 BRWD1 0.4 9.03 0.34 1.99e-18 Cognitive function; BRCA cis rs2032447 0.933 rs1540275 chr6:26036476 T/C cg03264133 chr6:25882463 NA -0.54 -11.46 -0.41 8.77e-28 Intelligence (multi-trait analysis); BRCA cis rs7677751 0.767 rs6554158 chr4:55066077 G/A cg17187183 chr4:55093834 PDGFRA 0.4 8.2 0.31 1.34e-15 Corneal astigmatism; BRCA trans rs208520 0.690 rs12202805 chr6:66703903 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.95 -20.07 -0.62 7.65e-70 Exhaled nitric oxide output; BRCA trans rs7178375 0.941 rs4779796 chr15:31208050 C/T cg04373760 chr16:53404718 NA 0.47 8.85 0.33 8.41e-18 Hypertriglyceridemia; BRCA cis rs7412746 0.611 rs10788794 chr1:150728676 T/C cg15448220 chr1:150897856 SETDB1 0.37 8.25 0.31 8.72e-16 Melanoma; BRCA cis rs7131987 0.903 rs918873 chr12:29390501 G/T cg09582351 chr12:29534625 ERGIC2 -0.41 -9.62 -0.36 1.51e-20 QT interval; BRCA cis rs3772130 0.962 rs9848027 chr3:121551227 T/C cg01951420 chr3:121553821 IQCB1;EAF2 0.57 10.64 0.39 1.94e-24 Cognitive performance; BRCA cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg02187348 chr16:89574699 SPG7 0.46 11.03 0.4 5.04e-26 Multiple myeloma (IgH translocation); BRCA trans rs2727020 0.521 rs7131163 chr11:49574774 C/T cg03929089 chr4:120376271 NA -0.66 -12.93 -0.46 3.9e-34 Coronary artery disease; BRCA cis rs3096299 0.692 rs4785565 chr16:89515759 T/C cg08392591 chr16:89556376 ANKRD11 0.52 12.66 0.45 6.47e-33 Multiple myeloma (IgH translocation); BRCA cis rs798554 1.000 rs798544 chr7:2763102 A/G cg21143896 chr7:2802374 GNA12 0.34 8.52 0.32 1.11e-16 Height; BRCA cis rs921968 0.565 rs6436086 chr2:219640125 T/C cg02176678 chr2:219576539 TTLL4 -0.41 -11.04 -0.4 4.9e-26 Mean corpuscular hemoglobin concentration; BRCA trans rs75804782 0.630 rs79693451 chr2:239296473 A/G cg01134436 chr17:81009848 B3GNTL1 0.76 7.94 0.3 9.25e-15 Morning vs. evening chronotype;Chronotype; BRCA cis rs344364 0.511 rs12596510 chr16:1949480 G/A cg09830162 chr16:1889614 FAHD1;C16orf73 -0.55 -9.74 -0.36 5.28e-21 Glomerular filtration rate in chronic kidney disease; BRCA cis rs8114671 0.562 rs6087653 chr20:33522054 T/C cg07148914 chr20:33460835 GGT7 0.38 8.62 0.32 5.15e-17 Height; BRCA cis rs116095464 0.558 rs56081398 chr5:247318 C/T cg22857025 chr5:266934 NA -1.04 -19.98 -0.62 2.21e-69 Breast cancer; BRCA cis rs3760982 0.585 rs8109478 chr19:44298256 C/T cg12072164 chr19:44306565 LYPD5 0.36 8.7 0.33 2.75e-17 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs2011503 0.943 rs1529745 chr19:19517325 C/G cg11584989 chr19:19387371 SF4 0.62 13.31 0.47 7.53e-36 Bipolar disorder; BRCA cis rs7246657 0.943 rs7255407 chr19:37933936 G/A cg18154014 chr19:37997991 ZNF793 0.48 9.41 0.35 8.49e-20 Coronary artery calcification; BRCA cis rs11105298 0.891 rs10858881 chr12:89891474 T/G cg08166232 chr12:89918718 WDR51B;GALNT4 -0.58 -9.72 -0.36 6.22e-21 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7772486 0.790 rs2243665 chr6:146208120 A/C cg13319975 chr6:146136371 FBXO30 -0.4 -8.69 -0.33 3.01e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.953 rs2270610 chr8:58194669 A/G cg24829409 chr8:58192753 C8orf71 -0.58 -11.76 -0.42 4.84e-29 Developmental language disorder (linguistic errors); BRCA trans rs11098499 0.535 rs10005542 chr4:120268302 T/C cg25214090 chr10:38739885 LOC399744 0.43 10.0 0.37 5.45e-22 Corneal astigmatism; BRCA cis rs7666738 0.606 rs28625338 chr4:99076996 A/G cg05340658 chr4:99064831 C4orf37 0.49 10.73 0.39 8.14e-25 Colonoscopy-negative controls vs population controls; BRCA cis rs6878727 0.815 rs9885338 chr5:123725320 G/A cg01806427 chr5:123737813 NA 0.42 9.58 0.35 2.09e-20 Breast cancer; BRCA cis rs6952808 0.656 rs12699646 chr7:2093162 T/G cg00106254 chr7:1943704 MAD1L1 0.39 10.12 0.37 2.04e-22 Bipolar disorder and schizophrenia; BRCA cis rs17209837 0.607 rs10452936 chr7:87094306 C/A cg00919237 chr7:87102261 ABCB4 -0.53 -10.2 -0.37 9.44e-23 Gallbladder cancer; BRCA cis rs1046896 1.000 rs1046917 chr17:80685655 A/G cg02711726 chr17:80685570 FN3KRP 0.68 16.5 0.55 3.31e-51 Glycated hemoglobin levels; BRCA cis rs6500602 0.929 rs9926114 chr16:4478322 C/G cg08645402 chr16:4508243 NA 0.37 8.64 0.32 4.52e-17 Schizophrenia; BRCA cis rs6088590 0.523 rs6059913 chr20:33143288 G/A cg24642439 chr20:33292090 TP53INP2 0.57 12.48 0.44 3.99e-32 Coronary artery disease; BRCA cis rs7666738 0.785 rs11097614 chr4:99092175 G/C cg05340658 chr4:99064831 C4orf37 0.51 9.75 0.36 5.14e-21 Colonoscopy-negative controls vs population controls; BRCA cis rs56235845 0.694 rs36102285 chr5:176774018 C/T cg17509989 chr5:176798049 RGS14 0.67 13.13 0.46 5.08e-35 Hemoglobin concentration;Hematocrit; BRCA cis rs2777491 0.574 rs11635906 chr15:41779260 A/G cg18705301 chr15:41695430 NDUFAF1 -1.05 -25.06 -0.7 4.72e-97 Ulcerative colitis; BRCA cis rs2522056 1.000 rs7730247 chr5:131781288 A/C cg24060327 chr5:131705240 SLC22A5 0.44 7.82 0.3 2.26e-14 Lymphocyte counts;Fibrinogen; BRCA trans rs208520 1.000 rs208537 chr6:66963544 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.85 -14.55 -0.5 1.24e-41 Exhaled nitric oxide output; BRCA cis rs6582630 0.555 rs11613249 chr12:38519339 T/C cg26384229 chr12:38710491 ALG10B 0.74 17.65 0.57 4.53e-57 Drug-induced liver injury (flucloxacillin); BRCA cis rs4713118 0.955 rs34752872 chr6:27683244 A/T cg20933634 chr6:27740509 NA 0.43 8.42 0.32 2.57e-16 Parkinson's disease; BRCA cis rs870825 0.616 rs28666955 chr4:185631338 A/G cg04058563 chr4:185651563 MLF1IP 0.77 17.14 0.56 1.9e-54 Blood protein levels; BRCA cis rs1691799 0.899 rs1168351 chr12:66752505 A/G cg16791601 chr12:66731901 HELB -0.67 -18.63 -0.59 3.23e-62 White blood cell count (basophil); BRCA cis rs12618769 0.652 rs3769698 chr2:99233894 T/C cg10123293 chr2:99228465 UNC50 0.42 8.41 0.32 2.65e-16 Bipolar disorder; BRCA trans rs10506458 1.000 rs12425932 chr12:63410497 C/A cg03429785 chr15:59498649 MYO1E;LDHAL6B -1.13 -18.74 -0.6 8.96e-63 Hemostatic factors and hematological phenotypes; BRCA cis rs9325144 0.560 rs11183150 chr12:38674698 A/G cg13010199 chr12:38710504 ALG10B -0.38 -8.74 -0.33 2e-17 Morning vs. evening chronotype; BRCA cis rs769267 0.930 rs3794993 chr19:19611550 G/T cg01262667 chr19:19385393 TM6SF2 0.4 10.49 0.38 7.35e-24 Tonsillectomy; BRCA cis rs9325144 0.555 rs7977200 chr12:38713745 C/T cg13010199 chr12:38710504 ALG10B 0.35 8.02 0.3 4.98e-15 Morning vs. evening chronotype; BRCA cis rs6951245 0.580 rs78894484 chr7:1138721 T/G cg26224354 chr7:1096374 C7orf50;GPR146 -0.66 -12.91 -0.45 4.93e-34 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs208520 0.526 rs4710310 chr6:66802808 T/C cg07460842 chr6:66804631 NA -1.13 -35.7 -0.82 2.49e-154 Exhaled nitric oxide output; BRCA cis rs875971 1.000 rs7792762 chr7:66004138 T/C cg12463550 chr7:65579703 CRCP 0.37 7.87 0.3 1.56e-14 Aortic root size; BRCA cis rs172166 0.694 rs9295760 chr6:28147385 G/A cg02631126 chr6:28058918 ZSCAN12L1 0.26 8.14 0.31 2.05e-15 Cardiac Troponin-T levels; BRCA cis rs8022179 0.580 rs6575979 chr14:103841018 A/G cg12935359 chr14:103987150 CKB -0.47 -9.43 -0.35 7.15e-20 Monocyte count; BRCA cis rs7312933 0.933 rs4534650 chr12:42444222 A/G cg17420585 chr12:42539391 GXYLT1 -0.49 -10.61 -0.39 2.54e-24 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs780096 0.546 rs1060525 chr2:27635582 A/G cg24768116 chr2:27665128 KRTCAP3 -0.32 -7.98 -0.3 6.81e-15 Total body bone mineral density; BRCA cis rs2836974 0.739 rs12482181 chr21:40548852 A/G cg11644478 chr21:40555479 PSMG1 0.83 19.15 0.6 6.37e-65 Cognitive function; BRCA cis rs1568889 1.000 rs33937991 chr11:28045260 A/G cg06544937 chr11:28130018 METT5D1;KIF18A 0.66 14.66 0.5 3.59e-42 Bipolar disorder; BRCA cis rs60871478 1.000 rs62432899 chr7:826542 G/C cg05729249 chr7:766119 PRKAR1B;HEATR2 0.53 7.89 0.3 1.31e-14 Cerebrospinal P-tau181p levels; BRCA cis rs701145 0.585 rs62276841 chr3:153783645 C/T cg17054900 chr3:154042577 DHX36 -0.53 -9.19 -0.34 5.48e-19 Coronary artery disease; BRCA cis rs832540 0.695 rs702686 chr5:56201350 A/G cg18230493 chr5:56204884 C5orf35 -0.57 -12.26 -0.44 3.37e-31 Coronary artery disease; BRCA cis rs12711979 0.765 rs7559461 chr2:3818623 G/A cg17052675 chr2:3827356 NA -0.48 -14.1 -0.49 1.76e-39 Itch intensity from mosquito bite adjusted by bite size; BRCA trans rs12517041 1.000 rs1428624 chr5:23290393 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.45 -8.13 -0.31 2.16e-15 Calcium levels; BRCA cis rs9443645 0.527 rs9350792 chr6:79587173 A/G cg09184832 chr6:79620586 NA -0.41 -8.25 -0.31 9.35e-16 Intelligence (multi-trait analysis); BRCA cis rs490234 0.552 rs2841327 chr9:128156503 G/A cg14078157 chr9:128172775 NA -0.43 -10.23 -0.38 7.21e-23 Mean arterial pressure; BRCA cis rs763014 0.966 rs12935215 chr16:670605 T/C cg00802000 chr16:706648 WDR90 -0.41 -9.65 -0.36 1.16e-20 Height; BRCA cis rs875971 0.660 rs3857686 chr7:66036191 C/T cg11764359 chr7:65958608 NA -0.68 -15.39 -0.52 1.07e-45 Aortic root size; BRCA cis rs7646881 0.812 rs59957986 chr3:158458913 G/A cg19483011 chr3:158453295 NA -0.45 -7.97 -0.3 7.58e-15 Tetralogy of Fallot; BRCA cis rs495337 1.000 rs1056198 chr20:48556229 C/T cg17835207 chr20:48524531 SPATA2 -0.58 -13.13 -0.46 5e-35 Psoriasis; BRCA cis rs60871478 1.000 rs35488064 chr7:812722 G/C cg04727924 chr7:799746 HEATR2 -0.55 -10.72 -0.39 9.37e-25 Cerebrospinal P-tau181p levels; BRCA cis rs2070488 0.965 rs1058945 chr3:38532511 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.72 -19.81 -0.62 1.94e-68 Electrocardiographic conduction measures; BRCA cis rs2624839 0.704 rs13067082 chr3:50221715 A/G cg14019146 chr3:50243930 SLC38A3 0.64 15.96 0.53 1.67e-48 Intelligence (multi-trait analysis); BRCA cis rs78456975 1.000 rs6720874 chr2:1580504 A/G cg26248373 chr2:1572462 NA -0.51 -10.19 -0.37 1.11e-22 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs6684514 1.000 rs67034206 chr1:156270260 C/T cg16558208 chr1:156270281 VHLL 0.36 8.43 0.32 2.35e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs6088580 0.634 rs6142159 chr20:32993035 G/A cg06115741 chr20:33292138 TP53INP2 -0.37 -8.15 -0.31 1.89e-15 Glomerular filtration rate (creatinine); BRCA cis rs929596 0.556 rs10168416 chr2:234597087 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.39 -9.57 -0.35 2.29e-20 Total bilirubin levels in HIV-1 infection; BRCA cis rs11971779 0.650 rs10085842 chr7:139064582 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.21 0.37 9.03e-23 Diisocyanate-induced asthma; BRCA cis rs1577917 1.000 rs2816815 chr6:86691656 C/T cg17490806 chr6:86388072 SNHG5;SNORD50B;SNORD50A -0.41 -11.23 -0.41 7.63e-27 Response to antipsychotic treatment; BRCA cis rs1008375 0.800 rs10008598 chr4:17607323 T/C cg15017067 chr4:17643749 FAM184B 0.29 8.85 0.33 8.48e-18 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs9443645 0.901 rs9359354 chr6:79590385 A/G cg11833968 chr6:79620685 NA -0.44 -9.81 -0.36 2.92e-21 Intelligence (multi-trait analysis); BRCA cis rs3820928 0.692 rs2396434 chr2:227775223 G/T cg11843606 chr2:227700838 RHBDD1 -0.51 -11.85 -0.42 1.96e-29 Pulmonary function; BRCA cis rs7809950 1.000 rs3801944 chr7:107255548 T/C cg23024343 chr7:107201750 COG5 0.36 8.24 0.31 1e-15 Coronary artery disease; BRCA cis rs10193935 0.901 rs7594010 chr2:42534896 C/T cg27598129 chr2:42591480 NA -0.95 -14.79 -0.5 8.83e-43 Colonoscopy-negative controls vs population controls; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.37 0.41 2.13e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4363385 0.818 rs4845514 chr1:153000820 T/C cg25856811 chr1:152973957 SPRR3 -0.32 -8.4 -0.32 2.84e-16 Inflammatory skin disease; BRCA cis rs2404602 0.647 rs1443115 chr15:77041829 T/C cg23625390 chr15:77176239 SCAPER -0.55 -12.82 -0.45 1.24e-33 Blood metabolite levels; BRCA cis rs7589728 0.620 rs76687350 chr2:88473832 G/A cg07952391 chr2:88470173 THNSL2 0.64 8.61 0.32 5.56e-17 Plasma clusterin levels; BRCA cis rs7408868 1.000 rs10418305 chr19:15278808 C/G cg14696996 chr19:15285081 NOTCH3 1.0 14.52 0.5 1.76e-41 Pulse pressure; BRCA cis rs7666738 0.830 rs7669407 chr4:98750251 G/A cg17366294 chr4:99064904 C4orf37 0.41 9.64 0.36 1.23e-20 Colonoscopy-negative controls vs population controls; BRCA cis rs11098499 0.866 rs12374352 chr4:120281977 C/T cg09307838 chr4:120376055 NA 0.66 14.21 0.49 4.94e-40 Corneal astigmatism; BRCA cis rs9443645 0.901 rs9343860 chr6:79739010 G/A cg09184832 chr6:79620586 NA -0.54 -11.94 -0.43 8.48e-30 Intelligence (multi-trait analysis); BRCA cis rs701145 0.585 rs1727884 chr3:153838368 A/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs736801 0.607 rs11739135 chr5:131733397 C/G cg14196790 chr5:131705035 SLC22A5 0.44 10.69 0.39 1.18e-24 Breast cancer;Mosquito bite size; BRCA cis rs10752881 1.000 rs12035773 chr1:182985716 A/G ch.1.3577855R chr1:183094577 LAMC1 0.63 16.64 0.55 6.17e-52 Colorectal cancer; BRCA cis rs7618915 0.501 rs6617 chr3:52740182 C/G cg18404041 chr3:52824283 ITIH1 -0.38 -11.76 -0.42 4.7e-29 Bipolar disorder; BRCA trans rs9467711 0.606 rs2393667 chr6:26421345 T/C cg01620082 chr3:125678407 NA -0.63 -8.39 -0.32 3.12e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs6500602 0.627 rs11639998 chr16:4527109 T/C cg14951292 chr16:4525986 HMOX2;NMRAL1 0.43 9.02 0.34 2.15e-18 Schizophrenia; BRCA cis rs2075371 1.000 rs1862050 chr7:133980999 T/C cg11752832 chr7:134001865 SLC35B4 0.53 13.8 0.48 4.03e-38 Mean platelet volume; BRCA cis rs17818399 0.510 rs1451153 chr2:46799852 G/T cg02822958 chr2:46747628 ATP6V1E2 0.53 11.12 0.4 2.27e-26 Height; BRCA cis rs270601 0.710 rs4705852 chr5:131602807 A/G cg18301423 chr5:131593218 PDLIM4 0.35 8.75 0.33 1.93e-17 Acylcarnitine levels; BRCA cis rs12431939 1.000 rs67113863 chr14:51653103 G/C cg23942311 chr14:51606299 NA -0.44 -8.2 -0.31 1.36e-15 Cancer; BRCA cis rs9381040 0.655 rs6903444 chr6:41014220 C/T cg03644281 chr6:41068752 NFYA;LOC221442 0.41 8.79 0.33 1.33e-17 Alzheimer's disease (late onset); BRCA cis rs7249142 0.549 rs62135499 chr19:19294237 T/C cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.5 -11.16 -0.4 1.58e-26 IgG glycosylation; BRCA cis rs6964587 0.967 rs12535601 chr7:91718346 A/G cg17063962 chr7:91808500 NA 0.52 12.42 0.44 6.92e-32 Breast cancer; BRCA cis rs2742234 0.590 rs2503863 chr10:43667398 G/A cg15436174 chr10:43711423 RASGEF1A -0.55 -11.04 -0.4 4.86e-26 Hirschsprung disease; BRCA cis rs796364 0.806 rs11684942 chr2:201009136 C/T cg25936922 chr2:200820526 C2orf60;C2orf47 -0.68 -10.14 -0.37 1.7e-22 Schizophrenia; BRCA cis rs4595586 0.505 rs11611321 chr12:39390803 C/T cg26384229 chr12:38710491 ALG10B 0.42 9.45 0.35 6.27e-20 Morning vs. evening chronotype; BRCA cis rs11874712 1.000 rs8089150 chr18:43674300 A/G cg20479805 chr18:43684716 ATP5A1;HAUS1 0.34 8.05 0.3 4.16e-15 Migraine - clinic-based; BRCA cis rs6089584 0.566 rs6061964 chr20:60607536 G/A cg06108461 chr20:60628389 TAF4 -0.71 -14.9 -0.51 2.59e-43 Body mass index; BRCA cis rs7666738 0.830 rs7679961 chr4:99000202 C/T cg03676636 chr4:99064102 C4orf37 0.2 7.9 0.3 1.2e-14 Colonoscopy-negative controls vs population controls; BRCA cis rs1904096 0.506 rs13434570 chr4:95168019 T/C cg11021082 chr4:95130006 SMARCAD1 -0.44 -10.2 -0.37 9.63e-23 Type 2 diabetes; BRCA cis rs17023223 0.537 rs10923767 chr1:119732347 C/T cg05756136 chr1:119680316 WARS2 -0.42 -8.16 -0.31 1.72e-15 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for BMI in active individuals; BRCA cis rs4722166 0.695 rs7808122 chr7:22798080 A/G cg05472934 chr7:22766657 IL6 0.48 12.45 0.44 5.29e-32 Lung cancer; BRCA cis rs6960043 0.818 rs10238625 chr7:15054232 A/G cg19272540 chr7:15055459 NA 0.22 8.02 0.3 4.93e-15 Type 2 diabetes; BRCA cis rs2991971 1.000 rs2991972 chr1:46013208 C/T cg15605315 chr1:45957053 TESK2 0.46 9.38 0.35 1.18e-19 High light scatter reticulocyte count; BRCA cis rs1691799 0.899 rs1177555 chr12:66727568 A/G cg16791601 chr12:66731901 HELB -0.65 -17.46 -0.57 4.37e-56 White blood cell count (basophil); BRCA cis rs870825 0.616 rs4519834 chr4:185633865 A/G cg04058563 chr4:185651563 MLF1IP -0.79 -18.1 -0.58 2.04e-59 Blood protein levels; BRCA trans rs11098499 0.863 rs11723090 chr4:120490592 T/C cg25214090 chr10:38739885 LOC399744 0.54 11.83 0.42 2.49e-29 Corneal astigmatism; BRCA cis rs12142240 0.698 rs1135459 chr1:46815930 C/T cg00530320 chr1:46809349 NSUN4 0.48 9.66 0.36 1.1e-20 Menopause (age at onset); BRCA cis rs12681288 0.676 rs2701914 chr8:999935 C/T cg04851639 chr8:1020857 NA -0.39 -11.21 -0.41 9.63e-27 Schizophrenia; BRCA cis rs2070488 0.804 rs13063978 chr3:38476538 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B 0.66 17.72 0.57 1.83e-57 Electrocardiographic conduction measures; BRCA cis rs6717918 0.620 rs7570112 chr2:233150452 A/G ch.2.233013039R chr2:233304795 NA 0.45 9.39 0.35 1.02e-19 Height; BRCA cis rs698833 1.000 rs698833 chr2:44735438 A/G cg18685995 chr2:44588913 PREPL;C2orf34 0.49 9.54 0.35 3.07e-20 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs1008375 0.897 rs3733577 chr4:17649233 T/G cg04450456 chr4:17643702 FAM184B 0.37 11.01 0.4 6.09e-26 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs79387448 0.638 rs116055209 chr2:103032189 C/T cg09003973 chr2:102972529 NA 0.59 8.8 0.33 1.22e-17 Gut microbiota (bacterial taxa); BRCA cis rs651907 0.535 rs11712309 chr3:101519097 T/C cg03837452 chr3:101395095 ZBTB11;LOC100009676 0.52 13.49 0.47 1.16e-36 Colorectal cancer; BRCA cis rs4665809 0.590 rs4665321 chr2:26433801 A/C cg08067268 chr2:26466485 HADHB;HADHA -0.57 -9.79 -0.36 3.54e-21 Gut microbiome composition (summer); BRCA cis rs2180341 0.924 rs877661 chr6:127587915 T/G cg24812749 chr6:127587940 RNF146 0.87 19.64 0.61 1.51e-67 Breast cancer; BRCA cis rs559928 0.606 rs60394481 chr11:63909035 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.84 11.12 0.4 2.27e-26 Inflammatory bowel disease;Crohn's disease;Ulcerative colitis; BRCA cis rs13191362 1.000 rs35092540 chr6:163090778 A/G cg18825119 chr6:163149453 PACRG;PARK2 0.53 8.05 0.3 4.13e-15 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9837602 0.507 rs6803204 chr3:99680874 G/A cg21419939 chr3:99598918 C3orf26;FILIP1L;MIR548G -0.39 -7.85 -0.3 1.77e-14 Breast cancer; BRCA cis rs11098499 0.863 rs11947234 chr4:120474859 A/G cg09307838 chr4:120376055 NA 0.69 14.08 0.49 2.13e-39 Corneal astigmatism; BRCA cis rs9733 0.650 rs1971378 chr1:150597261 C/T cg18016565 chr1:150552671 MCL1 -0.44 -9.76 -0.36 4.62e-21 Tonsillectomy; BRCA trans rs6952808 0.792 rs13224989 chr7:1953766 C/G cg04565464 chr8:145669602 NFKBIL2 0.38 8.77 0.33 1.61e-17 Bipolar disorder and schizophrenia; BRCA cis rs769267 0.930 rs10422819 chr19:19643028 C/A cg03709012 chr19:19516395 GATAD2A 0.8 18.47 0.59 2.3e-61 Tonsillectomy; BRCA cis rs17376456 0.877 rs12109629 chr5:93359702 A/G cg25358565 chr5:93447407 FAM172A 1.14 18.59 0.59 5.23e-62 Diabetic retinopathy; BRCA cis rs7714584 1.000 rs11957134 chr5:150230950 A/G cg22134413 chr5:150180641 NA -0.67 -10.35 -0.38 2.66e-23 Crohn's disease; BRCA cis rs887829 0.507 rs10929301 chr2:234663649 C/G cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.3 -7.89 -0.3 1.3e-14 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA cis rs6066825 0.644 rs6095248 chr20:47320932 A/G cg18078177 chr20:47281410 PREX1 0.41 10.1 0.37 2.46e-22 Colorectal cancer; BRCA cis rs760805 1.000 rs61774728 chr1:25258867 G/C cg22509179 chr1:25234806 RUNX3 -0.57 -14.68 -0.5 2.96e-42 Allergic disease (asthma, hay fever or eczema); BRCA cis rs2011503 0.739 rs4808973 chr19:19725456 A/G cg15839431 chr19:19639596 YJEFN3 0.35 7.99 0.3 6.13e-15 Bipolar disorder; BRCA cis rs9308433 0.529 rs867444 chr1:214502160 T/C cg06198575 chr1:214491504 SMYD2 0.53 11.62 0.42 1.94e-28 IgG glycosylation; BRCA trans rs6089829 0.851 rs4809460 chr20:61661355 T/C cg15934090 chr1:100435551 SLC35A3 0.36 8.38 0.31 3.28e-16 Prostate cancer (SNP x SNP interaction); BRCA cis rs1862618 0.802 rs832560 chr5:56124423 T/A cg20203395 chr5:56204925 C5orf35 -0.5 -10.64 -0.39 1.83e-24 Initial pursuit acceleration; BRCA cis rs68170813 0.559 rs4730232 chr7:106942382 G/C cg02696742 chr7:106810147 HBP1 -0.53 -8.55 -0.32 9.34e-17 Coronary artery disease; BRCA cis rs2832191 0.716 rs1543652 chr21:30448000 G/C cg08807101 chr21:30365312 RNF160 0.74 18.87 0.6 1.91e-63 Dental caries; BRCA cis rs13191362 1.000 rs73035023 chr6:163000927 C/T cg14584255 chr6:163149320 PACRG;PARK2 0.49 8.28 0.31 7.49e-16 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs1707322 0.717 rs1547925 chr1:46085356 C/T cg03146154 chr1:46216737 IPP -0.49 -10.8 -0.39 4.37e-25 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs35110281 0.687 rs4819284 chr21:45084548 C/T cg21573476 chr21:45109991 RRP1B -0.35 -9.5 -0.35 4.07e-20 Mean corpuscular volume; BRCA cis rs9790314 0.582 rs13071909 chr3:160604864 A/G cg03342759 chr3:160939853 NMD3 0.43 8.29 0.31 6.73e-16 Morning vs. evening chronotype; BRCA cis rs3820928 0.874 rs4144328 chr2:227790187 A/C cg05526886 chr2:227700861 RHBDD1 -0.38 -7.89 -0.3 1.36e-14 Pulmonary function; BRCA cis rs17401966 0.627 rs35859381 chr1:10466040 G/A cg19773385 chr1:10388646 KIF1B -0.37 -7.95 -0.3 8.73e-15 Hepatocellular carcinoma; BRCA cis rs11168351 1.000 rs11168351 chr12:48403765 C/T cg24011408 chr12:48396354 COL2A1 0.42 8.26 0.31 8.12e-16 Bipolar disorder and schizophrenia; BRCA cis rs10782582 0.593 rs74090712 chr1:76189098 A/G cg03433033 chr1:76189801 ACADM -0.5 -10.5 -0.38 6.58e-24 Daytime sleep phenotypes; BRCA cis rs6570726 0.791 rs440477 chr6:145854188 C/T cg05347473 chr6:146136440 FBXO30 0.42 8.45 0.32 2.03e-16 Lobe attachment (rater-scored or self-reported); BRCA cis rs10504229 0.861 rs57942497 chr8:58171239 G/T cg24829409 chr8:58192753 C8orf71 -0.61 -12.6 -0.45 1.13e-32 Developmental language disorder (linguistic errors); BRCA cis rs769267 0.930 rs1054930 chr19:19648346 G/C cg26732615 chr19:19648335 CILP2;YJEFN3 0.38 8.28 0.31 7.36e-16 Tonsillectomy; BRCA cis rs5167 0.504 rs892101 chr19:45455458 G/A cg10169327 chr19:45448959 APOC2 0.31 7.94 0.3 9.02e-15 Blood protein levels; BRCA trans rs6479891 1.000 rs4746119 chr10:65129917 T/C cg14819942 chr15:35414228 NA 0.35 8.6 0.32 6e-17 Arthritis (juvenile idiopathic); BRCA cis rs6951245 0.872 rs112309216 chr7:1100296 A/T cg04025307 chr7:1156635 C7orf50 0.58 9.08 0.34 1.34e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs11764590 0.671 rs56226325 chr7:2078981 C/T cg02743256 chr7:2109353 MAD1L1 -0.46 -8.12 -0.31 2.36e-15 Neuroticism; BRCA cis rs3096299 0.685 rs4238830 chr16:89540241 C/T cg08392591 chr16:89556376 ANKRD11 0.53 13.02 0.46 1.54e-34 Multiple myeloma (IgH translocation); BRCA cis rs8177253 1.000 rs8177261 chr3:133480588 A/C cg01448562 chr3:133502909 NA -0.61 -14.38 -0.49 7.95e-41 Iron status biomarkers; BRCA cis rs6001027 0.517 rs2284060 chr22:38543453 A/G cg25457927 chr22:38595422 NA -0.27 -9.73 -0.36 6.12e-21 Melanoma; BRCA cis rs10479542 0.784 rs4701132 chr5:178985270 A/G cg19626725 chr5:178986131 RUFY1 -0.35 -10.89 -0.4 1.89e-25 Lung cancer; BRCA cis rs2228479 0.764 rs7191836 chr16:89961597 T/C cg06558623 chr16:89946397 TCF25 0.65 11.86 0.42 1.8e-29 Skin colour saturation; BRCA cis rs3793683 0.928 rs10781585 chr10:134553369 C/A cg27286337 chr10:134555280 INPP5A -0.85 -21.57 -0.65 6.32e-78 Migraine; BRCA cis rs2153535 0.580 rs1932275 chr6:8442333 T/A cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.23e-24 Motion sickness; BRCA cis rs4595586 0.545 rs6580895 chr12:39372011 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.34 -0.35 1.55e-19 Morning vs. evening chronotype; BRCA cis rs919433 0.679 rs10931788 chr2:198531084 A/G cg00792783 chr2:198669748 PLCL1 0.39 9.01 0.34 2.27e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10876993 0.806 rs1689598 chr12:58050500 G/C cg00677455 chr12:58241039 CTDSP2 -0.35 -7.84 -0.3 1.95e-14 Celiac disease or Rheumatoid arthritis; BRCA cis rs9837602 0.935 rs9875640 chr3:99729091 C/T cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.56 0.39 4.06e-24 Breast cancer; BRCA trans rs61931739 0.517 rs11053067 chr12:34191391 T/C cg26384229 chr12:38710491 ALG10B 0.68 14.54 0.5 1.35e-41 Morning vs. evening chronotype; BRCA cis rs7666738 0.830 rs4699577 chr4:98846513 G/A cg17366294 chr4:99064904 C4orf37 0.43 9.98 0.37 6.6e-22 Colonoscopy-negative controls vs population controls; BRCA cis rs3741404 0.825 rs2845597 chr11:63954370 G/A cg19465662 chr11:63993652 NUDT22;TRPT1 0.82 19.59 0.61 2.64e-67 Platelet count; BRCA cis rs9837602 0.938 rs9815439 chr3:99785206 G/C cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 10.52 0.38 5.73e-24 Breast cancer; BRCA cis rs7727544 0.661 rs273900 chr5:131694606 G/A cg07395648 chr5:131743802 NA -0.37 -9.18 -0.34 5.75e-19 Blood metabolite levels; BRCA cis rs367943 0.637 rs6891711 chr5:113009026 G/T cg12552261 chr5:112820674 MCC -0.39 -8.32 -0.31 5.19e-16 Type 2 diabetes; BRCA cis rs10540 1.000 rs79808876 chr11:465763 C/A cg03576123 chr11:487126 PTDSS2 -1.2 -18.77 -0.6 6.11e-63 Body mass index; BRCA cis rs6684514 1.000 rs12038203 chr1:156248265 C/T cg16558208 chr1:156270281 VHLL 0.35 7.95 0.3 8.56e-15 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs6714710 0.603 rs116309486 chr2:98493359 A/G cg26665480 chr2:98280029 ACTR1B 0.6 13.75 0.48 6.79e-38 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7552404 0.924 rs7546641 chr1:76158035 T/C cg10523679 chr1:76189770 ACADM 0.88 20.7 0.63 2.98e-73 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs2836974 0.644 rs7281853 chr21:40693490 A/G cg11890956 chr21:40555474 PSMG1 -0.82 -19.5 -0.61 8.45e-67 Cognitive function; BRCA cis rs4713118 0.869 rs6914924 chr6:27711530 C/T cg26587870 chr6:27730563 NA -0.39 -8.26 -0.31 8.11e-16 Parkinson's disease; BRCA cis rs1005277 0.579 rs2103938 chr10:38493998 T/G cg00409905 chr10:38381863 ZNF37A -0.53 -11.49 -0.41 6.42e-28 Extrinsic epigenetic age acceleration; BRCA cis rs35110281 0.632 rs9306160 chr21:45107562 T/C cg04455712 chr21:45112962 RRP1B 0.43 10.6 0.39 2.83e-24 Mean corpuscular volume; BRCA cis rs6484504 0.532 rs7116443 chr11:31283170 T/C cg06552810 chr11:31128660 NA -0.4 -8.88 -0.33 6.88e-18 Red blood cell count; BRCA cis rs35306767 0.714 rs67696450 chr10:1090684 C/T cg26597838 chr10:835615 NA 0.89 13.86 0.48 2.29e-38 Eosinophil percentage of granulocytes; BRCA cis rs2836633 0.929 rs4514962 chr21:40041753 C/T cg05519781 chr21:40033154 ERG 0.44 9.43 0.35 7.2e-20 Coronary artery disease; BRCA cis rs7267979 0.932 rs1985737 chr20:25591468 T/A cg24626310 chr20:25276739 ABHD12;PYGB 0.29 8.21 0.31 1.21e-15 Liver enzyme levels (alkaline phosphatase); BRCA cis rs11105298 0.891 rs10858896 chr12:89920184 C/T cg00757033 chr12:89920650 WDR51B 0.54 11.08 0.4 3.21e-26 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs12142240 0.659 rs1984491 chr1:46858607 T/G cg10495392 chr1:46806563 NSUN4 0.45 8.47 0.32 1.74e-16 Menopause (age at onset); BRCA trans rs629535 0.814 rs604254 chr8:70059164 A/G cg21567404 chr3:27674614 NA 0.99 20.81 0.64 7.73e-74 Dupuytren's disease; BRCA cis rs2836950 0.501 rs11088470 chr21:40689162 A/G cg17971929 chr21:40555470 PSMG1 -0.48 -10.57 -0.39 3.68e-24 Menarche (age at onset); BRCA cis rs911555 0.673 rs7144271 chr14:103890674 A/G cg12935359 chr14:103987150 CKB -0.58 -13.15 -0.46 3.79e-35 Intelligence (multi-trait analysis); BRCA cis rs858239 0.720 rs10227559 chr7:23272144 G/A cg23682824 chr7:23144976 KLHL7 0.35 8.71 0.33 2.57e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs7811142 1.000 rs2406255 chr7:100053690 T/C cg18515655 chr7:100026757 MEPCE;ZCWPW1 -0.82 -12.32 -0.44 1.86e-31 Platelet count; BRCA cis rs473651 0.904 rs508274 chr2:239337723 G/A cg21699342 chr2:239360505 ASB1 0.53 14.2 0.49 5.48e-40 Multiple system atrophy; BRCA cis rs2637030 0.559 rs372006 chr5:52875859 T/A cg06476337 chr5:52856530 NDUFS4 0.38 8.62 0.32 5.24e-17 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs11190604 0.767 rs74869390 chr10:102189385 A/G cg07080220 chr10:102295463 HIF1AN 0.5 10.35 0.38 2.59e-23 Palmitoleic acid (16:1n-7) levels; BRCA cis rs4481887 0.927 rs6671702 chr1:248482851 G/A cg00666640 chr1:248458726 OR2T12 0.3 8.57 0.32 7.54e-17 Common traits (Other); BRCA cis rs78487399 0.908 rs55855805 chr2:43808490 A/G cg06169590 chr2:43455088 ZFP36L2;LOC100129726 -0.51 -7.99 -0.3 6.36e-15 Myeloid white cell count;Granulocyte count;Sum neutrophil eosinophil counts;Sum basophil neutrophil counts;Inflammatory bowel disease; BRCA cis rs7587476 0.626 rs4672729 chr2:215643483 A/G cg04004882 chr2:215674386 BARD1 -0.4 -8.22 -0.31 1.14e-15 Neuroblastoma; BRCA cis rs3849570 0.883 rs28435942 chr3:81679692 C/T cg07356753 chr3:81810745 GBE1 -0.45 -10.63 -0.39 2.04e-24 Waist circumference;Body mass index; BRCA cis rs2797160 0.967 rs1739368 chr6:126011079 C/T cg05901451 chr6:126070800 HEY2 0.4 9.65 0.36 1.14e-20 Endometrial cancer; BRCA cis rs7178424 1.000 rs62008532 chr15:62365877 T/C cg00456672 chr15:62358751 C2CD4A -0.42 -9.43 -0.35 7.5599999999999994e-20 Height; BRCA cis rs2404602 0.735 rs1607015 chr15:76702429 C/T cg23625390 chr15:77176239 SCAPER -0.52 -12.26 -0.44 3.45e-31 Blood metabolite levels; BRCA cis rs477692 0.569 rs1771448 chr10:131296201 A/G cg05714579 chr10:131428358 MGMT -0.45 -10.19 -0.37 1.09e-22 Response to temozolomide; BRCA cis rs877529 0.967 rs139407 chr22:39552075 G/A cg18708252 chr22:39545030 CBX7 -0.32 -8.19 -0.31 1.45e-15 Multiple myeloma; BRCA cis rs763121 0.853 rs5757226 chr22:39070550 T/C cg06544989 chr22:39130855 UNC84B 0.34 7.94 0.3 9.19e-15 Menopause (age at onset); BRCA cis rs7666738 0.606 rs6839946 chr4:99076132 A/C cg05340658 chr4:99064831 C4orf37 0.5 10.99 0.4 7.52e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg00166722 chr3:10149974 C3orf24 0.65 12.8 0.45 1.54e-33 Alzheimer's disease; BRCA cis rs801193 0.660 rs1962050 chr7:66240008 C/T cg18876405 chr7:65276391 NA -0.5 -11.67 -0.42 1.19e-28 Aortic root size; BRCA cis rs12135062 1.000 rs12135062 chr1:3103312 A/C cg00254258 chr1:3105189 PRDM16 0.44 10.38 0.38 1.89e-23 Migraine; BRCA cis rs17376456 0.569 rs10050364 chr5:93064127 T/C cg25358565 chr5:93447407 FAM172A 0.69 11.91 0.43 1.14e-29 Diabetic retinopathy; BRCA cis rs7766436 0.727 rs6908574 chr6:22610165 T/C cg13666174 chr6:22585274 NA -0.36 -9.25 -0.34 3.28e-19 Coronary artery disease; BRCA cis rs35306767 0.668 rs12356612 chr10:1055055 C/T cg10556349 chr10:835070 NA 0.58 8.32 0.31 5.15e-16 Eosinophil percentage of granulocytes; BRCA cis rs1538970 0.739 rs4660863 chr1:45955868 T/C cg05343316 chr1:45956843 TESK2 0.7 14.72 0.5 2e-42 Platelet count; BRCA cis rs10782582 0.569 rs4549990 chr1:76125075 A/G cg03433033 chr1:76189801 ACADM -0.47 -9.86 -0.36 1.94e-21 Daytime sleep phenotypes; BRCA cis rs10504229 0.679 rs11783965 chr8:58130510 T/G cg11062466 chr8:58055876 NA 0.41 7.99 0.3 6.47e-15 Developmental language disorder (linguistic errors); BRCA cis rs7975161 0.506 rs7953434 chr12:104622101 T/G cg25273343 chr12:104657179 TXNRD1 -0.6 -10.33 -0.38 2.98e-23 Toenail selenium levels; BRCA cis rs9807989 0.524 rs2110662 chr2:103020139 A/T cg03938978 chr2:103052716 IL18RAP 0.29 8.51 0.32 1.25e-16 Asthma; BRCA cis rs4727027 0.933 rs10238826 chr7:148830888 A/G cg23583168 chr7:148888333 NA -0.78 -18.85 -0.6 2.33e-63 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs1878931 0.543 rs17612463 chr16:3420479 G/C cg26668626 chr16:3451006 ZNF174;ZNF434 0.5 8.77 0.33 1.61e-17 Body mass index (adult); BRCA cis rs35306767 0.953 rs1539174 chr10:974870 C/G cg20503657 chr10:835505 NA 0.85 15.42 0.52 7.78e-46 Eosinophil percentage of granulocytes; BRCA trans rs8002861 0.935 rs9567299 chr13:44456969 G/A cg17145862 chr1:211918768 LPGAT1 0.73 19.3 0.61 1.01e-65 Leprosy; BRCA trans rs7647973 0.667 rs11721148 chr3:49646669 G/A cg21659725 chr3:3221576 CRBN -0.47 -8.46 -0.32 1.86e-16 Menarche (age at onset); BRCA cis rs1003719 0.715 rs7282195 chr21:38508619 C/T cg10648535 chr21:38446584 PIGP;TTC3 -0.61 -14.19 -0.49 6.29e-40 Eye color traits; BRCA cis rs7312933 0.607 rs7965392 chr12:42540280 G/A cg01256987 chr12:42539512 GXYLT1 -0.48 -9.24 -0.34 3.52e-19 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs1707322 0.721 rs12043945 chr1:46106922 T/A cg03146154 chr1:46216737 IPP 0.52 11.77 0.42 4.62e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4237845 0.844 rs7306124 chr12:58303349 A/T cg00677455 chr12:58241039 CTDSP2 0.43 10.0 0.37 5.45e-22 Intelligence (multi-trait analysis); BRCA cis rs7729447 0.841 rs10941021 chr5:32691144 C/T cg16267343 chr5:32710456 NPR3 0.43 8.95 0.33 3.91e-18 Blood pressure; BRCA cis rs1801251 1.000 rs7578299 chr2:233573469 G/T cg25237894 chr2:233734115 C2orf82 0.4 11.38 0.41 1.84e-27 Coronary artery disease; BRCA trans rs9929218 0.551 rs3785133 chr16:68728611 C/T cg04657470 chr2:198365150 HSPE1;HSPD1 0.99 29.89 0.76 1.81e-123 Colorectal cancer; BRCA cis rs936229 0.690 rs2445618 chr15:75035256 T/C cg14664628 chr15:75095509 CSK -0.86 -23.07 -0.67 4.09e-86 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs589448 0.867 rs623853 chr12:69753830 G/A cg14784868 chr12:69753453 YEATS4 0.79 25.23 0.71 5.18e-98 Cerebrospinal fluid biomarker levels; BRCA cis rs10493773 0.630 rs3753790 chr1:86174772 T/C cg17807903 chr1:86174739 ZNHIT6 -0.53 -13.2 -0.46 2.36e-35 Urate levels in overweight individuals; BRCA cis rs6952808 0.575 rs2056479 chr7:1954273 G/A cg14004847 chr7:1930337 MAD1L1 -0.42 -8.81 -0.33 1.22e-17 Bipolar disorder and schizophrenia; BRCA cis rs2243480 1.000 rs4548056 chr7:65298873 A/G cg18252515 chr7:66147081 NA -0.81 -11.28 -0.41 5.12e-27 Diabetic kidney disease; BRCA cis rs6570726 0.791 rs6913727 chr6:145899826 A/G cg23711669 chr6:146136114 FBXO30 0.74 17.77 0.58 1.06e-57 Lobe attachment (rater-scored or self-reported); BRCA cis rs17270561 0.779 rs17271767 chr6:25886921 C/T cg17691542 chr6:26056736 HIST1H1C 0.71 14.12 0.49 1.38e-39 Iron status biomarkers; BRCA cis rs936229 0.690 rs2472299 chr15:75033400 C/T cg10253484 chr15:75165896 SCAMP2 0.5 9.52 0.35 3.64e-20 Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin); BRCA cis rs11030122 0.702 rs10835340 chr11:3960420 A/G cg18678763 chr11:4115507 RRM1 0.36 8.21 0.31 1.27e-15 Mean platelet volume;Platelet distribution width; BRCA cis rs9291683 0.566 rs13115776 chr4:10040189 C/G cg11266682 chr4:10021025 SLC2A9 0.46 12.19 0.43 7.08e-31 Bone mineral density; BRCA cis rs2303759 0.709 rs8102574 chr19:49828897 A/G cg22307029 chr19:49891270 CCDC155 0.53 8.9 0.33 5.51e-18 Multiple sclerosis; BRCA cis rs2115630 0.967 rs11073731 chr15:85355113 C/A cg11189052 chr15:85197271 WDR73 -0.36 -8.62 -0.32 5.42e-17 P wave terminal force; BRCA cis rs10911232 0.524 rs4652773 chr1:183054827 A/G ch.1.3577855R chr1:183094577 LAMC1 0.65 16.8 0.55 9.46e-53 Hypertriglyceridemia; BRCA cis rs651907 0.557 rs36002990 chr3:101437862 G/A cg21474964 chr3:101395104 ZBTB11;LOC100009676 0.6 14.69 0.5 2.56e-42 Colorectal cancer; BRCA cis rs6484504 0.625 rs10835766 chr11:31374329 C/A cg26647111 chr11:31128758 NA 0.42 9.33 0.35 1.72e-19 Red blood cell count; BRCA cis rs35306767 0.903 rs35957139 chr10:884889 C/T cg10556349 chr10:835070 NA 0.75 10.1 0.37 2.41e-22 Eosinophil percentage of granulocytes; BRCA cis rs8062405 0.964 rs72793809 chr16:28832382 C/T cg09754948 chr16:28834200 ATXN2L 0.46 9.12 0.34 9.55e-19 Cognitive ability (multi-trait analysis);Cognitive ability; BRCA cis rs10504229 0.775 rs17216236 chr8:58159352 G/A cg24829409 chr8:58192753 C8orf71 -0.46 -7.86 -0.3 1.67e-14 Developmental language disorder (linguistic errors); BRCA cis rs9381040 0.610 rs9394758 chr6:41017821 C/T cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -9.0 -0.34 2.53e-18 Alzheimer's disease (late onset); BRCA cis rs10479542 0.766 rs6894980 chr5:178974592 C/T cg21226059 chr5:178986404 RUFY1 0.4 10.43 0.38 1.21e-23 Lung cancer; BRCA cis rs6565180 0.962 rs11642676 chr16:30371655 C/G cg17640201 chr16:30407289 ZNF48 -0.74 -15.9 -0.53 3.17e-48 Tonsillectomy; BRCA cis rs17401966 1.000 rs58549151 chr1:10314657 A/C cg15208524 chr1:10270712 KIF1B 0.39 8.43 0.32 2.24e-16 Hepatocellular carcinoma; BRCA cis rs7937682 0.632 rs11214029 chr11:111761230 C/T cg09085632 chr11:111637200 PPP2R1B 0.75 14.71 0.5 2.12e-42 Primary sclerosing cholangitis; BRCA cis rs6860806 0.695 rs6867282 chr5:131583120 G/C cg18301423 chr5:131593218 PDLIM4 0.33 8.69 0.33 3.08e-17 Breast cancer; BRCA cis rs7255436 0.928 rs7250870 chr19:8453682 C/T cg10174797 chr19:8464628 RAB11B 0.37 9.37 0.35 1.22e-19 HDL cholesterol; BRCA cis rs9443645 0.901 rs9341754 chr6:79584973 A/C cg05283184 chr6:79620031 NA -0.43 -11.1 -0.4 2.77e-26 Intelligence (multi-trait analysis); BRCA cis rs7666738 0.791 rs13120773 chr4:98972589 C/T cg17366294 chr4:99064904 C4orf37 0.45 10.58 0.39 3.37e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs2051211 0.895 rs2300670 chr3:38555815 A/G cg01465620 chr3:38496096 LOC100128640;ACVR2B -0.48 -9.45 -0.35 6.2e-20 QRS duration; BRCA cis rs2677744 0.626 rs12915155 chr15:91490894 G/T cg23684204 chr15:91497937 RCCD1 0.45 9.08 0.34 1.32e-18 Attention deficit hyperactivity disorder; BRCA trans rs9951602 1.000 rs9949784 chr18:76649994 A/G cg02800362 chr5:177631904 HNRNPAB 0.75 13.03 0.46 1.3600000000000001e-34 Obesity-related traits; BRCA cis rs12791968 0.765 rs12794846 chr11:44998943 C/T cg11846598 chr11:44996168 LOC221122 0.46 8.33 0.31 4.84e-16 Inhibitory control; BRCA cis rs7246657 0.882 rs10422667 chr19:37937876 T/C cg23950597 chr19:37808831 NA -0.74 -13.09 -0.46 7.77e-35 Coronary artery calcification; BRCA cis rs908922 0.676 rs549044 chr1:152514332 C/T cg20991723 chr1:152506922 NA 0.39 8.99 0.33 2.83e-18 Hair morphology; BRCA trans rs7618501 0.699 rs2681781 chr3:49898273 A/G cg21659725 chr3:3221576 CRBN 0.53 13.67 0.48 1.61e-37 Intelligence (multi-trait analysis); BRCA cis rs2204008 0.837 rs11183232 chr12:37941053 A/G cg26384229 chr12:38710491 ALG10B 0.66 15.11 0.51 2.4e-44 Bladder cancer; BRCA cis rs2304069 0.817 rs216132 chr5:149431259 C/T cg10852222 chr5:149380144 HMGXB3;TIGD6 -0.47 -7.9 -0.3 1.25e-14 HIV-1 control; BRCA cis rs8177253 0.965 rs4854761 chr3:133498789 A/G cg01448562 chr3:133502909 NA 0.58 13.76 0.48 6.36e-38 Iron status biomarkers; BRCA cis rs6121246 0.559 rs6087771 chr20:30306724 A/G cg13852791 chr20:30311386 BCL2L1 0.97 23.69 0.68 1.64e-89 Mean corpuscular hemoglobin; BRCA cis rs698813 0.572 rs6544749 chr2:44478077 G/A cg18685995 chr2:44588913 PREPL;C2orf34 0.47 8.28 0.31 7.36e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs13256369 0.802 rs11249888 chr8:8564934 T/C cg17143192 chr8:8559678 CLDN23 0.57 11.17 0.4 1.35e-26 Obesity-related traits; BRCA cis rs7246657 0.524 rs10411251 chr19:37428755 C/T cg14683738 chr19:37701593 ZNF585B 0.57 9.34 0.35 1.6e-19 Coronary artery calcification; BRCA cis rs6066835 1.000 rs6066830 chr20:47353897 C/T cg18078177 chr20:47281410 PREX1 0.69 8.6 0.32 6.2e-17 Multiple myeloma; BRCA cis rs4970988 0.640 rs7524734 chr1:150655686 C/T cg04414720 chr1:150670196 GOLPH3L 0.34 7.83 0.3 2.03e-14 Urate levels; BRCA cis rs7666738 0.830 rs34273190 chr4:99004568 C/T cg05340658 chr4:99064831 C4orf37 0.69 17.49 0.57 3.01e-56 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.656 rs73048919 chr7:2103637 C/A cg00106254 chr7:1943704 MAD1L1 -0.44 -11.03 -0.4 5.02e-26 Bipolar disorder and schizophrenia; BRCA cis rs78456975 0.739 rs11896906 chr2:1519550 A/G cg26248373 chr2:1572462 NA -0.52 -10.58 -0.39 3.38e-24 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs708547 1.000 rs708547 chr4:57821309 T/C cg16868167 chr4:57843880 C4orf14;POLR2B 0.48 11.06 0.4 4.05e-26 Response to bleomycin (chromatid breaks); BRCA cis rs67079557 1 rs67079557 chr15:75930300 ATAATAAG/A cg20655648 chr15:75932815 IMP3 0.51 9.91 0.36 1.26e-21 Breast cancer; BRCA cis rs6815814 0.950 rs5743593 chr4:38802913 A/G cg02016764 chr4:38805732 TLR1 -0.61 -9.75 -0.36 5.03e-21 Breast cancer; BRCA cis rs4363385 0.818 rs4845522 chr1:153011099 C/T cg24667326 chr1:152973720 SPRR3 -0.34 -9.3 -0.35 2.17e-19 Inflammatory skin disease; BRCA cis rs9527 0.590 rs7917650 chr10:104937100 G/C cg04362960 chr10:104952993 NT5C2 0.42 9.63 0.36 1.34e-20 Arsenic metabolism; BRCA cis rs4285028 0.747 rs9817818 chr3:121466826 C/A cg01951420 chr3:121553821 IQCB1;EAF2 -0.7 -13.87 -0.48 2.07e-38 Multiple sclerosis; BRCA cis rs826838 0.967 rs73096706 chr12:38860563 G/A cg26384229 chr12:38710491 ALG10B 0.84 21.88 0.65 1.18e-79 Heart rate; BRCA cis rs2153535 0.580 rs6597327 chr6:8482157 G/A cg21535247 chr6:8435926 SLC35B3 0.39 8.95 0.33 3.68e-18 Motion sickness; BRCA cis rs12612619 0.732 rs7560144 chr2:27280460 A/G cg00617064 chr2:27272375 NA -0.33 -8.87 -0.33 7.31e-18 Venous thromboembolism adjusted for sickle cell variant rs77121243-T; BRCA cis rs9487051 0.872 rs9386791 chr6:109608497 C/T cg21918786 chr6:109611834 NA -0.49 -14.24 -0.49 3.6e-40 Reticulocyte fraction of red cells; BRCA cis rs870825 0.860 rs72689284 chr4:185596680 A/G cg04058563 chr4:185651563 MLF1IP 0.85 14.29 0.49 2.16e-40 Blood protein levels; BRCA cis rs7666738 0.830 rs7691864 chr4:98971376 G/C cg05340658 chr4:99064831 C4orf37 0.66 16.1 0.54 3.26e-49 Colonoscopy-negative controls vs population controls; BRCA cis rs3806843 0.705 rs35614340 chr5:140043618 C/G cg26395211 chr5:140044315 WDR55 0.37 8.61 0.32 5.55e-17 Depressive symptoms (multi-trait analysis); BRCA cis rs1865760 0.566 rs9348706 chr6:26065481 G/C cg16482183 chr6:26056742 HIST1H1C 0.53 11.42 0.41 1.3e-27 Height; BRCA cis rs4285028 0.948 rs7615571 chr3:121665950 A/C cg01951420 chr3:121553821 IQCB1;EAF2 -0.58 -10.77 -0.39 5.85e-25 Multiple sclerosis; BRCA trans rs3780486 0.846 rs913214 chr9:33135085 G/A cg04842962 chr6:43655489 MRPS18A 1.12 38.72 0.84 9.92e-170 IgG glycosylation; BRCA cis rs698833 0.532 rs698809 chr2:44702978 C/T cg18685995 chr2:44588913 PREPL;C2orf34 -0.47 -8.6 -0.32 6.2e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs911555 0.755 rs7147664 chr14:103963420 G/A cg12935359 chr14:103987150 CKB -0.61 -13.96 -0.48 7.3e-39 Intelligence (multi-trait analysis); BRCA cis rs11190604 1.000 rs12219158 chr10:102302923 T/C cg07080220 chr10:102295463 HIF1AN 0.65 15.51 0.52 2.69e-46 Palmitoleic acid (16:1n-7) levels; BRCA cis rs709400 0.633 rs8013101 chr14:103951772 G/C cg24130564 chr14:104152367 KLC1 -0.34 -7.84 -0.3 1.86e-14 Body mass index; BRCA trans rs7395662 0.504 rs11039701 chr11:48389838 A/G cg15704280 chr7:45808275 SEPT13 -0.42 -8.15 -0.31 1.99e-15 HDL cholesterol; BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg04166393 chr7:2884313 GNA12 0.52 9.93 0.37 1.01e-21 Height; BRCA cis rs250677 0.522 rs10040598 chr5:148365720 C/A cg12140854 chr5:148520817 ABLIM3 0.41 8.34 0.31 4.44e-16 Breast cancer; BRCA cis rs7552404 0.824 rs1251079 chr1:76189445 C/T cg03433033 chr1:76189801 ACADM 0.88 27.72 0.74 1.13e-111 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs7149337 0.837 rs10132658 chr14:51677599 C/T cg23942311 chr14:51606299 NA 0.43 12.13 0.43 1.26e-30 Cancer; BRCA cis rs6570726 0.791 rs9373466 chr6:145912016 T/C cg23711669 chr6:146136114 FBXO30 0.73 17.3 0.56 2.77e-55 Lobe attachment (rater-scored or self-reported); BRCA cis rs992157 0.965 rs62182826 chr2:219148723 C/A cg20019365 chr2:219134978 PNKD;AAMP 0.6 13.68 0.48 1.54e-37 Colorectal cancer; BRCA cis rs1862618 0.853 rs832565 chr5:56150803 T/G cg20203395 chr5:56204925 C5orf35 -0.5 -10.16 -0.37 1.36e-22 Initial pursuit acceleration; BRCA trans rs2204008 0.715 rs11525003 chr12:38332359 G/A cg06521331 chr12:34319734 NA -0.48 -8.79 -0.33 1.39e-17 Bladder cancer; BRCA cis rs7582720 0.887 rs72934589 chr2:204017937 C/T cg15057621 chr2:203777863 WDR12;ALS2CR8 0.81 12.75 0.45 2.48e-33 Coronary artery disease or ischemic stroke;Coronary artery disease or large artery stroke; BRCA cis rs6484504 0.576 rs441975 chr11:31233351 C/T cg14844989 chr11:31128820 NA -0.45 -9.65 -0.36 1.14e-20 Red blood cell count; BRCA cis rs60871478 0.635 rs4311567 chr7:792295 T/C cg06242242 chr7:766104 PRKAR1B;HEATR2 0.57 8.35 0.31 4.08e-16 Cerebrospinal P-tau181p levels; BRCA cis rs2806561 0.765 rs1738468 chr1:23510850 T/G cg12483005 chr1:23474871 LUZP1 0.45 10.13 0.37 1.83e-22 Height; BRCA trans rs8073060 0.586 rs225278 chr17:33974170 C/T cg19694781 chr19:47549865 TMEM160 -1.04 -21.19 -0.64 6.54e-76 Immature fraction of reticulocytes;Platelet count;Platelet distribution width; BRCA cis rs9287719 0.934 rs6710033 chr2:10757677 C/T cg02196655 chr2:10830764 NOL10 -0.3 -7.99 -0.3 6.39e-15 Prostate cancer; BRCA cis rs6460942 0.597 rs13227809 chr7:12525557 G/A cg06484146 chr7:12443880 VWDE -0.58 -7.8 -0.3 2.45e-14 Coronary artery disease; BRCA cis rs473651 1.000 rs473651 chr2:239335401 A/C cg14266287 chr2:239334506 ASB1 -0.34 -8.24 -0.31 1.01e-15 Multiple system atrophy; BRCA cis rs829883 0.659 rs11109510 chr12:98911382 A/G cg25150519 chr12:98850993 NA -0.51 -9.37 -0.35 1.2e-19 Colorectal adenoma (advanced); BRCA cis rs4665809 0.887 rs28699126 chr2:26357294 C/T cg04944784 chr2:26401820 FAM59B -0.66 -11.28 -0.41 4.88e-27 Gut microbiome composition (summer); BRCA cis rs798554 0.797 rs1182183 chr7:2873136 C/T cg19346786 chr7:2764209 NA -0.34 -10.01 -0.37 5.15e-22 Height; BRCA cis rs2180341 1.000 rs9398837 chr6:127635217 G/A cg24812749 chr6:127587940 RNF146 0.88 20.78 0.63 1.21e-73 Breast cancer; BRCA cis rs6977660 1.000 rs57916046 chr7:19800542 T/C cg05791153 chr7:19748676 TWISTNB 0.47 9.11 0.34 1.06e-18 Thyroid stimulating hormone; BRCA cis rs453301 0.658 rs3855900 chr8:8901921 A/G cg06636001 chr8:8085503 FLJ10661 -0.48 -10.17 -0.37 1.26e-22 Joint mobility (Beighton score); BRCA cis rs7937890 0.900 rs7118682 chr11:14274550 T/G cg22961513 chr11:14280813 SPON1 0.31 7.91 0.3 1.11e-14 Mitochondrial DNA levels; BRCA cis rs7191700 0.601 rs243329 chr16:11352313 A/T cg00044050 chr16:11439710 C16orf75 0.38 9.05 0.34 1.74e-18 Multiple sclerosis; BRCA cis rs6088590 0.542 rs6059956 chr20:33220070 A/G cg24642439 chr20:33292090 TP53INP2 0.54 12.03 0.43 3.4e-30 Coronary artery disease; BRCA trans rs7980799 0.649 rs2389215 chr12:33649457 C/T cg26384229 chr12:38710491 ALG10B -0.44 -9.63 -0.36 1.4e-20 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs9868809 0.505 rs73080312 chr3:48737847 C/T cg00383909 chr3:49044727 WDR6 0.92 13.01 0.46 1.72e-34 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs2777491 0.915 rs7165675 chr15:41614704 T/C cg18705301 chr15:41695430 NDUFAF1 -0.61 -13.87 -0.48 1.89e-38 Ulcerative colitis; BRCA cis rs6951245 1.000 rs113146460 chr7:1105164 C/G cg20603222 chr7:1096387 C7orf50;GPR146 -0.94 -15.71 -0.53 2.9e-47 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA trans rs75804782 0.572 rs74979875 chr2:239302568 G/A cg01134436 chr17:81009848 B3GNTL1 0.74 7.87 0.3 1.49e-14 Morning vs. evening chronotype;Chronotype; BRCA cis rs2243480 1.000 rs35432774 chr7:65393019 G/C cg18252515 chr7:66147081 NA -0.82 -11.98 -0.43 5.61e-30 Diabetic kidney disease; BRCA cis rs6684514 0.922 rs12047994 chr1:156284535 C/A cg16558208 chr1:156270281 VHLL 0.36 8.43 0.32 2.35e-16 Mean corpuscular hemoglobin concentration;Glycated hemoglobin levels; BRCA cis rs3780378 0.870 rs2149556 chr9:5059440 C/T cg02405213 chr9:5042618 JAK2 -0.44 -8.88 -0.33 6.86e-18 Eosinophil percentage of white cells;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes; BRCA cis rs875971 0.651 rs313829 chr7:65552497 A/G cg18876405 chr7:65276391 NA -0.47 -9.37 -0.35 1.23e-19 Aortic root size; BRCA trans rs3857536 0.776 rs4710316 chr6:66935097 T/A cg15611600 chr13:45563400 KIAA1704;NUFIP1 -0.4 -8.13 -0.31 2.24e-15 Blood trace element (Cu levels); BRCA cis rs13631 0.894 rs7856589 chr9:140003921 A/G cg03717367 chr9:139980219 LOC100289341;MAN1B1 -0.36 -8.62 -0.32 5.3e-17 Cerebrospinal fluid biomarker levels; BRCA cis rs243505 0.898 rs243542 chr7:148403194 G/A cg09806900 chr7:148480153 CUL1 -0.39 -8.09 -0.3 3.11e-15 Inflammatory bowel disease;Crohn's disease; BRCA cis rs877282 0.842 rs35872126 chr10:764545 G/A cg17470449 chr10:769945 NA 0.47 7.96 0.3 8.16e-15 Uric acid levels; BRCA cis rs2637266 1.000 rs2395389 chr10:78357701 C/T cg18941641 chr10:78392320 NA 0.35 7.82 0.3 2.23e-14 Pulmonary function; BRCA cis rs7249142 0.549 rs539 chr19:19287802 A/G cg08207377 chr19:19281140 LOC729991-MEF2B;MEF2B -0.51 -11.3 -0.41 4.05e-27 IgG glycosylation; BRCA cis rs72781680 0.898 rs72780125 chr2:24000145 T/C cg08917208 chr2:24149416 ATAD2B 1.06 14.87 0.51 3.6e-43 Lymphocyte counts; BRCA cis rs2242116 0.727 rs4683298 chr3:46966387 C/G cg02527881 chr3:46936655 PTH1R -0.4 -9.54 -0.35 2.91e-20 Birth weight; BRCA cis rs2239547 0.522 rs9844736 chr3:52931971 T/G cg11645453 chr3:52864694 ITIH4 -0.47 -11.54 -0.42 4.2e-28 Schizophrenia; BRCA trans rs7618501 1.000 rs7372730 chr3:49790682 C/G cg21659725 chr3:3221576 CRBN -0.71 -21.71 -0.65 1.02e-78 Intelligence (multi-trait analysis); BRCA cis rs4713118 0.621 rs10484403 chr6:28033523 A/G cg02631126 chr6:28058918 ZSCAN12L1 0.28 8.15 0.31 1.9e-15 Parkinson's disease; BRCA cis rs2180341 0.924 rs9285459 chr6:127631113 T/C cg27446573 chr6:127587934 RNF146 0.9 21.49 0.65 1.64e-77 Breast cancer; BRCA cis rs9443645 0.901 rs9448584 chr6:79572799 G/T cg05283184 chr6:79620031 NA -0.41 -10.78 -0.39 5.22e-25 Intelligence (multi-trait analysis); BRCA cis rs1568889 0.838 rs12273631 chr11:28042135 A/T cg06544937 chr11:28130018 METT5D1;KIF18A 0.79 20.33 0.63 2.95e-71 Bipolar disorder; BRCA cis rs10992471 0.603 rs1121978 chr9:95140351 T/G cg14631576 chr9:95140430 CENPP -0.4 -9.71 -0.36 6.96e-21 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7246657 0.943 rs10407084 chr19:37907792 T/C cg23950597 chr19:37808831 NA -0.74 -13.06 -0.46 1.05e-34 Coronary artery calcification; BRCA cis rs7615952 0.641 rs7632497 chr3:125783086 A/C cg15145296 chr3:125709740 NA -0.55 -8.81 -0.33 1.13e-17 Blood pressure (smoking interaction); BRCA cis rs10883723 0.810 rs1884929 chr10:104275418 C/T cg11453585 chr10:104263688 ACTR1A;SUFU 0.64 20.06 0.62 8.66e-70 Allergic disease (asthma, hay fever or eczema); BRCA cis rs7178424 0.742 rs12908081 chr15:62162264 C/T cg00456672 chr15:62358751 C2CD4A -0.37 -8.9 -0.33 5.79e-18 Height; BRCA cis rs2479724 0.905 rs2274578 chr6:41888827 C/G cg17623882 chr6:41773611 USP49 -0.37 -10.1 -0.37 2.44e-22 Menarche (age at onset); BRCA cis rs4908768 0.539 rs1318218 chr1:8658712 T/C cg20416874 chr1:8611966 RERE -0.29 -8.2 -0.31 1.27e-15 Neuroticism (multi-trait analysis);Subjective well-being (multi-trait analysis); BRCA cis rs72781680 1.000 rs17762782 chr2:24126493 A/G cg08917208 chr2:24149416 ATAD2B 0.93 13.86 0.48 2.21e-38 Lymphocyte counts; BRCA cis rs13118159 0.509 rs1882098 chr4:1352431 T/C cg20887711 chr4:1340912 KIAA1530 0.71 15.53 0.52 2.16e-46 Longevity; BRCA cis rs13191362 1.000 rs34653853 chr6:163114362 C/T cg06582575 chr6:163149167 PACRG;PARK2 1.01 14.96 0.51 1.29e-43 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs17685 0.712 rs10275521 chr7:75770972 T/C cg19862616 chr7:65841803 NCRNA00174 0.83 27.56 0.74 8.71e-111 Coffee consumption;Coffee consumption (cups per day); BRCA cis rs6598955 0.724 rs12757113 chr1:26597144 C/T cg00852783 chr1:26633632 UBXN11 0.52 12.36 0.44 1.29e-31 Obesity-related traits; BRCA cis rs7851660 0.967 rs7860598 chr9:100600702 G/A cg13688889 chr9:100608707 NA -0.36 -8.61 -0.32 5.84e-17 Strep throat; BRCA cis rs941764 0.965 rs941765 chr14:91841358 G/C cg10511902 chr14:91842949 CCDC88C 0.54 13.97 0.48 6.65e-39 Breast cancer; BRCA cis rs11718455 0.960 rs13059547 chr3:44004492 G/A cg08738300 chr3:44038990 NA 0.45 8.71 0.33 2.55e-17 Coronary artery disease; BRCA cis rs7100689 0.542 rs7096715 chr10:82195949 T/C cg00277334 chr10:82204260 NA -0.59 -13.4 -0.47 2.77e-36 Post bronchodilator FEV1; BRCA cis rs1008375 0.932 rs4698626 chr4:17605821 G/C cg16339924 chr4:17578868 LAP3 0.62 15.43 0.52 6.61e-46 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs858239 0.712 rs200717 chr7:23392271 A/G cg23682824 chr7:23144976 KLHL7 0.33 8.36 0.31 3.83e-16 Cerebrospinal fluid biomarker levels; BRCA cis rs6461049 0.766 rs10256077 chr7:2171450 C/T cg00106254 chr7:1943704 MAD1L1 0.32 8.62 0.32 5.08e-17 Schizophrenia; BRCA cis rs6089584 0.927 rs2296083 chr20:60574216 C/T cg06108461 chr20:60628389 TAF4 -0.78 -17.05 -0.56 5.54e-54 Body mass index; BRCA cis rs763121 0.853 rs3827357 chr22:39079413 A/G cg06022373 chr22:39101656 GTPBP1 0.75 18.41 0.59 4.74e-61 Menopause (age at onset); BRCA cis rs2836974 0.627 rs8127986 chr21:40687211 A/T cg11890956 chr21:40555474 PSMG1 -0.83 -20.56 -0.63 1.72e-72 Cognitive function; BRCA cis rs921968 0.573 rs684776 chr2:219324016 T/C cg02176678 chr2:219576539 TTLL4 0.46 11.88 0.43 1.57e-29 Mean corpuscular hemoglobin concentration; BRCA cis rs2576037 0.583 rs8098948 chr18:44512332 C/A cg07416455 chr18:44543612 TCEB3CL;KATNAL2 -0.52 -10.55 -0.39 4.14e-24 Personality dimensions; BRCA cis rs826838 1.000 rs11183196 chr12:38685915 G/T cg26384229 chr12:38710491 ALG10B 0.87 23.71 0.68 1.15e-89 Heart rate; BRCA cis rs11608355 0.545 rs11066782 chr12:109910552 C/T cg05360138 chr12:110035743 NA 0.71 13.09 0.46 7.36e-35 Neuroticism; BRCA cis rs1865760 0.963 rs3846838 chr6:25911775 T/C cg17691542 chr6:26056736 HIST1H1C 0.51 10.43 0.38 1.29e-23 Height; BRCA cis rs8177253 0.665 rs11921527 chr3:133441167 G/A cg01448562 chr3:133502909 NA -0.41 -9.48 -0.35 4.87e-20 Iron status biomarkers; BRCA cis rs703842 1.000 rs11172343 chr12:58188157 T/C cg18357645 chr12:58087776 OS9 -0.33 -8.0 -0.3 5.66e-15 Multiple sclerosis; BRCA cis rs9420 0.961 rs12807250 chr11:57600285 C/T cg19752551 chr11:57585705 CTNND1 -0.51 -12.68 -0.45 4.94e-33 Schizophrenia; BRCA cis rs367943 1.000 rs2248930 chr5:112811119 G/T cg12552261 chr5:112820674 MCC -0.56 -12.28 -0.44 2.97e-31 Type 2 diabetes; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg18765753 chr7:1198926 ZFAND2A -0.37 -8.27 -0.31 7.69e-16 Longevity;Endometriosis; BRCA cis rs7811142 1.000 rs7783550 chr7:99987805 A/G cg01860168 chr7:100026446 MEPCE;ZCWPW1 -0.56 -9.04 -0.34 1.88e-18 Platelet count; BRCA cis rs12971120 0.891 rs2303463 chr18:72168608 G/A cg26446133 chr18:72167187 CNDP2 -0.75 -14.38 -0.49 7.57e-41 Refractive error; BRCA trans rs6089829 1.000 rs6089829 chr20:61669036 C/T cg15934090 chr1:100435551 SLC35A3 -0.33 -7.98 -0.3 6.82e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg12373951 chr3:133503437 NA 0.46 10.84 0.39 2.95e-25 Iron status biomarkers; BRCA cis rs9814567 1.000 rs6766818 chr3:134226159 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.59 -19.8 -0.62 2.12e-68 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs2404602 0.552 rs11630185 chr15:76959783 A/T cg23625390 chr15:77176239 SCAPER -0.52 -10.94 -0.4 1.21e-25 Blood metabolite levels; BRCA cis rs2180341 0.814 rs6919277 chr6:127738050 T/C cg27446573 chr6:127587934 RNF146 0.7 15.98 0.53 1.35e-48 Breast cancer; BRCA cis rs561341 1.000 rs117979353 chr17:30272866 A/G cg12193833 chr17:30244370 NA -0.61 -9.25 -0.34 3.3e-19 Hip circumference adjusted for BMI; BRCA cis rs7829975 0.626 rs907183 chr8:8729761 C/G cg15556689 chr8:8085844 FLJ10661 -0.43 -11.83 -0.42 2.48e-29 Mood instability; BRCA cis rs7091068 0.522 rs866674 chr10:95487515 A/G cg20715218 chr10:95462985 C10orf4 0.48 9.17 0.34 6.54e-19 Urinary tract infection frequency; BRCA cis rs56399783 0.614 rs73047368 chr7:2766396 G/T cg23627948 chr7:2760692 NA 0.54 8.84 0.33 8.98e-18 Childhood ear infection; BRCA cis rs7312933 0.612 rs10785334 chr12:42620377 A/G cg01256987 chr12:42539512 GXYLT1 0.43 8.06 0.3 3.76e-15 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs651907 0.535 rs34063583 chr3:101509948 C/T cg11279151 chr3:101281821 RG9MTD1 -0.37 -8.35 -0.31 4.34e-16 Colorectal cancer; BRCA cis rs7246657 0.943 rs2081096 chr19:37964700 G/A cg18154014 chr19:37997991 ZNF793 0.47 9.31 0.35 1.99e-19 Coronary artery calcification; BRCA cis rs4819052 0.851 rs2838848 chr21:46671017 A/G cg02159808 chr21:46707872 POFUT2;LOC642852 0.51 9.61 0.36 1.7e-20 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs708547 0.533 rs3806746 chr4:57773330 C/T cg25525207 chr4:57843836 C4orf14;POLR2B 0.42 8.1 0.31 2.83e-15 Response to bleomycin (chromatid breaks); BRCA trans rs11098499 0.909 rs7681214 chr4:120385320 C/A cg25214090 chr10:38739885 LOC399744 0.57 13.01 0.46 1.79e-34 Corneal astigmatism; BRCA cis rs7246967 0.611 rs62120457 chr19:22958519 A/G cg23217946 chr19:22817039 ZNF492 0.5 9.1 0.34 1.14e-18 Bronchopulmonary dysplasia; BRCA cis rs875971 0.830 rs4718358 chr7:65973668 T/C cg11764359 chr7:65958608 NA 0.8 19.1 0.6 1.14e-64 Aortic root size; BRCA cis rs9325144 0.556 rs34565156 chr12:39028239 G/A cg26384229 chr12:38710491 ALG10B -0.48 -11.36 -0.41 2.26e-27 Morning vs. evening chronotype; BRCA cis rs4660306 1.000 rs10157597 chr1:45990278 C/A cg03123370 chr1:45965343 CCDC163P;MMACHC -0.39 -7.89 -0.3 1.32e-14 Homocysteine levels; BRCA cis rs4665809 0.549 rs17527979 chr2:26428132 A/G cg22920501 chr2:26401640 FAM59B -0.9 -14.24 -0.49 3.68e-40 Gut microbiome composition (summer); BRCA cis rs9858542 0.543 rs2230929 chr3:49343175 G/A cg00383909 chr3:49044727 WDR6 0.52 10.07 0.37 3.08e-22 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs2635047 0.875 rs2251948 chr18:44681356 A/T cg20875182 chr18:44561130 TCEB3B;KATNAL2 0.38 8.3 0.31 6.15e-16 Educational attainment; BRCA cis rs6088813 1.000 rs6087702 chr20:33995945 T/A cg14752227 chr20:34000481 UQCC -0.39 -8.41 -0.32 2.76e-16 Height; BRCA cis rs11696845 0.776 rs6073538 chr20:43379264 A/C cg25301532 chr20:43378953 KCNK15 0.45 10.73 0.39 8.29e-25 Obesity-related traits; BRCA cis rs10504229 0.683 rs72650847 chr8:58136825 C/T cg11062466 chr8:58055876 NA 0.52 8.9 0.33 5.5e-18 Developmental language disorder (linguistic errors); BRCA cis rs7072216 0.763 rs2274245 chr10:100175082 C/T cg26618903 chr10:100175079 PYROXD2 -0.33 -9.72 -0.36 6.33e-21 Metabolite levels; BRCA cis rs10493773 0.609 rs11161656 chr1:86182414 A/G cg17807903 chr1:86174739 ZNHIT6 -0.54 -13.39 -0.47 3.18e-36 Urate levels in overweight individuals; BRCA cis rs9868809 0.505 rs9877685 chr3:48748588 C/T cg07636037 chr3:49044803 WDR6 -0.58 -7.94 -0.3 8.9e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs6964587 0.610 rs6950682 chr7:91464218 G/T cg17063962 chr7:91808500 NA 0.54 12.32 0.44 1.86e-31 Breast cancer; BRCA cis rs1971762 0.563 rs4759284 chr12:54079491 G/A cg23533419 chr12:54090519 NA -0.33 -8.3 -0.31 6.05e-16 Height; BRCA cis rs4665809 0.590 rs7588328 chr2:26469788 G/A cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.85 0.36 2.04e-21 Gut microbiome composition (summer); BRCA cis rs514406 0.929 rs555741 chr1:53318851 T/G cg27535305 chr1:53392650 SCP2 -0.37 -9.32 -0.35 1.85e-19 Monocyte count; BRCA cis rs6089829 1.000 rs62207535 chr20:61669187 A/G cg08564027 chr20:61660810 NA 0.89 23.44 0.68 3.86e-88 Prostate cancer (SNP x SNP interaction); BRCA cis rs7103648 0.669 rs7131262 chr11:47836302 T/A cg03711944 chr11:47377212 SPI1 -0.38 -8.78 -0.33 1.48e-17 Diastolic blood pressure;Systolic blood pressure; BRCA cis rs35306767 0.903 rs11813210 chr10:919796 G/A cg26597838 chr10:835615 NA 1.02 17.81 0.58 6.47e-58 Eosinophil percentage of granulocytes; BRCA cis rs7640424 0.819 rs179046 chr3:107840773 A/C cg09227934 chr3:107805635 CD47 -0.4 -8.38 -0.31 3.38e-16 Body mass index; BRCA cis rs6121246 0.954 rs7266148 chr20:30431070 G/T cg13852791 chr20:30311386 BCL2L1 0.82 15.58 0.52 1.24e-46 Mean corpuscular hemoglobin; BRCA cis rs72781680 0.611 rs56113233 chr2:24341085 A/C cg08917208 chr2:24149416 ATAD2B 0.55 8.35 0.31 4.17e-16 Lymphocyte counts; BRCA cis rs778371 0.723 rs283470 chr2:233656918 G/A cg08000102 chr2:233561755 GIGYF2 0.82 19.95 0.62 3.33e-69 Schizophrenia; BRCA cis rs2739330 0.828 rs5751770 chr22:24252842 A/G cg15242686 chr22:24348715 GSTTP1 0.34 8.38 0.31 3.41e-16 Liver enzyme levels (gamma-glutamyl transferase); BRCA cis rs11123170 0.569 rs1049137 chr2:113975110 A/G cg11763394 chr2:113992921 PAX8;LOC440839;LOC654433 0.63 10.18 0.37 1.2e-22 Renal function-related traits (BUN); BRCA cis rs9467773 0.620 rs2451737 chr6:26619041 T/C cg09904177 chr6:26538194 HMGN4 0.47 14.71 0.5 2.11e-42 Intelligence (multi-trait analysis); BRCA cis rs6815814 0.950 rs11727978 chr4:38811051 T/A cg02016764 chr4:38805732 TLR1 -0.6 -9.25 -0.34 3.22e-19 Breast cancer; BRCA cis rs1005277 0.522 rs1208681 chr10:38092975 C/T cg25427524 chr10:38739819 LOC399744 -0.65 -15.64 -0.53 6.7e-47 Extrinsic epigenetic age acceleration; BRCA cis rs36051895 0.632 rs117896567 chr9:5141281 C/G cg02405213 chr9:5042618 JAK2 -0.51 -9.5 -0.35 4.07e-20 Pediatric autoimmune diseases; BRCA cis rs13095912 0.512 rs115865582 chr3:185308598 A/C cg11274856 chr3:185301563 NA 0.53 12.6 0.45 1.12e-32 Systolic blood pressure; BRCA cis rs4665809 0.589 rs4665842 chr2:26448954 A/G cg27170947 chr2:26402098 FAM59B -0.92 -16.52 -0.55 2.6e-51 Gut microbiome composition (summer); BRCA cis rs2832191 0.791 rs9983651 chr21:30491227 T/A cg08807101 chr21:30365312 RNF160 -0.6 -15.0 -0.51 8.49e-44 Dental caries; BRCA cis rs9393692 0.905 rs9379843 chr6:26289435 A/G cg00631329 chr6:26305371 NA -0.43 -12.88 -0.45 6.55e-34 Educational attainment; BRCA cis rs7572733 0.534 rs700670 chr2:198687284 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.24 0.38 7.08e-23 Dermatomyositis; BRCA cis rs2153535 0.580 rs2152348 chr6:8474301 C/A cg23788917 chr6:8435910 SLC35B3 0.48 10.39 0.38 1.77e-23 Motion sickness; BRCA cis rs7552404 1.000 rs7534754 chr1:76185308 G/A cg03433033 chr1:76189801 ACADM 0.76 17.21 0.56 8.42e-55 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs9858542 0.537 rs9874474 chr3:49326178 A/G cg00383909 chr3:49044727 WDR6 0.45 9.47 0.35 5.21e-20 Ulcerative colitis;Blood protein levels;Crohn's disease; BRCA cis rs1129187 0.755 rs2274514 chr6:42934500 C/T cg02353165 chr6:42928485 GNMT 0.76 18.78 0.6 5.32e-63 Alzheimer's disease in APOE e4+ carriers; BRCA trans rs6089829 0.962 rs1116450 chr20:61658210 T/C cg15934090 chr1:100435551 SLC35A3 0.35 7.93 0.3 9.76e-15 Prostate cancer (SNP x SNP interaction); BRCA cis rs898097 0.691 rs7222745 chr17:80907253 C/T cg15664640 chr17:80829946 TBCD -0.43 -11.6 -0.42 2.36e-28 Breast cancer; BRCA cis rs11229555 0.874 rs10896787 chr11:58285494 G/T cg15696309 chr11:58395628 NA -0.54 -11.47 -0.41 7.94e-28 Ulcerative colitis;Inflammatory bowel disease;Crohn's disease; BRCA cis rs812925 0.519 rs1186696 chr2:61660483 A/C cg15711740 chr2:61764176 XPO1 -0.33 -7.98 -0.3 6.78e-15 Immature fraction of reticulocytes; BRCA cis rs11711311 1.000 rs2305545 chr3:113499733 A/G cg15478005 chr3:113465772 ATP6V1A;NAA50 0.37 9.67 0.36 1.02e-20 IgG glycosylation; BRCA trans rs208520 0.690 rs3846808 chr6:66818604 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.0 -21.06 -0.64 3.5e-75 Exhaled nitric oxide output; BRCA cis rs72615157 0.645 rs76281814 chr7:99846414 T/C cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.6 9.05 0.34 1.69e-18 Lung function (FEV1/FVC); BRCA trans rs57221529 0.766 rs56350081 chr5:583198 G/A cg08313168 chr12:7315531 NA 0.5 7.98 0.3 6.91e-15 Lung disease severity in cystic fibrosis; BRCA cis rs6460942 1.000 rs117657017 chr7:12318891 T/C cg06484146 chr7:12443880 VWDE -0.62 -8.47 -0.32 1.69e-16 Coronary artery disease; BRCA cis rs2836974 0.932 rs13048178 chr21:40561012 G/T cg17971929 chr21:40555470 PSMG1 0.79 18.37 0.59 7.78e-61 Cognitive function; BRCA cis rs57590327 0.555 rs3772884 chr3:81802720 G/T cg07356753 chr3:81810745 GBE1 -0.44 -10.52 -0.38 5.75e-24 Extraversion; BRCA cis rs8180040 0.620 rs9875235 chr3:47083621 G/A cg27129171 chr3:47204927 SETD2 0.71 17.05 0.56 5.37e-54 Colorectal cancer; BRCA cis rs2836974 0.931 rs12151994 chr21:40690397 A/C cg11644478 chr21:40555479 PSMG1 0.84 18.75 0.6 8.13e-63 Cognitive function; BRCA cis rs11690935 0.959 rs2674484 chr2:172574612 G/A cg13550731 chr2:172543902 DYNC1I2 -0.93 -31.07 -0.78 7.64e-130 Schizophrenia; BRCA trans rs61931739 0.929 rs7955240 chr12:34066388 G/A cg26384229 chr12:38710491 ALG10B -0.43 -10.15 -0.37 1.58e-22 Morning vs. evening chronotype; BRCA cis rs2832191 1.000 rs8131214 chr21:30483386 T/G cg08807101 chr21:30365312 RNF160 -0.57 -14.02 -0.49 3.76e-39 Dental caries; BRCA cis rs7520050 0.966 rs6672898 chr1:46290588 G/A cg24296786 chr1:45957014 TESK2 0.44 9.9 0.36 1.38e-21 Red blood cell count;Reticulocyte count; BRCA cis rs6714710 0.603 rs4311104 chr2:98424802 A/G cg26665480 chr2:98280029 ACTR1B 0.58 13.62 0.47 2.86e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs887829 0.570 rs10168333 chr2:234596988 C/T cg26799339 chr2:234664336 UGT1A10;UGT1A6;UGT1A8;UGT1A4;UGT1A3;UGT1A9;UGT1A7;UGT1A5 -0.33 -8.36 -0.31 3.83e-16 Metabolic traits;Bilirubin levels;Cholelithiasis-related traits in sickle cell anemia;Metabolite levels;Total bilirubin levels in HIV-1 infection;Serum metabolite levels;Blood metabolite levels; BRCA trans rs2727020 0.521 rs10839285 chr11:49496852 T/G cg03929089 chr4:120376271 NA 0.7 14.24 0.49 3.5e-40 Coronary artery disease; BRCA cis rs10924970 0.625 rs12730441 chr1:235498059 G/T cg26050004 chr1:235667680 B3GALNT2 0.36 8.39 0.32 3.03e-16 Asthma; BRCA cis rs1008375 0.932 rs4698650 chr4:17692878 G/C cg04450456 chr4:17643702 FAM184B 0.32 9.35 0.35 1.44e-19 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11098499 0.754 rs1511017 chr4:120250805 G/A cg09307838 chr4:120376055 NA 0.64 14.08 0.49 1.96e-39 Corneal astigmatism; BRCA cis rs7918232 0.941 rs4749230 chr10:27441218 C/T cg14240646 chr10:27532245 ACBD5 -0.6 -9.29 -0.35 2.35e-19 Breast cancer; BRCA cis rs7666738 0.649 rs28865589 chr4:98954279 C/A cg05340658 chr4:99064831 C4orf37 0.67 16.38 0.54 1.38e-50 Colonoscopy-negative controls vs population controls; BRCA cis rs9790314 0.540 rs9844862 chr3:161076188 G/A cg03342759 chr3:160939853 NMD3 -0.56 -11.99 -0.43 4.87e-30 Morning vs. evening chronotype; BRCA cis rs4073582 0.595 rs1151540 chr11:66041807 A/C cg16950941 chr11:66035639 RAB1B 0.46 12.17 0.43 8.49e-31 Gout; BRCA trans rs1997103 1.000 rs2331064 chr7:55408610 C/G cg20935933 chr6:143382018 AIG1 0.6 11.61 0.42 2.11e-28 QRS interval (sulfonylurea treatment interaction); BRCA cis rs4481887 1.000 rs4474293 chr1:248470438 T/C cg00666640 chr1:248458726 OR2T12 0.32 8.83 0.33 9.7e-18 Common traits (Other); BRCA cis rs10465746 0.967 rs11163876 chr1:84440605 T/C cg10977910 chr1:84465055 TTLL7 0.51 10.36 0.38 2.4e-23 Obesity-related traits; BRCA cis rs2404602 0.735 rs4886805 chr15:76739384 A/G cg23625390 chr15:77176239 SCAPER 0.51 12.33 0.44 1.81e-31 Blood metabolite levels; BRCA cis rs2836974 0.931 rs2735306 chr21:40713134 A/G cg11644478 chr21:40555479 PSMG1 -0.76 -16.66 -0.55 5.06e-52 Cognitive function; BRCA cis rs12711979 0.765 rs6715805 chr2:3821117 T/C cg17052675 chr2:3827356 NA -0.48 -14.31 -0.49 1.8e-40 Itch intensity from mosquito bite adjusted by bite size; BRCA cis rs60871478 1.000 rs4721124 chr7:823761 T/C cg27478167 chr7:817139 HEATR2 -0.44 -9.55 -0.35 2.7e-20 Cerebrospinal P-tau181p levels; BRCA cis rs10089 0.953 rs72794400 chr5:127516028 C/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.62 14.22 0.49 4.38e-40 Ileal carcinoids; BRCA cis rs1448094 0.512 rs4540904 chr12:86235472 A/G cg19622623 chr12:86230825 RASSF9 -0.34 -9.42 -0.35 8.17e-20 Major depressive disorder; BRCA cis rs26949 0.504 rs10054744 chr5:60040047 C/G cg02684056 chr5:59996105 DEPDC1B -0.33 -7.87 -0.3 1.56e-14 Intelligence (multi-trait analysis); BRCA cis rs4665809 0.590 rs1469523 chr2:26474631 T/A cg08067268 chr2:26466485 HADHB;HADHA 0.57 9.81 0.36 3e-21 Gut microbiome composition (summer); BRCA cis rs12541635 0.966 rs2217391 chr8:107063126 A/G cg10147462 chr8:107024639 NA 0.35 9.71 0.36 7.11e-21 Age of smoking initiation; BRCA cis rs4665809 1.000 rs6729757 chr2:26285102 A/G cg26314531 chr2:26401878 FAM59B -0.66 -11.25 -0.41 6.63e-27 Gut microbiome composition (summer); BRCA cis rs3125734 0.534 rs10821973 chr10:64052337 G/A cg09941381 chr10:64027924 RTKN2 -0.29 -8.04 -0.3 4.43e-15 Rheumatoid arthritis; BRCA cis rs7647973 0.626 rs4855833 chr3:49657441 A/G cg03060546 chr3:49711283 APEH 0.56 9.84 0.36 2.26e-21 Menarche (age at onset); BRCA trans rs2832077 0.943 rs2832084 chr21:30154798 A/G cg14791747 chr16:20752902 THUMPD1 0.39 9.27 0.34 2.92e-19 Cognitive test performance; BRCA cis rs78456975 0.506 rs10167704 chr2:1571037 G/C cg01028140 chr2:1542097 TPO -0.58 -11.82 -0.42 2.63e-29 Placebo response in major depressive disorder (% change in symptom score); BRCA cis rs7666738 0.830 rs2865981 chr4:99031493 G/A cg17366294 chr4:99064904 C4orf37 0.46 11.02 0.4 5.61e-26 Colonoscopy-negative controls vs population controls; BRCA cis rs10992471 0.630 rs10992322 chr9:95159196 A/G cg14631576 chr9:95140430 CENPP -0.32 -8.07 -0.3 3.54e-15 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs7412746 0.658 rs2864869 chr1:150734655 G/A cg15448220 chr1:150897856 SETDB1 0.36 8.26 0.31 8.31e-16 Melanoma; BRCA cis rs4689592 0.513 rs3857177 chr4:7066332 G/A cg26116260 chr4:7069785 GRPEL1 0.95 27.85 0.74 2.18e-112 Monocyte percentage of white cells; BRCA cis rs7618915 0.501 rs7622694 chr3:52663882 G/A cg10802521 chr3:52805072 NEK4 -0.33 -9.12 -0.34 9.27e-19 Bipolar disorder; BRCA cis rs490234 0.902 rs10739663 chr9:128278739 A/G cg14078157 chr9:128172775 NA -0.33 -7.87 -0.3 1.55e-14 Mean arterial pressure; BRCA trans rs9329221 0.683 rs688491 chr8:9884823 C/G cg06636001 chr8:8085503 FLJ10661 -0.48 -10.23 -0.38 7.63e-23 Neuroticism; BRCA cis rs9646954 0.542 rs4149510 chr2:101023635 G/A cg08017756 chr2:100939284 LONRF2 -0.31 -7.97 -0.3 7.58e-15 Intelligence (multi-trait analysis); BRCA cis rs30380 1.000 rs30378 chr5:96121994 A/G cg16492584 chr5:96139282 ERAP1 -0.31 -7.95 -0.3 8.37e-15 Cerebrospinal fluid biomarker levels; BRCA trans rs7618501 0.633 rs11925192 chr3:50038664 G/A cg21659725 chr3:3221576 CRBN 0.42 10.37 0.38 2.2e-23 Intelligence (multi-trait analysis); BRCA cis rs7605378 1.000 rs10194076 chr2:200677663 T/C cg23649088 chr2:200775458 C2orf69 0.49 9.98 0.37 7.05e-22 Osteoporosis; BRCA cis rs4665809 0.590 rs4665315 chr2:26416036 T/G cg22920501 chr2:26401640 FAM59B -0.91 -16.04 -0.54 6.5e-49 Gut microbiome composition (summer); BRCA trans rs7647973 0.710 rs34890793 chr3:49619493 C/T cg21665057 chr3:196295764 WDR53;FBXO45 -0.45 -8.91 -0.33 5.2e-18 Menarche (age at onset); BRCA cis rs7824557 0.767 rs4559208 chr8:11153925 C/G cg21775007 chr8:11205619 TDH 0.61 12.17 0.43 8.35e-31 Retinal vascular caliber; BRCA cis rs6763687 0.637 rs747612 chr3:171822023 G/A cg16233210 chr3:171778391 FNDC3B 0.4 9.28 0.34 2.53e-19 Red cell distribution width; BRCA cis rs7809950 0.953 rs2520267 chr7:107187497 T/C cg23024343 chr7:107201750 COG5 -0.39 -8.96 -0.33 3.55e-18 Coronary artery disease; BRCA cis rs13256369 0.851 rs13267036 chr8:8566685 G/A cg17143192 chr8:8559678 CLDN23 0.55 10.39 0.38 1.79e-23 Obesity-related traits; BRCA cis rs6430585 0.528 rs7606267 chr2:136668123 T/C cg07169764 chr2:136633963 MCM6 1.27 26.71 0.73 3.86e-106 Corneal structure; BRCA cis rs838147 0.534 rs2638280 chr19:49209318 G/A cg21064579 chr19:49206444 FUT2 0.32 7.98 0.3 7.05e-15 Dietary macronutrient intake; BRCA cis rs17376456 0.825 rs10053405 chr5:93275403 A/G cg21475434 chr5:93447410 FAM172A -0.63 -7.9 -0.3 1.22e-14 Diabetic retinopathy; BRCA cis rs1129187 0.902 rs10948059 chr6:42928461 C/T cg21280719 chr6:42927975 GNMT -0.31 -12.81 -0.45 1.35e-33 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs597539 0.616 rs513476 chr11:68698996 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.77 18.14 0.58 1.24e-59 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs1165205 0.558 rs793144 chr6:25879321 C/T cg15691649 chr6:25882328 NA -0.45 -8.58 -0.32 7.41e-17 Urate levels; BRCA trans rs11098499 0.657 rs7664458 chr4:120371967 A/G cg19731845 chr4:166199412 KLHL2;GK3P 0.34 7.9 0.3 1.22e-14 Corneal astigmatism; BRCA cis rs9790314 0.631 rs9867582 chr3:160797405 A/G cg03342759 chr3:160939853 NMD3 -0.49 -10.06 -0.37 3.44e-22 Morning vs. evening chronotype; BRCA cis rs7917772 0.503 rs7899576 chr10:104307504 G/A cg11453585 chr10:104263688 ACTR1A;SUFU 0.62 18.4 0.59 5.58e-61 Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour);White blood cell count;Waist-to-hip ratio adjusted for body mass index; BRCA cis rs10504229 1.000 rs78953746 chr8:58170608 A/G cg22535103 chr8:58192502 C8orf71 -0.62 -13.34 -0.47 5.49e-36 Developmental language disorder (linguistic errors); BRCA cis rs2075371 1.000 rs2075372 chr7:133984432 C/T cg11752832 chr7:134001865 SLC35B4 0.53 13.77 0.48 5.95e-38 Mean platelet volume; BRCA cis rs2839186 0.609 rs2839189 chr21:47694357 C/T cg09417038 chr21:47716443 C21orf57 0.33 8.54 0.32 9.51e-17 Testicular germ cell tumor; BRCA trans rs1974653 0.781 rs4476436 chr22:20082961 T/C cg20152630 chr19:46405944 MYPOP 0.37 8.31 0.31 5.53e-16 Schizophrenia; BRCA cis rs735396 0.770 rs1169314 chr12:121443116 A/G cg02403541 chr12:121454288 C12orf43 0.64 12.33 0.44 1.75e-31 N-glycan levels; BRCA cis rs7131987 0.834 rs7139273 chr12:29434650 T/C cg09582351 chr12:29534625 ERGIC2 -0.42 -10.06 -0.37 3.5e-22 QT interval; BRCA cis rs10876993 0.928 rs1689596 chr12:58053029 T/C cg18357645 chr12:58087776 OS9 0.46 13.25 0.46 1.38e-35 Celiac disease or Rheumatoid arthritis; BRCA cis rs1552244 1.000 rs17032276 chr3:10076975 A/C cg13047869 chr3:10149882 C3orf24 0.58 12.2 0.43 6.43e-31 Alzheimer's disease; BRCA cis rs10479542 0.702 rs13183521 chr5:178975606 A/G cg22764044 chr5:178986830 RUFY1 -0.36 -9.4 -0.35 9.94e-20 Lung cancer; BRCA cis rs4665809 0.567 rs12999875 chr2:26414847 A/C cg26119090 chr2:26468346 HADHA;HADHB 1.06 22.11 0.66 6.54e-81 Gut microbiome composition (summer); BRCA cis rs1476670 0.710 rs751442 chr1:44509551 A/C cg09470012 chr1:44509516 NA 0.44 9.75 0.36 5.06e-21 Eotaxin levels; BRCA cis rs12477438 0.953 rs3851334 chr2:99794704 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.71 -13.12 -0.46 5.66e-35 Chronic sinus infection; BRCA cis rs6582630 0.502 rs11520261 chr12:38332019 T/G cg26384229 chr12:38710491 ALG10B 0.66 15.43 0.52 6.85e-46 Drug-induced liver injury (flucloxacillin); BRCA cis rs4820539 1.000 rs2267003 chr22:23457098 A/G cg14186256 chr22:23484241 RTDR1 0.73 21.27 0.64 2.55e-76 Bone mineral density; BRCA cis rs13118159 0.550 rs4974614 chr4:1373489 A/G cg19318889 chr4:1322082 MAEA 0.53 11.17 0.4 1.44e-26 Longevity; BRCA cis rs2836974 0.583 rs9636957 chr21:40705847 G/A cg17971929 chr21:40555470 PSMG1 -0.6 -13.25 -0.46 1.42e-35 Cognitive function; BRCA cis rs3741404 0.609 rs669913 chr11:63869879 A/G cg18225595 chr11:63971243 STIP1 0.4 9.91 0.37 1.2e-21 Platelet count; BRCA cis rs10751667 0.666 rs7395488 chr11:954111 T/C cg06064525 chr11:970664 AP2A2 -0.49 -16.27 -0.54 4.64e-50 Alzheimer's disease (late onset); BRCA cis rs13191362 1.000 rs13215491 chr6:163010325 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.82 12.93 0.46 3.84e-34 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs977987 0.806 rs1549306 chr16:75415341 A/G cg03315344 chr16:75512273 CHST6 0.54 12.95 0.46 3.26e-34 Dupuytren's disease; BRCA cis rs514406 0.644 rs6661196 chr1:53203664 A/G cg24675658 chr1:53192096 ZYG11B 0.63 14.98 0.51 1.02e-43 Monocyte count; BRCA cis rs1008375 1.000 rs10012335 chr4:17628630 C/G cg15017067 chr4:17643749 FAM184B 0.31 9.53 0.35 3.27e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6952808 0.594 rs3778964 chr7:2138109 C/T cg02951883 chr7:2050386 MAD1L1 -0.54 -12.21 -0.44 5.58e-31 Bipolar disorder and schizophrenia; BRCA cis rs13108904 0.875 rs1732099 chr4:1282696 T/C cg05665937 chr4:1216051 CTBP1 -0.4 -8.53 -0.32 1.06e-16 Obesity-related traits; BRCA cis rs875971 1.000 rs55962648 chr7:65625751 C/G cg12463550 chr7:65579703 CRCP -0.37 -8.04 -0.3 4.41e-15 Aortic root size; BRCA cis rs7493 1.000 rs6968305 chr7:95042529 G/A cg19678392 chr7:94953810 PON1 -0.43 -9.08 -0.34 1.38e-18 Yu-Zhi constitution type in type 2 diabetes; BRCA cis rs11098499 0.865 rs11098513 chr4:120316075 A/G cg09307838 chr4:120376055 NA 0.75 16.65 0.55 5.56e-52 Corneal astigmatism; BRCA cis rs1008375 1.000 rs28480159 chr4:17685707 A/C cg15017067 chr4:17643749 FAM184B 0.31 9.64 0.36 1.27e-20 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs8031584 0.918 rs1425292 chr15:31285422 G/A cg14829155 chr15:31115871 NA -0.44 -10.1 -0.37 2.42e-22 Huntington's disease progression; BRCA cis rs218264 0.592 rs34534202 chr4:55368913 C/G cg17105814 chr4:55365203 NA -0.4 -8.32 -0.31 5.41e-16 Hemoglobin concentration;Hematocrit; BRCA cis rs4566357 0.615 rs10198214 chr2:227913314 A/C cg11843606 chr2:227700838 RHBDD1 -0.42 -9.4 -0.35 9.56e-20 Coronary artery disease; BRCA cis rs72615157 0.613 rs56089143 chr7:99819844 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 0.7 13.1 0.46 6.81e-35 Lung function (FEV1/FVC); BRCA cis rs7811142 0.830 rs10085549 chr7:99983135 C/T cg23667466 chr7:100026434 MEPCE;ZCWPW1 0.83 14.94 0.51 1.73e-43 Platelet count; BRCA cis rs4665809 1.000 rs11126340 chr2:26253255 A/G cg27170947 chr2:26402098 FAM59B -0.63 -10.59 -0.39 2.84e-24 Gut microbiome composition (summer); BRCA cis rs12541635 0.677 rs4734892 chr8:106990088 G/C cg10147462 chr8:107024639 NA 0.4 10.42 0.38 1.34e-23 Age of smoking initiation; BRCA cis rs2404602 0.647 rs12439141 chr15:77095423 T/C cg23625390 chr15:77176239 SCAPER -0.55 -12.77 -0.45 1.92e-33 Blood metabolite levels; BRCA cis rs3799378 0.582 rs1796518 chr6:26388672 C/T cg09904177 chr6:26538194 HMGN4 -0.33 -8.23 -0.31 1.04e-15 Intelligence (multi-trait analysis); BRCA cis rs875971 0.522 rs4718285 chr7:65292005 A/G cg11764359 chr7:65958608 NA 0.62 13.65 0.48 1.99e-37 Aortic root size; BRCA cis rs6088590 0.648 rs6059991 chr20:33280836 C/T cg08999081 chr20:33150536 PIGU 0.44 11.95 0.43 7.25e-30 Coronary artery disease; BRCA cis rs2180341 0.814 rs6569488 chr6:127726256 C/T cg27446573 chr6:127587934 RNF146 0.69 15.82 0.53 8.25e-48 Breast cancer; BRCA cis rs780096 0.526 rs13472 chr2:27600239 G/A cg21248554 chr2:27665150 KRTCAP3 -0.32 -8.27 -0.31 7.98e-16 Total body bone mineral density; BRCA cis rs477895 0.653 rs11603212 chr11:63927810 C/T cg23719950 chr11:63933701 MACROD1 0.55 8.74 0.33 2.03e-17 Mean platelet volume; BRCA cis rs8114671 0.967 rs3746427 chr20:33730464 A/G cg24642439 chr20:33292090 TP53INP2 0.41 8.12 0.31 2.32e-15 Height; BRCA cis rs3733585 0.762 rs6449217 chr4:10009151 T/A cg00071950 chr4:10020882 SLC2A9 0.51 12.05 0.43 2.81e-30 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7085104 0.552 rs11191414 chr10:104601565 A/T cg04362960 chr10:104952993 NT5C2 0.39 9.31 0.35 2.05e-19 Immature fraction of reticulocytes;Schizophrenia; BRCA cis rs736408 0.608 rs35004449 chr3:52852897 G/T cg18404041 chr3:52824283 ITIH1 -0.39 -10.7 -0.39 1.09e-24 Bipolar disorder; BRCA cis rs763121 0.853 rs4821812 chr22:39075235 G/C cg14440974 chr22:39074834 NA -0.39 -9.17 -0.34 6.68e-19 Menopause (age at onset); BRCA cis rs7772486 0.875 rs9373485 chr6:146401429 A/T cg13319975 chr6:146136371 FBXO30 -0.38 -8.72 -0.33 2.43e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs1997103 1.000 rs2140915 chr7:55410699 G/C cg17469321 chr7:55412551 NA 0.5 9.63 0.36 1.41e-20 QRS interval (sulfonylurea treatment interaction); BRCA cis rs1595825 0.891 rs16824264 chr2:198675917 T/C cg19156104 chr2:198669113 PLCL1 -0.42 -7.97 -0.3 7.13e-15 Ulcerative colitis; BRCA cis rs6942756 1.000 rs6942756 chr7:128886821 T/G cg02491457 chr7:128862824 NA -0.72 -14.17 -0.49 8.16e-40 White matter hyperintensity burden; BRCA cis rs921968 0.565 rs6436081 chr2:219637884 A/G cg02176678 chr2:219576539 TTLL4 -0.42 -11.2 -0.41 1.02e-26 Mean corpuscular hemoglobin concentration; BRCA cis rs10193935 0.818 rs2374428 chr2:42667961 T/C cg27598129 chr2:42591480 NA 0.79 13.3 0.47 8.46e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs7666738 0.830 rs6811940 chr4:98777898 G/A cg17366294 chr4:99064904 C4orf37 0.42 9.71 0.36 6.85e-21 Colonoscopy-negative controls vs population controls; BRCA trans rs561341 1.000 rs4795667 chr17:30244443 T/C cg27661571 chr11:113659931 NA -0.76 -11.6 -0.42 2.29e-28 Hip circumference adjusted for BMI; BRCA cis rs13190036 1.000 rs13167431 chr5:176621075 G/C cg06733329 chr5:176740039 MXD3 0.46 8.22 0.31 1.12e-15 Neutrophil percentage of white cells;Lymphocyte percentage of white cells; BRCA cis rs4631830 0.720 rs113082846 chr10:51502802 G/C cg20129853 chr10:51489980 NA -0.32 -8.39 -0.32 3.07e-16 Prostate-specific antigen levels; BRCA cis rs10256972 0.591 rs10229680 chr7:1158565 C/T cg03923535 chr7:1197113 ZFAND2A 0.5 10.19 0.37 1.1e-22 Longevity;Endometriosis; BRCA cis rs2070488 0.574 rs57754356 chr3:38488706 C/G cg24069376 chr3:38537580 EXOG 0.32 9.06 0.34 1.6e-18 Electrocardiographic conduction measures; BRCA cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg11062466 chr8:58055876 NA 0.5 8.76 0.33 1.7e-17 Developmental language disorder (linguistic errors); BRCA cis rs4665809 0.877 rs34536218 chr2:26287376 T/A cg25036284 chr2:26402008 FAM59B 0.77 10.65 0.39 1.79e-24 Gut microbiome composition (summer); BRCA cis rs4727027 0.800 rs12530946 chr7:148887942 A/G cg12479418 chr7:148823350 ZNF425;ZNF398 0.44 9.01 0.34 2.41e-18 Eosinophil counts;Sum eosinophil basophil counts;Neutrophil percentage of granulocytes;Eosinophil percentage of granulocytes;Eosinophil percentage of white cells; BRCA cis rs875971 0.798 rs7789615 chr7:65878661 A/G cg11764359 chr7:65958608 NA 0.75 16.57 0.55 1.37e-51 Aortic root size; BRCA cis rs2288912 0.807 rs10423208 chr19:45453656 G/A cg09555818 chr19:45449301 APOC2 0.47 12.22 0.44 5.19e-31 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs9818758 0.607 rs61729488 chr3:49067904 T/C cg00383909 chr3:49044727 WDR6 0.99 15.08 0.51 3.48e-44 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs9420 0.961 rs708228 chr11:57585662 C/T cg19752551 chr11:57585705 CTNND1 -0.51 -12.56 -0.45 1.68e-32 Schizophrenia; BRCA trans rs4718428 0.705 rs28648401 chr7:66367132 T/C cg18876405 chr7:65276391 NA 0.43 8.45 0.32 1.96e-16 Corneal structure; BRCA cis rs7043114 0.525 rs7850432 chr9:95130510 G/A cg14631576 chr9:95140430 CENPP -0.34 -8.38 -0.31 3.32e-16 Height; BRCA cis rs3096299 0.658 rs34590044 chr16:89543157 A/C cg06640241 chr16:89574553 SPG7 0.8 19.79 0.62 2.32e-68 Multiple myeloma (IgH translocation); BRCA cis rs10503871 0.685 rs7824823 chr8:30322735 G/T cg26383811 chr8:30366931 RBPMS -0.32 -8.76 -0.33 1.7e-17 Metabolite levels (X-11787); BRCA cis rs12701220 0.895 rs12534778 chr7:1065861 C/T cg00990874 chr7:1149470 C7orf50 0.53 9.81 0.36 2.93e-21 Bronchopulmonary dysplasia; BRCA trans rs7395662 0.526 rs4882001 chr11:48546675 A/G cg03929089 chr4:120376271 NA -0.46 -9.29 -0.34 2.4e-19 HDL cholesterol; BRCA cis rs17095355 0.579 rs72828224 chr10:111702047 A/G cg00817464 chr10:111662876 XPNPEP1 -0.38 -9.97 -0.37 7.39e-22 Biliary atresia; BRCA cis rs1707322 0.663 rs3935296 chr1:46180470 T/C cg03146154 chr1:46216737 IPP -0.54 -12.02 -0.43 3.92e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7246657 0.943 rs7253091 chr19:37967214 C/T cg14683738 chr19:37701593 ZNF585B 0.44 7.91 0.3 1.14e-14 Coronary artery calcification; BRCA cis rs59918340 0.616 rs3739222 chr8:142205904 C/G cg23750338 chr8:142222470 SLC45A4 0.41 10.13 0.37 1.84e-22 Immature fraction of reticulocytes; BRCA cis rs1348850 0.567 rs4893838 chr2:178531436 T/C cg22681709 chr2:178499509 PDE11A -0.41 -8.86 -0.33 7.65e-18 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs9291683 0.609 rs4622999 chr4:10003395 C/G cg02734326 chr4:10020555 SLC2A9 0.37 8.13 0.31 2.3e-15 Bone mineral density; BRCA cis rs1355223 0.583 rs1549789 chr11:34867947 G/A cg24088639 chr11:34937564 PDHX;APIP -0.41 -9.12 -0.34 9.28e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs7520050 0.807 rs12025621 chr1:46228391 G/A cg24296786 chr1:45957014 TESK2 0.45 10.35 0.38 2.6e-23 Red blood cell count;Reticulocyte count; BRCA cis rs713587 0.607 rs6725517 chr2:25129473 A/G cg04586622 chr2:25135609 ADCY3 0.47 11.89 0.43 1.4e-29 Body mass index in non-asthmatics; BRCA cis rs7618915 0.571 rs12487445 chr3:52618319 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.35 11.1 0.4 2.62e-26 Bipolar disorder; BRCA cis rs875971 0.522 rs1880556 chr7:65432544 T/C cg18876405 chr7:65276391 NA 0.68 17.92 0.58 1.82e-58 Aortic root size; BRCA cis rs1008375 0.806 rs13139898 chr4:17706928 T/G cg04450456 chr4:17643702 FAM184B -0.3 -8.5 -0.32 1.38e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs6762 0.719 rs28655651 chr11:837121 G/C cg15787769 chr11:842744 TSPAN4;POLR2L -0.57 -13.22 -0.46 1.9e-35 Mean platelet volume; BRCA cis rs2050392 0.517 rs160017 chr10:30772894 A/G cg18806716 chr10:30721971 MAP3K8 -0.41 -9.51 -0.35 3.81e-20 Inflammatory bowel disease; BRCA cis rs7044106 0.762 rs966396 chr9:123453281 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.66 14.3 0.49 1.81e-40 Hip circumference adjusted for BMI; BRCA cis rs9814567 1.000 rs1814337 chr3:134200682 C/T cg06109529 chr3:134205091 CEP63;ANAPC13 -0.58 -19.14 -0.6 6.81e-65 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs3008870 0.629 rs12742428 chr1:67426487 A/G cg08660285 chr1:67390436 MIER1;WDR78 0.64 13.99 0.48 5.47e-39 Lymphocyte percentage of white cells; BRCA cis rs56104184 0.775 rs56146968 chr19:49398847 A/G cg21252483 chr19:49399788 TULP2 -0.5 -10.68 -0.39 1.26e-24 Reticulocyte fraction of red cells;Reticulocyte count;High light scatter reticulocyte percentage of red cells;High light scatter reticulocyte count; BRCA cis rs3858526 0.883 rs11039584 chr11:5935251 C/G cg02574844 chr11:5959923 NA -0.4 -8.05 -0.3 4.19e-15 DNA methylation (variation); BRCA cis rs1862618 0.853 rs1833896 chr5:56097669 C/A cg18230493 chr5:56204884 C5orf35 -0.68 -13.41 -0.47 2.57e-36 Initial pursuit acceleration; BRCA cis rs11955398 0.716 rs1379114 chr5:59997798 A/G cg02684056 chr5:59996105 DEPDC1B 0.39 9.35 0.35 1.42e-19 Intelligence (multi-trait analysis); BRCA cis rs6687430 0.526 rs12127400 chr1:10613660 C/T cg17425144 chr1:10567563 PEX14 0.57 13.36 0.47 4.64e-36 Hand grip strength; BRCA cis rs1552244 1.000 rs35220123 chr3:10083169 C/T cg13047869 chr3:10149882 C3orf24 0.59 12.55 0.44 1.94e-32 Alzheimer's disease; BRCA cis rs6570726 0.791 rs11155435 chr6:145938545 T/C cg23711669 chr6:146136114 FBXO30 0.78 18.44 0.59 3.27e-61 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 0.721 rs10890343 chr1:46157922 C/T cg24296786 chr1:45957014 TESK2 -0.39 -8.01 -0.3 5.38e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7523050 0.643 rs12741194 chr1:109400390 T/C cg08274380 chr1:109419600 GPSM2 0.98 13.97 0.48 7.02e-39 Fat distribution (HIV); BRCA cis rs9392556 0.829 rs649725 chr6:4109593 A/C cg08342332 chr6:4079704 C6orf201;C6orf146 0.37 8.16 0.31 1.84e-15 Blood metabolite levels; BRCA cis rs208520 0.690 rs851459 chr6:66813989 A/G cg07460842 chr6:66804631 NA -1.0 -19.98 -0.62 2.38e-69 Exhaled nitric oxide output; BRCA cis rs9611565 0.659 rs4822036 chr22:41936019 A/G cg06634786 chr22:41940651 POLR3H -0.59 -10.44 -0.38 1.12e-23 Vitiligo; BRCA cis rs4563143 0.704 rs16961809 chr19:29226299 C/T cg03161606 chr19:29218774 NA 0.45 8.18 0.31 1.57e-15 Methadone dose in opioid dependence; BRCA cis rs2576037 0.526 rs2571024 chr18:44557877 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.38 -9.44 -0.35 6.86e-20 Personality dimensions; BRCA cis rs1552244 1.000 rs6793396 chr3:10110927 T/C cg02579736 chr3:10068473 FANCD2;CIDECP 0.95 18.86 0.6 2.15e-63 Alzheimer's disease; BRCA cis rs9420 1.000 rs543725 chr11:57483039 A/T cg19752551 chr11:57585705 CTNND1 -0.42 -10.74 -0.39 7.56e-25 Schizophrenia; BRCA cis rs2985684 0.802 rs10150823 chr14:50051751 C/T cg04989706 chr14:50066350 PPIL5 -0.47 -9.21 -0.34 4.76e-19 Carotid intima media thickness; BRCA cis rs704795 0.867 rs7566052 chr2:27628635 A/G cg12648201 chr2:27665141 KRTCAP3 -0.34 -8.37 -0.31 3.51e-16 Menopause (age at onset); BRCA cis rs10193935 0.901 rs10169971 chr2:42602189 G/A cg27598129 chr2:42591480 NA -0.97 -15.46 -0.52 4.85e-46 Colonoscopy-negative controls vs population controls; BRCA cis rs10193935 0.901 rs12619348 chr2:42625586 C/T cg27598129 chr2:42591480 NA -0.8 -13.32 -0.47 6.82e-36 Colonoscopy-negative controls vs population controls; BRCA cis rs1707322 0.686 rs2991979 chr1:46055858 A/G cg06784218 chr1:46089804 CCDC17 -0.52 -12.42 -0.44 7.05e-32 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10911232 0.507 rs10797817 chr1:182999136 G/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.77 0.55 1.34e-52 Hypertriglyceridemia; BRCA trans rs459571 0.959 rs461462 chr9:136911272 C/T cg09836344 chr4:1243392 C4orf42;CTBP1 -0.73 -14.62 -0.5 5.64e-42 Platelet distribution width; BRCA cis rs7618915 0.501 rs12486554 chr3:52742537 A/T cg05573699 chr3:52720067 GNL3;PBRM1 -0.34 -7.94 -0.3 8.82e-15 Bipolar disorder; BRCA cis rs798554 0.757 rs1182177 chr7:2874540 C/T cg19346786 chr7:2764209 NA -0.31 -8.95 -0.33 3.94e-18 Height; BRCA cis rs7927771 0.524 rs4752860 chr11:47705015 C/A cg20307385 chr11:47447363 PSMC3 -0.39 -9.06 -0.34 1.57e-18 Subjective well-being; BRCA cis rs9348729 1 rs9348729 chr6:26664268 T/C cg12826209 chr6:26865740 GUSBL1 0.58 10.45 0.38 1.03e-23 Intelligence (multi-trait analysis); BRCA cis rs17270561 0.609 rs9379788 chr6:25742759 A/C cg17691542 chr6:26056736 HIST1H1C 0.45 8.73 0.33 2.17e-17 Iron status biomarkers; BRCA cis rs769267 0.965 rs7254230 chr19:19434350 C/T cg19010396 chr19:19431384 KIAA0892;SF4 -0.49 -9.93 -0.37 1.07e-21 Tonsillectomy; BRCA cis rs3824344 0.507 rs10814501 chr9:37019304 C/T cg14294708 chr9:37120828 ZCCHC7 0.42 8.56 0.32 8.24e-17 Intelligence; BRCA cis rs2276314 0.857 rs28375959 chr18:33601534 T/G cg19628046 chr18:33552617 C18orf21 0.55 10.58 0.39 3.18e-24 Endometriosis;Drug-induced torsades de pointes; BRCA cis rs1008375 0.966 rs6449330 chr4:17703949 C/T cg16339924 chr4:17578868 LAP3 -0.55 -13.59 -0.47 3.81e-37 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs11971779 0.774 rs6467838 chr7:139043501 A/G cg07862535 chr7:139043722 LUC7L2 0.38 10.37 0.38 2.13e-23 Diisocyanate-induced asthma; BRCA cis rs780096 0.526 rs1260341 chr2:27663215 T/A cg12648201 chr2:27665141 KRTCAP3 -0.36 -8.84 -0.33 9.56e-18 Total body bone mineral density; BRCA trans rs6952808 1.000 rs10260585 chr7:1889521 G/A cg04565464 chr8:145669602 NFKBIL2 0.37 8.17 0.31 1.71e-15 Bipolar disorder and schizophrenia; BRCA cis rs7811142 0.830 rs6965458 chr7:99973402 G/A cg00814883 chr7:100076585 TSC22D4 -0.49 -9.61 -0.36 1.69e-20 Platelet count; BRCA cis rs4237845 1.000 rs4237845 chr12:58302436 A/G cg00677455 chr12:58241039 CTDSP2 -0.44 -10.15 -0.37 1.58e-22 Intelligence (multi-trait analysis); BRCA trans rs6561151 0.681 rs17065161 chr13:44443723 A/T cg12856521 chr11:46389249 DGKZ 0.56 10.52 0.38 5.62e-24 Crohn's disease; BRCA cis rs16854884 0.657 rs4611822 chr3:143735544 C/T cg06585982 chr3:143692056 C3orf58 0.43 9.01 0.34 2.29e-18 Economic and political preferences (feminism/equality); BRCA cis rs1862618 0.853 rs6450408 chr5:56098146 T/C cg24549020 chr5:56110836 MAP3K1 0.65 13.07 0.46 9.15e-35 Initial pursuit acceleration; BRCA trans rs911555 0.692 rs7145753 chr14:103866100 G/A cg17675199 chr6:35436792 RPL10A -0.29 -7.93 -0.3 9.46e-15 Intelligence (multi-trait analysis); BRCA cis rs10992471 0.528 rs1924244 chr9:95224952 A/G cg14631576 chr9:95140430 CENPP -0.35 -8.67 -0.32 3.6e-17 Visceral adipose tissue/subcutaneous adipose tissue ratio; BRCA cis rs2180341 0.782 rs4897214 chr6:127723625 G/T cg27446573 chr6:127587934 RNF146 0.68 15.54 0.52 1.94e-46 Breast cancer; BRCA cis rs4319547 0.695 rs7969429 chr12:122875606 A/G cg05707623 chr12:122985044 ZCCHC8 -0.48 -9.34 -0.35 1.63e-19 Body mass index; BRCA cis rs13046373 0.535 rs13051135 chr21:32005278 G/A cg06468780 chr21:31798236 KRTAP13-3 0.33 8.32 0.31 5.43e-16 HDL cholesterol; BRCA cis rs7267979 1.000 rs6107046 chr20:25442049 G/A cg08601574 chr20:25228251 PYGB 0.36 8.37 0.31 3.65e-16 Liver enzyme levels (alkaline phosphatase); BRCA cis rs921968 0.565 rs1554622 chr2:219606218 T/G cg02176678 chr2:219576539 TTLL4 -0.42 -11.23 -0.41 7.69e-27 Mean corpuscular hemoglobin concentration; BRCA cis rs561341 1.000 rs4795667 chr17:30244443 T/C cg00745463 chr17:30367425 LRRC37B -0.56 -9.29 -0.34 2.36e-19 Hip circumference adjusted for BMI; BRCA cis rs12893668 0.572 rs7148857 chr14:104143237 C/G cg01849466 chr14:104193079 ZFYVE21 -0.46 -10.28 -0.38 4.93e-23 Reticulocyte count; BRCA cis rs870825 0.929 rs72689256 chr4:185590174 C/T cg04058563 chr4:185651563 MLF1IP 0.69 11.83 0.42 2.39e-29 Blood protein levels; BRCA cis rs780096 0.565 rs813592 chr2:27721971 T/C cg12000995 chr2:27665139 KRTCAP3 -0.34 -8.61 -0.32 5.53e-17 Total body bone mineral density; BRCA cis rs1153858 1.000 rs56806728 chr15:45637814 A/G cg14582100 chr15:45693742 SPATA5L1 0.36 11.85 0.42 1.99e-29 Homoarginine levels; BRCA trans rs6089829 0.855 rs6090205 chr20:61665269 A/G cg23505145 chr19:12996616 KLF1 0.54 12.33 0.44 1.69e-31 Prostate cancer (SNP x SNP interaction); BRCA cis rs12926788 0.689 rs1862450 chr16:24856775 A/G cg04756594 chr16:24857601 SLC5A11 -0.44 -8.44 -0.32 2.13e-16 Ejection fraction in Tripanosoma cruzi seropositivity; BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg03709012 chr19:19516395 GATAD2A 0.71 15.15 0.51 1.54e-44 Tonsillectomy; BRCA cis rs751728 0.638 rs4713686 chr6:33787506 C/T cg25922239 chr6:33757077 LEMD2 0.45 10.05 0.37 3.65e-22 Crohn's disease; BRCA cis rs763014 0.932 rs34498660 chr16:666149 A/G cg00908189 chr16:619842 PIGQ 0.7 17.63 0.57 5.55e-57 Height; BRCA cis rs666930 0.967 rs637868 chr1:120257110 A/G cg19096424 chr1:120255104 PHGDH 0.37 8.69 0.33 3.06e-17 Breast cancer; BRCA cis rs4665809 0.567 rs6546848 chr2:26444414 G/C cg08067268 chr2:26466485 HADHB;HADHA -0.57 -10.18 -0.37 1.13e-22 Gut microbiome composition (summer); BRCA cis rs2836974 0.965 rs9941894 chr21:40634058 C/T cg17971929 chr21:40555470 PSMG1 0.77 16.61 0.55 9.04e-52 Cognitive function; BRCA cis rs9311474 0.508 rs6786919 chr3:52599789 A/G cg18404041 chr3:52824283 ITIH1 -0.37 -11.3 -0.41 4.19e-27 Electroencephalogram traits; BRCA cis rs1552244 0.572 rs17032426 chr3:10167112 G/A cg13047869 chr3:10149882 C3orf24 0.57 10.45 0.38 1.05e-23 Alzheimer's disease; BRCA cis rs6088590 0.930 rs6120723 chr20:33364655 C/T cg08999081 chr20:33150536 PIGU 0.35 9.08 0.34 1.31e-18 Coronary artery disease; BRCA cis rs919433 0.679 rs55656916 chr2:198519628 T/C cg00792783 chr2:198669748 PLCL1 0.41 9.05 0.34 1.76e-18 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs765787 0.530 rs2433228 chr15:45515371 A/C cg24006582 chr15:45444508 DUOX1 -0.55 -11.31 -0.41 3.61e-27 Uric acid levels; BRCA cis rs72781680 1.000 rs7588286 chr2:24071427 A/G cg08917208 chr2:24149416 ATAD2B 0.93 13.64 0.47 2.22e-37 Lymphocyte counts; BRCA cis rs881375 0.967 rs2416805 chr9:123676482 T/C cg09419670 chr9:123605666 PSMD5;LOC253039 0.51 10.66 0.39 1.6e-24 Rheumatoid arthritis; BRCA trans rs208520 0.690 rs12194057 chr6:66745616 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.99 20.76 0.63 1.49e-73 Exhaled nitric oxide output; BRCA trans rs1005277 0.579 rs2474569 chr10:38383491 C/G cg17830980 chr10:43048298 ZNF37B -0.57 -13.86 -0.48 2.11e-38 Extrinsic epigenetic age acceleration; BRCA cis rs7666738 0.830 rs10049985 chr4:99023517 C/T cg03676636 chr4:99064102 C4orf37 0.21 8.0 0.3 5.69e-15 Colonoscopy-negative controls vs population controls; BRCA cis rs7572733 0.534 rs700662 chr2:198668751 T/C cg00792783 chr2:198669748 PLCL1 0.47 10.32 0.38 3.34e-23 Dermatomyositis; BRCA cis rs12477438 0.501 rs12619780 chr2:99707307 C/T cg14399236 chr2:99771627 LIPT1;TSGA10 0.77 21.47 0.65 2.06e-77 Chronic sinus infection; BRCA cis rs8177253 0.965 rs8177260 chr3:133480458 T/A cg11941060 chr3:133502564 NA -0.51 -12.4 -0.44 8.56e-32 Iron status biomarkers; BRCA cis rs910316 0.934 rs8006587 chr14:75664939 A/G cg08847533 chr14:75593920 NEK9 0.84 21.44 0.65 3.24e-77 Height; BRCA cis rs13108904 0.521 rs4974609 chr4:1356924 A/C cg16405210 chr4:1374714 KIAA1530 0.44 9.94 0.37 9.57e-22 Obesity-related traits; BRCA trans rs11098499 0.779 rs7356491 chr4:120381974 C/T cg19731845 chr4:166199412 KLHL2;GK3P 0.33 7.81 0.3 2.3e-14 Corneal astigmatism; BRCA cis rs911119 0.913 rs6048923 chr20:23578206 C/T cg16589663 chr20:23618590 CST3 0.43 7.88 0.3 1.43e-14 Chronic kidney disease; BRCA cis rs10504229 0.683 rs56192850 chr8:58135356 A/G cg11062466 chr8:58055876 NA 0.41 7.97 0.3 7.11e-15 Developmental language disorder (linguistic errors); BRCA cis rs6723226 1.000 rs6723226 chr2:32849207 C/T cg02381751 chr2:32503542 YIPF4 0.46 9.54 0.35 2.87e-20 Intelligence (multi-trait analysis); BRCA cis rs644799 0.965 rs11021305 chr11:95498269 A/G cg25478527 chr11:95522999 CEP57;FAM76B 0.47 9.92 0.37 1.1e-21 Intelligence (multi-trait analysis);Cognitive ability (multi-trait analysis); BRCA cis rs9337951 0.636 rs2487928 chr10:30323892 C/T cg00730780 chr10:30316187 KIAA1462 -0.44 -9.39 -0.35 1.01e-19 Pulse pressure;Coronary artery disease; BRCA cis rs9517320 0.534 rs3858776 chr13:99161457 C/T cg07423050 chr13:99094983 FARP1 -0.43 -10.43 -0.38 1.22e-23 Longevity; BRCA trans rs9388451 0.626 rs3734637 chr6:126081319 G/T cg05039488 chr6:79577232 IRAK1BP1 -0.56 -14.04 -0.49 3.23e-39 Brugada syndrome; BRCA cis rs12477438 0.765 rs7591794 chr2:99567514 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.58 -12.87 -0.45 7.32e-34 Chronic sinus infection; BRCA cis rs7124681 0.584 rs4752792 chr11:47815702 G/A cg20307385 chr11:47447363 PSMC3 -0.4 -9.37 -0.35 1.18e-19 Body mass index (joint analysis main effects and physical activity interaction);Body mass index;Body mass index in physically active individuals; BRCA cis rs2839186 0.770 rs2839171 chr21:47673247 C/T cg13732083 chr21:47605072 C21orf56 -0.37 -7.87 -0.3 1.54e-14 Testicular germ cell tumor; BRCA cis rs13191362 1.000 rs35424047 chr6:163029715 T/C cg06582575 chr6:163149167 PACRG;PARK2 0.81 12.49 0.44 3.53e-32 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs13108904 0.901 rs6826029 chr4:1307689 A/G cg05665937 chr4:1216051 CTBP1 0.37 7.9 0.3 1.19e-14 Obesity-related traits; BRCA cis rs372883 0.600 rs1312254 chr21:30695401 A/G cg24692254 chr21:30365293 RNF160 -0.5 -11.01 -0.4 6.14e-26 Pancreatic cancer; BRCA cis rs1129187 0.755 rs7760250 chr6:42929839 G/A cg16590910 chr6:42928470 GNMT 0.36 7.84 0.3 1.94e-14 Alzheimer's disease in APOE e4+ carriers; BRCA cis rs2739330 0.796 rs5760106 chr22:24250645 A/C cg23131131 chr22:24373011 LOC391322 0.45 10.44 0.38 1.12e-23 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs9944715 0.954 rs9807157 chr18:43817755 T/C cg01718231 chr17:29326311 RNF135 -0.46 -9.07 -0.34 1.51e-18 Red cell distribution width;Mean corpuscular volume; BRCA cis rs12291225 0.679 rs11605531 chr11:14291594 A/G cg19336497 chr11:14380999 RRAS2 -0.48 -11.96 -0.43 6.84e-30 Sense of smell; BRCA cis rs711245 0.518 rs11886145 chr2:36825716 C/G cg15105969 chr2:36825350 FEZ2 0.45 8.56 0.32 8.69e-17 Height; BRCA cis rs7666738 0.830 rs9992639 chr4:98940400 G/T cg17366294 chr4:99064904 C4orf37 0.44 10.36 0.38 2.29e-23 Colonoscopy-negative controls vs population controls; BRCA cis rs8114671 0.967 rs2378337 chr20:33771435 G/A cg07148914 chr20:33460835 GGT7 0.38 8.01 0.3 5.27e-15 Height; BRCA cis rs9290065 0.519 rs1562465 chr3:160701442 G/A cg03342759 chr3:160939853 NMD3 -0.49 -9.95 -0.37 9.17e-22 Kawasaki disease; BRCA trans rs783540 0.542 rs62009945 chr15:83299956 T/A cg18393722 chr15:85113863 UBE2QP1 -0.32 -8.12 -0.31 2.42e-15 Schizophrenia; BRCA cis rs17253792 0.915 rs28663681 chr14:56178820 A/T cg01858014 chr14:56050164 KTN1 -0.68 -8.53 -0.32 1.02e-16 Putamen volume; BRCA cis rs2836974 0.584 rs6517535 chr21:40653352 G/C cg11644478 chr21:40555479 PSMG1 -0.68 -15.35 -0.52 1.74e-45 Cognitive function; BRCA cis rs6714710 0.603 rs7583868 chr2:98588372 C/A cg26665480 chr2:98280029 ACTR1B 0.59 13.66 0.48 1.89e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7474896 0.537 rs2749589 chr10:38266870 C/T cg25427524 chr10:38739819 LOC399744 0.51 9.28 0.34 2.55e-19 Obesity (extreme); BRCA cis rs1707322 0.827 rs10890347 chr1:46242332 A/T cg03146154 chr1:46216737 IPP -0.51 -11.06 -0.4 3.95e-26 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs4595586 0.545 rs969468 chr12:39367278 A/C cg26384229 chr12:38710491 ALG10B 0.42 9.33 0.35 1.73e-19 Morning vs. evening chronotype; BRCA cis rs17376456 0.877 rs34184666 chr5:93444584 T/C cg25358565 chr5:93447407 FAM172A 1.21 19.73 0.62 5.16e-68 Diabetic retinopathy; BRCA cis rs7592578 0.771 rs4439990 chr2:191398353 A/C cg10560079 chr2:191398806 TMEM194B -0.74 -13.55 -0.47 6.03e-37 Diastolic blood pressure; BRCA cis rs8180040 0.654 rs4682831 chr3:47027138 A/G cg02527881 chr3:46936655 PTH1R 0.36 9.05 0.34 1.77e-18 Colorectal cancer; BRCA cis rs758324 0.947 rs58016983 chr5:131235275 T/C cg06307176 chr5:131281290 NA -0.57 -11.98 -0.43 5.62e-30 Alzheimer's disease in APOE e4- carriers; BRCA cis rs9487051 0.646 rs11153165 chr6:109622159 G/A cg01475377 chr6:109611718 NA -0.4 -8.85 -0.33 8.5e-18 Reticulocyte fraction of red cells; BRCA cis rs9527 0.590 rs12355120 chr10:104852166 T/G cg04362960 chr10:104952993 NT5C2 0.45 10.6 0.39 2.68e-24 Arsenic metabolism; BRCA cis rs921968 0.540 rs10190250 chr2:219457731 C/T cg02176678 chr2:219576539 TTLL4 -0.52 -13.23 -0.46 1.77e-35 Mean corpuscular hemoglobin concentration; BRCA cis rs60871478 0.545 rs35400476 chr7:795686 A/G cg04727924 chr7:799746 HEATR2 -0.54 -10.74 -0.39 7.86e-25 Cerebrospinal P-tau181p levels; BRCA cis rs35995292 0.517 rs6948026 chr7:38920854 A/G cg19327137 chr7:38886074 VPS41 0.38 12.68 0.45 4.91e-33 Subjective well-being (multi-trait analysis); BRCA cis rs1568889 1.000 rs11604085 chr11:28141002 G/A cg06544937 chr11:28130018 METT5D1;KIF18A 0.64 13.49 0.47 1.18e-36 Bipolar disorder; BRCA cis rs17270561 0.585 rs9393663 chr6:25741033 A/T cg17691542 chr6:26056736 HIST1H1C 0.45 8.72 0.33 2.35e-17 Iron status biomarkers; BRCA cis rs3820928 0.605 rs4675124 chr2:227802354 G/A cg11843606 chr2:227700838 RHBDD1 -0.5 -11.46 -0.41 8.4e-28 Pulmonary function; BRCA cis rs10751667 0.643 rs10902237 chr11:944801 C/A cg01483505 chr11:975446 AP2A2 0.3 8.17 0.31 1.61e-15 Alzheimer's disease (late onset); BRCA cis rs3845702 0.736 rs6722147 chr2:180829704 G/A cg01881094 chr2:180872142 CWC22 -1.02 -17.15 -0.56 1.67e-54 Schizophrenia; BRCA cis rs72781680 0.898 rs2339851 chr2:23938883 G/A cg20701182 chr2:24300061 SF3B14 0.63 8.92 0.33 4.85e-18 Lymphocyte counts; BRCA trans rs9467711 0.659 rs34246779 chr6:26549212 G/A cg01620082 chr3:125678407 NA -0.69 -8.53 -0.32 1.04e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs7666738 0.546 rs13148080 chr4:98680947 A/G cg05340658 chr4:99064831 C4orf37 0.58 11.24 0.41 7.41e-27 Colonoscopy-negative controls vs population controls; BRCA cis rs10193935 0.901 rs9789740 chr2:42486799 A/G cg27598129 chr2:42591480 NA -0.94 -14.7 -0.5 2.32e-42 Colonoscopy-negative controls vs population controls; BRCA cis rs6910061 0.830 rs13214911 chr6:11103690 C/A cg27233058 chr6:11094804 LOC221710 0.51 8.54 0.32 1.01e-16 Diabetic kidney disease; BRCA cis rs919433 0.680 rs3792159 chr2:198403697 A/G cg00792783 chr2:198669748 PLCL1 -0.37 -8.34 -0.31 4.59e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs1113500 0.965 rs10881495 chr1:108610986 C/A cg06207961 chr1:108661230 NA 0.44 10.4 0.38 1.69e-23 Growth-regulated protein alpha levels; BRCA cis rs9859260 0.744 rs419059 chr3:195782184 C/T cg03462622 chr3:195777018 TFRC -0.38 -8.61 -0.32 5.5e-17 Mean corpuscular volume; BRCA cis rs7589728 1.000 rs75181745 chr2:88520408 C/T cg07952391 chr2:88470173 THNSL2 0.58 8.06 0.3 3.84e-15 Plasma clusterin levels; BRCA cis rs36051895 0.659 rs2149555 chr9:5053743 C/T cg02405213 chr9:5042618 JAK2 -0.52 -9.54 -0.35 3e-20 Pediatric autoimmune diseases; BRCA cis rs10046574 0.831 rs76054058 chr7:135093486 G/C cg27474649 chr7:135195673 CNOT4 0.59 8.29 0.31 6.82e-16 Peripheral arterial disease (traffic-related air pollution interaction); BRCA trans rs11098499 0.754 rs34425882 chr4:120253177 G/A cg25214090 chr10:38739885 LOC399744 0.45 10.28 0.38 4.83e-23 Corneal astigmatism; BRCA cis rs769267 0.895 rs2315279 chr19:19479936 C/A cg03709012 chr19:19516395 GATAD2A -0.8 -18.5 -0.59 1.68e-61 Tonsillectomy; BRCA cis rs17253792 0.732 rs10146604 chr14:56045770 C/G cg24579896 chr14:56047964 C14orf33;KTN1 0.61 8.47 0.32 1.71e-16 Putamen volume; BRCA cis rs6951245 0.638 rs74976697 chr7:1160505 C/T cg23708337 chr7:1209742 NA 0.7 11.05 0.4 4.23e-26 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs208520 0.565 rs1385222 chr6:66753013 C/T cg07460842 chr6:66804631 NA 0.99 26.66 0.73 7.26e-106 Exhaled nitric oxide output; BRCA cis rs7095944 0.614 rs10901817 chr10:126443404 A/T cg08799069 chr10:126477246 METTL10 -0.4 -9.49 -0.35 4.41e-20 Asthma; BRCA cis rs7246657 0.943 rs7255952 chr19:37988797 A/G cg18154014 chr19:37997991 ZNF793 0.57 11.25 0.41 6.39e-27 Coronary artery calcification; BRCA cis rs12618769 0.652 rs72821965 chr2:99188783 T/C cg10123293 chr2:99228465 UNC50 0.42 8.52 0.32 1.19e-16 Bipolar disorder; BRCA cis rs1552244 0.872 rs115331527 chr3:10154504 G/A cg00166722 chr3:10149974 C3orf24 0.66 13.21 0.46 2.15e-35 Alzheimer's disease; BRCA cis rs2637266 0.967 rs12246436 chr10:78352914 C/T cg18941641 chr10:78392320 NA 0.35 7.81 0.3 2.29e-14 Pulmonary function; BRCA cis rs7647973 0.580 rs7652746 chr3:49262307 C/T cg07636037 chr3:49044803 WDR6 -0.79 -20.43 -0.63 8.72e-72 Menarche (age at onset); BRCA cis rs9868809 0.505 rs28793701 chr3:48762683 C/G cg03060546 chr3:49711283 APEH -0.57 -7.85 -0.3 1.79e-14 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs10751667 0.666 rs7396473 chr11:966181 T/C ch.11.42038R chr11:967971 AP2A2 0.52 16.51 0.55 2.86e-51 Alzheimer's disease (late onset); BRCA cis rs2880765 0.835 rs4514633 chr15:86041017 T/G cg10818794 chr15:86012489 AKAP13 -0.3 -8.43 -0.32 2.36e-16 Coronary artery disease; BRCA cis rs79839061 0.610 rs11248051 chr4:858332 C/T cg07828340 chr4:882639 GAK 1.03 12.29 0.44 2.47e-31 Intelligence (multi-trait analysis); BRCA cis rs12467847 1.000 rs12467847 chr2:113691404 A/G cg12858261 chr2:113808755 IL1F8 0.36 7.88 0.3 1.45e-14 Response to amphetamines; BRCA cis rs9311474 0.629 rs7639267 chr3:52568805 G/T cg11041457 chr3:52719354 GNL3;PBRM1 0.26 8.35 0.31 4.37e-16 Electroencephalogram traits; BRCA cis rs701145 0.537 rs446144 chr3:153922154 T/C cg17054900 chr3:154042577 DHX36 0.51 8.9 0.33 5.93e-18 Coronary artery disease; BRCA cis rs35110281 0.667 rs2838354 chr21:45119857 T/C cg21573476 chr21:45109991 RRP1B -0.49 -12.43 -0.44 6.48e-32 Mean corpuscular volume; BRCA cis rs881375 0.967 rs10739579 chr9:123694788 C/A cg09586646 chr9:123605570 PSMD5;LOC253039 0.42 8.76 0.33 1.79e-17 Rheumatoid arthritis; BRCA cis rs6842047 1.000 rs1877320 chr4:187131279 G/A cg02012338 chr4:187126139 CYP4V2 0.88 10.12 0.37 2.01e-22 Blood protein levels; BRCA cis rs7615952 0.576 rs2276727 chr3:125826243 C/T cg06494592 chr3:125709126 NA -0.54 -8.4 -0.32 2.85e-16 Blood pressure (smoking interaction); BRCA cis rs798554 1.000 rs798554 chr7:2759795 C/T cg19346786 chr7:2764209 NA -0.37 -11.15 -0.4 1.67e-26 Height; BRCA cis rs4665809 0.590 rs2303892 chr2:26461733 C/G cg08067268 chr2:26466485 HADHB;HADHA 0.58 9.93 0.37 1.03e-21 Gut microbiome composition (summer); BRCA cis rs7772486 0.754 rs702304 chr6:145990797 A/G cg13319975 chr6:146136371 FBXO30 0.41 9.5 0.35 3.98e-20 Lobe attachment (rater-scored or self-reported); BRCA cis rs10479542 0.630 rs6879664 chr5:178974576 T/G cg26516362 chr5:178986906 RUFY1 0.33 7.92 0.3 1.05e-14 Lung cancer; BRCA cis rs1975991 0.521 rs1383059 chr3:187964407 T/C cg15417654 chr3:187959138 LPP 0.36 9.22 0.34 4.1e-19 White matter integrity (bipolar disorder risk interaction); BRCA cis rs35110281 0.591 rs162369 chr21:44931965 G/A cg01579765 chr21:45077557 HSF2BP -0.38 -9.93 -0.37 1.09e-21 Mean corpuscular volume; BRCA cis rs769267 0.930 rs1063966 chr19:19616742 G/A cg02546618 chr19:19431379 KIAA0892;SF4 0.38 9.21 0.34 4.71e-19 Tonsillectomy; BRCA cis rs67460515 0.596 rs35127376 chr3:160927289 T/C cg03342759 chr3:160939853 NMD3 -0.73 -15.04 -0.51 5.48e-44 Parkinson's disease; BRCA cis rs11098499 0.657 rs7664458 chr4:120371967 A/G cg09307838 chr4:120376055 NA 0.74 16.17 0.54 1.53e-49 Corneal astigmatism; BRCA cis rs4478858 0.735 rs1566961 chr1:31772450 G/A cg00250761 chr1:31883323 NA -0.32 -8.25 -0.31 9.14e-16 Alcohol dependence; BRCA cis rs897984 0.542 rs750952 chr16:31093954 C/T cg02466173 chr16:30829666 NA -0.45 -10.19 -0.37 1.07e-22 Dementia with Lewy bodies; BRCA cis rs867371 1.000 rs7166570 chr15:82466221 C/T cg00614314 chr15:82944287 LOC80154 0.42 8.86 0.33 7.7e-18 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs10504229 0.728 rs1495867 chr8:58155500 G/T cg21724239 chr8:58056113 NA 0.58 9.49 0.35 4.59e-20 Developmental language disorder (linguistic errors); BRCA cis rs1801251 0.963 rs35395584 chr2:233573698 G/C cg25237894 chr2:233734115 C2orf82 0.39 11.3 0.41 4.07e-27 Coronary artery disease; BRCA cis rs72781680 0.948 rs72796385 chr2:24170360 T/A cg20701182 chr2:24300061 SF3B14 0.6 9.39 0.35 1.02e-19 Lymphocyte counts; BRCA cis rs939658 1.000 rs17175798 chr15:79463960 A/G cg17916960 chr15:79447300 NA 0.44 11.02 0.4 5.8e-26 Refractive error; BRCA cis rs6088813 1.000 rs62211529 chr20:33959315 T/C cg14752227 chr20:34000481 UQCC -0.43 -9.15 -0.34 7.71e-19 Height; BRCA cis rs10256972 0.616 rs4998392 chr7:1113344 A/C cg09177884 chr7:1199841 ZFAND2A -0.44 -9.8 -0.36 3.24e-21 Longevity;Endometriosis; BRCA cis rs736408 0.609 rs2230534 chr3:52802402 A/C cg11041457 chr3:52719354 GNL3;PBRM1 0.33 10.36 0.38 2.27e-23 Bipolar disorder; BRCA cis rs698813 0.604 rs7565928 chr2:44489956 T/C cg18685995 chr2:44588913 PREPL;C2orf34 0.48 8.52 0.32 1.11e-16 Adverse response to chemotherapy in breast cancer (alopecia) (paclitaxel); BRCA cis rs9527 0.590 rs7089680 chr10:104802071 C/T cg04362960 chr10:104952993 NT5C2 -0.43 -9.8 -0.36 3.09e-21 Arsenic metabolism; BRCA cis rs10504229 1.000 rs74546828 chr8:58171678 A/G cg14926445 chr8:58193284 C8orf71 -0.45 -8.62 -0.32 5.3e-17 Developmental language disorder (linguistic errors); BRCA trans rs12517041 0.935 rs4701359 chr5:23284257 T/C ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.91 -0.3 1.12e-14 Calcium levels; BRCA cis rs11098499 0.863 rs3775841 chr4:120425777 A/C cg09307838 chr4:120376055 NA 0.69 14.0 0.48 4.65e-39 Corneal astigmatism; BRCA cis rs10751667 0.666 rs6597962 chr11:976351 C/T ch.11.42038R chr11:967971 AP2A2 0.5 15.66 0.53 4.83e-47 Alzheimer's disease (late onset); BRCA cis rs66573146 0.572 rs66819208 chr4:6946128 A/G cg26116260 chr4:7069785 GRPEL1 -0.59 -8.93 -0.33 4.43e-18 Granulocyte percentage of myeloid white cells; BRCA cis rs10782582 0.593 rs11589276 chr1:76105545 G/A cg10523679 chr1:76189770 ACADM -0.47 -9.04 -0.34 1.91e-18 Daytime sleep phenotypes; BRCA cis rs6912958 1.000 rs9294380 chr6:88152667 G/A cg12350822 chr6:88032061 C6orf162;GJB7 -0.31 -8.8 -0.33 1.31e-17 Monocyte percentage of white cells; BRCA cis rs12586317 0.620 rs12437439 chr14:35585669 C/A cg05294307 chr14:35346193 BAZ1A -0.61 -10.56 -0.39 3.85e-24 Psoriasis; BRCA cis rs1994135 0.715 rs10506110 chr12:33708552 A/C cg06521331 chr12:34319734 NA -0.46 -8.15 -0.31 1.89e-15 Resting heart rate; BRCA cis rs4665809 0.567 rs6711402 chr2:26430983 A/G cg22920501 chr2:26401640 FAM59B -0.87 -15.03 -0.51 6.18e-44 Gut microbiome composition (summer); BRCA cis rs8114671 0.562 rs2378292 chr20:33485178 T/C cg07148914 chr20:33460835 GGT7 0.47 10.0 0.37 5.78e-22 Height; BRCA cis rs2180341 0.920 rs9401951 chr6:127671632 A/C cg27446573 chr6:127587934 RNF146 0.88 20.18 0.62 1.94e-70 Breast cancer; BRCA cis rs4302748 0.774 rs58840739 chr7:36181940 C/T cg24442661 chr7:36192818 EEPD1 0.46 8.74 0.33 2.11e-17 Platelet count; BRCA cis rs1843834 0.838 rs6436506 chr2:225558242 T/C cg22455342 chr2:225449267 CUL3 0.33 8.02 0.3 5.09e-15 IgE levels in asthmatics (D.p. specific); BRCA cis rs9325144 0.555 rs7968322 chr12:38792348 T/C cg26384229 chr12:38710491 ALG10B -0.51 -12.15 -0.43 1.08e-30 Morning vs. evening chronotype; BRCA cis rs1881797 1.000 rs7527856 chr1:247688139 C/T cg21399703 chr1:247681439 NA 0.43 9.45 0.35 6.56e-20 Acute lymphoblastic leukemia (childhood); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg03923535 chr7:1197113 ZFAND2A 0.49 9.74 0.36 5.5e-21 Longevity;Endometriosis; BRCA cis rs7903847 0.596 rs9787426 chr10:99155327 A/G cg08345082 chr10:99160200 RRP12 -0.3 -8.72 -0.33 2.41e-17 Granulocyte percentage of myeloid white cells; BRCA cis rs9341808 0.667 rs806783 chr6:80942943 A/C cg08355045 chr6:80787529 NA -0.33 -7.94 -0.3 8.92e-15 Sitting height ratio; BRCA cis rs2153535 0.541 rs5026687 chr6:8473957 A/T cg23788917 chr6:8435910 SLC35B3 0.48 10.46 0.38 9.59e-24 Motion sickness; BRCA cis rs780096 0.546 rs715325 chr2:27725572 C/A cg22903471 chr2:27725779 GCKR -0.4 -9.76 -0.36 4.52e-21 Total body bone mineral density; BRCA cis rs7089973 0.584 rs7908665 chr10:116611337 G/A cg23260525 chr10:116636907 FAM160B1 0.32 8.47 0.32 1.67e-16 Bipolar disorder or attention deficit hyperactivity disorder; BRCA cis rs1506636 1.000 rs615410 chr7:123437765 T/C cg03229431 chr7:123269106 ASB15 0.56 12.39 0.44 9.78e-32 Plateletcrit;Platelet count; BRCA cis rs11123170 0.543 rs2863242 chr2:113989236 C/T cg21482265 chr2:113992762 PAX8;LOC440839;LOC654433 0.6 9.58 0.35 2.15e-20 Renal function-related traits (BUN); BRCA cis rs9811920 0.809 rs793464 chr3:99626028 G/A cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.55 13.52 0.47 8.15e-37 Axial length; BRCA cis rs911186 0.786 rs72842197 chr6:27067083 C/T cg18278486 chr6:26987575 LOC100270746;C6orf41 -0.32 -8.32 -0.31 5.43e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs17270561 0.609 rs12203927 chr6:25732690 A/G cg17691542 chr6:26056736 HIST1H1C 0.46 8.82 0.33 1.09e-17 Iron status biomarkers; BRCA trans rs641862 1 rs641862 chr13:110790232 C/T cg22783940 chr13:114251672 TFDP1 0.63 7.83 0.3 1.98e-14 Obesity-related traits; BRCA cis rs10504229 1.000 rs55787104 chr8:58178519 C/T cg22535103 chr8:58192502 C8orf71 -0.6 -13.01 -0.46 1.63e-34 Developmental language disorder (linguistic errors); BRCA cis rs2576037 0.583 rs9947131 chr18:44534769 G/T cg24750912 chr18:44543259 TCEB3CL;KATNAL2 0.33 8.18 0.31 1.51e-15 Personality dimensions; BRCA cis rs9473147 0.543 rs4711880 chr6:47480676 A/G cg12968598 chr6:47444699 CD2AP 0.46 9.86 0.36 1.85e-21 Platelet distribution width;Mean platelet volume; BRCA cis rs2108225 0.934 rs2190392 chr7:107452685 T/C cg18560240 chr7:107437656 SLC26A3 -0.51 -10.25 -0.38 6.52e-23 Ulcerative colitis; BRCA cis rs2635047 0.967 rs2571016 chr18:44639175 C/G cg19077165 chr18:44547161 KATNAL2 0.43 9.18 0.34 6.1e-19 Educational attainment; BRCA cis rs17854409 0.881 rs68091818 chr20:61479882 A/C cg07645718 chr20:61493192 TCFL5 0.65 8.48 0.32 1.52e-16 Obesity-related traits; BRCA cis rs769267 0.930 rs4808955 chr19:19552413 T/C cg11584989 chr19:19387371 SF4 0.3 7.9 0.3 1.24e-14 Tonsillectomy; BRCA cis rs3892630 0.588 rs8106748 chr19:33282797 G/A cg22980127 chr19:33182716 NUDT19 0.9 20.52 0.63 2.99e-72 Red blood cell traits; BRCA cis rs7666738 0.530 rs2865992 chr4:99067181 A/T cg05340658 chr4:99064831 C4orf37 0.5 11.59 0.42 2.56e-28 Colonoscopy-negative controls vs population controls; BRCA cis rs4819052 0.724 rs9753987 chr21:46661389 C/T cg19498844 chr21:46707878 POFUT2;LOC642852 0.65 14.02 0.48 4.03e-39 Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes; BRCA cis rs7647973 1.000 rs56127630 chr3:49438036 C/G cg07636037 chr3:49044803 WDR6 -0.73 -15.76 -0.53 1.62e-47 Menarche (age at onset); BRCA trans rs2736345 0.788 rs998683 chr8:11353000 A/G cg15556689 chr8:8085844 FLJ10661 -0.38 -8.55 -0.32 8.81e-17 Sjögren's syndrome;Systemic lupus erythematosus; BRCA trans rs2797160 1.000 rs1777183 chr6:126011995 A/C cg05039488 chr6:79577232 IRAK1BP1 0.36 7.99 0.3 6.53e-15 Endometrial cancer; BRCA cis rs651907 0.535 rs58658478 chr3:101511667 G/A cg11279151 chr3:101281821 RG9MTD1 -0.38 -8.48 -0.32 1.57e-16 Colorectal cancer; BRCA trans rs911555 0.755 rs975892 chr14:103883349 A/T cg17675199 chr6:35436792 RPL10A 0.3 8.07 0.3 3.49e-15 Intelligence (multi-trait analysis); BRCA trans rs3780486 1.000 rs10813957 chr9:33153527 G/T cg20290983 chr6:43655470 MRPS18A 0.97 22.15 0.66 4.37e-81 IgG glycosylation; BRCA cis rs4363385 0.655 rs11205163 chr1:152983677 C/T cg21543102 chr1:152974771 SPRR3 -0.29 -8.19 -0.31 1.41e-15 Inflammatory skin disease; BRCA cis rs40363 1.000 rs1635393 chr16:3520493 C/T cg00484396 chr16:3507460 NAT15 0.57 8.4 0.32 2.82e-16 Tuberculosis; BRCA cis rs10089 1.000 rs17164310 chr5:127493679 A/G cg25462716 chr5:127418816 SLC12A2;FLJ33630 0.63 14.09 0.49 1.82e-39 Ileal carcinoids; BRCA cis rs2180341 0.814 rs6919082 chr6:127737888 T/G cg27446573 chr6:127587934 RNF146 0.67 15.1 0.51 2.8e-44 Breast cancer; BRCA cis rs1552244 1.000 rs55822690 chr3:10128003 A/G cg00149659 chr3:10157352 C3orf10 0.76 13.06 0.46 9.78e-35 Alzheimer's disease; BRCA cis rs4363385 0.747 rs4240867 chr1:152954921 A/G cg25856811 chr1:152973957 SPRR3 0.32 8.95 0.33 3.82e-18 Inflammatory skin disease; BRCA trans rs7819412 0.811 rs2409691 chr8:10943276 C/T cg08975724 chr8:8085496 FLJ10661 -0.41 -8.53 -0.32 1.06e-16 Triglycerides; BRCA cis rs780096 0.565 rs10169261 chr2:27727314 C/T cg18428193 chr2:27665017 KRTCAP3;NRBP1 -0.3 -7.87 -0.3 1.58e-14 Total body bone mineral density; BRCA cis rs10751667 0.666 rs10902243 chr11:949900 T/C cg06064525 chr11:970664 AP2A2 -0.48 -16.15 -0.54 1.89e-49 Alzheimer's disease (late onset); BRCA cis rs709400 0.663 rs11623869 chr14:103883633 G/T cg26031613 chr14:104095156 KLC1 0.68 13.88 0.48 1.76e-38 Body mass index; BRCA cis rs3760982 0.546 rs73048681 chr19:44289945 T/C cg21496419 chr19:44306685 LYPD5 0.39 8.21 0.31 1.22e-15 Breast cancer (estrogen-receptor negative);Breast cancer; BRCA cis rs8072100 0.870 rs10432035 chr17:45624913 G/C cg25173405 chr17:45401733 C17orf57 0.48 9.84 0.36 2.24e-21 Very long-chain saturated fatty acid levels (fatty acid 20:0); BRCA cis rs1059312 0.771 rs7974764 chr12:129296588 G/C cg09035930 chr12:129282057 SLC15A4 0.49 13.79 0.48 4.53e-38 Systemic lupus erythematosus; BRCA trans rs7824557 0.815 rs2736372 chr8:11106041 T/C cg15556689 chr8:8085844 FLJ10661 -0.3 -8.19 -0.31 1.38e-15 Retinal vascular caliber; BRCA cis rs7246657 0.678 rs2972446 chr19:38129893 G/A cg23950597 chr19:37808831 NA 0.51 8.84 0.33 9.4e-18 Coronary artery calcification; BRCA cis rs7666738 0.830 rs28785514 chr4:98959135 G/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs2242116 0.796 rs4683296 chr3:46973820 G/C cg27129171 chr3:47204927 SETD2 -0.65 -14.4 -0.49 6.44e-41 Birth weight; BRCA cis rs12477438 0.501 rs6542868 chr2:99782848 A/C cg26064155 chr2:99771622 LIPT1;TSGA10 0.84 25.91 0.72 1.01e-101 Chronic sinus infection; BRCA trans rs11098499 0.754 rs10212775 chr4:120239244 G/C cg25214090 chr10:38739885 LOC399744 0.44 10.29 0.38 4.34e-23 Corneal astigmatism; BRCA cis rs17376456 0.825 rs10057130 chr5:93282557 C/T cg21475434 chr5:93447410 FAM172A 0.68 8.6 0.32 6.23e-17 Diabetic retinopathy; BRCA cis rs7772486 0.875 rs9403768 chr6:146406458 A/C cg13319975 chr6:146136371 FBXO30 -0.39 -8.8 -0.33 1.3e-17 Lobe attachment (rater-scored or self-reported); BRCA cis rs11098499 0.863 rs2170276 chr4:120485824 A/C cg09307838 chr4:120376055 NA 0.69 14.25 0.49 3.17e-40 Corneal astigmatism; BRCA cis rs7949030 0.626 rs7930896 chr11:62325272 A/G cg13298116 chr11:62369859 EML3;MTA2 0.55 13.23 0.46 1.73e-35 Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction);Waist-to-hip ratio adjusted for body mass index; BRCA cis rs7264396 0.790 rs6058297 chr20:34271861 G/C cg04508476 chr20:34239394 CPNE1;RBM12 -0.75 -15.96 -0.53 1.69e-48 Total cholesterol levels; BRCA trans rs12517041 0.935 rs10062553 chr5:23294800 G/A ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.94 -0.3 9.15e-15 Calcium levels; BRCA cis rs12477438 0.520 rs6542869 chr2:99783403 G/A cg14399236 chr2:99771627 LIPT1;TSGA10 0.82 22.89 0.67 3.9e-85 Chronic sinus infection; BRCA cis rs6901250 0.851 rs168128 chr6:117166865 A/G cg12892004 chr6:117198278 RFX6 -0.5 -11.5 -0.41 5.96e-28 C-reactive protein levels; BRCA cis rs1011018 0.590 rs74620925 chr7:139470733 C/T cg03224163 chr7:139420300 HIPK2 -0.59 -8.94 -0.33 4.16e-18 Systolic blood pressure; BRCA cis rs769267 0.930 rs7254927 chr19:19404786 C/G cg01262667 chr19:19385393 TM6SF2 0.41 10.57 0.39 3.41e-24 Tonsillectomy; BRCA cis rs701145 0.938 rs1086106 chr3:154084032 C/T cg17054900 chr3:154042577 DHX36 0.68 11.72 0.42 7.27e-29 Coronary artery disease; BRCA trans rs12310956 0.532 rs11052948 chr12:33981973 T/C cg13010199 chr12:38710504 ALG10B 0.49 9.41 0.35 9.16e-20 Morning vs. evening chronotype; BRCA cis rs6714710 0.603 rs35424768 chr2:98395653 A/C cg26665480 chr2:98280029 ACTR1B 0.58 13.59 0.47 4.06e-37 Posterior cortical atrophy and Alzheimer's disease; BRCA cis rs7408868 1.000 rs7249525 chr19:15277309 G/A cg14696996 chr19:15285081 NOTCH3 1.02 14.79 0.5 9.21e-43 Pulse pressure; BRCA cis rs3849570 0.643 rs11705789 chr3:81969196 G/T cg07356753 chr3:81810745 GBE1 -0.33 -7.89 -0.3 1.35e-14 Waist circumference;Body mass index; BRCA cis rs2832191 0.720 rs4643617 chr21:30485278 T/C cg08807101 chr21:30365312 RNF160 -0.61 -15.64 -0.53 6.71e-47 Dental caries; BRCA trans rs35847492 1.000 rs17730481 chr8:9276163 A/G cg15556689 chr8:8085844 FLJ10661 -0.36 -8.39 -0.32 3.08e-16 Neuroticism; BRCA cis rs2880765 0.835 rs7169632 chr15:86044667 T/G cg10818794 chr15:86012489 AKAP13 -0.3 -8.5 -0.32 1.34e-16 Coronary artery disease; BRCA cis rs1552244 1.000 rs2272123 chr3:10140115 G/A cg10729496 chr3:10149963 C3orf24 0.48 8.91 0.33 5.33e-18 Alzheimer's disease; BRCA cis rs6570726 0.935 rs419847 chr6:145827278 A/G cg23711669 chr6:146136114 FBXO30 0.64 14.77 0.5 1.09e-42 Lobe attachment (rater-scored or self-reported); BRCA cis rs727479 0.543 rs6493489 chr15:51514203 C/T cg19946085 chr15:51559439 CYP19A1 -0.29 -7.86 -0.3 1.6e-14 Estradiol levels; BRCA cis rs965469 0.724 rs6037527 chr20:3254412 T/G cg25506879 chr20:3388711 C20orf194 -0.45 -9.1 -0.34 1.12e-18 IFN-related cytopenia; BRCA cis rs7091068 0.522 rs11187621 chr10:95483074 T/C cg20715218 chr10:95462985 C10orf4 0.48 9.15 0.34 7.34e-19 Urinary tract infection frequency; BRCA cis rs7552404 1.000 rs11161515 chr1:76212559 C/T cg22875332 chr1:76189707 ACADM 0.69 14.48 0.5 2.59e-41 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs12477438 0.735 rs12474477 chr2:99690408 G/T cg08885076 chr2:99613938 TSGA10 -0.59 -13.21 -0.46 2.12e-35 Chronic sinus infection; BRCA cis rs6088580 0.634 rs6088512 chr20:33095891 G/A cg06115741 chr20:33292138 TP53INP2 0.35 7.89 0.3 1.29e-14 Glomerular filtration rate (creatinine); BRCA cis rs8114671 0.562 rs4911447 chr20:33479445 T/A cg07148914 chr20:33460835 GGT7 0.38 8.52 0.32 1.14e-16 Height; BRCA trans rs6479901 0.512 rs7100372 chr10:65064244 T/C cg14819942 chr15:35414228 NA -0.35 -8.56 -0.32 8.37e-17 Intelligence (multi-trait analysis); BRCA trans rs877282 0.891 rs34383514 chr10:800181 T/C cg22713356 chr15:30763199 NA 1.4 28.4 0.75 2.36e-115 Uric acid levels; BRCA cis rs7811142 1.000 rs11761725 chr7:100039815 C/T cg21679810 chr7:100027352 MEPCE;ZCWPW1 1.06 17.08 0.56 3.51e-54 Platelet count; BRCA cis rs9814567 1.000 rs1880376 chr3:134270347 A/G cg06541857 chr3:134203789 ANAPC13;CEP63 0.37 8.33 0.31 4.94e-16 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA cis rs769267 0.931 rs2965197 chr19:19470910 C/T cg03709012 chr19:19516395 GATAD2A -0.75 -16.65 -0.55 5.94e-52 Tonsillectomy; BRCA cis rs9487051 0.803 rs11153161 chr6:109541774 A/G cg01475377 chr6:109611718 NA -0.42 -9.79 -0.36 3.55e-21 Reticulocyte fraction of red cells; BRCA trans rs7395662 0.853 rs35255233 chr11:48442870 T/A cg00717180 chr2:96193071 NA -0.28 -7.83 -0.3 2.05e-14 HDL cholesterol; BRCA cis rs1355223 0.583 rs2941043 chr11:34870994 A/G cg24088639 chr11:34937564 PDHX;APIP 0.41 9.21 0.34 4.66e-19 Systemic lupus erythematosus and Systemic sclerosis; BRCA cis rs2549003 1.000 rs9282763 chr5:131822133 T/C cg02551604 chr5:131831745 NA -0.4 -14.95 -0.51 1.56e-43 Asthma (sex interaction); BRCA cis rs6952808 0.582 rs11763870 chr7:2027448 T/C cg03354898 chr7:1950403 MAD1L1 0.38 8.57 0.32 7.99e-17 Bipolar disorder and schizophrenia; BRCA cis rs8077889 0.645 rs1230393 chr17:41842592 A/G cg26893861 chr17:41843967 DUSP3 -1.06 -29.73 -0.76 1.27e-122 Triglycerides; BRCA cis rs4891159 0.790 rs7241485 chr18:74122325 C/T cg24786174 chr18:74118243 ZNF516 -0.78 -18.83 -0.6 2.97e-63 Longevity; BRCA cis rs698833 0.537 rs698826 chr2:44728418 C/T cg18685995 chr2:44588913 PREPL;C2orf34 0.46 8.76 0.33 1.81e-17 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs2576037 0.796 rs2576034 chr18:44588548 G/A cg24750912 chr18:44543259 TCEB3CL;KATNAL2 -0.32 -8.18 -0.31 1.49e-15 Personality dimensions; BRCA cis rs1008375 1.000 rs4698649 chr4:17692782 A/G cg02297831 chr4:17616191 MED28 0.36 8.42 0.32 2.43e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs10751667 0.643 rs6597969 chr11:928843 C/T cg06064525 chr11:970664 AP2A2 -0.48 -16.03 -0.54 7.33e-49 Alzheimer's disease (late onset); BRCA cis rs11051970 0.879 rs2088806 chr12:32592125 C/T cg24626660 chr12:32551988 NA 0.29 8.3 0.31 6.16e-16 Response to tocilizumab in rheumatoid arthritis; BRCA trans rs931812 0.757 rs4734014 chr8:101908844 A/G cg20993868 chr7:22813445 NA 0.44 13.33 0.47 5.96e-36 Attention deficit hyperactivity disorder and conduct disorder; BRCA cis rs9649213 0.555 rs67132564 chr7:98014900 T/A cg01877450 chr7:97915802 BRI3 -0.38 -8.63 -0.32 4.87e-17 Prostate cancer (SNP x SNP interaction); BRCA trans rs2204008 0.744 rs11181337 chr12:38322083 C/A cg06521331 chr12:34319734 NA -0.46 -9.05 -0.34 1.75e-18 Bladder cancer; BRCA cis rs2836974 0.931 rs7283569 chr21:40644062 T/G cg11644478 chr21:40555479 PSMG1 0.84 19.08 0.6 1.5e-64 Cognitive function; BRCA cis rs2011503 0.941 rs56135441 chr19:19371370 A/T cg15839431 chr19:19639596 YJEFN3 -0.36 -8.08 -0.3 3.2e-15 Bipolar disorder; BRCA cis rs9435341 0.965 rs2335077 chr1:107573565 A/G cg09367891 chr1:107599246 PRMT6 0.42 8.22 0.31 1.11e-15 Facial morphology (factor 21, depth of nasal alae); BRCA cis rs6952808 1.000 rs4449693 chr7:1884630 G/C cg14004847 chr7:1930337 MAD1L1 -0.45 -8.59 -0.32 6.73e-17 Bipolar disorder and schizophrenia; BRCA cis rs60871478 1.000 rs34761279 chr7:794471 A/G cg05535760 chr7:792225 HEATR2 0.83 14.42 0.5 4.97e-41 Cerebrospinal P-tau181p levels; BRCA cis rs7824557 0.591 rs2736283 chr8:11225910 A/G cg21775007 chr8:11205619 TDH -0.62 -13.41 -0.47 2.64e-36 Retinal vascular caliber; BRCA cis rs208520 0.690 rs12208977 chr6:66725257 G/A cg07460842 chr6:66804631 NA 0.98 19.59 0.61 2.75e-67 Exhaled nitric oxide output; BRCA cis rs35146811 0.771 rs1060544 chr7:99613476 C/T cg03265037 chr7:99691720 MIR25;MCM7;MIR106B;MIR93 0.35 7.85 0.3 1.71e-14 Coronary artery disease; BRCA cis rs1707322 0.721 rs61784796 chr1:46163256 A/G cg03146154 chr1:46216737 IPP 0.53 11.89 0.43 1.37e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs11105298 0.891 rs10858864 chr12:89846230 C/T cg00757033 chr12:89920650 WDR51B 0.53 10.74 0.39 7.86e-25 B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio; BRCA cis rs7646881 0.812 rs7636023 chr3:158460059 T/C cg19483011 chr3:158453295 NA -0.46 -8.05 -0.3 4.08e-15 Tetralogy of Fallot; BRCA cis rs6121246 0.954 rs6058470 chr20:30416827 A/T cg13852791 chr20:30311386 BCL2L1 0.82 15.98 0.53 1.31e-48 Mean corpuscular hemoglobin; BRCA cis rs35306767 0.715 rs1871622 chr10:1049309 T/G cg20503657 chr10:835505 NA 0.95 14.77 0.5 1.14e-42 Eosinophil percentage of granulocytes; BRCA cis rs10464366 0.560 rs12672089 chr7:39132816 G/A cg18850127 chr7:39170497 POU6F2 0.48 10.13 0.37 1.81e-22 IgG glycosylation; BRCA cis rs798554 0.757 rs1182185 chr7:2872233 A/G cg13628971 chr7:2884303 GNA12 0.47 9.97 0.37 7.71e-22 Height; BRCA cis rs593982 1.000 rs470360 chr11:65500530 T/C cg08755490 chr11:65554678 OVOL1 1.27 29.33 0.76 1.95e-120 Atopic dermatitis; BRCA cis rs4243830 0.850 rs10864612 chr1:6593830 C/G cg22792644 chr1:6614718 TAS1R1;NOL9 -0.87 -17.41 -0.57 7.87e-56 Body mass index; BRCA cis rs6964587 1.000 rs10228800 chr7:91610111 T/G cg01689657 chr7:91764605 CYP51A1 0.22 7.92 0.3 1.09e-14 Breast cancer; BRCA cis rs3008870 0.755 rs2755271 chr1:67474977 C/T cg08660285 chr1:67390436 MIER1;WDR78 0.64 14.05 0.49 2.94e-39 Lymphocyte percentage of white cells; BRCA cis rs11098499 0.604 rs10022185 chr4:120571765 C/G cg09307838 chr4:120376055 NA 0.58 10.81 0.39 3.98e-25 Corneal astigmatism; BRCA cis rs6964587 0.621 rs39744 chr7:92043016 A/G cg17063962 chr7:91808500 NA 0.48 10.93 0.4 1.25e-25 Breast cancer; BRCA cis rs35110281 0.805 rs162402 chr21:44963418 G/C cg04455712 chr21:45112962 RRP1B 0.4 10.4 0.38 1.58e-23 Mean corpuscular volume; BRCA cis rs10751667 1.000 rs10751667 chr11:941941 A/T cg06064525 chr11:970664 AP2A2 -0.33 -9.52 -0.35 3.48e-20 Alzheimer's disease (late onset); BRCA cis rs2243480 0.901 rs1701759 chr7:65470932 G/T cg18252515 chr7:66147081 NA -0.86 -12.38 -0.44 1.04e-31 Diabetic kidney disease; BRCA cis rs10256972 0.721 rs2030959 chr7:1075906 T/C cg16145915 chr7:1198662 ZFAND2A -0.49 -11.16 -0.4 1.46e-26 Longevity;Endometriosis; BRCA cis rs10479542 0.766 rs7733389 chr5:178974997 C/T cg14820908 chr5:178986412 RUFY1 0.37 9.24 0.34 3.7e-19 Lung cancer; BRCA cis rs10851411 0.697 rs113979838 chr15:42792353 T/C cg21293051 chr15:42870591 STARD9 0.51 8.37 0.31 3.54e-16 Glucose homeostasis traits; BRCA cis rs765787 0.530 rs4775822 chr15:45527127 A/G cg15395560 chr15:45543142 SLC28A2 0.29 8.25 0.31 9.02e-16 Uric acid levels; BRCA cis rs9291683 0.507 rs6849273 chr4:10021595 C/T cg00071950 chr4:10020882 SLC2A9 0.56 13.89 0.48 1.6e-38 Bone mineral density; BRCA cis rs1552244 0.572 rs68121641 chr3:10165845 T/A cg16606324 chr3:10149918 C3orf24 0.57 10.04 0.37 3.9e-22 Alzheimer's disease; BRCA cis rs4665809 0.590 rs13006973 chr2:26454707 C/T cg08067268 chr2:26466485 HADHB;HADHA 0.58 10.28 0.38 4.65e-23 Gut microbiome composition (summer); BRCA cis rs7264396 0.570 rs6060717 chr20:34544647 T/C cg23207816 chr20:34252616 CPNE1;RBM12 0.39 8.29 0.31 6.64e-16 Total cholesterol levels; BRCA cis rs2739330 0.587 rs4820571 chr22:24242973 A/G cg09033563 chr22:24373618 LOC391322 -0.39 -8.08 -0.3 3.13e-15 Liver enzyme levels (gamma-glutamyl transferase); BRCA trans rs7819412 0.668 rs920047 chr8:11087475 C/T cg06636001 chr8:8085503 FLJ10661 -0.44 -9.28 -0.34 2.51e-19 Triglycerides; BRCA cis rs10256972 0.758 rs4723649 chr7:1071905 T/C cg15112475 chr7:1198522 ZFAND2A -0.39 -8.33 -0.31 4.81e-16 Longevity;Endometriosis; BRCA cis rs7552404 0.731 rs2029683 chr1:76341643 T/G cg03433033 chr1:76189801 ACADM -0.6 -11.81 -0.42 3.05e-29 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs6121246 0.559 rs6121243 chr20:30415094 C/G cg21427119 chr20:30132790 HM13 -0.35 -7.95 -0.3 8.73e-15 Mean corpuscular hemoglobin; BRCA cis rs6461049 0.800 rs2398706 chr7:2156338 A/T cg14004847 chr7:1930337 MAD1L1 -0.43 -8.44 -0.32 2.15e-16 Schizophrenia; BRCA cis rs910316 0.737 rs175055 chr14:75488946 T/G cg08847533 chr14:75593920 NEK9 -0.83 -20.65 -0.63 5.59e-73 Height; BRCA cis rs12618769 0.597 rs55934321 chr2:99099417 G/A cg10123293 chr2:99228465 UNC50 0.42 8.18 0.31 1.53e-15 Bipolar disorder; BRCA cis rs4722166 0.695 rs35779989 chr7:22800314 A/C cg26061582 chr7:22766209 IL6 0.35 8.06 0.3 3.7e-15 Lung cancer; BRCA cis rs7552404 1.000 rs441109 chr1:76120430 T/G cg10523679 chr1:76189770 ACADM -0.76 -15.83 -0.53 7.67e-48 Blood metabolite levels;Acylcarnitine levels; BRCA cis rs867371 1.000 rs7180584 chr15:82455834 A/G cg00614314 chr15:82944287 LOC80154 0.44 9.12 0.34 9.52e-19 Cognitive ability;Cognitive ability (multi-trait analysis); BRCA cis rs666930 0.519 rs483180 chr1:120267505 C/G cg19096424 chr1:120255104 PHGDH -0.62 -13.44 -0.47 2e-36 Breast cancer; BRCA cis rs1707322 0.721 rs6429574 chr1:46134054 A/G cg24296786 chr1:45957014 TESK2 -0.39 -8.06 -0.3 3.84e-15 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs10504229 0.728 rs56180705 chr8:58149734 T/C cg21724239 chr8:58056113 NA 0.6 9.63 0.36 1.35e-20 Developmental language disorder (linguistic errors); BRCA cis rs10504229 0.683 rs6999131 chr8:58127052 C/A cg11062466 chr8:58055876 NA 0.5 8.77 0.33 1.63e-17 Developmental language disorder (linguistic errors); BRCA cis rs7811142 1.000 rs66632384 chr7:100018904 G/A cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.09 22.2 0.66 2.32e-81 Platelet count; BRCA cis rs7249921 0.833 rs6510469 chr19:35672008 G/T cg15419183 chr19:35660584 FXYD5 0.46 10.34 0.38 2.72e-23 Platelet count; BRCA cis rs9790314 0.730 rs4856705 chr3:161100219 T/G cg03342759 chr3:160939853 NMD3 -0.55 -11.98 -0.43 5.68e-30 Morning vs. evening chronotype; BRCA cis rs3849570 0.695 rs6792696 chr3:81874009 G/A cg07356753 chr3:81810745 GBE1 -0.4 -9.56 -0.35 2.6e-20 Waist circumference;Body mass index; BRCA cis rs7582180 0.629 rs13004216 chr2:100945402 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.82 0.42 2.63e-29 Intelligence (multi-trait analysis); BRCA trans rs9951602 0.512 rs4799247 chr18:76653449 G/A cg02800362 chr5:177631904 HNRNPAB 0.77 18.23 0.58 4.25e-60 Obesity-related traits; BRCA cis rs62034325 0.697 rs710410 chr16:28603342 A/G cg16576597 chr16:28551801 NUPR1 0.34 8.58 0.32 6.98e-17 Body mass index; BRCA cis rs2839186 0.721 rs3788252 chr21:47661235 C/T cg13732083 chr21:47605072 C21orf56 0.37 7.86 0.3 1.61e-14 Testicular germ cell tumor; BRCA cis rs17601876 0.843 rs28490942 chr15:51559845 G/C cg19946085 chr15:51559439 CYP19A1 -0.38 -11.58 -0.42 2.72e-28 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs908922 0.651 rs1572534 chr1:152509689 G/A cg20991723 chr1:152506922 NA 0.39 8.95 0.33 3.69e-18 Hair morphology; BRCA trans rs12517041 1.000 rs1593967 chr5:23313900 C/T ch.8.1293020R chr8:59333349 UBXN2B -0.46 -7.84 -0.3 1.84e-14 Calcium levels; BRCA cis rs812925 0.512 rs7558954 chr2:61384906 T/C cg15711740 chr2:61764176 XPO1 -0.32 -8.0 -0.3 5.8e-15 Immature fraction of reticulocytes; BRCA cis rs7666738 0.830 rs13101766 chr4:98957696 C/A cg05340658 chr4:99064831 C4orf37 0.68 16.94 0.56 1.9e-53 Colonoscopy-negative controls vs population controls; BRCA cis rs6952808 0.624 rs60137119 chr7:2083664 A/G cg04267008 chr7:1944627 MAD1L1 -0.64 -13.95 -0.48 8.14e-39 Bipolar disorder and schizophrenia; BRCA cis rs9807989 0.524 rs6543126 chr2:103027104 G/A cg03938978 chr2:103052716 IL18RAP 0.29 8.21 0.31 1.2e-15 Asthma; BRCA cis rs7618915 0.547 rs8906 chr3:52739520 T/C cg11041457 chr3:52719354 GNL3;PBRM1 0.34 10.71 0.39 1.01e-24 Bipolar disorder; BRCA cis rs1008375 1.000 rs4698648 chr4:17692715 C/G cg02297831 chr4:17616191 MED28 0.36 8.42 0.32 2.43e-16 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs4481887 0.790 rs10888364 chr1:248488387 T/G cg13385794 chr1:248469461 NA 0.27 7.89 0.3 1.32e-14 Common traits (Other); BRCA cis rs35110281 0.712 rs167930 chr21:44946625 G/A cg21573476 chr21:45109991 RRP1B -0.36 -9.55 -0.35 2.67e-20 Mean corpuscular volume; BRCA cis rs1865760 0.964 rs3799373 chr6:25929173 A/C cg17691542 chr6:26056736 HIST1H1C 0.52 10.45 0.38 1.08e-23 Height; BRCA trans rs7618501 0.722 rs9853458 chr3:49783211 A/C cg21659725 chr3:3221576 CRBN -0.71 -21.71 -0.65 1.04e-78 Intelligence (multi-trait analysis); BRCA cis rs769267 0.930 rs3794990 chr19:19610030 A/G cg26732615 chr19:19648335 CILP2;YJEFN3 0.37 8.09 0.3 2.91e-15 Tonsillectomy; BRCA cis rs11690935 0.959 rs3770452 chr2:172668682 A/G cg13550731 chr2:172543902 DYNC1I2 -0.92 -30.51 -0.77 8.1e-127 Schizophrenia; BRCA cis rs136211 0.619 rs9607337 chr22:36758849 A/T cg21778268 chr22:36877729 TXN2 -0.36 -8.26 -0.31 8.2e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs12579753 0.956 rs34747993 chr12:82217777 C/T cg07988820 chr12:82153109 PPFIA2 -0.6 -9.7 -0.36 7.72e-21 Resting heart rate; BRCA cis rs67478160 0.608 rs11160760 chr14:104248938 G/T cg26031613 chr14:104095156 KLC1 -0.42 -8.49 -0.32 1.5e-16 Schizophrenia; BRCA cis rs3931020 0.508 rs11485298 chr1:75217752 C/T cg00121533 chr1:75199117 CRYZ;TYW3 0.43 8.26 0.31 8.1e-16 Resistin levels; BRCA cis rs7647973 0.506 rs11920251 chr3:49356671 C/T cg06212747 chr3:49208901 KLHDC8B 0.44 9.29 0.35 2.32e-19 Menarche (age at onset); BRCA cis rs6840360 0.593 rs10033405 chr4:152474489 A/G cg22705602 chr4:152727874 NA -0.32 -8.24 -0.31 9.68e-16 Intelligence (multi-trait analysis); BRCA cis rs35110281 0.748 rs1584918 chr21:45042419 C/T cg21573476 chr21:45109991 RRP1B -0.37 -9.64 -0.36 1.32e-20 Mean corpuscular volume; BRCA cis rs35110281 0.591 rs230642 chr21:44915533 A/C cg01579765 chr21:45077557 HSF2BP 0.37 9.89 0.36 1.51e-21 Mean corpuscular volume; BRCA cis rs13191362 0.507 rs2023037 chr6:163120385 C/T cg21926612 chr6:163149169 PACRG;PARK2 0.53 10.29 0.38 4.45e-23 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA cis rs9900497 0.536 rs4646785 chr17:19651902 A/G cg22552966 chr17:19620595 SLC47A2 -0.32 -8.06 -0.3 3.63e-15 Response to paliperidone in schizophrenia (CGI-S score); BRCA cis rs911555 0.576 rs8015723 chr14:103895909 A/G cg12935359 chr14:103987150 CKB 0.53 11.66 0.42 1.26e-28 Intelligence (multi-trait analysis); BRCA cis rs3892630 0.817 rs12609866 chr19:33184412 C/T cg22980127 chr19:33182716 NUDT19 0.89 17.96 0.58 1.09e-58 Red blood cell traits; BRCA cis rs9393777 0.623 rs9358945 chr6:26472114 C/T cg12826209 chr6:26865740 GUSBL1 -0.54 -9.11 -0.34 1.01e-18 Intelligence (multi-trait analysis); BRCA cis rs597539 0.652 rs546382 chr11:68704264 C/T cg11716795 chr11:68671300 MRPL21;IGHMBP2 0.78 18.33 0.59 1.25e-60 Coronary artery calcified atherosclerotic plaque score in type 2 diabetes; BRCA cis rs7582180 0.663 rs10199518 chr2:100946041 G/A cg14675211 chr2:100938903 LONRF2 0.43 9.53 0.35 3.14e-20 Intelligence (multi-trait analysis); BRCA cis rs17401966 0.894 rs12141201 chr1:10454714 G/A cg19773385 chr1:10388646 KIF1B -0.38 -8.14 -0.31 2.12e-15 Hepatocellular carcinoma; BRCA cis rs3733585 0.699 rs6449202 chr4:9974043 T/C cg11266682 chr4:10021025 SLC2A9 -0.39 -10.4 -0.38 1.67e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs514406 0.621 rs928452 chr1:53195926 G/C cg08859206 chr1:53392774 SCP2 0.42 8.31 0.31 5.65e-16 Monocyte count; BRCA cis rs12477438 0.798 rs6761570 chr2:99577276 T/G cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.68 -0.5 3.02e-42 Chronic sinus infection; BRCA cis rs270601 0.913 rs273916 chr5:131659830 C/A cg24060327 chr5:131705240 SLC22A5 -0.63 -12.26 -0.44 3.58e-31 Acylcarnitine levels; BRCA cis rs6484504 0.576 rs158136 chr11:31220712 C/T cg14844989 chr11:31128820 NA -0.45 -9.62 -0.36 1.51e-20 Red blood cell count; BRCA cis rs6912958 0.712 rs6908386 chr6:88354746 T/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.41 -8.3 -0.31 6.07e-16 Monocyte percentage of white cells; BRCA cis rs2019137 0.936 rs3828188 chr2:113954247 G/A cg07772999 chr2:113993052 PAX8;LOC440839;LOC654433 -0.53 -10.6 -0.39 2.68e-24 Lymphocyte counts; BRCA trans rs7980799 0.649 rs2220059 chr12:33648630 C/T cg26384229 chr12:38710491 ALG10B -0.45 -9.67 -0.36 9.67e-21 Heart rate;Heart rate variability traits (RMSSD); BRCA cis rs2019137 0.936 rs12612729 chr2:113957048 G/A cg19083407 chr2:113993142 PAX8;LOC440839;LOC654433 -0.56 -11.56 -0.42 3.28e-28 Lymphocyte counts; BRCA trans rs3780486 0.846 rs73484568 chr9:33132492 G/A cg04842962 chr6:43655489 MRPS18A 1.11 38.55 0.84 7e-169 IgG glycosylation; BRCA cis rs6952808 0.689 rs4719391 chr7:2048136 T/C cg18279126 chr7:2041391 MAD1L1 0.39 8.98 0.33 3.1e-18 Bipolar disorder and schizophrenia; BRCA cis rs11249608 0.548 rs62393074 chr5:178450476 G/C cg21905437 chr5:178450457 ZNF879 0.53 11.1 0.4 2.76e-26 Pubertal anthropometrics; BRCA cis rs10751667 0.666 rs11246357 chr11:963980 A/C cg01483505 chr11:975446 AP2A2 0.33 8.95 0.33 3.8e-18 Alzheimer's disease (late onset); BRCA cis rs738322 0.555 rs5750547 chr22:38546700 A/G cg25457927 chr22:38595422 NA 0.35 12.89 0.45 5.72e-34 Cutaneous nevi; BRCA cis rs7267979 0.933 rs11699203 chr20:25435169 G/C cg24626310 chr20:25276739 ABHD12;PYGB 0.34 9.41 0.35 8.46e-20 Liver enzyme levels (alkaline phosphatase); BRCA cis rs2011503 1.000 rs8105642 chr19:19558468 G/A cg11584989 chr19:19387371 SF4 0.63 13.52 0.47 7.85e-37 Bipolar disorder; BRCA cis rs427394 0.659 rs187295 chr5:6734326 C/T cg10857441 chr5:6722123 POLS -0.3 -9.53 -0.35 3.34e-20 Menopause (age at onset); BRCA cis rs2180341 1.000 rs9321073 chr6:127609691 C/T cg27446573 chr6:127587934 RNF146 0.9 21.07 0.64 2.99e-75 Breast cancer; BRCA cis rs1008375 0.900 rs7658447 chr4:17579415 T/C cg27347728 chr4:17578864 LAP3 0.43 8.04 0.3 4.27e-15 Parasitemia in Tripanosoma cruzi seropositivity; BRCA cis rs12579753 0.879 rs12579544 chr12:82164043 A/C cg07988820 chr12:82153109 PPFIA2 -0.67 -11.92 -0.43 1.03e-29 Resting heart rate; BRCA cis rs6952808 0.630 rs1860832 chr7:2161849 G/A cg02951883 chr7:2050386 MAD1L1 -0.54 -12.27 -0.44 3.31e-31 Bipolar disorder and schizophrenia; BRCA cis rs2153535 0.580 rs2184584 chr6:8468407 T/C cg21535247 chr6:8435926 SLC35B3 0.39 8.88 0.33 6.9e-18 Motion sickness; BRCA cis rs6912958 0.781 rs9444512 chr6:88223397 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -8.6 -0.32 6.33e-17 Monocyte percentage of white cells; BRCA cis rs6912958 0.631 rs9450704 chr6:88182704 G/C cg08069147 chr6:88032118 GJB7;C6orf162 -0.43 -8.41 -0.32 2.77e-16 Monocyte percentage of white cells; BRCA cis rs10752881 1.000 rs8179262 chr1:182973186 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.83 0.55 7.34e-53 Colorectal cancer; BRCA trans rs7618501 1.000 rs4855867 chr3:49745822 C/T cg21582582 chr3:182698605 DCUN1D1 -0.4 -10.45 -0.38 1.08e-23 Intelligence (multi-trait analysis); BRCA cis rs9790314 0.560 rs4856701 chr3:161044106 G/T cg04691961 chr3:161091175 C3orf57 -0.4 -9.28 -0.34 2.7e-19 Morning vs. evening chronotype; BRCA cis rs12682352 0.579 rs7006589 chr8:8668486 A/G cg08975724 chr8:8085496 FLJ10661 0.38 7.84 0.3 1.84e-14 Neuroticism; BRCA cis rs4555082 0.874 rs2816626 chr14:105735425 G/A cg13114125 chr14:105738426 BRF1 -0.53 -11.06 -0.4 3.95e-26 Mean platelet volume;Platelet distribution width; BRCA cis rs6878727 0.665 rs161012 chr5:123674990 C/T cg01806427 chr5:123737813 NA -0.36 -8.15 -0.31 1.97e-15 Breast cancer; BRCA cis rs3733585 0.699 rs7663079 chr4:9966771 T/C cg00071950 chr4:10020882 SLC2A9 -0.44 -10.43 -0.38 1.23e-23 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs7666738 0.861 rs5010991 chr4:98972179 A/G cg17366294 chr4:99064904 C4orf37 0.44 10.46 0.38 9.87e-24 Colonoscopy-negative controls vs population controls; BRCA cis rs8177253 1.000 rs8177240 chr3:133477701 T/G cg11941060 chr3:133502564 NA -0.49 -11.68 -0.42 1.11e-28 Iron status biomarkers; BRCA cis rs8177253 0.965 rs3811658 chr3:133476852 C/T cg11941060 chr3:133502564 NA -0.5 -11.91 -0.43 1.16e-29 Iron status biomarkers; BRCA cis rs2204008 0.580 rs11520047 chr12:38051778 T/A cg13010199 chr12:38710504 ALG10B 0.51 10.07 0.37 2.99e-22 Bladder cancer; BRCA cis rs514406 0.760 rs475969 chr1:53292607 T/A cg16325326 chr1:53192061 ZYG11B 0.58 13.04 0.46 1.24e-34 Monocyte count; BRCA cis rs4665809 0.590 rs5001914 chr2:26415429 A/G cg08470875 chr2:26401718 FAM59B -0.78 -12.17 -0.43 8.7e-31 Gut microbiome composition (summer); BRCA cis rs7631605 0.905 rs6786906 chr3:37226016 T/C cg15934958 chr3:37212084 LRRFIP2 0.39 9.26 0.34 3.01e-19 Cerebrospinal P-tau181p levels; BRCA cis rs10927875 0.518 rs1763597 chr1:16343297 C/T cg06159980 chr1:16340746 HSPB7 -0.38 -8.83 -0.33 1.01e-17 Dilated cardiomyopathy; BRCA cis rs2153535 0.541 rs6923558 chr6:8461467 T/G cg23788917 chr6:8435910 SLC35B3 0.48 10.36 0.38 2.42e-23 Motion sickness; BRCA cis rs7903847 0.642 rs7903562 chr10:99154782 T/C cg20016023 chr10:99160130 RRP12 -0.25 -8.18 -0.31 1.56e-15 Granulocyte percentage of myeloid white cells; BRCA cis rs7267979 0.873 rs6115093 chr20:25210730 C/T cg08601574 chr20:25228251 PYGB 0.41 9.35 0.35 1.43e-19 Liver enzyme levels (alkaline phosphatase); BRCA cis rs7937890 0.904 rs11023169 chr11:14290985 C/A cg22961513 chr11:14280813 SPON1 0.32 8.07 0.3 3.44e-15 Mitochondrial DNA levels; BRCA cis rs6752107 0.935 rs1596017 chr2:234147930 C/T cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.48 10.45 0.38 1.09e-23 Crohn's disease;Inflammatory bowel disease; BRCA cis rs9527 0.569 rs10786730 chr10:104724200 G/A cg04362960 chr10:104952993 NT5C2 0.45 10.39 0.38 1.84e-23 Arsenic metabolism; BRCA trans rs11250097 0.549 rs11784897 chr8:11310442 G/A cg15556689 chr8:8085844 FLJ10661 -0.41 -10.46 -0.38 9.35e-24 Neuroticism; BRCA cis rs9733 0.650 rs2048558 chr1:150571730 A/G cg13175981 chr1:150552382 MCL1 0.54 11.86 0.42 1.83e-29 Tonsillectomy; BRCA cis rs13256369 0.851 rs11786125 chr8:8564570 T/G cg17143192 chr8:8559678 CLDN23 0.57 11.1 0.4 2.61e-26 Obesity-related traits; BRCA trans rs1005277 0.579 rs1740735 chr10:38497777 A/C cg17830980 chr10:43048298 ZNF37B -0.53 -12.79 -0.45 1.66e-33 Extrinsic epigenetic age acceleration; BRCA cis rs698833 0.852 rs2241869 chr2:44549229 A/G cg18685995 chr2:44588913 PREPL;C2orf34 -0.5 -9.93 -0.37 1.02e-21 antipsychotic drug dosage in schizophrenia or schizoaffective disorder; BRCA cis rs6842047 1.000 rs6842047 chr4:187133576 A/C cg23442198 chr4:187126114 CYP4V2 0.94 11.58 0.42 2.71e-28 Blood protein levels; BRCA cis rs796364 0.806 rs203767 chr2:200902411 G/A cg12253985 chr2:200820533 C2orf60;C2orf47 -0.66 -10.34 -0.38 2.72e-23 Schizophrenia; BRCA cis rs9790314 0.586 rs73021449 chr3:161128941 G/A cg04691961 chr3:161091175 C3orf57 -0.4 -9.23 -0.34 3.79e-19 Morning vs. evening chronotype; BRCA cis rs477895 0.653 rs11606544 chr11:63896901 C/T cg23719950 chr11:63933701 MACROD1 -0.54 -9.02 -0.34 2.09e-18 Mean platelet volume; BRCA cis rs6582630 0.555 rs34884627 chr12:38443831 C/T cg26384229 chr12:38710491 ALG10B -0.43 -10.07 -0.37 3.08e-22 Drug-induced liver injury (flucloxacillin); BRCA cis rs2836950 0.762 rs8134638 chr21:40644170 T/C cg11644478 chr21:40555479 PSMG1 -0.44 -8.62 -0.32 5.08e-17 Menarche (age at onset); BRCA cis rs10256972 0.706 rs12701969 chr7:1121849 A/G cg26608667 chr7:1196370 ZFAND2A 0.42 9.14 0.34 7.87e-19 Longevity;Endometriosis; BRCA cis rs7647973 0.626 rs11130217 chr3:49737323 A/G cg03060546 chr3:49711283 APEH 0.59 10.21 0.37 9.07e-23 Menarche (age at onset); BRCA cis rs1348850 0.914 rs10170667 chr2:178336878 A/G cg02961200 chr2:178257176 LOC100130691;AGPS 0.48 9.83 0.36 2.45e-21 Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL); BRCA cis rs1865760 0.533 rs1408270 chr6:25873184 A/G cg17691542 chr6:26056736 HIST1H1C 0.6 11.68 0.42 1.08e-28 Height; BRCA cis rs9381040 0.748 rs9357348 chr6:41154232 A/G cg09580153 chr6:41068724 NFYA;LOC221442 -0.4 -8.87 -0.33 7.35e-18 Alzheimer's disease (late onset); BRCA cis rs875971 0.642 rs35526611 chr7:66094008 C/T cg18876405 chr7:65276391 NA -0.64 -15.66 -0.53 5.03e-47 Aortic root size; BRCA cis rs9868809 0.772 rs34096717 chr3:48719453 A/C cg00383909 chr3:49044727 WDR6 0.57 9.81 0.36 2.85e-21 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs35110281 0.840 rs7276633 chr21:45078800 C/T cg04455712 chr21:45112962 RRP1B 0.4 10.67 0.39 1.45e-24 Mean corpuscular volume; BRCA cis rs2637030 0.559 rs2607501 chr5:52989545 A/T cg06476337 chr5:52856530 NDUFS4 0.37 8.41 0.32 2.76e-16 Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction);Waist circumference adjusted for BMI in active individuals;Waist circumference adjusted for body mass index; BRCA cis rs6840258 0.825 rs72667751 chr4:87936379 C/T cg08197287 chr4:87952173 AFF1 -0.42 -8.34 -0.31 4.6e-16 Mean corpuscular volume;Basophil percentage of granulocytes; BRCA cis rs6951245 1.000 rs74785791 chr7:1088494 T/C cg23708337 chr7:1209742 NA 0.64 8.93 0.33 4.47e-18 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs1005277 0.579 rs1780145 chr10:38537070 A/G cg18963800 chr10:38644991 HSD17B7P2 -0.41 -8.04 -0.3 4.24e-15 Extrinsic epigenetic age acceleration; BRCA cis rs13191362 1.000 rs13201023 chr6:162981381 C/G cg06582575 chr6:163149167 PACRG;PARK2 0.81 12.03 0.43 3.33e-30 Body mass index;BMI in non-smokers;Body mass index (joint analysis main effects and physical activity interaction);BMI (adjusted for smoking behaviour);Body mass index in physically active individuals;Body mass index (joint analysis main effects and smoking interaction); BRCA trans rs7200543 1.000 rs1121 chr16:15131076 G/A cg24683922 chr1:11983373 KIAA2013 -0.39 -8.72 -0.33 2.45e-17 Glycerophospholipid levels;Metabolic traits;Body mass index;Triglyceride levels; BRCA trans rs7618501 0.815 rs3819325 chr3:49843723 T/C cg21659725 chr3:3221576 CRBN 0.7 20.96 0.64 1.24e-74 Intelligence (multi-trait analysis); BRCA cis rs67311347 0.911 rs6776044 chr3:40377503 T/G cg09455208 chr3:40491958 NA 0.4 9.58 0.35 2.14e-20 Renal cell carcinoma; BRCA cis rs6752107 1.000 rs6738490 chr2:234161583 T/C cg07618928 chr2:234183455 ATG16L1;SCARNA5 0.51 11.5 0.41 5.88e-28 Crohn's disease;Inflammatory bowel disease; BRCA trans rs208515 0.556 rs12201658 chr6:66678457 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.77 14.54 0.5 1.32e-41 Exhaled nitric oxide levels; BRCA cis rs2280018 0.526 rs2966128 chr16:15153389 G/T cg27102117 chr16:15229624 NA 0.41 9.68 0.36 9.29e-21 Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid);Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs2795502 1.000 rs2795496 chr10:43337842 G/A cg20628663 chr10:43360327 NA -0.69 -13.51 -0.47 9.07e-37 Blood protein levels; BRCA cis rs2658782 0.901 rs11604909 chr11:93218355 C/G cg15737290 chr11:93063684 CCDC67 0.49 9.17 0.34 6.55e-19 Pulmonary function decline; BRCA cis rs10197940 0.662 rs1047957 chr2:152333773 C/T cg19508488 chr2:152266495 RIF1 0.43 9.39 0.35 1.01e-19 Lung cancer; BRCA cis rs6815814 0.950 rs5743566 chr4:38805942 G/C cg06935464 chr4:38784597 TLR10 0.51 8.49 0.32 1.46e-16 Breast cancer; BRCA cis rs13136331 0.680 rs2732208 chr4:88650530 C/T cg12990093 chr4:88570587 DMP1 -0.39 -7.84 -0.3 1.84e-14 Sitting height ratio; BRCA cis rs910316 1.000 rs13099 chr14:75599155 G/A cg23033748 chr14:75592666 NEK9 -0.42 -10.28 -0.38 4.63e-23 Height; BRCA cis rs7811142 0.775 rs1636980 chr7:99938864 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 -1.02 -17.54 -0.57 1.66e-56 Platelet count; BRCA cis rs798502 0.541 rs2644307 chr7:2832973 G/A cg19717773 chr7:2847554 GNA12 -0.46 -9.66 -0.36 1.04e-20 Waist circumference adjusted for BMI (adjusted for smoking behaviour);Inflammatory bowel disease;Waist circumference adjusted for BMI in non-smokers;Ulcerative colitis;Waist circumference adjusted for body mass index;Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction); BRCA cis rs9814567 0.896 rs13089566 chr3:134349710 G/C cg06109529 chr3:134205091 CEP63;ANAPC13 0.55 17.83 0.58 4.99e-58 Neurocognitive impairment in HIV-1 infection (dichotomous); BRCA trans rs3733585 0.604 rs73215003 chr4:10126317 C/G cg26043149 chr18:55253948 FECH -0.39 -8.29 -0.31 6.5e-16 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs72781680 1.000 rs11553491 chr2:24225901 G/C cg08917208 chr2:24149416 ATAD2B 0.9 12.92 0.46 4.27e-34 Lymphocyte counts; BRCA cis rs561341 1.000 rs550923 chr17:30327013 G/C cg00745463 chr17:30367425 LRRC37B -0.54 -8.88 -0.33 6.88e-18 Hip circumference adjusted for BMI; BRCA cis rs10752881 1.000 rs6701400 chr1:182977197 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.87 0.56 4.51e-53 Colorectal cancer; BRCA cis rs2842992 0.673 rs6930904 chr6:160217433 T/A cg19482086 chr6:160211437 TCP1;MRPL18 0.7 18.03 0.58 4.67e-59 Age-related macular degeneration (geographic atrophy); BRCA trans rs6582630 0.593 rs7299329 chr12:38447943 G/C cg06521331 chr12:34319734 NA -0.46 -8.56 -0.32 8.29e-17 Drug-induced liver injury (flucloxacillin); BRCA cis rs2204008 0.837 rs4312131 chr12:38181087 G/T cg26384229 chr12:38710491 ALG10B 0.76 17.18 0.56 1.18e-54 Bladder cancer; BRCA cis rs4853012 0.838 rs60705299 chr2:74345370 C/G cg20891558 chr2:74357851 NA 0.53 12.68 0.45 5.17e-33 Gestational age at birth (maternal effect); BRCA cis rs6088580 0.634 rs1205338 chr20:32925625 C/G cg24642439 chr20:33292090 TP53INP2 -0.54 -11.65 -0.42 1.42e-28 Glomerular filtration rate (creatinine); BRCA cis rs1568889 1.000 rs35697240 chr11:28287342 G/C cg06544937 chr11:28130018 METT5D1;KIF18A 0.62 13.04 0.46 1.24e-34 Bipolar disorder; BRCA cis rs7568458 0.684 rs3731828 chr2:85806266 C/T cg02493740 chr2:85810744 VAMP5 -0.56 -11.36 -0.41 2.28e-27 Coronary artery disease;Coronary artery disease (myocardial infartum, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease); BRCA cis rs9921222 0.521 rs11649255 chr16:357140 A/G cg12437481 chr16:420112 MRPL28 -0.4 -8.73 -0.33 2.19e-17 Bone mineral density (spine);Bone mineral density; BRCA cis rs4975616 0.869 rs466502 chr5:1325767 C/T cg07493874 chr5:1342172 CLPTM1L 0.51 14.61 0.5 6.06e-42 Lung cancer; BRCA cis rs12887734 0.566 rs8548 chr14:104199580 A/C cg26031613 chr14:104095156 KLC1 -0.54 -9.08 -0.34 1.3e-18 Schizophrenia;Autism spectrum disorder or schizophrenia; BRCA cis rs10504229 0.953 rs67886764 chr8:58187117 T/C cg22535103 chr8:58192502 C8orf71 -0.62 -13.45 -0.47 1.72e-36 Developmental language disorder (linguistic errors); BRCA cis rs875971 0.638 rs3898855 chr7:66036398 G/C cg11764359 chr7:65958608 NA -0.68 -15.38 -0.52 1.14e-45 Aortic root size; BRCA cis rs72781680 0.752 rs72796119 chr2:23917179 C/T cg20701182 chr2:24300061 SF3B14 0.63 8.91 0.33 5.3e-18 Lymphocyte counts; BRCA cis rs9467711 0.591 rs13201821 chr6:26057781 A/C cg08501292 chr6:25962987 TRIM38 0.59 8.28 0.31 6.98e-16 Autism spectrum disorder or schizophrenia; BRCA cis rs4664304 0.620 rs2729705 chr2:160710922 T/C cg14819504 chr2:160761413 LY75 -0.34 -8.3 -0.31 6.24e-16 Crohn's disease;Inflammatory bowel disease; BRCA cis rs7945705 0.875 rs2653616 chr11:8885892 A/G cg12365402 chr11:9010492 NRIP3 -0.36 -8.35 -0.31 4.3e-16 Hemoglobin concentration; BRCA cis rs9467773 0.649 rs2145318 chr6:26496603 T/A cg11502198 chr6:26597334 ABT1 0.44 8.22 0.31 1.1e-15 Intelligence (multi-trait analysis); BRCA cis rs7408868 0.831 rs7245850 chr19:15274585 A/C cg14696996 chr19:15285081 NOTCH3 0.99 14.37 0.49 8.85e-41 Pulse pressure; BRCA trans rs6582630 0.555 rs1969362 chr12:38514843 C/T cg06521331 chr12:34319734 NA -0.46 -8.5 -0.32 1.33e-16 Drug-induced liver injury (flucloxacillin); BRCA cis rs61931739 0.534 rs10844729 chr12:34022919 A/G cg06521331 chr12:34319734 NA -0.61 -11.07 -0.4 3.68e-26 Morning vs. evening chronotype; BRCA cis rs4363385 0.818 rs546666 chr1:153015385 A/G cg25856811 chr1:152973957 SPRR3 -0.32 -8.46 -0.32 1.88e-16 Inflammatory skin disease; BRCA cis rs7826238 0.720 rs12546760 chr8:8374836 A/G cg08975724 chr8:8085496 FLJ10661 -0.42 -9.18 -0.34 5.94e-19 Systolic blood pressure; BRCA cis rs8028182 0.636 rs8036758 chr15:75817562 G/A cg20655648 chr15:75932815 IMP3 0.42 8.03 0.3 4.78e-15 Sudden cardiac arrest; BRCA cis rs17818399 0.926 rs7590693 chr2:46823992 G/A cg02822958 chr2:46747628 ATP6V1E2 0.48 9.23 0.34 3.77e-19 Height; BRCA cis rs10504229 0.683 rs61364624 chr8:58134339 T/A cg24829409 chr8:58192753 C8orf71 -0.46 -8.86 -0.33 7.63e-18 Developmental language disorder (linguistic errors); BRCA cis rs9837602 0.529 rs793495 chr3:99507934 A/G cg06077670 chr3:99629837 C3orf26;FILIP1L;MIR548G 0.67 15.11 0.51 2.58e-44 Breast cancer; BRCA cis rs7586879 0.639 rs6749170 chr2:25110962 A/G cg01884057 chr2:25150051 NA 0.34 8.85 0.33 8.67e-18 Body mass index; BRCA cis rs7520050 0.931 rs6698247 chr1:46371486 C/T cg24296786 chr1:45957014 TESK2 0.43 9.85 0.36 2.18e-21 Red blood cell count;Reticulocyte count; BRCA cis rs7582180 0.663 rs4850930 chr2:100990955 T/C cg14675211 chr2:100938903 LONRF2 0.43 9.58 0.35 2.06e-20 Intelligence (multi-trait analysis); BRCA cis rs7811142 0.943 rs28578163 chr7:100044754 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.1 24.5 0.7 5.31e-94 Platelet count; BRCA cis rs2294693 0.945 rs9349175 chr6:40982401 T/C cg14769373 chr6:40998127 UNC5CL -0.38 -7.86 -0.3 1.68e-14 Gastric cancer;Non-cardia gastric cancer; BRCA cis rs919433 0.963 rs4850429 chr2:198178409 A/G cg10820045 chr2:198174542 NA 0.4 8.41 0.32 2.71e-16 Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy); BRCA cis rs10899021 0.920 rs76121309 chr11:74343921 A/T cg25880958 chr11:74394337 NA -0.65 -8.45 -0.32 1.99e-16 Response to metformin (IC50); BRCA cis rs17270561 0.609 rs2000350 chr6:25763154 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 9.66 0.36 1.1e-20 Iron status biomarkers; BRCA cis rs2629540 0.889 rs4962696 chr10:126445630 A/G cg08799069 chr10:126477246 METTL10 -0.54 -11.69 -0.42 9.55e-29 Cocaine dependence; BRCA cis rs10779751 0.726 rs1205593 chr1:11252716 T/C cg08854313 chr1:11322531 MTOR 0.72 14.05 0.49 2.8e-39 Body mass index; BRCA cis rs7829975 0.593 rs2979241 chr8:8303353 G/C cg15556689 chr8:8085844 FLJ10661 0.51 14.44 0.5 3.93e-41 Mood instability; BRCA trans rs629535 0.773 rs681534 chr8:70056964 A/C cg21567404 chr3:27674614 NA 1.0 21.33 0.64 1.25e-76 Dupuytren's disease; BRCA cis rs7520050 0.933 rs4504835 chr1:46455571 G/A cg24296786 chr1:45957014 TESK2 0.44 9.81 0.36 2.95e-21 Red blood cell count;Reticulocyte count; BRCA cis rs6570726 0.791 rs9403734 chr6:145931459 C/G cg23711669 chr6:146136114 FBXO30 0.78 18.56 0.59 7.74e-62 Lobe attachment (rater-scored or self-reported); BRCA cis rs1707322 0.752 rs6703748 chr1:46095976 G/A cg03146154 chr1:46216737 IPP 0.52 11.73 0.42 6.24e-29 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs7589728 0.858 rs79992736 chr2:88530575 A/C cg24977027 chr2:88469347 THNSL2 0.43 8.04 0.3 4.34e-15 Plasma clusterin levels; BRCA cis rs9462027 0.628 rs9462023 chr6:34769410 T/G cg07306190 chr6:34760872 UHRF1BP1 -0.26 -7.83 -0.3 1.98e-14 Systemic lupus erythematosus; BRCA cis rs752010 1.000 rs752010 chr1:42093015 C/T cg06885757 chr1:42089581 HIVEP3 0.27 9.65 0.36 1.12e-20 Lupus nephritis in systemic lupus erythematosus; BRCA cis rs2197308 0.728 rs7304305 chr12:37932990 T/C cg13010199 chr12:38710504 ALG10B -0.41 -8.75 -0.33 1.94e-17 Morning vs. evening chronotype; BRCA cis rs2404602 0.716 rs117129193 chr15:76656803 A/G cg23625390 chr15:77176239 SCAPER 0.38 9.14 0.34 8.08e-19 Blood metabolite levels; BRCA cis rs4713118 0.824 rs2179095 chr6:27750858 A/G cg08798685 chr6:27730294 NA 0.42 8.1 0.31 2.82e-15 Parkinson's disease; BRCA cis rs758324 0.704 rs40401 chr5:131396478 C/T cg06307176 chr5:131281290 NA -0.41 -8.64 -0.32 4.59e-17 Alzheimer's disease in APOE e4- carriers; BRCA cis rs875971 0.545 rs35459055 chr7:65944386 G/A cg11764359 chr7:65958608 NA 0.64 11.47 0.41 7.88e-28 Aortic root size; BRCA cis rs2115630 0.691 rs2292462 chr15:85200754 G/T cg12501888 chr15:85177176 SCAND2 -0.37 -9.31 -0.35 1.95e-19 P wave terminal force; BRCA cis rs6582630 0.538 rs12305104 chr12:38336353 C/T cg26384229 chr12:38710491 ALG10B -0.42 -9.45 -0.35 6.24e-20 Drug-induced liver injury (flucloxacillin); BRCA cis rs72781680 0.821 rs72796401 chr2:24180078 T/A cg08917208 chr2:24149416 ATAD2B 0.62 10.44 0.38 1.18e-23 Lymphocyte counts; BRCA cis rs6701037 0.566 rs729675 chr1:175136946 T/C cg00321850 chr1:175162397 KIAA0040 0.43 12.31 0.44 2.06e-31 Alcohol dependence; BRCA cis rs6545883 0.894 rs778158 chr2:61555421 A/G cg15711740 chr2:61764176 XPO1 0.52 13.15 0.46 3.91e-35 Tuberculosis; BRCA cis rs769267 0.965 rs2965188 chr19:19522557 G/A cg17414380 chr19:19431394 KIAA0892;SF4 0.44 9.09 0.34 1.28e-18 Tonsillectomy; BRCA cis rs3733585 0.605 rs4235355 chr4:10123078 C/A cg00071950 chr4:10020882 SLC2A9 -0.51 -11.68 -0.42 1.01e-28 Cleft plate (environmental tobacco smoke interaction); BRCA cis rs6952808 0.500 rs3778996 chr7:2177190 G/A cg00106254 chr7:1943704 MAD1L1 -0.38 -8.85 -0.33 8.52e-18 Bipolar disorder and schizophrenia; BRCA cis rs9818758 0.607 rs67831908 chr3:49313513 T/G cg00383909 chr3:49044727 WDR6 0.74 12.31 0.44 2.06e-31 High light scatter reticulocyte percentage of red cells;Reticulocyte fraction of red cells;Reticulocyte count;Glycated hemoglobin levels; BRCA cis rs7246657 0.653 rs4805207 chr19:37673733 G/A cg18154014 chr19:37997991 ZNF793 0.55 9.25 0.34 3.46e-19 Coronary artery calcification; BRCA cis rs7727544 1.000 rs10076701 chr5:131596419 A/G cg12564285 chr5:131593104 PDLIM4 0.34 9.1 0.34 1.17e-18 Blood metabolite levels; BRCA cis rs10899021 1.000 rs10899025 chr11:74367040 G/A cg25880958 chr11:74394337 NA -0.51 -8.0 -0.3 5.96e-15 Response to metformin (IC50); BRCA cis rs35110281 0.626 rs162367 chr21:44934857 A/G cg21573476 chr21:45109991 RRP1B -0.32 -8.19 -0.31 1.44e-15 Mean corpuscular volume; BRCA trans rs801193 1.000 rs3778909 chr7:66255646 G/C cg05627663 chr7:65219948 SNORA22;CCT6P1 0.38 8.26 0.31 8.36e-16 Aortic root size; BRCA trans rs208520 0.690 rs207107 chr6:66794385 T/C cg15611600 chr13:45563400 KIAA1704;NUFIP1 -1.01 -21.23 -0.64 4.44e-76 Exhaled nitric oxide output; BRCA cis rs12477438 0.798 rs6716913 chr2:99580641 T/C cg14399236 chr2:99771627 LIPT1;TSGA10 -0.67 -14.72 -0.5 1.95e-42 Chronic sinus infection; BRCA cis rs514406 0.584 rs7548832 chr1:53193576 A/T cg16325326 chr1:53192061 ZYG11B 0.86 23.92 0.69 8.86e-91 Monocyte count; BRCA cis rs67478160 0.619 rs11160761 chr14:104254856 A/T cg08213375 chr14:104286397 PPP1R13B 0.64 18.28 0.59 2.23e-60 Schizophrenia; BRCA cis rs4466137 0.553 rs16898 chr5:82986149 T/C cg15083037 chr5:83017644 HAPLN1 -0.38 -8.56 -0.32 8.13e-17 Prostate cancer; BRCA cis rs10464366 0.746 rs62442210 chr7:39146328 G/T cg20302533 chr7:39170763 POU6F2 0.38 7.87 0.3 1.54e-14 IgG glycosylation; BRCA cis rs7772486 0.875 rs2814863 chr6:146347299 C/T cg23711669 chr6:146136114 FBXO30 -0.7 -16.23 -0.54 7.19e-50 Lobe attachment (rater-scored or self-reported); BRCA cis rs769267 0.930 rs4808964 chr19:19603692 A/C cg17414380 chr19:19431394 KIAA0892;SF4 -0.44 -8.97 -0.33 3.16e-18 Tonsillectomy; BRCA cis rs7246967 0.551 rs3925175 chr19:22880958 G/A cg23217946 chr19:22817039 ZNF492 0.48 8.93 0.33 4.47e-18 Bronchopulmonary dysplasia; BRCA cis rs1401999 1.000 rs2176824 chr3:183654029 C/G cg01324343 chr3:183735012 ABCC5 0.85 21.76 0.65 5.82e-79 Anterior chamber depth; BRCA cis rs757081 0.667 rs12577525 chr11:17260116 G/A cg15432903 chr11:17409602 KCNJ11 -0.46 -8.68 -0.32 3.25e-17 Systolic blood pressure; BRCA cis rs7811142 0.775 rs1059129 chr7:99926522 A/G cg21679810 chr7:100027352 MEPCE;ZCWPW1 0.9 16.19 0.54 1.13e-49 Platelet count; BRCA cis rs12971120 1.000 rs3829640 chr18:72174980 A/G cg14963724 chr18:72166303 CNDP2 -0.34 -7.89 -0.3 1.29e-14 Refractive error; BRCA trans rs11098499 0.754 rs1980025 chr4:120252806 A/G cg25214090 chr10:38739885 LOC399744 -0.43 -9.9 -0.36 1.39e-21 Corneal astigmatism; BRCA cis rs7091068 0.550 rs7079013 chr10:95487878 A/C cg20715218 chr10:95462985 C10orf4 0.53 10.91 0.4 1.58e-25 Urinary tract infection frequency; BRCA trans rs11098499 0.644 rs6855918 chr4:120546299 C/T cg25214090 chr10:38739885 LOC399744 0.45 10.11 0.37 2.1e-22 Corneal astigmatism; BRCA cis rs1509123 0.609 rs7224971 chr17:6713999 A/T cg12642237 chr17:6703447 TEKT1 0.85 11.1 0.4 2.77e-26 Blood metabolite levels; BRCA cis rs13118159 0.801 rs10024996 chr4:1328297 G/A cg19318889 chr4:1322082 MAEA 0.34 7.91 0.3 1.12e-14 Longevity; BRCA cis rs7312933 0.558 rs11181467 chr12:42765250 C/T cg01256987 chr12:42539512 GXYLT1 -0.43 -8.28 -0.31 7.25e-16 Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid); BRCA cis rs10504229 0.728 rs72650855 chr8:58152570 A/G cg20607798 chr8:58055168 NA 0.53 8.4 0.32 2.85e-16 Developmental language disorder (linguistic errors); BRCA cis rs34779708 0.966 rs34296409 chr10:35404613 C/G cg03585969 chr10:35415529 CREM 0.56 11.5 0.41 5.77e-28 Inflammatory bowel disease;Crohn's disease; BRCA cis rs12973672 1.000 rs8101606 chr19:35774556 A/C cg12095397 chr19:35769544 USF2 0.38 8.4 0.32 2.81e-16 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA trans rs61931739 0.500 rs3924704 chr12:34557833 C/T cg26384229 chr12:38710491 ALG10B 0.73 15.99 0.53 1.2e-48 Morning vs. evening chronotype; BRCA cis rs1707322 0.752 rs28550303 chr1:46188914 G/T cg06784218 chr1:46089804 CCDC17 0.5 12.03 0.43 3.45e-30 Body mass index in physically active individuals;Body mass index;Body mass index (joint analysis main effects and physical activity interaction); BRCA cis rs2404602 0.583 rs2456076 chr15:76557553 T/G cg26408565 chr15:76604113 ETFA 0.5 11.5 0.41 5.9e-28 Blood metabolite levels; BRCA cis rs6951245 1.000 rs11770909 chr7:1086716 G/A cg21664854 chr7:1097933 C7orf50;GPR146 0.6 11.35 0.41 2.62e-27 C-reactive protein levels or total cholesterol levels (pleiotropy); BRCA cis rs4242434 0.672 rs10099266 chr8:22484268 C/G cg03733263 chr8:22462867 KIAA1967 0.75 16.75 0.55 1.8e-52 Exploratory eye movement dysfunction in schizophrenia (cognitive search score); BRCA cis rs4319547 1.000 rs6489157 chr12:123101673 C/G cg05707623 chr12:122985044 ZCCHC8 0.46 9.57 0.35 2.25e-20 Body mass index; BRCA cis rs2014572 0.967 rs10413671 chr19:57763489 G/A cg24459738 chr19:57751996 ZNF805 -0.36 -8.55 -0.32 8.76e-17 Hyperactive-impulsive symptoms; BRCA cis rs7584330 0.697 rs9287620 chr2:238368730 C/T cg11271282 chr2:238384023 NA 0.47 8.81 0.33 1.15e-17 Prostate cancer; BRCA cis rs7927771 0.524 rs7107922 chr11:47669289 C/A cg20307385 chr11:47447363 PSMC3 0.42 9.69 0.36 8.54e-21 Subjective well-being; BRCA cis rs3806843 0.966 rs12659129 chr5:140147248 T/C cg16179182 chr5:140090404 VTRNA1-1 -0.41 -9.51 -0.35 3.8e-20 Depressive symptoms (multi-trait analysis); BRCA cis rs9372253 0.678 rs9487392 chr6:110708626 C/T cg01119278 chr6:110721349 DDO 0.42 9.92 0.37 1.13e-21 Platelet distribution width; BRCA cis rs1420338 0.967 rs9655014 chr7:34148632 T/C cg01275685 chr7:34179230 BMPER -0.47 -10.26 -0.38 5.71e-23 Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer; BRCA cis rs4319547 0.956 rs10744275 chr12:123048618 A/G cg23029597 chr12:123009494 RSRC2 -0.63 -12.7 -0.45 4.06e-33 Body mass index; BRCA cis rs637571 0.726 rs689274 chr11:65665988 A/G cg04055107 chr11:65626734 MUS81;CFL1 -0.43 -9.22 -0.34 4.13e-19 Eosinophil percentage of white cells; BRCA cis rs6450176 1.000 rs5024170 chr5:53300827 C/A ch.5.1024479R chr5:53302184 ARL15 -0.62 -15.07 -0.51 3.83e-44 HDL cholesterol levels;HDL cholesterol;Adiponectin levels; BRCA cis rs9790314 0.791 rs6809256 chr3:161026513 G/A cg04691961 chr3:161091175 C3orf57 -0.42 -10.31 -0.38 3.63e-23 Morning vs. evening chronotype; BRCA cis rs3820068 0.524 rs34094056 chr1:15824154 G/T cg17385448 chr1:15911702 AGMAT 0.37 7.81 0.3 2.35e-14 Systolic blood pressure; BRCA cis rs7707921 0.801 rs862243 chr5:81586829 C/G cg15871215 chr5:81402204 ATG10 0.35 8.29 0.31 6.7e-16 Breast cancer; BRCA cis rs1552244 0.882 rs34706481 chr3:10004123 G/A cg00149659 chr3:10157352 C3orf10 0.67 10.24 0.38 6.96e-23 Alzheimer's disease; BRCA cis rs736408 0.522 rs11716747 chr3:52748857 C/T cg10712668 chr3:52740153 GLT8D1;SPCS1 0.49 11.18 0.4 1.22e-26 Bipolar disorder; BRCA cis rs9868809 1.000 rs2310997 chr3:48678011 G/C cg00383909 chr3:49044727 WDR6 0.55 8.1 0.31 2.8e-15 Ulcerative colitis;Crohn's disease;Inflammatory bowel disease; BRCA cis rs765787 0.530 rs4775836 chr15:45537664 T/C cg25801113 chr15:45476975 SHF 0.31 8.05 0.3 4.16e-15 Uric acid levels; BRCA cis rs6952808 0.601 rs3778978 chr7:2159817 A/G cg03354898 chr7:1950403 MAD1L1 -0.45 -9.02 -0.34 2.17e-18 Bipolar disorder and schizophrenia; BRCA trans rs3780486 0.846 rs913214 chr9:33135085 G/A cg20290983 chr6:43655470 MRPS18A 1.11 40.6 0.85 4.27e-179 IgG glycosylation; BRCA cis rs10751667 0.643 rs11246362 chr11:969818 C/T ch.11.42038R chr11:967971 AP2A2 0.52 16.51 0.55 2.86e-51 Alzheimer's disease (late onset); BRCA cis rs2204008 0.837 rs7315255 chr12:37949279 G/A cg13010199 chr12:38710504 ALG10B 0.5 9.93 0.37 1.07e-21 Bladder cancer; BRCA cis rs17270561 0.609 rs2154218 chr6:25776290 T/C cg16482183 chr6:26056742 HIST1H1C 0.49 9.7 0.36 7.4e-21 Iron status biomarkers; BRCA cis rs758324 0.947 rs9327622 chr5:131125080 T/A cg06307176 chr5:131281290 NA 0.53 10.26 0.38 5.85e-23 Alzheimer's disease in APOE e4- carriers; BRCA cis rs6460942 0.915 rs62448602 chr7:12457145 T/G cg20607287 chr7:12443886 VWDE -0.58 -8.32 -0.31 5.34e-16 Coronary artery disease; BRCA cis rs769267 0.965 rs2074550 chr19:19387743 A/C cg11584989 chr19:19387371 SF4 0.31 8.0 0.3 5.7e-15 Tonsillectomy; BRCA cis rs826838 0.967 rs1352122 chr12:39130885 G/A cg13010199 chr12:38710504 ALG10B -0.44 -10.28 -0.38 4.77e-23 Heart rate; BRCA cis rs6089829 0.925 rs6122086 chr20:61664528 T/C cg03213289 chr20:61660250 NA 0.63 16.52 0.55 2.52e-51 Prostate cancer (SNP x SNP interaction); BRCA trans rs61931739 0.500 rs6488213 chr12:34393319 C/T cg13010199 chr12:38710504 ALG10B 0.43 9.08 0.34 1.35e-18 Morning vs. evening chronotype; BRCA cis rs10911232 0.507 rs10911212 chr1:183024469 C/T ch.1.3577855R chr1:183094577 LAMC1 0.64 16.64 0.55 6.67e-52 Hypertriglyceridemia; BRCA cis rs4319547 0.626 rs10744210 chr12:122931793 A/G cg05707623 chr12:122985044 ZCCHC8 -0.5 -9.71 -0.36 7.18e-21 Body mass index; BRCA cis rs2115630 1.000 rs1030863 chr15:85282635 C/T cg12863693 chr15:85201151 NMB -0.34 -8.14 -0.31 2.12e-15 P wave terminal force; BRCA cis rs2439831 0.850 rs28891769 chr15:44072860 C/G cg10011062 chr15:43941034 CATSPER2 -0.53 -7.81 -0.3 2.27e-14 Lung cancer in ever smokers; BRCA cis rs7811142 1.000 rs67239991 chr7:100046504 A/G cg13153964 chr7:100026424 MEPCE;ZCWPW1 1.11 25.08 0.7 3.78e-97 Platelet count; BRCA cis rs9291683 0.588 rs2240722 chr4:10020757 A/G cg02734326 chr4:10020555 SLC2A9 0.41 8.83 0.33 9.65e-18 Bone mineral density; BRCA cis rs9399135 0.636 rs4646871 chr6:135265617 A/G cg22676075 chr6:135203613 NA -0.38 -7.85 -0.3 1.71e-14 Red blood cell count; BRCA cis rs7582180 0.607 rs1530029 chr2:100968205 C/T cg08017756 chr2:100939284 LONRF2 -0.31 -7.96 -0.3 8.17e-15 Intelligence (multi-trait analysis); BRCA cis rs13256369 0.950 rs13248096 chr8:8577476 C/T cg17143192 chr8:8559678 CLDN23 0.52 10.08 0.37 2.88e-22 Obesity-related traits; BRCA cis rs4930103 0.590 rs3809101 chr11:1967271 C/T cg23202291 chr11:1979235 NA 0.37 7.92 0.3 1.03e-14 DNA methylation (parent-of-origin);DNA methylation (variation); BRCA cis rs6878727 0.562 rs2633528 chr5:123641078 G/A cg01806427 chr5:123737813 NA -0.36 -8.0 -0.3 5.94e-15 Breast cancer; BRCA cis rs6912958 0.781 rs6454631 chr6:88225863 G/A cg08069147 chr6:88032118 GJB7;C6orf162 -0.44 -8.63 -0.32 4.8e-17 Monocyte percentage of white cells; BRCA cis rs4631830 0.720 rs11004422 chr10:51498336 A/G cg16070123 chr10:51489643 NA 0.35 7.85 0.3 1.73e-14 Prostate-specific antigen levels; BRCA trans rs208520 1.000 rs9453671 chr6:66991208 A/G cg15611600 chr13:45563400 KIAA1704;NUFIP1 0.72 12.43 0.44 6.65e-32 Exhaled nitric oxide output; BRCA cis rs7786877 0.723 rs73407376 chr7:100215200 C/T cg20848291 chr7:100343083 ZAN -0.6 -11.41 -0.41 1.48e-27 Mean corpuscular hemoglobin;Mean corpuscular volume; BRCA cis rs2625529 0.652 rs2957750 chr15:72332258 C/T cg16672083 chr15:72433130 SENP8 0.67 16.06 0.54 5.26e-49 Red blood cell count; BRCA cis rs4319547 0.956 rs10847179 chr12:123040985 T/C cg23029597 chr12:123009494 RSRC2 -0.65 -13.04 -0.46 1.3e-34 Body mass index; BRCA cis rs67478160 0.643 rs34813623 chr14:104263294 A/G cg26031613 chr14:104095156 KLC1 -0.42 -8.45 -0.32 1.94e-16 Schizophrenia; BRCA cis rs10924970 0.625 rs10925482 chr1:235499263 C/T cg26050004 chr1:235667680 B3GALNT2 0.36 8.45 0.32 1.99e-16 Asthma; BRCA cis rs2762353 0.595 rs12207313 chr6:25741027 G/C cg03264133 chr6:25882463 NA 0.72 16.88 0.56 4e-53 Blood metabolite levels; BRCA cis rs35146811 0.735 rs11764176 chr7:99786964 G/T cg13334819 chr7:99746414 C7orf59 -0.34 -8.11 -0.31 2.68e-15 Coronary artery disease; BRCA cis rs9311474 0.629 rs7636227 chr3:52566682 G/A cg11041457 chr3:52719354 GNL3;PBRM1 0.26 8.64 0.32 4.65e-17 Electroencephalogram traits; BRCA cis rs34172651 0.917 rs6497760 chr16:24806535 G/A cg00152838 chr16:24741724 TNRC6A -0.36 -7.98 -0.3 6.88e-15 Intelligence (multi-trait analysis); BRCA cis rs875971 0.862 rs1167390 chr7:65575893 G/A cg05627663 chr7:65219948 SNORA22;CCT6P1 -0.37 -7.95 -0.3 8.63e-15 Aortic root size; BRCA cis rs2070488 0.699 rs13064938 chr3:38440237 T/C cg24069376 chr3:38537580 EXOG 0.3 8.38 0.31 3.39e-16 Electrocardiographic conduction measures; BRCA trans rs7618501 0.573 rs2624824 chr3:50088266 T/C cg21659725 chr3:3221576 CRBN -0.47 -12.16 -0.43 9.18e-31 Intelligence (multi-trait analysis); BRCA cis rs8114671 0.839 rs2104084 chr20:33649217 G/C cg07148914 chr20:33460835 GGT7 -0.42 -9.1 -0.34 1.16e-18 Height; BRCA cis rs2991971 0.934 rs2991974 chr1:46020654 A/G cg15605315 chr1:45957053 TESK2 0.46 9.45 0.35 6.53e-20 High light scatter reticulocyte count; BRCA cis rs701145 0.585 rs12493885 chr3:153839866 G/C cg12800244 chr3:153838788 SGEF 0.63 7.9 0.3 1.22e-14 Coronary artery disease; BRCA cis rs873946 0.648 rs12769533 chr10:134548685 C/T cg13271783 chr10:134563150 INPP5A 0.46 9.37 0.35 1.19e-19 Gestational age at birth in labor-initiated deliveries (child effect);Gestational age at birth (child effect); BRCA cis rs8177253 0.829 rs6794945 chr3:133518463 A/G cg11941060 chr3:133502564 NA 0.59 13.93 0.48 9.86e-39 Iron status biomarkers; BRCA cis rs12210905 0.688 rs72841376 chr6:27456321 G/A cg08851530 chr6:28072375 NA 0.81 8.01 0.3 5.42e-15 Hip circumference adjusted for BMI; BRCA cis rs4862750 0.914 rs9998558 chr4:187874691 A/G cg11301795 chr4:187892539 NA -0.31 -10.15 -0.37 1.55e-22 Lobe attachment (rater-scored or self-reported); BRCA trans rs9329221 0.772 rs7824675 chr8:10243418 G/T cg06636001 chr8:8085503 FLJ10661 -0.46 -9.98 -0.37 6.84e-22 Neuroticism; BRCA cis rs9649213 0.593 rs6465662 chr7:97917801 A/T cg21770322 chr7:97807741 LMTK2 0.42 11.3 0.41 4e-27 Prostate cancer (SNP x SNP interaction); BRCA trans rs9951602 0.512 rs12607938 chr18:76651887 A/C cg02800362 chr5:177631904 HNRNPAB 0.77 18.38 0.59 6.87e-61 Obesity-related traits; BRCA cis rs7582180 0.585 rs12999151 chr2:100939333 G/A cg14675211 chr2:100938903 LONRF2 0.52 11.96 0.43 7.15e-30 Intelligence (multi-trait analysis); BRCA cis rs10504229 0.683 rs77548248 chr8:58117542 G/A cg20607798 chr8:58055168 NA 0.47 8.25 0.31 9.1e-16 Developmental language disorder (linguistic errors);